gebhart/patrepeval huggingface dataset:
Estrogen receptor α activation aggravates imiquimod‐induced psoriasis‐like dermatitis in mice by enhancing dendritic cell interleukin‐23 secretion (2020)

Abstract Our recent study has reported that estrogen receptors (ERs) are involved in several types of allergy development. This study aims to investigate the possible relationship between ER activation and development of imiquimod‐induced psoriasis‐like dermatitis. A mouse model of imiquimod‐induced psoriasis‐like dermatitis was generated by 5 days of topical application of 5% of imiquimod cream on the back of the ear and the shaved back skin of male BALB/c mice. From the second day of applying 5% imiquimod cream, either ERα selective agonist (propylpyrazoletriol [PPT] 2.5 mg/kg) or ERβ selective agonist (diarylpropionitrile, DPN; 2.5 mg/kg) was administered orally for four consecutive days. Immediately after the final imiquimod cream application, scratching behavior was video monitored for 2 hours. The ear‐swelling response was determined by comparing ear thickness before and after the final application of imiquimod cream. Twenty‐four hours after the final imiquimod application, back skin tissue and auricular lymph nodes were isolated under isoflurane anesthesia. Oral administration of PPT significantly induced itch behavior and proinflammatory responses, including the levels of interleukin (IL)‐17 and IL‐22, whereas DPN treatment did not influence either pruritic or proinflammatory responses. In addition, IL‐23 contribution by dendritic cells was identified using ER agonists on pretreated lipopolysaccharide (LPS)‐stimulated murine bone marrow derived dendritic cells (BMDCs). PPT also significantly enhanced IL‐23 secretion by LPS‐stimulated BMDCs. Our findings indicate that the activation of ERα, but not ERβ, is directly associated with inflammatory and pruritic responses in a mouse model of the imiquimod‐induced psoriasis by enhancing the secretion of IL‐23 by dendritic cells.
Introduction: Mapping and control of complex cardiac arrhythmias (2002)

This paper serves as an introduction to the Focus Issue on mapping and control of complex cardiac arrhythmias. We first introduce basic concepts of cardiac electrophysiology and describe the main clinical methods being used to treat arrhythmia. We then provide a brief summary of the main themes contained in the articles in this Focus Issue. In recent years there have been important advances in the ability to map the spread of excitation in intact hearts and in laboratory settings. This work has been combined with simulations that use increasingly realistic geometry and physiology. Waves of excitation and contraction in the heart do not always propagate with constant velocity but are often subject to instabilities that may lead to fluctuations in velocity and cycle time. Such instabilities are often treated best in the context of simple one- or two-dimensional geometries. An understanding of the mechanisms of propagation and wave stability is leading to the implementation of different stimulation protocols in an effort to modify or eliminate abnormal rhythms. (c) 2002 American Institute of Physics.
The configuration of glaucarubin (1965)

S. C. Nyburg, G. L. Walford and P. Yates, Chem. Commun. (London), 1965, 203 DOI: 10.1039/C19650000203
SPKI Requirements (1999)

The IETF Simple Public Key Infrastructure [SPKI] Working Group is tasked with producing a certificate structure and operating procedure to meet the needs of the Internet community for trust management in as easy, simple and extensible a way as possible.
The MIT-Green Bank (MG) 5 GHz survey (1986)

view Abstract Citations (138) References (25) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS The MIT--Green Bank (MG) 5 GHz Survey Bennett, C. L. ; Lawrence, C. R. ; Burke, B. F. ; Hewitt, J. N. ; Mahoney, J. Abstract The catalog yielded by the MIT-Green Bank 5-GHz survey contains 5974 sources with S/N ratio greater than 5; a supplemental catalog contains 3836 possible detections with S/N of less than 5. The reliability of the main list is measured to be about 96 percent, with a completeness of about 95 percent. Flux density errors are a function of flux density. A comparison is presently made of survey sources from the Douglas et al. (1980) 365-MHz Texas survey; spectral indices are computed for coincident sources, and the distribution of spectral indices is discussed. Publication: The Astrophysical Journal Supplement Series Pub Date: May 1986 DOI: 10.1086/191108 Bibcode: 1986ApJS...61....1B Keywords: Astronomical Catalogs; Radio Sources (Astronomy); Centimeter Waves; Radiant Flux Density; Radio Spectra; Radio Telescopes; Astrophysics; RADIO SOURCES: GENERAL; RADIO SOURCES: IDENTIFICATIONS full text sources ADS | data products NED (5979) SIMBAD (108) CDS (3) Related Materials (2) Catalog: 1999yCat.8052....0B Catalog: 2003yCat.8052....0B
Constructive Methods for Scheduling Uniform Loop Nests (1994)

