gebhart/patrepeval huggingface dataset:
Shell design and reaming technique affect deformation in mobile-bearing total hip arthroplasty acetabular components (2017)

Press-fit acetabular components are susceptible to rim deformation. The inherent variability within acetabular reaming techniques may generate increased press-fit and, subsequently, additional component deformation. The purpose of this study was to analyze the insertion and deformation characteristics of acetabular components designed for dual-mobility systems based on component design, size, and reaming technique. Shell deformation was quantified in a validated worst-case scenario foam pinch model. Thin-walled, one-piece, and modular dual-mobility shells of varying size were implanted in under- and over-reamed cavities with insertion force measured and shell deformation assessed using digital image correlation. Increased shell size resulted in larger rim deformation in one-piece components, with a reduction in press-fit by 1 mm resulting in up to 48% reduction in insertion forces and between 23% and 51% reduction in shell deformation. Lower insertion forces and deformations were observed in modular components. Variability in acetabular reaming plays a significant role in the ease of implantation and component deformation in total hip arthroplasty. Modular components are less susceptible to deformation than thin-walled monoblock shells. Care should be taken to avoid excessive under-reaming, particularly in the scenario of large shell size and high-density patient bone stock.
Technology and application of the LTCC-based microfluidic module for urea determination (2015)

Purpose – The purpose of this paper is to focus on the technology and performance of the miniature microfluidic module for urea determination. The presented module was made using low-temperature co-fired ceramics (LTCC). It shows the possibility for the integration of the bioreceptor layers with structures that have been fabricated using modern microelectronic technology. Design/methodology/approach – The presented microfluidic module was fabricated using LTCC technology. The possibility for the fabrication of an enzymatic microreactor in a multilayer ceramic substrate, made of CeramTec glass ceramic (GC) material systems with an integrated thick-film heater, is studied. Different configurations of the LTCC/heater materials (gold, silvers and palladium-silver) are taken into account. The performance of the LTCC-based microfluidic module with the integrated heater and immobilized enzyme was examined experimentally. Findings – A compatible material for the heater embedded in the CeramTec GC-based structures was found. The preliminary measurements made for the test solution containing various concentrations of urea have shown stability (for seven days of operation) and a relatively high signal-to-noise ratio (above 3 pH units) for the microreactor’s output signal. Research limitations/implications – The presented research is a preliminary work which is focused on the fabrication of the LTCC-based microfluidic module, with an integrated heater and immobilized enzyme for urea determination. The device was positively tested using a model reaction of the hydrolysis of urea. However, urea concentration in real (biological) fluid should also be measured. Practical implications – The development of the LTCC-based microfluidic module for urea determination provides opportunity for the construction of a lab-on-chip, or μTAS-type system, for fast medical diagnoses and the continuous monitoring of various biochemical parameters, e.g. for estimating the effectiveness of hemodialysis. Originality/value – This paper shows the design, fabrication and performance of the novel microfluidic module for urea determination, made with LTCC technology.
Efficacy of an imidacloprid/flumethrin collar against fleas, ticks, mites and lice on dogs (2012)

The rapid insecticidal and acaricidal properties of the medicated collars against newly-acquired infestations of fleas and ticks and their sustained high levels of preventive efficacy have been clearly shown. Consequently they have the potential to prevent the transmission of vector-borne diseases and other conditions directly associated with infestation throughout an entire season of parasite abundance.
Role of cysteine amino acid residues on the RNA binding activity of human thymidylate synthase (2003)

