gebhart/patrepeval huggingface dataset:
Liver Protein Profiling in Chronic Hepatitis C: Identification of Potential Predictive Markers for Interferon Therapy Outcome (2011)

The current anti-hepatitis C virus (HCV) therapy, based on pegylated-interferon alpha and ribavirin, has limited success rate and is accompanied by several side effects. The aim of this study was to identify protein profiles in pretreatment liver biopsies of HCV patients correlating with the outcome of antiviral therapy. Cytosolic or membrane/organelle-enriched protein extracts from liver biopsies of eight HCV patients were analyzed by two-dimensional fluorescence difference gel electrophoresis and mass spectrometry. Overall, this analysis identified 21 proteins whose expression levels correlate with therapy response. These factors are involved in interferon-mediated antiviral activity, stress response, and energy metabolism. Moreover, we found that post-translational modifications of dihydroxyacetone kinase were also associated with therapy outcome. Differential expression of the five best performing markers (STAT1, Mx1, DD4, DAK, and PD-ECGF) was confirmed by immunoblotting assays in an independent group of HCV patients. Finally, we showed that a prediction model based on the expression levels of these markers classifies responder and nonresponder patients with an accuracy of 85.7%. These results provide evidence that the analysis of pretreatment liver protein profiles is valuable for discriminating between responder and nonresponder HCV patients, and may contribute to reduce the number of nonresponder patients exposed to therapy-associated risks.
Three short cases for use in online introduction to computer information systems courses (2008)

Online courses are now commonplace at many universities, replacing correspondence (postal) based distance education methods. An important and widely used component of online courses are online forums. Forums encourage interaction between students (who may never meet face-to-face) and are a vital part of the virtual classroom experience. Literature suggests that distance learners require a great deal of interaction to overcome the feeling of isolation; the development of a virtual world (classroom) encourages students to participate in the learning process by exploring and playing with course materials; and promotes interactions between students and teachers that may not occur in a traditional classroom. In order to conduct a successful online forum it is necessary to have a collection of provocative discussion topics and a sound technique to implement them. This paper presents three short cases; Electronic Voting, the Digital Divide, and Internet Ethics, that have successfully been used in online courses along with pedagogy and implementation notes.
An Economic Comparison of Two Anaerobic Digestion Systems on Dairy Farms (2003)

Two dairy farms in New York State have recently installed anaerobic digesters as amethod to control odors and create value added by-products from their manure. The mass flow,nutrient flow and economics of these two systems will be compared. One farm chose a plug flowdigester with liquid solid separation. The separated liquid effluent is stored in an upright metalmanure storage structure and applied to the land by a custom operator. The solids are marketed offsite. The other farm chose a mixed digester incorporating food waste. They also separate the solids,but use them for bedding. The separated digested liquid effluent is stored in an earthen storagefacility and irrigated on the cropland. Both these systems save money when compared to traditionalmanure handling. However the amount of money saved per cow is quite different.
Polyamine-stimulation of arsenic-transformed keratinocytes (2019)

Tumor promotion is strongly associated with inflammation and increased polyamine levels. Our understanding of relevant mechanisms responsible for arsenic-induced cancer remains limited. Previous studies suggest that arsenic targets and dysregulates stem cell populations that remain dormant in the skin until promoted to be recruited out of the bulge stem cell region, thus giving rise to skin tumors. In this study, we explored a possible mechanism by which increased keratinocyte polyamine biosynthesis promotes tumorsphere formation and invasiveness of arsenic-transformed HaCaT keratinocytes (As-HaCaT). Unlike parental HaCaT cells, As-HaCaT cells were tumorigenic in athymic nude mice, and the CD45negative epithelial tumor cells had enriched expression of Toll-Like Receptor 4 (TLR4), CD34 and CXCR4 as did As-HaCaT tumorsphere cultures compared to As-HaCaT monolayer cultures. Ornithine decarboxylase (ODC) overexpressing keratinocytes (Ker/ODC) release increased levels of the alarmin high mobility group box 1 (HMGB1). Ker/ODC conditioned medium (CM) stimulated As-HaCaT but not parental HaCaT tumorsphere formation, and this was inhibited by glycyrrhizin, an inhibitor of HMGB1, and by TAK242, an inhibitor of the HMGB1 receptor TLR4. Compared to parental HaCaT cells, As-HaCaT cells demonstrated greater invasiveness across a Matrigel-coated filter using either fibroblast CM or SDF-1α as chemoattractants. Addition of Ker/ODC CM or HMGB1 dramatically increased As-HaCaT invasiveness. Glycyrrhizin and TAK242 inhibited this Ker/ODC CM-stimulated invasion of As-HaCaT cells but not HaCaT cells. These results show that polyamine-dependent release of HMGB1 promotes the expansion of stem cell-like subpopulations in arsenic-transformed keratinocytes while also increasing their invasiveness, suggesting that polyamines may be a potential therapeutic target for the prevention and treatment of arsenic-initiated skin cancers.
Active Interference Cancellation System. (1969)

