gebhart/patrepeval huggingface dataset:
A Sationless Bikeshare Proof of Concept for College Campuses (2016)

Bikeshares promote healthy lifestyles and sustainability among commuters, casual riders, and tourists. However, the central pillar of modern systems, the bike station, cannot be easily integrated into a compact college campus. Fixed stations lack the flexibility to meet the needs of college students who make quick, short-distance trips. Additionally, the necessary cost of implementing and maintaining each station prohibits increasing the number of stations for user convenience. Therefore, the team developed a stationless bikeshare based on a smartlock permanently attached to bicycles in the system. The smartlock system design incorporates several innovative approaches to provide usability, security, and reliability that overcome the limitations of a station centered design. A focus group discussion allowed the team to receive feedback on the early lock, system, and website designs, identify improvements and craft a pleasant user experience. The team designed a unique, two-step lock system that is intuitive to operate while mitigating user error. To ensure security, user access is limited through near field ii communications (NFC) technology connected to a mechatronic release system. The said system relied on a NFC module and a servo working through an Arduino microcontroller coded in the Arduino IDE. To track rentals and maintain the system, each bike is fitted with an XBee module to communicate with a scalable ZigBee mesh network. The network allows for bidirectional, real-time communication with a Meteor.js web application, which enables user and administrator functions through an intuitive user interface available on mobile and desktop. The development of an independent smartlock to replace bike stations is essential to meet the needs of the modern college student. With the goal of creating a bikeshare that better serves college students, Team BIKES has laid the framework for a system that is affordable, easily adaptable, and implementable on any university expressing an interest in bringing a bikeshare to its campus.
Linear envelope model for multicharge state linac (2014)

The traditional linear envelope model is widely used in linac design and on-line tuning. However, for the simultaneous acceleration of multicharge states, the associated transfer matrix acts differently on each species with different charge to mass ratios and the traditional linear envelope model cannot be utilized. A direct way to handle multicharge state acceleration is by using multiparticle tracking, which can be high in model detail, but is typically lacking in computational efficiency to the extent where it is not suitable for on-line beam tuning of a linac. In this paper, a new approach of adapting a conventional linear envelope model to multicharge state acceleration is developed. The lattice of the proposed Facility for Rare Isotope Beams (FRIB) is used to test this technique in both the linac and the bend/folding segments of the machine. Results are benchmarked with the multiparticle tracking code IMPACT to both verify the accuracy of the model and clarify improvements in computational efficiency.
Conversion of Glycerol to 3-Hydroxypropanoic Acid by Genetically Engineered Bacillus subtilis (2017)

3-Hydroxypropanoic acid (3-HP) is an important biomass-derivable platform chemical that can be converted into a number of industrially relevant compounds. There have been several attempts to produce 3-HP from renewable sources in cell factories, focusing mainly on <i>Escherichia coli, Klebsiella pneumoniae</i>, and <i>Saccharomyces cerevisiae</i>. Despite the significant progress made in this field, commercially exploitable large-scale production of 3-HP in microbial strains has still not been achieved. In this study, we investigated the potential of <i>Bacillus subtilis</i> as a microbial platform for bioconversion of glycerol into 3-HP. Our recombinant <i>B. subtilis</i> strains overexpress the two-step heterologous pathway containing glycerol dehydratase and aldehyde dehydrogenase from <i>K. pneumoniae</i>. Genetic engineering, driven by <i>in silico</i> optimization, and optimization of cultivation conditions resulted in a 3-HP titer of 10 g/L, in a standard batch cultivation. Our findings provide the first report of successful introduction of the biosynthetic pathway for conversion of glycerol into 3-HP in <i>B. subtilis</i>. With this relatively high titer in batch, and the robustness of <i>B. subtilis</i> in high density fermentation conditions, we expect that our production strains may constitute a solid basis for commercial production of 3-HP.
Jane 2: Open Source Phrase-based and Hierarchical Statistical Machine Translation (2012)

