gebhart/patrepeval huggingface dataset:
Early Treatment with Anti-VLA-4 mAb Can Prevent the Infiltration and/or Development of Pathogenic CD11b+CD4+ T Cells in the CNS during Progressive EAE (2014)

Natalizumab is a humanized monoclonal antibody against the leukocyte adhesion molecule very late antigen (VLA)-4, and is currently an approved therapy for patients with relapsing-remitting multiple sclerosis (RRMS). However, it is unknown whether natalizumab is beneficial for progressive forms of MS. Therefore, we assessed the effects of anti-VLA-4 monoclonal antibody (mAb) therapy in a progressive experimental autoimmune encephalomyelitis (EAE) mouse model. Notably, we found that early therapy could significantly reduce the severity of progressive EAE, while treatment initiated at an advanced stage was less efficient. Furthermore, we observed the accumulation of a novel subset of GM-CSF-producing CD11b+CD4+ T cells in the CNS throughout disease progression. Importantly, early therapeutic anti-VLA-4 mAb treatment suppressed the accumulation of these GM-CSF-producing CD11b+CD4+ T cells in the CNS along with activated microglia/macrophages populations, and also conferred a protective effect against inflammation-mediated neurodegeneration, including demyelination and axonal loss. Collectively, our data suggest that early treatment with anti-VLA-4 mAb can provide neuroprotection against progressive CNS autoimmune disease by preventing the accumulation of pathogenic GM-CSF-producing CD11b+CD4+ T cells in the CNS.
“α”-Spinasterol (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT"α"-SpinasterolLouis F. Fieser, Mary. Fieser, and Ram Narayan. ChakravartiCite this: J. Am. Chem. Soc. 1949, 71, 6, 2226–2230Publication Date (Print):June 1, 1949Publication History Published online1 May 2002Published inissue 1 June 1949https://pubs.acs.org/doi/10.1021/ja01174a085https://doi.org/10.1021/ja01174a085research-articleACS PublicationsRequest reuse permissionsArticle Views182Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New applications for wide-area monitoring, protection and control (2012)

As operation of electrical transmission systems faces new challenges due to liberalization and integration of renewable energies, novel solutions for power system management are needed. At the same time, the development of smart grids also pushes high performance communication and information technology that contribute decisively in enabling a dynamic monitoring, protection and control of large-scale and wide-spread power systems. The potential offered by smart grids and new fast controllable power systems equipment needs to be exploited by development of valuable applications for power system operation. Moreover, first experiences with selected dedicated applications call for the design of an integrated wide-area monitoring, protection and control (WAMPAC) system. This paper presents recent progress of research unit FOR1511 in the development of WAMPAC applications for stability monitoring, protection schemes based on wide-area information, and real-time congestion management. The research unit aims at developing a coherentWAMPAC system taking into account interdependencies and synergies of newly developed applications and conventional local systems in place.
Protective Effects of Salicornia europaea on UVB-Induced Misoriented Cell Divisions in Skin Epithelium (2020)

Correct orientation of cell division is extremely important in the maintenance, regeneration, and repair of continuously proliferating tissues, such as the epidermis. Regulation of the axis of division of epidermal cells prevents the apoptosis-induced compensatory proliferation, and eventually the cancer. Thus, the orientation of cell division is critical for maintaining the tissue architecture. In this study, we investigated the effects of S. europaea extract on the texture of human skin and the behavior of these cells during skin morphogenesis. In sun-exposed skin, S. europaea improved the texture. A multilayered, highly differentiated in vitro skin model indicated that, S. europaea extract suppressed the UVB-induced changes in the morphology of basal keratinocytes. Orientation of cell division was determined by measuring the axis of mitosis in the vertical sections of our experimental model. Analyses of the digital images revealed that S. europaea preserved the axis of division of basal keratinocytes from UVB-induced perturbations. Our findings uncover a new mechanism by which S. europaea responds to the spindle misorientation induced by UVB.
Unidirectional Vertical Vestibuloocular Reflex Adaptation in Humans Using 1D and 2D Scenes (2022)

This preliminary study is the first to show that physiologically relevant (high frequency) unidirectional increases in vertical VOR gain are possible with just 15 minutes of training. This study sets the basis for future clinical trials examining vertical IVA training in patients, which may provide the first practical rehabilitation treatment to functionally improve the vertical VOR.
Impact of land convection on temperature diurnal variation in the tropical lower stratosphere inferred from COSMIC GPS radio occultations (2013)

