gebhart/patrepeval huggingface dataset:
Temperature-Dependent Development and Thermal Sensitivity of Blaptica dubia (Blattodea: Blaberidae) (2016)

Temperature-dependent development of nymphs of the Dubia cockroach, Blaptica dubia Serville, was described using constant-temperature data collected from laboratory experiments at 15, 20, 25, 30, 35, and 40 °C. Simple linear regression models were developed based on the data from each instar. Degree-days required to complete a particular life stage were estimated as 457.5, 668, 1,031, 1,317, 1,515, 1,429, and 2,071 for instars 1-7, respectively. Nymphs developed to adulthood at 20, 25, and 30 °C, but all died before developing into fifth instar at 35 °C and into second instar at 40 °C. Critical thermal maximum (CTMax) and critical thermal minimum (CTMin) of B. dubia were also measured for each instar. CTMax ranged from 44.8 to 49.9 °C for fourth and second instars, respectively. CTMin ranged from approximately -2 °C for seventh instar to - 3.1 °C for second instar. There was no relationship between body mass (instar) and CTMax; however, CTMin was positively correlated with body mass. These results could be used to control the development rate of B. dubia and adjust the optimal rearing temperature for B. dubia in a given situation.
Robust adaptive beamforming using worst-case SINR optimization: a new diagonal loading-type solution for general-rank signal models (2004)

The performance of adaptive beamforming methods may degrade in the presence of even slight mismatches between the actual and presumed array responses to the desired signal. This paper addresses the problem of robust adaptive beamforming in the presence of unknown arbitrary (yet norm-bounded) mismatches of such type as well as interference-plus-noise covariance matrix mismatch. Our approach is developed for the case of an arbitrary dimension of the signal subspace and, therefore, it can be applied to both rank-one and higher-rank signal models. The proposed beamformer is based on the optimization of the worst-case signal-to-interference-plus-noise ratio (SINR). The obtained closed-form solution combines two different types of diagonal loading (DL) applied to the signal and data covariance matrices. An efficient on-line implementation of our beamformer is developed. Simulations validate substantial performance improvements relative to other popular adaptive beamforming techniques.
Energy-recycling Semi-active Method for Vibration Suppression with Piezoelectric Transducers (2003)

*A novel energy-recycling method is studied that enables effective semi-active vibration suppression with piezoelectric transducers embedded or bonded to a structure. In this method, the energy converted from the mechanical energy of a vibrating structure is collected in the capacitor of a piezoelectric transducer as an electric charge, and to suppress vibration, rather than dissipate the energy, the polarity of the charge is changed according to the state of vibration. With this method, no energy is supplied to the total system of the structure and transducers with shunt circuit, which means that the system is stable. A simple electric circuit and a control law for multiple-degree-offreedom systems with multiple piezoelectric transducers are proposed for this method based on energy recycling. Numerical simulation of vibration suppression of a truss structure shows that this method is more effective in suppressing vibration than both a semi-active method without energy-recycling and that based on the use of an optimally tuned passive system. A preliminary experiment with a truss structure also shows that this method can effectively suppress vibration in an actual structure. However, there was some discrepancy in the experimental results compared to the results of the numerical simulation performed assuming ideal linear characteristics of the piezoelectric transducers estimated from a static test. Nomenclature
The N-Of-1 Clinical Trial: The Ultimate Strategy For Individualizing Medicine? (2011)

N-of-1 or single subject clinical trials consider an individual patient as the sole unit of observation in a study investigating the efficacy or side-effect profiles of different interventions. The ultimate goal of an n-of-1 trial is to determine the optimal or best intervention for an individual patient using objective data-driven criteria. Such trials can leverage study design and statistical techniques associated with standard population-based clinical trials, including randomization, washout and crossover periods, as well as placebo controls. Despite their obvious appeal and wide use in educational settings, n-of-1 trials have been used sparingly in medical and general clinical settings. We briefly review the history, motivation and design of n-of-1 trials and emphasize the great utility of modern wireless medical monitoring devices in their execution. We ultimately argue that n-of-1 trials demand serious attention among the health research and clinical care communities given the contemporary focus on individualized medicine.
Suppression Failure of Cortisol Secretion by Dexamethasone May Occur in Glucagon-like Peptide-1 Receptor Agonist-treated Patients with Diabetic Autonomic Neuropathy (2018)

