gebhart/patrepeval huggingface dataset:
Epidemiology of Bacterial, Fungal and Viral Infections in Children and Adolescents After Hematopoietic Stem Cell Transplantation (2012)

The epidemiology of bacterial, fungal and viral infections was retrospectively analyzed in a cohort of 759 children and adolescents who underwent allogeneic hematopoietic stem cell transplantation (HSCT) in a single institution, between 1990-2009, to study the impact of changes in transplantation methodology on the distribution of pathogens and mortality due to infections. There were 243 matched-related, 239 matched-unrelated (MUD) and 176 haplo-identical donor transplants. Independent logistic regression was conducted at 0-30 days (A), 30-100 days (B) and >100 days (C) post-transplant. On multivariate analysis, total body irradiation (p = 0.001, A; 0.005, C), apheresis product (p = 0.02, A; 0.01, B), acute (p = 0.002, B) and chronic (p = 0.03, C) graft vs host disease (GVHD) were associated with higher risk for bacterial infections at the respective time periods. CMV serostatus (p = 0.05, B), presence of acute (p = 0.001, B), chronic GVHD (p<0.001, C) and age >10 yrs (p = 0.02, C) were associated with higher risk for fungal infections. CMV serostatus (p = 0.0005, A; 0.03 B; 0.002 C), acute (p = 0.01, A) and chronic GVHD (p = 0.001, C), were associated with higher risk for viral infections. MUD donor transplants were associated with a higher risk of viral infections (p = 0.001). Bacterial (p = 0.002) and fungal (p = 0.0004) infections in period A, decreased in the 2005-2009 era. There were 321 episodes of bacteremia in 231(30%) patients, of whom 168 episodes (52%) were in period C. Staphylococcus epidermidis (33%) and Escherichia coli (12%) were the most common causes of bacteremia. Candidemia, mostly C.albicans, was detected in 49 (6%) patients, 26 (54%) in period C. There were 45 patients with proven aspergillosis, 20 (44%) in period A. Non-aspergillus molds were detected in 16 (2%) patients. CMV and adenoviremia was detected in 146 (20%) and 68 (9%) patients respectively. Parainfluenza was the most common respiratory viral infection detected in 70 (9%) patients, 35(50%) in period C. This is the largest retrospective study providing a time line of infections in children and adolescents who have undergone allogeneic HSCT.
A high-speed buck converter for efficiency enhancement of W-CDMA power amplifiers (2012)

We present a design strategy for a buck converter, which fulfills the high dynamic requirements of efficient envelope amplifier needed by modern efficiency enhancement techniques for power amplifiers . The proposed DC–DC converter has an innovative control system, which makes it fast, robust, and resource saving. A mathematical model describes its dynamic behavior and is used to find a setup, which gives an optimal compromise between the dynamic performance and efficiency. The approach is applicable to various state-of-the-art communication standards. As an example, an envelope following (EF) power amplifier (PA) for the wideband code-division-multiple-access (W-CDMA) modulation scheme is treated. The corresponding buck converter is implemented in a monolithic chip (except the inductor and the capacitor of the output filter). The measurements with an industry standard W-CDMA PA (RMPA2265) match very well with the forecast of the model and confirm doubling of the average efficiency.
Chemotactic factor influences on the aggregation, swelling, and foreign surface adhesiveness of human leukocytes. (1978)

