gebhart/patrepeval huggingface dataset:
Diagnosis and treatment of pulmonary hypertension. (2001)

Primary pulmonary hypertension is a rare disease of unknown etiology, whereas secondary pulmonary hypertension is a complication of many pulmonary, cardiac and extrathoracic conditions. Chronic obstructive pulmonary disease, left ventricular dysfunction and disorders associated with hypoxemia frequently result in pulmonary hypertension. Regardless of the etiology, unrelieved pulmonary hypertension can lead to right-sided heart failure. Signs and symptoms of pulmonary hypertension are often subtle and nonspecific. The diagnosis should be suspected in patients with increasing dyspnea on exertion and a known cause of pulmonary hypertension. Two-dimensional echocardiography with Doppler flow studies is the most useful imaging modality in patients with suspected pulmonary hypertension. If pulmonary hypertension is present, further evaluation may include assessment of oxygenation, pulmonary function testing, high-resolution computed tomography of the chest, ventilation-perfusion lung scanning and cardiac catheterization. Treatment with a continuous intravenous infusion of prostacyclin improves exercise capacity, quality of life, hemodynamics and long-term survival in patients with primary pulmonary hypertension. Management of secondary pulmonary hypertension includes correction of the underlying cause and reversal of hypoxemia. Lung transplantation remains an option for selected patients with pulmonary hypertension that does not respond to medical management.
Abstract 121: Quality of Cardiopulmonary Resuscitation by Bystanders and Survival After Out-of-Hospital Cardiac Arrest (2014)

Introduction: Although quality of cardiopulmonary resuscitation (CPR) is a key to increase survival after out-of-hospital cardiac arrest (OHCA), little is known about the quality of bystander CPR and its association with survival outcomes after OHCA. Objective: To evaluate the association of quality of bystander CPR and patient outcomes after OHCA. Methods: Designs: Population-based cohort study. Cases: All OHCA cases treated by emergency medical services (EMS) personnel in Toyonaka city between September 2011 and August 2013. Data collection and analyses: EMS personnel assessed bystanders’ CPR quality including hand position, depth, and tempo of chest compressions using a specific data form at the scene. Fleiss’ Kappa statistics was used to assess the evaluation reliability among EMS personnel and the Kappa value was 0.81 before the study. The primary outcome was patient one-month survival with favorable neurological outcome and it was compared between the good-quality CPR group and the poor-quality CPR group. Results: Among 877 cases, bystander CPR was attempted in 429 (48.9%). Data on quality of CPR was applicable in 272 (63.4%) of them. In the good-quality CPR group, bystanders were younger, more likely to be health care provider, and have experience of CPR training than in the poor-quality of CPR group. The proportion of patients with neurologically favorable one-month survival was somewhat greater in the good-quality of CPR group (4.6% versus 3.0%), although it was statistically insignificant. Conclusions: Better quality of bystander chest compressions might increase OHCA patient survival. Further efforts to improve quality of CPR by general public are needed.
Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children (2019)

Children may be the optimal target for HIV vaccine development as they generate substantially more frequent and more potent broadly HIV neutralizing antibodies (bnAbs) than adults. Development of a biomarker that correlates with neutralization breadth in this group could function as a powerful tool to facilitate the development of an HIV vaccine. Previously, we observed that this preferential ability in HIV-infected children over adults to generate bnAbs is associated with an enrichment of circulating follicular helper T-cells (T<sub>FH</sub>) with an effector phenotype, and the presence of IL-21 secreting HIV-specific T<sub>FH</sub> within lymphoid tissue germinal centers (GC). In adults, bnAbs development has been linked with high plasma levels of CXCL13, a chemoattractant for CXCR5-expressing T<sub>FH</sub> cells to the lymph node GC. We sought to test this relationship in HIV-infected children, but found no association between neutralization breadth and plasma levels of CXCL13, or with the Th2 cytokines IL-4 and IL-13, or the T<sub>FH</sub> associated factor Activin A. However, we did find an unexpected association between plasma IL-5 levels and bnAb development in these children. Importantly, although CXCL13 correlated with total circulating T<sub>FH</sub> cells, it was not associated with effector T<sub>FH</sub>. Additionally, raised CXCL13 expression was associated with a lower CD4 percentage, higher viral load and a loss of immune function, implying it is associated with progressive disease rather than HIV-specific GC activity in these subjects. Taken together, our data suggests that IL-5 should be evaluated further as a candidate plasma biomarker for HIV neutralization breadth and for monitoring vaccine responses in the pediatric age group.
Detection of NS Resource Record Based DNS Query Request Packet Traffic and SSH Dictionary Attack Activity (2009)

