gebhart/patrepeval huggingface dataset:
Combining two genetic sexing strains allows sorting of non-transgenic males for Aedes genetic control (2023)

Chemical control of disease vectoring mosquitoes Aedes albopictus and Aedes aegypti is costly, unsustainable, and increasingly ineffective due to the spread of insecticide resistance. The Sterile Insect Technique is a valuable alternative but is limited by slow, error-prone, and wasteful sex-separation methods. Here, we present four Genetic Sexing Strains (two for each Aedes species) based on fluorescence markers linked to the m and M sex loci, allowing for the isolation of transgenic males. Furthermore, we demonstrate how combining these sexing strains enables the production of non-transgenic males. In a mass-rearing facility, 100,000 first instar male larvae could be sorted in under 1.5 h with an estimated 0.01-0.1% female contamination on a single machine. Cost-efficiency analyses revealed that using these strains could result in important savings while setting up and running a mass-rearing facility. Altogether, these Genetic Sexing Strains should enable a major upscaling in control programmes against these important vectors.
Applications of symbolic dynamics to differential chaos shift keying (2002)

In this paper, we present an enhanced version of the differential chaos shift keying (DCSK) scheme where the carrier symbolic dynamics are exploited for conveying useful information. This is achieved by means of a pseudochaotic encoder which spreads the input sequence approximating the dynamics of the Bernoulli shift. The information encoded in the pseudochaotic carrier is retrieved by using standard maximum-likelihood detection techniques. Moreover, it is shown that the proposed method can also be useful for noise filtering purposes. Finally, we characterize the total transfer of information between transmitter and receiver in terms of trans-information.
Sink or Swim? A Case Study Approach to Teaching Information Evaluation (2019)

Teaching evaluation skills in the highly emotional world of fake news is a daunting task. This interactive presentation will showcase a unique and engaging evaluation lesson designed by a team of librarians at Utah State University. The lesson uses realistic case studies to give students the critical distance necessary to practice evaluation before diving into their personal research and biases. Attendees will have the opportunity to experience a simulation of the lesson’s case study activity and discuss strategies for teaching students adaptable evaluation skills that they can apply in their academic, professional, and personal lives.
A human laterality disorder caused by a homozygous deleterious mutation in MMP21 (2015)

Our data implicate loss of MMP21 as a cause of heterotaxy in humans with concomitant defects in Notch signaling. In support of this finding, a homozygous missense mutation in MMP21 was identified previously in mice with N-Ethyl-N-Nitrosourea (ENU)-induced heterotaxy. Taken together, these observations suggest a role of matrix metalloproteinases in the establishment of asymmetric organ development, likely through the regulation of morphogenetic signals.
Avoidance of moving obstacles through behavior fusion and motion prediction (2002)

We propose a novel approach of fusing the fuzzy control actions of the obstacle avoidance, goal seeking and steering behaviors, in which the steering behavior is derived from motion prediction. As such, the navigator is more capable to steer clear of the zone of high collision probability. Through simulation, it has been confirmed that the navigator having this steering behavior can tackle multiple moving obstacles successfully at much higher speed compared with those without. Furthermore, it does not require any a priori knowledge of the obstacle motion.
Supplementary material for nonparameteric adaptive control of time varying systems using gaussian processes (2013)

This technical report has supplementary material for "Bayesian Nonparametric Adaptive Control of Time-varying Systems using Gaussian Processes" American Control Conference paper
Combined tendon vibration and virtual reality for post-stroke hand rehabilitation (2013)

