gebhart/patrepeval huggingface dataset:
Conventions for the use of the Session Description Protocol (SDP) for ATM Bearer Connections (2001)

Status of this Memo This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the &amp;quot;Internet Official Protocol Standards &amp;quot; (STD 1) for the standardization state and status of this protocol. Distribution of this memo is unlimited. Copyright Notice
Efficacy of an individualized, motivationally-tailored physical activity intervention (1998)

This study compared the efficacy of two low-cost interventions for physical activity adoption. Sedentary (N = 194) adults recruited through newspaper advertisements were randomized to receive either a motivationally-matched, individually-tailored intervention (IT) or a standard self-help intervention (ST). Assessments and interventions were delivered by repeated mailings at baseline, one, three, and six months. Participants were assessed regarding current physical activity behavior, motivational readiness to adopt regular physical activity, and psychological constructs associated with physical activity participation (e.g. self-efficacy, decisional balance). Repeated measures analyses of variance (ANOVAs) revealed significant increases in physical activity participation between baseline and six months for both groups with a significantly greater increase among IT participants. The IT group outperformed the ST group on all primary outcome measures: (a) minutes of physical activity per week, (b) reaching Centers for Disease Control and American College of Sports Medicine (CDC/ACSM) recommended minimum physical activity criteria, and (c) achieving the Action stage of motivational readiness for physical activity adoption. Both groups showed significant improvement between baseline and six months on the psychological constructs associated with physical activity adoption (e.g. self-efficacy), with no significant differences observed between the treatment groups. Utilizing computer expert systems and self-help manuals to provide individually-tailored, motivationally-matched interventions appears to be an effective, low-cost approach for enhancing physical activity participation in the community.
The Mechanism of the Oxidative Dissolution of Colloidal Gold in Cyanide Media (1998)

The kinetics of the dissolution of colloidal gold in aerated cyanide solutions has been investigated with a view to developing a fundamental understanding of the mechanism involved. Experimental results obtained are consistent with an electrochemical mixed potential model, where the mixed potential is set up in the passive or passive interpeak region of the anodic polarization curve, giving rise to a rate of dissolution which is controlled by the rate of a surface reaction. Electron microscope studies suggest that the colloidal particles dissolve in a uniform shrinking particle manner. Mass‐transfer coefficients for the transfer of dissolved oxygen to the colloidal surface appear to be very high, with estimates for gelatin stabilized colloids being of the order of 10−4 m/s, and for unstabilized colloids 0.1 m/s. These latter estimates are in agreement with values predicted from a hydrodynamic treatment of the diffusion layer.
Countermeasures in longterm spaceflights. Russian experience (2002)

The system of countermeasures was developed in Russia, that included as primary components: physical methods aimed to maintain the distribution of fluids at levels close to those experienced on Earth; physical exercises and loading suits aimed to load the musculoskeletal and the cardiovascular systems; measures that prevent the loss of fluids, mainly, water-salt additives which aid to maintain orthostatic tolerance and endurance to gravitational overloads during the return to Earth; well-balanced diet and medications directed to correct possible negative reactions of the body to weightlessness. The system tested in flights with more than 80 participants of primary missions who worked on Russian space stations from 16 to 438 days, demonstrated the capability to maintain cosmonauts health and performance during flight and to prevent or significantly reduce the negative consequences of long-duration stays in weightlessness after its conclusion. To control the performance of physical exercises periodic monthly sessions of recording crew performance on the training devices were provided. The effectiveness of the training mode performed by crew members was also assessed according to the parameters of the treadmill test with gradually increasing locomotor loads. Testing the state of the cosmonauts' physiological functions and work capacity level after completion of the flight, opened the opportunity to evaluate the effectiveness of the system when it was utilized fully or in reduced modes, and also when it was used in one or another modification proposed by crew members.
New Nanocomposite Materials with Improved Mechanical Strength and Tailored Coefficient of Thermal Expansion for Electro-Packaging Applications (2017)

