gebhart/patrepeval huggingface dataset:
Fertilitätsprotektion bei Mann-zu-Frau trans Personen: Früh an fertilitätsprotektive Maßnahmen denken (2020)

Zusammenfassung Wir stimmen dem in der Leitlinie genannten starken Konsens für Maßnahmen der Reproduktionsmedizin als wichtige Option zur Erfüllung des Kinderwunsches bei trans Personen uneingeschränkt zu. Informationen über diese Maßnahmen müssen Bestandteil von Behandlungen von trans Personen sein. Die geschlechtsangleichende Hormontherapie bei Mann-zu-Frau trans Personen hat jedoch einen negativen Einfluß auf die Spermatogenese. Der Erfolg der Fertilitätsprotektion bei Mann-zu-Frau trans Personen hängt stark von Qualität und Quantität der Spermien bzw. der spermatogonialen Stammzellen ab. Daher sollte die Beratung vor der geschlechtsangleichenden Hormontherapie stattfinden. Zu Beginn sollten eine ausführliche Anamnese, eine körperliche Untersuchung, eine Untersuchung von Serumhormonen (LH, FSH, Testosteron, Östradiol, AMH, Inhibin B) und ggf. eine Untersuchung des Ejakulats erfolgen. Zu den etablierten Methoden der Fertilitätsprotektion zählen Kryokonservierung von Spermien nach Ejakulation, Kryokonservierung von Spermien nach mikrochirurgischer testikulärer Spermienextraktion (mTESE) oder Spermienaspiration aus dem Nebenhoden (MESA) oder Kryokonservierung von spermatogonialen Stammzellen. Letztere sind auch möglich, wenn die geschlechtsangleichende Hormontherapie vor Beginn der Pubertät begonnen wird. Dies ist derzeit noch experimentell. Kryokonservierte Spermien können dazu verwendet werden, im Rahmen einer In-vitro-Fertilisation (IVF) und intrazytoplasmatischen Spermieninjektion (ICSI) mit Frauen eigene Kinder zu zeugen. Leihmutterschaft oder Eizellenspende ist in Deutschland derzeit nicht möglich. Wir wollen betonen, dass das Gespräch über fertilitätsprotektive Maßnahmen so früh wie möglich stattfinden muss, um den Erfolg zu garantieren und Absprachen zwischen den medizinischen Diszplinen zu ermöglichen. Das Ziel sind individuelle Lösungen, die für trans Personen finanzierbar, gangbar und operativ mit einfachen Mitteln zu erreichen sind.
UV- und Lichtschäden des Auges (2003)

Kaum eine Feststellung ist einleuchtender als diese: Licht ist notwendig für alles Leben auf der Erde. Für das Auge bedeutet Lichtexposition die Erzeugung des Sehreizes, also die Wahrnehmung unserer Welt. Licht kann jedoch bestimmte Strukturen und Funktionen des Auges verändern, ja, es kann sogar irreversible Schäden im Auge hervorrufen. Diese Beobachtung ist -anekdotische Berichte eingeschlossen — seit dem Altertum bekannt. Neu ist jedoch die systematische Erforschung von Lichtschäden und deren Verwendung in Laboratoriumsuntersuchungen als Modell zur molekularen Analyse von dystrophischen (hereditären) und degenerativen (induzierten) Augenerkrankungen. Sind also Lichtschäden des Auges relevant für die dermatologische Praxis?
Automotive MIMO Cellular Antenna Performance Comparison in an Over-The-Air Environment (2018)

This paper addresses the MIMO performance of automotive cellular antenna configurations as measured in an OTA (Over-The-Air) chamber. The OTA chamber measurement has been adopted by the cellular communications industry as a way to validate wireless devices such as smartphones, tablets and modems for RF compliance to the Carrier's network requirements. This performance assessment of an automotive cellular antenna in an OTA chamber is an approach to compare to wireless device performance and antenna verses antenna. The parameters that will be compared as a result of the OTA measurements are TRP (Total Radiated Power), TIS (Total Isotropic Sensitivity) and Data Throughput for given signal levels.
Parameter Estimation for a Jump Diffusion Model of Type 2 Diabetic Patients in the Presence of Unannounced Meals (2021)

