gebhart/patrepeval huggingface dataset:
Integration of clinical trial development in hematology and oncology fellowship training: Washington university school of medicine experience. (2023)

11012 Background: Education in clinical trial design and development is highly variable among Hematology and Medical oncology fellowship programs. The Clinical Trial Development (CTD) program at Washington University in St. Louis (WUSM) is an experiential learning curriculum designed to provide a structured and personalized education to fellows about clinical investigation in Hematology and Oncology. We describe the results of the CTD program and its impact on subsequent academic faculty appointments. Methods: The CTD program was initiated at WUSM in 2002 as a hands-on learning experience for Hematology and Oncology fellows in the design, implementation, evaluation, and publication of clinical trials. Each fellow was required to identify a mentor in their first year of training and propose at least one CTD project, determined as a prospective investigator-initiated clinical trial involving human subjects or materials. Outcome data were collected from an internal registry of fellow CTD projects, Clinical Trials Management System (OnCore), PubMed, ClinicalTrials.gov and e-mail inquiries to fellows and mentors. Descriptive statistics were collected for the characteristics of CTD projects, including the phase of study, site (single center or multicenter), disease subtype, projects that received IRB approval, and projects that resulted in publication. Logistic regression and odds ratios (OR) were also used to assess the association between these characteristics and academic faculty appointments. Results: We included 118 fellows who began fellowship from 2002 to 2021 for this analysis with 16 still in training. Many trials were phase I/II (n = 53; 45%), phase I (n = 34; 29%) and phase II trials (n = 17; 14%) and most trials were single center studies (n = 93; 79%). Disease types of the investigations were evenly distributed between Oncology (n = 60, 51%) or Hematology (n = 58, 49%). Most fellows were successful in obtaining IRB approval for their CTD project (n = 93, 79%) and approximately two thirds of those with IRB approval went on to publish their results in peer-reviewed journals (n = 60, 65%). Forty-five percent of fellows who published their CTD projects were first authors (n = 27) and 38% published in journals with an impact factor of greater than 10. Among the graduating fellows, two-thirds (n = 67, 66%) secured an academic faculty appointment. Fellows with IRB approved CTD projects had significantly higher odds of obtaining an academic faculty appointment (OR 4.96, 95% CI 1.54-15.98, p &lt; 0.05). Conclusions: The CTD program is a well-established clinical investigation program for fellows with a track record of success and impact on subsequent academic faculty appointments. The CTD program is a model that other fellowship programs can emulate for education related to clinical trials.
A Systematic Investigation of Quaternary Ammonium Ions as Asymmetric Phase-Transfer Catalysts. Application of Quantitative Structure Activity/Selectivity Relationships (2011)

Although the synthetic utility of asymmetric phase-transfer catalysis continues to expand, the number of proven catalyst types and design criteria remains limited. At the origin of this scarcity is a lack in understanding of how catalyst structural features affect the rate and enantioselectivity of phase transfer catalyzed reactions. Described in this paper is the development of quantitative structure-activity relationships (QSAR) and -selectivity relationships (QSSR) for the alkylation of a protected glycine imine with libraries of quaternary ammonium ion catalysts. Catalyst descriptors including ammonium ion accessibility, interfacial adsorption affinity, and partition coefficient were found to correlate meaningfully with catalyst activity. The physical nature of the descriptors was rationalized through differing contributions of the interfacial and extraction mechanisms to the reaction under study. The variation in the observed enantioselectivity was rationalized employing a comparative molecular field analysis (CoMFA) using both the steric and electrostatic fields of the catalysts. A qualitative analysis of the developed model reveals preferred regions for catalyst binding to afford both configurations of the alkylated product.
MEMS based adaptive optics systems at the Naval Research Laboratory: an update (2007)

