gebhart/patrepeval huggingface dataset:
Averaging Tail-Actuated Robotic Fish Dynamics Through Force and Moment Scaling (2015)

Averaging of robotic fish dynamics is of interest for the purposes of path planning and controller design due to the rhythmic movement of the robot. For a faithful dynamic model of robotic fish, however, classical averaging or geometric averaging typically cannot produce an average model that is accurate and in the meantime amenable to analysis or control design. In this paper, a novel averaging approach is proposed for tail-actuated robotic fish dynamics, in which the tail-generated hydrodynamic force is modeled with the Lighthill's large-amplitude elongated-body theory. The approach consists of scaling the force and moment terms and, then, conducting classical averaging. Numerical investigation reveals that the scaling function for the force term is a constant independent of tail-beat patterns, while the scaling function for the moment term depends linearly on the tail-beat bias. Extensive simulation and experimental results, comparing the predictions from the original and average models, are presented to support the effectiveness of the averaging approach. Existence and local stability of the equilibria for the average model are further analyzed. These equilibria are subsequently used to obtain an analytical solution for steady turning parameters, such as turning period and turning radius, without running simulation of the original or average dynamic models.
Mechanism of the Michaelis-Arbuzov Reaction: Olefin Formation (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of the Michaelis-Arbuzov Reaction: Olefin FormationALBERT Y. GARNER, EARL C. CHAPIN, and PATRICIA M. SCANLONCite this: J. Org. Chem. 1959, 24, 4, 532–536Publication Date (Print):April 1, 1959Publication History Published online1 May 2002Published inissue 1 April 1959https://pubs.acs.org/doi/10.1021/jo01086a023https://doi.org/10.1021/jo01086a023research-articleACS PublicationsRequest reuse permissionsArticle Views1040Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Behavior of Gas Injected Fast Ignition Targets (2022)

Gas target injection system is newly fabricated to observe behaviors of injected fast ignition targets. It can eject a mimic fast ignition target by pressured nitrogen gas and magnetic separator. The flight attitude of injected target is observed by high-speed cameras. Analysis of high-speed camera images indicates that the target velocity is increased with the injection gas pressure up to around 100 m/s which meets the demanded specification of a reactor and the target flight angle is varied in wide range shot by shot. The technical problem how to control flight angle is recognized for a fast ignition reactor.
Vaccines against human diarrheal pathogens (2014)

Worldwide, nearly 1.7 billion people per year contract diarrheal infectious diseases (DID) and almost 760 000 of infections are fatal. DID are a major problem in developing countries where poor sanitation prevails and food and water may become contaminated by fecal shedding. Diarrhea is caused by pathogens such as bacteria, protozoans and viruses. Important diarrheal pathogens are Vibrio cholerae, Shigella spp. and rotavirus, which can be prevented with vaccines for several years. The focus of this review is on currently available vaccines against these three pathogens, and on development of new vaccines. Currently, various types of vaccines based on traditional (killed, live attenuated, toxoid or conjugate vaccines) and reverse vaccinology (DNA/mRNA, vector, recombinant subunit, plant vaccines) are in development or already available. Development of new vaccines demands high levels of knowledge, experience, budget, and time, yet promising new vaccines often fail in preclinical and clinical studies. Efficacy of vaccination also depends on the route of delivery, and mucosal immunization in particular is of special interest for preventing DID. Furthermore, adjuvants, delivery systems and other vaccine components are essential for an adequate immune response. These aspects will be discussed in relation to the improvement of existing and development of new vaccines against DID.
Housing for People (1979)

The 'housing issue', the 'housing question', the 'housing problem': these terms and many more are bandied around freely by the providers of housing—central government, local authorities and housing associations—and campaigners for improvements and reform alike. They indicate, perhaps, only one thing: that despite all the concern and all the promises of recent years—and haven't there been plenty of both of those?—there still is a housing issue/question/problem. Certainly the mere fact that everybody uses the same terms should not be taken as any indication that there is a unity of view about the solutions needed or, less ambitiously, about the paths towards those solutions. Indeed, it is easy to get the impression—and many of the homeless people that I have been in contact with certainly have it—that the most important thing to many people is that they prove that their solutions are right.
Sodium hydrogen exchanger 9 NHE9 (SLC9A9) and its emerging roles in neuropsychiatric comorbidity (2020)

