gebhart/patrepeval huggingface dataset:
Principles of Biomolecular Network Design (2013)

Networks of biomolecular unit cells are proposed as a new type of biologically inspired intelligent materials. These materials are derived from natural cellular mechanics and aim to improve current biologically-inspired technologies by recreating the desired systems from the basic building block of the natural world; the cell. The individual biomolecular unit cell is able to replicate natural cellular abilities through a combination of lipid bilayer membranes containing embedded proteins and peptides. While individual unit cells offer an ideal testing environment for demonstrating proofs of concept, more advanced abilities require larger networks, utilizing cell-to-cell interactions. The cell-to-cell interactions often involve multiple modes of communication, which have been identified for this paper as primarily electrical, chemical, and mechanical phenomenon. Previous modeling efforts have incorporated the electrical portion through equivalent circuit models, but these lack the ability to fully explain some of the network characteristics. A new formulation is presented here to illustrate how these three classes of phenomenon may be coupled to achieve various engineering design goals.
A Single-Stage Switched-Boost Grid-Connected Five-Level Converter With Integrated Active Power Decoupling Under Polluted Grid Voltage Condition (2023)

Grid-connected inverters with a multilevel output voltage and an integrated dynamic voltage boosting feature are promising to achieve higher overall efficiency/power density, reduced output filter size, and better power quality. However, the input current of such a single-stage system might be pulsating with low- and high-frequency ripple contents in a single-phase grid-connected application. To tackle this challenge, active power decoupling (APD) can be used to keep the input current flat and reduce the current stress of the devices with an efficient performance. On the other hand, the grid voltage is usually non-ideal in practice, polluted with the harmonics. This causes additional complexity in the closed-loop control system to maintain the injected power quality. The aim of this article is to apply a tailored closed-loop APD control on a recently proposed single-source single-stage switched-boost (SB) five-level converter leading to further enhancing its overall efficiency without adding any extra circuit components. A distinctive feature of the proposed solution is using a single proportional-resonant controller with a filtered feed-forward term to achieve APD, even under a distorted grid voltage condition. This solution can also be applied on other single-stage SB-based converters as long as their input current before integration of the APD control contains a low-frequency ripple content. A 2 kW SiC-based prototype is built to validate the feasibility and accurate performance of the proposed method via experiments when connected to a grid with harmonic pollution.
Remapping the quantum frontier (2008)

In 1994 the mathematician Peter Shor, then working at AT&T Bell Laboratories in the US, applied quantum mechanics to an age-old problem in number theory and made a remarkable discovery. He showed that a computer that operates on and processes quantum systems could factor large integers exponentially faster than a conventional computer. This result attracted a lot of attention because the difficulty of factoring large numbers is what ensures the security of modern cryptography schemes – even the best conventional computer would take several thousand years to factor a number with more than about 150 digits. Shor's quantum factoring algorithm could, in principle, break such encryption standards – a possibility that led to an explosion of interest in quantum information science. Until then it was a field that had largely been a mere curiosity, despite notable contributions from the likes of Richard Feynman and David Deutsch.
Molecular valence calculations on cyclohexasulfur, cycloheptasulfur, and cyclooctasulfur (1987)

Abstract A theoretical study of homocyclic sulfur species S 6 , S 7 , and S 8 was carried out using a molecular valence method involving stepwise approximations for orthogonality and core‐valence interactions. The valence shell orbitals are described at the minimal basis level. The geometries of the molecules are predicted well as compared with other theoretical studies and the experimental values. The slight overestimation of the SS bond length is typical to the nonpolarized basis sets. The energies of the valence orbitals are well in accord with the conventional all‐electron ab initio results. The trend in the stabilities of the three molecules is discussed. The present method provides an attractive possibility to study homocyclic and heterocyclic systems involving heavier chalcogens with no increase of the computing time.
Deterministic learning automata solutions to the equipartitioning problem (1988)

