gebhart/patrepeval huggingface dataset:
Hypertension Primer: The Essentials of High Blood Pressure (1993)

ow in its thoroughly updated Second Edition, the Hypertension Primer is a comprehensive, readable source of state-of-the-art scientific and clinical information on hypertension. The book contains 158 short chapters by distinguished experts that cover every aspect of hypertension and its pathogenesis, epidemiology, impact, and management. The chapters are grouped into three well-organized sections--basic science, population science, and clinical management--and each chapter is cross-referenced to other relevant chapters. Each chapter is easily digestible and begins with a bulleted list of key points
MACA-a New Channel Access Method for Packet Radio (1990)

n a The existing Carrier Sense Multiple Access (CSMA) method widely used i mateur packet radio on shared simplex packet radio channels frequently suffers from l the well-known hidden terminal problem and the less well known but related prob em of the exposed terminal. This paper proposes a new scheme, Multiple Access c with Collision Avoidance (MACA), that could greatly relieve these problems. MACA an also be easily extended to provide automatic transmitter power control. This could increase the carrying capacity of a channel substantially.
Comment on 'Flow visualisation with stroboscopic illumination to provide an unambiguous record of direction' (1985)

A recent article (Hampshire 1984) describes a stroboscopic illumination technique for determining the direction of motion of tracer particles illuminated by a beam of light. The required temporal marking of particle trajectories is achieved by varying the period of illumination using a mechanical chopper which has been modified to give flashes of unequal duration separated by a short extinction. A previously published paper (Popovich and Weinberg 1983) includes a description of an identical technique developed for use in flow visualisation studies of turbulent buoyant flows produced by room fires. The basic principle of the modified stroboscopic illumination technique is that apertures are cut out of a circular chopper blade in such a way that their areas are in some fixed ratio, which gives rise to illumination which is modulated so that the periods of illumination are in the same ratio. An automatic image-analysis system based on a TV camera interfaced to a dedicated microprocessor has been used for the analysis of tracer particle trajectories in turbulent fire plumes, recorded on 16 mm cine film using the modified stroboscopic illumination technique (Popovich, 1982).
Loss of GdpP function in Staphylococcus aureus leads to β-lactam tolerance and enhanced evolution of β-lactam resistance (2021)

Synopsis Background We previously reported the presence of mutations in gdpP among Staphylococcus aureus strains that were obtained by serial passaging in β-lactam drugs. gdpP codes for a phosphodiesterase that cleaves cyclic-di-AMP (CDA), a newly discovered second messenger. Objectives We sought to identify the role of gdpP in β-lactam resistance of S. aureus . Methods CDA concentrations in bacterial cytosol were measured through mass-spectrometric analysis. gdpP deletion mutagenesis and their complemented strains were created in clinically relevant S. aureus strains to characterize its function. Results gdpP associated mutations among passaged strains were identified to cause loss of phosphodiesterase function, leading to increased CDA accumulation in the bacterial cytosol. Deletion of gdpP led to an enhanced ability of the bacteria to withstand a β-lactam challenge (two to three log increase in bacterial colony forming units) by promoting tolerance without enhancing MICs of β-lactam antibiotics. Our results demonstrate that increased drug tolerance due to loss of GdpP function can provide a selective advantage in acquisition of high-level β-lactam resistance and could lead to β-lactam treatment failure of S. aureus infections. Conclusions Loss of GdpP function increases tolerance to β-lactams that can lead to its therapy failure and can permit β-lactam resistance to occur more readily.
Cytokine Production Regulating Th1 and Th2 Cytokines in Hemophagocytic Lymphohistiocytosis (1997)

