gebhart/patrepeval huggingface dataset:
An alternative approach to defining the role of the clinical teacher (1994)

BACKGROUND. A number of studies have attempted to identify the components of the clinical teacher role by examining learners' numerical ratings of items on researcher-generated lists. Some of these studies have also compared different groups' perceptions of clinical teaching, but have not directly compared the perceptions of first- and third-year residents. This study addressed two questions: (1) What do residents consider important components of the clinical teacher role? (2) Do first- and third-year residents perceive this role similarly? METHOD. A content analysis was performed on the comments written on evaluation forms by 268 residents about 490 clinical teachers over a five-year period (1980–81 through 1984–85) at a large family practice residency. Of 5,664 forms completed by the residents, 2,388 (42%) contained written comments; comments were on 1,024 (46%) of the first-year resident's forms, 701 (41%) of the second-year residents' forms, and 663 (39%) of the third-year residents' forms. Themes in these comments were coded into a coding dictionary of 157 categories, within 37 clusters, within four roles. RESULTS. The ten highest-ranked categories (Global; Teaching: General; Knowledgeable; Gives Resident Responsibility; Supportive; Miscellaneous; Interested in Teaching; Clinical Competence; Makes Effort to Teach; and Gives Resident Opportunity to Do Procedures) accounted for 41% of the themes coded. The first- and third-year residents differed in the clusters they used to describe their clinical teachers on evaluation forms (chi 2 = 149.86, df = 36, p &lt; .0001). CONCLUSION. The results suggest that content analysis can be used to validly and reliably study residents' written evaluative comments about their teachers. This study contributes to the definition of the clinical teacher role, showing the relative importances of its components, and also supports Stritter's Learning Vector theory, finding the anticipated differences between the comments made by first- and third-year residents.
Synthesis of heat-shock proteins in liver and in hepatomas of different growth rates (1986)

Conference Article| October 01 1986 Synthesis of heat-shock proteins in liver and in hepatomas of different growth rates L. BARDELLA; L. BARDELLA 1Institute di Patologia Generale, Centro di Studio sulla Patologia Cellulare del C.N.R., Via Mangiagalli 31, 20133, Milano, Italy Search for other works by this author on: This Site PubMed Google Scholar L. SCHIAFFONATI; L. SCHIAFFONATI 1Institute di Patologia Generale, Centro di Studio sulla Patologia Cellulare del C.N.R., Via Mangiagalli 31, 20133, Milano, Italy Search for other works by this author on: This Site PubMed Google Scholar G. CAIRO; G. CAIRO 1Institute di Patologia Generale, Centro di Studio sulla Patologia Cellulare del C.N.R., Via Mangiagalli 31, 20133, Milano, Italy Search for other works by this author on: This Site PubMed Google Scholar A. BERNELLI-ZAZZERA A. BERNELLI-ZAZZERA 1Institute di Patologia Generale, Centro di Studio sulla Patologia Cellulare del C.N.R., Via Mangiagalli 31, 20133, Milano, Italy Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: April 04 1986 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1986 Biochemical Society1986 Biochem Soc Trans (1986) 14 (5): 974–975. https://doi.org/10.1042/bst0140974 Article history Received: April 04 1986 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation L. BARDELLA, L. SCHIAFFONATI, G. CAIRO, A. BERNELLI-ZAZZERA; Synthesis of heat-shock proteins in liver and in hepatomas of different growth rates. Biochem Soc Trans 1 October 1986; 14 (5): 974–975. doi: https://doi.org/10.1042/bst0140974 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: hsp(s), heat-shock protein(s) This content is only available as a PDF. © 1986 Biochemical Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.
Low fibrosis progression of recurrent hepatitis C in apolipoprotein E ɛ4 carriers: relationship with the blood lipid profile (2005)

Recipient's carriage of ApoE epsilon4 affects fibrosis progression of recurrent hepatitis C through gender-specific mechanisms, associated with a peculiar, ApoE-associated, lipid profile.
Alkyl nitrate measurements during STERAO 1996 and NARE 1997: Intercomparison and survey of results (2001)

