gebhart/patrepeval huggingface dataset:
Human monoclonal antibodies to domain C of tenascin-C selectively target solid tumors in vivo (2006)

We had previously reported that splice isoforms of tenascin-C containing the extra-domain C are virtually absent in normal adult tissues but are highly abundant in high-grade astrocytomas, with a prominent peri-vascular pattern of expression. We now report that the extra-domain C of tenascin-C is strongly expressed in the majority of lung cancers, with a vascular and stromal pattern of expression. Using antibody phage technology, we have generated a human monoclonal antibody (G11), with a dissociation constant K(D) = 4.2 nM for the human domain C. The G11 antibody, expressed in scFv and in mini-antibody (SIP) format, as well as a scFv-interleukin-2 fusion protein, was then characterized in quantitative biodistribution studies using mice grafted subcutaneously with U87 gliomas, revealing a selective tumor uptake, with tumor/blood ratios up to 11.8:1 at 24 h. A radioiodinated preparation of SIP(G11) was also investigated in a double tracer study using an orthotopic rat glioma model, confirming the antibody's ability to preferentially localize at the tumor site, with tumor/brain ratios superior to the ones observed with (18)F-fluorodeoxyglucose. These tumor-targeting properties, together with the strong immunohistochemical staining of human tumor sections, indicate that the G11 antibody may be used as a portable targeting moiety for the selective delivery of imaging and therapeutic agents to gliomas and lung tumors.
ChemInform Abstract: Simple and Condensed β‐Lactams. Part 21. Synthesis of Some Compounds Related to the Monobactams, Carrying Non‐Acylamino Substituents in Position 3 and Heterocyclic Quaternary Ammoniomethyl Substituents in Position 4 of the β‐Lactam Ring. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bisabolol. (2010)

Bisabolol is an active plant extract isolated from German chamomile and thought to have antiinflammatory and skin-soothing properties. It is a common additive in many products, including moisturizing creams and ointments, lotions, cleansers, sunscreens, antiperspirants, and makeup products. Contact dermatitis from bisabolol has been reported in Europe and is purported to occur in the United States. Patch testing with bisabolol-containing products or bisabolol may be useful in the work-up of patients with presumptive allergic contact dermatitis or potentially worsening atopic dermatitis. Patients sensitized to bisabolol should be counseled to avoid any bisabolol-containing products.
A Study on Regression of Hypercholesterolemic Atherosclerosis in Rabbits by Flax Lignan Complex (2007)

Flax lignan complex (FLC) isolated from flaxseed suppresses the development of hypercholesterolemic atherosclerosis. The objectives of this study were to investigate if FLC produces regression of atherosclerosis and if regression is associated with reductions in serum lipids and oxidative stress. The studies were conducted in 4 groups of rabbits: group I, control diet (2 months); group II, 0.25% cholesterol diet (2 months); group III, 0.25% cholesterol diet (2 months) followed by regular diet (4 months); and group IV, 0.25% cholesterol diet (2 months) followed by regular diet and FLC (4 months). Serum lipids and oxidative stress parameters were measured before and at various intervals thereafter on their respective diets. The aortas were removed at the end of the protocol for assessment of atherosclerotic plaques and oxidative parameters. Atherosclerosis in group II was associated with hyperlipidemia and increased oxidative stress. Atherosclerotic changes were accelerated in group III, and this was associated with reductions in serum lipids and oxidative stress. Atherosclerotic lesions in group IV were similar to group II, but significantly smaller than those in group III, and were associated with reductions in serum lipids and oxidative stress similar to that in group III. These results indicate that FLC does not produce regression but prevents the acceleration of atherosclerosis due to the removal of cholesterol in the diet. These effects of FLC are not associated with reductions in serum lipids and oxidative stress.
Computability Theory (2017)

