gebhart/patrepeval huggingface dataset:
NMR Study of Rapidly Exchanging Backbone Amide Protons in Staphylococcal Nuclease and the Correlation with Structural and Dynamic Properties (1997)

Exchange rates of rapidly exchanging (>1.0 s-1) backbone amide protons with solvent water in staphylococcal nuclease (SN) were measured at pH 6.03−7.03 with a 2D heteronuclear water exchange filter sequence (WEX II-FHSQC). Comparison of the exchange data with crystal structure data reveals the following: (1) Non-hydrogen-bonding and exposed residues have protection factors (predicted exchange rate in random coil/measured exchange rate) of less than 15 for non-hydrophobic residues and 10 or higher for hydrophobic residues. Among non-hydrophobic residues, Gly tends to have a higher protection factor (10−15), whereas other residues are below 10. (2) Protection factors for buried and non-hydrogen-bonded protons vary over a wide range (6−104). Low protection factors (<25) may indicate fluctuations in structure resulting in substantial solvent exposure. (3) Some hydrogen-bonded and buried protons show rapid exchange, and the protection factors are 25−400. This indicates kinetically labile hydrogen bonds and solvent exposure by structural fluctuations. On the other hand, many protons in this category exchange slower than the detection limit (<1.0 s-1) and are mainly observed in α helices and β sheets, or hydrophobic residues. Although a good correlation between NMR exchange measurements and X-ray structural properties was observed, discrepancies were also found for several residues, namely 80Gln, 82Thr, and 138Asn. The measured pH dependence revealed unusual behavior for 77Asn, possibly due to a tightly bound water molecule. Our data indicate that it is possible to use the exchange rates of rapidly exchanging protons as a probe for studying hydrogen bonding, solvent accessibility, or regional kinetic lability of protein structures in solution at physiological pH.
Adapting an English morphological analyzer for French (1988)

A word-based morphological analyzer and a dictionary for recognizing inflected forms of French words have been built by adapting the UDICI" system. We describe the adaptations, emphasizing mechanisms developed to handle French verbs. This work lays the groundwork for doing French derivational morphology and morphology for other languages.
ATP Synthesis During Low-Flow Ischemia (2000)

During low-flow ischemia simulating an acute myocardial infarction region, oxidative phosphorylation accounted for 90% of ATP synthesis. The CK velocity fell by 66%, and CK did not completely use available PCr to slow ATP depletion. G+I, by increasing glycolysis, slowed ATP depletion, maintained lower [P(i)], and maintained a higher free energy from ATP hydrolysis. This improved energetic profile resulted in better systolic and diastolic function during ischemia and reperfusion. These results support the clinical use of G+I in acute MI.
ChemInform Abstract: Mesoporous Aluminosilicate MCM‐41 as a Convenient Acid Catalyst for Friedel‐Crafts Alkylation of a Bulky Aromatic Compounds with Cinnamyl Alcohol. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synthesis and Evaluation of 1,1′‐Hydrocarbylenebis(indazol‐3‐ols) as Potential Antimalarial Drugs (2008)

Bis(indazol-3-ol) derivatives (5, 30-38) were prepared by alkylation of 3-alkoxyindazoles with alpha,omega-dibromides, followed by removal of the O-protecting groups. These compounds were subsequently evaluated as inhibitors of biocrystallization of ferriprotoporphyrin IX (heme) to hemozoin, a Plasmodium detoxification specific process. Most bis(5-nitroindazol-3-ols) were good inhibitors, however, a denitro analogue (38), the intermediate bis(3-alkoxyindazoles) (15-29) as well as bis(indazolin-3-ones) (39-42) were not active, showing the importance of the NO(2) and OH groups in the inhibition process.
Occult tumor cells in peritoneal lavage in pancreatic carcinoma patients. (2012)

