gebhart/patrepeval huggingface dataset:
Doxorubicin impacts chromatin binding of HMGB1, Histone H1 and retinoic acid receptor (2022)

Doxorubicin (Dox), a widely used anticancer DNA-binding drug, affects chromatin in multiple ways, and these effects contribute to both its efficacy and its dose-limiting side effects, especially cardiotoxicity. Here, we studied the effects of Dox on the chromatin binding of the architectural proteins high mobility group B1 (HMGB1) and the linker histone H1, and the transcription factor retinoic acid receptor (RARα) by fluorescence recovery after photobleaching (FRAP) and fluorescence correlation spectroscopy (FCS) in live cells. At lower doses, Dox increased the binding of HMGB1 to DNA while decreasing the binding of the linker histone H1. At higher doses that correspond to the peak plasma concentrations achieved during chemotherapy, Dox reduced the binding of HMGB1 as well. This biphasic effect is interpreted in terms of a hierarchy of competition between the ligands involved and Dox-induced local conformational changes of nucleosome-free DNA. Combined, FRAP and FCS mobility data suggest that Dox decreases the overall binding of RARα to DNA, an effect that was only partially overcome by agonist binding. The intertwined interactions described are likely to contribute to both the effects and side effects of Dox.
Caracterización de un sistema de verificación de dosis dedicado a tratamientos de radioterapia basado en un detector de tiras de silicio (2011)

Trabajo presentado al 2º congreso conjunto de las Sociedades Españolas de Física Médica y de Protección Radiológica (XVIII Congreso Nacional SEFM/XIII Congreso Nacional de SEPR) celebrado en Sevilla del 10 al 13 de Mayo de 2011.-- et al.
Delphi consensus recommendations for a treatment algorithm in pulmonary sarcoidosis (2020)

Pulmonary sarcoidosis presents substantial management challenges, with limited evidence on effective therapies and phenotypes. In the absence of definitive evidence, expert consensus can supply clinically useful guidance in medicine. An international panel of 26 experts participated in a Delphi process to identify consensus on pharmacological management in sarcoidosis with the development of preliminary recommendations.The modified Delphi process used three rounds. The first round focused on qualitative data collection with open-ended questions to ensure comprehensive inclusion of expert concepts. Rounds 2 and 3 applied quantitative assessments using an 11-point Likert scale to identify consensus.Key consensus points included glucocorticoids as initial therapy for most patients, with non-biologics (immunomodulators), usually methotrexate, considered in severe or extrapulmonary disease requiring prolonged treatment, or as a steroid-sparing intervention in cases with high risk of steroid toxicity. Biologic therapies might be considered as additive therapy if non-biologics are insufficiently effective or are not tolerated with initial biologic therapy, usually with a tumour necrosis factor-α inhibitor, typically infliximab.The Delphi methodology provided a platform to gain potentially valuable insight and interim guidance while awaiting evidenced-based contributions.
Research Reactor Benchmarks (2003)

A criticality benchmark experiment performed at the Jozef Stefan Institute TRIGA Mark II research reactor is described. This experiment and its evaluation are given as examples of benchmark experiments at research reactors. For this reason the differences and possible problems compared to other benchmark experiments are particularly emphasized. General guidelines for performing criticality benchmarks in research reactors are given. The criticality benchmark experiment was performed in a normal operating reactor core using commercially available fresh 20% enriched fuel elements containing 12 wt% uranium in uranium-zirconium hydride fuel material. Experimental conditions to minimize experimental errors and to enhance computer modeling accuracy are described. Uncertainties in multiplication factor due to fuel composition and geometry data are analyzed by sensitivity analysis. The simplifications in the benchmark model compared to the actual geometry are evaluated. Sample benchmark calculations with the MCNP and KENO Monte Carlo codes are given.
Link-based Approaches for Text Retrieval. (2001)

We assess a family of ranking mechanisms for search engines based on linkage analysis using a carefully engineered subset of the World Wide Web, WT10g (Bailey, Craswell and Hawking 2001), and a set of relevance judgements for 50 different queries from Trec-9 to evaluate the performance of several link-based ranking techniques. Among these link-based algorithms, Kleinberg&amp;apos;s HITS and Larry Page and Sergey Brin&amp;apos;s PageRank are assessed. Link analysis seems to yield poor results in Trec&amp;apos;s Web Ad Hoc Task. We suggest some alternative algorithms which reuse both text-based search similarity measures and linkage analysis. Although these algorithms yield better results, improving text-only search recall-precision curves in the Web Ad Hoc Task remains elusive; only a certain category of queries seems to benefit from linkage analysis. Among these queries, homepage searches may be good candidates.
Highly Efficient Oxygen Reduction Reaction Electrocatalysts Synthesized under Nanospace Confinement of Metal–Organic Framework (2017)

