gebhart/patrepeval huggingface dataset:
Enhanced expression of β 2 -microglobulin and HLA antigens on human lymphoid cells by interferon (1978)

Mononuclear cells from the blood of healthy normal humans were kept in cultures under nonstimulating conditions for 16 hr in the presence or absence of human interferon. The relative quantities of HLA antigens and beta(2)-microglobulin on the cultured cells were determined by quantitative immunofluorescence (fluorescence-activated cell sorter) and by the capacity of cells to absorb out cytotoxic antibodies against the relevant antigens. Interferons of different origin and purities enhanced the expression of HLA antigens and beta(2)-microglobulins, whereas membrane immunoglobulins and antigens recognized by antiserum raised against human brain and T cells were the same on interferon-treated and control cells. Similar interferon effects were observed on an Epstein-Barrvirus-negative Burkitt lymphoma cell line. The enhanced expression of histocompatibility antigen subsequent to intereferon treatment was observed on B- and T-enriched lymphocyte populations and was found to be dose dependent with the optimum with "physiological" concentrations of interferon. Pretreatment of lymphocytes with interferon for 2 hr was found to be as effective as having interferon present during the total culture period. The interferon-induced enhancement of antigen expression on cells was dependent on active protein synthesis.
Quality assurance handbook for air pollution measurement systems. Volume III. Stationary source specific methods (1979)

This Handbook includes quality assurance guidelines on stationary source emission measurements. Regardless of the scope and magnitude of the stationary source emission measurement program, there are a number of common considerations pertinent to the production of quality data. These common parameters are discussed in Section 3.0 of Volume III and include quality assurance guidelines in the areas of: (1) planning the test program; (2) general factors in stationary source testing; (3) chain-of-custody procedure; and (4) traceability protocol for gases used for continuous source emission monitors. The remainder of Volume III contains pollutant-specific quality assurance guidelines. Initially Volume III includes guidelines for the following pollutant-specific measurement systems: Section 3.5 Method 6 - determination of sulfur dioxide emissions from stationary sources, Section 3.6 Method 7 - determination of nitrogen oxide emissions from stationary sources, and Section 3.7 Method 8 - determination of sulfuric acid mist and sulfur dioxide from stationary sources. Source testers and managers responsible for stationary source emission measurements will find Volume III useful in planning quality assurance.
Schémas numériques conservatifs pour des problèmes de vibro-impacts de poutres et de plaques (2011)

National audience
Initial results of NEXT-DEMO, a large-scale prototype of the NEXT-100 experiment (2013)

NEXT-DEMO is a large-scale prototype of the NEXT-100 detector, an electroluminescent time projection chamber that will search for the neutrinoless double beta decay of 136 Xe using 100-150 kg of enriched xenon gas. NEXT-DEMO was built to prove the expected performance of NEXT-100, namely, energy resolution better than 1% FWHM at 2.5 MeV and event topological reconstruction. In this paper we describe the prototype and its initial results. A resolution of 1.75% FWHM at 511 keV (which extrapolates to 0.8% FWHM at 2.5 MeV) was obtained at 10 bar pressure using a gamma-ray calibration source. Also, a basic study of the event topology along the longitudinal coordinate is presented, proving that it is possible to identify the distinct dE/dx of electron tracks in high-pressure xenon using an electroluminescence TPC.
Profiling DNA Damage Induced by the Irradiation of DNA with Gold Nanoparticles (2021)

The presence of gold nanoparticles (AuNPs) greatly enhances the formation of DNA damage when exposed to therapeutic X-rays. Three types of DNA damage are assessed in irradiated DNA by enzymatic digestion coupled to liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis. The major type of damage is release of the four nonmodified nucleobases, with a bias toward the release of cytosine and thymine. The second most important pathway involves the formation of several common reduction and oxidation products of DNA. Lastly, eight unique modifications of the 2-deoxyribose moiety are formed, which includes the 2',3'- and 2',5'-dideoxynucleosides (ddNs) of the four canonical nucleosides. The yield of ddNs decreases in the following order: ddG > ddA > ddC > ddT. From the yield and distribution of products, most of the damage is considered to arise from the generation of Auger/low-energy electrons (LEEs) and their reaction with DNA.
An Industrial IoT-Based Blockchain-Enabled Secure Searchable Encryption Approach for Healthcare Systems Using Neural Network (2022)