Variations in SLC9A9 gene expression and protein function are associated with multiple human diseases, which range from Attention-deficit/hyperactivity disorder (ADHD) to glioblastoma multiforme. In an effort to determine the full spectrum of human disease associations with SLC9A9, we performed a systematic review of the literature. We also review SLC9A9's biochemistry, protein structure, and function, as well as its interacting partners with the goal of identifying mechanisms of disease and druggable targets. We report gaps in the literature regarding the genes function along with consistent trends in disease associations that can be used to further research into treating the respective diseases. We report that SLC9A9 has strong associations with neuropsychiatric diseases and various cancers. Interestingly, we find strong overlap in SLC9A9 disease associations and propose a novel role for SLC9A9 in neuropsychiatric comorbidity. In conclusion, SLC9A9 is a multifunctional protein that, through both its endosome regulatory function and its protein-protein interaction network, has the ability to modulate signaling axes, such as the PI3K pathway, among others.
Toward realization of VICS - Vehicle Information and Communication System (1993)

The Japanese VICS (Vehicle Information and Communication System) conducts research on an information distribution system for drivers. It also continuously reviews the system. To make the results of its reviews widely understood by the public, the VICS Promotion Council undertook a demonstration in 1993. The demonstration is described, VICS's objectives and the reasons for its establishment are discussed, and the current status of its activities is described.
Supplementary Data from New Molecular and Biological Mechanism of Antitumor Activities of KW-2478, a Novel Nonansamycin Heat Shock Protein 90 Inhibitor, in Multiple Myeloma Cells (2023)

Supplementary Data from New Molecular and Biological Mechanism of Antitumor Activities of KW-2478, a Novel Nonansamycin Heat Shock Protein 90 Inhibitor, in Multiple Myeloma Cells
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells (1995)

A mismatch-binding heterodimer of hMSH2 and a 160-kilodalton polypeptide has been isolated from HeLa cells by virtue of its ability to restore mismatch repair to nuclear extracts of hMSH2-deficient LoVo colorectal tumor cells. This heterodimer, designated hMutS alpha, also restores mismatch repair to extracts of alkylation-tolerant MT1 lymphoblastoid cells and HCT-15 colorectal tumor cells, which are selectively defective in the repair of base-base and single-nucleotide insertion-deletion mismatches. Because HOT-15 cells appear to be free of hMSH2 mutations, this selective repair defect is likely a result of a deficiency of the hMutS alpha 160-kilodalton subunit, and mutations in the corresponding gene may confer hypermutability and cancer predisposition.
Electrostatic-Driven Lamination and Untwisting of β-Sheet Assemblies (2015)

Peptides or peptide conjugates capable of assembling into one-dimensional (1D) nanostructures have been extensively investigated over the past two decades due to their implications in human diseases and also their interesting applications as biomaterials. While many of these filamentous assemblies contain a β-sheet-forming sequence as the key design element, their eventual morphology could assume a variety of shapes, such as fibrils, ribbons, belts, or cylinders. Deciphering the key factors that govern the stacking fashion of individual β-sheets will help understand the polymorphism of peptide assemblies and greatly benefit the development of functional materials from customized molecular design. Herein, we report the decisive role of electrostatic interactions in the lamination and untwisting of 1D assemblies of short peptides. We designed and synthesized three short peptides containing only six amino acids (EFFFFE, KFFFFK, and EFFFFK) to elucidate the effective control of β-sheet stacking. Our results clearly suggest that electrostatic repulsions between terminal charges reduce the pitch of the twisting β-sheet tapes, thus leading to highly twisted, intertwined fibrils or twisted ribbons, whereas reducing this repulsion, either through molecular design of peptide with opposite terminal charges or through coassembly of two peptides carrying opposite charges, results in formation of infinite assemblies such as belt-like morphologies. We believe these observations provide important insight into the generic design of β-sheet assemblies.
A Modified Isomap Approach to Manifold Learning in Word Spotting (2015)

