gebhart/patrepeval huggingface dataset:
Broadband and high-efficiency conversion from guided waves to spoof surface plasmon polaritons (2013)

The conversion from spatial propagating waves to surface plasmon polaritons (SPPs) has been well studied, and shown to be very efficient by using gradient-index metasurfaces. However, feeding energies into and extracting signals from functional plasmonic devices or circuits through transmission lines require the efficient conversion between SPPs and guided waves, which has not been reported, to the best of our knowledge. In this paper, a smooth bridge between the conventional coplanar waveguide (CPW) with 50 Ω impedance and plasmonic waveguide (e.g., an ultrathin corrugated metallic strip) has been proposed in the microwave frequency, which converts the guided waves to spoof SPPs with high efficiency in broadband. A matching transition has been proposed and designed, which is constructed by gradient corrugations and flaring ground, to match both the momentum and impedance of CPW and the plasmonic waveguide. Simulated and measured results on the transmission coefficients and near-filed distributions show excellent transmission efficiency from CPW to a plasmonic waveguide to CPW in a wide frequency band. The high-efficiency and broadband conversion between SPPs and guided waves opens up a new avenue for advanced conventional plasmonic integrated functional devices and circuits.
Validation of a multi-layer Green's function code for ion beam transport (2008)

Abstract To meet the challenge of future deep space programs, an accurate and efficient engineering code for analyzing the shielding requirements against high-energy galactic heavy ion radiation is needed. In consequence, a new version of the HZETRN code capable of simulating high charge and energy (HZE) ions with either laboratory or space boundary conditions is currently under development. This code, GRNTRN, is based on a Green’s function approach to the solution of the one-dimensional Boltzmann transport equation and like its predecessor is deterministic in nature. The computational model consists of the lowest order asymptotic approximation followed by a Neumann series expansion with non-perturbative corrections. The physical description includes energy loss with straggling, nuclear attenuation, nuclear fragmentation with energy dispersion and down shift. Code validation in the laboratory environment is addressed by showing that GRNTRN accurately predicts energy loss spectra as measured by solid-state detectors in ion beam experiments with multi-layer targets. In order to verify and benchmark the code with space boundary conditions, measured particle fluxes are propagated through several thicknesses of shielding using both GRNTRN and the current version of HZETRN. The favorable agreement obtained indicates that GRNTRN accurately models the propagation of HZE ions in laboratory settings. It also compares very well with the extensively validated space environment HZETRN code and thus provides verification of the HZETRN propagator.
Multi-resolution source coding using entropy constrained dithered scalar quantization (2004)

In this paper, we build multiresolution source codes using entropy constrained dithered scalar quantizers. We demonstrate that for n-dimensional random vectors, dithering followed by uniform scalar quantization and then by entropy coding achieves performance close to the n-dimensional optimum for a multiresolution source code. Based on this result, we propose a practical code design algorithm and compare its performance with that of the set partitioning in hierarchical trees (SPIHT) algorithm on natural images.
Wound Repair By Laser Welding (1986)

In this study, we have developed a concept of wound closure by laser welding and studied the wound healing process. In the first set of experiments, six-millimeter long, full-thickness incisions were made in the skin on the back of hairless mice. Control wounds were closed with interrupted 5-0 prolene suture. The experimental wounds were approximated and closed by laser welding using a Nd:YAG (1.06 &mu;m) laser. Selected wounds were excised for histopathology, transmission electron microscopy, tensile strength determination and assay of type I collagen specific messenger-RNA. The laser welded wounds demonstrated rapid healing with good cosmetic results. The tensile strength was identical both for laser welded and sutured wounds at 7, 16, and 21 days. A significant increase of type I collagen specific mRNA was noted in both specimens at 4, 10 and 16 days, but a higher level was recorded in the sutured specimens at day 16 (2652 vs. 911 U/pg total RNA). We further initiated a comparative study to identify the laser which would be most suitable for skin welding. For this purpose argon, Nd:YAG (1.06 &mu;m and 1.32 &mu;m) and CO<sub>2</sub> lasers were used to weld skin. Wound healing, tensile strength and collagen analyses were performed. The results indicated that both argon and Nd:YAG (1.32 &mu;m) lasers achieved the most effective closure. These results suggest that laser welding provides an efficient method for closing skin wounds. The laser welding has clear advantages over conventional suturing techniques, being sterile, non-tactile, not requiring introduction of foreign materials into the wound, and providing improved cosmetic results.
A Cellular Taxonomy of the Adult Human Spinal Cord (2022)

