gebhart/patrepeval huggingface dataset:
Photobiomodulation Reduces the Cytokine Storm Syndrome Associated with COVID-19 in the Zebrafish Model (2023)

Although the exact mechanism of the pathogenesis of coronavirus SARS-CoV-2 (COVID-19) is not fully understood, oxidative stress and the release of pro-inflammatory cytokines have been highlighted as playing a vital role in the pathogenesis of the disease. In this sense, alternative treatments are needed to reduce the level of inflammation caused by COVID-19. Therefore, this study aimed to investigate the potential effect of red photobiomodulation (PBM) as an attractive therapy to downregulate the cytokine storm caused by COVID-19 in a zebrafish model. RT-qPCR analyses and protein-protein interaction prediction among SARS-CoV-2 and <i>Danio rerio</i> proteins showed that recombinant Spike protein (rSpike) was responsible for generating systemic inflammatory processes with significantly increased levels of pro-inflammatory (<i>il1b</i>, <i>il6</i>, <i>tnfa</i>, and <i>nfkbiab</i>), oxidative stress (<i>romo1</i>) and energy metabolism (<i>slc2a1a and coa1</i>) mRNA markers, with a pattern similar to those observed in COVID-19 cases in humans. On the other hand, PBM treatment was able to decrease the mRNA levels of these pro-inflammatory and oxidative stress markers compared with rSpike in various tissues, promoting an anti-inflammatory response. Conversely, PBM promotes cellular and tissue repair of injured tissues and significantly increases the survival rate of rSpike-inoculated individuals. Additionally, metabolomics analysis showed that the most-impacted metabolic pathways between PBM and the rSpike treated groups were related to steroid metabolism, immune system, and lipid metabolism. Together, our findings suggest that the inflammatory process is an incisive feature of COVID-19 and red PBM can be used as a novel therapeutic agent for COVID-19 by regulating the inflammatory response. Nevertheless, the need for more clinical trials remains, and there is a significant gap to overcome before clinical trials can commence.
ChemInform Abstract: STUDIES ON KETENE AND ITS DERIVATIVES PART 64, REACTION OF DIKETENE WITH ACRIDINE N‐OXIDE (1974)

Abstract Acridin‐N‐Oxid (I) reagiert mit Diketen (II) über diskutierte Zwischenstufen zum 9‐Acetonyl‐acridin (III), das unabhängig aus Acridin (V) durch Reaktion mit Aceton/ Methylat zu (IV) und dessen Oxidation mit Chloranil entsteht.
Catalysis by Brönsted bases of the reaction between CO2and water (1963)

M. M. Sharma and P. V. Danckwerts, Trans. Faraday Soc., 1963, 59, 386 DOI: 10.1039/TF9635900386
A Convenient N-Arylation Route for Electron-Deficient Pyridines: The Case of π-Extended Electrochromic Phosphaviologens (2015)

A simple and representative procedure for the synthesis of N,N'-diarylated phosphaviologens directly from both electron-rich and electron-poor diaryliodonium salts and 2,7-diazadibenzophosphole oxide is reported. The latter are electron-deficient congeners of the widely utilized N,N'-disubstituted 4,4'-bipyridinium cations, also known as viologens, that proved to be inaccessible by the classical two-step route. The single-step preparation method for phosphaviologens described herein could be extended to genuine viologens but reached its limit when sterically demanding diaryliodonium salts were used. The studied phosphaviologens feature a significantly lowered reduction threshold as compared to all other (phospha)viologens known to date due to the combination of an extended π-system with an electron deficient phosphole core. In addition, a considerably smaller HOMO-LUMO gap was observed due to efficient π-delocalization across the phosphaviologen core, as well as the N-aryl substituents, which was corroborated by quantum chemical calculations. Detailed characterizations of the singly reduced radical species by EPR spectroscopy and DFT calculations verified delocalization of the radical over the extended π-system. Finally, to gain deeper insight into the suitability of the new compounds as electroactive and electrochromic materials, multicolored proof-of-concept electrochomic devices were manufactured.
LLC resonant converter for front end DC/DC conversion (2003)

