gebhart/patrepeval huggingface dataset:
Evidence that mCPP may have behavioural effects mediated by central 5‐HT1C receptors (1988)

1. The effects of 1-(3-chlorophenyl)piperazine (mCPP) and 1-[3-(trifluoromethyl)phenyl] piperazine (TFMPP) on activity of rats in a novel cage, and on the rotorod and elevated bar co-ordination tests was examined. 2. Peripherally administered mCPP and TFMPP dose-dependently reduced locomotion, rearing, and feeding scores but not grooming of freely fed rats placed in a novel observation cage. Yawning behaviour was increased. Similar effects were also observed after injection of mCPP into the 3rd ventricle. 3. Co-ordination on a rotating drum of both untrained and trained rats was impaired following mCPP but co-ordination on an elevated bar was not. 4. The hypoactivity induced by mCPP was opposed by three antagonists with high affinity for the 5-hydroxytryptamine (5-HT1C) site; metergoline, mianserin, cyproheptadine and possibly also by a fourth antagonist mesulergine. Metergoline, mianserin and cyproheptadine also opposed the reduction in feeding scores. However, neither effect of mCPP was antagonized by the 5-HT2-receptor antagonists ketanserin or ritanserin, the 5-HT3-receptor antagonist ICS 205-930, the 5-HT1A and 5-HT1B-receptor antagonists (-)-pindolol, (-)-propranolol and (+/-)-cyanopindolol or the 5-HT1A-, 5-HT2- and dopamine receptor antagonist spiperone. The specific alpha 2-adrenoceptor antagonist idazoxan was also without effect. 5. Hypoactivity induced by TFMPP was similarly antagonized by mianserin but unaffected by (+/-)-cyanopindolol. 6. These results suggest that the hypoactivity is mediated by central 5-HT1C-receptors and that mCPP and possibly TFMPP may be 5-HT1C-receptor agonists. 7. As mianserin, cyproheptadine and mesulergine in the absence of mCPP did not increase locomotion but increased the number of feeding scores, the activation of 5-HT1C-receptors may be of physiological importance in the control of appetite. The possible relevance of these results to the therapeutic and side-effects of clinically used antidepressants (particularly trazodone and mianserin) and anorexigenic drugs is discussed.
Aldazines in the Castagnoli–Cushman Reaction (2018)

Aldazines were employed in the Castagnoli–Cushman reaction of homophthalic anhydride for the first time. The reaction proved to be distinctly diastereoselective when conducted at room temperature in acetonitrile, yielding predominantly the kinetic cis-configured adduct as a racemate. Thermodynamically more stable trans-configuration could be attained either via heating the cis-configured product in DMSO or via the action of a base (imidazole) in the course of CDI-promoted esterification or amidation of the carboxylic acid function in the initial adducts. Further manipulation of the remaining N-acylhydrazone moiety in the latter led to N-alkyl- or fully unprotected N-aminolactams.
CSI-Based Wireless Localization and Activity Recognition Using Support Vector Machine (2019)

With the development of the information technology, human activity recognition and localization has received much attentions, since they can be utilized in many fields. In this paper, a new activity recognition and localization algorithm using channel state information (CSI) measurement is proposed. The problem of activity recognition and localization are formulated as the problem of machine learning which are solve with the support vector machine (SVM) approach. In the off-line phase, after the data normalization and principal component analysis (PCA) preprocessing of the CSI measurements, the (CSI measurement, label of activity) training data set and the (CSI measurement, position information) training data set for each activity can be formed. The SVM technique are utilized for activity based classification learning and position based regression learning. At last, the activity classification function and position regression function are obtained. In the on-line phase, after the data preprocessing of the received CSI measurements, the activity is estimated by the activity classification function at first. Then, the position regression function correspond to the estimated activity result is chosen for position estimation. Experimental results illustrated the activity recognition and localization performance of the proposed algorithm.
Clock trees: differential or single ended? (2005)

