gebhart/patrepeval huggingface dataset:
Epimeric 3-vinyl-4-piperdineacetic acids, synthetic precursors of cinchoma and indole alkaloids (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEpimeric 3-vinyl-4-piperdineacetic acids, synthetic precursors of cinchoma and indole alkaloidsM. Uskokovic, C. Reese, H. L. Lee, G. Grethe, and J. GutzwillerCite this: J. Am. Chem. Soc. 1971, 93, 22, 5902–5904Publication Date (Print):November 1, 1971Publication History Published online1 May 2002Published inissue 1 November 1971https://pubs.acs.org/doi/10.1021/ja00751a059https://doi.org/10.1021/ja00751a059research-articleACS PublicationsRequest reuse permissionsArticle Views346Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Autoreactive CD8+ cytotoxic T lymphocytes to major histocompatibility complex class I chain–related gene A in patients with Behçet's disease (2004)

HLA-B51-restricted cytotoxic T lymphocytes autoreactive to MICA may be involved in the pathogenesis of BD.
Whole genome SNP typing to investigate methicillin-resistant Staphylococcus aureus carriage in a health-care provider as the source of multiple surgical site infections (2016)

Whole genome sequence analysis is an ideal method to exclude isolates involved in transmission events and nosocomial outbreaks, and coupling this method with epidemiological data can determine if a transmission event occurred. These methods promise to direct infection control resources more appropriately.
Sensor scheduling with active and image-based sensors for maneuvering targets (2003)

We consider the problem of sensor scheduling between an active and passive sensor in tar- get tracking. The target's dynamics is modelled as a jump Markov linear system. The active sensor yields conventional measurements (position and velocity of the target), the passive sensor is an imager yielding information about the orientation of the target. The scheduling problem is formulated as a stochastic control problem - and a one step ahead scheduling algorithm is presented.
Rickettsia parkeriRickettsiosis, Arizona, USA (2016)

In the United States, all previously reported cases of Rickettsia parkeri rickettsiosis have been linked to transmission by the Gulf Coast tick (Amblyomma maculatum). Here we describe 1 confirmed and 1 probable case of R. parkeri rickettsiosis acquired in a mountainous region of southern Arizona, well beyond the recognized geographic range of A. maculatum ticks. The likely vector for these 2 infections was identified as the Amblyomma triste tick, a Neotropical species only recently recognized in the United States. Identification of R. parkeri rickettsiosis in southern Arizona demonstrates a need for local ecologic and epidemiologic assessments to better understand geographic distribution and define public health risk. Education and outreach aimed at persons recreating or working in this region of southern Arizona would improve awareness and promote prevention of tickborne rickettsioses.
Skeletal Myocytes arethe Source of IL-6 mRNA Expression and Protein Release during Contraction (2004)

1828 PURPOSE: It is now well established that circulating levels of the cytokine interleukin (IL)-6 are elevated during exercise, due to an increase in gene expression within skeletal muscle biopsy specimens and protein release from the contracting limb. However, because skeletal muscle not only contain myocytes but also smooth muscle cells, fibroblasts, endothelial cells and macrophages, speculation still exists as to the source of the IL-6, and the factors that regulate its production. In the present study we aimed to determine whether skeletal muscle cells per se are a source of IL-6 during contraction. METHODS: Muscle biopsy samples were collected from the vastus lateralis muscle of seven healthy males, before (PRE) and after (POST) completing 120 min of continuous exercise. Multiple 10 μm sections were cut and analyzed for IL-6 protein and muscle fiber type detected by immunohistochemistry, IL-6 mRNA content detected by in situ hybridization using a radiolabelled riboprobe for human IL-6, and glycogen content measured by periodic acid schiff (PAS) assay. Fibres were qualitatively categorized according to glycogen content to one of five groups (1–5) with 1 = very low and 5 = very high glycogen. Total fluorescence (PRE vs. POST) and glycogen-dependent fluorescence of IL-6 protein in very low and very high (LOW vs. HIGH) fibres were quantitated using Metamorph software. RESULTS: Total IL-6 protein was elevated (P<0.05) comparing POST with PRE. At PRE, IL-6 protein was evenly distributed across all fibers at low levels, consistent with glycogen distribution. Whereas, at POST, IL-6 protein was greater (P<0.05) in HIGH glycogen fibres, whereas in LOW glycogen fibers IL-6 protein was concentrated at the plasma membrane, indicating protein release from these fibers. IL-6 mRNA was distributed around the periphery of all fibres at PRE. At POST, however, IL-6 mRNA appeared in type 2 fibers, which also had higher (P<0.05) glycogen content. CONCLUSIONS: The data demonstrate that myocytes are the source of IL-6 during contraction. In addition, our data suggest that type 2 fibers predominantly produce IL-6, since it are the type I fibers that are predominantly recruited during this type of contractile activity and any initial recruitment of type 2 fibers may trigger an IL-6 mRNA response. Supported by The National Health and Medical Research Council (MAF 251558)
DEISGN TECHNIQUES FOR AUTOMATIC TRAIN CONTROL (1972)

