gebhart/patrepeval huggingface dataset:
Creeping Self-Reliance in Malaysia (1970)

Essay| December 01 1970 Creeping Self-Reliance in Malaysia Stephen A. Douglas Stephen A. Douglas Assistant Professor of Political Science, University of Illinois Stephen A. Douglas is author of Political Socialism and Student Activism in Indonesia (Urbana, Ill.: University of Illinois Press, 1970). Prior to 1965, he served as a training associate in the Ford Foundation’s Indonesia Field Office. In 1969, he conducted field research in Malaysia. Search for other works by this author on: This Site PubMed Google Scholar Current History (1970) 59 (352): 345–350. https://doi.org/10.1525/curh.1970.59.352.345 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Stephen A. Douglas; Creeping Self-Reliance in Malaysia. Current History 1 December 1970; 59 (352): 345–350. doi: https://doi.org/10.1525/curh.1970.59.352.345 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCurrent History Search This content is only available via PDF. © 1970 by The Regents of the University of California1970 Article PDF first page preview Close Modal You do not currently have access to this content.
Cytokine-independent Jak3 Activation upon T Cell Receptor (TCR) Stimulation through Direct Association of Jak3 and the TCR Complex (2001)

Jak3 is responsible for growth signals by various cytokines such as interleukin (IL)-2, IL-4, and IL-7 through association with the common gamma chain (gammac) in lymphocytes. We found that T cells from Jak3-deficient mice exhibit impairment of not only cytokine signaling but also early activation signals and that Jak3 is phosphorylated upon T cell receptor (TCR) stimulation. TCR-mediated phosphorylation of Jak3 is independent of IL-2 receptor/gammac but is dependent on Lck and ZAP-70. Jak3 was found to be assembled with the TCR complex, particularly through direct association with CD3zeta via its JH4 region, which is a different region from that for gammac association. These results suggest that Jak3 plays a role not only in cell growth but also in T cell activation and represents cross-talk of a signaling molecule between TCR and growth signals.
Siah-1b is a direct transcriptional target of p53: Identification of the functional p53 responsive element in the siah-1b promoter (2004)

Siah proteins are E3 ubiquitin ligases. They are homologues of the Drosophila seven in absentia (Sina), a protein required for the R7 photoreceptor development. We have previously found that the expression of human siah-1 and its mouse homologue siah-1b are induced by p53 during apoptosis and tumor reversion. So far, no evidence that the siah-1b gene is a direct transcriptional target of p53 has been provided. In the present study we investigate this issue. Northern blot analysis with a specific probe demonstrates an increase in siah-1b transcription on activation of endogenous and inducible exogenous p53. To explore whether this effect is directly mediated by p53 we analyzed 20 kb of chromosome X DNA, containing the siah-1b locus. A p53-binding site was identified in the siah-1b promoter, located at nucleotides -2155/-2103 relative to the translational start site. This site is composed of two half-sites, conforming to the p53-binding consensus sequence but separated by a nonclassical 33-bp spacer. In luciferase assays, p53 induces a substantial increase in siah-1b promoter activity. Gel shift and DNase-I-footprinting studies, combined with mutational analysis and chromatin immunoprecipitation, indicate that p53 effectively binds the siah-1b promoter in vitro and in vivo. Thus, the siah-1b gene is a direct transcriptional target of p53.
Investigation into variable‐addressibility image sensor and display systems (1998)

Abstract— The eye's acuity varies across its field of view, decreasing to 10% of its axial value at only 20°. This creates a situation where standard displays, when used in conjunction with the eye, present more information than can be perceived. This paper describes an optical system that has been developed that radially re‐maps the pixels of a miniature display or sensor to match the varying acuity of the eye across its field of view. This system increases the field of view of an electronic viewing system without any apparent loss in image quality.
Src family kinases and pulmonary fibrosis: A review (2020)

Src family kinases (SFKs) is a non-receptor protein tyrosine kinases family. They are crucial in signal transduction and regulation of various cell biological processes, such as proliferation, differentiation and apoptosis. The role and mechanism of SFKs in tumorigenesis have been widely studied. However, more and more studies have also shown that SFKs are involved in the pathogenesis of pulmonary fibrosis (PF). Myofibroblasts activation, epithelial-mesenchymal transition and inflammation response are three pivotal pathomechanisms in the development of pulmonary fibrotic disease. In this article, we summarize the roles of SFKs in these biological processes. SFKs play a crucial role in the pathogenesis of PF, making it a promising molecular target for the treatment of these diseases. We will pay special attention to the role of SFKs in idiopathic pulmonary fibrosis (IPF), and also emphasize the important findings in other pulmonary fibrotic diseases because their pathological mechanisms are similar. We will then describe the translation results obtained with SFKs inhibitors in basic and clinical studies.
A Simple Method for Examining the Electrochemistry of Metalloporphyrins and Other Hydrophobic Reactants in Thin Layers of Organic Solvents Interposed between Graphite Electrodes and Aqueous Solutions (1998)

