gebhart/patrepeval huggingface dataset:
Real-Time Prediction of Large-Scale Ship Model Vertical Acceleration Based on Recurrent Neural Network (2020)

In marine environments, ships are bound to be disturbed by several external factors, which can cause stochastic fluctuations and strong nonlinearity in the ship motion. Predicting ship motion is pivotal to ensuring ship safety and providing early warning of risks. This report proposes a real-time ship vertical acceleration prediction algorithm based on the long short-term memory (LSTM) and gated recurrent units (GRU) models of a recurrent neural network. The vertical acceleration time history data at the bow, middle, and stern of a large-scale ship model were obtained by performing a self-propulsion test at sea, and the original data were pre-processed by resampling and normalisation via Python. The prediction results revealed that the proposed algorithm could accurately predict the acceleration time history data of the large-scale ship model, and the root mean square error between the predicted and real values was no greater than 0.1. The optimised multivariate time series prediction program could reduce the calculation time by approximately 55% compared to that of a univariate time series prediction program, and the run time of the GRU model was better than that of the LSTM model.
Cytologic Features and BRAF Mutation of Hyalinizing Trabecular Adenoma of the Thyroid - A Case Report with Review of the Literature - (2011)

A hyalinizing trabecular adenoma (HTA) is a rare benign thyroid tumor of follicular epithelial cell origin with a trabecular-alveolar growth pattern and marked intratrabecular hyalinization. The cytological and histological features of HTA are very similar to those of papillary and medullary carcinomas of the thyroid. Therefore, an accurate diagnosis of HTA is important to avoid unnecessary and potentially harmful management of patients. However, the results of BRAF gene mutation analysis shown by many studies are distinctly different between HTAs and papillary thyroid carcinomas. Herein, we describe a rare case of HTA of the thyroid in a 49-year-old female and consider its characteristic cytological features and BRAF gene mutation analysis results with a brief review of the literature.
Immunocytochemical localization of 4-ene steroid 5 alpha-reductase type 1 along the rat epididymis during postnatal development. (1994)

Dihydrotestosterone (DHT), the active androgen in many tissues, is synthesized from testosterone by the enzyme 4-ene steroid 5 alpha-reductase (5 alpha-reductase; EC 1.3.1.22). In the epididymis, the maturation and storage of spermatozoa are dependent on the presence of 5 alpha-reduced androgens. The regulation of epididymal 5 alpha-reductase is complex. To date, the regulation of this enzyme has been studied extensively at the level of enzymatic activity and more recently at the mRNA level. Regulation at the level of the protein, however, remains poorly understood. We have raised rabbit polyclonal antibodies to a 24-mer synthetic peptide whose sequence was determined from the predicted amino acid sequence for rat 5 alpha-reductase type 1 to immunolocalize the 5 alpha-reductase type 1 protein in the rat epididymis during postnatal development. Western blot analysis revealed a specific immunoreactive band of 26 kilodaltons in male rat liver, epididymis, and prostate; this apparent molecular size is identical to that obtained when the 5 alpha-reductase type 1 cDNA is expressed in mammalian cells. Furthermore, the relative protein levels, liver > epididymis > prostate, were consistent with the mRNA levels for type 1 rat 5 alpha-reductase. Perfusion-fixed paraffin-embedded epididymal tissue sections were used to immunolocalize type 1 5 alpha-reductase. In the adult rat epididymis, the most intense immunoperoxidase reaction was observed in a discrete lobule of the initial segment of the epididymis. A progressive decrease in staining intensity occurred distally along the tissue to the cauda epididymis. The staining reaction was specific to cytoplasmic elements of epithelial principal cells; no reaction was evident over nuclei. However, specifically in the initial segment, very intense staining was seen in the infranuclear region of the principal cells. In the proximal caput epididymidis, the staining was primarily confined to an oval region above the nuclei, whereas in the remaining epididymal regions, weak staining was seen throughout the cytoplasm. Thus, the intracellular localization of the 5 alpha-reductase type 1 protein changed as one moved down the epididymis. Finally, the pattern of immunolocalization of 5 alpha-reductase type 1 protein was different in the epididymis of rats of different postnatal ages. On day 7, no reactivity was noted; by day 28, a weak apical staining of principal cells was seen throughout the epididymis; by day 47, the adult pattern of staining had been established. Our results revealed that the expression and intracellular localization of the 5 alpha-reductase type 1 protein are both age dependent and epididymal segment specific.
LITMUS: multipurpose cloning vectors with a novel system for bidirectional in vitro transcription. (1995)

