gebhart/patrepeval huggingface dataset:
Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs (2016)

P450s in the human brain were originally considered unlikely to contribute significantly to the clearance of drugs and other xenobiotic chemicals, since their overall expression was a small fraction of that found in the liver. However, it is now recognized that P450s play substantial roles in the metabolism of both exogenous and endogenous chemicals in the brain, but in a highly cell type- and region-specific manner, in line with the greater functional heterogeneity of the brain compared to the liver. Studies of brain P450 expression and the characterization of the catalytic activity of specific forms expressed as recombinant enzymes have suggested possible roles for xenobiotic-metabolizing P450s in the brain. It is now possible to confirm these roles through the use of intracerebroventricular administration of selective P450 inhibitors in animal models, coupled with brain sampling techniques to measure drug concentrations in vivo, and modern neuroimaging techniques. The purpose of this review is to discuss the evidence behind the functional importance of P450s from the "xenobiotic-metabolizing" families, CYP1, CYP2 and CYP3 in the brain. Approaches used to define the quantitative and qualitative significance of these P450s in determining tissue-specific levels of xenobiotics in brain will be considered. Finally, the possible roles of these enzymes in brain biochemistry will be examined in light of the demonstrated activity of these enzymes in vitro and the association of particular P450 forms with disease states.
A Low-Rank Matrix Approach for the Analysis of Large Amounts of Power System Synchrophasor Data (2015)

With the installation of many new multi-channel phasor measurement units (PMUs), utilities and power grid operators are collecting an unprecedented amount of high-sampling rate bus frequency, bus voltage phasor, and line current phasor data with accurate time stamps. The data owners are interested in efficient algorithms to process and extract as much information as possible from such data for real-time and off-line analysis. Traditional data analysis typically analyze one channel of PMU data at a time, and then combine the results from the individual analysis to arrive at some conclusions. In this paper, a spatial-temporal framework for efficient processing of blocks of PMU data is proposed. A key property of these PMU data matrices is that they are low rank. Using this property, various data management issues such as data compression, missing data recovery, data substitution detection, and disturbance triggering and location can be processing using singular-value based algorithms and convex programming. These functions are illustrated using some historical data from the Central New York power system.
Freeform fabrication of zinc‐air batteries and electromechanical assemblies (2004)

This paper reports on a fabrication platform and extensions to deposition‐based processes that permit freeform fabrication of three‐dimensional functional assemblies with embedded conductive wiring and power sources. Structure and joints are produced by fused deposition of thermoplastics and deposition of elastomers. Conductive wiring is achieved by deposition of various low‐melting‐point alloys and conductive pastes. Batteries based on zinc‐air chemistry are produced by the deposition of zinc, electrolyte, and catalysts, with separator media and electrodes. Details of the deposition processes are provided and several printed assemblies are demonstrated.
Admission Control in Power Constrained OFDM/TDMA Wireless Mesh Networks (2006)

We investigate connection-level, packet-level, and energysaving performances in a power constrained (e.g., solar-powered) OFDM/TDMA wireless mesh network. When a mesh router goes to the sleep mode to reduce energy consumption, packet-level performances (as observed by a mesh client) will be degraded since in sleep mode, a mesh router can neither receive nor transmit packets. An analytical model is developed to analyze the relationship among the packet-level and the connection-level performances. Based on the analytical model, the system performance is analyzed in terms of system utility. To this end, an optimization problem is formulated by using a Markov decision process to choose the optimal policy on sleep management and maximum number of admissible connections at a mesh router so that the system utility is maximized.
Vom Paukenröhrchen zum Koronarstent in zwei Monaten. Die rapide Progression einer Granulomatose mit Polyangiitis (GPA) bei einem siebzehnjährigen Patienten. Ein Fallbericht (2020)

Die Granulomatose mit Polyangiitis (GPA) ist eine nekrotisierende Kleingefäßvaskulitis, die in vielen Fällen mit ersten Symptomen im Kopf-Hals-Bereich einhergeht. Die Kombination aus der Seltenheit der Erkrankung und der Gefahr einer schnellen Progression zu einem lebensbedrohlichen Krankheitszustand bedeutet eine Herausforderung für den HNO-Arzt.
Influence of Dynamic Stiffness in Contact Region on Disk Brake Squeal (2009)

