gebhart/patrepeval huggingface dataset:
A Benzenesulfonamide-Based Mitochondrial Uncoupler Induces Endoplasmic Reticulum Stress and Immunogenic Cell Death in Epithelial Ovarian Cancer (2021)

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancies and requires new therapeutic strategies to improve clinical outcomes. EOC metastasizes in the abdominal cavity through dissemination in the peritoneal fluid and ascites, efficiently adapt to the nutrient-deprived microenvironment, and resist current chemotherapeutic agents. Accumulating evidence suggests that mitochondrial oxidative phosphorylation is critical for the adaptation of EOC cells to this otherwise hostile microenvironment. Although chemical mitochondrial uncouplers can impair mitochondrial functions and thereby target multiple, essential pathways for cancer cell proliferation, traditional mitochondria uncouplers often cause toxicity that precludes their clinical application. In this study, we demonstrated that a mitochondrial uncoupler, specifically 2,5-dichloro-<i>N</i>-(4-nitronaphthalen-1-yl)benzenesulfonamide, hereinafter named Y3, was an antineoplastic agent in ovarian cancer models. Y3 treatment activated AMP-activated protein kinase and resulted in the activation of endoplasmic reticulum stress sensors as well as growth inhibition and apoptosis in ovarian cancer cells <i>in vitro</i> Y3 was well tolerated <i>in vivo</i> and effectively suppressed tumor progression in three mouse models of EOC, and Y3 also induced immunogenic cell death of cancer cells that involved the release of damage-associated molecular patterns and the activation of antitumor adaptive immune responses. These findings suggest that mitochondrial uncouplers hold promise in developing new anticancer therapies that delay tumor progression and protect patients with ovarian cancer against relapse.
An Expeditious Total Synthesis of the Natural Stereomeric Mixture of Stenusine Following a Possible Biogenetic Pathway (2000)

New insight into the biogenetic origin of stenusine 1, the spreading agent of the beetle Stenus comma, is gained from the results of a one-pot synthesis of the natural and the racemic compound [Eq. (1)]. On the basis of these results a plausible biogenetic pathway to 1 is proposed.
Bits, bytes en bugs. Tendensen en nieuwe profielen in de informaticasector in België (1999)

Wie regelmatig de vacaturepagina’s en aanverwante websites consulteert, weet het wel. De bedrijfswereld en andere organisaties zijn koortsachtig op zoek naar informatici. En dat geldt in het bijzonder voor bedrijven uit de informaticasector. Het arbeidsmarktprobleem van deze sector is niet alleen van kwantitatieve aard. Het snel veranderende informatietechnologisch landschap zet ook de bestaande kwalificatiestructuur onder druk. Om de bugs te verwijderen uit het arbeidsmarktprogramma van de sector, dringt een actieprogramma zich op. Aan de aanmaak van dergelijk programma moet echter een grondige analyse vooraf gaan. Dit rapport wil daartoe een bijdrage leveren. 'Bits, bytes en bugs' is het resultaat van een opdracht van CEVORA (Opleidingsfonds van het Aanvullend Paritair Comité voor de Bedienden). In dit rapport wordt ondermeer de tewerkstellingssituatie van de IT-sector in kaart gebracht. Daartoe is het nodige cijfermateriaal bijeengezocht en becommentarieerd. Tevens wordt op meer kwalitatieve wijze ingegaan op recente trends en ontwikkelingen. In dit rapport zijn ook twee beroepsprofielen opgenomen. De activiteiten van de PC-engineer en de internet-ontwikkelaar en de daarbij horende kennis en vaardigheden worden geïnventariseerd en toegelicht.
Evaluation of luciferase reporter bacteriophage A511::luxAB for detection of Listeria monocytogenes in contaminated foods (1997)

