gebhart/patrepeval huggingface dataset:
Self-regulation of the medical profession in Australia - an update (1999)

The past ten years have seen striking changes in the accountability of the medical profession under the umbrella of self- regulation. This brief article describes broadly the multiple processes by which self-regulation aims to fulfil its primary purpose of protecting the public. It highlights the changes that have continued to strengthen these processes, particularly by greatly increasing community input into self-regulation, and identifies other processes that contribute to community protection. (author abstract)
Treatment of patient-dependent beam modifiers in photon treatments by the Monte Carlo dose calculation code PEREGRINE (1997)

The goal of the PEREGRINE Monte Carlo Dose Calculation Project is to deliver a Monte Carlo package that is both accurate and sufficiently fast for routine clinical use. One of the operational requirements for photon-treatment plans is a fast, accurate method of describing the photon phase-space distribution at the surface of the patient. The open-field case is computationally the most tractable; we know, a priori, for a given machine and energy, the locations and compositions of the relevant accelerator components (i.e., target, primary collimator, flattening filter, and monitor chamber). Therefore, we can precalculate and store the expected photon distributions. For any open-field treatment plan, we then evaluate these existing photon phase-space distributions at the patient`s surface, and pass the obtained photons to the dose calculation routines within PEREGRINE. We neglect any effect of the intervening air column, including attenuation of the photons and production of contaminant electrons. In principle, for treatment plans requiring jaws, blocks, and wedges, we could precalculate and store photon phase-space distributions for various combinations of field sizes and wedges. This has the disadvantage that we would have to anticipate those combinations and that subsequently PEREGRINE would not be able to treat other plans. Therefore, PEREGRINE tracks photons through the patient-dependent beam modifiers. The geometric and physics methods used to do this are described here. 4 refs., 8 figs.
Extending a Tool Integration Language (2005)

The Marvel environment supports rule-based automation of software processes. Marvel invokes external tools to carry out steps in a software process. One of the major objectives of this research is to invoke external tools to carry out steps in a software process without modifying the tools. This is achieved by encapsulating tools in envelopes, designed to abstract the details of a tool from the Marvel kernel, thereby providing a "black box" interface. Initially we used the Unix shell script language to write envelopes. However, due to several limitations of the shell language the black box abstraction could not be fully supported. We describe these limitations and discuss how we extended the shell language to obtain a new envelope language that fully supports the black box abstraction.
Forschungsfragen und Methode (1994)

Wie im letzten Abschnitt gezeigt werden konnte, setzt sich die zunächst in Alltagszusammenhängen festgestellte Ambivalenz der Bewertung des Glücksspiels in den Normen, bis hin zu den Rechtsnormen fort. Während einige Spielarten erlaubt sind und mit staatlicher Genehmigung betrieben werden, werden andere mit Strafen belegt. Eine Ablehnung des Glücksspiels macht sich vermutlich an seiner ungenügenden Funktionalisierbarkeit und daran, daß es ein ‘problematisches’ bzw. ‘süchtiges’ Spielen zu geben scheint, fest. Der skeptischen Beurteilung steht eine starke Anziehungskraft der Glücksspiele entgegen, die durch ihren spannungsaufbauenden Risikogehalt begründet sein mag. Dieses Ergebnis spiegelt sich in der Forschung wieder: Brengelmann134 stellte fest, daß einer häufigen Ausübung des Glücksspiels eine Beurteilung als ‘wertlos’ entgegenstehen kann, die intra-oder interpersonale Konflikte bedingen könnte.
Stable, concentrated solutions of polyaniline using amines as gel inhibitors (2023)