It is shown how automated control and communication systems presently available provide safe and efficient train operation. System requirements, control implementation, and design techniques are discussed.
Funktionelle Sonografie der Gesichtsmuskulatur mit einseitiger Fazialisparese (2011)

Fragestellung: Erste Berichte, Sonografie zur Darstellung der Gesichtsmuskulatur zu nutzen sind über 20 Jahre alt. Eine quantitative Beschreibung der gesunden Gesichtsmuskulatur und deren pathologische Veränderung durch Fazialisläsion sind aber bisher noch nicht veröffentlicht worden. Die Darstellung mit MRT und CT ist zwar möglich, aufgrund des Aufwandes, der Kosten und der Belastung des Patienten aber nicht für die klinische Routine geeignet. Ob die Sonografie die notwendige Messgenauigkeit und Reproduzierbarkeit liefern kann, um erstmals eine enge Verlaufskontrolle und funktionelle Untersuchungen an Patienten zu ermöglichen, soll diese Studie zeigen.
TUBEFLIGHT POWER-DEMAND TESTS AND INITIAL VALIDATION OF THEORY: 1. ESTIMATED PERFORMANCE OF WHEEL-SUPPORTED VEHICLES TO BE TESTED IN FACILITY T-2. 2. INTERPRETATION OF INITIAL TUBEFLIGHT PROPULSION TEST RESULTS, AND COMPARISON WITH THEORY. 3. TESTS OF WHEEL-SUPPORTED VEHICLES IN THE T-2 FACILITY, (1969)

To permit correlation between the predictions of PB-177 520 and the results of the small-scale model tests that are to be conducted in facility T-2, the power demands of these models are calculated by a procedure that is essentially the same as that of PB-177 520, except for such changes in the analytical model as are suggested or called for by the conditions of the tests. Experimental power demand data are presented for tests of the RPI MK IIc scale-model tubeflight vehicle in test facility T-2. This is done by use of propeller efficiency data generated through testing in the tubeflight wind tunnel, facility T-3. A description of the Mark IIc (wheel-supported) tubeflight vehicle is given. A series of test runs in the T-2 Facility is reported in which the top speed was about 76 feet per second. This result checks very closely with theoretical predictions for this vehicle. (Author)
Zone-Dependent Architecture and Biochemical Composition of Decellularized Porcine Nasal Cartilage Modulate the Activity of Adipose Tissue-Derived Stem Cells in Cartilage Regeneration (2021)

