gebhart/patrepeval huggingface dataset:
Anti-fatigue effects of porcine placenta and its amino acids in a behavioral test on mice (2014)

Placenta extracts are used for their health benefits; however, the anti-fatigue effects of placenta have not been elucidated. Thus, we investigated the anti-fatigue effects of porcine placenta extract (PE) and the amino acids present in the PE (glycine, Gly; proline, Pro; glutamic acid, GA; and arginine, Arg) using a forced swimming test (FST) and a tail-suspension test (TST) on mice. Whole PE or individual amino acids decreased immobility times in the FST. PE, Pro, and Arg all lowered blood levels of lactic acid and alanine aminotransferase (ALT). PE and Gly improved glycogen content and catalase activity. As determined from the serum after the FST: PE regulated the effects of interferon (IFN)-γ and tumor necrosis factor (TNF)-α; GA regulated the effects of IFN-γ; Gly and Arg regulated the effects of interleukin (IL)-6; and all of the amino acids present in PE regulated the effects of TNF-α. As determined from the spleen after the FST: Gly and Arg regulated the effects of IL-1β; Gly, Pro, and Arg regulated the effects of IL-6; PE and all of the amino acids present in PE regulated the effects of TNF-α. After the TST, PE and all of the amino acids present in PE reduced immobility duration as well as levels of aspartate aminotransferase and ALT. As determined from the serum after the TST: PE and Gly regulated the effects of TNF-α; Gly and Arg regulated the effects of IL-1β; Gly, Pro, and Arg regulated the effects of IL-6; PE and all of the amino acids present in PE regulated the effects of TNF-α. These results suggest that PE should be considered a candidate anti-fatigue agent.
Latent Heat Storage for Solar Steam Systems (2007)

Solar thermal systems, including direct steam generation in the absorbers, require isothermal energy storage systems. One option to fulfil this requirement is the application of phase change materials (PCMs) to absorb or release energy. The implementation of cost-effective storage systems demands the compensation of the low thermal heat conductivity that is characteristic for the candidate materials for PCM. Solar steam generation for power plants requires latent heat storage systems for a saturation temperature range between 200°C and 320°C. This paper describes the basic concepts investigated and first results of research activities aiming at the demonstration of a storage system using steam provided by parabolic trough collectors.
N- and C-terminal Domains Direct Cell Type-specific Sorting of Chromogranin A to Secretory Granules (2000)

Chromogranins are a family of regulated secretory proteins that are stored in secretory granules in endocrine and neuroendocrine cells and released in response to extracellular stimulation (regulated secretion). A conserved N-terminal disulfide bond is necessary for sorting of chromogranins in neuroendocrine PC12 cells. Surprisingly, this disulfide bond is not necessary for sorting of chromogranins in endocrine GH4C1 cells. To investigate the sorting mechanism in GH4C1 cells, we made several mutant forms removing highly conserved N- and C-terminal regions of bovine chromogranin A. Removing the conserved N-terminal disulfide bond and the conserved C-terminal dimerization and tetramerization domain did not affect the sorting of chromogranin A to the regulated secretory pathway. In contrast, removing the C-terminal 90 amino acids of chromogranin A caused rerouting to the constitutive secretory pathway and impaired aggregation properties as compared with wild-type chromogranin A. Since this mutant was sorted to the regulated secretory pathway in PC12 cells, these results demonstrate that chromogranins contain independent N- and C-terminal sorting domains that function in a cell type-specific manner. Moreover, this is the first evidence that low pH/calcium-induced aggregation is necessary for sorting of a chromogranin to the regulated secretory pathway of endocrine cells.
Polycystic ovaries in non-obese and obese patients: possible pathophysiological mechanism based on new interpretation of facts and findings (1993)

