gebhart/patrepeval huggingface dataset:
Integrative genomic analysis by interoperation of bioinformatics tools in GenomeSpace (2016)

Complex biomedical analyses require the use of multiple software tools in concert and remain challenging for much of the biomedical research community. We introduce GenomeSpace (http://www.genomespace.org), a cloud-based, cooperative community resource that currently supports the streamlined interaction of 20 bioinformatics tools and data resources. To facilitate integrative analysis by non-programmers, it offers a growing set of 'recipes', short workflows to guide investigators through high-utility analysis tasks.
Neoadjuvant Clinical Trial With Sorafenib for Patients With Stage II or Higher Renal Cell Carcinoma (2020)

The multitargeted tyrosine kinase inhibitor sorafenib is used for the treatment of advanced-stage renal cell carcinoma. However, the safety and efficacy of this agent have yet to be evaluated in the preoperative period, where there may be potential advantages including tumor downstaging. This prospective trial evaluates the safety and feasibility of sorafenib in the preoperative setting.
Respiratory Syncytial Virus Genotypes, Host Immune Profiles, and Disease Severity in Young Children Hospitalized With Bronchiolitis (2017)

RSV A infections were more frequent than RSV B, and displayed greater variability. GA5 infections were associated with enhanced disease severity and distinct host immune responses.
On the Morphology of a Discotic Liquid Crystalline Charge Transfer Complex (2012)

Discotic liquid crystalline (DLC) charge transfer (CT) complexes, which combine visible light absorption with rapid charge transfer characteristics within the CT complex, can have a great potential for photovoltaic applications when they can be made to self-assemble in a bulk heterojunction arrangement with separate channels for electron and hole conduction. However, the morphology of some liquid crystalline CT complexes has been under debate for many years. In particular, the liquid crystalline CT complex built from the electron acceptor 2,4,7-trinitro-9-fluorenone (TNF) and discotic molecules has been reported to have the TNF "sandwiched" either between the discotic molecules within the same column or between the columns within the aliphatic tails of the discotic molecules. We present a detailed structural study of the prototypic 1:1 mixture of the discotic 2,3,6,7,10,11-hexakis(hexyloxy)triphenylene (HAT6) and TNF. Nuclear magnetic resonance (NMR) line widths and cross-polarization rates are consistent with the picosecond time scale anisotropic thermal motions of the HAT6 and TNF molecules previously observed. By computational integration of Rietveld refinement analyses of neutron diffraction patterns with density experiments and short-range structural constraints from heteronuclear 2D NMR, we determine that the TNF molecules are vertically oriented between HAT6 columns. The data provide the insight that a morphology of separate hole conducting channels of HAT6 molecules can be realized in the liquid crystalline CT complex.
Evaluation of the insulin application system Autopen 24® (2005)

In patients with insulin therapy, a simple to use, reliable and safe insulin application device is a prerequisite to achieve good glucose control, and for reducing and avoiding progression of secondary complications. Modern injection pen systems provide the patient with a high degree of flexibility and quality of life. However, the integration of further and appropriate therapeutic aids into a device can make a positive contribution to compliance and therapy satisfaction. In this multicentre, open, randomised, three-month, cross-over study, the new insulin application device Autopen 24® (designed for Sanofi-Aventis insulin cartridges) was evaluated in comparison to the established OptiPen® Pro device with regard to clinical efficacy (HbA1c, frequency of severe hypoglycaemic episodes) and patients' preference and acceptance in 40 patients (20 women, 20 men; 20 type 1, 20 type 2; age [mean±SD] 49.3±15.1 years; BMI 29.0±5.0 kg/m2). No differences were seen regarding HbA1c and hypoglycaemic episodes between the treatment groups. The Autopen 24 showed a high level of acceptance by patients in comparison to OptiPen Pro and was preferred by older patients with type 2 diabetes. In conclusion, Autopen 24 is a suitable alternative to other injection devices in patients with diabetes mellitus treated with Sanofi-Aventis insulin products. Copyright © 2005 John Wiley & Sons, Ltd.
Can childhood viral infection protect from type 1 diabetes? (2009)

