gebhart/patrepeval huggingface dataset:
Early virological response predicts outcome during extended lamivudine retreatment in patients with chronic hepatitis B who relapsed after initial HBeAg responses (2006)

EVR is a major predictor in determining a favorable response to lamivudine retreatment. Our observations suggest that lamivudine retreatment will provide more therapeutic gains in those patients with a prior HBeAg seroconversion than in those with HBeAg loss alone.
Ordered and quantum treemaps (2002)

Treemaps, a space-filling method for visualizing large hierarchical data sets, are receiving increasing attention. Several algorithms have been previously proposed to create more useful displays by controlling the aspect ratios of the rectangles that make up a treemap. While these algorithms do improve visibility of small items in a single layout, they introduce instability over time in the display of dynamically changing data, fail to preserve order of the underlying data, and create layouts that are difficult to visually search. In addition, continuous treemap algorithms are not suitable for displaying fixed-sized objects within them, such as images.This paper introduces a new "strip" treemap algorithm which addresses these shortcomings, and analyzes other "pivot" algorithms we recently developed showing the trade-offs between them. These ordered treemap algorithms ensure that items near each other in the given order will be near each other in the treemap layout. Using experimental evidence from Monte Carlo trials and from actual stock market data, we show that, compared to other layout algorithms, ordered treemaps are more stable, while maintaining relatively favorable aspect ratios of the constituent rectangles. A user study with 20 participants clarifies the human performance benefits of the new algorithms. Finally, we present quantum treemap algorithms, which modify the layout of the continuous treemap algorithms to generate rectangles that are integral multiples of an input object size. The quantum treemap algorithm has been applied to PhotoMesa, an application that supports browsing of large numbers of images.
Temperature dependence of emitter-base reverse stress degradation and its mechanism analyzed by MOS structures (2003)

Different degradation modes were observed under high and low reverse stress current conditions. The temperature dependence of the gradation was studied, and it was found that the degradation is greatest around 50 degrees C. The mechanisms of the degradation and its recovery were also investigated, using MOS structures and simulation. MOSFET evaluation indicated that electron trapping and interface state generation occur during the stress. Simulation confirmed that the degradation is caused mainly by the interface states generated in the oxide near the emitter-base junction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Survey of remote terminal emulators (1977)

This report describes twelve Remote Terminal Emulators (RTE's).The key terminology associated with remote terminal emulation is defined and possible application areas are discussed.Technical implementation details and operational considerations are addressed for each RTE.Summary tables are provided to indicate current RTE capabilities and capacities, as claimed by the RTE developers .
Motionally induction voltage techniques: An application to the Ria de Aveiro Lagoon (Portugal) (2002)

Techniques based on motionally induced electric field, which is induced by the water flow across earth’s magnetic field, has recently been demonstrated to provide reliable information when applied to the flow monitoring in large oceanic channels. In the PROTEU project we’ll try to apply this technique to determine in continuous the water inflow into Ria de Aveiro from the feeding Vouga river and the water exchange between the Ria de Aveiro and the inner shelf. For that a cable crossing the strait of the lagoon at Barra is being setup. At once, two pairs of electrodes and a magnetometer were installed inland, near the coast, with continuos measures of electromagnetic fields. A summary of the project principles and examples of the first records of the electromagnetic field made inland are presented in this paper.
Negative Refractive Index at Optical Wavelengths (2007)

Recent progress in terahertz biosensors based on artificial electromagnetic subwavelength structure,
Differential Responsiveness of Innate-like IL-17– and IFN-γ–Producing γδ T Cells to Homeostatic Cytokines (2015)

