gebhart/patrepeval huggingface dataset:
Binding of high molecular weight kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptor. (1997)

The urokinase receptor (uPAR) binds urokinase-type plasminogen activator (u-PA) through specific interactions with uPAR domain 1, and vitronectin through interactions with a site within uPAR domains 2 and 3. These interactions promote the expression of cell surface plasminogen activator activity and cellular adhesion to vitronectin, respectively. High molecular weight kininogen (HK) also stimulates the expression of cell surface plasminogen activator activity through its ability to serve as an acquired receptor for prekallikrein, which, after its activation, may directly activate prourokinase. Here, we report that binding of the cleaved form of HK (HKa) to human umbilical vein endothelial cells (HUVEC) is mediated through zinc-dependent interactions with uPAR. These occur through a site within uPAR domains 2 and 3, since the binding of 125 I-HKa to HUVEC is inhibited by vitronectin, anti-uPAR domain 2 and 3 antibodies and soluble, recombinant uPAR (suPAR), but not by antibody 7E3, which recognizes the chain of the endothelial cell vitronectin receptor (integrin v 3 ), or fibrinogen, another v 3 ligand. We also demonstrate the formation of a zinc-dependent complex between suPAR and HKa. Interactions of HKa with endothelial cell uPAR may underlie its ability to promote kallikrein-dependent cell surface plasmin generation, and also explain, in part, its antiadhesive properties. (
Steady state levels of factor X mRNA in liver and Hep G2 cells (1987)

In order to examine the control of human factor X biosynthesis we have molecularly cloned the cDNA and investigated the expression of the Factor X gene. A recombinant clone of approximately 1100 base pairs in length containing the sequence of factor X was identified in a lambda gt11 human liver cDNA library by screening with polyclonal antibodies. One plaque was selected and confirmed for specificity with a mixture of five factor X specific monoclonal antibodies (MoAbs). A partial nucleic acid sequence of the 5' end of the cDNA corresponded to the described amino acid sequence between residues 41 and 56 of the light chain of factor X. Northern blot analysis of RNA from human liver and the hepatoma cell line, Hep G2, identified the factor X mRNA as a single molecular species of approximately 1700 bases. Cell lines which do not secrete factor X did not contain factor X mRNA indicating restriction of transcription to hepatocytes. Slot-blot hybridization analysis of factor X and actin mRNA demonstrated no change in the levels of total or specific factor X mRNA in Hep G2 cells following treatment with warfarin or vitamin K. We conclude that modulation of factor X production by these drugs, known to influence gamma-carboxylation and total factor X secretion by these cells, is mediated by changes in posttranscriptional events rather than by effects on the steady state levels of factor X mRNA.
Augmentation and impulsive behaviors in restless legs syndrome: Coexistence or association? (2016)

Editors' Note: In WriteClick this week, Dr. Nirenberg responds to “Augmentation and impulsive behaviors in restless legs syndrome: Coexistence or association?” with the hypothesis that augmentation in restless legs syndrome may be a forme fruste of dopamine agonist withdrawal syndrome. Authors Djamshidian et al. report no association between augmentation and medication nonadherence, but agree with monitoring these patients closely for addictive behaviors. In reference to “Spatial-temporal functional mapping of language at the bedside with electrocorticography,” Drs. Babajani-Feremi et al. and authors Wang et al. discuss the use of high-gamma …
Polyglycolic acid‐collagen tube combined with collagen‐binding basic fibroblast growth factor accelerates gait recovery in a rat sciatic nerve critical‐size defect model (2019)