The squeal generation mechanism in disk brakes is clarified by measuring the stiffness between the disk and pad in the contact region (contact stiffness) and performing an analysis using the surface contact analysis model. The results of a squeal test using a squeal testing machine with a simple structure show that the squeal frequency becomes higher as the thrust pressure for braking becomes larger. Since we thought that the contact stiffness depends on the thrust pressure and influences the squeal frequency because the vibration characteristics of the disk do not change with thrust pressure, we measured the contact stiffness under squeal generating conditions. The pad was given constant pressure and excitation force generated by random noise with the squeal bandwidth. Measurement results show that the contact stiffness depends on the thrust pressure and is different for each pad. To clarify the influence of contact stiffness on squeal, the disk-pad-caliper system was analyzed by using the surface contact analysis model, which connects the disk with the pad via distributed springs (contact stiffness). The analytical results show that squeal is easily generated and its frequency easily changes when the dependence of contact stiffness on thrust pressure is large.
Absence of Host Cation Segregation in the (Gd,Y)3Al5O12 Mixed Garnet Optical Ceramics (2011)

Recently non-uniform distribution of dopants in transparent optical ceramics was observed. It was demonstrated that dopants with low segregation coefficients ( K &lt;0.2) with respect to the melt crystal growth are segregated to the grain boundaries when the grains of the ceramics are developed. This communication discusses segregation of host cations that form crystal matrix. Experimental examination of spatial distribution of Gd 3+ and Y 3+ host cations in Ce 3+ -doped (Gd,Y) 3 Al 5 O 12 ceramic sample demonstrated that no detectable redistribution of Gd 3+ and Y 3+ cations in the vicinity of the grain boundaries was detected. These results are in good agreement with comparable segregation behavior of Gd 3+ and Y 3+ [ K (Y 3+ )≈ K (Gd 3+ )] when the garnet solidification is performed from liquid phase. This observation also confirms qualitative match of segregation in liquid and solid states.
Temporal GIS for information collection system using robot technology in a damaged building (2008)

Our research mission is an implementation of mobile robot based disaster information collection system in a preparatory step for rescue activity. In our mission we assume that there is a damaged building or an underground space with some doors and stairs in disaster or terrorism stricken area as a target space. In this paper we discussed demands and technology on GIS as a base system for our proposal.
Yaequinolones J1 and J2, Novel Insecticidal Antibiotics from Penicillium sp. FKI-2140 (2005)

[chemical reaction: see text]. Two novel insecticidal antibiotics with a p-methoxyphenylquinolinone skeleton fused with a pyran ring, yaequinolones J1 (1) and J2 (2), have been isolated from Penicillium sp. FKI-2140, and structures were elucidated by spectroscopic studies including various NMR experiments. The relative stereochemistries were assigned by NOE experiments. Yaequinolones J1 and J2 showed toxicity against Artemia salina (brine shrimp) with the MIC value of 6.25 microg/mL.
Efficient Spare Allocation for Reconfigurable Arrays (1987)

Yield degradation from physical failures in large memories and processor arrays is of significant concern to semiconductor manufacturers. One method of increasing the yield for iterated arrays of memory cells or processing elements is to incorporate spare rows and columns in the die or wafer. These spare rows and columns can then be programmed into the array. The authors discuss the use of CAD approaches to reconfigure such arrays. The complexity of optimal reconfiguration is shown to be NP-complete. The authors present two algorithms for spare allocation that are based on graph-theoretic analysis. The first uses a branch-and-bound approach with early screening based on bipartite graph matching. The second is an efficient polynomial time-approximation algorithm. In contrast to existing greedy and exhaustive search algorithms, these algorithms provide highly efficient and flexible reconfiguration analysis.
Assessment of Cancellous Bone Architecture after Implantation of an Injectable Bone Substitute (2003)

International audience
Thickening of ultrafine coal-water slurries in a solid-bowl centrifuge (1999)

