gebhart/patrepeval huggingface dataset:
High Performance Gold Nanorods@DNA Self-Assembled Drug-Loading System for Cancer Thermo-Chemotherapy in the Second Near-Infrared Optical Window (2022)

In terms of synergistic cancer therapy, biological nanomaterials with a second near-infrared (NIR-II) window response can greatly increase photothermal effects and photoacoustic imaging performance. Herein, we report a novel stimuli-responsive multifunctional drug-loading system which was constructed by integrating miniature gold nanorods (GNR) as the NIR-II photothermal nanorods and cyclic ternary aptamer (CTA) composition as a carrier for chemotherapy drugs. In this system, doxorubicin hydrochloride (DOX, a chemotherapy drug) binds to the G-C base pairs of the CTA, which exhibited a controlled release behavior based on the instability of G-C base pairs in the slightly acidic tumor microenvironment. Upon the 1064 nm (NIR-II biowindow) laser irradiation, the strong photothermal and promoted cargo release properties endow gold nanorods@CTA (GNR@CTA) nanoparticles displaying excellent synergistic anti-cancer effect. Moreover, the GNR@CTA of NIR also possesses thermal imaging and photoacoustic (PA) imaging properties due to the strong NIR region absorbance. This work enables to obtaining a stimuli-responsive "all-in-one" nanocarrier, which are promising candidate for bimodal imaging diagnosis and chemo-photothermal synergistic therapy.
[Amineptine-induced cholestatic hepatitis. 5 cases (author's transl)]. (1980)

The authors have observed 5 cases of cholestatic jaundice with cytolysis during treatment with amineptine, a new tricyclic compound recently made available. The responsibility of the drug was virtually certain for the following reasons: (a) there was no other cause of jaundice, such as viral infection, gallstones, toxic agents or association with other hepatotoxic drugs; (b) clinical and biochemical findings were similar in all patients; (c) in 2 patients, reintroduction of the drug after temporary withdrawal resulted in rapid recurrence of the condition, with the same symptoms and course. The shorter delay (2 and 8 days instead of 11 and 18 days) between absorption of amineptine and reappearance of the symptoms in these two patients is suggestive of an immunoallergic mechanism.
Instability Analysis of Rotor Systems With Internal Damping (2002)

This paper describes the instability of a dual rotor system which is caused by internal damping. Transfer Matrix Method is used analytically. The onset of the instability is determined by calculating complex eigenvalue. Internal damping is occurred by viscous characteristic of the shaft material and friction between the disk and the shaft. In single rotor system, internal damping affects the stability in the flexible mode, and instability is occurred beyond the critical speed. In the rigid mode, it does not affect the stability. But, in dual rotor system, it is found that internal damping affects the stability in all modes, and decreases stable area.
Full-field optical coherence tomography using a fibre imaging bundle (2006)

An imaging fibre bundle is demonstrated for spatially-multiplexed probe beam delivery in OCT, with the aim of eliminating the mechanical scanning currently required at the probe tip in endoscopic systems. Each fibre in the bundle addresses a Fizeau interferometer formed between the bundle end and the sample, allowing acquisition of information across a plane with a single measurement. Depth scanning components are now contained within a processing interferometer external to the completely passive endoscope probe. The technique has been evaluated in our laboratory for non-biological samples. Images acquired using the bundle-based system are presented. The potential of the system is assessed, with reference to SNR performance and acquisition speed.
ChemInform Abstract: SYNTHESE DES 3′‐AMIDO‐3′‐DESOXYADENOSIN‐3′,5′‐CYCLOPHOSPHATS (1974)

Abstract Da die biologischen Eigenschaften des Adenosin‐3 ′,5 ′‐cyclophosphats (AMP) besond stark durch Modifizierung des Phosphatringes beeinflußt werden, wird das AMP‐An loge (III) synthetisiert, um festzustellen, ob die biologischen Eigenschaten auch dur den Ersatz des Sauerstoffes durch eine NH‐Gruppe verändert werden.
ChemInform Abstract: AMPHOTERIC LIGANDS. 2. FORMATION AND STRUCTURE OF A NOVEL CARBON‐HYDROGEN‐BOND‐CONTAINING PRODUCT FROM HYDRIDOMANGANESE PENTACARBONYL AND AN AMPHOTERIC LIGAND (1983)

