gebhart/patrepeval huggingface dataset:
Formability of Al–Nb Bearing Ultra High-strength TRIP-aided Sheet Steels with Bainitic Ferrite and/or Martensite Matrix (2010)

Microstructure, tensile properties and stretch-flangeability of 980–1470 MPa grade Al or Al–Nb bearing TRIP-aided cold-rolled sheet steels with bainitic ferrite and/or martensite matrix microstructure (TBF steels) were investigated for automotive applications such as impact member reinforcements, sheet flames and so on. In addition, these properties were related with the microstructure and the retained austenite characteristics. Complex additions of 0.5% Al and 0.05% Nb into a base steel with chemical composition of 0.2% C, 1.5% Si and 1.5% Mn (in mass%) significantly enhanced the total elongation and stretch-flangeability, especially when austempered at temperatures below martensite-start temperature. The excellent stretch-flangeability was primarily associated with (i) refined prior austenitic grain by NbC precipitates and (ii) uniform fine mixed matrix microstructure of bainitic ferrite and martensite, as well as (iii) TRIP effect of metastable retained austenite.
Probing Monocarpic Senescence and Pod Development Through Manipulation of Cytokinin and Mineral Supplies in Soybean Explants (1990)

Defined solutions containing cytokinin and/or mineral nutrients were supplied in lieu of the roots through the cut stem base of soybean explants (a leaf with associated pod and subtending stem segment) in order to analyze the roles of cytokinin and mineral nutrients from the roots in pod development and foliar maintenance. In explants cut at early-mid podfill, supplying only H2O accelerated leaf senescence and pod maturation and decreased seed d. wt relative to comparable parts of intact plants. Zeatin (Z) and/or minerals not only delayed leaf yellowing and the decline in foliar chlorophyll levels and photosynthetic rates but also inhibited leaflet and petiole abscission relative to H2O controls. Even large declines in foliar assimilatory processes did not necessarily lead to abscission. Z and/or minerals also increased stomatal conductivity throughout podfill. Z showed some positive synergistic effects with minerals on leaf maintenance. Pod wall, cotyledon and radicle yellowing were delayed by Z and/or minerals but not as much as leaf senescence. Minerals only or Z +minerals prolonged seed d. wt accumulation and increased final dry seed wt to a level similar to that for intact plants. Seed growth showed a complex interrelation with pod wall and leaf f. wt and d. wt changes. A decline in cytokinin and mineral flux from the roots appears to be important for pod-induced leaf senescence; however, pod development, foliar senescence and their component processes may be affected differently. Thus, even though the explant is a physiological/nutritional module of the whole plant, it is influenced by cytokinin and minerals from the roots and therefore only semiautonomous.
A community authorization service for group collaboration (2003)

In "grids" and "collaboratories", we find distributed communities of resource providers and resource consumers, within which often complex and dynamic policies govern who can use which resources for which purpose. We propose a new approach to the representation, maintenance and enforcement of such policies that provides a scalable mechanism for specifying and enforcing these policies. Our approach allows resource providers to delegate some of the authority for maintaining fine-grained access control policies to communities, while still maintaining ultimate control over their resources. We also describe a prototype implementation of this approach and an application in a data management context.
HYDRAULIC CEMENT PREPARATION FROM LURGI SPENT SHALE (2013)

Low cost material is needed for grouting abandoned retorts.Experimental work has shown that a hydraulic cement can be produced from Lurgi spent shale by mixing it in a 1:1 weight ratio with limestone and heating one hour at 1000C.With 5% added gypsum, strengths up to 25.8 MPa are obtained.This cement could make an economical addition up to about 10% to spent shale grout mixes, or be used in ordinary cement applications.
The 102-Kilobase Unstable Region of Yersinia pestis Comprises a High-Pathogenicity Island Linked to a Pigmentation Segment Which Undergoes Internal Rearrangement (1998)

