gebhart/patrepeval huggingface dataset:
Upregulation of fibroblast growth factors and their receptors during multi-stage epidermal carcinogenesis in K14-HPV16 transgenic mice. (1996)

Upregulation of acidic and basic fibroblast growth factors (FGF-1 and -2), and their cognate receptors FGFR-1 and -2, has been demonstrated in a variety of epithelial malignancies. However, the patterns of FGF/FGFR expression at specific stages of epithelial carcinogenesis have not been extensively characterized. In this report, the levels of FGF-1, FGF-2, FGF-7 mRNA and their receptors FGFR-1 and FGFR-2, were investigated during epidermal carcinogenesis in transgenic mice expressing the early region of the 'high risk' papillomavirus type 16 (HPV16) under control of the human keratin-14 enhancer/promoter (K14-HPV16 transgenic mice). FGF-1 was first upregulated in dysplasias, while FGF-2 was constitutively expressed in non-transgenic, neoplastic, and malignant keratinocytes throughout carcinogenesis. Expression of FGF-7 was undetectable in non-transgenic epidermis, and remained at threshold levels at all stages of progression. In well differentiated squamous cancers, FGFR-1 was upregulated and co-localized with angiogenic capillaries in the dermis underlying dysplastic lesions and within papillary fronds of invasive cancers. In contrast, FGFR-1 was upregulated specifically within the malignant squamous cells of moderate-poorly differentiated squamous cancers. The expression of FGFR-2 was essentially constitutive in both non-transgenic and neoplastic epidermis. Collectively the data suggest that the FGF/FGFR signaling pathways may potentially contribute to several facets of multi-stage epithelial carcinogenesis, including auto- or paracrine growth stimulation, upregulation of angiogenesis, and stromal remodeling.
Modeling the performance of HTTP over several transport protocols (1997)

This paper considers the interaction of HTTP with several transport protocols, including TCP, Transaction TCP, a UDP-based request-response protocol, and HTTP with persistent TCP connections. We present an analytic model for each of these protocols and use that model to evaluate network overhead carrying HTTP traffic across a variety of network characteristics. This model includes an analysis of the transient effects of TCP slow-start. We validate this model by comparing it to network packet traces measured with two protocols (HTTP and persistent HTTP) over local and wide-area networks. We show that the model is accurate within 5% of measured performance for wide-area networks, but can underestimate latency when the bandwidth is high and delay is low. We use the model to compare the connection-setup costs of these protocols, bounding the possible performance improvement. We evaluate these costs for a range of network characteristics, finding that setup optimizations are relatively unimportant for current modem, ISDN, and LAN users but can provide moderate to substantial performance improvement over high-speed WANs. We also use the model to predict performance over future network characteristics.
ChemInform Abstract: Magnetic Properties of Ho(Fe1‐xNix)11.3Nb0.7 Compounds. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Limbic Activation Associated With Misidentification of Fearful Faces and Flat Affect in Schizophrenia (2007)

Abnormal amygdala activation in schizophrenia in response to presentation of fearful faces is paradoxically associated with failure to recognize the emotion and with more severe flat affect. This finding suggests that flat affect in schizophrenia relates to overstimulation of the limbic system.
Real time data acquisition: experience with the Medical Information Bus (MIB). (1991)

Care of the acutely ill patient requires rapid acquisition, recording and communications of data. In the modern hospital it is not unusual for a patient to be connected to several monitoring and recording devices simultaneously. Each of these devices is typically made by a different manufacturer who may specialize in one sort of measurement, for example, pulse oximetry. Most of the modern monitoring and recording devices are micro-processor based and have communications capabilities. Unfortunately, there is no operable standard communications technology available from all devices. In addition different clinical staff (physicians, nurses, or respiratory therapists) may be responsible for collecting data. As a result there is a need to develop methods, standards, and strategies for timely and automatic collection of data from these monitoring and recording devices. We report on more than 5 years of clinical experience of automated ICU data collection using a prototype of the Medical Information Bus (MIB).
Cationic Polymerization of Electron-Donor Monomers by 1,1,2,2-Tetracyanocyclopropylstyrene, A New Electron-Acceptor (1991)

