gebhart/patrepeval huggingface dataset:
Hfq Virulence Regulation in Enterohemorrhagic Escherichia coli O157:H7 Strain 86-24 (2011)

Enterohemorrhagic Escherichia coli O157:H7 (EHEC) causes bloody diarrhea and hemolytic-uremic syndrome. EHEC encodes the sRNA chaperone Hfq, which is important in posttranscriptional regulation. In EHEC strain EDL933, Hfq acts as a negative regulator of the locus of enterocyte effacement (LEE), which encodes most of the proteins involved in type III secretion and attaching and effacing (AE) lesions. Here, we deleted hfq in the EHEC strain 86-24 and compared global transcription profiles of the hfq mutant and wild-type (WT) strains in exponential growth phase. Deletion of hfq affected transcription of genes common to nonpathogenic and pathogenic strains of E. coli as well as pathogen-specific genes. Downregulated genes in the hfq mutant included ler, the transcriptional activator of all the LEE genes, as well as genes encoded in the LEE2 to -5 operons. Decreased expression of the LEE genes in the hfq mutant occurred at middle, late, and stationary growth phases. We also confirmed decreased regulation of the LEE genes by examining the proteins secreted and AE lesion formation by the hfq mutant and WT strains. Deletion of hfq also caused decreased expression of the two-component system qseBC, which is involved in interkingdom signaling and virulence gene regulation in EHEC, as well as an increase in expression of stx(2AB), which encodes the deadly Shiga toxin. Altogether, these data indicate that Hfq plays a regulatory role in EHEC 86-24 that is different from what has been reported for EHEC strain EDL933 and that the role of Hfq in EHEC virulence regulation extends beyond the LEE.
Atherothrombosis: role of tissue factor; link between diabetes, obesity and inflammation. (2007)

Atherothrombotic vascular disease is a complex disorder in which inflammation and coagulation play a pivotal role. Rupture of high-risk, vulnerable plaques with the subsequent tissue factor (TF) exposure is responsible for coronary thrombosis, the main cause of unstable angina, acute myocardial infarction, and sudden cardiac death. Tissue factor (TF), the key initiator of coagulation is an important modulator of inflammation. TF is widely expressed in atherosclerotic plaques and found in macrophages, smooth muscle cells, extracellular matrix and acellular lipid-rich core. TF expression can be induced by various stimulants such as C-reactive protein, oxLDL, hyperglycemia and adipocytokines. The blood-born TF encrypted on the circulating microparticles derived from vascular cells is a marker of vascular injury and a source of procoagulant activity. Another form of TF, called alternatively spliced has been recently identified in human and murine. It is soluble, circulates in plasma and initiates coagulation and thrombus propagation. Evidence indicates that elevated levels of blood-borne or circulating TF has been associated with metabolic syndrome, type 2 diabetes and cardiovascular risk factors and is a candidate biomarker for future cardiovascular events. Therapeutic strategies have been developed to specifically interfere with TF activity in the treatment of cardiovascular disease.
On the Relation between Lattice-Reduction-Aided Equalization and Partial-Response Signaling (2006)

Equalization for channels with intersymbol interference is studied. In particular, we show that the well-known technique of partial-response signaling is the analogon to lattice-reduction-aided equalization of MIMO channels. An algorithm for factorizing the channel transfer function, replacing the lattice reduction in MIMO channels, is derived. It is shown that the proposed schemes offer a good trade-off between complexity and performance. Especially, precoding the partial-response part is worthwhile; only limited channel-state information at the transmitter is required and channel coding can be applied immediately
Clinical-scale radiolabeling of a humanized anticarcinoembryonic antigen monoclonal antibody, hMN-14, with residualizing 131I for use in radioimmunotherapy. (2005)

Efficient removal of (131)I-IMP-R4 and quenched (131)I by 5 min of stirring with anion-exchange resin renders a multi-gigabecquerel-level preparation of (131)I-IMP-R4-hMN-14 safe, convenient, and practical.
Abdominal undifferentiated small round cell tumor with unique translocation (X;19)(q13;q13.3) (2010)

We describe a male with a large abdominal mass, most likely originating from the liver, with capsule rupture and tumor dissemination into the abdominal cavity. Adherence of the tumor to the diaphragm and lower right colon also were noted. A comprehensive evaluation of the mass revealed no tumor-defining histopathologic, immunocytochemical, ultrastructural, cytogenetic, or translocation features. The malignant tumor was found to have a novel translocation (X;19)(q13;13.3), which has not been reported in small round cell tumors of childhood or adults. The final diagnosis rendered was an undifferentiated small round cell tumor of uncertain cell of origin.
1049 EMG ANALYSIS OF THE QUADRICEPS AND HAMSTRINGS DURING GRADED TREADMILL EXERCISE ON TWO DIFFERENT SURFACES (1994)

