gebhart/patrepeval huggingface dataset:
Optimal Mixing Rate in Linear Solvent Strength Gradient Liquid Chromatography (2016)

The mixing rate (Rϕ) is the temporal rate of increase in the solvent strength in gradient LC. The optimal Rϕ (Rϕ,Opt) for a gradient analysis is the one at which a required separation capacity and peak capacity of the analysis are obtained in the shortest time. The Rϕ,Opt of LSS (linear solvent strength) gradient LC is found in dimensionless form (rϕ,Opt) expressing Rϕ,Opt in units of hold-up time (t0) and characteristic strength-constant (Φchar). Previously unknown effect of the gradient band compression on the peak capacity is taken into account. The rϕ,Opt depends on the solvent composition range covered by the mixing ramp and on the available pressure. A default rϕ at which the analysis time is contained within 30% margin of its minimum at rϕ,Opt for a broad range of conditions is proposed. As an example, the recommended default for small-molecule samples is 5% increase in the solvent strength per each t0-long increment in time. At this rate, approximately 0.2√N units of peak capacity are generated per each 10% solvent strength increment. The effect of a column kinetic optimization is also evaluated.
PROBLEMS TO SPARE (1998)

SUBTITLE: JUST WHEN APPROVED PARTS ARE BCOMING MORE DIFFICULT TO FIND, THE RULES -- HOPEFULLY -- ARE STARTING TO CHANGE FOR THE BETTER.
VISPATCH: graphical rule-based language controlled by user event (2002)

VISPATCH (VISible event disPATCH) is a graphical rule-based programming language based on event-driven graphics rewriting that is suitable for expressing user interaction. The VISPATCH interpreter can modify rules by other rules as well as graphical objects. This makes it possible to create a programmable interactive system such as a graphic editor.
Examination of coenzyme specificity in clostridial glutamate dehydrogenase by site-directed mutagenesis (2000)

Conference Abstract| June 01 2000 Examination of coenzyme specificity in clostridial glutamate dehydrogenase by site-directed mutagenesis Joanna Griffin; Joanna Griffin 1Department of Biochemistry, University College Dublin, Belfield, Dublin 4, Ireland Search for other works by this author on: This Site PubMed Google Scholar Paul Engel Paul Engel 1Department of Biochemistry, University College Dublin, Belfield, Dublin 4, Ireland Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (3): A73. https://doi.org/10.1042/bst028a073a Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Joanna Griffin, Paul Engel; Examination of coenzyme specificity in clostridial glutamate dehydrogenase by site-directed mutagenesis. Biochem Soc Trans 1 June 2000; 28 (3): A73. doi: https://doi.org/10.1042/bst028a073a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
InPhase (2009)

To supplement existing forms of communication such as telephone and e-mail, this research proposes a new method of communicating "awareness" between people who are separated by long distances. In this paper, we investigate cases where coincidences in daily behaviors lead to casual conversation and thus intimacy and togetherness. We propose a new method of communicating these "happy coincidences" between a pair of remotely located houses. By equipping furniture and appliances such as doors, sofas, refrigerators and televisions with sensors, we developed a system where these items are connected to remote equivalents and their near simultaneous use is communicated.
Redefining acute care surgery (2015)

Peitzman, Andrew B. MD; Sperry, Jason L. MD; Kutcher, Matthew E. MD; Zuckerbraun, Brian S. MD; Forsythe, Raquel M. MD; Billiar, Timothy R. MD; Alarcon, Louis MD; Rosengart, Matthew R. MD; Mohan, Deepika MD; Watson, Gregory MD; Puyana, Juan Carlos MD; Bauza, Graciela MD; Schuchert, Vaishali Dixit MD; Neal, Matthew D. MD Author Information
Repetitive Electron-Beam Controlled Switching (1980)