Hemophagocytic lymphohistiocytosis (HLH) is caused by the hyperactivation of T cells and macrophages. The clinical characteristics associated with this disease result from overproduction of Th1 cytokines including interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and tumor necrosis factor-alpha (TNF-alpha). In this study, we analyzed the production of IL-12 and IL-4, which determine Th1 and Th2 response, respectively, and IL-10, which antagonizes Th1 cytokines, in 11 patients with HLH. IL-12 was detected in plasma in all patients (mean peak value, 30.0 +/- 5.0 pg/mL), while IFN-gamma was massively produced in nine patients (mean peak value, 79.2 +/- 112.0 U/mL). IL-4 was not detected in any of the patients. Plasma IL-10 levels were elevated in all patients (mean peak value, 2,698.0 +/- 3,535.0 pg/mL). There was a positive correlation between the levels of IFN-gamma and IL-10 (P < .01). The plasma concentrations of these cytokines were initially high, before decreasing after the acute phase. However, the decrease in IL-10 levels was slower than that of IFN-gamma. Although the concentration of IL-12 was high at the acute phase, in some patients, a peak in the level was delayed until the chronic phase. Thus, in HLH, production of cytokines that promote development of Th1 cells appears to be predominant over that for Th2 cell development. Overproduction of IL-10 was also observed indicating that a mechanism suppressing hyperactivation of Th1 cells and monocytes/macrophages functions in patients with this disease.
Removal of an Intracorneal Hydrogel Implant for Hyperopia After LASIK (2007)

Intracorneal lenses may require explantation if previous laser ablative procedures fail to correct refractive errors.
The effect of age on the thermal resistance of arthroconidia from Chrysosporium inops (1996)

J. L. KINDERLERER. 1996. Food-borne members of the genus Chrysosporium have been isolated relatively infrequently. The heat resistance of arthroconidia of the xerophilic fungus, Chrysosporium inops Carmichael, was determined in 0.1% peptone at 66d̀C. The survival curve was sigmoid in shape. The initial lag period was due to the chains of arthroconidia. Thermal inactivation occurred when one viable conidium was left per chain. The presence of chains of arthroconidia was confirmed with the cryo scanning electron microscope. The decimal reduction times were obtained from the regression line of the linear death phase for the heat-sensitive spores. The decimal reduction time (D66) increased with increasing spore age. It was 1.67 min for 3-week-old spores, 1.95 min for 4-week-old spores and 5.49 min for 6-week-old spores. The older spores could recover from thermal death if they were given sufficient time. There was a significant increase in D66 value for 6-week-old spores from 3.97 min to 5.49 when the counts were obtained after 14 d incubation (compared to counts after incubation for 10 d). This effect was not seen for the 3- and 4-week-old spores. There was a small population of heat-resistant spores. The initial population of arthroconidia was greater than log 7 cfu ml-1. After heating for 1 h at 66d̀C approximately log 2.2 cfu ml-1 survived. These survivors represented approximately 0.001% of the original population.
Charge carrier chemistry in methylammonium lead iodide (2018)

Both electronic and ionic transport properties are key issues in the performance of perovskite solar cells. In order to understand the electrical behavior of organic-inorganic halide perovskites, and the possibilities to influence them, the elucidation of their equilibrium charge carrier chemistry as a function of stoichiometry and dopant concentration is a necessary and fundamental prerequisite. We provide here insight into the point defect chemistry of methylammonium lead iodide, whereby the decisive carriers are identified and their concentrations discussed as a function of stoichiometry (iodine partial pressure) and dopant content (oxygen partial pressure or Na addition). The experimental results indicate how ionic conductivity, which can be attributed to iodine vacancies, and electronic conductivity, which can be attributed to electron holes (or conduction electrons under reducing conditions), can be significantly and systematically altered by such treatments. Experimental results are discussed in the context of simple defect chemical models.
Overlap between in vitro donor antihost and in vivo posttransplantation TCR Vβ use: a new paradigm for designer allogeneic blood and marrow transplantation (2008)

