gebhart/patrepeval huggingface dataset:
Using Iterative Computation of Connected Graph Components for Post-Entity Resolution Transitive Closure (2018)

Although the Kolb (Kolb et al, 2014) algorithm for the iterative computation of connected graph components was specifically designed for execution in the HDFS environment using Map/Reduce, the algorithm can also be employed in a non-distributed computing environment to support post-entity resolution (ER) transitive closure (blocking). Post-ER transitive closure is an important technique for controlling block size in ER processes, especially when using multiple match keys (Talburt, Zhou, 2015). This paper describes an implementation of the Kolb algorithm in Java, and an example of its application to post-ER transitive closure (blocking) using the OYSTER open source ER system.
Combination of single walled carbon nanotubes/graphene oxide with paclitaxel: a reactive oxygen species mediated synergism for treatment of lung cancer (2013)

Heterogeneity in tumors has led to the development of combination therapies that enable enhanced cell death. Previously explored combination therapies mostly involved the use of bioactive molecules. In this work, we explored a non-conventional strategy of using carbon nanostructures (CNs) [single walled carbon nanotube (SWNT) and graphene oxide (GO)] for potentiating the efficacy of a bioactive molecule [paclitaxel (Tx)] for the treatment of lung cancer. The results demonstrated enhanced cell death following combination treatment of SWNT/GO and Tx indicating a synergistic effect. In addition, synergism was abrogated in the presence of an anti-oxidant, N-acetyl cysteine (NAC), and was therefore shown to be reactive oxygen species (ROS) dependent. It was further demonstrated using bromodeoxyuridine (BrdU) incorporation assay that treatment with CNs was associated with enhanced mitogen associated protein kinase (MAPK) activation that was ROS mediated. Hence, these results for the first time demonstrated the potential of SWNT/GO as co-therapeutic agents with Tx for the treatment of lung cancer.
Gene Therapy for Cardiomyopathies (2019)

Heart disease remains the prevalent cause of premature death and accounts for a significant proportion of all hospital admissions. Molecular genetics was integrated quite late in cardiology, but introduced new concepts like sarcolemmopathies, cytoskeletalopathies, and channelopathies useful to better understand the pathophysiology of the development of inherited cardiomyopathies (CMs). As our understanding of the cellular and molecular processes involved in the development and progression of heart disease improved, new therapeutic targets were identified, as were novel approaches such as delivery of genes to replace defective or deficient components and thereby restore structure or function in a diseased heart. We discuss gene addition strategies in the context of monogenic disorders. Moreover, a broader nucleic acid-based modulation of cardiac gene expression for the treatment of cardiac diseases might have larger clinical indications. Inadequate gene delivery remains a potential cause of negative trials. However, progress in innovative formulations and clinically relevant ways of administration should lead to significant progress in the future. Cardiac gene therapy will be integrated into the therapeutic armamentarium for CM and heart failure.
Transcription of the groESL operon in Pseudomonas aeruginosa PAO1 (1998)

Northern hybridization and S1 nuclease mapping demonstrated that the groES and groEL genes in Pseudomonas aeruginosa were transcribed as a bicistronic mRNA of 2.2 kb. Two transcription start sites and a transcription termination site were mapped. Overlapping consensus sequences for σ32- and σ70-dependent promoters were found in the upstream region of groES. Levels of groESL-specific mRNA were increased about 2-fold upon heat shock. This response differs from the dramatic enhancement (more than 10-fold) of groESL transcription after heat shock observed in other bacterial species.
The Senior Citizens Going on Vigorously are Increasing (2012)

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19‐5: Invited Paper : Low‐Cost Micro‐LED Displays for All Applications (2017)

Micro‐LED has been considered the ultimate of what emissive displays can offer. In theory, these displays should not have any of their predecessor challenges. However, the reality is different and several major challenges should be addressed priorr to micro‐LED makes a huge entry.
Phase Transfer of Aqueous CdS Nanoparticles by Coordination with Octadecanethiol Molecules Present in Nonpolar Organic Solvents (2000)

