gebhart/patrepeval huggingface dataset:
Coriolus versicolor ( Yunzhi ) Use as Therapy in Advanced Hepatocellular Carcinoma Patients with Poor Liver Function or Who Are Unfit for Standard Therapy (2017)

There was no difference in TTP with use of CV compared to placebo. CV subjects generally had better QOL on treatment compared to placebo subjects. The utility of this supplement in patients whose primary treatment goal is palliation should be further explored.
Surgery of coronary artery disease (1986)

Coronary surgery in the 21st century - a perspective the pathophysiology of myocardial perfusion pathology of ischemic heart disease coronary angiography nuclear imaging in coronary artery disease magnetic resonance imaging in coronary artery disease percutaneous coronary interventions indications for surgery in coronary artery disease anaesthetic and perioperative management in coronary surgery techniques of coronary surgery utilizing cardiopulmonary bypass techniques of coronary surgery without cardiopulmonary bypass the complications of coronary surgery conduits for coronary surgery coronary endartectomy management of the atherosclerotic ascending aorta repeat coronary surgery surgical interventions in acute ischaemia surgery for the chronic complications of coronary disease combined procedures the impact of coronary surgery on symptoms and prognosis predicting, evaluating and improving results of coronary artery bypass surgery the role of risk factor modifications management of refractory angina not amenable to conventional therapy.
Modeling and visualizing the cultural heritage data set of Graz (2001)

The inner city (Old Town) of Graz will be the European cultural capital in 2003. In this paper we present preliminary results on the reconstruction and visualization of this kind of cultural heritage data. Starting with a simple block model obtained by converting 2 1/2 dimensional GIS (geographic information system) data we focus on the image based modeling of the facades. Herein we illustrate a robust search for corresponding points to estimate the relative orientation between image pairs.Additional, we outline our real-time rendering approach based on a LOD-R-tree concept. Special attention is paid on the LOD (level of detail) generation for historic buildings where two different ways working in 2D and 3D are explained. The visualization system is communicating asynchronously with a database system storing the LOD-R-tree data structure. This client-server configuration provides interactive navigation through the virtual scene and the scalability of a database management system.
Advances in discriminative parsing (2006)

The present work advances the accuracy and training speed of discriminative parsing. Our discriminative parsing method has no generative component, yet surpasses a generative baseline on constituent parsing, and does so with minimal linguistic cleverness. Our model can incorporate arbitrary features of the input and parse state, and performs feature selection incrementally over an exponential feature space during training. We demonstrate the flexibility of our approach by testing it with several parsing strategies and various feature sets. Our implementation is freely available at: http://nlp.cs.nyu.edu/parser/.
Modelling Multivariate Extreme Flood Events (2006)

Cost benefit analysis, and other measures of economic risk, needs to take account of several characteristics of flood events if a realistic assessment of flood damage is to be made. Crucial characteristics might typically include the peak flow, the total volume of water above some threshold, and the duration of the inundation. The last mentioned is of particular importance for rice crops in Asia. Realistic modelling of these floods typically requires fitting a trivariate extreme value distribution with a carefully chosen dependence structure. Two approaches are compared. The first utilises copulas, which are multivariate uniform distributions. To begin with, the marginal distributions of the variables are estimated and then transformed to uniform distributions. Then the dependence structure, in this transformed space, is modelled by one of a large variety of possible analytic models or a non-parametric form. The second approach is to fit conditional distributions using regression type methods, such as an empirical Gibbs sampler. The empirical Gibbs sampler is particularly flexible as the variance of the conditional distributions can easily be related to the values of the other variables. Comparisons will be made of the ability of the various models to approximate known distributions. Practical cases will include the annual flood on the Mekong. Non-stationarity, and possible links with climatic indicators, such as El Nino, will be explored.
Triplifying Wikipedia's tables (2013)