We carried out an entropy study on the DNS query traffic from the Internet to the top domain DNS server in a university campus network through January 1st to March 31st, 2009. The obtained results are: (1) We observed a difference for the entropy changes among the total-, the A-, and the PTR resource records (RRs) based DNS query traffic from the Internet through January 17th to February 1st, 2009. (2) We found the large NS RR based DNS query traffic including only a keyword "." in the total DNS query traffic from the Internet. (3) We also found that the unique source IP address based PTR DNS traffic entropy slightly increased, while the unique DNS query keywords based one drastically decreased in March 9th, 2009. We found a specific IP host which was an already-hijacked classical Linux PC that carried out the SSH dictionary attack to the Internet sites in March 9th, 2009. From these results, we can detect the unusual NS RR based DNS traffic and SSH dictionary attacks by only watching DNS query traffic from the Internet.
From Nonfunctional Lamellae to Functional Nanotubes (2006)

[structure: see text] Long chain alkyl-alkyl interactions appears to be the main driving force in hydrogen bond isomerism induced transformation of lamellar architectures to nanotubular constructs in alkylammonium dicarboxylate salts; the syntheses of the nanotubes require no skill for typical organic synthesis, and they are functional materials displaying intriguing gelling properties.
Disentangling the impacts of macroalgae on corals via effects on their microbiomes (2023)

Tropical reefs are commonly transitioning from coral to macroalgal dominance, but the role of macroalgae in coral decline remains inadequately understood. A growing body of research suggests that algae may harm corals via disruptions to the homeostasis of the coral holobiont, including resident microbial communities, but the processes that mediate these potential microbial effects and the spatial scales at which they operate are uncertain. Resolving the relative importance and context dependencies of microbially-mediated algal-coral competition is critical for understanding and predicting coral dynamics as reefs further degrade. In this review, we examine the current state of knowledge surrounding algal impacts on corals via disruption of their microbiomes, with a particular focus on the mechanisms hypothesized to mediate microbial effects, the scales at which they are thought to operate, and the evidence from laboratory- and field-based studies for their existence and ecological relevance in the wild. Lastly, we highlight challenges for further advancing the field.
Abstract 15681: Reduced Left Atrial Strain is Associated With the Development of Atrial Arrhythmias in Hospitalized Patients With COVID-19 (2020)

Introduction: Coronavirus Disease 2019 (COVID-19) is a pandemic with frequent cardiovascular (CV) complications, including cardiac arrhythmias. However, little is known about contributing factors to the development of new atrial tachyarrhythmias (ATs) in the inpatient setting. Left atrial strain (LAS) is a novel transthoracic echocardiography (TTE) measure of LA myocardial deformation and predicts arrhythmias. We aimed to compare clinical and echocardiographic variables including LAS in hospitalized patients with COVID-19 who developed new ATs compared to matched controls without arrhythmias. Methods: We retrospectively studied 42 patients hospitalized with COVID-19 who underwent clinical TTE. During admission, 20 patients without prior arrhythmia developed new ATs (including sustained atrial fibrillation/flutter/tachycardia, and undifferentiated supraventricular tachycardia) (cases) and were compared to 22 age and sex-matched COVID-19 patients without arrhythmias (controls). TTEs were analyzed for reservoir (peak longitudinal) LAS using 2D-speckle tracking and LA ejection fraction (LAEF) offline using TomTec software. Comparisons were made using Chi-square and t-tests as appropriate. Results: Mean age was 65±14 years, and 40% were women. There were no significant differences in CV risk factors, BMI, troponin or peak inflammatory markers between cases and controls. LAS was overall lower than normal and significantly lower in cases compared to controls (23.5±7.5% vs 31.0±6.0% respectively, P =0.001; Fig 1). There were no significant differences in left ventricular (LV) ejection fraction (LVEF), LV global longitudinal strain (GLS), LAEF, shock or death. Conclusions: COVID-19 patients who developed new ATs have lower LAS on TTE than patients without atrial arrhythmias. LAS may be a sensitive marker for identifying patients with COVID-19 at risk for ATs compared to LVEF, LV GLS, and LAEF. Larger confirmatory studies are warranted.
Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106 (2023)

