gebhart/patrepeval huggingface dataset:
Comparative evaluation of detection assays for chlamydia trachomatis (1991)

The performances of a commercial nucleic acid hybridization test (Gen-Probe Pace 2 Chlamydia trachomatis) and two commercial enzyme immunoassays (EIAs) (Abbott Chlamydiazyme and Pharmacia Chlamydia EIA) were evaluated against cell culture for the detection of C. trachomatis infection, with cervical swabs obtained from 1,037 women visiting a public sexual health center. The positivity rate by cell culture was 4.7%. Sensitivity and specificity for each test were as follows: Gen-Probe, 95.8 and 98.3%; Chlamydiazyme, 80.4 and 99.3%; Pharmacia EIA, 80.8 and 99.1%. Analysis of discrepant results with probe confirmation assay (Gen-Probe) and direct immunofluorescence (Syva Microtrak) revealed 12 cases of C. trachomatis infection for which culture was negative, resulting in the definition of a true-positive case as opposed to a culture positive. The positivity rate by true-positive definition was 5.9%, and sensitivity and specificity for each test were as follows: Gen-Probe, 96.7 and 99.6%; Chlamydiazyme, 77.5 and 100%; Pharmacia EIA, 77.0 and 100%; cell culture, 80.0 and 100%. We conclude that the Gen-Probe Pace 2 C. trachomatis test is a sensitive and specific alternative to cell culture for the detection of C. trachomatis.
Supplementary Methods and Figures Legends from Universal Marker and Detection Tool for Human Sarcoma Circulating Tumor Cells (2023)

&lt;p&gt;PDF file - 120KB&lt;/p&gt;
A series of two-dimensional microporous triazole-functionalized metal–organic frameworks with the new multi-dentate ligand 1-(4-aminobenzyl)-1,2,4-triazole: single-crystal-to-single-crystal transformation, structural diversity and luminescent sensing (2015)

A new flexible multi-dentate 1-(4-aminobenzyl)-1,2,4-triazole (abtz) ligand has been synthesized, and a series of two-dimensional triazole-functionalized metal–organic frameworks has been isolated.
Integrated Circuit Design in US High-Energy Physics (2013)

This whitepaper summarizes the status, plans, and challenges in the area of integrated circuit design in the United States for future High Energy Physics (HEP) experiments. It has been submitted to CPAD (Coordinating Panel for Advanced Detectors) and the HEP Community Summer Study 2013(Snowmass on the Mississippi) held in Minnesota July 29 to August 6, 2013. A workshop titled: US Workshop on IC Design for High Energy Physics, HEPIC2013 was held May 30 to June 1, 2013 at Lawrence Berkeley National Laboratory (LBNL). A draft of the whitepaper was distributed to the attendees before the workshop, the content was discussed at the meeting, and this document is the resulting final product. The scope of the whitepaper includes the following topics: Needs for IC technologies to enable future experiments in the three HEP frontiers Energy, Cosmic and Intensity Frontiers; Challenges in the different technology and circuit design areas and the related R&D needs; Motivation for using different fabrication technologies; Outlook of future technologies including 2.5D and 3D; Survey of ICs used in current experiments and ICs targeted for approved or proposed experiments; IC design at US institutes and recommendations for collaboration in the future.
From inverse design to implementation of practical (quantum) photonics (Conference Presentation) (2019)

Combining state-of-the-art optimization and machine learning techniques with high speed electromagnetic solvers offers a new approach to “inverse” design and implement classical and quantum photonic circuits with superior properties, including robustness to errors in fabrication and environment, compact footprints, novel functionalities, and high efficiencies. We illustrate this with a number of demonstrated devices in silicon, diamond, and silicon carbide, including wavelength and polarization splitters and converters, power splitters, couplers, nonlinear optical isolators, on chip laser driven particle accelerators, and efficient quantum emitter-photon interfaces.
MERCURY CONTROL WITH THE ADVANCED HYBRID PARTICULATE COLLECTOR (2003)

