gebhart/patrepeval huggingface dataset:
.beta.-Stannyl Allylic Alcohols through Photooxygenation (Schenck Reaction) of Vinylstannanes and Reduction of the Resulting Allylic Hydroperoxides: Synthesis and Selected Transformations (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.beta.-Stannyl Allylic Alcohols through Photooxygenation (Schenck Reaction) of Vinylstannanes and Reduction of the Resulting Allylic Hydroperoxides: Synthesis and Selected TransformationsWaldemar Adam and Peter KlugCite this: J. Org. Chem. 1994, 59, 10, 2695–2699Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/jo00089a010https://doi.org/10.1021/jo00089a010research-articleACS PublicationsRequest reuse permissionsArticle Views228Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Strength and microstructure analysis of concrete containing rice husk ash under seawater attack by wetting and drying cycles (2013)

Concrete containing rice husk ash (RHA), subjected to seawater under wetting and drying cycles, was studied through an investigation of the compressive strength and microstructure of various types of blended cement paste. Five levels of cement replacement (0%, 10%, 20%, 30% and 40% by weight) were studied. The total cementitious content used was 420 kg/m 3 . A water/binder ratio of 0·49 was used to produce concrete with a target strength of 40 MPa at age 28 days. The performance of blended cement concrete was evaluated based on compressive strength and chloride ion permeability. Microstructural changes in the specimens were determined by differential thermal analysis, X-ray diffraction and scanning electron microscopy. The addition of RHA was found to decrease calcium hydroxide formation by hydration and, consequently, gypsum and ettringite were reduced during seawater attack. RHA at 40% cement replacement improved resistance to seawater attack and effectively decreased ettringite and gypsum formations.
Effects of N-(4-Hydroxyphenyl)retinamide on Vitamin A Metabolism in Rats (1995)

Chronic administration of the anticancer drug N-(4-hydroxyphenyl)-retinamide (4-HPR) causes reductions in the plasma levels of vitamin A and its transport protein, retinol-binding protein. Here, we used model-based compartmental analysis to study effects of 4-HPR on the whole-body kinetics of vitamin A metabolism in rats. Rats (n = 8) were fed a purified diet containing vitamin A (approximately 49 nmol retinol/day) plus 0 or approximately 50 mumole 4-HPR/(kg body wt.day). Plasma retinol kinetics were monitored for 35 days after intravenous administration of [3H]retinol-labeled plasma. 4-HPR caused an 80% reduction in plasma retinol; after 40 days of treatment with 4-HPR, liver vitamin A levels were 2.33 times higher than those of control rats. A three compartment model, in which plasma retinol exchanges with two extravascular compartments, was required to fit data for both groups. Vitamin A input was via the central plasma compartment, while irreversible loss was via the larger extravascular compartment. The time retinol spent in plasma before reversible or irreversible exit was normal (1.7 hr) in 4-HPR-treated rats, but the rate of plasma retinol turnover was reduced, and the recycling of retinol to plasma was delayed and reduced. Vitamin A utilization was significantly lower in 4-HPR-treated rats (20 nmol retinol/day vs 42 nmol/day in controls). We conclude that 4-HPR partially blocks access and thus binding of retinol to retinol-binding protein and may therefore lead to vitamin A accumulation in certain cells.
Proposed Criteria for Low Frequency Industrial Noise in Residential Communities (2005)

There is a need in the United States for some Federal or prominent standards organization to publish limits in residential areas for low frequency noise attributable to industrial sources. This paper proposes maximum limits based on experience in investigating and solving low frequency noise problems, principally from open cycle combustion turbine installations The author believes the recommended C-weighted limits in this paper are applicable to most common steady low-frequency noise sources in addition to combustion turbines due to the combined tonal and broadband character of the sound. It is hoped standardizing bodies can add this reference to the larger body of literature to arrive at a workable sorely-needed standard.
Comparison of risk assessment in 1652 early ER positive, HER2 negative breast cancer in a real-world data set: classical pathological parameters vs. 12-gene molecular assay (EndoPredict) (2021)

In this study we could show that EP risk scores are distributed differentially among Ki67 expression groups, especially in Ki67 low and high tumors with a substantial proportion of patients with EPclin high risk results in Ki67 low tumors and vice versa. This suggests that classical pathological parameters and gene expression parameters are not interchangeable, but should be used in combination for risk assessment.
Effects of electric field and poling on the response of multilayer piezoelectric film actuators with partial electrodes (2008)

