gebhart/patrepeval huggingface dataset:
Suppression Of Ages Formation In Spontaneous Diabetic OLETF Rat By Organic Germanium Compound [Poly-trans-(2-carboxyethyl) Germasesquioxane] (Ge-132) (1999)

The model rat for the type 2 diabetes mellitus (NIDDM) in human were observed for 72 weeks after birth, administering an organic germanium compound [Bis(2-Carboxyethyl) germasesquioxane, Ge-132] perorally 100 mg/kg/day since 24 weeks old. Clinical examinations were followed throughout the observation period. Blood and urinary glucose in positive control OLETF rats tended to be higher than those treated with Ge-132. At the end of the 72nd week, animals were sacriificed to examine the pathological changes, specifically in pancreas, kidney and brain. Anti-AGE antibody stained proximal and distal tubles and basement membrane of glomerules in kidney, and accumulated AGE masses in cortex, hippocampus and cerebellum of OLETF rat's brain. Amyloid stains by basic congo red on kidney and brain revealed that the deposits of amyloid in kidney mesangium and in cortex, hippocampus and cerebellum were observable in OLETF rats. Ge-132 suppressed the deposition of amyloid tangles in kidneys and brains. Anti rat complement C'3 antibody reacted with AGE and amyloid tangles that were sensitive to anti-AGE antibody. AGE generated in vitro by incubating human serum, human gammaglobulin (HGG), or bovine serum albumin (BSA) with glucose activated complements, showing the consumption of complements in the hemolysis of hemolysin-coated sheep red blood cells. A novel device Quantum Resonance Spectrometer (QRS) could read the subtle bio-magnetism memorized in serum samples, demonstrating quantitative values reflecting the patho-physiology of OLETF rats.
False Target Detection in OFDM-based Joint RADAR-Communication Systems (2023)

Joint RADAR communication (JRC) systems that use orthogonal frequency division multiplexing (OFDM) can be compromised by an adversary that re-produces the received OFDM signal creating thus false RADAR targets. This paper presents a set of algorithms that can be deployed at the JRC system and can detect the presence of false targets. The presence of a false target is detected depending on whether there is residual carrier frequency offset (CFO) beyond Doppler in the received signal, with a Generalized Likelihood Ratio Test (GLRT). To evaluate the performance of our approach we measure the detection probability versus the false alarm rate through simulation for different system configurations of an IEEE 802.11-based JRC system.
Prevalence of chronic chikungunya and associated risks factors in the French West Indies (La Martinique). A prospective cohort study (2019)

Abstract Background The chikungunya virus (CHIKV) is a re-emerging alphavirus that can cause chronic rheumatic musculoskeletal disorders, named chronic chikungunya (CHIKC+), which may be long-term incapacitating. A chikungunya outbreak occurred in 2013 in La Martinique. We constituted the first prospective cohort study of CHIKV-infected subjects in the Caribbean to assess the prevalence of CHIKC+ at 12 months and to search for factors present at the acute stage significantly associated with chronicity. Methodology/Principal findings A total of 193 patients who tested positive for RT-PCR CHIKV, were submitted to clinical investigations in the acute phase (&lt;21 days), and 3, 6, and 12 months after their inclusion. A total of 167 participants could be classified as either suffering or not from CHIKC+. They were analyzed using logistic regression models. At 12 months, the overall prevalence of CHIKC+ was 52.1% (95%CI: 44.5-59.7). In univariate analysis, age (OR: 1.04; 95% CI: 1.02-1.07; p=0.0003), being male (OR: 0.51; 95%CI: 0.27-0.98; p=0.04), headache (OR: 1.90; 95%CI: 1.02-3.56; p=0.04), vertigo (OR: 2.06; 95%CI: 1.05-4.03; p=0.04), vomiting (OR: 2.51; 95%CI: 1.07-5.87; p = 0.03), urea (OR: 1.33; 95%CI: 1.05-1.70; p=0.02) were associated with CHIKC+. In final multivariate logistic regression models for 167 participants, predictors of CHIKC+ were age (OR 1.06; 95%CI: 1.03-1.08; p&lt;0.0001), male sex (OR: 0.40; 95%CI: 0.19-0.84; p=0.015), vertigo (OR: 2.46; 95%CI: 1.16-5.20; p=0.019), hypotension (OR 4.72; 95% -CI: 1.19-18.79; p=0.028), recoloration time &gt;3 seconds (OR: 3.79; 95%-CI: 1.01-14.25). Conclusions This cohort study in La Martinique confirms that CHIKC+ is a frequent complication of acute chikungunya disease. Analysis emphasized the importance of age and female sex for CHIKC occurrence, and pointed out the potential aggravating role of dehydration at the acute phase. Early and adequate hydration could reduce the risk chronic chikungunya disorders. Author Summary Chikungunya is a mosquito-borne virus found in tropical countries that has been re-emerging in the last decade. It has caused major epidemics in recent years, such as in Reunion Island and in Southeast Asia. Nearly 2.5 billion people around the world are at risk of contracting the virus. During the acute phase of the illness, patients experience a flu-like syndrome with fever, headache, myalgia, rash, and severe arthralgia. These symptoms can persist for several months in some patients, and can lead to significant functional disability. During the 2013 epidemic in Martinique, we followed nearly 200 patients who had contracted chikungunya. More than half of the patients had a chronic form of the disease—mainly women over 50 years of age. Our statistical analyses indicate that poor hydration during the acute phase may be a risk factor for developing chronic rheumatism. Therefore, in the context of a chikungunya epidemic, it seems important to encourage patients to drink plenty of fluids as soon as the first symptoms appear.
Testing against Natural Language Requirements (2007)