The output energy capacity of green electrochemical devices, e.g., fuel cells, depends strongly on the sluggish oxygen reduction reaction (ORR), which requires catalysts. One of the desired features for highly efficient ORR electrocatalytic materials is the richness of well-defined activate sites. Herein, we developed a facile approach to prepare highly efficient nonprecious metal and nitrogen-doped carbon-based ORR catalysts based on covalent organic polymers (COPs) synthesized in situ in the nanoconfined space of highly ordered metal organic frameworks (MOFs). The MOF templet ensured the developed electrocatalysts possess a high surface area with homogeneously distributed small metal/nitrogen active sites, as confirmed by X-ray absorption fine structure measurements and first-principles calculations, leading to highly efficient ORR electrocatalytic activity. Notably, the developed COP-TPP(Fe)@MOF-900 exhibits a 16 mV positive half-wave potential compared with the benchmarked Pt/C.
Utilization of an Asphalt Pavement Analyzer for Hot Mix Asphalt Laboratory Mix Design (2006)

The Superpave volumetric mix design system, developed by SHRP in the 1990s, has continued to gain widespread acceptance across the United States. Although it is widely believed to be an improvement over past mix design systems, it does have an inherent flaw. It does not include a performance test to assess HMA's resistance to rutting, fatigue, or low temperature cracking. With the development and implementation of newer performance test specifications, it is an appropriate time to work on integrating a performance based test for construction specifications. Rather than being based on material properties or construction practices, the payment for an HMA pavement could then be based primarily on the performance based specification. The results of this study indicate that although the APA works well as the pass/fail criterion used by state agencies, the variability of APA cycles to failure make it impractical to base a rut prediction model on data obtained from it.
HLA‐DR1 and rheumatoid arthntis in Israeli Jews: Sequencing reveals that DRB1*0102 is the predominant HLA‐DR1 subtype (1993)

Rheumatoid arthritis (RA) is associated with the HLA-DR4 cellular subtypes Dw4 and Dw14 in Caucasians, with Dw15 in Japanese, and possibly with HLA-DR1 in Israeli Jews. Sequencing studies in Caucasians have shown that these molecules share a common amino acid sequence in the third hypervariable region of the DR molecule (AA 67-74: LLEQRRAA or LLEQKRAA), suggesting that this sequence is primarily associated with RA. An important argument in favor of this shared-epitope hypothesis has been the reported association between DR1 and RA in Israeli Jews. However, a later report did not confirm this association, and cellular typing showed that Israeli DR1 consists of three or more subtypes, suggesting that new subtypes might be present. Since no sequencing data on Israeli HLA-DR1 genes have been reported, we sequenced the first domain (AA 10-91) of the DRB1 gene in 12 DR1-positive Israeli RA patients, 5 healthy controls and a homozygous typing cell (HTC), defining the major Jewish cellular HLA-DR1 subtype. DRB1*0102 (DR1 Dw20) was found in 8 RA patients, 3 controls and the HTC "LVA". DRB1*0101 (DR1 Dw1) was found in 4 RA patients and 2 controls. No other DR1 subtypes were encountered. In all 20 DR1 haplotypes, the DRB1*0101 or 0102 allele was associated with DQA1*0101 and DQB1*0501, being identical to the Caucasian DR1 haplotypes. Thus, at the sequence level, we found no basis for the reported extensive cellular heterogeneity of DR1 in the Israeli population.(ABSTRACT TRUNCATED AT 250 WORDS)
Ligand field stabilization in nickel complexes that exhibit extraordinary glass transition temperature enhancement (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLigand field stabilization in nickel complexes that exhibit extraordinary glass transition temperature enhancementLaurence A. Belfiore, Hugh Graham, and Eiji UedaCite this: Macromolecules 1992, 25, 11, 2935–2939Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/ma00037a023https://doi.org/10.1021/ma00037a023research-articleACS PublicationsRequest reuse permissionsArticle Views358Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Cesar computer architecture: A programmable array processor for space applications (1993)

This paper describes the Cesar computer system in terms of architecture, programming environment, and applications. The architecture introduces a programmable hardware implementation approach to algorithms through high order library functions, callable from a Unix environment. Parallelism with no communication overhead is achieved, providing high performance in vector computations. The system has proven to be very effective for signal processing tasks as well as for classes of numerical applications. The system is compact and air‐cooled, and the performance growth potential is considered as very promising. The nature of the architecture makes the system interesting both as an applicator specific supercomputer and as a custom configurable system for embedded applications.
Efficient Co-generation of Seventh-Harmonic Radiation in Cyclotron Autoresonance Acceleration (1996)