Word spotting is an effective paradigm for indexing document images with minimal human effort. Here, the use of the Bag-of-Features principle has been shown to achieve competitive results on different benchmarks. Recently, a spatial pyramid approach was used as a word image representation to improve the retrieval results even further. The high dimensionality of the spatial pyramids was attempted to be countered by applying Latent Semantic Analysis. However, this leads to increasingly worse results when reducing to lower dimensions. In this paper, we propose a new approach to reducing the dimensionality of word image descriptors which is based on a modified version of the Isomap Manifold Learning algorithm. This approach is able to not only outperform Latent Semantic Analysis but also to reduce a word image descriptor to up to $$0.12\,\%$$ of its original size without losing retrieval precision. We evaluate our approach on two different datasets.
Effects of inert gas dilution of silane on plasma-deposited a-Si:H films (1981)

Electrical, optical, and structural characterization of hydrogenated amorphous silicon films plasma-deposited from mixtures of SiH4 with different inert-gas diluents reveals substantial differences in a number of properties. A general trend of increasing defect density with atomic weight of the inert gas is observed. Of specific interest to device applications is the observation that high deposition rates can be achieved concurrently with low defect densities when helium is used as a deluent.
Cytomegalovirus DNA can be detected in peripheral blood mononuclear cells from all seropositive and most seronegative healthy blood donors over time (1998)

All seropositive donors harbored latently infected PBMNCs, as demonstrated by the testing of samples collected over time. In addition, a substantial proportion of seronegative individuals are CMV carriers and might transfer infection. The findings concur with clinical evidence of CMV transmission by blood components from seronegative individuals and with in vitro reactivation of CMV in PBMNCs from seronegative donors.
Is Blockchain Technology Suitable for Managing Personal Health Records? Mixed-Methods Study to Test Feasibility (2018)

This study confirms that it is possible to exchange PHR data in a private blockchain network. However, to develop a blockchain-based PHR platform that can be used in practice, many improvements are required, including reductions in data size, improved personal information protection, and reduced operating costs.
High-performance photonic analogue-digital converter (1997)

The authors demonstrate a photonic analogue-digital converter architecture based on temporal-spectral mapping. Linearily chirped optical pulses form a quasi-continuous carrier modulated by the analogue RF signal. The signal is separated into several distinct wavelength channels for parallel demodulation and quantisation. Measurements performed on 70 ps electrical signals indicate six bit resolution.
Control of Hormone Receptor Levels and Growth of 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors by Estrogens, Progesterone and Prolactin (1977)

The effect of various hormone treatments was investigated on the growth and hormone receptor levels of hormone-dependent (those which regressed after ovariectomy) dimethylbenz- (a)anthracene (DMBA)-induced mammary tumors in the rat. Hormone binding measured in die tumors which remained 5½ weeks after ovariectomy was low for estradiol-17β (E2) (0.6 ± 0.2 pmol/g tissue), R 5020 (0.9 ± 0.4 pmol/g tissue) and prolactin (PRL) (0.9 ± 0.4% of specific binding). In non-castrated animals, binding values were 2.9 ± 0.4 pmol/g tissue, 13.7 ± 2.0 pmol/g tissue and 3.2 ± 0.3% for E2, R 5020 and PRL, respectively. Administration of progesterone (P) alone (0.5 mg/day) for three weeks to castrated animals had no effect on tumor size or hormone binding. Treatment with E2 (0.5 μg/day) for the same period of time increased tumor size and hormone binding: E2, 3.0 ± 0.7 pmol/g tissue; R 5020, 14.8 ± 3.3 pmol/g tissue; PRL, 2.4 ± 0.6%. At a daily dose of 2 mg, PRL alone increased tumor size slightly while honnone binding remained low except for that of E2 which was increased to 2.0 ± 0.4 pmol/g tissue. Combination of E2 with P or PRL resulted in tumor growth greater than that observed after PRL or E2 alone. The levels of hormone binding present in the tumors at the end of these combined treatments were all increased to levels similar to those obtained with E2 alone. It can be concluded that the presence of estrogen receptors in the DMBA-induced mammary tumors is a veiy good index of hormone dependency. In fact, the levels of this receptor were high under all honnone treatments which led to stimulation of tumor growth. These studies also clearly demonstrate that the concentration of P receptors in the DMBAinduced mammary tumors, as well as the response of the tissue to P, depends upon E2.
Editorial (2010)

