gebhart/patrepeval huggingface dataset:
A novel biophysical based marker with multilevel, multiparameter expression for early stage cancer detection. (2019)

e20673 Background: Early stage cancer detection remains to be elusive despite of many years of efforts. In this work, a bio-physical based marker (named Cancer Differentiation Analysis (CDA)) with multi-level and multi-parameter expression features has been developed which has shown a number of clear advantages over the traditional approaches such as bio-chemistry based marker, circulating tumor cell (CTC) and circuiting DNA (ct-DNA). In stage I non-small cell lung cancer (NSCLC), sensitivity and specificity reached a record high of 85.2% and 93.0%, respectively. Methods: In this study, 832 NSCLC cancer samples with pathological information and 642 samples from healthy individuals were measured in a single blind test. Peripheral blood of each individual was drawn in EDTA tubes. One class of bio-physical property in blood samples was utilized for CDA tests. The CDA data were first processed using an algorithm built from data base and subsequently analyzed using SPSS. The results were shown in the table. Results: The results indicated that CDA technology has a very good sensitivity and specificity even at stage I (85% and 93%, respectively), which is much better than those previously reported results by other methods. Conclusions: Initial results showed that CDA technology could effectively screen NSCLC patients from healthy individuals. As a novel bio-physical based cancer detection approach with multi-level and multi-parameter expressions, CDA technology could be a potential candidate for early stage cancer screening. [Table: see text]
Simultaneous Measurement of Intraosseous and Cerebrospinal Fluid Pressures in Lumbar Region (1985)

Intraosseous pressure (IOP) and cerebrospinal fluid pressure (CSFP) in the lumbar region were measured simultaneously in two groups of patients with either spinal canal stenosis or disc herniation, to compare dynamic changes with positional changes, and to learn whether these pressure changes may have some role in the onset of claudication. IOP and CSFP showed almost the same change patterns with positional changes in two groups. They were lowest in the prone position and highest at the standing position. In standing with flexion, they were almost the same as in the prone position, but in extension they increased above the standing pressure. These dynamic pressure changes could act as a compression force to the cauda equina in the patient with spinal canal stenosis.
Relationship between fiducial points on the peripheral and central blood pressure waveforms: rate of rise of the central waveform is a determinant of peripheral systolic blood pressure (2021)

Central systolic blood pressure (cSBP, the peak of the central waveform) is usually regarded as the determinant of peripheral systolic blood pressure with amplification of peripheral systolic blood pressure (pSBP) measured with reference to cSBP. However, the earlier portion of the central waveform up to the first systolic shoulder (P1) may be the major determinant of pSBP. We performed in silico simulation studies and examined previously acquired experimental data (<i>n</i> = 131) in which peripheral and central blood pressure waveforms had been acquired both invasively and noninvasively to examine the determinants of pSBP. Measurements were made at baseline and during perturbation of hemodynamics by inotropic and vasoactive drugs. In silico simulations using a central-to-peripheral transfer function demonstrated that pSBP is dependent on P1 and the rate of change (dP/d<i>t</i>) of central pressure up to the time of P1 but not cSBP. In computational simulations, peripheral reflection in the radial artery was closely related to dP/d<i>t</i>, and 97% of the variability in amplification as measured with reference to P1 was explained by dP/d<i>t</i>. In vivo, amplification of pSBP over P1 was correlated with dP/d<i>t</i> (<i>R</i> > 0.75, <i>P</i> < 0.0001 for all data sets), and P1 and dP/d<i>t</i> were independently correlated with pSBP, explaining 90% of the variability in pSBP. We conclude that P1 and dP/d<i>t</i> are major determinants of pSBP and that pSBP and cSBP are, in part, determined by different cardiac, central, and peripheral vascular properties.<b>NEW & NOTEWORTHY</b> Peripheral systolic BP is determined mainly by the first shoulder and the rate of rise of the central systolic blood pressure waveform rather than the peak of this waveform (central systolic BP). Peripheral and central systolic blood pressure are determined by different cardiac and vascular properties.
POROSITY PROPERTIES OF VACUUM FREEZE DRIED AND D-DRIED HARDENED CEMENT SPECIMENS MEASURED BY MERCURY INTRUSION POROSIMETRY (2012)

