gebhart/patrepeval huggingface dataset:
Transmission Spectrum of Asymmetric Nanostructures for Plasmonic Space Propulsion (2016)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Increase of Metabolic Syndrome Score is an Independent Determinant of Increasing Pulse Pressure (2008)

The present results from this study demonstrate that increasing MetS score is an independent determinant of increasing PP. The results also demonstrate the independent role of MetS in increasing arterial stiffness and PP.
Elevated Expression of Endothelin-1 and Endothelin-Converting Enzyme-1 in Idiopathic Pulmonary Fibrosis: Possible Involvement of Proinflammatory Cytokines (1997)

Endothelin-1 (ET-1) is a vasoconstrictor, bronchoconstrictor, and mitogenic peptide which is enzymatically converted from a biologically inactive big ET to mature ET (21 amino acid) by the ET-converting enzyme (ECE). Here, we investigate the expression of ECE-1, big ET-1, and ET-1 in the lungs of patients with idiopathic pulmonary fibrosis (IPF) and compare it to those of normal subjects using immunohistochemistry and in situ hybridization. In normal lungs, focal moderate expression of all three molecules is localized to airway epithelium, pulmonary endothelium, and airway and vascular smooth muscle cells. Serous bronchial glands also expressed ET-1 and ECE-1. In IPF, strong diffuse expression of ECE-1 was seen in airway epithelium, proliferating type II pneumocytes, and in endothelial and inflammatory cells. ECE-1 immunostaining was colocalized to big ET-1 and ET-1 immunostaining, and correlated with disease activity (P < 0.05). To study regulatory mechanisms of ET-1 and ECE-1 expression, human normal bronchial epithelial (NBE) cells were treated with cytokines and analyzed by radioimmunoassay and Northern blot. Incubation of human NBE cells with IL-1alpha and -beta or tumor necrosis factor alpha (TNFalpha) resulted in a significant increase in ET-1 release and mRNA expression. TNFalpha resulted in a significant increase in ECE-1 mRNA expression. These findings demonstrated the colocalization of the precursor and active ET-1, and ECE-1 in the same cell, and that ECE-1 expression is elevated in IPF. In addition, increased expression of ET-1 and ECE-1 in IPF may be mediated by proinflammatory cytokines.
Vacuumized and Unvacuumized Polyethylene or Polyester Film Bags: Insect Survival and Resistance to Insect Penetration1 (1988)

Journal Article Vacuumized and Unvacuumized Polyethylene or Polyester Film Bags: Insect Survival and Resistance to Insect Penetration Get access Henry A. Highland Henry A. Highland Stored-Product Insects Research and Development Laboratory, USDA-ARS, Savannah, Georgia 31403 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 81, Issue 3, 1 June 1988, Pages 955–958, https://doi.org/10.1093/jee/81.3.955 Published: 01 June 1988 Article history Received: 08 June 1987 Accepted: 05 December 1987 Published: 01 June 1988
On model selection consistency of M-estimators with geometrically decomposable penalties (2013)

Penalized M-estimators are used in diverse areas of science and engineering to fit high-dimensional models with some low-dimensional structure. Often, the penal-ties are geometrically decomposable, i.e. can be expressed as a sum of support functions over convex sets. We generalize the notion of irrepresentable to geomet-rically decomposable penalties and develop a general framework for establishing consistency and model selection consistency of M-estimators with such penalties. We then use this framework to derive results for some special cases of interest in bioinformatics and statistical learning. 1
Generative Adversarial Networks for Morphological–Temporal Classification of Stem Cell Images (2021)

