gebhart/patrepeval huggingface dataset:
Distribution and antitumor activity of adriamycin given in a high-dose and a repeated low-dose schedule to mice. (1978)

Experimental studies on the distribution of adriamycin (AM) under different treatment conditions and possible correlations between tissue and plasma levels and chemotherapeutic activity are discussed. C57BL/6J mice bearing im Lewis lung carcinoma and (C3H x O2O)F1 mice bearing mammary carcinoma were injected iv with AM at a single dose of 15 mg/kg or with the same total amount of drug administered in spaced doses of 3.75 mg/kg for 4 consecutive days. In the two experimental systems studied, the drug reached approximately the same value in the tumor and spleen with both types of treatment, but with the 3.75-mg/kg x 4 schedule much lower AM concentrations were observed in the heart than with the single high-dose treatment. The therapeutic activity of the two treatments also differed: the antitumor and antimetastatic effect was the same in the two tumor systems, but with the 3.75-mg/kg x 4 schedule, increased survival and somewhat lower toxicity were observed. Daunorubicin, tested in the mammary carcinoma system with the two schedules of treatment, behaves very similarly to AM in terms of both distribution and chemotherapeutic effect.
The Need for a Borehole Disposal Field Test for Operations and Emplacement. (2022)

Abstract not provided.
Conformational Transitions of Calixphyrin Derivatives Monitored by Temperature-Dependent NMR Spectroscopy. Ab Initio Interpretation of the Spectra (2005)

Eight meso-aryl calixphyrin derivatives were synthesized and their conformational equilibria and transitions studied with temperature-dependent NMR spectroscopy. On the basis of density functional computations, several conformer species could be identified and observed changes in chemical shifts explained. In some compounds, the aryl group rotation and porphyrin ring flipping could be monitored independently, as their NMR coalescence temperatures were well-separated. Calculated relative conformer energies, transition barriers, and isotropic shieldings agree well with the experimental data. In the meso-substituted porhyrins (calixphyrins) the sp3 carbon atoms perturb their pi-electron system and significantly modify the molecular shape and the flexibility. Even when the conjugation of the pi-electron system was destroyed by the nonplanarity, far-range electronic induction effects still exist and influence chemical shielding and molecular geometry. The aryl functional groups moderately modify the structure of the calixphyrin ring and thus can be used for fine-tuning of the mechanical and chemical properties of these compounds.
The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4 (2010)

Subungual exostosis is a benign bone- and cartilage-forming tumor known to harbor a pathognomonic t(X;6)(q22;q13-14). Using global gene expression analysis and quantitative real-time PCR, we could show that this translocation results in increased expression of the IRS4 gene, presumably due to disruption and/or exchange of regulatory sequences with the translocation partner, the COL12A1 gene. A corresponding deregulation at the protein level could be demonstrated in primary cell cultures using a combination of fluorescence in situ hybridization and immunostaining. As the t(X;6) usually is the sole cytogenetic aberration in subungual exostosis, the deregulated expression of IRS4 is likely to be pathogenetically essential. The exact role of IRS4 is still poorly investigated, but IRS proteins are known to act as mediators of signaling from receptors, such as the insulin and insulin-like growth factor 1 receptors, and thus have an important effect on cell growth and survival.
Virus Particles in Early Mouse Embryos2 (1973)

Electron microscope observations of 2-celled embryos from 8 strains of laboratory mice revealed an abundance of intracisternally located type-A particles. A much smaller number of the same type particle was seen in blastocysts from the same strains. Blastocysts and egg cylinders from highly leukemo-genic AKR mice also contained budding and extracellularly located type-C particles. Unfertilized eggs of all strains investigatedl acked any visible viral particles.
Upregulation of Neurotrophic Factors Selectively in Frontal Cortex in Response to Olfactory Discrimination Learning (2007)