While many candidate type 1 diabetes (T1D) susceptibility genes have been identified, evidence suggests that environmental stimuli, such as viral infections, may also be involved in T1D pathogenesis. However, how viral infections may prevent or trigger the diabetogenic process remains unclear. In this issue of the JCI, Filippi et al. show that infection of NOD mice with Coxsackie virus B3 or lymphocytic choriomeningitis virus, neither of which directly destroys insulin-secreting pancreatic beta cells, triggers the activation of two distinct immunoregulatory mechanisms, involving both the innate and adaptive immune system, that protect against the development of T1D in these animals (see the related article beginning on page 1515).
Syntheses of the tedanolides (2008)

This Highlight covers the synthetic contributions leading to the syntheses of tedanolide and 13-deoxytedanolide or the corresponding macrolactones, respectively. Additionally, the first SAR data for 13-deoxytedanolide (published by Fusetani) are presented.
exo,exo-Bis(isodicyclopentadienyl)titanium and -zirconium Dichlorides: Conformational Characterization of the Homogeneous Ziegler Catalyst Precursors in Solution (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTexo,exo-Bis(isodicyclopentadienyl)titanium and -zirconium Dichlorides: Conformational Characterization of the Homogeneous Ziegler Catalyst Precursors in SolutionCornelia Fritze, Markus Knickmeier, Gerhard Erker, Florence Zaegel, Bernard Gautheron, Philippe Meunier, and Leo A. PaquetteCite this: Organometallics 1995, 14, 11, 5446–5449Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/om00011a073https://doi.org/10.1021/om00011a073research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel function for the p38‐MK2 signaling pathway in circulating CD1c+ (BDCA‐1+) myeloid dendritic cells from healthy donors and advanced cancer patients; inhibition of p38 enhances IL‐12 whilst suppressing IL‐10 (2013)

There is growing interest in myeloid (my) dendritic cells (DC) as an alternative to monocyte-derived DC (moDC) for immunotherapy. However, in contrast to moDC, little is known regarding the effect of malignancy on the function, abundance or use of intracellular signaling pathways in myDC. Understanding the molecular detail of circulating myDC is therefore important for future use in advanced cancer. Advanced cancer patients had similar numbers of circulating myDC to cancer-free patients and healthy individuals, and secreted similar levels of IL-1β, IL-6, IL-10, IL-12 and IL-23. However, myDC from some patients failed to secrete the Th1-cytokine IL-12. Surprisingly, inhibiting p38 (p38i) signaling (using BIRB0796 or SB203580) markedly increased IL-12 secretion by myDC. This is in complete contrast to what is established for moDC where inhibiting p38 ablates IL-12. Interestingly, this was specific to IL-12, since IL-10 was suppressed by p38i in both DC types. The opposing effect of p38i on IL-12 was evident at the transcriptional level and in both DC types was mediated through the p38-MK2 pathway but did not involve differential phosphorylation of the distal Rsk kinase. Importantly, where patient myDC did not secrete IL-12 (or after treatment with suppressive melanoma lysate), p38i restored IL-12 to normal levels. In contrast to p38, inhibiting the other MAPK pathways had similar consequences in both DC types. We show for the first time the differential use of a major intracellular signaling pathway by myDC. Importantly, there are sufficient circulating myDC in advanced cancer patients to consider development of adoptive immunotherapy.
Computer simulation of successively solutional fractionation of macromolecules (1972)

