gebhart/patrepeval huggingface dataset:
The structure and acquisition of English dative constructions (1997)

Tumor necrosis factor-alpha (TNF-alpha) plays a central role in the host's immunomodulatory response to infective agents. To evaluate the TNF-alpha system in patients with chronic hepatitis C virus (HCV) infection, plasma, serum, and peripheral blood mononuclear cells (PBMC) were prospectively collected from 53 patients and 33 healthy control subjects. Circulating TNF-alpha and TNF receptors were assayed by their respective enzyme immunoassays. In addition, TNF-alpha mRNA was quantitated in PBMC using a branched DNA assay, and production of TNF-alpha by PBMC with and without lipopolysaccharide was also assessed. Patients with chronic HCV infection had a higher level of circulating TNF-alpha compared to healthy control subjects (9.62 +/- 6.01 vs 3.66 +/- 1.23 pg/ml, P < 0.001). They also had higher circulating levels of TNF receptors compared to control (CD120a: 3323 +/- 1267, pg/ml, N = 49 vs 1855 +/- 422 pg/ml, N = 33, P < 0.001; CD120b: 1290 +/- 650 pg/ml, N = 51, vs 863 +/- 207 pg/ml, N = 33, P < 0.001). Plasma TNF-alpha level correlated with circulating CD120a (r = 0.52, N = 49, P < 0.001) and weakly with CD120b (r = 0.32, N = 51, P = 0.02). Plasma TNF-alpha also correlated with markers of hepatocellular injury, including ALT (r = 0.34, N = 53, P = 0.01) and alpha-GST (r = 0.31, N = 43, P = 0.042), but not with serum HCV RNA levels. There was no difference in the TNF-alpha mRNA levels in PBMC between patients with chronic HCV infection (1.4 +/- 1.9 units/10[6] cells, N = 8) and healthy control subjects (2.1 +/- 1.4 units/10[6] cells, N = 8, P = NS). There was also no difference in the spontaneous production of TNF-alpha by PBMC (1 x 10[6] cells/ml) between patients with chronic HCV infection (14.2 +/- 36.5 pg/ml, N = 11) and healthy subjects (11.9 +/- 14.0 pg/ml, N = 14, P = NS). However, patients with chronic HCV infection produced more TNF-alpha upon stimulation with lipopolysaccharide compared to healthy control subjects (1278 +/- 693 pg/ml, N = 11, vs 629 +/- 689 pg/ml, N = 14, P < 0.05). These data indicate that the TNF-alpha system is activated in patients with chronic HCV infection.
Liquid chromatographic resolution of 3‐amino‐1,4‐benzodiazepin‐2‐one derivatives on various Pirkle‐type chiral stationary phases (2011)

The two enantiomers of N-acyl amide and N-ureide derivatives of 3-amino-5-phenyl-1,4-benzodiazepin-2-ones, which have been known to show anti-respiratory syncytial virus (RSV) activity, were resolved on seven different Pirkle-type chiral stationary phases (CSPs) with the use of 10% isopropyl alcohol in hexane as a mobile phase. Among the seven Pirkle-type CSPs, the one based on (S)-leucine derivative named as N-Phe-L-Leu was found to be most successful, the separation factors (α) and the resolutions (R(S) ) for seven analytes being in the range of 1.78-4.21 and 5.94-15.08, respectively. By resolving N-benzyloxycarbonyl derivatives of 3-amino-5-phenyl(or 5-methyl)-1,4-benzodiazepin-2-ones on Pirkle-type CSPs, the phenyl ring at the 5-position and the NH hydrogen at the 1-position of analytes were found to play an important role in the chiral recognition.
The pro-apoptotic BAX protein influences cell growth and differentiation from the nucleus in healthy interphasic cells (2017)

