gebhart/patrepeval huggingface dataset:
The Translational Repression Mediated by the Platelet-derived Growth Factor 2/c-sis mRNA Leader Is Relieved during Megakaryocytic Differentiation (1995)

Expression of the platelet-derived growth factor 2/c-sis gene is highly restricted and controlled at multiple levels. Its structured mRNA leader, which is unusually long (1022 nucleotides), serves as a potent translational inhibitor. One of the sites of PDGF2 synthesis is megakaryocytes, implying that PDGF2 translation efficiency is modulated during megakaryocytic differentiation. To study the role of the mRNA leader as a translational cis-modulator, the hybrid T7/vaccinia cytoplasmic expression system was used to disconnect between determinants controlling transcription, alternative splicing, and mRNA stability from those controlling translation. Chimeric transcripts in which the human PDGF2/c-sis mRNA leader positioned in frame upstream of a reporter gene were used to determine whether the mRNA leader can confer variable translational efficiencies during differentiation. It is demonstrated that there is a time window during megakaryocytic differentiation of K562 cells in which the strong translational inhibition by PDGF2/c-sis mRNA leader is relieved. The time course of the translational repression relief is similar to that of PDGF2/c-sis transcriptional induction during the differentiation process. A 179-nucleotides CG-rich fragment immediately upstream of the initiator AUG codon is necessary for coffering stringent modulation of the translational efficiency. In NIH3T3 overexpressing translation initiation factor eIF4E, the inhibitory effect of the mRNA leader of c-sis is not relieved, suggesting that the changes in the translational machinery during megakaryocytic differentiation are beyond eIF4E activity. The possible involvement of a 5'-end-independent translational mechanism is discussed.
Study on the Crystallinity of Polyaniline (1988)

Abstract WAXD, SEM, DSC and TGA were used to investigate the crystallinity of polyaniline (PAn). The results show that the crystallization behaviors of undoped PAn depend on its polymerization conditions. The crystallinity of undoped PAn decreases with the increasing acidity from 0.001 to 7N in polymerization solution. Doped PAn crystallizes more easily than undoped one and the crystallinity increases with increasing doping level. Appropriate heat treatment can enhance the crystallization ability of PAn.
Pulse Treatments with the Silver Thiosulfate Complex Extend the Vase Life of Cut Carnations1 (1980)

Abstract Immersing stems of carnation flowers ( Dianthus caryophyllus L. cv. White Sim) in solutions containing a silver thiosulfate complex prepared by combining silver nitrate with sodium thiosulfate (molar ratio 1:4) doubled their vase life (from 5 to more than 10 days). The effect could be achieved by treating stems with solutions containing as little as 1.0 mM Ag with a pulse as short as 10 minutes. Silver uptake estimations indicated that a minimum of 0.5 μ mol Ag was required per stem for maximum vase life and that more than 5 μ mol Ag per stem was toxic.
Novel 2-Methyl-1-oxacephalosporins 1. Synthesis of 2-Methyl-3-nor-1-oxacephem Nucleus (1990)

The Zo-and 20-methyl-1-oxacephems were synthesized stereoselectively starting from (3R.4S)-oxazolinoazetidinone by reaction with chiral alcohols followed by intramolecular carbene insertion of a-diazo-6-keto intermediates.1-Oxacephem compounds have received considerable attention since antibacterial activity was~found to be enhanced by the nuclear exchange of the sulfur atom of cephems to 0 ~y ~e n .l -5 We assumed that an introduction of a-or @-methyl substituent on C-2 to the 1-oxacephem ring might confer ring constraint and hence might influence the antibacterial activity including 6-lactamase stability.Herein we report the stereoselective syntheses of novel 2a-methyl-(la and a) and 20methyl-3-nor-1-oxacephems (s and &)6 having a 7u-acylamino group.A chiral building block, (3~.4~)-oxazolinoazetidinone7~10 2 was reacted with neat chiral alcohol (a or B; 300 mglml) in the presence of CF3S03H at room temperature for 1.5 h to give crystalline u-4-alkoxyazetidinone fi (49%; mp 133-135°C) or (53%; mp 104-105'C) in a stereoselective manner,ll respectively.In these cases the yield of 5 was not improved either with solvent (CHC13,
Investigation of Cycle-to-Cycle Variability in HfO2-Based OxRAM (2016)

