gebhart/patrepeval huggingface dataset:
La fitació de les tres mans de l'Horta de Torrent en 1783 (1994)

The WFS and BMI methods are not equivalent in determining EBW in adolescents and are not interchangeable. EBW(WFS) was ~3.5% higher than EBW(BMI). In adolescents with eating disorders, use of the BMI method will underestimate the degree of malnutrition compared with the WFS method. Which method better predicts meaningful clinical outcomes remains to be determined.
Dominant-negative isoforms of Tcf/Lef proteins in development and disease (2011)

Comment on: Vacik T, et al. Genes Dev 2011; 25:1783-95.
Three-octave-spanning supercontinuum generation and sub-two-cycle self-compression of mid-infrared filaments in dielectrics (2015)

We experimentally and numerically investigate the spectral and temporal structure of mid-infrared (mid-IR) filaments in bulk dielectrics with normal and anomalous group velocity dispersion (GVD) pumped by a 2.1 μm optical parametric chirped-pulse amplifier (OPCPA). The formation of stable and robust filaments with several microjoules of pulse energy is observed. We demonstrate a supercontinuum that spans more than three octaves from ZnS in the normal GVD regime and self-compression of the mid-IR pulse to sub-two-cycle duration in CaF<sub>2</sub> in the anomalous GVD regime. The experimental observations quantitatively agree well with the numerical simulations based on a three-dimensional nonlinear wave equation that reveals the detailed spatio-temporal dynamics of mid-IR filaments in dielectrics.
Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance (2019)

Myogenic vasoconstriction is an autoregulatory function of small arteries. Recently, G-protein-coupled receptors have been involved in myogenic vasoconstriction, but the downstream signalling mechanisms and the in-vivo-function of this myogenic autoregulation are poorly understood. Here, we show that small arteries from mice with smooth muscle-specific loss of G<sub>12</sub>/G<sub>13</sub> or the Rho guanine nucleotide exchange factor ARHGEF12 have lost myogenic vasoconstriction. This defect was accompanied by loss of RhoA activation, while vessels showed normal increases in intracellular [Ca<sup>2+</sup>]. In the absence of myogenic vasoconstriction, perfusion of peripheral organs was increased, systemic vascular resistance was reduced and cardiac output and left ventricular mass were increased. In addition, animals with defective myogenic vasoconstriction showed aggravated hypotension in response to endotoxin. We conclude that G<sub>12</sub>/G<sub>13</sub>- and Rho-mediated signaling plays a key role in myogenic vasoconstriction and that myogenic tone is required to maintain local and systemic vascular resistance under physiological and pathological condition.
Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury (1999)

Peroxynitrite formation and the subsequent activation of the nuclear enzyme, poly (adenosine diphosphate [ADP]-ribose) synthetase (PARS), has been implicated in the pathogenesis of several neurodegenerative disorders. Here, we demonstrate that nitrotyrosine, an indicator of peroxynitrite generation, and poly (ADP) ribose, a marker of PARS activation, were selectively localized within tissues from spinal cord-injured rats. Our data implicate a role for peroxynitrite production and PARS activation in the development of spinal cord trauma.
Improvements to the TMSBr method of peptide resin deprotection and cleavage: application to large peptides. (1997)

The original trimethylsilyl bromide (TMSBr) method of peptide resin deprotection and cleavage has been modified for convenience and applicability to larger peptides. Equal amounts of a 66-residue test peptide resin were cleaved by the standard hydrogen fluoride (HF) procedure, the original TMSBr method and the modified TMSBr method. The peptide profile from the original TMSBr cleavage procedure showed multiple products and a lower overall yield. In contrast, the modified TMSBr procedure gave high yields of crude products comparable in purity to those obtained by HF cleavage.
Cover Image, Volume 9, Issue 6 (2017)