Alkyl nitrates were measured over the northeastern plains of Colorado during the Stratospheric Tropospheric Exchange: Radiation, Aerosols and Ozone (STERAO) 1996 campaign and over the North Atlantic during the North Atlantic Regional Experiment (NARE) 1997. Alkyl nitrate measurements were performed by two different laboratories enabling an intercomparison of analytical techniques. A weighted bivariate linear regression analysis of comparable samples (National Oceanic and Atmospheric Administration versus National Center for Atmospheric Research) for the four alkyl nitrates measured by both techniques (2‐propyl nitrate, 1‐propyl nitrate, 2‐butyl nitrate, and 3‐pentyl nitrate) suggests there is neither a significant calibration difference nor a systematic offset. The precision of the measurements is indicated by the scatter in the correlations. Good precision is observed for the 2‐butyl nitrate measurements (square of the correlation coefficient, R 2 = 0.90). However, relatively small values of R 2 and relatively large uncertainties in the determination of the slopes and intercepts (2σ confidence intervals) for 2‐propyl nitrate, 1‐propyl nitrate, and 3‐pentyl nitrate suggest significant imprecision when compared to ambient mixing ratios for at least one of the measurement techniques. Vertical profiles during NARE 1997 show high levels of alkyl nitrates in well‐defined photochemical pollution layers of continental origin. A comparison of alkyl nitrate to hydrocarbon ratios with a sequential reaction scheme model suggests our understanding of C 4 –C 5 alkyl nitrate photochemistry is adequate to reproduce the observations. Air masses with larger ratios of alkyl nitrate to hydrocarbons were observed during NARE 1997 than STERAO 1996, consistent with the NARE 1997 measurements being in the more remote North Atlantic. These results suggest that information related to the photochemical age of an air mass can be derived from alkyl nitrate to hydrocarbon ratios.
Polyurethane Membranes Modified with Isopropyl Myristate as a Potential Candidate for Encapsulating Electronic Implants: A Study of Biocompatibility and Water Permeability (2010)

Medical polyurethanes have shown good bio-stability and mechanical properties and have been used as coating for implantable medical devices. However, despite their excellent properties, they are relatively permeable to liquid water and water vapour which is a drawback for electronic implant encapsulation. In this study polyether polyurethanes with different soft segment molecular weights were modified by incorporating isopropyl myristate (IPM), as a hydrophobic modifying agent, and the effect of IPM on water resistant and biocompatibility of membranes were investigated. IPM changed the surface properties of the polyurethane film and reduced its surface energy. Polyurethane films were found to be stable with IPM concentrations of 1–5 wt% based upon their chemistry; however it leached out in BSA at higher concentrations. Though, low concentrations of IPM reduced both liquid water and water vapour permeability; at higher IPM content liquid permeability did not improved significantly. In general, the polyurethane materials showed much lower water permeability compared with currently used silicone packaging material for electronic implants. In addition, cytotoxicity assessment of IPM containing polyurethanes showed no evidence of cytotoxcity up to 5 wt% IPM.
Comparison of Surgical Outcomes of Anterior and Posterior Fusion Surgeries for K-line (−) Cervical Ossification of the Posterior Longitudinal Ligament (2023)

Clinical improvement was comparable between anterior and posterior fusion surgeries for patients with K-line (-) OPLL. The ideal surgical approach should be informed based on the balance between the surgeon's technical preference and the risk of complications.
Segmentation-based modeling for advanced targeted marketing (2001)

Fingerhut Business Intelligence (BI) has a long and successful history of building statistical models to predict consumer behavior. The models constructed are typically segmentation-based models in which the target audience is split into subpopulations (i.e., customer segments) and individually tailored statistical models are then developed for each segment. Such models are commonly employed in the direct-mail industry; however, segmentation is often performed on an ad-hoc basis without directly considering how segmentation affects the accuracy of the resulting segment models. Fingerhut BI approached IBM Research with the problem of how to build segmentation-based models more effectively so as to maximize predictive accuracy. The IBM Advanced Targeted Marketing-Single EventsTM (IBM ATM-SETM) solution is the result of IBM Research and Fingerhut BI directing their efforts jointly towards solving this problem. This paper presents an evaluation of ATM-SE's modeling capabilities using data from Fingerhut's catalog mailings.
TRANSPORTATION COSTS IN ECONOMETRIC MODELS OF STATE AGRICULTURAL SECTORS: THE CASE OF BEEF IN HAWAII (1985)

