gebhart/patrepeval huggingface dataset:
Lansoprazole Upregulates Polyubiquitination of the TNF Receptor-Associated Factor 6 and Facilitates Runx2-mediated Osteoblastogenesis (2015)

The transcription factor, runt-related transcription factor 2 (Runx2), plays a pivotal role in the differentiation of the mesenchymal stem cells to the osteochondroblast lineages. We found by the drug repositioning strategy that a proton pump inhibitor, lansoprazole, enhances nuclear accumulation of Runx2 and induces osteoblastogenesis of human mesenchymal stromal cells. Systemic administration of lansoprazole to a rat femoral fracture model increased osteoblastogenesis. Dissection of signaling pathways revealed that lansoprazole activates a noncanonical bone morphogenic protein (BMP)-transforming growth factor-beta (TGF-β) activated kinase-1 (TAK1)-p38 mitogen-activated protein kinase (MAPK) pathway. We found by in cellulo ubiquitination studies that lansoprazole enhances polyubiquitination of the TNF receptor-associated factor 6 (TRAF6) and by in vitro ubiquitination studies that the enhanced polyubiquitination of TRAF6 is attributed to the blocking of a deubiquitination enzyme, cylindromatosis (CYLD). Structural modeling and site-directed mutagenesis of CYLD demonstrated that lansoprazole tightly fits in a pocket of CYLD where the C-terminal tail of ubiquitin lies. Lansoprazole is a potential therapeutic agent for enhancing osteoblastic differentiation.
A* Algorithm for Multicore Graphics Processors (2010)

Graphics processors are becoming more and more popular among many application developers as commodity data-parallel coprocessors. As a consequence, general purpose programming for graphics processors research is growing. A* is a well known best-first shortest path finding algorithm, commonly used in computer games and robotics, to quickly find a good path in real time. We have implemented A* in CUDA, NVIDIA’s programming platform for graphics processors. Our graphics processor A* implementation is faster and more efficient than a similar CPU version of the same algorithm.&lt;br&gt;&lt;br&gt; \nWe have provided three improvements to the parallel A* algorithm to allow it to work faster and on larger maps. The first improvement is the use of pre-calculated paths for commonly used paths. Secondly, we allow multiple threads to work on the same path and thirdly we have implemented a scheme for Hierarchical Breakdown. Instead of computing the complete path as a whole, the path is calculated in many segments. This makes it possible to calculate more paths concurrently on big maps than was possible before. Very large maps are broken down into many clusters and paths are computed at a higher level of abstraction using path abstraction. All the segments of a path are then joined together to make a complete path using path refinements.
Discovery and Design of Family VIII Carboxylesterases as Highly Efficient Acyltransferases (2020)

Promiscuous acyltransferase activity is the ability of certain hydrolases to preferentially catalyze acyl transfer over hydrolysis, even in bulk water. However, poor enantioselectivity, low transfer efficiency, significant product hydrolysis, and limited substrate scope represent considerable drawbacks for their application. By activity-based screening of several hydrolases, we identified the family VIII carboxylesterase, EstCE1, as an unprecedentedly efficient acyltransferase. EstCE1 catalyzes the irreversible amidation and carbamoylation of amines in water, which enabled the synthesis of the drug moclobemide from methyl 4-chlorobenzoate and 4-(2-aminoethyl)morpholine (ca. 20 % conversion). We solved the crystal structure of EstCE1 and detailed structure-function analysis revealed a three-amino acid motif important for promiscuous acyltransferase activity. Introducing this motif into an esterase without acetyltransferase activity transformed a "hydrolase" into an "acyltransferase".
Does Being Bilingual in English and Chinese Influence Responses to Quality-of-Life Scales? (2002)

Bilingualism did not influence responses to a QoL scale in this large, population-based study of subjects fluent in an alphabet and/or pictogram based language.
Aerodynamic Problems of Manned Space Vehicles (1959)

