gebhart/patrepeval huggingface dataset:
Second-look laparotomy in epithelial ovarian carcinoma. Prognostic factors associated with survival duration (1988)

This article that reports on 70 consecutive patients is one of only a few studies of advanced ovarian cancer that have attempted to define predictive factors associated with survival duration after second-look laparotomy. As in many other investigations, several factors have been analyzed for predicting second-look outcome. The prognostic variables analyzed in this study included age, stage, histologic grade, residual disease status after initial surgery, and type (cisplatin versus no cisplatin) and number of cycles of chemotherapy. Only stage (P = 0.002) and optimal disease (less than 2 cm residual tumor size) after initial surgery (P less than 0.001) were significantly associated with the absence of disease at second-look laparotomy, and both were significant predictors of second-look outcome in a multivariate logistic regression model. Their impact on actuarial survival after second-look laparotomy diminished, however. Actuarial survival after second-look laparotomy was associated with residual tumor size at second-look surgery (P = 0.02). According to second-look findings, the 3-year actuarial survival rates and standard errors were as follows: no pathologic evidence of disease, 80.7% +/- 13.4% 3-year survival; microscopic disease plus less than or equal to 2 cm residual disease, 49.1% +/- 13.1% survival; and gross residual disease (i.e., greater than 2 cm maximum tumor diameter), 29.5% +/- 11.4% survival. We also examined the effect of extensive tumor resection at second-look laparotomy on survival for patients with greater than 2 cm gross residual disease. Optimum resection (less than 2 cm residual tumor mass) resulted in significantly greater survival than suboptimum resection (P less than 0.001). This strongly suggests that there is a survival advantage associated with optimum resection at second-look laparotomy.
Expansion of SARS-CoV-2–Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients (2020)

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in late 2019 and has since become a global pandemic. Pathogen-specific Abs are typically a major predictor of protective immunity, yet human B cell and Ab responses during COVID-19 are not fully understood. In this study, we analyzed Ab-secreting cell and Ab responses in 20 hospitalized COVID-19 patients. The patients exhibited typical symptoms of COVID-19 and presented with reduced lymphocyte numbers and increased T cell and B cell activation. Importantly, we detected an expansion of SARS-CoV-2 nucleocapsid protein-specific Ab-secreting cells in all 20 COVID-19 patients using a multicolor FluoroSpot Assay. Out of the 20 patients, 16 had developed SARS-CoV-2-neutralizing Abs by the time of inclusion in the study. SARS-CoV-2-specific IgA, IgG, and IgM Ab levels positively correlated with SARS-CoV-2-neutralizing Ab titers, suggesting that SARS-CoV-2-specific Ab levels may reflect the titers of neutralizing Abs in COVID-19 patients during the acute phase of infection. Last, we showed that IL-6 and C-reactive protein serum concentrations were higher in patients who were hospitalized for longer, supporting the recent observations that IL-6 and C-reactive protein could be used as markers for COVID-19 severity. Altogether, this study constitutes a detailed description of clinical and immunological parameters in 20 COVID-19 patients, with a focus on B cell and Ab responses, and describes tools to study immune responses to SARS-CoV-2 infection and vaccination.
Locomotive analysis of a single-input three-link snake robot (2016)

When commanding gaits for snake robots and other articulated systems, direct control of all possible joint inputs may not always be necessary or optimal to achieve a locomotive goal. Here we consider a three-link nonholonomic snake robot-an already underactuated system with locomotive capabilities in SE(2)-and reduce its input space to a single actuated joint, replacing the other joint's motor with a passive mass-spring-damper system. We show that the modified system can operate dynamically in addition to kinematically, and that it is possible to find gaits that produces locomotion similar to a fully actuated system. In particular, we describe the emergence of a new type of gait that incorporates the system's singular configurations to produce high locomotive efficiency without incurring unbounded constraint forces.
Power-dependence of high-Q optomechanical oscillators: from pre-oscillation, to oscillation slope, to Drude-plasma (2017)

We demonstrate the power dependence of high-Q OMOs, which permits pre-oscillation, oscillation, and chaos like performance. Power dependence on mechanical frequency is also modeled and simulations are compared to the measured data.
Tumor Suppressor Immune Gene Therapy to Reverse Immunotherapy Resistance (2021)

