gebhart/patrepeval huggingface dataset:
Synthesis, Structure−Activity Relationships, and Molecular Modeling Studies of N-(Indol-3-ylglyoxylyl)benzylamine Derivatives Acting at the Benzodiazepine Receptor, (1996)

A number of N-(indol-3-ylglyoxylyl)benzylamine derivatives were synthesized and tested for [3H]flunitrazepam displacing activity in bovine brain membranes. Some of these derivatives (9, 12, 14, 15, 17, 27, 34, 35, 38, 41, and 45) exhibited high affinity for the benzodiazepine receptor (BzR) with Ki values ranging from 67 to 11 nM. The GABA ratio and [35S]-tert-butylbicyclophosphorothionate binding data, determined for the most active compounds, showed that they elicit an efficacy profile at the BzR which depends on the kind of substituent present on the phenyl ring of the benzylamine moiety. Moreover, lengthening (propylamine derivatives 1-3) and shortening (aniline derivatives 46-54) of the distance between the phenyl ring and the amide group of the side chain gave compounds with a drastically lower binding potency. The biological results are discussed in the light of a recently proposed pharmacophore model and compared, by molecular modeling studies, with those obtained from effective BzR ligands.
The Theatre of the French Revolution (1967)

Other| December 01 1967 The Theatre of the French Revolution Marvin Carlson. Ithaca: Cornell University press, 1966. xii + 328 pp. $10.00. Marian Walter Marian Walter Search for other works by this author on: This Site Google Modern Language Quarterly (1967) 28 (4): 500–501. https://doi.org/10.1215/00267929-28-4-500 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Marian Walter; The Theatre of the French Revolution. Modern Language Quarterly 1 December 1967; 28 (4): 500–501. doi: https://doi.org/10.1215/00267929-28-4-500 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter Books & JournalsAll JournalsModern Language Quarterly Search Advanced Search The text of this article is only available as a PDF. Copyright © 1967 by Duke University Press1967 Article PDF first page preview Close Modal Issue Section: Reviews You do not currently have access to this content.
Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism (2023)

Mutations in GBA1, the gene encoding the lysosomal enzyme β-glucocerebrosidase (GCase), which cause Gaucher's disease, are the most frequent genetic risk factor for Parkinson's disease (PD). Here, we employ global proteomic and single-cell genomic approaches in stable cell lines as well as induced pluripotent stem cell (iPSC)-derived neurons and midbrain organoids to dissect the mechanisms underlying GCase-related neurodegeneration. We demonstrate that GCase can be imported from the cytosol into the mitochondria via recognition of internal mitochondrial targeting sequence-like signals. In mitochondria, GCase promotes the maintenance of mitochondrial complex I (CI) integrity and function. Furthermore, GCase interacts with the mitochondrial quality control proteins HSP60 and LONP1. Disease-associated mutations impair CI stability and function and enhance the interaction with the mitochondrial quality control machinery. These findings reveal a mitochondrial role of GCase and suggest that defective CI activity and energy metabolism may drive the pathogenesis of GCase-linked neurodegeneration.
Cobalt-Catalyzed Alkyne−Nitrile Cyclotrimerization To Form Pyridines in Aqueous Solution (2000)

A new, water-soluble cobalt(I) catalyst has been used in the aqueous, chemospecific, cyclotrimerization of one nitrile with two alkynes for the synthesis of highly functionalized pyridines. Several different functional groups are well incorporated in this transformation, including unprotected alcohols, ketones, and amines. Double isotopic crossover data, as well as nitrile dependence on the rate of product formation, suggest associative rate-determining coordination of the nitrile.
Sodium channel Na v 1.8 (2016)

