gebhart/patrepeval huggingface dataset:
How CT happened: the early development of medical computed tomography (2021)

As we arrive at the 50th anniversary of the first computed tomography (CT) scan of a live patient, we take this opportunity to revisit the history of early CT development. It is not an exaggeration to say that the invention of CT may represent the greatest revolution in medical imaging since the discovery of x-rays. We cover events over a period of about two decades that started with the realization that accurate cross-sectional soft-tissue detail is possible and could be a significant advance. We describe in some detail the development of the first CT system and then the rapid technical advances during the following years that included the entry of many companies into the field and the circumstances that led many of those entrants to exit the field. Rather than focusing on the specific technical details (which can be found elsewhere), we include stories and events in the hope that broader lessons can be learned. As the first x-ray-based digital imaging modality, CT brought into common use an exceptional tool that benefits countless patients every day. It also introduced dramatic changes to biomedical imaging as a field that continues to influence progress to this day.
Ipilimumab in anti-PD1 refractory metastatic melanoma (2015)

Targeted therapy and immunotherapy in metastatic melanoma have led to a marked improvement in patients' survival and their quality of life. Although there are data on anti-programmed-death-receptor-1 (anti-PD1) after ipilimumab, only few data are available on ipilimumab following anti-PD1 as the first-line treatment. The aim of our study was to evaluate tolerance and survival of patients treated with ipilimumab as the second-line immunotherapy among metastatic melanoma patients following anti-PD1 treatment. Retrospective and descriptive epidemiological studies were carried out at the Dermatology Department of the University Hospital of Lille. We describe a case series of patients treated with ipilimumab after anti-PD1 failure for metastatic melanomas. For each patient, we assessed disease extension since ipilimumab introduction using RECIST 1.1. The time between ipilimumab introduction and other systemic treatment and overall survival (between ipilimumab introduction and last patient visit) was assessed. The effect of ipilimumab after anti-PD1 treatment was evaluated in eight patients. Four patients responded to ipilimumab: three showed a complete response and one showed a partial response. For these patients, the time period between the first ipilimumab injection and another systemic treatment ranged from 209 to 391 days and the overall survival ranged from 314 to 581 days. One patient showed grade 3 chorioretinitis, an unusual toxicity with ipilimumab or anti-PD1 to our knowledge. We have described the efficacy of ipilimumab following anti-PD1 in metastatic melanoma in eight patients. Several comparative studies are still in progress, and their results will be important to develop an optimal therapeutic strategy for our patients.
Efficacy of a Combination of N-Palmitoylethanolamide, Beta-Caryophyllene, Carnosic Acid, and Myrrh Extract on Chronic Neuropathic Pain: A Preclinical Study (2019)

Neuropathic pain (NP) is a common public health problem that poses a major challenge to basic scientists and health-care providers. NP is a complex problem with an unclear etiology and an often-inadequate response to current medications. Despite the high number of drugs available, their limited pharmacological efficacy and side effects hamper their chronic use. Thus, the search for novel treatments is a priority. In addition to pharmaceuticals, natural extracts and food supplements are often used to help treating patients with NP. One such supplement is Noxiall<sup>®</sup>, a commercially available combination of N-Palmitoylethanolamide (PEA), beta-caryophyllene; carnosic acid and myrrh. Here, we compare the efficacy of Noxiall<sup>®</sup> to that of the medications gabapentin and pregabalin in the NP model of chronic constriction injury (CCI) using sciatic nerve ligation in mouse. Following CCI, mice developed a significant increase in mechanical allodynia and thermal hyperalgesia. Results showed that administration of either Noxiall<sup>®</sup>, pregabalin, or gabapentin significantly attenuated mechanical allodynia. The magnitude of the Noxiall<sup>®</sup> effect was comparable to that of gabapentin or pregabalin. In addition, co-administration of non-effective doses of pregabalin and Noxiall<sup>®</sup> resulted in a significant decrease in NP, suggesting an additive efficacy. Noxiall<sup>®</sup> was efficacious also in reducing CCI-induced thermal hyperalgesia. These findings support the rationale of using natural remedies in conjunction with classical pharmacological agents to treat chronic NP.
DCLK1 and its interaction partners: An effective therapeutic target for colorectal cancer (Review) (2021)

