gebhart/patrepeval huggingface dataset:
Engineering Model for Hybrid Rocket Regression Rate Amplification by Helical Fuel Ports (2015)

This paper develops a semi-analytical engineering model developed to describe the effects of helical fuel ports on hybrid fuel regression rates. The centrifugal flow patterns introduced by the helical fuel port The model decomposes the regression rate amplification factor into two components 1) skin friction enhancement, and 2) wall blowing suppression. The skin friction enhancement due to the helical flow pattern is based on a correlation previously developed by Mishra and Gupta, modified to account for the diminishing helical centerline radius of curvature as the fuel port burns, and the port cross-section becomes increasingly more cylindrical. The radial blowing suppression is modeled as the ratio of the centrifugal force to the rate of momentum flow of the ablated fuel emanating from the port wall. Model predictions are compared to data collected for four different fuel grain geometries using gaseous oxygen and additively-manufactured acrylonitrile butadiene styrene as propellants. The comparisons are quite favorable. Model predictions are compared to test results. The resulting model has sufficient fidelity to allow optimization studies to be performed to optimize a variety of motor burn properties including shaped thrust profiles and minimum O/F shifts.
Abstract 3117: Molecular and clinical correlates of genetic ancestry in a diverse, admixed cancer dataset (2023)

Abstract The objective of this study is to determine whether genetic ancestry analysis can provide additional insight into the genetic determinants of cancer disparities distinct from socially constructed variables like self-reported race and ethnicity. The Oncology Research Information Exchange Network (ORIEN) “Avatar” project is a diverse dataset of extensive, longitudinal clinical and molecular data from 18 cancer centers across the U.S.; the ORIEN Intermember Ancestry Project cohort described in this study is a subset of the larger dataset. Using paired tumor/germline whole exome sequencing data from ORIEN, the Genome Aggregation Database (gnomAD) dataset of ancestry reference individuals, and the software tools ADMIXTURE and RFMix, we have estimated genetic ancestry for cancer cases from both ORIEN and The Cancer Genome Atlas (TCGA). The ORIEN dataset has 2.6X greater representation of self-reported Hispanic/Latinos than does TCGA, with Hispanic/Latinos making up 9% of the ORIEN dataset vs. 4% in TCGA. As expected, individuals of Hispanic/Latino ethnicity are heterogeneous in their admixture proportions of Indigenous American, African, and European ancestries. We performed statistical analyses in R to identify molecular and clinical correlations with ancestry. This study highlights the clinical utility of genetic ancestry analysis as an approach to understand the genetic contributions to cancer disparities in diverse, admixed populations. Citation Format: Mackenzie D. Postel, Jamie K. Teer, Steven A. Eschrich, Julie Dutil, Erin M. Siegel, William D. Cress, John D. Carpten, David W. Craig. Molecular and clinical correlates of genetic ancestry in a diverse, admixed cancer dataset [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3117.
StyleNet: Generating Attractive Visual Captions with Styles (2017)

We propose a novel framework named StyleNet to address the task of generating attractive captions for images and videos with different styles. To this end, we devise a novel model component, named factored LSTM, which automatically distills the style factors in the monolingual text corpus. Then at runtime, we can explicitly control the style in the caption generation process so as to produce attractive visual captions with the desired style. Our approach achieves this goal by leveraging two sets of data: 1) factual image/video-caption paired data, and 2) stylized monolingual text data (e.g., romantic and humorous sentences). We show experimentally that StyleNet outperforms existing approaches for generating visual captions with different styles, measured in both automatic and human evaluation metrics on the newly collected FlickrStyle10K image caption dataset, which contains 10K Flickr images with corresponding humorous and romantic captions.
3423 Theoretical Analysis of Critical Marangoni Number for Oscillatory Flows (2005)

Many experiments to determine the critical Marangoni number at the onset of oscillatory flows for high Prandtl number (Pr) fluids have showed a dependence of a characteristic length such as the diameter of the liquid column. This fact contradicts the similarity principle in fluid physics. The higher Pr fluid formed a thermal boundary layer with a steep temperature gradient in the vicinity of both the hot and cold disks for Marangoni convection experiments, although the middle of the free surface between the hot and cold disks has no temperature gradients. By considering the partial temperature distribution on the free surface, a basic model for the understanding of Marangoni number for higher Pr fluids is proposed by introducing a dimensionless parameter, the effective Marangoni number. Experimental results obtained from microgravity experiments showed that this effective Marangoni number does not have the characteristic length dependence at the onset of oscillatory flows. This parameter is consistent with the similarity principle in Marangoni convection behavior.
Layer-by-Layer Assembly of Photonic Crystal Using DNA (2011)