A low-swing differential clock distribution scheme is presented, and is compared with widely used single ended clock distribution. Test chips based on these two clocking styles are designed with 1 GHz clocks in a 90 nm technology. Low-swing differential clock trees are seen to have 25-42% less sensitivity to power supply noise and 6% less sensitivity to manufacturing variations than single ended clock trees, which leads to significant savings in skew and jitter. Another important contribution is the development of techniques to design robust single ended and differential clock trees.
Modeling repetitive, non‐globular proteins (2016)

While ab initio modeling of protein structures is not routine, certain types of proteins are more straightforward to model than others. Proteins with short repetitive sequences typically exhibit repetitive structures. These repetitive sequences can be more amenable to modeling if some information is known about the predominant secondary structure or other key features of the protein sequence. We have successfully built models of a number of repetitive structures with novel folds using knowledge of the consensus sequence within the sequence repeat and an understanding of the likely secondary structures that these may adopt. Our methods for achieving this success are reviewed here.
Decreased Circulating Myeloid Derived Suppressor Cells at First Follow-up Predict Favorable Response to Immunotherapy in a Randomized Trial of Nivolumab and Bevacizumab in Recurrent GBM (2019)

INTRODUCTION: A potential barrier to successful immunotherapy response in glioblastoma (GBM) is myeloid-derived suppressor cells (MDSCs): an immature immunosuppressive cell elevated in the circulation and tumor of GBM patients. Given a limited set of biomarkers predictive of response to immunotherapy in GBM, we explored the change in MDSC levels with immunotherapy to predict treatment response. METHODS: A retrospective analysis was performed on patients in a randomized, phase 2 study of nivolumab and bevacizumab at GBM first recurrence. Clinical and radiographic data were analyzed for disease progression or treatment response via Response Assessment in Neuro-Oncology (RANO) criteria. Blood was collected prior to treatment and at first imaging follow-up. Peripheral blood mononuclear cells (PBMCs) were isolated from whole blood samples and analyzed. Characterization of circulating immune cells was performed using flow cytometry. RESULTS: A total of 9 patients were identified as responders or nonresponders at a median time of 8.7 wk (range 6.9-10.0) after therapy initiation. MDSCs, as a percentage of total PBMCs, were elevated at baseline in responders compared to nonresponders (4.9% ± 0.7 vs 2.6% ± 0.2, P = .019), which reversed at follow up (1.8% ± 0.4 vs 5.8% ± 1.1, P = .032). There was a 6.4 fold decrease in MDSCs as a percentage of total PBMCs between baseline and first imaging follow-up in responders as compared to nonresponders (P = .001). When looking at subtypes of MDSCs, a 4.9 fold decrease in granulocytic MDSCs (G-MDSCs) was noted in responders over nonresponders (P = .010). Further investigation of this cohort by simultaneous single-cell analysis of transcriptome and surface epitopes is ongoing. CONCLUSION: Differences in circulating MDSC levels that were specific to responders and nonresponders were seen both before and after therapy initialization, with decreases in MDSCs (specifically G-MDSCs) being correlated with treatment response. Characterization of MDSCs in the peripheral blood may be helpful in identifying GBM patients likely to benefit from immunotherapy.
Immunochemical evidence for a role of complex carbohydrate chains in thyroglobulin antigenicity. (1986)

Thyroglobulin secreted by porcine thyroid cells in serum-free culture was previously found (Ronin, C., Fenouillet, E., Hovsepian, S., Fayet, G., and Fournet, B. (1986) J. Biol. Chem. 261, 7287-7293) to contain more highly branched complex carbohydrate chains than the thyroid-derived molecules. When assayed for their ability to react with polyclonal antibodies directed against the natural prohormone in competitive radioimmunoassays, using the porcine antigen as iodinated tracer and standard competitor, in vitro thyroglobulin appeared to be 4-fold less immunoreactive than the in vivo molecule. However, both types of thyroglobulin exhibited superimposable incomplete displacement curves after peripheral deglycosylation using a mixture of neuraminidase, alpha-, and beta-galactosidases while they behave as good competitors as the native antigen after removal of the majority of the carbohydrate chains by Endo-beta-N-acetylglucosaminidase F. Solid-phase binding assays revealed that in vitro thyroglobulin was able to bind less antibodies than its thyroid-derived counterpart before as well as after treatment with exo- or endoglycosidases. Furthermore, only 20% of thyroglobulin biosynthetically labeled with glucosamine could be precipitated with specific antibodies followed by addition of staphylococcal-protein A, whereas up to 61% of the labeling was specifically bound when the antibodies were preincubated with protein A. After pronase digestion, both thyroglobulin-like material displayed different carbohydrate structures as judged by concanavalin A-Sepharose analysis. Thus, substituting multiantennary complex carbohydrate chains to the usual biantennary and high mannose structures present on thyroid-derived thyroglobulin had a profound effect on the prohormone immunoreactivity.
A Review of Optical Coherence Elastography: Fundamentals, Techniques and Prospects (2013)