We are currently investigating methods to triplify the content of Wikipedia's tables. We propose that existing knowledge-bases can be leveraged to semi-automatically extract high-quality facts (in the form of RDF triples) from tables embedded in Wikipedia articles (henceforth called \Wikitables"). We present a survey of Wikitables and their content in a recent dump of Wikipedia. We then discuss some ongoing work on using DBpedia to mine novel RDF triples from these tables: we present methods that automatically extract 24.4 million raw triples from the Wikitables at an estimated precision of 52.2%. We believe this precision can be (greatly) improved through machine learning methods and sketch ideas for features that should help classify (in)correct triples.
Pyrogallol red‐molybdate: A reversible, metal chelate stain for detection of proteins immobilized on membrane supports (1996)

Certain metal complexes selectively interact with proteins immobilized on solid-phase membrane supports to form brightly colored products. The metal chelates form protein-dye complexes in the presence of metal ions at acidic pH but are eluted from the proteins by immersing membranes in a solution of basic pH that contains other chelating agents. The reversible nature of the protein staining procedure allows for subsequent biochemical analyses, such as immunoblotting, N-terminal and internal protein sequencing. Among the metal complexes evaluated to date, the triazine dye-ferrous complexes (ferene S, ferrozine) and the ferrocyanide-ferric complexes provide the most sensitive detection of proteins immobilized on membranes. While the pyrogallol red-molybdate complex is commonly used in solution-based total protein assays, its utility as a reversible stain for proteins immobilized on membranes has not been reported. Pyrogallol red-molybdate complexes readily stain proteins on nitrocellulose and polyvinyl difluoride membranes with similar sensitivity as ferrozine-ferrous complexes. Analysis of charge-fractionated carrier ampholytes and synthetic polymers of different L-amino acids indicate that binding is prominently via protonated alpha and epsilon-amino side chains. Carbamylation of amino groups in bovine serum albumin substantially diminishes pyrogallol red-molybdate binding to the protein. The stain is reversible, resistant to chemical interference, and compatible with immunoblotting.
Mononuclear iron complexes relevant to nonheme iron oxygenases. Synthesis, characterizations and reactivity of Fe-Oxo and Fe-Peroxo intermediates (2009)

The new ligand L(6)(2)4E (N,N,N',N'-tetrakis(5-ethyl-2-pyridylmethyl)ethane-1,2-diamine) was designed as a more robust analog of TPEN (N,N,N',N'-tetrakis(2-pyridylmethyl)ethane-1,2-diamine) for which the ability at stabilizing high valent Fe-Oxo and Fe-(hydro)peroxo has been reported. With respect to the latter, the pyridyl beta-substituents in L(6)(2)4E do not modify the Fe coordination chemistry. From the Fe(II) precursor, [FeO](2+) and Fe(III)-(hydro)peroxo intermediates are prepared using the same synthetic methods as those reported for the TPEN analogs. The spectroscopic characteristics of all L(6)(2)4E-Fe complexes are very similar to their TPEN analog. However, [(L(6)(2)4E)FeO](2+) has a greater lifetime than that of [(TPEN)FeO](2+). This can be explained by a restricted bimolecular autodegradation due to the bulkiness provided by the ethyl substituents. Regarding small organic molecule oxidation, [(L(6)(2)4E)FeO](2+) and [(L(6)(2)4E)FeOOH](2+) exhibit behaviours that seem to be general for the complexes built with ligands of the TPEN family: [FeO](2+) appears to be efficient to epoxidize olefins, whereas [FeOOH](2+) hydroxylates the aromatic ring of anisole with efficacy.
Growth of Acinetobacter calcoaceticus on Ethanol (1973)

A soil microorganism, identified as Acinetobacter calcoaceticus, was cultivated on ethanol as a sole source of carbon. This organism grew with a maximum specific growth rate of 0.7/h. The pH optimum for growth was between 6.5 and 7.5, and the temperature optimum was between 32 and 35 C. Ethanol metabolism by this organism was inducible by ethanol, and the presence of acetate led to the repression of ethanol dehydrogenase. At higher cell densities the cessation of growth on ethanol was accompanied by the accumulation of acetate or acetaldehyde, or both. These accumulations were attributed to a reduction in the magnesium or sulfur content of the medium and a lack of feedback inhibition by acetate of alcohol dehydrogenase.
3D rapid prototyping to model DNA replication and engage students in the scientific process (2010)

