gebhart/patrepeval huggingface dataset:
C2v- and C2-Symmetric ansa-Bis(fluorenyl)zirconocene Catalysts: Synthesis and .alpha.-Olefin Polymerization Catalysis (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTC2v- and C2-Symmetric ansa-Bis(fluorenyl)zirconocene Catalysts: Synthesis and .alpha.-Olefin Polymerization CatalysisYou-Xian Chen, Marvin D. Rausch, and James C. W. ChienCite this: Macromolecules 1995, 28, 16, 5399–5404Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/ma00120a001https://doi.org/10.1021/ma00120a001research-articleACS PublicationsRequest reuse permissionsArticle Views241Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Neutrophils in Innate Immunity (2004)

Neutrophils are an important component of innate immunity in the lungs. During bacterial pneumonia, neutrophils are recruited from the capillaries of the pulmonary circulation in the gas-exchanging regions of the lungs. This process requires the coordinated activation of many cells within the lungs, including neutrophils and capillary endothelial cells. Cellular activation during innate immune responses is mediated in part by tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1-initiated signaling through their receptors, activation of nuclear factor kappa B (NF-kappaB) and downstream gene transcription, endothelial cell signaling initiated by neutrophil adherence to intercellular adhesion molecule (ICAM)-1, and binding of leukocyte adhesion molecules to cellular and matrix ligands. These events are essential to effective host defense during pneumonia.
Experimental study of different silicon sensor options for the upgrade of the CMS Outer Tracker (2020)

: During the high-luminosity phase of the LHC (HL-LHC), planned to start in 2027, the accelerator is expected to deliver an instantaneous peak luminosity of up to 7.5 10 34 cm -2 s -1 . A total integrated luminosity of 3000 or even 4000 fb -1 is foreseen to be delivered to the general purpose detectors ATLAS and CMS over a decade, thereby increasing the discovery potential of the LHC experiments significantly. The CMS detector will undergo a major upgrade for the HL-LHC, with entirely new tracking detectors consisting of an Outer Tracker and Inner Tracker. However, the new tracking system will be exposed to a significantly higher radiation than the current tracker, requiring new radiation-hard sensors. CMS initiated an extensive irradiation and measurement campaign starting in 2009 to systematically compare the properties of different silicon materials and design choices for the Outer Tracker sensors. Several test structures and sensors were designed and implemented on 18 different combinations of wafer materials, thicknesses, and production technologies. The devices were electrically characterized before and after irradiation with neutrons, and with protons of different energies, with fluences corresponding to those expected at different radii of the CMS Outer Tracker after 3000 fb -1 . The tests performed include studies with sources, lasers, and beam scans. This paper compares the performance of different options for the HL-LHC silicon sensors with a focus on silicon bulk material and thickness.
Characterizing thalamic and basal ganglia nuclei in medically intractable focal epilepsy by MR fingerprinting (2022)

MRF revealed bilateral tissue-property changes in the normal-appearing thalamus and basal ganglia, with ipsilateral predominance and thalamic preference, suggesting subcortical involvement/impairment in patients with medically intractable focal epilepsy. The individual-level performance of the MRF-based machine-learning models suggests potential opportunities for predicting lateralization.
Étude physiologique de streptomyces pristinaespiralis producteur de pristinamycines : activités enzymatiques du métabolisme central et mesure du Ph intracellulaire (2000)