Three deterministic learning automata solutions to the problem of equipartitioning are presented. Although the first two are epsilon -optimal, they seem to be practically feasible only when a set of W objects is small. The last solution, which uses a novel learning automaton, demonstrates an excellent partitioning capability. Experimentally, this solution converges an order of magnitude faster than the best known algorithm in the literature.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
New Sesquiterpenoids from Cabreuva Oil (1986)

Abstract Six sesquiterpenoids 1 – 6 , formally derived from (+)‐( S )‐nerolidol by oxidative cyclization, have been isolated for the first time from commercial cabreuva oil. Whereas the two tetrahydrofurans 5 and 6 have already been described, the four bicyclic ethers (cabreuva oxides A–D) 1 – 4 are new. The structures of 1 – 4 are confirmed by synthesis and their absolute configurations are shown to be 3 S . The organoleptic properties of the synthetic cabreuva oxides are discussed.
ChemInform Abstract: DERIVATE SUBSTITUIERTER VINYLPHOSPHONSAEUREN 10. MITT. DERIVATE VON ALPHA‐ALKYL‐BETA‐ALKOXYVINYLPHOSPHON‐ UND ‐THIOPHOSPHONSAEUREN (1971)

Abstract Die Phosphonsäuredichloride (I) bilden mit den Alkoholen (II) in Gegenwart von Triäthylamin oder besser in der Gegenwart der entsprechenden Natriumalkoholate die Dialkylphosphon‐ und ‐thiophosphonsäureester (III).
Reducing the Influence of Soil Moisture on the Estimation of Clay from Hyperspectral Data: A Case Study Using Simulated PRISMA Data (2015)

Soil moisture hampers the estimation of soil variables such as clay content from remote and proximal sensing data, reducing the strength of the relevant spectral absorption features. In the present study, two different strategies have been evaluated for their ability to minimize the influence of soil moisture on clay estimation by using soil spectra acquired in a laboratory and by simulating satellite hyperspectral data. Simulated satellite data were obtained according to the spectral characteristics of the forthcoming hyperspectral imager on board of the Italian PRISMA satellite mission. The soil datasets were split into four groups according to the water content. For each soil moisture level a prediction model was applied, using either spectral indices or partial least squares regression (PLSR). Prediction models were either specifically developed for the soil moisture level or calibrated using synthetically dry soil spectra, generated from wet soil data. Synthetically dry spectra were obtained using a new technique based on the effects caused by soil moisture on the optical spectrum from 400 to 2400 nm. The estimation of soil clay content, when using different prediction models according to soil moisture, was slightly more accurate as compared to the use of synthetically dry soil spectra, both employing clay indices and PLSR models. The results obtained in this study demonstrate that the a priori knowledge of the soil moisture class can reduce the error of clay estimation when using hyperspectral remote sensing data, such as those that will be provided by the PRISMA satellite mission in the near future.
Phosphorylierung reguliert den Membrantransport von Peptiden (2017)

Abstract Die Phosphorylierung und Dephosphorylierung von Peptiden durch Kinasen und Phosphatasen ist ein allgegenwärtiger Mechanismus der Signaltransduktion in biologischen Systemen. Eine unnatürlich hohe oder niedrige Aktivität dieser Enzyme steht im Zusammenhang mit vielen Krankheiten. Hier führen wir amphiphile Calixarene als supramolekulare Schlüsselkomponenten für einen Membrantransport von Peptiden ein, der sich durch Phosphorylierung regulieren lässt. Mithilfe von farbstoffbeladenen Liposomen zeigen wir, dass diese Calixarene als Gegenionen für etablierte zellpenetrierende Peptide fungieren und deren Transport effizient aktivieren können. Die ermittelten EC 50 ‐Werte liegen im niedrigen nanomolaren Bereich. Die Calixarene aktivieren sogar den Membrantransport von kurzen Peptiden, die Substrate für Kinasen in Signaltransduktionskaskaden sind. Dadurch dass das phosphorylierte Produkt viel weniger effektiv transportiert wird, ermöglicht dies die Regulierung des Membrantransports durch Proteinkinase A (PKA) und Proteinkinase C (PKC). Daraus folgt auch eine markierungsfreie Methode, um die Aktivität dieser Enzyme mittels Fluoreszenz nachzuweisen.
Assessment of alpha1-antitrypsin and alpha2-macroglobulin levels in obese patients. (2008)