Following allogeneic blood and marrow transplantation (BMT), mature donor T cells can enhance engraftment, counteract opportunistic infections, and mount graft-versus-tumor (GVT) responses, but at the risk of developing graft-versus-host disease (GVHD). With the aim of separating the beneficial effects of donor T cells from GVHD, one approach would be to selectively deplete subsets of alloreactive T cells in the hematopoietic cell inoculum. In this regard, TCR Vbeta repertoire analysis by CDR3-size spectratyping can be a powerful tool for the characterization of alloreactive T-cell responses. We investigated the potential of this spectratype approach by comparing the donor T-cell alloresponses generated in vitro against patient peripheral blood lymphocytes (PBLs) with those detected in vivo posttransplantation. The results indicated that for most Vbeta families that exhibited alloreactive CDR3-size skewing, there was a robust overlap between the in vitro antipatient and in vivo spectratype histograms. Thus, in vitro spectratype analysis may be useful for determining the alloreactive T-cell response involved in GVHD development and, thereby, could serve to guide select Vbeta family depletion for designer transplants to improve outcomes.
Cloning and Characterization of a Novel Mammalian Zinc Transporter, Zinc Transporter 5, Abundantly Expressed in Pancreatic β Cells (2002)

Intracellular homeostasis for zinc is achieved through the coordinate regulation of specific transporters engaged in zinc influx, efflux, and intracellular compartmentalization. We have identified a novel mammalian zinc transporter, zinc transporter 5 (ZnT-5), by virtue of its similarity to ZRC1, a zinc transporter of Saccharomyces cerevisiae, a member of the cation diffusion facilitator family. Human ZnT-5 (hZnT-5) cDNA encodes a 765-amino acid protein with 15 predicted membrane-spanning domains. hZnT-5 was ubiquitously expressed in all tested human tissues and abundantly expressed in the pancreas. In the human pancreas, hZnT-5 was expressed abundantly in insulin-containing beta cells that contain zinc at the highest level in the body. The hZnT-5 immunoreactivity was found to be associated with secretory granules by electron microscopy. The hZnT-5-derived zinc transport activity was detected using the Golgi-enriched vesicles prepared from hZnT-5-induced HeLa/hZnT-5 cells in which exogenous hZnT-5 expression is inducible by the Tet-on gene regulation system. This activity was dependent on time, temperature, and concentration and was saturable. Moreover, zinc at a high concentration (10 mm) inhibited the growth of yeast expressing hZnT-5. These results suggest that ZnT-5 plays an important role for transporting zinc into secretory granules in pancreatic beta cells.
Strengthening Mechanisms to Prioritize, Coordinate, Finance, and Execute R&D to Meet Health Needs in Developing Countries (2013)

Executive Summary In response to issues raised in the report of the World Health Organization (WHO)-affiliated Consultative Expert Working Group (CEWG) on research and development (R&D) financing and coordination and […]
ChemInform Abstract: Synthesis of Oligonucleotides Containing N2‐(2‐(Imidazol‐4‐ylacetamido) ethyl)‐2′‐deoxyguanosine. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Measurements of risk and rationality in civil engineering (1983)

This paper addresses the problem of quantifying engineering judgement. Its influence on civil engineering design and construction is measured by the statistical analysis of an opinion survey taken amongst a large cross section of practising civil engineers in Australia. The success of this survey permitted an examination of such matters as the value of experience; risk aversion (under various constraints - financial, reputational, life and disability) in critical and non critical, public and personal situations; tolerance levels for risk; intrinsic safety factors; and analytic transitivity (rationality). These measured perceptions of risk are compared with observed failure and error rates. The implications of the survey findings for error minimisation, legal penalties, cost benefit analysis, insurances and specifications are discussed (a).
Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis (2019)

