gebhart/patrepeval huggingface dataset:
Mengkaji Tindakbalas Nanozarah Silika Dioksida (SiO2) dengan Lisozim Dalam Larutan Penimbal (2021)

Kajian ini dilakukan untuk mengkaji kesan tindak balas nanozarah polimer, silika dioksida (SiO2) dengan protein, (Lisozim) dalam larutan penimbal. Tujuan kajian adalah untuk menentukan kestabilan serta kesan interaksi nanozarah SiO2 dengan lisozim sebagai fungsi kepekatan yang dikaji dengan menggunakan spektroskopi ultralembahyung-cahaya nampak (U.V.-Visible). Kaedah yang digunakan dalam kajian ini iaitu kaedah penambahan (serbuk), kaedah cecair homogen, kaedah perpisahan fasa dan kaedah penyerapan (tindakbalas). Hasil kajian mendapati penjerapan lisozim yang bercas positif (hidrofobik) terhadap permukaan nanozarah SiO2 yang bercas negatif (hidrofilik) adalah sesuai pada pH 7.8. Bagi perbezaan nisbah berat SiO2: Lisozim sama ada berat lisozim atau SiO2 tetap, puncak yang diperolehi adalah sekitar 280nm. Kadar penjerapan lisozim bergantung kepada masa tindak balas dan juga faktor pembauran. Saiz nanozarah SiO2 yang kecil menyebabkan ianya mempunyai luas permukaan yang besar berbanding isipadu dan membolehkan lisozim dijerap pada permukaannya tanpa sebarang halangan. Oleh yang demikian dapat disimpulkan bahawa, wujud kestabilan antara lisozim dan SiO2 yang membolehkan penjerapan berlaku dan terbentuknya gumpalan akibat daripada kesan tindak balas. This study was conducted to study the interaction effect of polymer nanoparticles, silica dioxide (SiO2) with protein, (Lysozyme) in buffer solution. The purpose of the study was to determine the stability and the effect of the interaction of SiO2 nanoparticles with lysozyme as a concentration function studied using ultraviolet-visible (U.V.-visible) spectroscopy. The methods used in this study are the addition method (powder), homogeneous liquid method, phase separation method and absorption method (interaction). The results of the study found that the adsorption of positively charged (hydrophobic) lysozyme to the surface of negatively charged SiO2 nanoparticles (hydrophilic) is suitable at pH 7.8. For the difference weight ratio in SiO2: Lysozyme either lysozyme weight or fixed SiO2, the peak obtained is around 280nm. The rate of absorption of lysozyme depends on the reaction time as well as the diffusion factor. The small size of the SiO2 nanoparticles causes it to have a large surface area compared to the volume and allows lysozymes to be adsorbed on its surface without any obstruction. Therefore, it can be concluded that there is a stability between lysozyme and SiO2 that allows adsorption to occur and the formation of agglomeration as a result of the interaction effect.
COMPLETE RESOLUTION OF LARGE RETINAL FOLD AFTER TRANSECTION OF RETROLENTAL MEMBRANE DURING LENS-SPARING VITRECTOMY FOR RETINOPATHY OF PREMATURITY (2015)

Surgical treatment for retinopathy of prematurity was considerably advanced by the introduction of lens-sparing vitrectomy techniques; however, cases developing retrolental membranes often persisted with poor visual outcomes, and lensectomy is conventionally performed. However, in select cases of Stage 4A retinopathy of prematurity, careful transection of retrolental membranes during lens-sparing vitrectomy using the appropriate technique may provide very good anatomical and visual outcomes.
Identification de facteurs d'intégration quantitatifs et qualitatifs des néologismes à la langue spécialisée médicale: une analyse sur corpus diachronique entre 2007 et 2015 (2020)

La evolución del lenguaje médico refleja los avances médicos y se caracteriza por la creación neológica destinada a nombrar nuevos descubrimientos e innovaciones. Por lo tanto, la creación neológica, la variación terminológica y la desaparición del término demuestran el progreso de la investigación.\n\t\t\t\t Mi estudio se basa en la identificación y el análisis diacrónico de "criterios de supervivencia" que influyen en las probabilidades de que los neologismos incorporen el lenguaje médico. Estos criterios de supervivencia incluyen datos cuantitativos que probablemente brinden información sobre el grado de establecimiento de un determinado neologismo (frecuencia de uso y tasa de distribución) y datos cualitativos que también puedan revelar información sobre el significado de los neologismos, sobre competidores terminológicos potenciales (análisis contextual, existencia potencial de variación terminológica).\n\t\t\t\t Una perspectiva diacrónica debería resaltar las tendencias evolutivas comúnmente compartidas por los neologismos, sus variantes y sus equivalentes extranjeros para predecir cuáles deberían sobrevivir y por qué.
Delta E effect in obliquely field annealed METGLAS R2605SC (1989)

