gebhart/patrepeval huggingface dataset:
Surface Modification of Melt Extruded Poly(ε-caprolactone) Nanofibers: Toward a New Scalable Biomaterial Scaffold (2014)

A photochemical modification of melt-extruded polymeric nanofibers is described. A bioorthogonal functional group is used to decorate fibers made exclusively from commodity polymers, covalently attach fluorophores and peptides, and direct cell growth. Our process begins by using a layered coextrusion method, where poly(ε-caprolactone) (PCL) nanofibers are incorporated within a macroscopic poly(ethylene oxide) (PEO) tape through a series of die multipliers within the extrusion line. The PEO layer is then removed with a water wash to yield rectangular PCL nanofibers with controlled cross-sectional dimensions. The fibers can be subsequently modified using photochemistry to yield a "clickable" handle for performing the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction on their surface. We have attached fluorophores, which exhibit dense surface coverage when using ligand-accelerated CuAAC reaction conditions. In addition, an RGD peptide motif was coupled to the surface of the fibers. Subsequent cell-based studies have shown that the RGD peptide is biologically accessible at the surface, leading to increased cellular adhesion and spreading versus PCL control surfaces. This functionalized coextruded fiber has the advantages of modularity and scalability, opening a potentially new avenue for biomaterials fabrication.
Numerische Abbildung von Spaltprofilierprozessen und Bruchmechanische Beschreibung des Rissfortschrittsverhaltens von spaltprofilierten Strukturen (2014)

Im Rahmen der Forschungstätigkeiten des Sonderforschungsbereichs666 werden die Spaltprofilierverfahren weiterentwickelt. Innerhalb des ersten Teil dieses Teilprojektes steht die Abbildung der Verfahren mittels numerischer Methoden im Fokus. Die Finite Elemente Methode bietet hierfür ein sehr großes Potenzial und ist in der Industrie etabliert. Mit Hilfe der FEM lassen sich die Entwicklungszeiten reduzieren und so Kosten senken. Im ersten Teil dieses Beitrages wird eine neue Methode zur Verifikation von FE-Simulationen des Spaltprofilierprozessen vorgestellt. Im Anschluss wird eine Erweiterung der zuvor entwickelten Cut-Expand-Methode auf die Cut-FlexibleExpand-Methode beschrieben. Mit dieser lässt sich auch das flexible Spaltprofilieren effizient simulieren Im zweiten Teil des Beitrags geht es um die bruchmechanische Beschreibung des Rissfortschrittsverhaltens von spaltprofilierten Strukturen. Die Berücksichtigung der Restlebensdauer nach der Rissinitiierung bei der Schwingfestigkeitsanalyse kann die Abschätzung der Lebensdauer unter schwingender Belastung verbessern. Es wird ein bruchmechanischer Ansatz beschrieben, der das gefügeabhängige Rissfortschrittsverhalten und die fertigungsinduzierten Eigenspannungsfelder in der Rissfortschrittsanalyse berücksichtigt. In diesem Zusammenhang wird eine Methode zur experimentellen Bestimmung zyklischer bruchmechanischer Kennwerte in spaltprofilierten Strukturen entwickelt. Eine analytische Näherungslösung wird beschrieben, um den Spannungsintensitätsfaktor in der spaltprofilierten Struktur zu ermitteln. Die Ergebnisse werden mit den Ergebnissen aus FE-Berechnungen verglichen.
Solution-Phase Synthesis of Well-Defined Indium Sulfide Nanorods (2009)

Cubic β-In2S3 nanorods were synthesized with reaction conditions that favor anisotropic growth. The TEM image illustrates the uniform diameter of the nanorods (11.5 nm), which is well below the Bohr radius of In2S3. Optoelectronic and electrochemical characterization suggests these nanorods may represent a viable alternative to CdS and CdSe nanostructures.
[DNA analysis and prenatal diagnosis in cystic fibrosis]. (1991)

