gebhart/patrepeval huggingface dataset:
V‐band injection‐locked oscillator with 9 GHz locking range (2013)

An injection‐locked oscillator (ILO) with a self‐biased injection circuit is proposed. By using the series‐inductive peaking technique, the efficiency of the signal injection is considerably improved. Implemented in Global Foundries 65 nm bulk CMOS process, the proposed ILO demonstrated a 9 GHz locking range and can operate in 52–71 GHz with the tuning mechanism. Occupying a silicon area of 0.3 mm 2 , the circuit draws 13 mA from a 1.2 V supply including the output buffers.
The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics (2021)

The current data provide strong support for continued investigations that examine the risk factors for and biomarkers of AD among diverse populations.
Small punch tensile testing of curved specimens: Finite element analysis and experiment (2016)

The Small Punch (SP) technique is a miniature test used for characterizing irradiated materials or when a testing material is available only in small quantities. In this work Finite Element (FE) models are developed to support the parametric analysis of SP fuel cladding tube specimens in comparison to standard ones. FE analysis shows that there are practically no differences between circular and rectangular flat specimens. The tube specimen results in only slightly higher maximal force (Fm). However, Fm is attained at significantly lower displacements. This is attributed to the curvature of the specimen. The friction linearly increases the Fm and to a lesser extent displacement at Fm. FE analysis also shows that the yield stress and the hardening practically do not affect the Fm. Significant specimen deformation can be expected at already small (0.1 mm) puncher deflection, which could limit the applicability of the small punch test to ductile materials. Varying degree of clamping in the experimental procedure can cause large scatter in the yield stress estimates. In all cases good agreement between the simulation and experimental results was obtained, best with a friction coefficient of 0.2.
Analysis of Natural Convection in Horizontal Concentric Annuli of Varying Inner Shape (2015)

An investigation is presented of free convection in horizontal concentric annuli of varying with inner shape where the inner and outer surfaces are kept at a constant temperature. The simulation is categorized into four groups based on the shape of the inner entity, which is either cylindrical, elliptical, square, or triangular. Flow and thermal fields are exhibited by means of streamlines and isotherms. Overall heat transfer correlations incorporating thermal radiation are established and presented in terms of the Nusselt number. It is observed that the surface radiation and presence of corners and larger top space enhances the heat transfer rate. As the reference temperature increases, surface radiation plays a more prominent role in the overall heat transfer performance.
Distribution of protein I and regulation of its state of phosphorylation in the rabbit superior cervical ganglion (1982)

The distribution and regulation of the state of phosphorylation of Protein I have been studied in the rabbit superior cervical sympathetic ganglion. The data indicate that the ganglion contains two pools of Protein I: a presynaptic pool that represents 60% of the total ganglion Protein I and a postsynaptic pool that represents 40% of the total ganglion Protein I. The state of phosphorylation of presynaptic Protein I, but not that of postsynaptic Protein I, is regulated by nerve impulse conduction, by dopamine, and by a high K+ concentration. Studies of the extracellular calcium requirements for Protein I phosphorylation, as well as peptide-mapping analyses of Protein I, suggest that the effects of nerve impulse conduction and of a high K+ concentration are mediated through the activation of calcium-dependent protein kinases and that the effect of dopamine is mediated through the activation of cyclic AMP-dependent protein kinase. The total amount of postsynaptic Protein I, but not that of presynaptic Protein I, is decreased by short periods of exposure to cycloheximide, a protein synthesis inhibitor. It is proposed that Protein I located in presynaptic nerve terminals plays a functional role in those terminals and that the Protein I located in cell bodies is newly synthesized and en route to nerve terminals.
High-molecular-weight polyethylene glycol protects cardiac myocytes from hypoxia- and reoxygenation-induced cell death and preserves ventricular function (2011)