Lange, G. W.; Hintermeister, R. A.; Schlegel, T.; Dillman, C. J.; Steadman, J. R. Author Information
Numerical Analysis of Carbon Dioxide Separation by Pressure Swing Adsorption. (1995)

粒状MSCを吸着分離材とするPSA法によるCO2/N2系2成分混合ガスからのCO2分離濃縮操作について数理モデルによる数値解析を行い, CO2分離濃縮性能に関する既往の実験結果との比較に基づいて本解析法の妥当性を検討するとともに, 吸着材充填層内の気相および固相中のCO2, N2濃度を計算し, 両成分の吸・脱着挙動を調べた.また, CO2の高濃度分離に関して実験および数値解析の両面から検討を加えた.その結果, 1) 本CO2-PSA操作の解析結果は実験結果と概ね一致し, 本解析法の妥当性が示され, CO2分離濃縮性能をLangmuir多成分吸着平衡および単成分拡散係数によって統一的に説明できること, 2) 本解析法により, 吸着材充填層内におけるCO2, N2の吸・脱着挙動が定量的に把握できること, 3) 本CO2-PSAにおいて多段PSA処理法あるいは還流操作を加えることによりCO2の高濃度分離が可能になること, などが示された.
The birth of the Internet printing protocol (IPP) (1998)

article The birth of the Internet printing protocol (IPP) Share on Author: Carl-Uno Manros Xerox Corp., El Segundo, CA Xerox Corp., El Segundo, CAView Profile Authors Info & Claims StandardViewVolume 6Issue 4Dec. 1998 pp 135–139https://doi.org/10.1145/338183.338184Online:01 December 1998Publication History 0citation899DownloadsMetricsTotal Citations0Total Downloads899Last 12 Months5Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Numerical solution of the compressible boundary layer equations using the finite element method (1992)

We study the application of the finite element method (FEM) to the boundary-layer equations governing both incompressible (with heat transfer) and compressible fluids in two dimensions. Numerical solutions for this set of equations have traditionally been obtained using the finite difference method (FDM), where the derivatives are approximated by difference quotients resulting in an algebraic representation of the partial differential equations. In FEM, the flow region is subdivided into a number of small regions called finite elements, and the dependent variables are interpolated within each element by functions of compatible order
Towards lens-based wavefront sensorless adaptive optics full-field OCT for in-vivo retinal imaging (Conference Presentation) (2019)

Full-Field Optical Coherence Tomography (FF-OCT) offers aberration independent resolution. This inherent property makes FF-OCT a promising imaging modality for 3D high-resolution retinal imaging. Nevertheless, ocular aberrations affect signal reduction, imposing Adaptive Optics. Here we investigate the best strategy to compensate for ocular aberrations in our FF-OCT setup, in terms of wavefront measurement and correction. The use of wavefront sensorless approach based on the FF-OCT signal level is investigated. Moreover, a strategy of static wavefront correction in a non-conjugated pupil plane and next to the eye’s pupil, just like spectacles, favoring a compact and non-complex AO design, is also investigated. Additionally, the use of wavefront corrector devices such as an adaptive liquid lens (correcting to defocus and astigmatism) and multi-actuator adaptive lenses (correcting up to the 4th order Zernike polynomial) are evaluated. Finally, we expect the implementation of one or a combination of the studied strategies into our FF-OCT setup to lead to the first in-vivo retinal images obtained using AO-assisted FF-OCT, for different retinal layers with enhanced SNR and a 3D high-resolution.
Development of Natural Fibre-Reinforced Semi-Finished Products with Bio-Based Matrix for Eco-Friendly Composites (2022)

Increasing resource consumption and a growing amount of textile waste increase the importance of a circular economy and recycling in the fashion and apparel industry. Environmentally friendly bio-based composites made from cellulosic fibres obtained from textile waste, and polymers based on renewable raw materials present a possible solution. In this study, the development of textile semi-finished products based on medium-to-long cotton and flax fibres obtained from textile waste in combination with a bio-based thermoplastic matrix for lightweight applications is investigated. For the production of natural fibre-polylactide hybrid yarns, fibre slivers with improved fibre orientation and blending are produced. Subsequently, quasi-unidirectional woven fabrics are produced and consolidated into bio-based composites. Textile and mechanical properties of hybrid yarns as well as bio-composites are analysed with regard to the influence of fibre length, fibre distribution in the yarn, yarn structure and fibre volume content. The results show that the production of bio-based semi-finished products can be a potential way for upcycling textile waste.
Flavin analog studies of pig kidney general acyl-CoA dehydrogenase (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFlavin analog studies of pig kidney general acyl-CoA dehydrogenaseColin Thorpe and Vincent MasseyCite this: Biochemistry 1983, 22, 12, 2972–2978Publication Date (Print):June 7, 1983Publication History Published online1 May 2002Published inissue 7 June 1983https://pubs.acs.org/doi/10.1021/bi00281a029https://doi.org/10.1021/bi00281a029research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Scheduling algorithms for input-queued cell switches (1996)

