gebhart/patrepeval huggingface dataset:
High yield synthesis of cis-dihydrido-trans-bis(phosphite)dicarbonyliron complexes H2Fe(CO)2[P(OR)3]2 (R = Me, Et, Ph) (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh yield synthesis of cis-dihydrido-trans-bis(phosphite)dicarbonyliron complexes H2Fe(CO)2[P(OR)3]2 (R = Me, Et, Ph)Jean Jacques Brunet, Fadjai Banda Kindela, Daniel Labroue, and Denis NeibeckerCite this: Inorg. Chem. 1990, 29, 20, 4152–4153Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://pubs.acs.org/doi/10.1021/ic00345a049https://doi.org/10.1021/ic00345a049research-articleACS PublicationsRequest reuse permissionsArticle Views111Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Unravelling the Metastable Nature of the Single Site Tungsten Hydride Metathesis Catalyst Supported on γ-Alumina from First Principles (2018)

We explore the structure and formation mechanism of the surface tungsten hydride complex supported on alumina, which is a catalyst for alkane and alkene metathesis and cross-metathesis. We show that the kinetics for the formation reaction of the hydride from the grafted alkylidyne–alkyl W complex strongly favors the creation of a metastable Wⱽᴵ trihydride, which is less coordinated by the alumina surface than the most stable isomer. The reaction network for the hydride formation involves hydrogenation of the W≡C or W═C bond, hydrogenolysis of W–C bonds, and a second grafting step. The creation of metastable surface complexes is proposed to be a key path for the design of active and selective catalysts.
Cross Validation of Luminex Platforms from Two Vendors to Detect and Quantify HLA Antibodies Using Single Antigen Assay Results from 7 CTOT Core Laboratories (2012)

Aims: Luminex-based assays to detect and quantify HLA antibodies are used to evaluate risks of allograft rejection and monitor immune responses following transplantation. The purpose of this study was to assess agreement in predictions for the presence of HLA antibodies in sera using median fluorescence intensity (MFI) values obtained from 7 centers testing single antigen assay kits from two vendors (A and B). Methods: Following adoption of standardized SOPs, reference sera were sent together with identical lots of reagents to 7 centers across North America. Two single antigen kits (Class I&II) per vendor were analyzed using 14-16 sera samples depending on kit type. For each bead/serum combination (n = 5,236), one vendor's data and software was used to establish truth, then the second vendor's reactions on beads carrying the same antigen were tested for agreement via receiver operating characteristic (ROC) analysis. Vendor roles were reversed, and the analysis was repeated. Results:Figure 1 shows four panels of ROC curves grouped according to kit type (HLA Class I/II) and vendor (A/B). In general, areas under the ROC curves ranged from 0.89 to 0.98 (with standard errors < 0.02) across centers (gray lines) and kits (black lines). When Vendor B's data established truth, Vendor A's ability to correctly classify reactions was optimized with MFI cutoffs of 1400 units, yielding sensitivity/specificity/accuracy values of 69%/97%/91% and 75%/94%/90% for Class I and II kits, respectively. When testing Vendor B against Vendor A, the optimal MFI cutoff was 3100 units with sensitivity/specificity/accuracy values of 92%/96%/95% and 74%/97%/92% for Class I and II kits, respectively.[Fig. 1]Conclusions: The differences among the centers were small and inconsequential, and the overall consistency in antibody assignments between vendors was excellent at the antigen level. The study represents an important step to validate the reproducibility of the HLA antibody Luminex results.
Mutations in Pneumococcal cpsE Generated via In Vitro Serial Passaging Reveal a Potential Mechanism of Reduced Encapsulation Utilized by a Conjunctival Isolate (2015)

While the capsule of Streptococcus pneumoniae is required for colonization and invasive disease, most conjunctival isolates are acapsular by virtue of deletion of the entire capsular operon. We show that spontaneous acapsular mutants isolated in vitro harbor mostly nonrevertible single nucleotide polymorphism (SNP) null mutations in cpsE, encoding the initiating glycosyltransferase. From a small collection of acapsular conjunctival isolates, we identified one strain with a complete capsular operon but containing a SNP in cpsE that we show is responsible for the acapsular phenotype. We propose that acapsular conjunctival isolates may arise initially from such nonreverting SNP null mutations in cpsE, which can be followed later by deletion of portions or all of the cps operon.
Transcription factor redundancy and tissue-specific regulation: Evidence from functional and physical network connectivity (2012)

