gebhart/patrepeval huggingface dataset:
Studies on Kuru (1961)

SummaryKuru is apparently determined by a dominant gene with incomplete expressivity producing fatal disease in childhood in homozygotes of both sexes and in adult life in heterozygous female carriers, but not usually penetrant in male carriers. This simplest genetic hypothesis which will account for the unprecedented situation which kuru presents in New Guinea has not yet been refuted by studies of genealogies in the kuru region or by other human ecological investigations. No outsiders have yet developed kuru on residence in the region. Carriers of the kuru gene must possess a distinct genetic advantage in the region, for unless such carriers were genetically more fit than non-carriers loss of the gene in nonreproducing homozygotes would have prevented its attaining its present high frequency in the society.The restricted marriage pattern with island-like isolation of small marriage pools would have led to extremely slow diffusion of a new mutant kuru gene throughout the population unless the mutation was present originally in the progenitors of an Urstamm from which at least the central subgroups of the current kuru afflicted population were derived before the near-total marriage isolation of the various groups of hamlets developed.Environmental variables and the possibilities of infectious, toxic or deficiency factors operating alone or with genetic dependence have not yet been fully excluded. However, the principal investigative approach is the biochemical investigation of intermediary metabolism of kuru patients and normal natives of the kuru region, some destined to die of kuru. Such studies should advance our understanding of kuru etiology and pathogenesis whether or not it is a solely genetically mediated disease.The problems and methods of epidemiological work in the region are discussed and the ethnic setting of kuru further elaborated. A summary of the age and sex distribution of 804 studied kuru cases is given.
The nucleotide sequence of the DNA ligase gene (CDC9) fromSaccharomyces cerevisiae: a gene which is cell-cycle regulated and induced in response to DNA damage (1985)

The &lt;unl&gt;CDC9&lt;/unl&gt; gene of &lt;unl&gt;Saccharomyces&lt;/unl&gt; &lt;unl&gt;cerevisiae&lt;/unl&gt; encodes a DNA ligase, and we have determined the nucleotide sequence of a 3.85 kb fragment of DNA which emcompasses the convergently transcribed &lt;unl&gt;CDC9&lt;/unl&gt; and &lt;unl&gt;CDC36&lt;/unl&gt; genes. S1 nuclease mapping has revealed a major 5′ end for the CDC9 mRNA, and one major and one minor site for 3′ polyadenylation. These two sites lie within the C-terminal coding region of the &lt;unl&gt;CDC36&lt;/unl&gt; gene, implying that these two genes are transcribed from overlapping sequences. An interesting structural feature of the &lt;unl&gt;CDC9&lt;/unl&gt; gene is a series of 6 hexanucleotide repeats (ATGATT) which occur within the 650 bp immediately upstream from the site of transcription initiation. These repeat elements may be implicated in the cell division cycle regulated expression of &lt;unl&gt;CDC9&lt;/unl&gt;. Comparison of the predicted amino acid sequence of the yeast DNA ligase (Mr 84,806) with the sequences of the T4 and T7 bacteriophage DNA ligases reveals little similarity except for a stretch of approximately 45 amino acids, comprising 3 short homologous segments. This region may represent an ATP-binding domain common to polynucleotide ligases.
Effect of CPPU (Forchlorofenuron) with GA3 (Gibberellic acid) on fruit set and post-harvest quality of ‘Bhagwa’ pomegranate (Punica granatum) (2019)

ISHS IV International Symposium on Pomegranate and Minor Mediterranean Fruits Effect of CPPU (Forchlorofenuron) with GA3 (Gibberellic acid) on fruit set and post-harvest quality of 'Bhagwa' pomegranate (Punica granatum)
State-of-the-art modified RNAi compounds for therapeutics. (2005)

In recent years, the recognition of non-protein coding RNAs as a functional effector of genetic expression has been highlighted by the discovery of RNA interference (RNAi). RNAi is an intracellular phenomenon that enables the eukaryotic cell to utilize double-stranded RNA molecules to silence gene expression in a sequence-specific manner. The short interfering RNA (siRNA) pathway has been intensively investigated and continues to serve as the basis for the development of potent molecular genetic tools. The power of this technology is most clearly evidenced by the fact that siRNA effector molecules can be chemically synthesized and exogenously delivered to specifically target and silence any gene of choice. This capability enables not only basic research, but also opens the door to a new therapeutic modality. Furthermore, the introduction of certain chemical modifications to siRNA effectors can produce a more robust knockdown of gene expression, hence, optimizing serum stability and increasing target specificity yet limiting the induction of cellular stress response, which are key features for in vivo delivery and successful therapeutics. This article outlines the progress in the development of differentially modified siRNA duplexes and their potential role as human therapeutics.
Pharmacology of anabolic steroids (2008)

