gebhart/patrepeval huggingface dataset:
Study on the effects and its mechanism of 9.1C3 on CD2 or CD3 mediated cytotoxicities (2002)

Aim To explore the effects and its mechanism of 9.1C3 on CD2 or CD3 mediated cytotoxicities of activated PBMC. Methods The effects of 9.1C3 on CD2 or CD3 induced cytotoxicities were investigated by using redirected cytotoxicity assay, in which activated PBMC were used as effectors, and Fc receptor expressing P815 were used as target cells. The effects of 9.1C3 on CD2 or CD3 mediated [Ca2+]i increase in Jurkat cells were detected by spectrofluorometer. Results CD2 mediated cytotoxicity was inhibited significantly by 9.1C3 mAb, whereas CD3 mediated cytotoxicity was inhibited by 9.1C3 mAb to less extent. CD2 mediates [Ca2+]i increase in crosslinking dependent manner, and [Ca2+]i increase was inhibited in the presence of 9.1C3 mAb. However, CD3 mediates [Ca2+]i increase in crosslinking independent manner, and the increase was only inhibited in the presence of 9.1C3 mAb and crosslinker. Conclusion 9.1C3 can inhibit CD2 or CD3 molecule mediated cytotoxicities to different extent. The inhibition of CD2 mediated [Ca2+]i increase may be one mechanism of inhibitory effect of 9.1C3 on CD2 molecule mediated cytotoxicity. The lower inhibitory effect of 9.1C3 on CD3 molecule mediated cytotoxicity may be due to the absence of crosslinker in the experiment of incubating effect cells with antibodies in RCA.
Erasure coding for road-to-vehicle visible light communication systems (2011)

In this paper, we focus on a road-to-vehicle visible light communication (VLC) system using LED traffic lights. In this system, an LED traffic light consists of a 2-dimensional LED array (2D LED array), and cars are equipped with high-speed 2-dimensional cameras (2D image sensors). An important issue of this system is frame loss. Sometimes, 2D image sensor in a car fails to get a frame. So as to mitigate the influence of frame loss, we propose to apply erasure coding to the road-to-vehicle VLC system. In the proposed system, a data sequence is encoded by LDPC code whose length is much longer than the size of 2D LED array. In addition, code synchronization is required for the proposed system. We also propose a code synchronization scheme, which makes use of error detection capability of LDPC code. We evaluate the performance of our proposed system, and show that it can recover frame loss for high SNR when less than 8 frames among total 18 frames are lost. In addition, we show that our proposed code synchronization scheme can ignore its errors.
Low‐cost, high‐throughput and rapid‐prototyped 3D‐integrated dielectrophoretic channels for continuous cell enrichment and separation (2022)

Microfluidic devices for dielectrophoretic cell separation are typically designed and constructed using microfabrication methods in a clean room, requiring time and expense. In this paper, we describe a novel alternative approach to microfluidic device manufacture, using chips cut from conductor-insulator laminates using a cutter plotter. This allows the manufacture of microchannel devices with micron-scale electrodes along every wall. Fabrication uses a conventional desktop cutter plotter, and requires no chemicals, masks or clean-room access; functional fluidic devices can be designed and constructed within a couple of hours at negligible cost. As an example, we demonstrate the construction of a continuous dielectrophoretic cell separator capable of enriching yeast cells to 80% purity at 10 000 cells/s.
Abstract 1961: Downregulation of proteasome activity promotes epithelial-mesenchymal transition (2017)

Abstract The epithelial-mesenchymal transition (EMT) is a developmental program that is aberrantly activated in cancer cells, producing an invasive phenotype that can lead to metastases. Inducers of EMT are largely known and have been widely studied. However, the mechanisms that regulate the link between extracellular stimuli and EMT phenotypes remain poorly understood. Preliminary evidence from our laboratory suggests that downregulation of proteasome activity may be responsible, in part, for driving EMT. Using immortalized human mammary epithelial (HMLE) cells as a model, we show that (1) EMT is associated with decreased proteasome activity and increased polyubiquitinated substrates, (2) pharmacologic inhibition of proteasome activity leads to increased EMT phenotypes and functionality, and (3) pharmacologic inhibition of proteasome activity leads to increased EMT via stabilization of the TGF-β signaling pathway. Together, these data suggest that proteasome activity may be an unappreciated regulator of EMT. Citation Format: Daniel A. Garcia, Asoka Banno, Eric D. Van Baarsel, Patrick J. Metz, Christella E. Widjaja, Stephanie H. Kim, Jack D. Bui, Jing Yang, John T. Chang. Downregulation of proteasome activity promotes epithelial-mesenchymal transition [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1961. doi:10.1158/1538-7445.AM2017-1961
Characterization of Alzheimer Disease Biomarker Discrepancies Using Cerebrospinal Fluid Phosphorylated Tau and AV1451 Positron Emission Tomography (2020)

Suprathreshold CSF P-tau without flortaucipir-PET abnormality may indicate a stage of AD development characterized by early tau abnormality without measurable loss in cognitive performance. Persons with both tau CSF and PET abnormality appear to have reduced cognitive capacities resulting from faster antecedent cognitive decline. Elevation of CSF P-tau appears to precede flortaucipir-PET positivity in the progression of AD pathogenesis and related cognitive decline.
Sonication Derived Powdered Mixtures of Ferrite and Ceramic Nanoparticles for H 2 Generation (2015)

This paper reports sonication derived powdered mixtures of NiFe2O4 and ceramic nanoparticles such as ZrO2/Y2O3/YSZ for H2 generation from thermochemical water-splitting process. To prepare powdered mixtures, NiFe2O4 (75 wt%) and ceramic nanoparticles (25 wt%) were placed in ethanol, sonicated for 120 min, and the slurry obtained was dried at 50°-100°C. Using these powdered mixtures, ten consecutive thermochemical cycles were performed at 900°-1100°C for H2 generation. Among different powdered mixtures, NiFe2O4/ZrO2 produced a maximum H2 of 30.6 mL/g/cycle at NTP conditions. Powdered mixtures prepared with different sonication times (30-120 min) and ZrO2 nanoparticles loadings (10-35 wt%) were also investigated for H2 generation via thermochemical water-splitting process. Sonication derived NiFe2O4/ZrO2 powdered mixture prepared at optimized conditions has produced average H2 volume of 38.8 mL/g/cycle during five consecutive thermochemical cycles, which was found to be higher than the H2 volume generated by NiFe2O4/Y2O3 and NiFe2O4/YSZ powdered mixtures. In addition, these powdered mixtures were characterized for powdered x-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) specific surface area, and scanning and transmission electron microscopy (SEM and TEM).
Effective solution chemistry instruction by integrating live pC–pH diagrams into PowerPoint (2010)

Abstract pC–pH diagrams provide a graphical illustration of chemical speciation as a function of pH and are hence a very effective tool for understanding the chemical system being studied. This understanding can lead to assumptions that simplify problem solving. However, manual construction of pC–pH diagrams for multiprotic systems is cumbersome and is further complicated by non‐standard temperature and ionic strength conditions. As a result, construction of pC–pH diagrams can become the focus of classroom teaching rather than their application to solving real‐world problems. Students tend to get lost in the complexities of pC–pH diagram construction and often fail to appreciate their value in problem solving. To address this limitation, we have developed interactive pC–pH diagrams for mono, di, and triprotic systems that are all bundled into a single PowerPoint file. The governing equilibrium equations are presented adjacent to the pC–pH diagram which makes the entire process transparent. The diagrams update in real‐time when the total concentration and pK a are changed by the user making them universally applicable to any mono, di, or triprotic system. Temperature impact on pK a and the pC–pH diagram can also be examined for some commonly encountered systems. Because of PowerPoint integration, there is no learning curve and specification of pK a is typically all that is required to use these diagrams. A real‐world application of these interactive pC–pH diagrams is presented by examining the solution chemistry in therapeutic protein‐producing mammalian cell bioreactors. The cause of high bioreactor CO 2 concentration and strategies to overcome it were determined just by using the interactive pC–pH diagrams without resorting to numerical calculations. We believe these easy to use and interactive pC–pH diagrams could be more extensively used for problem solving in the classroom simultaneously enhancing student understanding of the chemical system being studied. The PowerPoint file with the pC–pH diagrams is available free of charge for academic use. © 2010 Wiley Periodicals, Inc. Comput Appl Eng Educ 20: 741–749, 2012
Transabddminal Approach for Gracilis Muscle Interposition and Repair of Recurrent Vesicovaginal Fistulae (1987)

No AccessJournal of Urology1 Jun 1987Transabddminal Approach for Gracilis Muscle Interposition and Repair of Recurrent Vesicovaginal Fistulae Jonathan Fleischmann and George Picha Jonathan FleischmannJonathan Fleischmann More articles by this author and George PichaGeorge Picha More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)75686-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Transabddminal Approach for Gracilis Muscle Interposition and Repair of Recurrent Vesicovaginal Fistulae." The Journal of Urology, 137(6), p. 237A © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 137Issue 6June 1987Page: 237A Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Jonathan Fleischmann More articles by this author George Picha More articles by this author Expand All Advertisement PDF downloadLoading ...
Effect of serum proteins and osteoblasts on the surface transformation of a calcium phosphate coating: A physicochemical and ultrastructural study (1998)

Changes occurring at the surface of a calcium phosphate coating when in contact with osteoblasts versus those in acellular solutions were analyzed. The coating studied is one with a well-documented extensive effect on short-term bone growth stimulation. Precipitates associated with original crystals and organized in a weblike structure were observed after a 3-week culture with osteoblasts. The precipitates were identified as carbonated hydroxyapatite (c-HA). In contrast, no significant surface changes were detected after immersion in an acellular serum-containing solution. However, in an acellular serum-free solution simulating the ionic composition of plasma, precipitates, identified as c-HA, were abundantly formed. Dissolution of the original coating preceded precipitation. The data support the hypothesis that dissolution of synthetic calcium phosphate ceramics is an initial step in their transformation to a biologically equivalent apatite, and suggest that both solution-mediated (dissolution-precipitation) and cell-mediated mechanisms are involved in the surface transformation. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 39, 234–243, 1998.
Developing breast lesion detection algorithms for digital breast tomosynthesis: Leveraging false positive findings (2022)

Our results show that actionable FP findings hold useful information for lesion detection algorithms, and our ensemble detection model with multi-depth levels improves lesion detection performance.
SPECT analysis of recent cerebral infarction. (1989)

We measured regional cerebral blood flow and [123I]iodoamphetamine (IMP) uptake in 16 patients with unilateral brain infarcts during the subacute period (Day 3 to Day 50) and again after 3 months. Our results show that the central and peripheral areas described earlier in the chronic period were already differentiated in the subacute period. The central area presented a short phase of luxury perfusion and a longer phase of IMP hyperfixation. The peripheral area showed both a slight regional cerebral blood flow decrease and an early IMP uptake decrease similar to those previously found in the chronic period. Contralateral regional cerebral blood flow during the subacute period, considered normal, was significantly lower than that during the chronic period.
Potential errors in pulse oximetry (1991)

There is no absolute reference for oxygen saturation, although multiwavelength in vitro oximeters are accepted as the 'gold standard'. Regardless of whether fractional or functional saturation is used by manufacturers to calibrate their oximeters, evaluation against fractional saturation is recommended since this is the clinically relevant variable. The use of standard notation and comparisons based on bias and precision is recommended. The accuracy of pulse oximetry is intrinsically limited by the use of only two wavelengths, and is dependent on the initial calibration population. The empirical algorithms used to convert the signal to its 'readout value' and the quality control of hardware may both be important sources of variability between oximeters. Change in blood temperature may introduce errors in pulse oximeter and in vitro oximeter saturation readings, but these will be clinically insignificant. Changes in blood pH should not decrease pulse oximetry accuracy.
Vanadium‐Catalyzed Addition of Propargyl Alcohols and Imines. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sleeve pneumonectomy (2007)

Sleeve pneumonectomy remains a surgical challenge with specific problems of intraoperative surgical and anesthesiologic management. In the present chapter we expose the techniques currently employed in our institution. Sleeve pneumonectomy is associated with a non-negligible mortality, with figures ranging from 8% to 15%. This operation is able to provide microscopic free margins (R0) for the majority of the patients, which is an important prognostic factor. Results in terms of long-term survival are encouraging as overall 5-year survival rates range from 25% to 45%, which is to be considered as a satisfactory result for these patients with a locally advanced cancer. Nodal status is a relevant prognostic factor as patients with N2 disease have survival rates lower than 15%.
"Synthetic axial acquisition" full resolution C-Scan ultrasonic imaging (2006)

This work relates to efficient and low cost acquisition of beamformer data for C-Scan imaging. In our previously described Directly Sampled In-phase and Quadrature (DSIQ) approach (1), as few as one complex sample per array element is used. In the 'Synthetic Axial Acquisition' (SAA) approach presented here, we take advantage of the fact that we use an unfocused transmit beam (plane wave) and are imaging primarily shallow and slowly moving, or static, tissue regions. Over a set of approximately 80 serial transmit / receive firings, each with the receive sampling trigger delay offset by the equivalent of one digital sampling interval, a per channel data record of sufficient length to enable a high quality approximation to conventional delay and sum beamforming using full length channel data records. Depending on the choice of beamforming condition, (center frequency, aperture size and focal depth), the SAA approach yields an approximately 30% improvement in lateral resolution over that achievable with DSIQ. FIELD II based simulations were performed for parameters appropriate for our next generation of 'Sonic Window' DSIQ-based C-Scan imaging system with a 5 MHz Center Frequency, 60 x 60 fully sampled 2D array and a 0.3 mm pitch. (A 1D array simulation was performed in the analyses presented here.) These simulations, which include analysis of the effects of target motion in both the parallel and perpendicular directions with respect to the acoustic beam, indicate that the approach is robust with respect to expected levels of target motion. The SAA approach partially precludes an opportunity for signal averaging that is afforded by the DSIQ approach. However, since the phase coherency of acquired SAA signal samples are accounted for in the beamforming summation, the impact on final image SNR is modest. Keywords-Ultrasound, Beamforming, C-Scan, 2D array
Current State of Clostridium difficile Treatment Options (2012)

Recent reports of reduced response to standard therapies for Clostridium difficile infection (CDI) and the risk for recurrent CDI that is common with all currently available treatment agents have posed a significant challenge to clinicians. Current recommendations include metronidazole for treatment of mild to moderate CDI and vancomycin for severe CDI. Results from small clinical trials suggest that nitazoxanide and teicoplanin may be alternative options to standard therapies, whereas rifaximin has demonstrated success in uncontrolled trials for the management of multiple recurrences. Anecdotal reports have also suggested that tigecycline might be useful as an adjunctive agent for the treatment of severe complicated CDI. Reports of resistance will likely limit the clinical use of fusidic acid and bacitracin and, possibly, rifaximin if resistance to this agent becomes widespread. Treatment of patients with multiple CDI recurrences and those with severe complicated CDI is based on limited clinical evidence, and new treatments or strategies are needed.
Screening Blood Donors for High Titre Antibody to Herpes Varicella‐Zoster (1980)

As a method of increasing supplies of varicella-zoster immunoglobulin, semi-automated screening of blood donors for high titre complement-fixing antibody was initiated. This was compared with the previously used method of donor selection based on a history of varicella or zoster in the past 6 months. About one-third of the "history" donors had titres of greater than or equal to 1 in 64 and generally these levels declined rapidly. In contrast, although only 1.1% of donors in random screening had antibody titres greater than or equal to 1 in 64, these levels usually remained high during repeated donation, enabling the production of pools entirely composed of high titre plasma packs.
Occlusion and infection in broviac catheters during intensive cancer therapy (1983)

Before administration of intensive cytotoxic therapy, 90 central venous catheters were inserted into 80 patients with malignancies. Twenty-seven episodes of bacteremia and fungemia occurred during 96 treatment courses. The majority of these infections were due to gram-positive bacteria (45%) or fungi (22%), although gram-negative organisms accounted for 33%. Catheter occlusion occurred in patients receiving intravenous phenytoin, but blood products could be infused without difficulty. An increase in gram-positive bacteremias in patients with these catheters and drug-induced catheter occlusion must now be appreciated.
Lactate detection by colorimetric measurement in real human sweat by microfluidic-based biosensor on flexible substrate (2019)

In this study, we describe the colorimetric detection of lactate concentration in real human sweat samples, as an indication of the performance of especially athletes, on a microfluidic device fabricated on a microfibrous nonwoven substrate comprising microfluidic channels and detection reservoirs. A narrow group (10 healthy individuals: 5 women and 5 men) within age range of 20–25 was used. The optimization and real sweat studies demonstrated that color formation on the biosensor surface is influenced not only by the enzyme, ABTS, gelatin ratios but also by many parameters such as storage conditions. Usage of real sweat samples showed that simulated samples only have limited similarity with the real samples and their contents can have a significant impact on the biosensor, in our case on color formation. To understand the response better, larger group of human subjects should be examined in detail in terms of effect of sweat properties to biosensor signal.
Adaptive systems with closed-loop reference-models, part I: Transient performance (2013)

This paper explores the transient properties of direct model reference adaptive control with closed loop reference models. The transients are characterized by bounds on the model following error, the rate of change of the adaptive parameter and rate of change of the control input. Both Euclidean and L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> norms are used to characterize this transient behavior.
The trimethylsilyl cationic species as a bulky proton. Application to chemoselective dioxolanation (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe trimethylsilyl cationic species as a bulky proton. Application to chemoselective dioxolanationJih Ru Hwu and John M. WetzelCite this: J. Org. Chem. 1985, 50, 20, 3946–3948Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/jo00220a062https://doi.org/10.1021/jo00220a062research-articleACS PublicationsRequest reuse permissionsArticle Views2030Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sweet Potato Starch Residue as Starting Material To Prepare Polyacrylonitrile Adsorbent via SI-SET-LRP (2014)

Sweet potato starch residue (SPSR) was used as starting material to prepare an eco-friendly adsorbent. SPSR was modified by bromoacetyl bromide to obtain a macroinitiator for surface-initiated single electron transfer-living radical polymerization (SI-SET-LRP) of acrylonitrile (AN) catalyzed by La(0)/hexamethylenetetramine (HMTA) in N,N-dimethylformamide (DMF) in the presence of ascorbic acid (VC). The amidoxime (AO) adsorbent was prepared by the reaction of the graft copolymer bromoactylated sweet potato starch (BSPS)/polyacrylonitrile (BSPS-g-PAN) with hydroxylamine. The maximum adsorption capacity for Hg(II) was 4.03 mmol·g(-1). This simple method provided a novel approach to recycle and reuse agricultural residues for controlling heavy metal pollution.