A new LLC resonant converter is proposed for front end DC/DC conversion in a distributed power system. Three advantages are achieved with this resonant converter. First, ZVS turn on and low turn off current of MOSFETs are achieved. The switching loss is reduced so we can operate the converter at higher switching frequency. The second advantage is that with this topology, we can optimize the converter at high input voltage. Finally, with this topology, we can eliminate the secondary filter inductor, so the voltage stress on the secondary rectifier will be limited to two times the output voltage, better rectifier diodes can be used and secondary conduction loss can be reduced. The converter utilizes leakage and magnetizing inductance of a transformer. With magnetic integration concept, all the magnetic components can be built in one magnetic core. The operation and characteristic of this converter is introduced and efficiency comparison between this converter and a conventional PWM converter is given which shows a great improvement by using this topology.
Clinical Significance of Urinary C‐Peptide Excretion in Children with Insulin‐Dependent Diabetes Mellitus (1989)

In order to evaluate the accuracy of urinary C-peptide determination and the clinical significance of C-peptiduria for the early course of insulin-dependent diabetes (IDDM), the rate of urinary excretion of C-peptide was determined in 32 children and adolescents with IDDM and correlated with serum C-peptide concentration, urinary excretion of albumin and beta 2-microgloublin and with the glomerular filtration rate (GFR) measured in terms of the clearance of 99mTc-DTPA. The age of the subjects ranged from 9.1 to 17.1 years (mean 13.1) and the duration of diabetes from 0.3 to 11.9 years (mean 4.6). There was a good correlation between postprandial serum C-peptide concentration and the 24-hour urinary C-peptide excretion rate (r = 0.81; p less than 0.001). GFR and urinary albumin excretion were slightly elevated in the diabetic patients as compared with non-diabetic subjects (p less than 0.05 and p less than 0.001, respectively), but C-peptide excretion was unrelated to the degree of hyperfiltration or albuminuria, neither was there any correlation between the excretion rate of beta 2-microglobulin and C-peptide. Glycaemic control was poorer in the diabetic children who had only trace amounts of C-peptide in their urine (less than 0.05 nmol/m2/24 h) than in those with minimal (0.05-1.0 nmol/m2) or moderate 24-hour urinary C-peptide excretion (greater than 1.0 nmol/m2). It is concluded that urinary C-peptide excretion serves very well to reflect residual beta-cell function and is unrelated to the slight renal hyperfunction and albuminuria often seen in diabetic subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
Coexistent trigeminal neuralgia, hemifacial spasm, and hypertension: preoperative imaging of neurovascular compression (1994)

The case is reported of a 60-year-old woman with left-sided trigeminal neuralgia, hemifacial spasm, and hypertension. Compression of the left trigeminal, facial, and vagus nerves by the anterior and posterior inferior cerebellar arteries and a persistent trigeminal artery variant were demonstrated by magnetic resonance angiography using a novel sequence. At operation the angiographic appearances were confirmed, and decompression was performed with the placement of polyvinyl sponge at all three levels. Postoperatively, the patient had complete relief from the trigeminal neuralgia and hemifacial spasm and has sustained normotension without medication.
Integration of T2* mapping in daily prostate MR-Linac workflow for hypoxia characterisation (2023)

T 2 * mapping can be a potential biomarker to characterise hypoxia and monitor treatment response throughout the course of MR-guided radiotherapy on an MR-Linac. This study explores the feasibility of integrating T 2 * mapping in daily prostate MR-Linac workflow using a cohort of patients with prostate cancer. We compared mean T 2 * values within the prostate with repeated measures acquired twice weekly during radiotherapy. T 2 * values at the end of treatment were higher than at the first fraction but didn&amp;rsquo;t show a consistent trend throughout treatment. Integrating T 2 * mapping with other functional measurements can aid in response based treatment adaptation.
Syntheses and characterization of physically crosslinked hydrogels from dithiocarbamate‐derived polyurethane macroiniferter (2008)

