gebhart/patrepeval huggingface dataset:
AVALIAÇÃO DE RISCO SOBRE A PERDA DE DUCTILIDADE A QUENTE DE BARRAS DE AÇO CA-50 (2017)

A capacidade de um determinado ao suportar as deformaes ocorridas durante laminao sem fraturas ou trincas severas denominada de ductilidade a quente, que funo de diversos parmetros de processo dentre os quais: qualidade do tarugo, tipo de corte, ciclo trmico, temperatura de processo, layout do laminador, calibrao, taxa de deformao e composio qumica. Diversos trabalhos abordam a ductilidade a quente enfatizando a influncia isolada de uma varivel como critrio de qualidade como as conhecidas relaes Mn/S e Ni/Cu atravs da determinao de valores mnimos. A globalizao tem sido responsvel pela crescente competitividade entre as siderrgicas que, para se manterem competitivas no mercado, tm que buscar inovaes, quebras de paradigmas, estratgias ousadas e assumir riscos. No presente trabalho realizou-se uma avaliao de risco com base no princpio ALARP (As Low As Reasonable Practical) atravs da anlise conjunta das principais variveis de processo responsveis pela perda de ductilidade a quente de um ao utilizado para
Loosely time-triggered architectures for cyber-physical systems (2010)

Cyber-Physical Systems require distributed architectures to support safety critical real-time control. Kopetz' Time-Triggered Architectures (TTA) have been proposed as both an architecture and a comprehensive paradigm for systems architecture, for such systems. To relax the strict requirements on synchronization imposed by TTA, Loosely Time-Triggered Architectures (LTTA) have been recently proposed. In LTTA, computation and communication units at all triggered by autonomous, non synchronized, clocks. Communication media act as shared memories between writers and readers and communication is non blocking. In this paper we review the different variants of LTTA and discuss their principles and usage.1
Intra- and extracerebral arachnoid cyst. An atypical roentgenographic presentation (1976)

Arachnoid cysts present in a variety of ways, and the preoperative diagnosis usually requires a high degree of suspicion. Bony changes consistent with a chronic focal mass effect, a relative paucity of clinical findings compared to the size of the lesion, and an extracerebral mass with an intracerebral component suggest the possibility. We present a case in which there appears to be a large, deep intracerebral mass associated with an extracerebral expansion.
Computational prediction of binding hotspots (2005)

We combine side-chain modeling, energy minimization and binding free energy calculation to predict point mutations with significant impacts on binding affinities (binding hotspots). Our method achieves high accuracy for two datasets (alanine-scanning mutations in ASEdb and 570 mutations on protease-inhibitor complexes). In particular, we can predict mutations that lead to improved binding with success. We discuss various factors that may contribute the prediction accuracy, including the amino acid to mutate to, and the position of the mutation.
Fine Needle-Diathermy Regresses Pathological Corneal (Lymph)Angiogenesis and Promotes High-Risk Corneal Transplant Survival (2018)

Pathological corneal hem- and lymphangiogenesis are prime risk factors for corneal graft rejection. Fine needle-diathermy (FND) is an option to regress corneal blood vessels; however, whether this treatment besides clinically visible blood vessels also affects invisible lymphatic vessels is so far unknown. Here we test the hypothesis that FND destroys not only blood but also lymphatic vessels, thereby promotes corneal high-risk graft survival. The effect of FND was studied in vivo using BALB/c mice and the model of suture-induced corneal neovascularization. Mice were divided into three groups: FND, ANTI (anti-inflammatory therapy) and NON (control). Five, 7, 10 and 20 days after cauterization, corneas were harvested and stained with LYVE-1, CD31 to quantify (lymph)angiogenesis. The long-term survival of allografts was compared between the three groups. FND caused significant regression of both blood and lymphatic vessels compared to the control group at all time points (p < 0.05) with the most obvious effect at day 7 (p < 0.01). Graft survival was significantly prolonged when transplants were placed into the FND pretreated group (p < 0.0001). The effect of the anti-inflammatory therapy alone was less effective compared to FND (p < 0.05). This novel lymphangioregressive effect of FND can be used clinically to precondition high-risk recipients to promote graft survival.
Sleep-Disordered Breathing in Patients with Symptomatic Heart Failure A Contemporary Study of Prevalence in and Characteristics of 700 Patients (2006)

