gebhart/patrepeval huggingface dataset:
Early diagnosis of gestational diabetes mellitus using circulating microRNAs (2019)

Our findings suggest that circulating microRNAs are potential biomarkers for GDM in the first trimester. This warrants further examination and lays the foundation for producing a novel early non-invasive diagnostic tool for GDM.
Data from Sequential Prostate Magnetic Resonance Imaging in Newly Diagnosed High-risk Prostate Cancer Treated with Neoadjuvant Enzalutamide is Predictive of Therapeutic Response (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;For high-risk prostate cancer, standard treatment options include radical prostatectomy (RP) or radiotherapy plus androgen deprivation therapy (ADT). Despite definitive therapy, many patients will have disease recurrence. Imaging has the potential to better define characteristics of response and resistance. In this study, we evaluated prostate multiparametric MRI (mpMRI) before and after neoadjuvant enzalutamide plus ADT.&lt;/p&gt;Patients and Methods:&lt;p&gt;Men with localized intermediate- or high-risk prostate cancer underwent a baseline mpMRI and mpMRI-targeted biopsy followed by a second mpMRI after 6 months of enzalutamide and ADT prior to RP. Specimens were sectioned in the same plane as mpMRI using patient-specific 3D-printed molds to permit mpMRI-targeted biopsies to be compared with the same lesion from the RP. Specimens were analyzed for imaging and histologic correlates of response.&lt;/p&gt;Results:&lt;p&gt;Of 39 patients enrolled, 36 completed imaging and RP. Most patients (92%) had high-risk disease. Fifty-eight lesions were detected on baseline mpMRI, of which 40 (69%) remained measurable at 6-month follow-up imaging. Fifty-five of 59 lesions (93%) demonstrated &gt;50% volume reduction on posttreatment mpMRI. Three of 59 lesions (5%) demonstrated growth in size at follow-up imaging, with two lesions increasing more than 3-fold in volume. On whole-mount pathology, 15 patients demonstrated minimal residual disease (MRD) of &lt;0.05 cc or pathologic complete response. Low initial mpMRI relative tumor burden was most predictive of MRD on final pathology.&lt;/p&gt;Conclusions:&lt;p&gt;Low relative lesion volume at baseline mpMRI was predictive of pathologic response. A subset of patients had limited response. Selection of patients based on these metrics may improve outcomes in high-risk disease.&lt;/p&gt;&lt;/div&gt;
Estimating fetal dose from tube current‐modulated (TCM) and fixed tube current (FTC) abdominal/pelvis CT examinations (2019)

Good correlations were observed for nD<sub>fetus</sub> from TCM and FTC scans using either an exponential model with D<sub>w</sub> or a bivariate linear model with both D<sub>w</sub> and DE<sub>f</sub> . These results indicate that fetal dose from abdomen/pelvis CT examinations of pregnant patients of various gestational ages may be reasonably estimated with models that include (a) scanner-reported CTDI<sub>vol</sub> and (b) D<sub>w</sub> as a patient size metric, in addition to (c) DE<sub>f</sub> if available. These results also suggest that SSDE f-factors may provide a reasonable (within ±25%) estimate of nD<sub>fetus</sub> for TCM and FTC abdomen/pelvis CT exams.
Multiplexed Identification of Blood-Borne Bacterial Pathogens by Use of a Novel 16S rRNA Gene PCR-Ligase Detection Reaction-Capillary Electrophoresis Assay (2007)