Two diabetic women (case 1, 75 years old; case 2, 49 years old) being treated with glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs) showed no suppression of cortisol secretion on a dexamethasone suppression test (DST). However, its secretion was suppressed after switching from GLP-1 RAs to insulin. We also checked the cortisol secretion by a DST in five consecutive inpatients (case 3-7) being treated with GLP-1 RAs. The coefficients of R-R interval variation at rest and during deep breathing were lower in the two false-positive cases (case 1 and 2) than in the five true-negative cases (case 3-6). GLP-1 RAs can be switched to insulin in order to eliminate the slow absorption effect of dexamethasone by GLP-1 RAs if a DST is planned in diabetic patients receiving GLP-1 RAs.
Message from the program chair (2012)

It is an honor to introduce the technical program for the 39 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> International Symposium on Computer Architecture (ISCA 2012). This symposium is the premier forum for new ideas and results in the area of computer architecture. This year's program includes 47 papers on a broad set of topics, keynotes from Jeff Hawkins (Numenta) and Justin Rattner (Intel), and a set of workshops and tutorials coordinated by Alaa Alameldeen and Benjamin Lee.
Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin. (1993)

Aberrantly phosphorylated tau proteins (i.e., A68 or PHF-tau) and beta-amyloid or A4 (beta A4) peptides are major components of pathologic lesions in Alzheimer disease (AD). Although A68 and beta A4 colocalize in AD neurofibrillary tangles (NFTs) and amyloid-rich senile plaques (SPs), the mechanisms leading to the convergence of A68, beta A4, and other proteins in the same AD lesions are unknown. To probe the biological properties of A68 in vivo, and to assess interactions of A68 with endogenous proteins in the rodent brain, we injected A68, dephosphorylated A68 (DEP-A68), and normal adult human tau protein into the hippocampus and neocortex of rats. In marked contrast to DEP-A68 and tau, A68 resisted rapid proteolysis and induced codeposits of three rodent proteins--i.e., beta A4, ubiquitin, and alpha 1-antichymotrypsin (ACT)--that accumulate in AD NFTs and SPs together with A68. These findings suggest that A68 may interact with beta A4, ubiquitin, and ACT in neuronal perikarya as well as in the extracellular space after release of A68 from degenerating neurons. The model system described here will facilitate efforts to elucidate mechanisms leading to the convergence of A68, beta A4, ubiquitin, and ACT in hallmark lesions of AD.
Oxidative Stress Contributes to Lung Injury and Barrier Dysfunction via Microtubule Destabilization (2012)

Oxidative stress is an important part of host innate immune response to foreign pathogens, such as bacterial LPS, but excessive activation of redox signaling may lead to pathologic endothelial cell (EC) activation and barrier dysfunction. Microtubules (MTs) play an important role in agonist-induced regulation of vascular endothelial permeability, but their impact in modulation of inflammation and EC barrier has not been yet investigated. This study examined the effects of LPS-induced oxidative stress on MT dynamics and the involvement of MTs in the LPS-induced mechanisms of Rho activation, EC permeability, and lung injury. LPS treatment of pulmonary vascular EC induced elevation of reactive oxygen species (ROS) and caused oxidative stress associated with EC hyperpermeability, cytoskeletal remodeling, and formation of paracellular gaps, as well as activation of Rho, p38 stress kinase, and NF-κB signaling, the hallmarks of endothelial barrier dysfunction. LPS also triggered ROS-dependent disassembly of the MT network, leading to activation of MT-dependent signaling. Stabilization of MTs with epothilone B, or inhibition of MT-associated guanine nucleotide exchange factor (GEF)-H1 activity by silencing RNA-mediated knockdown, suppressed LPS-induced EC barrier dysfunction in vitro, and attenuated vascular leak and lung inflammation in vivo. LPS disruptive effects were linked to activation of Rho signaling caused by LPS-induced MT disassembly and release of Rho-specific GEF-H1 from MTs. These studies demonstrate, for the first time, the mechanism of ROS-induced Rho activation via destabilization of MTs and GEF-H1-dependent activation of Rho signaling, leading to pulmonary EC barrier dysfunction and exacerbation of LPS-induced inflammation.
[Rate of DNA synthesis and the size of replication units in cell culture of Drosophila melanogaster]. (1979)