We have previously shown that olfactory discrimination learning is accompanied by several forms of long-term enhancement in synaptic connections between layer II pyramidal neurons selectively in the piriform cortex. This study sought to examine whether the previously demonstrated olfactory-learning-task-induced modifications are preceded by suitable changes in the expression of mRNA for neurotrophic factors and in which brain areas this occurs. Rats were trained to discriminate positive cues in pair of odors for a water reward. The relationship between the learning task and local levels of mRNA for brain-derived neurotrophic factor, tyrosine kinase B, nerve growth factor, and neurotrophin-3 in the frontal cortex, hippocampal subregions, and other regions were assessed 24 hours post olfactory learning. The olfactory discrimination learning activated production of endogenous neurotrophic factors and induced their signal transduction in the frontal cortex, but not in other brain areas. These findings suggest that different brain areas may be preferentially involved in different learning/memory tasks.
Design and Implementation of an FMCW Radar Signal Processing Module for Automotive Applications (2016)

In the recent years, the radar technology, once used predominantly in the military, has started to emerge in numerous civilian applications. One of the areas that this technology appeared is the automotive industry. Nowadays, we can find various radars in modern cars that are used to assist a driver to ensure a safe drive and increase the quality of the driving experience. The future of the automotive industry promises to offer a fully autonomous car which is able to drive itself without any driver assistance. These vehicles will require powerful radar sensors that can provide precise information about the surrounding of the vehicle. These sensors will also need a computing platform that can ensure real-time processing of the received signals. 
The subject of this thesis is to investigate the processing platforms for the real-time signal processing of the automotive FMCW radar developed at the NXP Semiconductors. The radar sensor is designed to be used in the self-driving vehicles.
The thesis first investigates the signal processing algorithm for the MIMO FMCW radar. It is found that the signal processing consists of the three-dimensional FFT processing. Taking into account the algorithm and the real-time requirements of the application, the processing capability of the Starburst MPSoC, 32 core real-time multiprocessor system developed at the University of Twente, has been evaluated as a base-band processor for the signal processing. It was found that the multiprocessor system is not capable to meet the real-time constraints of the application. 
As an alternative processing platform, an FPGA implementation of the algorithm was proposed and implemented in the Virtex-6 FPGA. The implementations uses pre-built Xilinx IP cores as hardware components to build the architecture. The architecture also includes a MicroBlaze core which is used to generate the artificial input data for the algorithm and manage the operation of hardware components through software. 
The results of the implementation show that the architecture can provide reliable outputs regarding the range, velocity and bearing information. The accuracy of the results are limited by the range, velocity and angular resolution which are determined by the specific parameters of the RF front-end and the designed waveform pattern. However, the real-time performance on the architecture cannot be achieved due to the high latencies introduced by the memory transpose operations. A few techniques have been tested to decrease the latency bottleneck caused by the SDRAM transpose processes, however none of them have shown any significant improvements.
Microstructural order in the developing cotton fiber based on availabilities of hydroxyl groups (1985)

Abstract The relative availabilities of accessible O(2)H, O(3)H, and O(6)H in the cellulose of developing cotton fibers were measured by conducting a reaction to a low degree of substitution under mild conditions in an aqueous medium. Raw cotton fibers from unopened bolls and from mature, opened bolls were studied. Correction was made for the presence of a β‐1,3‐glucan that was detected by substitution at the abundant O(4)H of this polysaccharide. The order of decreasing availability of hydroxyl groups of cellulose was O(2)H &gt; O(6)H &gt; &gt; O(3)H. Results indicate that cellulose in the secondary wall of the cotton fiber is laid down with a high degree of order and that this order decreases with opening of the boll.
DNA sequence organization in the lepidopteran Antheraea pernyi. (1976)

A large fraction of the genome of the lepidopteran Antheraea pernyi consists of interspersed single-copy sequences and repetitive DNA sequences of 300 nucleotide average length. Most of the single-copy sequences are about 800 nucleotides long and a minority are considerably longer. Thus, the organization of the DNA sequences of this insect is similar to that of most higher organisms and different from that of Drosophila.
The Use of Low Molecular Weight Heparins in the Prevention of Venous Thromboembolic Disease (1998)

