gebhart/patrepeval huggingface dataset:
A prospective study of sodium-lithium countertransport and hypertension in Utah. (1991)

A 7-year prospective study of a cohort of 1,458 normotensive adults from Utah pedigrees, screened from 1980 to 1985, was done to determine whether baseline levels of sodium-lithium countertransport were associated with an increased risk of future hypertension. Subsequent new hypertension (n = 39) was ascertained in 1989 from detailed follow-up medical questionnaires (67% response). Previous segregation analyses on a subset of these pedigree members who responded (n = 342) using family relationships in addition to countertransport levels have shown statistically inferred major gene segregation of sodium-lithium countertransport levels. In the normotensive adults inferred by segregation analysis to carry the recessive major gene for high sodium-lithium countertransport, new-onset hypertension occurred in 18.8% (3 of 16) compared with 3.7% (12 of 326) in the low sodium-lithium countertransport genotype group (relative risk, 4.6 [1.6, 13.9]; p = 0.03). However, an elevated baseline sodium-lithium countertransport level without genotype information from segregation analysis did not increase the risk of future hypertension in the complete cohort of adult pedigree members (relative risk, 1.02 [0.85, 1.22]). Adjustment for other risk factors reduced the relative risk to 0.90 (0.72, 1.11). We conclude that the presence of a major gene for sodium-lithium countertransport or another closely linked gene, rather than the actual level of sodium-lithium countertransport, may increase the risk of hypertension onset. High sodium-lithium countertransport levels do not increase the risk of future hypertension for individuals in whom only polygenic and environmental effects determine sodium-lithium countertransport level.(ABSTRACT TRUNCATED AT 250 WORDS)
A Characteristic of Spherical Indentation Curve and its Application in Measuring Material Properties (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Modelling helical screw piles in clay using a transparent soil (2010)

Physical modelling involving the use of transparent synthetic clay, laser aided tomography, digital imaging and particle image velocimetry (PIV) is currently being undertaken to investigate more fully the differences of deep helical screw pile behaviour caused by varying the s/D ratio and to assess the validity of assuming a cylindrical failure surface between helical plates in design. The paper outlines the modelling techniques and reports some initial results.
New approach to data preparation and processing for high-density patterns (1997)

A modern pattern generator needs very high data-handling capacity, partly because the number of features per mask is growing, partly because OPC and other sophisticated lithographic enhancements increase the complexity. MICRONIC makes a wide range of laser pattern generators for display, reticles and other electronics applications, and therefore needs a hardware/software datapath that is configurable over a wide range of requirements and cost levels. An extendible multiprocessor architecture offers this flexibility: possibility for multiprocessing for very high power, and at the same time ability to configure small systems for low-end applications. Preliminary benchmarks show a speed increase over previous systems by 10 to 60 times for a single processor.
Mechanical property characterization of multidirectional Si{sub 3}N{sub 4}/BN fibrous monoliths. (1999)

Fibrous monoliths (FMs) of Si{sub 3}N{sub 4}/BN ({approx}85 vol% Si{sub 3}N{sub 4}/15 vol% BN) with three different cell architectures (unidirectional, 0{degree}/90{degree}, and {+-}45{degree}) were tested in four-point-bend mode under ambient conditions. The FM constituents (hot-pressed monolithic Si{sub 3}N{sub 4} and BN) were also characterized. The unidirectional Si{sub 3}N{sub 4}/BN FM demonstrated the best properties, with ultimate strength of 476 {+-} 30 MPa and work-of-fracture of 12.6 {+-} 1.9 kJ/m{sup 2}, while Si{sub 3}N{sub 4}/BN FM with {+-}45{degree} cell architecture had the lowest strength (175 {+-} 13 MPa) and work-of-fracture (2.7 {+-} 1.7 kJ/m{sup 2}). The 0{degree}/90{degree} FM had intermediate values of 379 {+-} 86 MPa and 4.9 {+-} 2.2 kJ/m{sup 2}. High work-of-fracture for the unidirectional Si{sub 3}N{sub 4}/BN was correlated to toughening mechanisms such as extensive delamination and crack deflection. Predictions for the elastic moduli of the Si{sub 3}N{sub 4}/BN FMs based on laminate theory correlated well with the observed elastic moduli for the unidirectional and 0{degree}/90{degree} Si{sub 3}N{sub 4}/BN FMs. However, large discrepancies were observed between predictions and observed values for the {+-}45{degree} Si{sub 3}N{sub 4}/BN FMs, possibly due to the increasing role of the BN phase on mechanical properties in these FMs. Mechanical properties of monolithic Si{sub 3}N{sub 4} and BN compared well with literature values.
Using Sentinel Lymph Node Biopsy to Guide Treatment Algorithms in Clinically N0 Sinonasal Malignancy (2023)

