gebhart/patrepeval huggingface dataset:
Decision Factors on Mycophenolic Acid Dose after Renal Transplantation (2009)

Soo Jin Kim, M.D., Myoung Soo Kim, M.D., Duck Jong Han, M.D., Chul Woo Yang, M.D., Samuel Lee, M.D., Ik-Jin Yun, M.D., Byoung-Soo Cho, M.D., Tae Won Lee, M.D., Hark Rim, M.D., Myung-Jae Kim, M.D., Dong-Cheol Han, M.D., Gyu Tae Shin, M.D., Chang-Kwon Oh, M.D., Jun-Young Do, M.D., Sang Youb Han, M.D., Soo Jin Na Choi, M.D. and Ki Ryang Na, M.D.. J Korean Soc Transplant 2009;23:135-40. https://doi.org/10.4285/jkstn.2009.23.2.135
Science and Technology with Optical Frequency Combs (2011)

The basic operation, implementation and control of femtosecond laser optical frequency combs will be presented. The application of frequency combs in various scientific and technological fields will be described. 150-word Biography: Scott Diddams received the B.A. in Physics from Bethel College, St. Paul, MN in 1989 and the Ph.D. degree in Optical Science from the University of New Mexico, Albuquerque in 1996. From 1996 through 2000, he did postdoctroral work at JILA, University of Colorado. In 1998 Dr. Diddams was awarded a National Research Council fellowship to work with Dr. John Hall (also at JILA) on the development of optical combs for frequency metrology. The techniques developed at that time have had a significant impact on the fields of ultrafast optics and optical frequency metrology. Since 2000, Dr. Diddams has been a staff member and project leader at the National Institute of Standards and Technology (NIST) where he and his coworkers have continued the development of optical frequency combs for optical clocks, waveform generation, low-noise microwave synthesis, spectroscopy and other applications. Dr. Diddams was a co-recipient of a Department of Commerce gold medal for "revolutionizing the way frequency is measured" and was additionally the recipient of the Presidential Early Career Award in Science and Engineering (PECASE) for his work on optical frequency combs. He is a Fellow of the OSA and APS and a member of IEEE. Article not available.
Detection of Minerals Through the Processing of Satellite Images (2018)

Currently, the city of Cerro de Pasco is officially in emergency due to the high level of contamination of its natural resources caused by the open pit mine that exists in the middle of the city and something more dangerous, air pollution by waste toxic substances that pile up inside and around the city. In this sense, this research proposes and develops the detection of the percentage of lead sulfide and zinc oxide, scattered in the city, using the digital processing of multispectral satellite images. As a result of this mineral detection, it is obtained that more than a quarter of the area of the city, it contains minerals scattered in urban areas.
A case of Warthin's tumor of right parotid gland. (1985)

Warthin's tumor is a distinctive tumor of salivary gland.A 39 year-old man visited our clinic, complaining of swelling on the lower part of the right parotid gland, which had been noticed for abot 2 years and gradually increased in sizethereafter.Clinical examination revealed a thumb's head sized tumor. That was firm, elastic, painless, and clearly demarcated from the surrounding tissues.Sialographic examination revealed no change of the parotid gland.Under local anesthesia, tumor was surgically removed. It was oval and well encapsulated. The cut surface of tumor was cystic, and the contents were mucous.Pathological diagnosis was Warthin's tumor.The patient has no complaint.
[Inhibition of serotonin-induced platelet aggregation by endothelins]. (1992)

Endothelins are a family of three peptides that act as local hormones in all mammalian species. They were found to inhibit rabbit and dog platelet aggregation in vivo, whereas no effect was observed in vitro. In order to investigate the possible interaction between endothelins and human platelet serotonergic receptors, their effect on the platelet aggregation, induced by serotonin, was studied. Endothelin-1, -2 and -3 had a dual action for platelet aggregation induced by serotonin. When added simultaneously to serotonin endothelins aggregatory response to this amine was potentiated. On the contrary, preincubation of platelet suspension with endothelins resulted in a concentration-dependent inhibition of serotonin-promoted platelet response. Moreover, endothelin-1 inhibited serotonergic amplification of epinephrine-induced aggregation of platelets. It is proposed that endothelins bind to the platelet membrane and interact with serotonergic receptors and/or G proteins. The diverse effect of eodothelins on serotonin-induced aggregation of platelets may be due to stimulation of protein kinase C.
Continuum and lattice heat currents for oscillator chains (2009)

