gebhart/patrepeval huggingface dataset:
Antiemese: Die Neuerungen der ASCO-Guideline im Überblick (2021)

&lt;b&gt;Purpose:&lt;/b&gt; To update the guideline to include new anticancer agents, antiemetics, and antiemetic regimens and to provide recommendations on the use of dexamethasone as a prophylactic antiemetic in patients receiving checkpoint inhibitors (CPIs). &lt;b&gt;Methods:&lt;/b&gt; ASCO convened an Expert Panel and updated the systematic review to include randomized controlled trials (RCTs) and meta-analyses of RCTs published between June 1, 2016, and January 24, 2020. To address the dexamethasone and CPI question, we conducted a systematic review of RCTs that evaluated the addition of a CPI to chemotherapy. &lt;b&gt;Results:&lt;/b&gt; The systematic reviews included 3 publications from the updated search and 10 publications on CPIs. Two phase III trials in adult patients with non–small-cell lung cancers evaluating a platinum-based doublet with or without the programmed death 1 (PD-1) inhibitor pembrolizumab recommended that all patients receive dexamethasone as a component of the prophylactic antiemetic regimen. In both studies, superior outcomes were noted in the PD-1 inhibitor–containing arms. Other important findings address olanzapine in adults and fosaprepitant in pediatric patients. &lt;b&gt;Recommendations:&lt;/b&gt; Recommendations for adults are unchanged with the exception of the option of adding olanzapine in the setting of hematopoietic stem cell transplantation. Dosing information now includes the option of a 5-mg dose of olanzapine in adults and intravenous formulations of aprepitant and netupitant-palonosetron. The option of fosaprepitant is added to pediatric recommendations. There is no clinical evidence to warrant omission of dexamethasone from guideline-compliant prophylactic antiemetic regimens when CPIs are administered to adults in combination with chemotherapy. CPIs administered alone or in combination with another CPI do not require the routine use of a prophylactic antiemetic. Additional information is available at www.asco.org/supportive-care-guidelines.
CALENDAR OF EVENTS (2008)

Neurosurgery: January 2008 - Volume 62 - Issue 1 - p E264-E267 doi: 10.1227/01.NEU.0000311092.57379.D2
Silicon Gate Oxide Thickness Uniformity during HCl Oxidation (1991)

Systematic oxide thickness variations across individual wafer surfaces, as well as from wafer to wafer within quartz boats were observed during oxidation. These variations, namely, a radial oxide thinning toward the wafer center and a wafer spacing dependence of average oxide thickness, were associated with the use of during "dry" gate oxidation. The "bull's eye" thickness profile amounted to a 5% variation in a 25.0 nm gate oxide for densely packed (5 mm spacing) wafers. The radial variation disappeared when wafers were spaced far apart (50 mm). The oxide thickness variation was quantitatively correlated to the amount of chlorine incorporated in the oxide where the chlorine content was found to be linearly proportional to the oxide thickness. This oxidation nonuniformity could be modeled by the radial depletion of an active intermediate, chlorine‐containing species during oxidation. While oxides grown in or , did not exhibit a radial thickness variation, those grown in did exhibit thickness variations similar to oxidations. The absolute enhancement of the oxidation rate due to the additions of , , , or in an otherwise dry oxidation was also studied, with alone and alone producing a large enhancement in growth rate (35% thicker oxide for 2.25% or 4.5% additions). The enhancement due to addition was more modest (15% for 2.5% addition). Transients during the switchover in gases, e.g., from during loading to for oxidation, apparently did not play a major role in causing the observed nonuniformities. The use of thick‐oxide "dummy" wafers, grown in a hydrogen‐ or chlorine‐containing atmosphere, between bare silicon wafers had a profound effect on improving thickness uniformity. The oxide thickness variation was reduced when wafers with 0.4 μm dry oxides were interspersed between growing gate oxides; however, this improved oxide uniformity was attributed to a larger spacing between oxidizing wafers. Surprisingly however, variations completely disappeared when the dummy wafers were grown in steam, dry , or dry , suggesting that these dummy wafers play an active role in enhancing the supply of reactive intermediates to adjacent wafers.
Supplementary Table S2 from Ductal Carcinoma <i>In situ</i> and the Emergence of Diversity during Breast Cancer Evolution (2023)

