gebhart/patrepeval huggingface dataset:
Isolation and Identification of Sialylated Glycopeptides from Bovine α1-Acid Glycoprotein by Off-Line Capillary Electrophoresis MALDI-TOF Mass Spectrometry (2006)

Sialylated glycopeptides contained in liquid chromatographic fractions of bovine alpha1-glycoprotein tryptic digests were isolated from asialo peptides using capillary electrophoresis (CE). CE effluents were deposited directly onto a metallic target and analyzed using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. This method allowed the characterization of four N-glycosylation sites in the glycoprotein, and each site was observed as a set of sialylated peptide glycoforms. Tandem mass spectrometry was used to confirm peptide sequences and glycan content in glycoforms. The CE method developed for this study resulted in a very clear separation of the sialylated from the asialo content of glycoprotein digests and proved very useful in the determination of the nature and location of sialylated glycans along the protein chain. This article is the first report describing the use of on-target CE fraction collection using a MALDI removable sample concentrator.
Photonic crystal embedded waveguide for compact C-band band-pass filter (2018)

We report the modelling of a band-pass filter at conventional band (c-band) and the effect of different shapes of photonic crystal (PhC) holes embedded on silicon-on-insulator (SOI) waveguide. The designed embedded waveguides was simulated with LUMERICAL finite different time domain (FDTD) and a filter response with a bandwidth of approximately 30 nm complying with international telecommunication unit (ITU-T) standard was observed. The simulated bandwidth observed was sufficient for guarding against other band interference in telecommunication applications such as wavelength division multiplexing (WDM). The waveguide was designed with a dimension of 600 nm width × 260 nm height and embedded with PhC of 4 mirrors and 3 cavities. 2 mirrors at both end of the whole structure were designed with less number of holes for obtaining the band-pass filter profile. With a value of lattice constant a, hole radius r and cavity distance c of 370, 115 and 315 nm respectively, the simulated device spectrum complimented the erbium doped fiber amplifier (EDFA) spectrum to obtain wavelength profile flatness. The PhC embedded waveguide was tailored to give a 70 percent value of transmission. A flat profile was observed by reducing the photonic crystal hole radii in the middle mirrors. The wavelength band and the bandwidth of the band can be tuned by manipulating the number of mirrors and cavities in waveguide. A different types of PhC hole shapes were also studied and compared. The transmission quality and bandpass quality with different types of hole shapes show that the circular PhC shape are superior in comparison with square hole shapes.
한국채택국제회계기준 도입 전과 후의 재무비율 비교 (2013)

본 연구는 2011년 한국채택국제회계기준을 적용한 유가증권시장 상장 기업을 대상으로 종전의 기업회계기준(K－GAAP)을 적용한 개별재무제표와 연결재무제표의 각각의 재무비율과 현행 한국채택국제회계기준(K－IFRS)을 적용한 개별재무제표와 연결재무제표의 각각의 재무비율에 어떠한 차이가 있는지 실증분석한다. K－GAAP을 이용한 재무비율과 K－IFRS를 이용한 재무비율간의 차이를 분석하기 위하여 이론연구와 선행연구를 통하여 가설을 설정하고 이를 검정하기 위해 집단간 t－검정을 통하여 가설검정을 실시하였다. 추가적인 분석으로 KGAAP에서 K－IFRS로의 변동차이 분석을 실시하였다. 가설검정 결과, 개별재무제표를 작성한 기업을 대상으로 한 총자산증가율에 있어서만을 제외하고 전체적으로 모든 비율에서 K－IFRS의 도입 전과 후의 재무비율간에는 통계적으로 유의한 차이가 없는 것으로 나타났다. 그러나 2011년의 유가증권시장의 공시 기업을 대상으로한 본 연구와 총자산증가율, 유동비율, 부채비율, 자기자본순이익률, 재고자산회전율에 있어 조기도입기업만을 대상으로 한 선행연구들과는 상이한 결과를 도출하였다.
Repurposing itraconazole as an anticancer agent (2017)

