gebhart/patrepeval huggingface dataset:
Molecular cloning and characterization of LZIC, a novel gene encoding ICAT homologous protein with leucine zipper domain (2001)

ICAT inhibits the interaction between beta-catenin and TCF transcription factors. As ICAT might be a tumor suppressor gene with the potential to negatively regulate the WNT - beta-catenin - TCF signaling pathway, ICAT related gene in the human genome draft sequence was searched for. Here, the LZIC gene, a novel gene encoding a 190-amino-acid polypeptide with leucine zipper domain and ICAT homologous domain, was cloned and characterized. Amino-acid identity between LZIC and ICAT in the ICAT homologous domain was 38%. The LZIC gene, consisting of at least 8 exons, was located in the human chromosome 1p36.32-pter region. The major 5.2-kb LZIC mRNA and minor 2.1-, 1.6-, and 1.0-kb LZIC mRNAs were expressed almost ubiquitously in normal human tissues. LZIC was expressed in all cancer cell lines examined in this study, and was significantly up-regulated in a gastric cancer cell line MKN74 and 5 cases of primary gastric cancer. As LZIC contains ICAT homologous domain, LZIC might inhibit the interaction between beta-catenin and TCF transcription factors, just like ICAT, and, up-regulation of LZIC in gastric cancer might be due to a negative feed-back mechanism to inhibit the WNT - beta-catenin - TCF signaling pathway.
Endoscopic Inferior Turbinate Reduction: An Outcomes Analysis (2001)

These results confirm the long-term effectiveness of this procedure for the relief of nasal obstruction.
Faraday effect measurements of holmium oxide (Ho2O3) ceramics-based magneto-optical materials (2018)

Faraday effect measurements of holmium oxide (Ho 2 O 3 ) ceramics-based magneto-optical materials, highly potential material candidates for high-energy laser Faraday isolators, are presented in this paper. Temperature dependence of the Verdet constant of nondoped Ho 2 O 3 ceramics was measured for temperatures 15–305 K at $1.064~\unicode[STIX]{x03BC}\text{m}$ wavelength. The Verdet constant dispersion for wavelengths 0.5– $1~\unicode[STIX]{x03BC}\text{m}$ and $1.064~\unicode[STIX]{x03BC}\text{m}$ was measured for both nondoped Ho 2 O 3 ceramics and Ho 2 O 3 ceramics doped with terbium Tb 3+ (0.2 at. %) and cerium Ce 3+ (0.1 at. %) ions. The results suggest that the relatively low level of doping of Ho 2 O 3 with these ions has no significant boosting impact on the Faraday effect. Therefore, other compositions of Ho 2 O 3 ceramics-based magneto-optical materials, as well as various doping concentrations, should be further examined.
Evaluation of cell proliferation in breast carcinoma. Comparison of Ki-67 immunohistochemical study, DNA flow cytometric analysis, and mitotic count (1990)

Growth kinetics of 102 breast carcinomas were studied by immunohistochemical analysis with the monoclonal antibody Ki-67, which reacts with a nuclear antigen in proliferating cells. The results were correlated with ploidy and S-phase fraction (SPF) analyzed by DNA flow cytometric study and with mitotic count analyzed by light microscopic study. The proportion of Ki-67-positive cells (Ki-67 score) in breast carcinomas varied from 0.6% to 80% (median, 6.3%). Ki-67 scores were significantly higher in the DNA aneuploid than in the DNA diploid tumors. Ki-67 scores correlated significantly with tumor SPF in DNA aneuploid tumors. In DNA diploid tumors SPF showed no correlation with Ki-67 score. High Ki-67 scores were associated with high mitotic counts (P less than 0.0001) and histologic grade (P less than 0.0001). Nuclear pleomorphism, tubule formation, or lymph node status were not correlated with Ki-67 score. In conclusion, Ki-67 immunostaining correlates with other measures of cell proliferation (SPF, mitotic count) supporting its clinical significance.
Magnetic Peroxyborates. The Pseudo-Superoxides (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMagnetic Peroxyborates. The Pseudo-SuperoxidesRebecca Bruce, John O. Edwards, David Griscom, Robert A. Weeks, Leonard R. Darbee, William DeKleine, and Michael McCarthyCite this: J. Am. Chem. Soc. 1965, 87, 9, 2057–2059Publication Date (Print):May 1, 1965Publication History Published online1 May 2002Published inissue 1 May 1965https://pubs.acs.org/doi/10.1021/ja01087a042https://doi.org/10.1021/ja01087a042research-articleACS PublicationsRequest reuse permissionsArticle Views49Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Profiling-Based Log Block Replacement Scheme in FTL for Update-Intensive Executions (2011)

