gebhart/patrepeval huggingface dataset:
Not worth the risk (2007)

In Brief Leftover medications…eye-ear administration mix-ups…dangerous luer design…beware of these soundalike neuro drugs
One-on-One in a World of Twenty-Four (2018)

As a long-time tutor, I was startled by the lack of individual time I got with my students as I took on the more powerful role of Graduate Instructor. I fear that I lose a lot of my effectiveness due to no longer being a peer to English 1010 students. I explore why that is and potential ways to fight back against lost face-time in what ways I can.
Charge-Conversional and pH-Sensitive PEGylated Polymeric Micelles as Efficient Nanocarriers for Drug Delivery (2014)

A novel amphiphilic copolymer, poly (ethylene glycol)-graft-polyethyleneimine/amide (PEG-g-PEI/amide), is synthesized by grafting PEG and1,2-cis-Cyclohexanedicarboxylic anhydride onto the PEI. PEGylated polymeric micelles can be assembled from the amphiphilic copolymers with well-defined nano-sizes, and anti-cancer drugs are successfully loaded into micelle core formed by the amide. The amides with neighboring carboxylic acid groups exhibit pH-dependent hydrolysis and can reversibly shield the cationic charge of amine groups on the PEI, giving the micelles a charge-conversion property from negative to positive in acidic tumor tissue environment. Meanwhile, the cleavage of amide bonds at acidic pH also results in the disassembly of the micelle and pH-responsive drug release. These micelles are promising drug delivery systems due to their smart properties: PEGylation, suitable size, charge-conversion, and simultaneous pH-sensitive drug release.
Supplementary Table S1 from Survivin Autoantibodies Are Not Elevated in Lung Cancer When Assayed Controlling for Specificity and Smoking Status (2023)

&lt;p&gt;Supplementary Table S1. Characteristics of NSCLC cases, smoking-habit controls and non-smoking controls.&lt;/p&gt;
Pilling properties of wool single jersey made of compact and conventional ring yarns after anti-felting treatment (2013)

This work studied the differences between wool single jersey made from compact and conventional ring-spun yarns composed of surface-modified fibers with different anti-felting treatments. Wool yarns (100%), produced from the fibers modified by two commercial chemical treatments, Basolan®88 and Kroy-resin, were spun according to compact and conventional ring-spinning systems in two different twist factors of spun yarn. The surface morphology and physical properties of wool fibers and conventional and compact ring yarns and the pilling properties of these fabrics were examined and compared with each other before and after the chemical treatment. The breaking strength of modified fibers decreased if compared with the control. Results indicated that the surface morphology of wool fiber changed by Basolan®88 and Kroy-resin treatment, and a lower friction coefficient increased with the differential frictional effect value. The hairiness index ( S 3 ) of compact yarn was a reduction by 60% and the strength and elongation percentages were higher compared with conventional ring yarn. The fiber packing density of compact yarn was 30% higher from the fiber distribution pattern in the yarn cross-section. Another important finding was that the fabric produced with compact yarn showed better anti-pilling property and more mass loss.
Detection and Identification of Mycobacterium tuberculosis Directly from Sputum Sediments by Ligase Chain Reaction (1998)

Sputum specimens received for the diagnosis of tuberculosis or other mycobacterial infections were tested by a ligase chain reaction (LCR)-based assay and acid-fast stain and culture techniques. Results from the LCR assay (Abbott LCx Mycobacterium tuberculosis [MTB] Assay) were compared to results from standard culture techniques held for 6 weeks. Four hundred ninety-three specimens from 205 patients suspected of pulmonary tuberculosis were included in the prospective study. Thirty-four (6.9%) of the specimens were culture positive for M. tuberculosis, and 13 (38%) of these were also fluorochrome stain positive. LCR sensitivities and specificities compared to culture were 74 and 98%, respectively. LCR sensitivity was 100% for fluorochrome stain-positive specimens and 57% for fluorochrome stain-negative specimens. Nine LCR-negative, culture-positive specimens were the result of low concentrations of M. tuberculosis. No inhibitors were detected in any of these specimens. Of the eight LCR-positive, culture-negative specimens, five were from patients with active tuberculosis. With these considered culture misses, final LCR sensitivity, specificity, positive predictive value, and negative predictive value were 77, 99, 91, and 98%, respectively. The same performance values for the fluorochrome acid-fast bacillus smear were 33, 98, 62, and 94%, respectively. After normal laboratory sputum processing, the Abbott LCx MTB Assay can be completed in 6 h. Thus, it is possible to have results available within 8 h of specimen submission.
Thermal conduction from microcantilever heaters in partial vacuum (2007)