The rate of DNA replication and the size of replication units was examined by means of pulse-labeling with 3H-thymidine and DNA autoradiography in the chromsomes of Drosophila melanogaster synchronized cells culture in vitro. The center-to-center distance between adjacent labeled section of DNA fibers was taken for a size of replication unit, i.e. replicon. DNA synthesis was revealed to start simultaneously in most replicons. The rate of elongation of labeled sections of DNA fibers is about 25 mu per hour (75 kb per hour). Taking into consideration bidirectinal DNA replication the rate of DNA replication per growing point is 12.5 mu per hour (38 kb per hour). The mean size of replicon is about 60 mu (130 kb) in cell culture of Drosophila melanogaster and most of these replicons vary from 20 to 80 mu. Calculation suggests that one replicon may consist of six chromomeres each being known to be formed by a segment of DNA molecular 10 mu long on average.
Asymptotic delay in random wireless networks (2003)

An estimate of the average delay experienced by data bits transported through randomly distributed nodes forming a multi-hop wireless network is presented, as an order of the number of nodes in the network. It is seen that the expected asymptotic delay observed per bit, from a source to a destination node, essentially averages to the order of O (/spl radic/n), for n nodes in the network.
Management guideline for Werner syndrome 2020 1. Dyslipidemia and fatty liver associated with Werner syndrome (2020)

For the purpose of examining the characteristics of dyslipidemia and fatty liver in patients with Werner syndrome in Japan in recent years, we searched all case reports of Japanese Werner syndrome reported on Medical Online and PubMed since 1996, and collected and examined the data and clinical features described in these reports. In addition, as there are few descriptions of treatment methods in these reports from Medical Online and PubMed, we analyzed 12 cases for which detailed data on treatment methods are available at Chiba University. Geriatr Gerontol Int 2021; 21: 133-138.
Direct, Differential Effects of Tamoxifen, 4-Hydroxytamoxifen, and Raloxifene on Cardiac Myocyte Contractility and Calcium Handling (2013)

Tamoxifen (Tam), a selective estrogen receptor modulator, is in wide clinical use for the treatment and prevention of breast cancer. High Tam doses have been used for treatment of gliomas and cancers with multiple drug resistance, but long QT Syndrome is a side effect. Tam is also used experimentally in mice for inducible gene knockout in numerous tissues, including heart; however, the potential direct effects of Tam on cardiac myocyte mechanical function are not known. The goal of this study was to determine the direct, acute effects of Tam, its active metabolite 4-hydroxytamoxifen (4OHT), and related drug raloxifene (Ral) on isolated rat cardiac myocyte mechanical function and calcium handling. Tam decreased contraction amplitude, slowed relaxation, and decreased Ca²⁺ transient amplitude. Effects were primarily observed at 5 and 10 μM Tam, which is relevant for high dose Tam treatment in cancer patients as well as Tam-mediated gene excision in mice. Myocytes treated with 4OHT responded similarly to Tam-treated cells with regard to both contractility and calcium handling, suggesting an estrogen-receptor independent mechanism is responsible for the effects. In contrast, Ral increased contraction and Ca²⁺ transient amplitudes. At 10 μM, all drugs had a time-dependent effect to abolish cellular contraction. In conclusion, Tam, 4OHT, and Ral adversely and differentially alter cardiac myocyte contractility and Ca²⁺ handling. These findings have important implications for understanding the Tam-induced cardiomyopathy in gene excision studies and may be important for understanding effects on cardiac performance in patients undergoing high-dose Tam therapy.
THE HALOGENATION OF ARYLOXYACETIC ACIDS AND THEIR HOMOLOGS (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE HALOGENATION OF ARYLOXYACETIC ACIDS AND THEIR HOMOLOGSL. HASKELBERGCite this: J. Org. Chem. 1947, 12, 3, 426–433Publication Date (Print):May 1, 1947Publication History Published online1 May 2002Published inissue 1 May 1947https://pubs.acs.org/doi/10.1021/jo01167a009https://doi.org/10.1021/jo01167a009research-articleACS PublicationsRequest reuse permissionsArticle Views215Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Direct Thrombin Inhibitors and Factor Xa Inhibitors Can Influence the Diluted Prothrombin Time Used as the Initial Screen for Lupus Anticoagulant (2013)