In this research, copper nanocomposites reinforced by graphene nanoplatelets (GNPs) were fabricated using a wet mixing method followed by a classical powder metallurgy route. In order to find the best dispersion technique, ball milling and wet mixing were chosen. Qualitative evaluation of the structure of the graphene after mixing indicated that the wet mixing is an appropriate technique to disperse the GNPs. Thereafter, the influence of graphene content on microstructure, density, hardness, elastic modulus, and thermal expansion coefficient of composites was investigated. It was shown that by increasing the graphene content the aggregation of graphene is more obvious and, thus, these agglomerates affect the final properties adversely. In comparison with the unreinforced Cu, Cu–GNP composites were lighter, and their hardness and Young’s modulus were higher as a consequence of graphene addition. According to the microstructural observation of pure copper and its composites after sintering, it was concluded that grain refinement is the main mechanism of strengthening in this research. Apart from the mechanical characteristics, the coefficient of thermal expansion of composites decreased remarkably and the combination of this feature with appropriate mechanical properties can make them a promising candidate for use in electronic packaging applications.
Smad7 Gene Therapy Ameliorates an Autoimmune Crescentic Glomerulonephritis in Mice (2007)

Autoimmune crescentic glomerulonephritis is characterized by severe immune response with glomerular crescentic formation and fibrosis in the kidney. Recent studies indicate that overexpression of renal Smad7 attenuates both renal fibrosis and inflammation in rat remnant kidney. However, little attention has been paid to the potential role of TGF-beta/Smad signaling in autoimmune kidney disease. This study tested the hypothesis that blocking TGF-beta signaling by overexpression of Smad7 may have a therapeutic effect in a mouse model of autoimmune crescentic glomerulonephritis that was induced in C57BL/6 x DBA/2J F1 hybrid mice by giving DBA/2J donor lymphocytes. Smad7 gene was transfected into the kidney using the ultrasound-microbubble-mediated system. Results showed that overexpression of Smad7 blocked both renal fibrosis and inflammatory pathways in terms of Smad2/3 and NF-kappaB activation (P < 0.01), thereby inhibiting alpha-smooth muscle actin; collagen I, III, and IV accumulation; and expression of inflammatory cytokines (IL-1beta and IL-6), adhesion molecule/chemokine (intercellular adhesion molecule-1, monocyte chemoattractant protein-1), and inducible nitric oxide synthase (all P < 0.01). Leukocyte infiltration (CD4(+) cells and macrophages) was also suppressed (P < 0.005). Severe histologic damage (glomerular crescent formation and tubulointerstitial injury) and functional injury including proteinuria were significantly improved (all P < 0.05). This study provides important evidence that overexpression of Smad7 may have therapeutic potential for autoimmune kidney disease.
The sub‐membrane reticulum of the human erythrocyte: A scanning electron microscope study (1977)

A web-like reticulum underlying the human erythrocyte membrane was studied at a resolution of 5-10 nm by means of scanning electron microscope. The network was visualized in isolated membranes (ghosts) torn open to reveal their interior space and in residues derived from ghosts extracted with Triton X-100. It formed a continuous (rather than patchy) cover over the entire cytoplasmic surface, except where lifted off or torn away. Filaments (5-40 nm in diameter), annular figures (40-60 nm in diameter), and nodes (30-100 nm in diameter) were prominent in different networks. The dimensions of the filaments and the interstices in the reticulum varied with conditions, suggesting that the network has elastic properties. This reticulum is probably related to the erythrocyte membrane proteins spectrin and actin.
Genome sequence and description of the anaerobic lignin-degrading bacterium Tolumonas lignolytica sp. nov. (2015)

