gebhart/patrepeval huggingface dataset:
Simultaneous atomic force microscopy measurement of topography and contact resistance of metal films and carbon nanotubes (2003)

We present a quartz tuning-fork-based atomic force microscopy (AFM) setup that is capable of mapping the surface contact resistance while scanning topography. The tuning-fork setup allows us to use etched Pt/Ir tips, which have higher durability and better conductivity than probes used in earlier AFM conductance measurements. The performance of the method is demonstrated with contact resistance measurements of gold lines on silicon dioxide and carbon nanotubes on graphite.
Contribution to COBS synchronization with PTP IEEE std. 1588 (2013)

This work presents a cabled system for collecting real-time seismic data on the coastal zones. It is deployed in the Western Mediterranean Cabled Observatory, OBSEA (www.obsea.es). A key component in this cabled system, COBS, is the use of IEEE standard 1588 that serves as a clock synchronization mechanism for the seismometer with Universal Time Coordinates (UTC) clock. Delivering of accurate timing to the seismometer, the seismic data can be time stamped using a UTC clock which is traceable to within the desired level of precision of sub milliseconds necessary for an accurate location of an earthquake.
Measurement of adsorption constants of laccase on gold nanoparticles to evaluate the enhancement in enzyme activity of adsorbed laccase (2018)

Adsorption of enzymes to nanoparticles and the mechanisms responsible for enzyme activity modulation of adsorbed enzymes are not well understood. In this work, gold nanoparticles were used for electrostatic adsorption of a plant-derived laccase. Adsorption constants were determined by four independent techniques: dynamic light scattering, electrophoretic light scattering, agarose gel electrophoresis and fluorescence quenching. Stable bionanoconjugates were formed with log K in the range 6.8-8.9. An increase in enzyme activity was detected, in particular at acidic and close to neutral pH values, a feature that expands the useful pH range of the enzyme. A model for the adsorption was developed, based on geometrical considerations and volume increase data from dynamic light scattering. This indicates that enzymes adsorbed to gold nanoparticles are ca. 9 times more active than the free enzyme.
A Guard Interval Control Scheme Using Theoretical System Capacity for UAV MU-MIMO-OFDM THP Systems (2022)

This paper proposes a guard interval (GI) control scheme using the theoretical system capacity for unmanned aerial vehicle (UAV) multi-user multiple-input and multiple-output orthogonal frequency-division multiplexing (MU-MIMO-OFDM) Tomlinson-Harashima precoding (THP) systems. Considering the need for coverage extension assumed in sixth-generation mobile communication systems (6G), we consider UAVs as users as well. Therefore, variation in delay spread between users is assumed to increase due to differences in the communication distance and flight height. In such scenarios, GI length is typically determined from the longest delay among all mobile stations (MSs) to eliminate inter-symbol interference (ISI). However, this leads to significant degradation in transmission efficiency. The proposed scheme adopts a GI length that maximizes the theoretical system capacity derived from the correlation calculation while allowing some ISI, which reduces transmission overhead. Moreover, considering the assumed spatial correlation, particularly in UAV communications, THP is adopted as the MU-MIMO precoding method. The effectiveness of the proposed scheme is demonstrated via computer simulations in comparison with the traditional scheme adjusted to the largest multipath delay.
Implementation of a rule-based routing protocol for wireless sensor networks (2007)

In this paper, we make a study of a routing algorithm for wireless sensor networks. We have developed a micaZ-based real sensor network to know the major problems with this kind of networks. Firstly, we are interested on routing algorithms implemented in TinyOS. After this preliminary analysis phase, we have studied some optimizations over the routing implementations and we have tried them obtaining an important prolongation of network lifetime.
the God That Succeeded (2010)

