gebhart/patrepeval huggingface dataset:
Interaction of vasculotropin/vascular endothelial cell growth factor with human umbilical vein endothelial cells: Binding, internalization, degradation, and biological effects (1991)

Vasculotropin/vascular endothelial cell growth factor (VAS/VEGF) is a newly purified growth factor with a unique specificity for vascular endothelial cells. We have investigated the interactions of VAS/VEGF with human umbilical vein endothelial cells (HUVE cells). 125I-VAS/VEGF was found to HUVE cells in a saturable manner with a half-maximum binding at 2.8 ng/ml. Scatchard analysis did show two classes of high-affinity binding sites. The first class displayed a dissociation constant of 9 pM with 500 sites/cell. The dissociation constant and the number of binding sites of the second binding class were variable for different HUVE cell cultures (KD = 179 +/- 101 pM, 5,850 +/- 2,950 sites/cell). Half-maximal inhibition of 125I-VAS/VEGF occurred with a threefold excess of unlabeled ligand. Basic fibroblast growth factor (bFGF) and heparin did not compete with 125I-VAS/VEGF binding. In contrast, suramin and protamin sulfate completely displaced 125I-VAS/VEGF binding from HUVE cells. VAS/VEGF was shown to be internalized in HUVE cells. Maximum internalization (55% of total cell-associated radioactivity) was observed after 30 min. 125I-VAS/VEGF was completely degraded 2-3 hr after binding. At 3 hr, the trichloroacetic acid (TCA)-soluble radioactivity accumulated in the medium was 60% of the total radioactivity released by HUVE cells. No degradation fragment of 125I-VAS/VEGF was observed. Chloroquine completely inhibited degradation. VAS/VEGF was able to induce angiogenesis in vitro in HUVE cells. However, it did not significantly modulate urokinase-type plasminogen activator (u-PA), tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor (PAI-1), and tissue factor (TF). Prostacyclin production was only stimulated at very high VAS/VEGF concentrations. Taken together, these results indicate that VAS/VEGF might be a potent inducer of neovascularization resulting from a direct interaction with endothelial cells. The angiogenic activity seems to be independent of the plasminogen activator or inhibitor system.
Low noise InAlAs/InGaAs HEMTs grown by MOVPE (2002)

We have demonstrated the MOVPE growth of high quality InAlAs/InGaAs on InP HEMT devices that are suitable for low noise amplifier applications. We have developed a growth process to reduce unwanted residual background charge typically found in MOVPE grown InAlAs/InGaAs HEMT structures to less than 9E9 cm/sup -2/. We have demonstrated the growth of HEMT devices over a wide range of sheet charge (/spl sim/4E10-4E12 cm/sup -2/) while maintaining Hall mobilities greater than 10,500 cm/sup 2//Vs. HEMT devices with gate length of 0.15 /spl mu/m were fabricated and tested. Excellent device performance is observed. Noise performance was measured from 226 GHz and S-parameter data was taken from 0.5-40 GHz. The unity current cutoff frequency of 108 GHz and minimum noise figure of 1.3 dB with associated gain of more than 10 dB at 26 GHz demonstrate that the MOVPE growth technique can be applied to the low cost production of InAlAs/InGaAs HEMT for RF and low noise amplifier applications.
RES-701-1, a novel and selective endothelin type B receptor antagonist produced by Streptomyces sp. RE-701. II. Determination of the primary sequence. (1994)

The structure of RES-701-1, a novel microbial endothelin type B receptor antagonist, was determined. Protein chemical data and FAB-MS have identified RES-701-1 to be a cyclic polypeptide consisting of 16 common L-amino acids. This compound is so stable against proteolysis that its enzymatic digestion under standard conditions proved to be very difficult. Therefore, the primary sequence of RES-701-1 was determined by the application of advanced protein chemical methods to be Gly1-Asn2-Trp3-His4-Gly5-Thr6-Ala7-Pro8-++ +Asp9-Trp10-Phe11-Phe12-Asn13- Tyr14-Tyr15-Trp16. The compound is cyclized between the beta-carboxyl group of Asp9 and the alpha-amino group of Gly1.
Chemokine receptor 9 high-expression involved in the migration and invasion of the non-small-cell lung cancer cells (2011)

