gebhart/patrepeval huggingface dataset:
Preliminary studies of a novel oral fluoropyrimidine carbamate: capecitabine. (1998)

The suggested phase II dose on a continuous 42-day dosing schedule is 1,331 mg/m2/d. Linear pharmacologic parameters of the parent compound and metabolites are demonstrated.
Molecular and biochemical pharmacology of the histamine H4receptor (2009)

The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H4 receptor by several groups has been instrumental for a new appreciation of the role of histamine in the modulation of immune function. In this review, we summarize the historical developments and the molecular and biochemical pharmacology of the H4 receptor.
Reinforcement of Polylactic Acid for Fused Deposition Modeling Process with Nano Particles Treated Bamboo Powder (2019)

The focus of this report was to understand the tensile properties and dynamic mechanical properties of bamboo powder (BP) reinforced polylactic acid (PLA) composite filaments which were treated with nano calcium carbonate (CaCO<sub>3</sub>), cellulose nanofibers (CNF), and micro-crystalline cellulose (MCC) using impregnation modification technology. The storage modulus (<i>E</i>') of nano CaCO<sub>3</sub>-BP/PLA, MCC-BP/PLA, and CNF-BP/PLA composite filaments increased compared with BP/PLA composite filaments before the glass transition temperature <i>T</i><sub>g</sub>. When the temperature was above <i>T</i><sub>g</sub>, the reinforcement effect of nano CaCO<sub>3</sub>, MCC, and CNF gradually became less apparent. The loss modulus (<i>E</i>'') and loss factor (tan <i>δ</i><sub>max</sub>) of the nano CaCO<sub>3</sub>-BP/PLA, MCC-BP/PLA, and CNF-BP/PLA composite filaments was higher than that of BP/PLA composite filaments produced by the "one-step" method. The tensile strength (TS) results showed a similar trend. Compared with the control samples, the TS of nano CaCO<sub>3</sub>-BP/PLA, MCC-BP/PLA, and CNF-BP/PLA composite filaments produced by the "one-step" method (and the "two-step" method) increased by 40.33% (and 10.10%), 32.35% (and -8.61%), and 12.32% (and -12.85%), respectively. The TS of nano CaCO<sub>3</sub>-BP/PLA, MCC-BP/PLA, and CNF-BP/PLA composite filaments produced by the "one-step" method was slightly higher than those produced by the "two-step" method. The elongation at break (EAB) of BP/PLA composite filaments was higher than that of BP/PLA samples treated with nano CaCO<sub>3</sub>, MCC, or CNF. The PLA and modified BP were readily accessible through a simple mixing process. The rheological investigation of such mixtures showed that nano CaCO<sub>3</sub>, CNF, and MCC have different effects on the processability and rheological properties of composites.
<title>Performance analysis of wind velocity edge techniques utilizing Fabry-Perot etalons</title> (1995)

We developed an analytic framework to asses the performance of wind velocity measurements with the edge technique using a pulsed lidar. This technique is insensitive to frequency jitter and shifts of both laser and filter. This paper analyzes the applicability of the edge technique for a pulsed lidar. We show the velocity estimation with the edge technique is, in general, biased and that the bias depends on signal fading statistics, energy/pulse, and the number of pulses used for estimation. Two practical signal processing algorithms are considered for the wind velocity estimation. Analysis of their performance includes the trade-off between the number of pulses and energy/pulse. The effect of partial coherence of laser radiation is bounded by considering two limiting cases: (1) signal fading and its coherence can be neglected; and (2) signal fading is very strong and the effects of coherence degrade the lidar performance.
Glycosylated Fibronectin as a First-Trimester Biomarker for Prediction of Gestational Diabetes (2013)

