gebhart/patrepeval huggingface dataset:
Low temperature thin film solid oxide fuel cells with nanoporous ruthenium anodes for direct methane operation (2011)

Thin film micro-solid oxide fuel cells (µSOFCs) utilizing nanoporous ruthenium (Ru) anodes were fabricated and investigated for direct methane operation for the first time. The µSOFCs consist of 8 mol% yttria-stabilized zirconia (YSZ) thin film electrolytes, porous platinum (Pt) cathodes and porous Ru anodes, fabricated on silicon platforms by physical vapor deposition. The fuel cells, tested with methane as the fuel and air as the oxidant, exhibited an open circuit voltage (OCV) of 0.71 V and a peak power density of 450 mW cm−2 at 500 °C without visually detectable carbon deposition. Structural investigations revealed that the morphology evolution in nanoporous Ru anodes was strongly dependent on the fuels (namely, methane or hydrogen) used, and possible mechanisms leading to the observations are discussed. Results presented here project insights to enable direct use of hydrocarbons with high performance, and are of potential relevance to advancing low temperature micro-fuel cell technology for portable power.
Integrating gene expression and GO classification for PCA by preclustering (2010)

We show that this method leads to an improved interpretability of results in Principal Component Analysis.
Cordycepin- melittin nanoconjugate intensifies wound healing efficacy in diabetic rats (2023)

The current study was designed to develop a nanoconjugate of cordycepin-melittin (COR-MEL) and assess its healing property in wounded diabetic rats. The prepared nanoconjugate has a particle size of 253.5 ± 17.4 nm with a polydispersity index (PDI) of 0.35 ± 0.04 and zeta potential of 17.2 ± 0.3 mV. To establish the wound healing property of the COR-MEL nanoconjugate, animal studies were pursued, where the animals with diabetes were exposed to excision and treated with COR hydrogel, MEL hydrogel, or COR-MEL nanoconjugate topically. The study demonstrated an accelerated wound contraction in COR-MEL nanoconjugate -treated diabetic rats, which was further validated by histological analysis. The nanoconjugate further exhibited antioxidant activities by inhibiting the accumulation of malondialdehyde (MDA) and exhaustion of superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymatic activities. The nanoconjugate further demonstrated an enhanced anti-inflammatory activity by retarding the expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-α. Additionally, the nanoconjugate exhibits a strong expression of transforming growth factor (TGF)-β1, vascular endothelial growth factor (VEGF)-A, and platelet-derived growth factor (PDGFR)-β, indicating enrichment of proliferation. Likewise, nanoconjugate increased the concentration of hydroxyproline as well as the mRNA expression of collagen, type I, alpha 1 (Col 1A1). Thus, it is concluded that the nanoconjugate possesses a potent wound-healing activity in diabetic rats via antioxidant, anti-inflammatory, and pro-angiogenetic mechanisms.
Peri-Implant Diseases: Characteristics of the Microbiota and of the Host Response in Humans – A Narrative Review (2020)

The present narrative review provides a summary of the temporal and spatial reactions of the oral microbiome to the placement of a dental implant into the oral cavity, depicting the most important interactions between the oral microbiota and the host response involved in the development of peri-implant infections in humans (i.e., peri-implant mucositis and peri-implantitis). Starting with the formation of a pellicle to acute and rampant peri-implant inflammation, a number of steps, including biofilm formation, aggressive bacterial invasion, and host defense mechanisms, are involved. Better understanding of the factors related to the host response and changes in the composition of microbiota has led to the development of novel treatment modalities. Finally, a short outlook into the future is provided.
Thermal resistivity of quaternary solid solutions InGaSbAs and GaAlSbAs lattice-matched to GaSb (1990)

Measurement of the thermal resistivity of the materials InGaSbAs and GaAlSbAs is reported. These materials have thermal resistivities of three to four times that of the GaSb substrate to which they were lattice matched. This makes them particularly suitable for use as the active medium in semiconductor light sources.
Sodium metabisulfite as a contact allergen – an example of a rare chemical mechanism for protein modification (2012)

Sodium metabisulfite is an unusual but not infrequent contact allergen whose chemistry suggests a previously unrecognized protein modification mechanism involving nucleophilic attack by sulfite di-anions on target electrophilic centres in skin proteins. The chemical properties required for sensitization by nucleophilic attack on skin proteins are quite restrictive, so the domain of nucleophilic sensitizers is expected to be small. Thiourea derivatives are among the sensitizers likely to act by this mechanism.
Model reference adaptive control for the azimuth‐pointing system of a balloon‐borne stabilized platform (1991)

