gebhart/patrepeval huggingface dataset:
Decreased Stimulation of Adenylate Cyclase by Growth Hormone-Releasing Factor in the Anterior Pituitary of Old Rats (1986)

Adenylate cyclase activity was studied in anterior pituitary homogenates from young adult (6 months) and old (20 and 24 months) male rats. Basal, NaF-, GTP-, 5'-guanylimidodiphosphate (Gpp(NH)p)- and forskolin-stimulated activities were similar in the three groups, implying that the stimulatory guanyl nucleotide regulatory binding site (NS) and the catalytical unit were unaffected by aging. Vasoactive intestinal peptide (VIP)-stimulated adenylate cyclase activity was also identical in the three groups. The efficacy (i.e., the maximum effect) of growth hormone-releasing factor [GRF(1-29)-NH2] on adenylate activity was reduced by 45-49% in old and senescent rats with no change in peptide potency (i.e., the concentration required for half-maximal enzyme stimulation). These results suggest that aging induced a selective loss of functional GRF receptors but influenced neither the coupling between receptors, NS and the catalytic unit nor the efficacy of the catalytic unit per se.
Monolaterol, the First Configurationally Assigned Phenylphenalenone Derivative with a Stereogenic Center at C-9, from Monochoria elata (2006)

Phytochemical analysis of the roots of Monochoria elata resulted in the structure elucidation of monolaterol, the first configurationally assigned phenylphenalenone-type natural product with a stereogenic center at the phenyl-bearing carbon, C-9, and four known phenylphenalenones by MS and NMR methods. The absolute configuration of the new phenyldihydrophenalenediol was assigned by comparing the results of quantum chemical CD calculations and experimental CD spectra, and the crystal structure was determined by X-ray diffraction analysis.
Typed Fusion with Applications to Parallel and Sequential Code Generation (1994)

Loop fusion is a program transformation that merges multiple loops into one and is an effective optimization both for increasing the granularity of parallel loops and for improving data locality. This paper introduces typed fusion, a formulation of loop fusion which captures the fusion and distribution problems encountered in sequential and parallel program optimization. Typed fusion is more general and applicable than previous work. We present a fast algorithm for a typed fusion on a graphG=(N;E), where nodes represent loops, edges represent dependence constraints between loops and each loop is assigned one ofTdistinct types. Only nodes of the same type may fuse. Only nodes of the same type may be fused. The asymptotic time bound for this algorithm isO((N+E)T). The fastest previous algorithm considered only one or two types, but was stillO(NE)[KM93]. WhenT&amp;gt;2and there is no reason to prefer fusing one type over another, we prove the problem of finding a fusion with the fewest resultant loops to be NP-hard. Using typed fusion, we present fusion and distribution algorithms that improve data locality and a parallel code generation algorithm that incorporates compound transformations. We also give evidence of the effectiveness of this algorithm in practice. 1
Radiation Induces Up-Regulation of Somatostatin Receptors 1, 2, and 5 in Small Cell Lung Cancer In Vitro Also at Low Absorbed Doses (2011)

The binding of [(177)Lu]-DOTA(0)-Tyr(3)-octreotate was increased after radiation exposure. This increase was observed at low absorbed doses in parallel with up-regulation of sstr1, sstr2, and sstr5 mRNA.
Explaining the parameters of the electron valence-band tunneling related Lorentzian noise in fully depleted SOI MOSFETs (2003)

The behavior of the Lorentzian noise overshoot time constant /spl tau/ and plateau amplitude is investigated in fully depleted silicon-on-insulator MOSFETs with the back gate in accumulation. It is shown that /spl tau/ is identical for long-channel nand p-MOSFETs in the gate overdrive voltage range studied. For shorter lengths (L = 0.12 μm), a slight reduction of /spl tau/ for the p-MOSFETs and an increase for the short n-MOSFETs has been found. The observations will be explained by considering both the injection of majority carriers in the floating body through electron valence-band tunneling and the dynamic resistance of the source-body and gate-body junction.
QS58. Galvanotactic Closed-loop Bioelectronic System for Chronic Wound Management and Accelerated Tissue Regeneration (2022)