Measurements have been made of the Delta E effect for ribbon specimens of METGLAS 2605SC annealed in fields at angles between 60 degrees and 90 degrees to the long axis. The magnetoelastic behavior of obliquely annealed amorphous ribbons demonstrates features that cannot be explained by the original Livingston model of simple moment rotation. An extension of the Livingston model has been developed and is used to obtain theoretical curves that reproduce the main features of the results. It has been found necessary to include a distribution of initial moment angles, as proposed by M. Melamud et al. (1987), and also a distribution of anisotropy fields.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Sudden Cardiac Death After Myocardial Infarction in Type 2 Diabetic Patients With No Residual Myocardial Ischemia (2012)

Post-MI patients with DM, even in the absence of residual myocardial ischemia clinically, were at higher risk of sudden cardiac death than their non-DM counterparts.
A novel magnetic compass calibration method based on improved ellipse model (2010)

A novel parameter adaptive estimation method based on improved ellipse fitting model is proposed to calibrate the interference error by using GPS heading reference. A process is developed with estimating accurate parameters base on LMS adaptive algorithm. The experimental results show that compensation result of this method is better. It enables the digital magnetic compass realize automatic error compensation.
Frequency-domain properties of Kalman filters (1987)

This paper explores the frequency-domain characteristics of the steady-state Kalman filter. It gives insight into the properties of the filter that are useful for analysis and design. The results are illustrated by a number of industrial applications.
Engineering a Functionalized Biofilm-Based Material for Modulating Escherichia Coli’s Effects in the Mammalian Gastrointestinal Tract (2015)

This study investigates the potential use of engineered bacterial biofilms as programmable platforms to control bacterial-epithelial interactions in the mammalian gut. It is clear that commensal microflora play a critical role in the healthy functioning of the gastrointestinal tract, so this work seeks to use engineered biofilms to enhance and direct the therapeutic effects of such microbes. It is hypothesized that E. coli strains can be engineered to produce biofilm-based materials functionalized with peptides that will enhance colonization and modulate localized adhesion in the gut, while providing direct thera- peutic effects themselves. A library of peptides has been identified, including the trefoil factor family peptides, as strong candidates for biofilm functionalization and E. coli have been successfully engineered to display these peptides on curli fibers that compose the extracellular biofilm. In vitro studies with epithelial cell cultures have demonstrated that E. coli secreting these modified curli fibers have enhanced epithelial adhesion, representing a strong starting point for the development of the desired programmable platform. Such a programmable platform has numerous potential downstream applications, such as producing and immobilizing therapeutic peptides and targeting specific inflammation sites, which could positively affect the treatment of inflammatory bowel diseases, such as ulcerative colitis and Crohn’s disease, which affect more than 1.4 million Americans.
The Mycoplasma genitalium MG_454 Gene Product Resists Killing by Organic Hydroperoxides (2009)

Mycoplasma genitalium is the smallest self-replicating organism and a successful human pathogen associated with a range of genitourinary maladies. As a consequence of its restricted genome size, genes that are highly conserved in other bacteria are absent in M. genitalium. Significantly, genes that encode antioxidants like superoxide dismutase and catalase-peroxidase are lacking. Nevertheless, comparative genomics has revealed that MG_454 of M. genitalium encodes a protein with putative function as an organic hydroperoxide reductase (Ohr). In this study, we found that an M. genitalium transposon mutant that lacks expression of MG_454 was sensitive to killing by t-butyl hydroperoxide and cumene hydroperoxide. To understand whether this sensitivity to hydroperoxides was linked to MG_454, we cloned this gene behind an arabinose-inducible PBAD promoter in plasmid pHERD20T and transformed this construct (pHERDMG454) into a Pseudomonas aeruginosa strain having deletion in its ohr gene (ohr mutant) and showing sensitivity to organic hydroperoxides. The P. aeruginosa ohr mutant harboring pHERDMG454, when induced with arabinose, was able to reverse its sensitivity to organic hydroperoxides, thus supporting the notion that the product of MG_454 resists organic hydroperoxides in M. genitalium. Surprisingly, real-time reverse transcription-PCR showed that expression of MG_454 in M. genitalium was not elevated in response to oxidative stress but was elevated in response to physical stresses, like salt (NaCl) and heat. Although failure of MG_454 to respond to oxidative stress in M. genitalium implies the absence of a known oxidative stress response regulator in the genome of M. genitalium, elevated expression of MG_454 due to physical stress suggests its control by an unidentified regulator.
Full-duplex single fiber transmission using FSK downstream and IM remote upstream Modulations for fiber-to-the-home (2005)

