gebhart/patrepeval huggingface dataset:
Live generation of interactive non-verbal behaviours (2012)

Psychology, robotic and virtual agents communities commonly claim that to enable natural interaction to take place within dyad of agents, the dyad must be the siege of dynamical coupling: to give to their partners a feeling of natural interaction, interactants be human, robotic or virtual, must be able to make the dynamic of their behaviour emerge both from their own internal states and from their partner's behaviours. However, most virtual agents engines for interactions model communication as a step by step phenomenon, where pre-scripted signals and corresponding feedbacks alternate. We propose here an agent architecture which generates non-verbal behaviours in live, influenced by both the internal state of the agent and the continuously incoming reaction of its partner. This architecture enables an agent facing either another agent or a human, to emphasise shared behaviours (called Snowball effect), to decrease un-shared behaviours as well as to align dynamically with its partner's behaviour.
Resonating Valence Bond Theory of Coupled Heisenberg Chains (1994)

Using numerical results from a density matrix renormalization group study as a guide, we develop a resonating valence bond (RVB) theory for coupled Heisenberg chains. We argue that simple topological effects mandate a short-range RVB description of systems with an even number of chains ${n}_{c}$, with a spin gap, short-range correlations, and confinement of topological spin defects. Odd-${n}_{c}$ systems have long-range RVB ground states, no gap, and power-law correlations.
Related Article from Screening for Oral Premalignancy and Cancer: What Platform and Which Biomarkers? (2023)

Related Article from Screening for Oral Premalignancy and Cancer: What Platform and Which Biomarkers?
CaO-Based Pellets Supported by Calcium Aluminate Cements for High-Temperature CO2 Capture (2009)

The development of highly efficient CaO-based pellet sorbents, using inexpensive raw materials (limestones) or the spent sorbent from CO2 capture cycles, and commercially available calcium aluminate cements (CA-14, CA-25, Secar 51, and Secar 80), is described here. The pellets were prepared using untreated powdered limestones or their corresponding hydrated limes and were tested for their CO2 capture carrying capacities for 30 carbonation/calcination cycles in a thermogravimetric analyzer (TGA). Their morphology was also investigated by scanning electron microscopy (SEM) and their compositions before and after carbonation/calcination cycleswere determined by X-ray diffraction (XRD). Pellets prepared in this manner showed superior behavior during CO2 capture cycles compared to natural sorbents, with the highest conversions being > 50% after 30 cycles. This improved performance was attributed to the resulting substructure of the sorbent particles, i.e., a porous structure with nanoparticles incorporated. During carbonation/calcination cycles mayenite (Ca12Al14O33) was formed, which is believed to be responsible for the favorable performance of synthetic CaO-based sorbents doped with alumina compounds. An added advantage of the pellets produced here is their superior strength, offering the possibility of using them in fluidized bed combustion (FBC) systems with minimal sorbent loss due to attrition.
Purification of Fish Oil Ethyl Esters by High-Speed Countercurrent Chromatography Using Non-aqueous Solvent Systems (1996)

Abstract High-speed countercurrent chromatography (HSCCC) was applied to purification of fish oil ethyl esters (FOEE). The CCC separations were performed using non-aqueous two-phase solvent systems in two steps: The first purification was carried out with a hexane-acetonitrile system where 30 mL of crude FOEE was cleaned in 140 min yielding 23.1 mL of refined FOEE. The product was colorless and free of saturated fatty acid esters. The second and final purification was performed with a hexane-dichloromethane-acetonitrile (5 : 1:4, v/v/v) where 1 g of the refined FOEE was resolved into three fractions, ethyl hexadecenoate, ethyl octadecenoate and the third composed of 56.4% of ethyl docosahexaenoate and 39.3% of ethyl eicosapentenoate. The separation was completed in 145 min. However, polyunsaturated fatty acids are not resolved with this solvent system due to their low partition coefficients.
Structure, activity and evolution of the group I thiolactone peptide quorum‐sensing system ofStaphylococcus aureus (2001)