Itraconazole, a common anti-fungal agent, has demonstrated potential anticancer activity, including reversing chemoresistance mediated by P-glycoprotein, modulating the signal transduction pathways of Hedgehog, mechanistic target of rapamycin and Wnt/β-catenin in cancer cells, inhibiting angiogenesis and lymphangiogenesis, and possibly interfering with cancer-stromal cell interactions. Clinical trials have suggested the clinical benefits of itraconazole monotherapy for prostate cancer and basal cell carcinoma, as well as the survival advantage of combination chemotherapy for relapsed non-small cell lung, ovarian, triple negative breast, pancreatic and biliary tract cancer. As drug repurposing is cost-effective and timesaving, a review was conducted of preclinical and clinical data focusing on the anticancer activity of itraconazole, and discusses the future directions for repurposing itraconazole as an anticancer agent.
Tunable, bioactive protein conjugated hyaluronic acid hydrogel for neural engineering applications (2016)

Millions of Americans suffer from nervous system injuries. Hydrogels have been investigated to (1) bridge nerve gaps; (2) act as scaffolds for bioactive molecule delivery or cell transplantation; and/or (3) promote axonal outgrowth. In this study, we use a rapid, one-step Michael addition click chemistry reaction to fabricate a hyaluronic acid (HA) scaffold for neural repair. Briefly, some of the primary hydroxyl groups on the HA backbone were modified with vinyl sulfone functional groups for (1) conjugation of thiol based bioactive molecules and (2) hydrogel crosslinking, which was confirmed by proton nuclear magnetic resonance (<sup>1</sup>H-NMR) and Fourier transform infrared spectroscopy (FTIR). The degree of crosslinking creates a mechanically tunable hydrogel. Rheology confirmed that the storage modulus was within the order of magnitude to that of nervous tissue. Primary human dermal fibroblasts and primary mouse neural stem cells (NSCs) seeded in the HA hydrogel were viable and proliferative, thus demonstrating that the HA hydrogel is suitable as a scaffold for cell transplantation. The range of pore size demonstrated that the scaffold supports cell migration and neurite extension. Neurite outgrowth of cultured whole embryonic day 9 chick dorsal root ganglions signifies that the hydrogel supports axonal outgrowth. Reduction in immune and inflammatory cell viability was observed in the anti-Fas conjugated HA hydrogel, whereas the NSCs maintained viability in the anti-Fas HA hydrogel. Therefore, this one-step, rapid, controllable reaction is an efficient method for fabrication of tunable, biomolecule conjugated hydrogels for neural engineering applications.
Nanoarchitectures. 6. Liquid Crystals Based on Shape-Persistent Macrocyclic Mesogens. (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNanoarchitectures. 6. Liquid Crystals Based on Shape-Persistent Macrocyclic Mesogens.Jinshan Zhang and Jeffrey S. MooreCite this: J. Am. Chem. Soc. 1994, 116, 6, 2655–2656Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/ja00085a070https://doi.org/10.1021/ja00085a070research-articleACS PublicationsRequest reuse permissionsArticle Views879Altmetric-Citations145LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Multipoint methylation analysis indicates a distinctive epigenetic phenotype among testicular germ cell tumors and testicular malignant lymphomas (2003)

Hypermethylation of tumor-suppressor genes has been implicated in the pathogenesis of human cancers. Although a growing number of genes showing hypermethylation is being reported in human cancer, methylation profiles of tumor-related genes in testicular neoplasms have not been well elucidated. This study was designed to show the methylation profiles of multiple CpG islands in testicular germ cell tumors (TGCTs) in comparison with those in testicular malignant lymphomas. We studied the methylation status of E-cadherin, CDKN2B, CDKN2A, BRCA1, RB1, VHL, RASSF1A, RARB, and GSTP1 by use of TGCT tissues and testicular malignant lymphoma tissues (25 primary TGCT tissues and three primary testicular lymphoma tissues). Methylation was not observed in E-cadherin, CDKN2B, CDKN2A, BRCA1, RB1, VHL, RASSF1A, RARB, and GSTP1 in any of the TGCT tissues. In contrast, all three (100%) of the testicular lymphoma tissues demonstrated hypermethylation of E-cadherin, RASSF1A, and RARB, but not CDKN2B, CDKN2A, BRCA1, RB1, VHL, and GSTP1. These data demonstrate that a distinctive epigenetic phenotype underlies the TGCTs and testicular lymphomas at the CpG sites of E-cadherin, RASSF1A, and RARB; a distinctive epigenetic phenotype was not observed among seminomatous TGCTs and non-seminomatous TGCTs at the CpG sites examined.
Passive-only damage detection by reciprocity of Green’s functions reconstructed from diffuse acoustic fields with application to wind turbine blades (2014)

