gebhart/patrepeval huggingface dataset:
Antibacterial Diamines Targeting Bacterial Membranes (2016)

Antibiotic resistance is a growing threat to human health exacerbated by a lack of new antibiotics. We now describe a series of substituted diamines that produce rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus and stationary-phase bacteria. These compounds reduce biofilm formation and promote biofilm dispersal in Pseudomonas aeruginosa. The most potent analogue, 3 (1,13-bis{[(2,2-diphenyl)-1-ethyl]thioureido}-4,10-diazatridecane), primarily acts by depolarization of the cytoplasmic membrane and permeabilization of the bacterial outer membrane. Transmission electron microscopy confirmed that 3 disrupts membrane integrity rapidly. Compound 3 is also synergistic with kanamycin, demonstrated by the checkerboard method and by time-kill kinetic experiments. In human cell toxicity assays, 3 showed limited adverse effects against the HEK293T human kidney embryonic cells and A549 human adenocarcinoma cells. In addition, 3 produced no adverse effects on Caenorhabditis elegans development, survival, and reproduction. Collectively, diamines related to 3 represent a new class of broad-spectrum antibacterials against drug-resistant pathogens.
The Stimulation Treatment Pressure Record An Overlooked Formation Evaluation Tool (1969)

Pressure transient analyses of stimulation treatment pressure records Pressure transient analyses of stimulation treatment pressure records give formation permeability and show the condition of the formation around the wellbore both before and after treatment. Introduction Much has been written in recent years about transient testing theory and its application in understanding well behavior. The literature illustrates various special transient analysis techniques and their interpretations; however, in the past, one important source of transient data has been overlooked. This source is the stimulation treatment pressure record. On every well that is stimulated by a service company, a treatment report giving pertinent well data, materials and volumes, and pumping times is prepared, and a copy is presented to the oil company representative. In nearly every case, the treating pressures are recorded by either a strip chart or a circular clock recorder. Either the original pressure chart or a copy is given to the customer if he requests it. During the treatment, fluids are injected into the well, causing a pressure response that is recorded at the wellhead. At times the injection may be stopped for mixing of fluids. These injection pressure buildups and fall-offs during the treatment can be calculated and interpreted to determine the condition of the wellbore and the formation transmissibility. The engineer can check the validity of the result by calculating expected production before and after the treatment and comparing with the actual well production. Statement of Theory and Definitions In the analysis of drawdown pressures at a constant well production rate in an infinite reservoir, the point source solution is used. This equation is also valid for describing the behavior of a well in a bounded reservoir prior to the occurrence of any boundary effects. Except for the sign of the production rate, q, the same transient equation applies to well pressure buildup at a constant injection rate. Although this is well known mathematically, it has not been used in actual testing in our experience because of the supposed problem of holding a constant injection rate and because of possible filtering at the formation face in the wellbore. possible filtering at the formation face in the wellbore. In actual practice, though, as we will see later, these problems are not a real handicap in most wells particularly problems are not a real handicap in most wells particularly during early injection times. All the same equations developed for constant rate drawdown can be applied to constant injection rate buildup. An advantage of using a constant injection rate buildup test is that the liquid injected is not as compressible as most produced fluids; therefore, the wellbore unloading factor found in producing wells is not significant in an injection test. producing wells is not significant in an injection test. The following approximate equations (Eqs. 2 and 3) are well known and apply when tdw = (0.000264kt/ccrw2) greater than 100. JPT P. 951
Review on Progressive Freeze Concentration Designs (2015)

Progressive freeze concentration (PFC) is a process where only a large single ice crystal is formed in the system and grown on the cooling surface so that the separation between the ice crystal and the mother solution is very easy. This makes the system very simple and leads to a lower cost. The conventional setup of PFC produces ice with high purity but lower productivity than suspension freeze concentration (SFC). The volume of ice produced is also usually low. Hence, continued areas of the development for PFC system include the quest for improved productivity and better efficiency. Different kinds of design have been investigated, which are easy to operate and cost-effective besides the ability to obtain high quality of product and better efficiency of the system. The PFC system is recognized as a good alternative if high-quality products can be produced with higher productivity. In this article, previous researches on PFC designs were reviewed for the purpose of providing an understanding on methods of designing a PFC system and also to provide references for future application of PFC.
Comparing Channel Emulation Algorithms by Using Plane Waves and Spherical Vector Waves in Multiprobe Anechoic Chamber Setups (2019)

