gebhart/patrepeval huggingface dataset:
Endoscopic vacuum therapy and early surgical closure after pelvic anastomotic leak: meta-analysis of bowel continuity rates (2022)

EVT is associated with satisfactory stoma reversal rates that may be improved if it is combined with ESC.
Soluble CD90 as a potential marker of pulmonary involvement in systemic sclerosis (2012)

sCD90 concentrations were increased in the sera of SSc patients, particularly in patients with vascular involvement of the lungs. These data suggest that sCD90 should be further evaluated as a marker for diagnosis of PAH in SSc.
Biomimetic Cell Structures: Probing Induced pH-Feedback Loops and pH Self-Monitoring in Cytosol Using Binary Enzyme-Loaded Polymersomes in Proteinosome (2023)

Structures and functions of eukaryotic cells with an outer permeable membrane, a cytoskeleton, functional organelles, and motility can be mimicked by giant multicompartment protocells containing various synthetic organelles. Herein, two kinds of artificial organelles with stimuli-triggered regulation ability, glucose oxidase-(GOx)-loaded pH-responsive polymersomes A (GOx-Psomes A) and urease-loaded pH-responsive polymersomes B (Urease-Psomes B), and a pH-sensor (Dextran-FITC) are encapsulated into proteinosomes via the Pickering emulsion method. Thus, a polymersomes-in-proteinosome system is constructed which is able to probe biomimetic pH homeostasis. Alternating fuels (glucose or urea) introduced from outside the protocell penetrate the membrane of proteinosomes and enter into GOx-Psomes A and Urease-Psomes B to produce chemical signals (gluconic acid or ammonia) resulting in pH-feedback loops (pH jump and pH drop). This will counteract the catalytic "switch on" or "switch off" of enzyme-loaded Psomes A and B owing to their different pH-responsive membranes. Dextran-FITC in the proteinosome allows self-monitoring of slight pH fluctuations in the lumen of protocells. Overall, this approach shows heterogeneous polymersome-in-proteinosome architectures with sophisticated features such as input-regulated pH changes mediated by negative and positive feedback in loops and cytosolic pH self-monitoring, features that are imperative for advanced protocell design.
Dispatching in an integrated circuit wafer fabrication line (1989)

Wafer Fabrication has been described as the most complicated manufacturing environment existing today. This paper describes a method used to dispatch lots in one of AT&T's Wafer Fabrication Clean Rooms. The objective is to minimize idle time on important facilities in the clean room. For each lot in the clean room, the method indicates the slack time the lot can incur before it is needed at the next important facility group in its route. The slack time is the amount of time the lot can be delayed in queue with the implication that a lot with a smaller slack time needs to be processed more urgently than a lot with a larger slack time.
ChemInform Abstract: A General and Versatile Route to “Zinc Finger” Templates. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Angiotensin II Upregulates Toll-Like Receptor 4 on Mesangial Cells (2006)

Angiotensin II (AngII) mediates proinflammatory properties by activating NF-kappaB transcription factor nuclear translocation and inducing the expression of chemokines. For examination of whether AngII modulates the expression of Toll-like receptor 4 (TLR4), a key element of the innate immune system that senses LPS, mouse mesangial cells (MMC) were treated with AngII. AngII upregulated TLR4 mRNA and protein in MMC, and this effect was mediated through AngII type 1 receptors. Reporter gene experiments indicate that an activating protein-1 (AP-1) as well as an E-26 specific sequence (Ets) binding site in the TLR4 promoter are responsible for the AngII-stimulated transcriptional activity of the TLR4 gene. Preincubation of MMC with AngII enhanced LPS-induced NF-kappaB activation and chemokine expression. Immunohistochemical analyses revealed that double-transgenic rats that overexpressed human renin and angiotensinogen expressed higher levels of glomerular TLR4 compared with normal Sprague-Dawley rats. In vivo, infusion with AngII but not with norepinephrine into rats for 7 d also enhanced glomerular NF-kappaB activation after systemic application of LPS, suggesting that the effects are independent of concomitantly induced hypertension. Together, these observations suggest that AngII leads to an activation of the innate immune system by a novel mechanism involving the upregulation of TLR4. Our data contribute to a better understanding of how exogenous infections may trigger renal autoimmune processes, particularly in pathophysiologic situations with high renal AngII concentrations. Because TLR4 binds endogenous ligands (e.g., extracellular matrix components) in addition to microbial products, AngII-mediated upregulation of TLR4 also could be relevant for the development of inflammation in many noninfectious renal diseases.
Urea Amidolyase (1972)

