gebhart/patrepeval huggingface dataset:
Functional Reconstitution of Human FcRn in Madin-Darby Canine Kidney Cells Requires Co-expressed Human β2-Microglobulin (2002)

The major histocompatibility complex class I-related neonatal Fc receptor, FcRn, assembles as a heterodimer consisting of a heavy chain and beta(2)-microglobulin (beta(2)m), which is essential for FcRn function. We observed that, in Madin-Darby canine kidney (MDCK) cells, the function of human FcRn in mediating the bidirectional transport of IgG was significantly increased upon co-expression of the human isoform of beta(2)m. In MDCK cells, the presence of human beta(2)m endowed upon human FcRn an enhanced ability to exit the endoplasmic reticulum and acquire mature carbohydrate side-chain modifications at steady state, a faster kinetics of maturation, and augmented localization at the cell surface as a mature glycoprotein able to bind IgG. Although human FcRn with immature carbohydrate side-chain modifications was capable of exhibiting pH-dependent binding of IgG, only human FcRn with mature carbohydrate side-chain modifications was detected on the cell surface. These results show that human FcRn travels to the cell surface via the normal secretory pathway and that the appropriate expression and function of human FcRn in MDCK cells depends upon the co-expression of human beta(2)m.
Subcube allocation and task migration in hypercube multiprocessors (1990)

Two important issues in managing processors in a hypercube are addressed: subcube allocation and task migration to eliminate the system fragmentation caused by allocation and deallocation of subcubes. It is proven that the subcube allocation strategy using a binary reflected Gray code (BRGC), called the GC strategy, possesses the best subcube recognition ability among all strategies using sequential searches. A binary code (BC) is defined as the binary representation of a nonnegative integer, and an extended binary code (EBC) is obtained by permutating the bits of a BC. Similarly, an extended Gray code (EGC) is obtained from a BRGC. The subcube recognition ability of an allocation strategy using multiple EBCs is analyzed and compared to that using multiple EGCs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Lipophilic Metal−Salicylideneimine−Crown Ether Hybrids - Ditopic Carriers in the Facilitated Transport of Amphiphilic Molecules Across Bulk Liquid Membranes (2001)

The crown ether-functionalized MnIII salicylaldimine complexes manganese(III) 4,5-bis(3,5-di-tert-butylsalicylideneimine)benzo-18-crown-6-X [X = Cl−, I−, CH3COO−, (CH3)3CCOO−, B(Ph)4−] have recently been synthesized and studied as effective ditopic transport carriers of hydrophobic amino acids and neurotransmitters through CHCl3 bulk liquid membranes (BLMs). A detailed analysis of the BLM transport of tryptophan and serotonin with these complexes, along with various derivatives, shows the ditopic nature of the mechanism of transport and reveals the importance of the role of both the crown ether function and the metal center. Kinetic data on the BLM transport of tryptophan follow Michaelis−Menten behavior with Km = 25 mM and Vm = 6.75 × 10−3h−1. Variable temperature studies on the rate of transport of tryptophan (and serotonin) were conducted. From Arrhenius plots, the activation energies, Ea, and pre-exponential factors, A, were determined to be 20 ± 1 (17 ± 5) kJ mol−1 and 8200 (947) M−1h−1, respectively. From these parameters, values for the thermodynamic activation energies, ΔG‡, ΔH‡, and ΔS‡ were calculated to be 26 ± 4 (32 ± 1) kJ mol−1, 17 ± 1 (14 ± 5) kJ mol−1, and −30 ± 9 (−60 ± 14) J K−1 mol−1, respectively. Similar studies with serotonin are reported.
Identification and gene expression profiling of the Pum1 and Pum2 members of the Pumilio family in the chicken (2007)