Poly (N-vinylcarbazole) was obtained spontaneously by 1,1,2,2-tetracyanocyclopropylstyrene(1) in polar solvents such as dichloromethane and acetonitrile at room temperature. The polymerization reactions were faster in more polar solvent and were not proceeded in less polar solvents such as chloroform and diethyl ether. The formation of poly (N-vinylcarbazole) was explained by bond-forming initiation theory, in which the initiating species are zwitterionic tetramethylene intermediates.
Adaptive Run-Length / Golomb-Rice Encoding of Quantized Generalized Gaussian Sources with Unknown Statistics (2006)

We present a simple and efficient entropy coder that combines run-length and Golomb-Rice encoders. The encoder automatically switches between the two modes according to simple rules that adjust the encoding parameters based on the previous output codeword, and the decoder tracks such changes. This adaptive run-length/Golomb-Rice (RLGR) coder has a fast learning rate, making it suitable for many practical applications, which usually involve encoding small source blocks. We study the encoding of generalized Gaussian (GG) sources after quantization with uniform scalar quantizers with deadzone, which are good source models in multimedia data compression, for example. We show that, for a wide range of source parameters, the RLGR encoder has a performance close to that of the optimal Golomb-Rice and exp-Golomb coders designed with knowledge of the source statistics, and in some cases the RLGR coder improves coding efficiency by 20% or more.
Effects of attractive versus repulsive vibrotactile instructional cues during motion replication tasks (2011)

The Mobile Instrument for Motion Instruction and Correction (MIMIC) enables an expert (i.e., physical therapist) to map his/her movements to a trainee (i.e., patient) in a hands-free fashion. MIMIC comprises an Expert Module (EM) and a Trainee Module (TM); both modules include six-degree-of-freedom inertial measurement units, microcontrollers, and batteries. The TM also includes actuators that provide the trainee with vibrotactile instructional cues. The estimated expert body motion information is transmitted wirelessly to the trainee; based on the computed difference between the motions of the expert and trainee, directional instructions are displayed to the trainee's skin via vibrotactile stimulation. This study examined anterior-posterior trunk movements using a simplified version of the MIMIC system in which only two actuators were used to provide feedback and pre-recorded target trajectories were used to represent ideal expert movements. The study was designed to investigate the effects of attractive versus repulsive vibrotactile instructional cues when the motion speed and task complexity were varied. Preliminary results (n = 12) suggest that repulsive vibrotactile instructional cues lead to the greatest correlation between expert and subject motion, the least time delay, and the least tilt error.
Buoyancy-based Rapid Prototyping of Lenses (2020)

Current methods for fabricating lenses rely on mechanical processing of the lens or mold, such as grinding, machining and polishing. The complexity of these fabrication processes and the required specialized equipment prohibit rapid prototyping of optical components. This work presents a simple method that leverages the basic physics of surface tension and hydrostatics for rapidly fabricating a variety of lenses with optical surface quality and without the need for any mechanical processing. This approach allows to fabricate all types of spherical lenses(positive, negative, meniscus)over a wide range of sizes and curvatures, as well as lenses of special structure and topography(aspherical, saddle, bi-focal, doublet). The method is inexpensive, does not require specialized equipment, and can be implemented using a variety of curable liquids.
Maximum Likelihood Wavelet Density Estimation With Applications to Image and Shape Matching (2008)

