gebhart/patrepeval huggingface dataset:
SDSC-seeded scaffolds. (2015)

&lt;p&gt;Cell matrix interactions in the scaffold (Autofluorescence/green) were evaluated 4 hours after cell seeding. Cells are presented in blue (DNA: 40,6-diamidino-2-phenylindole (DAPI)) and red (F-actin: phalloidin). After 7 days a homogeneous distribution of SDSC in the scaffold could be shown (A). Cell metabolic activity in the scaffold was evaluated for different time points by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The metabolic activity remained significantly unchanged after 7 days of culture (white bars: LPS-stimulated SDSC; grey bars: unstimulated SDSC). 4 days later a significant difference in metabolic activity was found (B).&lt;/p&gt;
MicroRNA-33 (miR-33) (2015)

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Dense calcium and lesion-specific ischemia: A comparison of CCTA with fractional flow reserve (2017)

Dense calcium is not an independent predictor of ischemia, but rather a marker of aggregate LPV, which in turn, is predictive of ischemia.
Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety (2009)

We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivatives fused with thiophene moiety. Initially the acute toxicity of the compounds was assayed via the determination of their LD_{50}. The antiarrhythmic activities for the compounds were determined and all the tested compounds were found more potent than Procaine amide^{\textregistered} and Lidocaine^{\textregistered} as positive antiarrhythmic controls.
A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes (2012)

The respiratory metabolic cycle in budding yeast (Saccharomyces cerevisiae) consists of two phases that are most simply defined phenomenologically: low oxygen consumption (LOC) and high oxygen consumption (HOC). Each phase is associated with the periodic expression of thousands of genes, producing oscillating patterns of gene expression found in synchronized cultures and in single cells of slowly growing unsynchronized cultures. Systematic variation in the durations of the HOC and LOC phases can account quantitatively for well-studied transcriptional responses to growth rate differences. Here we show that a similar mechanism-transitions from the HOC phase to the LOC phase-can account for much of the common environmental stress response (ESR) and for the cross-protection by a preliminary heat stress (or slow growth rate) to subsequent lethal heat stress. Similar to the budding yeast metabolic cycle, we suggest that a metabolic cycle, coupled in a similar way to the ESR, in the distantly related fission yeast, Schizosaccharomyces pombe, and in humans can explain gene expression and respiratory patterns observed in these eukaryotes. Although metabolic cycling is associated with the G0/G1 phase of the cell division cycle of slowly growing budding yeast, transcriptional cycling was detected in the G2 phase of the division cycle in fission yeast, consistent with the idea that respiratory metabolic cycling occurs during the phases of the cell division cycle associated with mass accumulation in these divergent eukaryotes.
Fine Particle Beneficiation through Selective Agglomeration with an Emulsion Binder (2014)

A high internal phase (HIP) water-in-oil emulsion was used as the binder in the selective agglomeration of fine coal from an aqueous suspension of coal and mineral particles. Traditionally, this agglomeration is achieved by a pure oil, hydrophobic, binder. However, the high cost associated with using pure oil makes the process economically unfeasible. Therefore, the emulsion binder introduced in this work was motivated by the economic need to reduce the amount of organic liquid required in the process. The effect of the agitation time during the agglomeration process and the composition of the emulsion on its performance as a binder were investigated. The best result obtained was for a HIP emulsion made from 3 wt % aqueous NaCl and diesel oil with sorbitan monooleate as the emulsifier. This emulsion had a dispersed phase volume fraction of 0.94 and achieved a 7.5-fold reduction in the amount of organic liquid required to achieve agglomeration.
Torwards marketable efficiency solution-processed kesterite and chalcopyrite photovoltaic devices (2010)