Cystic fibrosis (CF) is the most common autosomal recessive lethal genetic disorder in man, affecting 1 in 2,000 live births. The carrier frequency in Caucasians is 1 in 20. Approximately 70 per cent of the mutations correspond to a specific deletion on chromosome 7 (region 7q31). This delta F 508 mutation of the CF gene results in the loss of phenylalanine at position 508 in the gene product. About 50 per cent of the individuals with CF are homozygous for this deletion and suffer from pancreatic insufficiency. The remaining half are mostly compound heterozygotes between this deletion and another mutation. They exhibit less severe symptoms. Several simple polymerase chain reaction (PCR) tests are available to detect the delta F 508 mutation, allowing rapid prenatal diagnosis of the disease. In those families where other mutations of the CF gene are involved prenatal diagnosis is performed by means of tightly linked restriction fragment length polymorphisms (RFLPs). PCR tests are available for RFLP analysis too. Testing for the delta F 508 deletion, present in about 3 per cent of the normal population, may prove invaluable for extensive carrier screening. Thus, half of the couples at risk could be recognized before the first affected child is born.
Salivary Concentrations of Urea Released from a Chewing Gum Containing Urea and how These Affect the Urea Content of Gel–Stabilized Plaques and Their pH after Exposure to Sucrose (2001)

The objectives were to: (1) determine the salivary concentrations of urea during 20 min chewing of a sugar-free gum containing 30 mg of urea; (2) measure the degree to which this urea would diffuse into a gel-stabilized plaque; (3) study the effect of the urea on the fall and subsequent rise in pH (Stephan curve) on exposure to 10% sucrose for 1 min; (4) model the measurements 2 and 3 mathematically. In point 1, the salivary urea concentration of the 12 subjects peaked at 47 mmol/l in the first 2 min of gum chewing, falling within 15 min to the unstimulated salivary concentration of 3.4 mmol/l. Recovery of urea from the saliva averaged 81.5%. 'Plaques' of 1% agarose or 67% dead bacteria in agarose accumulated urea from the saliva roughly as expected, whereas those plaques containing 8% live and 59% dead Streptococcus vestibularis showed negligible accumulation. Computer modelling showed this difference to be due to urease of live bacteria breaking down the urea as rapidly as it entered the plaque. Simulation of the effect of gum chewing subsequent to initiation of a Stephan curve in the latter type of plaque showed a rapid rise in pH but then a fall again on return to unstimulated conditions. This fall had not been seen in previous studies, with Streptococcus oralis, nor was it predicted by the computer modelling. Neither experimental simulation nor computer modelling suggested that chewing urea-containing gum before exposure to sucrose would have any effect on a subsequent Stephan curve. Thus chewing gum is only likely to inhibit caries when it is chewed after consumption of fermentable carbohydrate, rather than before.
Transcriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes (2021)

High-charge, high-energy ion particle (HZE) radiations are extraterrestrial in origin and characterized by high linear energy transfer (high-LET), which causes more severe cell damage than low-LET radiations like γ-rays or photons. High-LET radiation poses potential cancer risks for astronauts on deep space missions, but the studies of its carcinogenic effects have relied heavily on animal models. It remains uncertain whether such data are applicable to human disease. Here, we used genomics approaches to directly compare high-LET radiation-induced, low-LET radiation-induced and spontaneous hepatocellular carcinoma (HCC) in mice with a human HCC cohort from The Cancer Genome Atlas (TCGA). We identified common molecular pathways between mouse and human HCC and discovered a subset of orthologous genes (mR-HCC) that associated high-LET radiation-induced mouse HCC with a subgroup (mrHCC2) of the TCGA cohort. The mrHCC2 TCGA cohort was more enriched with tumor-suppressing immune cells and showed a better prognostic outcome than other patient subgroups.
RELATIONSHIP OF THE P LOOP MEASUREMENTS TO PULMONARY ARTERY WEDGE PRESSURE AND LEFT ATRIAL VOLUME IN PURE MITRAL STENOSIS (1976)

Frank vectorcardiographic P loops with satisfactory signal to noise ratio were obtained from 28 patients with pure mitral stenosis by using computer-averaging technique of eight successive beats. Twenty-three parameters of the P loop automatically measured were compared with the mean pulmonary artery wedge pressure (mPAW) and the maximal left atrial volume (max. LAV) calculated from biplane angiocardiogram by the area-length method. There was a significant correlation between the m PAW and four P loop measurements. The positive amplitude in lead Z (the posterior component) showed the highest correlation with the mPAW (r=0.54, p less than 0.01). In the multiple regression analysis, the predicted m PAW using eight P loop measurements and the measured m PAW showed a high significant correlation (r=0.86, p less than 0.01). There were significant correlations between the max. LAV and fourteen P loop measurements. The magnitude of spatial maximal P-vector showed the highest correlation with the max. LAV (r=0.86, P less than 0.01). In the multiple regression analysis, the predicted max. LAV using four P loop measurements out of 23 showed the best correlation with the measured max. LAV (r=0.94, P less than 0.01).
Extended tunnelling states in the benzoic acid crystal: Infrared and Raman spectra of the OH and OD stretching modes (2006)

