gebhart/patrepeval huggingface dataset:
Detecting DNS Tunnels Using Character Frequency Analysis (2010)

High-bandwidth covert channels pose significant risks to sensitive and proprietary information inside company networks. Domain Name System (DNS) tunnels provide a means to covertly infiltrate and exfiltrate large amounts of information passed network boundaries. This paper explores the possibility of detecting DNS tunnels by analyzing the unigram, bigram, and trigram character frequencies of domains in DNS queries and responses. It is empirically shown how domains follow Zipf's law in a similar pattern to natural languages, whereas tunneled traffic has more evenly distributed character frequencies. This approach allows tunnels to be detected across multiple domains, whereas previous methods typically concentrate on monitoring point to point systems. Anomalies are quickly discovered when tunneled traffic is compared to the character frequency fingerprint of legitimate domain traffic.
Articulatory Movements During Vowels in Speakers With Dysarthria and Healthy Controls (2008)

Differences in severity between the speakers with PD and ALS may have accounted for some of the differences in movement characteristics between the groups. These factors need to be carefully considered when describing the nature of speech disorder and developing empirically based evaluation and treatment strategies for dysarthria.
On Supramolecular Polymerization: Interview with Takuzo Aida (2019)

Prof. Takuzo Aida is one of the most visible materials chemists thanks to his many creative contributions to the broad field of supramolecular chemistry. Over the past two decades he has ingeniously utilized self-assembly across scales and between various components to access a breathtaking variety of complex materials with fascinating properties. For example, the Aida Lab has pioneered conducting "bucky gel" by dispersing carbon nanotubes in ionic liquids as well as "aqua materials", in which a tiny amount of additive renders water mechanically robust. From his personal insight he shares in this Interview, we can learn how his research evolved since his undergraduate studies. Moreover, he shares his vision on the importance of supramolecular polymers (Supra-Plastics) to realize a sustainable society.
Long lifetime generation IV image intensifiers with unfilmed microchannel plate (2000)

Current Generation II Gallium Arsenide (GaAs) image intensifier tube technology requires that the tube microchannel plate (MCP) component have a thin dielectric coating on the side facing the tube's photocathode component. This protective coating substantially reduces the release from the MCP of ions and neutral species, particularly when the image intensifier is operated. The prevention of MCP outgassing is necessary in order ot prevent the poisoning of the Cs:O surface on the GaAs photocathode. Many authors have experimented with omitting the MCP coating. Such experiments have consistently led to an intensifier with a significantly reduced lifetime, due to contamination of the Cs:O layer on the photocathode. Unfortunately the MCP film acts as a scattering cneter to electron transport within the intensifier and effectively reduces the photoelectron detection efficiency. Substantial enhancement of the image intensifier operating parameters is the motivation for the removal of the MCP film. Removal of the MCP film promises to simplify MCP fabrication and enhance the intensifier parameters related to Electro-Optical performance and image quality. This paper presents results showing for the first time that it is possible to fabricate a long lifetime image intensifier with a single unfilmed MCP and achieve improved imaging and performance characteristics.
Preparation and Melting of Scrap in Aluminum Recycling: A Review (2018)

This work provides an overview of the aluminum (Al) recycling process, from the scrap upgrading to the melting process. Innovations and new trends regarding the Al recycling technologies are highlighted. Aluminum recycling offers advantages in terms of environmental and economic benefits. The presence of deleterious impurities in recycled Al alloys is increasing and this is the main drawback if compared to primary alloys. The continuous growth of undesired elements can be mitigated by different technologies, preliminary operations and treatments, and by the optimization of the melting process. Downgrading and dilution are possible solutions to reduce the rate of impurities, but they are not sustainable if the final use of Al alloy continuously increases. The main objectives in the development of the Al recycling are shown and discussed. In particular, the evolution of preliminary treatments of the scrap, as sorting, comminution and de-coating, is reported and a review of the melting technologies is also presented. However, the choice of performing preliminary operations to the melting stage, thus improving the operating conditions during the furnace running, is a trade-off between costs and process efficiency.
Effects of Tool Geometry on Hardened Layer of Friction Stir Processed Cast Iron (2012)

