gebhart/patrepeval huggingface dataset:
Control algorithm and flight simulation integration using the open control platform for unmanned aerial vehicles (2003)

In order for Unmanned Aerial Vehicles (UAVs) to exhibit increasing degrees of autonomy; heterogeneous control system software needs to be able to collaborate and reconfigure to varying mission conditions. Currently this ability is very limited due to inadequate software architectures on which the control systems are implemented. This paper describes an integration platform that adopts an open systems approach to integrating heterogeneous control algorithms. This platform was applied to real-time piloted and unpiloted simulations of a helicopter UAV while testing the performance of an adaptive controller as well as the ability to reconfigure during a main rotor collective actuator failure. Results indicate that the chosen architecture can greatly increase the ability to integrate heterogeneous components in a seamless fashion into a collaborating set of resources that achieve the desired mission functionality. This paper describes the integration of flight modeling and visualization with control algorithms.
The Ocean Drilling Program III: The shipboard laboratories on "JOIDES Resolution" (1985)

JOIDES Resolution (a.k.a. SEDCO/BP 471), the scientific drillship of the National Science Foundation's Ocean Drilling Program, contains over 12,000 square feet of laboratory space. Years of experience gained in the previous JOIDES program of scientific ocean drilling (the Deep Sea Drilling Project) have provided many ideas for improving upon the capabilities of a scientific drillship. Each laboratory on JOIDES Resolution is designed to include state-of-the-art equipment and techniques. A laboratory module seven stories high was added to the ship. This allows for ship investigations of sedimentology, physical properties, paleomagnetics, chemistry, petrography, and paleontology. In addition, thin section, X-ray diffraction/X-ray fluorescence, underway geophysics, logging and downhole measurement, computer, photographic, core storage, and library facilities are all available. This paper emphasizes the new instrumentation that was acquired or developed for the laboratories. Some techniques and equipment are in use for the first time at sea. Our experiences with these through the program's early cruises are related. The program plans to continually update its shipboard laboratory capability.
High recording performance of Co–Cr medium sputter-deposited at high Ar pressure and high substrate temperature (1996)

Co–Cr films were prepared by sputter deposition at a high Ar pressure of 70 Pa with elevated substrate temperatures up to 400 °C. Films of 100 nm thickness were deposited using a 19 at. % Cr–Co target onto a well c-axis oriented Ti underlayer prepared on glass disk substrates. The perpendicular coercivity, Hc⊥, of the films increased from 660 to 1940 Oe with increasing temperature. The films with high Hc⊥ exhibited a dense fine microstructure with distinct grain boundaries. The recording performance of the disk samples were measured by using a metal in gap type ring head, comparing with that of conventional Co–Cr films deposited at a low Ar pressure of 0.2 Pa. It was found that the high pressure deposited Co–Cr film exhibited higher output by more than 2 dB at the densities below 320 kFRPI (flux reversals per inch) compared with the conventional film with the same high coercivity. The D50* of as high as 250 kFRPI and the highest recordable density of over 600 kFRPI were confirmed for the new type of Co–Cr film deposited at 70 Pa and at 400 °C. The noise level of the film, however, was slightly higher than that of conventional method films, disagreeing with the suggestion of the microstructure.
알레르기 비염 한약제제 KOB와 주요 구성약물인 황기(黃氣)의 난알부민 유도 알레르기 비염 마우스에서의 항알레르기 효능 연구 (2012)

Objectives : In this study, we investigated the effect of KOB, a polyherbal medicine for allergic rhinitis and its main herb, Astragali Radix on allergic responses in ovalbumin (OVA)-induced Allergic rhinitis(AR) mice. Methods : Sprague Dawley (SD)-rats were orally administrated with KOB (500 ㎎/㎏), Astragali Radix water extract (ARW, 100 ㎎/㎏) or anti-histamine drug, dosodium cromoglycate (50 ㎎/㎏) as a reference drug, and then intraperitoneally injected with compound 48/80 (8 ㎎/㎏). Rats were measured the mortality and serum levels of histamine. BALB/c mice were orally administrated with KOB (500 ㎎/㎏), ARW (100 ㎎/㎏) or anti-histamine drug, Ketotifen (10 ㎎/㎏) as a reference drug, followed by sensitization and challenge of OVA. Mice were measured the serum levels of histamine and IgE, and observed histopathological changes of nasa mucosa H&E staining. Results : KOB and ARW significantly decreased the mortality and the serum levels of histamine in compound 48/80-induced anaphylatic rats. KOB and ARW also decreased the serum levels of histamine and IgE in OVA-induced AR mice, and inhibited histopathological changes of nasal mucosa with inflammation and the eosinophils infilteration. Conclusions : These data suggest that KOB has a strong anti-allergic effect through the inhibitory property of Astragali Radix, the main component of KOB against allergic responses in allergic rhinitis.
Distribution of 3 H-Thymidine in Arabidopsis Vegetative Meristems after 5-Iododeoxyuridine Treatment (1972)