Previous anatomical studies have shown different functional zones in human nasal septal cartilage (NC). These zones differ in respect to histological architecture and biochemical composition. The aim of this study was to investigate the influence of these zones on the fate of stem cells from a regenerative perspective. Therefore, decellularized porcine septal cartilage was prepared and subjected to histological assessment to demonstrate its equivalence to human cartilage. Decellularized porcine NC (DPNC) exposed distinct surfaces depending on two different histological zones: the outer surface (OS), which is equivalent to the superficial zone, and the inner surface (IS), which is equivalent to the central zone. Human adipose tissue-derived stem cells (ASCs) were isolated from the abdominal fat tissue of five female patients and were seeded on the IS and OS of DPNC, respectively. Cell seeding efficiency (CSE), vitality, proliferation, migration, the production of sulfated glycosaminoglycans (sGAG) and chondrogenic differentiation capacity were evaluated by histological staining (DAPI, Phalloidin, Live-Dead), biochemical assays (alamarBlue®, PicoGreen®, DMMB) and the quantification of gene expression (qPCR). Results show that cell vitality and CSE were not influenced by DPNC zones. ASCs, however, showed a significantly higher proliferation and elevated expression of early chondrogenic differentiation, as well as fibrocartilage markers, on the OS. On the contrary, there was a significantly higher upregulation of hypertrophy marker MMP13 (p &lt; 0.0001) and GAG production (p = 0.0105) on the IS, whereas cell invasion into the three-dimensional DPNC was higher in comparison to the OS. We conclude that the zonal-dependent distinct architecture and composition of NC modulates activities of ASCs seeded on DPNC. These findings might be used for engineering of cartilage substitutes needed in facial reconstructive surgery that yield an equivalent histological and functional structure, such as native NC.
Software Faults Diagnosis in Complex OTS Based Safety Critical Systems (2008)

This work addresses the problem of software fault diagnosis in complex safety critical software systems. The transient manifestations of software faults represent a challenging issue since they hamper a complete knowledge of the system fault model at design/development time. By taking into account existing diagnosis techniques, the paper proposes a novel diagnosis approach, which combines the detection and location processes. More specifically, detection and location modules have been designed to deal with partial knowledge about the system fault model. To this aim, they are tuned during system execution in order to improve diagnosis during system lifetime. A diagnosis engine has been realized to diagnose software faults in a real world middleware platform for safety critical applications. Preliminary experimental campaigns have been conducted to evaluate the proposed approach.
AAA-ATPase p97 suppresses apoptotic and autophagy-associated cell death in rheumatoid arthritis synovial fibroblasts (2016)

Valosin containing protein (p97) is a chaperone implicated in a large number of biological processes including endoplasmic reticulum (ER)-associated protein degradation and autophagy. Silencing of p97 in rheumatoid arthritis (RA) synovial fibroblasts (RASFs) increased the amount of polyubiquitinated proteins, whereas silencing of its interaction partner histone deacetylase 6 (HDAC6) had no effect. Furthermore, silencing of p97 in RASFs increased not only rates of apoptotic cell death induced by TRAIL but also induced an autophagy-associated cell death during ER stress that was accompanied by the formation of polyubiquitinated protein aggregates and large vacuoles. Finally, we demonstrated an anti-arthritic effect of siRNAs targeting p97 in collagen-induced arthritis in rats. Our data indicate that p97 may be a new potential target in the treatment of RA.
Sonic hedgehog signalling from foregut endoderm patterns the avian nasal capsule (2008)

Morphogenesis of the facial skeleton depends on inductive interactions between cephalic neural crest cells and cephalic epithelia, including the foregut endoderm. We show that Shh expression in the most rostral zone of the endoderm, endoderm zone I (EZ-I), is necessary to induce the formation of the ventral component of the avian nasal capsule: the mesethmoid cartilage. Surgical removal of EZ-I specifically prevented mesethmoid formation, whereas grafting a supernumerary EZ-I resulted in an ectopic mesethmoid. EZ-I ablation was rescued by Shh-loaded beads, whereas inhibition of Shh signalling suppressed mesethmoid formation. This interaction between the endoderm and cephalic neural crest cells was reproduced in vitro, as evidenced by Gli1 induction. Our work bolsters the hypothesis that early endodermal regionalisation provides the blueprint for facial morphogenesis and that its disruption might cause foetal craniofacial defects, including those of the nasal region.
ChemInform Abstract: Photoluminescence of Tellurium(IV) Chloride Complexes in Solution. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effect of polysaccharide fraction from oyster mushroom (Pleurotus ostreatus) on physicochemical and antioxidative properties of acid casein model processed cheese (2022)