Members of the Pumilio (Pum) family of RNA-binding proteins act as translational repressors and are required for germ cell development and asymmetric division. We identified the chicken Pum1 and Pum2 genes and analyzed their expression patterns in various tissues. Comparative sequence analysis of the Pum1 and Pum2 proteins from the drosophila, chicken, mouse, and human revealed a high degree of evolutionary conservation in terms of the levels of homology of the peptide sequences and the structure of Pumilio homology domain (PUM-HD), C-terminal RNA-binding domain, with similar spacing between the adjacent Pum eight tandem repeats. In addition, phylogenetic patterns of pumilio family showed that Pum 1 and 2 of chicken are more closely related to those of mouse and human than other species and Pum1 is more conserved than Pum2. Using real-time RT-PCR, the expression levels of the Pum1 and Pum2 genes were found to be highest in hatched female gonads, and high-level expression of Pum2 was detected in 12-day and hatched gonads among the various chicken embryonic tissues tested. In adult tissues, the expression levels of Pum1 and Pum2 were expressed at higher levels in the testis and muscle than in any other tissue. The characteristics of the tissue-specific expression of Pum genes suggest that Pum1 and Pum2 have effects crucially in particular stage during development of chicken gonads depending on sexual maturation.
ChemInform Abstract: Heck, Suzuki and Sonogashira Cross‐Coupling Reactions Using ppm Level of SBA‐16 Supported Pd‐Complex. (2015)

Abstract The catalyst is recoverable and reusable for five cycles without significant loss of activity.
Finding Non-Polynomial Positive Invariants and Lyapunov Functions for Polynomial Systems through Darboux Polynomials (2014)

International audience
Laboratory studies on the praying mantisOrthodera ministralis(Mantodea: Mantidae) (1984)

Aspects of the biology of the mantid Orthodera ministralis (Fabricius) were studied in the laboratory. Oothecae contained an average of 34 eggs per case, with a mean length of 11.3 mm. Oothecal and nymphal development was temperature dependent, and 6 instars were found. Adult female mantids consumed up to 6 large blowflies (Calliphoridae) in 6 hours, with a mean of 2.5 flies per female, and up to 26 Musca domestica (L.) in 3 hours, with a mean of 17.5 flies per female. Cannibalism among 3rd and 4th instar nymphs was highly significantly (p<0.01) reduced by the presence of Drosophila melanogaster (Meig.), and highly significantly increased (p<0.01) at the higher mantid density. Cannibalism by 4th instar nymphs on 1st instar nymphs was very highly significantly (p<0.001) reduced by the presence of D. melanogaster and a complex environment, and very highly significantly (p< 0.001) increased by a higher 1st instar density.
Oxidation of imines to nitrones by the permanganate ion (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of imines to nitrones by the permanganate ionDorthe Christensen and Karl Anker JoergensenCite this: J. Org. Chem. 1989, 54, 1, 126–131Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/jo00262a029https://doi.org/10.1021/jo00262a029research-articleACS PublicationsRequest reuse permissionsArticle Views909Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modeling the course of Alzheimer's disease to improve clinical trials: symposium report (2013)

In a symposium held at the Clinical Trials in Alzheimer's Disease conference in Monte Carlo, Monaco (29 to 31 October 2012) three different, not mutually exclusive approaches to improve and facilitate clinical trials with anti-dementia drugs were presented and discussed. All three approaches are summarized in this manuscript. Core suggestions are: stratification of trial participants at the outset of studies, using cognitive and disease-course characteristics available at baseline; creating new composite cognitive scores for optimizing responsiveness to decline in early and very early Alzheimer's disease; and replacing some of the conventional long-term placebo-controlled trials in advanced stages of drug development, using the placebo group simulation approach. Future efforts should focus on incorporating, where appropriate, the suggestions provided at the symposium into clinical trials now being planned.
Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes (2019)

Multidrug resistant (MDR) Acinetobacter baumannii poses a growing threat to global health. Research on Acinetobacter pathogenesis has primarily focused on pneumonia and bloodstream infections, even though one in five A. baumannii strains are isolated from urinary sites. In this study, we highlight the role of A. baumannii as a uropathogen. We develop the first A. baumannii catheter-associated urinary tract infection (CAUTI) murine model using UPAB1, a recent MDR urinary isolate. UPAB1 carries the plasmid pAB5, a member of the family of large conjugative plasmids that represses the type VI secretion system (T6SS) in multiple Acinetobacter strains. pAB5 confers niche specificity, as its carriage improves UPAB1 survival in a CAUTI model and decreases virulence in a pneumonia model. Comparative proteomic and transcriptomic analyses show that pAB5 regulates the expression of multiple chromosomally-encoded virulence factors besides T6SS. Our results demonstrate that plasmids can impact bacterial infections by controlling the expression of chromosomal genes.
Comparison between an ASK Event-Based Demodulation and a Digital IQ Demodulation (2021)