The authors clarified that various cast irons can be hardened by friction stir processing (FSP) in a previous study. However, the high applied tool load was indispensable for obtaining the hardened layer. In this study, the effect of the tool geometry on the applied tool load was investigated for forming the hardened layer by the FSP with a lower applied tool load. As a result, the applied tool load could be reduced by 36% using a concave tool.
Method-Based Differences in the Automated Analysis of the Three-Dimensional Morphology of Trabecular Bone (1997)

The three-dimensional (3D) morphology of trabecular bone is frequently quantified using computer programs. However, there are no standardized implementations of morphology programs and many variations are possible. Even though programs may use the same basic method, results can be significantly different because of differences in implementation. Morphology data from different laboratories therefore may not be comparable. The method of directed secants, with parallel plate assumptions, is commonly used to quantify 3D morphology. We examined the effect of several variations in the implementation of this method on measurements of trabecular plate number (Tb.N), trabecular thickness, and trabecular spacing. Three-dimensional micromagnetic resonance images of 10 bovine trabecular bone specimens were analyzed using several variations of the directed secant method. An analysis of covariance with repeated measures suggested that variations in the algorithm used to count test line intersections, variations in the criteria used to classify a test coordinate as bone or marrow, and variations in the number of test grid rotations had significant effects on Tb.N (p < 0.0001). The largest difference in Tb.N (52%) was due to the method used to count test line intersections with the bone-marrow interface. Variations in the classification algorithm and variations in the number of test line grid rotations resulted in a 6% difference in Tb.N. The spacing of the test line grids did not affect Tb.N (p = 0.28), and all differences were independent of volume fraction (p = 0.67). These data show that there can be significant differences in trabecular bone morphology measurements due only to the method used for the measurements. To facilitate comparisons between laboratories, we have made validated computer programs to measure trabecular bone morphology available over the Internet.
Comparison of conventional subspace based DOA estimation algorithms with those employing property-restoral techniques: simulation and measurements (2002)

We compare the performance of conventional subspace-based direction-of-arrival (DOA) estimation techniques such as ESPRIT and MUSIC with the integrated approaches that combine the constant modulus algorithm with subspace-based techniques. Simulated and measured results are presented for a variety of signal conditions. The integrated approach was found to perform significantly better than the conventional ESPRIT approach. Also, multipath present in the channel significantly degrades the performance of the DOA estimation algorithms, and this has been confirmed by measurement and ray tracing simulation. This work has application to smart antennas and position location.
Evaluation of a P,N‐ligated iridium(I) catalyst in hydrogen isotope exchange reactions of aryl and heteroaryl compounds (2017)

We have developed a novel and efficient iridium-catalyzed hydrogen isotope exchange reaction method with secondary and tertiary sulfonamides at ambient temperatures. Furthermore N-oxides and phosphonamides have been successfully applied in hydrogen isotope exchange reactions with moderate to excellent deuterium introduction.
A fully implantable rodent neural stimulator (2012)

The ability to electrically stimulate neural and other excitable tissues in behaving experimental animals is invaluable for both the development of neural prostheses and basic neurological research. We developed a fully implantable neural stimulator that is able to deliver two channels of intra-cochlear electrical stimulation in the rat. It is powered via a novel omni-directional inductive link and includes an on-board microcontroller with integrated radio link, programmable current sources and switching circuitry to generate charge-balanced biphasic stimulation. We tested the implant in vivo and were able to elicit both neural and behavioural responses. The implants continued to function for up to five months in vivo. While targeted to cochlear stimulation, with appropriate electrode arrays the stimulator is well suited to stimulating other neurons within the peripheral or central nervous systems. Moreover, it includes significant on-board data acquisition and processing capabilities, which could potentially make it a useful platform for telemetry applications, where there is a need to chronically monitor physiological variables in unrestrained animals.
Supplementary Table 5 from Enhanced <i>GAB2</i> Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition (2023)