Previous investigators have demonstrated the feasibility of using an ionizing electron beam to control the conductivity of a gaseous volume-discharge switch. We consider the possibility of using such switches repetitively at high-power levels (up to 1010 W), with switch opening and closing times as short as several nanoseconds. An analysis of the relevant gas chemistry indicates that these requirements can best be met by using a nonelectronegative base gas with a high electron mobility, diluted with a small percentage of an electronegative gas. Detailed chemistry simulations, using the nonelectronegative gas N2 and the electronegative gas O2, are presented to support the analysis.
The coil design of the superconducting MRI magnet (1988)

A program has been developed to optimize the coil configuration of highly homogeneous magnetic resonance imaging (MRI) magnets with primary and canceling coils. To reduce the amount of leakage fluxes generated by the magnet, the ampere-turn ratio for the primary and canceling coils is set to balance their total magnetic moment. To realize a highly homogeneous magnetic field over the imaging space, the configuration of the main coils is designed to compensate for the flux density components up to the tenth order of the inhomogeneous magnetic field induced by the canceling coils.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Cosmological networks (2014)

Networks often represent systems that do not have a long history of study in traditional fields of physics; albeit, there are some notable exceptions, such as energy landscapes and quantum gravity. Here, we consider networks that naturally arise in cosmology. Nodes in these networks are stationary observers uniformly distributed in an expanding open Friedmann-Lematre-Robertson-Walker universe with any scale factor and two observers are connected if one can causally influence the other. We show that these networks are growing Lorentz-invariant graphs with power-law distributions of node degrees. These networks encode maximum information about the observable universe available to a given observer.
Minimizing the Interface-Driven Losses in Inverted Perovskite Solar Cells and Modules (2023)

The inverted p-i-n perovskite solar cells hold high promise for scale-up toward commercialization. However, the interfaces between the perovskite and the charge transport layers contribute to major power conversion efficiency (PCE) loss and instability. Here, we use a single material of 2-thiopheneethylammonium chloride (TEACl) to molecularly engineer both the interface between the perovskite and fullerene-C60 electron transport layer and the buried interface between the perovskite and NiOx-based hole transport layer. The dual interface modification results in optimized band alignment, suppressed nonradiative recombination, and improved interfacial contact. A PCE of 24.3% is demonstrated, with open-circuit voltage (Voc) and fill factor (FF) of 1.17 V and 84.6%, respectively. The unencapsulated device retains >97.0% of the initial performance after 1000 h of maximum power point tracking under illumination. Moreover, a PCE of 22.6% and a remarkable FF of 82.4% are obtained for a mini-module with an active area of 3.63 cm2.
A New Sensitive Enzyme-Linked Immunosorbent Assay (ELISA) for Alemtuzumab Determination: Development, Validation and Application (2007)

Alemtuzumab is a humanized (IgG(1)) rat monoclonal antibody to CD52 antigen and is currently used in the treatment of chronic lymphocytic leukemia (CLL) and other CD52-positive lymphoproliferative disorders. Various techniques have been developed to measure Alemtuzumab levels in human serum/plasma. The authors report on the validation of a very sensitive enzyme-linked immunosorbent assay (ELISA) to measure serum concentrations of the humanized IgG(1) using a rabbit polyclonal antibody specifically produced against the rat sequence of Alemtuzumab after papain digestion. The assay was successfully applied to test the serum samples of patients with B-lymphocyte CLL who received Alemtuzumab subcutaneously. This ELISA assay could be easily used to determine human serum levels of Alemtuzumab pre- and post-treatment to optimize dosing and scheduling and to study the relationship between dose and clinical response.
Rapidly Progressive T Cell Lymphoma Presenting as Acute Renal Failure: Case Report and Review of the Literature (1997)