This study was designed to investigate the basic concentrations of different hormones in obese and non-obese patients with polycystic ovarian disease (PCOD). Eight women with PCOD, of whom four were obese with body mass index (BMI, kg/m2) of > 25 and four were non-obese with BMI < 25, volunteered to participate in this study. Serum samples were taken every 20 min over an 8 h period, starting at 2300 h, on day 5 of a spontaneous or gestagen-induced cycle. Basic insulin concentration was found to be significantly higher in the obese women compared with their non-obese counterparts (P < 0.0001). Serum concentrations of insulin-like growth factor binding protein (IGFBP-I) and sex hormone binding globulin (SHBG) were found to be significantly lower (P < 0.001 for both hormones) in the obese compared with the non-obese women. Serum concentrations of insulin-like growth factor I (IGF-I) did not differ between the two groups. The non-obese women had significantly higher serum concentrations of luteinizing hormone (LH) (P < 0.001) and of growth hormone (GH) (P < 0.002) than their obese counterparts. Based on these results, two models of the development of PCOD were suggested. In obese women, hyperinsulinaemia causes an excessive production of androgens through the enhancement of IGF-I receptors which, in synergism with LH, causes increased activity of cytochrome P-450c 17a. In non-obese patients, relative increase of GH concentration stimulates excessive ovarian IGF-I production. At this point synergism with LH results in excessive production of androgens by the same mechanism as in obese patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Head-related transfer function interpolation in azimuth, elevation, and distance (2013)

Although distance-dependent head-related transfer function (HRTF) databases provide interesting possibilities, e.g., for rendering virtual sounds in the near-field, there is a lack of algorithms and tools to make use of them. Here, a framework is proposed for interpolating HRTF measurements in 3-D (i.e., azimuth, elevation, and distance) using tetrahedral interpolation with barycentric weights. For interpolation, a tetrahedral mesh is generated via Delaunay triangulation and searched via an adjacency walk, making the framework robust with respect to irregularly positioned HRTF measurements and computationally efficient. An objective evaluation of the proposed framework indicates good accordance between measured and interpolated near-field HRTFs.
Advances in the Use of Regulatory T-Cells for the Prevention and Therapy of Graft-vs.-Host Disease (2017)

Regulatory T (Tregs) cells play a crucial role in immunoregulation and promotion of immunological tolerance. Adoptive transfer of these cells has therefore been of interest in the field of bone marrow and solid organ transplantation, autoimmune diseases and allergy medicine. In bone marrow transplantation, Tregs play a pivotal role in the prevention of graft-verus-host disease (GvHD). This has generated interest in using adoptive Treg cellular therapy in the prevention and treatment of GvHD. There have been several barriers to the feasibility of Treg cellular therapy in the setting of hematopoietic stem cell transplantation (HSCT) which include low Treg concentration in peripheral blood, requiring expansion of the Treg population; instability of the expanded product with loss of FoxP3 expression; and issues related to the purity of the expanded product. Despite these challenges, investigators have been able to successfully expand these cells both in vivo and in vitro and have demonstrated that they can be safely infused in humans for the prevention and treatment of GvHD with no increase in relapse risk or infections risk.
Design of Self-Coded Combinatorial Libraries To Facilitate Direct Analysis of Ligands by Mass Spectrometry (1998)

The direct analysis of selected components from combinatorial libraries by sensitive methods such as mass spectrometry is potentially more efficient than deconvolution and tagging strategies since additional steps of resynthesis or introduction of molecular tags are avoided. A substituent selection procedure is described that eliminates the mass degeneracy commonly observed in libraries prepared by "split-and-mix" methods, without recourse to high-resolution mass measurements. A set of simple rules guides the choice of substituents such that all components of the library have unique nominal masses. Additional rules extend the scope by ensuring that characteristic isotopic mass patterns distinguish isobaric components. The method is applicable to libraries having from two to four varying substituent groups and can encode from a few hundred to several thousand components. No restrictions are imposed on the manner in which the "self-coded" library is synthesized or screened.
Electroencephalography/functional magnetic resonance imaging responses help predict surgical outcome in focal epilepsy (2013)