Stable, concentrated solutions of high-molecular weight polyaniline using amines as gel inhibitors. Certain amine compounds (gel inhibitors) are used to form highly concentrated, stable solutions of the emeraldine base form of polyaniline in numerous organic solvents from which coatings, films and fibers are readily prepared without problems associated with rapid gelation which occurs when concentrated solutions are attempted without the use of the gel inhibitors of the present invention. Tertiary amines are used to solubilize low-molecular weight fractions (M.sub.w <120,000, M.sub.n <30,000) of the pernigraniline, emeraldine, and leucoemeraldine oxidation states of polyaniline as concentrated (>20 wt. %) polyaniline solutions, while primary and secondary amines are used to produce solutions having 15-40 wt % of high-molecular weight polyaniline [M.sub.w.gtoreq.120,000, M.sub.n.gtoreq.30,000]. Concentrated solutions of polyaniline co-polymers or ring and/or nitrogen-substituted polyanilines may also be prepared.
Innate immune responses in hepatitis C virus infection (2020)

Hepatitis C virus (HCV) is a major causative agent of chronic hepatitis and hepatocellular carcinoma worldwide and thus poses a significant public health threat. A hallmark of HCV infection is the extraordinary ability of the virus to persist in a majority of infected people. Innate immune responses represent the front line of defense of the human body against HCV immediately after infection. They also play a crucial role in orchestrating subsequent HCV-specific adaptive immunity that is pivotal for viral clearance. Accumulating evidence suggests that the host has evolved multifaceted innate immune mechanisms to sense HCV infection and elicit defense responses, while HCV has developed elaborate strategies to circumvent many of these. Defining the interplay of HCV with host innate immunity reveals mechanistic insights into hepatitis C pathogenesis and informs approaches to therapy. In this review, we summarize recent advances in understanding innate immune responses to HCV infection, focusing on induction and effector mechanisms of the interferon antiviral response as well as the evasion strategies of HCV.
C2 Design of single-bounce monocapillary X-ray optics (2006)

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Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome (1994)

No major pathophysiologic or therapeutic findings have appeared over the past year regarding fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome, three poorly understood, controversial, and overlapping syndromes. The frequent prevalence of these disorders in association with Lyme disease and other medical and psychiatric illness was emphasized. New studies demonstrated the potential role for central nervous system activation in fibromyalgia and chronic fatigue syndrome.
[Clinical features of primary and secondary atypical mycobacteriosis]. (1993)

A clinical investigation was carried out in 39 patients with atypical mycobacteriosis (AM). The patients at our hospital diagnosed as having AM during an 11-year period from 1981 to 1991 were reviewed in this study. The incidence of AM among all of mycobacterial infections has been increasing since 1988. The atypical mycobacteria detected included M. avium complex (MAC) in 79%, M. kansasii in 26%, and other organisms in 5%. Patients who had primary infection without underlying respiratory disease were compared with those who had secondary infection. In secondary infection, MAC was detected in the sputum of a high percentage of patients and was positive for more than 6 months despite therapy. Gamma globulin levels were also increased in patients with secondary infection. Cell mediated immunity was examined by the DNCB reaction and the detection of CD4- and CD8- positive T lymphocytes. The DNCB skin reaction was positive in 6 out of 26 patients with secondary infection. The percentage of CD8- positive T lymphocytes was higher in patients with secondary disease. Fischer's ratio (indicating the balance of plasma amino acids) was also examined as an index of the nutritional status. It was significantly lower in secondary infection compared with primary infection. Moreover, secondary infection was associated with a lower positive rate for the DNCB skin reaction and a lower Fischer's ratio when compared with pulmonary tuberculosis. Thus impairment of cell-mediated immunity, malnutrition, and a poor prognosis were significantly more common in secondary infection compared with primary infection.
Articular responses to purified cartilage proteoglycans (1988)

To examine whether proteoglycans (PGs) liberated from cartilage might contribute to articular changes in arthritis, cartilage PGs were injected intraarticularly into rabbit knee joints. Twice-weekly injections of PG (2.5 mg) provoked synovial hypertrophy, synovitis, erosion of the articulating surfaces, and loss of metachromasia of the articular cartilage. These changes were accompanied by a marked elevation in the production of neutral collagenase and gelatinase by both synoviocytes and chondrocytes. The synoviocytes of experimental knee joints also produced factor(s), possibly related to interleukin-1, which provoked the activation of chondrocytes. Our data are consistent with the idea that free PG fragments mediate some of the pathophysiologic changes that occur in arthritic joints. This property may be particularly important in osteoarthritis.
Abstract 4428: Similar Response to Spironolactone in Whites and African American Patients with Resistant Hypertension (2008)