Several pathogenicity islands have recently been identified in different bacterial species, including a high-pathogenicity island (HPI) in Yersinia enterocolitica 1B. In Y. pestis, a 102-kb chromosomal fragment (pgm locus) that carries genes involved in iron acquisition and colony pigmentation can be deleted en bloc. In this study, characterization and mapping of the 102-kb region of Y. pestis 6/69 were performed to determine if this unstable region is a pathogenicity island. We found that the 102-kb region of Y. pestis is composed of two clearly distinct regions: an approximately 35-kb iron acquisition segment, which is an HPI per se, linked to an approximately 68-kb pigmentation segment. This linkage was preserved in all of the Y. pestis strains studied. However, several nonpigmented Y. pestis strains harboring an irp2 gene have been previously identified, suggesting that the pigmentation segment is independently mobile. Comparison of the physical map of the 102-kb region of these strains with that of strain 6/69 and complementation experiments were carried out to determine the genetic basis of this phenomenon. We demonstrate that several different mechanisms involving mutations and various-size deletions are responsible for the nonpigmented phenotype in the nine strains studied. However, no deletion corresponded exactly to the pigmentation segment. The 102-kb region of Y. pestis is an evolutionarily stable linkage of an HPI with a pigmentation segment in a region of the chromosome prone to rearrangement in vitro.
Surgical Timing and the Menstrual Cycle Affect Wound Healing in Young Breast Reduction Patients (2016)

Young patients undergoing bilateral reduction mammaplasty during the postovulatory phase of the menstrual cycle have an increased risk of wound healing issues and poor scarring. This may be attributable to hormonal fluxes occurring during this phase and the already high hormone levels in this population.
Milliwatt second harmonic generation in quantum cascade lasers with modal phase matching (2004)

Milliwatt second harmonic power at 4.45 µm was achieved in InP lattice-matched quantum cascade lasers with monolithically-integrated resonant nonlinear cascades and modal phase matching. The use of an InP top-cladding layer and high-reflectance coating on the laser back facet enabled high linear laser power and consequently record nonlinear power.
SOI LIGBT devices with a dual P-well implant for improved latching characteristics (2002)

The authors explore the inherent tradeoff between latching current density and threshold voltage in a typical lateral insulated-gate bipolar transistor (LIGBT), which uses a shallow implant and long drive-in to form its P-well. The latching performance of LIGBTs in silicon-on-insulator (SOI) substrates is compared to that of equivalent devices in bulk silicon. Two techniques are proposed for improving the latchup/threshold tradeoff in these SOI devices. Retrograde P-well implants are shown to yield significant improvements while adding little complexity to the fabrication process. Dual P-well implants are shown to effectively decouple the latching current from the threshold voltage, yielding LIGBTs with latching current densities over 1300 A/cm/sup 2/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Molecular Cloning and Characterization of a cDNA Encoding the Retinal ArylalkylamineN-Acetyltransferase of the Rainbow Trout, Oncorhynchus mykiss (1998)

Melatonin synthesis in the retina as well as in the pineal gland exhibits daily variations with higher levels during the dark phase of light-dark cycles. To analyze the molecular mechanism of melatonin synthesis in the retina, we have cloned, sequenced and characterized a putative cDNA for arylalkylamine N-acetyltransferase (AANAT; EC 2.3.1.87), a rate-limiting enzyme in melatonin production, from the retina of the rainbow trout (Oncorhynchus mykiss). The trout AANAT cDNA (1,585 bp) contains an open reading frame encoding 240 amino acid protein (predicted molecular weight, 27,420) that is 51-65% identical to avian and mammalian AANAT. The trout retinal AANAT protein contains motifs A and B that are conserved among the N-acetyltransferase superfamily and eight potential phosphorylation sites. Southern blot analysis demonstrated that the protein is expressed by a single copy gene. A single AANAT transcript (1.6 kb) was detected in the retina but not in the liver by Northern blot analysis. The levels of AANAT mRNA in the retina exhibited day-night changes with 3.3-fold increase at night. These results indicate that in the rainbow trout retina, the activity of AANAT and thus melatonin synthesis are regulated at least in part at the transcriptional level.
Noribogaine is a G-protein biased κ-opioid receptor agonist (2015)

