gebhart/patrepeval huggingface dataset:
A High Programmed Cell Death Protein 1 Hormone Receptor Score on Skin Biopsy is Associated with Sézary Syndrome Diagnosis: A Study of 91 Patients with Erythroderma (2022)

Erythroderma is challenging to diagnose. The aim of this single-centre retrospective study was to identify factors that can be used to improve the diagnosis of erythroderma. Among 91 patients with erythroderma, 21 were diagnosed with eczema, 17 with psoriasis, 20 with drug-induced erythroderma, 13 with erythrodermic mycosis fungoides and 20 with Sézary syndrome. Nail alterations, ear involvement, and severe scaling were significantly associated with psoriasis (p = 0.044). Fever and hypereosinophilia were associated with drug-induced erythroderma. Expression of programmed cell death protein 1 was observed in all skin biopsies. However, with Sézary syndrome, programmed cell death protein 1 expression was significantly higher than with other aetiologies. A programmed cell death protein 1 hormone receptor score (H-score) >50 was associated with Sézary syndrome (p < 0.001, sensitivity 75%, specificity 92%) as well as CXCL13 expression (p < 0.044). CD7 loss was more frequent with erythrodermic mycosis fungoides and Sézary syndrome (p = 0.022). This study reports the importance of programmed cell death protein 1 expression for the differential diagnosis of Sézary syndrome and other aetiologies, including erythrodermic mycosis fungoides.
Data management requirements (1977)

Memory management, database management, and message processing have in the past been defined in a relatively narrow way. With memory management the problem was to obtain cost effective use of real memory. Given a multiprogrammed environment, virtual memory systems allowed more effective use of expensive real memory. Memory management has become even more important with the development of very large and complex memory hierarchies. Database management systems were developed to allow the more effective use, sharing, and control of data resources - objectives which operating systems had previously provided for hardware resources. The driving force behind message processing has been the increased use of data communications and computer networks. This paper will consider the basis of the overlap in these areas, their common data management functions. Data management, as defined in this paper, includes the locating, routing, moving, and translating of data resources and the locating, reserving, and releasing of physical resources, i.e., primary and secondary storage.
Nucleophilic additions to ketenes by (trimethylsilyl)lithium and by enolates (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleophilic additions to ketenes by (trimethylsilyl)lithium and by enolatesLeyi Gong, Regis Leung-Toung, and Thomas T. TidwellCite this: J. Org. Chem. 1990, 55, 11, 3634–3639Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/jo00298a047https://doi.org/10.1021/jo00298a047research-articleACS PublicationsRequest reuse permissionsArticle Views889Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: PHTHALIMIDONITRENES. II. THE CIS‐ AND TRANS‐2,3‐DIMETHYL‐1‐PHTHALIMIDOAZIRIDINES. SYNTHESIS AND SOLVOLYSIS (1976)

Abstract Das nach bekannten Methoden erzeugte Nitren (III) liefert mit cis‐ (II) bzw. trans‐Buten (IV) stereospezifisch das cis‐ (I) (Invertomerengemisch) bzw. trans‐Dimethylaziridin (V) neben Phthalimid.
A Double-Blind Comparison of Ciprofloxacin and Amoxycillin/ Clavulanic Acid in the Treatment of Chronic Sinusitis (1994)

A total of 251 adults with chronic sinusitis were enrolled into this prospective multicentre, double-blind, double-placebo comparison of ciprofloxacin (500 mg twice daily) with amoxycillin/clavulanic acid (500 mg three times daily). The diagnosis of chronic sinusitis (persistence of clinical symptoms for at least 3 months) was confirmed by computerized tomography scan and/or sinusoscopy prior to therapy. Patients at inclusion had purulent or muco-purulent rhinorrhoea. Staphylococcus aureus (n = 45), Haemophilus influenzae (n = 35), Streptococcus pneumoniae (n = 32) and enterobacteriaceae (n = 31) were isolated from pre-treatment aspirates of the middle meatus. Treatment lasted 9 days, at the end of which nasal discharge disappeared in 71/118 (60.2%) patients of the ciprofloxacin group and 69/123 (56.1%) of those in the amoxycillin/clavulanic acid group. The clinical cure and bacteriological eradication rates were 58.6% versus 51.2% and 88.9% versus 90.5% for ciprofloxacin and amoxycillin/clavulanic acid, respectively. These differences were not significant, however, amongst patients who had a positive initial culture and who were evaluated 40 days after treatment. Ciprofloxacin recipients had a significantly higher cure rate than those treated with amoxycillin/clavulanic acid (83.3% vs. 67.6%, p = 0.043). Clinical tolerance was significantly better with ciprofloxacin (p = 0.012), essentially due to a large number of gastro-intestinal related side-effects in the amoxycillin/clavulanic acid group (n = 35). Ciprofloxacin proved to be at least as effective as amoxycillin/clavulanic acid. The superior safety profile, a twice daily dosage regimen, suggests that ciprofloxacin may be a useful therapeutic alternative for the treatment of chronic sinusitis.
Abstract 19812: Temporal Discordance of Atrial Fibrillation Burden With Major Bleeding and Intracranial Hemorrhage: Implications for Oral Anticoagulation Therapy (2016)