A511::luxAB is a recombinant derivative of a broad-host-range bacteriophage specific for the genus Listeria, transducing bacterial bioluminescence into infected cells. In this study, we have evaluated its use for rapid and easy testing of contaminated foods and environmental samples for the presence of viable Listeria cells, in comparison to the standard plating procedure. With a short preenrichment step of 20 h, the system was capable of detecting very low initial contamination rates in several foods artificially contaminated with Listeria monocytogenes Scott A cells. In ricotta cheese, chocolate pudding, and cabbage, less than one cell per g of food could be clearly identified by comparing the light emission of phage-infected samples to that of controls without lux phage. In foods having a large and complex microbial background flora, such as minced meat and soft cheese, at least 10 cells per g were necessary to produce a positive bioluminescence signal. Of 348 potentially contaminated natural food and environmental samples, 55 were found to be Listeria positive by the lux phage method. The standard plating procedure detected 57 positive samples. Some differences were observed with respect to the individual samples, i.e., the lux phage procedure detected more positive samples among the dairy products and environmental samples, whereas the plating procedure revealed more contaminated meat and poultry samples. Overall, both methods performed similarly, i.e., were equally sensitive. However, the minimum time required for detection of Listeria with the luciferase phage assay was 24 h, which is much shorter than the 4 days needed by the standard plating method. Furthermore, a most probable number technique with three parallels, based on the use of A511::luxAB for differentiation of positive and negative tubes, is described. The method enables rapid enumeration of low levels of Listeria cells in several foods tested, against the background of a competing microflora.
Cathode Stability Provided by New Electrolyte containing Cyano‐benzimidazole‐based Lithium Salt: Insights From In Situ DRIFTS Analysis (2016)

Abstract New electrolytes with good thermal and electrochemical stabilities can improve lithium‐ion batteries for applications at high temperatures and high‐potential working conditions. In this study, the solid–electrolyte interphase (SEI) formed in the presence of the new 5‐cyano‐bis(trifluoroborane)‐trifluoromethyl‐benzimidazole lithium salt is examined on two cathodes, that is, commercial LiCoO 2 and Li‐rich Li 1.2 Ni 0.2 Mn 0.6 O 2 cathodes, using in situ diffuse reflectance infrared Fourier‐transform spectroscopy (DRIFTS). The SEI species contain no decomposition products related to the new electrolyte, up to a potential of 5.0 V. During the first charging process, SEI formation starts at an onset potential of 4.4 or 4.5 V for LiCoO 2 or Li 1.2 Ni 0.2 Mn 0.6 O 2 , respectively, which is higher than that observed by using commercial LiPF 6 electrolyte. SEI species of acid anhydride, alkyl carbonates, and Li 2 CO 3 are identified at and beyond the onset potential, which can be attributed to the decomposition of organic carbonates. Furthermore, SEI formation is relatively insignificant in the second‐cycle charging, indicating the formation of a passivating layer in the first cycle, in contrast to the continuing SEI formation through cycling with LiPF 6 electrolyte. The different SEI formed with the new electrolyte can be attributed to the adsorption of the electrolyte anion on the electrode surface. This study demonstrates changes in SEI formation chemistry with the new electrolyte, which appears to be a suitable candidate for transition‐metal‐oxide cathodes at high voltage conditions.
Refining Diagnosis Paths for Medical Diagnosis based on an Augmented Knowledge Graph (2022)

Medical diagnosis is the process of making a prediction of the disease a patient is likely to have, given a set of symptoms and observations. This requires extensive expert knowledge, in particular when covering a large variety of diseases. Such knowledge can be coded in a knowledge graph -- encompassing diseases, symptoms, and diagnosis paths. Since both the knowledge itself and its encoding can be incomplete, refining the knowledge graph with additional information helps physicians making better predictions. At the same time, for deployment in a hospital, the diagnosis must be explainable and transparent. In this paper, we present an approach using diagnosis paths in a medical knowledge graph. We show that those graphs can be refined using latent representations with RDF2vec, while the final diagnosis is still made in an explainable way. Using both an intrinsic as well as an expert-based evaluation, we show that the embedding-based prediction approach is beneficial for refining the graph with additional valid conditions.
New characterization and modeling approach for NBTI degradation from transistor to product level (2007)

From extensive set of silicon data presented in this study, we report a new way of understanding and modeling various aspects of NBTI degradation from transistor to product level. This work opens new paths for both relevant process improvements and product optimization.
High-Resolution XRD Evaluation of Thick 4H-SiC Epitaxial Layers (2001)