γδ T cells respond to molecules upregulated following infection or cellular stress using both TCR and non-TCR molecules. The importance of innate signals versus TCR ligation varies greatly. Both innate-like IL-17-producing γδ T (γδT-17) and IFN-γ-producing γδ T (γδT-IFNγ) subsets tune the sensitivity of their TCR following thymic development, allowing robust responses to inflammatory cytokines in the periphery. The remaining conventional γδ T cells retain high TCR responsiveness. We determined homeostatic mechanisms that govern these various subsets in the peripheral lymphoid tissues. We found that, although innate-like γδT-17 and γδT-IFNγ cells share elements of thymic development, they diverge when it comes to homeostasis. Both exhibit acute sensitivity to cytokines compared with conventional γδ T cells, but they do not monopolize the same cytokine. γδT-17 cells rely exclusively on IL-7 for turnover and survival, aligning them with NKT17 cells; IL-7 ligation triggers proliferation, as well as promotes survival, upregulating Bcl-2 and Bcl-xL. γδT-IFNγ cells instead depend heavily on IL-15. They display traits analogous to memory CD8(+) T cells and upregulate Bcl-xL and Mcl-1 upon cytokine stimulation. The conventional γδ T cells display low sensitivity to cytokine-alone stimulation and favor IL-7 for their turnover, characteristics reminiscent of naive αβ T cells, suggesting that they may also require tonic TCR signaling for population maintenance. These survival constraints suggest that γδ T cell subsets do not directly compete with each other for cytokines, but instead fall into resource niches with other functionally similar lymphocytes.
Protein kinase C regulates transcription of the human guanylate cyclase C gene (2001)

Guanylate cyclase C is the receptor for the bacterial heat-stable enterotoxins and guanylin family of peptides, and mediates its action by elevating intracellular cGMP levels. Potentiation of ligand-stimulated activity of guanylate cyclase C in human colonic T84 cells is observed following activation of protein kinase C as a result of direct phosphorylation of guanylate cyclase C. Here, we show that prolonged exposure of cells to phorbol esters results in a decrease in guanylate cyclase C content in 4beta-phorbol 12-myristate 13-acetate-treated cells, as a consequence of a decrease in guanylate cyclase C mRNA levels. The reduction in guanylate cyclase C mRNA was inhibited when cells were treated with 4beta-phorbol 12-myristate 13-acetate (PMA) in the presence of staurosporine, indicating that a primary phosphorylation event by protein kinase C triggered the reduction in RNA levels. The reduction in guanylate cyclase C mRNA levels was not due to alterations in the half-life of guanylate cyclase C mRNA, but regulation occurred at the level of transcription of guanylate cyclase C mRNA. Expression in T84 cells of a guanylate cyclase C promoter-luciferase reporter plasmid, containing 1973 bp of promoter sequence of the guanylate cyclase C gene, indicated that luciferase activity was reduced markedly on PMA treatment of cells, and the protein kinase C-responsive element was present in a 129-bp region of the promoter, containing a HNF4 binding element. Electrophoretic mobility shift assays using an oligonucleotide corresponding to the HNF4 binding site, indicated a decrease in binding of the factor to its cognate sequence in nuclear extracts prepared from PMA-treated cells. We therefore show for the first time that regulation of guanylate cyclase C activity can be controlled at the transcriptional level by cross-talk with signaling pathways that modulate protein kinase C activity. We also suggest a novel regulation of the HNF4 transcription factor by protein kinase C.
Cardiometabolic conflux at the carotid body (2023)

Background: Diabetes is the fastest-growing disease in New Zealand, and when combined with high blood pressure (hypertension), so-called sweet pressure (SP) is the leading cause of mortality. However, controlling SP remains challenging clinically. One target that remains unexploited is the sympathetic nervous system (SNA). As the carotid body (CB) has a pivotal role in regulating SNA, blood pressure and blood glucose, we searched for novel signalling pathways linking the CB with metabolism. Using RNA sequencing, we discovered melanocortin type-4 receptor (MC4R) expression was upregulated in the CB of spontaneously hypertensive rats (SHR) versus Wistar rats; these receptors have an essential role in regulating cardiovascular and energy homeostasis. Hypothesis: We hypothesised that blockade of MC4R within the CB would reduce SNA and alleviate SP. Methods: The SHR was used as a hypertensive-diabetic model as it has glucose intolerance. Using a novel in situ preparation, we recorded SNA activity while injecting an MC4R antagonist (HS014) into the CB via the internal carotid artery. Results: The upregulated MC4R expression in the CB of SHR versus Wistar rat was validated using qPCR and immunocytochemistry. Antagonising MC4R within the CB lowered SNA and prevented the SNA hyperactivation triggered by hyperglycaemia (high glucose). No such responses were found in control Wistar rats. Conclusion: MC4R signalling is a novel mechanism within the CB that depresses ongoing SNA and, importantly, the elevated SNA caused by hyperglycaemia; whether this reduces blood glucose awaits testing in vivo. These data provide a potential mechanism for controlling co-comorbidity of hypertension and blood glucose. Funding: HRC, Royal Society Te Apārangi and Sidney Taylor Trust funded this research. This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.
Combined Chemical Looping: New Possibilities for Energy Storage and Conversion (2017)

