gebhart/patrepeval huggingface dataset:
A surveillance system of Invasive Pneumococcal Disease in North-Eastern Italy. (2017)

In the Veneto Region, the surveillance system has allowed to describe the detailed epidemiological profile of invasive pneumococcal disease, pointing out that the most circulating pneumococcal serotypes were those contained in the PCV13 vaccine.
Combined TRAF6 Targeting and Proteasome Blockade Has Anti-myeloma and Anti-Bone Resorptive Effects (2017)

TNF receptor-associated factor 6 (TRAF6) has been implicated in polyubiquitin-mediated IL1R/TLR signaling through activation of <i>IκB</i> kinase (IKK) to regulate the NF-κB and JNK signaling pathways. Here, TRAF6 protein was determined to be overexpressed in bone marrow mononuclear cells (BMMC) from patients with multiple myeloma. <i>TRAF6</i> expression in BMMCs from patients with progressive disease is significantly elevated as compared with individuals in complete remission, with monoclonal gammopathy of undetermined significance, or healthy subjects. Furthermore, TRAF6 dominant-negative (TRAF6dn) peptides were constructed which specifically reduced TRAF6 signaling and activation of IKK. TRAF6 not only reduced cellular growth but also increased the apoptosis of multiple myeloma tumor cells in a concentration-dependent fashion. Because TRAF6 activates IKK through polyubiquitination, independent of its proteasome activity, a TRAF6dn peptide was combined with the proteasome inhibitors bortezomib or carfilzomib to treat multiple myeloma. Importantly, targeting of TRAF6 in the presence of proteasome inhibition enhanced anti-multiple myeloma effects and also decreased TLR/TRAF6/NF-κB-related signaling. Finally, TRAF6dn dose dependently inhibited osteoclast cell formation from CD14<sup>+</sup> monocytes, induced with <i>RANKL</i> and <i>mCSF</i>, and markedly reduced bone resorption in dentin pits. In all, these data demonstrate that blocking TRAF6 signaling has anti-multiple myeloma effects and reduces bone loss.<b>Implications:</b> The ability to target TRAF6 signaling and associated pathways in multiple myeloma suggests a promising new therapeutic approach. <i>Mol Cancer Res; 15(5); 598-609. ©2017 AACR</i>.
A detailed characterization of a high pressure experimental apparatus for flame dynamic studies (2017)

This work is partly funded by the Center of Competitive Funding from King Abdullah University of Science and Technology (Grant number 1975).
Evaluation of Damping Property of Aluminum-Alloyed Cast Iron by Several Methods (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Photocatalytic Activity of Pulsed Laser Deposited TiO2 Thin Films (2007)

Nanostructured TiO2 thin films were prepared by pulsed laser deposition (PLD) on indium doped tin oxide (ITO) substrates. Results from X-ray photoelectron spectroscopy (XPS) show that Ti 2p core level peaks shift toward the lower binding energy with decrease in the buffer gas pressure (O2:Ar = 1:1). This suggests that oxygen vacancies are created under insufficient oxygen conditions. Anatase to rutile ratio is also found to be system pressure dependent. Under deposition pressure of 750 mTorr only anatase phase was observed even at 1073 K substrate temperature which is much higher that the bulk anatase to rutile phase transformation temperature. The deposited TiO2 thin films were fabricated as photoanodes for photoelectrochemical (PEC) studies. PEC measurements on TiO2 photoanodes show that the flatband potential (Vfb) increases by 0.088 eV on absolute vacuum energy scale (AVS) with decrease in the deposition pressure, from 750 to 250 mTorr at 873K. The highest incident photon to current conversion efficiency [IPCE(lambda)] of 2.5 to 6 % was obtained from the thin films prepared at substrate temperature of 873K. Combining the results from XPS and PEC studies, we conclude that the deposition pressure affects the concentration of the oxygen vacancies which changes the electronic structure of the TiO2. With reference to photoelectrochemical catalytic performance, our results suggest that it is possible to adjust the Fermi energy level and structure of TiO2 thin films by controlling the buffer gas pressure and temperature to align the energy of the flatband potential (Vfb) with respect to specific redox species in the electrolyte.
Chemical study of Phylloxylon xylophylloides Baker and assessment of its anti-hyperglycaemic activity in Glucose-loaded Normal Rabbits (2020)