Arabidopsis thaliana vegetative meristems, growing under short photoperiods, respond to the application of IUdR by precocious floral morphogenesis. 3H-thymidine was used to label cells active in DNA synthesis and study the effect of analogue application on the amount and distribution of DNA synthesis throughout the meristem during 78 hr subsequent to IUdR treatment. Photomicrographs, autoradiographs, and composite plots of label distribution in transparent superimposed sequential sections revealed a non-uniform distribution of labelling in control vegetative meristems, which typically contained a central and axial core incorporating little 3H-thymidine and a peripheral flanking tunica region which contained densely labelled cells. The ratio of labelled cells in the peripheral region to labelled cells in the central region was about 10:1 in the controls. In meristems pretreated with IUdR there was a brief suppression of 3H-thymidine incorporation during 6–12 hr after treatment, followed by two waves of enhanced incorporation in the peripheral region, and a progressive increase in the frequency of labelled cells in the central core of the meristem. After 78 hr the frequency of labelled cells in the central core of IUdR-treated meristems was 8-fold higher than in untreated meristems, and the frequency in the peripheral regions was about the same in both IUdR and control series. The enhancement in amount and uniformity of DNA synthesis after temporary inhibition by IUdR parallels the normal enhancement which is observed when vegetative meristems are transferred to long photoperiods causing floral induction.
Staphylococcus aureus Sortase A-Mediated Incorporation of Peptides: Effect of Peptide Modification on Incorporation (2016)

The endogenous Staphylococcus aureus sortase A (SrtA) transpeptidase covalently anchors cell wall-anchored (CWA) proteins equipped with a specific recognition motif (LPXTG) into the peptidoglycan layer of the staphylococcal cell wall. Previous in situ experiments have shown that SrtA is also able to incorporate exogenous, fluorescently labelled, synthetic substrates equipped with the LPXTG motif (K(FITC)LPETG-amide) into the bacterial cell wall, albeit at high concentrations of 500 μM to 1 mM. In the present study, we have evaluated the effect of substrate modification on the incorporation efficiency. This revealed that (i) by elongation of LPETG-amide with a sequence of positively charged amino acids, derived from the C-terminal domain of physiological SrtA substrates, the incorporation efficiency was increased by 20-fold at 10 μM, 100 μM and 250 μM; (ii) Substituting aspartic acid (E) for methionine increased the incorporation of the resulting K(FITC)LPMTG-amide approximately three times at all concentrations tested; (iii) conjugation of the lipid II binding antibiotic vancomycin to K(FITC)LPMTG-amide resulted in the same incorporation levels as K(FITC)LPETG-amide, but much more efficient at an impressive 500-fold lower substrate concentration. These newly developed synthetic substrates can potentially find broad applications in for example the in situ imaging of bacteria; the incorporation of antibody recruiting moieties; the targeted delivery and covalent incorporation of antimicrobial compounds into the bacterial cell wall.
Compiler-assisted preferred caching for embedded systems with STT-RAM based hybrid cache (2012)

