gebhart/patrepeval huggingface dataset:
Role of free oxygen radicals in the development of gastrointestinal mucosal damage in Escherichia coli sepsis. (1985)

Live Escherichia coli were infused into anesthetized cats given 0.6 ml bile/kg and 80 mM HCl into the stomach. Systemic and pulmonary arterial blood pressures, cardiac output, and gastric blood flow were monitored. Gastrointestinal total wall and mucosal blood flow were measured by microspheres. The microscopic mucosal damage was graded 0-4 (stomach) or 0-5 (intestine). One group of cats (N = 8) received 5 mg yeast CuZn superoxide dismutase (SOD) as a bolus before bacteria followed by infusion 50 mg/3 hr. Four of these cats were also given catalase in the same dose. Controls (N = 8) had no treatment. After 3 hr gastric ulceration (grades 2-4) was found in controls but only in 50% of treated cats (P less than 0.1). About 50% and 25% of the cats in both groups developed significant small intestinal and colonic mucosal damage, respectively. SOD or SOD/catalase had no effect on late systemic hypotension, decrease in cardiac output, or transient increase in pulmonary pressure. Total gastric blood flow did not change, while at late sepsis gastric mucosal flow was decreased in the treated group. Small intestinal mucosal flow decreased in both series. It is concluded that free oxygen radicals may be of partial importance in the development of sepsis-induced gastric, but not intestinal, mucosal damage.
Interactions between query optimization and concurrency control (2003)

The author argues the importance of and need for taking into consideration concurrency control related issues in making query optimization and query processing decisions. Such considerations are very important not only for attaining good performance, but also for assuring the correctness of the results returned to the users under certain circumstances. Some of the topics that they deal with include degrees of consistency or isolation levels (repeatable read, cursor stability, . . .), lock escalation, blocking of results and use of multiple indexes for a single table access (i.e. index AND/ORing). They identify some of the pieces of information relating to locking that must be available to the optimizer for it to make intelligent decisions. They also identify some situations in which locking can be avoided by taking advantage of the isolation level of the query being executed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Effect of vitamin-enriched bread on the vitamin status of an isolated rural community--a controlled clinical trial. (1996)

Malnutrition is an inclusive term that entails the lack, excess or imbalance of one or more nutrients required to maintain normal nutritional status and optimal health. Malnutrition affects a large segment of the world's children. 1 It is estimated that the prevalence of childhood malnutrition in South Africa ranges from 5% to 50% of the current poputation.2 It is well documented that an inadequate intake of micronutrients causes deficiency disorders and that such deficiencies often accompany malnutrTtion. 3 The dietary intake of calcium, iron, zinc, folic acid, riboflavin, vitamin 86 and vitamin C has been reported to be low, in comparison with the recommended dietary allowances (RDA),4 in a significant proportion of children in the country; it is often lower than 67% of the RDA, indicating a population at risk of deficiency.s» In adults 15 - 64 years of age, the dietary intake of such micronutrients as vitamin 8 6 , iron, calcium, magnesium, zinc, copper and folic acid has also been reported to be significantly lower than the RDA.S,S Fortification of food staples has been successfully implemented in a number of countries to increase the dietary intake of micronutrients. 7
Fibromatose Agressiva do tipo Desmoide - Revisão Pictórica (2018)

Fibromatoses agressivas do tipo desmoide consistem em tumores mesenquimatosos raros que se caraterizam histologicamente por proliferação de fibroblastos e miofibroblastos. Apresentam comportamento intermédio, com tendência a comportamento infiltrativo e recidivante, sem capacidade metastização. Podem localizar-se na parede abdominal, ou em topografia intra ou extra-abdominal. A RM oferece vantagens na avaliação e estadiamento das lesões, evidenciando massas heterogéneas bem ou mal definidas, com sinal intermédio nas sequências ponderadas em T1 e T2, centradas ao plano inter-muscular, com bandas de hipocaptação interna (bandas de colagéneo), e que geralmente exibem halo de gordura (“split fat” sign), e extensão aos planos fasciais (“fascial tail” sign). Lesões com maior intensidade de sinal T2 apresentam maior probabilidade de recorrência. Na ausência de excisão cirúrgica, total ou parcial, a diminuição da intensidade do sinal T2, redução dimensional e a ausência de captação de contraste são características que sustentam eficácia terapêutica.
Intra-articular hyaluronate, tenoxicam and vitamin E in a rat model of osteoarthritis: evaluation and comparison of chondroprotective efficacy. (2015)