The algorithms described in this thesis are designed to schedule cells in a very high-speed, parallel, input-queued crossbar switch. We present several novel scheduling algorithms that we have devised, each aims to match the set of inputs of an input-queued switch to the set of outputs more efficiently, fairly and quickly than existing techniques. In Chapter 2 we present the simplest and fastest of these algorithms: SLIP --- a parallel algorithm that uses rotating priority (&amp;quot;round-robin&amp;quot;) arbitration. SLIP is simple: it is readily implemented in hardware and can operate at high speed. SLIP has high performance: for uniform i.i.d. Bernoulli arrivals, SLIP is stable for any admissible load, because the arbiters tend to desynchronize. We present analytical results to model this behavior. However, SLIP is not always stable and is not always monotonic: adding more traffic can actually make the algorithm operate more efficiently. We present an approximate analytical model of this behavior. SLIP prevents starvation: all contending inputs are eventually served. We present simulation results, indicating SLIP&amp;apos;s performance. We argue that SLIP can be readily implemented for a 32x32 switch on a single chip. In Chapter 3 we present i-SLIP, an iterative algorithm that improves upon SLIP by converging on a maximal size match. The performance of i-SLIP improves with up to log 2 N iterations. We show that although it has a longer running time than SLIP, an i-SLIP scheduler is little more complex to implement. In Chapter 4 we describe maximum or maximal weight matching algorithms based on the occupancy of queues, or waiting times of cells. These algorithms are stabl...
The Mechanism of Elimination Reactions. I. The Decomposition of Quaternary Ammonium Bases and of Xanthate Esters1 (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Mechanism of Elimination Reactions. I. The Decomposition of Quaternary Ammonium Bases and of Xanthate Esters1Philip G. Stevens and James H. RichmondCite this: J. Am. Chem. Soc. 1941, 63, 11, 3132–3136Publication Date (Print):November 1, 1941Publication History Published online1 May 2002Published inissue 1 November 1941https://pubs.acs.org/doi/10.1021/ja01856a070https://doi.org/10.1021/ja01856a070research-articleACS PublicationsRequest reuse permissionsArticle Views283Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chemical Constituents from the Seeds of <I>Morinda citrifolia</I> (2009)

AIM: To investigate the chemical constituents of the seeds of M. citrifolia. METHODS: The chemical constituents from the seed of M. citrifolia were separated and purified by silica gel, Rp-18, Sephadex LH-20 column chromatography and Pre-TLC. Their structures were elucidated on the basis of extensive spectroscopic analysis (including 2D NMR). RESULTS: Twenty known compounds were identified as daucosterol (1), ursolic acid (2), 19-hydroxyl-ursolic acid (3), 1, 5, 15-trimethylmorindol (4), 5, 15-dimethyl-morindol (5), scopoletin (6), 3, 3'-bisdemethylpinoresinol (7), 3, 4, 3' 4'-tetrahydroxy-9, 7'a-epoxylignano-7'a, 9'-lactone (8), americanin D (9), americanin A (10), americanin (11), isoprincepin (12), deacetyl-asperulosidic acid (13), loganic acid (14), asperulosidic acid (15), rhodolatouside (16), quercetin-3-O-α-L- rhamnopyranosyl-(1→6)-β-D-glucopyranoside (17), 4-ethyl-2-hydroxyl-succinate (18), 5-hydroxymethyl-2-furancarbox-aldehyde (19), 3-methylbut-3-enyl-6-O-β-D-glucopyranosyl-β-D-glucopyranoside (20). CONCLUSION: Compounds 9, 11, 14, 16 and 18 are reported from M. citrifolia for the first time.
A matched filter detection system for complicated Doppler shifted signals (1960)

A matched filter system is described which was designed to detect complicated signals subject to a wide range of possible Doppler shifts. A 100 tap band-pass delay line was used in conjunction with a resistor weighting matrix to synthesize signals and filter characteristics. The system could handle a signal with a duration-bandwidth product of 100 over a range of Doppler frequency shifts 17 times the reciprocal of the signal duration. A theoretical discussion of the Doppler effect is given, making use of conjugate functions or Hilbert Transforms. Various engineering compromises which simplify the construction of matched filters are suggested. The performance of the resulting signal detection system was within 5 db of that of an ideal theoretical model.
Characterization of iodoheptafluoropropane as a dielectric etchant. I. Process performance evaluation (2001)