In Brief OBJECTIVE: To evaluate the potential clinical utility of serum biomarkers for first-trimester prediction of gestational diabetes mellitus (GDM). METHODS: Maternal serum concentrations of glycosylated (Sambucus nigra lectin–reactive) fibronectin, adiponectin, sex hormone–binding globulin, placental lactogen, and high-sensitivity C-reactive protein (CRP) were measured at 5–13 weeks of gestation in a case-control study of 90 pregnant women with subsequent development of GDM and in 92 control group participants. Ability to detect GDM was assessed using logistic regression modeling and receiver operating characteristic (ROC) curves. Classification performance and positive and negative predictive values were reported at specific thresholds. Glycosylated fibronectin variation across trimesters was evaluated using a serial-measures analysis of 35 nondiabetic control group participants. RESULTS: First-trimester serum concentrations of glycosylated fibronectin, adiponectin, high-sensitivity CRP, and placental lactogen were significantly associated (P<.001) with GDM. After adjustment for maternal factors and other biomarkers, glycosylated fibronectin demonstrated an independent association with GDM (P<.001). Adiponectin, high-sensitivity CRP, and placental lactogen demonstrated modest classification performance compared with glycosylated fibronectin (respectively: area under the curve [AUC] 0.63; 95% confidence interval [CI] 0.53–0.71; AUC 0.68; 95% CI 0.60–0.76; and AUC 0.67, 95% CI 0.59–0.75; compared with AUC 0.91; 95% CI 0.87–0.96). Glycosylated fibronectin levels above a threshold of 120 mg/L correctly identified 57 GDM case group participants with a positive predictive value of 63% (95% CI 53–72%) and a negative predictive value of 95% (95% CI 94–95%) at a population prevalence of 12%. There was no association between sex hormone–binding globulin and GDM. CONCLUSION: First-trimester glycosylated fibronectin is a potential pregnancy-specific biomarker for early identification of women at risk for GDM. LEVEL OF EVIDENCE: II Elevated levels of glycosylated fibronectin in first-trimester maternal serum are associated with subsequent gestational diabetes as determined by oral glucose tolerance test.
Finite element simulation of bulk- and surface acoustic wave (SAW) interaction in SAW devices (2003)

Though loss parameters in SAW propagation are used as input for fast analysis models for the simulation of SAW devices, the quantitatively correct description of loss mechanisms is still a challenging task. Therefore, it is important to develop exact measurement and simulation methods which are able to determine these loss parameters accurately. By the use of special boundary conditions, the finite element method (FEM) is able to fulfill these requirements. Regarding the periodic substructure of common SAW devices, we have incorporated periodic boundary conditions (PBCs) in our simulation code. The piezoelectric substrate of SAW devices operating at high frequencies can be modeled as a semi-infinite half space. Therefore, we introduce newly evolved absorbing boundary conditions. They allow us to examine effects emerging from bulk acoustic wave (BAW) radiation (e.g. bulk wave onset frequencies) and assess propagation loss due to leakage and bulk wave conversion accurately.
Effect of Lubricants on Tensile Strengths of Tablets (1984)

The effect of concentration of lubricant on the axial and radial tensile strengths of tablets was determined for four directly compressible pharmaceutical materials: anhydrous lactose, aspirin, microcrystalline cellulose, and dibasic calcium phosphate dihydrate. The lubricants investigated were: hydrogenated vegetable oil, magnesium stearate, polyethylene glycol 4000, stearic acid, and talc. For plastic materials the tensile strengths were reduced as the concentration of the lubricant was increased. For brittle material the tensile strength was not changed significantly as the concentration of lubricant was increased.
Lateral Flow Assay with Near-Infrared Dye for Multiplex Detection (2013)

NIR-LFAs exhibit quantitative measurement at pg/mL concentrations owing to a high signal-to-background ratio and robust detection antibody clearance through the test strip. Moreover, NIR-LFAs are able to detect molecules present at vastly different concentrations in multiplex format and compare favorably to ELISAs. LFAs with direct NIR detection may be a valuable tool for biomarker evaluation in the point-of-care setting.
Metallographic examination of response of 3 Cr-1. 5 Mo steel to heat treatment (1985)

The influence of austenitizing temperature, cooling rate, and tempering conditions on the microstructure of 3 Cr-1.5 Mo steels was examined in order to establish the heat treatment needed to produce fine-grained bainitic microstructures. Most of the work was performed on samples from an 8-ton commercial heat of a composition developed by the Climax Molybdenum Company that contained a manganese addition for hardenability and a vanadium addition for strength. This material was examined in both the normalized-and-tempered and the quenched-and-tempered conditions. The material was found to be fully bainitic in both the coarse- and fine-grained conditions. Additional studies were performed on another 8-ton commercial heat of a composition developed by the University of California, Berkeley, that contained more nickel and less manganese. This material also possessed adequate hardenability to produce bainitic microstructures for cooling conditions that would result in some proeutectoid ferrite in standard 2.25 Cr-1 Mo steel. Both compositions developed the microstructures and concomitant strength and toughness needed to be competitive with other developing microalloyed steels for use in hydrogen service. 17 refs., 15 figs., 5 tabs.
Comparison of rapid methods for the extraction of bacterial DNA from colonic and caecal lumen contents of the pig (2003)

Results of this study provide a basis for choosing which DNA extraction procedures are most effective for use with samples of pig lumen.
Role of the capsule and the O antigen in resistance of O18:K1 Escherichia coli to complement-mediated killing (1983)

Epidemiological data show that O18:K1 Escherichia coli is a common cause of neonatal bacteremia and meningitis. These bacteria were capable of multiplying in the bloodstream of newborn rats and were resistant to the bactericidal effects of complement in the absence of specific antibodies. The roles played by the O antigen and the K antigen in complement resistance were analyzed by comparing the bactericidal effects of normal sera and of sera deficient in various complement components or in immunoglobulins. These sera were tested on O18:K1 bacteria and on mutants lacking either the lipopolysaccharide O antigen or the K1 capsular polysaccharide. In addition, O1:K1 cells, which can cause pyelonephritis but which are rare in newborn meningitis and which do not multiply in the bloodstream of newborn rats, were also examined. Different mechanisms of protection against the alternative and classical pathways were recognized: K1-positive cells were resistant to the bactericidal activity of sera deficient in classical complement pathway components, whereas K1-negative cells were sensitive to these sera. Based on these results and on those from complement fixation assays, the K1 sialic acid polysaccharide impedes the activation of, and thus protects the bacteria against, the alternative complement pathway. Not only the K1-negative mutant cells but also O1:K1 bacteria and mutants lacking the O18 oligosaccharide repeating units of the lipopolysaccharide were sensitive to the classical complement pathway. These bactericidal effects were observed even in the absence of specific antibodies. It is proposed that both the K1 capsule and the O18 oligosaccharide restrict antibody-independent classical pathway activation by shielding deeper structures on the cell membrane that are capable of activating this pathway.
An On-Line Anomaly Detection Method Based on a New Stationary Metric - Entropy-Ratio (2014)

Anomaly detection has been a hot topic in recent years due to its capability of detecting zero day attacks. In this paper, we propose a new metric called Entropy-Ratio. We validate that the Entropy-Ratio is stationary. Making use of this observation, we combine the Least Mean Square algorithm and the Forward Linear Predictor to propose a new on-line detector called LMS-FLP detector. Using the two synthetic data sets - CEGI-6IX synthetic data and CERNET2 synthetic data, we validate that the LMS-FLP detector is very effective in detecting both anomalies involving many small IP flows and anomalies involving a few large IP flows.
Cholinergic Blockade as Related to Chain Length of Monoquaternary Derivatives of Atropine and Benzoyl-tropine (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCholinergic Blockade as Related to Chain Length of Monoquaternary Derivatives of Atropine and Benzoyl-tropineLester SoykaLester SoykaMore by Lester Soyka and Laszlo GyermekLaszlo GyermekMore by Laszlo GyermekCite this: J. Med. Chem. 1960, 2, 4, 361–373Publication Date (Print):August 1, 1960Publication History Published online1 May 2002Published inissue 1 August 1960https://pubs.acs.org/doi/10.1021/jm50011a002https://doi.org/10.1021/jm50011a002research-articleACS PublicationsRequest reuse permissionsArticle Views77Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Development of a voltage sag detection method for nonutility generation systems (2005)

