gebhart/patrepeval huggingface dataset:
Debate: Intermittent Hemodialysis versus Continuous Kidney Replacement Therapy in the Critically Ill Patient: The Argument for CKRT (2023)

Continuous kidney replacement therapy (CKRT) is well entrenched as one of the dominant KRT modalities in modern critical care practice. Since its introduction four decades ago, there have been considerable innovations in CKRT machines that have improved precision, safety, and simplicity. CKRT is the preferred KRT modality for critically ill patients with hemodynamic instability. Early physical therapy and rehabilitation can be feasibly and safely provided to patients connected to CKRT, thus obviating concerns about immobility. Although randomized clinical trials have not shown a mortality difference when comparing CKRT and intermittent hemodialysis, CKRT allows precision delivery of solute and fluid removal that can be readily adjusted in the face of dynamic circumstances. Accumulated evidence from observational studies, although susceptible to bias, has shown that CKRT, when compared with intermittent hemodialysis, is associated with better short- and long-term kidney recovery and KRT independence. Critical care medicine encompasses a wide range of sick patients, and no single KRT modality is likely to ideally suit every patient in every context and for every condition. The provision of KRT represents a spectrum of modalities to which patients can flexibly transition in response to their evolving condition. As a vital tool for organ support in the intensive care unit, CKRT enables the personalization of KRT to meet the clinical demands of patients during the most severe phases of their illness.
Pilot study on photodynamic therapy for acne using chlorophyll: Evaluator-blinded, split-face study (2011)

Sirs,Since its ability of producing radical oxygen species was known, chlorophyll's usefulness in photodynamic therapy (PDT) for acne has received great attention (1,2). However, the effect of chlo...
Considerations Taken in Developing the Frequency Assignment Guidelines for Communications in the Mars Region Provided in SFCG Recommendation 22-1, (SFCG Action Item No. 23/10) (2004)

In the 23'd Annual SFCG meeting in San Diego, CA, the SFCG created SFCG Action Item No. 23/10 to provide a readable summary of the work done by the Mars Interim Working Group (MIWG). The SFCG created the MIWG to develop a frequency plan for future Mars missions. The working group has produced a number of documents resulting in a recommendation, SFCG Rec 22-1 [1], titled Frequency Assignment Guidelines for Communications in Mars Region, including a frequency plan for the Mars Region. This document is prepared in response to the SFCG Action Item to provide an overview of the considerations taken when selecting the frequencies and to point out where detailed information of the considerations can be found.
In vivo fluorescence determinations of phytoplankton chlorophyll a (1977)

The in vivo fluorescence yield of chlorophyll a in Chlorella pyrenoidosa is shown to vary with the availability of nitrate, trace elements, and with the presence of mercury. The fluorescence yield of Phaeodactylum tricornutum also varies with culture conditions and comparisons of Cyclotella nana and Chaetoceros galvestonensis show a species‐dependent variation. Both types of yield fluctuations are eliminated when photosynthetic electron transport is blocked by adding 3‐(3,4dichlorophenyl)‐1,1‐dimethylurea (DCMU) to phytoplankton: the in vivo fluorescence yield becomes maximal and a constant function of cellular chlorophyll a , regardless of growth conditions or of the species examined. Preliminary observations of samples from the Caribbean Sea also indicate a constant in vivo fluorescence yield in the presence of DCMU.
Introduction to BioMEMS (2016)

The entire scope of the BioMEMS field-at your fingertipsHelping to educate the new generation of engineers and biologists, Introduction to BioMEMS explains how certain problems in biology and medicine benefit from and often require the miniaturization of devices. The book covers the whole breadth of this dynamic field, including classical microfabr
Multimedia Data Management: Using Metadata to Integrate and Aplly Digital Media (1998)