It has become more and more evident that the BCL-2 family proteins mediate a wide range of non-apoptotic functions. The pro-apoptotic BAX protein has been reported in interphasic nuclei. Whether the nuclear form of BAX could be involved in non-apoptotic function is still unknown. Our study showed for the first time that BAX was associated with chromatin in vitro. Next, we used gain and loss of function approaches to decipher the potential role of nuclear BAX in non-apoptotic cells. In vitro, nuclear BAX promoted cell proliferation in lung epithelial cells and primary human lung fibroblasts by modulating CDKN1A expression. Interestingly, BAX occupancy of CDKN1A promoter was specifically enriched close to the transcription-starting site. Nuclear BAX also modulated the basal myofibroblastic differentiation and migration of primary human lung fibroblasts. Finally, BAX nuclear localization was associated in vivo with the remodelling of lung parenchyma during development, tumorigenesis as well as fibrosis compared to control adult human lungs. Hence, our study established for the first time, a strong link between the nuclear localization of the pro-apoptotic BAX protein and key basic cellular functions in the non-apoptotic setting.
Micromachined capacitive long-range displacement sensor for nanopositioning of microatuator systems (2004)

This thesis is about a “Micromachined capacitive long-range displacement sensor for nano-positioning of microactuator systems��?. Possible applications of such microsystems are found in future probe-based datastorage, scanning probe microscopy, microbiology, optical lens manipulation, microgrippers and microrobots, etc. These applications require positioning with nanometer precision over a long range (ten’s of micrometers) and benefit from further miniaturization and the application of sub-mm sized Micro Electro Mechanical Systems (MEMS). In many cases open-loop operation is not sufficient and a form of system control is required to combine nanometer accuracy with a large dynamic range and to obtain better system performance. In order to make such systems both economically viable as well as compact, on-chip position sensing appears to be a requirement. The aim is therefore, to obtain optimal performance through an integration of sensor and actuator with micromachining fabrication technology without additional micro assembly. The target specifications for the microsensor were to obtain 1-10 nm accuracy in a range of 100 μm or more i.e. dynamic measurement range of 10^5 or more. For experimental assessment various devices with various periodic geometries were designed for a surface micromachining process. The design integrates electrostatic actuators with a capacitive position sensor in a 5 μm-high poly-silicon structural layer, using one mask. The capacitance between the two geometries on sense-structures and slider is converted to a voltage and measured using a charge amplifier and a synchronous detection technique. For Constant Capacitance Measurement Mode an estimated position uncertainty below 10 nm is demonstrated, although far from real-time operation. However, a position uncertainty of 1 nm or less appears feasible.
<title>Discharge-pumped radiation of xenon dimers</title> (2003)

A discharge in high-pressure xenon excilamps is studied experimentally and theoretically. In the absence of an additional source of xenon preionization, the volume discharge is produced in the form of a diffuse cloud or diffuse cones at pressures of several hundreds of torrs. Under these conditions, radiation is emitted with a high efficiency within the VUV spectral range. The results of simulations have shown that, at the pressure on the order of 100 Torr and the field voltage on the order of 10 kV/cm, the established near-cathode layer is on the order of several tens of microns, which is much less than the wire radius. The cathode layer, the potential drop in the near-cathode area is much lower than the voltage applied to the discharge gap. We put forward a hypothesis that the formation of the volume discharge is due to the presence of dense plasma in the near-cathode area, and this plasma plays the role of a plasma cathode.
Modified Surface-active Monomers for Adhesive Bonding to Dentin (1993)

PMGDM, a PMDM-type adhesive monomer, was synthesized from pyromellitic dianhydride and glycerol dimethacrylate. Only the para isomer of PMDM, a solid, is used in dental adhesives. The adhesive monomer PMGDM is a liquid and consists of a mixture of para- and meta isomers. This study shows that PMGDM has several advantages over PMDM. For example, the adhesive can be applied at a greater thickness, and additives and/or additional initiators for improved curing can be incorporated. Use of the liquid monomer PMGDM also provided a convenient means of varying the thickness of the adhesive layer between dentin and composite. The adhesive bonds were tested in both shear and tensile modes. PMDM was used as the control. The reliability of the bonds, as judged from the Weibull modulus and Weibull characteristic strength, was improved by (1) use of more concentrated solutions of PMGDM adhesive, (2) use of an adhesive thickness of about 25 microns, and (3) modification of PMGDM with a diluent monomer which is expected to enhance the degree of cure and/or the dentin-wetting properties of the adhesive resin.
ЯМР-исследования монокристаллов топологического изолятора Bi-=SUB=-2-=/SUB=-Te-=SUB=-3-=/SUB=- при низких температурах (2017)