This paper presents a comparison between two ASK demodulation techniques. The first one is a digital implementation of a traditional IQ demodulation, while the second is a novel digital demodulation algorithm connected to an EB-ADC (Event-Based ADC) for minimizing the number of processed events. The EB-ADC has been designed using a reduced LCSS (Level Crossing Sample Scheme) with only 2 levels, connected to two strong-arm comparators for the digitalization process. Electrical simulations were used to characterize these comparators for integrating them in a full digital SystemVerilog (SV) simulation. An adaptation of python's library has been modeled in SV for simulating the RF input signal and its amplitude noise. This implemented algorithm benefits from the measurement of the time elapsed between two adjacent events improving the demodulator performance and noise resiliency, reaching, for instance, a BER=3.33·10-7 for a modulation index (MI) of 10
Supplementary Figure 3 from Smoking Attenuates Transforming Growth Factor-β–Mediated Tumor Suppression Function through Downregulation of Smad3 in Lung Cancer (2023)

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Bragg gratings in the germanium-doped concentric rings of an Yb3+- doped core solid photonic bandgap fibre (2010)

We demonstrate the inscription of Bragg gratings in each of the three, concentric, germanium-doped rings of an ytterbium-doped-core photonic-bandgap fibre. These rings can support several modes and the effective indices of these modes are derived experimentally from the grating peaks. They are found to be in excellent agreement with numerical simulation.
Visualizing the Topical Structure of the Medical Sciences: A Self-Organizing Map Approach (2013)

Study results demonstrate that it is possible to transform a very large document corpus into a map that is visually engaging and conceptually stimulating to subject experts from both inside and outside of the particular knowledge domain. The challenges of dealing with a truly large corpus come to the fore and require embracing parallelization and use of supercomputing resources to solve otherwise intractable computational tasks. Among the envisaged future efforts are the creation of a highly interactive interface and the elaboration of the notion of this map of medicine acting as a base map, onto which other knowledge artifacts could be overlaid.
ENVIRONMENTAL MANAGEMENT SYSTEMS: A NATURAL HOME FOR TRAVEL PLANS? (2001)

Available from British Library Document Supply Centre- DSC:DXN058669 / BLDSC - British Library Document Supply Centre
Irradiation Induced Defects in YBa2Cu3O 7-δ Coated Conductors (2016)

Journal Article Irradiation Induced Defects in YBa2Cu3O 7- δ Coated Conductors Get access Huaping Sheng, Huaping Sheng Center for Nanoscale Materials, Argonne National Laboratory, Argonne, IL Search for other works by this author on: Oxford Academic Google Scholar Jianguo Wen, Jianguo Wen Center for Nanoscale Materials, Argonne National Laboratory, Argonne, IL Search for other works by this author on: Oxford Academic Google Scholar Lifen Wang, Lifen Wang Center for Nanoscale Materials, Argonne National Laboratory, Argonne, IL Search for other works by this author on: Oxford Academic Google Scholar Dean J Miller, Dean J Miller Center for Nanoscale Materials, Argonne National Laboratory, Argonne, IL Search for other works by this author on: Oxford Academic Google Scholar M Leroux, M Leroux Materials Science Division, Argonne National Laboratory, Argonne, IL Search for other works by this author on: Oxford Academic Google Scholar U Welp, U Welp Materials Science Division, Argonne National Laboratory, Argonne, IL Search for other works by this author on: Oxford Academic Google Scholar W-K Kwok, W-K Kwok Materials Science Division, Argonne National Laboratory, Argonne, IL Search for other works by this author on: Oxford Academic Google Scholar M W Rupich, M W Rupich American Superconductor Corporation, 64 Jackson Rd, Devens, MA Search for other works by this author on: Oxford Academic Google Scholar P M Niraula, P M Niraula Department of Physics, Western Michigan University, Kalamazoo, MI Search for other works by this author on: Oxford Academic Google Scholar A Kayani, A Kayani Department of Physics, Western Michigan University, Kalamazoo, MI Search for other works by this author on: Oxford Academic Google Scholar ... Show more S Eley, S Eley Materials Physics and Applications Division and Condensed Matter and Magnet Science, Los Alamos National Laboratory, Los Alamos, NM Search for other works by this author on: Oxford Academic Google Scholar L Civale L Civale Materials Physics and Applications Division and Condensed Matter and Magnet Science, Los Alamos National Laboratory, Los Alamos, NM Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 22, Issue S3, 1 July 2016, Pages 1492–1493, https://doi.org/10.1017/S1431927616008308 Published: 25 July 2016
Fibrillarin methylates H2A in RNA polymerase I trans-active promoters in Brassica oleracea (2015)