The IoT refers to the interconnection of things to the physical network that is embedded with software, sensors, and other devices to exchange information from one device to the other. The interconnection of devices means there is the possibility of challenges such as security, trustworthiness, reliability, confidentiality, and so on. To address these issues, we have proposed a novel group theory (GT)-based binary spring search (BSS) algorithm which consists of a hybrid deep neural network approach. The proposed approach effectively detects the intrusion within the IoT network. Initially, the privacy-preserving technology was implemented using a blockchain-based methodology. Security of patient health records (PHR) is the most critical aspect of cryptography over the Internet due to its value and importance, preferably in the Internet of Medical Things (IoMT). Search keywords access mechanism is one of the typical approaches used to access PHR from a database, but it is susceptible to various security vulnerabilities. Although blockchain-enabled healthcare systems provide security, it may lead to some loopholes in the existing state of the art. In literature, blockchain-enabled frameworks have been presented to resolve those issues. However, these methods have primarily focused on data storage and blockchain is used as a database. In this paper, blockchain as a distributed database is proposed with a homomorphic encryption technique to ensure a secure search and keywords-based access to the database. Additionally, the proposed approach provides a secure key revocation mechanism and updates various policies accordingly. As a result, a secure patient healthcare data access scheme is devised, which integrates blockchain and trust chain to fulfill the efficiency and security issues in the current schemes for sharing both types of digital healthcare data. Hence, our proposed approach provides more security, efficiency, and transparency with cost-effectiveness. We performed our simulations based on the blockchain-based tool Hyperledger Fabric and OrigionLab for analysis and evaluation. We compared our proposed results with the benchmark models, respectively. Our comparative analysis justifies that our proposed framework provides better security and searchable mechanism for the healthcare system.
Blood supply of the lower thoracic and lumbosacral regions. Postmortem aortography in 38 young adults. (1994)

Postmortem aortography was performed in 38 adults, aged 17 to 29 years, to elucidate the normal anatomy of the arteries supplying the lower thoracic and lumbosacral regions. The lowest 3 thoracic segmental arteries, examined in 32 cases, ran symmetrically in 27 cases. In 5 cases (16%) their course was asymmetric; on one side every segment was fed by an artery of its own, whereas on the other side a segmental artery fed 2 or more segments. The course, distribution and size of the 1st to 4th lumbar arteries were constant in every case except one, while the middle sacral artery and its branches, the 5th lumbar arteries, varied in size, being frequently compensated for, partly or wholly, by the iliolumbar arteries derived from the internal iliac arteries. In their course around the vertebral bodies, lumbar arteries frequently passed between and beneath fibrous attachments of the crura of the diaphragm and the psoas muscle.
The Length of Fibroin Structural Gene Sequences in Bombyx mori DNA (1974)

The mRNA that codes for silk fibroin in the silkworm Bombyx mori can be isolated in greater than 90% purity as judged by partial sequence analysis (Suzuki and Brown, 1972). Molecular hybridization experiments using highly purified fibroin mRNA have established that there are one to three genes per haploid complement of DNA in all tissues investigated, including the posterior silk gland where fibroin is synthesized (Suzuki et al., 1972).
The Structure and Stability of an HLA-A*0201/Octameric Tax Peptide Complex with an Empty Conserved Peptide-N-Terminal Binding Site (2000)

The crystal structure of the human class I MHC molecule HLA-A2 complexed with of an octameric peptide, Tax8 (LFGYPVYV), from human T cell lymphotrophic virus-1 (HTLV-1) has been determined. This structure is compared with a newly refined, higher resolution (1.8 A) structure of HLA-A2 complexed with the nonameric Tax9 peptide (LLFGYPVYV) with one more N-terminal residue. Despite the absence of a peptide residue (P1) bound in the conserved N-terminal peptide-binding pocket of the Tax8/HLA-A2 complex, the structures of the two complexes are essentially identical. Water molecules in the Tax8 complex replace the terminal amino group of the Tax9 peptide and mediate a network of hydrogen bonds among the secondary structural elements at that end of the peptide-binding groove. Thermal denaturation measurements indicate that the Tax8 complex is much less stable, DeltaTm = 16 degrees C, than the Tax9 complex, but both can sensitize target cells for lysis by some Tax-specific CTL from HTLV-1 infected individuals. The absence of a P1 peptide residue is thus not enough to prevent formation of a "closed conformation" of the peptide-binding site. TCR affinity measurements and cytotoxic T cell assays indicate that the Tax8/HLA-A2 complex does not functionally cross-react with the A6-TCR-bearing T cell clone specific for Tax9/HLA-A2 complexes.
Effects of furazlocillin, a beta-lactam antibiotic which binds selectively to penicillin-binding protein 3, on Escherichia coli mutants deficient in other penicillin-binding proteins (1981)

Furazlocillin binds selectively to penicillin-binding protein 3 (PBP-3), prevents septation of Escherichia coli, and allows the cells to form long filaments without lysis. The effect of furazlocillin on the morphology, autolysis, and murein synthesis of E. coli mutants deficient in either PBP-1A, PBP-1Bs, or PBP-2 was studied. The results reveal that PBP-1A and PBP-1Bs functions are not equivalent since furazlocillin affects the morphology, autolysis, and murein synthesis of PBP1A- mutants quite differently from that of PBP-1Bs mutants. Different "PBP-2-" mutants were found to respond to furazlocillin in dramatically different ways: strain LS-1 cells formed elongated rods with a central bulge which eventually lysed, whereas SP6 cells formed stable "barbells" in which the two daughter cells were well separated but remained connected by a thick central region.
The Impact of Facet Dislocation on Clinical Outcomes After Cervical Spinal Cord Injury (2012)

Compared with patients without FD, cervical SCI patients with FD tended to present with a more severe degree of initial injury and displayed less potential for motor recovery at 1-year follow-up.
An in situ and ex situ TEM study into the oxidation of titanium (IV) sulphide (2017)

Abstract Titanium (IV) sulphide (TiS 2 ) is a layered transition metal dichalcogenide, which we exfoliate using liquid phase exfoliation. TiS 2 is a candidate for being part of a range of future technologies. These applications are varied, and include supercapacitor and battery energy storage devices, catalytic substrates and the splitting of water. The driving force behind our interest was as a material for energy storage devices. Here we investigate a potential failure mechanism for such devices, namely oxidation and subsequent loss of sulphur. This degradation is important to understand, since these applications are highly property-dependent, and changes to the chemistry will result in changes in desired properties. Two approaches to study oxidisation were taken: ex situ oxidation by water and oxygen at room temperature and in situ oxidation by a 5% O 2 /Ar gas at elevated temperatures. Both sources of oxygen resulted in oxidation of the starting TiS 2 flakes, with differing morphologies. Water produced amorphous oxide slowly growing in from the edge of the flakes. Oxygen gas at ≥375 °C produced crystalline oxide, with a range of structures due to oxidation initiating from various regions of the observed flakes.
Sulfhydryl-Dependent Aggregation Accompanying the Denaturation of Bovine Plasma Albumin by Urea1,2 (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfhydryl-Dependent Aggregation Accompanying the Denaturation of Bovine Plasma Albumin by Urea1,2Verne D. Hospelhorn, Barbara Cross, and Elwood V. JensenCite this: J. Am. Chem. Soc. 1954, 76, 10, 2827–2829Publication Date (Print):May 1, 1954Publication History Published online1 May 2002Published inissue 1 May 1954https://pubs.acs.org/doi/10.1021/ja01639a066https://doi.org/10.1021/ja01639a066research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Resin Hemoperfusion: A New Treatment for Acute Drug Intoxication (1971)

A resin-column hemoperfusion system was used to treat four patients with profound, life-threatening drug intoxication. The column contained 650 g of pyrogen-free resin, Amberlite XAD-2. The resin is uncharged and has a cross-linked, polystyrene macroreticular structure with particular surface attraction for high-molecular-weight, lipid-soluble molecules. Blood was pumped through the column at a flow rate of 300 ml per minute for three hours. Two patients had secobarbital, one a mixture of glutethimide-butabarbital-ethchlorvynol, and one amobarbital intoxication. In all patients the column clearances of these drugs were markedly superior to known clearances with hemodialysis. A transient, modest fall in blood platelet concentration followed hemoperfusion. No serious clinical toxic effects were noted. The resin-column hemoperfusion system was technically simpler, consistently more effective and clinically superior to hemodialysis.
Asthma and breast feeding (2001)

Wright et al 1 found an increased risk for asthma and wheeze in breastfed children whose mothers had asthma themselves. Data on 9644 children aged 5–6 years from the Bavarian farmers' study2 allowed us to test whether this somewhat unexpected finding is reproducible in a different setting.

Lifetime prevalence of doctor diagnosed asthma (physicians' …
Influence of Random Excitations on Acoustic Instabilities in Combustion Chambers (2000)

Although flows in combustors contain considerable noise, arising from several kinds of sources, there is a sound basis for treating organized oscillations as distinct motions. That has been an essential assumption incorporated in virtually all treatments of combustion instabilities. However, certain characteristics of the organized or deterministic motions seem to have the nature of stochastic processes. For example, the amplitudes in limit cycles always exhibit a random character, and even the occurrence of instabilities seems occasionally to possess some statistical features. Analysis of nonlinear coherent motions in the presence of stochastic sources is, therefore, an important part of the theory. We report a few results for organized oscillations in the presence of noise. The most significant deficiency is that, because of the low level of current understanding, the stochastic sources of noise are modeled in ad hoc fashion and are not founded on a solid physical basis appropriate to combustion chambers.
Modular Hydrogels for Drug Delivery (2012)

The development of novel drug delivery systems is an essential step toward controlled site-specific administration of therapeutics within the body. It is desirable for delivery vehicles to be introduced into the body through minimally invasive means and, these vehicles should be capable of releasing drug to their intended location at a controlled rate. Furthermore, it is desirable to develop drug delivery systems that are capable of in vivo to suffer degradation and to deliver the drug completely, avoiding the need to surgically remove the vehicle at the end of its useful lifetime. Hydrogels are of particular interest for drug delivery applications due to their ability to address these needs in addition to their good biocompatibility, tunable network structure to control the diffusion of drugs and, tunable affinity for drugs. However, hydrogels are also limited for drug delivery applications due to the often quick elution of drug from their highly swollen polymer matrices as well as the difficulty inherent in the injection of macroscopic hydrogels into the body. This paper presents an overview to the advances in hydrogels based drug delivery. Different types of hydrogels can be used for drug delivery to specific sites in the gastrointestinal tract ranging from the oral cavity to the colon. These novel systems exhibit a range of several peculiar properties which make them attractive as controlled drug release formulations. Moreover, such materials are biocompatible and can be formulated to give controlled, pulsed, and triggered drug release profiles in a variety of tissues.
Understanding the Role of Cycling to Urban Transit Stations through a Simultaneous Access Mode and Station Choice Model (2020)

