gebhart/patrepeval huggingface dataset:
Status and Perspective of Concentrating Photovoltaic Systems: the Results of the BioCPV Project and Opportunities for a Sustainable Energy Supply to Rural Areas (2016)

The present paper reports the results of the BioCPV project, a venture of six universities conceived to develop a novel integrated renewable energy system for an autonomous electrical power generation for rural electrification. Concentrating Photovoltaics (CPV) is coupled to an Anaerobic Digestion Biogas system through a smart control mechanism to maximize the efficiency and to supply electricity uninterruptedly. The excess electricity generated during the day time is used to generate hydrogen, stored using metal hydride technologies and released during evening hours as input of an electricity generator. The waste heat of the CPV is recovered and used to accelerate the biogas production. The outcomes of the research on concentrating photovoltaic technologies are resumed: two high-concentrating systems have been developed, different thermal and electrical models have been proposed and the results of innovative researches on optics, building-integration and cooling have been presented.
Endogenous Transposable Elements Associated with Virus Infection in Maize (1984)

Evidence that transposable DNA elements are ubiquitous in plants and that gross genetic instability may well provide the means for rapid evolutionary and even regulatory adaptation is rapidly accumulating. McClintock (1984) has suggested, for example, that stress in various forms might stimulate genome reorganization and the activation of transposable elements. Such a response would be analogous to, but much less specific than, the cascade of repair and recombination functions that is induced by DNA damage in Escherichia coli and is known as the SOS response. One possible source of such stress is systemic virus infection in plants. Although the symptoms of virus infection are generally not heritable, several studies have suggested that virally stressed plants may suffer unusual levels of genetic aherations. This notion is based mainly on genetic studies of virus-infected maize (Sprague et al. 1963; Sprague and McKinney 1966, 1971; Mottinger et al. 1984a) and earlier studies on...
A New Bayesian Method to Identify the Environmental Factors That Influence Recent Migration (2008)

We present a new multilocus genotype method that makes inferences about recent immigration rates and identifies the environmental factors that are more likely to explain observed gene flow patterns. It also estimates population-specific inbreeding coefficients, allele frequencies, and local population F(ST)'s and performs individual assignments. We generate synthetic data sets to determine the region of the parameter space where our method is and is not able to provide accurate estimates. Our simulation study indicates that reliable results can be obtained when the global level of genetic differentiation (F(ST)) is >1%, the number of loci is only 10, and sample sizes are of the order of 50 individuals per population. We illustrate our method by applying it to Pakistani human data, considering altitude and geographic distance as explanatory factors. Our results suggest that altitude explains better the genetic data than geographic distance. Additionally, they show that southern low-altitude populations have higher migration rates than northern high-altitude ones.
Identification of primary substrates in organo‐mineral fertilizers by means of isoelectric focusing (1999)

Abstract Organo‐mineral fertilizers (OMF) are used to improve the efficiency with which plants absorb the nutrients contained in mineral fertilizers, thanks to the properties of the fertilizer's organic component. The quality of the organic component, and hence its origin, is of primary importance for its efficient use in agriculture as a fertilizer. It is thus necessary to identify analytical techniques which are able to distinguish the primary substrates in a mixture, as well as their humification levels. In this study, isoelectric focusing was used to recognize the four primary substrates from different organo‐mineral fertilizers containing peat, leather meal, poultry manure, or dried pig slurry. The experiments gave positive results. Peat could be distinguished from leather meal, although poultry manure was not distinguishable from dried pig slurry.
Stem Cell Harvesting after Bortezomib-Based Reinduction for Myeloma Relapsing after Autologous Transplantation: Results from the British Society of Blood and Marrow Transplantation/United Kingdom Myeloma Forum Myeloma X (Intensive) Trial (2016)

