gebhart/patrepeval huggingface dataset:
Analysis of laser transformation hardening process of hypoeutectoid steel. 1st Report, Formulation and computer model for coupled analysis between temperature field and structural changes. (1991)

Coupling effects between the temperature field and the structural changes are considered in the analysis of the laser transformation hardening process.
Gaussian-sum cubature Kalman smoothers for bearings-only tracking (2014)

In this paper, a fixed-lag and a fixed-interval Gaussian-sum cubature Kalman smoother are proposed for the bearings-only tracking problem. The smoothers are of the forward-backward type and they utilise the Gaussian-sum cubature Kalman filter with improved robustness presented by the authors in [1]. Simulation results show that both the fixed-lag and fixed-interval smoothers exhibit improved accuracy over their filtering counterpart and outperform other existing smoothers of the same type for this problem, with the root-mean-square error overlapping the Cramér-Rao lower bound.
Biosensor based on Prussian blue nanocubes/reduced graphene oxide nanocomposite for detection of organophosphorus pesticides (2012)

We demonstrate a facile procedure to efficiently prepare Prussian blue nanocubes/reduced graphene oxide (PBNCs/rGO) nanocomposite by directly mixing Fe(3+) and [Fe(CN)(6)]((3)-) in the presence of GO in polyethyleneimine aqueous solution, resulting in a novel acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs). The obtained nanocomposite was characterized by X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM) and energy-dispersive X-ray (EDX) microanalysis. It was clearly observed that the nanosheet has been decorated with cubic PB nanoparticles and nearly all the nanoparticles are distributed uniformly only on the surface of the reduced GO. No isolated PB nanoparticles were observed, indicating the strong interaction between PB nanocubes and the reduced GO and the formation of PBNCs/rGO nanocomposite. The obtained PBNCs/rGO based AChE biosensor make the peak potential shift negatively to 220 mV. The over-potential decreases ∼460 mV compared to that on a bare electrode, suggesting that PBNCs/rGO has a high electrocatalytic activity towards the oxidation of thiocholine. The AChE biosensor shows rapid response and high sensitivity for detection of monocrotophos with a linear range from 1.0 to 600 ng mL(-1) and a detection limit of 0.1 ng mL(-1). These results suggest that the PBNCs/rGO hybrids nanocomposite exhibited high electrocatalytic activity towards the oxidation of thiocholine, which lead to the sensitive detection of OP pesticides.
The Shall Design Test Development Model for Hardware Systems (1997)

The object of this paper is to present a development model which helps to provide a clearer organizational structure for new designs by linking the separate aspects of a development process (analysis, design, testing). Particular emphasis is placed on the interrelation between problem analysis (“Shall Model”) and implementation (“Design Model”), and also between problem analysis (“Shall Model”) and testing procedure (“Test Model”). The consequences of redesigns as well as the integration of reusable designs in new designs are also discussed with reference to use of the Sdevelopment model.
S-palmitoylation represents a novel mechanism regulating the mitochondrial targeting of BAX and initiation of apoptosis (2014)

The intrinsic pathway of apoptotic cell death is mainly mediated by the BCL-2-associated X (BAX) protein through permeabilization of the mitochondrial outer membrane (MOM) and the concomitant release of cytochrome c into the cytosol. In healthy, non-apoptotic cells, BAX is predominantly localized in the cytosol and exhibits a dynamic shuttle cycle between the cytosol and the mitochondria. Thus, the initial association with mitochondria represents a critical regulatory step enabling BAX to insert into MOMs, promoting the release of cytochrome c and ultimately resulting in apoptosis. However, the molecular mode of how BAX associates with MOMs and whether a cellular regulatory mechanism governs this process is poorly understood. Here we show that in both primary tissues and cultured cells, the association with MOMs and the proapoptotic action of BAX is controlled by its S-palmitoylation at Cys-126. A lack of BAX palmitoylation reduced BAX mitochondrial translocation, BAX oligomerization, caspase activity and apoptosis. Furthermore, ectopic expression of specific palmitoyl transferases in cultured healthy cells increases BAX S-palmitoylation and accelerates apoptosis, whereas malignant tumor cells show reduced BAX S-palmitoylation consistent with their reduced BAX-mediated proapoptotic activity. Our findings suggest that S-palmitoylation of BAX at Cys126 is a key regulatory process of BAX-mediated apoptosis.
CXCL10‐induced cell death in neurons: role of calcium dysregulation (2006)

