gebhart/patrepeval huggingface dataset:
Phenotyping approaches for physiological breeding and gene discovery in wheat (2009)

Abstract Conceptual models of drought‐adaptive traits have been used in breeding to accumulate complementary physiological traits (PT) in selected progeny, resulting in distribution of advanced lines to rain‐fed environments worldwide by the International Maize and Wheat Improvement Center (CIMMYT). Key steps in PT breeding at CIMMYT include characterisation of crossing block lines for stress adaptive mechanisms, strategic crossing among parents that encompass as many target traits as possible and early generation selection (EGS) of bulks for canopy temperature (CT). The approach has been successful using both elite × elite crosses as well as three way crosses involving stress adapted landraces. Other EGS techniques that are amenable to high throughput include measurement of spectral reflectance indices and stomatal aperture‐related traits. Their genetic‐ and cost‐effectiveness are supported by realisation of genetic yield gains in response to trait selection, and by economic analysis, respectively. Continual reselection within restricted gene pools is likely to lead to diminishing returns, however, exotic parents can be used to introduce new allelic diversity. Examples include landraces from the primary gene pool , and products of inter‐specific hybridisation with the secondary gene pool consisting of closely related wheat genomes. Both approaches have been successful in introducing stress‐adaptive traits. The main problem with knowing which genetic resource to use in wide‐crossing is the uncertainty with which phenotypic expression can be extrapolated from one genome/genepool to another because of their unimproved or undomesticated genetic backgrounds. Nonetheless, their PT expression can be measured and used as a basis for investing in crossing or wide crossing. Discovering the genetic basis of PT is highly complex because putative QTLs may interact with environment and genetic background, including genes of major effect. Detection of QTLs was improved in mapping populations where flowering time was controlled, while new mapping populations have been designed by screening potential parents that do not contrast in the Rht, Ppd and Vrn alleles. Association genetics mapping is another approach that can be employed for gene discovery using exclusively agronomically improved material, thereby minimising the probability of identifying yield QTLs whose alleles have been already improved by conventional breeding.
Wideband profiles of stimulus-frequency otoacoustic emissions in humans (2015)

Behavioral pure-tone hearing thresholds and stimulus-frequency otoacoustic emissions (SFOAEs) were measured with a high frequency resolution from 0.5-20 kHz in 15 female participants. Stimuli were calibrated in terms of forward pressure level (FPL). SFOAE responses to 36 dB FPL probes were largest near 1 kHz and declined above 8-10 kHz, though were still measurable at frequencies approaching 16 kHz in some ears. SFOAEs typically dropped in amplitude at a frequency that was roughly one octave below the "corner" frequency of the audiogram, and one-third to one-half of an octave below the frequency where thresholds departed from highly sensitive hearing. High-frequency SFOAE responses are likely limited by a reduction in the efficiency of the underlying generation mechanism and/or a diminished region of generation as the stimulus-driven excitation approaches the basal-most portion of the cochlea.
C2 information quality: An enterprise systems perspective (2012)

With the advent of the Information Age and the continued development of information and communications technologies (ICT), individuals and organizations have had to manage a transition from a world characterized by the paucity of information to one marked by a deluge of information. The information-related quality metrics that have been developed and used measure both absolute characteristics and “fitness for use.” The absolute measures relate to inherent aspects of a particular piece of data or information while the fitness-for-use measures generally consider the context of a single information consumer. Command and Control (C2) in the 21 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> century relies increasingly on decentralized and distributed networks. As a result, data and information quality needs to be considered from a systems or networked-enterprise perspective. This paper provides an example of enterprise information quality metrics and employs these to explore two networked-enterprise information quality-related hypotheses. The first of these posits a relationship between measures of enterprise information quality and the effectiveness of an enterprise. The second argues that the values of selected enterprise information quality measures determine the most appropriate organizational approach option. Experimental results are presented that support these two hypotheses.
Effects of conditioning factor on anthocyanin production in strawberry suspension cultures (1994)