Tolumonas lignolytica BRL6-1(T) sp. nov. is the type strain of T. lignolytica sp. nov., a proposed novel species of the Tolumonas genus. This strain was isolated from tropical rainforest soils based on its ability to utilize lignin as a sole carbon source. Cells of Tolumonas lignolytica BRL6-1(T) are mesophilic, non-spore forming, Gram-negative rods that are oxidase and catalase negative. The genome for this isolate was sequenced and returned in seven unique contigs totaling 3.6Mbp, enabling the characterization of several putative pathways for lignin breakdown. Particularly, we found an extracellular peroxidase involved in lignin depolymerization, as well as several enzymes involved in β-aryl ether bond cleavage, which is the most abundant linkage between lignin monomers. We also found genes for enzymes involved in ferulic acid metabolism, which is a common product of lignin breakdown. By characterizing pathways and enzymes employed in the bacterial breakdown of lignin in anaerobic environments, this work should assist in the efficient engineering of biofuel production from lignocellulosic material.
Target synthesis of a novel porous aromatic framework and its highly selective separation of CO2/CH4 (2013)

A novel porous aromatic framework based on tetra-(4-anilyl)-methane and cyanuric chloride has been designed and synthesized successfully, which possesses permanent porosity and high selectivity of CO2 towards CH4.
TRIM28 congenital predisposition to Wilms’ tumor: novel mutations and presentation in a sibling pair (2020)

Wilms' tumor is the most common renal malignancy in children. In addition to staging, molecular risk stratification, such as loss of heterozygosity (LOH) in Chromosomes 1 and 16, is being increasingly used. Although genetic predisposition syndromes have been well-characterized in some Wilms' tumors, recent sequencing and biology efforts are expanding the classification of this malignancy. Here we present a case of siblings with remarkably similar presentations of bilateral Wilms' tumor at ∼12 mo of age. Thorough exam after the younger sibling was diagnosed did not reveal any signs to suggest one of the known Wilms' predisposition syndromes. Both were treated with standard therapies with good response and long-term sustained complete remission of 53 and 97 mo, respectively. Whole-exome sequencing was performed on a tumor sample from each patient and matched blood from one, revealing a shared truncation mutation of <i>TRIM28</i> in all three samples with heterozygosity in the germline sample. <i>TRIM28</i> loss has been recently implicated in early-stage Wilms' tumors with epithelioid morphology. These siblings expand the phenotype for presentation with multifocal disease with retained excellent response to standard therapy.
Asymptotically efficient, binary-compatible block codes for M-ary runlength-limited constraints (2002)

We present a new result on the capacity of M-ary runlength limited constraints and use it to construct asymptotically efficient block codes. The codes are constructed from permutation codes and are scalable with respect to M. The codes are useful in high-rate constrained coding and nonbinary optical recording systems that achieve both high density and backward compatibility to binary recording.
Low threshold current implanted-planar-buried-heterostructure, graded-index, separate-confinement-heterostructure GaAs-AlGaAs laser (1990)

We report low threshold current, CW operation of an Implanted-Planar-Buried-Heterostructure, GRaded-INdex, Separate-Confinement-Heterostructure laser. Implantation forms the p-n-p-n current-blocking layers and a buried-heterostructure waveguide resulting in high-quality, index-guided laser diodes for photonic circuit applications. 3 figs.
The Influence of Ultraviolet‐B Radiation on Growth, Hydroxycinnamic Acids and Flavonoids ofDeschampsia antarcticaduring Springtime Ozone Depletion in Antarctica¶† (2005)

We examined the influence of solar ultraviolet-B radiation (UV-B; 280-320 nm) on the growth, biomass production and phenylpropanoid concentrations of Deschampsia antarctica during the springtime ozone depletion season at Palmer Station, along the Antarctic Peninsula. Treatments involved placing filters on frames over potted plants that reduced levels of biologically effective UV-B either by 83% (reduced UV-B) or by 12% (near-ambient UV-B) over the 63 day experiment (7 November 1998-8 January 1999) when ozone depletion averaged 17%. Plants growing under near-ambient UV-B had 41% and 40% lower relative growth rates and net assimilation rates, respectively, than those under reduced UV-B. The former plants produced 50% less total biomass as a result of having 47% less aboveground biomass. The reduction in aboveground biomass was a result of a 29% lower leaf elongation rate resulting in shorter leaves and 59% less total leaf area in plants grown under reduced UV-B. p-Coumaric, caffeic and ferulic acids were the major hydroxycinnamic acids, and luteolin derivatives were the major flavonoids in both insoluble and soluble leaf extracts. Concentrations of insoluble p-coumaric and caffeic acid and soluble ferulic acids were 38%, 48% and 60% higher, respectively, under near-ambient UV-B than under reduced UV-B. There were no UV-B effects on concentrations of insoluble or soluble flavonoids.
Absolute rate constants for hydrocarbon oxidation. XI. The reactions of tertiary peroxy radicals (1968)