The antiviral pseudo-base T705 and its de-fluoro analog T1106 mimic adenine or guanine and can be competitively incorporated into nascent RNA by viral RNA-dependent RNA polymerases. Although dispersed, single pseudo-base incorporation is mutagenic, consecutive incorporation causes polymerase stalling and chain termination. Using a template encoding single and then consecutive T1106 incorporation four nucleotides later, we obtained a cryogenic electron microscopy structure of stalled influenza A/H7N9 polymerase. This shows that the entire product-template duplex backtracks by 5 nt, bringing the singly incorporated T1106 to the +1 position, where it forms an unexpected T1106:U wobble base pair. Similar structures show that influenza B polymerase also backtracks after consecutive T1106 incorporation, regardless of whether prior single incorporation has occurred. These results give insight into the unusual mechanism of chain termination by pyrazinecarboxamide base analogs. Consecutive incorporation destabilizes the proximal end of the product-template duplex, promoting irreversible backtracking to a more energetically favorable overall configuration.
In Patients with BRCA-negative and HRD-negative Epithelial Ovarian Cancer, Should Molecular Profiling be Routinely Done to Guide Adjuvant Therapy? (2023)

In the era of targeted medicine, the use of poly (ADP-ribose) polymerase (PARP) inhibitors in homologous recombination deficient (HRD) tumors has represented the first clinically actionable mutation in gynecologic malignancies. The dramatic results seen across multiple clinical trials completely changed the landscape of epithelial ovarian cancer (EOC) treatments in both primary and recurrent settings. For many, it has spawned hope that additional biomarkers would soon be discovered that could find similarly spectacular results in different patient populations. However, molecular profiling’s efficacy in selecting targeted therapies and its economic practicality are difficult to justify.
Chord Recognition by Fitting Rescaled Chroma Vectors to Chord Templates (2011)

In this paper, we propose a simple and fast method for chord recognition in music signals. We extract a chromagram from the signal which transcribes the harmonic content of the piece over time. We introduce a set of chord templates taking into account one or more harmonics of the pitch notes of the chord and calculate a scale parameter to fit the chromagram frames to these chords templates. Several chord types (major, minor, dominant seventh, etc.) are considered. The detected chord over a frame is the one minimizing a measure of fit between the rescaled chroma vector and the chord templates. Several popular distances and divergences from the signal processing or probability fields are considered for our task. Our system is improved by some post-processing filtering that modifies the recognition criteria so as to favor time-persistence. The transcription tool is evaluated on three corpora: the Beatles corpus used for MIREX 08, a 20-audio-song corpus, and a resynthesized MIDI corpus. Our system is also compared to state-of-the-art chord recognition methods. Experimental results show that our method compares favorably to the state-of-the-art and is less computationally demanding than the other evaluated systems. Our systems entered the MIREX 2009 competition and performed very well.
Active Arrayed-Waveguide Gratings for Equalisation and WDM channel management (1999)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text A. Yiptong, M. C. Parker, and R. J. Mears, "Active Arrayed-Waveguide Gratings for Equalisation and WDM channel management," in Integrated Photonics Research, OSA Technical Digest Series (Optica Publishing Group, 1999), paper RTuJ4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Design of low side lobe subarray scannable microstrip antenna arrays at Ka-band (2002)

The paper describes the design of high performance low sidelobe, subarray scannable, circularly polarized microstrip antenna arrays for applications in point to point communications with the NASA ACT satellite (30 GHz transmit and 20 GHz receive). The radiating element and the feed structure are discussed in particular.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Polyaniline-nanotube multifunctional fiber: capabilities toward the manufacturing of smart fabric (2004)