Deep vein thrombosis (DVT) and pulmonary embolism (PE) are leading causes of morbidity and mortality in the United States. Estimates range between 300,000 and 600,000 hospitalizations a year, with approximately 50,000 deaths related to PE. The incidence of the complication of DVT following total joint replacement is reported to occur in 50% to 75% of all unprotected patients. The increasing number of adults who undergo a total joint replacement dictates that orthopaedic nurses become a vital part of the development team that (1) identifies contributing factors to each patient's risk profile, (2) decreases this risk, and (3) refines the patient's transition through the acute hospitalization into the home or rehabilitation environment. The results of recent studies with a new class of heparins, the low molecular weight heparins, suggest their superiority and demonstrate improvement in decreasing the risk of developing DVT and subsequent PE in the total hip and knee patient population.
Kinematic problems of manipulators for minimal invasive surgery. (1993)

The article discusses handling problems in endoscopic surgery and concepts for the augmentation of instrument dexterity. The authors present a kinematic concept for improved surgical tool positioning and orientation. Using a trunk mechanism it is possible to assure augmented dexterity and stiffness for endoscopic handling. The paper addresses the use of steerable endoscopic instruments in a manipulator system for minimal invasive surgery.
Consolidation Chemotherapy Prevents Relapse by Indirectly Regulating Bone Marrow Adipogenesis in Patients with Acute Myeloid Leukemia (2018)

Chemotherapy indirectly inhibited adipogenesis by promoting GDF15 secretion from BM MNCs, subsequently strengthening the efficacy of consolidation chemotherapy in patients with AML during CR.
EFFECT OF POSTMORTEM AGING AND HYDRODYNAMIC PRESSURE PROCESSING ON PORK LOIN QUALITY (2010)

ABSTRACT The objective of this study was to determine the influence of hydrodynamic pressure processing (HDP) and aging on the overall quality and protein characteristics of pork loins. Boneless pork loins ( n = 12) were split into anterior and posterior halves and were assigned to control and HDP treatments. Following treatment on day 0, each half was divided into two portions (0 and 7 days aging). Samples were removed for the determination of Warner–Bratzler shear force (WBSF), centrifugal moisture loss (CML), gravitational drip loss (DL), color, protein solubility and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS‐PAGE) analysis of whole muscle protein extracts. WBSF decreased with HDP ( P &lt; 0.05) and aging treatments ( P &lt; 0.0001). CML decreased ( P &lt; 0.0001) with aging. Controls exhibited slightly less DL after 1 day than HDP samples, but the increase in DL between 1 and 7 days was similar for control and HDP samples. Treatment effects on L *, a * and b * measurements were minimal. Myofibrillar and total protein solubility were higher ( P &lt; 0.01) in HDP samples compared with controls at day 0 but not at day 7. Sarcoplasmic protein solubility decreased ( P &lt; 0.05) with aging. SDS‐PAGE analysis of muscle proteins demonstrated a strong aging effect and only minor HDP differences. With aging, bands corresponding to 30–33 and 135 kDa increased ( P &lt; 0.0001), while bands corresponding to 38 and 95 kDa decreased ( P &lt; 0.05) in intensity (relative to the actin band). The 60 kDa band intensity increased ( P &lt; 0.05) with both aging and HDP treatments. Thus, data from this study suggest that HDP enhances aging tenderization in pork loins through the physical disruption of the muscle ultrastructure while having little detrimental effect on other parameters of pork quality. PRACTICAL APPLICATIONS This study demonstrates that hydrodynamic pressure processing is an effective postharvest technology for enhancing aging tenderization in pork loins through the physical disruption of the muscle ultrastructure with minimal impacts on other pork quality parameters such as water‐holding capacity and color.
Dicarboxylic acids from ozonolysis of cycloalkenes (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDicarboxylic acids from ozonolysis of cycloalkenesRamzi M. Habib, Chin Yun Chiang, and Philip S. BaileyCite this: J. Org. Chem. 1984, 49, 15, 2780–2784Publication Date (Print):July 1, 1984Publication History Published online1 May 2002Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/jo00189a026https://doi.org/10.1021/jo00189a026research-articleACS PublicationsRequest reuse permissionsArticle Views866Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An application-oriented error control scheme for high-speed networks (1996)

