gebhart/patrepeval huggingface dataset:
A comparative study of the cytotoxic activities of three plants: Curcuma zedoaria, pinus maritima and curcuma xanthorrhiza on skin cancer A375 and HSC-5 cell lines (2018)

Background-Nowadays much attention has been focus on the use of natural plant-derived therapies. The three kinds of Thai plants, Curcuma zedoaria (CZ), Pinus maritima (PM) and Curcuma xanthorrrhiza (CX) have been reported to have many biological and physiological properties and potential to be used as a medicine in many clinical heaths but its anti-cancer effect is still less well understood. Objective-To evaluate and compare the signaling cytotoxicity pathways of three kinds of Thai plants-CZ, PM, and CX through intracellular reactive oxygen species (ROS) in different dose on the skin cancer cell line A375 and HSC-5. Methods-We evaluated the cytotoxic activities of three plants-CZ, PM, and CX on human melanoma A375 cell line and squamous cell carcinoma HSC-5 cell line after their supplementation by detection of intracellular ROS using CM-H2DCFDA as the fluorescent probe. Results-We found that only PM significantly induced oxidative stress responses in term of ROS generation on both A375 cells and HSC-5 cell therefore, it was the most potentially cytotoxic effect within dose dependent. Conclusion - Bark extract from Pinus maritima has potentially cytotoxic and oxidative damage against both skin cancer cells by inducing ROS-mediated autosis.
Planar degenerated anchoring of liquid crystals obtained by surface memory passivation (2000)

Weak anchoring of liquid crystals on solid substrates is usually dominated by the surface memory. We show that the memory can be removed by surface passivation by silane molecules. We realize planar, azimuthally degenerated, and memory-free anchorings without pretilt.
Abstract 15490: The Association Between Measurements of Body Composition and the Prevalence of Hypertension, Diabetes and Dyslipidemia in Patients Without Coronary Artery Disease (2022)

Background: The body Mass Index (BMI) is commonly used in clinical practice to screen for obesity and resulting cardiometabolic conditions. Nonetheless, BMI has limited utility as it cannot differentiate body fat (BF). Hypothesis: We tested the hypothesis that BF content measured by air displacement plethysmography (Bod-Pod®) had a stronger association with prevalent hypertension (HTN), diabetes mellitus (DM) and dyslipidemia (DLP) when compared to BMI. Methods: We performed a community-based cross-sectional study on adults attending an employee wellness center from January 2007-December 2011 who had had a body composition assessment with Bod-Pod®. We excluded subjects with history of myocardial infarction, coronary artery disease, congestive heart failure, stroke at baseline. The prevalence of HTN, DM and DLP was assessed across quartiles of BF% and BMI categories. Their association with BF% and BMI was evaluated using linear regression models that adjusted for age, sex, and white race. Results: We included 3,052 individuals; 68 % were women, and the mean age ± SD was 42.09±12.8, BMI was 27.9±6.2; BF% 31.88±10.69, 892 (29.2%) were obese by BMI. Cardiometabolic conditions were prevalent in 496 (16.2%) with HTN, 378 (12.4%) with DM and 743 (24.4%) with DLP. While the prevalence of DM, HTN and DLP increased across BF% quartiles (all p for linearity&gt;0.01), this was not always the case across BMI categories (p for linearity&lt;0.05 for HTN and DLP, and 0.04 for DM) see Figure A . Elevated BF %, better identified individuals with HTN (AUC 0.766 vs 0.625; p&lt;0.001), DM (AUC 0.643 vs. 0.568; p&lt;0.001), DLP (AUC 0.758 vs. 0.593; p&lt;0.001). Conclusion: BF content is better associated with a higher prevalence of HTN, DM, and DLP. Highlighting the role of body composition assessment in primary prevention. Dyslipidemia.
Measurement of enhanced vasa vasorum density in a porcine carotid model using photon counting detector CT (2023)

