gebhart/patrepeval huggingface dataset:
SVDFeature: a toolkit for feature-based collaborative filtering (2012)

Classical Burkitt lymphoma/leukemia (BL/L) presenting L3 morphology is found in 1% of childhood ALL. Recently, it has been described that secondary abnormalities could influence the prognosis of these patients. However, little information is available on these cytogenetic abnormalities and their prognostic importance in BL/L. Here, we report four new childhood BL/L cases associated with duplication within 1q or 13q, which exhibited a very unfavorable therapeutic response. We performed both classical and molecular cytogenetic analysis by multicolor chromosome banding of the secondary abnormalities involving the long arms of chromosome 1 or 13. These patients were previously treated with BFM-90 protocol. All of them died during or after the initial treatment. Here, for the first time, the exact breakpoints of the derivative chromosomes involved were determined at the cytogenetic level as 1q21 and 13q33 each.
Methylation of tRNA Asp by the DNA Methyltransferase Homolog Dnmt2 (2006)

The sequence and the structure of DNA methyltransferase-2 (Dnmt2) bear close affinities to authentic DNA cytosine methyltransferases. A combined genetic and biochemical approach revealed that human DNMT2 did not methylate DNA but instead methylated a small RNA; mass spectrometry showed that this RNA is aspartic acid transfer RNA (tRNA(Asp)) and that DNMT2 specifically methylated cytosine 38 in the anticodon loop. The function of DNMT2 is highly conserved, and human DNMT2 protein restored methylation in vitro to tRNA(Asp) from Dnmt2-deficient strains of mouse, Arabidopsis thaliana, and Drosophila melanogaster in a manner that was dependent on preexisting patterns of modified nucleosides. Indirect sequence recognition is also a feature of eukaryotic DNA methyltransferases, which may have arisen from a Dnmt2-like RNA methyltransferase.
Limited immune response conferred by an E2-CSFV expressing DNA vaccine after booster vaccination in murine models (2009)

To investigate if intradermal (ID) and intramuscular (1M) routes of vaccination result in a comparable expression of E2 gene of classical swine fever virus (CSFV), an established E2 DNA construct was tested in murine experimental models. Groups of six mice received three pcDNA+E2 immunisation each at weeks 0, 4 and 8 by either ID via gene gun delivery or 1M. Another second batch of six mice was immunised in a similar protocol with a plasmid cocktail of pcDNA+E2 and immunomodulators (pBOOST-rnIL4/mIL13). The findings showed that the 1M route was better in immune induction compared to the gene gun method. Apparently, on the basis of E2 expression in skin tissues via ID, ear targeting seemed to be better than the abdominal skin approach. With respect to the kinetics of anti-E2 antibody production, the antibody was not formed after one and two months after the DNA immunisation, but reached its detection level at 10 weeks post-immunisation. Variations were observed in the ability of the E2 expression plasmids to induce immune response in murine model when the humoral and cell-mediated immunity (CMI) was determined by ELISA and DTH trials, respectively. The adopted ID and 1M immunisation approaches gave distinct immune induction patterns in the presence and absence of cytokines. The findings indicate the enhancement of immune response after co-administration of these genetic immunomodulators with DNA vaccine against CSFV. However, the difference was insignificant (P>0.05) due to the high variance caused by the presence of non-responsive individuals.
Preference and Wearing Frequency of Knit-Wears Related to Self-Image (2008)

