gebhart/patrepeval huggingface dataset:
The Small Fibrinopeptide Bβ15–42 as Renoprotective Agent Preserving the Endothelial and Vascular Integrity in Early Ischemia Reperfusion Injury in the Mouse Kidney (2014)

Disruption of the renal endothelial integrity is pivotal for the development of a vascular leak, tissue edema and consequently acute kidney injury. Kidney ischemia amplifies endothelial activation and up-regulation of pro-inflammatory mechanisms. After restoring a sufficient blood flow, the kidney is damaged through complex pathomechanisms that are classically referred to as ischemia and reperfusion injury, where the disruption of the inter-endothelial connections seems to be a crucial step in this pathomechanism. Focusing on the molecular cell-cell interaction, the fibrinopeptide Bβ15-42 prevents vascular leakage by stabilizing these inter-endothelial junctions. The peptide associates with vascular endothelial-cadherin, thus preventing early kidney dysfunction by preserving blood perfusion efficacy, edema formation and thus organ dysfunction. We intended to demonstrate the early therapeutic benefit of intravenously administered Bβ15-42 in a mouse model of renal ischemia and reperfusion. After 30 minutes of ischemia, the fibrinopeptide Bβ15-42 was administered intravenously before reperfusion was commenced for 1 and 3 hours. We show that Bβ15-42 alleviates early functional and morphological kidney damage as soon as 1 h and 3 h after ischemia and reperfusion. Mice treated with Bβ15-42 displayed a significantly reduced loss of VE-cadherin, indicating a conserved endothelial barrier leading to less neutrophil infiltration which in turn resulted in significantly reduced structural renal damage. The significant reduction in tissue and serum neutrophil gelatinase-associated lipocalin levels reinforced our findings. Moreover, renal perfusion analysis by color duplex sonography revealed that Bβ15-42 treatment preserved resistive indices and even improved blood velocity. Our data demonstrate the efficacy of early therapeutic intervention using the fibrinopeptide Bβ15-42 in the treatment of acute kidney injury resulting from ischemia and reperfusion. In this context Bβ15-42 may act as a potent renoprotective agent by preserving the endothelial and vascular integrity.
Recombinant TAT-BMI-1 fusion protein induces ex vivo expansion of human umbilical cord blood-derived hematopoietic stem cells (2017)

Transplantation of hematopoietic stem cells (HSCs) is a well-established therapeutic approach for numerous disorders. HSCs are typically derived from bone marrow or peripheral blood after cytokine-induced mobilization. Umbilical cord blood (CB) represents an appealing alternative HSC source, but the small amounts of the individual CB units have limited its applications. The availability of strategies for safe ex vivo expansion of CB-derived HSCs (CB-HSCs) may allow to extend the use of these cells in adult patients and to avoid the risk of insufficient engraftment or delayed hematopoietic recovery.Here we describe a system for the ex vivo expansion of CB-HSCs based on their transient exposure to a recombinant TAT-BMI-1 chimeric protein. BMI-1 belongs to the Polycomb family of epigenetic modifiers and is recognized as a central regulator of HSC self-renewal. Recombinant TAT-BMI-1 produced in bacteria was able to enter the target cells via the HIV TAT-derived protein transduction peptide covalently attached to BMI-1, and conserved its biological activity. Treatment of CB-CD34+ cells for 3 days with repeated addition of 10 nM purified TAT-BMI-1 significantly enhanced total cell expansion as well as that of primitive hematopoietic progenitors in culture. Importantly, TAT-BMI-1-treated CB-CD34+ cells displayed a consistently higher rate of multi-lineage long-term repopulating activity in primary and secondary xenotransplants in immunocompromised mice. Thus, recombinant TAT-BMI-1 may represent a novel, effective reagent for ex vivo expansion of CB-HSC for therapeutic purposes.
[Uterine papillary serous carcinoma and papillary endometrial carcinoma: analysis of clinical biological behaviors of 56 cases]. (1996)

The presence of papillary features in endometrial carcinoma is an important prognostic indicator. The prognosis of PEC is better than UPSC, but worse than AC.
The effects of interconnect process and snapback voltage on the ESD failure threshold of NMOS transistors (1988)