We describe a case of peripheral T cell lymphoma that is remarkable for its fulminate course and selective targeting of both kidneys. The patient was a 6-year-old girl who was in her usual state of good health until the onset of abdominal pain and fever. She was treated for acute oliguric renal failure and visual disturbances. A renal biopsy was performed. Biopsy findings were interpreted as suggestive of a vasculitic process, and treatment was initiated for a presumptive diagnosis of Wegener's granulomatosis. The patient died 3 days following admission, and autopsy revealed extensive bilateral kidney infiltration by a peripheral T cell lymphoma. The remainder of the body was spared with the exception of mild infiltration of the pulmonary parenchyma and choroid plexus by neoplastic lymphocytes. The neoplastic nature of the disease was confirmed utilizing immunoperoxidase stains and T cell receptor gene rearrangement. Primary renal lymphoma and renal failure attributable to involvement by lymphoma are rare findings that should be considered when other more common causes of renal insufficiency have been excluded. The presenting clinical complaints are generally of short duration, nonspecific, and atypical. Most patients exhibit oliguria. Physical examination may reveal hepatosplenomegaly, lymphadenopathy, and flank and/or abdominal mass(es). Laboratory findings frequently include an elevated serum creatinine, blood urea nitrogen, lactate dehydrogenase, and a mild proteinuria. Electrolyte abnormalities are variably present. Possible radiographic findings include hypodense or hypoechoic renal lesions and diffuse bilateral renal enlargement. Although the prognosis is dismal, survival may be prolonged utilizing current treatment modalities, and rare patients may be "cured" of disease. The clinical presentation, radiological findings, and prognosis of patients with clinically evident renal involvement by non-Hodgkin's lymphoma are discussed.
The β1‐ and β2‐adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat (1986)

The rat isolated right atrium (frequency response) and progesterone-treated rat uterus (relaxation) were used to examine the beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol. In addition, the beta 1-adrenoceptor stimulatory effect of practolol was studied in the right atrium. All the compounds studied caused a concentration-dependent increase in atrial frequency and relaxation of the uterus. The atrial response to pindolol was competitively inhibited by the beta 1-selective blocker pafenolol (10(-7) M), while the beta 2-selective blocker ICI 118551 (10(-8) M) was without effect. Pafenolol (10(-7) M) was also shown to inhibit the atrial frequency effect of alprenolol and oxprenolol. In the uterus, ICI 118551 (3 X 10(-9) M, 3 X 10(-8) M, 3 X 10(-7) M) blocked the pindolol effect with a pKB of 9.28. In addition, ICI 118551 (10(-8) M) competitively inhibited the relaxation of the uterus induced by alprenolol and oxprenolol. For alprenolol (right atrium and uterus), oxprenolol (right atrium), and pindolol (right atrium), the concentrations needed for half-maximal response were significantly greater than those required for occupation of half the receptors. This dissociation was most pronounced for pindolol in the right atrium. In this tissue, 80-85% of the beta 1-adrenoceptors had to be occupied by pindolol to initiate a tissue response corresponding to 50% of the maximal effect generated by the compound. The intrinsic activities of alprenolol, oxprenolol and pindolol (expressed as % of the maximal tissue response to isoprenaline) were significantly higher in the uterus than in the right atrium. The intrinsic activity of the compounds varied between individual preparations and, particularly in the uterus, correlated with the sensitivity of the tissue to beta-adrenoceptor stimulation by isoprenaline. 5 Calculation ofefficacy, relative to isoprenaline, of the partial beta-agonists revealed a beta 2-adrenoceptor selectivity for alprenolol (2.0), oxprenolol (1.4) and pindolol (3.0). 6 It is concluded that weak partial agonists such as alprenolol, oxprenolol and pindolol possess complex beta 1- and beta 2-adrenoceptor stimulatory properties in relation to beta-adrenoceptor occupancy and tissue sensitivity to beta-adrenoceptor stimulation.
Effects of Zinc, Magnesium, and Iron Ions on Bone Tissue Engineering (2022)

