gebhart/patrepeval huggingface dataset:
Four distannoxane derivatives containing the bidentate 2-amidoethyl ligand (2011)

Structures containing cyclic, oxygen bridged complexes of general form (RSnCl2OR‘)2, where R is the bidentate (2-amidoethyl-C,O) ligand, are described. In 1 and 2R‘ is H and Me, respectively, while 3 is the methanol solvate of 1 and 4 a 1 : 1 co-crystal of 1 and 1,2-bis(n-propylsulfinyl)ethane. In all of the structures tin is six-coordinate in an octahedral environment distorted by the bite angle of the bidentate ligand and, most markedly, by the intra-ring O—Sn—O angles involving the bridging oxygen atoms. The creation of three- and two-dimensional connectivity in the supramolecular structures is dominated by intermolecular hydrogen-bonds with the amide NH2 as the donor species.
A Study of Monoamine Metabolism in Human Epilepsy (1989)

Fourteen patients with intractable epilepsy underwent surgical resection of their epileptogenic focus. Hippocampal and temporal cortical samples were obtained, and subjected to high performance liquid chromatography with electrochemical detection. Levels of 5-hydroxyindoleacetic acid (5-HIAA) in actively spiking temporal cortex were 0.454 +/- 0.012 ng/mg (mean +/- SEM), contrasting with less actively spiking cortex values of 0.248 +/- 0.042 ng/mg and normal literature values, obtained from post-mortem material, of 0.140 +/- 0.050 ng/mg. Similarly, homovanillic acid (NVA) levels were significantly increased in epileptic tissue compared to normal literature values. Actively spiking cortex values were 0.172 +/- 0.001 pg/mg, less active cortex values were 0.058 +/- 0.012 pg/mg, and literature values were 0.011 +/- 0.002 pg/mg. Although a direct statistical comparison between the data reported here and literature values may not be valid, the findings show a continuum from normal through increasingly active electrode sites, likely reflecting a true biologic phenomena. Similarly, statistically significant increases in 5-HIAA and HVA levels were found in hippocampal tissue, which also showed significantly lower dihydroxyphenylacetic acid levels. We conclude that raised levels of serotonin and dopamine metabolites in actively spiking cortex likely reflect an increase in their turnover, and are an epileptic epiphenomenon. Exaggeration of turnover may represent the "metabolic noise" of epilepsy, rather than a concerted strategy of local or distal neurons to contain an epileptogenic focus.
Fabrication, Characterization and Application of Sugar Microneedles for Transdermal Drug Delivery (2017)

Maltose microneedles are a promising physical technique to increase skin delivery.
An Evaluation Study of Hybrid Energy Storage System for Plug-In Hybrid Electric Buses (2017)

This paper reviews different configurations of the hybrid-energy-storage-system (HESS), a combination of Li-ion Battery (LiB) pack, Li-ion capacitor (LiC) bank, and dc-dc converters, for Plug-in hybrid electric (PHE) buses. A new HESS configuration is proposed to improve the efficiency of power transfer from battery port and reduce the rating voltage of LiC bank associated the cell balancing problem. The simulation results with a standard SORT driving cycle will be used to optimize the sizing of LiB and LiC packs. The comparative analysis illustrates that the proposed configuration has several merits against the conventional hybrid topology based on high-energy batteries and electrical double-layer capacitors in term of weight and volume.
Skin microbiota analysis-inspired development of novel anti-infectives (2020)

Our study gives examples of how analysis of bacterial interactions in the human microbiota can be explored for the development of novel, effective anti-infective strategies. Video Abstract.
Multichannel Intraluminal Impedance in the Evaluation of Patients with Persistent Globus on Proton Pump Inhibitor Therapy (2006)

In adults on PPI therapy with refractory globus, acid reflux does not predict globus symptoms. Through detection of nonacid reflux, pH/MII increased the yield of standard pH testing in identifying positive symptom indices. Additionally, pH/MII provided important information regarding reflux-symptom correlation. Proximal reflux may be predictive of globus symptoms.
Acute, Chronic, and Prenatal Exposure to Cannabidiol (CBD) Differentially Affects Anxiety and Successful Birthrate in Mice (2022)