Candida utilis contains an inducible enzyme, urea amidolyase, which catalyzes the decomposition of urea with formation of carbon dioxide and ammonia. This reaction is accompanied by the cleavage of ATP with liberation of equimolar amounts of ADP and inorganic phosphate, is strictly dependent for activity on divalent (Mg++ or Mn++) and monovalent (K+, Rb+, Cs+, or NH4+) cations, and requires catalytic amounts of bicarbonate. A detailed consideration of these properties is presented for the enzyme purified approximately 150-fold from C. utilis. Urea amidolyase activity is induced in C. utilis by urea and other substances which most likely are enzymatically degraded to urea. Repression of the enzyme occurs when low evels of ammonia are present in the medium. Extracts of other yeasts, such as Candida flareri and Saccharomyces cerevisiae, as well as of the unicellular green algae Chlorella ellipsoidea, Chlorella pyrenoidosa, and Chlamydomonas reinhardtii, also contain urea amidolyase activity when these organisms are grown in media containing urea as the sole source of nitrogen.
Social Participation and the Prevention of Functional Disability in Older Japanese: The JAGES Cohort Study (2014)

Social participation may decrease the risk of incident functional disability in older people in Japan. This effect may be strengthened by participation in a variety of different types of organizations. Participating in a local community, hobby, or sports group or organization may be especially effective for decreasing the risk of disability.
A Quantitative Assessment of Wound Healing With Oxygenated Micro/Nanobubbles in a Preclinical Burn Model (2021)

These preliminary findings propose the potential of MNB(O2) as a topical method for improving burn wound healing.
RETRACTED: Epac1‐induced cellular proliferation in prostate cancer cells is mediated by B‐Raf/ERK and mTOR signaling cascades (2009)

cAMP-dependent, PKA-independent effects on cell proliferation are mediated by cAMP binding to EPAC and activation of Rap signaling. In this report, we employed the analogue 8-CPT-2-O-Me-cAMP to study binding to EPAC and subsequent activation of B-Raf/ERK and mTOR signaling in human cancer cells. This compound significantly stimulated DNA synthesis, protein synthesis, and cellular proliferation of human 1-LN prostate cancer cells. By study of phosphorylation-dependent activation, we demonstrate that EPAC-mediated cellular effects require activation of the B-Raf/ERK and mTOR signaling cascades. RNAi directed against EPAC gene expression as well as inhibitors of ERK, PI 3-kinase, and mTOR were employed to further demonstrate the role of these pathways in regulating prostate cancer cell proliferation. These studies were then extended to several other human prostate cancer cell lines and melanoma cells with comparable results. We conclude that B-Raf/ERK and mTOR signaling play an essential role in cAMP-dependent, but PKA-independent, proliferation of cancer cells.
ChemInform Abstract: ν‐Triazolines. Part 36. New Synthesis of Ethyl 1‐Alkyl‐1,4,5,6‐ tetrahydro‐6‐oxopyridine‐3‐carboxylates and 1‐Alkyl‐1,4,5,6‐tetrahydro‐ 6‐oxopyridine‐3‐carbonitriles Through Reduction of N‐2‐ Nitroarylamidines. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Doxorubicin‐Loaded Polymeric Micelle Overcomes Multidrug Resistance of Cancer by Double‐Targeting Folate Receptor and Early Endosomal pH (2008)

