gebhart/patrepeval huggingface dataset:
Reliability evaluation of a MEMS scanner (2017)

Previously, the realization and closed loop control of a MEMS scanner integrating position sensors made with piezoresistive sensors was presented. It consisted of a silicon compliant membrane with integrated position sensors, on which a mirror and a magnet were assembled. This device was mounted on a PCB containing coils for electromagnetic actuation. In this work, the reliability of such system was evaluated through thermal and mechanical analysis. The objective of thermal analysis was to evaluate the lifetime of the MEMS scanner and is consisting of temperature cycling (-40°C to 100°C) and accelerated electrical endurance (100°C with power supplied to all electrical components). The objective of mechanical analysis was to assess the resistance of the system to mechanical stress and is consisting of mechanical shock and vibration. A high speed camera has been used to observe the behavior of the MEMS scanner. The use of shock stopper to improve the mechanical resistance has been evaluated and had demonstrated a resistance increase from 250g to 900g. The minimum shock resistance required for the system is 500g for transportation and 1000g for portative devices.
Antioxidants in food and chronic degenerative diseases. (1996)

Both preventive and chain breaking antioxidants have a role in the limitation of free radical damage. Some of these may be regarded as "classical", like vitamins E and C but others are more recently discovered, such as the flavonoids, widespread in plant tissues, and the muscle constituents anserine and carnosine. The major conditions in which the role of antioxidants is under intense investigation include coronary artery disease, cancer and diabetes. There are theoretical underpinnings for the efficacy of antioxidants in each of these, with the protection of low density lipoprotein (in respect of the first) being exceptionally persuasive. Much attention is now being focussed on the flavonoids, which are surprisingly pleiotropic in their effects. For one of them, quercetin, over a dozen seemingly independent biological effects can be listed, including the inhibition of low density lipoprotein oxidation. Flavonoids also inhibit peroxidation in foodstuffs, as opposed to tissues. There is much controversy over antioxidant supplementation policies, some authorities recommending a massive programme of supplementation for all ages and classes, others stressing the value of the traditional mixed diet. This matter is unlikely to be resolved soon, but in the meantime sensible supplementation policies should be continued for those most vulnerable, that is, babies and the aged.
Model-based fusion of CT and non-contrasted 3D C-arm CT: Application to transcatheter valve therapies (2012)

In recent years transcatheter valve therapies are beginning to replace invasive surgical procedures. As there is no direct view and access to the affected anatomy advanced imaging techniques such as 3D rotational angiography (C-arm CT) and real-time fluoroscopy are used for intra-operative guidance. However, intra-operative modalities have limited image quality of the soft tissue and a reliable assessment of the cardiac anatomy can only be made by injecting contrast agent, which is harmful to the patient and requires complex acquisition protocols. We propose a novel method to align pre-operative and intra-operative data by using surrogate anatomical structures which are visible in both modalities without adding contrast agent. The trachea bifurcation model is used as a surrogate structure and the model parameters are estimated using robust machine learning algorithms. High quality patient specific models can be extracted from the pre-operative CT and mapped to the intra-operative 3D C-arm CT for guidance. In addition we learn a weighted mapping function for the trachea bifurcation model extracted from the pre-operative and intra-operative images which minimizes the mapping error in respect to the anatomy of interest. Experiments performed on 28 patient pairs of CT and contrasted 3D C-arm CT data sets assure an accuracy of the mapped aortic valve model of 9.08 ± 7.31 deg and 7.57 ± 3.22mm.
Sputter Epitaxy of Ag and Ni Films (1982)