Noribogaine is the long-lived human metabolite of the anti-addictive substance ibogaine. Noribogaine efficaciously reaches the brain with concentrations up to 20 μM after acute therapeutic dose of 40 mg/kg ibogaine in animals. Noribogaine displays atypical opioid-like components in vivo, anti-addictive effects and potent modulatory properties of the tolerance to opiates for which the mode of action remained uncharacterized thus far. Our binding experiments and computational simulations indicate that noribogaine may bind to the orthosteric morphinan binding site of the opioid receptors. Functional activities of noribogaine at G-protein and non G-protein pathways of the mu and kappa opioid receptors were characterized. Noribogaine was a weak mu antagonist with a functional inhibition constants (Ke) of 20 μM at the G-protein and β-arrestin signaling pathways. Conversely, noribogaine was a G-protein biased kappa agonist 75% as efficacious as dynorphin A at stimulating GDP-GTP exchange (EC50=9 μM) but only 12% as efficacious at recruiting β-arrestin, which could contribute to the lack of dysphoric effects of noribogaine. In turn, noribogaine functionally inhibited dynorphin-induced kappa β-arrestin recruitment and was more potent than its G-protein agonistic activity with an IC50 of 1 μM. This biased agonist/antagonist pharmacology is unique to noribogaine in comparison to various other ligands including ibogaine, 18-MC, nalmefene, and 6'-GNTI. We predict noribogaine to promote certain analgesic effects as well as anti-addictive effects at effective concentrations>1 μM in the brain. Because elevated levels of dynorphins are commonly observed and correlated with anxiety, dysphoric effects, and decreased dopaminergic tone, a therapeutically relevant functional inhibition bias to endogenously released dynorphins by noribogaine might be worthy of consideration for treating anxiety and substance related disorders.
Process hygiene control in beer production and dispensing (2000)

Process hygiene plays a major role in the production of high quality beer. Knowledge of microorganisms found in the brewery environment and the control of microbial fouling are both essential in the prevention of microbial spoilage of beer. The present study examined the growth of surface-attached beer spoilage organisms and the detection and elimination of microbial biofilms. Moreover, the detection and characterisation of Lactobacillus lindneri, a fastidious contaminant, was studied. Beer spoilage microorganisms, such as lactic acid and acetic acid bacteria, enterobacteria and yeasts were shown to produce biofilm on process surface materials in conditions resembling those of the brewing process. However, attachment and biofilm formation were highly strain dependent. In addition, the substrates present in the growth environment had an important role in biofilm formation. Different surface materials used in the brewing process differed in their susceptibility to biofilm formation. PTFE (polytetrafluoroethylene), NBR (nitrile butyl rubber) and Viton were less susceptible to biofilm formation than stainless steel or EPDM (ethylene propylene diene monomer rubber). However, the susceptibility varied depending on the bacteria and the conditions used in the in vitro studies. Physical deterioration resulting in reduced cleanability was observed on the gasket materials with increasing age. DEAE (diethylaminoethyl) cellulose, one of the carrier materials used in immobilized yeast reactors for secondary fermentation, promoted faster attachment and growth of contaminating L. lindneri than ceramic glass beads. Beer dispensing systems in pubs and restaurants were found to be prone to biofouling, resulting eventually in microbial contamination of draught beer and cleanability problems of the dispensing equipment.
The development of DUV chemically amplified resists (1993)

The development of deep ultraviolet (DUV) resists has necessitated the introduction of new concepts in resist materials and chemistry. Successful DUV resist systems now employ the concept of chemical amplification. This catalytic reaction leads to a substantial enhancement in the imaging dose. Another benefit of chemical amplified resists is that they allow the design of materials which can be transparent to DUV exposure wavelengths, yet they can still have high sensitivity. Commercial and prototype positive- and negative-tone resists are now readily available and these resists have been used in pilot production to make the most advanced integrated circuits with {le}0.35 {mu}m design rules. At Shipley, we have undertaken to develop both negative- and positive-tone chemically amplified resists for DUV lithography. These resists are capable of high resolution (0.3 {mu}m), fast photospeed ({le}30 mJ/sq. cm), and excellent etch resistance. This presentation will discuss the chemical and lithographic properties of the Shipley negative- and positive-tone DUV chemically amplified resists. General discussion of the importance of activation energy for the catalytic process, catalytic chain length, and environmental stability will be given.
The NEFOCAST project: Quantitative precipitation estimation based on interactive satellite terminals (2017)