The NaV1.8 sodium channel, encoded by gene SCN10A, was initially termed sensory neuron-specific (SNS) due to prominent expression in primary sensory neurons including dorsal root ganglion (DRG) neurons. Early studies on rodent NaV1.8 demonstrated depolarized voltage dependence of channel inactivation, a slow rate of inactivation, and rapid recovery from inactivation. As a result of these biophysical properties, NaV1.8 supports repetitive firing in response to sustained depolarization. This article reviews recent studies that reveal multiple links of NaV1.8 to human disease: (1) It has recently been shown that functional attributes that distinguish NaV1.8 from other sodium channel subtypes are exaggerated in human NaV1.8; its influence on neuronal activity is thus greater than previously thought. (2) Gain-of-function mutations of NaV1.8 that produce DRG neuron hyperexcitability have been found in 3% of patients with painful neuropathy, establishing a role in pathogenesis. (3) NaV1.8 is ectopically expressed within Purkinje neurons in multiple sclerosis (MS), where it perturbs electrical activity. Recent evidence indicates that variants of SCN10A predict the degree of cerebellar dysfunction in MS. (4) Emerging evidence has linked SCN10A variants to disorders of cardiac rhythm, via mechanisms that may include an effect on cardiac innervation. Involvement of NaV1.8 in neurologic disease may have therapeutic implications. NaV1.8-specific blocking agents, under development, ameliorate pain and attenuate MS-like deficits in animal models. Recent studies suggest that pharmacogenomics may permit the matching of specific channel blocking agents to particular patients. The new links of NaV1.8 in human disease raise new questions, but also suggest new therapeutic strategies.
<title>Measurement of multidimensional strain fields using fiber grating sensors for structural monitoring</title> (1999)

For many structural applications it is highly desirable to be able to measure two or more axes of strain at a single point. In many cases one dimensional strain measurements may be insufficient to fully characterize events or lead to erroneous predictions. This paper will provide an overview of the use of multi-axis fiber grating strain sensors to perform structural diagnostics. Examples of usage of multi-axis fiber grating strain sensors in a smart bearing cell for damage assessment of bridges and for adhesive joints associated with aircraft will be given as illustrations of these methods.
First-line trifluridine/tipiracil + bevacizumab in patients with unresectable metastatic colorectal cancer: final survival analysis in the TASCO1 study (2022)

NCT02743221 (clinicaltrials.gov).
Thermoacoustics of traveling waves: Theoretical analysis for an inviscid ideal gas (1993)

Standard thermoacoustic sources and refrigerators have the stack placed near one end in a standing wave tube. This selection of the stack position optimizes the thermoacoustic effect. For certain applications, however, the effect of a thermoacoustic stack on a traveling wave is of primary interest. Equations governing wave propagation through a stack analogous to the short stack approximation of standing wave thermoacoustics have been derived for an ideal gas. When the wave propagates in the direction of increasing temperature, the wave is amplified by an amount dependent upon the temperature gradient. Waves propagating in the opposite direction are attenuated. Counterpropagating waves in a standing wave tube encounter both. In this case, the results reduce to those developed earlier by Swift [J. Acoust. Soc. Am. 84, 1145–1180 (1988)] and others.
Analytical Derivation of Downlink Data Rate Distribution for 5G HetNets with Cell-Edge Located Small Cells (2016)

In HetNets, time/frequency resources should be partitioned intelligently in order to minimize the interference among the users. In this paper, the probability distributions of per user downlink Data Rate, Spectral Efficiency (SE) and Energy Efficiency (EE) are analytically derived for a HetNet model with cell-edge located small cells. The high accuracy of analytically derived CDFs have been verified by the distributions obtained via simulations. CDF expressions have then been employed in order to optimize Key Parameter Indicators (KPI) which are selected here as $10^{th}$ percentile downlink user Data Rate ($R_{10}$), Spectral Efficiency ($SE_{10}$) and Energy Efficiency ($EE_{10}$). In addition to optimizing KPIs separately, employing the analytically derived distributions, we have also investigated the variation of the KPIs with respect to each other. The results have shown that the resource allocation parameter values maximizing $R_{10}$ is very close to the values that maximize $SE_{10}$. However, the values that are optimal for $SE_{10}$ and $R_{10}$, are not optimal for $EE_{10}$, which demonstrates the EE and SE trade-off in HetNets. We have also proposed a metric, $θ$, aiming to jointly optimize SE and EE. The results have shown the value of resource sharing parameter optimizing $θ$ is closer to the value that maximizes SE. This result shows that SE is more critical in SE-EE trade-off.
Angular Dependent Torque Measurements on CeCoIn$_5$ Single Crystals (2006)