The electromechanical field concentrations due to surface and internal electrodes in multilayer piezoelectric film actuators are investigated through numerical and experimental characterization. A nonlinear finite element analysis is carried out to discuss the effects of electric field and poling on the displacement and internal electromechanical fields in fully and partially poled piezoelectric actuators, by introducing models for polarization switching. Displacement measurements are also performed for the actuators, and a comparison of the predictions with experimental data is conducted.
Surface Transfer p-Type Doping of Epitaxial Graphene (2007)

Epitaxial graphene thermally grown on 6H-SiC(0001) can be p-type doped via a novel surface transfer doping scheme by modifying the surface with the electron acceptor, tetrafluoro-tetracyanoquinodimethane (F4-TCNQ). Synchrotron-based high-resolution photoemission spectroscopy reveals that electron transfer from graphene to adsorbed F4-TCNQ is responsible for the p-type doping of graphene. This novel surface transfer doping scheme by surface modification with appropriate molecular acceptors represents a simple and effective method to nondestructively dope epitaxial graphene for future nanoelectronics applications.
Auditory Characteristics and Background Factors in Listening Difficulties (2022)

日常生活において, 複数人数での会話, 周囲に雑音がある中での会話, 電話での会話などで聞き取りが困難である場合, 難聴の自覚をもって耳鼻咽喉科を受診する. しかし聴覚検査で正常と診断される例では, 本人の聞こえの感じ方と検査結果に解離が見られ, 特にこのような聞こえの困難を自覚する例では聴覚情報処理障害が疑われる. しかし明確な診断基準がないためその診断には苦慮する. 今回そのような聞き取り困難例に対して聴覚心理・認知的検査の側面と背景要因の側面から検討を行った.
SPARSKIT: A basic tool kit for sparse matrix computations (1990)

Presented here are the main features of a tool package for manipulating and working with sparse matrices. One of the goals of the package is to provide basic tools to facilitate the exchange of software and data between researchers in sparse matrix computations. The starting point is the Harwell/Boeing collection of matrices for which the authors provide a number of tools. Among other things, the package provides programs for converting data structures, printing simple statistics on a matrix, plotting a matrix profile, and performing linear algebra operations with sparse matrices.
The Effects of Hull Pitching Motions and Waves on Periodic Propeller Blade Loads. (1982)

Abstract : Fundamental investigations were made of the effects of periodic hull pitching motions and waves on the periodic loads on propeller blades and bearings. These periodic loads were measured during carefully controlled model experiments in which the periodic hull pitching motions, regular waves, and relative phase of the hull pitching to the wave encounter were systematically and independently varied. The periodic blade loads were calculated using trochoidal wave velocity profiles, and representation of the propeller based on a quasi-steady method. The results of both theory and experiment show significant modulation of the amplitudes of the periodic blade loads with hull pitching motions and wave frequency of encounter. The influence of the hull significantly modifies the amount of modulation of the shaft frequency loads due to both the periodic vertical motion of the propeller and the trochoidal wave velocity profile in the absence of the hull. Therefore, for engineering purposes, the modulation of blade loads due to waves and hull motions for transom type hulls can be estimated by simple trochoidal wave velocity profiles, quasi-steady propeller theory, and constant multiples derived from the experiments presented in this paper.
Impact of interfacial misfit dislocation growth mode on highly lattice-mismatched InxGa1-xSb epilayer grown on GaAs substrate by metalorganic chemical vapor deposition (2016)

Highly lattice-mismatch (over 8%) ternary InxGa1-xSb alloy directly grown on GaAs substrates was demonstrated by metalorganic chemical vapor deposition (MOCVD). The influence of growth parameters, such as growth temperature, indium vapor composition, and V/III ratio, on the film properties was investigated, and it was found that the growth temperature has the strongest effect on the surface morphology and the crystal quality of the InxGa1-xSb epilayer. An optimized growth temperature of ∼590 °C and a V/III ratio of 2.5 were used for the growth of the InxGa1-xSb epilayer on GaAs that displays a lower surface roughness. High-resolution transmission electron microscopy micrographs exhibit that InxGa1-xSb epilayer growth on GaAs was governed by the interfacial misfit dislocation growth mode. Furthermore, the variation of the intermixing layer thickness at the InxGa1-xSb/GaAs heterointerface was observed. These results provide an information of growing highly lattice-mismatched epitaxial material systems by MOCVD growth process.
Parallel random number generators in Monte Carlo derivative pricing: An application-based test (2012)