Sensory function is essential for functional post-stroke recovery and control of basic hand movements like grasping. Despite this fact, therapy focuses strongly on motor aspects of rehabilitation, requiring active participation and thus excluding stroke patients with severe paresis. The aim of our novel therapeutic approach combining virtual reality, based on clinically proven mirror therapy, and tendon vibration of hand and wrist muscles is to induce neuroplastic changes leading to improved hand function. This paper presents the further development and evaluation of a robotic device, which can apply vibrations at precise locations on the finger flexor tendons to create illusions of extension movements and visualize the movements with a virtual hand. A preliminary study including 16 healthy subjects investigated the influence of the virtual reality on the perception of proprioceptive illusory movements. The experimental results provided evidence that the addition of the virtual reality enhanced the perception of the illusory movement generated by tendon vibration, by inducing movements with significantly higher extension (+4.5%, p <; 0.05). Furthermore, the virtual reality allowed a better controlled temporal elicitation of the illusion. These findings indicate the potential of this novel strategy for a more effective therapy, especially for severely impaired patients.
Stimulation of Inositol Phospholipid Hydrolysis by Excitatory Amino Acids Is Enhanced in Brain Slices from Vulnerable Regions after Transient Global Ischemia (1989)

Stimulation of inositol phospholipid hydrolysis by transmitter receptor agonists was measured in slices from hippocampus, cerebral cortex, and corpus striatum at various intervals after transient global ischemia in rats. Ischemia was induced through the four-vessel occlusion model. Stimulation of [3H]inositol monophosphate formation by excitatory amino acids was greatly enhanced in hippocampal slices prepared from ischemic rats at 24 h or 7 days after reperfusion. This potentiation was more evident using ibotenic acid and was also observed in cerebral cortex, but not in corpus striatum. This regional profile correlated with the pattern of ischemia-induced neuronal damage observed under our experimental conditions. The enhanced responsiveness to excitatory amino acids was always accompanied by an increase in both basal and norepinephrine-stimulated [3H]inositol monophosphate formation. In contrast, stimulation of [3H]inositol monophosphate formation by carbamylcholine was not modified in hippocampal or cortical slices from ischemic animals.
Fast Graph-Search Algorithms for General-Aviation Flight Trajectory Generation (2005)

We consider numerical algorithms for on-board flight trajectory generation and optimization in three dimensional space. Our approach relies on graph search algorithms, which perform a global search over the set of feasible trajectories. We start by formulating a simplified kinematic model that is appropriate for General Aviation aircraft. The cost function to be optimized includes, the cost function to be optimized accounts for position-dependent criteria such as the flight altitude and terrain clearance. Additional “dynamic” components that involve the angular velocities are introduced to account for riding qualities and pilot workload. Using an approximate grid-based discretization scheme, we transform the continuous optimization problem into a search problem over a finite graph, and apply Dijkstra’s shortest-path algorithm to this problem. To reduce the computation time to acceptable levels, we introduce a novel state reduction technique that leads to sub-optimal search. Further speedup is achieved by heuristic search techniques and hierarchical methods. Performance of the proposed algorithms is evaluated for a trajectory optimization problem with terrain following over a 100 × 100 kilometer area. Our experiments demonstrate the potential of these algorithms, when combined, to provide an on-board solution to realistic flight trajectory generation problems. ∗Graduate student, Department of Electrical Engineering, Technion—Israel Institute of Technology, Haifa, Israel †Department of Aeronautical Engineering, Technion—Israel Institute of Technology, Haifa, Israel ‡Department of Electrical Engineering, Technion—Israel Institute of Technology, Haifa, Israel
Capabilities of Oat Extracts in Inhibiting Cholesterol and Long Chain Fatty Acid Oxidation During Heating (2006)

ABSTRACT The antioxidant activities of oat groat extracts using different solvents were investigated. For acetone, hexane, and methanol extracts, the total phenolic compound contents were 12.83, 8.56, and 26.17 μg of catechin equivalent/g, respectively. Their corresponding free radical scavenging activities measured using the DPPH (2,2'‐diphenyl‐1‐picrylhydrazyl) method were 0.68, 0.35, and 0.79 μmol of Trolox equivalent/g, respectively. All oat extracts presented significantly greater capability in preventing cholesterol oxidation than the control (no extract added) during heating at the three levels of addition (1, 5, and 10 mg). The capability of the hexane or acetone extract in preventing cholesterol oxidation was not as effective as the methanol extract. In the docosahexaenoic acid (DHA, C22:6) oxidation test, all oat extracts at the level of 5 and 10 mg had greater inhibition capability on DHA oxidation than the control (DHA only). No significant inhibition was found for the hexane and acetone extract at the level of 1 mg, except for the methanol extract. The capabilities of oat extracts to inhibit oxidation of cholesterol and DHA from high to low was methanol, acetone, and hexane extract, which agreed with their free radical scavenging activities and total phenolic compound contents.
Ketorolac attenuates the blood pressure response to dynamic exercise in peripheral arterial disease patients (1165.5) (2014)

