gebhart/patrepeval huggingface dataset:
[Absence of nephro-protective effect of acetylcysteine in patients with chronic renal failure investigated by coronary angiography]. (2003)

Recent studies have suggested that an oral dose of acetylcysteine could play a prophylactic role in the prevention of nephrotoxicity from iodine contrast media in patients affected by chronic renal failure. Between June 2001 and September 2002 we selected 120 patients with a basal plasma creatinine level greater than 1.36 mg/dl investigated by coronary angiography. The treatment group included 60 patients who received 600 mg of acetylcysteine in the morning and evening before the day of the examination together with intravenous saline hydration. The control group patients received hydration alone. The clinical characteristics of the groups were comparable as well as the basal plasma creatinine level: 2.01+/-1.1 mg/dl in the acetylcysteine group and 1.81+/-0.69 in the control group. The plasma creatinine level was measured 24 and 48 hours after coronary angiography. The respective changes in plasma creatinine level at 24 and 48 hours were 0.12+/-0.29 and 0.02+/-0.29 mg/dl in the acetylcysteine group and 0.06+/-0.29 and 0.07+/-0.43 mg/dl in the control group (NS). Acute renal failure caused by the contrast medium, defined by an increase of 25% in the plasma creatinine level compared to the basal value, occurred in 3 patients from the acetylcysteine group and 2 patients from the control group. The only predictive factor for acute renal failure was the quantity of contrast medium (316+/-141 vs 173+/-115 ml, p<0.05). In conclusion, acute renal failure caused by contrast medium is rare in sufficiently hydrated patients with moderate chronic renal failure when a low dose of contrast medium is used. Our study does not confirm a prophylactic effect of acetylcysteine in the prevention of nephrotoxicity from contrast media following coronary angiography in patients with moderate chronic renal failure.
Animal trials of a Magnetically Levitated Left-Ventricular Assist Device (2000)

The University of Pittsburgh/Magnetic Moments mag-lev left-ventricular assist devices (LVADs), the Streamliner HG3b and HG3c, have successfully been implanted in calves. The first was implanted for 4 hours on July 10, 1998 and the second for 34 days on August 24, 1999 respectively. The tests confirmed the feasibility of low power levitation (1.5 watts coil power) and very low blood damage in a mag-lev ventricular assist device. In this paper, we describe the unique geometry of this pump and its design. Key features of this LVAD concept are the passive radial suspension and active voice-coil thrust bearing.
Bi-stable luminescence properties of indium-cerium-based fluorides (2018)

Invited talk
Über die Synthese von Quercetin‐3‐glykosiden, IV. Synthese des Quercetin‐ und Kämpferol‐3‐β‐gentiobiosids (1968)

Abstract Ausgehend von 7.4′‐Dibenzyl‐quercetin bzw. ‐kämpferol wurden durch Umsetzung mit α‐Acetobromgentiobiose nach Königs‐Knorr Quercetin‐ und Kämpferol‐3‐β‐gentiobiosid als erste synthetisierte Gentiobioside dargestellt und damit der endgültige Strukturbeweis für die natürlich vorkommenden Glykoside geliefert.
Changes in Oxidative Phosphorylation Activity in Fibroblasts at p38 MAPK Pathway Inhibition (2019)

Background: Mitochondrial oxidative phosphorylation (OxPhos) accounts for more than 90% of the cellular ATP production, plays the role in reactive oxygen species (ROS) generation and programmed cell death. In addition, it contributes to such cellular processes as proliferation, differentiation and cell aging. Currently, several signaling systems are known to participate in regulation of OxPhos and activity of cytochrome c-oxidase (CcO), the terminal enzyme of the mitochondrial electron transport chain. However, data on mechanisms and key units involved in the signal transduction are still being supplemented.
J0450301 Ultrasonic Image by Manual Scanning UT Technique (2014)

