gebhart/patrepeval huggingface dataset:
Release of Some Endogenous Trace Amines from Rat Striatal Slices in the Presence and Absence of a Monoamine Oxidase Inhibitor (1988)

One of the ways of determining whether a particular compound has a role in synaptic transmission is to study the way in which isolated nerve endings accumulate its radiolabelled congener and subsequently release it under resting or stimulated conditions. In the past, this strategy has been used to examine the uptake and release of radiolabeled m-tyramine (mTA), p-tyramine (pTA), and tryptamine (T) (Dyck, 1984; Baker and Dyck, 1986). Most previous studies of the uptake and release of labelled PE and T, in general, have found that these two amines are poorly taken up, poorly retained and that they are released mainly by diffusion rather than by a depolarizing stimulus. In contrast, the more polar amines, mTA and pTA, are actively accumulated, stored and released by depolarizing stimuli in a calcium-dependent manner; i.e., labelled mTA and pTA behave in a manner consistent with the appellation, neurotransmitter. Because radiolabeled congeners do not necessarily give an accurate reflection of the release of endogenous neurochemicals, recent studies attempt to measure basal or stimulated release of endogenous compounds.
The Paradox of Ingestion of Dietary Cholesterol in “Vegans”—Reply (2017)

In a comment on several articles on the vegan dietary pattern, Antoniazzi &amp; Acosta-Navarro (2017) mentioned the paradox of the presence of dietary cholesterol as a nutritional component in the analysis of the vegan dietary pattern [1]. [...].
Self-Activated Ni Cathode for Electrocatalytic Nitrate Reduction to Ammonia: From Fundamentals to Scale-Up for Treatment of Industrial Wastewater (2021)

Electrocatalytic reduction has recently received increasing attention as a method of converting waste nitrate into value-added ammonia, but most studies have focused on complex strategies of catalyst preparation and little has been done in the way of large-scale demonstrations. Herein, we report that in situ activation of a pristine Ni electrode, either on a lab scale or a pilot scale, is effective in facilitating nitrate reduction to ammonia, exhibiting extraordinarily high activity, selectivity, and stability. The self-activated Ni cathode has a robust capacity to reduce nitrate over a wide range of concentrations and achieves great conversion yield, NH<sub>4</sub><sup>+</sup>-N selectivity, and Faradaic efficiency, respectively, 95.3, 95.5, and 64.4% at 200 mg L<sup>-1</sup> NO<sub>3</sub><sup>-</sup>-N and 97.8, 97.1, and 90.4% at 2000 mg L<sup>-1</sup> NO<sub>3</sub><sup>-</sup>-N, for example. Fundamental research indicates that Ni(OH)<sub>2</sub> nanoparticles are formed on the Ni electrode surface upon self-activation, which play crucial roles in governing nitrate reduction reaction (NO<sub>3</sub>RR) through the atomic H*-mediated pathway and accordingly suppressing hydrogen evolution reaction. More importantly, the self-activated Ni(OH)<sub>2</sub>@Ni cathode can be easily scaled up to allow large volumes of real industrial wastewater to be processed, successfully transferring nitrate into ammonia with high yields and Faradaic efficiency. This study demonstrates a new, mild, and promising method of cleaning nitrate-laden wastewater that produces ammonia as a valuable byproduct.
Glass and Medicine: The Larry Hench Story (2016)

The terms “bioactive glass,” “bioactive ceramic,” “bioactive polymer,” and “bioactive metal” are common in the lexicon of the biomaterials scientist today. Each term is inherently understood by the biomaterials and medical device industry. Those terms and their definitions are utilized as positive selling points for very many medical devices. However, merely forty years ago, the term “bioactive” as applied to any material to be implanted in the human body was still something of a laboratory curiosity. It was the invention of one particular glass composition and the discovery over time of how that material behaved that created an entirely new approach with respect to how any material could and should interact with the human body. The invention, of course, by Larry L. Hench helped to revolutionize the field of implantable biomaterials and created the branch of materials known as bioactive materials. This is the brief story of Larry Hench and Bioglass ® .
Phase imaging via sparse coding in the complex domain based on high-order svd and nonlocal BM3D techniques (2014)