The role of cysteine sulfhydryl residues on the RNA binding activity of human thymidylate synthase (TS) was investigated by mutating each cysteine residue on human TS to a corresponding alanine residue. Enzymatic activities of TS:C43A and TS:C210A mutant proteins were nearly identical to wild-type TS, while TS:C180A and TS:C199A mutants expressed >80% of wild-type enzyme activity. In contrast, TS:C195A was completely inactive. Mutant proteins, TS:C195A, TS:C199A and TS:C210A, retained RNA binding activity to nearly the same degree as wild-type human TS. RNA binding activity of TS:C43A was reduced by 30% when compared to wild-type TS, while TS:C180A was completely devoid of RNA binding activity. In vitro translation studies confirmed that mutant proteins TS:C43A, TS:C195A, TS:C199A and TS:C210A, significantly repressed human TS mRNA translation, while TS:C180A was unable to do so. To confirm the in vivo significance of the cysteine sulfhydryl residue, mutant proteins TS:C180A and TS:C195A were each expressed in human colon cancer HCT-C18:TS(-) cells that expressed a functionally inactive TS. A recombinant luciferase reporter gene under the control of a TS-response element was co-transfected into these same cells, and luciferase activity increased in the presence of the TS:C195A mutant TS protein to a level similar to that observed upon expression of wild-type TS protein. In contrast, luciferase activity remained unchanged in cells expressing the TS:C180A mutant protein. Taken together, these findings identify Cys-180 as a critical residue for the in vitro and in vivo translational regulatory effects of human TS.
Scattering of Waves by Steel Reinforcement in Concrete (1992)

The application of wave-sensing methods to the non-destructive evaluation of concrete structures requires often the use of simple (or at least tractable) models for the solution of the physical problem under consideration. For example, a concrete deck would ideally be represented as a laminated plate. However, steel reinforcement bars embedded in concrete constitute strong scatterers of elastic and acoustic waves of short wavelength. From a rigorous standpoint, this implies that the steel mesh cannot be represented simply as a homogenous layer of material with appropriate physical properties. However, if the wavelengths are not too short and the spacing between rebars not too great, such a strategy is indeed possible. This paper is concerned with the problem of elastic wave scattering by steel reinforcement and examines reflection/transmission patterns of plane waves in a homogeneous mass of concrete reinforced by equidistant steel bars. For this purpose three solutions are used, namely a first order scattering solution, an exact solution, and a solution based on a layered medium with equivalent material properties. It is found that for reasonably long wavelengths, the latter model provides acceptable results.
Surface micromachined magnetic actuators (1994)

A surface micromachined micromagnetic actuator (also called a magnetic flap) as an integrated part of an active micro electromechanical fluid control system is described. The flaps are fabricated by surface micromachining technology and are capable of achieving large deflections (above 100 /spl mu/m) with magnetic forces in stationary air. Special microfabrication issues involved in fabricating magnetic flaps with large areas are discussed. Mechanical characterizations of the flaps, including the intrinsic stresses of thin film materials and frequency response, are presented. Thermal actuation is capable of producing large flap displacements and has been theoretically and experimentally studied.
Optimisation of the Recovery Section of a Polyolefin Catalyst Manufacturing Process (2010)

In this article, we introduce a preliminary, neurobiologically informed model of group therapy that links the timing and nature of specific group interventions with hypothesized changing neurobiological needs of the group. We suggest that the observed phases of group development reflect an underlying reorganization of neuronal circuitry that occurs as members progress through a hierarchically organized treatment, and that this reorganization involves the integration and homeostatic rebalancing of subcortical and neural networks. Our preliminary Dynamic Relational Model suggests that an understanding of the neurobiological processes involved in group development may help inform and direct effective group-based psychotherapy interventions.
High Power Sugar Fuel Cells Using PEDOT*PSS, CNT and PtRu Composite Anode (2022)

Abstract Output characteristics of sugars/KOH fuel cells using PEDOT*PSS, CNT, and PtRu composite (anode)/cellophane/Pt (cathode)/air have been studied. The maximum power density of glucose demonstrated 60 mWcm−2, being the best in the world. The relative outputs were 1, 0.37, 0.51, 0.42, and 0.006 for glucose, fructose, lactose, maltose, and sucrose, respectively, depending on the reducibility of sugars. The hydrolysis of sucrose with acids resulted in the enhancement of output. The coulombic and energetic conversion efficiencies are discussed comparing experimental and theoretical estimations.
Design of Double Emulsions by Osmotic Pressure Tailoring (2004)