Abstract Background While immune checkpoint inhibitors are becoming a standard of care for multiple types of cancer, the majority of patients do not respond to this form of immunotherapy. New approaches are required overcome resistance to immunotherapies. Methods We investigated the effects of adenoviral p53 (Ad-p53) gene therapy in combination with immune checkpoint inhibitors and selective IL2 or IL15 CD122/132 agonists in the aggressive B16F10 tumor model resistant to immunotherapies. To assess potential mechanisms action, pre and post Ad-p53 treatment biopsies were evaluated for changes in gene expression profiles by Nanostring IO 360 assays. Results Substantial synergy of “triplet” Ad-p53 + CD122/132 + anti-PD-1 therapy resulted in potential curative effects associated with complete tumor remissions of both primary and contralateral tumors. Interestingly, contralateral tumors which were not injected with Ad-p53 showed robust abscopal effects resulting in statistically significant decreases in tumor size and increased survival (p&lt;0.001). None of the monotherapies or doublet treatments induced complete tumor regressions. Ad-p53 treatment increased Type I Interferon, CD8 + T cell, immuno-proteosome antigen presentation and tumor inflammation gene signatures. Ad-p53 treatment also decreased immune suppressive TGF-beta, beta-catenin, macrophage, and endothelium gene signatures, which may contribute to enhanced immune checkpoint inhibitor (CPI) efficacy. Unexpectedly, a number of previously unidentified, strongly p53 down regulated genes associated with stromal pathways and IL10 expression identified novel anti-cancer therapeutic applications. Conclusions These results imply the ability of Ad-p53 to induce efficacious local and systemic anti-tumor immune responses with the potential to reverse resistance to immune checkpoint inhibitor therapy when combined with CD122/132 agonists and immune checkpoint blockade. Our findings further imply that Ad-p53 has multiple complimentary immune mechanisms of action which support future clinical evaluation of triplet Ad-p53, CD122/132 agonist and immune checkpoint inhibitor combination treatment.
Visualizing the structure of the World Wide Web in 3D hyperbolic space (1995)

We visualize the structure of sections of the World Wide Web by constructing graphical representations in 3D hyperbolic space. The felicitous property that hyperbolic space has "more room" than Euclidean space allows more information to be seen amid less clutter, and motion by hyperbolic isometrics provides for mathematically elegant navigation. The 3D graphical representations, available in the We-bOOGL or VRML file formats, contain link anchors which point to the original pages on the Web itself. We use the Geomview /WebOOGL 3D Web browser as an interface between the 3D representation and the actual documents on the Web. The Web is just one example of a hierarchical tree structure with links "back up the tree" i.e. a directed graph which contains cycles. Our information visualization techniques are appropriate for other types of directed graphs with cycles, such as filesystems with symbolic links.
Análisis de la mortalidad en pacientes con fracturas subcapitales de cadera (1993)

Resumen.—El objetivo del presente trabajo es realizar un estudio analitico restrospectivo de la mortalidad de una serie de 528 fracturas subcapitales de cadera en 523 pacientes trata­ dos en nuestro centro mediante protesis cervico-cefalica cementada durante el periodo de 1978-1986. De estos 523 pacientes, 190 (36%) habian fallecido en el momento de realizar el estudio. Hemos analizado la mortalidad hospitalaria, 47 casos (9%) y 6 meses despues de la intervencion, 104 (20%). Se han demostrado como factores de alto riesgo: edad superior a 85 anos, presentar tres o mas enfermedades asociadas, complicaciones generales en el pos­ toperatorio (escaras, tromboembolismo pulmonar, infarto agudo de miocardio, neumonia, etc.) complicaciones locales como la luxacion de la protesis y finalmente, una demora en la inter­ vencion superior a 6 dias. MORTALITY ANALYSIS IN PATIENTS WITH SUBCAPITAL HIP FRACTURES. Summary.—We report a retrospective study analyzing the mortality of 528 femoral neck fractures in 523 patients treated with Thompson or Cathcart prosthesis during the period 1978-1986. The hospital mortality was 9% (47 cases) and 20% (104 cases) the mortality and six-months after surgery. High risk factors, were found to be: age more than 85 years-old, three o more preoperative illness, postoperative general complications (Pulmonar tromboembolism, Acute myocardial infarction, sores, pneumonia), dislocation of the prosthesis and a more than 6 days delay surgery.
ChemInform Abstract: Chemistry of 5‐Oxodihydroisoxazoles. Part 18. Synthesis of Oxazoles by the Photolysis and Pyrolysis of 2‐Acyl‐5‐oxo‐2,5‐dihydroisoxazoles. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Gatica: Linked Sensed Data Enrichment and Analytics Middleware for IoT Gateways (2015)