We present Jane 2, an open source toolkit supporting both the phrase-based and the hierarchical phrase-based paradigm for statistical machine translation. It is implemented in C++ and provides efficient decoding algorithms and data structures. This work focuses on the description of its phrase-based functionality. In addition to the standard pipeline, including phrase extraction and parameter optimization, Jane 2 contains several state-of-the-art extensions and tools. Forced alignment phrase training can considerably reduce rule table size while learning the translation scores in a more principled manner. Word class language models can be used to integrate longer context with a reduced vocabulary size. Rule table interpolation is applicable for different tasks, e.g. domain adaptation. The decoder distinguishes between lexical and coverage pruning and applies reordering constraints for efficiency.
Range flow from stereo-temporal matching: application to skinning (2002)

Recently the 3D-MATIC Research Laboratory has developed techniques for the generation of 25 3D models per second of captured data. Our aim is to use these series of 3D models to study deformations of the human body. However since the 3D models have different topologies, they cannot be used directly for analyses of non-rigid motions. Therefore the generation of range flows is a prerequisite to further studies. Since we have acquired a lot of experience in correlating pixels in stereo pairs of images, we have naturally investigated the use of similar techniques to track pixels associated to range data between successive images. We present a method that allows the generation of range flows using stereo and temporal matching. We then demonstrate the efficiency of our techniques by applying the generated range flows to a study of the deformation of human skin around joints in order to perform the skinning of the region of interest.
Sending Your Government a Message: E-Mail Communications between Citizens and Government (2000)

From the Publisher:
In 1995, RAND published a report exploring the feasibility and societal implications of providing universal access to electronic mail within the United States (Robert H. Anderson et al., Universal Access to E-Mail: Feasibility and Societal Implications, MR-650-MF). Among the nine policy conclusions and recommendations in that report were these:
Supplementary Table 4C from Mitochondrially Targeted p53 Has Tumor Suppressor Activities <i>In vivo</i> (2023)

Supplementary Table 4C from Mitochondrially Targeted p53 Has Tumor Suppressor Activities &lt;i&gt;In vivo&lt;/i&gt;
Is There Currently an Established Role for the Use of Predictive or Prognostic Molecular Markers in the Management of Colorectal Cancer? A Point/Counterpoint (2012)

The term "personalized oncology" means different things to the oncologist than to the patient. But fundamentally, the phrase creates the expectation that decisions can be informed by the unique features of the patient and patient's cancer. Much like determining antibiotic sensitivities in urinary tract infections, the oncologist is expected to choose the right treatment(s), for each individual patient. Numerous methods can be used to "personalize" management decisions, although truly useful biomarkers continue to escape our grasp. Positron Emission Tomography in patients with GI stromal tumors or genotyping of c-kit in chronic myelogenous leukemia cells can guide the use of imatinib, these scenarios represent a minority of patients. The promise of individualized therapy, however, has led to the commercialization of numerous assays to probe patient's genetic make-up and that of the tumor. Breast cancer management has benefitted from the analysis of gene recurrence scores. More recently the analysis of germline or tumor-associated mutations in non-small cell lung cancer and melanoma has led to clinically meaningful molecular subsets of these diseases, guiding the successful targeting of such cancers with small-molecule inhibitors. Despite the high incidence of colorectal cancer and our relatively long-standing grasp of the molecular pathways in colorectal carcinogenesis, the management of these patients remains mostly empiric and movement toward "personalization" has been slow and incremental. Now, however, molecular imaging and commercial assays for genetic makeup of tumor specimens has put the oncologist and oncologic surgeon in the crossfire with patients and families who believe the era of "personalization" is here.
Catheter‐based treatment of the subclavian and innominate arteries (2008)