DNA replication is a vital process in all organisms and understanding the fundamental biochemical interactions that drive replication is essential. Single‐stranded DNA‐binding (SSB) proteins form an important component of the replication machinery that facilitates the transfer of RNA primers from the enzyme primase to the replicative polymerase. This activity occurs throughout lagging‐strand DNA replication. The crystal structure of the E. coli χψ subunit of the DNA polymerase III holoenzyme bound to its interaction site on SSB has been determined. The Madison West High School Students Modeling a Research Topic (SMART) Team, in collaboration with the Milwaukee School of Engineering, has modeled this interaction using 3D Rapid Prototyping Technology to gain insights into the physical interactions that drive DNA replication. The SMART team program allows students to experience the scientific process beyond the textbook by investigating the experimental methodology of structural biology and takes students out of the classroom and into the laboratory. Supported by grants from the Howard Hughes Medical Institute and NIH‐NCRR‐SEPA.
A ROLE FOR NITRIC OXIDE IN ENDOTOXIN-INDUCED DEPLETION OF THE PERIPHERAL CATECHOLAMINE STORES (2000)

Endotoxemia is associated with increased sympathetic nerve activity and depletion of norepinephrine (NE) and epinephrine (EPI) contents in the adrenal gland and in sympathetically innervated tissues. Endotoxin (bacterial lipopolysacchride [LPS]) causes an increased production of nitric oxide (NO) by inducing nitric oxide synthase (iNOS) expression in various tissues. This increased production of NO contributes significantly to the hypotension associated with endotoxemia. At high concentrations, NO also can act as a neurotoxin. In this study we tested the hypothesis that increased production of NO is involved in depletion of catecholamine content in various tissues from rats treated with a nonlethal dose of LPS. Catecholamine content was measured by high-performance liquid chromatography with electrochemical detection (HPLC-EC) and NOS activity was measured by the 3H-I-arginine to 3H-I-citrulline conversion method. The NE content was decreased in rat adrenal gland, lung, spleen, tail artery, and aorta after LPS. The maximal decrease was at 24 h and returned to control levels at 6 days (144 h). There was no depletion of the NE content in the heart. The EPI content in the adrenal gland was greatly depleted (91%) from 12 to 72 h after LPS. LPS increased the NOS activity in all tissues examined. The time course for NOS activity showed an increase at 3 h, a further increase at 6 h, and a return to control level at 48 h after LPS. The increase in NOS activity occurred before maximal catecholamine depletion. Aminoguanidine, a relatively selective iNOS inhibitor, completely prevented NE depletion in all tissues and partially prevented adrenal EPI depletion induced by LPS. These results are consistent with the hypothesis that LPS-induced production of NO plays a role in depletion of tissue NE and EPI.
Why Caregiver Depression, and Self-Care Abilities Should Be Part of the PPS Case Mix Methodology (2001)

The Abt case mix study and the PPS Demonstration Project showed only certain OASIS items were accurate predictors of care needs in the parameters set by the researchers; thus, only 22 OASIS items were factored in the case mix indicators for reimbursement. In this interview, Dr. Jeffrey Elias, a nationally known gerontologist and researcher, explains how the chosen OASIS items and their relevance to accurate reimbursement can be examined in the context of gerontology research. Two OASIS indicators omitted from the case mix—the presence of a caregiver and assessment of the patient’s psychological status—are seen by Dr. Elias as critical to determining client needs and, therefore, should be linked to reimbursement.
Actualités sur les bartonelloses. Discussion : Les zoonoses émergentes ou réémergentes (1999)