Supplementary Table S2 from Ductal Carcinoma &lt;i&gt;In situ&lt;/i&gt; and the Emergence of Diversity during Breast Cancer Evolution
Effects of Rare Earth Added to Sulfamate Solution on the Microstructure and Properties of Electroformed Layers (2006)

The effects of rare earth LaCl_3 added to the basic sulfamate solution on electrolyte characteristic and microstructure and properties of electroformed nickel layers were studied.The action mechanism of LaCl_3 on the surface of cathodic electrode was discussed.It has been found that the cathodic polarization of the electrodepositing process is increased due to occurring of LaCl_3 special adsorption on electrode surface,which could result in crystal refining of electroformed layers.Moreover,the crystal orientation has strong (111 ) texture,and the micro-hardness could be improved substantially with the addition of LaCl_3.
Medium-Term Outcome in Patients Treated with Total Hip Arthroplasty Using a Modular Femoral Stem (2012)

The clinical, radiographic and quality of life results of total hip arthroplasty using the MODULUS cementless modular femoral stem were reviewed. 48 patients who had a total hip arthroplasty using the MODULUS femoral stem were identified. Six had bilateral procedures, resulting in 60 hips with complete clinical and radiographic data. Mean age at implantation was 50 years (range 33 to 82). Mean follow-up was 59 months (range 50 months to 73). There were two early post-operative dislocations (within 2 days). One patient required further surgery to remove heterotopic bone. Mean Harris Hip Score increased from 37 points preoperatively (range, 7 to 66) to 89 points at final review (range, 65 to 100 points). Radiographic evaluation revealed that all implants were stable without evidence of osteolysis but three patients (5%) exhibited heterotopic ossification. Quality of life was evaluated with the SF36. The physical component increased from 29.2 points (range, 18.5 to 46.0) to 51.7 points (range 42.9 to 60.6) and the mental component from 375 points (range, 19.5 to 50.0) to 50 points (range 32,8 to 62.0).
Performance Pentagon: Five Strategies to Help All Students Make the Grade (2001)

A review of current literature and practice suggests promising alternatives to social promotion and grade retention. The following five alternative strategies, which strike at the root causes of poor performance, offer genuine hope for helping all students to succeed: Intensify learning, provide professional development to ensure skilled teachers, expand learning options, assess students in a manner to assist teachers, and intervene in time to arrest poor performance.
An $E$ -Band Power Amplifier With 26.3% PAE and 24-GHz Bandwidth in 22-nm FinFET CMOS (2019)

This paper presents the design and optimization of an E-band power amplifier (PA) implemented in Intel's 22FFL FinFET process. Layout optimization and characterization of the PA unit cell yielding optimal millimeter-wave (mmW) performance of the active device are described. A holistic optimization methodology is also presented which co-optimizes efficiency of the active devices and passive networks by incorporating passive losses earlier in the design process. The measured PA achieves a peak gain of 18.6 dB with a 3-dB bandwidth of 62-86 GHz (24 GHz). At 75 GHz, the measured Psat, OP1 dB, and peak power added efficiency (PAE) are +12.6 dBm, +5.7 dBm, and 26.3%, respectively. The PA can amplify a 6-Gb/s 16-QAM signal at an average Pout of +5 dBm with a PAE of 10% and -26-dB EVM(rms) and a 9-Gb/s 64-QAM signal at an average Pout of +1.3 dBm with a PAE of 5% and -28.3-dB EVM(rms). The compact layout of the PA yields a core area of 0.054 mm2, enabling compact integration.
The Son of the Sheik (2011)

Ahmed s'enamora d'una ballarina a la que rapta i viola. Posteriorment la salva d'una banda de renegats.
Lysosomal Targeting of Epidermal Growth Factor Receptors via a Kinase-dependent Pathway Is Mediated by the Receptor Carboxyl-terminal Residues 1022-1123 (1996)