Abstract This introductory chapter presents the argument that science fiction and fantasy—particularly narratives drawn from media—are often dismissed as unserious and trivial. This refers to the comic book and the science fiction film. In contrast, these, this book argues, are capable of achieving profound and probing insights into the principal dilemmas of political life. The book examines the hypothetical transformations and imaginary upheavals overtaking fictitious individuals and societies. It explores themes such as the foundation of new political orders, the endeavor to realize utopia, the necessities behind tyranny, the relationship of a saintly politics to the practice of realpolitik, and the potential and limitations of radical politics in the present age. Science fiction, therefore, can serve as a vital instrument for the investigation of the contingencies governing political life, the forces that structure and dissolve collective existence, by providing the reader with visions, in which familiar realities are destabilized and transformed.
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis (2001)

Mitogen-activated protein kinase (MAPK) cascades are involved in inflammation and tissue destruction in rheumatoid arthritis (RA).In particular, c-Jun N-terminal kinase (JNK) is highly activated in RA fibroblast-like synoviocytes and synovium.However, defining the precise function of this kinase has been difficult because a selective JNK inhibitor has not been available.We now report the use of a novel selective JNK inhibitor and JNK knockout mice to determine the function of JNK in synoviocyte biology and inflammatory arthritis.The novel JNK inhibitor SP600125 (anthra[1,9-cd]pyrazol-6(2H)-one) completely blocked IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription in synoviocytes.Furthermore, AP-1 binding and collagenase mRNA accumulation were completely suppressed by SP600125.In contrast, complete inhibition of p38 had no effect, and ERK inhibition had only a modest effect.The essential role of JNK was confirmed in cultured synoviocytes from JNK1 knockout mice and JNK2 knockout mice, each of which had a partial defect in IL-1-induced AP-1 activation and collagenase-3 expression.Administration of SP600125 modestly decreased the rat paw swelling in rat adjuvant-induced arthritis.More striking was the near-complete inhibition of radiographic damage that was associated with decreased AP-1 activity and collagenase-3 gene expression.Therefore, JNK is a critical MAPK pathway for IL-1-induced collagenase gene expression in synoviocytes and in joint arthritis, indicating that JNK is an important therapeutic target for RA.
Prevalence of Inhibitors in a Population of 3435 Hemophilia Patients in France (1992)

A cooperative study between the 37 centers of the French Hemophilia Study Group was undertaken to establish the prevalence of inhibitor patients in the French hemophilia population. The prevalence reported in the literature varies widely from 3.6% to 17.5%. Some of the studies are dealing with a small number of patients and inhibitor patients are reported either to the total number of hemophiliacs or to the severely affected ones. The French study provided information concerning 3,435 hemophiliacs and showed a prevalence of 6.2% for the overall population. Prevalence of inhibitors was found to be 7% in the population of hemophilia A patients and 12.8% in the population of severely affected ones. The prevalence of inhibitors in the population of hemophilia patients was 2% and 4% in the population of severely affected hemophilia B patients. The cooperative study also showed that 47.5% of inhibitors are detected before 10 years of age and that 82% of inhibitor patients are high responders. Analysis of inhibitor detection in patients under the age often showed that there was a peak in the population of 2 years old children. Although not comparable to the present study the high incidence of inhibitors with ultrapurified and recombinant FVIII reported in previously untransfused patient may be borne in mind.
ConvNet Transfer Learning for GPR Images Classification (2020)

The ground penetrating radar (GPR) is an important tool for detecting and defining buried objects. One of the main problems facing this method is the high probability of false alarms, therefor proper signal processing has to be considered. In this paper, the matched filter algorithm has been implemented to process the GPR data. After processing the data and detecting the underground reflections, further processing is mandatory to classify these reflections, therefore, a convolutional neural network (ConvNet) is presented for classifying these responses. The ConvNets are considered as the best artificial intelligence algorithms for image classification problems. Generally, a ConvNet requires a very large number of images to be trained well and to achieve the best results. To overcome the problem of having a limited amount of the GPR data, the ConvNet has been trained on another popular dataset, which is the Fashion-MNIST, and then transfer learning is applied to use the learned features of the network with the limited GPR dataset. The network performance has been monitored and the classification results show a high degree of precision and accuracy.
Synthesis of zirconocene-acetylene and zirconocene-diacetylene polymer (1999)