This study demonstrates that hemodynamic responses related to epileptic activity can help delineate the epileptogenic region. Full concordance between maximum response and surgical resection is indicative of seizure freedom, whereas a resection leaving the maximum response intact is likely to lead to a poor outcome. EEG/fMRI is noninvasive but is limited to patients in whom interictal epileptic discharges can be recorded during the 60-90 min scan.
Suppression of subcutaneous oxidation during the deposition of amorphous lanthanum aluminate on silicon (2004)

Amorphous LaAlO3 thin films have been deposited by molecular beam deposition directly on silicon without detectable oxidation of the underlying substrate. We have studied these abrupt interfaces by Auger electron spectroscopy, high-resolution transmission electron microscopy, medium-energy ion scattering, transmission infrared absorption spectroscopy, and x-ray photoelectron spectroscopy. Together these techniques indicate that the films are fully oxidized and have less than 0.2 Å of SiO2 at the interface between the amorphous LaAlO3 and silicon. These heterostructures are being investigated for alternative gate dielectric applications and provide an opportunity to control the interface between the silicon and the gate dielectric.
Effects of Mechanical Pressure on the Tangent Delta of MV Cable Joints (2019)

Medium-voltage cable joints are one of the critical components of the distribution networks. They represent the first cause of faults and outages. Among the others, partial discharge, dielectric, and temperature measurements are the typical tests performed for investigating over the early aging of such critical components. In this paper, a new study has been completed correlating the cable joint tangent delta (Tanδ ) value to the external pressure applied on the insulating material surrounding the joint. Results confirm the presumed correlation. In fact, an increase of pressure results in a Tanδ decrease, hence in an extension of the cable joint working life.
Improvement of the cooling performance of a reciprocating compressor cylinder by a conjugate heat transfer and deformation analysis (2014)

The cooling system of a reciprocating compressor has a big impact on the total cost of the unit, depending on the total head and the capacity of the system. Considering that current regulations API618 for reciprocating compressor impose the refrigeration of the cylinder, cooling water passages inside cylinder shall be designed to limit as much as possible thermal dilatation and to avoid hot spots, while lowering down capacity and pressure losses.&#13;\nIn this paper, a conjugate heat transfer (CHT) analysis on a double-acting water-cooled reciprocating compressor cylinder is presented. The aim of the study was the simulation of simultaneous heat transfer in both the solid metal and the water circuit, where the conduction in the solid and the convection in the fluid are analysed concurrently. A detailed overview on some critical issues for the assessment of the proper boundary conditions for the metal body is given. &#13;\nTwo different geometrical configurations of the refrigerating system were studied in order to improve the cooling performance. Moreover, a thermal deformation analysis to check the induced dilatations was carried out. Finally, the most suitable geometrical layout was assessed and a sensitivity analysis was performed on the influence of the mass flow rate on the cooling efficiency.
Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines (2022)

Antimicrobial drug resistance is a looming health crisis facing us in the modern era, and new drugs are urgently needed to combat this growing problem. Synthetic mimics of antimicrobial peptides have recently emerged as a promising class of compounds for the treatment of persistent microbial infections. In the current study, we investigate five cyclic <i>N</i>-alkylated amphiphilic 2,5-diketopiperazines against 15 different strains of bacteria and fungi, including drug-resistant clinical isolates. Several of the 2,5-diketopiperazines displayed activities similar or superior to antibiotics currently in clinical use, with activities coupled to both the cationic and hydrophobic substituents. All possible stereoisomers of the lead peptide were prepared, and the effects of stereochemistry and amphiphilicity were investigated via 1D and 2D NMR spectroscopy, solution dynamics, and membrane interaction modeling. Clear differences in solution structures and membrane interaction potentials explain the differences seen in the bioactivity and physicochemical properties of each stereoisomer.
ChemInform Abstract: Synthesis of (E)‐ and (Z)‐α‐Alkylidene‐γ‐aryl‐γ‐butyrolactones via Alkenylalumination of Oxiranes. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ein neuer Faktor im Kampf des Lebens um Energie (2011)

