gebhart/patrepeval huggingface dataset:
Shedding patterns in swine of virulent and attenuated pseudorabies virus (1983)

Shedding patterns of 2 virulent (P-2208 and KC-152-D) and 1 attenuated (BUK) strains of pseudorabies virus (PRV) were determined in groups of intranasally inoculated feeder pigs. Clinical signs observed following inoculation with the P-2208 and KC-152-D strains included increase in rectal temperatures up to 42.2 C, anorexia, severe respiratory disturbance, and fatal CNS signs in 2 cases. Clinical signs in pigs inoculated with 7.2 X 10(7) median tissue culture infective dose (TCID50) of the BUK strain were limited to depression and a rise in rectal temperatures to 40.5 C for 3 to 4 days. Evaluation of the efficacy of the virus isolation method used showed that the presence on swabs of only 12.5 TCID50 of the P-2208 strain or 8.4 TCID50 of the BUK strain resulted in a 50% chance of virus recovery. Intranasal inoculations with 500 TCID50 of the P-2208 or KC-152-D strain did not result in synchronous infection of the whole group. Intranasal inoculations with 5,000 TCID50 of the KC-152-D strain or 50,000 TCID50 of the P-2208 strain resulted in continuous virus shedding in all pigs between postinoculation days (PID) 4 and 13 (KC-152-D strain) or 14 (P-2208 strain). Some of the pigs in these 2 groups further shed the P-2208 or KC-152-D strain in a continuous or discontinuous pattern up to PID 19 (P-2208 strain) or 20 (KC-152-D strain). The time of onset or the level of virus neutralizing antibody production in individual pigs was not found to have an influence on their shedding patterns.(ABSTRACT TRUNCATED AT 250 WORDS)
Crystal Structure of the Catalytic Domain of Drosophila β1,4-Galactosyltransferase-7 (2010)

The beta1,4-galactosyltransferase-7 (beta4Gal-T7) enzyme, one of seven members of the beta4Gal-T family, transfers in the presence of manganese Gal from UDP-Gal to an acceptor sugar (xylose) that is attached to a side chain hydroxyl group of Ser/Thr residues of proteoglycan proteins. It exhibits the least protein sequence similarity with the other family members, including the well studied family member beta4Gal-T1, which, in the presence of manganese, transfers Gal from UDP-Gal to GlcNAc. We report here the crystal structure of the catalytic domain of beta4Gal-T7 from Drosophila in the presence of manganese and UDP at 1.81 A resolution. In the crystal structure, a new manganese ion-binding motif (HXH) has been observed. Superposition of the crystal structures of beta4Gal-T7 and beta4Gal-T1 shows that the catalytic pocket and the substrate-binding sites in these proteins are similar. Compared with GlcNAc, xylose has a hydroxyl group (instead of an N-acetyl group) at C2 and lacks the CH(2)OH group at C5; thus, these protein structures show significant differences in their acceptor-binding site. Modeling of xylose in the acceptor-binding site of the beta4Gal-T7 crystal structure shows that the aromatic side chain of Tyr(177) interacts strongly with the C5 atom of xylose, causing steric hindrance to any additional group at C5. Because Drosophila Cd7 has a 73% protein sequence similarity to human Cd7, the present crystal structure offers a structure-based explanation for the mutations in human Cd7 that have been linked to Ehlers-Danlos syndrome.
Applications of HMM in Protocol Anomaly Detection (2009)

A protocol anomaly detection model based on hidden Markov model (HMM) is given in this work which can verify normal and abnormal traffic. Then we demonstrate the model's correctness and effectiveness by using MIT Lincoln Laboratory 1999 DARPA Intrusion Detection Evaluation Data Set.
Fluorescence and Energy Transfer of Polypeptides Containing Naphthyl Groups in Their Side Chains (1977)

