gebhart/patrepeval huggingface dataset:
5.4.1 Potentials of Capacitive Micromachined Ultrasonic Transducers (CMUT) and Film Bulk Acoustic Wave Resonators (FBAR) for Gas Sensing -an Industrial Point of View (2012)

Various types of acoustic wave sensors have been investigated for gas sensing applications, but only a view of them are in industrial use until now. This works compares the recent development of two MEMS based acoustic transducers for gas sensors: The electrostatic driven Capacitive Micromachined Ultrasonic Transducer (CMUT) and the piezoelectric Film Bulk Acoustic Resonator (FBAR). Main characteristics of current transducers are compared with respect to their applicability for industrial gas sensors. The detection of CO 2 is investigated using a polysiloxane based sensing layer.
Nanocarriers for Cytosolic Drug and Gene Delivery in Cancer Therapy (2011)

In this burgeoning era of personalized medicine we have witnessed a humongous increase in novel therapeutics encompassing wide range of modalities including small molecule drugs which can elicit their action upon encountering certain cellular component, protein macromolecules interfering cellular signaling pathways and nucleotide and DNA based therapies which alter protein/gene expression (Gonzalez-Angulo et al., 2010). The major factor which underscores the success of these novel therapeutic modalities is their propensity to reach the target site of action. Undoubtedly, the ultimate target for all these therapeutic modalities according to traditional paradigm is the cell. But there is a need for change in this paradigm since many of these modalities are targeted towards very specific subcellular organelles. Even though the major subcellular target even today is nucleus, there is growing body of evidence that other organelles also have role in many diseases (Davis et al., 2007). Targeting therapeutics to subcellular organelles would positively improve treatment in a myriad of diseases of metabolic, genetic and oncologic nature. Oncology is perhaps the most demanding area for organelle specific targeting since the standard therapy for oncology involves random interaction with cellular components and is harbinger of potential problems like toxicity and immunogenicity (Fulda et al., 2010; Galluzzi et al., 2008). Subcellular organelles in eukaryotic cells comprise of a complex organization of distinct membrane-bound compartments and these form the cellular basis of human physiology. These subcellular organelles by virtue of highly specialized metabolic functions interact with each other to uphold various cellular functions. Organelle biogenesis regulated by transcriptional networks modulating expression of genes encoding organellar proteins results in inheritance and proliferation of subcellular organelles such as nucleus, mitochondria, endoplasmic reticulum, peroxisomes and lysosomes (Hill et al., 1995; Nunnari et al., 1996; Warren et al., 1996). The recent developments in molecular and cellular biology opened up new vistas in the development of metabolic disorders due to disruption of organelle biogenesis. The disorders pertaining to organelles are not limited to genetic and metabolic origin. They are also involved in metabolic disturbances occurred during diseases due to infections, intoxications and drug treatments (Dhaunsi, 2005). The subcellular organelles are involved in wide array of diseases known to human nature like myopathy, obesity, type 2 diabetes, Zellweger syndrome, cancer etc., and these diseases are explained in detail further in the review. Thus, appropriate targeting of subcellular organelles not only
Polar order of an achiral taper-shaped liquid crystal in the uniaxial smectic A phase (2018)

Coupling of a taper-shaped structure and phenylpyrimidine–cyanobiphenyl interaction organizes a polar order parallel to the layer normal in the SmA phase.
<title>Algorithm to choose which pixels to zero out in a zero and phase filter</title> (1993)

An algorithm to choose which pixels to zero out in an otherwise phase-only filter is presented. This algorithm involves a simple thresholding technique applied to the general spatial filter described in previous work. Having fixed those pixels which are to be set equal to 0 in the filter, one can then view the remaining phases as free parameters and design a good 0 and continuous phase filter by optimizing the filter's signal-to-clutter ratio using the author's techniques. One can the discretize this zero and phase filter into one whose entries are 0 or one of the nth roots of unity. For example, ternary (0, +1, and -1) filter are of this form as are filters whose entries are 0 and the sixteenth roots of unity. Examples of such are given. This paper together with its ancestor provides a completely automatic way to start with a training set of true and false targets of any size and automatically and without human intervention produce optimized filters for use in extant spatial light modulators.
[Surgical correction of congenital arteriovenous aneurysms of the lungs]. (1988)