Photonic crystal is a key component for optical communication and computing in next generation that having a periodic 3D structure in scale with optical wave length. The major difficulty in practical use of photonic crystal exists in its fabrication process. As an optical component, it must be a defect-free large crystal with waveguide patterns affecting propagation of photons. Many attempts have been made to realize such a crystal, however, low-cost and rapid fabrication of a defect-free large crystal is still a difficult problem. Here, we propose a novel fabrication method combining colloidal crystallization and DNA nanotechnology. In this method, the face-centered lattice made of 1µ m polystyrene particle is assembled on a patterned template in a layer-by-layer fashion. In order to control the binding among particles, DNA-gold nanoparticle conjugates (10nm GNP modified with 52-mer DNA) is used. Specific bonding rules between particles and GNPs defined by base sequence of DNA realizes the layer-by-layer growth of the crystal. We have built two-layer crystal by the proposed method and the results show its feasibility. We also found some important factors necessary to improve the quality of the crystal.
SPUU-PEO-heparin graft copolymer surfaces. Patency and platelet deposition in canine small diameter arterial grafts. (1992)

The influence of an SPUU-PEO-Heparin (B-PEO-HEP) copolymer coated blood contacting surface on patency and platelet deposition in small diameter (4 mm i.d.) Biomer grafts was investigated using a canine model. Grafts were implanted in the bilateral carotid and femoral arteries. B-PEO-HEP coated grafts still showed patency after 3 days. Control Biomer grafts occluded before 24 hr. (postoperatively). SEM of the luminal surfaces of the Biomer grafts demonstrated large amounts of adherent platelets with distorted morphologies, while B-PEO-HEP grafts did not. In platelet studies, B-PEO-HEP grafts showed significantly less platelet adhesion than Biomer grafts. The improved blood compatibility of B-PEO-HEP graft co-polymer coatings attests to their usefulness for coating or casting.
Yield limit analysis of particle motion in a yield-stress fluid (2017)

A theoretical and numerical study of yield-stress fluid creeping flow about a particle is presented. Yield-stress fluids can hold rigid particles statically buoyant if the yield stress is large enough. In addressing sedimentation of rigid particles in viscoplastic fluids, we should know this critical ‘yield number’ beyond which there is no motion. As we get close to this limit, the role of viscosity becomes negligible in comparison to the plastic contribution in the leading order, since we are approaching the zero-shear-rate limit. Admissible stress fields in this limit can be found by using the characteristics of the governing equations of perfect plasticity (i.e. the sliplines). This approach yields a lower bound of the critical plastic drag force or equivalently the critical yield number. Admissible velocity fields also can be postulated to calculate the upper bound. This analysis methodology is examined for three families of particle shapes (ellipse, rectangle and diamond) over a wide range of aspect ratios. Numerical experiments of either resistance or mobility problems in a viscoplastic fluid validate the predictions of slipline theory and reveal interesting aspects of the flow in the yield limit (e.g. viscoplastic boundary layers). We also investigate in detail the cases of high and low aspect ratio of the particles.
Dosismodifikation von Ribavirin bei nicht vorbehandelten und bei vorbehandelten Patienten, die eine Telaprevir (T) Kombinationsbehandlung erhielten: Kein Einfluss auf das anhaltende virologische Ansprechen (SVR) in klinischen Studien der Phase III (2012)

Hintergrund: Sicherheit/Wirksamkeit von T bei therapienaiven Patienten (Pat) (ADVANCE/ILLUMINATE) u. vorbehandelten Pat (REALIZE) mit HCV Genotyp 1 Virusinfektion wurden in 3 Phase-3-Studien evaluiert; Eine Anämie war bei Pat mit T-basierter Therapie häufiger. In retrospektiven Subanalysen wurden die Ergebnisse anhand der Ribavirin (R)-Dosisreduktion in beiden Populationen getrennt beurteilt.
Assister le désir d’enfant de couples séropositifs pour le VIH ? (2000)

Carte blanche
Return Predictability and Dynamic Asset Allocation: How Often Should Investors Rebalance? (2014)

To exploit return predictability via dynamic asset allocation, investors face the important practical issue of how often to rebalance their portfolios. More frequent rebalancing uses statistically and economically significant short-horizon return predictability to aggressively pursue the dynamic investment opportunities afforded by changes in expected returns. However, the degree of return predictability typically appears stronger at longer horizons, which, along with lower transaction costs, favors less frequent rebalancing. The authors analyze the performance effects of rebalancing frequency in the context of dynamic portfolios constructed from monthly, quarterly, semi-annual, and annual return forecasts for U.S. stocks, bonds, and bills, where the dynamic portfolios rebalance at the same frequency as the forecast horizon. Along the transaction-cost/rebalancing frontier, monthly (annual) rebalancing provides the greatest outperformance when unit transaction costs are below (above) approximately 50 basis points, and dynamic portfolios based on annual rebalancing typically outperform the benchmarks for unit transaction costs well in excess of 400 basis points. <b>TOPICS:</b>Portfolio theory, statistical methods, portfolio construction
Abstract 4339: Single cell RNA sequencing dissects cellular growth factor dependencies and oncogenic driver effects in an organoid model of gastric cancer (2017)