Chemotactic factors have been shown to induce aggregation and cellular swelling of rabbit polymorphonuclear neutrophils (PMN) obtained from the peritoneum. We examined the ability of the chemotactic fragment of C5 and the synthetic chemotactic tripeptide formyl-methionyl-leucyl-phenylalanine to induce these changes in various preparations of human leukocytes. We found that these factors did induce dextran-sedimented leukocytes and Ficoll-Hypaque-isolated PMN to aggregate and swell. Compared with rabbit peritoneal PMN, however, human PMN responded with more prominent swelling but with less prominent aggregation. Also unlike rabbit peritoneal PMN, human PMN adhered spontaneously to plastic surfaces; the chemotactic factors enhanced this adherence. Certain similarities between the responses of these two cell types were evident: in both rabbit peritoneal and isolated human peripheral PMN, the aggregates had a short life span in the fluid phase; in both, the number of aggregates formed was proportional to the log10 of the PMN concentration; and, in both, the chemotactic activity of the reagents paralleled their aggregating activity. In the system employed, lymphocytes were unresponsive to the chemotactic factors. Ficoll-Hypaque-isolated mononoclear cells (containing varying proportions of monocytes and lymphocytes) were responsive, indicating that human monocytes behave in a manner similar to the human PMN. The results suggest that chemotactic factors induce responsive cells to develop a hyperadherent cytoplasmic membrane. Aggregation and increased adhesiveness to plastic surfaces may reflect this induction.
Age-Related Changes in the Anterior Segment Biometry During Accommodation (2015)

Age-related changes in the lens reshaping and ciliary muscle forward movement were found. Lens reshaping was much slower than the contraction of the ciliary muscle, especially in aging eyes, and this process required the ciliary muscle to contract more to reach a given response.
High-Speed Optical Modulators and Photonic Sideband Management. (2002)

We reviewed recent results in high-speed optical modulation. In addition to conventional modulators for digital intensity keying, we discussed novel modulation techniques for new function such as optical frequency shift, millimeter-wave generation, optical tunable delay, and so on.
Indenopyrazoles as Novel Cyclin Dependent Kinase (CDK) Inhibitors (2001)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTIndenopyrazoles as Novel Cyclin Dependent Kinase (CDK) InhibitorsDavid A. Nugiel, Ana-Marie Etzkorn, Anup Vidwans, Pamela A. Benfield, Michael Boisclair, Catherine R. Burton, Sarah Cox, Phillip M. Czerniak, Deborah Doleniak, and Steven P. SeitzView Author Information The DuPont Pharmaceuticals Company, Box 80336, Wilmington, Delaware 19880-0336 Cite this: J. Med. Chem. 2001, 44, 9, 1334–1336Publication Date (Web):April 19, 2001Publication History Received4 January 2001Published online19 April 2001Published inissue 1 April 2001https://pubs.acs.org/doi/10.1021/jm0100032https://doi.org/10.1021/jm0100032rapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views934Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Cells,Drug discovery,Inhibition,Peptides and proteins,Tumors Get e-Alerts
The Microwave Drill (2002)

We present a drilling method that is based on the phenomenon of local hot spot generation by near-field microwave radiation. The microwave drill is implemented by a coaxial near-field radiator fed by a conventional microwave source. The near-field radiator induces the microwave energy into a small volume in the drilled material under its surface, and a hot spot evolves in a rapid thermal-runaway process. The center electrode of the coaxial radiator itself is then inserted into the softened material to form the hole. The method is applicable for drilling a variety of nonconductive materials. It does not require fast rotating parts, and its operation makes no dust or noise.
The Teramac Custom Computer: Extending the Limits with Defect Tolerance (1996)

Teramac is a reconfigurable custom computer, capable of running million-gate user designs at one megahertz and out-performing workstations a hundred-fold on highly parallel applications. It achieves these results in spite of thousands of defects. Teramac, composed of 1728 field programmable gate arrays and over a quarter million interconnections, was made possible by a very broad use of defect tolerance. Given a user design and a defect database, a compiler creates a Teramac configuration that implements the design and makes no use of defective resources in the system. System characterization software precisely locates defective resources so that the vast majority of good resources may be applied to user designs. Defect tolerance reduces the cost of Teramac systems by increasing the yields of usable parts and by permitting the use of low-cost components that would otherwise be prohibitively unreliable.
Relationship between lake water chemistry and the surrounding landscape (1986)

