gebhart/patrepeval huggingface dataset:
Improved treatment of vulvovaginal candidiasis with fluconazole plus probioticLactobacillus rhamnosusGR-1 andLactobacillus reuteriRC-14 (2009)

This novel finding of probiotic lactobacilli augmenting the cure rate of yeast vaginitis, not only offers an alternative approach to a highly prevalent condition that adversely affects the quality of life of women around the world, but also raises the question of how this combination works.
Addition of dihalocarbenes to 1-germacyclopent-3-enes and to 1,1,3,4-tetramethyl-1-silacyclopent-3-ene (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAddition of dihalocarbenes to 1-germacyclopent-3-enes and to 1,1,3,4-tetramethyl-1-silacyclopent-3-eneDietmar Seyferth, Theodore F. Jula, David C. Mueller, Pierre Mazerolles, Georges Manuel, and Francoise ThoumasCite this: J. Am. Chem. Soc. 1970, 92, 3, 657–666Publication Date (Print):February 1, 1970Publication History Published online1 May 2002Published inissue 1 February 1970https://pubs.acs.org/doi/10.1021/ja00706a038https://doi.org/10.1021/ja00706a038research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Proton exchanged waveguides for surface acoustic waves on LiNbO3 (1987)

For the first time waveguides for surface acoustic waves (SAW) have been fabricated by exchanging Li+ ions with protons on Y-cut LiNbO3 substrates. Different waveguiding structures were investigated. The influence of the proton source dilution, the annealing or the Ti prediffusion on the SAW velocity, and the parameters of the SAW waveguides have been studied.
Reply to Professor Harsanyi (1982)

Reply to Harsanyi, J. C. 1982. Comment—Subjective probability and the theory of games: comments on Kadane and Larkey's paper. Management Sci. 28 (2) 120–124.
The electronics system of the ALFA forward detector for luminosity measurements in ATLAS (2012)

The ATLAS Forward Detectors for Measurement of Elastic Scattering and Luminosity (ALFA) have been fully installed during the 2010–2011 winter LHC shutdown. ALFA consists of 8 mini tracking detectors made of 20 planes of scintillating fibers placed in Roman Pot units near the beam and 240 m away on both sides of the interaction point. The front-end electronics sit directly on top of the PMTs and has been designed to facilitate the connectivity to the ATLAS counting room. The full system consisting of the detectors units, the control electronics and the connections to the ATLAS TTC, TDAQ and DCS systems has been successfully tested.
Performance comparison of two window flow control schemes with admission delay (2002)

A performance comparison of two window flow control schemes, e.g., the pacing and the sliding window protocols, over a virtual route network with an input queue included is presented. The input queue is introduced into the model to describe the waiting system where messages prevented from entering the network are stored in a first-come first-served manner. The model is shown to lead to a Markovian queuing system, which is solved through approximations by using the appropriate solution methods. The results indicate that the optimum window size that maximizes the power criterion is empirically determined and becomes nearly twice the number of hops (nodes of the network). It is also indicated that, although the average number of messages in the network is higher for the pacing window case, when the input queue delay is taken into consideration the overall performance of the pacing window protocol is better than that of the sliding window.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Evaluation of l‐Tryptophan Derivatives as Inhibitors of the l‐Type Amino Acid Transporter LAT1 (SLC7A5) (2022)

A series of derivatives of the substrate amino acid l-tryptophan have been investigated for inhibition of the L-type amino acid transporter LAT1 (SLC7A5), which is an emerging target in anticancer drug discovery. Of the four isomeric 4-, 5-, 6-, or 7-benzyloxy-l-tryptophans, the 5-substituted derivative was the most potent, with an IC<sub>50</sub> of 19 μM for inhibition of [<sup>3</sup> H]-l-leucine uptake into HT-29 human colon carcinoma cells. The replacement of the carboxy group in 5-benzyloxy-l-tryptophan by a bioisosteric tetrazole moiety led to a complete loss in potency. Likewise, the corresponding tetrazolide derived from l-tryptophan itself was found to be neither a substrate nor an inhibitor of the transporter. Increasing the steric bulk at the 5-position, while reasonably well tolerated in some cases, did not result in an improvement in potency. At the same time, none of these derivatives was found to be a substrate for LAT1-mediated transport.
Room-temperature discotic cholesteric and nematic phases: influence of 3,7-dimethyloctane peripheral chain on the molecular self-assembly of radial polyalkynylbenzene (2011)