Two major transcriptional regulators of Caenorhabditis elegans bodywall muscle (BWM) differentiation, hlh-1 and unc-120, are expressed in muscle where they are known to bind and regulate several well-studied muscle-specific genes. Simultaneously mutating both factors profoundly inhibits formation of contractile BWM. These observations were consistent with a simple network model in which the muscle regulatory factors drive tissue-specific transcription by binding selectively near muscle-specific targets to activate them. We tested this model by measuring the number, identity, and tissue-specificity of functional regulatory targets for each factor. Some joint regulatory targets (218) are BWM-specific and enriched for nearby HLH-1 binding. However, contrary to the simple model, the majority of genes regulated by one or both muscle factors are also expressed significantly in non-BWM tissues. We also mapped global factor occupancy by HLH-1, and created a genetic interaction map that identifies hlh-1 collaborating transcription factors. HLH-1 binding did not predict proximate regulatory action overall, despite enrichment for binding among BWM-specific positive regulatory targets of hlh-1. We conclude that these tissue-specific factors contribute much more broadly to the transcriptional output of muscle tissue than previously thought, offering a partial explanation for widespread HLH-1 occupancy. We also identify a novel regulatory connection between the BWM-specific hlh-1 network and the hlh-8/twist nonstriated muscle network. Finally, our results suggest a molecular basis for synthetic lethality in which hlh-1 and unc-120 mutant phenotypes are mutually buffered by joint additive regulation of essential target genes, with additional buffering suggested via newly identified hlh-1 interacting factors.
Quality Control Test Device for the Roscoby RiserCam (2008)

Final report for Team 6 of ME450, Fall 2008 semester.
[Urinary Corynebacterium group D2 infections. A hospital epidemic and antibiotic sensitivity]. (1988)

An outbreak of Corynebacterium group D2 urinary tract infections was recently observed at Nice CHR. These infections were characterized by alkaline urine. The five first cases were reported in the same department and the ten other cases were latter observed in different departments. Age average was 79 and all patients had either an intra-vesical catheter of a urinary collector. Among samples of material tested, only one gave a positive culture. The 15 isolates showed a similar identification and antibiotic phenotype. These strains presented a multiple antibiotic resistance: resistance to beta-lactams, aminoglycosides (except streptomycin), erythromycin, chloramphenicol, tetracyclines. All strains were susceptible to rifampin, pristinamycin, fusidic acid and vancomycin.
[PL‐03–02–01]: THE FUTURE OF ELECTRONIC HEALTH RECORDS AND BIG DATA IN DEMENTIA RESEARCH (2017)

Clearly Alzheimer's Disease is a very big problem. Might Big Data provide something of a solution or is it a big, albeit fashionable, distraction? Will Big Data – whether derived from high dimensionality biological datasets or from real world clinical data derived from Electronic Health Records - help progress the search for therapeutic interventions in dementia? The opportunities are considerable; Big Data has after all transformed many other fields ranging from social media to shopping and has long been heralded as a potentially disruptive technology in clinical medicine. Some evidence of these opportunities being realised in dementia research will be highlighted, and some platforms offering Big Data opportunities including the European Medical Information Framework (www.emif.eu) and Dementias Platform UK (www.dementiasplatform.uk) will be discussed. The challenges, technical and ethical, are not inconsiderable but the future of Big Data research in dementia, especially with the power of connected devices, looks set to be one of growing importance.
Advances in 3D data acquisition, mapping and localization in modern large-scale warehouses (2014)