&lt;p&gt;MetaCore analysis results&lt;/p&gt;
Role of respiratory viral infections in the development of atopic conditions (2008)

Progress into understanding the relationship between respiratory viral infections and allergic airway disease is essential for development of treatments aimed at treating common risk factors mediating association but not cause. Recent findings may have begun to identify key pathways open to therapeutic intervention.
The amino acid sequence of toxin IV from the Androctonus australis scorpion: Differing effects of natural mutations in scorpion α‐toxins on their antigenic and toxic properties (1992)

The complete amino acid sequence (64 residues) of the AaH IV toxin from the scorpion Androctonus australis Hector was determined by automated Edman degradation and was compared with the sequences of other Androctonus toxins. AaH IV was also tested by radioimmunoassay for binding to antisera raised against other toxins of the same species. The results indicated that AaH IV shares some of the antigenic properties of AaH I and AaH III toxins, but does not cross-react with anti-AaH II antibodies. The structural basis for the observed antigenic relationships can be found in the high degree of homology displayed by AaH IV with regard to AaH I and III, the changes in amino acid residues equally affecting regions included or excluded from the main predicted antigenic sites of AaH IV. The lower biological potency of AaH IV is presumably the result of some of the sequence differences. In particular, substitution affecting the charge and bulkiness of residue 61 could account for the poor receptor binding and consequential weak toxic properties of this molecule.
Atmospheric pollution measurement by lidar (1991)

A review, with 12 refs., on the instrumentation for and principles of the differential absorption lidar technique.
Adenovirus 36 infection and obesity risk: current understanding and future therapeutic strategies (2022)

The role of Ad36 in the development of obesity has already been established. Future research should focus on the development of vaccines against this agent, drug discovery for infected individuals, and effective therapeutic uses of E4orf1 gene protein for diabetes and other diseases in clinical practice.
Inhibition of AP-1 by the Glucocorticoid-inducible Protein GILZ (2001)

The immunosuppressive effects of glucocorticoids arise largely by inhibition of cytokine gene expression, which has been ascribed to interference between the glucocorticoid receptor and transcription factors such as AP-1 and NF-kappa B as well as by competition for common coactivators. Here we show that glucocorticoid-induced inhibition of interleukin-2 mRNA expression in activated normal T cells required new protein synthesis, suggesting that this phenomenon is secondary to expression of glucocorticoid-regulated genes. One of the most prominent glucocorticoid-induced genes is glucocorticoid-induced leucine zipper (GILZ), which has been reported to inhibit activation-induced up-regulation of Fas ligand (FasL) mRNA. Indeed, transient expression of GILZ in Jurkat T cells blocked induction of a reporter construct driven by the FasL promoter. This could be accounted for by GILZ-mediated inhibition of Egr-2 and Egr-3, NFAT/AP-1-inducible transcription factors that bind a regulatory element in the FasL promoter and up-regulate FasL expression. GILZ also potently inhibited AP-1-driven and IL-2 promoter-driven reporter constructs, and recombinant GILZ specifically interacted with c-Fos and c-Jun in vitro and inhibited the binding of active AP-1 to its target DNA. Whereas homodimerization of GILZ required the presence of its leucine zipper, the interaction with c-Fos and c-Jun occurred through the N-terminal 60-amino acid region of GILZ. Thus, GILZ represents a glucocorticoid-induced gene product that can inhibit a variety of activation-induced events, at least in part by direct interference with AP-1, and is therefore a candidate for a mediator of glucocorticoid-induced immunosuppression.
Dendritic and Hyperbranched Polymers from Macromolecular Units: Elegant Approaches to the Synthesis of Functional Polymers (2011)

