gebhart/patrepeval huggingface dataset:
Hybrid cache architecture with disparate memory technologies (2009)

Caching techniques have been an efficient mechanism for mitigating the effects of the processor-memory speed gap. Traditional multi-level SRAM-based cache hierarchies, especially in the context of chip multiprocessors (CMPs), present many challenges in area requirements, core-to-cache balance, power consumption, and design complexity. New advancements in technology enable caches to be built from other technologies, such as Embedded DRAM (EDRAM), Magnetic RAM (MRAM), and Phase-change RAM (PRAM), in both 2D chips or 3D stacked chips. Caches fabricated in these technologies offer dramatically different power and performance characteristics when compared with SRAM-based caches, particularly in the areas of access latency, cell density, and overall power consumption. In this paper, we propose to take advantage of the best characteristics that each technology offers, through the use of Hybrid Cache Architecture (HCA) designs. We discuss and evaluate two types of hybrid cache architectures: inter cache Level HCA (LHCA), in which the levels in a cache hierarchy can be made of disparate memory technologies; and intra cache level or cache Region based HCA (RHCA), where a single level of cache can be partitioned into multiple regions, each of a different memory technology. We have studied a number of different HCA architectures and explored the potential of hardware support for intra-cache data movement and power consumption management within HCA caches. Utilizing a full-system simulator that has been validated against real hardware, we demonstrate that an LHCA design can provide a geometric mean 7% IPC improvement over a baseline 3-level SRAM cache design under the same area constraint across a collection of 25 workloads. A more aggressive RHCA-based design provides 12% IPC improvement over the baseline. Finally, a 2-layer 3D cache stack (3DHCA) of high density memory technology within the same chip footprint gives 18% IPC improvement over the baseline. Furthermore, up to 70% reduction in power consumption over a baseline SRAM-only design is achieved.
Meu Trabalho como Terapeuta: Vivencias e Experiencias (2013)

In this text Prof. Rios gives an account of his trajectory as the oldest Family and Couple Therapist in Spain. From his graduation as a pedagogue, specializing in psychology, to the Family and Couple Therapy as an autodidact, coming from the intra-psychic to the system when trying to understand his individual patients by means of their familiar environment. With his experience of 4.183 cases in the Centro Psicopedagogico Familiar (Familiar Psycho-pedagogic Center) – Stirpe – established as of 1963, Rios describes his fears, surprises, limitations, joys and hopes as a therapist, specially valuing co-therapy as a permanent supervision
An Airborne Integrated System to Monitor CO2 Emissions – Preliminary Results in the Adriatic Seashore (2008)

CO2 emissions monitoring is one of the rising problems in a CO2 underground storage site. In this framework OGS has tested a simple methodology addressed to control the hypothetic CO2 emissions from an underground storage facility by direct airborne measurements. The study also investigates the economical aspects of such an activity. The test has been carried out using a low cost single engine IFR certified aircraft where an air sampling system, able to measure the CO2 concentration in the air, has been mounted on; a pseudo regular flight pattern has been adopted at an altitude of 2000 ft above the studied area, located in the North Eastern part of the Adriatic seashore and including some small dimension towns. In real time the system collected the position of the aircraft, the air pressure, temperature, relative humidity, wind direction and CO2 concentration values. A specific approach for data reduction to a "datum" altitude has been investigated and successfully applied. The trend of anthropic CO2 concentration has been studied, as the base for the computation of a first primitive diffusive model of CO2 flux in the air and nearby the ground. The test demonstrated the feasibility of the method.
Use of Aspirin to Reduce Risks of Cardiovascular Disease in Patients With Diabetes (2004)

In their third version of U.S. federal guidelines, the National Cholesterol Education Program Adult Treatment Panel III elevated diabetes from a major risk factor to a coronary heart disease (CHD) risk equivalent (1, 2). The rationale for this change derives, in part, from earlier observations that patients with diabetes have several-fold increased risks of CHD (3), which are even greater in women than men (4). In fact, it has been suggested that at any given age, diabetes eliminates the lower absolute risk of CHD in women compared with men. Specifically, a middle-aged woman with diabetes has an absolute risk of CHD approximately equal to her male counterpart without diabetes. Furthermore, in a prospective cohort study, nondiabetic subjects with prior CHD had a 7-year event rate of ∼18.8%, whereas diabetic subjects without prior CHD had an event rate of ∼20% (5). Whether such high absolute risks apply to patients with newly diagnosed diabetes is less clear. Nonetheless, current U.S. federal guidelines recommend that patients with diabetes be treated just as aggressively as secondary prevention patients without diabetes (i.e., those who have already experienced a CHD event).

