gebhart/patrepeval huggingface dataset:
Deconvolution Fluorescence Light Microscopy (2002)

Abstract Deconvolution microscopy is a computational technique that deblurs fluorescence images using knowledge of the optical path of the microscope.
Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism (2017)

Direct acting antivirals against hepatitis C virus (HCV) have markedly improved cure rates in the past few years. However, they are expensive, with only few targeting host cell factors, and affecting virus assembly and release. Huh7.5 cells infected with a JFH-1 clone of HCV were treated with two different glycogen synthase kinase (GSK3)-β inhibitors; AR-A014418 and lithium chloride. Intra- and extracellular HCV virions and specific infectivity was determined using real-time RT-PCR and TCID50, and changes in lipid production were identified by enzyme-linked immunoassay and mass spectrometry analyses. Similarly, effect on two HCV replicon cells were identified by the luciferase activity. Although there was limited effect on virus replication in Huh7.5 cells and replicons, Huh7.5 cells treated with GSK3β inhibitors produced significantly less viral particles in comparison to untreated cells. In addition, the treated cells synthesized significantly lower amounts of ApoB and trapped the ApoE lipoproteins in the cells. In conclusion, our study suggests that GSK3β plays a pivotal role in HCV virion assembly and release mediated in part through inhibition of apolipoprotein synthesis.
Automatic TV Broadcast Structuring (2010)

TV broadcast structuring is needed to precisely extract long useful programs. These can be either archived as part of our audio-visual heritage or used to build added-value novel TV services like TVoD or Catch-up-TV. First, the problem of digital TV content structuring is positioned. Related work and existing solutions are deeply and carefully analyzed. This paper presents then DealTV, our fully automatic system. It is based on studying repeated sequences in the TV stream in order to segment it. Segments are then classified using an inductive logic programming-based technique that makes use of the temporal relationships between segments. Metadata are finally used to label and extract programs using simple overlapping-based criteria. Each processing step of DealTV has been separately evaluated in order to carefully analyze its impact on the final results. The system has been proven on a real TV stream to be very effective.
Seeking Mass Market Acceptance for High‐Technology Consumer Products (1992)

Discusses the various strategies for mass merchandizing technologically complex products and services. Considers fear of technology, high‐tech aficionados, and lifestyle differences as factors in marketing high‐tech goods. Concludes that separate strategies for aficionados and non‐aficionados should be developed, and also that more customer‐oriented strategies should take into account that the aficionados themselves can be segmented by interests.
Quantitative Analysis of Soluble Cell Adhesion Molecules in Otitis Media with Effusion (1994)

The levels of the soluble intercellular adhesion molecule 1 (sICAM-1) and soluble granule membrane protein-140 (sGMP-140) were measured in middle ear effusions (MEEs) of otitis media (OM) with ELISA. MEEs of chronic serous and mucoid OM in children contained significantly higher levels of sICAM-1 and sGMP-140 compared with normal serum. sGMP-140 in acute and chronic OM in children was higher than in adult chronic serous OM, and in acute purulent OM higher chronic serous OM in children. Cytologic analysis showed that the mean level of sGMP-140 was significantly higher in the neutrophil dominant group than in other groups except the few cells type. sICAM-1 showed no differences among the cytologic classifications. Copious amounts of sICAM-1 and sGMP-140 in MEEs were observed in this study, and were probably the result of shedding from the cells expressed cell adhesion molecules. These cell adhesion molecules in MEEs were thought to modify the inflammatory response in OM.
A Data Fusion Method For Improved Motion Estimation (2015)

Publication in the conference proceedings of EUSIPCO, Tampere, Finland, 2000
Enantioselective Synthesis of 3-Substituted Indolines by Asymmetric Intramolecular Carbolithiation in the Presence of (−)-Sparteine (2000)

published
Trypanosoma cruzi variants with reduced virulence obtained by mutagenesis (1984)

