gebhart/patrepeval huggingface dataset:
A Recombinant Antibody to EphA3 with Pro-Apoptotic and Enhanced ADCC Activity Against Various Hematologic Malignancies Shows Selective Inhibition of Colony Formation From Long-Term Culture-Initiating Cells (LTC-ICs) In Primary Leukemia Samples (2010)

Abstract Abstract 2897 EphA3 is a receptor tyrosine kinase expressed at high level on the surface of some solid tumors and certain leukemias. KB004 is a high-affinity non-fucosylated, recombinant antibody developed by KaloBios derived from a mouse monoclonal anti-EphA3 antibody using Antibody Humaneering™ Technology. The antibody binds EphA3 from human and cynomolgus macaque with equivalent affinity (610 pM for human and 570 pM for cynomolgus as determined by surface plasmon resonance (spr) analysis) making the latter a relevant toxicology species. KB004 has a direct pro-apoptotic effect on EphA3-positive cells and a induces potent antibody-dependent cellular cytotoxicity (ADCC) activity mediated by CD16-expressing effector cells. The non-fucosylated antibody has enhanced affinity for both human and cynomolgus CD16a. The affinity of KB004 for cynomolgus CD16a (7.2 nM, determined by spr analysis) was comparable to the affinity for the high-affinity variant of CD16a from humans (6.6 nM), indicating that KB004 has similar potential for ADCC in cynomolgus macaques. We first demonstrated cell-surface expression of EphA3 by flow cytometry in approximately 50% of primary human leukemia cells. Here we extend the analysis to multiple myeloma (MM) in which 3/5 patient samples show EphA3 expression. EphA3 expression was confirmed in a panel of chronic myeloid leukemia (CML) samples [n=14] and in acute myeloid leukemia (AML) [n=40] in which EphA3+ cells were identified in each French American British (FAB) classification sub-type except M0, for which only two samples were studied. CD123-positive leukemia stem cells (CD34+ CD38− CD123+) also displayed surface expression of EphA3. KB004 induced apoptosis in EphA3+ primary cells from each of the diseases analyzed, including imatinib-sensitive and resistant CML, with no activity in EphA3-negative specimens, including normal CD34+ bone marrow cells. KB004 inhibited myeloid leukemia colony formation (CFU-L) from primary AML samples in methylcellulose colony assays without affecting normal hematopoietic colony recovery and also showed dose-dependent inhibition of long-term culture-initiating cells (LTC-IC) from AML stem cells. EphA3 expression was not detected on primary human CD34+ bone marrow cells from healthy individuals. These data support the development of an anti-EphA3 antibody for the treatment of hematologic malignancies. The selective activity against leukemic stem cells supports a novel strategy for therapeutic targeting of leukemia-initiating cells. Disclosures: No relevant conflicts of interest to declare.
Television observations of Mercury by Mariner 10 (1974)

The morphology and optical properties of the surface of Mercury resemble those of the Moon in remarkable detail, recording a very similar sequence of events; chemical and mineralogical similarity of the outer layers is implied. Mercury is probably a differentiated planet with an iron-rich core. Differentiation is inferred to have occurred very early. No evidence of atmospheric modification of any landform is found. Large-scale scarps and ridges unlike lunar or Martian features may reflect a unique period of planetary compression near the end of heavy bombardment, perhaps related to contraction of the core.
Growth Failure Associated with the Use of High Dose Prozac (Fluoxetine Hydrochloride) in a Patient with Type 1 Diabetes Mellitus (1999)

Article Growth Failure Associated with the Use of High Dose Prozac (Fluoxetine Hydrochloride) in a Patient with Type 1 Diabetes Mellitus was published on May 1, 1999 in the journal Journal of Pediatric Endocrinology and Metabolism (volume 12, issue 3).
Genome Sequences of Microviruses Associated with Coptotermes formosanus (2019)