Metabolic disturbances in obesity are associated with an elevated level of alpha1ATp, which might confirm its important role in the development of vascular incidents in obese patients. An increased risk of vascular pathological lesions in obesity is probably not associated with alpha2MG levels.
The Origins of Life: A Status Report (1998)

Research Article| January 01 1998 The Origins of Life: A Status Report Gerald F. Joyce, Gerald F. Joyce Search for other works by this author on: This Site PubMed Google Scholar Leslie E. Orgel Leslie E. Orgel Search for other works by this author on: This Site PubMed Google Scholar The American Biology Teacher (1998) 60 (1): 10–12. https://doi.org/10.2307/4450404 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Gerald F. Joyce, Leslie E. Orgel; The Origins of Life: A Status Report. The American Biology Teacher 1 January 1998; 60 (1): 10–12. doi: https://doi.org/10.2307/4450404 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe American Biology Teacher Search This content is only available via PDF. Copyright 1998 The National Association of Biology Teachers Article PDF first page preview Close Modal You do not currently have access to this content.
Superconducting VAR control (2023)

Static VAR control means employing an asymmetrically controlled Graetz bridge and a superconducting direct current coil having low losses and low cost characteristics.
Immunosuppressive effects of 1,2 5-dihydroxyvitamin D3 and its analogue calcipotriol on epidermal cells (1994)

1,25‐Dihydroxyvitamin D3 (1,25(OH)2D3: calcitriol) is the biologically active form of vitamin D. This hormone is a potent immunoregulatory agent. Calcipotriol is a synthetic analogue of 1,25(OH)2D3, with similar receptor binding, and comparable effects on cell proliferation and differentiation, but less potent effects on calcium metabolism. As a step towards understanding the mechanisms by which vitamin D compounds affect T‐cell activation by epidermal cells (EC), we assessed the effects of 1,25(OH)2D3 and calcipotriol on the human allogeneic mixed epidermal cell‐lymphocyte reaction. All experiments were performed both with 1,25(OH)2D3, and calcipotriol, with similar results. Both compounds had potent immunoinhibitory properties on this model, and enhanced the immunosuppressive effects of cyclosporin A. Using preincubation experiments, we found that pretreatment of EC with 1,25(OH)2D3 resulted in a more pronounced inhibition than preincubation of lymphoid cells. The epidermal targets of this inhibitory effect have been further investigated, using cultures with freshly isolated Langerhans cells (LC) or LC‐depleted keratinocytes, separated by an immunomagnetic particle technique. Pretreatment of LC induced a 30% decrease of proliferation, compared with vehicle‐treated LC. These calcitriol‐pulsed LC did not decrease the proliferation induced by unmodified autologous EC. As expected. LC‐depleted keratinocytes failed to stimulate allogeneic lymphocytes. When added to autologous unmodified EC, however, calcitriol‐pulsed keratinocytes induced an 85% decrease of proliferation, compared with vehicle‐treated keratinocytes. The phenotypic expression of HLA‐DR, ‐DQ, and ‐DP antigens on EC, assessed by immunoalkaline phosphatase staining, was not modified after a 2‐h or 24‐h pulse with 1,25(OH)2D3 or calcipotriol. The inhibitory effect of vitamin D compounds on EC was not modified by indomethacin, but was partially reversed by the addition of anti‐TGF‐β neutralizing antibodies. In conclusion, 1,25(OH)2D3 and calcipotriol may limit the immune response in human skin through decreased antigen presentation, mediated both by a direct effect on LC and indirectly through modulation of the production of cytokines by keratinocytes.
Metal Sulfides (2010)