A series of novel radial symmetrical and non-symmetrical polyalkynylbenzene-based chiral and achiral disc-shaped materials with respectively five and six 3,7-dimethyloctyl peripheral aliphatic chains are synthesised. The symmetrical and non-symmetrical polyalkynylbenzene are prepared by Pd-catalysed alkynylation of hexaiodobenzene or monoalkoxypentabromobenzene with phenylacetylenes substituted by 3,7-dimethyloctyl peripheral chains. The molecular structures are confirmed by spectroscopic and spectrometric analysis. The phenylacetylene bearing 3,7-dimethyloctyl peripheral aliphatic chains via oxygen (OR) or directly to the phenyl ring (R) functions to balance steric and space-filling effects of the peripheral branched chains. Symmetrical molecules in which the peripheral aliphatic chain directly attaches to the R and OR functional groups exhibit the columnar and the nematic/cholesteric phases, respectively. By introducing non-symmetry to the disc shape, the mesophase is stabilised above and below room temperature. This molecular tailoring significantly affects the intermolecular attraction forces and as a result affects the melting, clearing temperatures and the molecular packing.
Replacement ratio redux. (2002)

Disconnects between what employees need and expect to receive during retirement and what employer-sponsored plans provide can create workforce issues with important implications. By creating a model that analyzes the spend-down phase of retirement, the authors provide a framework for better understanding what employees will need to save during their working lifetimes.
Intramuscular Administration of Placenta-Derived Stromal Cells Enhances Survival of Rhesus Macaque Monkeys Exposed to Total Body Irradiation (2017)

Abstract Placenta-derived stromal cells named PLX-R18 have been shown in-vitro to secrete pro-hematopoiesis proteins, induce bone marrow migration, and promote colony formation. Murine in-vivo studies indicated that placental cells are capable of reducing lethality from the Hematopoietic Sub-syndrome of Acute Radiation Syndrome (HS-ARS). A NIAID-supported pilot study with non-human primate (NHP) rhesus macaque monkeys was conducted with the objective to characterize the effect of PLX-R18 on HS-ARS, including survival and hematological parameters in irradiated NHP. 62 male and female rhesus macaque monkeys were divided into irradiated and non-irradiated cohorts. Non-irradiated or irradiated NHPs were treated with three intramuscular doses of PLX-R18 at 1 and 5 days post irradiation, or with placebo control. All doses of PLX-R18 improved outcome of irradiated NHPs relative to placebo (dose of 4, 10 and 20M cells/kg increased survival by 33.3, 35.7 and 16.7% respectively). A tendency towards earlier recovery of blood lineages was evident in all doses tested, particularly, for the two lower doses. The 4 million cells/kg dose of PLX-R18 reduced the duration of critical neutropenia, thrombocytopenia, and anemia (NEUT Taken together, all doses of PLX-R18 positively affected survival rates and multiple hematological parameters of HS-ARS in rhesus monkeys and had no negative effects in either irradiated or non-irradiated monkeys. This supports the intended development of PLX-R18 as a treatment for HS-ARS. Disclosures Sher: Pluristem LTD: Employment, Equity Ownership. Prezma: Pluristem LTD: Employment, Equity Ownership. Fuchs-Telem: Pluristem LTD: Employment, Equity Ownership. Shraga- Heled: Pluristem LTD: Employment, Equity Ownership. Authier: CiToxLAB: Employment. Chang: SRI International: Employment. Ascah: CiToxLAB: Employment. Bakke: SRI International: Employment. Gahagen: SRI International: Employment. Ofir: Pluristem LTD: Employment, Equity Ownership.
Current Evidence on the Anticancer Potential of Chios Mastic Gum (2011)