Athletes and bodybuilders have recognized for several decades that the use of anabolic steroids can promote muscle growth and strength but it is only relatively recently that these agents are being revisited for clinical purposes. Anabolic steroids are being considered for the treatment of cachexia associated with chronic disease states, and to address loss of muscle mass in the elderly, but nevertheless their efficacy still needs to be demonstrated in terms of improved physical function and quality of life. In sport, these agents are performance enhancers, this being particularly apparent in women, although there is a high risk of virilization despite the favourable myotrophic-androgenic dissociation that many xenobiotic steroids confer. Modulation of androgen receptor expression appears to be key to partial dissociation, with consideration of both intracellular steroid metabolism and the topology of the bound androgen receptor interacting with co-activators. An anticatabolic effect, by interfering with glucocorticoid receptor expression, remains an attractive hypothesis. Behavioural changes by non-genomic and genomic pathways probably help motivate training. Anabolic steroids continue to be the most common adverse finding in sport and, although apparently rare, designer steroids have been synthesized in an attempt to circumvent the dope test. Doping with anabolic steroids can result in damage to health, as recorded meticulously in the former German Democratic Republic. Even so, it is important not to exaggerate the medical risks associated with their administration for sporting or bodybuilding purposes but to emphasize to users that an attitude of personal invulnerability to their adverse effects is certainly misguided.
CDKN1A and CDKN1B polymorphisms and risk of advanced prostate carcinoma. (2003)

A multigenic model of prostate cancer susceptibility has been proposed, in which common polymorphic variants of genes, such as the androgen and vitamin D receptor, contribute to tumorigenesis. The discovery of additional genetic factors that contribute to prostate cancer risk should provide opportunities for new approaches to the detection and treatment of this common malignancy. Herein, we examined single nucleotide polymorphic variants in the 3'-untranslated region of CDKN1A (p21(cip1)) and in codon 109 of CDKN1B (p27(kip1)) for association with advanced prostate cancer in a European-American population. Ninety-six cases and 106 controls were analyzed using PCR amplification and restriction digestion assays. CDKN1A genotype was scored as CC, CT, and TT on the basis of the digestion products. The CDKN1A genotypes CT and TT were associated with an increased risk of advanced prostate carcinoma compared with the CC genotype [odds ratio (OR), 2.24; 95% confidence interval (CI), 1.02-4.95]. The CDKN1B genotype was scored as VV, VG, or GG, again on the basis of the digestion products. The CDKN1B genotype VV was also associated with an increased risk of advanced prostate carcinoma (OR, 1.95; 95% CI, 1.09-3.47). These associations were particularly strong in those patients with androgen-independent disease [OR = 2.88 (95% CI, 1.19-6.97) and 2.11 (95% CI, 1.05-4.22) for high-risk genotypes of CDKN1A and CDKN1B, respectively]. In addition, the association of CDKN1B was particularly strong in the cohort of patients under the median age of diagnosis (OR, 2.23; 95% CI, 1.08-4.59). These results suggest that in a European-American population, CDKN1A and CDKN1B variants are associated with advanced prostate cancer. Analysis of CDKN1A and/or CDKN1B genotypes may prove useful in determining which patients are at risk for developing advanced prostate carcinoma and therefore would gain the most from aggressive screening, prophylaxis, and/or treatment.
Design and Implementation of IGBT Based High Frequency Output Cyclo-Inverter Prototype (2019)

Insulated Gate Bipolar Transistor (IGBT) based controlled power is widely used in industrial applications recently. The research scope of this paper is to design and implementation of IGBT based cyclo-inverter to produce higher output frequency than input where advanced microcontroller technique was used for the implementation of control circuit. The performance of the control circuit is tested by simulating the model on Proteus Simulations packages and the full set-up is simulated using MATLAB/ Simulink software before hardware implementation. Then a prototype is developed in the lab and tested for successful operation. Experimental results obtained from oscillographic displays are found symmetrical with the theoretical expectations and simulation results.
Plazenta praevia percreta - eine schwere Komplikation nach vorausgegangener Sectio caesarea (2003)