Abstract Die Reaktion des Mn‐carbonyls (I) mit dem Liganden (IIa) liefert das Produkt (IIIa), in dem der amphotere Ligand die Fähigkeit besitzt, gleichzeitig Kohlenstoff und Sauerstoff zu binden.
Identification of a surface antigen, common to murine lung and lewis lung carcinoma, by monoclonal antibody (1984)

Lewis lung carcinoma (3LL) is a spontaneous murine lung carcinoma which preferentially metastasizes into the lung. Monoclonal antibodies (MAb) against 3LL cells were prepared by fusing spleen cells from rats immunized with 3LL and the P3-NSI/I-Ag4 (NSI) plasmacytoma. Two hybridomas were selected which secreted antibodies capable of preferential binding to 3LL cells and not to other malignant cells. Immunohistochemical staining of sections prepared from various mouse organs with one of the MAbs (22.2), revealed exclusive staining of the lung tissue. The data suggest that a lung-specific, 3 LL-associated antigen, is detected by the 22.2 MAb on 3LL cells. The 22.2 antigen is a surface molecule, and is stable following trypsin treatment and fixation by glutaraldehyde or picric acid. Cells that were prepared from a subcutaneous tumor or from lung metastases express high amounts of 22.2 antigen compared to cells of the culture 3LL line (3LLC). Upon reinoculation of 3LLC cells into mice there was a gradual increase in 22.2 antigen expression. It was possible to select from the heterogeneous 3LLC cell population several clones which express high amounts of antigen. These clones differed also in their metastatic patterns. However, the metastatic capacity of these clones did not correlate with expression of the 22.2 antigen. Thus, it appears that expression of the 22.2 antigen is not a necessary condition for formation of lung metastases by 3LL.
Exposure to Direct and Scatter Radiation with Use of Mini-C-Arm Fluoroscopy (2007)

The surgical team is exposed to minimal radiation during routine use of mini-c-arm fluoroscopy, except when they are in the direct path of the radiation beam.
[CaCO3 stimulates alpha-ketoglutarate accumulation during pyruvate fermentation by Torulopsis glabrata]. (2003)

A large amount of alpha-ketoglutarate (alpha-KG) (6.8 g/L) was accumulated in flask culture when CaCO3 was used as a buffering agent in the production of pyruvate by multi-vitamin auxotrophic yeast Torulopsis glabrata CCTCC M202019. In a 5 L jar-fermentor, less alpha-KG (1.3 g/L) was produced when NaOH was used to adjust the pH, while more alpha-KG (11.5 g/L) detected when CaCO3 was used as the buffer. In the latter case, the molar carbon ratio of pyruvate to alpha-KG (C(PYR)/ CalphaKG) was similar to that obtained in flask culture, suggesting the accumulation of alpha-ketoglutarate was related to the addition of CaCO3. Furthermore, it was found that: (1) delaying the addition time of CaCO3 decreased the a-ketoglutarate formation but increased C(PYR)/ C(alphaKG); and (2) under vitamin limitation conditions increasing the concentration of CaCO3 led to an increased a-KG accumulation at the expenses of pyruvate. To study which ions in CaCO3 was responsible for the accumulation of alpha-KG, the effects of different pH buffers on the a-KG accumulation were studied. The level of alpha-KG was found to correlate with the levels of both Ca2+ and CO3(2-), with Ca2+ played a dominant role and CO3(2-) played a minor role. To find out which pathway was responsible for the accumulation of alpha-KG, the effects of biotin and thiamine on alpha-KG accumulation was investigated. The increase in biotin concentration led to an increase in alpha-KG accumulation and a decrease in C(PYR)/ C(alpha-KG), while the levels of alpha-KG and C(PYR)/C(alphaKG) were not affected by thiamine concentration. The activity of pyruvate carboxylase was increased as much as 40% when the medium was supplemented with Ca2+ . On the other hand, the activity of the pyruvate dehydrogenase complex was unaffected by the presence of Ca2+. To conclude, the higher level of a-KG was caused by higher activity of pyruvate carboxylase stimulated by Ca2+, with CO3(2-) served as the substrate of the reaction.
Initial experience with purely laparoscopic living-donor right hepatectomy (2018)

