gebhart/patrepeval huggingface dataset:
Results of the First Phase I Clinical Trial of the Novel Ii-Key Hybrid Preventive HER-2/neuPeptide (AE37) Vaccine (2008)

The hybrid AE37 vaccine seems safe and well tolerated with minimal toxicity if properly dosed. AE37 is capable of eliciting HER-2/neu-specific immune responses, even without the use of an adjuvant. This trial represents the first human experience with the Ii-Key modification, and to our knowledge, AE37 is the first peptide vaccine to show potency in the absence of an immunoadjuvant.
Transport theory for light propagation in biological tissue (2004)

We study light propagation in biological tissue using the radiative transport equation. The Green's function is the fundamental solution to the radiative transport equation from which all other solutions can be computed. We compute the Green's function as an expansion in plane-wave modes. We calculate these plane-wave modes numerically using the discrete-ordinate method. When scattering is sharply peaked, calculating the plane-wave modes for the transport equation is difficult. For that case we replace it with the Fokker-Planck equation since the latter gives a good approximation to the transport equation and requires less work to solve. We calculate the plane-wave modes for the Fokker-Planck equation numerically using a finite-difference approximation. The method of computing the Green's function for it is the same as for the transport equation. We demonstrate the use of the Green's function for the transport and Fokker-Planck equations by computing the point-spread function in a half-space composed of a uniform scattering and absorbing medium.
The dysfunctional innate immune response triggered by Toll-like receptor activation is restored by TLR7/TLR8 and TLR9 ligands in cutaneous lichen planus (2014)

Background Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. Toll-like receptors (TLRs) bind numerous exogenous and endogenous antigens by recognizing conserved pathogen-associated molecular patterns (PAMPs) and have the ability to induce the production of proinflammatory cytokines. Therefore, alterations in innate immunity could explain the inflammation and T-cell autoreactivity leading to the development of LP disease. Objectives To evaluate how the host innate immune response to PAMPs is affected by cutaneous LP, primarily by using TLR agonists to induce proinflammatory cytokine secretion from peripheral blood mononuclear cells (PBMCs). Methods PBMCs from patients with LP and healthy control (HC) individuals were stimulated with agonists of TLR2/TLR1 (pam3csk4), TLR3 [poly(I:C)-RIG], TLR4 (lipopolysaccharide), TLR5 (flagellin), TLR7 (imiquimod), TLR7/TLR8 (CL097) and TLR9 (CpG). Cytokines from culture supernatants (n = 10–12) and serum chemokines and cytokines (n = 22–24) were measured using flow cytometry. Results Activation through the TLR2, TLR4 and TLR5 pathways induced increased tumour necrosis factor (TNF)-α secretion by PBMCs from individuals with LP compared with the HC group. In contrast, activation through TLR3 and TLR7 was impaired in the LP group, leading to decreased TNF-α secretion. Moreover, intracellular TLR activation resulted in reduced interleukin (IL)-1β and IL-6 secretion. Notably, individuals with LP became responders on stimulation with TLR7/TLR8 and TLR9 agonists; responses were measured as increases in interferon (IFN)-α production. Detectable TNF-α and high CXCL9 and CXCL10 serum levels were observed in patients with LP, suggesting their potential use as markers of the inflammatory status in LP. Conclusions These findings point to a defect in the TLR signalling pathways in cutaneous LP. Agonists of TLR7/TLR8 or TLR9 overcame impaired IFN-α secretion in LP, strategically acting as adjuvants to improve the type I response.
Polarized quantum dot emission in electrohydrodynamic jet printed photonic crystals (2015)

Tailored optical output, such as color purity and efficient optical intensity, are critical considerations for displays, particularly in mobile applications. To this end, we demonstrate a replica molded photonic crystal structure with embedded quantum dots. Electrohydrodynamic jet printing is used to control the position of the quantum dots within the device structure. This results in significantly less waste of the quantum dot material than application through drop-casting or spin coating. In addition, the targeted placement of the quantum dots minimizes any emission outside of the resonant enhancement field, which enables an 8× output enhancement and highly polarized emission from the photonic crystal structure.
Metal oxide and hydroxide nanoarrays: Hydrothermal synthesis and applications as supercapacitors and nanocatalysts (2013)