Intra-articular application of HA, tenoxicam and Vit E are chondroprotective in early osteoarthritis model in rats. Chondroprotective activity of tenoxicam and Vit E are comparable with the beneficial effects of HA on articular cartilage.
Dynamics of Coupling Peaks by H2 Diffusion in Long-Period Grating Filters (1997)

It is now well known that germanium-doped silica fibers excellent photosensitivity. A UV source changes the refractive index of the core that contains germanium. A common type of defect formed in germanium-doped silica is GeO or oxygen deficient germania related defect [1], which is bonded to three oxygen atoms, and one bond is made to a silicon/germanium atom. This has been identified as giving rise to absorption centered around 240 nm. But, typically UV induced index changes have been limited to 3×10 −5 for standard single mode fibers doped with 3% germania [2]. Increasing GeO 2 doping concentration and reducing the amount of oxygen used in the fabrication of the preform also enhance the fiber photosensitivity [2]. In this case, the peak index changes are usually about 5×10 −4 or less. More recently, two techniques have been proposed to enhance the photosensitivity of germanium-doped silica fibers : exposure of the material to the flame of an oxygen-hydrogen burner(flame brushing method) [3], and hydrogen loading at low temperature and high pressures [4]. Lemaire [4] showed 5.9×10 −3 peak-to-peak index change in the case of 3% GeO 2 loaded with 3.3% H 2 . In long-period grating filter fabrication, hydrogen treatment is needed to get high Δn for coupling a fundamental guided mode to the cladding leaky modes efficiently. Hydrogen treated germano-silicate fiber is unstable because of H 2 diffusion process. We present the growth and decay behavior of the coupling peaks induced by H 2 diffusion and annealing process for stabilization.
Evaluation of Recombinant Human Factor IX: Pharmacokinetic Studies in the Rat and the Dog (1995)

The pharmacokinetics of intravenously administered recombinant human factor IX (rhFIX) were studied in Sprague-Dawley rats and Beagle dogs. Rats received rhFIX (50 IU/kg once daily) for 28 days, and the plasma half-life was 5 h. Anti-Human Factor IX serum antibody levels were found in only 1 of 12 rats. The pharmacokinetic profiles of rhFIX or Mononine, a purified human plasma-derived factor IX, after single 100 IU/kg i.v. doses in dogs, were similar. Peak plasma concentrations of rhFIX and Mononine were 4-5 micrograms/ml. The mean plasma half-lives were 13.2 +/- 1.6 h for rhFIX and 13.3 +/- 1.6 h for Mononine. Dogs also received rhFIX (40 IU/kg i.v., daily) for 28 days or Mononine (40 IU/kg i.v. daily) for 14 days. Anti-human Factor IX serum antibody levels were determined for each compound. Pharmacokinetic half-lives decreased in these treated dogs which developed antihuman Factor IX antibodies. The antibody responses in 28 day rhFIX (40 IU/kg) dogs were similar to 14 day Mononine (40 IU/kg) dogs.
On the role of N‐7‐mercaptoheptanoyl‐O‐phospho‐L‐threonine (component B) in the enzymatic reduction of methyl‐coenzyme M to methane (1987)

The reduction of methyl-coenzyme M (CH3SCoM) to methane in methanogenic bacteria is dependent on component B (N-7-mercaptoheptanoyl-O-phospho-L-threonine, HSHTP). We report here that S-methyl-component B (N-7-(methylthio)heptanoyl-O-phospho-L-threonine, CH3SHTP) can substitute for neither CH3SCoM nor HSHTP in the methyl-CoM reductase reaction. Rather, CH3SHTP proved to be an inhibitor competitive with HSHTP (apparent Ki = 6 microM) and noncompetitive with CH3SCoM. These results make it very unlikely that HSHTP functions as a methyl group carrier. A role for HSHTP as direct electron donor for CH3SCoM reduction to CH4 is proposed.
Simultaneous determination of alpha-emitting nuclides of radium through californium in large environmental and biological samples (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimultaneous determination of alpha-emitting nuclides of radium through californium in large environmental and biological samplesClaude W. Sill, Forest D. Hindman, and Jesse I. AndersonCite this: Anal. Chem. 1979, 51, 8, 1307–1314Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/ac50044a043https://doi.org/10.1021/ac50044a043research-articleACS PublicationsRequest reuse permissionsArticle Views113Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Table S4 from Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence (2023)