Abstract. Following recent studies evidencing the influence of deep convection on the chemical composition and thermal structure of the tropical lower stratosphere, we explore its impact on the temperature diurnal variation in the upper troposphere and lower stratosphere using the high-resolution COSMIC GPS radio-occultation temperature measurements spanning from 2006 through 2011. The temperature in the lowermost stratosphere over land during summer displays a marked diurnal cycle characterized by an afternoon cooling. This diurnal cycle is shown collocated with most intense land convective areas observed by the Tropical Rainfall Measurement Mission (TRMM) precipitation radar and in phase with the maximum overshooting occurrence frequency in late afternoon. Two processes potentially responsible for that are identified: (i) non-migrating tides, whose physical nature is internal gravity waves, and (ii) local cross-tropopause mass transport of adiabatically cooled air by overshooting turrets. Although both processes can contribute, only the lofting of adiabatically cooled air is well captured by models, making it difficult to characterize the contribution of non-migrating tides. The impact of deep convection on the temperature diurnal cycle is found larger in the southern tropics, suggesting more vigorous convection over clean rain forest continents than desert areas and polluted continents in the northern tropics.
Two-Phase Emission Detector for Measuring Coherent Neutrino-Nucleus Scattering (2003)

Coherent scattering is a flavor-blind, high-rate, as yet undetected neutrino interaction predicted by the Standard Model. We propose to use a compact (kg-scale), two-phase (liquid-gas) argon ionization detector to measure coherent neutrino scattering off nuclei. In our approach, neutrino-induced nuclear recoils in the liquid produce a weak ionization signal, which is transported into a gas under the influence of an electric field, amplified via electroluminescence, and detected by phototubes or avalanche diodes. This paper describes the features of the detector, and estimates signal and background rates for a reactor neutrino source. Relatively compact detectors of this type, capable of detecting coherent scattering, offer a new approach to flavor-blind detection of man-made and astronomical neutrinos, and may allow development of compact neutrino detectors capable of nonintrusive real-time monitoring of fissile material in reactors.
Geometric Insight into the Control Allocation Problem for Open-Frame ROVs and Visualisation of Solution (2020)

The overall control system for an open-frame Remotely Operated Vehicle (ROV) is typically built from three subsystems: guidance, navigation and control (GNC). The control allocation plays a vital role in the control subsystem. Typically, open-frame underwater vehicles have p actuators (thrusters) for the motion in the horizontal plane, and the control allocation problem, in this case, is very complex and hard to visualise, because the normalised constrained control subset is a p-dimensional unit cube. The aim of this paper is to give a clear picture and a geometric interpretation of the problem and to introduce a hybrid method, based on the integration of a weighted pseudoinverse and the fixed-point method. The main idea of the hybrid method is visualised, and the deep geometric insight is provided using a “virtual” ROV in low-dimensional control spaces, including visualisation of the attainable command set, solution lines, control energy spheres and the role of pseudoinverse and fixed-point iterations. The same concepts are then extended to higher-dimensional cases, for open-frame ROV with four X-shaped (vectored) horizontal thrusters, which is one of the most common thruster configurations for commercial ROVs. The proposed hybrid method has been developed, integrated into a generic fault-tolerant ROV control system and evaluated in virtual and real-world environments off the west coast of Ireland using observation-class ROV Latis and work-class ROV Étaín.
Inclination measurement of human movement using a 3-D accelerometer with autocalibration (2004)

In the medical field, accelerometers are often used for measuring inclination of body segments and activity of daily living (ADL) because they are small and require little power. A drawback of using accelerometers is the poor quality of inclination estimate for movements with large accelerations. This paper describes the design and performance of a Kalman filter to estimate inclination from the signals of a triaxial accelerometer. This design is based on assumptions concerning the frequency content of the acceleration of the movement that is measured, the knowledge that the magnitude of the gravity is 1 g and taking into account a fluctuating sensor offset. It is shown that for measuring trunk and pelvis inclination during the functional three-dimensional activity of stacking crates, the inclination error that is made is approximately 20 root-mean square. This is nearly twice as accurate as compared to current methods based on low-pass filtering of accelerometer signals.
High Efficiency Vehicular Gas Turbines (2005)

&lt;div class="htmlview paragraph"&gt;Recuperated intercooled gas turbine cycles offer efficiencies in the 40% and higher range at medium to high loads. Although these cycles offer better low-load efficiency than other gas turbine cycles, the idle and low-load fuel consumption are still not good enough for satisfactory vehicle operation. In addition, response time to sudden demands for power is slow. The multi-pressure gas turbine allows the combustion air to enter the cycle at a different point, reducing the mass flow and the rating of the gas turbine for efficient operation at low power. Yet, the full power of the gas turbine is available quickly for acceleration or hill climbing.&lt;/div&gt;
How good is random linear coding based distributed networked storage (2005)

