gebhart/patrepeval huggingface dataset:
Structure-Property-Processing Correlations of Graphene Bioscaffolds for Proliferation and Differentiation of C2C12 Cells (2023)

Graphene - an atomically thin layer of carbon atoms arranged in a hexagonal lattice - has gained interest as a bioscaffold for tissue engineering due to its exceptional mechanical, electrical, and thermal properties. Graphene's structure and properties are tightly coupled to synthesis and processing conditions, yet their influence on biomolecular interactions at the graphene-cell interface remains unclear. In this study, C2C12 cells were grown on graphene bioscaffolds with specific structure-property- processing-performance (SP3) correlations. Bioscaffolds were prepared using three different methods - chemical vapor deposition (CVD), sublimation of silicon carbide (SiC), and printing of liquid phase exfoliated graphene. To investigate the biocompatibility of each scaffold, cellular morphology and gene expression patterns were investigated using the bipotential mouse C2C12 cell line. Using a combination of fluorescence microscopy and qRT-PCR, we demonstrate that graphene production methods determine the structural and mechanical properties of the resulting bioscaffold, which in turn determine cell morphology, gene expression patterns, and cell differentiation fate. Therefore, production methods and resultant structure and properties of graphene bioscaffolds must be chosen carefully when considering graphene as a bioscaffold for musculoskeletal tissue engineering.
Ultra-Sensitive Real-Time Single-DNA Molecules Detection at a Fused-Silica/Water Interface Using TIRFM Technique (2005)

School of Electrical Engineering Se, oul National Universtyi Se, oul 151-742, KoreaReceived February 21 2, 005Key Words : Single molecule detection, Microchip, TIRFM, Ultra-sensitiveMany scientific results are based on macroscopic obser-vations of group behavior of large numbers of molecules.Recent single molecule detection (SMD) techniques in freesolution have allowed for the direct observation andmanipulation of single biomolecules, which permitted theirdynamic behaviors and localization to be studied to provideinsight into molecular genetics,
Waveguide Absorption Spectroscopy of Bovine Serum Albumin in the Mid-Infrared Fingerprint Region (2019)

Protein sensing in biological fluids provides important information to diagnose many clinically relevant diseases. Mid-infrared (MIR) absorption spectroscopy of bovine serum albumin (BSA) is experimentally demonstrated on a germanium on silicon (GOS) waveguide in the 1900-1000 cm<sup>-1</sup> (5.3-10.0 μm) region of the MIR. GOS waveguides were shown to guide light up to a wavelength of 12.9 μm. The waveguide absorption spectrum of water, showing molecular bending vibrations, was obtained experimentally and compared with a theoretical model showing good agreement. Measurement of a concentration series of BSA protein in phosphate buffered saline (PBS) from 0.1 mg/mL to 100 mg/mL was performed on the waveguide using filter paper as a flow strip, and the amide I, II, and III peaks were observed and quantified.
Hydrostatic Implosion of GFRP Composite Tubes Studied by Digital Image Correlation (2015)

The mechanisms and pressure fields associated with the hydrostatic implosion of glass fiber reinforced polymer (GFRP) tubes with varying reinforcement are investigated using high-speed photography. Experiments are conducted in a large pressure vessel, designed to provide constant hydrostatic pressure throughout collapse. Three-dimensional (3D) digital image correlation (DIC) is used to capture full-field displacements, and dynamic pressure transducers measure the pressure pulse generated by the collapse. Results show that braided GFRP tubes release pressure waves with significantly greater impulse upon collapse as compared to filament-wound tubes, increasing their damage potential.
Anti-Helicopter Mine System Studies and Analyses (1989)

This document is a compilation of three studies and analyses pertaining to the Anti-Helicopter Mine system: (1) 'Concept for the Employment of the Anti-Helicopter Mine (AHM),' (2) 'Operational and Organizational Plan for the Anti-Helicopter Mine (AHM),' and (3) 'Force-on-Force Modeling and Analysis for the Anti-Helicopter Mine.'
Letter to the Editor: Comment on Choudhary, et al. Suprazygomatic Aponeurotic McLaughlin Myoplasty for Facial Reanimation (Ann Plast Surg. 2020;85:149–157) (2020)