Abstract The successive solution fractionation (SSF) ( i.e. , the successive solvent extraction of coacervate) was simulated by using an electronic computer. A polymer having the most probable distribution of number average degree of polymerization, X 0 n = 150, and weight average degree of polymerization, X 0 w = 300, was hypothetically fractionated, on the basis of the generalized FLORY‐HUGGINS‐FUJISHIRO theory in which the concentration dependence of the polymer/solvent interaction parameter, expressed as p, was taken into account. As p is increased the composition of the fraction with a larger degree of polymerization (X), obtained by SSF, decreased, while the smaller X region remained almost constant. The composition of the fraction in the region of the smaller X is much smaller than that obtained from successive precipitation fractionation (SPF). The fractionation data ( X w and the amount of the fraction) were analyzed according to the treatment of SCHULZ and of KAMIDE et al . The results revealed that the first one is preferable to the second one in the case of SSF. The broadness of the molecular weight distribution in the fraction markedly decreased with decrease in the initial concentration of polymer, v 0 p , if v 0 p was higher than 0.1%. An asymtotic, limiting value for X w / X n of an extremely small fraction of polymer, separated by SSF, was appreciably larger than that from SPF, but the corresponding value for the standard deviation was zero. The molecular weight distribution of the fractions becomes narrower as their amount is smaller. This behaviour is in contrast to the case of SPF. In SSF, a decreasing in the relative amount of each fraction, besides that of an initial concentration, effectively enables fractions of narrow distribution to be obtained.
Efficient single image non-uniformity correction algorithm (2010)

This paper introduces a new way to correct the non-uniformity (NU) in uncooled infrared-type images. The main defect of these uncooled images is the lack of a column (resp. line) time-dependent cross-calibration, resulting in a strong column (resp. line) and time dependent noise. This problem can be considered as a 1D flicker of the columns inside each frame. Thus, classic movie deflickering algorithms can be adapted, to equalize the columns (resp. the lines). The proposed method therefore applies to the series formed by the columns of an infrared image a movie deflickering algorithm. The obtained single image method works on static images, and therefore requires no registration, no camera motion compensation, and no closed aperture sensor equalization. Thus, the method has only one camera dependent parameter, and is landscape independent. This simple method will be compared to a state of the art total variation single image correction on raw real and simulated images. The method is real time, requiring only two operations per pixel. It involves no test-pattern calibration and produces no "ghost artifacts".
Signaling pathways involved in cardiac energy metabolism (2016)

Various signaling pathways coordinate energy metabolism and contractile function in the heart. Myocardial uptake of long-chain fatty acids largely occurs by facilitated diffusion, involving the membrane-associated protein, CD36. Glucose uptake, the rate-limiting step in glucose utilization, is mediated predominantly by the glucose transporter protein, GLUT4. Insulin and contraction-mediated AMPK signaling each are implicated in tightly regulating these myocardial 'gate-keepers' of energy balance, that is, CD36 and GLUT4. The insulin and AMPK signaling cascades are complex and their cross-talk is only beginning to be understood. Moreover, transcriptional regulation of the CD36 and GLUT4 is significantly understudied. This review focuses on recent advances on the role of these signaling pathways and transcription factors involved in the regulation of CD36 and GLUT4.
Theory and simulation of nonrelativistic elliptic-beam formation with one-dimensional Child-Langmuir flow characteristics (2005)

A theory of nonrelativistic, laminar, elliptic-beam formation is presented. The beam is shown to have the one-dimensional Child-Langmuir flow form. An analytic expression for the electrostatic potential outside the beam is derived. Equipotentials corresponding to electrode surfaces are computed numerically. The effectiveness of the electric field formed by the electrodes in focusing and preserving the elliptic, 1D Child-Langmuir flow beam is verified via 3D ray-tracing simulations.
Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins (2021)

ADP-ribosylation is a reversible post-translational modification where an ADP-ribose moiety is covalently attached to target proteins by ADP-ribosyltransferases (ARTs). Although best known for its nuclear roles, ADP-ribosylation is increasingly recognized as a key regulatory strategy across cellular compartments. ADP-ribosylation of mitochondrial proteins has been widely reported, but the exact nature of mitochondrial ART enzymes is debated. We have identified neuralized-like protein 4 (NEURL4) as a mitochondrial ART enzyme and show that most ART activity associated with mitochondria is lost in the absence of NEURL4. The NEURL4-dependent ADP-ribosylome in mitochondrial extracts from HeLa cells includes numerous mitochondrial proteins previously shown to be ADP-ribosylated. In particular, we show that NEURL4 is required for the regulation of mtDNA integrity via poly-ADP-ribosylation of mtLIG3, the rate-limiting enzyme for base excision repair (BER). Collectively, our studies reveal that NEURL4 acts as the main mitochondrial ART enzyme under physiological conditions and provide novel insights in the regulation of mitochondria homeostasis through ADP-ribosylation.
Isolation of RNA Aptamers Targeting HER-2-overexpressing Breast Cancer Cells Using Cell-SELEX (2009)