Epitaxial films of silver are grown by sputtering on mica substrates at elevated temperature. A systematic study of samples grown on different substrates and at different temperatures is carried out using X-ray diffraction (θ–2θ and Laue). Both the temperature and substrate play crucial roles for the growth of epitaxial films. The growth of epitaxial Ni on Ag single crystal by sputtering is also reported. Epitaktische Schichten von Silber auf einer Glimmerunterlage werden mit der Sputtertechnik bei erhöhten Temperaturen hergestellt. Proben, gezogen bei verschiedenen Temperaturen und auf verschiedenen Substraten, werden systematisch mit Röntgenstreuung (θ–2θ und Laue) untersucht. Sowohl Temperatur wie Substrat sind entscheidend beim epitaktischen Wachstum der Schichten. Im weiteren wird über durch Sputtern gewonnene epitaktische Ni-Schichten auf Ag-Einkristallen berichtet.
Myth of the Great Trading Nation (2006)

The world's leading competitiveness survey states that, even though Australia's economic management is good, there is a need to improve trade performance.
View-invariant Fall Detection for Elderly in Real Home Environment (2010)

We propose a novel context based human fall detection mechanism in real home environment. Fall incidents are detected using head and floor information. The centroid location of the head and feet from each frame are used to learn a context model consisting of normal head and floor blocks. Every floor block has its associated Gaussian distribution, representing a set of head blocks. This Gaussian distribution defines standard vertical distance as average height of an object at that specific floor block. The classification of blocks and average height is later used to detect a fall. Fall detection methods often detect bending situations as fall. This method is able to distinguish bending and sitting from falling. Furthermore, a fall into any direction and at any distance from camera can be detected. Evaluation results show the robustness and high accuracy of the proposed approach.
A flexible tool suite for change-aware test-driven development of web applications (2010)

Though Web Applications development fits well with Test-Driven Development, there are some problems that hinder its success. In this demo we present a tool suite to improve TDD; the suite supports the representation of web requirements using a domain-specific language and the automatic generation of interaction tests among others.
NVP-AEW541: A Selective Small Molecule IGF-1R Tyrosine Kinase Inhibitor Is Active Against Multiple Myeloma and Other Hematologic Neoplasias and Solid Tumors. (2004)

Abstract We have shown that insulin-like growth factors (IGFs) and their receptor IGF-1R play critical roles in proliferation, survival and drug-resistance of a broad spectrum of hematologic malignancies and solid tumors and that selective inhibitors of IGF-1R kinase activity have in vivo anti-tumor activity in clinically relevant orthotopic tumor models (Cancer Cell2004;5:221–30). We now describe the in vitro and in vivo activity of NVP-AEW541, a novel pyrrolo[2,3-d] pyrimidine selective IGF-1R tyrosine kinase inhibitor with 27-fold selectivity for IGF-1R vs. its highly homologous insulin receptor. NVP-AEW541 is active (at sub-uM levels) against diverse tumor types, including &gt;30 MM cell lines and &gt;10 primary tumor cells from MM patients (including cells resistant to Dex, alkylating agents, anthracyclines, thalidomide, or its immunomodulatory derivatives, IMiDs, bortezomib, and/or Apo2L/TRAIL); and cell lines from diverse hematologic malignancies (including B- and T-ALL, AML, CML, and lymphoma subtypes) and solid tumors (e.g. breast, prostate, lung, thyroid, ovarian, renal Ca, retinoblastoma and sarcomas). All studied tumor cells expressed IGF-1R, without any correlation between mean fluorescence intensity of expression of IGF-1R (or its decoy non-signaling counterpart IGF-2R/CD222) and the degree of tumor cell sensitivity to NVP-AEW541. The in vitro anti-tumor effects of NVP-AEW541 were highly consistent with those of other selective anti-IGF-1R neutralizing agents, including another IGF-IR inhibitor of the pyrrolo[2,3-d] pyrimidine structural class (NVP-ADW742) or anti-human IGF-1R-specific neutralizing mAb’s (aIR3). NVP-AEW541 counteracts the proliferative/anti-apoptotic effect of serum on tumor cells from the entire spectrum of diseases that were studied, but more prominently against MM cells. Importantly, NVP-AEW541 had in vivo anti-tumor activity in a SCID/NOD mice model of diffuse MM. Mechanistically, IGF-1R inhibition by NVP-AEW541 blocks key growth/survival pathways (e.g. PI-3K/Akt, Ras/Raf/MAPK, IKK-a/NF-kB); blocks expression of inhibitors of apoptosis (e.g. FLIP, cIAP-2, survivin); and suppresses both constitutive and serum- or IGF-1-induced upregulation of proteasome activity. These molecular sequelae can explain why NVP-AEW541 sensitized tumor cells (e.g. MM, PrCa, BrCa or sarcomas) to other anti-cancer drugs (e.g. Dex, cytotoxic chemotherapeutics and PS-341); blunted tumor cell responses to other growth factors (e.g. MM or PrCa cell response to IL-6); overcame the drug-resistance phenotype conferred by bone marrow stromal cells; and abrogated VEGF production in co-cultures of MM cells with BMSCs. These studies further confirm that IGF-1R plays major role in growth/survival of neoplastic cells, indicate that IGF-1R pathway can be targeted with multiple clinically applicable approaches; and provide proof-of-principle for clinical trials of NVP-AEW541, e.g. in MM, a disease particularly dependent upon IGF-1R function.
Average mass approach to the isotopic analyses of compounds exhibiting significant interfering ions (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAverage mass approach to the isotopic analyses of compounds exhibiting significant interfering ionsKarl F. BlomCite this: Anal. Chem. 1988, 60, 10, 966–971Publication Date (Print):May 15, 1988Publication History Published online1 May 2002Published inissue 15 May 1988https://pubs.acs.org/doi/10.1021/ac00161a004https://doi.org/10.1021/ac00161a004research-articleACS PublicationsRequest reuse permissionsArticle Views31Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reversed-Phase HPLC Analysis of Steviol Glycosides Isolated from Stevia rebaudiana Bertoni (2014)