We describe the construction and uses of a set of four multipurpose cloning vectors: LITMUS 28, 29, 38 and 39. The vectors feature the high-copy pUC origin and an M13 origin for single-stranded DNA production as well as polylinker sites for most commercially available restriction enzymes that recognize nondegenerate hexanucleotide sites and yield 4-base sticky ends upon cleavage. Sites are arranged, without overlaps, to permit linker addition to blunt-ended fragments and unidirectional nested deletions and are within the lacZ alpha gene to facilitate blue-white screening. Finally, the polylinkers are flanked by a pair of opposing modified T7 promoters to allow in vitro transcription of either strand of a cloned insert with T7 RNA polymerase. Selective unidirectional transcription from one promoter is achieved by cleaving the other at an internal restriction site (AflII or SpeI). Both modified promoters are fully active under standard RNA probe synthesis conditions. In Southern blots of Dirofilaria immitis genomic DNA, an RNA probe prepared from LITMUS performed equivalently to the same RNA probe made from a wild-type promoter vector and a DNA probe prepared by random priming.
Electronic properties of graphene and boron-nitride based nanostructured materials (2011)

We study the electronic properties of graphene with periodic structural modifications using the local density approximation within the framework of the density functional theory. It is found that the double-layer graphene with nanotube arrays which connect the two sheets seamlessly is a direct-gap semiconductor. Also the single-layer graphene with periodic holes of 24-atomic-site vacancy is found to have a sizable direct fundamental gap as well. These graphene-based materials should be of high importance for nanoelectronics applications in the future. In addition, we study the electronic structure of the superlattice composed of graphene and boron-nitride layers which are stacked alternately. The material is found to be metallic even though each graphene layer is sandwiched by insulating BN layers and is very far from other graphene layers. The material may show interesting electronic properties being different from those of graphene.
Effect of Alcohol Drinking on Gene Expression of Hepatic O6‐Methylguanine DNA Methyltransferase in Chronic Liver Diseases (1996)

O6-methylguanine DNA methyltransferase (MGMT) is a repair protein that transfers methyl groups from O6-methylguanine to a cysteine acceptor in its own molecule, and restores DNA to its undamaged state. If left unrepaired, O6-methylguanine can pair with either a thymine or a cytosine, causing a C-G to T-A transition, which is considered to be one of the molecular mechanisms of both mutagenesis and carcinogenesis. The expression of MGMT mRNA in liver tissue was quantitatively assessed by the competitive reverse transcription-polymerase chain reaction method in patients with chronic liver diseases with or without alcohol drinking. MGMT mRNA expression was 1.4 +/- 0.9 pg/micrograms RNA in control livers. Its expression in chronic hepatitis was 3.8 +/- 0.7 in alcoholics and 2.7 +/- 0.8 in nonalcoholics, which were not statistically different. MGMT mRNA expression in liver cirrhosis was significantly low, compared with that in chronic hepatitis, and 0.8 +/- 0.3 in alcoholics and 0.5 +/- 0.1 in nonalcoholics, which also were not significantly different. The present study shows that MGMT mRNA was not decreased in patients with chronic liver diseases with alcohol drinking, compared with those without alcohol drinking.
Validation of the Standard Ship Motion Program, SMP: Ship Motion Transfer Function Prediction (1981)

A newly revised ship motion computer program has been developed for Navy-wide use, which incorporates the state-of-the-art prediction techniques. Validation of the calculated six-degree-of-freedom responses is essential to substantiate the accuracy of the program as well as to establish its value as a practical prediction tool. Measured and analytical transfer function data are compared for two Navy ships. Although overall good agreement is found between experiment and theory, future comparisons of a wider range of ship configurations will be required. The nonlinear characteristics of roll are also investigated in this report. Comparison of experiment and theory demonstrates improved prediction of roll at resonance. (Author)
Towards local rheology of emulsions under Couette flow using Dynamic Light Scattering (2002)

We present local velocity measurements in emulsions under shear using heterodyne Dynamic Light Scattering. Two emulsions are studied: a dilute system of volume fraction $ϕ=20$ % and a concentrated system with $ϕ=75$ %. Velocity profiles in both systems clearly show the presence of wall slip. We investigate the evolution of slip velocities as a function of shear stress and discuss the validity of the corrections for wall slip classically used in rheology. Focussing on the bulk flow, we show that the dilute system is Newtonian and that the concentrated emulsion is shear-thinning. In the latter case, the curvature of the velocity profiles is compatible with a shear-thinning exponent of 0.4 consistent with global rheological data. However, even if individual profiles can be accounted for by a power-law fluid (with or without a yield stress), we could not find a fixed set of parameters that would fit the whole range of applied shear rates. Our data thus raise the question of the definition of a global flow curve for such a concentrated system. These results show that local measurements are a crucial complement to standard rheological tools. They are discussed in light of recent works on soft glassy materials.
Reductions with Dialkylaluminum Hydrides (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReductions with Dialkylaluminum HydridesALFRED E. G. MILLER, JEAN W. BISS, and LOUIS H. SCHWARTZMANCite this: J. Org. Chem. 1959, 24, 5, 627–630Publication Date (Print):May 1, 1959Publication History Published online1 May 2002Published inissue 1 May 1959https://pubs.acs.org/doi/10.1021/jo01087a013https://doi.org/10.1021/jo01087a013research-articleACS PublicationsRequest reuse permissionsArticle Views2973Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Expression ofCgCDR1,CgCDR2, andCgERG11inCandida glabratabiofilms formed by bloodstream isolates (2008)

