gebhart/patrepeval huggingface dataset:
Expression of VEGF in Peripheral Serum Is a Possible Prognostic Factor in Bone-Regeneration via Masquelet-Technique—A Pilot Study (2021)

Two-step Masquelet-technique established a new procedure in the treatment of osseous defects, addressing prerequisites postulated by the "diamond concept". Increase in blood perfusion and growth factors are enhanced by the "Masquelet-membrane". To describe this, we measured serum levels of Vascular Endothelial Growth Factor (VEGF) of patients with atrophic non-unions of long bones undergoing Masquelet-technique. From over 500 non-union patients undergoing Masquelet-technique with prospective follow-up we randomly selected 30 patients. 23 were included, 7 lost to follow-up or excluded because of incomplete data. Serum was drawn at specified intervals before and after surgery. Patients were followed for at least 6 months after step 2. Classification into both groups was performed according to radiological results and clinical outcome 6 months after step 2. Concentration of VEGF in patients' serum was performed via ELISA. 14 achieved osseous consolidation (responder group), 9 cases did not (non-responder). Responders showed a significant increase of serum-VEGF in the first and second week when compared to the preoperative values of step 1. Non-responders showed a significant increase of VEGF in the second week after Steps 1 and 2. Comparison of groups showed significantly higher increase of serum-VEGF week2 after step 1 and preoperative to step 2 for responders. Results show one possibility of illustrating therapeutic progress by monitoring growth factors and possibly allowing prognostic conclusions thereof. This might lead to a more targeted treatment protocol.
Sequential Catalysis: A Metathesis/Dihydroxylation Sequence. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
On centralized and distributed frequency assignment in cognitive radio based frequency hopping cellular networks (2010)

Frequency Assignment is an important approach to mitigate multi-cell interference in cellular systems. In this paper, we consider frequency hopping as one possible frequency assignment approach. In particular we focus our attention on cognitive radio cellular systems as one of the very promising future access technologies, taking IEEE 802.22 as an example. While the optimal frequency assignment for such a system is conceptually straightforward as well as computationally complex, we demonstrate that usage of distributed methods leads to a significant loss of assignment efficiency. In addition, we suggest means of mitigating this adverse effect.
Archival HTTP redirection retrieval policies (2013)

When retrieving archived copies of web resources (mementos) from web archives, the original resource's URI-R is typically used as the lookup key in the web archive. This is straightforward until the resource on the live web issues a redirect: R ->R`. Then it is not clear if R or R` should be used as the lookup key to the web archive. In this paper, we report on a quantitative study to evaluate a set of policies to help the client discover the correct memento when faced with redirection. We studied the stability of 10,000 resources and found that 48% of the sample URIs tested were not stable, with respect to their status and redirection location. 27% of the resources were not perfectly reliable in terms of the number of mementos of successful responses over the total number of mementos, and 2% had a reliability score of less than 0.5. We tested two retrieval policies. The first policy covered the resources which currently issue redirects and successfully resolved 17 out of 77 URIs that did not have mementos of the original URI, but did of the resource that was being redirected to. The second policy covered archived copies with HTTP redirection and helped the client in 58% of the cases tested to discover the nearest memento to the requested datetime.
Pro-inflammatory diet is associated with a high number of cardiovascular events and ultra-processed foods consumption in patients in secondary care (2020)

A more pro-inflammatory diet is associated with a greater chance of having 2 and ≥ 3 cardiovascular events and cardiometabolic risk factors and were more likely to consume processed, ultra-processed and culinary ingredients compared to those with a more anti-inflammatory diet.
Terpene Cyclases and Prenyltransferases: Structures and Mechanisms of Action (2020)

Terpenes and isoprenoids are the most diverse small organic molecules on Earth. Here, we obtained the structures of sesquisabinene and santalene synthases from Santalum album L. in the presence or absence of substrate, substrate-like, or product-like molecules for a total of eight structures. All proteins crystallized in an “open”, noncatalytic conformation and, in the case of the FPP structure, three Mg2+ (MgABC) were bound in the active site region. We found that one of these Mg2+ (MgB), involved in pocket closure to the catalytically active conformation, interacted with a single inner-sphere amino acid, a bidentate diphosphate, and a facial arrangement of three water molecules, H2O-a,b,c: fac-[Mg(H2O)3XPP(Asn/Asp)]. Paradoxically, the same arrangement of ligands is found in closed-form, catalytically active “head-to-tail” prenyltransferases, such as farnesyl diphosphate synthase (FPPS), leading to the proposal that in these proteins, pocket closure is due to interaction with outer-sphere ligands (typically, two Asps) with H2O-a,b. We also discovered an extensive H-bond network that is present in related cyclases and prenyltransferases: the D-motif. This motif is centered around the totally conserved outer-sphere Asp that is bonded via H2O-c to MgB and comprises five amino acids, including a very highly conserved residue in the cyclases, an Arg, and a highly conserved residue in the αHT proteins, a Gln, and we propose that this motif may be involved in catalysis per se. Finally, using bioinformatics and mutagenesis, we show that many of the most highly conserved residues in these and other cyclases are outside the active site region and are in the noncatalytic β-domain, reflecting their evolutionary origin from βγ domain proteins, while a highly conserved α-domain Arg forms a salt bridge with a Glu that serves to stabilize the catalytically active αβ-domain structure.
Statistical modelling of the indoor radio channel - an acoustic analogy (2003)