This letter studies the intrinsic variability in oxide-based resistive RAM technology, highlighting the presence of a short range (≈40) correlation of resistances among cycles (for both low resistance state and high resistance state). Experimental results demonstrate the existence of a resistance correlation, and an analytical model is proposed in order to explain the findings. The presence of the correlation seems to indicate that the conductive filament, which is believed to be the basis of resistive RAM behavior, keeps for a limited number of cycling operations a memory of its morphology. The extension of this correlation depends on the programming conditions.
Synthesis of Heteroarylpiperazines and Heteroarylbipiperidines with a Restricted Side Chain and Their Affinities for 5‐HT1A Receptor. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
[In vitro regulation of the secretion of thymulin (STF) by human thymic epithelial cells]. (1983)

The presence of thymulin (formerly called Facteur Thymique Sérique, FTS) in cultured human thymic epithelial cells was studied using a monoclonal anti-thymulin antibody in an immunofluorescence technique. The percentage of thymulin-containing cells increases gradually as a function of time, from 10% at day 4 to 90% at day 14. Furthermore, this increase can be prevented by the addition of thymulin in the culture medium. These data suggest a feedback control of thymulin secretion by thymic epithelial cells.
Factor VIIa binding to endothelial cell protein C receptor: Differences between mouse and human systems (2012)

Recent in vitro studies have shown that the zymogen and activated form of factor (F)VII bind to endothelial cell protein C receptor (EPCR). At present, there is no evidence that FVIIa binds to EPCR on vascular endothelium in vivo in the presence of circulating protein C, a primary ligand for EPCR. The present study was carried out to investigate the interaction of murine and human ligands with murine EPCR both in vivo and in vitro . Measurement of endogenous plasma levels of FVII in wild-type, EPCR-deficient and EPCR-over expressing mice showed slightly lower levels of FVII in EPCR-over expressing mice. However, infusion of high concentrations of competing ligands, either human APCi or FVIIai, to EPCR-over expressing mice failed to increase plasma levels of mouse FVII whereas they increased the plasma levels of protein C by two- to three-fold. Examining the association of exogenously administered mouse FVIIa or human FVIIa by immunohistochemistry revealed that human, but not murine FVIIa, binds to the murine endothelium in an EPCR-dependent manner. In vitro binding studies performed using surface plasmon resonance and endothelial cells revealed that murine FVIIa binds murine EPCR negligibly. Human FVIIa binding to EPCR, particularly to mouse EPCR, is markedly enhanced by availability of Mg2+ ions. In summary, our data show that murine FVIIa binds poorly to murine EPCR, whereas human FVIIa binds efficiently to both murine and human EPCR. Our data suggest that one should consider the use of human FVIIa in mouse models to investigate the significance of FVIIa and EPCR interaction.
Paraxial Diode Shots on RITS-6. (2020)

Abstract not provided.
Auto-vectorization of interleaved data for SIMD (2006)

Most implementations of the Single Instruction Multiple Data (SIMD) model available today require that data elements be packed in vector registers. Operations on disjoint vector elements are not supported directly and require explicit data reorganization manipulations. Computations on non-contiguous and especially interleaved data appear in important applications, which can greatly benefit from SIMD instructions once the data is reorganized properly. Vectorizing such computations efficiently is therefore an ambitious challenge for both programmers and vectorizing compilers. We demonstrate an automatic compilation scheme that supports effective vectorization in the presence of interleaved data with constant strides that are powers of 2, facilitating data reorganization. We demonstrate how our vectorization scheme applies to dominant SIMD architectures, and present experimental results on a wide range of key kernels, showing speedups in execution time up to 3.7 for interleaving levels (stride) as high as 8.
Error-Correcting Codes for Semiconductor Memory Applications: A State-of-the-Art Review (1984)

This paper presents a state-of-the-art review of error-correcting codes for computer semiconductor memory applications. The construction of four classes of error-correcting codes appropriate for semiconductor memory designs is described, and for each class of codes the number of check bits required for commonly used data lengths is provided. The implementation aspects of error correction and error detection are also discussed, and certain algorithms useful in extending the error-correcting capability for the correction of soft errors such as α-particle-induced errors are examined in some detail.
Visualization and Measurement of the Burning Surface of Wire-Embedded Energetic Materials, Part 1: JA2 and Pentolite (2014)