We show that two commonly used definitions for the heat current give different results-through the Kubo formula-for the heat conductivity of oscillator chains. The difference exists for finite chains, and is expected to be important more generally for small structures. For a chain of N particles that are tethered at the ends, the ratio of the heat conductivities calculated with the two currents differs from unity by O(1/N). For a chain held at constant pressure, the difference from unity decays more slowly, and is consistent with O(1/Neta) with 1>eta>0.5.
A yield improvement technique for IC layout using local design rules (1992)

The concept of local design rules is introduced. These are integrated circuit (IC) layout rules that define the optimum feature size and spacing in relation to the surrounding geometry and are used to increase the yield of ICs. The impact of these rules on the performance and reliability of ICs is discussed. Algorithms that enable the automatic application of track displacement, track width, and contact size local design rules to IC layout are presented. Simulation results are provided for some layout examples.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
PORTABLE ULTRASONIC GUIDED WAVE INSPECTION WITH MACRO FIBER COMPOSITE ACTUATORS (2010)

The development of portable ultrasonic guided wave transducer arrays that utilize Macro Fiber Composite actuators (MFCs) is described. Portable inspection equipment can make use of ultrasonic guided waves to rapidly screen large areas of many types of engineering structures for defects. The defect finding performance combined with the difficulty of application determines how much the engineering industry makes use of this non‐destructive, non‐disruptive technology. The developments with MFCs have the potential to make considerable improvements in both these aspects. MFCs are highly efficient because they use interdigital electrodes to facilitate the extensional, d33 displacement mode. Their fiber composite design allows them to be thin, lightweight, flexible and durable. The flexibility affords them conformance with curved surfaces, which can facilitate good mechanical coupling. The suitability of a given transducer for Long Range Ultrasonic Testing is governed by the nature and amplitude of the displacement that it excites/senses in the contact area of the target structure. This nature is explored for MFCs through directional sensitivity analysis and empirical testing. Housing methods that facilitate non‐permanent coupling techniques are discussed. Finally, arrangements of arrays of MFCs for the guided wave inspection of plates and pipes are considered and some broad design criteria are given.
Nanoporous alumina microtubes for metamaterial and plasmonic applications (2018)

Double anodization of aluminium microwires in an acid bath yields cylindrical nanoporous alumina with nonbranching radially emanating pores. The obtained nanoporous alumina is a cylindrically anisotropic as well as a radially inhomogeneous optical medium. Detailed structural characterization reveals that the nanopore diameter varies linearly with the radius of the aluminium microwire along the radial direction. Microcracks form on the alumina shell during the anodization when sufficient thickness is formed due to volume expansion and stress accumulation. The formation of the microcracks can be monitored by the anodization current which shows sudden jumps when the cracks are formed. After removing the remaining aluminium at the core of the anodised wire the anisotropic and inhomogeneous alumina microtube is obtained. Such nanoporous alumina microtubes form unique optical waveguides and are useful for microscale heat transfer applications.
Preventing smoking relapse in patients with cancer: A randomized controlled trial (2020)

A smoking relapse prevention intervention did not reduce relapse rates overall, but did appear to have benefited those participants who had the social support of a partner. Future work is needed to extend this effect to the larger population of patients.
The treatment of localized Ewing's sarcoma: The experience at the istituto ortopedico rizzoli in 163 cases treated with and without adjuvant chemotherapy (1982)

Eighty consecutive patients with localized Ewing's tumor treated with adjuvant chemotherapy for two years plus local tumor control were retrospectively reviewed. Adjuvant chemotherapy protocol was constant for all patients, but local treatment consisted of amputation, resection (complete or incomplete) plus radiotherapy, or radiotherapy alone. The follow-up ranged from 21--101 months (mean = 50 months). The mortality rate and incidence of metastasis were significantly lower than in a comparable group of 83 patients previously treated by radiotherapy, or surgery plus radiotherapy but without chemotherapy. The percentage of local recurrence was not significantly different between the two groups. Of the patients treated with adjuvant chemotherapy, the percentage of local recurrence and metastases was much lower when the primary lesion was located in the extremities and when this lesion was treated by conservative surgery followed by irradiation. This was also true when the resection was not complete. Little discrepancy in functional results was observed using either resection plus radiotherapy or radiotherapy alone. The above data suggest that in treating Ewing's sarcoma, conservative surgery, even incomplete, can play an important role when associated with radiotherapy and adjuvant chemotherapy.
Nanomaterials and biomaterials in electrochemical arrays for protein detection (2013)

