gebhart/patrepeval huggingface dataset:
Subdomain communication to increase scalability in large-scale scientific applications (2009)

This paper introduces a general-purpose communication package built on top of MPI which is aimed at improving inter-processor communications for parallel computations characterized by large numbers of messages. The current library provides a utility for such applications based on two key attributes that are: (i) explicit consideration of the neighborhood communication pattern to avoid many-to-many calls and to reduce the number of collective calls and (ii) use of non-blocking MPI functions along with message packing to reduce actual communications in number and time. The introduction of the neighborhood communications leads to substantial reductions in the data exchange cost.
Altered White Matter Integrity in the Corpus Callosum in Fibromyalgia Patients Identified by Tract‐Based Spatial Statistical Analysis (2014)

Findings of the current study demonstrated that patients with FM had disrupted WM microstructure in the body of the corpus callosum, which was associated with clinical pain intensity. Our results suggest that abnormal interhemispheric transfer might contribute to the heightened pain perception. Our findings further strengthen the hypothesis of centrally augmented pain processing in patients with FM.
Laser-induced persistent orientation of chiral molecules (2019)

We study, both classically and quantum mechanically, enantioselective orientation of gas-phase chiral molecules excited by laser fields with twisted polarization. Counterintuitively, the induced orientation, whose direction is laser controllable, does not disappear after the excitation but stays long after the end of the laser pulses. We computationally demonstrate this long-lasting orientation, using propylene oxide molecules (${\mathrm{CH}}_{3}{\mathrm{CHCH}}_{2}\mathrm{O}$, or PPO) as an example, and consider two kinds of fields with twisted polarization: a pair of delayed cross-polarized pulses and an optical centrifuge. This chiral effect opens avenues for detecting molecular chirality, measuring enantiomeric excess, and separating enantiomers with the help of inhomogeneous external fields.
BRACHIAL ARTERY RESPONSIVENESS TO ISCHEMIA AND EXERCISE. (1995)

Welsch, M. A.; Feigenbaum, M. S.; Brechue, W. F. FACSM; Pepine, C. J.; Pollock, M. L. FACSM Author Information
Influence of Under-Metal Planes on Al (1991)

This study focuses on the crystallographic effects of under-metal planes on Al(111) orientation. it has been found that Al(111) preferred orientation is strongly dependent on the crystal structure and process sequence of the under-metal, and universally determined by the difference between the spacing of Al(111) plane and under-metal planes. For the first time, it is elucidated that the formation of under-metal layer with a plane whose spacing is close to that of the Al(111) plane is the most significant criterion to realize highly reliable layered Al interconnects.
B-Type Natriuretic Peptide Is Associated with Indices of Left Ventricular Dysfunction in Healthy Subjects from the General Population: The Akershus Cardiac Examination 1950 Study (2020)

In healthy participants recruited from the general population, concentrations of BNP exhibit nonlinear associations with LV systolic function, and both low and high concentrations are associated with reduced LV systolic function. This supports the notion that natriuretic peptides are beneficial and elicit cardioprotective effects, and may have important implications for the interpretation of BNP measurements in the general population.
Electron Transfer in Electron Donor—Acceptor Ensembles Containing Porphyrins and Metalloporphyrins (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Assessing MSMEs Growth Through Rosca Involvement Using Paired t-Test and One Sample Proportion Test (2020)

Abstract In this research work, rotating savings and credit association (ROSCA) effect on the growth of micro, small and medium enterprises (MSMEs) and identification of a factor supporting the continuity of ROSCAs is studied. A well-designed questionnaire with a reliability value of 0.957 was distributed to 400 entrepreneurs in Wukari through snowball sampling technique. After validity check, 368 valid questionnaires were used for the research. Firstly, a paired t-test was applied to know if entrepreneurs achieve significant positive growth in their business before and after 5 years of joining ROSCAs. At 5% level of significance, entrepreneurs achieved significant positive growth in their businesses 5 years and above of joining ROSCAs. Secondly, a one sample proportion Z-score test was used to identify the major factor responsible for ROSCAs continuity. At 5% significance level, flexibility was identified as the major factor responsible for ROSCAs. It was concluded based on the results obtained that ROSCAs has a significant positive effect on the growth of MSMEs and ROSCAs continuity towards MSMEs growth is due to its flexibility factor in terms of operations, disbursement, seeking loans and interest rate.
On Set-oriented Numerical Methods for Global Analysis of Non-smooth Mechanical Systems (2007)

