gebhart/patrepeval huggingface dataset:
Corrosion/Degradation Monitoring Technology for Composite Materials used to Extend Building Service Life (2014)

Abstract : Fiber-reinforced polymer (FRP) composites offer cost and performance advantages for patching concrete structures that have corroded reinforcing steel, but the Army largely avoids structural composite repair applications because of the lack of long-term performance data. Established composite patch inspection methods are fast but highly subjective. This report describes the demonstration of acoustic guided wave (AGW) technology as a nondestructive evaluation (NDE) methodology for assessing the condition of FRP composite structural patches. The technology uses a hand-guided rolling probe to collect ultrasonic inspection data that can then be analyzed to determine patch condition. The technology was used to evaluate more than 250 composite seismic upgrade patches installed in 1999 at historic Michie Stadium, U.S. Military Academy. The amplitude difference between the probe s emitted signal and the measured reflection provides data about bond quality and potential material defects. The technology identified five patches needing follow-up attention and possible rehabilitation. When considering costs for equipment procurement, logistics, labor, and field contingencies, an average patch-inspection time of 1.5 hours was estimated. The calculated life-cycle return on investment for this application was 11.91.
AS EXPECTATIVAS DA GERAÇÃO Y EM RELAÇÃO AO MERCADO DE TRABALHO | EXPECTATIONS OF GENERATION Y IN RELATION TO THE LABOR MARKET (2016)

A Geração Y vem quebrando paradigmas, alterando o rumo das empresas e provocando muitas controvérsias entre o antigo e o novo modelo de gestão. Eles estão gerando conflitos, discutindo as decisões das empresas e questionando as culturas organizacionais. Este estudo teve por objetivo identificar as expectativas da Geração Y em relação ao mercado de trabalho, através da apresentação de uma análise descritiva de resultados proveniente de uma pesquisa quantitativa aplicada a 33 colaboradores de uma empresa do ramo de varejo em tecnologia, na cidade de Porto Alegre/RS. Identificou-se grandes divergências neste grupo pesquisado, mas, ao mesmo tempo, convergência quanto ao que a literatura sobre a Geração Y apresenta. Destaca-se que estes jovens têm grande interesse em planejar sua carreira, procuram trabalhar em um ambiente criativo, ter qualidade de vida é fundamental, o reconhecimento de sue líder quanto ao seu trabalho é muito importante e eles buscam ter uma boa relação com seus líderes.DOI: 10.18226/23190639.v4n1.01
Electrogenerated Chemiluminescence Behavior of Graphite-like Carbon Nitride and Its Application in Selective Sensing Cu2+ (2012)

This paper reports for the first time the electrogenerated chemiluminescence (ECL) behavior of graphite-like carbon nitride (g-C(3)N(4)) with K(2)S(2)O(8) as the coreactant. The possible ECL reaction mechanisms are proposed. The spectral features of the ECL emission and photoluminescence (PL) of g-C(3)N(4) are compared, and their resemblance demonstrates that the excited states of g-C(3)N(4) from both ECL and photoexcitation are the same. The effects of K(2)S(2)O(8) concentration, pH, g-C(3)N(4)/carbon powder ratio, and scan rate on the ECL intensity have been studied in detail. Furthermore, it is observed that the ECL intensity is efficiently quenched by trace amounts of Cu(2+). g-C(3)N(4) is thus employed to fabricate an ECL sensor which shows high selectivity to Cu(2+) determination. The limit of detection is determined as 0.9 nM. It is anticipated that g-C(3)N(4) could be a new class of promising material for fabricating ECL sensors.
Does CDKN2A Loss Predict Palbociclib Benefit? (2015)

Palbociclib, an oral small-molecule inhibitor of cyclin-dependent kinases 4 and 6, was recently approved by the U.S. Food and Drug Administration in combination with letrozole for postmenopausal women with advanced hormone receptor-positive, her2-negative breast cancer. Patients with loss of CDKN2A (p16), an inherent negative regulator of cyclin-dependent kinases 4 and 6, were not separately studied because of the significant response of the patients selected based only on receptor status. Here, we report a patient with metastatic estrogen receptor- positive, her2-negative breast cancer with CDKN2A loss who experienced a clinical response to palbociclib.
Combinatory Biomarker Use of Cortical Thickness, MUNIX, and ALSFRS-R at Baseline and in Longitudinal Courses of Individual Patients With Amyotrophic Lateral Sclerosis (2018)