The phase III British Society of Blood and Marrow Transplantation/United Kingdom Myeloma Forum Myeloma X trial (MMX) demonstrated prospectively, for the first time, superiority of salvage autologous stem cell transplantation over chemotherapy maintenance for multiple myeloma (MM) in first relapse after previous ASCT. However, many patients have stored insufficient stem cells (PBSC) for second ASCT and robust evidence for remobilization after first ASCT is lacking. We report the feasibility, safety, and efficacy of remobilization after bortezomib-doxorubicin-dexamethasone reinduction in MMX and outcomes of second ASCT with these cells. One hundred ten patients underwent ≥1 remobilization with 32 and 4, undergoing second and third attempts, respectively. Toxicities of remobilization were similar to those seen in first-line mobilization. After all attempts, 52% of those with insufficient previously stored PBSC had harvested a sufficient quantity to proceed to second ASCT. Median PBSC doses infused, neutrophil engraftment, and time to discharge after second ASCT were similar regardless of stem cell source, as were the toxicities of second ASCT. No significant differences between PBSC sources were noted in depth of response to ASCT or time to progression. Harvesting after bortezomib-doxorubicin-dexamethasone reinduction for MM at first relapse is safe and feasible and yields a reliable cell product for second ASCT. The study is registered with ClinicalTrials.gov (NCT00747877) and EudraCT (2006-005890-24).
Secure Key Throughput of Intermittent Trusted-Relay QKD Protocols (2018)

Quantum key distribution (QKD) protocols are designed to distribute secure keys between two remote parties. Current QKD systems require the presence of a trusted relay to distribute the keys over intercontinental distances, due to technological limitations. When the trusted relay is intermittently available to the end parties, as in the case of low Earth orbit (LEO) satellites, the QKD system undergoes a severe reduction in the amount of exchangeable secret bits. This paper proposes a new way to analyze the performance of QKD systems under these premises. It is shown that the secret key rate is not the most important figure of merit in the design of QKD protocols with intermittent relays, despite its importance for standard QKD links.
Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products (2015)

Covering: up to 2015. Over the centuries, microbial secondary metabolites have played a central role in the treatment of human diseases and have revolutionised the pharmaceutical industry. With the increasing number of sequenced microbial genomes revealing a plethora of novel biosynthetic genes, natural product drug discovery is entering an exciting second golden age. Here, we provide a concise overview as an introductory guide to the main methods employed to unlock or up-regulate these so called 'cryptic', 'silent' and 'orphan' gene clusters, and increase the production of the encoded natural product. With a predominant focus on bacterial natural products we will discuss the importance of the bioinformatics approach for genome mining, the use of first different and simple culturing techniques and then the application of genetic engineering to unlock the microbial treasure trove.
Restoration of atypical protein kinase C ζ function in autosomal dominant polycystic kidney disease ameliorates disease progression (2022)

Autosomal dominant polycystic kidney disease (ADPKD) affects more than 500,000 individuals in the United States alone. In most cases, ADPKD is caused by a loss-of-function mutation in the <i>PKD1</i> gene, which encodes polycystin-1 (PC1). Previous studies reported that PC1 interacts with atypical protein kinase C (aPKC). Here we show that PC1 binds to the ζ isoform of aPKC (PKCζ) and identify two PKCζ phosphorylation sites on PC1's C-terminal tail. PKCζ expression is down-regulated in patients with ADPKD and orthologous and nonorthologous PKD mouse models. We find that the US Food and Drug Administration-approved drug FTY720 restores PKCζ expression in in vitro and in vivo models of polycystic kidney disease (PKD) and this correlates with ameliorated disease progression in multiple PKD mouse models. Importantly, we show that FTY720 treatment is less effective in PKCζ null versions of these PKD mouse models, elucidating a PKCζ-specific mechanism of action that includes inhibiting STAT3 activity and cyst-lining cell proliferation. Taken together, our results reveal that PKCζ down-regulation is a hallmark of PKD and that its stabilization by FTY720 may represent a therapeutic approach to the treat the disease.
Binding of Urate and Caffeine to Haemocyanin Analysed by Isothermal Titration Calorimetry (2001)