It is shown that the lowest ${\mathrm{TE}}_{s,l}$ mode in a cylindrical waveguide at frequency $s\ensuremath{\omega}$, with group velocity nearly identical to group velocity for the ${\mathrm{TE}}_{11}$ mode at frequency $\ensuremath{\omega}$, is that with $s\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}7$, $l\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}2$. This allows coherent radiation to be generated at the seventh harmonic during electron cyclotron autoresonance acceleration. Conditions are found where such co-generation of 7th harmonic power at 20 GHz is possible with overall efficiency greater than 80%. This mechanism could make possible high efficiency cm-wavelength high power rf sources suitable for driving a future multi-TeV electron-position collider.
PET of Aromatase in Gastric Parietal Cells Using 11C-Vorozole (2011)

Aromatase is a rate-limiting enzyme for estrogen biosynthesis and has been implicated in pathophysiological states of various diseases via estrogen production. This enzyme is known to be widely distributed in extragonadal and gonadal tissues including the stomach. In contrast to circulating estrogen, the functional role of gastric aromatase/estrogen has not been elucidated in detail, because there is no efficient methodology to investigate spatiotemporal changes of gastric aromatase/estrogen in vivo. Recently, (<i>S</i>)-<sup>11</sup>C-6-[(4-chlorophenyl)(1<i>H</i>-1,2,4-triazole-1-yl)methyl]-1-methyl-1<i>H</i>-benzotriazole (<sup>11</sup>C-labeled vorozole), based on a potent nonsteroidal aromatase inhibitor, has been developed as a tracer to investigate aromatase distribution in living animals and humans using a noninvasive PET technique. In the present study, we investigated gastric aromatase expression by means of PET with <sup>11</sup>C-vorozole. <b>Methods:</b> After bolus injection of <sup>11</sup>C-vorozole into the tail vein, emission scans were obtained for 90 min on male and female rats under isoflurane anesthesia. Displacement studies with unlabeled vorozole and autoradiographic analysis were conducted for demonstration of specific binding. Immunohistochemistry was performed to confirm aromatase expression. <b>Results:</b> PET scans revealed that <sup>11</sup>C-vorozole highly accumulated in the stomach and adrenal glands. Displacement studies and autoradiography demonstrated that aromatase was expressed in the stomach but that the accumulation of <sup>11</sup>C-vorozole in the adrenal glands might be through nonspecific binding. Immunohistochemical analysis revealed that aromatase is expressed in gastric parietal cells but not in adrenal glands. Moreover, the accumulation of <sup>11</sup>C-vorozole in the stomach was significantly increased in fatigued rats. <b>Conclusion:</b> These results suggest that the <sup>11</sup>C-vorozole PET technique is a useful tool for evaluation of gastric aromatase dynamics in vivo, which may provide important information for understanding the molecular mechanisms of gastric aromatase/estrogen–related pathophysiological processes and for the development of new drugs.
PD20-07 THE PAINFUL PELVIC SYMPTOMS IN AGING MEN. THE RESULTS OF POPULATION-BASED SAMPLE OF MEN (2016)

often omitted from studies on genital chlamydia infection, resulting in limited availability of their epidemiological data. Chlamydia ompA gene has unique regions for evading host immunity. Therefore, certain ompA genotype may have a selective advantage for its survival. In this study, we evaluated the patterns of urinary chlamydia ompA genotypes in men who visited the clinic with or without symptoms and signs of urethritis and investigated the effects of different genotypes on clinical features.
Evaluation of the efficacy of thiamine and pyridoxine in the treatment of symptomatic diabetic peripheral neuropathy. (1997)