<b>Objective:</b> Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative process affecting upper and lower motor neurons as well as non-motor systems. In this study, precentral and postcentral cortical thinning detected by structural magnetic resonance imaging (MRI) were combined with clinical (ALS-specific functional rating scale revised, ALSFRS-R) and neurophysiological (motor unit number index, MUNIX) biomarkers in both cross-sectional and longitudinal analyses. <b>Methods:</b> The unicenter sample included 20 limb-onset classical ALS patients compared to 30 age-related healthy controls. ALS patients were treated with standard Riluzole and additional long-term G-CSF (Filgrastim) on a named patient basis after written informed consent. Combinatory biomarker use included cortical thickness of atlas-based dorsal and ventral subdivisions of the precentral and postcentral cortex, ALSFRS-R, and MUNIX for the musculus abductor digiti minimi (ADM) bilaterally. Individual cross-sectional analysis investigated individual cortical thinning in ALS patients compared to age-related healthy controls in the context of state of disease at initial MRI scan. Beyond correlation analysis of biomarkers at cross-sectional group level (<i>n</i> = 20), longitudinal monitoring in a subset of slow progressive ALS patients (<i>n</i> = 4) explored within-subject temporal dynamics of repeatedly assessed biomarkers in time courses over at least 18 months. <b>Results:</b> Cross-sectional analysis demonstrated individually variable states of cortical thinning, which was most pronounced in the ventral section of the precentral cortex. Correlations of ALSFRS-R with cortical thickness and MUNIX were detected. Individual longitudinal biomarker monitoring in four slow progressive ALS patients revealed evident differences in individual disease courses and temporal dynamics of the biomarkers. <b>Conclusion:</b> A combinatory use of structural MRI, neurophysiological and clinical biomarkers allows for an appropriate and detailed assessment of clinical state and course of disease of ALS.
Epidemiologic Trends of and Factors Associated With Overall Survival for Patients With Gastroenteropancreatic Neuroendocrine Tumors in the United States (2021)

In this study, the incidence and prevalence of GEP-NETs have continued to increase over 40 years, especially among patients with rectal GEP-NETs. In addition, this study suggests that a nomogram with 5 prognostic parameters may accurately quantify the risk of death among patients with GEP-NETs, indicating that it has satisfactory clinical practicality.
Large‐Scale Green Synthesis of Fluorescent Carbon Nanodots and Their Use in Optics Applications (2014)

An easy and green synthetic strategy for the one‐pot large‐scale preparation of carbon nanodots (C‐dots) is demonstrated. The C‐dots have a series of excellent optical features such as strong fluorescence and excitation‐wavelength‐dependent photoluminescence properties. Notably, C‐dots can be rapidly and facilely achieved on a large scale (e.g., 0.3 g C‐dots/25 min) by using cheap, accessible, and natural materials (e.g., milk, honey, silk, hair, lemon, and magnolia) as the green carbonaceous precursor. The as‐prepared C‐dots, which are shown to serve as high‐performance fluorescent stains, are superbly suitable for a variety of optics‐related applications, including in vitro and in vivo bioimaging, printing inks, and sensors. Eventually, this kind of microwave‐assisted strategy could serve as a powerful tool for synthesizing large‐scale C‐dots with strong fluorescence, holding great promise for myriad optics‐related applications.
High-resolution spatial mapping of a superconducting NbN wire using single-electron detection (2009)

Superconducting NbN wires have recently received attention as detectors for visible and infrared photons. We present experiments in which we use a NbN wire for high-efficiency (40 %) detection of single electrons with keV energy. We use the beam of a scanning electron microscope as a focussed, stable, and calibrated electron source. Scanning the beam over the surface of the wire provides a map of the detection efficiency. This map shows features as small as 150 nm, revealing wire inhomogeneities. The intrinsic resolution of this mapping method, superior to optical methods, provides the basis of a characterization tool relevant for photon detectors.
Video Summarization Based on Semantic Feature Analysis and User Preference (2008)

