gebhart/patrepeval huggingface dataset:
Real-time quantification of the multidrug resistance-1 gene expression in relapsed acute promyelocytic leukemia treated with arsenic trioxide. (2002)

The multidrug resistance-1 (MDR-1) gene expression in 16 patients with relapsed acute promyelocytic leukemia (APL) treated with arsenic trioxide (AS 2 O 3 ) and consolidated with idarubicin was quantified by quantitative polymerase chain reaction. MDR-1 expression was increased in nine patients (56%) at relapse (10-3,000 times the presentation level), and further increased in about half who relapsed post-AS 2 O 3 treat-ment. MDR-1 expression had no effect on the response to AS 2 O 3 , and did not increase relapses after AS 2 O 3 and chemotherapy. We conclude that the increased MDR-1 expression in relapsed APL might be overcome by AS 2 O 3 . Factors other than MDR-1 expression might be involved in relapses post-AS 2 O 3 treatment.
Traffic and mobility data collection for real-time applications (2010)

Successful development of effective real-time traffic management and information systems requires high quality traffic information in real-time. This paper presents the state-of-the-art of traffic and general mobility sensory technology and a suite of methods for data pre-processing and cleaning for real-time applications. We propose a suite of methods and techniques to be applied from traffic data acquisition, preprocessing, transformation and integration until data advanced processing and transfer. Next, we detail some techniques for data preprocessing and integration, or fusion, phases. Even though the comprehensive use of historical traffic data and assignment models to support the most part of online services and operations, real-time data is extremely important to promote models' accuracy and, therefore, the reliability of information and outputs derived from data fusion and processing. Together with techniques and theoretical formulas we present a case study applied to the Portuguese Brisa's A5 motorway, a 25 km inter-urban highway between Lisbon and Cascais. Traffic on this motorway heading to Lisbon in the morning rush hours typically experiences high levels of congestion. Brisa, the motorway operator company, has equipped A5 with a variety of traffic sensors to be used in a real-time multi-purpose way, either for traffic management and control or for traveler information and third-part applications.
Effect of ring size on the photochemical behavior of .beta.,.gamma.-unsaturated ketones (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of ring size on the photochemical behavior of .beta.,.gamma.-unsaturated ketonesPaul S. Engel and Mary A. SchexnayderCite this: J. Am. Chem. Soc. 1972, 94, 26, 9252–9254Publication Date (Print):December 1, 1972Publication History Published online1 May 2002Published inissue 1 December 1972https://pubs.acs.org/doi/10.1021/ja00781a059https://doi.org/10.1021/ja00781a059research-articleACS PublicationsRequest reuse permissionsArticle Views62Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cooperative Amplification-Based Electrochemical Sensor for the Zeptomole Detection of Nucleic Acids (2013)

In this work, we developed a multiple-amplification-based electrochemical sensor for ultrasensitive detection of nucleic acids using a disease-related sequence of the p53 gene as the model target. A capture probe (CP) with a hairpin structure is immobilized on the electrode surface via thiol-gold bonding, while its stem is designed to contain a restriction site for EcoRI. In the absence of target DNA, the probe keeps a closed conformation and forms a cleavable region. After treatment with EcoRI, the target binding portion (loop) plus the biotin tag can be peeled off, suppressing the background current. In contrast, the CP is opened by the target hybridization, deforming the restriction site and forcing the biotin tag away from the electrode. On the basis of the biotin-streptavidin complexation, gold nanoparticles (GNPs) modified with a large number of ferrocene-signaling probes (Fc-SPs) are captured by the resulting interface, producing an amplified electrochemical signal due to the GNP-based enrichment of redox-active moieties. Furthermore, Fc tags can be dragged in close proximity to the electrode surface via hybridization between the signaling probes and the CP residues after EcoRI treatment, facilitating interfacial electron transfer and further enhancing the signal. With combination of these factors, the present system is demonstrated to achieve an ultrahigh sensitivity of zeptomole level and a wide dynamic response range of over 7 orders of magnitude.
Adaptive Wisp Tree: a multiresolution control structure for simulating dynamic clustering in hair motion (2003)

Realistic animation of long human hair is difficult due to the number of hair strands and to the complexity of their interactions. Existing methods remain limited to smooth, uniform, and relatively simple hair motion. We present a powerful adaptive approach to modeling dynamic clustering behavior that characterizes complex long-hair motion. The Adaptive Wisp Tree (AWT) is a novel control structure that approximates the large-scale coherent motion of hair clusters as well as small-scaled variation of individual hair strands. The AWT also aids computation efficiency by identifying regions where visible hair motions are likely to occur. The AWT is coupled with a multiresolution geometry used to define the initial hair model. This combined system produces stable animations that exhibit the natural effects of clustering and mutual hair interaction. Our results show that the method is applicable to a wide variety of hair styles.
GPRS-PACS: evolution of T-PACS towards third generation wireless services (2002)