Rate constants have been measured for the chain-terminating self-reactions of six tertiary peroxy radicals. The rate constants vary from ~ 1 × 10 3 M −1 s −1 for t-butylperoxy to ~ 6 × 10 4 M −1 s −1 for 1,1-diphenylethylperoxy radicals. It is suggested that the variation in the rate constants may be related to differences in the stability of the alkoxy radical products of tetroxide decomposition.Rate constants for hydrogen atom abstraction from aralkanes by tertiary peroxy radicals do not seem to be significantly affected by the structure of the attacking radical.In solution the triphenylmethylperoxy radical probably exists in equilibrium with the triphenylmethyl radical and oxygen. Chain termination in oxidations involving the triphenylmethylperoxy radical as the chain carrier occurs by the reaction of this radical with a triphenylmethyl radical.
Suppression of an unwanted flow of charged particles in a tandem accelerator with vacuum insulation (2016)

In the construction of a tandem accelerator with vacuum insulation several changes were made. This allowed us to suppress the unwanted flow of charged particles in the accelerator, to improve its high-voltage stability, and to increase the proton beam current from 1.6 mA to 5 mA.
Potential central nervous system antitumor agents. Aziridinylbenzoquinones. 2 (1976)

A series of 15 2,5-diaziridinyl-3,6-bis(alkylamino)-1,4-benzoquinone derivatives was synthesized and evaluated as central nervous system antitumor agents in the murine intracerebral L1210 and ependymoblastoma brain tumor systems. Intraperitoneal activity was evaluted in the leukemia L1210, P388, and B16 melanocarcinoma tumor models. The more hydrophilic hydroxyalkylamino compounds were the most effective in the intraperitoneal ascites systems (L1210, P388) with the dihydroxypropylamino (18) and hydroxyethylamino (17) analogues producing long-term survivors. The simple, more lipophilic mono- and dialkylamino derivatives were most effective in the intracerebral systems. Multiple long-term survivors were obtained with the methyl (13), ethyl (14), and dimethylamino (20) compounds in the ependymoblastoma brain tumor system. The parent amino analogue 12 was very active in several tumor models. The relationship between structure, activity, and water solubility are discussed.
LVRT dynamic performance analysis in a detailed time domain simulation scenario beyond the impedance divisor fault (2013)

This paper presents the implementation of the low voltage ride-through (LVRT) voltage curve based on two different grid models. The first grid model is based on an inductive divisor, the classic model used in electromagnetic transient analyses and the second one is based on an equivalent dynamic model of the grid which is usually used in dynamic analyses of power systems. Both grid models and their associated LVRT voltage curves are implemented by using electromagnetic time domain simulation (PSCAD/EMTDC). The LVRT curve is evaluated based on the Spanish REE grid.
The internal bacterial diversity of stored product pests (2015)