As the medicalization of marijuana occurs across the United States, the main non‐psychoactive component of the marijuana, cannabidiol (CBD), has gained recognition. Given that anxiety is the most common type of mental illness in the United States, our objective was to access the therapeutic potential of CBD administration. We hypothesized that CBD could mitigate anxiety for chronic but not acute treatments in mice and would not have long‐term behavioral consequences when administered perinatally. Our methods employed 3‐mo. Kv1.3‐/‐ (KO) anxiety prone mice, or wildtype (WT) mice that were treated either acutely (daily for 1 wk), chronically (18 doses over 1 mo.), or throughout gestation and lactation (daily). Mice in the acute and chronic treatment groups were randomly assigned to intraperitoneal injection of drug (CBD = 10 or 20 mg/kg) or vehicle solution. CBD administered to dams was provided orally via strawberry jam (100 mg/kg). The effect of perinatal exposure to CBD was assessed at 3 mo. of age. Mice were behaviorally assessed using five tasks: the elevated plus maze (EPM), the light‐dark box (LDB), the marble burying test, a 1‐ and 24‐hour memory test, and an object attention test for ADHD. Mice treated acutely with the drug exhibited decreased obsessive compulsive behavior (buried less marbles) in only male mice, and the required dose to produce this behavior was higher for KO mice. In the LDB test, CBD lessened anxiety for both sexes, yet WT females required a lower CBD dose than WT male mice; in KO mice, CBD was anxiogenic rather than anxiolytic for both sexes. When mice were challenged with the EPM, mice spent more time in the closed arms regardless of sex, genotype, or drug treatment. The only exception was CBD treated female KO mice exhibited anxiety in the EPM, spending more time in the closed arms following drug treatment. Although acute CBD decreased obsessive compulsive behavior, when administered chronically the drug had no effect in either WT or KO mice. Similar to acute CBD administration in WT mice, chronic drug administration lessened anxiety in the LDB (increased time in the light compartment). However, in KO mice, chronic administration of CBD was without effect in the LDB. For mice treated perinatally, there was no significant drug effect for litter size (p = 0.3619), time to birth (p = 0.4210), or maternal weight gain (p = 0.1588). CBD‐treated offspring had a lower survival rate in that 48.5% of CBD‐treated pups died before weaning age (23 days) whereas only 5.7% of jam treated pups died prior to weaning (p = 0.0355). In conclusion, our data suggest that CBD may act as an anxiolytic drug in WT mice with dose and sex dependency. CBD failed to alleviate anxiety in KO mice, suggesting that CBD may not be affective in subjects that already have trait anxiety rather than situation anxiety. CBD had no effect on object memory or ADHD‐like behaviors regardless of dose, duration, or genotype.
The Geometric and Electronic Structure of a One‐Electron‐Oxidized Nickel(II) Bis(salicylidene)diamine Complex (2007)

Class III delocalization? The isolation and analysis of the ligand-radical title complex has allowed description of the changes in bonding from the reduced form as well as the extent of delocalization. The intense low-energy absorption of the oxidized complex can be described as a ligand-radical transition of a highly delocalized class III mixed-valence compound. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701194_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Decision problems for propositional linear logic (2002)

It is shown that, unlike most other propositional (quantifier-free) logics, full propositional linear logic is undecidable. Further, it is provided that without the model storage operator, which indicates unboundedness of resources, the decision problem becomes PSPACE-complete. Also established are membership in NP for the multiplicative fragment, NP-completeness for the multiplicative fragment extended with unrestricted weakening, and undecidability for certain fragments of noncommutative propositional linear logic.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Analysis of Content Availability at Network Failure in Information-Centric Networking (2020)

In recent years, ICN (Information-Centric Networking) has been under the spotlight as a network that mainly focuses on transmitted and received data rather than on the hosts that transmit and receive data. Generally, the communication networks such as ICNs are required to be robust against network failures caused by attacks and disasters. One of the metrics for the robustness of conventional host-centric networks, e.g., TCP/IP network, is reachability between nodes in the network after network failures, whereas the key metric for the robustness of ICNs is content availability. In this paper, we focus on an arbitrary ICN network and derive the content availability for a given probability of node removal. Especially, we analytically obtain the average content availability over an entire network in the case where just a single path from a node to a repository, i.e., contents server, storing contents is available and where multiple paths to the repository are available, respectively. Furthermore, through several numerical evaluations, we investigate the effect of the structure of network topology as well as the pattern and scale of the network failures on the content availability in ICN. Our findings include that, regardless of patterns of network failures, the content availability is significantly improved by caching contents at routers and using multiple paths, and that the content availability is more degraded at cluster-based node removal compared with random node removal.
On the resiliency of wireless sensor networks with circulation graphs (2008)

One of the challenges in military wireless sensor networks is the determination of an information collection infrastructure that minimizes battery power consumption while being highly resilient against sensor and link failures. In our previous work we have proposed a heuristic for constructing an information flow graph in wireless sensor networks based on the mammalian circulatory system, with the goal of minimizing the energy consumption. In this paper we focus mainly on the resilience benefits that can be achieved when constructing such information flow graphs. We analyze the resilience of circulatory graphs constructed on top of regular as well as random topologies. We assume two modes of failure, random and targeted attacks, and we compare the resilience of the circulatory graphs against tree graphs.
A Safe Screening Rule for Sparse Logistic Regression (2013)