In Staphylococcus aureus, the agr locus is responsible for controlling virulence gene expression via quorum sensing. As the blockade of quorum sensing offers a novel strategy for attenuating infection, we sought to gain novel insights into the structure, activity and turnover of the secreted staphylococcal autoinducing peptide (AIP) signal molecules. A series of analogues (including the L-alanine and D-amino acid scanned peptides) was synthesized to determine the functionally critical residues within the S. aureus group I AIP. As a consequence, we established that (i) the group I AIP is inactivated in culture supernatants by the formation of the corresponding methionyl sulphoxide; and (ii) the group I AIP lactam analogue retains the capacity to activate agr, suggesting that covalent modification of the AgrC receptor is not a necessary prerequisite for agr activation. Although each of the D-amino acid scanned AIP analogues retained activity, replacement of the endocyclic amino acid residue (aspartate) located C-terminally to the central cysteine with alanine converted the group I AIP from an activator to a potent inhibitor. The screening of clinical S. aureus isolates for novel AIP groups revealed a variant that differed from the group I AIP by a single amino acid residue (aspartate to tyrosine) in the same position defined as critical by alanine scanning. Although this AIP inhibits group I S. aureus strains, the producer strains possess a functional agr locus dependent on the endogenous peptide and, as such, constitute a fourth S. aureus AIP pheromone group (group IV). The addition of exogenous synthetic AIPs to S. aureus inhibited the production of toxic shock syndrome toxin (TSST-1) and enterotoxin C3, confirming the potential of quorum-sensing blockade as a therapeutic strategy.
Trace-gas Spectroscopy of Methane using a Monolithically Integrated Silicon Photonic Chip Sensor (2019)

We present a monolithically integrated photonic sensor incorporating an on-chip III-V laser, detector, sealed reference cell, and sensing waveguide capable of near-infrared absorption spectroscopy of methane near λ = 1651 nm. Sub-100 ppmv∙Hz-1/2 sensitivities are demonstrated.
Principles of Context-Based Machine Translation (2016)

This article defines a Framework for Machine Translation Evaluation (Femti) which relates the quality model used to evaluate a machine translation system to the purpose and context of the system. Our proposal attempts to put together, into a coherent picture, previous attempts to structure a domain characterised by overall complexity and local difficulties. In this article, we first summarise these attempts, then present an overview of the ISO/IEC guidelines for software evaluation (ISO/IEC 9126 and ISO/IEC 14598). As an application of these guidelines to machine translation software, we introduce FEMTI, a framework that is made of two interrelated classifications or taxonomies. The first classification enables evaluators to define an intended context of use, while the links to the second classification generate a relevant quality model (quality characteristics and metrics) for the respective context. The second classification provides definitions of various metrics used by the community. Further on, as part of ongoing, long-term research, we explain how metrics are analyzed, first from the general point of view of meta-evaluation, then focusing on examples. Finally, we show how consensus towards the present framework is sought for, and how feedback from the community is taken into account in the Femti life-cycle.
ChemInform Abstract: PREPARATION OF CHIRAL DIPHENYL SUBSTITUTED POLYETHER‐DIESTER COMPOUNDS (1982)

Abstract Aus dem Bis‐carbonsäurechlorid (I) entsteht mit dem Diol (II) das Cyclisierungsprodukt (III).
Figure S2 from Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance (2023)

&lt;p&gt;Fig. S2. N-acetyl alanine does not protect from gemcitabine toxicity and nucleoside levels in PDAC cells are not effected by treatment with gemcitabine or conditioned media (A) Dose response curves with N-acetyl-alanine without (solid lines) or with (dashed lines) 0.025 uM gemcitabine. The viability after treatment with PSC2 CM is also shown. Data show three biological replicates +/- SEM. (B-E) Absolute quantification of the indicated species in within PDAC cells after the indicated treatment. Data show 3 biological replicates +/- SEM.&lt;/p&gt;
Alumina fibre FP (1980)