As technology scales down, energy consumption is becoming a big problem for traditional SRAM-based cache hierarchies. The emerging Spin-Torque Transfer RAM (STT-RAM) is a promising replacement for large on-chip cache due to its ultra low leakage power and high storage density. However, write operations on STT-RAM suffer from considerably higher energy consumption and longer latency than SRAM. Hybrid cache consisting of both SRAM and STT-RAM has been proposed recently for both performance and energy efficiency. Most management strategies for hybrid caches employ migration-based techniques to dynamically move write-intensive data from STT-RAM to SRAM. These techniques lead to extra overheads. In this paper, we propose a compiler-assisted approach, preferred caching, to significantly reduce the migration overhead by giving migration-intensive memory blocks the preference for the SRAM part of the hybrid cache. Furthermore, a data assignment technique is proposed to improve the efficiency of preferred caching. The reduction of migration overhead can in turn improve the performance and energy efficiency of STT-RAM based hybrid cache. The experimental results show that, with the proposed techniques, on average, the number of migrations is reduced by 21.3%, the total latency is reduced by 8.0% and the total dynamic energy is reduced by 10.8%.
Tacrolimus versus cyclosporin A: a comparative study on rat renal allograft survival (1999)

Although tacrolimus has been studied in a wide variety of experimental animal models, we are the first group to systematically study the effect of tacrolimus on rat renal allograft survival, as primary therapy and as anti-rejection therapy, in comparison with cyclosporin A (CyA). Renal grafts were transplanted from BN to LEW rats. Tacrolimus and CyA were administrated orally from day 0 for 50 days as primary therapy after grafting. Allografts were rejected after a median survival time (MST) of 8 days. Both tacrolimus und CyA significantly prolonged renal allograft survival, in a dose-dependent manner compared with the allograft controls. The most effective dose was 3.2 mg/kg, per day for tacrolimus, and 10 mg/kg per day for CyA. There was no significant difference in renal function between the group treated with the most effective dose of tacrolimus and the CyA-treated group. The percentage of detectable serum IL-2 level was 45 % in the allograft control group, but was undetectable in groups treated with the most effective dose of tacrolimus or CyA at days 3 and 6 after grafting. On the other hand, no side effects were noted in recipient rats by daily inspection, body weight change, and histological studies, although minimal tubular vacuolation was encountered in the group treated with CyA 32 mg/kg per day. In addition, the most effective doses of tacrolimus and CyA were studied as anti-rejection therapy. All of the 5 recipients treated with tacrolimus from days 2–14, and 3 of the 5 treated from days 4–16 after grafting, survived for more than 50 days. However, the MST was 19 days for recipients treated with CyA from days 2–14, and 13 days for those treated from days 4–16 after grafting. In summary, tacrolimus as primary therapy induced rat renal allograft survival with renal function and side effects comparable with those of CyA. Interestingly, when both agents were used as anti-rejection therapy, tacrolimus, but not CyA, could significantly overcome ongoing renal allograft rejection in the rat.
The Wound-Healing Potential of Olea europaea L. Cv. Arbequina Leaves Extract: An Integrated In Vitro, In Silico, and In Vivo Investigation (2022)

Olea europaea L. Cv. Arbequina (OEA) (Oleaceae) is an olive variety species that has received little attention. Besides our previous work for the chemical profiling of OEA leaves using LC−HRESIMS, an additional 23 compounds are identified. An excision wound model is used to measure wound healing action. Wounds are provided with OEA (2% w/v) or MEBO® cream (marketed treatment). The wound closure rate related to vehicle-treated wounds is significantly increased by OEA. Comparing to vehicle wound tissues, significant levels of TGF-β in OEA and MEBO® (p < 0.05) are displayed by gene expression patterns, with the most significant levels in OEA-treated wounds. Proinflammatory TNF-α and IL-1β levels are substantially reduced in OEA-treated wounds. The capability of several lignan-related compounds to interact with MMP-1 is revealed by extensive in silico investigation of the major OEA compounds (i.e., inverse docking, molecular dynamics simulation, and ΔG calculation), and their role in the wound-healing process is also characterized. The potential of OEA as a potent MMP-1 inhibitor is shown in subsequent in vitro testing (IC50 = 88.0 ± 0.1 nM). In conclusion, OEA is introduced as an interesting therapeutic candidate that can effectively manage wound healing because of its anti-inflammatory and antioxidant properties.
Dural Closure with Nonpenetrating Clips Prevents Meningoneural Adhesions: An Experimental Study in Dogs (1999)