Termites have a unique ability to effectively digest lignocellulose with the help of mutualistic symbionts. While gut bacteria and protozoa have been relatively well characterized in termites, the virome remains largely unexplored. Here, we report two genomes of microviruses (termite-associated microvirus-1 [TaMV-1] and termite-associated microvirus-2 [TaMV-2]) associated with the gut of <i>Coptotermes formosanus</i>.
A Genetic Algorithm to Filter SNPs for SNP Association Study (2012)

Recent advances in human and medical genetics have made it widely accepted that complex diseases are speculated to be caused by multiple genetic variants, their interactive effects, and/or their interactions with environment factors. To find causative factors from genome-wide single-nucleotide polymorphisms (SNPs), SNP filtering is necessary and the key process for follow-up scientific-oriented causative factor discovery and causative interaction modeling. This paper proposes a novel genetic algorithm for SNP filtering. By introducing SNP frequency and using genetic algorithm, experiments on famous trunk data for feature selection, on SNP data for SNP filtering and on real AMD SNP dataset, indicate that the proposed algorithm is potential for both feature selection and feature filtering for genome-wide scale datasets.
Geologically-Consistent Rock Physics Modeling for Sandstones – Modulus-Based Prediction of In Situ Elastic Properties (2004)

F045 GEOLOGICALLY-CONSISTENT ROCK PHYSICS MODELING FOR SANDSTONES: MODULUS- BASED PREDICTION OF IN SITU ELASTIC PROPERTIES Summary 1 In this paper we describe a new model capable of robust predictions of elastic properties (Vp and Vs) for consolidated sandstones. The model is based on a new set of high quality laboratory velocity measurements each supported by detailed petrologic evaluation and rigorous evaluation of rock and fluid acoustic properties from well data. We develop relationships between porosity and dry rock moduli (bulk and shear) using laboratory velocity data for a geologically diverse set of quartzdominated lithified sediments. The model performs well in
Surface plasmon resonance analysis to evaluate the importance of heparin sulfate groups' binding with human aFGF and bFGF. (2003)

Human acidic and basic fibroblast growth factors (aFGF and bFGF) are classic and well characterized members of the heparin-binding growth factor family. Heparin is generally thought to play an extremely important role in regulating aFGF and bFGF bioactivities through its strong binding with them. In order to unravel the mechanism of the interactions between heparin and FGFs, and evaluate the importance of heparin sulfate groups' binding with FGFs, surface plasmon resonance analyses were performed using IAsys Cuvettes System. Heparin and its regioselectively desulfated derivatives were immobilized on the cuvettes. aFGF and bFGF solutions with different concentrations were pipetted into the cuvettes and the progress of the interaction was monitored in real-time by Windows-based software, yielding kinetic and equilibrium constants for these interactions. In addition, in order to reduce the delicate difference among the cuvettes, inhibition analyses of mixture of FGFs and immobilized native heparin by modified heparins were also done. The data from these two methods were similar, indicating that all sulfate groups at 2-O, 6-O and N- in heparin were required for the binding to aFGF; and that their contribution to the binding was in the order 2-O, N- and 6-O-sulfate group. In contrast, definite contribution of the 6-O-sulfate group to the binding with bFGF was most apparent, while the other two sulfate groups appeared to be necessary in the order 2-O and N-sulfate group. These methods established here can be used for analysing the effect of sulfate groups in heparin on the binding with other human FGF members or other heparin-binding proteins.
Antiherpetic effects of a human alpha interferon analog, IFN-alpha Con1, in hamsters (1986)