FTL (Flash Translation Layer) hides details of flash memory, providing file systems with an abstract view of the flash memory. For NAND flash memory, some previous researches have achieved dramatic performance enhancement by adopting log-based FTL, which records time-consuming write operations in log blocks, rather than executes them immediately. Log block replacement scheme plays an essential role in this method, due to the limitation of pre-reserved log block space, this method entails selecting some victims from the existing blocks and re-use them for newly issued operations. However, simple replacement algorithms are vulnerable to select such log blocks that will be used soon, which causes performance degradation. In this paper we propose a smarter log block replacement scheme to alleviate this problem by keeping busy log blocks from being selected, based on profiling and analyzing log block status. We show that our scheme reduces unnecessary time-consuming write operations and achieves performance improvement especially for the applications having intensive locality.
ChemInform Abstract: Convenient Synthesis of Propane Aminophosphonic Acids, Aminodiphosphonic Acids and Their Structural Analogues, Mediated by Azetidinium Salts. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bieyclic bases . Synthesis and stereochemical studies of chiral 5‐substituted N‐tosyl‐2‐azabicyclo[2.2.1[ heptanes (1971)

Abstract The synthesis of chiral exo and endo 5‐sulbstituted N ‐losyl‐2‐azabicyclo[2.2.1]heptanes is reported. The nearly identical exo‐endo equilibrium ratios of the title compounds and the carbocyclic analogs suggest that their geometries and sterie interactions are quite similar.
Mechanical responses of the basilar membrane. (1996)

The traveling-wave activity that Georg von Békésy studied in the cochlea early in this century has been of intense interest to physiologists and mathematical modelers over the last 30 years. This interest was nurtured by the discovery that the mechanical responses of the basilar membrane are nonlinear at relatively low sound levels and that the nonlinearity is dependent on biological processes [W. S. Rhode, J. Acoust. Soc. Am. Suppl. 1 49, S1218 (1971)]. This review will briefly summarize the major findings of the early years as background to a presentation of several issues that are the focus of contemporary work. The steady-state and transient velocity responses of the basilar membrane characterize the capacity of the biological amplification mechanism in the organ of Corti and indicate that a ‘‘gain’’ of 40–60 dB is provided by the outer hair cells. Considerable response distortion accompanies this gain, and wave propagation of certain distortion products occurs. Electrical stimulation of the outer hair cells provides evidence of their mechanical role in the amplification mechanism by demonstration of the frequency range and displacement capacity of the cells. Efferent innervation of the organ of Corti is found to modulate the mechanical activity of the system.
Complex changes in cellular inositol phosphate complement accompany transit through the cell cycle (2004)

Inositol polyphosphates other than Ins(1,4,5)P3 are involved in several aspects of cell regulation. For example, recent evidence has implicated InsP6, Ins(1,3,4,5,6)P5 and their close metabolic relatives, which are amongst the more abundant intracellular inositol polyphosphates, in chromatin organization, DNA maintenance, gene transcription, nuclear mRNA transport, membrane trafficking and control of cell proliferation. However, little is known of how the intracellular concentrations of inositol polyphosphates change through the cell cycle. Here we show that the concentrations of several inositol polyphosphates fluctuate in synchrony with the cell cycle in proliferating WRK-1 cells. InsP6, Ins(1,3,4,5,6)P5 and their metabolic relatives behave similarly: concentrations are high during G1-phase, fall to much lower levels during S-phase and rise again late in the cycle. The Ins(1,2,3)P3 concentration shows especially large fluctuations, and PP-InsP5 fluctuations are also very marked. Remarkably, Ins(1,2,3)P3 turns over fastest during S-phase, when its concentration is lowest. These results establish that several fairly abundant intracellular inositol polyphosphates, for which important biological roles are emerging, display dynamic behaviour that is synchronized with cell-cycle progression.
Theoretical Simulation of Deformed Carbon Nanotubes with Adsorbed Metal Atoms: Enhanced Reactivity by Deformation (2011)

Simulations adopting the generalized gradient approximation in the density functional theory were performed to investigate the reaction of carbon nanotubes with adsorbed metal atoms. Mechanical modification of the structure of carbon nanotubes enhances their chemical reactivity. Adsorption of W, Ta, or Nb on a (5,0) nanotube with a Stone–Wales defect was shown to have characteristically strong chemisorption. Bond-breaking in the C–C network and formation of a local metal–carbon complex were observed during the simulation. The adsorption of W, Ta, Nb, or Mo on a twisted (5,0) nanotube showed a preferred breaking of several bonds, even creating an opening in the wall. The enhanced chemical reactivity of deformed nanotubes is characterized by the formation of a metal–carbon complex. Applications of the reaction are suggested.
Biosynthetic arginine decarboxylase in Escherichia coli is synthesized as a precursor and located in the cell envelope (1985)