As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Fiering et al., 2015) that described how we intended to replicate selected experiments from the paper 'Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis' (Goetz et al., 2011). Here we report the results. Primary mouse embryonic fibroblasts (pMEFs) expressing caveolin 1 (Cav1WT) demonstrated increased extracellular matrix remodeling <i>in vitro</i> compared to Cav1 deficient (Cav1KO) pMEFs, similar to the original study (Goetz et al., 2011). <i>In vivo</i>, we found higher levels of intratumoral stroma remodeling, determined by fibronectin fiber orientation, in tumors from cancer cells co-injected with Cav1WT pMEFs compared to cancer cells only or cancer cells plus Cav1KO pMEFs, which were in the same direction as the original study (Supplemental Figure S7C; Goetz et al., 2011), but not statistically significant. Primary tumor growth was similar between conditions, like the original study (Supplemental Figure S7Ca; Goetz et al., 2011). We found metastatic burden was similar between Cav1WT and Cav1KO pMEFs, while the original study found increased metastases with Cav1WT (Figure 7C; Goetz et al., 2011); however, the duration of our <i>in vivo</i> experiments (45 days) were much shorter than in the study by Goetz et al. (2011) (75 days). This makes it difficult to interpret the difference between the studies as it is possible that the cells required more time to manifest the difference between treatments observed by Goetz et al. We also found a statistically significant negative correlation of intratumoral remodeling with metastatic burden, while the original study found a statistically significant positive correlation (Figure 7Cd; Goetz et al., 2011), but again there were differences between the studies in terms of the duration of the metastasis studies and the imaging approaches that could have impacted the outcomes. Finally, we report meta-analyses for each result.
Effect of Ursodeoxycholic Acid on Liver Function in Children After Successful Surgery for Biliary Atresia (2008)

Our study demonstrates the beneficial effect of ursodeoxycholic acid on liver function in children after successful surgery for biliary atresia.
Wireless sensing and power transfer in a rotary tool (2015)

An innovative system, which pairs an RFID-based passive sensor link with a ferrite-based power CET unit, is designed for a temperature-controlled heating system remotely located in a rotary machine tool. Capacitive and inductive coupling are integrated in a unique platform to implement the wireless data and power links, respectively. This ensures at the same time compactness and absence of cross coupling between data and power transfer. The rectifying part of a passive RFID tag is exploited to simultaneously power and read a Pt1000 temperature probe located in a inaccessible part of the rotary tool. The procedure to design layout-wise the system is described and an extensive experimental validation is discussed.
Ordered-subset simultaneous algebraic reconstruction techniques (OS-SART) (2004)

In this paper, we first demonstrate that two ordered-subset simultaneous algebraic reconstruction techniques (OS-SART) can be heuristically derived from the perspective of data rectification. Then, we study the convergence in the framework of our recent work on the OS version of the Landweber scheme. The first OS-SART is the same as the BSSART formula, which is a special case of the OS version of the Landweber scheme. Hence, it converges in the weighted least square sense even in the case of inconsistent data. Both the OS-SART formulas are tested for reconstruction of CT images from practical data.
Rydberg Ensemble for Quantum Networking (2020)

We present a high efficiency single photon source based on a Rydberg ensemble. Additionally, we demonstrate Hong Ou Mandel interference between photons from this source and photons generated from a trapped barium ion.
The Effects of DNA Methyltransferase Inhibitors and Histone Deacetylase Inhibitors on Digit Regeneration in Mice (2010)

5-aza-dC and TSA treatments stimulated cell proliferation at the amputation site, possibly via increased expression of genes involved in digit development and regeneration.
Decomposition and nitrogen release from decomposing woody roots in coniferous forests of the Pacific Northwest: a chronosequence approach (2001)

Decomposition of woody roots in Sitka spruce (Picea sitchensis (Bong.) Carrière), Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco), and ponderosa pine (Pinus ponderosa P. Laws. ex C. Laws.) dominated forests in Oregon, U.S.A. was studied using a chronosequence. Roots of five coniferous species were excavated from stumps with ages up to 46 years old. In order of increasing decomposition rate constant (k) the species were Douglas-fir < Sitka spruce < lodgepole pine (Pinus contorta Dougl. ex Loud.) < western hemlock (Tsuga heterophylla (Raf.) Sarg) < ponderosa pine. Variation in the proportion of bark, wood, and resin cores was correlated to these differences. Root wood showed the highest k, root bark the second, and resin cores the lowest. The occurrence of resin cores in woody roots of Douglas-fir, Sitka spruce, and lodgepole pine greatly slowed the decomposition of these species. White rots occurred frequently in ponderosa pine and lodgepole pine, whereas brown rots mostly appeared in Douglas-fir and Sitka spruce. Species with white rot had a higher k than those with brown rot. Decomposing woody roots started to release N after 20–30% mass loss, a point when the dead root C/N ratio averaged 140.
Cracking phenomena in twin roll strip casting of steel (2002)