Computability theory originated with the seminal work of Gödel, Church, Turing, Kleene and Post in the 1930s. This theory includes a wide spectrum of topics, such as the theory of reducibilities and their degree structures, computably enumerable sets and their automorphisms, and subrecursive hierarchy classifications. Recent work in computability theory has focused on Turing definability and promises to have far-reaching mathematical, scientific, and philosophical consequences. Written by a leading researcher, Computability Theory provides a concise, comprehensive, and authoritative introduction to contemporary computability theory, techniques, and results. The basic concepts and techniques of computability theory are placed in their historical, philosophical and logical context. This presentation is characterized by an unusual breadth of coverage and the inclusion of advanced topics not to be found elsewhere in the literature at this level.The book includes both the standard material for a first course in computability and more advanced looks at degree structures, forcing, priority methods, and determinacy. The final chapter explores a variety of computability applications to mathematics and science.Computability Theory is an invaluable text, reference, and guide to the direction of current research in the field. Nowhere else will you find the techniques and results of this beautiful and basic subject brought alive in such an approachable and lively way.
Effect of Compressor Unsteady Wakes on a Gas Turbine Combustor Flow (2022)

Abstract In gas turbines, combustor inlets are characterised by significant levels of unsteady circumferential distortion due to compressor wakes and secondary flows, together with additional radial non-uniformity induced by the adverse pressure gradients in the pre-diffuser. This can cause non-uniform velocity distributions across the fuel injector, although the exact interaction mechanism, and the effects it has on the downstream air-fuel mixing, is not fully understood. This paper investigates the flow in an a single sector of a fully featured isothermal rig comprising of compression and combustion systems, exploiting the synchronous coupling of a compressible unsteady RANS simulation with a low-Mach LES. Validation against five-hole probe measurements shows that the coupled approach can correctly predict distortion onset and development, with no solution discontinuity at the coupling interface, and is able to preserve unsteady information. The coupled prediction is then compared against a standalone combustor simulation carried out using a circumferentially uniform inlet profile, showing that the additional turbulence from the wakes interacts with the injector, reducing the coherence of the precessing vortex core and potentially affecting the air-fuel mixing characteristics.
SAR Analysis in Dispersive Tissues for In Vivo UWB Body Area Networks (2009)

In this paper, we present the impact on specific absorption ratio (SAR) distribution by dispersive media in wireless body area networks (BAN). For BAN systems, ultrawideband (UWB) transmissions have received much attention because of its low power spectrum and its small antenna size. When we adopt the UWB technique to BAN systems, the SAR analysis is highly demanded for predicting the exposure level prior to experiments and products. It is well-known that the dielectric properties of human tissues have a great spectrum dependency, that renders a difficulty of an SAR analysis by electromagnetic field simulations through the finite-difference time-domain (FDTD) methods for wideband signals. For frequency-dependent analysis, the piecewise linear recursive convolution (PLRC) method is useful for dealing with the dispersive media. To employ the PLRC method, we re-formulate the dielectric spectrum properties of human organs approximating the so-called 4-Cole-Cole model. We reveal that we need to consider the dispersive effect of human tissues to analyze the SAR according to the UWB bandwidth.
Emerging Vaccine Informatics (2010)

Vaccine informatics is an emerging research area that focuses on development and applications of bioinformatics methods that can be used to facilitate every aspect of the preclinical, clinical, and postlicensure vaccine enterprises. Many immunoinformatics algorithms and resources have been developed to predict T- and B-cell immune epitopes for epitope vaccine development and protective immunity analysis. Vaccine protein candidates are predictable in silico from genome sequences using reverse vaccinology. Systematic transcriptomics and proteomics gene expression analyses facilitate rational vaccine design and identification of gene responses that are correlates of protection in vivo. Mathematical simulations have been used to model host-pathogen interactions and improve vaccine production and vaccination protocols. Computational methods have also been used for development of immunization registries or immunization information systems, assessment of vaccine safety and efficacy, and immunization modeling. Computational literature mining and databases effectively process, mine, and store large amounts of vaccine literature and data. Vaccine Ontology (VO) has been initiated to integrate various vaccine data and support automated reasoning.
Downlink Scheduling of Heterogeneous Traffic (2006)

