gebhart/patrepeval huggingface dataset:
Disinfective Effect of Hot Water and Ozonized Solution in Antiseptic-resistant Strains of Methicillin-resistant Staphylococcus aureus. (1994)

The effects of hot water and ozonized solution used for disinfection were evaluated in antiseptic-resistant strains of methicillin-resistant Staphylococcus aureus (MRSA). The viable counts of the antiseptic-sensitive and -low level-resistant strains were decreased to ≤102 cfu/ml by exposure to 60°C water within 2 minutes. However, the viable counts of the high levelresistant strain were not decreased to ≤102 cfu/ml by more than 5 minutes exposure to 65°C water.The viable counts of the antiseptic-sensitive, -low level-resistant, and -high level-resistant strains were decreased to ≤102 cfu/ml by exposure to 70°C water within 30 seconds, 30 seconds, and 2 minutes, respectively. Sensitivity to hot water of antiseptic-sensitive derivatives, eliminated the antiseptic-resistant gene ebr, was higher than that of the original antiseptic-resistant strain. Sensitivity to ozonized solution of antiseptic-resistant strain was also lower than that of the antiseptic-sensitive strain. The viable counts of the antiseptic-high level-resistant strain were decreased to ≤102 cfu/ml by exposure to 1.5 ppm ozonized solution within 30 seconds.These results clearly confirm that the antiseptic-resistant gene ebr was relative to a decline in the sensitivity to hot water and ozonized solution in antiseptic-resistant strains, and that 70°C water and 1.5 ppm ozonized solution are a useful means of disinfecting instruments and devices contaminated with antiseptic-resistant strains of MRSA.
Comment on "Application of Biot's Variational Method to Convective Heating of a Slab" (1965)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
See Better Before Looking Closer: Weakly Supervised Data Augmentation Network for Fine-Grained Visual Classification (2019)

Data augmentation is usually adopted to increase the amount of training data, prevent overfitting and improve the performance of deep models. However, in practice, random data augmentation, such as random image cropping, is low-efficiency and might introduce many uncontrolled background noises. In this paper, we propose Weakly Supervised Data Augmentation Network (WS-DAN) to explore the potential of data augmentation. Specifically, for each training image, we first generate attention maps to represent the object's discriminative parts by weakly supervised learning. Next, we augment the image guided by these attention maps, including attention cropping and attention dropping. The proposed WS-DAN improves the classification accuracy in two folds. In the first stage, images can be seen better since more discriminative parts' features will be extracted. In the second stage, attention regions provide accurate location of object, which ensures our model to look at the object closer and further improve the performance. Comprehensive experiments in common fine-grained visual classification datasets show that our WS-DAN surpasses the state-of-the-art methods, which demonstrates its effectiveness.
Activation of Monocytes via the CD14 Receptor Leads to the Enhanced Lentiviral Transduction of Immature Dendritic Cells (2004)

In this study, we compared dendritic cells (DCs) differentiated from positively selected monocytes (CD14-DCs) to DCs differentiated from adherence-selected monocytes (adh-DCs) with emphasis on lentiviral transduction. Using a second-generation, triple-helix containing, self-inactivating lentiviral vector at a multiplicity of infection (MOI) of 15, we observed enhanced transduction of CD14-DCs (72.8 +/- 5.3%, mean fluorescence intensity [MFI] = 166 +/- 76) compared to adh-DCs (32.3 +/- 13.1%, MFI = 119 +/- 76, n = 5). More importantly, the efficiency to transduce adh-DCs was significantly increased when monocytes were incubated with antiCD14 antibody coupled beads, anti-CD14 antibodies, or lipopolysaccharide (LPS), reaching transduction efficiencies up to 86.6%, 53.3%, and 80.9%, respectively. We showed that this enhanced transduction was correlated to an activation of the monocytes, characterized by the up regulation of the cytokines interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha and the de novo synthesis of IL-6 and IL-10. However, the enhanced transduction of immature CD14-DCs was not correlated with a progression in the cell cycle from G(0) to G(1). We further showed that CD14-DCs were phenotypically comparable to adh-DCs. Functional analysis revealed that there were no differences in allostimulatory capacity, production of IL-12 p70 on CD40 ligation or expression of IL-1beta, IL-6, IL-8, IL-10, IL-12, and TNF-alpha as evaluated by reverse transcriptase-polymerase chain reaction (RT-PCR). Finally, we showed that lentivirally transduced CD14-DCs were equally capable as adh-DCs in stimulating MAGE-A3 antigen-specific CD4(+) and CD8(+) T cells in vitro.
Microscopic three-dimensional imaging by digital interference holography (2003)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
Thrombelastography-Guided Factor VIIa Therapy in a Surgical Patient with Severe Hemophilia and Factor VIII Inhibitor (2008)