A large number of engineering systems include non-linear or even non-smooth behaviour. During development and optimisation of mechanical systems, a comprehensive dynamical analysis may be essential. Set-oriented Numerical Methods offer a new and efficient approach to global dynamical analysis without the requirement for a detailed a priori knowledge of the system dynamics. This paper shows the basic concepts behind this method and presents its application to a simple model of a vibro-impact device for ultrasonic/sonic drilling. In this drilling device an impacting mass transmits vibrational energy from a piezoelectric actuator as shock waves into a drill stem. Relative global attractors will be derived which show statistical distributions for the occurrence of all possible states. Periodic solutions can be identified parallel to the evaluation of chaotic behaviour. Thus a global understanding of the system performance can be obtained, offering new ways for model verification and system design.
Erkenntnisse aus der Verhaltensforschung für die Risikowahrnehmung und das Risikomanagement (2011)

Die ökonomische Verhaltensforschung zeigt, dass Verzerrungseffekte die Risikowahrnehmung und Entscheidungsfindung systematisch beeinflussen. Diese Effekte äussern sich in verzerrten Einschätzungen sowie in Über- respektive Unterreaktionen, die in Abweichung vom rationalen Verhalten des "Homo oeconomicus" stehen. Dieser Beitrag beleuchtet unter anderem Phänomene wie Übervertrauen in Modelle oder Kontrollillusion sowie deren Auswirkung auf die Risikowahrnehmung. Das Verständnis des individuellen und organisationalen Urteils- und Entscheidungsverhaltens ist ein wichtiger erster Schritt für das Risikomanagement von Unternehmen, um Verzerrungseffekte zu vermindern.
Progress In IR Optical Fibers (1984)

AbstractA quantitative assessment of bulk chalcogenide glass material properties was conducted for the As -S, As -Se, As- Se -Te, Ge- As -Se, and Ge -As -Te glass systems. The promising glasscandidates were subsequently drawn into optical fibers by the crucible technique, and fiberattenuation losses were measured at wavelengths of He:Ne and CO2 laser sources. H. Glass preparation and purificationGlass samples were formed in quartz ampoules which had been previously baked at approxi-mately 1000 °C for 18 hours under high vacuum, typically 2 x 10 -7 mbar. The ampoules were20 mm OD x 15 mm ID at the neck and flared out for a length of 23 cm to 27 mm OD x 24 mmID, to facilitate larger sample sizes -- typically 60 gram batches. Due to the tendency oftellerium based chalcogenides to crystallize, some difficulty was experienced in fabricat-ing Ge -As -Te glasses in the above ampoules and batch sizes. Thus, 20 gram samples of theGe -As -Te glass system were prepared in quartz ampoules with 20 mm x 15 mm neck reduced downto 11 mm x 9 mm for 17 cm length. No crystallization problems were encountered using thesesmaller diameter quartz tubes.Elemental starting materials were of 99.9999 percent purity with the exception of metal-lic arsenic which was of 99.99 percent purity. Due to oxide and water contaminants, thestarting materials were further purified by thermal or chemical etch techniques.Due to the high volatility of the oxide of arsenic (s.p. = 315 °C) relative to the metal(s.p. = 613 °C), trace oxide contaminants were removed from the metallic surface by heatingunder vacuum at 350 °C for 4 hours. Similarly, absorbed water and oxide species wereremoved from elemental sulfur and selenium by melting the elements under mechanical pump
Regulation of the uPAR/uPA system expressed on monocytes by the deactivating cytokines, IL‐4, IL‐10 and IL‐13: consequences on cell adhesion to vitronectin and fibrinogen (1998)

