gebhart/patrepeval huggingface dataset:
Association between Nondominant Unit Total Nucleated Cell Dose and Engraftment in Myeloablative Double-Unit Cord Blood Transplantation (2015)

Sustained hematopoiesis after double-unit cord blood transplantation (dCBT) is mediated by 1 unit in nearly all patients. To investigate the associations between nondominant unit characteristics and neutrophil engraftment, we studied 129 consecutive myeloablative dCBT recipients. Ninety-five percent (95% confidence interval, 90 to 98) of patients engrafted. Detection of the nondominant unit 21 to 28 days after dCBT was not associated with improved neutrophil engraftment. In univariate analyses, nondominant unit characteristics (infused total nucleated cell [TNC] and viable CD3(+) cell doses) were significantly associated with speed and success of neutrophil engraftment as were dominant unit characteristics (infused TNC; viable CD34(+), viable CD3(+), and viable CD3-56(+)16(+) cell doses; and post-thaw CD34(+) cell viability). In multivariate analysis, higher infused TNC dose of the nondominant unit was independently associated with improved neutrophil engraftment, even when this unit did not contribute to donor hematopoiesis. In further subgroup analysis, this association was only evident when the infused viable CD34(+) cell dose of the dominant unit was low (<1.20 × 10(5)/kg). These findings suggest nondominant units mediate a dose-dependent facilitation of engraftment in myeloablative dCBT and support continued investigation of dCBT biology and the clinical practice of dCBT in adults in whom low cell dose grafts are common.
Process evaluation of FATaintPHAT, a computer-tailored intervention to prevent excessive weight gain among Dutch adolescents (2012)

Netherlands Trial Registry, ISRCTN 15743786.
Intraoperative detection of glioma tumor infiltration: Comparative study of FLIm vs MRI-based neuronavigation performance (2023)

The MRI-based neuronavigation fails in detecting gliomas tumor infiltrative edges due to intraoperative brain shift. The intraoperative fluorescence lifetime imaging (FLIm), reported here, provides 7% higher accuracy in detecting infiltrative tumor edges over pre-operative MRI.
Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice. (1995)

T cell early precursors belong to the CD3-CD4-CD8- triple negative (TN) thymocyte population that can be subdivided on the basis of CD44, CD25, and heat-stable Ag (HSA) expression. The kinetics and precursor product relationships of these subsets, as well as of the CD4/8low intermediates, were studied by using pulse labeling with bromodeoxyuridine (BrdUrd). The highest frequencies of DNA-synthesizing cells were found in CD44+CD25+ and CD44-CD25low or CD25- subsets. The major TN cell type (CD44-CD25high), as well as CD44+ CD25-HSAlow early precursors, contained a majority of resting cells. RAG-2-/- mice contained less cells in DNA synthesis than normal mice, and CD44-CD25-/low cells were absent. In female mice transgenic for the anti-HYTCR, CD44-CD25high cells were almost all cycling, but a high percentage of resting cells was found in CD44-CD25- cells. In days following the BrdUrd pulse, there was a reduction in the number of BrdUrd+ cells in most subsets, with the exception of the labeled CD44-CD25high cells that showed a bell-shaped curve. The kinetics and cell size evolution suggest that the majority of these cells do not give rise to CD4+CD8+ cells. In RAG-2-/- cells, the block at the CD44-CD25high stage involved all cells. In TCR transgenic (Tg) mice, no block was seen at the CD44-CD25high stage, suggesting that early expression of a complete TCR receptor precludes the normal selection step. However, another block in the differentiation process was observed at the CD44-CD25- step in TCR Tg mice, suggesting an additional selection point.
The Use of High Pressure Processing as a Pathogen Reduction Tool in Raw Pet Food (2017)