In the Overview by Sangtani and Nag et al., the authors detail recent advances in multifunctional therapeutic nanoparticles (NPs) for drug delivery and imaging. The distinction is made between hard NPs such as quantum dots and gold NPs (where drug cargos are attached to the NP surface) and soft NPs such as liposomes and micelles (which allow both core loading and surface attachment). The image shows a cut away view of a mammalian cell interfaced with soft (foreground left) and hard (foreground right) NPs during the delivery of surface‐appended (green spheres) and core‐loaded (red rods) cargos. Illustration is courtesy Ella Maru Studio, Inc. DOI: 10.1002/wnan.1466 . image
Coated vesicles from rat liver and calf brain contain cryptic mannose 6-phosphate receptors. (1983)

Highly purified clathrin-coated vesicles, isolated from rat liver and calf brain, contain mannose 6-phosphate receptors. The coated vesicle receptors appear to have the same subunit molecular weight and similar binding affinity as the receptor previously purified from bovine liver and rat chondrosarcoma microsomes (Sahagian, G. G., Distler, J. J., and Jourdian, G. W. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 4289-4293 and Steiner, A. W., and Rome, L. H. (1982) Arch. Biochem. Biophys. 214, 681-687). There is a considerable (greater than 60-fold) enrichment of receptors in liver coated vesicles as compared to liver microsomes. Experiments carried out with intact and detergent-disrupted coated vesicles indicated that the receptors face toward the inside of the coated vesicles. The data suggest that coated vesicles are involved in the intracellular transport of the mannose 6-phosphate receptor.
An Advanced Braking and Stability Controller for Tow-Vehicle and Trailer Combinations (1993)

&lt;div class="htmlview paragraph"&gt;This paper presents an optimal control strategy for assigning wheel slips on all of the wheels of a tractor/trailer combination. Most ABS controllers work on a wheel by wheel or an axle by axle basis without consideration for overall system stability. This controller is based on a linear program (LP) and assigns wheel slips for each wheel in accordance with one of the following criteria: 1) During an emergency braking maneuver, optimal wheel slips are determined which maximize stopping while constraining the system to be stable, or 2) During a nonemergency braking maneuver, the controller is used to maximize stability while maintaining an achievable (commanded) deceleration.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Computer simulations, which modeled a full tanker truck, were run to compare the response of the proposed controller with two controllers which incorporated select-low control and individual control ABS systems on various axles. Emergency braking responses in the following maneuvers were compared: constant turn, straight line split mu surface, and constant turn on a split mu surface. The LP controller showed itself to be a superior controller, especially in the last simulation where it was the only controller able to maintain tractor/trailer stability.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Due to the control system complexity and extensive sensor requirements, implementation of the proposed controller would currently be practical only on specialized vehicles. But the simulation results presented here seem to justify the expense.&lt;/div&gt;
Visible optical spectra of [MATH]-irradiated uranium - doped ZBLAN fibres (1994)

Actinides, particularly uranium, are again of interest because these elements provide a broad spectroscopic tunability and open a new field of fibre laser applications. The uranium ion possesses many oxidation states, the most stable being U4+ and U6+. U3+ is an unusual oxidation state in fluorides. U3+ is of interest because it can provide an efficient laser emission of between 2 and 2.7 µm. We report visible absorption and fluorescence spectra of pure and γ-irradiated uranium - doped ZBLAN fibres. We show that γirradiation leads to a high reduction of U4+ into U3+, which is stable over a few years. Strong absorption bands of U4+ and U3+, centered at 650 nm and 860 nm respectively, enable us to estimate the change of the uranium oxidation state.
New quadric metric for simplifying meshes with appearance attributes (2003)

Complex triangle meshes arise naturally in many areas of computer graphics and visualization. Previous work has shown that a quadric error metric allows fast and accurate geometric simplification of meshes. This quadric approach was recently generalized to handle meshes with appearance attributes. In this paper we present an improved quadric error metric for simplifying meshes with attributes. The new metric, based on geometric correspondence in 3D, requires less storage, evaluates more quickly, and results in more accurate simplified meshes. Meshes often have attribute discontinuities, such as surface creases and material boundaries, which require multiple attribute vectors per vertex. We show that a wedge-based mesh data structure captures such discontinuities efficiently and permits simultaneous optimization of these multiple attribute vectors. In addition to the new quadric metric, we experiment with two techniques proposed in geometric simplification, memoryless simplification and volume preservation, and show that both of these are beneficial within the quadric framework. The new scheme is demonstrated on a variety of meshes with colors and normals.
Effect of benemycin and sodium succinate on metabolism of protons in mitochondria of guinea pig lung and liver tissues (1979)