The development of nanotechnology in recent decades has brought new opportunities in the exploration of new materials for solving the issues of fossil fuel consumption and environment pollution. Materials with nano-array architecture are emerging as the key due to their structure advantages, which offer the possibility to fabricate high-performance electrochemical electrodes and catalysts for both energy storage and efficient use of energy. The main challenges in this field remain as rational structure design and corresponding controllable synthesis. This article reviews recent progress in our laboratory related to the hydrothermal synthesis of metal oxide and hydroxide nanoarrays, whose structures are designed aiming to the application on supercapacitors and catalysts. The strategies for developing advanced materials of metal oxide and hydroxide nanoarrays, including NiO, Ni(OH)2, Co3O4, Co3O4@Ni–Co–O, cobalt carbonate hydroxide array, and mixed metal oxide arrays like Co3−xFexO4 and ZnxCo3−xO4, are discussed. The different kinds of structure designs such as 1D nanorod, 2D nanowall and hierarchical arrays were involved to meet the needs of the high performance materials. Finally, the future trends and perspectives in the development of advanced nanoarrays materials are highlighted.
Challenges for social work education in China: findings from three metropolises (2020)

Social work education was reintroduced into China in 1988 by the Communist Party of China. Since then, many research studies have been initiated both in Chinese and English aimed at understanding the development of social work education and practice in Mainland China. However, a growing body of literature has not focused much on the students’ perspective and the challenges they face in social work education in contemporary China. In order to contribute to addressing this gap, the present study reports on qualitative interviews with a group of social work postgraduate (n = 33) students from five schools of social work covering Shandong, Shanghai and Beijing provinces in the country. The study finds that there are four major challenges for social work education in China: (i) the use of Western concepts in the Chinese context; (ii) a journey from the unknown to the known; (iii) first-generation learners; and (iv) the lack of professional identity.
Effects of Soft-diet Feeding on BDNF Expression in Hippocampus of Mice (2008)

Our previous study showed that mice fed a soft diet after weaning had reduced synaptic connections in the hippocampal formation and impaired spatial learning ability after 3 months of age. We hypothesized that soft-diet feeding during development reduced levels of brain-derived neurotrophic factor (BDNF) protein in the hippocampus, resulting in lower synaptic densities in this region. Male pups of C57BL/6 mice were fed either a solid (hard-diet group) or powdered diet (soft-diet group), starting at weaning. Expression of BDNF protein in the hippocampus and cerebral cortex was evaluated quantitatively with enzyme-linked immunosorbent assay (ELISA) at 1, 3 and 6 months of age. Reduction in BDNF protein levels due to soft diet was detected markedly in the hippocampus of 3- and 6-month-old mice. On the other hand, a soft diet showed no significant effect on BDNF content in the cerebral cortex throughout the ages investigated. Immunohistochemistry of hippocampal formation in 3-month-old mice revealed that intensities of BDNF immunoreactivity in the dentate gyrus granule cell layer and CA1 and CA3 pyramidal cell layers appeared diminished in mice fed the soft diet compared with mice fed the hard diet. These results indicate that insufficient mastication activity during development reduces BDNF protein levels in the hippocampus and influences synaptic plasticity in this region.
AlGaN/AlN/GaN high-power microwave HEMT (2001)

In this letter, a novel heterojunction AlGaN/AlN/GaN high-electron mobility transistor (HEMT) is discussed. Contrary to normal HEMTs, the insertion of the very thin AlN interfacial layer (/spl sim/1 nm) maintains high mobility at high sheet charge densities by increasing the effective /spl Delta/E/sub C/ and decreasing alloy scattering. Devices based on this structure exhibited good DC and RF performance. A high peak current 1 A/mm at V/sub GS/=2 V was obtained and an output power density of 8.4 W/mm with a power added efficiency of 28% at 8 GHz was achieved.
Antitumor activity of fibroblast growth factor receptor 3–specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis (2008)