Chios mastic gum derived from the plant Pistacia lentiscus L. variation chia has been shown to exert beneficial effects on a wide range of human disorders. The most comprehensive data so far have indicated that mastic gum provides protection against gastrointestinal malfunctions and bacterial infections. Substantial evidence has also suggested that mastic gum exhibits hepatoprotective and cardioprotective, antiinflammatory/antioxidant, and antiatherogenic properties. In the last decade, an increasing number of studies further evaluated the potential antiproliferative properties of mastic gum against several types of human neoplasia. The present review aims to summarize the current data concerning the anticancer activities of mastic gum and their major constituents, highlighting also the molecular mechanisms through which they exert anticancer function. Mastic gum constituents that belong to the chemical class of triterpenoids appear to be mainly responsible for its anticancer potential. Thus, a brief discussion is dedicated to the anticancer activity of synthetic and naturally occurring triterpenoid analogues with similar chemical structure to mastic gum constituents. Taking into consideration the available data so far, Chios mastic gum could be considered as a conglomeration of effective anticancer drugs.
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters (2012)

In mammals, many aspects of behavior and physiology such as sleep-wake cycles and liver metabolism are regulated by endogenous circadian clocks (reviewed). The circadian time-keeping system is a hierarchical multi-oscillator network, with the central clock located in the suprachiasmatic nucleus (SCN) synchronizing and coordinating extra-SCN and peripheral clocks elsewhere. Individual cells are the functional units for generation and maintenance of circadian rhythms, and these oscillators of different tissue types in the organism share a remarkably similar biochemical negative feedback mechanism. However, due to interactions at the neuronal network level in the SCN and through rhythmic, systemic cues at the organismal level, circadian rhythms at the organismal level are not necessarily cell-autonomous. Compared to traditional studies of locomotor activity in vivo and SCN explants ex vivo, cell-based in vitro assays allow for discovery of cell-autonomous circadian defects. Strategically, cell-based models are more experimentally tractable for phenotypic characterization and rapid discovery of basic clock mechanisms. Because circadian rhythms are dynamic, longitudinal measurements with high temporal resolution are needed to assess clock function. In recent years, real-time bioluminescence recording using firefly luciferase as a reporter has become a common technique for studying circadian rhythms in mammals, as it allows for examination of the persistence and dynamics of molecular rhythms. To monitor cell-autonomous circadian rhythms of gene expression, luciferase reporters can be introduced into cells via transient transfection or stable transduction. Here we describe a stable transduction protocol using lentivirus-mediated gene delivery. The lentiviral vector system is superior to traditional methods such as transient transfection and germline transmission because of its efficiency and versatility: it permits efficient delivery and stable integration into the host genome of both dividing and non-dividing cells. Once a reporter cell line is established, the dynamics of clock function can be examined through bioluminescence recording. We first describe the generation of P(Per2)-dLuc reporter lines, and then present data from this and other circadian reporters. In these assays, 3T3 mouse fibroblasts and U2OS human osteosarcoma cells are used as cellular models. We also discuss various ways of using these clock models in circadian studies. Methods described here can be applied to a great variety of cell types to study the cellular and molecular basis of circadian clocks, and may prove useful in tackling problems in other biological systems.
ChemInform Abstract: Synthesis of 3,5‐Disubstituted 1‐Amino‐1,3,5‐triazine‐2,4‐6‐triones (or 1‐Aminocyanurates) by Cyclic Transformation of 1,3,4‐Oxadiazol‐2(3H)‐one Derivatives. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
J-Lay and Steep S-Lay: Complementary Tools for Ultradeep Water (2007)