Chemokines play a key role in the regulation of central nervous system disease. CXCL10 over-expression has been observed in several neurodegenerative diseases, including multiple sclerosis, Alzheimer's disease and HIV-associated dementia. More recent studies by others and us have shown that CXCL10 elicits apoptosis in fetal neurons. The mechanism of CXCL10-mediated neurotoxicity, however, remains unclear. In this study, we provide evidence for the direct role of Ca(2+) dysregulation in CXCL10-mediated apoptosis. We demonstrate that treatment of fetal neuronal cultures with exogenous CXCL10 produced elevations in intracellular Ca(2+) and that this effect was modulated via the binding of CXCL10 to its cognate receptor, CXCR3. We further explored the association of intracellular Ca(2+) elevations with the caspases that are involved in CXC10-induced neuronal apoptosis. Our data showed that increased Ca(2+), which is available for uptake by the mitochondria, is associated with membrane permeabilization and cytochrome c release from this compartment. The released cytochrome c then activates the initiator active caspase-9. This initiator caspase sequentially activates the effector caspase-3, ultimately leading to apoptosis. This study identifies the temporal signaling cascade involved in CXCL10-mediated neuronal apoptosis and provides putative targets for pharmaceutical intervention of neurological disorders associated with CXCL10 up-regulation.
A Modeling of Twisted and Coiled Polymer Artificial Muscles Based on Elastic Rod Theory (2020)

Twisted and coiled polymer (TCP) can generate large stroke and output high power density, making it a promising artificial muscle. Thermally induced muscles fabricated from nylon or other polymer fibers can be used in robotic, biomedical devices, and energy-harvesting equipment. While fibers with different shapes and materials have different optimal process parameters. Understanding mechanisms of TCP forming and the impact of process parameters is critical to explore stronger, more powerful artificial muscles. In this paper, an elastic-rod-theory-based model was established for capturing the quantitative relationship between tensile actuation and fabrication load. Further experimental results agree with model calculation and TCP muscles used in our research reaches maximum stroke of 52.6%, strain up to 9.8 MPa, and power density of 211.89 J/kg.
Hydrogen bond strengths and acidities of hydroxyl groups on silica–alumina surfaces and in molecules in solution (1974)

The properties of hydroxyl groups on mixed silica–alumina gels (0–50 % Al2O3) have been studied by adsorbing weak H bond accepting molecules onto the gels and recording the OH stretching infrared band.Additional measurements on silica gel and compilation of numerous literature data have shown that frequency shift measurements, or series of Δtext-decoration:overlinevOH measurements condensed into BHW (Bellamy, Hallam and Williams) slopes, provide a reliable estimate of the OH acidity. The resulting scale is independent of the atom to which the hydroxyl is attached; it may be used for surfaces of solids as well as for solutions.The results obtained for silica–alumina show that two distinct populations of hydroxyl groups are present. Hydroxyl groups of type 1 are identical with those present on the surface of silica. The spectra show the presence of hydroxyl groups of a second type, the proportion of which increases as the Al content of the gel rises; their acidity corresponds to a pKa between –4 and –8 and they are presumably the sites responsible for the protonation observed upon adsorption of pyridine or ammonia.
Synthesis and Characterization of New Xanthene Derivatives, and Their Electrochemical Study (2015)

