gebhart/patrepeval huggingface dataset:
Concept of thermal modelling for hot strip rolling of magnesium (2015)

The paper introduces a concept for the reversing hot rolling of magnesium strip consisting of reheating of twin roll casted rough strip, carrying of coil from a furnace to coiler, setting down on mandrel, uncoiling, hot rolling and coiling of the magnesium strip. In the first stage the thermal models should be established. These models shall serve in the subsequent stages in order to support by developing of a roll gap model as well as model for forecasting the microstructure and material properties of the magnesium strip. Moreover, the paper represents the state of the concept development of the thermal models. Up to now, the following technological steps are implemented: reheating of the coil, transport of coil from furnace to the coiler, setting down on the mandrel and uncoiling of coil. The modelling of these models is worked out in three dimensions and are calculated numerically by using the Finite Element Method.
The Role of Cognitive and Learning Theories in Supporting Successful EHR System Implementation Training (2012)

Given persistent barriers to effective electronic health record (EHR) system implementation and use, the authors investigated implementation training practices in six organizations reputed to have ambulatory care EHR system implementation "best practices." Using the lenses of social cognitive and adult learning theories, they explored themes related to EHR implementation training using qualitative data collected through 43 key informant interviews and 6 physician focus groups conducted between February 2009 and December 2010. The authors found consistent evidence that training practices across the six organizations known for exemplary implementations were congruent with the tenets of these theoretical frameworks and highlight seven best practices for training. The authors' analyses suggest that effective training programs must move beyond technical approaches and incorporate social and cultural factors to make a difference in implementation success. Taking these findings into account may increase the likelihood of successful EHR implementation, thereby helping organizations meet "meaningful use" requirements for EHR systems.
Six Sigma: concepts, tools, and applications (2005)

Abstract Purpose – To provide a sound discussion on the Six Sigma methodology and see how it fits in with other quality initiatives. Design/methodology/approach – A conceptual paper that takes at in‐depth look at the origins, pros and cons of Six Sigma and how it relates to some of the other quality initiatives in industry. Findings – The immediate goal of Six Sigma is defect reduction. Reduced defects lead to yield improvement; higher yields improve customer satisfaction. Six Sigma defect reduction is intended to lead to cost reduction. It has a process focus and aims to highlight process improvement opportunities through systematic measurement. Six Sigma implementation can have negative consequences if applied in the wrong project. Six Sigma is a toolset, not a management system and is best used in conjunction with other more comprehensive quality standards such as the Baldrige Criteria for Performance Excellence or the European Quality Award. Research limitations/implications – This is a conceptual study and hence there are no hypotheses tested as in an empirical study. It does provide a good foundation for future research. Practical implications – A very useful source of information and impartial advice for practitioners and researchers planning to practice the Six Sigma methodology and/or understand its pros and cons. Originality/value – This paper fulfils an identified information/resources need for Six Sigma methodology. It is based on utilizing an extensive set of statistical and advanced mathematical tools, and a well‐defined methodology that produces significant results quickly. The success of this methodology within an organization has significant momentum that can only lead to fundamental organizational cultural transformation.
[Tissue polypeptide antigen in gynecological cancer]. (1985)

Serum tissue polypeptide antigen (TPA), CEA and IAP were measured simultaneously in cervical cancer, corpus cancer and ovarian cancer. TPA levels were increased (more than 110 U/1) in 39% (32/82) of the cervical cancer and in 46% (6/12) of the corpus cancer patients, respectively. In ovarian cancer, TPA levels were elevated (146 U/1 or higher) in 64% (13/22). The positive rate of CEA was somewhat lower than that of TPA and LAP levels were as high as TPA. Moreover, TPA levels were correlated in clinical course. In immunohistochemical examination, TPA was present in cancer cells and absent in normal tissue.
2,6-Dimethylaniline—hemoglobin adducts from lidocaine in humans (1994)