Abstract : To increase the burning rates of minimum-smoke propellant formulations that are less sensitive than current standards, the Army is investigating gains that are achievable by embedding propellant with thermally conductive wires. The mechanisms that lead to increased burning rates in wired propellant are not fully understood; therefore, grain design optimization is a significant technical challenge. As part of an effort to gain insight into the mechanisms underlying the phenomenon, and thereby accelerate development of the technology, an experimental technique was developed that enables the burning surface of a wire-embedded strand to be visualized throughout the course of a burn rate measurement. Revealing details of the process that are hidden to standard burn rate measurement techniques, the U.S. Army Research Laboratory is developing a state-of-the-art computational fluid dynamics model for simulating the performance of rocket motors with wire-embedded propellant grains.
Evaluation of preoperative serum concentrations of ionized calcium and parathyroid hormone as predictors of hypocalcemia following parathyroidectomy in dogs with primary hyperparathyroidism: 17 cases (2001–2009) (2012)

Preoperative iCa and PTH concentrations were not predictive of postoperative hypocalcemia in dogs undergoing parathyroidectomy for primary hyperparathyroidism. Future studies to evaluate whether calcium supplementation should be provided on an individual basis with perhaps more emphasis on clinical signs than iCa concentrations after surgery may be warranted.
The human milk microbiome: a potential influence on mammary health and bacterial colonization of the infant gut (2010)

Our study investigated the microbiome of healthy human milk collected aseptically from 16 women over a 5‐wk period. Bar‐coded 454 pyrosequencing of 16S rRNA genes produced an average of 4,000 reads per sample, with Streptococcus , Staphylococcus , and Corynebacterium identified as the dominant phylotypes at the genus level when evaluated using the Ribosomal Database Project classifier. The ACE richness metric estimated from 180 to 1,700 distinct phylotypes (97% similarity) in each sample. The community composition of milk collected from each woman was relatively consistent over time; nonetheless, although profiles from each woman tended to cluster together, random shifts occurred at some time points causing drastic changes in microbial community composition. Data reveal that complexity of the milk bacterial communities is comparable to that found on skin or in the mouth, but less complex than that in the gut. In summary, human milk harbors a wide variety of bacteria that appear to change in composition at times perhaps due to environmental characteristics in the mammary gland related to diet, milk composition, or immune factors. These bacterial communities may play pivotal roles in mammary health and colonization of the infant gut. Supported by NIH‐NRRI grants P20 RR15587 and P20 RR16448, and the United Dairymen of Idaho. Grant Funding Source : NIH‐NRRI grants P20 RR15587 and P20 RR16448, andthe United Dairymen of Idaho.
NewC2-Symmetrical 1,2-Diphosphanes for the Efficient Rhodium-Catalyzed Asymmetric Hydroboration of Styrene Derivatives (2001)

A double [2,3] sigmatropic rearrangement enables the fast synthesis of novel C2-symmetrical 1,2-diphosphanes in good yields. These phosphanes (for example, 1; c-Hex=cyclohexyl) are highly efficient ligands for the rhodium-catalyzed asymmetric hydroboration of a wide variety of styrenes (see scheme). cod=1,5-cyclooctadiene; DME=1,2-dimethoxyethane.
A phase II randomized trial of nivolumab with stereotactic body radiotherapy (SBRT) versus nivolumab alone in metastatic (M1) head and neck squamous cell carcinoma (HNSCC). (2018)