Smart fabrics are those with electronic devices embedded in the material structure. Metallic fibres are not compatible with a comfortable fabric and flexible fibres with electronic capabilities are desired. Polyaniline (PANi) and carbon nanotubes (CNTs) show potential for application in different electronic devices such as conductive yarn, sensor, actuator, battery, capacitor and diode. The development of fibres from these materials can be considered as potentially useful for the manufacturing of smart fabric which embedded non metallic electronic devices. This paper describes the influence of CNT addition on the electronic, mechanical of PANi-CNT composite fibre which was fabricated by a wet spinning process. PANi(EB)-nanotube (SWNT, DWNT)- dimethyl propylene urea (DMPU) composite spinning solution have been prepared by an ex-situ process. The size distribution of nanotubes has been characterized by zeta sizer. Furthermore the rheological study has been conducted for optimization of PANi/CNT weight ratio to produce solutions with suitable fluidity for spinning process. In spite of the great impact of nanotubes on the mechanical and electrical properties of PANi composite fibre, the structure of the composite is far from ideal and it can be proposed that by proper ex-situ and in-situ solution preparation and processing techniques further improvements in properties are possible.
Functional specifications for collaboration services (2002)

Describes an attempt at specifying a generic and reusable set of services for computer-supported collaboration among teams engaged in any collaborative process within a distributed organization or group of organizations. The services are cataloged under the headings: information management, group communications, group management, process management, and infrastructure support.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Universal motor NN modelling (2004)

Abstract:- The paper presents a hybrid modelling of electrical motors. To improve the performance, the analytical model is combined with Adaptive-Network-based Fuzzy Inference System (ANFIS) to compensate the modelling error. The architecture and hybrid learning procedure is presented. The method is applied to universal motors. In the first step, parameters of analytical model are identified by simple least-square method. Then, the modelling error is compensated by hybrid learning procedure, preserving the meaning of the physical parameters. The reliability of the obtained model is increased. Key-Words:- Modelling, universal motor, neuronal networks 1
Meaning interventions in schools: Strategies for supporting healthy development and wellbeing in the lives of youth (2019)

Human beings inherently make meaning of the world, interpreting themselves in context and utilizing these representations to determine what to think, how to feel, and in what way to act. Developing meaning in life appears to be a highly nuanced, personal journey and yet, research suggests that those who experience their lives as meaningful enjoy multiple physical and psychological benefits and are protected from various health risks. Beyond establishing a firm sense that life is meaningful, studies suggest that people of all ages who can 'make meaning' of their experiences, especially difficult experiences, may be protected from developing some mental and physical health concerns. Childhood and adolescence may be pivotal periods for the development of this well-being resource, and school offers an especially promising context for fostering meaning. Yet, there have been few articles that have explored how meaning and meaning-making can be woven into the school day. The current article attempts to address this gap in the literature by defining meaning and meaning-making, discussing the relevance of meaning from a developmental framework, and offering suggestions for applications for teachers and providers during the school day.
Determination of cholesterol and cholesterol ester with novel enzyme microsensors (1993)

Enzyme microsensors using cholesterol oxidase (EC 1.1.3.6) and cholesterol esterase (EC 3.1.1.13) were developed for measuring cholesterol and cholesterol ester. The platinum microsensors (platinum diameter, 50 microns) were etched in hot aqua regia to create a cavity at their tip. A porous composite material prepared from acetylene black and Teflon emulsion was packed into this cavity and the redox mediator [Os(bpy)3](PF6)2 was monitored by cyclic voltammetry in the potential range of 200-900 mV. The microsensors were dipped overnight in buffer solution containing the desired enzyme to immobilize it on the tip by adsorption. Calibration curves for measurements of cholesterol and cholesterol ester, the effects of pH, temperature, and concomitant compounds, the lifetime of the microsensors, and their availability for measuring cholesterol and cholesterol ester in urine were examined. Under optimal conditions, the response of the sensors was linear in concentration ranges of 5 microM-0.47 mM cholesterol and 2 microM-1.00 mM cholesterol ester.
Pharmacology of Acorus calamus L. (1989)

