gebhart/patrepeval huggingface dataset:
Wiki-connections: Creating synergies within an academic library’s virtual health hub (2010)

Wikis are still considered new technology in an emerging and evolving trend (Web 2.0). In recent years, wikis have been implemented in multi-branch services and standalone libraries. This paper reports on the support a wiki provides a virtual hub of health branches within a university library service. Six of the university’s fourteen branch libraries regularly populate a wiki space with health content, reinforcing synergistic relationships strengthened through a 2008 changed service model. One year later, targeted feedback and a Keepad (clicker) session indicate that health library staff find the space more integral to their daily work than usage statistics imply.
Serpin‐like properties of α1‐antitrypsin Portland towards furin convertase (1998)

Recent studies have demonstrated that a serpin variant, alpha1-antitrypsin Portland (AT-PDX), can inhibit the mammalian convertase furin. Here, we examine the mechanism by which this inhibition takes place. We find that furin, which does not belong to the trypsin-like serine protease family, the usual targets of serpins, forms an SDS-heat denaturation-resistant complex with AT-PDX both in vitro and in vivo. AT-PDX inhibited furin with an association rate constant (k(ass)) of 1.5 x 10(6) M(-1) s(-1) which is similar to k(ass) values reported for serpins with trypsin-like enzymes. These results illustrate that AT can be modified to act essentially as a suicide inhibitor of furin, an enzyme of the subtilase superfamily of serine proteases.
Cold-cathode counting circuits (1955)

IN RECENT years, considerable emphasis has been placed on high-speed counting devices for use in electronic computers and designed to operate at pulse rates of the order of 100 kc, and higher. These of necessity involved hot-cathode electron tubes.
Alizarin Complexone on Nanocrystalline TiO2: A Heterogeneous Approach to Anion Sensing (2004)

Abstract A novel, heterogeneous approach to “naked‐eye” colorimetric and spectrophotometric anion sensing is demonstrated, employing the molecular receptor alizarin complexone adsorbed onto a nanocrystalline, mesoporous TiO 2 film. pH buffer action intrinsic to the TiO 2 film allows dip sensing in aqueous solutions. This heterogeneous sensing system exhibits a high selectivity to F – and CN – anions, high sensitivity, a rapid response time, and excellent reusability.
Heavily doped Au₂₅–ₓAgₓ(SC₆H₁₁)₁₈⁻ nanoclusters: silver goes from the core to the surface (2016)

We report a method for heavy doping of the Au₂₅(SR)₁₈ nanocluster (where R = C₆H₁₁) with silver through the Ag(i)–thiolate complex induced size/structure transformation of Au₂₃(SR)₁₆⁻ into Au₂₅–ₓAgₓ(SR)₁₈⁻. X-ray crystallographic analysis revealed that Ag dopants are distributed not only in the icosahedral core but also in the surface staple motifs; the latter was not achieved in earlier studies of alloy Au₂₅–ₓAgₓ nanoclusters.
Cobalt Oxide on N-Doped Carbon for 1-Butene Oligomerization to Produce Linear Octenes (2017)

Cobalt oxide supported on N-doped carbon catalysts were investigated for 1-butene oligomerization. The materials were synthesized by treating activated carbon with nitric acid and subsequently with NH3 at 200, 400, 600, and 800 °C, followed by impregnation with cobalt. The 1-butene oligomerization selectivity increased with ammonia treatment temperature of the carbon support. The oligomerization selectivity of cobalt oxide on N-doped carbon synthesized at 800 °C (800A-CoOx/N-C) is 2.6 times higher than previously reported cobalt oxide on N-doped carbon synthesized with NH4OH (2A-CoOx/N-C). Over 70% of the butene dimers were linear C8 olefins for all catalysts. The oligomerization selectivity increased with 1-butene conversion. The catalysts were characterized by elemental analysis, N2 adsorption, X-ray diffraction (XRD), X-ray absorption spectroscopy (XAS), and X-ray photoelectron spectroscopy (XPS). The nitrogen content of the catalysts increases with ammonia treatment temperature as confirmed by elemental analysis. The surface content of pyridinic nitrogen with a binding energy of 398.4 ± 0.1 eV increased with ammonia treatment temperature as evidenced by deconvolution of N 1s XPS spectra.
Supplementary Figures S1-S5 from A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers (2023)