This paper reports the thermal and electrical characteristics of a heated microcantilever in air and helium over a wide range of pressures. The cantilever heater size modulates thermal conductance between the cantilever and its gaseous surroundings; and the Knudsen number, Kn characterizes this thermal conductance. When Kn&amp;lt;1, thermal transport from the cantilever heater depends on gas pressure, and when Kn&amp;gt;1, thermal transport from the cantilever heater remains constant. This measurement of thermal conductance around Kn=1 could aid the design and analysis of Pirani sensors and other microscale thermal sensors and actuators.
Metalorganic Vapor Phase Epitaxy of CuAlxGa1-x(SySe1-y)2 (1993)

Epitaxial layers of the CuAl x Ga 1- x (S y Se 1- y ) 2 quaternary ( x =0) and pentanary ( x ≠0) alloys lattice-matched to GaP substrates have been successfully grown by metalorganic vapor phase epitaxy using cyclopentadienyl-triethylphosphine-copper, triethylaluminum, triethylgallium, ditertiarybutylsulfide and diethylselenide as source materials. This pentanary alloy is the first ever grown to the best of our knowledge. Single and double heterostructures consisting of the quaternary and pentanary alloys have also been fabricated for the first time. A sample of the single heterostructure has shown stimulated emission at 77 K under pulsed light excitation.
A limit function for long-range ferromagnetic and antiferromagnetic superexchange (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA limit function for long-range ferromagnetic and antiferromagnetic superexchangeR. E. Coffman and G. R. BuettnerCite this: J. Phys. Chem. 1979, 83, 18, 2387–2392Publication Date (Print):September 1, 1979Publication History Published online1 May 2002Published inissue 1 September 1979https://pubs.acs.org/doi/10.1021/j100481a017https://doi.org/10.1021/j100481a017research-articleACS PublicationsRequest reuse permissionsArticle Views509Altmetric-Citations147LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Medical Uses of Fluorescence Imaging: Bringing Disease to Light (2011)

Fluorescence imaging is becoming an important diagnostic method in medicine. Advances in the quantum yields and properties of fluorophores combined with better biologic targeting make fluorescence imaging attractive. The lack of ionizing radiation, the lower costs, and the portability of optical imaging are additional advantages. Traditional fluorescence imaging probes are “always on” and require rapid biologic clearance of the unbound probe to achieve adequate target-to-background ratios. More advanced fluorescence imaging probes are “activatable,” meaning that they become fluorescent only under particular circumstances, such as after binding to the cell. This creates opportunities for very high target-to-background ratios, thus dramatically increasing sensitivity. When fluorescent probes also cause phototoxicity, they become both therapeutic and diagnostic (theranostic) agents and enable a “see and treat” paradigms. Here, we discuss the evolution of novel diagnostic probes in our laboratory ending with the development of targeted theranostic probes.
On matroid separations of graphs (1987)

Abstract Let K be a connected and undirected graph, and M be the polygon matroid of K . Assume that, for some k ⩾ 1, the matroid M is k ‐separable and k ‐connected according to the matroid separability and connectivity definitions of W. T. Tutte. In this paper we classify the matroid k ‐separations of M in terms of subgraphs of K .
MDM2 is recognized as tumor associated antigen (TAA) in B-CLL by CD8+ autologous T lymphocytes (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