Raw sensed data lacks semantics. This poses a challenge to apply analytics directly to raw IoT sensor data. Such operational data requires an intensive enrichment processes to drive value. Pragmatic use of naming conventions and taxonomies can increase the quality of data and make it more interpretable. In this paper, we incorporate semantic and linked data technologies and offer a middleware called Gatica, to dynamically inject semantics to make the raw streaming data of an IoT gateway "Rich" on the device layer. Gatica collects the real-time sensor data, enriches them using annotations then transforms and exposes them in RDF triples, and finally streams RDF objects to the analytic endpoint for querying the linked sensor streaming data. Various analytic applications can utilize our middleware by sending SPARQL requests over the sensor network to our query interface and retrieving the results. Our middleware offers the ability to discover hidden patterns of mutually correlated variables and uncover actionable information within raw data for more utility. This paper details Gatica's architecture together with its implementation.
Septic Cortical Thrombophlebitis (1990)

Thrombosis of cortical veins has been postulated as an important cause of seizures and focal neurologic deficits in patients with bacterial meningitis. Diagnoses from autopsies, angiograms, and medical records at Massachusetts General Hospital, 1960-1984, were reviewed to identify patients with septic cortical thrombophlebitis. Only 10 confirmed cases of septic cortical vein thrombosis without sagittal sinus thrombosis were found. Meningitis was present in nine patients; Streptococcus pneumoniae was isolated from the blood or cerebrospinal fluid of five patients. Common clinical manifestations included fever, seizures, and focal neurologic signs. Half the patients survived, but three had persistent disabilities. Cortical vein thrombosis could be documented in only approximately 1% of 790 cases of bacterial meningitis. In 97 patients with meningitis who died and had autopsies, cortical thrombophlebitis was identified in 5%. In autopsied patients, other pathologic processes including arteritis, ventriculitis, cavernous sinus thrombosis, and cerebral infarctions were usually more prominent than venous thrombosis. Cortical thrombophlebitis does not appear to be the major cause of seizures or focal neurologic signs during bacterial meningitis.
Impact of the rs1024611 Polymorphism of CCL2 on the Pathophysiology and Outcome of Primary Myelofibrosis (2021)

Single nucleotide polymorphisms (SNPs) can modify the individual pro-inflammatory background and may therefore have relevant implications in the MPN setting, typified by aberrant cytokine production. In a cohort of 773 primary myelofibrosis (PMF), we determined the contribution of the rs1024611 SNP of CCL2-one of the most potent immunomodulatory chemokines-to the clinical and biological characteristics of the disease, demonstrating that male subjects carrying the homozygous genotype G/G had an increased risk of PMF and that, among PMF patients, the G/G genotype is an independent prognostic factor for reduced overall survival. Functional characterization of the SNP and the CCL2-CCR2 axis in PMF showed that i) homozygous PMF cells are the highest chemokine producers as compared to the other genotypes; ii) PMF CD34+ cells are a selective target of CCL2, since they uniquely express CCR2 (CCL2 receptor); iii) activation of the CCL2-CCR2 axis boosts pro-survival signals induced by driver mutations via Akt phosphorylation; iv) ruxolitinib effectively counteracts CCL2 production and down-regulates CCR2 expression in PMF cells. In conclusion, the identification of the role of the CCL2/CCR2 chemokine system in PMF adds a novel element to the pathophysiological picture of the disease, with clinical and therapeutic implications.
Laboratory Wheel Tracking Apparatus for Bituminous Pavement Studies (1992)