Angular dependent torque measurements were performed on single crystals of CeCoIn$_5$, a heavy fermion superconductor ($T_{c0}$ = 2.3 K), in the temperature, $T$, range 1.9 K $\leq T \leq $ 20 K and magnetic fields $H$ up to 14 T. A large paramagnetic effect is found in the normal state. Torque measurements in the mixed state were also performed. The torque curves show sharp hysteresis peaks at $θ= 90^{o}$ ($θ$ is the angle between $H$ and the $c-$axis of the crystal), a result of intrinsic pinning of vortices. The anisotropy $γ\equiv \sqrt{m_{c}/m_{a}}$ in the mixed state was determined from the reversible part of the vortex contribution to the torque signal using Kogan's model [Phys. Rev. B \textbf{38}, 7049 (1988)]. The anisotropy $γ$ decreases with increasing magnetic field and temperature. The fact that $γ$ is not a constant points towards a multiband scenario in this heavy fermion material.
Photochromic Dynamics of Salicylidene Aniline in Solid State by Using Femtosecond Transient Absorption Spectroscopy (2005)

ABSTRACT This paper reports the dynamics of the photochromic reaction of crystalline N-(3,5-di-tert-butylsalicyliden)-4-aminopyridine which can be applied for nonlinear optical photoswitches. The transient absorption spectra of the microcrystalline powder were measured by femtosecond diffuse reflectance spectroscopy and compared with those in ethanol solution. Similar photochromic reaction occurs in solid state and in solution, however some intermediate species were observed before the long lived photoproduct in solid state probably due to steric hindrance in the crystalline state. Keywords: excited state dynamicsnonlinear opticsorganic crystalphotochromic reactionsalicylidene anilinesecond harmonic generationtime-resolved diffuse reflectance spectroscopy
Atomic layer etching of silicon by using a low-angle forward reflected ar neutral beam (2006)

Summary form only given. Atomic layer etching (ALET) can be an indispensable method in the fabrication of future devices such as nano-scale devices, quantum devices et al., because current etch technology utilizing reactive ion etching does not have precise etch rate controllability and tends to damage the surface of the devices physically and electrically due to the use of energetic reactive ions to achieve vertical etch profiles. Therefore, many studies on ALET of Si have been reported in recent years to develop a technique to etch materials layer-by-layer. But, these previous methods may show charging due to the charged particles such as positive ions and photons generated in the plasma. Therefore, in this study, the ALET of Si was carried out for the first time using an Ar neutral beam instead of the Ar <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> ion beam to avoid charge-related damage during the desorption of halide and its ALET characteristics of Si by Cl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> were investigated. Especially, the ALET of Si having different orientation of (100) and (111) were investigated to understand the silicon etch rate per cycle. Also, the study of ALET mechanisms, variation of surface roughness has been investigated. By supplying Cl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and Ar neutrals higher than critical doses, the constant etch rate of a monolayer per cycle (1.36 and 1.57 Aring/cycle for Si (100) and Si (111), respectively) and the lowest surface roughness of 1.45 Aring close to the reference sample could be obtained regardless of Cl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> pressure and Ar neutral beam irradiation time. The step height divided by the total number of ALET cycles yielded the etch rate per cycle. An atomic force microscope (AFM) was used to measure the surface roughness. Also, a scanning electron microscope (SEM) was used to observe as-etched Si profiles
Direct isolation of genes encoded within a homogeneously staining region by chromosome microdissection. (1994)