In this paper we describe an algorithm to retrieve 2D rainfall fields exploiting the attenuation measurements made along satellite links. This algorithm has been developed in the framework of the project NEFOCAST, a research project funded by Tuscany region. Preliminary results show that there is a good matching between the rain rate retrieved from the satellite links’ attenuation and the rain rate measured by rain gauges and weather radar. In the future, the installation of additional devices will enable the implementation of a more sophisticated algorithm for assessing the rain rate, allowing a detailed reconstruction of the rainfall field.
Chemistry and the Los Alamos hot dry rock geothermal power project (1981)

Only a small fraction of the vast amount of energy present in hot underground rocks is extractable by conventional geothermal means which require the presence of naturally occurring steam or hot water. The Hot Dry Rock Geothermal Power Project of the Los Alamos National Laboratory uses water injection to help in getting energy out of hot rocks where little natural water is present. Some of the chemical experiments and data from this project are described.
Bovine Herpesvirus Type 1 (BHV-1) UL49.5 Luminal Domain Residues 30 to 32 Are Critical for MHC-I Down-Regulation in Virus-Infected Cells (2011)

Bovine herpesvirus type 1 (BHV-1) U L 49.5 inhibits transporter associated with antigen processing (TAP) and down-regulates cell-surface expression of major histocompatibility complex (MHC) class I molecules to promote immune evasion. We have constructed a BHV-1 U L 49.5 cytoplasmic tail (CT) null and several U L 49.5 luminal domain mutants in the backbone of wildtype BHV-1 or BHV-1 U L 49.5 CT-null viruses and determined their relative TAP mediated peptide transport inhibition and MHC-1 down-regulation properties compared with BHV-1 wt. Based on our results, the U L 49.5 luminal domain residues 30-32 and U L 49.5 CT residues, together, promote efficient TAP inhibition and MHC-I down-regulation functions. In vitro, BHV-1 U L 49.5 D30-32 CT-null virus growth property was similar to that of BHV-1 wt and like the wt U L 49.5, the mutant U L 49.5 was incorporated in the virion envelope and it formed a complex with gM in the infected cells.
A Phase 1 and pharmacokinetic study evaluating daily or weekly schedules of the humanized anti-GD2 antibody hu14.18K322A in recurrent/refractory solid tumors (2020)

Hu14.18K322A is a humanized anti-GD2 monoclonal antibody with a single point mutation that reduces complement-mediated cytotoxicity, with a maximum tolerated dose (MTD) of 60 mg/m<sup>2</sup> daily for 4 days in children with recurrent/refractory neuroblastoma. We report additional results of a Phase 1 trial to determine the MTD and safety profile of hu14.18K322A in patients with osteosarcoma, and of an alternative schedule of weekly hu14.18K322A administration in patients with neuroblastoma or osteosarcoma. Eligible patients with recurrent/refractory osteosarcoma received hu14.13K22A daily x4 every 28 days in a Phase 1 traditional 3 + 3 dose escalation design. Additional patients with osteosarcoma were then enrolled to receive hu14.18K322A once weekly for 4 weeks per course. Patients with recurrent/refractory neuroblastoma were also enrolled on the weekly schedule at 50 mg/m<sup>2</sup>/dose. Six patients with osteosarcoma treated on the daily schedule received a median of 2 (range 1-6) courses; the recommended daily dose was established as 60 mg/m<sup>2</sup>. Three patients had stable disease (SD) as best overall response. Five patients (3 neuroblastoma, 2 osteosarcoma) enrolled on the weekly schedule received a median of 1 (1-3) course; 2 achieved SD as best overall response. Pain, fever, hematologic toxicities, hyponatremia, and ocular/visual abnormalities were common toxicities among both schedules. Dose-limiting toxicities attributed to hu14.18K322A included anorexia and fatigue (n = 1). Pharmacokinetic profiles were similar between daily and weekly schedules. The recommended dose for patients with osteosarcoma receiving daily hu14.18K322A x4 is 60 mg/m<sup>2</sup>. Patients receiving the weekly schedule experienced similar pharmacokinetics and toxicity profile as the daily schedule.
ChemInform Abstract: Novel Chiral Biheteroaromatic Diphosphine Oxides for Lewis Base Activation of Lewis Acids in Enantioselective Allylation and Epoxide Opening. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Glutaric Aciduria type I and acute renal failure — Coincidence or causality? (2014)

