gebhart/patrepeval huggingface dataset:
Cytotoxic Constituents of Pachyrhizus Tuberosus from Peruvian Amazon (2013)

Investigations into the chemical constituents of the seeds of the neglected tuber crop Pachyrhizus tuberosus (Leguminosae) resulted in the isolation of seven components: five rotenoids [12a-hydroxyerosone (1), 12a-hydroxydolineone (2), erosone (3), 12a-hydroxyrotenone (4) and rotenone (6)], a phenylfuranocoumarin [pachyrrhizine (5)] and an isoflavanone [neotenone (7)]. The compounds were isolated using several chromatography techniques and characterized and verified by NMR and HPLC/MS. The MTT assay was used to examine the selective cytotoxic effects of the methanolic P. tuberosus extract and isolated compounds in two human cancer cell lines [breast (MCF-7) and colorectal (HCT-116)] and in non-transformed human fibroblasts (MRC-5); IC50 values were calculated. The methanolic P. tuberosus extract displayed respectable cytotoxic effects against HCT-116 and MCF-7 cells with IC50 values of 7.3 and 6.3 microg/mL, respectively. Of the compounds, 6 exacted greatest cytotoxicity and selectivity towards the cancer cell lines tested, yielding IC50 values of 0.3 microg/mL against both MCF-7 and HCT-116 cells, and a 6-fold reduced activity against MRC-5 fibroblasts. Compound 4 also demonstrated cytotoxicity against MCF-7 and HCT-116 (1.1 and 1.8 microg/mL, respectively), and reduced cytotoxicity towards MRC-5 cells (7.5 mirog/mL). The results revealed from the in vitro cytotoxic MTT assay are worthy of further antitumor investigation.
Fibroblast growth factor 23 (FGF 23) and phosphocalcic metabolism in chronic kidney disease. (2012)

During the evolution of CKD, changes of FGF 23 and PTH would be the earliest markers. Calcium and 25 vit D3 do not vary with changes in the progression of CKD. Values of FGF 23 show an important correlation with PTH, 1,25 vit D3, P and estimated glomerular filtration rate.
La granja escuela infantil: uan propuesta para la educación infantil desde la educación ambiental (2006)

El articulo forma parte de un monografico de la revista dedicado al aprendizaje escolar mas alla de la escuela.- El resumen esta tomado de la revista
A Decentralized Public Key Infrastructure with Identity Retention. (2014)

Public key infrastructures (PKIs) enable users to look up and verify one another’s public keys based on identities. Current approaches to PKIs are vulnerable because they do not offer sufficiently strong guarantees of identity retention; that is, they do not effectively prevent one user from registering a public key under another’s already-registered identity. In this paper, we leverage the consistency guarantees provided by cryptocurrencies such as Bitcoin and Namecoin to build a PKI that ensures identity retention. Our system, called Certcoin, has no central authority and thus requires the use of secure distributed dictionary data structures to provide efficient support for key lookup. 1
Excilamps and their Applications (2015)

Abstract An innovative class of sources of spontaneous ultraviolet and vacuum ultraviolet radiation, the so‐called excilamps, based on the nonequilibrum radiation of exciplex or excimer molecules, is described. The design and some technical characteristics of traditional excilamps excited by a dielectric barrier discharge are presented. The data concerning newly developed types of excilamps excited by runaway‐electrons‐preionized diffuse discharge both in single and pulse‐periodic modes are given as well. Some novel applications of excilamps in photochemistry, the effect of ultraviolet and vacuum ultraviolet radiation on the physiological action of living organisms, photosynthesis, and growth of plants, and the use of excilamps for pre‐sowing treatment of seeds are explained in detail.
Towards an Integrated Observing System: In Situ Observations (2010)

The research and operational community represented at the OceanObs'09 conference has stated clearly that the future global ocean observing system must focus on applications that society cares about. This necessitates expanding the current system to include biogeochemical and ecosystem observations. There was also an unambiguous message that various gaps in the system need to be closedin terms of technology, sampling, and geographical coverage. Closer integration is needed to exploit synergies between platforms and communities, and to provide seamless data access across all components. Capacity building and training the next generation of ocean observers is another area requiring work and funding. This paper argues that an efficient way forward is to (1) maintain the existing system, (2) close gaps, especially geographic ones, and (3) enhance Argo, OceanSITES (OCEAN Sustained Interdisciplinary Time series Environment Observation System) and VOS (Volunteer Observing Ship) to serve and be jointly operated with the biogeochemistry and ecosystem communities.
Monitoring link delays with one measurement host (2005)