Energy transfer in the singlet state was studied in solution at 25 degrees C for poly(beta-1-naphthylmethyl L-aspartate) and copolymers of beta-1-naphthylmethyl L-aspartate and gamma-benzyl L-glutamate. Transfer efficiencies, migration coefficients, migration lengths, and interaction radii were determined from the quenching studies using biacetyl as a quencher. The migration coefficient increases with increasing naphthyl groups in the copolymers. This means that singlet energy migrates among more naphthyl groups with increasing naphthyl groups in the polymer chain. Interaction radius for the fluorescence quenching by biacetyl was estimated to be in the range of 5.8 to 8.9 A irrespective of whether energy donor is monomer or excimer. Moreover, it was shown that energy migration via excimer does not take place and energy of the excimer is localized.
A Flexible Context Architecture for a Multi-User GUI (2011)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
Ground Facility Prototype Development to Support High-Integrity Aircraft Approach and Landing Using GPS (2002)

The Local Area Augmentation System (LAAS) is an augmentation of the Global Positioning System (GPS) to allow for precision approach and landing at airports. Stanford University has, with support from U.S. Federal Aviation Administration (FAA), developed a real time prototype of the LAAS Ground Facility (LGF) known as the Integrity Monitor Testbed (IMT). It is used to evaluate whether the LGF can meet the integrity and continuity requirements that apply to aircraft Category I precision approach (i.e. close to the runway, but non-zero visibility). The first generation IMT system was designed in the mid-1990s. Since that date computational power and, to a somewhat lesser extent, receiver technology has evolved dramatically. The dated processing platform and Radio Frequency (RF) hardware limit further progress. Therefore, a transition to a new and improved system is needed to further continue development and testing for Category I precision approach and to use as a starting point for Category II/III LGF development. This thesis describes the design goals and motivation behind the second-generation IMT system, known as IMT2. The hardware upgrade involves new L1/L2 antennas, low-loss antenna cables, new L1 and L2-upgradeable GPS receivers, and a new computer platform. Considerable effort was placed on the computer platform as this is the element that has experienced the most advanced since the first prototype. The computer platform was designed to provide additional flexibility, incorporated new GPS hardware, and enhance the development environment. One key element of the upgrade has been the addition of new software to communicate with the receivers. This function, known as Signal-in-Space Receive and Decode 2 (SISRAD2), is now a modular means of integrating different receiver types, providing synchronization of receiver measurement packets, and fits the measurement packets into a single IMT2 data format.
Stand und Entwicklung des Nitrierens von Aluminium- und Titanlegierungen (2000)

There are significant differences between the nitriding behaviour of aluminium, titanium and iron alloys through the different solubility of nitrogen in the base metal, the nitriding temperature in relation to the solidus temperature and the affinity of the base metal to oxygen. In recent years a considerable progress has been made in the field of plasma nitriding of aluminium alloys. An essential part of this is the evidence that commercial plants can be used for the plasma nitriding of aluminium alloys. New possibilities for the production of load-specific nitrided layers on titanium alloys offers the intensification of the nitriding process and the combination of the nitriding with solution treatment and subsequent aging.
Host multicast: a framework for delivering multicast to end users (2003)

While the advantages of multicast delivery over multiple unicast deliveries is undeniable, the deployment of the IP multicast protocol has been limited to "islands" of network domains under single administrative control. Deployment of inter-domain multicast delivery has been slow due to both technical and administrative reasons. In this paper we propose a Host Multicast Tree Protocol (HMTP) that (1) automates the interconnection of IP-multicast enabled islands and (2) provides multicast delivery to end hosts where IP multicast is not available. With HMTP, end-hosts and proxy gateways of IP multicast-enabled islands can dynamically create shared multicast trees across different islands. Members of an HMTP multicast group self-organize into an efficient, scalable and robust multicast tree. The tree structure is adjusted periodically to accommodate changes in group membership and network topology. Simulation results show that the multicast tree has low cost, and data delivered over it experiences moderately low latency.
Therapeutic strategies in Parkinson's disease: what we have learned from animal models (2014)

Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by a loss of dopaminergic neurons in the substantia nigra, as well as in other brain areas. The currently available dopamine replacement therapy provides merely symptomatic benefit and is ineffective because habituation and side effects arise relatively quickly. Studying the genetic forms of PD in animal models provides novel insight that allows targeting of specific aspects of this heterogenic disease more specifically. Among others, two important cellular deficits are associated with PD; these deficits relate to (1) synaptic transmission and vesicle trafficking, and (2) mitochondrial function, relating respectively to the dominant and recessive mutations in PD-causing genes. With increased knowledge of PD, the possibility of identifying an efficient, long-lasting treatment is becoming more conceivable, but this can only be done with an increased knowledge of the specific affected cellular mechanisms. This review discusses how discoveries in animal models of PD have clarified the therapeutic potential of pathways disrupted in PD, with a specific focus on synaptic transmission, vesicle trafficking, and mitochondrial function.
Continuous Gas‐Phase Hydroformylation of a Highly Diluted Technical C4 Feed using Supported Ionic Liquid Phase Catalysts (2011)

Abstract The concept of supported ionic liquid phase (SILP) catalysis has been established in recent years by our group and others. Its application in continuous catalytic gas‐phase processes provides a very attractive way to bridge the gap between homogeneous and heterogeneous catalysis. In this contribution, we extend SILP hydroformylation catalysis to reactions with a highly diluted, technical C4 feed containing 1.5 % 1‐butene, 28.5 % 2‐butenes, and 70 % of inert n ‐butane. To obtain the desired product, n ‐pentanal, the Rh‐biphephos catalyst system was immobilized in the SILP system to allow for consecutive isomerization/hydroformylation activity. The resulting SILP catalyst material converted up to 81 % of the reactive butenes, with a residence time of 155 s in the reactor. An n ‐pentanal selectivity greater than 92 % was realized for more than 500 h time‐on‐stream in the continuous gas‐phase reaction. Post‐reaction NMR studies revealed no significant loss of the phosphite ligand through ligand oxidation during the reaction.
Contrast-enhanced CT in pelvic trauma: correlation between fractures classification and associated lesions. (2014)

Poster: ECR 2014 / C-1956 / Contrast-enhanced CT in pelvic trauma: correlation between fractures classification and associated lesions. by: A. Bartoloni1, L. Cristiano1, R. Persechino1, R. D'Amico2, G. Fioroni3, L. Pugliese4, F. Caporilli Razza1, C. Cantone4, G. Argento5; 1Rome/IT, 2Roma (RM)/IT, 3Scandriglia/IT, 4Roma/IT, 5Ronciglione VT/IT
Ex vivo expansion of megakaryocytic cells. (2000)

The use of platelet transfusion to ensure the recovery of thrombopoiesis in patients constitutes high-cost support. The identification and cloning of recombinant human thrombopoietin (TPO) and the development of efficient methods of purification of hematopoietic stem cells and progenitor cells have ameliorated the development of strategies of ex vivo expansion of megakaryocyte (MK) progenitor cells and mature MKs. Synergistic combinations of cytokines including TPO, interleukin (IL)-1, IL-3, IL-11, stem cell factor, and FLT-3 ligand induce the ex vivo expansion of colony-forming unit-MK progenitors and MKs from cytokine-mobilized peripheral blood cells, bone marrow, and cord blood CD34+ cells. Depending on the various culture conditions, i.e., combinations of growth factors, initial concentration of CD34+, serum or serum-free cultures, and/or oxygen tensions, the expansion-fold of MKs and their progenitor cells vary greatly. The clinical applications of the reinfusion of ex vivo-generated MK cells have been investigated successfully in cancer patients following high-dose chemotherapy. This review reports the latest information concerning ex vivo expansion of MKs and the current status of clinical trials.
Adhesion in Biological Systems (2012)

No AccessAdhesion and Adhesives TechnologyJun 2012Adhesion in Biological SystemsAlphonsus V. PociusAlphonsus V. Pociushttps://doi.org/10.3139/9783446431775.012SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2012Pages: 325-336Print ISBN: 978-3-446-42748-8eISBN: 978-3-446-43177-5 Copyright & Permissions© 2012 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Hormonal regulation of the adrenocortical cell (1980)