The intention of this paper is to point out certain aerodynamic problems that may be of future interest, by trying to argue in general terms about their possible context. Perhaps the most distinctive feature of any project analysis of a vehicle designed to carry a man into an orbit in space and return him safely to the ground, is the need to limit the accelerations and retardations of his passage, and the temperature of his environment. There are of course innumerable other considerations which have to do with his comfort and safety, but it is his inability to withstand excessive heat or high g which distinguishes man from more rugged but less versatile instruments.
Developing Technical Expertise in Emergency Medicine—The Role of Simulation in Procedural Skill Acquisition (2008)

Developing technical expertise in medical procedures is an integral component of emergency medicine (EM) practice and training. This article is the work of an expert panel composed of members from the Society for Academic Emergency Medicine (SAEM) Interest Group, the SAEM Technology in Medical Education Committee, and opinions derived from the May 2008 Academic Emergency Medicine Consensus Conference, "The Science of Simulation in Healthcare." The writing group reviewed the simulation literature on procedures germane to EM training, virtual reality training, and instructional learning theory as it pertains to skill acquisition and procedural skills decay. The authors discuss the role of simulation in teaching technical expertise, identify training conditions that lead to effective learning, and provide recommendations for future foci of research.
Fuzzy logic in autonomous robotics: behavior coordination (2002)

Most current architectures for autonomous robots are based on a decomposition of the control problem into small units of control, or behaviors. While this decomposition has a number of advantages, it brings about the problem of having to coordinate the execution of different units in order to obtain a globally coherent behavior. In this paper, we discuss how fuzzy logic can be used, and has been used, to address this problem.
Fc block treatment, dead cells exclusion, and cell aggregates discrimination concur to prevent phenotypical artifacts in the analysis of subpopulations of tumor‐infiltrating CD11b+ myelomonocytic cells (2010)

It is well established that cancer cells can recruit CD11b(+) myeloid cells to promote tumor angiogenesis and tumor growth. Increasing interest has emerged on the identification of subpopulations of tumor-infiltrating CD11b(+) myeloid cells using flow cytometry techniques. In the literature, however, discrepancies exist on the phenotype of these cells (Coffelt et al., Am J Pathol 2010;176:1564-1576). Since flow cytometry analysis requires particular precautions for accurate sample preparation and trustable data acquisition, analysis, and interpretation, some discrepancies might be due to technical reasons rather than biological grounds. We used the syngenic orthotopic 4T1 mammary tumor model in immunocompetent BALB/c mice to analyze and compare the phenotype of CD11b(+) myeloid cells isolated from peripheral blood and from tumors, using six-color flow cytometry. We report here that the nonspecific antibody binding through Fc receptors, the presence of dead cells and cell doublets in tumor-derived samples concur to generate artifacts in the phenotype of tumor-infiltrating CD11b(+) subpopulations. We show that the heterogeneity of tumor-infiltrating CD11b(+) subpopulations analyzed without particular precautions was greatly reduced upon Fc block treatment, dead cells, and cell doublets exclusion. Phenotyping of tumor-infiltrating CD11b(+) cells was particularly sensitive to these parameters compared to circulating CD11b(+) cells. Taken together, our results identify Fc block treatment, dead cells, and cell doublets exclusion as simple but crucial steps for the proper analysis of tumor-infiltrating CD11b(+) cell populations.
Femoral Cortical Suspension Devices for Soft Tissue Anterior Cruciate Ligament Reconstruction (2012)

Adjustable-length loop devices may need to be retensioned after cycling the knee and fixing the tibial side to account for the increased initial displacement seen with these devices.
Biventricular adaptation to volume overload in mice with aortic regurgitation (2009)

Hypercholesterolemia causes aortic valve regurgitation with moderate prevalence in mice. When present, aortic valve regurgitation causes volume overload and pathological remodeling of both ventricles.
Finite elements and clinical analysis of the reconstruction of calcaneu s deficits with three kinds of bone flaps (2005)