A patient with hemophilia and factor VIII inhibitors required urgent evacuation of a spinal cord hematoma. Two large doses of recombinant factor VIIa (200 microg/kg followed by 300 microg/kg) were required for hemostasis. Traditional and rotational thrombelastography were used to guide dose and timing of rFVIIa therapy. With the limitations of prothrombin and partial thromboplastin times as perioperative monitors of rFVIIa efficacy, this description of thrombelastography supports reports of in vitro use, and may be helpful when large perioperative doses of rFVIIa are required.
Resuscitation with Lactated Ringer's Solution in Rats with Hemorrhagic Shock Induces Immediate Apoptosis (1999)

Resuscitation with LR solution after hemorrhagic shock increased immediate cell death by apoptosis in both the small intestine and liver. There was no significant increase in apoptosis in the animals resuscitated with hypertonic saline, whole blood, or in unresuscitated animals. Thus, the type of resuscitation fluid used may affect the apoptotic cellular response to shock.
Glycoside Hydrolases as Therapeutic Targets for CNS Indications (2021)

Medicinal Chemistry Reviews is an outstanding 965 page volume providing timely and critical reviews of important topics in medicinal chemistry. It is provided free of charge to MEDI members in electronic format. Members can also order a print copy, for the cost of printing, shipping and handling
El Geocamp: un portal informàtic interuniversitari i una eina d'autoedició per les activitats de camp en geologia (2011)

GEOCAMP(http://einstein.uab.es/_c_gr_geocamp/geocamp) es una proposta d'innovacio educativa desenvolupada per un equip de professors universitaris vinculats a tres universitats catalanes (UdG, UAB i UPC).

GEOCAMP es un portal d'Internet que engloba material docent desenvolupat especificament per optimitzar el proces d'aprenentatge en les activitats de camp de Geologia.

El GEOCAMP ha estat emprat abastament per estudiants de les universitats en les quals l'equip d'autors imparteix docencia. La seva potencialitat i lliure disposicio ha permes que el seu us es generalitzi a d'altres centres i nivells educatius tant a la resta de l'estat com a l'estranger
Nutritional and functional properties and the application of caseinates in the food processing industry (2013)

Kazeiniany to preparaty białkowe otrzymywane przez zobojętnianie kazeiny kwasowej środkami alkalicznymi. Pod względem odżywczym stanowią bogate źródło białka o znacznej wartości biologicznej oraz niektórych składników mineralnych. Do najważniejszych właściwości funkcjonalnych kazeinianów zalicza się rozpuszczalność, wodochłonność, lepkość, żelowanie, wiązanie tłuszczu, emulgowanie i pienienie. Największe znaczenie w przetwórstwie spożywczym ma kazeinian sodu i wapnia. Preparaty te znalazły zastosowanie w przetwórstwie mięsa, produkcji garmażeryjnej, produkcji przetworów zbożowych, piekarnictwie, cukiernictwie, mleczarstwie, produkcji napojów, koncentratów spożywczych oraz otrzymywaniu produktów o specjalnym przeznaczeniu żywieniowym
Perceptions of safety culture vary across the intensive care units of a single institution* (2006)

Significant safety culture variation exists across ICUs of a single hospital. ICU nursing directors tend to overestimate their personnel's attitudes, particularly for teamwork. Culture assessments based on institutional level analysis or director opinion may be flawed.
Bifunctional [2‘,6‘-Dimethyl-l-tyrosine]endomorphin-2 Analogues Substituted at Position 3 with Alkylated Phenylalanine Derivatives Yield Potent Mixed μ-Agonist/δ-Antagonist and Dual μ-Agonist/δ-Agonist Opioid Ligands (2007)

