gebhart/patrepeval huggingface dataset:
Cell-Free RNA Content in Peripheral Blood as Potential Biomarkers for Detecting Circulating Tumor Cells in Non-Small Cell Lung Carcinoma (2016)

Circulating tumor cells (CTCs) have been implicated in tumor progression and prognosis. Techniques detecting CTCs in the peripheral blood of patients with non-small cell lung carcinoma (NSCLC) may help to identify individuals likely to benefit from early systemic treatment. However, the detection of CTCs with a single marker is challenging, owing to low specificity and sensitivity and due to the heterogeneity and rareness of CTCs. Herein, the probability of cell-free RNA content in the peripheral blood as a potential biomarker for detecting CTCs in cancer patients was investigated. An immunomagnetic enrichment of real-time reverse-transcription PCR (RT-PCR) technology for analysis of CTCs in NSCLC patients was also developed. The mRNA levels of four candidate genes, cytokeratin 7 (<i>CK7</i>), E74-like factor 3 (<i>ELF3</i>), epidermal growth factor receptor (<i>EGFR</i>), and erythropoietin-producing hepatocellular carcinoma receptor B4 (<i>EphB4</i>) that were significantly elevated in tumor tissues and peripheral blood mononuclear cells (PBMCs) were determined. The expression of <i>CK7</i> and <i>ELF3</i> in tumor tissues and <i>EGFR</i> in PBMCs was associated with lymph node metastasis (all <i>p</i> < 0.05). The expression of <i>CK7</i> in PBMCs was correlated with age and <i>EphB4</i> in PBMCs correlated with histopathological type, respectively (all <i>p</i> < 0.05). The expression of all four genes in tumor tissues and PBMCs was significantly correlated with the clinical stage (all <i>p</i> < 0.01). Survival analysis showed that the patients with enhanced expression of <i>CK7</i>, <i>ELF3</i>, <i>EGFR</i>, and <i>EphB4</i> mRNA in PBMCs had poorer disease-free survival (DFS) and overall survival (OS) than those without (all <i>p</i> < 0.0001). The present study showed that this alteration of cell-free RNA content in peripheral blood might have clinical ramifications in the diagnosis and treatment of NSCLC patients.
An interlaboratory comparison of methods used to assess antioxidant potentials1 (2006)

Many analytical methods are used to measure the antioxidative activity of substances yet little is known about the comparability of the test results between laboratories. After an initial evaluation of a broad range of methods conducted by one laboratory, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, the trolox equivalent antioxidant capacity (TEAC) assay, the lipid assay (or 2,2'-azobis(2-aminepropane) (ABAP) assay) and the thiobarbituric acid (TBA) assay were selected to be evaluated in the interlaboratory study. The antioxidative potentials of trolox, tocopherol, lipochroman-6, ascorbic acid, 4-methyl-brenzcatechin, and/or 3,5-di-tert-butyl-4-hydroxytoluene (BHT) were assessed using each of the methods. These methods were then evaluated in respect of their reproducibility and classification properties. Based on the results of this study, the DPPH assay followed by the TEAC assay yielded the best results based on reproducibility and sensitivity both within one laboratory and between laboratories. The results of the interlaboratory study were then compared with the single center results obtained from the commercially available photochemolumiescence (PCL) kit. To assess the transferability of chemical data to biological systems, they were also compared with the single center results obtained using the cell-based Dichlorodihydrofluoresceine (DCFH) assay.
CD34 expression is regulated reciprocally with adhesion molecules in vascular endothelial cells in vitro (1993)

Freshly cultured vascular endothelial cells express the CD34 antigen in a diffuse cell surface pattern with some concentration on microvilli. Expression is downregulated with proliferation in continuous culture and undetectable after nine population doublings but can be maintained by restraining cell proliferation and promoting cell contact. Expression of CD34 at the antigen and mRNA levels on early passage cells is rapidly downregulated by interleukin-1 beta (IL-1 beta), interferon-gamma (INF-gamma), and tumor necrosis factor-alpha (TNF-alpha) under conditions in which these ligands upregulate the adhesion molecules: endothelial leukocyte adhesion molecule 1 (ELAM-1) and intracellular adhesion molecule 1 (ICAM-1). This reciprocal pattern of expression and the topographic distribution of CD34 molecules on the lumenal interdigitated microprocesses of adjacent endothelial cells in vivo suggest that CD34 might have a negative modulating role on adhesion functions of endothelia.
On blockchain-based anonymized dataset distribution platform (2017)