Nanomaterials and biomaterials are important components of new electrochemical arrays designed for sensitive detection of proteins in biological fluids. Such multiplexed protein arrays are predicted to have an important future in personalized medical diagnostics, especially for cancer and heart disease. Sandwich immunoassays for proteins benefit greatly in sensitivity from the use of nanostructured sensor surfaces and multilabeled detection strategies involving nano- or microparticles. In these assays, capture agents such as antibodies or aptamers are attached to sensor surfaces in the array. Target proteins with large binding constants for the affinity agents are captured from liquid samples with high efficiency, either on the sensors or on magnetic bioconjugate particles decorated with many copies of labels and antibodies. After target proteins are captured on the sensor surfaces, the labels are detected by electrochemical techniques. This feature article begins with an overview of the recent history of nanoparticles in electrochemical protein sensors, then moves on to specific examples from our own laboratories. We discuss fabrication of nanostructured sensors and arrays with the aim of multiplexed detection as well as reusability. Following this, we describe systems that integrate particle-based protein sensing with microfluidics for multiplexed protein detection. We end with predictions on the diagnostic future of protein detection.
Hematite iron oxide nanorod patterning inside COK-12 mesochannels as an efficient visible light photocatalyst (2015)

Three-dimensional visualization of hematite iron oxide nanorod patterning inside hexagonally ordered mesochannels of COK-12 by electron tomography.
Covalent Assembled Osmium-Chromophore-Based Monolayers:  Chemically Induced Modulation of Optical Properties in the Visible Region (2006)

Chemical addressing of the metal oxidation state of an osmium-based chromophore monolayer results in modulation of the optical properties in the entire visible region (400−750 nm). The monolayers are thermally robust, and 25 Os2+/Os3+ redox cycles are demonstrated.
ChemInform Abstract: DESIGN AND SYNTHESIS OF POLY(SUBSTITUTED) TETRATHIAFULVALENE PRECURSORS (1977)

Abstract Die Herstellung von Vorstufen zur Synthese von Tetrathiafulvalen‐Derivaten wird gemäß dem Formelschema untersucht, indem aus (I) mit Dithiocarbaminaten (II) die Verbindungen (III) und (IV) hergestellt werden.
The Combination of MK-2206 and WZB117 Exerts a Synergistic Cytotoxic Effect Against Breast Cancer Cells (2019)

Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death in women. Hormone receptor-positive breast cancer is usually subjected to hormone therapy, while triple-negative breast cancer is more formidable and poses a therapeutic challenge. Glucose transporters are potential targets for the development of anticancer drugs. In search of anticancer agents whose effect could be enhanced by a GLUT1 inhibitor WZB117, we found that MK-2206, a potent allosteric Akt inhibitor, when combined with WZB117, showed a synergistic effect on growth inhibition and apoptosis induction in breast cancer cells, including ER(+) MCF-7 cells and triple-negative MDA-MB-231 cells. The combination index values at 50% growth inhibition were 0.45 and 0.21, respectively. Mechanism studies revealed that MK-2206 and WZB117 exert a synergistic cytotoxic effect in both MCF-7 and MDA-MB-231 breast cancer cells by inhibiting Akt phosphorylation and inducing DNA damage. The combination may also compromise DNA damage repair and ultimately lead to apoptosis. Our findings suggest that the combination of Akt inhibitors and GLUT1 inhibitors could be a novel strategy to combat breast cancer.
Supplementary Data 6 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death (2023)

&lt;p&gt;p53 ChIPseq peaks from osteoblasts derived from normal and LFS individuals&lt;/p&gt;
Determination of multiple antibiotics in leafy vegetables using QuEChERS–UHPLC–MS/MS (2017)