A synoptic survey of the water chemistry of 175 Colorado lakes conducted in 1984 revealed that the lakes have distinctive chemical fingerprints reflecting the vegetation, geologic and land use characteristics of their watersheds. In 1985 they conducted vegetation and geologic surveys of 34 of these lakes. They also obtained water samples from 61 other lakes. The results of the water chemistry, vegetative mapping, soil and sediment analyses reveal that the lakes can be distinguished by four factors: bedrock, biological, lake morphology/soil development and trace elements; these factors describe the relationship between landscape ecological components and lake water chemistry. 5 references, 2 figures, 2 tables.
Intense laser-induced dissociation pathways of CD+ (2012)

The dissociation of CD+ induced by intense 30 fs pulses of central wavelengths 385 nm and 790 nm, over a range of peak intensities (5 × 1013 − 1 × 1016 W/cm2), was measured using a coincidence 3D momentum imaging technique. The observed kinetic energy release and angular distributions of the different products are presented and the possible dissociation pathways are discussed.
Cellularity and Cartilage Matrix Increased in Hypertrophied Ligamentum Flavum (2011)

Higher cellularity and increased cartilage matrix area are important changes in LF hypertrophy. These results suggest that BMP signaling and mechanical stress may play a role in the hypertrophied LF.
Evolution of Glycopeptide Resistance (2014)

This chapter briefly reviews the mode of action and the mechanism of bacterial resistance to glycopeptides, as exemplified by the VanB type, and discusses its diversity, regulation, evolution, origin, and recent dissemination to methicillin-resistant Staphylococcus aureus. Classification of glycopeptide resistance is based on the primary sequence of the structural genes for the resistance ligases. Although the six types of resistance involve related enzymic functions, they can be distinguished by the location of the corresponding genes and by the mode of regulation of gene expression. An interesting phenomenon that has developed in some VanB- and VanA-type enterococci is vancomycin dependence. These glycopeptide-dependent strains are also able to grow in the absence of glycopeptides if supplied with the dipeptide D-Ala-D-Ala, confirming that they are unable to produce the ligase encoded by the chromosomal ddl gene. The vanF operon is composed of five genes (vanYF, vanZF, vanHF, vanF, and vanXF) encoding homologues of VanY, VanZ, VanH, VanA, and VanX, and the genes essential for resistance (vanHF, vanF, and vanXF) are organized and oriented as in VanA-type strains. The evolutionary lineage of these groups of homologous genes is not clear, but they may have a common ancestor, or Paenibacillus could be a progenitor of the resistance operons acquired by enterococci. Conjugal transfer of plasmids that have acquired Tn1546-like elements by transposition appears to be responsible for the spread of glycopeptide resistance in enterococci.
An intelligent and autonomous endoscopic guidance system for minimally invasive surgery (2011)

The endoscopic guidance system for minimally invasive surgery presented here autonomously aligns the laparoscopic camera with the end-effectors of the surgeon's instruments. It collects information on the movements of the instruments from former interventions and can therefore predict them for autonomous guidance of the endoscopic camera. Knowledge is extracted by trajectory clustering, maximum likelihood classification and a Markov model to predict states. Alternative movements in an ongoing intervention are modeled. A first prototype of a robotic platform for minimally invasive surgery is described, which has two instrument arms, an autonomous robotic camera assistant and two haptic devices to control the instrument arms. The approach of long-term prediction and optimal camera positioning was tested in a phantom experiment with a hit rate of over 89% for predicting the movement of the end-effectors. Including this prediction for computing the camera position, leads to 29.2% less movements and to an improved visibility of the instruments.
Preface (2004)

A school psychologist in the United States who was seeking to assess the source of difficulties of a child with learning problems would be very likely to give the child a conventional intelligence test, such as the Stanford-Binet; a French psychologist would be unlikely to use such a test. The reason for the difference is that the two countries have different histories and current traditions with regard to the study and understanding of human intelligence. This particular pair of countries illustrates an especial irony because intelligence testing as we know it began at the turn of the twentieth century in France with a Frenchman, Alfred Binet, whereas widespread use of intelligence testing in the United States did not begin until World War I.
Resting‐State Brain Connectivity Predicts Weight Loss and Cognitive Control of Eating Behavior After Vertical Sleeve Gastrectomy (2019)