Frequently, neural network training involving biological images suffers from a lack of data, resulting in inefficient network learning. This issue stems from limitations in terms of time, resources, and difficulty in cellular experimentation and data collection. For example, when performing experimental analysis, it may be necessary for the researcher to use most of their data for testing, as opposed to model training. Therefore, the goal of this paper is to perform dataset augmentation using generative adversarial networks (GAN) to increase the classification accuracy of deep convolutional neural networks (CNN) trained on induced pluripotent stem cell microscopy images. The main challenges are: 1. modeling complex data using GAN and 2. training neural networks on augmented datasets that contain generated data. To address these challenges, a temporally constrained, hierarchical classification scheme that exploits domain knowledge is employed for model learning. First, image patches of cell colonies from gray-scale microscopy images are generated using GAN, and then these images are added to the real dataset and used to address class imbalances at multiple stages of training. Overall, a 2% increase in both true positive rate and F1-score is observed using this method as compared to a straightforward, imbalanced classification network, with some greater improvements on a classwise basis. This work demonstrates that synergistic model design involving domain knowledge is key for biological image analysis and improves model learning in high-throughput scenarios.
Experimental evaluation of the response of micro-channel plate detector to ions with 10s of MeV energies (2016)

The absolute calibration of a microchannel plate (MCP) assembly using a Thomson spectrometer for laser-driven ion beams is described. In order to obtain the response of the whole detection system to the particles' impact, a slotted solid state nuclear track detector (CR-39) was installed in front of the MCP to record the ions simultaneously on both detectors. The response of the MCP (counts/particles) was measured for 5-58 MeV carbon ions and for protons in the energy range 2-17.3 MeV. The response of the MCP detector is non-trivial when the stopping range of particles becomes larger than the thickness of the detector. Protons with energies E ≳ 10 MeV are energetic enough that they can pass through the MCP detector. Quantitative analysis of the pits formed in CR-39 and the signal generated in the MCP allowed to determine the MCP response to particles in this energy range. Moreover, a theoretical model allows to predict the response of MCP at even higher proton energies. This suggests that in this regime the MCP response is a slowly decreasing function of energy, consistently with the decrease of the deposited energy. These calibration data will enable particle spectra to be obtained in absolute terms over a broad energy range.
Anti-infective characteristics of a new Carbothane ventricular assist device driveline (2023)

This study provides experimental evidence to support the anti-biofilm activity of the Carbothane driveline and uncovered specific physicochemical features that may explain its ability to inhibit biofilm formation.
Determinants of exercise-induced pulmonary hypertension in patients with normal left ventricular ejection fraction (2008)

Exercise-induced PH is common even in subjects with normal LVEF. It is strongly associated with E/E' ratio, TR velocity, age, systolic blood pressure during exercise and gender.
Quantification of Global DNA Methylation by Capillary Electrophoresis and Mass Spectrometry (2008)

Two approaches for the evaluation of the relative degree of global DNA methylation through the quantification of 2' deoxynucleosides are described. Detection and quantification of 5-methyl 2'-deoxycytidine in genomic DNA is performed using both high-performance capillary electrophoresis (HPCE) with UV-Vis detection or liquid chromatography with electrospray ionization mass spectrometric detection (LC-ESI/MS). Treatment of genomic DNA with a ribonuclease and generation of nucleosides through enzymatic hydrolysis notably increases the specificity of both techniques. Both approaches have been demonstrated to be highly specific and sensitive, being useful for the rapid quantification of the degree of global DNA methylation and its exploitation for the analysis of poorly purified and/or concentrated DNA samples, such as tumor biopsies.
DSP for Mode Division Multiplexing (2013)

We discuss possible architectures and complexity scaling of SDM interfaces that include multiple-input multiple-output digital signal processing (DSP) to deal with coupling between spatial and polarization modes.
Multi-frequency electrical impedance tomography of the breast: new clinical results (2004)

Electrical impedance tomography (EIT) has been used in the recent past for a number of clinical applications. In this work we present recent tomographic and spectroscopic findings for breast imaging from clinical exams completed at Dartmouth. The results presented here are based on 18 normal and 24 abnormal subjects. The participants were classified as normal or abnormal using the American College of Radiology (ACR) indexing system for mammograms. The EIT data were collected for ten discrete frequencies in the range 10 kHz-1 MHz using a single array of 16 electrodes. The finite element method was used to reconstruct the images. The images were examined visually and were compared with mammograms. The results were also analyzed based on zonal averages of property values and breast tissue radiodensities. Statistical analysis showed a significance difference between the mean conductivity and permittivity values of normal and abnormal subjects for various zones defined on the reconstructed images. Tissues with high radiodensity also had increased conductivity and permittivity.
REDUCING THE COGNITIVE LOAD ON ANALYSTS THROUGH HAMMING DISTANCE BASED ALERT AGGREGATION (2014)