We have developed a novel high-throughput PCR-ligase detection reaction-capillary electrophoresis (PCR-LDR-CE) assay for the multiplexed identification of 20 blood-borne pathogens (Staphylococcus epidermidis, Staphylococcus aureus, Bacillus cereus, Enterococcus faecalis, Enterococcus faecium, Listeria monocytogenes, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa, Acinetobacter baumannii, Neisseria meningitidis, Bacteroides fragilis, Bacillus anthracis, Yersinia pestis, Francisella tularensis, and Brucella abortus), the last four of which are biothreat agents. The method relies on the amplification of two regions within the bacterial 16S rRNA gene, using universal PCR primers and querying the identity of specific single-nucleotide polymorphisms within the amplified regions in a subsequent LDR. The ligation products vary in color and size and are separated by CE. Each organism generates a specific pattern of ligation products, which can be used to distinguish the pathogens using an automated software program we developed for that purpose. The assay has been verified on 315 clinical isolates and demonstrated a detection sensitivity of 98%. Additionally, 484 seeded blood cultures were tested, with a detection sensitivity of 97.7%. The ability to identify geographically variant strains of the organisms was determined by testing 132 isolates obtained from across the United States. In summary, the PCR-LDR-CE assay can successfully identify, in a multiplexed fashion, a panel of 20 blood-borne pathogens with high sensitivity and specificity.
iPSCs: A Preclinical Drug Research Tool for Neurological Disorders (2021)

The development and commercialization of new drugs is an articulated, lengthy, and very expensive process that proceeds through several steps, starting from target identification, screening new leading compounds for testing in preclinical studies, and subsequently in clinical trials to reach the final approval for therapeutic use. Preclinical studies are usually performed using both cell cultures and animal models, although they do not completely resume the complexity of human diseases, in particular neurodegenerative conditions. To this regard, stem cells represent a powerful tool in all steps of drug discovery. The recent advancement in induced Pluripotent Stem Cells (iPSCs) technology has opened the possibility to obtain patient-specific disease models for drug screening and development. Here, we report the use of iPSCs as a disease model for drug development in the contest of neurological disorders, including Alzheimer's (AD) and Parkinson's disease (PD), Amyotrophic lateral Sclerosis (ALS), and Fragile X syndrome (FRAX).
Influencia do Al na tecnologia do quartzo sintetico (1990)

Orientador: Carlos Kenichi Suzuki
Attraction behaviour of three entomopathogenic nematode species towards infected and uninfected hosts (2006)

Entomopathogenic nematode infective juveniles are likely to encounter both uninfected and infected insects and host quality depends on the stage of the infection. We hypothesized that nematode response to infected hosts will change over the course of an infection. Here, we tested this hypothesis by focusing on the influence of host infection status on long-range attraction to host volatile cues. The attraction response of 3 nematode species (Steinernema carpocapsae, S. glaseri and S. riobrave) with different foraging strategies to infected and uninfected insects (Galleria mellonella and Tenebrio molitor) was tested at 24 h intervals from start of infection to emergence of infective juveniles from depleted host. As expected, based on their foraging strategies, S. carpocapsae was not very responsive to hosts, S. glaseri was highly responsive and S. riobrave was intermediate. Generally, the level of attraction did not change with time after infection and was similar between infected and uninfected hosts. An exception was S. glaseri infected T. molitor, which tended to be less attractive to S. glaseri than uninfected hosts. These results suggest that any influence of host infection status on infection behaviour is occurring at subsequent steps in the host-infection process than host attraction, or involves non-volatile cues.
Autometallographic demonstration of zinc ions in rat sperm cells (1997)

An in-vitro technique for autometallographic (AMG) demonstration of chelatable zinc in electroejaculated sperm cells and spermatozoa from the epididymis is presented and the localization of zinc ions in rat spermatozoa is described. Sperm cells from caput epididymis showed zinc staining in all parts of the tail and a sparse, dispersed staining in the acrosome. Spermatozoa from cauda epididymis showed heavy staining in the acrosome but no staining in the tail, or post-acrosomal part of the sperm head. This distinct acrosomal AMG staining was also found in ejaculated spermatozoa, but additionally a segmentation of the tail was seen based on differences in staining intensity. The membrane penetrating chelator diethyldithiocarbamate (DEDTC) was found to block the AMG staining whereas calcium-EDTA, known not to pass through cell membranes, did not influence the staining, proving that the detected zinc ions are intracellularly located. Two different approaches for demonstrating the presence of a chelatable zinc pool at electron microscope levels are presented, and the ultrastructural presence of AMG grains located in the acrosome and in the mitochondria of the midpiece is demonstrated. It is postulated that an exchange of zinc ions takes place between the epididymal epithelium and the sperm cells as they pass along the epididymal duct.
Development of a tomographic myelin scan (1981)

