gebhart/patrepeval huggingface dataset:
Trilaciclib prior to chemotherapy and atezolizumab in patients with newly diagnosed extensive‐stage small cell lung cancer: A multicentre, randomised, double‐blind, placebo‐controlled Phase II trial (2020)

Trilaciclib is an intravenous CDK4/6 inhibitor administered prior to chemotherapy to preserve haematopoietic stem and progenitor cells and immune system function from chemotherapy-induced damage (myelopreservation). The effects of administering trilaciclib prior to carboplatin, etoposide and atezolizumab (E/P/A) were evaluated in a randomised, double-blind, placebo-controlled Phase II study in patients with newly diagnosed extensive-stage small cell lung cancer (ES-SCLC) (NCT03041311). The primary endpoints were duration of severe neutropenia (SN; defined as absolute neutrophil count <0.5 × 10<sup>9</sup> cells per L) in Cycle 1 and occurrence of SN during the treatment period. Other endpoints were prespecified to assess the effects of trilaciclib on additional measures of myelopreservation, patient-reported outcomes, antitumour efficacy and safety. Fifty-two patients received trilaciclib prior to E/P/A and 53 patients received placebo. Compared to placebo, administration of trilaciclib resulted in statistically significant decreases in the mean duration of SN in Cycle 1 (0 vs 4 days; P < .0001) and occurrence of SN (1.9% vs 49.1%; P < .0001), with additional improvements in red blood cell and platelet measures and health-related quality of life (HRQoL). Trilaciclib was well tolerated, with fewer grade ≥3 adverse events compared with placebo, primarily due to less high-grade haematological toxicity. Antitumour efficacy outcomes were comparable. Administration of trilaciclib vs placebo generated more newly expanded peripheral T-cell clones (P = .019), with significantly greater expansion among patients with an antitumour response to E/P/A (P = .002). Compared with placebo, trilaciclib administered prior to E/P/A improved patients' experience of receiving treatment for ES-SCLC, as shown by reduced myelosuppression, and improved HRQoL and safety profiles.
Correction: A at Single Nucleotide Polymorphism-358 Is Required for G at -420 to Confer the Highest Plasma Resistin in the General Japanese Population (2010)

Insulin resistance is a feature of type 2 diabetes. Resistin, secreted from adipocytes, causes insulin resistance in mice. We previously reported that the G/G genotype of single nucleotide polymorphism (SNP) at 2420 (rs1862513) in the human resistin gene (RETN) increased susceptibility to type 2 diabetes by enhancing its promoter activity. Plasma resistin was highest in Japanese subjects with G/G genotype, followed by C/G, and C/C. In this study, we cross-sectionally analyzed plasma resistin and SNPs in the RETN region in 2,019 community-dwelling Japanese subjects. Plasma resistin was associated with SNP-638 (rs34861192), SNP-537 (rs34124816), SNP-420, SNP-358 (rs3219175), SNP+299 (rs3745367), and SNP+1263 (rs3745369) (P,10 213 in all cases). SNP-638, SNP -420, SNP-358, and SNP+157 were in the same linkage disequilibrium (LD) block. SNP-358 and SNP-638 were nearly in complete LD (r 2 = 0.98), and were tightly correlated with SNP-420 (r 2 = 0.50, and 0.51, respectively). The correlation between either SNP-358 (or SNP-638) or SNP-420 and plasma resistin appeared to be strong (risk alleles for high plasma resistin; A at SNP-358, r 2 = 0.5224, P = 4.94610 2324 ; G at SNP-420, r 2 = 0.2616, P = 1.71610 2133 ). In haplotypes determined by SNP-420 and SNP-358, the estimated frequencies for C-G, G-A, and G-G were 0.6700, 0.2005, and 0.1284, respectively, and C-A was rare (0.0011), suggesting that subjects with A at 2358, generally had G at 2420. This G-A haplotype conferred the highest plasma resistin (8.24 ng/ml difference/allele compared to C-G, P,0.0001). In THP-1 cells, the RETN promoter with the G-A haplotype showed the highest activity. Nuclear proteins specifically recognized one base difference at SNP-358, but not at SNP-638. Therefore, A at -358 is required for G at 2420 to confer the highest plasma resistin in the general Japanese population. In Caucasians, the association between SNP-420 and plasma resistin is not strong, and A at 2358 may not exist, suggesting that SNP-358 could explain this ethnic difference.
Optimization Models for Determining Performance Benchmarks in Wireless Sensor Networks (2009)