High Performance Liquid Chromatography (HPLC) experiments have been performed on nine steviol glycosides namely rebaudioside A, steviolbioside, stevioside, rubusoside, rebaudioside B, rebaudioside C, rebaudioside D, rebaudioside F, and dulcoside A isolated from the leaves of Stevia rebaudiana using Reversed-Phase (RP) column. Using RP-HPLC method, the individual retention times for nine naturally occurring ent-kaurane diterpene glycosides of S. rebaudiana reported in JECFA have been determined at four different temperatures: 20℃, 40℃, 60℃, and 79℃. Also, calculated the relative retention times of the eight steviol glycosides steviolbioside, stevioside, rubusoside, rebaudioside B, rebaudioside C, rebaudioside D, rebaudioside F, and dulcoside A against the major steviol glycoside rebaudioside A. HPLC results suggested that temperatures 40℃ and 60℃ would be ideal conditions for better separation of steviol glycosides.
CPMV-DOX Delivers (2012)

The plant virus, Cowpea mosaic virus (CPMV), is developed as a carrier of the chemotherapeutic drug doxorubicin (DOX). CPMV-DOX conjugate, in which eighty DOX molecules are covalently bound to external surface carboxylates of the viral nanoparticle (VNP), shows greater cytotoxicity than free DOX toward HeLa cells when administered at low dosage. At higher concentrations, CPMV-DOX cytotoxicity is time-delayed. The CPMV conjugate is targeted to the endolysosomal compartment of the cells, in which the proteinaceous drug carrier is degraded and the drug released. This study is the first demonstrating the utility of CPMV as a drug delivery vehicle.
Direct formation of alcohols in homogeneous hydroformylation catalysed by rhodium complexes (1990)

Hydroformylation of hex-1-ene catalysed by [RhH(PEt3)3] or [Rh2(OAc)4]/PR3, R = Me, Et, or Bu, produces a mixture of aldehydes and alcohols in toluene or tetrahydrofuran but exclusively alcohols in ethanol; [Rh2(OAc)4] or [RhH(CO)(PPh3)3] produce mainly aldehydes or acetals when ethanol is used as the solvent.
Coherent Detection for Fiber Optic Communications Using Digital Signal Processing (2006)