A novel concept of energy storage and conversion was demonstrated in a laboratory-scale test. The proposed combined chemical looping is able to store and release energy from chemical looping combustion for heat generation and hydrogen production by steam–iron processes integrated in one reactor. The reactor contains two concentric chambers, which are both filled with iron-based material. In a first step, all material is reduced to the metallic form, thus “charging” the reactor. For the second step or “discharging”, steam is fed to the inner chamber and air is fed to the outer chamber. The inner chamber is used for hydrogen production, and the external chamber is used for heat generation. In addition to iron, the external chamber contains a highly pyrophoric Ni-based layer at the air entry point to enable the startup of heat generation at room temperature. This concept of combined chemical looping was successfully tested: heat was generated by metal oxidation in air, and H2 was produced following contact of the reduced sample with H2O, with an average space time yield of 0.2 molH2 kgFe–1 s–1.
Abstract 11126: CT Angiography Based Fractional Flow Reserve Compared to Catheter-based Stress Diastolic Fractional Flow Reserve in Symptomatic Patients With Myocardial Bridges (2019)

Introduction: Myocardial bridging (MB) is a common coronary artery variant. Although traditionally considered benign, MB may be associated with myocardial ischemia as a result of dynamic compressio...
Silicon optomechanical crystal resonator at millikelvin temperatures (2014)

Optical measurements of a nanoscale silicon optomechanical crystal cavity with a mechanical resonance frequency of $3.6$ GHz are performed at subkelvin temperatures. We infer optical-absorption-induced heating and damping of the mechanical resonator from measurements of phonon occupancy and motional sideband asymmetry. At the lowest probe power and lowest fridge temperature (${T}_{\mathrm{f}}=10$ mK), the localized mechanical resonance is found to couple at a rate of ${\ensuremath{\gamma}}_{\mathrm{i}}/2\ensuremath{\pi}=400$ Hz (${Q}_{\mathrm{m}}=9\ifmmode\times\else\texttimes\fi{}{10}^{6}$) to a thermal bath of temperature ${T}_{\mathrm{b}}\ensuremath{\approx}270$ mK. These measurements indicate that silicon optomechanical crystals cooled to millikelvin temperatures should be suitable for a variety of experiments involving coherent coupling between photons and phonons at the single quanta level.
Omnidirectional reflection from a one-dimensional photonic crystal (1998)

We demonstrate that one-dimensional photonic crystal structures (such as multilayer films) can exhibit complete reflection of radiation in a given frequency range for all incident angles and polarizations. We derive a general criterion for this behavior that does not require materials with very large indices. We perform numerical studies that illustrate this effect.
Antitumor and Immunopotentiating Effects of Manda Enzyme (1996)

This study was to evaluate the antitumor and immunopotentiation effects of Manda Enzyme (ME). Oral administration of ME (0.2ml/mouse) to tumor bearing mice significantly prolonged survival rate compared to the control group with the prolongation ratio of 40%. The inhibition ratios for the first and the second experiments were 51.8% and 26.4%, respectively. Only the spleen index was significantly increased in the MEF-treated group, but not in the control group. Gamma globulin level of the MEF-treated group was elevated when mice were injected with sarcoma-180 cells on the left groin. Activities of natural killer (NK) and lymphokineactivated killer (LAK) cells were observed by method. Activities of NK cell against YAC-1 cells were significantly increased in the MEF treated group. And LAK cell activities against P815 cells were also significantly increased in the experimental group. These observations, therefore, suggest that ME may have an anticancer effect and immunopotentiating effect in vivo.
Progress in molecular biology and translational science (2008)