e14556 Background: Pancreatic carcinoma is one of the most aggressive malignancies with a poor prognosis. Assessment of occult tumor cells could prevent aggressive surgery in patients with metastatic spread. The aim of this study was to investigate the prognostic significance of occult tumor cells in peritoneal lavage of patients with pancreatic carcinoma. Methods: This was a prospective study to assess the presence of occult tumor cells in peritoneal lavage of 96 pancreatic carcinoma patients at the time of surgery using real-time RT-PCR for carcinoembryonic antigen (CEA), epidermal growth factor receptor 1 (EGFR1) and human telomerase (hTERT). Gene expression of tested markers was correlated with clinical/pathological characteristics using Kruskal-Wallis Anova and Mann-Whitney tests. Kaplan-Meier methods and Gehan-Wilcoxon tests were used for overall survival analyses. Results: Overall, 65 of 96 (69.9%) pancreatic carcinoma patients died, the overall survival median was 10.3 months. A significant association between CEA expression in peritoneal lavage and the clinical stage was found (p&lt;0.03). In addition, patients with high grade tumors had significantly higher expression of EGFR in peritoneal lavage compared to patients with low grade tumors (p&lt;0.04). The patients with the presence of occult cancer cells detected in the peritoneal lavage using CEA and/or EGFR had significantly shorter overall survival (p&lt;0.001; HR=2.14 [95% CI: 1.30-3.55]) with overall survival median 6.8 months. Conclusions: These data demonstrate that the presence of occult tumor cells in peritoneal lavage is a negative prognostic factor in pancreatic carcinoma patients. Occult tumor cells detection using PCR based methods can identify patients with advanced disease for whom radical surgery is of no benefit. Prospective studies should confirm usefulness of this method for the selection of patients for radical surgery. Acknowledgements: Supported by grants IGA MZ NS 9937‑4, MPOTIP FR-TI1/525, IGA UP LF_2011_018 and CZ.1.05/2.1.00/01.0030.
Supplementary Tables S1-S2 from Prognostic Utility of Anti-EBV Antibody Testing for Defining NPC Risk among Individuals from High-Risk NPC Families (2023)

&lt;p&gt;Supplementary Tables S1-S2.&lt;/p&gt;
Poster (2014)

The continuously increasing number of smartphones and tablets allow the users to access Wireless LANs (WLANs) while undergoing different types of mobility, posing new challenges to wireless protocols. Current history-based WLAN protocols do not work well in mobile settings where wireless conditions change rapidly. Thus, today's WLANs need to be able to determine the type of the client's mobility and employ appropriate strategies in order to sustain high performance. While previous work tried to detect mobility using hints from sensors available in mobile devices, in this work, we demonstrate how different mobility modes can be distinguished by using physical layer information - Channel State Information (CSI) and Time-of-Flight (ToF) - available at commodity APs, with no modifications on the client side. Our testbed experiments show that our mobility classification algorithm achieves more than 92% accuracy in a variety of scenarios. In addition, we demonstrate how fine-grained mobility determination can be exploited to greatly improve performance of client roaming and MIMO beamforming.
Influence of Order within Nonpolar Monolayers on Hydrophobic Interactions (2017)

We report an experimental investigation of the influence of molecular-level order (crystallinity) within nonpolar monolayers on hydrophobic interactions. The measurements were performed using gold film-supported monolayers formed from alkanethiols (CH<sub>3</sub>(CH<sub>2</sub>)<sub>n</sub>SH, with n ranging from 3 to 17), which we confirmed by using polarization-modulation infrared reflection-adsorption spectroscopy to exhibit chain-length-dependent order (methylene peak moves from 2926 to 2919 cm<sup>-1</sup>, corresponding to a transition from liquid- to quasi-crystalline-like order) in the absence of substantial changes in chain density (constant methyl peak intensity). By using monolayer-covered surfaces immersed in either aqueous triethanolamine (TEA, 10 mM, pH 7.0) or pure methanol, we quantified hydrophobic and van der Waals contributions to adhesive interactions between identical pairs of surfaces (measured using an atomic force microscope) as a function of the length and order of the aliphatic chains within the monolayers. In particular, we measured pull-off forces arising from hydrophobic adhesion to increase in a nonlinear manner with chain length (abrupt increase between n = 5 and 6 from 2.1 ± 0.3 to 14.1 ± 0.7 nN) and to correlate closely with a transition from a liquid-like to crystalline-like monolayer phase. In contrast, adhesion in methanol increased gradually with chain length from 0.3 ± 0.1 to 3.2 ± 0.3 nN for n = 3 to 7 and then did not change further with an increase in chain length. These results lead to the hypothesis that order within nonpolar monolayers influences hydrophobic interactions. Additional support for this hypothesis was obtained from measurements reported in this paper using long-chain alkanethiols (ordered) and alkenethiols (disordered). The results are placed into the context of recent spectroscopic studies of hydrogen bonding of water at nonpolar monolayers. Overall, our study provides new insight into factors that influence hydrophobic interactions at nonpolar monolayers.
Bone-Anchored Hearing Device Surgery (2012)

Incomplete follow-up data can theoretically affect outcome data considerably. Therefore, outcome data should also be presented with life table and worst-case scenario. This would enhance the possibility to interpret and compare data.
X-ray observations of the Galactic center by SPARTAN 1 (1988)