A method is described for the preparation of stable, adherent, thin layers of organic solvents interposed between the surfaces of graphite electrodes and aqueous supporting electrolytes in which they are immersed. The electrochemistry of reactants dissolved in the thin layers is examined and utilized to evaluate surface coverages and formal potentials for molecules, such as cobalt tetraphenylporphyrins, that do not exhibit useful electrochemical responses when adsorbed on graphite. The thin layers of organic solvent can be used to concentrate analytes by extracting them from dilute aqueous solutions to produce enhanced sensitivity in electroanalytical applications. Electron transfer across the liquid/liquid interface created by the presence of the thin layer of immiscible organic solvent is also demonstrated.
<title>High-performance backlights for liquid crystal displays</title> (1994)

New applications of LCDs (liquid crystal displays) particularly in cockpits will require very high performance backlights. We have developed a new type of backlight particularly suitable for these requirements. Device characteristics and predicted performance figures for specific cockpit applications are given.
GENE EXPRESSION STUDIES USING MICROARRAYS: PRINCIPLES, PROBLEMS, AND PROSPECTS (2002)

A number of mammalian genomes having been sequenced, an important next step is to catalog the expression patterns of all transcription units in health and disease by use of microarrays. Such discovery programs are crucial to our understanding of the gene networks that control developmental, physiological, and pathological processes. However, despite the excitement, the full promise of microarray technology has yet to be realized, as the superficial simplicity of the concept belies considerable problems. Microarray technology is very new; methodologies are still evolving, common standards have yet to be established, and many problems with experimental design and variability have still to be fully understood and overcome. This review will describe the time course of a microarray experiment-RNA isolation from sample, target preparation, hybridization to the microarray probe, data capture, and bioinformatic analysis. For each stage, the advantages and disadvantages of competing techniques are compared, and inherent sources of error are identified and discussed.
Structure Elucidation of Germacrane Alcohols from Juniperus communis subsp. Hemisphaerica (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure Elucidation of Germacrane Alcohols from Juniperus communis subsp. HemisphaericaArturo San Feliciano, Manuel Medarde, Marina Gordaliza, and Maria J. LucasCite this: J. Nat. Prod. 1995, 58, 7, 1059–1064Publication Date (Print):July 1, 1995Publication History Published online1 July 2004Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/np50121a011https://doi.org/10.1021/np50121a011research-articleACS PublicationsRequest reuse permissionsArticle Views294Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PS Natural Fractures in the New Albany Shale, Illinois Basin, and Their Importance for Shale-Gas Production* (2010)

Success in the New Albany Shale gas play in southern Indiana and western Kentucky, where gas is mostly thermogenic, is partly dependent on understanding how the natural fracture system impacts hydraulic fracture treatments. We consider both the potential for natural fractures to provide permeability enhancement and their potential effects on hydraulic fracture treatment efficiency. We present observations from outcrops in the Illinois Basin in Kentucky and across the Cincinnati Arch into the Appalachian Basin and from cores from Indiana (10 cores) and Kentucky (2 cores) in the Illinois Basin. The structural grain of the two areas ‐ southern Indiana and western Kentucky ‐ is fundamentally different. Southern Indiana is dominated by the Wabash Valley normal fault system, which is currently active and trends approximately N‐S. Western Kentucky is dominated by the E‐W trending Rough Creek Graben. The major and minor faults and opening‐mode fractures in part reflect this difference. The present‐day in situ stress must be determined on a site‐specific basis. The World Stress Map database suggests a swing in the maximum horizontal stress direction from ENE in southern Indiana to E‐W in western Kentucky. The large difference in underlying local structure might have a significant perturbation effect on the far‐field stress orientation. Steep, sealed, or partly sealed fractures, some of which are sheared, are present in several of the cores. They contain both carbonate and quartz cements. These sets are likely to be important either for enhancing permeability or as influences over hydraulic fracture propagation. Compacted, fibrous, quartz‐dolomite‐bitumen veins are present in the basal Blocher Member in some outcrops. The veins are up to 14 cm wide and mostly < 1 m in height, and commonly contain bitumen in vuggy openings. For completions in the usually‐targeted Clegg Creek Member it is unlikely that these large veins will affect production, but they could affect completions in
Calorimetric investigations of solids by combined FPPE – TWRC method (2010)