Primary aldosteronism (PA) is a common cause of resistant hypertension with a prevalence of approximately 20%. Spironolactone is the drug of choice for the medical management of patients with PA. Blacks have been reported to have low-renin HTN and respond better to diuretics and calcium channel blockers. Racial differences in response to spironolactone in patients with resistant hypertension have not been previously described. Consecutive subjects referred to the University of Alabama at Birmingham hypertension clinic for resistant hypertension had been evaluated with a plasma aldosterone concentration (PAC), plasma renin activity (PRA), and a 24-hr urine collection for aldosterone, sodium, and potassium during the patient’s usual diet. The BP response to spironolactone was compared retrospectively in patients. For clinical reasons, subjects had been treated with a median dose of 25 mg of spironolactone and the BP response at 6 weeks, 3 and 6 months was compared retrospectively. A total of 117 patients with resistant hypertension were included in the analysis, including 59 white and 58 black subjects. Both groups had a similar number of antihypertensive medications at baseline. PAC, PRA, U-aldo and serum potassium levels were also similar. BP reduction at 6-weeks, 3- and 6-months after treatment with spironolactone was similar in black and white subjects. At 3 months, the mean reduction in systolic BP was −19.5±19.0 and −23.2±20.0 for blacks and whites, respectively (p= 0.321). These data indicate that African American and white subjects with resistant hypertension respond equally well to spironolactone.
Rydberg atom wave packets localized in the angular coordinates (1986)

The quantum theory of atoms is based on a Hamiltonian which is just that of the classical Kepler theory of planetary orbits. In spite of this common foundation, the predictions of quantum theory ordinarily do not much resemble those of classical theory. Even in the limit of large quantum numbers the energy eigenstates of quantum theory do not look at all like the classical elliptical orbits. Recently, Parker and Stroud 1 have shown that it is possible to excite a Rydberg atom wave packet whose radial dependence resembles the classical ideal of a particle traveling in an elliptical orbit. In this paper we discuss the formation of a wave packet in the polar and azimuthal angles by the coherent excitation of Rydberg states with the same principal quantum, but with a distribution of the angular momentum quantum numbers. When this wave packet is formed of the Rydberg states of an alkali atom the connection with classical theory is again striking. The wave packet precesses due to the core polarization, just as the classical elliptical orbit precesses due to an added r –4 perturbing potential.
Controlled cross‐linking of porcine cholecyst extracellular matrix for preparing tissue engineering scaffold (2019)

Treatment with cross-linking agents for stabilizing biomolecules is an integral step during the preparation of many extracellular matrix-based tissue engineering scaffolds from mammalian organs. However, excess cross-linking may cause nonavailability of biomolecules and consequent deterioration of bioinductive properties of the scaffold. The present study considered controlling the extent of cross-linking in a porcine cholecyst extracellular matrix scaffold prepared by a nonenzymatic and nondetergent method, by ex situ incubation of the source organ in varying concentrations of neutral buffered formaldehyde (10, 4, 1 or 0%; v/v) for in situ cross-linking of biomolecules. Reduction of the formaldehyde concentration resulted in an increase in the extent of biodegradation and a decrease in the compactness of the mesh-like surface microarchitecture of the scaffold. Retention of collagen was maximum when treated with 10% neutral buffered formaldehyde without any variation in the content of elastin and sulphated glycosaminoglycans. Although there was a reduction in the quantity of growth factors following the cross-linking, fibroblasts remained viable on the scaffolds. The retention of major biomolecule was maximum and autodigestion was minimum in the scaffold prepared by the ex situ treatment of cholecyst in 10% neutral buffered formalin and found suitable for preparing the tissue engineering scaffold.
Caspase-1 Inhibitor Reduces Severity ofPseudomonas aeruginosaKeratitis in Mice (2004)

