gebhart/patrepeval huggingface dataset:
CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease (2007)

The ileal mucosa of Crohn disease (CD) patients is abnormally colonized by adherent-invasive E. coli (AIEC) that are able to adhere to and invade intestinal epithelial cells. Here, we show that CD-associated AIEC strains adhere to the brush border of primary ileal enterocytes isolated from CD patients but not controls without inflammatory bowel disease. AIEC adhesion is dependent on type 1 pili expression on the bacterial surface and on carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) expression on the apical surface of ileal epithelial cells. We report also that CEACAM6 acts as a receptor for AIEC adhesion and is abnormally expressed by ileal epithelial cells in CD patients. In addition, our in vitro studies show that there is increased CEACAM6 expression in cultured intestinal epithelial cells after IFN-gamma or TNF-alpha stimulation and after infection with AIEC bacteria, indicating that AIEC can promote its own colonization in CD patients.
Prognostic and Health Management for Suspended Time-Series (2016)

Prognostic systems are expected to provide predictive information about the Remaining Useful Life (RUL) for equipment and components. During the last ten years, numerous RUL prediction models have been developed. These methods usually treat completed time-series only, i.e. full statistics before the item fails. Under actual operating conditions occasionally number of failed items is too small, and therefore application of uncompleted (suspended) time-series is necessary, and using Semi-Supervised methods instead of Supervised is required. In this paper, we propose an approach based on regression and classification models we have introduced in the past. These models consider monitoring data (time-series) as inputs and RUL estimation as output. Significant difference of this model is using suspended time-series to estimate optimal RUL for each suspended time-series, so they can be used for initial model training. This article describes the procedures that have been developed and applied successfully for Suspended Time-Series using. Several models based on modification of the SVR and SVC methods (Support Vector Regression and Support Vector Classification) are proposed for consideration. Number of uncompleted time-series used for training and cross-validation is proposed as additional control parameter. Suggested methodology and algorithms were verified on the NASA Aircraft Engine database. Numerical examples based on this database have been also considered. Experimental result shows that the proposed model performs significantly better estimations than pure supervised learning based model.
A Universal Biomolecular Concentrator To Enhance Biomolecular Surface Binding Based on Acoustic NEMS Resonator (2018)

In designing bioassay systems for low-abundance biomolecule detection, most research focuses on improving transduction mechanisms while ignoring the intrinsically fundamental limitations in solution: mass transfer and binding affinity. We demonstrate enhanced biomolecular surface binding using an acoustic nano-electromechanical system (NEMS) resonator, as an on-chip biomolecular concentrator which breaks both mass transfer and binding affinity limitations. As a result, a concentration factor of 10<sup>5</sup> has been obtained for various biomolecules. The resultantly enhanced surface binding between probes on the absorption surface and analytes in solution enables us to lower the limit of detection for representative proteins. We also integrated the biomolecular concentrator into an optoelectronic bioassay platform to demonstrate delivery of proteins from buffer/serum to the absorption surface. Since the manufacture of the resonator is CMOS-compatible, we expect it to be readily applied to further analysis of biomolecular interactions in molecular diagnostics.
Low Frequency Radio Research at Thule, Greenland. (1998)

Abstract : The research reported here started in 1993 following Stanford University's submission of a basic research proposal in response to a February 1992 Broad Agency Announcement (BAA) issued by the Phillips Laboratory at Hanscom Air Force Base. The proposed research involved the upgrade of an ELFIVLF/LF radiometer constructed previously by Stanford University for Phillips Laboratory and located at Thule, Greenland, which is essentially at the center of the northern polar cap and which is therefore a unique location for the measurement of ELF/VLF/LF radio signals and noise (frequencies in the range 10 Hz --60kHz). It was proposed that the system would be upgraded by the addition of a new computer with a Stanford-installed digital signal processing capability that would allow the amplitudes and frequency spectra of incoming low-frequency radio signals to be examined in real time either by experimenters on location at Thule or, with slightly less capability, at remote locations via telephone line. We report here the installation of the new computer with its new digital signal processing capability on a system essentially identical to the Thule system but located on the Stanford campus in California, where it was used for measurements during the first transmissions from HAARP, as well as transmissions from HIPAS, during early 1997.
Infrared Reflection-Absorption Spectra of Calcium Icosanate Langmuir-Blodgett Films Observed by Using Zinc Oxide-Based Transparent Electrode and Gold (2010)