Purely laparoscopic donor hepatectomy differs from open donor hepatectomy in terms of angle and caudal view. Therefore, surgeons experienced in open donor hepatectomy must gain adequate experience in laparoscopic liver surgery and make adjustments when performing PLDRH.
Remarkable SHG enhancement by helical distributed feedback cavity spontaneously formed in ferroelectric liquid crystals (2000)

Remarkable enhancement of second-harmonic (SH) generation in a ferroelectric liquid crystal was theoretically studied. The enhancement occurs when SH wavelength coincides with the wavelength at odd-number-th dips of subsidiary oscillation in one edge of the selective reflection band. To interpret this behavior, the electric field of inhomogeneous and homogeneous SH light in a cell was simulated for a right-handed (R) ferroelectric liquid crystal. It was found that R-circularly polarized light forms a standing wave inside the cell at the odd-number-th dips, when two counter-propagating beams with the same polarization (e.g., R-R) are incident. On the other hand, inhomogeneous and homogeneous waves are out of phase to each other at the bounding surface at the even-number-th dips, so that no enhancement occurs. As for an incidence of R- and L-polarized light, enhanced SH light is generated only toward the R-incidence side. The SH light is L-polarized in this case, while R-polarized SHG is observed from both sides for the incidence of counterwaves with the same polarization.
Uvulopalatopharyngoplasty for obstructive sleep apnea: A community's experience (1992)

Uvulopalatopharyngoplasty (UPPP) has become an accepted method for treating obstructive sleep apnea (OSA), with a reported success rate as high as 77%, depending upon inclusionary and outcome criteria. The authors reviewed the records of 90 patients with moderately severe OSA (apnea plus hypopnea index [AHI] greater than 20) who underwent UPPP at either a private community or an academic hospital. Forty percent of patients experienced more than a 50% reduction in their AHI with UPPP. Only 22 (24%) of the patients had a postoperative AHI less than 50% of the preoperative AHI and less than 20, i.e., met the authors' criteria for surgical success. The success rate for community otolaryngologists was no different than that achieved in the academic institution. When data from previously published reports were analyzed using these criteria for success, similar results were observed. This study suggests that the effectiveness of UPPP performed by the general otolaryngologic community is equivalent to that reported in the literature. However, more rigorous criteria must be applied to UPPP when evaluating its results and in counseling potential candidates for this procedure.
Double-Shot 3-D Displacement Field Measurement Using Hyperspectral Interferometry (2018)

A combination of a Michelson interferometer, a micro-optic element and a hyperspectral imager is used with broadband illumination to measure depth-resolved out-of-plane displacements without any scanning. Reference and deformed states of a transparent sample are recorded in single shots and used to evaluate the displacement field at different interfaces.
Vibration signal processing for spall size estimation in rolling element bearings using autoregressive inverse filtration combined with bearing signal synchronous averaging (2017)

The main challenging area in the health monitoring of rolling element bearings is the quantification of the spall size using vibration data analysis. This is very crucial for maintenance planning and management decisions. In this article, we present a signal processing scheme for estimating spall sizes in rolling element bearings using autoregressive inverse filtration combined with bearing signal synchronous averaging. The squared envelope of the synchronously averaged signal and its autocorrelation function are used to estimate the spall size. The focus of the preprocessing algorithm using autoregressive inverse filtration resides in enhancing the weak step response events originating from the entry of a rolling element into the spalled region and balancing these with prominent impulse responses which occur when a rolling element strikes the trailing edge. Preprocessing is attained through whitening the shaft order tracked (angular resampled) signal using an autoregressive model based on the shaft synchronously averaged part (autoregressive inverse filtration). Autoregressive inverse filtration is compared to autoregressive filtration based on the raw vibration signal. The selection of the autoregressive model order is realized using Akaike criterion. The efficacy of the two autoregressive filtration algorithms is established by comparing time-domain signals, bearing signal synchronous averages, and their squared envelopes and autocorrelation function. This is done on simulated signals with well-known characteristics and on two sizes of naturally originated and propagated inner race spalls from a high-speed test rig. The sizes of these faults were large in a sense that the rolling element did not bridge over the spall, and this required an adjustment to the size quantification equation to fit this case, which has not been presented before. The combination of autoregressive inverse filtration and the squared envelope of the bearing synchronous averaging gives a superior enhancement to the step response and balances it with the impulse response. This provides the best accuracy in estimating the size of the spall, and unlike other existing algorithms, there exist no need for further processing using wavelets for instance.
Estimating methane emission and oxidation from two temporary covers on landfilled MBT treated waste (2009)