The present study was carried out to investigate the chemical constituents and the anti-hyperglycaemic activity of Phylloxylon xylophylloides Baker. The separations of the chemical compounds of hexane and ethyl acetate extracts on the leaves were carried out using different chromatographic techniques and their structures were elucidated by spectroscopic method including nuclear magnetic resonance. Seven compounds were identified during this investigation. There are trioleine 1, palmitic acid 2, β-sitosterol 3, stigmasterol 4, taraxerol 5, α-amyrine 6, betulinic acid 7. The anti-hyperglycaemic activity of ethanolic extracts of leaves and stem bark of Phylloxylon xylophylloides Baker was assessed in glucose-loaded normal rabbits. At a dose of 100, 250 and 500 mg / kg, these ethanolic extracts significantly (p< 0.05) lowered the rise in blood glucose with respect to the control group. These results are in accordance with the folk use of this plant.
Growth and Properties of Hybrid Organic‐Inorganic Metalcone Films Using Molecular Layer Deposition Techniques (2012)

Abstract Molecular layer deposition (MLD) is a useful technique for fabricating hybrid organic‐inorganic thin films. MLD allows for the growth of ultrathin and conformal films using sequential, self‐limiting reactions. This article focuses on the MLD of hybrid organic‐inorganic films grown using metal precursors and various organic alcohols that yield metal alkoxide films. This family of metal alkoxides can be described as “metalcones”. Many metalcones are possible, such as the “alucones” and “zincones” based on the reaction of trimethylaluminum and diethylzinc, respectively, with various organic diols such as ethylene glycol. Alloys of the various metalcones with their parent metal oxide atomic layer deposition (ALD) films can also be fabricated that have an organic‐inorganic composition that can be adjusted by controlling the relative number of ALD and MLD cycles. These metalcone alloys have tunable chemical, optical, mechanical, and electrical properties that may be useful for designing various functional films. The metalcone hybrid organic‐inorganic materials offer a new tool set for engineering thin film properties.
Authenticated secure bio-metric based access to the bank safety lockers (2014)

This paper focuses on providing a secure, authentic and user-friendly mechanism for both the customer's of the bank holding a locker and the branch head's involvement in all the operations pertaining to the safety lockers. The primary aim of this paper is to provide a solution towards a complete biometric based authentication mechanism for operating the safety lockers. This system rests on improving the current fact that all the lockers that operates currently operates only with the help of two different keys - one the branch head's key and other the user key. Improvement towards the current model that relies heavily on the key of the user is proposed which helps in the functioning of the locker with bio-metric and secret code (password). The main features that are proposed in the new mechanism is the two level authentication - one by the branch head and one by the user for their identities, secure individual authentication with their bio-metrics and the access only to the concerned individuals for their safety lockers. The branch head responsible for the operation of the safety deposits is assigned in a daily basis by the central regional office of that particular bank.
CHARACTERIZATION OF AN OFF-BODY CHANNEL AT 2.45 GHZ IN AN UNDERGROUND MINE ENVIRONMENT (2015)

Underground mines are challenging environments for off-body wireless communication, since the signal propagation is majorly affected by small scale and large scale fading. The use of multiple antennas at the transmitter and the receiver sides is a known technique to combat fading and enhance capacity. In this paper, the channel parameters of a 2 2 Multiple-Input Multiple-Output (MIMO) off-body system are investigated in an underground gold mine and compared to the Single-Input Single-Output (SISO) system parameters. Measurement campaigns were conducted using monopole antennas at a center frequency of 2.45 GHz for both Line Of Sight (LOS) and None Line of Sight (NLOS) scenarios. The measured frequency responses are converted into impulse responses through an Inverse Fourier Transform (IFT). The results show that for a constant transmitted power, the path loss exponents at NLOS are smaller than their counterpart values at LOS. The channel capacity values decrease as the propagation distance increases and when the link is obstructed at NLOS. The RMS delay spread is generally increasing with distance for both LOS and NLOS situations. When a fixed Signal-to-Noise Ratio (SNR) is assumed, MIMO topologies improved the SISO capacity by roughly 8 bps/Hz. The channel characterization results demonstrate that the MIMO configurations provided a remarkable improvement in terms of capacity, coherence bandwidth, and time delay spread compared to the SISO topologies.
MicroRNA delivery through nanoparticles (2019)

MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to their central role in the etiology of major diseases. On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration. A fresh perspective is presented on the design and characterization of nanocarriers to accelerate translation from basic research to clinical application of miRNA-nanoparticles. Main challenges in the engineering of miRNA-loaded nanoparticles are discussed, and key application examples are highlighted to underline their therapeutic potential for effective and personalized medicine.
Molecular aspects of the teratogenesis of rubella virus (2019)

Rubella or German measles is an infection caused by rubella virus (RV). Infection of children and adults is usually characterized by a mild exanthematous febrile illness. However, RV is a major cause of birth defects and fetal death following infection in pregnant women. RV is a teratogen and is a major cause of public health concern as there are more than 100,000 cases of congenital rubella syndrome (CRS) estimated to occur every year. Several lines of evidence in the field of molecular biology of RV have provided deeper insights into the teratogenesis process. The damage to the growing fetus in infected mothers is multifactorial, arising from a combination of cellular damage, as well as its effect on the dividing cells. This review focuses on the findings in the molecular biology of RV, with special emphasis on the mitochondrial, cytoskeleton and the gene expression changes. Further, the review addresses in detail, the role of apoptosis in the teratogenesis process.
Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis (1999)

Colonic enterocytes, like many epithelial cells in vivo, are polarized with functionally distinct apical and basolateral membrane domains. The aims of this study were to characterize the endogenous epidermal growth factor (EGF)-like ligands expressed in two polarizing colon cancer cell lines, HCA-7 Colony 29 (HCA-7) and Caco-2, and to examine the effects of cell polarity on EGF receptor-mediated mitogenesis. HCA-7 and Caco-2 cells were grown on plastic, or as a polarized monolayer on Transwell filters. Cell proliferation was measured by 3H-thymidine incorporation and EGF receptor (EGFR) binding was assessed by Scatchard analysis. EGFR ligand expression was determined by Northern blot analysis, reverse transcription polymerase chain reaction, metabolic labelling and confocal microscopy. We found that amphiregulin (AR) was the most abundant EGFR ligand expressed in HCA-7 and Caco-2 cells. AR was localized to the basolateral surface and detected in basolateral-conditioned medium. Basolateral administration of neutralizing AR antibodies significantly reduced basal DNA replication. A single class of high-affinity EGFRs was detected in the basolateral compartment, whereas the apical compartment of polarized cells, and cells cultured on plastic, displayed two classes of receptor affinity. Basolateral administration of transforming growth factor alpha (TGF-alpha) or an EGFR neutralizing antibody also resulted in a dose-dependent stimulation or attenuation, respectively, of DNA replication. However, no mitogenic response was observed when these agents were added to the apical compartment or to confluent cells cultured on plastic. We conclude that amphiregulin acts as an autocrine growth factor in HCA-7 and Caco-2 cells, and EGFR ligand-induced proliferation is influenced by cellular polarity.
Synthesis, Physicochemical Characterization, and Catalytic Evaluation of Fe3+-Containing SSZ-70 Zeolite (2022)

Whereas one-dimensional, 10-membered ring zeolites are typically used for hydroisomerization, Fe3+-containing SSZ-70 (Fe-SSZ-70) shows remarkable isomerization selectivity for a zeolite containing 12- and partially blocked 14-membered rings, in addition to 10-membered rings. Fe-SSZ-70 was compared to Al3+-containing SSZ-70 (Al-SSZ-70) in constraint index and n-decane hydrocracking tests. Fe-SSZ-70 exhibited a 74% total isomer yield (64% yield of monobranched isomers and 10% cracking yield) at 85% conversion compared to 49% total isomer yield (41% yield of monobranched isomers and 36% cracking yield) for Al-SSZ-70 at the same conversion. The selectivity to isomerization is attributed to the weaker acid strength of Fe-SSZ-70 over Al-SSZ-70. Fe-SSZ-70 was directly synthesized with Fe3+ isomorphously substituted in tetrahedral positions. The coordination environment of the Fe3+ was characterized using Mössbauer, electron paramagnetic resonance, and diffuse reflectance UV–vis spectroscopies. The physicochemical properties were further probed with inductively coupled plasma atomic emission spectroscopy, temperature-programmed desorption of isopropylamine, and nitrogen adsorption–desorption. The Fe3+ was tetrahedrally coordinated in the as-made materials and became partially octahedrally coordinated upon calcination; enough Fe3+ remained in the framework after calcination for Fe-SSZ-70 to remain catalytically active.
Barriers to AEEs: Interoperability of Systems and Tools (2000)