A 36-year-old G4P1 presented at 20 weeks gestation with vaginal bleeding. Her obstetrical history was significant for two first-trimester spontaneous abortions requiring curettage and a cesarean section. On admission placenta praevia was suspected by ultrasound. A placenta percreta was suspected by ultrasound follow-up at 30 weeks. At 33 weeks she underwent cesarean section because of serious vaginal bleeding. The profound blood loss with consecutive coagulopathy required an emergency hysterectomy and multiple blood transfusions. Placenta percreta is a rare but dramatic complication after previous cesarean section. This should be kept in mind as the rate of elective cesarean sections is rising continuously.
Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis (2007)

Mechanisms other than genetic variation may downregulate expression or function of the VEGFR2 receptor in patients with ALS.
Rigorous Uncertainty Propagation Using a Dosimetry Transfer Calibration (2018)

The process of determining the uncertainty in the neutron fluence from the measured activity of a dosimetry monitor is reviewed and the importance of treating the energy-dependent correlation is illustrated using several representative neutron fields. The process of determining the uncertainty in the neutron fluence when a transfer calibration is used is then detailed. The conversion factor, when a transfer calibration is used, has a term that has an integral over the cross section appearing in both the numerator and the denominator. This term introduces a nonlinear dependence on the cross section within the conversion factor and an explicit correlation between the terms appearing in the numerator and denominator of the conversion factor. A method for rigorously treating this nonlinear uncertainty propagation is presented. This method is based upon utilizing the covariance matrix for the cross section and utilizing a statistical sampling approach based on a Cholesky transformation of this covariance matrix. This methodology is then applied to the determination of the uncertainty from a transfer calibration for a set of nine neutron spectra based upon using the 32S(n,p)32P reaction and a transfer calibration in a 252Cf standard benchmark neutron field. A very strong correlation is found in the cross-section terms as they appear in the numerator and in the denominator. When a rigorous treatment is used to propagate the uncertainty due to the cross section for the dosimetry monitor, the uncertainty in the conversion factor is reduced by a factor of more than ten times from a worst-case approach that treats the uncertainty components in the numerator and denominator as uncorrelated. This ten times difference is also seen when the comparison is made between a rigorous treatment and a treatment of the cross-section contributions where the numerator and denominator are treated as uncorrelated (i.e., when compared to a root-mean-square approach).
The size, shape, and hydration of nonionic surfactant micelles. Triton X-100 (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe size, shape, and hydration of nonionic surfactant micelles. Triton X-100Robert J. Robson and Edward A. DennisCite this: J. Phys. Chem. 1977, 81, 11, 1075–1078Publication Date (Print):June 1, 1977Publication History Published online1 May 2002Published inissue 1 June 1977https://pubs.acs.org/doi/10.1021/j100526a010https://doi.org/10.1021/j100526a010research-articleACS PublicationsRequest reuse permissionsArticle Views3086Altmetric-Citations359LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Microwave and Radio Frequency Heating of Food Products: Fundamentals, Modeling, and Applications (2014)

Contents 1.1 Introduction .................................................................................................4 1.2 Fundamentals ...............................................................................................4
On the Capacity of the Interference Channel with a Cognitive Relay (2011)

The InterFerence Channel with a Cognitive Relay (IFC-CR) consists of the classical interference channel with two independent source-destination pairs whose communication is aided by an additional node, referred to as the cognitive relay, that has a priori knowledge of both sources' messages. This a priori message knowledge is termed cognition and idealizes the relay learning the messages of the two sources from their transmissions over a wireless channel. This paper presents new inner and outer bounds for the capacity region of the general memoryless IFC-CR that are shown to be tight for a certain class of channels. The new outer bound follows from arguments originally devised for broadcast channels among which Sato's observation that the capacity region of channels with non-cooperative receivers only depends on the channel output conditional marginal distributions. The new inner bound is shown to include all previously proposed coding schemes and it is thus the largest known achievable rate region to date. The new inner and outer bounds coincide for a subset of channel satisfying a strong interference condition. For these channels there is no loss in optimality if both destinations decode both messages. This result parallels analogous results for the classical IFC and for the cognitive IFC and is the first known capacity result for the general IFC-CR. Numerical evaluations of the proposed inner and outer bounds are presented for the Gaussian noise case.
Synthesis and self-assembly of ABC linear triblock copolymers to target CO2-responsive multicompartment micelles (2016)