Previous reports have indicated that by mutagen treatment of mouse tumour cells in vitro it is possible to obtain at high frequency stable tumour cell variants that fail to form tumours in syngeneic mice because of increased immunogenicity. By analogy with these tumour cell variants, we examined whether variants with reduced virulence could be obtained by mutagen treatment of trypomastigotes derived from a Trypanosoma cruzi strain that was adapted to culture and produced lethal infections in DBA/2 mice at a dose of 5 X 10(4) parasites. A very large frequency of T. cruzi clones were obtained that failed to provoke an acute lethal infection after injection of 5 X 10(5) parasites. Most of these variants with reduced virulence (vir-) multiplied actively in normal mice until day 8 after injection. After that time the parasitaemia decreased gradually. For most variants a low level of residual parasitaemia persisted for more than 100 days. Unlike the situation encountered with mouse tumour cell variants it was not possible to demonstrate the presence of new antigens on the T. cruzi vir- variants. However, these variants seemed to have acquired an increased immunogenicity since they provoked the rejection of virulent parasites injected concomitantly. Mice that had been immunized with living vir- clones were protected against a challenge with a virulent clone derived from the original parasite population.
Machine-learning-enabled optimization of atomic structures using atoms with fractional existence (2023)

We introduce a method for global optimization of the structure of atomic systems that uses additional atoms with fractional existence. The method allows for movement of atoms over long distances bypassing energy barriers encountered in the conventional position space. The method is based on Gaussian processes, where the extrapolation to fractional existence is performed with a vectorial fingerprint. The method is applied to clusters and two-dimensional systems, where the fractional existence variables are optimized while keeping the atomic positions fixed on a lattice. Simultaneous optimization of atomic coordinates and existence variables is demonstrated on copper clusters of varying size. The existence variables are shown to speed up the global optimization of large and particularly difficult-to-optimize clusters.
The Flooring for Injury Prevention (FLIP) Study of compliant flooring for the prevention of fall-related injuries in long-term care: A randomized trial (2019)

ClinicalTrials.gov: NCT01618786.
Imiquimod in the treatment of multifocal vulvar intraepithelial neoplasia 2/3. Results of a pilot study. (2002)

This pilot study showed the potential beneficial effect of imiquimod 5% cream in multifocal VIN 2/3. In contrast to current surgical treatment, imiquimod focuses on the cause of VIN and preserves the anatomy and function of the vulva. Therefore, imiquimod may prove to be the treatment of choice in multifocal, high grade VIN.
The BAFF/APRIL System in Systemic Autoimmune Diseases with a Special Emphasis on Sjögren's Syndrome (2005)

Systemic autoimmune diseases, such as Sjögren's syndrome (SS), are characterized by a complex aetiology with multiple pathogenic factors. In SS, disturbed B-cell biology and humoral immunity including B-cell-activating factor (BAFF)-mediated processes have been described. Dysregulated BAFF expression has been described to lead to disease progression and perpetuation of humoral autoimmunity. Moreover, BAFF has been proposed to contribute to the development of B-cell malignancies. In this review, we summarize the current knowledge on BAFF with regard to SS pathology and discuss special features such as germinal centre (GC) formation and lymphomagenesis. Locally, in SS salivary glands, the reduced level of apoptosis among BAFF-expressing cells might lead to longer-existing BAFF expression and thereby maintain signalling for tissue-infiltrating B cells to proliferate and supposedly to become autoantibody-producing plasma cells. We assume that prolonged BAFF signalization may contribute to GC formation and/or lymphoma development in the disease. Finally, we discuss possibilities of novel treatments targeting the BAFF-system in SS.
Fundamental interface properties in OFETs: Bonding, structure and function of molecular adsorbate layers on solid surfaces (2008)

Abstract The functionality of organic field effect transistors resides in their interfaces. Highly ordered molecular adsorbate layers provide an excellent tool to study the relevant physical properties of these interfaces. In this article we focus on molecules at the organic/metal interface. We find that their geometry and electronic structure are very responsive to influences from the substrate and the molecular environment, while interface structures evolve cooperatively in the sway of interfacial and intermolecular interactions and can thus be extremely complex. Although our results cannot be transferred directly to real devices, a number of intriguing physical effects emerge that could play an important role in (nanoscale) OFETs, e.g. an anomalously strong energy band dispersion at the organic/metal interface, a remarkable plasticity of the electronic structure of molecules in ultra‐thin films, and Kondo physics in a non‐magnetic molecular wire. Finally, we report the realization of a mechanically gated single‐molecule transistor that allows investigating the transport physics in a molecular wire as a function of contact properties. (© 2008 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
A Comparison of Retrieval Models using Term Dependencies (2014)