Today modern manufacturing and logistic processes rely in most instances on manual forklifts. Being known for low efficiency, high energy consumption and listed among the most frequent causes of severe accidents in factories, the SICK AG coordinated EU funded research project PAN Robots aims to replace them in large scale with Automated Guided Vehicles (AGV). One major obstacle for operators with current AGVs are high installation cost for localization-supporting infrastructure, e.g. reflectors and manual measurement which needs to be performed by highly trained professionals in order to create an accurate navigation map for AGVs. Consequently, the goal of PAN-Robots is to reduce the installation time and costs dramatically by semi-automated plant exploration and localization based on natural landmarks. In this paper, we present our current mapping and localization results based on measurement data acquired at the site of our project partner Coca Cola Iberian Partners in Madrid, Spain.
Low molecular weight chitosan-coated liposomes for ocular drug delivery:In vitroandin vivostudies (2011)

In this study, low molecular weight chitosan coated liposomes (LCHL) were designed and prepared for ocular drug delivery, the coating mechanism was studied, and in vitro and in vivo characterization was conducted. The effects of molecular weight and concentration of low molecular weight chitosan on the liposomal coating were studied. The numeric relations between coating variables and coating efficiency were established using a mathematical model. Morphology of LCHL was examined by transmission electron microscopy (TEM). Cytotoxicity and cell internalization of FITC-BSA labeled LCHL in a rabbit conjunctival epithelium (RCE) cell line were studied. Cyclosporin A (CsA) was encapsulated as a model drug, and in vitro drug release and in vivo drug absorption were investigated. LCHL demonstrated low toxicity to RCE cells. In vitro drug release measurement showed that LCHL had a delayed release profile compared with non-coated liposomes. In vivo study in rabbits showed that the concentrations of CsA in cornea, conjunctiva, and sclera were remarkably increased by LCHL. In conclusion, LCHL might be a potential ocular drug carrier with characteristics such as prolonged drug retention, enhanced drug permeation, and biocompatibility.
Research on the key technology of three dimension rendering pipeline based on mobile devices (2009)

This paper discussed three-dimensional rendering based on mobile device platform. Three-dimensional rendering pipeline is need to optimize for the limitations of the mobile device processing power. the paper researched and analysed the related technologies of how to improve the pipeline, including JIT back-end compiler technology to accelerate the back-end rasterization processing, anisotropic texture mapping filter for mobile devices and hybrid adaptive normal map texture compression algorithm. This provides the basis for the 3D rendering pipeline based on mobile devices.
Integration of environmental factors in process modeling for printed circuit board manufacturing. I. Assembly (2002)

This paper develops a planning methodology for integrating manufacturing related environmental factors into the design and control of production systems, with applications to printed circuit board assembly. Central to this methodology is the definition of manufacturing models for unit-level and batch processes that relate process parameters and component design features to waste streams, energy consumption, yield and process time. Process models for surface mount (stencil application and reflow soldering), through-hole component assembly (wave soldering), and board cleaning are developed. Metrics for workplace environmental hazard and cost are developed to guide design decisions. A case study is presented to illustrate the influencing factors in design and layout for a workstation motherboard.
Megestrol Acetate in Advanced Breast Carcinoma (1994)

Hormonal therapy of breast cancer is the oldest treatment in advanced disease. Durable remissions can be obtained with a wide variety of hormonal manipulations. Oophorectomy was first used to reduce endogenous hormonal levels. Surgical procedures have been supplanted by drugs that reduce hormone secretion or block steroid hormone activity. Tamoxifen is the agent most widely used because of few side effects. Agonists can also be effective. Estrogens, androgens, and progestins have the same level of activity as surgical ablation or drug antagonists (20-40% overall response rate). More than 2,000 patients with advanced breast cancer worldwide have been treated with megestrol acetate in clinical trials. Reports of the trials show a response rate of 27%. In randomized trials, efficacy of megestrol acetate is comparable with tamoxifen and with other hormonal treatments. At the standard dose of 160 mg/day, the major side effect is weight gain. Studies are ongoing to evaluate if high doses of megestrol acetate may increase the response rate with acceptable toxicity.
Preparation of N‐(4‐Methylpentane‐2‐yl)‐N′‐[2‐(2‐phenylpropane‐2‐yl)]‐benzene‐1,4‐diamine (2004)