In the last decade, a new rational strategy for fine optimization of industrial interest metabolites production has been achieved by means of metabolic engineering. This field does not only limits to ponctual genomic manipulations in the producing cells, but requires a deeper insight of their phisiology. In this context, a part of carbohydrate (glucose) metabolism in the pristinamycins producing Streptomyces pristinaespiralis has been investigated during trophophase and idiophase. Specific activities for some enzymes belonging to the central metabolism were assayed during batch cultures and showed a general diminution before the antibiotic being excreted. Another basic physiological parameter is the intracellular pH (pHi), which not only affects enzymatic activities but also provides informations about intracellular metabolism. A novel method for its determination has been developped by means of epifluorescence microscopy combined to image analysis. pHi during batch fermentations undergone severe fluctuations correlated to pristinamycins production and succinate and lactate excretions. Finally all parameters measurements were performed during different dilution rates chemostat. Cyclic productions of pristinamycins were observed due to thepristinamycins repression on their own synthesis. This study aUowed quantification of enzymatio contents for different growth rates of non producing cells and revealed pHi changes of a lesser magnitude.
SLE - hematopoietic stem cell transplantation for systemic lupus erythematosus. (2003)

Hematopoietic stem cell transplantation was first reported for patients with systemic lupus erythematosus in 1997. The procedure has since been performed worldwide including in Europe, in Brazil, and in China. A National Institutes of Health-funded phase III clinical trial of hematopoietic stem cell transplantation for refractory systemic lupus erythematosus is anticipated to begin in 2003. Encouraging responses are raising new hope about the role of adult hematopoietic stem cells in systemic lupus erythematosus.
Analysis of alkaloids in Ipecacuanhae radix and preparations by capillary zone electrophoresis (2003)

Abstract A capillary zone electrophoresis method for quantitation of the alkaloids emetine and cephaeline in Ipecacuanhae radix fluid extract and Ipecac syrup using papaverine as internal standard is described. Baseline separation was achieved within 10 min using a fused silica capillary and a running electrolyte consisting of citric acid (50 mM), disodium hydrogenphosphate (100 mM), and 2.5% methanol (pH 4.4). Regression equations revealed a linear response from 0.05 to 1.9 mg/mL for cephaeline and emetine (correlation coefficients 0.9991–0.9993). The lowest quantitation limits were determined as 0.03 mg/mL for both alkaloids, and the limit of detection was 0.012 mg/mL. The day‐to‐day variations of retention times were &lt; 1.3% for both compounds. Whereas no sample pre‐treatment was necessary for analysis of the fluid extract, SPE had to be applied before CE analysis of the syrup. The recovery rate for emetine in this case was &gt; 99.8%.
Radial Keratotomy-Reply (1983)

<h3>In Reply.</h3> —Our patient was first diagnosed as having keratoconus in 1962. This had advanced to keratoglobus by 1973. Following his right corneal transplant, the patient achieved 6/12 (20/40) visual acuity. Because of problems associated with a high-post keratoplasty astigmatism, central graft edema developed while the patient was wearing his contact lenses. At no time did the patient have evidence of diffuse epithelial pathologic characteristics. In our experience, this would be an example of a patient who would benefit from a relaxing corneal incision. One of us (P.S.B.) has performed 15 such procedures without any substantial effect on the anterior ocular surface. The surgeon in our case report (not one of the authors) was experienced in radial keratotomy at the time he performed the operation. Dr Thornton has stated that the use of a 2.5-mm optical zone is guaranteed to produce glare, flare, and halos. When this procedure was performed
Diversities and the Generalized Circumradius (2021)

The generalized circumradius of a set of points $A \subseteq \mathbb{R}^d$ with respect to a convex body $K$ equals the minimum value of $λ\geq 0$ such that $A$ is contained in a translate of $λK$. Each choice of $K$ gives a different function on the set of bounded subsets of $\mathbb{R}^d$; we characterize which functions can arise in this way. Our characterization draws on the theory of diversities, a recently introduced generalization of metrics from functions on pairs to functions on finite subsets. We additionally investigate functions which arise by restricting the generalised circumradius to a finite subset of $\mathbb{R}^d$. We obtain elegant characterizations in the case that $K$ is a simplex or parallelotope.
Effect of nonuniform doping on electrical transport intrans-(CH)x: Studies of the semiconductor-metal transition (1982)