Type 2 diabetes (T2D) has become one of the most often encountered metabolic disorders threatening the human health. Unannounced meal intake and irregular physical activity cause abrupt changes in the blood glucose concentrations. Therefore, a reliable and accurate algorithms that account for these sudden concentration changes constitute a crucial part of automated insulin pumps and dose guiders. To this end, we develop a stochastic jump diffusion model for T2D patients, reflecting the irregular frequency and uncertain amount of consumed carbohydrates. Moreover, we design a method—ombining particle Markov chain Monte Carlo and particle learning—to estimate the unknown parameters of this model, considering only continuous glucose monitoring data and amounts of injected insulin. Our approach is verified on synthetic and clinical data, demonstrating its ability to estimate the unknown parameters with a varying degree of accuracy.
A MATLAB-based graphical technique for amortization study of adjustable speed drives (2002)

Economic justification of electric drives is the primary reason for many applications. However, the cumbersome trial-and-error calculations necessary to present this aspect often leads to omission of the topic in electric drives courses. This paper presents a MATLAB-based program that generates plots of input power and shaft torque for variable-frequency operation of three-phase induction motors. Based on these graphs, an example is presented illustrating how a cost amortization study for an adjustable speed drive application can be presented with minimal effort and lecture time.
Work Volume and Strength Training Responses to Resistive Exercise Improve with Periodic Heat Extraction from the Palm (2011)

Body core cooling via the palm of a hand increases work volume during resistive exercise. We asked: (a) "Is there a correlation between elevated core temperatures and fatigue onset during resistive exercise?" and (b) "Does palm cooling between sets of resistive exercise affect strength and work volume training responses?" Core temperature was manipulated by 30-45 minutes of fixed load and duration treadmill exercise in the heat with or without palm cooling. Work volume was then assessed by 4 sets of fixed load bench press exercises. Core temperatures were reduced and work volumes increased after palm cooling (Control: Tes = 39.0 ± 0.1° C, 36 ± 7 reps vs. Cooling: Tes = 38.4 ± 0.2° C, 42 ± 7 reps, mean ± SD, n = 8, p < 0.001). In separate experiments, the impact of palm cooling on work volume and strength training responses were assessed. The participants completed biweekly bench press or pull-up exercises for multiple successive weeks. Palm cooling was applied for 3 minutes between sets of exercise. Over 3 weeks of bench press training, palm cooling increased work volume by 40% (vs. 13% with no treatment; n = 8, p < 0.05). Over 6 weeks of pull-up training, palm cooling increased work volume by 144% in pull-up experienced subjects (vs. 5% over 2 weeks with no treatment; n = 7, p < 0.001) and by 80% in pull-up naïve subjects (vs. 20% with no treatment; n = 11, p < 0.01). Strength (1 repetition maximum) increased 22% over 10 weeks of pyramid bench press training (4 weeks with no treatment followed by 6 weeks with palm cooling; n = 10, p < 0.001). These results verify previous observations about the effects of palm cooling on work volume, demonstrate a link between core temperature and fatigue onset during resistive exercise, and suggest a novel means for improving strength and work volume training responses.
Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters (2017)

Glycyrrhizic acid (GA) conjugates with methyl and ethyl esters of D-amino acids (D-Trp, D-Phe, D-Tyr, D-Val, D-Leu) have been synthesized by the activated esters method using mixtures of <i>N</i>-hydroxybenzotriazole or <i>N</i>-hydroxysuccinimide with <i>N</i>,<i>N</i>'-dicyclohexylcarbodiimide. GA conjugate with D-Trp ethyl ester exhibited antiviral activity against influenza viruses A/H3N2, A/H1N1/pdm09, A/H5N1, B (SI > 10-29), and HRSV (SI > 25). GA conjugate with D-Trp methyl ester inhibited influenza virus A/H1N1/pdm09 (SI > 30).
Sequence-based identification of inositol monophosphatase-like histidinol-phosphate phosphatases (HisN) in Corynebacterium glutamicum, Actinobacteria, and beyond (2017)

The kinetic data obtained for HisN from C. glutamicum, as an example for an IMPase-like HolPases, shows remarkable differences in enzyme properties as compared to HAD- or PHP-type HolPases. The six sequence motifs and the HMMs presented in this study can be used to reliably differentiate between IMPase-like HolPases and IMPase-like proteins with no such activity, with the potential to enhance current and future genome annotations. A phylogenetic analysis reveals that IMPase-like HolPases are not only present in Actinobacteria and plant but can be found in further bacterial phyla, including, among others, Proteobacteria, Chlorobi and Planctomycetes.
Clock Synchronization in Sensor Networks for Civil Security (2009)