Apoptosis plays a significant role in maladaptive remodeling and ventricular dysfunction following ischemia-reperfusion injury. There is a critical need for novel approaches to inhibit apoptotic cell death following reperfusion, as this loss of cardiac myocytes can progressively lead to heart failure. We investigated the ability and signaling mechanisms of a high-molecular-weight polyethylene glycol-based copolymer, PEG 15-20, to protect cardiac myocytes from hypoxia-reoxygenation (H-R)-induced cell death and its efficacy in preserving ventricular function following extended hypothermic ischemia and warm reperfusion as relevant to cardiac transplantation. Pretreatment of neonatal rat ventricular myocytes with a 5% PEG solution led to a threefold decline in apoptosis after H-R relative to untreated controls. There was a similar decline in caspase-3 activity in conjunction with inhibition of cytochrome c release from the inner mitochondrial membrane. Treatment with PEG also reduced reactive oxygen species production after H-R, and sarcolemmal lipid-raft architecture was preserved, consistent with membrane stabilization. Cell survival signaling was upregulated after H-R with PEG, as demonstrated by increased phosphorylation of Akt, GSK-3β, and ERK1/2. There was also maintenance of cardiac myocyte β-adrenergic signaling, which is critical for myocardial function. PEG 15-20 was very effective in preserving left ventricular function following prolonged hypothermic ischemia and warm reperfusion. PEG 15-20 has a potent protective antiapoptotic effect in cardiac myocytes exposed to H-R injury and may represent a novel therapeutic strategy to decrease myocardial cell death and ventricular dysfunction at the time of reperfusion during acute coronary syndrome or following prolonged donor heart preservation.
Single-crystal FeFe(CN)6 nanoparticles: a high capacity and high rate cathode for Na-ion batteries (2013)

Prussian blue analogues are actively explored as low cost and high capacity cathodes for Na ion batteries; however, their applications are hindered by low capacity utilization and poor cyclability of these compounds. Here we show that this problem can be solved by controlling the purity and crystallinity of the Prussian blue lattices. As a model compound, single-crystal FeIIIFeIII(CN)6 nanoparticles are synthesized and found to have a sufficiently high capacity of 120 mA h g−1, an exceptional rate capability at 20 C and superior cyclability with 87% capacity retention over 500 cycles, showing great promise for Na ion battery applications. More significantly, these results provide a new insight into the intercalation chemistry of Prussian blue analogues and open new perspectives to develop Na storage cathodes for widespread applications of electric energy storage.
Sustained Release of Human Growth Hormone from Heparin-Based Hydrogel (2008)

ADVERTISEMENT RETURN TO ISSUEPREVNoteSustained Release of Human Growth Hormone from Heparin-Based HydrogelWon Il Choi, Mihye Kim, Giyoong Tae*, and Young Ha KimView Author Information Research Center for Biomolecular Nanotechnology and Department of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Korea, 500-712* To whom correspondence should be addressed. Telephone: 82-62-970-2305 . Fax: 82-62-970-2304. E-mail: [email protected]Cite this: Biomacromolecules 2008, 9, 6, 1698–1704Publication Date (Web):May 6, 2008Publication History Received14 December 2007Revised23 March 2008Published online6 May 2008Published inissue 1 June 2008https://pubs.acs.org/doi/10.1021/bm701391bhttps://doi.org/10.1021/bm701391bbrief-reportACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views1312Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Heparin,Hydrogels,Monomers,Peptides and proteins,Sustained release Get e-Alerts
Versatile Multilayer Thin Film Preparation Using Hydrophobic Interactions, Crystallization, and Chemical Modification of Poly(vinyl alcohol) (2007)

Multilayer thin film coatings were prepared on silicon substrates. Poly(vinyl alcohol) was adsorbed from aqueous solution to propyldimethylsilyl-modified silicon wafers. This thin semicrystalline coating was chemically modified using acid chlorides to form thicker, hydrophobic coatings. The products of the modification reactions allowed adsorption of a subsequent layer of poly(vinyl alcohol) that could subsequently be hydrophobized. This two-step process (adsorption/chemical modification) allows layer-by-layer deposition to prepare coatings with thickness, chemical structure, and wettability control.
Dysregulated skin barrier function in Tmem79 mutant mice promotes IL‐17A‐dependent spontaneous skin and lung inflammation (2020)