Several nerve conduits have been investigated for their potential as alternative sources of autografts for bridging neural gaps. However, autologous nerve transplants remain the most effective for nerve repair. We examined clinically approved nerve conduits containing collagen and polyglycolic acid (PGA-c) combined with collagen-binding basic fibroblast growth factor (bFGF) containing a polycystic kidney disease (PKD) domain and collagen binding domain (CBD) (bFGF-PKD-CBD) in a rat 15-mm sciatic nerve critical-size defect model. The treatment groups were: PGA-c immersed in phosphate-buffered saline (PBS) (PGA-c/PBS group), bFGF (PGA-c/bFGF group), or bFGF-PKD-CBD (PGA-c/bFGF-PKD-CBD group), and no treatment (Defect group). Gait and histological analyses were performed. Four weeks after treatment, the recovery rate of the paw print area was significantly greater in the PGA-c/bFGFPKD-CBD group than the PGA-c/PBS and PGA-c/bFGF groups. Mean intensity of paw prints was significantly greater in the PGA-c/bFGF-PKD-CBD group than the PGA-c/PBS and Defect groups. Swing time was significantly greater in the PGA-c/PBS, PGA-c/bFGF, and PGA-c/bFGF-PKD-CBD groups than the Defect group. At 8 weeks, all three parameters were significantly greater in the PGA-c/PBS, PGA-c/bFGF, and PGA-c/bFGF-PKD-CBD groups than the Defect group. Regenerated myelinated fibers were observed in 7/8 (87.5%) rats in the PGA-c/bFGF-PKD-CBD group after 8 weeks, and in 1/8 (12.5%) and 3/8 (37.5%) rats in the PGA-c/PBS and PGA-c/bFGF groups, respectively. PGA-c/bFGF-PKD-CBD composites may be promising biomaterials for promoting functional recovery of long-distance peripheral nerve defects in clinical practice.
Amended Safety Assessment ofHypericum Perforatum-Derived Ingredients as Used in Cosmetics (2014)

The Cosmetic Ingredient Review Expert Panel (Panel) has issued an amended safety assessment of 7 Hypericum perforatum-derived ingredients as used in cosmetics. A common name for this plant is St John wort. These ingredients function in cosmetics as skin-conditioning agents-miscellaneous and antimicrobial agents. The Panel reviewed relevant animal and human data related to the H perforatum-derived ingredients. Because formulators may use more than 1 botanical ingredient in a formulation, caution was urged to avoid levels of toxicological concern for constituent chemicals and impurities. The Panel concluded that H perforatum-derived ingredients were safe as cosmetic ingredients in the practices of use and concentration as described in this safety assessment.
Origin of exchange decoupling effects in high-coercivity air-annealed CoPd multilayers (2005)

We have achieved excellent exchange decoupling of grains in CoPd multilayers by annealing in air at 300°C. Samples exhibit a slope in the hysteresis loop close to 1.0, nucleation fields as large as 11kOe, and coercivities as large as 16kOe. These are among the best properties ever achieved for CoPd multilayers. In samples of the general type seed layer\(0.3nmCo\1nmPd)×15\capping layer, it appears that atoms diffuse rapidly up and down the grain boundaries at 300°C. From x-ray photoelectron and Auger depth profiling, we have found that when Co atoms arrive at the surface they become oxidized and remain at the surface, leaving the grain boundaries depleted in Co and apparently nonmagnetic. If the annealing is carried out in vacuum, exchange decoupling of the grains does not occur. This result supports our conclusion that the presence of oxygen plays a crucial role. When Au or Pt atoms are present in the seed layer or capping layer, they diffuse into the CoPd grain boundaries and apparently enhance the exchange decoupling of grains.
On the integer sets with the same representation functions (2021)

Let $\mathbb{N}$ be the set of all nonnegative integers. For $S\subseteq \mathbb{N}$ and $n\in \mathbb{N}$, let $R_S(n)$ denote the number of solutions of the equation $n=s_1+s_2$, $s_1,s_2\in S$ and $s_1
Quantitation Over Time of Tomato Yellow Leaf Curl Geminivirus DNA in Its Whitefly Vector (1997)

