gebhart/patrepeval huggingface dataset:
Entanglement Networks of 1,2-Polybutadiene Cross-Linked in States of Strain. 3. Effect of Temperature (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEntanglement Networks of 1,2-Polybutadiene Cross-Linked in States of Strain. 3. Effect of TemperatureRick L. Carpenter, Ole Kramer, and John D. FerryCite this: Macromolecules 1977, 10, 1, 117–119Publication Date (Print):January 1, 1977Publication History Published online1 May 2002Published inissue 1 January 1977https://pubs.acs.org/doi/10.1021/ma60055a024https://doi.org/10.1021/ma60055a024research-articleACS PublicationsRequest reuse permissionsArticle Views121Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ELDER ABUSE IN PEOPLE WITH DEMENTIA IN NORTHERN IRELAND: PREVALENCE AND PREDICTORS IN CASES REFERRED TO A PSYCHIATRY OF OLD AGE SERVICE (1997)

Elder abuse is associated with aspects of the patient/carer relationship and should be regarded as a significant problem in patients with dementia referred to an old age service.
Application-layer mobility support for streaming real-time media (2004)

This paper presents an UDP-based socket extension called the resilient mobile socket (RMS), which provides application-layer mobility support by encapsulating other sockets into a new aggregated socket abstraction. Encapsulated sockets can then be added or removed without disturbing running applications. RMS also provides a method for soft handovers where several encapsulated sockets are used simultaneously during a handover. As a proof of concept, a working prototype has been built by integrating RMS with Marratech Pro, a commercially available e-meeting application. This prototype has been used to evaluate RMS and to investigate how GSM audio quality is affected by handovers. The result from the investigation shows that soft handovers can be executed without loosing packets or causing extra latency, while a hard handover in average took around 200 ms to complete. This indicates that proactive handovers and redundancy are important, but that more work must he done to predict disconnections.
Determining the Thermodynamic and Kinetic Association of a DNA Aptamer and Tetracycline Using Isothermal Titration Calorimetry (2022)

The determination of binding affinity and behavior between an aptamer and its target is the most crucial step in selecting and using an aptamer for application. Due to the drastic differences between the aptamer and small molecules, scientists need to put much effort into characterizing their binding properties. Isothermal Titration Calorimetry (ITC) is a powerful approach for this purpose. ITC goes beyond determining disassociation constants (Kd) and can provide the enthalpy changes and binding stoichiometry of the interaction between two molecules in the solution phase. This approach conducts continuous titration using label-free molecules and records released heat over time upon the binding events produced by each titration, so the process can sensitively measure the binding between macromolecules and their small targets. Herein, the article introduces a step-by-step procedure of the ITC measurement of a selected aptamer with a small target, tetracycline. This example proves the versatility of the technique and its potential for other applications.
Synthesis of cis-1,2-cyclobutanediols via intramolecular pinacol coupling of 4-oxo aldehydes (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of cis-1,2-cyclobutanediols via intramolecular pinacol coupling of 4-oxo aldehydesAndre S. Raw and Steven F. PedersenCite this: J. Org. Chem. 1991, 56, 2, 830–833Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/jo00002a059https://doi.org/10.1021/jo00002a059research-articleACS PublicationsRequest reuse permissionsArticle Views1069Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Solar cell arcing: The role of outgassing and contamination (1992)

The effect of outgassing, venting, and thruster firing events on spacecraft system performance has been a long standing issue. Recent laboratory measurements on negatively biased high voltage solar cells at Physical Sciences Inc. (PSI) suggest that some currently designed and certainly future space power systems must address/re-evaluate this issue. Our observations show that exposing these cells to moderate levels (10 exp -3 torr-min) of H2O vapor enhances the arcing frequency, while heating to 85 C to remove water vapor significantly reduces the arc frequency. The interaction of the adhesive used to attach the cover glass to the solar cell with ambient water vapor is the key factor in determining arcing rates. Elimination of adhesive exposed to the environmental plasma reduces the arc frequency more than two orders of magnitude, and eliminates any sensitivity to H2O exposure. The adhesive may also become a source of spacecraft contamination. Macroscopic amounts were observed to blow off some arc events, and (we assume) electrostatically precipitate at other negatively biased locations. Data, analysis, and potential impact for future space platforms are discussed.
Optimal synchronization of oscillatory chemical reactions with complex pulse, square, and smooth waveforms signals maximizes Tsallis entropy (2015)