Purpose: Approximately thirty million people in the United States suffer from diabetes. The prevalence of diabetic foot ulcers (DFUs) in this population is 13%. There is a pressing need to develop effective therapies to treat chronic wounds robustly. Current standard of care wound dressings are passive and cannot actively respond to variations in the wound environment. Smart bandages are well positioned to address these challenges with their ability to integrate (bio)sensors for real-time monitoring and active wound care treatment. Current smart bandage technologies have demonstrated significant promise in their ability to sense physiological conditions. This includes detecting pH of the wound, temperature, oxygen, moisture, mechanical and electrical changes. To our knowledge there have not been significant advancements in incorporating sensing technologies to deliver active wound care. We believe this can be achieved using a multidisciplinary approach combining electrical and chemical engineering with the fundamentals of cellular and biomolecular processes in wound healing directed towards high resolution, in situ tissue regeneration. Methods: A flexible printed wireless stimulator was designed and fabricated to deliver directional energy across a wound gradient. Subsequently a low impedance PEDOT:PSS electrode was designed to optimize the skin and stimulator interface, producing a robust gel with tunable adhesion properties. The smart bandage was evaluated in an excisional diabetic and C57BL6/J murine wound healing model. A parabiosis model was used to evaluate circulating cell migration into the wound bed. Single cell analyses were performed to evaluate changes in cell populations as a direct result of induced electrical stimulation. In vitro validation was performed to elucidate in vivoresults. Results: Wireless electrical stimulation resulted in significantly accelerated wound closure, when compared to controls, in both a diabetic and C57BL6/J murine excisional wound healing model. Complete epidermal recovery was observed, with a thicker collagen network and increased dermal thickness. Greater neovascularization and appendage formation were observed in the treatment groups. Single cell analyses revealed higher proliferation and remodeling regulatory markers expressed across treated groups. In vitro co-culture validation experiments demonstrated accelerated proliferation, mitotic rate and tube formation when compared to controls. Conclusion: Our data demonstrates the functionality of a robust wireless interface for wound healing. This novel treatment modality will integrate AI processing components for the development of a closed-loop functional stimulator. By combining the domain expertise of nanofabrication, mechanotransduction, fibrosis and molecular/cellular analyses, we are developing a novel chronically stable and robust smart bandage that will pave the way for the next generation of palliative wound care.
Adaptive robust contour tracking of machine tool feed drive systems-a task coordinate frame approach (1997)

We show that contouring performance can be viewed as a regulation problem in a curvilinear task coordinate frame that is attached to the desired contour. By transforming the machine tool feed drive dynamics to this task coordinate frame, an adaptive robust control (ARC) law is derived to improve the contouring performance under system parameter variation and bounded disturbances. The resulting control law is in essence a time varying PID control law with built in integral anti-windup. The effectiveness of the proposed control law is demonstrated through the simulated control of an industrial CNC machine tool feed drive system.
Thermincola carboxydiphila gen. nov., sp. nov., a novel anaerobic, carboxydotrophic, hydrogenogenic bacterium from a hot spring of the Lake Baikal area (2005)

A novel anaerobic, thermophilic, alkalitolerant bacterium, strain 2204(T), was isolated from a hot spring of the Baikal Lake region. The cells of strain 2204(T) were straight rods of variable length, Gram-positive with an S-layer, motile with one to two lateral flagella, and often formed aggregates of 3-15 cells. The isolate was shown to be an obligate anaerobe oxidizing CO and producing equimolar quantities of H(2) and CO(2) according to the equation CO+H(2)O-->CO(2)+H(2). No organic substrates were used as energy sources. For lithotrophic growth on CO, 0.2 g acetate or yeast extract l(-1) was required but did not support growth in the absence of CO. Growth was observed in the temperature range 37-68 degrees C, the optimum being 55 degrees C. The pH range for growth was 6.7-9.5, the optimum pH being 8.0. The generation time under optimal conditions was 1.3 h. The DNA G+C content was 45 mol%. Penicillin, erythromycin, streptomycin, rifampicin, vancomycin and tetracycline completely inhibited both growth and CO utilization by strain 2204(T). Thus, isolate 2204(T) was found to be the first known moderately thermophilic and alkalitolerant H(2)-producing anaerobic carboxydotroph. The novel bacterium fell within the cluster of the family Peptococcaceae within the low-G+C-content Gram-positive bacteria, where it formed a separate branch. On the basis of morphological, physiological and phylogenetic features, strain 2204(T) should be assigned to a novel genus and species, for which the name Thermincola carboxydiphila gen. nov., sp. nov. is proposed. The type strain is strain 2204(T) (=DSM 17129(T)=VKM B-2283(T)=JCM 13258(T)).
On-line adaptation of neuro-prostheses with neuronal evaluation signals (2006)