The paper addresses interferometric phase image estimation, that is, the estimation of phase modulo-2π images from sinusoidal 2π-periodic and noisy observations. These degradation mechanisms make interferometric phase image estimation a challenging problem. We tackle this challenge by reformulating the true estimation problem as a sparse regression in the complex domain. Following the standard procedure in patch-based image restoration, the image is partitioned into small overlapping square patches. BM3D algorithm equipped with high order SVD (HOSVD) is used to form complex domain frames suitable to sparse representations of the complex-valued data. HOSVD applied to the groups of BM3D data enables the design of spatially variant and data adaptive orthonormal complex domain transforms. The effectiveness of the new sparse coding based approach to interferometric phase estimation, termed Interferometric PHASE via Block matching and High order SVD (InPHASE-BHS) is illustrated in a series of simulation experiments where it outperforms the state-of-the-art.
Elevated soluble Flt1 mediates an anti-angiogenic state in patients with ANCA-associated vasculitis (2010)

International audience
Chemically Stable Polyarylether-Based Metallophthalocyanine Frameworks with High Carrier Mobilities for Capacitive Energy Storage (2021)

Covalent organic frameworks (COFs) with efficient charge transport and exceptional chemical stability are emerging as an import class of semiconducting materials for opto-/electronic devices and energy-related applications. However, the limited synthetic chemistry to access such materials and the lack of mechanistic understanding of carrier mobility greatly hinder their practical applications. Herein, we report the synthesis of three chemically stable polyarylether-based metallophthalocyanine COFs (PAE-PcM, M = Cu, Ni, and Co) and facile in situ growth of their thin films on various substrates (i.e., SiO<sub>2</sub>/Si, ITO, quartz) under solvothermal conditions. We show that PAE-PcM COFs thin films with van der Waals layered structures exhibit <i>p</i>-type semiconducting properties with the intrinsic mobility up to ∼19.4 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> and 4 orders of magnitude of increase in conductivity for PAE-PcCu film (0.2 S m<sup>-1</sup>) after iodine doping. Density functional theory calculations reveal that the carrier transport in the framework is anisotropic, with the out-of-plane hole transport along columnar stacked phthalocyanine more favorable. Furthermore, PAE-PcCo shows the redox behavior maximumly contributes ∼88.5% of its capacitance performance, giving rise to a high surface area normalized capacitance of ∼19 μF cm<sup>-2</sup>. Overall, this work not only offers fundamental understandings of electronic properties of polyarylether-based 2D COFs but also paves the way for their energy-related applications.
Finding Decoherence Free Subspaces Without Process Tomography (2011)

Quantum process tomography (QPT) is a resource intensive task. We present an experiment in which a 3 dimensional decoherence free subspace is experimentally identified using 36 measurements, instead of the 256 measurements required for QPT.
Prediabetes: a must to recognise disease state (2008)

Prediabetes mellitus (PDM) is defined as a state of abnormal glucose homeostasis in which deficiency or resistance to insulin is the hallmark. PDM precedes the development of overt type 2 DM. It is associated with increased mortality and morbidity and thus fits well with the criteria of a disease condition. Framing PDM as a disease and not a risk or a ‘pre’ stage for diabetes is needed to facilitate early management. Aim: This review aims therefore to increase awareness of PDM as a disease state. Methods: To do so, we shall preview guidelines for its diagnosis. Its prevalence and hazards will be then discussed. Finally, we shall elaborate on the current treatment guidelines. Result: Enough evidence support the notion that PDM is a curable disease state. Conclusions: The current recommendations for the treatment of PDM should be adhered. In addition, there is a room for the use of other pharmacological agents.
Caracterización de accesiones de maíz por calidad de granoy tortilla (2004)

La diversidad genética de los grupos raciales ha sido determinada principalmente para caracteres de planta, fisiológicos y agronómicos, pero pocos son los trabajos que relacionan las características de calidad y su uso en la alimentación para la clasificación de germoplasma. En el presente trabajo se caracterizaron 86 accesiones de maíz (Zea mays L.) con base en atributos del grano y su calidad tortillera y su posible uso para la clasificación de genotipos. Las 86 accesiones corresponden a 45 razas y a cinco grupos raciales. Se determinaron características del grano (tamaño, largo, ancho, grosor, gravedad específica, peso de mil granos, dureza) y de calidad tortillera (capacidad de absorción de agua, pérdida de peso, rendimiento de masa y tortilla, y resistencia al corte de tortillas). Se detectó una asociación significativa (P #8804;0.05) dentro de los grupos raciales, tanto en caracteres de grano como en los de calidad tortillera. El análisis de componentes principales permitió diferenciar a los grupos raciales, lo que demostró que los caracteres de calidad tortillera contribuyen a la caracterización adicional de las accesiones, a pesar de la amplia variación genética. Asimismo, se encontró asociación entre grupos de accesiones con base en la clasificación por sus usos en alimentos, lo que corrobora la complementariedad de ambos grupos de atributos en la caracterización de germoplasma.
DEVELOPING MEDIAN BARRIER INSTALLATION GUIDELINES: A BENEFIT/COST ANALYSIS (2005)