With respect to secondary prevention, aspirin conclusively reduces risks of subsequent myocardial infarction (MI) by about one-third, stroke by about one-fourth, and vascular death by about one-sixth (6, 7). In primary prevention, aspirin conclusively reduces the risk of a first MI by about one-third, but the numbers of strokes and vascular deaths in the five published primary prevention trials preclude firm conclusions. Nonetheless, based on meta-analyses of risks (8) and benefits (9), recent U.S. Preventive Services Task Force Guidelines recommend that aspirin also be considered for all apparently …
Enumeration of illumination and scanning modes from real-time spatial light modulators (2000)

Using a phase-only spatial light modulator (SLM) in a Fourier transform setup together with fast diffractive optics design algorithms provides a way to automatically generate complex and rapidly changing laser illumination patterns in the far-field. We propose a hierarchical software structure for the adaptive, on-line design of far-field illumination patterns. Using the on-line design system together with camera feedback of the illuminated scene would make it possible to detect and actively laser designate multiple objects in parallel. Possibilities for multispot, arbitrary trajectory scanning and also broad-area speckle-reduced illumination are demonstrated with experimentally measured diffraction pattern sequences from a 120 x 128 pixel phase-only SLM.
Clinical efficacy of istradefylline (KW‐6002) in Parkinson's disease: A randomized, controlled study (2010)

The objectives of this study were to evaluate the efficacy of istradefylline at an oral dose of 20 mg or 40 mg once daily for 12 weeks in Parkinson's disease (PD) patients with motor complications on levodopa therapy based on the change in the daily OFF time compared with placebo and to assess the safety at these doses. A total of 363 subjects were randomly assigned to receive 20 mg/day istradefylline (n = 119), 40 mg/day istradefylline (n = 125), or placebo (n = 119). The primary outcome variable was the change from baseline at endpoint in daily OFF time based on patients' ON/OFF diaries. At endpoint, the daily OFF time reduced from baseline by 1.31 hours for 20 mg/day istradefylline (P = 0.013 as compared to the placebo), 1.58 hours for 40 mg/day istradefylline (P < 0.001), and 0.66 hours for placebo; istradefylline significantly reduced the daily OFF time compared with placebo. The UPDRS Part III subscale score (ON state) reduced by 5.7 at endpoint in both istradefylline groups and 3.7 in the placebo group (P = 0.006 for 20 mg/day and P = 0.006 for 40 mg/day group as compared with placebo). The most commonly reported drug-related treatment emergent adverse event (TEAE) was dyskinesia, which occurred in 2.5% (3/119) of subjects receiving placebo, 8.5% (10/118) receiving 20 mg/day istradefylline, and 6.4% (8/125) receiving 40 mg/day istradefylline. We conclude that istradefylline at 20 mg and 40 mg once daily is effective in relieving wearing-off fluctuations of PD patients. In addition, istradefylline was well tolerated at both doses.
Effectiveness of Postinoculation ( R )-9-(2-Phosphonylmethoxypropyl)Adenine Treatment for Prevention of Persistent Simian Immunodeficiency Virus SIV mne Infection Depends Critically on Timing of Initiation and Duration of Treatment (1998)