Catheter-based revascularization with stents for symptomatic S/IA lesions is safe and effective with excellent patency rates and sustained symptom resolution in the majority (>80%) of patients over 3 years of follow-up. Percutaneous primary stent therapy is the preferred method of revascularization in patients with suitable anatomy.
The effects of substrate coupling on triggering uniformity and ESD failure threshold of fully silicided NMOS transistors (2003)

We present a multi-finger turn-on model incorporating substrate coupling effects in multi-finger NMOS transistors during ESD events. It is demonstrated that the substrate coupling enables uniform triggering in a multi-finger structure. In addition, we show that fully silicided transistors can be used successfully as an ESD protection device without any design/process options if the effective epi thickness is larger than 1.5 /spl mu/m or bulk wafer is used.
Scale-up fermentation of Escherichia coli for the production of recombinant endoglucanase from Clostridium thermocellum (2021)

Endoglucanase (EC 3.2.1.4) catalysing the hydrolysis of β-1.4-glycosidic linkage of cellulose molecules is an enzyme of tremendous industrial importance. The present study describes a response surface methodology based predicted model to deduce a set of fermentation conditions for optimum growth and activity of recombinant endoglucanase in E. coli BL21 (DE3). Numerous significant parameters including fermentation media composition, temperature (Celsius), pH and agitation rate (rpm) were analysed systemically by employing central composite design. This effort reports highly efficient recombinant endoglucanase overproduction (6.9 gl<sup>-1</sup> of biomass) with 30% expression by E. coli in modified M9NG media incubated at 37 °C and pH 7 agitated at 200 rpm. Addition of 3 mM glucose and 24 mM glycerol in the M9NG media has shown positive effect on the enzyme yield and activity. The CMCase activity experimentally estimated was found to be 1185 U/mg with the optimized parameters. The outcomes of both the responses by the predicted quadratic model were found in consensus with the obtained values. Our results well depicted the favourable conditions to further scale-up the volumetric yield of other relevant recombinant enzymes and proteins.
Theoretical and experimental investigation of the equations of state and phase stabilities of MgS and CaS (1996)

The equations of state and phase stabilities of MgS and CaS are investigated via non-empirical theoretical calculations using three different electron-gas models: the self-consistent ion breathing (SCIB), the variationally induced breathing (VIB) and the potential-induced breathing (PIB) models. We apply these models on an equal footing using Kohn - Sham ionic densities and identical interaction density functionals. The calculated equations of state are compared to the compression curves of MgS at pressures up to 54 GPa and of CaS at pressures up to 52 GPa. The accuracies of the three electron-gas models in reproducing the equations of state of both compounds are generally comparable to those previously achieved for the binary oxide and halide systems. We also investigate the phase stabilities of MgS and CaS in CsCl (B2), wurtzite (B4) and zincblende (B3) structures. Our calculations accurately determine the B1 - B2 phase transition for CaS. In the case of MgS, the transition pressure is much higher than that of the current experimental measurement ranges. In addition, the models predict that the B4 phases of MgS and CaS can be stabilized under moderate tensions. This result is consistent with experimental observation of epitaxially stabilized MgS wurtzite films.
Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease (2015)

Development of therapeutic strategies to prevent Alzheimer's Disease (AD) is of great importance. We show that mild inhibition of mitochondrial complex I with small molecule CP2 reduces levels of amyloid beta and phospho-Tau and averts cognitive decline in three animal models of familial AD. Low-mass molecular dynamics simulations and biochemical studies confirmed that CP2 competes with flavin mononucleotide for binding to the redox center of complex I leading to elevated AMP/ATP ratio and activation of AMP-activated protein kinase in neurons and mouse brain without inducing oxidative damage or inflammation. Furthermore, modulation of complex I activity augmented mitochondrial bioenergetics increasing coupling efficiency of respiratory chain and neuronal resistance to stress. Concomitant reduction of glycogen synthase kinase 3β activity and restoration of axonal trafficking resulted in elevated levels of neurotrophic factors and synaptic proteins in adult AD mice. Our results suggest metabolic reprogramming induced by modulation of mitochondrial complex I activity represents promising therapeutic strategy for AD.
Managing Pulmonary Toxicities Associated with Immunotherapy: A Case Discussion (2019)