Abstract Gastric cancer is a lethal malignancy with few therapeutic options. Gastric tumors rely on complex intercellular signaling “crosstalk” that enables tumor development, metastasis, and therapeutic resistance. To recapitulate the intercellular communications among various cell populations that exist in vivo, we are using a three-dimensional culture system to grow and manipulate mouse gastric tissue in vitro, otherwise referred to as organoids. Importantly, this organoid model contains epithelium with its endogenous mesenchymal niche and does not require exogenous Wnt stimulation. To systematically analyze the distinct cellular lineages and their interactions, we applied a massively-scaled single cell RNA-Seq platform to sequence thousands of individual cells from organoid cultures. With PCA and t-SNE analysis of the high-dimensional data generated from single cell RNA-seq, we characterized two major cell types, i.e. epithelial and mesenchymal cells. Leverage the information from single cell transcriptome profiles, we identified specific niche factors of the Wnt signaling pathways that are activated in different stomach cell lineages. These results suggest that the mesenchymal cell populations provide a potential source of the R-spondin, a Wnt agonist, that sustains the growth of epithelium. Furthermore, we compared cell populations from Cdh1-/-/Trp53-/- and Trp53-/-organoids, and characterized changes on the transcriptome profiles due to the loss of Cdh1, an early oncogenic event in diffuse gastric cancer development. Overall, using organoid model and high-throughput single cell RNA-Seq provides a novel approach to study early tumor transformation and critical cancer-stroma interactions. Citation Format: Jiamin Chen, Noemi Andor, Susan M. Grimes, Billy Lau, Hanlee P. Ji. Single cell RNA sequencing dissects cellular growth factor dependencies and oncogenic driver effects in an organoid model of gastric cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4339. doi:10.1158/1538-7445.AM2017-4339
Coal solubility and swelling. 1. Solubility parameters for coal and the Flory .chi. parameter (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoal solubility and swelling. 1. Solubility parameters for coal and the Flory .chi. parameterPaul C. Painter, John Graf, and Michael M. ColemanCite this: Energy Fuels 1990, 4, 4, 379–384Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/ef00022a008https://doi.org/10.1021/ef00022a008research-articleACS PublicationsRequest reuse permissionsArticle Views302Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
All-fiber system for simultaneous interrogation of distributed strain and temperature sensing by spontaneous Brillouin scattering (2000)

We demonstrate a low-loss, long-range, single-ended distributed optical fiber sensor to measure both temperature and strain simultaneously and unambiguously. By using the Landau¿Placzek ratio and cascaded Mach¿Zehnder interferometric filters, we measure both the intensity and the frequency changes in the Brillouin backscattered signal. Strain and temperature measurements can then be independently resolved. A temperature resolution of 4 degrees C, a strain resolution of 290 muepsilon, and a spatial resolution of 10 m have been achieved for a sensing length of 15 km.
IP-10 and Type 1 Diabetes: A Question of Time and Location (2004)

Chemokines are key signal molecules that attract cells of the host immune system to the site of a potential threat. Virus infections usually induce a massive chemokine and cytokine burst and therefore recruit a large plethora of leukocytes to the site of infection with the goal to restrict and abrogate viral spread. The down side of this massive excitation of the human defense system is non-specific activation of potentially self-reactive lymphocytes. Coupled with an antigen-specific event, for example molecular mimicry between host commponents and viral proteins, autoimmunity might be the consequence in susceptible individuals. However, activated immune components with autoaggressive potential must find their target and must remain in one site sufficiently long in order to cause chronic tissue damage. In this review we will focus on the influence of the chemokine IP-10 (CXCL10) on the trafficking of autoaggressive cells during the immunopathogenesis of type 1 diabetes (T1D) and explain why IP-10 can have a dual effect on T1D depending on time and location of expression.
NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells v1 (2021)