The l1-regularized logistic regression (or sparse logistic regression) is a widely used method for simultaneous classification and feature selection. Although many recent efforts have been devoted to its efficient implementation, its application to high dimensional data still poses significant challenges. In this paper, we present a fast and effective sparse logistic regression screening rule (Slores) to identify the 0 components in the solution vector, which may lead to a substantial reduction in the number of features to be entered to the optimization. An appealing feature of Slores is that the data set needs to be scanned only once to run the screening and its computational cost is negligible compared to that of solving the sparse logistic regression problem. Moreover, Slores is independent of solvers for sparse logistic regression, thus Slores can be integrated with any existing solver to improve the efficiency. We have evaluated Slores using high-dimensional data sets from different applications. Extensive experimental results demonstrate that Slores outperforms the existing state-of-the-art screening rules and the efficiency of solving sparse logistic regression is improved by one magnitude in general.
Symplectomorphic registration with phase space regularization by entropy spectrum pathways (2018)

The method has shown an excellent performance and the panel of deformations was instrumental to quantify its repeatability and reproducibility in comparison to several available alternative approaches.
Bisphosphonate therapy for bone loss in patients with osteoporosis and periodontal disease: clinical perspectives and review of the literature. (2006)

As the baby boomer generation in the United States ages, more patients are using bisphosphonates for systemic bone diseases like osteoporosis. Because of their ability to inhibit bone resorption and osteoclastic activity, bisphosphonates may also be beneficial in modulating host response for periodontal disease management. This literature review examines the mechanism of action for bisphosphonates and their uses in treating periodontal disease. The dental profession should continue to evaluate this class of drugs and to closely monitor patients who are on bisphosphonate therapy.
SAMPTA'09, International Conference on SAMPling Theory and Applications (2010)

ORGANIZING COMMITTEE: General chairs: • Laurent Fesquet (TIMA, Grenoble Institute of Technology) • Bruno Torrésani (LATP, Université de Provence, Marseille) Local committee • Sandrine Anthoine (I3S, CNRS, SophiaAntipolis) • Karim Kellay (LATP, Université de Provence, Marseille) • Matthieu Kowalski (LATP, Université de Provence, Marseille) • Clothilde Melot (LATP, Université de Provence, Marseille) • El Hassan Youssfi (LATP, Université de Provence, Marseille PROGRAM COMMITTEE: Program chairs • Yonina Eldar (Electrical Engineering, Technion, Israel Institute of Technology) • Karlheinz Gröchenig (Fakultät für Mathematik, University of Vienna) • Sinan Gunturk (Mathematics Department, Courant Institute, New York) • Michael Unser (Biomedical Imaging Group, EPFL Lausanne) Special sessions organizers • Bernhard Bodmann (Dept of Mathematics, University of Houston, USA) • Pierluigi Dragotti (Dept of Electronic and Alectrical Engineering, Imperial College London, UK) • Yonina Eldar (Electrical Engineering, Technion, Israel Institute of Technology, Israel) • Laurent Fesquet (TIMA, INP Grenoble, France) • Massimo Fornasier (RICAM, Linz University, Austria) • Hakan Johansson (Dept of Electrical Engineering, Linkoping University, Sweden) • Gitta Kutyniok (Universität Osnabrück, Germany) • Pina Marziliano (Nanyang Technological University, Singapore) • Götz Pfander (International University Bremen, Germany) • Hölger Rauhut (Hausdorff Center for Mathematics, University of Bonn, Germany) • Jared Tanner (School of Mathematics, University of Edimburgh, Scotland) • Christian Vogel (ISI, ETH Zurich, Switzerland) • Ozgur Yilmaz (Dept of Mathematics, University of British Columbia, Vancouver, Canada)
Poly(ADP-Ribose) Polymerase Activity and Coronary Artery Disease in Type 2 Diabetes Mellitus (2020)

Greater PARP activity may have causal roles in the development of obstructive CAD among patients with diabetes mellitus.
Femtosecond symmetry breaking and coherent relaxation of methane cations via x-ray spectroscopy (2023)

