gebhart/patrepeval huggingface dataset:
Abstract 2338: CD39+ Treg cooperate with a CD73-expressing Th1/Th17 subset for Adenosine-mediated immunosuppression in human breast tumors (2016)

Abstract Our group and others have previously reported that Treg infiltrating (Ti-Treg) breast tumors have a negative impact on patients’ outcome. We further reported their selective recruitment in the tumor environment through CCL22 secretion and expansion upon ICOS engagement by plasmacytoïd dendritic cells. Here, we investigated the mechanism of Ti-Treg mediated suppression and observed that Ti-Treg express high CD39 levels. CD39 is an ectonucleotidase that cooperates with CD73 to degrade the danger signal ATP into immunosuppressive Adenosine (Ado). The potency of Ado mediated suppression is illustrated in Adenosine-Deaminase (ADA)-deficient patients unable to degrade Ado and developing severe immunodeficiency. We further show that, in contrast to murine Treg, human CD39+Treg do not express CD73 enabling them only to degrade ATP into AMP. Within T cells, CD73 expression was mainly associated with naïve CD8+ T cells and a subset of memory conventional CD4+ T cells (Tconv) that exhibit Th1/Th17 characteristics (CXCR3+CCR6+CCR4negIFNγhighIL17+). CD39+ Treg isolated from healthy donor blood, in presence of exogenous ATP, potently inhibit purified CD73+ but not CD73neg Tconv, proliferation and cytokine production (IFNγ, TNFα). By using enzymatic inhibitors, we demonstrated the involvement of CD39 and CD73 through Treg/Tconv cooperation for Ado mediated immunosuppression. Of importance, when integrated in [Treg-CD4+CD73+] high density coculture, CD4+CD73neg T cells expressing similar levels of Ado receptors (A2A, A2B) are also inhibited. In conclusion, our findings support the existence of an Ado mediated immunosuppression loop in the tumor through cooperation between CD39highTreg and CD73-expressing Th1/Th17 subsets in the breast tumor environment. The research leading to these results has received funding from the European Community's Seventh Framework Program (FP7/2007-2013) under grant agreement n°602200. Citation Format: Nicolas Gourdin, Céline Rodriguez, Selena Vigano, Isabelle Durand, Julien Faget, Camilla Jandus, Jean Yves Blay, Pedro Romero, Christine Menetrier-Caux, Christophe Caux. CD39+ Treg cooperate with a CD73-expressing Th1/Th17 subset for Adenosine-mediated immunosuppression in human breast tumors. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2338.
Finite-difference time domain simulation of light propagation in blue phase liquid crystals (2014)

We present the results of numerical experiments of propagation of circularly polarized light through Cholesteric Blue Phase Liquid Crystals (BPLC) and make a comparison with experimental results. Commercial tool “Lumerical FDTD” was used to perform the computations.
Foldable and Stretchable Liquid Metal Planar Inverted Cone Antenna (2009)

A mechanically flexible planar inverted cone antenna (PICA) for ultrawideband (UWB) applications is presented. It can be both folded and stretched significantly without permanent damage or loss of electrical functionality. The antenna is manufactured with a process in which conductors are realized by injecting room temperature liquid metal alloy into micro-structured channels in an elastic dielectric material. The elastic dielectric material together with the liquid metal enables bending with a very small radius, twisting, and stretching along any direction. Port impedance and radiation characteristics of the non-stretched and stretched antenna are studied in simulations and experiments. The presented antenna has a return loss better than 10 dB within 3-11 GHz and a radiation efficiency of > 70% over 3-10 GHz, also when stretched. Tests verify that stretching up to 40% is possible with maintained electrical performance. The presented antenna is useful for example for body-worn antennas and in applications in harsh environments where mechanical flexibility helps improve durability.
A vir-repressed gene of Bordetella pertussis is required for virulence (1992)