Abstract To investigate the effects of the conditioning factor on anthocyanin production in the cultured strawberry, Fragaria ananassa cv Shikinari, cells were cultured in LS medium supplemented with a filtered conditioned broth. Anthocyanin accumulation was greatly enhanced using media conditioned for 5–8 days. This effect was promoted by increased concentrations of the conditioned broth. The amount of anthocyanin produced in a 100% conditioned broth was about eight times higher than in the control broth after 5 days. The substance that promoted anthocyanin accumulation in the conditioned medium was thermostable, because neither cell growth nor anthocyanin accumulation were affected by boiling for 10 min. Anthocyanin production was further enhanced by adding freeze‐dried conditioned broth to freshly prepared LS medium; however, this conditioned broth affected cell growth only in the early phase of culturing. The content of peonidin‐3‐glucoside, a major anthocyanin, increased as the number of days the cell growth proceeded, while that of cyanidin‐3‐glucoside decreased. The contents of these two major anthocyanins were also changed by adding a preculture broth as a conditioning factor.
Three-dimensional monochromatic light field synthesis with a deflectable mirror array device (2006)

We investigated the problem of complex scalar monochromatic light field synthesis with a deflectable mirror array device (DMAD). First, an analysis of the diffraction field produced by the device upon certain configurations is given assuming Fresnel diffraction. Specifically, we derived expressions for the diffraction field given the parameters of the illumination wave and the tilt angles of the mirrors. The results of the analysis are used in later stages of the work to compute the samples of light fields produced by mirrors at certain points in space. Second, the light field synthesis problem is formulated as a linear constrained optimization problem assuming that mirrors of the DMAD can be tilted among a finite number of different tilt angles. The formulation is initially developed in the analog domain. Transformation to digital domain is carried out assuming that desired fields are originating from spatially bounded objects. In particular, we arrived at a <b>Dp</b> = <b>b </b>type of problem with some constraints on <b>p</b>, where <b>D</b> and <b>b</b> are known, and <b>p</b> will be solved for and will determine the configuration of the device. This final form is directly amenable to digital processing. Finally, we adapt and apply matching pursuit and simulated annealing algorithms to this digital problem. Simulations are carried out to illustrate the results. Simulated annealing performs successful synthesis when supplied with good initial conditions. However, we should come up with systematic approaches for providing good initial conditions to the algorithm. We do not have an appropriate strategy currently. Our results also suggest that simulated annealing achieves better results than MP. However, if only a part of the mirrors can be used, and the rest can be turned off, the performance of MP is acceptable and it turns out to be stable for different types of fields.
Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5–6-mer) Peptides (2021)

RAS proteins are central in the proliferation of many types of cancer, but a general approach toward the identification of pan-mutant RAS inhibitors has remained unresolved. In this work, we describe the application of a binding pharmacophore identified from analysis of known RAS binding peptides to the design of novel peptides. Using a chemically divergent approach, we generated a library of small stapled peptides from which we identified compounds with weak binding activity. Exploration of structure-activity relationships (SARs) and optimization of these early compounds led to low-micromolar binders of KRAS that block nucleotide exchange.
Uptake of the World Health Organization’s trauma care guidelines: a systematic review (2016)

Although WHO's trauma care guidelines have been widely implemented, no evidence was identified of their implementation in 143 countries. More serial needs assessments for the ongoing monitoring of capacity for trauma care in health systems and more incorporation of the guidelines into both the formal education of health-care providers and health policy are needed.
Devices and methods for increasing the speed and efficiency at which a computer is capable of modeling a plurality of random walkers using a density method (2023)