Abstract Background: Metastasis is responsible for most cancer-related death, and the metastatic spread of neoplastic cells may be related to the ability of migration and invasion. Chemokine receptor 9 (CCR9) plays an important role in cutaneous melanoma and prostate cancer cells migration and invasion. Objective: Investigate the specific role of the chemokine-ligand (CCR9-CCL25) axis in the development of nonsmall cell lung cancer (NSCLC) metastasis. Methods: Semi-quantitative reverse transcriptase-PCR, western-blot, flow cytometry, migration, and invasion assays were used to examine the function of CCR9 in the NSCLC cells. Results: CCR9 was highly expressed in NSCLC patient cancer tissue. In addition, in vitro migration and invasion studies on human bronchial epithelial cells of the BEAS-2B and human squamous lung cancer cell lines NCI-H157 showed that migration in response to the CCL25 was inhibited by CCR9 antibody. Conclusion: CCR9 might play an important role in the migration and invasion of the NSCLC cells.
Comparative Study of Antenna Designs for RF Energy Harvesting (2013)

In the last few years, several antenna designs of rectenna that meet various objectives have been proposed for use in RF energy harvesting. Among various antennas, microstrip patch antennas are widely used because of their low profile, light weight, and planar structure. Conventional patch antennas are rectangular or circular in shape, but variations in their basic design are made for different purposes. This paper begins with an explanation and discussion of different designs, put forward with an aim of miniaturization, harmonic rejection, and reconfigurability. Finally, microstrip patch structured rectennas are evaluated and compared with an emphasis on the various methods adopted to obtain a compact rectenna, harmonic rejection functionality, and frequency and polarization selectivity.
Anemia and iron status in the free-living and institutionalized elderly in Kentucky. (1989)

A study of the iron status and anemia in 101 elderly persons, age 60 to 95, included 50 free-living and 51 institutionalized subjects. Daily iron intakes and biochemical parameters including hemoglobin, hematocrit, mean corpuscular hemoglobin concentration (MCHC), plasma iron levels and total iron binding capacity (TIBC) were determined. In the free-living group, only 4% male and 8% female subjects had iron-deficiency anemia. Whereas about 40% of the institutionalized group had iron deficiency anemia with low hemoglobin, hematocrit, MCHC, plasma iron levels, and elevated TIBC. Hemoglobin, hematocrit, MCHC and plasma iron levels were significantly higher, and TIBC was significantly lower in the free-living group than the institutionalized group. The lack of correlation between dietary iron intakes and plasma iron levels suggest that iron deficiency anemia in these elderly subjects was not due to lack of iron intakes. The possible causes might be medications and diseases in these elderly subjects.
Joint project for mechanical qualification of next generation high density package-on-package (PoP) with through mold via technology (2009)

This paper will summarize joint work between ST Microelectronics, Amkor Technology and Nokia; to qualify Amkor's through mold via (TMV™) bottom package technology for next generation high density PoP applications. The 12 × 12mm daisy chain test vehicle reported in this joint work includes a thin flip chip die in a fully molded bottom package with 516 bottom BGAs at 0.4mm pitch and 168 top solderable through mold vias at 0.5mm pitch. This paper will report the package level (moisture resistance, temperature cycling) and board level (temperature cycle, drop) qualification data against IC and handheld application requirements. Additional data for package warpage control and board level reliability for larger PoP applications using TMV technology will be included beyond what was reported at ECTC, SMTA International during 2008 and IMAPS Device Packaging in March 2009, based on a 14 × 14mm daisy chain test vehicle with 620 bottom BGAs at 0.4mm pitch and 200 top vias at 0.5mm pitch. Additional data on the TMV technology will be provided including: maximum die to package size design benefits for wirebond, stacked and flip chip die, coplanarity and package warpage measured by shadow moire across lead free SMT reflow profiles. JEDEC standardization work for next generation PoP applications will be provided for mechanical and high density electrical interface requirements driven by low power double data rate 2 memory (LP DDR2), in single and dual channel architectures which require 0.5 and 0.4mm pitch interfaces respectively.
Development of a beam propagation method to simulate the point spread function degradation in scattering media (2019)