We show that the mathematical structure of Tsallis entropy underlies an important and ubiquitous problem in nonlinear science related to an efficient synchronization of weakly forced nonlinear oscillators. The maximization of the locking range of oscillators with the use of phase models is analyzed with general constraints that encompass forcing waveform power, magnitude, or area. The optimization problem is then recasted as a general form of Tsallis entropy maximization. The solution of these optimization problems is shown to be a direct consequence from Hölder's inequality. The resulting new maximization principle is confirmed in numerical simulations and experiments with chemical oscillations with nickel electrodissolution. While weakly nonlinear oscillators have generic optimal waveforms (sinusoidal, 50% duty cycle square wave, and equally paced bipolar pulses for power-, area-, and magnitude-constraints, respectively), strongly nonlinear oscillators require more complex waveforms such as smooth, square, and pulse ones.
Landscape Review of Mail-in Self-Collection, Programs for Sexually Transmitted Infections (2023)

Mail-in self-collection services are ubiquitous and exist in all states except 2; STI testing public health programs that offer testing at no cost to the consumer are only in 46% of states. Mail-in testing is likely a permanent fixture in sexual health services and will be an important component of a hybrid approach that complements that of static clinic services.
Increased production of tumor necrosis factor-alpha and release of soluble CD4 and CD8 molecules, but decreased responsiveness to phytohemagglutinin in patients with nasopharyngeal carcinoma. (1994)

Twelve patients with nasopharyngeal carcinoma (NPC) were studied for spontaneous and phytohemagglutin (PHA)-stimulated production of cytokines, soluble markers and [3H] thymidine incorporation by mononuclear cells. The same number of patients with skin cancer and healthy subjects were used as control groups. Our results showed that the NPC group produced much more tumor necrosis factor-alpha (TNF alpha), soluble CD4 (sCD4) and CD8 (sCD8) in PHA-stimulated mononuclear cell supernatants than those in the other two groups. The levels of soluble interleukin-2 receptor (sIL-2R) and gamma-interferon (IFN gamma) in PHA-stimulated supernatants were at the same high level in the NPC and healthy subjects groups while the concentrations were much lower in the skin cancer group. We also noticed that the early stage group in NPC patients had higher levels of interleukin-1 alpha (IL-1 alpha), TNF alpha, IFN gamma and sIL-2R in both spontaneous and PHA-stimulated mononuclear cell supernatants. The stimulation index of PHA-responsiveness was 155, 5.2 and 37, respectively, in the healthy subjects, skin cancer and NPC groups. The PHA-responsiveness was depressed in both the NPC and skin cancer groups. It seems that cancer patients have an impaired T cell mitogenic response after mitogen stimulation. NPC patients had better immune response than skin cancer patients in immune factor release or PHA-responsiveness.
Daratumumab eradicates minimal residual disease in a preclinical model of pediatric T-cell acute lymphoblastic leukemia (2019)

TO THE EDITOR:

Novel immunotherapies have recently led to a broadened spectrum of therapeutic options in pediatric B-cell precursor acute lymphoblastic leukemia, even in the setting of relapsed/refractory disease. However, antibody therapy for T-cell acute lymphoblastic leukemia (T-ALL) is
j5 DNA Assembly Design Automation (2013)

Modern standardized methodologies, described in detail in the previous chapters of this book, have enabled the software-automated design of optimized DNA construction protocols. This chapter describes how to design (combinatorial) scar-less DNA assembly protocols using the web-based software j5. j5 assists biomedical and biotechnological researchers construct DNA by automating the design of optimized protocols for flanking homology sequence as well as type IIS endonuclease-mediated DNA assembly methodologies. Unlike any other software tool available today, j5 designs scar-less combinatorial DNA assembly protocols, performs a cost-benefit analysis to identify which portions of an assembly process would be less expensive to outsource to a DNA synthesis service provider, and designs hierarchical DNA assembly strategies to mitigate anticipated poor assembly junction sequence performance. Software integrated with j5 add significant value to the j5 design process through graphical user-interface enhancement and downstream liquid-handling robotic laboratory automation.
D6.1: Robust Prognostics Methods And Algorithms (2015)

This deliverable depicts the prognostics approach developed on the SAPPHIRE project. This approach is based on a behavioral physics-based model.
Continuous Network Interdiction (2006)

Abstract : This report deals with network interdiction campaigns that are expected to be carried out indefinitely in time. Two sides are always involved, one desiring the unimpeded movement of some commodity, while the other desires the opposite. We consider two distinct situations. The first is motivated by warfare involving Improvised Explosive Devices (TEDs) directed against the movement of materiel in convoys on roads. It will be assumed that this kind of warfare is low level in the sense of destroying only a negligible fraction of the shipped materiel, so the objective becomes the maximization or minimization of the rate at which the convoys take lethal hits. The second situation is an economic one where the interdictor attempts to capture a significant fraction of the shipped materiel, so much so that a profit cannot be made by shipping it. This leads to a Nash equilibrium where the shipper's quantity shipped is in equilibrium with the interdictor's budget for interdiction.
Effect of catheter positioning on the variability of measured gradient in aortic stenosis (1993)