Post-training administration of the centrally acting muscarinic agonist oxotremorine (50.0 microgram/kg, ip) facilitated 48-hr retention, in mice, of a one-trial step-through inhibitory avoidance response. Oxotremorine-induced memory facilitation was not prevented by the simultaneous post-training administration of the central beta-adrenoceptor antagonist propranolol (2.0 mg/kg, ip). In contrast, post-training administration of atropine (0.5 mg/kg, ip), but not methylatropine (0.5 mg/kg, ip), completely prevented the facilitatory effects of the central beta-adrenoceptor agonist clenbuterol (30.0 micrograms/kg, ip) on retention. Low subeffective doses of clenbuterol (3.0 micrograms/kg, ip) and oxotremorine (6.25 or 12.5 micrograms/kg, ip) potentiated their effects and facilitated retention when given simultaneously immediately post-training. These results suggest that clenbuterol may induce memory facilitation through an increase of the release of acetylcholine in the brain. Post-training administration of a high dose of clenbuterol (1.0 mg/kg, ip) significantly impaired retention. Clenbuterol (1.0 mg/kg, ip)-induced impairment of retention was completely prevented by simultaneous post-training administration of oxotremorine (6.25, 12.5, or 50.0 micrograms/kg, ip). The centrally acting anticholinesterase physostigmine (21.5 or 68.0 micrograms/kg, ip) partially prevented clenbuterol-induced impairment of memory. The peripherally acting anticholinesterase neostigmine (68.0 micrograms/kg, ip) modified neither retention nor the amnestic effects of clenbuterol. Considered together, these findings are consistent with the view that brain muscarinic cholinergic mechanisms are involved in both the facilitatory and impairing effect of post-training clenbuterol on the modulation of memory storage.
Development of internally-calibrated, MMIC-based millimeter-wave radiometers to enable correction of wet-tropospheric delay for coastal zone altimetry (2011)

Critical microwave component and receiver technologies are under development to reduce the risk, cost, volume, mass, and development time for a high-frequency microwave radiometer needed to enable wet-tropospheric correction in the coastal zone and over land as part of the accelerated Tier-2 NRC Decadal Survey-recommended Surface Water and Ocean Topography (SWOT) Mission. Current satellite ocean altimeters include a nadir-viewing, co-located 18-37 GHz multi-channel microwave radiometer to measure wet-tropospheric path delay. However, due to the area of the instantaneous fields of view on the surface at these frequencies, the accuracy of wet path retrievals begins to degrade at approximately 50 km from the coasts. Additional higher-frequency microwave channels added to the Jason-class radiometers on the recommended SWOT mission will improve retrievals in coastal regions since their surface footprints are about five times smaller than the lower frequency ones. Specifically, high-frequency window channels at 92, 130 and 166 GHz are optimum for wet path delay retrievals in coastal regions. New, high-sensitivity, wide-bandwidth mm-wave radiometers using both window and sounding channels show good potential for over-land wet-path delay retrievals.
X‐Ray diffraction of oriented amylose fibers. II. Structure of V amyloses (1967)

Abstract Oriented amylose fibers in the V form were prepared and subjected to x‐ray analysis. Unit cells and the probable space group of P2 1 2 1 2 1 were determined for the V anhydrous and V hydrate forms of amylose; the analysis confirms previous predictions of these structures based on x‐ray powder patterns. Chain folding in V amyloses is discussed in view of crystallographic evidence and folding experiments conducted with space‐filling models. Reported also is evidence for amylose helices having diameters intermediate between 13.0 and 13.7 A.
125,660 specimens of natural history: navigating colonial collections in the Anthropocene (2014)