Wireless sensor networks are widely deployed in security surveillance applications. Since most of these applications depend on having a common notion of time among the sensors, performing fine-grained clock synchronization is highly desirable. Most of the existing time synchronization approaches mainly focus on improving clock precisions and reducing energy consumption, while ignoring the effect of faults and attacks on system performance. In this thesis we show the importance of fine-grained clock synchronization and implement two of the most well-known synchronization schemes proposed in the literature. We compare these approaches considering the precision, cost and fault tolerance. Our implementations tolerate node failures and adopt newly joint nodes to the network. We also use the synchronized time to avoid message collisions by emulating TDMA-based scheduling in the synchronization protocol. Finally we describe some of the existing attacks against clock synchronization protocols and some of the possible solutions.
Palladium-Catalysed Synthesis of Dibenzo[de,g]quinolines. A Novel Approach to the B-Ring System of Aporphine-Related Heterocycles (1999)

Dibenzo[de,g]quinolines 5were formed by the palladium-catalysed heteroannulation of disubstituted alkynes and 1-iodo-10-(dimethylamino)phenanthrene (3c). Symmetric alkynes led to high levels of regioselectivity. These reactions constitute a new synthesis of the B-ring system of aporphine heterocycles.
Conventional and immunocolloidal gold electron microscopy of eight simian retroviruses closely related to human T-cell leukemia virus type I. (1986)

Simian retroviruses closely related to human T-cell leukemia virus type I (HTLV-I) were isolated from 8 species, examined by both conventional and thin section immunocolloidal gold electron microscopy, and compared with HTLV-I. Mature forms of simian viruses were found in extracellular aggregates and within cytoplasmic vacuoles. They were morphologically similar to each other and to HTLV-I. They consisted of a seemingly smooth envelope and a centrally located nucleoid. Their size varied considerably among species and also within the same species; this is characteristic of this group of retroviruses. No budding particles of simian viruses were observed. Thin section immunocolloidal gold electron microscopy using various human and simian sera showed that simian viruses were antigenically related to each other and to HTLV-I. One drawback of this otherwise very useful technique was the difficulty in identifying virions because of the poor preservation of their fine structure by fixation with glutaraldehyde alone. This was overcome by using materials prepared for conventional electron microscopy, in which virions showed weak but specific reactions with gold particles after deosmification and antigen restoration with sodium metaperiodate.
Combining 2D And 3D Face Images For Reliable Identity Verification (2005)

Publication in the conference proceedings of EUSIPCO, Antalya, Turkey, 2005
Combined use of zoledronic acid and 153Sm-EDTMP in hormone-refractory prostate cancer patients with bone metastases (2007)

Zoledronic acid treatment does not influence (153)Sm-EDTMP skeletal uptake. Combined treatment is feasible and safe.
Effect of Variable Emittance Coatings on the Operation of a Miniature Loop Heat Pipe (2005)

As the size of spacecraft shrink to accommodate small and more efficient instruments, smaller launch vehicles, and constellation missions, all subsystems must also be made smaller. Under NASA NRA 03‐OSS‐02, Space Technology‐8 (ST 8), NASA Goddard Space Flight Center and Jet Propulsion Laboratory jointly conducted a Concept Definition study to develop a miniature loop heat pipe (loop heat pipe) thermal management system design suitable for future small spacecraft. The proposed loop heat pipe thermal management system consists of a miniature loop heat pipe (LHP) and deployable radiators that are coated with variable emittance coatings (VECs). As part of the Phase A study and proof of the design concept, variable emittance coatings were integrated with a breadboard miniature loop heat pipe. The entire system was tested under vacuum at various temperature extremes and power loads. This paper summarizes the results of this testing and shows the effect of the VEC on the operation of a miniature loop heat pipe.
MFAP4: a candidate biomarker for hepatic and pulmonary fibrosis? (2016)