Doublecortin-like kinase protein 1 (DCLK1) is a microtubule-associated protein with a C-terminal serine/threonine kinase domain. Its expression was first reported in radial glial cells, where it serves an essential role in early neurogenesis, and since then, other functions of the DCLK1 protein have also been identified. Initially considered to be a marker of quiescent gastrointestinal and pancreatic stem cells, DCLK1 has recently been identified in the gastrointestinal tract as a marker of tuft cells. It has also been implicated in different types of cancer, where it regulates several vital pathways, such as Kras signaling. However, its underlying molecular mechanisms remain unclear. The present review discusses the different roles of DCLK1 and its interactions with other proteins that are homologically similar to DCLK1 to develop a novel therapeutic strategy to target cancer cells more accurately.
Viral polymerase inhibitors T-705 and T-1105 are potential inhibitors of Zika virus replication (2017)

Since 2015, 69 countries and territories have reported evidence of vector-borne Zika virus (ZIKV) transmission. Currently, there are no effective licensed vaccines or drugs available for the treatment or prevention of ZIKV infection. We tested a series of compounds for their ability to inhibit ZIKV replication in cell culture. The compounds in T-705 (favipiravir) and T-1105 were found to have antiviral activity, suggesting that these compounds are promising candidates for further development as specific antiviral drugs against ZIKV.
Validation of a New Contactless and Continuous Respiratory Rate Monitoring Device Based on Ultra-Wideband Radar Technology (2021)

Respiratory rate (RR) is typically the first vital sign to change when a patient decompensates. Despite this, RR is often monitored infrequently and inaccurately. The Circadia Contactless Breathing Monitor™ (model C100) is a novel device that uses ultra-wideband radar to monitor RR continuously and un-obtrusively. Performance of the Circadia Monitor was assessed by direct comparison to manually scored reference data. Data were collected across a range of clinical and non-clinical settings, considering a broad range of user characteristics and use cases, in a total of 50 subjects. Bland-Altman analysis showed high agreement with the gold standard reference for all study data, and agreement fell within the predefined acceptance criteria of ±5 breaths per minute (BrPM). The 95% limits of agreement were -3.0 to 1.3 BrPM for a nonprobability sample of subjects while awake, -2.3 to 1.7 BrPM for a clinical sample of subjects while asleep, and -1.2 to 0.7 BrPM for a sample of healthy subjects while asleep. Accuracy rate, using an error margin of ±2 BrPM, was found to be 90% or higher. Results demonstrate that the Circadia Monitor can effectively and efficiently be used for accurate spot measurements and continuous bedside monitoring of RR in low acuity settings, such as the nursing home or hospital ward, or for remote patient monitoring.
Ezrin interacts with S100A4 via both its N- and C-terminal domains (2017)

Ezrin belongs to the ERM (ezrin, radixin, moesin) protein family that has a role in cell morphology changes, adhesion and migration as an organizer of the cortical cytoskeleton by linking actin filaments to the apical membrane of epithelial cells. It is highly expressed in a variety of human cancers and promotes metastasis. Members of the Ca2+-binding EF-hand containing S100 proteins have similar pathological properties; they are overexpressed in cancer cells and involved in metastatic processes. In this study, using tryptophan fluorescence and stopped-flow kinetics, we show that S100A4 binds to the N-terminal ERM domain (N-ERMAD) of ezrin with a micromolar affinity. The binding involves the F2 lobe of the N-ERMAD and follows an induced fit kinetic mechanism. Interestingly, S100A4 binds also to the unstructured C-terminal actin binding domain (C-ERMAD) with similar affinity. Using NMR spectroscopy, we characterized the complex of S100A4 with the C-ERMAD and demonstrate that no ternary complex is simultaneously formed with the two ezrin domains. Furthermore, we show that S100A4 co-localizes with ezrin in HEK-293T cells. However, S100A4 very weakly binds to full-length ezrin in vitro indicating that the interaction of S100A4 with ezrin requires other regulatory events such as protein phosphorylation and/or membrane binding, shifting the conformational equilibrium of ezrin towards the open state. As both proteins play an important role in promoting metastasis, the characterization of their interaction could shed more light on the molecular events contributing to this pathological process.
Concurrent malaria and arbovirus infections in Kedougou, southeastern Senegal (2016)

