gebhart/patrepeval huggingface dataset:
Effect of Fentanyl Infusion on Heart Rate Variability and Anaesthetic Requirements in Isoflurane-Anaesthetized Horses (2021)

Controversy continues to surround the use of opioids in equine anaesthesia, with variable effects reported. This blinded clinical study aimed to investigate the influence of a low-dose fentanyl continuous rate infusion (CRI) on isoflurane requirements, parasympathetic tone activity (PTA), and anaesthetic parameters in horses during general anaesthesia. All of the twenty-two horses included in the research underwent a standard anaesthetic protocol. Eleven horses in the fentanyl group (Group F) received a loading dose of fentanyl at 6 µg/kg, followed by a CRI of 0.1 µg/kg/min during anaesthesia. A further 11 horses in the control group (Group C) received equivalent volumes of normal saline. Anaesthetic parameters and PTA index were recorded during anaesthesia. The achieved mean fentanyl plasma concentration was 6.2 ± 0.83 ng/mL. No statistically significant differences between groups were found in isoflurane requirements, MAP values, and mean dobutamine requirements. However, horses in Group F required a significantly lower dose of additional ketamine to maintain a sufficient depth of anaesthesia. Significantly higher PTA values were found in the fentanyl group. Further research is warranted to determine the limitations of PTA monitoring, and the influence of various anaesthetics on its values.
Using Animal Models in Osteoarthritis Biomarker Research (2011)

Osteoarthritis (OA) is a disease that commonly affects human and veterinary patients. Animal models are routinely used for OA research, and the dog is a nearly ideal species for translational investigation of human OA biomarkers. The cytokine, chemokine, and matrix metalloprotease (MMP) profiles of synovial fluid, serum, and urine from dogs with surgically induced and naturally occurring OA were compared with dogs without OA using xMAP technology (Qiagen Inc., Valencia, CA). Markers that exhibited significant differences between groups were identified (monocyte chemoattractant protein 1 [MCP1], interleukin 8 [IL8], keratinocyte-derived chemoattractant [KC], and MMP2 and MMP3), and their sensitivities and specificities were calculated to determine their diagnostic usefulness in a future biomarker panel. Synovial fluid IL8 was the most sensitive, but MCP1 was also highly sensitive and specific. The alterations in KC suggested that it may differentiate between cruciate disease and other types of OA, and the MMPs were most sensitive and specific in the serum. This study provided additional insight to the participation of cytokines, chemokines, and MMPs in OA, and potential diagnostic biomarker candidates were identified. A brief literature review of other biomarker candidates previously examined using animal models is discussed.
The Effects of Delay on the Input Function for Early Dynamics in Total Body Parametric Imaging (2019)

The recently developed total-body PET scanner enables high temporal resolution in dynamic imaging. Due to the much improved temporal resolution and large field of view, delay and the dispersion effects in the image-derived input function, which vary for different tissues and organs, may affect accuracy in parametric imaging. In this paper, the delay effect was studied using the early kinetics of an FDG scan, which may be approximated using a 1-tissue compartment model. Dynamic reconstructed frames were acquired using the total-body PET scanner with 1-second frames for the first 30 seconds and 2 seconds for the subsequent 60 seconds. The image-derived input function was acquired from the reconstructed dynamic sequence using volumes of interest in the ascending and descending aorta. Voxel-specific delay times for the plasma input function were also modeled within the 1-tissue compartment model. A total of 4 parametric images were generated. Image-based parametric image generation was achieved with a maximum likelihood estimation method. Parametric images with and without the modeling of delay time in the input function were compared. Additional image denoising techniques including Gaussian denoising and non-local-mean denoising were employed. Quantitative evaluation was achieved by the calculation of the Akaike Information Criterion (AIC). The voxel-specific parameters of the 1-tissue compartment together with the delay time were successfully reconstructed using the proposed method. The estimated delay time showed variations as large as 40 seconds. The non-local-mean filter was shown to be able to reduce the image noise of the generated parametric images. Various image artifacts were observed when no delay time model was included. We have shown that with the use of total-body PET and the increased sensitivity, it is possible to estimate parametric images using the very early stages of the FDG injection. The combined effects of delay and dispersion will be studied in the future.
Alibaba, la Bourse et les rêves d'expansion ds géants de l'internet et des mobiles chinois (2014)

info:eu-repo/semantics/published
Validation of an Aid for Selection of Instructional Media and Strategies (1992)