This paper surveys scheduling techniques for loop nests with uniform dependences. First we introduce the hyperplane method and related variants. Then we extend it by using a different affine scheduling for each statement within the nest. In both cases we present a new, constructive and efficient method to determine optimal solutions, i.e. schedules whose total execution time is minimum. 1 Introduction Loop nests lie in the heart of supercompilers-parallelizers for supercomputers. On one hand their importance in terms of applications is evident: in many scientific programs, the time spent in the execution of a small number of loops represents a large fraction of the total execution time, while the potential parallelism of these loops is very important. On the other hand, the regular and repetitive structure of loop nests greatly facilitates the use of dependence analysis techniques and of scheduling and allocation strategies. The general problem of finding the optimal scheduling for a ...
Anthropogenic CO 2 emissions in Africa (2008)

Abstract. An understanding of the regional contributions and trends of anthropogenic carbon dioxide (CO2) emissions is critical to design mitigation strategies aimed at stabilizing atmospheric greenhouse gases. Here we report CO2 emissions from the combustion of fossil fuels and land use change in Africa for various time periods. Africa was responsible for an average of 500 TgC y−1 for the period 2000–2005. These emissions resulted from the combustion of fossil fuels (260 TgC y−1) and land use change (240 TgC y−1). Over this period, the African share of global emissions from land use change was 17%. For 2005, the last year reported in this study, African fossil fuel emissions were 285 TgC accounting for 3.7% of the global emissions. The 2000–2005 growth rate in African fossil fuel emissions was 3.2% y−1, very close to the global average. Fossil fuel emissions per capita in Africa are among the lowest in the world, at 0.32 tC y−1 compared to the global average of 1.2 tC y−1. The average amount of carbon (C) emitted as CO2 to produce 1 US $ of Gross Domestic Product (GDP) in Africa in 2005 was 187 gC/$, close to the world average of 199 gC/$. With the fastest population growth in the world and rising per capita GDP, Africa is likely to increase its share of global emissions over the coming decades although emissions from Africa will remain low compared to other continents.
Neurofilament Light Chain Related to Longitudinal Decline in Frontotemporal Lobar Degeneration (2020)

CSF NfL is associated with longitudinal clinical decline in relevant cognitive domains in patients with FTLD-TDP after controlling for demographic factors and core AD CSF analytes and may also be related to longitudinal decline in executive functioning in FTLD-tau.
Computational and Experimental Studies of Inhibitor Design for Aldolase A (2019)

Glycolytic enzyme fructose-bisphosphate aldolase A is an emerging therapeutic target in cancer. Recently, we have solved the crystal structure of murine aldolase in complex with naphthalene-2,6-diyl bisphosphate (ND1) that served as a template of the design of bisphosphate-based inhibitors. In this work, a series of ND1 analogues containing difluoromethylene (-CF<sub>2</sub>), methylene (-CH<sub>2</sub>), or aldehyde substitutions were designed. All designed compounds were studied using molecular dynamics (MD) simulations with the AMOEBA force field. Both energetics and structural analyses have been done to understand the calculated binding free energies. The average distances between ligand and protein atoms for ND1 were very similar to those for the ND1 crystal structure, which indicates that our MD simulation is sampling the correct conformation well. CF<sub>2</sub> insertion lowers the binding free energy by 10-15 kcal/mol, while CF<sub>2</sub> substitution slightly increases the binding free energy, which matches the experimental measurement. In addition, we found that NDB with two CF<sub>2</sub> insertions, the strongest binder, is entropically driven, while others including NDA with one CF<sub>2</sub> insertion are all enthalpically driven. This work provides insights into the mechanisms underlying protein-phosphate binding and enhances the capability of applying computational and theoretical frameworks to model, predict, and design diagnostic strategies targeting cancer.
Development of sensing systems printed with conductive ink on gear surfaces: manufacturing of meander line antenna by laser-sintered silver nano-particles (2017)

Health monitoring methods for machines have been the subject of considerable efforts to maintain it at an appropriate timing. Failures of rotating machine elements can cause severe accidents, thus, to detect such failures is an important issue. However, health monitoring of rotating machine elements, such as gears, is challenging because of rotation at high speed in gearboxes, geometric complexity, space limitation for measurements, or another operation conditions. The long-term objective of the present research is to develop smart sensor systems for detecting gear failure signs. As the very first step, this paper proposes a new method to manufacture electrical circuits, such as sensors or antennas, on gears. We print these circuits directly on the gear surface using a laser sintering technique of conductive ink. For this purpose, we have begun to develop a 4-axis laser printing system. This paper shows the laser sintering conditions of the conductive ink splayed on steel plates insulated by polyimide layers. The conductivity of the printed lines was evaluated through observation with a miniature scanning electron microscope. Finally, according to the obtained laser sintering conditions, a meander line antenna was printed as a part of smart sensor systems.
Decision-making by nematodes in complex microfluidic mazes (2011)

Nematodes are microscopic, soil-dwelling worms that navigate through soil particles in search of food or a suitable host. Most nematode species employ a myriad of physical and chemical cues that define their navigation strategies. Here, we demonstrate a microfluidic method to observe and characterize the physical aspects of nematode navigation at real-time. The microfluidic devices comprise a series of interconnected T-maze or cylindrical structures of varying geometry. At each physical intersection, nematodes are given the choice to migrate left or right. We found that this decision-making of nematodes is influenced by the angle of intersection of T-maze structures. We further showed that nematodes can be passively directed to move in a linear direction by carefully adjusting the position and spacing of cylindrical obstacles in its path. The experiments were conducted on two nematodes (non-parasitic C. elegans and pigparasitic Oesophagostomum dentatum) and in the absence of any chemical or electrical stimulants.
Discovery Potent of Thiazolidinedione Derivatives as Antioxidant, α-Amylase Inhibitor, and Antidiabetic Agent (2021)

This work aimed to synthesize safe antihyperglycemic derivatives bearing thiazolidinedione fragment based on spectral data. The DFT theory discussed the frontier molecular orbitals (FMOs), chemical reactivity of compounds, and molecular electrostatic potential (MEP) to explain interaction between thiazolidinediones and the biological receptor. α-amylase is known as the initiator-hydrolysis of the of polysaccharides; therefore, developing α-amylase inhibitors can open the way for a potential diabetes mellitus drug. The molecular docking simulation was performed into the active site of PPAR-γ and α-amylase. We evaluated in vitro α-amylase's potency and radical scavenging ability. The compound <b>6</b> has the highest potency against α-amylase and radical scavenging compared to the reference drug and other members. They have been applied against anti-diabetic and anti-hyperlipidemic activity (in vivo) based on an alloxan-induced diabetic rat model during a 30-day treatment protocol. The most potent anti hyperglycemic members are <b>6</b> and <b>11</b> with reduction percentage of blood glucose level by 69.55% and 66.95%, respectively; compared with the normal control. Other members exhibited moderate to low anti-diabetic potency. All compounds showed a normal value against the tested biochemical parameters (CH, LDL, and HDL). The ADMET profile showed good oral bioavailability without any observed carcinogenesis effect.
III- V/Si Tandem Cells Utilizing Interdigitated Back Contact Si Cells and Varying Terminal Configurations (2017)

Integrating wide-bandgap III-V with Si solar cells has been shown to yield higher efficiencies than Si alone: As also presented at this conference, four-terminal efficiencies exceeding 32% have been attained. In this contribution, independent and electrically connected operation of the subcells in such tandem cells is examined. The optics of the tandem cell change significantly if a conducting interconnect, rather than an insulating glass slide, is required between the subcells. These effects are studied and optically optimized structures for different types of tandem cell operation are presented. It is found that minimizing reflection at the conductive interface between the two cells while maintaining conductivity is the key challenge faced in such devices.
Integrated Automation of High-Throughput Screening and Reverse Phase Protein Array Sample Preparation (2014)

High-throughput screening of genome wide siRNA- or compound libraries is currently applied for drug target and drug discovery. Commonly, these approaches deal with sample numbers ranging from 100,000 to several millions. Efforts to decrease costs and to increase information gained include multiplexing readouts, but this has a natural limitation. High-content screening via image acquisition and analysis allows multiplexing of few parameters, but is connected to substantial time consumption and complex logistics. <br/>We report on integration of Reverse Phase Protein Arrays (RPPA)-based readouts into automated robotic high-throughput screens, which allows subsequent protein quantification. In this integrated solution, samples are directly forwarded to automated cell lysate preparation and preparation of dilution series, including reformatting to a protein spotter-compatible format after the high-throughput screening. Tracking of huge sample numbers and data analysis from a high-content screen to RPPAs is accomplished via MIRACLE, a custom made software suite developed by us. To this end, we demonstrate that the RPPAs generated in this manner deliver reliable protein readouts and that GAPDH and TFR levels can be used for normalization of protein amounts as they correlate highly with measured cell viability. Thus, this strategy offers ample options for multiplexed screen readouts via consecutive protein quantifications.
A preliminary health technology assessment of a guidance system for interventional radiology (2015)

Disruptive innovation in biomedical devices have to be carefully assessed in order to be included in the clinical practice, especially when these new systems interact with the human body. In this scenario the guidance devices for interventional radiology represent an area of great interest. In this paper a CT-navigation system, SIRIO, used for percutaneous interventions such as biopsy, thermal ablation, percutaneous interventional, is tested and assessed. The technical features of the system in terms of efficacy and safety and the comparison with the traditional CT-guided biopsy are analyzed. According to the clinical evidences, biopsies carried out with SIRIO show an important reduction of number of CT scans, procedure's time and radiation dose absorbed by the patients. The analysis of the technology costs, the social impact related to the benefits to clinicians and patients are also reported. Although SIRIO does not have an appropriate reimbursement procedure, short- and long-term benefits introduced by this device are discussed.
Optimization of the discharge cut-off voltage in LiFePO4 battery packs (2019)

Considering that the voltage and capacity/energy level of a single battery cell cannot meet the requirements of electric vehicles, hundreds of battery cells are usually connected in series/parallel. The discharge cut-off voltage of the battery cells is an important factor affecting the consistency of the terminal voltage and the capacity usage efficiency (i.e., the ratio of the discharged capacity to the nominal capacity) for a battery pack. This paper presents an optimization method for determining the LiFePO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> battery cell discharge cut-off voltage considering three factors: capacity usage efficiency, terminal voltage dispersion, and minimum terminal voltage. By applying this optimization method to different number of series-connected battery cells, the relationship between the optimized discharge cut-off voltage and the number of battery cells is deduced, and this relationship is instructive for the operation of the battery pack. Compared with the conventional method where the discharge cut-off voltage is 2 V, the terminal voltage dispersion is greatly reduced and the maximum rate of variation is 10.7%. At the same time, the minimum terminal voltage increases by about 1.5% and the capacity usage efficiency only declines by about 0.5%. Consequently, the battery cells will not be over-discharged because the minimum terminal voltage is larger than 2 V. The rate of decline of the capacity usage efficiency is small and it can be ignored. Moreover, the level of consistency among the terminal voltage of the battery cells is improved and lifetime of the battery pack will be extended.
Cross-Beam Electric-Discharge Convection Laser (1971)