(R)-9-(2-Phosphonylmethoxypropyl)adenine (PMPA), an acyclic nucleoside phosphonate analog, is one of a new class of potent antiretroviral agents. Previously, we showed that PMPA treatment for 28 days prevented establishment of persistent simian immunodeficiency virus (SIV) infection in macaques even when therapy was initiated 24 h after intravenous virus inoculation. In the present study, we tested regimens involving different intervals between intravenous inoculation with SIV and initiation of PMPA treatment, as well as different durations of treatment, for the ability to prevent establishment of persistent infection. Twenty-four cynomolgus macaques (Macaca fascicularis) were studied for 46 weeks after inoculation with SIV. All mock-treated control macaques showed evidence of productive infection within 2 weeks postinoculation (p.i.). All macaques that were treated with PMPA for 28 days beginning 24 h p.i. showed no evidence of viral replication following discontinuation of PMPA treatment. However, extending the time to initiation of treatment from 24 to 48 or 72 h p.i. or decreasing the duration of treatment reduced effectiveness in preventing establishment of persistent infection. Only half of the macaques treated for 10 days, and none of those treated for 3 days, were completely protected when treatment was initiated at 24 h. Despite the reduced efficacy of delayed and shortened treatment, all PMPA-treated macaques that were not protected showed delays in the onset of cell-associated and plasma viremia and antibody responses compared with mock controls. These results clearly show that both the time between virus exposure and initiation of PMPA treatment as well as the duration of treatment are crucial factors for prevention of acute SIV infection in the macaque model.
177Lu-Labeled Prostate-Specific Membrane Antigen Radioligand Therapy of Metastatic Castration-Resistant Prostate Cancer: Safety and Efficacy (2016)

PSMA RLT with (177)Lu-PSMA is feasible, safe, and effective in end-stage progressive mCRPC with appropriate selection and follow-up of patients by (68)Ga-PSMA PET/CT through application of the concept of theranostics.
Comparison of Clinical and Echocardiographic Outcomes After Valve Repair: Degenerative Versus Rheumatic Mitral Regurgitation (2003)

We compared clinical (30+/-24 months) and echocardiographic follow-up (22 +/- 20 months) data of 184 consecutive patients with myxomatous degenerative mitral regurgitation (Group A) and 85 consecutive patients with rheumatic mitral regurgitation (Group B) after repair. Selection criteria for rheumatic etiology was predominant mitral regurgitation with valve area >or= 2.0 cm(2) and with no significant calcification in valvular apparatus. Repair was successful in 93% of group A and in 92% of group B (p>0.05). There was no difference of operative mortality (1% vs 0%) and of the incidence of the second-pump valve replacement (4% vs 5%). The 4-yr survival, 4-yr event-free survival, and 4-yr mitral regurgitation-free survival rates in group A were 96 +/- 2%, 89 +/- 4%, and 76 +/- 5%, respectively, which were not different from those in group B (97 +/-2 %, 93 +/- 4%, and 68 +/-7 %, p >0.05). Independent determinants of development of at least moderate regurgitation in group A were no use of ring annuloplasty (hazards ratio 6.6, 95% CI 2.0 to 21.5) and new chordae formation (hazards ratio 3.5, 95% CI 1.4 to 8.7). In group B, no use of ring annuloplasty (hazards ratio 15.3, 95% CI 3.5 to 66.7) also was independent predictor. Valve repair is highly feasible in selected patients with rheumatic mitral regurgitation, and clinical course is not significantly different from that of patients with degenerative mitral regurgitation.
ChemInform Abstract: THE STRUCTURE OF THE FLUORESCENT ADDUCT FORMED IN THE REACTION OF O‐PHTHALALDEHYDE AND THIOLS WITH AMINES (1977)

Abstract Bei der Reaktion von prim. Aminen, Aminosäuren oder Proteinen mit o‐Phthalaldehyd (I) und Thiolen wie z.B. (II) entstehen stark fluoresä zierende Verbindungen bisher unbekannter Struktur, die zum Fluoreszenznachweis geringer Mengen Aminosäuren bzw. Proteine benutzt werden.
Syntheses, characterizations and thermal analyses of four novel unsymmetrical β-diketiminates (2013)

Four novel unsymmetrical β-diketiminates 2-(2,6-diisopropylphenyl)amino-4-(phenyl)imino-2-pentene (4a), 2-(2,6-diisopropylphenyl)amino-4-(4-methylphenyl)imino-2-pentene (4b), 2-(2,6-diisopropylphenyl)amino-4-(4-methoxyphenyl)imino-2-pentene (4c) and 2-(2,6-diisopropylphenyl)amino-4-(4-chlorophenyl)imino-2-pentene (4d) were synthesized with a 77-84% yield, and were characterized by spectroscopic methods ((1)H NMR, (13)C NMR, IR and mass spectrometry), elemental analysis, and X-ray single-crystal diffraction, respectively. Spectroscopic and X-ray single-crystal diffraction analyses determined the structures of the four β-diketiminates. While thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) showed two distinct endothermic peaks for each β-diketiminate at temperatures of 92.55°C and 221.50°C (4a), 93.51°C and 238.82°C (4b), 109.60°C and 329.22°C (4c), 115.43°C and 243.25°C (4d), respectively, corresponding to their melting and boiling points.
Mechanism of the Haemotensive Action of Porcine Relaxin in Anaesthetized Rats (1990)