This study confirms the high prevalence of SDB, particularly CSA in CHF patients. CSA seems to be a marker of heart failure severity.
Use of a lung model to assess mechanical in‐exsufflator therapy in infants with tracheostomy (2010)

Using the MIE via tracheostomy tube in an infant lung model, we found that an insufflation time of >1 sec is required for equilibration of insufflation pressure and alveolar pressure. Longer exsufflation time does not significantly alter MEF. Higher insufflation and exsufflation pressures both increased MEF, but greater exsufflation pressure had more substantial impact.
Towards true unipolar bio-potential recording: a preliminary result for ECG (2012)

We present a bio-potential front-end capable of recording unipolar ECG leads without making use of the Wilson central terminal (WCT). The information contained in the new unipolar recordings may yield unique diagnostic information as it avoids the need to essentially subtract data or make use of the averaging effect imposed by the WCT. The system also allows a direct, real-time software calculation of signals corresponding to standard ECG leads for standard diagnosis. These calculated standard ECG leads have a correlation in excess of 92% with a gold standard ECG recorded in parallel. The circuit is wideband, compatible with both the standard and the dry electrodes, and of low power (requiring less than 20 mW powered at 12 V). It is therefore well suited for long-term applications.
Effects of Micro/Nano-Scale Surface Characteristics on the Leidenfrost Point Temperature of Water (2012)

In recent film boiling heat transfer studies with nanofluids, it was reported that deposition of nanoparticles on a surface significantly increases the nominal minimum heat flux (MHF) or Leidenfrost Point (LFP) temperature, considerably accelerating the transient cooling of overheated objects. It was suggested that the thin nanoparticle deposition layer and the resulting changes in the physico-chemical characteristics of the hot surface, such as surface roughness height, wettability and porosity, could greatly affect quenching phenomena. In this study, a set of water-droplet LFP tests are conducted using custom-fabricated surfaces which systemically separate the effects of surface roughness height (0-15 um), wettability (0-83°) and nanoporosity (∼23 nm). In addition, high-speed imaging of the evaporating droplets is used to explore the influence of these surface characteristics on the intermittent solid-liquid contacts in film boiling. The obtained results reveal that nanoporosity (not solely high surface wettability) is the crucial feature in efficiently increasing the LFP temperature by initiating heterogeneous nucleation of bubbles during short-lived solid-liquid contacts, which results in disruption of the vapor film, and that micro-posts on the surface intensify such effects by promoting intermittent liquid-surface contacts.
High-Efficiency PFM Boost Converter With an Accurate Zero Current Detector (2017)

In this brief, an integrated pulse-frequency modulation boost converter with an accurate zero current detector (ZCD) is presented. The proposed ZCD is used to improve the power efficiency of the boost converter and comprises two hysteresis comparators, the transistors M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Z1</sub> -M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Z3</sub> , and a set-reset latch to eliminate the reverse current of the high-side switch in the energy release period. This ZCD can also avoid early or delayed detection and ensure stable operation in the discontinuous conduction mode. Furthermore, a new comparator incorporating an appropriate logic gate is developed to eliminate a constant current during the energy storage period. The proposed boost converter was designed and fabricated using the standard TSMC 0.18-μm 1P6M CMOS technology with a chip area of 0.43 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The experimental results revealed that the maximum power efficiency of 88.39% is achieved at a load current of 50 mA, and the lightload efficiency is enhanced by the proposed ZCD. Furthermore, power efficiency of the boost converter with the proposed ZCD is 28.29% higher than that of the existing ZCD design at a load current of 1 mA.
Induction patterns of 70 genes during nine days after hepatectomy define the temporal course of liver regeneration. (1993)