Preface David B. Teplow 1. Adult Stem Cells for Regenerative Therapy Narasimman Gurusamy, Abdulrhman Alsayari, Sheeja Rajasingh and Johnson Rajasingh 2. Hair Follicle-Associated Pluripotent (HAP) Stem Cells Robert M. Hoffman and Yasuyuki Amoh 3. Fluorescent Proteins as Sensors for Cellular Behavior in Mice Robert M. Hoffman 4. Arrestins: Introducing Signaling Bias Into Multifunctional Proteins Vsevolod V. Gurevich, Qiuyan Chen and Eugenia V. Gurevich 5. Analysis of Biased Agonism Frederick J. Ehlert 6. Effects of Estrogens on Central Nervous System Neurotransmission: Implications for Sex Differences in Mental Disorders Kristen N. Krolick, Qi Zhu and Haifei Shi
Crystallization-Induced Interconnected Structure in Semicrystallizable Polyester/Polyether Binary Blends (2006)

The viscosity of binary blends containing one crystallizable component has been analyzed. The elastic moduli of these phase-separated blends exhibit extremely interesting discontinuities as a function of the overall sample composition. These abrupt changes cannot be attributed to the volume fraction of the crystallizable polyester-rich domains but rather to the extremely small amount (∼2% polyester) of unusual needle-shaped crystallites in the polyester-poor regions and interactions between domains and matrix. Therefore, the overall mechanical property of the binary blend must be considered in terms of the volume fraction of the polyester-rich domains interconnected by these unusual polyester-poor regions.
Abstract 4830: Prognostic value of circulating tumor cells with podoplanin expression in locally advanced and metastatic head and neck squamous cell carcinoma (2014)

Abstract Podoplanin (PDPN) is a biomarker for poor prognosis in head and neck squamous cell carcinoma (HNSCC). A prospective study was designed to investigate the prognostic value of circulating tumor cells (CTCs) with PDPN expression (PDPN+-CTCs) in HNSCC patients. Sixty-one healthy donors and fifty-three HNSCC patients with locally advanced and metastatic diseases were enrolled in this study. CTCs were enriched from the peripheral blood by the negative selection method PowerMag that has been validated in our previous study. Enumeration of CTCs was performed by co-immunofluorescence staining using the anti-epithelial cell adhesion molecule (EpCAM) and anti-PDPN antibodies. The CTCs (EpCAM+) and PDPN+-CTCs (EpCAM+PDPN+) counts between the patients and healthy volunteers were statistically different (p &amp;lt; 0.0001). When assessed the progression-free survival (PFS) and overall survival (OS) of the patients, we found that the median PFS for the patient group was 8.6 (95% CI: 4.781-12.419) months and the median OS has not reached 50% after the follow-up duration of 9.1 (5.2-17.1) months. Analysis of the CTCs and PDPN+-CTCs counts revealed that neither of them can be considered as a predictive factor for PFS and OS. Notably, the ratio for the PDPN+-CTCs over total CTCs has progonic value in the assessment of PFS and OS. Based on the ROC curve, the prediction of 6-month death could be revealed at the cutoff value of 20% (AUC: 0.718, sensitivity: 94.7%, specificity: 51.7%, p = 0.011). The patients with PDPN+/EpCAM+-CTCs ratio &amp;gt;20% were associated with poor PFS (hazard ratio (HR): 4.666, 95% CI: 1.373-15.856, p = 0.016) and OS (HR: 12.400, 95% CI: 1.643-93.570, p = 0.015). Kaplan-Meier survival curve further confirmed that the PDPN+/EpCAM+-CTCs ratio had significant impact on PFS (p = 0.006) and OS (p = 0.008). In conclusion, CTCs enumeration clearly differentiates HNSCC patients from healthy individuals, while the PDPN+/EpCAM+-CTC ratio is more important than the absolute CTCs count in determining the degree of malignancy and serves as an independent prognostic factor for PFS and OS. Citation Format: Ching-Ping Tseng, Hung-Chih Lin, Chia-Hsun Hsieh, Hung-Ming Wang, Ju-Chien Cheng. Prognostic value of circulating tumor cells with podoplanin expression in locally advanced and metastatic head and neck squamous cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4830. doi:10.1158/1538-7445.AM2014-4830
Elevated expression of endoglin, a component of the TGF-?-receptor complex, correlates with proliferation of tumor endothelial cells (1999)

