gebhart/patrepeval huggingface dataset:
An assessment of the relative contributions of redox and steric issues to laccase specificity towards putative substrates (2008)

Laccases catalyze the one-electron oxidation of a broad range of substrates coupled to the 4 electron reduction of O2 to H2O. Phenols are typical substrates, because their redox potentials (ranging from 0.5 to 1.0 V vs. NHE) are low enough to allow electron abstraction by the T1 Cu(II) that, although a relatively modest oxidant (in the 0.4-0.8 V range), is the electron-acceptor in laccases. The present study comparatively investigated the oxidation performances of Trametes villosa and Myceliophthora thermophila laccases, two enzymes markedly differing in redox potential (0.79 and 0.46 V). The oxidation efficiency and kinetic constants of laccase-catalyzed conversion of putative substrates were determined. Hammett plots related to the oxidation of substituted phenols by the two laccases, in combination with the kinetic isotope effect determination, confirmed a rate-determining electron transfer from the substrate to the enzyme. The efficiency of oxidation was found to increase with the decrease in redox potential of the substrates, and the Marcus reorganisation energy for electron transfer to the T1 copper site was determined. Steric hindrance to substrate docking was inferred because some of the phenols and anilines investigated, despite possessing a redox potential compatible with one-electron abstraction, were scarcely oxidised. A threshold value of steric hindrance of the substrate, allowed for fitting into the active site of T. villosa laccase, was extrapolated from structural information provided by X-ray analysis of T. versicolor lac3B, sharing an identity of 99% at the protein level, thus enabling us to assess the relative contribution of steric and redox properties of a substrate in determining its susceptibility to laccase oxidation. The inferred structural threshold is compatible with the distance between two phenylalanine residues that mark the entrance to the active site. Interaction of the substrate with other residues of the active site is commented on.
Qu’est-ce qu’un « paysage religieux » ? Représentations cultuelles de l’espace dans les sociétés anciennes (2010)

est assu mer plei ne ment le choix d'une inter ro ga tion qui ne part pas des cat go ries de pen se des soci ts tu dies, mais dcoule de nos propres repr sen ta tions.
Nonlinear autopilot control design fora 2-DOF helicopter model (1997)

The paper illustrates a robust control scheme for application to helicopters in vertical flight mode (both take-off and landing) to guarantee altitude stabilisation. A nonlinear helicopter model is used to derive the proposed control in which Lyapunov&apos;s direct method is used to establish the overall system stability. A recursive design technique is applied to design a nonlinear robust controller using the highly coupled system structure. It will be shown that the proposed robust controller provides semiglobal stabilisation of uniform ultimate boundedness for achieving the desired altitude. That is, the control design is valid for all values of the helicopter&apos;s collective pitch angle away from zero. The vertical flight application demonstrates a unique robust control mechanisation for helicopter and V/STOL autopilot augmentation systems.
Chemically amplified soft-x-ray resists: sensitivity, resolution, and molecular photodesorption (1993)

The sensitivity, ion photodesorption, and lithographic performance of selected novolac-based chemically amplified resists have been studied at an exposure wavelength of 140 Å. Flood exposures of the resits AZ PF514, AZ PN114, and SAL 601 yield D(0.9) values of 2.5-3.5 mJ/cm(2) for 0.25-µm-thick films. Contrast values range from 3 for AZ PN114 to 5 for SAL 601. Photodesorption of fragment ions induced by 140-Å radiation has been examined in AZ PN114 by using time-of-flight mass spectrometry and compared with poly(methylmethacrylate) (PMMA). Mass-integrated ion desorption yields from AZ PN114 are found to be ∼ 90 times less per exposure than from PMMA. Soft-x-ray projection imaging in AZ PF514 and SAL 601 has been characterized by use of a multilayer-coated 20 × Schwarzschild objective and a transmissive Ge/Si mask illuminated by a laser plasma source.
Methyltransfer von Methanol auf Co-Cobyrinate: ein Modell für die Coenzym-B12-abhängige Methyltransferase? (1998)

