gebhart/patrepeval huggingface dataset:
DENSE BUILDING INSTRUMENTATION APPLICATION FOR CITY-WIDE STRUCTURAL HEALTH MONITORING (2025)

The Community Seismic Network (CSN) has partnered with the NASA Jet Propulsion Laboratory (JPL) to initiate a campus-wide structural monitoring program of all buildings on the premises. The JPL campus serves as a proxy for a densely instrumented urban city with localized vibration measurements collected throughout the free-field and built environment. Instrumenting the entire campus provides dense measurements in a horizontal geospatial sense for soil response; in addition five buildings have been instrumented on every floor of the structure. Each building has a unique structural system as well as varied amounts of structural information via structural drawings, making several levels of assessment and evaluation possible. Computational studies with focus on damage detection applied to the campus structural network are demonstrated for a collection of buildings. For campus-wide real-time and post-event evaluation, ground and building response products using CSN data are illustrating the usefulness of higher spatial resolution compared to what was previously typical with sparser instrumentation.
Defining the Mechanistic Correlates of Protection Conferred by Whole-Cell Vaccination against Pseudomonas aeruginosa Acute Murine Pneumonia (2020)

<i>Pseudomonas aeruginosa</i> is a Gram-negative pathogen that causes severe pulmonary infections associated with high morbidity and mortality in immunocompromised patients. The development of a vaccine against <i>P. aeruginosa</i> could help prevent infections caused by this highly antibiotic-resistant microorganism. We propose that identifying the vaccine-induced correlates of protection against <i>P. aeruginosa</i> will facilitate the development of a vaccine against this pathogen. In this study, we investigated the mechanistic correlates of protection of a curdlan-adjuvanted <i>P. aeruginosa</i> whole-cell vaccine (WCV) delivered intranasally. The WCV significantly decreased bacterial loads in the respiratory tract after intranasal <i>P. aeruginosa</i> challenge and raised antigen-specific antibody titers. To study the role of B and T cells during vaccination, anti-CD4, -CD8, and -CD20 depletions were performed prior to WCV vaccination and boosting. The depletion of CD4<sup>+</sup>, CD8<sup>+</sup>, or CD20<sup>+</sup> cells had no impact on the bacterial burden in mock-vaccinated animals. However, depletion of CD20<sup>+</sup> B cells, but not CD8<sup>+</sup> or CD4<sup>+</sup> T cells, led to the loss of vaccine-mediated bacterial clearance. Also, passive immunization with serum from WCV group mice alone protected naive mice against <i>P. aeruginosa</i>, supporting the role of antibodies in clearing <i>P. aeruginosa</i> We observed that in the absence of T cell-dependent antibody production, mice vaccinated with the WCV were still able to reduce bacterial loads. Our results collectively highlight the importance of the humoral immune response for protection against <i>P. aeruginosa</i> and suggest that the production of T cell-independent antibodies may be sufficient for bacterial clearance induced by whole-cell <i>P. aeruginosa</i> vaccination.
Comparison of Plasma Bilirubin Turnover in Man with Carbon Monoxide Production Estimated Simultaneously by Blood and Gas Measurements. (1977)

Carbon monoxide production in man was measured by both gas phase and by blood analysis. Both measurements correlated well with the simultaneous measurement of plasma bilirubin turnover, but the blood phase measurement is preferred since it is subject to less error. Correspondence of endogenous CO production and plasma bilirubin turnover indicate that heme distributions is the major source of endogenous carbon monoxide in man. (Author)
GAP-JUNCTION COMMUNICATION IN CHEMICAL CARCINOGENESIS (2001)

In a recent review article, “Risk Assessment for Possible Carcinogens: A Critical Look” [1], Dr. Emmanuel Farber states, “There is a developing speculation that agents or circumstances are [tumor] ...
Radiation Myelopathy Visualized as Increased FDG Uptake on Positron Emission Tomography (2005)

A woman with a history of desmoid tumor involving the T9-T10 vertebrae was treated with local irradiation. After treatment, she developed tingling sensations in both legs. An FDG PET study demonstrated focally increased activity posterior to the vertebral bodies at the levels of T9-T10, which was vertical in orientation, corresponding to the location of the spinal cord at this level. This finding is consistent with the clinical suspicion of radiation myelopathy.
Signal detection in fractional Gaussian noise (1988)