Density estimation for observational data plays an integral role in a broad spectrum of applications, e.g., statistical data analysis and information-theoretic image registration. Of late, wavelet-based density estimators have gained in popularity due to their ability to approximate a large class of functions, adapting well to difficult situations such as when densities exhibit abrupt changes. The decision to work with wavelet density estimators brings along with it theoretical considerations (e.g., non-negativity, integrability) and empirical issues (e.g., computation of basis coefficients) that must be addressed in order to obtain a bona fide density. In this paper, we present a new method to accurately estimate a non-negative density which directly addresses many of the problems in practical wavelet density estimation. We cast the estimation procedure in a maximum likelihood framework which estimates the square root of the density radicalp, allowing us to obtain the natural non-negative density representation ( radicalp)(2). Analysis of this method will bring to light a remarkable theoretical connection with the Fisher information of the density and, consequently, lead to an efficient constrained optimization procedure to estimate the wavelet coefficients. We illustrate the effectiveness of the algorithm by evaluating its performance on mutual information-based image registration, shape point set alignment, and empirical comparisons to known densities. The present method is also compared to fixed and variable bandwidth kernel density estimators.
Structural basis of bacteriophage T5 infection trigger and E. coli cell wall perforation (2022)

Abstract The vast majority of bacteriophages (phages) - bacterial viruses - present a tail that allows host recognition, cell wall perforation and safe channelling of the viral DNA from the capsid to the cytoplasm of the infected bacterium. The majority of tailed phages bears a long flexible tail ( Siphoviridae ) at the distal end of which a tip complex, often called baseplate, harbours one or more Receptor Binding Protein·s (RBPs). Interaction between the RBPs and the host surface triggers cell wall perforation and DNA ejection, but little is known on these mechanisms for Siphoviridae . Here, we present the structure of siphophage T5 tip at high resolution, determined by electron cryo-microscopy, allowing to trace most of its constituting proteins, including 35 C-terminal residues of the Tape Measure Protein. We also present the structure of T5 tip after interaction with its E. coli receptor FhuA reconstituted into nanodisc. It brings out the dramatic conformational changes underwent by T5 tip upon infection, i . e . bending of the central fibre on the side, opening of the tail tube and its anchoring to the membrane, and formation of a transmembrane channel. These new structures shed light on the mechanisms of host recognition and activation of the viral entry for Siphoviridae .
The B subfamily of plant ATP binding cassette transporters and their roles in auxin transport (2014)

The ATP binding cassette B/multidrug-resistance/P-glycoprotein (ABCB/MDR/PGP) subfamily is a member of the ABC protein family. Significant progress has been made in the functional characterization of ABCB genes, particularly in Arabidopsis thaliana. This review evaluates recent advances concerning the plant ABCB subfamilies including their evolution and structure, the involvement and regulation of ABCB-mediated auxin transport, and the roles of ABCBs in plant growth and development. Insights into specific functions of members of the ABCB subfamily and their mediation of various regulatory pathways are also presented.
ALUMINUM HYDRIDE DERIVATIVES FROM THE REACTIONS OF LITHIUM ALUMINUM HYDRIDE WITH TRIMETHYLAMINE AND DIMETHYLAMINE (1964)

not available
Helicobacter pylori Lipopolysaccharides Upregulate Toll-Like Receptor 4 Expression and Proliferation of Gastric Epithelial Cells via the MEK1/2-ERK1/2 Mitogen-Activated Protein Kinase Pathway (2009)

Helicobacter pylori is recognized as an etiological agent of gastroduodenal diseases. H. pylori produces various toxic substances, including lipopolysaccharide (LPS). However, H. pylori LPS exhibits extremely weakly endotoxic activity compared to the typical LPS, such as that produced by Escherichia coli, which acts through Toll-like receptor 4 (TLR4) to induce inflammatory molecules. The gastric epithelial cell lines MKN28 and MKN45 express TLR4 at very low levels, so they show very weak interleukin-8 (IL-8) production in response to E. coli LPS, but pretreatment with H. pylori LPS markedly enhanced IL-8 production induced by E. coli LPS by upregulating TLR4 via TLR2 and the MEK1/2-ERK1/2 pathway. The transcription factor NF-Y was activated by this signal and promoted transcription of the tlr4 gene. These MEK1/2-ERK1/2 signal-mediated activities were more potently activated by LPS carrying a weakly antigenic epitope, which is frequently found in gastric cancers, than by LPS carrying a highly antigenic epitope, which is associated with chronic gastritis. H. pylori LPS also augmented the proliferation rate of gastric epithelial cells via the MEK1/2-ERK1/2 pathway. H. pylori LPS may be a pathogenic factor causing gastric tumors by enhancing cell proliferation and inflammation via the MEK1/2-ERK1/2 mitogen-activated protein kinase cascade in gastric epithelial cells.
Wireless Data Technologies (2003)

