gebhart/patrepeval huggingface dataset:
A Mild and Efficient Method for the Stereoselective Formation of C−O Bonds:  Palladium-Catalyzed Allylic Etherification Using Zinc(II) Alkoxides (2002)

[reaction: see text] A highly chemo- and stereoselective palladium-catalyzed allylic etherification reaction is described. The use of zinc(II) alkoxides proved effective in promoting the addition of the oxygen nucleophile derived from aliphatic alcohols to eta(3)-allylpalladium complexes. Using diethylzinc (0.5 equiv), 5 mol % of Pd(OAc)(2), and 7.5 mol % of 2-di(tert-butyl)phosphinobiphenyl in THF, the cross-coupling reaction between various aliphatic alcohols and allylic acetates proceeded at ambient temperature to furnish allylic ethers with high stereoselectivity.
Volume Discovery: Leveraging Liquidity in the Depth of an Order Driven Market (2006)

Electronic order book trading has evolved in being recognized as the best‐practice for trading small and mid‐sized orders. Yet, this mechanism does not properly address the needs of large‐sized orders which tend to execute off order book in over‐the‐counter markets. Order book trading provides for public price discovery but not for quantity discovery. Off book executions generally fragment the order flow which again adversely impacts price discovery. We propose a market model innovation to close this gap: ‘Volume Discovery’ introduces the new order type ‘volume order’ to integrate large sized orders into the book. The volume order builds on the concept of iceberg order but is enhanced by two parameters ‘hidden limit’ and ‘minimum volume’, which continuously search order book depth for matching quantity. For large orders, Volume Discovery leverages already existent liquidity to benefit block trading by increased likelihood of execution and reduced opportunity costs. For all orders, Volume Discovery promotes the integration of OTC markets and order book trading in order to improve liquidity while protecting price/time priority.
Regulation of ABCG1 expression in human keratinocytes and murine epidermis (2010)

ABCG1, a member of the ATP binding cassette superfamily, facilitates the efflux of cholesterol from cells to HDL. In this study, we demonstrate that ABCG1 is expressed in cultured human keratinocytes and murine epidermis, and induced during keratinocyte differentiation, with increased levels in the outer epidermis. ABCG1 is regulated by liver X receptor (LXR) and peroxisome proliferator-activated receptor-δ (PPAR-δ) activators, cellular sterol levels, and acute barrier disruption. Both LXR and PPAR-δ activators markedly stimulate ABCG1 expression in a dose- and time-dependent fashion. PPAR-γ activators also increase ABCG1 expression, but to a lesser degree. In contrast, activators of PPAR-α, retinoic acid receptor, retinoid X receptor, and vitamin D receptor do not alter ABCG1 expression. In response to increased intracellular sterol levels, ABCG1 expression increases, whereas inhibition of cholesterol biosynthesis decreases ABCG1 expression. In vivo, ABCG1 is stimulated 3-6 h after acute barrier disruption by either tape stripping or acetone treatment, an increase that can be inhibited by occlusion, suggesting a potential role of ABCG1 in permeability barrier homeostasis. Although Abcg1-null mice display normal epidermal permeability barrier function and gross morphology, abnormal lamellar body (LB) contents and secretion leading to impaired lamellar bilayer formation could be demonstrated by electron microscopy, indicating a potential role of ABCG1 in normal LB formation and secretion.
Spacetime constraints (1988)

Spacetime constraints are a new method for creating character animation. The animator specifies what the character has to do, for instance, "jump from here to there, clearing a hurdle in between;" how the motion should be performed, for instance "don't waste energy," or "come down hard enough to splatter whatever you land on;" the character's physical structure---the geometry, mass, connectivity, etc. of the parts; and the physical resources' available to the character to accomplish the motion, for instance the character's muscles, a floor to push off from, etc. The requirements contained in this description, together with Newton's laws, comprise a problem of constrained optimization. The solution to this problem is a physically valid motion satisfying the "what" constraints and optimizing the "how" criteria. We present as examples a Luxo lamp performing a variety of coordinated motions. These realistic motions conform to such principles of traditional animation as anticipation, squash-and-stretch, follow-through, and timing.
Simulating Powder Bed Based Additive Manufacturing Processes: From DEM Calibration to Experimental Validation (2021)