Abstract A new experimental inorganic fibre currently under development at the Du Pont Company is a continuous filament, polycrystalline a-alumina yarn designated Fibre FP. This fibre is suitable for reinforcing a variety of materials, especially non-ferrous metal castings because of a combination of properties such as high strength and modulus, stability at elevated temperatures, composite castability and potentially low cost. Fibre FP, essentially &amp;gt; 99 % a-Al2O3, is made by a novel continuous ceramic fibre process utilizing low cost textile fibre spinning technology and is produced as a yarn containing 210 filaments. The modulus of Fibre FP is 379 GPa (55 x 106 lbf in-2) with a tensile strength of 1380 MPa (200000 lbf in-2). The room temperature strength and modulus of the fibre are retained to about 1000 °C. Recently, higher strength FP fibres with a tensile strength of 2070 MPa (300000 lbf in-2) have been demonstrated on a laboratory scale.
FinFET process refinements for improved mobility and gate work function engineering (2003)

Process refinements to improve the performance of FinFETs are described. Hydrogen annealing is shown to provide high surface quality on etched fin sidewalls for improved drive current and noise performance. Appropriate V/sub t/ is achieved in lightly doped p-channel FinFETs using Molybdenum (Mo) as the gate-electrode material for the first time. Multiple values of V/sub t/ are achieved via gate work function engineering by selective implantation of Mo.
Virtual Issue on New Physical Insights (2018)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTVirtual Issue on New Physical InsightsGeorge C. SchatzGeorge C. SchatzMore by George C. Schatzhttp://orcid.org/0000-0001-5837-4740Cite this: J. Phys. Chem. B 2018, 122, 16, 4385–4387Publication Date (Web):April 26, 2018Publication History Published online26 April 2018Published inissue 26 April 2018https://pubs.acs.org/doi/10.1021/acs.jpcb.8b01563https://doi.org/10.1021/acs.jpcb.8b01563editorialACS PublicationsCopyright © 2018 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views626Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (242 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Interfaces,Materials,Order,Physical chemistry,Two dimensional materials Get e-Alerts
Evidence for Cooperative and Domain-specific Binding of the Signal Transducing Adaptor Molecule 2 (STAM2) to Lys63-linked Diubiquitin (2012)

As the upstream component of the ESCRT (endosomal sorting complexes required for transport) machinery, the ESCRT-0 complex is responsible for directing ubiquitinated membrane proteins to the multivesicular body pathway. ESCRT-0 is formed by two subunits known as Hrs (hepatocyte growth factor-regulated substrate) and STAM (signal transducing adaptor molecule), both of which harbor multiple ubiquitin-binding domains (UBDs). In particular, STAM2 possesses two UBDs, the VHS (Vps27/Hrs/Stam) and UIM (ubiquitin interacting motif) domains, connected by a 20-amino acid flexible linker. In the present study, we report the interactions of the UIM domain and VHS-UIM construct of STAM2 with monoubiquitin (Ub), Lys(48)- and Lys(63)-linked diubiquitins. Our results demonstrate that the UIM domain alone binds monoubiquitin, Lys(48)- and Lys(63)-linked diubiquitins with the same affinity and in the same binding mode. Interestingly, binding of VHS-UIM to Lys(63)-linked diubiquitin is not only avid, but also cooperative. We also show that the distal domain of Lys(63)-linked diubiquitin stabilizes the helical structure of the UIM domain and that the corresponding complex adopts a specific structural organization responsible for its greater affinity. In contrast, binding of VHS-UIM to Lys(48)-linked diubiquitin and monoubiquitin is not cooperative and does not show any avidity. These results may explain the better sorting efficiency of some cargoes polyubiquitinated with Lys(63)-linked chains over monoubiquitinated cargoes or those tagged with Lys(48)-linked chains.
Perception methods for continuous humanoid locomotion over uneven terrain (2016)

Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2016.
The human gastric colonizer Helicobacter pylori: a challenge for host-parasite glycobiology (2000)