Previous work introduced the idea of grouping alerts at a Hamming distance of 1 to achieve lossless alert aggregation; such aggregated meta-alerts were shown to increase alert interpretability. However, a mean of 84023 daily Snort alerts were reduced to a still formidable 14099 meta-alerts. In this work, we address this limitation by investigating several approaches that all contribute towards reducing the burden on the analyst and providing timely analysis. We explore minimizing the number of both alerts and data elements by aggregating at Hamming distances greater than 1. We show how increasing bin sizes can improve aggregation rates. And we provide a new aggregation algorithm that operates up to an order of magnitude faster at Hamming distance 1. Lastly, we demonstrate the broad applicability of this approach through empirical analysis of Windows security alerts, Snort alerts, netflow records, and DNS logs. The result is a reduction in the cognitive load on analysts by minimizing the overall number of alerts and the number of data elements that need to be reviewed in order for an analyst to evaluate the set of original alerts.<br>
Phenotypic Variation and Genetic Architecture for Photosynthesis and Water Use Efficiency in Soybean (Glycine max L. Merr) (2019)

Photosynthesis (<i>A</i>) and intrinsic water use efficiency (<i>WUE</i>) are physiological traits directly influencing biomass production, conversion efficiency, and grain yield. Though the influence of physiological process on yield is widely known, studies assessing improvement strategies are rare due to laborious phenotyping and specialized equipment needs. This is one of the first studies to assess the genetic architecture underlying <i>A</i> and intrinsic <i>WUE</i>, as well as to evaluate the feasibility of implementing genomic prediction. A panel of 383 soybean recombinant inbred lines were evaluated in a multi-environment yield trial that included measurements of <i>A</i> and intrinsic <i>WUE</i>, using an infrared gas analyzer during R4-R5 growth stages. Genetic variability was found to support the possibility of genetic improvement through breeding. High genetic correlation between grain yield (<i>GY</i>) and <i>A</i> (0.80) was observed, suggesting increases in <i>GY</i> can be achieved through the improvement of <i>A</i>. Genome-wide association analysis revealed quantitative trait loci (QTLs) for these physiological traits. Cross-validation studies indicated high predictive ability (>0.65) for the implementation of genomic prediction as a viable strategy to improve physiological efficiency while reducing field phenotyping. This work provides core knowledge to develop new soybean cultivars with enhanced photosynthesis and water use efficiency through conventional breeding and genomic techniques.
Dual-Inverter Topology for Single-Phase Supplied Drive Systems without Electrolytic Capacitor (2021)

Single-phase supplied variable speed drive (VSD) systems are widely used in industrial applications and typically feature a two-stage design with a power factor corrected (PFC) boost rectifier and a three-phase voltage source inverter (VSI). However, the electrolytic DC-link capacitor, which is needed to cope with the twice grid frequency power pulsation, and the required boost inductor are unfavourable in terms of reliability, volume, cost, and complexity. Therefore, the proposed concept employs a dual-inverter topology with a three-phase open-end winding (OEW) machine, avoiding high-frequency inductors, and controls the system such that the power pulsation is buffered in the inertia of the drive train. Accordingly, the DC-link capacitance can be reduced drastically, enabling an electrolytic capacitor-less system, featuring a higher power density and an increased lifetime. This paper presents the operating principle and the corresponding closed-loop control structure, to achieve PFC operation, DC-link voltage balancing and average speed control. Detailed analysis reveals that the machine voltage can be selected independently of the grid peak voltage in contrast to existing concepts. The converter performance is evaluated based on simple performance indices with respect to the machine voltage. In the context of a 7.5kW compressor application for railway brakes with a wide input voltage range, a semiconductor loss reduction of 30% can be obtained compared to a state-of-the-art approach, further reducing the converter volume. Finally, the proper operation is verified with a closed-loop circuit simulation.
“Out of My League”: A Real-World Test of the Matching Hypothesis (2011)