We compare Raman and infrared spectra of the nuOH/OD modes in benzoic acid crystal powders at 7 K. The extremely sharp Raman bands contrast to the broad infrared profiles and suggest adiabatic separation of hydrogen (deuterium) dynamics from the crystal lattice. There is no evidence of any proton-proton coupling term. The assignment scheme is consistent with a quasisymmetric double-minimum potential, largely temperature independent. Tunnel splitting is a major band shaping mechanism, in addition to anharmonic coupling with lattice modes. The proton/deuteron dynamics are rationalized with nonlocal pseudoparticles and extended states. We propose a symmetry-related damping mechanism to account for the broad infrared profiles, as opposed to the sharp Raman bands. We assign spectral features to distinct interconversion mechanisms based on either pseudoparticle transfer or adiabatic pairwise transfer. We establish close contacts with theoretical models based on first-principles calculations.
Direct targets of theD. melanogasterDSXF protein and the evolution of sexual development (2011)

Uncovering the direct regulatory targets of doublesex (dsx) and fruitless (fru) is crucial for an understanding of how they regulate sexual development, morphogenesis, differentiation and adult functions (including behavior) in Drosophila melanogaster. Using a modified DamID approach, we identified 650 DSX-binding regions in the genome from which we then extracted an optimal palindromic 13 bp DSX-binding sequence. This sequence is functional in vivo, and the base identity at each position is important for DSX binding in vitro. In addition, this sequence is enriched in the genomes of D. melanogaster (58 copies versus approximately the three expected from random) and in the 11 other sequenced Drosophila species, as well as in some other Dipterans. Twenty-three genes are associated with both an in vivo peak in DSX binding and an optimal DSX-binding sequence, and thus are almost certainly direct DSX targets. The association of these 23 genes with optimum DSX binding sites was used to examine the evolutionary changes occurring in DSX and its targets in insects.
Russia, Britain, and the House of Nassau: The Re-Establishment of the Orange Dynasty in the Netherlands, March-November 1813 (2018)

Tsar Alexander i, in pursuit of the retreating Grande Arme, passed through the Prussian city of Breslau.The Prince of Orange, William vi, who was residing in exile on his private estates nearby, seized the opportunity to meet the Tsar to request his assistance in retaking the Netherlands for the House of Orange.The Tsar was quick to pledge his support, and he accepted Orange into the anti-Napoleonic coalition that would defeat Napoleon in 1814. 2 This anecdote raises several questions about the return of the House of Orange to the Netherlands.How could a stateless, destitute, and exiled dynasty convince the Tsar to support its plans for a return to the Netherlands?Why did the other great powers follow suit?And why was the Prince of Orange in London at the outbreak of the uprising in the Netherlands in 1813, rather than with the allied armies in Central Europe?The aim of this article is to explore how the House of Orange navigated the tumultuous
Guillain‐Barré Syndrome and Fisher's Syndrome Following Campylobacter jejuni Infectiona (1998)

The patients with Guillain-Barré Syndrome (GBS) subsequent to Campylobacter jejuni enteritis showed axonal degeneration and had IgG anti-GM1 antibody. The most frequently isolated C. jejuni from the patients was specific serotype of Penner's 19 in Japan. In the lipopolysaccharide (LPS) in C. jejuni of this serotype, the same oligosaccharide structure as GM1 ganglioside existed, suggesting the molecular mimicry between GM1 in nervous tissue and C. jejuni LPS. IgG anti-GM1 antibody may bind the nodes of Ranvier and axon terminals and causes degeneration of the motor axon. Some patients develop Fisher's syndrome following C. jejuni infection. C. jejuni strains from the patients who had IgG anti-GQ1b antibody in the acute phase had GQ1b epitope in their LPS, and the molecular mimicry between GQ1b in nervous tissue and an antecedent infectious agent was clarified.
Comparison of Extracorporeal Shock Wave Lithotripsy and Percutaneous Nephrolithotomy for the Treatment of Renal Calculi in Lower Pole Calices (1989)