&lt;p&gt;Comparison of MYCN and MYC expression levels between MYCN amplified and non-MYCN amplified (non-MNA) neuroblastomas (S1); Prognostic significance of MYCN and MYC genes in non-MYCN amplified neuroblastoma (S2); Relationship between signature score and MYCN protein expression in neuroblastoma (S3); Comparison of signature score between normal and cancerous tissues (S4); Expression of MYCN and signature score in molecular subtypes of HG-SOC (S5).&lt;/p&gt;
Improved Techniques for Quantizing Deep Networks with Adaptive Bit-Widths (2021)

Quantizing deep networks with adaptive bit-widths is a promising technique for efficient inference across many devices and resource constraints. In contrast to static methods that repeat the quantization process and train different models for different constraints, adaptive quantization enables us to flexibly adjust the bit-widths of a single deep network during inference for instant adaptation in different scenarios. While existing research shows encouraging results on common image classification benchmarks, this paper investigates how to train such adaptive networks more effectively. Specifically, we present two novel techniques for quantizing deep neural networks with adaptive bit-widths of weights and activations. First, we propose a collaborative strategy to choose a high-precision teacher for transferring knowledge to the low-precision student while jointly optimizing the model with all bit-widths. Second, to effectively transfer knowledge, we develop a dynamic block swapping method by randomly replacing the blocks in the lower-precision student network with the corresponding blocks in the higher-precision teacher network. Extensive experiments on multiple image classification datasets including video classification benchmarks for the first time, well demonstrate the efficacy of our approach over state-of-the-art methods.
Is continuous infusion of β-lactam antibiotics worthwhile?—efficacy and pharmacokinetic considerations (1996)

The most important pharmacodynamic parameter for beta-lactam antibiotics has been shown to be the time above the MIC, which is used as an argument to administer beta-lactam antibiotics by continuous infusion. Studies in vitro and in laboratory animals comparing efficacy of continuous and intermittent infusion of beta-lactam antibiotics generally show continuous infusion to be more efficacious. While comparative trials in humans are scarce and a significant difference was only found in subgroup analysis in one study, several case-reports support the use of continuous infusion. Arguments in favour and against continuous infusion are discussed. Although dose-ranging studies have not yet been performed in humans, the results from in-vitro and in-vivo experiments indicate that 4 x MIC for the infecting bacterium would be the target concentration. Pharmacokinetic studies which have been performed in humans during continuous infusion show that serum concentrations can be predicted from total clearance or, using population pharmacokinetic modelling, the elimination rate constant as obtained during intermittent infusion. A nomogram is presented which allows calculation of the daily dose to obtain the target steady state blood concentrations suggested by the susceptibility of the infecting bacterium, usually 4 x MIC. For bacteria with a low MIC, the daily dose may be substantially lower than that used in conventional dosing regimens, while in infections which are difficult to treat as a result of more resistant bacteria, continuous infusion may be more effective than an equivalent bolus dose.
ChemInform Abstract: Synthesis and Antihypertensive Activity of 1‐Alkylidene(Arylidene)benzamidrazone Salts (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Zero-Forcing Approximate Log-Likelihood Receiver for MIMO Bit-Interleaved Coded Modulation (2004)

This letter considers multiple-input multiple-output (MIMO) systems with bit-interleaved coded modulation. An approximate log-likelihood decoding approach is presented based on a zero-forcing receiver. The implementation complexity is low compared to the maximum likelihood (ML) receiver. We show that the performance gap, compared to ML, reduces when either the number of receive antennas or the modulation order is increased. Results are presented for both narrowband fast-fading, and orthogonal frequency division multiplexing (OFDM) channels. In the OFDM case, we demonstrate performance gaps as low as 0.5 dB for MIMO extensions to the IEEE 802.11a wireless local area network physical layer standard.
Highly reliable and highly conductive submicron Cu particle patterns fabricated by low temperature heat-welding and subsequent flash light sinter-reinforcement (2016)

An optimized two-step sintering process is developed to achieve highly reliable submicron Cu particle patterns on low-cost, transparent, and flexible substrates.
Comparative PET studies of the distribution of (−)-3,4-methylenedioxy-N-[11C]methamphetamine and (−)-[11C]methamphetamine in a monkey brain (1995)