Here we provide evidence that both the direct thrombin and indirect factor Xa inhibitors influence dPT assay for LA, causing false positivity. This should be considered when interpreting LA results during anticoagulant therapy. However, dPT seems to be a reliable test for LA screening under enoxaparin therapy after neutralization by heparinase.
Characterization of Surface Free Energy of Composite Electrodes for Lithium-Ion Batteries (2018)

One critical step in lithium-ion battery manufacturing process is the electrolyte wetting step, which usually takes up to several days at elevated temperatures, posing a distinctive bottleneck in the manufacturing process especially for large-size cells. The electrode wettability depends on both the surface tension of electrolyte and the surface free energy of electrodes. This work reports a systematic study on the characterization of surface free energy of battery electrodes and the correlation between surface free energy and electrode processing. It shows that, when switching manufacturing from conventional solvent based processing to aqueous processing, the polar component of surface free energy increases 74.1% for NMC532 electrodes and 48.2% for A12 graphite electrodes. The results provide valuable guidance for electrode processing to optimize the electrolyte wetting process, helping lower processing costs and enable higher product quality and throughput.
PROBLEMS AND SUGGESTION ON RADIOISOTOPE TRACING EXPERIMENT (2007)

Problems and suggestions on radioisotope tracing experiment were summarized in this paper,including selection of radionuclide and radiochemical,estimation of radiochemical applied amount,methods of radioisotopic tracer introduced to investigation objects,radioactive sample pretreatment,liquid scintillation counting and radioactive waste treatment.
High Speed Dynamics of Photonic Crystal Nanocavity Laser (2006)

We demonstrated high-speed photonic crystal nanocavity lasers with response time as short as ~2ps and direct modulation speeds exceeding 100 GHz. Such high-speed characteristics are enabled by the use of cavity quantum electrodynamics effects such as strong spontaneous emission rate enhancement
Optische Erfassung dreidimensionaler Strukturen in einem globalen Referenzsystem (2013)

Zusammenfassung Eine Herausforderung bei der Inbetriebnahme von Produktionsprozessen liegt in der Identifikation und Kompensation von Abweichungen zwischen einer virtuellen Planung und der realen Umsetzung. Diese Abweichungen können durch globale Referenzsysteme sichtbar gemacht und kompensiert werden. Dieser Beitrag beschreibt die Integration lokaler Sensorik und deren Daten in einem globalen Referenzsysteme am Beispiel eines flexiblen Lichtschnittsensors bestehend aus mehreren Kameras und einem Mehrlinien-Laserprojektor.
An Industry Overview of Downhole Monitoring Using Distributed Temperature Sensing: Fundamentals and Two Decades Deployment in Oil and Gas Industries (2021)