筆者等はエトリンガイトの脱水に着目して、水銀圧入測定用試料の真空凍結乾燥法の乾燥条件を提案し報告を行った。本研究は提案した乾燥法と一般的に行われているD-dry法で乾燥した普通ポルトランドセメントおよび超速硬セメント硬化体試料の細孔性状を水銀圧入法によって測定し、乾燥法の相違が水銀圧入法による細孔性状測定結果におよぼす影響について比較検討をしたものである。その結果、提案を行った乾燥法による乾燥試料はD-dry法による乾燥試料に比して0.2μm～0.015μm間の細孔が増加し、0.15μm～0.0037μm間の細孔が減少した。また、全細孔量は提案を行った乾燥法による試料に対し、D-dry法による乾燥試料は1.04～1.41倍に増加し、細孔性状は提案した乾燥条件とD-dry法で乾燥した場合と異なる測定結果が示された。
270. Polynucleotides. Part I. Synthesis and properties of some polyribonucleotides (1959)

A. M. Michelson, J. Chem. Soc., 1959, 1371 DOI: 10.1039/JR9590001371
Asymmetric synthesis of aminophosphonic acids mediated by chiral sulfinyl auxiliary: Recent advances (2010)

New approaches to asymmetric synthesis of α-, β- and γ-aminophosphonic acids using enantiopure p -toluenesulfinimines as key reagents are reported. The utility of the devised methods is illustrated by the syntheses of enantiomeric aminophosphonic acids such as AP4, AP3, and its 3-amino isomer.
Performance of Asynchronous Time-Spreading and Spectrally Coded OCDMA Systems (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The performance of asynchronous coherent time-spreading optical code-division multiple-access (OCDMA) systems is evaluated semi-analytically and the results are compared with those of spectral coding OCDMA systems using ultrashort pulses. The fundamental multi-access interference limited performances are predicted to be identical. </para>
Comparison of genetic maps for two Leptospira interrogans serovars provides evidence for two chromosomes and intraspecies heterogeneity (1993)

Genetic maps were constructed for Leptospira interrogans serovars icterohaemorrhagiae and pomona. Previously we independently constructed physical maps of the genomes for these two serovars. The genomes of both serovars consist of a large replicon (4.4 to 4.6 Mb) and a small replicon (350 kb). Genes were localized on the physical maps by using Southern blot analysis with specific probes. Among the probes used were genes encoding a variety of essential enzymes and genes usually found near bacterial chromosomal replication origins. Most of the essential genes are on the larger replicon of each serovar. However, the smaller replicons of both serovars contain the asd gene. The asd gene encodes aspartate beta-semialdehyde dehydrogenase, an enzyme essential in amino acid and cell wall biosyntheses. The finding that both L. interrogans replicons contain essential genes suggests that both replicons are chromosomes. Comparison of the genetic maps of the larger replicons of the two serovars showed evidence of large rearrangements. These data show that there is considerable intraspecies heterogeneity in L. interrogans.
Analysis of comorbid factors that increase the COPD assessment test scores (2014)

Clinical trial registered with UMIN (UMIN000003470).
Spatial Dynamics of Human-Origin H1 Influenza A Virus in North American Swine (2011)

The emergence and rapid global spread of the swine-origin H1N1/09 pandemic influenza A virus in humans underscores the importance of swine populations as reservoirs for genetically diverse influenza viruses with the potential to infect humans. However, despite their significance for animal and human health, relatively little is known about the phylogeography of swine influenza viruses in the United States. This study utilizes an expansive data set of hemagglutinin (HA1) sequences (n = 1516) from swine influenza viruses collected in North America during the period 2003-2010. With these data we investigate the spatial dissemination of a novel influenza virus of the H1 subtype that was introduced into the North American swine population via two separate human-to-swine transmission events around 2003. Bayesian phylogeographic analysis reveals that the spatial dissemination of this influenza virus in the US swine population follows long-distance swine movements from the Southern US to the Midwest, a corn-rich commercial center that imports millions of swine annually. Hence, multiple genetically diverse influenza viruses are introduced and co-circulate in the Midwest, providing the opportunity for genomic reassortment. Overall, the Midwest serves primarily as an ecological sink for swine influenza in the US, with sources of virus genetic diversity instead located in the Southeast (mainly North Carolina) and South-central (mainly Oklahoma) regions. Understanding the importance of long-distance pig transportation in the evolution and spatial dissemination of the influenza virus in swine may inform future strategies for the surveillance and control of influenza, and perhaps other swine pathogens.
Effect of scavenging on the psychomotor and cognitive function of subjects sedated with nitrous oxide and oxygen inhalation. (1998)