Several results related to the reproducing kernel Hilbert space of fractional Brownian motion are presented to facilitate the study of signal detection in additive fractional Gaussian noise. This Hilbert space is completely characterized, and an alternative characterization for the restriction of this class of functions to a compact interval (0.T) is given. Infinite- and finite-interval whitening filters for fractional Brownian motion are also developed. The application of these results to the signal detection problem yields necessary and sufficient conditions for a deterministic or stochastic signal to produce a nonsingular shift when embedded in additive fractional Gaussian noise. A formula for the likelihood ratio corresponding to any deterministic nonsingular shift is developed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Impact of Guard Time Length on IEEE 802.15.4e TSCH Energy Consumption (2016)

The IEEE 802.15.4-2015 standard defines a number of Medium Access Control (MAC) layer protocols for low-power wireless communications in the IoT. Originally defined in the IEEE 802.15.4e amendment, TSCH (Time Slotted Channel Hopping) is among the proposed mechanisms. TSCH is a scheme aiming to guarantee network reliability by keeping nodes time-synchronised at the MAC layer. In order to ensure successful communication between a sender and a receiver, the latter starts listening shortly before the expected time of a MAC layer frame's arrival. The offset between the time a node starts listening and the estimated time of frame arrival is called guard time and it aims to reduce the probability of missed frames due to clock drift. In this poster, we investigate the effect of the guard time duration on energy consumption. We identify that, when using the 6tisch minimal schedule, the most significant cause of energy consumption is idle listening during guard time. Therefore, the energy-efficiency of TSCH can be significantly improved by guard time optimisation. Our performance evaluation results, conducted using the Contiki operating system, show that an efficient configuration of guard time may reduce energy consumption by up to 30%, without compromising network reliability.
Economical sampling algorithm using Fourier analysis for mapping wafer critical dimension variations (1998)

Characterizations of critical dimension (CD) errors on wafers are usually based on the assumption that the errors are random and normally distributed, and that they therefore can be fully described by a mean and 3σ value. However many sources of CD errors are known to be primarily systematic and are often spatially correlated. In order to establish an efficient measurement sampling scheme and data analysis algorithm that accounts for such nonrandom errors, we collected 900 CD data points using electrical test structures on each of nine wafers that were fabricated in two different fabrication facilities. Wafers using both phase-shifting mask and conventional mask lithography were measured. Fourier analysis was then used to study the errors in the spatial frequency domain. It was found that in all cases systematic and spatially correlated errors, in particular a set of errors that were largely repetitive with stepper field periodicity, dominated over random CD errors. By taking advantage of the correlated nature of these errors, an economical two-step sampling algorithm is defined that significantly reduces the amount of sampling needed (by approximately fourfold). By combining the results of the two-step sampling in the spatial frequency domain, an accurate map of actual error spatial distribution can be extracted. The accuracy of the scheme is verified by using subsets of the 900 data point measurements, and comparing the results to those from the full set of data.
Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity (2020)

RasGRP1 is a Ras guanine nucleotide exchange factor, and an essential regulator of lymphocyte receptor signaling. In mice, Rasgrp1 deletion results in defective T lymphocyte development. RASGRP1-deficient patients suffer from immune deficiency, and the RASGRP1 gene has been linked to autoimmunity. However, how RasGRP1 levels are regulated, and if RasGRP1 dosage alterations contribute to autoimmunity remains unknown. We demonstrate that diminished Rasgrp1 expression caused defective T lymphocyte selection in C57BL/6 mice, and that the severity of inflammatory disease inversely correlates with Rasgrp1 expression levels. In patients with autoimmunity, active inflammation correlated with decreased RASGRP1 levels in CD4<sup>+</sup> T cells. By analyzing H3K27 acetylation profiles in human T cells, we identified a RASGRP1 enhancer that harbors autoimmunity-associated SNPs. CRISPR-Cas9 disruption of this enhancer caused lower RasGRP1 expression, and decreased binding of RUNX1 and CBFB transcription factors. Analyzing patients with autoimmunity, we detected reduced RUNX1 expression in CD4<sup>+</sup> T cells. Lastly, we mechanistically link RUNX1 to transcriptional regulation of RASGRP1 to reveal a key circuit regulating RasGRP1 expression, which is vital to prevent inflammatory disease.
Imaging Assessment of Brain Injury (2017)