The transfer of CdS nanoparticles of dimensions 60 Å synthesized in an aqueous environment into petroleum ether (pet ether) by coordination of the nanoparticles with octadecanethiol (ODT) molecules present in the organic phase is described. The phase transfer of the CdS nanoparticles into pet ether occurs extremely rapidly during vigorous stirring of the biphasic mixture (CdS-in-water/ODT-in-pet ether). Hydrophobization of the CdS nanoparticles due to surface coordination of ODT facilitates the phase transfer process. The hydrophobized CdS nanoparticles may be precipitated and redispersed in different nonpolar organic solvents without an apparent distortion in the particle size distribution. Close-packed CdS nanoparticle thin films were formed by immersion of suitable substrates in the organic solutions and evaporation of the organic component. The CdS nanoparticles have been characterized at different stages of the synthesis procedure using UV−vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction, thermogravimetry, X-ray photoemission spectroscopy (XPS), and contact angle measurements.
Technology mapping and architecture evalution for k/m -macrocell-based FPGAs (2005)

In this article, we study the technology mapping problem for a novel field-programmable gate array (FPGA) architecture that is based on k -input single-output programmable logic array- (PLA-) like cells, or, k/m -macrocells. Each cell in this architecture can implement a single output function of up to k inputs and up to m product terms. We develop a very efficient technology mapping algorithm, k_m_flow, for this new type of architecture. The experimental results show that our algorithm can achieve depth-optimality on almost all the testcases in a set of 16 Microelectronics Center of North Carolina (MCNC) benchmarks. Furthermore it is shown that on this set of benchmarks, with only a relatively small number of product terms ( m ≤ k + 3), the k/m -macrocell-based FPGAs can achieve the same or similar mapping depth compared with the traditional k -input single-output lookup table- ( k -LUT-) based FPGAs. We also investigate the total area and delay of k/m -macrocell-based FPGAs and compare them with those of the commonly used 4-LUT-based FPGAs. The experimental results show that k/m -macrocell-based FPGAs can outperform 4-LUT-based FPGAs in terms of both delay and area after placement and routing by VPR on this set of benchmarks.
Chasing femtoseconds - how accelerators can benefit from economies of scale in other industries (2011)

Building accelerators we frequently push the limits of what is possible in terms of performance. When trying to solve a very challenging engineering problem, we normally resort to specialization; we narrow our focus. This talk suggests a possible alternative path. Huge benefits and great results can be achieved by combining creative ideas and approaches with ideas and solutions borrowed from the economies of scale like telecommunications. The aim of the talk is to show possibilities for combining ideas, technologies and components from different industries into innovative products. TIMING ACCURACY: JITTER & DRIFT One of the design requirements of modern particle accelerators is precise timing and synchronization of the machine components and user experiments at different physical locations. Before designing a high-accuracy timing system, some basic definitions and limitations need to be considered first to select the most suitable technology for a certain task. Timing accuracy includes at least two different specifications: • Short-term inaccuracy described as phase noise or jitter . • Long-term inaccuracy described as wander or drift.
Role of Nitric Oxide in Extracellular Matrix Metabolism and Inflammation in Diabetic Wound Healing (2011)

Diabetes and its subsequent complications present a significant challenge to our healthcare system. In particular, chronic diabetic wounds are a major cause of morbidity and use of healthcare resources in the U.S. Recent statistics reveal that 15% of diabetic patients develop foot and ankle chronic ulcers (Singh et al., 2005). Of these chronic wounds, 1 in 5 results in amputation. Further statistics reveal that 60% of nontraumatic lower-limb amputations occur in people with diabetes (Reiber, 2001). Chronic diabetic wounds result in a state of chronic inflammation about the wound site with decreased collagen and nitric oxide (NO) levels. The aims of these studies were to examine whether NO donor compounds will decrease inflammation and extracellular matrix destruction and simultaneously improve collagen production and wound healing. Specifically, we examined the effects of NO donors NOR-3 and SNOG on expression of matrix metalloproteinases (MMP)-1, -2. -8, -9 and -13, the inflammatory mediator interleukin-6 and collagen types I and type III by normal and diabetic fibroblasts under both normoxic and hypoxic states.
Polarization-independent broadband beam combining grating with over 98% measured diffraction efficiency from 1023 to 1080  nm (2017)

