gebhart/patrepeval huggingface dataset:
Restoration of the Expression of Transporters Associated with Antigen Processing in Lung Carcinoma Increases Tumor-Specific Immune Responses and Survival (2005)

A wide variety of human carcinomas have low expression of tumor-associated antigen presentation in the context of MHC class I antigens due to defects in the antigen presentation pathway. This immune evasion mechanism renders many tumors unrecognizable by host immune surveillance mechanisms. The present study examines the expression of HLA, tapasin, transporter associated with antigen processing 1 (TAP1), and beta2 microglobulin in human small cell lung carcinoma and non-small cell lung carcinoma. Immunohistochemical staining showed severe impairment of the antigen presentation pathway in all patients. In order to recover tumor immunogenicity, a nonreplicating adenovirus expressing human TAP1 (AdhTAP1) was used to restore the expression of TAP1 in the antigen presentation pathway-deficient mouse lung carcinoma cell line, CMT.64. Infection of CMT.64 cells with AdhTAP1 increased MHC class I antigen surface expression, antigen presentation, and susceptibility to antigen-specific CTLs. Fluorescence-activated cell sorting and ELISPOT analysis showed that AdhTAP1 treatment significantly increased dendritic cell cross-presentation and cross-priming of tumor antigens. Furthermore, ex vivo and in vivo AdhTAP1 treatment significantly retarded tumor growth and increased survival of mice bearing CMT.64 tumors. Fluorescence-activated cell sorting analysis and immunohistochemical staining showed a significant increase in CD8+ and CD4+ T cells and CD11c+ dendritic cells infiltrating the tumors. The results show that TAP should be considered as a part of the immunotherapies for various cancers because it is likely to provide a general method for increasing immune responses against tumors regardless of the antigenic composition of the tumor or the MHC haplotypes of the host.
Biotechnology in pulp and paper manufacture : applications and fundamental investigations : proceedings of the Fourth International Conference on Biotechnology in the Pulp and Paper Industry (1990)

Cell wall degradation and biopulping - energy saving in biomechanical pulping enzymatic and fungal treatment of pulps - optimization of kraft pulp bleaching by coriolus versicolor waste treatment - degradation of chlorinated phenols and gualocols by the white-pot fungus phanerochaete by-product bioconversions - fodder and yeast production in a Czechoslaviian pulp mill.
Balancing Lateral Loads Using Tendon-Based Supplemental Damping System (2000)

A new design and retrofit concept that deals with the placement and functional attributes of dampers for the seismic protection of buildings is presented. The configuration for the proposed concept is referred to as load balancing prestressed tendon-fuse + damper system. The system is based on the notion of prestressed load-balancing and uses a combination of tendons, fuse-bars, and dampers; the latter preferably possessing recentering and preload characteristics. It is shown that the system has a direct effect in reducing the overturning moment demand on the main structural elements. The new approach is first contrasted with the concept that is currently used by designers and advocated in FEMA 273. Next, an overall strategy is presented for the various phases of the design process. This includes the facets of conceptual and preliminary design as well as the final design verification process. The efficacy of the preliminary design phase is improved by a well-conceived single-degree-of-freedom idealization of the structural system. The general normalized design parameters for the supplemental system are then transformed for the multi-degree-of-freedom system based on specific configuration details. Finally, the seismic design and evaluation of a nine-story steel building is presented as an example of the applicability of the proposed design algorithm and system configuration.
Thione Complexes of Group Vib Pentacarbonyls (1975)

Abstract The photochemical preparation of Group VIB pentacarbonyls containing adamantanethione, thiobenzophenone, and ethylene trithiocarbonate ligands is detailed. Their physical properties and some attempted desulfurization reactions are described.
Lane Change Maneuvers for Automated Vehicles (2016)