Abstract The mammalian spinal cord functions as a community of glial and neuronal cell types to accomplish sensory processing, autonomic control, and movement; conversely, the dysfunction of these cell types following spinal cord injury or disease states can lead to chronic pain, paralysis, and death. While we have made great strides in understanding spinal cellular diversity in animal models, it is crucial to characterize human biology directly to uncover specialized features of basic function and to illuminate human pathology. Here, we present a cellular taxonomy of the adult human spinal cord using single nucleus RNA-sequencing with spatial transcriptomics and antibody validation. We observed 29 glial clusters, including rare cell types such as ependymal cells, and 35 neuronal clusters, which we found are organized principally by anatomical location. To demonstrate the potential of this resource for understanding human disease, we analyzed the transcriptome of spinal motoneurons that are prone to degeneration in amyotrophic lateral sclerosis (ALS) and other diseases. We found that, compared with all other spinal neurons, human motoneurons are defined by genes related to cell size, cytoskeletal structure, and ALS, thereby supporting a model of a specialized motoneuron molecular repertoire that underlies their selective vulnerability to disease. We include a publicly available browsable web resource with this work, in the hope that it will catalyze future discoveries about human spinal cord biology.
In vivo resistance towards anthracyclines, etoposide, and cis-diamminedichloroplatinum(II). (1982)

From a single wild-type strain of Ehrlich ascites tumor, sublines resistant to daunorubicin, etoposide, and cis-diamminedichloroplatinum(II) have been developed in vivo. Different levels of resistance were achieved after 4 to 8 months for anthracyclines (greater than 32-fold), cis-diamminedichloroplatinum(II) (4-fold), and etoposide (greater than 6-fold). Anthracycline resistance was associated with decreased nuclear steady-state concentration of anthracyclines, increased content of high-molecular-weight membrane glycoproteins, and glucose-dependent drug extrusion after metabolic blockade with sodium azide. A similar "pump" system which was apparently not drug specific was also documented in etoposide resistance. Resistance towards cis-diamminedichloroplatinum(II) was accompanied by decreased cis-diamminedichloroplatinum(II)-induced DNA damage in vitro when proteinase K-resistant interstrand cross-links were measured by alkaline elution. Parallel in vivo studies revealed cross-resistance of various degrees among a number of anthracycline analogs, complete cross-resistance among daunorubicin, doxorubicin, and 4'-(9-acridinylamino)methanesulfon-M-anisidine (amsacrine), and partial cross-resistance between daunorubicin and etoposide. However, cis-diamminedichloroplatinum(II) was curative in anthracycline- and etoposide-resistant cells, as daunorubicin and etoposide were curative in acquired resistance towards cis-diamminedichloroplatinum(II). cis-Diamminedichloroplatinum(II) resistance was also overcome by the derivative 1,2,diaminocyclohexylplatinum malonate. The Vinca alkaloid vindesine, although only marginally active in the control tumor, was highly active in cells selected for cis-diamminedichloroplatinum(II) resistance. These in vivo patterns of cross-resistance and collateral sensitivity may be related to observations in clinical chemotherapy.
Juxtacellular Neuronal Labelling, Physiological Characterization and Phenotypic Identification of Single Neurons In Vivo (2012)

Characterisation of the phenotype and physiological responsiveness of a neuron and identification of its innervation target(s) are important objectives for neuroscientists. This chapter describes the technique of juxtacellular neuronal labelling and presents procedures for the light and electron microscopic visualisation of labelled neurons and the identification of their neurochemical phenotypes and inputs. For those with little experience in extracellular neuronal recording, a detailed description of the required pieces of equipment and how they are configured is also provided.
Wet oxidation as a pretreatment method for wastewaters contaminated by bioresistant organics (1997)

The partial wet air oxidation of aqueous solutions of polyethylene glycol, a model organic pollutant typically found in wastewaters of polymer-manufacturing, has been investigated at temperatures from 383 K to 513 K and oxygen partial pressures from 2 MPa to 3 MPa. The progress of the reaction was investigated in terms of COD and TOC removal, while fragmentation of the original polymer to lower molecular weight compounds was followed by means of liquid chromatography. The impact of various heterogeneous and homogeneous catalysts on the kinetics and mechanisms of the reaction has also been studied. Conversion of the model compound through various oxidation intermediates to end-products, such as carboxylic acids and oligomers, could be easily achieved even under mild operating conditions, while further total oxidation proved to be difficult even under more severe conditions. Catalysts were found to be, in general, capable of increasing the rates of total uncatalysed oxidation. The implications for complete removal of bioresistant organic pollutants by partial wet oxidation followed by a biological treatment step are also discussed.
Single Units and Sensation: A Neuron Doctrine for Perceptual Psychology? (1972)