We report a grating solution for achieving broadband and polarization-independent properties that brings a laser combining system to much higher power levels. The grating, with a high-refractive-index-contrast bilayer ridge, was designed and successfully fabricated based on high-power laser coatings, lithography, and ion-beam etching technology. The measured &#x2212;1st order non-polarized reflective diffraction efficiency of the grating exceeds 98% over the wavelength range of 1.023&#x2013;1.08&#x00A0;&#x03BC;m, and the highest value is 99.15%.
Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling (2019)

T cells are thought to discriminate self from foreign peptides by converting small differences in ligand binding half-life into large changes in cell signaling. Such a kinetic proofreading model has been difficult to test directly, as existing methods of altering ligand binding half-life also change other potentially important biophysical parameters, most notably the mechanical stability of the receptor-ligand interaction. Here we develop an optogenetic approach to specifically tune the binding half-life of a chimeric antigen receptor without changing other binding parameters and provide direct evidence of kinetic proofreading in T cell signaling. This half-life discrimination is executed in the proximal signaling pathway, downstream of ZAP70 recruitment and upstream of diacylglycerol accumulation. Our methods represent a general tool for temporal and spatial control of T cell signaling and extend the reach of optogenetics to probe pathways where the individual molecular kinetics, rather than the ensemble average, gates downstream signaling.
Ultrahigh peak power with femtosecond excimer lasers (1986)

Recently, a new experimental regime, in which the optical field strength E is considerably greater than an atomic unit <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="eq1" display="inline"> <mml:mrow> <mml:mrow> <mml:mo>(</mml:mo> <mml:mrow> <mml:mi>e</mml:mi> <mml:mo>/</mml:mo> <mml:msubsup> <mml:mi>a</mml:mi> <mml:mn>0</mml:mn> <mml:mn>2</mml:mn> </mml:msubsup> </mml:mrow> <mml:mo>)</mml:mo> </mml:mrow> </mml:mrow> </mml:math> , has become open for systematic study. Indeed, electric field strengths of the order of 100 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="eq2" display="inline"> <mml:mrow> <mml:mrow> <mml:mo>(</mml:mo> <mml:mrow> <mml:mi>e</mml:mi> <mml:mo>/</mml:mo> <mml:msubsup> <mml:mi>a</mml:mi> <mml:mn>0</mml:mn> <mml:mn>2</mml:mn> </mml:msubsup> </mml:mrow> <mml:mo>)</mml:mo> </mml:mrow> </mml:mrow> </mml:math> should be attainable. This extraordinary range of field strengths has become accessible principally because of the availability of an ultraviolet laser technology capable of producing subpicosecond pulses with energies approaching the joule level in low divergence beams at high repetition rates. Clearly, a technology of this genre will make possible the creation of physical conditions unachievable with any other known experimental means.
Association between Common Variants near LBX1 and Adolescent Idiopathic Scoliosis Replicated in the Chinese Han Population (2013)

This study shows that the genetic variants near the LBX1 gene are associated with AIS susceptibility in Chinese Han population. It successfully replicates the results of the GWAS, which was performed in a Japanese population.
Expression and immunogenicity of the entire human T cell leukaemia virus type I envelope protein produced in a baculovirus system (1993)

The entire envelope gene of human T cell leukaemia virus type I (HTLV-I) has been successfully expressed in a baculovirus non-fusion vector system. The HTLV-I envelope protein accumulated within the insect cells as inclusion bodies which allowed efficient recovery of the recombinant protein. In an attempt to study the role of the HTLV-I envelope glycoprotein as an immunogenic target, mice were immunized with the envelope protein inclusion bodies (env-I.B.) in the presence or absence of an adjuvant. Antibodies of broad specificity were produced against the HTLV-I envelope protein in the presence or absence of an adjuvant as detected by Western blotting, radioimmunoprecipitation and peptide ELISA. Neutralizing antibody was detected when env-I.B. immunizations were carried out in the presence of high doses of a new adjuvant composed of a mycobacterial cell wall extract. In a combined immunization regimen, env-I.B. were found to enhance and broaden the antibody response to the HTLV-I envelope glycoprotein, following priming with various recombinant vaccinia virus (RVV) constructs expressing either the entire native HTLV-I envelope (gp46 and gp21) or just the surface envelope protein (gp46). Increased titres of neutralizing antibodies were observed following priming with the RVV expressing gp46 only. Results indicate that immunization regimens that involve priming with RVV expressing HTLV-I envelope followed by boosting with recombinant baculoviral HTLV-I envelope might be useful in eliciting protective immune responses in vivo.
Osbpl8 Deficiency in Mouse Causes an Elevation of High-Density Lipoproteins and Gender-Specific Alterations of Lipid Metabolism (2013)