ObjectivesThe Food Safety Modernization Act (FSMA) has established a “zero tolerance” for Salmonella in pet food. The objective of this experiment was to evaluate the effectiveness of High Pressure Processing (HPP) and frozen storage time on the inactivation of non-pathogenic, surrogate bacteria populations in raw pet food.Materials and MethodsApproximately 18 kg of a raw beef pet food was inoculated to a target of 7 logs CFU/g with a 5 strain cocktail of non-pathogenic Escherichia coli (ATCC BAA 1427–31) which was previously validated as a surrogate for Salmonella. The inoculated product was packaged in 227 g individual roll stock packages and shipped to an external facility for HPP application. Inoculated samples were subjected to HPP at 600 mpa for 480 s. After HPP processing, samples were transported on ice to Colorado State University for determination of the remaining microbial population. The samples were randomly assigned to either sampling at 24-hours post-processing (n = 10) or following 5 d of frozen storage at -23°C (n = 10). Raw product samples were serially diluted in BPW and plated onto selective (Violet Red Bile Agar; VRBA; selective for coliforms) and non-selective (Tryptic Soy Agar; TSA) medias for enumeration.ResultsAt 24 h post-processing, following HPP, surviving colonies on VRBA totaled 1.8 logs CFU/g (4.9 log CFU/g reduction) following HPP and frozen storage, surviving colonies on VRBA totaled 0.48 logs CFU/g (6.2 log CFU/g reduction) with 90% of all samples under the detection limit. The TSA survivors totaled 4.8 logs CFU/g (2.1 log CFU/g reduction) 24 h post HPP and totaled 4.6 logs CFU/g (2.3 log CFU/g reduction) post HPP and frozen storage. Data were analyzed using the mixed procedure of SAS (version 9.3; SAS Inst. Inc., Cary, NC) and separated using the PDIFF statement with an ɑ of 0.05.ConclusionHigh Pressure Processing effectively kills pathogenic bacterial strains and causes substantial sub-lethal damage/injury to the bacterial cells, reducing the ability of the bacteria to recover and grow on selective media. Additionally, cellular injury leads to additional lethality in bacterial cells following frozen storage. Therefore, HPP and subsequent frozen storage are effective means of killing significant numbers of bacteria, but these methods do not achieve total death or sterilization. As a result, additional interventions must be investigated to achieve sterility and total destruction of Salmonella.
Test-retest reproducibility of [11C]-l-deprenyl-D2 binding to MAO-B in the human brain (2017)

The present results indicate that k <sub>3</sub> and λk <sub>3</sub> of [<sup>11</sup>C]-L-deprenyl-D<sub>2</sub> are reliable parameters for test-retest reproducibility with healthy subjects both before and after PVEc. The studies with patients of larger sample size are required for further clinical applications.
Distributed channel assignment in Wireless Mesh Networks with guaranteed connectivity (2008)

Using multiple radios/channels in wireless mesh networks (WMNs) can significantly boost the throughput of the network and brings broadband wireless access to more users with reduced cost. However, this requires careful assignment of channels to each radio so that interference due to parallel communications can be minimized and the network is not partitioned. We propose a distributed channel assignment protocol for WMNs to maximize the total number of non-interfering concurrent active links and guarantee the network connectivity. The motivation for maximizing the number of links is to give as much leeway to the routing subsystem as possible. The problem is modeled as a list coloring problem where each channel corresponds to a color. The main idea is to determine the minimum degree spanning tree (MDST) of the network for providing more parallel transmissions and guaranteeing connectivity. The links that are not part of the MDST are assigned channels based on a 5-way handshake protocol to resolve arising conflicting requests in the distributed approach. We validate the performance by comparing our approach to a greedy channel assignment that does not guarantee connectivity.
Completion and Production Results From Alternate-Path Gravel-Packed Wells (1995)

Summary A successful gravel pack requires two things: perforations packed with gravel-pack sand and a completely packed annulus. Failure to obtain either one can result in low productivity and/or a sand-producing gravel pack. Alternate-path gravel packing ensures that the annulus will be completely packed and that all perforations taking fluid will be packed with gravel-pack sand. Alternate-path gravel packing has provided long and highly productive completions without any sand production. This paper presents completion data and production results from 39 wells completed with the alternate-path gravel-pack technique. The completion data include completion length, net perforations, carrier fluid, sand placement outside casing, workover fluid, and return rate during packing. Production results include qualitative discussion of all completions with quantitative results, including permeability-thickness product and skin on select completions.
Optimization of the imaging response of scanning microwave microscopy measurements (2015)