The report reviews some of the principles and performance of an active Interference Cancellation System fabricated for UHF communication applications, and the techniques investigated and incorporated to increase the power handling capability of its signal controller. The system employs a synchronous cancellation technique for the suppression of receiver adjacent channel interference. The assigned task involved the investigation of techniques that would extend the power handling capability of the existing signal controller by employing more or alternate diodes, RM amplification, or alternate coupling devices to handle at least a +20 dBm interference signal at the receive antenna. Simultaneously with the above, the overall noise figure of the Interference Cancellation System will not degrade a receiver of -115 dBm sensitivity with a 50 kHz IF bandwidth. It was found that the best method for achieving the goal of +20 dBm was to employ alternate diodes and that higher power levels could be provided by employing more diodes and/or RF amplification. Still higher interference signal power levels can be cancelled by employing alternate coupling devices such as 10 or 20 dB summing couplers. The operational tradeoff for this option is that the apparent receiver sensitivity would decrease by 7 dB or 17 dB respectively. (Author)
MAGE-1 expression threshold for the lysis of melanoma cell lines by a specific cytotoxic T lymphocyte. (1997)

Human gene MAGE-1 codes for an antigen that is recognized on a melanoma by an autologous cytotoxic T lymphocyte (CTL). Because MAGE-1 is expressed on a significant proportion of tumours of various histological types and not on normal tissues, the encoded antigen may serve as a target for cancer immunotherapy. Evaluation of the expression of the gene by reverse transcription polymerase chain reaction (RT-PCR) in various tumour samples and tumour cell lines has suggested great variability in the level of expression. It was therefore important to evaluate the minimal level of expression required for lysis by CTL. We tested a number of melanoma cell lines by a quantitative RT-PCR assay to correlate their level of MAGE-1 expression and recognition by the relevant CTL clone. We found that only cell lines expressing more than 10% of the MAGE-1 messenger RNA (mRNA) level of reference cell line MZ2-MEL.3.0 (i.e. more than three mRNA molecules per cell) were lysed by the CTL or induced significant tumour necrosis factor release.
Expression, purification, crystallization and preliminary crystallographic analysis of a putativeClostridium difficilesurface protein Cwp19 (2011)

Cwp19 is a putatively surface-located protein from Clostridium difficile. A recombinant N-terminal protein (residues 27-401) lacking the signal peptide and the C-terminal cell-wall-binding repeats (PFam04122) was crystallized using the sitting-drop vapour-diffusion method and diffracted to 2 Å resolution. The crystal appeared to belong to the primitive monoclinic space group P2(1), with unit-cell parameters a=109.1, b=61.2, c=109.2 Å, β=111.85°, and is estimated to contain two molecules of Cwp19 per asymmetric unit.
Modified scalar potential solution for three-dimensional magnetostatic problems (1998)

A novel three-dimensional magnetostatic solution based on a modified scalar potential method has been developed. This method has significant advantages over the traditional total scalar, reduced scalar, or vector potential methods. The new method was successfully applied to a three-dimensional geometry of an iron core inductor and a permanent magnet motor. The results obtained are in close agreement with those obtained from traditional methods.
FE‐SEM observation of swelled seaweed using hydrophilic ionic liquid; 1‐butyl‐3‐methylimidazolium tetrafluoroborate (2012)

The method to observe the exact morphology of swelled seaweed as an example of biological material by field emission scanning electron microscopy (FE-SEM) with the aid of hydrophilic ionic liquid (IL); 1-butyl-3-methylimidazolium tetrafluoroborate is reported. Seaweed was first swelled in 3.5% NaCl solution and then treated with the IL and water mixture in 1:7 weight ratios and centrifuged to remove the excess IL solution. Thus treated seaweed maintained its morphology even at high magnification and did not show drying in the FE-SEM chamber. This observation technique might be useful for various kinds of biological materials to be observed under FE-SEM.
A Lifetime-Based Garbage Collector for LISP Systems on General-Purpose Computers. (1988)

Garbage collector performance in LISP systems on custom hardware has been substantially improved by the adoption of lifetime-based garbage collection techniques.To date, however, successful lifetime-based garbage collectors have required special-purpose hardware, or at least privileged access to data structures maintained by the virtual memory system.I present here a lifetime-based garbage collector requiring no special-purpose hardware or virtual memory system support, and discuss its performance.
SPY?: an innovative intra-operative imaging system to evaluate graft patency during off-pump coronary artery bypass grafting*1 (2004)