ABSTRACT The amount of tomato yellow leaf curl geminivirus (TYLCV) DNA that accumulated in the vector Bemisia tabaci was studied by quantitative chemiluminescent dot-blot assay, using digoxigenin-labeled specific DNA probes. Large groups of female whiteflies were allowed to feed for 4, 12, 24, or 48 h on TYLCV-infected tomato plants and then were transferred to TYLCV-immune cucumber plants. Insects were sampled at different times during and after acquisition access and tested for TYLCV-DNA content. TYLCV-DNA assays were done either on whole insects oron the head plus prothorax (to include salivary glands) and abdomen separately. The maximum amount of TYLCV DNA, averaging from 0.5 to 1.6 ng per insect, was always attained at the end of the acquisition period. The mean amount then decreased by about 1 to 2% per day, remaining clearly detectable up to 20 days after the end of the acquisition period. Only some whiteflies that were TYLCV-positive in the abdomen were positive for head plus prothorax. In both parts of the body, TYLCV DNA remained detectable up to 18 days after the end of the acquisition period, showing that TYLCV DNA remains in insect tissues much longer than infectivity indicates.
Simultaneous Probing of the Fe and Co Sites in the CO2-Absorber Perovskite Sr0.95Ca0.05Co0.5Fe0.5O3-δ:  a Mössbauer Study (2002)

The Co and Fe sites have been probed in pristine and CO2-treated Sr0.95Ca0.05Fe0.5Co0.5O3-δ using emission (EMS) and transmission (TMS) Mössbauer spectroscopy and found to have different local oxygen coordination environments and, most probably, a layered arrangement in the lattice. The EMS and TMS spectra of the pristine material could be evaluated with a three-doublet model, with only one of the doublets being different in the two cases. The doublets were assigned to Fe species with localized and delocalized electronic states. Absorption of CO2 at 650 °C resulted in magnetic ordering, which appeared to be static in EMS and rather dynamic in TMS spectra. This difference was attributed to the lower average oxygen coordination number of Co, and therefore ready absorption of CO2 at O vacancies. CO2 treatment at 950 °C triggered partial phase separation, confirmed also by scanning electron microscopy and X-ray microanalysis measurements. It was concluded that absorption of CO2 occurs preferentially in Co-rich regions, where the oxygen vacancy concentration is higher. The Mössbauer data indicated a lower average valence state of Fe/Co atoms in the Co-rich region.
Top-interface-controlled switching and fatigue endurance of (Pb,La)(Zr,Ti)O3 ferroelectric capacitors (1999)

Mechanisms of polarization switching and fatigue in (Pb,La)(Zr,Ti)O3 (PLZT) films are studied by comparative analysis of degradation and leakage conduction of PLZT capacitors with Pt, SrRuO3 (SRO), and layered Pt/SRO (80/5 nm) electrodes. It is found that the asymmetrical Pt/SRO/PLZT/Pt structure exhibits a good fatigue performance in combination with low leakage like that on identically processed Pt/PLZT/Pt capacitor. This asymmetrical structure exhibits very unusual dependence of the endurance of switching polarization on the driving alternating-current (ac) electric field amplitude. Specifically, for high ac electric field amplitude it shows good switching endurance similar to SRO/PLZT/SRO capacitors, whereas for amplitude lower than 80 kV/cm a pronounced polarization fatigue similar to that of the conventional Pt/PLZT/Pt capacitors is observed. Based on the analysis of our results on fatigue and leakage conduction we conclude that: (i) In asymmetrical Pt/SRO/PLZT/Pt system the physical mechanisms of polarization switching vary depending on the driving voltage amplitude. The polarization switching endurance under high-amplitude cycling is governed only by the top SRO interface, whereas the degradation properties of the bottom Pt interface do not play any role. On the contrary, for driving voltage amplitudes lower than 80 kV/cm the bottom Pt-interface degradation is a limiting factor for the fatigue performance. (ii) The fatigue in PZT films is controlled by a mechanism related to the inhibition of near-by-electrode nucleation of opposite domains, as suggested earlier.
Non-static Quantum Bit Commitment (2009)

Quantum bit commitment has been known to be impossible by the independent proofs of Mayers, and Lo and Chau, under the assumption that the whole quantum states right before the unveiling phase are static to users. We here provide an unconditionally secure non-static quantum bit commitment protocol with a trusted third party, which is not directly involved in any communications between users and can be limited not to get any information of commitment without being detected by users. We also prove that our quantum bit commitment protocol is not secure without the help of the trusted third party. The proof is basically different from the Mayers-Lo-Chau's no-go theorem, because we do not assume the staticity of the finally shared quantum states between users.
An Implementation of Program Counter Encoding with TPM (2011)

