gebhart/patrepeval huggingface dataset:
Magnetic and polar phases and dynamical clustering in multiferroic layered solid solutions CuCr1−xInxP2S6 (2011)

The lamellar antiferromagnet CuCr${}_{1\ensuremath{-}x}$In${}_{x}$P${}_{2}$S${}_{6}$ (${T}_{N}$ \ensuremath{\approx} 32 K) rapidly loses magnetic percolation upon diamagnetically diluting the triangular Cu-Cr-P${}_{2}$ planar network with In${}^{3+}$ ions. For 0 \ensuremath{\le} $x$ 0.3 anti-ferroelectricity (${T}_{c}$ \ensuremath{\le} 150 K) and antiferromagnetic spin order (${T}_{N}$ \ensuremath{\le} 32 K) coexist. Both orders are superposed by ferroic fluctuations. Dynamic polar clustering with glasslike polydispersive dielectric susceptibility emerges for $x$ &gt; 0 at $T$ \ensuremath{\le} ${T}_{c}$, while for $x$ 0.3 pseudocritical planar 2D ferromagnetic fluctuations are encountered. They give rise to Langevin-type magnetization saturation and large quasimolecular magnetic anisotropy. Third-order magnetoelectric coupling is observed in collinear field configuration.
Smart functional nucleic acid chimeras: Enabling tissue specific RNA targeting therapy (2015)

A major obstacle for effective utilization of therapeutic oligonucleotides such as siRNA, antisense, antimiRs etc. is to deliver them specifically to the target tissues. Toward this goal, nucleic acid aptamers are re-emerging as a prominent class of biomolecules capable of delivering target specific therapy and therapeutic monitoring by various molecular imaging modalities. This class of short oligonucleotide ligands with high affinity and specificity are selected from a large nucleic acid pool against a molecular target of choice. Poor cellular uptake of therapeutic oligonucleotides impedes gene-targeting efficacy in vitro and in vivo. In contrast, aptamer-oligonucleotide chimeras have shown the capacity to deliver siRNA, antimiRs, small molecule drugs etc. toward various targets and showed very promising results in various studies on different diseases models. However, to further improve the bio-stability of such chimeric conjugates, it is important to introduce chemically-modified nucleic acid analogs. In this review, we highlight the applications of nucleic acid aptamers for target specific delivery of therapeutic oligonucleotides.
The innate immunity in the cnidarian Hydra vulgaris (2009)

Hydra vulgaris is currently receiving increased attention as a genetically tractable invertebrate model system for studying important processes of life such as the innate immune defense. Similar to complex animals, H. vulgaris polyps respond to injury by abrupt muscle contraction, by limited escape behavior, and by healing the damaged tissue. Simultaneously, cellular processes such as phagocytosis and programmed cell death as well as the massive production of antimicrobial peptides are induced. Recent studies identified several molecular pathways controlling these responses; however, the interdependence of innate immunity and, for example, regeneration and tissue remodeling is not well elucidated yet. H. vulgaris belongs to the Cnidaria representing the phylogenic sister group of bilaterian animals; hence, a better understanding of evolutionarily conserved as well as Hydra/Cnidaria-specific immune responses will provide deep insight into both origin and evolution of the animal innate immune system
Do you have the time? Composition and linking in time-based hypermedia (1999)

Article Do you have the time? Composition and linking in time-based hypermedia Share on Authors: Lynda Hardman CWI, P.O. Box 94079, 1090 GB Amsterdam, The Netherlands CWI, P.O. Box 94079, 1090 GB Amsterdam, The NetherlandsView Profile , Jacco van Ossenbruggen CWI, P.O. Box 94079, 1090 GB Amsterdam, The Netherlands CWI, P.O. Box 94079, 1090 GB Amsterdam, The NetherlandsView Profile , K. Sjoerd Mullender CWI, P.O. Box 94079, 1090 GB Amsterdam, The Netherlands CWI, P.O. Box 94079, 1090 GB Amsterdam, The NetherlandsView Profile , Lloyd Rutledge CWI, P.O. Box 94079, 1090 GB Amsterdam, The Netherlands CWI, P.O. Box 94079, 1090 GB Amsterdam, The NetherlandsView Profile , Dick C. A. Bulterman CWI, P.O. Box 94079, 1090 GB Amsterdam, The Netherlands CWI, P.O. Box 94079, 1090 GB Amsterdam, The NetherlandsView Profile Authors Info & Claims HYPERTEXT '99: Proceedings of the tenth ACM Conference on Hypertext and hypermedia : returning to our diverse roots: returning to our diverse rootsFebruary 1999 Pages 189–196https://doi.org/10.1145/294469.294515Online:01 February 1999Publication History 15citation505DownloadsMetricsTotal Citations15Total Downloads505Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Increased tumour angiogenesis in SOX11‐positive mantle cell lymphoma (2019)