A modified quick, easy, cheap, effective, rugged, and safe method was established for simultaneous extraction and cleanup of multiple antibiotics in leafy vegetables, and ultra-high performance liquid chromatography with tandem mass spectrometry was used for analysis. Antibiotics in leafy vegetables were extracted with citric acid/sodium citrate in mixed solvents consisting of acetonitrile/methanol (85:15, v/v) from 10 g of vegetables. Octadecylsilyl and graphitized carbon black were used as dispersant adsorbents. This method was able to effectively extract all of the target antibiotics from leafy vegetables. The average recoveries of 20 antibiotics ranged from 57 to 91%. The limits of detection were 0.33-2.92 μg/kg. The developed method subsequently demonstrated its selectivity, sensitivity, and reliability for detecting multiple antibiotics in 15 samples. Antibiotic residues in vegetables have attracted great concern with respect to human health. It is recommended that standards should be established for antibiotic residues in vegetables to ensure food safety.
A 1.2Gb/s/pin wireless superconnect based on inductive inter-chip signaling (IIS) (2004)

A wireless bus for stacked chips is designed with the interface using inductive coupling with metal spiral inductors. Transceiver circuits non-return-to-zero signaling are developed. Test chips stacked at a distance of 300/spl mu/m communicate at data rates of up to 1.2Gb/s/pin. Fabricated in 0.35/spl mu/m CMOS technology, TX and RX dissipation are 43 and 2.5mW, respectively.
Preparation and Properties of Single Crystals of Hydrogen Bis(Phthalocyaninato) Neodymium(III) (1985)

Abstract Single crystals of hydrogen bis(phthalo-cyaninato)neodymium(III) have been synthesized by electrochemical means. The crystals are semiconductors and follow Curie-Weiss behavior.
Effects of Intragastric Balloon on Weight Loss, Physical Activity, Plasma Leptin and Ghrelin in Obese Patients, with Long-Term Follow-Up (2013)

AIM: Intra-gastric balloon (IGB) represents, in the short-term, an alternative for obese patients non responding to diet and reluctant to surgery. Long-term effects of IGB have been rarely described. METHODS: BioEnterics IGB were placed in consecutive patients with Body Mass Index (BMI) higher than 30 kg/m2 with at least one co-morbidity, or BMI higher than 35 kg/m2. Body weight and physical activity (actimetry) were assessed before IGB insertion and just after removal. Efficacy was assessed at balloon removal (6 months), at 12 months and later on. Patients with excess weight loss (EWL) of more than 30 % were considered as responders. RESULTS: Sixty-seven patients (59 women, 88%) had a balloon inserted then removed at 6 months. Mean age±SD was 38.9±9.7 years, mean BMI 36.6±3.3 kg/m2. At balloon removal, BMI dropped to 32.2±4.0 kg/m2 (p=0.0001); 35/67 patients (52%) had EWL >30%. Energy expenditure (METS) did not change. Plasma C-peptide and leptin decreased at 6 months (p=0.001). The ghrelin/leptin ratio increased (p=0.007). Twenty-nine patients (43%) had a median follow-up of 53 months. Nine of these patients (31%) were still EWL responders at last visit. These long-term responders (possible selection bias) had a smaller baseline waist circumference (<110 cm) and lower plasma C-peptide levels. CONCLUSION: The short-term efficacy of IGBs persisted in one third of patients after long-term follow-up, especially in those with smaller baseline waist circumference and lower plasma C-peptide levels.
ChemInform Abstract: 6α‐FORMYLPENICILLINS AND DERIVATIVES (1985)

Abstract Die bekannten Hydroxymethyl‐penicilline (Ia)‐(le) werden zu den Formylverbindungen (II) nach unterschiedlichen, im einzelnen aufgeführten Verfahren oxidiert und dann durch eine katalytische Debenzylierung und Reaktion mit Natriumcarboxylaten in die Salze (IIIa)‐(IIId) übergeführt.
Critical Micelle Concentrations of Sodium Dodecyl Sulfate and Cetyltrimethylammonium Bromide Mixtures in Binary Mixtures of Various Salts at Different Temperatures and Compositions (2019)