Many new network applications demand interprocess communication (IPC) services that are not supported by existing transport protocol mechanisms. Large bandwidth-delay products of high-speed networks also render some of the existing error and flow control mechanisms less efficient. In particular, new error control schemes that can provide variable degrees of error recovery according to the application's requirements are desirable. This paper presents the design, evaluation, and implementation of an application-oriented error control-scheme that is aimed at supporting efficient IPC in high-speed networking environments. Our results indicate that the proposed error control scheme allows effective control of the trade-off between the amount of error an application can tolerate and the amount of delay it has to suffer.
Regulation of the G1 → S phase transition in chick embryo fibroblasts with α‐keto acids and L‐alanine (1979)

Temporal inhibition of protein synthesis with cycloheximide prevents subsequent insulin, but not serum-stimulated DNA synthesis in G1-arrested chick embryo fibroblasts (CEF). The inhibition is measured by the incorporation of 3H-thymidine into acid insoluble material and confirmed by chemical estimate of the DNA content of inhibited and uninhibited cells. Cycloheximide treatment is without effect if the cell cultures are maintained at 4 degrees C while exposed to the drug. Several alpha-keto acids (pyruvate, oxaloacetate, alpha-ketobutyrate) at 0.5-1 mM concentrations restore DNA synthesis in previously inhibited cells when combined with insulin. L-alanine (D-alanine is inert) is even more effective than the keto acids in stimulating DNA synthesis after cycloheximide treatment. Glucose transport was unaffected by cycloheximide treatment while lactate levels in medium from inhibited, insulin-stimulated CEF were reduced 70% compared to uninhibited counterparts. We speculate that cycloheximide treatment may lead to the decay of a glycolytic enzyme which compromises the ability of inhibited cells to synthesize pyruvate from glucose, and thus induces an exogenous requirement for alpha-keto acid or L-alanine. A serum component(s) with a molecular weight of about 100 permitted insulin-stimulated DNA synthesis in inhibited cells.
Proactive Retransmission in Delay-/Disruption-Tolerant Networking for Reliable Deep-Space Vehicle Communications (2018)

Delay-/disruption-tolerant networking is recognized by the National Aeronautics and Space Administration as the only candidate network communication technology that approaches the level of maturity required for deep-space vehicle communications. Extensive performance evaluation and development of efficient data transmission mechanisms for its main protocol, bundle protocol (BP), are needed. In this paper, a new transmission approach based on “proactive” retransmission is proposed for BP for highly efficient data delivery in deep-space communications characterized by a high rate of data loss, long signal propagation delay, and highly asymmetric channel rate, given ample transmission bandwidth. The objective is to ensure successful and reliable deep-space file transfer within a single communication round-trip interval. The expected total number of transmission attempts needed for successful delivery of a file is first calculated based on the available space channel quality and the configured bundle size. Then, the time-out interval for custodial retransmission is set according to the expected number of transmission attempts required, such that all these attempts will be undertaken within the interval of a single round-trip. The performance evaluations based on both theoretical modeling and file transfer experiments indicate that the proposed proactive retransmission approach achieves the objective and has significant performance advantages over the existing reactive retransmission regardless of the transmission conditions.
A Hierarchical Model-based Predictive Control Strategy for Building Heating Systems (2014)

A hierarchical Model Predictive Control (MPC) strategy for optimally controlling the heating system of a building is developed to satisfy comfort constraints with reduced energy consumption. MPC based strategies can prevent unnecessary energy use by predicting the future heating requirement of the building and only supplying heat when necessary. In this paper, prediction error estimation methods are used to derive reduced order building models from historical data. A hierarchical structure is implemented, with interior-point algorithms employed to solve the resulting optimization problems. A simulation platform, designed to replicate the thermal dynamics and the heating system mechanisms of a real building is used to test the strategy. The MPC formulation is compared to the standard weather compensation scheme used in the building on which the simulation platform is based.
The Sagnac effect: correct and incorrect explanations (2000)