International audience
Hierarchical Structure of Astronomical Objects in the Cosmic String Scheme (1999)

The hierarchical structure of astronomical objects is investigated in the cosmic string scheme with cold dark matter (CDM). A non-linear dark matter potential is formed in the crossing site of three wakes triggered at around &lt;it&gt;z&lt;/it&gt;&lt;inf&gt;i&lt;/inf&gt; by moving strings. If we use this scheme, the mass and radius of formed CDM objects increase gradually as &lt;it&gt;M&lt;/it&gt; ∝ (1+&lt;it&gt;z&lt;/it&gt;)−3 and &lt;it&gt;R&lt;/it&gt; ∝ (1+&lt;it&gt;z&lt;/it&gt;)−2, and objects triggered at &lt;it&gt;z&lt;/it&gt;&lt;inf&gt;i&lt;/inf&gt; &amp;sime; 104, 105 and 106 grow to become objects corresponding to clusters of galaxies, galaxies and dwarf galaxies, respectively. The number densities of these objects &lt;it&gt;n&lt;/it&gt;(&lt;it&gt;z&lt;/it&gt;&lt;inf&gt;i&lt;/inf&gt;) are related to the size &lt;it&gt;l&lt;/it&gt;(&lt;it&gt;z&lt;/it&gt;&lt;inf&gt;i&lt;/inf&gt;, &lt;it&gt;z&lt;/it&gt;) as &lt;it&gt;n&lt;/it&gt;(&lt;it&gt;z&lt;/it&gt;&lt;inf&gt;i&lt;/inf&gt;) ∝ 1/&lt;it&gt;l&lt;/it&gt;(&lt;it&gt;z&lt;/it&gt;&lt;inf&gt;i&lt;/inf&gt;, &lt;it&gt;z&lt;/it&gt;)3, where &lt;it&gt;l&lt;/it&gt;(&lt;it&gt;z&lt;/it&gt;&lt;inf&gt;i&lt;/inf&gt;, &lt;it&gt;z&lt;/it&gt;) is the horizon size of the stage &lt;it&gt;z&lt;/it&gt;&lt;inf&gt;i&lt;/inf&gt; observed at &lt;it&gt;z&lt;/it&gt;. One of the interesting points of this scheme is that smaller objects are gradually accreted into larger ones. For example, dwarf galaxies have been mostly accreted into galaxies at the present. Galaxies are still now accumulating toward clusters of galaxies, and consequently many of accreted galaxies are found as E or SO type galaxies there. In the future, or possibly even at the present time, clusters of galaxies will be accreted into superclusters of galaxies triggered at &lt;it&gt;z&lt;/it&gt;&lt;inf&gt;i&lt;/inf&gt; &amp;sime;103. Heating through the accumulation of baryonic matter in the CDM gravitational potential is also investigated and it is found that their heating is not sufficient to reionize the universe before &lt;it&gt;z&lt;/it&gt;&amp;sime;5. Therefore some other heating sources or mechanisms are required. However, heating through the accumulation of baryonic matter could explain the X-ray properties of clusters of galaxies.
Electronic properties of solution-processed Cu(In,Ga)(S,Se)2 solar cells using metal chalcogenides and amine-thiol solvent mixtures (2018)

This work examines the effects of post-deposition air-annealing on the electronic properties of solution-processed heterojunction CIGS solar cells. The annealing in air of the CIGS/CdS interface was found to have positive effects on the device performance with an increase in all PV parameters even after annealing times as short as 5 min. A VOC increase of <; 130 mV was caused by the reduced surface and grain boundary recombination through passivation of surface Se deficiencies with oxygen atoms. Prolonged annealing causes charge redistribution and diffusion of mobile elements such as Cu and Cd deeper into the absorber bulk however, resulting in lower carrier density and deeper defects with increased annealing time. These were observed through capacitance-voltage profiling and admittance spectroscopy.
Order–disorder and ionic conductivity in calcium nitride-hydride (2023)