MFAP4 is not elevated in sera of patients with pulmonary fibrosis or bleomycin treated mice with pulmonary fibrosis. This may be due to different pathogenic mechanisms of liver and lung fibrogenesis. MFAP4 seems to be useful as serum biomarker for hepatic but not for lung fibrosis.
Synthesis and Characterization of Poly(pyridinium triflate)s with Alkyl and Aromatic Spacer Groups for Potential Use as Nonlinear Optic Materials (2005)

A series of poly(pyridinium triflate)s with alkyl and aromatic spacer groups were prepared by ring transformation polymerizations between various pyrylium triflates and diamines. The polymers are soluble in polar aprotic solvents and form tough, clear, flexible films. These novel polymers were characterized by IR, NMR, UV, DSC, TMA, and TGA. The polymers were thermally stable to 340 °C under nitrogen, and had softening points that ranged from 151 to 255 °C. Thin films were shown to display electrostrictive behavior in the presence of an applied electric field, with the amount of transverse strain being proportional to the concentration of charge in the polymer.
Interaction of Spatiotemporal Wave Structures in Nonlinear Optical Resonators: New Routes in Optical Turbulence (1992)

Summary not available at press time.
Efficient Synthesis of α-Chloro Ketones via Reaction of Organometallic Reagents with N-Methoxy-N-Methylchloroacetamide (1996)

A simple, high yielding synthesis of α-chloro ketones is described, involving acylation of Grignard and organolithium reagents with N-methoxy-N-methylchloroacetamide. The efficiency of the process is further enhanced by recycling N,O-dimethylhydroxylamine.
Combined STM/STS, TEM/EELS investigation of CNx‐SWNTs (2008)

Abstract Nitrogen doped single‐walled carbon nanotubes (CN x ‐SWNTs) were successfully synthesized by vaporizing a C:Ni/Y target by a CO 2 continuous laser under a nitrogen atmosphere. The as‐grown nanotubes were investigated by combining TEM/EELS and STM/STS techniques. According to TEM observations, the tubes are mostly single‐walled and few defects are found. Local chemical characterization was performed by EELS analysis, which proves the presence of nitrogen in both individual tubes and SWNTs bundles and indicates a nitrogen concentration around 1 at.%. STM observations of CN x ‐SWNTs have been then undertaken and atomic resolution images were obtained. First STM analyses of these nanotubes show some defects which have never been observed in pure carbon nanotubes before. (© 2008 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
The Clinical Course of Left Ventricular Hypertrophy in Dialysis Patients (1990)

To determine the clinical and echocardiographic outcome of left ventricular hypertrophy a prospective study was undertaken of 104 nondiabetic dialysis patients without dilated cardiomyopathy, who were followed for 3-5 years. 33% of patients had normal echocardiogram, 41% mild and 27% severe hypertrophy (left ventricular wall thickness greater than or equal to 1.4 cm in diastole). In the first 2 groups 16% progressed to severe hypertrophy, 23% were admitted with congestive heart failure after starting dialysis therapy, and 2-year cumulative survivals were 97 and 85%. In the group with severe hypertrophy 88% already had severe hypertrophy on starting dialysis therapy, it was persistent in 87%, 50% were admitted at least once with congestive heart failure, and the 2-year cumulative survival was 53%. 71% of those who died in the severe group died from cardiac or cerebrovascular causes compared to none of those with normal echocardiogram, which accounted for the significantly worse (p = 0.001) survival. We conclude that severe left ventricular hypertrophy occurs frequently in dialysis patients, is often present at the start of end-stage renal disease therapy, is persistent, may predispose to congestive heart failure, and is associated with a high mortality.
Signal Transduction of PACAP and GLP-1 in Pancreatic β Cellsa (2006)