A job aid, for use by instructional developers, which facilitates the selection of instructional media and strategies (MS. AID) was evaluated. Results indicate that the aid can significantly increase the effectiveness and reliability of decisions.
P1‐038: Highly sensitive detection of amyloid beta for Alzheimer's disease diagnosis using bead‐based impedance spectrometry (2015)

Alzheimer's disease (AD) is the most common neurodegenerative disease of dementia, and the development of early diagnosis platform is highly required for effective therapeutics. Recently, amyloid beta (Aβ) has been considered as a major biomarker in AD diagnosis. Therefore, many researches have been studied in development of sensors to detect Aβ of low concentration by using electrical methods such as field effect transistor and electrochemical impedance spectroscopy (EIS) to overcome the relatively high limit of detection in ELISA. All these devices required immobilization with antibody on the surface of sensing region in device itself. They showed LOD of a few pg/ml. So, we propose a new highly sensitive detection platform to quantify the concentration of Aβ with immobilization of detection antibody not on the electrodes of EIS device but on the surface of magnetic beads. We designed a new detection platform including array of EIS device, fluidic channel and permanent magnet bar on/beneath a slide glass. EIS array device has individual hole on each working-counter electrode pair. The individual hole size is around 6 μm, and the bead size is around 2.8 μm. Therefore, each hole can capture 2 or 3 pre-treated beads that prepared by incubation with antibody. First pre-treated beads were injected into microfluidic channel, and these beads were located in each hole by the magnetic bar under a platform. Then, Aβ monomer with different concentration was flown into device for 5 min, then non-specific Aβ was removed by washing buffer. Finally, impedance measurement was measured with sweeping frequency. We were able to detect Aβ monomer below than 1 pg/ml with very small amount of sample (∼4 μl), and total detection time was dramatically reduced to less than 10 minutes. The results were clearly distinguishable among the Aβ samples with different concentration in impedance plot.
Marché du sexe en Suisse. Etat des connaissances, best practices et recommandations, Volet 3 – Mapping, contrôle et promotion de la santé dans le marché du sexe en Suisse (2009)

Les travailleuses et travailleurs du sexe constituent une population hétérogène, présentant des facteurs de vulnérabilité multiples face aux différents risques affectant le bien-être et l'état de santé. Cette complexité demande une connaissance approfondie du milieu afin de mettre en oeuvre les politiques publiques les mieux adaptées et les plus efficaces. Conscient de cet enjeu et du manque de données scientifiques sur le sujet en Suisse, l'Office Fédéral de la Santé Publique a mandaté en 2007 une équipe de sociologues de l'Université de Genève pour mener une vaste enquête en trois volets sur le marché du sexe en Suisse. Cette enquête avait comme objectif principal de fournir une base de connaissances pour le monde politique, associatif et pour les chercheuses et chercheurs concernés par le marché du sexe et les questions de santé s'y attenant. Le projet comporte trois volets. Le premier volet de l'étude offre un état des lieux de la littérature internationale et des projets dans le domaine de la santé des travailleuses du sexe. Les informations concernant les taux de prévalence du VIH-Sida et des autres infections sexuellement transmissibles, l'étiologie des troubles, les comportements face à la santé, ainsi que les projets et politiques de prévention y sont répertoriés. Le deuxième volet recense et analyse les bases légales fédérales, cantonales et dans une moindre mesure communales relatives au marché du sexe en Suisse. Le troisième volet de l'étude présente les résultats d'une enquête auprès de 200 acteurs (police, service des migrations, travail social, travail du sexe). Il dresse un panorama par canton du marché du sexe d'une part et des activités de prévention/promotion de la santé dans ce domaine d'autre part en vue d'identifier les succès des mesures en place et leurs principales barrières. L'ensemble des résultats (en français et allemand) a été rassemblé sur le site web interactif suivant : www.sexworkinfo.net. Cet ouvrage porte sur le premier volet de l'étude.
Railway Budget 2012-2013 (2012)