Abstract A balloon‐born stabilized platform has been developed for the remotely operated altitude‐azimuth pointing of a millimetre wave telescope system. This paper presents a development and implementation of model reference adaptive control (MRAC) for the azimuth‐pointing system of the stabilized platform. The primary goal of the controller is to achieve pointing RMS better than 0.1°. Simulation results indicate that MRAC can achieve pointing RMS better than 0.01°. Ground test results show pointing RMS better than 0.03°. Data from the first flight at the National Scientific Balloon Facility (NSBF), Palestine, TX show pointing RMS better than 0.02°.
In vitro resistance to dexamethasone of basophils from patients receiving long-term steroid therapy. (1985)

Previous studies have shown that in vitro culture of human basophils for 24 h with physiologic concentrations of glucocorticoids leads to a pronounced inhibition of the subsequent release of histamine or leukotrienes when the cells are challenged with anti-IgE. However, both acute and chronic therapy in vivo with steroids fails to lead to an impairment of subsequent histamine release in vitro. To test whether the failure of in vivo steroid therapy to inhibit subsequent in vitro histamine release was due to the selection of a subpopulation of basophils that responded normally to anti-IgE but were resistant to steroids, the in vitro sensitivity to inhibition of mediator release by steroids in basophils obtained from normal patients as well as patients receiving chronic steroid therapy was studied. Basophils from steroid-dependent asthmatics (SDA) who had been receiving steroid doses orally of 7.5 to 50 mg equivalents of prednisone per day (mean, 19 mg), patients with collagen vascular disease (CVD) who had been receiving steroids orally of 4 to 80 mg equivalents (mean, 25 mg), non-steroid-dependent asthmatics (NSDA), and normal subjects were prepared, and their in vitro response to the potent glucocorticoid, dexamethasone, was determined. Dexamethasone was considerably more effective as an inhibitor of histamine release from basophils of normal subjects and NSDA than from basophils of SDA and patients with CVD. Because this was true in both SDA and patients with CVD, it seems most likely to be the result of the treatment with steroids rather than the underlying disease processes. Such a finding may be the result of a steroid-induced selection process by which sensitive cells are removed from the bloodstream in steroid-treated persons.
In Situ Analysis of Epstein-Barr Viral Expression in Nasopharyngeal Carcinoma (1991)

Epstein-Barr virus (EBV) has a known association with several malignancies including African Burkitt’s lymphoma (BL) 1, nasopharyngeal carcinoma (NPC)2 and diffuse polyclonal non-Burkitt lymphomas in transplant patients3.
Performance Improvement of Word Clustering Using Ontology (2006)

이 논문은 사전의 뜻 풀이말을 이용하여 단어 군집화 시스템을 설계하고 구현한다. 군집화를 위해서는 다양한 형태의 자질이 요구되며 어떤 자질을 사용하느냐에 따라 군집화의 성능이 좌우된다. 뜻 풀이말은 표제어를 자세히 설명하고 있기는 하지만, 뜻 풀이말에 사용된 단어가 너무 함축적이거나 추상적이어서 뜻 풀이말이 그다지 길지 않다. 뜻 풀이말로부터 추출된 자질을 그대로 군집화에 이용할 경우에는 다수의 작은 군집이 형성된다. 뜻 풀이말을 이용하여 보다 더 좋은 군집화 결과를 얻기 위해서는 뜻 풀이말의 의미를 크게 손상하지 않는 범위에서 보다 더 일반적인 단어로 바꾸어 군집화에 필요한 자질을 확장할 필요가 있다. 이 논문에서 추상적인 말을 온톨로지 상에서 한 단계 위의 단어로 확장하거나 온톨로지 상에서 고정 높이에 해당하는 단어로 확장함으로써 단어 군집화 성능을 향상시키는 방법을 제안한다. 실험을 통해서 온톨로지를 이용해서 자질을 확장할 경우 단어 군집화 성능이 크게 개선되었으며, 전체적으로 보면 온톨로지 상에서 고정 높이에 해당하는 단어로 확장할 경우가 더 좋은 성능을 보였다. 또한 단어 군집화를 위한 자질로 동사가 매우 유용함을 관찰할 수 있었다. In this paper, we describe the design and the implementation of word clustering system using a definition of an entry word in the dictionary, called a dictionary definition. Generally word clustering needs various features like words and the performance of a system for the word clustering depends on using some kinds of features. Dictionary definition describes the meaning of an entry in detail, but words in the dictionary definition are implicative or abstractive, and then its length is not long. The word clustering using only features extracted from the dictionary definition results in a lots of small-size clusters. In order to make large-size clusters and improve the performance, we need to transform the features into more general words with keeping the original meaning of the dictionary definition as intact as possible. In this paper, we propose two methods for extending the dictionary definition using ontology. One is to extend the dictionary definition to parent words on the ontology and the other is to extend the dictionary definition to some words in fixed depth from the root of the ontology. Through our experiments, we have observed that the proposed systems outperform that without extending features, and the latter's extending method overtakes the former's extending method in performance. We have also observed that verbs are very useful in extending features in the case of word clustering.
Superconducting Transition of GdBa2Cu3O7-x (1987)