A method for increasing a speed or energy efficiency at which a computer is capable of modeling a plurality of random walkers. The method includes defining a virtual space in which a plurality of virtual random walkers will move among different locations in the virtual space, wherein the virtual space comprises a plurality of vertices and wherein the different locations are ones of the plurality of vertices. A corresponding set of neurons in a spiking neural network is assigned to a corresponding vertex such that there is a correspondence between sets of neurons and the plurality of vertices, wherein a spiking neural network comprising a plurality of sets of spiking neurons is established. A virtual random walk of the plurality of virtual random walkers is executed using the spiking neural network, wherein executing includes tracking how many virtual random walkers are at each vertex at a given time increment.
Unusual Surface Aging of Poly(dimethylsiloxane) Elastomers (2010)

We have observed an unusual increase in adhesion hysteresis and frictional forces for poly(dimethylsiloxane) (PDMS) lenses sliding on smooth glassy surfaces after a period of aging in a laboratory environment. X-ray photoelectron spectroscopy, contact angle, and in situ surface-sensitive sum frequency generation spectroscopy (SFG) measurements show no differences between an aged and unaged lens, indicating that these changes in tribological properties cannot be due to surface contaminant or degradation. Instead, we observed that the SFG intensity of the PDMS Si−CH3 symmetric band is 3 orders of magnitude higher after sliding the aged lenses. Such a large increase in the SFG signal can only arise from very well-ordered PDMS molecules induced by sliding and has important consequences in understanding adhesion hysteresis and friction.
Partial dead code elimination using slicing transformations (1997)

We present an approach for optimizing programs that uncovers additional opportunities for optimization of a statement by predicating the statement. In this paper predication algorithms for achieving partial dead code elimination (PDE) are presented. The process of predication embeds a statement in a control flow structure such that the statement is executed only if the execution follows a path along which the value computed by the statement is live. The control flow restructuring performed to achieve predication is expressed through slicing transformations. This approach achieves PDE that is not realizable by existing algorithms. We prove that our algorithm never increases the operation count along any path, and that for acyclic code all partially dead statements are eliminated. The slicing transformation that achieves predication introduces into the program additional conditional branches. These branches are eliminated in a branch deletion step based upon code duplication. We also show how PDE can be used by acyclic schedulers for VLIW processors to reduce critical path lengths along frequently executed paths.
Size reduction of a semiconductor nanowire laser by using metal coating (2007)

We explore the possibility of coating semiconductor nanowires with metal (Ag) to reduce the size of nanowire lasers operating at photon energies around 0.8-2 eV. Our results show that the material gain of a typical III-V semiconductor in nanowire may be sufficient to compensate Joule losses of such metal as Ag. The most promising mode to achieve lasing is TM<sub>01</sub> near its cutoff. To calculate the guiding properties of metal coated nanowires, we developed a finite-difference discretization approach, the details of which we also present. This approach allowed us to treat accurately the large index contrast of the nanowire/metal interface and to include nonperturbatively the imaginary parts of dielectric constants of the semiconductor core and metal coating.
Effectiveness of Ammonium Solution in Relieving Type I Mosquito Bite Symptoms: A Double-blind, Placebo-controlled Study (1998)

A randomized, double-blind, placebo-controlled study was conducted to compare the efficacy of ammonium solution with placebo in relieving type I symptoms caused by Aedes aegypti mosquitoes on 25 healthy subjects. Each subject was bitten once under laboratory conditions by Aedes aegypti mosquitoes on the volar aspect of each forearm, and then received the treatment with ammonium solution and placebo, respectively. Compared with placebo, the ammonium solution significantly (p < 0.0001) decreased itching/burning/pain immediate type symptoms from 5 to 90 min. Complete and partial relief of the symptoms was noted in 64% in the ammonium solution group compared to none in the placebo group.
Muscle phosphofructokinase deficiency in man: expression of the defect in blood cells and cultured fibroblasts (1981)