Introduction: Early stage (T1 and T2) clinically N0 patients with sinonasal squamous cell carcinoma present a treatment dilemma with regards to elective treatment of the neck. Even in situations with low incidence of nodal metastasis, radiation oncologists may elect to radiate bilateral locoregional lymphatic basins in the adjuvant setting. We propose the inclusion of lymphoscintigraphy in the treatment algorithm of sinonasal malignancy for sampling of the primary echelon nodal basin. A positive result would lead toward lymphadenectomy while a negative nodal pathologic analysis may help argue against unnecessary external beam radiation.
SOI based integrated on-chip photonic pressure sensor (2012)

A compact, mass producible Silicon On Insulator (SOI) based pressure sensor consisting of a folded Micro Ring Resonator (MRR) on a circular diaphragm is successfully designed, fabricated and characterized [1-3]. The MRR is designed to be single mode for TE polarized light at 1550 nm. The folded MRR has a total length of 1500 μm which is folded to cover an area of 50X400 μm2 and has a guide-width of 450 nm. The circular diaphragm having a diameter of 1350 μm and a thickness of 15 μm is fabricated by reactive ion etching from the substrate side. Light is coupled into the MRR through the “in” port and measured at the “through” port using grating couplers. An application of pressure deflects the membrane, causing stress in the MRR, which in turn changes the effective refractive index the waveguide [4]. This results in a shift in its resonant wavelengths, which represent the applied pressure. Figure 1A shows the measured linear dependence between the resonance wavelength shift and the applied pressure at a constant temperature. Figure 1 B shows a SEM image of part of the membrane with MRR and Figure 1 C shows a schematic of the folded MRR. Such a pressure sensor finds applications in environments in which only minimal invasion is tolerated, such as in medical instrumentation.
Network slicing as a service: enabling enterprises' own software-defined cellular networks (2016)

With the blossoming of network functions virtualization and software-defined networks, networks are becoming more and more agile with features like resilience, programmability, and open interfaces, which help operators to launch a network or service with more flexibility and shorter time to market. Recently, the concept of network slicing has been proposed to facilitate the building of a dedicated and customized logical network with virtualized resources. In this article, we introduce the concept of hierarchical NSaaS, helping operators to offer customized end-to-end cellular networks as a service. Moreover, the service orchestration and service level agreement mapping for quality assurance are introduced to illustrate the architecture of service management across different levels of service models. Finally, we illustrate the process of network slicing as a service within operators by typical examples. With network slicing as a service, we believe that the supporting system will transform itself to a production system by merging the operation and business domains, and enabling operators to build network slices for vertical industries more agilely.
Modeling and implementation of on-chip millimeter-wave compact branch line couplers in a BiCMOS technology (2007)

In this paper, the modeling, design, and measurement of on-chip compact millimeter-wave branch line couplers are discussed. These couplers are realized with the Back End of Line (BEOL) wiring and enabled as a library device of a 0.13 micron SiGe BiCMOS process design kit. Like other library devices, this coupler device has a scalable layout pattern and a schematic symbol, which allows users to have couplers at different frequencies by inputting the dimensions. An accurate model for these branch line couplers is developed, which shows a good match with the measurements of the couplers designed for 60GHz, 77GHz and 94GHz. Better than 19dB return loss, better than 1.5dB insertion loss and better than 21dB isolation have been observed. The side dimensions of these compact on-chip couplers are ranging from 440 microns to 530 microns.
The endothelial cell protein receptor: a two-faced receptor, between coagulation and inflammation (2002)