The use of adaptive and active optics (AO) is enabling the construction and test of flexible optical systems with performances unprecedented. This flourishing of technical advances is also due to the availability of new technologies that are much lower in cost, much easier to implement and use. Among these new technologies the use of Micro-Electro- Machined (MEM) mirrors is one of the primary sources of innovation. Several groups are actively working in bringing to fruition AO systems based on MEMs technologies and at the same time several groups are working to improve the MEMs technology and tailor it more and more towards various aspects of the AO problems. This technology is especially interesting to the Navy Prototype Optical Interferometer (NPOI) upgrade. In this field several AO systems have to be constructed and operated. It is of the outmost importance that each system has a less complex and costly approach than <i>classical</i> AO systems.
Counterfactual Conditionals in Quantified Modal Logic (2017)

We present a novel formalization of counterfactual conditionals in a quantified modal logic. Counterfactual conditionals play a vital role in ethical and moral reasoning. Prior work has shown that moral reasoning systems (and more generally, theory-of-mind reasoning systems) should be at least as expressive as first-order (quantified) modal logic (QML) to be well-behaved. While existing work on moral reasoning has focused on counterfactual-free QML moral reasoning, we present a fully specified and implemented formal system that includes counterfactual conditionals. We validate our model with two projects. In the first project, we demonstrate that our system can be used to model a complex moral principle, the doctrine of double effect. In the second project, we use the system to build a data-set with true and false counterfactuals as licensed by our theory, which we believe can be useful for other researchers. This project also shows that our model can be computationally feasible.
ATP4A autoimmunity in pediatric patients with type 1 diabetes and its relationship to blood count, iron metabolism, and vitamin B12 (2017)

ATP4A antibodies were present in a significant proportion of children with T1D. Higher ATP4A levels in T1D children are associated with lower, yet still fitting within the normal range, levels of vitamin B12, and ferritin. Routine screening of T1D children for gastric autoimmunity (ATP4A) should be considered with follow-up of those positive for vitamin B12 and iron deficiency.
Wastewater Standards and Extraction Chemistry in Validation of Microwave-Assisted EPA Method 3015A (1999)

The difficulties associated with the control and transfer of environmental leach methods are discussed. Optimized EPA Method 3015A, a microwave-assisted leach of wastewater and drinking water matrices and aqueous extracts, is evaluated. The option to add HCl in addition to HNO3 provides better complexation and recovery of certain metals that are regulated by the Resource Conservation and Recovery Act (RCRA) than the original HNO3-only Method 3015. Also discussed is the preparation and appropriate use of “simulated” wastewater standards. Standard reference materials for a wastewater matrix are unavailable, and this novel approach provides NIST-traceability of results for the first time on this matrix type. Leach concentrations from these “simulated” standards were determined using both the 5 mL HNO3 and the 4 mL HNO3 and 1 mL HCl leach options of new Method 3015A. Validation of the new mixed-acid option of Method 3015A has been provided by evaluating its performance on the 23 elements for which original Method 3015 was validated. In addition, validation is provided for boron, mercury, and strontium, elements that were not validated in original Method 3015. Method 3015A has been developed into a method capable of evaluating 26 elements in a single, efficient, 20-min procedure.
Three-Way Catalysts in a Hybrid Drive System: 1. Experimental Study of Dynamic Behavior (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThree-Way Catalysts in a Hybrid Drive System: 1. Experimental Study of Dynamic BehaviorLukas Padeste and Alfons BaikerCite this: Ind. Eng. Chem. Res. 1994, 33, 5, 1113–1119Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://doi.org/10.1021/ie00029a007RIGHTS & PERMISSIONSArticle Views102Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
High speed next generation passive optical networks: performance, cost, and power dissipation (2016)

