gebhart/patrepeval huggingface dataset:
Invasive pulmonary aspergillosis in patients with solid tumours: risk factors and predictors of clinical outcomes (2018)

IPA should be considered in patients with solid tumours, particularly those with underlying lung disease. Key messages Invasive pulmonary aspergillosis should be considered in patients with solid tumours, particularly those with underlying lung disease, lung cancer and those who received chest radiotherapy. Most of the patients with invasive pulmonary aspergillosis and solid tumours presented with nonspecific symptoms and signs as well as nonspecific CT findings. Unlike patients with hematologic malignancies, fever and hemoptysis were not predominant symptoms and the classical halo sign and the air-crescent sign were not described. Independent risk factors for 12-week mortality included receiving steroids within 30 days of diagnosis and chest radiotherapy. In multivariate analysis, a positive fungal stain was associated with lower odds of a successful response to antifungal therapy, whereas voriconazole treatment was associated with higher odds.
High Oxygen Barrier Polyester from 3,3′-Bifuran-5,5′-dicarboxylic Acid (2023)

An exceptional oxygen barrier polyester prepared from a new biomass-derived monomer, 3,3'-bifuran-5,5'-dicarboxylic acid, is reported. When exposed to air, the furan-based polyester cross-links and gains O<sub>2</sub> permeability 2 orders of magnitude lower than initially, resulting in performance comparable to the best polymers in this class, such as ethylene-vinyl alcohol copolymers. The cross-links hinder the crystallization of amorphous samples, also rendering them insoluble. The process was observable via UV-vis measurements, which showed a gradual increase of absorbance between wavelengths of 320 and 520 nm in free-standing films. The structural trigger bringing about these changes appears subtle: the polyester containing 5,5'-disubstituted 3,3'-bifuran moieties cross-linked, whereas the polyester with 5,5'-disubstituted 2,2'-bifuran moieties was inert. The 3,3'-bifuran-based polyester is effectively a semicrystalline thermoplastic, which is slowly converted into a cross-linked material with intriguing material properties once sufficiently exposed to ambient air.
Welcome message from general chairs (2017)

Presents the introductory welcome message from the conference proceedings. May include the conference officers' congratulations to all involved with the conference event and publication of the proceedings record.
Data from Telaglenastat Plus Cabozantinib or Everolimus for Advanced or Metastatic Renal Cell Carcinoma: An Open-Label Phase I Trial (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Dual inhibition of glucose and glutamine metabolism results in synergistic anticancer effects in solid tumor models. Telaglenastat, an investigational, small-molecule, glutaminase inhibitor, exhibits modest single-agent activity in renal cell carcinoma (RCC) patients. This phase Ib trial evaluated telaglenastat plus cabozantinib or everolimus, agents known to impair glucose metabolism in patients with metastatic RCC (mRCC).&lt;/p&gt;Patients and Methods:&lt;p&gt;mRCC patients received escalating doses of telaglenastat [400–800 mg per os (p.o.) twice daily] in a 3 + 3 design, plus either everolimus (10 mg daily p.o.; TelaE) or cabozantinib (60 mg daily p.o.; TelaC). Tumor response (RECISTv1.1) was assessed every 8 weeks. Endpoints included safety (primary) and antitumor activity.&lt;/p&gt;Results:&lt;p&gt;Twenty-seven patients received TelaE, 13 received TelaC, with median 2 and 3 prior therapies, respectively. Treatment-related adverse events were mostly grades 1 to 2, most common including decreased appetite, anemia, elevated transaminases, and diarrhea with TelaE, and diarrhea, decreased appetite, elevated transaminases, and fatigue with TelaC. One dose-limiting toxicity occurred per cohort: grade 3 pruritic rash with TelaE and thrombocytopenia with TelaC. No maximum tolerated dose (MTD) was reached for either combination, leading to a recommended phase II dose of 800-mg telaglenastat twice daily with standard doses of E or C. TelaE disease control rate (DCR; response rate + stable disease) was 95.2% [20/21, including 1 partial response (PR)] among 21 patients with clear cell histology and 66.7% (2/3) for papillary. TelaC DCR was 100% (12/12) for both histologies [5/10 PRs as best response (3 confirmed) in clear cell].&lt;/p&gt;Conclusions:&lt;p&gt;TelaE and TelaC showed encouraging clinical activity and tolerability in heavily pretreated mRCC patients.&lt;/p&gt;&lt;/div&gt;
Edit, compile, debug: from hacking to distributed engineering (2002)

Specifying a system from different viewpoints, in heterogeneous design notations, and using a distributed team, introduces several challenges that test the state of the art in software engineering. One of these challenges is to check the consistency of such heterogeneous notations, and to deal with the problem of inconsistency throughout the lifecycle — including the management of inconsistency between notations at the same stages of the lifecycle, such as multiple UML models, and inconsistency between stages, such as the consistency of design and code.
Impact of Inertial Training on Muscle Strength and Quality of Life in Breast Cancer Survivors (2022)

The aim of the study was to evaluate the impact of inertial training on the muscle strength, on breast-cancer-related lymphedema, and on quality of life in breast cancer survivors. After a mastectomy, 24 women (age, 66.2 ± 10.6 years) were randomized to a training (n = 12) or control group (n = 12). The training group performed inertial training twice per week for 6 weeks with a training load of about 70% of the maximal force. Before and after training, we tested the maximum force of shoulder flexors, extensors, abductors, and adductors; body composition; breast-cancer-related lymphedema; and disabilities of the arm, shoulder, and hand. Inertial training significantly improved the strength in all tested muscles (from 32 to 68%; effect size (ES) from 0.89 to 1.85 in the impaired limb and from 31 to 64%; ES from 0.86 to 1.57 in the unimpaired limb). However, changes in the control group were not significant. Quality of life improved following treatment; the disabilities of the arm, shoulder, and hand score decreased significantly by 24.5% (ES from—0.29 to 1.38), p ≤ 0.05 in the training group and by 3.99% (ES from −0.49 to 1.14) in the control group p > 0.05. Breast-cancer-related lymphedema and body composition did not change significantly after the intervention in either group. We recommend inertial training for increasing muscle strength and improving quality of life in breast cancer survivors.
Beating Heart Catheter-Based Edge-to-Edge Mitral Valve Procedure in a Porcine Model (2004)

Edge-to-edge mitral valve approximation can be successfully and reliably achieved with a catheter-delivered clip without cardiopulmonary bypass, resulting in durable healing. The success of this device supports the development of a percutaneous catheter-based system for mitral valve repair.
Zora: a pilot virtual community in the pediatric dialysis unit. (2001)

We describe a five-month pilot project conducted in the dialysis unit at Boston's Children's Hospital. Pediatric patients with renal disease used the Zora therapeutic community program while undergoing hemodialysis. Zora is a 3D multi-user computer environment designed at the MIT Media Laboratory to help young people explore issues of identity, while engaging in a virtual community. Users build "virtual rooms" and populate them with objects and characters, program them with storytelling behaviors, and converse with other young people in real-time through a virtual character representing themselves. It was specifically designed to help young people explore issues of identity, while engaging in a participatory virtual community. This paper presents the experience and evaluates the feasibility and safety of using Zora in a hospital setting. It describes how Zora facilitated explorations of identity and mutual patient support and interaction. Finally it also presents design recommendations for future interventions of this kind. More generally, this paper explores the potential of technology specifically designed with therapeutic purposes to help patients cope with their illness.
A Voice From the Clinic: New Techniques for the Treatment of Recurrent Respiratory Papilloma (2000)

No AccessPerspectives on Voice and Voice DisordersArticle1 Dec 2000A Voice From the Clinic: New Techniques for the Treatment of Recurrent Respiratory Papilloma Robin A. Samlan, Paul W. Flint, and Celia Bassich-Zeren Robin A. Samlan The Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine Baltimore, MD Google Scholar , Paul W. Flint The Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine Baltimore, MD Google Scholar and Celia Bassich-Zeren Department of Communication Sciences and Disorders, Towson University Towson, MD Google Scholar https://doi.org/10.1044/vvd10.2.4 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In "A Voice From the Clinic: New Techniques for the Treatment of Recurrent Respiratory Papilloma." Perspectives on Voice and Voice Disorders, 10(2), pp. 4–5 References Abramson, A. L., Shikowitz, M. J., Mullooly, V. M ., Steinberg, B.Mv Amelia, C. A., & Rothstein, H. R. (1992). Clinical effects of photodynamic therapy on recurrent laryngeal papillomas.Arch Otolaryngology-Head Neck Surgery, 118, 25–9. Google Scholar Flint, P. W. (2000). Powered surgical instruments for laryngeal surgery.Otolaryngology Head-Neck Surgery. 222(2), 263–6. Google Scholar Pransky, S. M., Magit, A. M., Kearns, D. B., Kang, D. R., & Duncan, N. O. (1999). Intralesional cidofovir for recurrent respiratory papillomatosis in children.Archives of Otolaryngology-Head Neck Surgery, 125, 1143–8. Google Scholar Rosen, C A., Woodson, G. E., Thompson, J. W., Hengesteg, A. P., & Bradlow, H. L. (1998). Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis.Otolaryngology-Head Neck Surgery, 118(6), 810–5. Google Scholar Shikowitz, M. J., Abramson, A. L., Freeman, K., Steinberg, B. M., & Nouri, M. (1998). Efficacy of DHE photo-dynamic therapy for respiratory papillomatosis: Immediate and long-term results.Laryngoscope, 108, 962–967. Google Scholar Snoeck, R., Wieens, W., Desloovere, C, et al. (1998). Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(s)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine].Journal of Virology, 54, 219–25. Google Scholar Additional Resources FiguresReferencesRelatedDetails Volume 10Issue 2December 2000Pages: 4-5 Get Permissions Add to your Mendeley library History Published in issue: Dec 1, 2000 Metrics Topicsasha-topicsasha-sigsasha-article-typesleader-topicsCopyright & Permissions© 2000 American Speech-Language-Hearing AssociationPDF downloadLoading ...
Clotho: an Audio Captioning Dataset (2020)

Audio captioning is the novel task of general audio content description using free text. It is an intermodal translation task (not speech-to-text), where a system accepts as an input an audio signal and outputs the textual description (i.e. the caption) of that signal. In this paper we present Clotho, a dataset for audio captioning consisting of 4981 audio samples of 15 to 30 seconds duration and 24 905 captions of eight to 20 words length, and a baseline method to provide initial results. Clotho is built with focus on audio content and caption diversity, and the splits of the data are not hampering the training or evaluation of methods. All sounds are from the Freesound platform, and captions are crowdsourced using Amazon Mechanical Turk and annotators from English speaking countries. Unique words, named entities, and speech transcription are removed with post-processing. Clotho is freely available online <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> .
Effect of high‐pressure homogenisation on metabolic potential of Lacticaseibacillus paracasei 90: in vitro and in situ studies in fermented milk and semihard cheese (2023)

The influence of high‐pressure homogenisation (HPH) at 100 MPa on Lacticaseibacillus paracasei 90 (L90) was studied in vitro and in situ (fermented milk and cheese). Lysis and injury signs were observed in cells treated with HPH, which were linked to the release of intracellular enzymes and changes in the metabolic activity of L90. HPH treatment led to a higher lactic acid content and lower pH and pyruvic acid levels in fermented milk. The microbiological and peptide profiles of cheeses were modified by using cells or cell‐free extracts of L90. Finally, this study suggests that L90 could release bioactive peptides.
Fast-convolution implementation of linear equalization based multiantenna detection schemes (2014)

This contribution addresses the channel equalization for MIMO systems utilizing filter bank based multicarrier (FBMC) transmission. The proposed frequency-domain MIMO equalizer is integrated with the subcarrier processing of the fast-convolution filter bank (FC-FB) structure. The performance of the proposed scheme is evaluated for both the static user and the user with high mobility in highly frequency-selective propagation scenarios. It is shown that integrating the equalization functions with the FC-FB processing leads to a highly efficient overall implementation.
Multiversion reconciliation for mobile databases (1999)

As mobile computing devices become more and more popular mobile databases have started gaining popularity. An important feature of these database systems is their ability to allow optimistic replication of data by permitting disconnected mobile devices to perform local updates on replicated data. The fundamental problem in this approach is the reconciliation problem, i.e. the problem of serializing potentially conflicting updates performed by local transactions on disconnected clients on all copies of the database. We introduce a new algorithm that combines multiversion concurrency control schemes on a server with reconciliation of updates from disconnected clients. The scheme generalizes to multiversion systems, the single version optimistic method of reconciliation, in which client transactions are allowed to commit on the server iff data items in their read sets are not updated on the server after replication.
Enhanced Luminescence, Collective Heating, and Nanothermometry in an Ensemble System Composed of Lanthanide‐Doped Upconverting Nanoparticles and Gold Nanorods (2015)

A combined system of gold nanorods and NaGdF 4 :Er 3+ /Yb 3+ upconverting nanoparticles with double functionality, luminescence enhancement, and monitored heating is introduced. The paired nanostructures could become an excellent optical heater with thermal probe incorporated. To study their interaction, the longitudinal surface plasmon resonance of the gold nanorods is tuned to 980 nm, in resonance with the Yb 3+ absorption wavelength, so they can be simultaneously excited. Gold nanorods create a localized electromagnetic field that enhances the emission intensity from upconverting nanoparticles. This luminescence enhancement is shown to depend on the interparticle distance and excitation power and, in this system, reaches a maximum enhancement of 9 for the green emission of Er 3+ ions. At the same time, evidence of strong collective heating from the gold nanorods is demonstrated. The temperature can be controlled by changing the excitation power and measured in situ via the Er 3+ thermally sensitive luminescence. At high excitation powers, the heating can trigger a deformation of the gold nanorods, which limits the maximum temperature achievable in the system to 160 °C. Combining these nanostructures provides an all‐optical heating system with improved emission intensity that can monitor the temperature achieved.
Apparatus and method for measuring critical current properties of a coated conductor (2023)

The transverse critical-current uniformity in a superconducting tape was determined using a magnetic knife apparatus. A critical current I.sub.c distribution and transverse critical current density J.sub.c distribution in YBCO coated conductors was measured nondestructively with high resolution using a magnetic knife apparatus. The method utilizes the strong depression of J.sub.c in applied magnetic fields. A narrow region of low, including zero, magnetic field in a surrounding higher field is moved transversely across a sample of coated conductor. This reveals the critical current density distribution. A Fourier series inversion process was used to determine the transverse J.sub.c distribution in the sample.
High-resolution population-specific recombination rates and their effect on phasing and genotype imputation (2020)

Abstract Founder population size, demographic changes (eg. population bottlenecks or rapid expansion) can lead to variation in recombination rates across different populations. Previous research has shown that using population-specific reference panels has a significant effect on downstream population genomic analysis like haplotype phasing, genotype imputation and association, especially in the context of population isolates. Here, we developed a high-resolution recombination rate mapping at 10kb and 50kb scale using high-coverage (20-30x) whole-genome sequenced 55 family trios from Finland and compared it to recombination rates of non-Finnish Europeans (NFE). We tested the downstream effects of the population-specific recombination rates in statistical phasing and genotype imputation in Finns as compared to the same analyses performed by using the NFE-based recombination rates. We found that Finnish recombination rates have a moderately high correlation (Spearman’s ρ =0.67-0.79) with non-Finnish Europeans, although on average (across all autosomal chromosomes), Finnish rates (2.268±0.4209 cM/Mb) are 12-14% lower than NFE (2.641±0.5032 cM/Mb). Finnish recombination map was found to have no significant effect in haplotype phasing accuracy (switch error rates ~ 2%) and average imputation concordance rates (97-98% for common, 92-96% for low frequency and 78-90% for rare variants). Our results suggest that downstream population genomic analyses like haplotype phasing and genotype imputation mostly depend on population-specific contexts like appropriate reference panels and their sample size, but not on population-specific recombination maps or effective population sizes. Currently, available HapMap recombination maps seem robust for population-specific phasing and imputation pipelines, even in the context of relatively isolated populations like Finland.
The infrared spectra of matrix isolated thorium and uranium tetrachlorides. Change of shape with matrix gas (1988)