The superconducting transition of GdBa 2 Cu 3 O 7- x has been studied in terms of complex susceptibility and ac resistance. The results suggest the superconducting transition of a disk sample takes place through the concurrence of the bulk and coupled phases. The ac-resistive measurement of a disk sample as well as the complex-susceptibility measurement of a powdered sample support the above results. Discussion was made with the aid of the weak-link loop model.
Supplementary Materials and Methods, Figure Legends 1-5 from The Hedgehog Receptor Patched Functions in Multidrug Transport and Chemotherapy Resistance (2023)

&lt;p&gt;PDF file - 97K&lt;/p&gt;
Supplementary Figure 3 from DNA Methylation Does Not Stably Lock Gene Expression but Instead Serves as a Molecular Mark for Gene Silencing Memory (2023)

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A Study of the Hydration of the Alkali Metal Ions in Aqueous Solution (2011)

The hydration of the alkali metal ions in aqueous solution has been studied by large angle X-ray scattering (LAXS) and double difference infrared spectroscopy (DDIR). The structures of the dimethyl sulfoxide solvated alkali metal ions in solution have been determined to support the studies in aqueous solution. The results of the LAXS and DDIR measurements show that the sodium, potassium, rubidium and cesium ions all are weakly hydrated with only a single shell of water molecules. The smaller lithium ion is more strongly hydrated, most probably with a second hydration shell present. The influence of the rubidium and cesium ions on the water structure was found to be very weak, and it was not possible to quantify this effect in a reliable way due to insufficient separation of the O-D stretching bands of partially deuterated water bound to these metal ions and the O-D stretching bands of the bulk water. Aqueous solutions of sodium, potassium and cesium iodide and cesium and lithium hydroxide have been studied by LAXS and M-O bond distances have been determined fairly accurately except for lithium. However, the number of water molecules binding to the alkali metal ions is very difficult to determine from the LAXS measurements as the number of distances and the temperature factor are strongly correlated. A thorough analysis of M-O bond distances in solid alkali metal compounds with ligands binding through oxygen has been made from available structure databases. There is relatively strong correlation between M-O bond distances and coordination numbers also for the alkali metal ions even though the M-O interactions are weak and the number of complexes of potassium, rubidium and cesium with well-defined coordination geometry is very small. The mean M-O bond distance in the hydrated sodium, potassium, rubidium and cesium ions in aqueous solution have been determined to be 2.43(2), 2.81(1), 2.98(1) and 3.07(1) Å, which corresponds to six-, seven-, eight- and eight-coordination. These coordination numbers are supported by the linear relationship of the hydration enthalpies and the M-O bond distances. This correlation indicates that the hydrated lithium ion is four-coordinate in aqueous solution. New ionic radii are proposed for four- and six-coordinate lithium(I), 0.60 and 0.79 Å, respectively, as well as for five- and six-coordinate sodium(I), 1.02 and 1.07 Å, respectively. The ionic radii for six- and seven-coordinate K(+), 1.38 and 1.46 Å, respectively, and eight-coordinate Rb(+) and Cs(+), 1.64 and 1.73 Å, respectively, are confirmed from previous studies. The M-O bond distances in dimethyl sulfoxide solvated sodium, potassium, rubidium and cesium ions in solution are very similar to those observed in aqueous solution.
Engineering workstation: Sensor modeling (1993)