Econometric models designed to show how national policies affect state agricultural sectors often use national prices as proxies for state prices. Consequently, they ignore the influence of freight rates on state production. An application to the Hawaii beef industry demonstrates that both freight rates and national beef prices have important impacts on Hawaii beef prices and production. By using state prices rather than national prices, error from changes in freight rates might be reduced, and the model's capacity for policy analysis might be broadened.
Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas (2016)

The present findings indicate that CA II and CA XII could be useful in predicting survival in CRC.
High-power fiber optic cable with integrated active sensors for live process monitoring (2012)

In industrial applications using high-brilliance lasers at power levels up to and exceeding 20 kW and similarly direct diode lasers of 10 kW, there is an increasing demand to continuously monitor component status even in passive components such as fiber-optic cables. With fiber-optic cables designed according to the European Automotive Industry fiber standard interface there is room for integrating active sensors inside the connectors. In this paper we present the integrated active sensors in the new Optoskand QD fiber-optic cable designed to handle extreme levels of power losses, and how these sensors can be employed in industrial manufacturing. The sensors include photo diodes for detection of scattered light inside the fiber connector, absolute temperature of the fiber connector, difference in temperature of incoming and outgoing cooling water, and humidity measurement inside the fiber connector. All these sensors are connected to the fiber interlock system, where interlock break enable functions can be activated when measured signals are higher than threshold levels. It is a very fast interlock break system as the control of the signals is integrated in the electronics inside the fiber connector. Also, since all signals can be logged it is possible to evaluate what happened inside the connector before the interlock break instance. The communication to the fiber-optic connectors is via a CAN interface. Thus it is straightforward to develop the existing laser host control to also control the CAN-messages from the QD sensors.
An Active Image-Based Mobile Food Record Is Feasible for Capturing Eating Occasions among Infants Ages 3–12 Months Old in Hawai‘i (2022)

The ability to comprehensively assess the diet of infants is essential for monitoring adequate growth; however, it is challenging to assess dietary intake with a high level of accuracy. Infants rely on surrogate reporting by caregivers. This study aimed to determine if surrogate reporters (e.g., caregivers) could use an image-based mobile food record adapted (baby mFR) to record infants' eating occasions, and via caregiver feedback, could assess the usability and feasibility of the baby mFR in recording infants' diets. This was a cross-sectional study in which surrogate reporters (e.g., caregivers) recorded all food and beverage intake (including human milk) of the infant over a 4-day period. Trained research staff evaluated all images submitted during data collection for different indicators of quality. All surrogate reporters were asked to complete a usability questionnaire at the end of the 4-day data collection period. Basic descriptive analyses were performed on the infants 3-12 months of age (<i>n</i> = 70). A total of 91% (<i>n</i> = 64) of surrogate reporters used the baby mFR to record their infants' eating occasions. The mean number of images submitted daily per participant via the mFR was 4.2 (SD 0.2). A majority of submitted images contained the fiducial marker and the food and/or beverage was completely visible. The mFR was found to be easy to use; however, suggestions were provided to increase utility of the application such as the inclusion of a bottle button and reminders. An image-based dietary assessment method using a mobile app was found to be feasible for surrogate reporters to record an infant's food and beverage intake throughout the day.
Normalisation of urinary biomarkers to creatinine for clinical practice and research – when and why (2015)

Acute kidney injury (AKI) and chronic kidney disease (CKD) are major health problems. Urinary biomarkers have both diagnostic and prognostic utility in AKI and CKD. However, how biomarker excretion rates should be reported, especially whether they should be normalised to urinary creatinine concentration (uCr), is controversial. Some studies suggest that normalisation to uCr may be inappropriate at times, as urinary creatinine excretion rate may vary greatly, depending on the situation. Notably, recent studies suggest that while normalisation of values to UCr may be valid for the evaluation of CKD and prediction of AKI sequelae and occurrences, it could be inappropriate for the diagnosis of AKI, or in the presence of certain acute kidney disease states.
[Control of gene expression by antisense nucleic acids]. (1992)