Next generation wireless cellular networks will support a variety of quality-of-service (QoS) sensitive applications like streaming multimedia and high-speed data for downlink users. Channel and QoS aware downlink packet scheduling policies are going to play a key role in efficiently utilizing system resources and enhancing QoS experienced by end users. Schedulers specifically designed to support non-real-time delay tolerant services perform poorly for real-time delay sensitive services, and vice-versa. Scheduler design for supporting a heterogeneous mixture of real-time and non-real-time traffic is a relatively less studied problem. We propose a "quasi-stationary" approach to scheduling of hetergeneous traffic, which involves solving a stationary infinite horizon stochastic shortest-path problem at each scheduling instant. We thoroughly characterize the structural properties of the optimal control associated with the stationary problem, and leverage the intuition thus gained to construct a low-complexity heuristic scheduling policy. We demonstrate the efficacy of the proposed scheduler over benchmark schedulers like the exponential rule via link-level simulations.
Automated generation of visual simulation databases using remote sensing and GIS (1995)

This paper reports on the development of a strategy to generate databases used for real-time interactive landscape visualization. The database construction from real world data is intended to be as automated as possible. The primary sources of information are remote sensing imagery recorded by Landsat's Thematic Mapper (TM) and digital elevation models (DEM). Additional datasets (traffic networks and buildings) are added to extend the database. In a first step the TM images are geocoded and then segmented into areas of different land coverage. During the visual simulation highly detailed photo textures are applied onto the terrain based on the classification results to increase the apparent amount of detail. The data processing and integration is carried out using custom image processing and geographic information systems (GIS) software. Finally, a sample visual simulation application is implemented. Emphasis is put on practical implementation to test the feasibility of the approach as a whole.
Coulomb blockade regions in sputter-deposited titanium nitride films (2018)

We present topographic and spectroscopic scanning tunneling microscopy measurements taken on a 21 nm thick TiN film at a temperature of 4.2 K -- above the superconducting transition temperature (T_c = 3.8 K) of the sample. The film was polycrystalline with crystallite diameters of d~19 nm, consistent with other films prepared under similar conditions. The spectroscopic maps show on average a shallow V-shape around V_b = 0 V consistent with a sample near the Mott insulation transition. In selected regions on several samples we additionally observed signs of Coulomb blockade. The corresponding peak structures are typically asymmetric with respect to bias voltage indicating coupling to two very different tunneling barriers. Furthermore, the peak structures appear with constant peak-peak spacing which indicates quantum dot states within the Coulomb blockade island. In this paper we discuss one such Coulomb blockade area and its implications in detail.
Dissecting Chromatin Architecture for Novel Cardiovascular Disease Targets (2019)

Unraveling the principles of cardiac chromatin organization for next generation therapies in heart disease
MCPIP-1 Restricts Inflammation via Promoting Apoptosis of Neutrophils (2021)

Monocyte chemoattractant protein-induced protein-1 (MCPIP-1) is a potent inhibitor of inflammatory response to pathogens. Acting as endonuclease against transcripts of inflammatory cytokines or transcription factors MCPIP-1 can significantly reduce the cytokine storm, thus limiting the tissue damage. As the adequate resolution of inflammation depends also on the efficient clearance of accumulated neutrophils, we focused on the role of MCPIP-1 in apoptosis and retention of neutrophils. We used peritoneal neutrophils from cell-specific MCPIP-1 knockout mice and showed prolonged survival of these cells. Moreover, we confirmed that MCPIP-1-dependent degradation of transcripts of antiapoptotic genes, including <i>BCL3, BCL2A1, BCL2L1</i>, and for the first time <i>MCL-1</i>, serves as an early event in spontaneous apoptosis of primary neutrophils. Additionally, we identified previously unknown miRNAs as potential binding partners to the <i>MCPIP-1</i> transcript and their regulation suggest a role in MCPIP-1 half-life and translation. These phenomena may play a role as a molecular switch that balances the MCPIP-1-dependent apoptosis. Besides that, we determined these particular miRNAs as integral components of the GM-CSF-MCPIP-1 axis. Taken together, we identified the novel anti-inflammatory role of MCPIP-1 as a regulator of accumulation and survival of neutrophils that simultaneously promotes an adequate resolution of inflammation.
Acoustic properties associated with rectangular geometry supersonic nozzles (1986)