Immunotherapy has changed the field of oncology around the world with the approval of immune checkpoint inhibitors for a number of tumor types over the last 5 years. However, immune-mediated adverse events can be challenging and difficult to treat, with one of the most dire consequences being immune-mediated pneumonitis. KEY POINTS: Rapid intervention and aggressive management for grade 3 or greater pneumonitisSlow taper of steroids and also recommend pneumocystis carinii pneumonia prophylaxisMonitor carefully for a pneumonitis flare with steroid taper, which can occur in the absence of resuming anti-programmed cell death protein 1 (PD-1) [1], and do not resume anti-PD-1 therapy until completely off steroids and no clinical or radiologic evidence of recurrenceConsider observation without anti-PD-1 resumption-in this case, durable response was maintained even without resuming anti-PD-1 therapy.
Prognostic impact of hypercoagulability and impaired fibrinolysis in acute myocardial infarction (2023)

Gyeongsang National University Hospital (G-NUH) Registry, NCT04650529.
A fast-response, highly sensitive and selective fluorescent probe for the ratiometric imaging of hydrogen peroxide with a 100 nm red-shifted emission (2014)

Recently, growing attention has been paid to the accurate determination of hydrogen peroxide (H2O2) for elucidating its detailed biological function in physiology and pathology. A fluorescence method with the help of a fluorescent probe is the preferred technique for in situ visualization of biologically important species in vivo, even in single living cells. In the present manuscript, we developed a simple, fast response and highly selective fluorescent probe (1) with a receptor of the boronate moiety for the ratiometric imaging of H2O2 in living cells. Probe 1 could quantifiably detect H2O2 in the range of 18–540 μM by a ratiometric fluorescence spectroscopy method with a detection limit of 4 μM. Importantly, probe 1 exhibited 81 nm red-shifted absorption spectra accompanied by the color changes from colorless to yellow, and 100 nm red-shifted emission spectra upon addition of H2O2. Thus, 1 can serve as a “naked-eye” probe for H2O2. Preliminary bioimaging application and low cytotoxicity investigations further demonstrated that the proposed probe would be of great benefit to biomedical researchers for investigating the detailed biological function of H2O2 in biological systems.
Patterns of appearance and risk of misdiagnosis of intrahepatic cholangiocarcinoma in cirrhosis at contrast enhanced ultrasound (2013)

CEUS misdiagnosed as HCC a significantly higher number of ICC lesions in cirrhotic patients than CT and MRI. However, some CEUS contrast features can help suspect ICC, especially in some cases with inconclusive CT or MRI.
Shallow Bulk Acoustic Wave Devices (2005)

A brief overview of shallow bulk acoustic wave generation, propagation, and properties is presented. It is shown how the effect is manifested in doubly rotated crystal plates, and how certain features of device performance may be inferred from pre-existing calculations for bulk wave plates.
Understanding Fatigue in Progressive Supranuclear Palsy: Prevalence and Associated Factors (2021)