This paper introduces a new real-time image ultrasound technique for thin-wall structure in which the scanning of the ultrasound transmitter is carried out by hand. By this technique, we can get the ultrasound-image without a scanner or an encoder, and test a thin-wall structure faster than by ultrasonic pulse-echo method. Existence or nonexistence of defects is estimated by monitoring the amplitude-ratio of A_0 mode to S_0 mode of lamb wave between the ultrasound transmitter and the receiver. In addition, the image is constructed by determining the transmitter position (x,y) by source location method. The damaged image was successfully constructed for a thinning made on Aluminum plate by proposed method.
NSP-encoded reticulons, neuroendocrine proteins of a novel gene family associated with membranes of the endoplasmic reticulum (1994)

The novel NSP gene was previously shown to encode, among a variety of neuroendocrine cell types, two 3'-overlapping transcripts, a 3.4 kb one for NSP-A (776 amino acids) and a 1.8 kb one for NSP-C (208 amino acids). The deduced proteins, which were predicted to possess distinct amino-terminal regions, appeared to exhibit some architectural resemblance to known neuroendocrine proteins. In this paper the biochemical characterization and subcellular localization of the two proteins is addressed. In vitro translation of NSP-A and -C RNA produced proteins of about 135 and 23 kDa, respectively. Proteins of similar molecular mass were also detected in immunoprecipitation and western blot analyses of neural and endocrine cells using specific anti-NSP-A or -C antisera; some heterogeneity of NSP-A was observed. NSP-A, but not NSP-C, appeared to be highly phosphorylated and preferentially on serine residues. In immunocytochemical studies, we demonstrated that NSP-A and -C are associated with the endoplasmic reticulum; NSP-A was found to co-localize with SERCA2b, a membrane-associated Ca(2+)-ATPase of the endoplasmic reticulum. In Purkinje cells, we found NSP-immunostaining in the perikaryon, the extensive dendritic tree and the axon, also suggesting association with the smooth endoplasmic reticulum. Biochemical studies of NSP-A provided evidence that NSP-A is strongly associated with microsomal membranes and analysis of deletion mutants of NSP-A revealed that the hydrophobic carboxy-terminal portion of the protein, which is also present in NSP-C, is critical for membrane binding. Through database searches, finally, we found two different NSP-related sequences, one in a sequenced region of human chromosome 19, and the second in a human, pancreatic islet-derived partial cDNA, suggesting that the NSP gene is the prototype of a larger gene family. The results of our studies seem to indicate that the NSP-encoded proteins are novel, membrane-anchored components of the endoplasmic reticulum for which we propose the name reticulons.
Finding the Perfect Match: A Combined Computational and Experimental Study toward Efficient and Scalable Photosensitized [2 + 2] Cycloadditions in Flow (2018)

With ever-evolving light-emitting diode (LED) technology, classical photochemical transformations are becoming accessible with more efficient and industrially viable light sources. In combination with a triplet sensitizer, we report the detailed exploration of [2 + 2] cycloadditions, in flow, of various maleic anhydride derivatives with gaseous ethylene. By the use of a flow reactor capable of gas handling and LED wavelength/power screening, an in-depth optimization of these reactions was carried out. In particular, we highlight the importance of matching the substrate and sensitizer triplet energies alongside the light source emission wavelength and power. Initial triplet-sensitized reactions of maleic anhydride were hampered by benzophenone’s poor absorbance at 375 nm. However, density functional theory (DFT) calculations predicted that derivatives such as citraconic anhydride have low enough triplet energies to undergo triplet transfer from thioxanthone, whose absorbance matches the LED emission at 375 nm. This observation held true experimentally, allowing optimization and further exemplification in a larger-scale reactor, whereby >100 g of material was processed in 10 h. These straightforward DFT calculations were also applied to a number of other substrates and showed a good correlation with experimental data, implying that their use can be a powerful strategy in targeted reaction optimization for future substrates.
Source Identification Using Signal Characteristics in Controller Area Networks (2014)