Guidelines for the installation of median barriers presented in the American Association of State Highway and Transportation Officials’ (AASHTO) Roadside Design Guide have remained essentially unchanged for over 30 years. In recent years, the need for improved guidance has prompted several States to reevaluate their guidelines and has also precipitated a nationwide research project administered by TRB. The objective of the study, on which this paper is based, was to develop improved guidelines for the use of median barriers on new and existing high-speed, multilane, divided highways in Texas. The purpose of this paper is to present some modeling and benefit/cost analysis results from that study, with focus on the results from a particular data set developed under a “cross-sectional with-without” study design. The highways of interest are those classified as Interstates, freeways, and expressways with 4 or more lanes and have posted speed limits of 55 mph (88 km/hr) or higher. The models employed to estimate medianrelated crash frequencies and severities, including the Poisson-gamma and ordered multinomial logit models, as well as modeling results from a full-Bayes estimation method are presented. Based on the modeling results, a preliminary benefit/cost analysis, in conjunction with some sensitivity analyses, for developing the guidelines for concrete and high-tension cable barriers is described. The paper ends with a discussion on the limitations of this study and potential future extensions.
ChemInform Abstract: SYNTHESIS OF POTENTIAL ANTINEOPLASTIC ANTHRACENEDIONE DERIVATIVES. II. 1,2‐DIHYDROXY DERIVATIVES (1983)

Abstract Die antineoglastische Aktivität der aus dem Anthrachinon (I) über (II) (das als Rohprodukt weiter verarbeitet wird) und die mehrfach geschützten Derivate (III) bzw. (IV) dargestellten Verbindungen (VI) [(VId) = (II) wird rein über (IIIa) erhalten] wird an Mäusen mit experimentell hervorgerufener Leukämie (L 1210) getestet.
Uptake and distribution of nickel and other metals in the hyperaccumulator Berkheya coddii (2003)

Summary Berkheya coddii is a fast‐growing, high biomass nickel (Ni) hyperaccumulator plant that has recently attracted attention for its possible use in the phytoextraction of Ni. The mechanisms of Ni accumulation, however, are not well understood in this plant. Plants were grown hydroponically in varying Ni concentrations to assess the uptake and distribution of Ni, and other metals, at the whole plant level. X‐ray microanalyses (EDXA) of frozen hydrated tissues were conducted to determine the distribution of Ni at the cellular level in the leaves. Most Ni was found in the shoots, especially in the leaves. Leaf Ni concentration increased with age, whereas older stem sections had lower Ni concentrations than new growth. EDXA analyses revealed that the cuticle of the upper epidermis had a significantly higher Ni concentration than the rest of the leaf. The Ni concentrations in the other leaf tissues were not significantly different. This pattern of distribution contrasts sharply with some other hyperaccumulator species that commonly show a preferential accumulation of Ni and other metals in the vacuoles of the epidermal cells.
Circularly-Polarized GNSS Metasurface Antenna with Two Feed Points in a Sub-wavelength Metallic Cavity (2022)

A metasurface-inspired antenna embedded in a metallic cavity is introduced here. It is expected to be integrated on fast moving platforms enduring harsh accelerations and shocks. The metasurface allows enlarging the antenna bandwidth that is intrinsically reduced for small antennas embedded in sub-wavelength metallic cavities. Circular polarization is achieved using two feed points connected the radiating aperture. The proposed antenna covers the E1, L1, B1 and G1 GNSS bands and exhibits a realized gain larger than 4.4 dBic, a half-power beamwidth of 112° and a cross-polarization level better than −20dB over almost the entire upper hemisphere. The numerical results are successfully validated by measurements.
Measuring voice outcomes: state of the science review (2009)