Coordinate regulation of gene expression in Bordetella pertussis is controlled by the products of the vir locus, BvgA and BvgS. In the presence of modulating signals such as MgSO4 and nicotinic acid, expression of vir-activated genes (vag) is reduced, while expression of vir-repressed genes (vrg) is maximal. We have cloned one of these vir-repressed genes, vrg-6, in Escherichia coli. DNA sequencing has shown that vrg-6 is contained on a single EcoRI restriction endonuclease fragment and is predicted to code for a protein of 105 amino acids with a molecular weight of 11,441. The predicted protein product appears to have two domains, one consisting of seven hydrophobic proline-rich pentameric repeats and the other consisting of five alkaline trimeric repeats. Southern blot analysis has revealed vrg-6-homologous sequences in the chromosomes of Bordetella bronchiseptica and Bordetella parapertussis, but, unlike Bordetella pertussis, these species do not express vrg-6-homologous RNA when grown under modulating conditions. In order to assess the role of vrg gene products in B. pertussis pathogenesis, two 18323 derivatives which harbor TnphoA insertions in vrg genes were analyzed in a mouse model of respiratory infection. Strain SK6, which carries a vrg-6::TnphoA mutation, failed to induce lymphocytosis and was significantly less able to colonize lungs and trachea than its parent strain 18323 or than SK18, which harbors a TnphoA fusion in the vrg-18 locus. This is the first evidence that a vir-repressed gene may play an important role in the virulence of B. pertussis and the pathogenesis of whooping cough.
Reconstruction of Signals Drawn from a Gaussian Mixture from Noisy Compressive Measurements: MMSE Phase Transitions and Beyond. (2013)

Abstract—This paper determines to within a single measure-ment the minimum number of measurements required to success-fully reconstruct a signal drawn from a Gaussian mixture model in the low noise regime. The method is to develop upper and lower bounds that are a function of the maximum dimension of the linear subspaces spanned by the Gaussian mixture components. It is shown that an n-dimensional signal that is s-sparse with non-zero components drawn independent identically distributed (i.i.d.) from a Gaussian mixture distribution can be reconstructed perfectly in the low-noise regime with exactly s+1 measurements. This estimate is tighter and sharper than standard bounds on the minimum number of measurements needed to recover sparse signals associated with a union of subspaces model. It shows that it is possible to achieve the performance of intractable `0-pseudonorm recovery algorithms using the optimal closed-form conditional mean estimator within the Bayesian (Compressive Sensing) CS paradigm. The method not only reveals the existence or absence of a minimum mean-squared error (MMSE) error floor (phase transition) but also provides insight into the MMSE decay via multivariate generalizations of the MMSE dimension and the MMSE power offset that are a function of the inter-action between the geometrical properties of the kernel and the Gaussian mixture. These results apply not only to standard linear random Gaussian measurements but also to linear kernels that minimize the MMSE. It is shown that optimal kernels do not change the number of measurements associated with the MMSE phase transition, rather they affect the sensed power required to achieve a target MMSE in the low-noise regime. Index Terms—Compressive sensing, Gaussian mixtures, recon-
Influence of Fin and Finger Number on TID Degradation of 16-nm Bulk FinFETs Irradiated to Ultrahigh Doses (2021)

This article investigates the fin- and finger-number dependence of the total ionizing dose (TID) degradation in 16-nm bulk Si FinFETs at ultrahigh doses. n- and p-FinFETs designed with different numbers of fins and fingers are irradiated up to 500 Mrad(SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) and then annealed for 24 h at 100 °C. The TID responses of nFinFETs are insensitive to the fin number, as dominated by border and interface trap generation in shallow trench isolation (STI) and/or gate oxide. However, pFinFETs show a visible fin-number dependence with worst tolerance of transistors with the smallest number of fins. The fin number dependence may be related to a larger charge trapping in STI located at the opposite lateral sides of the first and last fins. In addition, both n- and p-FinFETs exhibit an almost TID insensitivity to the finger number. During the design of integrated circuits, the TID tolerance of electronic systems can be enhanced by preferably using transistors with a higher number of fins than fingers.
Tunable coupling between Xmon qubit and coplanar waveguide resonator* (2019)