The clinical response to therapeutic doses of two vitamins were determined in diabetic patients with symptomatic peripheral neuropathy. Of 200 consecutive patients, 100 were randomly allocated to treatment with both thiamine (25 mg/day) and pyridoxine (50 mg/day) group A and the rest group B to treatment with an identical tablet containing 1 mg/day each of thiamine and pyridoxine. Pain, numbness, paraesthesia and impairment of sensation and ankle in the legs were graded into none, mild, moderate or severe. Blood thiamine levels were measured using HPLC fluorimetry. Four weeks after starting treatment the grade was less than on the first visit in 88.9%, 82.5% and 89.7% of those whose worst symptoms were pain, numbness and paraesthesia respectively for group A compared with 11.1%, 40.5% and 39.4% respectively for group B. The severity of signs of peripheral neuropathy decreased in 48.9% of patients in group A compared with 11.4% in group B. The mean (s.e.) pre-treatment whole blood thiamine levels decreased with increasing severity of symptoms: 64.2 (2.81), 57.7 (3.25) and 52.2 (2.14) micrograms/l for those with mild, moderate and severe symptoms respectively (analysis of variance, p = 0.03). Diabetic peripheral neuropathy in Dar es Salaam is associated with thiamine deficiency. Dietary guidelines for diabetic patients should emphasize a balanced diet.
Superconducting Behavior of Pressure-Induced Zirconium Polymorph (1964)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation B. Tittmann, D. Hamilton, A. Jayaraman; Superconducting Behavior of Pressure‐Induced Zirconium Polymorph. J. Appl. Phys. 1 March 1964; 35 (3): 732–733. https://doi.org/10.1063/1.1713453 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioJournal of Applied Physics Search Advanced Search |Citation Search
[(3,5-(CF3)2C6H3)4B]-[H(OEt2)2]+: a convenient reagent for generation and stabilization of cationic, highly electrophilic organometallic complexes (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT[(3,5-(CF3)2C6H3)4B]-[H(OEt2)2]+: a convenient reagent for generation and stabilization of cationic, highly electrophilic organometallic complexesM. Brookhart, B. Grant, and A. F. Volpe Jr.Cite this: Organometallics 1992, 11, 11, 3920–3922Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/om00059a071https://doi.org/10.1021/om00059a071research-articleACS PublicationsRequest reuse permissionsArticle Views10967Altmetric-Citations812LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dietary catechins in relation to coronary heart disease death among postmenopausal women (2001)

Catechins, one of the major groups of flavonoids, are bioactive compounds present in a variety of plant foods and beverages. Experimental data suggest that they might prevent chronic diseases in humans. We studied whether the intake of catechins was inversely associated with the risk of coronary heart disease death in a prospective study of postmenopausal women from Iowa. Between 1986 and 1998, 767 of 34,492 participants initially free of cardiovascular diseases died from coronary heart disease. There was a strong inverse association between the intake of (+)-catechin and (-)-epicatechin and coronary heart disease death, which was somewhat attenuated after multivariate adjustment (risk ratios from lowest to highest quintile: 1.00, 0.95, 0.97, 0.77, 0.76). This inverse association was most pronounced in women at low risk of coronary heart disease (non-smokers, free of diabetes mellitus and cardiovascular diseases). A high intake of "gallates," catechins typical of tea, was not associated with coronary heart disease death. Of the major catechin sources, apples and wine were inversely associated with coronary heart disease death. Our data suggest that preventive effects might be limited to certain types of catechins, or that these are indicators of other dietary components or a healthy lifestyle in general.
Musculoskeletal Symptomnatology and Repetitive Strain Injuries in Diagnostic Medical Sonographers (1996)

Repetitive strain injuries are beginning to be widely recognized as a serious occupational risk for sonographers. The goal of this study was to establish the incidence of musculoskeletal symptomatology and repetitive strain injuries in sonographers from Washington state and Oregon and to correlate certain physical attributes, work load, and work habits with the reporting rates of musculoskeletal symptomatology and repetitive strain injuries. The data for this study were gathered through a comprehensive questionnaire. Eighteen percent of respondents suffered no symptoms; 66% suffered symptoms without repetitive strain injury, and 15% were diagnosed with repetitive strain injury. The analysis revealed that a positive correlation exists between certain ergonomically unsound work habits and increased symptomatology. The proportion of repetitive strain injury-diagnosed sonographers tended to increase with more years in the profession. The reporting rate of musculoskeletal symptomatology and repetitive strain injuries also appeared to be influenced by other variables, such as gender, work load, and stress in the workplace.
Closed-loop DBS triggered by real-time movement and tremor decoding based on thalamic LFPs for essential tremor (2020)

High frequency Deep Brain Stimulation (DBS) targeting the motor thalamus is an effective therapy for essential tremor (ET). However, since tremor mainly affects periods of voluntary movements and sustained postures in ET, conventional continuous stimulation may deliver unnecessary current to the brain. Here we tried to decode movement states based on local field potentials (LFPs) recorded from motor thalamus and zona incerta in real-time to trigger the switching on and off of DBS in three patients with ET. Patient-specific models were first identified using thalamic LFPs recorded while the patient performed movements that tended to trigger tremor in everyday life. During the real-time test, LFPs were continuously recorded to decode movements and tremor, and the detection triggered stimulation. Results show that voluntary movements can be detected with a mean sensitivity ranging from 76.8% to 88.6% and a false positive rate ranging from 16.0% to 23.1% Postural tremor was detected with similar accuracy. The closed-loop DBS triggered by tremor detection suppressed intention tremor by 90.5% with a false positive rate of 20.3%.Clinical Relevance- This is the first study on closed-loop DBS triggered by real-time movement and tremor decoding based solely on thalamic LFPs. The results suggest that responsive DBS based on movement and tremor detection can be achieved without any requirement for external sensors or additional electrocorticography strips.