The exponential growth of Internet data traffic pushes hard the telecommunication infrastructure for upgrading the transmission data rate. At the optical access level, a passive optical network (PON) is the most popular and lowest cost architecture which enables high speed access for enter prise and private users as well as various backhauling and fronthauling functionalities. Standardized PONs have undergone a number of upgrades in data rates. In order to guarantee a stable return of investment for operators, the co-existence of different generations of PONs on the same fiber infrastructure is ensured via a wavelength division multiplexing (WDM) approach. This leads to a spectrum shortage for future allocations if full co-existence is required. Today's fastest 40 Gb/s TWDM PONs [1] support 10 Gb/s lane rate non-return-to-zero (NRZ). Looking forward, the bandwidth demands continue to rise, thus increasing the per-wavelength bit rate is necessary for a future upgrade beyond 40 Gb/s. For such high data rates, the conventional NRZ format becomes demanding with respect to the required transceiver bandwidth and the acceptable fiber dispersion. As an alternative, advanced modulation formats and efficient signal processing can address the upgrade issue. Recently, research efforts have been focusing on 25 Gb/s or 40 Gb/s per wavelength next generation PONs using either NRZ with chirp management [2], or electrical/optical Duobinary [3-7], PAM-4 [3, 6-8], as well as more complex ODFM [9]. Considering PONs are cost-sensitive applications, intensity modulation and direct detection is highly desirable. Compared to DSP intensive OFDM, electrical/optical Duobinary and PAM-4 with low complex DSPs are potentially costeffective solutions. This paper aims to review and compare a number of implementation options for 40 Gb/s per wavelength high speed PONs using electrical/optical Duobinary and PAM-4. Optical link power budget performance, transceiver cost and power dissipation will be analyzed based on numerical approaches. Experimental demonstrations will also be presented.
The effect of the insecticide dichlorvos on esterase activity extracted from the psocids, Liposcelis bostrychophila and L. entomophila (2004)

The inhibition kinetics of dichlorvos on carboxylesterase and acetylcholinesterase (AChE) activity extracted from Liposcelis bostrychophila and L. entomophila (Psocoptera: Liposcelididae) were compared. The results showed that L. entomophila had significantly greater specific activity of carboxylesterase than L. bostrychophila (0.045 versus 0.012 µmoles /mg /min). Moreover, the carboxylexterase of L. entomophila showed higher affinity (i.e. lower Km value) to the substrate 1-naphthyl acetate than L. bostrychophila (0.29 versus 0.67 mM). The specific activity and affinity of AChE of the two species were not significantly different. The carboxylesterase of L. bostrychophila was more sensitive to the insecticide dichlorvos than that of L. entomophila. The I50s values of dichlorvos to carboxylesterase for L. bostrychophila and L. entomophila were 1.43 and 3.28 µM, respectively, and to AChE were 324 and 612 nM, respectively. Inhibition kinetics revealed that AChE from L. bostrychophila was 5.8-fold more sensitive to inhibition than AChE from L. entomophila.1-NA 1-naphthyl acetate AChE Acetylcholinesterase ATChI Acetylthiocholine iodide E3 carboxylesterse isozyme (E.C.3.1.1)
Annie Hogan: A survey (2008)

Review(s) of: Annie Hogan: A survey, by Curator: Frank McBride, Museum of Brisbane, 4 April - 6 July 2008.
Game of Sketches: Deep Recurrent Models of Pictionary-Style Word Guessing (2018)

The ability of machine-based agents to play games in human-like fashion is considered a benchmark of progress in AI. In this paper, we introduce the first computational model aimed at Pictionary, the popular word-guessing social game. We first introduce Sketch-QA, an elementary version of Visual Question Answering task. Styled after Pictionary, Sketch-QA uses incrementally accumulated sketch stroke sequences as visual data. Notably, Sketch-QA involves asking a fixed question ("What object is being drawn?") and gathering open-ended guess-words from human guessers. To mimic Pictionary-style guessing, we propose a deep neural model which generates guess-words in response to temporally evolving human-drawn sketches. Our model even makes human-like mistakes while guessing, thus amplifying the human mimicry factor. We evaluate our model on the large-scale guess-word dataset generated via Sketch-QA task and compare with various baselines. We also conduct a Visual Turing Test to obtain human impressions of the guess-words generated by humans and our model. Experimental results demonstrate the promise of our approach for Pictionary and similarly themed games.
Across-Depth Heterogeneity and Irreversibility of Fast-Charge-Driven Lithium Plating (2022)