Although CuIn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> GaxSe <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2-y</sub> S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">y</sub> (CIGS) chalcopyrite and Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ZnSn(S,Se) <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> (CZTSSe) kesterite-related films offer significant potential for low-cost high-efficiency photovoltaic (PV) devices, the complicated multi-element nature of these materials generally leads to the requirement of more complex and costly deposition processes. This talk focuses on employing the unique solvent properties of hydrazine to solution-deposit CIGS and CZTSSe films for high-performance solar cells. CIGS films are deposited by completely dissolving all elements in hydrazine, solution-depositing a molecular precursor film, and heat treating in an inert atmosphere, to yield a single-phase chalcopyrite film (no post-deposition selenization required). Trace additions of Sb improve grain structure in the resulting film and enhance device performance. Devices based on a glass/Mo/spin-coated CIGS/CdS/i-ZnO/ITO structure yield power conversion efficiencies of as high as 13.6% (AM1.5 illumination; NREL certified). Analogous CZTSSe absorber layers have been processed using a hybrid hydrazine-based slurry approach, enabling liquid-based deposition of kesterite-type films and resulting device efficiencies of as high as 9.6% (AM1.5 illumination; NREL certified)-exceeding the previous kesterite performance record by ~40%. The combination of improved efficiency, In-free absorber and solution-based processing opens opportunities for development of a low-cost and pervasive technology.
Liver-Specific Peroxisome Proliferator–Activated Receptor α Target Gene Regulation by the Angiotensin Type 1 Receptor Blocker Telmisartan (2008)

The present study identifies the ARB/PPARgamma modulator telmisartan as a partial PPARalpha agonist. As a result of its particular pharmacokinetic profile, PPARalpha activation by telmisartan seems to be restricted to the liver. Hepatic PPARalpha activation may provide an explanation for telmisartan's antidyslipidemic actions observed in recent clinical trials.
Structure Based Approach to the Design of Bicyclic‐1H‐isoindole‐1,3(2H)‐dione Based Androgen Receptor Antagonists. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Defining the instruction set architecture (2004)

It's like building a bridge. Once the main lines of the structure are right, then the details miraculously fit. The problem is the overall design.Freeman Dyson in Freeman Dyson: Mathematician, Physicist, and Writer, Interview with Donald J. Albers, The College Mathematics Journal, 25, No. 1, January 1994.
Immune response to a potyvirus with exposed amino groups available for chemical conjugation (2012)

TEV has surface amino groups that are available for chemical coupling. TEV induces both humoral and cellular responses when administered alone intraperitoneally to mice. Therefore, TEV should be evaluated as a vaccine adjuvant when chemically coupled to antigens of choice.
Nanoscale elastic modulus of single horizontal ZnO nanorod using nanoindentation experiment (2012)

We measure the elastic modulus of a single horizontal ZnO nanorod [NR] grown by a low-temperature hydrothermal chemical process on silicon substrates by performing room-temperature, direct load-controlled nanoindentation measurements. The configuration of the experiment for the single ZnO NR was achieved using a focused ion beam/scanning electron microscope dual-beam instrument. The single ZnO NR was positioned horizontally over a hole on a silicon wafer using a nanomanipulator, and both ends were bonded with platinum, defining a three-point bending configuration. The elastic modulus of the ZnO NR, extracted from the unloading curve using the well-known Oliver-Pharr method, resulted in a value of approximately 800 GPa. Also, we discuss the NR creep mechanism observed under indentation. The mechanical behavior reported in this paper will be a useful reference for the design and applications of future nanodevices.
Spintronics based random access memory: a review (2017)