Objective To analyze the finite elements and clinical results of three kinds of bone transplan-tation to reconstruct calcaneus deficits.Methods The shortages of calcaneus were simu lated and rebuilt with ili-um,fibula,scapula,respectively.The displacements and stresses calc ulated by the finite element analysis were used as the indexes of estimation of foot f unctions.The clinical effects of 8c ases of reconstruction of calcaneus deficits with vascularized bone flaps were also ev aluated.Results According to the results of the finit e element analysis,the foot functions were influenced mostly by the deficits of calcaneus.The v alue of USUM was 3.535mm,which was434-fold higher than that of the norm al foot,while the value of VON was 154.372MPa,50-fold higher than that of the normal.The values of USUM and VON reb uilt by ilium were less than those by f ibula and scapula.Various progress es were made in foot function after clin ical reconstruction.Relatively sa tisfactory results were gained in th ose repaired by iliac transfer.Conclusion The deficit of calcaneus should be re constructed and the ilium is preferred in the re-spects of mechanics and clinic effect.[
INTRODUCTION OF THE AMERICAN/ASIAN GENOTYPE OF DENGUE 2 VIRUS INTO THE YUCATAN STATE OF MEXICO (2004)

A dengue (DEN) outbreak occurred in the Yucatan State of Mexico in 2002. Three isolates were obtained from patients presenting with DEN-like symptoms, and examined by partial nucleotide sequencing and phylogenetic analysis. The isolates were identified as DEN-2 viruses of the American-Asian genotype; this is the first report of this genotype in the Yucatan State. The DEN-2 viruses of the American-Asian genotype have been associated with more severe disease outcomes. Thus, its introduction into the Yucatan State presents a serious problem to public health authorities. During this outbreak, DEN virus infection was confirmed in 18% (282 of 1,560) of the patients who presented with DEN-like symptoms. Of these, 87 (31%) patients met the World Health Organization criteria for dengue hemorrhagic fever, including two patients who died. The majority (77%) of the patients experienced secondary infections in this epidemic.
Microstructure and Texture Evolution During Annealing of Plane Strain Compressed Al and Al-1%Mn Alloy Single Crystals (2011)

The microstructure and the texture evolutions of partly recrystallized samples of pure Al and the Al-1%wt.Mn alloy have been characterized by a high resolution SEM/EBSD. The single crystals of the Goss{110}<001> and brass{110}<112> orientations, stable in the plane strain compression, were deformed in a channel-die up to 60% to develop a homogeneous structure composed of two sets of symmetrical primary microbands and then shortly annealed. It is documented that the orientations of the initial nucleus were scattered but not accidental. The disorientation axes in the orientation relationship across the recrystallization front usually coincide with one of the <112>, <221>, <102> or <111> crystallographic directions and were rather rarely close to the <110> or <001> directions. The disorientation axis of the <111>-type is only one of the few most often observed.
Bundling mobile base station and wireless energy transfer: Modeling and optimization (2013)

Wireless energy transfer is a promising technology to fundamentally address energy and lifetime problems in a wireless sensor network (WSN). On the other hand, it has been well recognized that a mobile base station has significant advantages over a static one. In this paper, we study the interesting problem of co-locating the mobile base station on the wireless charging vehicle (WCV). The goal is to minimize energy consumption of the entire system while ensuring none of the sensor nodes runs out of energy. We develop a mathematical model for this complex problem. Instead of studying the general problem formulation (OPT-t), which is time-dependent, we show that it is sufficient to study a special subproblem (OPT-s) which only involves space-dependent variables. Subsequently, we develop a provably near-optimal solution to OPT-s. The novelty of this research mainly resides in the development of several solution techniques to tackle a complex problem that is seemingly intractable at first glance. In addition to addressing a challenging and interesting problem in a WSN, we expect the techniques developed in this research can be applied to address other related networking problems involving time-dependent movement, flow routing, and energy consumption.
Glycolipids as Receptors for Bacillus thuringiensis Crystal Toxin (2005)