A method was developed allowing in situ adjustment of water-in-oil-in-water double emulsion (W/O/W) morphologies by tailoring the osmotic pressure of the water phases. The control of internal droplet size is achieved by altering the chemical potential of the external and internal water phases by dissolving neutral linear polysaccharides of suitable molecular weights. As a consequence of the different chemical potentials in the two aqueous phases, transport of water takes place modifying the initial morphology of the double emulsion. Self-diffusion 1H nuclear magnetic resonance (1H NMR) was used to assess transport mechanisms of water in oil, while a numerical model was developed to predict the swelling/shrinking behavior of W/O/W double emulsions. The model was based on a two-step procedure in which the equilibrium size of a single internal water droplet was first predicted and then the results of the single droplet were extended to the entire double emulsion. The prediction of the equilibrium size of an internal droplet was derived by the equalization of the Laplace pressure with the osmotic pressure difference of the two aqueous phases, as modeled by mean-field theory. The double emulsion equilibrium morphologies were then predicted by upscaling the results of a single drop to the droplet size distribution of the internal W/O emulsion. Good agreement was found between the theoretical predictions and the measurement of double emulsion droplet size distribution. Therefore, the present model constitutes a valuable tool for in situ control of double emulsion morphology and enables new possible applications of these colloidal systems.
Biomimetic Approaches to “Transparent” Photovoltaics: Current and Future Applications (2022)

There has been a surge in the interest for (semi)transparent photovoltaics (sTPVs) in recent years, since the more traditional, opaque, devices are not ideally suited for a variety of innovative applications spanning from smart and self-powered windows for buildings to those for vehicle integration. Additional requirements for these photovoltaic applications are a high conversion efficiency (despite the necessary compromise to achieve a degree of transparency) and an aesthetically pleasing design. One potential realm to explore in the attempt to meet such challenges is the biological world, where evolution has led to highly efficient and fascinating light-management structures. In this mini-review, we explore some of the biomimetic approaches that can be used to improve both transparent and semi-transparent photovoltaic cells, such as moth-eye inspired structures for improved performance and stability or tunable, coloured, and semi-transparent devices inspired by beetles' cuticles. Lastly, we briefly discuss possible future developments for bio-inspired and potentially bio-compatible sTPVs.
Building an Optimizing Compiler (1998)

Compiler structure graphs flow graph local optimization alias analysis static single assignment dominator-based optimization advanced techniques global optimization limiting resources scheduling and rescheduling register allocation object module.
Symmetric oxalates as active esterification reagent for activated ester - N,N'-disuccinimidyl oxalate (DSO) (1986)

Symmetric oxalates containing N-hydroxyimide or N-hydroxybenzotriazole group easily prepared from oxalyl chloride and N-hydroxyimide or N-hydroxybenzotriazole, are employed for the synthesizing of activated ester from corresponding N-protected amino acid. The active esters containing N-hydroxyimide or N-hydroxybenzotriazole derivatives react smoothly with nucleophiles such as amino acid to afford the corresponding dipeptides in high yields. In particular, N, N'-disuccinimidyl oxalate (DSO) is the most useful and easily handle reagent even in the synthesis of dipeptide of free carboxylic acid. In order to evaluate the local irritability of DSO, the eye and skin irritation tests were investigated with rabbit using DCC as a control substance. As shown in Table 1, 2 and Fig. 1 the local irritability of DSO was clearly weaker than that of DCC.
A 390 dpi live fingerprint imager based on feedback capacitive sensing scheme (2002)

A single-chip, 200/spl times/200 element sensor array grabs a fingerprint pattern without any optical or mechanical adaptors. Using this integrated sensor the fingerprint is captured at a rate ofl0/Frame/s by pressing the finger skin onto the chip surface. The fingerprint pattern is sampled by capacitive sensors that detect the electric field variation induced by the skin surface. The architecture is integrated in standard 2-metal 0.7 /spl mu/m digital CMOS technology. The idea of using a capacitive sensor array for detecting fingerprints has been suggested, but not implemented. The sensor described here uses a scheme, substantially different from previous approaches, based on feedback capacitance sensing.
A laser-cooled Atomic Clock in Space (2000)

This paper describes work aimed at producing a “Primary Atomic Reference Clock in Space (PARCS),” scheduled for flight on the International Space Station in 2004. The microgravity environment of space will allow this clock to achieve an uncertainty ten times lower than can be achieved on earth. The experimental objectives are to measure several relativistic effects on clocks and to provide both time and frequency references available as an international standards accessible to anyone on earth.
Design and performance of the Georgia Tech Aquatic Center photovoltaic system. Final report (1996)

A building-integrated DC PV array has been constructed on the Georgia Tech campus. The array is mounted on the roof of the Georgia Tech Aquatic Center (GTAC), site of the aquatic events during the 1996 Paralympic and Olympic Games in Atlanta. At the time of its construction, it was the world`s largest roof-mounted photovoltaic array, comprised of 2,856 modules and rates at 342 kW. This section describes the electrical and physical layout of the PV system, and the associated data acquisition system (DAS) which monitors the performance of the system and collects measurements of several important meteorological parameters.
One-pot three-component catalytic asymmetric synthesis of homoallylboronates (2012)

1. A novel one-pot three-component catalytic enantioselective reaction between bis(pinacolato)diboron, enals and 2-(triphenylphosphoranylidene)acetate esters employing inexpensive bench stable Cu salts and simple chiral amine as co-catalysts is presented. The reaction proceeds via a tandem catalytic asymmetric conjugate borane addition/Wittig sequence where the b-boration step is 1,4-selective and gives the corresponding homoallylboronate products with high enantiomeric ratios (up to 97.5:2.5 er).2. The direct intermolecular regiospecific and highly enantioselective a-allylic alkylation of linear aldehydes by combination of achiral bench stable Pd(0) complexes and simple chiral amines as co-catalysts is disclosed. The co-catalytic asymmetric chemoselective and regiospecific a-allylic alkylation reaction is linked in tandem with in situ reduction to give the corresponding 2-alkyl alcohols with high enantiomeric ratios (up to 98:2 er). It is also an expeditious entry to valuable 2-alkyl substituted hemiacetals and 2-alkyl-butane-1,4-diols.
Drive current enhancement in high-K/metal gate germanium-carbide pMOSFETs fabricated directly on Si substrates (2006)

High-k/metal gate pMOSFETs were fabricated on high-quality Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> for the first time. Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> layers with very low RMS roughness of ~3Aring were grown directly on Si by ultra-high-vacuum chemical vapor deposition (UHVCVD), without the use of relaxed Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x </sub> virtual substrates. Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> buried-channel (BC) and surface-channel (SC) pMOSFETs with EOT = 1.9 nm and L = 10 mum exhibited high drive currents of 10.8 and 15.2 muA/mum, respectively, for V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GS</sub> -V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> = -1.0 V. Compared to Si control devices, the BC pMOSFETs showed 2times enhancement in I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Dsat</sub> and 1.6times enhancement in the transconductance (G <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> ). The corresponding enhancements for the SC devices were 3times and 2times, respectively. These results represented an effective hole mobility enhancement of ~1.5times for the BC devices and ~2.5times for the SC devices over the universal curve for Si
Cell Biology of Human Host Cell Entry byCampylobacter jejuni (2014)

This chapter presents an overview of the interaction of Campylobacter jejuni with intestinal host cells and focuses on bacterial adherence and invasion into the intestinal epithelium, transcytosis across the epithelial mucosa, and ensuing damage to host cells. Campylobacter invasion into the epithelial mucosa appears to be an essential process leading to colitis. Although many researchers would agree with this general summary of Campylobacter invasion events, there still remains considerable confusion regarding how Campylobacter enter and cross the intestinal mucosa. In fact, researchers concluded, after treating T-84 cells with EGTA, that CadF-dependent invasion of epithelial cells occurs preferentially at the basolateral surface, which normally interacts with fibronectin. In the above study, the number of internalized C. jejuni F38011 increased approximately threefold after EGTA treatment and was then reduced ~80% by treating with anti-fibronectin antibody. A common theme among pathogenic invasive microorganisms is their ability to usurp the eukaryotic cell signaling systems both to allow for invasion and to trigger disease pathogenesis. The current data on signal transduction events involved in C. jejuni invasion suggest that host cell "invasion receptors" reside in filipin III-sensitive membrane microdomains (i.e., lipid rafts). Clinical infections, experimental infections in humans and animals, and in vitro analyses in cultured human cells have now clearly demonstrated that cell adherence and invasiveness are necessary steps in Campylobacter-induced inflammatory diarrhea. Much progress has been made in the past 10 years in the understanding of the cell biology of these events.
Supplementary Figure 6 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase (2023)