Parmi les 13 especes de Bartonella actuellement decrites, 6 ont un role pathogene chez l'homme. B. bacilliformis est responsable de la maladie de Carrion et B. quintana de la fievre des tranchees et de differents syndromes dont l'angiomatose bacillaire. La maladie des griffes de chat et des angiomatose-peliose bacillaire sont dues a B. henselae. Trois autres especes ont un pouvoir pathogene moins affirme : B. clarridgeiae, B. elizabethae et B. vinsonii subsp. arupensis. L'epidemiologie des bartonelloses est dominee par l'existence d'un reservoir mammifere et le role central joue par les arthropodes dans la transmission ou la dissemination des bacteries. Les connaissances actuelles concernant l'etiologie, l'epidemiologie et les manifestations cliniques de ces infections ainsi que leur diagnostic, traitement et prevention sont presentees.
Abstract 457: Significance of angiotensin targeting on treatment of liver metastasis in colorectal cancer patients with diabetes (2012)

Abstract We examined the effects of hyperglycemic conditions on liver metastasis of colorectal cancer (CRC). Angiotensin (AT)-II increased growth, invasion, and anti-apoptotic survival in HT29 and CT26 cells. In contrast, angiotensinogen (ATG) increased these features in HT29 cells but not in CT26 cells. HT29 cells expressed AT-II type 1 receptor, chymase, and rennin, whereas CT26 cells did not express renin. Renin expression and ATG-induced cell growth, invasion, and survival induced and increased as glucose concentration increased in HT29 cells and also CT26 cells. An inhibitor of renin or chymase abrogated A-II production in both cells. Reduction of hepatic ATG production by knockdown suppressed liver metastasis of HT29 cells. An examination of 121 CRC patients showed that diabetes in CRC cases was associated with higher blood HbA1c, higher renin and AT-II concentrations in the primary tumors, and higher incidence of liver metastasis than in nondiabetic cases. These results suggest that diabetes-associated AT activation enhances liver metastasis of CRC. We then examined an antimetastatic therapy by anti-AT treatments in CRC. In a streptozotocin-induced BALB/c mouse diabetes model that was fed a high-calorie diet, the blood sugar level increased and was associated with enhanced CT26 liver metastases. In this diabetic mouse model, liver metastasis of CT26 cells was suppressed by anti-AT treatment with a chymase inhibitor, a renin inhibitor, and an AT-II receptor blocker. Moreover, concurrent hypoglycemic and anti-AT treatments showed a synergistic inhibitory effect on CT26 cell liver metastasis. These results suggest that AT activation ability associated with diabetic conditions enhances liver metastasis of colon cancer. Therefore, treatment with anti-AT and hypoglycemic agents might be relevant for suppressing liver metastasis. This scheme should be examined in a clinical setting. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 457. doi:1538-7445.AM2012-457
Leveraging 3D chemical similarity, target and phenotypic data in the identification of drug-protein and drug-adverse effect associations (2016)

The modeling described in the current study is simple and efficient and has applications at large scale in drug repurposing and drug safety through the identification of mechanism of action of biological effects.
Demixing of Binary Water−Chloroform Mixtures Containing Ionophoric Solutes and Ion Recognition at a Liquid−Liquid Interface:  A Molecular Dynamics Study (1998)

We report a series of molecular dynamics simulations on the demixing of “homogeneous” binary water−chloroform mixtures containing species involved in the assisted ion extraction process. We consider an ionophore L (L = 1,3-alternate calix4arene-crown6), uncomplexed salts of Cs+ and the LCs+ and LNa+ cation complexes with a lipophilic (Pic-) and a hydrophilic (Cl-) counterion, respectively, as being solutes. In all cases, the liquids separate rapidly, leading to two solvent slabs separated by a well-defined interface. However, the final state is very different, depending on the hydrophilic/hydrophobic balance of the solutes: the Cs+ and NO3- ions of the CsNO3 salt are completely immersed in the aqueous phase, whereas Pic- anions display a strong adsorption at the interface. The LCs+ complex and the free ligand L, although more soluble in the organic phase than in water, also display a surfactant like behavior. Similar conclusions are obtained when L, LCs+, Cs+ Pic-, and Cs+ NO3- ions are simultaneously present in the solution. On the basis of free energy perturbation calculations on LM+ complexes, we calculate a marked Cs+/Na+ recognition by L at the interface. These results have important implications concerning the mechanism of ionophore assisted liquid−liquid ion extraction and recognition processes at the interface.
Bounded search for de novo identification of degenerate cis-regulatory elements (2006)