The purposes of this study were to investigate the relationships between women's self-image and the preference and the wearing frequency of knit-wears, and to examine the characteristics of the design elements that influence the preferred knit-wear images. The subjects were 277 female college students and working women living in metropolitan area of Seoul. The data were analyzed by using descriptive analysis, factor analysis, Cronbach's -reliability coefficient, Pearson's correlation coefficient, and multiple regression analysis. Four dimensions of women's self-images were derived by factor analysis; elegance, conservativeness, individuality, and maturity. Women with conservative self-image preferred simple knit-wears and women with high rate for individuality preferred splendid and sporty knit-wears. Women with elegant self-image disliked sporty knit-wears. Women with conservative self-image preferred white, and those who rated their self-image to be individuality preferred various colors including yellow, blue, green, purple, pink, and sky-blue. Women with mature self-image preferred black and beige. Women with individuality as their self-image preferred jacquard pattern and abstract pattern. There was a higher wearing frequency for all four seasons for women with conservative self-image, and there was higher wearing frequency in the winter for those with elegant self-images. Women who preferred simple knit-wears showed preference for single color with no prints and low chroma color, and those who preferred sporty knit-wears showed preference for elastic materials. Women who preferred neat and elegant knit-wears showed preference for argyle check pattern.
Minimally Invasive Total Knee Replacement through a Mini Midvastus Approach (2004)

Between September 2001 and September 2002, forty consecutive minimally invasive total knee replacements were done. A modified midvastus approach was used and the patella was subluxed, but not everted. We compared the results of this group with an age-matched and sex-matched cohort of total knee replacements done between June 2000 and September 2001 with a standard technique. A posterior-stabilized knee (Genesis II) was used in both groups. Patients achieved motion considerably faster in the minimally invasive total knee replacement group. Mean flexion for minimally invasive total knee replacement at 6 and 12 weeks was 114 degrees (range, 90-132 degrees ) and 122 degrees (range, 103-135 degrees ) respectively, compared with 95 degrees (range, 65-125 degrees ) and 110 degrees (range, 80-125 degrees ) for the control group. Improved range of motion was also seen at one year postoperatively. The average range of motion at one year postoperatively in the minimally invasive total knee replacement was 125 degrees (range, 110-135 degrees ) compared with 116 degrees (range, 95-130 degrees ) in the Control Group. Postoperative Knee Society scores were also higher in the minimally invasive total knee replacement group. There was no difference in xray alignment. There were no infections, extensor mechanism or neurovascular complications. The mini midvastus approach without patella eversion combined with a small incision was associated with a more rapid functional recovery and improved range of motion in total knee replacement without compromising implant positioning.
Mining Building Energy Management System Data Using Fuzzy Anomaly Detection and Linguistic Descriptions (2014)

Building Energy Management Systems (BEMSs) are essential components of modern buildings that are responsible for minimizing energy consumption while maintaining occupant comfort. However, since indoor environment is dependent on many uncertain criteria, performance of BEMS can be suboptimal at times. Unfortunately, complexity of BEMSs, large amount of data, and interrelations between data can make identifying these suboptimal behaviors difficult. This paper proposes a novel Fuzzy Anomaly Detection and Linguistic Description (Fuzzy-ADLD)-based method for improving the understandability of BEMS behavior for improved state-awareness. The presented method is composed of two main parts: 1) detection of anomalous BEMS behavior; and 2) linguistic representation of BEMS behavior. The first part utilizes modified nearest neighbor clustering algorithm and fuzzy logic rule extraction technique to build a model of normal BEMS behavior. The second part of the presented method computes the most relevant linguistic description of the identified anomalies. The presented Fuzzy-ADLD method was applied to real-world BEMS system and compared against a traditional alarm-based BEMS. Six different scenarios were tested, and the presented Fuzzy-ADLD method identified anomalous behavior either as fast as or faster (an hour or more) than the alarm based BEMS. Furthermore, the Fuzzy-ADLD method identified cases that were missed by the alarm-based system, thus demonstrating potential for increased state-awareness of abnormal building behavior.
Decreased T lymphocyte migration in patients with malignancy mediated by a suppressor cell population. (1984)

