gebhart/patrepeval huggingface dataset:
Variation in individual responses to the cytotoxicity of cigarette smoke. (1980)

There is increasing evidence that elastase may mediate pulmonary damage in emphysema and also that the release of intracellular elastase by cigarette smoke is necessarily associated with cell death. We report consistent and significant variation in response of lymphocytes from different individuals to the cytotoxic effect of cigarette smoke condensate in vitro. This variation which occurred at levels of cigarette smoke likely to be encountered in vivo and which was independent of the age, sex, or smoking habits of the subjects, may be relevant in determining the risk of developing emphysema amongst smokers.
THE BEST ORNAMENT最佳配饰之Q＆A (2005)

站在首饰台前思前想后，就是拿不定主意的你；总觉得自己的首饰没别人漂亮的你；只要一戴首饰出门，就被别人评价为没品位的你；——千万不要误会自己天生与首饰无缘，事实上到目前为止，你只是还没学会如何挑选最适合自己的首饰的方法。读读下面的建议。相信，你一定会有所收获。
Power Analysis Attacks on ECC Randomized Automata (2007)

Power analysis can exploit the instantaneous power consumptions of Elliptic curve cryptography ECC) devices and retrieve secret keys. Many countermeasures have been proposed to make ECC implementations secure. One of the approaches is the randomized algorithms proposed by Oswald et al., which combine two scalar point multiplication algorithms and use random variables to decide which algorithm to follow at different stages of the computation. In this paper, we describe a power analysis attack that can break randomized automata proposed by Oswald et al. effectively, even with a small number of power traces.
Unique molecular characteristics and microglial origin of Kv1.3 channel–positive brain myeloid cells in Alzheimer’s disease (2021)

Kv1.3 potassium channels, expressed by proinflammatory central nervous system mononuclear phagocytes (CNS-MPs), are promising therapeutic targets for modulating neuroinflammation in Alzheimer's disease (AD). The molecular characteristics of Kv1.3-high CNS-MPs and their cellular origin from microglia or CNS-infiltrating monocytes are unclear. While Kv1.3 blockade reduces amyloid beta (Aβ) burden in mouse models, the downstream immune effects on molecular profiles of CNS-MPs remain unknown. We show that functional Kv1.3 channels are selectively expressed by a subset of CD11b<sup>+</sup>CD45<sup>+</sup> CNS-MPs acutely isolated from an Aβ mouse model (5xFAD) as well as fresh postmortem human AD brain. Transcriptomic profiling of purified CD11b<sup>+</sup>Kv1.3<sup>+</sup> CNS-MPs, CD11b<sup>+</sup>CD45<sup>int</sup> Kv1.3<sup>neg</sup> microglia, and peripheral monocytes from 5xFAD mice revealed that Kv1.3-high CNS-MPs highly express canonical microglial markers (<i>Tmem119</i>, <i>P2ry12</i>) and are distinct from peripheral Ly6c<sup>high</sup>/Ly6c<sup>low</sup> monocytes. Unlike homeostatic microglia, Kv1.3-high CNS-MPs express relatively lower levels of homeostatic genes, higher levels of <i>CD11c</i>, and increased levels of glutamatergic transcripts, potentially representing phagocytic uptake of neuronal elements. Using irradiation bone marrow CD45.1/CD45.2 chimerism in 5xFAD mice, we show that Kv1.3<sup>+</sup> CNS-MPs originate from microglia and not blood-derived monocytes. We show that Kv1.3 channels regulate membrane potential and early signaling events in microglia. Finally, in vivo blockade of Kv1.3 channels in 5xFAD mice by ShK-223 reduced Aβ burden, increased CD11c<sup>+</sup> CNS-MPs, and expression of phagocytic genes while suppressing proinflammatory genes (<i>IL1b</i>). Our results confirm the microglial origin and identify unique molecular features of Kv1.3-expressing CNS-MPs. In addition, we provide evidence for CNS immunomodulation by Kv1.3 blockers in AD mouse models resulting in a prophagocytic phenotype.
Time-Compression Multiplexing (TCM) of Three Broadcast-Quality TV Signals on a Satellite Transponder (1983)