Abstract A dithiocarbamate (DC)‐based polyurethane macroiniferter (PUMI) was synthesized and used to prepare physically crosslinked polyurethane‐ block ‐poly (acrylamide) (PU‐ b ‐PAAm) and polyurethane‐ block ‐poly(vinyl pyrrolidone) (PU‐ b ‐PVP) hydrogels. The success of the reactions has been confirmed by FTIR, 1 H‐NMR, and 13 C‐NMR Spectroscopy analyses. The number average molecular weight of the block copolymers increased linearly with conversion and copolymerization time and thus followed a “living” radical mechanism. The water transport behavior of these polyurethane‐based hydrogels such as water uptake rate, equilibrium water content (EWC), transport number ( n ), characteristic diffusion rate constant ( K ), diffusion coefficient ( D ), and pH effect on EWC has been investigated. The results revealed that PU‐ b ‐PAAm hydrogels followed Fickian diffusion suggesting diffusion controlled swelling kinetics, whereas the PU‐ b ‐PVP hydrogels followed non‐Fickian diffusion indicating that both diffusion and structural relaxation controlled the water transport. The PU‐ b ‐PAAm hydrogels showed higher swelling at both low and high pH than at a neutral pH. This is attributed to protonation of the tertiary amines of N,N ′‐diethyl‐ N,N ′‐bis(2‐hydroxyethyl) thiuram disulfide (DHTD) at low pH and base hydrolysis of amide segments at high pH. In the thermogravimetric analysis; PUMI, PU‐ b ‐PVP and PU‐ b ‐PAAm have degraded in three distinct stages related to CS 2 evolution, hard segment degradation, and soft segment degradation. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 6272–6284, 2008
An experimental testbed for intelligent control (2005)

In this paper we discuss the development of an experimental testbed for research in intelligent robotic systems. Our system, an air hockey playing robot, consists of a direct drive robot arm, DSP controller, DataCube vision system, CCD camera and air table, is an excellent vehicle to facilitate our research in the integration of machine learning with nonlinear and adaptive control theory and real-time visual servoing. As a first application we present a new result on adaptive visual servoing with online calibration for this system.
Neutron detection experiments with ionization counter and /sup 6/Li converter (2004)

The detection of neutrons with thin /sup 6/Li containing films or layers within an ionization chamber is discussed. A detection efficiency of 50% for thermal neutrons is obtainable with three 100-/spl mu/m thin /sup 6/Li foils. Preliminary measurements were performed with converters which contain a 1-/spl mu/m thin /sup 6/LiF layer. The detector efficiency is only 3%. Pulse height distributions were measured and analyzed for the gases Ar, CF/sub 4/, and C/sub 2/F/sub 6/ at pressures between 0.5 and 5 atm and at voltages between 50 and 500 V. Diffraction peaks from polycrystalline iron and semi-crystalline pyrolytic graphite were measured in TOF mode and are presented.
Analysis of mechanical structures using plate finite element method under different boundary conditions (2018)

The mechanical discrete or continuum structures are actually of great importance in the application field of contemporary modern industry. However, during their life time these structures are often subjected to considerable external stresses or to high amplitudes of vibrations which can cause them large deformations and internal stresses which can cause them internal cracking or even their total destruction. In order to avoid these types of problems, the concept of static and dynamic analysis of these structures is recommended, and due to the complexity of their shape and size, the finite element method is the most used. The latter is currently recognized as a very powerful technique for the static and dynamic analysis of discrete or continuous structures of complicated form applied in the field of mechanics, aeronautics, civil engineering, maritime or robotics. Consequently, the calculation and dimensioning of these mechanical systems by the finite element method plays an important role at the service of the industry for possible sizing and prediction of their lifetime. Our work consists of static and dynamic analysis of two-dimensional discrete and continuous mechanical systems using the finite element method based on the main elements of bars, beams and plates, under the effect of external excitations with different boundary conditions. The discrete structures considered are two-dimensional in metallic framework interconnected to the nodes by welding, riveting or bolted under various boundary conditions. Their elements are modeled comparatively by bar elements and beam elements, while for continuous structures the elements are rectangular thin plates with different boundary conditions. The excitation forces are based on periodic, random or impulsive forces and a numerical solution by development of a program to describe the behavior of these structures is realized. The mass and stiffness matrices of all the structures are determined respectively by assembling the bars, beam and plate elements based on the kinetic and deformation energy for each element. The displacements, the node reactions and the axial forces in all the elements as well as the transverse stresses and the eigenvalues of the structures under different boundary conditions were also calculated and good results were obtained compared to those obtained using other software already existing. In fact, analysis using the finite element method will allow the proper dimensioning and design of complex industrial mechanical structures according to different boundary conditions, their internal loading and their vibratory level.
Critical Materiality (2019)