Mit CoI-Corrinen als Supernucleophilen gelingt die Methylierung mit Methanol bei erhöhten Temperaturen, wenn die Abgangsgruppe durch Zn2+-Ionen aktiviert wird (siehe unten). Diese Methylierungsreaktion ist das erste Modell für die Co-abhängige Methyltransferase.
CPW oscillator configuration for an electro-optic modulator (1993)

A CPW 2 GHz 3-port MESFET oscillator was designed with an electro-optic modulator application in mind. The oscillator has a self-biased gate. The source or drain ports can be used for external injection-locking. The frequency of oscillation, as well as the output power at the fundamental and first two harmonics were analyzed using a nonlinear device model and a harmonic balance technique. Comparison with measured results on a hybrid CPW oscillator fabricated on a Duroid substrate are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Facilitating the implementation of pharmacokinetic‐guided dosing of prophylaxis in haemophilia care by discrete choice experiment (2015)

To achieve implementation of individualized PK-guided dosing of prophylaxis in haemophilia, reduction of bleeding risk and reduction of costs for society should be actively discussed as they are motivating for implementation; daily dosing is still reported to be a barrier for all groups. The knowledge of these preferences will enlarge support for this innovation, and aid in the drafting of implementable guidelines and information brochures for patients, parents and professionals.
Transient customization of mobile computing infrastructure (2008)

Kimberley is a system that simplifies transient use of fixed hardware infrastructure by a mobile device. It uses virtual machine (VM) technology to resolve the tension between standardizing infrastructure for ease of deployment and maintenance, and customizing that infrastructure to meet the specific needs of a user. Kimberley decomposes the state of a customized VM into a widely-available base VM and a much smaller private VM overlay. The base is downloaded by the infrastructure in advance. Only the small overlay needs to be delivered from the mobile device, or under its control from a public web site. This strategy keeps startup delay low. It may also conserve energy on the mobile device by reducing the volume of wireless transmission. We have built a prototype of Kimberley, and our experiments confirm the feasibility of this approach.
Complement Factor 3 Is Associated With Insulin Resistance and With Incident Type 2 Diabetes Over a 7-Year Follow-up Period: The CODAM Study (2014)

Changes in C3 were associated with changes in several measures of IR and may reflect progression of metabolic dysregulation, which eventually leads to abnormalities in glucose tolerance and T2DM.
Engineering Boronsubphthalocyanine for Organic Electronic Applications (2013)

Boronsubphthalocyanines (BsubPcs) are a class of organic semiconducting materials which are relatively underdeveloped in their synthetic methods and organic semiconducting applications. A comprehensive investigation of these materials is explored in a rigorous and strategic manner progressing through each stage of the materials development cycle: materials selection from computational screening, organic/organometallic synthesis of target materials using known methods or by the development of new synthetic methods, physical and chemical analysis of new materials, and device implementation in organic light emitting diodes and organic photovoltaic cells. The result is the formation of new compositions of BsubPc specifically engineered for application as organic semiconductors in devices. &#13;\n\tSpecifically, phenoxy-boronsubphthalocyanine derivatives are investigated starting with a computational study of their molecular orbitals – a property that dictates their function (donor or acceptor behaviour) in organic electronic devices. The nature of the axial phenoxylate is found to vary the energy level of the frontier molecular orbitals minimally, by up to ~0.4 eV while the nature of the BsubPc periphery can shift the energy levels of the frontier molecular orbitals by &gt;1 eV. The differential sensitivity of the axial phenoxylate and the BsubPc periphery becomes a key design element allowing controlled adjustments of the frontier molecular orbitals by peripheral modification and isolating the design physical chemical properties essential to device fabrication to the axial phenoxylate. Subsequently, an investigation into the solubility and sublimability of these materials is performed, which leads to their investigation in OLED and OPV devices. &#13;\nThe success from the phenoxy-BsubPcs study has led to the exploration of new chemistry to expand the available axial nucleophiles beyond phenoxylates. Previously unattainable sulphur and nitrogen nucleophiles are synthesised using two methods (1) the condensation of Cl-BsubPc with phthalimides and (2) the activation of Cl-BsubPc using aluminum chloride to access thiols and anilines. The phthalimido-BsubPcs synthesized from this method are incorporated in OLEDs.
Reduction in Hemoglobin A1c with Real-Time Continuous Glucose Monitoring: Results from a 12-Week Observational Study (2007)