Abstract — We consider the problem of storing a large file or multiple large files in a distributed manner over a network. In the framework we consider, there are multiple storage locations, each of which only have very limited storage space for each file. Each storage location chooses a part (or a coded version of the parts) of the file without the knowledge of what is stored in the other locations. We want a file-downloader to connect to as few storage locations as possible and retrieve the entire file. We compare the performance of three strategies: uncoded storage, traditional erasure coding based storage, random linear coding based storage motivated by network coding. We demonstrate that, in principle, a traditional erasure coding based storage (eg: Reed-Solomon Codes) strategy can almost do as well as one can ask for with appropriate choice of parameters. However, the cost is a large amount of additional storage space required at the centralized server before distribution among multiple locations. The random linear coding based strategy performs as well without suffering from any such disadvantage. Further, with a probability close to one, the minimum number of storage location a downloader needs to connect to (for reconstructing the entire file), can be very close to the case where there is complete coordination between the storage locations and the downloader. We also argue that an uncoded strategy performs poorly. I.
Biochemical and pharmacological effects of the direct thrombin inhibitor AR-H067637 (2009)

AZD0837 is in development as a new oral anticoagulant for use in thromboembolic disorders. In vivo, AZD0837 is converted to AR-H067637, a selective and reversible direct thrombin inhibitor. Established biochemical methods were used to assess and measure the biochemical and pharmacological properties of AR-H067637. Both direct Biacore binding studies of AR-H067637 with immobilised alpha-thrombin and inhibition studies using pre-steady state kinetics with thrombin in the fluid phase confirmed that AR-H067637 is a rapid-binding, reversible and potent (inhibition constant K(i) = 2-4 nM), competitive inhibitor of thrombin, as well as of thrombin bound to fibrin (clot-bound thrombin) or to thrombomodulin. The total amount of free thrombin generated in platelet-poor clotting plasma was inhibited concentration-dependently by AR-H067637, with a concentration giving half maximal inhibition (IC(50)) of 0.6 microM. Moreover, AR-H067637 is, with the exception of trypsin, a selective inhibitor for thrombin without inhibiting other serine proteases involved in haemostasis. Furthermore, no anticoagulant effect of the prodrug was found. AR-H067637 prolonged the clotting time concentration-dependently in a range of plasma coagulation assays including activated partial thromboplastin time, prothrombin time, prothrombinase-induced clotting time, thrombin time and ecarin clotting time. The two latter assays were found to be most sensitive for assessing the anticoagulant effect of AR-H067637 (plasma IC(50) 93 and 220 nM, respectively). AR-H067637 also inhibited thrombin-induced platelet activation (by glycoprotein IIb/IIIa exposure, IC(50) 8.4 nM) and aggregation (IC(50) 0.9 nM). In conclusion, AR-H067637 is a selective, reversible, competitive inhibitor of alpha-thrombin, with a predictable anticoagulant effect demonstrated in plasma coagulation assays.
Carcinogenicity of estrogens in human breast epithelial cells1 (2001)

Epidemiological and clinical evidences indicate that breast cancer risk is associated with prolonged ovarian function that results in elevated circulating levels of steroid hormones. Principal among these is estrogen, which is associated with two important risk factors, early onset of menarche and late menopause. However, up to now there is no direct experimental evidence that estrogens are responsible of the initiation of human breast cancer. We postulate that if estrogens are causative agents of this disease, they should elicit in human breast epithelial cells (HBEC) genomic alterations similar to those exhibited by human breast cancers, such as DNA amplification and loss of genetic material representing tumor suppressor genes. These effects could result from binding of the hormone to its nuclear receptors (ER) or from its metabolic activation to reactive metabolites. This hypothesis was tested by treating with the natural estrogen 17β‐estradiol (E 2 ) and the synthetic steroid diethylstilbestrol (DES) MCF‐10F cells, a HBEC line that is negative for ER. Cells treated with the chemical carcinogen benzo (a) pyrene (BP) served as a positive control of cell transformation. BP‐, E 2 ‐, and DES‐treated MCF‐10F cells showed increases in survival efficiency and colony efficiency in agar methocel, and loss of ductulogenic capacity in collagen gel. The largest colonies were formed by BP‐treated cells, becoming progressively smaller in DES‐ and E 2 ‐treated cells. The loss of ductulogenic capacity was maximal in BP‐, and less prominent in E2‐ and DES‐treated cells. Genomic analysis revealed that E 2 ‐ and DES‐treated cells exhibited loss of heterozygosity in chromosomes 3 and 11, at 3p21, 3p21‐21.2, 3p21.1–14.2, and 3p14.2–14.1, and at 11q23.3 and 11q23.1–25 regions, respectively. It is noteworthy that these loci are also affected in breast lesions, such as ductal hyperplasia, carcinoma in situ, and invasive carcinoma. Our data are the first ones to demonstrate that estrogens induce in HBEC phenotypic changes indicative of cell transformation and that those changes are associated with significant genomic alterations that might unravel new pathways in the initiation of breast cancer.
Fabrication of superhydrophobic composite coating based on fluorosilicone resin and silica nanoparticles (2018)