4H-SiC commercial wafers and sublimation grown epitaxial layers with a thickness of 100 mum have been studied concerning crystalline structure. The substrate wafers and the epitaxial layers have been separately investigated by high-resolution x-ray diffraction (HRXRD) and synchrotron white beam x-ray topography (SWBXT). The results show that the structural quality was improved in the epitaxial layers in the and directions, concerning domain distribution, lattice plane misorientation, mosaicity, and strain? compared with the substrates. Misoriented domains have merged together to form larger domains while the tilt between the domains was reduced, which resulted in non-splitting in diffraction curves. It is also clear that if the misorientation in the substrate gets too large, we can only see a slight decrease in the misorientation in the layer. At some positions on the substrates there were block structure (mosaicity). omega -rocking curves from epilayers at the same position showed smaller full width at half-maximum (FWHM) values and more uniform and narrow peaks. Curvature was almost the same in grown epilayers compared with the substrates. The shape of the grown epitaxial layers nas concave similarly to the substrates.
Driving Style: How Should an Automated Vehicle Behave? (2019)

This article reports on a study to investigate how the driving behaviour of autonomous vehicles influences trust and acceptance. Two different designs were presented to two groups of participants (n = 22/21), using actual autonomously driving vehicles. The first was a vehicle programmed to drive similarly to a human, “peeking” when approaching road junctions as if it was looking before proceeding. The second design had a vehicle programmed to convey the impression that it was communicating with other vehicles and infrastructure and “knew” if the junction was clear so could proceed without ever stopping or slowing down. Results showed non-significant differences in trust between the two vehicle behaviours. However, there were significant increases in trust scores overall for both designs as the trials progressed. Post-interaction interviews indicated that there were pros and cons for both driving styles, and participants suggested which aspects of the driving styles could be improved. This paper presents user information recommendations for the design and programming of driving systems for autonomous vehicles, with the aim of improving their users’ trust and acceptance.
Parametrization and Effectiveness of Moving Target Defense Security Protections within Industrial Control Systems (2017)

Critical infrastructure systems continue to foster predictable communication patterns and static configurations over extended periods of time. The static nature of these systems ease the process of gathering reconnaissance information that can be used to design, develop and launch attacks by adversaries. In this research effort, the early phases of an attack vector will be disrupted by randomizing port numbers, IP addresses, and communication paths dynamically through the use of overlay networks. These protective measures convert static systems into "moving targets," adding an additional layer of defense. Moving Target Defense (MTD) is an active area of research that periodically changes the attack surface of a system to create uncertainty and increase the workload for an adversary. To assess the effectiveness of MTD strategies within a critical infrastructure environment, performance metrics have been captured to quantify the impacts introduced to the opera- tional network and to the adversary. The MTD strategies have been designed to be crash tolerant and Byzantine fault tolerant to improve their resilience in an operational setting. Optimizing the parameters of network based MTD techniques, such as the frequencies of reconfiguration, while minimizing the impact to the operational network is the focus of this research.
WILLIAM RUFUS (2009)

About this time, Roger de Montgomery, who with a large and powerful body of Barons supported the pretensions of Robert duke of Normandy, destroyed the town of Cambridge with fire and sword.
Star-Graph based multistage interconnection network for ATM switch fabric (2002)

This paper considers a multistage interconnection network based on the Indirect Star Graph topology as a candidate for an ATM (Asynchronous Transfer Mode) switch fabric. We consider both buffered and unbuffered versions of the indirect star. The performance of three existing routing algorithms is studied, and it is found that the packet acceptance probability offered by these algorithms is unsatisfactory. We propose two solutions to alleviate the problem: a modification of the indirect star topology, which we call Star Net; and an adaptive routing algorithm based on the concept of packet priorities. We study the performance of the proposed performance enhancement schemes through simulation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Robust fixed-structure controller synthesis using the implicit small gain bound (1997)

We explore the applicability of the implicit small gain guaranteed cost bound for controller synthesis. For flexibility in controller synthesis, we adopt the approach of fixed-structure controller design which allows consideration of arbitrary controller structures, including order, internal structure, and decentralization. A numerical example that has been addressed by means of alternative guaranteed cost bounds is presented to demonstrate the fixed-structure/implicit small gain approach to robust controller synthesis.
Spherical Carbon‐Coated Natural Graphite as a Lithium‐Ion Battery‐Anode Material (2003)