The effect of polysaccharide fraction from oyster mushroom (POM) on texture, rheological and melting properties, density, water activity, colour, and antioxidative properties of acid casein model processed cheese was investigated. The samples were tested after 24 h and 21 days of cold storage. The hardness of cheeses with POM (0.125–0.25%) was lower than the control cheeses without POM. The oscillation rheology test indicated that the transition temperature (tan (δ) = 1) shifted as the POM content increased. The storage modulus (G′) was higher than the loss modulus (G″) during the experiment. The initial storage and loss moduli values were higher after the storage period, correlated with the higher hardness. Non-stored and stored samples had good meltability (Schreiber test number >4). The addition of POM increased antioxidant activity (FRAP). Considering good physicochemical and antioxidative properties, the optimal percentage of POM in processed cheese was 0.25%.
Phenotypic characterisation of Acinetobacter strains of 13 DNA-DNA hybridisation groups by means of the Biolog system (1995)

A collection of 129 Acinetobacter strains belonging to DNA groups (genomic species) 1-14 (1-7 and 10-12 sensu Bouvet and Grimont; 8 and 13-14 sensu Tjernberg and Ursing) were investigated for their ability to oxidise 95 carbon sources in the Biolog system. The strain groupings obtained by cluster analysis with the Biolog software were compared with the results of DNA-DNA hybridisation studies. Strains of DNA groups 1 (A. calcoaceticus), 2 (A. baumannii), 3 and 13 were linked in one cluster, as were DNA groups 4 (A. haemolyticus) and 6, DNA groups 10 and 11, and DNA groups 8 (A. lwoffii) and 12 (A. radioresistens). Strains of DNA group 5 (A. junii) were grouped in a single cluster with one strain of DNA group 4. Strains of DNA groups 7 (A. johnsonii) and 14 formed separate clusters. With the exception of the linkage of DNA groups 8 and 12, these results correlated with classification of reference strains of the DNA groups by DNA-DNA hybridisation, but six strains of four different DNA groups were not allocated to the clusters of their respective DNA groups. In the case of DNA groups 4, 5, 6, 7, 10, 11 and 14, at least one carbon source oxidation test could be used to differentiate them from the other DNA groups.
Analysis and Design of Open-Loop Multiphase Local-Oscillator Generator for Wireless Applications (2010)

Multiphase local-oscillator (LO) generators have been widely adopted in modern wireless communication systems. This paper describes the analysis and design of two open-loop multiphase (quadri and octave) LO generators, which can lead to speed relaxation of the phase-locked loop and voltage-controlled oscillator when compared with conventional frequency-division methods. The mathematical model, sizing considerations, and two design examples targeting mobile-TV applications are presented. The first one is an octave-phase LO generator designed in 90-nm CMOS featuring multiple switchable phase correctors in cascade. It covers the VHF-III and UHF bands with an optimized phase precision within 0.8° . The second one combines quadri- and octave-phase LO generation to cover the full band of mobile TV from 170 to 1700 MHz. Optimized in 65-nm CMOS, it can be operated in octave-phase mode for image-reject harmonic-reject downconversion or in quadri-phase mode for simple image-reject downconversion. Extensive simulations accounting for process variations show that the achieved phase precisions are within 1.5° (quadri) and 1° (octave). The phase-noise performance is comparable with state-of-the-art solutions.
[Transforming growth factor-beta1-loaded fibrin sealant promote bone marrow Mesenchymal stem cells to contract injectable tissue engineering cartilage in vivo]. (2005)

TGF-beta1-loaded FS can promote BMSCs to contract injectable tissue engineering cartilage in vivo.
Enforced expression of human ANGPTL2 induced accumulation of CD8 Positive T cells in db/db mice. (2015)

&lt;p&gt;A, Stromal vascular fraction (SVF) were isolated from the epididymal fat pad then stained with CD3, CD4, and CD8 antibodies and analyzed by FACS. B, CD3+ population. C, CD3+CD8+ population. D, CD3+CD4+ population. E, CD4/CD8 ratio (B-E: n = 4). Data are mean ± SEM, *: P&lt;0.05 compared with LacZ group.&lt;/p&gt;
In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate. (1997)