Space 2000 Conference, Long Beach.
Progression of hormone-dependent adenocarcinoma cells to hormone-independent spindle carcinoma cells in vitro in a clonal spontaneous rat mammary tumor cell line. (1995)

A hormone-dependent, clonal carcinoma cell line, designated RM22-F5, was derived from a malignant mammary mixed tumor spontaneously arising in an outbred old female Wistar rat. These cells expressed keratin and desmosomal protein and formed epithelial monolayers in a growth factor and hormone-supplemented medium (LHC-8) containing 10% fetal bovine serum (E-type cells). Cells subcultured for 6 to 8 passages in RPMI 1640 medium containing 10% fetal bovine serum without supplements appeared to be fibroblastic and expressed vimentin (F-type cells). The shift to a fibroblast-like morphology was associated with a more malignant phenotype which included rapid, hormone-independent growth and invasive sarcoma-like character in nude mice. F-type cells were no longer able to express their original epithelial phenotype in LHC-8 medium. Cytogenetic analysis revealed that both E- and F-type cells had essentially the same karyotype. Analysis of PCR-amplified DNA further demonstrated a point mutation of the H-ras-1 gene at codon 12 and loss of the normal H-ras-1 allele in both cell types. Genetic tagging of E-type cells with the neomycin-resistance gene resulted in the generation of F-type cells with neomycin resistance in RPMI 1640 medium, suggesting that F-type cells are a malignant variant of E-type cells arising during in vitro culture. Somatic cell fusion between E- and F-type cells revealed that with most hybrid clones tested, the fibroblast-like phenotype was greatly suppressed. These results suggest that an irreversible phenotypic transition, representative of tumor progression from hormone-dependent adenocarcinoma to more malignant hormone-independent spindle carcinoma cells, is a recessive event and may involve loss of a suppressor function.
Paging Strategy with Dynamic Wake-Up Period in Cellular Communication Systems (2006)

We propose that each mobile terminal should have the dynamic wake-up period for monitoring the paging slot in cellular communication systems. The value of wake-up period for a mobile terminal is determined depending on its movement and call behavior. The numerical results show that the proposed strategy significantly reduces the number of wake-ups for monitoring the paging slot, resulting in less battery power consumption of mobile terminal compared to the traditional strategy.
The higher the better? Think twice! (2014)

As research interest in the Internet of Things continue to grow, concerns are raised regarding potential limitations of the current body of knowledge on performance engineering for wireless links. Best practices in this thematic area have insofar largely been focused on human-to-human communications (e.g., wide area cellular wireless networks) and traffic patterns emerging from human actions (e.g., asymmetric bandwidth between the uplink and downlink traffic directions) in urban areas. As a result, studies of the propagation profile that would properly characterize the deployment of wireless technologies (e.g., sensor networks) in rural areas and for specific applications of machine-to-machine (M2M) communications are not sufficiently developed in the literature. To address this shortcoming, we collect and study RSSI measurements as a function of base station antenna height and at a certain distance and transmitting antenna height, under a rural setting. The measurements collected from our testbed instrumentation seem to follow closely the theoretical two-ray model. It is therefore shown here that whenever a second ray has impact on propagation characteristics there is always an optimum and minimum base station antenna height. A method for defining those heights is presented in this paper, which further allows performance optimisation of a wireless sensor network.
Photochromism of metal–organic frameworks based on carbazole-dicarboxylic acid and bipyridine: sensing adjustment by controlling strut-to-strut energy transfer (2020)