The authors have analyzed results of the surgical treatment of 24 out of 26 patients observed at the clinic for arterio-venous aneurysms of the lungs. It was found that the reduction of efficiency of the gas exchange function of the lungs before operation manifested itself by arterial and venous hypoxemia with an increased arterio-venous oxygen difference and pronounced decrease of blood oxygen strain. Good results of the operative treatment, rapid recovery of blood oxygenation, disappearance of hypoxemia symptoms make the surgical method the only radical one in treatment of such patients. The operation of choice was lobectomy. No lethal outcomes followed.
Electrical Submersible Pump Performance Using Variable Speed Drives (1985)

ABSTRACT Variable speed drive units (VSD) designed specifically for use with electrical submersible pumps (ESP) have been available for several years. The ability to vary the operating speed of the ESP greatly expands the operating range of the unit. To take full advantage of the capabilities of an ESP operating on a VSD, it is necessary to understand the concepts of sizing and the operational limitations of the equipment.
Chlordiazepoxide attenuates activity-induced anorexia and weight loss in rats. (1998)

In Experiment 1, the effect of repeated injections of 2.5, 5.0, or 10.0 mg/kg of chlordiazepoxide (CDP) on food intake and body weight was studied in rats on an activity anorexia (AA) regimen. For several days before CDP testing began, rats lived in activity wheels and had one 60-min meal per day. During CDP testing, this regimen continued except that each rat was injected with an appropriate dose of CDP or saline 30 min before each meal. CDP enhanced food intake; 5.0 mg/kg seemed most effective. However, the CDP-induced increase in eating did not noticeably stem weight loss. In Experiment 2, after several days of AA training, CDP (5.0 mg/kg) was tested under less severe conditions; food remained restricted, but access to the wheels was discontinued. Rats given CDP ate more and gained more weight than controls. These findings suggest that benzodiazepines such as CDP may help in treating anorexia nervosa and other anorectic conditions in humans.
High-speed digital design: a handbook of black magic (1993)

Fundamentals high speed properties of logic gates measurement techniques transmission lines ground planes and layer stacking terminations VIAS power systems connectors ribbon cables clock distribution clock oscillators.
ChemInform Abstract: Microstructure of Epitaxial Ferroelectric YBa2Cu3O7‐x/Pb0.9La0.1(Zr0. 2Ti0.8)0.975O3/YBa2Cu3O7‐x (YBCO/PLZT/YBCO) Heterostructures on LaAlO3. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Thyromimetics. II. The Synthesis and Hypocholesteremic Activity of Some β-Diethylaminoethyl Esters of Iodinated Thyroalkanoic Acids (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThyromimetics. II. The Synthesis and Hypocholesteremic Activity of Some β-Diethylaminoethyl Esters of Iodinated Thyroalkanoic AcidsBenjamin Blank, Francis R. Pfeiffer, Cyrus M. Greenberg, and James F. KerwinCite this: J. Med. Chem. 1963, 6, 5, 560–563Publication Date (Print):September 1, 1963Publication History Published online1 May 2002Published inissue 1 September 1963https://pubs.acs.org/doi/10.1021/jm00341a021https://doi.org/10.1021/jm00341a021research-articleACS PublicationsRequest reuse permissionsArticle Views42Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Deep Sequence Learning for Accurate Gestational Age Estimation from a\n $\\$$25 Doppler Device (2020)