Abstract The pipelines are major components of the oil and gas production. With Ultra deep water development, the increasing of assisted recovery and zero-flare policy, pipelines specifications are much more elaborate: fatigue resistance due to cyclical operational loads and frequent shutdowns, thermal insulation for flow assurance purpose. They are often short and associated with many singularities, termination or inline structures. The design of pipelines must take into account walking and buckling, lay out in congested areas, sometimes with geohazards issues. The paper will expose the design of the different pipelines and associated components and describe how the contractors have met these challenges, improved the laying efficiency with using the J- lay method or the steep Slay, which is adapted from conventional laying method continuously improved since the seventies with a deep water application resulting from the revisited strain criteria on the laying ramp. The S-lay methods are much more appropriate from the pipeline fabrication point of view, and appear as a better option for the laying of relative long lines such as gas trunk line or long tie back. The J lay method appears as a natural configuration from the catenary point of view and is much more appropriate to the installation of in line structures. The paper will illustrate with practical applications that these two methods are not opposed but are complementary tools and have each their own domain of excellence in the production and recovery of the hydrocarbon resources. Introduction The driving phenomena for deep water pipelines have drastically evolved over the last ten years with the development of deep water fields. The key driver for the design of the field layout and the flowlines is undoubtedly the flow assurance of multiphase fluids. This has led to a significant increase of insulated flowlines, which has had a great impact on the overall behavior of pipelines on the sea bed. The use of wet insulation materials such as polypropylene and polyurethane has resulted in a general reduction in the submerged weight of production flowlines, this in combination with the very soft soil conditions found in deep water locations has led to the significant increase in pipeline movements induced by pressure and temperature of the internal fluids. These movements known as pipe walking and lateral buckling have been the subject of much discussion within the offshore pipeline industry in recent years /1/, /2/, /3/, /4/. The details of these phenomena are not discussed in this paper, however the influence they have on the installation methods used for deep water pipelines will be addressed. The field layout selected for a particular offshore development has a significant influence on the pipelines and in particularly the installation techniques. In deep water fields, which are dominated by subsea wells, the field layout tends to be very different from those selected for more conventional water depths.
Protein phosphorylation in permeabilized pancreatic islet cells (1985)

A system of digitonin-permeabilized islet cells was developed to characterize Ca2+- and calmodulin-dependent protein phosphorylation further and to determine whether activation of this membrane-bound process was sufficient for initiation of Ca2+-stimulated insulin secretion. The efficacy of digitonin in permeabilizing the plasma membrane was assessed by Trypan Blue exclusion, by extracellular leakage of lactate dehydrogenase, and by permeability to [gamma-32P]ATP. This treatment did not detectably alter the ultrastructure of the permeabilized cells. Digitonin was equally effective when presented to islet cells that had been previously dispersed or directly to intact isolated islets. The Ca2+- and calmodulin-dependent phosphorylation of endogenous membrane-bound substrates could be demonstrated in the permeabilized cells incubated with [gamma-32P]ATP. This activity displayed characteristics that were similar to those described for the protein kinase measured in subcellular fractions and was dependent on addition of exogenous calmodulin, indicating that calmodulin had been removed from the kinase by permeabilization of the cells. Ca2+-dependent insulin release by the digitonin-permeabilized islet was demonstrated, with half-maximal release occurring at 0.1 microM-free Ca2+ and maximal secretion at 0.2 microM-free Ca2+. Under these conditions, calmodulin did not further enhance insulin release, although a stimulatory effect of calmodulin was observed in the absence of free Ca2+. These studies indicate that the permeabilized-islet model will be useful in dissecting out the factors involved in Ca2+-activated insulin secretion.
The Biosynthesis of Monensin-A: Thymine, .BETA.-Aminoisobutyrate and Methacrylate Metabolism in Streptomyces cinnamonensis. (1995)