By considering a lane change maneuver as primarily a longitudinal motion planning problem, this paper presents a lane change maneuver algorithm with a pragmatic approach to determine an inter-vehicle traffic gap and time instance to perform the maneuver. The proposed approach selects an appropriate inter-vehicle traffic gap and time instance to perform the lane change maneuver by simply estimating whether there might exist a longitudinal trajectory that allows the automated vehicle to safely perform the maneuver. The lane change maneuver algorithm then proceeds to solve two loosely coupled convex quadratic programs to obtain the longitudinal trajectory to position the automated vehicle in the selected inter-vehicle traffic gap at the desired time instance and the corresponding lateral trajectory. Simulation results demonstrate the capability of the proposed approach to select an appropriate inter-vehicle traffic gap and time instance to initialize the lateral motion of a lane change maneuver in various traffic scenarios. The real-time ability of the lane change maneuver algorithm to generate safe and smooth trajectories is shown by experimental results of a Volvo V60 performing automated lane change maneuvers on a test track.
Only one of the charged amino acids located in the transmembrane alpha-helices of the gamma-aminobutyric acid transporter (subtype A) is essential for its activity. (1993)

The gamma-aminobutyric acid (GABA) transporter (subtype A) is located in nerve terminals and catalyses coupled electrogenic uptake of the neurotransmitter with two or three sodium and one chloride ions. It contains 599 amino acids and 12 putative membrane spanning alpha-helices and is the first described member of a neurotransmitter transporter superfamily. The membrane domain contains 5 charged amino acids which are basically conserved. Using site-directed mutagenesis, we show that only one of them, arginine 69, is absolutely essential for activity. It is located in a highly conserved region encompassing parts of helices 1 and 2. The three other positively charged amino acids and the only negative charged one, glutamate 467, are not critical. These results suggest that the translocation pathway of the sodium ions through the membrane does not involve charged amino acid residues and underline the importance of the highly conserved stretch between amino acids 66 and 86.
CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma (2019)

Our data highlight the potential of CDK12 as a drug target for patients with HCC. The striking synergy of THZ531 and sorafenib suggests a potential combination therapy for this difficult to treat cancer.
Acute Mechanical Dilation of the Ureter: An Experimental Study (1987)

Forty-three kidney donor ureters were mechanically dilated in vitro with Van Buren sounds to an average of 21.2F. Thirty-three of these ureters, with an average pre-dilation diameter of 11.3F, could be dilated an additional average of 10.6F. The average dilated/nondilated diameter ratio in these ureters was 1.9. These experimental data suggest an undilated pelvic ureteral diameter and a manually dilated ureteral diameter of approximately the same size cited in the clinical literature.
14C‐MIB adsorption on PAC in natural water (1998)

A new way of measuring very low concentrations of MIB allows calculation of the PAC dose needed to mitigate odors caused by MIB. Kinetic and equilibrium studies using five powdered activated carbons (PACs) and 14 C‐labeled 2‐methylisoborneol (MIB) in Lake Michigan water produced guidelines for determining the dose of PAC needed to remove MIB. The equilibrium data, supported by predictions from the equivalent background compound competitive adsorption model, indicate that the percent MIB remaining at equilibrium is a function of the carbon dosage, independent of the initial MIB concentration. Kinetic experiments, analyzed in terms of the homogeneous surface diffusion model, demonstrated that the surface diffusion coefficient, D s , is independent of both carbon dosage and initial MIB concentration. Together these equilibrium and kinetic studies show that for any given PAC dosage in natural water and for any fixed time of contact, the percent MIB remaining in an ideal reactor is independent of the initial MIB concentration. Thus the PAC dosage required to mitigate any MIB episode for any contact time of interest may be quickly determined from a C t / C 0 × 100 percent versus C c plot. These studies have also exhibited a new application of 14 C‐MIB allowing for the rapid collection of reproducible and accurate adsorption data.
PERIPHERAL PLASMA PROGESTERONE CONCENTRATIONS IN SHEEP DURING THE OESTROUS CYCLE (1973)