Fibrillarin is a well conserved methyltransferase involved in several if not all of the more than 100 methylations sites in rRNA which are essential for proper ribosome function. It is mainly localized in the nucleoli and Cajal bodies inside the cell nucleus where it exerts most of its functions. In plants, fibrillarin binds directly the guide RNA together with Nop56, Nop58, and 15.5ka proteins to form a snoRNP complex that selects the sites to be methylated in pre-processing of ribosomal RNA. Recently, the yeast counterpart NOP1 was found to methylate histone H2A in the nucleolar regions. Here we show that plant fibrillarin can also methylate histone H2A. In Brassica floral meristem cells the methylated histone H2A is mainly localized in the nucleolus but unlike yeast or human cells it also localize in the periphery of the nucleus. In specialized transport cells the pattern is altered and it exhibits a more diffuse staining in the nucleus for methylated histone H2A as well as for fibrillarin. Here we also show that plant fibrillarin is capable of interacting with H2A and carry out its methylation in the rDNA promoter.
Combining haptic and braille technologies (1996)

This article describes design issues for a bi-dimensional single cell braille display, called Pantobraille, combining a standard braille cell with a force feedback device developed as part of the Cffl's PC-Access project. The Pantobraille, with a 10xl6cm workspace, allows the user to place the pointer on a graphical interface, to perceive forms and textures using the sense of touch, and to read braille text on a bi-dimensional page. In order to determine the usability of such a device and to have a better understanding of the issues that may arise when manipulating it for actual interactive tasks, two visually handicapped persons were asked to use the device to follow reading patterns with one or two hands. Reading performance and comfort with the Pantobraille remain inferior to standard braille displays but significant improvments were observed while performing the complementary pointing and reading tasks using both hands.
Expression and characterization of an inositol 1,4,5-trisphosphate binding domain of phosphatidylinositol-specific phospholipase C-delta 1. (1994)

It was previously found that the 85-kDa protein purified from rat brain using an inositol 1,4,5-trisphosphate (Ins(1,4,5)P3)-immobilized matrix was the delta 1 isoform of phosphatidylinositol-specific phospholipase C (PLC). We expressed rat PLC-delta 1 in Escherichia coli as a fusion protein with glutathione S-transferase, and found that the bacterial lysate shows a significant amount of Ins(1,4,5)P3 binding. The lysate was applied to Ins(1,4,5)P3-immobilized column chromatography and the eluate with 2 M NaCl solution containing only a 100-kDa protein showed high Ins(1,4,5)P3 binding. The lysate was also purified to near homogeneity using a glutathione-Sepharose 4B affinity system. Bacterially-expressed enzyme thus purified showed essentially the same inositol phosphate binding characteristics as the brain-derived enzyme. PLC-delta 1 consists of the amino-terminal nonconserved region and two well-conserved regions among isozymes, designated as X and Y, which are thought to constitute a catalytic core of the enzyme. Using a combination of deletion mutants and proteolytic products of the enzyme, we were able to locate an Ins(1,4,5)P3 binding domain in the molecule. Deletion of 223 residues from the amino terminus completely abolished the binding activity, while deletion of X region only partially inhibited the binding and deletion of Y region did not affect the binding. A 76-kDa proteolytic product of the expressed PLC-delta 1 which lacked 60 amino acids at the amino terminus showed a minimal Ins(1,4,5)P3 binding activity. A peptide consists of 14 amino acids corresponding to residues 30-43 of PLC-delta 1, which contains 6 basic amino acids, binds to an Ins(1,4,5)P3-immobilized matrix. Moreover, Ins(1,4,5)P3 binding was blocked by phospholipid vesicles containing phosphatidylinositol 4,5-bisphosphate. These results, taken together, indicate that the amino-terminal domain of PLC-delta 1 is important for the binding of both Ins(1,4,5)P3 and phosphatidylinositol 4,5-bisphosphate.
Engineered feature used to enhance gardening at a 3800-year-old site on the Pacific Northwest Coast (2016)