Downregulation of IL-1beta by ICE together with ciprofloxacin to kill bacteria may provide alternate therapy to current treatment.
Proangiogenic effects of tumor cells on endothelial progenitor cells vary with tumor type in an in vitro and in vivo rat model (2018)

Endothelial progenitor cells (EPCs) contribute to neovascularization in tumors. However, the relationship of EPCs and tumor-induced angiogenesis still remains to be clarified. The present study aimed at investigating the influence of 4 different tumor types on angiogenic properties of EPCs in an in vitro and in vivo rat model. It could be demonstrated that in vitro proliferation, migration, and angiogenic abilities and genetic modifications of EPCs are controlled in a tumor-type-dependent manner. The proangiogenic effect of mammary carcinoma, osteosarcoma, and rhabdomyosarcoma cells was more pronounced compared to colon carcinoma cells. Coinjection of encapsulated tumor cells, especially mammary carcinoma cells, and EPCs in a rat model confirmed a contributing effect of EPCs in tumor vascularization. Cytokines secreted by tumors such as monocyte chemoattractant protein 1, macrophage inflammatory protein 2, and TNF-related apoptosis-inducing ligand play a pivotal role in the tumor cell-EPC interaction, leading to enhanced migration and angiogenesis. With the present study, we were able to decipher possible underlying mechanisms by which EPCs are stimulated by tumor cells and contribute to tumor vascularization. The present study will contribute to a better understanding of tumor-induced vascularization, thus facilitating the development of therapeutic strategies targeting tumor-EPC interactions.-An, R., Schmid, R., Klausing, A., Robering, J. W., Weber, M., Bäuerle, T., Detsch, R., Boccaccini, A. R., Horch, R. E., Boos, A. M., Weigand, A. Proangiogenic effects of tumor cells on endothelial progenitor cells vary with tumor type in an in vitro and in vivo rat model.
Exploiting choice (1996)

Simultaneous multithreading is a technique that permits multiple independent threads to issue multiple instructions each cycle. In previous work we demonstrated the performance potential of simultaneous multithreading, based on a somewhat idealized model. In this paper we show that the throughput gains from simultaneous multithreading can be achieved without extensive changes to a conventional wide-issue superscalar, either in hardware structures or sizes. We present an architecture for simultaneous multithreading that achieves three goals: (1) it minimizes the architectural impact on the conventional superscalar design, (2) it has minimal performance impact on a single thread executing alone, and (3) it achieves significant throughput gains when running multiple threads. Our simultaneous multithreading architecture achieves a throughput of 5.4 instructions per cycle, a 2.5-fold improvement over an unmodified superscalar with similar hardware resources. This speedup is enhanced by an advantage of multithreading previously unexploited in other architectures: the ability to favor for fetch and issue those threads most efficiently using the processor each cycle, thereby providing the "best" instructions to the processor.
Real-Time Detection and 3D Localization of Coronary Atherosclerosis Using a Microwave Imaging Technique: A Simulation Study (2022)

Obtaining the exact position of accumulated calcium on the inner walls of coronary arteries is critical for successful angioplasty procedures. For the first time to our knowledge, in this work, we present a high accuracy imaging of the inner coronary artery using microwaves for precise calcium identification. Specifically, a cylindrical catheter radiating microwave signals is designed. The catheter has multiple dipole-like antennas placed around it to enable a 360° field-of-view around the catheter. In addition, to resolve image ambiguity, a metallic rod is inserted along the axis of the plastic catheter. The reconstructed images using data obtained from simulations show successful detection and 3D localization of the accumulated calcium on the inner walls of the coronary artery in the presence of blood flow. Considering the space and shape limitations, and the highly lossy biological tissue environment, the presented imaging approach is promising and offers a potential solution for accurate localization of coronary atherosclerosis during angioplasty or other related procedures.
The Newborn (1969)