In this paper we propose some innovative optimization models for wireless sensor networks. The models are chosen depending on the task the network is called to execute and they focus on the optimization of some specific performance objectives. Indeed, starting from a generic configuration, the optimal solution defines a specific sensors displacement, which allows the network to achieve high performance, in terms of energy consumption and travelled distance. Controlled mobility of the nodes is used for reaching the wanted displacement. The behavior of the proposed models has been evaluated in comparison with a distributed algorithm on the basis of an extensive computational study and by considering different scenarios.
FDP control in multivariate linear models using the bootstrap (2022)

In this article we develop a method for performing post hoc inference of the False Discovery Proportion (FDP) over multiple contrasts of interest in the multivariate linear model. To do so we use the bootstrap to simulate from the distribution of the null contrasts. We combine the bootstrap with the post hoc inference bounds of Blanchard (2020) and prove that doing so provides simultaneous asymptotic control of the FDP over all subsets of hypotheses. This requires us to demonstrate consistency of the multivariate bootstrap in the linear model, which we do via the Lindeberg Central Limit Theorem, providing a simpler proof of this result than that of Eck (2018). We demonstrate, via simulations, that our approach provides simultaneous control of the FDP over all subsets and is typically more powerful than existing, state of the art, parametric methods. We illustrate our approach on functional Magnetic Resonance Imaging data from the Human Connectome project and on a transcriptomic dataset of chronic obstructive pulmonary disease.
Aloha-Based MAC Protocols with Collision Avoidance for Underwater Acoustic Networks (2007)

Unlike terrestrial networks that mainly rely on radio waves for communications, underwater networks utilize acoustic waves, which have comparatively lower loss and longer range in underwater environments. However, the use of acoustic waves pose a new research challenge in the networking area. While existing network schemes for terrestrial sensor networks are mainly designed for negligible propagation delay and high data rate, underwater acoustic communications are characterized by high propagation delay and low data rate. These terrestrial schemes, when directly applied to the underwater channel, will under-utilize its already limited capacity. We investigate how the underwater channel's throughput may be enhanced via medium access control (MAC) techniques that consider its unique characteristics. Specifically, we study the performance of Aloha-based protocols in underwater networks, and propose two enhanced schemes, namely, Aloha with collision avoidance (Aloha-CA), and Aloha with advance notification (Aloha-AN), which are capable of using the long propagation delays to their advantage. Simulation results have shown that both schemes can boost the throughput by reducing the number of collisions, and, for the case of Aloha-AN, also by significantly reducing the number of unproductive transmissions.
Monitoring angiogenesis in brain using steady‐state quantification of ΔR2 with MION infusion (2003)

An MRI method for quantification of cerebral blood volume (CBV) in time-course studies of angiogenesis is described. Angiogenesis was stimulated by acclimation to hypoxia. The change in relaxation rate, R2, which is relatively sensitive to the microvasculature, was quantified before and after infusion of a superparamagnetic vascular contrast agent (MION). The DeltaR2 was measured in serum and brain parenchyma with a multiecho sequence. In vitro and in vivo calibration curves of MION concentration vs. R2 were approximated by a linear function. CBV was 3.14 +/- 0.32% (mean +/- SE, n=13) and 6.42 +/- 0.54% (n=4) before and after acclimation. A second acclimated group was hemodiluted to control for polycythemia. CBV was not significantly different between hemodiluted and nonhemodiluted groups. In animals where NMR measurements were taken before and after acclimation, there was a 120% increase in CBV. The NMR technique was validated using quantitative morphometrics, which showed an increase of 147% in CBV with acclimation. We found a linear correlation between MRI and the morphometric results for CBV, as well as demonstrating a quantitative equivalence for relative changes in CBV. This article describes a simple, repeatable method of imaging brain microvascular volume using a plasma-based contrast agent that can be applied to longitudinal studies of angiogenesis.
Sex as a Moderator Between Parent Ratings of Executive Dysfunction and Social Difficulties in Children and Adolescents with Autism Spectrum Disorder (2022)