This observational study showed that home use of real-time GCM was safe and well tolerated and associated with a clinically and statistically significant reduction in HbA1c. Large-scale randomized, controlled outcome studies of CGM are indicated.
Simulations of Flow Ingestion and Related Structures in a Turbine Disk Cavity (2010)

Preliminary results of unsteady numerical simulations of disk cavity flow in interaction with the main gaspath flow in an axial turbine are presented in this article. A large periodic sector including vanes, blades and disk cavity of approximately 74° has been used in order to allow for the formation of large scale flow structures within the cavity. Three purge flow rates have been tested, namely no purge, low purge and high purge flow rates. Energetic large scale flow structures are detected through flow visualizations for the two lowest purge flow rates. They are found to rotate at an angular velocity slightly less than the rotor speed. The presence of the large scale structures involves important pressure perturbations inside the cavity that may lead to deep mass flow ingress, whereas the unsteady vane-blade interaction seems to cause only shallow ingress. Increasing purge flow rate appears to have a stabilizing effect on the pressure fluctuations inside the cavity and to reduce the intensity of the large scale flow structures.
Effect of Lining Papers on the Permanence of Painting Papers in Japanese Scroll Paintings During Moist Heat Ageing (2021)

A Japanese painting paper is sized with an aqueous solution of alum and animal glue followed by brushing with a mixture of pigments of various colours and aqueous animal glue solution. Subsequently, to mount the Japanese painting to a hanging scroll, the backside of the painting is lined with a first lining paper using wheat starch paste for mechanical support. To evaluate the permanence of the painting paper as a composite material in the hanging scroll, the deterioration behaviour of the unlined painting paper and the lined painting paper was compared considering the material dynamics. After moist heat accelerated ageing (80°C, 65% RH), in the sample immersed in a CuSO4・5H2O solution, cellulose was oxidised by Cu2+ to generate organic acids in the painting paper, and Cu2+ and organic acids migrated to the lining paper. Consequently, the discolouration and oxidation of the painting paper in the lined complex were relatively low compared with those of the unlined painting paper. The pH decrease in the painting paper was also small in the lined complex. Moreover, if the animal glue solution was coated on the painting paper, a buffer effect was shown to operate against the organic acids derived from the oxidation of Cu2+, thereby inhibiting the migration of Cu2+ into the lining paper. In conclusion, the presence of the lining paper inhibited the decrease in the physical strength and degree of polymerisation of the cellulose in the painting paper, thus contributing to its permanence in the lined hanging scroll.
Emulation of spin-orbit coupling for solitons in nonlinear optical media (2020)

We design a framework based on the spatial-domain copropagation of two light beams with mutually orthogonal polarizations and opposite transverse components of carrier wave vectors in a nonlinear waveguide with randomly varying birefringence, the averaging with respect to which introduces an effective Manakov nonlinearity in the system. The corresponding two-component system of nonlinear Schr\"odinger equations is derived, being similar to the system of coupled one-dimensional Gross-Pitaevskii equations for a binary spin-orbit-coupled Bose-Einstein condensate. The system may also include an effective Rabi coupling (direct linear mixing of the components) and a periodic potential, representing a photonic-crystal structure in the underlying waveguide. For self-focusing and self-defocusing signs of nonlinearity, soliton solutions of several symmetry types are obtained by means of numerical methods, and their stability is investigated, including gap solitons in the case when the periodic potential is present.
A fast algorithm for the weighted least absolute value state estimation (1991)

The weighted least absolute value minimization method is used to solve the power system state estimation problem (PSSEP). In this paper, a fast algorithm originally suggested by Barrodale and Roberts is further improved and applied to the PSSEP. The use of the developed algorithm resulted in considerable savings in computation times as demonstrated by the numerical examples given for various test systems
Exploring the coordination chemistry and reactivity of dialkylamino- and bis(dialkylamino)-phosphines in the coordination sphere of metals (2002)