Maximizing scavenger effectiveness using a 45 L/min evacuation rate as recommended by the National Institute of Occupational Safety and Health (NIOSH) may alter the sedation level of the dental patient. The purpose of this pilot study was to determine if scavenging at the recommended NIOSH evacuation rate reduced psychomotor and cognitive impairment as a result of inhaling nitrous oxide. Computer-administered neurobehavioral tests of human psychomotor and cognitive function previously established in controlled trials to be sensitive to nitrous oxide inhalation were employed in this blind, randomized, crossover study of 30 healthy adult subjects. The results indicated that scavenging produced statistically significant improvement in finger-tapping speed, symbol/digit coding speed, and recall accuracy. Hand/eye coordination was not improved significantly by scavenging. Enhancement of psychomotor skills and cognitive functioning was interpreted as an undesirable side effect of scavenging that could potentially influence dental patient anxiety management when using nitrous oxide inhalation. The results of this pilot study suggested that scavenger operation under the conditions tested could reduce the level of psychosedation achieved with nitrous oxide inhalation.
Analysing the capacitance–voltage measurements of vertical wrapped-gated nanowires (2008)

The capacitance of arrays of vertical wrapped-gate InAs nanowires is analysed. With the help of a Poisson-Schrödinger solver, information about the doping density can be obtained directly. Further features in the measured capacitance-voltage characteristics can be attributed to the presence of surface states as well as the coexistence of electrons and holes in the wire. For both scenarios, quantitative estimates are provided. It is furthermore shown that the difference between the actual capacitance and the geometrical limit is quite large, and depends strongly on the nanowire material.
Living carbocationic polymerization. LXII. Living polymerization of styrene,p-methylstyrene andp-chlorostyrene induced by the common ion effect (1997)

The effect of common anion producing salt, tetrabutylammonium chloride (n-Bu4NCl), on the livingness and kinetics of styrene (St), p-chlorostyrene (pClSt), and p-methylstyrene (pMeSt) polymerization initiated by the 2-chloro-2,4,4-trimethylpentane (TMPCl)/TiCl4 system has been investigated. Uncontrolled (conventional) carbocationic polymerization of St and p MeSt can be converted to living polymerization by the use of n-Bu4NCl. Under similar conditions the polymerization of p ClSt is living even in the absence of n-Bu4NCl, although the molecular weight distribution (MWD) of the polymer becomes narrower in the presence of this salt. The apparent rates of polymerizations decrease in the presence of n-Bu4NCl in proportion with the concentration of the salt. The rate of living polymerization of p ClSt is noticeably lower than that of St, while that of p MeSt is higher. The apparent rate constants, kpA, of these polymerizations have been determined, and the effects of the electron donating p Me- and electron withdrawing p Cl-substituents relative to the rate of St polymerization have been analyzed. [For part LXI, see J. Si and J. P. Kennedy, Polym. Bull., 33, 651 (1994)]. © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35: 3341–3347, 1997
Gene expression profiling analysis of solar lentigo in relation to immunohistochemical characteristics (2007)

The results of the present microarray analysis of solar lentigo, demonstrating upregulation of genes related to inflammation, fatty-acid metabolism and melanocytes and downregulation of cornified envelope-related genes, suggest that solar lentigo is induced by the mutagenic effect of repeated ultraviolet light exposures in the past, leading to the characteristic enhancement of melanin production, together with decreased proliferation and differentiation of lesional keratinocytes on the background of chronic inflammation.
ChemInform Abstract: SYNTHESIS OF 7,9‐DIDECARBOXYMETHOXATIN (4,5‐DIHYDRO‐4,5‐DIOXO‐1H‐PYRROLO(2,3‐F)QUINOLINE‐2‐CARBOXYLIC ACID) AND COMPARISON OF ITS CHEMICAL PROPERTIES WITH THOSE OF METHOXATIN AND ANALOGOUS O‐QUINONES. MODEL STUDIES DIRECTED TOWARD THE ACTION OF PQQ REQUIRING BACTERIAL OXIDOREDUCTASES AND MAMMALIAN PLASMA AMINE OXIDASE (1985)

