gebhart/patrepeval huggingface dataset:
User Selection Algorithms for MU-MIMO Systems with Coordinated Beamforming (2015)

In this paper, we propose two novel user selection algorithms for multiuser multiple-input and multipleoutput downlink wireless systems, in which both a base station (BS) and mobile stations (MSs) are equipped with multiple antennas. Linear transmit beamforming at the BS and receive combining at the MSs are used to avoid interference between users and find a better sum-rate capacity performance. An optimal technique for selecting users would entail an exhaustive search, which in practice becomes computationally complex for a realistic number of users. Suboptimal algorithms with low complexity are proposed for a coordinated beamforming scheme. Simulation results show that the performance of the proposed algorithms is better than that provided by previous algorithms and is very close to an optimal approach with reduced complexity.
Human granulocyte colony stimulating factor (hG-CSF): cloning, overexpression, purification and characterization (2008)

The recombinant protein expression in the absence of IPTG induction is advantageous since cost is reduced, and the protein purification protocol using a single chromatographic step should reduce cost even further for large scale production. The physicochemical, immunological and biological analyses showed that this protocol can be useful to develop therapeutic bioproducts. In summary, the combination of different experimental strategies presented here allowed an efficient and cost-effective protocol for rhG-CSF production. These data may be of interest to biopharmaceutical companies interested in developing biosimilars and healthcare community.
Changes in the distribution of cortical myosin during the cellularization of the Drosophila embryo (1980)

Changes in the distribution of myosin during the formation of the cellular blastoderm of Drosophila melanogaster were followed by staining sections of embryos with antibodies to myosin. These were visualized with indirect immunofluorescence. Prior to the start of cell membrane extension myosin is distributed between the nuclear caps as a thin sub-plasmalemma layer. There is also myosin present beneath the surface of the caps. When plasmalemma growth occurs, myosin is associated with the furrow canals, the tips of the advancing membranes. The fluorescence is distributed in an approximately hexagonal pattern around the growth points of each cell. The hexagons are joined up forming a network. It is suggested that this myosin is associated with bundles of microfilaments, orientated parallel to the surface, to form many interlocking contractile rings. The simultaneous contraction of these rings causes the cleavage of the blastoderm. During the first phase of membrane growth, myosin is also associated with the apical surfaces of the forming cells. At this stage these surfaces are rich in microvilli. However, by the time the furrow canals have reached the bases of the cells much of this myosin has disappeared. At about this time the apical surface becomes taut with a loss of the microvilli.
Neotype Strain of Zoogloea ramigera Itzigsohn: Request for an Opinion (1971)

The neotype strain of Zoogloea ramigera Itzigsohn is strain I-16-M (= ATCC 19623 = NCIB 10340 = NCTC 10482). However, this strain is not suitable as a neotype, primarily because of its inability to form the true zoogloeas cited by Itzigsohn in his original description of this organism. It is requested, therefore, that the Judicial Commission issue an Opinion rejecting strain I-16-M as the neotype of Z. ramigera and replacing it with strain 106 (= ATCC 19544).
Large grain polycrystalline silicon by low-temperature annealing of low-pressure chemical vapor deposited amorphous silicon films (1988)

The crystallization of undoped amorphous silicon films deposited by low-pressure chemical vapor deposition in the temperature range 580–530 °C and annealed from 550 to 950 °C has been studied by transmission electron microscopy. The average grain size of the crystallized films depends on the annealing temperature and the deposition conditions. The nucleation rate of new grains during annealing decreases as the deposition temperature decreases from 580 to 545 °C and/or when the deposition rate increases. The final grain size is also influenced by the annealing temperature with the largest grain size obtained at low annealing temperatures. A simple model is described which explains the dependence of grain size on the annealing temperature. An average grain size of 500 nm has been obtained in a 200-nm film deposited at 545 °C and annealed at 550 °C.
Optimisation of SuperJunction Bipolar Transistor for ultra-fast switching applications (2007)