This project was awarded under U.S. Department of Energy (DOE) National Energy Technology Laboratory (NETL) Program Solicitation DE-PS26-00NT40769 and specifically addresses Technical Topical Area 4--Testing Novel and Less Mature Control Technologies on Actual Flue Gas at the Pilot Scale. The project team includes the Energy & Environmental Research Center (EERC) as the main contractor; W.L. Gore & Associates, Inc., as a technical and financial partner; and the Big Stone Plant operated by Otter Tail Power Company, host for the field-testing portion of the research. Since 1995, DOE has supported development of a new concept in particulate control called the advanced hybrid particulate collector (AHPC). The AHPC has been licensed to W.L. Gore & Associates, Inc., and is now marketed as the Advanced Hybrid{trademark} filter by Gore. The AHPC combines the best features of electrostatic precipitators (ESPs) and baghouses in a unique configuration, providing major synergism between the two collection methods, both in the particulate collection step and in the transfer of dust to the hopper. The AHPC provides ultra-high collection efficiency, overcoming the problem of excessive fine-particle emissions with conventional ESPs, and it solves the problem of reentrainment and re-collection of dust in conventional baghouses. The AHPC appears to have unique advantages for mercury control over baghouses or ESPs as an excellent gas-solid contactor. The objective of the original 5-task project is to demonstrate 90% total mercury control in the AHPC at a lower cost than current mercury control estimates. The approach includes bench-scale batch testing that ties the new work to previous results and links results with larger-scale pilot testing with real flue gas on a coal-fired combustion system, pilot-scale testing on a coal-fired combustion system with both a pulse-jet baghouse and an AHPC to prove or disprove the research hypotheses, and field demonstration pilot-scale testing at a utility power plant to prove scaleup and demonstrate longer-term mercury control. This project, if successful, will demonstrate at the pilot-scale level a technology that would provide a cost-effective technique to accomplish control of mercury emissions and, at the same time, greatly enhance fine particulate collection efficiency. The technology can be used to retrofit systems currently employing inefficient ESP technology as well as for new construction, thereby providing a solution to a large segment of the U.S. utility industry as well as other industries requiring mercury control. The scope of work was modified to include an additional sixth task, initiated in April 2003. The objective of this task is to evaluate the mercury capture effectiveness of the AHPC when used with elemental mercury oxidation additives and a spray dryer absorber and with novel baghouse sorbent inserts downstream of the fabric filter.
A Virulent Nosocomial Klebsiella with a Transferable R Factor for Gentamicin: Emergence and Suppression (1971)

Journal Article A Virulent Nosocomial Klebsiella with a Transferable R Factor for Gentamicin: Emergence and Suppression Get access Christopher M. Martin, Christopher M. Martin Search for other works by this author on: Oxford Academic PubMed Google Scholar Norman S. Ikari, Norman S. Ikari Search for other works by this author on: Oxford Academic PubMed Google Scholar Joy Zimmerman, Joy Zimmerman Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Allan Waitz J. Allan Waitz Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 124, Issue Supplement_1, December 1971, Pages S24–S29, https://doi.org/10.1093/infdis/124.Supplement_1.S24 Published: 01 December 1971
A novel method to optimize the wavelength for underwater free-space optical communications (2014)

Wirelessly transmitting large volumes of information at high data rates underwater is becoming increasingly important for such applications as environmental monitoring and petroleum exploration and maintenance. Underwater free-space optical (FSO) communication addresses the aforementioned need by providing wireless high-data-rate links. Visible light transmission through seawater typically peaks in the blue-green spectrum (475 nm–575 nm), but local clarity conditions, which are dynamic, strongly influence the actual maximum. We describe the development of a new laser-wavelength auto-selection algorithm and system for optimized underwater FSO communication. This system has the potential to improve underwater optical link reliability for high-data-rate communications. First, we describe the laser system and water tube setup for performing optical experiments. Next, we present research on recreating various seawater types (from clear to turbid) in the laboratory using particle suspensions and dye, which will enable wavelength-dependent transmission tests. Finally, we show experimental results from optical water tube tests, and describe the development of the autoselection algorithm.
Comparative Study of Fingerprint Database Indexing Methods (2019)

Nowadays, there are large country-sized fingerprint databases for identification, border access controls and also for Visa issuance procedures around the world. Fingerprint indexing techniques aim to speed up the research process in automatic fingerprint identification systems. Therefore, several preselection, classification and indexing techniques have been proposed in the literature. Even if, the proposed systems have been evaluated with different experimental protocols, it is difficult to assess their relative performance. The main objective of this paper is to provide a comparative study of fingerprint indexing methods using a common experimental protocol. Four fingerprint indexing methods, using naive, cascade, matcher and Minutiae Cylinder Code (MCC) approaches are evaluated on FVC databases from the Fingerprint Verification Competition (FVC) using the Cumulative Matches Curve (CMC) and the computing time required. Our study shows that MCC gives the best compromise between identification accuracy and computation time.
Structural Refinement of Insecticidal Plant Proteinase Inhibitors from Nicotiana alata (2008)