This paper evaluates the performances of channel emulation algorithms in the multiprobe anechoic chamber (MPAC) by using plane wave (PW) and spherical vector wave (SVW) theories. Channel emulation in MPAC enables the over-the-air (OTA) testing of performances of wireless devices under realistic propagation scenarios, through setting excitation voltages of probes and utilizing the polarized radiation patterns, locations, and orientations of probe antennas to emulate desired fields in test zone. Accurate emulation of radio wave propagation in target scenario guarantees that the device under test (DUT) be assessed fairly in the laboratory. Dynamic multipath scenario and orthogonal polarization can be emulated by exciting the multiple probes in such a way that the total fields from probes resemble the target impinging field in the test zone. The excitation voltages can be either calculated by PW or SVW theories. Despite the fact that PW and SVW are mathematically equal in the far field, different treatments on rotation and translation of waves as well as different linear equations used in two methods result in different computed voltages, hence, different emulated fields. The emulation performances of the two methods with different MPAC setups (e.g., test zone size, probe number, probe sphere radius, and probe directivity) are investigated. Both scenarios of the 2-D field emulation with the 2-D probe configuration and the 3-D (or 2.5-D) field emulation with the 3-D probe configuration are discussed, and instructions on how to wisely use the emulation algorithm are provided.
A comparison of recurrent and isolated small‐for‐gestational‐age term births (1991)

In this study, based on total Western Australian singleton Caucasian births, women who had repeatedly given birth to small-for-gestational-age (SGA) term infants ('repeater' mothers) were compared with multiparous women who had had only one such infant ('non-repeater' mothers). Women with any preterm births were excluded. The study population comprised 678 repeater and 986 non-repeater mothers. Multiple logistic regression analysis indicated that weight loss or static weight in the third trimester of pregnancy, paternal smoking, low maternal birthweight, short maternal height and unknown family disease history were independent risk factors for repeater status compared with non-repeaters. The risk associated with paternal smoking was confined to mothers who were non-smokers themselves. There may have been a direct association between paternal smoking and recurrent fetal growth retardation or paternal smoking may have acted as a 'marker' for certain behavioural, environmental, social and economic factors which were not measured. Neonatal outcome was worse for the SGA infants of non-repeater mothers than for those of repeater mothers, although the latter were significantly more likely to weight less than 2500 grams.
A PosterioriError Estimation for Reduced-Basis Approximation of Parametrized Elliptic Coercive Partial Differential Equations: “Convex Inverse” Bound Conditioners (2002)

We present a technique for the rapid and reliable prediction of linear-functional outputs of elliptic coercive partial differential equations with affine parameter dependence. The essential components are (i ) (provably) rapidly convergent global reduced-basis approximations – Galerkin projection onto a space WN spanned by solutions of the governing partial differential equation at N selected points in parameter space; (ii ) a posteriori error estimation – relaxations of the error-residual equation that provide inexpensive bounds for the error in the outputs of interest; and ( iii ) off-line/on-line computational procedures – methods which decouple the generation and projection stages of the approximation process. The operation count for the on-line stage – in which, given a new parameter value, we calculate the output of interest and associated error bound – depends only on N (typically very small) and the parametric complexity of the problem; the method is thus ideally suited for the repeated and rapid evaluations required in the context of parameter estimation, design, optimization, and real-time control. In our earlier work we develop a rigorous a posteriori error bound framework for reduced-basis approximations of elliptic coercive equations. The resulting error estimates are, in some cases, quite sharp: the ratio of the estimated error in the output to the true error in the output, or effectivity , is close to (but always greater than) unity. However, in other cases, the necessary “bound conditioners” – in essence, operator preconditioners that (i ) satisfy an additional spectral “bound” requirement, and (ii ) admit the reduced-basis off-line/on-line computational stratagem – either can not be found, or yield unacceptably large effectivities. In this paper we introduce a new class of improved bound conditioners: the critical innovation is the direct approximation of the parametric dependence of the inverse of the operator (rather than the operator itself); we thereby accommodate higher-order (e.g., piecewise linear) effectivity constructions while simultaneously preserving on-line efficiency. Simple convex analysis and elementary approximation theory suffice to prove the necessary bounding and convergence properties.
Expression of antisense nodulin‐35 RNA in Vigna aconitifolia transgenic root nodules retards peroxisome development and affects nitrogen availability to the plant (1993)

A nodulin-35 (N-35) cDNA encoding nodule-specific uricase (EC 1.7.3.3.) was isolated from a Vigna aconitifolia (mothbean) root nodule cDNA library. Sequence analysis of Vigna uricase (VN-35) cDNA revealed 90% homology to that of soybean. The VN-35 cDNA was inserted in the antisense orientation downstream of the caMV-35S promoter, and transgenic hairy roots were formed on Vigna plants using Agrobacterium rhizogenes. Infection with Bradyrhizobium (cowpea) gave rise to root nodules on transgenic hairy roots supported by the wild-type shoot. Expression of antisense VN-35 RNA was detected in transgenic nodules on individual roots using polymerase chain reaction (PCR). The nodules expressing antisense VN-35 RNA were smaller in size and showed lower uricase activity than nodules formed on the hairy roots transformed with a binary vector containing beta-glucuronidase (GUS) gene (used as control), and the plants exhibited nitrogen deficiency symptoms. Ultrastructural analysis and immunogold labeling with antibody against soybean N-35 revealed that the growth of peroxisomes was retarded in transgenic nodules expressing antisense VN-35 RNA. These data suggest that a reduction in ureide biosynthesis limits the availability of symbiotically reduced nitrogen to the plant. The nodules of tropical legumes appear to be specialized in nitrogen assimilation and are developmentally controlled to produce and transport ureides.
Evaluation ofDropImpact LoadforPortable Electronic Components (2005)

Amethod topredict impact load caused bythecollision of tworods isinvestigated inthis paper. Toobtain normal impact load, Hertzian lawisapplied toexpress thecontact compliance. Frictional force anddeformation oftwobodies arealsotaken into account. Somedropimpact tests and simulations areperformed withseveral heights andpositions toverify themodeling. Theresults ofcomparing analysis with experiment showthat frictional force anddeformation oftwo rodsgreatly affect theimpact load. Itisnoted that thefinite element method canalsopredict theimpact loadandthat slipping andsticking between tworodsduring impact are likely toaffect theimpact load.
Finding a new therapeutic approach for no-option Parkinsonisms: mesenchymal stromal cells for progressive supranuclear palsy (2016)

We have demonstrated for the first time that MSC administration is feasible in subjects with PSP. In these patients, in whom deterioration of motor function is invariably rapid, we recorded clinical stabilization for at least 6 months. These encouraging results pave the way to the next randomized, placebo-controlled phase-II study that will definitively provide information on the efficacy of this innovative approach. Trial registration ClinicalTrials.gov NCT01824121.
Foveal cone photoreceptor involvement in primary open-angle glaucoma (2010)

The integrity of the foveal cone outer segments, and the reflectance of the central ILM were impaired in POAG with advanced central visual field defects.
Crystal Growth and Scintillation Properties of Ce<sup>3+</sup> and Mg<sup>2+</sup> Co-Doped LiCaAlF<sub>6</sub> Single Crystal (2012)

Ce and Mg Co-Doped LiCaAlF 6 (LiCAF) Single Crystals Were Grown by Micro-Pulling-down (μ-PD) Method and the Optical and Scintillation Properties of Obtained Crystals Were Measured. The Grown Crystals Were Crack-Free and Had 30-50 mm in Length and 2 Mm in Diameter. Absorption Coefficients Were Proportional to the Ce Nominal Concentrations. the Radioluminescence Spectra under 5.5 Mev Alpha-Ray Irradiation Showed Emission Peak at 290 and 310 nm due to Ce 3+ 5d-4f Transitions, and Were Agreement with those of Ce Single-Doped LiCaF. The Highest Light Yield under 5.5 Mev Alpha-Ray Irradiation of Ce 4% and Mg 2% Co-Doped LiCaF Was Found to Be 0.6 Times than that of Lithium Glass Scintillator GS-20. Comparing the Light Yield of Licaf Samples with the Fixed Ce Nominal Concentration and Different Mg Co-Doped Concentrations, the Light Yield Increased with an Increase of Mg Nominal Concentration. the Alpha-Ray Excited Decay Times Were Constantly 45-50 ns.
Antiobesity activity of pluronic L-101. (1980)

Pluronic L-101, a hydrophobic surface-active agent, was a potent in-vitro inhibitor of human pancreatic lipase. When administered as a 1 percent or 3 percent dietary admix to meal-fed rats, pluronic L-101 produced a significant and dose-dependent decrease in body-weight gain while not affecting food consumption. Excretion of dietary fat in the feces was enhanced significantly in a dose-dependent manner during pluronic L-101 treatment. Pluronic F-68, a hydrophilic surface-active agent which was a poor in-vitro inhibitor of human pancreatic lipase, did not produce decreases in body-weight gain or increase fecal-fat excretion in rats. The decreased body-weight gain produced by pluronic L-101 was reflected in a decreased percentage of carcass fat; the percentage of carcass protein was unchanged. Liver wet weight was reduced significantly only at the 3 percent pluronic L-101 level. Serum levels of cholesterol, triglyceride and glucose remained unchanged. During pluronic L-101 treatment no overt signs of toxicity were observed.
Exact Compensation of Rotational Motion for Holographic Video Compression (2019)