Realization of a flexible and tunable coupling scheme among qubits is critical for scalable quantum information processing. Here, we design and characterize a tunable coupling element based on Josephson junction, which can be adapted to an all-to-all connected circuit architecture where multiple Xmon qubits couple to a common coplanar waveguide resonator. The coupling strength is experimentally verified to be adjustable from 0 MHz to about 40 MHz, and the qubit lifetime can still be up to <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mn>12</mml:mn> <mml:mspace width="0.50em"/> <mml:mi mathvariant="normal">μ</mml:mi> <mml:mi mathvariant="normal">s</mml:mi> </mml:math> in the presence of the coupling element.
Trajectory Forecast as a Rapid Response to the Deepwater Horizon Oil Spill (2011)

In response to the Gulf of Mexico Deepwater Horizon oil spill, a Lagrangian trajectory modeling system was implemented immediately upon spill onset by marshaling numerical model and satellite remote sensing resources available from existing coastal ocean-observing activities. Surface oil locations inferred from satellite imagery were used to re-initialize the positions of virtual particles in this ensemble of trajectory models, and the particles were tracked using forecast surface currents, with new particles added to simulate the continual release of oil from the well. A challenge to this modeling effort was that much information remained unknown throughout the spill event, with additional uncertainty due to intensive mitigation activities. By frequently re-initializing the trajectory models with satelliteinferred locations, the effects of in situ mitigation and forecast error growth were implicitly accounted for and minimized. The simulated surface oil trajectories were compared to the satellite observations in subsequent forecast cycles for veracity testing. Although similar results were obtained, in general, differences were seen in the simulated trajectories by different models. However, no one model performed consistently better or worse than the others throughout the event with one exception. The lessons learned from the event may be useful in preparing rapid trajectory forecast systems in the future.
Promoting Interface and Knowledge Sharing: A Joint Project between General and Special Education Preservice Teachers (2012)

This article reports the findings of a joint unit plan critique project between two preservice teacher cohorts seeking teacher certification in general education and special education respectively. The paper addressed three questions: 1) What common affordances does this joint project have for the general and special education preservice teachers? 2) What unique affordances does it have for each of the groups? 3) What do the preservice teachers learn about the use of visuals, technology, and UDL principles to create accessible math lessons for all students? The results showed that the project impacted positively on the preservice teachers by allowing them to gain deeper understanding of professional collaboration and use of technology and visual resources to differentiate instruction for all students.
Properties of Electron-Hole Droplets in Germanium (1974)

Studies of light scattering by the electron-hole-droplets /EHD/ give information about the EHD concentration in different conditions. EHD formation time and EHD velocity in inhomogeneously deformed Ge are measured as well as polarization of the EHD radiation induced by the uniaxial stress.
AAC Kongsore oat (2022)

AAC Kongsore is a white-hulled spring oat ( Avena sativa L.) cultivar selected and developed under organic management. AAC Kongsore had high yields under organic and conventional production systems, compared to check cultivars (AAC Oravena, Leggett, AC Morgan and CDC Dancer). AAC Kongsore has good physical and milling quality traits.
Increased Serum Phospholipase A2 Activity in Advanced Chronic Liver Disease as an Expression of the Acute Phase Response (1993)

Phospholipase A2 (PLA2) modifications were investigated in patients with acute and chronic liver diseases, PLA2 variations were related to indices of liver function as well as to parameters of the acute phase response. Serum PLA2 activity modifications were fluorimetrically measured in 105 patients affected by acute and chronic liver diseases or extra-hepatic diseases. One-way ANOVA demonstrated a significant difference among groups (F = 4.53, P < 0.001); Bonferroni's test for pairwise comparisons showed that patients with hepatocellular carcinoma had higher mean values than subjects with benign extra-hepatic diseases (P < 0.01) and mild chronic liver disease (P < 0.05). Multiple regression analysis, performed choosing PLA2 as the dependent variable and blood urea nitrogen, C-reactive protein, alkaline phosphatase and alpha 1-fetoprotein as predictor variables was significant (multiple R = 0.7056, multiple R2 = 0.4978, F = 15.36, P = < 0.0001). The standardized regression coefficients found to be significant were those of C-reactive protein, blood urea nitrogen and alpha 1-fetoprotein. In conclusion, in patients with chronic liver disease, serum PLA2 activity increases parallel to disease severity and accompanies the expression of proteins of the acute phase response that, like PLA2 activity, increase in serum while liver synthesis declines.
An-26 BUS (2014)