The migration and concentration of lymphocytes at sites of antigenic challenge are an integral part of the expression of delayed cutaneous hypersensi- tivity, as well as of tumor and graft rejection. In this study, we have analyzed the migration of T lymphocytes from patients with malignancy. We used casein and concanavalin A (Con A)-stimulated mononuclear cell su- pernatants to stimulate T cell locomotion. Peripheral blood T lymphocytes from 30 patients with established malignancy, 10 patients with indolent malignancy or benign tumor, and 42 normal adult controls were tested. Data are expressed as a migration index (MI), which rep- resents the difference in micrometers between the distance migrated in response to a stimulus and the distance mi- grated in response to media alone. We observed a marked depression in casein-stimulated T lymphocyte migration in patients with established malignancy (mean MI 1 SD = 17.09 um) as compared with normal adult controls (mean MI1 SD = 35.310 um). Similar results were observed with migration in response to Con A super- natants. T cells from patients with established malignancy had a mean MI of 5.84 Am to Con A supernatants as compared with 24.55 for controls. This depressed mi- gration was apparent both in the distance that cells mi- grated and in the number of cells that migrated into the membrane. Of 10 patients with indolent malignancy or benign tumor, T cell migration in 8 was not significantly decreased as compared with controls. When we mixed equal concentrations of normal control T lymphocytes with T lymphocytes from patients with cancer and added
Single-frequency pulse amplification in a higher-order mode fiber amplifier with fundamental-mode output (2013)

Single-frequency and narrow-linewidth pulse amplification is demonstrated in an erbium-doped higher-order mode fiber with effective area of 6000μm2 and output long-period grating for re-conversion of the output beam back to the fundamental mode.
Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans (2008)

The genomes of serotypes A, D, and AD strains exhibit extensive variation that spans the range from small differences (such as regions of divergence, deletion, or amplification) to the unexpected disomy for chromosome 13 in haploid strains and preferential retention of specific chromosomes in naturally occurring diploids.
TUNABLE ATOMIC LINE MOLECULAR SPECTROSCOPY OF BENZENE: SIGNALS WITH Hg 253.7 NM AND Co 252.8 NM LINES (1982)

Abs tractA method of locating appropriate atomic emission lines for the detection of complex molecules, e.g.benzene.with the TALMS technique is described.Atomic emission spectra are superimposed upon medium to high resolution absorption spectrograms of the molecules.It is then possible to calculate relative sensitivities associated with the various absorption features from the Zeeman splitting patterns and the absorption spectra.The TALMS signal is shown to be determined by the extinction coefficient difference, LE, a concentration independent parameter.L4 for benzene at the Co 252.8 nm and Hg 253.7 tim lines is estimated to be 100 and 8.4 respectively.The experimental TALMS signals using these lines are in the ratio 35:1. BRIEFA method of locating atomic emission lines for TALMS (tunable atomic line molecular spectroscopy) detection of complex molecules is described.TALMS signals for benzene are reported for the Co 252.8 nm and Hg 253.7 nm lines.
Impact of Sixteen Established Pancreatic Cancer Susceptibility Loci in American Jews (2017)

<b>Background:</b> The higher risk of pancreatic cancer in Ashkenazi Jews compared with non-Jews is only partially explained by the increased frequency of <i>BRCA1</i> and <i>BRCA2</i> mutations in Ashkenazi Jews.<b>Methods:</b> We evaluated the impact of 16 established pancreatic cancer susceptibility loci in a case-control sample of American Jews, largely Ashkenazi, including 406 full-Jewish pancreatic cancer patients and 2,332 full-Jewish controls, genotyped as part of the Pancreatic Cancer Cohort and Case-Control Consortium I/II (PanScan I/II), Pancreatic Cancer Case-Control Consortium (PanC4), and Resource for Genetic Epidemiology Research on Adult Health and Aging (GERA) datasets. We compared risk in full-Jewish subjects with risk in part-Jewish; non-Jewish Southern European; and in the combined non-Jewish Eastern, Northern, Southern, and Western European (non-Jewish white European) subjects from the same datasets. Jewish ancestries were genetically identified using seeded Fast principal component analysis. Data were analyzed by unconditional logistic regression, and adjusted for age, sex, and principal components.<b>Results:</b> One SNP on chromosome 13q22.1 (rs9543325; OR, 1.36; 95% confidence interval, 1.16-1.58; <i>P</i> = 10<sup>-4.1</sup>) was significant in full-Jews. Individual ORs and minor allele frequencies were similar between Jewish and non-Jewish white European subjects. The average ORs across the 16 pancreatic cancer susceptibility loci for full-Jewish, full- plus part-Jewish, non-Jewish Southern European, and non-Jewish white European subjects were 1.25, 1.30, 1.31, and 1.26, respectively.<b>Conclusions:</b> The 16 pancreatic cancer susceptibility loci similarly impact Jewish and non-Jewish white European subjects, both individually and as summary odds.<b>Impact:</b> These 16 pancreatic cancer susceptibility loci likely do not explain the higher risk seen in Ashkenazi Jews. <i>Cancer Epidemiol Biomarkers Prev; 26(10); 1540-8. ©2017 AACR</i>.
Etude structurale et magnétique de CoMnP3) (1980)