Whole-body PCD-CT scanners can be used to detect and quantify the increased perfusion occurring within the porcine carotid arterial wall resulting from an increased density of vasa vasorum.
PARS PLANA IMPLANT AND VITRECTOMY FOR TREATMENT OF NEOVASCULAR GLAUCOMA (1995)

Purpose: To evaluate the effectiveness of pars plana implants in the treatment of neovascular glaucoma. Patients and Methods: Twenty-two consecutive pars plana implant procedures performed for neovascular glaucoma were retrospectively reviewed. Results: Preoperative intraocular pressures ranged from 22 to 80 mmHg (mean 46 mmHg) on a mean of three glaucoma medications. With a mean follow-up interval of 16 months, final postoperative intraocular pressures ranged 9-21 mmHg (mean 16) on a mean 0.7 medications. One patient required a second implant to achieve final intraocular pressure control. Visual acuity was stabilized or improved in 19 of 22 cases (86%). Complications included retinal detachment in two cases (9%). Macular pucker, vitreous hemorrhage, hyphema, choroidal hemorrhage, diplopia, and loss of light perception occurred in one case (5%) each. None developed phthisis bulbi. Conclusion: Pars plana drainage tube implants are effective in the treatment of neovascular glaucoma.
ChemInform Abstract: An Abnormal Barton‐Zard Reaction Leading to the Pyrrolo(2,3‐b)indole Ring System. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Anesthesia for foreign bodies in the tracheo-bronchial tree in children. (1985)

The authors present the anesthetic and ventilation techniques, used in 106 children, who were suspected of foreign body aspiration in the respiratory tract. In 62 children a foreign body was found. The youngest child was 8 months old and the oldest 13 years, with an age distribution peak in the 1 to 2 years age group. A predominance for the male sex (60%) was present. Foreign bodies of organic nature were found most frequently (80%), 39 of them consisting of peanuts. The bronchi were involved more often than the trachea and the foreign body was located more frequently at the right bronchus (38 pt). The children were ventilated initially with an intermittent oxygen jet injection technique, using a home made apparatus, but since 1978 with HFPPV, using the AGA Bronchovent. Induction of anesthesia was done with halothane and maintenance with etomidate infusion (10-20 micrograms/kg/min.) or thiopental increments (2 to 3 mg/kg). The technique so far used, proved to be satisfactory, specially since HFPPV is used. Few complications occurred. One child died during the bronchoscopic procedure and in an other child a tracheostomy had to be performed for extraction of the foreign body.
Vliv tělesného tréninku na systolickou funkci levé komory unemocných s ICHS (2006)

Pouze u nemocných s pravidelnou 12 měsicni fyzickou aerobni
aktivitou doslo ke zlepseni celkove i regionalni systolicke
funkce LK.
An efficient euler number computing algorithm (2015)

The Euler number of a binary image is a very important topological property for image processing pattern recognition, and computer vision. This paper proposes an efficient run-based algorithm for Euler number computing. For calculating 8-neighbor runs, unlike the conventional run-based algorithm, which needs to record start points and end points of all runs, our algorithm only needs to record end points of runs in odd rows. By our method, the number of pixel accesses required for computing Euler number will decrease. Experimental results on various noise images demonstrated that our algorithm outperforms conventional Euler number computing algorithms.
Prolactin and Glucocorticoid Hormones Control Transcription of the β-Casein Gene by Kinetically Distinct Mechanisms (1990)