A new class of organometallic polymer having a backbone of conjugated Poly-yne and Zr-metal atoms has been prepared. Trichloroethylene (TCE) and Hexachlorobutadiene (HCB) are quantitatively converted by n-butyllithium to dilithioacetylene (LiCCLi) and dilithiodiacetylene (LiCCCCLi) respectively. Quenching with Cp2*ZrCl2 affords high yields of the polymers Zr(Cp2*)CCn and Zr(Cp2*)CCCCn where Cp* = C5(CH3)5 = pentamethyl cyclopentadienyl. The Cp2*ZrCl2 and the polymers were characterized by viscosity, molecular weight, elemental analysis, FTIR, NMR spectra, and TGA. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 3899–3902, 1999
Increased expression profile of NCSTN, Notch and PI3K/AKT3 in hidradenitis suppurativa (2020)

We found no evidence for diminished expression levels of the Notch signalling. In contrast, the NCSTN, Notch and PI3K/AKT signalling components are overexpressed in HS. Future research is needed to investigate a possible pathogenetic role or to reveal a coactivation of these overexpressed components during inflammatory response in HS.
La tularémie : situation en France, problématiques et risques en santé publique (2006)

Tularemia : situation in France, issues and public health risk This is a retrospective study on natural foci of tularemia in animals as well as human cases reported in France between 1999 and 2004. Since 1999, approximately 20 to 60 animals foci of infection in hares are detected every year in 19 to 34 French departments. Human cases often occur in areas where animal foci have erupted, but not always. There are several reasons explaining the presence of this disease on French territory, its underestimation in animals, and probably in man, and its durability. The disease is generally poorly recognised, except amongst shooters who are aware of its existence. Several clinical forms are known in man, sometimes with severe symptoms. The diagnosis of tularemia can be difficult due to its non-specific clinical features. Tularemia is mostly described in hares but other species can be also affected, serving as reservoirs for the infection and sometimes acting as vectors as well. The animal population tested for tularemia should be widened to include other wild species, as well as some of our domestic animals. In man, this diagnosis should be considered in people presenting certain clinical signs. A background on epidemiological data is given. In addition, as Francisella tularensis is one of the bioterrorism agents, it is essential that clinicians and biologists recognise this bacteria and are aware of its dangers. Tularemia was removed from the list of Legally Contagious Disease in veterinary medicine in 1996. It has become a notifiable disease in human medicine in 2002.
Relations between CSCW and software process research: a position statement (1995)

The field of CSCW is investigating computer support for arbitrary, distributed cooperative work while the field of software process is focusing on control and automation of the activities of collaborating software engineers. We look at the scope and important ideas of these fields and address the following questions: are software process and CSCW two approaches for the same research field? Are the two fields taking incompatible approaches to solve the same problem? Can each field help the other to better meet its goals? We explore the possibility of integrating our solutions. We give only preliminary answers to these questions and hope that by raising these questions we can develop better answers and a concrete plan to integrate our own efforts and those of other participants in the workshop.
Dual lattice attacks for closest vector problems (with preprocessing). (2021)

The dual attack has long been considered a relevant attack on lattice-based cryptographic schemes relying on the hardness of learning with errors (LWE) and its structured variants. As solving LWE corresponds to finding a nearest point on a lattice, one may naturally wonder how efficient this dual approach is for solving more general closest vector problems, such as the classical closest vector problem (CVP), the variants bounded distance decoding (BDD) and approximate CVP, and preprocessing versions of these problems. While primal, sieving-based solutions to these problems (with preprocessing) were recently studied in a series of works on approximate Voronoi cells [Laa16b, DLdW19, Laa20, DLvW20], for the dual attack no such overview exists, especially for problems with preprocessing. With one of the take-away messages of the approximate Voronoi cell line of work being that primal attacks work well for approximate CVP(P) but scale poorly for BDD(P), one may further wonder if the dual attack suffers the same drawbacks, or if it is perhaps a better solution when trying to solve BDD(P).
Silibinin Protects against Photocarcinogenesis via Modulation of Cell Cycle Regulators, Mitogen-Activated Protein Kinases, and Akt Signaling (2004)