Human single-chain Fv directed against fibroblast growth factor receptor 3 (FGFR3) have been shown to block proliferation of RT112 bladder carcinoma cells in vitro. Here, we examined the ability of the recombinant gelonin toxin (rGel) to enhance this inhibitory effect in vitro and in vivo on the bladder cancer cell line RT112 and the corresponding xenografts. Immunotoxins were genetically engineered by fusing FGFR3-specific Fv fragments (3C) to the NH(2) terminus of rGel and expressed as a soluble protein in Escherichia coli. The 3C/rGel fusion construct showed an IC(50) of 200 nmol/L against log-phase RT112 cells compared with 1,500 nmol/L for free rGel. Immunofluorescence studies showed that the 3C/rGel construct internalized rapidly into the cytoplasm of RT112 cells within 1 h of exposure. The mechanism of immunotoxin-induced cell death was found to be mediated by apoptosis. RT112 tumor xenografts in severe combined immunodeficient mice treated with 50 mg/kg 3C/rGel exhibited considerable growth delay relative to control tumors and a significant reduction of 55% to 70% in mean tumor size. Immunohistochemical analysis showed that tumors from mice treated with 3C/rGel displayed considerable apoptotic damage compared with control groups. Subcellular location of FGFR3 in immunotoxin-treated tumors indicated a translocation of FGFR3 to the nuclear membrane in contrast to tumors from saline-treated controls. These results show that FGFR3-driven immunotoxins may be an effective therapeutic agent against human bladder and other tumor types overexpressing FGFR3.
Perceptual user interfaces using vision-based eye tracking (2003)

We present a multi-camera vision-based eye tracking method to robustly locate and track user's eyes as they interact with an application. We propose enhancements to various vision-based eye-tracking approaches, which include (a) the use of multiple cameras to estimate head pose and increase coverage of the sensors and (b) the use of probabilistic measures incorporating Fisher's linear discriminant to robustly track the eyes under varying lighting conditions in real-time. We present experiments and quantitative results to demonstrate the robustness of our eye tracking in two application prototypes.
Cytolytic mechanisms of intraepithelial lymphocytes in coeliac disease (CoD) (2000)

The effector arm of the mucosal immune system comprises lymphocytes scattered at intraepithelial and lamina propria levels. Intraepithelial lymphocytes (IEL) are a large population of oligoclonal resting cells which exhibit phenotypic and functional characteristics of cytolytic T cells when activated. Several mechanisms have been demonstrated to account for their cytotoxicity. Among them, one is mediated by perforin and granzyme molecules, another is mediated by Fas ligand (FasL) which delivers apoptotic signals through Fas receptor on target cells. There is good evidence that a flat intestinal mucosa may be produced by activated T cells. The aim of our study was to evaluate FasL and perforin expression by IEL, and its possible correlation with the increased enterocyte apoptosis in coeliac mucosa. Endoscopic duodenal biopsy specimens from 10 untreated coeliac patients, 10 treated coeliac patients, and 10 biopsied controls were evaluated for enterocyte apoptosis by terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine triphosphate nick end label method, for perforin expression by immunohistochemistry, and for FasL expression by immunocytochemistry. In untreated CoD there was a significant increase of percentage of both FasL+ and perforin+ IEL which positively correlated with enterocyte apoptosis in comparison with controls. All these parameters were significantly lower in treated CoD, even though they did not normalize. Our study demonstrates that in untreated CoD FasL and perforin expression by IEL is increased, and significantly correlates with the level of enterocyte apoptosis.
An Improved, Scalable, and Impurity-Free Process for Tolterodine Tartrate (2005)

Tolterodine tartrate is an anticholinergic muscle relaxant used to treat urinary frequency, urinary urgency, and incontinence in people with unstable bladders. An improved, cost-effective, and impurity-free process for tolterodine tartrate suitable for large-scale commercial production is described here by addressing various scale-up and impurity issues.
A Primary Prevention Clinical Risk Score Model for Patients With Brugada Syndrome (BRUGADA-RISK) (2020)

This multicenter study identified 4 risk factors for VA/SCD in a primary prevention BrS population. A risk score model was generated to quantify risk of VA/SCD in BrS and inform implantable cardioverter-defibrillator prescription.
Functional Pattern of Sacral Root Stimulation in Dogs I. Micturition (1982)