The present study demonstrates the utility of an in vitro-in vivo correlative approach in the selection of an optimum prodrug candidate of L-767,679 (N-([7-(piperazin-1-yl)-3,4-dihydro-1(1H)-isoquinolinone-2-yl]acetyl)-3(S)-(ethynyl)-beta-alanine), a potent fibrinogen receptor antagonist. As an initial screening step, a comparative in vitro hepatic metabolism study was conducted for L-767,679 and a series of aliphatic and aromatic ester prodrugs in dogs, monkeys, and humans. In all species, the active acid L-767,679, but not the ester prodrugs, was resistant to metabolism. Only the methyl, ethyl, and isopropyl esters were converted exclusively to the active acid in liver microsomal preparations from dogs and humans, and thus were selected for further studies. In the preparations from monkeys, all of the esters investigated were metabolized efficiently to both the active acid and several other products. The absolute formation rates of L-767,679 from the esters followed the rank order: methyl approximately ethyl > isopropyl in all species, and in humans > dogs for the three esters. The three ester prodrugs did not undergo appreciable hydrolysis in blood or upon incubation with intestinal S9 from any of the studied species. In vivo evaluation of the previous three aliphatic esters in dogs and monkeys supported the in vitro findings. L-767,679 was metabolically stable in both dogs and monkeys. After intravenous administration of the prodrugs to either species, the extent of acid formation was higher in dogs than in monkeys. In addition, the extent of L-767,679 formed from these prodrugs followed the rank order: methyl approximately ethyl > isopropyl. Similar results were obtained after oral dosing of the prodrugs, such that the bioavailability of L-767,679 was higher in dogs than in monkeys, and the bioavailability was higher after the ethyl ester than after the isopropyl prodrug in both species. In either species, both ethyl and isopropyl ester prodrugs were better absorbed than L-767,679. Overall, the results suggested that the bioavailability of the active acid after administration of an ester prodrug was dictated primarily by two factors, viz.:1) the relative rates of ester hydrolysis versus competing metabolic reactions and 2) the absolute rates of ester hydrolysis. In the case of L-767,679 prodrugs, absorption was not a limiting factor. Consequently, the bioavailability of L-767,679 after oral administration of the ester prodrugs would likely be greater in humans than in dogs, and in humans would be higher with the ethyl ester than with the isopropyl ester. On this basis, the ethyl ester was considered as a promising candidate for clinical evaluation as a fibrinogen receptor antagonist prodrug.
Splice Variants of the NR1 Subunit Differentially Induce NMDA Receptor-Dependent Gene Expression (2006)

Subunits of the NMDA receptor (NMDAR) associate with many postsynaptic proteins that substantially broaden its signaling capacity. Although much work has been focused on the signaling of NR2 subunits, little is known about the role of the NR1 subunit. We set out to elucidate the role of the C terminus of the NR1 subunit in NMDAR signaling. By introducing a C-terminal deletion mutant of the NR1 subunit into cultured neurons from NR1(-/-) mice, we found that the C terminus was essential for NMDAR inactivation, downstream signaling, and gene expression, but not for global increases in intracellular Ca2+. Therefore, whereas NMDARs can increase Ca2+ throughout the neuron, NMDAR-dependent signaling, both local and long range, requires coupling through the NR1 C terminus. Two major NR1 splice variants differ by the presence or absence of a C-terminal domain, C1, which is determined by alternative splicing of exon 21. Analysis of these two variants showed that removal of this domain significantly reduced the efficacy of NMDAR-induced gene expression without affecting receptor inactivation. Thus, the NR1 C terminus couples to multiple downstream signaling pathways that can be modulated selectively by RNA splicing.
Scan chain design for three-dimensional integrated circuits (3D ICs) (2007)

Scan chains are widely used to improve the testability of IC designs. In traditional 2D IC designs, various design techniques on the construction of scan chains have been proposed to facilitate DFT (Design-For-Test). Recently, three-dimensional (3D) technologies have been proposed as a promising solution to continue technology scaling. In this paper, we study the scan chain construction for 3D ICs, examining the impact of 3D technologies on scan chain ordering. Three different 3D scan chain design approaches (namely, VIA3D, MAP3D, and OPT3D) are proposed and compared, with the experimental results for ISCAS89 benchmark circuits. The advantages as well as disadvantages for each approach are discussed. The results show that both MAP3D and VIA3D approaches require no changes of 2D scan chain algorithms, but OPT3D can achieve the best wire length reduction for the scan chain design. The average scan chain wire length of six ISCAS89 benchmarks obtained from OPT3D has 46.0% reduction compared to the 2D scan chain design. To the best of our knowledge, this is the first study on scan chain design for 3D integrated circuits.