Rabor, I. F.; Oh, William; Wu, P. Y. K.; Metcoff, Jack; Vaughn, Mary A.; Gabler, Marjorie Author Information
On Election to the Fellowship of the American Academy of Microbiology (2022)

Election to the American Academy of Microbiology (AAM) fellowship is among the greatest honors that a scientist working in the fields of microbial sciences can receive in their lifetime. In recent years, the AAM has pursued reform and renewal of the fellowship election, and this included formalizing the election process to make it more transparent, equitable, and inclusive. In this editorial, we detail the mechanics of the election process and provide advice to nominators and nominees in the form of frequently asked questions.
Anti-allergic Activity of Naringenin Chalcone from a Tomato Skin Extract (2004)

The anti-allergic activity of a tomato extract was studied by using an in vitro histamine-release assay. The tomato skin extract exerted the strongest inhibition of histamine release. Chlorogenic acid, rutin and naringenin were identified in the 60% ethanol extract of tomato skin. However, the extract contained an unknown compound which strongly inhibited histamine release. This active compound in tomato skin was identified as naringenin chalcone (trans-2'4'6'4-tetrahydroxychalcone). Naringenin chalcone inhibited histamine release with an IC(50) value of 68 microg/ml. The anti-allergic activity of the tomato skin extract was next investigated by the in vivo mouse ear-swelling response. We found that naringenin chalcone showed the strongest inhibitory effect of the polyphenols of the tomato skin extract. These results indicate that a tomato skin extract could inhibit allergic reactions.
Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration (2021)

Glioblastoma (GBM) is the most lethal primary brain tumor characterized by significant cellular heterogeneity, namely tumor cells, including GBM stem-like cells (GSCs) and differentiated GBM cells (DGCs), and non-tumor cells such as endothelial cells, vascular pericytes, macrophages, and other types of immune cells. GSCs are essential to drive tumor progression, whereas the biological roles of DGCs are largely unknown. In this study, we focused on the roles of DGCs in the tumor microenvironment. To this end, we extracted DGC-specific signature genes from transcriptomic profiles of matched pairs of in vitro GSC and DGC models. By evaluating the DGC signature using single cell data, we confirmed the presence of cell subpopulations emulated by in vitro culture models within a primary tumor. The DGC signature was correlated with the mesenchymal subtype and a poor prognosis in large GBM cohorts such as The Cancer Genome Atlas and Ivy Glioblastoma Atlas Project. In silico signaling pathway analysis suggested a role of DGCs in macrophage infiltration. Consistent with in silico findings, in vitro DGC models promoted macrophage migration. In vivo, coimplantation of DGCs and GSCs reduced the survival of tumor xenograft-bearing mice and increased macrophage infiltration into tumor tissue compared with transplantation of GSCs alone. DGCs exhibited a significant increase in YAP/TAZ/TEAD activity compared with GSCs. CCN1, a transcriptional target of YAP/TAZ, was selected from the DGC signature as a candidate secreted protein involved in macrophage recruitment. In fact, CCN1 was secreted abundantly from DGCs, but not GSCs. DGCs promoted macrophage migration in vitro and macrophage infiltration into tumor tissue in vivo through secretion of CCN1. Collectively, these results demonstrate that DGCs contribute to GSC-dependent tumor progression by shaping a mesenchymal microenvironment via CCN1-mediated macrophage infiltration. This study provides new insight into the complex GBM microenvironment consisting of heterogeneous cells.
Redundant sensorized arm+hand system for space telerobotized manipulation (1989)

An integrated system, composed of an arm, a wrist, and a mechanical multifingered hand is treated. The hand is on development for possible application in telemanipulation, and is realized in separate parts. The redundancy of the degrees of freedom of the system, the sensors, the application of logical rules, and the supervision of teleoperators may be applied in order to have an optimum of reliability of the system in space telemanipulations.