Large-sized bone defects are a great challenge in clinics and considerably impair the quality of patients' daily life. Tissue engineering strategies using cells, scaffolds, and bioactive molecules to regulate the microenvironment in bone regeneration is a promising approach. Zinc, magnesium, and iron ions are natural elements in bone tissue and participate in many physiological processes of bone metabolism and therefore have great potential for bone tissue engineering and regeneration. In this review, we performed a systematic analysis on the effects of zinc, magnesium, and iron ions in bone tissue engineering. We focus on the role of these ions in properties of scaffolds (mechanical strength, degradation, osteogenesis, antibacterial properties, etc.). We hope that our summary of the current research achievements and our notifications of potential strategies to improve the effects of zinc, magnesium, and iron ions in scaffolds for bone repair and regeneration will find new inspiration and breakthroughs to inspire future research.
Characterization of a cobalt(II) cyanide complex inside zeolite Y that reversibly binds oxygen (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of a cobalt(II) cyanide complex inside zeolite Y that reversibly binds oxygenRobert J. Taylor, Russell S. Drago, and James E. GeorgeCite this: J. Am. Chem. Soc. 1989, 111, 17, 6610–6615Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/ja00199a020https://doi.org/10.1021/ja00199a020research-articleACS PublicationsRequest reuse permissionsArticle Views269Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reactions of Oxymyoglobin with NO, NO2, and NO2- under Argon and in Air (1996)

Oxymyoglobin under argon reacts with NO2- and NO2 (N2O4) to produce metmyoglobin in a spectrally clean process with clear isosbestic points. In both cases, the reactant is NO2-. The second-order rate constant for NO2- or N2O4 is the same: d(Mb+)/dt = k(MbO2)(NO2-) where k = 0.21 +/- 0.02 L mol-1 S-1. The reaction of MbO2 with NO under argon is a complex process and entails the generation of Mb+ and OONO- (peroxynitrite) in the first step. The latter (lambda MAX, 302 nm) was poorly resolved from more intense protein absorption in the 300-nm region. However, at pH 9, the change in absorbance corresponded exactly to a quantitative production of the OONO-ion. Hydroxy radicals from it were trapped with ethylene-1, 2-(13) C. The initial step is followed in sequence by the rapid formation of MbNO+. The iron(III)-nitrosyl adduct hydrolyzes slowly to MbII and NO2- (k = 8.0 +/- 0.8 x 10(-5) S-1. MbII then rapidly associates with NO, and MbNO is the final product of this reaction. Oxymyoglobin is inert to NO3-. In contrast to the results under argon, in air the reactions of MbO2 with NO2-, NO, and NO2 (N2O4) all proceed in the same autocatalytic fashion with kAVE (for the autocatalytic rates) approximately equal to 9 +/- 5 L mol-1 s-1. Nitrite is the initial reactant in all cases. Isosbestic points are not observed in the visible spectrum, and additional porphyrin iron-ligated species are intermediates. Based upon work with iron porphyrins.
Supplementary Table. S5 from Development of Lung Adenocarcinomas with Exclusive Dependence on Oncogene Fusions (2023)

&lt;p&gt;Supplementary Table. S5. Mutation frequency of the 127 SMGs for 20 cellular processes in the study and TCGA cohort&lt;/p&gt;
Outlier Analysis (2013)

With the increasing advances in hardware technology for data collection, and advances in software technology (databases) for data organization, computer scientists have increasingly participated in the latest advancements of the outlier analysis field. Computer scientists, specifically, approach this field based on their practical experiences in managing large amounts of data, and with far fewer assumptions the data can be of any type, structured or unstructured, and may be extremely large. Outlier Analysisis a comprehensive exposition, as understood by data mining experts, statisticians and computer scientists. The book has been organized carefully, and emphasis was placed on simplifying the content, so that students and practitioners can also benefit. Chapters will typically cover one of three areas: methods and techniques commonly used in outlier analysis, such as linear methods, proximity-based methods, subspace methods, and supervised methods; data domains, such as, text, categorical, mixed-attribute, time-series, streaming, discrete sequence, spatial and network data; and key applications of these methods as applied to diverse domains such as credit card fraud detection, intrusion detection, medical diagnosis, earth science, web log analytics, and social network analysis are covered.
Postoperative Intrathecal Morphine for Analgesia after Major Orthopedic Surgery?: In Response (2004)