Full-duplex single fiber bidirectional transmission, using frequency-shift-keying modulation for downstream, by direct modulation of a tunable laser, and intensity modulation for upstream, in a wavelength-division-multiplexing passive optical access network is demonstrated. The optical network unit, located at the end user premises, reflects and orthogonally remodulates the received light. Rayleigh scattering effects are reported and analyzed. The system shows proper operation up to 1 Gb/s at 30-km reach.
Stability studies of 14C-Cytostasan solutions and its extraction using dicarbolide of cobalt. (1988)

In this study the stability of 14C-Cytostasan (1, bendamustine), in water solutions was investigated. In distilled water a rapid degradation of carrier-free 14C-1 occurred. The degradation products of 14C-1 are 14C-monohydroxy-1 and 14C-dihydroxy-1 (evidence with the TLC). The degradation rate of 14C-1 was reduced by addition of nonlabelled 1 to the 14C-1 stock solution. The possibility of using distribution coefficient as a stability indicator of 14C-1 solutions was investigated. A number of organic solvents ranging from polar to nonpolar were used for extraction of 14C-1 from water solution. Only ethyl acetate was slightly effective. The distribution coefficient of 14C-1 was dramatically enhanced in presence of dicarbolide of cobalt (DC-H+) in benzene at extraction from HClO4 (0.5 mol.l-1).
Biohybrid Soft Robots Driven by Contractions of Skeletal Muscle Tissue (2022)

In this letter, we introduce biohybrid robots powered by skeletal muscle tissue. Culturing myoblast-laden extracellular matrix structures enables the construction of skeletal muscle tissue in vitro . Biohybrid robots constructed by the integration of such fabricated muscle tissue with robot skeletons have achieved various movements, according to the configuration of the skeleton. We believe that biohybrid robots will increasingly become available in the field of robotics.
Flexible Top-Gated Monolayer MoS2 Transistors with High Mobility (2019)

Flexible electronics could greatly benefit from the realization of large-scale field-effect transistors (FETs) based on two-dimensional (2D) materials that exhibit high carrier mobility, flexibility, and transparency [1]. As high-quality 2D materials are synthesized at high temperatures <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$&gt; 500\ {}^{\circ}\mathrm{C}$</tex> , they must rely on scalable processes for transfer to flexible substrates after growth. However, such transfer processes typically transfer the 2D material using scaffolds of poly(methyl methacrylate) (PMMA) and immersion in corrosive solutions, which can damage the 2D film and leave unwanted residues [2].
Special Section Guest Editorial: Thermal Photonics in Energy (2019)

The <i>Journal of Photonics for Energy</i> (JPE) covers fundamental and applied research areas focused on the applications of photonics for renewable energy harvesting, conversion, storage, distribution, monitoring, consumption, and efficient usage.
Relevant aspects in designing a photovoltaic inverter for industrial and commercial applications (2010)

This paper presents design considerations for grid connected photovoltaic inverters intended for use in industrial and commercial applications. Important aspects such as efficiency, reliability, construction constraints, control, standards and grid codes compliance are discussed. On the other hand, characteristics of a 600 V system based on Japanese standards and a 900 V system based on IEC standards are compared and discussed. Experimental data for a 2 kW down-scaled prototype are presented along with test data for 250 kW isolated and transformerless units built under Japanese standards and IEC standards.
Comprehensive Review of Polymer Architecture for All-Solid-State Lithium Rechargeable Batteries (2020)