We present RCM, a system to monitor link delays on a network using a single measurement host. RCM is a combination of a new measurement system and a new network tomography technique. The measurement system employs tunnels to connect to border routers where it can source and sink measurements across the network. RCM uses network tomography to calculate the delays across individual network links from these measurements. The network tomography technique expands on previous linear algebra techniques to deal with the limitations of the resulting data without assuming either link delay symmetry or a particular topology. The network tomographic technique is compared against direct measurements in simulation to ensure accuracy. RCM is deployed on a large ISP's network to diagnose the cause of end-to-end delays, from which additional results are presented. The results are compared against known behaviors of the network to ensure the results are consistent with those behaviors. The system is analyzed for its ability to pin-point the cause of changes in end-to-end delay.
HARADA'S DISEASE AND VOGT-KOYANAGI SYNDROME (1951)

THE PURPOSE of this paper is to present a case of Harada's disease, to emphasize certain unusual clinical findings and to point out that the differences between the Vogt-Koyanagi syndrome and Harada's disease are superficial and do not warrant classification of the two as separate disorders. Harada's disease, like the Vogt-Koyanagi syndrome, is a severe nontraumatic bilateral uveitis, usually with one or more associated features; namely, alopecia, poliosis, vitiligo and dysacousia. In a large percentage of the cases reported belonging to both groups, there is a prodromal meningismal episode which may be marked by nausea, emesis, fever, severe headache, drowsiness, vertigo, pleocytosis and occasionally other neurological findings. While the incidence of both diseases is higher among the heavily pigmented races and between the ages of 20 and 50, it does not seem related to sex, geographic location or economic factors. The course of each illness is chronic, running for many
Diffusion coefficient of hydrogen in a Pd‐Ag membrane: Effect of hydrogen solubility (1995)

Abstract The permeabilities of hydrogen through a Pd 75 ‐Ag 25 membrane have been measured at temperatures ranging from 423 to 573 K and under hydrogen pressure differences ranging from 69 to 256 kPa. From the available literature solubility data a neural network model has been developed in order to simulate the variation of the hydrogen content in the alloy as a function of pressure and temperature. Then, from steady state permeability measurements and calculated solubilities, the diffusion coefficients of hydrogen have been computed. At a given temperature, the diffusion coefficient has been found to decrease with the hydrogen content (0.1 ≤ n = H/M ≤ 0.37). A simple relation is then suggested to predict the variation of the diffusion coefficient on both temperature and hydrogen content. To account for the variation of the diffusion coefficient with n, the integration of Fick's law of diffusion has been performed numerically, resulting in non‐linear profile of hydrogen content through the membrane under steady state permeation.
Detection of sleep apnea in single channel ECGs from the PhysioNet data base (2002)

The authors have analyzed single channel ECGs from the Marburg Sleep Laboratory downloaded from Physionet. 35 Data sets with sleep apnea annotation (Learning Set) and 35 testing cases without annotation were available. The authors' analysis and annotations are based on spectral components of heart rate variability. Frequency analysis was performed using Fourier and Wavelet Transformation with appropriate application of the Hilbert Transform. Classification is based on four frequency bands. The authors defined: ULF band (0-0.013 Hz) VLF band (0.013-0.0375 Hz) LF band (0.0375-0.06 Hz) and the HF band (0.17-0.28 Hz). For classification linear discriminant functions using spectral components and other variables derived from the recorder have been used. Classification of cases by means of three variables resulted for the Learning Set in a sensitivity for apnea of 95.0% at a specificity of 100.0% and for the minutes annotation a sensitivity was 90.8% and specificity 92.7% Allocation per minute based on a discriminant function using 30 variables.
Compressed Sensing Performance Bounds Under Poisson Noise (2010)

This paper describes performance bounds for compressed sensing (CS) where the underlying sparse or compressible (sparsely approximable) signal is a vector of nonnegative intensities whose measurements are corrupted by Poisson noise. In this setting, standard CS techniques cannot be applied directly for several reasons. First, the usual signal-independent and/or bounded noise models do not apply to Poisson noise, which is nonadditive and signal-dependent. Second, the CS matrices typically considered are not feasible in real optical systems because they do not adhere to important constraints, such as nonnegativity and photon flux preservation. Third, the typical <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">l</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> - <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">l</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> minimization leads to overfitting in the high-intensity regions and oversmoothing in the low-intensity areas. In this paper, we describe how a feasible positivity- and flux-preserving sensing matrix can be constructed, and then analyze the performance of a CS reconstruction approach for Poisson data that minimizes an objective function consisting of a negative Poisson log likelihood term and a penalty term which measures signal sparsity. We show that, as the overall intensity of the underlying signal increases, an upper bound on the reconstruction error decays at an appropriate rate (depending on the compressibility of the signal), but that for a fixed signal intensity, the error bound actually grows with the number of measurements or sensors. This surprising fact is both proved theoretically and justified based on physical intuition.
Venoarterial Extracorporeal Membrane Oxygenation With or Without Advanced Intervention for Massive Pulmonary Embolism (2023)