5146 

BACKGROUND: The human homolog of the murine double-minute 2 oncoprotein, MDM2, is an attractive candidate target for a general TAA. MDM2 was shown to be overexpressed in CLL cells compared to normal B lymphocytes on the protein level as well as on the mRNA level. Therefore MDM2 might serve as potential tumor associated antigen (TAA) in CLL enabling expansion of MDM2-specific T cells. Methods: Unpulsed native CLL cells and CD40 ligand (CD40L)-stimulated CLL cells as antigen presenting cells (APC) were used to expand autologous T cells from 12 patients. RESULTS: In 11/13 CLL samples expression of MDM2 by real-time RT-PCR was detectable in contrast to normal B lymphocytes. The number of T cells during four weeks of in vitro culture increased 2-fold with native CLL cells as APC and 3.5-fold with CD40L-stimulated CLL cells as APC. Up to 32.3% of CD8+ T cells recognized specifically an MDM2-derived peptide bound to HLA-A2-dimers after 4 weeks of in vitro culture. The expanded T cells were also able to secrete IFN-γ upon recognition of the antigen demonstrated by IFN-γ-ELISPOT assays. T cells not only recognized an HLA-A2 binding MDM2 peptide presented by TAP-deficient T2 cells, but also MDM2 overexpressing autologous CLL cells in an HLA-A2 restricted manner. Nor HLA-A2 negative CLL cells, neither non-malignant cells, i.e. PBMC from healthy donors or tonsilar B cells were specifically recognized. CONCLUSION: MDM2 was shown for the first time to be naturally processed and presented as TAA in primary CLL cells enabling the expansion of functional autologous tumor-specific T cells which might be applicable in clinical vaccination trials or as a tool for a CLL-specific immune monitoring in the context of vaccination approaches including CD40L-gene modified autologous leukemic cells.
Prefetching with Helper Threads for Loosely Coupled Multiprocessor Systems (2008)

This paper presents a helper thread prefetching scheme that is designed to work on loosely coupled processors, such as in a standard chip multiprocessor (CMP) system or an intelligent memory system. Loosely coupled processors have an advantage in that resources such as processor and L1 cache resources are not contended by the application and helper threads, hence preserving the speed of the application. However, interprocessor communication is expensive in such a system. We present techniques to alleviate this. Our approach exploits large loop-based code regions and is based on a new synchronization mechanism between the application and helper threads. This mechanism precisely controls how far ahead the execution of the helper thread can be with respect to the application thread. We found that this is important in ensuring prefetching timeliness and avoiding cache pollution. To demonstrate that prefetching in a loosely coupled system can be done effectively, we evaluate our prefetching by simulating a standard unmodified CMP system and an intelligent memory system where a simple processor in memory executes the helper thread. Evaluating our scheme with nine memory-intensive applications with the memory processor in DRAM achieves an average speedup of 1.25. Moreover, our scheme works well in combination with a conventional processor-side sequential L1 prefetcher, resulting in an average speedup of 1.31. In a standard CMP, the scheme achieves an average speedup of 1.33. Using a real CMP system with a shared L2 cache between two cores, our helper thread prefetching plus hardware L2 prefetching achieves an average speedup of 1.15 over the hardware L2 prefetching for the subset of applications with high L2 cache misses per cycle.
Effect of Boron Addition on Creep Strength in 9Cr-3W-3Co-V-Nb Steels (2007)

Recently, boron is being added to high-strength steels for boilers and turbines in order to raise creep strength. However, there are various points that are not yet fully understood with regard to the creep-strengthening mechanism of boron addition. In order to investigate the influence of boron addition on creep strength, varying the amounts of boron and nitrogen were added in 9Cr-3W-3Co-V-Nb steels tempered two different conditions and investigated. Although creep strengths of all materials converged to become similar in the low-stress region, the materials tempering at 780°C with boron addition which exhibited the lowest strength on the high-stress region is seen to have slightly greater strength on the low-stress region. In analysis of the precipitates and grain boundary of creepruptured material conducted using TEM-EDS and Auger diffraction analysis equipment, the presence of boron could not be detected.
Myocyte enhancer factor 2C upregulates MASH‐1 expression and induces neurogenesis in P19 cells (2000)