Lidocaine (xylocaine) is utilized for the treatment of ventricular arrhythmias which occur during cardiac surgery or myocardial infarction and as a local anesthetic. Recent data from the National Toxicology Program reported that a principal metabolite in man, 2,6-dimethylaniline, is carcinogenic in rats. In addition, the putative metabolite N-hydroxy-2,6-dimethylaniline has been reported to be mutagenic in Salmonella typhimurium TA100. N-Hydroxy metabolites of aromatic amines may be oxidized by hemoglobin to the corresponding nitroso metabolites and the nitroso may covalently bind to cysteine groups in hemoglobin as the corresponding sulfinic acid amide. Since hemoglobin binding is an indirect measure of the formation of the N-hydroxy metabolite, we have examined the possibility that lidocaine or a metabolite may similarly covalently bind to hemoglobin in rats and humans. Using a previously developed gas chromatographic-mas spectrometric assay, hemoglobin adducts of 2,6-dimethylaniline were detected covalently bound to rat hemoglobin after administration of either 2,6-dimethylaniline or lidocaine. Consistent with previously reported observations, low levels of 2,6-dimethylaniline-hemoglobin adducts were also observed in human subjects before lidocaine administration. Following administration of lidocaine, all patients had much higher levels of 2,6-dimethylaniline-hemoglobin adducts. Differences in adduct levels in patients treated with lidocaine (70-3760 mg) ranged from 93 to 636 ng/g hemoglobin. These data indicate that N-hydroxy-2,6-dimethylaniline is a metabolite of lidocaine in man.
Modifying the NH 2 and COOH Termini of Aquaporin-5: Effects on Localization in Polarized Epithelial Cells (2005)

To reengineer polarized epithelial cell functions directly in situ, or ex vivo in the fabrication of an artificial organ, it is necessary to understand mechanisms that account for polarized membrane sorting. We have used the aquaporins (AQPs), a family of homotetrameric water channel proteins, as model membrane proteins for this purpose. AQP monomers contain six transmembrane-spanning domains linked by five interconnecting loops, with the NH2 and COOH termini residing in the cytosol. AQP5 is localized in the apical membranes of several different epithelia in vivo, and in stably transfected MDCK-II cells grown as a polarized monolayer. We wished to identify a structural region(s) within rat AQP5 (rAQP5) important for apical localization, and to study the MDCK-II cell localization of rAQP5s modified in either their NH2 or COOH terminus. We show that the NH2- terminal region does not play a major role in apical localization as deletion of the NH2 terminus produced a modified rAQP5 construct (AQP5-NT(del)) that was stably expressed and localized primarily to the apical membranes of MDCK-II cells. Attachment of a FLAG epitope to the NH2 terminus of AQP5 (AQP5(flag) construct) also did not perturb apical localization. In addition, we found that the exchange of NH2-terminal regions between rAQP5 and human AQP1 (hAQP1; a nonpolarized AQP isoform) produced a modified rAQP5 construct (AQP5-1NT) and a modified hAQP1 construct (AQP1-5NT), each of which localized as the parental AQP (apically, and to both apical and basolateral membranes, respectively). In contrast, we found that deletion of the COOH terminus resulted in a modified rAQP5 construct (AQP5-CT(del)) that was unstably expressed and localized to intracellular site(s) in MDCK-II cells. Substitution of the COOH terminus of AQP1 with the COOH terminus of AQP5 also produced a construct (AQP1-5CT) transiently expressed in intracellular compartment(s). However, substitution of the COOH terminus of rAQP5 with the COOH terminus of hAQP1 produced a modified rAQP5 construct (AQP5-1CT) that was stably expressed and localized to basolateral membranes, suggesting the loss of an apical targeting/retention signal from rAQP5, the gain of a basolateral targeting/retention signal from hAQP1, or a combination of these two possibilities.
On the number of distinct autocorrelation distributions of M-ary Sidel'nikov sequences (2008)

In this paper, we enumerate the number of distinct autocorrelation distributions of M-ary Sidel'nikov sequences of given length, while we change the primitive element for generating the sequence.
Laser Surface Modification of Various Tool Steels for Improving Hardness and Corrosion Resistance (2008)