The data of studies on proton metabolism in mitochondria of the guinea pig lungs and liver with application of benemycin and sodium succinate show that benemycin does not affect the metabolism of protons in the lungs and liver mitochondria. Sodium succinate activates the release of protons from the lungs and liver mitochondria in state 4 according to Chance. When using sodium succinate for reducing the effect of benemycin on theorganism it is found that sodium succinate inhibits the utilization of protons of the lungs and liver mitochondria in state 3 according to Chance and activates this release in state 4, thus favouring an increase in their concentration in the extra-mitochondrial space. Sodium succinate increases survival rate of animals which were administered benemycin to.
Genetic Maps and the Use of Synteny (2009)

Genetic linkage maps represent the order of known molecular genetic markers along a given chromosome for a given species. This provides an insight into the organisation of a plant genome. In comparative genomics, synteny is the preserved order of genes on chromosomes of related species which results from descent from a common ancestor. Comparative mapping is a valuable technique to identify similarities and differences between species and enables the transfer of information from one map to another and assists in the reconstruction of ancestral genomes. This chapter demonstrates the application of online resources to identify candidate genes underlying a QTL, conduct genome comparisons, identify syntenic regions and view comparative genetic maps in grass and Brassica species.
Livsduelighed som pædagogisk mål: En idéhistorisk kritik og et filosofisk alternativ (2016)

Michel Foucault bestræber sig mod afslutningen af sit forfatterskab på at udvikle et alternativ til konkurrencestatens hypernormalisering, og han omtaler både dette alternativ som en frihedens eksistensetik og livsæstetik. En væsentlig del af denne bestræbelse fører Foucault omkring den hellenistiske og romerske psykagogik, der er tænkt som et eksplicit modsvar til dårlig pædagogik. Nemlig ved at fokusere på at fremme det enkelte menneskes indre sjælelige frihed til at følge egne livsmål og udvikle livsparathed. I dag bliver det pædagogiske dannelsesideal om livsduelighed i stigende grad omtalt som et relevant pædagogisk mål, og idealet bliver ofte associeret med det psykologiske begreb resiliens fra den kognitiv-behavioristiske tradition. Teksten skitserer, hvordan den hellenistiske-romerske etik giver en mulighed for at kvalificere idealet om livsduelighed som et specifikt filosofisk pædagogisk mål, der kan udgøre et alternativ til begrebet resiliens, som netop truer med at blive et hypernormalitetsbegreb.
Shear‐Induced Macropore‐Infused Nanocomposite Emulsion Thermosets (2022)

Abstract To create macropore‐infused nanocomposite emulsion thermosets (MINET), a mixing pathway is demonstrated in which a viscous fluid is kinetically trapped by high shear mixing of immiscible liquids, surfactant, and nanoparticles. The MINETs are prepared from common ingredients that are widely employed in industry, including epoxy resin, vegetable oil, epoxidized soybean oil, and different types of nanoparticles such as silica, activated carbon, alumina, and zinc oxide. MINETs prepared by the presented route are processed at ambient conditions and exhibit low shrinkage (&lt;2%). Furthermore, they are suitable to form macro‐ to microscale structures with high precision and various controlled porosity. The interconnected porous architecture of MINET is even preserved in molded micrometer‐scale features and thus ensures mass transport through multiscale structures. In combination with standard microembossing or photolithography, the high throughput microfabrication of microstructured architectures with tunable pore sizes in a wide range (≈100 nm to ≈10 µm) is possible. As one application example, the parallel production of multiplexed electrospray emitters is demonstrated.
Multiple model impedance spectroscopy techniques for testing electrochemical systems (2005)