The purpose of the engineering workstation is to provide an environment for rapid prototyping and evaluation of fusion and image processing algorithms. Ideally, the algorithms are designed to optimize the extraction of information that is useful to a pilot for all phases of flight operations. Successful design of effective fusion algorithms depends on the ability to characterize both the information available from the sensors and the information useful to a pilot. The workstation is comprised of subsystems for simulation of sensor-generated images, image processing, image enhancement, and fusion algorithms. As such, the workstation can be used to implement and evaluate both short-term solutions and long-term solutions. The short-term solutions are being developed to enhance a pilot's situational awareness by providing information in addition to his direct vision. The long term solutions are aimed at the development of complete synthetic vision systems. One of the important functions of the engineering workstation is to simulate the images that would be generated by the sensors. The simulation system is designed to use the graphics modeling and rendering capabilities of various workstations manufactured by Silicon Graphics Inc. The workstation simulates various aspects of the sensor-generated images arising from phenomenology of the sensors. In addition, the workstation can be used to simulate a variety of impairments due to mechanical limitations of the sensor placement and due to the motion of the airplane. Although the simulation is currently not performed in real-time, sequences of individual frames can be processed, stored, and recorded in a video format. In that way, it is possible to examine the appearance of different dynamic sensor-generated and fused images.
Closed-loop identification and control application for dissolved oxygen concentration in a full-scale coke wastewater treatment plant (2001)

The objective of this paper is to apply a closed-loop identification to actual dissolved oxygen control system in the coke wastewater treatment plant. It approximates the dissolved oxygen dynamics to a high order model using the integral transform method and reduces it to the first-order plus time delay (FOPTD) or second-order plus time delay (SOPTD) for the PID controller tuning. To experiment the process identification on the real plant, a simple set-point change of the speed of surface aerator under the closed-loop control without any mode change was used as an activation signal of the identification. The full-scale experimental results show a good identification performance and a good tracking ability for set-point change. As a result of improved control performance, the fluctuation of dissolved oxygen concentration variation has been decreased and the electric power saving has been accomplished.
Effects of Type 2 Diabetes and Insulin on Whole-Body, Splanchnic, and Leg Protein Metabolism (2012)

T2D results in higher whole-body, splanchnic, and leg protein turnover and blunts the insulin-mediated suppression of splanchnic protein anabolism under hyperglycemic, hyperinsulinemic conditions.
MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy (2006)

Patients with recurrent gliomas (n = 14) were treated with bevacizumab and carboplatin, cpt-11, or etoposide. Follow-up MRI scans were obtained 2 to 6 weeks after initiation of treatment. Contrast-enhancing tumor shrank in 7 patients, with reductions evident in as little as 2 weeks after initiation of therapy. Treatment seemed more effective for heterogeneously enhancing tumor compared with solidly enhancing tumor.
Optimization methods for 2‐D prestack migration velocity estimation (1993)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1993Optimization methods for 2‐D prestack migration velocity estimationAuthors: Michael JervisMrinal SenPaul L. StoffaMichael JervisUniversity of Texas at Austin, Mrinal SenUniversity of Texas at Austin, and Paul L. StoffaUniversity of Texas at Austinhttps://doi.org/10.1190/1.1822669 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1822669FiguresReferencesRelatedDetailsCited ByDeep learning network optimization and hyperparameter tuning for seismic lithofacies classificationMichael Jervis, Mingliang Liu, and Robert Smith1 July 2021 | The Leading Edge, Vol. 40, No. 7 SEG Technical Program Expanded Abstracts 1993ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1993 Pages: 1396 publication data© 1993 Copyright © 1993 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Michael Jervis, Mrinal Sen, and Paul L. Stoffa, (1993), "Optimization methods for 2‐D prestack migration velocity estimation," SEG Technical Program Expanded Abstracts : 965-968. https://doi.org/10.1190/1.1822669 Plain-Language Summary PDF DownloadLoading ...
Honokiol-Chlorambucil Co-Prodrugs Selectively Enhance the Killing Effect through STAT3 Binding on Lymphocytic Leukemia Cells In Vitro and In Vivo (2020)