L'ordre cristallographique est complet dans CoMnP, c'est-à-dire le cobalt se situe en site tétraédrique et le manganèse en site pyramidal. La structure magnétique est essentiellement ferromagnétique de par l'arrangement des moments de manganèse (2,55 μB). L'introduction de manganèse dans les sites pyramidal puis tétraédrique de la solution solide Co2−xMnxP met en relation directe l'évolution des paramètres cristallographiques et les modifications importantes du magnétisme. In CoMnP the crystallographic ordering of manganese and cobalt is complete. Cobalt locates on tetraedral sites and manganese in pyramids, respectively. The magnetic structure is mostly of ferromagnetic type, essentially due to manganese magnetic ordering (M = 2.55 μB). Introduction of manganese in the pyramids and then in tetrahedra changes abruptly the cell parameters and magnetic properties in the Co2−xMnxP solid solution.
A view of fiber to the home economics (2004)

Fiber to the home in the U.S. market has not been deployed as rapidly as many had hoped or predicted. We examine some of the historical, competitive, and economic reasons for this. We argue that, from a competitive service perspective, it may be difficult to construct compelling business cases for large-scale deployment without either a technical need for fiber, or significant changes in either public policy or industrial organization.
LY121019 inhibits Neurospora crassa growth and (1-3)-.BETA.-D-glucan synthase. (1988)

Aculeacin A and echinocandin B are cyclopeptide antibiotics with a long-chain fatty acid (palmitic acid and linoleic acid, respectively1'"45) that are active against some yeasts and a few filamentous fungi4~9). Both aculeacin A and echinocandin B have been shown to affect cellwall synthesis5>8>10~12). Under in vitro conditions, aculeacin A and echinocandin B inhibit (l-3)-/3-glucan synthase activity: Aculeacin Anoncompetitive inhibitor, Geotrichum lactis, KhpV 60 //M13); Neurospora crassa, Ki&VJ> 12 ^M (C. S. Taft; unpublished results); echinocandin B -noncompetitive inhibitor, Candida albicans, J&app could not be determined145 ; uncompetitive inhibitor, N. crassa, Sapp 12 ^m15). These results have led to the attractive hypothesis that aculeacin A and echinocandin B exert their antifungal activity in vivo by inhibiting (l-3)-/3-D-glucan synthase (EC 2.4.1.34; UDP-Glucose: l,3-/3-D-glucan 3-/3-glucose transferase), thus
High-Velocity Hydrostatic Extrusion — A Feasibility Study (1973)

High velocities have been applied to small-scale hydrostatic extrusion to dispense with ram seals. An unsealed punch follower has been employed, at high impact velocities (20 ft/s), to extrude hydrostatically 1 in diameter billets of materials ranging from aluminium to high-speed steel, at an extrusion ratio of 2 through 90° dies, using various viscosity blends of Shell low viscosity index oil as pressure-transmitting media. An elementary analysis of the process was in qualitative agreement with the results, and highlighted the essential mechanics of the process.
DAVID-E: a collaborative working paradigm for distributed high-end audio-visual content creation (2003)