Rapid battery impedance techniques have become mandatory in most battery management programs. Methods available today use a one-frequency technique at relatively high frequencies 83-90 Hz Huet, F. (1998) for this type of analysis. The results so far demonstrate reasonable accuracy at determining degradation between 0-75% battery capacity Markle, G.J. (1993). However, the same data also indicates a reduced correlation when the capacity of the battery is higher than 80% Noworolski, Z., et al. (2002). According to IEEE 450, any battery below 80% must be replaced. This creates a serious problem since the detection of the replacement boundary is directly in the region where high frequency impedance techniques become least reliable. A possible solution to this problem is to lower the frequency and investigate if better correlation may be attained. This assumption is supported by the literature where Tenno et al. provides experimental evidence for greater correlation at low frequency Tenno, A., et al. (2002). However, this raises a practical dilemma since cells must be tested in reasonable timescales. If several low frequency acquisitions are performed using standard techniques, the timescale for a complete test including modeling calculations would require /spl sim/1 minute per cell. This is approximately 6 times longer then currently available techniques and is not practically feasible. This problem may be resolved by inspecting our initial conditions and assumptions. Physically in combined solid and liquid electrochemical systems, a strong increase in nonlinearity is induced when voltages and currents increase Macdonald, J.R. (1987). However, if we choose the excitation voltage to be less than the thermal voltage, it may be demonstrated that the response will be linear.
Immunologic studies of prostatic cancer using the R3327 rat model. (1978)

We report herein on the destruction by cryosurgery of the Dunning R3327 adenocarcinoma grown in the prostate. Tumors less than 1,000 mm.3 were destroyed by a single freezing procedure within 2 to 4 weeks, whereas tumors greater than 1,000 mm.3 could not be destroyed completely. We also have been able to demonstrate antibody and cellular immune responses to antigens on the R3327 cells. Species, organ and tumor specific antigens were identified by xenogeneic antiserum produced in the rabbit, while major and minor antigens were identified by alloantisera produced in the rat. Tumor antigens were characterized by a variety of in vitro and in vivo immune responses. In addition to the rabbit xenoantisera used in cytotoxicity assays, mixed lymphocyte tumor interaction produced a demonstrable in vitro immune response, lymphocytes from rats immunized with tumor cells were cytotoxic to radiolabeled tumor cells in culture, rats immunized with tumor cells in adjuvant demonstrated protection against subsequent challenge and immunological stimulation of lymph nodes draining the site of tumor cell inoculation was demonstrated by an increase in lymphocyte trapping. Clearing, the R3327 tumor system in the rat is suitable for immunological studies of prostatic cancer.
Querying industrial stream-temporal data: An ontology-based visual approach1 (2017)

An increasing number of sensors are being deployed in business-critical environments, systems, and equipment; and stream a vast amount of data. The operational efficiency and effectiveness of business processes rely on domain experts’ agility in interpreting data into actionable business informatio n. A domain expert has extensive domain knowledge but not necessarily skills and knowledge on databases and formal query languages. Therefore, centralised approaches are often preferred. These require IT experts to translate the information needs of domain experts into extract-transform-load (ETL) processes in order to extract and integrate data and then let domain experts apply predefined analytics. Since such a workflow is too time intensive, heavy-weight and inflexible given the high volume and velocity of data, domain experts need to extract and analyse the data of interest directly. Ontologies, i.e., semantically rich conceptual domain models, present an intelligible solution by describing the domain of interest on a higher level of abstraction closer to the reality. Moreover, recent ontology-based data access (OBDA) technologies enable end users to formulate their information needs into queries using a set of terms defined in an ontology. Ontological queries could then be translated into SQL or some other database query languages, and executed over the data in its original place and format automatically. To this end, this article reports an ontology-based visual query system (VQS), namely OptiqueVQS, how it is extended for a stream-temporal query language called STARQL, a user experiment with the domain experts at Siemens AG, and STARQL’s query answering performance over a proof of concept implementation for PostgreSQL.
Stimulated Raman spectral microscope using synchronized Er- and Yb-fiber lasers (2014)