Abstract Experiments were done to examine the pressor effect of iv porcine relaxin in anaesthetized rats. Acute injections of relaxin caused consistent and sustained rises in systemic blood pressure that were dose-dependent within the physiological range. Pretreatment of rats with a specific vasopressin (V1) receptor antagonist, but not an alpha-adrenoreceptor antagonist, substantially reduced the pressor effect of relaxin. After the vasopressin receptor antagonist, small rises in blood pressure occurred after a longer latent period, compared with the responses in intact animals. The data clearly indicate that acute injections of relaxin cause a pressor response that is predominantly affected via the release of vasopressin. The possible sources of the persistent hypertensive component are discussed and it is suggested that relaxin might act through the central angiotensinergic systems to release vasopressin and cause a pressor response.
The global analysis of fuzzy dynamical systems (1989)

In this thesis we focus on the behavioral analysis of fuzzy dynamical systems, which has become an increasingly important issue due to the prominent success of fuzzy logic control. Fuzzy logic control was first proposed (Zadeh (1968)) as a possible application of fuzzy set theory. Many industrial applications of it have been demonstrated in the past two decades. A fuzzy logic controller utilizes the knowledge of a human expert to acquire better control strategies for a process. It starts from some simple process controls which can be easily handled by human operators, such as steam engine control. However, as the constructed fuzzy control systems become more complex and larger in scale, there is an increasing need for a systematic analysis and design methodology.
Among all the problems concerning the analysis of a fuzzy dynamical system, stability is one of the most interesting topics. In this thesis, a notion of the expert's Lyapunov function is first proposed to give an insight into the stable nature of a fuzzy control system. A cell-to-cell mapping method, which is successfully used in the nonlinear system analysis, is then adopted to attack the problem of the global analysis of a fuzzy dynamical system. An analytical method is developed to describe the behavior of a fuzzy dynamical system. Both the real and fuzzy initial state responses are also studied. A definition of cellular stability is proposed to give a complete description of the analyzed fuzzy system. A follow-up stability theorem is also formulated to provide a sufficient condition for a stable fuzzy dynamical system. To illustrate the advantages as well as the disadvantages of the fuzzy logic control, an experiment involving an inverted pendulum was conducted to compare the differences on the performance and controller design procedure between the fuzzy logic control and the more conventional state feedback control. The results of this experiment are described subsequently.
Cyclobutenone-Based Syntheses of Polyquinanes and Bicyclo[6.3.0]undecanes by Tandem Anionic Oxy-Cope Reactions. Total Synthesis of (±)-Precapnelladiene (1998)

The addition of ethenyllithium derivatives to the carbonyl of dialkyl squarate-derived bicycloheptenones, e.g., 1a and 6a, initiates a low-temperature anion-accelerated oxy-Cope rearrangement to provide polyquinanes by a transannular aldol reaction of the intermediate bicyclo[6.3.0]undecadienone 4. Additional functionality is introduced by alkylation of the enolate 3 resulting from the oxy-Cope rearrangement. Phosphorylation or triflation of enolate 3 provides an entry into the bicyclo[6.3.0]undecane ring system. An application of this new methodology is demonstrated by the total synthesis of the sesquiterpene natural product (+/-)-precapnelladiene from diisopropyl squarate (10 steps, 12%).
User-centric computational videography (2015)

Digital video is ubiquitous: virtually every mobile device comes with at least one high-resolution video camera, and users often upload video to community websites -- 300 hours of video are uploaded to YouTube alone every minute. Yet, many commercial solutions for capturing, editing and browsing videos are difficult to use for end users, and hence constrict user creativity.
Non-contact monitoring of biofilms and corrosion on submerged surfaces with electrochemical impedance spectroscopy (2023)