Antonow An-26 BUS (Aufklarungsflugzeug, Prototyp) - Modernisierungsvariante der Translatorversion An-26 RT, erster Umbau Anfang 2007 im KiAS Aviant.
Use of Coefficient of Variation in Assessing Variability of Quantitative Assays (2002)

We have derived the mathematical relationship between the coefficient of variation associated with repeated measurements from quantitative assays and the expected fraction of pairs of those measurements that differ by at least some given factor, i.e., the expected frequency of disparate results that are due to assay variability rather than true differences. Knowledge of this frequency helps determine what magnitudes of differences can be expected by chance alone when the particular coefficient of variation is in effect. This frequency is an operational index of variability in the sense that it indicates the probability of observing a particular disparity between two measurements under the assumption that they measure the same quantity. Thus the frequency or probability becomes the basis for assessing if an assay is sufficiently precise. This assessment also provides a standard for determining if two assay results for the same subject, separated by an intervention such as vaccination or infection, differ by more than expected from the variation of the assay, thus indicating an intervention effect. Data from an international collaborative study are used to illustrate the application of this proposed interpretation of the coefficient of variation, and they also provide support for the assumptions used in the mathematical derivation.
First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent (2015)

We previously identified ONC201 (TIC10) as a first-in-class orally active small molecule with robust antitumor activity that is currently in clinical trials in advanced cancers. Here, we further investigate the safety characteristics of ONC201 in preclinical models that reveal an excellent safety profile at doses that exceed efficacious doses by 10-fold. In vitro studies indicated a strikingly different dose-response relationship when comparing tumor and normal cells where maximal effects are much stronger in tumor cells than in normal cells. In further support of a wide therapeutic index, investigation of tumor and normal cell responses under identical conditions demonstrated large apoptotic effects in tumor cells and modest anti-proliferative effects in normal cells that were non-apoptotic and reversible. Probing the underlying mechanism of apoptosis indicated that ONC201 does not induce DR5 in normal cells under conditions that induce DR5 in tumor cells; DR5 is a pro-apoptotic TRAIL receptor previously linked to the anti-tumor mechanism of ONC201. GLP toxicology studies in Sprague-Dawley rats and beagle dogs at therapeutic and exaggerated doses revealed no dose-limiting toxicities. Observations in both species at the highest doses were mild and reversible at doses above 10-fold the expected therapeutic dose. The no observed adverse event level (NOAEL) was ≥42 mg/kg in dogs and ≥125 mg/kg in rats, which both correspond to a human dose of approximately 1.25 g assuming standard allometric scaling. These results provided the rationale for the 125 mg starting dose in dose escalation clinical trials that began in 2015 in patients with advanced cancer.
Design and characteristics of high pulse repetition rate and high average power excimer laser systems (1991)

The authors describe the design and the performance characteristics of an X-ray preionized discharge pumped XeCl laser system operated at very high repetition rate frequency and high average power (200 W). The laser system is mainly composed of a fast flow subsonic closed cycle wind tunnel, a laser head, a high average power electrical excitation system, and an X-ray preionization source. The laser head design and the damping of acoustic waves induced by fast electrical energy deposition of 50 J/L bar allows this device to be operated at repetition rate frequencies of up to approximately=1700 Hz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Design of an F1 hybrid breeding strategy for ryegrasses based on selection of self-incompatibility locus-specific alleles (2015)