As a method for characterizing the electronic state and molecular orientation of organic materials put on electrodes, infrared reflection-absorption spectroscopy (IR-RAS) is a well-known powerful tool. We have demonstrated that transparent electrodes based on zinc oxide are useful as substrates for the IR-RAS measurements. Although their absorption-signal enhancement effect is smaller than that of gold substrates, sometimes IR-RAS with them provides a better basis than that with gold for discussing the molecular orientation.
Akhmediev breather evolution in optical fiber for realistic initial conditions (2011)

Get PDF Email Share Share with Facebook Share on X Post on reddit Share with LinkedIn Add to Mendeley Add to BibSonomy Share with WeChat Get Citation Copy Citation Text M. Erkintalo, G. Genty, B. Wetzel, and J. M. Dudley, "Akhmediev breather evolution in optical fiber for realistic initial conditions," in Nonlinear Optics, OSA Technical Digest (CD) (Optica Publishing Group, 2011), paper NTuC6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Green resource allocation and EE-balancing in multiuser two-way amplify-and-forward relay networks (2017)

In this paper, we investigate an energy-efficient joint subcarrier and power allocation algorithm for improving the worst energy efficiency (worst-EE) in multiuser two-way amplify-and-forward (AF) relay networks, that not only balances the EE of the two-way links, but also ensures the desired quality-of-service (QoS) of each user. In order to maximize the worst-EE, an EE-balancing optimization problem is formulated as the ratio of the spectral efficiency (SE) over the total network power consumption subject to a total transmit power and users' QoS constraints. Since the formulated primal problem is a non-convex fractional mixed binary-integer program, i.e., NP-hard to solve, thus a concave lower bound on the objective function and a series of convex transformations are applied to transform the problem into a tractable convex form. An iterative algorithm is proposed to achieve the optimal solution of the dual problem. We further propose an efficient, low-complexity suboptimal resource allocation algorithm. Simulation results demonstrate the effectiveness of the proposed iterative and suboptimal algorithms.
Identification and survival outcomes of a cohort of patients with cancer of unknown primary in Ontario, Canada (2015)

CUP patients in Ontario have a poor prognosis. Some subgroups may have better survival rates, such as patients with metastases localised to lymph nodes and patients with squamous cell histology.
Messung des Reibbeiwertes von gehäckselten Materialien (2014)

Feldhäcksler erreichen immer größere Leistungen und Durchsätze. Aufgrund der Art des Materialtransportes haben diese Maschinen sehr hohe Reibungsverluste. Um diese Verluste zu reduzieren, muss der Gutfluss im Feldhäcksler analysiert werden. Dazu müssen zunächst die Reibbeiwerte von gehäckseltem Gras und Mais bestimmt werden. Zur genauen Messung der Reibbeiwerte wurde ein Versuchsstand gebaut, mit dem bei unterschiedlichen Einstellungen verschiedene Versuche durchgeführt werden können.
Optical coherence tomography: technology and applications (2003)

Optical coherence tomography (OCT) is an emerging biomedical imaging modality which can generate high resolution, cross-sectional images of microstructure in biological systems. OCT is analogous to ultrasound B mode imaging, except that it uses light instead of sound. Because the velocity of light is extremely high, direct electronic detection is not possible and imaging is performed using low coherence interferometry. Echoes of light from the specimen or tissue are correlated or interfered with light that travels a known reference path length. OCT images are generated by measuring the echo time delay of optical backscattering in the tissue as a function of transverse position and the data can be displayed as a false color or grey scale image. The axial resolution is determined by the coherence length of the light source. Imaging resolutions of 1 to 15 /spl mu/m can be achieved.
Prospective Study of the Performance of Vibrational Spectroscopies for Rapid Identification of Bacterial and Fungal Pathogens Recovered from Blood Cultures (2003)