The Gram-negative bacterium Helicobacter pylori was first described in 1983 and currently represents one of the most active single research topics in biomedicine. It is specific for the human stomach and chronically colonizes a majority of the global population, which results in a symptom-free local inflammation. In 10-20% of carriers, gastroduodenal disease develops, including gastric or duodenal ulcer, and atrophic gastritis, which is a precondition to gastric cancer. A probable long coevolution of microbe and homo sapiens in a restricted niche has apparently generated a complex and sophisticated interplay. Access to complete bacterial genome sequences assists in a comparative functional characterization. A dynamic glycosylation of both microbe and host cells is of growing interest to analyze. Several glycoforms of bacterial surface lipopolysaccharides show advanced molecular mimicry of host epitopes and a distinct phase variation. An unusually large family of 32 outer membrane proteins probably reflects the complex interrelationship with the host. The unique diversity found for carbohydrate-binding specificities may be mediated by these surface proteins, of which the Lewis b-binding adhesin is the only known example so far, and these binding activities are subject to phase variation. The host mucosa glycosylation may also vary with different conditions, allowing a modulated crosstalk between microbe and host. The bacterium actively stimulates the host inflammatory response, apparently for nutritional purposes, and there is no evidence for a spontaneous elimination of the microbe. Colonization appears to be preventive for upper stomach and esophageal diseases. Current antibiotic treatment eradicates the microbe and cures ulcer disease. Alternative approaches must, however, be developed for a potential global prevention of disease.
Novel dihydro-β-agarofuran sesquiterpenes as potent modulators of human P-glycoprotein dependent multidrug resistance (2009)

P-Glycoprotein (Pgp) overexpression is one factor contributing to multidrug resistance (MDR) in cancer cells and represents one drawback in the treatment of cancer. In an attempt to find more specific and less toxic anticancer MDR-reversal agents, we report herein the isolation, structure elucidation and biological activity of nine new (, and ) and seven known (, and ) dihydro-beta-agarofuran sesquiterpenes from the leaves of Celastrus vulcanicola. Their stereostructures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR techniques, CD studies and biogenetic means. All the compounds were assayed on human MDR1-transfected NIH-3T3 cells, in order to determine their ability to reverse the MDR phenotype due to Pgp overexpression. Six compounds from these series (, , , , and ) showed an effectiveness that was similar to (or higher than) the classical Pgp reversal agent verapamil for the reversal of resistance to daunomycin and vinblastine. The structure-activity relationships are discussed.
A 96.4 dB high-pass delta-sigma modulator with dynamic biasing and tree-structured DEM (2016)

This paper presents a switched-capacitor high-pass delta-sigma modulator that can directly convert a chopper modulated signal to the digital domain. Low power consumption is achieved by employing inverter-based amplifiers and dynamic biasing in the first amplifier with relaxed slew-rate requirements as a result of the multi-bit quantization. The mismatch errors in the switched-capacitor DAC are first-order noise shaped by a tree-structured dynamic element matching encoder. Schematic level simulations show that the high-pass modulator achieves a peak SNDR of 96.4 dB and a SFDR of 101 dBc over a bandwidth of 300 Hz. The total estimated power consumption of the modulator is 19.56 μW leading to a figure-of-merit of 0.6 pJ/conv.
Magnetization reversal process and domain dynamics in thermomagnetic recording of TbFeCo amorphous films (1990)

The domain wall dynamics in thermomagnetic recording of TbFeCo amorphous films is interpreted in terms of a model comprising magnetization reversal nucleation followed by a wall displacement process. The nucleation of the reversed domain from the saturated magnetization state occurs with a field usually observed as a nominal coercivity in Kerr or magnetization hysteresis loops. The concept of wall coercivity, which is often smaller than the nucleation field, is explicitly incorporated in the stability condition of the cylindrical domain during the wall displacement process. The model predicts both the recorded domain size and its dependence on recording power and applied field.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Embolic effects of superabsorbent polymer microspheres in rabbit renal model: comparison with tris-acryl gelatin microspheres and polyvinyl alcohol. (2005)

SAP-MS resulted in targeted end-organ infarction in the rabbit renal model and showed different mechanical properties from other agents.
The establishment of clonally derived chicken embryonic fibroblast cell line (CSC) with high transfection efficiency and ability as a feeder cell (2018)