Girls and boys might differ in autistic symptoms and associated cognitive difficulties such as executive function (EF). We investigated sex differences in the relationship between parent rated EF and autistic symptoms in 116 children and adolescents (25 girls) aged 5-19 years with an intelligence quotient above 70 and an autism spectrum disorder (ASD) diagnosis. They were rated with the behavior rating inventory of executive function (BRIEF) and the autism diagnostic interview revised (ADI-R). We found a positive association between EF and the ADI-R domains of reciprocal social interaction (p < 0.001) and communication (p = 0.001) in girls, while these relationships were small and non-significant in boys. Our results provide a greater understanding of the sex-specific characteristics of children and adolescents with ASD.
Difference of Liver and Kidney Metabolic Profiling in Chronic Atrophic Gastritis Rats between Acupuncture and Moxibustion Treatment (2018)

Acupuncture and moxibustion proved to be very effective in chronic atrophic gastritis (CAG). According to the Chinese traditional medicine theory, chronic diseases have an influence on the function of liver and kidney. However, there is little research to demonstrate this theory. This study is aimed at assessing the <sup>1</sup>H NMR-based metabolic profiling in liver and kidney of CAG rats and comparing the difference between electroacupuncture and moxibustion treatment. Male SD rats were subjected to CAG modeling by intragastric administration of mixture of 2% sodium salicylate and 30% alcohol coupled with compulsive sporting and irregular fasting for 12 weeks and then treated by electroacupuncture or moxibustion at Liangmen (ST 21) and Zusanli (ST 36) acupoints for 2 weeks. A <sup>1</sup>H NMR analysis of liver and kidney samples along with histopathological examination and molecular biological assay was employed to assess and compare the therapeutic effects of electroacupuncture and moxibustion. CAG brought characterization of metabolomic signatures in liver and kidney of rats. Both electroacupuncture and moxibustion treatment were found to normalize the CAG-induced changes by restoring energy metabolism, neurotransmitter metabolism, antioxidation metabolism, and other metabolism, while the moxibustion treatment reversed more metabolites related to energy metabolism in liver than electroacupuncture treatment. CAG did have influence on liver and kidney of rats. Both of these treatments had good effects on CAG by reversing the CAG-induced perturbation in liver and kidney. For regulating the energy metabolism in liver, the moxibustion played more important role than electroacupuncture treatment.
Highly active iron catalysts from ferric chloride for the steam gasification of brown coal (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly active iron catalysts from ferric chloride for the steam gasification of brown coalKenji Asami and Yasuo OhtsukaCite this: Ind. Eng. Chem. Res. 1993, 32, 8, 1631–1636Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ie00020a014https://doi.org/10.1021/ie00020a014research-articleACS PublicationsRequest reuse permissionsArticle Views461Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Detection and Classification of Objects in Synthetic Aperture Radar Imagery (2006)

This is an amalgamation of a number of reports written by the author when he was contracted to DSTO through CSSIP. The reports concern the detection of faint trails, and the theory and evaluation of a number of existing and novel methods for the detection and classification of ground and maritime targets with SAR imagery. The publication of this collection allows the results to be available within defense and the wider community.
Signal Transducer and Activator of  Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis (1999)