The increasing demand for renewable and clean power generation has resulted in the increased size of rotor blades in wind turbine systems. The operational environments have introduced the need for structural health monitoring of the blades to help prevent unexpected failures. A new passive approach is here presented to detect damage in a wind turbine blade using the reciprocity of Green’s function. This is achieved using the derivative of an ensemble average of cross-correlation functions to reconstruct the forward and backward time-domain Green’s functions between any two detection points on the structure within a diffuse acoustic field. Damage is detected when the similarity between the forward and backward signals decreases due to the wave nonlinearities introduced by the discontinuity that break the field reciprocity condition. Proof-of-principle results are presented first for an aluminum plate and then for a 9-m-long composite wind turbine blade containing known, simulated damage.
T132. ASSESSMENT OF CROSS-NATIONAL EQUIVALENCE OF THE COMMUNITY ASSESSMENT OF PSYCHIC EXPERIENCES (CAPE) (2018)

The Community Assessment of Psychic Experiences (CAPE) is a self-report questionnaire that has been developed to measure the dimensions of psychosis in the general population. The cross-national equivalence of a questionnaire allows the comparability of a scale across different populations in different countries, i.e., using different versions of the scale according to the considered language. In this study, our aim was to investigate the equivalence of the CAPE across different countries. Data were drawn from the European Union Gene-Environment Interaction (EU-GEI) study. Participants (incident case of psychotic disorder, controls and siblings of cases) were recruited across in six countries: United Kingdom, the Netherlands, Italy, Spain, Brazil and France. To analyse the cross-national equivalence of the dichotomised version of the CAPE, we used the multigroup categorical confirmatory factory analysis (MCCFA). The cross-national equivalence can be stated after the establishment of three invariances characterised by increased constraints: the configural invariance, the metric invariance and the scalar invariance across the multiples groups. The configural invariance model fits well, providing evidence for identical factor structure across countries. The assumption that factor loadings are identical across countries is granted based on the negligible change in the fit indices in the metric invariance model. Moreover, the fit indices suggest that the CAPE shows scalar invariance across countries. These findings suggest that comparisons across countries of factor and observed means of the CAPE are possible. Thus, differences observed in scores between samples from different countries can be considered as different levels of psychosis.
Glucose-Regulated Proinsulin Processing in Isolated Islets From Rat Pancreas (1988)

We demonstrated previously that the conversion rate of proinsulin to insulin in pancreatic islets progressively increased after prolonged prior exposure to glucose (11 mM) and that this effect could be blocked by cycloheximide. This study was designed to characterize further the time course and regulation of the proinsulin conversion process. The effects of prior exposure to glucose on proinsulin conversion were dose dependent (Km, approximately 7 mM glucose) and time dependent, taking approximately 3 h to reach the maximum rate. Glucose added at or after the subsequent [3H]leucine pulse was ineffective. Mannoheptulose, added during a 3-h exposure with glucose (11 mM), prevented glucose-induced activation of the proinsulin conversion process. L-Leucine (20 mM) was as effective as 11 mM glucose in activating conversion, whereas 2-alpha-ketoisocaproic acid (20 mM) or phorbol ester (50 nM) had little effect. Activation of proinsulin conversion by a 24-h exposure to glucose (11 mM) was reversed by a subsequent 3-h prior exposure to cycloheximide. alpha-Amanitin, an inhibitor of mRNA synthesis, did not influence the glucose-induced activation of proinsulin conversion when present during a 3-h exposure to glucose; however, it completely inhibited glucose-stimulated conversion when present during 24 h exposure. Results suggest that activation of the proinsulin conversion process is regulated by glucose metabolism rather than the glucose molecule per se and that other, but not all, secretagogues are effective. Conversion may require prior synthesis of a pool of converting enzyme(s) or other regulatory proteins whose turnover is relatively rapid (approximately 33 h) and whose mRNA is more stable (to 24 h).
Learning Blood Oxygen from Respiration Signals (2021)

