gebhart/patrepeval huggingface dataset:
External Influences on Invertebrate Brain Histamine and Related Compounds via an Automated Derivatization Method for Capillary Electrophoresis (2017)

Histamine has been shown to modulate visual system and photic behavior in arthropods. However, few methods are available for the direct quantification of histamine and its precursor and metabolites in arthropod brain. In this work, a method for the separation of histamine, its precursor histidine, and its metabolite N-methyl-histamine from brain extracts of a freshwater crustacean has been developed using capillary electrophoresis with laser-induced fluorescence detection. Molecules were tagged on their primary amine function with naphthalene-2,3-dicarboxaldehyde, but derivatized histamine and N-methyl-histamine exhibited poor stability in contrast to derivatized histidine. To overcome this limitation, an automated derivatization performed within the capillary electrophoresis instrument was optimized and quantitatively validated. The limits of detection were 50, 30, and 60 nmol/L for histidine, histamine, and N-methyl-histamine, respectively. This study reports, for the first time, the amounts of histamine and its related compounds in brain extracts from populations of the freshwater amphipod Gammarus fossarum, and shows that these amounts vary mainly according to population and season, but are not affected by an experimental electrical shock.
Ligands that activate protein kinase-C differ in their ability to regulate basic fibroblast growth factor and insulin-like growth factor- I messenger ribonucleic acid levels (1993)

In this study, rat dermal fibroblasts were used as a model system to examine the ability of ligands that are known to activate protein kinase-C to regulate the levels of the mRNAs encoding basic fibroblast growth factor (bFGF) and insulin-like growth factor-I (IGF-I), two growth factors that are thought to be important in processes such as tissue repair and regeneration and wound healing. Treatment of fibroblasts with the phorbol ester phorbol 12-myristate 13-acetate (PMA), thrombin, bradykinin, serotonin, angiotensin-II, or bombesin increased protein kinase-C activity to a similar degree. Treatment of fibroblasts with 1 microM serotonin transiently increased bFGF mRNA levels about 3-fold compared to the level in control cells maintained in serum-free medium with 0.25% BSA and decreased IGF-I mRNA levels by approximately 50% compared to the level in control cells. This is similar to the previously described changes induced by bradykinin in these cells, but different from the more marked and sustained changes induced by thrombin and PMA. In contrast, angiotensin-II and bombesin had no effect on bFGF or IGF-I mRNA levels. The effects of serotonin, bradykinin, and PMA on bFGF and IGF-I mRNA levels were abrogated by preincubation of cells in 250 nM PMA to down-regulate protein kinase-C. In contrast, the effect of thrombin on bFGF mRNA levels was only partially inhibited by down-regulation of protein kinase-C, while its effect on IGF-I mRNA levels was unaffected. The activation of signaling pathways by the different ligands was further investigated to begin to determine the mechanism for the differences in the effects of thrombin vs. serotonin and bradykinin and in the effects of these three ligands vs. angiotensin-II and bombesin. All of the ligands activated phospholipase-D to a similar degree, suggesting that activation of this enzyme was not responsible for the differential effects of the ligands. In contrast, thrombin, serotonin, and bradykinin had marked effects on the hydrolysis of phosphatidylcholine and phosphatidylinositol, whereas bombesin and angiotensin-II had a small effect on phosphatidylcholine hydrolysis and no effect on phosphatidylinositol hydrolysis.
Prognostic Impact of 6 Min Walk Test Distance in Patients with Systolic Heart Failure: Insights from the WARCEF Trial (2020)

In HFrEF, 6MWTD is independently associated with all-cause death, CV death, and HFH. 6MWTD of 200 m is the best cut-off point for predicting these adverse events. The prognostic impact of 6MWTD for HFH was only observed in older patients.
Safety of Physiological Testosterone Therapy in Women: Lessons from Female-to-Male Transsexuals (FMT) Treated with Pharmacological Testosterone Therapy (2010)

