gebhart/patrepeval huggingface dataset:
Synthesis of the natural isomer of a tetrahomoterpene alcohol obtained from the codling moth (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleSynthesis of the natural isomer of a tetrahomoterpene alcohol obtained from the codling mothStephen B. Bowlus and John A. KatzenellenbogenCite this: J. Org. Chem. 1973, 38, 15, 2733–2734Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://pubs.acs.org/doi/10.1021/jo00955a042https://doi.org/10.1021/jo00955a042research-articleACS PublicationsRequest reuse permissionsArticle Views75Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Technologic developments in radiotherapy and stereotactic radiosurgery]. (2001)

We present a review of current technological progress enabling improvement in the quality of stereotactic irradiations: imaging fusion; individual adaptation of dosimetric planning to the shape of the target thanks to several collimation systems, spatial modulation of the beam with the use of multileaf microcollimators, beam intensity modulation, robotisation of the materials, owing to hardware and software developments.
Zusammenhänge psychosozialer Faktoren mit saisonalen und perennialen Allergieformen bei Erwachsenen – Querschnittsergebnisse der KORA FF4 Studie (2018)

Die Assoziation psychosozialer Faktoren mit saisonalen und perennialen Allergien wurde noch nicht untersucht. Ziel der Studie war die Analyse der Zusammenhänge von sozialer Schicht, Depression, generalisierter Angst, psychosozialem Stress und Typ-D Persönlichkeit mit saisonalen und perennialen Allergieformen bei Erwachsenen.
Drive-train configurations for Floating wind turbines (2013)

Designing an offshore floating wind turbine brings new structural and mechanical constraints to the nacelle and its components. For the purpose of stability and avoiding critical eigen frequencies for the tower, the tower top mass must not be too high. Because of the transient nature of loads acting at the nacelle and high probability of mechanical failure, the strength and the life of components are at stake. This implies that the components at the nacelle must have a simple design with fewer parts, be lightweight as practically possible and also strong enough to cope with the load dynamics. A survey on some of the floating wind turbine concepts shows that geared driven power trains are the standard design choice. This article identifies some key attributes that are essential for drive-trains to be successfully integrated onto floating wind turbines. An Overview of technology options is presented with a comparative assessment on their suitability to floating wind turbines based on their simplicity, structural integrity and potential for weight reductions. With a number of methods available for weight optimized construction and greater flexibility in design, direct-drive generators appear to be a promising option for floating wind turbines.
Searching for New Cures for Tuberculosis: Design, Synthesis, and Biological Evaluation of 2-Methylbenzothiazoles (2009)

The actual development and clinical use of new therapeutics for tuberculosis (TB) have remained stagnant for years because of the complexity of the disease process, the treatment of which at present requires the administration of drug combinations over a 6 month period. There is thus an urgent need for the discovery and development of novel, more active, and less toxic anti-TB agents. In this study, we report on the chemistry and biology of a series of potent 5-(2-methylbenzothiazol-5-yloxymethyl)isoxazole-3-carboxamide derivatives, which proved to be active against replicating Mycobacterium tuberculosis (Mtb) H(37)Rv. The most potent compounds 7j and 7s were found to inhibit Mtb growth at micromolar concentrations, with MIC values of 1.4 and 1.9 microM, respectively. Impressively, all active compounds were nontoxic toward Vero cells (IC(50) > 128 microM). Moreover, the best of these compounds were also tested against protozoan parasites, and some of these compounds were found to show activity, especially against Plasmodium falciparum. These studies thus suggest that certain 2-methylbenzothiazole based compounds may serve as promising lead scaffolds for further elaboration as anti-TB drugs and as possible antimalaria drugs.
Random phase encoding for optical security (1996)

A new optical encoding method for security applications is proposed. The encoded image (encrypted into the security products) is merely a random phase image statistically and randomly generated by a random number generator using a computer, which contains no information from the reference pattern (stored for verification) or the frequency plane filter (a phase‐only function for decoding). The phase function in the frequency plane is obtained using a modified phase retrieval algorithm. The proposed method uses two phase‐only functions (images) at both the input and frequency planes of the optical processor leading to maximum optical efficiency. Computer simulation shows that the proposed method is robust for optical security applications.
彩色扫描仪 HP ScanJet 4p:价廉物美的平板式彩色扫描仪 (1996)

