gebhart/patrepeval huggingface dataset:
Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD (2013)

Epigenetic alterations offer promise as diagnostic or prognostic markers, but it is not known whether these measures associate with, or predict, clinical state. These questions were addressed in a pilot study with combat veterans with PTSD to determine whether cytosine methylation in promoter regions of the glucocorticoid related NR3C1 and FKBP51 genes would predict or associate with treatment outcome. Veterans with PTSD received prolonged exposure (PE) psychotherapy, yielding responders (n = 8), defined by no longer meeting diagnostic criteria for PTSD, and non-responders (n = 8). Blood samples were obtained at pre-treatment, after 12 weeks of psychotherapy (post-treatment), and after a 3-month follow-up. Methylation was examined in DNA extracted from lymphocytes. Measures reflecting glucocorticoid receptor (GR) activity were also obtained (i.e., plasma and 24 h-urinary cortisol, plasma ACTH, lymphocyte lysozyme IC50-DEX, and plasma neuropeptide-Y). Methylation of the GR gene (NR3C1) exon 1F promoter assessed at pre-treatment predicted treatment outcome, but was not significantly altered in responders or non-responders at post-treatment or follow-up. In contrast, methylation of the FKBP5 gene (FKBP51) exon 1 promoter region did not predict treatment response, but decreased in association with recovery. In a subset, a corresponding group difference in FKBP5 gene expression was observed, with responders showing higher gene expression at post-treatment than non-responders. Endocrine markers were also associated with the epigenetic markers. These preliminary observations require replication and validation. However, the results support research indicating that some glucocorticoid related genes are subject to environmental regulation throughout life. Moreover, psychotherapy constitutes a form of "environmental regulation" that may alter epigenetic state. Finally, the results further suggest that different genes may be associated with prognosis and symptom state, respectively.
Effects of aerosols and relative humidity on cumulus clouds (2007)

The influences of the aerosol type and concentration and relative humidity (RH) on cumulus clouds have been investigated using a two‐dimensional spectral‐bin cloud model. Three simulations are conducted to represent the polluted continental, clean continental, and marine aerosol types. Under the same initial dynamic and thermodynamic conditions, the maritime aerosol case results in more intensive radar reflectivity in both developing and mature stages than the continental aerosol cases, because of enhanced warm rain by collisions and ice processes by deposition growth due to larger droplet sizes and higher supersaturation, respectively. The considerable delay in convective development due to reduced droplet condensation is responsible for the longer cloud lifetime in the marine aerosol case. For the continental case, the most noticeable effects of increasing aerosol number concentrations (with 15 different initial values) are the increases of the cloud droplet number concentration and cloud water content but a decrease in the effective droplet radius. More latent heat release from increasing condensation results in stronger convection and more melting precipitation at the higher aerosol concentrations. Melting precipitation and secondary clouds primarily contribute to enhanced precipitation with increasing aerosols. The precipitation, however, decreases with increasing aerosol in the extremely high aerosol cases (over 5 × 10 4 cm −3 ) due to suppression of convection from depleted water vapor and inefficient coalescence. When the initial aerosol concentration exceeds a critical level, most of the cloud properties become less sensitive to aerosols, implying that the aerosol effect on deep convection is more pronounced in relatively clean air than in heavily polluted air. The aerosol effect on the cloud properties is strongly dependent on RH. As the surface RH increases from 40 to 70%, the cloud changes from shallow warm to deep convective types due to a significant increase of convective available potential energy (CAPE). The aerosol effects on the cloud microphysical properties and precipitation are negligible in dry air (40% surface RH), but much more significant in humid air (60‐70% surface RH). The rain delay is sensitive to RH, but not to aerosols under similar initial thermodynamic conditions.
Oxidative biodegradation mechanisms of biaxially strained poly(etherurethane urea) elastomers (1995)

