gebhart/patrepeval huggingface dataset:
Leptin and leptin receptor genotypes and colon cancer: Gene–gene and gene–lifestyle interactions (2007)

Leptin may play an important role in colorectal cancer because of its role in energy balance, insulin and inflammation. We evaluated the LEP rs2167270 (19 G > A) and rs7799039 (-2548 G > A) polymorphisms and the leptin receptor, LEPR rs6588147 (located in intron 2), polymorphism with risk of developing colon cancer in a study of 1,567 cases and 1,965 controls. We evaluated the effects of the polymorphisms with body mass index (BMI), recent use of aspirin/NSAIDs and genetic variations in genes related to insulin signaling pathways including insulin-like growth factor 1 (IGF1), insulin-like growth factor binding protein 3 (IGFBP3), and insulin-related substrates 1 and 2 (IRS1, IRS2) and the vitamin D receptor (VDR). We observed a slight reduction in colon cancer risk with the AA LEP rs2167270 genotype (OR 0.79 95% CI 0.64, 0.98) and although not reaching statistical significance, with the combined GG LEP rs2167270 and GG LEPR rs6588147 (OR 0.70, 95% CI 0.49, 1.02) genotypes. BMI did not interact with any of these polymorphisms to alter colon cancer risk. However, recent aspirin/NSAID use significantly interacted with both LEP polymorphisms. Likewise, variants of IGF1 and IRS2 interacted with the LEP rs2167270 polymorphism. VDR polymorphisms interacted with all LEP and LEPR polymorphisms. These data support an association between LEP and colon cancer. They also suggest that the mechanisms linking leptin to colon cancer may be independent of energy balance.
Human immunodeficiency virus type 1 preintegration complexes containing discontinuous plus strands are competent to integrate in vitro (1995)

Despite intensive study, the mechanism by which many retroviruses complete reverse transcription has remained unclear. Most retroviruses and all lentiviruses fail to synthesize a full-length second strand of the viral cDNA (plus strand) efficiently in infected cells. For human immunodeficiency virus type 1, we find in synchronous infection experiments that full-length plus strands are rare (< 1% of products) at times when integration is likely taking place. Subviral nucleoprotein complexes containing such discontinuous cDNA can be extracted from infected cells and used to generate integration products in vitro. Analysis of such integration products using two-dimensional gel electrophoresis revealed that the discontinuous viral DNA was efficiently integrated into an added target DNA. These data support a model in which the discontinuities in the plus strand need not be sealed until after integration, potentially by the enzymes that are already thought to repair DNA gaps at the junctions between host and viral DNA.
Precision Beam Location (1971)

A method for precise positioning of a beam on a given target is described. The technique employs a time dependent bias applied to the relative target beam position and frequency tuned detection of an associated flux that is coherently sensitive to changes in the primary beam. A location reference is determined which is the centroid of the convolution product of the target shape function and the beam profile function.
Double‐frequency buck converter as a candidate topology for integrated envelope elimination and restoration applications in power supply of RFPAs (2015)

Summary This paper proposes the use of double‐frequency (DF) buck converter architecture consisting of a merged structure of high and low frequency buck cells as a candidate topology for envelope elimination and restoration (EER) applications and integrated power supply of RF power amplifiers (RFPA) to obtain favorable tradeoffs in terms of efficiency, switching ripple, bandwidth, and tracking capability. It is shown that having two degrees of freedom in designing the DF buck helps to achieve high efficiency, low output ripples, and tracking capability with low ripples, simultaneously. A comparison analysis is done with regards to the mentioned performance indexes with the standard and three‐level buck converters; in addition, the results are validated in HSPICE in BSIM3V3 0.35‐µm CMOS process. Copyright © 2015 John Wiley &amp; Sons, Ltd.
Abstract 20561: Correlation Between Transmitral Vortex Formation and Mitral Valve's Leaflet Length (2010)