PACAP and GLP-1 depolarize pancreatic beta cells and stimulate insulin secretion in the presence of glucose. Depolarization occurs through at least two distinct mechanisms: (1) closure of ATP-sensitive K+ channels, and (2) activation of nonselective cation channels (NSCCs). Under physiological conditions the NSCCs carry a predominantly Na(+)-dependent current. The current may also have a Ca2+ component, but this remains to be determined. Acting together, these two signaling systems reinforce each other and serve to promote membrane depolarization, a rise of [Ca2+]i, and exocytosis of insulin-containing secretory granules. The NSCCs in beta cells are dually regulated by intracellular cAMP and [Ca2+]i. In view of this dual regulation, it appears likely that NSCC channel activation results from signaling events occurring not only at the plasma membrane (gating of channels by cAMP; protein kinase A-mediated phosphorylation of channels) but also at intracellular sites (mobilization of calcium stores by an as yet to be determined process). It is noteworthy that activation of NSCCs has also been reported following stimulation of beta-cells with maitotoxin, or after depletion of intracellular Ca2+ stores. Therefore, the possibility arises that PACAP, GLP-1, and maitotoxin all act on the same types of ion channels in these cells, and that these channels are sensitive to alterations in the content of intracellular calcium. FIGURE 6 summarizes our current knowledge concerning the properties of the PACAP and GLP-1 signaling systems as they pertain to the regulation of NSCCs and intracellular calcium homeostasis in the beta cell. Given that PACAP and GLP-1 are proven to be exceptionally potent insulin secretagogues, it is of considerable interest to determine their usefulness as blood glucose-lowering agents. Initial evaluations of the therapeutic effectiveness of GLP-1 indicate a role for this peptide in the treatment of NIDDM, and also possibly insulin-dependent diabetes mellitus (IDDM). A very attractive feature of such a strategy is the demonstrated lack of hypoglycemic side effects attendant to administration of GLP-1 to diabetic subjects. These observations reinforce the notion that peptides of the PACAP/glucagon/VIP family represent important pharmacological tools for use in experimental therapeutics.
Cerebral infarction due to moyamoya disease in young adults. (1988)

Moyamoya disease was diagnosed as the cause of cerebral infarction in eight young adults (seven women, one man), aged 17-40 (mean 33) years. All had angiographic abnormalities characteristic of moyamoya disease. Single-photon emission tomography showed bilateral carotid circulation hypoperfusion and posterior circulation hyperemia in all seven patients with regional cerebral blood flow studies. All seven women had used oral contraceptives before cerebral infarction. Four patients were treated medically; one died of a second cerebral infarction 9 months after diagnosis. Four patients underwent superficial temporal-to-middle cerebral artery anastomosis; they did well. Moyamoya disease should be included in the differential diagnosis of cerebral infarction as well as intracranial hemorrhage in young adults, particularly women. A possible relation between moyamoya disease and oral contraceptive use deserves investigation.
Chemoprevention strategies in the prostate: an overview. (2002)

Chemoprevention is the administration of agents (drugs, biologics, and nutrients) to prevent induction, inhibit, or delay the progression of cancers. Prostate cancer is an important target for chemoprevention because of its long latency and high prevalence. The development of rational chemopreventive strategies requires knowledge of the mechanisms of prostate carcinogenesis and identification of agents that interfere with these mechanisms. Because of the long time period for prostate carcinogenesis and the large size of the cohort required for an evaluable study, identification and characterization of early intermediate biomarkers and their validation as surrogate endpoints for cancer incidence are essential for chemopreventive agent development. Finally, suitable populations with appropriate risk factors, including the presence of premalignant lesions and genetic predispositions, need to be well characterized for future chemopreventive interventions.
Reference-pulses neutron/gamma-ray pulse shape discrimination in liquid scintillators for deposited neutron energies from 200 keV (2010)

A hybrid pulse shape discrimination (PSD) method is presented that combines a charge-integration PSD method with a reference-pulses PSD method. The reference-pulses PSD method uses detailed knowledge of the average, energy-dependent detector response to radiation. To obtain the reference pulses, a large number of neutron and gamma-ray pulses were averaged in several pulse height regions. The reference neutron and gamma-ray pulses were then used in the new PSD method for the classification of `known' measured pulses. The reference-pulses PSD method was applied below 70 keVee (keV electron equivalent), whereas the standard charge-integration PSD method was used above 70 keVee. This new hybrid PSD method proves to be more accurate than the standard charge-integration PSD method for classification of neutrons and gamma rays. Specifically, the improvement is approximately 30% for neutrons between 20 and 30 keVee (corresponding to approximately 50 and 225 keV neutron energy deposited). For this pulse height bin, approximately 72% of the neutrons were correctly classified by the hybrid PSD method. The average number of correctly classified neutrons is approximately 88% for the hybrid PSD method between 20 and 100 keVee (150 and 670 keV neutron energy deposited) as opposed to 83% for the charge-integration PSD method.