The protein C (PC) pathway plays a critical role in the regulation of coagulation and modulation of inflammation. An endothelial cell receptor (named EPCR) was recently discovered, and was shown to bind the zymogen as well as the active form of PC (aPC) with identical affinities. The identification of this receptor allowed several elusive points to be clarified. Up to now, the anticoagulant PC pathway was thought to act essentially in the microcirculation while discovery of EPCR at the surface of large vessels highlights also the role of this pathway on the entire vascular system. Indeed, the activation rate of EPCR-bound PC by the thrombin-thrombomodulin (IIa-TM) complex is three to five-fold higher than that of circulating PC by the IIa-TM complex, counterbalancing the apparent low concentration of thrombomodulin in large vessels. In addition, aPC binding to EPCR decreases tissue-factor expression, thus limiting procoagulant activity of endothelial cells. This receptor could be one of the missing links explaining the anti-inflammatory effect of aPC. A recent study evidenced several intracellular mechanisms elucidating the anti-inflammatory effects of aPC infusion, and EPCR could be responsible for signal transduction. EPCR is related to MHC class I molecules, a family of transmembrane proteins able to bind peptides. The binding of PC to EPCR is mostly conditioned by the Gla domain of PC, and is independent of the presence of anionic phospholipids. Thus, the presence of procoagulant surface is not a prerequisite for PC activation. As for thrombomodulin, a soluble form of EPCR (sEPCR) is present under physiological conditions, and corresponds to a truncated form of the cellular protein released from the vascular wall by a constitutive proteolysis. The sEPCR is able to bind PC as well as aPC with identical Kd. It increases slightly the catalytic activity of aPC toward chomogenic substrates. Soluble EPCR also modulates the inflammatory response, by binding to CD11b-CD18 and PR-3 proteins expressed by activated neutrophils, thus precluding neutrophil adhesion. Additional investigations are required to further evaluate the importance of this receptor in human pathology. However, gene knock-out experiments in mice and in vivo studies in different animal models, indicate that EPCR should play a critical role in both coagulation and inflammation.
Contribution of toxic cyanobacteria to massive deaths of Lesser Flamingos at saline-alkaline lakes of Kenya (2005)

(2005). Contribution of toxic cyanobacteria to massive deaths of Lesser Flamingos at saline-alkaline lakes of Kenya. SIL Proceedings, 1922-2010: Vol. 29, No. 2, pp. 783-786.
Figure S6 from Engineered Adoptive T-cell Therapy Prolongs Survival in a Preclinical Model of Advanced-Stage Ovarian Cancer (2023)

&lt;p&gt;Figure S6: Cytoxan pre-treatment alters the makeup of immune-suppressive cells in ID8VEGF tumors.&lt;/p&gt;
Spectral absorption model for Tm:Lu2O3 ceramic edge-pumped disk lasers (2017)

Tm:Lu2O3 has a multi–featured absorption spectrum in the usual pump band around 796 nm with peaks and valleys narrower than the bandwidth of conventional pump diodes in this range. As a result, accurate prediction of the spatial deposition of absorbed pump power is rather challenging. This is of particular importance for the edge-pumped disk laser where the spatial gain profile is adjusted by temperature tuning of the laser pump diodes to optimize performance for amplification of pulses with spatial top hat or with spatial Gaussian profiles. The frequently used lumped-line pump model was found inadequate for Tm:Lu2O3. This work reports on the development of a spectral absorption model for a more accurate prediction of pump power deposition and its correlation with the gain uniformity and amplifier output pulse energy.
High-resolution analysis of von Willebrand factor multimeric composition defines a new variant of type I von Willebrand disease with aberrant structure but presence of all size multimers (type IC) (1985)

In Type I von Willebrand disease, the whole series of von Willebrand factor (vWF) multimers is present in plasma, but all are decreased in quantity. No structural abnormality of individual multimers has been demonstrated so far in these patients. We now describe five individuals, from two unrelated families, who had this form of the disease and in whom the complex banding pattern of each vWF multimer was markedly abnormal. Inheritance was autosomal dominant and the clinical expression was mild. A bleeding history was elicited in three of the patients and included recurrent epistaxis, menometrorrhagia, and bleeding following tooth extraction. Replacement therapy had never been required. Although vWF levels in plasma were within the normal range in all of them, the ristocetin cofactor activity was decreased in four, and the bleeding time was prolonged in three. Analysis of vWF multimeric structure by agarose gel electrophoresis, including a newly developed high-resolution technique, demonstrated that the main band of each multimer was present, but a second, well-defined band always seen in normal individuals was missing in the patients. Two additional bands had altered mobility and were less well defined than in normal subjects, and a fifth, less intense band was also undetectable in the patients. Treatment with 1-deamino-8-D-arginine vasopressin (DDAVP) was assessed in two patients. It caused the circulating levels of vWF to increase and correct the bleeding time, but did not alter the structural abnormality. This study describes, therefore, a new variant form of Type I von Willebrand disease with aberrant structure of individual repeating multimers and an associated functional abnormality of vWF. In keeping with previously accepted terminology, the designation of Type IC von Willebrand disease has been adopted for this new variant.
Tunable graphene saturable absorber with cross absorption modulation for mode-locking in fiber laser (2014)

Graphene saturable absorbers (GSAs) have been widely applied in ultra-fast mode-locked fiber lasers. Thanks to the broadband advantage of graphene, we theoretically and experimentally demonstrate the variation of the modulation depth of GSA by employing the effect of cross absorption modulation. This method provides an easy and efficient way to modulate the characteristics of GSA. By varying the modulation power, we realize an all-fiber fundamental mode-locked fiber laser and a harmonic mode-locked fiber laser with tunable output pulse width. Results show that the output pulse widths of the two fiber lasers can be tuned more than 40%, and the lasers have high wide application potential on nonlinear optical bio-imaging and offer an advantageous front end for extreme-power laser technologies.
PnTgs1-like expression during reproductive development supports a role for RNA methyltransferases in the aposporous pathway (2014)