In optical coherence elastography, images are formed by mapping a mechanical property of tissue. Such images, known as elastograms, are formed on the microscale, intermediate between that of cells and whole organs. Optical coherence elastography holds great promise for detecting and monitoring the altered mechanical properties that accompany many clinical conditions and pathologies, particularly in cancer, cardiovascular disease and eye disease. In this review, we first consider how the mechanical properties of tissue are linked with tissue function and pathology. We then describe currently prominent optical coherence elastography techniques, with emphasis on the methods of mechanical loading and displacement estimation. We highlight the sensitivity to microstrain deformations at tens of micrometer resolution. Throughout, optical coherence elastography is considered in the context of other elastography methods, mainly ultrasound elastography and magnetic resonance elastography. This context serves to highlight its advantages, early stage of development of applications, and strong prospects for future impact.
Involvement of Cyclin D and p27 in Cell Proliferation Mediated by ROCK Inhibitors Y-27632 and Y-39983 During Corneal Endothelium Wound Healing (2013)

These findings show that ROCK inhibitors employ both cyclin D and p27 via PI 3-kinase signaling to promote CEC proliferation, and that Y-39983 may be a more potent agent than Y-27632 for facilitating corneal endothelium wound healing.
ChemInform Abstract: Intramolecular Diels—Alder Synthesis of 7‐Aza‐α‐carboline Compounds. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Simulation and evaluation of nicotine intake during passive smoking: Cotinine measurements in body fluids of nonsmokers given intravenous infusions of nicotine (1990)

The technique of monitoring cotinine concentrations in body fluids as a means of measuring nicotine intake during passive smoking has been evaluated in two studies, both of which used intravenous infusion to stimulate nicotine intake. In the first study, nicotine and cotinine were given separately, for 1 hour in four different intravenous doses (3.2, 15.4, 30.9, and 61.7 nmol/min) to each nonsmoker. In the second study, nicotine and cotinine were infused for 4 hours; each subject received five different doses of nicotine (1.5, 3.1, 6.2, 10.8, and 15.4 nmol/min) and one of cotinine (10.8 nmol/min). The concentration of cotinine was constant in both plasma and saliva from 1 to 4 hours after the nicotine infusion; the plateau levels of cotinine were found to be linearly and directly related to the nicotine intake. The ratio of salivary to plasma cotinine was 1:1.27. A linear relationship was also found between nicotine and cotinine infusion rates and the AUC values for cotinine. The fraction metabolized to cotinine was found to be about 0.5. The results from these studies show that: (1) there is a linear relationship between the plateau concentration of cotinine and the amount of nicotine infused over a period of 1 up to 4 hours; (2) salivary cotinine provides the same information on nicotine intake as does plasma cotinine; and (3) single measurements of either plasma or salivary cotinine concentrations at 1 to 4 hours after the exposure could be used to predict the nicotine intake during 1 to 4 hours of environmental tobacco smoke exposure.
Effect of nano-grain on the memory characteristics of high-κ HfAlO charge trapping layers for nano-scale non-volatile memory device applications (2007)

2007 International Conference on Solid State Devices and Materials,Effect of nano-grain on the memory characteristics of high-κ HfAlO charge trapping layers for nano-scale non-volatile memory device applications
Transparent ATO/epoxy nanocomposite coating with excellent thermal insulation property (2012)