By conductivity method were examined the aggregation behavior of cationic amphiphile–cetyltrimethylammonium bromide (CTAB) and anionic amphiphile–sodium dodecyl sulfate (SDS) mixtures in binary mixtures of various salts. The values of critical micelle concentration (cmc) of SDS–CTAB mixtures lie between the cmc values of the pure amphiphiles. With temperature increasing the cmc values decrease first and then enhance with further rise of the temperature. The observed cmc of the SDS–CTAB mixed systems in attendance of binary mixture of salts was obviously less as compared to aqueous solution. The degree of counterion dissociation along with cmc value was utilized to evaluate different thermodynamic parameters. The values of interaction parameters and excess free energy were found to be negative in all cases. All results obtained reveal the strong interaction between the studied amphiphiles.
Dispersion by chemical reaction of Rocky Mountain Arsenal Basin F waste soils (1997)

Many military installations have soil contamination problems that range from heavy metals to petroleum products. Rocky Mountain Arsenal (RMA) Basin F contains high concentrations of salts, heavy metals, ammonia, urea, and organics. The Dispersion by Chemical Reaction (DCR) process leads to a reduction in the mobility of the organic and inorganic constituents by first removing volatile constituents via steam stripping and volatilization, then trapping the nonvolatile contaminants in a nonmobile phase (microencapsulation), and finally compacting the treated material into large soil bodies (macroencapsulation). This report summarizes the results of the DCR testing of soil-amended Basin F sludge from RMA. The primary focus of this study is on pesticide leachability. The DCR process used to treat the Basin F waste soil produced a dry, homogeneous, soil-like material with desirable physical properties that on compaction achieved the following remediation goals: reduction of all leachable volatiles to nondetectable levels, confinement of all metals to below RCRA TCLP levels, and a decrease in pesticide leachability to levels approaching RCRA standards. For example, endrin TCLP concentration was reduced from 74 microgram/L to 20-28 microgram/L (regulatory limit = 20 ug/L). In several cases, reductions in pesticide leachability could be attributed to simple dilution with the calciummore » oxide (CaO) reagent. However in other cases, microencapsulation and/or macroencapsulation also played a role in reducing pesticide leachability. Additional work is necessary to optimize the amounts of lime-milk, hydrophobic CaO, and benign oil used in the processing of RMA Basin F waste soils. Ideally, the optimum design should achieve the regulatory and client goals, while minimizing materials handling, energy, and reagent inputs.« less
The current spin on manganites (2007)

The manganites are pseudo-cubic oxides of manganese that show extremes of functional behavior. Diverse magnetic and electronic phases coexist on a wide range of length scales even within single crystals. This coexistence demonstrates a complexity that inspires ever deeper study. Yet even the basic nature of the coexisting phases remains controversial. Can the ferromagnetic metallic phase provide fully spin-polarized electrons for spin electronics? Does the superlattice in the highly insulating phase represent charge order? Here we highlight recent results that demonstrate a coexistence of opinions about a field in rude health.
Effects of dietary interventions on DNA methylation in adult humans: systematic review and meta-analysis (2018)

DNA methylation is a key component of the epigenetic machinery that is responsible for regulating gene expression and, therefore, cell function. Patterns of DNA methylation change during development and ageing, differ between cell types, are altered in multiple diseases and can be modulated by dietary factors. However, evidence about the effects of dietary factors on DNA methylation patterns in humans is fragmentary. This study was initiated to collate evidence for causal links between dietary factors and changes in DNA methylation patterns. We carried out a systematic review of dietary intervention studies in adult humans using Medline, EMBASE and Scopus. Out of 22 149 screened titles, sixty intervention studies were included, of which 65% were randomised (n 39). Most studies (53%) reported data from blood analyses, whereas 27% studied DNA methylation in colorectal mucosal biopsies. Folic acid was the most common intervention agent (33%). There was great heterogeneity in the methods used for assessing DNA methylation and in the genomic loci investigated. Meta-analysis of the effect of folic acid on global DNA methylation revealed strong evidence that supplementation caused hypermethylation in colorectal mucosa (P=0·009). Meta-regression analysis showed that the dose of supplementary folic acid was the only identified factor (P<0·001) showing a positive relationship. In summary, there is limited evidence from intervention studies of effects of dietary factors, other than folic acid, on DNA methylation patterns in humans. In addition, the application of multiple different assays and investigations of different genomic loci makes it difficult to compare, or to combine, data across studies.