The Personal Access Communications System (PACS) is an air interface standardized by the American National Standards Institute (ANSI). It is a low tier wireless communications system designed to support high quality voice, voiceband data, digital data, and messaging services. This paper describes third generation advancements to PACS. Our proposed protocol, GPRS-PACS, adopts principles of GPRS over the PACS physical layer to handle packet traffic. The issues covered include protocol layering, the channel and superframe structures, the RLC/MAC block formats, and the MAC layer procedures.
Synthetic Approaches to Polypyridyl Bridging Ligands with Proximal Multidentate Binding Sites (2005)

[reactions: see text] A series of 12 bridging ligands was prepared. These ligands include a central linker appended to two 1,8-naphthyrid-2-yl or two 1,10-phenanthrolin-2-yl units. The linkers include pyridazin-3,6-diyl, 1,8-naphthyrid-2,7-diyl, 2,2'-bipyrid-6,6'-diyl, 1,10-phenanthrolin-2,9-diyl, 1,2-di(2'-pyrid-6'-yl)ethyne, and 3,6-di(2'-pyrid-6'-yl)pyridazine. The ligands were synthesized from the diacetyl derivative of the central linker by a Friedländer condensation with either 2-aminonicotinaldehyde or 8-amino-7-quinolinecarbaldehyde. The precursor diacetyl derivatives were, in turn, prepared by pathways involving Stille and Sonogashira couplings. Examination of the electronic absorption spectra of the bridging ligands shows the strongest correlation to be between pairs of ligands having the same central linker. Complexation studies will follow.
YBa2Cu3O7-δ Angle Grain Boundary Junction on Si Bicrystal Substrate (1991)

Si bicrystal substrates with angle grain boundaries (AGB) have been fabricated for the first time by a diffusion bonding technique using the hot-press method. YBa 2 Cu 3 O 7-δ (YBCO) epitaxial thin films are grown on the Si bicrystal substrates with yttria (Y 2 O 3 ) and yttria-stabilized zirconia (YSZ) buffer layers by rf magnetron sputtering. The properties of bridge-type junctions patterned by excimer laser have been studied from 4.2 K to 77 K and by microwave irradiation. It is found that the critical current density of the AGB junction ( J c A ) is always less than that of either bridge made on single-crystal grains ( J c G ). The effects of the temperature and microwave radiation show that the properties of the bridges on the grains are limited by flux creep. In contrast, the properties of the AGB junction with the angle larger than 10° show the Josephson effect.
High-Throughput and Low-Power Architectures for Reed Solomon Decoder (2006)

This paper presents a uniform comparison between various algorithms and architectures used for Reed Solomon (RS) decoder. For each design option, a detailed hardware analysis is provided, in terms of gate count, latency and critical path delay. A new low-power syndrome computation is proposed in the paper. Dual-line architecture of modified Berlekamp Massey algorithm was chosen for Ultra Wide-band (UWB) as an application example. The results obtained are very encouraging both in terms of silicon area and power. A detailed analysis of results is presented and they are also compared with other published industrial and academic designs. I. INTRODUCTION Reed Solomon (RS) codes have been widely used in a variety of communication systems. Continual demand for ever higher data rates and storage capacity makes it necessary to devise very high-speed implementations of RS decoders. A number of algorithms are available and this often makes it difficult to determine the best choice due to the number of variables and trade-offs available. For IEEE 802.15-03 standard proposal (commonly known as UWB) in particular, very high data rates for transmission are needed. Since the standard is also meant for portable devices, power consumption is of prime concern. There is no clear algorithm or architecture that can meet the low-power and high-throughput requirements of UWB. In this paper, a uniform comparison of various designs and architecture is presented. Dual-line architecture of BerleKamp Massey algorithm was implemented, with a lot of other optimisations to the conventional design. In the next section we present an introduction to RS codes and the decoder structure, followed by syndrome computation architecture. The design space is explored in the following section. We then present the results obtained for the archi- tecture chosen for UWB followed by some optimisations to the design. The results are then compared with existing architectures in the section on benchmarking followed by conclusions.
Picosecond imaging circuit analysis (2000)

A newly developed optical method for noninvasively measuring the switching activity of operating CMOS integrated circuit chips is described. The method, denoted as picosecond imaging circuit analysis (PICA) can be used to characterize the gate-level performance of such chips and identify the locations and nature of their operational faults. The principles underlying PICA and examples of its use are discussed.
Role of community health worker in a mobile health program for early detection of oral cancer (2019)