Program counter encoding is a method that can prevent code pointer attacks as yet unknown including the stack smashing. Program counter encoding enforces encoding code pointer values when they are stored and decoding when they are loaded into the program counter. Safety of the key values and storage used for encoding code pointers determines the trustworthiness of program counter encoding. This paper presents and evaluates an implementation of program counter encoding with TPM (Trusted Platform Module) to reinforce the trustworthiness of the keys for program counter encoding. Simulated attacks against return addresses on stack and heap area confirmed defensive capability of program counter encoding. Performance of our implementation shows 3% overhead in SPEC CPU2006. The suggested implementation is based on the considerations of both performance and trustworthiness.
Urea Determination in Dialysis, based on a Differential pH Technique (1987)

The application of a new technique, based on differential measurements of pH, to determine urea concentration in patients of a dialysis center, is reported. Urea in plasma, whole blood or dialysis fluids is measured by an enzymatic reaction, with urease; the procedure, requiring 10 microL of sample, is simple, fast and correlates well with a reference spectrophotometric method, in the 0-300 mg/dL concentration range, according to the equation y = 1.0291 X -0.0777; r = 0.9991; n = 73.
Transforming growth factor-beta 1 is a negative regulator for differentiated thyroid cancer: studies of growth, migration, invasion, and adhesion of cultured follicular and papillary thyroid cancer cell lines. (1994)

Invasion and metastasis may be caused by the escape of tumor cells from the negative control of growth factors. We analyzed the effects of transforming growth factor-beta 1 (TGF beta 1) on growth, migration, invasion, and adhesion in three follicular thyroid cancer cell lines (FTC133, primary; FTC236, lymph node metastasis; FTC238, lung metastasis) from one patient and in a papillary line (PTC-UC3). Cell growth was measured by dimethylthiazol-diphenyltetrazolium bromide assays, and migration (basal or epidermal growth factor stimulated) was determined by the ability of cells to penetrate 8-microns pore membranes that were covered with Matrigel for invasion assays. Moreover, we studied tumor cell adhesion to collagen type IV, fibronectin, and laminin. TGF beta 1 inhibited growth in FTC (FTC133, by 31%; FTC236, 15%; FTC238, 17%; P < 0.008), but not in PTC. Migration was inhibited in all cell lines. TGF beta 1 inhibited epidermal growth factor-stimulated migration of FTC133 by 43% vs. 29% without epidermal growth factor (P < 0.03). TGF beta 1 also inhibited invasion (FTC133, 32%; FTC236, 18%; FTC238, 16%; PTC-UC3, 32%; P < 0.02). All cell lines adhered preferably to collagen type IV and fibronectin. TGF beta 1 enhanced adhesion. Again, these effects were less pronounced in the FTC metastases. In conclusion, TGF beta 1 inhibits the growth, migration, and invasion of thyroid cancer cells in vitro. It enhances adhesion to components of the extracellular matrix. Metastatic thyroid tumors may be less responsive to the negative regulation of TGF beta 1.
The Inhibitory Effect of Non-Substrate and Substrate DNA on the Ligation and Self-Adenylylation Reactions Catalyzed by T4 DNA Ligase (2016)

DNA ligases are essential both to in vivo replication, repair and recombination processes, and in vitro molecular biology protocols. Prior characterization of DNA ligases through gel shift assays has shown the presence of a nick site to be essential for tight binding between the enzyme and its dsDNA substrate, with no interaction evident on dsDNA lacking a nick. In the current study, we observed a significant substrate inhibition effect, as well as the inhibition of both the self-adenylylation and nick-sealing steps of T4 DNA ligase by non-nicked, non-substrate dsDNA. Inhibition by non-substrate DNA was dependent only on the total DNA concentration rather than the structure; with 1 μg/mL of 40-mers, 75-mers, or circular plasmid DNA all inhibiting ligation equally. A >15-fold reduction in T4 DNA ligase self-adenylylation rate when in the presence of high non-nicked dsDNA concentrations was observed. Finally, EMSAs were utilized to demonstrate that non-substrate dsDNA can compete with nicked dsDNA substrates for enzyme binding. Based upon these data, we hypothesize the inhibition of T4 DNA ligase by non-nicked dsDNA is direct evidence for a two-step nick-binding mechanism, with an initial, nick-independent, transient dsDNA-binding event preceding a transition to a stable binding complex in the presence of a nick site.
DC assisted bipolar switched reluctance machine (2015)

