gebhart/patrepeval huggingface dataset:
Bis(pyridyl)silane and -methanol ligands. 3. A new class of optically active ligands prepared from readily available chiral 2-bromo-6-alkoxypyridines and their application in rhodium-catalyzed hydrosilations and copper(II)-catalyzed cyclopropanations (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBis(pyridyl)silane and -methanol ligands. 3. A new class of optically active ligands prepared from readily available chiral 2-bromo-6-alkoxypyridines and their application in rhodium-catalyzed hydrosilations and copper(II)-catalyzed cyclopropanationsMichael E. Wright, Steven A. Svejda, Myung Jong Jin, and Matt A. PetersonCite this: Organometallics 1990, 9, 1, 136–146Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/om00115a022https://doi.org/10.1021/om00115a022research-articleACS PublicationsRequest reuse permissionsArticle Views440Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Influence of Weather on Low Larkspur (Delphinium nuttallianum) Density (2011)

Delphinium nuttallianum (low larkspur) causes serious cattle losses on mountain rangelands in western NorthAmerica. Risk of cattle deaths is related to density of low larkspurs. Our hypothesis was that warmer winter/springconditions, coupled with below average precipitation, would result in reduced low larkspur density (plants/m2).We measured larkspur density using 4 transects at 4 sites: Collbran and Yampa, Colorado; Huntington, Utah; andCalf Creek (Teton Mountains), Wyoming over a 7-9 year period. Weather data was collected at nearby weatherstations. Larkspur density was often related to previous winter and spring precipitation, with increasedprecipitation resulting in higher plant densities. Higher ambient temperatures during winter and spring wererelated to lower plant densities. Further, there was a relationship between weather during the previous growingseason (May to July) and larkspur density the next year, with warmer temperatures and/or low precipitation relatedto reduce densities at 3 of 4 sites.
Capacity Maximization for Active RIS Assisted Outdoor-to-Indoor Communication System (2023)

In this paper, we aim to implement outdoor-to-indoor communication with the aid of an active reconfigurable intelligent surface (active-RIS), where the active-RIS allows the incoming signal from an outdoor base station (BS) to pass through the surface and be received by indoor users (UEs) after shifting phase and magnifying amplitude. Then, the problem of joint beamforming optimization of the BS and active-ITS is investigated to maximize the system capacity. A computationally efficient algorithm is developed to solve it with suboptimal solutions. Simulations indicate the superiority of the active-RIS and the effectiveness of the proposed algorithm.
On Demand Shape-Selective Integration of Individual Vertical Germanium Nanowires on a Si(111) Substrate via Laser-Localized Heating (2013)

Semiconductor nanowire (NW) synthesis methods by blanket furnace heating produce structures of uniform size and shape. This study overcomes this constraint by applying laser-localized synthesis on catalytic nanodots defined by electron beam lithography in order to accomplish site- and shape-selective direct integration of vertically oriented germanium nanowires (GeNWs) on a single Si(111) substrate. Since the laser-induced local temperature field drives the growth process, each NW could be synthesized with distinctly different geometric features. The NW shape was dialed on demand, ranging from cylindrical to hexagonal/irregular hexagonal pyramid. Finite difference time domain analysis supported the tunability of the light absorption and scattering spectra via controlling the GeNW shape.
Silent Shredder (2016)

As non-volatile memory (NVM) technologies are expected to replace DRAM in the near future, new challenges have emerged. For example, NVMs have slow and power-consuming writes, and limited write endurance. In addition, NVMs have a data remanence vulnerability, i.e., they retain data for a long time after being powered off. NVM encryption alleviates the vulnerability, but exacerbates the limited endurance by increasing the number of writes to memory. We observe that, in current systems, a large percentage of main memory writes result from data shredding in operating systems, a process of zeroing out physical pages before mapping them to new processes, in order to protect previous processes' data. In this paper, we propose Silent Shredder, which repurposes initialization vectors used in standard counter mode encryption to completely eliminate the data shredding writes. Silent Shredder also speeds up reading shredded cache lines, and hence reduces power consumption and improves overall performance. To evaluate our design, we run three PowerGraph applications and 26 multi-programmed workloads from the SPEC 2006 suite, on a gem5-based full system simulator. Silent Shredder eliminates an average of 48.6% of the writes in the initialization and graph construction phases. It speeds up main memory reads by 3.3 times, and improves the number of instructions per cycle (IPC) by 6.4% on average. Finally, we discuss several use cases, including virtual machines' data isolation and user-level large data initialization, where Silent Shredder can be used effectively at no extra cost.
Modeling and mitigation of terrain scattered interference (2002)

This paper addresses issues concerning terrain scattered interference (TSI) or hot clutter. TSI poses a unique adaptive signal processing problem because of the mainbeam interference which cannot be cancelled by adding more spatial degrees of freedom, and because of Doppler effects that result in time dependent covariance matrix which lead to time varying weights and time dependent signal-to-interference plus noise ratio (SINR). Earlier efforts on TSI mitigation such as the work of Brennan et al. (1982) have described TSI as a linear combination of weighted and delayed replicas of a jammer waveform. The obvious solution is to reverse TSI formation process by employing a tap delay line filter (a finite impulse response filter) whose coefficients are chosen according to an adaptive algorithm.
Comorbidity and Primary Treatment for Localized Prostate Cancer: Data From C a PSURE™ (2006)

Patient comorbidities affect decision making regarding treatment for localized prostate cancer. Urologists and other physicians treating this disease appear to evaluate patient comorbidities when selecting treatment options.
Learning to Generate and Edit Hairstyles (2017)

Modeling hairstyles for classification, synthesis and image editing has many practical applications. However, existing hairstyle datasets, such as the Beauty e-Expert dataset, are too small for developing and evaluating computer vision models, especially the recent deep generative models such as generative adversarial network (GAN). In this paper, we contribute a new large-scale hairstyle dataset called Hairstyle30k, which is composed of 30k images containing 64 different types of hairstyles. To enable automated generating and modifying hairstyles in images, we also propose a novel GAN model termed Hairstyle GAN (H-GAN) which can be learned efficiently. Extensive experiments on the new dataset as well as existing benchmark datasets demonstrate the effectiveness of proposed H-GAN model
Glucose and Prednisolone Alter Basic Fibroblast Growth Factor Expression in Peritoneal Mesothelial Cells and Fibroblasts (2001)

The mechanism of peritoneal fibrosis in patients on continuous ambulatory peritoneal dialysis is poorly understood. The production of basic fibroblast growth factor (bFGF) by human peritoneal mesothelial cells cultured in high glucose medium was investigated, and the behavior of peritoneal fibroblasts, as well as the inhibitory effect of prednisolone, was assessed. Reverse transcriptase-PCR and immunocytochemistry showed the expression of glucocorticoid receptors in mesothelial cells. The semiquantitative reverse transcriptase-PCR showed that high glucose medium (4.0%) increased bFGF mRNA by 2.5-fold relative to control medium (0.1% glucose), with 83% suppression of the increase by 1 microM prednisolone. The bFGF protein level in culture supernatant was also increased by 1.5-fold in high glucose medium, with this change showing 45% suppression by 1 microM prednisolone. These effects of prednisolone were prevented by a glucocorticoid receptor antagonist (RU486) in a concentration-dependent manner. The proliferation of peritoneal fibroblasts was increased 1.9-fold by the supernatant of mesothelial cells cultured in high glucose medium, with 85% suppression by 1 microM prednisolone and suppression to 16% below basal proliferation by an anti-bFGF neutralizing antibody (10 microg/ml), whereas proliferation showed a concentration-dependent increase on addition of an anti-transforming growth factor beta-neutralizing antibody. Recombinant bFGF (50 to 1000 pg/ml) likewise caused a concentration-dependent increase of peritoneal fibroblast proliferation and fibronectin release by these cells was also increased (at 50 to 5000 pg/ml). These results suggest the potential importance of bFGF for initiation of peritoneal fibrosis and the possible efficacy of glucocorticoids for preventing such fibrosis in patients receiving peritoneal dialysis.
Spontaneous acute erythroblastic leukaemia (AML-M6Er) in a dog (2011)