This article reviews spintronics based memories, in particular, magnetic random access memory (MRAM) in a systematic manner. Debuted as a humble 4 Mb product by FreeScale in 2006, the MRAM has grown to a 256 Mb product of Everspin in 2016. During this period, MRAM has overcome several hurdles and have reached a stage, where the potential for MRAM is very promising. One of the main hurdles that the MRAM overcome between 2006 and 2016 is the way the information is written. The 4 Mb MRAM used a magnetic field based switching technology that would be almost impossible to scale below 100 nm. The 256 Mb MRAM, on the other hand uses a different writing mechanism based on Spin Transfer Torque (STT), which is scalable to very low dimensions. In addition to the difference in the writing mechanism, there has also been a major shift in the storage material. Whereas the 4 Mb MRAM used materials with in-plane magnetic anisotropy, the 256 Mb MRAM uses materials with a perpendicular magnetic anisotropy (PMA). MRAM based on PMA is also scalable to much higher densities. The paper starts with a brief history of memory technologies, followed by a brief description of the working principles of MRAM for novice. Reading information from MRAM, the technologies, materials and the physics behind reading of bits in MRAM are described in detail. As a next step, the physics and technologies involved in writing information are described. The magnetic field based writing and its limitations are described first, followed by an explanation of STT mechanism. The materials and physics behind storage of information is described next. MRAMs with in-plane magnetization, their layered material structure and the disadvantages are described first, followed by the advantages of MRAMs with perpendicular magnetization, their advantages etc. The technologies to improve writability and potential challenges and reliability issues are discussed next. Some of the future technologies that might help the industry to move beyond the conventional MRAM technology are discussed at the end of the paper, followed by a summary and an outlook.
Effectiveness of Continuous Infusion of Methylprednisolone for Prevention of Antithymocyte Globulin Infusion-Related Reactions in Preparative Regimens for Allogeneic Hematopoietic Cell Transplantation (2018)

Introduction: Horse and rabbit antithymocyte globulin (ATG) are included as part of conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) to decrease graft failure and to reduce incidence and severity of graft-versus-host disease (GVHD). Infusion-related reactions (IRR) to ATG are common and require adequate premedication. Methods: A retrospective study was conducted at a large academic FACT accredited HCT center to describe the incidence and characteristics of ATG IRR between 06/2014 and 09/2017. Each ATG dose was administered slowly with antipyretic (acetaminophen or ibuprofen), antihistamine (diphenhydramine) and corticosteroid (methylprednisolone—MP) premedication. The same medications were repeated halfway into the ATG infusion. In 2016, premedication schedule was modified. Equivalent doses of MP were given as continuous infusion (CI) simultaneous with ATG rather than as bolus administration. Results: 93 patients received ATG (31 horse ATG [ATGAM] - 62 rabbit ATG [Thymoglobulin]). IRR occurred in 52 % of patients on the first day of ATG administration. The most frequent symptoms were chills (73 %) and pyrexia (69 %), with rare instances of rash (15 %), hypotension (17 %) or hypertensive episodes (8 %). Most reactions occurred during ATG infusion (60 %), but delayed reactions were also significant (40 %). The incidence of IRR increased with higher doses of ATG. No case of anaphylaxis was reported and severe reaction prevented completion of planned ATG doses in only 1 patient. CI MP was more effective than bolus MP to prevent reactions (rate of IRR on first day of ATG 32.3 % vs 61.3 %, p-value .008, chi-square test). For the 52 patients receiving identical doses of rabbit ATG for GVHD prevention, CI MP was more effective than bolus MP (CI MP n = 21 vs bolus MP n = 31 - IRR 23.8 % vs 54.8 %, p-value .026, chi-square test). Conclusion: CI MP simultaneously with ATG appears more effective in preventing IRR than bolus administration. This strategy permits successful delivery of planned ATG dose without increasing corticosteroid dose or prolonging ATG infusion duration. (Table 1)Table 1ATG Dose and Schedule and Irr RateATGMP doseNumber of patients(IRR %)Bolus MPCI MPHorse ATG1.5 mg/kg2110 10 mg/kg over 6 hours Days -3, -2, -1(61.9)(50)Rabbit ATG2 mg/kg100 2.5 mg/kg over 8 hours Days -5,-4,-3,-2(80)Rabbit ATG1.5 mg/kg3121 Over 6 hours .5 mg/kg Day -2 2 mg/kg Days -1, +1(52.8)(23.8)Total6231(61.3)(32.3) Open table in a new tab
Strong coupling detected in the photoluminescence of J-aggregate/plasmon hybrid systems (2016)