Ornamental tobacco (Nicotiana alata) produces a series of 6 kDa proteinase inhibitors belonging to the potato type II inhibitor family. These proteins inhibit trypsin and chymotrypsin, the main digestive enzymes of predatory insects, thus leading to starvation, impaired larval development or death. In this context, the three-dimensional structures of these inhibitors are important for developing novel strategies for pest control. The solution structures of C1 and T1, the two main prototypes of the N. alata inhibitors, were originally determined more than a decade ago (J. Mol. Biol. 242, 231-243 (1994) and Biochemistry 34, 14304-14311 (1995)). Since then methods for NMR structure calculations have evolved considerably. Here we report the refinement of the structures of C1 and T1 with state-of-the-art protocols for NMR structure calculations. This refinement leads to an improved quality of the structures, making them a more reliable basis for the development of novel pesticides and modeling applications.
TLC Characterization of Liposomes Containing Angiotensinogen, Angiotensine I, Angiotensine II and Saralazin (1997)

Recent studies have described intracellular binding sites for angiotensine II. In vascular smooth muscle it was found that intracellular injection of angiotensin II increases the Ca2+ level. An alternative method for intracellular delivery of drugs is represented by using liposomes. Thus, the aim of this study was to characterize liposomes filled with angiotensinogen, angiotensine I (Ang I), angiotensine II (Ang II), and saralasin by a TLC method and examine the physiological effects of these on rat vascular smooth muscle. Ang II (for all concentrations tested in the aqueous phase) and Ang I (for concentrations less than 10(-4)M) did not affect the thin-layer chromatography migration of this type of vesicle, suggesting that dose-dependent effects on physio-pharmacological experiments could be studied. On the other hand, this type of experiment could not be performed for salarasin- or angiotensinogen-filled liposomes. Administration of liposomes containing Ang II (10(-6)M), Ang I (10(-6)M), angiotensinogen (10(-6)M) and saralasine (10(-6)M) caused the contraction to isolated rat aorta smooth muscle, suggesting the presence of active intracellular binding sites.
Development and characterization of a high speed linear- moving-stage for multispectral measurements (2016)

Multispectral imaging is one of the key topics in the upcoming years, a lot of measurement tasks can be solved using the additional spectral information. For the separation of these additional information bands plenty technologies were developed in the last decades. All of them have characteristic advantages and disadvantages. One working principle is the use of a filter wheel containing different filters between the image sensor and the lens. The additional element inside the light propagation path as well as the lens imperfections lead to chromatic aberrations. To compensate the resulting focus error some investigation were made. One option is the movement of the image sensor stage to a better focus position. Therefore high precision moving stage with high movement speed are characteristic parameters which have to be considered during the construction. In this paper a linear motor stage paired with two high precision linear bearings were connected together to achieve the demanded requirements. For the evaluation of this new approach, several measurements determining the dynamic as well as the static specifications were made to proof the achieved characteristics and will be shown in the paper. With this approach, a miniaturised precision system inside the multispectral imager a precision repeatability of less than four microns can be achieved.
Changes in the Electrical Parameters of CdTe-based Crystals During Isothermal Annealing (2015)

We observed a novel unanticipated effect in CdTe, Cd <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> Zn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> Te and Cd <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> Mn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> Te crystals whilst we were measuring the dependences of several electrical properties (e.g., specific conductivity and free-carrier density) over time. During isothermal annealing under constant thermodynamic conditions (temperatures of 450- 500 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C and under maximal cadmium-vapor pressure), we recorded a jump-like increase in the conductivity after some ~ 1 - 2 hours of heating required to stabilize the sample's electric parameters. The values of specific conductivity and free-carrier density suddenly increased by up to tenfold, and they persisted at those levels during further ageing. At the same time, the sample's conductivity became insensitive to stoichiometric changes in the crystal. We explain this effect as reflecting a sudden reformatting of the sample's native/foreign point-defect structure. This transformation is evaluated and mathematically approximated within the framework of our model of the melting of Te-containing second-phase particles; this process releases impurities from within the particles. The respective diffusion “clouds” grow, and at the moment of their mutual percolation (infiltration), a peculiar “short circuit” is observed with striking changes in the crystals' electrical parameters.
Transforming growth factor-beta accelerates osteoinduction in a craniofacial onlay model. (1993)