A number of retrieval models incorporating term dependencies have recently been introduced. Most of these modify existing "bag-of-words" retrieval models by including features based on the proximity of pairs of terms (or bi-terms). Although these term dependency models have been shown to be significantly more effective than the bag-of-words models, there have been no previous systematic comparisons between the different approaches that have been proposed. In this paper, we compare the effectiveness of recent bi-term dependency models over a range of TREC collections, for both short (title) and long (description) queries. To ensure the reproducibility of our study, all experiments are performed on widely available TREC collections, and all tuned retrieval model parameters are made public. These comparisons show that the weighted sequential dependence model is at least as effective as, and often significantly better than, any other model across this range of collections and queries. We observe that dependency features are much more valuable in improving the performance of longer queries than for shorter queries. We then examine the effectiveness of dependence models that incorporate proximity features involving more than two terms. The results show that these features can improve effectiveness, but not consistently, over the available data sets.
Editing Interchangeability of the Narrow Track Digital VTR. (1992)

Editing interchangeability is one of the most important factors in narrow-track digital VTRs for broadcast use. The worst degradation of the recording foot print occurs during insert editing . This work investigates all factors that can lead to format errors. Several new technologies , such as a head pair configuration, a distinctive audio sector arrangement, using a guard band only at the editing point and so on, are proposed as ways to reduce the influences of these errors . Moreover, a new definition for the tolerance zones of helical tracks is recommended.
Packing material activity in packed capillary column SFC (1990)

Abstract Several commercially available and home‐made reversed phase packing materials packed in capillary columns are evaluated for SFC with pure CO 2 as mobile phase. Anilines and polycyclic aromatic hydrocarbons are used as test mixture. Some “on column endcapping” experiments are evaluated.
Painless Pediatric Priapism and Cough (2014)

Pediatric priapism can be a medical emergency but is not a common complaint seen in pediatric emergency department. Priapism in a previously healthy child is also rare. We report a case of painless stuttering priapism associated with an acute Mycoplasma pneumoniae infection in a previously healthy boy.
Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. (1990)

The induction of cachectin/tumor necrosis factor (TNF) synthesis by bacterial endotoxins is a process that entails activation at several levels. Cachectin/TNF gene transcription is accelerated, leading to rapid accumulation of mRNA within the macrophage cytosol. In addition, translational derepression occurs, leading to far more efficient message utilization. Through the use of posttranscriptional reporter constructs, we now demonstrate that certain agents capable of inhibiting cachectin/TNF biosynthesis operate through different mechanisms. In RAW 264.7 macrophages, pentoxifylline blocks cachectin/TNF mRNA accumulation but has no effect upon the efficiency of reporter mRNA translation. Dexamethasone, on the other hand, has only a modest effect on cachectin/TNF mRNA accumulation, but strongly impedes translational derepression. Combined application of dexamethasone and pentoxifylline to macrophages causes a greater suppression of cachectin/TNF biosynthesis that can be achieved by either agent alone. These findings suggest that the signaling pathway activated by endotoxin is branched, and that selective inhibition of different parts of the pathway may be achieved through the use of distinct agents.
A dielectric rod antenna driven by a pulsed power system (2017)