两年前的今天,一台单通路、300dpi分辨率以下、标准尺寸以下的24位彩色扫描仪需要数千美元,它们主要面向图形专业人员。如今,Hewlett-Packard的HP ScanJet 4p具有同样的性能,而价格只有499美元。 ScanJet 4p具有专业质量水准,但是很显然它是面向家庭和办公室用户的。ScanJet 4p扫描仪用来与价格稍低的送页式个人扫描仪竞争,它尽可能简单地将数字化图象用到了文档中。
“泉城”改装秀——第六届银声杯发烧级汽车音响观赛济南站 (2005)

“银声杯”已举办六届了，带给行业的影响是什么?也许从索兵几年来的参赛历程上可以得到些启示。索兵是山东淄博的一汽车用品经销商，第一次参加银声杯时，还需要在银声公司技术指导下完成作品，且要远赴广州等地才能参赛。刚开始他并没取得什么成绩，但是经过几次赛事的观摩，如今索兵不但可以自行设计参赛作品，而且还成为获奖的大热门。参赛也不像以前那样跋山涉水，现在只要在家门口济南就可以与同行一较高下。
Efficient Query Processing in Arbitrary Subspaces Using Vector Approximations (2006)

In this paper, we introduce the partial vector approximation file, an extension of the well known vector approximation file that is constructed to efficiently answer partial similarity queries in any possible subspace which is not known beforehand. The idea of the partial VA-File is to divide the VA-File into a separate file for each dimension and only load the dimensions that are necessary to answer the query. Thus, the partial VA-File is constructed to improve the query performance for systems that have to cope with a wide variety of previously unknown query subspaces. We propose novel algorithms for partial kNN and å-range queries based on the new partial VA-File. In our experiments, we demonstrate that our proposed partial VA-File with the novel algorithms improves the average query performance in comparison to the original VA-File when answering partial similarity queries.
iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome (2020)

Down syndrome (DS) is a congenital disorder caused by trisomy 21 (T21). It is associated with cognitive impairment, muscle hypotonia, heart defects, and other clinical anomalies. At the same time, individuals with Down syndrome have lower prevalence of solid tumor formation. To gain new insights into aberrant DS development during early stages of mesoderm formation and its possible connection to lower solid tumor prevalence, we developed the first model of two types of DS iPSC-derived stromal cells. Utilizing bioinformatic and functional analyses, we identified over 100 genes with coordinated expression among mesodermal and endothelial cell types. The most significantly down-regulated processes in DS mesodermal progenitors were associated with decreased stromal progenitor performance related to connective tissue organization as well as muscle development and functionality. The differentially expressed genes included cytoskeleton-related genes (actin and myosin), ECM genes (Collagens, Galectin-1, Fibronectin, Heparan Sulfate, LOX, FAK1), cell cycle genes (USP16, S1P complexes), and DNA damage repair genes. For DS endothelial cells, our analysis revealed most down-regulated genes associated with cellular response to external stimuli, cell migration, and immune response (inflammation-based). Together with functional assays, these results suggest an impairment in mesodermal development capacity during early stages, which likely translates into connective tissue impairment in DS patients. We further determined that, despite differences in functional processes and characteristics, a significant number of differentially regulated genes involved in tumorigenesis were expressed in a highly coordinated manner across endothelial and mesodermal cells. These findings strongly suggest that microRNAs (miR-24-4, miR-21), cytoskeleton remodeling, response to stimuli, and inflammation can impact resistance to tumorigenesis in DS patients. Furthermore, we also show that endothelial cell functionality is impaired, and when combined with angiogenic inhibition, it can provide another mechanism for decreased solid tumor development. We propose that the same processes, which specify the basis of connective tissue impairment observed in DS patients, potentially impart a resistance to cancer by hindering tumor progression and metastasis. We further establish that cancer-related genes on Chromosome 21 are up-regulated, while genome-wide cancer-related genes are down-regulated. These results suggest that trisomy 21 induces a modified regulation and compensation of many biochemical pathways across the genome. Such downstream interactions may contribute toward promoting tumor resistant mechanisms.
Air-gap structure between integrated LiNbO_3 optical modulators and micromachined Si substrates (2011)