Introduction: In atrial fibrillation (AF), oral anticoagulation, which is taken daily without regard to pattern or presence of AF, categorically increases risk of major bleeding and intracranial he...
Theory of high-NA imaging in homogeneous thin films (1996)

A description is given of a modeling technique that is used to explore three-dimensional image distributions formed by high numerical aperture (NA &gt; 0.6) lenses in homogeneous, isotropic, linear, and source-free thin films. The approach is based on a plane-wave decomposition in the exit pupil. Factors that are due to polarization, aberration, object transmittance, propagation, and phase terms are associated with each plane-wave component. These are combined with a modified thin-film matrix technique in a derivation of the total field amplitude at each point in the film by a coherent vector sum over all plane waves. One then calculates the image distribution by squaring the electric-field amplitude. The model is used to show how asymmetries present in the polarized image change with the influence of a thin film. Extensions of the model to magneto-optic thin films are discussed.
In Vitro Antimicrobial Inhibition Profiles of Mycoplasma Bovis Isolates Recovered from Various Regions of the United States from 2002 to 2003 (2005)

Antimicrobial therapy continues to be important in reducing losses due to pneumonic forms of Mycoplasma bovis disease in beef and dairy calves. Although M. bovis diseases have been documented as frequent and economically important in the United States, there are no published reports on the antimicrobial activity of approved compounds against US strains. In this study, the authors report on the activity of 9 different antimicrobials against 223 recently recovered isolates of M. bovis. These isolates represent accessions from 5 geographic regions of the United States and were grouped by 4 tissues of origin (milk, respiratory, joint, or ear and eye). A broth microdilution test was used to determine minimum inhibitory concentration (MIC) values by reading redox changes detected in broth with alamarBlue (resazurin) indicator. For each antimicrobial, the median, MIC50, MIC90, mode, and range were calculated, and the values used for comparisons. In the absence of accepted breakpoint values, published MIC cutoff values for animal mycoplasmas as well as Clinical Laboratory Standards Institute interpretive criteria were used as a reference to define in vitro activity. The MIC values from active antimicrobials were found to distribute independently of region of origin of the isolates or of tissue of origin. Enrofloxacin, florfenicol, and spectinomycin were found to be active compounds in vitro. Oxytetracycline and chlortetracycline were active against more than half of the isolates. Very few isolates were inhibited by tilmicosin and none by erythromycin, ampicillin, or ceftiofur. The antimicrobial profiles determined for these US strains were remarkably similar to those reported for European isolates. However, unlike in Europe, there appears to be no diversity of profiles when US isolates are grouped by region or tissue of origin.
ChemInform Abstract: Total Synthesis of rac‐Silyhermin and Its 2‐Diastereomers of Potential Antihepatotoxic Activity. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Stem cell expansion: an initial step in functional tissue engineering (2004)

Ex vivo cell expansion represents a primary step in the road map of functional tissue engineering. Stem cells are frequently considered the optimal cell type for regenerative cell -based therapies; however they generally represent a small fraction of cells isolated from a biopsy or other cell source. We will present several aspects of expansion that must be considered; 1) the estimated expansion time to obtain the desired number of cells, 2) the changes of functional phenotype with expansion and 3) the possibility that during expansion, cells are brought closer to senescence or, conceivably, transformation. These are just some of the problems that bioengineers must address when stem cells are to be used in such functional regenerative therapies. Here we also present evidence suggesting that muscle-derived stem cells, which have undergone extensive expansion, have reduced ability, as compared to minimally expanded cells, to regenerate muscle in a murine mdx model for Duchenne Muscular Dystrophy.
Degree of Vinyl Conversion in Experimental Bioactive Composites (2008)