Background: Several studies have previously confirmed the presence of vortical flow structures that develop along with the propulsive transmitral jet. These vortices are found as indicator of diastolic function. Recent works also report that in a normal heart, the transmitral vortex tends to be more asymmetric than symmetric potentially due to asymmetry of the mitral valve's leaflets. In the present work, we have studied the effect of mital valve leaflets' length on the shape of the transmitral vortex using a dynamic bi-leaflet mitral bioprosthesis. Methods: This study has been accomplished using a left heart pulsed flow simulator. Two bi-leaflet mitral bioprosthetics (25mm) with different leaflet lengths (11mm and 25mm) that mimic the dynamic motion of the mitral valve's saddle annulus were used for comparison. The flow characteristic information was captured by high speed Digital Particle Image Velocimetry (DPIV). Results: Flow fields downstream of each valve were mapped using DPIV. Figures A and B show...
Anti‐β2M monoclonal antibodies kill myeloma cells via cell‐ and complement‐mediated cytotoxicity (2014)

Our previous studies showed that anti-β2M monoclonal antibodies (mAbs) at high doses have direct apoptotic effects on myeloma cells, suggesting that anti-β2M mAbs might be developed as a novel therapeutic agent. In this study, we investigated the ability of the mAbs at much lower concentrations to indirectly kill myeloma cells by utilizing immune effector cells or molecules. Our results showed that anti-β2M mAbs effectively lysed MM cells via antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), which were correlated with and dependent on the surface expression of β2M on MM cells. The presence of MM bone marrow stromal cells or addition of IL-6 did not attenuate anti-β2M mAb-induced ADCC and CDC activities against MM cells. Furthermore, anti-β2M mAbs only showed limited cytotoxicity toward normal B cells and nontumorous mesenchymal stem cells, indicating that the ADCC and CDC activities of the anti-β2M mAbs were more prone to the tumor cells. Lenalidomide potentiated in vitro ADCC activity against MM cells and in vivo tumor inhibition capacity induced by the anti-β2M mAbs by enhancing the activity of NK cells. These results support clinical development of anti-β2M mAbs, both as a monotherapy and in combination with lenalidomide, to improve MM patient outcome.
A modeling approach to federated identity and access management (2005)

As the Web is increasingly used as a platform for heterogeneous applications, we are faced with new requirements to authentication, authorization and identity management. Modern architectures have to control access not only to single, isolated systems, but to whole business-spanning federations of applications and services. This task is complicated by the diversity of today's specifications concerning e.g. privacy, system integrity and distribution in the web. As an approach to such problems, in this paper, we introduce a solution catalogue of reusable building blocks for Identity and Access Management (IAM). The concepts of these blocks have been realized in a configurable system that supports IAM solutions for Web-based applications.
Evaluating network cyber resiliency methods using cyber threat, Vulnerability and Defense Modeling and Simulation (2012)

This paper describes a Cyber Threat, Vulnerability and Defense Modeling and Simulation tool kit used for evaluation of systems and networks to improve cyber resiliency. This capability is used to help increase the resiliency of networks at various stages of their lifecycle, from initial design and architecture through the operation of deployed systems and networks. Resiliency of computer systems and networks to cyber threats is facilitated by the modeling of agile and resilient defenses versus threats and running multiple simulations evaluated against resiliency metrics. This helps network designers, cyber analysts and Security Operations Center personnel to perform trades using what-if scenarios to select resiliency capabilities and optimally design and configure cyber resiliency capabilities for their systems and networks.
Amyloid Structures as Biofilm Matrix Scaffolds (2016)