OSBP-related protein 8 (ORP8) encoded by Osbpl8 is an endoplasmic reticulum sterol sensor implicated in cellular lipid metabolism. We generated an Osbpl8(-/-) (KO) C57Bl/6 mouse strain. Wild-type and Osbpl8KO animals at the age of 13-weeks were fed for 5 weeks either chow or high-fat diet, and their plasma lipids/lipoproteins and hepatic lipids were analyzed. The chow-fed Osbpl8KO male mice showed a marked elevation of high-density lipoprotein (HDL) cholesterol (+79%) and phospholipids (+35%), while only minor increase of apolipoprotein A-I (apoA-I) was detected. In chow-fed female KO mice a less prominent increase of HDL cholesterol (+27%) was observed, while on western diet the HDL increment was prominent in both genders. The HDL increase was accompanied by an elevated level of HDL-associated apolipoprotein E in male, but not female KO animals. No differences between genotypes were observed in lecithin:cholesterol acyltransferase (LCAT) or hepatic lipase (HL) activity, or in the fractional catabolic rate of fluorescently labeled mouse HDL injected in chow-diet fed animals. The Osbpl8KO mice of both genders displayed reduced phospholipid transfer protein (PLTP) activity, but only on chow diet. These findings are consistent with a model in which Osbpl8 deficiency results in altered biosynthesis of HDL. Consistent with this hypothesis, ORP8 depleted mouse hepatocytes secreted an increased amount of nascent HDL into the culture medium. In addition to the HDL phenotype, distinct gender-specific alterations in lipid metabolism were detected: Female KO animals on chow diet showed reduced lipoprotein lipase (LPL) activity and increased plasma triglycerides, while the male KO mice displayed elevated plasma cholesterol biosynthetic markers cholestenol, desmosterol, and lathosterol. Moreover, modest gender-specific alterations in the hepatic expression of lipid homeostatic genes were observed. In conclusion, we report the first viable OsbplKO mouse model, demonstrating a HDL elevating effect of Osbpl8 knock-out and additional gender- and/or diet-dependent impacts on lipid metabolism.
Basophil hypersensitivity response in rabbits (1977)

A cutaneous basophil hypersensitivity response has been observed in rabbits immunized with bovine serum albumin and challenged intradermally with this antigen 7 days later. The cellular response appears to be similar to cutaneous basophil hypersensitivity reported in guinea pigs and humans. A basophil response was also observed in rabbits immunized with Staphylococcus aureus and challenged with viable staphylococcal cells 7 days later. A method of observing basophil infiltration in rabbits by means of connective tissue spreads obtained from the subcutaneous connective tissue is described. The rabbit should serve as an excellent model for the study of basophil responses as these animals have a significant basophil component with few if any tissue mast cells which may be confused both morphologically and functionally with the basophil.
Low-voltage organic transistors on a polymer substrate with an aluminum foil gate fabricated by a laminating and electropolishing process (2006)

The authors report flexible and low-voltage pentacene organic field-effect transistors (OFETs) constructed with an aluminum foil gate electrode, which was fabricated by the simple and low-cost roll-to-roll lamination process. Electropolishing the surface of laminated aluminum foil and spin coating it with an additional thin polymer film resulted in a gate dielectric surface with a root-mean-square roughness of about 0.85nm. These pentacene OFETs with a poly(α-methylstyrene)/anodized Al2O3 dual-layered gate dielectric exhibit a mobility of 0.52cm2∕Vs, an on-off ratio of 105, a subthreshold swing of 317mV/decade, and little hysteresis when operating at −5V.
Computer-Assisted Videokeratography of Corneal Topography After Radial Keratotomy (1991)