Our findings demonstrate changes in FC magnitude and directionality post versus pre surgery within and between resting-state networks and frontal, paralimbic, and visual areas in SG patients. Baseline FC predicted weight loss and changes in cognitive control of food intake behavior at 12 months. These could serve as predictive biomarkers for bariatric surgery.
On the Reactivity of Ferrocenoylsilanes (2002)

Reactions of ferrocenoylsilanes 1 with lithium aluminium hydride and organometallic reagents show unusual behaviour in that the ferrocenyl aldehydes 4 and ketones 5−9 are obtained instead of the expected secondary and tertiary silylated alcohols. This paper also reports on the synthesis and reactivity of the first planar chiral enantiomerically pure ferrocenoylsilane 1d that offers the possibility of synthesizing planar chiral enantiomerically pure 1,2-disubstituted aldehyde 4b and ketones 5b, 6b, 7b, 8 and 9. A mechanistic hypothesis is proposed for explaining the obtained results.
Kaposi's Sarcoma-Associated Herpesvirus K-bZIP Protein Is Necessary for Lytic Viral Gene Expression, DNA Replication, and Virion Production in Primary Effusion Lymphoma Cell Lines (2009)

Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of three human proliferative disorders, namely, Kaposi's sarcoma, primary effusion lymphomas (PEL), and multicentric Castleman's disease. Lytic DNA replication of KSHV, which is essential for viral propagation, requires the binding of at least two KSHV proteins, replication and transactivation activator (RTA) and K-bZIP, on the lytic origin of replication. Moreover, K-bZIP physically interacts with RTA and represses its transactivation activity on several viral promoters in transient transfection assays. To evaluate the physiological roles of K-bZIP in the context of PEL, we generated BCBL-1 cells with a tetracycline (Tet)-inducible small hairpin RNA (shRNA) directed against the K8 mRNA to knock down K-bZIP expression at different points during KSHV's life cycle. Using this model, we demonstrate that in the absence of K-bZIP expression, dramatic decreases in orf50, orf57, and orf26 transcript expression are observed. Similar effects were seen at the protein level for RTA (immediate-early protein) and K8.1 (late protein) expression. Interestingly, a direct correlation between K-bZIP levels and viral lytic mRNAs was noticed. As a consequence of K-bZIP knockdown, viral DNA replication and virion production were severely impaired. The same effects were observed following knockdown of K-bZIP in another PEL cell line, BC3. Finally, using shRNA-K8-inducible 293 cells, we report that de novo synthesis of K-bZIP is not necessary for initiation of infection and latency establishment. These data support the concept that K-bZIP is essential for lytic viral gene expression, viral DNA replication, and virus propagation in PEL cells.
Passive bodengebundene atmosphärische Fernerkundung von Temperatur-, Wasserdampf- und Wolkenwasserprofilen mit eine frequenzsynthetisierten Mikrowellen-Radiometer (1998)

An advanced microwave radiometer for profiling atmospheric parameters is described in this paper. The method accomplishing profiling is described. The innovations of the radiometer system, including utilization of a stable frequency synthesizer and the calibration system are described. The performance of several mathematical retrieval methods and representative profiles are presented, as well as several comparisons with radiosondes.
Ortho‐Carborane‐Functionalized Luminescent Polyethylene: Potential Chemodosimeter for the Sensing of Nucleophilic Anions (2011)

Ortho′s, Athos, and Aramis: The ortho-carborane-functionalized polyethylene, a new family of carborane-functionalized polymer, has been designed and synthesized by the copolymerization of ethylene with ω-ortho-carboranyl-α-olefin using a metallocene catalyst. A thin film of the copolymer displayed strong blue emission under UV irradiation whilst degradation of the carborane cage led to disappearance of the emission. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Deoxycholic acid impairs glycosylation and fucosylation processes in esophageal epithelial cells (2012)