Powder flowability is a critical parameter for additive manufacturing techniques involving powders. In order to obtain thin and homogenous powder layers, a compromise between grain size and flowability has to be found. Unfortunately, when the grain size decreases, the cohesiveness increases and the flowability decreases. Too often, both the powder spreadability assessment and the optimization of printing parameters are costly empiric processes. In this paper, we describe an original method associating GranuDrum powder flow characterization instrument and DEM numerical simulations to asses the process-ability of powders and to optimize printing parameters like recoater speed, layer thickness or recoater geometry. The powder characterization allows to calibrate the simulation parameters and in particular to quantify the inter-grain cohesiveness. Then, the recoating process is simulated with the calibrated simulations to predict the behaviour of the powder inside the printer. In parallel, the results are validated by testing the powder in a printer equipped with an in-situ powder layer homogeneity tester based on image analysis.
Grafoil–Scotch tape-derived highly conducting flexible substrate and its application as a supercapacitor electrode (2017)

Development of flexible supercapacitors is limited by the availability of flexible and durable conducting substrates; a conducting and cheap substrate for the active material deposition is essential for breakthrough progress in this direction. In this report, a highly flexible, conducting, and cheap substrate is prepared by simple stick and peel-off method involving Scotch tape and Grafoil. A Grafoil-Scotch tape derived flexible substrate exhibits a sheet resistance of 7 Ω □<sup>-1</sup> along with a high degree of flexibility and durability. Moreover, its properties are further enhanced by the anodization in order to increase the hydrophilicity and surface area. The substrate is highly thin with a thickness of just 74 μm. Its practical utility has been demonstrated by electrodepositing MnO<sub>2</sub> as an active material and, thereafter, fabricating a solid-state flexible supercapacitor. The fabricated device exhibits high capacitance retention under bent (99%) and twisted (98%) conditions along with a low ESR of 7 Ω.
Multi-function control of small-scaled grid-connected PV systems (2021)

The installation capacity of the grid-connected small-scaled PV systems in distribution grids is remarkable. Therefore, the capacity of these systems can play an important role in distribution grids. By applying a proper control, these systems can, in addition to their energy source, be used as a harmonic and voltage compensators at the point of common coupling (PCC). This paper presents a multi-functions control scheme for small-scaled PV systems. In the presented approach, the control system, in addition to delivering the energy of the panels to the grid, will put the solar system in the harmonic and voltage compensation process at the PCC. Both the voltage and harmonic compensation strategies are implemented by on-line analysing the PCC voltage. The structure in the proposed approach is a single-phase transformerless HERIC inverter with the LCL filter at the output. Finally, the results will be evaluated by MATLAB simulator and verified by experimental prototype.
Novel molecular biological tools for the efficient expression of fungal lytic polysaccharide monooxygenases in Pichia pastoris (2021)

The work demonstrates that the industrially most relevant expression host P. pastoris can be used to express fungal LPMOs from different families in high yields and inherent purity. The presented protocols are standardized and require little equipment with an additional advantage with short cultivation periods.
First Molecular Identification of Human Dobrava Virus Infection in Central Europe (2004)

Viral RNA was amplified by reverse transcription-PCR from a patient suffering from hemorrhagic fever with renal syndrome (HFRS) in Germany. The virus strain could be assigned to the Dobrava hantavirus (DOBV). This is the first molecular identification of human infection by DOBV in central Europe and the first proof that a virus strain related to the DOBV-Aa lineage, carried by Apodemus agrarius rodents, is able to cause HFRS.
Excessive erythrocytosis in adult mice overexpressing erythropoietin leads to hepatic, renal, neuronal, and muscular degeneration (2006)