The coordination chemistry of a range of dialkylamino- and bis(dialkylamino)-phosphines, RxP(NR′2)3 − x (x = 1 or 2; R = Cl, Me, Ph, C6F5; R′ = Et, Pri), 1–7, has been studied and the resulting Group 6 tetracarbonyl and platinum dichloride bis(phosphine) complexes fully characterised. Subsequently, the reactivity of the P–N bonds of the metal-bound phosphines was probed. Treatment of R″OH (R″ = Me, Et, allyl) solutions of the bis(dialkylaminodiphenylphosphine) complexes with anhydrous HCl gas led to substitution of NR′2 by OR″; the resulting P-alkoxy complexes were isolated in excellent yields. Acidification of ethylene glycol solutions of the aminophosphine complexes afforded the corresponding bis(chlorodiphenylphosphine) derivatives. Following reaction of trans-[W(CO)4(P{NEt2}Ph2)2] with either aqueous HCl or H2SO4, trans-[W(CO)4(P{OH}Ph2)2] could be isolated as its dichloromethane solvate in excellent yield (81%). Reactions of the bis(bis{dialkylamino}phenylphosphine) complexes under identical conditions yielded a range of unidentified products. Reactions of ligands 1–7 with [{RhCl(CO)2}2] and elemental selenium have been undertaken and the products used to assess the phosphines' donor capabilities. Depending on the substituents at phosphorus, either trans-diphosphine or cis-dicarbonyl complexes result from reaction with [{RhCl(CO)2}2]. The sterically demanding phosphine P(NPri2)2Ph (5) proved unreactive towards complexation with metals, although its selenide could be prepared and isolated. In order to probe the observed lack of oxidation or complexation the molecular structure P(NPri2)2(C6F5) has been determined by X-ray crystallography.
Smart smartphone development (2011)

In a remarkably short timeframe, developing apps for smartphones has gone from an arcane curiosity to an essential skill set. Employers are scrambling to find developers capable of transforming their ideas into apps. Educators interested in filling that void are likewise trying to keep up, and face difficult decisions in designing a meaningful course. There are a plethora of development platforms, but two stand out because of their popularity and divergent approaches - Apple's iOS, and Google's Android. In this paper, we will compare the two, and address the question: which should faculty teach?
Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities. (2003)

The TDSC method significantly improved the accuracy of SPECT images with a nonuniform distribution of activity highly concentrated in central regions. The value of V(3)" was significantly increased in phantom and human data, with most of the improvement derived from an increase in STR activity. This scatter correction method was approximately equally useful with data from the 6 different collimators and is recommended for more accurate quantitation of nonuniformly distributed brain activities.
Variable frequency microwave induced low temperature dopant activation in ion implanted silicon (2009)

Variable frequency microwave (VFM) anneals are used to activate ion implanted dopants and regrow the damaged silicon at temperatures between 500-550°C. Four-point-probe measurements are used to monitor the extent of dopant activation. Ion channeling analysis reveals that VFM heating removes the Si damage that results from arsenic ion implantation. Transmission electron microscopy demonstrates that the silicon lattice regains nearly all of its crystallinity after microwave processing. Secondary ion mass spectroscopy reveals limited diffusion of dopants in VFM processed samples when compared to a conventional 900°C 30 sec rapid thermal anneal.
Eight In-office Tooth Whitening Systems Evaluated In Vivo: A Pilot Study (2007)

This in vivo pilot study evaluated eight products with hydrogen peroxide (HP) concentrations ranging from 15% to 35%. The treatment contact time varied from 15 minutes to 60 minutes. Patients were evaluated for color at baseline, immediately after treatment and at one, two, four and six weeks after treatment using a colorimeter, shade guide and photos. All eight products were effective in bleaching teeth. Colorimeter data for deltaE immediately after treatment was 6.77. At one and six weeks after bleaching, there were 51% and 65% reductions in deltaE, respectively.
Design of a battery-less micro-scale RF energy harvester for medical devices (2012)