The electrostatic discharge (ESD) failure threshold of NMOS transistors in a shelf-aligned TiSi/sub 2/ process has been identified to be sensitive to both interconnect processes and device structures. For a consistently good ESD protection level, there is a maximum limit of TiSi/sub 2/ thickness formed on a shallow junction. The thickness is less than that required to ensure a low junction leakage current. The effect of contact processes on ESD is also studied. Both the size and quantity of contacts on the source-drain area of NMOS transistors have important effects on the ESD failure threshold of the NMOS transistor. The ESD failure threshold voltage an NMOS transistor is strongly correlated with the snapback voltage of its lateral parasitic bipolar transistor. The ESD pass voltage or the highest current that an NMOS transistor can withstand is a decreasing function of its parasitic bipolar snapback voltage. This finding explains why an abrupt junction device has a higher ESD failure threshold voltage than a graded-junction device. The gate potential of an NMOS transistor also has important effects on its failure threshold voltage.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The number of long-lasting functional memory CD8+ T cells generated depends on the nature of the initial nonspecific stimulation (2002)

The mechanism of generation of memory cytotoxic T cells (CTL) following immunization remains controversial. Using tumor protection and IFN-gamma ELISPOT assays in mice to detect functional CTL, we show that the initial effector CTL burst size after immunization is not directly related to the amount of functional memory CTL formed, suggesting that memory CTL are unlikely to arise stochastically from effector CTL. Induction of MHC class II-restricted T helper cells at the time of immunization by inclusion of a T helper peptide or protein in the immunogen, is necessary to generate memory CTL, although no T helper cell induction is required to generate effector CTL to a strong MHC class I-binding peptide. Host protective T cell memory correlates with the number of CTL epitope responsive IFN-gamma-secreting memory T cells as measured in an ELISPOT assay at the time of tumor challenge. We conclude that a different antigen presenting environment is required to induce long-lasting functional memory CTL, and non-cognate stimulation of the immune system is essential to allow generation of a long-lasting host protective memory CTL response.
Electrochromic Devices Based on Binuclear Mixed Valence Compounds Adsorbed on Nanocrystalline Semiconductors (2003)

A series of cyano-bridged binuclear mixed valence complexes of the general formula M-Ru(III)(NH(3))(4)pyCOOH [pyCOOH = isonicotinic acid; M = cis-Ru(bpy)(2)(CN)(2), 1 (bpy = 2,2' bipyridine); trans-Ru(py)(4)(CN)(2), 2 (py = pyridine); [Ru(CN)(6)](4)(-), 3; [Fe(CN)(6)](4)(-), 4] have been prepared and anchored through the carboxylic function to nanocrystalline TiO(2) or SnO(2) electrodes. The complexes display a reversible electrochromic behavior in the range of applied potential from -0.5 to +0.5 V, versus SCE. Tuning of the electronic transitions in the visible and near-infrared spectral regions is achieved through changes of the solvent and of the cyano-bridged metal moiety M.
AMBER: Assessment of Metagenome BinnERs (2018)

Reconstructing the genomes of microbial community members is key to the interpretation of shotgun metagenome samples. Genome binning programs deconvolute reads or assembled contigs of such samples into individual bins. However, assessing their quality is difficult due to the lack of evaluation software and standardized metrics. Here, we present Assessment of Metagenome BinnERs (AMBER), an evaluation package for the comparative assessment of genome reconstructions from metagenome benchmark datasets. It calculates the performance metrics and comparative visualizations used in the first benchmarking challenge of the initiative for the Critical Assessment of Metagenome Interpretation (CAMI). As an application, we show the outputs of AMBER for 11 binning programs on two CAMI benchmark datasets. AMBER is implemented in Python and available under the Apache 2.0 license on GitHub.
SUperposition Noisy Network Coding (2011)