Endomorphin-2 (H-Tyr-Pro-Phe-Phe-NH2) and [Dmt1]EM-2 (Dmt = 2',6'-dimethyl-l-tyrosine) analogues, containing alkylated Phe3 derivatives, 2'-monomethyl (2, 2'), 3',5'- and 2',6'-dimethyl (3, 3', and 4', respectively), 2',4',6'-trimethyl (6, 6'), 2'-ethyl-6'-methyl (7, 7'), and 2'-isopropyl-6'-methyl (8, 8') groups or Dmt (5, 5'), had the following characteristics: (i) [Xaa3]EM-2 analogues exhibited improved mu- and delta-opioid receptor affinities. The latter, however, were inconsequential (Kidelta = 491-3451 nM). (ii) [Dmt1,Xaa3]EM-2 analogues enhanced mu- and delta-opioid receptor affinities (Kimu = 0.069-0.32 nM; Kidelta = 1.83-99.8 nM) without kappa-opioid receptor interaction. (iii) There were elevated mu-bioactivity (IC50 = 0.12-14.4 nM) and abolished delta-agonism (IC50 > 10 muM in 2', 3', 4', 5', 6'), although 4' and 6' demonstrated a potent mixed mu-agonism/delta-antagonism (for 4', IC50mu = 0.12 and pA2 = 8.15; for 6', IC50mu = 0.21 nM and pA2 = 9.05) and 7' was a dual mu-agonist/delta-agonist (IC50mu = 0.17 nM; IC50delta = 0.51 nM).
Implantation of a vagus nerve stimulator for patients with heart failure with reduced ejection fraction: An educational video (2022)

Current, ongoing studies, such as the ANTHEM-HFrEF Pivotal Study, are designed to determine the long-term effects of VNS on heart failure symptoms, hospitalization rates, and survival. The VNS-implantation procedure was straightforward.
Insect production and utilization of insect products in the USA and Canada. (2021)

This chapter discussed the history of the sale and production of live insects as ingredients in pet food and animal feed in North America, Canada, and USA. Highlights focused on the purpose of using insects as feed and on the currents species available in the market such as crickets Acheta domesticus, Gryllodes sigillatus, yellow mealworms (Tenebrio molitor), superworms (Zophobas morio), waxworms (Galleria mellonella), black soldier fly larvae (BSFL) (Hermetia illucens), silkworms (Bombyx mori) and fruit flies (Drosophila melanogaster and Drosophila hydei).
NEW CONCATENATION SCHEMES BASED ON THE MULTITHRESHOLD DECODERS OF CONVOLUTIONAL SELF-ORTHOGONAL CODES FOR GAUSSIAN CHANNELS (2021)

New serial concatenation schemes based on the multithreshold decoders and di- vergent principle for the convolutional self-orthogonal codes under Gaussian channels are proposed. Using both binary and symbolic decoders on the second decoding stage of the convolutional codes are considered. Simulation results are indicated the higher performance characteristics of the proposed cascade schemes on majority decoders in comparison with clas- sical schemes based on the Viterbi algorithm and Reed-Solomon codes. A moderate increase in decoding delay during concatenation is revealed. It is determined by the absence of the need to use traditional two-dimensional concatenated structures.
Detector Requirements and Simulation Results for the EIC Exclusive, Diffractive and Tagging Physics Program using the ECCE Detector Concept (2022)

This article presents a collection of simulation studies using the ECCE detector concept in the context of the EIC's exclusive, diffractive, and tagging physics program, which aims to further explore the rich quark-gluon structure of nucleons and nuclei. To successfully execute the program, ECCE proposed to utilize the detecter system close to the beamline to ensure exclusivity and tag ion beam/fragments for a particular reaction of interest. Preliminary studies confirmed the proposed technology and design satisfy the requirements. The projected physics impact results are based on the projected detector performance from the simulation at 10 or 100 fb^-1 of integrated luminosity. Additionally, a few insights on the potential 2nd Interaction Region can (IR) were also documented which could serve as a guidepost for the future development of a second EIC detector.
Adequacy, Accuracy, Scalability, and Uncertainty of Architecture-based Software Reliability: Lessons Learned from Large Empirical Case Studies (2006)

Our earlier research work on applying architecture-based software reliability models on a large scale case study allowed us to test how and when they work, to understand their limitations, and to outline the issues that need future research. In this paper we first present an additional case study which confirms our earlier findings. Then, we present uncertainty analysis of architecture-based software reliability for both case studies. The results show that Monte Carlo method scales better than the method of moments. The sensitivity analysis based on Monte Carlo method shows that (1) small number of parameters contribute to the most of the variation in system reliability and (2) given an operational profile, components' reliabilities have more significant impact on system reliability than transition probabilities. Finally, we summarize the lessons learned from conducting large scale empirical case studies for the purpose of architecture-based reliability assessment and uncertainty analysis.
Rhenium(I) conjugates as tools for tracking cholesterol in cells (2022)