To investigate the consequences of inborn excessive erythrocytosis, we made use of our transgenic mouse line (tg6) that constitutively overexpresses erythropoietin (Epo) in a hypoxia-independent manner, thereby reaching hematocrit levels of up to 0.89. We detected expression of human Epo in the brain and, to a lesser extent, in the lung but not in the heart, kidney, or liver of tg6 mice. Although no acute cardiovascular complications are observed, tg6 animals have a reduced lifespan. Decreased swim performance was observed in 5-mo-old tg6 mice. At about 7 mo, several tg6 animals developed spastic contractions of the hindlimbs followed by paralysis. Morphological analysis by light and electron microscopy showed degenerative processes in liver and kidney characterized by increased vascular permeability, chronic progressive inflammation, hemosiderin deposition, and general vasodilatation. Moreover, most of the animals showed severe nerve fiber degeneration of the sciatic nerve, decreased number of neuromuscular junctions, and degeneration of skeletal muscle fibers. Most probably, the developing demyelinating neuropathy resulted in muscular degeneration demonstrated in the extensor digitorum longus muscle. Taken together, chronically increased Epo levels inducing excessive erythrocytosis leads to multiple organ degeneration and reduced life expectancy. This model allows investigation of the impact of excessive erythrocytosis in individuals suffering from polycythemia vera, chronic mountain sickness, or in subjects tempted to abuse Epo by means of gene doping.
Patch Transformer for Multi-tagging Whole Slide Histopathology Images (2019)

Automated whole slide image (WSI) tagging has become a growing demand due to the increasing volume and diversity of WSIs collected nowadays in histopathology. Various methods have been studied to classify WSIs with single tags but none of them focuses on labeling WSIs with multiple tags. To this end, we propose a novel end-to-end trainable deep neural network named Patch Transformer which can effectively predict multiple slide-level tags from WSI patches based on both the correlations and the uniqueness between the tags. Specifically, the proposed method learns patch characteristics considering 1) patch-wise relations through a patch transformation module and 2) tag-wise uniqueness for each tagging task through a multi-tag attention module. Extensive experiments on a large and diverse dataset consisting of 4,920 WSIs prove the effectiveness of the proposed model.
Role of high-dose hydrochlorothiazide in idiopathic hypercalciuric urolithiasis of childhood. (2011)

Our study showed that a combination of diet modification and hydrochlorothiazide has reasonable hypocalciuric effects; however, it is not very efficient in stopping calculus formation process. In addition, clinical and radiological data were not helpful to predict patients with better response to treatment.
Hazardous properties and environmental effects of materials used in solar heating and cooling (SHAC) technologies: interim handbook (1978)

General background informaion related to SHAC systems, how a particular material was chosen for this handbook, and codes and standards are given. Materials are categorized according to their functional use in SHAC systems as follows: (1) heat transfer fluids and fluid treatment chemicals, (2) insulation materials, (3) seals and sealant materials, (4) glazing materials, (5) collector materials, and (6) storage media. The informaion is presented under: general properties, chemical composition, thermal degradation products, and thermoxidative products of some commercial materials; toxic properties and other potential health effects; fire hazard properties; and environmental effects of and disposal methods for SHAC materials. (MHR)
Abnormal Gene Expression Profiles in Human Ovaries from Polycystic Ovary Syndrome Patients (2004)

Polycystic ovary syndrome (PCOS) represents the most common cause of anovulatory infertility and affects 5-10% of women of reproductive age. The etiology of PCOS is still unknown. The current study is the first to describe consistent differences in gene expression profiles in human ovaries comparing PCOS patients vs. healthy normoovulatory individuals. The microarray analysis of PCOS vs. normal ovaries identifies dysregulated expression of genes encoding components of several biological pathways or systems such as Wnt signaling, extracellular matrix components, and immunological factors. Resulting data may provide novel clues for ovarian dysfunction in PCOS. Intriguingly, the gene expression profiles of ovaries from (long-term) androgen-treated female-to-male transsexuals (TSX) show considerable overlap with PCOS. This observation provides supportive evidence that androgens play a key role in the pathogenesis of PCOS. Presented data may contribute to a better understanding of dysregulated pathways in PCOS, which might ultimately reveal novel leads for therapeutic intervention.
Acoustical scattering by multilayer spherical elastic scatterer containing electrorheological layer (2011)