Abstract Imaging plays a pivotal role in discerning the extent and nature of brain injuries. Advances in neuroimaging techniques have improved sensitivity for detecting smaller lesions, improved the anatomical specificity of lesions in white matter, and improved the prognostic value of detected lesions. Novel quantitative methods allow measurements of hemorrhage and infarct volume in the acute phase of injury, and regional brain atrophy and functional disconnectedness months after injury. It is likely that the success of future clinical trials of neuroprotective therapies will be dependent on reliable and validated neuroimaging biomarkers of injury and recovery. This chapter describes neuroimaging modalities that are currently being utilized in clinical and experimental settings and their implications for the development and testing of neuroprotection strategies.
Sind Festkörperreaktionen ohne Beteiligung von Wasser möglich? (1985)

Abstract An Beispielen wird gezeigt, daß die reaktionsbeeinflussende Wirkung des Wassers bei Festkörperreaktionen häufig eintritt und eine absolute Wasserfreiheit in zahlreichen Fällen bisher nicht erreicht werden konnte. Die Rolle des Wassers liegt in der Regel bei Festkörperreaktionen in einer Erniedrigung der Aktivierungsenergie. Festkörperreaktionen bedürfen aber prinzipiell nicht der Anwesenheit des Wassers.
Comments on ‘‘Kramers–Kronig relationships and wave propagation in composites’’ by A. I. Beltzer [J. Acoust Soc. Am. 7 3, 355 (1983)] (1983)

It will be shown that local approximations to the Kramers–Kronig relations are not applicable to scattering systems.
Lactose-based surfactants complexable with oligonucleic acids as gene delivery agents (2022)

Abstract Advances in molecular medicine related to the treatment of genetic disorders and cancer require finding new pathways for gene transfer. Nonviral delivery methods rely on the application of polymers, liposomes and cationic lipid systems used as vehicle. Among these systems, there is increasing interest in surfactants, which, due to their ability to complex with nucleic acids can deliver into cell DNA or RNA molecules of almost any size, which is unattainable with viral gene delivery systems.The main aim of this study was to determine the effect of the concentration of lactose-based surfactants (zwitterionic derivatives of sulfobetaine with carbohydrate moieties) on the structure of DNA/RNA as well as to explore their abilities of nucleic acid complexation. Structural studies of DNA or RNA in complexes with surfactants of two types at various concentrations were conducted using circular dichroism (CD) spectroscopy, gel electrophoresis (GE) and synchrotron radiation small angle X-ray scattering (SR-SAXS). Our studies showed that the examined surfactants have excellent properties of forming complexes with DNA and RNA. Additionally, to determine the cytotoxicity and transfection abilities of the studied lipoplexes, preliminary tests were performed in HeLa and fibroblast cells. The obtained results suggest that these systems have relatively low toxicity; however, further research is needed in this area.
ChemInform Abstract: 1,3‐DIPOLAR CYCLOADDITIONS. 87. STUDY OF N‐PHENYLNITRILIMINE (1983)

Abstract Während disubstituierte Nitrilimine in großer Zahl als nicht isolierbare 1,3‐Dipole bereits in Cycloadditionen genutzt wurden, wird hier die Titelverbindung (III) als erster monosubstituierter, abfangbarer Vertreter vorgestellt.
Automatic Self-Reconfiguration of System-on-Chip Peripherals (2007)

A technique is presented which allows an FPGA-based reconfigurable system-on-chip to automatically and dynamically load hardware peripheral controllers and software device drivers depending on the system's automated identification of peripheral boards which are connected to the FPGA. The technique loads peripheral detection modules into peripheral controller slots at system startup, and after these modules identify the peripheral, the correct hardware controllers and software drivers are loaded.
Defining cell-matrix combination products in the era of pluripotency (2013)