This book brings together the foremost experts from around the world to give the latest developments in managing digital media in information systems. This book offers real guidance on creating and using metadata--data that's extracted from data to be stored--for use in the complex job of managing multimedia. Packed with new insights, new technologies, and information on practices and standards, Multimedia Data Management brings you up to speed on metadata definitions, types, and tactics of all variety of digital media, including images, maps, video, and speech. This state-of-the-art guide to managing multimedia digital data takes the reader on an incisive and up-to-the-minute tour of metadata discoveries. And it clearly shows the reader areas waiting to be explored. This book gives an in-depth view of such tasks as: organizing and indexing a collection of digital images for efficient querying, navigation, and browsing; exploiting hierarchical, spatial, temporal, and evolutionary semantics for representing and accessing medical images; simultaneously accessing speech and text documents; using standards and research extensions in representing, storing, and exchanging geo-spatial and environmental data; characterizing video metadata by the analysis of applications and the nature of queries, for content-based processing; rendering personalized video delivery; using mixed-media to formulate queries in different media types; building and exploiting indexing vocabularies and ontologies; achieving interoperability in digital libraries and repositories of various media. In the words of the editors, this book takes you on a journey towards infocosm, a society in which people will have information anywhere, and time, and in many forms, for effective decision-making, better learning, and more fun.
32‐Channel self‐grounded bow‐tie transceiver array for cardiac MR at 7.0T (2021)

The compact SGBT building block facilitates a modular high-density array that supports accelerated and high spatial resolution CMR at 7.0T. The array provides a technological basis for future clinical assessment of parallel transmission techniques.
Effects of Anthropogenic Activities on Okoklo Forest Reserve in Benue State, Nigeria (2017)

Developing countries including Nigeria are saddled with problems emanating from environmental deterioration which has great impact on the forests. This study investigated the anthropogenic activities in Okoklo Forest Reserve Benue State to determine their implication on the sustainable management of forests. Vegetation survey method and questionnaire were employed to determine the effects of human activities on the reserve. A stratified random sampling design was used in the study for Tectona grandis and Gmelina arborea. Three (3) plots of 20 m x 20 m were randomly laid in each compartment of the plantation. The plots were located at least 50 m apart. A total of six (6) sample plots of 20 m x 20 m totalling 400 m 2 were laid. In each of the 20x 20 study plots, trees > 20 cm girth at breast height (gbh) were identified, counted and their girth measured. The girth of trees were grouped into six classes and the frequency of each were indicated. The study revealed that urbanization, fuel wood collection, bush burning, logging and land clearing ranked the major anthropogenic activities affecting sustainable forest management. It was observed that the class 41-50 had recorded the highest number of trees for all the species while no tree was recorded in the 20-30 class. The study therefore concluded that there was degradation of forest which could lead to complete loss of forests and recommended
Determining the clinical value of germline genetic testing coupled with tumor mutation profiling. (2017)

1577 Background: Somatic mutation analysis by next-generation sequencing (NGS) is an expanding clinical assessment offered to cancer patients. Studies report that 4–12% of patients have a positive tumor mutation profiling (TMP) result in a known cancer predisposition gene also identified in their germline, which has potential implications for the patient’s acute treatment, ongoing surveillance, and the screening of family members. We report a series of patients with TMP coupled with germline genetic testing and include yield of pathogenic germline mutations, discordance between germline and TMP findings, and potential clinical impact. Methods: Our study used de-identified data from 182 consecutive patients who underwent TMP followed by germline testing with an NGS-based hereditary cancer gene panel. Results: 50/182 cases (27%) had one or more likely pathogenic or pathogenic (LP/P) germline variants, which is higher than previous reports. Among these 50, 28 (56%) met guidelines for germline testing by personal or family history criteria, 10 (20%) met recently established NCCN criteria for germline testing of patients with BRCA1/2 tumor variants, and 12 (24%) had TMP results that suggested a germline mutation but did not meet any guidelines for germline testing. We identified 52 LP/P germline variants in BRCA2 (17), BRCA1 (7), PALB2 (6), MUTYH (5), CHEK2 (2), and 15 other genes, all with established guidelines that would impact the clinical management of patients and their family members. In 9/50 cases, germline testing revealed variants that were absent in TMP results and provided new information with clinical implications for patients and their families, including variants in BRCA1 and CHEK2. Conclusions: In TMP patients, 50 of 182 had a medically actionable germline mutation with established management guidelines. Among these 50, 12 (24%) met neither current personal or family criteria nor the latest NCCN guidelines for germline testing in patients with TMP. Also striking were nine patients whose germline LP/P mutations were absent in TMP results. These data suggest that indications for germline testing of cancer patients must be expanded to avoid missing important germline findings in patients undergoing TMP.
Towards dextrous manipulation using manipulation manifolds (2008)