The results of Spartan 1 X-ray observations of the region within 1.25 deg of the Galactic center are presented. Four strong, hard X-ray point sources were detected: A1742-294, 1E 1740.7-2942, IE 1743.1-2843, and a new source SP 1744.2-2959 about 0.5 deg southeast of A1742-294. The new source had an intensity about 20 percent of that of A1742-294 and was relatively hard, having spectral parameters close to those of the diffuse source and of the Galactic bulge source GX 3+1. The Galactic nucleus X-ray source appears to have been a factor of four fainter during the 1985 Spartan 1 observations than during the 1979 Einstein observations. Hard, diffuse X-ray emission centered near the Galactic center, about 1 deg in extent, aligned to within 20 deg of the Galactic equator, and having a maximum 2-10 keV brightness of 1.5 x 10 to the -6th ergs/sq cm/s/sr was detected, as were two weaker point sources about 0.1 deg northeast and southeast of the Galactic nucleus, embedded in the diffuse emission.
Facial expression recognition under a wide range of head poses (2015)

Most of the facial expression recognition methods assume frontal or near-frontal head poses and usually their accuracy strongly decreases when tested with non-frontal poses. Training a 2D pose-specific classifier for a large number of discrete poses can be time consuming due to the need of many samples per pose. On the other hand, 2D and 3D view-point independent approaches are usually not robust to very large head rotations. In this paper we transform the problem of facial expression recognition under large head rotations into a missing data classification problem. 3D data of the face are projected onto a head pose invariant 2D representation and in this projection the only difference between poses is due to self-occlusions with respect to the depth sensor's position. Once projected, the visible part of the face is split in overlapping patches which are input to independent local classifiers and a voting scheme gives the final output. Experimental results on common benchmarks show that our method can accurately recognize facial expressions in a much larger pan and tilt range than state-of-the-art approaches, obtaining comparable performance to the best existing systems working only in narrower ranges.
Synthesis and properties of two-dimensional nanostructures by direct intercalation of polymer melts in layered silicates (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and properties of two-dimensional nanostructures by direct intercalation of polymer melts in layered silicatesRichard A. Vaia, Hope Ishii, and Emmanuel P. GiannelisCite this: Chem. Mater. 1993, 5, 12, 1694–1696Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/cm00036a004https://doi.org/10.1021/cm00036a004research-articleACS PublicationsRequest reuse permissionsArticle Views2963Altmetric-Citations1041LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Compact semilumped elliptic‐function low‐pass filter using microstrip meander line (2007)

Abstract For the size reduction and sharp attenuation of the low‐pass filter in lower RF frequency range, a semilumped elliptic‐function low‐pass filter was proposed using microstrip meander line, chip capacitor, and radial stubs. To estimate more accurate inductance of microstrip meander line, it was modeled in an inhomogeneous dielectric environment, and then the calculated inductance was compared with the conventional case. To provide an additional attenuation pole in stop‐band, radial stubs were added to the proposed structure. The 3‐order low‐pass filter has a cutoff frequency of 1GHz and dimension of 14.6 × 16.3 mm 2 on the substrate with a relative dielectric constant of 3.38. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 1777–1779, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22545
Rational Design of Self‐Assembling Artificial Proteins Utilizing a Micelle‐Assisted Protein Labeling Technology (MAPLabTech): Testing the Scope** (2022)

Self-assembling artificial proteins (SAPs) have gained enormous interest in recent years due to their applications in different fields. Synthesis of well-defined monodisperse SAPs is accomplished predominantly through genetic methods. However, the last decade has witnessed the use of a few chemical technologies for this purpose. In particular, micelle-assisted protein labeling technology (MAPLabTech) has made huge progress in this area. The first generation MAPLabTech focused on site-specific labeling of the active-site residue of serine proteases to make SAPs. Further, this methodology was exploited for labeling of N-terminal residue of a globular protein to make functional SAPs. In this study, we describe the synthesis of novel SAPs by developing a chemical method for site-specific labeling of a surface-exposed cysteine residue of globular proteins. In addition, we disclose the synthesis of redox-sensitive SAPs and their systematic self-assembly and disassembly studies using size-exclusion chromatography. Altogether these studies further expand the scope of MAPLabTech in different fields such as vaccine design, targeted drug delivery, diagnostic imaging, biomaterials, and tissue engineering.
Ready-to-use nanopore platform for the detection of any DNA/RNA oligo at attomole range using an Osmium tagged complementary probe (2020)