Many studies have shown that Candida biofilms are highly resistant to fluconazole. The mechanisms of acquired fluconazole resistance of Candida glabrata in non-biofilms have been elucidated, but the relevance of them relative to C. glabrata in biofilms are unknown. We examined by real-time PCR the expression of CgCDR1, CgCDR2, and CgERG11 of four bloodstream isolates of C. glabrata during the early (6 h), intermediate (15 h), and mature (48 h) phases of biofilm development. We found high levels of biofilm formation in vitro. At 6 and 15 h, the biofilms exhibited, in comparison to planktonic cells, approximately 1.5- and 3.3-fold upregulation of CgCDR1 and 0.5- and 3.1-fold upregulation of CgCDR2, respectively. However, at 48 h, neither gene was upregulated. In comparison, the expression of CgERG11 did not significantly increase during any of the three phases. Our results indicate a temporary increase in the expression of both CgCDR1 and CgCDR2 during the intermediate phase of C. glabrata biofilm development. In addition, the data collected at 48 h suggest that CgCDR1, CgCDR2, and CgERG11 may not play a role in the azole resistance of C. glabrata in mature biofilms.
1H NMR analysis of R-75-1 substance. (1981)

Compound R-75-1 is a very potent rifamycin derivative prepared from rifamycin SV at the Sichuan Institute of Antibiotics Industry, China in 1975. This compound showed a strong (see graphs in book) activity against Myobacterium tuberculosis and Gram-positive organisms. Here we describe the assignment of the 1H NMR spectrum of this novel compound.
Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein (2012)

Coronaviruses are enveloped positive-stranded RNA viruses that replicate in the cytoplasm. To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with the host cell membrane. The spike glycoprotein (S) mediates virus entry and is a primary determinant of cell tropism and pathogenesis. It is classified as a class I fusion protein, and is responsible for binding to the receptor on the host cell as well as mediating the fusion of host and viral membranes-A process driven by major conformational changes of the S protein. This review discusses coronavirus entry mechanisms focusing on the different triggers used by coronaviruses to initiate the conformational change of the S protein: receptor binding, low pH exposure and proteolytic activation. We also highlight commonalities between coronavirus S proteins and other class I viral fusion proteins, as well as distinctive features that confer distinct tropism, pathogenicity and host interspecies transmission characteristics to coronaviruses.
Other Issues in Statistics II (2018)

This chapter focuses on two important concepts: subgroup analysis and meta-analysis. Subgroup analysis is especially concerned about variability and how treatment effects can differ due to specific characteristics of the population. Important issues, however, arise when planning for subgroup analysis, such as dealing with false positives and methods for dealing with multiple statistical comparisons. The chapter also points out that the analysis of data from subgroups of patients with certain baseline characteristics is typically insufficient to change general clinical practice. The second section of this chapter focuses on meta-analysis, which is a method of pooling data from several studies in order to quantify the overall effect of an intervention or exposure, and thus potentially change clinical practice. This section discusses data search and synthesis, quantification of heterogeneity, choice of fixed or random model, as well as sensitivity analysis.
Thread-Level Parallelism &#x00026; Shared-Memory Pool Techniques for Authorization of Credit Card System (2008)

Nowadays, credit card is a famous trend used by millions of people around the world as a form of payment. This paper presented an architectural framework and prototype of credit card authorization system using thread-level parallelism and shared memory pool techniques in order to support dynamic tuning of the size of the thread pool at runtime. Normally, single threaded were chosen by software developer in current credit card authorization whereby authentication process takes longer time to respond and its limitation of handling huge number of simultaneous transactions at the same time. As a result, the performance of the authorization system was affected during peak hours. Through thread-level parallelism technique or usually known as multi-threading, each worker thread will be assigned with several child threads to perform online fraud validation concurrently, depending on numbers of cryptographic elements presented in transaction message while the work thread itself performed card restriction validation based on the card information stored in card's shared memory pool.
Handbook of Antibiotics (1993)

Handbook of antibiotics , Handbook of antibiotics , کتابخانه مرکزی دانشگاه علوم پزشکی تهران
Nonaqueous emulsion polymerization: A practical synthetic route for the production of molecularly imprinted nanospheres (2012)