Acoustic property experiments have been conducted to ascertain the behavior of rectangular geometry supersonic nozzles whose throat aspect ratios vary over a 2.0-7.6 range, and whose three partial sidewall geometries range from full to 75-percent cutback. The tests employed unheated air at static conditions for nozzle Mach numbers of 1.35-1.66. It is found that sonic fatigue failures are possible at certain partial sidewall geometries and high nozzle aspect ratios. Unlike axisymmetric supersonic nozzles, shock noise dominates both the rear and forward arc for throat aspect ratio cases greater than 5.6. Jet screech frequency was adequately predicted with a simple vortex sheel model.
Characterization of two types of intranuclear hepatocellular inclusions in NAFLD (2020)

Nuclear inclusions (NI) are a common finding in hepatocytes from patients with liver disease especially in diabetes mellitus and non-alcoholic fatty liver disease (NAFLD) but studies examining the shape and content of these inclusions in detail are lacking. In this study we define two distinct types of NI in NAFLD: inclusions bounded by the nuclear membrane, containing degenerative cell organelles and heterolysosomes (type1) and inclusions with deposits of glycogen but without any kind of organelles and delimiting membrane (type2). NI in 77 paraffin-embedded patients of NAFLD including NAFL and non-alcoholic steatohepatitis (NASH) were analyzed. In 4-12% of type1 NI immunopositivity for the autophagy-associated proteins LC3B, ubiquitin, p62/sequestosome1, cathepsin D and cathepsin B were detected with co-localizations of ubiquitin and p62; type2 NI showed no immunoreactivity. Three-dimensional reconstructions of isolated nuclei revealed that NI type1 are completely enclosed within the nucleus, suggesting that NI, although probably derived from cytoplasmic invaginations, are not just simple invaginations. Our study demonstrates two morphologically different types of inclusions in NAFLD, whereby both gained significantly in number in advanced stages. We suggest that the presence of autophagy-associated proteins and degenerated organelles within type1 NI plays a role in disease progression.
The Relationship Between Interleukin‐10 Gene Polymorphism at Position –1082 and Susceptibility to Gingivitis in Children (2005)

These data suggest that the -1082*A allele could be a risk factor for gingivitis.
S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride by rat hepatic flavin-containing monooxygenase 1 expressed in yeast (1995)

1. Rat hepatic flavin-containing monooxygenase 1 (FMO1) expressed in yeast catalyzed the S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) in vitro. 2. S-oxidation was inhibited by 1-(1-naphthyl)-2-thiourea and thiobenzamide, known inhibitors of FMO, but was not enhanced by n-octylamine, a known enhancer of FMO. 3. The rate of S-oxide formation from SM-12502 was about four-fold lower than that from (+/-)-trans-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-9979) and enantioselectivity and diastereoselectivity of the S-oxidation reaction were observed. 4. The ability of the recombinant yeast to produce the S-oxide from SM-12502 was maintained for long periods and exemplifies the recombinant yeast as a bioreactor to produce a large amount of the S-oxide.
Towards secure multiresolution network coding (2009)

Emerging practical schemes indicate that algebraic mixing of different packets by means of random linear network coding can increase the throughput and robustness of streaming services over wireless networks. However, concerns with the security of streaming multimedia, in particular when only a subset of the users in the network is entitled to the highest quality, have uncovered the need for a network coding scheme capable of ensuring different levels of confidentiality under stringent complexity requirements. We consider schemes which exploit the algebraic structure of network coding to achieve the dual goal of hierarchical fidelity levels and efficient security. The key idea is to limit the encryption operations to the encoding vector, in combination with multi-resolution multimedia coding.
PCR-based RFLP analysis of DNA sequence diversity in the gastric pathogenHelicobacter pylori (1992)