Owing to the strong dependence of the resistivity on the dopant concentration, nonuniformity across the thickness of a sample leads to an apparent anisotropy in the resistivity (measured parallel to and perpendicular to the plane of the film). Thus the magnitude of the apparent anisotropy (for nonoriented samples) offers a convenient means for quantifying the degree of dopant nonuniformity in trans-${(\mathrm{CH})}_{x}$. This technique is used to evaluate the uniformity achieved in ${[\mathrm{CH}{(\mathrm{As}{\mathrm{F}}_{5})}_{y}]}_{x}$ by conventional vapor-phase doping as compared with the slow-doping technique developed earlier for susceptibility studies. Using samples which have been demonstrated in this manner to be uniform, we reexamine the semiconductor-metal transition. From the transport data, we find that the better the uniformity in the distribution of dopant, the more abrupt is the transition at ${y}_{c}\ensuremath{\simeq}0.002$. A generalized soliton picture, involving delocalized carriers, appears to be implied by the combination of optical, magnetic, and transport data.
Garbarge collection for Prolog based on WAM (1988)

The Warren abstract machine (WAM) has become a generally accepted standard Prolog implementation technique. Garbage collection is an important aspect in the implementation of any Prolog system. A synopsis of the WAM is presented and then marking and compaction algorithms are shown that take advantage of WAM's unique use of the data areas. Marking and compaction are performed on both the heap and the trail; both use pointer reversal techniques, which obviate the need for extra stack space. However, two bits for every pointer on the heap are reserved for the garbage collection algorithm. The algorithm can work on segments of the heap, which may lead to a significant reduction of the total garbage collection time. The time of the algorithms are linear in the size of the areas.
Cryopreservation of Oocytes Retrieved from Ovarian Tissue to Optimize Fertility Preservation in Prepubertal Girls and Women (2020)

Human ovarian tissue cryopreservation (OTC) is increasingly used worldwide to preserve female fertility in prepubertal girls and women at risk of premature ovarian insufficiency (POI) in the context of urgent gonadotoxic treatments or ovarian surgery. Fertility preservation is challenging because there is no consensus regarding patient management, preservation fertility strategies, or even technical laboratory protocols, which implies that each procedure must be adapted to the characteristics of the patient profile and its own risk-benefit ratio. During OTC, mature/immature oocytes can be aspirated directly from large/small antral follicles within ovarian tissue samples and/or be released into culture media from growing follicles during ovarian tissue dissection in prepubertal girls and women. In this manuscript, we present a protocol that combines ovarian tissue freezing with the cryopreservation of mature/immature oocytes retrieved from ovarian tissue samples, improving the reproductive potential of fertility preservation. Appropriate collection, handling, and storage of ovarian tissue and oocytes before, during, and after the cryopreservation will be described. The subsequent use and safety of cryopreserved/thawed ovarian tissue samples and oocytes will also be discussed, as well as the optimal timing for in vitro maturation of immature oocytes. We recommend the systematic use of this protocol in fertility preservation of prepubertal girls and women as it increases the whole reproductive potential of fertility preservation (i.e., oocyte vitrification in addition of OTC) and also improves the safety and use of fertility preservation (i.e., thawing of oocytes versus ovarian graft), maximizing the chance of successful childbirth for the patients at risk of POI.
Design And Performance Of A Modular, Multi‐Purpose Electrochemical Reactor (1983)

A new multipurpose electrochemical reactor, based on the plate and frame principle, has been developed for use in both laboratory research and industrial production. Among its advantages, this ElectroSynCell (ESC) exhibits good mass transfer characteristics due to efficient turbulent promoters. Experimental studies of limiting currents have shown that the specially designed grid promoter gives a more than threefold increase in mass transfer rates. The possible application in small‐scale chlor‐alkali processes has also been investigated. Cost estimates based on the reported experimental results show that the ESC is competitive in this field.
Implementation of the spatial and the temporal cross-ambiguity function for waveguide fields and optical pulses (1999)

On the basis of space-time duality, we propose experimental setups to implement the cross-ambiguity function optically in space and time in one and two dimensions. In space the cross-ambiguity is shown to be related to the coupling efficiency between butt-joined optical waveguides. In time it is related to the spectrogram or the frequency-resolved optical gating techniques for the characterization of optical pulses.
Synthesis of a peptide-universal nucleotide antigen: towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes (2016)

The topoisomerase (topo) I-DNA covalent complex represents an attractive target for developing diagnostic antibodies to measure responsiveness to drugs. We report a new antigen, peptide , and four murine monoclonal antibodies raised against that exhibit excellent specificity for recognition of in comparison to structurally similar peptides by enzyme-linked immunosorbent assays. Although topo I-DNA complex detection was not achieved in cellular samples by these new antibodies, a new strategy for antigen design is reported.
Evolutionary neural networks: a robust approach to software reliability problems (2002)

In this empirical study, from a large data set of software metrics for program modules, thirty distinct partitions into training and validation sets are automatically generated with approximately equal distributions of fault prone and not fault prone modules. Thirty classification models are built for each of the two approaches considered-discriminant analysis and the evolutionary neural network (ENN) approach-and their performances on corresponding data sets are compared. The lower error proportions for ENNs on fault prone, not fault prone, and overall classification were found to be statistically significant. The robustness of ENNs follows from their superior performance on the range of data configurations used. It is suggested that ENNs can be effective in other software reliability problem domains, where they have been largely ignored.
Challenges of Cardiovascular Risk Assessment in the Routine Rheumatology Outpatient Setting: An Observational Study of 110 Rheumatoid Arthritis Patients (2013)

The assessment of CV risk factors is feasible, but labor intensive, during an outpatient rheumatology clinic. This assessment identified modifiable CV risk factors in 30% of the patients. These results suggest that RA patients are not sufficiently assessed and treated for CV risk factors.
SiOx Gas Barrier Coatings on Polymer Substrates:  Morphology and Gas Transport Considerations (1999)

Plasma-enhanced chemical vapor deposition (PECVD) of SiOx thin coatings on polymer surfaces yields tough hybrid materials with the gas barrier properties and transparency of glass. Combination of these properties makes these materials ideally suited for food packaging and biomedical device applications. In this study, we employ a Non-Parametric Response Surface Methods optimization to identify the Magnetron-PECVD conditions responsible for superlative SiOx barrier coatings on poly(ethylene terephthalate) (PET). Oxygen and water vapor permeances of optimized PET/SiOx composites produced by hexamethyldisiloxane and trimethylsilane have been measured as functions of temperature and are found to exhibit Arrhenius behavior. The thermal activation energy for water vapor permeation, unlike that for oxygen permeation, depends on barrier performance and increases by as much as 20 kJ/mol with an increase in barrier efficacy. Examination of these materials by phase-imaging atomic force microscopy and energy-filtered transmission electron microscopy reveals a correlation between SiOx morphology (including defects) and barrier performance. Morphological and permeation results are compared to identify some of the physical factors governing water vapor permeation through SiOx-modified polymers.
Maintenance and Selection of Stainless Steels for Architectural Application (1996)

This review describes how to prevent stainless steels as architectural member from aesthetic degradation caused by corrosion. It was mentioned that proper maintenance and appropriate selection of the materials are important, in order to let the architecture have long enough service time. Nature of atmospheric corrosion on stainless steels are discussed, using rating number method as well as recently developed spot density vs. area ratio plot technique. Results of exposure tests gave guideline for alloy selection relating role of alloying elements and environmental corrosiveness. Rusting process was well characterized by the spot density vs. area ratio chart, which may lead to a diagnostic measure for selecting conditions of cyclic corrosion tests.
Trading-off programming speed and current absorption in flash memories with the ramped-gate programming technique (2000)

This work studies the trade-off between programming speed and current absorption in flash EEPROM memories that can be achieved using a ramped-gate programming (RGP) method. The writing parallelism as a function of the programming speed is discussed and it is shown how the flexibility of the RGP scheme can be effectively used to meet very different programming requirements. In particular, the results of this paper address two significant applications: a highly parallel (2 K cells) soft-programming procedure able to remarkably tighten erased V/sub T/ distribution and a multilevel, high bandwidth (1 Mbytes/s) programming operation. For both applications, the most relevant issues for a practical use are discussed, such as the choice of drain and substrate voltages in relation to current absorption, the statistical distribution of programmed threshold voltages, and the endurance characteristics.
Metal-insulator transition of SrVO3 ultrathin films embedded in SrVO3/SrTiO3 superlattices (2020)

The metal-insulator transition (MIT) in strongly correlated oxides is a topic of great interest for its potential applications, such as Mott field effect transistors and sensors. We report that the MIT in high quality epitaxial SrVO3 (SVO) thin films is present as the film thickness is reduced, lowering the dimensionality of the system, and electron-electron correlations start to become the dominant interactions. The critical thickness of 3 u.c is achieved by avoiding effects due to off-stoichiometry using optimal growth conditions and excluding any surface effects by a STO capping layer. Compared to the single SVO thin films, conductivity enhancement in SVO/STO superlattices is observed. This can be explained by the interlayer coupling effect between SVO sublayers in the superlattices. Magnetoresistance and Hall measurements indicate that the dominant driving force of MIT is the electron–electron interaction.
Acute and Long-Term Effects of SMS 201-995 in Acromegaly (1986)

AbstractLamberts SWJ, del Pozo E. Acute and long-term effects of SMS 201-995 in acromegaly.The subcutaneous administration of 50 μg SMS 201-995 at 0815 h in 18 acromegalic patients reduced plasma growth hormone (GH) levels from 2 to 6 h after injection from 36 ± 2 to 7 ± 1 μg/l (-80 ± 5%). Circulating GH concentrations had normalized to less than 5 μg/l during this period in 11 of 18 patients. Postprandial blood glucose levels after breakfast were significantly (p < 0.01) higher after SMS administration but significantly lower (p < 0.01) after supper. Chronic treatment of five acromegalic patients with 200-300 μg SMS 201-995 daily for 8-24 weeks resulted in a rapid clinical improvement in all patients and complete disappearance of the complaints in four of five patients. This was accompanied by tumour shrinkage as estimated by computerized tomography scanning in three of four patients. In parallel. mean plasma GH levels and serum somatomedin-C and phosphorus levels fell to or within the normal values. SMS 201-995 represents a new tool in the medical management of acromegaly and may become the treatment of choice, especially in patients who do not benefit sufficiently from surgery and/or radiotherapy.Key Words: Acromegalygrowth hormonepituitary tumoursomatomedin-Csomatostatin
Effects of cyclosporin a and verapamil on the intracellular daunorubicin accumulation in chinese hamster ovary cells with increasing levels of drug‐resistance (1989)

Multidrug-resistance (MDR) is characterized by the presence of a 170 kDa glycoprotein (P-glycoprotein) in the plasma membrane. P-glycoprotein is thought to act as an efflux pump, leading to reduced drug accumulation in MDR cells. This defect in drug accumulation can be overcome by membrane transport modulating agents (MTMAs). We determined the concentration of MTMA needed for maximal restoration of daunorubicin content in 4 Chinese hamster ovary cell lines with increasing levels of drug-resistance using flow cytometry. Stimulation of daunorubicin accumulation occurred in a dose-dependent manner. The required level of MTMA needed for maximal drug accumulation increased with the level of drug-resistance. CHrA3 cells, which have a level of resistance comparable to clinical samples, needed relatively low concentrations of MTMA for maximal restoration of drug accumulation. This indicates that, in trial combining drugs and MTMAs, low dosages of MTMAs could be sufficient for optimal potentiation of cytotoxicity.