The CAN (Controller Area Network) bus, i.e., the de facto standard for connecting ECUs inside cars, is increasingly becoming exposed to some of the most sophisticated security threats. Due to its broadcast nature and ID oriented communication, each node is sightless in regards to the source of the received messages and assuring source identification is an uneasy challenge. While recent research has focused on devising security in CAN networks by the use of cryptography at the protocol layer, such solutions are not always an alternative due to increased communication and computational overheads, not to mention backward compatibility issues. In this work we set steps for a distinct approach, namely, we try to take authentication up to unique physical characteristics of the frames that are placed by each node on the bus. For this we analyze the frames by taking measurements of the voltage, filtering the signal and examining mean square errors and convolutions in order to uniquely identify each potential sender. Our experimental results show that distinguishing between certain nodes is clearly possible and by clever choices of transceivers and frame IDs each message can be precisely linked to its sender.
Statechart methodology for the design, validation, and synthesis of large scale asynchronous systems (2002)

We apply a novel methodology, based on statecharts, for the design of large scale asynchronous systems. The EXV CAD tool offers specification at multiple levels, simulation, animation, and compilation into synthesizable VHDL code. EXV has some verification capabilities, and we add a validation sub-system EXV is originally synchronous, but we discuss how to employ it for asynchronous design. The tool is demonstrated through a simple FSM.
CONCENTRATION GRADIENTS FOR RADIOIODIDE IN UNBLOCKED THYROID GLANDS OF RATS: EFFECTOF PERCHLORATE1 (1956)

THE iodide-trapping mechanism of the thyroid provides a concentrated substrate for subsequent organic iodinations within the gland. Obliteration of this function, by anions such as thiocyanate or perchlorate, results in diminished formation of hormone, goiter, and myxedema (Barker, 1936; Astwood, 1943; Rawson, Tannheimer and Peacock, 1944; Wolff et al., 1946; VanderLaan and VanderLaan, 1947; Wyngaarden, Wright, and Ways, 1952). Under conditions of blockade to organic binding, external counting techniques in man have repeatedly demonstrated within the gland concentrated radioiodide which can readily be discharged by thiocyanate or perchlorate (Stanley and Astwood, 1948; Stanbury and Wyngaarden, 1952). Similar attempts to demonstrate dischargeable thyroidal radioiodine have met with variable succees when organic-binding has been allowed to proceed (Kirkland, 1954; Berson and Yalow, 1955; Ingbar, 1955; VanderLaan, 1955). Several investigators, having been unable consistently to demonstrate dischargeable radioiodine under the latter conditions, have concluded that organic-binding of concentrated iodide is virtually instantaneous (Berson and Yalow, 1955; VanderLaan, 1955).
Balloon Technique for Treatment of Frontal Sinus Fractures (1967)

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Binary Classification from Positive-Confidence Data (2017)

Can we learn a binary classifier from only positive data, without any negative data or unlabeled data? We show that if one can equip positive data with confidence (positive-confidence), one can successfully learn a binary classifier, which we name positive-confidence (Pconf) classification. Our work is related to one-class classification which is aimed at "describing" the positive class by clustering-related methods, but one-class classification does not have the ability to tune hyper-parameters and their aim is not on "discriminating" positive and negative classes. For the Pconf classification problem, we provide a simple empirical risk minimization framework that is model-independent and optimization-independent. We theoretically establish the consistency and an estimation error bound, and demonstrate the usefulness of the proposed method for training deep neural networks through experiments.
O5: THE CLIFF AND CONOR STUDIES NOVEL ASSESSMENT TOOLS IN COLORECTAL LIVER METASTASES (CLIFF STUDY - CHANGE IN LIVER FUNCTION AND FAT IN PRE-OPERATIVE CHEMOTHERAPY FOR COLORECTAL LIVER METASTASES, CONOR STUDY (2021)