A five-year-old golden retriever was presented with anaemia, thrombocytopenia, anorexia and lethargy. Peripheral blood cytology showed abnormal cells similar to proerythroblasts with multiple nucleoli and strongly basophilic cytoplasm. Bone marrow cytopathology revealed that the blast cells accounted for more than 80% of all nucleated cells (ANC). These blast cells were confirmed as erythroblastic cells by cytochemistry, polymerase chain reaction for genetic clonality assessment of IgH and TCRγ, flow cytometry, and transmission electron microscopy. Based on these observations, the dog was diagnosed with acute erythroblastic leukaemia (AML-M6Er). Chemotherapy with cytarabine commenced on day 7 after initial presentation, but the dog died 2 days later. This is the first report of spontaneous AML-M6Er in a dog.
Structure-based design of allosteric calpain-1 inhibitors populating a novel bioactivity space (2018)

Dimeric calpains constitute a promising therapeutic target for many diseases such as cardiovascular, neurodegenerative and ischaemic disease. The discovery of selective calpain inhibitors, however, has been extremely challenging. Previously, allosteric inhibitors of calpains, such as PD150606, which included a specific α-mercaptoacrylic acid sub-structure, were reported to bind to the penta-EF hand calcium binding domain, PEF(S) of calpain. Although these are selective to calpains over other cysteine proteases, their mode of action has remained elusive due to their ability to inhibit the active site domain with and without the presence of PEF(S), with similar potency. These findings have led to the question of whether the inhibitory response can be attributed to an allosteric mode of action or alternatively to inhibition at the active site. In order to address this problem, we report a structure-based virtual screening protocol as a novel approach for the discovery of PEF(S) binders that populate a novel chemical space. We have identified compound 1, Vidupiprant, which is shown to bind to the PEF(S) domain by the TNS displacement method, and it exhibited specificity in its allosteric mode of inhibition. Compound 1 inhibited the full-length calpain-1 complex with a higher potency (IC<sub>50</sub> = 7.5 μM) than the selective, cell-permeable non-peptide calpain inhibitor, PD150606 (IC<sub>50</sub> = 19.3 μM), where the latter also inhibited the active site domain in the absence of PEF(S) (IC<sub>50</sub> = 17.8 μM). Hence the method presented here has identified known compounds with a novel allosteric mechanism for the inhibition of calpain-1. We show for the first time that the inhibition of enzyme activity can be attributed to an allosteric mode of action, which may offer improved selectivity and a reduced side-effects profile.
On the Influence of Material Objectivity on Electroelastic Dissipation in Polarized Ferroelectric Ceramics (1996)

An earlier system of rotationally invariant electroelastic equations for deformable insulators, which was derived from a well-defined macroscopic model, is extended to include the simplest mechanical and electrical viscous-type dissipation. The resulting nonlinear description satisfies the principle of material objectivity. When the resulting description is linearized, the viscous-type linear electrical dissipative variable contains the spin tensor because a biasing polarization is present in the ferroelectric ceramic.
Development of Industrial Process for Optically Active Propanol Derivatives and Their Applications (2007)

As optically active compounds are playing important roles in a living body as diverse components of bioactive materials, they are mainly utilized in the pharmaceutical field. Going with the stream of the huge advance in chiral technology, we have developed the industrial process to produce optically active propanols by stereoselective assimilation of racemic ones with microorganisms. In addition to that, we have industrialized the technology of hydrolytic kinetic resolution catalyzed by chiral salen complex to prepare optically active epichlorohydrin, and expanded our technical field. Furthermore, we have tried to spread our series of optically active C 3 and C 4 compounds derived from such propanol derivatives. In this paper, investigation of the industrial process for not only the optically active basic chiral propanol derivatives but also chiral building blocks and pharmaceutical intermediates will be discussed, combining our efforts to prevent racemization in the reaction and so on.
Surveying theN=40island of inversion with new manganese masses (2012)