Transparent antimony-doped tin oxide (ATO)/epoxy nanocomposites, as glass thermal insulation coating, were prepared by incorporating ATO nanoparticles into a transparent epoxy matrix. The effect of ATO content on the optical and thermal insulation property of ATO/epoxy coating was studied. The results show that the ATO/epoxy coating with 1 wt% ATO has excellent optical properties, that is, visible light transmittance above 50% and shading coefficient of 0.54 are simultaneously achieved. In addition, the large temperature difference between the chambers coated respectively with the ATO/epoxy glass sheet and the common glass sheet indicates that the prepared ATO/epoxy nanocomposite coating has excellent thermal insulation property.
A Prospective, Comparative Study of the Immune Response to Inactivated Influenza Vaccine in Pediatric Liver Transplant Recipients and Their Healthy Siblings (2008)

The diminished cell-mediated immune response to influenza vaccination that was observed in pediatric liver transplant recipients suggests that the current vaccine strategy may not provide optimal protection. Because of concerns regarding potential emergence of more virulent influenza strains, further studies are warranted to determine if IFN-gamma responses are predictive of efficacy and to identify the optimal vaccination strategy to protect populations with a high risk of infection.
Antiviral Effect of Ginsenosides rk1 against Influenza a Virus Infection by Targeting the Hemagglutinin 1-Mediated Virus Attachment (2023)

Influenza A virus (IAV) infections have been a serious hazard to public health everywhere. With the growing concern of drug-resistant IAV strains, there is an urgent need for novel anti-IAV medications, especially those with alternative mechanisms of action. Hemagglutinin (HA), an IAV glycoprotein, plays critical roles in the early stage of virus infection, including receptor binding and membrane fusion, making it a good target for developing anti-IAV drugs. Panax ginseng is a widely used herb in traditional medicine with extensive biological effects in various disease models, and its extract was reported to show protection in IAV-infected mice. However, the main effective anti-IAV constituents in panax ginseng remain unclear. Here, we report that ginsenoside rk1 (G-rk1) and G-rg5, out of the 23 screened ginsenosides, exhibit significant antiviral effects against 3 different IAV subtypes (H1N1, H5N1, and H3N2) in vitro. Mechanistically, G-rk1 blocked IAV binding to sialic acid in a hemagglutination inhibition (HAI) assay and an indirect ELISA assay; more importantly, we showed that G-rk1 interacted with HA1 in a dose-dependent manner in a surface plasmon resonance (SPR) analysis. Furthermore, G-rk1 treatment by intranasal inoculation effectively reduced the weight loss and mortality of mice challenged with a lethal dose of influenza virus A/Puerto Rico/8/34 (PR8). In conclusion, our findings reveal for the first time that G-rk1 possesses potent anti-IAV effects in vitro and in vivo. We have also identified and characterized with a direct binding assay a novel ginseng-derived IAV HA1 inhibitor for the first time, which could present potential approaches to prevent and treat IAV infections.
8. The Versatile Role of Fat Injection during Various Genioplasties (2023)

PURPOSE: Fat injection is increasingly common in aesthetic surgery due to autogenous volume augmentation, anti-inflammatory properties of adipocyte stem cells, regenerative potential, and restoration of youthful aesthetics. However, there is sparsity in the literature to the chin and corresponding complications. We report our experience with fat injection during chin surgery. METHODS: Data from our institution was collected from 2016-2022 for patients who underwent chin fat grafts and genioplasty alone. Patients with chin fat injection were divided into isolated chin fat injection (CFI), combined facial and chin fat injection (FFCFI) and those who underwent genioplasty or osteotomy in combination with chin fat injection (CFIO). Patient demographics and surgical details were compiled for each patient. Complications and reoperations were compared using Fischer’s exact test compared to genioplasty alone. RESULTS: A total of 181 patients were included in the final analysis, with 14 CFI patients, 130 FFCFI patients, 24 CFIO patients, and 13 patients who underwent genioplasty alone. Additional fat injections were required in 17 (9.4%) patients overall, which included 14 FFCFI patients (10.8%) and three CFIO patients (12.5%) (p=0.73). No patients who underwent genioplasty alone or CFI required reoperation. There were no significant differences in complications between the genioplasty-alone (0%) in comparison to the CFI (7.1%; p=1.00), FFCFI (8.3%; p=0.53), or CFIO cohorts (7.7%; p=1.00). CONCLUSION: Fat injection provides options for augmentation on patients as either an isolated procedure or in combination with osteotomies for enhanced aesthetic outcomes, and has low complication rates.
Thermal stability of polypyrroles (1992)