Parallel pseudorandom number generators (PPRNG) that satisfy classical statistical tests may still demonstrate intra-stream and inter-stream correlations in real life applications. In order to investigate the suitability of a PPRNG for use in Monte Carlo pricing of financial derivatives, an application-based test is proposed to evaluate the bias and the standard error of the mean (SE) associated with the PPRNG as a gauge of intra-stream and inter-stream correlations respectively. This test involves estimating the price of a vanilla European call option via Monte Carlo simulation, where the asset price at maturity is estimated by propagating the Black–Scholes stochastic differential equation via the Euler–Maruyama discretization scheme. The mean and SE profiles of the numerical results based on three PPRNG libraries (RngStream, TRNG and SPRNG) that implement parallel random numbers via sequence splitting strategies (RngStream and TRNG) and parameterization strategy (SPRNG) are compared. In terms of the bias and SE profiles, the best performing PPRNG constructed using the sequence splitting strategy is comparable to that constructed using parameterization, both use multiple recursive generators in their kernel.
Facile Exfoliation of Single‐Crystalline Copper Alkylphosphates to Single‐Layer Nanosheets and Enhanced Supercapacitance (2019)

Manipulation of low-dimensional solids through soft chemical routes is an elegant way to realize newer materials. A new family of single-crystalline transition-metal layered organophosphates, with about 185 000 metal phosphate layers in a single crystal, can be exfoliated to a single-layer nanosheet by a facile and rapid solvent assisted method. This exfoliation aids the formation of high-surface-area pyrophosphates with enhanced supercapacitance.
MCL1 Haploinsufficiency Protects Mice From MYC-Induced Acute Myeloid Leukemia. (2009)

Abstract Abstract 764 Anti-apoptotic Bcl2 family genes have been implicated in the pathogenesis of acute myelogenous leukemia (AML), but the functional significance and relative importance of individual proteins (i.e. BCL2, BCL-XL, MCL1) remains poorly understood. We examined the expression of BCL2, BCL-X and MCL1 in primary human hematopoietic subsets and in leukemic blasts from AML patients, and found MCL1 transcripts were consistently expressed at high levels in all samples tested (100%, n=111). Mcl1 protein was also consistently expressed at high levels in myeloid leukemic blasts in a murine Myc-induced AML model, and we used this model to test the hypothesis that Mcl1 facilitates AML development by allowing myeloid progenitor cells to evade oncogene-induced cell death. Activation of Myc for seven days in vivo substantially increased myeloid lineage cells while hematopoietic stem, progenitor and B-lineage cells were depleted. Haploinsufficiency for Mcl1 (Mcl1flox/null) abrogated the development of AML (median survival 56 days vs. not reached), and deletion of a single allele of Mcl1 from fully transformed AML cells significantly prolonged the survival of transplanted mice. In contrast, the rapid lethality of disease (median survival 25 days) was restored by co-expression of Bcl2 with Myc in Mcl1flox/null cells. Together, these data demonstrate a critical and dose-dependent role for Mcl1 in AML pathogenesis and suggest that Mcl1 may be an ideal therapeutic target in patients with de novo AML. Disclosures: DiPersio: Genzyme: Honoraria.
TIGRINA d, required for regulating the biosynthesis of tetrapyrroles in barley, is an ortholog of the FLU gene of Arabidopsis thaliana1 (2003)