These findings suggest that SOX11 promotes an angiogenic phenotype in primary MCL, which may contribute to the more aggressive behaviour of these tumours.
Building National Electronic Medical Record Systems via the World Wide Web (1996)

Electronic medical record systems (EMRSs) currently do not lend themselves easily to cross-institutional clinical care and research. Unique system designs coupled with a lack of standards have led to this difficulty. The authors have designed a preliminary EMRS architecture (W3-EMRS) that exploits the multiplatform, multiprotocol, client-server technology of the World Wide Web. The architecture abstracts the clinical information model and the visual presentation away from the underlying EMRS. As a result, computation upon data elements of the EMRS and their presentation are no longer tied to the underlying EMRS structures. The architecture is intended to enable implementation of programs that provide uniform access to multiple, heterogeneous legacy EMRSs. The authors have implemented an initial prototype of W3-EMRS that accesses the database of the Boston Children's Hospital Clinician's Workstation.
Breakable stent for interventions in infants and neonates: an animal study and histopathological findings (2005)

The new breakable stent can be broken open by simple angioplasty. Feasibility, effectiveness, and biocompatibility were shown in an animal model. Surgery to remove stents from paediatric patients due to disproportion between a previously implanted stent and the growing vessel may be avoided by the use of a breakable stent.
Bimodal Effect of Lithium Plasma Levels on Hippocampal Glutamate Concentrations in Bipolar II Depression: A Pilot Study (2015)

These preliminary results suggest that lithium has a bimodal action in hippocampal glutamate concentration depending on the plasma levels.
Effects of Media on the Fungal Metabolome (2013)

Variation in the growing environment (e.g. temperature, pH, nutrition) can have significant impacts on the quantity and diversity of fungal secondary metabolites. In the industrial setting, optimization of growing conditions can lead to significantly increased production of a compound of interest. Such optimization becomes much more difficult in a drug-discovery screening situation, as the ideal conditions for one organism may induce poor metabolic diversity for a different organism. The manipulation of culture growing conditions for the purpose of augmenting the natural metabolic diversity of microorganisms is often referred to as the OSMAC (one strain, many compounds) approach. Here, the impact of different media types on the secondary metabolite production of several fungal strains is examined in the context of the drug-discovery screening process.
Prehabilitation and heart failure: perspective in primary outcomes, a randomized controlled trial. (2021)

Because of our preliminary results, prehabilitation program should be included among the management strategies of in elderly patients with chronic heart failure to better manage their disease and to improve their Quality of Life.
2013 ESC guidelines on the management of stable coronary artery disease (2013)

2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology
Potential Therapeutic Agents and Associated Bioassay Data for COVID-19 and Related Human Coronavirus Infections (2020)

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has led to several million confirmed cases and hundreds of thousands of deaths worldwide. To support the ongoing research and development of COVID-19 therapeutics, this report provides an overview of protein targets and corresponding potential drug candidates with bioassay and structure-activity relationship data found in the scientific literature and patents for COVID-19 or related virus infections. Highlighted are several sets of small molecules and biologics that act on specific targets, including 3CLpro, PLpro, RdRp, S-protein-ACE2 interaction, helicase/NTPase, TMPRSS2, and furin, which are involved in the viral life cycle or in other aspects of the disease pathophysiology. We hope this report will be valuable to the ongoing drug repurposing efforts and the discovery of new therapeutics with the potential for treating COVID-19.
Role of basement inherited structural network on heat distribution and flow pathways in rift basins (2020)