Testing against natural language requirements is the standard approach for system and acceptance testing. This test is often performed by an independent test organization unfamiliar with the application area. The only things the testers have to go by are the written requirements. So it is essential to be able to analyze those requirements and to extract test cases from them. In this paper an automated approach to requirements based testing is presented and illustrated on an industrial application.
Relative transfer function identification on manifolds for supervised GSC beamformers (2013)

Identification of a relative transfer function (RTF) between two microphones is an important component of multichannel hands-free communication systems in reverberant and noisy environments. In this paper, we present an RTF identification method on manifolds for supervised generalized sidelobe canceler beamformers. We propose to learn the manifold of typical RTFs in a specific room using a novel extendable kernel method, which relies on common manifold learning approaches. Then, we exploit the extendable learned model and propose a supervised identification method that relies on both the a priori learned geometric structure and the measured signals. Experimental results show significant improvements over a competing method that relies merely on the measurements, especially in noisy conditions.
Enhanced Alternate Action Recommender System Using Recurrent Patterns and Fault Detection System for Smart Home Users (2019)

We present a fault tolerant alternate action recommender system for smart home Internet of Things (IoT) users to enrich the user experience with uninterrupted routines and various methods to achieve the regular routines in the smart home system. Our system takes events data from the smart home IoT devices as input, performs preprocessing using the big data handling techniques to transform it to be applicable to our system, applies our custom pattern-mining algorithm to derive the highly probable and active recurrent patterns of an individual user, ensures those frequently used devices are up and running using our fault detection monitoring system, and then finally recommends the alternate possibilities of achieving the deviated actions. Our custom fault detection system is based on various parameters of the IoT devices and context of the smart home users wherein the alternate recommendations given to the user are practical and useful in real time. We validated our system using user trial methods and various validation techniques.
Progenitor clonal común en leucemia linfática crónicay leucemia linfoblástica aguda en el mismo paciente (2004)

crisis blastica en LMC, hecho referido en recientes publicaciones. Cabria sin embargo cuestionar si esta crisis blastica corresponderia realmente a una segunda crisis blastica. Este mecanismo se apoyaria en el hecho de que el perfil inmunologico de la clona medular era superponible. Una explicacion justificativa de este comportamiento radicaria en que el imatinib mesilato alcanza concentraciones en LCR muy inferiores a las plasmaticas y esta concentracion seria insuficiente para erradicar posibles focos extramedulares de enfermedad minima residual (EMR), aun cuando pueda tener cierto efecto retardador. Por todo ello, queremos hacer patente la necesidad de abordar de forma integrada el enfoque terapeutico de posibles focos de EMR extramedular, ya que las nuevas opciones terapeuticas, aun siendo efectivas en el control de las recaidas medulares, no lo son tanto sobre localizaciones como las que presentaba nuestro paciente.
Validation of a methodology for neuro-urological and lumbosacral stimulation studies in domestic pigs: a humanlike animal model (2019)