This report is the first long-term experimental study comparing two fundamentally different methods for dural repair in a relevant animal model.
Electrically pumped continuous-wave 13 µm InAs/GaAs quantum dot lasers monolithically grown on on-axis Si (001) substrates (2017)

We report on the first electrically pumped continuous-wave (cw) InAs/GaAs quantum dot (QD) lasers monolithically grown on on-axis Si (001) substrates without any intermediate buffer layers. A 400 nm antiphase boundary (APB) free epitaxial GaAs film with a small root-mean-square (RMS) surface roughness of 0.86 nm was first deposited on a 300 mm standard industry-compatible on-axis Si (001) substrate by metal-organic chemical vapor deposition (MOCVD). The QD laser structure was then grown on this APB-free GaAs/Si (001) virtual substrate by molecular beam epitaxy (MBE). Room-temperature cw lasing at ~1.3 µm has been achieved with a threshold current density of 425 A/cm<sup>2</sup> and single facet output power of 43 mW. Under pulsed operation, lasing operation up to 102 °C has been realized, with a threshold current density of 250 A/cm<sup>2</sup> and single facet output power exceeding 130 mW at room temperature.
A Comparison of Cycle-Resolved and Ensemble-Averaged velocity variations in a Diesel Engine (1989)

&lt;div class="htmlview paragraph"&gt;Laser-Doppler anemometry was used to investigate mean flow and turbulence fields in a direct injection diesel engine, motored at speeds of 1500, 2250 and 3000 rev/min. Both cycle-resolved and ensemble-averaged measurements were made in the upper part of the cylinder during the inlet and compression strokes.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The cycle-resolved measurements in the inlet stroke indicated that the annular jet leaving the valve underwent rapid changes of direction at frequencies which varied from one point to another around the valve circumference. The cycle-resolved and ensemble-averaged measurements in the compression stroke both revealed a precession of the swirl centre around the cylinder axis, at a rate which was faster than the speed of rotation of the crankshaft.&lt;/div&gt;
A highly stereocontrolled route to the monensin spiroketal ring system (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA highly stereocontrolled route to the monensin spiroketal ring systemDavid M. Walba, William N. Thurmes, and R. Curtis HaltiwangerCite this: J. Org. Chem. 1988, 53, 5, 1046–1056Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://doi.org/10.1021/jo00240a022Request reuse permissionsArticle Views1120Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: A New Catalytic Asymmetric Approach to Polyfunctional Aldol Products Mediated by Zinc Organometallics. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
TLR5, a novel mediator of innate immunity‐induced osteoclastogenesis and bone loss (2015)

Accumulating evidence points to the importance of the innate immune system in inflammation-induced bone loss in infectious and autoimmune diseases. TLRs are well known for being activated by ligands expressed by bacteria, viruses, and fungi. Recent findings indicate that also endogenous ligands in inflammatory processes are important, one being a TLR5 agonist present in synovial fluid from patients with rheumatoid arthritis (RA). We found that activation of TLR5 by its specific ligand, flagellin, caused robust osteoclast formation and bone loss in cultured mouse neonatal parietal bones dependent on increased receptor activator of NF-κB ligand (RANKL):osteoprotegerin ratio, with half-maximal stimulation at 0.01 μg/ml. Flagellin enhanced Rankl mRNA in isolated osteoblasts by a myeloid differentiation primary response gene 88 and NF-κB-dependent mechanism. Injection of flagellin locally over skull bones in 5-wk-old mice resulted in increased mRNA expression of Rankl and osteoclastic genes, robust osteoclast formation, and bone loss. The effects in vitro and in vivo were absent in Tlr5(-/-) mice. These data show that TLR5 is a novel activator of RANKL and osteoclast formation and, therefore, a potential key factor in inflammation-induced bone erosions in diseases like RA, reactive arthritis, and periodontitis. TLR5 might be a promising novel treatment target for prevention of inflammatory bone loss.
Trends in the design of RFID tags (2011)

This communication is mainly dedicated to the design of RFID tags, in particular the antennas that allow the tag to be fed, communicate and exchange data with the reader. Good performance tags require optimized antenna that take into account numerous constraints as well as the environment of the application under consideration. Conventional tags based on IC chips as well as chipless or RF barccode are discussed. The last part of the communication will consider how to transform a tag into an RFID sensor thanks to a specific modification and accurate design of the tag antenna.
Vorläufige Beschreibungen neuer papuanischer Orchideen, XIII (1915)