Here, we assessed the protective effect of silibinin on UVB-induced skin carcinogenesis in SKH-1 hairless mice. Topical application of silibinin before or immediately after UVB exposure or its dietary feeding resulted in a strong protection against photocarcinogenesis, in terms of tumor multiplicity (60-66%; P < 0.001), tumor volume per mouse (93-97%; P < 0.001) and tumor volume per tumor (80-91%; P < 0.001). Silibinin also moderately inhibited tumor incidence (5-15%; P < 0.01) and delayed tumor latency period (up to 4 weeks; P < 0.01-0.001). To investigate in vivo molecular mechanisms of silibinin efficacy, tumors and uninvolved skin from tumor-bearing mice were examined immunohistochemically for proliferation, p53, apoptosis, and activated caspase-3. Silibinin treatment showed a strong decrease (P < 0.001) in proliferating cell nuclear antigen-positive cells and an increase in p53-positive (P < 0.005-0.001), terminal deoxynucleotidyltransferase-mediated nick end labeling-positive (P < 0.005-0.001), and cleaved caspase-3-positive cells (P < 0.001). Western blot analysis of normal skin and tumor lysates showed that silibinin decreases the levels of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 and associated cyclins A, E, and D1, together with an up-regulation of Cip1/p21, Kip1/p27, and p53. Silibinin also showed a strong phosphorylation of extracellular signal-regulated protein kinase 1/2, stress-activated protein kinase/c-JUN NH2-terminal kinase 1/2, and p38 mitogen-activated protein kinases but inhibited Akt phosphorylation and decreased survivin levels with an increase in cleaved caspase-3. Together, these results show a strong preventive efficacy of silibinin against photocarcinogenesis, which involves the inhibition of DNA synthesis, cell proliferation, and cell cycle progression and an induction of apoptosis. Furthermore, these results also identify in vivo molecular mechanisms of silibinin efficacy against photocarcinogenesis.
Microspectrometer Fabricated by the Liga Process (1993)

The Liga process can be used to pattern light guiding polymer layers with high accuracy, enabling planar grating spectrographs with self-focusing reflection gratings consisting of step heights as small as 0·2 μm with a total structure height of 125 μm to be fabricated. These grating spectrographs can be used for optical analysis over the entire visible and near infrared (up to 1100 nm) wavelength regions; the transmitted intensity is about 25%. They can be adapted easily to a diode array by using total internal reflection at an inclined sidewall also fabricated by the Liga process. In this case the spectral resolution may be in the order of 1–4 nm per diode pixel.
Finite element modeling in surgery simulation (1998)

Modeling the deformation of human organs for surgery simulation systems has turned out to be quite a challenge. Not only is very little known about the physical properties of general human tissue but in addition, most conventional modeling techniques are not applicable because of the timing requirements of simulation systems. To produce a video-like visualization of a deforming organ, the deformation must be determined at rates of 10-20 times/s. In the fields of elasticity and related modeling paradigms, the main interest has been the development of accurate mathematical models. The speed of these models has been a secondary interest. But for surgery simulation systems, the priorities are reversed. The main interest is the speed and robustness of the models, and accuracy is of less concern. Recent years have seen the development of different practical modeling techniques that take into account the reversed priorities and can be used in practice for real-time modeling of deformable organs. The paper discusses some of these new techniques in the reference frame of finite element models. In particular, it builds on the recent work by the author on fast finite element models and discusses the advantages and disadvantages of these models in comparison to previous models.
Microfluidic-based patterning of embryonic stem cells for in vitro development studies (2013)