Abstract Rutting deformation is one of the most common forms of pavement distress found on bituminous pavements, especially in the hot, tropical climate of Singapore. These deformations are usually found in the wheel track on roads carrying heavy, slow moving, channeled traffic, such as in the city and industrial areas at traffic light junctions. To and our investigation into the nature of pavement rutting, a laboratory wheel-tracking apparatus was used to simulate channeled wheel traffic loading under controlled conditions. It was upgraded with automated temperature and rut profile measurement capability. This article describes the features of the apparatus, which include temperature control of test specimens from ambient (27°C) to 70°C via a water bath with an adjustable weir, speed control of 0 to 80 wheel passes per minute, and variable wheel loading from 18 to 54 kg giving approximate equivalent tire pressures of 175 to 530 kPa. The apparatus can be used to simultaneously test three standard specimens of dimensions 405 mm by 135 mm by 90 mm-thickness. Single tests of two other sizes, which are two or three times the width of the standard specimen, are permissible. The rut depths are monitored by means of three linear variable displacement transducers (LVDTs), which measure the vertical displacements of each of the three wheel axles independently as rutting progresses. Due to errors induced by machine vibrations, accurate rut profile measurements can be made only under static conditions at selected intervals of wheel passes. With the use of a 200-ton-capacity static press, uniform dense asphaltic concrete beam specimens can be made, giving reasonably repeatable rutting test data on the apparatus, thus making it a valuable tool for evaluating the ratting potential of various mixes.
High-efficiency organic polymer light-emitting heterostructure devices on flexible plastic substrates (2000)

In this letter, we describe a high-efficiency organic polymer light-emitting heterostructure device with aluminum cathode fabricated on a thin, flexible plastic substrate. The device consists of a hole transporting (amine-fluorene) and an emissive (benzothiadiazole-fluorene) conjugated organic polymer layers. The best heterostructure device has a green light emission and a maximum luminance higher than 2000 cd/m2. Device shows a maximum emission of ∼56.2 cd/A and, accordingly, a maximum luminous and external quantum efficiency of ∼9.0 lm/W and ∼15%, respectively. This organic light-emitting diode performance is acceptable for flat panel display applications.
Determination of Microgel Structure by Small‐Angle Neutron Scattering (2011)

This chapter contains sections titled: Introduction Form Factor of Microgels Core–Shell Particles Summary References
Highly Efficient Wettability Control via Three-Dimensional (3D) Suspension of Titania Nanoparticles in Polystyrene Nanofibers (2013)

Electrospinning is a simple and highly versatile method for the large-scale fabrication of polymeric nanofibers. Additives or fillers can also be used to functionalize the nanofibers for use in specific applications. Herein, we demonstrate a novel and efficient way to fabricate superhydrophobic to hydrophilic tunable mats with the combined use of electrospinning and electrospraying that may be suitable for mass production on the merits of rapid deposition. The tunable nanocomposite mats were comprised of hydrophobic polystyrene nanofibers and hydrophilic titania nanoparticles. When the electrical conductivity of the electrospinning solution was increased, the surface morphology of the mats changed noticeably from a bead-on-string structure to an almost bead-free structure. Polystyrene (PS)-titania nanocomposite mats initially yielded a static water contact angle as high as 140° ± 3°. Subsequently exposing these mats with relatively weak ultraviolet irradiation (λ = 365 nm, I = 0.6 mW/cm²) for 2 h, the unique 3D suspension of the photoactive titania nanoparticles maximized the hydrophilic performance of the mats, reducing the static water contact angle to as low as 26° ± 2°. The tunable mats were characterized by scanning electron microscopy (SEM), static water contact angle (WCA) measurements, and energy-dispersive X-ray spectroscopy (EDX). Our findings confirmed that the tunable mats fabricated by the simultaneous implementation of electrospraying and electrospinning had the most efficient ultraviolet (UV)-driven wettability control in terms of cost-effectiveness. Well-controlled tunable hydrophobic and hydrophilic mats find potential applications in functional textiles, environmental membranes, biological sensors, scaffolds, and transport media.
Evolutionary design optimization of a microoptical collimation system (1998)