Ligand molecules that can recognize and interact with cancer cell surface marker proteins with high affinity and specificity should greatly aid the development of novel cancer diagnostics and therapeutics. HER-2/ErbB2/Neu (HER-2), a member of the epidermal growth factor receptor family, is specifically overexpressed on the surface of breast cancer cells and serves as both a useful biomarker and a therapeutic target for breast cancer. In this study, we aimed to isolate RNA aptamers that specifically bind to a HER-2-overexpressing human breast cancer cell line, SK-BR-3, using Cell-SELEX strategy. The selected aptamers showed strong affinity to SK-BR-3, but not to MDAMB- 231, a HER-2-underexpressing breast cancer cell line. In addition, we confirmed the specific targeting of HER-2 receptor by aptamers using an unrelated mouse cell line overexpressing human HER-2 receptor. The HER-2-targeting RNA aptamers could become a useful reagent for the development of breast cancer diagnostics and therapeutics.
Patterns of Practice in Intensity-modulated Radiation Therapy and Image-guided Radiation Therapy for Prostate Cancer in Japan (2011)

The results of the survey identified current patterns in the treatment planning and delivery processes of external-beam radiation therapy for prostate cancer in Japan.
End-to-end QoS solution for real-time multimedia application (2007)

To deliver real-time multimedia application end-to-end QoS,Differentiated Service(DiffServ) has two key components-packet marking(classification) and service policy.This paper discusses tools to implement end-to-end QoS for real-time multimedia application.It also gives the analysis of key technologies of DiffServ classification and service policy for Quality of Service(QoS).Then the detail approaches and practical steps of Differentiated Service are proposed to provide the end-to-end Quality of Service for real-time multimedia application.The approaches are implemented and evaluated using Cisco router and switch architecture.The results show that network resources are better allocated and control for real-time multimedia application.In the end,the drawbacks and future of the Differentiated Service are set forth.
<title>Pulse Code Modulation Of CO<formula><inf><roman>2</roman></inf></formula> Transversely Excited Atmospheric (TEA) Laser Rangefinder</title> (1980)

The CO, TEA Laser Rangefinder can be utilized for both ranging and information transfer by modulating the tail of the CO2 TEA laser pulse. This multifunctional capability for the CO, laser rangefinder is achieved by pulse code modulation with an electro-optic modulator. A CdTe crystal Pockels Cell used in a double-pass configiration has produced a train of optical pulses 100 nanoseconds wide at 5 MHz repetition rate.
On reverse engineering an object-oriented code into UML class diagrams incorporating extensible mechanisms (2008)

Reverse engineering is the key idea for reconstruction of any existing system. In this paper, we propose an algorithm to reverse engineer an object-oriented code into Unified Modeling Language (UML) class diagram. Our algorithm is very general in nature and can be applied to any object-oriented code irrespective of the object-oriented programming language. In our paper we consider an object-oriented pseudocode similar to C++ to implement our algorithm. Some of the researchers have dealt in the past the problem of reverse engineering an object-oriented code to UML class diagrams. However, none of these researchers have treated all the constructs available in UML class diagrams. Unlike the previously done work on reverse engineering into UML, our algorithm generates rules for a complete set of constructs available in UML class diagrams. It includes classes, relationships, objects, attributes, operations, inheritance, associations, interfaces &amp; other extensible mechanisms also. This algorithm can be viewed as a solution to reverse engineer any available object-oriented software. An application for the implementation of above said rules using C++ code is also included in the paper. We thoroughly compare our work with the similar type of earlier work in this area and uncover the deficiencies in these previous available works. Moreover our motive in this paper is to prepare rules to reverse engineer C++ code into UML class diagrams and not to generate any tools.
Configuration Cache Management for Coarse-Grained Reconfigurable Architecture with Multi-Array (2012)

