gebhart/patrepeval huggingface dataset:
Systemic inhibition of BMP1-3 decreases progression of CCl4-induced liver fibrosis in rats (2017)

Liver fibrosis is a progressive pathological process resulting in an accumulation of excess extracellular matrix proteins. We discovered that bone morphogenetic protein 1-3 (BMP1-3), an isoform of the metalloproteinase Bmp1 gene, circulates in the plasma of healthy volunteers and its neutralization decreases the progression of chronic kidney disease in 5/6 nephrectomized rats. Here, we investigated the potential role of BMP1-3 in a chronic liver disease. Rats with carbon tetrachloride (CCl<sub>4</sub>)-induced liver fibrosis were treated with monoclonal anti-BMP1-3 antibodies. Treatment with anti-BMP1-3 antibodies dose-dependently lowered the amount of collagen type I, downregulated the expression of Tgfb1, Itgb6, Col1a1, and Acta2 and upregulated the expression of Ctgf, Itgb1, and Dcn. Mehanistically, BMP1-3 inhibition decreased the plasma levels of transforming growth factor beta 1(TGFβ1) by prevention of its activation and lowered the prodecorin production further suppressing the TGFβ1 profibrotic effect. Our results suggest that BMP1-3 inhibitors have significant potential for decreasing the progression of fibrosis in liver cirrhosis.
Proceedings of the NSSDC Conference on Mass Storage Systems and Technologies for Space and Earth Science Applications (1991)

The proceedings of the National Space Science Data Center Conference on Mass Storage Systems and Technologies for Space and Earth Science Applications held July 23 through 25, 1991 at the NASA/Goddard Space Flight Center are presented. The program includes a keynote address, invited technical papers, and selected technical presentations to provide a broad forum for the discussion of a number of important issues in the field of mass storage systems. Topics include magnetic disk and tape technologies, optical disk and tape, software storage and file management systems, and experiences with the use of a large, distributed storage system. The technical presentations describe integrated mass storage systems that are expected to be available commercially. Also included is a series of presentations from Federal Government organizations and research institutions covering their mass storage requirements for the 1990's.
J-Aggregates of Cyanine Dye for NIR-II in Vivo Dynamic Vascular Imaging beyond 1500 nm (2019)

Light in the second near-infrared window, especially beyond 1500 nm, shows enhanced tissue transparency for high-resolution <i>in vivo</i> optical bioimaging due to decreased tissue scattering, absorption, and autofluorescence. Despite some inorganic luminescent nanoparticles have been developed to improve the bioimaging around 1500 nm, it is still a great challenge to synthesize organic molecules with the absorption and emission toward this region. Here, we present <i>J</i>-aggregates with 1360 nm absorption and 1370 nm emission formed by self-assembly of amphiphilic cyanine dye FD-1080 and 1,2-dimyristoyl-<i>sn</i>-glycero-3-phosphocholine. Molecular dynamics simulations were further employed to illustrate the self-assembly process. Superior spatial resolution and high signal-to-background ratio of <i>J</i>-aggregates were demonstrated for noninvasive brain and hindlimb vasculature bioimaging beyond 1500 nm. The efficacy evaluation of the clinically used hypotensor is successfully achieved by high-resolution <i>in vivo</i> dynamic vascular imaging with <i>J</i>-aggregates.
Compensation for channel dispersion by nonlinear optical phase conjugation (1979)

It is proposed that the process of nonlinear optical phase conjugation can be utilized to compensate for channel dispersion and hence to correct for temporal pulse broadening. Specifically, a four-wave nonlinear interaction is shown to achieve pulse renarrowing. Spectral bandwidth constraints of the input pulse are presented for typical phase-conjugate interaction parameters.
Association of tyrosine protein kinase activity with mitochondria in human fibroblasts (1986)