A computational procedure for analyzing acoustical scattering by multilayer concentric spherical scatterers having an arbitrary mixture of acoustic and elastic materials is proposed. The procedure is then used to analyze the scattering by a spherical scatterer consisting of a solid shell and a solid core encasing an electrorheological (ER) fluid layer, and the tunability in the scattering characteristics afforded by the ER layer is explored numerically. Tunable scatterers with two different ER fluids are analyzed. One, corn starch in peanut oil, shows that a significant increase in scattering cross-section is possible in moderate frequencies. Another, fine poly-methyl methacrylate (PMMA) beads in dodecane, shows only slight change in scattering cross-sections overall. But, when the shell is thin, a noticeable local resonance peak can appear near ka=1, and this resonance can be turned on or off by the external electric field.
Tangential Torque Effects on the Control of Grip Forces When Holding Objects With a Precision Grip (1997)

When we manipulate small objects, our fingertips are generally subjected to tangential torques about the axis normal to the grasp surface in addition to linear forces tangential to the grasp surface. Tangential torques can arise because the normal force is distributed across the contact area rather than focused at a point. We investigated the effects of tangential torques and tangential forces on the minimum normal forces required to prevent slips (slip force) and on the normal forces actually employed by subjects to hold an object in a stationary position with the use of the tips of the index finger and thumb. By changing the location of the object's center of gravity in relation to the grasp surface, various levels of tangential torque (0-50 N x mm) were created while the subject counteracted object rotation. Tangential force (0-3.4 N) was varied by changing the weight of the object. The flat grasp surfaces were covered with rayon, suede, or sandpaper, providing differences in friction in relation to the skin. Under zero tangential force, both the employed normal force and the slip force increased in proportion to tangential torque with a slope that reflected the current frictional condition. Likewise, with pure tangential force, these forces increased in proportion to tangential force. The effects of combined tangential torques and tangential forces on the slip force were primarily additive, but there was a significant interaction of these variables. Specifically, the increase in slip force for a given increment in torque decreases as a function of tangential force. A mathematical model was developed that successfully predicted slip force from tangential torque, tangential force, and an estimate of coefficient of static friction in the digit-surface interface. The effects of combined tangential torques and forces on the employed normal force showed the same pattern as the effects on the slip force. The safety margin against frictional slips, measured as the difference between the employed normal force and the slip force, was relatively small and constant across all tangential force and torque levels except at small torques (< 10 N x mm). There was no difference in safety margin between the digits. In conclusion, tangential torque strongly influences the normal force required for grasp stability. When controlling normal force, people take into account, in a precise fashion, the slip force reflecting both tangential force and tangential torque and their interaction as well as the current frictional condition in the object-digit interface.
HIV Vaccines: Progress, Limitations and a CRISPR/Cas9 Vaccine (2016)

Follow this and additional works at: http://digitalcommons.augustana.edu/biolstudent Part of the Biochemistry Commons, Biology Commons, Biotechnology Commons, Community Health and Preventive Medicine Commons, Genetics Commons, Genomics Commons, Immunity Commons, Immunology of Infectious Disease Commons, Immunopathology Commons, Immunoprophylaxis and Therapy Commons, Infectious Disease Commons, International Public Health Commons, Medical Genetics Commons, Medical Microbiology Commons, Medicinal Chemistry and Pharmaceutics Commons, Microbiology Commons, Molecular Biology Commons, Molecular, Cellular, and Tissue Engineering Commons, Molecular Genetics Commons, and the Pharmaceutics and Drug Design Commons
The effect of borage oil consumption on the composition of individual phospholipids in human platelets (1992)