Scattering is one of the main issues that limit the imaging depth in deep tissue optical imaging. To characterize the role of scattering, we have developed a forward model based on the beam propagation method and established the link between the macroscopic optical properties of the media and the statistical parameters of the phase masks applied to the wavefront. Using this model, we have analyzed the degradation of the point-spread function of the illumination beam in the transition regime from ballistic to diffusive light transport. Our method provides a wave-optic simulation toolkit to analyze the effects of scattering on image quality degradation in scanning microscopy. Our open-source implementation is available at https://github.com/BUNPC/Beam-Propagation-Method.
QSMxT: Robust masking and artifact reduction for quantitative susceptibility mapping (2021)

The two-pass masking and reconstruction procedure separates reliable from less reliable phase regions, enabling a more accurate QSM reconstruction that mitigates artifacts, operates without anatomical priors, and requires minimal parameter tuning. The technique and its integration within QSMxT makes QSM processing more accessible and robust to streaking artifacts.
THE STRUCTURE OF FUMAGILLIN1 (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE STRUCTURE OF FUMAGILLIN1D. S. Tarbell, R. M. Carman, D. D. Chapman, K. R. Huffman, and N. J. McCorkindaleCite this: J. Am. Chem. Soc. 1960, 82, 4, 1005–1007Publication Date (Print):February 1, 1960Publication History Published online1 May 2002Published inissue 1 February 1960https://pubs.acs.org/doi/10.1021/ja01489a067https://doi.org/10.1021/ja01489a067research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Data from Clinical Significance of Four Molecular Subtypes of Gastric Cancer Identified by The Cancer Genome Atlas Project (2023)

&lt;p&gt;7 figures and 7 Tables&lt;/p&gt;
Colorful XML (2004)

XML has a tree-structured data model, which is used to uniformly represent structured as well as semi-structured data, and also enable concise query specification in XQuery, via the use of its XPath (twig) patterns. This in turn can leverage the recently developed technology of structural join algorithms to evaluate the query efficiently. In this paper, we identify a fundamental tension in XML data modeling: (i) data represented as deep trees (which can make effective use of twig patterns) are often un-normalized, leading to update anomalies, while (ii) normalized data tends to be shallow, resulting in heavy use of expensive value-based joins in queries.Our solution to this data modeling problem is a novel multi-colored trees (MCT) logical data model, which is an evolutionary extension of the XML data model, and permits trees with multi-colored nodes to signify their participation in multiple hierarchies. This adds significant semantic structure to individual data nodes. We extend XQuery expressions to navigate between structurally related nodes, taking color into account, and also to create new colored trees as restructurings of an MCT database. While MCT serves as a significant evolutionary extension to XML as a logical data model, one of the key roles of XML is for information exchange. To enable exchange of MCT information, we develop algorithms for optimally serializing an MCT database as XML. We discuss alternative physical representations for MCT databases, using relational and native XML databases, and describe an implementation on top of the Timber native XML database. Experimental evaluation, using our prototype implementation, shows that not only are MCT queries/updates more succinct and easier to express than equivalent shallow tree XML queries, but they can also be significantly more efficient to evaluate than equivalent deep and shallow tree XML queries/updates.
Experimental Evaluation of the Structure Characterization of a Novel Hybrid Bump-Metal Mesh Foil Bearing (2015)