Abstract Synthesis of N‐(4‐methylpentane‐2‐yl)‐N′‐[2‐(2‐phenylpropane‐2‐yl)]‐benzene1,4‐diamine in four steps starting from methyl 2‐bromobenzoate is described. Chromatographically homogeneous product was prepared in 25% overall yield.
Poly[4-(diacetoxyiodo)styrene] (2002)

(C12H13IO4)n (MW 348.12) (polystyrene-supported derivative of (diacetoxyiodo)benzene used in the oxidation of aniline,1, 2 oxidation of hydroquinones,3-5 oxidative spirocyclization,4 phenolic oxidative coupling,6, 7 oxidation of alcohols,4, 8 oxidative cleavage of diols,1 α-hydroxylation and α-acetoxylation of ketones,3-5 oxidative 1,2-aryl migrations of alkyl aryl ketones,3, 9 generation of carbonyls from hydrazones and oximes,5 oxidation of sulfides3, 5 and thiols,5 iodination of aromatic rings,3, 9 preparation of heterocycles,10, 11 preparation of diaryliodonium salts,12, 13 and the oxidation of triphenylphosphine,5 organotellurium compounds5 and organoselenides14) Alternate Name: PS-I(OAc)2, poly[styrene(iodosoacetate)], polymer-supported (diacetoxyiodo)benzene, PSDIB, polymer-supported phenyliodine diacetate, poly-p-iodosostyryldiacetate. Physical Data: loading ca. 2.0–3.5 mmol g−1.4, 5, 10, 11 Solubility: some solubility in organic solvents such as CH2Cl2 (DCM), EtOAc, and CHCl3; insoluble in Et2O and MeOH. Analysis of Reagent Purity: iodometry and elemental analysis.3-5, 9-11 Preparative Methods: a solution of polystyrene (32 g, 0.31 mol), diiodine (32 g, 0.25 mol), iodine pentoxide (12 g, 0.04 mol), carbon tetrachloride (40 mL) and 50% sulfuric acid (60 mL) in nitrobenzene (400 mL) was kept at 90 °C for 39 h. The reaction mixture was cooled, diluted with chloroform (200 mL) and precipitated with methanol. Filtration gave poly(4-iodostyrene) (65 g) as a pale yellow powder. A mixture of poly(4-iodostyrene) (5 g) and peracetic acid solution [prepared from 30% hydrogen peroxide (25 mL) and acetic anhydride (90 mL)] was kept at 30–40 °C overnight. Precipitation with diethyl ether and filtration gave poly[4-(diacetoxyiodo)styrene] (5.7 g) as a white powder.1, 12 The loading is determined by iodometry or elemental analysis.3-5, 9-11 Handling, Storage, and Precautions: resin is best stored protected from direct sunlight and in a refrigerator, although no appreciable decomposition was observed at room temperature.4, 10
Observation of guided acoustic-wave Brillouin scattering noise and its compensation in digital coherent optical fiber transmission (2018)

We describe the first observation of guided acoustic-wave Brillouin scattering (GAWBS) phase noise in a digital coherent optical fiber transmission. GAWBS noise, which is a forward lightwave generated by thermally excited vibration modes in a cylindrical fiber structure, occurs coherently not only in a signal at a single carrier frequency, but also in modulated wide-band optical signals. Since the signal-to-GAWBS-noise ratio is independent of signal power, it has caused problems in various fields including quantum optics. We point out that GAWBS noise exists even in a digital coherent transmission system such as quadrature amplitude modulation (QAM) and degrades the transmission performance since the phase noise is inevitably included within the bandwidth of the transmitted data. We propose two analogue and one digital method to compensate for the GAWBS noise and demonstrate improved performance in a QAM digital coherent transmission.
Structural Fluctuations of Pyridoxal Kinase: Effect of Viscogen Cosolvents (2000)