Carbon-11 labeled (-)-methamphetamine and (-)-3,4-methylenedioxy-N-methamphetamine were synthesized by methylation of the corresponding desmethyl precursors with [11C]H3I in 40-60% yield in a synthesis time of 30 min from EOB with a specific activity of 0.5-1.2 Ci/microM. PET studies in a Rhesus monkey revealed that the uptakes of both compounds in different brain regions were similar, and the retention of radioactivity in these brain regions remained constant throughout the study for the former while it was washed out slowly for the latter. The half-life of (-)-3,4-methylenedioxy-N-methamphetamine in monkey brain was approximately 70 min. Analyses of arterial plasma by HPLC revealed that 50% of radioactivity in the plasma remained as (-)-methamphetamine while only 3% remained as (-)-3,4-methylenedioxy-N-methamphetamine at 60 min post-injection. These results suggest that the uptakes of both compounds in monkey brain are probably not receptor mediated. Rather, blood flow, lipophilicity of the compounds or other transport mechanisms may play a role in their uptakes.
Detecting Symmetric Patterns in EEG Data: A New Method of Analysis (1999)

Theoretical models of higher cognitive function predict that cortical activity will exhibit families of spatial-temporal patterns of activity whose individual members are related to each other by specific symmetry transformations. In the trion model, it is suggested that these inherent symmetries play a vital role in how we think and reason. We have developed a method of analysis (SYMMETRIC analysis), which detects families of patterns in EEG data, and characterizes the symmetry relationships between members of those pattern families. Using this analysis, significant symmetry families have been found in EEG and single unit spike train data. If symmetry is a crucial aspect of brain function, it is possible that different pathologies are associated with specific types of symmetry relationships in brain activity that could be detected in EEG data by a SYMMETRIC analysis.
Microbiology of the Oil Fly, Helaeomyia petrolei (1999)

Helaeomyia petrolei larvae isolated from the asphalt seeps of Rancho La Brea in Los Angeles, Calif., were examined for microbial gut contents. Standard counts on Luria-Bertani, MacConkey, and blood agar plates indicated ca. 2 x 10(5) heterotrophic bacteria per larva. The culturable bacteria represented 15 to 20% of the total population as determined by acridine orange staining. The gut itself contained large amounts of the oil, had no observable ceca, and maintained a slightly acidic pH of 6.3 to 6.5. Despite the ingestion of large amounts of potentially toxic asphalt by the larvae, their guts sustained the growth of 100 to 1,000 times more bacteria than did free oil. All of the bacteria isolated were nonsporeformers and gram negative. Fourteen isolates were chosen based on representative colony morphologies and were identified by using the Enterotube II and API 20E systems and fatty acid analysis. Of the 14 isolates, 9 were identified as Providencia rettgeri and 3 were likely Acinetobacter isolates. No evidence was found that the isolates grew on or derived nutrients from the asphalt itself or that they played an essential role in insect development. Regardless, any bacteria found in the oil fly larval gut are likely to exhibit pronounced solvent tolerance and may be a future source of industrially useful, solvent-tolerant enzymes.
Pteridine, LXXII. Synthese und Eigenschaften von 6‐ und 7‐Amino‐1,3‐dimethyl‐lumazinen (1982)

Abstract Die Synthese von 6‐ und 7‐Amino‐, ‐Methylamino‐ und ‐Dimethylamino‐1,3‐dimethyllumazinen ( 2 — 4 und 12 — 14 ) wird beschrieben, wobei der nucleophile Austausch bei den 7‐Halogen‐1,3‐dimethyllumazinen 10, 11 recht glatt verläuft. Für die Darstellung der 6‐Amino‐Derivate erwies sich dagegen die Amidierung des 6‐Hydroxy‐1,3‐dimethyllumazins ( 1 ) mit Diamidophosphorsäure‐phenylestern als vorteilhafter. Das 6‐Amino‐1,3‐dimethyllumazin ( 2 ) gewinnt man besser aus 6‐Chlor‐1,3‐dimethyllumazin ( 7 ) über das 6‐Hydrazino‐Derivat 5 und nachfolgende Reduktion. Durch p K a ‐Wert‐Bestimmung und Aufnahme der Spektren der Kationen sowie der neutralen Verbindungen läßt sich zeigen, daß die Protonierung in beiden Reihen an N‐5 erfolgt. Die physikalischen Eigenschaften werden diskutiert.
Generation and evaluation of a chimeric antibody against coxsackievirus and adenovirus receptor for cancer therapy (2019)