Our results indicate that PnTgs1-like (formerly N69) encodes a trimethylguanosine synthase-like protein whose function in mammals and yeast is critical for development, including reproduction. Our findings also suggest a pivotal role for this candidate gene in nucellar cell fate, as its diminished expression is correlated with initiation of the apomictic pathway in plants.
Characterization of germline genomic alterations in familial pancreas cancer. (2017)

4116 Background: Family history of BRCA-related tumors may correlate with response to chemotherapy and overall survival in patients with pancreatic cancer (PC). We retrospectively compared family history of such cancers with clinical outcomes and underlying molecular aberrations. Methods: A retrospective chart review was conducted of 350 metastatic PC patients treated with first line FOLFIRINOX and Gem/Abraxane at MDACC from 1/2010 -1/2016. Family history was defined as 1 st through 3 rd generation relatives with breast, ovarian, or pancreas cancer. Germline DNA was collected and sequenced using a familial cancer panel using an Illumina 2500. Average coverage was 200X. Platypus calls were analyzed for germline mutations. We assessed mutations in BRCA1, BRCA2, PALB2, MMR genes, ATM, and PolE. Results: Average age was 61. 60% of patients were male. We sequenced blood and tissue samples where available. We found at lease one mutation in 47 of 129 patients tested. There were 56 mutations identified among the 47 patients. Of patients with 0-1,2, or 3 or more affected family members we found mutations in 44%, 47%, and 29%, respectively. Patients with 3+ family members affected tended to have mutations in BRCA1 or PolE. Among the subset of patients with possible deleterious mutations, there were trends towards improved survival in pts with BRCA or PALB aberrations (307d vs 271d, p = ns) but worse outcomes in those with MMR gene defects (181d vs 387d, p = .126). Table 1 indicates outcomes based on number of family members with cancer and their associated mutations. Conclusions: Approximately one third of all patients tested had at least one germline mutation in previously described familial pancreas cancer genes. Screening for inherited cancer susceptibility genes may have prognostic value. [Table: see text]
Olivia Shakespear: Letters to W. B. Yeats (1997)

The thirty-seven letters printed below seem to be all that survive from Olivia Shakespear's side of a correspondence spanning the years 1894 to 1938. Allan Wade printed 121 letters from Yeats to Olivia Shakespear: only about ten further letters to her survive, and most of these are very short. Wade was, however, forced to make significant cuts in some of the letters he did print. Commenting on the letters which did not survive, he remarked: "After Mrs Shakespear's death in October 1938, her son-in-law, Ezra Pound, sent back to Yeats all the letters from him which she had kept, and these unfortunately reached him while he was staying away from home, and some of them he destroyed, apparently at random" (L 12).KeywordsNational GalleryBlack MagicIndian ReligionRegular CorrespondenceCherry OrchardThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Efficient histogram generation using scattering on GPUs (2007)

We present an efficient algorithm to compute image histograms entirely on the GPU. Unlike previous implementations that use a gather approach, we take advantage of scattering data through the vertex shader and of high-precision blending available on modern GPUs. This results in fewer operations executed per pixel and speeds up the computation.
The influence of nano-oxide layer on magnetostriction of sensing layer in bottom spin valves (2006)

The magnetostriction coefficient (λs) of ultrathin sputtered polycrystalline as-deposited and annealed Ta∕Ni81Fe19(t)∕Ta films was studied as a function of the thickness. λs and magnetoresistance (MR) of bottom-type spin valves (SVs) with nano-oxide layer (NOL) added in the pinned layer were investigated by using NiFe, Co90Fe10, and CoFe∕NiFe∕CoFe layers as free layer (FL), respectively. λs of SV with NOL increased slightly except that of CoFe FL. NOLs were added at different positions to study the effects of NOL on λs of CoFe FL. All λs of CoFe FL change from negative to positive and its absolute value also increases significantly with CoFeOx related NOL added below. Our λs and surface roughness results indicated that the structure of the film not the roughness dominates λs of ultrathin FL in SVs.
Affinity change of the adipocyte receptor fails to alter insulin-stimulated glucose transport (1982)

Occupancy increased the affinity of the insulin receptor of the adipocyte. During the affinity change the half-maximal sensitivity of glucose transport to insulin stimulation was unaltered. Decreased maximum response of transport only occurred after the affinity change. There was not a simple relationship between receptor affinity and insulin stimulation of glucose transport in the adipocyte.