6009 Background: A minority of patients with metastatic HNSCC respond to the anti-programmed death (PD-1) monoclonal antibody, Nivolumab (Nivo). We sought to determine whether targeted radiation to a single lesion combined with Nivo would enhance tumor regression in non-irradiated lesions (abscopal response) and improve outcomes. Methods: Patients with M1 HNSCC (including nasopharynx) with at least two RECIST 1.1 measurable lesions were randomized with stratification for viral status (EBV/HPV pos vs. neg) 1:1 to either Nivo alone q 2 weeks or Nivo with SBRT to a single lesion (9 Gy x 3) between the 1st and 2nd doses of Nivo. The primary end-point was objective response rate (ORR) in non-irradiated lesions using RECIST 1.1. Secondary analyses included overall survival (OS), progression free-survival (PFS), and duration-of-response (DOR). We hypothesized that SBRT added to Nivo would increase ORR from 15% to 45%. Enrolling 53 patients thus provides a one-sided alpha of 0.10 and a power of 0.80. Results: 53 patients were randomized, 26 to Nivo alone and 27 to Nivo+SBRT; the lung was the most common irradiated site (59%). There were no significant differences between arms in terms of age (p = 0.12), viral status (pos vs neg; p = 0.786), primary site (oropharynx vs. nasopharynx vs other; p = 1.0), or median lines of prior chemotherapy (1; p = 0.73). ORR in the Nivo alone arm was 26.9% (95% CI: 13.7, 46.1%) vs 22.2% (95% CI: 10.6%, 40.8%) in the Nivo+SBRT arm (p = 0.94). Median DOR with Nivo alone was not reached (NR) vs 9.3 months (95% CI: 5.52, NR) with Nivo+SBRT (p = 0.21). Median follow-up amongst surviving patients was 12.8 mos; OS at 1 year was 64% (95% CI: 47%, 88%) in the Nivo alone arm vs 53% (95% CI: 36%, 79%) in the Nivo+SBRT arm (p = 0.79); median PFS was 1.9 mos (95% CI: 1.78, NR) with Nivo vs 2.4 mos (95% CI: 1.0, 11.4) with Nivo+SBRT (p = 0.8). Treatment-related ≥ Grade 3 toxicities in the Nivo alone vs Nivo+SBRT arms occurred in 15% vs. 11% of patients (p = 0.96). Conclusions: While safe, the addition of SBRT to Nivo in M1 HNSCC failed to improve ORR, PFS, or OS. This is the first randomized evaluation of the abscopal response in any tumor histology. Biomarker analyses are near completion. Clinical trial information: 02684253.
Bonded Concrete Overlays (1970)

Laboratory tests to evaluate the bond between freshly overlaid concrete on an existing concrete surface were studied. Cement grout and epoxy were used separately as bonding agents on two parallel series of tests with preparation of existing surface as a variable. Static and repeated loadings were applied on freshly overlaid precracked concrete beams. The contribution of the bonded concrete overlay to the flexural rigidity of the beam at various stages of loading were determined. It was concluded that concrete overlays can be made to bond to existing concrete surfaces using cement grout or epoxy as bonding agents, and that repeated loadings within the working range will not cause bond failure between the two concretes. Thin bonded concrete overlays were found to increase considerably the flexural rigidity and the ultimate moment capacity of the existing concrete section.
Photoactive Area Dependent Electrochemical Characteristics of Photoelectrochemical Cells (2015)

We demonstrate that the experimentally obtained photocurrent density (mA/cm 2 ) of a WO 3 based photoelectrochemical cell decreases as a function of increasing photoactive area. This trend is predominantly caused by a non-linear decrease in resistance of the interface between the conducting FTO electrode and the photoactive material (WO 3 ), as determined by electrochemical impedance spectroscopy. In agreement with this observation is that the relatively high interfacial resistance of large area electrodes can be reduced by introduction of conductive layers, as is evident from improved photocurrents obtained for relatively large, graphitized C 70 modified WO 3 photo-electrodes.
KIAA1524/CIP2A promotes cancer growth by coordinating the activities of MTORC1 and MYC (2014)

KIAA1524/CIP2A/cancerous inhibitor of protein phosphatase 2A is a cancer-promoting protein that stabilizes the MYC proto-oncogene protein by inhibiting its dephosphorylation. Our recent report demonstrates that KIAA1524/CIP2A supports cancer cell growth also at the level of the mechanistic target of rapamycin complex 1 (MTORC1), a key signaling module that drives cell growth by stimulating protein synthesis and inhibiting autophagy. KIAA1524/CIP2A suppresses MTORC1-associated protein phosphatase 2A (PP2A) activity in an allosteric manner thereby stabilizing the phosphorylation of MTORC1 substrates and keeping the cell in an anabolic mode. In the absence of growth stimulating signals or nutrients, reduced MTORC1 activity triggers SQSTM1/p62-dependent autophagic degradation of KIAA1524/CIP2A enhancing the PP2A-mediated dephosphorylation of MTORC1 substrates and MYC. Thus, KIAA1524/CIP2A emerges as an oncoprotein that can coordinate the growth-promoting activities of MTORC1 and MYC in response to environmental and intrinsic cues.
Biosensors: Controlling Lipid Membrane Architecture for Tunable Nanoplasmonic Biosensing (Small 23/2014) (2014)