Rotors supported by gas foil bearings (GFBs) experience stability problem caused by subsynchronous vibrations. To obtain a GFB with satisfactory damping characteristics, this study presented a novel hybrid bump-metal mesh foil bearing (HB-MMFB) that consists of a bump foil and metal mesh blocks in an underlying supporting structure, which takes advantage of both bump-type foil bearings (BFBs) and MMFBs. A test rig with a nonrotating shaft was designed to estimate structure characterization. Results from the static load tests show that the proposed HB-MFBs exhibit an excellent damping level compared with the BFBs with a similar size because of the countless microslips in the metal mesh blocks. In the dynamic load tests, the HB-MFB with a metal mesh density of 36% presents a viscous damping coefficient that is approximately twice that of the test BFB. The dynamics structural coefficients of HB-MFBs, including structural stiffness, equivalent viscous damping, and structural loss factor, are all dependent on excitation frequency and motion amplitude. Moreover, they exhibit an obvious decrease with the decline in metal mesh density.
Effect of salicylate on the distribution of sulfonamides to red blood cells in rat. (1979)

Effects of salicylate on the distribution of five sulfonamides to red blood cells in rat were studied in vitro and in vivo. The distribution of sulfonamides to red blood cells in whole blood in vitro increased with an increase in their concentration in blood. But, in cell suspension without plasma, the distribution of the drugs to red blood cells was not influenced by their concentration. The distribution of sulfonamides except for sulfanilamide to red blood cells was enhanced by the addition of salicylate in whole blood. But, in cell suspension, the effect of salicylate was not observed. Addition of rat plasma to the cell suspension reduced the distribution of sulfonamides to red blood cells. It was considered that the unbound fraction of sulfonamides was responsible for their distribution to red blood cells. Thus, it may be concluded that salicylate inhibits the binding of sulfonamides to plasma protein, resulting in an increase in their unbound fraction and an enhancement of the distribution of sulfonamides to red blood cells.
Exhaustive experimental study of tunnel field effect transistors (TFETs): From materials to architecture (2009)

The goal of this paper is to present and to analyze the tunnel FET and its specific properties (small subthreshold swing, very low OFF currents). We investigate the opportunities offered by this sub-ldquokT/qrdquo swing device and review the issues that TFET has to overcome (ambipolar behaviour, low ON current) for future circuit applications. For that purpose we report on experimental results on SOI, Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> OI & GeOI TFETs, fabricated using a fully depleted SOI CMOS process flow with high-k & metal gate stack.
Second primary carcinoma arising on a flap: a new primary or a relapse? (2023)

Free flaps or pedicle flaps are the mainstay of cancer surgery in the head and neck area. However, their long-term sequelae are still poorly understood. Among these, the development of a secondary primary tumor on a flap is a rare and uncertain reported event. Methods: A computer-aided systematic literature search was performed by using the PubMed, EMBASE and Cochrane Library databases. A systematic review of the literature, following the PRISMA checklist, was carried out with the aim of analyzing all the citations reporting this second primary, with attention to risk factors, behavior, etiological causes. Results: Overall, 27 cases of second primary squamous cell carcinoma arising on a pedicle or free flap were identified. In addition, other three cases were discussed. Conclusions: Persistent exposure to oral stimuli such saliva, oral microbiome, smoke or a colonization by the adjacent mucosa were considered as a possible cause of second primary carcinoma. Although rare, a new neoplasm onset should know and considered as a new concept in the follow-up of patients undergoing reconstruction with free or pedicle flaps.
FIGURE 5 from Kinase Inhibitor Pulldown Assay Identifies a Chemotherapy Response Signature in Triple-negative Breast Cancer Based on Purine-binding Proteins (2023)

&lt;p&gt;The prognosis effects of the KIPA-based PBP signature in METABRIC dataset. &lt;b&gt;A,&lt;/b&gt; Forest plot shows HRs and &lt;i&gt;P&lt;/i&gt; values for disease-specific survival associated with the PBP signature and seven signature genes. HR and 95% confidence intervals were based on categorizing TNBC samples using a median mRNA expression cutoff for each gene or the PBP signature score in the METABRIC dataset. Survival analysis was also performed for clinical factors (lymph nodes number, tumor size, and tumor grade). Blue boxes indicate univariate analysis, and red boxes indicate multivariate analysis. &lt;b&gt;B,&lt;/b&gt; Kaplan–Meier curve shows disease-specific survival of TNBC samples from the METABRIC dataset. Samples were categorized into mRNA-based PBP signature score high and low group based on the median cutoff.&lt;/p&gt;
Stripping Voltammetry of Barium Ion in the Presence of Lead (2001)