La convocatoria de medición de grupos de investigación tecnológica o de innovación realizada en Colombia en el año 2010, señala un incremento en el número de grupos de investigación en el país. Dichos datos coinciden con un mayor número de publicaciones en revistas indexadas, visibilizando el aumento de la calidad de la producción científica en el ámbito nacional. En esta ocasión la Universidad Libre, Sede Cartagena, logró la categorización de ocho grupos de investigación, resultado que demuestra el buen trabajo que los profesionales de esta universidad vienen desarrollando en los campos de la Jurisprudencia y las Ciencias Económicas, Administrativas y Contables. Un mecanismo para seguir propiciando estos buenos resultados es divulgar, en revisas especializadas, las investigaciones adelantadas en los diferentes grupos. La revista Saber Ciencia y Libertad, como órgano de difusión científica del Centro de Investigaciones de la Universidad Libre, Sede Cartagena, es una ventana abierta para la publicación de resultados de investigaciones desarrolladas en los diferentes grupos, y se ha consolidado como un espacio de divulgación de los docentes investigadores de la Sede Cartagena. Este último número publica doce trabajos cuya autoría corresponden, no solo a resultados de investigaciones adelantadas en los grupos de esta casa de estudios, sino a investigadores de otras universidades nacionales e internacionales quienes han confiado en la calidad y excelencia de esta publicación para dar a conocer los resultados alcanzados por las investigaciones desarrolladas en sus diferentes regiones. Dentro de este contexto, los investigadores aceptan el arbitraje de sus pares, quienes regulan el estándar en la publicación con el objeto de contribuir al avance del conocimiento. De esta manera, el comité editorial y los árbitros escogidos en cada edición, se constituyen en filtros que garantizan la calidad de los artículos publicados, a fin de alcanzar un mayor reconocimiento a nivel nacional e internacional. Es así, que en esta ocasión nos acompañan prestigiosos pares internacionales de universidades en Canadá, Cuba, Argentina y, a nivel nacional, de la Escuela Naval Almirante Padilla, Colciencias y de la Universidad Libre de Colombia. La ciencia es universal, de igual manera hoy lo es su difusión. Confiamos en que los artículos publicados en la presente edición se constituyan en un elemento de valiosa consulta y que contribuyan al desarrollo de la ciencia, que cuenta entre sus características, el tener una línea transversal en la evolución del ser humano.
Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during checkpoint blockade (2022)

Single-cell RNA sequencing data and TCR data from "Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during checkpoint blockade", Berner et al.
Abstract 11828: Contemporary Temporal Trends in Cardiovascular Events Among Elderly Patients Hospitalized With Autoimmune Disorders and Concomitant Recreational Cannabis Use (2022)