Rapid identification of microbial pathogens reduces infection-related morbidity and mortality of hospitalized patients. Raman spectra and Fourier transform infrared (IR) spectra constitute highly specific spectroscopic fingerprints of microorganisms by which they can be identified. Little biomass is required, so that spectra of microcolonies can be obtained. A prospective clinical study was carried out in which the causative pathogens of bloodstream infections in hospitalized patients were identified. Reference libraries of Raman and IR spectra of bacterial and yeast pathogens highly prevalent in bloodstream infections were created. They were used to develop identification models based on linear discriminant analysis and artificial neural networks. These models were tested by carrying out vibrational spectroscopic identification in parallel with routine diagnostic phenotypic identification. Whereas routine identification has a typical turnaround time of 1 to 2 days, Raman and IR spectra of microcolonies were collected 6 to 8 h after microbial growth was detected by an automated blood culture system. One hundred fifteen samples were analyzed by Raman spectroscopy, of which 109 contained bacteria and 6 contained yeasts. One hundred twenty-one samples were analyzed by IR spectroscopy. Of these, 114 yielded bacteria and 7 were positive for yeasts. High identification accuracy was achieved in both the Raman (92.2%, 106 of 115) and IR (98.3%, 119 of 121) studies. Vibrational spectroscopic techniques enable simple, rapid, and accurate microbial identification. These advantages can be easily transferred to other applications in diagnostic microbiology, e.g., to accelerate identification of fastidious microorganisms.
Optical add/drop multiplexer for dynamic channelrouting (1999)

The system performance of an add/drop module based on piezoelectrically wavelength tunable fibre Bragg gratings is investigated. The power penalties at 10 Gbit/s in transmission and reflection mode are measured at the drop and park position of the gratings.
Functional Bio-inorganic Hybrids from Silicon Quantum Dots and Biological Molecules (2020)

Quantum dots (QDs) are semiconductor nanoparticles that exhibit photoluminescent properties useful for applications in the field of diagnostics and medicine. Successful implementation of these QDs for bio-imaging and bio/chemical sensing typically involves conjugation to biologically active molecules for recognition and signal generation. Unfortunately, traditional and widely studied QDs are based upon heavy metals and other toxic elements (<i>e.g.</i>, Cd- and Pb-based QDs), which precludes their safe use in actual biological systems. Silicon quantum dots (SiQDs) offer the same advantages as these heavy-metal-based QDs with the added benefits of nontoxicity and abundance. The preparation of functional bio-inorganic hybrids from SiQDs and biomolecules has lagged significantly compared to their traditional toxic counterparts because of the challenges associated with the synthesis of water-soluble SiQDs and their relative instability in aqueous environments. Advances in SiQD synthesis and surface functionalization, however, have made possible the preparation of functional bio-inorganic hybrids from SiQDs and biological molecules through different bioconjugation reactions. In this contribution, we review the various bioconjugate reactions by which SiQDs have been linked to biomolecules and implemented as platforms for bio-imaging and bio/chemical sensing. We also highlight the challenges that need to be addressed and overcome for these materials to reach their full potential. Lastly, we give prospective applications where this unique class of nontoxic and biocompatible materials can be of great utility in the future.
From night bustle to printed quietness (2001)

For the scientist, the theme of this issue, Science communication, has two aspects: communication of his results to other scientists and communication of the general trends of science to the general public.In this assay, I will address the first aspect only.For a researcher, it is not enough to do experiments, obtain facts, use them to form a theory.He must also make these results known.Convince his colleagues of the importance of his work, of the value of his theory.In short, he must seize every opportunity to advertise, to peddle his wares.Expose
Applications of integrated solar cells in low noise instrumentation (2013)