The arrival recently of gigabit rate digital signal processing technology means that coherent detection can once again be considered for optical communications. The key advantages of coherent over direct detection will be presented, together with experimental results.
ChemInform Abstract: Four Decades of Organic Chemistry of closo‐Boranes: A Synthetic Toolbox for Constructing Liquid Crystal Materials (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Immunotherapeutic targeting of HSP90 client proteins overexpressed in chemo-/radio-resistant melanoma (TUM2P.1012) (2015)

Abstract Amongst the numerous genetic alterations that occur in cancer cells, is overexpression of DNA repair proteins (DNA-RP) in a disease-stage associated manner which has also been correlated to chemo/radiotherapy (CRT) resistance and poor overall prognosis. DNA-RP overexpression has been reported to involve post-translational protein stabilization mediated by the molecular chaperone Heat shock protein 90(HSP90), thereby preventing proteasome-dependent degradation of these HSP90 “client” proteins. Hence, HSP90 inhibitors (HSP90i) have been heralded as co-therapy agents for cancer patients that have developed resistance to first-line treatments such as temozolomide (TMZ). Under conditions in which its function is blocked by HSP90i, HSP90 client proteins rapidly become (poly)ubiquinated and undergo degradation resulting in improved sensitization of cancer cells to CRT. We observed that HSP90i promote the proteasome-dependent (i.e. blocked by inhibitors PS-341 and MG-132) degradation of a range of DNA-repair client proteins. We have also identified H-2Kb/Db-presented peptide epitopes derived from these DNA-RPs that may be recognized by Type-1 CD8+ T cells after specific vaccination in C57BL/6 mice. We are currently investigating the capacity of HSP90i to conditionally sensitize melanoma cells to the tumoricidal action of CRT as well as CD8+ T cells reactive against overexpressed DNA-RP that constitute HSP90 client proteins.
Subgroup Discovery in Smart Electricity Meter Data (2014)

This work presents data mining methods for discovering unusual consumption patterns and their associated descriptive models from smart electricity meter data. At present, data mining and knowledge discovery in electricity meter data suffer from three notable weaknesses: 1) insufficient focus on intelligent data analysis of subgroups (subsets) whose patterns vary significantly from aggregate patterns embodied in an entire dataset; 2) a lack of effort towards generating intuitively understandable and practically applicable knowledge for industrial practitioners to identify such subgroups; and 3) limited knowledge regarding the link between unusual consumption patterns and household consumers' socio-demographic characteristics. This paper addresses these practically important but technically challenging issues by applying subgroup discovery algorithms to a real smart electricity meter dataset. Subgroups whose patterns are unusual and whose sizes are large enough are discovered, and their descriptive and predictive models are generated. Furthermore, to enrich subgroup discovery algorithms, three new-quality measures for real-valued targets are proposed. The comparative studies empirically evaluate the effectiveness and usefulness of subgroup discovery on classification accuracy, predictive power, and computational resources. The methodologies and algorithms presented are generic, and therefore applicable to a wider range of data mining problems.
Video over Wireless Zigbee Networks: Multi-Channel Multi-Radio Approach (2008)

The emerging IEEE 802.15.4 (Zigbee) standard is designed for low data rate, low power consumption and low cost wireless personal area networks (WPANs). Video transmission over such networks is considered an issue since video traffic contains a large amount of information that requires high data rates. Wireless standards, including IEEE 802.15.4, in general use a single channel for data transmission even though multiple non-overlapped channels exist in the 2.4 GHz spectrum. The aggregate throughput of these networks can be improved by using multiple channels that are available in the radio spectrum allocated by the standards. The main focus of the paper is on the performance improvement of Zigbee networks under the interference of other 802.15.4 and 802.11 devices using multiple channels and multiple radio interfaces so that video transmission is feasible.
Genetic analysis of the Candida albicans biofilm transcription factor network using simple and complex haploinsufficiency (2017)

