gebhart/patrepeval huggingface dataset:
Valence control, reactivity of oxygen, and catalytic activity of lanthanum strontium cobalt oxide (La2-xSrxCoO4) (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTValence control, reactivity of oxygen, and catalytic activity of lanthanum strontium cobalt oxide (La2-xSrxCoO4)Taihei Nitadori, Motohiko Muramatsu, and Makoto MisonoCite this: Chem. Mater. 1989, 1, 2, 215–220Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/cm00002a010https://doi.org/10.1021/cm00002a010research-articleACS PublicationsRequest reuse permissionsArticle Views294Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Levitational Image Cytometry with Temporal Resolution (2015)

A simple, yet powerful magnetic-levitation-based device is reported for real-time, label-free separation, as well as high-resolution monitoring of cell populations based on their unique magnetic and density signatures. This method allows a wide variety of cellular processes to be studied, accompanied by transient or permanent changes in cells' fundamental characteristics as a biological material.
A Review on Language Models as Knowledge Bases (2022)

Recently, there has been a surge of interest in the NLP community on the use of pretrained Language Models (LMs) as Knowledge Bases (KBs). Researchers have shown that LMs trained on a sufficiently large (web) corpus will encode a significant amount of knowledge implicitly in its parameters. The resulting LM can be probed for different kinds of knowledge and thus acting as a KB. This has a major advantage over traditional KBs in that this method requires no human supervision. In this paper, we present a set of aspects that we deem a LM should have to fully act as a KB, and review the recent literature with respect to those aspects.
Quality of Life is Improved and Kidney Function Preserved in Patients with Nephropathic Cystinosis Treated for 2 Years with Delayed-Release Cysteamine Bitartrate (2014)

The use of a DR-CYS administered every 12 hours to patients with cystinosis is of great benefit to their quality of life and to important biomarkers of disease control, when studied in a prospective, controlled fashion. We suggest that DR-CYS should be considered for substrate depletion in patients with cystinosis.
Mutations in the α8 Loop of Human APE1 Alter Binding and Cleavage of DNA Containing an Abasic Site (2003)

Recent crystallographic studies reveal loops in human AP endonuclease 1 (APE1) that interact with the major and minor grooves of DNA containing apurinic/apyrimidinic (AP) sites. These loops are postulated to stabilize the DNA helix and the flipped out AP residue. The loop alpha8 interacts with the major groove on the 3' side of the AP site. To determine the essentiality of the amino acids that constitute the alpha8 loop, we created a mutant library containing random nucleotides at codons 222-229 that, in wild-type APE1, specify the sequence NPKGNKKN. Upon expression of the library (2 x 10(6) different clones) in Escherichia coli and multiple rounds of selection with the alkylating agent methyl-methane sulfonate (MMS), we obtained approximately 2 x 10(5) active mutants that complemented the MMS sensitivity of AP endonuclease-deficient E. coli. DNA sequencing showed that active mutants tolerated amino acid substitutions at all eight randomized positions. Basic and uncharged polar amino acids together comprised the majority of substitutions, reflecting the positively charged, polar character of the wild-type loop. Asn-222, Asn-226, and Asn-229 exhibited the least mutability, consistent with x-ray data showing that each asparagine contacts a DNA phosphate. Substitutions at residues 226-229, located nearer to the AP site, that reduced basicity or hydrogen bonding potential, increased Km 2- to 6-fold and decreased AP site binding; substitutions at residues 222-225 exhibited lesser effects. This initial mutational analysis of the alpha8 loop supports and extends the conclusion of crystallographic studies that the loop is important for binding of AP.DNA and AP site incision.
A New Production Data Analysis Method of Shale Gas: Based on Flowing Material Balance Theory and Considering the Complex Flow Mechanisms of Multiple Pressure Systems (2019)

Shale gas has become one of the most important unconventional energy sources in ultra-low permeability reservoirs which has unique reservoir properties and exists in the form of free and adsorptive state in the reservoir, forming many kinds of flow mechanism. In this paper, we provide a new method for production data analysis of shale gas well based on the flowing material balance theory. This method can accurately and effectively evaluate the productivity of shale gas wells and the dropdown of formation energy. This new model divides SRV into matrix pressure system and hydraulic fracturing pressure system. Only 5 fitting parameters are needed to complete the productivity evaluation of shale gas well, and the pressure data of matrix system and hydraulic fracturing systems can be calculated by this model. Compared with the Hz Multifrac model in RTA, our model achieves better and more stable evaluation results in the application of typical production wells in many large shale gas fields, such as Fuling, Changning, Eagle Ford and Barnet.
Sex and age differences in the pharmacokinetics of alosetron (2002)

A significant difference in clearance by metabolism of alosetron between the sexes, and possibly between the young and elderly was observed.
Dimethyl fumarate for multiple sclerosis (2015)

There is moderate-quality evidence to support that dimethyl fumarate at a dose of 240 mg orally three times daily or twice daily reduces both the number of patients with a relapse and the annualised relapse rate over two years of treatment in comparison with placebo. However, the quality of the evidence to support the benefit in reducing the number of patients with disability worsening is low. There is no high-quality data available to evaluate the benefit on MRI outcomes. The common adverse effects such as flushing and gastrointestinal events are mild-to-moderate for most patients. Lymphopenia and leukopenia are uncommon adverse events but significantly associated with dimethyl fumarate. Both dosages of dimethyl fumarate have similar benefit and safety profile, which supports the option of low-dose administration. New studies of high quality and long-term follow-up are needed to evaluate the benefit of dimethyl fumarate on prevention of disability worsening and to observe the long-term adverse effects including progressive multifocal leukoencephalopathy.
Gene Delivery of Sarcoplasmic Reticulum Calcium ATPase Inhibits Ventricular Remodeling in Ischemic Mitral Regurgitation (2010)

In this controlled model, upregulating SERCA2a induced better function and lesser remodeling, with improved contractility, smaller volume, and activation of prohypertrophic/antiapoptotic pathways. Although caspase-3 remained activated in both groups, SERCA2a sheep had increased molecular antiremodeling "tone." We therefore conclude that upregulating SERCA2a inhibits MR-induced post-MI remodeling in this model and thus may constitute a useful approach to reduce the vicious circle of remodeling in ischemic MR.
Low-stretch greedy embedding heuristics (2012)

Greedy embedding is a graph embedding that makes the simple greedy packet forwarding scheme successful for every source-destination pair. It is desirable that graph embeddings also yield low hop stretch of the greedy over the shortest paths. In this paper we study how topological and geometric properties of embedded graphs influence the hop stretch. Based on the obtained insights, we construct embedding heuristics that yield minimal hop stretch greedy embeddings.
Robust Overnight Monitoring of Human Vital Signs by a Non-contact Respiration and Heartbeat Detector (2006)

A positive answer is given to the question intrigued by our previous work reported in EMBC 2005: whether it is possible for a non-contact physiological movement detector to detect vital signs from four sides of a human body. In addition to the proof from measured data, theoretical analysis confirms the surprising advantage of detection from the back of the body. Based on this observation, a non-contact system was set up to perform overnight monitoring of vital signs using low power radio waves. Measurement data is presented and analyzed. The challenges and key technologies that improved the performance of our system for overnight monitoring are discussed.
Ga‐Based Liquid Metal Micro/Nanoparticles: Recent Advances and Applications (2019)

Liquid metals are emerging as fluidic inorganic materials in various research fields. Micro- and nanoparticles of Ga and its alloys have received particular attention in the last decade due to their non toxicity and accessibility in ambient conditions as well as their interesting chemical, physical, mechanical, and electrical properties. Unique features such as a fluidic nature and self-passivating oxide skin make Ga-based liquid metal particles (LMPs) distinguishable from conventional inorganic particles in the context of synthesis and applications. Here, recent advances in the bottom-up and top-down synthetic methods of Ga-based LMPs, their physicochemical properties, and their applications are summarized. Finally, the current status of the LMPs is highlighted and perspectives on future directions are also provided.
Simulation Of RAM-Based Asynchronous Sequential Circuits (2005)

We have developed a computer simulator for the asynchronous sequential circuits (ASCs) constructed by using the random access memories (RAMs). This is a generic simulator with respect to the manufacturing technology of the RAM because all the time delays are variables and can be changed by the user. In addition, there is-no restriction on the RAM size. The simulated RAM can be programmed and then the simulator simulates the ASC with its direct feedback connections. The durations of the transition states are generated in a random fashion. The user can change the input state interactively from the keyboard and the output state of the ASC is continuously displayed on the monitor screen.
miR-34a Inhibits Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting MMP9 and MMP14 (2014)

miR-34a plays an important role in lymph node metastases of TSCC through targeting MMP9 and MMP14 and may have potential applications in prognosis prediction and gene therapy for lymph node metastases of TSCC patients.
IL-17A Enhances the Expression of Profibrotic Genes through Upregulation of the TGF-β Receptor on Hepatic Stellate Cells in a JNK-Dependent Manner (2014)

Activation of hepatic stellate cells (HSCs) is a key event in the initiation of liver fibrosis, characterized by enhanced extracellular matrix production and altered degradation. Activation of HSCs can be modulated by cytokines produced by immune cells. Recent reports have implicated the proinflammatory cytokine IL-17A in liver fibrosis progression. We hypothesized that IL-17A may enhance activation of HSCs and induction of the fibrogenic signals in these cells. The human HSC line LX2 and primary human HSCs were stimulated with increasing doses of IL-17A and compared with TGF-β- and PBS-treated cells as positive and negative controls, respectively. IL-17A alone did not induce activation of HSCs. However, IL-17A sensitized HSCs to the action of suboptimal doses of TGF-β as confirmed by strong induction of α-smooth muscle actin, collagen type I (COL1A1), and tissue inhibitor of matrix metalloproteinase I gene expression and protein production. IL-17A specifically upregulated the cell surface expression of TGF-βRII following stimulation. Pretreatment of HSCs with IL-17A enhanced signaling through TGF-βRII as observed by increased phosphorylation of SMAD2/3 in response to stimulation with suboptimal doses of TGF-β. This enhanced TGF-β response of HSCs induced by IL-17A was JNK-dependent. Our results suggest a novel profibrotic function for IL-17A by enhancing the response of HSCs to TGF-β through activation of the JNK pathway. IL-17A acts through upregulation and stabilization of TGF-βRII, leading to increased SMAD2/3 signaling. These findings represent a novel example of cooperative signaling between an immune cytokine and a fibrogenic receptor.
Statistical evaluation of vulnerability and expected seismic damage of residential buildings in the Veneto-Friuli area (NE Italy) (2008)

The European macroseismic scale EMS98, through the classification of buildings in vulnerability classes with a progressively decreasing level of seismic risk (from A to F) gives a coherent conceptual frame for a large scale evaluation of the seismic vulnerability of buildings. The theory of the random sets is used to derive the upper and lower bounds of relative frequencies of the damage grades for every class and macroseismic intensity from the qualitative measures of the scale. Preliminary classifications of the number of buildings and their volumes in every census section based on "poor" data obtained from national statistics, are verified through a first-level survey form in a sample of census sections in the provinces of Belluno, Treviso and Pordenone (NE Italy). The comparison allows us to make some proposals of corrective coefficients, based on simple linear or better robust regression
Retargeting azithromycin analogues to have dual-modality antimalarial activity (2020)

We show that azithromycin and analogues can rapidly kill malaria parasite asexual blood stages via a fast action mechanism. Development of azithromycin and analogues as antimalarials offers the possibility of targeting parasites through both a quick-killing and delayed-death mechanism of action in a single, multifactorial chemotype.
Determination of protein and moisture in wheat and barley by near-infrared transmission (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of protein and moisture in wheat and barley by near-infrared transmissionPhilip C. Williams, Karl H. Norris, and Debbie C. SoberingCite this: J. Agric. Food Chem. 1985, 33, 2, 239–244Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/jf00062a021https://doi.org/10.1021/jf00062a021research-articleACS PublicationsRequest reuse permissionsArticle Views494Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Using quantitative immunohistochemistry in patients at high risk for hepatocellular cancer (2022)

Hepatocellular carcinoma (HCC) is the primary form of liver cancer and a major cause of cancer death worldwide. Early detection is key to effective treatment. Yet, early diagnosis is challenging, especially in patients with cirrhosis, who are at high risk of developing HCC. Dysfunction or loss of function of the transforming growth factor β (TGF-β) pathway is associated with HCC. Here, using quantitative immunohistochemistry analysis of samples from a multi-institutional repository, we evaluated if differences in TGF-β receptor abundance were present in tissue from patients with only cirrhosis compared with those with HCC in the context of cirrhosis. We determined that TGFBR2, not TGFBR1, was significantly reduced in HCC tissue compared with cirrhotic tissue. We developed an artificial intelligence (AI)-based process that correctly identified cirrhotic and HCC tissue and confirmed the significant reduction in TGFBR2 in HCC tissue compared with cirrhotic tissue. Thus, we propose that a reduction in TGFBR2 abundance represents a useful biomarker for detecting HCC in the context of cirrhosis and that incorporating this biomarker into an AI-based automated imaging pipeline could reduce variability in diagnosing HCC from biopsy tissue.
CO2 Adsorption and Activation on the (110) Chalcopyrite Surfaces: A Dispersion-Corrected DFT + U Study (2019)

We have used the density functional theory within the plane-wave framework to understand the reconstruction of most stable (110) chalcopyrite surfaces. Reconstructions of the polar surfaces are proposed, and three different possible nonpolar terminations for the (110) surface, namely, I, II, and III, are investigated. A detailed discussion on stabilities of all three surface terminations is carried out. It is generally observed that the (110) chalcopyrite surfaces encounter significant reconstruction in which the metal Fe and Cu cations in the first atomic layer considerably move downward to the surface, while the surface S anions migrate slightly outward toward the surface. We also investigated the adsorption of the CO<sub>2</sub> molecule on the three terminations for the (110) surface by exploring various adsorption sites and configurations using density functional theory calculations, in which long-range dispersion interactions are taken into consideration. We show that the CO<sub>2</sub> molecule is adsorbed and activated, while spontaneous dissociation of the CO<sub>2</sub> molecule is also observed on the (110) surfaces. Structural change from a neutral linear molecule to a negatively charged (CO<sub>2</sub> <sup>-δ</sup>) slightly or considerably bent species with stretched C-O bond distances are highlighted for description of the activation of the CO<sub>2</sub> molecule. The results address the potential catalytic activity of the (110) chalcopyrite toward the reduction and conversion of CO<sub>2</sub> to the organic molecule, which is appropriate to the production of liquid fuels.
A linear rod-packing coordination polymer constructed from a non-linear dicarboxylate and the [Zn4O]6+ cluster (2013)

A 1-D coordination polymer, [Zn4O(1,2-BDC)3]n (1,2-BDC = 1,2-benezendicarboxyate), has been synthesized under solvothermal conditions and structurally characterized by single-crystal X-ray diffraction. The coordination polymer contains [Zn4O]6+ clusters with a central μ4-oxygen tetrahedrally coordinated by four Zn2+ ions, which stack into a linear rod connected by 1,2-BDC units.
Ultralow threshold multiquantum well InGaAs lasers (1992)

Ultralow threshold currents have been obtained in multiquantum well strained-layer InGaAs lasers. A cw threshold current of 1 mA in an uncoated double quantum well laser and a 0.35 mA (pulsed threshold current 0.25 mA) in a coated laser are demonstrated.
Allergen-Immuntherapie in der aktuellen COVID-19-Pandemie – ein Positionspapier von ARIA, EAACI, AeDA, GPA und DGAKI (Kurzversion) – Positionspapier der deutschen ARIA-GruppeA in Kooperation mit der österreichischen ARIA-GruppeB, der schweizerischen ARIA-GruppeC, dem Ärzteverband Deutscher Allergologen (AeDA)D, der Deutschen Gesellschaft fur Allergologie und Klinische Immunologie (DGAKI)E und der Gesellschaft fur Pädiatrische Allergologie (GPA)F in Kooperation mit der AG Klinische Immunologie, Allergologie und Umweltmedizin der DGHNO-KHCG und der Europäischen Akademie fur Allergologie und Klinische Immunologie (EAACI)H (2020)

International audience
Physical Activity Improves Long-Term Stroke Outcome via Endothelial Nitric Oxide Synthase–Dependent Augmentation of Neovascularization and Cerebral Blood Flow (2006)

Physical activity upregulates endothelial nitric oxide synthase (eNOS), improves endothelium function, and protects from vascular disease. Here, we tested whether voluntary running would enhance neovascularization and long-term recovery following mild brain ischemia. Wild-type mice were exposed to 30 minutes of middle-cerebral artery occlusion (MCAo) and reperfusion. Continuous voluntary running on wheels conferred long-term upregulation of eNOS in the vasculature and of endothelial progenitor cells (EPCs) in the spleen and bone marrow (BM). This was associated with higher numbers of circulating EPCs in the blood and enhanced neovascularization. Moreover, engraftment of TIE2/LacZ-positive BM-derived cells was increased in the ischemic brain. Four weeks after the insult, trained animals showed higher numbers of newly generated cells in vascular sites, increased density of perfused microvessels and sustained augmentation of cerebral blood flow within the ischemic striatum. Moreover, running conferred tissue sparing and improved functional outcome at 4 weeks. The protective effects of running on angiogenesis and outcome were completely abolished when animals were treated with a NOS inhibitor or the antiangiogenic compound endostatin after brain ischemia, and in animals lacking eNOS expression. Voluntary physical activity improves long-term stroke outcome by eNOS-dependent mechanisms related to improved angiogenesis and cerebral blood flow.
Wegener's granulomatosis masquerading as unilateral sinusitis. (2004)

Wegener's Granulomatosis (WG) is a rare, multi-system disease of unknown aetiology. The disease is characterised by necrotizing granulomas and vasculitis of the upper and lower respiratory tracts and kidneys. The sinonasal region may be the first area to manifest this systemic condition. If the disease is diagnosed early and treated appropriately, involvement of the lungs and kidneys may be averted. Left untreated, the disease may prove rapidly fatal. A low threshold of clinical suspicion must be maintained. We report a case, of a middle aged patient who presented with unilateral sinusitis secondary to a large obstructive nasal mass. Anti neutrophil cytoplasmic antibody (ANCA) titres helped confirm the diagnosis of WG. Unilateral sinusitis with a nasal mass, is a very unusual presentation of WG, and emphasises the importance of a low threshold of suspicion for patients presenting with atypical sinonasal symptoms.
L‐Proline—H2O2: A New Chemoselective Approach for Oxidation of Sulfides to Sulfoxides. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Methicillin-Resistant Staphylococcus aureus in Tertiary Care Institutions of the Canadian Prairies 1990-1992 (1994)

MRSA isolated in patients in tertiary care institutions in these three Canadian provinces usually is acquired prior to admission. A disproportionate number of isolates are identified in aboriginal Canadians. Epidemiologic typing was consistent with a polyclonal origin of MRSA in this geographic area.