Summary Deeply buried sandstone reservoirs in contact with the basement are targeted in the Upper Rhine Graben for oil, gas and geothermal energy production. Here, a conceptual basin model of fluid flow segmentation within the rift blocks, reconstructed from analytical datasets on structural network and geochemical conditions on barite and carbonate fracture infills, is tested on a 2D burial modelling approach integratin the basement structure and properties.
Performance Analysis of Multiscale Entropy for the Assessment of ECG Signal Quality (2015)

This study explored the performance of multiscale entropy (MSE) for the assessment of mobile ECG signal quality, aiming to provide a reasonable application guideline. Firstly, the MSE for the typical noises, that is, high frequency (HF) noise, low frequency (LF) noise, and power-line (PL) noise, was analyzed. The sensitivity of MSE to the signal to noise ratio (SNR) of the synthetic artificial ECG plus different noises was further investigated. The results showed that the MSE values could reflect content level of various noises contained in the ECG signals. For the synthetic ECG plus LF noise, the MSE was sensitive to SNR within higher range of scale factor. However, for the synthetic ECG plus HF noise, the MSE was sensitive to SNR within lower range of scale factor. Thus, a recommended scale factor range within 5 to 10 was given. Finally, the results were verified on the real ECG signals, which were derived from MIT-BIH Arrhythmia Database and Noise Stress Test Database. In all, MSE could effectively assess the noise level on the real ECG signals, and this study provided a valuable reference for applying MSE method to the practical signal quality assessment of mobile ECG.
The Factor IXa Second Epidermal Growth Factor (EGF2) Domain Mediates Platelet Binding and Assembly of the Factor X Activating Complex (2002)

Previously we have determined that residues 88-109 (but not Arg(94)) in the second epidermal growth factor (EGF2)-like domain of factor IXa (FIXa) are important for assembly of the factor X (FX) activating complex on phospholipid vesicles (Wilkinson, F. H., London, F. S., and Walsh, P. N. (2002) J. Biol. Chem. 277, 5725-5733). Here we report that these residues are important for platelet binding affinity, stoichiometry, and assembly of the FX activating complex. We prepared several chimeric FIXa proteins using homologous sequences from factor VII (FVII): FIXa(FVIIEGF2) (FIX Delta 88-124,inverted Delta FVII91-127), FIXa(loop1) (FIX Delta 88-99,inverted Delta FVII91-102), FIXa(loop2) (FIX Delta 95-109,inverted Delta FVII98-112), and FIXa(loop3) (FIX Delta 111-124,inverted Delta FVII114-127) and tested their ability to bind to thrombin-activated platelets. Binding affinities (K(d) values in 10(-9) m) for the proteins were as follows in the presence and absence of FVIIIa, respectively: FIXa(N) (0.55 +/- 0.06, 2.9 +/- 0.45), FIXa(WT) (0.80 +/- 0.08, 3.5 +/- 0.5), FIXa(loop1) (19 +/- 4.0, 27 +/- 5.0), FIXa(loop2) (35 +/- 9.0, 65 +/- 12.0), and FIXa(loop3) (1.1 +/- 0.09, 5.0 +/- 0.90). These K(d) values are in good agreement with K((d)(app)) values (in 10(-9) m) determined from the activation of FX (in the presence and absence of FVIIIa, respectively): FIXa(N) (0.46 +/- 0.05, 1.40 +/- 0.14), FIXa(WT) (0.72 +/- 0.08, 3.8 +/- 0.08), FIXa(loop1) (3.2 +/- 0.72, 14.0 +/- 1.60), FIXa(loop2) (18.4 +/- 1.60, 26.3 +/- 3.40), and FIXa(loop3) (0.7 +/- 0.05, 3.0 +/- 0.15). Moreover, the stoichiometry of binding (sites/platelet) showed an agreement with V(max) of FX activation and was reduced in those proteins that also showed a decreased platelet binding affinity. A peptide corresponding to the FIX EGF2 domain (Leu(84)-Val(128)) was an effective inhibitor of FIXa binding to platelets in both the presence (K(i) = 0.7 x 10(-6) m) and the absence (K(i) = 1.5 x 10(-6) m) of FVIIIa and FX. We conclude that residues 88-109 of the FIXa EGF2 domain mediate binding to platelets and assembly of the FX activating complex.ut not Ar
Intramuscular injections: a review of best practice for mental health nurses (2008)