Recombinant human transforming growth factor beta 1 was added to a demineralized bone matrix (DBM) paste, formed into cylinders and implanted onto the cranial periosteum of New Zealand White rabbits. The TGF-beta was added at doses of 0, 0.3, 3, 30 and 75 micrograms per implant. When the implants were removed after six weeks, histomorphometric analysis of the implants showed that TGF-beta induced significantly higher levels of trabecular bone formation than in the controls (mineralized bone area 6.0 +/- 0.8, 6.0 +/- 1.2, 5.6 +/- 1.0, 10.1 +/- 1.5, and 10.8 +/- 1.4 mm2, respectively, P < 0.05), TGF-beta also caused greater resorption of the demineralized bone matrix carrier (matrix area 7.2 +/- 0.9, 6.8 +/- 1.4, 3.7 +/- 0.9, 2.7 +/- 1.2, 0.9 +/- 0.5 mm2, respectively, P < 0.02). Measurements of the osteoid demonstrated a more active bone surface and there was evidence of rapid bone remodeling. Similar results were obtained using TGF-5 beta, a new hybrid molecule. These results demonstrate the capacity of transforming growth factor beta in accelerating osteoinduction.
Absorption spectra and conductivity of vacuum-deposited thin films of dyes. (1990)

種々の色素にっいて蒸着膜を作製し, その固体吸収スペクトルと導電性について検討した. その結果, 固体スペクトルは発色団の構造により大まかに五っのタイプに分類されることが分かった. また, X線粉末解析の結果から, ・ある種の色素では真空蒸着により単結晶と同じような結晶性の高い膜が得られることが分かった. 固体スペクトルは色素の会合性や互変異性や錯体の電荷移動によって影響を受ける. テトラアミノアントラキノン (TAAQ) -7, 7, 8, 8-テトラシアノキノジメタン (TCNQ) 錯体では, 溶液中で観測されるラジカル種による鋭い吸収が固体スペクトルでは消失することが分かった. この錯体の蒸着膜における導電性を種々のデバイスを作製することによって調べた結果, 膜面に平行な方向では半導体的挙動を示した. また, TAAQとTCNQを交互にnmオーダーの厚みで積層したヘテロ型の膜では50K以下の温度で絶縁体転位を起こした.
Hypodontia in patients with Down's syndrome. (1998)

The aim of this study was to assess the prevalence of hypodontia in subjects with Down's syndrome. A group of 112 subjects with cytogenetically confirmed diagnosis of Down's syndrome, aged 12-36 years were examined. Hypodontia of the permanent teeth has been established on the basis of dental examination and orthopantomogram analysis in all cases. Hypodontia was present in 38.6% patients. Upper lateral incisors were most commonly missing. In patients with Angle class I, hypodontia most frequently referred to upper left lateral incisors, upper left first premolars and lower left second premolars. In patients with Angle class II, lower second premolars and upper incisors were most commonly affected by hypodontia. In patients with Angle class III, hypodontic findings more frequently referred to the maxilla as compared to mandible.
ChemInform Abstract: Catalyst‐Controlled Regioselectivity in the Synthesis of Branched Conjugated Dienes via Aerobic Oxidative Heck Reactions. (2013)

Abstract The present regioselectivity is opposite to that traditionally observed for Heck reactions between a vinyl bromide and an alkene.
Exploratory Behavior, Cortical BDNF Expression, and Sleep Homeostasis (2007)

This study suggests a direct link between the synaptic plasticity triggered by waking activities and the homeostatic sleep response and identifies BDNF as a major mediator of this link at the molecular level.
Pena blanca natural analogue project: summary of activities (2010)

The inactive Nopal I uranium mine in silicic tuff north of Chihuahua City, Chihuahua, Mxico, was studied as a natural analogue for an underground nuclear-waste repository in the unsaturated zone.Site stratigraphy was confirmed from new drill cores.Data from site studies include chemical and isotopic compositions of saturatedand unsaturated-zone waters.A partial geochronology of uranium enrichment and mineralization was established.Evidence pertinent to uranium-series transport in the soil zone and changing redox conditions was collected.The investigations contributed to preliminary, scoping-level performance assessment modeling.
Ion beam synthesis of graphite and diamond in silicon carbide (2000)