The principle that myelin can be imaged noninvasively using the emission tomographic distribution of a lipophilic radioactive tracer was investigated. Properties of agents suitable for noninvasive myelin scanning are discussed with specific reference to blood-brain barrier permeability, metabolism, and tracer lipophilicity. The brain distributions of inert tracers are correlated with their partitioning between octanol and saline. A test probe, iodobenzene, was labeled with iodine 125 for preliminary invasive studies in the rabbit. The equilibrium brain distribution, determined either autoradiographically or by regional dissection, corresponded closely to that of myelin. 123I-labeled iodobenzene, a gamma-emitting analog, was then administered to a monkey, and tomographic reconstruction revealed a pattern of brain uptake corresponding to white matter.
Strategies for protection and control standardization and integrated data management applications (2008)

Breakthroughs in power system protection and control technology support significant industry facelifts. Streamlined selection and application of products and systems have become possible and tools for design and implementation have become easier to work with. Nonetheless, the planning, engineering, procurement and implementation of protection, control, data management and automation at a major power utility is a complex endeavor, from both the technical and the business process perspectives. This paper will explore the experiences of a major power company in managing through a true paradigm shift, and further narrow the focus to the impact of these changes on substation networks, data management, technology risk management, and cyber security. The key elements of success include a clear vision, in-depth understanding of past practices, a detailed roadmap, support and encouragement from internal leadership, and partnership with key manufacturers willing to support the process with R&D investments that benefit not only the power utility but also the industry.
Data for: Compact, Flexible Conducting Polymer/Graphene Nanocomposites for High Volumetric Supercapacitors (2018)

RESEARCH DATA
Fireflies (2006)

This paper describes and evaluates Fireflies , a scalable protocol for supporting intrusion-tolerant network overlays. While such a protocol cannot distinguish Byzantine nodes from correct nodes in general, Fireflies provides correct nodes with a reasonably current view of which nodes are live, as well as a pseudo-random mesh for communication. The amount of data sent by correct nodes grows linearly with the aggregate rate of failures and recoveries, even if provoked by Byzantine nodes. The set of correct nodes form a connected submesh; correct nodes cannot be eclipsed by Byzantine nodes. Fireflies is deployed and evaluated on PlanetLab.
Control of Particle Size by Coagulation of Novel Condensation Aerosols in Reservoir Chambers (2002)

The coagulation growth behavior of capillary aerosol generator (CAG) condensation aerosols was investigated in a series of reservoir chambers. Aerosols consisted of a condensed system of 0.7% w/w benzil (model drug) in propylene glycol (vehicle). These were generated into 250-, 500-, 1,000-, and 2,000-mL reservoirs in both flowing air-stream and static air experiments. Changes in drug and total aerosol particle size were measured by a MOUDI cascade impactor. In both series of experiments the CAG aerosols grew in size. Growth in flowing air-stream experiments was attributed to the amount of accumulation aerosols experienced in reservoirs during sampling and increased with increasing reservoir volume. Mean (SD) MMAD's for the total mass distribution measured for the 250- and 2,000-mL reservoirs were 0.70 (0.02) and 0.87 (0.03) microm, respectively. For the benzil mass distribution, they were 0.64 (0.02) and 0.87 (0.06) microm, respectively. Growth in static air experiments was dependent on the volume aerosol boluses were restricted to and increased with decreasing reservoir volume. Mean (SD) initial MMAD's for the benzil mass distribution for the 250- and 2,000-mL reservoirs were 1.44 (0.03) and 1.24 (0.08) microm, respectively. Holding aerosols for up to 60 sec further increased their size. Mean (SD) MMAD's for benzil after holding for 60 sec in these reservoirs were 2.28 (0.04) and 1.67 (0.09) microm, respectively. The coagulation behavior and therefore particle size of CAG aerosols may be modified and controlled by reservoir chambers for drug targeting within the respiratory tract.
A NOVEL ASSAY FOR DETECTION OF COMPLEMENT-FIXING ANTIBODIES SPECIFIC FOR DONOR LYMPHOCYTES AND ENDOTHELIAL PRECURSOR CELLS USING THE XM-ONE® CROSSMATCH TEST (2010)