Humans use a variety of deliberate means to modify biologically rich environs in pursuit of resource stability and predictability. Empirical evidence suggests that ancient hunter-gatherer populations engineered ecological niches to enhance the productivity and availability of economically significant resources. An archaeological excavation of a 3800-year-old wetland garden in British Columbia, Canada, provides the first direct evidence of an engineered feature designed to facilitate wild plant food production among mid-to-late Holocene era complex fisher-hunter-gatherers of the Northwest Coast. This finding provides an example of environmental, economic, and sociopolitical coevolutionary relationships that are triggered when humans manipulate niche environs.
Reduction of Relapse after Unrelated Donor Stem Cell Transplantation by KIR-Based Graft Selection (2017)

Besides donor T cells, natural killer (NK) cells are considered to have a major role in preventing relapse after allogeneic hematopoietic stem cell transplantation (HSCT). After T-cell-depleted haploidentical HSCT, a strong NK alloreactivity has been described. These effects have been attributed to killer-cell immunoglobulin-like receptors (KIR). Abundant reports suggest a major role of KIR not only on outcome after haploidentical HSCT but also in the unrelated donor setting. In this review, we give a brief overview of the mechanism of NK cell activation, nomenclature of KIR haplotypes, human leukocyte antigen (HLA) groups, and distinct models for prediction of NK cell alloreactivity. It can be concluded that KIR-ligand mismatch seems to provoke adverse effects in unrelated donor HSCT with reduced overall survival and increased risk for high-grade acute graft-versus-host disease. The presence of activating KIR, as seen in KIR haplotype B, as well as the patient's HLA C1/x haplotype might reduce relapse in myeloid malignancies.
CORDIC instruction set extensions for matrix decompositions on Software Defined Radio processors (2009)

Software Defined Radio (SDR) is favored by the wireless industry as the platform of choice for implementing physical layers of wireless protocols due to its significant benefits of reduced development costs and accelerated time-to-market. However, to attain high spectral efficiency, emerging wireless protocols use increasingly complex two-dimensional techniques that are extremely expensive to implement using conventional Digital Signal Processor (DSP) instruction sets. In this paper, we present COordinate Rotation DIgital Computer (CORDIC) instruction set extensions that speed up the QR Decomposition (QRD) and Singular Value Decomposition (SVD) of complex matrices that are used in several important communication algorithms. The performance benefits are evaluated on the Sandbridge Sandblaster SB3000 low-power, multithreaded SDR processor. The proposed instructions provide significant performance improvements with little hardware overhead, while improving the accuracy of the wireless algorithms under investigation.
Evaluation of changes in cardiac output from the electrical impedance waveform in the forearm (2007)

We tested the validity of regional impedance cardiography (RIC) for measuring changes in both cardiac output and stroke volume by comparing the values with a 2D ultrasound technique in response to the breath-hold manipulation. Among 13 subjects, changes in the maximum amplitude of the regional impedance waveform from the forearm conformed to those in stroke volume (r = 0.86, p < 0.001) and cardiac output (r = 0.76, p < 0.003) measured with the ultrasound technique in baseline and immediately after a 30 s breath-hold maneuver. We also found that the per cent change in cardiac output (r = 0.73, p < 0.005) and the per cent change in stroke volume (r = 0.84, p < 0.0003) by the echocardiography were both positively correlated with the per cent change in the peak impedance amplitude. In addition, both the change and the per cent change in the mean area under the impedance curve were consistent with those in the stroke volume, respectively. Accordingly, the regional electrical impedance waveform from lower limbs may be helpful in providing a non-invasive and continuous assessment of left ventricular output, especially during cardiac procedures.