The trained CHWs can aid in identifying oral potentially malignant disorders and they can be utilized in oral cancer-screening program mHealth effectively.
Quadrupolar Axialization (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Interfacial Inhibitors (2018)

Interfacial inhibition is a widespread molecular mechanism by which natural products, such as toxins, inactivate macromolecular complexes by trapping normally transient conformational intermediates. This mechanism is effectively harnessed for therapeutic purposes, primarily in the case of antibacterial and chemotherapeutic anticancer drugs. This chapter provides case studies for drugs targeting protein–DNA interfaces, such as topoisomerase inhibitors and HIV integrase inhibitors. Examples of interfacial inhibitors for protein–protein interfaces are also provided for gyrase, STING and Arp2–3 inhibitors. Interfacial inhibition offers prospects for targeting previously ‘undruggable’ targets, including transcription, replication and chromatin-remodelling complexes. From a discovery viewpoint, the interfacial inhibition principle establishes the value of natural-product screening, the importance of non-competitive inhibitors and the value of high-throughput assays based on enhancement of macromolecular complex formation rather than disruption.
A parametric modeling approach to Hilbert transformation (1998)

A parametric approach to compute the Hilbert transform (HT) of a real signal is proposed. A scaled version of the real signal is raised to the exponent of Napier's base, and an all-pole signal model is fitted to approximate the resulting signal as though it were the envelope. An error criterion that flattens this envelope is then minimized over a set of complex Fourier coefficients. The resulting approximation is guaranteed to be a minimum-phase (MinP) signal. Since a MinP signal has the property that the logarithm of its envelope and its phase are related by the HT, it follows that the resulting phase of MinP approximation yields the desired HT.
Adaptive image processing by means of polynomial transforms (1992)

Previous work at the Institute for Perception Research has resulted in a new model for representing images, called a polynomial transform. This transform is perceptually relevant since it mimics properties of the early stages of human vision such as localization and decomposition of luminance changes into specific basic patterns, i.e., localized polynomials. The transform also has interesting signal processing properties, some of which will be illustrated in this paper. Image interpolation is an example of how polynomial transforms can be used for image restoration. It is derived that the polynomial transform coefficients of a blurred and sampled image are related by a linear transformation to the polynomial transform coefficients of the original image. By inverting this transformation, we can obtain deblurring and interpolation. This inversion is based on the assumption that the image can be locally approximated by a low-order polynomial description. By adopting a fixed degree for this a priori polynomial description, we obtain non-adaptive interpolation algorithms. The performance of the algorithm can be further improved by varying the degree of this a priori polynomial description depending on whether the image region is locally uniform or non- uniform. Especially in the presence of noise, this adaptivity is usually very important. It is shown how such space-variant image processing can be easily described and implemented using polynomial transforms. Subjective evaluation of the image interpolation technique aims at optimizing the parameter values of the algorithm, as well as comparing the new algorithm to existing interpolation techniques. Some results of this evaluation are presented.
The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates. (1993)

This study examined the effect of 2 yr of treatment with the aminobisphosphonate alendronate (ALN) (0.05 or 0.25 mg/kg i.v. ALN every 2 wk) on estrogen deficiency bone loss and bone strength changes in ovariectomized (OVX) baboons (n = 7 per group) and the ALN mode of action at the tissue level. Biochemical markers of bone turnover increased in OVX animals and were maintained by ALN treatment at non-OVX levels (low dose) or below (high dose). 2 yr of treatment produced no cumulative effects on bone turnover markers. Histomorphometry showed a marked increase in cancellous bone remodeling in OVX animals. Activation frequency increased from 0.48 to 0.86 per yr (L5 vertebra), and the osteoid surfaces from 9 to 13.5% (P < 0.05). No changes were observed in eroded and osteoclast surfaces. ALN treatment decreased activation frequency and indices of bone formation to control levels (low dose) or below (high dose), did not change indices of mineralization, and increased bone mineral density (BMD) in the lumbar vertebrae (L2-L4) by 15% at 0.25 mg/kg (P < 0.05), relative to vehicle-treated animals. The mean strength of cancellous bone (L4) increased by 44% (low ALN dose) and 100% (high dose), compared with vehicle. The strength of individual bones correlated with the square of the L2-L4 BMD (r = 0.91, P < 0.0034). In conclusion, ALN treatment reversed the effects of ovariectomy on cancellous bone turnover and increased bone mass and bone strength in baboons.
ChemInform Abstract: THE REACTIONS OF SOME 1,1‐DIALKYLHYDRAZINES WITH UNSATURATED AND BROMO ALIPHATIC ACIDS (1980)