Many models exist for the prediction of the wideband characteristics of the indoor radio channel. Techniques range from simple empirical models, to complex site-specific algorithms making use of ray-tracing or finite difference methods. The simpler models offer little guidance to the designer of practical systems, while the more complex approaches generally require a level of knowledge of the physical characteristics of the building that is at best time consuming and at worst, impossible, to obtain. This paper proposes an intermediate approach to the modelling of the indoor, wideband, radio channel, following a physical-statistical approach initially inspired by methods employed in acoustic modelling.
Complex Macromolecular Architectures Based on n-Hexyl Isocyanate and ϵ-Caprolactone Using Titanium-Mediated Coordination Polymerization (2008)

Well-defined diblock copolymers {PS-b-P(ϵ-CL)} and triblock terpolymers {PS-b-PI-b-P(ϵ-CL), PI-b-PS-b-P(ϵ-CL)} of polystyrene, PS, poly(ϵ-caprolactone), P(ϵ-CL), and polyisoprene, PI, were synthesized using CpTiCl2(OP) (P = PS, PS-b-PI, or PI-b-PS) as macroinitiator. Graft copolymers having polybutadiene, PBd, backbone and poly(n-hexyl isocyanate), PHIC, or P(ϵ-CL) branches {PBd-g-PHIC and PBd-g-P(ϵ-CL)} as well as block−graft terpolymers {PS-b-(PI-g-PHIC), PS-b-[PI-g-P(ϵ-CL)]} were also synthesized by performing hydroboration/oxidation reactions on the polydiene backbone and by transforming the introduced hydroxyl groups to initiation sites by reaction with CpTiCl3. Finally, PS(PHIC)2 and PS[P(ϵ-CL)]2 3-miktoarm star copolymers were synthesized using a heterofunctional initiator bearing one initiation site for atom transfer radical polymerization and two for titanium-mediated coordination polymerization. All intermediates and final products were characterized by size exclusion chromatography, equipped with refractive index and light scattering detectors, membrane osmometry, and 1H NMR spectroscopy.
Real-Time Detection and Control of Microchannel Resonance Frequency in Acoustic Trapping Systems by Monitoring Amplifier Supply Currents (2021)

The utilization of bulk acoustic waves from a piezoelectric transducer for selective particle trapping under flow in a microchannel is limited by the high sensitivity of the resonance frequency to tolerances in device geometry, drift during trapping, and variations in the local flow or sample conditions in each channel. This is addressed by detecting the resonance condition based on the impedance minimum obtained by monitoring the amplitude of the stimulation voltage across the piezo transducer and utilizing real-time feedback to control the stimulation frequency. However, this requires an overlap in the frequency bandwidth of the detection and the stimulation system and is also limited by the decline in the acoustic trapping power when the stimulation and resonance frequency measurement are conducted simultaneously. Instead, we present a novel circuit implementation for on-chip real-time resonance frequency measurement and feedback control based on monitoring the current drawn from the amplifier used to stimulate the piezo transducer, since the need for high measurement sensitivity in this mode does not lower the power available for stimulation of the transducer. The enhanced level of control of acoustic trapping utilizing this current mode is validated for various localized channel perturbations, including drift, wash steps, and buffer swaps, as well as for selective sperm cell trapping from a heterogeneous sample that includes lysed epithelial cells.
Prediction of image propagation quality through the atmosphere:the dependence of atmospheric modulation transfer function on weather (1990)

Using the atmospheric modulation contrast function area (MCFA) as a single-valued numerical criterion for image quality propagated through the atmosphere, a statistical study of atmospheric imaging data has led to the determination of regression coefficients with which to quantitatively predict, at visible and near-infrared wavelengths, effects of wind speed, air temperature, and relative humidity on image quality propagated through the atmosphere as functions of wavelength and of spatial frequency. Utilization of this procedure is quite simple: one merely plugs expected values for wind speed, air temperature, and relative humidity into the regression coefficient expression for the MCFA. The larger the expected MCFA, the better the expected image quality. Models are presented for desert and nondesert atmospheres. Preliminary experimentation indicates that the accuracy of the models is quite good and that the quality of image propagation through the atmosphere can be described as a simple function of basic macroscale meteorological dependences previously unknown. These fundamental meteorological parameters are part of weather forecasts measured worldwide, are simple and inexpensive to measure, and also can be used to determine the overall atmospheric modulation contrast function as a function of spatial frequency and meteorological conditions. An important advantage of this new approach is its simplicity as well as its accuracy.
SAR triangle CW LFM signal formation and imaging (2014)