As part of a study being conducted for the Electric Power Research Institute's (EPRI's) Upgraded Coal Interest Group (UCIG) to evaluate ultrafine coal dewatering technologies, testing was carried out to investigate the use of a solid-bowl (high-g) centrifuge for thickening ultrafine coalwater slurries. The objective of this study was to increase the solids concentration to a level suitable for use as a coal-water slurry fuel, while maximizing overall solids recovery. Feed material was collected from the combined discharge (centrate) streams from several screen-bowl centrifuges. These devices are currently being used in a commercial coal cleaning facility to dewater the clean coal product from a froth flotation circuit. Current plant practice is to discharge the centrate to settling ponds. The screen bowl centrate averages 5% solids by weight and contains nearly 60% material finer than 10 {mu}m. The current study examined the effects of operating conditions on centrifuge performance. The test conditions included centrifuge bowl and scroll speeds and volumetric feed rate. In addition to thickening, some cleaning was also achieved, because the finest particles (e.g. < 3 {micro}m), which contained a large percentage of liberated clays, were removed with the bulk of the water. The centrifuge products were analyzed formore » solids concentration, particle size distribution, and ash content. Size selectivity curves were also used to evaluate centrifuge performance.« less
Energy Spectra Between 10 and Several Hundred GeV/Nucleon for Elements from _(18)Ar to _(23)V: Results from HEAO-3 (1990)

We report updates of recently published results on cosmic ray energy spectra of the sub-iron&#13;\nnuclei. This paper is based on the following analysis and improvements : a) a better analysis of&#13;\nthe charge resolution of the instrument, b) availability of more recent charge-changing cross&#13;\nsections necessary to correct the abundances for interactions inside the detector, and c) a recent revision of the results from the French-Danish C2 experiment on HEA0-3 that were included in&#13;\nour analysis.
Detection of Streptococcus Species by Polymerase Chain Reaction in Infectious Crystalline Keratopathy (2006)

Our findings suggest that PCR provides a good adjunct technique in the diagnosis of corneal infection.
All-sky search for long-duration gravitational wave transients in the first Advanced LIGO observing run (2018)

We present the results of a search for long-duration gravitational wave transients in the data of the LIGO Hanford and LIGO Livingston second generation detectors between September 2015 and January 2016, with a total observational time of 49 days. The search targets gravitational wave transients of 10 – 500 s duration in a frequency band of 24 – 2048 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. No significant events were observed. As a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. We also show that thesearch is sensitive to sources in the Galaxy emitting at least ∼ 10−8 M⊙c2 in gravitational waves.
Comparison of total phenolic content and antioxidant activities of freeze-dried commercial and fresh fruit juices (2012)

Fruits contain various natural antioxidants and secondary metabolites which play an important role in human health. Fruit juices have been proposed as a convenient substitute for fresh fruit. In this study, the total phenolic content and antioxidant activity of various freeze-dried fresh fruit blends or fruit juices (Apple, lime, guava, mango, orange) were compared. Total phenolic content of the extracts was determined using Folin-Ciocalteu assay. Antioxidant capacity of the extracts was determined by 1,1-diphenyl-2picryl hydrazyl (DPPH) scavenging assay and tyrosinase inhibition assay. Guava contained the highest amount of total phenolic content among all the tested fresh fruit blend, while mango contained the highest amount of total phenolic content for the commercial fruit juice. Apple contained the lowest content of total phenolic in both fresh and commercial fruit juice. In the DPPH scavenging test, guava and mango still possessed the strongest antioxidant activity for fresh and commercial fruit juices. Commercial lime juice possessed the weakest antioxidant activity where no IC50 was able to obtain even up to 10 mg/ml. All of the commercial and fresh fruit did not show tyrosinase inhibition activity. The present study demonstrates the potential value of commercial fruit juice as the replacement of fresh fruit. However, only commercial mango and orange juices were able to maintain similar antioxidant activity and total phenolic content as fresh fruit.