Abstract Die Pyrrolochinolincarbonsäure (Ia) bzw. ihr Ester (Ib) werden wie angegeben ausgehend von (IIa)‐Reduktionsprodukt (IIb) dargestellt.
Synthèse de ligands disaccharidiques de la lectine PA-IIL de Pseudomonas aeruginosa impliquée dans la fibrose kystique (2007)

La fibrose kystique (FK) est la maladie génétique mortelle la plus répandue chez les jeunes &#13;\nCanadiens. La colonisation des poumons par une bactérie opportuniste, Pseudomonas aeruginosa, est la principale cause de morbidité et de mortalité chez les patients FK. La maladie est causée par des mutations du gène codant pour la protéine CFTR (Cystic Fibrosis Transmembrane conductance Regulator) qui agit comme canal à ions chlorures. Ces modifications entraînent notamment une surexpression d'oligosaccharides fucosylés à la surface de l'épithélium pulmonaire. Le processus d'adhésion de la bactérie à la surface des cellules de l'épithélium pulmonaire est causé par la présence de deux lectines à la surface de la bactérie. Nous nous intéressons principalement à l'une d'entre elles, une lectine calcium dépendante qui reconnaît particulièrement le L-fucose (PA-IlL). Des études cristallographiques menées sur PA-IlL, en complexe avec divers ligands naturels tel que le Lewis a, ont permis d'identifier plusieurs éléments essentiels à l'obtention d'une forte interaction ligand-lectine. Basé sur ces études, le projet de recherche a consisté en la synthèse de différents analogues d'un disaccharide composé d'une unité fucose et glucosamine du type L-Fuc-a(1→4)-D-GIcNAcβ intimement impliqué dans le site de liaison de la protéine. Différents glycoclusters du disaccharide ont été synthétisés en utilisant la 'Click Chemistry'. De plus, quelques disaccharides modifiés en position C-2 et C-6 ont aussi été synthétisés. Les disaccharides ainsi que les glycoclusters ont été testés sur la PA-IlL en utilisant un test d'inhibition compétitive (ELLA). Les dérivés disaccharidiques ont montrés une constante de dissociation (Kd = 310 nM) dans le même ordre de grandeur que celle du meilleur ligand naturel Lewis a (Kd = 210 nM) connu jusqu'à maintenant pour la PA-IlL. ______________________________________________________________________________ MOTS-CLÉS DE L’AUTEUR : Pseudomonas aeruginosa, Fibrose kystique, Lectine PA-IlL, Lewis a, Glycosylation, «click chemistry», Glycoclusters.
The detection and management of root resorption lesions using intraoral radiography and cone beam computed tomography – an in vivo investigation (2009)

CBCT was effective and reliable in detecting the presence of resorption lesions. Although digital intraoral radiography resulted in an acceptable level of accuracy, the superior accuracy of CBCT may result in a review of the radiographic techniques used for assessing the type of resorption lesion present. CBCT's superior diagnostic accuracy also resulted in an increased likelihood of correct management of resorption lesions.
Internet Small Computer Systems Interface (iSCSI) (2004)

This document describes a transport protocol for Internet Small Computer Systems Interface (iSCSI) that works on top of TCP.The iSCSI protocol aims to be fully compliant with the standardized SCSI architecture model.SCSI is a popular family of protocols that enable systems to communicate with I/O devices, especially storage devices.SCSI protocols are request/response application protocols with a common standardized architecture model and basic command set, as well as standardized command sets for different device classes (disks, tapes, media-changers etc.).As system interconnects move from the classical bus structure to a network structure, SCSI has to be mapped to network transport protocols.IP networks now meet the performance requirements of fast system interconnects and as such are good candidates to "carry" SCSI.
Freeze Crystallization of Imipenem (1996)

This work is a study of the freeze crystallization process developed for the production of a rapidly soluble and stable crystalline form of imipenem, an antibiotic. The objective is to understand the relationship between process conditions and the product crystallinity during the freeze crystallization. Solutions of imipenem and sodium bicarbonate, a drug stabilizer, were crystallized in acetone-water solvent systems at various ratios and temperatures. The degree of crystallinity of the resulting products was measured using an X-ray powder diffraction analysis technique. The acetone-water S-L phase diagram was used to correlate the resulting degrees of crystallinity of imipenem products and equilibrium properties of the system. It was discovered that the conversion of amorphous imipenem to crystalline products was directly related to the percentage of equilibrium liquid during the freeze crystallization. Solubility data indicated that imipenem is virtually insoluble in these equilibrium liquid phases. This suggests that the phase transition from the amorphous state to the crystalline state is mediated by the presence of the liquid phase.
Relationship Between MMP-1, MMP-9, TIMP-1, IL-6 and Risk Factors, Clinical Presentation, Extent and Severity of Atherosclerotic Coronary Artery Disease (2011)