This paper reviews practice in the area of intramuscular (IM) injection administration, an everyday activity for many nurses in clinical practice. The authors address administration of neuroleptic depot drugs within the adult mental health environment and examine the evidence base for this practice. A historical overview of injection practices and use of the dorsogluteal site is given, followed by more contemporary evidence on the benefits of using the ventrogluteal, deltoid and thigh sites. The authors point out that despite being a very commonplace nursing activity, there is a dearth of research-based guidelines for nurses in this area. A quantity of published papers and nursing texts on injection sites and techniques were assessed to evaluate their quality and relevance and their overall benefit to improving clinical practice. Much of the literature available was in the form of opinion pieces without a sound research/evidence base. There appears, however, to be enough consensual evidence to form an evidence-based clinical guideline for the administration of IM injections. The review of the available evidence, albeit at times contradictory, is presented along with a discussion of the implications for nurses.
An experience on wheelchair bank management (2008)

In this article, we described the wheelchair bank program at a local hospital and our experiences in managing the service over the past 10 years from 1996 to 2005. This article also reported statistical information related to the acquisitions of wheelchairs and adaptive components, including body support and pressure relief systems. The cost benefit of recycling seating and mobility equipments for use by children with neuromuscular diseases was revealed. With the reference of the reported data, the demands on specific types of wheelchairs and adaptive parts were disclosed to facilitate budget planning of similar services.
A single layer slotted waveguide array for 22 GHz band radio system between mobile base stations (2002)

Mobile communication has become popular and the number of base stations is growing rapidly. Planar antennas are required for a 22 GHz band wireless network which connects between a mobile base station and the central one. Three sizes of the antennas are considered for this use. The gain of the first one is (1) 33 dBi, the second one is (2) 39 dBi and the last one is (3) 45 dBi, for the 22.0-22.6 GHz and 22.6-23.2 GHz bands. A waveguide has a small transmission loss for its closed structure even at high frequency. Only a waveguide antenna can realize the subscriber radio system in such a high frequency and high gain range. However, the structure of the conventional slotted waveguide array is complicated and it has not been suitable for mass production in general. We proposed an "in-phase feed circuit" which consists of single layer /spl pi/-junctions in series and realized a simple structure and an easy manufacturing of the antennas. This paper presents a design of the antenna using resonant shunt slots; the slot design especially takes the mutual coupling into account. The antenna characteristics are confirmed by experiment in the 22 GHz band.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Power Consumption Prediction and Power-Aware Packing in Consolidated Environments (2010)

Consolidation of workloads has emerged as a key mechanism to dampen the rapidly growing energy expenditure within enterprise-scale data centers. To gainfully utilize consolidation-based techniques, we must be able to characterize the power consumption of groups of colocated applications. Such characterization is crucial for effective prediction and enforcement of appropriate limits on power consumption-power budgets-within the data center. We identify two kinds of power budgets: 1) an average budget to capture an upper bound on long-term energy consumption within that level and 2) a sustained budget to capture any restrictions on sustained draw of current above a certain threshold. Using a simple measurement infrastructure, we derive power profiles-statistical descriptions of the power consumption of applications. Based on insights gained from detailed profiling of several applications-both individual and consolidated-we develop models for predicting average and sustained power consumption of consolidated applications. We conduct an experimental evaluation of our techniques on a Xen-based server that consolidates applications drawn from a diverse pool. For a variety of consolidation scenarios, we are able to predict average power consumption within five percent error margin and sustained power within 10 percent error margin. Using prediction techniques allows us to ensure safe yet efficient system operation-in a representative case, we are able to improve the number of applications consolidated on a server from two to three (compared to existing baseline techniques) by choosing the appropriate power state that satisfies the power budgets associated with the server.
Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging (2011)