Coxsackievirus and adenovirus receptor (CAR) is a single-pass transmembrane protein that is associated with adenoviral infection. CAR is involved in the formation of epithelial tight junctions and promotes tumor growth in some cancers. Previously, we developed mouse monoclonal antibodies against human CAR and found that one, mu6G10A, significantly inhibited tumor growth in xenografts of human cancer cells. Herein, we generated and characterized a mouse-human chimeric anti-CAR antibody (ch6G10A) from mu6G10A. ch6G10A had binding activity, inducing antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity, and in vivo anti-tumor activity against CAR-expressing prostate cancer DU-145 cells. In addition, cancer tissue array analysis confirmed that CAR is highly expressed in neuroendocrine lung cancers including small cell lung cancer, and treatment with ch6G10A effectively inhibited in vivo subcutaneous tumor growth of NCI-H69 small cell lung cancer cells in nude mice. Moreover, treatment with mu6G10A effectively inhibited both in vivo orthotopic tumor growth and distant metastatic formation in mouse xenograft models of a highly metastatic subline of human small cell lung cancer DMS273 cells. These results suggest that targeting therapy to CAR with a therapeutic antibody might be effective against several cancer types including small cell lung cancer.
Altitude lakes: source or sink of PCBs for mountain environment ? (2014)

International audience
Modeling Fresh Air Charge and Residual Gas Fraction on a Dual Independent Variable Valve Timing SI Engine (2008)

&lt;div class="htmlview paragraph"&gt;We propose a model of in-cylinder air mass and residual gas fraction of a turbocharged SI engine with Variable Valve Timing (VVT) actuators. VVT devices are used to produce internal exhaust gas recirculation at part load, providing beneficial effects in terms of fuel consumption and pollutant emissions. At full load, VVT actuators permit to push back knock limit by scavenging fresh air to the exhaust pipes. Modeling in-cylinder composition is an essential task for control purpose. Actually, VVT actuators affect in-cylinder fresh air charge. This has an impact on engine torque output (leading to driveability problems), and on Fuel/Air Ratio (leading to pollution peaks). In this paper, we present a model of in-cylinder air mass and residual gas fraction using only commercial-line sensors (engine speed, intake manifold pressure and VVT actuators positions). It is designed for real-time control purpose. The model does not necessitate a lot of calibration time. The proposed method consists in modeling the quantity of fresh air going through the intake valve. The model is composed of three terms. All these terms have their own physical meaning: first term gives in-cylinder total mass, second term gives the gas mass that goes through both valves during the valve overlap (either backflow of burned gas, or scavenging of fresh air), and last term models the residual gas mass staying in the cylinder from one cycle to the next one.&lt;/div&gt;
Completely open-foldable domes remaining cool in sunshine (2016)

These open-foldable very light-weight domes, based on very strong textile membranes highly tensioned between steel bows, are designed for bad-weather protection and maintenance of instruments for astronomical, meteorological and civil-engineering measurements and have extremely high wind stability. The domes of the GREGOR telescope and the Dutch Open Telescope are the two existing prototypes. Improvements were developed with all parts light-colored to remain cool in solar light. The new specially made connection parts (eyes) between the textile parts are made from white-colored PETP, a very strong and UV-stable synthetic, and have a better geometrical shape giving higher stability. The rubber seal tubes on top of the dome were of black-colored chloride rubber CR (neoprene), strong and UV stable, but very warm in sunlight. New UV-stable EPDM rubber tubes were produced in natural light color. To get this rubber stiff enough to give good sealing, a black-colored stiff EPDM rubber is put inside the light-colored one. Tests were performed and the forces necessary for compression of the rubber tubes were measured. An inside black tube with a circa 1.3 times larger compression force than the original black tubes was applied. The assembling of the black tubes into the light-colored tubes was successfully applied at the DOT and GREGOR domes.
An 8b 600MHz flash A/D converter with multistage duplex gray coding (1991)

This paper describes an 8b, 600MHz, flash A/D converter with a unique coding scheme, "Multistage duplex Gray coding". The A/D converter is successfully realized and fabricated with 1.5 um, ft=16GHz, Si bipolar technology.
Citrus aurantium L. Active Constituents, Biological Effects and Extraction Methods. An Updated Review (2021)

<i>Citrus</i> genus is a prominent staple crop globally. Long-term breeding and much hybridization engendered a myriad of species, each characterized by a specific metabolism generating different secondary metabolites. <i>Citrus aurantium</i> L., commonly recognized as sour or bitter orange, can exceptionally be distinguished from other <i>Citrus</i> species by unique characteristics. It is a fruit with distinctive flavor, rich in nutrients and phytochemicals which possess different health benefits. This paper presents an overview of the most recent studies done on the matter. It intends to provide an in-depth understanding of the biological activities and medicinal uses of active constituents existing in <i>C. aurantium</i>. Every plant part is first discussed separately with regards to its content in active constituents. All extraction methods, their concepts and yields, used to recover these valuable molecules from their original plant matrix are thoroughly reported.
Mission-oriented design: A fully autonomous mobile urban robot (2010)