The production of specimen for microsystems or microcomponents is both, time and material-consuming. In a traditional design process the number of possible variations which can be considered is very limited. Thus, in microsystem technology computer-based design techniques become more and more important- similar to the development of microelectronics. The computer aided development and optimization is based on simulation models. This paper presents the concept of a partially automated design optimization as an application of our evolutionary optimization environment. A 2-lens-system being part of a heterodyne receiver, a microoptical communication module, has to be optimized to be as insensitive to fabrication tolerances as possible while still maintaining optimal properties of the collimation system. The optimization results obtained are compared to a hillclimbing strategy with respect to both, convergence reliability and convergence velocity.
Crystallization of the coiled-coil domain of Atg16 essential for autophagy (2008)

Atg16 is a scaffold protein that interacts with Atg12-Atg5 protein conjugates via its N-terminal domain and self-assembles via its coiled-coil domain, thus forming a multimeric Atg12-Atg5-Atg16 complex that is essential for autophagy. The coiled-coil domain of Atg16 was expressed, purified and crystallized. The crystal belonged to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = 127.7, c = 77.8 A. Self-rotation functions and volume-to-weight ratio values suggested that the crystal may contain six molecules per asymmetric unit. Since the domain does not contain a methionine residue, selenomethionine-labelled crystals were prepared with a leucine-to-methionine substitution in the coiled-coil domain and these crystals were used for the collection of single-wavelength anomalous dispersion data to 2.5 A resolution.
Performance Mechanism of Active Clamp Resonant SEPIC Converter in Renewable Energy Systems (2019)

A 48V active clamp resonant single-ended primary inductor (SEPIC) converter has advantages, which are switch voltage stress suppression and achieving zero-voltage switching (ZVS). Therefore, it is effective in renewable energy systems that can provide a 48V dc bus. This paper clarifies how the active clamp resonant SEPIC converter is affected by whether the active clamp circuit is connected to the input or output side and its performance mechanism is clarified.
Effectiveness of community-based multidisciplinary integrated care for older people: a protocol for a systematic review (2022)

CRD42022309744.
<title>Advanced adaptive optics technology development</title> (2002)

The NSF Center for Adaptive Optics (CfAO) is supporting research on advanced adaptive optics technologies. CfAO research activities include development and characterization of micro-electro-mechanical systems (MEMS) deformable mirror (DM) technology, as well as development and characterization of high-resolution adaptive optics systems using liquid crystal (LC) spatial light modulator (SLM) technology. This paper presents an overview of the CfAO advanced adaptive optics technology development activities including current status and future plans.
Carbamate Prodrug Concept for Hydroxamate HDAC Inhibitors (2011)

Virtual screening efforts have identified several novel HDAC6 inhibitors with cellular isoform selectivity. In particular, a carbamate-protected hydroxamic acid exhibited improved effects with respect to protein hyperacetylation compared with the parent hydroxamate, possibly because of improved cell permeability. The carbamate structure therefore represents a potential prodrug concept for hydroxamic acid-containing HDAC inhibitors.
ChemInform Abstract: MECHANISM OF BASE PROMOTED REDUCTION OF NICKEL(III) COMPLEXES OF MACROCYCLIC AMINES, A COORDINATED LIGAND RADICAL INTERMEDIATE (1975)

Abstract Die Mechanismen der Zersetzung der beiden Ni(III)‐Komplexe (I), erhalten bei der Oxidation entsprechender Ni(II)‐Derivate mit NOClO 4 in Acetonitril, werden untersucht.
An End-to-End Neural Network for Image-to-Audio Transformation (2023)

This paper describes an end-to-end (E2E) neural architecture for the audio rendering of small portions of display content on low resource personal computing devices. It is intended to address the problem of accessibility for vision-impaired or vision-distracted users at the hardware level. Neural image-to-text (ITT) and text-to-speech (TTS) approaches are reviewed and a new technique is introduced to efficiently integrate them in a way that is both efficient and back-propagate-able, leading to a non-autoregressive E2E image-to-speech (ITS) neural network that is efficient and trainable. Experimental results are presented showing that, compared with the non-E2E approach, the proposed E2E system is 29% faster and uses 19% fewer parameters with a 2% reduction in phone accuracy. A future direction to address accuracy is presented.