A biosensing platform is presented by N.-J. Cho and co-workers that utilizes plasmonic nanodisk sensors for detecting lipids and proteins. The image shows circular gold nanodisks deposited on a glass substrate, as directly observed by atomic force microscopy. On page 4828, the nanodisks appear as dark yellow spots and the glass substrate underneath is blue. The platform is suitable for the fabrication of different types of lipid membrane architecture, enabling tunable measurement responses. Platforms of this kind have strong potential for lab-on-a-chip and diagnostic applications.
PSEUDOFILAMENTOUS GREEN ALGAE FORM INDEPENDENT CHLOROPHYTE AND STREPTOPHYTE LINEAGES (2000)

The pseudofilamentous condition in green algae has been characterized as the formation of a linear array of autospores. Although it is likely that this characterization will be found to be an over‐simplification, it serves as a logical starting point for a study of diversity among pseudofilamentous taxa. Therefore, given that molecular phylogenetic analyses have revealed that coccoid, autospore‐formers are found in a number of independent green algal lineages, it is reasonable to expect that pseudofilamentous taxa are likely to be found in a number of distinct lineages. In order to test this hypothesis, data from the nuclear‐encoded 18S r RNA gene were collected from several pseudofilamentous, green algal genera ( Geminella , Gloeotila , Hazenia , Interfilum , Microspora , and Sphaeroplea ) and incorporated into an 18S rRNA database of chlorobiont taxa. Results from phylogenetic analyses of these data support (1) an alliance of Interfilum , two Geminella isolates, and Klebsormidium within the streptophyte lineage, (2) an alliance of two Geminella isolates and Microspora as a sister group to the ulvophycean/chlorophycean/trebouxiophycean clade or as a sister group to trebouxiophycean taxa, (3) an alliance of Hazenia with ulotrichalean taxa, (4) of Gloeotila with trebouxiophycean taxa and (5) an alliance of Sphaeroplea with chlorophycean taxa. These data confirm that the filamentous condition has evolved in a number of independent lineages. Moreover, these data further illustrate that the extent of molecular variability within the green algae is far from fully appreciated.
Adaptive fuzzy throttle control for an all-terrain vehicle (2001)

This paper describes an adaptive fuzzy throttle control for an all-terrain vehicle (ATV) powered by internal combustion engine. The design objective is to provide smooth throttle movement and zero steady state speed error, and to maintain a selected vehicle speed over varying road slopes for a 2–30 mile/h speed range. Unlike modern production vehicles which have microprocessor-based engine management systems, the ATV's engine is mechanically controlled via a carburettor. A complete mathematical model of the engine is not available, making it very difficult to apply conventional control techniques. Using experience and data collected from extensive experiments conducted on the ATV throttle mechanism, an adaptive fuzzy throttle control algorithm is designed. A candidate Lyapunov function is employed in the adaptive law synthesis to ensure convergence. Experimental results are presented showing the effectiveness of the control algorithm at speeds below 2.74 mile/h (1.2m/s).
Automatic analysis of static charge sensitive bed (SCSB) recordings in the evaluation of sleep-related apneas (2009)

An automatic analysis of Static Charge Sensitive Bed (SCSB) recordings was evaluated in the detecting periodic apneas during sleep. The results of over-night SCSB recordings, on body movements and respiratory movements, were compared with the visually evaluated polygraphic recordings during daytime sleep. Twenty-one patients with obstructive sleep apnea syndrome and 18 controls were studied. The periodic breathing pattern seen in all daytime recordings, was also seen in all output graphs of the over-night SCSB analyses. The automatic analyses revealed periodic breathing in 2 control subjects. The amount was, however, small (less than 4% of the recording time) compared with the high amount observed in the patients with obstructive sleep apneas (mean 42.9% of the recording time). The high sensitivity, easy use, and low cost of the automatic SCSB method make it suitable for the quantification of the periodic breathing during night and for the screening of sleep apneas.