DNA sequence diversity among 60 independent isolates of the gastric pathogen Helicobacter pylori was assessed by testing for restriction fragment length polymorphisms (RFLPs) in several PCR-amplified gene segments. 18 Mbol and 27 HaeIII RFLPs were found in the 2.4 kb ureA-ureB (urease) segment from the 60 strains; this identified 44 separate groups, with each group containing one to four isolates. With one exception, each isolate not distinguished from the others by RFLPs in ureA-ureB was distinguished by Mbol digestion of the neighboring 1.7 kb ureC-ureD segment. The 1.5 kb flaA (flagellin) gene, which is not close to ure gene cluster, was also highly polymorphic. In contrast, isolates from initial and followup biopsies yielded identical restriction patterns in each of the three cases tested. The potential of this method for detecting population heterogeneity was tested by mixing DNAs from different strains before amplification: the arrays of restriction fragments obtained indicated co-amplification from both genomes in each of the five pairwise combinations tested. These results show that H. pylori is a very diverse species, that indicate PCR-based RFLP tests are almost as sensitive as arbitrary primer PCR (RAPD) tests, and suggest that such RFLP tests will be useful for direct analysis of H. pylori in biopsy and gastric juice specimens.
ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding. (1984)

Adenylate cyclase in NG108-15 (neuroblastoma X glioma hybrid) cells is responsive to both stimulatory and inhibitory ligands. Bordetella pertussis toxin (PT) catalyzes the ADP-ribosylation of a 41,000-Da peptide believed to be a subunit of the putative guanyl nucleotide-binding protein (Gi) involved in cyclase inhibition and abolishes inhibitory effects of opiate agonists. In studying the effects of PT on opiate receptors, we found that [3H]enkephalinamide binding was reduced by approximately 90% in membranes prepared from cells incubated with PT compared to control membranes. Agonist affinity, assessed by enkephalinamide competition for [3H]diprenorphine-binding sites, was markedly reduced in cells incubated with PT. Furthermore, inhibition by guanylylimidodiphosphate of ligand binding to opiate receptors was reduced following treatment with PT. The number of opiate receptors assessed by [3H]diprenorphine binding was unaltered by PT. These data are consistent with the hypothesis that PT-catalyzed ADP-ribosylation impairs the interaction of Gi with the inhibitory receptor-ligand complex, effectively uncoupling the inhibitory receptor from Gi and the cyclase catalytic unit.
Supplementary Video S2 from Deletion of Calcineurin Promotes a Protumorigenic Fibroblast Phenotype (2023)

&lt;p&gt;Live cell imaging of PDACs on FDMs.&lt;/p&gt;
The semisitting position: analysis of the risks and surgical outcomes in a contemporary series of 425 adult patients undergoing cranial surgery (2016)

OBJECTIVE The objective of this study was to analyze the incidence of the primary complications related to positioning or surgery and their impact on neurological outcome in a consecutive series of patients undergoing elective surgery in the semisitting position. METHODS The authors prospectively collected and retrospectively analyzed data from adult patients undergoing elective surgery in the semisitting position for a cranial disease. Patients were managed perioperatively according to a standard institutional protocol, a standardized stepwise positioning, and surgical maneuvers to decrease the risk of venous air embolism (VAE) and other complications. Intraoperative and postoperative complications were recorded. Neurointensive care unit (NICU) length of stay (LOS) and hospital LOS were the intermediate endpoints. Neurological outcome was the primary endpoint as determined by the modified Rankin scale (mRS) score at 6 months after surgery. RESULTS Four hundred twenty-five patients were included in the analysis. VAE occurred in 90 cases (21%) and it made no significant statistical difference in NICU LOS, hospital LOS, and neurological outcome. No complication was directly related to the semisitting position, although 46 patients (11%) experienced at least 1 surgery-related complication and NICU LOS and hospital LOS were significantly prolonged in this group. Neurological outcome was significantly worse for patients with complications (p < 0.0001). CONCLUSIONS Even in the presence of intraoperative VAE, the semisitting position was not related to an increased risk of postoperative deficits and can represent a safe additional option for the benefit of specific surgical and patient needs.