Assessing fetal development is usually carried out by techniques such as\nultrasound imaging, which is generally unavailable in rural areas due to the\nhigh cost, maintenance, skills and training needed to operate the devices\neffectively. In this work, we propose a low-cost one-dimensional Doppler-based\nmethod for estimating gestational age (GA). Doppler time series were collected\nfrom 401 pregnancies between 5 and 9 months GA using a smartphone. The proposed\nmodel for GA estimation is based on sequence learning by forming a temporally\ndependent model using a convolutional long-short-term memory network.\nTime-frequency features are extracted from Doppler signals and regularized\nbefore feeding to the network. The overall mean absolute GA error with respect\nto the last menstrual period was found to be 0.71 month, which outperforms all\nprevious works.\n
DDEL-07. A PHASE I STUDY EXAMINING THE FEASIBILITY OF INTERMITTENT CONVECTION-ENHANCED DELIVERY (CED) OF MTX110 FOR THE TREATMENT OF CHILDREN WITH NEWLY DIAGNOSED DIFFUSE MIDLINE GLIOMAS (2020)

Abstract Convection-enhanced delivery (CED, the infusion of drugs under controlled pressure to the brain parenchyma via targeted micro-catheters, allows accurate anatomical targeting and delivery of higher (therapeutic) drug concentrations through clinically relevant volumes of brain tissue or tumor. Histone deacetylase inhibitors have been found in vitro to be the most active agents against Diffuse Midline Gliomas (DMGs) Using a novel device (implantable subcutaneous pump connected with catheter directly implanted into the pons/thalamus) we are performing a Phase I safety study of repeated infusions of MTX110 (MTX110, Midatech) in a dose escalation manner. Eligible patients include 3–18 years of age with newly diagnosed DMGs following radiation therapy without evidence of hemorrhage or cysts with intact organ function. Patients undergo a tumor biopsy and a single catheter (Spetzler lumbar shunt catheter, Integra, Plainsboro, NJ) is placed stereotactically into the geometric center of the tumor. A second catheter is inserted subcutaneously with the distal tubing connected to the infusion pump, (SynchroMed II (Medtronic)), also inserted subcutaneously. The infusion pump is prefilled with MTX110 and administered using wireless N’Vison Clinical programmer into two 24-hour infusions, consisting of 20 hours of drug infusions at 0.2mL/hr. The pulse is completed 7 days later. This is a dose escalation study with the infusate consisting of gadolinium and MTX110 (30, 60, or 90 microM). The study describing the first use in children of this device for direct-to-tumor drug delivery is open to recruitment (January 2020) and the preliminary data will be available for presentation by June 2020.
Optimization of Airfoil Blend Limits With As-Manufactured Geometry Finite Element Models (2020)

Abstract Conventional airfoil blend repair limits are established using nominal, design intent geometry. This convention does not explicitly consider the inherent blade-to-blade structural response variation associated with geometric manufacturing deviations. In this work, we explore whether accounting for these variations leads to significant differences in blend depths and develop a novel approach to effectively predict blade-specific blend allowables. These blade-specific values maximize the part repairability according to their proximity to defined structural integrity constraints. The methodology is demonstrated on the as-manufactured geometry of an aerodynamic research rig compressor rotor. Geometric point cloud data of this rotor is used to construct as-built finite element models (FEMs) of each airfoil. The effect of two large blends on these airfoils demonstrates the opportunity of blade-specific blend limits. A new approach to determine each airfoil’s blend repair capacity is developed that uses sequential least squares quadratic programming and a parametric blended blade FEM that accounts for manufacturing geometry variations and variable blend geometry. A mesh morphing algorithm modifies a nominal geometry model to match the as-built airfoil surface and blend geometry. The numerical optimization maximizes blend depth values within frequency, mode shape, and high cycle fatigue (HCF) constraint boundaries. It is found that there are large variations in blend depth allowables between blades and competing structural integrity criteria are responsible for their limits. It is also found that, despite complex modal behavior caused by eigenvalue veering, the proposed optimization approach converges. The developed methodologies may be used in the future to extend blend limits, enable continued operations, and reduce sustainment costs.
Efficient delivery of micro RNA to bone-metastatic prostate tumors by using aptamer-conjugated atelocollagen in vitro and in vivo (2014)