Synthetic Aperture Radar (SAR) with triangle Linear Frequency Modulated (LFM) Continuous Wave (CW) is considered. Algorithms for signal formation and image reconstruction of a moving target are suggested. Three-dimensional (3-D) SAR geometry of the target presented as an assembly of point scatterers is analytically described. Mathematical expressions for distance vector determination defined from SAR to each point scatterer are derived. SAR signal model based on a triangle linear frequency modulated continuous wave emitted signal, 3-D geometry and reflectivity function of the target is derived. Image reconstruction procedure based on Fourier transform for range compression and azimuth compression is applied. SAR imaging algorithm of a moving target is suggested. Numerical experiment is carried out.
Identification of a Retinoic Acid Receptor α Subtype Specific Agonist (1996)

ADVERTISEMENT RETURN TO ISSUELetterNEXTIdentification of a Retinoic Acid Receptor α Subtype Specific AgonistMin Teng, Tien T. Duong, Elliott S. Klein, Mary E. Pino, and Roshantha A. S. ChandraratnaView Author Information Retinoid Research, Departments of Chemistry and Biology, Allergan Incorporated, Irvine, California 92713-9534 Cite this: J. Med. Chem. 1996, 39, 16, 3035–3038Publication Date (Web):August 2, 1996Publication History Received15 May 1996Published online2 August 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jm9603532https://doi.org/10.1021/jm9603532rapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views533Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Agonists,Amides,Receptors,Screening assays,Selectivity Get e-Alerts
SGS1, a Homologue of the Bloom's and Werner's Syndrome Genes, Is Required for Maintenance of Genome Stability in Saccharomyces cerevisiae (1996)

The Saccharomyces cerevisiae SGS1 gene is homologous to Escherichia coli RecQ and the human BLM and WRN proteins that are defective in the cancer-prone disorder Bloom's syndrome and the premature aging disorder Werner's syndrome, respectively. While recQ mutants are deficient in conjugational recombination and DNA repair, Bloom's syndrome cell lines show hyperrecombination. Bloom's and Werner's syndrome cell lines both exhibit chromosomal instability, sgs1 delta strains show mitotic hyperrecombination, as do Bloom's cells. This was manifested as an increase in the frequency of interchromosomal homologous recombination, intrachromosomal excision recombination, and ectopic recombination. Hyperrecombination was partially independent of both RAD52 and RAD1. Meiotic recombination was not increased in sgs1 delta mutants, although meiosis I chromosome missegregation has been shown to be elevated sgs1 delta suppresses the slow growth of a top3 delta strain lacking topoisomerase III. Although there was an increase in subtelomeric Y' instability in sgs1 delta strains due to hyperrecombination, no evidence was found for an increase in the instability of terminal telomeric sequences in a top3 delta or a sgs1 delta strain. This contrasts with the telomere maintenance defects of Werner's patients. We conclude that the SGS1 gene product is involved in the maintenance of genome stability in S. cerevisiae.
IgE Binding to Pepsin-Digested Food Extracts (2005)

Pepsin-digested food extracts are a convenient tool to identify patients with IgE antibodies against potentially dangerous stable allergens, in particular for those foods where the relevant stable allergens have not yet been identified. This can increase the clinical prognostic value of food allergy serology.
Influence of Swirl and Tumble on Economy and Emissions of Multi Valve SI Engines (1992)

&lt;div class="htmlview paragraph"&gt;The future challenges for spark ignition (SI) engines to drastically reduce the exhaust emissions and fuel consumption while still maintaining high specific power output will be addressed. In order to further improve stoichiometric engine concepts with three-way-catalyst, reduced cold start and warm-up fuel enrichment as well as a higher EGR tolerance gain fundamental importance. Both objectives will be met if the combustion system of the engine features a high lean burn capability.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Due to less freedom of multi-valve engines in combustion chamber shapes, resulting in minor squish effects, the intake generated charge motion plays the dominant role to assure an efficient combustion of even highly diluted mixtures. Basing on results of experimental combustion and flow test bench studies, the performance of swirl and tumble intake systems for multi-valve SI engines will be compared and evaluated. Special attention will be paid on the tumble formation process and measurement of the tumble intensities. A newly designed stationary tumble measurement method for development purposes will be demonstrated which enables to determine the tumble intensities.&lt;/div&gt;
Studies on the Alkaloids of Securinega virosa Pax. et Hoffm. IV.1 The Preferred Conformations of Allosecurinine (Phyllochrysine) and Dihydrosecurinine (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on the Alkaloids of Securinega virosa Pax. et Hoffm. IV.1 The Preferred Conformations of Allosecurinine (Phyllochrysine) and DihydrosecurinineT. Nakano, T. H. Yang, and S. TeraoCite this: J. Org. Chem. 1964, 29, 11, 3441–3443Publication Date (Print):November 1, 1964Publication History Published online1 May 2002Published inissue 1 November 1964https://pubs.acs.org/doi/10.1021/jo01034a528https://doi.org/10.1021/jo01034a528research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Decongestion With Acetazolamide in Acute Decompensated Heart Failure Across the Spectrum of Left Ventricular Ejection Fraction: A Prespecified Analysis From the ADVOR Trial (2022)