An optimized, pH-sensitive mixed-micelle system conjugated with folic acid is prepared in order to challenge multidrug resistance (MDR) in cancers. The micelles are composed of poly(histidine (His)-co-phenylalanine (Phe))-b-poly(ethylene glycol) (PEG) and poly(L-lactic acid) (PLLA)-b-PEG-folate. Core-forming, pH-sensitive hydrophobic blocks of poly(His-co-Phe) of varying composition are synthesized. The pH sensitivity of the micelles is controlled by the copolymer composition and is fine tuned to early endosomal pH by blending PLLA(3K)-b-PEG(2K)-folate in the presence of a basic anticancer drug, doxorubicin (DOX). In vitro tests are conducted against both wild-type (A2780) and DOX-resistant ovarian carcinoma cell lines. A mixed-micelle system composed of poly(His-co-Phe (16 mole%))-b-PEG (80 wt%) and PLLA-b-PEG-folate (20 wt%) is selected to target early endosomal pH. DOX-loaded micelles effectively kill both wild-type sensitive (A2780) and DOX-resistant ovarian MDR cancer-cell lines (A2780/DOX(R)) through an instantaneous high dose of DOX in the cytosol, which results from active internalization, accelerated DOX release triggered by endosomal pH, and an endosomal membrance disruption.
Effect of Sorbed Water on the Dielectric Properties of Acetylene‐Terminated Polyimide Resins and Their Application to a Humidity Sensor (1993)

A cured acetylene‐terminated polyisoimide oligomer was used to prepare a capacitive‐type humidity sensor. Sorption behavior of water on the cured film was examined by measuring the dielectric constant and water content. The amount of sorbed water was small and the sorbed water did not form clusters. This is due to the hydrophobic nature and rigid structure of the film. The sorption behavior reflects its excellent sensor properties, i.e., low hysteresis, low temperature coefficient, durability against acetone vapor, and long‐term stability in a high temperature and humid atmosphere. Among the polyimides prepared by curing the oligomers with different chain lengths, the most suitable composition for a reliable capacitive‐type humidity sensor was API‐3‐API‐1.
Application of shallow shear-wave seismic reflection methods in earthquake hazards studies (2010)

In engineering geophysics, the use of shear-wave seismic methods for earthquake hazards analysis has primarily been limited to site-specific downhole, crosshole, and refraction studies for velocities to model site response to earthquake shaking and/or liquefaction potential. This paper demonstrates the utility of S-wave reflection methods in earthquake hazards studies, focusing on areas where collection of high-quality compressional-wave reflection data is problematic. Specific examples will show how S-wave reflection data help interpret the age, style, and extent of near-surface deformation in the New Madrid seismic zone of the central United States, and in mapping the Holocene-Pleistocene surface beneath the Fraser River delta in southwestern British Columbia (Canada).
Additive manufacturing of polymer‐derived ceramic matrix composites (2020)

Abstract This study presents a fabrication method and identifies processing bounds for additively manufacturing (AM) ceramic matrix composites (CMCs), comprising a silicon oxycarbide (SiOC) ceramic matrix. A digital light projection printer was used to photopolymerize a siloxane‐based preceramic resin containing inert ceramic reinforcement. A subsequent pyrolysis converted the preceramic polymer to SiOC. Particle reinforcements of 0 to 40% by volume in the green state were uniformly dispersed in the printed samples to study their effects on pyrolysis mass loss and shrinkage, and CMC notch sensitivity and strength. Both particle and whisker reinforcements toughened the glassy SiOC matrix (1 MPa m 1/2 ), reaching values &gt;3 MPa m 1/2 . Bending strengths of &gt;300 MPa (&gt;150 MPa (g cm −3 ) −1 ) and a Weibull modulus of 10 were measured on AM samples without surface finish. We identified two pore formation mechanisms that placed processing bounds on sample size and reinforcement volume fraction. Methods for increasing these bounds are discussed. With properties commensurate to traditionally processed technical ceramics, the presented process allows for free‐form fabrication of high‐performance AM CMC components.
Integer Ambiguity Resolution by Mixture Kalman Filter for Improved GNSS Precision (2020)

Accurate carrier-phase integer ambiguity resolution is fundamental to high-precision global navigation satellite systems (GNSSs). Real-time GNSSs typically resolve the ambiguities by a combination of recursive estimators and integer least-squares solvers, which need to be reset when satellites are added or cycle slip occurs. In this article, we propose a mixture Kalman filter solution to integer ambiguity resolution. By marginalizing out the set of ambiguities and exploiting a likelihood proposal for generating the ambiguities, we can bound the possible values to a tight and dense set of integers. Thus, we extract the state and integer estimates from a mixture Kalman filter. The proposed approach yields an integrated method to detect cycle slip and initialize new satellites. Numerical analysis and experimental results indicate that the proposed method achieves reliable position estimates, repeatedly finds the correct integers in cases when other methods may fail, and is more robust to cycle slip.
The satiating effect of egg is higher than fresh cheese in humans (2011)