Off-pump coronary artery bypass grafting (CABG) has been rapidly increased, because of its less invasiveness with low complications. However, graft patency rate highly depends on the operators' capability due to technical difficulties. The SPY system, based on the fluorescence of indocyanine green, is an innovative device that permits validation of graft patency intra-operatively. Real time images of grafts are obtained with no need for catheterization, X-rays or iodine contrast medium. High-quality images could be obtained in all 290 grafts of 72 off-pump CABG cases (mean 4.0 grafts per patient). Four anastomoses (1.4%), including two proximal and two distal, were revised because of defects detected by SPY images. In one case, the SPY system revealed no blood flow in a radial sequential graft, although transit-time flow meter measurements showed a diastolic dominant pattern. SPY images provide critical information to surgeons to detect non-patent grafts, allowing them to be revised while the patient is still on the operating table. Using the SPY system, technical failures could be completely resolved during surgery. The use of the SPY system for intra-operative graft validation during off-pump CABG may become the gold standard for surgical management in the near future.
Mesoscale Wind Structure Revealed by Doppler Radar (1965)

Doppler wind soundings were taken in the lower 4.5 km of the atmosphere at 12 minute intervals during a seven hour period in a snowstorm over eastern Massachusetts. A time-height cross section of the wind revealed numerous small scale, short period changes in the wind structure. Initially there was a region of strong wind shear near 4 km, above the warm front zone. Periodic break-downs in the wind shear appeared to result in a downward transfer of momentum. In this way, winds at lower levels increased by as much as 10 m sec−1 within a half hour period. The series of three breakdowns occurred at about hourly intervals at successively lower levels, until by the end of the period the wind speed at all levels had increased by about a factor of two, and the wind shear zone was confined to the lowest few hundred meters. A time-height cross section of vertical motions indicated that each breakdown was preceded by a down-draft, followed by a turbulent region of successive updrafts and downdrafts of 2 to 4 m sec−1. These turbulent regions may be responsible for much of the short period change in structure of “uniform” precipitation. A comparative analysis, using hourly rawinsondes during a rainstorms with an analogous wind structure also revealed similar breakdowns, although the absence of resolution precluded delineation of the smaller scale turbulence which the Doppler observations so clearly reveal.
Raman and SERS Studies of Carbon Nanotubes (2002)

Since the discovery of carbon nanotubes, Raman Scattering Spectroscopy and transmission Electron Microscopy have been proved to be powerful for a detailed investigation of their properties. In TEM, a direct observation can be made, whereas Raman Scattering is used extensively to probe the different samples via their vibrational properties. In this paper, we report on recent results obtained in both single-walled carbon nanotubes (SWNTs), multiwalled-carbon nanotubes (MWNTs) and PMMA/nanotubes composites. In addition, in the case of SWNTs, we present studies carried out in Raman scattering when SERS (Surface Enhanced Raman Scattering) conditions are used. In particular, we put in evidence an increased state of disorder at the interface nanotubes/metallic support when the nanotube film thickness is decreased. Strong degradations can be observed primarily on metallic tubes with a concomitant formation of C 60 -like molecules. In the case of MWNTs, calculations of interactions between concentric tubes lead to the occurrence of low frequency vibrational modes, in good agreement with experiments.
소년과 제국: 19세기 중엽 이후의 모험소설과 학교소설 (2005)

The middle of the nineteenth century was a period of great change in the history of children`s literature. But children`s literature in that period was not an exception in confirming that it is a discursive field in which the image of the child is (re)produced and that the `child` is a constructed concept which carries the ideals of societies. The second half of the nineteenth century witnessed the emergence of new ideals according to the development of British Empire. Children`s literature in this period played an active role in creating and circulating these ideals. Adventure stories in the first half of the century share many characteristics with religious and didactic works and hold the image and values of middle class as an integral part. Ballantyne`s The Coral Island published in 1858 shows the shift of focus from the middle class to the empire, which parallers the change of main characters from children in family setting to boys. Ideas related to boys-justice, intrepidity, youth, freedom from corruption, etc.-are grafted onto the empire and it contributes to forming the image of the British Empire. Kingston`s The Three Midshipmen is a story of three young men`s feats of arms and celebrates loyalty, manliness and Englishness. The transformation of adventure stories after The Coral Island and the success of Hughes` Tom Brown`s Schooldays demonstrate the change of the Victorian ideal from `godliness and good learning` to `godliness and manliness`. The latter reflects the reorganization of the empire and new needs arising from it. Tom Brown`s Schooldays announces the coming of this new ideal and thereby is regarded as the precursor of school stories despite the facts that there were many other school stories before Hughes and that many school stories in the latter half of the century followed the example of Farrar`s Eric rather than Hughes` Tom Brown`s Scooldays. Though there emerged various sub-genres after the middle of the nineteenth century, they can be grouped together as the literature of the empire, against which child readers formed their identity and world view.
Optical path length fluctuations in the atmosphere (1984)