Governments worldwide are aiming to increase sustainable mode use to increase sustainability, livability, and accessibility. Integration of bicycle and transit can increase catchment areas of transit compared with walking and thus provide better competition to non-sustainable modes. To achieve this, effective measures have to be designed that require a better understanding of the factors influencing access mode and station choice. At the national/regional level this has been thoroughly studied, but there is a knowledge gap at the urban level. This study aims to investigate which factors influence the joint decision for tram access mode and tram station choice. The joint investigation can identify trade-offs between the access and transit journeys. Furthermore, the effect of each factor on the bicycle catchment area is investigated. Using data from tram travelers in The Hague, Netherlands, a joint simultaneous discrete choice model is estimated. Generally, walking is preferred to cycling. The findings of this study suggest that access distance is one of the main factors for explaining the choice, where walking distance is weighted 2.1 times cycling distance. Frequent cyclists are more likely also to cycle to the tram station, whereas frequent tram users are less inclined to cycle. Bicycle parking facilities increase the cycling catchment area by 234 m. The transit journey time has the largest impact on the catchment area of cyclists. Improvements to the system, such as fewer stops, higher frequency (like light rail transit), or both, therefore would result in a much longer accepted cycling distance.
Synthesis of Polynitroxides Based on Nucleophilic Aromatic Substitution (2010)

The scope and limitations of the synthesis of polynitroxides by nucleophilic substitution of electron-deficient fluorinated aromatic compounds are described. The method provides a facile route to the formation of polynitroxides exhibiting strong electron exchange between nitroxide groups.
Unsupervised paradigm for information extraction from transcripts using BERT (2021)

Audio call transcripts are one of the valuable sources of information for multiple downstream use cases such as understanding the voice of the customer and analyzing agent performance. However, these transcripts are noisy in nature and in an industry setting, getting tagged ground truth data is a challenge. In this paper, we present a solution implemented in the industry using BERT Language Models as part of our pipeline to extract key topics and multiple open intents discussed in the call. Another problem statement we looked at was the automatic tagging of transcripts into predefined categories, which traditionally is solved using supervised approach. To overcome the lack of tagged data, all our proposed approaches use unsupervised methods to solve the outlined problems. We evaluate the results by quantitatively comparing the automatically extracted topics, intents and tagged categories with human tagged ground truth and by qualitatively measuring the valuable concepts and intents that are not present in the ground truth. We achieved near human accuracy in extraction of these topics and intents using our novel approach
Origin of thermal modal instabilities in large mode area fiber amplifiers (2012)

We present a dynamic model of thermal modal instability in large mode area fiber amplifiers. This model allows the pump and signal optical intensity distributions to apply a time-varying heat load distribution within the fiber. This influences the temperature distribution that modifies the optical distributions through the thermo-optic effect thus creating a feedback loop that gives rise to time-dependent modal instability. We describe different regimes of operation for a representative fiber design. We find qualitative agreement between simulation results and experimental results obtained with a different fiber including the time-dependent behavior of the instability and the effects of different cooling configurations on the threshold. We describe the physical processes responsible for the onset of the instability and suggest possible mitigation approaches.
Furosemide-induced severe hypokalemia with rhabdomyolysis without cardiac arrest (2013)

Furosemide abuse has to be considered even in underweight individuals, especially if they have a psychiatric instability or work in health care institutions.
Point of View: Posterior Lumbar Epidural Fat as a Functional Structure? (1997)

Associate Professor, Department of Anesthesiology Professor, Department of Radiology; Medical College of Wisconsin; Milwaukee, Wisconsin
In-Plane Stiffness and Yield Strength of Periodic Metal Honeycombs (2004)

In-plane mechanical properties of periodic honeycomb structures with seven different cell types are investigated in this paper. Emphasis is placed on honeycombs with relative density between 0.1 and 0.3, such that initial yield is associated with short column compression or bending, occurring prior to elastic buckling. Effective elastic stiffness and initial yield strength of these metal honeycombs under in-plane compression, shear, and diagonal compression (for cell structures that manifest in-plane anisotropy) are reported as functions of relative density. Comparison among different honeycomb structures demonstrates that the diamond cells, hexagonal periodic supercells composed of six equilateral triangles and the Kagome cells have superior in-plane mechanical properties among the set considered.