An experimental investigation of a 60-cm-wide × 2.5-cm-high N2–CO2 cross-beam electric-discharge convection laser (EDCL) is described. Experiments relating to the achievement of uniform and stable discharges in the rectangular channel and measurements of laser optical properties are reviewed.
Synthesis of Symmetrical Triblock Copolymers of Styrene and N‐isopropylacrylamide Using Bifunctional Bis(trithiocarbonate)s as RAFT Agents (2009)

Abstract Six new bifunctional bis(trithiocarbonate)s were explored as RAFT agents for synthesizing amphiphilic triblock copolymers ABA and BAB, with hydrophilic “A” blocks made from N ‐isopropylacrylamide and hydrophobic “B” blocks made from styrene. Whereas the extension of poly( N ‐isopropylacrylamide) by styrene was not effective, polystyrene macroRAFT agents provided the block copolymers efficiently. End group analysis by 1 H NMR spectroscopy supported molar mass analysis and revealed an unexpected side reaction for certain bis(trithiocarbonate)s, namely a fragmentation to simple trithiocarbonates while extruding ethylenetrithiocarbonate. The amphiphilic block copolymers with short polystyrene blocks are directly soluble in water and self‐organize into thermoresponsive micellar aggregates. magnified image
Posterior cortical atrophy: Unique features (1998)

Abstract Posterior cortical atrophy (PCA) is a visual-cognitive syndrome caused by Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD), or subcortical gliosis. We report a case of posterior cortical atrophy unique in (1) comprehensive documentation of clinical, radiologic, electroencephalograph, metabolic and histopathologic findings, (2) repeated clinical and laboratory assessment, and (3) establishment of unique occipital subcortical gliosis in a patient with AD. Clinical manifestations of PCA caused by AD included visual agnosia, cortical blindness, optic apraxla, delusions, hallucinations, agitation, depression, amnestic deficit, Wernicke's aphasia, acalculia, and left/right disorientation. Posterior cortical atrophy produced by AD can be demonstrated on magnetic resonance imaging, positron emission tomography, and electroencephalography; determination of the etiology requires tissue examination. Autopsy-diagnosed cases in the literature document PCA due to CJD and AD with equal frequency.
Angioscopy-guided semiclosed technique for in situ bypass with a novel flushing valvulotome: early results. (1992)

To allow and facilitate endoluminal vein preparation under angioscopic guidance for in situ bypass grafting, a Mill's valvulotome was equipped with a flushing channel. The advantages of the novel valvulotome are obvious: it allows perfect angioscopic view within a saphenous vein that still contained blood by adjusting the jet of lactated Ringer's solution directly to the lens of the angioscope; it permits the use of very small angioscopes without integrated flushing channels, preventing endothelial damage. The described technique was tested in 27 peripheral reconstructions in 26 patients. The secondary cumulative patency rate within a follow-up time of 4 to 30 months (mean, 14 months) was 89%. The described technique substantially facilitates in situ bypass grafting and minimizes early and late complications and further improves surgical outcome.
Gamma irradiation on Alstroemeria aurea G. in vitro rhizomes: an approach to the appropriate dosage for breeding purposes (2012)

Gamma irradiation has been widely used as a breeding technique to obtain new cultivars in ornamental species such as Alstroemeria, where several cultivars have been obtained through rhizome radiation. The optimum dosage for an appropriate induction of mutation must be considered for breeding purposes and it depends mainly on plant susceptibility. Thus in this study in vitro cultured rhizomes of Alstroemeria aurea were irradiated with a gamma source using different dosages to evaluate the direct effect produced. Damage and number of rhizome sprouting were observed and recorded during 61 days after irradiation. At the end of this period, rhizomes were weighted and mortality was evaluated. Both mortality and weight increased depending on dosage. All irradiated rhizomes showed early sprouting in comparison with control (0 Gy) and no significant difference in final number of shoots after 61 days among irradiated treatments was observed. Bleaching and necrosis was observed in all irradiated rhizomes and was more evident at higher doses. LD50 was established at about 40 Gy and the optimum dosage to induce mutation was suggested between 2.5 and 5 Gy, when the growth was reduced in 50%, and probably this dosage could be used for breeding purposes.