In thin strip casting of steel surface cracks may occur; it was analysed which influencing parameters are important and how the cracks can be avoided. The studies, mainly with C60-steel, lead to the following results: the cracks are formed during the casting process under high temperatures; on the strip surface hot and colder areas occur, and the cracks have to be studied in both areas separately; mostly transverse cracks are formed; the crack density depends on roll material, - force, - roughness, - surface layers; the cracks are initiated by a temperature break down and by rolling within the pool range. Oberflächenrisse beim Dünnbandgießen von Stahl. Beim Dünnbandgießen von Stahl können Oberflächenrisse auftreten; es wurde untersucht, von welchen Einflussparametern das abhängt und wie man es vermeiden kann. Systematische Untersuchungen, hauptsächlich an C60, lieferten folgende Ergebnisse: die Risse entstehen während des Gießprozesses, d.h. bei hohen Temperaturen; sie sind in den heißer oder kälter aus den Rollen austretenden Bandstellen gesondert zu untersuchen; es treten hauptsächlich Querrisse auf; die Rissdichte hängt ab von Rollenmaterial, -kraft, -rauhigkeit, -beschichtung; die Risse werden durch Spannungen verursacht, die auf einen Temperaturabsturz im Pool und durch eine im Pool auftretende Umformung zurückgehen.
ChemInform Abstract: DIREKTE KOHLENSTOFF‐ALKYLIERUNG CYCLISCHER ALPHA‐DIKETONE (1973)

Abstract Das Hydroxy‐cyclohexenon (I) wird in Tetrahydrofuran bei ‐78°C mit zwei Äquivalenten Lithiumdiisopropylamid umgesetzt.
Piezoelectric Properties of KNbO3Ceramics Prepared by Ordinary Sintering (2007)

Potassium niobate, KNbO 3 (KN), ceramics were prepared by the modified conventional ceramic fabrication process to characterize their piezoelectric properties. KN single crystal has high electromechanical coupling factor k 33 = 0.66. On the other hand, the difficulty in obtaining dense and nondeliquescent KN ceramics by conventional methods limits our knowledge of the piezoelectricity of this ceramic. The KN ceramics showed the piezoelectric properties such as the electromechanical coupling factor k 33 , the piezoelectric constant, d 33 , and the mechanical quality factor, Q m, were 0.49, 91.7 pC/N and 325, respectively. This sample was poled at a DC electric field of 5 kV/mm at 150°C.
Antimony-Templated Macrolactamization of Tetraamino Esters. Facile Synthesis of Macrocyclic Spermine Alkaloids, (±)-Buchnerine, (±)-Verbacine, (±)-Verbaskine, and (±)-Verbascenine (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTAntimony-Templated Macrolactamization of Tetraamino Esters. Facile Synthesis of Macrocyclic Spermine Alkaloids, (±)-Buchnerine, (±)-Verbacine, (±)-Verbaskine, and (±)-VerbascenineKazuaki Ishihara, Yoshichika Kuroki, Naoyuki Hanaki, Suguru Ohara, and Hisashi YamamotoView Author Information School of Engineering, Nagoya University Furo-cho, Chikusa, Nagoya 464-01, Japan Cite this: J. Am. Chem. Soc. 1996, 118, 6, 1569–1570Publication Date (Web):February 14, 1996Publication History Received23 October 1995Published online14 February 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja953541ahttps://doi.org/10.1021/ja953541arapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views1594Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Amides,Cyclization,Organic compounds,Organic reactions,Reagents Get e-Alerts