Abstract Introduction Hepatic resection is the only potentially curative treatment for patients with colorectal liver metastases (CLM). Patient selection is key, but there is wide variation in practice. Pre-operative chemotherapy can improve oncological outcomes, however chemotherapy-associated liver injury (CALI) may hinder liver regenerative capacity. Standard pre-operative assessments fail to accurately capture factors such as CALI and future liver remnant (FLR) function. The CLiFF and CoNoR studies utilise two novel assessment techniques, aiming to improve patient outcomes. Method The CLiFF study prospectively assesses two primary outcomes in 35 patients undergoing pre-operative chemotherapy for CLM: 1) change in liver function (via LiMAx test: direct assessment of hepatic functional capacity), and 2) change in liver fat (via advanced MR imaging (in-house spectroscopy and modified Dixon technique, scaled up via Perspectum LiverMultiScan)). The CoNoR study assesses potential added benefit of these novel tools in CLM resectability decision-making via sequential workstreams: a systematic review and international hepatobiliary expert interviews inform the online survey, assessing added benefit via online MDT scenarios. Result Preliminary CLiFF analysis suggests that CALI changes in liver fat and function are unrelated. Liver fat analysis techniques are compared and correlated with digital histological analysis. The CoNoR systematic review identifies key factors influencing CLM resectability decision-making and informs the international expert interviews, scheduled to occur during a February 2020 international hepatobiliary conference. Conclusion These studies are the first to assess where these novel tools might be utilised to maximal patient benefit within the Hepatobiliary MDT, and the first systematic review in CLM resectability decision-making. Take-home message These two linked studies evaluate the use of two novel assessment tools in the treatment of colorectal liver metastases, with the potential to improve patient selection for curative resection and patient outcomes. PATEY PRIZE SESSION
A model for strengthening of Al-Cu-Mg alloys by S phase (2003)

An age hardening model has been developed to predict the yield strength of Al-Cu-Mg alloys with composition within the a+S phase field of the phase diagram. The model describes the microstructure evolution and strengthening of these alloys by considering the formation and dissolution of two types of precipitates: S phase and pre-precipitates in the form of clusters. Strengthening caused by clusters and S phase is described by the modulus strengthening mechanism and the Orowan (precipitate by-passing) mechanism, respectively. The model contains a new, relatively simple treatment for the precipitation kinetics of S phase, which includes a progressive transition from the nucleation/growth regime to the coarsening regime. The model predictions are in good agreement with the measured yield strengths of a solution treated, stretched and subsequently aged Al-Cu-Mg alloy, and all model parameters are either entirely predictable or physically reasonable. The modelling accuracy on unseen data is about 10MPa. Combined with previous 3DAP results, analysis of DSC and TEM results of these alloys show that the main precipitates were S phase and its precursor in the form of clusters, which is consistent with the model. A semi-quantitative analysis of the evolution of the S phase formation effect in DSC experiments on samples aged for a range of ageing times is also consistent with model predictions.
ChemInform Abstract: METHYL‐TERT.‐BUTYL‐CARBODIIMID, EINE VERBINDUNG ZUR CHARAKTERISIERUNG VON (2+2)‐CYCLOADDITIONSRK. (1972)

Abstract Bei der Umsetzung von Phenylisocyanat (I) mit dem Carbodiimid (II) entsteht das Produkt (III), dessen Struktur aufgrund der Thermolyseprodukte (IV) und (V) abgeleitet wird.
Paragonimus Kellicotti Ward, 1908, in Feral Ohio Mink (1970)

Author Institution: Department of Biological Sciences, Kent State University, Kent, Ohio 44240
Segmental Renal Artery Stenosis in Renovascular Hypertension (1968)

