gebhart/patrepeval huggingface dataset:
Comparison of MEMS PZT Cantilevers Based on $d_{31}$ and $d_{33}$ Modes for Vibration Energy Harvesting (2012)

<i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">31</sub> and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">33</sub> mode microelectromechanical systems piezoelectric energy harvesters (PEHs) were fabricated and compared to investigate their output powers converted from vibration. Both types of devices have the same dimensions in a cantilever structure and aim to effectively couple vibration from ambient conditions. The resonant frequencies of the cantilevers are 243 Hz. Two types of devices were compared using mathematical equations based on an equivalent circuit model. The output power of the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">31</sub> mode PEH was 2.15 μW and 2.33 μW in experiment and modeling, respectively. The <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">33</sub> mode PEHs generated output power ranging between 0.62 and 1.71 μW when the width of the interdigital electrode (IDE) is ranging from 8 to 16 μm and finger spacing is varied from 4 to 16 μm. The output power of the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">33</sub> mode device strongly depends on the dimensions of IDE. The analysis of material constant and electrode design was conducted in conjunction with developing a mathematical equation. The result predicts that the output power of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">33</sub> mode PEH can be higher than that of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">31</sub> mode PEH when the finger width is reduced to 2 μm and finger spacing is between 8 and 20 μm.
Substrate Selection and Management Strategies for Aqueous EPD (2015)

Classical EPD has typically been conducted in organic solvent media. Many suitable solvents are volatile and highly flammable and this limits the industrial application of the technique on the basis of safety alone. Aqueous EPD may be seen as a safer method, but issues relating to electrolysis and surface energy phenomena become prominent and can create interferences and variability unless the substrate type and its preparation are compatible with the aqueous EPD chemistry and its deposition method. As EPD layers become thinner, factors such as substrate surface structure and wettability become more critical. Industrial processes utilising some principles of EPD for applying paint from water-based preparations are well established in the metal finishing sector. Consequently there is a significant body of practical experience available from this sector that can be of use in translating classical EPD from a solvent to an aqueous technique while avoiding interferences inherent in the use of water as the deposition medium. In this paper, substrate selection is discussed in relation to the electrolyte content of the system where phenomena such as dissolution and micro-arcing can occur. The initial wetting of the substrate must be considered prior to applying voltage. Surface preparation techniques and the methods of introducing the substrate into the EPD dispersion all can have an impact on the final result. Note: This paper is based on the authors’ personal and practical experience of industrial electrophoretic painting over more than 40 years. Only metal substrates are discussed because these have been almost exclusive in this sector during that time. Non-metal substrates such as conductive plastics, graphite and carbon fibre have also been coated with electrophoretic paints but this is not yet at any significant scale and so no general principles have been established
Cancer-Immunity Cycle and Therapeutic Interventions- Opportunities for Including Pet Dogs With Cancer (2021)

The tumor-immune interplay represents a dynamic series of events executed by cellular and soluble participants that either promote or inhibit successful tumor formation and growth. Throughout a tumor's development and progression, the host organism's immune system reacts by generating anti-cancer defenses through various incremental and combinatorial mechanisms, and this reactive orchestration is termed the cancer-immunity cycle. Success or failure of the cancer-immunity cycle dictates the fate of both host and tumor as winner or loser. Insights into how the tumor and host immune system continuously adapt to each other throughout the lifecycle of the tumor is necessary to rationally develop new effective immunotherapies. Additionally, the evolving nature of the cancer-immunity cycle necessitates therapeutic agility, requiring real-time serial assessment of immunobiologic markers that permits tailoring of therapies to the everchanging tumor immune microenvironment. In order to accelerate advances in the field of immuno-oncology, this review summarizes the steps comprising the cancer-immunity cycle, and underscores key breakpoints in the cycle that either favor cancer regression or progression, as well as shaping of the tumor microenvironment and associated immune phenotypes. Furthermore, specific large animal models of spontaneous cancers that are deemed immunogenic will be reviewed and proposed as unique resources for validating investigational immunotherapeutic protocols that are informed by the cancer-immunity cycle. Collectively, this review will provide a progressive look into the dynamic interplay between tumor and host immune responses and raise awareness for how large animal models can be included for developing combinatorial and sequenced immunotherapies to maximizing favorable treatment outcomes.
Development of polyarthritis after insertion of silicone breast implants followed by remission after implant removal in 2 HLA-identical sisters bearing rheumatoid arthritis susceptibility genes. (1997)