In vitro recapitulation of mammalian embryogenesis and examination of the emerging behaviours of embryonic structures require both the means to engineer complexity and accurately assess phenotypes of multicellular aggregates. Current approaches to study multicellular populations in 3D configurations are limited by the inability to create complex (i.e. spatially heterogeneous) environments in a reproducible manner with high fidelity thus impeding the ability to engineer microenvironments and combinations of cells with similar complexity to that found during morphogenic processes such as development, remodelling and wound healing. Here, we develop a multicellular embryoid body (EB) fusion technique as a higher-throughput in vitro tool, compared to a manual assembly, to generate developmentally relevant embryonic patterns. We describe the physical principles of the EB fusion microfluidic device design; we demonstrate that >60 conjoined EBs can be generated overnight and emulate a development process analogous to mouse gastrulation during early embryogenesis. Using temporal delivery of bone morphogenic protein 4 (BMP4) to embryoid bodies, we recapitulate embryonic day 6.5 (E6.5) during mouse embryo development with induced mesoderm differentiation in murine embryonic stem cells leading to expression of Brachyury-T-green fluorescent protein (T-GFP), an indicator of primitive streak development and mesoderm differentiation during gastrulation. The proposed microfluidic approach could be used to manipulate hundreds or more of individual embryonic cell aggregates in a rapid fashion, thereby allowing controlled differentiation patterns in fused multicellular assemblies to generate complex yet spatially controlled microenvironments.
Participation of cyclin A in Myc-induced apoptosis. (1994)

The involvement of c-Myc in cellular proliferation or apoptosis has been linked to differential cyclin gene expression. We observed that in both proliferating cells and cells undergoing apoptosis, cyclin A (but not B, C, D1, and E) mRNA level was elevated in unsynchronized Myc-overexpressing cells when compared with parental Rat1a fibroblasts. We further demonstrated that Zn(2+)-inducible cyclin A expression was sufficient to cause apoptosis. When Myc-induced apoptosis was blocked by coexpression of Bcl-2, the levels of cyclin C, D1, and E mRNAs were also elevated. Thus, while apoptosis induced by c-Myc is associated with an elevated cyclin A mRNA level, protection from apoptosis by coexpressed Bcl-2 is associated with a complementary increase in cyclin C, D1, and E mRNAs.
Efficient Two-Step Syntheses of Sulfonylguanidines from Sulfonamides (1996)

Abstract Various sulfonylguanidines have been synthesized from a sulfonamide by two mild and efficient synthetic methods. In route A, the methylthio group of S-methylsulfonylisothiourea is displaced by a variety of amines while in route B the amines are reacted with sulfonylthiourea in the presence of mercury oxide HgO.
Efficient lifetime management of SSD-based RAIDs using dedup-assisted partial stripe writes (2016)

For SSD-based RAID systems, the Diff-RAID technique has been proposed to reduce the probability of correlated multiple failures among SSDs by differentiating the amount of written data to each SSD. Although Diff-RAID works well for workloads with many small random writes (which require frequent parity updates), it does not perform well with recent data center workloads (e.g., key-value stores) which are dominated by large sequential writes (i.e., full stripe writes). In order to efficiently differentiate the amount of written data to each SSD for data center workloads, full stripe writes should be converted to partial stripe writes. However, a naive solution such as using a large chunk size significantly degrades the lifetime of SSDs because of a large increase in parity updates. In this paper, we propose a new lifetime management technique, DA-RAID, which overcomes the limitation of Diff-RAID by using deduplication-assisted partial stripe writes. In DA-RAID, a full stripe write can be converted to a partial stripe write so that the age differentiation among SSDs can be supported without increasing the amount of parity updates. Our experimental results show that DA-RAID can effectively sustain the age difference among SSDs even for data center workloads (for which Diff-RAID fails) without additional parity updates. DA-RAID achieves similar age differences among SSDs as Diff-RAID with a large chunk size while reducing the amount of parity updates by 32% over Diff- RAID.
PI-04 SURGEON AND HOSPITAL VARIATION IN THE COSTS OF ROBOT-ASSISTED RADICAL PROSTATECTOMY IN THE UNITED STATES (2016)

continence is related to the individual surgeon technique rather than the sling procedure. Further follow up is ongoing to determine long term impact on continence.