Summary form only given. The interaction between the excitonic J-band of J-aggregate molecules and localized plasmonic resonances supported by metallic structures can be large enough to reach the regime of strong coupling, giving rise to two hybridized modes [1, 2]. The new hybrid system is often characterized in extinction measurements, where the strong coupling results in an avoided crossing of the two modes as the detuning of the plasmonic mode with respect to the excitonic transition is changed. In principle, the photoluminescence (PL) signal should also exhibit a characteristic anti-crossing signature, but, so far, it has been challenging to identify it in experiments [2, 3].
Bringing the Systems Approach to Introductory Engineering Design (2025)

Successfully addressing the challenges of the 21st century requires a shift in the way that we educate engineering students. They need to employ the Systems Approach, which entails understanding the broader systems in which their designs will be used, understanding the linkages between components, and addressing more than just the technical aspects of a design. It is imperative that we develop this mindset and skill set in our students; however, introducing the Systems Approach and its associated concepts is challenging. It is crucial that students are taught to adjust their points of view in order to see the interactions of parts, as well as to recognize “the whole” in the form of emergent system characteristics. Being conversant with this flexible view will help students understand, predict, and control the effects of their decisions and solutions more effectively, especially at the technology–society interface.
The impact of computer based simulation training on leadership development (2007)

The purpose of this study was to investigate the relationship between measures of emotional intelligence after participation in a simulation based leadership development program as applied to a student cohort at a community college. Additionally, this study was conducted to investigate significant differences in emotional intelligence subscales when compared to the categorical variables of age, race, gender, position type, number of years employed, and time. 
All 300 students in the introductory management classes in the Bachelors of Applied Science business principles classes in the Business program were invited to participate. A total of 201 questionnaires representing 103 individuals were returned, garnering a 67% initial return rate; the total number of useable surveys was 182 representing 91 individuals for a final useable return rate of 60.7%. 
An analysis of the relationship between the measures of emotional intelligence before and after participating in leadership simulation revealed statistically significant differences after participation in the leadership simulation. There was a significant increase in respondent scores in three of the four subscales after the respondents participated in the Virtual Leader simulation: (a) self-emotion appraisal (SEA), p = .031; (b) others emotion appraisal (OEA), p = .002; and (c) regulation of emotion (ROE), p = .002. The emotional intelligence construct, use of emotion (UOE), p = .061, did not demonstrate statistical significance. 
A statistical analysis of all combinations and interactions of the categorical variables (age, race, gender, years employed, and position types compared to the value labeled time) resulted with the effect time as the only statistically significant effect. The label time refers to the difference between respondent scores before and after participation in a leadership simulation. This variable demonstrated a large eta squared value of .473, which suggested a large effect size.
Evaluation of Recovery Process of Pure Magnesium at Room Temperature By Acoustic Emission (2006)

Present study was conducted in order to expand the applications of acoustic emission (AE) as a tool in evaluation of the recovery behavior of pure magnesium after deformation at room temperature. From our previous research, we confirmed that AE from magnesium and its alloys during recovery process at room temperature is a unique characteristic and AE measurement should also be a promising approach in investigating such characteristic phenomenon. In present research, magnesium with purity of 99.95% was selected as the main research objective, and the cylinder specimen was compressed with strain rate of 1.67×10-4/s and unloaded with extremely high strain rate of 0.56/s for the forthcoming AE evaluation in anelastic recovery process. The AE behavior during anelastic recovery process and parameters such as anelastic recovery strain and twin densities etc. were analyzed in detail. Pseudoelastic behavior of pure magnesium was considered to be related to the detwinning and dislocation motions by the driving force of internal stress.
The Immune Landscapes of Polypoid and Nonpolypoid Precancerous Colorectal Lesions (2016)