Haemocyanin serves as an oxygen carrier in the haemolymph of decapod crustaceans. The oxygen-binding behaviour of the pigment is modulated by the two major anaerobic metabolites, l-lactate and urate. The binding of these two metabolites to haemocyanin has been investigated mainly indirectly by following the effector-induced changes in the oxygen-binding properties of the respiratory pigment. Only a few direct investigations of effector binding, employing ultracentrifugation techniques and equilibrium dialysis, have been carried out. No evidence for cooperative binding for either effector was detected using these methods. However, isothermal titration calorimetry (ITC) offers a useful tool to gain additional insight into the binding of effectors to these highly allosterically regulated macromolecules. By applying the ITC method to the fully oxygenated dodecameric haemocyanin of the lobster Homarus vulgaris, cooperativity in binding has been found for the urate analogue caffeine but not for urate itself: using urate and the urate analogue caffeine as ligands, two conformations of the oxygenated pigment were detected.
MUDIFT: Multivariate Distribution-Free Comparison of Growth Curves (1989)

Gerard E. Dallal, Shumei Guo, R. Simon, R. L. Klabansky, J. E. Talmadge, MUDIFT: Multivariate Distribution-Free Comparison of Growth Curves, The American Statistician, Vol. 43, No. 2 (May, 1989), p. 125
PM-13In Situ TEM Study on Redox Cycling of Ni-ScSZ Anode in Solid Oxide Fuel Cells (2017)

In situ observation on redox cycling of the Ni(O)-ScSZ (scandia-stabilized zirconia) anode in solid oxide fuel cells (SOFCs) has been carried out using environmental TEM (ETEM). Several in situ TEM observations on reduction of NiO nano-particles/powders have been reported [1–3]. We have investigated lamellas lifted out from the real SOFC by focused ion beam. While the Ni-ScSZ was observed under an oxygen pressure of 3 mbar, oxidation of Ni started from the surface of the grains above at 300 oC. Each Ni particle became NiO polycrystals after the temperature was elevated to 800 oC. In the case of in situ observation of NiO-ScSZ anode under a hydrogen atmosphere of 3 mbar, nano-pore generation at grain boundaries and the surface of NiO particles was observed around at 400 oC due to the volume shrinkage which accompanied NiO reduction. Furthermore, Ni densification occurred at higher temperatures than 700 oC. TEM lattice images were also taken both for the oxidation of Ni and the reduction of NiO during heating to 800 oC. This method has been applied to in situ TEM observation of reactions in the SOFC under applied electric fields.
Influence of Width on Velocities of Long Waves in Plates (1957)

Abstract This paper contains a discussion of the velocities of propagation of long flexural and extensional waves in a plate or bar in the transition region between the states of generalized plane stress and plane strain; i.e., for arbitrary width-thickness ratios (h/a) of rectangular sections. The investigations are carried out mathematically on the basis of approximate equations of motion. It is found that, for flexural waves, as h/a increases from zero, the velocity remains close to that for generalized plane stress until quite large values of h/a are reached, after which the velocity rises asymptotically toward that for plane strain. For extensional waves the velocity is slightly smaller than that for generalized plane stress for all h/a &amp;gt; 0.
Pouvoir réflecteur d'une lame diélectrique en propagation guidée application à la mesure des permittivités complexes (1969)

La détermination de la permittivité complexe est obtenue à partir de la mesure du pouvoir réflecteur d'une lame diélectrique (ou semiconductrice) placée en avant d'un court-circuit mobile. Le pouvoir réflecteur R est une fonction périodique de la distance Δ séparant le diélectrique du court-circuit et ses extremums RM et Rm ne dépendent que de la permittivité du diélectrique. La mesure de RM et Rm conduit à la détermination de ε' et ε".
Genetic Analysis of a Unique Human Immunodeficiency Virus Type 1 (HIV-1) with a Primer Binding Site Complementary to tRNA Met Supports a Role for U5-PBS Stem-Loop RNA Structures in Initiation of HIV-1 Reverse Transcription (1999)