In this work we present a thorough optimisation of the superjunction bipolar transistor based on a new modelling approach. The superjunction bipolar transistor was first proposed in (F. Bauer 2004), but its potential against the most advanced IGBT structures such as field stop (FS), light punch-through or trench IGBTs, has only been briefly discussed. For the first time we report here on the impact of varying the net doping of the n and p drift layer pillars to deliver the best trade-off between the on-state and switching performance. This is carried out both at room temperature and high temperatures. In essence the doping charge in the n & p pillars changes the ratio between bipolar and unipolar conduction in the drift region and therefore alters very significantly the speed and on-state performance of the device. This is a unique effect, un-characteristic to any other power devices known in the field. We demonstrate here through extensive numerical simulations that an optimised superjunction IGBT can lower the turn-off losses by a factor of 2 (or more) when compared to a state-of-the-art field stop (soft punch through) IGBT while maintaining a similarly low on-state voltage drop. We also show here that the SJ concept can deliver significantly improved overall performance when compared to a FS IGBT at lower drift dopings, where the use of charge balance results in lower drift lengths and at high doping levels, where the effect of unipolar conduction at the cathode side of the drift region leads to better on-state/switching trade-off. However there is a middle range of doping levels where the use of the SJ drift region is in fact detrimental to the plasma distribution in the device leading to worse performance than a FS IGBT.
Detecting the birth and death of finite-time coherent sets (2021)

Finite-time coherent sets (FTCSs) are distinguished regions of phase space that resist mixing with the surrounding space for some finite period of time; physical manifestations include eddies and vortices in the ocean and atmosphere, respectively. The boundaries of finite-time coherent sets are examples of Lagrangian coherent structures (LCSs). The selection of the time duration over which FTCS and LCS computations are made in practice is crucial to their success. If this time is longer than the lifetime of coherence of individual objects then existing methods will fail to detect the shorter-lived coherence. It is of clear practical interest to determine the full lifetime of coherent objects, but in complicated practical situations, for example a field of ocean eddies with varying lifetimes, this is impossible with existing approaches. Moreover, determining the timing of emergence and destruction of coherent sets is of significant scientific interest. In this work we introduce new constructions to address these issues. The key components are an inflated dynamic Laplace operator and the concept of semi-material FTCSs. We make strong mathematical connections between the inflated dynamic Laplacian and the standard dynamic Laplacian [Froyland 2015], showing that the latter arises as a limit of the former. The spectrum and eigenfunctions of the inflated dynamic Laplacian directly provide information on the number, lifetimes, and evolution of coherent~sets.
Zinc inhibition of renin and the protease from human immunodeficiency virus type 1 (1991)

We report here for the first time that Zn2+ is an effective inhibitor of renin and the protease from HIV-1, two aspartyl proteinases of considerable physiological importance. Inhibition of renin is noncompetitive and is accompanied by binding of 1 mol of Zn2+/mol of enzyme. Depending on the substrate, inhibition of the HIV protease by Zn2+ can be either competitive or noncompetitive, but in neither case is loss of activity due to disruption of the protease dimer. Inhibition of both enzymes is first order with respect to Zn2+ and is rapidly reversed by addition of EDTA. Ki values are strongly pH dependent and optimal in the range of 20 microM at or above pH 7. All of the data in hand suggest that the inhibitory effect of Zn2+ is a consequence of its binding at, or near, the active-site carboxyl groups of these aspartyl proteinases. This inhibition of the viral enzyme may help to explain some of the beneficial effects seen in AIDS patients who have received Zn2+ therapy.
Abstract 5606: Fibrinogen-like protein 2 drives malignant tumor progression in glioma (2017)