Monitoring blood oxygen is critical in a variety of medical conditions. For almost a century, pulse oximetry has been the only non-invasive method for measuring blood oxygen. While highly useful, pulse oximetry has important limitations. It requires wearable sensors, which can be cumbersome for older patients. It is also known to be biased when used for dark-skinned subjects. In this paper, we demonstrate, for the first time, the feasibility of predicting oxygen saturation from breathing. By eliminating the dependency on oximetry, we eliminate bias against skin color. Further, since breathing can be monitored without body contact by analyzing the radio signal in the environment, we show that oxygen too can be monitored without any wearable devices. We introduce a new approach for leveraging auxiliary variables via a switcher-based multi-headed neural network model. Empirical results show that our model achieves good accuracy on multiple medical datasets.
Preparation of Granular Ceramic Filter and Prediction of Its Collection Efficiency (2014)

The silicon carbide (SiC) ceramic filter is the most favorable component to remove particulate matter from hot flue gas due to its high filtration efficiency and high thermal durability. The effect of SiC powder size on the physical properties and filtration performance to prepare high-performance granular ceramic filter media was investigated in this study. Disk-type filter media were prepared by mixing ceramic components followed by physical compression and sintering. The porosity and average pore diameter in the filter media increased with increasing powder size. However, the mechanical strength decreased with increasing powder size, while it increased with increasing physical compressive force. The filter performance factor, qFM was introduced to evaluate the ceramic filter properties, and the SiC50 filter was the best of the ceramic filters prepared in this study. We also found that diffusion was a dominant collection mechanism for particles smaller than 0.7 μm, and direct interception and inertia were dominant collection mechanisms for particles larger than 0.7 μm in the SiC50 filter based on a single collector efficiency model. In addition, the predicted collection efficiencies showed reasonably good agreement with the experimental ones.Copyright 2014 American Association for Aerosol Research
Design Analysis for Lunar Safe Haven Concepts (2022)

View Video Presentation: https://doi.org/10.2514/6.2022-1567.vid NASA’s plan to return humans to the lunar surface faces many challenges, especially in the sustained phases of the Artemis program. In combination with a habitat, a Lunar Safe Haven (LSH) would provide additional protection to crew, electronics, and equipment from the hazards of the space environment such as radiation, thermal extremes, micrometeoroids, and lunar dust. Influenced by the NASA Artemis program goals, the Lunar Safe Haven Study defined the high-level requirements, outlined the trade space for a LSH concept, and evaluated a set of concepts using a decision analysis structure. This paper will provide additional detail for two concepts that were designed and evaluated during the LSH study, the logic behind the choices, and some of the main driving design parameters.
Ab-Initio Calculation of Spectral Absorption Coefficients in Molten Fluoride Salts with Metal Impurities (2018)

Molten salts have been proposed as coolants for numerous advanced reactor designs. It is envisioned that these reactors, both fluoride-salt–cooled high-temperature reactors and molten-salt–fueled reactors will operate at high temperatures, where the radiative heat transfer properties of the salts may be required for accurate heat transfer analysis. Experimental challenges have prevented the measurement of absorption coefficients in most salts. In an attempt to fill this gap in data, the Vienna Ab-Initio Simulation Package is used in the present research to calculate the absorption coefficient resulting from photoelectric interactions in numerous molten salts. Ab-initio molecular dynamics is used to generate the amorphous structures of a variety of salts. The pure halide salts LiF, FLiNaK, and FLiBe, are shown to be optically clear through a wide portion of the electromagnetic spectrum. Conversely, the transition metal fluoride salt KF-ZrF4 is shown to be substantially opaque. As chromium is a known impurity of concern from the corrosion of steels in reactor environments, the effect on absorption of low levels of chromium in an otherwise transparent salt is investigated and found to significantly increase absorption at relevant wavelengths.
The Impact of a Dedicated Sedation Team on the Incidence of Complications in Pediatric Procedural Analgosedation (2022)