The air-gap structure between integrated LiNbO(3) optical modulators and micromachined Si substrates is reported for high-speed optoelectronic systems. The calculated and experimental results show that the high permittivity of the Si substrate decreases the resonant modulation frequency to 10 GHz LiNbO(3) resonant-type optical modulator chips on the Si substrate. To prevent this substrate effect, an air-gap was formed between the LiNbO(3) modulator and the Si substrate. The ability to fabricate the air-gap structure was demonstrated using low-temperature flip-chip bonding (100 °C) and a Si micromachining process, and its performance was experimentally verified.
Effect of treatment with a full-occlusion biofeedback splint on sleep bruxism and TMD pain: a randomized controlled clinical trial (2020)

Abstract Objectives The purpose of the present study was to analyze treatment outcome with a full-occlusion biofeedback (BFB) splint on sleep bruxism (SB) and TMD pain compared with treatment with an adjusted occlusal splint (AOS). Materials and methods Forty-one patients were randomly allocated to a test (BFB) or a control (AOS) group and monitored over a 3-month period. Output variables were frequency and duration of bruxing events (bursts) and various pain symptoms. Results The BFB group showed a statistically significant reduction in the frequency and duration of bursts and a statistically significant improvement in the patients’ global well-being and the facial muscle pain parameter. After the treatment was stopped, the BFB group showed a statistically significant reduction in the average and maximum duration but no statistically significant change in the frequency of bursts. Conclusions The tested BFB splint is highly effective in reducing SB at the subconscious level, i.e., without waking the patient, and in achieving improvements in global pain perception. The results suggest that the BFB splint also provides a better treatment option for bruxism-related pain than an AOS. However, further research is needed, and specifically studies with a larger patient population displaying higher levels of pain at baseline. Clinical relevance By reducing burst duration and therefore the pathological load on the masticatory apparatus, the BFB splint reduces TMD and bruxism-related symptoms and improves patients’ physical well-being. In the long term, this could prevent damage to the TMJ. This study confirms the effectiveness and safety of this splint. The universal trial number U1111-1239-2450 DRKS-ID registration DRKS00018092
Ebola-GP DNA Prime rAd5-GP Boost: Influence of Prime Frequency and Prime/Boost Time Interval on the Immune Response in Non-human Primates (2021)

Heterologous prime-boost immunization regimens are a common strategy for many vaccines. DNA prime rAd5-GP boost immunization has been demonstrated to protect non-human primates against a lethal challenge of Ebola virus, a pathogen that causes fatal hemorrhagic disease in humans. This protection correlates with antibody responses and is also associated with IFNγ<sup>+</sup> TNFα<sup>+</sup> double positive CD8<sup>+</sup> T-cells. In this study, we compared single DNA vs. multiple DNA prime immunizations, and short vs. long time intervals between the DNA prime and the rAd5 boost to evaluate the impact of these different prime-boost strategies on vaccine-induced humoral and cellular responses in non-human primates. We demonstrated that DNA/rAd5 prime-boost strategies can be tailored to induce either CD4<sup>+</sup> T-cell or CD8<sup>+</sup> T-cell dominant responses while maintaining a high magnitude antibody response. Additionally, a single DNA prime immunization generated a stable memory response that could be boosted by rAd5 3 years later. These results suggest DNA/rAd5 prime-boost provides a flexible platform that can be fine-tuned to generate desirable T-cell memory responses.
A Systematic Review of Medical Treatments for Children With Autism Spectrum Disorders (2011)

Although many children with ASDs are currently treated with medical interventions, strikingly little evidence exists to support benefit for most treatments. Risperidone and aripiprazole have shown benefit for challenging and repetitive behaviors, but associated adverse effects limit their use to patients with severe impairment or risk of injury.
Ocean acoustics in the rapidly changing Arctic ocean (2022)