The satiating effect of egg is higher than fresh cheese in humans
An Immobilized Biotin Ligase: Surface Display of Escherichia coli BirA on Saccharomycescerevisiae (2005)

The Escherichia coli biotin ligase enzyme BirA has been extensively used in recent years to generate site-specifically biotinylated proteins via a biotin acceptor peptide tag. In the present study, BirA was displayed for the first time on the yeast Saccharomyces cerevisiae using the Aga1p-Aga2p platform and assayed using a peptide-tagged protein as the substrate. The enzyme is fully functional and resembles the soluble form in many of its properties, but the yeast-displayed enzyme demonstrates stability and reusability on the time scale of weeks. Thus, the yeast-displayed BirA system represents a facile and highly economical alternative for producing site-specifically biotinylated proteins.
Examining the precipitation associated with medicanes in the high‐resolution ERA‐5 reanalysis data (2020)

Abstract Medicanes, hurricane‐like cyclonic systems in the Mediterranean Sea, are becoming an increasingly severe problem for many Mediterranean countries because climate projections suggest a higher risk under anthropogenic forcing even under an intermediate scenario. Due to the small size of these weather systems, high‐resolution data are required to better resolve their structure and evolution. Here we investigate medicanes from the perspective of precipitation using the high‐resolution (0.25°) ERA‐5 reanalysis data released by European Centre for Medium‐Range Weather Forecasts. Overall, we identify a total of 59 medicanes from ERA‐5 data during 1979–2017, with marked year‐to‐year variability. These storms tend to occur mostly between September and March. Overall, the intensity of medicanes (i.e., maximum wind) is lower than that of tropical cyclones, and this is also true for precipitation. The composite precipitation of medicanes increases from the centre to ~0.8° and then decreases. During 1979–2017, many regions along the Mediterranean Sea experienced over 20 extreme precipitation events (i.e., days) which were caused by medicanes, accounting for 2–5% of all the extreme precipitation events.
A Novel Device To Assess Eccentric Grip Strength (2020)

PURPOSE: To determine normative values for eccentric grip strength derived from an original device in general Japanese populations and to investigate the relationship between isometric grip strength and eccentric grip strength. METHODS: In the present study, 102 subjects (32 men: age 61.5±11.0 years, height 170.6±6.7 cm, weight 68.2±9.8 kg; 70 women: age 60.7±14.9 years, height 156.0±7.4 cm, weight 52.4±7.2 kg) participated. Isometric grip strength was assessed using a dynamometer (Takei, Co., Ltd, Tokyo, Japan). The peak force of eccentric grip strength was assessed using an original device. The device utilized an AC servo motor (60 W class) to generate eccentric force to unclench the subject's hand at a constant speed of 32.67 mm/s. Intra-class correlation coefficients (ICCs) and coefficients of variation (CVs) were calculated for the variables of interest. RESULTS: The isometric grip strength was 39.2±7.8 kg and 25.6±4.7 kg in men and women, respectively. The peak eccentric grip strength was 50.0±12.1 kg and 30.9±7.2 kg in men and women, respectively. The CV tended to be higher in the eccentric grip strength (26-26.6%) than in the isometric grip strength group (18.7-20.0%). The ICC of eccentric grip strength was 0.944-0.953 for both groups. CONCLUSIONS: Based on these findings, it is suggested that the eccentric grip strength device shows good test-retest reliability. In addition, the eccentric grip strength is 20.7-27.5% higher than the isometric grip strength in the general population.
Audio-Based Cover Song Retrieval Using Approximate Chord Sequences: Testing Shifts, Gaps, Swaps And Beats. (2007)

[TODO] Add abstract here.
Self-assembly of block copolymer-based ionic supramolecules based upon multi-tail amphiphiles (2015)