Monolayer cultures of bovine and human adrenocortical cells have been used to study regulation of growth and function. Homogeneous bovine adrenocortical cells exhibit a finite life span of approximately 60 generations in culture. Full maintenance of differentiated function (steroid hormone synthesis) requires an inducer such as ACTH and antioxidizing conditions. Full induction of differentiated function occurs only when cellular hypertrophy is stimulated by growth factors such as fibroblast growth factor and serum. ACTH and other agents that increase cellular cAMP inhibit replication but do not block growth factor-induced cellular hypertrophy. ACTH and growth factors together result in a hypertrophied, hyperfunctional cell. Replication ensues only when desensitization to the growth inhibitory effects of ACTH occurs. Cultures of the definitive and fetal zones of the human fetal adrenal cortex synthesize the steroids characteristic of the two zones in vivo. ACTH stimulates production of dehydroepiandrosterone (DHA), the major steroid product of the fetal zone, and of cortisol, the characteristic steroid product of the definitive zone. Prolonged ACTH treatment of fetal zone cultures results in a preferential increase in cortisol production so that the pattern of steroid synthesis becomes that of the definitive zone. The preferential increase in cortisol production by fetal Zone cultures results from induction of 3 beta-hydroxysteroid dehydrogenase, delta 4,5 isomerase activity, which is limiting in fetal zone cells. ACTH thus causes a phenotypic change in fetal zone cells to that of definitive zone cells. In both bovine and human adrenocortical cells, the principal effect of ACTH is to induce full expression of differentiated function. This occurs only under conditions where growth substances and nutrients permit full amplification.
[Benign development of Purtscher's syndromes]. (1984)

3 cas de retinopathie traumatique. Les sequelles fonctionnelles sont bien mises en evidence au test d'Amsler ou a la perimetrie statique meridienne. Ces troubles subjectifs posent un probleme medico-legal
Body surface mapping guided VT localization: user interface considerations (2002)

A user interface is presented to use multichannel ECG recordings to guide a physician during the ablation of ventricular tachycardia (VT). A database of paced body surface QRS integral maps is used for a fast and accurate first approximation of the site of origin of the VT. A multichannel pace mapping procedure is then used to further enhance the accuracy until radiofrequency ablation can be performed.
On Attempted Oxidative Cyclisation of IsomericN,N'-Diphenylphenylenediamines and TheirN,N'-Dimethyl Derivatives by Palladium(II) Acetate and Uv Light (2000)

Abstract The cyclisation of N,N'-diphenyl-o-, m- and p-phenylenediamines and their N,N'-dimethyl derivatives by palladium(II) acetate and UV light separately led to both bis-cyclisation, furnishing indolocarbazoles, and mono-cyclisations with cleavage as well as retention of one substituent, producing substituted carbazoles.
Circuits for a P.C.M. Transmitter and ReceiverBell Laboratories Memorandum, June 1, 1944. (2009)

<P>Circuits are described for a P.C.M. transmitter and receiver. The transmitter operates on the principle of counting in the binary system the number of quanta of charge required to nullify the sampled voltage.</P>
A single visit, reattachment of fractured crown fragment (2010)

"Minimal intervention with maximum dentistry" The immediate restorative technique resolving the acute problem of traumatic tooth fracture with pulpal involvement-An immediate fracture fragment reattachment using pre-fabricated fiber post with dual cure cement-A challenging, conservative, aesthetics, rehabilitating, functionally, and economically viable single visit procedure.
Intramolekularer Ladungsübergang bei Dialkylamino‐nitrobiphenylen (1971)

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2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) or Diethylstilbestrol (DES) Cause Similar Hematopoietic Hypocellularity and Hepatocellular Changes in Murine Fetal Liver, but Differentially Affect Gene Expression (2007)

TCDD and DES have immunotoxic effects, including selective diminution of T lymphocyte progenitors in the fetal liver. The histologic presentation of fetal liver after exposure to either chemical has not been described. Similarly, limited information exists regarding mechanisms by which TCDD or DES may alter fetal hematopoiesis. Treatment of pregnant C57BL/6 mice with either 10 micro g/kg/day TCDD or 48 micro g/kg/day DES on gestation days (gd) 14 and 16 led to increased fetal liver weight on gd 18. Moderate anisocytosis and anisokaryosis with increased cytoplasmic and nuclear sizes, and increased cytoplasmic basophilia were present within hepatocytes after TCDD or DES. Both chemicals also decreased the presence of hematopoietic cells, however megakaryocyte numbers were unaffected. In contrast to these similar outcomes, real time quantitative PCR using a preliminary panel of 4 genes suggested that the chemicals act through different gene targets. TCDD increased c-jun gene expression in fetal liver, and decreased p53 without alteration in bcl-2 expression, indicating possible pro-proliferative and antiapoptotic effects. DES decreased c-jun and bcl-2, without altering p53, suggesting a shift away from proliferation. Both agents decreased PKCalpha expression, which may suggest shared decreased phosphorylation of substrates required for normal cell cycle progression.
Facial pain and multiple cranial palsies in a patient with skin cancer (2011)