A tyrosine protein kinase activity has been detected in the mitochondrial fraction purified from human fibroblasts. By enzymatic and sedimentation analysis this activity appeared to be localized in the mitochondrial outer membrane. Mitochondrial tyrosine phosphorylation was strictly dependent on the presence of Mn2+ ions. An inverse relationship between cell proliferation and mitochondrial protein phosphorylation on tyrosine residues has been found: a marked increase in the mitochondrial tyrosine kinase activity occurred when a significant reduction in the growth rate followed serum step-down. In mitochondria purified from resting cells, a protein band with apparent molecular weight of 50 kd appeared to be phosphorylated on tyrosine.
Development of rapid and robust stability-indicating method for analysis of ziprasidone (hydrochloride and freebase) as drug substance and in medicines by UPLC. (2012)

Ultra Performance Liquid Chromatography (UPLC) was employed to develop a rapid and robust method for the analysis of ziprasidone, both as a drug substance and in the final dosage forms. The application of this method in stability analyses was verified. Tests were carried out according to ICH/FDA guidelines, European Pharmacopeia, and United States Pharmacopeia rules, which take into account factors such as specificity, linearity, accuracy, and precision. Separation was performed on an Acquity UPLC BEH phenyl 1.7-microm column with a simple mobile phase, consisting of acetonitrile and water adjusted to pH 2.0 with ortho-phosphoric acid. Using this mobile phase and gradient elution, the separation was completed within 5 min. This method is very sensitive, and allows performing simultaneous identification, assay, and determination of impurities and related substances in one injection.
Mapping Octahedral Tilts and Polarization Across a Domain Wall in BiFeO3 from Z-Contrast Scanning Transmission Electron Microscopy Image Atomic Column Shape Analysis (2010)

Oxygen octahedral tilts underpin the functionality of a large number of perovskite-based materials and heterostructures with competing order parameters. We show how a precise analysis of atomic column shapes in Z-contrast scanning transmission electron microscopy images can reveal polarization and octahedral tilt behavior across uncharged and charged domain walls in BiFeO(3). This method is capable of visualizing octahedral tilts to much higher thicknesses than phase contrast imaging. We find that the octahedral tilt transition across a charged domain wall is atomically abrupt, while the associated polarization profile is diffuse (1.5-2 nm). Ginzburg-Landau theory then allows the relative contributions of polarization and the structural order parameters to the wall energy to be determined.
Frankenrigs: building character rigs from multiple sources. (2010)

We present a new rigging and skinning method which uses a database of partial rigs extracted from a set of source characters. Given a target mesh and a set of joint locations, our system can automatically scan through the database to find the best-fitting body parts, tailor them to match the target mesh, and transfer their skinning information onto the new character. For the cases where our automatic procedure fails, we provide an intuitive set of tools to fix the problems. When used fully automatically, the system can generate results of much higher quality than a standard smooth bind, and with some user interaction, it can create rigs approaching the quality of artist-created manual rigs in a small fraction of the time.
Bright CsPbBr3 Perovskite Nanocrystals with Improved Stability by In-Situ Zn-Doping (2022)

In this study, facile synthesis, characterization, and stability tests of highly luminescent Zn-doped CsPbBr3 perovskite nanocrystals (NCs) were demonstrated. The doping procedure was performed via partial replacement of PbBr2 with ZnBr2 in the precursor solution. Via Zn-doping, the photoluminescence quantum yield (PLQY) of the NCs was increased from 41.3% to 82.9%, with a blue-shifted peak at 503.7 nm and narrower spectral width of 18.7 nm which was consistent with the highly uniform size distribution of NCs observed from the TEM image. In the water-resistance stability test, the doped NCs exhibited an extended period-over four days until complete decomposition, under the harsh circumstances of hexane-ethanol-water mixing solution. The Zn-doped NC film maintained its 94% photoluminescence (PL) intensity after undergoing a heating/cooling cycle, surpassing the un-doped NC film with only 67% PL remaining. Based on our demonstrations, the in-situ Zn-doping procedure for the synthesis of CsPbBr3 NCs could be a promising strategy toward robust and PL-efficient nanomaterial to pave the way for realizing practical optoelectronic devices.
Security trends and advances in manufacturing systems in the era of industry 4.0 (2017)