SUMMARY Progesterone concentrations in peripheral plasma were measured once daily during one oestrous cycle in each of eight sheep. In addition, on days 4–5, 8–9, 12–13 and 15–16 of the oestrous cycle, blood samples were collected at 30-min intervals throughout each 24-h period. A total of three ewes was sampled in each 24-h period and the same three animals were not bled again for at least 1 week. Plasma progesterone concentrations in all the ewes fluctuated considerably throughout each 24-h period. The within-sheep within-day variations observed in peripheral progesterone concentrations were compared with the between-sheep within-day variations and the within-sheep between-day variations previously reported. It is concluded that these previously reported variations in peripheral plasma progesterone concentration could be attributed to within-day variations in each animal. On days 8–9 and 12–13 of the oestrous cycle there were significantly higher concentrations of progesterone in plasma during the hours of daylight than during the hours of darkness. In contrast, progesterone concentrations on days 4–5 and 15–16 were not found to be significantly different between the hours of daylight and darkness. These results suggest that diurnal changes in peripheral plasma progesterone concentration occur during the luteal phase of the ovine oestrous cycle.
Structural studies of the PARP-1 BRCT domain (2011)

The PARP-1 BRCT domain has the conserved BRCT fold that is known to be an important protein:protein interaction module in DNA repair and cell signalling pathways. Data indicating no significant protein:protein interactions between PARP-1 and XRCC1 likely results from the absence of poly(ADP-ribose) in one or both binding partners, and further implicates a poly(ADP-ribose)-dependent mechanism for localization of XRCC1 to sites of DNA damage.
Instance-Adaptive Video Compression: Improving Neural Codecs by Training\n on the Test Set (2021)

We introduce a video compression algorithm based on instance-adaptive\nlearning. On each video sequence to be transmitted, we finetune a pretrained\ncompression model. The optimal parameters are transmitted to the receiver along\nwith the latent code. By entropy-coding the parameter updates under a suitable\nmixture model prior, we ensure that the network parameters can be encoded\nefficiently. This instance-adaptive compression algorithm is agnostic about the\nchoice of base model and has the potential to improve any neural video codec.\nOn UVG, HEVC, and Xiph datasets, our codec improves the performance of a\nscale-space flow model by between 21% and 27% BD-rate savings, and that of a\nstate-of-the-art B-frame model by 17 to 20% BD-rate savings. We also\ndemonstrate that instance-adaptive finetuning improves the robustness to domain\nshift. Finally, our approach reduces the capacity requirements of compression\nmodels. We show that it enables a competitive performance even after reducing\nthe network size by 70%.\n
Possible Association Between Anti-Trisulfated-Heparin-Disaccharide (TS-HDS) Immunoglobulin M Autoantibody and Fibromyalgia Syndrome. (2023)

There is a possible association between FMS and anti-TS-HDS IgM. This association might be the missing link for the coexistence of SFN and FMS, but further study should be performed to assess this association and this auto-antibody characteristic.
Flagellar Glycosylation in Burkholderia pseudomallei and Burkholderia thailandensis (2011)

Glycosylation of proteins is known to impart novel physical properties and biological roles to proteins from both eukaryotes and prokaryotes. In this study, gel-based glycoproteomics were used to identify glycoproteins of the potential biothreat agent Burkholderia pseudomallei and the closely related but nonpathogenic B. thailandensis. Top-down and bottom-up mass spectrometry (MS) analyses identified that the flagellin proteins of both species were posttranslationally modified by novel glycans. Analysis of proteins from two strains of each species demonstrated that B. pseudomallei flagellin proteins were modified with a glycan with a mass of 291 Da, while B. thailandensis flagellin protein was modified with related glycans with a mass of 300 or 342 Da. Structural characterization of the B. thailandensis carbohydrate moiety suggests that it is an acetylated hexuronic acid. In addition, we have identified through mutagenesis a gene from the lipopolysaccharide (LPS) O-antigen biosynthetic cluster which is involved in flagellar glycosylation, and inactivation of this gene eliminates flagellar glycosylation and motility in B. pseudomallei. This is the first report to conclusively demonstrate the presence of a carbohydrate covalently linked to a protein in B. pseudomallei and B. thailandensis, and it suggests new avenues to explore in order to examine the marked differences in virulence between these two species.
High power fiber MOPA based QCW laser delivering pulses with arbitrary duration on demand at high modulation bandwidth (2015)