Identification of genes involved in recurring chromosome rearrangements has provided significant insight into the molecular basis of malignancy. We describe here a strategy combining chromosome microdissection and hybrid selection for the direct isolation of chromosome region-specific genes. We modeled this strategy by using sequences recovered from the microdissection of a homogeneously staining region to allow isolation of genes that were overexpressed and present at high copy number within the homogeneously staining region, including the direct isolation of two genes encoded within a 12q homogeneously staining region found in the osteosarcoma cell line OsA-CL. Although first applied to amplified genes, this strategy should be applicable to the isolation of cDNAs from any chromosomal region.
Preparation of Monoclonal Antibodies to Chick Neural Retina-Cell-Surface Antigens (1979)

Conference Article| October 01 1979 Preparation of Monoclonal Antibodies to Chick Neural Retina-Cell-Surface Antigens FRANK S. WALSH; FRANK S. WALSH *Muscular Dystrophy Research Laboratories, Institute of Neurology, The National Hospital, Queen Square, London, WC1N 3BG, U.K. Search for other works by this author on: This Site PubMed Google Scholar GEORGE S. EISENBARTH GEORGE S. EISENBARTH †Department of Medicine, Duke University Medical Center, Durham, N.C. 27710, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1979) 7 (5): 1016–1018. https://doi.org/10.1042/bst0071016 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation FRANK S. WALSH, GEORGE S. EISENBARTH; Preparation of Monoclonal Antibodies to Chick Neural Retina-Cell-Surface Antigens. Biochem Soc Trans 1 October 1979; 7 (5): 1016–1018. doi: https://doi.org/10.1042/bst0071016 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1979 Biochemical Society1979 Article PDF first page preview Close Modal You do not currently have access to this content.
NINE CASES OF MALE BREAST CANCER WITH REFERENCE TO LITERATURE (1989)

Male breast cancer is an uncommon disease and its prognosis is reported to be worse than that of the females. Male breast cancer is an uncommon disease and its prognosis is reported to be worse than that of the females. age was 63.3±15.0 years and the duration between first symptom and treatment was 3.8±4.6 months. The most presenting symptom was a breast lump. Preoperatively, all cases were classified into stage I or II and 8 patients underwent radical mastectomy (standard radical mastectomy in 4 cases, Patey's operation in 2 and Auchincloss' operation in 2) and only lumpectomy was performed in one. Histopathologically, 4 of 7 patients had axillary lymph nodes with positive metastasis. Adjuvant chemotherapy was performed in 6 cases and no adjuvant endocrinotherapy was performed. Consequently, there were 4 cases with recurrence, two of which had local recurrence and the remainings had pulmonary metastasis. As the therapy for pulmonary metastasis, although a variety of chemotherapy and endocrinotherapy was performed, they did not yield complete remission. However, endocrinotherapy such as orchiectomy or tamoxifen regimen seemed to be effective, compared with chemotherapy, because they had minimal responses. Therefore in male breast cancer, endocrinotherapy, especially tamoxifen, should be recommended in the treatment of metastatic disease, as well as for an adjuvant use.
Aneurysm flow dynamics: alterations of slipstream flow for neuroendovascular treatment with liquid embolic agents. (2004)

Knowledge of aneurysm flow dynamics and the changes incurred after endovascular parent vessel flow alteration provides a basis for safer aneurysm obliteration by using a liquid embolic agent with a neurointerventional technique.
ChemInform Abstract: A Series of Aluminum Tungsten Oxides Crystallizing in a New ReO3‐Related Structure Type. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Structure and complete nucleotide sequence of the chicken alpha-smooth muscle (aortic) actin gene. An actin gene which produces multiple messenger RNAs. (1986)