In the age of the Anthropocene, the assumed division between nature and culture is radically destabilized. By taking a nineteenth century colonial collection of natural history as our point of departure, the international touring exhibition 125,660 Specimens of Natural History: Re-imagining the Practice of Collection Through Alfred R. Wallace's Malay Expedition (premier at Komunitas Salihara, Jakarta, Indonesia in 2015) develops transcultural artistic and curatorial methodologies as means to rethink traditional views on scientific knowledge production, human-nature interactions, and the future of natural history collections.
Statistical power transmission network design (1982)

A statistical planning method is developed for expanding electric power transmission networks when the bus load forecast and operating conditions are uncertain. This method seeks the minimum cost network expansion plan which guarantees a specified level of probability of supplying the uncertain substation load-demands without overloading any circuits while dispatching the generators economically under normal operating conditions and minimizes the probability of load shedding under outage conditions. The approach taken is to formulate the planning problem as a set imbedding problem which is solved using standard constrained optimization methods.
RTOG 0417: A phase II study of bevacizumab in combination with definitive radiotherapy and cisplatin chemotherapy in untreated patients with locally advanced cervical carcinoma. (2010)

5006 Background: Concurrent cisplatin-based chemoradiotherapy is the standard treatment for locally advanced cervical cancer. RTOG 0417 was a phase II studying exploring the safety and efficacy of the addition of bevacizumab to chemoradiotherapy. Methods: Eligible patients with bulky IB-IIIB disease were treated with once-weekly cisplatin (40 mg/m2) chemotherapy and standard pelvic radiotherapy and brachytherapy. Bevacizumab was administered at 10 mg/kg IV Q2 weeks for 3 cycles during chemoradiation. Treatment-related serious and other adverse event (SAE/AE) rates within the first 90 days from treatment start were determined. Treatment- related SAEs were defined as any grade ≥ 4 vaginal bleeding or thrombotic event or grade ≥ 3 arterial event, GI bleeding or bowel/bladder perforation or any grade 5 treatment-related death. Treatment-related AEs included all SAEs and grade 3 or 4 GI toxicity persistent for > 2 weeks despite medical intervention, grade 4 neutropenia or leucopenia persisting for > 7 days, febrile neutropenia, grade 3 or 4 other hematologic toxicity and grade 3 or 4 GI, renal, cardiac, pulmonary, hepatic or neurologic AEs. All adverse events were scored using the CTCAE v 3.0 criteria (MedDRA version 6.0). Results: 60 patients from 25 institutions were enrolled between 2006 and 2009 and 49 patients were evaluable (10 ineligible and 1 received no protocol treatment). The median follow-up was 10 months (min-max: 3.4-31.4 months). The median age was 45 (min-max: 22-80). Most patients were FIGO IIB (63%) and had Zubrod performance status of 0 (67%). 80% were squamous. There were no treatment-related SAEs. There were 15 (31%) protocol specified treatment-related AEs, most common were hematologic (12/15 = 80%). Conclusions: Bevacizumab in addition to standard pelvic chemoradiotherapy for locally advanced cervical cancer is feasible and safe with respect to the protocol-specified SAEs and AEs. This project was supported by RTOG grant U10 CA21661 and CCOP grant U10 CA37422 from the NCI. This publication's contents are solely the responsibility of the authors and do not necessarily represent the official views of the NCI. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Genentech
Locking conditions and stability properties for a semiconductor laser with external light injection (1985)

We present a theoretical and experimental investigation of injection locking of semiconductor lasers. The theoretical analysis takes into account the dependence of refractive index on the carrier density expressed by the linewidth enhancement factor α. Locking conditions and dynamic stability are analyzed. The nonzero value of α results in an increased locking bandwidth, where only part of the range corresponds to a dynamically stable state. Asymmetric characteristics are obtained for the locked power and phase as a function of frequency detuning between the master and slave laser. Outside the stable range, light injection gives rise to beat phenomena and intensity pulsations. The theoretical results were confirmed by experiments on 830 nm CSP lasers and 1.3 μm BH lasers. The experiments include the first measurements of locking bandwidth characteristics reported for 1.3 μm lasers. Power spectra are recorded under locked and near-locked conditions and compared with theory. The 1.3 μm lasers are found to have a better dynamic stability than 830 nm lasers. Even so, the stability problems may exclude the particular application of injection locking where phase modulation is generated for coherent transmission.
Mathematical Modeling of Patient-Specific Ventricular Assist Device Implantation to Reduce Particulate Embolization Rate to Cerebral Vessels (2014)