Silan, Francesco MD; Consiglio, Fabio MD; Dell'Antonia, Francesco MD; Montagner, Giulia PhD; Trojan, Diletta MSc; Berna, Giorgio MDAuthor Information
Ultrafast photoisomerization studied by time-resolved photoelectron spectroscopy (2022)

Ultrafast photoinduced isomerization is a fundamental process governing molecular dynamics both in biologically relevant chromophores and in functional materials, e.g. those based on molecular switches and motors. It is widely accepted that the efficiency of isomerization is governed by the dynamics through conical intersections, the regions of the potential energy landscape, where two potential energy surfaces cross. Recent developments in computational chemistry can help identifying conical intersections in isolated chromophores molecules and describe the relaxation dynamics. However, the complex environments hosting the chromophores have a profound influence on the dynamics through conical intersection making direct application of these methods to “real life” problems a very challenging task and underscoring the importance of experimental investigations. Most all-optical time-resolved spectroscopic techniques cannot directly capture the dynamics at conical intersections both because it is very fast and because the gap between the two electronic states vanishes at the intersection. However, the XUV-based spectroscopic techniques and, in particular, XUV time-resolved photoelectron spectroscopy (TRPES) give promise in delivering detectable signals from the regions of conical intersections. TRPES of molecular chromophores requires application of photoemission methods to the liquid phase samples (molecular solutions). Our group has recently become the first to demonstrate liquid phase TRPES of organic molecules by combining an ultrafast tunable XUV source with a microliquid jet sample delivery method and time-of-flight photoelectron detection. In this contribution we will report on the recent results applying this method to the prototypical molecules, Methyl Orange and Metanil Yellow. The experimental results are complemented by high-level time-dependent density functional theory (TDDFT) surface hopping calculations to reveal electronic state involved in ultrafast relaxation of the molecules. We will further show preliminary results for several bio-mimetic chromophores and will discuss the experimental challenges of the techniques, when working with samples of low concentration and using different solvents.
SciAutonics‐Auburn Engineering's low‐cost high‐speed ATV for the 2005 DARPA grand challenge (2006)

Abstract This paper presents a summary of SciAutonics‐Auburn Engineering's efforts in the 2005 DARPA Grand Challenge. The areas discussed in detail include the team makeup and strategy, vehicle choice, software architecture, vehicle control, navigation, path planning, and obstacle detection. In particular, the advantages and complications involved in fielding a low budget all‐terrain vehicle are presented. Emphasis is placed on detailing the methods used for high‐speed control, customized navigation, and a novel stereo vision system. The platform chosen required a highly accurate model and a well‐tuned navigation system in order to meet the demands of the Grand Challenge. Overall, the vehicle completed three out of four runs at the National Qualification Event and traveled 16 miles in the Grand Challenge before a hardware failure disabled operation. The performance in the events is described, along with a success and failure analysis. © 2006 Wiley Periodicals, Inc.
IPCP: Immersive Parallel Coordinates Plots for Engineering Design Processes (2020)

Computational engineering design methods and tools are common practice in modern industry. Such approaches are integral in enabling designers to efficiently explore larger and more complex design spaces. However, at the same time, computational engineering design methods tend to dramatically increase the number of candidate solutions that decision-makers must interpret in order to make appropriate choices within a set of solutions. Since all candidate solutions can be represented in digital form together with their assessment criteria, evaluated according to some sort of simulation model, a natural way to explore and understand the complexities of the design problem is to visualize their multidimensional nature. The task now involves the discovery of patterns and trends within the multidimensional design space. In this work, we aim to enhance the design decision-making process by embedding visual analytics into an immersive virtual reality environment. To this end, we present a system called IPCP: immersive parallel coordinates plots. IPCP combines the well-established parallel coordinates visualization technique for high-dimensional data with immersive virtual reality. We propose this approach in order to exploit and discover efficient means to use new technology within a conventional decision-making process. The aim is to provide benefits by enhancing visualizations of 3D geometry and other physical quantities with scientific information. We present the design of this system, which allows the representation and exploration of multidimensional scientific datasets. A qualitative evaluation with two surrogate expert users, knowledgeable in multidimensional data analysis, demonstrate that the system can be used successfully to detect both known and previously unknown patterns in a real-world test dataset, producing an early indicative validation of its suitability for decision support in engineering design processes.
Guaranteeing end-to-end timing constraints by calibrating intermediate processes (1994)

This paper presents a comprehensive design methodology for guaranteeing \nend-to-end requirements of real-time systems. Applications are \nstructured as a set of process components connected by asynchronous \nchannels, in which the endpoints are the system's external inputs and \noutputs. Timing constraints are then postulated between these inputs \nand outputs; they express properties such as end-to-end propagation \ndelay, temporal input-sampling correlation, and allowable separation\ntimes between updated output values.\n\nThe automated design method works as follows: First the end-to-end \nrequirements are transformed into a set of intermediate rate constraints \non the tasks, and new tasks are created to correlate related inputs. \nThe intermediate constraints are then solved by an optimization \nalgorithm, whose objective is to minimize CPU utilization. If the \nalgorithm fails, a restructuring tool attempts to eliminate bottlenecks by \ntransforming the application, which is then re-submitted into the \nassignment algorithm. The final result is a schedulable set of fully \nperiodic tasks, which collaboratively maintain the end-to-end constraints.\n(Also cross-referenced as UMIACS-TR-94-58)
Proposal of n-gram Based Algorithm for Malware Classification (2011)

Obfuscation techniques degrade the n-gram features of binary form of the malware. In this study, methodology to classify malware instances by using n-gram features of its disassembled code is presented. The presented statistical method uses the n-gram features of the malware to classify its instance with respect to their families. n-gram is a fixed size sliding window of byte array, where n is the size of the window. The contribution of the presented method is capability of using only one vector to represent malware subfamily which is called subfamily centroid. Using only one vector for classification simply reduces the dimension of the n- gram space. Experimental results are performed over a fairly large data set, which is being collected through Computer Emergency Response Team (CERT) activities in the National Research Institute of Electronics and Cryptology, to illustrate the effectiveness of the proposed malware classification methodology.
Structure-property relationship in Mg-doped La0.75Sr0.25Mn0.5Cr0.5O3 anode for solid oxide fuel cell (2014)

Lanthanum strontium chromium manganite (LSCM) has been found to be a potential candidate for SOFC anode to use in hydrocarbon fuels. Mg-doped LSCM has been synthesized by solid state reaction and tested for its sulphur tolerance when used as anode of solid oxide fuel cells. This material shows redox stability, compatibility with other cell components, acceptable level of cocking and sulphur tolerance. Structural studies using X-ray and neutron powder diffraction shows that the materials crystallize in the rhombohedral symmetry in the R-3C space group. Thermogravimetric analysis shows stable redox behaviour similar to LSCM. Microstructural analysis shows porous structure which is essential for an anode material. Performance of this material as an anode of SOFC has been tested in H2, CH4 and H2S/H2/CH4 atmosphere at different temperatures. Impedance analysis show that best performance can be achieved at about 870 °C corresponding to the polarization resistance of 0.5 ohm/cm2 in pure H2 and 1.0 ohm/cm2 in CH4. Microstructural analysis after cell preparations shows a good lamination between the electrolyte and anode.
Spinal Cord Injury in Pediatric Patients (2007)

This chapter contains section titled: Introduction Early nonsurgical management of pediatric SCI: the use of corticosteroids Stabilization of the pediatric spinal column Conclusions
Hemoglobin-Based Hydrogen Peroxide Biosensor Tuned by the Photovoltaic Effect of Nano Titanium Dioxide (2005)

The photovoltaic effect of titanium dioxide (TiO2) nanoparticles, induced by ultraviolet light, can greatly improve the catalytic activity of hemoglobin as a peroxidase, with the sensitivity increased nearly 3-fold and the detection limit lowered 2 orders, in contrast to the catalytic reactions in the dark, which indicates a possible method to tune the properties of proteins for development of photocontrolled protein-based biosensors.
Crosslinked Polyvinylalcohol Hydrogels as Vehicles for Hydrophilic Drugs (2000)

Polyvinylalcohol crosslinked with succinyl, adipoyl, or sebacoyl chloride at two different degrees of crosslinking was prepared and employed as a supporting material for aqueous topical gels containing propranolol hydrochloride, which was chosen as a hydrophilic model drug suitable for transdermal delivery. We analysed the effect of the nature of the crosslinker and the degree of crosslinking on drug permeation through porcine skin by means of the permeation parameters obtained from the gels and the corresponding aqueous solution. The gels showed greater drug permeation than the liquid solution due to an increase in drug solubility in the skin. Increasing degree of crosslinking and decreasing crosslinker acyl chain length in the gel enhance the drug permeability through the skin.
The American College of Rheumatology (ACR) Core Data Set and derivative "patient only" indices to assess rheumatoid arthritis. (2006)

Pooled indices of several measures have been developed to assess and monitor patients with rheumatoid arthritis in clinical trials and clinical care, as no single measure can serve as a "gold standard" in all individual patients. Early indices of disease activity include the Steinbrocker "therapeutic scorecard in rheumatoid arthritis," the Lansbury Index, and Paulus criteria. The most widely used indices at this time are the American College of Rheumatology (ACR) Core Data Set and disease activity score (DAS). A simplified disease activity index (SDAI) and clinical disease activity index (CDAI) are derived from the DAS. The ACR Core Data Set includes 7 measures--swollen joint count, tender joint count, patient assessment of global status, an acute phase reactant [erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP)], health professional assessment of global status, physical function, and pain; the first four of these measures are included on the DAS. Improvement criteria for the ACR Core Data Set are based on improvement of at least 20% in both tender and swollen joint counts, and three of the five additional measures (ACR 20), and corresponding "ACR 50," and "ACR 70." A pooled index which includes only the three patient self-report questionnaire measures from the Core Data Set, physical function, pain, and patient assessment of global status performs as well as ACR 20 or DAS to discriminate between efficacy of active versus placebo treatment in a clinical trial.
班田法における「墾田」規定の再考察 : 日中律令制の比較研究をめぐって (2005)

はじめに / 第一章 律令田制と墾田 / 第一節 律令田制と墾田 / 第二節 墾田永年私財法と私的土地所有成立の契機 / 第二章 班田法と均田法の比較 / 第一節 官人永業田の規定と墾田永年私財法 / 第二節 班田法と均田法の法思想について / 第三章 日本律令国家の再考察 / 第一節 墾田永年私財法と律令収取方針の転換 / 第二節 律令法及び律令制の変容 /おわりに
Microparticles Engineered to Highly Express Peroxisome Proliferator-Activated Receptor-γ Decreased Inflammatory Mediator Production and Increased Adhesion of Recipient Monocytes (2014)