An alternative photopyroelectric (PPE) technique that combines the front detection configuration (FPPE) with the thermal-wave-resonator-cavity (TWRC) method is proposed for direct measurement of thermal effusivity of solid materials inserted as backings in the FPPE detection cell. The method uses the scan of the normalized PPE phase as a function of sample's thickness, in the thermally thin regime for the sensor and liquid layer, and thermally thick regime for the backing material. The value of backing's thermal effusivity results from the optimization of the fit of the phase of the signal, performed with sample's thickness and backing's thermal effusivity as fitting parameters. The paper presents experimental results on several solid materials (inserted as backing in the cell), with different values of thermal effusivity (brass, steel, wood) and two liquids (ethylene glycol, water) largely used in the FPPE-TWRC cells. The paper stresses mainly on the sensitivity of the technique to different liquid/backing effusivity ratios. It seems that the method is suitable especially when investigating solids with values of thermal effusivity close to the effusivity of the liquid layer.
Utilization of mining and mineral wastes (1998)

Up to now, it is estimated that more than 50 million tons of mineral wastes have been generated mining industries and deposited on the land in Korea. Much of cultivated land and hilly areas have been occupied by this wastes, which cause pollution of the environment. Utilization of the mineral wastes is preferable to stabilization because full use would both eliminate the waste and broaden the mineral resource base. Therefore, the development of utilization techniques of mineral wastes is very important not only for improving the environment but also for resource conservation. In countries with high population and poor natural resources like Korea, the utilization of these wastes is essential to decrease the environmental problem and the secure the resources and the study on this field play a important part. Therefore, the objective of this study is to develop the utilization techniques of the mineral wastes. In first year's research, the contents and scope of this study are 1) Present condition and Field Survey on the mineral wastes with respect of their utilization, 2) Reviews of Current effects and research to utilize mineral wastes, 3) Characterization of mineral wastes and environmental test, 4) Evaluation and study on the utilization. (author). 67 refs., 25 tabs., 54 figs.
Prevalence of enterotoxigenic Escherichia coli-associated diarrhoea and carrier state in the developing world. (2004)

This study assesses the importance of enterotoxigenic Escherichia coli (ETEC) as a diarrhoeal agent in developing countries. Odds ratios were calculated for incurring ETEC-associated diarrhoea based on data reported between 1970 and 1999. Carriage of ETEC was associated with diarrhoea in children aged less than five years, except for hospitalized infants aged 0-11 month(s) and children aged 1-4 year(s) at outpatient clinics. Two hundred and eighty million episodes of diarrhoea due to ETEC were seen yearly among those aged less than five years, and close to 50 million children of this age group were asymptomatic carriers of ETEC. Every 7th diarrhoeal episode in children aged less than one year and close to 25% of diarrhoeal cases in children aged 1-4 year(s) were due to ETEC. A child born in a developing country is likely to experience 0.5 diarrhoeal episodes per year caused by ETEC until the age of five years, after which the yearly incidence drops to 0.1. To conclude, ETEC remains an important diarrhoeal pathogen among children in the developing world.
Photon dynamics of amplified and damped cavity fields (2012)

Abstract We have derived a quantum trajectory model for describing the dynamics of cavity fields of optoelectronic devices. We apply the model to describe the photon statistics of semiconductor devices. The model is based on three parameters: the injected current, the electron‐photon coupling in semiconductor active material, and the cavity loss rate. The model can be applied to solve the steady state photon statistics of various device configurations and also describe the transient phenomena. We show that depending on the parameters the device can operate e.g. as a light emitting diode or as a laser. We also investigate the photon correlation properties and discuss the photon bunching and anti‐bunching phenomena. (© 2012 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Impact of external-beam radiation therapy on outcomes among patients with resected gastric cancer: A multi-institutional analysis. (2014)