Our study found no difference in survival in patients with MPE who received advanced interventions prior to ECMO, and a slight non-significant benefit in those who received advanced interventions while on ECMO.
Real-time target and pose recognition for 3-D graphical overlay (1997)

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.
Acid dissociation constants for plastocyanin in the Cu I state (1985)

Acid dissociation constants for four plastocyanins in the PCuI state determined by n.m.r. are compared with those determined by a kinetic method using [Fe(CN)6]3– and [Co(phen)3]3+(phen = 1,10-phenanthroline) as oxidants.
Recording of uterine activity from the abdominal lead EMG (1980)

With external tocography some form of pressure or force transducer is fastened to the abdominal wall by means of an elastic belt. Uterine contractions produce changes in the displacement of a sensor pin which acts on the transducer, producing an electrical signal that corresponds to the relative uterine pressure. External tocography, however, has the drawback that it is subject to many factors which may influence the results of the measurement. We feel that the limitations of tocography cannot be eliminated by technical improvements of the measuring equipment, and therefore the possibility of recording the uterine contractions from the abdominal lead electromyogram (EMG) without losing any information regarding tocography has been studied. As a result of the study it has become evident that the recording of uterine activity using the EMG is more reliable than tocography and offers even additional information about the excitation and propagation of the contractions. The basic methods that have been developed and the results of clinical tests are presented here.
Follow Me, If You Can: A Framework for Seamless Migration in Mobile Edge Cloud (2020)

Mobile Edge Cloud (MEC) enables cloud services in the proximity of user equipments. MEC will be greatly beneficial to various latency-sensitive applications such as autonomous cars and augmented reality/virtual reality applications. The challenge is to maintain an uninterrupted service in the presence of user's mobility. In maintaining a consistent state of MEC application, we advocate the decoupling of the state storage component from the computing one. We leverage a key-value storage layer to synchronize states between MEC servers. Subsequently, we propose a distributed key-value store framework, which decouples MEC application design into processing and state, to ensure service continuity. Evaluation results show that our solution reduces downtime by half in most of the cases, even under high load of state update. Furthermore, under moderate load of state updates, the framework can eliminate downtime completely.
Computer matching of pyrolysis chromatograms of pathogenic microorganisms (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComputer matching of pyrolysis chromatograms of pathogenic microorganismsF. M. Menger, G. A. Epstein, D. A. Goldberg, and E. ReinerCite this: Anal. Chem. 1972, 44, 2, 423–424Publication Date (Print):February 1, 1972Publication History Published online1 May 2002Published inissue 1 February 1972https://doi.org/10.1021/ac60310a046Request reuse permissionsArticle Views19Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (214 KB) Get e-Alertsclose Get e-Alerts
Faculty Opinions recommendation of Oral, direct Factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip replacement. (2006)

BACKGROUND: Joint replacement surgery is an appropriate model for dose-ranging studies investigating new anticoagulants.OBJECTIVES: To assess the efficacy and safety of a novel, oral, direct factor Xa (FXa) inhibitor--BAY 59-7939--relative to enoxaparin in patients undergoing elective total hip replacement.METHODS: In this double-blind, double-dummy, dose-ranging study, patients were randomized to oral BAY 59-7939 (2.5, 5, 10, 20, or 30 mg b.i.d.), starting 6-8 h after surgery, or s.c. enoxaparin 40 mg once daily, starting on the evening before surgery. Treatment was continued until mandatory bilateral venography was performed 5-9 days after surgery.RESULTS: Of 706 patients treated, 548 were eligible for the primary efficacy analysis. The primary efficacy endpoint was the incidence of any deep vein thrombosis, non-fatal pulmonary embolism, and all-cause mortality; rates were 15%, 14%, 12%, 18%, and 7% for BAY 59-7939 2.5, 5, 10, 20, and 30 mg b.i.d., respectively, compared with 17% for enoxaparin. The primary efficacy analysis did not demonstrate any significant trend in dose-response relationship for BAY 59-7939. The primary safety endpoint was major, postoperative bleeding; there was a significant increase in the frequency of events with increasing doses of BAY 59-7939 (P = 0.045), but no significant differences between individual BAY 59-7939 doses and enoxaparin.CONCLUSIONS: When efficacy and safety were considered together, the oral, direct FXa inhibitor BAY 59-7939, at 2.5-10 mg b.i.d., compared favorably with enoxaparin for the prevention of venous thromboembolism in patients undergoing elective total hip replacement. PMID: 16409461
Integrating Grant‐funded Research into the Undergraduate Biology Curriculum Using IMG‐ACT (2013)