The next industrial revolution will incorporate various enabling technologies. These technologies will make the product lifecycle of the manufacturing system efficient, decentralized, and well-connected. However, these technologies have various security issues, and when integrated in the product lifecycle of manufacturing systems can pose various challenges for maintaining the security requirements such as confidentiality, integrity, and availability. In this paper, we will present the various trends and advances in the security of the product lifecycle of the manufacturing system while highlighting the roles played by the major enabling components of Industry 4.0.
ChemInform Abstract: EIN MAKROISOPOLYANION DES MOLYBDAEN, MO36O(8‐)112 (1973)

Abstract Das beim Ansäuern von Molybdatlösungen nach Reaktion A entstehende Makroisopolyanion Mo 36 O 112 8‐ ist wahrscheinlich das größte einheitliche diskrete Anion, das bisher in Lösung nachgewiesen oder in Form eines Salzes isoliert wurde.
Digital mammography '96 : proceedings of the 3rd International Workshop on Digital Mammography, Chicago, U.S.A., 9-12 June 1996 (1996)

The Third Workshop on Digital Mammography included computer-aided diagnosis, image processing, detector and system design, image display, observer performance, transmission and archiving and clinical evaluation. Papers address topics such as: the effect of prompting on human observers; clinical experiences with computer-aided diagnosis and direct-digital mammograms; advances in digital mammograph lesions; and the quantitative analysis of mammographic lesions.
Mechanical Characteristics of Ankle Foot Orthosis and its Effect on Human Gait. (1997)

Ankle foot orthosis (AFO) assists the gait motion of persons with disability such as of hemiplegia, and the biomechanical function is the primary concern of AFO. In conventional prescription of AFO, the attention has been mainly focused on the ankle joint support at a secure position against the stumbling due to toe contact with floor during the swing phase of gait cycle, but little attention has been paid for its function during the stance phase. In this study, the mechanical characteristics of shoehorn-type AFO is examined in the context of the gait motion analysis during the stance phase of normal subjects, and by experimental analysis of the ankle joint stiffness in sagittal plane on a universal testing machine. Deformation of AFO is characterized by the relative angle between the shank and foot planes, and it is found that the stiffness of AFO depends strongly on the foot angle. The joint moment during the stance phase is evaluated for slow-speed gait with and without AFO. It is found that the knee extension moment of the gait with AFO is significantly larger than that without AFO. It is expected that the ankle joint constraint imposed by AFO results in a gait pattern different from the normal, although the resisting moment of AFO is not so significant in the joint moment.
Magnetic surveying using horizontal gradient vectors (1977)

Measurement of magnetic gradients by a method applicable on land, on the ocean, and in the air is discussed. Problems due to shallow anomalies are considered. 1 figure. (RWR)
Carbon microstructures for electrochemical studies (2001)

CARBON MICROSTRUCTURES FOR ELECTROCHEMICAL STUDIES Robert Kostecki, Xiang Yun Song and Kim Kinoshita Environmental Energy Technologies Division, and Lawrence Berkeley National Laboratory Berkeley, California 94720 Thin layers of photoresist were spin coated onto silicon wafers, and then carbonized to form smooth carbon films by heating in nitrogen for 1 hour at temperatures between 600 to 1100 o C. Well-defined carbon microstructures on Si wafers that are being considered for electrodes in a microbattery concept were obtained by additional processing steps involving patterning and lithography of the photoresist prior to carbonization. The status of the fabrication of carbon microelectrodes obtained by pyrolysis of photoresist, characterization of the carbons by surface-sensitive techniques and electrochemical analysis by cyclic voltammetry of the I - /I 3 - redox reaction is described. Key words: carbon microelectrode, Raman spectroscopy, I /I 3 redox reaction, photoresist INTRODUCTION Carbon-based materials are available in a variety of physical structures-large solid blocks, highly porous solid particles, fibers, small particles, etc. To produce these carbon structures requires different precursors and manufacturing processes. The precursor may be a gas, liquid, or solid which is heated at temperatures ranging from about 500 o C to near 3000 o C. The fact that a large number of carbons are available poses a problem for selecting the most appropriate one for use in electrochemical systems. It is through an understanding of the physicochemical properties and electrochemical behavior of carbon that a rational selection is possible. It is apparent from this discussion that a wide range of carbon materials, with vastly different physicochemical properties are available. Because many carbons are available, a thorough knowledge of their physicochemical and electrochemical properties is necessary to select the most suitable material for use in electrochemical technologies. The traditional electrochemical applications for carbon in solid electrode structures for the chlor-alkali industry (as well as in aluminum refining) are giving way to more diverse applications requiring high-surface-area carbon (i.e., capacitors, fuel cells, metal/air batteries, and high-energy lithium batteries). In each of these applications carbon has the desirable combination of acceptable electrical conductivity, chemical/electrochemical compatibility to the surrounding environment, and availability in the appropriate structure for fabrication into electrodes. In addition, the low cost of carbon relative to other electronic conductors is an important advantage for its widespread use in electrodes, particularly in electrochemical systems that must compete with existing technologies. Carbon is an integral part of many battery electrodes. In some electrodes, it plays a passive role as a conductive matrix (e.g., positive electrode containing metal oxides), and in others it is an active component as an electrocatalyst (e.g., positive electrode in
A Possible Solution to the Paradox of the “Lupus Anticoagulant”: Antiphospholipid Antibodies Accelerate Thrombin Generation by Inhibiting Annexin-V (1999)

A Possible Solution to the Paradox of the “Lupus Anticoagulant”: Antiphospholipid Antibodies Accelerate Thrombin Generation by Inhibiting Annexin-V -
On the use of dislocations to model interseismic strain and stress build-up at intracontinental thrust faults (2001)

Creeping dislocations in an elastic half-space are commonly used to model interseismic deformation at subduction zones, and might also apply to major intracontinental thrust faults such as the Main Himalayan Thrust. Here, we compare such models with a more realistic 2-D finite element model that accounts for the mechanical layering of the continental lithosphere and surface processes, and that was found to fit all available constraints on interseismic and long-term surface displacements. These can also be fitted satisfactorily from dislocation models. The conventional back-slip model, commonly used for subduction zones, may, however, lead to a biased inference about the geometry of the locked portion of the thrust fault. We therefore favour the use of a creeping buried dislocation that simulates the ductile shear zone in the lower crust. A limitation of dislocation models is that the mechanical response of the lithosphere to the growth of the topography by bending of the elastic cores and ductile flow in the lower crust cannot be easily introduced. Fortunately these effects can be neglected because we may assume, to first order, a stationary topography. Moreover, we show that not only can dislocation models be used to adjust surface displacements but, with some caution, they can also provide a physically sound rationale to interpret interseismic microseismicity in terms of stress variations.
Combining anaerobic digestion with enclosed tunnel composting. (2004)

As illustrated by the Ieper, Belgium waste treatment facility, the combination exports surplus energy as green electricity while returning nutrient-rich organic matter back to the soil.
Endo-beta-1,4-glucanase gene of Bacillus subtilis DLG (1987)

The DNA sequence of the Bacillus subtilis DLG endo-beta-1,4-glucanase gene was determined, and the in vivo site of transcription initiation was located. Immediately upstream from the transcription start site were sequences closely resembling those recognized by B. subtilis sigma 43-RNA polymerase. Two possible ribosome-binding sites were observed downstream from the transcription start site. These were followed by a long open reading frame capable of encoding a protein of ca. 55,000 daltons. A signal sequence, typical of those present in gram-positive organisms, was observed at the amino terminus of the open reading frame. Purification of the mature exocellular beta-1,4-glucanase and subsequent amino-terminal protein sequencing defined the site of signal sequence processing to be between two alanine residues following the hydrophobic portion of the signal sequence. The probability of additional carboxy-terminal processing of the beta-1,4-glucanase precursor is discussed. S1 nuclease protection studies showed that the amount of beta-1,4-glucanase mRNA in cells increased significantly as the culture entered the stationary phase. In addition, glucose was found to dramatically stimulate the amount of beta-1,4-glucanase mRNA in vivo. Finally, the specific activities of purified B. subtilis DLG endo-beta-1,4-glucanase and Trichoderma reesei QM9414 endo-beta-1,4-glucanase (EC 3.2.1.4) were compared by using the noncrystalline cellulosic substrate trinitrophenyl-carboxymethyl cellulose.
Resilient modulus of stabilized subgrade for flexible pavement design (2019)