Solid-state batteries are an emerging option for next-generation traction batteries because they are safe and have a high energy density. Accordingly, in polymer research, one of the main goals is to achieve solid polymer electrolytes (SPEs) that could be facilely fabricated into any preferred size of thin films with high ionic conductivity as well as favorable mechanical properties. In particular, in the past two decades, many polymer materials of various structures have been applied to improve the performance of SPEs. In this review, the influences of polymer architecture on the physical and electrochemical properties of an SPE in lithium solid polymer batteries are systematically summarized. The discussion mainly focuses on four principal categories: linear, comb-like, hyper-branched, and crosslinked polymers, which have been widely reported in recent investigations as capable of optimizing the balance between mechanical resistance, ionic conductivity, and electrochemical stability. This paper presents new insights into the design and exploration of novel high-performance SPEs for lithium solid polymer batteries.
Genotoxic Effects of Tobacco on Buccal Epithelium: Cell Nuclear Anomalies as Biomarker (2014)

Background: Tobacco use has toxic effects on different organs. This study was carried out to assess the effect of indigenous tobacco both in smoking (bidi) and smokeless (gutkha, zarda and khaini) forms on buccal cells at chromosomal level, through assessment of different nuclear anomalies as biomarker. Methods:This study was done on people living in Durgapur and its adjacent areas, West Bengal, India during January to July 2011. The samples were collected from 50 smokers (case group), 50 smokeless tobacco consumers or chewers (case group) and 50 non-tobacco consumers (control group). Micronucleus assay was used to assess buccal cell nuclear changes. Buccal smears collected from study subjects were prepared on a grease free slide. Prepared slides were observed under light microscope and 2 to 5 fields were observed randomly for counting the different anomalies. In each field, the frequency of each anomaly was assessed in 100 cells and reported with percentage. Results:Chewers had significantly the highest frequency of all nuclear anomalies compared to smokers and healthy controls (HCs). Smokers also had significantly more anomalies compared to HCs. Condensed chromatin (CC), karyolysis (KL) and bi-nucleation (BN) in chewers and CC, pyknosis and BN in smokers were the most frequent anomalies. KL was significantly more frequent in chewers compared to smokers (59.8 ± 6.4 vs. 24.2 ± 12.4%, P < 0.001), however, the frequency of other nuclear anomalies were not significantly different in these two study groups. Presence of each nuclear anomaly was significantly greater in older ages in all study groups. Conclusion:Tobacco can cause and increase the rate of nuclear anomalies in both smoking and smokeless forms compared to HCs. The genotoxic effects of tobacco on buccal cells are partly age-related. Cell nuclear anomalies in buccal tissue can be used as biomarker indicating the detrimental effects of tobacco.
ChemInform Abstract: AKTIVITAETSKOEFFIZIENT UND VERWANDTE THERMODYNAMISCHE GROESSEN VON HCL IN 5 GEWICHTS‐PZ. BUTANOL‐(1) (1972)

Abstract EMK‐Messungen wurden bei 5 verschiedenen Temperaturen im Bereich von 5‐45°C an folgender Zelle durchgeführt: Pt; H2(g, l Atm)/HCl (M) in 5 Gew.% 1‐Butanol, AgCl/Ag.
Association of pronounced Elevation of NET formation and Nucleosome Biomarkers with Mortality in Patients with Septic Shock (2023)

Abstract Background: Understanding the mechanisms underlying immune dysregulation in sepsis is a major challenge in developing more individualized therapy, as early and persistent inflammation, as well as immunosuppression, play a significant role in pathophysiology. As part of the antimicrobial response, neutrophils can release extracellular traps (NETs) which neutralize and kill microorganisms. However, excessive NETs formation may also contribute to pathogenesis, tissue damage and organ dysfunction. Recently, a novel automated assay has been proposed for the routine measurement of nucleosomes H3.1 (fundamental units of chromatin) that are released during NETs formation. The aim of the present study was to measure nucleosome levels in septic shock patients and to determine association with mortality. Methods: 151 septic shock patients (SEPSIS-3 definition, IMMUNOSEPSIS cohort) were included. Plasma samples were obtained at 3 time-points (day 1-2, 3-4, 6-8 after admission). Nucleosomes H3.1 were measured using a chemiluminescent immunoassay. IL-6 and immunological cellular parameters were concomitantly assessed. Results: The nucleosome H3.1 levels were markedly and significantly elevated at all-time points compared to the control group. Immunological parameters indicated tremendous early inflammation (IL-6 = 1335 pg/mL at day 1-2) along with marked immunosuppression (e.g., mHLA-DR = 3853 AB/C and CD4 = 338 /µL at day 3-4). We found significantly positive correlation between nucleosome levels and organ failure and severity scores, IL-6 concentrations and neutrophil count. Significantly higher values (day 1-2 &amp; 3-4) were measured in non-survivor patients (28-day mortality). This association was still significant after multivariate analysis and was more pronounced with highest concentration. Early (day 1-2) increased nucleosome levels were also independently associated with 5-day mortality. At day 6-8, persistent elevated nucleosome levels were negatively correlated to mHLA-DR values. Conclusions: This study reports a significant elevation of nucleosome in patients during a one-week follow-up. The nucleosome levels showed correlation with neutrophil count, IL-6 and were found to be independently associated with mortality assessed at day 5 or 28. Therefore, nucleosome concentration seems to be a promising biomarker for detecting hyper-inflammatory phenotype upon a patient's admission. Additional investigations are required to evaluate the potential association between sustained elevation of nucleosome and sepsis-induced immunosuppression.
3-D analysis of cellular lipid metabolism: Reconstruction of the tubular network (1992)