The effect of atmospheric fluctuations on measurements of distance has become increasingly important as laser interferometers become more widely used. The present study evaluates the precision with which dimensions can be monitored by interferometry involving optical path lengths in the open air under good atmospheric conditions. The size and time scale of optical path length fluctuations over distances of one meter, and correlations between fluctuations in nearby optical paths, are measured and analyzed.
OPTIMISATION ORIENTED MODELLING OF AIRBAG AND BELT (2000)

Today's Safety Restraint Systems are a compromise in that they are optimised for standard crashes and only take the most important crash characteristics into account when activated. This paper is about how to optimise the design parameters of the airbag and the belt for a large class of crashes. The curently used multibody models are far too complex for optimisation. The key-issue is to find a metamodel, i.e. an easy-to-calculate approximation for the time-consuming full analysis model. This metamodel then can be used in the iterative optimisation process. Here, the theory of design of experiments in combination with multiple regression, using the full model for the 'experiments', is applied to find the metamodel. The results show that the obtained model is accurate enough to be used for the optimisation of the design parameters. However, the metamodel is applicable only for one crash, i.e. all parameters in the full analysis model to characterise the crash and the occupant have to be fixed a priori. Further research enabling the metamodel to cover a large class of crashes is recommended. For the covering abstract see ITRD E109346.
Autologous Cultured Fibroblast Injection for Facial Contour Deformities (2007)

BACKGROUND Previous data indicate that injections of autologous fibroblasts increase collagen formation, accompanied by a concomitant increase in thickness and density of dermal collagen. OBJECTIVE The purpose of this study was to determine efficacy and side effects of autologous living fibroblast injections versus placebo in a randomized Phase III trial for the treatment of various facial contour defects. METHODS This was a double-blind, randomized comparison of injectable living autologous fibroblast cells and placebo for the treatment of facial contour defects (N=215). Live fibroblasts (20 million/mL) or placebo (the transport medium without living cells) were given as three doses administered at 1- to 2-week intervals. Efficacy evaluations were performed 1, 2, 4, 6, 9, and 12 months after the first injection. RESULTS Living fibroblasts produced statistically significantly greater improvements in dermal deformities and acne scars than did placebo. The difference between live fibroblast injections and placebo achieved statistical significance at 6 months (p<.0001). At 9- and 12-month follow-up, live fibroblast–treated patients continued to demonstrate benefit from treatment with response rates of 75.0 and 81.6%, respectively. No serious treatment-related adverse events were reported. CONCLUSIONS Our results indicate that autologous fibroblast injections can safely and effectively produce improvements in rhytids, acne scars, and other dermal defects continuing for at least 12 months after injection.
Crosslinking Treatment of EVA Film To Improve Flavor Preservation (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrosslinking Treatment of EVA Film To Improve Flavor PreservationMasaomi Fukamachi, Toshiro Matsui, Mitsuya Shimoda, and Yutaka OsajimaCite this: J. Agric. Food Chem. 1994, 42, 9, 1989–1992Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/jf00045a029https://doi.org/10.1021/jf00045a029research-articleACS PublicationsRequest reuse permissionsArticle Views135Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spatial-spectral modulating snapshot hyperspectral imager (2006)

Experimental results are presented for a computed tomography imaging spectrometer (CTIS) with imposed spatial-spectral modulation on the image scene. This modulation structure on the CTIS tomographic dispersion created substantial gains in spectral reconstruction resolution after standard iterative, nonlinear, inversion techniques were used. Modulation limits system ambiguities, so high-frequency spectral and low-frequency spatial scene data could be recovered. The results demonstrate how spatial modulation acts as a high-frequency spectral deconvolver for the snapshot hyperspectral imager technology.
Vancomycin Stress Response in a Sensitive and a Tolerant Strain ofStreptococcus pneumoniae (2005)

The vancomycin stress response was studied in Streptococcus pneumoniae strains T4 (TIGR4) and Tupelo. Vancomycin affected the expression of 175 genes, including genes encoding transport functions and enzymes involved in aminosugar metabolism. The two-component systems TCS03, TCS11, and CiaRH also responded to antibiotic treatment. We hypothesize that the three regulons are an important part of the bacterium's response to vancomycin stress.
Phylogenetic relatedness and host plant growth form influence gene expression of the polyphagous comma butterfly (Polygonia c-album) (2009)

Our data suggest a complex picture of gene expression in response to host plant feeding. While each plant requires a unique gene regulation in the caterpillar, both phylogenetic relatedness and host plant growth form appear to influence the expression profile of the polyphagous comma butterfly, in agreement with phylogenetic studies of host plant utilization in butterflies.