A dielectric rod antenna was constructed for stimulating biological tissues. The antenna consists of three sections (a conical wave launcher, a cylindrical waveguide, and a conical emitting section). The simulation of the antenna in free space was confirmed with measurements of the return loss (S11) and the transient electric field. To reach the electric field threshold for tissue stimulation, a high voltage pulsed power system was designed and constructed to drive the antenna. Central to the pulsed power system is a transformer and an oil peaking switch. The transformer is an ultrafast, dual resonance pulse transformer with a linearly integrated primary (LIP) stage. It is capable of generating pulses with rise time <;50 ns. The load for the transformer was an oil-filled transmission line that was connected to the antenna. An oil peaking switch was used to switch the line to produce high voltage picosecond transients. The electric field was measured in the near field at a distance of 4 cm. A 500 ps pulse with an amplitude of 600 V/cm was recorded for a 25 kV input from the pulse transformer. These results demonstrate the feasibility of the system and so future work will be focused on increasing the voltage and the electric field in order to stimulate biological tissues.
ChemInform Abstract: STUDIES ON AS‐TRIAZINE DERIVATIVES. V. SYNTHESIS AND HYDRATION OF ALKYNYL‐1,2,4‐TRIAZINES (1985)

Abstract Die Palladium‐katalysierte Kupplung der S‐Iod‐as‐triazine (II) bzw. des B‐Iod‐as‐triazins (VIII) mit monosubstituierten Acetylenen (III) ergibt die entsprechenden Alkinyl‐triazine (IV) und (IX).
Production of Endothelin-1 and Big-Endothelin-1 by Tumor Cells with Epithelial-Like Morphology (1989)

Immunoreactive endothelin (ET) and big-endothelin (big-ET) in conditioned media of endothelial and of non-endothelial cells were studied using sandwich-type enzyme immunoassays. Immunoreactivities of both ETs were detected in the media of all four endothelial cells tested. Among non-endothelial cells, tumor cell lines with epithelial-like morphology also produced immunoreactive ET and/or big-ET, although the total amount of ETs was one or two orders of magnitude less than that produced by PAE (porcine aortic endothelial cells). Immunoreactive ETs produced by HepG-2 (human hepatocellular carcinoma) and some other cells were characterized by gel-filtration HPLC and reverse-phase HPLC. These studies revealed the production of ET-1 and human big-ET-1 by these cells, although the immunoreactive ETs produced by the tumor cells were more heterogeneous than those produced by endothelial cells. The regulatory effects of thrombin and transforming growth factor-beta (TGF-beta) on the production of ETs were investigated. TGF-beta markedly stimulated the production of both ETs in HepG-2 and slightly decreased the big-ET level in A549 (human lung carcinoma). HPLC analysis showed that the major immunoreactive ETs induced by TGF-beta in HepG-2 were identical to ET-1 and human big-ET-1. These results demonstrated that production of ET-1 and big-ET-1 was not restricted to endothelial cells and was induced by TGF-beta in HepG-2 at the same levels as those produced by PAE.
Billion-scale Network Embedding with Iterative Random Projection (2018)

Network embedding, which learns low-dimensional vector representation for nodes in the network, has attracted considerable research attention recently. However, the existing methods are incapable of handling billion-scale networks, because they are computationally expensive and, at the same time, difficult to be accelerated by distributed computing schemes. To address these problems, we propose RandNE (Iterative Random Projection Network Embedding), a novel and simple billion-scale network embedding method. Specifically, we propose a Gaussian random projection approach to map the network into a low-dimensional embedding space while preserving the high-order proximities between nodes. To reduce the time complexity, we design an iterative projection procedure to avoid the explicit calculation of the high-order proximities. Theoretical analysis shows that our method is extremely efficient, and friendly to distributed computing schemes without any communication cost in the calculation. We also design a dynamic updating procedure which can efficiently incorporate the dynamic changes of the networks without error aggregation. Extensive experimental results demonstrate the efficiency and efficacy of RandNE over state-of-the-art methods in several tasks including network reconstruction, link prediction and node classification on multiple datasets with different scales, ranging from thousands to billions of nodes and edges.
Tricuspid annuloplasty. Five and one-half years' experience with 78 patients. (1974)