Liver regeneration is an important process that allows for recovery from hepatic injuries caused by viruses, toxins, ischemia, surgery, and transplantation. Previously, we identified > 70 immediate-early genes induced in regenerating liver after hepatectomy, 41 of which were novel. While it is expected that the proteins encoded by these genes may have important roles in regulating progression through the G1 phase of the cell cycle during regeneration, we were surprised to note that many of these "early" genes are expressed for extended periods during the hepatic growth response. Here we define several patterns of expression of immediate-early, delayed-early, and liver-specific genes during the 9-d period after hepatectomy. One pattern of induction parallels the major growth period of the liver that ends at 60-72 h after hepatectomy. A second pattern has two peaks coincident with the first and second G1 phases of the two hepatic cell cycles. A third group, which includes liver-specific genes such as C/EBP alpha, shows maximal expression after the growth period. Although the peak in DNA synthesis in nonparenchymal cells occur 24 h later than in hepatocytes, most of the genes studied demonstrate similar induction in both cell types. This finding suggests that the G0/G1 transition occurs simultaneously in all cells in the liver, but that the G1 phase of nonparenchymal cells may be relatively prolonged. Finally, we examined the expression of > 70 genes in clinical settings that could induce liver regeneration, including after perfusion in a donor liver, hepatic ischemia, and fulminant hepatic failure. We found that a small number of early and liver-specific genes were selectively activated in human livers under these conditions, and we thereby provide a potential means of measuring the caliber of the regenerative response in clinical situations.
Zero-aliasing space compaction of test responses using multiple parity signatures (1998)

We present a parity-based space compaction technique that eliminates aliasing for any given fault model. The test responses from a circuit under test with a large number of primary outputs are merged into a narrow signature stream using a multiple-output parity tree. The functions realized by the different outputs of the compactor are determined by a procedure that targets the desired fault model. Experimental results for the ISCAS-85 benchmarks show that zero aliasing of single stuck-line faults can be achieved with a two output parity tree compactor. Our findings corroborate recent results on the fundamental limits of space compaction.
A variable switching frequency algorithm to improve the total efficiency of single-phase grid-connected inverters (2013)

The selection of an optimal switching frequency of pulse width modulation (PWM) for single-phase inverters is one of the most effective ways to improve the inverters' efficiency. However, the lower switching frequency results in the higher harmonic voltage and current. For grid- connected inverters, the harmonic current distortion is significantly affected by the switching frequency. Therefore, the choice of switching frequency is usually considered as a tradeoff between lowering the total demand distortion (TDD) of output current and reducing the switching losses. In this paper, a variable switching frequency algorithm that changes the carrier frequency of a modified space vector pulse width modulation (SVPWM) control in real time based on different operating conditions is developed to improve the overall efficiency of the inverter while meeting a TDD requirement specified in IEEE Standard 1547. The performance of the proposed algorithm is verified by both Matlab-based simulation and experiments conducted on a 12kw single-phase inverter.
Overexpression of the Golgi‐localized enzyme α‐mannosidase IIx in Chinese hamster ovary cells results in the conversion of hexamannosyl‐N‐acetylchitobiose to tetramannosyl‐N‐acetylchitobiose in the N‐glycan‐processing pathway (2001)

Golgi alpha-mannosidase II is an enzyme that processes the intermediate oligosaccharide Gn(1)M(5)Gn(2) to Gn(1)M(3)Gn(2) during biosynthesis of N-glycans. Previously, we isolated a cDNA encoding a protein homologous to alpha-mannosidase II and designated it alpha-mannosidase IIx. Here, we show by immunocytochemistry that alpha-mannosidase IIx resides in the Golgi in HeLa cells. When coexpressed with alpha-mannosidase II, alpha-mannosidase IIx colocalizes with alpha-mannosidase II in COS cells. A protein A fusion of the catalytic domain of alpha-mannosidase IIx hydrolyzes a synthetic substrate, 4-umbelliferyl-alpha-D-mannoside, and this activity is inhibited by swainsonine. [(3)H]glucosamine-labeled Chinese hamster ovary cells overexpressing alpha-mannosidase IIx show a reduction of M(6)Gn(2) and an accumulation of M(4)Gn(2). Structural analysis identified M(4)Gn(2) to be Man alpha 1-->6(Man alpha 1-->2Man alpha 1-->3)Man beta 1-->4GlcNAc beta 1-->4GlcNAc. The results suggest that alpha-mannosidase IIx hydrolyzes two peripheral Man alpha 1-->6 and Man alpha 1-->3 residues from [(Man alpha 1-->6)(Man alpha 1-->3)Man alpha 1-->6](Man alpha 1-->2Man alpha 1-->3)Man beta 1-->4GlcNAc beta 1-->4GlcNAc, during N-glycan processing.
Antimonide-based Geiger-mode avalanche photodiodes for SWIR and MWIR photon counting (2010)