Human immunodeficiency virus type 1 (HIV-1) exclusively uses tRNA3Lys to initiate reverse transcription. A novel HIV-1 mutant which stably utilizes tRNAMet rather than tRNA3Lys as a primer was previously identified [HXB2(Met-AC] (S.-M. Kang, Z. Zhang, and C. D. Morrow, J. Virol. 71:207-217, 1997). Comparison of RNA secondary structures of the unique sequence (U5)-primer binding site (PBS) viral RNA genome alone or complexed with tRNAMet of HXB2(Met-AC) revealed structural motifs in common with the U5-PBS of the wild-type virus. In the current study, mutations were constructed to alter the U5-PBS structure and disrupt the U5-PBS-tRNAMet interaction of the virus derived from HXB2(Met-AC). All of the mutant viruses were infectious following transfection and coculture with SupT1 cells. Analysis of the initiation of reverse transcription revealed that some of the mutants were impaired compared to HXB2(Met-AC). The genetic stability of the PBS from each virus was determined following in vitro culture. Two mutant proviral constructs, one predicted to completely disrupt the stem-loop structure in U5 and the other predicted to destabilize contact regions of U5 with tRNAMet, reverted back to contain a PBS complementary to tRNA3Lys. All other mutants maintained a PBS complementary to tRNAMet after in vitro culture, although all contained multiple nucleotide substitutions within the U5-PBS from the starting proviral clones. Most interestingly, a viral mutant containing a 32-nucleotide deletion between nucleotides 142 and 173, encompassing regions in U5 which interact with tRNAMet, maintained a PBS complementary to tRNAMet following in vitro culture. All of the proviral clones recovered from this mutant, however, contained an additional 19-nucleotide insertion in U5. RNA modeling of the U5-PBS from this mutant demonstrated that the additional mutations present in U5 following culture restored RNA structures similar to those modeled from HXB2(Met-AC). These results provide strong genetic evidence that multiple sequence and structural elements in U5 in addition to the PBS are involved in the interaction with the tRNA used for initiation of reverse transcription.
Cardiac sympathetic denervation in the prevention of genetically mediated life-threatening ventricular arrhythmias (2022)

Proper management of patients affected by genetic disorders causing life-threatening arrhythmias is important for several reasons, including even societal ones, given the predominantly young age of those affected. Incorrect management often has dire consequences, ranging from unnecessary psychologic damage for the patients whose life becomes too limited by the fear of sudden death to equally avoidable tragedies when the entire armamentarium of effective therapies is not fully utilized. In this review, we focus primarily on long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT) and deal specifically with the clinical impact of the most commonly used cardiac sympathetic denervation (CSD), namely left cardiac sympathetic denervation (LCSD). The two of us have used LCSD in the management of our patients with either LQTS or CPVT for a very long time and have been involved in ∼500 such interventions. It is on the basis of this personal and direct experience that we wish to share our views with clinical cardiologists and electrophysiologists, adult and paediatric, and with genetic cardiologists. We will begin by reviewing the history and rationale underlying sympathetic denervation therapy and will continue with a disease-specific intensification of therapy, and then with a discussion on how the impressive efficacy of LCSD should translate into guideline-directed therapy in both current and future guidelines, in order to upgrade the quality of care in the era of precision medicine.
Separation of Non-Negative Mixture of Non-Negative Sources Using a Bayesian Approach and MCMC Sampling (2006)

This paper addresses blind-source separation in the case where both the source signals and the mixing coefficients are non-negative. The problem is referred to as non-negative source separation and the main application concerns the analysis of spectrometric data sets. The separation is performed in a Bayesian framework by encoding non-negativity through the assignment of Gamma priors on the distributions of both the source signals and the mixing coefficients. A Markov chain Monte Carlo (MCMC) sampling procedure is proposed to simulate the resulting joint posterior density from which marginal posterior mean estimates of the source signals and mixing coefficients are obtained. Results obtained with synthetic and experimental spectra are used to discuss the problem of non-negative source separation and to illustrate the effectiveness of the proposed method
The genome sequence of Mycoplasma hominis and comparison with the minimal bacterial genomes of the human pathogens, M. genitalium and Ureaplasma parvum (2008)

International audience
Visualisation of geographic information in a dynamic 3-dimensional environment (2002)

For an efficient exploration of integrated remote sensing and GIS datasets of high dimensionality, virtual reality technology is likely to offer much promise in the future and is likely to become indispensable alongside developments in 3-D visualisation techniques. The aim of this study was to investigate how new and emerging technologies may be used to provide improved visualisation of geographic data and new distributed services and systems. A prototype visualisation environment was developed around multi-platform open source software tools which allows for 2- and 3-dimensional views, exploration and navigation of Earth Observation imagery and other associated geographic data such as land use maps.
Aptasensors in Health, Environment and Food Safety Monitoring (2012)