We describe 2 HLA-identical sisters who both received silicone breast implants and subsequently developed polyarticular arthritis and neurologic symptoms. In both patients, HLA typing revealed 3 alleles typically associated with rheumatic diseases: HLA-DRB1*0405 and HLA-DQB1*0302 (associated with RA), and HLA-DRB4*01 (associated with mixed connective tissue disease and autoimmune reactions in patients with silicone breast implants. After removal of the implants, rheumatic as well as neurologic symptoms improved dramatically in both patients. One patient achieved complete remission. The other patient, who initially had more progressive disease, retained mild residual symptoms, but had significant improvement in radiological erosions. We believe that our cases support the theories that silicone may act as a triggering factor in genetically susceptible individuals, and that silicone may represent an adjuvant for the development of autoimmune disease. We discuss the possibility that a manifested spectrum of symptoms after silicone exposure might be more specific for a patient's genetic background than unique for silicone.
Development and evaluation of paclitaxel nanoemulsion for cancer therapy (2019)

Tocosol™ is a tocopherol-based paclitaxel (PTX) nanoemulsion consisting of α-tocopherol (α-T) isomer of vitamin E as a solubilizer and vitamin E TPGS as the primary emulsifier. Despite its positive attributes in early clinical studies, it failed the pivotal phase III clinical trials. The long-term goal of this work was to reformulate Tocosol™. In this study, Tocosol™ formulation was optimized by replacing the α-T isomer with the more pharmacological active isomer γ-tocotrienol (γ-T<sub>3</sub>), and the surfactant vitamin E TPGS was replaced with in-house designed PEGylated γ-T<sub>3</sub> surfactant. The reformulated paclitaxel γ-T<sub>3</sub>/PEGylated γ-T<sub>3</sub> -based nanoemulsion was significantly more active against pancreatic tumor cell lines than α-T/Vitamin E TPGS based formulation (IC<sub>50</sub> = 0.5 μM and 1.1 μM, respectively). Furthermore, the reformulated product showed an average size of 220 ± 6 nm with surface charge equal to -42 ± 2 mV. The optimized product was physically and chemically stable over 6 months per ICH storage condition guidelines.
Spindlin1 represses HBV transcription in HepAD38 cells. (2015)

&lt;p&gt;(&lt;b&gt;A&lt;/b&gt;) HepAD38 cells cultured without tetracycline were transduced with an empty lentiviral vector (Ctrl) or a lentiviral vector encoding His-Myc-Spindlin1 (Myc-Spin1). Cells were then harvested 48 h after transduction for total RNA extraction and HBV transcription was analyzed by RT-qPCR (left graph). Transcript level in cells transduced with the empty lentiviral vector was set to 1. &lt;i&gt;P&lt;/i&gt; values were determined by Wilcoxon test (**, &lt;i&gt;P&lt;/i&gt; = 0.007). Error bars represent SD of eight independent experiments. Alternatively, cells were harvested 72 h after transduction and capsid-associated DNA was extracted. The replication intermediates were then analyzed by southern blot. RC: relaxed circular DNA, SS: single-stranded DNA, RI: replication intermediates. The relative intensities of RC DNA (1) and SS DNA (2) were quantified. The results are presented on the right graphs. The intensity in the control condition was set at 1. (&lt;b&gt;B&lt;/b&gt;) Spindlin1 does not affect HBV RNA stability. HepAD38 cultured without tetracycline were transduced as in (A). After 48 h, the cells were treated with actinomycin D (5 µg/ml) that blocks polymerase II. Cells were collected at the indicated times after treatment and total RNA was prepared. HBV RNAs were then quantified by RT-qPCR. The relative level of HBV transcription was normalized with Roth2 gene. The amount of RNA at time zero was set at 100%. (&lt;b&gt;C&lt;/b&gt;) Spindlin1 modulates the rate of HBV transcription. Nuclear run-on assays were performed on isolated nuclei from HepaAD38 cells transduced as in (A). Transcripts generated during run-on were purified using anti-BrdU beads and HBV RNAs were quantified by RT-qPCR. Transcript level in cells transduced with the empty lentiviral vector was set to 1. Error bars represent SD of three independent experiments. The expression of His-Myc-Spin1 was analyzed by immunoblot with anti-Myc antibodies. Tubulin was used as loading control (Right panel). (&lt;b&gt;D&lt;/b&gt;) Spindlin1 knock-down increases HBV transcription. HepAD38 cells were transduced with a lentiviral vector allowing the expression of a control shRNA (shCtrl) or shRNAs directed against Spindlin1 (shSpindlin1). After selection with puromycin (4 µg/ml), cells stably expressing shCtrl or shSpin1 were transfected with 25 nM of control siRNA (siCtrl) or directed against Spindlin1 (siSpin1) respectively. 48 h post-transfection, cells were harvested for total RNA extraction and, HBV (left panel) or pre-rRNA transcription (right panel) were analyzed by RT-qPCR. Spindlin1 expression in shCtrl+siCtrl or shSpin1+siSpin1 HepAD38 cells was analyzed by RT-qPCR (bottom left graph) and by immunoblotting with anti-Spin1 antibodies. Anti-tubulin immunostaining was used as loading control (bottom right panel). Transcript level in shCtrl HepAD38 cells transfected with siCtrl was set to 1. &lt;i&gt;P&lt;/i&gt; values were determined by Wilcoxon test (*, &lt;i&gt;P&lt;/i&gt;&lt;0.05). Error bars represent SD of six independent experiments.&lt;/p&gt;
Estimation of the plasma concentration and course of action of phentolamine based on its inhibitory effect on adrenaline‐induced platelet aggregation. (1978)