Binding of epidermal growth factor (EGF) to its receptor induces rapid internalization and degradation of both ligand and receptor via the lysosomal pathway. To study the mechanism of intracellular sorting of EGF-EGF receptor complexes to lysosomes, NIH 3T3 cells transfected with wild-type and mutant EGF receptors were employed. The kinetics of 125I-EGF trafficking was analyzed using low concentrations of the ligand to avoid saturation of the specific sorting system. The relative size of the pool of internalized 125I-EGF-receptor complexes that were capable of recycling decreased as receptors traversed the endosomal system. The rate of 125I-EGF sequestration from the recycling pathway correlated with the rate of 125I-EGF transition from early to late endosomes as measured by Percoll gradient fractionation. Deletion of the last 63 amino acids of the EGF receptor cytoplasmic tail did not inhibit the process of sequestration and targeting to the late endosomes and lysosomes. Truncation of the 123 residues, however, resulted in impaired lysosomal targeting and increased recycling of EGF. Receptor mutant in which 165 residues were deleted displayed maximal ability to recycle and a minimal extent of sorting to the late endosomes. The data suggest that two regions of the EGF receptor molecule, residues 1022-1063 and to a lesser extent residues 1063-1123, contribute in the regulation of routing of EGF receptors to the degradation pathway. The kinase-negative receptor mutant recycled EGF more intensively compared with the wild-type receptor, and the transport of this mutant to late endosomes was inhibited. These results support the view that the receptor kinase activity is important for ligand-induced sorting of EGF receptors to the pathway of lysosomal degradation.
Clinical Applications of Pluripotent Stem Cells and Their Derivatives: Current Status and Future Perspectives (2022)

Pluripotent stem cells (PSCs) can differentiate into specific cell types and thus hold great promise in regenerative medicine to treat certain diseases. Hence, several studies have been performed harnessing their salutary properties in regenerative medicine. Despite several challenges associated with the clinical applications of PSCs, worldwide efforts are harnessing their potential in the regeneration of damaged tissues. Several clinical trials have been performed using PSCs or their derivatives. However, the delay in publishing the data obtained in the trials has led to a lack of awareness about their outcomes, resulting in apprehension about cellular therapies. Here, the authors review the published papers containing data from recent clinical trials done with PSCs. PSC-derived extracellular vesicles hold great potential in regenerative therapy. Since published papers containing the data obtained in clinical trials on PSC-derived extracellular vesicles are not available yet, the authors have reviewed some of the pre-clinical work done with them.
Hydroxyapatites and Europium(III) Doped Hydroxyapatites as a Carrier of Silver Nanoparticles and Their Antimicrobial Activity (2012)

Hydroxyapatites (Ca10(PO4)6(OH)2 and Eu3+:Ca10(PO4)6(OH)2) were synthesized by aqueous synthesis route. Hydroxyapatites were impregnated with silver ions that were subsequently reduced. XRD, TEM, and SAED measurements were used in order to determine the crystal structure and morphology of the final products. The results showed the well crystallized hydroxyapatite grains with diameter of about 35 nm and with silver nanoparticles on their surface. The antimicrobial activity of the nanoparticles against: Staphylococcus aureus ATCC 6538 as model of the Gram-positive bacteria, Escherichia coli ATCC 11229, and Klebsiella pneumoniae ATCC 4352 as model of Gram-negative bacteria, were shown with the best activity against K. pneumoniae. These nanocomposite powders can be a promising antimicrobial agent and a fluorescent material for biodetection due to their optical and bioactive properties.
The Asymptotic Expansion of the Generalised Hypergeometric Function (1952)

P. 287, LEMMA, line 3, for Am read kAmj line 5, for k½−9 read k−½−9. I am indebted to Dr. E. C. Bullard for drawing my attention to this error.
Discrimination of the SARS–CoV-2 strains using of coloured s-LASCA-imaging of GB-speckles, developed for the gene “S” nucleotide sequences (2021)