Eine bequeme Art der Energiespeicherung sind Lithium-Batterien, allerdings sind ihre Anoden aus natürlichem Graphit nicht vereinbar mit Elektrolyten auf Carbonat-Basis. Die Randflächen werden vom Elektrolyt angegriffen, wohingegen die Basisflächen inert bleiben. Durch Anwendung einer neuen Technik erhält man sphärische Graphitpartikel, sodass die Grundfläche maximiert und die Randflächen minimiert werden (siehe Bild). Auf diese Weise wird nur eine kleine Menge Beschichtung benötigt, um den Graphitkern vor dem Elektrolyt zu schützen.
Measurement of typical speech and background noise levels in university classrooms during lectures (1997)

A measurement system has been developed for determining typical long-term speech and background noise levels in university classrooms during lectures. A particular objective was to determine typical levels of student activity noise. A total of 18 lectures were recorded at up to four positions in 14 classrooms. These recordings were digitized and filtered using digital octave-band and A-weighting filters. Software processed the resulting pressure time histories as follows: The signals were squared; short-term mean-square pressures were calculated; sound-pressure levels were calculated; sound-pressure-level frequency distributions were determined and plotted; and the resulting distributions were fitted by one, two, or three normal-distribution curves to identify peaks. Three curves generally gave the best fit. The levels of the peaks so identified were associated with speech, student activity, and background noise levels. The corresponding values were determined for each test case; the results are summarized and conclusions are drawn.
The Photophysics of Polythiophene Nanoparticles for Biological Applications (2018)

In this work the photophysics of poly(3-hexylthiophene) nanoparticles (NPs) is investigated in the context of their biological applications. The NPs, made as colloidal suspensions in aqueous buffers, present a distinct absorption band in the low-energy region. On the basis of systematic analysis of absorption and transient absorption (TA) spectra taken under different pH conditions, this band is associated with charge-transfer states generated by the polarization of loosely bound polymer chains and originating from complexes formed with electron-withdrawing species. Importantly, the ground-state depletion of these states upon photoexcitation is active even on microsecond timescales, thus suggesting that they act as precursor states for long-living polarons; this could be beneficial for cellular stimulation. Preliminary transient absorption microscopy results for NPs internalized within the cells reveal the presence of long-living species, further substantiating their relevance in biointerfaces.
Measurement of Magnetic and Electric Field Inhomogeneities in a Time Projection Chamber Using Laser Tracks (1985)

In a model time projection chamber with a drift length of 1.3 m we study the track distortions caused by inhomogeneous or misaligned fields. The measured coordinate displacements are used to calculate the integrals over the transverse field components; these are found to be in agreement with the independently measured magnetic field.
Att bruka men inte äga : arrende och annan nyttjanderätt till mark i svenskt jordbruk från medeltid till idag (2014)

Att bruka men inte aga : arrende och annan nyttjanderatt till mark i svenskt jordbruk fran medeltid till idag
The Effect of Chloride Ions on the Mechanism of the Oxidative Addition of Cyclic Allylic Carbonates to Pd0 Complexes by Formation of Neutral[(η1‐allyl)PdClL2] Complexes (2005)

Abstract The reversible oxidative addition of a cyclic allylic carbonate cis ‐ 1 to palladium(0) complexes ligated by PPh 3 is affected by chloride ions in DMF or chloroform. In the presence of chloride ions, the oxidative addition may become irreversible and the rate of isomerization of cis ‐ 1 to trans ‐ 1 is slowed down. This is a consequence of a slower isomerization of the cationic complex [(η 3 ‐allyl)Pd(PPh 3 ) 2 ] + ( cis ‐ 2 + ) to trans ‐ 2 + due to the formation of neutral [(η 1 ‐allyl)PdCl(PPh 3 ) 2 ] ( cis ‐ 3 / trans ‐3 ) complexes. Such complexes are formed instead of the cationic cis ‐ 2 + and trans ‐ 2 + whatever the source of chloride ions, i.e., whether voluntarily added to the cationic complexes cis ‐ 2 + and trans ‐ 2 + , voluntarily added in the oxidative addition of cis ‐ 1 with Pd 0 complexes ligated to PPh 3 , or introduced in the dimeric complexes [(η 3 ‐allyl)Pd(μ‐Cl)] 2 ( cis‐ 5 / trans ‐ 5 ). (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2005)
Electronic realization of coarse integral volumetric imaging with wide viewing angle (2010)