Serum levels of MMP-1, MMP-9, and IL-6 are elevated in patients with CAD; more so in acute coronary syndromes. MMP-1, MMP-9 and IL-6 are associated with more extensive and severe CAD (as represented by Gensini score).
Superacid-Catalyzed Selective Formylation–Rearrangement of Isoalkanes with Carbon Monoxide to Branched Ketones (2000)

Oktanzahlen über 100 gewährleisten verzweigte aliphatische Ketone als Additive, die durch die Titelreaktion von Isoalkanen mit Kohlenmonoxid zugänglich sind. So liefert Isobutan Methylisopropylketon in 91% Ausbeute und mit 93% Selektivität (siehe Schema). Die Reaktion liefert keine verzweigten Carbonsäuren (Produkte der Koch-Carbonylierung); sie verläuft vermutlich über eine elektrophile Substitution am tertiären Kohlenstoffatom durch das aus Kohlenmonoxid gebildete Formylkation und anschließende Umlagerung.
Hydrogen abstraction by benzophenone studied by holographic photochemistry (1981)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTHydrogen abstraction by benzophenone studied by holographic photochemistryC. Braeuchle, D. M. Burland, and G. C. BjorklundCite this: J. Phys. Chem. 1981, 85, 2, 123–127Publication Date (Print):January 1, 1981Publication History Published online1 May 2002Published inissue 1 January 1981https://pubs.acs.org/doi/10.1021/j150602a001https://doi.org/10.1021/j150602a001research-articleACS PublicationsRequest reuse permissionsArticle Views380Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Evaluating Binuclear Copper(II) Complexes for Glycoside Hydrolysis (2010)

Three binuclear copper(II) complexes were characterized as solids by X-ray diffraction and in solution by UV/vis spectrophotometric titration, and subsequently evaluated for their glycosidase-like activity. The structure analysis revealed comparable intermetallic Cu...Cu distances (approximately 3.5 A) for the complexes 2 and 3. Despite this similarity, the composition of the complexes differs significantly in aqueous solution as revealed by spectrophotometric titrations. The hydrolysis of selected nitrophenylglycopyranosides is up to 11,000-fold accelerated over background in the presence of the copper(II) complexes in 3-(cyclohexylamino)-1-propanesulfonic acid (CAPS) buffer at pH 10.5 and 30 degrees C.
The Dyeing of Polyolefin Fibers in Supercritical Carbon Dioxide. Part I: Thermo-mechanical Properties of Polyolefin Fibers after Treatment in CO2under Dyeing Conditions (1998)

The viscoelastic properties of gel-spun polyethylene (PE) and polypropylene (PP) fibers after treatment in supercritical CO2, at 280 bar were examined to determine the optimum conditions for dyeing without causing fiber damage. Above 100°C, a greater amount of shrinkage, mainly of PP fiber, is observed in CO2, than in air at 1 bar. Under isothermal conditions at 100°C, pressure-dependent on-line measurements of a PP-fiber monofli up to 280 bar show that shrinkage becomes very considerable at low pressures of only 10 bar. In comparison with isobaric conditions at 280 bar, shrinkage starts at temperatures above 60°C and is greatest between 90 and 100°C. In both cases, the degree of shrinkage is 11–12%. The value of F.max on the stress—strain diagrams of all fibers tested is not influenced by the treatment in CO2, up to 120°C. However, the elongation increases only for polyolefins with a lower degree of crystallinity to the extent of about 15% for the PP monofil and 13% for the LM-PE fiber. Furthermore, CO2, is able to penetrate into the hydrophobic PE and PP fibers and acts as a quasi-impurity, reducing the melting point (mp) of LM-PE fibers by between 5 and 7°C and that of PP monofli by 9 and 22°C at 50 and 280 bar, respectively. This was observed by differential-dynamic-heat-flow calorimetric measurements in CO2. The decrease in mp of the highly crystalline HM-PE fiber is only 2°C because the diffusion of CO2 into the fiber is extremely slow.