<ns3:p> <ns3:bold>Background</ns3:bold> : A recent bioinformatics technique involves changing nucleotide sequences into 2D speckles. This technique produces speckles called GB-speckles (Gene Based speckles). All classical strategies of speckle-optics, namely speckle-interferometry, subtraction of speckle-images as well as speckle-correlometry have been inferred for processing of GB-speckles. This indicates the considerable improvement in the present tools of bioinformatics. </ns3:p> <ns3:p> <ns3:bold>Methods</ns3:bold> : Colour s-LASCA imaging of virtual laser GB-speckles, a new method of high discrimination and typing of pathogenic viruses, has been developed. This method has been adapted to the detecting of natural mutations in nucleotide sequences, related to the spike glycoprotein (coding the gene «S») of SARS–CoV-2 gene as the molecular target. </ns3:p> <ns3:p> <ns3:bold>Results</ns3:bold> : The rate of the colouring images of virtual laser GB-speckles generated by s-LASCA can be described by the specific value of R. If the nucleotide sequences compared utilizing this approach the relevant images are completely identical, then the three components of the resulting colour image will be identical, and therefore the value of R will be equal to zero. However, if there are at least minimal differences in the matched nucleotide sequences, then the value of R will be positive. </ns3:p> <ns3:p> <ns3:bold>Conclusion</ns3:bold> : The high effectiveness of an application of the colour images of GB-speckles that were generated by s-LASCA- has been demonstrated for discrimination between different variants of the SARS–CoV-2 spike glycoprotein gene. </ns3:p>
The FEBS Journal in 2020: Open Access and quality versus quantity publishing (2020)

Seamus Martin holds the Smurfit Chair of Medical Genetics at the Smurfit Institute of Genetics, Trinity College Dublin, Ireland. His laboratory works on diverse aspects of cell death control, including the role of 'death receptors' as initiators of inflammation and the role of IL-1 family cytokines as key initiators of inflammation in the context of necrotic cell death. Seamus received the GlaxoSmithKline Award of The Biochemical Society (2006) and The RDS-Irish Times Boyle Medal (2015) for his work on the role of caspases in apoptosis and was elected to the Royal Irish Academy in 2006 and EMBO in 2009. He is the Editor-in-Chief of The FEBS Journal since 2014.
Programming in Objective-C (1983)

Programming in Objective-C is a concise, carefully written tutorial on the basics of Objective-C and object-oriented programming. The book makes no assumption about prior experience with object-oriented programming languages or with the C language (upon which Objective-C is based). And because of this, both novice and experienced programmers alike can use this book to quickly and effectively learn the fundamentals of Objective-C. Readers can also learn the concepts of object-oriented programming without having to first learn all of the intricacies of the underlying procedural language (C). This approach, combined with many small program examples and exercises at the end of each chapter, makes it ideally suited for either classroom use or self-study. Growth is expected in this language. At the January 2003 MacWorld, it was announced that there are 5 million Mac OS X users and each of their boxes ships with Objective-C built in.
Development of an Intramolecular Gassman’s [2+2] Cycloaddition (2011)

The development of an intramolecular variant of Gassman's cationic [2 + 2] cycloaddition is described herein.Mechanistic aspects of the stepwise nature of this cycloaddition process between vinyl acetals and unactivated olefins have been studied.We have also explored the scope of this reaction with regard to various oxygen-, nitrogen-, and carbon-tethered acetals to provide access to a diverse array of bicyclic scaffolds.Additionally, we have identified vinyl hemiaminals as having favorable reactivity for cationic [2 + 2] cycloaddition.
Evaluation of Three Wearable Computer Pointing Devices for Selection Tasks (2005)

This paper presents the results of an experiment comparing three commercially available pointing devices (a trackball, gyroscopic mouse and Twiddler2 mouse) performing selection tasks for use with wearable computers. The study involved 30 participants performing selection tasks with the pointing devices while wearing a wearable computer on their back and using a head-mounted display. The error rate and time to complete the selection of the circular targets was measured. When examining the results, the gyroscopic mouse showed the fastest mean time for selecting the targets, while the trackball performed with the lowest error rate.
Downregulation of Smac/DIABLO Expression in Renal Cell Carcinoma and Its Prognostic Significance (2004)

The present study demonstrates for the first time that Smac/DIABLO expression was downregulated in RCC and that no Smac/DIABLO expression in RCC predicted a worse prognosis. In addition, transfection with Smac/DIABLO sensitized RCC to TRAIL/cisplatin-induced apoptosis. These results suggest that Smac/DIABLO expression in RCC may be used as a prognostic parameter, and that enhancement of Smac/DIABLO expression in RCC may potentiate immunotherapy and chemotherapy.
More on Cross Products (1991)

(1991). More on Cross Products. The American Mathematical Monthly: Vol. 98, No. 9, pp. 850-851.
The role of GSM in the development of standards for a worldwide personal communications network (2003)