Background: The role of Cannabis in autoimmune diseases (AD) has been previously discussed due to its anti-inflammatory properties, however, cardiovascular events in elderly patients with AD are not well studied with habitual recreational cannabis usage or cannabis use disorder (CUD). Methods: We queried the National Inpatient Sample (2016-2019) for geriatric AD patients with vs. without CUD. Propensity score-matched analysis (1:1) was used to compare comorbidities, major adverse cardiac and cerebrovascular events [MACCE: all-cause mortality, acute myocardial infarction (AMI), cardiac arrest and acute ischemic stroke (AIS)], and healthcare resource utilization in the CUD vs. non-CUD cohort with AD. Results: Of 11350 elderly admissions with AD, propensity-matched cohorts consisted of 5675 patients with CUD (49.1% male) and without CUD (26.7% male). Both groups had comparable ages (median 69 years), racial groups (&gt;70% white), and income quartiles. CUD cohort showed higher rates of hypertension, PVD, smoking, alcohol abuse, drug abuse, depression, and prior MI (p&lt;0.005) compared to the non-CUD cohort. The CUD cohort had higher rate of transfers to other care facilities (2.6% vs. 1.9%, p≤0.001), prolonged hospital stays, and higher cost, the adjusted odds were not significant for MACCE (OR 1.22, 95%CI 0.88-1.69, p=0.24), all-cause mortality (OR 0.74, 95%CI 0.37-1.46, p=0.34), AMI (OR 1.52, 95%CI 0.95-2.43, p=0.08), AIS (OR 1.19, 95%CI 0.69-2.17, p=0.57), or cardiac arrest (OR 1.34, 95%CI 0.55-3.26, p=0.51), compared to non-CUD elderly AD cohort. The CUD cohort often had routine discharges (52.7% vs. 47.4%, p≤0.001) compared to the non-CUD cohort. Conclusions: This nationwide propensity-matched analysis did not reveal worse cardiovascular outcomes in older AD patients with CUD. Future large-scale prospective studies are needed to validate these findings and evaluate the long-term effects of medicinal/recreational cannabis usage in these individuals.
Metrics of Scholarly Impact (2012)

Assessments of scientific contribution are important for a variety of reasons. For individuals early in their career, metrics of scientific work can provide valuable feedback about where they stand...
Efficient methods for filtering and ranking fragments for the prediction of structurally variable regions in proteins (2003)

The prediction of protein 3D structures close to insertions and deletions or, more generally, loop prediction, is still one of the major challenges in homology modeling projects. In this article, we developed ranking criteria and selection filters to improve knowledge-based loop predictions. These criteria were developed and optimized for a test data set containing 678 insertions and deletions. The examples are, in principle, predictable from the used loop database with an RMSD < 1 A and represent realistic modeling situations. Four noncorrelated criteria for the selection of fragments are evaluated. A fast prefilter compares the distance between the anchor groups in the template protein with the stems of the fragments. The RMSD of the anchor groups is used for fitting and ranking of the selected loop candidates. After fitting, repulsive close contacts of loop candidates with the template protein are used for filtering, and fragments with backbone torsion angles, which are unfavorable according to a knowledge-based potential, are eliminated. By the combined application of these filter criteria to the test set, it was possible to increase the percentage of predictions with a global RMSD < 1 A to over 50% among the first five ranks, with average global RMSD values for the first rank candidate that are between 1.3 and 2.2 A for different loop lengths. Compared to other examples described in the literature, our large numbers of test cases are not self-predictions, where loops are placed in a protein after a peptide loop has been cut out, but are attempts to predict structural changes that occur in evolution when a protein is affected by insertions and deletions.
Conversion of the BNL 200 MeV Linac to H/sup -/ and polarized H/sup -/ acceleration (1984)

Planning for the conversion of the AGS Linac to H/sup -/ acceleration was begun in 1979; installation was completed in 1983. Discussion of this work and of the operational experience will be presented. The AGS Polarized Beam Project was begun in 1980. The design of the new H/sup -/ polarized source, the low Energy Beam Transport line (LEBT), and Radio-Frequency Quadrupole (RFQ) will be described. Current status and future plans will be presented. 14 references, 5 figures.
ChemInform Abstract: Sulfur Dioxide Gas Detection with Na2SO4 (1986)

Abstract Y 2 (SO 4 ) 3 ‐ SiO 2 Solid Electrolyte by a Solid Reference Electrode Method.