When thorium or uranium tetrachlorides are isolated in neon matrices, the spectra can be interpreted in terms of a Td molecule with a small site effect. Spectra obtained using sputtering techniques to generate ThCl4 in argon matrices agreed with those obtained previously using conventional vaporisation techniques. Detailed calculations of the i.r. spectra of isotopically enriched and natural abundance Th35/37Cl4 show that in krypton ThCl4 is not tetrahedral.
Elongated Focus Optoacoustic Microscopy with Matched Bessel Beam Illumination and Ultrabroadband Axicon Detection (2022)

Current optoacoustic (OA) microscopy configurations often have narrow focal ranges that limit their use for fast volumetric imaging applications. Herein, the focal range of OA microscopes is extended by matching the elongated optical illumination profile of a Bessel beam with the pencil beam acoustic sensitivity profile of a broadband axicon detector. An inverted OA microscope is developed with interchangeable optical illumination and acoustic detection units to assess the working distance and resolutions retained with several combinations of illumination and detection profiles. Matching Bessel illumination with axicon detection extends the depth of focus 17‐fold over traditional configurations. Imaging a tilted mouse ear with the matched Bessel−axicon configuration reveals vasculature over a working distance exceeding 4.2 mm with optical resolution, while affording a sixfold increase in imaging volume over the same scanning duration compared with configurations using standard Gaussian illumination, demonstrating this approach's promise for increasing applications for OA microscopy in preclinical research.
Small-time asymptotics of hypoelliptic heat kernels near the diagonal, nilpotentization and related results (2021)

We establish small-time asymptotic expansions for heat kernels of hypoelliptic Hörmander operators in a neighborhood of the diagonal, generalizing former results obtained in particular by Métivier and by Ben Arous. The coefficients of our expansions are identified in terms of the nilpotentization of the underlying sub-Riemannian structure. Our approach is purely analytic and relies in particular on local and global subelliptic estimates as well as on the local nature of small-time asymptotics of heat kernels. The fact that our expansions are valid not only along the diagonal but in an asymptotic neighborhood of the diagonal is the main novelty, useful in view of deriving Weyl laws for subelliptic Laplacians. Incidentally, we establish a number of other results on hypoelliptic heat kernels that are interesting in themselves, such as Kac’s principle of not feeling the boundary, asymptotic results for singular perturbations of hypoelliptic operators, global smoothing properties for selfadjoint heat semigroups.
Kinematics of the hind limb in trotting horses after induced lameness of the distal intertarsal and tarsometatarsal joints and intra-articular administration of anesthetic (2000)

Increased length of hind limb protraction and symmetry of tubera coxae vertical excursion are sensitive indicators of improvement in tarsal joint lameness. When evaluating changes in tarsal joint lameness, evaluating the horse from the side (to assess limb protraction) is as important as evaluating from the rear (to assess pelvic symmetry).
Modeling of Slot Waveguide Sensors Based on Polymeric Materials (2011)

Slot waveguides are very promising for optical sensing applications because of their peculiar spatial mode profile. In this paper we have carried out a detailed analysis of mode confinement properties in slot waveguides realized in very low refractive index materials. We show that the sensitivity of a slot waveguide is not directly related to the refractive index contrast of high and low materials forming the waveguide. Thus, a careful design of the structures allows the realization of high sensitivity devices even in very low refractive index materials (e.g., polymers) to be achieved. Advantages of low index dielectrics in terms of cost, functionalization and ease of fabrication are discussed while keeping both CMOS compatibility and integrable design schemes. Finally, applications of low index slot waveguides as substitute of bulky fiber capillary sensors or in ring resonator architectures are addressed. Theoretical results of this work are relevant to well established polymer technologies.