For the past five years, technical specifications have been written for a new digital cellular system in Europe. In many aspects, the new digital cellular system provide capabilities which are required in a personal communications network. Planners of future personal communications networks will be studying the rollout of this system in Europe to gain practical information on the usefulness and efficiency of services offered in this system. Also, the similarity in requirements for PCN and GSM systems sets the first stage for the GSM network to evolve into a worldwide personal communications network when such a network is developed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Constrained floorplan design for flexible blocks (2003)

The authors propose a simple and fast iterative improvement algorithm for solving the constrained floorplan design problem. The algorithm allows users to specify an aspect ratio for the bounding rectangle and constraints on the relative positions and separation requirements of blocks. In the first phase of the algorithm, two scaling factors for each flexible block are computed for adjusting the block dimensions iteratively. In the second phase, blocks are placed according to the constraint graphs. If no overlaps are detected, the algorithm stops; otherwise an edge is inserted into one of the constraint graphs to resolve the overlap between one pair of blocks. The algorithm then goes back to the first phase. Experimental results show that this algorithm tends to achieve the prespecified overall aspect ratio and produces floorplans with small overall area.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Common mistakes on face recognition based on video (2012)

Abstract: Automatic border control e gates relies on face recognition in video streams. Two family of methods could be imagined to define a common workflow: encode all that is possible or select the best image of the stream according to a quality assessment. In gates, giving an answer as soon as possible by encoding each and every possible image seems to lead to faster gates. Is it really the case? 1
P438Safety and efficacy of the Micra Transcatheter Pacemaker in different right ventricular positions (2017)

Background: Leadless pacemaker systems are an important upcoming device in clinical rhythmology. Currently two different products are available with the Micra system (0.8 cubic centimetres, 2.0 g capsule with 25.9 mm in length and an outer diameter of 6.7 mm) being the most used in the clinical setting to this date. The possibility to perform magnetic resonance imaging (MRI) is an important feature of modern pacemaker devices. Even though the Micra system is suitable for MRI, little is yet know on its impact on artifacts within the images. Purpose: The aim of our ex vivo study was to perform cardiac MRI to quantify the appearing artifacts in size and to evaluate if artifacts limit or inhibit the assessment of the surrounding myocardium. Methods: After ex vivo implantation of the leadless pacemaker (LP) in porcine model, hearts were filled with saline solution and fixed on wooden sticks upon a plastic container. The model was examined at 1.5 and at 3 Tesla using common conventional sequences and T2 mapping sequences as well. In addition, conventional X-rays and a CT scans were performed. Results: Correct implantation using the steerable device was feasible in all porcine hearts used in our ex vivo study. The figure shows MR images in "cine-like" sequences (SSFP-Sequence), here, the Micra pacemaker system produces a "shamrock-shaped" artifact that masks a small focal area without compromising the surrounding myocardium. The occurring artifact was larger at 3 Tesla (17.1% in long axis and 25.2% in short axis, expressed as % of total myocardial area) than compared to images obtained at 1.5 Tesla (14.8% in long axis and 17.8% in short axis). A similar result was found for the scar-sequence. The late enhancement (scar-) sequences were slightly more prone to artifacts at 3.0 Tesla, leaving the right ventricle and the septum affected by a bright, hyperintense perifocal rim (12.4% and 12.1% at 1.5 Tesla vs. 11.9% and 14.9% at 3.0 Tesla). However, a large proportion of the left ventricular myocardium still remained accessible for image analysis. Similar findings were generated at 1.5 T. Only the perifocal hyperintense rim artifacts in the Turbospin-echo (TSE) sequences with selective fat suppression (SPIR) were visually slightly smaller (10.2% vs. 19.9%). No relevant differences were found in perfusion and T2 map sequences. Conclusions: The use of the Micra system in cardiac MRI appeared to be feasible. We think that performing the most common sequences in Micra patients is possible, even though the right ventricle and the surrounding septal region might be overshadowed by occurring artefacts. In our opinion, the most important clinical MRI evaluations (the detection of major ischemic areas or inflammatory processes) will still be possible in Micra patients. We suggest the use of 1.5 Tesla will be the preferred method in clinical practice.