Budget 2012-2013
Intraoperative Electroencephalogram Suppression Predicts Postoperative Delirium (2015)

EEG suppression is an independent risk factor for postoperative delirium. Future studies should investigate whether anesthesia titration to minimize EEG suppression decreases the incidence of postoperative delirium. This is a substudy of the Systematic Assessment and Targeted Improvement of Services Following Yearlong Surgical Outcomes Surveys (SATISFY-SOS) surgical outcomes registry (NCT02032030).
Enhanced backscattering from a volume-scattering medium behind a phase screen (1995)

The enhanced-backscattering (EBS) phenomenon is investigated for the case in which a phase screen is placed close to a multiple-scattering medium. This situation results in a narrowing of the EBS peak that depends on the strength and the position of the phase screen. The resulting enhancement peak is essentially the sum of two contributions: the EBS produced by the multiple-scattering medium in the absence of the phase screen and the enhancement obtained when the multiple-scattering medium is replaced by a plane mirror.
Increased Use of Natural Gas in Blast Furnace Iron-Making (2016)

Steelmaking is a highly carbon intensive process. Most of the CO2 emissions in steelmaking are from the blast furnace. Coke has been the major reductant used in a blast furnace since 1750. The recent boom in the US energy outputs due to shale rock formations has motivated the need to look at natural gas as a partial replacement for coke in a blast furnace. During the course of this project, the impact of higher natural gas utilization has been studied in detail. Theoretical models suggesting the injection of natural gas as a viable method to replace coke partially have been used. These theoretical claims have then been tested experimentally and the results have been discussed. The experimental work described includes reduction of hematite to wüstite, followed by the study of interaction of natural gas with a bed of iron pellets replicating the wüstite reserve zone of a blast furnace. Furthermore, the reforming of methane over metallic iron pellets was investigated and these reactions were tested under blast furnace conditions. Mass and energy balance calculations, along with experimental results were used to support the proposed shaft injection of natural gas.
Analog floating-gate, on-chip auditory sensing system interfaces (2005)

This paper describes our current efforts toward creating cooperative analog-digital signal-processing systems for auditory sensor and signal-processing applications. We address resolution issues that affect the choice of signal-processing algorithms arriving from an analog sensor. We discuss current analog circuit approaches toward the front-end signal processing by reviewing major programmable analog building blocks and showing how they can be interconnected to create a complete system. We also discuss our current IC approaches using this technology for noise suppression, as well as our current analog signal-processing front-end system for speech recognition. Experimental data is presented from circuits fabricated using a 0.5 /spl mu/m nwell CMOS process available through MOSIS.
Improvement of Fatigue Strength of Stainless Steel by Using a Cavitating Jet with an Associated Water Jet in Water (2007)

Peening method using cavitation impacts have been developed. In this peening method, cavitation bubbles were generated by a cavitating jet. In order to increase peening intensity, a low speed water jet was injected around a cavitating jet, as the water jet swept away residual bubbles, which weaken the cavitation impact. In the present paper, improvement of fatigue strength of stainless steel by using a cavitating jet with an associated water jet was investigated compared with the results of conventional cavitating jet. It was concluded that the cavitating jet with an associated water jet can peen the stainless steel more effectively compared with the conventional cavitating jet.
54 Protein folding simulation using temperature based cascade MD (2015)

Protein folding is a multi micro second time scale event and involves many conformational transitions. Large conformational transitions important for biological functions are difficult to capture u...
Energy-conserving grid routing protocol in mobile ad hoc networks (2003)