Ein Bakterium sieht rot: Chlorophyll f (Chl f) ist ein in Cyanobakterien entdecktes Tetrapyrrol mit beispiellos rotverschobenen Absorptionsbanden. Seine Struktur wurde spektroskopisch abgeleitet. Sein Chromophor dürfte ein Resultat der biologischen Adaption der Bakterien und der biochemischen Optimierung in ihrem Überlebenskampf sein und ist auch ein Zeichen für den stetigen Bedarf des Lebens an Energie, die durch die Photosynthese gewonnen wird.
High-temperature thermoelectric properties of (Zn1−xAlx)O (1996)

A mixed oxide (Zn1−xAlx)O exhibits promising thermoelectric properties attaining a dimensionless figure of merit ZT of 0.30 at 1000 °C, which value is much superior to other oxides and quite comparable to conventional state-of-the-art thermoelectric materials. The addition of a small amount of Al2O3 to ZnO results in a large power factor of 10–15×10−4 W/mK2, showing a marked increase in the electrical conductivity while retaining moderate thermoelectric power. A large product of the carrier mobility and density of states would be responsible for the favorable electrical properties of the present oxide. A figure of merit Z=0.24×10−3 K−1 is attained by (Zn0.98Al0.02)O at 1000 °C, even with a high thermal conductivity. A predominant proportion of the phonon thermal conductivity promises a further improvement in the thermoelectric performance by selective enhancement of phonon scattering.
Cops on Trial: Did Fourth Amendment Case Law Help George Zimmerman's Claim of Self-Defense? (2016)

When police kill unarmed civilians, prosecutors and grand juries often decline to bring criminal charges. Even when police officers are indicted, they are seldom convicted at trial. There are many reasons why police are rarely convicted for violent acts. Commentators have criticized the inherent conflict of interest for prosecutors who decide whether to bring charges and the fact that police are investigating their own. However, this article considers another way that police may be treated differently than other people suspected of committing violent crimes. The Fourth Amendment, designed to protect civilians from overzealous officers, now helps insulate police suspected of committing violent crimes.
Dispersion and Reservoir Heterogeneity (1988)

Summary Macroscopic dispersion is the mixing, on the scale of several hundreds of grain diameters, at a point in a permeable medium that is free of boundary effects. Megascopic dispersion is the one-dimensional (1D) dispersion derived by averaging across an entire cross section. This work investigates how both dispersions vary with heterogeneity, aspect ratio, diffusion coefficient, and autocorrelation. The theoretical results are compared to existing field and laboratory data and to existing theories for limiting cases. The degree of autocorrelation in the medium determines whether or not megascopic dispersivity (dispersion coefficient divided by velocity) is uniquely defined. Large correlation distances (with respect to the medium dimensions) imply a dispersivity that grows with distance traveled. Small correlation distances imply a dispersivity that is eventually stabilized at some constant value. This value is related to the heterogeneity of the medium. On the field scale, diffusion is insignificant, but on a laboratory scale, it can stabilize the dispersivity even if the medium is correlated. Macroscopic dispersivity is sensitive to diffusion in both the laboratory and field scale. It is smaller than or equal to megascopic dispersivity, also in conformance with experimental data, and comparable to laboratory-measured dispersivity.
Delta9‐tetrahydrocannabinol and cannabidiol as potential curative agents for cancer: A critical examination of the preclinical literature (2015)

An Internet search with search words "cannabis cures cancer" produce a wealth of sites claiming that cannabis has this effect. These sites are freely accessible to the general public and thus contribute to public opinion. But do delta(9) -tetrahydrocannabinol (Δ(9) -THC) and cannabidiol (CBD) cure cancer? In the absence of clinical data other than a safety study and case reports, preclinical data should be evaluated in terms of its predictive value. Using a strict approach where only concentrations and/or models relevant to the clinical situation are considered, the current preclinical data do not yet provide robust evidence that systemically administered Δ(9) -THC will be useful for the curative treatment of cancer. There is more support for an intratumoral route of administration of higher doses of Δ(9) -THC. CBD produces effects in relevant concentrations and models, although more data are needed concerning its use in conjunction with other treatment strategies.
The role of BDNF in mediating the prophylactic effects of (R,S)-ketamine on fear generalization and extinction (2022)