Researchers evaluating voice disorder interventions currently have a plethora of voice outcome measurement tools from which to choose. Faced with such a wide choice, it would be beneficial to establish a clear rationale to guide selection. This article reviews the published literature on the three main areas of voice outcome assessment: (1) perceptual rating of voice quality, (2) acoustic measurement of the speech signal and (3) patient self-reporting of voice problems. We analysed the published reliability, validity, sensitivity to change and utility of the common outcome measurement tools in each area. From the data, we suggest that routine voice outcome measurement should include (1) an expert rating of voice quality (using the Grade-Roughness-Breathiness-Asthenia-Strain rating scale) and (2) a short self-reporting tool (either the Vocal Performance Questionnaire or the Vocal Handicap Index 10). These measures have high validity, the best reported reliability to date, good sensitivity to change data and excellent utility ratings. However, their application and administration require attention to detail. Acoustic measurement has arguable validity and poor reliability data at the present time. Other areas of voice outcome measurement (e.g. stroboscopy and aerodynamic phonatory measurements) require similarly detailed research and analysis.
2,4-Furfurylidene-D-sorbitol and its tetra-methyl ether: synthesis, conformational studies, and radical scavenging activity (2016)

The structure of 1-[2-(furan-2-yl)-5-hydroxy-6-(hydroxymethyl)-1,3-dioxan-4-yl]ethane-1,2-diol] (2,4-furfurylidene-D-sorbitol) and its tetra-methyl ether was established by a detailed NMR analysis. The conformational structure for both compounds was confirmed by in silico studies based both on Density Functional Theory (DFT) and on classical molecular dynamics approaches. The scavenging activity against hydroxyl radicals (OH) of compounds was established by the 2deoxyribose degradation assay.
Realisation of resistive-sheet type wave absorberin 60 GHz frequency band (1994)

The authors present a design chart and a manufacturing process for millimetre-wave absorbers consisting of two spacers and two resistive sheets. The conventional design chart gives sufficient information to enable a desired absorber to be made. On the basis of the chart, a multilayered type absorber was manufactured and it has a significant absorption level (≤ –20 dB) at a wide-frequency range of 46–66 GHz.
Electron-lattice dynamics on Jahn–Teller surfaces in Ag:Xe crystals (1999)

Excitation of the s-p transition of Ag isolated in a Xe crystal leads to a dynamic Jahn–Teller splitting which, in addition to spin-orbit coupling, removes the degeneracy of the excited p orbital. The dynamics on these Jahn–Teller surfaces and the vibrational relaxation leading to strongly Stokes shifted emission bands is studied with 170 fs time resolution. The wave packet dynamics is followed by one-color resonant pump–probe spectroscopy and a recurrence at 1.3 ps after excitation into the upper two states of the triplet is observed. Two-color fluorescence depletion experiments are used to investigate the dynamics during relaxation to the minima of the excited states. Excited state absorption competes with stimulated emission and an energy of the Ag+ state in Xe is deduced to 5.73 eV.
Prevalence of Vulvovaginal Candidiasis and Susceptibility to Fluconazole in Women (2003)