Pigs represent an ideal model for SCS studies aimed at visceral function investigation and restoration because of the close similarities between female domestic pigs and humans, both in terms of anatomical structure and experimental techniques implemented. This article provides methodological keys for conducting experiments with equipment routinely used in clinical practice.
Glucose Intolerance After Short-term Administration of Corticosteroids in Healthy Subjects (1989)

Glucocorticoid-induced glucose intolerance has been related to the dose, duration of treatment, and steroid compound. However, a clear demonstration of this phenomenon is still lacking for fluorinated corticosteroids. We performed an oral glucose tolerance test in six healthy volunteers after the short-term administration of deflazacort (18 + 18 mg), prednisone (15 + 15 mg), and betamethasone disodium phosphate (1.5 + 1.5 mg) at equivalent anti-inflammatory doses, in random sequence, and in a triple crossover design. Fasting plasma glucose levels were not modified by deflazacort, whereas fasting plasma glucose levels together with insulin and C-peptide values were progressively and significantly increased by prednisone and betamethasone. During oral glucose tolerance testing a significant increase in the plasma glucose and insulin peaks was recorded after betamethasone and, to a lesser extent, after prednisone and deflazacort. These results suggest that betamethasone induces greater glucose intolerance and insulin resistance than prednisone and deflazacort.
Not Just Skipping. Understanding the Effect of Sponsored Content on Users' Decision-Making in Online Health Search (2022)

Advertisements (ads) are an innate part of search engine business models. Advertisers are willing to pay search engines to promote their content to a prominent position in the search result page (SERP). This raises concerns about the search engine manipulation effect (SEME): the opinions of users can be influenced by the way search results are presented. In this work, we investigate the connection between SEME and sponsored content in the health domain. We conduct a series of user studies in which participants need to evaluate the effectiveness of different non-prescription natural remedies for various medical conditions. We present participants SERPs with different intentionally created biases towards certain viewpoints, with or without sponsored content, and ask them to evaluate the effectiveness of the treatment only based on the information presented to them. We investigate two types of sponsored content: 1. Direct marketing ads that directly market the product without expressing an opinion about its effectiveness, and 2. Indirect marketing ads that explicitly advocate the product's effectiveness on the condition in the query. Our results reveal a significant difference between the influence on users from these two ad types. Though direct marketing ads are mostly skipped by users, they can tilt users decision making towards more positive viewpoints. Indirect marketing ads affect both the users' examination behaviour and their perception of the treatment's effectiveness. We further discover that the contrast between the indirect marketing ads and the viewpoint presented in the organic search results plays an important role in users' decision-making. When the contrast is high, users exhibit a strong preference towards a negative viewpoint, and when the contrast is low or none, users exhibit preference towards a more positive viewpoint.
A brittle to ductile transition in ice under tension (1984)

Abstract Experiments have revealed a brittle to less-brittle transition in polycrystalline ice Ih slowly strained (10−6 s1) under uniaxial tension at temperatures from −20°C to −5°C. The transition occurs at a ‘critical grain size’ (≃ 1–5 mm) where the stress to nucleate cracks equals the stress to propagate them. The tensile strength of more coarsely-grained aggregates is controlled by crack nucleation and obeys an expression of the Hall-Fetch type; viz. [sgrave]TN − [sgrave]'i+k'd−½, when [sgrave]′i and k′ are experimentally determined materials parameters and d is grain size. The strength of more finely-grained material appears to be controlled by crack propagation and is given by an expression of the form [sgrave]Tp = Kd−½ where K is another materials parameter.
Notch Signaling Induces Multilineage Myeloid Differentiation and Up-Regulates PU.1 Expression (2003)

Hemopoietic commitment is initiated by and depends on activation of transcription factors. However, it is unclear whether activation of lineage-affiliated transcription factors is extrinsically regulated by to date unknown agents or is the result of a cell autonomous program. Here we show that signaling by the Notch1 transmembrane receptor instructively induces myeloid differentiation of multipotent hemopoietic progenitor cells and concomitantly up-regulates the expression of the transcription factor PU.1. Transient activation of Notch1 signaling is sufficient to irreversibly reduce self-renewal of multipotent progenitor cells accompanied by increased and accelerated differentiation along the granulocyte, macrophage, and dendritic cell lineages. Activated Notch1 has no direct influence on apoptosis of multipotent progenitor cells, shows a weak inhibition of proliferation, and does not substitute for survival and proliferation signals provided by cytokines. Activated Notch1 directly increases PU.1 RNA levels, leading to a high concentration of PU.1 protein, which has been shown to direct myeloid differentiation. These findings identify Notch as an extrinsic regulator of myeloid commitment, and the lineage-affiliated transcription factor PU.1 as a specific direct target gene of Notch.
Cardiac transplantation in Puerto Rican patients at the Texas Heart Institute. (1991)