The lifetime of a mobile ad hoc network (MANET) depends on the durability of the battery resource of the mobile hosts. Earlier research has proposed several routing protocols specifically on MANET, but most studies have not focused on the limitations of battery resource. We propose a new energy-aware routing protocol, which can increase the durability of the energy resource and, therefore, the lifetime of the mobile hosts and the MANET. The proposed protocol can conserve energy by shortening the idle period of the mobile hosts without increasing the probability of packet loss or reducing routing fidelity. Simulation results indicate that this new energy-conserving protocol can extend the lifetime of a MANET.
Simultaneous retroperitoneal, thoracic, and cervical resection of postchemotherapy residual masses in patients with metastatic nonseminomatous germ cell tumors of the testis. (1996)

Simultaneous resection of neck, chest, and abdominal residual masses after chemotherapy for germ cell tumors is both a feasible and safe alternative to staged excision in selected patients who require surgical intervention at multiple sites and fulfills the objective of rendering patients disease-free in a single operative procedure.
Examining the Effects of Scale, Mass Ratios and Column Shapes on the Vortex Induced Motion Response of a Semisubmersible Through CFD Analyses (2014)

The phenomenon of vortex induced motions (VIM) of a semisubmersible has been observed in the field and in model tests. The VIM response can be onerous to the fatigue live of SCR’s that are supported from the semisubmersible. Field observations indicate significantly smaller VIM amplitude than what present day model tests predict. The Scruton number is a parameter which affects the magnitude of the VIM response; the Scruton number includes the effect of mass ratio and damping. The effect of damping on VIM response has been examined in model test scale, and this analysis indicated that damping has a minimal effect on the VIM response amplitudes. The effect of the mass ratio and the effect of performing physical experiments at model scale are examined through CFD analyses. The objectives of the CFD analyses are to focus on the VIM phenomenon itself and to compare response magnitudes, while giving less importance to semisubmersible hull details and absolute response magnitudes. Hence, most of the CFD work is done in a 2D environment. Responses for various column cross-sectional shapes are examined; the column cross-sectional shapes include square, rectangular and five-sided. The VIM response is the result of pressures acting on the semisubmersible columns. The CFD analyses provide means to obtain the pressures at various locations at the various columns, and therefore can be used as a way to describe the phenomenon. These pressure data sets are evaluated to show where the majority of the excitation occurs and phase relationships between excitation forces acting on each individual column are presented.
Waterborne polar macromolecules act as algal antifoulants in the seaweed Ulva reticulata (2004)

Repetitive field observations in Hong Kong waters revealed that the green macroalga Ulva reticulata was conspicuously free of epibiotic macroorganisms. This phenomenon was indicative of some sort of natural antifouling control in a macroalga that has been typified as undefended thus far. In previous studies, we identified the alga itself and a thallus-associated epibiotic Vibrio sp. as sources of waterborne, macromolecular substances with an inhibitory effect on the larval attachment of the polychaete Hydroides elegans. Employing a less artifactual water collection technique under field conditions in this study, we demonstrated that naturally obtained algal exudates evoked a similar inhibitory effect as those obtained artificially under laboratory conditions. In order to interpret the chemical defense system of U. reticulata with respect to the production and nature of bioactive metabolites, the allelopathic activity of secondary metabolites obtained from Vibrio sp. and the macroalga was bioassayed and biochemically analyzed in parallel. In addition to H. elegans, bioassays were performed with larvae of the bryozoan Bugula neritina. Different enzyme probes revealed chemical and structural features of the factor inhibitory to larval attachment in both samples, and pointed to large polysaccharide units and sulfate esters as structural parts of the bioactive moiety. Specific susceptibilities of the algal and bacterial samples to proteolytic enzymes indicated that (a) different macromolecular constituents were causative of the inhibitory effect, and (b) that the bioactive moiety in the alga-derived sample comprised a structural connection between carbohydrate(s) and proteinaceous molecular domains. The results indicated an antifouling concept in U. reticulata that was presumably driven by at least 2 different waterborne macromolecules, and revealed that highly water soluble macromolecules may play an essential chemical ecological role in a marine system. This exemplifies a distinct concept in comparison to other prominent examples of algal antifoulants, which exclusively comprise comparatively small and non-polar algal metabolites.
ChemInform Abstract: CONVERSIONS OF THIOCHROMAN‐4‐ONES INTO 1,2‐BENZOTHIAZEPINE, BENZO(B)THIOPHENE, AND 1,2‐BENZISOTHIAZOLE SYSTEMS VIA SULFIMIDE INTERMEDIATES (1981)