Small sized solar cells in compact SOIC packages are investigated as candidates for the design of floating low noise voltage reference to be used in low noise applications. The noise introduced by the solar cell as a function of the incident light is investigated and a simplified model is extracted that can be used, together with a proper filtering stage and a closed loop control system, for the implementation of very low noise, high accuracy programmable voltage and current sources. In proper conditions and down to a few hundreds mHz, the residual low frequency noise of such sources can be reduced down to the noise introduced by the very low noise JFET devices employed for the realization of the output buffer (voltage sources) or of the voltage to current converter (current sources).
New perspectives in oral peptide delivery (2021)

Owing to their structural diversity, peptides are a unique source of innovative active ingredients. However, their development has been challenging because of their disadvantageous pharmacokinetic (PK) properties. Over the past decade, many attempts have been made to improve the oral bioavailability of peptide drugs. In this review, we highlight the most recent and promising techniques aimed at the improvement of the oral bioavailability of peptides. The most recent findings will influence future approaches of pharmaceutical companies in the development of new, more efficient, and safer orally delivered peptides.
Modeling of electronic density of states for single-wall carbon and boron nitride nanotubes (2003)

The electronic density of states is calculated for all possible geometric configurations of single-wall carbon and boron nitride nanotubes. The calculation is based on the numerical differentiation of the two-dimensional dispersion relations for graphite and hexagonal boron nitride. The differentiation is performed for all allowed values of the wave vector using the π-electron approximation. For the particular carbon nanotubes chosen as examples, a good agreement is demonstrated between the calculated values of energy spacing of the symmetric van Hove singularities in the density of states and the experimental data obtained from the resonance Raman scattering study.
General discussion (1961)

B. R. Sundheim, W. Fischer, A. Klemm, R. W. Laity, J. O'M. Bockris, M. Shimoji, J. D. Corbett, M. A. Bredig, H. J. V. Tyrrell, P. W. M. Jacobs, A. Lundén, A. R. Ubbelohde, E. Rhodes, J. W. Tomlinson, C. A. Angell and G. J. Hills, Discuss. Faraday Soc., 1961, 32, 250 DOI: 10.1039/DF9613200250
A simple derivation of the coding theorem and some applications (1965)

Upper bounds are derived on the probability of error that can be achieved by using block codes on general time-discrete memoryless channels. Both amplitude-discrete and amplitude-continuous channels are treated, both with and without input constraints. The major advantages of the present approach are the simplicity of the derivations and the relative simplicity of the results; on the other hand, the exponential behavior of the bounds with block length is the best known for all transmission rates between <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</tex> and capacity. The results are applied to a number of special channels, including the binary symmetric channel and the additive Gaussian noise channel.
Supplementary Figure 4 from Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases (2023)

&lt;p&gt;Knockdown of Mad2 or BubR1 in TNBC cells treated with KW-2450.&lt;/p&gt;
A literature mining-based approach for identification of cellular pathways associated with chemoresistance in cancer (2015)

Chemoresistance is a major obstacle to the successful treatment of many human cancer types. Increasing evidence has revealed that chemoresistance involves many genes and multiple complex biological mechanisms including cancer stem cells, drug efflux mechanism, autophagy and epithelial-mesenchymal transition. Many studies have been conducted to investigate the possible molecular mechanisms of chemoresistance. However, understanding of the biological mechanisms in chemoresistance still remains limited. We surveyed the literature on chemoresistance-related genes and pathways of multiple cancer types. We then used a curated pathway database to investigate significant chemoresistance-related biological pathways. In addition, to investigate the importance of chemoresistance-related markers in protein-protein interaction networks identified using the curated database, we used a gene-ranking algorithm designed based on a graph-based scoring function in our previous study. Our comprehensive survey and analysis provide a systems biology-based overview of the underlying mechanisms of chemoresistance.
Toll-Like Receptor 5-Deficient Mice Have Dysregulated Intestinal Gene Expression and Nonspecific Resistance to Salmonella -Induced Typhoid-Like Disease (2008)