&lt;p&gt;Top10 DEGs in scRNA-seq clusters&lt;/p&gt;
Differential Diagnosis of Acute Flaccid Paralysis and its Role in Poliomyelitis Surveillance (2000)

Acute (AFP) is a clinical syndrome characterized by rapid onset of weakness, including (less frequently) weakness of the muscles of respiration and swallowing, progressing to maximum severity within several days to weeks. The term flaccid indicates the absence of spasticity or other signs of disordered central nervous system motor tracts such as hyperreflexia, clonus, or extensor plantar responses (1). When applied to voluntary muscles, paralysis means loss of contraction due to interruption of motor pathways from the cortex to the muscle fiber. It is preferable to use the term paresis for slight loss of motor strength and paralysis or plegia for severe loss of motor strength (1). The differential diagnosis of AFP varies considerably with age. No single operational clinical case definition of AFP or paralytic poliomyelitis that combines both high sensitivity and high specificity has emerged (2-4). The currently used case definition increases sensitivity in detecting the existence of AFP but tends to decrease specificity in detecting paralytic poliomyelitis.
Imaging focused x-rays from glass capillaries (1996)

Recent developments of glass capillaries allow x-ray probes to be focused down to micrometer sizes. These probes show promise for microanalysis applications, if they can reliably deliver high intensity, well formed x-ray beams to a specimen. We have developed an optical bench for viewing and evaluating the focused x-rays emitted from these capillaries. The optical bench allows pulse counting, direct viewing of the x-ray probe spatial distributions, and energy pass band by using exchangeable detectors. Our results are used to determine the probe forming capabilities of the lenses and to indicate problems and directions for improving the manufacturing of the x-ray optics. The x-ray optical bench is shown in a schematic diagram in figure A. It consists of a conventional CuKα x-ray diffraction tube joined to an optical table. An optical rail extends across them. A shielded box with a hinged side covers the source and the optical rail. The x-ray optic and exchangeable detector system are located on computer controlled stages to allow fine adjustments in all necessary translation and tilt directions. This optical bench permits measurements to be devised, performed, and changed with a minimum of difficulty. The optical bench allows for maximum flexibility in sample positioning, detector positioning, source size, and source collimation. The quantities that we evaluate in each optical element include focal spot size, spot uniformity, total spot flux, spot aberrations, diffuse scattered radiation, and depth of field or convergence.
Lack of chronic toxicity and carcinogenicity of dietary administrated catechin mixture in Wistar Hannover GALAS rats (2011)

Chronic toxicity and carcinogenicity of catechin mixture were examined in Wistar Hannover GALAS rats. Administration was in the diet at concentrations of 0, 0.02, 0.3, 1 or 3%. Slight increases in relative liver weight and centrilobular hypertrophy of hepatocytes associated with induction of CYP3A2 were found at the 3% in males of both studies. However, because there were no signs indicative of hepatotoxicity on serum biochemical and histopathological examinations, the changes observed in the liver were regarded as adaptation, and not adverse effects. The slight depressions of body weights at the 3% in females of the chronic toxicity study and in both sexes of the carcinogenicity study were observed. These decreases were because the diet at the highest concentration was frangible and nominal food consumption may not have reflected the actual food consumption resulting in decrease in caloric intake, rather than toxic effects. Thus it was concluded that catechin mixture had no toxicity. In addition, tumor incidences and types were comparable between treated and control groups. Based on the results, the no observed adverse effect levels estimated from the chronic toxicity study were 3% in both sexes equal to 1922.9 in males and 2525.7 mg/kg/day in females. Catechin mixture has no carcinogenic potential in male and female rats.
Antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugated with polyglutamic acid and its derivative. (1984)

