gebhart/patrepeval huggingface dataset:
Functional additive models for optimizing individualized treatment rules (2021)

A novel functional additive model is proposed, which is uniquely modified and constrained to model nonlinear interactions between a treatment indicator and a potentially large number of functional and/or scalar pretreatment covariates. The primary motivation for this approach is to optimize individualized treatment rules based on data from a randomized clinical trial. We generalize functional additive regression models by incorporating treatment-specific components into additive effect components. A structural constraint is imposed on the treatment-specific components in order to provide a class of additive models with main effects and interaction effects that are orthogonal to each other. If primary interest is in the interaction between treatment and the covariates, as is generally the case when optimizing individualized treatment rules, we can thereby circumvent the need to estimate the main effects of the covariates, obviating the need to specify their form and thus avoiding the issue of model misspecification. The methods are illustrated with data from a depression clinical trial with electroencephalogram functional data as patients' pretreatment covariates.
Wave-front measurement errors from restricted concentric subdomains (2001)

In interferometry and optical testing, system wave-front measurements that are analyzed on a restricted subdomain of the full pupil can include predictable systematic errors. In nearly all cases, the measured rms wave-front error and the magnitudes of the individual aberration polynomial coefficients underestimate the wave-front error magnitudes present in the full-pupil domain. We present an analytic method to determine the relationships between the coefficients of aberration polynomials defined on the full-pupil domain and those defined on a restricted concentric subdomain. In this way, systematic wave-front measurement errors introduced by subregion selection are investigated. Using vector and matrix representations for the wave-front aberration coefficients, we generalize the method to the study of arbitrary input wave fronts and subdomain sizes. While wave-front measurements on a restricted subdomain are insufficient for predicting the wave front of the full-pupil domain, studying the relationship between known full-pupil wave fronts and subdomain wave fronts allows us to set subdomain size limits for arbitrary measurement fidelity.
Novel therapeutic strategies in the treatment of triple-negative breast cancer (2017)

Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer that is defined by negative estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status. Treating patients with TNBC remains clinically challenging, as patients are not candidates for endocrine or HER2-directed therapy. As a result, chemotherapy with traditional agents such as anthracyclines and taxanes remains the only available option with moderate success. Recent discoveries have revealed that TNBC is a heterogeneous disease at the clinical, histological and molecular levels. The use of biomarkers to identify distinct subsets of TNBC that derive the greatest benefit from presently approved as well as novel therapeutics has become the main focus of current research. The aim of this review is to explore the clinical and biological complexity of TNBC as well as identify novel therapeutic options that target the various molecular subsets of TNBC.
Altered White Matter Connectivity Within and Between Networks in Antipsychotic-Naive First-Episode Schizophrenia (2017)

Analyzing the schizophrenia connectome can identify illness-related alterations in connectivity across the brain. An important question that remains unanswered is whether connectivity alterations are already evident at the onset of illness, before treatment with antipsychotic medication and possible influences of neuroprogressive or secondary alterations related to chronic illness duration. In the present study, diffusion tensor imaging and deterministic fiber tractography were performed with 137 antipsychotic-naive first-episode schizophrenia patients and 113 matched healthy controls. Using graph theoretic analysis, groups were compared in global and regional measurements and modularity of white matter connectivity. Compared with controls, the patients showed significantly decreased total connection strength. Furthermore, patients demonstrated significantly decreased connections within and between brain modules. Several local brain regions within association cortex exhibited reduced nodal centralities and abnormal participant coefficient or intra-module degree, some of which were correlated with illness duration and overall functional disability. In never-treated schizophrenia patients, networks showed a less effective organizational pattern of white matter pathways. White matter disconnectivity occurred not only within but also between multiple modules, shedding light on the deficits of anatomical network organization early in the course of schizophrenia.
Need for pharmaceutical care during chemotherapy for prevention of side effects: examples of blood sugar monitoring in dexamethasone treatment (2012)

Purpose: Patients who receive chemotherapy for colorectal cancer with the prophylactic dexamethasone (DEX) for antiemesis may experience an abnormal elevation in their casual blood glucose levels. The purpose of this study was to determine the frequency of such a DEX-induced elevation in patients with metastatic colorectal cancer, and to emphasize the importance of pharmaceutical care in improving the quality of life of patients. Methods: We retrospectively analyzed data from 50 patients who had received chemotherapy with or without DEX. Results: Of the 30 patients who received DEX, 8 exhibited abnormally high blood glucose levels (>200 mg/dl on more than 2 occasions); 3 of these patients also had diabetes mellitus. None of the 20 patients who did not receive DEX exhibited a remarkable elevation in the blood glucose levels. Conclusions: We confirm that patients receiving concomitant administration of DEX with chemotherapy may exhibit elevated blood glucose levels. Because an increase in the blood glucose levels may produce symptoms indicative of diabetes such as fatigue, appropriate pharmaceutical care for early detection of the abnormal elevation in the blood glucose levels may be important in preventing complications in such patients.
Remediating Ni-phytotoxicity of contaminated Quarry muck soil using limestone and hydrous iron oxide (2000)