Perineural tumor invasion is a rare complication of cancer though well-reported phenomenon among patients with head and neck cancer. Multiple cranial neuropathies as an initial symptom of recurrent neoplasm have been reported in few studies. The latest study by Leach et al. [1] reported multiple cranial nerve involvement in 67% (4 out of 6 patients) of the patient in comparison to 21% (13 out of 62 patients) found in a study of Mendenhall et al. [2]. Facial pain, progressive weakness of the facial nerve and involvement of fifth cranial nerve were the symptoms most often referred by the patients in previous studies [1–5]. The similarities of the symptoms with Bell’s palsy, trigeminal neuralgia or facial pain of uncertain etiology can lead to misdiagnosis and postpone treatment of highly morbid tumors. Here we describe a patient with multiple cranial neuropathies due to perineural spread of squamous cell carcinoma (SCC), whom the diagnostic procedure establishment of a final diagnosis was a long and challenging process because of repetitive non-diagnostic biopsies and negative magnetic resonance imaging (MRI).
Reinforced Control and Operation of DFIG-Based Wind-Power-Generation System Under Unbalanced Grid Voltage Conditions (2009)

This paper proposes an enhanced control and operation of a doubly fed induction generator (DFIG) based wind power generation system under unbalanced grid voltage conditions. System behaviors of grid-side and rotor-side converters (GSCs and RSCs) are described. The RSC is controlled to eliminate the electromagnetic torque oscillation at double the grid frequency. Meanwhile, three selective control targets for the GSC, i.e., reducing the pulsations in the total active or reactive power, or unbalanced current outputs from the overall system, are identified and analyzed during voltage imbalance. A new current-control scheme is presented for the GSC and RSC without involving the decomposing of positive and negative sequence currents. The controller consists of a proportional (P) regulator and a resonant (R) one tuned at the grid frequency, which is implemented in the stator stationary reference frame. Finally, simulation studies are carried out on a 1.5-MW wind-turbine-driven DFIG system. The validity of the presented current controller and the feasibility of the proposed control targets are all confirmed by the simulated results.
Stability of Imipenem and Cilastatin Sodium in Total Parenteral Nutrient Solution (1990)

The chemical stability and compatibility of imipenem-cilastatin sodium (Primaxin) in two different total parenteral nutrient (TPN) solutions was determined. TPN solutions consisted of 4.25% and 5% amino acids with 25% and 35% dextrose, respectively. Imipenem-cilastatin sodium was constituted with 10 ml of sterile water and admixed with 90 ml of TPN solution for a final concentration of 5 mg/ml of each drug. The final solutions were assayed at times 0 (immediately after admixture), 15 min, 30 min, 1, 4, 8, and 24 hr by a stability-indicating high-performance liquid chromatographic assay. Concurrently, test TPN solutions were monitored for pH changes, color changes, and precipitate formation. The potential effect of imipenem-cilastatin sodium on the stability of amino acids and other TPN additives was not evaluated. Imipenem and cilastatin sodium was stable (greater than or equal to 90% recovered) in each TPN solution at 15 min. A significant (greater than or equal to 10%) and steady decrease of imipenem recovery occurred at subsequent sampling times. Cilastatin appeared more stable than imipenem in both TPN solutions. A physical color change from colorless to dark orange appeared in each TPN solution over the 24-hr study period. Imipenem-cilastatin sodium is stable for 15 min in the TPN solutions studied; however, until the stability of the amino acids can be determined, the antibiotic should be administered through a separate line or Y-site while the TPN infusion is interrupted.