The problem discussed is the relationship between the firing of single neurons in sensory pathways and subjectively experienced sensations. The conclusions are formulated as the following five dogmas: To understand nervous function one needs to look at interactions at a cellular level, rather than either a more macroscopic or microscopic level, because behaviour depends upon the organized pattern of these intercellular interactions. The sensory system is organized to achieve as complete a representation of the sensory stimulus as possible with the minimum number of active neurons. Trigger features of sensory neurons are matched to redundant patterns of stimulation by experience as well as by developmental processes. Perception corresponds to the activity of a small selection from the very numerous high-level neurons, each of which corresponds to a pattern of external events of the order of complexity of the events symbolized by a word. High impulse frequency in such neurons corresponds to high certainty that the trigger feature is present. The development of the concepts leading up to these speculative dogmas, their experimental basis, and some of their limitations are discussed.
Frontal Polymerization in Solution (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTFrontal Polymerization in SolutionJohn A. Pojman, Ginger Curtis, and Victor M. IlyashenkoView Author Information Department of Chemistry and Biochemistry University of Southern Mississippi Hattiesburg, Mississippi 39406-5043 Cite this: J. Am. Chem. Soc. 1996, 118, 15, 3783–3784Publication Date (Web):April 17, 1996Publication History Received9 January 1996Published online17 April 1996Published inissue 1 January 1996https://doi.org/10.1021/ja9600688Copyright © 1996 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1649Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (83 KB) Get e-AlertsSUBJECTS:Amides,Monomers,Polymer solutions,Polymerization,Thermal polymerization Get e-Alerts
Myoblast‐mediated gene transfer for therapeutic angiogenesis and arteriogenesis (2003)

Therapeutic angiogenesis aims at generating new blood vessels by delivering growth factors such as VEGF and FGF. Clinical trials are underway in patients with peripheral vascular and coronary heart disease. However, increasing evidence indicates that the new vasculature needs to be stabilized to avoid deleterious effects such as edema and hemangioma formation. Moreover, a major challenge is to induce new vessels that persist following cessation of the angiogenic stimulus. Mature vessels may be generated by modulating timing and dosage of growth factor expression, or by combination of 'growth' factors with 'maturation' factors like PDGF-BB, angiopoietin-1 or TGF-beta. Myoblast-mediated gene transfer has unique characteristics that make it a useful tool for studying promising novel approaches to therapeutic angiogenesis. It affords robust and long-lasting expression, and can be considered as a relatively rapid form of 'adult transgenesis' in muscle. The combined insertion of different gene constructs into single myoblasts and their progeny allows the simultaneous expression of different 'growth' and 'maturation' factors within the same cell in vivo. The additional insertion of a reporter gene makes it possible to analyze the phenotype of the vessels surrounding the transgenic muscle fibers into which the myoblasts have fused. The effects of timing and duration of gene expression can be studied by using tetracycline-inducible constructs, and dosage effects by selecting subpopulations consistently expressing distinct levels of growth factors. Finally, the autologous cell-based approach using transduced myoblasts could be an alternative gene delivery system for therapeutic angiogenesis in patients, avoiding the toxicities seen with some viral vectors.
Mental Health Cortisol and Stress in Female Healthcare Providers (2020)

Background Stress is globally recognized as a risk factor impacting workers’ health and workplace safety. Women healthcare professionals are at risk for considerable stress given the demanding nature of their jobs and working conditions. This study assesses levels of stress among the female healthcare professionals according to measures of their cortisol levels, subjective stress, and quality of sleep. Participants and Methods Using a cross-sectional research design, data on stress was collected from 335 apparently healthy adult women healthcare professionals work in the United Arab Emirates. Eligible women were asked to provide morning and bedtime saliva samples for analysis of their cortisol levels. Perceived Stress Scale, Stress Symptoms Scale, Brief Coping Scale, and Pittsburgh Sleep Quality Index were used to assess perceived stress level, symptoms of stress, strategies for stress coping, and sleep quality, consecutively. Results Of 335 participants, 121 (36.15%) had impaired morning cortisol levels (below normal range of 0.094-1.551 µg/dL) and 48 (14.3%) had impaired bedtime cortisol levels (above 0.359 µg/dL). Around 57% of women reported moderate levels of perceived stress, with more frequent reporting of symptoms of stress including heart rate, back and/or neck pain. Poor sleep quality was reported by around 60% of study participants. No significant association were noted between cortisol and psychosocial measurements of stress nor sleep quality. However, having night shift and longer shift duration of more than 8 hours associated significantly with impaired morning and bedtime cortisol levels (P ≥ 0.05). impaired cortisol level was strongly dependent upon using adaptive coping strategies through active coping, acceptance and seeking emotional support (P ≥ 0.05).