The biosynthetic form of arginine decarboxylase (ADC) catalyzes the synthesis of agmatine, a precursor of putrescine, in Escherichia coli. Selective disruption of the cell envelope and an assessment of ADC activity or immunoprecipitable ADC in various fractions demonstrated its location between the cytoplasmic membrane and peptidoglycan layer. Expression in minicells of the speA gene encoding ADC resulted in the production of two immunoprecipitable species (74 and 70 kilodaltons). Studies in vivo with a pulse and chase of radiolabeled amino acid into the two species suggest a precursor-product relationship. This relationship was corroborated by demonstrating the accumulation of the 74-kilodalton species in a strain of E. coli unable to process signal sequences. Peptide mapping experiments with V8 protease, trypsin, and alpha-chymotrypsin demonstrated that the two species of ADC were very similar except for a minor difference. These data were used to substantiate the compartmentalization hypothesis as to how exogenous arginine can be channeled preferentially into putrescine.
Assessing the fault-detecting ability of testing methods (1991)

Article Free Access Share on Assessing the fault-detecting ability of testing methods Authors: Phyllis G. Frankl Computer Science Dept., Polytechnic University, 333 Jay St., Brooklyn, N.Y Computer Science Dept., Polytechnic University, 333 Jay St., Brooklyn, N.YView Profile , Elaine J. Weyuker Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, NY Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, NYView Profile Authors Info & Claims SIGSOFT '91: Proceedings of the conference on Software for citical systemsSeptember 1991 Pages 77–91https://doi.org/10.1145/125083.123056Published:01 September 1991Publication History 14citation361DownloadsMetricsTotal Citations14Total Downloads361Last 12 Months12Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Time- and space-resolved measurements of soft X-ray emission viewed 4/spl deg/ from the z axis at Z (1999)

Summary form only given, as follows. We have developed a near-axis time-resolved X-ray imaging capability to make measurements of the emission profile for foam targets on the Z accelerator. By slit-imaging spectrally filtered X-ray emission from the Z-pinch target to an array of scintillator coupled fiber-optics, we obtain an emission profile as a function of time sampling every 260 /spl mu/m viewing 4/spl deg/ from the z axis. The plasma run in and re-expansion are observed. Implosion velocities, and compressed sizes for annular and foam targets have been measured. We describe the diagnostics, results from the instrument and instrument characterization.
Identification of mutagenic compounds in extracts of diesel exhaust particulates. Paper 81. 56. 1 (1981)

Exhaust gases form diesel engines were analyzed using different approaches and instruments to study the complex mixture of carbonaceous matter and gaseous components. The results demonstrate that a number of oxygenated polynuclear aromatic hydrocarbons (PAH) are present and also readily react with dilute nitric acid, particularly pyrene. They form nitrate derivatives which are powerful mutagens. 5 refs.
Studies on Some Benzoxazine-4-one Derivatives with Potential Biological Activity (2012)

2-(4-Toluenesulphonyloxy phenyl)-3,1-benzoxazine-4-one <b>2</b> was prepared and reacted with some nitrogen nucleophiles, e.g., ammonia, <i>o</i>-phenylendiamine, some heterocyclic amines, hydrazine hydrate and hydroxylamine hydrochloride and sulphur nucleophile, e.g., phosphorous pentasulphide. Structures of the newly synthesized compounds were established by elemental analysis and spectral data. All new prepared compounds were subjected to antimicrobial activity evaluation where compounds, <b>8</b>, <b>9</b>, <b>10</b> and <b>18 </b>exhibited good activities against <i>Bacillus Thuringenesis</i> and <b>5</b>, <b>10</b>, <b>11</b>, <b>14</b>, <b>15</b>, <b>17</b> and <b>18</b> exhibited good activities against <i>Klebseilla Pneumonia</i>. On the other hand, the results for antifungal activities revealed that, compounds <b>5</b>, <b>6</b>, <b>7</b>, <b>16</b> and <b>17</b> exhibited good activities against <i>Trichoderma Herzianum</i> and <i>Trichoderma Virdi</i>.
Results from the simultaneous processing of modified in situ retorts 7 and 8 (1983)

Occidental Oil Shale, Inc., recently completed the demonstration of mining, rubblization, ignition, and simultaneous processing of two commercial-size modified in situ (MIS) retorts at its Logan Wash Facility near De Beque, Colorado. The retorts were constructed with an average rubble void of 18.5 percent in the low-grade shale (17 gallons per ton) at this site. Total product yield averaged 70 percent of the Fischer Assay oil-in-place in the target rubble in the two retorts.
Predicting Breakdown Pressure and Breakdown Cycle in Cyclic Fracturing (2018)