Abstract Transition metal sulfide catalysts are widely used in hydrotreatment applications particularly for removing heteroelements (S, N, O) from petroleum feedstock. The present chapter will provide description of the different catalytically active sulfides, particularly for the MoS 2 ‐based catalysts promoted by Co or Ni. The different hypotheses at the origin of promotion will be first presented followed by the general procedures available for the synthesis of metal sulfides. Emphasis will also be applied to the real nature of the active phase under hydrotreating steady‐state conditions. Finally, the most recent studies based on surface science or theoretical studies will be presented.
Gold-catalysed synthesis of phosphonate-substituted oxetan-3-ones – an easy access to highly strained HWE reagents (2021)

Gold-catalysed reaction of alkynyl phosphonates to attain alkenyl substituted oxetan-3-ones via subsequent HWE reaction.
The Diverse Roles of TAO Kinases in Health and Diseases (2020)

Thousand and one kinases (TAOKs) are members of the MAP kinase kinase kinase (MAP3K) family. Three members of this subfamily, TAOK1, 2, and 3, have been identified in mammals. It has been shown that TAOK1, 2 and 3 regulate the p38 MAPK and Hippo signaling pathways, while TAOK 1 and 2 modulate the SAPK/JNK cascade. Furthermore, TAOKs are involved in additional interactions with other cellular proteins and all of these pathways modulate vital physiological and pathophysiological responses in cells and tissues. Dysregulation of TAOK-related pathways is implicated in the development of diseases including inflammatory and immune disorders, cancer and drug resistance, and autism and Alzheimer's diseases. This review collates current knowledge concerning the roles of TAOKs in protein-protein interaction, signal transduction, physiological regulation, and pathogenesis and summarizes the recent development of TAOK-specific inhibitors that have the potential to ameliorate TAOKs' effects in pathological situations.
On the generation of shock waves in an inverse pinch (1966)

A problem inherent in magnetic shock tubes is the difficulty of achieving separation of the driving current sheet and the shock wave. If such devices are to be applied to produce shock waves for experimentation, then separation will usually be a necessary requirement. In the present experiments in an inverse pinch shock tube, preliminary measurements showed that not only was separation not achieved, but under certain conditions the shock was actually found to be located far behind the front of the current sheet. This appeared to be a paradoxical case of the shock wave pushing the piston. Moreover, measurements of the current sheet velocity indicated that the interaction of the current sheet with the gas should be strong enough to sweep up all the gas encountered by the current sheet and thus to produce a shock wave moving ahead of it. In order to find explanations for the absence of separation and for some other puzzling aspects of these early experiments, further measurements were made to study in more detail the processes taking place in the device. These included measurements of the radial electric field with electrostatic probes and of the ionization levels by the technique of spectral line broadening. The results of these measurements show that the degree of ionization is surprisingly low and that the amount of gas leaking through the current sheet is significantly high in some cases. The conclusion is then reached that although the so-called snowplow model is successful in predicting the current sheet velocity, it does not lead to the correct picture of the physical processes taking place. Finally, conditions for which separation may be achievable are inferred from the experiments.
A personal computer prototype to support ISDN service negotiations (2003)

Experience with a prototype service negotiation system for the integrated services digital network (ISDN) is presented. A commercially available database management system and high-level application language (dBASE III PLUS Version 1.1) were used as the platform on which to build the system. The user-system dialogue chosen for the prototype is a combination of menus and fill-in forms. The prototype was installed at Illinois Bell Telephone Company's Oak Brook facility and was used during negotiations for that company's ISDN trial. Additional prototyping efforts that built on these experiences are also reported. The prototyping activities demonstrate the feasibility of using PC-based prototypes, developed quickly using high-level languages with commercial tools, to identify issues specific to operations systems support for ISDN negotiations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Poster Presentations (2012)