This paper deals with a new detection method based on three-phase vector operation for voltage sag. The detection method is applicable to a protection system using a high-speed interruption system which protects distributed generators and critical loads in a customer's facility. The algorithm and merits of this method are explained in detail. The detection characteristics are then analyzed using the ATP (Alternative Transients Program) and are confirmed using a real-time digital simulator, and it is shown that the method is useful for detecting voltage sag. © 2005 Wiley Periodicals, Inc. Electr Eng Jpn, 152(4): 34–41, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20117
The treatment of childhood hydrocephalus by choroid plexus coagulation and artificial cerebrospinal fluid perfusion (1990)

The authors report their experience in the treatment of childhood hydrocephalus by endoscopic choroid plexus coagulation and post-operative ventricular perfusion with artificial CSF. The procedure was carried out on 23 children without mortality. In 12 cases (52%) the procedure was successful in controlling the hydrocephalus. The average follow-up was 2.3 years. Eleven cases (48%) required shunting which was done from 1 week to 13 months following the choroid plexus coagulation. As cure of the hydrocephalus was achieved in over half of the patients, the authors recommend the procedure as a first line treatment for childhood hydrocephalus.
Observation of Ds±/D0 Enhancement in Au+Au Collisions at sNN=200  GeV (2021)

We report on the first measurement of charm-strange meson D_{s}^{±} production at midrapidity in Au+Au collisions at sqrt[s_{NN}]=200 GeV from the STAR experiment. The yield ratio between strange (D_{s}^{±}) and nonstrange (D^{0}) open-charm mesons is presented and compared to model calculations. A significant enhancement, relative to a pythia simulation of p+p collisions, is observed in the D_{s}^{±}/D^{0} yield ratio in Au+Au collisions over a large range of collision centralities. Model calculations incorporating abundant strange-quark production in the quark-gluon plasma and coalescence hadronization qualitatively reproduce the data. The transverse-momentum integrated yield ratio of D_{s}^{±}/D^{0} at midrapidity is consistent with a prediction from a statistical hadronization model with the parameters constrained by the yields of light and strange hadrons measured at the same collision energy. These results suggest that the coalescence of charm quarks with strange quarks in the quark-gluon plasma plays an important role in D_{s}^{±}-meson production in heavy-ion collisions.
Development of optical‐driven nanoneedles using SU‐8 nanofabrication (2022)

Abstract We developed an optical‐driven nanoneedle that is operated in aqueous solution by two focused laser beams. A nanoneedle tool consists of 2 μm‐sized structures for optical trapping and a nanoneedle having 200 nm width and 20 μm length. Nanoneedle tools are fabricated with single ultraviolet (UV) lithography of SU‐8 photoresist with highly scalable manner. We evaluated the conditions of the lithography processes: rinse, hard bake and post exposure bake (PEB) that determine the shape of the nanoneedles and recovery rate. We demonstrated the trapping of a nanoneedle tool to verify the manipulation of the position and the orientation. Nanoneedle tools have an advantage in the use of closed microchanells, which can lead to the applications including delivery and extraction of substances inside single cells and pinpoint molecular processing of biomolecules. In this paper, we report on the fabrication process of the nanoneedle tools and the demonstration of the manipulation.
Brief Report: Anti–Tumor Necrosis Factor α Targets Protein Kinase B/c‐Akt–Induced Resistance of Effector Cells to Suppression in Juvenile Idiopathic Arthritis (2013)