We report on a concept of a fiber MOPA based quasi-CW laser working at high modulation bandwidths up to 40 MHz capable of producing arbitrary pulse durations at arbitrary repetition rates. An output power of over 100 W was achieved and an on-off contrast of 25 dB. The laser features a dual-channel (dual-wavelength) seed source, a double stage YDF amplifier and a volume-Bragg-grating-based signal de-multiplexer. Minimization of transients was conducted through experiment and model analysis.
Coordinate Regulation of Glucocorticoid Receptor and c-jun Gene Expression Is Cell Type-Specific and Exhibits Differential Hormonal Sensitivity for Down- and Up-Regulation (1996)

We have previously proposed a novel mechanism for the coupled regulation of glucocorticoid receptor (GR) and c-jun transcription in triamcinolone acetonide (TA)-treated AtT-20 cells. This involved transcriptional interference of AP-1 (Fos/Jun)-driven gene transcription by the formation of inactive GR/Jun heterodimers. To further elucidate the molecular mechanism for GR autoregulation, the expression of GR and c-jun mRNA and protein levels were examined in both mouse L929 fibroblast cells and human CEM-C7 acute lymphoblastic leukemia cells. A rapid down-regulation of both GR and c-jun mRNA and protein levels occurs in TA-treated L929 cells. All-trans-retinoic acid (RA) treatment of Jun-deficient, mouse F9, teratocarcinoma cells causes the induction of c-jun expression. The increased expression of both c-jun mRNA and protein is accompanied by the induction of GR expression. These data further suggest that functional cJun is needed for the expression of the GR and c-jun genes in F9 cells. CEM-C7 cells undergo apoptosis after exposure to glucocorticoids. There is a parallel up-regulation of GR and c-jun mRNA levels in TA-treated CEM-C7 cells. This is accompanied by a concomitant increase in GR and cJun protein levels. Dose-response analyses reveal the expected coordinate regulation of both GR and c-jun mRNA and protein in L929 cells (decreasing) and in CEM-C7 cells (increasing). However, approximately 20-fold less TA is required for the inhibition of GR and c-jun expression as compared to that required for the stimulation of these two genes. These data demonstrate that the coordinate regulation of GR and c-jun gene expression is dose-dependent and cell type-specific. These results, along with previously reported data, suggest that GR complex formation with itself or with another transcription factor is important for the coordinate up- and down-regulation, respectively, of the GR and c-jun genes.
System level simulation for 5G cellular communication systems (2017)

In 5G cellular communication systems, a new type of simulation methodology may be required due to the emergence of new services and applications, new environments and requirements, new performance indicators, and increased need for accurate end-toend performance measurements of systems including wired and wireless sections. In this paper, we address the characteristics of 5G simulations compared with 4G simulations especially focusing on system level simulation. Considering the characteristics of 5G simulations, the requirements for 5G simulators can be derived. In order to fulfill the requirements, a system level simulator is currently being developed and some selected features of the simulator are presented.
Interactive Segmentation for Color Image based on Color Saliency (2013)

Efficient interactive foreground extraction from color images is of great practical importance in computer vision. In recent yaers, an approach, based on optimization using graph-cuts has been widely used. However, an interactive foreground extraction approach, which is intuitive and efficient for users, is required for practical applications. In this paper, we propose a novel interactive foreground extraction method based on color saliency. In our method, the user provides only some foreground pixels as the initial reference. To achieve extraction of multi target objects, likelihoods of the foreground and background are defined by a gaussian mixture model and a color saliency map based on the provided reference pixels. These likelihoods are added to the cost of the proposed graph. Finally, image segmentation is performed by optimizing the proposed graph using the graph-cut algorithm.
Perceptual decomposition of virtual haptic surfaces (1993)