We present a superposition coding scheme for communication over a network, which combines partial decode and forward with noisy network coding. This hybrid scheme is termed as superposition noisy network coding. The scheme is designed and analyzed for a single relay channel, single source multicast network and multiple source multicast network. The achievable rate region is determined for each case. The special cases of Gaussian single relay channel and two way relay channel are analyzed for superposition noisy network coding. The achievable rate of the proposed scheme is higher than the existing schemes of noisy network coding and compress-forward.
Who Owns the Air: Unscrambling the Satellite Viewing Rights Dilemma (1986)

ing satellite signals.It will then review how the signals were protected under the Act before the 1984 amendments, outline the protections and exemptions prescribed by Congress in
Road Safety in South Asia - Opportunities for Shared Regional Initiatives (2020)

Trends in road crash fatalities over the past four to fi ve decades show clear differences between high-income countries and low and middle-income countries, and between regions of the world, though historical data for this are limited and subject to varying regional classifications. Since the World Health Organization (WHO) and the World Bank Group (WBG) jointly published the World Report on Road Traffic Injury Prevention in 2004 the focus of global road safety initiatives has been at the country level (Peden et al. 2004). However, the importance of regional contexts and country relationships within regions is generally well acknowledged. This is most apparent in transport infrastructure investment programs and regulatory considerations arising within integrated regional trade blocs and logistics chains. There is also an increasing recognition that policy initiatives at the regional level, in vehicle and infrastructure safety for instance, can complement and strengthen country road safety strategies and programs. This report considers these strategic issues in the context of the South Asia region and addresses related regional road safety challenges, investment priorities, opportunities for shared regional initiatives, and the way forward over the next decade to 2030.
Structure‐Based Calculations of the Optical Spectra of the LH2 Bacteriochlorophyll‐Protein Complex from Rhodopseudomonas acidophila (1996)

Abstract— The molecular structure of the light‐harvesting complex 2 (LH2) bacteriochlorophyll‐protein antenna complex from the purple non‐sulfur photosynthetic bacterium Rhodopseudomonas acidophila , strain 10050 provides the positions and orientations of the 27 bacteriochlorophyll (BChl) molecules in the complex. Our structure‐based model calculations of the distinctive optical properties (absorption, CD, polarization) of LH2 in the near‐infrared region use a point‐monopole approximation to represent the BChl Q y transition moment. The results of the calculations support the assignment of the ring of 18 closely coupled BChl to B850 (BChl absorbing at 850 nm) and the larger diameter, parallel ring of 9 weakly coupled BChl to B800. All of the significantly allowed transitions in the near infrared are calculated to be perpendicular to the C9 symmetry axis, in agreement with polarization studies of this membrane‐associated complex. To match the absorption maxima of the B800 and B850 components using a relative permittivity (dielectric constant) of 2.1, we assign different site energies (12 500 and 12260 cm −1 , respectively) for the Q y transitions of the respective BChl in their protein binding sites. Excitonic coupling is particularly strong among the set of B850 chromophores, with pairwise interaction energies nearly 300 cm between nearest neighbors, comparable with the experimental absorption bandwidths at room temperature. These strong interactions, for the full set of 18 B850 chromophores, result in an excitonic manifold that is 1200 cm −1 wide. Some of the upper excitonic states should result in weak absorption and perhaps stronger CD features. These predictions from the calculations await experimental verification.
Concentration dependence of Ge segregation during the growth of a SiGe buried layer (1993)

X-ray photoelectron spectroscopy (XPS) measurements of a series of films with varying x and cap thicknesses were made to determine the Ge profile in both thin Si cap layers and the Si1−xGex buried layers grown at 500 °C. The inelastic mean free path of 267 eV electrons through a silicon overlayer was measured to be 1.2 nm. The Ge profile was inferred by simulating the surface segregation process using a two-state exchange mechanism, and comparing the expected XPS spectra to the obtained data. The resulting model predicts a floating surface layer rich in Ge during the growth of the Si1−xGex layer and the Si cap that results in distortion of both interfaces of the buried layer. The interface formed upon beginning the growth of the buried Si1−xGex layer can be wide, and estimates of the width of the ‘‘leading’’ interface range from ∼20 monolayers (MLs) for an x=0.05 layer, and ∼10 MLs for an x=0.1 layer grown at 500 °C.
Machine Learning Algorithms for Recommending Design Methods (2014)