Signal transducer and activator of transcription (STAT)5 is constitutively activated in BCR/ ABL-expressing cells, but the mechanisms and functional consequences of such activation are unknown. We show here that BCR/ABL induces phosphorylation and activation of STAT5 by a mechanism that requires the BCR/ABL Src homology (SH)2 domain and the proline-rich binding site of the SH3 domain. Upon expression in 32Dcl3 growth factor-dependent myeloid precursor cells, STAT5 activation-deficient BCR/ABL SH3+SH2 domain mutants functioned as tyrosine kinase and activated Ras, but failed to protect from apoptosis induced by withdrawal of interleukin 3 and/or serum and did not induce leukemia in severe combined immunodeficiency mice. In complementation assays, expression of a dominant-active STAT5B mutant (STAT5B-DAM), but not wild-type STAT5B (STAT5B-WT), in 32Dcl3 cells transfected with STAT5 activation-deficient BCR/ABL SH3+SH2 mutants restored protection from apoptosis, stimulated growth factor-independent cell cycle progression, and rescued the leukemogenic potential in mice. Moreover, expression of a dominant-negative STAT5B mutant (STAT5B-DNM) in 32Dcl3 cells transfected with wild-type BCR/ABL inhibited apoptosis resistance, growth factor-independent proliferation, and the leukemogenic potential of these cells. In retrovirally infected mouse bone marrow cells, expression of STAT5B-DNM inhibited BCR/ABL-dependent transformation. Moreover, STAT5B-DAM, but not STAT5B-WT, markedly enhanced the ability of STAT5 activation-defective BCR/ABL SH3+SH2 mutants to induce growth factor-independent colony formation of primary mouse bone marrow progenitor cells. However, STAT5B-DAM did not rescue the growth factor-independent colony formation of kinase-deficient K1172R BCR/ABL or the triple mutant Y177F+R522L+ Y793F BCR/ABL, both of which also fail to activate STAT5. Together, these data demonstrate that STAT5 activation by BCR/ABL is dependent on signaling from more than one domain and document the important role of STAT5-regulated pathways in BCR/ABL leukemogenesis.
Differential Fragmentation of Mobility-Selected Glycans via Ultraviolet Photodissociation and Ion Mobility-Mass Spectrometry (2017)

The alternative dissociation pathways initiated by ultraviolet photodissociation (UVPD) compared with collision-induced dissociation (CID) may provide useful diagnostic fragments for biomolecule identification, including glycans. However, underivatized glycans do not commonly demonstrate strong UV absorbance, resulting in low fragmentation yields for UVPD spectra. In contrast to UVPD experiments that leverage covalent modification of glycans, we detail the capacity of metal adduction to yield comparatively rich UVPD fragmentation patterns and enhance separation factors for an isomeric glycan set in a drift tube ion mobility system. Ion mobility and UVPD-MS spectra for two N-acetyl glycan isomers were examined, each adducted with sodium or cobalt cations, with the latter providing fragment yield gains of an order of magnitude versus sodium adducts. Furthermore, our glycan analysis incorporated front-end ion mobility separation such that the structural glycan isomers could still be identified even as a mixture and not simply composite spectra of isomeric standards. Cobalt adduction proved influential in the glycan separation by yielding an isomer resolution of 0.78 when analyzed simultaneously versus no discernable separation obtained with the sodium adducts. It is the combined enhancement of both isomeric drift time separation and isomer distinction with improved UVPD fragment ion yields that further bolster multivalent metal adduction for advancing glycan IM-MS experiments. Graphical Abstract ᅟ.
UMA ABORDAGEM PARA O MONITORAMENTO DE INDICADORES DE RESILIÊNCIA EM ORGANIZAÇÕES (2011)