At MIT Lincoln Laboratory, avalanche photodiodes (APDs) have been developed for both 2-μm and 3.4-μm detection using
the antimonide material system. These bulk, lattice-matched detectors operate in Geiger mode at temperatures up to 160 K.
The 2-μm APDs use a separate-absorber-multiplier design with an InGaAsSb absorber and electron-initiated avalanching
in the multiplier. These APDs have exhibited normalized avalanche probability (product of avalanche probability and
photo-carrier-injection probability) of 0.4 and dark count rates of ~150 kHz at 77 K for a 30-μm-diameter device. A 1000-
element imaging array of the 2-μm detectors has been demonstrated, which operate in a 5 kg dewar with an integrated
Stirling-cycle cooler. The APD array is interfaced with a CMOS readout circuit, which provides photon time-of-arrival
information for each pixel, allowing the focal plane array to be used in a photon-counting laser radar system. The 3.4-μm
APDs use an InAsSb absorber and hole-initiated avalanching and have shown dark count rates of ~500 kHz at 77 K but
normalized avalanche probability of < 1%. Research is ongoing to determine the cause of the low avalanche probability
and improve the device performance.
Confined electron emission with femtosecond timing: nonlinearity, localization, enhancement (2010)

The local extraction of electrons from metal nanotips is an essential component of both scanning tunneling microscopes and transmission or scanning electron microscopes based on field emission cathodes. Laser-induced electron emission from sharp tip structures is a prerequisite for equipping such methods with ultrafast temporal resolution. In this paper, recent experiments on femtosecond electron emission from sharp gold tips are discussed. Based on far-field and near-field characterization, confined multiphoton electron emission from the apex is demonstrated. The effective nonlinearity can be tuned by the application of an additional static bias voltage.
What Corners Look Like (1971)

Work reported herein was conducted at the Artificial Intelligence Laboratory, a Massachusetts Institute of Technology research program supported by the Advanced Research Projects Agency of the Department of Defense and monitored by the Office of Naval Research under Contract Number N00014-70-A-0362-0002.
Reply to Cheng et al.: COVID-19 induces lower extent of cytokines, but damages vascular endothelium by IL-6 signaling (2021)

Microbial communities are found throughout the biosphere, from human guts to glaciers, from soil to activated sludge. Understanding the statistical properties of such diverse communities can pave the way to elucidate the common mechanisms ...Multiple ecological forces act together to shape the composition of microbial communities. Phyloecology approaches—which combine phylogenetic relationships between species with community ecology—have the potential to disentangle such forces but are often ...
Long-term tracking demonstrates effectiveness of a partnership-led training program to advance the careers of biomedical researchers from underrepresented groups (2019)

The demographic profile of the biomedical workforce in the U.S. does not reflect the population at large, raising concerns that there will be insufficient trained researchers in the future, and the scope of research interests will not be sufficiently broad. To diversify and expand the pool of researchers trained to conduct research on cancer and cancer health disparities, a series of training activities to recruit and train primarily Hispanic students at both the undergraduate and graduate level were developed. The strengths of both a Hispanic Serving Institution and an NIH-designated Comprehensive Cancer Center were leveraged to develop appropriate research training and professional development activities. The career progression of the participants and degree completion rates was tracked, along with persistent interest in biomedical research in general and cancer and cancer health disparities research in particular for these underrepresented individuals. Finally, this report demonstrates that these training activities increased general knowledge about cancer among participants.
Behavioral model identification (2002)