A personalized video summarization system is proposed in this paper. "Personalized" means that each video can be summarized according to viewer's own preference. To meet user's preference, semantic features of each frame are detected so that their relevance to user preference can be determined. Users can be also capable of setting time or frame number constraint for video summary via a friendly interface. To summarize a video efficiently and effectively, a constrained optimization problem (subject to time constraint and video smoothness) is faced and solved to determine the non-uniform sampling rates for shots relevant to user preferences. Subjective tests show that the quality of the summarized video has a MOS of about 4.0, and the comprehension about the video contents is good.
Improving the Physical Properties of Cured Rubber Compounds (2014)

No AccessHow to Improve Rubber CompoundsJan 2014Improving the Physical Properties of Cured Rubber CompoundsJohn S. DickJohn S. Dickhttps://doi.org/10.3139/9781569905340.002SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2014Pages: 9-123Print ISBN: 978-1-56990-533-3eISBN: 978-1-56990-534-0 Copyright & Permissions© 2014 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Sequential Proton Coupled Electron Transfer (PCET): Dynamics Observed over 8 Orders of Magnitude in Time (2016)

Charge transfer mechanisms lay at the heart of chemistry and biochemistry. Proton coupled electron transfers (PCET) are central in biological processes such as photosynthesis and in the respiratory chain, where they mediate long-range charge transfers. These mechanisms are normally difficult to harness experimentally due to the intrinsic complexity of the associated biological systems. Metal-peptide cations experience both electron and proton transfers upon photoexcitation, proving an amenable model system to study PCET. We report on a time-resolved experiment designed to follow this dual charge transfer kinetics in [HG3W+Ag](+) (H = histidine, G = glycine, W = tryptophan) on time scales ranging from femtoseconds to milliseconds. While electron transfer completes in less than 4 ps, it triggers a proton transfer lasting over hundreds of microseconds. Molecular dynamics simulations show that conformational dynamic plays an important role in slowing down this reaction. This combined experimental and computational approach provides a view of PCET as a single phenomenon despite its very wide time-domain span.
Handbook of glass in construction (1998)

This handbook covers uses, specifying, manufacture, and testing of sealed insulating glass units and windows. It includes all types of glass and insulation glass, including single and dual sealed systems, heat mirror materials, sealant compounds, swiggle strip and metal edge compounds.
A closed, autologous bioprocess optimized for TCR‐T cell therapies (2023)

Autologous cell therapy has proven to be an effective treatment for hematological malignancies. Cell therapies for solid tumors are on the horizon, however the high cost and complexity of manufacturing these therapies remain a challenge. Routinely used open steps to transfer cells and reagents through unit operations further burden the workflow reducing efficiency and increasing the chance for human error. Here we describe a fully closed, autologous bioprocess generating engineered TCR-T cells. This bioprocess yielded 5-12 × 10e9 TCR-expressing T cells, transduced at low multiplicity of infections, within 7-10 days, and cells exhibited an enriched memory T-cell phenotype and enhanced metabolic fitness. It was demonstrated that activating, transducing, and expanding leukapheresed cells in a bioreactor without any T-cell or peripheral blood mononuclear cell enrichment steps had a high level of T-cell purity (~97%). Several critical process parameters of the bioreactor, including culturing at a high cell density (7e6 cells/mL), adjusting rocking agitations during phases of scale-up, lowering glycolysis through the addition of 2-deoxy- d-glucose, and modulating interleukin-2 levels, were investigated on their roles in regulating transduction efficiency, cell growth, and T-cell fitness such as T-cell memory phenotype and resistance to activation-induced cell death. The bioprocess described herein supports scale-out feasibility by enabling the processing of multiple patients' batches in parallel within a Grade C cleanroom.
An Interactive Virtual Environment for 3D Model Assembly With Video Immersion (2002)