This paper presents a micro-scale RF (radio frequency) energy harvesting circuit that can be used for RF signals for milliwatt to microwatt scale DC power units. Both at hospitals and homes, radio waves are always present in our daily lives in the form of signals transmitted from TV, Radio and Mobile base stations. There are many signals of different frequencies in our surroundings that can be reclaimed via a harvester. Even though these signals carry a small amount of energy, the possibility of using that to energize devices is promising. The methodology of this work is to analyze the RF energy spectrum to identify the most available RF energy sources. Based on that we design an appropriate antenna to capture that spectral power and replicate a circuit that can convert micro-scale RF energy received via the antenna into usable electrical power. Finally, the harvester circuit is used to feed power to a table clock and successfully demonstrated. The limitations are noted along with how the system may be improved through better antenna design. This harvester design is unique in not using a battery.
Evaluating Cost Savings from Truck Caravanning (2022)

Truck platooning and related autonomous vehicle coordination concepts have been proposed as sustainable ways to increase profits and improve service quality. Recently the concept of truck caravanning, a hybrid truck platooning with only one truck driver required per platoon, has been proposed in the literature. This paper describes the research effort in developing a model that can estimate the cost savings of truck caravanning. The motivation of the proposed model is to investigate if substantial monetary savings exist to justify the initial capital investment (both in equipment and infrastructure) required for the implementation of the truck caravanning concept. A linear programming model is developed and used to evaluate different size networks. Results from numerical experiments indicate that a caravan size of four trucks or greater is needed for significant cost savings to be achieved and that driver compensation is the most critical factor dictating profitability.
Surgical and medical treatment options for urge incontinence. (2000)

As the population ages, urinary incontinence is becoming an important health issue. In the United States, urinary incontinence had an estimated annual cost of $26 billion in 1995. The author presents a literature review to inform primary care physicians about the most current medical and surgical treatment of urge incontinence. Developments in medical research have produced oral medications that are increasingly effective in controlling the symptoms of urge incontinence. This advance has resulted in a decreasing need for surgical intervention. Although surgical therapy has not been proven to be as effective as oral medications in the treatment of urge incontinence, it is still considered to be a viable therapy in select patient populations.
On-line coupling of RPLC and SFC for the analysis of chiral compounds (2018)

https://www.ilmexhibitions.com/htc/abstract/On-line+coupling+of+RPLC+and+chiral+SFC+for+the+analysis+of+pharmaceutical+compounds/378/
Protein Kinase C Mediated Anti-Proliferative Glucocorticoid-Sphinganine Synergism in Cultured Pollard III Prostate Tumor Cells (1997)

TA-induced reduction of PKC concentration coupled with sphinganine antagonism of PKC activation contributed to in a synergistic growth inhibition of an androgen resistant prostatic carcinoma.
Effects of sustained lung inflation (SLI) at birth on lung aeration during non-invasive resuscitation of preterm lambs (2018)

<b>Background:</b> SLI at birth has been shown to promote lung aeration in intubated preterm lambs (Tingay et al PedRes 2014). The effectiveness of applying SLI by full-face mask might be impaired by leaks, glottis closure, and accumulation of air in the stomach. <b>Aim:</b> To compare timing and magnitude of lung aeration at birth in preterm lambs receiving non-invasive resuscitation with and without the application of SLI. <b>Methods:</b> Preterm lambs (128d; ~28w in humans) were randomly assigned to receive SLI at birth (SLI group, n=7) or not (noSLI group, n=6). SLI group received two SLIs of 35s at 30cmH2O separated by 55s of nIPPV. All lambs received surfactant and were maintained with nIPPV (PEEP=8cmH2O, RR=60). PIP and FiO2 were adjusted to maintain PaCO2 at 35-55 mmHg and PaO2 at 60-80 mmHg up to 3h of life in both groups. Lung aeration was assessed as changes in lung reactance (Xrs) at 5Hz (Dellaca’ et al, ICM2011) measured by the forced oscillation technique. Data reported as median (IQR). <b>Results:</b> In both groups, Xrs increased with time (Figure). Xrs was significantly greater in SLI group at the end of each SLI and more variable in noSLI group. At 3h, Xrs stabilized at similar values for both groups. <b>Conclusions:</b> SLI applied non-invasively improved lung aeration and a more homogenous response in preterm lambs at birth. However, the improvements compared to CPAP disappear within few minutes.
Ambient Air Cleanup (2009)

This chapter contains sections titled: Introduction PremAir® Catalyst Systems Other Approaches