Проведены исследования методом ЯМР 125 Te порошкового образца и монокристаллических пластинок топологического изолятора Bi 2 Te 3 при комнатной температуре и при низких температурах в интервале 12.5-16.5 K. Спектры монокристаллических пластинок исследовались в ориентации, в которой кристаллографическая ось c была параллельна или перпендикулярна магнитному полю. Для получения спектров регистрировались сигналы спинового эха и строилась их огибающая. Показано, что спектр ЯМР для порошка теллурида висмута и для пластинок с ориентацией c normal B состоит из двух линий, которые предположительно обусловлены ядрами теллура в двух кристаллографических позициях в объеме образца. Положение и форма линий определяются химическим сдвигом и сдвигом Найта. Для ориентации пластинок c|| B в спектре имеется дополнительная компонента в области высоких частот, которая не может появиться за счет угловой зависимости сдвигов линий, обусловленных ядрами теллура в объеме топологического изолятора. При низкой температуре дополнительная линия доминирует в спектре. Работа выполнена при поддержке РФФИ (гранты N 14-52-12010, 16-57-52009 МНТ, 14-02-92012), в рамках государственного задания ФАНО России (тема "Спин", N 01201463330) при частичной поддержке Комплексной программы УрО РАН (проект N 15-17-2-12), правительства РФ (контракт N 02.A03.21.0006) и Национального научного совета (Тайвань, гранты N 104-2811-M-006-029 и 104-2811-M-006-031). DOI: 10.21883/FTT.2017.05.44368.370
Zero-One Behaviour (2016)

A large group of industrially important polymerization processes is carried out in dispersed systems. These processes differ with respect to their physical nature, mechanism of particle formation, particle morphology, size, charge, types of interparticle interactions, and many other aspects. Polymer dispersions, and polymers derived from polymerization in dispersed systems, are used in diverse areas such as paints, adhesives, microelectronics, medicine, cosmetics, biotechnology, and others. Frequently, the same names are used for different processes and products or different names are used for the same processes and products. The document contains a list of recommended terms and definitions necessary for the unambiguous description of processes, products, parameters, and characteristic features relevant to polymers in dispersed systems.
Working from within: how secretory leukocyte protease inhibitor regulates the expression of pro-inflammatory genes (2021)

Secretory leukocyte protease inhibitor (SLPI) is a small but powerful member of the serine protease inhibitor family, which includes proteins such as elafin and α1-antitrypsin. These proteins all have similar structures and antiprotease abilities, but SLPI has been found to have an additional role as an anti-inflammatory factor. It can inhibit the production of pro-inflammatory cytokines in cells stimulated with lipopolysaccharide, prevent neutrophil infiltration in murine models of lung and liver injury, and regulate the activity of the transcription factor NF-κB. In this review, we will revisit SLPI’s unique biochemistry, and then explore how its anti-inflammatory functions can be linked to more recent findings showing that SLPI can localize to the nuclei of cells, bind DNA, and act as a regulator of gene expression.
Kinetic Effects in the Electrochemistry of Fullerene Derivatives at Very Negative Potentials (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetic Effects in the Electrochemistry of Fullerene Derivatives at Very Negative PotentialsFrancisco Arias, Qingshan Xie, Luis Echegoyen, Yunhui Wu, Qingyi Lu, and Stephen R. WilsonCite this: J. Am. Chem. Soc. 1994, 116, 14, 6388–6394Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ja00093a045https://doi.org/10.1021/ja00093a045research-articleACS PublicationsRequest reuse permissionsArticle Views348Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Huygens Principle for a Uniaxial Dielectric-Magnetic Medium with Gyrotropic-Like Magnetoelectric Properties (2009)

Abstract The dyadic Green functions for a uniaxial dielectric-magnetic medium, together with a reversible field transformation, were implemented to derive a formulation of the Huygens principle appropriate to a uniaxial dielectric-magnetic medium with gyrotropic-like magnetoelectric properties. Keywords: dyadic Green functionscattering theorybianisotropic Notes 1Here and hereafter, vectors are underlined whereas dyadics are double underlined.
Studies on biochemical transformation of plant steroids. Part I. Biochemical interconversion of the Δ25(27)- and the saturated 25D-or 25L-sapogenins (1967)