Virtual Reality (VR) applications will become increasingly important as the need to link several locations in the product development process arises. This motivates research in advanced techniques for the visualization of remotely located participants within a computer-generated environment. This research ports an existing application, which allows the assembly of predefined objects, into a virtual environment (VE). A further extension allows the user’s hands to be filmed and superimposed onto the computer-generated VE. To create this effect, live video was combined with a projection display and the “blue-box” technique. This combination enabled the texture of the hands to be untied from the background without the effort of putting up blue walls. The image is sent over the network to a high-end graphics computer generating the VE. The knowledge gained in this research will be the basis for future work on distributed multi-user access to a shared VE.
The usefulness of the reticulin stain in the differential diagnosis of liver nodules on fine-needle aspiration biopsy cell block preparations. (1997)

We reviewed fine-needle aspiration biopsy (FNAB) cell blocks of hepatocellular carcinoma (HCC) (n = 16) and benign hepatic processes (n = 16) to evaluate the significance of reticulin staining (Gomori stain) in combination with standard cytomorphologic and architectural criteria. We analyzed the staining pattern using semiquantitative grading: normal, variable, decreased, or virtually absent. Also, we graded the cell thickness of the hepatic trabeculae as greater than or less than three cells. Fourteen of 16 biopsy specimens of benign processes demonstrated a normal reticulin framework, with staining outlining hepatic trabeculae less than three cell layers in thickness. Staining was markedly decreased in one case of steatosis and virtually absent in one case of cirrhosis. In contrast, all of the 16 HCCs demonstrated either a virtually absent (7 of 16), decreased (6 of 16), or variable (3 of 16) reticulin staining pattern, with thickened trabeculae greater than three cell layers. We conclude that the reticulin stain is a useful adjunct in the differential diagnosis of liver nodules on FNAB cell block preparations and that it is particularly useful in distinguishing HCC from benign hepatic processes. Virtually absent or decreased reticulin staining and staining outlining trabeculae greater than three cells in thickness support the diagnosis of HCC. Normal reticulin staining outlining well-defined hepatic trabeculae less than three cell layers in thickness supports the diagnosis of a benign hepatic process.
Molecular and Cellular Biophysics (2006)

Molecular and Cellular Biophysics provides advanced undergraduate and graduate students with a foundation in the basic concepts of biophysics. Students who have taken physical chemistry and calculus courses will find this book an accessible and valuable aid in learning how these concepts can be used in biological research. The text provides a rigorous treatment of the fundamental theories in biophysics and illustrates their application with examples. Conformational transitions of proteins are studied first using thermodynamics, and subsequently with kinetics. Allosteric theory is developed as the synthesis of conformational transitions and association reactions. Basic ideas of thermodynamics and kinetics are applied to topics such as protein folding, enzyme catalysis and ion channel permeation. These concepts are then used as the building blocks in a treatment of membrane excitability. Through these examples, students will gain an understanding of the general importance and broad applicability of biophysical principles to biological problems.
Abstract 15654: The Hypoxia-induced Long Non-coding RNA Hyp_up_3 Regulates Alternative Splicing and Controls Angiogenesis of Endothelial Cells (2016)

RNA deep sequencing revealed that the human genome is pervasively transcribed, however, the vast majority are non-coding transcripts and belong to the class of long non-coding RNAs (lncRNAs). LncRN...
Preparation and characterization of hybrid thiol‐ene/epoxy UV–thermal dual‐cured systems (2010)

Abstract Hybrid thiol‐ene/epoxy coatings were prepared by combining thiol‐ene photo‐curable formulations with epoxy monomers, through a dual UV–thermal curing process. An increase in glass transition temperature and in storage modulus was observed for the hybrid thiol‐ene/epoxy coatings when compared with the pristine thiol‐ene UV‐cured system. Also, the bisphenol A moieties introduced into the hybrid networks during the dual‐curing process induced an increase in thermal stability of the cured materials. It has been demonstrated that the addition of epoxy monomer to the thiol‐ene photo‐curable system is a good strategy to follow in order to improve the final properties of thiol‐ene‐based coatings leading to a wide range of possible applications for the hybrid materials. Copyright © 2010 Society of Chemical Industry
Theory of dynamic critical phenomena (1977)