This paper presents theory and algorithms for system identification suitable for the framework of behavioral system theory. An algorithm based on algebraic system theory and realization theory (Ho-Kalman realization) in a subspace model identification framework is presented. The novel approach considered consists of the formulation of input-output data as an impulse response model and the subsequent application of state-space realization. As a special case, behavioral model identification from finite data sequences is demonstrated.
Diet and inflammation: a link to metabolic and cardiovascular diseases (2005)

Both epidemiological studies and intervention trials support an important role of diet in reducing the risk of a variety of chronic diseases, including cardiovascular disease, and overall mortality. We discuss available evidence indicating that the generation of a pro-inflammatory milieu might be one mechanism through which unhealthy diets are linked to metabolic and cardiovascular diseases. In practical terms, fully understanding the link between diet and inflammation holds the premise to elucidate the mechanisms by which dietary patterns improve cardiovascular health.
Investigating singularities of the observability Jacobian for nonlinear power systems (2005)

This paper focuses on computing and interpreting the significance of the observability Jacobian singularities. Previous efforts have focused on developing an observability index and determining the effects of model/measurement changes to the observability formulation. Using this index, the singularities of the Jacobian are extracted, and preliminary results indicate that there is a duality between the loss of stability (whether it be phase or voltage stability), and the loss of observability. Thus, providing a single dual-use metric capable of forecasting both stability and observability characteristics of a system. The results are illustrated using a sample 3-bus system.
Activation-induced silencing of Thpok defines a new type of CD4 effector T lymphocytes (2011)

CD4 T helper lineage-commitment is initially determined during thymic selection and is driven by the key transcription factor ThPOK. Continuous expression of ThPOK is required to maintain mature MHC class II restricted CD4 T lymphocytes as T helper cells. Here we identify an activation induced differentiation process in vivo that is characterized by the silencing of Thpok and the generation of a new type of antigen-experienced CD4 T cells. This alternative differentiation also prevents activated CD4 T cells from becoming pro-inflammatory effector cells that could damage tissues. Therefore, the data show an unexpected plasticity in mature CD4 T lymphocytes, and define a new subtype of activated CD4 T cells characterized by the loss of the ThPOK-controlled T helper phenotype and the gain of cytotoxic and regulatory competence.
Evidence of fatigue, disordered sleep and peripheral inflammation, but not increased brain TSPO expression, in seasonal allergy: A [11C]PBR28 PET study (2017)

Allergy is associated with non-specific symptoms such as fatigue, sleep problems and impaired cognition. One explanation could be that the allergic inflammatory state includes activation of immune cells in the brain, but this hypothesis has not been tested in humans. The aim of the present study was therefore to investigate seasonal changes in the glial cell marker translocator protein (TSPO), and to relate this to peripheral inflammation, fatigue and sleep, in allergy. We examined 18 patients with severe seasonal allergy, and 13 healthy subjects in and out-of pollen season using positron emission tomography (n = 15/13) and the TSPO radioligand [<sup>11</sup>C]PBR28. In addition, TNF-α, IL-5, IL-6, IL-8 and IFN-γ were measured in peripheral blood, and subjective ratings of fatigue and sleepiness as well as objective and subjective sleep were investigated. No difference in levels of TSPO was seen between patients and healthy subjects, nor in relation to pollen season. However, allergic subjects displayed both increased fatigue, sleepiness and increased percentage of deep sleep, as well as increased levels of IL-5 and TNF-α during pollen season, compared to healthy subjects. Allergic subjects also had shorter total sleep time, regardless of season. In conclusion, allergic subjects are indicated to respond to allergen exposure during pollen season with a clear pattern of behavioral disruption and peripheral inflammatory activation, but not with changes in brain TSPO levels. This underscores a need for development and use of more specific markers to understand brain consequences of peripheral inflammation that will be applicable in human subjects.