Every year design practitioners and researchers develop new methods for understanding users and solving problems. This increasingly large collection of methods causes a problem for novice designers: How does one choose which design methods to use for a given problem? Experienced designers can provide case studies that document which methods they used, but studying these cases to infer appropriate methods for a novel problem is inefficient. This research addresses that issue by applying techniques from content-based and collaborative filtering to automatically recommend design methods, given a particular problem. Specifically, we demonstrate the quality with which different algorithms recommend 39 design methods out of an 800+ case study dataset. We find that knowing which methods occur frequently together allows one to recommend design methods more effectively than just using the text of the problem description itself. Furthermore, we demonstrate that automatically grouping frequently co-occurring methods using spectral clustering replicates human-provided groupings to 92% accuracy. By leveraging existing case studies, recommendation algorithms can help novice designers efficiently navigate the increasing array of design methods, leading to more effective product design.
Remote control of a mobile robot using distance-based reflective force (2004)

In this paper, a real-time obstacle avoidance method is discussed for a remote mobile robot controlled by a teleoperator. The method enables the remote user to drive the mobile robot without collisions. It consists of a real-time environment modeling algorithm using ultrasonic sensors, and a mobile robot control algorithm for obstacle avoidance. The former solves the limitations of the ultrasonic sensors such as noise sensitivity, poor directionality, and specular reflection for obtaining more accurate sensor data. Then the latter conducts wall or center following implemented by a fuzzy controller for obstacle avoidance using the environment model obtained by the previous algorithm. The command for obstacle avoidance is actually applied as a reflective force using a haptic device such as a force feedback joystick. The remote mobile robot, ROBHAZ-DT(RoBot in HAZardous environment-Double Track) developed by KIST(Korea Institute of Science and Technology), is employed as the mobile robot model. The normal and the maximum speed of the ROBHAZ-DT are 3.1 km/h and 7.2 km/h, respectively. The weight of the robot is 50 kg. Simulations with the ROBHAZ-DT model are carried out to verify the performance of the proposed method.
Constrained Dynamic Matrix Control for a Boiler-Turbine Unit (2006)

A boiler-turbine unit is a typical multi-input multi-output (MIMO) industrial control system in power plant, which has nonlinear and couple characteristics. In this paper, a constrained dynamic matrix control (DMC) algorithm is designed for a nonlinear multivariable boiler-turbine unit with hard input constraints. Firstly an improved unconstrained DMC algorithm based on step response model for a single-input single-output (SISO) integrating process is proposed. It is shown that the proposed algorithm is more effective than conventional DMC and can also be extended to MIMO systems with integrating subsystems and input/output constraints. A 1-norm objective function is presented and the control actions can be obtained using linear programming online. Simulation results show that the designed control system has good tracking property and disturbance rejection ability without steady state offset while the control actions satisfy the constraints
Active Sites in a Heterogeneous Organometallic Catalyst for the Polymerization of Ethylene (2021)

Heterogeneous derivatives of catalysts discovered by Ziegler and Natta are important for the industrial production of polyolefin plastics. However, the interaction between precatalysts, alkylaluminum activators, and oxide supports to form catalytically active materials is poorly understood. This is in contrast to homogeneous or model heterogeneous catalysts that contain resolved molecular structures that relate to activity and selectivity in polymerization reactions. This study describes the reactivity of triisobutylaluminum with high surface area aluminum oxide and a zirconocene precatalyst. Triisobutylaluminum reacts with the zirconocene precatalyst to form hydrides and passivates -OH sites on the alumina surface. The combination of passivated alumina and zirconium hydrides formed in this mixture generates ion pairs that polymerize ethylene.
Low-jitter fractional spread-spectrum clock generator using fast-settling dual charge-pump technique for Serial-ATA application (2009)