I Orally administered phentolamine retards the first phase of adrenaline-induced platelet aggregation. The extent to which aggregation was inhibited was compared in blood samples from six healthy volunteers treated with phentolamine and samples to which various concentrations of the drug were added in vitro. 2 These experiments permitted conclusions to be drawn concerning the magnitude and time-course of the plasma concentrations reached after the administration of phentolamine. A dose of 40 mg of the standard formulation (SF) produced a maximum effect after 30 min corresponding to that of a phentolamine concentration of approximately 12 x 10-8 M (-34 ng/ml). After 3 h about one-third of the maximum effect persisted, and after 6 h only a slight degree of activity was still detectable. The slow-release formulation (SR) (100 and 200 mg) had a rapid onset of action (1 h); the maximum effect was observed after 4 h, corresponding to an estimated plasma concentration of phentolamine of 11 and 42 ng/ml respectively, and the duration of action was well in excess of 12 h. 3 The time-course of the increase in heart rate and the increase in myocardial contractility (as determined from the pre-ejection period) was largely consistent with the calculated time-course of the plasma concentrations: A dose of 40 mg SF produced its maximum effect after 30-60 min and had a duration of action of 3 h. The maximum effect of the SR formulation was reached after 4 h, and the duration of action was more than 10 h.
Weak-value thermostat with 02 mK precision (2012)

A new laser-based thermostat sensitive to 0.2 mK at room temperature is reported. The method utilizes a fluid-filled prism and interferometric weak-value amplification to sense nanoradian deviations of a laser beam: due to the high thermo-optic coefficient of the fluid (colorless fluorocarbon), the deviation angle through the prism is sensitive to temperature. We estimate the daily stability of our device to be 0.2 mK, which is limited by drifts in the apparatus, and the narrow 20 mK capture range is the price paid for the weak measurement.
X-ray diffraction analysis of a crystal of HscA fromEscherichia coli (2005)

HscA is a constitutively expressed Hsp70 that interacts with the iron-sulfur cluster assembly protein IscU. Crystals of a truncated form of HscA (52 kDa; residues 17-505) grown in the presence of an IscU-recognition peptide, WELPPVKI, have been obtained by hanging-drop vapor diffusion using ammonium sulfate as the precipitant. A complete native X-ray diffraction data set was collected from a single crystal at 100 K to a resolution of 2.9 A. The crystal belongs to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 158.35, b = 166.15, c = 168.26 A, and contains six molecules per asymmetric unit. Phases were determined by molecular replacement using the nucleotide-binding domain from DnaK and the substrate-binding domain from HscA as models. This is the first reported crystallization of an Hsp70 containing both nucleotide- and substrate-binding domains.
Spontaneous infarction of pleomorphic adenoma of the parotid gland: A case report (2020)

Infarction after the fine-needle aspiration (FNA) procedure is a well-recognized phenomenon of salivary gland lesions. Though extremely rare, spontaneous infarction without previous FNA can occur in pleomorphic adenoma (PA). The present report describes a fourth cytological case of spontaneous infarction of PA of the parotid gland using immunocytochemical analysis, to the best of our knowledge, for the first time. A 57-year-old Japanese female presented with persistent swelling of the right neck region. Physical examination revealed a tumour in the right parotid gland, and FNA examination of the tumour was performed following surgical resection. The Papanicolaou smear demonstrated the presence of fully necrotic cell clusters of varying sizes in a necrotic background. Only a few viable cell clusters were observed. These cells were polygonal to spindle-shaped, and exhibited large round to oval nuclei with a conspicuous nucleoli. Although nuclear pleomorphism was noted, the nuclear chromatin was fine. No neoplastic myoepithelial cells were observed. Therefore, it was suspected that these cells were malignant. Immunocytochemical analysis indicated that these atypical cells were positive for p40. Histopathological examination of the resected parotid gland tumour revealed infarcted PA. Our study revealed that the presence of atypical squamous metaplastic cells in a necrotic background was a characteristic cytological feature of infarcted PA, and that these atypical squamous cells can have large nuclei with conspicuous nucleoli and exhibit pleomorphism. Although cytological diagnosis of infarcted PA is difficult, pathologists and cytopathologists must consider the presence of atypical metaplastic squamous cells in benign salivary gland tumours, including infarcted PA.
Faecal calprotectin and lactoferrin are reliable surrogate markers of endoscopic response during Crohn's disease treatment (2009)