A high dose of 1×1018 cm−2, 60 keV carbon ions was implanted into single crystalline 6H silicon carbide (SiC) at elevated temperatures. The formation of carbon phases in the crystalline SiC lattice was investigated by cross sectional transmission electron microscopy. An amorphous, carbon rich phase was produced at 300 °C. Precipitates of graphite were obtained at 600 °C, whereas at 900 °C small diamond grains were produced. These grains are in perfect epitaxial relation with the surrounding SiC lattice.
Bioerodible hydrogels based on 2‐hydroxyethyl methacrylate: Synthesis and characterization (2002)

Abstract Biocompatible polymers with specific shape and tailored hydrogel properties were obtained by polymerization of mixtures of 2‐hydroxyethyl methacrylate (HEMA) with 1–8 wt % ethylene glycol dimethacrylate (EGDMA) or tetra(ethylene glycol) diacrylate (TEGDA) as crosslinking agents, by using a redox initiator. Introduction of charged positive and negative groups was easily achieved by direct polymerization of appropriate monomer mixtures and by chemical transformation of preformed hydrogels. Investigation of the swelling behavior of the prepared hydrogels evidenced an appreciable dependence on both solvent type and polymer chemical structure. Additionally, the solvation process resulted in being controlled by solvent diffusion, according to a Fickian II mechanism. The presence of several types of water with different melting behavior was observed in fully swollen hydrogels. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 85: 2729–2741, 2002
Abstract TP137: Characteristics of Perfusion Profiles in Patients With Chronic Internal Carotid Artery Occlusion (2020)

Introduction: Internal carotid artery (ICA) occlusion may cause an acute stroke or may remain asymptomatic for years. Differences in the perfusion characteristics between patients with acute symptomatic ICA occlusions and those with chronic ICA occlusions have not been defined. The aim of this study is to identify the characteristics of the relatively “benign” perfusion pattern associated with chronic asymptomatic ICA occlusions and to determine if this pattern can be differentiated from the pattern observed in acutely symptomatic cases. Methods: We included 31 chronic ICA patients who had no history of a cerebral ischemic event for at least 1 year at the time of imaging and 20 patients with acute ischemic stroke caused by ICA occlusions from DEFUSE 2. All patients underwent MRI with perfusion. Perfusion parameters, including Tmax lesion volumes, hypoperfusion index (Tmax10/Tmax6), and CBV index (rCBV in Tmax6) were calculated by RAPID software. The status of the CBV, CBF, and MTT in the ischemic hemisphere was also rated by visual inspection on a 3-point scale (unchanged, reduced or increased). Differences were assessed by Mann-Whitney and Fisher’s exact tests. Results: The average age was 65.0±9.9 years in chronic vs. 64.7±14.2 years in acute ICA occlusion group ( p =0.90). Most of the chronic ICA patients had no territory with Tmax&gt;10s (29/31) or Tmax&gt;8s (24/31) in the ischemic hemisphere. The average Tmax lesion volumes were lower in the chronic ICA group (Tmax&gt;6 of 14 ml and Tmax&gt;4 of 81 ml) than in the acute ICA occlusion group (Tmax&gt;6 of 131 ml and Tmax&gt;4 of 220 ml, p &lt;0.0001 for both, Figure). CBV was unchanged in all chronic occlusion cases. In the acute occlusion group, there were 12 out of 20 cases (60%) with decreased CBV ( p &lt;0.0001). CBF was decreased in 1 (3%) patient with a chronic occlusion and 17 cases (85%) with acute occlusions ( p &lt;0.0001). MTT prolonged in 7 cases (22%) with chronic occlusions vs. all cases (100%) with acute occlusions ( p &lt;0.0001). Conclusions: Several features on perfusion MRI distinguish chronic ICA occlusions from acute occlusions. Patients with chronic ICA occlusions tend to have none or a minimal volume of tissue with Tmax&gt;8s or &gt;10s delay, smaller volumes of tissue with Tmax&gt;4s and &gt;6s delay, and normal appearing CBV and CBF maps.