Cholesterol is vital to control membrane integrity and fluidity, but is also a precursor to produce steroid hormones, bile acids, and vitamin D. Consequently, altered cholesterol biology has been linked to many diseases, including metabolic syndromes and cancer. Defining the intracellular pools of cholesterol and its trafficking within cells is essential to understand both normal cell physiology and mechanisms of pathogenesis. We have synthesized a new cholesterol mimic (ReTEGCholestanol), comprising a luminescent rhenium metal complex and a cholestanol targeting unit, linked using a tetraethylene glycol (TEG) spacer. ReTEGCholestanol demonstrated favourable imaging properties and improved water solubility when compared to a cholesterol derivative, and structurally related probes lacking the TEG linker. A non-malignant and three malignant prostate cell lines were used to characterize the uptake and intracellular distribution of ReTEGCholestanol. The ReTEGCholestanol complex was effectively internalized and mainly localized to late endosomes/lysosomes in non-malignant PNT1a cells, while in prostate cancer cells it also accumulated in early endosomes and multivesicular bodies, suggesting disturbed cholesterol biology in the malignant cells. The ReTEGCholestanol is a novel imaging agent for visualizing endosomal uptake and trafficking, which may be used to define cholesterol related biology including membrane integration and altered lipid trafficking/processing.
Adolescent Neurology (2004)

<b>INTRODUCTION</b> Adolescence, Erikson’s fifth stage of man (Erikson 1965), is the phase of identity and role confusion. Teenage angst was epitomised by Adrian Mole whose analysis of his physical changes, acne, relationships, self-identity and growing independence in society, repeatedly clashed with his legal position as a child (Townsend 1982). Normal adolescence itself presents major challenges, but teenagers’ problems are greatly exacerbated by the additional burden of a neurological disorder. Their clinical care falls between paediatric and adult services, and their special problems can go unrecognized. Adult neurologists may see teenagers presenting either with new problems, or passed on from paediatric care with chronic conditions. Clinicians taking over teenagers’ care must not only assess their neurological condition, but also appreciate the influence of evolving physical, emotional, educational and social needs on their predicament. <b>TRANSITION</b> The recent UK National Service Framework for Children, Young People and Maternity Services, identified arrangements for transition
Noncoordinated expression of luteal cell messenger ribonucleic acids during human chorionic gonadotropin stimulation of the primate corpus luteum. (1993)

In nonfertile cycles, the absolute steroidogenic capacity of the primate corpus luteum, as reflected in the expression of messenger RNA (mRNA) for the progesterone biosynthetic enzymes cytochrome P450 cholesterol side-chain cleavage (P450SCC) and 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), progressively declines until luteal regression. Despite this progressive loss in luteal cell function, the elaboration of CG by the implanted blastocyst is able to prolong the functional lifespan of the corpus luteum. It was the purpose of this study to investigate the relationship between aging of the primate corpus luteum and the cellular mechanisms by which the decline in luteal cell function is arrested by CG. Corpora lutea were obtained from cynomolgus monkeys on days 11 or 16 of the luteal phase after a 7-day treatment period with increasing doses of human CG (hCG) given intramuscularly beginning on days 5 or 10. Corpora lutea were also obtained from control animals on days 5, 10, 11, and 16 of the luteal phase. Human CG treatment significantly (P < 0.05) elevated both serum progesterone and estradiol levels throughout the treatment period; however, progesterone production in animals treated with hCG late in the luteal phase (days 10-16) steadily declined after the third treatment day. Expression of mRNA for P450SCC and 3 beta-HSD was markedly stimulated (P < 0.05) by hCG treatment early in the luteal phase. However, 3 beta-HSD message levels in corpora lutea from animals treated with hCG on days 10-16 were not different from those of day-16 control corpora lutea, whereas P450SCC mRNA was only minimally stimulated. There was a dramatic (P < 0.05) increase in mRNA levels for the aromatase enzyme and low density lipoprotein receptor in animals given hCG in both the early and the late luteal phase. In conclusion, there appears to be a differential responsiveness of the primate corpus luteum to hCG stimulation dependent upon luteal age. The loss in responsiveness to hCG in terms of maintenance of mRNA levels is reflective of the inability of the late luteal phase corpus luteum for continued progesterone biosynthesis in the face of heightened luteotropic stimulation.
Falls Management: Detection and Prevention, using a Waist-mounted Triaxial Accelerometer (2007)