The use of antisense RNA or of antisense oligonucleotides for the specific control of viral or cellular genes expression has undergone rapid developments recently; their respective advantages and drawbacks will be discussed. Progresses in oligonucleotides chemistry have lead to the synthesis of analogs with improved pharmacological properties. Besides the antisense approach, which usually targets translation initiation or splicing sites, it is possible to interfere specifically with gene expression through triple helix formation (anti-gene strategy) or through the titration of regulatory proteins (sense approach). A major problem encountered in the use of synthetic oligonucleotides is their delivery to their nuclear or cytoplasmic targets after cell uptake by an endocytic pathway; our own work in this field will be discussed. Finally, we will describe the strategies followed by our group to improve the bioavailability of antisense oligonucleotides, as for instance conjugation to poly (L-lysine) or encapsidation in antibody-targeted liposomes.
Isolation of Isocoumarins and Flavonoids as α-Glucosidase Inhibitors from Agrimonia pilosa L. (2020)

<i>Agrimonia pilosa</i> L. (AP) showed potent α-glucosidase inhibitory (AGI) activity, but it is uncertain what phytochemicals play a key factor. The phytochemical study of AP based on AGI activity led to the isolation of four isocoumarins; agrimonolide (<b>1</b>), agrimonolide-6-<i>O</i>-β-d-glucopyranoside (<b>2</b>), desmethylagrimonolide (<b>3</b>), desmethylagrimonolide-6-<i>O</i>-β-d-glucopyranoside (<b>4</b>), and four flavonoids; luteolin (<b>5</b>), quercetin (<b>6</b>), vitexin (<b>7</b>), and isovitexin (<b>8</b>). The four isocoumarins were isolated as α-glucosidase inhibitors for the first time. Isocoumarins, compound 1 (agrimonolide) and 3 (desmethylagrimonolide) showed strong α-glucosidase inhibitory activities with IC<sub>50</sub> values of 24.2 and 37.4 µM, respectively. Meanwhile, isocoumarin and flavonoid glycosides showed weak AGI activity. In the kinetic analysis, isocoumarins, compounds 1 and 3 showed non-competitive inhibition, whereas flavonoid, compound <b>6</b> showed competitive inhibition.
Summary Report on Worldwide Antibiotic Resistance: International Task Forces on Antibiotic Use (1985)

Journal Article Summary Report on Worldwide Antibiotic Resistance: International Task Forces on Antibiotic Use Get access John P. Burke, John P. Burke Fogarty International Center, National Institutes of HealthBethesda, MarylandDepartment of Molecular Biology and Microbiology, School of Medicine, Tufts UniversityBoston, Massachusetts Please address requests for reprints to Dr. John P. Burke, International Studies Branch, Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20205. Search for other works by this author on: Oxford Academic PubMed Google Scholar Stuart B. Levy Stuart B. Levy Fogarty International Center, National Institutes of HealthBethesda, MarylandDepartment of Molecular Biology and Microbiology, School of Medicine, Tufts UniversityBoston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar Reviews of Infectious Diseases, Volume 7, Issue 4, July 1985, Pages 560–564, https://doi.org/10.1093/clinids/7.4.560 Published: 01 July 1985 Article history Received: 05 April 1985 Published: 01 July 1985
Inhibition ofendosome fusion byphospholipase A2(PLA2) inhibitors points toaroleforPLA2inendocytosis LuisS.MAYORGA*t, MARiAI.COLOMBO*t, MICHELLELENNARTZ*, ERicJ.BROWNS,K.HAYATRAHMAN§, (1993)