As part of ongoing studies in polyurethane biostability and biodegradation, we have investigated an in vitro system to test strained poly(etherurethane urea) (PEUU). Recently, we utilized this system to reproduce in vivo stress cracking in strained Pellethane. In this study, strained PEUU was tested to determine whether it degrades through a common mechanism with Pellethane and to further examine the steps involved in this degradation. Biaxially strained PEUU elastomers were treated with an alpha 2-macroglobulin (alpha 2-Mac) protein solution followed by an oxidative H2O2/CoCl2 treatment. Characterization of the strained PEUU specimens was performed with attenuated total reflectance-Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), electron spectroscopy for chemical analysis, and contact angle analysis. The results from these characterization techniques provide conclusive evidence that biodegradation of PEUU and Pellethane occurs through a common mechanism. Chemical changes to the PEUU include cleavage of the polyether soft segments and urethane linkages, leaving the hard segment domains unaffected. SEM analysis shows that this chain cleavage leads to the development of severe pitting and cracking of the PEUU surface. In addition, the in vitro degradation accurately reproduces the in vivo degradation chemically and physically. This result verifies that the primary species responsible for biodegradation of PEUUs, in vivo, are hydroxyl and/or hydroperoxide radicals. alpha 2-Mac pretreatment increases the rate of degradation compared to direct treatment in H2O2/CoCl2. As the PEUU soft segment chains are cleaved, the degradation products are extracted into the treatment solution or environment. Finally, a new biodegradation mechanism of PEUUs is presented that involves crosslinking of the polyether soft segments.
Gas-Phase Chemistry of the Silaformamide Ion (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas-Phase Chemistry of the Silaformamide IonJoseph A. Hankin, Michele Krempp, and Robert DamrauerCite this: Organometallics 1995, 14, 6, 2652–2663Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/om00006a011https://doi.org/10.1021/om00006a011research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A hybrid speech recognition system using HMMs with an LVQ-trained codebook (2002)

A speech recognition system using the neurally inspired learning vector quantization (LVQ) to train hidden Markov model (HMM) codebooks is described. Both LVQ and HMMs are stochastic algorithms holding considerable promise for speech recognition. In particular, LVQ is a vector quantizer with very powerful classification ability. HMMs, on the other hand, have the advantage that phone models can easily be concatenated to produce long utterance models, such as word or sentence models. The algorithm described combines the advantages inherent in each of these two algorithms. As the result of phoneme recognition experiments using a large vocabulary database of 5240 common Japanese words uttered in isolation by a male speaker, it is confirmed that the high discriminant ability of LVQ could be integrated into an HMM architecture easily extendible to longer utterance models.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
In vitro response of T cells from aplastic anemia patients to antilymphocyte globulin and phytohemagglutinin: colony-stimulating activity and lymphokine production. (1991)

The aim of the present study was to compare the response of bone marrow (BM) lymphocytes from patients with aplastic anemia (AA) or normal controls to increasing doses of antilymphocyte globulin (ALG) or phytohemagglutinin (PHA). For this purpose BM T-enriched cells from 11 AA patients and 9 normal individuals were incubated with ALG (0-1000 micrograms/ml) or PHA (0%-10%) for 1 day, and the supernatants were tested for suppression/enhancement of granulocyte-macrophage colony-forming unit (CFU-GM) growth and for release of granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) assayed with the enzyme-amplified sensitivity immunoassay (EASI). The production of colony-stimulating activity (CSA) by T cells primed with ALG and tested in the absence of exogenous GM-CSF correlated with the dose of ALG in priming cultures up to 14% EG (100% EG = CFU-GM growth with 30 ng/ml of GM-CSF). The amount of GM-CSF in the supernatants paralleled their capacity to sustain CFU-GM growth (up to 3.5 ng/ml of GM-CSF). Production of CSA or GM-CSF from T cells primed with PHA was significantly lower. Supernatants of PHA-primed T cells, when added to normal BM cells in the presence of exogenous GM-CSF, produced a dose-dependent inhibition of CFU-GM growth (down to 13% +/- 10% EG). The same supernatants contained detectable amounts of IFN-gamma and TNF-alpha (21 +/- 6.7 IU/ml and 4.6 +/- 2.9 ng/ml, respectively). IFN-gamma production from severe AA (SAA) T cells in response to PHA was significantly superior to the IFN-gamma production from normal T cells (21 +/- 6.7 IU/ml vs 9.5 +/- 7.1 IU/ml, p = 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)
Near‐field optical microscopy of localized excitations on rough surfaces: influence of a probe (1999)

Starting from the general principles of near-field optical microscopy. I consider the influence of a probe when being used to image localized dipolar excitations and suggest a way of evaluating the perturbation thus introduced. Using the rigorous microscopic (electric) point-dipole description, I calculate the self-consistent field intensity at the site of a probe dipole scanning over resonantly interacting object dipoles and show that the intensity distribution deviates from that existing in the absence of a probe. I demonstrate that this difference increases with an increase in the polarizability of the probe dipole. resulting eventually in a completely different intensity distribution. The calculations also show that the perturbation of the intensity distribution due to the presence of a probe decreases with an increase in the probe-sample distance. In order to evaluate the degree of perturbation. I suggest comparing the images obtained at different probe-sample distances. Finally, I formulate a simple rule of thumb that allows one to roughly estimate the probe-sample coupling when imaging localized excitations.
Functional Properties of a New Voltage-dependent Calcium Channel α2δ Auxiliary Subunit Gene (CACNA2D2) (2000)