The efficacy of a novel consensus form of human alpha interferon designated IFN-alpha Con1 was evaluated against herpesvirus infections in vitro and in vivo. At comparable antiviral concentrations, natural lymphoblastoid IFN, IFN-alpha Con1, the molecular subtype IFN-alpha, and the hybrid IFN-alpha AD(Bgl) obtained by recombinant DNA methods conferred similar protection against herpes simplex virus type 1 and type 2 (HSV-2) infections of human cells in vitro. Whereas 7 X 10(5) U of IFN-alpha AD(Bgl) administered in 7 intraperitoneal (i.p.) doses between -4 and 96 h relative to infection protected 90% of mice from a lethal HSV-2 infection, a similar treatment regimen with IFN-alpha Con1 conferred no protection. Systemic HSV-2 infection of hamsters was rapidly lethal, but a single i.p. treatment with 10(6) U of either IFN-alpha Con1 or IFN-alpha AD(Bgl) was highly effective and protected 90 and 75% of animals, respectively, when given 6 h before infection; treatment with IFN-alpha Con1 protected 45% of animals when administered 10 h after infection. In addition, IFN-alpha Con1 was highly protective against acute cervicovaginal HSV-2 infection of hamsters when administered either in a single i.p. dose of 10(6) U at -6 or 10 h relative to infection or in multiple i.p. doses of 10(6) U between -6 and 120 h relative to infection. Protection was manifested by a delay in the onset of and a reduction in duration of infection, a reduction in the number of positive cervicovaginal infections, and an increase in the survival rate.
Power saving control strategies and their implementation in DC/DC converter for data and telecommunication power supply (2010)

The paper focuses on promising topologies and control strategies to meet strict power saving and efficiency requirements over wide output power range demanded by new regulations and trends in data and telecommunication industry. The optimal control algorithm for phase shifted ZVS DC/DC converter is described implemented in new IC controller. Some practical design recommendations are provided allowing zero voltage switching at all operating conditions. The advantages of suggested control strategy are verified by test results based on 95.3% efficient, 12-V, 660-W output DC/DC converter for server power supply.
Manipulation of Distinct NFκB Proteins Alters Interleukin-1β-induced Human Rheumatoid Synovial Fibroblast Prostaglandin E2 Formation (1996)

Interleukin 1beta (IL-1beta) up-regulates human rheumatoid synovial fibroblast (RSF) 85-kDa phospholipase A2 (PLA2) and mitogen-inducible cyclooxygenase (COX) II. Promoter regions for these genes contain a motif that closely resembles the "classic" NFkappaB consensus site. Immunoblot analysis identified NFkappaB1 (p50), RelA (p65), and c-Rel in RSF. Upon IL-1beta-stimulation, p65 and c-Rel but not p50 protein levels were reduced suggesting nuclear translocation. IL-1beta-induced RSF nuclear extracts contained a p65-containing complex, which bound to the classical NFkappaB consensus motif. An NFkappaB classical oligonucleotide decoy produced a concentration-dependent decrease in IL-1-stimulated PGE2 production (IC50 = approximately 2 microM), indicating a role of NFkappaB. Utilization of antisense technology showed that p65 but not p50 or c-Rel mediated IL-1beta-stimulated PGE2 formation. Treated RSF could not transcribe COX II or 85-kDa PLA2 mRNA, which reduced their respective proteins. Interestingly, stimulated IL-8 production was not inhibited by the classical NFkappaB decoy but was reduced by treatment with antisense to both p65 and c-Rel supporting preferential binding of c-Rel-p65 to the "alternative" IL-8 kappaB motif. Taken together, these data provide the first direct evidence for a role of p65 in COX II and 85-kDa PLA2 gene induction and support the IL-1 activation and participation of distinct NFkappaB protein dimers in RSF prostanoid and IL-8 formation.
Robust joint optimization of MIMO interfering relay channels with imperfect CSI (2011)