Urokinase (uPA) and its receptor (uPAR) have been proposed to be involved in monocyte migration by inducing degradation of matrix proteins. In addition, uPAR is also implicated in cell adhesion to the vascular wall. The adhesive function of uPAR depends on a direct interaction with vitronectin which is increased by uPA and by modification of cell surface integrin (such as CD11b-CD18) when associated to uPAR. In this study we analysed the role of three deactivating cytokines, IL-4, IL-10 and IL-13, on the surface expression of uPA, uPAR and CD11b by monocytes and their consequences on monocyte adhesion to immobilized fibrinogen and vitronectin. IL-10 induced a decrease in uPA and CD11b after 18 h incubation and a delayed decrease in uPAR which was only significant after 48 h incubation. These results may explain the decrease in monocyte adhesion, which was observed after an 18 h incubation with IL-10, on immobilized vitronectin and fibrinogen. In contrast, IL-4 and IL-13 induced a decrease in uPAR after 18 h and a significant increase in uPA both in the cell lysates and at the cell surface, as well as an increase in cell surface associated CD11b. These cytokines did not modify cell adhesiveness to vitronectin or fibrinogen despite the increase in CD11b-CD18. This could be due to the decrease in uPAR because CD11b-CD18/uPAR forms a cell adhesion complex. In addition, the increase in uPA induced by IL-4 could counterbalance the direct interaction of uPAR with vitronectin. The increase in uPA suggests that IL-4 and IL-13 could induce plaque fissuring by monocytes, whereas IL-10 may induce protection against matrix protein degradation by decreasing uPA.
Magnetic resonance imaging contrast-enhancement with superparamagnetic iron oxide nanoparticles amplifies macrophage foam cell apoptosis in human and murine atherosclerosis (2022)

Ferumoxide and ferumoxtran, but not ferumoxytol, induced apoptosis of lipid-laden macrophages in human and murine atherosclerosis, potentially impacting disease progression in patients with advanced atherosclerosis.
Measurement of binocular disparity in polarized based stereoscopic display by using digital camera (2013)

Abstract This work presents an image displacement measurement by using a box pattern and the edge spread function analysis in the polarized based stereoscopic displays. The measurement determines to identify three factors (i.e., box size, image displacement, and spatial frequency response (SFR)) from the box patterns. The polarized based stereoscopic displays might sacrifice pixels for producing 3D images, which might produce errors in the image displacement and then affect the depth perception indirectly. Based on the measurement, the errors can be quantified by using the three factors. Owing to the light leakage distorting the edge spread function to obtain an inferior SFR, exactly how light leakage affects the edge spread function can be resolved on the basis of the SFR results, especially at a frequency (1/display pixel) of 1.9 in the case of the horizontal displacement. Light leakage also induces the error of the box height in even and odd intervals of the vertical displacements more than 2 pixels and 0.5 pixels, respectively. The image displacement measurement provides a simple and comprehensive means of evaluating the optical characteristics, disparity, and sharpness of the stereoscopic displays, via the three factors.
Condrosulf<sup>&#174;</sup>: Structural Characterization, Pharmacological Activities and Mechanism of Action (2014)

Condrosulf(®) is a pharmaceutical formulation containing chondroitin sulfate (CS) as an active component possessing high quality and purity and standardized properties. CS is currently applied as a SYSADOA (Symptomatic Slow Acting Drug for Osteoarthritis) agent in Europe in the treatment of osteoarthritis (OA). Furthermore, Condrosulf(®) and pharmaceutical grade CS have also been proven to possess structure-modifying effects belonging to the S/DMOAD (structure/disease modifying anti-osteoarthritis drug) class. This review summarizes current knowledge on CS/Condrosulf(®) structure and its properties, its pharmacological activity as proved by many clinical trials and metaanalysis studies and focuses attention on its mechanisms of action in the pathophysiology of osteoarthritic joint tissues. Finally, future perspectives are discussed in connection with the possibility to apply new outcome measures, such as MRI and biomarkers, which can yield important advances in the use of Condrosulf(®) as well as the development of new drugs with different structures useful in particular for the treatment of inflammatory symptoms and able to retard the progression of arthritis.
Purification of oncolytic measles virus by cation-exchange chromatography using resin-based stationary phases (2021)