Holgersson, J.1; Al-mahri, A. K.S.2; Johansson, S. M.2; Mustonen, P.2; Alheim, M.2 Author Information
An integrated optical CO2 sensor. Phase 0: Design and fabrication of critical elements (1994)

Significant progress has been made toward all of the goals for the first phase of the project short of actual fabrication of a light path. Two alternative approaches to fabricating gold mirrors using the basic LIGA process were developed, one using electroplated solid gold mirrors and the second using gold plated over a nickel base. A new method of fabrication, the transfer mask process, was developed and demonstrated. Analysis of the projected surface roughness and beam divergence effects was completed. With gold surface with low surface roughness scattering losses are expected to be insignificant. Beam divergence due to diffraction will require a modification of the original design, but should be eliminated by fabricating mirrors 1000 mu m in height by 1000 mu m in width and using a source with an initial beam radius greater than 300 mu m. This may eliminate any need for focusing optics. Since the modified design does not affect the mask layout, ordering of the mask and fabrication of the test structures can begin immediately at the start of Phase 1.
Integration of nanoscale zero-valent iron and functional anaerobic bacteria for groundwater remediation: A review (2019)

The technology of integrating nanoscale zero-valent iron (nZVI) and functional anaerobic bacteria has broad prospects for groundwater remediation. This review focuses on the interactions between nZVI and three kinds of functional anaerobic bacteria: organohalide-respiring bacteria (OHRB), sulfate reducing bacteria (SRB) and iron reducing bacteria (IRB), which are commonly used in the anaerobic bioremediation. The coupling effects of nZVI and the functional bacteria on the contaminant removal in the integrated system are summarized. Generally, nZVI could create a suitable living condition for the growth and activity of anaerobic bacteria. OHRB and SRB could synergistically degrade organic halides and remove heavy metals with nZVI, and IRB could reactive the passivated nZVI by reducing the iron (hydr)oxides on the surface of nZVI. Moreover, the roles of these anaerobic bacteria in contaminant removal coupling with nZVI and the degradation mechanisms are illustrated. In addition, this review also discusses the main factors influencing the removal efficiency of contaminants in the integrated treatment system, including nZVI species and dosage, inorganic ions, organic matters, pH, type of pollutants, temperature, and carbon/energy sources, etc. Among these factors, the nZVI species and dosage play a fundamental role due to the potential cytotoxicity of nZVI, which might exert a negative impact on the performance of this integrated system. Lastly, the future research needs are proposed to better understand this integrated technology and effectively apply it in groundwater remediation.
Epithelioid haemangioendothelioma of the breast (1999)

This article describes histopathological, immunohistologic, and morphometric features of an epithelioid haemangioendothelioma that presented in the breast of a 30-year-old woman. Histologically the tumour was composed of large round, polygonal, slightly spindle shaped endothelial cells lying in a myxoid matrix. The lesion exhibited primitive vasoformation characterized by the presence of cytoplasmic vacuoles. The tumour cells reacted positively to F-VIII related antigen, whereas mammary ducts entrapped by the tumour cells reacted positively with keratin. Although the breast is an unusual location for this type of lesion, epithelioid haemangioendothelioma should be considered a rare differential diagnosis of a breast mass.
Antigenicity of Hereditary Human Gamma Globulin (Gm) Factors--Biological and Biochemical Aspects (1964)

Hereditary gamma globulins (Gm's) of different genetic types are detected by inhibition or non-inhibition of specific agglutination systems (e.g. Grubb and Laurell, 1956; Ropartz, Lenoir, and Rivat, 1961). Although inhibition of agglutination is similarly utilized in tests of specificity of many antigen-antibody systems, early workers considered the Gm-anti Gm reactions as nonimmunologic, and the anti-Gm agglutinators as nonspecific “reagins,” analogous to the Wasserman “reagins” (Grubb, 1958, 1961; Harboe, 1959). The evidence cited against the antigen nature of these Gm factors and the antibody character of the homologous anti-γ-globulin, included (1) lack of biologic reaction on infusion of γ-globulin into subjects possessing anti-γ-globulin agglutinators (Grubb, 1961), and on infusion of anti-γ-globulins into normal subjects (Harris and Vaughn, 1961); (2) similar survival time of injected Gm(a+) γ-globulin in patients with anti-Gm(a) as compared with normal subjects (Strassle, Alpstag, and Miescher, 1958); and (3) the presence of agglutinators only in patients with rheumatoid...
The Relation between Monetary Policy and Financial-Stability Policy (2019)