Human pluripotent stem (hPS) cells provide an attractive opportunity for the manufacture of a wide array of therapeutic cell types. The challenges to commercialization include the thousand-fold diversity of cell types emerging from hPS cells and the associated difficulties in validating processes to reliably generate cells with precise identity and purity. Improved methods of controlling the dosage and migration of hPS-derived cells in solid tissues are also needed. To directly address these issues, we clonally expanded proliferating lineages of cells that were intermediate in regard to their state of differentiation between hPS and terminally differentiated cells. These cells called monoclonal embryonic progenitors (hEP), are expandable mortal lineages with diverse site-specific homeobox gene expression and multipotentiality. In this review, we discuss methods of generating combination products wherein the fate space of precisely identified monoclonal hEP cells is mapped by differentiating the cells in vitro in HyStem-3D bead arrays in the presence of diverse growth factors. This combination of discovery processes has the potential to translate directly into cell-matrix formulations that can be used to generate pre-clinical data leading to human clinical trials and potentially new medical therapies.
625 The neuron activity potential by the local cooling of a cerebrum cortex : Considering of epileptiform discharges suppression mechanism (2008)

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A Solid-State Pathway towards the Tunable Carboxylation of Cellulosic Fabrics: Controlling the Surface’s Acidity (2021)

We report on a tunable solid-state approach to modify the acidity of cotton substrates using citric, oxalic, and fumaric acids. The first stage of the method involves soaking the cotton swatches in an ethanolic saturated solution of the corresponding acid. After drying, the carboxylation reaction proceeds at high temperature (T > 100 °C) and in solid state. We quantified the effect of temperature and reaction time on the solid-state carboxylation reaction, which allowed us to tune the carboxylation degree and the acidity of the surface. We characterized the modified cotton by performing adsorption isotherms and by determining the kinetics of adsorption of a cationic dye: methylene blue (MB). We found that the MB uptake kinetics varied as a function of the acidic strength of the surface, which is closely related to the strength of the acid used for surface modification. The proposed solid-state cotton carboxylation procedure allows us to achieve sustainable cotton modification, which constitutes a starting point for several applications using cotton as the substrate.
A Comprehensive Study of Composition and Evaluation of Vanilla Extracts in US Retail Stores (2010)

This chapter contains sections titled: History Uses of Vanilla in the Industry Major US Vanilla Companies Introduction to the Study Materials and Methods Results and Discussion Conclusion and Recommendation References
Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors (2015)

Clinicaltrials.gov NCT00234234 , registered 04 November 2008; NCT00767325 , registered 05 October 2005.
Adaptive Disturbance Rejection Controller for Pathological Tremor Suppression With Permanent Magnet Linear Motor (2017)

This paper presents an adaptive disturbance rejection (ADR) controller developed for the suppression of the pathological tremor in the humans’ wrist. An experimental setup, based on a slotted permanent magnet linear motor (PMLM), was developed to evaluate the ADR’s performance in real-time suppression of the tremor signal recorded from Parkinson’s disease patients. A model-base compensator was utilized to minimize the resistive and cogging forces exhibited by the PMLM. Experimental results showed an average tremor amplitude suppression of 32.61 dB (97.6%) in the first, and 15.23 dB (82.7%) in the second tremor frequency respectively. The average magnitude of the resistance force induced by the system against voluntary motion was 0.36 N. Furthermore, to evaluate the tremor suppression performance of the presented technique the results were compared with two other studies that used pneumatic actuators and magneto-rheological dampers (MRD). The performance of the PMLM was analogous to actively controlled pneumatic actuators and was significantly better than the semi-active controller with MRD.
Abstract 113: Investigating the role of high mobility group a2 (HMGA2) truncated isoform in promoting oxidative stress in PCa cells (2022)