Bone is the primary site of skeletal metastasis in prostate cancer (PCa). Atelocollagen (ATE)-mediated siRNA delivery system can be used to silence endogenous genes involved in PCa metastatic tumor cell growth. However, we hope that the delivery system can target PCa cells to reduce damage to the bone tissue and improve the therapeutic effect. RNA aptamer (APT) A10-3.2 has been used as a ligand to target PCa cells that express prostate-specific membrane antigen (PSMA). APT was investigated as a PSMA-targeting ligand in the design of an ATE-based microRNA (miRNA; miR-15a and miR-16-1) vector to PCa bone metastasis. To observe the targeted delivery and transfection efficiency of ATE-APT in PSMA-overexpressing cells, luciferase activity and biodistribution of nanoparticles in Balb/c mice was analyzed. The anticancer effect of nanoparticles in vivo was investigated using the survival times of human PCa bone metastasis mice model. Luciferase assays of pGL-3 expression against PC3 (PSMA(-)) and LNCaP (PSMA(+)) cells showed that the transfection efficiency of the synthesized DNA/ATE-APT complex was higher than that of the DNA/ATE complex. The anticancer efficacy of miRNA/ATE-APT was superior to those of other treatments in vivo. This PSMA-targeted system may prove useful in widening the therapeutic window and allow for selective killing of PCa cells in bone metastatic foci.
Identification of Previously Unrecognized Antiestrogenic Chemicals Using a Novel Virtual Screening Approach (2006)

The physiological roles of estrogen in sexual differentiation and development, female and male reproductive processes, and bone health are complex and diverse. Numerous natural and synthetic chemical compounds, commonly known as endocrine disrupting chemicals (EDCs), have been shown to alter the physiological effects of estrogen in humans and wildlife. As such, these EDCs may cause unanticipated and even undesirable effects. Large-scale in vitro and in vivo screening of chemicals to assess their estrogenic activity would demand a prodigious investment of time, labor, and money and would require animal testing on an unprecedented scale. Approaches in silico are increasingly recognized as playing a vital role in screening and prioritizing chemicals to extend limited resources available for experimental testing. Here, we evaluated a multistep procedure that is suitable for in silico (virtual) screening of large chemical databases to identify compounds exhibiting estrogenic activity. This procedure incorporates Shape Signatures, a novel computational tool that rapidly compares molecules on the basis of similarity in shape, polarity, and other bio-relevant properties. Using 4-hydroxy tamoxifen (4-OH TAM) and diethylstilbestrol (DES) as input queries, we employed this scheme to search a sample database of approximately 200,000 commercially available organic chemicals for matches (hits). Of the eight compounds identified computationally as potentially (anti)estrogenic, biological evaluation confirmed two as heretofore unknown estrogen antagonists. Subsequent radioligand binding assays confirmed that two of these three compounds exhibit antiestrogenic activities comparable to 4-OH TAM. Molecular modeling studies of these ligands docked inside the binding pocket of estrogen receptor alpha (ERalpha) elucidated key ligand-receptor interactions that corroborate these experimental findings. The present study demonstrates the utility of our computational scheme for this and related applications in drug discovery, predictive toxicology, and virtual screening.
Review of the New Delayed‐Release Oral Tablet and Intravenous Dosage Forms of Posaconazole (2015)

The triazole antifungal posaconazole was first approved as an oral suspension formulation. Despite pharmacokinetic target attainment and clinical efficacy in premarketing trials, postmarketing analyses indicated unpredictable bioavailability resulting in subtherapeutic concentrations and reports of breakthrough fungal infections. The newly approved posaconazole delayed-release tablet and intravenous formulations display more consistent bioavailability in the presence of concomitant disease states, medications, and dietary considerations that classically alter drug concentrations of the oral suspension. Both the delayed-release tablet and intravenous formulation display a similar adverse-effect profile to the oral suspension. The posaconazole delayed-release oral tablet is not significantly affected by gastric acid suppression therapy, and the intravenous dosage form provides an option for patients who are intubated or unable to tolerate oral medications. Pharmacoeconomic considerations, particularly with intravenous posaconazole, will likely play a role in dosage form selection and frequency of use. Due to sustained, higher drug concentrations, the new posaconazole formulations hold promise for greater efficacy in antifungal prophylaxis and bring opportunity for further study in the treatment of invasive mycoses.
CT-GUIDED BIOPSY OF METASTATIC SACRAL TUMORS (1990)