Enabling fast charging in lithium-ion batteries (LIBs) is a key factor for resolving consumers’ “range anxiety” concerns in choosing an electric vehicle over a gasoline-powered one. The best-known issue in the fast charging of current LIBs (based on LiNi x Mn y Co 1−x−y O 2 /graphite) is lithium plating, which is barely reversible and is accompanied by capacity loss over time. Therefore, understanding the reasons for the irreversibility of lithium plating driven by fast charging is critical to enhancing the fast-charging capability of LIBs. Here, a study of the irreversibility and heterogeneity of lithium plating is carried out by using electrochemical analyses, inductively coupled plasma mass spectroscopy, and X-ray photoelectron spectroscopy. The study shows that the majority of the lithium plated during fast charging remains inactive even with very slow discharging rates, implying that most of the plated lithium is irreversibly lost. The study also reveals that chemical compounds such as LiF, Li 2 O and Li 2 (CO 3 ) are formed heterogeneously within the lithium plating and are responsible for some of the irreversibility of the plated lithium.
Technische Verfahren zur Synthese von Carotinoiden und verwandten Verbindungen aus 6‐Oxo‐isophoron. III. Ein neues Konzept für die Synthese der enantiomeren Astaxanthine (1981)

Technical Procedures for the Synthesis of Carotenoids and Related Compounds from 6‐Oxo‐isophorone. III. A New Concept for the Synthesis of the Enantiomeric Astaxanthins A new and efficient concept for the total synthesis of (3 S , 3' S )‐ and (3 R , 3' R )‐astaxanthin ( 1a and 1c , resp.) in high overall yield and up to 99,2% enantiomeric purity is described. Key intermediates are the ( S )‐ and ( R )‐acetals 10 and 17 , respectively (Scheme 2) . These chiral building blocks were synthesized via three different routes: a) functionalization of the enantiomeric 3‐hydroxy‐6‐oxo‐isophorons 4 ) 2 and 11 , respectively (Scheme 2) ; b) optical resolution of 3,4‐dihydroxy‐compound 4 ) 19 (Scheme 3) , and c) fermentative reductions of 6‐oxo‐isophorone derivatives (Schemes 4 and 5) . ‐ The absolute configurations of the two intermediates 12 and 13 (Scheme 2) have been confirmed by X‐ray analysis. ‐ The final steps leading to the enantiomeric astaxanthins are identical with those described for optically inactive astaxanthin [1].
Medical Evaluation and Triage of the Agitated Patient: Consensus Statement of the American Association for Emergency Psychiatry Project BETA Medical Evaluation Workgroup (2012)

Numerous medical and psychiatric conditions can cause agitation; some of these causes are life threatening. It is important to be able to differentiate between medical and nonmedical causes of agitation so that patients can receive appropriate and timely treatment. This article aims to educate all clinicians in nonmedical settings, such as mental health clinics, and medical settings on the differing levels of severity in agitation, basic triage, use of de-escalation, and factors, symptoms, and signs in determining whether a medical etiology is likely. Lastly, this article focuses on the medical workup of agitation when a medical etiology is suspected or when etiology is unclear.
Draft Genome Sequences of Eight Type Strains of the Genus Demequina (2015)

Here, we report the draft genome sequences of the type strains of Demequina aestuarii, Demequina aurantiaca, Demequina flava, Demequina globuliformis, Demequina lutea, Demequina oxidasica, Demequina salsinemoris, and Demequina sediminicola. The genome sequences presented here will facilitate taxonomical, ecological, and functional studies of members of the genus Demequina.
Effect of surface grafting coefficient and chain length of fatty acids on the luminescence of neodymium3+-doped LaF3 nanoparticles (2014)

Effect of chain length and surface grafting coefficient (<italic>ξ</italic>) of fatty acids on the luminescence intensity of LaF<sub>3</sub>:Nd<sup>3+</sup> nanoparticles were investigated.
Macrophages as novel cellular vehicles for gene therapy (2003)