The use of differential pulse anodic stripping voltammetry (DPASV) with a glassy carbon/mercury film electrode for the simultaneous detection of barium and lead is observed. The use of various electrolytes in partially aqueous or fully aqueous solution gives a reproducible capacitance peak for Ba and a stripping peak for Pb. These results are accomplished under acidic conditions (pH 2 to 4). A response is obtained for each metal down to 100 ng.
The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events (2021)

Atherosclerosis is an underlying cause of a broad array of cardiovascular diseases characterized by plaques, arterial wall thickening initiated by hyperlipidemia, pro-inflammatory signals, endothelial dysfunction and the influx of inflammatory cells. By still incompletely characterized mechanisms, these plaques can destabilize or erode, leading to thrombosis and blood vessel occlusion and becomes clinically manifest as angina pectoris, myocardial infarction (MI) or stroke. Among the several blood cell types that are involved in the development of atherosclerosis, the role of platelets during the thrombotic occlusion of ruptured or eroded plaques is well established and clinically exploited as evident by the extensive use of platelet inhibitors. However, there is increasing evidence that platelets are also involved in the earlier stages of atheroma development by exhibiting pro-inflammatory activities. The scope of this review is to describe the role of platelets in the initiation and propagation stages of atherosclerosis and beyond; in atherothrombotic complications.
Measurement of Exciton and Trion Energies in Multistacked hBN/WS2 Coupled Quantum Wells for Resonant Tunneling Diodes (2020)

Quantum confinements, especially quantum in narrow wells, have been investigated because of their controllability over electrical parameters. For example, quantum dots can emit a variety of photon wavelengths even for the same material depending on their particle size. More recently, the research into two-dimensional (2D) materials has shown the availability of several quantum mechanical phenomenon confined within a sheet of materials. Starting with the gapless semimetal properties of graphene, current research has begun into the excitons and their properties within 2D materials. Even for simple 2D systems, experimental results often offer surprising results, unexpected from traditional studies. We investigated a coupled quantum well system using 2D hexagonal boron nitride (hBN) barrier as well as 2D tungsten disulfide (WS<sub>2</sub>) semiconductor arranged in stacked structures to study the various 2D to 2D interactions. We determined that for hexagonal boron nitride-tungsten disulfide (hBN/WS<sub>2</sub>) quantum well stacks, the interaction between successive wells resulted in decreasing bandgap, and the effect was pronounced even over a large distance of up to four stacks. Additionally, we observed that a single layer of isolating hBN barriers significantly reduces interlayer interaction between WS<sub>2</sub> layers, while still preserving the interwell interactions in the alternative hBN/WS<sub>2</sub> structure. The methods we used for the study of coupled quantum wells here show a method for determining the respective exciton energy levels and trion energy levels within 2D materials and 2D materials-based structures. Renormalization energy levels are the key in understanding conductive and photonic properties of stacked 2D materials.
SIP: A routing protocol (2002)

Routing in the Internet has traditionally implied shunting packets based on layer 2 (network layer of the IP reference model) addresses. While that may have been adequate in the past, the new protocols of the Internet are moving routing to the highest layer — the application layer. These protocols include established ones such as simple mail transport protocol (SMTP) and new ones such as session initiation protocol (SIP). One could argue that e-mail is, in a generalized form, a routing engine: Users can configure it to route e-mail messages to the location where they happen to be. Most recent protocols such as SIP add multiple novel dimensions to application-layer routing, such as mobility and end-user configuration. At its core, a SIP call controller (better known as a SIP proxy) is a pure routing engine. It analyzes an incoming invitation and makes a decision, after accounting for various factors, on how to best route the message. In this paper, we take a deeper look at how these new protocols route messages and, in the process, make the Internet that much more indispensable.3