This paper describes a fully autonomous mobile urban robot-X1, which can perform multiple tasks autonomously in an unknown urban environment without human guidance, including mobile reconnaissance, target searching, and object manipulation. The mission-oriented design, which allows reliability and extensibility of the robotic system, includes a high degree of modularity for both hardware and software architecture, and coordination between tasks. Our strategy specifically addresses fundamental issues such as autonomous navigation in unknown urban environments and vision-based object manipulation. All the functionalities have been proved effective in the real urban environments. The robot platform is being built to provide valuable experiences on autonomous robotics research.
P2B-10 Second-Harmonic Aberration Correction (2007)

A simulation study is performed to present results concerning 3D aberration correction for harmonic imaging. Two different correction schemes (a pure time-delay correction and a time-delay and amplitude correction) are employed along with estimation based on either the received first- or second-harmonic frequency. An aberrating body wall is implemented as a 20 mm delay-screen body wall using eight screens, and is tuned to match human abdominal wall characteristics. The transmit pressure of the first harmonic is set to not succeed a mechanical index of 1.1 for the uncorrected case and a pure time-delay correction. Using a time-delay and amplitude correction, the total acoustic energy transmitted is equal to that of the uncorrected case. The total amount of generated second-harmonic energy increases with approximately 1 dB for a pure time-delay correction and about 2 dB for a time-delay and amplitude correction, both estimated at the received first-harmonic frequency. The general side-lobe level of the first- and second-harmonic focal point beam profile averaged over circles around the transducer axis is lowered with 2-10 dB for both correction schemes relative to the uncorrected case.
A Mouse Model for Studying Intrahepatic Islet Transplantation (2004)

Intrahepatic human islet transplantation has raised hopes for a cure for diabetes mellitus, especially in patients with type 1 diabetes; however, the need for a substantial amount of islets and, in many instances, repeated transplantations demonstrates underlying problems with this procedure, such as failure of angiogenesis and immunologic rejection. Studies using rodent models may be helpful in improving the success of islet transplantation. However, most of the studies using rodents for islet transplantation have been under the kidney capsule rather than the liver. Using islets from transgenic mice expressing green fluorescent protein under the control of mouse insulin I promoter, the authors have developed a method with which to visualize histologic and pathologic changes in intraportally transplanted islets and surrounding hepatic tissue using reflected light confocal imaging. Initial events 24 hr after islet transplantation in the liver include beta-cell loss and hepatic ischemic injuries.
Liquid Chromatographic Enantiomer Separation of Non-steroidal Anti-inflammatory Drugs on Immobilized Polysaccharide Derived Chiral Stationary Phase under Reversed and Normal Phase Mode (2009)

1 60% MeOH/water (V/V) with 20 mM methanesulfonic acid 1.13 7.94 1.81 S 1.24 6.70 3.15 S 2 60% MeOH/water (V/V) with 10 mM methanesulfonic acid 1.13 7.74 1.78 S 1.24 6.64 3.10 S 3 60% MeOH/water (V/V) with 5 mM methanesulfonic acid 1.13 7.67 1.74 S 1.24 6.52 3.01 S 4 60% MeOH/water (V/V) with 10 mM ethanesulfonic acid 1.12 7.26 1.70 S 1.22 6.18 2.89 S 5 60% MeOH/water (V/V) with 10 mM trifluoroacetic acid 1.12 6.63 1.08 S 1.21 5.43 1.89 S 6 60% MeOH/water (V/V) with 5 mM trifluoroacetic acid 1.12 6.36 1.02 S 1.21 5.43 1.77 S 7 60% MeOH/water (V/V) with 10 mM trichloroacetic acid 1.12 6.98 1.03 S 1.20 5.33 1.85 S 8 60% MeOH/water (V/V) with 10 mM acetic acid 1.12 5.98 0.97 S 1.20 5.13 1.64 S 9 40% acetonitrile/water (V/V) with 10 mM methanesulfonic acid 1.06 4.61 1.43 S 1.13 2.96 2.64 S 10 40% tetrahydrofuran/water (V/V) with 10 mM methanesulfonic acid 1.00 4.32 1.00 3.21 -