Endoglin/CD105 is a membrane protein involved in the TGF-beta receptor signalling pathway. Endoglin expression has been reported to be selective for a few cell types, in particular endothelial cells, although a number of conflicting reports have been published. In this study, we performed a detailed analysis of endoglin expression in human lung tumors and different tumor and endothelial cell lines, employing reverse-transcriptase-polymerase-chain reaction as well as immunoblotting and immunohistochemistry using verified antibodies to endoglin. Our data show a clearly preferential expression of both endoglin mRNA and protein in endothelial cells. In tumors, endoglin expression was strongly elevated in the angiogenic endothelium at the tumor edges. In agreement with this observation, we find a clear correlation between endoglin expression and markers of proliferation, such as cyclin A and Ki-67, suggesting that endoglin expression is linked to cell-cycle regulation. These findings not only resolve some of the discrepancies in the literature, but also provide the basis for further applications making use of its selective localization and expression in the tumor vasculature.
Synthesis and Characterization of Sequence-Controlled Semicrystalline Comb Copolymers: Influence of Primary Structure on Materials Properties (2014)

Sequence-controlled semicrystalline copolymers were prepared by nitroxide-mediated copolymerization of a large excess of octadecylstyrene with small amounts of functional N-substituted maleimides (i.e., N-(n-propyl)maleimide, N-benzylmaleimide, pentafluorophenyl 4-maleimidobenzoate, 4-(N-maleimido)azobenzene, N-(1-pyrenyl)maleimide, and N-(2-(amino-BOC)ethylene)maleimide). These copolymers were prepared in bulk at 110 °C using the commercial alkoxyamine BlocBuilder MA as initiator and control agent. Time-controlled additions protocols were used to place the N-substituted maleimides at precise chain location along the poly(octadecylstyrene) backbones. Size exclusion chromatography and 1H NMR studies indicated that well-defined copolymers with controlled monomer sequences, composition, chain length, and molecular weight distribution were formed in all cases. Although possessing an atactic backbone, these polymers exhibit a semicrystalline behavior. The electron diffraction method indicated that the octadecyl side chains form lamellar phases. Moreover, differential scanning calorimetry studies evidenced a melting temperature in the range 40–45 °C and a crystallization temperature around 30–35 °C. It was observed that melting is influenced by the composition and sequence distribution of the copolymers. Thus, small microstructural variations allow a precise control over order–disorder transitions.
Analysis of systematic errors in lateral shearing interferometry for EUV optical testing (2009)

Lateral shearing interferometry (LSI) provides a simple means for characterizing the aberrations in optical systems at EUV wavelengths. In LSI, the test wavefront is incident on a low-frequency grating which causes the resulting diffracted orders to interfere on the CCD. Due to its simple experimental setup and high photon efficiency, LSI is an attractive alternative to point diffraction interferometry and other methods that require spatially filtering the wavefront through small pinholes which notoriously suffer from low contrast fringes and improper alignment. In order to demonstrate that LSI can be accurate and robust enough to meet industry standards, analytic models are presented to study the effects of unwanted grating and detector tilt on the system aberrations, and a method for identifying and correcting for these errors in alignment is proposed. The models are subsequently verified by numerical simulation. Finally, an analysis is performed of how errors in the identification and correction of grating and detector misalignment propagate to errors in fringe analysis.