Recently nitrogen-hydrogen compounds have successfully been applied as co-catalysts for mild conditions ammonia synthesis. Ca<sub>2</sub>NH was shown to act as a H<sub>2</sub> sink during reaction, with H atoms from its lattice being incorporated into the NH<sub>3</sub>(g) product. Thus the ionic transport and diffusion properties of the N-H co-catalyst are fundamentally important to understanding and developing such syntheses. Here we show hydride ion conduction in these materials. Two distinct calcium nitride-hydride Ca<sub>2</sub>NH phases, prepared via different synthetic paths are found to show dramatically different properties. One phase (β) shows fast hydride ionic conduction properties (0.08 S/cm at 600 °C), on a par with the best binary ionic hydrides and 10 times higher than CaH<sub>2</sub>, whilst the other (α) is 100 times less conductive. An in situ combined analysis techniques reveals that the effective β-phase conducts ions via a vacancy-mediated phenomenon in which the charge carrier concentration is dependent on the ion concentration in the secondary site and by extension the vacancy concentration in the main site.
Radiation-induced micronuclei in p53-deficient and normal mice (1994)

Posttransplant lymphoproliferative disorders are a spectrum of lymphoproliferative disorders seen in recipients of solid-organ, bone marrow, and stem cell allografts. They include polyclonal early lesions mimicking infectious mononucleosis and monoclonal proliferations of B and T cells, indistinguishable from lymphomas occurring in immunocompetent individuals. Although most posttransplant lymphoproliferative disorders are B-cell neoplasms, T-cell posttransplant lymphoproliferative disorders are very rare. Among solid-organ transplants, renal allografts have low risk for development of posttransplant lymphoproliferative disorders. We describe the case of an adult male who developed a T-cell posttransplant lympho?roliferative disorder involving the small intestine after renal transplant, which was diagnosed as peripheral T-cell lymphoma, not otherwise specified.
Placement of a Collagen Glaucoma Drainage Device to Control Intraocular Pressure and Chronic Iritis Secondary to Juvenile Rheumatoid Arthritis (2002)

A patient with juvenile rheumatoid arthritis and chronic iritis is reported with intraocular pressure near 30 mm Hg and previous episodes of intraocular pressure as high as 50 mm Hg despite maximally tolerated medical therapy. Because of the potential risk involved with a full-thickness filtration procedure, it was decided that a nonpenetrating deep sclerectomy would be appropriate, followed by placement of a collagen glaucoma drainage device to maintain aqueous outflow. Immediately postoperatively, intraocular pressure was stabilized. At 24 months postoperatively, intraocular pressure was well controlled at 15 mm Hg with patient receiving only Lotemax. No significant complications were noted at any point in the postoperative course. Because of the patient's predisposition for serious complications frequently associated with trabeculectomy, nonpenetrating deep sclerectomy with the collagen glaucoma drainage device was an effective alternative for this patient.
Selective N-Benzylation of Amino Acids under Homogeneously Catalyzed Hydrogenation Conditions (2004)

Correction to: Selective N-Benzylation of Amino Acids under Homogeneously Catalyzed Hydrogenation ConditionsSynlett 2004; 2004(11): 1961-1962DOI: 10.1055/s-2004-830855
Adapting to the driving context in congestion control for vehicular networks (2014)

Vehicular safety applications require reliable reception of basic safety messages (BSMs), which are broadcast from their neighbours. These messages contain position, mobility, and other information about the vehicle state critical for the operation of envisioned safety-enhancing applications. The scalability of future vehicular networks depend on a suitable congestion control method to handle instances where high node density results in excessive load on the shared control channel, degrading network performance and reducing the safety level of vehicles. When network congestion is detected, these algorithms reduce the offered load by adapting transmission parameters such as the rate and the power. Early works aimed for a fair distribution of network resources in their adaptation of transmission parameters. More recent works recognized that different driving contexts may warrant preferential allocation of resources to nodes in more potential danger. However, existing methods allow users to relate the driving context to a corresponding share of the network resource, rather than a certain quality of service (QoS) level. In this work, we propose a method of representing the driving context as a maximum delay profile. A probabilistic bound on the violation of this delay profile form a QoS requirement between neighbouring nodes. We propose a simple way to incorporate these constraints into an additive-increase multiplicative-decrease congestion control algorithm, which requires minimal amount of packet header overhead. We study its performance by comparing it with a recent AIMD algorithm through simulations and demonstrate its improved fairness in terms of constraint satisfaction probability.