Cancer therapy with oncolytic measles virus (MV) requires high titers of pure, infectious virus particles (~108 times more particles per dose than the measles vaccine). A gentle but efficient downstream purification process is therefore essential. Here we investigated the suitability of ion-exchange chromatography for the purification of MV using resin-based stationary phases. The success of purification was evaluated based on the infectious virus yield, the ratio of infectious to total MV particles, and the quantity of major contaminants (host cell DNA and total protein). After testing different anion-exchange, cation-exchange and hybrid materials, we found that the cation-exchanger Eshmuno ® CPX (Merck) was the most promising resin. By optimizing the pH of the feed and buffers, and reducing the flow rate, we achieved a yield of 80.7% infectious MV particles while reducing the ratio of infectious to total MV particles by only 16.8%. We also removed 98.3% of the total protein and 80.5% of the host cell DNA. Although resin-based chromatography is not yet typically used for virus purification, we have developed a promising new approach to improve the efficiency of MV purification during downstream processing.
Reduced Toxicity of Intravitreally Injected Liposome-Encapsulated Cytarabine (1989)

Cytarabine has been demonstrated to be a more potent inhibitor of fibroblast proliferation than fluorouracil. It is, however, more toxic to the retina. We evaluated the ocular toxicity of liposome-encapsulated cytarabine in vitrectomized and nonvitrectomized rabbit eyes by ophthalmic and histopathologic examination. In the vitrectomized group, doses of up to 26 micrograms were nontoxic to the retina. In nonvitrectomized eyes, doses of up to 55 micrograms were nontoxic. Doses of 85 micrograms resulted in loss of ganglion cells and disorganization of photoreceptor cells. The results obtained in this study demonstrated a substantial reduction in ocular toxicity of liposome-encapsulated cytarabine, as compared with a previous study which employed free drug. By virtue of its reduced toxicity, cytarabine in a liposomal vehicle may be of value in the treatment of ocular proliferative disorders.
From the Editor-in-Chief (2002)

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Homogeneous Catalytic Hydrogenation: Dihydrocarvone (2003)

Abstract Homogeneous catalytic hydrogenation: dihydrocarvone reactant: 10 g. (0.066 mole) of carvone product: dihydrocarvone
Synthesis of Crystal-Axis-Oriented BaTiO3 and Anatase Platelike Particles by a Hydrothermal Soft Chemical Process (2001)

BaTiO3 and anatase with platelike particle morphology were prepared by using a hydrothermal soft chemical process. A layered titanate of K0.8Ti1.73Li0.27O4 with a lepidocrocite-like layered structure, which has a platelike particle morphology, was used as a precursor. In the first step, the layered titanate was treated with an acid solution to obtain an H+-form layered titanate H1.07Ti1.73O4·nH2O with a lepidocrocite-like layered structure. In the second step, the H+-form layered titanate was treated in a Ba(OH)2 solution or distilled water under mild hydrothermal conditions to transform the layered titanate to BaTiO3 or anatase. The transformation reactions were investigated by XRD and SEM analyses. There are two simultaneous mechanisms in the formation of BaTiO3 under the hydrothermal conditions. One is an in situ topotactic transformation reaction in the crystal bulk of the layered titanate, and another is a dissolution−deposition reaction on the surface of the particles. In the formation of BaTiO3, the in situ topotactic transformation reaction is predominant in the solution of low Ba(OH)2 concentration, while, in the formation of anatase, most of the reaction progressed by the in situ topotactic transformation mechanism. The platelike particles of BaTiO3 and anatase, which were prepared by this method, showed a high degree of crystal-axis orientation.
Faculty Opinions recommendation of A trehalose metabolic enzyme controls inflorescence architecture in maize. (2006)

Inflorescence branching is a major yield trait in crop plants controlled by the developmental fate of axillary shoot meristems. Variations in branching patterns lead to diversity in flower-bearing architectures (inflorescences) and affect crop yield by influencing seed number or harvesting ability. Several growth regulators such as auxins, cytokinins and carotenoid derivatives regulate branching architectures. Inflorescence branching in maize is regulated by three RAMOSA genes. Here we show that one of these genes, RAMOSA3 (RA3), encodes a trehalose-6-phosphate phosphatase expressed in discrete domains subtending axillary inflorescence meristems. Genetic and molecular data indicate that RA3 functions through the predicted transcriptional regulator RAMOSA1 (RA1). We propose that RA3 regulates inflorescence branching by modification of a sugar signal that moves into axillary meristems. Alternatively, the fact that RA3 acts upstream of RA1 supports a hypothesis that RA3 itself may have a transcriptional regulatory function. PMID: 16688177
Inhibition of Neutrophil Elastase Activity by Cinnamic Acid Derivatives from Cimicifuga racemosa (2000)