The purpose of this study was to quantify the variation in measured aortic valve gradient and calculated aortic valve area when different techniques of cardiac catheterization were utilized. Hemodynamic assessment of aortic stenosis severity requires an accurately determined pressure gradient. In aortic stenosis, the presence of intraventricular pressure gradients and downstream pressure recovery within the aorta means that a range of aortic valve gradients could be measured in a given patient depending upon catheter position and measurement technique. To quantify the degree of variation in measured gradient and calculated aortic valve area, we generated transvalvular gradients by nine different techniques in 15 patients (11 men, 4 women; 29-86 years old). Patients were divided into those with severe aortic stenosis (aortic valve area < or = 0.6 cm2, n = 6) and those with moderately severe aortic stenosis (aortic valve area 0.61-0.90 cm2, n = 9). Considerable variation in measured gradient and calculated aortic valve area was observed. The maximum variation in gradient was similar in severe and moderately severe aortic stenosis groups (33 mm Hg. vs. 32 mm Hg., p = NS). However, the variation in gradient as a percent of maximum gradient was greater (P < 0.05) in the moderately severe aortic stenosis group. The maximum variation in calculated aortic valve area was 0.1 cm2 in the severe group and 0.3 cm2 in the moderately severe group (P < 0.01). An intraventricular gradient, present in 13 of 15 (87%) patients, was partially responsible for the variation in pressure gradient measurement and calculated aortic valve area.(ABSTRACT TRUNCATED AT 250 WORDS)
P3‐229: Trans‐synaptic degeneration following acute axonal severing and beta‐amyloid deposits in reconstructed neuronal networks (2011)

The brain is a complex structure comprising many different neuronal populations making specific and polarized connections. The establishment of synaptic contacts are key events in brain development, and conversely, synaptic degeneration is an early and seminal process in various acute syndromes and neurodegenerative diseases eg, Alzheimer's disease (AD). The molecular mechanisms involved in both synaptic and axonal degeneration remain to be elucidated. Importantly, since neurons are highly polarized cells, both chronic and acute brain injuries induce localized insults that targets subparts of neurons and/or neuronal networks. However, the “distal” consequences of such focal aggression on the neuronal integrity are still unknown. Moreover, recent studies reveal that neurodegenerative hallmarks in AD (beta amyloid accumulation and tau phosphorylation) progress both spatially and temporally following specific neuronal pathways. This calls for studies analyzing acute and chronic neurodegenerative processes in neuronal networks. In this study, we use a new micro-fluidic culture platform that enables the in vitro reconstruction of oriented neuronal networks with two or three different interconnected neuronal populations (cortex, striatum and hippocampus) each one being individually accessible. We used these reconstructed networks to model i) acute cortical axon severing or ii) the effect offocalized Aß deposition on a restricted area of the network to evaluate their consequences on distant axonal and synaptic integrity. Our results show that both, cortical axon severing and cortical amyloid deposition leads to the propagation of an anterograde degenerative signal involving distant axo-dendriticsynaptic disconnection. Interestingly, this synaptic collapse is associated with an altered glutamatergic neurotransmission that culminates in trans-synaptic degenerative events in the connected post-synaptic neurons. Comparing the vulnerability of different post synaptic neurons, we test whether insults restricted to presynaptic cortical neurons leads to the propagation of degeneration along preferentialneur onal pathways. In conclusion our work aims at assessing the cellular and molecular mechanisms involved in the progression of degenerative events along neuro-anatomical pathways.
p53 responsive nucleotide excision repair gene products p48 and XPC, but not p53, localize to sites of UV-irradiation-induced DNA damage, in vivo (2003)

The p53 tumor suppressor gene is an important mediator of the cellular response to ultraviolet (UV)-irradiation-induced DNA damage and affects the efficiency of the nucleotide excision repair (NER) pathway. The mechanism by which p53 regulates NER may be through its ability to act as a transcription factor, and/or through direct interactions with damaged DNA or the repair machinery. p53 has been shown to regulate the expression of the DDB2 gene (encoding the p48 protein) and the XPC gene, two important components of the NER pathway involved in DNA damage recognition. In this study, a localized UV-irradiation technique was used to examine the localization of p53, p48 and XPC proteins in relation to sites of UV photoproducts, in vivo. We did not observe any specific co-localization of p53 with sites of UV-induced DNA damage, but did observe rapid co-localization of both p48 and XPC to these sites. p48 bound to UV photoproducts in cells mutant or deficient for either p53, XPC or XPA, and p48 enhanced XPC binding to lesions, suggesting that p48 is a very early recognition factor of DNA damage. We propose that p53 functions to transcriptionally regulate the DDB2 and XPC NER genes, but does not activate the NER pathway through direct interactions with UV-induced damaged DNA or other repair factors.
Stimulation of enzyme activities by fragments of calmodulin (1981)