In this work, we present the analytical modeling and preliminary experimental results for the choice of the optimal frequencies when performing amplitude and phase measurements with a scanning microwave microscope. In particular, the analysis is related to the reflection mode operation of the instrument, i.e., the acquisition of the complex reflection coefficient data, usually referred as S11. The studied configuration is composed of an atomic force microscope with a microwave matched nanometric cantilever probe tip, connected by a λ/2 coaxial cable resonator to a vector network analyzer. The set-up is provided by Keysight Technologies. As a peculiar result, the optimal frequencies, where the maximum sensitivity is achieved, are different for the amplitude and for the phase signals. The analysis is focused on measurements of dielectric samples, like semiconductor devices, textile pieces, and biological specimens.
Performance Assessment of Stand Alone Bifacial Solar Panel Under Real Time Conditions (2017)

Bifacial photovoltaic (PV) is a promising renewable energy technology that can increase the power density by harvesting both incident and albedo radiation. Integration of these resources into the power grid can offer benefits including improved energy efficiency and power continuity. This paper examines the performance of bifacial solar panels in the real-time climate of Qatar under winter and summer. The operating conditions such as ambient temperature, albedo and soiling have been studied for bifacial PV cells. Average percentage improvement for energy yield was found to be 4.3% by changing albedo whereas 29.0% performance enhancement was observed by cleaning the panel daily.
Industrial-scale inkjet printed electronics manufacturing—production up-scaling from concept tools to a roll-to-roll pilot line (2014)

An efficient strategy for the up-scaling of processing technology for inkjet printing of silver nanoparticle inks towards industrially relevant manufacturing volumes is described. This has been demonstrated by the roll-to-roll production of fine conductive patterns on polymer foils. Starting with small-scale benchmarking to identify the most suitable ink–substrate combination from a range of commercial products, the processing conditions for inkjet printing and sintering were continuously optimized during three consecutive stages. During each iteration, the scale of the experiments in terms of complexity, time requirement and materials usage was increased, thereby more closely resembling the final industrial-scale production conditions. This increased effort was, however, counterbalanced by limiting the number of necessary experiments by purposeful selection based on the results obtained at the lower levels. In addition, the outcome of each previous iteration round served as a starting point for the optimization during the next higher stage. In this way, it was possible to strongly restrict the number of experiments to obtain valuable information about the most ideal conditions at the final stage, which was a roll-to-roll pilot production line. Following this approach, large-area functional conductive structures on plastic foils could be prepared in a continuous manner at process speeds of up to 10 m min–1. These samples showed promising properties for application in printed electronic devices.
Automated fluorescent analysis procedure for enzymatic mutation detection (1998)

The Enzymatic Mutation Detection (EMD) assay detects mutations or polymorphisms in DNA. The assay procedure takes <1 h and is followed by electrophoretic detection. We report an automated procedure, using fluorescently labeled probe and quantitative analysis on the ABI Prism 377 DNA Sequencer, that improves on earlier methods (1, 2) by eliminating the need for sample purification, shortening the hybridization time, and increasing the signal-to-noise ratio. The EMD assay uses the bacteriophage resolvase T4 endonuclease VII, which cleaves the heteroduplex molecules at the mismatch site, forming two shorter fragments that are resolved by gel electrophoresis. Unlike existing mutation techniques, the EMD method uses a single protocol to identify point mutations, deletions, and insertions for all DNA fragments. Test DNA samples are assayed directly from PCR reactions, and fragments up to 4 kb in size have been assayed successfully. A independent analysis on the p53 tumor suppressor gene from clinical samples has shown 100% sensitivity and 94% specificity. Because the fluorescent EMD assay has been optimized for high signal-to-noise ratios, mutations can be identified in mixed samples containing up to a 20-fold excess of normal DNA.
FADS: Flocking anomalies in data streams (2012)