We describe how Time-Compression Multiplexing (TCM) might enable the transmission of three National Television System Committee (NTSC) color TV signals through a satellite transponder of 36-MHz bandwidth. The input TV signals are processed such that three fields from each TV source are compressed into an ordinary field period. This is accomplished by sending one field as is but time compressed; the other two fields are sent as differential signals, also time compressed such that all three fit into a single field period. The resultant compressed waveforms are then time multiplexed between the three sources and have a combined baseband bandwidth of 7.52 MHz for an optimal case, or 8.4 MHz for a practical version. In either case, both the transmitter-multiplexer and the receiver-demultiplexer require only three field memories for (digital) signal processing. Performance is expected to be of network broadcast quality (i.e., weighted signal-to-noise ratio, s/n ≥ 56 dB) for the optimal case of 7.52-MHz baseband if 12-meter receive earth stations are employed in a system such as COMSTAR. The practical version, on the other hand, would yield an s/n ≈ 54 dB.
Hydration of Unsaturated Compounds. XI. Acrolein and Acrylic Acid1 (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydration of Unsaturated Compounds. XI. Acrolein and Acrylic Acid1D. Pressman and H. J. LucasCite this: J. Am. Chem. Soc. 1942, 64, 8, 1953–1957Publication Date (Print):August 1, 1942Publication History Published online1 May 2002Published inissue 1 August 1942https://doi.org/10.1021/ja01260a057RIGHTS & PERMISSIONSArticle Views449Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (507 KB) Get e-Alerts Get e-Alerts
<title>Two-dimensional and 3-D images of thick tissue using time-constrained times-of-flight and absorbance spectrophotometry</title> (1992)

Reconstructing deep-tissue images in real time using spectrophotometric data from optically diffusing thick tissues has been problematic. Continuous wave applications (e.g., pulse oximetry, regional cerebral saturation) ignore both the multiple paths traveled by the photons through the tissue and the effects of scattering, allowing scalar measurements but only under limited conditions; interferometry works poorly in thick, highly-scattering media; frequency- modulated approaches may not allow full deconvolution of scattering and absorbance; and pulsed-light techniques allow for preservation of information regarding the multiple paths taken by light through the tissue, but reconstruction is both computation intensive and limited by the relative surface area available for detection of photons. We have developed a picosecond times-of-flight and absorbance (TOFA) optical system, time-constrained to measure only photons with a narrow range of path lengths and arriving within a narrow angel of the emitter-detector axis. The delay until arrival of the earliest arriving photons is a function of both the scattering and absorbance of the tissues in a direct line between the emitter and detector, reducing the influence of surrounding tissues. Measurement using a variety of emitter and detector locations produces spatial information which can be analyzed in a standard 2-D grid, or subject to computer reconstruction to produce tomographic images representing 3-D structure. Using such a technique, we have been able to demonstrate the principles of tc-TOFA, detect and localize diffusive and/or absorptive objects suspended in highly scattering media (such as blood admixed with yeast), and perform simple 3-D reconstructions using phantom objects. We are now attempting to obtain images in vivo. Potential future applications include use as a research tool, and as a continuous, noninvasive, nondestructive monitor in diagnostic imaging, fetal monitoring, neurologic and cardiac assessment. The technique may lead to real-time optical imaging and quantitation of tissues oxygen delivery.
Mammalian retinal pigment epithelial cells in vitro respond to the neurokines ciliary neurotrophic factor and leukemia inhibitory factor (1997)

We examined whether primary cultures of rat retinal pigment epithelial (RPE) cells and RPE cells of an immortalized rat cell line, BPEI-1, would be responsive to the neurokines ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF), which are known to be potent trophic factors for neuronal cells. Primary RPE cell cultures were characterized by indirect immunofluorescence and exhibited positive immunoreactivity for RET-PE2, a monoclonal antibody that recognizes RPE cells, and for the intermediate filaments cytokeratin and vimentin. The survival of cultured RPE cells in serum-free defined medium in the presence of CNTF or LIF was investigated during a 0- to 5-day period. Both CNTF and LIF, at concentrations of 1-50 ng/mL (4-200 pM), markedly enhanced RPE cell survival. Bromodeoxyuridine labelling of RPE cells revealed an increased mitotic activity in cell cultures treated with either CNTF or LIF in comparison to untreated serum-free cultures. Increases in cell survival and proliferation after neurokine treatment were also observed with the BPEI-1 cell line. However, in comparison to the primary RPE cultures, LIF was more effective than CNTF in promoting survival of the cell line over a 5-day treatment period. These studies demonstrate that the neurokines CNTF and LIF are potent trophic factors for mammalian RPE cells in vitro and may serve as candidate therapeutic agents in degenerative conditions that affect the retina and RPE.
Water-Free Proton-Conducting Polysiloxanes:  A Study on the Effect of Heterocycle Structure (2007)