Coarse-Grained Reconfigurable Architectures (CGRAs) can achieve both high performance and flexibility, and CGRAs with multi-array are used to meet the increasing performance requirement of multimedia applications. Meanwhile, the context size also becomes quite large, so many CGRAs use a configuration cache to reduce reconfiguration overhead. However, with high power consumption, configuration cache management is still a challenge. This paper first analyzes context features of media algorithms, and introduces the base hardware architecture. Then a configuration cache management technique is proposed to implement H.264 video decoding on the base architecture. It includes a novel configuration cache structure and a configuration cache replacement algorithm based on Context Sequence Prefetching & Priority (CSPP). The experimental results show that the proposed approach can drastically improve system performance and reduce power consumption. The average configuration cache hit rate of CSPP is 96.83%, the speedup ranges from 64% to 109%, and our approach can support H.264 1080p@30fps decoding at a 200MHz working frequency.
ChemInform Abstract: Molecular Studies of Model Surfaces of Metals from Single Crystals to Nanoparticles under Catalytic Reaction Conditions. Evolution from Prenatal and Postmortem Studies of Catalysts (2010)

Abstract Review: 107 refs.
AFRICAN AND AFRICAN AMERICAN BUSINESS HISTORY Black Business and Economic Power. Edited by ALUSINE JALLOH and TOYIN FALOLA. Rochester NY: University of Rochester Press, 2002. Pp. xii+628. $67.95; £50 (ISBN 1-58046-114-x). (2004)

AFRICAN AND AFRICAN AMERICAN BUSINESS HISTORY Black Business and Economic Power. Edited by ALUSINE JALLOH and TOYIN FALOLA. Rochester NY: University of Rochester Press, 2002. Pp. xii+628. $67.95; £50 (ISBN 1-58046-114-x). - Volume 45 Issue 1
REVIEWS Vocation de l'École. By EMERYLÉON. Lyons: Les Cahiers Libres. 1966. 144 pp. (1967)

REVIEWS Get access Vocation de l'École. By LÉON EMERY. Lyons: Les Cahiers Libres. 1966. 144 pp. ANTHONY LEVI ANTHONY LEVI OXFORD Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume XXI, Issue 4, October 1967, Pages 384–385, https://doi.org/10.1093/fs/XXI.4.384 Published: 01 October 1967
The cold‐shock response — a hot topic (1994)

The cold-shock response of Escherichia coli describes a specific pattern of gene expression in response to abrupt shifts to lower temperatures. This pattern includes the induction of cold-shock proteins, synthesis of proteins involved in transcription and translation, and repression of heat-shock proteins. The identified cold-shock proteins are involved in various cellular functions from supercoiling of DNA to initiation of translation. The major cold-shock protein, CspA, has high sequence similarity with three other E. coli proteins--CspB, CspC, and CspD. Using translational lacZ fusions, cspB was found to be cold-shock inducible at the level of transcription like cspA, while cspC and cspD were not. The Csp proteins, which share sequence similarity with other prokaryotic proteins and with the 'cold-shock domain' of eukaryotic Y-box proteins, may have a function in activating transcription or unwinding or masking RNA molecules. Because the cold-shock response can also be induced by the addition of certain inhibitors of translation, it has been proposed that the state of the ribosome is the physiological sensor for the induction. In addition to E. coli, cold-shock proteins have also been found in other prokaryotic and eukaryotic organisms.
Electrical Properties of Boron Monophosphide Epitaxially Grown on Silicon Substrate (1974)

By varying the deposition temperatures and the flow rates of reactant gases, n- and p-type BP are epitaxially grown on Si (100) substrates using B2H6-PH3-H2 system. nBP- p +Si and pBP-n +Si hetero-junctions and p-mBP · n +Si homojunctions are made. Yellowish color of the BP might be due to the broadening of the transmissivity in the short-wave-length region through the BP forbidden energy gap.