High-precision mass measurements of neutron-rich ${}^{57\ensuremath{-}66}$Mn and ${}^{61\ensuremath{-}63}$Fe isotopes are reported. The new mass surface shows no shell closure at $N=40$. In contrast, there is an increase of the two-neutron separation energy at $N=38$. This behavior is consistent with the onset of collectivity due to the occupation of intruder states from higher orbits, in analogy with the well known ``island of inversion'' around $N=20$. Our results indicate that the neutron-rich Mn isotopes, starting from ${}^{63}$Mn, are most likely within the new island of inversion. From the new mass surface, we evaluate the empirical proton-neutron interaction and the pairing gap, both playing a significant role in the structural changes in this region.
The Binding of Polyoxyanthraquinone Mycotoxins, Emodin and Skyrin, to Serum Albumin (1984)

The anthrapuinone mycotoxyins, emodin and skyrin from Penicillium islandicum Sopp, were investigated for their interactions with bovine serum albumin (BSA) using a technique of spectrophotometry in search for their differences in physical properties by which the differences in their in vitro biological activities could be interpreted. BSA produced characteristic spectral alterations of emodin and skyrin in the visible light region, accompanying marked red shift of their absorption maxima. Spectrophotometric titrations of emodin and skyrin with increasing concentrations of BSA gave molar ratios of 2.5 and 5, respectivery, for their binding to BSA. The absorption spectra of emodin and skyrin were affected by pH changes of the system. The pK were significantly shifted to lower pHs in the presence of BSA. The amplitude in the BSA-induced pK shift of skyrin was significantly larger than that of emodin. Sodium dodecylsulfate (SDS) abolished the BSA-induced spectral alterations of emodin and skyrin.
Strain-Gradient Effect in Gas Sensors Based on Three-Dimensional Hollow Molybdenum Disulfide Nanoflakes (2017)

A novel three-dimensional transition metal dichalcogenide (TMD) structure consisting of seamless hollow nanoflakes on two-dimensional basal layers was synthesized by a one-step chemical vapor deposition method. Here, we demonstrate that the as-grown nanoflakes are formed on an organic promoter layer which served as a positive template and are swollen at the grain boundaries by the bubbling effect. TMD nanosheets with hollow nanoflakes are successfully applied as chemical sensors, and it was found that their gas adsorption property is strongly related to the internal strain gradient resulting from the variation in the lattice parameter. This result is consistent with the theoretical prediction in previous studies. Our chemical vapor deposition-based approach is an efficient way to generate TMD-based nanostructures over a large surface area for various practical applications such as chemical sensors.
454 pyrosequencing based transcriptome analysis of Zygaena filipendulae with focus on genes involved in biosynthesis of cyanogenic glucosides (2009)

Pyrosequencing is an attractive approach to gain access to genes in the biosynthesis of bio-active natural products from insects and other organisms, for which the genome sequence is not known. Based on analysis of the Z. filipendulae transcriptome, promising gene candidates for biosynthesis of cyanogenic glucosides was identified, and the suitability of Z. filipendulae as a model system for cyanogenesis in insects is evident.
A New Cycloid Drive With High-Load Capacity and High Efficiency (2004)

A patented double crank ring-plate-type cycloid drive is introduced in this paper. The new drive requires no output unit and places no limit on the size of the tumbler bearing. The drive is able to transfer larger torque than a typical existing planetary cycloid drive. The newly designed double crank ring-plate cycloid drive preserves the standard advantages of planetary pin-cycloid drives. Its working principles, advantages and design issues are discussed. Promising results from prototype testing are presented.
Cytochrome P4502D6 catalyzes the O-demethylation of the psychoactive alkaloid ibogaine to 12-hydroxyibogamine. (1998)