No significant serious adverse effects were reported in FMTs treated with pharmacological doses of T. In light of the findings with supraphysiological doses of T, we suggest that treatment with T at doses producing physiological levels in women with sexual dysfunction are expected to produce limited and minimal adverse effects.
National Comprehensive Cancer Network guidelines for small intestine cancers reflect new findings (2020)

T he National Comprehensive Cancer Network (NCCN) issued the first set of guidelines in United States the treatment of small bowel adenocarcinoma (SBA), a rare cancer type that is increasing in incidence.
Validity and Reliability of the Revised Convergence Insufficiency Symptom Survey in Children Aged 9 to 18 Years (2003)

Children with CI showed a significantly higher CISS symptom score than children with normal binocular vision. The results of the study indicate that the CISS is a valid and reliable instrument to use as an outcome measure for children aged 9 to 18 who are enrolled in clinical research concerning CI.
Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes (2019)

Plasmodium falciparum gametocytes infect mosquitoes and are responsible for malaria transmission. New interventions that block transmission could accelerate malaria elimination. Gametocytes develop within erythrocytes and activate protein export pathways that remodel the host cell. Plasmepsin V (PMV) is an aspartyl protease that is required for protein export in asexual parasites, but its function and essentiality in gametocytes has not been definitively proven, nor has PMV been assessed as a transmission-blocking drug target. Here, we show that PMV is expressed and can be inhibited specifically in P. falciparum stage I-II gametocytes. PMV inhibitors block processing and export of gametocyte effector proteins and inhibit development of stage II-V gametocytes. Gametocytogenesis in the presence of sublethal inhibitor concentrations results in stage V gametocytes that fail to infect mosquitoes. Therefore, PMV primes gametocyte effectors for export, which is essential for the development and fitness of gametocytes for transmission to mosquitoes.
<title>New effects in sound generation in organic dye solutions</title> (1991)

Results of ultrashort pulse train self-diffraction are represented. Direct experiments proved the thermoacoustic nature of this phenomenon. The main features of pulse train self-diffraction (threshold characteristics, dynamics) are examined. Its influence on passively mode-locked and synchronously pumped lasers operation is considered.© (1991) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
ChemInform Abstract: SYNTHESIS AND REACTIONS OF NEW SILICON ACETOXIMATES (1977)

Abstract In Gegenwart ‐ von Magnesium und Zinn reagieren die Trichlorsilane (I) mit 3 Mol Acetonoxim (II) zu den Silanen (III).
Regions of broad-host-range plasmid RK2 which are essential for replication and maintenance (1980)

The sites of cleavage on the map of the broad-host-range plasmid RK2 (56 kilobases) were determined for the BglII, PstI, and SmaI restriction enzymes, and the determinants for tetracycline and ampicillin resistance were localized. The cleavage sites were clustered at or near the drug resistance genes. To localize regions required for plasmid replication and maintenance in Escherichia coli, we deleted nonessential regions of RK2 by partial digestion with the restriction endonuclease HaeII to produce small derivatives. The smallest stable replicon obtained contained five HaeII fragments of RK2 which total 5.4 kilobases. These fragments were derived from three regions of RK2 that are separated from each other by antibiotic resistance genes. One of these HaeII fragments (0.75 kilobases) has the properties expected of the origin of replication. The outer four fragments, located in two separate regions of RK2, were found to provide, in trans, functions that permit the replication of the HaeII fragment carrying the origin of the replication. These results indicate that at least two plasmid-encoded genes, capable of acting in trans, and a replication origin are required for RK2 replication and maintenance.
Situación actual de la rehabilitación cardíaca en Uruguay (2011)