Some Δ25(27)-sapogenins were isolated from Hosta kiyosumiensis F. Maek. together with the corresponding saturated sapogenins: i.e., Δ25(27)-tigogenin, Δ25(27)-gitogenin, Δ25(27)-manogenin, and Δ25(27)-9(11)-dehydromanogenin. [27-14C]-Δ25(27)-Gitogenin, [27-14C]-gitogenin ([27-14C]-neogitogenin), and [27-14C]-25-hydroxygitogenin were synthesised from Δ25(27)-gitogenin. Each labelled sapogenin thus obtained was incubated with the homogenate from the epigeous part of Hosta kiyosumiensis at 37° for 6–7 hr. The results from these experiments indicate the following interconversion between the unsaturated and the saturated sapogenins occurring by the action of the plant enzyme: Δ25(27)-gitogenin ⇄ gitogenin and/or neogitogenin. It was thus shown that the Δ25(27)-sapogenin is not an artifact but a naturally occurring product. We suggest three classifications of the naturally occurring spirostans: 25D- or R-sapogenin (iso); 25L- or S-sapogenin (neo); 25,27-unsaturated sapogenin.
[Pancreatic hormone amylin and integrity of the gastric mucosa]. (2001)

The paper presents experimental findings of some possible mechanisms of protective antiulcerous action of amyline. Amyline is the second beta-cell pancreatic hormone, which has been just recently discovered. The authors have studied the effects of amyline on gastric secretion, mast cell functions, mesenteric lymphatic microvascular contractility, i.e. on individual aggressive and protective factors of the gastric mucosa. Amyline has been found to inhibit basal acid gastric secretion and the secretion stimulated by vagal irritation. The peptide reduces the secretory activities of mast cells. Amyline given to animals increases the heparin saturation index of mast cells and decreases the degranulation index. Amyline-induced stabilization of mast cells appears to followed by the decreased release of histamine and other damaging substances. The stimulating effect of amyline on the contractile activity of mesenteric lymphatic vessels was recorded in rats. Amyline increases both the frequency and amplitude of their contractions. The increased lymph flow that is closely associated with microcirculation promotes the maintenance of tissue homeostasis. Therefore, the protective antiulcerous properties of amyline reduce the action of aggressive agents on the gastric mucosa and stimulate protective ones.
Phylogenetic Analysis Indicates That Evasin-Like Proteins of Ixodid Ticks Fall Into Three Distinct Classes (2021)

Chemokines are structurally related proteins that activate leucocyte migration in response to injury or infection. Tick saliva contains chemokine-binding proteins or evasins which likely neutralize host chemokine function and inflammation. Biochemical characterisation of 50 evasins from <i>Ixodes</i>, <i>Amblyomma</i> and <i>Rhipicephalus</i> shows that they fall into two functional classes, A and B, with exclusive binding to either CC- or CXC- chemokines, respectively. Class A evasins, EVA1 and EVA4 have a four-disulfide-bonded core, whereas the class B evasin EVA3 has a three-disulfide-bonded "knottin" structure. All 29 class B evasins have six cysteine residues conserved with EVA3, arrangement of which defines a Cys6-motif. Nineteen of 21 class A evasins have eight cysteine residues conserved with EVA1/EVA4, the arrangement of which defines a Cys8-motif. Two class A evasins from <i>Ixodes</i> (IRI01, IHO01) have less than eight cysteines. Many evasin-like proteins have been identified in tick salivary transcriptomes, but their phylogenetic relationship with respect to biochemically characterized evasins is not clear. Here, using BLAST searches of tick transcriptomes with biochemically characterized evasins, we identify 292 class A and 157 class B evasins and evasin-like proteins from Prostriate (<i>Ixodes</i>), and Metastriate (<i>Amblyomma, Dermacentor, Hyalomma</i>, <i>Rhipicephalus</i>) ticks. Phylogenetic analysis shows that class A evasins/evasin-like proteins segregate into two classes, A1 and A2. Class A1 members are exclusive to Metastriate ticks and typically have a Cys8-motif and include EVA1 and EVA4. Class A2 members are exclusive to Prostriate ticks, lack the Cys8-motif, and include IHO01 and IRI01. Class B evasins/evasin-like proteins are present in both Prostriate and Metastriate lineages, typically have a Cys6-motif, and include EVA3. Most evasins/evasin-like proteins in Metastriate ticks belong to class A1, whereas in Prostriate species they are predominantly class B. In keeping with this, the majority of biochemically characterized Metastriate evasins bind CC-chemokines, whereas the majority of Prostriate evasins bind CXC-chemokines. While the origin of the structurally dissimilar classes A1 and A2 is yet unresolved, these results suggest that class B evasin-like proteins arose before the divergence of Prostriate and Metastriate lineages and likely functioned to neutralize CXC-chemokines and support blood feeding.
Tumor infiltration by chemokine receptor 7 (CCR-7)–expressing T lymphocytes to predict outcome in advanced colorectal carcinoma patients. (2011)