Humans with peripheral arterial disease (PAD) have an augmented exercise pressor reflex (EPR) but the metabolites responsible for this augmented response are unknown. We tested the hypothesis that intravenous infusion of ketorolac (a COX inhibitor) would attenuate the rise in mean arterial blood pressure (MAP) and heart rate (HR) in response to low‐intensity plantar flexion exercise in humans with PAD. Six PAD patients underwent four minutes of one‐legged rhythmic plantar flexion (30 contractions/min) in the supine posture. The workload began at 0.5 kg and progressed by 0.5 kg each minute. MAP and HR were measured on a beat‐by‐beat basis; changes from baseline in response to exercise were determined for both control and ketorolac conditions. Ketorolac did not affect resting MAP (97 ± 3 versus 94 ± 4 mmHg) or HR (58 ± 2 versus 55 ± 2 bpm). During the first 20 seconds of exercise with the most diseased leg, ΔMAP was significantly attenuated with ketorolac (2 ± 2 mmHg) as compared to control (8 ± 2 mmHg) but ΔHR was similar (7 ± 2 versus 6 ± 1 bpm). During the second and third minutes of exercise, ΔMAP was also significantly attenuated under ketorolac. These data indicate that prostaglandins contribute to the augmented EPR in patients with PAD. Because this response occurred at very low workloads, we speculate that muscle mechanoreceptors are sensitized by cycolooxyegnase products under conditions of chronic limb ischemia. Grant Funding Source : Supported by NIH P01 HL096570 (LIS) and UL1 TR000127 (LIS)
Simplified modified Rankin Scale questionnaire correlates with stroke severity (2013)

The good correlation of the smRSq with the initial stroke severity further confirms the smRSq validity in assessing functional outcome after stroke.
Innovative approach for the synthesis of N-substituted amides from nitriles and alcohols using propylphosphonic anhydride (T3P®) under solvent-free conditions (2019)

Novel and convenient methodology for the construction of N-substituted amide derivatives have been developed from nitriles and alcohols using propylphosphonic anhydride (T3P®). This methodology is an alternate approach to the synthesis of amides via Ritter reaction, which is one of the classical methods for the synthesis of N-substituted amides from nitriles and alcohols. In this approach, first T3P® activates the alcohol which is then attacked by nitrile to form N-substituted amides. This methodology can also apply for the synthesis of benzhydryl ether. This developed protocol is one of the novel applications of T3P®.
A mathematical model for initial design iterations and feasibility studies of oxygen membrane reactors by minimizing Gibbs free energy (2023)

Ceramic Membrane Reactors offer an opportunity towards the transition to renewable energies and defossilized economies by efficiently coupling chemical reactions and heat utilization. To identify viable processes, mathematical models are needed that allow a straightforward assessment. In this study, a generalized model is presented that can be applied to membrane reactor concepts using a mixed oxygen transport membrane. The model assumes chemical equilibrium which is realized by minimizing the Gibbs free energy in the individual reaction chambers. Both reaction chambers are coupled by the Wagner equation to account for the oxygen ion flux through the membrane. Experimental data from the literature were used to validate the model for water splitting, partial oxidation of methane, and the coupling of these two processes. The model allows to investigate various process parameters such as oxygen flux and gas compositions, making the model particularly suitable for feasibility studies and initial design iterations for new reactor developments.
Rational Design of a Solvatochromic Fluorescent Uracil Analogue with a Dual‐Band Ratiometric Response Based on 3‐Hydroxychromone (2014)