Abstract Umsetzen der Thiochromanone (I) mit Chloramin Tliefert ein leicht trennbares Gemisch der N‐Tosylsul?mide (II) und der Sulfoxide (III).
The Synthesis of 5-Dimethylamino-4,4-diphenyl-2-pentanol (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of 5-Dimethylamino-4,4-diphenyl-2-pentanolNelson R. Easton and Velmer B. FishCite this: J. Am. Chem. Soc. 1955, 77, 7, 1776–1778Publication Date (Print):April 1, 1955Publication History Published online1 May 2002Published inissue 1 April 1955https://doi.org/10.1021/ja01612a017Request reuse permissionsArticle Views62Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (355 KB) Get e-Alertsclose Get e-Alerts
THE ULTRASTRUCTURAL LOCALIZATION OF CHOLINESTERASE ACTIVITY IN THE SCIATIC NERVE OF THE RAT (1966)

Ultrastructural localization of cholinesterase activity was demonstrated in rat sciatic nerve using thiocholine esters as substrate. This enzymatic activity was limited to axons, where it was located on limiting axonal membranes, and on axonal vesicles of all unmyelinated and some myelinated nerve fibers. No accentuation of activity was present at nodes of Ranvier. The use of acetyl, propionyl and butyrylthiocholine as substrate resulted in decreasing amounts of end product precipitate, respectively. The cholinesterase activity was sensitive to heat, resistant to N-ethyl maleimide, and inhibited byeserine, DFP, E600, RO2-1250 and BW 62C47. Studies of specific inhibition sensitivities and substrate preferences suggested that the axonal cholinesterase of rat sciatic nerve is a specific acetylcholinesterase which is relatively homogeneous.
A role-based access control for intranet security (1997)

Secure intranets are founded on the protection of logical resources accessible in corporate enterprises. The paper discusses I-RBAC, role-based access control for intranet security which offers efficient security management based on varied levels of role authorizations.
Overview of Polycyclic Aromatic Compounds (PAC) (2015)

The chemical group of polycyclic aromatic compounds (PAC), including the better-known subgroup of polycyclic aromatic hydrocarbons (PAH) and the heterocyclic aromatic compounds (NSO-PAC, heterocycles), comprise several thousand individual compounds. It is hard to find a comprehensive overview in the literature of these PACs that includes a substantial amount of relevant properties. Here an attempt is made to summarize the most studied but also some less well-known PACs. In addition to basic data such as recommended names, abbreviations, CAS numbers, molecular formulas, chemical structures, and exact mono-isotopic molecular weights, physico-chemical properties taken from the literature like boiling points, vapor pressures, water solubilities, Henry's Law constants, <i>n</i>-octanol-water partition coefficients (log K<sub>OW</sub>), and pK<sub>a</sub> are summarized. Selected toxicological data are listed indicating carcinogenic and mutagenic activity or effects on different organisms. PAC nomenclature is a complex topic, so suggestions for practical use are made. Regarding available data, estimated (instead of measured) values should be used with caution because considerable deviations from experimentally determined values can occur. For an enhanced understanding of the behavior of single PACs in comparison with each other, some of the properties mentioned above are plotted vs. the number of rings or the degree of alkylation. Also, some physico-chemical data are correlated with different functional groups as substituents of the PAHs. This article reveals that rather little is known about the less common PACs, e.g., higher molecular weight compounds, alkylated or otherwise substituted aromatics, for instance, keto-, oxo-, amino-, nitro-, cyano-PAHs, or some heterocyclic aromatic compounds, including their derivatives. It mirrors the limited state of knowledge about the variety of PACs that do not belong to the 16 EPA PAHs.