The kcatvalues of pyridoxal kinase are attenuated when the viscosity of the solution is varied between 0.89 and 13.75 cp at room temperature. This effect may be due to fluctuations of the tertiary structure of the enzyme in response to changes in the viscosity of the medium. A plot of log kcat against log viscosity according to Kramer equation yields ε = 0.60 and EA = 7.8 kcal/mol. Structural fluctuations of the protein in response to the viscosity of the medium were detected by emission anisotropy measurements. A sharp change in emission anisotropy occurs upon viscosity changes from 2.7 to 0.89 cp. Two rotational correlation times Φ1 = 17 ns and Φ2 = 3.2 ns fit the Perrin plot. The shortest rotational correlation time reflects the rotational mobility of tryptophanyl groups of the protein. It is postulated that enzymatic activity is correlated to a dynamic coupling between the protein matrix and the surrounding medium.
Microstereolithography and characterization of poly(propylene fumarate)-based drug-loaded microneedle arrays (2015)

Drug-loaded microneedle arrays for transdermal delivery of a chemotherapeutic drug were fabricated using multi-material microstereolithography (μSL). These arrays consisted of twenty-five poly(propylene fumarate) (PPF) microneedles, which were precisely orientated on the same polymeric substrate. To control the viscosity and improve the mechanical properties of the PPF, diethyl fumarate (DEF) was mixed with the polymer. Dacarbazine, which is widely used for skin cancer, was uniformly blended into the PPF/DEF solution prior to crosslinking. Each microneedle has a cylindrical base with a height of 700 μm and a conical tip with a height of 300 μm. Compression test results and characterization of the elastic moduli of the PPF/DEF (50:50) and PPF/drug mixtures indicated that the failure force was much larger than the theoretical skin insertion force. The release kinetics showed that dacarbazine can be released at a controlled rate for five weeks. The results demonstrated that the PPF-based drug-loaded microneedles are a potential method to treat skin carcinomas. In addition, μSL is an attractive manufacturing technique for biomedical applications, especially for micron-scale manufacturing.
Dual‐Lobe Reconnection and Horse‐Collar Auroras (2020)

Abstract We propose a mechanism for the formation of the horse‐collar auroral configuration during periods of strongly northward interplanetary magnetic field (IMF), invoking the action of dual‐lobe reconnection (DLR). Auroral observations are provided by the Imager for Magnetopause‐to‐Aurora Global Exploration (IMAGE) satellite and spacecraft of the Defense Meteorological Satellite Program (DMSP). We also use ionospheric flow measurements from DMSP and polar maps of field‐aligned currents (FACs) derived from the Active Magnetosphere and Planetary Electrodynamics Response Experiment (AMPERE). Sunward convection is observed within the dark polar cap, with antisunward flows within the horse‐collar auroral region, together with the NBZ FAC distribution expected to be associated with DLR. We suggest that newly closed flux is transported antisunward and to dawn and dusk within the reverse lobe cell convection pattern associated with DLR, causing the polar cap to acquire a teardrop shape and weak auroras to form at high latitudes. Horse‐collar auroras are a common feature of the quiet magnetosphere, and this model provides a first understanding of their formation, resolving several outstanding questions regarding the nature of DLR and the magnetospheric structure and dynamics during northward IMF. The model can also provide insights into the trapping of solar wind plasma by the magnetosphere and the formation of a low‐latitude boundary layer and cold, dense plasma sheet. We speculate that prolonged DLR could lead to a fully closed magnetosphere, with the formation of horse‐collar auroras being an intermediate step.
Effects of testing age and fostering experience on seizure susceptibility of rats treated prenatally with chlorpromazine (1975)

Offspring of rats treated with 2 mg/kg body weight chlorpromazine (CPZ) on Days 5-8 of gestation had lower seizure thresholds than offspring of saline-treated controls at 30, 60, 90, and 120 days of age. The CPZ-treated offspring were also heavier than controls prior to weaning. Further analysis using cross-fostered litters indicated that at least part of the drug effect on seizure thresholds took place before birth, although a postnatal component was also demonstrated. A striking effect of the fostering experience itself on the seizure threshold prevented conclusions about the relative importance of prenatal and postnatal influences.
Semiautomatic Vendor Independent Software for Assessment of Local Arterial Stiffness (2018)

Background: Stiffened arteries represent a major cardiovascular risk.