ABSTRACT Nanopores can serve as single molecule sensors. We exploited the MinION, a portable nanopore device from Oxford Nanopore Technologies (ONT), and repurposed it to detect any DNA/RNA oligo (target) in a complex mixture by conducting voltage-driven ion-channel measurements. The detection and quantitation of the target is enabled by the use of a unique complementary probe. Using a validated labeling technology, probes are tagged with a bulky Osmium tag (Osmium tetroxide 2,2’-bipyridine), in a way that preserves strong hybridization between probe and target. Intact oligos traverse the MinION’s nanopore relatively quickly compared to the device’s acquisition rate, and exhibit count of events comparable to the baseline. Counts are reported by a publicly available software, OsBp_detect . Due to the presence of the bulky Osmium tag, probes traverse more slowly, produce multiple counts over the baseline, and are even detected at single digit attomole (amole) range. In the presence of the target the probe is “silenced”. Silencing is attributed to a 1:1 double stranded (ds) complex that doesn’t fit and can’t traverse this nanopore. This ready-to-use platform can be tailored as a diagnostic test to meet the requirements for point-of-care cell-free tumor DNA (ctDNA) and microRNA (miRNA) detection and quantitation in body fluids.
Glucose Metabolism After Renal Transplantation (2013)

Glucose metabolism differs substantially between kidney transplant recipients and nontransplant controls. Because impaired insulin secretion appears to be the predominant pathophysiological feature after renal transplantation, early therapeutic interventions that preserve, maintain, or improve β-cell function are potentially beneficial in this population.
Characterisation of transcriptionally active and inactive chromatin domains in neurons (2000)

The tandemly organised ribosomal DNA (rDNA) repeats are transcribed by a dedicated RNA polymerase in a specialised nuclear compartment, the nucleolus. There appears to be an intimate link between the maintenance of nucleolar structure and the presence of heterochromatic chromatin domains. This is particularly evident in many large neurons, where a single nucleolus is present, which is separated from the remainder of the nucleus by a characteristic shell of heterochromatin. Using a combined fluorescence in situ hybridisation and immunocytochemistry approach, we have analysed the molecular composition of this highly organised neuronal chromatin, to investigate its functional significance. We find that clusters of inactive, methylated rDNA repeats are present inside large neuronal nucleoli, which are often attached to the shell of heterochromatic DNA. Surprisingly, the methylated DNA-binding protein MeCP2, which is abundantly present in the centromeric and perinucleolar heterochromatin, does not associate significantly with the methylated rDNA repeats, whereas histone H1 does overlap partially with these clusters. Histone H1 also defines other, centromere-associated chromatin subdomains, together with the mammalian Polycomb group factor Eed. These data indicate that neuronal, perinucleolar heterochromatin consists of several classes of inactive DNA, that are linked to a fraction of the inactive rDNA repeats. These distinct chromatin domains may serve to regulate RNA transcription and processing efficiently and to protect rDNA repeats against unwanted silencing and/or homologous recombination events.
Extracellular Replication ofListeria monocytogenesin the Murine Gall Bladder (2004)

The bacterium Listeria monocytogenes can cause a life-threatening systemic illness in humans. Despite decades of progress in animal models of listeriosis, much remains unknown about the processes of infection and colonization. Here, we report that L. monocytogenes can replicate in the murine gall bladder and provide evidence that its replication there is extracellular and intraluminal. In vivo bioluminescence imaging was employed to determine the location of the infection over time in live animals, revealing strong signals from the gall bladder over a period of several days, in diseased as well as asymptomatic animals. The data suggest that L. monocytogenes may be carried in the human gall bladder.
Issues in the architecture of a document archiver using optical disk technology (1985)

Article Free Access Share on Issues in the architecture of a document archiver using optical disk technology Author: S. Christodoulakis Computer Systems Research Institute, University of Toronto and Computer Research Institute of Crete Computer Systems Research Institute, University of Toronto and Computer Research Institute of CreteView Profile Authors Info & Claims SIGMOD '85: Proceedings of the 1985 ACM SIGMOD international conference on Management of dataMay 1985 Pages 34–50https://doi.org/10.1145/318898.318901Published:01 May 1985Publication History 9citation296DownloadsMetricsTotal Citations9Total Downloads296Last 12 Months6Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Aplicação de SPME (Solid Phase Micro-Extraction) na análise de águas potáveis de três localidades do estado de São Paulo (1998)

Made available in DSpace on 2014-12-02T16:25:38Z (GMT). No. of bitstreams: 1 WOS000077040600023.pdf: 270596 bytes, checksum: 2551e59bd782b69fc59b3cf36070c881 (MD5) Previous issue date: 1998
Three-dimensional cephalometric outcome predictability of virtual orthodontic-surgical planning in surgery-first approach (2022)

The presented 3DCA offers a valid aid in performing VOSP and analysing orthognathic surgery outcomes, especially in SF. Thanks to the cephalometric analysis, we found that surgery-first approach outcome unpredictability is mainly tied to the sagittal positioning of the maxilla and that the transverse symmetry is progressively less predictable in a craniocaudal direction.