Objectives: The aim of this study was to asses the effect of resin composition and curing time on degree of vinyl conversion (DVC) attained in experimental composites based on amorphous calcium phosphate (ACP). Bioactivity of ACP composites instigates from their ability to release calcium and phosphate ions in aqueous ambience which may aid in arresting caries development. Methods: Experimental composites used in this study contained 35 mass % of zirconia-modified ACP filler and 65 mass % of either 2, 2-bis[p-(2'-hydroxy-3'-methacryloxypropoxy)phenyl]-propane (bis-GMA)-based or ethoxylated bisphenol A dimethacrylate (EBPADMA)-based resin. ACP powder and resins were thoroughly mixed and pressed under 107 Pa into composite disk specimens (thickness = 0.1 mm, diameter = 1.0 cm). The total of 32 samples (16/each experimental resin) were polymerized using soft start mode of Bluephase (Ivoclar Vivadent, Liechtenstein) LED curing unit for 20 s (8 samples/group) or 40 s (8 samples/group). The DVC was determined by Fourier Transform infrared spectroscopy (Perkin Elmer 2000 spectrometer ; Perkin Elmer, UK), as the % change in the ratio of the integrated peak areas between the aliphatic and aromatic absorption bands. Results: Statistical analysis of the experimental data (t-test) indicated that, when polymerized for 40s, EBPADMA-based composites have higher DVC than bis-GMA-based composites [(76.9 p 2.9) % vs. (74.2 p 1.8) % ; p<0.05]. However, no significant difference was found for the overall samples of each material if the polymerization time was not taken into account (p=0.76). Conclusions: Experimental ACP composites formulated with EPADMA as a base monomer have potential to attain higher degree of vinyl conversion compared to the composites based on Bis-GMA, a constituent of the majority of contemporary composites. This study was supported by grant 065-0352851-0410 of MZOS, Croatia.
Synthesis and characterization of the first trimetallic nitride templated pyrrolidino endohedral metallofullerenes (2005)

New pyrrolidino derivatives of both diamagnetic and paramagnetic trimetallic nitride templated endohedral metallofullerenes were synthesized by the Prato reaction, isolated and characterized by means of MALDI-TOF MS, NMR and UV-vis spectroscopies.
ChemInform Abstract: Enantioselective Deprotonation Reactions Using Polymer‐Supported Chiral Magnesium Amide Bases. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Using the Concept of Thin Dry Layer to Explain the Evolution of Thickness, Temperature, and Moisture Content during Convective Drying of Norway Spruce Boards (2005)

Abstract: This article presents an experimental device able to follow the wood temperature, moisture content, board thickness, and surface checking during convective drying. Tests have been carried out on Norway spruce (Picea abies) boards, with different sawing patterns and subjected to a more or less severe drying schedules. For some boards, we observed a first drying phase followed by a transient phase lasting several hours, during which the thickness reduces very slightly and the board temperatures depart from the wet bulb temperature. This period, which is not exactly a true constant drying rate period, can be analyzed using the concept of “thin dry shell.” In order to confirm our hypothesis, an analytical model was used and its results are compared with the experiment. This model takes into account external heat, mass transfer, and diffusion of heat and vapor between the exchange surface and the drying front. Very good agreement is obtained between calculated and experimental temperatures, which validates our equipment and brings physical explanations to different observed behavior; in particular, the existence of a transient first drying period with a thin dry layer is confirmed.
Towards understanding the power of quantum kernels in the NISQ era (2021)

A key problem in the field of quantum computing is understanding whether quantum machine learning (QML) models implemented on noisy intermediate-scale quantum (NISQ) machines can achieve quantum advantages. Recently, Huang et al. [Nat Commun 12, 2631] partially answered this question by the lens of quantum kernel learning. Namely, they exhibited that quantum kernels can learn specific datasets with lower generalization error over the optimal classical kernel methods. However, most of their results are established on the ideal setting and ignore the caveats of near-term quantum machines. To this end, a crucial open question is: does the power of quantum kernels still hold under the NISQ setting? In this study, we fill this knowledge gap by exploiting the power of quantum kernels when the quantum system noise and sample error are considered. Concretely, we first prove that the advantage of quantum kernels is vanished for large size of datasets, few number of measurements, and large system noise. With the aim of preserving the superiority of quantum kernels in the NISQ era, we further devise an effective method via indefinite kernel learning. Numerical simulations accord with our theoretical results. Our work provides theoretical guidance of exploring advanced quantum kernels to attain quantum advantages on NISQ devices.
On the Probability Density Function and Stability Properties for a Cross-Product Frequency-Locked Loop (2007)