MEF2C is a transcription factor expressed in neural lineages. After transient transfection, the MEF2 family of factors can act synergistically with the neural-specific transcription factor, MASH-1, and activate exogenous neural-specific promoters. To determine whether MEF2C is capable of modulating endogenous gene expression, P19 cell lines were analyzed that overexpressed MEF2C, termed P19[MEF2C] cells. Here we show that P19[MEF2C] cells differentiate into neurons when aggregated with ME(2)SO. MEF2C-induced neurons expressed neurofilament protein, the nuclear antigen NeuN, as well as MASH-1. Our results indicate that MEF2C can directly or indirectly activate the expression of MASH-1, leading to neurogenesis.
Engineering self-efficacy of women engineering students at urban vs. Rural universities (2011)

For more than two decades researchers have addressed gender issues in engineering. Efforts such as Engineer Girl (www.engineergirl.org), a website dedicated to increasing young girls' interest in pursuing an engineering degree, address the engineering "diversity gap". Potential improvements exist for increasing the number of women pursuing engineering careers, such as increasing their engineering self-efficacy. Engineering self-efficacy refers to a person's belief that he or she can successfully navigate the engineering curriculum and eventually become a practicing engineer. It encompasses self-efficacy, feeling of inclusion, and outcome expectations. A longitudinal multi-institutional study conducted by Marra and Bogue indicated statistically significant differences for female engineering students with respect to the coping, mathematics, and self-efficacy subscales. The authors wish to explore whether institutional setting (urban vs. rural) accounts for differences in female students' engineering self-efficacy.
Handwritten digit recognition by adaptive-subspace self-organizing map (ASSOM) (1999)

The adaptive-subspace self-organizing map (ASSOM) proposed by Kohonen is a recent development in self-organizing map (SOM) computation. In this paper, we propose a method to realize ASSOM using a neural learning algorithm in nonlinear autoencoder networks. Our method has the advantage of numerical stability. We have applied our ASSOM model to build a modular classification system for handwritten digit recognition. Ten ASSOM modules are used to capture different features in the ten classes of digits. When a test digit is presented to all the modules, each module provides a reconstructed pattern and the system outputs a class label by comparing the ten reconstruction errors. Our experiments show promising results. For relatively small size modules, the classification accuracy reaches 99.3% on the training set and over 97% on the testing set.
On Mercury(I) Oxo Compounds — Quasi‐Relativistic Computational and Experimental Studies (2003)

Abstract About 60 molecular species composed of up to 10 mercury atoms and of oxygen atoms and/or of some other elements or groups (such as halogen, OH 2 , OH, H, alkali, NO 3 ) have been investigated quantum chemically. Different density functional approaches and the ab initio SCF‐MP2 method were applied, comparing different basis sets and different atomic core sizes. It is important not to treat the Hg 5s, p, d as inactive core shells, and to use sufficiently many polarization functions. The shape of the 〉O‐Hg‐Hg‐O〈 units is not favorable concerning the formation of lattices composed of Hg I , O and OH only. Despite its bulkiness, the OHgHgO units can easily come into contact with each other and then disproportionate. This is prevented in the so‐called ternary M‐Hg I oxides by the embedded oxometallate (oxoacidic) anions. Furthermore, the Hg I and Hg II oxide bond energies are less favorable towards the stability of Hg I oxo compounds, as compared to Hg halidic or oxoacidic compounds. Both points are not promising concerning the search for Hg I oxides/hydroxides, although the preparation of such compounds, including spacer groups, by topochemical reactions can still not be excluded. So far, experimental efforts towards the synthesis of such a new class of compounds have only demonstrated that Hg II is strictly preferred over Hg I in the formation of solids of binary Hg‐O or ternary A‐Hg‐O composition (A = electropositive metal such as alkali, in contrast to M = transition or semi‐metal). This is so even if compounds containing ‘electron rich Hg δ— atoms’ (i.e. A‐Hg amalgams) are oxidized under mild conditions.
Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease (2023)