Abstract Gliomas are the most common type of brain tumor in both children and adults. Several low-grade gliomas (LGG) have the ability to progress into more aggressive tumors -high-grade gliomas (HGG) including glioblastoma (GB). Although patients harboring a LGG may survive for years, after the tumor transforms to HGG, life expectancy rapidly declines to 12 to 15 months in adults and 40 months in children. Thus, inhibiting this process of malignant transformation (MT) is an attractive therapeutic strategy because of the more indolent course associated with LGGs. Immune response plays a critical role in surveillance against malignant transformation. Our previous study shows that fibrinogen-like protein 2 (FGL2) is a key hub of tumor-mediated immune suppression. Hence, we investigated the role of FGL2 in promoting tumor progression from LGG to HGG in glioma. Analysis of TCGA expression data showed that increased FGL2 expression is associated with poorer survival in LGG and GB patients. And there is a positive correlation of expression level between FGL2 and mesenchymal glioma marker CD44, and a negative correlation between FGL2 and proneural glioma marker OLIG2. Engineered expression of FGL2 in a PDGFB-dependent mouse model of oligodendroglioma, a common glioma subtype, yielded a significantly higher rate of HGGs (72% vs 29%, p=0.034) and poorer-symptom free survival (63 vs 90 days, p=0.003) than PDGFB expression alone. And HGGs from FGL2 + PDGFB expressing mice exhibited a distinct mesenchymal phenotype validating TCGA data. Further, FGL2 induced high numbers of CD4+FoxP3+ cells from an early time point of tumor formation underscoring its role in tumor progression. And FGL2 overexpression educated M2 skew in the tumors characterized by high expression of Iba1 and Arginase1 in macrophages. Finally, treatment with anti-FGL2 antibody significantly improves survival in mice, shifts the phenotype from mesenchymal HGG to proneural LGG, and rescues M2 macrophage skewing. Our results show that FGL2 is critical for malignant progression of glioma by inducing immunosuppression in tumor microenvironment, and raise the potential of FGL2 to be a promising target to suppress/reverse glioma progression and provide survival benefit in clinical. Citation Format: Khatri Latha, Jun Yan, Yuhui Yang, Loyola V. Gressot, Lingyuan Kong, Ganiraju Manyam, Ravesanker Ezhilarasan, Qianghu Wang, Erik P. Sulman, Jingda Xu, Richard E. Davis, Suyun Huang, Gregory N. Fuller, Arvind Rao, Amy B. Heimberger, Shulin Li, Ganesh Rao. Fibrinogen-like protein 2 drives malignant tumor progression in glioma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5606. doi:10.1158/1538-7445.AM2017-5606
Autologous Hematologic Recovery from Aplastic Anemia following High Dose Cyclophosphamide and HLA-Matched Allogeneic Bone Marrow Transplantation (1979)

A 17-year-old woman with severe aplastic anemia was treated with high-dose cyclophosphamide followed by infusion of bone marrow cells from her HLA-identical, ABO-incompatible brother. The marrow graft failed to take. Subsequently, the patient revealed an autologous marrow reconstitution leading to a near-complete hematologic recovery which is now persisting for over 20 months.
Evoked potentials as a translatable biomarker to track functional remyelination (2019)

Enhancing remyelination is a key therapeutic strategy for demyelinating diseases such as multiple sclerosis. To achieve this goal, a central challenge is being able to quantitatively and longitudinally track functional remyelination, especially with translatable biomarkers that can be performed in both preclinical models and in the clinic. We developed the methodology to stably measure multi-modal sensory evoked potentials from the skull surface over the course of months in individual mice and applied it to a genetic mouse model of oligodendrocyte ablation and demyelination. We found that auditory and somatosensory evoked potential latencies reliably increased over time during the early phase of the model and recovered spontaneously and almost completely during a later phase. Histological examination supported the interpretation that the evoked potential latency changes dynamically reflect changes in CNS myelination. Specifically, we found reduction of myelination in corresponding brain regions at the time that sensory evoked potentials were maximally impacted. Importantly, we also found that myelination levels recovered when evoked potential latencies recovered. Other changes known to associate with demyelination were also observed at the time of delayed evoked potentials, including the emergence of white matter vacuoles and increased markers for activated microglia and macrophages; these changes also fully reversed by the time that evoked potentials recovered. Our results support the hypothesis that skull-surface recorded evoked potential latencies can dynamically track CNS myelination changes. The methods developed here allow for longitudinally tracking functional myelination changes in vivo in preclinical rodent models with a quantitative biomarker that can also be applied clinically and will facilitate translational development of CNS remyelinating therapies.
Cold weather and risk of sudden cardiac death in schizophrenia: finding a new Achilles' heel? (2008)

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Relationship between amino acid composition and gene expression in the mouse genome (2011)

These results suggest that it is difficult to predict expression level from amino acid components or from codon bias in mouse.
Isomeric cationic ionenes as n-dopant agents of poly(3,4-ethylenedioxythiophene) for in situ gelation (2018)

Three isomeric ionene polymers containing 1,4-diazabicyclo[2.2.2]octane (DABCO) and N,N'-(x-phenylene)dibenzamide (x = ortho-/meta-/para-) linkages have been used as dopant agents to produce n-doped poly(3,4-ethylenedioxythiophene) (PEDOT) electrodes by reducing already dedoped conducting polymer (CP) films. This work focuses on the influence of the ionene topology on both the properties of n-doped PEDOT:ionene electrodes and the success of the in situ thermal gelation of the ionene inside the CP matrix. The highest doping level is reached for the para-isomeric ionene-containing electrode, even though the content of ortho- and meta-topomers in the corresponding n-doped PEDOT:ionene electrodes is greater. Thus, many of the incorporated ionene units are not directly interacting with CP chains and, therefore, they do not play an active role as n-dopant agents but they are crucial for the in situ formation of the ionene hydrogels. The effect of the ionene topology is practically non-existent on properties such as the specific capacitance and wettability of PEDOT:ionene films, and it is small but non-negligible on the electrochemical and thermal stability. In contrast, the surface morphology, topography, and distribution of dopant molecules significantly depend on the ionene topology. In situ thermal gelation was successful in PEDOT films n-doped with the ortho- and para-topomers, even though this assembly process was much faster for the former than for the latter. The gelation considerably improved the mechanical response of the electropolymerized PEDOT film, which was practically non-existent before it. Molecular dynamics simulations prove that the strength and abundance of PEDOTionene specific interactions (i.e. π-π stacking, N-HS hydrogen bonds and both N+O and N+S interactions) are higher for the meta-isomeric ionene, for which the in situ gelation was not achieved, than for the ortho- and para-ones.
Patron Preferences for Features Offered by Licensed Clubs (1993)

Licensed clubs in Australia offer a range of types of hospitality, gambling and entertainment. Increased competition is forcing them to reappraise features or attributes of their products in order to ensure that they are marketing the right mix of features to their patrons, both club members and visitors. Uses conjoint analysis in order to examine the utility obtained by patrons from alternative types of food and beverage service, gambling and entertainment at two major clubs. The study indicates value differences between clubs, and between patron groups, providing a basis for segmentation. The findings lead to indicators for club marketing strategy.
Object Detection in Images by Components (1999)

In this paper we present a component based person detection system that is capable of detecting frontal, rear and near side views of people, and partially occluded persons in cluttered scenes. The framework that is described here for people is easily applied to other objects as well. The motivation for developing a component based approach istwofold: rst, to enhance the performance of person detection systems on frontal and rear views of people and second, to develop a framework that directly addresses the problem of detecting people who are partially occluded or whose body parts blend in with the background. The data classi cation is handled by several support vector machine classi ers arranged in two layers. This architecture is known as Adaptive Combination of Classi ers (ACC). The system performs very well and is capable of detecting people even when all components of a person are not found. The performance of the system is signi cantly better than a full body
Lysine carbonylation is a previously unrecognized contributor to peroxidase activation of cytochrome c by chloramine-T (2019)

The peroxidase activity of cytochrome <i>c</i> (cyt <i>c</i>) plays a key role during apoptosis. Peroxidase catalysis requires a vacant Fe coordination site, <i>i.e.</i>, cyt <i>c</i> must undergo an activation process involving structural changes that rupture the native Met80-Fe contact. A common strategy for dissociating this bond is the conversion of Met80 to sulfoxide (MetO). It is widely believed that this MetO formation in itself is sufficient for cyt <i>c</i> activation. This notion originates from studies on chloramine-T-treated cyt <i>c</i> (CT-cyt <i>c</i>) which represents a standard model for the peroxidase activated state. CT-cyt <i>c</i> is considered to be a "clean" species that has undergone selective MetO formation, without any other modifications. Using optical, chromatographic, and mass spectrometry techniques, the current work demonstrates that CT-induced activation of cyt <i>c</i> is more complicated than previously thought. MetO formation alone results in only marginal peroxidase activity, because dissociation of the Met80-Fe bond triggers alternative ligation scenarios where Lys residues interfere with access to the heme. We found that CT causes not only MetO formation, but also carbonylation of several Lys residues. Carbonylation is associated with -1 Da mass shifts that have gone undetected in the CT-cyt <i>c</i> literature. Proteoforms possessing both MetO and Lys carbonylation exhibit almost fourfold higher peroxidase activity than those with MetO alone. Carbonylation abrogates the capability of Lys to coordinate the heme, thereby freeing up the distal site as required for an active peroxidase. Previous studies on CT-cyt <i>c</i> may have inadvertently examined carbonylated proteoforms, potentially misattributing effects of carbonylation to solely MetO formation.
Design of a Lengthening Element for a Modular Femur Endoprosthetic System (1989)

A malignant tumour may develop around the knee joint of a child. In the majority of cases it will then be necessary to resect the involved bone with adjacent tissue. A joint team of Groningen University Hospital and University of Twente is currently working on the project of developing a modular endoprosthetic system to bridge the defect resulting from the resection. Since the other, normal, leg continues to grow, the endoprosthetic system will have to include an element the length of which can be adjusted non-invasively. The main conditions to be met by the lengthening element are non-invasive continuous adjustability and a maximum total lengthening of 114 mm. This was achieved by using an external magnetic field. Animal experiments showed that the lengthening element worked well, although moisture infiltrated the telescopic tubes and the lengthening element was covered by proliferating bone at an early stage. Also, the necessary magnetic field proved to be larger than calculated. In a revised design, these problems are resolved. In vitro tests show that the new lengthening element meets all requirements.
Side-Chain Liquid Crystalline Polymer Networks: Exploiting Nanoscale Smectic Polymorphism To Design Shape-Memory Polymers (2011)

Herein, we investigate the influence of nanoscale smectic polymorphism within end-on fixed side-chain liquid crystalline polymer networks (SCLCNs) on macroscopic shape-memory and actuation properties. We have synthesized a series of SCLC-type linear (TP-n) and cross-linked random terpolymers (XL-TP-n) with varying length of flexible methylene spacers (n = 5, 10, and 15) between polynorbornene main-chain and cholesteryl ester side-chains. Thermal and mechanical analyses by differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) confirm a glass transition (T(g)), a clearing temperature (T(cl)), and a network structure in the XL-TP-n. Detailed structural investigation conducted using wide-angle and small-angle X-ray scattering (WAXS and SAXS) at room temperature proves self-assembled smectic A (SmA) polymorphism of the XL-TP-n which evolves from non-interdigitated bilayer (SmA(2)) for n = 5 to mixed layers of monolayer-like highly interdigitated layer (SmA(1)) and SmA(2) for n = 10 and to SmA(1) for n = 15. In addition, TP10 at temperatures above 60 °C interestingly shows transformation of SmA structure from mixed layer (SmA(1) + SmA(2)) to interdigitated structure (SmA(d)). The SmA polymorphism developed in TP-n during shape-memory cycles (SMCs) significantly impacts the ultimate strain responses. A mechanism for the unique interdigitation-based thermostrictive behavior is proposed. More importantly, this new actuation mechanism observed in these XL-TP-n can be exploited to develop intelligent thermal actuators.