The recognition of flagellin by Toll-like receptor 5 (TLR5) is the dominant means by which model intestinal epithelia activate proinflammatory gene expression in response to Salmonella enterica. The role of the flagellin-TLR5 interaction in vivo has been addressed primarily via studies that use flagellar mutants. Such studies suggest that host recognition of flagellin promotes rapid neutrophil recruitment that protects the host from this pathogen. However, these works do not directly address the role of TLR5 and are subject to the caveat that flagellar mutations may broadly affect Salmonella gene expression. Thus, we examined the role of the flagellin-TLR5 interaction via the use of TLR5-deficient (TLR5KO) mice. We utilized both the traditional model of murine Salmonella infection, wherein low-dose oral infection of mice with Salmonella enterica subsp. enterica serovar Typhimurium results in systemic typhoid-like disease, and a more recently characterized model in which mice are pretreated with streptomycin to result in gut-restricted acute enteritis. In the enteritis model, TLR5KO mice had more severe gut pathology, thus "phenocopying" previous results obtained with Salmonella mutants. In contrast, TLR5KO mice were resistant to Salmonella-induced typhoid-like disease. However, such resistance was not specific for flagellated serovar Typhimurium, but rather, TLR5KO mice were also resistant to challenges by flagellin-deficient serovar Typhimurium. Such resistance associated with elevations in the microbiota was ablated by antibiotic pretreatment and correlated with basal elevations in intestinal host defense gene expression. All together, these results indicate that the resistance of TLR5KO mice to Salmonella-induced typhoid-like illness resulted from alterations in their basal phenotype rather than from the lack of TLR5 ligation during the infection per se.
PLASMA CATECHOLAMINES AND ADRENOCEPTORS AFTER CHRONIC SINOAORTIC DENERVATION IN DOGS (1989)

Chronic sinoaortic denervation (SAD) performed by section of both carotid and aortic nerves induced a significant and sustained increase in blood pressure and heart rate in conscious dogs; under our experimental conditions, the values of systolic blood pressure and heart rate were never lower than 190 mmHg and 120 beats/min, respectively. The present long-term study (8 mo) investigated the time-course of plasma catecholamine levels and circulating blood cell adrenoceptor (leukocyte beta 2 and platelet alpha 2) number. Catecholamine plasma levels were highly correlated with the variations of leukocyte beta adrenoceptors (measured by [125I]cyanopindolol binding and characterized as a beta 2 receptor in dogs). These two parameters followed a biphasic pattern after SAD: during the first 2 mo, significant increases in noradrenaline and adrenaline levels were associated with a decrease in leukocyte beta 2 adrenoceptor number; from the 4th month, they slowly returned to normal values, although blood pressure remained elevated. By contrast, platelet alpha 2 adrenoceptor number (measured by [3H]yohimbine binding) did not follow this pattern since it remained lower than before SAD during the whole experiment. Finally, the development (but not the maintenance) of SAD-induced hypertension is associated with an increase in sympathetic tone. Only leukocyte beta 2 (and not platelet alpha 2) adrenoceptors are directly regulated by the endogenous levels of catecholamines.
Supplementary Data from Design of Folate-Linked Liposomal Doxorubicin to its Antitumor Effect in Mice (2023)

Supplementary Data from Design of Folate-Linked Liposomal Doxorubicin to its Antitumor Effect in Mice
Isolated Impairment of Memory Following a Penetrating Lesion of the Fornix Cerebri (1985)

Persistent memory problems were reported by a 39-year-old man who suffered a penetrating brain wound while serving in Vietnam 15 years earlier. Neuropsychological testing indicated an unusually isolated memory impairment. Computed tomography revealed transection of the columns of the fornix cerebri with no temporal-lobe involvement and minimal thalamic damage. We suggest that the fornix cerebri has a role in the maintenance of information accessibility to both encoding and recall during post-working memory processing and in the organization of verbal information during encoding and/or retrieval for declarative (recall) purposes. These processes are not essential for verbal recognition but can result in decrements on specific laboratory tasks and in social adjustment.