The frequency locked-loop (FLL) has received new attention for modern Global Navigation Satellite Systems (GNSS) receivers, especially for its performance under severe noise interference and high dynamic environments. It has been shown that an FLL is more robust to interference and dynamics than a phase locked-loop (PLL). Therefore, it is beneficial to use an FLL as a fallback tracking loop when the primary PLL is unable to maintain carrier tracking in hostile environments. Besides tracking, it is to also crucial to preserve the Bit Error Rate (BER) of the data demodulation and probability of losing locks when receivers operate an FLL. These characteristics rely on the probability density function (PDF) of the frequency estimate made by the frequency discriminator in the FLL. However, the PDF has not been determined as of yet. The purpose of this paper is to solve the PDF and evaluate the stability region, which is essential for determining the statistics of loss of lock. In this work, a nonlinear model was developed and the corresponding Fokker-Planck equation (FPE) for the cross-product FLL was derived. The PDF of the frequency estimate was then solved by applying the Crank-Nicolson numerical method.
CoCoa: An Ontology for Cybersecurity Operations Centre Analysis Process (2018)

A cybersecurity operations centre ontology for analysis (CoCoa) is proposed, which aligns to the NIST cybersecurity framework. CoCoa is a process ontology for the CSOC analysis processes that provides the cybersecurity analysts operational situational awareness of the vital aspects of the CSOC. The process ontology offers a fundamental shift from log collection to the analysis of five overarching threat intelligence and information sources (namely - events and logs, network information, structured digital feed, semi and un-structured feed and threat intelligence), which should allow the CSOC to provide proactive monitoring, detection of inflight, emerging and complex threats that would not have ordinarily been detected through only events and logs. Further, and most importantly, the proposed ontology is then used to identify how cyber incidents can be realised and detected through ontology-based knowledge graph.
Parallel approaches to the segmentation of free-hand drawings (2002)

This paper describes the initial steps in the development of a parallel approach to the segmentation of free-hand drawings as part of a subject's neuropsychological assessment. The drawings to be segmented are responses to the widely used Rey-Osterrieth Complex Figure Test which comprises a number of simple geometric shapes such as rectangles and triangles with connecting lines. The need for a parallel approach in the segmentation of the drawings is discussed and a hierarchical solution proposed which reduces substantially the processing time required to perform the operation. Results are presented for a first approach to the segmentation and identification of substructures within the drawing based on a modified simple template matching algorithm. The results are promising but underline the complexity of segmenting such freehand line drawings.
Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding (2008)

The mechanism of denaturation of proteins by urea is explored by using all-atom microseconds molecular dynamics simulations of hen lysozyme generated on BlueGene/L. Accumulation of urea around lysozyme shows that water molecules are expelled from the first hydration shell of the protein. We observe a 2-stage penetration of the protein, with urea penetrating the hydrophobic core before water, forming a "dry globule." The direct dispersion interaction between urea and the protein backbone and side chains is stronger than for water, which gives rise to the intrusion of urea into the protein interior and to urea's preferential binding to all regions of the protein. This is augmented by preferential hydrogen bond formation between the urea carbonyl and the backbone amides that contributes to the breaking of intrabackbone hydrogen bonds. Our study supports the "direct interaction mechanism" whereby urea has a stronger dispersion interaction with protein than water.
Photosubstitution reactions of the ruthenium(II) arene complexes Ru(.eta.6-arene)L32+ (L = ammonia or water) in aqueous solution (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotosubstitution reactions of the ruthenium(II) arene complexes Ru(.eta.6-arene)L32+ (L = ammonia or water) in aqueous solutionWalter Weber and Peter C. FordCite this: Inorg. Chem. 1986, 25, 8, 1088–1092Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/ic00228a007https://doi.org/10.1021/ic00228a007research-articleACS PublicationsRequest reuse permissionsArticle Views425Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts