gebhart/patrepeval huggingface dataset:
Evolving to a "lighter" software process: a case study (2002)

Many new development processes that characterize themselves as lightweight or agile have become fashionable, e.g. Extreme Programming (XP) (Beck, 2000; Cockburn, 2000; Rising and Janoff, 2000). Each of these processes is focused on maximizing the effectiveness of a small team of developers while anticipating changes in the development environment. These processes are mainly focused on the coding phase of the process and require strict adherence to the techniques set forth (Beck, 1999). Since most of these processes have at least some aspects that might seem radical to a more traditional process, e.g. pair programming (Williams et al., 2000), an issue arises of how to integrate a lightweight process into an existing development/maintenance effort without stalling the effort for retraining in the new techniques? How do we evolve a traditional process to a lighter one? This paper describes the experiences of a development effort within an organization of the United States government as it tried to evolve to a lighter process. The project was subjected to both organizational and technical changes that required the project to be able to adapt rapidly to new development landscapes.
Crystallisation-driven self-assembly of poly(2-isopropyl-2-oxazoline)-block-poly(2-methyl-2-oxazoline) above the LCST (2015)

The solution behaviour in water of a polyoxazoline-type block copolymer, namely poly(2-isopropyl-2-oxazoline)-block-poly(2-methyl-2-oxazoline), denoted as P(iPrOx-b-MeOx), above the lower critical solution temperature (LCST) of the PiPrOx block was exploited to induce a temporary or permanent self-assembly. Spherical micelles were first obtained and could be disassembled in a reversible manner when kept for a short period of time (i.e. t < 90 min) above the LCST, and cooled down to room temperature. In contrast, annealing the copolymer solution for more than 90 min at 65 °C induced the crystallisation of the PiPrOx block, as evidenced by wide angle X-ray scattering (WAXS) experiments. This crystallisation-driven self-assembly phenomenon resulted in different morphologies, including spherical and distorted crystallised micelles and micron-size fibers, their relative proportion varies with the annealing time. Formation of micron-size range fiber-like structures might be explained by the re-organization of parent crystallised micelles. The crystal structure, as determined by WAXS, appeared to be identical to that of the PiPrOx homopolymer.
A Minimum 2‐Year Follow‐up After Selective Anteromedial or Posterolateral Bundle Anterior Cruciate Ligament Reconstruction (2008)

Selective AM or PL bundle reconstruction showed improved joint stability, joint position sense, and Lysholm scores postoperatively. This procedure can be a treatment option for patients whose ACL remnants are left in certain conditions.
A unified model of turbulent mass transfer under different interfacial conditions (2009)

A theoretical model for predicting the damping of the normal velocity fluctuation close to a contaminated air-water interface is proposed. In the present model, the flow field close to a contaminated interface is approximated by superposition of a free-surface flow at a clean interface and a surfactant-induced flow. It is shown that the present model can predict the normal velocity fluctuation quite well under a wide range of the Marangoni number representing a degree of surface contamination. Finally, the predicted interface-normal velocity fluctuation is used to evaluate the interfacial mass transfer.
Gene profiling and pathway analysis of neuroendocrine transdifferentiated prostate cancer cells (2008)

Despite some overlap, each NE transdifferentiation inducing treatment was associated with a changed expression of a unique set of genes, and such gene profiling may help to elucidate the molecular mechanisms involved in NE transdifferentiation of prostate cancer cells.
miR-30-5p Functions as a Tumor Suppressor and Novel Therapeutic Tool by Targeting the Oncogenic Wnt/β-Catenin/BCL9 Pathway (2014)

Abstract Wnt/β-catenin signaling underlies the pathogenesis of a broad range of human cancers, including the deadly plasma cell cancer multiple myeloma. In this study, we report that downregulation of the tumor suppressor microRNA miR-30-5p is a frequent pathogenetic event in multiple myeloma. Evidence was developed that miR-30-5p downregulation occurs as a result of interaction between multiple myeloma cells and bone marrow stromal cells, which in turn enhances expression of BCL9, a transcriptional coactivator of the Wnt signaling pathway known to promote multiple myeloma cell proliferation, survival, migration, drug resistance, and formation of multiple myeloma cancer stem cells. The potential for clinical translation of strategies to re-express miR-30-5p as a therapeutic approach was further encouraged by the capacity of miR-30c and miR-30 mix to reduce tumor burden and metastatic potential in vivo in three murine xenograft models of human multiple myeloma without adversely affecting associated bone disease. Together, our findings offer a preclinical rationale to explore miR-30-5p delivery as an effective therapeutic strategy to eradicate multiple myeloma cells in vivo. Cancer Res; 74(6); 1801–13. ©2014 AACR.
Effects of Age and Gender on the Pharmacodynamics of Omapatrilat in Healthy Volunteers (2001)

Omapatrilat is the most clinically advanced member of a new class of cardiovascular drugs, vasopeptidase inhibitors. Omapatrilat is a single molecule that simultaneously inhibits neutral endopeptidase and angiotensin-converting enzyme, thus preserving vasodilator peptides and inhibiting production of the vasoconstrictor angiotensin II. In healthy male volunteers, omapatrilat decreased blood pressure while being generally well tolerated, with no serious adverse events. This study was undertaken to determine the effect of age and gender on the pharmacodynamics of omapatrilat. Healthy male or female volunteers between the ages of 18 and 80 were given a single oral dose of omapatrilat 40 mg. Neither age nor gender affected the vasopeptidase inhibition by omapatrilat. There were no differences between subject groups in the effect of omapatrilat on supine systolic, diastolic, or mean arterial blood pressure. Based on this study of healthy subjects, it can be concluded that it is not necessary to adjust the initial dose of omapatrilat for the treatment of hypertension based solely on age or gender.
A 2G/3G Cellular Analog Baseband Based on a Filtering ADC (2012)

A current-driven low-pass filter embedded in a sigma-delta analog-to-digital converter is presented. The implementation of a class-B feedback digital-to-analog converter, together with in-band noise reduction and passive filtering, gives the possibility to handle challenging wireless communication scenarios with low power consumption. The architecture is a suitable candidate to implement the entire baseband analog section of a Global System for Mobile Communications-Universal Mobile Telecommunications System (GSM-UMTS) reconfigurable receiver.
Review on extraction, characterization, surface treatment and thermal degradation analysis of new cellulosic fibers as sustainable reinforcement in polymer composites (2022)

Nowadays, as environmental awareness is key issue among researchers, scientific community is looking for natural materials as they are biodegradable, low cost, eco-friendly and also safe for health. Researchers and academicians have found many natural fibers and studied their properties for their sustainable applications in various possible sectors, and studies are also going on. So, in that context several natural fiber like jute, sisal, banana, pineapple, flax, hemp, kenaf, bamboo, cornstalk waste, coir, etc. have been successfully utilized as a reinforcing material in polymer composites by replacing man made synthetic fiber. Apart from traditional natural fibers, scientific community is also looking for locally available natural fibers across the globe in different geographical locations for successful reinforcement in polymer matrix. This will not only decrease burden on traditional fibers and but also at the same time it would be helpful to enrich the rural economy. Natural fiber based composites can be used in different areas such as auto motive industry, construction industry, sports industry and food industry. This study is related with extraction, characterization, surface treatment thermal analysis and activation energy of different uncommon natural fibers available at different geographical locations worldwide. The purpose of this study is to provide a comprehensive knowledge on extraction techniques, treatment methodologies, and properties of these uncommon natural fibers so that these novel materials can be utilized efficiently as a reinforcing material in different polymer matrix. Discussions on traditional natural fibers like Bagasse, Wheat straw, Coir, Pineapple, Banana etc. have been compiled extensively in various review papers but compilation on these new uncommon natural fibers is rare. Thermal analysis along with activation energy evaluation is another aspect which has been given emphasis in discussion because this is also a very important examination to evaluate the thermal stability of these natural fibers.
Ecological Diversity: Measuring the Unmeasurable (2018)

Diversity is a concept central to ecology, and its measurement is essential for any study of ecosystem health. But summarizing this complex and multidimensional concept in a single measure is problematic. Dozens of mathematical indices have been proposed for this purpose, but these can provide contradictory results leading to misleading or incorrect conclusions about a community’s diversity. In this review, we summarize the key conceptual issues underlying the measurement of ecological diversity, survey the indices most commonly used in ecology, and discuss their relative suitability. We advocate for indices that: (i) satisfy key mathematical axioms; (ii) can be expressed as so-called effective numbers; (iii) can be extended to account for disparity between types; (iv) can be parameterized to obtain diversity profiles; and (v) for which an estimator (preferably unbiased) can be found so that the index is useful for practical applications.
Measurement Uncertainty in the Calibration of Low‐flow Ambient Air Samplers (2005)

Abstract This paper considers the quality of measurement for a new standard used to assess ambient airflow measurements. The quality is quantified through the uncertainty associated in the measurements of this device. While guidelines are available for these analyses, this case study presents a set of additional challenges since the flow rate measurements are based on a linear relationship between two functions where the variables making up these functions are measured with non‐negligible error. In order to estimate the parameters describing this linear relationship, it is necessary to account for the variability associated with these errors. Measurement error modeling approaches can be used to estimate the linear regression parameters and the associated uncertainties. Ordinary least squares procedures are simpler, but must be used with care since the estimates can be biased and the resulting uncertainties can be underestimated. Once estimates for the linear relationship are obtained, measurements from the device are used to calculate a predicted flow rate. Techniques are presented for estimating the uncertainty associated with this predicted flow rate. Copyright © 2005 John Wiley &amp; Sons, Ltd.
No allelic association of an exon 13 polymorphism of the Gsα gene to alcohol and/or drug dependence (1997)

Abstract The adenylyl cyclase signal transduction system, a ubiquitous second messenger system, has been identified as a potential marker for genetic risk of alcohol and drug dependence. Using the polymerase chain reaction (PCR) to amplify exon 13 of the Gsα gene, two alleles were distinguished by denaturing gradient gel electrophoresis. One allele, designed A, contained the previously published C in the codon for asparagine 371, while the second allele, designated A, contains a C‐T transition that conserves the asparagine residue at codon 371. The neutral polymorphism eliminates a Fok I restriction enzyme cleavage site, allowing use of restriction fragment length polymorphisms of PCR products to determine allelic frequency in 235 subjects with alcohol and/or drug dependence and in 85 control subjects. Since allele frequencies differ significantly by race, comparisons between affected individuals and controls were conducted separately for white and black groups. Within race, there were no significant differences in the frequency of the A allele among alcoholics, subjects dependent on cocaine or opioids, subjects dependent on these drugs and alcohol, and controls. We conclude that there is no association between alcohol and/or drug dependence and alleles of an exon 13 polymorphism of the Gsα gene in either black or white individuals.
Routine genotyping of human papillomavirus samples in Denmark (2003)

In order to examine a sensitive unbiased consensus PCR with routine sequencing for HPV typing, we analysed Danish male and female patients suspected of having an HPV infection. We used the well-characterised nested PCR setting with MY09/MY11 and GP5+/GP6+ primers, followed by routine cycle sequencing. Of 1283 clinical samples from female patients based on suspected HPV infection, we found 379 (29%) negatives and 894 (70%) positives. Samples containing >5000 HPV copies/ml were genotyped by sequencing. Of the 552 HPV genotyped samples from women >15 years of age, 398 were characterised as high-risk types and the remaining 154 as low-risk types. The most commonly found high-risk types were HPV-16, HPV-31, HPV-33, HPV-18, HPV-58, and HPV-52, and the most commonly found low-risk types were HPV-6, HPV-53 and HPV-11. In addition, we observed that other typing assays could not perform as sensitively or accurately as the nested PCR/cycle sequencing method used in this study. For instance, 87 out of 552 genotyped samples could not have been typed correctly in the Hybrid Capture II assay. Of these 87 samples, 46 (53%) were considered as high-risk types.
SARS-CoV-2 Neutralizing Antibodies Kinetics Postvaccination in Cancer Patients under Treatment with Immune Checkpoint Inhibition (2022)

Considering that COVID-19 could adversely affect cancer patients, several countries have prioritized this highly susceptible population for vaccination. Thus, rapidly generating evidence on the efficacy of SARS-CoV-2 vaccination in the subset of patients with cancer under active therapy is of paramount importance. From this perspective, we launched the present prospective observational study to comprehensively address the longitudinal dynamics of immunogenicity of both messenger RNA (mRNA) and viral vector-based vaccines in 85 patients treated with immune checkpoint inhibitors (ICIs) for a broad range of solid tumors. Despite the relatively poor humoral responses following the priming vaccine inoculum, the seroconversion rates significantly increased after the second dose. Waning vaccine-based immunity was observed over the following six months, yet the administration of a third booster dose remarkably optimized antibody responses. Larger cohort studies providing real-world data with regard to vaccines effectiveness and durability of their protection among cancer patients receiving immunotherapy are an increasing priority.
Role of Diffusion Weighted MRI in Maple Syrup Urine Disease: Rare Cause of Neonatal Metabolic Encephalopathy (2013)

The newborn presenting with neurological symptoms such as seizures or lethargy due to inborn error of metabolism is an important problem. Maple syrup urine disease (MSUD) is an inherited genetic disease, caused by a deficiency of the catalytic components of α-ketoaciddehydrogenase complex, which is responsible for the catabolism of branched-chain amino acids. The purpose of this case report is to show diffusion-weighted imaging (DWI) MRI findings of acute phase of classic form of MSUD in a newborn although this imaging findings are rare but very typical, known as “MSUD oedema”. DOI: http://dx.doi.org/10.3126/jnps.v33i3.8365 J. Nepal Paediatr. Soc. 2013;33(3):230-233
Biscyclooctatetraene and the phenylcyclooctatetraene anion disproportionation equilibriums (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiscyclooctatetraene and the phenylcyclooctatetraene anion disproportionation equilibriumsCheryl D. StevensonCheryl D. StevensonMore by Cheryl D. Stevenson and Jesus G. ConcepcionJesus G. ConcepcionMore by Jesus G. ConcepcionCite this: J. Am. Chem. Soc. 1973, 95, 17, 5692–5694Publication Date (Print):August 1, 1973Publication History Published online1 May 2002Published inissue 1 August 1973https://pubs.acs.org/doi/10.1021/ja00798a040https://doi.org/10.1021/ja00798a040research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Human Serum Promotes Osteogenic Differentiation of Human Dental Pulp Stem Cells In Vitro and In Vivo (2012)

Human dental pulp is a promising alternative source of stem cells for cell-based tissue engineering in regenerative medicine, for the easily recruitment with low invasivity for the patient and for the self-renewal and differentiation potential of cells. So far, in vitro culture of mesenchymal stem cells is usually based on supplementing culture and differentiation media with foetal calf serum (FCS). FCS is known to contain a great quantity of growth factors, and thus to promote cell attachment on plastic surface as well as expansion and differentiation. Nevertheless, FCS as an animal origin supplement may represent a potential means for disease transmission besides leading to a xenogenic immune response. Therefore, a significant interest is focused on investigating alternative supplements, in order to obtain a sufficient cell number for clinical application, avoiding the inconvenients of FCS use. In our study we have demonstrated that human serum (HS) is a suitable alternative to FCS, indeed its addition to culture medium induces a high hDPSCs proliferation rate and improves the in vitro osteogenic differentiation. Furthermore, hDPSCs-collagen constructs, pre-differentiated with HS-medium in vitro for 10 days, when implanted in immunocompromised rats, are able to restore critical size parietal bone defects. Therefore these data indicate that HS is a valid substitute for FCS to culture and differentiate in vitro hDPSCs in order to obtain a successful bone regeneration in vivo.
The Evolution of 4D Monitoring at the Valhall Field, from Permanent Cables to Retrievable Nodes (2018)

Summary The first large scale permanent reservoir monitoring system was installed at the Valhall field in 2003. Ocean bottom cables were trenched beneath the seabed, in order to provide frequent time-lapse images of the reservoir. Changing requirements for acquisition frequency and areal coverage have led to the utilization of retrievable ocean bottom nodes for the most recent surveys. An overlap in the transition from permanent to retrievable instruments provided an opportunity to make a direct comparison of the 4D signal recorded simultaneously by both cables and nodes. We compare the 4D quality of both systems using standard repeatability metrics, and demonstrate that ocean bottom nodes provide high quality time-lapse images that complement the historical 4D library of data from the permanent array.
Properties of ITO thin films deposited on amorphous and crystalline substrates with e-beam evaporation (2004)

Indium tin oxide (ITO) thin films were deposited using the e-beam evaporation method on amorphous and crystalline substrates under identical conditions. The properties of the films were investigated using optical transmittance, XRD and XPS techniques. It was found that the properties of the films depend strongly on the nature of the substrate surface. Analysis suggests that changes in chemical composition and microstructure of the ITO films deposited on crystalline and amorphous substrates are responsible for the differences in optical properties.
A laboratory guide to genomic sequencing : the direct sequencing of native uncloned DNA (1987)

I. Introduction.- A Safety Considerations.- B Introduction.- C The Principle of Genomic Sequencing.- II Theoretical Background.- A Basic Theoiy of Genomic Sequencing.- B Flow Diagram.- III Experimental.- 1 Isolation of Genomic DNA.- 2 Restriction Digest of Genomic DNA.- 3 Chemical Sequencing Reactions on Restricted DNA.- 4 Separation of Reaction Products on a Sequencing Gel.- 5 Electrotransfer to Nylon Membranes.- 6 Immobilization of DNA on a Nylon Membrane.- 7 Prehybridization and Hybridization of Immobilized DNA with Labeled Single-Stranded DNA Probes.- 8 Processing of the Hybridized Filters.- 9 Autoradiography and Photography.- 10 Cloning of DNA Probe in M13.- 11 Large-Scale Preparation of Cloned DNA in M13.- 12 Synthesis of Oligonucleotide Primers and Single-Stranded Labeled Probes.- 13 Purification of Labeled Single-Stranded Probes.- IV Trouble-Shooting Guide and Examples.- V Appendix.- A Suppliers of Special Items and Constructions of Commercially Unavailable Equipment.- B Determination of DNA Concentration.- VI Bibliography.
8 Determination of the Saponin Content of Foods (2001)

There is currently much interest in the nutritional properties of “phytochemicals” — plant materials present at relatively low levels in foods but with significant biological activity.Saponins are one such class of phytochemicals which are present in many fiber-rich foods, particularly legumes. Their presence is relevant to human nutrition because they have been shown to increase fecal excretion of bile acids in humanand animal studies.
Service users’ disclosure practices following discharge from hospital (2014)

People use a range of techniques to avoid the stigma associated with receiving treatment for mental health problems. Brian Keogh describes some common reactions and the strategies that nurses can use to help them work through these issues