Fusion ofintracellular membrane-bound compartments isacommonstep inthetransport ofmacromol- ecules along theendocytic andsecretory pathways. A large number offactors active inthefusion process orits regulation havebeenidentified; however, theactual sequence ofevents leading tomembrane fusion isstill unknown. Inthis study, we haveassessed apossible role forPLA2inendosome fusion by using aninvitro reconstitution assay andbyexamining en- docytosis inintact cells. Several PLA2inhibitors blocked endosome fusion inabroken-cell preparation. Inhibition was reversed byaddition ofarachidonic acid. Attheelectron microscope level, endosome clusters wereobserved eveninthe presence ofinhibitors; however, actual fusion between endo- somes waslargely reduced. Fusion frequency increased upon theaddition ofarachidonic acid. A membrane-permeable PLA2inhibitor blocked mixing ofligands internalized sequen- tially butdidnotaffect internalization. Theresults indicate that vesicle fusion along theendocytic pathway requires aPLA2 activity. Theeffect ofthis activity wouldbe,atleast inpart, mediated byarachidonic acid release. Transport ofmacromolecules along theendocytic andsecre- torypathways requires aseries ofhighly coordinated and specific membrane fusion events involving multiple cytosolic andmembrane factors (1-3). Membrane fusion events medi- ating intracellular transport share several commonproperties (2,4).Manystepsrequire N-ethylmaleimide (NEM)- sensitive factor (NSF), aprotein that binds tomembrane in thepresence ofsoluble NSFattachment proteins, andmem- brane-associated NSFreceptors (5). GTP-binding proteins of theARF(6, 7), rab(8-10), andheterotrimeric (11, 12)families arealso part ofthefusion machinery. Inaddition, amem- brane-bound trypsin-sensitiv e
Mechanism of Reoxygenation after Antiangiogenic Therapy Using SU5416 and Its Importance for Guiding Combined Antitumor Therapy (2006)

Emerging preclinical studies support the concept of a transient "normalization" of tumor vasculature during the early stage of antiangiogenic treatment, with possible beneficial effects on associated radiotherapy or chemotherapy. One key issue in this area of research is to determine whether this feature is common to all antiangiogenic drugs and whether the phenomenon occurs in all types of tumors. In the present study, we characterized the evolution of the tumor oxygenation (in transplantable liver tumor and FSAII tumor models) after administration of SU5416, an antagonist of the vascular endothelial growth factor receptor. SU5416 induced an early increase in tumor oxygenation [measured by electronic paramagnetic resonance (EPR)], which did not correlate with remodeling of the tumor vasculature (assessed by CD31 labeling using immunohistochemistry) or with tumor perfusion (measured by dynamic contrast enhanced-magnetic resonance imaging). Inhibition of mitochondrial respiration (measured by EPR) was responsible for this early reoxygenation. Consistent with these unique findings in the tumor microenvironment, we found that SU5416 potentiated tumor response to radiotherapy but not to chemotherapy. In addition to the fact that the characterization of the tumor oxygenation is essential to enable correct application of combined therapies, our results show that the long-term inhibition of oxygen consumption is a potential novel target in this class of compounds.
Deep Structure for end-to-end inverse rendering (2017)

Inverse rendering in a 3D format denoted to recovering the 3D properties of a scene given 2D input image(s) and is typically done using 3D Morphable Model (3DMM) based methods from single view images. These models formulate each face as a weighted combination of some basis vectors extracted from the training data. In this paper a deep framework is proposed in which the coefficients and basis vectors are computed by training an autoencoder network and a Convolutional Neural Network (CNN) simultaneously. The idea is to find a common cause which can be mapped to both the 3D structure and corresponding 2D image using deep networks. The empirical results verify the power of deep framework in finding accurate 3D shapes of human faces from their corresponding 2D images on synthetic datasets of human faces.
Conservative Surgery With Radiation Therapy in Clinical Stage I and II Breast Cancer (1989)

Conservative surgery and radiation therapy have been increasingly utilized at Yale-New Haven (Conn) Hospital since the 1960s. This analysis represents our experience from 1962 to 1982, with a total of 281 patients having a minimum assessable follow-up of five years and a median follow-up of 7.4 years. Five- and ten-year actuarial survivals were 83% and 67%, respectively. The actuarial breast recurrence-free rate was 91% at five years and 80% at ten years. Of 31 patients having recurrences in the breast alone, the actuarial five-year survival following recurrence was 48%. Twenty-eight (90%) of these 31 recurrences were salvageable with mastectomy or repeated wedge resection. Patients experiencing an early breast recurrence (less than three years) following initial treatment had a poorer prognosis than patients having recurrences later.