The mechanistic basis of gliogenesis, which occurs late in human development, is poorly understood. Here we identify nuclear factor IA (NFIA) as a molecular switch inducing human glial competency. Transient expression of NFIA is sufficient to trigger glial competency of human pluripotent stem cell-derived neural stem cells within 5 days and to convert these cells into astrocytes in the presence of glial-promoting factors, as compared to 3–6 months using current protocols. NFIA-induced astrocytes promote synaptogenesis, exhibit neuroprotective properties, display calcium transients in response to appropriate stimuli and engraft in the adult mouse brain. Differentiation involves rapid but reversible chromatin remodeling, glial fibrillary acidic protein (GFAP) promoter demethylation and a striking lengthening of the G1 cell cycle phase. Genetic or pharmacological manipulation of G1 length partially mimics NFIA function. We used the approach to generate astrocytes with region-specific or reactive features. Our study defines key mechanisms of the gliogenic switch and enables the rapid production of human astrocytes for disease modeling and regenerative medicine.
The Case for Polypharmacy in the Treatment of Bipolar Disorder (2007)

Bipolar disorder is often accompanied by a host of other medical and psychiatric comorbidities. Recent evidence suggests that the illness is not as benign as originally considered . . .
Catecholaminergic innervation of the inner ear (1990)

Cochlear blood flow has been shown to be controlled, in part, by the sympathetic nervous system. We have used immunocytochemical staining for tyrosine hydroxylase (TH) to further demonstrate the extent of catecholaminergic innervation of the cochlea. Deeply anesthetized Mongolian gerbils were systemically perfused with phosphate-buffered saline, followed by 4% paraformaldehyde. The cochleae were dissected out and post-fixed for 3 hours in 4% paraformaldehyde. They were then incubated in anti-TH antibody and subsequently processed using the avidin-biotin immunoperoxidase method. Microscopic examination of whole-mounted tissue revealed many immunoreactive fibers on the spiral modiolar artery. TH-positive fibers have also been found on both radiating arterioles and radial collecting venules, which has not been previously reported. With innervation of these small vessels, blood flow in the cochlea may be segmentally controlled. We also further describe the organization of TH-positive fibers in the osseous spiral lamina.
Efficient Visibility Determination in Urban Scenes Considering Terrain Information (2017)

In this article, we introduce a novel occlusion culling method working on the server side to provide real-time navigation on web-based systems. Nowadays, virtual navigation in urban environments is a rising trend in several contexts such as tourism, GPS navigation systems, and video games. A city environment is usually associated with a complex data model that is better stored, maintained, and updated on a server system. Mobile devices are regular clients in these cases, demanding this information in a fast, reliable, and engaging way. Even though these gadgets have been increasing their capabilities in computation and visualization, the bottleneck is still the transmission of information over the network. The advantage of urban environments is that, from a user viewpoint, only a small portion of the scene is visible. This feature makes crucial the use of occlusion culling techniques working on the server side in order to transmit to the client side only the small set of visible elements compared to the whole scene. The input data are the city geometry from the 2D cadastral information system, the building textures, and DEM (Digital Elevation Model) files with the urban terrain features. In a first stage, the process creates a 2.5D urban model with all these data in preprocessing time. Then the client provides the user location point, and the server sends back the exact portion of visible city. This approach is implemented using polar diagrams for visibility determination and LOD (Level of Detail) techniques for further geometry reduction.
Clinical implications of the morphological features of left ventricular intracavitary thrombi after anterior ST elevation myocardial infarction (2021)

Abstract Funding Acknowledgements Type of funding sources: None. Background Left ventricular thrombi (LVT) after an anterior ST elevation myocardial infarction (STEMI) are usually classified as protruding or laminar according to their morphological characteristics. However, it is unknown whether this morphology has any clinical implication. Purpose Determine prognostic between laminar or protruding LVT in the community of anterior STEMI. Methods An observational cohort study on patients with LVT after anterior STEMI detected by echocardiography between 2008 and 2019 was conducted. Laminar LVT was defined as those protruding &amp;lt;5mm inside the cavity. Results Of 1.215 anterior STEMI patients, 121 (10%) cases presented LVT: 86 (71%) were protruding and 35 (29%) laminar. Mean follow-up was 323 ± 116 days. No differences in baseline clinical and echocardiographic characteristics were detected between both groups. However, protruding LVT patients were more frequently treated with triple therapy (71% vs 40%; p &amp;lt; 0.001). Laminar LVT patients presented a lower stroke rate (3% vs 16%; P = 0.042) and embolism-related rate (3% vs 19%; p = 0.024) than protruding LVT cases (see Figure). Laminar LVT was associated with lower embolism-related events during follow-up independently than left ventricular ejection fraction (LVEF) and age (OR = 0.11; 95% CI,0.12-0.94; p = 0.045). No differences were observed in laminar LVT patients in embolism-related events during follow-up between those treated with or without triple therapy (7% vs 0%; p = 0.400). Conclusions Laminar LVT after anterior STEMI presented a lower rate of embolism-related complications during follow-up compared with protruding LVT regardless of LVEF, age and even with a lower rate of triple therapy. Abstract Figure.