Laser surface modification of nine tool steels, namely, plastics mold steels (PMSs), high-speed steels (HSSs) and cold/hot-work steels (CHWSs), was achieved by means of a CW Nd:YAG laser. The microstructure and the phases present in the surface of the specimens were analyzed by optical microscopy, scanning-electron microscopy and X-ray diffractometry. The surface hardness of the specimens was measured using a Vickers microhardness tester. The corrosion characteristics of the laser surface-melted steels in 3.5 wt% NaCl solution at 25 oC were studied by potentiodynamic polarization technique. The microstructures of the surface of the steels were changed completely after laser surface melting. Some steels showed improved corrosion resistance compared with the conventionally hardened specimens due to dissolution of the alloying elements in solid solution. The hardness and corrosion characteristics of all the laser surface-melted specimens are strongly dependent on the amount of passivating elements in solid solution and also on the morphology of the re-precipitated carbides. Both these factors depend on the laser processing parameters and the substrate compositions.
Properties of Hydrogenated Nanoporous SiC: An Ab Initio Study (2017)

Nanoporous silicon carbide is part of the important organosilicate class of low dielectric constant alloys. We report first-principles microscopic calculations of the properties of crystalline nanoporous SiCH systems. Properties examined include the density, pore size, dielectric constant, and strain moduli. We examined the relationship between the various properties and the amount of hydrogen in the material. In addition, the bonding topology is examined. The present results are compared with a variety of experiments.
Identification of a Talin-binding Site in the Integrin β3 Subunit Distinct from the NPLY Regulatory Motif of Post-ligand Binding Functions (1999)

Following platelet aggregation, integrin alpha(IIb)beta(3) becomes associated with the platelet cytoskeleton. The conserved NPLY sequence represents a potential beta-turn motif in the beta(3) cytoplasmic tail and has been suggested to mediate the interaction of beta(3) integrins with talin. In the present study, we performed a double mutation (N744Q/P745A) in the integrin beta(3) subunit to test the functional significance of this beta-turn motif. Chinese hamster ovary cells were co-transfected with cDNA constructs encoding mutant beta(3) and wild type alpha(IIb). Cells expressing either wild type (A5) or mutant (D4) alpha(IIb)beta(3) adhered to fibrinogen; however, as opposed to control A5 cells, adherent D4 cells failed to spread, form focal adhesions, or initiate protein tyrosine phosphorylation. To investigate the role of the NPLY motif in talin binding, we examined the ability of the mutant alpha(IIb)beta(3) to interact with talin in a solid phase binding assay. Both wild type and mutant alpha(IIb)beta(3), purified by RGD affinity chromatography, bound to a similar extent to immobilized talin. Additionally, purified talin failed to interact with peptides containing the AKWDTANNPLYK sequence indicating that the talin binding domain in the integrin beta(3) subunit does not reside in the NPLY motif. In contrast, specific binding of talin to peptides containing the membrane-proximal HDRKEFAKFEEERARAK sequence of the beta(3) cytoplasmic tail was observed, and this interaction was blocked by a recombinant protein fragment corresponding to the 47-kDa N-terminal head domain of talin (rTalin-N). In addition, RGD affinity purified platelet alpha(IIb)beta(3) bound dose-dependently to immobilized rTalin-N, indicating that an integrin-binding site is present in the talin N-terminal head domain. Collectively, these studies demonstrate that the NPLY beta-turn motif regulates post-ligand binding functions of alpha(IIb)beta(3) in a manner independent of talin interaction. Moreover, talin was shown to bind through its N-terminal head domain to the membrane-proximal sequence of the beta(3) cytoplasmic tail.
Supervisory Control for High-Voltage Direct Current Transmission Systems (2017)

The growth of renewable energy production is changing the future of power transmission systems. In recent years, High-Voltage Direct Current (HVDC) technologies based on Modular Multilevel Converters (MMC) are embraced by industry and academia as a solution for the efficient integration of renewable energies into electrical grids. Faster and more complex control strategies will be needed in this domain which nowadays relies heavily on human decision. This paper proposes a Discrete Event System (DES) approach to manage the control responses to deploy in an HVDC grid. Based on Discrete Event Systems (DES) modelling and Supervisory Control Theory (SCT), this paper proposes a method for synthesizing a supervisory control for HVDC systems, which focuses on local observations and limits the number of events to be communicated. The method is validated by simulation for the start-up of a point-to-point link.
Effect of single dose resin-cathartic therapy on serum potassium concentration in patients with end-stage renal disease. (1998)