In this paper we deal with the problem of the joint optimization of the precoders, equalizers and relay beamformer of a multiple-input multiple-output interfering relay channel. This network can be regarded az a generalized model for both one-way and two-way relay channels with/without direct interfering links. Unlike the conventional design procedures, we assume that the Channel State Information (CSI) is not known perfectly. The imperfect CSI is described using the norm bounded error framework. We use a system-wide Sum Mean Square Error (SMSE) based problem formulation which is constrained using the transmit power of the terminals and the relay node. The problem at hand, from a worst-case design perspective, is a multilinear, and hence, a nonconvex problem which is also semi-infinite in its constraints. We use a generalized version of the Peterson's lemma to handle the semi-infiniteness and reduce the original problem to a single Linear Matrix Inequality (LMI). However, this LMI is not convex, and to resolve this issue we propose an iterative algorithm based on the alternating convex search methodology to solve the aforementioned problem. Finally simulation results, i.e., the convergence of the proposed algorithm and the SMSE properties, are included to asses the performance of the proposed algorithm.
Mild autonomous cortisol excess in adrenal incidentalomas - metabolic disease burden and urinary steroid metabolome in 1201 prospectively recruited patients (2017)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Kinetics of Distribution of Microcystin LR in Serum and Liver Cytosol of Mice: An Immunochemical Analysis (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of Distribution of Microcystin LR in Serum and Liver Cytosol of Mice: An Immunochemical AnalysisJia-Rong Lin and Fun S. ChuCite this: J. Agric. Food Chem. 1994, 42, 4, 1035–1040Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/jf00040a038https://doi.org/10.1021/jf00040a038research-articleACS PublicationsRequest reuse permissionsArticle Views111Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Confinement of Molten Metal Using Magnetic Field (2006)

In metal processing, confinement of a molten metal without mechanical contact is of great interest. For example, in a galvanizing process a sink roll, which is set in a zinc bath for changing the moving direction of steel strip, causes troubles such as deteriorating the quality of products and productivity. A new galvanizing process by using a high magnetic field which does not equip the sink roll has been proposed, where the steel strip is inserted from an inlet hole opened on the bottom of the zinc bath. Thus the stable confinement of a molten metal at the hole is crucial technical matter. The confinement of a molten metal and controlling of its flow are also essential for a cold crucible, which is indispensable for precision castings of reactive or high melting point metals like titanium and zirconium alloys. So far alternating and traveling magnetic fields have been applied for confinement of a molten metal, where unstable phenomena in hydrodynamic motion inevitably appear, so that the development of a stable confinement of a molten metal has been strongly desired. The simultaneous imposition of D.C. magnetic field and D.C. electric current is a promising method in respect of energy efficiency, however it easily generates unstable phenomena of the molten metal when a large electric current is imposed under a weak magnetic field.In this paper, a new method of confining a molten metal by applying D.C. magnetic field and D.C. electric current has been proposed. The usefulness of the method, which is promising in industrial applications, has been demonstrated by a model experiment using a molten metal. That is, a molten metal has been more stable confined by using plural pairs of electrodes.
The Alternating Decision Tree Learning Algorithm (1999)

1 INTRODUCTION The AdaBoost algorithm [7, 16] has recently proved to be an important component in practical learning algorithms. Two of the most successful combinations have been boosting decision trees and boosting stumps [6, 1, 13, 8]. Stumps are the simplest special case of decision trees which consist of a single decision node and two prediction leaves. Boosting decision trees learning algorithms, such as CART [2] and C4.5 [14], yields very good classifiers.
Exogenously Triggered, Enzymatic Degradation of Photopolymerized Hydrogels with Polycaprolactone Subunits:  Experimental Observation and Modeling of Mass Loss Behavior (2006)

Degradation plays an important role in the evolution of the extracellular matrix secreted by chondrocytes encapsulated in PEG-based hydrogels. For this study, macromonomers were synthesized by methacrylating both ends of polycaprolactone-b-poly(ethylene glycol)-b-polycaprolactone (PEG-CAP) tri-block copolymers. These divinyl molecules were photopolymerized to form hydrogels with PEG-CAP crosslinks that were subsequently degraded upon exogenous addition of a lipase enzyme. The rate of degradation and subsequent mass loss depends on both the length of the polycaprolactone units and the concentration of enzyme. Control gels that did not receive lipase did not significantly degrade on the time scale of these experiments. A model was developed to predict mass loss using enzyme kinetics and a previously described statistical treatment of bulk network degradation. The model was used to predict mass loss profiles at the specific conditions used, and also to demonstrate the importance of potential changes in reaction rate and enzyme stability on temporal mass loss.
Side-Reading Effects in High-Track-Density Tape Recording (2013)