Caffeic acid, fukinolic acid as well as cimicifugic acids A, B, E and F isolated from the rhizomes of Cimicifuga racemosa (Ranunculaceae) inhibited the activity of neutrophil elastase (EC 3.4.21.37) in a dose-dependent manner. An IC50 of 93 mumol/L was determined for caffeic acid and 0.23 mumol/L for fukinolic acid. Cimicifugic acid A inhibited the enzyme with an IC50 of 2.2 mumol/L, cimicifugic acid B with 11.4 mumol/L, and cimicifugic acid F with 18 mumol/L. Cimicifugic acid E was only a very weak inhibitor.
Lung cancer-associated auto-antibodies measured using seven amino acid peptides in a diagnostic blood test for lung cancer (2010)

Autoantibody profiling is a developing approach that incorporates immune recognition of myriad aberrant cancer proteins into a single diagnostic assay. We have previously described methodology to screen T7-phage NSCLC-cDNA libraries for phage-expressed proteins recognized by NSCLC-associated antibodies, and developed a multiplex assay that has excellent ability to discriminate NSCLC from control samples. This follow-up report describes the development and testing of a diagnostic autoantibody assay that uses seven amino-acid peptides as capture proteins. A random-peptide M13-phage library was screened for proteins recognized by cancer-associated antibodies. One hundred twenty-one NSCLC case and control samples were divided into two groups for training and validation, or alternately, evaluated sequentially in a leave-one-out analysis. Candidate antibody-markers were ranked by statistical discrimination between cases and controls. Receiver-Operating-Characteristic (ROC-AUC) suggested the predictive potential of various marker combinations. A five-marker combination (AUC = 0.982) afforded 90% sensitivity and 73% specificity in a training-and-testing strategy. Leave-one-out validation provided similar class prediction. Data confirm the potential of antibody profiling to provide high levels of cancer prediction. Random peptide libraries offer a universal source of capture proteins for antibody profiling that obviates the need for tumor-specific library construction and abrogates inherent problems with tumor heterogeneity during biomarker discovery.
Silver Nanostructures: Properties, Synthesis, and Biosensor Applications (2012)

Biosensor technology has recently been witnessing momentous progress, thanks to the advent of nanoscience and especially with the realization of the great role that noble metal nanostructures can play as basic platforms. Nanosilver exhibits superior optical properties as compared to other noble metals and thus has attracted a great deal of interest in the sensors arena. Remarkable results were reported which correlate properties such as size, morphology, and composition of silver nanostructures and their biosensing performance. This chapter presents a comprehensive overview on silver nanostructures, their optical properties, synthesis and utilization in biosensor applications.
CD226 is expressed on the megakaryocytic lineage from hematopoietic stem cells/progenitor cells and involved in its polyploidization (2005)

CD226 molecules play an important role in maturation of the megakaryocytes in combination with LFA-1.
Electro-Optic Modulated Phase Array in Hexagonally Poled Lithium Niobate for Flexible Array Illuminator Device (2007)

We present an adaptive and dynamic hexagonal electro-optic phase array. The proposed device consists of a 2-dimensional hexagonal array of periodically inverted ferroelectric domains, along the z-axis, in lithium niobate crystals. The phase step is achieved via the application of an external electric field, along the z-axis, through transparent electrodes. Thanks to the electro-optic effect the phase step can changed with continuity over all the 0 to 2π by applying a variable voltage. In this way different patterns can be generated. In fact, one important property of this new proposed configuration of array iluminator is the intrinsic flexibility.
Book on C (1990)

From the Publisher:
Now in its fourth edition, A Book on C retains the features that have made it a proven best-selling tutorial and reference on the ANSI C programming language. This edition builds on the many existing strengths of the text to improve, update, and extend the coverage of C, and now includes information on transitioning to Java and C++ from C. Beginners and professional programmers alike will benefit from the numerous examples and extensive exercises developed to guide readers through each concept. Step-by-step dissections of program code illuminate the correct usage and syntax of C language constructs and reveal the underlying logic of their application. The clarity of exposition and format of the book make it an excellent reference on all aspects of C.
Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population (2020)

<i>SORL1</i> is associated with AD in the Hong Kong Chinese population. The PRS model can predict AD risk and cognitive status in this population.