A series of ABC triblock copolymers were synthesized by tailoring the block length, suggesting polymers in a narrow composition window (0.34 ≤ <italic>f</italic><sub>F</sub> ≤ 0.38) might transform from spherical micelles to multicompartment micelles upon stimulation of CO<sub>2</sub>.
Complete nonlinear model for the MRC (MOS resistive circuit) (2000)

The most significant sources of nonlinearity in the MOS resistive circuit behaviour are identified and deeply analysed in this contribution. Their influence on the MRC performance and, therefore, in the circuits containing such structure is evidenced through some examples and evaluated. Some reasonable hints about the way to minimise their undesired effects are provided.
Variable regions of antibodies to synthetic polypeptides. II. Analysis of variable region genes encoding antibodies specific for (T,G)-A--L. (1986)

Monoclonal antibodies specific for the synthetic polypeptide antigen (T,G)-A--L have been produced in two strains of mice, C57BL/10 and C3H.SW. The genes encoding the variable (V) regions of these antibodies have been studied by using the DNA hybridization technique of Southern, as well as by gene cloning and sequencing. Hybridization of DNA from 14 different cell lines with a kappa-chain probe revealed that the different cell lines used one of two different gene rearrangements to encode the recombined V region gene. There was a perfect correlation between light chain rearrangement, idiotype expression, and fine specificity. Hybridization analyses of the heavy chain revealed a more complex pattern. Seven hybridomas had the rearranged heavy chain V region genes on a 4.4 kb EcoRI restriction fragment. Others were found on restriction fragments that differed in length by several hundred base pairs. The recombined heavy chain V region genes were cloned from three different hybridoma cell lines secreting anti-(T,G)-A--L antibodies, all of which express the same idiotype and fine specificity pattern. Restriction mapping and sequencing indicate that all three utilize the same V gene, identified as the 186-2 germline gene. However, different D and J genes are used to encode each of the antibodies. In contrast to the results seen in other antigen systems, heavy chain D and J genes do not have a major influence on idiotype expression and fine specificity of antibodies to the synthetic polypeptide (T,G)-A--L.
Feasibility Study of a Structured Light System Applied to Welding Inspection Based on Articulated Coordinate Measure Machine Data (2017)

The results of visual inspection of welds in structures and machines depend on both the vision of the inspector and his/her measurement skills. The use of 3-D reconstruction technologies, as the structured light system (SLS), allows the accurate assessment of the weld bead according to the quality criteria. With the proposed procedure in this paper, the extraction of fundamental quality parameters to assess the quality of welds is possible from the 3-D model remotely obtained with the SLS. This procedure enables the extraction of metric information about the thickness and the angle deformation of the welds for each point of the weld and the results can be interpreted both quantitatively (depth map and contour plotted) and qualitatively (by means of a non-dimensional coefficient designed ad-hoc for the evaluation process). Obtained results are validated using a ground truth based on an articulated coordinate measure machine.
ChemInform Abstract: Aliphatic and Alicyclic Aldehydes: Synthesis by Hydrolysis (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
2109 Construction of the driver model for analyzing the infonnation-processing in bad driving situations (2010)

It is necessary to clarify the information-processing process in a bad driving situation and construct the tool of estimating the situation with bad awareness. In this paper, the narrow course and the obstacle avoidance course are focused on. These courses are the beginner driver's and old age driver's weak situations. Risk model is adopted because of the expression of the maneuvering in a nonlinear variable environment And die probabilistic model is introduced because of the construction and analysis of the process from processing environmental information to construct the risk model. Using this model The process from getting environmental information to steering is classified.
Derivation and Measurement of the Velocity Parameters of Hydrodynamics Oscillating System (2008)

Preliminary noteAn analytical derivation for the velocity parameters of elements of a hydrodynamic acoustic flow oscillating system, namely the liquid flow velocities, the mean values of liquid oscillation velocities and the phase velocity of acoustic wave were presented in this paper.There are also presented results of indirect measurements.The stated hydrodynamic oscillating system generates an amplify modulated high-velocity liquid flow to divide materials by water jet technology.
Prognostic Significance of Exercise-Induced Left Bundle-Branch Block (1998)

Exercise-induced LBBB independently predicts a higher risk of death and major cardiac events.