Abstract Distributed Temperature Sensing (DTS) system using optical fiber has been deployed for downhole monitoring over two-decades. Several technological advancements led to a wide acceptance of this technology as a reliable surveillance technique. This paper presents a comprehensive technical review of all the applications of the DTS, with focus on oil and gas industrial deployments. The paper starts with the advantages of the DTS over other methods and an overview of the DTS basics, including theory, the DTS components, deployment types, fiber types, design and limitations. Then, it is followed by the oil and gas applications of the DTS including hydraulic fracturing (during and after fracturing), well treatment/stimulation (acid injection, fluid distribution, diversion monitoring), inorganic (scaling) and organic (wax/asphaltene/hydrate) deposition detection, leak detection (in well and pipeline), flow monitoring (rate monitoring, water/steam injection and SAGD monitoring, CO2 storage monitoring, zonal contribution determination, gas lift optimization) and reservoir/fluid characterization (facies, porosity, permeability and fluid composition determination). This study reviews the historical development, applications and limitations of the DTS systems. The paper mainly focusses on deployment techniques, the application of the DTS for the prediction and surveillance of the non-thermal and thermal producer/injector wells, hydraulically fractured wells and those wells with treatments. The paper provides a concise review using several field cases from over two hundred published papers of Society of Petroleum Engineering (SPE) and journal databases. The application of the DTS in downhole monitoring can be divided into the qualitative and quantitative applications. In quantitative approaches, numerical models should be combined with the DTS data. This study discusses case by case worldwide field applications of DTS along with proposed modeling methods and interpretations. It also summarizes main challenges, including the fiber reliability, longevity, and operational limitations such as the installation and the complexity of quantitative approaches. This study is the foundation for an ongoing study on wellbore and reservoir surveillance through real-time distributed fiber optic sensing recordings along the wellbore. It summarizes the historical development and limitations to identify the existing gaps and reviews the lessons learned through the two decades of the application of the DTS in production performance.
200 GHz f/sub max/, f/sub τ/ InP/In/sub 0.53/Ga/sub 0.47/As/InP metamorphic double heterojunction bipolar transistors on GaAs substrates (2003)

InP/In/sub 0.53/Ga/sub 0.47/As/InP Double Heterojunction Bipolar Transistors were grown on GaAs substrates using a high-thermal-conductivity InP metamorphic buffer layer. InP metamorphic buffer was selected because it has a large thermal conductivity, which is very important in high power device operation. 200 GHz f/sub max/ and 200 GHz f/sub /spl tau// were obtained. This f/sub max/ is the highest reported for a metamorphic HBT. The breakdown voltage BV/sub CEO/ was 6 V and the DC current gain /spl beta/ was 27. The base-collector reverse leakage current was 54 nA at V/sub CB/ = 0.3V.
Implementation of Quantitative and Systems Pharmacology in Large Pharma (2014)

Quantitative and systems pharmacology concepts and tools are the foundation of the model-informed drug development paradigm at Merck for integrating knowledge, enabling decisions, and enhancing submissions. Rigorous prioritization of modeling and simulation activities has enabled key drug development decisions and led to a high return on investment through significant cost avoidance. Critical factors for the successful implementation, examples on impact on decision making with associated return of investment, and drivers for continued success are discussed.
A Fast Linkage Detection Scheme for Multi-Source Information Integration (2005)

Record linkage refers to techniques for identifying records associated with the same real-world entities. Record linkage is not only crucial in integrating multi-source databases that have been generated independently, but is also considered to be one of the key issues in integrating heterogeneous Web resources. However, when targeting large-scale data, the cost of enumerating all the possible linkages often becomes impracticably high. Based on this background, this paper proposes a fast and efficient method for linkage detection. The features of the proposed approach are: first, it exploits a suffix array structure that enables linkage detection using variable length n-grams. Second, it dynamically generates blocks of possibly associated records using ‘blocking keys’ extracted from already known reliable linkages. The results from our preliminary experiments where the proposed method was applied to the integration of four bibliographic databases, which scale up to more than 10 million records, are also reported in the paper.