In this paper, a sinusoidally excited four-phase switched reluctance machine (SRM) with modified DC assisted windings is presented. The proposed four-phase SRM configuration with modified DC windings has reduced number of controllable phases and power converter devices. The DC winding configuration is modified from its traditional form by taking advantage of the machine's inherent 90 degree phase shift between adjacent phases to achieve the desired simplification in the drive. Different power electronic converters that can be used with the proposed winding configuration have also been investigated. The proposed concepts are then verified through coupled FEA circuit simulations on a case study motor.
Effects of glass fibers on the properties of micro molded plastic parts (2011)

Glass fibers are used to reinforce plastics and to improve their mechanical properties. But plastic filled with glass fibers is a concern for molding of micro scale plastic parts. The aim of this paper is to investigate the effects of glass fiber on the replication quality and mechanical properties of polymeric thin ribs. It investigates the effect of feature size and gate location on distribution of glass fibers inside the molded parts. The results from this work indicate that glass filled plastic materials have poor replication quality and nonhomogeneous mechanical properties due to the nonuniform distribution and orientation of glass fibers.
Priority Integration for Weighted Combinatorial Testing (2015)

Priorities (weights) for parameter values can improve the effectiveness of combinatorial testing. Previous approaches have employed weights to derive high-priority test cases either earlier or more frequently. Our approach integrates these order-focused and frequency-focused prioritizations. We show that our priority integration realizes a small test suite providing high-priority test cases early and frequently in a good balance. We also propose two algorithms that apply our priority integration to existing combinatorial test generation algorithms. Experimental results using numerous test models show that our approach improves the existing approaches w.r.t. Order-focused and frequency-focused metrics, while overheads in the size and generation time of test suites are small.
Doppler Global Velocimetry, ranges of accessible velocities, part I: Theory (2016)

International audience
Optimization of an ECR Thruster using Two Frequency and Pulsed Waveforms (2021)

View Video Presentation: https://doi.org/10.2514/6.2021-3382.vid The performance of an ECR magnetic nozzle thruster is optimized using custom waveforms. Single frequency, two-frequency, and pulsed microwave inputs are investigated. Performance is measured for single and two-frequency heating using a sub-millinewton thrust stand. A total of 245 points are tested using an automated global optimization algorithm. Holding forward power and flow rate constant at 30 W and 1 sccm xenon, it is found that thruster efficiency varies from 4.2% to 9.9% using single frequency heating over the range of 1050-2500 MHz. Adding a second frequency is not found to significantly affect performance. The results are discussed in the context of thruster physics and future thruster design.
Automating the Design and Construction of Query Forms (2006)

One of the simplest ways to query a database is through a form, where a user can fill in relevant information and obtain desired results by submitting the form. Designing good static forms is a non-trivial manual task, and the designer needs a sound understanding of both the data organization and the querying needs. Furthermore, form design has two conflicting goals: forms should be simple to understand, and at the same time must provide the broadest possible querying capability to the user. In this paper, we present a framework for generating forms in an automatic and principled way, given the database schema and a sample query workload. We design a tunable clustering algorithm for establishing form structure based on multiple "similar"queries, which includes a mechanism for extending form structure to support other "similar" queries the system may see in the future. The algorithm is adaptive and can incrementally adjust the form structure to reflect the addition or removal of queries in the workload. We have implemented our form generation system on a real database and evaluated it on a comprehensive set of query loads and database schemas. We observe that our system can significantly reduce the numbers of forms needed for various query loads by exploiting similarities across queries, even after placing a strict bound on form complexity.
VEGF T-1498C polymorphism, a predictive marker of differentiation of colorectal adenocarcinomas in Japanese (2008)

VEGF T-1498C polymorphism is also a candidate marker predictive of poorly-differentiated colorectal adenocarcinomas, but further investigations with a large number of patients should be addressed to draw a conclusion.