	 

	Key words: Fruit juices, 1,1-diphenyl-2picryl hydrazyl (DPPH), tyrosinase inhibition activity.
Abstract 16905: Association of Triglycerides With Mortality across CKD Stages in Over 1.3 Million US Veterans (2017)

Introduction: Prior studies have shown that high serum triglycerides (TG) levels are associated with worse survival in the general population. However, it is unknown if this TG and mortality associ...
In-silico modelling and identification of a possible inhibitor of H1N1 virus (2014)

To find the neuraminidase H1N1 inhibition potential of 4-hydroxypanduratin A and its derivatives along with associated binding mechanism through virtual screening and molecular docking. Initially, the structural templates for neuraminidase proteins were identified from structural database using homology search and performed homology and ab initio modeling to predict native 3D structure using Modeller 9.10 and I-TASSER server, respectively. The reliability of the three-dimensional models was validated using Ramachandran plot. The molecular docking was performed using Autodcok 4.2 and molecular interactions were analyzed through PyMol, Chimera and LigPlot. The neuraminidase protein sequences of ADH29478, ADD85918, AEM62864 (2009) and AFO38701 (2011) from India were modeled and validated. 4-hydroxypanduratin A and its 88 derivatives were docked in to active binding pockets of neuraminidase. The guanidine group of residues Arg152 and Trp179 of ADH29478 (Chennai) and AFO38701 (Gwalior) neuraminidase models present in the hydrophilic domain (-OH and =O groups) was found to have molecular interactions with high binding affinities of −7.40 kcal/mol and −8.66 kcal/mol, respectively to 1-(2,4-dihydroxyphenyl)-3,3-diphenylpropan-1-one (CID: 19875815) than other FDA approved drugs such as oseltamivir, zana-mivir, and peramivir. 1-(2,4-dihydroxyphenyl)-3,3-diphenylpropan-1-one will be a breakthrough for further drug development against swine flu.
Is Geology a Real Science? (2012)

English geologist, paleontologist, and Dean of Westminster, recognized geology as an intellectual endeavore and a real science; a science with much to offer in understanding nature.But, we are now in the 21 st century and viewpoints have changed.Better educated (?), more enlightened (?) bean counters and high-level academics feel otherwise.In the last issue of The Compass I bemoaned the closure of the Geology program at the University of Northern Iowa (Davis, 2012).I still strongly believe the closure is a bad idea, but I also sense the the closure is a symptom of a larger issue.Geologists, and geology as a scientific endeavor, are simply not held in very high esteem by many academics or the general public.The message seem to be that geology is not a real science, and, therefore, not really important.I sense a few hackles are being raised at the moment by the readers of this editorial, and this is understandable since most of you are probably geologists.So where did I get this notion?From the TV sitcom The Big Bang Theory, where else?In one episode Sheldon, the nerdy (and very irritating) physicist, proclaims "geology is not a real science".There you have it!The Big Bang Theory is filled with science and mathematics humor and some of the mocking humor is directed at geology and paleontology.I"m a bit thin skinned on such matters.[As an aside, I recently discovered mathematicians don"t like the useage of "math" for mathematics, so be forewarned.Talk about thin skinned!] And, yes, I do watch The Big Bang Theory, but my wife is always careful about making sure my rock hammer is nowhere around because she doesn"t want me throwing it at Sheldon.A number of years ago, my daughter, who wanted to major in psychology, was on a college tour being conducted by a staff member in the Psychology Department.As one might expect from the daughter of a geologist, she asked about taking one or more geology courses to fulfill her core requirements in science.She was quickly told, "not a good idea because geology is not a real science.Furthermore, taking a geology course shows a fear of science."Needless to say she immediately reported back to me and I went to see the Chair of the Geology Department,
Methyl(OXO)Rhenium(V) Complexes with Chelating Ligands (2014)

Methylrhenium(V) oxo compounds with certain chelating ligands are often effective catalysts for oxygen atom transfer reactions. Such rhenium compounds are also chemical relatives of the extensively studied molybdenum and tungsten oxotransferase enzymes. Many methylrhenium(V) oxo compounds are five-coordinate with a square pyramidal geometry about rhenium. This chapter discusses the procedures and properties of methyl(oxo)(1,2-ethanedithiolato)rhenium(V) dimer, methyl(oxo)bis(2-oxyquinoline)rhenium(V), and methyl(oxo)(2,2′-thiodiacetato)(triphenylphosphine) rhenium(V).
Synthesis and Characterization of Ultrafine Poly(vinylalcohol phosphate) Coated Magnetite Nanoparticles (2006)

Nanosized magnetite (Fe3O4) particles showing superparamagnetism at room temperature have been prepared by controlled coprecipitation of Fe2+ and Fe3+ in presence of highly hydrophilic poly(vinylalcohol phosphate)(PVAP). The impact of polymer concentration on particle size, size distribution, colloidal stability, and magnetic property has been extensively studied. The aqueous suspension of magnetite, prepared using 1% PVAP solution is stable for four weeks at pH 5-8. X-ray diffractograms show the formation of nanocrystalline inverse spinel phase magnetite. Transmission Electron Microscopy confirmed well dispersed cubic magnetite particles of size of about 5.8 nm. Dynamic Light Scattering measurement shows narrow distribution of hydrodynamic size of particle aggregates. Infrared spectra of samples show strong Fe--O--P bond on the oxide surface. UV-visible studies show aqueous dispersion of magnetite formed by using 1% PVAP solution is stable at least for four weeks without any detoriation of particle size. Magnetization measurements at room temperature show superparamagnetic nature of polymer coated magnetite nanoparticles.
Optimization of Sulfide/Sulfite Pretreatment of Lignocellulosic Biomass for Lactic Acid Production (2013)

Potential of sodium sulfide and sodium sulfite, in the presence of sodium hydroxide was investigated to pretreat the corncob (CC), bagasse (BG), water hyacinth and rice husk (RH) for maximum digestibility. Response Surface Methodology was employed for the optimization of pretreatment factors such as temperature, time and concentration of Na₂S and Na₂SO₃, which had high coefficient of determination (R²) along with low probability value (P), indicating the reliable predictability of the model. At optimized conditions, Na₂S and Na₂SO₃ remove up to 97% lignin, from WH and RH, along with removal of hemicellulose (up to 93%) during pretreatment providing maximum cellulose, while in BG and CC; 75.0% and 90.0% reduction in lignin and hemicellulose was observed. Saccharification efficiency of RH, WH, BG and CC after treatment with 1.0% Na₂S at 130°C for 2.3-3.0 h was 79.40, 85.93, 87.70, and 88.43%, respectively. WH treated with Na₂SO₃ showed higher hydrolysis yield (86.34%) as compared to Na₂S while other biomass substrates showed 2.0-3.0% less yield with Na₂SO₃. Resulting sugars were evaluated as substrate for lactic acid production, yielding 26.48, 25.36, 31.73, and 30.31 gL⁻¹ of lactic acid with 76.0, 76.0, 86.0, and 83.0% conversion yield from CC, BG, WH, and RH hydrolyzate, respectively.
Neuronal Correlates of Decision Making (2008)

Decision making involves selection from sets of options based on current evidence about the state of the world and estimates of the value or utility of different outcomes. The neural correlates of evidence assessment that guide simple perceptual judgments are now well understood, and we argue that this process can serve as a simple model for organizing behavioral and neural correlates of decision making in more complex contexts, including those that involve economic transactions, social interaction, emotional stimulation, and conscious awareness. Bridging the methodological and theoretical gaps between simple and more complicated decision problems remains a fundamental, but in our view soluble, challenge for understanding the neurobiology of decision making.
Multisource elastic full waveform inversion method for irregular surface (2015)

Summary Full waveform inversion (FWI) is a method of geophysical parameter inversion using seismic data based on full the wave field forward modeling technology, and now has become a efficient tool of velocity modeling and research hot spot. As oil and gas exploration increasingly inclined to complex structure, more geophysicists began to put their effort to the research of irregular surface. Elastic FWI method uses elastic wave equation to replace acoustic wave equation, and inverts multi-parameter rather than only p-velocity. In this paper, a generalized body-fitted grids and coordinate transformation technique are proposed to overcome the problem that the generation of traditional body-fitted grids needs a great amount of calculation. Forward modeling test proves that the generalized body-fitted grids method saves lots of time without losing accurate. We apply the method to irregular surface multi-parameter FWI to propose a time domain elastic multi-parameter full waveform inversion for irregular surface based on generalized body-fitted grids. In order to decrease the computation cost of FWI, an optimized encoding function is proposed and multisource FWI is applied in inverting parameters. Model tests of simple irregular surface depression model and complex irregular model show the accurate and robust of our method.