gebhart/patrepeval huggingface dataset:
ADAMTS-12 Metalloprotease Is Necessary for Normal Inflammatory Response (2012)

ADAMTSs (a disintegrin and metalloprotease with thrombospondin domains) are a family of enzymes with both proteolytic and protein interaction functions, which have been implicated in distinct pathologies. In this work, we have investigated the putative role of ADAMTS-12 in inflammation by using a mouse model deficient in this metalloprotease. Control and mutant mice were subjected to different experimental conditions to induce colitis, endotoxic sepsis, and pancreatitis. We have observed that Adamts12-deficient mice exhibit more severe inflammation and a delayed recovery from these challenges compared with their wild-type littermates. These changes are accompanied by an increase in inflammatory markers including several cytokines, as assessed by microarray expression analysis and proteomic-based approaches. Interestingly, the clinical symptoms observed in Adamts12-deficient mice are also concomitant with an elevation in the number of neutrophils in affected tissues. Finally, isolation and in vitro culture of human neutrophils demonstrate that the presence of ADAMTS-12 induces neutrophil apoptosis. On the basis of these results, we propose that ADAMTS-12 is implicated in the inflammatory response by modulating normal neutrophil apoptosis.
128 SHADES OF RED: Objective Remote Assessment of Radiation Dermatitis by Augmented Digital Skin Imaging (2017)

The purpose of our investigation was to develop a novel and state of the art digital skin imaging method capable for remote monitoring and objective assessment of Radiation Induced Dermatitis (RID). Therefore, radiation therapy related side effects were assessed by medical experts according to Common Terminology Criteria for Adverse Events (CTCAE) grade of severity in 20 female breast cancer patients in a clinical trial over the treatment time frame of 25-28 radiation cycles, 50.0-50.4 Gy each. Furthermore the intensity of developed skin erythema was documented by using conventional spectrophotometry plus digital skin imaging. Thereby we could derive the Standardized Erythema Value (SEV), a novel objective parameter, which in contrast to single parametric L* and a* delivers a long dynamic measurement range for analyzing RID from bright to very dark skin tones. Methodical superiority of the SEV could be proven over spectrophotometer measurements in terms of a higher sensitivity and by enabling signal intensity mapping in analyzed skin images. Our thereupon-derived patent enables novel objective dermatologic eHealth applications in a broad range of medical and industrial use by opening likewise the window for augmented dermatology. The first of its kind system is now already further developed in form of the medical device product Scarletred<sup>®</sup>Vision. It is available on the market for primary usage in clinical trials and in medical routine.
Anomaly Detection using Context Dependent Optical Flow (2018)

Anomaly detection is a major task in crowd management through video surveillance. It refers to the events which are deviated from normal events. We have introduced an unsupervised method to detect motion anomaly in surveillance video. In this work we have considered only optical flow as feature. First, for each frame we compute magnitude of optical flow of motion using flownet2 [10]. Then, mean of magnitude of flow due to regular normal motion (given in training data) is computed at each pixel where such motion exists in the training video frames. Our strategy is to compare the motion under consideration against this mean flow magnitude, and we expect that the anomalous motion would differ significantly from normal motion. An autoencoder type network is trained to detect this anomaly. Training data patch is constructed by Interleaving the columns of mean optical flow patch and the corresponding flow patch from each frame. This interleaving is done to incorporate context dependency. The autoencoder is trained to minimize mean-square reconstruction error between input column wise interleaved patch and output (i.e., reconstructed patch) of the autoencoder. During testing, a patch is declared anomalous if the reconstruction error is high compared to the training error. Experiments have been carried out on UCSD and UMN dataset and are compared with other methods. Our method gives comparable results with other state-of-the-art methods.
Differential Diagnosis of Juvenile Idiopathic Arthritis (2017)