Cardiac transplantation is the treatment of choice for patients suffering from end-stage cardiac disease unamenable to conventional medical or surgical treatment. More than 390 patients have undergone heart transplantation at the Texas Heart Institute in Houston, and nine were Puerto Rican. Overall survival of these patients is 88%. Our experience with patients from Puerto Rico is described.
Systematic mining of fungal chimeric terpene synthases using an efficient precursor-providing yeast chassis (2021)

Chimeric terpene synthases, which consist of C-terminal prenyltransferase (PT) and N-terminal class I terpene synthase (TS) domains (termed PTTSs here), is unique to fungi and produces structurally diverse di- and sesterterpenes. Prior to this study, 20 PTTSs had been functionally characterized. Our understanding of the origin and functional evolution of <i>PTTS</i> genes is limited. Our systematic search of sequenced fungal genomes among diverse taxa revealed that <i>PTTS</i> genes were restricted to Dikarya. Phylogenetic findings indicated different potential models of the origin and evolution of <i>PTTS</i> genes. One was that <i>PTTS</i> genes originated in the common Dikarya ancestor and then underwent frequent gene loss among various subsequent lineages. To understand their functional evolution, we selected 74 <i>PTTS</i> genes for biochemical characterization in an efficient precursor-providing yeast system employing chassis-based, robot-assisted, high-throughput automatic assembly. We found 34 <i>PTTS</i> genes that encoded active enzymes and collectively produced 24 di- and sesterterpenes. About half of these di- and sesterterpenes were also the products of the 20 known PTTSs, indicating functional conservation, whereas the PTTS products included the previously unknown sesterterpenes, sesterevisene (1), and sesterorbiculene (2), suggesting that a diversity of PTTS products awaits discovery. Separating functional PTTSs into two monophyletic groups implied that an early gene duplication event occurred during the evolution of the PTTS family followed by functional divergence with the characteristics of distinct cyclization mechanisms.
Disposition of Heroin and Its Metabolites in Heroin-Related Deaths (1994)

Although many deaths occur annually from heroin intoxication, the presence of heroin has not been reported in postmortem tissues. Recognizing heroin's susceptibility to rapid chemical and metabolic hydrolysis, extraction procedures were developed for the efficient recovery of heroin, 6-acetylmorphine, and morphine from postmortem tissue utilizing solid-phase extraction coupled with gas chromatography/mass spectrometry. From heroin-related deaths, 21 sets of blood and urine specimens were collected. The mode of death in these cases was categorized as rapid, delayed, or undetermined. Compared with delayed deaths, rapid deaths were characterized by the following trends: higher mean concentrations of 6-acetylmorphine, free morphine, and total opiates in blood; a higher ratio of free morphine concentrations to total opiate concentrations in blood; lower mean concentrations of 6-acetylmorphine and morphine in urine; greater likelihood of 6-acetylmorphine detection in blood; and lesser likelihood of heroin detection in urine. The study also included analysis of multiple tissue specimens from two subjects who died of heroin intoxication. Heroin was identified in urine and injection-site tissue. Concentrations of 6-acetylmorphine in cerebrospinal fluid, spleen, and brain were substantially higher than in blood, liver, lung, and kidney. All specimens were positive for morphine. Heroin metabolites were detected in hair specimens. The identification of heroin and 6-acetylmorphine in biological tissues effectively established the presence of heroin in cases of acute narcotic intoxication. These studies demonstrated that measurement of heroin and its metabolites provides useful information for the differential diagnosis of heroin-related deaths.
New Ultra-Short Wideband Amplifying Erbium Doped Fiber (2002)

Key properties of our new class of heavy metal containing silicate glass based erbium doped fiber EDF for optical amplifier are reported, discussing its very attractive combination of ultra compact fiber length (up to 100 times shorter than conventional EDF with Giles gain g*=210 dB/m) and efficient wideband and flat amplification obtaining up to 50% more bandwidth than conventional silica based EDF
Kinetic Study of Human β- 1,4-Galactosyltrasgerase Expressed in E.coli1 (1993)