Proton-conducting, thermally and electrochemically stable, heterocycle-grafted polysiloxanes have been synthesized via hydrosilylation of vinyl or allyl functionalized weakly basic heterocyclic motifs with a polymethylhydrosiloxane precursor. The basicity of the amphoteric heterocycles was tuned by introducing electron-withdrawing groups, whose presence also produced a decrease in the polymers' glass transition temperature. The proton conductivity depended strongly on the Tg of the polymer matrix and the volume fraction of proton carriers, while the effect of reducing the pKa of the heterocycle was less pronounced. The resulting polymers showed the highest reported proton conductivities of up to 0.1 mS/cm at temperatures below 80 °C and up to 5 mS/cm at 180 °C when doped with trifluoroacetic acid.
On Chip Analysis of CNS Lymphoma in Cerebrospinal Fluid (2015)

Molecular profiling of central nervous system lymphomas in cerebrospinal fluid (CSF) samples can be challenging due to the paucicellular and limited nature of the samples. Presented herein is a microfluidic platform for complete CSF lymphoid cell analysis, including single cell capture in sub-nanoliter traps, and molecular and chemotherapeutic response profiling via on-chip imaging, all in less than one hour. The system can detect scant lymphoma cells and quantitate their kappa/lambda immunoglobulin light chain restriction patterns. The approach can be further customized for measurement of additional biomarkers, such as those for differential diagnosis of lymphoma subtypes or for prognosis, as well as for imaging exposure to experimental drugs.
Generation of directed circuits in a directed graph (1979)

A new matrix algorithm has been presented to generate all directed circuits in a given directed graph. The method is based on multiplication of the modified adjacency matrix of the graph by itself according to some modified rules of matrix multiplication.
Multi-echo Complex QSM+qBOLD (mcQQ) for Oxygen Extraction Fraction (OEF) mapping (2023)

Quantitative mapping of oxygen extraction fraction (OEF) is critical to evaluate brain tissue viability and function in neurologic disorders. An integrated model of QSM and qBOLD (QSM+qBOLD or QQ) has been developed to map OEF from a routine gradient echo MRI without the need for vascular challenges, and QQ inversion can be obtained using deep learning. This study proposes a multi-echo complex QQ (mcQQ) that improves fidelity to data noise characteristics using complex domain. The proposed mcQQ provided more accurate OEF in simulation and an improved sensitivity to OEF abnormalities in ischemic stroke patients, compared to the current QQ method.
Methods for quantifying the influences of pressure and temperature variation on metal hydride reaction rates measured under isochoric conditions (2013)

Analysis techniques for determining gas-solid reaction rates from gas sorption measurements obtained under non-constant pressure and temperature conditions often neglect temporal variations in these quantities. Depending on the materials in question, this can lead to significant variations in the measured reaction rates. In this work, we present two new analysis techniques for comparison between various kinetic models and isochoric gas measurement data obtained under varying temperature and pressure conditions in a high pressure Sievert system. We introduce the integral pressure dependence method and the temperature dependence factor as means of correcting for experimental variations, improving model-measurement fidelity, and quantifying the effect that such variations can have on measured reaction rates. We use measurements of hydrogen absorption in LaNi5 and TiCrMn to demonstrate the effect of each of these methods and show that their use can provide quantitative improvements in interpretation of kinetics measurements.
Influence of biofertilizers on stevioside content in Stevia rebaudiana grown in acidic soil condition (2010)