The miniaturization of electronic technologies, as well as advances in organic and material science, have contributed to the development of composite, smart, and computational materials that create promising narratives for the future of ubiquitous computing. The goal of this one-day studio is to develop tools to acquire a deeper conceptual and critical understanding of materiality in HCI. The studio will draw on strategies from a broad range of sources including critical making, speculative design, experiential prototyping, and indigenous ontologies, in order to map out key questions and concerns. The studio will give the participants the opportunity to discuss the concept of Critical Materiality as a framework for developing tangible, embedded, and embodied interfaces, by brainstorming narratives around the past lives, current uses, and the future imaginaries of materials. Participants will co-develop a shared vocabulary and theoretical framework for Critical Materiality as a strategy to be deployed in conceiving and implementing HCI artifacts and experiences. The studio will culminate in the design and production of a deck of cards that propose keywords, questions, concerns, and opportunities for Hybrid Materials within this Critical Materiality framework. The deck of cards will be made available during the conference and distributed online.
Heterogeneous Multi-core Architectures (2015)

Transistor count continues to increase for silicon devices following Moore's Law. But the failure of Dennard scaling has brought the computing community to a crossroad where power has become the major limiting factor. Thus future chips can have many cores; but only a fraction of them can be switched on at any point in time. This dark silicon era, where significant fraction of the chip real estate remains dark, has necessitated a fundamental rethinking in architectural designs. In this context, heterogeneous multi-core architectures combining functionality and performance-wise divergent mix of processing cores (CPU, GPU, special-purpose accelerators, and reconfigurable computing) offer a promising option. Heterogeneous multi-cores can potentially provide energy-efficient computation as only the cores most suitable for the current computation need to be switched on. This article presents an overview of the state-of-the-art in heterogeneous multi-core landscape.
Deescription lookup based UPnP extension for wireless sensor networks (2009)

Established service discovery protocols such as UPnP allow control points to find devices and services and to retrieve descriptions about them in order to learn all about the device and services. However, general device-control point approaches are not suitable for wireless sensor networks due to se
Lactoferrin Inhibits Hepatitis C Virus Viremia in Patients with Chronic Hepatitis C: A Pilot Study (1999)

Hepatitis C virus (HCV) is associated with the development of cirrhosis and hepatocellular carcinoma. We recently found that bovine lactoferrin, a milk protein belonging to the iron transporter family, effectively prevented HCV infection in cultured human hepatocytes (PH5CH8). We tested the hypothesis that lactoferrin inhibits HCV viremia in patients with chronic hepatitis C. Eleven patients with chronic hepatitis C received an 8-week course of bovine lactoferrin (1.8 or 3.6 g/day). At the end of lactoferrin treatment, a decrease in serum alanine transaminase and HCV RNA concentrations was apparent in 3 (75%) of 4 patients with low pretreatment serum concentrations of HCV RNA. However, 7 patients with high pretreatment concentrations showed no significant changes in these indices. This pilot study suggests that lactoferrin is one potential candidate as an anti-HCV reagent that may be effective for the treatment of patients with chronic hepatitis.
Peer-to-peer Collaborative Vehicle Health Management – the Concept and an Initial Study (2012)