Understanding the relaxation pathways of photoexcited molecules is essential to gain atomistic-level insight into photochemistry. We performed a time-resolved study of ultrafast molecular symmetry breaking through geometric relaxation (Jahn-Teller distortion) on the methane cation. Attosecond transient absorption spectroscopy with soft x-rays at the carbon K-edge revealed that the distortion occurred within 10 ± 2 femtoseconds after few-femtosecond strong-field ionization of methane. The distortion activated coherent oscillations in the asymmetric scissoring vibrational mode of the symmetry-broken cation, which were detected in the x-ray signal. These oscillations were damped within 58 ± 13 femtoseconds because vibrational coherence was lost with the energy redistributing into lower-frequency vibrational modes. This study completely reconstructs the molecular relaxation dynamics of this prototypical example and opens avenues for exploring complex systems.
Morphological characteristics of the developing human brain during the embryonic period (1997)

Many features of the developing nervous system are visible from external observations of intact human embryos. In this study, a photographic atlas from the 4th to the 7th week after ovulation (Carnegie stages 10-18) is provided. The neural folds began to fuse at stage 10, and the rostral and caudal neuropore were closed during stages 11 and 12, respectively. The three primary divisions of the brain were distinguishable before closing of the neural tube. The five secondary brain vesicles were formed during stages 14-15. The development of the cerebellum and cerebrum were first observed at stages 14 and 15, respectively. The mesencephalic flexure was seen at stage 12, and the cervical flexure and pontine flexure at stage 14. After stages 18-19, it became increasingly difficult to identify detailed features of the brain from the surface. Results from this study will help to correlate the characteristic findings of the developing central nervous system of human embryos from stereomicroscopical and light microscopical observations and to locate the exact parts of the developing human brain for other purposes.
Evolution of the vacuum Rabi peaks in a detuned atom-cavity system (1997)

We measure the transmission spectrum of an optical cavity filled with two-level atoms. For small intensities, the coupling between atoms and a single mode of the cavity splits the spectrum into two normal modes: the vacuum Rabi peaks. We gradually decouple the system in two ways and study the evolution of the vacuum Rabi peaks. First we lower the atom-cavity coupling frequency through its intensity dependence, showing that the peaks shift, deform, exhibit frequency hysteresis, and eventually merge into a single peak that approaches the empty cavity resonance. Second we detune the atoms and the cavity mode and observe an avoided crossing. The normal modes of the coupled system transform into the two resonances of the uncoupled system. We map out the transition region and find good agreement with theoretical predictions.
Tissue-Adhesive Paint of Silk Microparticles for Articular Surface Cartilage Regeneration (2020)

Current biomaterials and tissue engineering techniques have shown a promising efficacy on full-thickness articular cartilage defect repair in clinical practice. However, due to the difficulty of implanting biomaterials or tissue engineering constructs into a partial-thickness cartilage defect, it remains a challenge to provide a satisfactory cure in joint surface regeneration in the early and middle stages of osteoarthritis. In this study, we focused on a ready-to-use tissue-adhesive joint surface paint (JS-Paint) capable of promoting and enhancing articular surface cartilage regeneration. The JS-Paint is mainly composed of <i>N</i>-(2-aminoethyl)-4-(4-(hydroxymethyl)-2-methoxy-5-nitrosophenoxy) butanamide (NB)-coated silk fibroin microparticles and possess optimal cell adhesion, migration, and proliferation properties. NB-modified silk fibroin microparticles can directly adhere to the cartilage and form a smooth layer on the surface via the photogenerated aldehyde group of NB reacting with the -NH<sub>2</sub> groups of the cartilage tissue. JS-Paint treatment showed a significant promotion of cartilage regeneration and restored the smooth joint surface at 6 weeks postsurgery in a rabbit model of a partial-thickness cartilage defect. These findings revealed that silk fibroin can be utilized to bring about a tissue-adhesive paint. Thus, the JS-Paint strategy has some great potential to enhance joint surface regeneration and revolutionize future therapeutics of early and middle stages of osteoarthritis joint ailments.
Phase-coherent quantum mechanical spin transport in a weakly disordered quasi-one-dimensional channel (2004)

A transfer matrix technique is used to model phase-coherent spin transport in the weakly disordered quasi-one-dimensional channel of a gate-controlled electron spin interferometer [S. Datta and B. Das, Appl. Phys. Lett. 56, 665 (1990)]. The model includes the effects of an axial magnetic field in the channel of the interferometer (caused by the ferromagnetic contacts), a Rashba spin-orbit interaction, and elastic (nonmagnetic) impurity scattering. We show that in the presence of an axial magnetic field, nonmagnetic impurities can cause spin relaxation in a manner similar to the Elliott-Yafet mechanism. The amplitudes and phases of the conductance oscillations of the interferometer and the degree of spin-conductance polarization are found to be quite sensitive to the height of the interface barrier at the contact, as well as the strength, locations, and nature (attractive or repulsive) of just a few elastic nonmagnetic impurities in the channel. This can seriously hinder practical applications of spin interferometers.