Symbiotic bacteria associated with insects play important roles in different physiological processes such as digestion, insect behavior, defense and providing essential nutrition in insect gut. In addition, these bacteria can be used in biocontrol of insect pests using genetic engineering techniques. The first step is to isolate and identify symbiotic bacteria from insects to elucidate their roles, and to use in the development of transgenic strains. For this purpose, we isolated and characterized the bacterial isolates from stored product pests using a combination of conventional tests and 16S rRNA sequence analysis. The bacterial flora of Callosobruchus maculatus included Bacillus pumilus, Staphylococcus sp. and Pantoea sp. Acanthoscelides obtectus flora included Staphylococcus kloosii, Staphylococcus sp., S. saprophyticus and Enterococcus faecalis. The internal flora of Sitotroga cerealella included Staphylococcus succinus, Enterococcus sp. and Staphylococcus sp. Finally, Phthorimaea operculella flora included Bacillus sp., Staphylococcus sciuri, Enterococcus mundtii, E. casseliflavus, Alcaligenes faecalis, Enterobacter sp., Pantoea agglomerans and Pseudomonas fluorescens.
TD-07 Dissecting the role of myeloid cells in lupus nephritis (2018)

<h3>Background</h3> The NIH- sponsored AMP -PEARL (Accelerating Medicine Partnership lupus network Pathway Exploration and Analysis in RenaL disease) consortium sequenced RNA from ∼2900 single cells from lupus nephritis kidney biopsies from 24 patients and discovered 22 immune cell types. While providing unprecedented molecular information, the study lacked <i>in situ</i> immune cell spatial context and was underpowered for associations with clinical outcomes. Thus, we aimed to investigate the spatial organization of the immune landscape in lupus nephritis tissue and determine whether <i>in situ</i> immune cell organization drives clinical outcomes. We hypothesize that the immune cell infiltrate in lupus nephritis tissue is highly organized and promotes kidney remodeling that drives clinical outcomes. <h3>Methods</h3> We assembled a new, larger cohort of 40 lupus nephritis patients who presented with varying disease severity, undergoing their first kidney biopsies (naïve to potent immune-modulators). From these biopsy samples, we are dissecting the organizational landscape, role, and clinical associations of the five newly discovered myeloid subsets in formalin fixed paraffin embedded tissue. To map the <i>in situ</i> spatial relationships, we converted single cell RNA-sequencing signatures into molecular stains based on highly expressed myeloid subset-specific discriminatory genes with known biological functions. We then stained clinical samples from our cohort for multiplex fluorescent imaging of newly identified cell subsets. <h3>Results</h3> We have validated the five new myeloid subsets (three monocytes, one dendritic cell, and one macrophage) in class IV lupus nephritis tissue and we are working to do the same in other histological classes. In addition, we are deconstructing myeloid subset cellular neighborhoods by mapping each to renal compartments, tissue damage, and quantifying the composition of the neighborhood’s immune cell (T, B, NK cells) infiltrate. <h3>Conclusions</h3> By converting single cell RNA sequencing information into molecular stains we have developed a novel approach to validate <i>in situ</i> five newly identified myeloid subsets in class IV lupus nephritis and we are pursuing other histological classes. We are deconstructing the <i>in situ</i> cellular neighborhood by mapping each subset across tissue to determine its relation to histopathological lesions and clinical outcomes. We expect these data to link the new myeloid subsets to distinct cellular neighborhoods, and provide the first-ever connection between well-characterized <i>in situ</i> local immune responses, their histopathologic lesions, and clinical outcomes in our clinically annotated cohort. This work will lay the groundwork for disease re-classification based on the immune response and could highlight important cell-types and pathways driving disease for follow up studies.
Understanding the crucial role of local crystal order in the electrocatalytic activity of crystalline manganese oxide (2018)

<italic>In situ</italic> spectroscopic investigation elucidates the crucial role of local structural order in the excellent electrocatalytic activity of crystalline MnO<sub>2</sub>.
Study of directed self assembly of block copolymer with positive tone resists (2011)

In this work, electron beam lithography (EBL) has been employed to generate sub-50 nm line-width test patterns on positive tone, open source EUV resist and EBL resist on tailored neutral layer on silicon substrates. Diblock copolymers were deposited into patterned resists by spin-coating, and perpendicular lamella orientation of the BCPs was achieved through annealing and dry etching. In addition, we report on the development of low temperature annealing processes for direct self assembly using highly segregating block copolymer, and the freezing of patterned EUV resist used for accommodating the high temperature annealing required for the lamella formation of weaker segregating blocks.