It is generally accepted that esophageal adenocarcinoma arises from a Barrett's metaplastic lesion. Altered glycoprotein expression has been demonstrated in tissue from patients with Barrett's esophagus and esophageal cancer but the mechanisms regarding such changes are unknown. The bile acid deoxycholic acid (DCA) alters many cell signaling pathways and is implicated in esophageal cancer progression. We have demonstrated that DCA disrupts Golgi structure and affects protein secretion and glycosylation processes in cell lines derived from normal squamous epithelium (HET-1A) and Barrett's metaplastic epithelium (QH). Cell surface expression of glycans was identified using carbohydrate-specific probes (wheat germ agglutinate, conconavalin A, peanut agglutinin, lithocholic acid and Ulex europaeus agglutinin) that monitored N-glycosylation, O-glycosylation and core fucosylation in resting and DCA-treated cells. DCA altered intracellular localization and reduced cell surface expression of N-acetyl-D-glucosamine, α-methyl-mannopyranoside (Man/Glc) and fucose in both cell lines. Furthermore, DCA reduced the expression of epithelial growth factor receptor and E-cadherin in a manner analogous to treatment of cells with the N-glycan biosynthesis inhibitor tunicamycin. This is the first study to identify an altered Golgi structure and glycomic profile in response to DCA in esophageal epithelial cells, a process which could potentially contribute to metaplasia, dysplasia and cancer of the esophagus.
Supplemental Figures from Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8<sup>+</sup> T Cells (2023)

&lt;p&gt;This file contains the following figures: Supplemental Figure 1. The return of host lymphocytes is affected by the type of donor CD8+ T cells. Supplemental Figure 2. Return of myeloid cells after CTX leads to more rapid host cell reconstitution than TBI-containing regimens. Supplemental Figure 3. CTX and TBI differentially affect host T cells and NK cells. Supplemental Figure 4. Donor CD8+ T cells transferred into a TBI-conditioned host maintain functional efficacy. Supplemental Figure 5. ALT-803 (IL-15/IL-15Ra complexes) augment the persistence of Tc1 cells in irradiated hosts.&lt;/p&gt;
Embryology of the Abdominal Wall and Associated Malformations—A Review (2022)

In humans, the incidence of congenital defects of the intraembryonic celom and its associated structures has increased over recent decades. Surgical treatment of abdominal and diaphragmatic malformations resulting in congenital hernia requires deep knowledge of ventral body closure and the separation of the primary body cavities during embryogenesis. The correct development of both structures requires the coordinated and fine-tuned synergy of different anlagen, including a set of molecules governing those processes. They have mainly been investigated in a range of vertebrate species (e.g., mouse, birds, and fish), but studies of embryogenesis in humans are rather rare because samples are seldom available. Therefore, we have to deal with a large body of conflicting data concerning the formation of the abdominal wall and the etiology of diaphragmatic defects. This review summarizes the current state of knowledge and focuses on the histological and molecular events leading to the establishment of the abdominal and thoracic cavities in several vertebrate species. In chronological order, we start with the onset of gastrulation, continue with the establishment of the three-dimensional body shape, and end with the partition of body cavities. We also discuss well-known human etiologies.
Molecular Tailoring of Phenothiazine-Based Hole-Transporting Materials for High-Performing Perovskite Solar Cells (2017)

Phenothiazine-based compounds, PTZ1 and PTZ2, were synthesized through straightforward Buchwald–Hartwig and Suzuki–Miyaura cross-couplings, respectively, by binding the suitable donor groups (diarylamine or triarylamine) to a phenothiazine core. Phenothiazine-based structures were proven for the first time as hole-transporting materials in solution-processed lead trihalide perovskite-based solar cells. A dramatic effect exerted by the presence of phenylene spacers was observed on the relevant photovoltaic performances. The power conversion efficiencies measured under AM1.5 sun increase from 2.1% (PTZ1) to a remarkable 17.6% (PTZ2), a value rivaling those obtained with the state-of-the-art Spiro-OMeTAD (17.7%). These results indicate phenothiazine-based compounds as promising candidates to be used as readily available and cost-effective hole-transporting materials in perovskite solar cells.