In recent years the world has witnessed an unprecedented expansion in the global audio-visual industry and actions have been initiated to strengthen its actors, especially in film making and video production. Companies seeking ways to improve their performance and productivity and become more competitive are investing in modern digital technologies. Very powerful high-performance computing systems are found today even in small production facilities. Yet, little effort has been made to implement activities other than production/post-production and even less, to integrate the whole cycle of content development and creation within a networked collaborative environment. This paper reports the experience of the DAViD project aiming to establish ways to interact and collaborate during pre-production phases. Several benefits have been demonstrated, such as reduction of the overall production time and cost, increased productivity and increased ability to execute complex, multi-company productions in shorter times and lower budgets.
The Thermally Regenerative Liquid-Metal Cell (1963)

The theory of a new, thermally regenerative, direct‐conversion device is described. The device depends on the reaction of two liquid metals to furnish energy, with subsequent thermal decomposition of the product into the original reactants. As an example, the emf of cells composed of varied from 0.45–0.38v at temperatures between 500° and 702°C and at mole fractions of Na in the alloy between 0.136 and 0.40. Experiments confirmed theoretical predictions that Na can be distilled from NaSn alloys at temperatures of 1000°–1100°C yielding a relatively pure Na vapor and an approximately 3% (wt) alloy residue.
Molecular Recognition between a New Pentacyclic Acridinium Salt and DNA Sequences Investigated by Optical Spectroscopic Techniques, Proton Nuclear Magnetic Resonance Spectroscopy, and Molecular Modeling (1999)

A pentacyclic acridine, 1H-2,3-dihydroindolizino[7,6,5-kl]acridinium chloride (1), related in structure to tetra- and pentacyclic marine natural products, has previously been shown to induce apoptosis in breast and non-small-cell lung tumor cell lines and shows significant differences in biological potency and antitumor profile from other intercalating agents based on the acridine framework. We report on the molecular recognition of the acridinium salt with DNA, quantified by optical spectroscopic methods, and have compared these results with the clinical agent amsacrine (m-AMSA). The results point to an intercalative association between 1 and G-C-rich sequences of DNA. We have synthesized a hexamer duplex d(ACGCGT)2, presenting two potential 5'-CpG recipient sites, and have investigated in detail by NMR and molecular modeling methods the orientational preferences of 1, particularly with regard to the pyrrolidine ring system. On the basis of the intermolecular nuclear Overhauser effect (NOE) data, four possible intercalation models were considered; no single model produced a significantly better fit than any of the others. The best fit to the experimental data was obtained by considering a dynamic equilibrium between the different intercalated orientations with the drug maximizing pi-overlap with the G-C base pairs at the intercalation site. We found little evidence for any degree of groove specificity imparted by the pyrrolidine ring. If these simulations have biological relevance they suggest that, at most, the agent induces only a transitory hot spot in the DNA which, evidently, is sufficient to be sensed by damage-recognition mechanisms of the cell.
The Principles of Antibody Therapy for Infectious Diseases with Relevance for COVID-19 (2021)

Antibody therapies such as convalescent plasma and monoclonal antibodies have emerged as major potential therapeutics for coronavirus disease 2019 (COVID-19). Immunoglobulins differ from conventional antimicrobial agents in that they mediate direct and indirect antimicrobial effects that work in concert with other components of the immune system. The field of infectious diseases pioneered antibody therapies in the first half of the 20th century but largely abandoned them with the arrival of conventional antimicrobial therapy. Consequently, much of the knowledge gained from the historical development and use of immunoglobulins such as serum and convalescent antibody therapies was forgotten; principles and practice governing their use were not taught to new generations of medical practitioners, and further development of this modality stalled. This became apparent during the COVID-19 pandemic in the spring of 2020 when convalescent plasma was initially deployed as salvage therapy in patients with severe disease. In retrospect, this was a stage of disease when it was less likely to be effective. Lessons of the past tell us that antibody therapy is most likely to be effective when used early in respiratory diseases. This article puts forth three principles of antibody therapy, namely, specificity, temporal, and quantitative principles, connoting that antibody efficacy requires the administration of specific antibody, given early in course of disease in sufficient amount. These principles are traced to the history of serum therapy for infectious diseases. The application of the specificity, temporal, and quantitative principles to COVID-19 is discussed in the context of current use of antibody therapy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).