Abstract This work investigated the synthesis of biphenyl‐3,3′,4,4′‐tetracarboxylic dianhydride and benzophenone‐3,3′,4,4′‐tetracarboxylic dianhydride derivatives ( 3a – e and 6a – e ) with different substituted phenols via Friedel‐Crafts acylation reaction in the presence of dilute sulfuric acid. Dianhydride derivatives with 3‐N,N′‐dimethylamino phenol ( 3d and 6d ) and resorcinol ( 3e and 6e ) have been found to be highly fluorescent. The structures of all newly synthesized compounds were confirmed by the chromatographic, spectral and elemental data. Electrochemical study was done to determine to band gap energy, LUMO and HOMO levels energy. Band gap and LUMO energy levels were found to be lowest in xanthene derivatives substituted with 3‐N,N′‐dimethylamino group having value 2.24 and 4.85 eV respectively.
Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice (1997)

The functional role of interleukin (IL)-4 in the development of airway hyperresponsiveness (AHR) and pulmonary eosinophilia in response to sensitization and challenge of mice with sheep red blood cells (SRBC) was examined. Control- and SRBC-sensitized A/J mice were treated with an antibody to the murine IL-4 receptor (anti-IL-4R) 3 days before intratracheal challenge with the antigen or vehicle only. Blockade of IL-4R significantly reduced antigen-induced AHR and prevented increases in goblet cells and bronchoalveolar lavage (BAL) eosinophils. Treatment with anti-IL-4R did not affect antigen-induced increases in lung mRNA and BAL protein levels of IL-5 and interferon-gamma or IL-4 mRNA but did significantly increase IL-4 protein levels. Antigen-induced AHR was not reduced by treatment with antibodies to the adhesion molecules, vascular cell adhesion molecule-1 and very late activation antigen-4. Administration of IL-4 over a 7-day period did not increase airway reactivity or induce any changes in BAL cell numbers in naive mice. These results demonstrate that IL-4 is necessary for in vivo development of antigen-induced AHR, goblet cell metaplasia, and pulmonary eosinophilia.
Measuring Tie Strength (1984)

Little attention has been given to the measurement of the concept of tie strength.Using survey data on friendship ties, we apply multiple indicator techniques to construct and validate measures of tie strength.We conclude that: (1) there may be two distinct aspects of tie strength, having to do with the time spent in a relationship and the depth of the relationship; (2) a measure of "closeness" or intensity is the best indicator of strength; (3) there are difficulties with frequency and duration of contact as indicators of strength; (4) predictors of strength (e.g., kin- ship, neighboring) are not especially strongly related to the concept; and (5) the constructed measures of strength, particularly the one of "time spent," are valid in that they are related to predictor variables in anticipated directions.
Predicting Chronic Homelessness: The Importance of Comparing Algorithms using Client Histories (2021)

This paper investigates how to best compare algorithms for predicting chronic homelessness for the purpose of identifying good candidates for housing programs. Predictive methods can rapidly refer potentially chronic shelter users to housing but also sometimes incorrectly identify individuals who will not become chronic (false positives). We use shelter access histories to demonstrate that these false positives are often still good candidates for housing. Using this approach, we compare a simple threshold method for predicting chronic homelessness to the more complex logistic regression and neural network algorithms. While traditional binary classification performance metrics show that the machine learning algorithms perform better than the threshold technique, an examination of the shelter access histories of the cohorts identified by the three algorithms show that they select groups with very similar characteristics. This has important implications for resource constrained not-for-profit organizations since the threshold technique can be implemented using much simpler information technology infrastructure than the machine learning algorithms.
Mapping spatio‐temporal activation of Notch signaling during neurogenesis and gliogenesis in the developing mouse brain (2004)