The broad-spectrum DNA alkylating therapeutic, chlorambucil (CBL), has limited safety and shows lower therapy effect because of a short half-life while used in the clinic. Therefore, it is very necessary to develop a more efficient and safer type of CBL derivate against tumors with selective targeting of cancer cells. In addition, the natural product of honokiol (HN), the novel potent chemo-preventive or therapeutic entity/carrier, can target the mitochondria of cancer cells through STAT3 to prevent cancer from spreading and metastasizing. In this study, we designed and synthesized the honokiol-chlorambucil (HN-CBL) co-prodrugs through carbonate ester linkage conjugating with the targeted delivery help of the HN skeleton in cancer cells. Biological evaluation indicated that HN-CBL can remarkably enhance the antiproliferation of human leukemic cell lines CCRF-CEM, Jurkat, U937, MV4-11, and K562. Furthermore, HN-CBL can also selectively inhibit the lymphocytic leukemia (LL) cell survival compared to those mononuclear cells derived from healthy donors (PBMCs), enhance mitochondrial activity in leukemia cells, and induce LL cell apoptosis. Molecular docking and western blot study showed that HN-CBL can also bind with the STAT3 protein at some hydrophobic residues and downregulate the phosphorylation level of STAT3-like HN. Significantly, HN-CBL could dramatically delay leukemia growth <i>in vivo</i> with no observable physiological toxicity. Thus, HN-CBL may provide a novel and effective targeting therapeutic against LL with fewer side effects.
Additional DNA in methicillin-resistant Staphylococcus aureus and molecular cloning of mec-specific DNA (1986)

Additional DNA was shown to be present in methicillin-resistant Staphylococcus aureus by one- and two-dimensional restriction endonuclease analyses of the chromosomal DNA. A 3.5-kilobase Bg/II fragment, which was present in methicillin-resistant strains but not in the isogenic methicillin-sensitive parental strain, was cloned into newly constructed plasmid pWDB1 in Escherichia coli. Hybridization of this 3.5-kilobase Bg/II fragment with different methicillin-sensitive and methicillin-resistant S. aureus clinical isolates indicated that the fragment represents part of the methicillin resistance determinant (mec). In addition, the fragment carries a sequence that is present in some large staphylococcal plasmids, as well as in penicillinase plasmid pI524.
PO-015 DNA damage response reporters in breast cancer (2018)

Introduction The DNA damage response is a powerful tool of the cell to protect the genome by preventing replication of genetic mutations. A well-known defect in DNA repair is caused by mutations in the BRCA gene, present in several hereditary breast and ovarian cancers. BRCA proteins are essential for DNA repair via Homologous Recombination (HR), making these cancers hypersensitive to PARP1 inhibition. HR can be monitored by assessing RAD51 or RAD54 foci formation. Material and methods To stably transfect cells we used the PiggyBac vector system. We made a Fucci construct with labelled cell cycle markers Cdt1 and geminin. The EGFP-RAD51 and RAD54-EGFP reporters were made under the control of an inducible promoter. We created stable MCF7 breast cancer cell lines with the reporters. As tumour model for breast cancer we made MCF7 spheroids, cultured in hanging drop cultures. Results and discussions We developed MCF7 cell lines, stably expressing EGFP-RAD51 or RAD54-EGFP and a combination of RAD51 or RAD54 with the Fucci construct. We could culture spheroids from MCF7 cells and MCF7 stably transfected cell lines for at least 7 days. We are now working on the validation of the HR reporters for studying focus formation in MCF7 spheroids. With these HR reporters in combination with the Fucci construct we will study the formation kinetics of foci in 3D tumour tissue cultures with the final goal to assess which tumours are HR deficient and therefore may successfully be treated with PARP inhibitors. Conclusion We successfully created MCF7 cell lines stably containing doxycycline-inducible expression of EGFP-RAD51 or RAD54-EGFP or which stably expressed the Fucci cell cycle reporter construct. These MCF7 cells form spheroids expressing reporters, which will help us study HR in 3D cultures.
Eigenvalue-based harmonic stability analysis method in inverter-fed power systems (2015)

This paper presents an eigenvalue-based harmonic stability analysis method for inverter-fed power systems. A full-order small-signal model for a droop-controlled Distributed Generation (DG) inverter is built first, including the time delay of digital control system, inner current and voltage control loops, and outer droop-based power control loop. Based on the inverter model, an overall small-signal model of a two-inverter-fed system is then established, and the eigenvalue-based stability analysis is subsequently performed to assess the influence of controller parameters on the harmonic resonance and instability in the power system. Eigenvalues associated with time delay of inverter and inner controller parameters is obtained, which shows the time delay has an important effect on harmonic instability of inverter-fed power systems. Simulation results are given for validating the proposed harmonic stability analysis method.