Juvenile idiopathic arthritis (JIA) is a broad spectrum of disease defined by the presence of arthritis of unknown etiology, lasting more than six weeks duration, and occurring in children less than 16 years of age. JIA encompasses several disease categories, each with distinct clinical manifestations, laboratory findings, genetic backgrounds, and pathogenesis. JIA is classified into seven subtypes by the International League of Associations for Rheumatology: systemic, oligoarticular, polyarticular with and without rheumatoid factor, enthesitis-related arthritis, psoriatic arthritis, and undifferentiated arthritis. Diagnosis of the precise subtype is an important requirement for management and research. JIA is a common chronic rheumatic disease in children and is an important cause of acute and chronic disability. Arthritis or arthritis-like symptoms may be present in many other conditions. Therefore, it is important to consider differential diagnoses for JIA that include infections, other connective tissue diseases, and malignancies. Leukemia and septic arthritis are the most important diseases that can be mistaken for JIA. The aim of this review is to provide a summary of the subtypes and differential diagnoses of JIA.
What Practitioners Need to Know…About Lognormality (1992)

Why should we care about logarithms? In the days prior to pocket calculators (long before my time), logarithms were useful for performing complicated computations. Financial analysts would multiply large numbers by summing their logarithms, and they would divide them by subtracting their logarithms. For example, given a base of 4, we can multiply 16 times 8 by raising the number 4 to the 3.5 power, which is the sum of the logarithms 2 and 1.5. Of course, you might argue that it would have been easier to multiply large numbers directly than to raise a base to a fractional power. In the olden days, however, an analyst would use a slide rule, which is a ruler with a sliding central strip marked with logarithmic scales.
Study of the structural properties of a-SiCN: H films using hexamethyldisilazane for high-quality silicon surface passivation (2006)

We have analyzed the structural and electrical properties of a-SiCN:H films prepared by HWCVD using HMDS and related these to the deposition parameters and its passivating qualities for the purpose of optimizing these films for passivation layers of silicon solar cells. We found that deposition pressure, HMDS flow rate and H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> flow rate had significant effects on the structural properties, chemical composition ratio and bond densities, and influenced passivation effect of a-SiCN:H films. This study indicates that hydrogen concentration derived from Si-H bond in a-SiCN:H films plays an important role in passivating qualities, while the nitrogen content and Si-N bond density are significant parameters that determine the diffusivity of hydrogen in the films. The dependence of anneal characteristics of a-SiCN:H films on nitrogen content was observed. The optimization of the composition ratio and H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> concentration of a-SiCN:H films will lead to the high quality silicon surface passivation
Asymptotic analysis to blow-up points for the porous medium equation with a weighted non-local source (2009)

This article deals with the porous medium equation with a more complicated source term, subject to the homogeneous Dirichlet condition, where is a ball with radius R, m > 1 and the non-negative constants satisfying . We investigate how the three factors (the non-local source , the local source and the weight function a(x)) influence the asymptotic behaviour of the solutions. It is proved that (i) when p < 1, the non-local source plays a dominating role, i.e. the blow-up set of the system is the whole domain B R , a , where . (ii) When p > m, this system presents single blow-up patterns. In other words, the local term dominates the non-local term in the blow-up profile. Moreover, the blow-up rate estimate is established with more precise coefficients determined.
Low-affinity CAR T cells exhibit reduced trogocytosis, preventing fratricide and antigen-negative tumor escape while preserving anti-tumor activity (2021)

ABSTRACT Chimeric antigen receptor (CAR) T cells using the high-affinity CD19 binding domain FMC63 are an effective treatment for patients with relapsed and aggressive B cell lymphoma. However, antigen loss and poor CAR T cell persistence remain common causes for relapse in these patients. Using primary patient samples, we now show that FMC63-based CAR T cells confer rapid antigen loss in all major tumor types currently approved for treatment with CD19 CAR T cells via trogocytosis, the stripping of antigen from tumor cells by CAR T cells. We show that CAR T cell-mediated trogocytosis can be dramatically reduced across a wide range of B cell malignancies by replacing FMC63 with a low affinity CD19 antibody. This reduction in trogocytosis does not alter the direct anti-tumor activity of CD19 CAR T cells but prevents the emergence of antigen-negative tumor cells and significantly increases CAR T cell viability by reducing fratricide of CD19 CAR T cells following trogocytosis. TEASER A reduction in CAR affinity does not affect tumor killing but prolongs T cell persistence and prevents antigen-negative tumor escape.
Design of comb-like profiled fiber for efficient pulse compression based on stationary rescaled-pulse propagation (2005)