The effect of supplementation with borage oil containing gamma-linolenic acid (GLA, 18:3n-6) on the levels and fatty acid compositions of individual human platelet phospholipids was evaluated. For this purpose, male volunteers were given an average daily intake of 5.23 g of GLA (as borage oil) for 42 days, after which the supplement was withdrawn for an additional 42-day period. No significant differences were found in the relative amounts of the choline phospholipids (PC), ethanolamine phospholipids (PE), phosphatidylserine (PS), phosphatidylinositol (PI), and sphingomyelin (SPH) at days 0, 22, 43, 64, and 85. However, marked differences were observed in the fatty acid compositions of all the phospholipids including a marked, and reversible, rise in the level of dihomo-gamma-linolenic acid (DGLA, 20:3n-6), without a significant elevation in arachidonic acid (AA, 20:4n-6) and decreases in n-3 polyunsaturated fatty acids. In the case of PC, a net rise in DGLA of 1.8 mol% was observed by day 22 (from 2.1 to 3.9 mol%). The DGLA/AA ratios at day 43 exhibited considerable variability across phospholipids with PC greater than PS greater than PE = PI; the PC, PE, PS, and PI accounted for 67.6, 16.7, 12.9, and 2.6%, respectively, of the total DGLA in platelet phospholipids. Interestingly, despite the lack of DGLA in SPH, this phospholipid exhibited a marked enrichment in nervonic acid (NA, 24:1n-9) from 16.2 to 24.7 mol% upon borage oil consumption. The observed alterations may represent biochemical strategies for adaptation to dietary fatty acid modifications and the regulation of platelet membrane functioning.
An approximation of the backhaul bandwidth aggregation potential using a partial sharing scheme (2017)

To cope with the increasing demands of mobile devices and the limited capacity of cellular networks, mobile connections are offloaded to WiFi. The access capacity is further increased by aggregating backhaul bandwidth of WiFi access links. To analyze the performance of aggregated access links we develop a model for two and more cooperating systems sharing capacities using an offloading scheme. The state probabilities of the different cooperating systems in the analytic model are determined by a fixed point iterative procedure. By investigating an inner and outer composite system we are able to analyze the system in imbalanced load conditions where the system reaches its full potential utilizing spare bandwidth. To evaluate the robustness of the system against users that try to exploit the system, the bandwidth received by prioritized users is quantified.
A biofuel cell in non-aqueous solution (2015)

We report the first example of a biofuel cell operating in organic solvents. The cell utilises glucose oxidase and bilirubin oxidase immobilised on nanoporous gold. The power output of the cell decreases with increasing solvent hydrophobicity in the alcohols, methanol (MeOH), ethanol (EtOH), 1-propanol (PrOH), 1-butanol (BuOH) and 1-pentanol (PeOH).
Assessment of Foreign Bridge Standards and Techniques (2004)

Chapter 3 Comparison of Turkish and American SpecificationsIn general, bridges are designed to higher loads in Turkey.Although AASHTO (1996) is being used, the GDH requires higher design live loads.Currently, the design load for highway bridges is HS20 or
Studies offer new insights into the characteristics of ADHD in adults (2012)

Abstract While children and adolescents have traditionally attracted much of the attention, recent studies offer new insights into the causes, consequences and treatment of ADHD in adults. Mark Greener reports.
Drop of Maturing Apples Associated with Bird Feeding1 (1967)

Abstract Further studies of bird damage on apples indicate that fruit dropping as a result of bird activities may be a greater economic loss than feeding damage. Since feeding wounds are caused during the fruit maturation period, the amount of dropped fruit resulting is directly related to two independent factors; first, the inherent ability of the variety to retain its fruit and second, the stage of fruit maturation when damage occurs.
A Cardiac-Specific Robotized Cellular Assay Identified Families of Human Ligands as Inducers of PGC-1α Expression and Mitochondrial Biogenesis (2012)

Using our cellular reporter assay we could identify three original families, able to activate mitochondrial biogenesis both in cell line and adult cardiomyocytes. This first screening can be extended to chemical libraries in order to increase our knowledge on PGC-1α regulation in the heart and to identify potential therapeutic compounds able to improve mitochondrial function in HF.