Abstract Monodisperse, molecularly imprinted nanospheres were synthesized by nonaqueous (mini)emulsion polymerization using a standard monomer mixture of methacrylic acid and ethylene dimethacrylate containing the drug propranolol as a template. The preparation conditions (solvent, amount of surfactant, and amount of employed template) were extensively varied in order to assess their effect on the properties of the resulting polymer nanoparticles. The molecular recognition capability of the nanospheres was evaluated in batch rebinding experiments, and the effect of the nanosphere preparation conditions as well as of the reaction conditions was investigated. In this way, optimal preparation protocols for molecularly imprinted nanoparticles under nonaqueous conditions with the use of a nonionic emulsifier were identified, which lead to nanospheres with a diameter of around 100 nm having an enhanced capacity of specific template rebinding compared to both nonimprinted nanospheres and to particles obtained by emulsion polymerization in water. Best results were obtained with nanospheres prepared in N,N ‐dimethylformamide/ n ‐hexane with a high functional monomer to template ratio. The enantioselectivity of the rebinding process was also demonstrated. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013
Cytokine/anti‐cytokine therapy – novel treatments for asthma? (2011)

Asthma is a chronic inflammatory disease of the airways and there are no preventions or cures. Inflammatory cells through the secretion of cytokines and pro-inflammatory molecules are thought to play a critical role in pathogenesis. Type 2 CD4(+) lymphocytes (Th2 cells) and their cytokines predominate in mild to moderate allergic asthma, whereas severe steroid-resistant asthma has more of a mixed Th2/Th1 phenotype with a Th17 component. Other immune cells, particularly neutrophils, macrophages and dendritic cells, as well structural cells such as epithelial and airway smooth muscle cells also produce disease-associated cytokines in asthma. Increased levels of these immune cells and cytokines have been identified in clinical samples and their potential role in disease demonstrated in studies using mouse models of asthma. Clinical trials with inhibitors of cytokines such as interleukin (IL)-4, -5 and tumour necrosis factor-α have had success in some studies but not others. This may reflect the design of the clinical trials, including treatments regimes and the patient population included in these studies. IL-13, -9 and granulocyte-macrophage colony-stimulating factor are currently being evaluated in clinical trials or preclinically and the outcome of these studies is eagerly awaited. Roles for IL-25, -33, thymic stromal lymphopoietin, interferon-γ, IL-17 and -27 in the regulation of asthma are just emerging, identifying new ways to treat inflammation. Careful interpretation of results from mouse studies will inform the development and application of therapeutic approaches for asthma. The most effective approaches may be combination therapies that suppress multiple cytokines and a range of redundant and disconnected pathways that separately contribute to asthma pathogenesis. Astute application of these approaches may eventually lead to the development of effective asthma therapeutics. Here we review the current state of knowledge in the field.
Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin (1998)

The compaction level of arrays of nucleosomes may be understood in terms of the balance between the self-repulsion of DNA (principally linker DNA) and countering factors including the ionic strength and composition of the medium, the highly basic N termini of the core histones, and linker histones. However, the structural principles that come into play during the transition from a loose chain of nucleosomes to a compact 30-nm chromatin fiber have been difficult to establish, and the arrangement of nucleosomes and linker DNA in condensed chromatin fibers has never been fully resolved. Based on images of the solution conformation of native chromatin and fully defined chromatin arrays obtained by electron cryomicroscopy, we report a linker histone-dependent architectural motif beyond the level of the nucleosome core particle that takes the form of a stem-like organization of the entering and exiting linker DNA segments. DNA completes approximately 1.7 turns on the histone octamer in the presence and absence of linker histone. When linker histone is present, the two linker DNA segments become juxtaposed approximately 8 nm from the nucleosome center and remain apposed for 3-5 nm before diverging. We propose that this stem motif directs the arrangement of nucleosomes and linker DNA within the chromatin fiber, establishing a unique three-dimensional zigzag folding pattern that is conserved during compaction. Such an arrangement with peripherally arranged nucleosomes and internal linker DNA segments is fully consistent with observations in intact nuclei and also allows dramatic changes in compaction level to occur without a concomitant change in topology.
Treatment of Choroidal Neovascularization Associated With Best's Disease in Children (2009)

The development of secondary choroidal neovascularization in Best's disease is rare in the pediatric population. A retrospective review of pediatric patients with choroidal neovascularization secondary to Best's disease was performed. The patients' courses and treatments were recorded. Three patients with choroidal neovascularization were identified. All had decreased vision and were treated in an individual manner. Vision improved after treatment in all patients. Treatment may hasten resolution of choroidal neovascularization and improve vision.