In this paper, two energy-transfer photochromic metal-organic frameworks (MOFs) {[Zn(L)<sub>0.5</sub>(bpy)]·H<sub>2</sub>O·DMF}<sub>n</sub> (1) and {[Zn(L)<sub>0.5</sub>(bpe)]·2H<sub>2</sub>O·DMF}<sub>n</sub> (2) (H<sub>4</sub>L = 9,9'-(1,4-phenylenebis(methylene))bis(9H-carbazole-3,6-dicarboxylic acid), bpy = 4,4'-bipyridine, bpe = 4,4'-vinylenedipyridine) were designed and synthesized. Both 1 and 2 showed similar pillared-paddle wheel type frameworks with bpy and bpe as the chromophore, respectively, and L<sup>4-</sup> as the antenna-type light harvester, yielding strut-to-strut energy transfer (antenna behavior) within the well-ordered structures. Among them, 1 displayed excellent energy-transfer photochromic behavior under UV light accompanied by color transformation from colorless to purple. In addition, the photochromic behavior of 1 has obvious, fast, controllable and reversible characteristics. On the other hand, 2 showed a different energy-transfer photochromic behavior in the aspects of color changing, gamut, and sensitivity. The variation has been ascribed to the substitution of chromophore bpy in 1 with bpe in 2, which influences the efficiency of energy transfer within the MOFs. Therefore, with the structural diversity and tunability of MOFs, the sensitivity, color, and gamut of energy-transfer of the photochromic MOFs can be tuned by the appropriate choice of the constitutions of MOFs. This work will provide useful guidance for developing novel energy-transfer photochromic MOF materials.
Healthcare resource utilization (HCRU) and costs for patients (pts) with metastatic renal cell carcinoma (mRCC) receiving first-line (LOT1) pembrolizumab plus axitinib (P+A) or ipilimumab plus nivolumab (I+N). (2022)

4528 Background: Approval of immuno-oncology (IO) agents have changed treatment paradigm for mRCC pts. While IO-based therapies have demonstrated improved survival, these can be associated with considerable HCRU and costs necessitating their examination in real-world practice. Methods: This retrospective claims analyses utilizing Optum Research Database included adult pts with mRCC diagnosis from July-2017 to Aug-2020 and received P+A or I+N as LOT1 from Jan-2018 to May-2020 (first claim=index date). All eligible pts required continuous enrollment for minimum of 6-months prior and 3-months post the index date unless death occurred. All-cause HCRU counts, and associated costs were examined during the first 90 days (LOT1-90) and entire LOT1 duration and reported as overall and per-pt-per-month (PPPM) estimates. Results: The study identified 507 pts (P+A=126, I+N=381). Average age of the entire cohort was 67 years, 71% were male, mean NCI Charlson score was 2.4, and lung (55%) and bone (33%) were the most common metastatic sites. Mean (SD) distance from mRCC diagnosis to index date was 97 (172) days. Pts with P+A and I+N had similar baseline characteristics. Total % of pts with ambulatory visits was similar for P+A and I+N for LOT1-90 and entire LOT1 (99.2 vs. 100.0%, p=0.082 for both). During LOT1-90, we observed a lower % of pts on P+A with ER visits and inpatient (IP) stay compared to I+N (34 vs. 48, p=0.008; 19 vs. 38, p&lt;0.001, respectively). We also observed a shorter mean (SD) IP stay for P+A vs. I+N during LOT1-90 (1.9 (6.5) vs. 5.6 (13.24) days, p&lt;0.001). Similarly, P+A had lower mean PPPM ambulatory visits, IP stay, and ICU stay during both LOT1-90 and entire LOT1 (Table). In addition, mean PPPM total (medical + pharmacy) and mean PPPM medical costs were lower for P+A compared to I+N, but mean PPPM pharmacy costs were higher for P+A for both LOT1-90 and entire LOT-1 (Table). Conclusions: This study noted significantly higher HCRU with I+N including higher mean PPPM ambulatory visits, IP stays, and ICU stays compared to P+A. Although, P+A had higher mean PPPM pharmacy costs, the total medical plus pharmacy costs were significantly lower compared to I+N. [Table: see text]
Laminoplasty versus laminectomy with fusion for treating multilevel degenerative cervical myelopathy (2023)

When treating multilevel DCM, LP has similar rates of new or increasing axial neck pain compared to LF. LF was associated with greater hospital costs, length of stay, and complications compared to LP. LP may in fact be a less morbid and more cost-effective alternative to LF for patients without cervical deformity.