Circulating blood microparticles are submicron vesicles released primarily by megakaryocytes and platelets that act as transcellular communicators. Inflammatory conditions exhibit elevated blood microparticle numbers compared to healthy conditions. Direct functional consequences of microparticle composition, especially internal composition, on recipient cells are poorly understood. Our objective was to evaluate if microparticle composition could impact the function of recipient cells, particularly during inflammatory provocation. We therefore engineered the composition of megakaryocyte culture-derived microparticles to generate distinct microparticle populations that were given to human monocytes to assay for influences recipient cell function. Herein, we tested the responses of monocytes exposed to either control microparticles or microparticles that contain the anti-inflammatory transcription factor, peroxisome proliferator-activated receptor-γ (PPARγ). In order to normalize relative microparticle abundance from two microparticle populations, we implemented a novel approach that utilizes a Nanodrop Spectrophotometer to assay for microparticle density rather than concentration. We found that when given to peripheral blood mononuclear cells, microparticles were preferentially internalized by CD11b+ cells, and furthermore, microparticle composition had a profound functional impact on recipient monocytes. Specifically, microparticles containing PPARγ reduced activated monocyte production of the proinflammatory cytokines interleukin-8 and monocyte chemotactic protein-1 compared to activated monocytes exposed to control microparticles. Additionally, treatment with PPARγ microparticles greatly increased monocyte cell adherence. This change in morphology occurred simultaneously with increased production of the key extracellular matrix protein, fibronectin and increased expression of the fibronectin-binding integrin, ITGA5. PPARγ microparticles also changed monocyte mRNA levels of several genes including those under PPARγ control. Overall, the delivery of PPARγ from microparticles to human monocytes influenced gene expression, decreased inflammatory mediator production and increased monocyte adherence. These results support the concept that the composition of blood microparticles has a profound impact on the function of cells with which they interact, and likely plays a role in vascular inflammation.
Simultaneous detection of waterborne viruses by multiplex real-time PCR (2013)

Norovirus, Rotavirus group A, the Hepatitis A virus, and Coxsackievirus are all common causes of gastroenteritis. Conventional diagnoses of these causative agents are based on antigen detection and electron microscopy. To improve the diagnostic potential for viral gastroenteritis, internally controlled multiplex real-time polymerase chain reaction (PCR) methods have been recently developed. In this study, individual real-time PCRs were developed and optimized for specific detections of Norovirus genogroup I, Norovirus genogroup II, Rotavirus group A, the Hepatitis A virus, and Coxsackievirus group B1. Subsequently, individual PCRs were combined with multiplex PCR reactions. In general, multiplex real-time PCR assays showed comparable sensitivities and specificities with individual assays. A retrospective clinical evaluation showed increased pathogen detection in 29% of samples using conventional PCR methods. Prospective clinical evaluations were detected in 123 of the 227 (54%) total samples used in the multiplex real-time PCR analysis. The Norovirus genogroup II was found most frequently (23%), followed by Rotavirus (20%), the Hepatitis A virus (4.5%), Coxsackievirus (3.5%), and Norovirus genogroup I (2.6%). Internally controlled multiplex real-time PCR assays for the simultaneous detection of Rotavirus, Coxsackievirus group B, the Hepatitis A virus, and Norovirus genogroups I and II showed significant improvement in the diagnosis of viral gastroenteritis.
Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases (2020)

Skeletal muscle is an essential tissue that attaches to bones and facilitates body movements. Insulin-like growth factor-1 (IGF-1) is a hormone found in blood that plays an important role in skeletal myogenesis and is importantly associated with muscle mass entity, strength development, and degeneration and increases the proliferative capacity of muscle satellite cells (MSCs). IGF-1R is an IGF-1 receptor with a transmembrane location that activates PI3K/Akt signaling and possesses tyrosine kinase activity, and its expression is significant in terms of myoblast proliferation and normal muscle mass maintenance. IGF-1 synthesis is elevated in MSCs of injured muscles and stimulates MSCs proliferation and myogenic differentiation. Mechanical loading also affects skeletal muscle production by IGF-1, and low IGF-1 levels are associated with low handgrip strength and poor physical performance. IGF-1 is potentially useful in the management of Duchenne muscular dystrophy, muscle atrophy, and promotes neurite development. This review highlights the role of IGF-1 in skeletal muscle, its importance during myogenesis, and its involvement in different disease conditions.
0834 Coronary Stent (2010)

強度と柔軟性に優れ血管に優しい形状のプラットフォーム(JSTec-CoCr)に、安全性に優れたアルガトロバン(日本で開発された抗トロンビン剤)を生体吸収性ポリマーにてコートした、国産の冠状動脈用薬剤溶出ステント(JSTec-DES)の開発。