We have positionally cloned and characterized a new calcium channel auxiliary subunit, alpha(2)delta-2 (CACNA2D2), which shares 56% amino acid identity with the known alpha(2)delta-1 subunit. The gene maps to the critical human tumor suppressor gene region in chromosome 3p21.3, showing very frequent allele loss and occasional homozygous deletions in lung, breast, and other cancers. The tissue distribution of alpha(2)delta-2 expression is different from alpha(2)delta-1, and alpha(2)delta-2 mRNA is most abundantly expressed in lung and testis and well expressed in brain, heart, and pancreas. In contrast, alpha(2)delta-1 is expressed predominantly in brain, heart, and skeletal muscle. When co-expressed (via cRNA injections) with alpha(1B) and beta(3) subunits in Xenopus oocytes, alpha(2)delta-2 increased peak size of the N-type Ca(2+) currents 9-fold, and when co-expressed with alpha(1C) or alpha(1G) subunits in Xenopus oocytes increased peak size of L-type channels 2-fold and T-type channels 1.8-fold, respectively. Anti-peptide antibodies detect the expression of a 129-kDa alpha(2)delta-2 polypeptide in some but not all lung tumor cells. We conclude that the alpha(2)delta-2 gene encodes a functional auxiliary subunit of voltage-gated Ca(2+) channels. Because of its chromosomal location and expression patterns, CACNA2D2 needs to be explored as a potential tumor suppressor gene linking Ca(2+) signaling and lung, breast, and other cancer pathogenesis. The homologous location on mouse chromosome 9 is also the site of the mouse neurologic mutant ducky (du), and thus, CACNA2D2 is also a candidate gene for this inherited idiopathic generalized epilepsy syndrome.
Strategy for room temperature spectroscopy of single molecules (1997)

Laser-induced fluorescence (LIF) from single molecules at room temperature displays rich dynamics of reversible and irreversible transitions within the photodestruction lifetime of the molecule. In contrast to ensemble studies, these transitions are directly resolved when the fluorescence signal is monitored in time. We present a strategy and describe the instrumentation needed for spectroscopic studies on a large number of individual molecules. It is based on a computer controlled optical system which automatically and rapidly positions single molecules in the excitation volume of a confocal microscope and subsequently performs spectroscopic measurements. Examples for such spectroscopies are presented.
Studies on Gelatin Crosslinked with Substituted Triazine (1992)

The swelling of differently crosslinked gelatin layers, which were hardened with substituted triazines has been studied. Thereby a direct influence of the molecular mass distribution of gelatin could not be found, but an effect of the different numbers of N-terminal groups could be detected, using a low-molecular mass and a high-molecular mass fraction of the same gelatin. If the number of N-terminal groups was diminished by about 25%, by alkylation with a sulphobetaine, the differences in swelling disappeared. Furthermore, the alkylation reduces the brittleness of the gelatin layer and the interaction of the gelatin with hydtvphilic colour couplers (so-called coupler viscosity).
Preparation of a crystalline linear high copolymer by topochemical photopolymerization of diolefin mixed crystals (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of a crystalline linear high copolymer by topochemical photopolymerization of diolefin mixed crystalsYasunari Maekawa, Peng Jin Lim, Kazuhiko Saigo, and Masaki HasegawaCite this: Macromolecules 1991, 24, 21, 5752–5755Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/ma00021a003https://doi.org/10.1021/ma00021a003research-articleACS PublicationsRequest reuse permissionsArticle Views72Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Linewidth enhancement factor for InGaAs/InP strained quantum well lasers (1990)

The linewidth enhancement factor α in an InGaAs/InP strained-layer multiple quantum well (MQW) laser emitting near 1.55 μm has been determined from the spontaneous emission spectra below threshold. The active layers in the MQW structure in this device are under 0.7% compressive strain. The measured α at the lasing wavelength is 2.0. The calculation of α using interpolated bandstructure parameters shows that it varies rapidly with injected carrier density and the calculated value for our device is close to the measured value. The small α for strained MQW InGaAs lasers should result in performance improvement that are advantageous for lightwave system application.
Novel Integration Techniques for Gap Waveguides and MMICs Suitable for Multilayer Waveguide Applications (2022)