Fluorescent nucleoside analogues with strong and informative responses to their local environment are in urgent need for DNA research. In this work, the design, synthesis and investigation of a new solvatochromic ratiometric fluorophore compiled from 3-hydroxychromones (3HCs) and uracil fragments are reported. 3HC dyes are a class of multi-parametric, environment-sensitive fluorophores providing a ratiometric response due to the presence of two well-resolved bands in their emission spectra. The synthesized conjugate demonstrates not only the preservation but also the improvement of these properties. The absorption and fluorescence spectra are shifted to longer wavelengths together with an increase of brightness. Moreover, the two fluorescence bands are better resolved and provide ratiometric responses across a broader range of solvent polarities. To understand the photophysical properties of this new fluorophore, a series of model compounds were synthesized and comparatively investigated. The obtained data indicate that uracil and 3HC fragments of this derivative are coupled into an electronic conjugated system, which on excitation attains strong charge-transfer character. The developed fluorophore is a prospective label for nucleic acids. Abstract in Ukrainian: .
Biomonitoring exposure to metal compounds with carcinogenic properties. (1993)

Several metals such as arsenic, beryllium, chromium and nickel are carcinogenic to man when they occur in certain well-defined physicochemical forms. The carcinogenic potential of these metals is linked to their mutagenic properties. The determination of the metal or possibly of its metabolites in biological media and the cytogenetic examination of somatic cells are two methods that can currently be used to monitor exposure of populations at risk. Due to the use of inappropriate methodology, the value of the positive cytogenetic results published so far appears questionable. By contrast, the concentrations of metals in blood, urine, or other biological materials can be determined with accurate and precise methods. Although it does not permit a direct assessment of the carcinogenic risk, this approach is currently the most suitable for monitoring exposed populations.
Abstract 4 (2014)

AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK
Sulfoxide-Directed Intramolecular [4 + 2] Cycloadditions between 2-Sulfinyl Butadienes and Unactivated Alkynes (2010)

Sulfinyl dienynes undergo thermal and catalyzed IMDA cycloadditions, often at room temperature, to produce cyclohexa-1,4-dienes with good yields and high selectivities. Additionally, the products preserve a synthetically useful vinyl sulfoxide functionality. The selective manipulation of the double bonds in the cycloadducts has also been examined in this work.
Design of multipinhole collimators for small animal SPECT (2004)

High resolution single photon emission computed tomography (SPECT) of small animals with pinhole collimators is hampered by poor sensitivity. For the target application of imaging the brain of an unanesthetized, unrestrained mouse, the design of multipinhole collimators for small, compact gamma cameras was studied using numerical simulations. The collimators were designed to image the mouse at different axial positions inside a tube aligned with the axis of rotation (AOR) of the SPECT system. The proposed system consisted of a 10 cm/spl times/20 cm pixelated detector with 2 cm from the AOR to the collimator mask and a focal length of 7 cm for a magnification of 3.5 on the AOR. A digital mouse phantom was created with a brain:background activity concentration ratio of 8:1. The brain region contained small disks and hot and cool cylinders for contrast and signal-to-noise ratio (SNR) quantitation. SPECT projection data were simulated at 120 angles for four pinhole masks having 1, 5 and two arrangements of 13 pinholes. Projections were scaled to model a 30 min study with doses of 0.3, 1 and 3 mCi in the mouse. Images were reconstructed with an iterative ordered subset expectation maximization (OSEM) algorithm. The peak SNR improved with multipinhole collimation compared with single pinhole imaging when there was no increased activity in the liver or bladder. With such activity, peak SNR was about the same for all collimators. For all cases peak SNR occurred at higher contrast values with multipinhole collimation. The extended axial range of multipinhole arrays enabled the mouse brain to be imaged with decreased axial blurring when the mouse was translated axially. These results suggest that mouse brains can be successfully imaged at realistic activity levels with multipinhole arrays and projection data multiplexing.
cDNA microarray analysis in multiple sclerosis lesions: detection of genes associated with disease activity (2003)