Recent insights into bacterial biofilm matrix structures have induced a paradigm shift toward the recognition of amyloid fibers as common building block structures that confer stability to the exopolysaccharide matrix. Here we describe the functional amyloid systems related to biofilm matrix formation in both Gram-negative and Gram-positive bacteria and recent knowledge regarding the interaction of amyloids with other biofilm matrix components such as extracellular DNA (eDNA) and the host immune system. In addition, we summarize the efforts to identify compounds that target amyloid fibers for therapeutic purposes and recent developments that take advantage of the amyloid structure to engineer amyloid fibers of bacterial biofilm matrices for biotechnological applications.
Synthesis, Optical Resolution, and X-ray Crystal Structure of a Helical Hexaazamacrocyclic Zinc Complex (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, Optical Resolution, and X-ray Crystal Structure of a Helical Hexaazamacrocyclic Zinc ComplexL. Henry Jr. Bryant, Abdessadek Lachgar, Kimberly S. Coates, and Susan C. JackelsCite this: Inorg. Chem. 1994, 33, 10, 2219–2226Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://doi.org/10.1021/ic00088a026RIGHTS & PERMISSIONSArticle Views110Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (887 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Robust incremental rectification of sports video sequences (2004)

We describe an important element of an automatic sport analysis system.This element continuously estimates the image-to-model homography from the video stream of a single camera.Here, we focus on the incremental image-to-image updating of the homography matrix, which greatly facilitates real-time operation.This updating relies on the automatic tracking of interest lines and points and on their use for robust homography estimation.Results on real video sequences are shown.
Orientational dependence of the interface magnetic anisotropy in epitaxial Ni/Co/Ni sandwiches (1992)

Magneto-optical Kerr effect measurements have been used to investigate the orientational dependence of the magnetic anisotropy in ultrathin Ni/Co-wedge/Ni sandwiches deposited by molecular beam epitaxy on single-crystal Cu substrates. The results show a marked dependence of both the volume and interface anisotropy terms on the growth direction of the samples: [100], [110], and [111]. In addition, the (111) interface term was found to be significantly larger than existing literature values for Co/Ni multilayers. This effect is discussed in terms of the microstructure of the studied films.
Zusammenhang zwischen physikalischer struktur und textilen eigenschaften von faserneuentwicklungen (1974)

Abstract Mit einer Reihe physikalische Meßverfahren, insbesondere der Röntgenweit‐ und ‐kleinwinkelstreuung kann die übermolekulare Struktur von Synthesefäden ermittelt werden. Aus der Reihe der aromatischen Polyamide lassen sich überwiegend amorphe Fäden mit hoher Wasseraufnahme herst̀ellen, während andere Fäden durch einen extrem hohen Elastizitätsmodul gekennzeichnet sind. Polypropylen‐ und Polypivalolactonfäden mit einer durch das Herstellverfahren bedingten mikromorphologischen Lamellenstruktur besitzen den Charakter von Elastomerfäden.
Structural approach for Ca(PO3)2-NaPO3-B2O3 composition glasses (2004)

The structure of glasses in the system Ca(PO3)2– NaPO3–B2O3 has been investigated using Raman and NMR (31P MAS, 11B) measurements. For calcium borophosphates of composition (1-x)Ca(PO3)2.xB2O3 (0£x£0·6), structural models are proposed for glasses of varying x. In the phosphate rich compositional domain (0
Bias Dependence of Total Ionizing Dose Effects on 28-nm Bulk MOSFETs (2018)

This paper investigates the effects of total ionizing dose up to 1 Grad on 28-nm bulk MOSFETs under different bias conditions during irradiation. The aim is to assess the potential use of this commercial bulk CMOS technology in the future high-luminosity Large Hadron Collider at CERN that will require highly improved radiation-tolerant tracking systems.
Supplementary Figure 5 from Hsp90 Inhibition Suppresses Mutant EGFR-T790M Signaling and Overcomes Kinase Inhibitor Resistance (2023)

Supplementary Figure 5 from Hsp90 Inhibition Suppresses Mutant EGFR-T790M Signaling and Overcomes Kinase Inhibitor Resistance
Temperature dependence of soft-error rates for FF designs in 20-nm bulk planar and 16-nm bulk FinFET technologies (2016)