The matching hypothesis predicts that individuals on the dating market will assess their own self-worth and select partners whose social desirability approximately equals their own. It is often treated as well established, despite a dearth of empirical evidence to support it. In the current research, the authors sought to address conceptual and methodological inconsistencies in the extant literature and to examine whether matching occurs as defined by Walster et al. and more generally. Using data collected in the laboratory and from users of a popular online dating site, the authors found evidence for matching based on self-worth, physical attractiveness, and popularity, but to different degrees and not always at the same stage of the dating process.
Exploring the Effects of Teacher Job Satisfaction on Teaching Effectiveness: Using 'Teaching Quality Assurance' as the Mediator (2013)

Previous studies have shown that ultrasound (US) could enhance cellular uptake and cytotoxicity of chemotherapeutic agents in drug-resistant cancer cells. The goal of this study was to investigate the optimization of physical parameters of US exposure for in vitro reversal of multidrug resistance (MDR) in human hepatocarcinoma cell line (HepG2). Using a constant total energy density (3.87 J/cm(2)) that could maintain cell viability at the 90% level, we exposed parent (HepG2) and MDR variant (HepG2/ADM) tumor cells to US in vitro to a variety of US frequency, exposure intensity and duty cycle. After US exposure, flow cytometry was performed to measure retention of rhodamine 123 (Rh123) in both HepG2 and HepG2/MDR cells. The results showed that US frequency and duty cycle (DC) could influence the intracellular retention of Rh123 in HepG2/ADM tumor cells; intensity and exposure duration appeared to be of little importance. At a constant total energy density of 3.87 J/cm(2), the optimal US parameters for in vitro reversal of MDR in HepG2/ADM tumor cells appear to be 0.8 MHz, 0.43 W/cm(2) and 60% DC, respectively. These findings support our hypothesis that varying the physical parameters would have an effect on efficiency of US-mediated reversal of MDR in cancer cells.
EPSTEIN-BARR VIRUS IN SQUAMOUS CELL CARCINOMA AFTER RENAL TRANSPLANTATION (1995)

Departments of Oral Surgery, Medicine, and Pathology, Cardiff Dental Hospital, Heath Park, CF4 3PU; and Departments of Haematology and Pathology, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, United Kingdom
Peak Systolic Velocity Doppler Index Reflects Most Appropriately the Dynamic Time Course of Intact Cerebral Autoregulation (2002)

Our data show peak systolic blood flow velocity index to be most accurate for measuring effectiveness of the dynamic CA mechanism. No differences in the CA were found between the vascular territory of the middle and posterior cerebral arteries.
Proteins from Multiple Metabolic Pathways Associate with Starch Biosynthetic Enzymes in High Molecular Weight Complexes: A Model for Regulation of Carbon Allocation in Maize Amyloplasts (2009)

Starch biosynthetic enzymes from maize (Zea mays) and wheat (Triticum aestivum) amyloplasts exist in cell extracts in high molecular weight complexes; however, the nature of those assemblies remains to be defined. This study tested the interdependence of the maize enzymes starch synthase IIa (SSIIa), SSIII, starch branching enzyme IIb (SBEIIb), and SBEIIa for assembly into multisubunit complexes. Mutations that eliminated any one of those proteins also prevented the others from assembling into a high molecular mass form of approximately 670 kD, so that SSIII, SSIIa, SBEIIa, and SBEIIb most likely all exist together in the same complex. SSIIa, SBEIIb, and SBEIIa, but not SSIII, were also interdependent for assembly into a complex of approximately 300 kD. SSIII, SSIIa, SBEIIa, and SBEIIb copurified through successive chromatography steps, and SBEIIa, SBEIIb, and SSIIa coimmunoprecipitated with SSIII in a phosphorylation-dependent manner. SBEIIa and SBEIIb also were retained on an affinity column bearing a specific conserved fragment of SSIII located outside of the SS catalytic domain. Additional proteins that copurified with SSIII in multiple biochemical methods included the two known isoforms of pyruvate orthophosphate dikinase (PPDK), large and small subunits of ADP-glucose pyrophosphorylase, and the sucrose synthase isoform SUS-SH1. PPDK and SUS-SH1 required SSIII, SSIIa, SBEIIa, and SBEIIb for assembly into the 670-kD complex. These complexes may function in global regulation of carbon partitioning between metabolic pathways in developing seeds.
Regular exercise prevents the development of hyperglucocorticoidemia via adaptations in the brain and adrenal glands in male Zucker diabetic fatty rats (2010)