Abstract Background : Fatigue is a common and disabling non-motor symptom (NMS) of Parkinson’s disease (PD); however, it has been poorly understood in patients with progressive supranuclear palsy (PSP). We investigated the association between fatigue, clinical features, and other NMS in patients with probable PSP. Methods : In 72 probable PSP patients, fatigue was investigated using the PD fatigue scale (PFS). Further, all patients were evaluated using the PSP rating scale (PSPRS), Beck Depression Inventory (BDI), Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), PD Sleep Scale (PDSS), NMS scale (NMSS), PD Questionnaire-39 summary index (PDQ-39 SI), and Scale for Outcomes in PD-Autonomic (SCOPA-AUT). Results : The prevalence of fatigue was 38.9% (28/72) in patients with PSP. Logistic regression analysis showed that depression (BDI) was the factor associated with fatigue. We divided the patients into primary (fatigue without depression, n =16), secondary (fatigue with depression, n = 12), and non-fatigue groups. There were no differences in age, sex, disease duration, and PSPRS, PDSS, MMSE, and FAB scores among the three groups. The primary fatigue group had higher scores in PDQ-39 SI compared to the non-fatigue group. The secondary fatigue group showed higher scores in NMSS, PDQ-39 SI, and SCOPA-AUT compared to the non-fatigue group. PFS was positively correlated with NMSS and PDQ-39 SI and SCOPA-AUT. Conclusions : Fatigue is common in patients with PSP and is associated with the NMS and the quality of life in these patients. The present study provides meaningful insight into fatigue in patients with PSP.
Minimum-time/energy output-transitions in linear systems (2004)

This article addresses the optimal (minimum-time/energy) trajectory design for rapid output transitions, i.e. changing the output from one value to another, in linear systems. Furthermore, the output is required to be maintained constant (e.g. without vibration) outside the transition time interval. The output-transition problem is posed as a linear quadratic minimum-time (LQMT) optimal control problem, which avoids bang-bang controllers that result from solving the traditional time-optimal problem. Additionally, the LQMT approach allows the time-optimal requirement to be traded off with the energy requirement by selecting appropriated weighting factors. Current methods transform this LQMT output-transition problem into a state-transition problem by constraining the initial and final state of the output-transition interval. However, the choice of the initial and final states can be ad hoc and the resulting control law may not be optimal. In contrast, the proposed approach directly solves the LQMT output-transition problem by optimally choosing the initial and final states to minimize the output-transition cost. The novelty of the proposed approach is that inputs are not applied just during the output-transition time interval; rather, inputs are also applied before the beginning of and after the end of the output-transition time interval (these inputs are called pre- and post-actuation). The method is illustrated using a flexible structure model, and simulation results show substantial reduction in output-transition cost when compared with the cost of standard state-transition-based approaches, which do not use pre-and post-actuation.
Mechanism of action of antimicrobial peptide P5 truncations against Pseudomonas aeruginosa and Staphylococcus aureus (2019)

Rates of microbial drug resistance are increasing worldwide; therefore, antimicrobial peptides (AMPs) are considered promising alternative therapeutic agents to antibiotics. AMPs are essential components of the innate immune system and exhibit broad-spectrum antimicrobial activity. P5 is a Cecropin A-Magainin 2 hybrid analog peptide with antimicrobial activity against Gram-negative and Gram-positive bacteria. In the present study, truncated peptides were designed to reduction length, retainment their antimicrobial activity and low toxicity at high concentrations compared with that of the parent peptide P5. The truncated peptides P5-CT1 and P5-NT1 exhibited antibacterial activities against both Gram-negative and Gram-positive bacteria. In contrast, P5-CT2, P5-CT3, P5-NT2, and P5-NT3 showed higher antibacterial activities against gram-positive bacteria compared to Gram-negative bacteria at low concentration of peptides. The truncated peptides showed lower hemolytic activity and toxic effects against mammalian cells compared with those of the parent peptide P5. The levels of several truncated peptides were maintained in the presence of physiological concentrations of salts, indicating their high stability. The results of flow cytometry, propidium iodide uptake, n-phenyl-1-naphthylamine uptake, and 3,3'-dipropylthiadicarbocyanine iodide assays showed that these truncated peptides killed microbial cells by increasing membrane permeability, thereby causing membrane damage. The results suggested that truncated peptides of P5 have good potential for use as novel antimicrobial agents.
ChemInform Abstract: The Synergistic Inhibition Effect of Octylmercaptopropionate and 8‐ Quinolinol on the Corrosion of Iron in an Aerated 0.5 M Na2SO4 Solution. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.