We used computer-assisted videokeratography to compare the topographies of 32 corneas from 23 subjects after radial keratotomy with those of 47 normal corneas from 47 subjects controlled for age and preoperative keratometric and refractive power. Three ophthalmologists independently classified color-coded videokeratographs based on the color-coded pattern of dioptric power distribution and the cross-sectional shape. Corneas that had radial keratotomy exhibited a polygonal pattern not seen in normal eyes; this occurred in 59% of corneas. All normal corneas demonstrated a cross-sectional shape configuration that was steeper centrally than peripherally; 79% of corneas after radial keratotomy had a shape that was flatter centrally than peripherally. After radial keratotomy, the dioptric power increased from the center to the periphery (radius of approximately 4.6 mm) by 2.8 +/- 2.2 diopters (mean +/- SD), with a sharp inflection zone ("paracentral knee") 2.7 mm from the center; normal corneas showed a smooth decrease in power from the center to the periphery of 1.9 +/- 0.5 diopters.
Studies on Novel Bacterial Translocase I Inhibitors, A-500359s. III. Deaminocaprolactam Derivatives of Capuramycin: A-500359 E, F, H, M-1 and M-2. (2003)

Novel derivatives of capuramycin were obtained when 10 mM of 2-aminoethyl-L-cysteine (AEC), an inhibitor of aspartokinase, was added to the culture of Streptomyces griseus SANK 60196, the producer of A-500359. They were purified from the culture filtrate and their chemical structures were elucidated as a deaminocaprolactam derivative of capuramycin designated as A-500359 F, A-500359 E, a methyl ester of A-500359 F, and A-500359 H, a 3'-demethyl derivative of A-500359 F. Two other compounds, A-500359 M-1 and A-500359 M-2, were purified from the same medium and their structures were elucidated. A-500359 E, F, H, M-1 and M-2 inhibited bacterial translocase I with an IC50 of 0.027 microM, 1.1 microM, 0.008 microM, 0.058 microM and 0.010 microM, respectively. A-500359 E, M-1 and M-2 inhibited the growth of mycobacteria as well.
Exploring the Synthesis of a New Group of Chiral Ammonium Salts with Specific Configurations at the Stereogenic Nitrogen Centers (2014)

A group of new chiral dications with a fixed, specific configuration at the stereogenic nitrogen center was created. Stereoselective synthesis and recrystallization give the diastereomerically and enantiomerically pure dications, including a chiral amphiphile with surface-active properties.
Bright Ion Channels and Lipid Bilayers (2013)

If we look at a simple organism such as a zebrafish under a microscope, we would see many cells working in harmony. If we zoomed in, we would observe each unit performing its own tasks in a special aqueous environment isolated from the other units by a lipid bilayer approximately 5 nm thick. These confined units are social: they communicate with one another by sensing and responding to the chemical changes in their environment through receptors and ion channels. These channels control the highly specific and selective passage of ions from one side of the cell to the other and are embedded in lipid bilayers. The movement of ions through ion channels supports excitation and electrical signaling in the nervous system. Ion channels have fascinated scientists not only because of their specificity and selectivity, but also for their functions, the serious consequences when they malfunction, and the other potential applications of these molecules. Light is a useful trigger to control and manipulate ion channels externally. With the many state-of-the-art optical technologies available, light offers a high degree of spatial and temporal control, millisecond precision, and noninvasive intervention and does not change the chemical environment of the system of interest. In this Account, we discuss research toward the dynamic control of lipid bilayer assembly and channel function, particularly the transport across the lipid bilayer-ion channel barrier of cells using light. We first summarize the manipulation of ion channel activity with light to modulate the channel's natural activity. Based on the type of photoswitch employed, we can achieve novel functionalities with these channels, and control neural activity. Then we discuss the recent developments in light-induced transport through lipid bilayers. We focus on three different approaches: the incorporation of photoswitchable copolymers into the lipids, the doping of the lipid bilayer with photosensitive amphiphiles and the preparation of the lipid bilayers solely from photoswitchable lipids. These examples reflect the versatility of what we can achieve by manipulating biological systems with light, from triggering the permeability of a specific area of a lipid bilayer to controlling the behavior of a whole organism.
MPEG compliance bitstream design (2005)

A method is described for designing bitstreams that can be used to test MPEG decoders without requiring prior knowledge of the particular circuit implementation. Visual inspection of the video output is used to evaluate the tests.