The relationship between statistical measures of the binding sites and the set as a whole leads to a simple means of identifying the diverse range of cis-regulatory elements to which a protein binds. This approach leverages the advantages of word-counting, in that position dependencies are implicitly accounted for and local optima are more easily avoided. While we sacrifice guaranteed optimality to prevent the exponential blowup of exhaustive search, we prove that the error is bounded and experimentally show that the performance is superior to other methods. A Java implementation of this algorithm can be downloaded from our web server at http://genie.dartmouth.edu/prism.
Shunting Inhibition as a Neural-Inspired Mechanism for Multiplication in Neuromorphic Architectures (2023)

Shunting inhibition is a potential mechanism by which biological systems multiply two time-varying signals, most recently proposed in single neurons of the fly visual system. Our work demonstrates this effect in a biological neuron model and the equivalent circuit in neuromorphic hardware modeling dendrites. We present a multi-compartment neuromorphic dendritic model that produces a multiplication-like effect using the shunting inhibition mechanism by varying leakage along the dendritic cable. Dendritic computation in neuromorphic architectures has the potential to increase complexity in single neurons and reduce the energy footprint for neural networks by enabling computation in the interconnect.
Dielectric Dispersion and High Field Response of Multilayer Hexagonal Boron Nitride (2018)

Abstract The dielectric dispersion of a material holds significant importance for the understanding of basic material characteristics and the design parameters of a functional device. Here, the dielectric dispersion characteristics of multilayer hexagonal boron nitride (hBN) using time domain reflectometry under an extended device operating frequency range up to 100 MHz are studied. Contrary to what is previously reported, the capacitance, hence the effective dielectric constant, of hBN decreases with the increase of frequency above the MHz range, indicating heat dissipation in lossy hBN dielectric. Furthermore, hBN shows stubborn dielectric characteristics with temperature changes that confirm its thermal stability in extreme operating conditions. The charge carriers in hBN are transported by Fowler–Nordhiem tunneling with increasing the electrical field. Lastly, hBN endures electrical field of 7.8 MV cm −1 that implies its potential use as a promising dielectric material. These results will benefit the research and development of hBN supported high‐speed electronics operated at high‐frequency conditions for energy‐efficient device applications.
Enhanced interactive gaming by blending full-body tracking and gesture animation (2010)

Animating in-game avatars using real time motion capture data is highly appealing and is becoming more widespread due to the accessibility of researchers and developers to consumer priced depth sensors [Microsoft Kinect 2010]. Depth sensors allow for a cheap and robust motion capture solution which can be naturally adapted to games. However, in spite of the many advantages of using real-time motion capture data for animating avatars in games, there are two major challenges. The first is due to the limitations of the current tracking techniques in producing smooth, noise free, accurate animation in real-time. The second, and more acute problem, stems from the fact that in most games, the movements of the animated avatar are expected to be more expressive than the player's actual movements. In such cases, one would like to visually enhance the player's motion to display exaggerated or even super-natural motions.
Biocompatibility of silver-modified polyester for antimicrobial protection of prosthetic valves. (1997)

These current results, together with the earlier data, suggest that IBAD silver coating on polyester facilitates healing and may provide protection against PVE.
Guided gesture support in the paper PDA (2001)

Ordinary paper offers properties of readability, fluidity, flexibility, cost, and portability that current electronic devices are often hard pressed to match. In fact, a lofty goal for many interactive systems is to be "as easy to use as pencil and paper". However, the static nature of paper does not support a number of capabilities, such as search and hyperlinking that an electronic device can provide. The Paper PDA project explores ways in which hybrid paper electronic interfaces can bring some of the capabilities of the electronic medium to interactions occurring on real paper. Key to this effort is the invention of on-paper interaction techniques which retain the flexibility and fluidity of normal pen and paper, but which are structured enough to allow robust interpretation and processing in the digital world. This paper considers the design of a class of simple printed templates that allow users to make common marks in a fluid fashion, and allow additional gestures to be invented by the users to meet their needs, but at the same time encourages marks that are quite easy to recognize.