Notch1 plays various important roles including the maintenance of the stem cell state as well as the promotion of glial fates in mammalian CNS development. However, because of the very low amount of the activated form of Notch1 present in vivo, its precise activation pattern has remained unknown. In this study, we mapped the active state of this signaling pathway in situ in the developing mouse brain using a specific antibody that recognizes the processed form of the intracellular domain of Notch1 cleaved by presenilin/gamma-secretase activity. By using this antibody, active state of Notch1 came to be detectable with a higher sensitivity than using conventional antibody against Notch1. We found that activated Notch1 was mainly detected in the nuclei of a subpopulation of radial glial cells, the majority of proliferating precursor cells in the ventricular zone (VZ). However, Notch1 activation was not detected in neuronal precursor cells positive for neuronal basic helix-loop-helix proteins or in differentiating neurons in the embryonic forebrain. Interestingly, we found that Notch1 was transiently activated in the astrocytic lineage during perinatal CNS development. Taken together, the present method has enabled us to determine the timing, gradients, and boundaries of the activation of Notch signaling.
FUNDAMENTAL CHARACTERISTICS OF SWIRLING JETS IN CYLINDRICAL VESSEL(Swirling Flow and Separation) (2005)

When gas was injected into a cylindrical bath through a centered bottom nozzle, a bubbling jet was formed above the nozzle. It swirled around the bath axis under a certain condition. The liquid in the bath also swirled in phase with the swirl motion of the bubbling jet. Such a swirl motion of the bubbling jet has a high mixing ability. A similar swirl motion appeared when a liquid or a mixture of gas and liquid was injected in a cylindrical bath. The occurrence conditions of these swirling jets were experimentally investigated in addition to their basic characteristics such as the period and amplitude.
A study of verbal and spatial information processing using event‐related potentials and positron emission tomography (1997)

The activated cerebral regions and the timing of information processing in the hemispheres was investigated using event-related potentials (ERP) and regional cerebral blood flow (rCBF) as the neurophysiological indicators. Seven men and one woman (age 19-27 years) were asked to categorize two-syllable Japanese nouns (verbal condition) and to judge the difference between pairs of rectangles (spatial condition), both tests presented on a monochrome display. In the electroencephalogram (EEG) session, EEG were recorded from 16 electrode sites, with linked earlobe electrodes as reference. In the positron emission tomography (PET) session, rCBF were measured by the 15O-labeled H2O bolus injection method. Regions of interest were the frontal, temporal, parietal, occipital and central lobes, and the entire cerebral hemispheres. When the subtracted voltages of the ERP in homologous scalp sites were compared for the verbal and spatial conditions, the significant differences were at F7.F8 and T5.T6 (the 10-20 system). The latencies of the differences at T5.T6 were around 200, 250 and 320 ms. A significant difference in rCBF between the verbal and spatial conditions was found only in the temporal region. It was concluded that early processing of information, that is, registration and simple recognition, may be performed mainly in the left temporal lobe for verbal information and in the right for spatial information.
ChemInform Abstract: Optically Active Antifungal Azoles. Part 12. Synthesis and Antifungal Activity of the Water‐Soluble Prodrugs of 1‐[(1R,2R)‐2‐(2,4‐Difluorophenyl)‐2‐hydroxy‐1‐methyl‐3‐ (1H‐1,2,4‐triazol‐1‐yl)propyl]‐3‐ [4‐(1H‐1‐tetrazolyl)phenyl]‐2‐imidazolidinone. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Receptor-Mediated Host Cell Preference of a Bat-Derived Filovirus, Lloviu Virus (2020)

Lloviu virus (LLOV), a bat-derived filovirus that is phylogenetically distinct from human pathogenic filoviruses such as Ebola virus (EBOV) and Marburg virus (MARV), was discovered in Europe. However, since infectious LLOV has never been isolated, the biological properties of this virus remain poorly understood. We found that vesicular stomatitis virus (VSV) pseudotyped with the glycoprotein (GP) of LLOV (VSV-LLOV) showed higher infectivity in one bat (<i>Miniopterus</i> sp.)-derived cell line than in the other bat-derived cell lines tested, which was distinct from the tropism of VSV pseudotyped with EBOV (VSV-EBOV) and MARV GPs. We then focused on the interaction between GP and Niemann-Pick C1 (NPC1) protein, one of the cellular receptors of filoviruses. We introduced the <i>Miniopterus</i> bat and human NPC1 genes into NPC1-knockout Vero E6 cells and their susceptibilities to the viruses were compared. The cell line expressing the bat NPC1 showed higher susceptibility to VSV-LLOV than that expressing human NPC1, whereas the opposite preference was seen for VSV-EBOV. Using a site-directed mutagenesis approach, amino acid residues involved in the differential tropism were identified in the NPC1 and GP molecules. Our results suggest that the interaction between GP and NPC1 is an important factor in the tropism of LLOV to a particular bat species.
Insights into the Molecular Mechanisms of the Anti-Atherogenic Actions of Flavonoids in Normal and Obese Mice (2011)