We thank Dr. Schricker for his interest in our recent publication. Dr. Schricker’s letter pointed out a typographical error in the case report. This patient’s epidural-intrathecal catheter was removed after the cerebrospinal lavage. The article should have read as follows: “Subsequent postoperative pain was managed with intravenous morphine patient-controlled analgesia” rather than “Subsequent postoperative pain was managed with morphine patient-controlled epidural analgesia.” To clarify, the patient’s postoperative pain therefore, was controlled with intravenous PCA morphine (bolus 1.2 mg, lock-out 8 min, concentration 2 mg/mL). We thank Dr. Schricker for his attentiveness to detail and apologize for any confusion this error may have caused the readers. Ban C. H. Tsui, MSC, MD, FRCPC
Preferential apoptosis of CD56dim natural killer cell subset in patients with cancer (2002)

Natural killer (NK) cells (CD56(+)/CD3(-)) in the circulation of cancer patients were reported to have low NK activity and undergo spontaneous apoptosis. A possible relationship between apoptosis and impaired NK activity was studied by Annexin V-binding and NK-cell assays performed with peripheral blood mononuclear cells of patients with head and neck cancer (HNC), breast cancer (BC) and normal controls (NC). Cells stained with Annexin V (Anx) and antibodies to CD56, CD3, CD95, CD25, CD122 or CD132 were examined by flow cytometry. NK activity was tested against K562 targets in 4-h (51)Cr-release assays. The ratio of CD56(dim)/CD56(bright) NK cells was significantly different in patients vs. controls (10 vs. 16; p<0.01). A significantly greater percentage of CD56(dim) NK cells bound Anx in HNC patients (27+/-17%, median +/- SD) or BC (46+/-18%) than in NC (15+/-18%, p<0.04 and p<0.0002, respectively). CD56(dim) NK cells were preferentially targeted for apoptosis. NK activity was significantly lower in patients with HNC and BC than in NC (p<0.009). An inverse correlation between NK activity and the percent of Anx(+)CD56(dim) NK cells was observed in cancer patients (p =0.002) but not in NC. In patients, circulating CD56(dim) NK cells were targeted for apoptosis, leading to low levels of NK activity.
Filtering and continuously separating microplastics from water using electric field gradients formed electrochemically in the absence of buffer (2021)

Here we use experiments and finite element simulations to investigate the electrokinetics within straight microchannels that contain a bipolar electrode and an unbuffered electrolyte solution. Our findings indicate that in the presence of a sufficiently high electric field, water electrolysis proceeds at the bipolar electrode and leads to variations in both solution conductivity and ionic current density along the length of the microchannel. The significance of this finding is twofold. First, the results indicate that both solution conductivity and ionic current density variations significantly contribute to yield sharp electric field gradients near the bipolar electrode poles. The key point is that ionic current density variations constitute a fundamentally new mechanism for forming electric field gradients in solution. Second, we show that the electric field gradients that form near the bipolar electrode poles in unbuffered solution are useful for continuously separating microplastics from water in a bifurcated microchannel. This result expands the potential scope of membrane-free separations using bipolar electrodes.
Barrier function of the skin in a repetitive irritation model and influence of 2 different treatments* (1996)

The use of bioengineering techniques in this model of mild cumulative irritation allowed us to differentiate the action of both irritants, showing that they act through different mechanisms. The results of the treatments pointed out the need to treat an irritation with the right product for the right time period.
[About the evaluation of school children's health]. (2011)

The information from primary medical documentation and questionnaires of children and their parents concerning the health of children of 12-14 years old is compared. The lack of correspondence is marked between the subjective perception of health (both children and their parents) and the results of comprehensive evaluation of health status based on the medical criteria. The more detailed analysis permitted to mark out a number of possible causes of such a lack of correspondence: absence of changes in general state among children with compensated chronic pathology, subjective overstating of estimate of real level of health by children and parents, hypo diagnostics of certain pathologic states in school children by medical professionals. The results revealed the need in more close attention of pediatricians to the child subjective self-perception of health, active identification of complaints and pathologic symptoms during dispanserization examinations of schoolchildren.