Using specific immunoprecipitation of M-type phosphofructokinase and assay of immunoprecipitate enzyme activity, it was possible to detect some M-type enzyme in normal blood cells and fibroblasts, although this isoenzyme represents a very small part of total phosphofructokinase. White blood cells and cultured fibroblasts from a patient with hereditary muscle phosphofructokinase deficiency showed normal phosphofructokinase activity and electrophoretic pattern; direct immunoneutralization results were also normal. Nevertheless, it was possible to prove the defect in these cells using the immunoprecipitation method: no active immunoprecipitates could be obtained with anti M-type antibody. The patient's red blood cells had a reduced phosphofructokinase activity which was only neutralized by anti L-type antiserum. The purification of partially deficient red cell phosphofructokinase confirmed that this enzyme only consisted of L-type subunits while, under normal conditions, both L- and M-type subunits are observed. The possibility of detecting specific enzyme defects in apparently non-affected cells could be of practical importance, especially in prenatal diagnosis.
Improved Adhesion of Different Environmental Barrier Coatings on Al2O3/Al2O3‐Ceramic Matrix Composites (2020)

In high‐temperature combustion atmospheres, well‐adhering environmental barrier coatings (EBCs) are required to protect the underlying ceramic matrix composites (CMCs) from corrosion. Herein the adhesion mechanisms of three different coatings produced by atmospheric plasma spraying (APS) on an Al 2 O 3 /Al 2 O 3 ‐CMC are investigated. In particular, the influence of surface structuring by laser ablation prior to coating production is investigated. Y 2 O 3 , yttria‐stabilized zirconia (YSZ), and Gd 2 Zr 2 O 7 are chosen as potential EBCs. The coating adhesion on CMC‐substrates with and without surface structuring is analyzed by furnace cycling, pull‐adhesion tests, and burner‐rig tests with gradient. Special interest is paid to the interactions at the coating–substrate interface before and after heat treatment and their effect on the coating adhesion and lifetime. Two different adhesion mechanisms are found: adhesion promoted by chemical reaction and adhesion promoted by mechanical interlocking.
Ultrafast nonlocal collective dynamics of Kane plasmon-polaritons in a narrow-gap semiconductor (2019)

The observation of ultrarelativistic fermions in condensed-matter systems has uncovered a cornucopia of novel phenomenology as well as a potential for effective ultrafast light engineering of new states of matter. While the nonequilibrium properties of two- and three-dimensional (2D and 3D) hexagonal crystals have been studied extensively, our understanding of the photoinduced dynamics in 3D single-valley ultrarelativistic materials is, unexpectedly, lacking. Here, we use ultrafast scanning near-field optical spectroscopy to access and control nonequilibrium large-momentum plasmon-polaritons in thin films of a prototypical narrow-bandgap semiconductor Hg<sub>0.81</sub>Cd<sub>0.19</sub>Te. We demonstrate that these collective excitations exhibit distinctly nonclassical scaling with electron density characteristic of the ultrarelativistic Kane regime and experience ultrafast initial relaxation followed by a long-lived highly coherent state. Our observation and ultrafast control of Kane plasmon-polaritons in a semiconducting material using light sources in the standard telecommunications fiber-optics window open a new avenue toward high-bandwidth coherent information processing in next-generation plasmonic circuits.
Learning from BDDs in SAT-based bounded model checking (2003)

Bounded Model Checking (BMC) based on Boolean Satisfiability (SAT) procedures has recently gained popularity as an alternative to BDD-based model checking techniques for finding bugs in large designs. In this paper, we explore the use of learning from BDDs, where learned clauses generated by BDD-based analysis are added to the SAT solver, to supplement its other learning mechanisms. We propose several heuristics for guiding this process, aimed at increasing the usefulness of the learned clauses, while reducing the overheads. We demonstrate the effectiveness of our approach on several industrial designs, where BMC performance is improved and the design can be searched up to a greater depth by use of BDD-based learning.
Calibrated uncertainty for molecular property prediction using ensembles of message passing neural networks (2021)