"Introducción: las enfermedades cardiovasculares (CV) han aumentado su frecuencia siendo responsables actualmente de 30% de todas las muertes del mundo. El control y la prevención de los factores de riesgo (FR) y de los hábitos de vida no saludables son esenciales para evitar su crecimiento. En este sentido, los programas de rehabilitación cardíaca (RC) juegan un importante rol en el control de estos FR y en la prevención de nuevos eventos cardíacos. Objetivo: evaluar la situación actual de los programas de RC en Uruguay. Método: se realiza un análisis de programas de RC mediante el llenado de un cuestionario enviado a una población representativa de centros dedicados a esta disciplina. Considerando el número de pacientes internados anualmente en la Asociación Española por afecciones CV, se extrapoló a todo el país. Con este dato y el del número de pacientes que concurren a los centros de RC, se calculó el porcentaje de enfermos en rehabilitación. Resultados: de los 12 centros de RC contactados sólo se recibió respuesta de seis de ellos. Únicamente accede a estos programas menos de 4% de la población de cardiópatas elegible. La principal barrera para su desarrollo es la falta de derivación de los propios médicos. La enfermedad coronaria es la patología más frecuente entre los participantes de los programas de RC. Esta es básicamente aplicada en la fase II (66,7%) y en las fases III y IV (100%). Ningún programa ofrece rehabilitación en fase I. Alrededor de 83% de los centros de RC realiza evaluación inicial y todos estratifican, planifican y brindan consejos sobre la actividad física, nutrición y tabaquismo. Solo son derivados a psicólogo en 50% de los casos. En 83,3% de los pacientes se evalúa perfil lipídico y glicemia, sin embargo, ningún centro determina lipoproteína a, ApoAy Apo B, ni score de calcio coronario. Los profesionales involucrados son cardiólogos (100%), enfermeras (83,3%), profesores de educación física (66,7%), fisioterapeutas y nutricionistas (50%), deportólogos y psiquiatras (16,7%), todos ellos entrenados en resucitación cardíaca básica. Conclusiones: este estudio es el primer intento de evaluación de la situación de la RC en Uruguay. A pesar del reconocido valor de la misma en el cuidado de los pacientes después de un evento cardíaco, esta información muestra una baja derivación a los referidos programas y dificultades para su desarrollo, así como la imperiosa necesidad de organizar y reforzar la acción de los centros multidisciplinarios para la prevención secundaria cardíaca."
Intellectual property re-use and system emulation the keys to succeed the SoC challenge: a digital TV application (2003)

In the ICT (Information and Communication Technologies) scenario service evaluation, standard stabilization and the concurrent development of hardware and software are key elements to design innovative systems. Emulation, fast prototyping and IP re-use can really help to obtain time-to market solutions. The papers deals with an industrial MPEG/ATM remultiplexing equipment (REMUX) for digital TV applications in the SDVB (switched digital video broadcast) area for either satellite or cable distribution. The paper reports the REMUX development cycle highlighting its fast evolution from the prototype based on an embedded system to the System on Chip realization (0.25 /spl mu/m, ST Microelectronics CMOS technology), mainly focusing on the effective design methodology based on the CSELT intellectual property library (VIP/sup TM/) and system emulation.
Spectral properties of small dusty clusters (2001)

A monolayer dusty crystal can be observed in the glow discharge. In particular, a small number of dusty grains form simple atom-like plane clusters. Stability and oscillations of the polygonal cluster are considered. For the simplest stable clusters normal displacements and frequencies are found for an arbitrary form of mutual interaction. The measurement of these modes can help to give in detail the form of the potential function.
PBT/Thermoplastic Elastomer Blends—Mechanical, Morphological, and Rheological Characterization (2008)

The blends of poly(butylene terephthalate) (PBT) with thermoplastic elastomer (TPE) at a blending composition of 10–30 wt.% TPE were prepared with an objective to enhance impact toughness of PBT. Two different grades of PBT were selected based on carboxyl end group and viscosity. Melting behavior, mechanical properties, morphology, and rheology of the blends were studied. At all levels of TPE, PBT showed negligible changes in its melting and crystallization temperature; however, percentage crystallinity decreased with an increase in the amount of thermoplastic elastomer. The notched as well as unnotched Izod impact strength of PBT increased with the incorporation of TPE, the increase being about 47% (unnotched) and 54% (notched) with low molecular weight PBT and 18% (unnotched) and 70% (notched) with high molecular weight PBT at 10% TPE level. The tensile strength and tensile modulus of the blends decreased steadily as the weight percent of TPE increased. Analysis of the tensile data using predicted theories indicated that at TPE levels of 30 wt.%, the blends cannot take excessive stress because the interfacial adhesion is lowered. Small angle light scattering (SALS) studies of the samples indicated the decreased rate of crystallization and, hence, an increase in spherulitic radius in the presence of TPE. The increasing incorporation of TPE in PBT/TPE blends increased the shear thinning behavior and hence eased processability.
Defect Transfer GAN: Diverse Defect Synthesis for Data Augmentation (2023)