The number of pediatric procedural sedations for diagnostic and minor therapeutic procedures performed outside the operating room has increased. Therefore, we established a specialized interdisciplinary team of pediatric anesthesiologists and intensivists (Children’s Analgosedation Team, CAST) at our tertiary-care university hospital and retrospectively analyzed the first year after implementation of the CAST. Within one year, 784 procedural sedations were performed by the CAST; 12.2% of the patients were infants <1 year, 41.9% of the patients were classified as American Society of Anesthesiologists (ASA) grade III or IV. Most children received propofol (79%) and, for painful procedures, additional esketamine (48%). Adverse events occurred in 51 patients (6.5%), with a lack of professional experience (OR 0.60; 95% CI 0.42−0.81) and increased propofol dosage (OR 1.33; 95% CI 1.17−1.55) being significant predictors. Overall, the CAST enabled safe and effective procedural sedation in children outside the operating room.
THE METABOLISM IN VIVO OF GLYCINE AND SERINE IN EIGHT AREAS OF THE RAT CENTRAL NERVOUS SYSTEM1 (1970)

Abstract— Results of studies designed to estimate the rates at which glycine is derived from various possible sources in discrete areas of the rat CNS are reported. These results suggest that glycine is derived predominantly by de novo synthesis, presumably via the established pathways leading from glucose through serine to glycine. The content of glycine ranged from a low of approximately 0‐6 μmol/g in the cerebellum and telencephalon to a high of 5·5 μmol/g in the spinal cord grey matter; however, based on its estimated rate of synthesis from serine, there appeared to be no correlation between the content of glycine and its rate of synthesis in the various areas studied. The flux of glycine from blood into the CNS was slower (0·03‐0·15 μmol/g/h depending on the CNS structure) than that of serine (0·15‐0·23 μmol/g/h) and both amino acids entered various CNS areas at rates unrelated to their respective tissue contents. These data have been discussed with regard to the putative transmitter function of glycine in the spinal cord and brainstem.
Estimating methodology for a large regional application of conservation voltage reduction (1990)

The authors describe a supply-curve methodology that can determine the conservation value of CVR (conservation voltage reduction) applied to many distribution systems in a region. It is shown that, in the area served by Bonneville Power Administration involving approximately 150 utilities, the systematic implementation of CVR could conserve between 170 and 268 average Megawatts at a cost of 5 cents/kWh. A large portion of this CVR resource would be available at less than 1 cent/kWh (142 to 230 AMW). The intermediate estimate of the regional CVR resource at 1 cent/kWh (179 AMW) exceeds the conservation potential (150 AMW) that is possible at the same cost from implementing major efficiency improvements (reconductoring, transformer replacement, and voltage upgrading) on Pacific Northwest transmission and distribution systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Programmed Polyene Cyclization Enabled by Chromophore Disruption (2022)

A new polyene cyclization strategy exploiting β-ionyl derivatives was developed. Photoinduced deconjugation of the extended π-system within these chromophores unveils a contrathermodynamic polyene that engages in a Heck bicyclization to afford [4.4.1]-propellanes. This cascade improves upon the limited regioselectivity achieved using existing biomimetic tactics and tolerates both electron-rich and electron-deficient (hetero)aryl groups. The utility of this approach was demonstrated with the diverted total synthesis of taxodione and salviasperanol, two isomeric abietane diterpenes that were previously inaccessible along the same synthetic pathway.
Bioactive 1,2,3‐Triazoles: An Account on their Synthesis, Structural Diversity and Biological Applications (2021)

The triazole heterocycle is a privileged scaffold in medicinal chemistry, since its structure is present in a large number of biologically active molecules, including several drugs currently in the market. Due to their vast applications, a wide variety of methods are described for their preparation, such as the 1,3-dipolar cycloaddition and processes involving diazo compounds and diazo transfer reactions. Considering the significant number of contributions from our research group to this chemistry in recent decades, in this account we discuss both the development of new methods for the synthesis of 1,2,3-triazoles and the preparation of new triazole-functionalized biologically active molecules using classical approaches.