In dextrous manipulation, the implementation of manipulation movements still is a complex and intricate undertaking. Often, a lot of object physics and modelling effort has to be incorporated into a controller working only for a very restricted task specification and performing quite artificially looking movements. In this paper, we present the first steps towards a representation of manipulation movements recorded from human demonstration which facilitates later application and promotes natural motion. We use manifolds of hand postures embedded in the finger joint angle space which are constructed such that manipulation parameters including the advance in time are represented by distinct manifold dimensions. This allows for purposive navigation within such manifolds. We present the manifold construction using the Unsupervised Kernel Regression (UKR) and the way of applying it for manipulation in the example of turning a bottle cap in a physics-based simulation.
Typing of DNA HLA-DQα Alleles Extracted from Human Nail Material Using Polymerase Chain Reaction (1995)

The deoxyribonucleic acid (DNA) typing of human Leukocyte Antigen (HLA) DQ alpha from human fingernails is described. HLA-DQ alpha genotypes can be accurately determined from clipped fingernails. We have typed 26 nails accurately, while one did not give any type since that one sample did not amplify due to the low quantity of DNA. The cut off limit for the digested material to be amplified is approximately 9 mgs of nail material.
Heterogenous Public Safety Wireless Networks with mmWave Small Cells: An IAB-based Approach (2023)

An efficient public safety communication network seeks minimal response time, optimal coordination between the disaster site and rescue team, with adequate situational awareness. Such a network requires an enduring and reliable architecture. This paper proposes an architecture for supporting emergency communications using an integrated access backhaul (IAB) in the heterogenous networks (HetNets). The macro base station (MBS) is connected to the wired backhaul, while the small cell base stations (SBSs) are wirelessly connected to the MBS using the IAB. The MBS is the IAB donor, while SBSs are the IAB nodes. As the IAB provides an economically viable solution for dense deployment in the wireless communication networks (WCNs), its use in public warning systems will serve as a robust solution during emergencies. Broadcasting the essential information with a wireless backhaul will involve the multi-hop networks to support minimum throughput requirements of the users within the respective small cell. A major benefit of using IAB is the spectral and infrastructure resource reuse for backhaul as well as the access network. An optimal split is essential for the available bandwidth, between the backhaul and access networks, for adequate system performance. Despite IAB being an attractive scheme, its implementation involves certain research challenges which have been stated in this paper.
Klinik Faz Çalışmaları Devam Eden RNA Tabanlı COVID-19 Aşı Adayları (2021)

The number of cases and disease-dependent deaths continue to increase worldwide due to the COVID-19 infection accepted as a global pandemic by the World Health Organization on March 11, 2020. Therefore, the antivirals used in treatment and vaccines that are the most effective weapons for protection remain the most popular topic on the agenda. There are a few conditions that might have an impact on the course of the pandemic, including the mutation of the virus and losing its ability to cause disease, generating herd immunity by reaching a critical rate of immunized people in the community due to the disease, and ensuring herd immunity through effective vaccination. Vaccine trials, which have started owing to the severity and urgency of the situation we are in, continue highly rapidly and effectively. According to the March 2, 2021 data of WHO, there are 258 vaccine trials, 76 of which are at the clinical phase, and 9 of the vaccine trials that are at the clinical phase are RNA-based vaccines. In our study, it was aimed to investigate RNA-based COVID-19 vaccine candidates and review their current data.
Albert Speer Journal de Spandau. Les confessions d’un pilier du IIIe Reich trad. par M. Brottier et D. Auclères, Paris, Pluriel, [1975] 2018, 632 p. (2019)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Molecular dissection of germline chromothripsis in a developmental context using patient-derived iPS cells (2017)