cDNA microarray analysis of the regions of pathologically proven different activity of multiple sclerosis lesions was performed. Major differences in gene expression (DGE) occurred between the lesion margin and lesion centre in active lesions studied (57 and 69 genes differentially expressed, respectively), whereas the margins and centres of silent lesions showed markedly reduced heterogeneity (only 11 and two genes differentially expressed, respectively). To compare differences between chronic active and silent lesions, we performed DGE comparison of the pooled data from both types of lesions. The major DGE occurred at the lesion margin, 156 (26; 5%), the greater number representing upregulated genes at the margin of active lesions (15%). Fourteen genes were found to be significantly upregulated in marginal versus central zones in active lesions examined. These genes comprised predominantly inflammation/immune-related factors. We also performed DGE analysis of pooled genes upregulated at the margin of active lesions and found that among the 50 genes showing differences, nine out of 14 were identified in the previous analysis of overlapping differentially expressed genes. Thus this microarray analysis has identified a novel set of genes associated with lesion activity in multiple sclerosis, many of them not previously linked with the disease.
ChemInform Abstract: Versatile Synthesis of Dialkyl Cyclopropylphosphonates via Reductive Phosphonation. (1986)

Abstract Treatment of the gem‐dibromocyclopropanes (I) with trialkyl phosphite in the presence of triethylamine and water at 90°C gave mixtures of cis‐ and trans‐ (II).
Soccer Replay Detection using Scene Transition Structure Analysis (2006)

Replay scene detection is a useful technique for content based sports video analysis. Most current researchers try to find suitable visual and/or compressed domain features to detect the replay scene from a broadcast video. We present a novel approach using context information from the concurrence of replay and other types of shots to detect the replay scenes. We first perform a shot classification and then a scene transition structure analysis on the generated shot label sequence to extract the replay scene. The proposed model is computationally fast and some promising results were obtained.
Development of a Process Simulation Program (ORBIC-1) for a Building Construction Robotics System (1988)

Development of a Process Simulation Program (ORBIC-1) for a Building Construction Robotics System A. Sakaguchi, T. Shiokawa, K. Hamada, Y. Yamawaki, K. Izumi, T. Wakisaka Pages 669-678 (1988 Proceedings of the 5th ISARC, Tokyo, Japan, ISSN 2413-5844) Abstract: A construction process simulation program which is called ORBIC-1, is developed. ORBIC-1 consists of Building Model Data Generation, Construction Process Simulation of Conglomerate Robots, Simulation Result Graphic Display and Simulation Result Analysis subsystems. The results of the simulation process are displayed in 3-D color animation graphics and also analyzed from a construction schematic point of view, and several kinds of plotter drawings of the construction schedule charts are produced. Keywords: No keywords DOI: https://doi.org/10.22260/ISARC1988/0075 Download fulltext Download BibTex Download Endnote (RIS) TeX Import to Mendeley
A GTO DC Circuit Breaker Controlled by a Single-Chip Microcomputer (1985)

Power semiconductor circuit-breaker application suggests the need for microcomputers that provide firing control, excellent dc short-circuit fault interrupting performance, precise overload protection of themselves, as well as high reliability with minimum components. This paper deals with the prototype dc 1500 V GTO (gate turnoff thyristor) circuit breaker controlled by a single-chip microcomputer. Emphasis is on the GTO junction temperature observation.
Economical heat recovery dynamic control and business model for supermarket refrigeration system coupled with district heating system (2022)

Large amounts of waste heat during the cooling process of supermarket refrigeration systems (SRS) would be released. A heat recovery strategy potentially contributes to reducing the supermarket’s heating costs related to buying heat from a district heating system (DHS). This paper explores the techno-economic feasibility of heat recovery for a real SRS integrated with a heat recovery unit (HRU) in terms of designing a dynamic heat recovery control (HRC) and business models. A cost-effective HRC is firstly developed for HRU to optimally manipulate the amount of heat recovered, thereby minimizing the real-time heat recovery cost. Furthermore, the business models of heat recovery under a long-term operation are proposed based on two transactional strategies between the SRS and DHS. A field test of the dynamic heat recovery for a remote SRS in Copenhagen Nordhavn area is conducted which demonstrates the proposed HRC algorithm can have a benefit of 0.49€ from a 3-h heat recovery operation. Moreover, the one-year operation of the SRS is also simulated which proves the developed two business models of heat recovery can achieve significant savings of 93% and 41% in energy costs.