Abstract Prostate cancer (PCa) is one of the most commonly diagnosed malignancies among men worldwide and remains the second leading cause of cancer related death in the United States. Oxidative stress has been shown to be increase in several cancers including prostate cancer. In fact, oxidative stress in prostate cancer is suggested to be a direct result of cell exposure to reactive oxygen species (ROS). High mobility group A 2 (HMGA2), a non-histone protein, is an oncogene that is up-regulated in several cancers. This protein has ability to undergo chromosomal rearrangement and alternative splicing, causing its full length/wild type HMGA2 (HMGA2-WT) to become the truncated losing its 3’UTR leading to the generation of HMGA2 truncated (HMGA2-TR). We have previously shown HMGA2-WT’s involvement in epithelial mesenchymal transition (EMT), however, the functional role of HMGA2-TR has not yet been dissected. We hypothesize that truncated HMGA2’s involvement with oxidative stress leads to prostate cancer progression. We analyzed the baseline expression of wild-type vs.truncated HMGA2 in prostate patient tissue and cells lines by real-time PCR and western blot analyses. Prostate cancer patient tissue and some cell lines expressed increasing amounts of both wild-type and truncated HMGA2with increasing tumor grade, when compared to normal epithelial cells. RNA-Seq analysis of LNCaP prostate cancer cells stably overexpressing HMGA2-WT, HMGA2-TR, or empty vector (Neo) control revealed thatHMGA2-TR cells display increased oxidative stress compared to HMGA2-WT or Neo control cells. This was also confirmed by analysis of basal reactive oxygen species (ROS) levels, and the ratio of GSH/GSSG andNADP/NADPH utilizing metabolomics. Additionally, proteomic analysis showed that HMGA2-TR protein interacted with several proteins, including a cytoplasmic stress granule protein G3BP1 that responds to oxidative stress. Transient knockdown of G3BP1 increased ROS in HMGA2-TR cells. These studies may therefore uncover novel role for truncated HMGA2 in oxidative stress. Acknowledgements: These studies were supported by the NIH/NIMHD/RCI Grant #5G12MD007590-31,NIH/NIGMS/RISE Grant #5R25GM060414 Citation Format: Taaliah Campbell, Ohuod Hawsawi, Nathan Bowen, Valerie Odero-Marah. Investigating the role of high mobility group a2 (HMGA2) truncated isoform in promoting oxidative stress in PCa cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 113.
Inhibition of the acute-phase response in vivo by anti-gp130 monoclonal antibodies. (1996)

The acute-phase response is believed to be an important systemic defence reaction to inflammation during infection, trauma, injury or neoplasia. Although the interleukin-6 (IL-6) family of cytokines appear to be the major regulators of the acute-phase reaction, the exact biological significance of this process remains unknown. In this study, a panel of monoclonal antibodies (Mabs) was raised against the extracellular domain of human gp130 (the common signal transducing chain of the IL-6 cytokine family) in order to inhibit the biological activity of IL-6-like cytokines in vivo. Mabs designated 4B11 and 2H4 were most effective in the inhibition of the in vitro acute-phase response on hepatoma cells and prevented the IL-6-induced growth inhibition of A375 cells. Administration of the antibodies to dogs at a dosage of 8 mg/kg/d showed that 2H4 was a potent inhibitor of the IL-6-induced (40 micrograms/kg/d) acute-phase response, abrogating IL-6-mediated increments in fibrinogen, C-reactive protein and the platelet count. This antibody, the first described to abrogate the acute-phase response in vivo, may not only permit development of a new anti-inflammatory strategy, but provides an excellent tool for defining the function of acute-phase proteins in inflammation and infection.
Circadian Surprise—It's Not All About Transcription (2012)

Posttranscriptional regulation plays a substantial role in controlling the mammalian circadian clockwork.
A remark on a power gain inequality for interconnected systems (2002)

Power gain is a simple generalization of L/sub 2/-gain that admits the analysis of a class of nonlinear systems with dynamics that exhibit an attracting set. In the paper, a notion of power gain is defined for interconnected systems. This power gain inequality allows the behaviour of the interconnected system to be described in terms of the component subsystems. A small gain theorem follows and an example is presented.
Cyclooxygenase-2 and angiogenesis in prostate cancer (2005)

Chronic inflammation has been associated with resulting in malignancies in prostate cancer patients. In the May 2005 issue of Clinical Cancer Research, a study by Wang et al. demonstrates a relationship between COX-2 expression and the local chronic inflammation within prostate cancer and the increased angiogenesis. Confirming the existence and extent of this relationship is essential in the determination of therapeutic modalities for the prevention and treatment of prostate cancer.