Transcription of the beta-casein milk protein gene in the HC11 mouse mammary epithelial cell line is induced synergistically by the hormones glucocorticoid and PRL. Sequential treatment of HC11 cells with glucocorticoid and PRL demonstrated that the two hormones had different modes of action on beta-casein transcription. Pretreatment with dexamethasone enhanced the response to subsequent induction by PRL, but not vice versa. Dexamethasone increased the sensitivity of the cells to respond to PRL. The increase in sensitivity was slow, extended for 16 days, and could be rapidly reversed by withdrawal of dexamethasone. The dexamethasone-induced sensitivity for the rapid transcriptional regulation by PRL could be observed with transfected rat beta-casein promoter-chloramphenicol acetyltransferase constructs retaining only 175 basepairs upstream from the transcription initiation site. Expression of the endogenous mouse beta-casein gene was regulated identically to that of the promoter constructs with respect to the synergy of the hormones and their different kinetics of action. In contrast to the slow induction of sensitivity toward PRL, dexamethasone rapidly induced the transcription of a mouse mammary tumor virus long terminal repeat controlled gene in HC11. This demonstrated a normal transcriptional activation of the glucocorticoid receptor in this cell line. Thus, glucocorticoid may regulate beta-casein gene transcription indirectly, inducing or repressing other glucocorticoid-regulated genes, whereas the interaction of PRL with its receptor causes a rapid induction of the beta-casein gene promoter.
ChemInform Abstract: Topotactic Transformation of the Cationic Conductor Li4Mo5O17 into a Rock Salt Type Oxide Li12Mo5O17. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Frequency Tuning Technique of Piezoelectric Ultrasonic Transducers for Ranging Applications (2018)

This paper presents a novel low-cost technique for the frequency tuning of piezoelectric micromachined ultrasonic transducers (PMUT). PMUT devices are fabricated using the PiezoMUMPs technology with resonance frequencies of the first and second modes at 1.4 MHz and 5 MHz, respectively. The influence of process variations on resonance frequency (with a standard deviation of about 200 kHz) motivates the need for a simple and low cost frequency tuning method. This paper proposes a technique based on a single post-processing deposition of Parylene-C. Chip-to-chip transmission and distance ranging results show that the resonant frequency of the first and second modes can accurately be tuned over a satisfactory range to significantly increase ultrasonic transmission performance. The application cases for the proposed method focus on single transducer devices or small arrays thereof since Parylene deposition simultaneously occurs on all elements of a chip and results in a uniform frequency tuning of all exposed elements.
Arsenic and Lung Disease Mortality in Bangladeshi Adults (2014)

This prospective investigation of lung disease mortality, using individual-level arsenic measures and skin lesion status, confirms a deleterious effect of ingested arsenic on mortality from lung disease. Further investigations should evaluate effects on the incidence of specific lung diseases, more fully characterize dose-response, and evaluate screening and biomedical interventions to prevent premature death among arsenic-exposed populations, particularly among those who may be most susceptible to arsenic toxicity.
Cover Picture: Inhibitors of HIV‐1 Integrase‐Human LEDGF/p75 Interaction Identified from Natural Products via Virtual Screening (Chin. J. Chem. 12/2012) (2012)

The cover picture shows the discovery of inhibitors targeting HIV-1 integrase-human LEDGF/p75 interaction via virtual screening. One of the most challenges for anti-HIV therapy is the rapid emergence of drug resistance. Protein-protein interaction inhibitors bring us hopes to overcome the viral resistance. We conducted a virtual screening combined with bioassays to search such inhibitors from natural product library. Several compounds were discovered to block integrase- LEDGF/p75 interaction with potent activities. These findings could be helpful for anti-HIV drug discovery. More details are discussed in the article by Tang et al. on page 2752–2758.
Development of a Seismic Design Approach for Infill Walls Equipped with Structural Fuse (2012)

Presented herein is a seismic design approach developed for a proposed infill wall “structural fuse” system for use in building frames. The purpose of this system is to prevent damage to frame or infill walls due to infill wall-frame in-teraction during potentially damaging earthquakes by isolating them through a “sacrificial” component or a structural fuse. The design approach includes a procedure for design and application of the fuse system in a multi-bay, multi-story build-ing with moment resisting frames. The empirical equation developed to predict the in-plane strength of masonry infill walls equipped with structural fuse is discussed. A calculation method is suggested to specify an appropriate fuse element capacity arrangement in a building frame in order to achieve desirable and controlled structural performance. The design procedure is shown through application to two buildings used for example, a low-rise (4-story) and a mid-rise (8-story) building. The result of the study demonstrates that the proposed isolation system has merits and can potentially improve the seismic performance of masonry infill walls by protecting the infill wall and the frame from damages due to their in-teraction.
Concentration of Transforming Growth Factor β<sub>2</sub> in Aqueous Humor (2005)