The present study was carried out to evaluate the influence of biofertilizers on stevioside content (Main active principle) in the leaves of Stevia rebaudiana grown in acidic soil condition. The six month field experiment study was revealed the combined application of three biofertilizers showed that the total yield of fresh biomass has been recorded an increase up to sixth month, being highest in the combined application of biofertilizers over that of their corresponding sole applications. The percent increase of bio-mass yield was recorded highest (22.14%) in the treatment when all the bio-fertilizers were applied together. Further the results envisaged the content of stevioside were recorded significantly higher (20.17 %) with the same treatments (T8) as compared to control by applied HPLC chromatogram. The chromatographic separations were carried out using a C18 column using the mobile phase consisting of methanol and water, and with UV detection at 210 nm. The limits of determination of stevioside were 4 μg/ml for the leaf extracts.
Spherical Parameterization Balancing Angle and Area Distortions (2016)

This work presents a novel framework for spherical mesh parameterization. An efficient angle-preserving spherical parameterization algorithm is introduced, which is based on dynamic Yamabe flow and the conformal welding method with solid theoretic foundation. An area-preserving spherical parameterization is also discussed, which is based on discrete optimal mass transport theory. Furthermore, a spherical parameterization algorithm, which is based on the polar decomposition method, balancing angle distortion and area distortion is presented. The algorithms are tested on 3D geometric data and the experiments demonstrate the efficiency and efficacy of the proposed methods.
Leafminer Control in Cantaloupes (1999)

Cantaloupe leaf damage from leafminer activity was minimal to non-existent when evaluated at 6 days after treatment (DAT) following each of the first four weekly application dates. At 13 DAT-4, the number of mined leaves increased tremendously over the previous observation date. The untreated cantaloupes showed an increase from 30.8 to 81.8 mined leaves compared to the previous week. Agri-mek and the alternation treatment of Trigard, Success7, and Agri-mek applied on cantaloupes showed the fewest number of mined leaves at about 22 mined leaves. Trigard and Success treated cantaloupes had increased number of mined leaves ranging from 44 to 56.8. Agri-mek and the alternation treatment consistently had the fewest number of mined leaves during the course of the test period. Trigard and Success treatments performed similarly and reduced the number of mined leaves relative to the untreated cantaloupes. Success at the higher rate appeared to be slightly more active by showing numerically fewer mined leaves than the lower rate of application. Success treated melons yielded nearly twice as much compared to the other treatments and the untreated. Success treated melons also offered a higher number of marketable fruit at better than 80% compared to about 60% for the other treatments. Less stickiness was observed on the Success treated cantaloupes. There appeared to be an effect from Success applications on whitefly to reduce the honeydew stickiness.
Effect of Salt Intake on Plasma and Tissue Levels of Endogenous Ouabain (1997)

Conference Abstract| February 01 1997 Effect of Salt Intake on Plasma and Tissue Levels of Endogenous Ouabain A Butt; A Butt 1Department of Chemical Pathology, Guy's and St Thomas' Hospital Trust, UMDS, London SE1 7EH Search for other works by this author on: This Site PubMed Google Scholar Y Semra; Y Semra 1Department of Chemical Pathology, Guy's and St Thomas' Hospital Trust, UMDS, London SE1 7EH Search for other works by this author on: This Site PubMed Google Scholar CS Ho; CS Ho 1Department of Chemical Pathology, Guy's and St Thomas' Hospital Trust, UMDS, London SE1 7EH*Department of Clinical Pathology Unit, Prince of Wales Hospital, Shatin, NT, Hong Kong Search for other works by this author on: This Site PubMed Google Scholar R Swaminathan R Swaminathan 1Department of Chemical Pathology, Guy's and St Thomas' Hospital Trust, UMDS, London SE1 7EH Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1997) 92 (s36): 8P. https://doi.org/10.1042/cs092008Pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation A Butt, Y Semra, CS Ho, R Swaminathan; Effect of Salt Intake on Plasma and Tissue Levels of Endogenous Ouabain. Clin Sci (Lond) 1 February 1997; 92 (s36): 8P. doi: https://doi.org/10.1042/cs092008Pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1997 The Biochemical Society and the Medical Research Society1997 Article PDF first page preview Close Modal You do not currently have access to this content.
Quantification of intraventricular blood clot in MR-guided focused ultrasound surgery (2015)