The development of pest resistance threatens the effectiveness of Bacillus thuringiensis (Bt) toxins used in transgenic and organic farming. Here, we demonstrate that (i) the major mechanism for Bt toxin resistance in Caenorhabditis elegans entails a loss of glycolipid carbohydrates; (ii) Bt toxin directly and specifically binds glycolipids; and (iii) this binding is carbohydrate-dependent and relevant for toxin action in vivo. These carbohydrates contain the arthroseries core conserved in insects and nematodes but lacking in vertebrates. We present evidence that insect glycolipids are also receptors for Bt toxin.
Turning Industrial Baker's Yeast Manufacture into a Powerful Zero Discharge Multipurpose Bioprocess (2017)

Commercial baker's yeast—a low-cost product with a low profit margin—requires complex fermentation techniques (large-scale, fed-batch fermentation) and is subject to strict quality safety regulations. Large amounts of molasses, ammonia, and vitamins, as well as air and water (liquid and steam) are necessary for the efficient industrial production of baker's yeast. The associated production costs are strongly correlated to the increasing and volatile market price for molasses. In this regard, producers mainly concentrate their efforts on the search for alternative sugar sources and the further improvement of bioprocess control and efficiency. As industrial baker's yeast production has been optimized over many decades, there is only little room left for such improvements. New, interesting trends regarding baker's yeast production have been recently drafted by different research groups and are reviewed in this paper. Subsequently, we combined these multidisciplinary advances in an innovative strategic concept and demonstrated how industrial baker's yeast biomanufacture can be turned into a powerful, zero-discharge multipurpose bioprocess. As a result, the redesigned bioprocess provides a large amount of district heat as well as key molecules such as invertase and betaine. It uses side streams from the food industry as carbon and nitrogen sources and strongly relies on state-of-the-art membrane technology. The presented approach aims to show how industrial aerobic processes can be employed within a sustainable industrial environment.
Les champignons marins et leurs applications biotechnologiques (2019)

Les communautés fongiques des fonds marins, très diversifiées et plus ou moins atypiques, jouent un rôle essentiel dans les cycles biogéochimiques. Quelles sont les biomolécules produites par ces organismes et comment les valoriser dans les domaines de la biotechnologie ?
Generalized fiber Fourier optics (2011)

A twofold generalization of the optical schemes that perform the discrete Fourier transform (DFT) is given: new passive planar architectures are presented where the 2 × 2 3 dB couplers are replaced by M × M hybrids, reducing the number of required connections and phase shifters. Furthermore, the planar implementation of the discrete fractional Fourier transform (DFrFT) is also described, with a waveguide grating router (WGR) configuration and a properly modified slab coupler.
Altered functional coupling of coronary K+channels in diabetic dyslipidemic pigs is prevented by exercise (2003)

Chronic hyperglycemia and hypercholesterolemia have been shown to alter ionic currents in vascular smooth muscle. We tested the hypothesis that the combined effect of hyperglycemia and hyperlipidemia (diabetic dyslipidemia) would increase the Ca2+-sensitive K+ (KCa) current as a compensatory response to an increase in intracellular Ca2+ concentration. We also hypothesized that exercise training would prevent this elevation in KCa current. Miniature Yucatan swine were randomly assigned to five groups: control, standard pig chow (C, n = 6); hyperlipidemic, high-fat pig chow (H, n = 5); diabetic, standard pig chow (D, n = 7); diabetic, high-fat pig chow ("diabetic dyslipidemic," DD, n = 12); and exercise-trained DD (DDX, n = 9). High-fat chow consisted of standard minipig chow supplemented with cholesterol (2%) and coconut oil. Increased coronary vasoconstriction assessed in vivo and in vitro in DD was prevented by exercise. Patch-clamp experiments performed on right coronary artery smooth muscle cells resulted in greater K+ current densities in the H, D, and DD groups vs. the DDX group between -10 and 40 mV. In fura 2-loaded cells, current activated by caffeine-induced Ca2+ release was greater in H, D, and DD compared with C and DDX (P < 0.05), whereas intracellular Ca2+ concentration was not different across groups. Finally, there were no differences in the KCa or Kv channel protein content between groups. These data indicate that hyperglycemia, hyperlipidemia, and diabetic dyslipidemia lead to elevated whole cell K+ current and increased functional coupling of KCa and Ca2+ release. Endurance exercise prevented increased coupling of Ca2+ release to KCa channel activation in diabetic dyslipidemia.
Evidence for the identity of anti‐proteinase pulmonary protein CCSP and uteroglobin (1988)