From the Publisher:
The expansion and popularity of the Internet, along with the addition of wireless data functionality to wireless networks, has also contributed greatly to the growth of the wireless industry. In fact, the anticipated consumer demand for high bandwidth wireless data is commonly seen as the driving force behind current network upgrades and expansions. The number and types of companies aggressively investing in wireless technologies illustrate the importance of wireless data. Non-traditional telecommunications companies such as Cisco Systems, Intel, Microsoft, 3Com, and other professional services companies, are investing heavily in wireless product development and many have formed partnerships with wireless infrastructure manufacturers to help deliver wireless data services seamlessly to consumers.
Written by a respected author this self-contained overview of wireless date technologies will provide a highly sought after technical reference to all those working within the main areas of Wireless Data Services.
Provides a self-contained reference which discusses the key wireless technologies including securityPresents an overview of the wireless industry and its key components such as GSM, GPRS, CDMA, TDMA, UMTS, cdma2000, and Spread Spectrum, 802.11, 15 and 16 standardsDiscusses the currently hot topic of Wireless SecurityIncludes a Foreword by Dr Bill Hancock, Chief Security Officer, Exodus Communications/Cable & WirelessProvides a ready reference as well as a reference to additional materials on each topic
Essential reading for all staff working for Telecom companies: engineers, researchers, managers etc.
Structural and Biochemical Analysis of the Phosphate Donor Specificity of the Polynucleotide Kinase Component of the Bacterial Pnkp•Hen1 RNA Repair System (2013)

Clostridium thermocellum Pnkp is the end-healing and end-sealing subunit of a bacterial RNA repair system. CthPnkp is composed of three catalytic modules: an N-terminal 5'-OH polynucleotide kinase, a central 2',3' phosphatase, and a C-terminal ligase. The crystal structure of the kinase domain bound to ATP•Mg(2+) revealed a rich network of ionic and hydrogen-bonding contacts to the α, β, and γ phosphates. By contrast, there are no enzymic contacts to the ribose and none with the adenine base other than a π-cation interaction with Arg116. Here we report that the enzyme uses ATP, GTP, CTP, UTP, or dATP as a phosphate donor for the 5'-OH kinase reaction. The enzyme also catalyzes the reverse reaction, in which a polynucleotide 5'-PO4 group is transferred to ADP, GDP, CDP, UDP, or dADP to form the corresponding NTP. We report new crystal structures of the kinase in complexes with GTP, CTP, UTP, and dATP in which the respective nucleobases are stacked on Arg116 but make no other enzymic contacts. Mutating Arg116 to alanine elicits a 10-fold increase in Km for ATP but has little effect on kcat. These findings illuminate the basis for nonspecific donor nucleotide utilization by a P-loop phosphotransferase.
Virtual Hip Joint: from Computer Graphics to Computer-Assisted Diagnosis (2009)

Osteoarthritis (OA) is a major musculoskeletal disorder which causes are not always fully understood. Femoroacetabular impingements such as cam/ pincer cannot always explain observed OA in hips with normal morphology. This paper investigates the hypothesis of extreme repetitive movements as a source of cartilage degeneration. We present a clinical study conducted with professional ballet dancers and a methodology to perform functional simulations of the hip joint in extreme postures. Throughout the process, various computer graphics techniques are used, like motion capture, 3D body scanning and physically-based models. In addition to accelerate and strengthen some tasks, these techniques strongly participate in the clinical understanding of OA related to motion. Preliminary results have indeed shown a significant correlation between the location of impingements and radiologically observed damage zones in the labrum cartilage.
Virus-like Particle and Viral Vector Production Using the Baculovirus Expression Vector System/Insect Cell System (2007)