Alpha particle-induced flip-flop soft-error rates (SER) for 20-nm bulk planar and 16-nm bulk FinFET technologies are characterized over temperature with different supply voltages. Experimental results indicate that the 16-nm FinFET SER changes insignificantly with temperature while the 20-nm planar SER increases by ∼2x over the same temperature range. 3D TCAD and circuit-level simulations show changes in single-event transient (SET) pulse width and logic gate delay are the controlling factors, with opposing influences on SER.
Supplementary Video S1_NME1 from Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis (2023)

&lt;p&gt;Endocytosis of pHrodo Red-EGF in NME1 expressing cells&lt;/p&gt;
Hypoxia Potentiates Glioma-Mediated Immunosuppression (2011)

Glioblastoma multiforme (GBM) is a lethal cancer that exerts potent immune suppression. Hypoxia is a predominant feature of GBM, but it is unclear to the degree in which tumor hypoxia contributes to this tumor-mediated immunosuppression. Utilizing GBM associated cancer stem cells (gCSCs) as a treatment resistant population that has been shown to inhibit both innate and adaptive immune responses, we compared immunosuppressive properties under both normoxic and hypoxic conditions. Functional immunosuppression was characterized based on production of immunosuppressive cytokines and chemokines, the inhibition of T cell proliferation and effector responses, induction of FoxP3+ regulatory T cells, effect on macrophage phagocytosis, and skewing to the immunosuppressive M2 phenotype. We found that hypoxia potentiated the gCSC-mediated inhibition of T cell proliferation and activation and especially the induction of FoxP3+T cells, and further inhibited macrophage phagocytosis compared to normoxia condition. These immunosuppressive hypoxic effects were mediated by signal transducer and activator of transcription 3 (STAT3) and its transcriptionally regulated products such as hypoxia inducible factor (HIF)-1a and vascular endothelial growth factor (VEGF). Inhibitors of STAT3 and HIF-1a down modulated the gCSCs' hypoxia-induced immunosuppressive effects. Thus, hypoxia further enhances GBM-mediated immunosuppression, which can be reversed with therapeutic inhibition of STAT3 and HIF-1a and also helps to reconcile the disparate findings that immune therapeutic approaches can be used successfully in model systems but have yet to achieve generalized successful responses in the vast majority of GBM patients by demonstrating the importance of the tumor hypoxic environment.
Effect of polysilicon depletion charge on electron mobility in ultrathin oxide MOSFETs (2003)

We studied the effect of the depletion charge in the polysilicon gate on electron mobility in ultrathin oxide MOSFETs. An improved theory for remote-charge-scattering-limited mobility in silicon inversion layers is developed. The model takes into account the effects of image charges, screening, inversion layer quantization, the contribution of different subbands, oxide thickness, the actual distribution of charged centres inside the structure, the actual distribution of carriers in the inversion layer, the correlation of charged centres and the charged centre sign. It is shown that if the oxide is thin enough the remote Coulomb scattering due to the depletion charge in the poly-gate becomes an effective scattering mechanism, whose effect is comparable to those of the main scattering mechanisms that control the movement of the carriers in the MOSFET channel. As a consequence, this scattering mechanism must be taken into account in order to satisfactorily explain the experimental results obtained in ultrathin oxide MOSFETs. The model is implemented in a Monte Carlo simulator, where the effects of the ionized impurity charge in the substrate, the interface trapped charge and the contribution of other scattering mechanisms are taken into account simultaneously. Our results show that RCS cannot be neglected for oxide thicknesses below 2 nm, but that its effects for tox > 5 nm are negligible. Good agreement with experimental results was obtained.
TheDrosophilaF-box protein dSkp2 regulates cell proliferation by targeting Dacapo for degradation (2013)