We propose the design procedure of a comb-like profiled fiber compressor based on stationary rescaled-pulse propagation, and demonstrate optical pulse compression of a 7-ps pulse train to 375-fs through the designed compressor with only four steps.
False Localizing Signs in Upper Cervical Spinal Cord Compression (1996)

Proprioceptive loss, paresthesias, and atrophy of the hands can occur with disorders afflicting the upper cervical spinal cord. The diagnosis might be erroneous, because compression in this region might produce signs and symptoms that seem to originate in the lower cervical cord. This article reviews the clinical presentation and radiographic data of a consecutive series of 11 patients who presented between 1992 and 1994 with an extradural lesion above the C4 level. Each patient had a characteristic syndrome of finger and hand dysesthesia, hand atrophy, and occipital or cervical pain. These complaints usually preceded the development of spasticity and gait disturbance. Initial diagnoses included brachial plexopathy, shoulder dysfunction, viral syndrome, and cervical spondylosis at a lower segment. Cervical spondylosis or a herniated disc was the most common pathogenesis. The most commonly involved level was C3-C4. Nine patients underwent a surgical procedure; eight showed significant postoperative improvement (mean time of follow-up examination, 9.7 mo; follow-up range, 1-24 mo). One patient was lost to follow-up. Although the pathophysiology of these findings is unknown, theories include anterior spinal artery ischemia, venous obstruction, and differential decussation of the forelimb and hindlimb fibers of the corticospinal tract. Recognition of this syndrome might prevent inappropriate operative intervention in patients with coexisting pathological conditions of the lower cervical spinal cord.
Anticoking Coatings for High Temperature Petrochemical Reactors (1999)

Coke deposition is a major problem for several refinery and petrochemical processes, among which steam cracking for ethylene production. Decreasing coking rates will reduce decoking frequency and will also decrease heat transfer degradation. For these processes, a means of reducing coking phenomena is the application of anticoking coatings on the reactor walls. For this purpose a methodology was developed under a CEC Brite-Euram project with steam cracking as the main application. A first selection of the coatings and their techniques of deposition was performed according to their composition (non catalytic compounds), their resistance to carburization and oxidation and also according to the nature of the substrate. The feasibility of coating deposition was studied for small diameter furnace tubes and the techniques were perfected in particular with respect to the physicochemical characterization of the coatings and their resistance during thermal cycling and coking-decoking cycles. For the thermal cycling and the coking evaluation, industrial conditions were reproduced as closely as possible. For coking tests, a microreactor with complete mixing of the gas phase was developed for temperatures up to 950°C. The coking behavior of the coated samples was compared with conventional refractory alloys: reduction of the coking rate by a factor of 3 was measured with the most promising coating. This work was completed by the kinetic modelling of coking on uncoated materials.
Using Bender’s Decomposition for Optimal Power Control and Routing in Multihop D2D Cellular Systems (2019)