Anomalies detection in data has gained a lot of attention in many domains due to the increasing number of attempts of fraud. In this paper, a new multi-agent approach to detect anomalies in data exploiting a clustering algorithm, is proposed. Each data item is associated with an agent and the agents are randomly disseminated onto a virtual space where they move following the flocking algorithm. The agents grouping in flocks based on a well-defined concept of similarity of their associated objects. The agents associated with similar objects grouping in flocks, whereas the agents associated with objects dissimilar to each other do not group in flocks. The objects associated with agents do not grouped in flocks represent the anomalies in data. Features of the proposed approach, such as parallelism, asynchronism, and decentralization, makes the algorithm scalable to very large data sets. Experimental results confirm the validity of the FADS algorithm for real and synthetic datasets.
Electrochemistry of CuxSi1−xAlloys in Li Cells (2016)

The structure and electrochemistry in lithium cells of sputtered thin films and ball milled alloys in the Cu-Si system (0 ≤ x ≤ 0.60 in CuxSi1−x) were investigated. Both thin films and ball milled Cu-Si alloys showed the co-existence of amorphous Si and a nanocrystalline Cu3Si phase. The lithiation potential of Cu-Si alloys was found to be significantly shifted to potentials below that of pure Si. In addition, the Cu3Si phase was found to be involved in the electrochemical reaction of the alloys with lithium, however not all of the Si could be reacted with Li to its full theoretical extent. This suggests that a ternary Cu-Li-Si phase may be formed at full lithiation of these alloys.
Molecular Cloning of a Cellulase Gene fromBacillus subtilisand Its Expression inEscherichia coli (1986)

Journal Article Molecular Cloning of a Cellulase Gene from Bacillus subtilis and Its Expression in Escherichia coli Get access Yoshinao Koide, Yoshinao Koide Present address: Amano Pharmacentical Co. Nishiharu-cho, Nishikasugai-gun, Aichi Prefecture 481, Japan. Search for other works by this author on: Oxford Academic Google Scholar Akira Nakamura, Akira Nakamura Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Takeshi Uozumi, Takeshi Uozumi Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Teruhiko Beppu Teruhiko Beppu Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 50, Issue 1, 1 January 1986, Pages 233–237, https://doi.org/10.1080/00021369.1986.10867366 Published: 01 January 1986 Article history Received: 08 October 1985 Published: 01 January 1986
State estimation and control for systems with perspective outputs (2003)

In this paper we consider the problem of estimating the state of a system with perspective outputs. We formulate the problem in a deterministic setting by searching for the value of the state that is "most compatible" with the dynamics, in the sense that it requires the least amount of noise to explain the measured output. We show that, under appropriate observability assumptions, the optimal estimate converges globally to the true value of the state and can be used to design output-feedback controllers by using the estimated state to drive a state-feedback controller. We apply these results to the estimation of position and orientation of a controlled rigid body, using measurements from a charged-coupled-device camera attached to the body.
Relationship Between Carrier-Induced Index Change and Feedback Noise in Diode Lasers (1982)

An improved theoretical analysis of single-mode diode laser dynamics reveals that feedback-induced intensity pulsations and frequency modulation are consequences of the carrier-dependent modal refractive index of the laser cavity. A stability criterion based on injection-locking theory indicates that gain-guided diode lasers are more likely to exhibit feedback-induced pulsations than are index-guided devices. Numerical simulation of feedback-induced noise is shown to be in excellent agreement with previously reported experimental data.
Intestinal anti‐nociceptive behaviour of NK3 receptor antagonism in conscious rats: evidence to support a peripheral mechanism of action (2003)

The involvement of neurokinin receptors in visceral nociception is well documented. However, the role and localization of NK3 receptors is not clearly established. This study was designed to determine whether NK3 receptor antagonists crossing (talnetant) or not (SB-235375) the blood-brain barrier reduce the nociceptive response to colo-rectal distension (CRD) and whether NK3 antagonism reduces inflammation- or stress-induced hypersensitivity to rectal distension. Isobaric CRD and isovolumic rectal distensions were performed in rats equipped with intramuscular electrodes to record abdominal muscle contractions. In controls, CRD induced a pressure-related (15-60 mmHg) increase in the number of abdominal contractions. Both talnetant and SB-235375 [50 mg x kg-1, per oral (p.o.)], which had no effect on colo-rectal tone, reduced the number of contractions associated with CRDs from 30 to 60 mmHg. Three days after rectal instillation of TNBS, abdominal contractions were increased for rectal distension volume of 0.4 mL. This effect was not modified by talnetant (30 mg x kg-1, p.o.). Partial restraint stress increased abdominal contractions at all distension volumes (0-1.2 mL). Talnetant (10 mg kg-1, p.o.) abolished the increase observed for 0.8 and 1.2 mL. These results indicate that peripheral NK3 receptor antagonism reduced nociception associated with CRD and hypersensitivity induced by stress but not inflammation.
An Investigation Of Grinding Characteristics Of Nafeldspar By Means Of The Kinetic Model Parameters (2017)

In this study, the specific rates of breakage (Si) and the primary breakage distribution (Bi,j) values of Na-feldspar were determined for four mono-sized feed fractions; -0.106+0.090 mm, -0.090+0.075 mm, -0.075+0.063 mm, and -0.063+0.045 mm. Batch dry grinding tests were carried out for 0.25 and 0.50 minutes of grinding time by using labratory grinding mill having cylpebs with 10 mm diameter. And then the kinetic model parameters (Si, aT, α, γ and ϕJ) were calculated and presented in a comparative manner for different grinding times.
Chronic Pain and Yoga Therapy (1990)

One of the most baffling phenomena that health practitioners face is Pain. Although modern medicine has acquired some success in understanding and alleviating pain as a symptom, it is still almost completely at a loss when pain itself is the problem. Something like 80% of people who visit a doctor do so because of pain. Yet no doctor can see, touch it or feel it in the same way as the patient does. No medical instrument or machine has been developed to measure it.
The rôle of organic matter in soil fertility (1977)

Abstract Soil organic matter is a very heterogeneous mixture of substances, ranging from plant and root fragments, through the living bodies of the soil organisms, to brown amorphous humic substances produced by their activity. These materials have very different rates of decomposition in the soil and very different effects on the soil tilth and nutrient status. The method of soil cultivation used affects the stabilizing power of a limited addition of plant material. The soil organic carbon content under a well fertilized arable rotation stabilizes at about 1 % on many loam and clay soils. Incorporating a 1 year ley in the rotation or ploughing in all the straw produced may increase this by just under 0.1 %, and using normal farm dressings of farmyard manure by just over 0.1 %. These increases may be additive, but the increases are considerably smaller than this on some soils. Incorporating a 3 year grass ley in a 5 or 6 course rotation increases the carbon by between 0.15 and 0.3%, and there is some evidence that farmyard manure has a greater effect if used in a ley-arable than an all-arable rotation. A 3 year lucerne ley behaves more like a 1 year grass-clover ley except just after it has been ploughed out, though it increases the nitrifiable nitrogen in the soil for several years.
The value of a radiological complete response at MRI after neoadjuvant chemotherapy in breast cancer for disease-free survival. (2012)

Poster: ECR 2012 / C-1519 / The value of a radiological complete response at MRI after neoadjuvant chemotherapy in breast cancer for disease-free survival. by: C. Loo1, K. E. Pengel1, S. Rodenhuis1, J. Wesseling1, M. J. Vrancken Peeters1, H. van Tinteren1, K. Gilhuijs2; 1Amsterdam/NL, 2Utrecht/NL
The undergraduate nursing student evaluation of clinical learning environment: an Italian survey. (2014)

The nursing student evaluations were uniformly positive and related to their positive final marks. A positive ward atmosphere was identified as especially important in this study. These data indicate that a non-hostile and hospitable environment can favour the best clinical learning. We conclude that CLES+T scale can be a useful instrument to explore the clinical climate in all hospital areas and to highlight critical clinical situations.