Hyperkalemia in patients with renal failure is frequently treated with a cation exchange resin (sodium polystyrene sulfonate, hereafter referred to as resin) in combination with a cathartic, but the effect of such therapy on serum potassium concentration has not been established. This study evaluates the effect of four single-dose resin-cathartic regimens and placebo on 5 different test days in six patients with chronic renal failure. Dietary intake was controlled. Fecal potassium output and serum potassium concentration were measured for 12 h. Phenolphthalein alone caused an average fecal potassium output of 54 mEq. The addition of resin caused an increase in insoluble potassium output but a decrease in soluble potassium output; therefore, there was no significant effect of resin on total potassium output. Sorbitol plus resin caused less potassium output than phenolphthalein plus resin. On placebo therapy, the average serum potassium concentration increased slightly (0.4 mEq/L) during the 12-h experiment. This rise was apparently abrogated by some of the regimens that included resin; this may have been due in part to extracellular volume expansion caused by absorption of sodium released from resin. Phenolphthalein regimens were associated with a slight rise in serum potassium concentrations (similar to placebo); this may have been due to extracellular volume contraction produced by high volume and sodium-rich diarrhea and acidosis secondary to bicarbonate losses. None of the regimens reduced serum potassium concentrations, compared with baseline levels. Because single-dose resin-cathartic therapy produces no or only trivial reductions in serum potassium concentration, and because this therapy is unpleasant and occasionally is associated with serious complications, this study questions the wisdom of its use in the management of acute hyperkalemic episodes.
Substituent effects in saturated systems. Basicity, reactivity, and stereochemistry in 3- and 6-substituted cis-hexahydrocarbazoles (1971)

Rates of quaternisation in acetonitrile and methanol, and pKa values in water and aqueous 2-butoxyethanol, have been measured for a series of N-methyl-cis-hexahydrocarbazoles substituted (But, Me-, and MeO-) at the 3- and 6-positions. The marked decrease in basicity caused by 6-t-butyl, syn-3-methyl, and syn-3-t-butyl substitution is probably due to steric inhibition of general solvation of the conjugate acid, whereas in the case of the 3,3-dimethyl derivative the effect is offset by inhibition of hydrogen bonding to the free base. For individual compounds differences in rates of quaternisation accompanying a change of solvent may be interpreted in terms of steric effects on hydrogen bonding involving the nitrogen lone pair and methanol.
Retrieval of Sea Surface Wind Fields Using Multi-Source Remote Sensing Data (2020)

Timely and accurate sea surface wind field (SSWF) information plays an important role in marine environmental monitoring, weather forecasting, and other atmospheric science studies. In this study, a piecewise linear model is proposed to retrieve SSWF information based on the combination of two different satellite sensors (a microwave scatterometer and an infrared scanning radiometer). First, the time series wind speed dataset, extracted from the HY-2A satellite, and the brightness temperature dataset, extracted from the FY-2E satellite, were matched. The piecewise linear regression model with the highest R2 was then selected as the best model to retrieve SSWF information. Finally, experiments were conducted with the Usagi, Fitow, and Nari typhoons in 2013 to evaluate accuracy. The results show that: (1) the piecewise linear model is successfully established for all typhoons with high R2 (greater than 0.61); (2) for all three cases, the root mean square error () and mean bias error (MBE) are smaller than 2.2 m/s and 1.82 m/s, which indicates that it is suitable and reliable for SSWF information retrieval; and (3) it solves the problem of the low temporal resolution of HY-2A data (12 h), and inherits the high temporal resolution of the FY-2E data (0.5 h). It can provide reliable and high temporal SSWF products.
Baxter's Homunculus: Virtual Reality Spaces for Teleoperation in\n Manufacturing (2017)