These data suggest that female microglia adopt disease-associated and senescent phenotypes in the aging mouse hippocampus, even in the absence of disease pathology, to a greater extent than males. This sexually divergent microglial phenotype may explain the difference in susceptibility and disease progression in the case of AD pathology. Future studies will need to explore sex differences in microglial heterogeneity in response to AD pathology and determine how sex-specific regulators (i.e., sex chromosomal or hormonal) elicit these sex effects.
Synthesis of Novel Annulated Hymenialdisine Analogues via Palladium-Catalyzed Cross-Coupling Reactions with Aryl Boronic Acids (2009)

Palladium-catalyzed Suzuki cross-coupling reactions of an indole vinyl triflate provides an efficient pathway for the synthesis of a diverse class of novel hymenialdisine analogues.
Advances in ECC Research (2002)

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Co-immobilization of lipase, glycerol kinase, glycerol-3-phosphate oxidase and peroxidase on to aryl amine glass beads affixed on plastic strip for determination of triglycerides in serum. (2008)

Commercial lipase, glycerol kinase (GK), glycerol-3-phosphate oxidase (GPO) and peroxidase (POD) have been co-immobilized covalently on to arylamine glass beads affixed on a plastic strip through diazotization with a conjugation yield of 89.1 mg/g support and 64.1% retention of specific activity. The co-immobilized enzymes showed maximum activity at pH 7.5, when incubated at 40 degrees C for 20 min. The strip was employed for determination of serum triglycerides (Tgs). The minimum detection limit of the method was 0.20 mM/L. The recovery of added Tgs was 88.0%. Within day and between day coefficient of variations were <7.0 % and <11.0%, respectively. A good correlation (r = 0.982) was observed between total serum Tgs values obtained by present method and the most commonly used enzymic colorimetric method, employing free enzymes. Among the various serum substances tested at their physiological concentrations, only cholesterol, ascorbic acid and bilirubin caused 30%, 15%, and 20% inhibition of strip-bound enzymes, respectively. The strip lost 50% of its activity after 150 regular uses over a period of 33 days, when stored in reaction buffer at 4 degrees C. The method reported here has the advantage over other existing methods, as it provides higher sensitivity, better stability and reusability of co-immobilized enzymes and is also economical.
Advancements in electrodynamic wireless power transmission (2016)

This article summarizes recent advancements in near-field electrodynamic wireless power transmission (EWPT), which relies on a time-varying magnetic field produced by a transmitter to excite the mechanical motion of permanent magnet in the receiver. The mechanical energy absorbed by the magnet is then converted into electrical energy via one or more transduction mechanisms, most commonly Faraday induction. EWPT is compared against other wireless power strategies, and theoretical upper bounds of power transmission are provided.
Activation of lymphocyte proliferation by boronate-containing polymer immobilised on substrate: The effect of boron content on lymphocyte proliferation (2006)

This study demonstrates that boronic acid-containing polymers coated onto solid support function as synthetic mitogens for mouse lymphocytes. The polymer was synthesized by radical copolymerization of 3-acrylamidophenylboronic acid with dimethylacrylamide (poly(AAPBA-DMAA)). The boronic acid in the trigonal form in the copolymer activated lymphocytes, probably by crosslinkage to glycoprotein moieties on the plasma membrane surface, as in the case of lectin stimulation. A higher concentration of phenylboronic acid on the copolymer surface resulted in greater activation of lymphocytes, suggesting that the number of phenylboronic acid residues per unit area may be a crucial factor in lymphocyte proliferation. The proliferative response of lymphocytes was also affected by the surface wettability, probably due to a difference in the flexibility of polymer strands at the cell-polymer interface.
Structure-Property Relationships for Organic Nonlinear Optical Materials (2006)

The real and imaginary third-order nonlinear optical properties of organic and metallo-organic materials will be discussed, highlighting promising materials for two- photon absorption and all optical switching.