Mice lacking Tmem79/Mattrin expression have a defective skin barrier. In adulthood, these mice develop dermatitis with secondary progression to lung inflammation. The development of skin and lung inflammation is IL-17A-dependent and mediated by TCRγδ T cells.
In Human Leukemia Cells Ephrin-B–Induced Invasive Activity Is Supported by Lck and Is Associated with Reassembling of Lipid Raft Signaling Complexes (2008)

Proteins of the ephrin-B group operate in nonlymphoid cells through the control of their migration and attachment, and are crucial for the development of the vascular, lymphatic, and nervous systems. Ephrin-B activity is deregulated in various nonlymphoid malignancies; however, their precise role in cancer has only started to be addressed. We show here that ephrin-B1, a member of the ephrin-B group, is expressed in pediatric T-cell leukemias, including leukemia cell line Jurkat. Treatment of Jurkat cells with ephrin-B-stimulating EphB3 enhances ephrin-B1 phosphorylation and induces its relocalization into lipid rafts. These events are mediated by the T lineage-specific kinase, Lck, as ephrin-B1 phosphorylation and lipid raft association are blocked in the Lck-deficient clone of Jurkat, JCAM1.6. Ephrin-B1 also induces colocalization of the CrkL and Rac1 cytoskeleton regulators and initiates in leukemic cells a strong repulsive response. The absence of Lck blocks ephrin-B1-induced signaling and repulsion, confirming the essential role for Lck in ephrin-B1-mediated responses. This shows a new role for ephrin-B1 in the regulation of leukemic cells through the Lck-dependent Rac1 colocalization with its signaling partner, CrkL, in lipid rafts. In agreement with its repulsive action, ephrin-B1 seems to support metastatic properties of leukemic cells, as suppression of ephrin-B1 signaling inhibits their invasiveness. Because ephrin-B1-activating EphB proteins are ubiquitously expressed, our findings suggest that ephrin-B1 is likely to play an important role in the regulation of malignant T lymphocytes through the control of lipid-raft-associated signaling, adhesion, and invasive activity, and therefore may represent a novel target for cancer treatment.
Quantitative neutron capture radiography for boron in biological specimens (1993)

Track-etch detectors made of cellulose nitrate (LR 115, Kodak Pathé) and polycarbonate (CR 39, Pershore Mouldings Ltd) were compared regarding sensitivity and background when used as detectors for boron determination in biological samples. Measurements were made on two kinds of sample, cryosectioned biological tissue, and liquid samples deposited directly on the detector surface as microdroplets. The CR 39 films were pretreated or washed before irradiation. When cryosectioned tissue was used, measurements were made with and without the inclusion of Mylar foils between the samples and the detectors. Foil thicknesses used were 2 microns in the case of LR 115 and 2, 4, and 6 microns in the case of CR 39. All samples were irradiated with a thermal-neutron fluence of 5 x 10(12) neutrons cm-2 at the thermal-neutron facility in Studsvik, Sweden. The use of a Mylar foil generally suppressed the background tracks relative to the tracks from the 10B disintegration. No difference in resolution between CR 39 and LR 115 was observed. Pretreatment of the CR 39 resulted in an improved sensitivity of detection but the detector became saturated at 0.25 parts per million of 10B. The background was found to be lower in the pretreated detector.
Hypoxia and hypoxia-inducible factor-1α promote growth factor-induced proliferation of human vascular smooth muscle cells (2006)

Hypoxia is thought to be a stimulus for the excessive proliferation of vascular smooth muscle cells (VSMC) that contributes to pulmonary hypertension, but the mechanisms involved are unknown. Here we tested whether hypoxia-inducible factor 1-alpha (HIF-1alpha), a master regulator of the transcriptional response to hypoxia, is involved in the enhanced mitogen-induced proliferative responses of hypoxic VSMC. Exposure to moderate hypoxia (5% O(2)) enhanced the proliferative responses of human pulmonary artery SMC (HPASMC) to mitogens including platelet-derived growth factor (PDGF), fibroblast growth factor 2 (FGF-2), and epidermal growth factor (EGF), compared with those in normoxia (20% O(2)). Moderate hypoxia elicited increased cellular HIF-1alpha levels, shown by Western blot analysis, and also enhanced PDGF-, FGF-2-, and EGF-induced expression of HIF-1alpha. Knockdown of HIF-1alpha or HIF-1beta levels in HPASMC with specific small interfering RNAs inhibited FGF-2-stimulated proliferation of HPASMC incubated in either 5% or 20% O(2) but failed to inhibit the comitogenic effect of hypoxia. Knockdown of HIF-1alpha similarly inhibited PDGF-stimulated proliferation, whereas HIF-2alpha knockdown had no effect on HPASMC proliferation. Knockdown of HIF-1alpha expression also inhibited growth factor-induced expression of cyclin A. We conclude that HIF-1alpha promotes proliferative responses of human VSMC to FGF-2, PDGF, and EGF by mechanisms that may involve HIF-1-dependent expression of cyclin A, but HIF is apparently not crucial to the enhancement of FGF-2-, PDGF-, and EGF-induced proliferation of VSMC that occurs during hypoxia.
ChemInform Abstract: SYNTHESIS OF (Z)‐ AND (E)‐6‐HYDROXYKETAMINE (1985)