Composite superhydrophobic coating built with film former and filler is attracting much attention for its facile and convenient fabrication, but significant limitations and disadvantages still remain. In this paper, a composite superhydrophobic coating is introduced which can be cured at room temperature and made by dispersing modified silica nanoparticles with 1H, 1H, 2H, 2H-perfluorooctyltriethoxysilane in fluorosilicone resin. Silica content and dispersion time showed obvious influences on the morphology and topography of composite coating by reuniting dispersed nanoparticles to form peaks on the surface. Excessively large distances between these peaks would decrease water contact angle value. Increasing slope of peaks, appropriate distance between peaks and decreasing diameter size of peaks would diminish sliding angle value. Formation mechanism of the composite coating based on fluorosilicone resin and modified nanoparticles was explained using interpenetrating polymer model.
The synthesis of a proteinase inhibitor, alpha-1-antichymotrypsin, by human breast epithelial cells (1981)

The synthesis and release of glycoproteins were studied in organ cultures of human breast surgical specimens and in established breast epithelial cell lines, MCF-7 and MDA-MB-231. Biosynthesis was monitored by the incorporation of 14C-glucosamine. Labeled macromolecules in the culture supernatants were analyzed by biochemical and immunological techniques. One to 8% of the labeled glycoproteins from benign breast and infiltrating ductal carcinoma specimens was precipitated by antibodies produced against human serum alpha-1-antichymotrypsin. Twelve percent of the total glycoproteins from the culture supernatants of the MCF-7 cell line was identified as alpha-1-antichymotrypsin. Both the normal serum and the human breast epithelia-derived proteinase inhibitor can be resolved into similar subclasses by two-dimensional gel electrophoresis. MDA-MD-231 and MCF-7 cells which were extensively washed with EDTA, serum-free medium, and phosphate-buffered saline retain this proteinase inhibitor on their cell surfaces. Three to 4% of the total cell-surface iodinated components was immunoprecipitated by these specific antibodies. Since alpha-1-antichymotrypsin is a potent inhibitor of neutral proteinases such as cathepsin G, the demonstration of its synthesis by benign and malignant breast epithelial cells is of considerable interest. This glycoprotein may represent the epithelia's own protective shield of cell surface components and the cell's attempt to moderate the effects of invading leukocytes. In addition, it may play a regulatory role in the maintenance of three-dimensional glandular structures.
Active matrix with integrated drivers on soda‐lime glass using poly‐CdSe and poly‐Ge (1993)

Abstract— For the first time, a poly‐CdSe active matrix with poly‐CdSe/poly‐Ge integrated driver circuits was realized. Despite compromises in device performance, induced by combining the existing driver and matrix technologies, excellent circuit results were obtained, with inverter delays down to 30 ns in a 25‐μm technology.
Use of Pd–Fe and Ni–Fe–Nb as Soft Magnetic Layers in Ferromagnetic Josephson Junctions for Nonvolatile Cryogenic Memory (2014)

Josephson junctions containing ferromagnetic layers are under consideration as the basic elements for cryogenic random access memory. For memory applications, either the amplitude of the critical current or the phase shift across the junction must be controllable by changing the direction of magnetization of one or more of the ferromagnetic layers in the junction. We have measured the critical currents in large-area Josephson junctions containing three ferromagnetic layers. These junctions carry spin-triplet supercurrent. This work addresses the choice of material and optimum thickness for the one soft magnetic layer in such junctions. We have used either a Pd-Fe or Ni-Fe-Nb alloy for the soft layer, and find hysteresis in the low-field “Fraunhofer patterns” due to magnetic switching of the soft layer. The critical current is one order of magnitude smaller in the junctions containing the Ni-Fe-Nb alloy compared to those containing Pd-Fe alloy, which is probably due to strong spin-memory loss in the former. While the large-area junctions studied here are not suitable for memory applications, these experiments lay the groundwork for future studies of submicron junctions where the magnetic state of the junction can be controlled by shape anisotropy.
Fingerprint feature enhancement using block-direction on reconstructed images (2002)

Fingerprints have been used as unique identifiers of individuals for a very long time. The identification of fingerprint (FP) images is based on matching the features of a query FP, against those stored in a database. As FP databases are characterized by their large size and may contain noisy and distorted query images, an efficient and robust representation of FP images is essential for a reliable identification. Assuming the FPs to be sample images from non-stationary processes of textured images of flow patterns, we propose a new technique for preprocessing FP images for the purpose of identification. In the proposed algorithm, the enhancement as well as the ridge extraction processes are based on local dominant ridge directions. The obtained thinned image is then smoothed using morphological operations to detect the FP structural features. The proposed algorithm results in an efficient, robust and fast representation of FPs which accurately retains the fidelity in minutiae (ridge endings and bifurcations).