In this study a new method of membrane filtration using a panel of florigenic enzyme substrates to identify and differentiate four major Candida species within 9 to 12 hours was tested for its ability to diagnose vulvovaginal candidiasis. The study subjects were 612 women who were recruited from consecutive patients who attended a gynecological clinic at Ghent University Hospital during a 14-week period. Some subjects had symptoms of vaginitis, but others did not. Each subject underwent a clinical examination including a wet vaginal smear and a vaginal swab, which was placed in transport gel for delivery to the laboratory. The florigenic process involves the formation of a microcolony on a membrane filter over a 9- to 11-hour incubation period. The membrane is cut into five segments, which are impregnated with a buffered solution of a florigenic 4-methylumbilliferyl substrate. After a further incubation period of 30 minutes, during which cleavage of enzyme substrates takes place, the microcolonies are examined under long-wavelength ultraviolet light resulting in blue or orange fluorescence. A positive yeast culture was obtained from the vaginal swabs of 123 of the 612 women (20.1%). Sixty-five of the patients had symptoms of vaginitis (vulvar pruritus and vaginal discharge), and 547 were asymptomatic. Of the 65 symptomatic women, 60% (39 of 65) had a positive KOH wet smear, and 40% (26/65) had a negative KOH result. More than two thirds of the isolated species were C. albicans (68.3%); C. glabrata was found in 16.3%, C. parapsilosis was isolated in 8.9%, and C. humicola, C. krusei, and C. lusitaniae were found in 1.6%, 0.8%, and 0.8%, respectively. The florigenic technique agreed 100% of the time with chromogenic analysis performed as a comparative standard. The highest number of isolated yeasts was found in women with clinical symptoms of candidiasis and a positive KOH test (29 of 35 >1000 CFU/ml). Conversely, women with clinical symptoms and negative KOH test had low numbers of isolated yeasts. When the subjects were divided into subgroups, pregnant women were the most likely, and postmenopausal women with no hormonal replacement therapy were the least likely, to have a positive yeast culture (33 of 103, 32%, P =.045; 15 of 119, 12.6%, P =.003, respectively). Yeast was found in 26.9% of postmenopausal women not taking oral contraceptives (22 of 114), and 14.4% and 14.0% of premenopausal women taking oral contraceptives (16 of 111) or with an intrauterine device (8 of 57), respectively. The rate of yeast colonization was significantly related to the amount of estrogen in oral contraceptives, with the higher concentrations more likely to have positive yeast growth (P =.05). Similarly, yeast colonization in pregnant women grew significantly as pregnancy progressed (P =.05). Twenty-six of the 123 yeast isolates were resistant to fluconazole when subjected to in vitro sensitivity testing.
Supplementary Video D from Genetic Engineering of T Cells to Target HERV-K, an Ancient Retrovirus on Melanoma (2023)

&lt;p&gt;Supplementary Video D. Physical health of mice group with tumor and without HERV-K env-specific CAR+ T-cell treatment.&lt;/p&gt;
Concanavalin A-inducible suppressor cells in regional lymph nodes of cancer patients. (1979)

Regional tumor-draining lymph nodes of 11 of 14 patients with urological tumors and one of four controls studied contained suppressor cell precursors that could be activated by concanavalin A (Con A) to suppress the proliferative response of autologous lymphocytes to Con A. In contrast, no suppression of lymphocyte proliferation by lymph node cells that were not activated with Con A was observed in four patients tested. The suppressive effect was not due to decreased viability or increased release of cold thymidine by Con A-activated cells nor to alteration in the time course of the proliferative response of Con A-activated cells. Mitomycin C treatment of lymph node cells 24 hr after activation did not abrogate their suppressive activity. Peak suppression was observed after 72 hr in culture. The amount of suppression measured could be maximized by treatment of suppressor cells with mitomycin C 24 hr after activation and by washing the cells immediately before pulse labeling with tritiated thymidine. The concentration of Con A required to produce peak suppression varied from patient to patient with optimal doses ranging from 5 to 25 microgram/ml.
Survival Techniques for Computer Programs (2006)

Abstract — Programs developed with standard techniques often fail when they encounter any of a variety of internal errors. We present a set of techniques that prevent programs from failing and instead enable them to continue to execute even after they encounter otherwise fatal internal errors. Our results indicate that even though the techniques may take the program outside of its anticipated execution envelope, the continued execution often enables the program to provide acceptable results to their users. These techniques may therefore play an important role in making software systems more resilient and reliable in the face of errors. I.
Apoptosis and necrosis induction in cancer cells by non-nucleoside reverse transcriptase inhibitors. (2015)

&lt;p&gt;The fraction of apoptotic and necrotic cells after treatment with different NNRTIs in different concentrations was measured by Annexin-V-APC/7AAD staining and flow cytometry. An example of the gating in the FACS plots is shown for untreated (a) and with a toxic concentration of EFV treated cells (b). A curve was fitted through the data points of the total fraction of dead cells and the EC50 was calculated for each drug. The pancreatic cancer cell line BxPC-3 was treated for 72h with (c) EFV, (d) NVP, (e) RPV, (f) ETR, (g) LSV and (h) DLV. The pancreatic cancer cell line Panc-1 was treated for 72h with (j) EFV, (k) NVP and (l) RPV.&lt;/p&gt;
Heat Shock Protein 70 Gene Transfection Protects Mitochondrial and Ventricular Function Against Ischemia-Reperfusion Injury (2001)

HSP70 upregulation protects mitochondrial function after ischemia-reperfusion injury; this was associated with improved preservation of ventricular function. Protection of mitochondrial function may be important in the development of future cardioprotective strategies.