Biosensors have been developed using various types of sensing elements like biomacromolecules (viz. enzymes, antibodies, receptors, nucleic acids, etc.) organelles, tissues, intact cells of both microorganisms and higher organisms. A recent trend is the emergence of aptamers as sensing elements that has the potential to replace all the above ligands. This is possible due to the unique features of aptamers (sensitivity, specificity, reusability, stability, non-immunogenic- ity), which can be easily exploited in biosensor technology. Aptasensors are thus basically biosensors based on aptamers as ligand molecules. Here we review the various applications of aptasensors in health (specifically in diagnostics), food industry and environmental monitoring.
Systemic Arginine Depletion After a Murine Model of Surgery or Trauma (2011)

The biological consequences of arginine depletion remain incompletely understood. These data are consistent with data showing that patients given arginine-containing diets experience reduced morbidity. Understanding of arginine metabolism after ST may lead to therapies aimed at improving clinical outcome after ST.
Pramlintide: A Human Amylin Analogue Reduced Postprandial Plasma Glucose, Insulin, and C-peptide Concentrations in Patients with Type 2 Diabetes (1997)

In order to determine the influence of a 5 h infusion of pramlintide compared to placebo on postprandial glucose, lactate, insulin, and C-peptide concentrations in patients with Type 2 diabetes, a single-blind, randomized, cross-over study was conducted in 24 patients; 12 treated with exogenous insulin and 12 managed with diet and/or oral hypoglycaemic agents. One hour after initiation of infusion, patients consumed a Sustacal test meal. The protocol was repeated on the following day with each patient receiving the alternate study medication. Pramlintide infusion in the insulin-treated patients resulted in statistically significant reductions in mean glucose, insulin, C-peptide, and lactate concentrations during the 4-h period after the Sustacal test meal. Pramlintide infusion also resulted in significant reductions of mean insulin, C-peptide, and lactate concentrations, but not glucose concentrations, in the patients treated with diet and/or oral hypoglycaemic agents. Within this latter group, reduction in postprandial glucose concentrations in individual patients correlated with glycated haemoglobin values. These results suggest that administration of pramlintide may improve glycaemic control in patients with Type 2 diabetes treated with insulin or poorly controlled on diet and/or oral hypoglycaemic agents.
ChemInform Abstract: Synthesis of β‐Lactones. Part 9. Synthesis of Enantiomerically Pure β‐Lactones by the Tandem Aldol—Lactonization. A Highly Efficient Access to (3S,4S)‐3‐Hexyl‐4‐[(2S)‐2‐hydroxytridecyl]oxetan‐2‐one (IV), the Key Intermediate for the Enzyme Inhibitors Tetrahydrolipstatin (VIa) and Tetrahydroesterastin (VIb). (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ECONOMICS OF ZINC COATING SYSTEMS FOR CORROSION PROTECTION (1984)

Coating systems containing zinc offer excellent corrosion protection for steel. This paper reviews the various coating systems with zinc in their formulation and illustrates that, although in some cases their initial cost may be high, their life expectancy is long, and thus, their use is economical. There are two classes of zinc coatings: metallic zinc coatings and non-metallic zinc coatings. This paper deals primarily with the economics of two metallic zinc coatings, hot dip galvanizing and zinc-rich paints. Both of these coatings provide excellent protection for steel and have long, effective service lives before maintenance is required.
Research of WSN Node localization algorithm based on Weighted DV-HOP (2012)

The node localization algorithm is one of the key technologies in WSN. In the paper, a Weighted DV-HOP algorithm is proposed based on traditional DV-HOP algorithm. And a improving simulation model is employed to confirm the changes of localization accuracy. Comparing DV-HOP algorithm, simulation shows that the WDV-HOP algorithm can increase localization accuracy by above 2% with the same conditions which includes the percentage of anchor node, the scope of radio range and the network connectivity. Conversely, under the same accuracy request, the number of percentage of anchor node can be reduced obviously to lower the network investment cost.