Remediation of excessive soil metals in situ is receiving new attention because the alternative, soil removal and replacement, is very expensive, requires disposal of the removed soil and may achieve no better environmental remediation than the in situ treatments. A factorial pot experiment was conducted with two muck soils contaminated by a Ni refinery; we tested the effectiveness of making the soil calcareous and addition of freshly precipitated hydous ferric oxide (HFO) in reducing soil Ni phytotoxicity to the Ni-sensitive crops, oat and redbeet, and a Ni-resistant crop, wheat. Fertilized but otherwise untreated soil caused significant Ni phytotoxicity to oats and redbeet, but not to wheat, on both soils. Adding limestone reduced the concentration of Ni in shoots of all species and alleviated the symptoms specific to Ni phytotoxicity in oat (banded chlorosis). The addition of HFO was more effective in reducing shoot Ni concentration in the redbeets than in crops from the Poaceae family. Both amendments induced phosphorus and/or manganese deficiency depending on the crop tested. The experiment indicates that some combination of limestone and Fe oxides can readily remediate Ni phytotoxicity of the tested soils, but that Mn and P fertilizers would be needed to achieve practical in situ remediation of Ni phytotoxicity of Quarry muck (Terric Mesisol). Key words: Nickel, soil, plant, phytotoxicity, remediation
The B-Value: A Tool for Monitoring Data (1988)

This paper considers the problem of monitoring slowly accruing data from a nonsequentially designed experiment. We describe the use of the B-value, which is a transformed Z-value, for the calculation of conditional power. In data monitoring, interim Z-values do not allow simple projections to the end of the study. Moreover, because of their popular association with P-values, Z-values are often misinterpreted. If observed trends are viewed as the realization of a Brownian motion process, the B-value and its decomposition allow simple extrapolations to the end of the study under a variety of hypotheses. Applications are presented to one- and two-sample Z-tests, the two-sample Wilcoxon rank sum test, and the log-rank test.
ChemInform Abstract: Chemoselective Deprotection of Aryl tert‐Butyldimethylsilyl Ethers Promoted by Phosphates. (2012)

Abstract Tbs functions at the aromatic moiety are deprotected selectively under conditions A).
Continuous speech recognition using syllables (1997)

The vast majority of work in continuous speech recognition uses phoneme-like units as the basic recognition component. The work presented here investigates the practicability of syllable-like units as the building blocks for recognition. A phonetically annotated telephony database is analysed at the syllable level, and a set of syllable-based HMMs are built. Refinements including the introduction of syllable-level bigram probabilities, wordand syllable-level insertion penalties, and the investigation of different model topologies are found to improve recogniser performance. It is found that the syllablebased recogniser gives recognition accuracies of over 60%, which compares with 35% as the baseline accuracy for monophone recognition. It is envisaged that practical applications of syllable recognition could be in a hybrid system, where the most common syllable HMMs would be used in conjunction with whole-word and phoneme models.
<title>Dependence of excimer laser beam properties on laser gas composition</title> (1993)

Several new applications of excimer lasers in industry and medicine have increased the requirements for control of excimer laser beam parameters. Some applications require precise control of spatial uniformity, pulse-to-pulse amplitude variations and temporal profiles. The spatial and temporal characteristics of excimer laser beams are affected by small changes in laser gas composition. The role of gas composition, as well as methods for controlling gas composition, are discussed in relation to critical beam parameters.
Neuropathology of paediatric chronic intestinal pseudo-obstruction and related animal models (2001)

Chronic intestinal pseudo-obstruction (CIP) in paediatric patients is due to heterogeneous aetiologies that include primary disorders of the enteric nervous system. These conditions are poorly delineated by contemporary diagnostic approaches, in part because the complex nature of the enteric nervous system may shelter significant physiological defects behind subtle or quantitative anatomical changes. Until recently, relatively few experimental animal models existed for paediatric CIP. However, the availability of rodent models, particularly novel mutants created in the last few years by genetic manipulations, has brought unprecedented opportunities to investigate molecular, cellular, physiological, and histological details of enteric neuropathology. Information gleaned from studies of these animals is likely to change diagnostic and therapeutic approaches to paediatric CIP and related conditions.
A framework for MLS interoperability (2002)