We demonstrate that a combination of patient-derived iPSC differentiation and trio-based molecular profiling is a powerful approach to improve the interpretation of pathogenic complex genomic rearrangements. Here we have applied this approach to identify misexpression of TWIST1, FOXP1, and DPYD as key contributors to the complex congenital phenotype resulting from germline chromothripsis rearrangements.
ChemInform Abstract: CATALYTIC HYDROGENOLYSIS. 2. DIRECT CLEAVAGE OF FUNCTIONAL GROUPS BY CATALYTIC HYDROGENOLYSIS (1980)

Abstract Die funktionellen Gruppen der Adamantane (I) bzw. (III) lassen sich hydrogenolytisch in hoher Reinheit und Ausb. abspalten.
ASSOCIATION STRUCTURES IN A W/O MICROEMULSION FROM FLUORESCENCE MEASUREMENTS (1990)

ABSTRACT Fluorescence probing was combined with light scattering measurements to determine association structures in W/O microemulsion. The results showed the microemulsions at low water content to contain aggregates with only one surfactant while association to inverse micelles took place first at higher water content. Adding different hydrocarbons showed a change of the association concentration with the nature of the hydrocarbon. An aromatic hydrocarbon significantly reduced the water concentration for association while aliphatic hydrocarbons showed less influence.
Extraction of large-area low-energy electron beams from a multi-dipolar plasma (2009)

International audience
3DOF Ultrasonic Motor with Two Piezoelectric Rings (2020)

A novel design of a multiple degrees of freedom (multi-DOF) piezoelectric ultrasonic motor (USM) is presented in the paper. The main idea of the motor design is to combine the magnetic sphere type rotor and two oppositely placed ring-shaped piezoelectric actuators into one mechanism. Such a structure increases impact force and allows rotation of the sphere with higher torque. The main purpose of USM development was to design a motor for attitude control systems used in small satellites. A permanent magnetic sphere with a magnetic dipole is used for orientation and positioning when the sphere is rotated to the desired position and the magnetic field synchronizes with the Earth's magnetic dipole. Also, the proposed motor can be installed and used for robotic systems, laser beam manipulation, etc. The system has a minimal number of components, small weight, and high reliability. Numerical simulation and experimental studies were used to verify the operating principles of the USM. Numerical simulation of a piezoelectric actuator was used to perform modal frequency and harmonic response analysis. Experimental studies were performed to measure both mechanical and electrical characteristics of the piezoelectric motor.
Magneto impedance of electroplated NiFeMo/Cu microwires for magnetic sensors (2007)

The field and frequency dependences of the magnetic permeability in soft magnetic electroplated FeNiMo/Cu microwires were studied by means of their magneto impedance response. We analysed the influence of electroplating parameters such as current density, electrolyte composition and the presence of a magnetic field. It was found that the introduction of Mo as a third non-magnetic component causes large changes in the film permeability, which are associated with compositional and morphological effects. The electrodeposition under an external magnetic field induces a unidirectional anisotropy with the appearance of a large Barkhausen effect.
Photonics bridges between turbulence and spin glass phenomena in the 2021 Nobel Prize in Physics (2022)

A photonic connection between turbulence and spin glasses has been recently established both theoretically and experimentally using a random fiber laser as a photonic platform. Besides unveiling this interplay, it links the works of two 2021 Nobel laureates in Physics.
Descending efferent connections of the sub-pallidal areas in the cat: projections to the lateral habenula (1995)

The descending efferent connections of the sub-pallidal areas to the lateral habenula were investigated in the cat using Phaseolus vulgaris leucoagglutinin (PHA-L) as an anterograde tracer. Several injections of PHA-L were made in various regions of the feline sub-pallidal regions. Subsequently, the distribution of anterogradely labelled fibres in the lateral habenula was charted. PHA-L injections into the rostral part of the sub-pallidal regions resulted in a limited number of labelled fibres in the lateral habenula, while PHA-L injections into the caudal regions of the sub-pallidum resulted in an extensive distribution of anterogradely labelled fibres in this area. Thus, the lateral habenula is an important output structure of the sub-pallidal areas in the cat.
Personalized glucose forecasting for type 2 diabetes using data assimilation (2017)