Intraventricular hemorrhage (IVH) affects nearly 15% of preterm infants. It can lead to ventricular dilation and cognitive impairment. To ablate IVH clots, MR-guided focused ultrasound surgery (MRgFUS) is investigated. This procedure requires accurate, fast and consistent quantification of ventricle and clot volumes. We developed a semi-autonomous segmentation (SAS) algorithm for measuring changes in the ventricle and clot volumes. Images are normalized, and then ventricle and clot masks are registered to the images. Voxels of the registered masks and voxels obtained by thresholding the normalized images are used as seed points for competitive region growing, which provides the final segmentation. The user selects the areas of interest for correspondence after thresholding and these selections are the final seeds for region growing. SAS was evaluated on an IVH porcine model. SAS was compared to ground truth manual segmentation (MS) for accuracy, efficiency, and consistency. Accuracy was determined by comparing clot and ventricle volumes produced by SAS and MS, and comparing contours by calculating 95% Hausdorff distances between the two labels. In Two-One-Sided Test, SAS and MS were found to be significantly equivalent (p &lt; 0.01). SAS on average was found to be 15 times faster than MS (p &lt; 0.01). Consistency was determined by repeated segmentation of the same image by both SAS and manual methods, SAS being significantly more consistent than MS (p &lt; 0.05). SAS is a viable method to quantify the IVH clot and the lateral brain ventricles and it is serving in a large-scale porcine study of MRgFUS treatment of IVH clot lysis.
3D Imaging for Mapping and Inspection Applications in Outdoor Environments (2011)

This chapter is aimed at introducing the fundamentals of three-dimensional (3D) imaging to scientists, students, and practitioners while also documenting recent developments in the ability to rapidly digitize real-world environments. We begin with a survey of popular 3D sensing options and list factors that challenge 3D imaging in outdoor environments. The survey guides the reader towards the choice of a 3D sensor for his or her application of interest. Then, we describe 3D data acquisition strategies and integration methodologies for multi-view range data from laser scanners, multi-view image data from cameras mounted on a mobile platform and multi-sensor localization based 3D mapping. We explain the steps involved in creating 3D models from raw sensor data for each of these data acquisition strategies. Finally, we document research results obtained in the Imaging, Robotics and Intelligent Systems Laboratory at the University of Tennessee, Knoxville from 3D imaging prototypes developed for automated pavement runway inspection and urban mapping.
ADAM22, A Kv1 Channel-Interacting Protein, Recruits Membrane-Associated Guanylate Kinases to Juxtaparanodes of Myelinated Axons (2010)

Clustered Kv1 K(+) channels regulate neuronal excitability at juxtaparanodes of myelinated axons, axon initial segments, and cerebellar basket cell terminals (BCTs). These channels are part of a larger protein complex that includes cell adhesion molecules and scaffolding proteins. To identify proteins that regulate assembly, clustering, and/or maintenance of axonal Kv1 channel protein complexes, we immunoprecipitated Kv1.2 alpha subunits, and then used mass spectrometry to identify interacting proteins. We found that a disintegrin and metalloproteinase 22 (ADAM22) is a component of the Kv1 channel complex and that ADAM22 coimmunoprecipitates Kv1.2 and the membrane-associated guanylate kinases (MAGUKs) PSD-93 and PSD-95. When coexpressed with MAGUKs in heterologous cells, ADAM22 and Kv1 channels are recruited into membrane surface clusters. However, coexpression of Kv1.2 with ADAM22 and MAGUKs does not alter channel properties. Among all the known Kv1 channel-interacting proteins, only ADAM22 is found at every site where Kv1 channels are clustered. Analysis of Caspr-null mice showed that, like other previously described juxtaparanodal proteins, disruption of the paranodal junction resulted in redistribution of ADAM22 into paranodal zones. Analysis of Caspr2-, PSD-93-, PSD-95-, and double PSD-93/PSD-95-null mice showed ADAM22 clustering at BCTs requires PSD-95, but ADAM22 clustering at juxtaparanodes requires neither PSD-93 nor PSD-95. In direct contrast, analysis of ADAM22-null mice demonstrated juxtaparanodal clustering of PSD-93 and PSD-95 requires ADAM22, whereas Kv1.2 and Caspr2 clustering is normal in ADAM22-null mice. Thus, ADAM22 is an axonal component of the Kv1 K(+) channel complex that recruits MAGUKs to juxtaparanodes.