Caulis erectus, 48 cm. longus, inferne longitudine 28 cm. vaginatus, parte superiore foliatus. Folia 8, lanceolata, acute acuminata, 8â17 cm. longa, 2â3.5 cm lata. Inflorescentia laxius 20- flora, pedunculo 12 cm. longo, rachide 9cm. longa. Bracteae ovatae, longe acuminatae, ad 2 cm longae. Flores 1.85 cm. longi. Sepala ovata, apiculata, 3 nervia, 0.825 et 0.9 cm. longa, 0.5 et 0.43 cm. lata. Petala alte bipartita, lacinia postica erecta, lineari, falcata, obtusa, 2 nervia, toto 0.7 cm. longa, lacinia antica adscendente, lineari-subulata, 1 nervia, 0.8â0.87 cm. longa. Labellum 3 partitum, lacinia intermedia lineari, subacuta, 0.85â0.95 cm. longa, lateralibus anguste linearibus, medio nonnullis lacinulis brevibus et dentibus munitis, 0.65-0.8 cm. longis, calcari pendulo, subcylindrico, vix clavato, obtuso, 1 cm. longo. Anthera 2 loba, thecis parallelis. Rostelli laciniae laterales lineares, intermedia triangula. Processus stigmatici oblongi, antherae canales superantes. Ovarium pedicellatum 1.6 cm. longum.\nNiederl. Neu-Guinea: Geelvink-Bai, Jabi-Gebirge bei Wappe. (R. F. JANOWSKY n. 339).
Galactose-conjugated antibodies in cancer therapy: properties and principles of action. (1991)

Galactose conjugation of antibodies causes them to be recognized by the hepatic asialoglycoprotein receptor and therefore cleared very rapidly from the blood. In these investigations, some effector functions of galactose-conjugated antibodies were assayed, and several applications to experimental tumors in vivo were demonstrated. Galactose conjugation did not interfere with two antibody functions in addition to antigen binding, namely complement-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity. This conjugation procedure was originally developed for its potential use in localized immunotherapy, such as i.p. Injection of galactose-antibody conjugates i.p. demonstrated, more conclusively than other methods that have been used, that the presence of ascites causes prolonged retention of antibody in the peritoneal cavity and that this effect is correlated with the volume of ascites present. In mice bearing i.p. tumor xenografts, i.p. injection of galactose-antibody conjugates resulted in high tumor/nontumor ratios at 28 h after antibody injection, with values of 40:1, 43:1, 77:1, and 11:1 for the blood, kidney, lung, and spleen, respectively, although the ratio was only 4:1 for the liver. Control experiments demonstrated that i.p. injection of unconjugated antibody or a galactose-conjugated nonreactive antibody produced much lower tumor/nontumor ratios. In investigations of possible systemic application of galactose-antibody conjugates, we found that injection of large amounts of an inhibitor that binds competitively to the hepatic receptor, asialo-bovine submaxillary mucin, can block clearance of galactose-conjugated antibodies for 2-3 days. In this way, high blood levels of antibody can be maintained for 2-3 days, thus allowing penetration and binding to solid tumors, followed by very rapid blood clearance. With this approach, using a human carcinoma growing s.c. in nude mice, high tumor/nontumor ratios were obtained 4 days after injection, with mean values of 43:1, 18:1, 17:1, and 15:1 for the blood, kidney, lung, and spleen, respectively, although the ratio for the liver was only 1.7:1. The blood level at this time was 0.04 +/- 0.02% (SD) of the injected dose/g, while the tumor level was 1.69 +/- 1.29% of the injected dose/g. In conclusion, galactose-conjugated antibodies appear to have diverse applications in regional or systemic immunotherapy.
Supplementary Table S2 from Metabolomic, DNA Methylomic, and Transcriptomic Profiling of Suberoylanilide Hydroxamic Acid Effects on LPS-Exposed Lung Epithelial Cells (2023)

&lt;p&gt;Supplementary Table S2 shows the list of metabolites that were examined among control, LPS, and LPS + SAHA groups after 3 and 24 h treatments.&lt;/p&gt;