An introductory review of the central ideas in the modern theory of dynamic critical phenomena is followed by a more detailed account of recent developments in the field. The concepts of the conventional theory, mode-coupling, scaling, universality, and the renormalization group are introduced and are illustrated in the context of a simple example---the phase separation of a symmetric binary fluid. The renormalization group is then developed in some detail, and applied to a variety of systems. The main dynamic universality classes are identified and characterized. It is found that the mode-coupling and renormalization group theories successfully explain available experimental data at the critical point of pure fluids, and binary mixtures, and at many magnetic phase transitions, but that a number of discrepancies exist with data at the superfluid transition of $^{4}\mathrm{He}$.
Electrodissociation of high molecular weight complexes of interferon alpha during recycling isoelectric focusing. (1989)

Natural human interferon alpha has been separated by selective ultrafiltration into low molecular weight components and the molecules exceeding 100K daltons. Interferon associated with a higher molecular weight fraction showed partial pH sensitivity and resisted dissociation after treatment with urea, mercaptoethanol, sodium chloride or significant changes in pH. However, interferon activity was released from high molecular weight components during recycling isoelectric focusing. Electrodissociation was carried out in 1% ampholytes for 574 watt-hours. The interferon activity was concentrated in a pH range of 6-6.5, whereas, the majority of proteins were generally found in a more acidic position. The dissociated interferon was neutralized by polyclonal antibody to human interferon alpha (IFN alpha) and showed no presence of pH labile form. A pH sensitivity of high molecular weight interferon (HMW-IFN) may reflect an aggregation phenomenon rather than intrinsic structural differences.
Equilibrium Bids in Sponsored Search Auctions: Theory and Evidence (2013)

This paper presents a game theoretic analysis of the generalized second-price auction that the company Overture operated in 2004 to sell sponsored search listings on search engines. We construct a model that embodies few prior assumptions about parameters, and we present results that indicate that this model has under quite general assumptions a multiplicity of Nash equilibria. We then analyze bid data assuming that advertisers choose Nash equilibrium bids. We offer preliminary conclusions about advertisers' true willingness to bid for sponsored search listings. We find that advertisers' true willingness to bid is multi-dimensional and decreasing in listing position. (JEL D44, L86, M31, M37)
Spinal Cord Stimulator Explantation: Motives for Removal of Surgically Placed Paddle Systems (2017)

Inadequate pain control is the most common reason for SCSES. Advances in technology are needed to improve the quality and duration of pain control, as well as to design improvements to make the hardware more comfortable. A significant number of implants are removed due to need for MRI, a fact obviating the need for MRI-compatible systems. Patients considering SCS paddle lead placement should be counseled on the most common reasons for later explantation.
Harnessing an RNA‐mediated chaperone for the assembly of influenza hemagglutinin in an immunologically relevant conformation (2018)

A novel protein-folding function of RNA has been recognized, which can outperform previously known molecular chaperone proteins. The RNA as a molecular chaperone (chaperna) activity is intrinsic to some ribozymes and is operational during viral infections. Our purpose was to test whether influenza hemagglutinin (HA) can be assembled in a soluble, trimeric, and immunologically activating conformation by means of an RNA molecular chaperone (chaperna) activity. An RNA-interacting domain (RID) from the host being immunized was selected as a docking tag for RNA binding, which served as a transducer for the chaperna function for de novo folding and trimeric assembly of RID-HA1. Mutations that affect tRNA binding greatly increased the soluble aggregation defective in trimer assembly, suggesting that RNA interaction critically controls the kinetic network in the folding/assembly pathway. Immunization of mice resulted in strong hemagglutination inhibition and high titers of a neutralizing antibody, providing sterile protection against a lethal challenge and confirming the immunologically relevant HA conformation. The results may be translated into a rapid response to a new influenza pandemic. The harnessing of the novel chaperna described herein with immunologically tailored antigen-folding functions should serve as a robust prophylactic and diagnostic tool for viral infections.-Yang, S. W., Jang, Y. H., Kwon, S. B., Lee, Y. J., Chae, W., Byun, Y. H., Kim, P., Park, C., Lee, Y. J., Kim, C. K., Kim, Y. S., Choi, S. I., Seong, B. L. Harnessing an RNA-mediated chaperone for the assembly of influenza hemagglutinin in an immunologically relevant conformation.