A low-jitter fractional spread-spectrum clock generator (SSCG) by utilizing a fast-settling dual charge-pump (CP) technique has been developed for Serial-ATA (SATA) applications. The proposed fast-settling dual CP technique not only reduced a design area but also shortened settling-time by controlling the CP operation sequence in an SSCG settling period. A multi-modulus divider using differential dynamic flip-flops was applied to our SSCG to reduce the design area, power consumption, and jitter. The proposed SSCG for SATA generation I was fabricated in a 0.13 mum CMOS process. The settling-time was 3.91 mus faster than that of a conventional SSCG, 8.11 mus. The random jitter and total jitter in 250 cycles at 1.5 GHz were 2.7 psrms and 3.3 psrms, respectively. The EMI reduction that meets SATA specification was 10.0 dB. The design area and the power consumption were 300 times 700 mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and 18 mW, respectively.
Typing of strains of Staphylococcus aureus by Western Blot analysis of culture supernates (1986)

Extracellular proteins produced by Staphylococcus aureus strains were examined by Western Blot analysis with blood donor plasma as a source of antibodies. Comparison of epidemiologically related strains showed strong concordance between plot pattern and phage type.
Some Potentialities of Optical Masers (1962)

This paper, originally presented at the 1961 WESCON Convention, is intended as an introduction to the principles and possible applications of the optical maser. Very little prior knowledge on the part of the reader is assumed. The intent is to acquaint him with these exciting new devices with the hope that he, in turn, will discover applications not foreseen by the author. The methods of generating coherent radiation, of focussing it, and of collimating it into tight beams are described. The use of lasers for communication is explored, and certain medical and other applications are suggested.
IPTV deployment:trigger for advanced network services ! (presentation) (2006)

low delay, high availability -conferencing (IP telephony, video conferencing)low delay and jitter -home management (automation, security)high availability
A Husband for Lady Bridget (2003)

This chapter describes the potential husband for Oxford's second daughter, Lady Bridget. The prospective bridegroom was Francis Norris, the grandson of Baron Henry, Lord Norris (or Norreys) of Rycote. Some time in May or June 1599, Bridget Vere, aged fifteen, married Francis Norris, who would turn twenty on 6 July. The chapter also details the suit filed by Judith Ruswell on 28 April for some £500 in reference to her husband's service to Oxford twenty years previously as ‘Master of his Wardropp’. Like Julian Penn and so many others, Judith Ruswell claimed that Oxford had failed to pay his debt.
Differential precoder IC modules for over-20-Gbit/s optical duobinary transmission systems (2003)

This paper reports on precoder IC modules for 20 Gbit/s and 40 Gbit/s optical duobinary transmission systems that uses production-level 0.2 /spl mu/m gate-length GaAs MESFETs. The transmitter using the precoder module generates fully encoded 20 Gbit/s optical duobinary signals for the first time and achieves a high receiver sensitivity of -28.6 dBm.
Ad Libitum Choline Intake in Healthy Individuals Meets or Exceeds the Proposed Adequate Intake Level (2020)

Choline is an essential nutrient for humans that is used to synthesize membrane phospholipids and the neurotransmitter acetylcholine. Betaine, a metabolite of choline, functions as a methylgroup donor in the conversion of homocysteine to methionine, and is important for renal function. Accurate analysis of choline intake was previously not possible because the choline content of most foods was not known. Using new and recently published data on the concentrations of choline in common foods, we measured the choline content of diets consumed ad libitum by healthy adult volunteers housed in a clinical research center and compared these with estimates of choline intake derived from 3-d food records kept by subjects immediately before study enrollment. Mean choline intake in this subject population met or slightly exceeded the current Adequate Intake (AI) of 7 mg/(kg · d) set by the Institute of Medicine. Men and women consumed similar amounts of choline per day (8.4 and. 6.7 mg/kg, respectively; P = 0.11). Choline intakes estimated from the 3-d food records were significantly lower than this (when expressed as mg/kg, or as total mg, but not when normalized to energy intake), suggesting underreporting of food intake. Intake of betaine, which may spare choline utilization as a methylgroup donor, was 5.3 mg/(kg · d) in men and 4.7 mg/(kg · d) in women. Intake of folate, vitamin B-12, and methionine + cysteine, were similar and sufficient in all subjects. The current recommended AI for choline seems to be a good approximation of the actual intake of this nutrient.
Role of Sec16p in the formation of COPII-coated ER to Goldi transport vesicles in Saccharomyces cerevisiae (1997)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.