Aggressive track-density scaling in linear magnetic tape recording has been identified as a key means of sustaining capacity scaling. As the reader width decreases, the relative signal contribution of the written track region outside the lateral extent of the reader increases. We model, analyze and quantify side-reading effects of shielded magneto-resistive read heads reading narrow tracks on perpendicular-oriented tape media. We compare results from extended analytical models with experimental data. An understanding of these effects will be important in designing track misregistration budgets and SNR margins for future operating points of parallel-channel tape recording systems.
Contribution à l’étude théorique de la radiolyse des hydrocarbures liquides : une corrélation entre les rendements en produits radiolytiques et les énergies de liaisons calculées dans des alkanes soumis au rayonnement ionisant (1979)

Le calcul des énergies des liaisons (C — C) et (C — H) d'un certain nombre d'alkanes dans leur état fondamental permet d’interpréter et même de prévoir les rendements en hydrogène G (H2) et en hydrocarbures [math] (C — C) provenant des coupures (C — H) et (C — C) lors de l'irradiation d’un alkane par un rayonnement ionisant.
On modular multilevel converters-based batteries energy storage systems (2015)

This paper presents the analysis of the modular multilevel converter with integrated batteries energy storage and highlights the influence of the active power injected to the grid from the batteries in order to compensate for ac voltage grid asymmetries. The control objective of the converter is to maintain a balance between the phase-leg of the converter and between the arms of each phase. The development of such algorithm relies on the injection of a common ac voltage that oscillates at the fundamental frequency. By redefining the circulating current in order to rebalance the ac grid voltage asymmetries, it is shown through simulation results that the current injected by the batteries is capable of maintaining the cells well balanced.
Malaria Infection. (1898)

Charlotte, N. C., March 7, 1898. <h3>To the Editor:</h3> —In your remarks under the above heading, in the issue of March 5, 1898 (page 561), you make some statements which appear to deserve some qualification, at least from my information and experience on the subject. That there is a form of malaria (the disease) which resists the. therapeutic action of quinin even when in proper dosage by the stomach, rectum and skin, is within the experience of a number of physicians throughout the South. This form of malaria, designated the estivo-autumnal, will not infrequently persist in spite of the exhibition of large and repeated doses of quinin, the patient dying literally saturated with the drug and thoroughly cinchonized. Dr. Osler, the highly gifted and capable authority quoted to support the points of the editorial, has given absolute testimony to the fact that quinin<i>will not</i>remove the crescentic forms from
Faculty Opinions recommendation of Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner. (2019)

Immune cells residing in white adipose tissue have been highlighted as important factors contributing to the pathogenesis of metabolic diseases, but the molecular regulators that drive adipose tissue immune cell remodeling during obesity remain largely unknown. Using index and transcriptional single-cell sorting, we comprehensively map all adipose tissue immune populations in both mice and humans during obesity. We describe a novel and conserved Trem2+ lipid-associated macrophage (LAM) subset and identify markers, spatial localization, origin, and functional pathways associated with these cells. Genetic ablation of Trem2 in mice globally inhibits the downstream molecular LAM program, leading to adipocyte hypertrophy as well as systemic hypercholesterolemia, body fat accumulation, and glucose intolerance. These findings identify Trem2 signaling as a major pathway by which macrophages respond to loss of tissue-level lipid homeostasis, highlighting Trem2 as a key sensor of metabolic pathologies across multiple tissues and a potential therapeutic target in metabolic diseases.Copyright © 2019 Elsevier Inc. All rights reserved. PMID: 31257031 Funding information This work was supported by: NIDDK NIH HHS, United States Grant ID: P30 DK019525 NIDDK NIH HHS, United States Grant ID: R01 DK049780 NIDDK NIH HHS, United States Grant ID: P30 DK056341 Howard Hughes Medical Institute, United States NIDDK NIH HHS, United States Grant ID: P30 DK050306 NIAMS NIH HHS, United States Grant ID: P30 AR069589 NIDDK NIH HHS, United States Grant ID: K08 DK116668 NICHD NIH HHS, United States Grant ID: R25 HD082842 More Less keyboard_arrow_down