Abstract Data-driven methods based on machine learning have the potential to accelerate computational analysis of atomic structures. In this context, reliable uncertainty estimates are important for assessing confidence in predictions and enabling decision making. However, machine learning models can produce badly calibrated uncertainty estimates and it is therefore crucial to detect and handle uncertainty carefully. In this work we extend a message passing neural network designed specifically for predicting properties of molecules and materials with a calibrated probabilistic predictive distribution. The method presented in this paper differs from previous work by considering both aleatoric and epistemic uncertainty in a unified framework, and by recalibrating the predictive distribution on unseen data. Through computer experiments, we show that our approach results in accurate models for predicting molecular formation energies with well calibrated uncertainty in and out of the training data distribution on two public molecular benchmark datasets, QM9 and PC9. The proposed method provides a general framework for training and evaluating neural network ensemble models that are able to produce accurate predictions of properties of molecules with well calibrated uncertainty estimates.
Electrochemical carbon dioxide capture to close the carbon cycle (2020)

An overview of the state-of-the-art for capturing CO<sub>2</sub><italic>via</italic> electrochemical routes.
Reinvestigation of the stepwise character of the ferroelastic phase transition in lead phosphate-arsenate, Pb3(PO4) 2 -Pb3(AsO4)2 (1982)

The existence of static and dynamic deformation in the intermediate phase between the high and low temperature phases (para- and ferroelastic) has been examined by high resolution neutron scattering, X-ray diffusion and Raman spectroscopy. The behaviour of the order parameter was investigated through the measurement of optical birefringence under shear stress. It was found that the structural deformation of the intermediate phase, as compared with the high temperature structure, is similar to that of the ferroelastic phase but with three nearly equivalent binary axes of the monoclinic unit cell. The spontaneous thermal switching between these three axes as a dynamical effect (flip-mode) is observed in Pb3(PO4)2. In Pb3(P1-xAs xO4)2 static deformations occur at temperatures just above the ferroelastic transition point and are superposed by flipping motion at higher temperatures.
Design guidelines for composite patches bonded to cracked aluminum substrates (2002)

Design guidelines are proposed for boron fiber-reinforced epoxy composite patches bonded to cracked aluminum substrates. Stress analysis was performed on the composite patch bonded to an uncracked aluminum substrate. The load transfer via the adhesive and the stress levels in the aluminum substrate and the patch were determined. The local stress and stress distribution in the repaired V-shape side cracked substrates were obtained. The effects of crack length and patch geometries including the length and number of plies on the failure behavior of the repair were identified. The results were validated by static tensile tests. It was found that the theoretical calculations were in agreement with the experimental results. This indicates that the proposed analysis can be used as design guidelines for composite repairs of cracked structures. These guidelines coupled with a simple surface preparation technique developed in this work might aid composite patch installation in service.
Optimum antenna configurations for millimetre-wave communications from high-altitude platforms (2007)

Clustering sizes, power control strategies and antenna beamwidths, and orientations are investigated for quasi-stationary high-altitude platforms (HAPs) or other aerial platforms operating in the millimetre-wave band. It is shown that considering the carrier-to-noise and interference ratios (CNIRs) when optimising antenna beamwidths and directions can lead to significant increases in minimum CNIR levels (e.g. from 8.7 to 16.9 dB) over the coverage area. It is also shown that the optimum antenna configurations and transmit powers are a function of the weather, and should (if possible) be adjusted during periods of cloud cover and rainfall. In more practical situations in which only the transmit powers from the HAP antennas can be adjusted dynamically, it is shown that the loss in performance is &lt;2 dB relative to the optimum scheme with dynamically adjustable antenna beamwidths and orientations over a wide range of rainfall conditions.
Trends in resonance ionization spectroscopy (1986)

The author reviews the history of resonance ionization spectroscopy and then comments on the delineations of RIS with reference to many related laser processes. The substance of the paper deals with the trends in RIS and especially how the needs for sensitive analytical methods have overshadowed the orginal plan to study excited species. 9 refs., 1 fig.