This paper proposes an electronic version of coarse integral volumetric imaging (CIVI) display with wide viewing angle. CIVI is a 3D display solution which combines multiview techniques based on integral imaging with volumetric techniques using multilayer panels. Though CIVI has solved most of the major problems of conventional 3D displays, it still has two shortcomings to be overcome. One is the difficulty in realizing electronic display due to unavailability of electronic color display panels transparent enough to be layered for volumetric imaging. The other is the limited viewing angle because of the aberration of lenses. As for the former problem the simplest way to attain electronic version of CIVI is to use half mirrors to merge multiple images from different depths. Though high quality 3D image can be attained with this method, the system size becomes large. To avoid bulky mirror system and realize compact system size, the authors propose layered use of a color panel and multiple monochrome panels to emulate color volumetric display. To expand viewing angle, the authors propose a display system where smaller CIVI display components, each of which has little aberration, are connected so that each display plane faces toward the center of the image optically generated.
Selective kidney targeting increases the efficacy of mesenchymal stromal/stem cells for alleviation of murine stenotic‐kidney senescence and damage (2022)

Chronic ischemia triggers senescence in renal tubules and at least partly mediates kidney dysfunction and damage through a p16<sup>Ink4a</sup> -related mechanism. We previously showed that mesenchymal stromal/stem cells (MSCs) delivered systemically do not effectively decrease cellular senescence in stenotic murine kidneys. We hypothesized that selective MSC targeting to injured kidneys using an anti-KIM1 antibody (KIM-MSC) coating would enhance their ability to abrogate cellular senescence in murine renal artery stenosis (RAS). KIM-MSC were injected into transgenic INK-ATTAC mice, which are amenable for selective eradication of p16<sup>Ink4a+</sup> cells, 4 weeks after induction of unilateral RAS. To determine whether KIM-MSC abolish p16<sup>Ink4a</sup> -dependent cellular senescence, selective clearance of p16<sup>Ink4a+</sup> cells was induced in a subgroup of RAS mice using AP20187 over 3 weeks prior to KIM-MSC injection. Two weeks after KIM-MSC aortic injection, renal senescence, function, and tissue damage were assessed. KIM-MSC delivery decreased gene expression of senescence and senescence-associated secretory phenotype factors, and improved micro-MRI-derived stenotic-kidney glomerular filtration rate and perfusion. Renal fibrosis and tubular injury also improved after KIM-MSC treatment. Yet, their efficacy was slightly augmented by prior elimination of p16<sup>Ink4a+</sup> senescent cells. Therefore, selective targeting of MSC to the injured kidney markedly improves their senolytic potency in murine RAS, despite incomplete eradication of p16<sup>+</sup> cells. KIM-MSC may constitute a useful therapeutic strategy in chronic renal ischemic injury.
Governing Images: The Politics of Film and Video Distribution in Late-Apartheid and Postapartheid South Africa (2007)

Research Article| April 01 2007 Governing Images: The Politics of Film and Video Distribution in Late-Apartheid and Postapartheid South Africa PATRICK LYNN RIVERS PATRICK LYNN RIVERS Search for other works by this author on: This Site Google Journal of Film and Video (2007) 59 (1): 19–31. https://doi.org/10.2307/20688546 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation PATRICK LYNN RIVERS; Governing Images: The Politics of Film and Video Distribution in Late-Apartheid and Postapartheid South Africa. Journal of Film and Video 1 January 2007; 59 (1): 19–31. doi: https://doi.org/10.2307/20688546 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveUniversity of Illinois PressJournal of Film and Video Search Advanced Search The text of this article is only available as a PDF. Copyright © 2007 Board of Trustees of the University of Illinois2007 Article PDF first page preview Close Modal You do not currently have access to this content.