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Pt/GaN Schottky diode for propene (C3H6) gas sensing (2008)

Quasinormal-mode treatment is extended to the description of scalar field behavior in one-dimensional photonic crystals. A one-dimensional photonic crystal is a particular configuration of an open cavity, where discontinuities of the refractive index give rise to field confinement. This paper presents, for a one-dimensional photonic crystal, a discussion about the completeness of the quasinormal-mode representation and, moreover, a discussion on the complex eigenfrequencies, as well as the corresponding field distribution. The concept of density of modes is also discussed in terms of quasinormal modes.
Faisabilité d'un critère de performance pour les jambières de protection portées par les opérateurs de scie à chaîne (1985)

Le but de ce travail est d'établir la faisabilité d'un critère de performance et d'un banc d'essai correspondant pour évaluer le niveau de protection des jambières portées par les opérateurs de scies à chaines. Une revue bibliographique ainsi que des contacts avec trois des quatre organismes qui effectuent des essais sur les jambières nous ont permis de comparer les méthodes et les résultats de chacun et de faire nos recommandations. Il y a principalement deux critères de performance pour évaluer le niveau de protection: le temps de traversée et la vitesse limite de la chaine. De plus, les bancs d'essai utilisent un moteur électrique ou à combustion lors des essais. Suite à cette étude nous recommandons un moteur à combustion pour mener à bien les essais et l'utilisation du temps de traversée comme critère de performance.
Classification of electromyographic signals during finger isometric flexion: Using electrodes arrays (2011)

The classification of electromiographic signals provides a method to identify one's intent or movement. This paper presents a study on choosing the best model for a classifier used to group electromiographic signals into classes corresponding to the isometric flexion effort of different fingers. The signals were collected from the Flexor Digitorum Superficialis and Profundus of seven healthy subjects. Different features (root mean square - RMS, average rectified value - ARV, mean and median frequency) and different classifier structures (discriminant analysis, nearest neighbor analysis, naive Bayes algorithm, neural network, fuzzy logic based algorithm) were implemented with classification success rates ranging from 50 to 99 %. The success rate of the classifiers corresponds to the ability of a numerical system to decode the physiological manifestations associated with the finger movements
Automatic Lens Design Methods* (1957)

Optical design may be thought of as an exercise in the solution of sets of simultaneous, nonlinear, algebraic equations with prescribed boundary conditions. Several methods for solving such sets of equations are discussed, and numerical examples are given for some of them. These methods are believed suitable for use with automatic computing machinery.In the optical problem there are usually many more equations than variables, so that an exact solution is seldom possible. If, however, the quality of a system is specified by a merit function φ, then a set of parameters which make φ a minimum can be interpreted as a solution of the equations.
Metal-induced layer exchange of group IV materials (2020)

Abstract Layer exchange (LE) is an interesting phenomenon in which metal and semiconductor layers exchange during heat treatment. A great deal of effort has been put into research on the mechanism and applications of LE, which has allowed various group IV materials (Si, SiGe, Ge, GeSn and C) to form on arbitrary substrates using appropriate metal catalysts. Depending on the LE material combination and growth conditions, the resulting semiconductor layer exhibits various features: low-temperature crystallization (80 °C–500 °C), grain size control (nm to mm orders), crystal orientation control to (100) or (111) and high impurity doping (&gt;10 20 cm −3 ). These features are useful for improving the performance, productivity and versatility of various devices, such as solar cells, transistors, thermoelectric generators and rechargeable batteries. We briefly review the findings and achievements from over 20 years of LE studies, including recent progress on device applications.
Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis (2006)

Toll receptors in Drosophila melanogaster function in morphogenesis and host defense. Mammalian orthologues of Toll, the Toll-like receptors (TLRs), have been studied extensively for their essential functions in controlling innate and adaptive immune responses. We report that TLR8 is dynamically expressed during mouse brain development and localizes to neurons and axons. Agonist stimulation of TLR8 in cultured cortical neurons causes inhibition of neurite outgrowth and induces apoptosis in a dissociable manner. Our evidence indicates that such TLR8-mediated neuronal responses do not involve the canonical TLR-NF-kappaB signaling pathway. These findings reveal novel functions for TLR8 in the mammalian nervous system that are distinct from the classical role of TLRs in immunity.