Little is known about the immunoediting process in precancerous lesions. We explored this aspect of benign colorectal adenomas with a descriptive analysis of the immune pathways and immune cells whose regulation is linked to the morphology and size of these lesions. Two series of polypoid and nonpolypoid colorectal adenomas were used in this study: 1) 84 samples (42 lesions, each with matched samples of normal mucosa) whose gene expression data were used to quantify the tumor morphology- and size-related dysregulation of immune pathways collected in the Molecular Signature Database, using Gene Set Enrichment Analysis; 2) 40 other lesions examined with immunohistochemistry to quantify the presence of immune cells in the stromal compartment. In the analysis of transcriptomic data, 429 immune pathways displayed significant differential regulation in neoplasms of different morphology and size. Most pathways were significantly upregulated or downregulated in polypoid lesions versus nonpolypoid lesions (regardless of size). Differential pathway regulation associated with lesion size was observed only in polypoid neoplasms. These findings were mirrored by tissue immunostaining with CD4, CD8, FOXP3, MHC-I, CD68, and CD163 antibodies: stromal immune cell counts (mainly T lymphocytes and macrophages) were significantly higher in polypoid lesions. Certain markers displayed significant size-related differences regardless of lesion morphology. Multivariate analysis of variance showed that the marker panel clearly discriminated between precancerous lesions of different morphologies and sizes. Statistical analysis of immunostained cell counts fully support the results of the transcriptomic data analysis: the density of infiltration of most immune cells in the stroma of polypoid precancerous lesions was significantly higher than that observed in nonpolypoid lesions. Large neoplasms also have more immune cells in their stroma than small lesions. Immunoediting in precancerous colorectal tumors may vary with lesion morphology and stage of development, and this variability could influence a given lesion's trajectory to cancer.
Subsurface temperature maxima in the Labrador Sea and the subpolar North Atlantic (2006)

Deep and shallow subsurface temperature maxima (Tmax) in the Labrador Sea are found to be the result of anomalous freshwater input during past decades in particular during the early 1990s. The deep Tmax is associated with a specific water mass imported into the Labrador Sea. The shallow Tmax is of local origin and created by anomalous heat input in 1999, not eroded by surface buoyancy forcing in recent years. Both are associated with stability maxima: the deep Tmax is a barrier for maximum convection depth, the shallow Tmax separates the water in a layer ventilated by overturning and a layer modified through lateral fluxes only. The shallow Tmax is exported into the subpolar gyre. A complementary shallow Tmax in the Greenland Sea suggest a concerted response of deep convection regions to anomalous freshwater input: diminished vertical mixing and dominance of lateral heat/salt fluxes underneath Tmax, shallow convection above it.
Bacterial Soft Rot, a New Disease of Pak-choi (Brassica campestris L., chinensis group) Caused by Erwinia carotovora subsp. carotovora. (1999)

[in Japanese]
Reaction of Drosophila to Different Varieties of Tomatoes (1960)

Studies were conducted at Beltsville, Maryland, to determine whether varieties of tomatoes differ in attractiveness to Drosophila melanogaster Meig. adults. San Marzano and Pennheart were the least attractive and Rutgers was the most attractive. Other varieties compared were Grothen's Globe, Pritchard, Burpee Hybrid, Pan America, Greater Baltimore, Pearson, Garden State, Marglobe, Burpee Globe, Chesapeake, Stokesdale, and John Baer.
Early detection and diagnosis of overheating problems in turbine generators by instrumental chemical analysis (1976)

Overheating problems within turbine generators if undetected can lead to catastrophic failures associated with long and costly outages. Instrumental chemical analysis methods used to detect and diagnose these hot spots are described. The Core Monitor, gas chromatograph and mass spectrometer have been applied to the analysis of the generator hydrogen coolant. By determining the concentration and type of organic thermal decomposition products in the hydrogen, the extent and possible location of the problem can be diagnosed.