DNA methylation plays an important role in the self-renewal of hematopoietic stem cells and in the commitment to the lymphoid or myeloid lineages. Using purified CD34⁺ hematopoietic progenitor cells and differentiated myeloid cell populations from the same human samples, we obtained detailed methylation profiles at distinct stages of hematopoiesis. We identified a defined set of differentiation-related genes that are methylated in CD34⁺ hematopoietic progenitor cells but show pronounced DNA hypomethylation in monocytes and in granulocytes. In addition, by comparing hematopoietic progenitor cells from umbilical cord blood to hematopoietic progenitor cells from peripheral blood of adult donors we were also able to analyze age-related methylation changes in CD34⁺ cells. Interestingly, the methylation changes observed in older progenitor cells showed a bimodal pattern with hypomethylation of differentiation-associated genes and de novo methylation events resembling epigenetic mutations. Our results thus provide detailed insight into the methylation dynamics during differentiation and suggest that epigenetic changes contribute to hematopoietic progenitor cell aging.
Penalty-free 2.5 Gbit/s photonic switching usinga semiconductor four-gate-array module (1995)

A penalty-free photonic switching experiment at 2.5 Gbit/s using a gate-array module of four semiconductor optical amplifiers, flip-chip-mounted on a silicon motherboard and provided with high-speed electronic drivers, is reported for the first time. Switching times shorter than 400 ps are obtained, allowing for guardbands as short as two bits between consecutive cells.
Capture-Aware Estimation for the Number of RFID Tags with Lower Complexity (2013)

Capture effect is very common in wireless communication systems. In a passive radio frequency identification (RFID) system, even though multiple tags backscatter their signals to a reader simultaneously, one of the tags will be successfully identified due to the capture effect. In this letter, we propose an algorithm which will optimize the identification efficiency of a dynamic frame length ALOHA RFID protocol under capture effect. The proposed algorithm estimates the number of tags and the probability of capture effect. From these parameters, an optimal frame length can be obtained. The advantage of the algorithm is that it does not need many steps to search an extreme value for the estimation. It thus reduces the computational complexity. Computer simulation results show that the proposed method's identification efficiency is almost identical to existing algorithms, but at lower computational complexity.
A Comparison of Supervised Machine Learning Techniques for Predicting Short-Term In-Hospital Length of Stay among Diabetic Patients (2014)

Diabetes is a life-altering medical condition that affects millions of people and results in many hospitalizations per year. Consequently, predicting the length of stay of in-hospital diabetic patients has become increasingly important for staffing and resource planning. Although statistical methods have been used to predict length of stay in hospitalized patients, many powerful machine learning techniques have not yet been explored. In this paper, we compare and discuss the performance of various supervised machine learning algorithms (i.e., Multiple linear regression, support vector machines, multi-task learning, and random forests) for predicting long versus short-term length of stay of hospitalized diabetic patients.
Comparison of a Shiga Toxin Enzyme-Linked Immunosorbent Assay and Two Types of PCR for Detection of Shiga Toxin-Producing Escherichia coli in Human Stool Specimens (2003)

Shiga toxin (Stx)-producing Escherichia coli (STEC) is a major cause of sporadic cases of disease as well as serious outbreaks worldwide. The spectrum of illnesses includes mild nonbloody diarrhea, hemorrhagic colitis, and hemolytic-uremic syndrome. STEC produces one or more Stxs, which are subdivided into two major classes, Stx1 and Stx2. The ingestion of contaminated food or water, person-to-person spread, and contact with animals are the major transmission modes. The infective dose of STEC may be less than 100 organisms. Effective prevention of infection is dependent on rapid detection of the causative bacterial pathogen. In the present study, we examined 295 stool specimens for the presence of Stx-producing E. coli by three different methods: an Stx enzyme-linked immunosorbent assay, a conventional PCR assay, and a LightCycler PCR (LC-PCR) assay protocol recently developed by our laboratory at the Institute of Medical Microbiology at Hannover Medical School. Our intent was to compare these three methods and to examine the utility of the STEC LC-PCR protocol in a clinical laboratory. The addition of a control DNA to each sample to clearly discriminate inhibited specimens from negative ones enhanced the accuracy of the LC-PCR protocol. From our results, it can be concluded that LC-PCR is a very useful tool for the rapid and safe detection of STEC in clinical samples.