AE 1. AE (1325). 2. (1326). 2.1. . 2.2. . 2.3. AE AE - AE. 2.4. . 3. (1334). 3.1. AE , AE . 3.2. - AE AE AE . 3.3. AE AE-
Detection of clinical vancomycin‐resistant enterococci in Denmark by multiplex PCR and sandwich hybridization (1999)

Since the first cases of human infection with vancomycin-resistant enterococci (VRE) were reported in the late eighties, there has been a dramatic increase in VRE all over the world. So far, there have not been any reports of clinical VRE in Denmark. In this study we have investigated 131 clinically important enterococci sent to Statens Serum Institut from all over Denmark during the period July 1995 to May 1997. The susceptibility to vancomycin, teicoplanin, ampicillin and gentamicin was tested by the agar dilution method. In addition, two methods were developed to detect the different genotypes of glycopeptide resistance described in enterococci: a multiplex PCR assay for detection of vanA, vanB, vanC-1, vanC-2/3 ligase genes including 16S rRNA gene control primers and a sandwich hybridization assay to confirm vanA and vanB PCR-positive strains. The highest frequency of resistance to the tested antibiotics was found in the Enterococcus faecium group. Four strains were found with acquired resistance to glycopeptides: one E. faecium and one E. gallinarum were vanA positive, and two E. faecium isolates were vanB positive. These strains were isolated from different hospitals in different periods of time, and all patients recovered from their infections with VRE. Today, the PCR and sandwich hybridization methods are used for screening of vancomycin-resistant enterococci in humans as part of the Danish surveillance programme.
Lesiones medulares catastróficas en el rugby argentino. Impacto de las medidas implementadas y su reducción relativa en el tiempo (2021)

Introducción: Se entiende por lesión catastrófica a cualquier trauma grave que comprometa la cabeza, el cerebro, la columna vertebral o la médula espinal, que pone en riesgo la vida o puede dejar una discapacidad permanente o semipermanente. En la Argentina, la incidencia de lesionados en el ámbito del rugby es alta comparada con la de otros países. En los últimos años, se han implementado múltiples medidas de prevención y se han modificado normas con el objetivo de evitar las lesiones catastróficas. Materiales y Métodos: Se analizaron datos obtenidos de una encuesta telefónica realizada en el marco de colaboración entre la Unión Argentina de Rugby y la Fundación para la Lucha de Enfermedades Neurológicas de la Infancia (Fleni). Se realizó un análisis descriptivo de los datos. Se recopilaron los cambios en las normativas del deporte, que pudieran tener impacto en las futuras lesiones. Resultados: Se observa que el número de lesiones se mantiene estable año tras año. Al asociar este dato con un aumento sostenido de la cantidad de jugadores por año, impresiona haber una disminución relativa del riesgo de lesionarse. Conclusiones: Las lesiones catastróficas generan un gran impacto en la calidad de vida del jugador y de su entorno. Deben considerarse inadmisibles y se deben incrementar los esfuerzos para lograr eliminar los riesgos de lesionarse. El esfuerzo de las entidades reguladoras impresiona tener un impacto positivo al haberse logrado una reducción relativa de las lesiones en relación con el aumento de jugadores año tras año.
Amyloid Structures at the Atomic Level: Insights from Crystallography (2013)

This chapter contains sections titled: Atomic Structures of Segments of Amyloid-Forming Proteins Stability of Amyloid Fibers Which Proteins Enter the Amyloid State? Molecular Basis of Amyloid Polymorphism and Prion Strains Atomic Structures of Steric Zippers Suggest Models for Amyloid Fibers of Parent Proteins Atomic Structures of Steric Zippers Offer Approaches for Chemical Interventions against Amyloid Formation Summary Acknowledgments References