Type 2 diabetes leads to premature death and reduced quality of life for 8% of Americans. Nutrition management is critical to maintaining glycemic control, yet it is difficult to achieve due to the high individual differences in glycemic response to nutrition. Anticipating glycemic impact of different meals can be challenging not only for individuals with diabetes, but also for expert diabetes educators. Personalized computational models that can accurately forecast an impact of a given meal on an individual's blood glucose levels can serve as the engine for a new generation of decision support tools for individuals with diabetes. However, to be useful in practice, these computational engines need to generate accurate forecasts based on limited datasets consistent with typical self-monitoring practices of individuals with type 2 diabetes. This paper uses three forecasting machines: (i) data assimilation, a technique borrowed from atmospheric physics and engineering that uses Bayesian modeling to infuse data with human knowledge represented in a mechanistic model, to generate real-time, personalized, adaptable glucose forecasts; (ii) model averaging of data assimilation output; and (iii) dynamical Gaussian process model regression. The proposed data assimilation machine, the primary focus of the paper, uses a modified dual unscented Kalman filter to estimate states and parameters, personalizing the mechanistic models. Model selection is used to make a personalized model selection for the individual and their measurement characteristics. The data assimilation forecasts are empirically evaluated against actual postprandial glucose measurements captured by individuals with type 2 diabetes, and against predictions generated by experienced diabetes educators after reviewing a set of historical nutritional records and glucose measurements for the same individual. The evaluation suggests that the data assimilation forecasts compare well with specific glucose measurements and match or exceed in accuracy expert forecasts. We conclude by examining ways to present predictions as forecast-derived range quantities and evaluate the comparative advantages of these ranges.
A fuzzy reasoning method based on compensating operation and its application to fuzzy systems (2019)

In this paper, we present a new fuzzy reasoning method based on the compensating fuzzy reasoning (CFR). Its basicidea is to obtain a new fuzzy reasoning result by moving and deforming the consequent fuzzy set on the basis of themoving, deformation, and moving-deformation operations between the antecedent fuzzy set and observation information.Experimental results on real-world data sets show that proposed method significantly improve the accuracy and timeperformance of fuzzy neural network learning.
An Easy Access to 1-Azaspiropentane-2-carboxamides – The First Derivatives of a New Type of Amino Acids (1999)

Azaspiropentanecarboxamides 10 and 12 are formed with remarkable ease in two steps in a one-pot operation from methyl 2-chloro-2-cyclopropylideneacetate (4) by addition of a primary amine in tetrahydrofuran and subsequent treatment with sodium hydride/triethylamine in the presence of another equivalent of a primary amine or ammonia. Achievable yields of the amides 10, 12 were moderate to good (27–59%, 12–48%), while the corresponding esters 9 could only be obtained in poor yields (4–14%). The new α-amino acid amides are surprisingly stable, and they can be incorporated into small peptides as demonstrated with the preparation of the glycine 13e and the spirocyclopro-paneoxazoline derivative 14e.
Therapeutic effect of intra-articular injection of high molecular weight hyaluronic acid on osteoarthritis of the knee. (1982)

Intra-articular injections of high molecular hyaluronic acid (1% solution) were given at 1- or 2-week intervals to 43 patients with osteoarthritis of the knee. Of the 45 treated knees, 32 (71%) responded favorably. This therapy was effective if the osteoarthritis was of a grade less than moderate; it was not effective in cases with considerable effusion or in those with gross architectural changes. No serious side effects were encountered. We suggest that the beneficial effects of hyaluronic acid may be attributable to improved lubrication of the affected joint, to normalization of synovial fluid production by the action of hyaluronic acid on synovial tissue, and/or to the improvement of the intra-articular environment by the contribution of hyaluronic acid to the rebuilding of the barrier that protects the synovial membrane and articular surface.