Summary In hydraulic fracturing, large volumes of fluid and sand are injected into the formation to enhance its transport properties. In conventional fracturing, the fluid pressure is increased monotonically to reach failure in a single cycle. The breakdown pressure can be reduced if we increase and decrease the fluid pressure cyclically (cyclic fracturing). This phenomenon has been tested in other engineering fields, but it is not yet possible to predict the breakdown pressure and cycle in petroleum engineering in the context of hydraulic fracturing. In the present study, we propose a workflow that is based on a modified Paris law to predict the breakdown pressure and the number of cycles in cyclic fracturing. The modified Paris law is based on linear-elastic fracture mechanics (LEFM), which treats the solid domain as an isotropic and linear-elastic medium. We use the data available in the literature for dry Tennessee Sandstone. The samples were hydraulically fractured under triaxial stress, two with conventional and two with cyclic methods. The results show that the tuned Paris law can predict the breakdown pressure and cycle with a good accuracy. The tuned model can help us to design an optimal scenario that is fundamentally different from the conventional method for formation stimulation.
Urine Nicotine Metabolites and Smoking Behavior in a Multiracial/Multiethnic National Sample of Young Adults (2007)

Nicotine metabolism has been hypothesized to affect patterns of smoking. The recent development of a noninvasive measure of nicotine metabolism, the nicotine metabolite ratio (trans-3'-hydroxycotinine/cotinine), makes it possible to examine the association between rate of nicotine metabolism and smoking behavior in the general population. This US study examined group differences in the ratio measured in urine and the association between the ratio and multiple measures of smoking behavior and nicotine dependence in a large, national representative sample of young adults. The sample included 900 daily smokers aged 18-26 years from wave III (2001-2002) of the National Longitudinal Survey of Adolescent Health. Nicotine dependence was measured by using the Fagerström Test for Nicotine Dependence. Females had higher nicotine metabolite ratios than males; Whites and Hispanics had higher nicotine metabolite ratios than African Americans or Asians. This finding is consistent with those from laboratory studies of older smokers based on intravenous infusion of nicotine. No significant association was found between the nicotine metabolite ratio and number of cigarettes smoked per day or nicotine dependence. The availability of a noninvasive measure makes possible systematic testing of causal hypotheses generated by laboratory studies in the general population.
Performance of the AILES THz-Infrared beamline at SOLEIL for High resolution spectroscopy (2010)

International audience
Review on the Effect of Bottom Ash in Performance of Portland Cement Mortar (2015)

Utilization and suitability of bottom ash in Portland cement have been increasing significantly in recent year. Bottom ash has substantial effects on mechanical properties with different composition of replacement in mixture of bottom ash and Portland cement. Bottom ash was used to determine the feasibility of the substitution as recycling product from industry depending on the percentage of the bottom ash. On the other hand, bottom ash offers a better solution for maintaining materials characteristic of Portland cement mortar and also provide beneficial mechanical performance. The result of using bottom ash in Portland cement mortar showed that it could make better the mechanical properties and hence disposed bottom ash wastes safely in technical, economic and environmental methods.
Protein toxins of Pasteurella pestis. Subunit composition and acid binding (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProtein toxins of Pasteurella pestis. Subunit composition and acid bindingThomas C. Montie and Diane B. MontieCite this: Biochemistry 1971, 10, 11, 2094–2100Publication Date (Print):May 1, 1971Publication History Published online1 May 2002Published inissue 1 May 1971https://pubs.acs.org/doi/10.1021/bi00787a021https://doi.org/10.1021/bi00787a021research-articleACS PublicationsRequest reuse permissionsArticle Views24Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mechanism of protein cleavage at asparagine leading to protein–protein cross-links (2019)

Long-lived proteins (LLPs) are present in numerous tissues within the human body. With age, they deteriorate, often leading to the formation of irreversible modifications such as peptide bond cleavage and covalent cross-linking. Currently understanding of the mechanism of formation of these cross-links is limited. As part of an ongoing study, proteomics was used to characterise sites of novel covalent cross-linking in the human lens. In this process, Lys residues were found cross-linked to C-terminal aspartates that had been present in the original protein as Asn residues. Cross-links were identified in major lens proteins such as αA-crystallin, αB-crystallin and aquaporin 0. Quantification of the level of an AQP0/AQP0 cross-linked peptide showed increased cross-linking with age and in cataract lenses. Using model peptides, a mechanism of cross-link formation was elucidated that involves spontaneous peptide bond cleavage on the C-terminal side of Asn residues resulting in the formation of a C-terminal succinimide. This succinimide does not form cross-links, but can hydrolyse to a mixture of C-terminal Asn and C-terminal Asp amide peptides. The C-terminal Asp amide is unstable at neutral pH and decomposes to a succinic anhydride. If the side chain of Lys attacks the anhydride, a covalent cross-link will be formed. This multi-step mechanism represents a link between two spontaneous events: peptide bond cleavage at Asn and covalent cross-linking. Since Asn deamidation and cleavage are abundant age-related modifications in LLPs, this finding suggests that such susceptible Asn residues should also be considered as potential sites for spontaneous covalent cross-linking.