The faecal neutrophil-derived proteins calprotectin and lactoferrin are reliable surrogate markers of mucosal improvement. Endoscopic responders achieved normalization of faecal biomarkers, whereas in the majority of endoscopic non-responders these markers remained abnormal.
A one-pot trifunctionalization of olefins with benzeneseleninic and trifluoroacetic anhydrides using a commonly undesirable side reaction as a key step (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA one-pot trifunctionalization of olefins with benzeneseleninic and trifluoroacetic anhydrides using a commonly undesirable side reaction as a key stepAndrei G. Kutateladze, John L. Kice, Tatiana G. Kutateladze, and Nikolai S. ZefirovCite this: J. Org. Chem. 1993, 58, 5, 995–996Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/jo00057a005https://doi.org/10.1021/jo00057a005research-articleACS PublicationsRequest reuse permissionsArticle Views178Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A Design of Underwater Acoustic Responder Based on Spread-Spectrum Communication (2012)

In order to satisfy the requirement of the underwater acoustic positioning system for offshore oil exploration, a design idea for an underwater acoustic responder which used on USBL positioning system was proposed. The hardware adopted MSP430F5438 as the core of controlling and the digital signal processor TMS320VC5509A for computing, and made a detailed analysis for the low-power hardware design. Gold sequence direct sequence spread-spectrum was used on communication system, while modulation was PSK. An appropriate spread-spectrum synchronization mode was presented for the system. MATLAB-based simulation and experiments show that the responder is working reliably and supporting multi-user communication. Meanwhile, the standby quiescent current is less than 2 mA.
Primary Bilateral Adrenal Lymphoma (1997)

We report a case of primary bilateral adrenal non-Hodgkins lymphoma (NHL), with hypercalcemia at the time of presentation. Medical literature review showed that this is an extremely rare site for lymphoma, but presents a distinct clinical entity with many features that differ from NHL overall, extranodal NHL, and NHL in other endocrine organs. The diagnosis is frequently not suspected antemortem, and long delays between the onset of symptoms and the diagnosis are frequent. Adrenal insufficiency is also common, and may be a lethal complication of these tumors. Response to therapy and survival are extremely poor.
Biological functions of CDK5 and potential CDK5 targeted clinical treatments (2017)

Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit. For most CDKs, activation by a cyclin occurs through association and phosphorylation of the CDK's T-loop. CDK5 is unusual because it is not typically activated upon binding with a cyclin and does not require T-loop phosphorylation for activation, even though it has high amino acid sequence homology with other CDKs. While it was previously thought that CDK5 only interacted with p35 or p39 and their cleaved counterparts, Recent evidence suggests that CDK5 can interact with certain cylins, amongst other proteins, which modulate CDK5 activity levels. This review discusses recent findings of molecular interactions that regulate CDK5 activity and CDK5 associated pathways that are implicated in various diseases. Also covered herein is the growing body of evidence for CDK5 in contributing to the onset and progression of tumorigenesis.
Temporal Logics of Agency (2010)

Time is the grand stage where human activities take place (rational or otherwise). And the view of a branching temporal universe, or tree of possible events, with our actual history linearly advancing through it, is a widely shared cultural idea, not confined to Academia (cf. Borges brilliant 1941 essay El Jardn de senderos que se bifurcan). Even though logic is often considered a study of timeless propositions, temporal languages and logics over tree structures have a long tradition. Philosophers have studied temporal structure and temporal reasoning since the 1950s, from the 'tense logic Moreover, starting from 1970s, computer scientists have joined in, and developed many further flavours of temporal logic, with major strands such as Pnueli on program correctness (Manna and Pnueli 1991), Emerson and Clarke on process specification and verification (Emerson and Clarke 1980, 1982), Reiter on the situation calculus in AI (Reiter 2001), and Thomas on the automata-theoretic foundations of computing In addition, the pure first-and second-order logic of tree-like structures, starting from Rabin's classic decidability result Grdel et al. (2002)). The chapter by Hodkinson and Reynolds on 'Temporal Logic' in the Handbook of Modal Logic (Hodkinson and Reynolds 2006) brings together many of these trends in one mathematical narrative. But the field of reasoning in, and about, time can be mapped out in many further ways: Van Benthems chapter 'Temporal Logic' in the