Os conceitos desenvolvidos pela engenharia de resiliência permitem compreender e monitorar dinamicamente o funcionamento das organizações e, particularmente, mapear a função das atividades humanas, no sucesso ou no fracasso e nas tomadas de decisões perante situações inesperadas. A captura de informações acerca deste funcionamento proporciona aos gestores um conhecimento mais aprofundado do que está influenciando a realização das atividades das pessoas na organização, proporcionando a consciência dos fatores que interferem positivamente ou negativamente no cumprimento das metas organizacionais projetadas inicialmente. Esse monitoramento é importante porque o desempenho dos sistemas complexos é condicionado ao conhecimento que as pessoas possuem para executar as suas atividades. Dessa forma, as organizações podem antecipar-se e adaptar-se por intermédio de sinais operacionais precursores a possíveis problemas de estruturação das tarefas e atividades, segurança, qualidade, prazo, retrabalho, manutenção, etc. Esta pesquisa propõe aplicar os conceitos de engenharia de resiliência na compreensão da organização pela análise de tarefas e atividades cognitivas para o desenvolvimento de indicadores para avaliação das atividades pelos próprios agentes humanos atuantes no nível operacional, além da especificação inicial de uma ferramenta computacional para apoiar essa compreensão.
Geographic distribution ofSarcoporia polysporaandS. longitubulatasp. nov. (2015)

DNA study of Sarcoporia polyspora (= Parmastomyces transmutans ) revealed only negligible sequence differences between conifer-dwelling specimens with cartilaginous layer in the context from USA, Brazil, Europe, and Far East Asia, but a very different sequence from three resupinate and hardwood-bound collections without such a layer and with slightly narrower and pale brown spores from USA and Madeira Islands. This fungus, found also among historical USA collections of S. polyspora in the BPI herbarium, is described here as Sarcoporia longitubulata . The phylogenetic position of Sarcoporia is discussed.
Scraping Airlines Bots: Insights Obtained Studying Honeypot Data (2021)

Airline websites are the victims of unauthorised online travel agencies and aggregators that use armies of bots to scrape prices and flight information. These so-called Advanced Persistent Bots (APBs) are highly sophisticated. On top of the valuable information taken away, these huge quantities of requests consume a very substantial amount of resources on the airlines' websites. In this work, we propose a deceptive approach to counter scraping bots. We present a platform capable of mimicking airlines' sites changing prices at will. We provide results on the case studies we performed with it. We have lured bots for almost 2 months, fed them with indistinguishable inaccurate information. Studying the collected requests, we have found behavioural patterns that could be used as complementary bot detection. Moreover, based on the gathered empirical pieces of evidence, we propose a method to investigate the claim commonly made that proxy services used by web scraping bots have millions of residential IPs at their disposal. Our mathematical models indicate that the amount of IPs is likely 2 to 3 orders of magnitude smaller than the one claimed. This finding suggests that an IP reputation-based blocking strategy could be effective, contrary to what operators of these websites think today.
Septum magnet coil design principles. [Guide to using the computer code TRIM for coil design] (1979)

A guide is presented for the design of the coils of septum magnets using the computer program TRIM. A method is described that eliminated the trial and error procedure and produces a coil design in only 2 TRIM calculations. The first TRIM calculation determines the position of the ampere turns to drive the yoke. The second TRIM calculation verifies the coil design.
Metabolomics Investigation To Shed Light on Cheese as a Possible Piece in the French Paradox Puzzle (2015)

An NMR-based metabolomics approach was used to investigate the differentiation between subjects consuming cheese or milk and to elucidate the potential link to an effect on blood cholesterol level. Fifteen healthy young men participated in a full crossover study during which they consumed three isocaloric diets with similar fat contents that were either (i) high in milk, (ii) high in cheese with equal amounts of dairy calcium, or (iii) a control diet for 14 days. Urine and feces samples were collected and analyzed by NMR-based metabolomics. Cheese and milk consumption decreased urinary choline and TMAO levels and increased fecal excretion of acetate, propionate, and lipid. Compared with milk intake, cheese consumption significantly reduced urinary citrate, creatine, and creatinine levels and significantly increased the microbiota-related metabolites butyrate, hippurate, and malonate. Correlation analyses indicated that microbial and lipid metabolism could be involved in the dairy-induced effects on blood cholesterol level.