We report our development of a stimulated Raman scattering (SRS) spectral microscope employing synchronized fiber-laser (FL)-based pulse sources, which generate both pump and Stokes pulses. The pump pulses are obtained through the second-harmonic generation of Er-FL pulses. The high-frequency noise in the photocurrent of the pump pulses is successfully suppressed to the shot-noise limit by the collinear balanced detection (CBD) technique using a compact fiber delay line. Fast wavelength-tunable Stokes pulses are generated through the spectral filtering of broadband Yb-FL pulses and post amplification. To achieve a wide wavelength tunability, we introduce a double-pass spectral filter and confirm that the wavelength tunability can be extended to ∼280 cm −1 , while the wavelength tunability with a single-pass spectral filter is ∼190 cm −1 . The spectral filter is also used to compensate for the group delay dispersion (GDD) of Stokes pulses, which is induced by fiber amplifiers. We show that the negative dispersion can be introduced to the pulses simply by shifting the position of the diffraction grating in the spectral filter. Although the wavelength tunability is slightly decreased to 230 cm −1 after the compensation, it is sufficient for covering the CH-stretching vibration region. The SRS imaging and microspectroscopy of polymer beads and HeLa cells are successfully demonstrated.
Large Eddy Simulation of Primary Diesel Spray Atomization (2004)

&lt;div class="htmlview paragraph"&gt;One of the major problems in the CFD simulation of Diesel sprays is the incomplete and inadequate specification of initial conditions for the spray droplets. This is mainly a consequence of lack of understanding of the atomization process, which has inhibited the development of sufficiently general and accurate models for use in engine combustion simulations. In this paper a novel CFD approach, combining multiphase volume-of-fluid (VOF) and large eddy simulation (LES) methodologies, is used to perform quasi-direct transient fully three dimensional calculations of the atomization of a high-pressure diesel jet, providing detailed information on the processes and structures in the near nozzle region. The methodology allows separate examination of diverse influences on the breakup process and is expected in due course to provide a detailed picture of the mechanisms that govern the spray formation. It will therefore be a powerful tool for assisting in the development of accurate atomization models for practical applications. Our investigations so far have focused on the performance and initial validation of the methodology, in the absence of cavitation.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The performance studies described herein examined the effects of solution domain extent, mesh resolution and inlet conditions. All are found to have a significant but understandable influences on the spray statistics, including the atomized and unatomized liquid mass distributions, the liquid surface area evolution and the droplet shape and size distributions. The calculated liquid core length and spray angles are found to compare reasonably well with published experimental values. The general morphology of the spray and liquid core are also investigated, including some details of specific flow features believed to be involved in the atomization process. Overall, the simulation suggests that for the conditions investigated, the breakup initialization is fundamentally three dimensional and strongly coupled to the upstream liquid turbulence generated in the nozzle. The disintegration of the liquid core is found to result from non-linear growth of selected initial perturbations through the Kelvin-Helmholtz instability mechanism, which is driven by the inter-phase aerodynamic interaction. Thus the methodology appears to provide a computational link between flow in the injector nozzle and primary break-up of the diesel jet.&lt;/div&gt;
Monoclonal antibodies to enterobacterial common antigen and to Escherichia coli lipopolysaccharide outer core: demonstration of an antigenic determinant shared by enterobacterial common antigen and E. coli K5 capsular polysaccharide (1985)

We established hybridoma cell lines producing monoclonal antibodies against enterobacterial common antigen (ECA) and a substructure of the outer core of different Escherichia coli lipopolysaccharides (LPSs). Anti-ECA antibodies 865 and 898 reacted with ECA in extracts of heated E. coli and with ECA-bound R1 and R4 core-containing LPS preparations, as well as with a purified sample of ECA from Salmonella montevideo. Antibody 865, but not antibody 898, cross-reacted with K5 capsular polysaccharide, suggesting that 4-linked alpha-N-acetylglucosamine is part of an antigenic determinant shared by both K5 polysaccharide and ECA. Anti-LPS antibody 786 recognized an outer core structure common to E. coli K-12, B, R2, and R4 core type LPS, but not to R1 and R3 core type LPS. Its most probable target is the trisaccharide sequence Hexp(1----2)-alpha-D -Glcp(1----3) alpha-D-Glcp----(Hepp) (where Hex is hexose, p is phosphate, Glc is glucose, and Hep is heptose), the first glucose being the immunodominant moiety. These monoclonal antibodies may be used not only for the detection of ECA, K5, and LPS core structures but also for analysis of the molecular forms resolved on polyacrylamide gels (banding patterns) of both ECA and LPS, independently of one another.