Abstract Die Dialkylhydrazine (I) werden mit verschiedenen ungesättigten bzw. gesättigten Säuren bzw. Estern (II), (V), (VI), (VIII) bzw. (XII) unter Bildung der jeweils angegebenen Produkte umgesetzt.
Natural Killer Cells: The Linchpin for Successful Cancer Immunotherapy (2021)

Cancer immunotherapy is a highly successful and rapidly evolving treatment modality that works by augmenting the body's own immune system. While various immune stimulation strategies such as PD-1/PD-L1 or CTLA-4 checkpoint blockade result in robust responses, even in patients with advanced cancers, the overall response rate is low. While immune checkpoint inhibitors are known to enhance cytotoxic T cells' antitumor response, current evidence suggests that immune responses independent of cytotoxic T cells, such as Natural Killer (NK) cells, play crucial role in the efficacy of immunotherapeutic interventions. NK cells hold a distinct role in potentiating the innate immune response and activating the adaptive immune system. This review highlights the importance of the early actions of the NK cell response and the pivotal role NK cells hold in priming the immune system and setting the stage for successful response to cancer immunotherapy. Yet, in many patients the NK cell compartment is compromised thus lowering the chances of successful outcomes of many immunotherapies. An overview of mechanisms that can drive NK cell dysfunction and hinder immunotherapy success is provided. Rather than relying on the likely dysfunctional endogenous NK cells to work with immunotherapies, adoptive allogeneic NK cell therapies provide a viable solution to increase response to immunotherapies. This review highlights the advances made in development of NK cell therapeutics for clinical application with evidence supporting their combinatorial application with other immune-oncology approaches to improve outcomes of immunotherapies.
<title>Low-loss Y-couplers for fiber optic gyro applications</title> (1991)

The development of low loss, pigtailed Y-couplers in Lithium Niobate is described for operation at 830 nm wavelength. These couplers are fabricated using low loss S-bend transitions. Correlation is shown between S-bend parameters and Y-coupler losses.
New Technique for Early Screening of Developmental Dysplasia of the Hip: Pilot Study (2003)

An acoustical technique has been developed for early screening of developmental dysplasia of the hip (DDH) in neonates by comparing the sound transmitted across the hips while a vibratory force was applied to the sacrum. The baseline for 90 normal neonates has been established and tests in the frequency bands of 200, 250, and 315 Hz were found to be most effective, achieving high coherence and smallest discrepancy. Sixteen patients with unilateral DDH were examined and the results suggested that coherence below 0.8 in at least one of these frequency bands was strongly indicative of structural asymmetry between both hips, and there was a significant difference between normal neonates and patients with unilateral DDH. By setting the cut-off discrepancy at 2.0 dB, the best sensitivity (100%) would be achieved, and this could be proposed as the threshold for wide-scale screening of DDH.
Perceptual Displays Today &amp; Tomorrow &#x2013; Evangelism, Productization, and Evaluation (2022)

Evolution of displays in various industries such as consumer electronics, aerospace, automotive, gaming and digital signage has been a key factor to engage and satisfy consumers. In this talk, I focus on Automotive market as one of the fastest growing display markets, but most discussed matters are applicable to other display verticals. Perceptual and Immersive display user experience are attracting more manufacturers these days to build products matching the end user&#x2019;s expectation and needs while interacting with displays such as: perfect visibility in all conditions, personalization, less eye fatigue, seamless interaction - in one word &#x201C;mimic real world&#x201D; experience. Hardware and software advancements are critical but not enough to fulfil today&#x2019;s knowledgeable consumer demands. The User Experience has become one of the highest priorities leading companies to develop dedicated user experience or UX teams to study the need of the end user. Multi-disciplinary teams of experts are built to tackle the UX optimization challenge._x005F_x000D_ _x005F_x000D_ In this talk I will share our experience evangelizing the benefits of Perceptual displays, challenges of such evangelism, productization of it and most importantly measuring the performance of perceptual displays in a comparable way to traditional displays.
Increase of neuronal sprouting and migration using 780 nm laser phototherapy as procedure for cell therapy (2009)

780 nm laser phototherapy of embryonic rat brain cultures embedded in hyaluronic acid-laminin gel and attached to positively charged cylindrical MCs, stimulated migration and fiber sprouting of neuronal cells aggregates, developed large size neurons with dense branched interconnected network of neuronal fibers and, therefore, can be considered as potential procedure for cell therapy of neuronal injury or disease.