Feeding experiments with isotopically labelled samples of [13C,2H3-methyl]-thymine, (R,S)-[I-13C]- and (R,S-[13C-methyl]-beta-aminoisobutyrates into monensin-A demonstrate that these metabolites can all contribute to the methylmalonyl-CoA pool in Streptomyces cinnamonensis, and implicate DNA catabolism as a contributory metabolic source of propionate carbon atoms for secondary metabolic biosynthesis. Further, these labelled compounds were unexpectedly incorporated into the butyrate unit of monensin-A, an observation which can be rationalised if beta-aminoisobutyrate is converted to methacrylyl-CoA and then reduced to isobutyryl-CoA prior to conversion to butyryl-Coa by the action of isobutyryl-CoA mutase. Feeding experiments with [I-13C]- and [13C-methyl]-methacrylates and [3-13C]-isobutyrate suggest that these metabolites partition similarly between the butyrate and propionate units of monensin-A consistent with the view that isobutyryl-CoA and methacrylyl-CoA have a close metabolic relationship.
Microvascular Breast Reconstruction and Lymph Node Transfer for Postmastectomy Lymphedema Patients (2012)

Simultaneous breast and lymphatic reconstruction is an ideal option for patients who suffer from lymphedema after mastectomy and axillary dissection.
Analysis of withanolides in root and leaf of Withania somnifera by HPLC with photodiode array and evaporative light scattering detection (2007)

A reversed-phase HPLC method for the simultaneous analysis of nine structurally similar withanolides, namely, 27-hydroxy withanone, 17-hydroxy withaferin A, 17-hydroxy-27-deoxy withaferin A, withaferin A, withanolide D, 27-hydroxy withanolide B, withanolide A, withanone and 27-deoxywithaferin A, has been developed using a linear binary gradient solvent system comprising methanol and water containing 0.1% acetic acid. Both photodiode array and evaporative light scattering detection were used to profile the extract compositions and to quantify the withanolides therein. Homogeneity and purity of each peak was ascertained by comparative evaluation of the on-line UV spectra of the eluted compounds with those of the reference compounds. The method has been validated with respect to various parameters of performance quality including computation regression analysis based on calibration curves, peak resolution factor, asymmetry factor, tailing factor, RSD (%) of retention time and peak area response, limit of quantivation, limit of detection, precision and recovery. The developed method has been applied to the analysis of leaf and root tissues of Withania somnifera for withanolide content.
DNA On Silicon Devices: On-Chip Synthesis, Hybridization, and Charge Transfer (2002)

Complementary strands and redox intercalators can be self-assembled into nanoscale structures capable of charge transfer at the electrode surface from DNA oligomers synthesized directly at covalently modified semiconductor silicon surfaces (see schematic representation).
Homologs of Breast Cancer Genes in Plants (2011)

Since the initial discovery of genes involved in hereditary breast cancer in humans, a vast wealth of information has been published. Breast cancer proteins were shown to work as tumor suppressors primarily through their involvement in DNA-damage repair. Surprisingly, homologs of these genes can be found in plant genomes, as well. Here, we want to give an overview of the identification and characterization of the biological roles of these proteins, in plants. In addition to the conservation of their function in DNA repair, new plant-specific characteristics have been revealed. BRCA1 is required for the efficient repair of double strand breaks (DSB) by homologous recombination in somatic cells of the model plant Arabidopsis thaliana. Bioinformatic analysis indicates that, whereas most homologs of key components of the different mammalian BRCA1 complexes are present in plant genomes, homologs of most factors involved in the recruitment of BRCA1 to the DSB cannot be identified. Thus, it is not clear at the moment whether differences exist between plants and animals at this important step. The most conserved region of BRCA1 and BARD1 homologs in plants is a PHD domain which is absent in mammals and which, in AtBARD1, might be involved in the transcriptional regulation of plant development. The presence of a plant-specific domain prompted us to reevaluate the current model for the evolution of BRCA1 homologs and to suggest a new hypothesis, in which we postulate that plant BRCA1 and BARD1 have one common predecessor that gained a PHD domain before duplication. Furthermore, work in Arabidopsis demonstrates that - as in animals - BRCA2 homologs are important for meiotic DNA recombination. Surprisingly, recent research has revealed that AtBRCA2 also has an important role in systemic acquired resistance. In Arabidopsis, BRCA2 is involved in the transcriptional regulation of pathogenesis-related (PR) genes via its interaction with the strand exchange protein RAD51.