Abstract The effect of dopants and level of doping on the thermal stability of polypyrrole at 90, 120 and 150°C in dry air and nitrogen was investigated by monitoring the decay of conductivity. Polymers doped with aromatic anions ( p ‐toluene sulphonate and p ‐chlorobenzene sulphonate) exhibit better stability than polymers doped with an aliphatic anion (dodecyl sulphate). The conductivity decay appears to follow diffusion controlled kinetics. After an initial decrease in conductivity, polypyrrole doped with p ‐toluene sulphonate anion maintains a constant conductivity at 150°C in air for at least 4 weeks. Dedoping results in materials of lower conductivity but greater thermal stability. Differential scanning calorimetry (DSC) and thermogravimetry (TG) were found to be useful techniques to characterize and investigate thermal stability. Oxidation of polypyrrole films, monitored by DSC, shows diffusion controlled kinetics. Although both oxidation and conductivity decay show typical diffusion kinetics, oxidation is a necessary but not sufficient condition for the decay.
'I've Never Thought of That Before': Organisational Role Analysis and Systems Development (2005)

This paper draws from a brief consultancy project with a work group in a large secondary college. It illustrates the unconscious and systemic dimensions of work role experience by showing how the personal work history of one group member attracted and reflected the changing relatedness between teachers and library staff within the school system as a whole. The use of organisational role analysis with an existing work group enabled interpersonal tensions to be understood and managed as part the evolution of the school within its changing context.
Tværsektorielt samarbejde ved behandling af patienter med type 2-diabetes (2018)

To optimize medical care, Danish guidelines for type 2 diabetes emphasize cross-sectoral collaboration. Risk stratification is recommended as a model of organizing care in terms of distributing tasks and responsibilities between primary and secondary healthcare sectors. Collaboration between the sectors is expected to be beneficial for patients and ensure rational utilization of resources. Challenges such as inter-sectoral communication, sharing of data and unambiguous responsibility underline the need for continuous optimization of the organization of cross-sectorial diabetes management.
The Effect of Helical CT on X-Ray Attenuation (1997)

The measurement of X-ray attenuation does not vary significantly with the use of the helical technique.
Desirable cytolytic immune effector cell recruitment by interleukin-15 dendritic cells (2017)

Success of dendritic cell (DC) therapy in treating malignancies is depending on the DC capacity to attract immune effector cells, considering their reciprocal crosstalk is partially regulated by cell-contact-dependent mechanisms. Although critical for therapeutic efficacy, immune cell recruitment is a largely overlooked aspect regarding optimization of DC vaccination. In this paper we have made a head-to-head comparison of interleukin (IL)-15-cultured DCs and conventional IL-4-cultured DCs with regard to their proficiency in the recruitment of (innate) immune effector cells. Here, we demonstrate that IL-4 DCs are suboptimal in attracting effector lymphocytes, while IL15 DCs provide a favorable chemokine milieu for recruiting CD8+ T cells, natural killer (NK) cells and gamma delta (γδ) T cells. Gene expression analysis revealed that IL-15 DCs exhibit a high expression of chemokines involved in antitumor immune effector cell attraction, while IL-4 DCs display a more immunoregulatory profile characterized by the expression of Th2 and regulatory T cell-attracting chemokines. This is confirmed by functional data indicating an enhanced recruitment of granzyme B+ effector lymphocytes by IL-15 DCs, as compared to IL-4 DCs, and subsequent superior killing of tumor cells by the migrated lymphocytes. Elevated CCL4 gene expression in IL-15 DCs and lowered CCR5 expression on both migrated γδ T cells and NK cells, led to validation of increased CCL4 secretion by IL15 DCs. Moreover, neutralization of CCR5 prior to migration resulted in an important inhibition of γδ T cell and NK cell recruitment by IL-15 DCs. These findings further underscore the strong immunotherapeutic potential of IL-15 DCs.