Regulation of tetrapyrrole biosynthesis in higher plants has been attributed to negative feedback control of steps prior to delta-aminolevulinic acid (ALA) formation. One of the first mutants with a defect in this control had been identified in barley. The tigrina (tig) d mutant accumulates 10-15-fold higher amounts of protochlorophyllide than wild type, when grown in the dark. The identity of the TIGRINA d protein and its mode of action are not known yet. Initially this protein had been proposed to act as a repressor of genes that encode enzymes involved in early steps of ALA formation, but subsequent attempts to confirm this experimentally failed. Here we demonstrate that the TIGRINA d gene of barley is an ortholog of the FLU gene of Arabidopsis thaliana. The FLU protein is a nuclear-encoded plastid protein that plays a key role in negative feedback control of chlorophyll biosynthesis in higher plants. Sequencing of the FLU gene of barley revealed a frame shift mutation in the FLU gene of the tig d mutant that results in the loss of two tetratricopeptide repeats that in the FLU protein of Arabidopsis are essential for its biological activity. This mutation cosegregates strictly with the tigrina phenotype within the F1 population of a heterozygous tig d mutant, thus providing additional support for the flu gene being responsible for the tigrina phenotype of barley.
Analytical Quality by Design, Life Cycle Management, and Method Control (2022)

Analytical methods are utilized throughout the biopharmaceutical and vaccines industries to conduct research and development, and to help control manufacturing inputs and outputs. These analytical methods should continuously provide quality data to support decisions while managing the remaining of risk and uncertainty. Analytical quality by design (AQbD) can provide a systematic framework to achieve a continuously validated, robust assay as well as life cycle management. AQbD is rooted in ICH guidelines Q8 and Q9 that were translated to the analytical space through several white papers as well as upcoming USP 1220 and ICH Q14. In this white paper, we expand on the previously published concepts of AQbD by providing additional context for implementation in relation to ICH Q14. Using illustrative examples, we describe the AQbD workflow, its relation to traditional approaches, and potential pathways for ongoing, real-time verification. We will also discuss challenges with respect to implementation and regulatory strategies.
Neurography of the pudendal nerve in pudendal canal syndrome (1999)

Jost, W. H. M.D.1; Duschka, L. M.D.1; Herold, A. M.D.1; Müller-Lobeck, H. M.D.1; Stadelmaier, U. M.D.2; Matzel, K. E. M.D.2 Author Information
Antitumor Responses Stimulated by Dendritic Cells Are Improved by Triiodothyronine Binding to the Thyroid Hormone Receptor β (2015)

Bidirectional cross-talk between the neuroendocrine and immune systems orchestrates immune responses in both physiologic and pathologic settings. In this study, we provide in vivo evidence of a critical role for the thyroid hormone triiodothyronine (T3) in controlling the maturation and antitumor functions of dendritic cells (DC). We used a thyroid hormone receptor (TR) β mutant mouse (TRβPV) to establish the relevance of the T3-TRβ system in vivo. In this model, TRβ signaling endowed DCs with the ability to stimulate antigen-specific cytotoxic T-cell responses during tumor development. T3 binding to TRβ increased DC viability and augmented DC migration to lymph nodes. Moreover, T3 stimulated the ability of DCs to cross-present antigens and to stimulate cytotoxic T-cell responses. In a B16-OVA mouse model of melanoma, vaccination with T3-stimulated DCs inhibited tumor growth and prolonged host survival, in part by promoting the generation of IFNγ-producing CD8(+) T cells. Overall, our results establish an adjuvant effect of T3-TRβ signaling in DCs, suggesting an immediately translatable method to empower DC vaccination approaches for cancer immunotherapy.
<title>Chemical-mechanical polishing: enhancing the manufacturability of MEMS</title> (1996)

The planarization technology of chemical-mechanical- polishing (CMP), used for the manufacturing of multilevel metal interconnects for high-density integrated circuits, is also readily adaptable as an enabling technology in micro- electro-mechanical systems (MEMS) fabrication, particularly polysilicon surface micromachining. CMP not only eases the design and manufacturability of MEMS devices by eliminating several photolithographic and film issues generated by severe topography, but also enables far greater flexibility with process complexity and associated designs. Thus, the CMP planarization technique alleviates processing problems associated with fabrication of multilevel polysilicon structures, eliminates design constraints linked with non- planar topography, and provides an avenue for integrating different process technologies. Examples of these enhancements include: a simpler extension of surface micromachining fabrication to multiple mechanical layers, a novel method of monolithic integration of electronics and MEMS, and a novel combination of bulk and surface micromachining.
Epifluorescence surveys of extreme environments using PanCam imaging systems: Antarctica and the Mars regolith (2008)

Rapid discovery of the distribution and relative abundance of organic material without sample destruction or the expenditure of irreplaceable resources is one of the primary requirements for exploration of novel extreme environments both in remote locations on Earth and on the Mars regolith. A wide variety of organic and biogenic molecular targets including polycyclic aromatic hydrocarbons, aromatic amino acids, nucleic acids, photosynthetic pigments, and critical metabolic components such as flavin adenine dinucleotide and nicotinamide adenine dinucleotide exhibit strong, distinctive fluorescent signatures following excitation by ultraviolet (UV) light sources. These fluorescence signatures are easily imaged with camera systems currently employed on Mars rovers and imaging equipment available during human or robotic exploration of remote extreme environments on Earth. In this paper we discuss recent results with epifluorescent imaging of organic and biological targets using filter bands comparable to those available to ExoMars and review plans for epifluorescence surveys of the Dry Valleys of Eastern Antarctica including the Schirmacher Oasis and the perennially ice-covered, merimictic, oligotrophic Lake Untersee.
Disruption of the genomic imprint in trans with homologous recombination at Snrpn in ES cells (2003)

In gene targeting studies of the Prader-Willi syndrome (PWS)/Angelman syndrome (AS) domain in mouse ES cells, we recovered only recombinants with the paternal allele for constructs at exons 2 or 3 of the imprinted, maternally silenced Snurf-Snrpn gene. These sites lie close to the imprinting center (IC) for this domain. In contrast, recombinants for Ube3a within the same imprinted domain were recovered with equal frequency on the maternal and paternal alleles. In addition, gene targeting of the paternal allele for Snurf-Snrpn resulted in partial or complete demethylation in trans with activation of expression for the previously silenced maternal allele. The imprint switching of the maternal allele in trans is not readily explained by competition for trans-acting factors and adds to a growing body of evidence indicating homologous association of oppositely imprinted chromatin domains in somatic mammalian cells.
Flüchtige Metallalkoxide nach dem Konzept der Donorfunktionalisierung (1995)

Abstract Metallalkoxide bestechen seit den grundlegenden Arbeiten von D. C. Bradley und R. C. Mehrotra durch eine Vielfalt an nieder‐ und hochmolekularen Strukturen; darüber hinaus gewinnen sie als Einsatzstoffe bei der Lösung materialtechnischer Probleme zunehmend an Interesse. Das Verständnis des hydrolytischen Nucleationsverhaltens ist eine Voraussetzung für die Optimierung von Materialien aus Sol‐Gel‐Prozessen. Will man Metallalkoxide als Vorstufen in CVD‐Prozessen (CVD = chemical vapor deposition) für die Herstellung oxidischer anorganischer Materialien nutzen, so ist allerdings eine hinreichende Flüchtigkeit und zersetzungsfreie Sublimation bei möglichst niedriger Temperatur ( ⩽150 °C) nötig. Erst in jüngster Zeit wurde hier mit dem Konzept der Donorfunktionalisierung systematisch ein Typ von Liganden entwickelt, der die Vorteile von sterischem Anspruch und σ‐Donor‐Stabilisierung in sich vereinigt und damit niedermolekulare Metallalkoxide stabilisiert. Mit ihnen bilden selbst große Metall‐Ionen niedriger Ladung (Ba 2+ ) flüchtige Alkoxide. O‐ und N‐Donorfunktionen in zwei‐ und mehrzähnigen Alkoxoliganden sind besonders vorteilhaft; z.B. ist der Vanadiumkomplex [V(OCMe 2 CH 2 OMe) 3 ] eines der flüchtigsten Metallalkoxide. Erste unzersetzt sublimierbare Alkoxide der Erdalkalimetalle Calcium, Strontium und Barium haben die Formel [M 2 {OC(CH 2 O i Pr) 2 t Bu} 4 ]. Der vorliegende Aufsatz bietet eine kritische Bestandsaufnahme der Metallalkoxide unter dem Aspekt der Flüchtigkeit, beschreibt Erfolge des Konzepts der Donorfunktionalisierung und zeigt perspektivisch auf, wie man Alkoxoliganden durch Weiterentwicklung dieses Konzepts Metallen nach Maßgabe ihrer Ladungs‐Radien‐Verhältnisse „auf den Leib schneidern”︁ kann.