Purified Clara cell secretory protein (CCSP) from rabbit lung was analyzed by SDS gel electrophoresis, and immunoblotting with a specific anti-uteroglobin antibody as well as for its ability to bind [3H]progesterone. The results obtained indicate that proteins CCSP and uteroglobin are identical.
Computer decision aiding under soft boundaries with application to freight train dispatching (1993)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1994.
Field emission excitation of a high pressure noble gas (2016)

Electric Hybrid Lasers (EHL) combines the benefits of a solid state laser (SSL) and a gas phase system. EHLs have the electrical capacity of an SSL and the thermal management and beam quality of a gaseous lasing medium. Researchers at Emory University have developed a novel EHL.1 A three-level EHL is being developed that utilizes a capacitively coupled RF discharge to produce metastable excited states of a Noble gas to and from the ground state of the laser. The lowest meta-stable state is optically pumped by employing diodes resonant with the highest energy state and then is spin mixed to transition to the lasing state. The atom then lases back to the beginning meta-stable state. To improve upon the efficiency of the capacitively coupled RF discharge for producing the meta-stable ground state, a new approach for producing meta-stables is investigated utilizing field emission into a high pressure Noble gas. If the electric field to pressure (E/P) ratio is kept sufficiently low, ions and electrons produced via ionization is negligible. The low E/P ratio is achieved due to the low turn-on electric field for the field emitters, thus the majority of the electrons in the gas are due to field emission, resulting in a highly non-neutral plasma. Experimental results have shown that individual field emission fibers can produce relatively high current of greater than a micro-Amp at extremely low electric fields (160 kV/m). In addition, experimental results show that at lower currents, the current-voltage characteristic is consistent with Fowler-Nordheim emission. At higher current levels, the current-voltage characteristic enters into a space charge limited regime where current increases as the square of the voltage. Excitation of the Argon gas using field emission was accomplished and spectroscopic measurements of the optical emission were made showing the lasing state was excited and relaxed to the ground meta-stable state. PIC simulations were able to reproduce the same trends observed in the experimental results. Experimental results showed that Argon meta-stables could be produced at E/P ratios well below what could be used to sustain a standard plasma discharge.
Smooth Quantum Hydrodynamic Model Simulationof the Resonant Tunneling Diode (1998)

Smooth quantum hydrodynamic (QHD) model simulations of the resonant tunneling diode are presented which exhibit enhanced negative differential resistance (NDR) when compared to simulations using the original O ( ℏ 2 ) QHD model. At both 300 K and 77 K, the smooth QHD simulations predict significant NDR even when the original QHD model simulations predict no NDR.
Solid-State Structural Analysis of the “Naked” Isodicyclopentadienide Anion. (1998)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionSolid-State Structural Analysis of the "Naked" Isodicyclopentadienide Anion.Judith C. Gallucci, Olivier Gobley, Florence Zaegel, Philippe Meunier, Bernard Gautheron, Holger Lange, Rolf Gleiter, Natasha Kozmina, and Leo A. PaquetteCite this: Organometallics 1998, 17, 10, 2134Publication Date (Web):April 22, 1998Publication History Published online22 April 1998Published inissue 1 May 1998https://pubs.acs.org/doi/10.1021/om9802515https://doi.org/10.1021/om9802515correctionACS PublicationsCopyright © 1998 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views239Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (19 KB) Get e-Alertsclose Get e-Alerts