Data-hunger and data-imbalance are two major pitfalls in many deep learning approaches. For example, on highly optimized production lines, defective samples are hardly acquired while non-defective samples come almost for free. The defects however often seem to resemble each other, e.g., scratches on different products may only differ in a few characteristics. In this work, we introduce a framework, Defect Transfer GAN (DT-GAN), which learns to represent defect types independent of and across various background products and yet can apply defect-specific styles to generate realistic defective images. An empirical study on the MVTec AD and two additional datasets showcase DT-GAN outperforms state-of-the-art image synthesis methods w.r.t. sample fidelity and diversity in defect generation. We further demonstrate benefits for a critical downstream task in manufacturing -- defect classification. Results show that the augmented data from DT-GAN provides consistent gains even in the few samples regime and reduces the error rate up to 51% compared to both traditional and advanced data augmentation methods.
Bismuth nano-droplets for group-V based molecular-beam droplet epitaxy (2011)

Self-assembly of bismuth droplets at nanoscale on GaAs(100) surface using molecular beam epitaxy was demonstrated. Fine control of density and size was achieved by varying growth temperature and total bismuth deposition. Droplet density was tuned by roughly 3 orders of magnitude, and the density-temperature dependence was found to be consistent with classical nucleation theory. These results may extend the flexibility of droplet epitaxy by serving as templates for group V based droplet epitaxy, which is in contrast to conventional group III based droplet epitaxy and may encourage nanostructure formation of bismuth-containing materials.
Emisiones otoacústicas y métodos de screeningauditivo en recién nacidos (2003)

Con el transcurrir del tiempo, han habido grandes avances en la tecnologia de miniaturizacion de equipos, en la aparicion de software de interpretacion, y la simplificacion de los metodos de ejecucion. Se han desarrollado ademas, nuevos examenes auditivos como las emisiones otoacusticas que han permitido una mayor y mejor deteccion, con alto grado de especificidad y sensibilidad. Esto ha hecho posible que la pesquisa precoz sea posible y se este convirtiendo en una realidad a traves del mundo.
A cryopreservation protocol for embryos of the endangered species Zizania texana. (2003)

Seeds of the endangered species Zizania texana are recalcitrant, making it difficult to preserve the remaining genetic diversity of this species in genebanks. Excised embryos can be cryopreserved using solution-based cryoprotection protocols. Survival following cryoexposure increased from less than 5% to about 75% by preculturing embryos in high concentrations of sugars, bathing them in cryoprotectant solutions, and partially drying them to water contents of about 0.6 g H2O/g dry mass.
Synthesis and properties of copper quinonoid complexes for optical recording application (2006)

We describe the synthesis of novel quinonemonimines Cu(II) coordination complexes, of the type: which, in addition to their intrinsic interest, have potential application in optical recording. The following key parameters have been highlighted: ( i ) the presence of coordinating arms on the quinonoid core of the ligand leads to octahedral complexes with increased solubility, ( ii ) the presence of Cu(II) as a metal centre leads to a favourable exothermic decomposition, ( iii ) the presence of quinonoid moieties results in the optical absorption to be in the desired wavelength range. .
Emergency department thoracotomy for the critically injured patient: Objectives, indications, and outcomes (2006)