The total transforming growth factor (TGF) beta(2) concentration in the anterior chamber aqueous humor of 96 cataract patients with ages ranging from 17 to 88 years was measured using ELISA to investigate the changes that occur with age, difference of axial length, difference of localization of opacification of the cataractous lens and complications with other eye diseases. It was found that the total TGF-beta(2) concentration (1) decreases with age, (2) shows slight changes with axial length, (3) has slight changes with difference of localization of opacification, (4) is significantly high in patients with concurrent open-angle glaucoma (p < 0.05), (5) is high in patients with complicating diabetes who have undergone panretinal photocoagulation for diabetic retinopathy (p < 0.05) and (6) is low in patients with atopic cataracts. There have been several reports on point 4 above, but none to date of the other points. These findings provide useful information on the intraocular activity of TGF-beta(2).
A pulse-periodic torch in a coaxial waveguide: Formation dynamics and spatial structure (2004)

Results are presented from experimental studies of the formation dynamics, spatial structure, and parameters of a pulse-periodic microwave discharge excited in a coaxial waveguide. The experimental setup allows the stable generation of a plasma jet in molecular and atomic gas flows at pressures close to atmospheric pressure without applying additional initiators. The complicated sequence of processes leading to torch formation cannot be adequately described with conventional models of a discharge sustained by a surface electromagnetic wave.
Fluorescence Flutter Shutter for Imaging Cells in Flow (2013)

We demonstrate a method for imaging fluorescently labeled cells traveling at high linear velocities. Images are collected with an engineered motion-blur which enables exposures that are 50 times longer than the motion-blur limit.
Unveiling turbo codes: some results on parallel concatenated coding schemes (1996)

A parallel concatenated coding scheme consists of two simple constituent systematic encoders linked by an interleaver. The input bits to the first encoder are scrambled by the interleaver before entering the second encoder. The codeword of the parallel concatenated code consists of the input bits to the first encoder followed by the parity check bits of both encoders. This construction can be generalized to any number of constituent codes. Parallel concatenated schemes employing two convolutional codes as constituent codes, in connection with an iterative decoding algorithm of complexity comparable to that of the constituent codes, have been previously shown to yield remarkable coding gains close to theoretical limits. They have been named, and are known as, "turbo codes". We propose a method to evaluate an upper bound to the bit error probability of a parallel concatenated coding scheme averaged over all interleavers of a given length. The analytical bounding technique is then used to shed some light on some crucial questions, which have been floating around in the communications community since the proposal of turbo codes.
Discovery of a novel route to β-thymidine: a precursor for anti-AIDS compounds (1994)

A. V. R. Rao, M. K. Gurjar and S. V. S. Lalitha, J. Chem. Soc., Chem. Commun., 1994, 1255 DOI: 10.1039/C39940001255
Commitment to the Osteoblast Lineage Is Not Required for RANKL Gene Expression (2009)

Differentiation of bone-resorbing osteoclasts from hematopoietic precursors depends upon expression of the cytokine receptor activator of NFkappaB ligand (RANKL) by fibroblastic stromal cells, which some evidence suggests are of the osteoblast lineage. We have shown previously that hormonal-responsiveness of the murine RANKL gene is mediated in part by a distal enhancer that binds Runx2, a transcription factor required for commitment to the osteoblast lineage, supporting the idea that osteoclast-supporting stromal cells may be osteoblasts or their progenitors. However, in this study we demonstrate that parathyroid hormone (PTH) stimulation of RANKL in mice is not affected by a significant reduction in the number of osteoblasts. Consistent with this, neither Runx2, nor Cbfb, a binding partner essential for Runx activity, are required for basal or PTH-stimulated RANKL expression in fibroblastic stromal cell models. Nonetheless, RANKL responsiveness to PTH was elevated in cultured calvaria cells expressing high levels of osterix, another transcription factor required for osteoblast differentiation, and this was associated with elevated PTH receptor expression. The responsiveness of RANKL to 1,25-dihydroxyvitamin D(3) was not elevated in the osterix-expressing cells. Together, these results suggest that commitment to the osteoblast lineage is not a requirement for RANKL gene transcription in fibroblastic stromal cells but may enhance responsiveness of this gene to specific hormones via control of their receptors.
Improving the Security of UML Sequence Diagram Using Genetic Algorithm (2020)