The Arctic ocean is undergoing rapid climate change, in fact it is the most rapidly warming area of our planet. Underwater sound is a uniquely effective tool for Arctic monitoring, because it can be used under the ice where satellites are blind. The most striking change has been the reduction of summer ice cover, but recent acoustic experiments have started to gather evidence for other changes as well, such as the reduction of ice scattering from the loss of multiyear ice and the formation of subsurface ducted propagation in the Beaufort Sea. The ambient soundscape is also of great interest as human activity increases in the region and as biological activity responds. Due the strategic importance of the Arctic during the cold war, there is a history of experimental work in the area but this short talk will try to show a few recent examples.
Varicella-Zoster Virus Vasculopathy: A Case Report Demonstrating Vasculitis using Black-Blood MRI (2015)

Infections are rare but important causes of stroke. Among these, varicella zoster virus has been known to cause ischemic stroke. During an attack of herpes zoster ophthalmicus, it has been hypothesized that the virus replicates in the trigeminal ganglion and travels via the trigeminal nerve centrally to cause cerebral vasculopathy. Here we present a case of a 69 year-old Caucasian immunocompromised woman who suffered recurrent ischemic infarcts within the same vascular distribution following an episode of zoster ophthalmicus three months prior. An imaging technique termed black-blood magnetic resonance imaging was utilized to aid in the diagnosis of cerebral vasculitis. The case is used to provide a literature review of the pathogenesis, diagnosis, and treatment of cerebral varicella zoster vasculopathy. In situations where an isolated unilateral cerebral vasculopathy is identified, neurologists are urged to consider varicella zoster as a treatable etiologic agent, as untreated vasculopathy can lead to further strokes.
Thermal and structural characterization of nanofibers of poly(vinyl alcohol) produced by electrospinning (2009)

Abstract Poly(vinyl alcohol) (PVOH) was obtained from the alkaline hydrolysis of poly(vinyl acetate) (PVAc). Nonwoven membranes (mats) of PVOH nanofibers were produced by electrospinning of solutions of PVOH in water with and without aluminum chloride. The concentration of the PVOH/water solution was 12.4% w/v. The morphology of the mats was analyzed by scanning electron microscopy (SEM). The thermal properties and the degree of crystallinity of the nanofibers were measured by differential scanning calorimetry (DSC); the crystal structure of the mats was evaluated by wide‐angle X‐ray diffraction. The best nanofibers were obtained by electrospinning the PVOH/water solution with aluminum chloride (45% w/v) in which an electrical field of 3.0 kV/cm was applied. It was observed that the addition of the aluminum chloride and the increase in the applied electrical field decreased the number‐average nanofibers diameters. The mats without aluminum chloride had higher melting temperatures and higher degrees of crystallinity than the mats with the salt. The crystal structure of the mats was found to be monoclinic; however, the mats were neither highly oriented nor have a high degree of crystallinity. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Stroke during Pregnancy and Puerperium in Young Females below the Age of 40 Years as a Result of Cerebral Venous/Venous Sinus Thrombosis (1980)

One hundred and thirty-eight cases of cerebral venous/venous sinus thrombosis during the puerperium have been studied. Maximum number of cases (112 cases) occurred in the age below 30 years. Signs and symptoms appeared in most of the cases (72 cases) during the first 7 days of post partum period. One hundred and eleven cases were multipara. Commonest signs and symptoms were fever (85 cases); headache (66 cases), convulsions (64 cases), altered consciousness (57 cases), hemiplegia (60 cases), papilloedema (48 cases), etc. Carotid angiography done in 55 cases revealed block in middle part of superior sagittal sinus in 24, and localised, dilated and tortuous cortical veins in 5. A statistically significant rise in serum triglycerides, phospholipids, free fatty acids, blood platelet count, platelet adhesive index, and fall in blood fibrinolytic activity were found as compared with normals. These factors may be playing a role in the etiology of cerebral venous/venous sinus thrombosis during puerperium.
Source emission tests at the Baltimore demonstration pyrolysis facility. Final report (1978)