Recombinant beta-1,4-galactosyltransferase which synthesizes the Gal beta 1-->4GlcNAc group of glycoprotein sugar chains was obtained as a soluble form from Escherichia coli by transfection of the human cDNA lacking the transmembrane segment. Kinetic study revealed that the soluble transferase has the same apparent Km values toward sugar nucleotide and sugar acceptors as those of mouse membrane-bound beta-1,4-galactosyltransferase previously characterized [Nakazawa et al. (1991) Eur. J. Biochem. 196, 363-368]. However, the Vmax value of this transferase was low when compared to that of the mammalian transferase, probably due to the instability of the transferase caused by the lack of protein glycosylation. The soluble transferase was purified from the E. coli lysates almost to homogeneity by chromatography on DEAE-Sepharose and alpha-lactalbumin-Sepharose columns. Using this purified transferase, the acceptor specificity of the transferase has been studied. The results showed that the transferase has apparent Km values of 170, 190, and 830 microM for agalacto-poly-N-acetyllactosamine, lacto-N-triose II, and lacto-N-triaosylceramide, respectively, but has apparently no activity toward glucosylceramide. These results suggest that the beta-1,4-galactosyltransferase may be involved in the synthesis of poly-N-acetyllactosamine, lacto-N-neotetraose, and probably lacto-N-neotetraosylceramide in addition to the formation of the Gal beta 1-->4GlcNAc group of glycoprotein sugar chains and lactose.
Operating system support for high-performance, real-time CORBA (2002)

A broad range of applications (such as avionics, telecommunication systems, and multimedia on demand) require various types of real-time guarantees from the underlying middleware, operating systems, and networks to achieve their quality of service (QoS). In addition to providing real-time guarantees and end-to-end QoS, the underlying services used by these applications must be reliable, flexible, and reusable. Requirements for reliability, flexibility and reusability motivate the use of object-oriented middleware like the Common Object Request Broker Architecture (CORBA). However the performance of current CORBA implementations is not suitable for latency-sensitive real-time applications, including both hard real-time systems (e.g., avionics), and constrained latency systems (e.g., teleconferencing). This paper describes key changes that must be made to the CORBA specifications, existing CORBA implementations, and the underlying operating system to develop real-time ORBs (RT ORBs). RT ORBs must deliver real-time guarantees and end-to-end QoS to latency-sensitive applications. While many operating systems now support real-time scheduling, they do not provide integrated solutions. The main thesis of this paper is that advances in real-time distributed object computing can be achieved only by simultaneously integrating techniques and tools that simplify application development; optimize application, I/O subsystem, and network performance; and systematically measure performance to pinpoint and alleviate bottlenecks.
How to Present a Paper (1992)

This three-page note is about presenting a paper at a conference, but it offers good advice for any talk. Except for a couple of suggestions about hand-written slides, it still applies today.
Hybrid Structure based On-line Learning Method for Robust Pose Prediction (2017)

객체 인식 기술은 컴퓨터 비전 기반 어플리케이션에서 다양하게 사용된다. 본 논문은 급격히 변화하는 환경에서 객체 인식을 위한 실시간 특징점 기반 추적 기법과 포즈 예측 방법에 대해 제안하고자 한다. 실시간 객체 추적을 위한 연구는 이전부터 많이 진행되어 왔지만, 급격한 영상 변화 등 복잡한 환경에서는 아직 개선해야 할 부분들이 존재한다. 이에, 본 논문은 특징점 필터링, 하이브리드 구조 기반의 온라인 학습의 2단계로 구성하여 연구를 진행하였다. 특징점 필터링 단계는 강인한 추적을 위해 특징점 매칭 이전에 수행되는 단계로, 추출된 특징점의 공간적 분포와 질을 고려하여 특징점을 추출한다. 하이브리드 구조기반의 온라인 학습 단계에서는 강인한 포즈인식을 위해 Structured support vector machine (SSVM) 기반 러닝 기법을 적용하였다. 제안하는 시스템의 성능 검증을 위해, 공용 DB 와 자체제작 DB를 포함한 총 13개의 비디오를 사용하여 다양한 검출기-서술자 기반의 성능검증 실험을 진행하고, 최신 연구와의 비교실험을 통해 만족할만한 성능을 확인하였다.