Distributed object oriented computing (DOC) is a new computing paradigm that promotes component based development, location independence, scalability, software reuse, etc. Users of multilevel security (MLS) technology want to take advantage of these new technologies However, the process of incorporating new technologies into MLS products is slower than the analogous process for non secure commercial products because MLS products must go through rigorous evaluation/certification procedures. We propose an architectural framework that speeds up the process of introducing new technologies to MLS users. We examine the drawbacks of traditional MLS approaches and take a fresh look at the requirements of MLS users. We then introduce security critical components that can enable MLS solutions and an MLS architectural framework that can accommodate not only legacy systems but also new technologies including DOC, without jeopardizing system security. Our framework separates security critical components/functions from the rest of the system because these components must go through rigorous evaluation/certification processes. This approach enables the secure use of new technologies for MLS users.
131I radioimmunotherapy and fractionated external beam radiotherapy: comparative effectiveness in a human tumor xenograft. (1999)

The relative effectiveness per unit dose of radiation therapy delivered by 131I-labeled A33 monoclonal antibodies was approximately one third of that produced by fractionated external beam radiotherapy, when measured by tumor regrowth delay.
Synthesis of high-molecular-weight poly(phenylene sulfide) by oxidative polymerization via poly(sulfonium cation) from methyl phenyl sulfoxide (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of high-molecular-weight poly(phenylene sulfide) by oxidative polymerization via poly(sulfonium cation) from methyl phenyl sulfoxideEishun Tsuchida, Eiichi Shouji, and Kimihisa YamamotoCite this: Macromolecules 1993, 26, 26, 7144–7148Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://doi.org/10.1021/ma00078a005RIGHTS & PERMISSIONSArticle Views855Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (663 KB) Get e-Alerts Get e-Alerts
Assessing Sedation with Regional Anesthesia: Inter-Rater Agreement on a Modified Wilson Sedation Scale (2002)

We evaluated the interrater reliability of the Wilson scale for measuring sedation during regional anesthesia. Paired anesthesia care providers' ratings of patient sedation indicated very good interrater reliability in both the original scale and a modified version. The modified Wilson scale provides a quick noninvasive means of monitoring sedation during regional anesthesia.
Solution Combustion Synthesis of Hafnium-Doped Indium Oxide Thin Films for Transparent Conductors (2022)

Indium oxide (In<sub>2</sub>O<sub>3</sub>)-based transparent conducting oxides (TCOs) have been widely used and studied for a variety of applications, such as optoelectronic devices. However, some of the more promising dopants (zirconium, hafnium, and tantalum) for this oxide have not received much attention, as studies have mainly focused on tin and zinc, and even fewer have been explored by solution processes. This work focuses on developing solution-combustion-processed hafnium (Hf)-doped In<sub>2</sub>O<sub>3</sub> thin films and evaluating different annealing parameters on TCO's properties using a low environmental impact solvent. Optimized TCOs were achieved for 0.5 M% Hf-doped In<sub>2</sub>O<sub>3</sub> when produced at 400 °C, showing high transparency in the visible range of the spectrum, a bulk resistivity of 5.73 × 10<sup>-2</sup> Ω.cm, a mobility of 6.65 cm<sup>2</sup>/V.s, and a carrier concentration of 1.72 × 10<sup>19</sup> cm<sup>-3</sup>. Then, these results were improved by using rapid thermal annealing (RTA) for 10 min at 600 °C, reaching a bulk resistivity of 3.95 × 10 <sup>-3</sup> Ω.cm, a mobility of 21 cm<sup>2</sup>/V.s, and a carrier concentration of 7.98 × 10<sup>19</sup> cm<sup>-3</sup>, in air. The present work brings solution-based TCOs a step closer to low-cost optoelectronic applications.
Sleep and Circadian Rhythms in Mammalian Torpor (2004)

Sleep and circadian rhythms are the primary determinants of arousal state, and torpor is the most extreme state change that occurs in mammals. The view that torpor is an evolutionary extension of sleep is supported by electrophysiological studies. However, comparisons of factors that influence the expression of sleep and torpor uncover significant differences. Deep sleep immediately following torpor suggests that torpor is functionally a period of sleep deprivation. Recent studies that employ post-torpor sleep deprivation, however, show that the post-torpor intense sleep is not homeostatically regulated, but might be a reflection of synaptic loss and replacement. The circadian system regulates sleep expression in euthermic mammals in such a way that would appear to preclude multiday bouts of torpor. Indeed, the circadian system is robust in animals that show shallow torpor, but its activity in hibernators is at least damped if not absent. There is good evidence from some species, however, that the circadian system plays important roles in the timing of bouts of torpor.
The Wave Function and Quantum Reality (2011)