Ibogaine is a psychoactive alkaloid that possesses potential as an agent to treat opiate and cocaine addiction. The primary metabolite arises via O-demethylation at the 12-position to yield 12-hydroxyibogamine. In this report, evidence is presented that the O-demethylation of ibogaine observed in human hepatic microsomes is catalyzed primarily by the polymorphically expressed cytochrome P-4502D6 (CYP2D6). An enzyme kinetic examination of ibogaine O-demethylase activity in pooled human liver microsomes suggested that two (or more) enzymes are involved in this reaction: one with a low KMapp (1.1 microM) and the other with a high KMapp (>200 microM). The low KMapp activity comprised >95% of total intrinsic clearance. Human liver microsomes from three individual donors demonstrated similar enzyme kinetic parameters (mean KMapp = 0.55 +/- 0.09 microM and 310 +/- 10 microM for low and high KM activities, respectively). However, a fourth human microsome sample that appeared to be a phenotypic CYP2D6 poor metabolizer possessed only the high KMapp activity. In hepatic microsomes from a panel of human donors, the low KMapp ibogaine O-demethylase activity correlated with CYP2D6-catalyzed bufuralol 1'-hydroxylase activity but not with other P450 isoform-specific activities. Quinidine, a CYP2D6-specific inhibitor, inhibited ibogaine O-demethylase (IC50 = 0.2 microM), whereas other P450 isoform-specific inhibitors did not inhibit this activity. Also, of a battery of recombinant heterologously expressed human P450 isoforms, only rCYP2D6 possessed significant ibogaine O-demethylase activity. Thus, it is concluded that ibogaine O-demethylase is catalyzed by CYP2D6 and that this isoform is the predominant enzyme of ibogaine O-demethylation in humans. The potential pharmacological implications of these findings are discussed.
Projetos sala virtual de estudos e liga engenharia: integração do wims 4.x ao moodle 3.x (2016)

Propoe-se neste projeto de graduacao a configuracao de um arcabouco tecnologico que contribua efetivamente com a melhoria das condicoes de ensino e de aprendizado em disciplinas do Centro de Tecnologia. O projeto Sala Virtual de Estudos e associado ao projeto LIGA Engenharia, que, por meio de um Ambiente Virtual de Aprendizagem, busca proporcionar um espaco de extensao da sala de aula presencial, oferecendo nao so instrumentos de uso convencional, mas tambem um arcabouco expansivel e que permita agregar tecnologias de dominio especifico. Visa-se, com este espaco, colaborar com a reducao da evasao e das reprovacoes. Devido a complexidade inerente a construcao de um ambiente virtual completo, optou-se, neste 2o ano de projeto, pela adaptacao e especializacao do ambiente Moodle, visto ser este um software de codigo aberto e de larga utilizacao em muitos paises. Este trabalho concentra-se na integracao do ambiente WWW Interactive Multipurpose Server (WIMS) versao 4.x ao Moodle versao 3.x. O WIMS permite a oferta de folhas de exercicios interativos aos alunos, permitindo ao professor construi-las a partir de uma grande base de dados. Os enunciados dos exercicios variam a cada interacao e suas atividades sao registradas, computando notas e permitindo fazer inferencias sobre o status do aluno. A integracao entre os dois ambientes, prototipada em um projeto de pos-graduacao, visa otimizar o acesso dos alunos e professores, que precisam acessar somente o Moodle, e deixar transparentes aos usuarios as atividades realizadas no WIMS. Alem disso, os dados gerados nas atividades do WIMS sao importados para o Moodle, permitindo ao professor gerenciar as notas dos alunos em um unico ambiente, alem de alimentar um Sistema de Recomendacoes em desenvolvimento no escopo dos projetos Sala Virtual de Estudos e LIGA Engenharia. A integracao destes dois ambientes sera aplicada ao servidor Moodle do DETI ate dezembro de 2016, juntamente com os demais recursos em desenvolvimento no projeto.
Enhanced Supercapacitive Behaviors of Birnessite Type Manganese Dioxide (2008)

Abstract not Available.