Using synchrotron small angle X-ray scattering (SAXS), self-assembly of ionic supramolecules based upon diblock copolymers of poly(styrene)-<italic>b</italic>-poly(methacrylic acid) and multi-tail (2- or 4-tail) alkyl quaternary ammonium amphiphiles is investigated.
Platinum(II) Acetylides in the Formal [2+2] Cycloaddition‐Retroelectrocyclization Reaction: Organodonor Versus Metal Activation (2013)

Abstract Formal cycloaddition‐retroelectrocyclization (CA‐RE) reactions between electron‐donor‐activated alkynes and electron‐poor alkenes yielding cyanobuta‐1,3‐dienes have recently attracted increasing interest. The transformation has been subjected to a fundamental investigation of the relative degrees of alkyne activation by organic and metallorganic donor substituents by using platinum(II) σ‐acetylides as model substrates and studying their behavior towards the cyano carbons TCNE and TCNQ. Various cyanobutadienes were obtained in good to excellent yields and four trends in reactivity were discerned: 1) The presence of an anilino substituent clearly dominates the regioselectivity of the TCNQ addition. 2) In the absence of an organodonor, the regioselectivity is inverted. 3) When platinum(II) complexes of buta‐1,3‐diynes are used, the addition always takes place at the triple bond distal to the metal center. 4) In general, trans ‐bis‐acetylides are more reactive than the corresponding cis complexes. The structural parameters of the CA‐RE adducts were investigated by X‐ray crystallography and their optical properties by UV/Vis spectroscopy, giving further insights into the structural trends and degree of intramolecular charge transfer. These fundamental investigations may enable the synthesis of new Pt‐based molecular dyads in which the effect of regioselectivity on photoinduced charge separation can be studied.
Prebiotics and Probiotics: Some Thoughts on Demonstration of Efficacy Within the Regulatory Sphere (2012)

Probiotics and prebiotics present regulators with challenges because they require a demonstrated positive health outcome and proof that the prebiotic or probiotic is the agent of action once safety aspects have been satisfied. Thus, probiotic and prebiotic definitions are important because they will set the criteria by which these materials will be judged within the regulatory sphere. Use of the terms probiotic and prebiotic are, themselves, considered health claims in some jurisdictions, so that both product health claims and product content labeling may be regulated. Currently accepted definitions of prebiotic and probiotic make it easier to draw a straight line between ingestion and health outcome for probiotics but much more difficult for prebiotics, where a health outcome must be linked to changes in specific bacterial species within the gut microbial community. These challenges highlight the difficulties facing regulatory bodies and the scientific community when emerging science is turned into consumable product.
Concentrator of laser energy for thin vapor-cloud production near a surface (1998)

A novel scheme is presented for the production of a thin (<1 mm) uniform vapor layer over a large surface area (>100 cm2) by pulsed laser ablation of a solid surface. Instead of dispersing the laser energy uniformly over the surface, a modified Fabry–Perot interferometer is employed to concentrate the laser energy in very narrow closely spaced concentric rings. This approach may be optimized to minimum total laser energy for the desired vapor density. Furthermore, since the vapor is produced from a small fraction of the total surface area, the local ablation depth is large, which minimizes the fraction of surface contamination in the vapor.
Increased Incidence of Tachyarrhythmias and Heart Failure Hospitalization in Patients With Implanted Cardiac Devices After the Great East Japan Earthquake Disaster (2012)

Background: After the East Japan Earthquake disaster there may have been a deterioration of patients with cardiovascular diseases. Methods and Results: We examined the data from 189 consecutive patients implanted with cardiovascular devices for the 6-month period before and after the Earthquake. In 170 patients with defibrillators, the number who experienced tachyarrhythmias increased significantly after the Earthquake (28±5 vs. 34±3 patients/month, P<0.05). In 74 patients with biventricular pacemakers, the number of heart failure hospitalizations significantly increased after the Earthquake (1.2±1.0 vs. 2.7±1.2 patients/month, P<0.05). Conclusions: The East Japan Earthquake disaster unfavorably affected patients implanted with defibrillators or biventricular pacemakers. (Circ J 2012; 76: 1283-1285)
ChemInform Abstract: Lithium and Sodium Alkoxy‐ and Aryloxyhydridoaluminates in Solution and in the Solid State. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.