Four types of 1-beta-D-arabinofuranosylcytosine (ara-C) conjugates with poly-L-glutamic acid (PLGA) or poly-N5-(2-hydroxyethyl)-L-glutamine (PHEG) were prepared in an attempt to enhance the efficacy of the drug in simple dosage schedules. The conjugates were made by linking ara-C to the carboxyl groups of PLGA directly at N-4 of ara-C (ara-C:PLGA) or indirectly through the 2-aminoethylphosphoryl or 6-aminohexylphosphoryl side chain which had been introduced to C-5' of ara-C, 1-[5'-(2-aminoethylphosphoryl)-beta-D-arabinofuranosyl]cytosine: PLGA [araCMP(C2):PLGA and 1-[5'-(6-aminohexylphosphoryl)-beta-D-arabinofuranosyl]cytosine:++ +PLGA, respectively, or made by converting the remaining carboxyl groups in the PLGA conjugates to the 2-hydroxyethylamide groups [ara-C:PHEG, ara-CMP(C2):PHEG, 1-[5'-(6-aminohexylphosphoryl)-beta-D-arabinofuranosyl]cytosine:++ +PHEG]. Studies in vitro showed that the conjugates had decreased cytotoxicity against L1210 cells when compared with that of ara-C. Studies in vivo showed that all of the conjugates, except ara-CMP(C2):PLGA, had a greater antitumor activity than did ara-C in L1210 tumor-bearing BALB/c X DBA/2 F, (hereafter called CD2F1) mice (inoculum, 1 X 10(5) cells i.p. on Day 0) which were treated by a single i.p. injection of either the conjugates or the control ara-C on Day 1. The largest antitumor activity [increased life span (ILS) 170%] was observed with a dosage of 50 mg (equivalent ara-C per kg) of ara-C:PHEG. When CD2F1 mice which had been inoculated i.p. with 1 X 10(5) L1210 cells were treated with an i.p. injection of 12.5 or 25 mg (equivalent ara-C per kg) of ara-C:PHEG daily for 5 days starting from Day 1, 2 of 5 mice survived more than 42 days, and the ILS of the remaining mice was 153 and 184%. The injections of 3.2 mg (equivalent ara-C per kg) of ara-C:PHEG showed a moderate antitumor activity with an ILS of 113% which was similar to the ILS (119%) found when unconjugated ara-C (400 mg/kg) was used to treat tumor-bearing mice. In in vitro release experiments, ara-C was released slowly from ara-C:PLGA at pH 7.4, and ara-CMP(C2):PLGA was chemically stable but cleaved by phosphodiesterase, acid phosphatase, and alkaline phosphatase to give mainly 1-beta-D-arabinofuranosylcytosine 5'-monophosphate.
New endomorphin analogs with mu-agonist and delta-antagonist properties (2004)

Abstract Endomorphins (endomorphin-1,H-Tyr-Pro-Trp-Phe-NH 2 ,endomorphin-2, Tyr-Pro-Phe-Phe-NH 2 ) are potent and selective µ-opioid receptor agonists. In order to improve the affinity and chemical stability of endomorphins, we have designed, synthesized, and characterized novel analogs with unnatural (2 ',6 '-dimethyltyrosine, Dmt) and/or ß-alicyclic amino acids (ACPC and ACHC). Radioligand binding assay indicated that several of the novel analogs exhibit high affinity for both µ-and d-opioid receptors in rat-or mouse-brain membrane preparations. The most promising derivatives—such as Dmt-Pro-Trp/Phe-Phe-NH 2 , Dmt-(1 S ,2 R )-ACPC-Phe-Phe-NH 2 , and Dmt-(1 S ,2 R )-ACHC-Phe-Phe-NH 2 )—were characterized in recombinant cell lines expressing human µ-or d-opioid receptors. Interestingly, while these novel peptides were potent opioid agonists in the functional [ 35 S]GTPgammaS binding assays in Chinese hamster ovary cells expressing the µ-opioid receptors, some behaved as antagonist or inverse agonist in the human d-opioid receptor-expressing CHO cells. Since it has previously been demonstrated that the coadministration of d-antagonists with µ-analgesics attenuates the development of analgesic tolerance, introduction of high-affinity d-antagonist properties into the µ-agonist endomorphins is expected to lead to potent analgesics that produce limited tolerance.
Indocyanine Green Angiography (1996)