&lt;p&gt;Geneset analysis of HER2BOW trajectory mapping&lt;/p&gt;
Complementation of the <i>S. pombe Δcoq4</i>, <i>Δcoq6</i> and <i>Δcoq3</i> strains by Hs<i>COQ3</i>, Hs<i>COQ4</i> and Hs<i>COQ6</i>. (2015)

&lt;p&gt;(A, B) HPLC analyses of lipid extracts from the KH4 (&lt;i&gt;Δcoq4&lt;/i&gt;) strain expressing &lt;i&gt;S. pombe coq4&lt;/i&gt; or Hs&lt;i&gt;COQ4&lt;/i&gt; and the KH6 (&lt;i&gt;Δcoq6&lt;/i&gt;) strain expressing &lt;i&gt;S. pombe coq6&lt;/i&gt; or Hs&lt;i&gt;COQ6&lt;/i&gt;. Growth on minimal media (EMM) plates is also shown. (C) HPLC analyses of lipid extracts from the KH3 (&lt;i&gt;Δcoq3&lt;/i&gt;) strain expressing &lt;i&gt;S. pombe coq3&lt;/i&gt;, Hs&lt;i&gt;COQ3&lt;/i&gt;, or Hs&lt;i&gt;COQ3&lt;/i&gt; fused with a mitochondrial targeting sequence (Mt-signal).&lt;/p&gt;
Colorectal Cancer associated with pediatric inflammatory bowel disease: a case series (2021)

Patients with pediatric-onset IBD exhibited a much shorter disease duration than that of adult-onset IBD at the time of diagnosis of CRC, suggesting that surveillance endoscopy for the detection of precancerous lesions and early-stage cancer should be initiated earlier in pediatric patients than in adult patients.
Polymerizable Supramolecular Approach to Highly Conductive PEDOT:PSS Patterns (2017)

Owing to its high conductivity, solution processability, mechanical flexibility, and transparency, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) has been extensively explored for use in functional devices including solar cells, sensors, light-emitting diodes, and supercapacitors. The ability to fabricate patterned PEDOT:PSS on a solid substrate is of significant importance to develop practical applications of this conducting polymer. Herein, we describe a new approach to obtain PEDOT:PSS patterns that are based on a polymerizable supramolecular concept. Specifically, we found that UV irradiation of a photopolymerizable diacetylene containing PEDOT:PSS film followed by development in deionized water and subsequent treatment with sulfuric acid (glass and silicon wafer) or formic acid (PET) produces micron-sized PEDOT:PSS patterns on solid substrates. The newly designed photolithographic method, which can be employed to generate highly conductive (>1000 S/cm) PEDOT:PSS patterns, has many advantages including the use of aqueous process conditions, a reduced number of process steps, and no requirement for plasma etching procedures.
Low-field magnetoresistive properties of polycrystalline and epitaxial perovskite manganite films (1997)

The low-field magnetoresistance (MR) properties of polycrystalline La0.67Sr0.33MnO3 and La0.67CaO33MnO3 thin films with different grain sizes have been investigated and compared with epitaxial films. MR as high as 15% has been observed in the polycrystalline films at a field of 1500 Oe at low temperatures, whereas the MR of the epitaxial films is less than 0.3% in the same field range. Based on the magnetization dependence of the MR, the current-voltage characteristics, and the temperature dependence of the resistivity, we attribute the low-field MR to spin-dependent scattering of polarized electrons at the grain boundaries which serve as pinning centers for the magnetic domain walls.