Prior to this study, electrostimulation of the ventral sacral roots had only limited success in evacuation of the bladder because dyssynergic sphincter contraction simultaneously increased urethral resistance. Thus, pudendal nerve blockade, pudendal neurotomy, selective peripheral neurotomy, or external sphincterotomy for reduction of sphincteric resistance seemed inevitable. To avoid those procedures we used electrical sphincter fatigue to induce effective micturition with stimulation of the ventral sacral roots. Stimuli of 200 Hz frequency rapidly fatigue the dyssynergic sphincteric response but not the desired detrusor contraction, eliminating the need of interference with the sphincteric activity.
Resiliency assessment of the power system network to cyber and physical attacks (2006)

Studies of fault tolerant of network can be modeled based on classical graph connectivity. This study is very basic yet it conveys succinct information on the degree of vulnerability of network topology in imbedded systems such as the electrical power system information and communication networks. In this paper, the degree of vulnerability of the North American Electric Reliability Council (NERC) power network to attacks is studied. The degree of vulnerability can be deemed as a measure of the resiliency of the network to attacks launched via cyber means or through physical means. New definition to calculate the resiliency is proposed. The attacks are simulated either by 'killing' a node that is, by taking a processing element out of service and or by removing links (communication channels) out of service and identifying the overall resiliency of the system. Different cases are carried out. It is anticipated that the results would provide some quantitative measures in terms of the degree of network vulnerability and the resiliency of the network to attacks.
Macrophage Diversity and Polarization in Atherosclerosis (2009)

Diversity and plasticity are hallmarks of mononuclear phagocytes, which are reflected in plaque formation and evolution. Different monocyte subsets, which differentially contribute to plaque infiltration and to atherosclerosis complications, have been identified. Similarly, depending on different environmental signals plaque-associated macrophages can express polarized pro- and antiatherogenic programs by influencing lipid metabolism, inflammatory responses, and plaque stability. Thus, a "macrophage balance" plays a major role in the pathogenesis of atherosclerotic plaques and affects evolution and complications of atherosclerosis.
Supercharging planetlab (2007)

In recent years, overlay networks have become an important vehicle for delivering Internet applications. Overlay network nodes are typically implemented using general purpose servers or clusters. We investigate the performance benefits of more integrated architectures, combining general-purpose servers with high performance Network Processor (NP) subsystems. We focus on PlanetLab as our experimental context and report on the design and evaluation of an experimental PlanetLab platform capable of much higher levels of performance than typical system configurations. To make it easier for users to port applications, the system supports a fast path/slow path application structure that facilitates the mapping of the most performance-critical parts of an application onto an NP subsystem, while allowing the more complex control and exception-handling to be implemented within the programmer-friendly environment provided by conventional servers. We report on implementations of two sample applications, an IPv4 router, and a forwarding application for the Internet Indirection Infrastructure. We demonstrate an 80x improvement in packet processing rates and comparable reductions in latency.
Reactions of alpha-nucleophiles with a model phosphate diester (2008)

Substantial rate enhancements are observed for the reactions of -effect nucleophiles with 2,4dinitrophenyl ethyl phosphate diester 4. The effect is largest (ca. 4500-fold) for the hydroperoxide anion. However, the most reactive -effect nucleophile, and thus the most reactive nucleophile towards phosphate phosphorus at pHs near to or above its pK a of 13.74, is the hydroxylamine anion NH 2 O -. The kinetic reactivities of the -effect nucleophiles follow a Brnsted correlation, with a slope nuc = 0.410.03 greater than that (0.30) observed for non-effect nucleophiles, consistent with a thermodynamic origin for the effect.
Microglia Regulate Neuroglia Remodeling in Various Ocular and Retinal Injuries (2018)