During thelast several years, the potential benefits of indocyanine green (ICG) angiography for imaging choroidal neovascularization (CNV) have been discussed in many publications<sup>1-17</sup>and at scientific meetings<sup>18,19</sup>that have focused on agerelated macular degeneration. Some ophthalmologists specifically refer patients to a center for performance and interpretation of ICG angiography for a variety of macular disorders. A few of our patients scan the medical literature and then ask whether their macular abnormalities will be imaged with ICG. Ophthalmologists who train at our institution ask for guidance on what they should learn about ICG angiography. Many physicians around the world have asked us whether ICG angiography can help preserve the vision of our patients. <h3>DATA SUGGESTING BENEFITS OF ICG</h3> Do we have data to suggest that ICG angiographic images may provide clinically significant advantages to preserve the vision of our patients? The most promising data available have been obtained
Internal Short Circuit Fault Diagnosis for Lithiumion Battery Based on Voltage and Temperature (2019)

The internal short circuit is one of the main causes of fire and explosion of electric vehicle power battery. It is of great importance to detect the internal short circuit fault of lithium battery early for the safe operation of electric vehicles. This paper presents an internal short circuit fault diagnosis method based on the voltage and temperature. The method uses directly measured cell voltages and temperatures without the need of additional hardware. The fault diagnosis of the internal short circuit is realized by analyzing the difference of the voltages and temperatures between the fault battery and the normal battery. In the experiment, three resistors with different resistance values are connected to the battery in parallel to simulate different levels of failure. Experimental results show that this method can effectively diagnose the internal short circuit of the battery.
CCL2 as a trigger of manifestations of compensatory anti-inflammatory response syndrome in mice with severe systemic inflammatory response syndrome (2006)

Patients with compensatory anti-inflammatory response syndrome (CARS) are at a higher risk for infection with various opportunistic pathogens. CARS develops commonly in association with the manifestation of systemic inflammatory response syndrome (SIRS). In the present study, the role of SIRS-associated soluble factors on the CARS development was examined in mice with pancreatitis, a carrier of typical SIRS. Following the production of SIRS-related cytokines [tumor necrosis factor alpha and interleukin (IL)-1beta], CC chemokine ligand 2 (CCL2), IL-4, and IL-10 (typical CARS cytokines) were detected in the sera of mice with pancreatitis. CCL2 has been described as an essential chemokine for the T helper cell type 2 manifestation. CARS effector cells (cells with an ability to produce IL-4 and IL-10) were not generated from normal T cells after stimulation with SIRS-related cytokines. However, these cells were generated from normal T cells after cultivation with peripheral blood neutrophils (PMN) from SIRS mice in a dual-chamber transwell. Normal T cells did not convert to CARS effector cells after transwell cultures with PMN from normal mice. CCL2 was detected in culture fluids of PMN from SIRS mice, and PMN from normal mice did not produce CCL2 into their culture fluids. CARS effector cells did not appear in PMN-depleted SIRS mice or SIRS mice treated with anti-CCL2 monoclonal antibody, and these cells were demonstrated in PMN-depleted SIRS mice after treatment with recombinant murine CCL2. These results indicate that CCL2 produced by PMN from SIRS mice is an active molecule on the SIRS-associated CARS manifestation.
Specific RNAi Mediated Gene Knockdown in Zebrafish Cell Lines (2005)

Here we demonstrate highly efficient RNA interference in ZFL, SJD and ZF4 cell lines derived from adult and embryonic zebrafish Danio rerio. Microinjection of siRNAs resulted in silencing in almost 100% of cells while transfection using cationic liposomes led to silencing in 30%. Use of siRNAs against zebrafish lamin A, lamin B2 and the motor protein Eg5, led to knockdown of the target genes with the specific phenotypes expected from prior studies in mammalian cells. In contrast injection of lamin A, GL2 and eGFP siRNAs into zebrafish embryos resulted in morphological defects, abnormal development and early death of most embryos. The results indicate unspecific responses to siRNAs in the embryo but a fully developed and active RNAi machinery in cell lines.
All-optical cascadable NOR gate with gain (1990)

An ultrafast, all-optical, three-terminal NOR gate based on soliton dragging in fibers is demonstrated with a gain of 4.5 and a switching energy of 30 pJ. Cascadability is proved with a tandem of two NOR gates that are configured as inverters. Time shifts from soliton dragging between two orthogonally polarized pulses in a fiber can be used for logic operations in a clocked system. Larger-than-predicted time shifts are observed because of self- and cross-Raman amplification effects.