Previous works have shown that genome reacts to heavy-metal stress by selective amplification of (G+C)-rich highly repetitive/ non coding DNA. Such phenomenon takes place similarly both in protonemal and in leafy shoot phases. However, when metals are removed from culture medium, if stress has taken place during the leafy shoot phase new-formed DNA is eliminated from nucleus; and vice versa, if stress has taken place during protonemal phase, the new-formed DNA remains inside genome of the target organism.Our idea is that such different behaviour of metal-induced repetitive/non coding DNA could be linked to different role of these two phases: in fact, while in protonemal phase protective role of repetitive/non-coding DNA may have a particular importance, conversely, in leafy shoot phase preservation of new generation from genome’s changes may have the priority. Based on these considerations, we have analyzed the behavior of metal-induced repetitive DNA during transition from protonemal to leafy shoot phase in different kind of situations. Our results have showed that: (i) most of repetitive/non coding DNA sequences triggered by heavy-metal stress in protonemal phase, even if apparently it should be stabilized in the genome, it is not actually transmitted to leafy shoots phase; (ii) in the leafy shoots resulting from stressed protonemata, answer of repetitive DNA to metal stress is similar but much less meaningful compared to the one trigged by the same conditions in the leafy shoots resulting from unstressed protonemata; (iii) in the leafy shoots resulting directly from those from mine through vegetative way, heavy-metal stress doesn’t trigger any type of DNA amplification. Some hypotheses are discussed on the basis of observed morphological and functional modifications.
Pilots for joint channel estimation in multi-user OFDM mobile radio systems (2003)

This paper addresses the issue of pilot design for the purpose of channel estimation in the uplink of a mobile radio system applying OFDM. The pilots are designed based on the performance criteria SNR degradation for noise scenarios and variation coefficient for interference scenarios. Besides the method of randomly generating pilots and the design method based on the disjoint subcarrier approach, a novel method for designing pilots based on Walsh codes is presented in the paper. The pilots resulting from the aforementioned method exhibit a very good performance both in noise and in interference scenarios.
Estudo in vitro da resistência ao cisalhamento de sistema adesivo após o uso do laser de Er:Yag na dentina bovina (2010)

O emprego do laser de Er:Yag no preparo e condicionamento dental tem sido sugerido, entretanto, o efeito dasua utilização na odontologia restauradora apresenta alguns questionamentos, como os que se refere aos parâmetrosmais adequados para a energia a ser entregue ao substrato dental. Diante destes fatos propusemo- nos arealizar essa pesquisa com o objetivo de selecionar qual o parâmetro mais efetivo, quando se considera a potênciade 60 mJ ou 100 mJ, na resistência ao cisalhamento de sistemas adesivos associados a resina composta.Sessenta incisivos bovinos recém-extraídos foram desgastados para exposição da dentina vestibular e realizaçãodos procedimentos restauradores. As amostras foram divididas em seis grupos com dez dentes em cada grupo:G1: adesivo autocondicionante Clearfill SE Bond (Kuraray); G2: laser com 60 mJ de potência,10Hz, sistemaadesivo autocondicionante Clearfill SE Bond (Kuraray); G3: laser com 100mJ de potência e 10Hz, sistema adesivoClearfil SE Bond (Kuraray); G4: condicionamento utilizando-se ácido fosfórico à 37% mais adesivo monocomponenteSingle Bond; G5: laser com 60 mJ de potência,10Hz, condicionamento com ácido fosfórico à 37%e sistema adesivo Single Bond (3M); G6: laser com 100mJ de potência,10Hz, condicionamento com ácido fosfóricoà 37% e sistema adesivo Single Bond. Sobre a superfície de dentina foram confeccionados cilindros deresina, após 24 horas realizou-se o ensaio de resistência ao cisalhamento. Os resultados foram submetidos àanálise de variância e ao teste Tukey. Concluímos que os adesivos avaliados não apresentaram diferença estatísticaquanto a resistência ao cisalhamento e que o laser promoveu diminuição estatisticamente significante naresistência de união da resina composta à dentina.
Alterations of p16INK4A and p15INK4B genes in gastric carcinomas (1997)

Deletions or mutations of the p16 and p15 genes are uncommon in primary gastric carcinomas. However, defective mRNA transcription, sometimes by aberrant DNA methylation, might be one of the pathways of inactivation of the p16 gene that leads to the development of gastric carcinoma.
Chest Pain Centers (2015)

Enhanced collaboration among international bodies interested in promoting high quality care might extend the opportunity for accreditation of facilities that treat cardiovascular patients, with national programs designed to meet local needs and local healthcare system requirements.