In this paper, we design a distributed platform for anonymized dataset trading without any centralized trusted third party. The platform consists of peers and consensus-based blockchain mechanism, and each peer acts as a data broker, data receiver, or verifier for blockchain in a data transfer transaction. A data broker collects data from data owners under their consent for data trading. The Privacy Policy Manager (PPM) manages the consent information and confirms them on behalf of data owners, when data distribution is requested from data broker. We implement a prototype system of the platform using an open-source blockchain mechanism, Hyperledger Fabric, and provide evaluation results of the prototype system.
Numerical evaluation of the kidney invasion test. (1987)

We have implanted MO4 transformed mouse cells attached to a collagen matrix (artificial tumor) under the renal capsule of syngeneic mice. It was our purpose to evaluate whether or not the kidney invasion test (KIT) could be used for the determination in vivo of the invasive capacity of cultured cell populations. Invasion was expressed in terms of the proportion of the depth of the invasive part of the tumor to the total tumor thickness (invasion rate), both measured macroscopically after hemisection of the kidney. Macroscopic findings were confirmed by histology. For MO4 cells the invasion index changed in function of time after implantation. The relationship 'invasion index versus time after implantation' was demonstrated to be constant in 3 independent groups of mice. Therefore, we propose determination of the invasion rate versus time in the KIT as a method to compare the invasive capacity in vivo of different cell lines.
Réévaluation du test de compression diamétrale comme test de rupture pour comprimé pharmaceutique : introduction de méplats et de défauts de taille contrôlée (2017)

Colloque avec actes et comité de lecture. Internationale.
Anti-Mullerian Hormone Is a Sensitive Serum Marker for Gonadal Function in Women Treated for Hodgkin’s Lymphoma during Childhood (2007)

Women treated during childhood for HL with MOPP seem to have a distinctly lower ovarian reserve as measured by lower AMH values at early adulthood, compared with healthy women. Moreover, AMH seems to be the only predictor that is sufficiently sensitive to detect this decrease in ovarian reserve.
A coherent nuclear quadrupole pulse and double resonance spectrometer (1983)

A coherent pulse and double resonance NQR spectrometer system, for investigations in the pure quadrupole regime, has been described. The pulsed NQR spectrometer is capable of operation typically over the range of 10-40 MHz and can be adapted with ease for spin echo investigations, relaxation time measurements and double resonance experiments such as spin echo double resonance (SEDOR) and double resonance in the rotating frame (DRRF). Besides the Hartmann and Hahn DRRF scheme, a DRRF scheme involving off-resonance irradiation of the abundant spins can also be implemented. To simplify construction, commercially available devices have been extensively incorporated into the spectrometer system. The general features of the spectrometer are presented and the performance is illustrated by a few typical signal recordings.
Structure and transport properties of Ga-doped semi- and polycrystalline Si/sub 1-x/Ge/sub x/ films (2002)

Polycrystalline SiGe films have applications in solar cells, thermoelectrical devices and field-effect transistors for large area integration (liquid crystal displays etc.). Recently, a nanocrystalline state was detected by us in heavily B-doped SiGe films after vacuum annealing. Amorphous (a) Si/sub 1-x/Ge/sub x/ films with x=0.25-0.60, about 200-300 nm thick and heavily doped with Ga (1%), were deposited by molecular beam on SiO/sub 2//Si[001] substrates at room temperature. For crystallization, a-SiGe/SiO/sub 2//Si structures were annealed in vacuum of 10/sup -6/ Torr at 600 to 900/spl deg/C. X-ray diffraction and TEM observations in situ showed nanocrystalline (nc) structure in SiGe films with grain size of about 5-20 nm. The nc-Si/sub 1-x/Ge/sub x/ films demonstrated high hole mobility (1 to 100 cm/sup 2//Vs) and Seebeck coefficient values (5 to 110 /spl mu/V/K).
Greenhouse Evaluation of Products That Induce Host Resistance for Control of Scab, Melanose, and Alternaria Brown Spot of Citrus (2003)

Products that induce disease resistance in plants were evaluated on potted seedlings of rough lemon for citrus scab, caused by Elsinoe fawcettii; grapefruit for melanose, caused by Diaporthe citri; and Dancy tangerine for Alternaria brown spot caused by Alternaria alternata pv. citri. Plants were pruned to a single stem with mature leaves and treated at bud break or various times thereafter. New foliage was inoculated and subsequently evaluated for disease severity. Oxycom, Nutriphite, Messenger, Goemar H11, Serenade, ReZist, ProPhyt, Aliette, Actigard, and KeyPlex were evaluated and compared with benomyl or strobilurin fungicides as standards. Most products reduced disease severity compared with the untreated control, but were less effective than standard fungicides. The most generally effective products were ReZist and Actigard, those that contain or produce phosphorous acid (Aliette and Nutriphite), and a bacterial preparation (Serenade). Oxycom and Messenger controlled scab well in some tests. Products that induce host resistance may be useful for disease control in citrus in an integrated program with standard fungicides.
Comparison of 3D OS-EM and 4D MAP-RBI-EM Reconstruction Algorithms for Cardiac Motion Abnormality Classification Using a Motion Observer (2010)

Using a heart motion observer, we compared the performance of two image reconstruction techniques, a 3D OS-EM algorithm with post Butterworth spatial filtering and a 4D MAP-RBI-EM algorithm. The task was to classify gated myocardial perfusion (GMP) SPECT images of beating hearts with or without regional motion abnormalities. Noise-free simulated GMP SPECT projection data was generated from two 4D NCAT beating heart phantom models, one with normal motion and the other with a 50% motion defect in a pie-shaped wedge region-of-interest (ROI) in the anterior-lateral left ventricular wall. The projection data were scaled to clinical GMP SPECT count level before Poisson noise was simulated to generate 40 noise realizations. The noise-free and noisy projection data were reconstructed using the two reconstruction algorithms, parameters chosen to optimize the tradeoff between image bias and noise. As a motion observer, a 3D motion estimation method previously developed was applied to estimate the radial motion on the ROI from two adjacent gates. The receiver operating characteristic (ROC) curves were computed for radial motion magnitudes corresponding to each reconstruction technique. The area under the ROC curve (AUC) was calculated as an index for classification of regional motion. The reconstructed images with better bias and noise tradeoff were found to offer better classification for hearts with or without regional motion defects. The 3D cardiac motion estimation algorithm, serving as a heart motion observer, was better able to distinguish the abnormal from the normal regional motion in GMP SPECT images obtained from the 4D MAP-RBI-EM algorithm than from the 3D OS-EM algorithm with post Butterworth spatial filtering.
Lesion detection in dermatoscopic images using anisotropic diffusion and morphological flooding (2003)

A new technique for the unsupervised detection of multiple objects in noisy background is presented in this paper, with application to digitized dermatoscopic images. The proposed method uses anisotropic diffusion in the L*u*v* uniform color space to suppress background noise and spurious structures while preserving the object boundaries. A simple and fast hair removal scheme based on morphological operators and luminance thresholding is also introduced for the application to pigmented skin lesions. The luminance component is then used to extract iso-level closed contours by morphological flooding. These curves are considered as contour candidates and the selection is based on the minimization of a gradient based energy functional. The main advantages of this technique is the low processing time and the possibility, if necessary, to scroll through the different level curves without additional processing.
Prenatal diagnosis of a 46,XY karyotype female fetus with an SRY-associated gonadal dysgenesis, conceived through an intracytoplasmic sperm injection: a case report (2022)

Oligozoospermic patients planning assisted reproduction are warranted to undergo genetic counselling and testing for possible inherited and mosaic mutations, and risk factors for de novo mutations.
Optimization of Processing Conditions and Mechanical Properties in Polymer Nanocomposite (2007)

Nanocomposites are used as a new class of polymer system and many researchers have been interested in the clay nanocomposite because of its good mechanical properties, heat resistance, flame retardancy, and barrier property. Modified layered silicates as fillers are dispersed at a nanometer-level within a polymer matrix and then new extraordinary properties are observed. In this study, polypropylene/clay nanocomposites were prepared in a twin screw extruder by the melt compounding method. In order to increase the compatibility of PP with the clay, the MAPP was used as a compatibilizer. And organic modified clays were used as a nanometric filler during the melt extrusion. Through the analysis of SAXS, WAXS, the dispersion of clay was investigated. These nanocomposites compared with a neat polypropylene/talc composite have high modulus, low toughness, and reduced shrinkage at the stable dispersion.
ChemInform Abstract: Fundamental and Applied Properties of Borocations (2016)

Abstract Review: synthetic utility of borocations as stoichiometric reagents and catalysts; 121refs.
A novel performance evaluation method of local detectors on non-planar scenes (2006)

This paper presents a new method for performance evaluation of local detectors on non-planar scenes. The framework extends the detector evaluation of Mikolajczyk and Schmid to non-planar scenes. The basic idea for establishing ground truth information on 3D scenes is the use of the trifocal tensor and the point transfer property. The repeatability and matching scores (using the SIFT descriptor) for the currently most popular local detectors are compared for increasing viewpoint change. In addition, detector combinations are evaluated by estimating the diversity of regions produced by the different detectors. The experiments reveal that the results differ from that of previous evaluations on planar scenes, especially that repeatability and matching scores will be much lower in real applications as suggested by previous evaluations.
Electronic structure and magnetism of Cr-doped ZnO nanowires (2011)

According to the spin-polarized density functional theory, we study the electronic structures, the magnetic and the optical properties of Cr-doped ZnO nanowires. The calculated results show ferromagnetic coupling for Cr atoms substitution for Zn atoms in ZnO nanowires along the [0001] direction, and the antiferromagnetic coupling with Cr-doped in ZnO nanowires along the [1010] and [0110] directions. The results reveal that the magnetic coupling state near the Fermi level gives rise to such a spin splitting phenomenon near the Fermi level, which indicates that Cr 3d and O 2p orbitals have intense hybrid effects. In addition, the spin electronic density results indicate that system magnetic moments are generated mainly by the unpaired 3d electrons of Cr atoms and are also related to the electron configuration. Moreover, the results of optical properties show that the obvious absorption peaks are observed in the far ultraviolet and the near ultraviolet regions and there is a red shift phenomenon in the ultraviolet region. These results indicate that the Cr-doped ZnO nanowires could be a promising dilute magnetic semiconductor material.
Detection of two distinct public specificities on HLA‐A28 bearing lymphocytes (1983)

We have used the antiglobulin augmented cytotoxicity assay and platelet absorption-elution techniques to investigate crossreactivity among certain antigens coded by the HLA-A locus. These serologic and absorption studies demonstrated two supertypic determinants, distinct from private determinants, associated with HLA-A locus gene products. One determinant was present on HLA-A2, Aw23, Aw24, and A28 bearing lymphocytes; the other was found on HLA-A28, Aw33, Aw34, and A26 bearing lymphocytes. The second determinant was not associated with HLA-A25. Both supertypic determinants are associated with HLA-A28.
Review of Cooling Technologies for Computer Products (2004)

This paper provides a broad review of the cooling technologies for computer products from desktop computers to large servers. For many years cooling technology has played a key role in enabling and facilitating the packaging and performance improvements in each new generation of computers. The role of internal and external thermal resistance in module level cooling is discussed in terms of heat removal from chips and module and examples are cited. The use of air-cooled heat sinks and liquid-cooled cold plates to improve module cooling is addressed. Immersion cooling as a scheme to accommodate high heat flux at the chip level is also discussed. Cooling at the system level is discussed in terms of air, hybrid, liquid, and refrigeration-cooled systems. The growing problem of data center thermal management is also considered. The paper concludes with a discussion of future challenges related to computer cooling technology.
Surface plasmon resonance‐based DNA microarrays: Comparison of thiol and phosphorothioate modified oligonucleotides (2013)

Abstract We present the use of thiol‐modified and phosphorothioate (PT)‐modified oligonucleotides for building DNA microarrays on the gold surface of surface plasmon resonance (SPR) chips. PT‐modified oligonucleotides (PTOs) have several advantages in comparison to thiol‐modified ones. They do not form disulfides and the PT groups can be introduced in any desired position of the molecular backbone of the oligonucleotide. Additionally, modifications with PT groups are not as cost‐intensive as thiol groups. The direct immobilization of the oligonucleotides via thiol and PT groups is compared. The affinity of the PT groups to gold is lower than that of thiol groups. Nevertheless, the hybridization kinetics of a model polymerase chain reaction (PCR) product could be studied in real time on a DNA microarray for both types of modified oligonucleotides. This contributes to clarification of previous, contradictory reports on the use of PTOs for their attachment to gold surfaces. The immobilization of PTOs could be improved by the introduction of iodoacetylated surfaces, which are reactive to bind PTs as well as thiols with high efficiency. Furthermore, the influence of the probe structure on the probe density and the hybridization was investigated.
Validation of Model of Cytochrome P450 2D6:  An in Silico Tool for Predicting Metabolism and Inhibition (2004)

There has been much interest in the development of a predictive model of cytochrome P450 2D6 particularly because this enzyme is involved in the oxidation of at least 50 drugs. Previously we have described the combined use of homology modeling and molecular docking to correctly position a range of substrates in the CYP2D6 active site with the known sites of metabolism above the heme. Here, our approach identifies correctly the site of metabolism of the atypical (no basic nitrogen) cytochrome P450 2D6 substrate, spirosulfonamide. The same method is used to screen a small compound database for cytochrome P450 2D6 inhibition. A database containing 33 compounds from the National Cancer Institute database was docked into our cytochrome P450 2D6 homology model using the program GOLDv2.0. Experimental IC50 values for the 33 compounds were determined; comparison with the corresponding docked scores revealed a correlation with a regression coefficient of r2 = 0.61 (q2 = 0.59). The method was able to discriminate between tight and weak binding compounds and correctly identified several novel inhibitors. The results therefore suggest that our approach, which combines homology modeling with molecular docking, has produced a useful predictive in silico tool for cytochrome P450 2D6 inhibition, which is best used as one filter in a multifilter database screen.
Real-Time Imaging of Pt 3 Fe Nanorod Growth in Solution (2012)

The growth of colloidal nanocrystal architectures by nanoparticle attachment is frequently reported as an alternative to the conventional growth by monomer attachment. However, the mechanism whereby nanoparticle attachment proceeds microscopically remains unclear. We report real-time transmission electron microscopy (TEM) imaging of the solution growth of Pt(3)Fe nanorods from nanoparticle building blocks. Observations revealed growth of winding polycrystalline nanoparticle chains by shape-directed nanoparticle attachment followed by straightening and orientation and shape corrections to yield single-crystal nanorods. Tracking nanoparticle growth trajectories allowed us to distinguish the force fields exerted by single nanoparticles and nanoparticle chains. Such quantification of nanoparticle interaction and understanding the growth pathways are important for the design of hierarchical nanomaterials and controlling nanocrystal self-assembly for functional devices.
<title>Automatic Visual Inspection Applied To Silicon Chip Packaging</title> (1983)

This paper discusses the architecture and algorithms of an image processing system designed to precisely locate and inspect silicon dice and thus guide a pick and place mechanism in an automatic chip packaging system. The CRS1000 image processing system uses a Motorola 68000 microprocessor in a flexible bus-oriented architecture which provides for the addition of high-speed hardware processors. Transformation of the image into an edge map allows the position and orientation of the die to be reliably and accurately measured.
Genome-Wide Analysis of the Heritability of Amyotrophic Lateral Sclerosis (2014)

We found the heritability of ALS to be significantly higher than previously reported. We also identified multiple, novel genomic regions that we hypothesize may contain causative risk variants that influence susceptibility to ALS.
SPUMIC: Simultaneous phase unwrapping and multipath interference cancellation in time-of-flight cameras using spectral methods (2013)

We propose a framework for simultaneous phase unwrapping and multipath interference cancellation (SPUMIC) in homodyne time-of-flight (ToF) cameras. Our multi-frequency acquisition framework is based on parametric modeling of the multipath interference phenomena. We use robust spectral estimation methods with low computational complexity to detect and estimate multipath parameters. Using simulations and analysis we demonstrate that our proposed solution is implementable in real-time on existing ToF cameras without requiring any hardware modifications.