In this paper, multihop device-to-device (D2D) communications for cell coverage extension are studied. An in-band underlay D2D mode is considered, and the aim is to satisfy the signal-to-noise-ratio requirements for pre-allocated resource blocks (RBs) on the downlink connections, the signal-to-interference-plus-noise-ratio requirements on pre-allocated RBs for every D2D sidelink connection, and a maximum allowable interference at the base station receiver on all uplink RBs. Power control and routing are performed to minimize the expended user equipment energy in the system while meeting these requirements. An optimization problem is formulated that turns out to be a mixed-integer nonlinear program, which is solved using the generalized Benders decomposition (GBD). The GBD breaks down the formulation into a master sub-problem, an auxiliary sub-problem, and a feasibility sub-problem. In this paper, we focus on finding efficient solution methods for the relaxed version of the master sub-problem that is responsible for generating lower bounds on the optimal objective function. Also, an efficient solution technique for the feasibility sub-problem is proposed. Furthermore, a benchmark disjoint scheme for the same problem is proposed, which performs routing and power control separately. The simulations are conducted to compare the performance of both schemes, which show the superiority of joint routing and power control scheme.
Multiphoton superresolution imaging using lateral-axial tomography and single-pixel spatial-frequency projections (Conference Presentation) (2019)

The majority of optical super-resolution imaging methods have been developed for thin or transparent biological samples, where the effects of scattering are minimized. Moreover, most of these techniques are based on the manipulation of fluorescent probes, or other molecular real-energy states. Multiphoton spatial frequency modulated imaging (MP-SPIFI) provides a pathway for super-resolving fine structures through multiple scattering lengths by making use of a modulated line focus and nonlinear excitation, and is applicable to both fluorescence and harmonic generation imaging. The technique works by projecting a set of 1D spatial frequencies onto the object, and utilizing the multiphoton interaction to drive harmonics of the spatial frequencies. The result is that an n-photon interaction yields frequency support of nearly 2n beyond the lens NA in the lateral x-dimension, along the line focus. However, the axial resolution of the object is limited in the conventional way by how tightly the line is focused. Here, we improve axial resolution by employing a limited-angle diffraction tomography, where the illumination is rotated in the x-z plane relative to the sample. The set of angular measurements are coherently combined in spatial-frequency space. Using a priori information about the location of each measurement in this kx-kz space greatly enhances the signal-to-noise ratio of the reconstructed object. We expect the method to be a useful way to improve resolution in deep-tissue imaging, or with any sample that exhibits strong scattering.
Efficacy of SCRI-CAR19x22 T cell product in B-ALL and persistence of anti-CD22 activity. (2020)

3035 Background: Loss of CD19 expression is a major cause of limited durable B-ALL remission following CD19 CAR T cells, which might be overcome by utilization of dual CD19xCD22 CAR T cell targeting. Methods: A Phase I trial (NCT03330691) of SCRI-CAR19x22 was developed using dual transduction of lentiviral vectors encoding for either a CD19- or CD22-specific CAR T cell construct, both with 4-1BB co-stimulation. Manufacturing was performed in a closed G-Rex system with IL-7, IL-15 and IL-21. After lymphodepletion, CAR T cells were infused at 1 or 3 X 10 6 CAR T cells/kg dose levels. Leukemic response and CAR T cell persistence were evaluated by flow cytometry. Results: Products were successfully manufactured in all 28 enrolled subjects with 7.92 average days in culture (range of 7-11 days) and consisted of an average CD8:CD4 ratio of 3.09 (range 0.19 to 8.9). The cellular product CAR composition was 29% CD19, 31% CD22 and 39% CD19 and CD22 targeting. 13 subjects had prior exposure to CD19 or CD22 targeting therapies with diverse expression of CD19 and CD22 on the leukemic blasts. No dose limiting toxicities occurred in the 27 infused subjects. The recommended phase 2 dose is 3 x 10 6 CAR+ cells/kg. CRS was present in 80% of subjects, with 85% of CRS being grade 2 or less, and a peak grade of 3 (n = 3). Mild neurotoxicity occurred in 38%, with a single grade 3 event. 84.6% obtained a CR, of which 95% were MRD negative. Of the 4 subjects who did not achieved a CR, 2 had a pre-existing CD19 negative population and one had previously received CAR T cells and rejected SCRI-CAR19x22. There have been 4 relapses with varying CD19 and CD22 expression as follows: 1 CD19-CD22-, 1 CD19+CD22+, and 2 CD19-CD22+. The in vivo engraftment of CAR T cells peaked most frequently between day +7 and +14 and was predominated by the CD19 CAR+ T cells. Conclusions: We demonstrate manufacturing feasibility and safety of SCRI-CAR19x22. While initial efficacy is demonstrated, CD22 activity is poor due to limited expansion of the CD22 CAR-containing components and subjects with pre-existing CD19 negative leukemia fared poorly. Development of a revised CD22 CAR that exhibits a reduction tonic signaling is underway, with plans to explore the new construct in the context of a dual-targeting CD19xCD22 CAR T cell product. Clinical trial information: NCT03330691 .
The Constraint Consensus Method for Finding Approximately Feasible Points in Nonlinear Programs (2004)