Abstract Aus dem Anästheticum Ketamin (Ia) entstehen im Organismus die Metaboliten (IIa) und (IIIa).
Impact of serosal involvement/extramural growth on the risk of synchronous and metachronous peritoneal spread in gastrointestinal stromal tumors: proposal for a macroscopic classification of GIST. (2012)

this study points to extramural growth as a predictor of peritoneal recurrence in GIST, probably as a consequence of tumor rupture or due to microscopic serosal penetration. This study aimed at alerting surgical pathologists to the importance of careful gross and microscopic assessment of resection specimen harboring GIST to allow for reliable prospective evaluation of serosal involvement as an adverse prognostic factor in GIST.
Vapor-Liquid Equilibrium Constants for Carbon Monoxide (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVapor-Liquid Equilibrium Constants for Carbon MonoxideLawrence C. Widdoes and Donald L. KatzCite this: Ind. Eng. Chem. 1948, 40, 9, 1742–1746Publication Date (Print):September 1, 1948Publication History Published online1 May 2002Published inissue 1 September 1948https://pubs.acs.org/doi/10.1021/ie50465a030https://doi.org/10.1021/ie50465a030research-articleACS PublicationsRequest reuse permissionsArticle Views172Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Passive versus electrotransport-facilitated transdermal absorption of ketorolac* (1998)

On average, the F value for the active electrotransport treatment, which exhibited the faster absorption rate, was four times greater than the F for the passive transdermal treatment. Further, during the passive treatment, R-ketorolac yielded an average F that is 42% greater than that for S-ketorolac and also exhibited a smaller absorption lag-time. During the active treatment, there was no important enantiomeric difference in either extent or rate of absorption.
Genes That Are Uniquely Stress Regulated in Salt Overly Sensitive (sos) Mutants (2001)

Repetitive rounds of differential subtraction screening, followed by nucleotide sequence determination and northern-blot analysis, identified 84 salt-regulated (160 mM NaCl for 4 h) genes in Arabidopsis wild-type (Col-0 gl1) seedlings. Probes corresponding to these 84 genes and ACP1, RD22BP1, MYB2, STZ, and PAL were included in an analysis of salt responsive gene expression profiles in gl1 and the salt-hypersensitive mutant sos3. Six of 89 genes were expressed differentially in wild-type and sos3 seedlings; steady-state mRNA abundance of five genes (AD06C08/unknown, AD05E05/vegetative storage protein 2 [VSP2], AD05B11/S-adenosyl-L-Met:salicylic acid carboxyl methyltransferase [SAMT], AD03D05/cold regulated 6.6/inducible2 [COR6.6/KIN2], and salt tolerance zinc finger [STZ]) was induced and the abundance of one gene (AD05C10/circadian rhythm-RNA binding1 [CCR1]) was reduced in wild-type plants after salt treatment. The expression of CCR1, SAMT, COR6.6/KIN2, and STZ was higher in sos3 than in wild type, and VSP2 and AD06C08/unknown was lower in the mutant. Salt-induced expression of VSP2 in sos1 was similar to wild type, and AD06C08/unknown, CCR1, SAMT, COR6.6/KIN2, and STZ were similar to sos3. VSP2 is regulated presumably by SOS2/3 independent of SOS1, whereas the expression of the others is SOS1 dependent. AD06C08/unknown and VSP2 are postulated to be effectors of salt tolerance whereas CCR1, SAMT, COR6.6/KIN2, and STZ are determinants that must be negatively regulated during salt adaptation. The pivotal function of the SOS signal pathway to mediate ion homeostasis and salt tolerance implicates AD06C08/unknown, VSP2, SAMT, 6.6/KIN2, STZ, and CCR1 as determinates that are involved in salt adaptation.
Atomic Layer Deposition on 2D Materials (2017)