Conclusion Evaluating cortisol levels and subjective stress could help to identify groups with impaired response to stress and elevated cortisol levels. Our findings suggest examining shift work pattern and stress coping strategies in female healthcare professionals to promote their health, productivity and maintain workplace safety.
Modified formalin and methanol fixation methods for molecular biological and morphological analyses (1997)

Several simplified fixation methods were examined to determine their suitability for both molecular biological analyses and morphological study. Fixation with 10% v/v formalin alone at 4 degrees C and containing 5 mmol/L ethylenediamine-N,N,N',N'-tetraacetic acid (EDTA) at room temperature preserved significantly more high-molecular-weight DNA than 10% v/v formalin fixation at room temperature. The morphological differences between tissues fixed using these modified formalin fixation methods and conventional 10% v/v formalin fixation were negligible. Of the dehydration fixatives tested, 100% methanol did not cause regional differences due to artificial tissue shrinkage and the morphology of sections prepared by methanol fixation was preserved consistently better than that of acetone- or ethanol-fixed sections. All three dehydration fixatives preserved relatively higher-molecular-weight DNA and RNA, compared with formalin. Cold formalin, formalin containing EDTA at room temperature and 100% methanol are recommended as standard and additional fixatives routine clinicopathological laboratory use.
CENTRAL NEUROGENIC NEUROPROTECTION: PROTECTION OF BRAIN FROM FOCAL ISCHEMIA BY CEREBELLAR STIMULATION (1997)

ABSTRACT Electrical stimulation of the cerebellar fastigial nucleus (FN) elevates regional cerebral blood flow (rCBF) independently of cerebral metabolism (rCGU) throughout brain. One hour of FN stimulation also reduces, by up to 50%, the volume of the focal ischemic infarction produced by occlusion of the middle cerebral artery in rat. Protected areas correspond to the ischemic penumbra. Neuroprotection, while reversible, persists for weeks after 1h of stimulation. It cannot be attributed to increasing rCBF and/or reducing rCGU to improve matching of flow and metabolism. Conditional stimulation of FN initiates long‐lived inhibition of expression of peri‐infarction depolarizing waves, possibly by altering potassium‐channel function and suppresses induction of inducible nitric oxide synthase (iNOS) and ICAM in cerebral microvessels. The brain contains intrinsic networks which may protect the brain from ischemic injury, possibly by producing widespread and longterm suppression of electrical excitability and/or and expression of proinflammatory molecules.
ADIPOSE-TISSUE DERIVED STEM CELLS IN MUSCULOSKELETAL REPAIR AND REGENERATION (2012)

Introduction Mesenchymal stem cells (MSC) are an attractive cell population for regeneration of mesenchymal tissue such as bone and cartilage. Various studies have demonstrated the repair capacity of MSCs and even their usefulness in treating critical size defects. Much of the work conducted on adult stem cells has focused on MSCs found within the bone marrow stroma. Adipose tissue, like bone marrow, is derived from the embryonic mesenchyme and contains a stroma that is easily isolated. The aim of the present study is to evaluate the differentiation capability of adipose-tissue derived stem cells (ASC) extracted from the infrapatellar fat pad. Materials and Methods Human infrapatellar fat pad tissue was obtained from patients undergoing total joint replacement for osteoarthritis with full ethical consent. A multipotent progenitor cell population was derived after collagenase digestion from the adipose tissue. The ASCs were induced to differentiate towards adipogenic, chondrogenic, and osteogenic lineages for 21 days both in normoxic and hypoxic cell culture conditions. The differentiation and multilineage potential was assessed according to cell morphology and in vitro detection of tissue-specific differentiation molecules. Results After 3 weeks in culture the staining for oil-red-o, alcian bue, and alizarin-red confirmed the differentiation capability of ASC9s to adipogenic, chondrogenic, and osteogenic lineages, respectively. The hypoxic cell culture condition was found to support the ASCs9 chondrogenic differentiation capability and subsequently enhanced the proteoglycan release from the cells. Fluorescence-activated cell sorting (FACS) confirmed the presence of stromal precursor cell marker STRO-1 in the ASC population. Discussion Subcutaneous adipose tissue is particularly attractive reservoir for progenitor cells because it is easily accessible, rather abundant, and self-replenishing. The results of this study demonstrate that ASCs can be derived from infrapatellar fat pad and that they have potential for musculoskeletal tissue repair and regeneration. Further studies are underway to evaluate how to adopt a biomaterial to deliver these cells into the defect area to facilitate the healing response.
Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on Vinyl acetate, Human Health Part (2008)

Adopted by the SCHER during the 26th plenary of 17 November 2008, 8p.
Einführung (1994)

Am 23. Februar 1987 wurde die Erde von Milliarden und Abermilliarden extragalaktischer Botschafter durchquert. Nur einige wenige von ihnen machten auf unserem felsigen Planeten Halt; die überwältigende Mehrheit setzte ihren Flug durch den Weltraum unbeeindruckt fort.