The ability to make a large variety of virus-like particles (VLPs) has been successfully achieved in the baculovirus expression vector system (BEVS)/insect cell system. The production and scale-up of these particles, which are mostly sought as candidate vaccines, are currently being addressed. Furthermore, these VLPs are being investigated as delivery agents for use as therapeutics. Recently, adeno-associated viral (AAV) vectors, which can be potentially used for human gene therapy, have been produced in insect cells using three baculovirus vectors to supply the required genes. The use of host insect cells allows mass production of VLPs in a proven scaleable system. This chapter focuses on the methodology, based on the work done in our lab, for the production of AAV-like particles and vectors in a BEVS/insect cell system.
The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation (1987)

Previous studies showed that the amino-terminal domain of Rous sarcoma virus p60v-src involved in myristylation and membrane association of the protein is required for morphological transformation and anchorage independence. Analysis of src delection mutants revealed that the amino-terminal one-third of p60v-src, including the membrane-binding domain, is not essential for induction of cell proliferation. These results demonstrated that, in contrast to the cellular target(s) involved in morphological transformation and anchorage independence, the target(s) involved in mitogenic activity is accessible to nonmyristylated src proteins.
Tissue culture-induced DNA methylation variation in maize. (1993)

Twenty-one progeny lines derived from tissue cultures of two embryo sources of maize inbred strain A188 were examined for DNA methylation changes. Total DNA was cut with the isoschizomers Hpa II and Msp I and probed with 18 single-copy Pst I genomic clones and two cDNA clones. Eight of these probes could detect both increases and decreases in methylation. With these probes 39% of the families were found to contain an altered methylation pattern. All changes represented a decrease in methylation. The other 12 probes could detect only increases in methylation; no methylation variation was seen with these probes. Fifteen percent of the methylation changes were homozygous in the original regenerated plant. Changes were stably inherited upon two generations of self-pollination. No sequence variation was observed in Msp I-digested DNA from the same 21 progeny lines. Certain probes detected methylation changes much more often than others. Our study provides evidence that demethylation occurs at a high frequency and could be an important cause of tissue culture-induced variation. Occurrence of the frequent homozygous alterations in original regenerated plants implies a non-random mutational mechanism.
Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events (2006)

The relationship between autoantibodies to oxidized low density lipoprotein (OxLDL) and coronary artery disease (CAD) remains controversial. IgM and IgG OxLDL autoantibodies to malondialdehyde (MDA)-modified LDL, copper oxidized low density lipoprotein (CuOxLDL), and oxidized cholesterol linoleate (OxCL), as well as apolipoprotein B-100 immune complexes (apoB-ICs), were measured in 504 patients undergoing clinically indicated coronary angiography. Patients were followed for cardiovascular events for a median of 4 years. In univariate analysis, IgM OxLDL autoantibodies and IgM apoB-ICs were inversely associated with the presence of angiographically determined CAD, whereas IgG OxLDL autoantibodies and IgG apoB-ICs were positively associated. In logistic regression analysis, compared with the first quartile, patients in the fourth quartile of IgM OxLDL autoantibodies and apoB-ICs showed a lower probability of angiographically determined CAD (>50% diameter stenosis). Odds ratios and (95% confidence intervals) were as follows: MDA-LDL, 0.51 (0.32-0.82; P = 0.005); CuOxLDL, 0.63 (0.39-1.01; P = 0.05); OxCL, 0.63 (0.39-1.01; P = 0.05); and apoB-IC, 0.55 (0.34-0.88; P = 0.013). These relationships were accentuated in the setting of hypercholesterolemia, with the highest IgM levels showing the lowest risk of CAD for the same level of hypercholesterolemia. Multivariable analysis revealed that neither IgM or IgG OxLDL autoantibodies nor apoB-ICs were independently associated with angiographically determined CAD or cardiovascular events. In conclusion, IgG and IgM OxLDL biomarkers have divergent associations with CAD in univariate analysis but are not independent predictors of CAD or clinical events.