2D materials are layered crystalline materials and are the most attractive nanomaterials due to their potentials in next-generation electronics. Because most 2D materials are atomically thin, a suitable fabrication process without degradation of the original properties of the material is required to realize 2D-material-based devices. Atomic layer deposition (ALD) is an ideal technique for adding materials with atomic scaling precision to nanomaterials. Due to the surface-sensitive reactions of ALD, growth on 2D materials is strongly affected by the surface properties of the 2D materials. In this Perspective, ALD growth on 2D materials is reviewed and discussed with previously reported results to provide insights to readers who are investigating 2D materials and relevant topics.
Stereospecific reduction of crotonyl coenzyme A (1962)

An enzyme preparation obtained from brain tissue catalyzes the stereospecific reduction of crotonyl CoA to butyrate. Tritium from TPNH3 was localized predominantly on the β-carbon of recovered butyric acid. Both this enzyme and a preparation from adipose tissue, which also catalyzes the reduction of crotonyl CoA, catalyze the synthesis of long-chain fatty acids from malonyl CoA and acetyl CoA. The significance of these findings is considered in view of the demonstration that, in long-chain fatty acids synthesized in the presence of TPNH3, labeled hydrogen is localized on alternate carbon atoms beginning with the β-carbon.
Age-Related Changes in Vasomotor Reflex Control of Calf Venous Capacitance Response to Lower Body Negative Pressure in Humans. (2002)

The present study was performed to test the hypothesis that calf venous capacitance would be reduced by mild gravitational stress through a vasomotor reflex in humans, and this response could be diminished with advancing age. Nine young (31 +/- 1 years, mean +/- SE) and 9 elderly (69 +/- 1 years) healthy males were exposed to a lower body negative pressure (LBNP) of 15 mmHg. Venous occlusion plethysmography was used to measure calf venous capacitance and calf blood flow. Muscle sympathetic nerve activity (MSNA) was recorded microneurographically from the tibial nerve along with cardiovascular variables. It was found that baseline MSNA was higher [21 +/- 4 (mean +/- SE) vs. 37 +/- 5 bursts x min(-1), young vs. elderly; p < 0.05] and calf venous capacitance was lower (1.71 +/- 0.12 vs. 1.44 +/- 0.10, ml x 100 ml(-1), young vs. elderly; p < 0.05) in the elderly group. At 15 mmHg-LBNP, heart rate and mean arterial pressure both remained unchanged, MSNA was enhanced, and calf blood flow was reduced in all subjects. Calf venous capacitance during LBNP decreased in the young, but did not change in the elderly. A significant negative correlation between percent changes in MSNA and percent changes in calf venous capacitance existed in the young group (y = 20.171x-11.863, r = 20.682; p = 0.0432), but disappeared in the elderly group. The ratio of percent changes in calf venous capacitance to percent changes in MSNA was markedly lower in the elderly (p < 0.01). In conclusion, these results substantiate our hypothesis that calf venous capacitance is reduced by mild LBNP through the vasomotor reflex, and this response is diminished in the elderly.
Liposome Encapsulation of Conjugated Polyelectrolytes:  Toward a Liposome Beacon (2007)

Herein we report the encapsulation of fluorescent conjugated polyelectrolytes (CPEs) within 100 nm diameter liposomes, their subsequent specific immobilization onto polyethylene-glycol-coated glass coverslips and their observation via single molecule spectroscopy. We believe that this novel architecture, a surface tethered liposome beacon, will prove instrumental in developing membrane sensing schemes. It will further facilitate single molecule spectroscopy studies on the spectroscopic properties of CPEs.