Systems and methods for monitoring microorganisms on a surface are provided. In particular, a flat, patterned sensing electrode can be positioned proximate a surface in non-contact relationship with the surface. The sensing electrode can include a working electrode and a counter electrode. The surface and the sensing electrode can be submerged in an aqueous medium. An alternating current signal can be applied at the working electrode. The signal can propagate through the aqueous medium and can be measured at the counter electrode. The presence of microorganisms on the surface can cause changes in the signal as the signal propagates through the aqueous medium. Such changes in the signal can be used to determine impedance parameters, which can correspond to microbial characteristics associated with the surface. For instance, the microbial characteristics can be associated with a biofilm, corrosion and/or bio-corrosion on the surface.
Semimechanistic Population Pharmacokinetic Modeling to Investigate Amyloid Beta Trafficking and Accumulation at the BBB Endothelium (2021)

Elevated exposure to toxic amyloid beta (Aβ) peptides and consequent blood-brain barrier (BBB) dysfunction are believed to promote vasculopathy in Alzheimer's disease (AD). However, the accumulation kinetics of different Aβ isoforms within the BBB endothelium and how it drives BBB dysfunction are not clearly characterized. Using single positron emission computed tomography (SPECT)-computed tomography (CT) dynamic imaging coupled with population pharmacokinetic modeling, we investigated the accumulation kinetics of Aβ40 and Aβ42 in the BBB endothelium. Brain clearance was quantified after intracerebral administration of <sup>125</sup>I-Aβ, and BBB-mediated transport was shown to account for 54% of <sup>125</sup>I-Aβ40 total clearance. A brain influx study demonstrated lower values of both maximal rate (<i>V</i><sub>max</sub>) and Michaelis constant (<i>K</i><sub>m</sub>) for <sup>125</sup>I-Aβ42 compared to <sup>125</sup>I-Aβ40. Validated by a transcytosis study in polarized human BBB endothelial cell (hCMEC/D3) monolayers, model simulations demonstrated impaired exocytosis was responsible for inefficient permeability and enhanced accumulation of Aβ42 in the BBB endothelium. Further, both isoforms were shown to disrupt the exocytosis machinery of BBB endothelial cells so that a vicious cycle could be generated. The validated model was able to capture changes in Aβ steady-state levels in plasma as well as the brain during AD progression and allowed us to predict the kinetics of Aβ accumulation in the BBB endothelium.
The Role of Innate Lymphoid Cells in Cancer Development and Immunotherapy (2022)

Innate Lymphoid Cells (ILCs) are an elusive type of innate immune cell that was only discovered recently. Their tissue residency and dependency makes them a niche group of cells that bridge the adaptive and innate immune system. The nomenclature and classification of ILCs have been challenging due to their heterogeneity. The currently agreed ILC classification splits the cells into two categories including cytotoxic and helper ILCs. The tumour microenvironment is often hostile for immune cells. Remodeling the microenvironment and regulating other immune cells-achieved by ILCs-can enhance anti-tumor effects. How ILCs regulate other immune cells in the tumor microenvironment remains to be understood. Here we review current understanding of the role of ILCs in the tumor microenvironment. ILCs recruit CD8 positive T and memory T cells in PDAC, ILCs are also able to help CD108 positive B cells migrate toward tumour locations. In NSCLC, ILC3s are seen helping resident macrophages enhancing the mucus immunity to cancer cells. We then highlight the roles of cytokines and immune checkpoint pathways in ILCs and its implication in immunotherapy.
Adaptive Model Update Algorithms for Remote Network Emulation (2008)

Remote network emulation is an approach that utilizes a remote parallel simulator to improve the scale and accuracy of network emulation for general users with no local access to high performance computing facilities. The remote network emulation approach involves using a large scale detailed packet level simulation at a remote site in conjunction with a local network emulation to quickly provide QoS predictions to real time applications. Model update algorithms are needed to keep the remote simulator and local emulator updated with each other's status, while keeping the amount of communication required to an acceptable level. In this paper two adaptive model update algorithms are explored for triggering network status updates. The first algorithm dynamically adjusts update frequency according to the real network status between the remote simulator and emulator. The second algorithm triggers updates whenever the prediction error of the network emulation exceeds a preset threshold. Preliminary experimental results show that the two algorithms can improve emulation accuracy compared with a fixed update algorithm for the scenarios that were tested.