We determined the effects of voluntary wheel running on the hypothalamic-pituitary-adrenal (HPA) axis, and the peripheral determinants of glucocorticoids action, in male Zucker diabetic fatty (ZDF) rats. Six-week-old euglycemic ZDF rats were divided into Basal, Sedentary, and Exercise groups (n = 8-9 per group). Basal animals were immediately killed, whereas Sedentary and Exercising rats were monitored for 10 wk. Basal (i.e., approximately 0900 AM in the resting state) glucocorticoid levels increased 2.3-fold by week 3 in Sedentary rats where they remained elevated for the duration of the study. After an initial elevation in basal glucocorticoid levels at week 1, Exercise rats maintained low glucocorticoid levels from week 3 through week 10. Hyperglycemia was evident in Sedentary animals by week 7, whereas Exercising animals maintained euglycemia throughout. At the time of death, the Sedentary group had approximately 40% lower glucocorticoid receptor (GR) content in the hippocampus, compared with the Basal and Exercise groups (P < 0.05), suggesting that the former group had impaired negative feedback regulation of the HPA axis. Both Sedentary and Exercise groups had elevated ACTH compared with Basal rats, indicating that central drive of the axis was similar between groups. However, Sedentary, but not Exercise, animals had elevated adrenal ACTH receptor and steroidogenic acute regulatory protein content compared with the Basal animals, suggesting that regular exercise protects against elevations in glucocorticoids by a downregulation of adrenal sensitivity to ACTH. GR and 11beta-hydroxysteroid dehydrogenase type 1 content in skeletal muscle and liver were similar between groups, however, GR content in adipose tissue was elevated in the Sedentary groups compared with the Basal and Exercise (P < 0.05) groups. Thus, the gradual elevations in glucocorticoid levels associated with the development of insulin resistance in male ZDF rats can be prevented with regular exercise, likely because of adaptations that occur primarily in the adrenal glands.
Regulation of Trib2 gene expression in normal and AML cells (2011)

The mammalian Trib family consists of Trib1, Trib2 and Trib3.Elevated levels of Trib2 have been linked with murine AML andassociates with a specific subset of human AML with Notch1mutations and dysregulated C/EBPa. However the regulation of Tribexpression is poorly understood; understanding this regulation isimportant both physiologically and pathologically.Promoter analyses indicated that several possible E2F1 bindingsites exist within the Trib2 promoter region. A complex regulatoryrelationship exists between C/EBPa and E2F1, and proliferationarrest mediated by C/EBPa involves repression of E2F1-target genes.Luciferase assays using a Trib2 promoter construct demonstratedthat E2F1 is a positive regulator of Trib2 and that this positiveinduction was dependent on E2F1’s ability to bind directly to DNA.Further analyses revealed that this activation is repressed by wild type C/EBPa. Importantly, C/EBPap30, an N-terminal truncateddominant negative C/EBPa isoform commonly associated with AMLco-operated with E2F1 to induce Trib2 promoter activity. Bioinfor-matic analysis of human AML datasets revealed a negativecorrelation between Trib2 and C/EBPa expression, and a positivecorrelation between Trib2 and Notch1 expression. These resultscorrespond with our previous findings that Trib2 is a Notch1 targetgene and functions to degrade and inhibit wild type C/EBPa. Furtheranalyses demonstrated a positive correlation between Trib2 and E2F1expression in the human AML dataset supporting our findings.Together these data indicate a positive regulatory pathway forTrib2 expression mediated by E2F1 and C/EBPap30, and a negativeregulatory pathway involving E2F1 and wild type C/EBPa.