A predominant feature of early atherosclerotic lesions is the presence of macrophages and smooth muscle cells in which large quantities of lipid have accumulated. This lipid occurs within both small, cytoplasmic, cholesterol ester droplets and large, lipid-swollen secondary lysosomes. Time resolved studies suggest lysosomal engorgement promotes the disease progression. Using cultured cells we have shown that lysosomal engorgement in smooth muscle cells is accompanied by the elaboration of an extensive network of tubules. The tubules are rich in acid hydrolases and appear to be an extension of the trans Golgi network. As part of our effort to understand the causes and significance of lysosomal lipid accumulation we have undertaken to characterize the extent and development of the tubular network. The tortuous nature of the network makes it difficult to visualize by conventional thin section electron microscopy. Thus, intermediate voltage electron microscopy of thick (1-3 um) sections in which the tubules have been contrasted using acid phosphatase cytochemistry has been essential to these studies. Cultured rabbit smooth muscle cells were incubated with sonicated lipid droplets composed of 72% cholesteryl oleate, 25% triolein, and 3% phospholipid. Prior to incubation, cells had no visible lipid stores and 92% of cells showed no acid phosphatase-containing tubules. In cells with tubules, the tubules occupied less than 0.1% of the cell volume. In contrast, after 4 h of exposure to droplets 81% of cells showed lysosomal lipid accumulation with 67% exhibiting extensive, interconnecting, acid phosphatase positive tubular networks. Although stereo-pair images provided much information about the extent of the network (figure 1), the exact relationship of the network to lipid-engorged lysosomes was somewhat ambiguous due to superposition of objects. In order to clarify the relationship of network to lysosome, a tomographic reconstruction was computed from an IVEM tilt series encompassing +/− 60° in 2° increments. Images were digitized using a DAGE model 81 video camera. Rotational alignment using fiduciary markers was accomplished using the algorithm described by Lawrence. Translational alignment and weighted back-projection reconstruction were carried out as described by McEwen. Volumes were rendered using a PIXAR computer graphics workstation. The reconstruction (figure 2) revealed that extensions of the network made contact with the lipid-swollen lysosomes suggesting that the network might transfer hydrolases directly to secondary lysosomes.
Gli2 Mediated Activation of Hedgehog Signaling Attenuates Acute Pancreatitis via Balancing Inflammatory Cytokines in Mice (2018)

This study indicates that Hh activation during AP development is a negative feedback of the inflammatory response, restricting inflammatory injury to the pancreas and other tissues. Thus, manipulation of Hh signaling should shed light on limiting inflammation and alleviating AP damage.
Stochastic optimization algorithm with probability vector in mathematical function minimization and travelling salesman problem (2010)

In the paper there is introduced the newly developed optimization method the Stochastic Optimization Algorithm with Probability Vector (PSV). It is related to Stochastic Learning Algorithm with Probability Vector for artificial neural networks. Both algorithms are inspired by stochastic iterated function system SIFS for generating the statistically self similar fractals. The PSV is gradient method where the direction of individual future movement from the population is based stochastically. PSV was tested on mathematical function minimization and on the travelling sales man problem. The influence of the quantity of individuals upon the best achieved fitness function was also tested on the mathematical functions minimization.