From January, 1968, through June, 1973, 78 tricuspid annuloplasties and 90 tricuspid valve replacements were performed in association with mitral or mitral-aortic valve procedures. Tricuspid insufficiency was not recognized preoperatively (either clinically or by cardiac catheterization) in 35 per cent of these patients, a fact which emphasizes the importance of routine digital palpation of the tricuspid valve. The severity of tricuspid disease was roughly comparable in the two groups. The hospital mortality rate was 14 per cent in the annuloplasty group and 34 per cent in the replacement group. Late deaths occurred in 17 and 19 per cent of the two groups, respectively. Sixty-nine per cent of the patients having tricuspid annuloplasty are currently alive, as compared to 45 per cent of the patients having tricuspid valve replacement. Tricuspid insufficiency recurred in 5 patients after annuloplasty and resulted from an inadequate mitral valve procedure or left ventricular failure. The present study suggests that tricuspid annuloplasty is a rapid and reliable means of correcting tricuspid insufficiency and is superior to tricuspid valve replacement.
The Potential Role of Natural Killer Cells in the Treatment of Malignant Disease (2008)

Modern transfusion medicine is sophisticated hemotherapy. Cellular and humoral blood components can be relevant in virtually every disease, either as a primary determinant in pathophysiology or as a victim of collateral damage, e.g. during treatment with cytostatic drugs, or as crucial substrates in replacement and hemostasis-navigated hemotherapy. With its interdisciplinary approach modern hemotherapy is a paragon of translational research bridging the bench-to-bedside gap in biomedicine. The state-of-the-art contributions collected here aim to stimulate lively discussions - not only among blood center professionals but also with blood and vascular biologists, hematologists, immunologists, anesthesiologists, intensive care specialists, surgeons, cardiologists, nephrologists, rheumatologists, and pulmonary and infectious disease specialists.
Abstract 14056: Prognostic Value of SmartMIBG-HF Risk Score in Patients With Preserved Left Ventricular Ejection Fraction Admitted for Acute Decompensated Heart Failure (2016)

Background: Cardiac iodine-123 metaiodobenzylguanidine (MIBG) imaging has been shown to provide prognostic information in patients with heart failure (HF) with preserved ejection fraction (HFpEF). On the other hand, smartMIBG-HF software, which has been recently generated from the database of chronic HF patients, is a useful computer application that evaluates the risk of 5-year cardiac mortality using baseline 5 parameters including NYHA class, age, gender, left ventricular ejection fraction (LVEF), and the late heart-to-mediastinum ratio obtained from cardiac MIBG imaging. Purpose: We sought to elucidate whether the risk levels calculated by smartMIBG-HF software have predictive value even in HFpEF patients admitted for acute decompensated heart failure (ADHF). Methods: We studied 104 consecutive patients admitted for ADHF and discharged with survival whose LVEF was ≧40% (age: 77±12 years, male: 50%, NYHA class at discharge: 2.1±0.8). Cardiac MIBG imaging and echocardiography were performed just before discharge, and we obtained smartMIBG-HF risk score by the software. The endpoints were unplanned hospitalization for worsening heart failure (WHF) and pump failure death (PFD). Results: During a follow-up period of 2.0±0.8 years, 37 patients had WHF and 8 patients had PFD. At multivariate Cox analysis, out of the variables including clinical, hemodynamic, biochemical, MIBG, echocardiographic parameters and smartMIBG-HF risk score, smartMIBG-HF risk score was significantly independently associated with WHF (p 19% and >23% had a significantly higher risk of WHF (p=0.0001) and PFD (p Conclusions: SmartMIBG-HF risk score would be useful for the risk stratification even in HFpEF patients admitted for ADHF.
A macrostructure of petroleum asphalt (1990)

Asphalt is largely composed of (a) asphaltenes, the dispersed phase or micellar phase, (b) resins, the peptizing agent, and (c) gas oil (composed of saturates and aromatics), the dispersing medium or the intermicellar medium. The minor constituents are organometallics (such as porphyrins), metals and polar moleculars (such as surfactants). Chemically, an asphaltene is a very complex macromolecule belonging to the class of multipolymers, and only a statistically averaged chemical structure is known. Although the asphaltene contents vary in each asphalt, there is no asphalt which does not contain asphaltenes. This paper presents a study of the macrostructure of petroleum asphalt and examines the role of asphaltenes in asphalt systems.