What is the relation between monetary policy and financialstability policy? How can they be distinguished? How similar or different are they? Should they have the same or different goals? How should they be conducted? Should they be coordinated or conducted separately? Should they be conducted by the same or different authorities? What if monetary policy would pose a threat to financial stability? Should monetary policy ever 'lean against the wind' (of asset prices and credit booms)?
Delayed-type hypersensitivity responses to a cell wall fraction of the mycelial phase of Coccidioides immitis (1975)

A skin test-active fraction was isolated from the mycelial-phase cell walls of Coccidioides immitis. This alkali-soluble, water-soluble antigen (C-ASWS) elicited positive reactions in 22 of 24 (92%) of the Coccidioides-sensitized guinea pigs whereas only 14 (54%) of the same guinea pigs reacted to commercial coccidioidin (BioCox). None of the 21 Histoplasma-sensitized guinea pigs cross-reacted with the C-ASWS antigen. Footpad tests in mice actively infected with Coccidioides further established the efficacy of the C-ASWS antigen in eliciting a delayed-type hypersensitivity response. One-microgram doses of C-ASWS produced reactions comparable to 100-mug doses of nondialyzable coccidioidin (Smith's lot 64 D4). The C-ASWS fractions isolated from three different C. immitis strains showed similar reactivity in terms of the number of positive reactions produced in Coccidioides-sensitized guinea pigs. However, the induration responses (diameter in millimeters) elicited by the C-ASWS fraction of one strain were significantly less than those elicited by the C-ASWS fractions of the other two C. immitis strains.
On Margin-Based Cluster Recovery with Oracle Queries (2021)

We study an active cluster recovery problem where, given a set of $n$ points and an oracle answering queries like "are these two points in the same cluster?", the task is to recover exactly all clusters using as few queries as possible. We begin by introducing a simple but general notion of margin between clusters that captures, as special cases, the margins used in previous work, the classic SVM margin, and standard notions of stability for center-based clusterings. Then, under our margin assumptions we design algorithms that, in a variety of settings, recover all clusters exactly using only $O(\log n)$ queries. For the Euclidean case, $\mathbb{R}^m$, we give an algorithm that recovers arbitrary convex clusters, in polynomial time, and with a number of queries that is lower than the best existing algorithm by $Θ(m^m)$ factors. For general pseudometric spaces, where clusters might not be convex or might not have any notion of shape, we give an algorithm that achieves the $O(\log n)$ query bound, and is provably near-optimal as a function of the packing number of the space. Finally, for clusterings realized by binary concept classes, we give a combinatorial characterization of recoverability with $O(\log n)$ queries, and we show that, for many concept classes in Euclidean spaces, this characterization is equivalent to our margin condition. Our results show a deep connection between cluster margins and active cluster recoverability.
Congestion-aware logic synthesis (2003)

In this era of Deep Sub-Micron (DSM) technologies, the impact of interconnects is becoming increasingly important as it relates to integrated circuit (IC) functionality and performance. In the traditional top-down IC design flow, interconnect effects are first taken into account during logic synthesis by way of wireload models. However, for technologies of 0.25 /spl mu/m and below, the wiring capacitance dominates the gate capacitance and the delay estimation based on fanout and design legacy statistics can be highly inaccurate. In addition, logic block size is no longer dictated solely by total cell area, and is often limited by wiring area resources. For these reasons, wiring congestion is an extremely important design factor, and should be taken into consideration at the earliest possible stages of the design flow. In this paper we propose a novel methodology to incorporate congestion minimization within logic synthesis, and present results for industrial circuits that validate our approach.