This perspective presents the state-of-the-art techniques to synthesize highly branched polymers such as dendrimers and hyperbranched polymers with well-defined linear chains between branch points. These highly branched polymers are essentially the long-chain analogues of conventional dendrimers and hyperbranched polymers and have been given many names, including dendrimer-like, DendriMac, HyperMac, etc. We cover the various synthetic strategies: the direction of synthesis (i.e., core outward or periphery inward) and the building of hyperbranched polymer either through iterative chain growth/branching reactions or from well-defined and reactive building blocks. The first section of this paper focuses on the iterative chain growth/branching reactions. These reactions have been used to create long-chain analogues of dendrimers. The second section highlights the modular synthesis of long-chain analogues of dendrimers following traditional dendrimer chemistry, based on divergent or convergent synthesis, and using linear polymers, or macromonomers, as building units. The third section outlines the modular synthesis of hyperbranched polymers via single step addition of macromonomers. The final section of this perspective highlights other related syntheses of long-chain hyperbranched polymers that do not fit within the groups described above.
Gingival Fluid and Serum in Periodontal Diseases: II. Evidence for Cleavage of Complement Components C3, C3 Proactivator (Factor B) and C4 in Gingival Fluid (1977)

1. C3 activation products C3c and C3d can be demonstrated in gingival pocket fluid from patients with severe periodontitis. 2. Quantitatively, C3d levels in GF are comparable to levels attained consequent to immune-complex and tryptic activation of human serum. 3. The alternate pathway of complement activation occurs in the periodontal pocket, as demonstrated by conversion of C3 proactivator (Factor B) to C3-activator Bb. 4. C4 is present in an altered form in some, but not all, GF's. This form is electrophoretically similar to that generated from serum by C1s and several proteolytic enzymes.
Identification of Metal–Organic Framework Materials for Adsorption Separation of Rare Gases: Applicability of Ideal Adsorbed Solution Theory (IAST) and Effects of Inaccessible Framework Regions (2012)

A collection of >3000 MOFs with experimentally confirmed structures were screened for performance in three binary separations: Ar/Kr, Kr/Xe, and Xe/Rn. 70 materials were selected for further analysis, and calculations were performed to account for inaccessible regions. Single component GCMC calculations were performed to parametrize IAST calculations on these 70 materials. An approach that avoids possible imprecision in IAST due to curve-fitting of single component isotherms is introduced. The precision of IAST for these gas pairs was confirmed with extensive binary GCMC calculations. For each binary separation, materials were identified with predicted performance that surpasses the state of the art. A significant number of materials were found to be “reverse selective” in the sense that a smaller gas species is preferably adsorbed over a larger species. The physical origin of this phenomenon is explained. The effect of temperature on separation performance was also examined.
Prevention of Urological Complications after Kidney Transplantation (1971)

WEIL, RICHARD III, M.D.; SIMMONS, RICHARD L. M.D.; TALLENT, MARION B. M.D.; LILLEHEI, RICHARD C. M.D.; KJELLSTRAND, CARL M. M.D.; NAJARIAN, JOHN S. M.D. Author Information
Painful Diabetic Peripheral Neuropathy (2007)

Painful peripheral neuropathy is a common complication of diabetes mellitus that can affect almost every tissue of the body. In the absence of a curative therapy for this disorder, pharmacologic or nonpharmacologic tools, or a combination of both, can be used to provide relief of symptoms. This article reviews medications currently used to manage painful diabetic neuropathy. The pathogenesis of painful diabetic neuropathy is described as a basis for understanding medication selection. The literature describing the pharmacologic properties of medications used to treat painful diabetic neuropathy is also reviewed. Comparisons of medication dosages, frequencies, and adverse effects are offered to help with selection of the most appropriate agent for each individual patient. (J Am Podiatr Med Assoc 97(5): 394–401, 2007)
A computationally efficient wavelet transform CELP coder (2002)

A wavelet-transform-based CELP coder design is presented in this paper for high-quality speech coding at about 4.8 kbits/s. The coder quantizes the second residual using a wavelet transform approach instead of the stochastic-codebook-based vector quantization normally used in CELP coders, including the U.S. Federal Standard FS 1016 coder at 4.8 kbits/s. The wavelet coder improves the computational efficiency for encoding the second residual by requiring only 1.2 MIPS instead of 8.3 MIPS required by FS 1016. Subjective speech quality tests involving pairwise comparisons show that the wavelet coder was preferred 61% of the time over FS 1016.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Sorting And Indexing With Partitioned B-Trees (2003)