The alpha-smooth muscle (aortic) actin gene is a distinct member of the actin multigene family which is expressed in vascular smooth muscle cells. We have determined the complete nucleotide sequence of 11 kilobase pairs of genomic DNA encoding the chicken alpha-smooth muscle actin gene. This single copy gene specifies a protein identical in sequence to the major alpha-actin from bovine aorta. The protein-coding sequences are interrupted by seven introns which are at codons specifying amino acid residues 41/42, 84/85, 121/122, 150, 204, 267, and 327/328. An eighth intron was found in the mRNA 5' untranslated region. The 5' flanking sequences contain elements which are conserved in other chicken muscle actin genes. Additional sequences at the 5' end of the gene may be conserved in at least one human actin gene. We have identified at least four messenger RNAs ranging in size from approximately 1370 to 2700 nucleotides (excluding poly(A) tails) which are transcribed from the alpha-smooth muscle actin gene. These RNAs differ in the length of their 3' untranslated regions, probably as a result of the utilization of alternative polyadenylation signals. This is the first report of an actin gene with multiple mRNA transcripts.
Oral and dental management related to radiation therapy for head and neck cancer. (2003)

The clinical management of squamous cell carcinoma of the head and neck causes oral sequelae that can compromise patients' quality of life and necessitate abandonment or reduction of optimal therapeutic regimens, which in turn reduces the odds of long-term survival. Such sequelae can be prevented or at least better managed if dental and medical health care providers work together. It is therefore essential that dentists have an understanding of cancer therapy and a sound working knowledge of the prevention and management options for the oral sequelae of cancer treatment. This paper offers the dental team an overview of the consequences associated with radiotherapy, as well as a systematic overview of preventing or managing acute and chronic conditions before and during radiotherapy. In addition, it reviews considerations for continued treatment needs during the patient"s lifetime.
Sorafenib plus tegafur&ndash;uracil (UFT) versus sorafenib as first line systemic treatment for patients with advanced stage HCC: a Phase II trial (ESLC01 study) (2018)

In patients with advanced HCC, adding UFT to sorafenib is feasible, but it did not improve efficacy outcome over sorafenib monotherapy.
Two-Detector, 512-Element High Purity Germanium Camera Prototype (1978)

A gamma-ray camera consisting of two 3.2×3.2×1-cm3 HPGe detectors has been assembled. Shallow orthogonal grooves define 512 2×2-mm2 elements. Square hole collimators have been fabricated with design parameters that exploit the unique characteristics of the detector. Intrinsic spatial resolution is a square function with 2-mm width, and energy resolution is approximately 2.5% FWHM at 140 keV. Evidently superior images are obtained when this instrument is compared to state-of-the-art scintillation cameras.
Impact of fat substitutes on fat intake (1996)

Dietary fat is the number one nutrition concern of Americans. In response to rising consumer demand for reduced-fat foods, the food industry has developed a multitude of nonfat, lowfat, and reduced-fat versions of regular food products. To generate reduced-fat or fat-free products that have the same organoleptic characteristics of the regular fat version, food manufacturers frequently employ fat substitutes in the formulation of these foods. Fat substitutes are made from either carbohydrate, protein, or fat, or a combination of these components. Researchers have questioned the impact of fat substitutes on both fat and caloric intake. The majority of research studies in which fat substitutes were either covertly or overtly substituted for dietary fat indicate that in short-term, carefully-controlled conditions, fat substitutes can decrease both dietary fat intake and percentage of calorie intake from fat. However, individuals compensate for the caloric deficit created by the fat substitutes by increasing their consumption of other macronutrients, primarily carbohydrate. The long-term effect of fat substitutes on the fat intake of free-living individuals and weight control are unknown. People tend to eat more of a food when they know that food is reduced in fat. Fat substitutes should not be considered a substitute for sound nutrition education and a healthy lifestyle which includes regular exercise.
ChemInform Abstract: Synthesis of 1,3‐Dioxin‐4‐ones and Their Use in Synthesis. Part 21. Cycloadditions in Syntheses. Part 45. Intramolecular Photo(2 + 2)cycloaddition Reactions of Chiral Spirocyclic Dioxinones Having ω‐Alkenyl Groups at 3‐Position. (1990)

Abstract Alkylation of the acetoacetate (I) with the bromides (II) and subsequent acetalization with cyclohexanone (III) or L‐menthone (IX) yield the dioxinones (IV) or (X).
Machine-adaptable dynamic binary translation (2000)

Dynamic binary translation is the process of translating and optimizing executable code for one machine to another at runtime, while the program is “executing” on the target machine.