Water soluble dried powder of alcoholic extract of roots and rhizomes of A. calamus L. was used. The in vivo experiments involved strychnine convulsant activity in frogs, spontaneous motor activity and amphetamine hyperactivity in mice, pentobarbitone sleeping-time in rats and local anaesthetic activity in guinea pigs and rabbits. Frog skeletal muscle and heart preparations and rat phrenic nerve diaphragm constituted the in vitro experiments. Plant extracts at 10, 20 mg/kg ip did not afford protection to strychnine (1,5,2.5 mg/kg) induced convulsions and same effect was found on acetylcholine induced contractions of rectus muscle except that it inhibited caffeine citrate contractions in frog. At 1, 10 and 100 micrograms/ml doses, it caused negative iono- and chronotropic effects in frogs. Dosages of 10, 25, 50 mg/kg ip of herbal extract antagonize spontaneous motor activity and also amphetamine induced hyperactivity in mice. It was less potent than chloropromazine, though exerts sedative and tranquilizing action. Local anaesthetic activity was found to be absent at 0.5 and 1% dose levels.
Design and Implementation of Dimmable Electronic Ballast Based on Integrated Inductor (2007)

This paper presents an implementation of integrated inductor for typical dimmable electronic ballasts having two power processing stages. The inductor used in the front-stage power factor corrector is integrated with the resonant inductor in the output-stage of the ballast inverter, so that the usage of the magnetic core material, and thus the cost, can be reduced. Existing circuit schematic can be retained without requiring any modification. Most importantly, the ballast performance is similar to the original design with two separate inductors. Based on using a z-parameter gyrator-capacitor model, modeling, design, and analysis of the ballast operation will be presented. A comparative study of using two separate inductors and integrated-inductor designs on the core volume, conduction and hysteresis losses, inductor current waveforms, input current harmonics, output lamp crest factor, overall efficiency, and costing will be carried out. Simplified design procedures will be given. The structure has been successfully applied to a 36-W prototype
Enhancement of chemical carcinogenesis in mice by systemic effects of ultraviolet irradiation. (1988)

The present study was designed to determine the systemic influence of ultraviolet (UVB) irradiation upon subsequent carcinogenesis induced by benzo(a)pyrene. The source of UV irradiation consisted of six Westinghouse FS-40 fluorescent sunlamps. Female BALB/c mice received five 30-min dorsal UVB radiation treatments per week for 13 wk. At the end of 13 wk, irradiated and unirradiated mice received ventral applications of 0.1 or 1.0 mg of benzo(a)pyrene twice weekly for 20 or 10 wk, respectively. At 18 wk after the first benzo(a)pyrene treatment, mice receiving 0-, 0.1-, or 1.0-mg benzo(a)pyrene treatments bore 0, 12, or 29 tumors per group of 18 mice, respectively. Tumor-free survival was significantly shortened in the UV-irradiated hosts as compared with unirradiated hosts, as analyzed by the Kaplan-Meier method of survival analysis. Therefore, ultraviolet irradiation induced a systemic effect which enhanced subsequent tumor induction by benzo(a)pyrene in a manner which was dependent on the dose of benzo(a)pyrene.
AN2: A High-Performance ATM Switch (1995)

This paper is a draft of a technical report that was never published. AN2 is a high-performance Asynchronous Transfer Mode (ATM) switch developed at Digital’s Systems Research Center. AN2 provides sixteen 800 Mbit/sec. porls, each of which can contain a 4-port 155 Mbitlsec (Oe·3) line card, or a single 622 Mbit/sec. (OC12) line card. AN2 supports both constant bit rate (CBR) and available bit rate (ABR) traffic. It uses a unique hop-by-hop flow contra] prolocollhal eliminates cell loss. even in the presence of congestion. Software in the switch provides circuit setup functions, automatic network reconfiguration in the event of hardware failures, and resilient virtual circuits, which provide automatically-established connections in a local area ATM network of modest size. AN2 is the prototype for Digital’s ATM switch products. In this paper, we discuss the implementation of the hardware and software of AN2.