It has become clear in current scientific pedagogy that the emersion of students in the scientific process in terms of designing, implementing, and analyzing experiments is imperative for their education; as such, it has been our goal to model this active learning process in the classroom and laboratory in the context of a genuine scientific question. Toward this objective, the National Science Foundation funded a collaborative research grant between a primarily undergraduate institution and a research-intensive institution to study the chemotactic responses of the bacterium Pseudomonas putida F1. As part of the project, a new Bioinformatics course was developed in which undergraduates annotate relevant regions of the P. putida F1 genome using Integrated Microbial Genomes Annotation Collaboration Toolkit, a bioinformatics interface specifically developed for undergraduate programs by the Department of Energy Joint Genome Institute. Based on annotations of putative chemotaxis genes in P. putida F1 and comparative genomics studies, undergraduate students from both institutions developed functional genomics research projects that evolved from the annotations. The purpose of this study is to describe the nature of the NSF grant, the development of the Bioinformatics lecture and wet laboratory course, and how undergraduate student involvement in the project that was initiated in the classroom has served as a springboard for independent undergraduate research projects.
High-gain step-profiled integrated diagonal horn-antennas (1992)

Dipole-excited integrated horn antennas are limited by their large flare angle of 70 degrees , which is inherent in the anisotropic etching process of
Simulation-Based Verification of Cardiac Pacemakers With Guaranteed Coverage (2015)

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Editor's notes:</i> <p xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">The testing of medical devices poses numerous challenges due to continuous interactions between the physical processes and the cyber components. This paper highlights the main challenges for the design and verification of pacemakers and describes a framework based on discrepancy functions for investigating and validating the time-bounded safety properties as well as determining the safe ranges for the system parameters. <p xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <i>—Paul Bogdan, University of Southern California</i>
Single-substrate decohesion test (SSDT) for interfacial fracture toughness measurement (2004)

We have developed a test method, called the Single-Substrate Decohesion Test (SSDT), to measure the interfacial fracture toughness for thin-film interfaces used in microelectronic applications. SSDT can be used to measure the interfacial fracture toughness over a range of mode mixity. In this work the results of the measurement of the full mode mixity versus interfacial fracture toughness curve for a submicron physical vapor deposited titanium thin film on a silicon substrate using SSDT are presented.
IC‐P2‐075: Use of regional thickness measures to predict decline in questionable AD dementia: Comparison to standard volumetric measures (2008)

We previously used exploratory analyses to determine that clinically mild Alzheimer's disease (AD) is reliably associated with a “cortical signature” of thinning in a specific set of regions in medial (MTL), inferior (ITG), and polar temporal (TP), inferior, superior (SPL), and medial parietal, and inferior and superior frontal cortices. We sought to determine whether the pattern of AD-related thinning is present in individuals with questionable dementia of the Alzheimer type (QAD) prior to mild AD and whether a greater degree of regional thinning predicts mild AD dementia. Participants included 49 older adults with QAD (Clinical Dementia Rating (CDR)=0.5) at the time of structural MRI scanning. Nine regions of interest (ROIs) identified from an exploratory analysis comparing a separate sample of Older Controls to mild AD (CDR=1) patients were used to measure AD signature cortical thickness in these participants. We also measured “mean AD signature” thickness across all 9 regions. In addition, mean thickness across the entire cortex, and whole brain, hippocampal and entorhinal volumes were calculated. Longitudinal clinical follow-up after scanning was used to classify participants as progressors to CDR=1 or non-progressors. Longitudinal follow-up revealed that 20 participants converted to mild AD dementia after approximately 2.5 years. At baseline, these QADs showed milder thinning in the cortical ROIs as well as milder hippocampal and entorhinal atrophy than is typically seen in mild AD. Compared to the non-progressors, the progressors showed thinning in MTL, ITG, TP and SPL. Effect sizes for group differences were higher for many regional thickness as compared to volume measures. Using receiver operating characteristic curves, mean AD signature cortical thickness was the best at predicting progression to mild AD with 83% sensitivity and 65% specificity as compared to entorhinal volume, which achieved 72% sensitivity and 65% specificity. Thinning in specific cortical areas known to be affected by AD is detectable in individuals with QAD and predicts conversion to mild AD dementia. This method could be useful for identifying individuals at relatively high risk for progression from QAD to mild AD dementia within a few years, which may be of use in clinical trials.