Cell cycle progression is controlled by a complex regulatory network consisting of interacting positive and negative factors. In humans, the positive regulator Skp2, an F-box protein, has been a subject of intense investigation in part because of its oncogenic activity. By contrast, the molecular and developmental functions of its Drosophila homologue, dSkp2, are poorly understood. Here we investigate the role of dSkp2 by focusing on its functional relationship with Dacapo (Dap), the Drosophila homologue of the cyclin-dependent kinase inhibitors p21(cip1)/p27(kip1)/p57(kip2). We show that dSkp2 interacts physically with Dap and has a role in targeting Dap for ubiquitination and proteasome-mediated degradation. We present evidence that dSkp2 regulates cell cycle progression by antagonizing Dap in vivo. dSkp2 knockdown reduces cell density in the wing by prolonging the cell doubling time. In addition, the wing phenotype caused by dSkp2 knockdown resembles that caused by dap overexpression and can be partially suppressed by reducing the gene dose of dap. Our study thus documents a conserved functional relationship between dSkp2 and Dap in their control of cell cycle progression, suggesting the possibility of using Drosophila as a model system to study Skp2-mediated tumorigenesis.
Noninvasive Lifting of Arm, Thigh, and Knee Skin with Transcutaneous Intense Focused Ultrasound (2012)

Transcutaneous intense focused ultrasound can be safely and effectively used to improve the clinical appearance (texture and contour) of the upper arms, extensor knees, and medial thighs.
Treatment of 94 Outpatients With Chronic Discogenic Low Back Pain with the DRX9000: A Retrospective Chart Review (2008)

This retrospective chart audit provides preliminary data that chronic LBP may improve with DRX9000 spinal decompression. Randomized double-blind trials are needed to measure the efficacy of such systems.
Demonstration of nonlinear tuning curve vibration of granular medium supported by a clamped circular elastic plate using a soil plate oscillator (2017)

A demonstration will be conducted in order to show how a soil plate oscillator (SPO) filled with granular material will create a nonlinear system due to shifting peaks in a tuning curve with incremental increases in the swept drive amplitude. An SPO has two flanges clamping an elastic plate which supports a circular column of granular material. The plate (with a magnet and accelerometer fastened to the underside) is driven below by an amplified swept sinusoidal current applied to an AC coil. Past results have used masonry sand, granular edible uncooked materials, and glass beads in order to study the nonlinear tuning curve response near a resonance with (1) a fixed soil column while changing drive amplitude and (2) mass loading of a soil column versus the resonant frequency response of the system at a fixed drive amplitude. When the experiments are performed at a fixed drive but with a changing mass layer the resonant frequency increases then decreases with increased added mass due to an increase in flexural rigidity of the granular media disk layer which dominates the effect of adding mass. SPO tuning curves resemble the nonlinear mesoscopic elastic behavior of resonant effects of geomaterials such as sandstone.
Thalassobacter arenae sp. nov., isolated from sea sand in Korea (2009)

A Gram-negative, short rod-shaped bacterium, strain GA2-M15(T), was isolated from a sea-sand sample at Homi Cape, Pohang city, Republic of Korea. 16S rRNA gene sequence analysis demonstrated that this isolate was unique, showing 95.9 % sequence similarity to the type strain of Thalassobacter stenotrophicus and similarities of 94.0-95.2 % to the type strains of species of the genera Octadecabacter (94.4-95.2 %), Jannaschia (94.0-94.4 %) and Thalassobius (94.0-94.7 %). Chemotaxonomic characteristics (diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine and phosphatidylcholine as the major polar lipids and C(18 : 1)omega7c as the predominant fatty acid) and DNA G+C content (56 mol%) were also similar to those of Thalassobacter stenotrophicus. 16S rRNA gene sequence similarity, physiological properties and some fatty acid components showed that strain GA2-M15(T) could be differentiated from Thalassobacter stenotrophicus. On the basis of these results, strain GA2-M15(T) is considered to represent a novel species of the genus Thalassobacter, for which the name Thalassobacter arenae sp. nov. is proposed. The type strain is GA2-M15(T) (=KACC 12675(T) =DSM 19593(T)).
Distinct Laser Dynamics from a Single Figure-Eight Laser with an Integrated Nonlinear Waveguide (2020)

We report a passive mode-locked laser system using a nonlinear amplifying loop mirror configuration with an integrated waveguide, capable of delivering different temporal pulse profiles with adjustable features from a single compact architecture.