Stroke is the most devastating complication after ventricular assist device (VAD) implantation, with an incidence of 14%-47% despite improvements in device design and anticoagulation. This complication continues to limit the widespread implementation of VAD therapy. Patient-specific computational fluid dynamics (CFD) analysis may elucidate ways to reduce this risk. A patient-specific three-dimensional model of the aortic arch was generated from computed tomography. A 12 mm VAD outflow-graft (VAD-OG) "anastomosed" to the aorta was rendered. CFD was applied to study blood flow patterns. Particle tracks, originating from the VAD, were computed with a Lagrangian phase model and percentage of particles entering the cerebral vessels was calculated. Twelve implantation configurations of the VAD-OG and three particle sizes (2, 4, and 5 mm) were considered. Percentage of particles entering the cerebral vessels ranged from 6% for the descending aorta VAD-OG anastomosis, to 14% for the ascending aorta at 90 deg VAD-OG anastomosis. Values were significantly different among all configurations (X(2) = 3925, p < 0.0001). Shallower and more cephalad anastomoses prevented formation of zones of recirculation in the ascending aorta. In this computational model and within the range of anatomic parameters considered, the percentage of particles entering the cerebral vessels from a VAD-OG is reduced by nearly 60% by optimizing outflow-graft configuration. Ascending aorta recirculation zones, which may be thrombogenic, can also be eliminated. CFD methods coupled with patient-specific anatomy may aid in identifying the optimal location and angle for VAD-OG anastomosis to minimize stroke risk.
Energization of NTP-NDP Kinase by Acid-base Transition Leading to ATP Formation (1974)

Journal Article Energization of NTP-NDP Kinase by Acid-base Transition Leading to ATP Formation Get access Tatsuo OKU, Tatsuo OKU Division of Enzymology, Institute for Protein Research, Osaka UniversitySuita-shi, Osaka 565 Search for other works by this author on: Oxford Academic PubMed Google Scholar Kazuo HOSOI, Kazuo HOSOI Division of Enzymology, Institute for Protein Research, Osaka UniversitySuita-shi, Osaka 565 Search for other works by this author on: Oxford Academic PubMed Google Scholar Gilbu SOE, Gilbu SOE Division of Enzymology, Institute for Protein Research, Osaka UniversitySuita-shi, Osaka 565 Search for other works by this author on: Oxford Academic PubMed Google Scholar Tomisaburo KAKUNO, Tomisaburo KAKUNO Division of Enzymology, Institute for Protein Research, Osaka UniversitySuita-shi, Osaka 565 Search for other works by this author on: Oxford Academic PubMed Google Scholar Takekazu HORIO Takekazu HORIO Division of Enzymology, Institute for Protein Research, Osaka UniversitySuita-shi, Osaka 565 Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 76, Issue 1, July 1974, Pages 233–235, https://doi.org/10.1093/oxfordjournals.jbchem.a130554 Published: 01 July 1974 Article history Received: 25 April 1974 Published: 01 July 1974
Prospective, Multi-Center, Pilot Study to Evaluate Symptom Relief in Patients with Medial Knee Osteoarthritis (OA) Treated with the KineSpring® Knee Implant for Load Reduction - The SOAR Protocol (2013)

The study described here is designed as a prospective, multicenter, open-label, single-arm pilot study. Eligible subjects with symptomatic osteoarthritis of the medial compartment of the knee will be enrolled in the study and will receive the KineSpring® Knee Implant System. The study population will consist of adult patients between 25 and 80 years of age that have been diagnosed with medial knee osteoarthritis and have failed to improve after at least 6 months of conservative medical treatment. A patient is considered to have a clinically important change in OA pain and function with a minimum improvement of 20% compared to baseline measures. We will collect data on the safety and effectiveness of the KineSpring in patients with primarily unicompartmental medial knee osteoarthritis through 24 months of postoperative follow-up. These data will provide insights on the overall clinical success and safety outcome of KineSpring System.