Biofilm formation by Candida albicans is a key aspect of its pathobiology and is regulated by an integrated network of transcription factors (Bcr1, Brg1, Efg1, Ndt80, Rob1, and Tec1). To understand the details of how the transcription factors function together to regulate biofilm formation, we used a systematic genetic interaction approach based on generating all possible double heterozygous mutants of the network genes and quantitatively analyzing the genetic interactions between them. Overall, the network is highly susceptible to genetic perturbation with the six network heterozygous mutants all showing alterations in biofilm formation (haploinsufficiency). In addition, many double heterozygous mutants are as severely affected as homozygous deletions. As a result, the network shows properties of a highly interdependent 'small-world' network that is highly efficient but not robust. In addition, these genetic interaction data indicate that TEC1 represents a network component whose expression is highly sensitive to small perturbations in the function of other networks TFs. We have also found that expression of ROB1 is dependent on both auto-regulation and cooperative interactions with other network TFs. Finally, the heterozygous NDT80 deletion mutant is hyperfilamentous under both biofilm and hyphae-inducing conditions in a TEC1-dependent manner. Taken together, genetic interaction analysis of this network has provided new insights into the functions of individual TFs as well as into the role of the overall network topology in its function.
Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells (2023)

The combination of entinostat and PLK1i showed synergistic interaction in vitro, but not in vivo. Therefore, further screening of blood-brain barrier penetrating PLK1i is warranted to determine the true potential of the combination as no on-target activity was observed after PLK1i volasertib treatment in vivo.
Modeling of MOS-Side Carrier Injection in Trench-Gate IGBTs (2010)

A compact trench-gate insulated-gate bipolar transistor model that captures MOS-side carrier injection is developed. The model retains the simplicity of a 1-D solution to the ambipolar diffusion equation, but at the same time, captures the MOS-side carrier injection and its effects on steady-state carrier distribution in the drift region and on switching waveforms.
Design of Compact Size Excitation Device for Antenna Pattern Using Fractal Architectures (2006)

This paper presents the design and the implementation of a device which can properly feeds an antenna composed of three simple radiating elements operating at 2.45 GHz. The designed antenna is of planar type, compact and quite isotropic. Compact size means that the excitation device has to be as small as possible in order to be integrated on the same substrate as the radiating elements. On the hand the excitation device must not affects significantly the radiation pattern. There are several ways to obtain a phase shift of 90/spl deg/ or 180/spl deg/: by using couplers or by splitting the signal into two parts and adjusting the length of the microstrip lines. It is clear however that both these solutions would require a lot of space and an oversized ground plane. For this reason, we decided to design a device using fractal architectures. Its main advantage is that it does not affect the radiation pattern too much and respects the size specifications. A complete antenna has been realized on epoxy substrate. Experimental results confirm the theoretical prediction. In addition, this principle could be used to create even smaller devices by using higher permittivity substrates such as alumina.
Changes in Exercise Patterns in Menopausal Women at Low–Intermediate Risk for Cardiovascular Disease: A Prospective Survey Study (2016)

These data suggest that women can increase their level of physical activity regardless of BMI and that overweight or obese status is not a barrier to initiating an aerobic, nonaerobic, or strength training exercise routine.
Modeling and simulation of the thermomechanical austenitic steel behavior with TWIP effect (TWinning Induced Plasticity) (2006)

International audience
Testicular Microlithiasis in the Setting of Primary Extragonadal Germ Cell Tumor (2016)

The clinical significance of testicular microlithiasis (TM) in patients with primary extragonadal germ cell tumor (EGCT) is not well understood. When EGCT is suspected, sonographic and physical examination of the testicles should be performed to evaluate for testicular lesion or atrophy; negative testicular ultrasound with current technology virtually excludes the possibility of occult primary lesion. Although EGCTs are known to be associated with elevated level of serum tumor markers, the utility of tumor markers in the presence of TM is not well understood. Current guidelines for TM follow-up and management do not include any potential correlation between TM and primary EGCT, an association that should be addressed on future updates.