Obesity is a major and independent risk factor for cardiovascular disease and it is strongly associated with the development of dyslipidemia, insulin resistance and type 2 diabetes. Flavonoids, a diverse group of polyphenol compounds of plant origin widely distributed in human diet, have been reported to have numerous health benefits, although the mechanisms underlying these effects have remained obscure. We analyzed the effects of chronic dietary supplementation with flavonoids extracted from cranberry (FLS) in normal and obese C57/BL6 mice compared to mice maintained on the same diets lacking FLS. Obese mice supplemented with flavonoids showed an amelioration of insulin resistance and plasma lipid profile, and a reduction of visceral fat mass. We provide evidence that the adiponectin-AMPK pathway is the main mediator of the improvement of these metabolic disorders. In contrast, the reduced plasma atherogenic cholesterol observed in normal mice under FLS seems to be due to a downregulation of the hepatic cholesterol synthesis pathway. Overall, we demonstrate for the first time that the molecular mechanisms underlying the beneficial effects of flavonoids are determined by the metabolic state.
Childhood Soy Intake and Breast Cancer Risk in Asian American Women (2009)

Soy intake during childhood, adolescence, and adult life was associated with decreased breast cancer risk, with the strongest, most consistent effect for childhood intake. Soy may be a hormonally related, early-life exposure that influences breast cancer incidence.
Metamaterials with discrete nonlinear responses for high-power microwave applications (2013)

Periodic structures have a wide range of applications at RF and microwave frequencies. In recent years, with the emergence of the field of metamateirals, they are receiving even more attention, since most metamateirals are implemented using periodic structures with sub-wavelength periods. Metamaterials capable of operating at high-power microwave levels have also been investigated for applications ranging from new HPM sources to anti-HPM devices and frequency selective surfaces. At high-power levels, however, these devices are susceptible to breakdown. Breakdown events in these devices are accompanied by the creation of plasmas. The nature of this plasma determines how the response of the device changes in the event of a breakdown.
Inferring the user interests using the search history (2011)

Personalization involves the process of gathering user-specific information during interaction with the user, which is then used to deliver appropriate results to the user’s needs. This paper presents a statistical method that learns the user interests by collecting evidence from his search history. The method focuses on the use of both user relevance point of view on familiar words in order to infer and express his interests and the use of a correlation metric measure in order to update them.
Preclinical and clinical research on bone and cartilage regenerative medicine in oral and maxillofacial region (2014)

Abstract Recently, there have been remarkable advances in regenerative medicine, and almost all disorders of the oral and maxillofacial region could be research targets of regenerative medicine. Meanwhile, treatment in this region has been well established using biomaterials, prostheses, and microsurgery. Therefore, to surpass such a conventional approach as an alternative, regenerative medicine should take an approach of being less invasive and/or more effective. In this report, we present our preclinical and clinical research on bone and cartilage regenerative medicine in the oral and maxillofacial region. Regarding bone regenerative medicine, we have tried to develop artificial bone that would maximize bone formation at the transplanted site, but would subsequently be replaced by autologous bone. We have made custom‐made artificial bone (CT‐Bone) using alpha‐tricalcium phosphate (α‐TCP) particles and an ink‐jet printer, and have conducted clinical research and trials on 30 patients. To develop tissue‐engineered cartilage with proper three‐dimensional (3D) morphological form and mechanical strength, we have optimized the culture medium of chondrocytes and the scaffold. Following a preclinical study confirming efficacy and safety, we have conducted clinical research in three patients with nasal deformity associated with cleft lip and palate, and are now starting multicenter clinical research.