Relatively modest levels of genetic gain have been achieved in conventional ryegrass breeding when compared to cereal crops such as maize, current estimates indicating an annual improvement of 0.25-0.6% in dry matter production. This property is partially due to an inability to effectively exploit heterosis through the formation of F1 hybrids. Controlled crossing of ryegrass lines from geographically distant origins has demonstrated the occurrence of heterosis, which can result in increases of dry matter production in the order of 25%. Although capture of hybrid vigor offers obvious advantages for ryegrass cultivar production, to date there have been no effective and commercially suitable methods for obtaining high proportions of F1 hybrid seed. Continued advances in fine-scale genetic and physical mapping of the gametophytic self-incompatibility (SI) loci (S and Z) of ryegrasses are likely in the near future to permit the identification of closely linked genetic markers that define locus-specific haplotypes, allowing prediction of allelic variants and hence compatibility between different plant genotypes. Given the availability of such information, a strategy for efficient generation of ryegrass cultivars with a high proportion of F1 hybrid individuals has been simulated, which is suitable for commercial implementation. Through development of two parental pools with restricted diversity at the SI loci, relative crossing compatibility between pools is increased. Based on simulation of various levels of SI allele diversity restriction, the most effective scheme will generate 83.33% F1 hybrids. Results from the study, including the impact of varying flowering time, are discussed along with a proposed breeding design for commercial application.
Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens (serum-free medium/aflatoxin Bs/benzo(alpyrene/N-nitrosodimethylamine) (2016)

Normal human liver tissue and cultured hu- man hepatocytes are valuable models to study xenobiotic metabolism and toxicity, but they only have a limited in vitro life-span and are not readily available. This report describes the establishment of replicative cultures of human adult liver epithelial cells in serum-free medium. The longevity of three of these cultures, derived from different donors, was extended by introduction of the simian virus 40 large T antigen gene. Two cell lines, THLE-2 and -3, established with a recombinant simian virus 40 large T antigen virus have undergone >100 population doublings, are nontumorigenic when injected into athymic nude mice, have near-diploid karyotypes, and do not express a-fetoprotein. The cells express cytokeratin 18 and albumin in early passage, whereas higher-passage cells in logarithmic-phase growth also express cytokeratin 19. THLE-2 and -3 cells metabolize benzo(a)pyrene, N-nitrosodimethyl- amine, and aflatoxin B1 to their ultimate carcinogenic metab- olites that adduct DNA, which indicates functional cytochrome P450 pathways. Other enzymes involved in metabolism of chemical carcinogens, such as epoxide hydrolase, NADPH cytochrome P450 reductase, superoxide dismutase, catalase, glutathione S-transferases, and glutathione peroxidase are also retained by THLE cells. Thus, these immortalized human liver cells constitute an in vitro model for pharmacotoxicological studies and for the investigation of etiology and pathogenesis of human hepatocellular carcinoma.
Assessing and Maturing Technology Readiness Levels (2011)

Having considered architecture and design of an SHM system, we next turn to maturity assessment of specific SHM technologies. Like the concept of SHM itself, many of these technologies will be new, untested, and immature. Many of them are needed in the short term, and must be matured from concept to flight-proven applications within 5 to 10 years. Furthermore, the technologies themselves are often inherently complex and difficult to validate. This chapter focuses on these issues of SHM development, and aims to facilitate technology maturation and certification.
An efficient load balancing scheme for resilient search in KAD peer to peer networks (2009)

In this paper, we propose an efficient multiple hashes method (called KAD-N) to balance peer loads in the KAD (Kademlia) network. Note that N is the maximum hash times, determining by a cost-effectiveness factor. This method hashes the keyword of an object r times to produce a key for publishing objects, where r is a random number and 1 ≤ r ≤ N. Simulation results show that the distribution of indexes is more balanced using the proposed KAD-N method. We found out that N = 7 (KAD-7) is the optimal setting in our simulation environment. We used a standard deviation to evaluate the proposed load balancing method. Simulation results also show that KAD-7 has the search hit rate close to 100% and the standard deviation is 44% less than that of the KAD (i.e., KAD-1), which means the proposed method is more load balancing than the KAD. However, KAD-7 has 7% extra traffic overhead. By increasing the search hit rate, KAD-N improves the search resilience of KAD networks with failed peers. Furthermore, the proposed KAD-N method can easily be extended to other DHT-based P2P networks.