1- and 2-iodoheptafluoropropane were characterized extensively as potential replacement etchants for perfluorocompounds used in an oxide etch application. In the present study, via holes of critical dimension down to 0.35 μm were etched in an inductively coupled high density plasma tool. Oxide etch rate, mask and stop layer selectivities, and feature profile were among the principal metrics used to evaluate the performance of these compounds. A conventional (C3F8-based) etch process was used as a reference. Process behavior as a function of a number of variables—namely source power, bias power, etch gas flow, additive gas CH3F) flow, roof, wall, and chiller temperatures, and pressure was studied. While good etch rates and feature profiles were obtained, mask and stop layer selectivity was found to be limited. As a supplement to the experimental work, a set of ab initio quantum chemical calculations was undertaken to obtain enthalpies of dissociation for each of the bonds in the iodoheptafluoropropane molecules in order to better understand their dissociation pathways in plasma environments. Part I focuses on trends in process behavior as a function of the variables explored and discusses key mechanisms responsible for the observed effects. Parts II and III will focus on deposited film characterization and global warming emissions, respectively.
Novel Therapeutic Options due to Autologous Blood Components – Exemplified by Autologous Platelet Gel (2006)

Autologous platelet gel (APG) was developed in the early 1970s as a byproduct of the so-called multi-component apheresis. APG is a matrix composed of fibrin and platelets, and was initially used as a wound sealing. Due to the effects of both thrombin and calcium, the platelets aggregates,resulting in a release of several growth factors. There is clinical evidence that the growth factors released enhance wound healing by stimulating tissue vascularity due to an increased rate of angiogenesis. Apart from that, APG acts hemostatic and causes a lymphatic sealing. This effect leads to less seroma and thus to less pain postoperatively. The intraoperative production of APG for local application and as source of growth factors which serves as promoters of wound healing is part of the perioperative autologous hemotherapy and has to meet the legal regulations in Germany. The 12th amendment of the German Drug Law and the latest revision of the German Transfusion Act have aggravated the legal requirements for the production and application of autologous blood products. It is predominant regarding the legal question whether or not one has to account those procedures as drug production in accordance to the German Drug Law. If one has to account, it is quite obvious that most of the German hospitals cannot meet the legal requirements of an intraoperative drug production. Because the German legislator has so far not defined a clear legal frame for novel perioperative autologous blood products, this could lead to the end of use of those techniques in our clinical routine. Thus, leading to the situation that no ‘evidence class 1 study’ will be conducted in order to investigate safety and efficacy of these novel procedures. The concept of the ‘near patient unit’ is new and therefore clinically not yet established. For perioperative autologous hemotherapy this concept defines the minimum legal requirements for a safe production and application of autologous blood products, outside of the scope of both, the German Drug Law and the German Transfusion Act, but still in accordance with the most recent guidelines on hemotherapy,as published by the Federal Medical Association (Bundesärztekammer). The legal end points are: no distribution to a third party, a strict personal identity for the production and application, exertion only by qualified persons, and an immediate connection to the planned operation as part of the method. The German legislator should modify both, the German Drug Law and German Transfusion Act in a way, to provide a legal certainty for the use of the perioperative hemotherapy.
Obstructive Sleep Apnea Is Independently Associated with Insulin Resistance (2002)

Epidemiological studies have implicated obstructive sleep apnea (OSA) as an independent comorbid factor in cardiovascular and cerebrovascular diseases. It is postulated that recurrent episodes of occlusion of upper airways during sleep result in pathophysiological changes that may predispose to vascular diseases. Insulin resistance is a known risk factor for atherosclerosis, and we postulate that OSA represents a stress that promotes insulin resistance, hence atherogenesis. This study investigated the relationship between sleep-disordered breathing and insulin resistance, indicated by fasting serum insulin level and insulin resistance index based on the homeostasis model assessment method (HOMA-IR). A total of 270 consecutive subjects (197 male) who were referred for polysomnography and who did not have known diabetes mellitus were included, and 185 were documented to have OSA defined as an apnea-hypopnea index (AHI) > or =5. OSA subjects were more insulin resistant, as indicated by higher levels of fasting serum insulin (p = 0.001) and HOMA-IR (p < 0.001); they were also older and more obese. Stepwise multiple linear regression analysis showed that obesity was the major determinant of insulin resistance but sleep-disordered breathing parameters (AHI and minimum oxygen saturation) were also independent determinants of insulin resistance (fasting insulin: AHI, p = 0.02, minimum O(2), p = 0.041; HOMA-IR: AHI, p = 0.044, minimum O(2), p = 0.022); this association between OSA and insulin resistance was seen in both obese and nonobese subjects. Each additional apnea or hypopnea per sleep hour increased the fasting insulin level and HOMA-IR by about 0.5%. Further analysis of the relationship of insulin resistance and hypertension confirmed that insulin resistance was a significant factor for hypertension in this cohort. Our findings suggest that OSA is independently associated with insulin resistance, and its role in the atherogenic potential of sleep disordered breathing is worthy of further exploration.