Concurrent malaria parasite and arbovirus infections were detected in the Kedougou region from 2009 to 2013 and need to be further documented, including among asymptomatic individuals, to assess its epidemiological and clinical impact.
Scleral buckling versus primary vitrectomy in rhegmatogenous retinal detachment study (SPR study): Risk assessment of anatomical outcome. SPR study report no. 7 (2012)

Primary anatomical success is an important result for patients undergoing RRD surgery. Our data demonstrate that the final anatomical outcome is related to a higher preoperative number of breaks and cryotherapy in phakic eyes. Additional risk factors varied between phakic and pseudophakic subgroups. Our findings may be used to facilitate the prognosis of future patients with RRD.
Diverse Topic Phrase Extraction from Text Collection (2006)

Keyword extraction is an efficient approach to managing an explosion of online text on the Web. Traditionally, an abstraction of the online text is constructed though keywords, which are extracted according to a certain importance measure. One such measure is their occurrence frequency. However, previous work has not considered another important factor: the diversity of the
Comparative evaluation of UV/VIS and HPLC analytical methodologies applied for quantification of flavonoids from leaves of Bauhinia forficata (2012)

Spectrophotometric determinations (direct dilution or after acid hydrolysis) of flavonoid content in leaves of Bauhinia forficata Link, Fabaceae, from two different regions from Brazil were compared with contents of kaempferitrin quantified by HPLC analysis. The absence of kaempferitrin peak in one sample denotes the risk of LC-method failure. On the other hand, the both spectrophotometric assays showed satisfactory performance and do not underwent influence from absence of kaempferitrin. Since several flavonoids are present in the herbal material, different content of flavonoids were observed for each analytical procedure. However, a strong positive association could be detected among methods (R2>0.99). Although a conversion factor should be adopted to compare procedures, the data showed that the spectrophotometric methods remain as an important tool for analysis of complex matrices such herbal drugs, notably when there aren’t any pharmacological or chemical marker established for the species. Moreover, it's possible to suggest that the techniques studied in this work exhibit similar performance under the conditions employed. Nevertheless, before the adoption of kaempferitrin as an analytical marker by HPLC for Bauhinia species, the pharmacological knowledge should be better developed. In this cases, the use of spectrophotometric assay provide higher assurance of the reproducibility of the efficacy and safety.
Ceramic Trap System for Passenger Cars (1994)

&lt;div class="htmlview paragraph"&gt;An automatic forced regeneration ceramic trap system with throttling before the trap, using Ce based fuel additives, for installation on light-duty diesel passenger cars is described. The system was installed on two vehicles and tested in the laboratory. The repeatability of the back pressure variation due to the soot accumulation during successive FTP cycles was determined, and the operation period of the system was defined. The operation of the system in both applications was equivalent to about 35 km of urban driving. The filtration efficiency approached 80% in FTP cycle and 90% in ECE and JAPAN 13 mode tests, while gaseous emissions and fuel consumption were practically not affected by the system.&lt;/div&gt;
Transcriptome Analysis of WIPK/SIPK-Suppressed Plants Reveals Induction by Wounding of Disease Resistance-Related Genes Prior to the Accumulation of Salicylic Acid (2013)

Salicylic acid (SA) plays a key role in plant resistance to pathogens. Accumulation of SA is induced by wounding in tobacco plants in which the expression of WIPK and SIPK, two mitogen-activated protein kinases, is suppressed. Here, the mechanisms underlying the abnormal accumulation of SA in WIPK/SIPK-suppressed plants have been characterized. SA accumulation started around 12 h after wounding and was inhibited by cycloheximide (CHX), a protein synthesis inhibitor. SA accumulation, however, was enhanced several fold when leaf discs were transferred onto CHX after floating on water for ≥6 h. Temporal and spatial analyses of wound-induced and CHX-enhanced SA accumulation suggested that wounding induces activators for SA accumulation followed by the generation of repressors, and late CHX treatment inhibits the production of repressors more efficiently than that of activators. Microarray analysis revealed that the expression of many disease resistance-related genes, including N, a Resistance (R) gene for Tobacco mosaic virus and R gene-like genes, was up-regulated in wounded WIPK/SIPK-suppressed plants. Expression of the N gene and R gene-like genes peaked earlier than that of most other genes as well as SA accumulation, and was mainly induced in those parts of leaf discs where SA was highly accumulated. Moreover, wound-induced SA accumulation was decreased by the treatments which compromise the function of R proteins. These results indicate that signaling leading to the expression of disease resistance-related genes is activated by wounding in WIPK/SIPK-suppressed plants, and induction of R gene and R gene-like genes might lead to the biosynthesis of SA.
Genetic characterization of H9N2 avian influenza virus previously unrecognized in Korea (2021)

In this study, we describe the isolation and characterization of previously unreported Y280-lineage H9N2 viruses from two live bird markets in Korea in June 2020. Genetic analysis revealed that they were distinct from previous H9N2 viruses circulating in Korea and had highest homology to A/chicken/Shandong/1844/2019(H9N2) viruses. Their genetic constellation showed they belonged to genotype S, which is the predominant genotype in China since 2010, where genotype S viruses have infected humans and acted as internal gene donors to H5 and H7 zoonotic influenza viruses. Active surveillance and control measures need to be enhanced to protect the poultry industry and public health.
Ultrafast all-optical switches based on intersubband transitions for Tb/s operation (2004)

Theoretical and experimental results on ultra-fast all-optical switches based on intersubband transitions for Tb/s operation are presented. Designs for engineering intersubband transitions (ISBT) in GaN/AlN quantum wells near communication wavelengths (~1.55 &mu;m) and for realizing all-optical switches requiring small pulse energies are discussed. Optimized designs show all-optical switching at Tb/s data rates with pulse energies as small as 200 fJ. Experimental realization of narrow line-width ISBT in GaN/AlN superlattices is also demonstrated.
Image of the Optical Grating Modulated by the Signal and Its Application to the Measurement of Strain Distribution (1964)

A treatment is given for obtaining the image from a modulated object in a projection system. A diffraction grating put on the object plane converts the entering plane wavefront from a light source into a periodic wavefront, which gives a carrier wave, and the signal to be projected is given on the carrier as an amplitude, phase, or frequency modulation. The modulated carrier wave forms its spectrum on the entrance pupil of the projection lens. The signal appears as side bands of each carrier spectrum. A narrow opaque mask put on the plane of the spectra acts as a detector, which cuts off some spectral components, and the residual spectra reveal the image of the signal on a screen. A mask whose transmittance varies as a function of position, that is, a frequency selective filter, is used to detect the signal from a frequency-modulated carrier. The method is shown to be useful to analyze the image from an object pattern composed of scanning lines or mesh points, to detect the defects of optical gratings, and to measure the strain distribution of materials under test.
OpenMeasure: Adaptive flow measurement & inference with online learning in SDN (2016)

Accurate and efficient network-wide traffic measurement is crucial for network management. Recently, Software-defined networking (SDN) has opened up new opportunities in network measurement and inference. In this work, we demonstrate an efficient flow measurement and inference framework which performs adaptive measurement with online learning. Using the reprogrammability of SDN, we assist network inference with online learning predictions and dynamically update the measurement rules network-wide to track and measure the most informative flows. To best utilize the available measurement resources, we leverage the SDN controller (with its global view) to optimally place flow monitoring rules across network switches. Using real-world data, we show that our measurement framework achieves high performance in both estimating the traffic matrix and identifying hierarchical heavy hitters.
Amphipolar Core−Shell Cylindrical Brushes as Templates for the Formation of Gold Clusters and Nanowires (2002)

Methacryloyl end-functionalized block copolymers consisting of styrene and vinyl-2-pyridine were polymerized to poly(block co-macromonomer)s with a much higher main chain than side chain degree of polymerization. Like homo-polymacromonomers these molecules exhibit the structure of cylindrical brushes. Since the vinylpyridine block is coupled to the polymerizable group, the resulting cylindrical macromolecules exhibit a core of vinylpyridine and a shell of polystyrene, thus forming an amphipolar core−shell cylindrical macromolecule. The core−shell character of the molecules was demonstrated by HRTEM utilizing selective positive staining for the core and for the core and the shell. The core of the cylindrical brushes was loaded with HAuCl4 in toluene or methylene chloride followed by reduction of the noble metal salt by the electron beam, by UV light, or by chemical reducing agents. Depending on the amount of complexed noble metal ions and the reduction conditions, either a linear array of noble metal cluster or a continuous nanowire is formed most probably within the core of the cylindrical brushes. The resulting metal nanowires are much longer than the individual core−shell macromolecules which is caused by a yet unexplained specific end-to-end aggregation of the cylindrical polymers upon loading with HAuCl4.
Vitamin E Delivery to Human Skin by a Rinse-Off Product: Penetration of α-Tocopherol versus Wash-Out Effects of Skin Surface Lipids (2004)

alpha-Tocopherol, the major biologically active form of vitamin E, represents a frequently added lipophilic compound of skin care products. Despite its emerging use in rinse-off formulations, little is known on its efficacy with respect to its deposition or its antioxidant potential in human skin. The objective of this study was to investigate whether the single use of an alpha-tocopherol-enriched rinse-off product provides effective deposition of alpha-tocopherol on human stratum corneum. To test this, forearm skin of 13 volunteers was washed either with an alpha-tocopherol-enriched rinse-off product (test product, TP) or with an alpha-tocopherol-free vehicle control (control product, CP) (contralateral arm) using a standardized wash protocol. Thereafter, skin surface lipids were extracted with pure ethanol after the wash procedure as well as after 24 h. Additionally, one group of volunteers was subjected to irradiation of their forearms with low-dose UVA (8 J/cm(2)) prior to lipid extraction. Skin lipid extracts were analyzed by high performance liquid chromatography using electrochemical detection for vitamin E and UV detection for squalene (SQ) and squalene monohydroperoxide. The results of this in vivo study demonstrated that (1) while CP treatment lowers, TP treatment strongly increases alpha-tocopherol levels of skin barrier lipids; (2) increased vitamin E deposition levels were maintained for a period of at least 24 h, and (3) TP treatment significantly inhibited photooxidation of SQ. In conclusion, the use of alpha-tocopherol-enriched rinse-off products may help to maintain the integrity of the skin barrier by providing protection against photooxidative stress at the level of skin surface lipids.
Soft, curved electrode systems capable of integration on the auricle as a persistent brain–computer interface (2015)

Recent advances in electrodes for noninvasive recording of electroencephalograms expand opportunities collecting such data for diagnosis of neurological disorders and brain-computer interfaces. Existing technologies, however, cannot be used effectively in continuous, uninterrupted modes for more than a few days due to irritation and irreversible degradation in the electrical and mechanical properties of the skin interface. Here we introduce a soft, foldable collection of electrodes in open, fractal mesh geometries that can mount directly and chronically on the complex surface topology of the auricle and the mastoid, to provide high-fidelity and long-term capture of electroencephalograms in ways that avoid any significant thermal, electrical, or mechanical loading of the skin. Experimental and computational studies establish the fundamental aspects of the bending and stretching mechanics that enable this type of intimate integration on the highly irregular and textured surfaces of the auricle. Cell level tests and thermal imaging studies establish the biocompatibility and wearability of such systems, with examples of high-quality measurements over periods of 2 wk with devices that remain mounted throughout daily activities including vigorous exercise, swimming, sleeping, and bathing. Demonstrations include a text speller with a steady-state visually evoked potential-based brain-computer interface and elicitation of an event-related potential (P300 wave).