The importance of main renal artery stenosis as a cause of human hypertension is well recognized. Stenoses of renal artery branches may also cause hypertension, but the incidence of such stenoses and the frequency with which they are etiologically related to hypertension receive little comment in the literature. Involvement of segmental renal arteries was reported by Harrison et al. (11, 12) in 56 per cent of patients with fibromuscular disease, and by Meaney and Dustan (14) in 58 per cent of patients with atherosclerotic renovascular disease. These authors did not attempt to assess the severity or hemodynamic significance of the stenoses. The present paper reports the author's experience with segmental renal artery stenoses in renovascular hypertension. Objective morphologic observations will be presented initially. In the discussion that follows, several hypotheses regarding the hemodynamic significance of these lesions will be proposed. Certain definitions must be clarified at the outset: A. Segmental renal artery: a parenchymal branch of a renal artery larger than an arcuate artery, including vessels that Boijsen (3) refers to as primary ventral and dorsal rami, and segmental, subsegmental, and interlobar arteries. As used here, the term does not include accessory renal arteries arising from the aorta. B. Hemodynamically significant stenosis: a stenosis which decreases transstenotic blood flow or poststenotic blood pressure, or both. For a renal artery stenosis to produce renovascular hypertension, it must be of hemodynamic significance (4). The corollary, however, is not necessarily true, i.e., a hemodynamically significant stenosis need not produce renovascular hypertension. Case Material From January 1964 through September 1967 more than 400 renal arteriographic studies were performed at the University of Michigan Medical Center for evaluation of renovascular hypertension. Most of the examinations were carried out by percutaneous catheterization, with intra-aortic and selective injections of contrast medium. From these studies, 45 patients with segmental renal artery disease were recognized. The diagnoses were: (a) atherosclerosis (14 cases); (b) fibromuscular disease (11 cases); (c) renal infarct (14 cases); (d) miscellaneous—pyelonephritis (5 cases) and probable arteritis of unknown type (1 case). I. Analysis According to Diagnosis A. Atherosclerotic Segmental Stenoses: Atherosclerotic segmental stenoses were visible in 19 kidneys in 14 patients. Eleven of the patients were from a group of 29 with moderate or marked atherosclerosis of the main renal artery, but in 3 cases of segmental disease there was no associated main artery disease. All but one had obvious atherosclerosis of the aorta. An upper pole segmental vessel was involved in 8 cases, dorsal branches to the lower pole in 3 (Fig. 1), and multiple or ventral branches in 9.
Construction of novel Ag/HKUST-1/g-C3N4 towards enhanced photocatalytic activity for the degradation of pollutants under visible light (2019)

A novel Ag/metal-organic framework/graphitic carbon nitride (Ag/HKUST-1/g-C<sub>3</sub>N<sub>4</sub>, AHC) photocatalyst was prepared <i>via</i> an <i>in situ</i> growth strategy and photo-deposition technique for environmental remediation. The as-obtained samples were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), N<sub>2</sub> adsorption-desorption isotherm measurement, UV-vis diffuse reflection spectroscopy (UV-vis DRS), and photoluminescence (PL) spectroscopy. The results indicated that the hybrids have large surface area, mesoporous structure and enhanced visible-light absorption. The as-prepared hybrid samples exhibited considerable improvement in photocatalytic activity and stability for rhodamine B (RhB) degradation under visible light irradiation (<i>λ</i> > 420 nm). In addition, they also have good adsorption properties. Compared to the pure g-C<sub>3</sub>N<sub>4</sub> and Ag/g-C<sub>3</sub>N<sub>4</sub>, the 5% AHC photocatalyst showed superior photocatalytic activity. Moreover, 5% AHC exhibits good photocatalytic activity even after four cycles. Additionally, the active species trapping and electron spin resonance (ESR) experiments indicated that h<sup>+</sup> and ·OH were the main active species.
TALEN-mediated genome-editing approaches in the liverwort Marchantia polymorpha yield high efficiencies for targeted mutagenesis (2017)

Considering time, costs and practicability, the assembly TALEN approach represents a rapid and highly efficient gene targeting system to generate Marchantia knockout mutants, which can be further adapted for future advanced genome-editing applications.
Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids (2017)

Using an integrated metabolomic workflow, this study identified a link between cholesterol sulfate and phospholipids, metabolic characteristics of the metastatic niche, and the capacity of tumor cells to colonize distant sites.
Imbalance-Voltage Mitigation in an Inverter-Based Distributed Generation System Using a Minimum Current-Based Control Strategy (2019)

Voltage imbalances are one of the most severe challenges in electrical networks, which negatively affect their loads and other connected equipment. This paper proposes a voltage support control strategy to mitigate the voltage imbalance in inverter-based low voltage distribution networks. The control scheme is derived taking in mind the following control objectives: a) to increase the positive sequence voltage as much as possible, b) to decrease the negative sequence voltage as much as possible, c) to inject the power generated by the primary source, and d) to minimize the output current of the inverter. The innovative contribution of the proposed solution is based on the design of a control algorithm that meets the aforementioned objectives without resorting to communications with other grid components. The theoretical results are experimentally validated by selected tests on a laboratory setup with X/R ratio close to one.