We investigate the meaning of the wave function by analyzing the mass and charge density distributions of a quantum system. According to protective measurement, a charged quantum system has effective mass and charge density distributing in space, proportional to the square of the absolute value of its wave function. In a realistic interpretation, the wave function of a quantum system can be taken as a description of either a physical field or the ergodic motion of a particle. The essential difference between a field and the ergodic motion of a particle lies in the property of simultaneity; a field exists throughout space simultaneously, whereas the ergodic motion of a particle exists throughout space in a time‐divided way. If the wave function is a physical field, then the mass and charge density will be distributed in space simultaneously for a charged quantum system, and thus there will exist gravitational and electrostatic self‐interactions of its wave function. This not only violates the superposition principle of quantum mechanics but also contradicts experimental observations. Thus the wave function cannot be a description of a physical field but be a description of the ergodic motion of a particle. For the later there is only a localized particle with mass and charge at every instant, and thus there will not exist any self‐interaction for the wave function. It is further argued that the classical ergodic models, which assume continuous motion of particles, cannot be consistent with quantum mechanics. Based on the negative result, we suggest that the wave function is a description of the quantum motion of particles, which is random and discontinuous in nature. On this interpretation, the square of the absolute value of the wave function not only gives the probability of the particle being found in certain locations, but also gives the probability of the particle being there. The suggested new interpretation of the wave function provides a natural realistic alternative to the orthodox interpretation, and it also implies that the de Broglie‐Bohm theory and many‐worlds interpretation are wrong and the dynamical collapse theories are in the right direction by admitting wavefunction collapse.
A phase I and pharmacokinetic study of 1843U89, a noncompetitive inhibitor of thymidylate synthase, in patients with advanced solid malignancies. (2001)

This study was performed to assess the feasibility of administering 1843U89, a potent, noncompetitive inhibitor of thymidylate synthase that does not require polyglutamation for activity, as a 2-min i.v. infusion daily for 5 days every 3 weeks, to determine whether folic acid supplementation ameliorates the toxic effects of 1843U89 and permits further dose escalation, and to recommend doses of 1843U89 administered without and with folic acid for further clinical evaluations. The study also sought to characterize the pharmacokinetic behavior of 1843U89 and to seek preliminary evidence of anticancer activity. Patients with advanced solid malignancies were treated with escalating doses of 1843U89 as a 2-min i.v. infusion daily for 5 days every 3 weeks. Initially, patients were treated in the absence of high-dose folic acid until dose-limiting toxicity was consistently noted. Next, patients were treated with escalating doses of 1843U89 preceded by 1000 mg of folic acid administered p.o. 30 min before each of the 5 daily doses of 1843U89. Patients (32) received 101 total courses of 1843U89 at doses ranging from 1 to 6 mg/m(2)/day with and without folic acid. At the 2 mg/m(2)/day dose level without folic acid, 2 of 7 new patients experienced dose-limiting toxicity, principally neutropenia, mucositis, and malaise in 3 of 11 courses. 1843U89 doses were further increased with folic acid to 6 mg/m(2)/day, but repetitive treatment was not feasible at this dose level because of an unacceptable high incidence of severe neutropenia and mucositis. Other toxicities included thrombocytopenia, rash, and fever. In contrast, repetitive treatment at the 5 mg/m(2)/day dose level was feasible. The pharmacokinetics of 1843U89 were neither dose dependent nor affected by folic acid. On day 1, clearance, terminal half-life, and steady-state volume of distribution values averaged 47.1 +/- 21.7 ml/min/m(2), 7.72 +/- 4.09 h, and 16.7 +/- 8.8 liter/m(2)/h, respectively. The results of the study indicate that the administration of 1843U89 as a 2-min infusion daily for 5 days every 3 weeks without and with folic acid is feasible at 1843U89 doses as high as 2 and 5 mg/m(2)/day, respectively. Because folic acid pretreatment results in no diminution of the antitumor activity of 1843U89 in preclinical studies and ameliorates the toxic effects of 1843U89 in both preclinical models and cancer patients, the therapeutic index of 1843U89 may be enhanced by folic acid pretreatment and, therefore, the development of 1843U89 with folic acid is warranted. However, the question of whether to administer 1843U89 at a dose of 2 mg/m(2)/day with folic acid, which is associated with negligible toxicity, or at its highest feasible dose with folic acid, 5 mg/m(2)/day, should be addressed in appropriately designed trials.