Partitioning within a B-tree, based on an artificial leading key column and combined with online reorganization, can be exploited during external merge sort for accurate deep read-ahead and dynamic resource allocation, during index creation for a reduced delay until the first query can search the new index, during data loading for streaming integration of new data into a fully indexed database, and for miscellaneous other operations.
A Novel Receiver Aided Beamforming Technique (2006)

In this paper, we propose a new receiver-aided beamforming scheme to exploit the multiuser diversity in a multiantenna broadcast channel. By introducing an appropriately designed beamforming codebook that consists of the beam matrices, we can further exploit multiuser diversity by performing beam matrix selection operation and improve system throughput. The beam matrix selection could be implemented by the aid of receivers in practical system. Beamforming codebook is generated offline and stored at the base station (BS) and every user's receiver. Each user calculates the achievable signal to interference plus noise ratio (SINK) using the available channel state information at the receiver (CSIR), all beamforming matrices in the codebook and all beam vectors in the selected beam matrix, and then forms feedback information including the maximum sink and the corresponding best beam matrix index and beam vector index. Based on the feedback information, the BS runs scheduling algorithm to maximize throughput. Numerical results show that this scheme can considerably improve throughput of existed random beamforming scheme with only a few more bits feedback overhead.
Lithographic stochastics: beyond 3σ (2017)

As lithography tools continue their progress in both NA and wavelength in pursuit of Moore’s law, we have reached the point where the number of features printed in a single pass can now easily surpass 1 trillion. Statistically, then, one should not be surprised to see some members of such a population exhibit fluctuations as great as 7&sigma;. But what do these fluctuations look like? We consider the problem in terms of variations in the effective local resist sensitivity caused by feature-to-feature differences in absorbed photons and resist component counts. We model such variations as a normal distribution, rather than the CDs themselves. As the CD vs. Dose curve is generally nonlinear over large ranges, the normal distribution of the local effective sensitivity then maps to a non-normal distribution in CD. For the case of individual vias printed near the resolution limit, this results in many more such undersized or completely closed vias than one would expect from a normal distribution of the CDs. We show examples of this behavior from both EUV exposures in the fab, and ebeam exposures in the lab. For the latter, results from a simple resist with a somewhat low quencher loading produce approximately the CD variation one would expect by modeling the quencher as distributed normally in the resist.
Development and Validation of an Improved Inducer–Regulator Protein Complex in the pBRES-Regulated Expression System (2008)

Widespread adaptation of small molecule-regulated expression systems requires the development of selective inducer molecules that do not have any significant side effects on the endogenous receptors from which the regulated expression system is derived. Here we report the identification and in vitro validation of a novel inducer-receptor pair for the single-plasmid regulated expression system termed pBRES, which contains the ligand-binding domain from the human progesterone receptor (hPR). A small molecule inducer, BLX-913, has been identified as having a 30-fold lower IC(50) for the human progesterone receptor than mifepristone (MFP), the previously best characterized inducer for pBRES. Using modeling-guided protein engineering, compensatory mutations were installed at positions W755 and V729 (hPR numbering) in the ligand-binding pocket of the pBRES regulator protein (pBRES RP) to accommodate the new inducer and allow induction of transgene expression to levels previously seen with MFP. The improved inducer-pBRES RP complex was validated in vitro by monitoring the induction of luciferase, murine secreted alkaline phosphatase, and human interferon beta transgenes in mouse skeletal muscle cells. The engineered pBRES demonstrated low levels of transgene expression in the absence, and high expression levels in the presence, of the new BLX-913 inducer. Findings presented here allow induction of the pBRES-regulated gene expression system by a compound with markedly lower anti-hPR activity than MFP, the previously best characterized inducer.