This paper develops a method for moving quickly and cheaply from an arbitrary initial point at an extreme distance from the feasible region to a point that is relatively near the feasible region of a nonlinearly constrained model. The method is a variant of a projection algorithm that is shown to be robust, even in the presence of nonconvex constraints and infeasibility. Empirical results are presented.
Bronchial Thermoplasty for Severe Asthma (2013)

Bronchial thermoplasty (BT) is a new therapeutic modality for the ­treatment of severe asthmatics refractory to optimal medical therapy. Individuals with uncontrolled symptoms despite treatment with high dose inhaled corticosteroids and long-acting bronchilator therapy are eligible for this procedure. BT uses radiofrequency energy to reduce the excess airway smooth muscles that can occur in asthma. Since airway smooth muscle is implicated in hyperreactivity and bronchoconstriction, BT can be adjunctive to anti-inflammatory therapy. Thermal treatment is delivered distal to mainstem bronchi to visible airways between 3 and 10 mm in diameter, excluding the right middle lobe. Treatments occur in three separate sessions with careful monitoring before and after the procedure, as the most frequent complication is exacerbation of asthma symptoms. Clinical trials have demonstrated an acceptable safety profile while improving asthma quality of life scores, symptoms, and health care utilization, resulting in FDA approval of this procedure in 2010. More recent evidence demonstrates persistence of beneficial effects up to 2 years after the procedure. Proper patient selection, optimization of confounding conditions, and ongoing asthma management are key factors in improving outcomes and minimizing adverse respiratory events. As experience with the procedure increases, better characterization of asthmatics that may benefit from this procedure will become available.
General Study on the Dimming Control of the LED Lighting Device (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Weight gain and obesity after liver transplantation (2005)

Excessive weight gain is common after liver transplantation and frequently leads to obesity. This has been attributed to immunosuppression. The aim of the present study was to assess the extent of weight gain and the risk factors for weight gain after liver transplantation. Height and estimated dry weight were collected prospectively in consecutive adult liver-transplant patients, transplanted between January 1996 and October 2001. A total of 597 patients (45% female, median age of 50 years; range 16-73) was studied. Eighty-six percentage was transplanted for chronic liver disease. The median weight gain at 1 and 3 years was 5.1 and 9.5 kg above dry weight pretransplant. By 1 and 3 years, 24% and 31% had become obese (defined as a body mass index (BMI) >30 kg/m(2)). There was no significant difference in weight gain between the sexes, those who were obese before transplantation or those who received corticosteroids for >3 months. Weight gain was significantly greater (P < 0.05) in patients aged >50 years and those transplanted for chronic liver disease compared with fulminant liver failure. A pretransplant BMI >30 was a strong indicator that the patient would still have a BMI >30 at 3 years. There was no effect of the type of immunosuppression on weight gain. Obesity is common in the liver transplant population, but it seems to be unrelated to any specific immunosuppressive drug. The greatest weight gain occurs after the first 6 months and intervention with dietary advice at this point could be implemented to minimize the long-term morbidity and mortality risks associated with obesity.