Holographic video imposes impractical bitrates for storage and communication without compression.We introduce exact motion compensation in a codec using rotational transformation of angular spectrum and obtain SNR improvements of 20 dB over HEVC.
Mercury in organic chemistry. 33. A convenient synthesis of allenic and propargylic ketones via acylation of propargylic and allenic organomercurials, respectively (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleMercury in organic chemistry. 33. A convenient synthesis of allenic and propargylic ketones via acylation of propargylic and allenic organomercurials, respectivelyRichard C. Larock, Min Shine Chow, and Sarah J. SmithCite this: J. Org. Chem. 1986, 51, 13, 2623–2624Publication Date (Print):June 1, 1986Publication History Published online1 May 2002Published inissue 1 June 1986https://pubs.acs.org/doi/10.1021/jo00363a052https://doi.org/10.1021/jo00363a052research-articleACS PublicationsRequest reuse permissionsArticle Views316Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Analysis of Random-Walk Cuckoo Hashing (2011)

In this paper, we provide a polylogarithmic bound that holds with high probability on the insertion time for cuckoo hashing under the random-walk insertion method. Cuckoo hashing provides a useful methodology for building practical, high-performance hash tables. The essential idea of cuckoo hashing is to combine the power of schemes that allow multiple hash locations for an item with the power to dynamically change the location of an item among its possible locations. Previous work on the case where the number of choices is larger than two has analyzed breadth-first search, which is both inefficient in practice and currently has only a polynomial upper bound on the insertion time that holds with high probability. On the other hand, it does have expected constant amortized insertion time. Here we significantly advance the state of the art by proving a polylogarithmic bound that holds with high probability on the more efficient random-walk method, where items repeatedly kick out random blocking items until a free location for an item is found.
Systematic arrangement control of functional organic molecules (2022)

Systematic and precise arrangement control of functional organic molecules without changing both their molecular and layered structure was established.
Strength of incompatible amorphous polymer interfaces (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStrength of incompatible amorphous polymer interfacesJulious L. Willett and Richard P. WoolCite this: Macromolecules 1993, 26, 20, 5336–5349Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/ma00072a010https://doi.org/10.1021/ma00072a010research-articleACS PublicationsRequest reuse permissionsArticle Views362Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
FLASH-RT does not affect chromosome translocations and junction structures beyond that of CONV-RT dose-rates (2023)

The molecular and cellular mechanisms driving the enhanced therapeutic ratio of ultra-high dose-rate radiotherapy (FLASH-RT) over slower conventional (CONV-RT) radiotherapy dose-rate remain to be elucidated. However, attenuated DNA damage and transient oxygen depletion are among several proposed models. Here, we tested whether FLASH-RT under physioxic (4% O <sub>2</sub> ) and hypoxic conditions (≤2% O <sub>2</sub> ) reduces genome-wide translocations relative to CONV-RT and whether any differences identified revert under normoxic (21% O <sub>2</sub> ) conditions. We employed high-throughput rejoin and genome-wide translocation sequencing ( <i>HTGTS-JoinT-seq</i> ), using <i>S. aureus</i> and <i>S. pyogenes</i> Cas9 "bait" DNA double strand breaks (DSBs), to measure differences in bait-proximal repair and their genome-wide translocations to "prey" DSBs generated by electron beam CONV-RT (0.08-0.13Gy/s) and FLASH-RT (1×10 <sup>2</sup> -5×10 <sup>6</sup> Gy/s), under varying ionizing radiation (IR) doses and oxygen tensions. Normoxic and physioxic irradiation of HEK293T cells increased translocations at the cost of decreasing bait-proximal repair but were indistinguishable between CONV-RT and FLASH-RT. Although no apparent increase in chromosome translocations was observed with hypoxia-induced apoptosis, the combined decrease in oxygen tension with IR dose-rate modulation did not reveal significant differences in the level of translocations nor in their junction structures. Thus, Irrespective of oxygen tension, FLASH-RT produces translocations and junction structures at levels and proportions that are indistinguishable from CONV-RT.
Supplementary Table 1 from Myc-Mediated Transcriptional Repression by Recruitment of Histone Deacetylase (2023)

Supplementary Table 1 from Myc-Mediated Transcriptional Repression by Recruitment of Histone Deacetylase