In the past three decades there has been a significant clinical shift in the performance of emergency department thoracotomy (EDT), from a nearly obligatory procedure before declaring any trauma patient to select patients undergoing EDT. The value of EDT in resuscitation of the patient in profound shock but not yet dead is unquestionable. Its indiscriminate use, however, renders it a low-yield and high-cost procedure. Overall analysis of the available literature indicates that the success of EDT approximates 35% in the patient arriving in shock with a penetrating cardiac wound, and 15% for all penetrating wounds. Conversely, patient outcome is relatively poor when EDT is done for blunt trauma; 2% survival in patients in shock and less than 1% survival with no vital signs. Patients undergoing CPR upon arrival to the emergency department should be stratified based upon injury and transport time to determine the utility of EDT. The optimal application of EDT requires a thorough understanding of its physiologic objectives, technical maneuvers, and the cardiovascular and metabolic consequences.
ChemInform Abstract: Control of Biogenic Nanocrystal Formation in Biomineralization (2016)

Abstract Review: 109 refs.
Equinovarus in Cerebral Palsy (2013)

Equinovarus foot and ankle deformity is most common in children diagnosed with hemiplegic cerebral palsy (CP). A child with equinovarus is limited in gross motor functional skills which can lead to further disability. The cause of this deformity is believed to result from a combination of neuromuscular and biomechanical impairments secondary to an insult to the developing central nervous system. Non-phasic activity of the extrinsic musculature surrounding the foot and ankle create muscular imbalance, atypical positioning and motion of the foot and ankle during locomotion. \nThis dissertation consisted of three experiments that provided fundamental insights into the segmental foot and ankle kinematics during locomotion of children with equinovarus secondary to hemiplegic CP. The first experiment showed that temporal-spatial parameters and triaxial hindfoot kinematics were not affected by the presence of a fine wire electrode inserted into the posterior tibialis. Thus, simultaneous collection of segmental foot and ankle kinematics and fine wire EMG data of the posterior tibilais is acceptable for surgical decision making in this population. \nThe second experiment used a combination of segmental foot and ankle kinematics, principal component analysis (PCA), and K-means cluster analysis to examine the gait deviations associated with the equinovarus foot. Five clinically recognizable subgroups were identified with unique segmental involvement, planar motion, and range of motion (ROM).\nThe third experiment used principal component scores obtained in Experiment 2 to describe changes in segmental foot and ankle motion during walking that resulted from surgical soft tissue balancing procedures for equinovarus. The relationship between segmental foot and ankle kinematics and walking velocity was also evaluated. The results demonstrated that surgical soft tissue balancing procedures result in more neutral hindfoot and forefoot gait kinematics. Individual cases of uncorrected deviations were attributed to two causes: (1) the specific segmental deformity was not identified pre-operatively, and therefore not surgically addressed, and (2) the deformity was so severe that a soft tissue balancing procedure could not correct it. Surgery did not have an effect on walking velocity, and correlation analysis demonstrated that increases in walking velocity were associated with increases in sagittal plane hindfoot range of motion.
The chemistry of thujone. XVI. Versatile and efficient routes to safronitrile, β-cyclogeranonitrile, β-cyclocitral, damascones, and their analogues (1992)

Thujone, a waste by-product of the Canadian forest industry, has been utilized as a starting material to develop a versatile synthetic route to the damascones (rose oil ketones) and related analogues. The synthetic sequence provides a route to β-cyclocitral (45), the latter having been previously converted to β-damascone (2). In addition, thujone-derived intermediates are converted to β-damascenone (48) and to intermediates that can be utilized for the preparation of damascone analogues. In conjunction with the above, an efficient route to safronitrile (42), β-cyclogeranonitrile (43), and β-cyclocitral (45) from 2,6-dimethylcyclohexanone has been developed. In summary, these studies afford an attractive versatile route to these important perfumery materials.
Optimisations structurelles et matérielles de l'encodeur vidéo H264/AVC sur un seul coeur d'un DSP multicoeurs TMS320C6472 (2013)

International audience
Solution and solid-phase chemoselective synthesis of (1-6)-amino(methoxy) di- and trisaccharide analogues (2002)

Disaccharide and trisaccharide mimics containing the amino(methoxy) interglycosidic linkage were obtained by chemoselective condensation of unprotected aldoses in an aqueous environment both in solution and in solid phase.