Macrophages accumulate in pathological sites, including tumours, atherosclerotic plaques, arthritic joints and sites of infection. This fact led to the concept of introducing ex vivo genetically modified macrophages into a patient, where they would then ‘home’ to the sites of disease. For this novel and powerful approach to become a reality, the difficulty of efficiently transfecting macrophages and the tendency of transferred macrophages to locate to non-target sites must be overcome. Great progress has been made in the transfection of macrophages using viral vectors, and in the use of stably transfected CD34+ precursors of monocytes/macrophages, which could allow the bone marrow of patients with genetic disorders to be permanently enhanced with genetically modified cells. Lack of specificity in macrophage homing to diseased sites is proving to be a problem and will most likely need to be circumvented by the use of means such as disease- or site-specific transcriptional targeting to control expression of the therapeutic transgene.
RECLAMATION OF POLYPHENYL NUCLEAR REACTOR COOLANT BY SOLVENT TREATMENT (1963)

Laboratory studies were conducted to develop methods to reclaim degraded terphenyl nuclear reactor coolant. A solvent treatment process to reclaim high boiler or spent coolant is described. A preliminary evaluation of the reclamation process is presented. Technical evaluation of products as well as a theoretical analysis of the effects of reclaimed coolant on coolant decomposition rate and make-up rate is reported. A detailed description of all experimental work is also given.
exo-Selective acceleration of an intermolecular Diels–Alder reaction by a trimeric porphyrin host (1993)

A bimolecular Diels–Alder reaction is accelerated substantially and stereoselectively by binding diene and dienophile within the cavity of a cyclic metalloporphyrin trimer.
Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved (2004)

Recent studies suggest that RhoA and Rac1 mediate hypertrophic signals in cardiac myocyte hypertrophy. However, effects on cardiac function caused by inhibition of their activity in the heart have yet to be evaluated. Cardiac-specific inhibition of Rho family protein activities was achieved by expressing Rho GDIalpha, an endogenous specific GDP dissociation inhibitor for Rho family proteins, using the alpha-myosin heavy-chain promoter. Increased expression of Rho GDIalpha led to atrial arrhythmias and mild ventricular hypertrophy in adult mice (4-7 months). However, left ventricular systolic and diastolic function was largely preserved before and after the development of cardiac hypertrophy, indicating that Rho GTPases are not required to maintain ventricular contractile function under basal physiological condition. Electrocardiography and intracardiac electrophysiological studies revealed first-degree atrioventricular (AV) block in the transgenic heart at 1 week of age, which further progressed into second-degree AV block at 4 weeks of age before the development of cardiac hypertrophy. Expression of connexin 40 dramatically decreased from 1 week to 4 weeks of age in the transgenic heart, which may contribute in part to the conduction defects in the transgenic mice. This study provides novel evidence for an important role of Rho GTPases in regulating AV conduction.
Improving AWE accuracy using multipoint Pade approximation (1994)

A new method is proposed for dominant pole-zero analysis of large linear circuits containing both lumped and distributed elements. This method is based on a multipoint Pade approximation. It finds a reduced order s-domain transfer function using a data set obtained by solving the circuit at only a few frequency points. The proposed method yields more accurate computation of transient and frequency responses with respect to the asymptotic waveform evaluation (AWE) type techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Directed Self‐Assembly as a Route to Ferromagnetic and Superparamagnetic Nanoparticle Arrays (2014)

Block co‐polymer patterns are attractive candidates for nanoparticle assemblies. Directed self‐assembly of block co‐polymers in particular allows for long range ordering of the patterns, making them interesting scaffolds for the organization of magnetic particles. Here, a method to tune the channel width of polymer‐derived trenches via atomic layer deposition (ALD) of alumina is reported. The alumnia coating provides a much more thermally robust pattern that is stable up to 250 °C. Using these patterns, magnetic coupling in both ferromagnetic and superparamagnetic nanocrystal chains is achieved.
Traditional and Latest Researches on Aspergillus oryzae and Related Koji Molds (2021)

We would like to thank all the contributors to this Special Issue on <i>Aspergillus oryzae</i> and related <i>Koji</i> molds (https://www [...].