gov; Unique identifier: NCT03505788.
Common 82-nucleotide sequence unique to brain RNA. (1982)

Several randomly selected cDNA clones made from rat brain polyA+RNA have unusual properties. Although the cDNA inserts are 500-1,250 base pairs long, they hybridize to a 160-nucleotide RNA species that is present in brain but not in liver or kidney. Nucleotide sequence studies of two of the clones and hybridization studies show that a common 82-nucleotide sequence is responsible for the hybridization. The same sequence is located in the second intron of a rat growth hormone gene. These studies suggest that signals called "ID sequences" may be carried in the introns of genes and prescribe their tissue-specific expression.
Germacranolides from Carpesium divaricatum: Some New Data on Cytotoxic and Anti-Inflammatory Activity (2021)

<i>Carpesium divaricatum</i> Sieb. & Zucc., a traditional medicinal plant used as an inflammation-relieving remedy, is a rich source of terpenoids. At least 40 germacrane-type sesquiterpene lactones, representatives of four different structural groups, were isolated from the plant. Cytotoxicity against cancer cells in vitro is the most frequently described biological activity of the compounds. However, little is known about the selectivity of the cytotoxic effect. The anti-inflammatory activity of the germacranolides is also poorly documented. The objective of the present study was to assess the cytotoxic activity of selected <i>C. divaricatum</i> germacranolides-derivatives of 4,5,8,9-tetrahydroxy-3-oxo-germacran-6,12-olide towards cancer and normal cell lines (including cells of different p53 status). Moreover, to assess the anti-inflammatory effect of the compounds, the release of four proinflammatory cytokines/chemokines (IL-1β, IL-8, TNF-α and CCL2) by lipopolysaccharide-stimulated human neutrophils was measured by ELISA. The investigated sesquiterpene lactones demonstrated nonselective activity towards prostate cancer (Du145 and PC3) and normal prostate epithelial cells (PNT2) as well as against melanoma cells (A375 and HTB140) and keratinocytes (HaCaT). Cytotoxic activity against osteosarcoma cells was independent of their p53 status. In sub-cytotoxic concentrations (0.5-2.5 µM) the studied compounds significantly decreased cytokine/chemokine release by lipopolysaccharide-stimulated human leukocytes.
A Novel CMOS Imager with 2-Dimensional Binarization and Edge Detection for Highly Integrated Imaging Systems (2006)

The proposed CMOS imager successfully embeds an advanced local threshold algorithm to simultaneously achieve the 2-dimensional operations of binarization and edge detection. Both functions provide a lot of widely spread applications for real-time imaging systems. A 64 /spl times/ 64 pixel array imager is implemented in the TSMC 0.35 /spl mu/m 2P4M technology. Each pixel has the size of 10 /spl mu/m /spl times/ 10 /spl mu/m with a fill factor of 36.1%. The test chip occupies 1.80 mm /spl times/ 1.63 mm and consumes 15 mW from a 3.3 V power supply.
Factors Affecting Suppression of Endogenous Thyrotropin Secretion by Thyroxine Treatment: Retrospective Analysis in Athyreotic and Goitrous Patients* (1987)

TSH suppression requires daily doses of T4 between 2.5 and 2.9 micrograms/kg BW in athyreotic patients and between 1.9 and 2.3 micrograms/kg BW in goitrous patients, with appropriate adjustments in relation to the age of the patient; Assessment of the adequacy of treatment should not be carried out before 6 months after the institution of therapy.
A Study of Machining Characteristics of YG8 in High Speed Grinding (2011)

The machining characteristics of cemented carbide YG8 under high speed grinding conditions are reported in this paper. The experimental investigation focused on the grinding force, surface roughness and surface characteristics influenced by various wheel speeds, feed rates and depths of cut. Surface roughness was slightly improved by increasing of wheel speed, and the increase in h max generated bigger grinding force and decreased specific energy, which could be explained by material removal mode and SEM micrographs of surface. The results revealed that high machining efficiency was achieved and relatively good surface roughness was obtained simultaneously.