This paper reports the resilient modulus of stabilized subgrade soil for flexible pavement design using chemical stabilizer; Sodium Silicate (SiO2). SiO2is a water based soil stabilizer which is currently being patented on application by Probase Manufacturing Sdn.Bhd. in stabilizing subgrade soil for low volume road construction. The resilient modulus of the stabilized subgrade soil; with particular variations values of additive content, dry density, moisture content and curing time were investigated. Repeated Triaxial load test was conducted on the stabilized subgrade soil, and the specimens were prepared with 100%, 95% and 90% of dry density, at optimum moisture content (WOpt), 3% dry of optimum (WOpt-3) and 3% wet of optimum (WOpt+3), and the amount of stabilizer used were 4%, 8% and 12% from dry density of the soil. It had been found that the density affects the resilient modulusof fine grained soil materials; however the magnitude of this effect is smaller compared to the effect of water (moisture). The addition of liquid SiO2stabilizer improves the stiffness (resilient modulus) of the soil and consequently, the optimum concentration of the stabilizer is found to be 4% at 95% density with WOpt-3 for subgrade soil stabilization from KENLAYER program. The analysis was supported by Asphalt Institute (AI) Models which was used to predict the number of load cycle thatlead to failure
Nesprins: from the nuclear envelope and beyond (2013)

Nuclear envelope spectrin-repeat proteins (Nesprins), are a novel family of nuclear and cytoskeletal proteins with rapidly expanding roles as intracellular scaffolds and linkers. Originally described as proteins that localise to the nuclear envelope (NE) and establish nuclear-cytoskeletal connections, nesprins have now been found to comprise a diverse spectrum of tissue specific isoforms that localise to multiple sub-cellular compartments. Here, we describe how nesprins are necessary in maintaining cellular architecture by acting as essential scaffolds and linkers at both the NE and other sub-cellular domains. More importantly, we speculate how nesprin mutations may disrupt tissue specific nesprin scaffolds and explain the tissue specific nature of many nesprin-associated diseases, including laminopathies.
Understanding Pedestrian-Vehicle Interactions with Vehicle Mounted Vision: An LSTM Model and Empirical Analysis (2019)

Pedestrians and vehicles often share the road in complex inner city traffic. This leads to interactions between the vehicle and pedestrians, with each affecting the other's motion. In order to create robust methods to reason about pedestrian behavior and to design interfaces of communication between self-driving cars and pedestrians we need to better understand such interactions. In this paper, we present a data-driven approach to implicitly model pedestrians' interactions with vehicles, to better predict pedestrian behavior. We propose a Long Short-Term Memory (LSTM) model that takes as input the past trajectories of the pedestrian and ego-vehicle, and pedestrian head orientation, and predicts the future positions of the pedestrian. Our experiments based on a real-world, inner city dataset captured with vehicle mounted cameras, show that the usage of such cues improve pedestrian prediction when compared to a baseline that purely uses the past trajectory of the pedestrian.
Changes in the Composition of Canine Respiratory Cells Obtained by Bronchial Lavage following Irradiation or Drug Immunosuppression (1976)

Canine respiratory cells, obtained by bronchial lavage, and blood leukocytes were monitored to observe cellular changes following acute and chronic immunosuppression. Irradiation (350 R) produced bone marrow suppression and prompt peripheral blood leukopenia, but did not affect recovery of pulmonary alveolar macrophages or lymphocytes for 12 days after. Treatment for 6 weeks with daily methylprednisolone (1 mg/kg) caused a progressive decrease in the number of recoverable respiratory lymphocytes, whereas alternate day methylprednisolone (2 mg/kg) had less effect. Cyclophosphamide in combination with steroids generally augmented the progressive loss of blood and respiratiory lymphocytes. Recovery of alveolar macrophages was not changed appreciably. Thus, the population of lung macrophages, sampled by pulmonary lavage, withstood acute and chronic forms of immunosuppression very well. In contrast, canine lymphocytes seem more susceptible to injury, especially to drug regimens containing steroids.