This article discusses three integration and packaging techniques for gap waveguides and monolithic microwave integrated circuits (MMICs) suitable for multilayer waveguide applications. Two vertical transitions between microstrips and ridge gap waveguides (RGWs) are presented. The first vertical transition connects RGW to a microstrip line from the top where a rectangular patch has been used. Measured results of the transition in a back-to-back structure show that the reflection coefficient is better than −10 dB from 75 to 83 GHz, and the insertion loss for a single transition over the frequency band is 0.65–0.85 dB. The second vertical transition connects RGW to a microstrip line from the back by a slot in the ground plane. Measured results of the transition in a back-to-back structure show that the reflection coefficient is better than −10 dB from 69 to 86 GHz, and the insertion loss for a single transition is 0.65–1 dB over the frequency band. Commercially available E-band MMIC amplifiers are integrated with RGWs using the two proposed transitions. Moreover, for the very first time, the integration of MMIC with inverted microstrip gap waveguide (IMGW) is realized by a compact packaging structure that utilizes bond wires and capacitive pads. All the three active integrations are consistent with the passive measurements in terms of operational bandwidth, losses, amplifier gain flatness, and unwanted resonance suppression.
Almost Perfect Nonlinear Power Functions in Odd Characteristic (2011)

In this paper, two new families of functions in odd characteristic are constructed, and they are proved to be almost perfect nonlinear (APN) functions. Some of the “open cases” which were introduced by Helleseth are answered by these new APN functions.
Multivariate data analysis for Raman spectroscopic imaging (2009)

Abstract This article reviews the analytic techniques for Raman spectroscopic imaging with emphasis on chemometrics. Key information included in Raman spectra is often distributed broadly throughout the dataset. It is possible to condense the information into a very compact matrix representation by a chemometric technique of factor analysis such as principal component analysis (PCA) or self‐modeling curve resolution (SMCR). PCA yields two matrices called scores and loadings which complementarily represent the entire features broadly distributed in the dataset. This concept can be further extended to other forms of data transformation schemes, including bilinear data decomposition based on SMCR analysis. SMCR offers a firmer model which is chemically or physically interpretable. The information derived from these techniques readily brings useful insight into building a mechanistic model for understanding complex phenomena studied by Raman spectroscopy. Illustrative examples are given for applications of both PCA and SMCR to Raman imaging of pharmaceutical tablets. Copyright © 2009 John Wiley &amp; Sons, Ltd.
Improve the Charge Balance of White Phosphorescent Organic Light Emitting Diodes Using Co-Doped Electron Transport Layer in Emitting Layer (2011)

White phosphorescent organic light-emitting diodes (WPHOLED) with high efficiency and low driving voltage were achieved by incorporating an electron transport material (3TPYMB) into a hole transport-type host (TCTA) as a mixed-host structure. For electrons, the emitting layer is nearly barrier-free until they reach the region of exciton formation, which keeps the driving voltage low. Therefore, improved the charge carrier balance within the emitting layer and enhanced the power efficiency of device. White PHOLED at a luminance of 1000 cd/m 2 shown a driving voltage of 4.38 V, luminance efficiency of 36.1 cd/A, and power efficiency of 26.4 lm/W was observed. Furthermore, the power efficiency can be improved to 34.27 lm/W, and luminance efficiency to 46.7 cd/A by attaching a brightness enhancement film (BEF).
Protection of waterborne pathogens by higher organisms in drinking water: a review (2008)

Higher organisms are ubiquitous in surface waters, and some species can proliferate in granular filters of water treatment plants and colonize distribution systems. Meanwhile, some waterborne pathogens are known to maintain viability inside amoebae or nematodes. The well-documented case of Legionella replication within amoebae is only one example of a bacterial pathogen that can be amplified inside the vacuoles of protozoa and then benefit from the protection of a resistant structure that favours its transport and persistence through water systems. Yet the role of most zooplankton organisms (rotifers, copepods, cladocerans) in pathogen transmission through drinking water remains poorly understood, since their capacity to digest waterborne pathogens has not been well characterized to date. This review aims at (i) evaluating the scientific observations of diverse associations between superior organisms and pathogenic microorganisms in a drinking water perspective and (ii) identifying the missing data that impede the establishment of cause-and-effect relationships that would permit a better appreciation of the sanitary risk arising from such associations. Additional studies are needed to (i) document the occurrence of invertebrate-associated pathogens in relevant field conditions, such as distribution systems; (ii) assess the fate of microorganisms ingested by higher organisms in terms of viability and (or) infectivity; and (iii) study the impact of internalization by zooplankton on pathogen resistance to water disinfection processes, including advanced treatments such as UV disinfection.