A sequence diagram is a modeling approach for visualizing the behavioral execution of a system. The objective of this research is to investigate the problem of security in a behavioral model (sequence diagram) through the application of model refactoring. We propose detection and correction techniques, empirical evaluation of the proposed techniques and assessment of security improvement in sequence diagrams. The detection of security bad smells is achieved through the adaptation of a genetic algorithm, while correction is accomplished by the model transformation approach. The results show significant detection recall and correction efficacy of the proposed detection and correction approaches, respectively. Our results show that the proposed approach is effective in detecting and correcting bad smells and can improve the security of UML Sequence Diagram.
Dissecting the Structural Organization of Multiprotein Amyloid Aggregates Using a Bottom-Up Approach (2020)

Deposition of fibrillar amyloid β (Aβ) in senile plaques is a pathological signature of Alzheimer's disease. However, senile plaques also contain many other components, including a range of different proteins. Although the composition of the plaques can be analyzed in post-mortem tissue, knowledge of the molecular details of these multiprotein inclusions and their assembly processes is limited, which impedes the progress in deciphering the biochemical mechanisms associated with Aβ pathology. We describe here a bottom-up approach to monitor how proteins from human cerebrospinal fluid associate with Aβ amyloid fibrils to form plaque particles. The method combines flow cytometry and mass spectrometry proteomics and allowed us to identify and quantify 128 components of the captured multiprotein aggregates. The results provide insights into the functional characteristics of the sequestered proteins and reveal distinct interactome responses for the two investigated Aβ variants, Aβ(1-40) and Aβ(1-42). Furthermore, the quantitative data is used to build models of the structural organization of the multiprotein aggregates, which suggests that Aβ is not the primary binding target for all the proteins; secondary interactions account for the majority of the assembled components. The study elucidates how different proteins are recruited into senile plaques and establishes a new model system for exploring the pathological mechanisms of Alzheimer's disease from a molecular perspective.
Angiotensin-Converting Enzyme Inhibition Does Not Suppress Plasma Angiotensin II Increase During Exercise in Humans (1993)

Physical effort stimulates the reninangiotensin system (RAS). We studied the effect of an angiotensin-converting enzyme inhibitor (ACE inhibitor) in a double-blind placebo-controlled study, on eight volunteers undergoing physical stress on an ergometric bicycle. The effects of captopril (C) (50 mg, three times daily for 3 days) on arterial pressure (AP), O2 consumption (VO2), variations in auricular natriuretic factor (ANF), renin, angiotensin II (AII) plasma levels, as well as glomerular filtration rate (GFR) and microalbuminuria (MA) were evaluated. The different parameters were compared by analysis of variance (ANOVA). The pressure profile and VO2 were not modified by ACE inhibitor. Exercise stimulates release of renin; this action was greater with captopril administration (treatment effect: p < 10(-4), indicating blockade of the RAS. This inhibition was incomplete because AII levels increased markedly when captopril was given (no treatment effect: p < 0.37). Finally, ACE inhibitor resulted in decreased GFR (p = 115 +/- 5.8 ml/mn-1, C = 91.1 +/- 4, p < 0.05) with exercise without modification of MA. ACE inhibitor administration does not modify the physical performance of nonathletic subjects; AII is significantly increased with exercise despite captopril treatment; ACE inhibitor decreases GFR significantly but does not influence MA with prolonged physical effort.
Who Switches from Medigap to Medicare HMOs? (2002)

We examined selection bias in joining managed care plans among the subset of Medicare beneficiaries who have Medigap policies. No strong evidence of selection bias was found in this population. We conclude that there was no evidence that the Medigap market is becoming prohibitively expensive as a result of unfavorable selection.