Expensive specialized systems have hampered development of telerobotic\nsystems for manufacturing systems. In this paper we demonstrate a telerobotic\nsystem which can reduce the cost of such system by leveraging commercial\nvirtual reality(VR) technology and integrating it with existing robotics\ncontrol software. The system runs on a commercial gaming engine using off the\nshelf VR hardware. This system can be deployed on multiple network\narchitectures from a wired local network to a wireless network connection over\nthe Internet. The system is based on the homunculus model of mind wherein we\nembed the user in a virtual reality control room. The control room allows for\nmultiple sensor display, dynamic mapping between the user and robot, does not\nrequire the production of duals for the robot, or its environment. The control\nroom is mapped to a space inside the robot to provide a sense of co-location\nwithin the robot. We compared our system with state of the art automation\nalgorithms for assembly tasks, showing a 100% success rate for our system\ncompared with a 66% success rate for automated systems. We demonstrate that our\nsystem can be used for pick and place, assembly, and manufacturing tasks.\n
New Acetylcholinesterase-Deficient Mutants of the Nematode Caenorhabditis elegans (1985)

We have used visual screening for a mutationally induced uncoordinated phenotype, coupled with subsequent enzymatic assay, to isolate 19 new mutations producing acetylcholinesterase (AChE) deficiencies in the nematode Caenorhabditis elegans. At least 13 of these are independent, and all fall within two genes, ace-1 X and ace-2 I, previously shown to control respectively two kinetically distinct major AChE classes, A and B. Three of the 4 new ace-1 alleles and one of the 15 new ace-2 alleles are apparently leaky; the rest are probably null. For the 3 leaky ace-1 alleles, qualitative changes in the residual class A AChE strongly support the contention that ace-1 is a structural gene. In ace-2;ace-1 mutants, marked reduction in class A and B AChE reveals a third, minor, previously unrecognized AChE class, designated C.
Towards an Efficient ML System: Unveiling a Trade-off between Task Accuracy and Engineering Efficiency in a Large-scale Car Sharing Platform (2022)

Upon the significant performance of the supervised deep neural networks, conventional procedures of developing ML system are \textit{task-centric}, which aims to maximize the task accuracy. However, we scrutinized this \textit{task-centric} ML system lacks in engineering efficiency when the ML practitioners solve multiple tasks in their domain. To resolve this problem, we propose an \textit{efficiency-centric} ML system that concatenates numerous datasets, classifiers, out-of-distribution detectors, and prediction tables existing in the practitioners' domain into a single ML pipeline. Under various image recognition tasks in the real world car-sharing platform, our study illustrates how we established the proposed system and lessons learned from this journey as follows. First, the proposed ML system accomplishes supreme engineering efficiency while achieving a competitive task accuracy. Moreover, compared to the \textit{task-centric} paradigm, we discovered that the \textit{efficiency-centric} ML system yields satisfactory prediction results on multi-labelable samples, which frequently exist in the real world. We analyze these benefits derived from the representation power, which learned broader label spaces from the concatenated dataset. Last but not least, our study elaborated how we deployed this \textit{efficiency-centric} ML system is deployed in the real world live cloud environment. Based on the proposed analogies, we highly expect that ML practitioners can utilize our study to elevate engineering efficiency in their domain.
Attack transients of free reed organ pipes (1999)

Free reed pipes in organs have fallen out of favor, because they were reputated to have a sluggish attack transient. To test this theory, the starting transients of the ‘‘Klarinette 8 ft’’ pipes were measured on the new Klais organ in the Auditorium Maximum, Bochum. Further measurements to determine the role of the wind pressure were done on the wind chest of the Klais workshop in Bonn. The transients of the free reed pipes were compared to those of bound reed pipes and diapason pipes (measured on the same organ). As the results show, the attack transient of the free reed pipes was indeed slower than that of bound reed pipes, but on the same order of that of diapason pipes. However, in contrast to the free reed pipes, diapason pipes have a noticeable broadband noise preceding the sound. In addition, there is a delay between the onset of the first-order harmonic and the onset of the higher-order harmonic in the starting transient of the free reed pipe. This effect is not usually found in the transient of diapason pipes.
Capture and ionization cross sections in 10 MeV C5+cluster-helium collisions (1997)

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