4011 Background: Use of perioperative chemotherapy (CTx) alone versus chemo-radiation therapy (cXRT) in the treatment of resectable gastric cancer remains varied. We sought to define the utilization and effect of CTx alone versus cXRT on patients having undergone curative-intent resection for gastric cancer. Methods: Using the multi-institutional U.S. Gastric Cancer Collaborative database, we identified 505 patients between 2000 and 2012 with gastric cancer who received perioperative therapy in addition to curative-intent resection. The impact of perioperative therapy on survival was analyzed by the use of propensity-score matching of clinicopathologic factors among patients who received CTx alone versus cXRT. Results: Median patient age was 62 years and the majority of patients were male (58%). Surgical resection involved either partial gastrectomy (54%) or total gastrectomy (46%). On pathology, median tumor size was 5.0 cm; most patients had a T3 (37%) or T4 (36%) lesion and lymph node metastasis (74%). Margin status was R0 in most patients (89%). 211 (42%) patients received perioperative CTx alone whereas the remaining 294 (58%) patients received 5-FU based cXRT. Factors associated with receipt of cXRT were younger age (OR 0.98), T3 tumors (OR 1.52), and lymph node metastasis (OR 2.03) (all P < .05). Recurrence occurred in 214 (39%) patients. At a median follow-up of 28 months, median overall survival (OS) was 33.4 months and 5-year survival was 36.7%. Factors associated with worse OS included tumor size (HR 1.1), T-stage (HR 1.5), and lymph node metastasis (HR 1.58) (all P<0.05). In contrast, receipt of cXRT was associated with improved long-term OS (CTx alone: 21 months vs. cXRT 45 months; p<0.001). In the propensity-matched multivariate model that adjusted for tumor size, T-stage, and nodal status, cXRT remained associated with an improved long-term disease-free (HR 0.43) and overall (HR 0.41) survival (both P<0.001). Conclusions: XRT was utilized in 58% of patients undergoing curative-intent resection for gastric cancer. Using propensity-matched analysis, cXRT was an independent factor associated with improved recurrence-free and overall survival.
Strukturen der Organisationsberatungsinteraktion : objektiv hermeneutische Untersuchung zur Professionalisierungsbedürftigkeit der Organisationsberatung ; Anhangband: Inventare und Transkripte (2010)

Das Dokument enthält den Anhang zur Dissertation: "Strukturen der Organisationsberatungsinteraktion. Objektiv Hermeneutische Untersuchung zur Professionalisierungsbedüftigkeit der Organisationsberatung". Der Dissertationstext ist in 11/2010 bei Vandenhoeck &amp; Ruprecht in der Reihe "Interdisziplinäre Beratungsforschung" erschienen.\nDer hier veröffentlichte Anhang enhält die Transkripte und Inventare der in dieser Studie analysierten Organisationsberatungsgespräche.\nKurzzusammenfassung des Dissertationstextes:\nDie Studie ist eine der ersten methodisch abgesicherten Untersuchungen zu authentischem Material von Interaktionen aus der Organisationsberatung. Der Studie liegt die Frage zugrunde, ob die Organisationsberatung als professionalisierungsbedürftig beurteilt werden kann. Über diese konkrete Fragestellung hinausweisend werden im Verlauf des Textes Erkenntnisse dazu erarbeitet, welchen methodischen Zugriff und welche forschungsstrategischen Entscheidungen die Arbeit mit Material aus der Organisationsberatung erfordert. Die Studie umreißt somit ein Arbeitsprogramm, das für die Erforschung der Organisationsberatung als Teil einer Beratungswissenschaft zielführend sein kann.\nZunächst wird anhand von sieben Fallstudien zu authentischem Material von Gesprächen der Organisationsberatung gezeigt, wie mittels dieser Interaktionsanalysen die Professionalisierungsbedürftigkeit der Organisationsberatung systematisch in Zweifel gezogen werden kann, ohne diesen Schluss theoretisch herleiten zu müssen. Dazu werden die Verhältnisse in der Organisationsberatung mit den Professionalisierungsansprüchen, wie sie bisher aus der Beratung von Personen abgeleitet wurden, verglichen. Die Nutzung dieses Vergleiches verspricht, die Beantwortung der Frage nach der Professionalisierungsbedürftigkeit der Organisationsberatung eng an die Beschaffenheit der Organisation als Gegenstand dieser Beratungsform zu knüpfen. Über den Befund hinaus, dass die Organisationsberatung aufgrund bestimmter Grundmerkmale von Organisationen nicht professionalisierungsbedürftig ist, werden im Rahmen der vorgestellten Studie aber auch Leitlinien für zielführende Forschungsstrategien im Feld der Organisationsberatung entwickelt.
Benzodiazepines as Potent and Selective Bradykinin B1 Antagonists (2003)

Antagonism of the bradykinin B(1) receptor was demonstrated to be a potential treatment for chronic pain and inflammation. Novel benzodiazepines were designed that display subnanomolar affinity for the bradykinin B(1) receptor (K(i) = 0.59 nM) and high selectivity against the bradykinin B(2) receptor (K(i) > 10 microM). In vivo efficacy, comparable to morphine, was demonstrated for lead compounds in a rodent hyperalgesia model.