TRW was retained by EPA/IERL Cincinnati in May of 1976 to conduct source emission tests at a solid waste treatment plant in Baltimore, Maryland. The plant is designed to recover low-grade fossil fuel from non-toxic solid waste by the use of a process known as pyrolysis. When plant construction was completed in January, 1975, it was determined that the pollutant control equipment did not meet particulate emission standards. This necessitated a comprehensive test program designed to quantify the extent of the pollution and evaluate the environmental impact of this plant. The test program was designed to measure the following flue gas parameters; particulate; SO2/SO3;NO(x);HCl:HF; total hydrocarbons; hydrocarbon compounds exceeding 1% of the total hydrocarbon value, but not more than 20; and trace metals. Atmospheric diffusion models were employed to assess the environmental impact of both the existing plant configuration and the proposed pollution control system. The proposed system consists of an electro-static precipitator exhausting to a 220 ft stack. Results of this analysis indicate that the proposed pollution control system represents a considerable improvement over the existing system, particularly in the sense that it should completely eliminate the downwash problem.
Isolation and Identification of Polymethoxyflavones from the Hybrid Citrus, Hallabong (2010)

Seven polymethoxyflavones (PMFs) were isolated from the dried peels of hallabong, the hybrid Citrus , by a repeated column chromatography. The structures of PMFs were identified as 5,6,7,3',4'-pentamethoxyflavone (1), 6,7,8,3',4'-pentamethoxyflavone (2), 3-hydroxy-5,6,7,4'-tetramethoxyflavone (3), 5,6,7,8,3',4'-hexamethoxyflavone (4), 3,6,7,4'-tetramethoxyflavone (5), 3,5,6,7,8,3',4'-heptamethoxyflavone (6), and 5,6,7,8,4'-pentamethoxyflavone (7) using 1H and 13C NMR in combination with mass spectrometry. Among these compounds, 5 was isolated for the first time from nature. The content of PMFs 1-7 in hallabong was determined by HPLC-UV. The major PMFs of hallabong are 5 in the dried peels (15.4 mg/g) and 7 in the dried leaves (12.2 mg/g).
Controlling the photon indistinguishability in single semiconductor quantum dots under resonant excitation (2014)

Communication orale
In Vitro Targeting of Synthesized Antibody-Conjugated Dendrimer Nanoparticles (2004)

This study reports the synthesis and in vitro biological properties of dendrimer-antibody conjugates. The polyamidoamine dendrimer platform was conjugated to fluorescein isothiocyanate as a means to analyze cell binding and internalization. Two different antibodies, 60bca and J591, which bind to CD14 and prostate-specific membrane antigen (PSMA), respectively, were used as model targeting molecules. The binding of the antibody-conjugated dendrimers to antigen-expressing cells was evaluated by flow cytometry, confocal microscopy, and a new two-photon-based optical fiber fluorescence detection system. The conjugates specifically bound to the antigen-expressing cells in a time- and dose-dependent fashion, with affinity similar to that of the free antibody. Confocal microscopic analysis suggested at least some cellular internalization of the dendrimer conjugate. Dendrimer-antibody conjugates are a suitable platform for targeted molecule delivery into antigen-expressing cells.
Magnetic resonance measurement of flowing coal (1983)

Electron and nuclear magnetic resonance were used to determine moisture content, calorific value and proximate and ultimate analyses (except ash) for a number of coals. Application of these techniques to continuous on-line measurement was considered as far as the design of a meter.
An algorithm for detecting contention-based covert timing channels on shared hardware (2014)

As we increasingly rely on computers to process and manage our personal data, safeguarding sensitive information from malicious hackers is a fast growing concern. Among many forms of information leakage, covert timing channels operate by establishing an illegitimate communication channel between two processes and transmitting information via timing modulation, violating the underlying system's security policy. Recent studies have shown the vulnerability of popular computing environments, such as cloud, to these covert timing channels. In this work, we propose an algorithm to detect the possible presence of covert timing channels on shared hardware that use contention-based patterns for communication. Preliminary experiments demonstrate that our algorithm is able to successfully detect different types of covert timing channels at varying bandwidths, message patterns, and has zero false alarms.