This study is the first to show that anti-TNFα targets the resistance of Teff cells to suppression, resulting in improved regulation of inflammatory effector cells.
Ionothermal Synthesis of an Aluminophosphate Molecular Sieve with 20‐Ring Pore Openings (2010)

Aufnahmebereit: Das erste Aluminophosphat-Molekularsieb mit 20-gliedrigen Porenöffnungen wurde durch Ionothermalsynthese in Gegenwart zweier Strukturbildner erhalten (siehe Bild; H weiß, C türkis, N blau). Das Material verfügt über ein viel stabileres -CLO-Gerüst als sein GaPO4-Analogon Cloverit, was Anwendungsmöglichkeiten in Trennverfahren, Katalyse und Gasspeicherung eröffnen könnte. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Neutron Diffraction Study on the Low-Temperature Monoclinic Form of CeCu6 (1986)

The low-temperature form of CeCu 6 has been determined from the Rietveld analysis on high-resolution TOF neutron diffraction data at 65 K. The crystal system is monoclinic with lattice parameters a =0.5080 nm, b =1.0121 nm, c =0.8067 nm and β=91.36°. The space group is P 2 1 / c and the unit cell contains four formula units. The structure is a derivative of the high-temperature orthorhombic form associated with a monoclinic deformation and minor shifts of the atomic positions.
Immunosuppressant Treatment in Rheumatic Musculoskeletal Diseases Does Not Inhibit Elicitation of Humoral Response to SARS-CoV-2 Infection and Preserves Effector Immune Cell Populations (2022)

COVID-19 has proven to be particularly serious and life-threatening for patients presenting with pre-existing pathologies. Patients affected by rheumatic musculoskeletal disease (RMD) are likely to have impaired immune responses against SARS-CoV-2 infection due to their compromised immune system and the prolonged use of disease-modifying anti-rheumatic drugs (DMARDs), which include conventional synthetic (cs) DMARDs or biologic and targeted synthetic (b/ts) DMARDs. To provide an integrated analysis of the immune response following SARS-CoV-2 infection in RMD patients treated with different classes of DMARDs we carried out an immunological analysis of the antibody responses toward SARS-CoV-2 nucleocapsid and RBD proteins and an extensive immunophenotypic analysis of the major immune cell populations. We showed that RMD individuals under most DMARD treatments mount a sustained antibody response to the virus, with neutralizing activity. In addition, they displayed a sizable percentage of effector T and B lymphocytes. Among b-DMARDs, we found that anti-TNFα treatments are more favorable drugs to elicit humoral and cellular immune responses as compared to CTLA4-Ig and anti-IL6R inhibitors. This study provides a whole picture of the humoral and cellular immune responses in RMD patients by reassuring the use of DMARD treatments during COVID-19. The study points to TNF-α inhibitors as those DMARDs permitting elicitation of functional antibodies to SARS-CoV-2 and adaptive effector populations available to counteract possible re-infections.
Active-Passive Dynamic Consensus Filters for Linear Time-Invariant Multiagent Systems (2019)

Active-passive dynamic consensus filters consist of a group of agents, where a subset of these agents are able to observe a quantity of interest (i.e. active agents) and the rest are subject to no observations (i.e. passive agents). Specifically, the objective of these filters is that the states of all agents are required to converge to the weighted average of the set of observations sensed by the active agents. Existing active-passive dynamic consensus filters in the classical sense assume that all agents can be modeled as having single integrator dynamics, which may not always hold in practice. Motivating from this standpoint, the contribution of this paper is to introduce a new class of active-passive dynamic consensus filters, where agents have (homogeneous) linear time-invariant dynamics. We demonstrate that for output controllable agents, the output of all active and passive agents converge to a neighborhood of the weighted average of the set of applied exogenous inputs. A numerical example is also given to illustrate the efficacy of the presented theoretical results.