Fear generalization is a conserved survival mechanism that can become maladaptive in the face of traumatic situations, a feature central to certain anxiety disorders including posttraumatic stress disorder (PTSD). However, the neural circuitry and molecular mechanisms underlying fear generalization remain unclear. Recent studies have shown that prophylactic treatment with (R,S)-ketamine confers protective effects in stress-induced depressive behaviors and enhances contextual fear discrimination, but the extent to which these effects extend to fear generalization after auditory fear conditioning remains unclear. Here, we build on this work by using a behavioral model of fear generalization in mice involving foot shocks with differential intensity levels during auditory fear conditioning. We find that prophylactic (R,S)-ketamine treatment exerts protective effects that results in enhanced fear discrimination in wild type mice. As the growth factor, brain-derived neurotrophic factor (BDNF), has been shown to mediate the rapid antidepressant actions of (R,S)-ketamine, we used a loss-of-function BDNF mouse line (BDNF Val66Met) to determine whether BDNF is involved in (R,S)-ketamine's prophylactic effects on fear generalization. We found that BDNF Val66Met mice were resistant to the protective effects of prophylactic (R,S)-ketamine administration on fear generalization and extinction. We then used fiber photometry to parse out underlying neural activity and found that in the ventral hippocampus there were significant fear generalization-dependent patterns of activity for wild type and BDNF Val66Met mice that were altered by prophylactic (R,S)-ketamine treatment. Overall, these findings indicate a role for the ventral hippocampus and BDNF signaling in modulating the mitigating effects of prophylactic (R,S)-ketamine treatment on generalized fear.
Channel-Length Impact on Supercoupling Effect in FD-MOSFETs (2014)

session SOI MOSFET Modelling
Malignant Histiocytosis with Multiple Skin Lesions in a Dog. (1993)

A 7-year-old male Yorkshire terrier was examined for multiple plaques and nodules on the skin. The clinical, cytological and histopathological features indicated a malignant histiocytosis. Cytoreductive chemotherapy produced moderate clinical improvement, but died at day 90 after the first admission. Pathological examination revealed the neoplastic histiocytes in the skin as well as in the myocardium and skeletal muscles.
Examination of member behaviors, group processes, and development-shaping forces of virtual learning teams (2003)

This study examined member behaviors, group processes, and development-shaping forces in order to identify group development processes/patterns of virtual learning teams. Participants of this study were seven newly formed virtual learning teams working on a final group project in a twelve-week online graduate-level course. All of the thirty three participants were full time Human Resource Development (HRD) professionals. In order to enhance the accuracy of the findings, this study corroborated findings from different data sources. 
Examining the frequency of all observed behaviors showed that completing task was the most frequently performed (59.3%), followed by building relationships among the team members (26.3%) and managing the team (14.4%). At the beginning, the social domain explained the largest proportion of observed behaviors, however, as team members started gathering necessary information for the project and sharing individuals' work progress, the work domain later became the dominant focus of performed behaviors. 
Examining the group processes of each team and the distribution of observed behaviors found two emerged group development patterns in virtual learning teams, Linear Progression and Adaptive Progression . Linear progression teams followed the linear sequence of orientation, scheduling, exploration, work and decision, progress check and evaluation, refinement and formatting, and termination. The initial group development of adaptive progression teams was the same as that of linear progression teams until the progress check and evaluation phase. However, adaptive progression teams found the evaluation of work progress or the outcome of group work was not satisfactory for team members. Those teams made an adaptation to the team progress by revisiting one or more of the previous phases based upon needs identified to finish the project. 
Examining development-shaping forces indicated that member-related characteristics were the primary underlying cause to the successful development of groups, but without being transformed into group norms, such as sharing work procedures, sharing individual members' work, discussing members' views and drawing group consensus, and identifying further actions to advance the work, the impact of individual characteristics on group development was minimal. This study concluded with recommendations for virtual learning team members and facilitators to address those development shaping forces within the temporal timeline.