Advanced vehicle diagnostics and prognostics (D&amp;P) technology enhances ownership experience and reduces corporate warranty cost. D&amp;P performance optimization requires significant algorithm tuning and a large amount of test data collection, which is resource consuming. In this paper, we propose a novel D&amp;P framework called Collaborative Vehicle Health Management (CVHM) to automatically optimize the D&amp;P algorithms on a host vehicle, using the field data collected from peer vehicles encountered on the road. The carefully designed system architecture and learning algorithms enhance D&amp;P performance without costly human intervention. The experimental results on battery remaining useful life prediction show the effectiveness of the proposed framework. This proposed framework has been implemented in a small test fleet as a proof-of-concept prototype.
A spot-check of the efficacies of albendazole or levamisole, against soil-transmitted helminthiases in young Ungujan children, reveals low frequencies of cure (2009)

(2009). A spot-check of the efficacies of albendazole or levamisole, against soil-transmitted helminthiases in young Ungujan children, reveals low frequencies of cure. Annals of Tropical Medicine & Parasitology: Vol. 103, No. 4, pp. 357-360.
Bronchiolitis Obliterans Syndrome and Chronic Lung Allograft Dysfunction: Evolving Concepts and Nomenclature (2013)

Bronchiolitis obliterans syndrome (BOS) eventually occurs in the majority of lung transplant recipients who survive beyond 1 year, can greatly impair quality of life, and is, directly or indirectly, the major cause of delayed allograft dysfunction and recipient death. A number of associated events or conditions are strongly associated with the risk for developing BOS; these include acute rejection, gastroesophageal reflux, infections, and autoimmune reactions that can occur in the setting of alloimmune responses to the lung allograft as recipients are given intense immunosuppression to prevent allograft rejection. The term chronic lung allograft dysfunction (CLAD) is being increasingly used to refer to recipients with late allograft dysfunction that meets the spirometric criteria for the diagnosis of BOS, but clinicians should recognize that such dysfunction can occur for a variety of reasons other than BOS. The recently identified entity of restrictive allograft syndrome, which is now recognized as a relatively distinct phenotype of CLAD, has features that differentiate it from classic obstructive BOS. A number of other entities that can also significantly affect allograft function must also be considered when significant allograft dysfunction is encountered following lung transplantation.
Waste to energy: effect of reaction parameters on the transesterification of animal fat oil to biodiesel over a solid hydroxy sodalite catalyst (2018)

In this study, SOD crystals, synthesised via a hydrothermal synthesis method, were used as solid catalyst to convert beef tallow oil (BTO) into biodiesel. Transesterification reaction was conducted at methanol-to-oil ratio of 7.5 : 1 using 3 wt. % SOD catalyst. Reaction conditions were varied as: mixing intensity (700-1250 rpm); catalyst particle size (200-300 Å); reaction time (6-24 h); and reaction temperature (40-60°C). The physicochemical characterisation of the SOD catalyst was conducted using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), N2 physisorption at 77 K (for textural property) and thermogravimetric analysis (for thermal stability). The FFA content of the BTO was 4.53%. Physicochemical characterisation shows that SOD crystals were synthesised. The reaction products analysed with a pre-calibrated gas chromatography-mass spectrometer (GC-MS) confirmed the influence of reaction process parameters on the yield of biodiesel leading to a highest FAME (fatty acid methyl ester) yield of 78.3% at agitation speed of 1000 rpm and catalyst particle size of 200 Å. The reaction temperature and reaction time at this condition were 60°C and 24 h, respectively.
Initial testing of the multitargeted kinase inhibitor pazopanib by the pediatric preclinical testing program (2011)

Pazopanib is an oral angiogenesis inhibitor targeting vascular growth factor receptor-1, -2, and -3, platelet derived growth factor receptor-α, platelet derived growth factor receptor-β, and KIT that has demonstrated activity against a variety of adult cancer xenografts. Pazopanib was tested against a panel of pediatric rhabdomyosarcoma and Ewing sarcoma xenografts at a dose of 108 mg/kg/day or 100 mg/kg twice daily, administered orally for 28 days. While no objective responses were observed, pazopanib induced statistically significant differences in event-free survival compared to controls in approximately one-half of the sarcoma xenograft models tested. Though well tolerated, pazopanib showed limited activity against the sarcoma models evaluated, with the best tumor responses being growth delay.