Glutaric Aciduria type I (GA-I) is a rare organic acidemia, caused by mutations in the <i>GCDH</i> gene, and characterized by encephalopathic crises with neurological sequelae. We report herein a patient with GA-I who presented with severe acute renal failure requiring dialysis, following an acute diarrheal illness. Histopathological evaluation demonstrated acute tubular necrosis, and molecular diagnosis revealed the patient to be homozygous for a previously unreported mutation, p.E64D. As renal impairment is not part of the clinical spectrum typical to GA-I, possible associations of renal failure and the underlying inborn error of metabolism are discussed, including recent advancements made in the understanding of the renal transport of glutaric acid and its derivatives during metabolic disturbance in GA-I.
After Love (2014)

Love happens in the street, standing in the dust.-José Martí, Love in the City Ruso took long strides down the smooth cement slope of 23rd Street toward the sea.Inhaling on his Hollywood cigarette, which he preferred over the cheaper Cuban brand, he belted out the lyrics to La Charanga's latest hit."Soy Cubano, soy natural.Y eso nadie me lo quita.Porque yo traigo la razón y te regalo la verdad, lo que tengo ni se compra ni se vende.(I'm Cuban, I'm real.No one can take that away from me.I bring you the reason and give you truth: What I have can't be bought or sold.)"At the ocean, Ruso jumped on the Malecón, the thick cement wall that snaked around Havana.He shouted to a group of boys waiting to dive off the rocky shore, shivering despite the merciless August sun.Getting no response, Ruso focused on me.I had been tagging along with him for almost a month but had never asked him about his sexuality.I asked if he identifi ed as gay."Look, we in Cuba have something that is called bisexual," said Ruso. "A bisexual is someone who sleeps with both men and women.I like to have sex with women, but I like men more.Because I like both, I am bisexual."He paused again and instructed me to write down the term in my notebook."It's the same word in the United States," I told him.He looked skeptical."What is a jinetero?"I asked.The question hung in the air between us."It's a Cuban who goes with gays.They take them to a place and have sex with them for money or clothes, and rip them off by charging too much.
A HIGH-THROUGHPUT MICROFLUIDIC LIGHT CONTROLLING PLATFORM FOR BIOFUEL PRODUCING PHOTOSYNTHETIC MICROALGAE ANALYSIS (2010)

We have developed a high-throughput microalgae screening platform capable of analyzing biomass production at different light conditions with single colony resolution. Combinations of different light intensities and day-night cycles resulting in 64 light conditions for each of 64 culture compartments were implemented on a single microfluidic chip by blocking the light from a single light source with different black color dye concentrations and by switching between water and black color dye, respectively. Five microalgae colony-trapping structures in each culture compartment allowed single-colony resolution growth and biofuel-production analysis. Oil-producing microalgae, Botryococcus braunii, were successfully cultured and characterized using this screening system.
Facile Plasma‐Enhanced Deposition of Ultrathin Crosslinked Amino Acid Films for Conformal Biometallization (2009)

A novel method for the facile fabrication of conformal, ultrathin, and uniform synthetic amino acid coatings on a variety of practical surfaces by plasma-enhanced chemical vapor deposition is introduced. Tyrosine, which is utilized as an agent to reduce gold nanoparticles from solution, is sublimed into the plasma field and directly deposited on a variety of substrates to form a homogeneous, conformal, and robust polyamino acid coating in a one-step, solvent-free process. This approach is applicable to many practical surfaces and allows surface-induced biometallization while avoiding multiple wet-chemistry treatments that can damage many soft materials. Moreover, by placing a mask over the substrate during deposition, the tyrosine coating can be micropatterned. Upon its exposure to a solution of gold chloride, a network of gold nanoparticles forms on the surface, replicating the initial micropattern. This method of templated biometallization is adaptable to a variety of practical inorganic and organic substrates, such as silicon, glass, nitrocellulose, polystyrene, polydimethylsiloxane, polytetrafluoroethylene, polyethylene, and woven silk fibers. No special pretreatment is necessary, and the technique results in a rapid, conformal amino acid coating that can be utilized for further biometallization.