The analysis and construction of virtual haptic surfaces are considered from a perceptual point of view rather than from the dynamics and controls approach of prior work. The authors developed a perceptual decomposition of surface contact sensation by examining three qualities associated with the different stages of interaction with a haptic wall simulation. These qualities are the crispness of initial contact, the hardness of surface rigidity, and the cleanness of final release from the virtual wall's surface. These qualities, plus an overall rating of wall quality, were employed consistently by seven subjects to evaluate a set of six simple haptic wall simulations. Three of the wall models consisted of single linear springs; the remainder, single viscous dampers. Highest rankings of subjective hardness were associated with the spring models; damper models received the highest crispness rankings. Subjects favored the simple spring models as having, overall, the more wall-like perceptual character.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Design and Evaluation of an Ergonomic Virtual Thumb Keyboard for Tablet Computers (2014)

In this paper the design and evaluation of a split on-screen-keyboard for tablet computers is described whose layout is derived from the thumbs range and movement pattern when holding a tablet computer with two hands. For evaluation a usability study was conducted comparing the new design with a conventional virtual thumb keyboard. The ergonomic variant has 10
Diode-pumped self-Q-switched single-frequency 946-nm Nd^3+,Cr^4+:YAG microchip laser (2001)

A stable low-threshold self-Q-switched diode-pumped 946-nm Nd(3+), Cr(4+):YAG microchip laser operating in single frequency and fundamental transverse mode is reported. The output characteristics of the microchip laser were investigated under cw and pulsed pumping. By combination of the infrared microchip and an external frequency doubler, 473-nm pulses with a conversion efficiency of 18% were achieved.
Cyclic AMP and Cyclic GMP Concentrations in Normal and Pulpitic Human Dental Pulps (1979)

Frank Harper writes to R. W. Lawton to thank him for his letter and to inform him that Theodore Roosevelt is happy to hear from an American who lives in India.
Chemical Genetics Reveal the Novel Transmembrane Protein BIL4, Which Mediates Plant Cell Elongation in Brassinosteroid Signaling (2009)

Steroid hormones are conserved between animals and plants as signaling molecules to control growth and development. Plant steroid hormones, brassinosteroids (BRs), appear to play an important role in plant cell elongation. BRs bind to leucine-rich repeat kinase BRASSINOSTEROID-INSENSITIVE 1 (BRI1) localized to the plasma membrane, activate transcription factors in collaboration with cytosolic kinases and phosphatases, and regulate BR-responsive gene expression, but the details regarding the BR signaling pathway from perception to nuclear events remain unknown. In this study we used chemical genetics to identify an evolutionarily conserved transmembrane protein, Brz-insensitive-long hypocotyls 4 (BIL4), and demonstrated its role as a critical component of plant cell elongation occurring upon BR signaling. A dominant mutation, bil4-1D, showed cell elongation in the presence of the BR-specific inhibitor Brz. Brz suppresses expression of the BIL4 gene in wild-type plants, and overexpression of BIL4 in bil4-1D suppresses the BR deficiency caused by Brz. Our results indicate that BIL4 mediates cell elongation on BR signaling.
Controllable growth of NiCo2O4 nanoarrays on carbon fiber cloth and its anodic performance for lithium-ion batteries (2015)

NiCo<sub>2</sub>O<sub>4</sub>/CFC anodes coated with different thicknesses of NiCo<sub>2</sub>O<sub>4</sub> were fabricated to investigate the role of the CFC substrate.
Help of Microcontroller on Voltage Control to Reduce Transformer Inrush Current (2014)

At the moment of transformer energization by the supply voltage, a high current called transient inrush current, which may rise to ten times the transformer full load current, could be drawn by the primary winding. This paper discusses a microcontroller circuit with the intention of controlling and limiting the inrush current for a transformer, by the method of ramping up the supply voltage feeding to the transformer primary. Simulations and the experimental results show a significant reduction of inrush current, when the ramping up voltage is applied to the three-phase transformer load. The inrush current could be almost eliminated if the correct switching step rate is chosen.