We describe a distributed falls management system capable of real-time falls detection in an unsupervised living context and remote longitudinal tracking of falls risk parameters using a waist-mounted triaxial accelerometer. A self-administrable falls risk assessment is used to facilitate falls prevention. A web-interface allows clinicians to monitor the status of individuals and track their compliance with exercise interventions. Early identification of increased falls risk allows targeted interventions to be promptly administered. Real-time detection of falls allows immediate emergency response protocols to be deployed, reducing morbidity and increasing the independence of the community-dwelling elderly community.
A Novel Protein Kinase B (PKB)/AKT-binding Protein Enhances PKB Kinase Activity and Regulates DNA Synthesis (2005)

Protein kinase B (PKB)/Akt reportedly plays a role in the survival and/or proliferation of cells. We identified a novel protein, which binds to PKB, using a yeast two-hybrid screening system. This association was demonstrated not only in vivo by overexpressing both proteins or by coimmunoprecipitation of the endogenous proteins, but also in vitro using glutathione S-transferase fusion proteins. Importantly, this protein specifically associates with the C terminus of PKB but not with other AGC kinases and enhances PKB phosphorylation and kinase activation without growth factor stimulation. Thus, we termed this Akt-specific binding protein APE (Akt-phosphorylation enhancer). Since APE-induced phosphorylation of PKB did not occur in cells treated with wortmannin or LY294002, APE itself is not a kinase but seems to enhance or prolong the phosphoinositide 3-kinase-dependent phosphorylation of PKB. In cells in which APE was suppressed by small interfering RNA, DNA synthesis was significantly reduced with suppression of PKB phosphorylation, suggesting a synergistic role of APE in PKB-induced proliferation. On the other hand, in cells overexpressing both PKB and APE, despite markedly increased basal phosphorylation of PKB, both DNA rereplication and subsequent Chk2 phosphorylation and apoptosis were seen, suggesting the involvement of APE in the regulation of cell cycling replication licensing. Taking these observations together, APE appears to be a novel regulator of PKB phosphorylation. Furthermore, the interaction between APE and PKB, possibly dependent on the expression levels of both proteins, may be a novel molecular mechanism leading to proliferation and/or apoptosis.
A nonvoxel‐based dose convolution/superposition algorithm optimized for scalable GPU architectures (2014)

The nonvoxel-based convolution method yielded substantial performance improvements over a generic GPU implementation, while maintaining accuracy as compared to a CPU computed ground truth dose distribution. Such an algorithm can be a key contribution toward developing tools for adaptive radiation therapy systems.
Two distinct quinoprotein amine oxidases are functioning in Aspergillus niger (1994)

Two distinct copper-quinoprotein amine oxidases (EC 1.4.3.6), AO-I and AO-II, were isolated from the soluble fraction of homogenized Aspergillus niger mycelia grown on butylamine medium. AO-I is a dimmer consisting of two 75 kDa subunits, while AO-II is a monomer of 80 kDa. Purified AO-I and AO-II show pink (490 nm) and yellow (420 nm) colors, respectively. The enzymes show comparable substrate specificity and sensitivity to inhibitors. Hexylamine, butylamine, benzylamine, tyramine and histamine are preferred substrates. Both enzymes are inhibited by substrate analogs, copper chelating agents, some alkaloids and carbonyl reagents. Enzymes labeled with p-nitrophenylhydrazine showed different absorption maxima at 465 and 440 nm for AO-I and AO-II, respectively, in neutral pH. These maxima were shifted to 585 nm under alkali conditions. Absorption and fluorescence spectra of synthesized model compound — topaquinone hydantoin p-nitrophenylhydrazone and labeled enzymes were in very good agreement, while PQQ p-nitrophenylhydrazone showed significant difference. After digestion by thermolysin, labeled cofactor containing peptides were purified using reverse phase HPLC and sequenced by Edman degradation, resulting typical topaquinone containing sequence, Asn-topa-Glu-Tyr, for AO-II and a noncofactor peptide, Val-Val-Ile-Glu-Pro, which contained topaquinone linked to γ-carboxyl of Glu, for AO-I. Cofactor structures were confirmed by mass spectrometry. N-Terminal amino acid sequences of AO-I and II were found to be different and peptide mapping showed some distinct patterns for both enzymes. A gene encoding AO-I has been cloned already and the second gene for AO-II is now under processing.