Between June 8, 1985 and January 29, 1986, the authors performed five CT-guided needle biopsies of suspicious sacral lesions. In each of the five cases, these biopsies allowed the acquisition of specimens suitable for definitive pathologic diagnosis. Three cases of metastatic adenocarcinoma, one case of desmoplastic fibroma, and one case of chronic inflammatory changes were noted. In the case involving chronic inflammatory changes, subsequent open biopsy was performed, confirming the inflammatory changes and absence of neoplasm. The authors conclude that percutaneous CT-guided biopsy of sacral lesion can be performed safely and rapidly, and allows accurate diagnosis and treatment of sacral lesions.
Outbreak of tuberculosis caused by Mycobacterium bovis in golden Guernsey goats in Great Britain (2009)

An outbreak of caprine tuberculosis caused by Mycobacterium bovis was disclosed in June 2008, affecting goats of the golden Guernsey breed kept on 10 separate smallholdings in south-west Wales and the west of England. Following the initial diagnosis at postmortem examination, 30 goats that reacted positively to the single intradermal comparative cervical tuberculin (SICCT) test, together with five in-contact animals, were euthanased and subjected to postmortem examination and mycobacterial culture. Spoligotyping and variable number tandem repeat analysis of isolates showed that they were all of the same genotype, endemic to south-west Wales. Retrospective movement tracings identified a goat herd in south-west Wales, by then completely dispersed, as the probable common source of infection. There was a perfect correlation between the SICCT test and culture results in all slaughtered goats. Grossly visible tubercular lesions were observed at postmortem examination in all but one reactor.
Persistent Interexcitonic Quantum Coherence in CdSe Quantum Dots (2013)

The creation and manipulation of quantum superpositions is a fundamental goal for the development of materials with novel optoelectronic properties. In this letter, we report persistent (~80 fs lifetime) quantum coherence between the 1S and 1P excitonic states in zinc-blende colloidal CdSe quantum dots at room temperature, measured using Two-Dimensional Electronic Spectroscopy. We demonstrate that this quantum coherence manifests as an intradot phenomenon, the frequency of which depends on the size of the dot excited within the ensemble of QDs. We model the lifetime of the coherence and demonstrate that correlated interexcitonic fluctuations preserve relative phase between excitonic states. These observations suggest an avenue for engineering long-lived interexcitonic quantum coherence in colloidal quantum dots.
Generation of 1D4 Single Chain Fv-Fc (2011)

Immunotherapeutic approaches using agonist antibodies or fusion proteins of immunomodulatory molecules significantly inhibit tumor growth and boost cell-mediated immunity. We isolated mRNA from previously reported 1D4 hybridoma cells and amplified the variable regions of the heavy chain (VH) and light chain (VL) genes using reverse-transcriptase polymerase chain reaction. Using a linker, the amplified sequences for the heavy and light chains were each connected to the sequence for a single polypeptide chain that was designed to be expressed. The VL and VH fragments were cloned into the pOptiVEC-TOPO vector that contained the human CH2-CH3 fragment. Then, 293T cells were transfected with the 1D4 single-chain Fv-Fc (scFv-Fc) constructs. A549 cells were used to present the 1D4 antigen. The secreted 1D4 scFv-Fc constructs were analyzed by flow cytometry. The DNA sequence of 1D4 scFv-Fc was obtained. The 1D4 scFv-Fc constructs were expressed by the transfected 293T cells and secreted into the culture medium. The immunoreactivity of the secreted scFv-Fc construct was lower than the murine 1D4 antibody for A549 cells. A 1D4 scFv-Fc construct for immunotherapy was developed.
SMARTVIDEO. SMARTIZATION AND LAYERED LEARNING VIDEOS (2017)

Appears in: INTED2017 Proceedings Publication year: 2017Pages: 8991-8995ISBN: 978-84-617-8491-2ISSN: 2340-1079doi: 10.21125/inted.2017.2123Conference name: 11th International Technology, Education and Development ConferenceDates: 6-8 March, 2017Location: Valencia, Spain