e14056 Background: An efficient anti-tumor immune-response is considered a critical factor for a good outcome and a prolonged survival in colorectal cancer patients. The extent of tumor infiltration by different T-lymphocyte subsets, which represents patients’ state of immune-competence, may reflect a completely different outcome. We have evaluated in advanced colorectal cancer patients the prognostic role of tumor infiltration by cytotoxic (CD8+) T cells expressing the chemokine receptor 7 (CCR7). We also investigated if the presence of this lymphocyte subset might correlate with tumor infiltration by regulatory (Treg) T cells. Methods: The infiltration of CD3+, CD8+, CD4+, CD8+CCR-7+ (Tccr7) and CD4+FoxP3+- (Treg) -T lymphocytes was investigated by immunohistochemistry in the tumor samples at diagnosis of 76 advanced colorectal cancer patients. We searched for a possible correlation of Tccr7 tumor infiltration score with either Treg tumor infiltration extent and patient outcome. Results: High Tccr7 tumor infiltration score was highly predictive of a prolonged overall survival (OS) [high v.s. low score: 41.3 months (95%CI: 30.7-51.9) v.s. 26 (95% CI: 20.6-33.2) months, hazard ratio (HR) = 0.52 (95 %CI: 0.27-0.99); P=0.048)] with a trend to a better treatment related survival and time to progression to first-line chemotherapy. No correlation by regression curve analysis could be demonstrated between Tccr7 and Treg tumor infiltration scores; however, a cluster of patients with a concomitant high infiltration by both T cell populations was identified, who presented a very positive outcome [double high v.s. double low tumor infiltration score: OS= 44 months (95%CI: 27.5-60.4) v.s. 26.1 (95%CI:18.3-34); HR= 0.41 (95%CI: 0.20- 0.93); P=0.03). Conclusions: High Tccr7 tumor infiltration at diagnosis represents a favorable prognostic factor for advanced colorectal cancer patients. A critical role of local immune-response for the long term survival of colorectal cancer patients is suggested.
Automated variable aortic control versus complete aortic occlusion in a swine model of hemorrhage (2017)

Permissive regional hypoperfusion with variable aortic control minimizes the adverse effects of distal ischemia, optimizes proximal pressure to the brain and heart, and prevents exsanguination in this model of lethal hemorrhage. These findings provide foundational knowledge for the continued development of this novel paradigm and inform next-generation endovascular designs.
Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition (2012)

Recent studies reveal that long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in cancer biology, and lncRNA MALAT-1 expression is upregulated in some tumors. However, the contributions of MALAT-1 to bladder cancer metastasis remain largely unknown. In the present study we evaluated MALAT-1 expression in bladder cancer tissues by real-time PCR, and defined its biological functions. We verified that MALAT-1 levels were upregulated in bladder cancer tissues compared with adjacent normal tissues, and MALAT-1 expression was remarkably increased in primary tumors that subsequently metastasized, when compared to those primary tumors that did not metastasize. SiRNA-mediated MALAT-1 silencing impaired in vitro bladder cancer cell migration. Downregulation of MALAT-1 resulted in a decrease of the epithelial-mesenchymal transition (EMT)-associated ZEB1, ZEB2 and Slug levels, and an increase of E-cadherin levels. We further demonstrated that MALAT-1 promoted EMT by activating Wnt signaling in vitro. These data suggest an important role for MALAT-1 in regulating metastasis of bladder cancer and the potential application of MALAT-1 in bladder cancer therapy.
Neuroprotective activities of icariin in rodent models of Alzheimer’s disease: a systematic review and meta-analysis (2021)

Yu-Xuan Kan, Cheng-Fu Su, Zhou Zhu, Jia Liu, Xin-Jie Guan, Ashok Iyaswamy, King-Ho Cheung, Yuan Zhang, Ju-Xian Song, Min Li