This study established a single cloned chicken embryonic fibroblast (CEF) cell line. It solves the main problem of the instability of a cultured primary cell and its impact on the experiment. In this study, CEF pass through this crisis and formed a continuous cell line after subculture. We isolated single postcrisis CEF by a mouth pipette under a convert microscope then established a single cloned cell line named CSC-1-5 which passaged continuously from 96-well plates to 60 mm culture plates. CSC has a normal chicken diploid karyotype, no tumorigenicity, and a high G2/M phase cell ratio. We found that Fugene could mediate the transfection of CSCs efficiently; it was significantly improved compared with the primary cells. It could also promote the proliferation of chicken embryonic stem cell as a feeder layer.
Ventilatory Responses to Acute and Sustained Hypoxia During Sevoflurane Anesthesia in Women (1999)

We investigated the isocapnic hypoxic (i.e., pulse oximetry monitored arterial saturations 70%-75%) ventilatory response (HVR) for 20 min in the awake state and during sevoflurane anesthesia at an end-tidal concentration of 1.6% in eight healthy (ASA physical status I) women. Our aims were to determine if a prolonged isocapnic hypoxic period during sevoflurane anesthesia showed a biphasic response pattern (i.e., an initial acute HVR followed by a decline to a lowered sustained HVR) and, if so, to quantify to what extent the acute and sustained HVRs were depressed by anesthesia. The study was conducted before laparoscopic gynecological surgery. Pneumotachography and in-line infrared capnography were used. The pattern of awake biphasic HVR was maintained during anesthesia but was depressed during both the acute and the sustained phases by 60% and 70%, respectively. Further, HVR during anesthesia was accomplished by an increase in respiratory rate, in contrast to an increase in tidal volume in the awake state. In conclusion, sevoflurane anesthesia at 1.6% depresses HVR in women, but the biphasic response is maintained. Implications: Acute and sustained hypoxic ventilatory responses were investigated in eight women before and during sevoflurane anesthesia. A biphasic ventilatory response was persistent but blunted during anesthesia. (Anesth Analg 1999;89:209-14)
Neuroligin-2 Deletion Selectively Decreases Inhibitory Synaptic Transmission Originating from Fast-Spiking but Not from Somatostatin-Positive Interneurons (2009)

Neuroligins are cell adhesion molecules involved in synapse formation and/or function. Neurons express four neuroligins (NL1-NL4), of which NL1 is specific to excitatory and NL2 to inhibitory synapses. Excitatory and inhibitory synapses include numerous subtypes. However, it is unknown whether NL1 performs similar functions in all excitatory and NL2 in all inhibitory synapses, or whether they regulate the formation and/or function of specific subsets of synapses. To address this central question, we performed paired recordings in primary somatosensory cortex of mice lacking NL1 or NL2. Using this system, we examined neocortical microcircuits formed by reciprocal synapses between excitatory neurons and two subtypes of inhibitory interneurons, namely, fast-spiking and somatostatin-positive interneurons. We find that the NL1 deletion had little effect on inhibitory synapses, whereas the NL2 deletion decreased (40-50%) the unitary (cell-to-cell) IPSC amplitude evoked from single fast-spiking interneurons. Strikingly, the NL2 deletion had no effect on IPSC amplitude evoked from single somatostatin-positive inhibitory interneurons. Moreover, the frequency of unitary synaptic connections between individual fast-spiking and somatostatin-positive interneurons and excitatory neurons was unchanged. The decrease in unitary IPSC amplitude originating from fast-spiking interneurons in NL2-deficient mice was due to a multiplicative and uniform downscaling of the amplitude distribution, which in turn was mediated by a decrease in both synaptic quantal amplitude and quantal content, the latter inferred from an increase in the coefficient of variation. Thus, NL2 is not necessary for establishing unitary inhibitory synaptic connections but is selectively required for "scaling up" unitary connections originating from a subset of interneurons.
Functional characterization of calcium sensing receptor polymorphisms and absence of association with indices of calcium homeostasis and bone mineral density (2006)

Our study, which was sufficiently powered to detect effects that would explain up to 5%, but not less than 1%, of the variance has revealed that the three CaSR polymorphisms of the coding region have no major influence on indices of calcium homeostasis in this female population, and that they do not alter receptor function.