Abstract Reactive microglia and infiltrating peripheral monocytes have been implicated in many neurodegenerative diseases of the retina and central nervous system (CNS). However, their specific contribution in retinal degeneration remains unclear. We recently showed that peripheral monocytes that infiltrate the retina after ocular injury in mice become permanently engrafted into the tissue, establishing a pro-inflammatory phenotype that promotes neurodegeneration. Here, we show in mice that microglia regulate the process of neuroglia remodeling during ocular injury, and their depletion results in marked upregulation of inflammatory markers, such as Il17f , Tnfsf11 , Ccl4 , Il1a , Ccr2 , Il4 , Il5 , and Csf2 in the retina, abnormal engraftment of peripheral CCR2 + CX3CR1 + monocytes into the retina and is associated with increased retinal ganglion cell (RGC) loss, retinal nerve fiber layer thinning, and RPE65 + cell migration onto the retinal surface. Furthermore, we show that other types of ocular injuries, such as penetrating corneal trauma and ocular hypertension, also cause similar changes. However, optic nerve crush injury mediated RGC loss evokes neither peripheral monocyte response in the retina, nor RPE65 + cell migration, although peripheral CX3CR1 + and CCR2 + monocytes infiltrate the optic nerve injury site and remain present for months. Our study suggests that microglia are key regulators of peripheral monocyte infiltration and RPE migration and their depletion results in abnormal neuroglia remodeling that exacerbates neuroretinal tissue damage. This mechanism of retinal damage through neuroglia remodeling may be clinically important for the treatment of patients with ocular injuries, including surgical traumas.
The effects on anterior pituitary hormone secretion of salmon calcitonin in healthy volunteers (1991)

The reports of the effect of calcitonin on pituitary function are confusing and often refer to uncontrolled studies. We have now carried out a double-blind placebo-controlled trial of intravenous and subcutaneous salmon calcitonin on anterior pituitary function in 17 healthy volunteers. Visual analogue scores for the nausea and vomiting seen after salmon calcitonin correlated with the rise in ACTH and, secondarily, cortisol. Calcitonin had no effect on growth hormone, prolactin, thyrotrophin, luteinizing hormone or follicle stimulating hormone. It is concluded that the stimulation of ACTH secretion following a single dose of salmon calcitonin is probably the result of the stress of nausea rather than a direct effect on the pituitary.
Color-Tuned Highly Fluorescent Organic Nanowires/Nanofabrics: Easy Massive Fabrication and Molecular Structural Origin (2009)

The development of one-dimensional fluorescent nanowires (1D-NWs) and their higher-dimensional architectures such as nanowebs and nanofabrics (2D-NFs) could open a new area in nanomaterials science and nanotechnology. In particular, fluorescent pi-electronic 1D-NWs are considered promising materials for realizing innovative nanodevices together with semiconductors and metallic NWs. We earlier reported that 1-cyano-trans-1,2-bis-(3',5'-bis-trifluoromethyl-biphenyl)ethylene (CN-TFMBE), a simple but very peculiar derivative of oligo(p-phenylene vinylene)s (OPV) composed of a cyano-stilbene backbone, self-assembles easily into 1D-NWs with highly enhanced fluorescence emission in the solid state. We report herein surprising new outcomes obtained from a more detailed exploration of the self-association behavior of CN-TFMBE and its analogues. We found that CN-TFMBE self-assembled into highly fluorescent 1D-NWs and 2-D NFs very easily and massively, irrespective of whether drop casting, spin coating, or vacuum deposition was used for processing. However, we additionally found that, if the backbone cyano group or trifluoromethyl substituents were removed from CN-TFMBE, the resulting molecule did not form 1D-NWs under any conditions. Through structural analyses using mid- and wide-angle X-ray diffraction methods and multiscale computer simulation techniques, we formulated molecular structural guidelines for programming pi-electron molecules into highly fluorescent 1D-NWs and 2-D NFs. Interestingly, we demonstrated that R,G,B,Y-color tuned 1D-NWs and NFs could be easily and massively fabricated based on our guidelines. This class of highly fluorescent color-tuned organic pi-electronic nanomaterial is expected to open a new phase in applications such as nanoscale optoelectronics, sensing, and biological devices.
Microarray Analysis from A CreER-Based Random Induction Strategy for Modeling Translocation-Associated Sarcomas in Mice (2023)

Microarray Analysis from A CreER-Based Random Induction Strategy for Modeling Translocation-Associated Sarcomas in Mice