Lower pole caliceal calculi can be treated by percutaneous nephrolithotomy (PCNL) or by extracorporeal shock wave lithotripsy (ESWL). In previous studies, investigators have noted that stones in lower calices treated with ESWL have a poor clearance rate. This study compared PCNL and ESWL treatments for solitary lower caliceal stones. Thirty-five patients with lower pole caliceal stones were treated with ESWL (Dornier HM3), and 29 patients were treated with PCNL between March 1983 and January 1988. Pretreatment intravenous urograms of the ESWL patients were examined, and the length and width of the lower pole infundibulum were recorded. The mean stone diameter was 9 mm (range 3 to 30 mm) in the ESWL group and 10 mm (range 4 to 27 mm) in the PCNL group. All patients in the ESWL group had adequate stone fragmentation (particles <4 mm). Stone composition was similar for the two groups. A plain film was obtained at a median follow-up of 13 months in 94% of the ESWL patients and 90% of the PCNL patients. There was a 59% stone-free rate for the ESWL group and an 85% stone-free rate for the PCNL group. The ESWL stone-free rate did not correlate with infundibular width or length. The ESWL patients spent 2.5 days in the hospital ν 6.1 days for the PCNL patients. The PCNL patients had a two-fold greater recovery time (19.3 days ν 10 days). Interestingly, there was no difference between the two treatment groups in regard to recurrent stone disease: 10% of ESWL patients had a recurrence within 18 months, and 11% of the PCNL patients had a recurrence within 22 months after treatment. PCNL for caliceal stones is more invasive, has a higher morbidity, and is
Flexible construction of irregular partitioned permutation LDPC codes with low error floors (2005)

Irregular partitioned permutation (IPP) low-density parity-check (LDPC) codes have been recently introduced to facilitate hardware implementation of belief propagation (BP) decoders. In this letter, we present a new method to construct IPP LDPC codes with great flexibility in the selection of code parameters. Meanwhile, small stopping sets are avoided in the code construction, thus good error floor performance can be achieved.
Perceptual Learning Is Specific to the Trained Structure of Information (2013)

What do we learn when we practice a simple perceptual task? Many studies have suggested that we learn to refine or better select the sensory representations of the task-relevant dimension. Here we show that learning is specific to the trained structural regularities. Specifically, when this structure is modified after training with a fixed temporal structure, performance regresses to pretraining levels, even when the trained stimuli and task are retained. This specificity raises key questions as to the importance of low-level sensory modifications in the learning process. We trained two groups of participants on a two-tone frequency discrimination task for several days. In one group, a fixed reference tone was consistently presented in the first interval (the second tone was higher or lower), and in the other group the same reference tone was consistently presented in the second interval. When following training, these temporal protocols were switched between groups, performance of both groups regressed to pretraining levels, and further training was needed to attain postlearning performance. ERP measures, taken before and after training, indicated that participants implicitly learned the temporal regularity of the protocol and formed an attentional template that matched the trained structure of information. These results are consistent with Reverse Hierarchy Theory, which posits that even the learning of simple perceptual tasks progresses in a top-down manner, hence can benefit from temporal regularities at the trial level, albeit at the potential cost that learning may be specific to these regularities.
New Architectures for Low-Cost Public Key Cryptography on RFID Tags (2007)

Although it is commonly believed that the computational complexity of public key cryptography prevents its deployment on low-cost RFID tags, it was recently demonstrated (McLoone and Robshaw, 2007) that the GPS identification scheme provides a counter-example to this view; with regards to all three attributes of space, power, and timing, GPS is well-suited to low-cost implementation. In this paper we consider new and innovative hardware architectures for implementing the GPS identification scheme and these allow a broader range of practical performance trade-offs.
What to Value and How to Value That is the Question ... (2014)

To value or not to value – that is the question --Title on pdf
On-Board Strontium Getters for Improved Solid Oxide Cell Durability (2022)

Nano-composite electrodes fabricated by introducing nano-sized mixed ionic and electronic conducting (MIEC) catalysts into partially-sintered micro-sized ionic conducting backbones have been used by many researchers to improve the electrochemical performance, and/or reduce the operating temperature, of Solid Oxide Cells (SOCs). 1 Unfortunately, these infiltrated electrodes have often possessed poor electrochemical performance stability. 2 This presentation will review recent results showing how pre-infiltrated ceria nano-particles 3 or atomic layer deposited zirconia overcoats 4 can be used as on-board Sr getters to increase the long-term stability of La 0.6 Sr 0.4 Co 0.8 Fe 0.2 O 3-x (LSCF)-infiltrated Ce 0.9 Gd 0.1 O 1.95-x (GDC) SOC electrodes, without compromising initial performance. This talk will also present results showing that when combined, these surface modification techniques result in LSCF-GDC performance degradation rates that are no better than those obtained from each technique used separately. Lastly, this talk will present GDC pre-infiltration results supporting a newly-emerging consensus that Sr does not surface segregate in Sm 0.5 Sr 0.5 CoO 3-x (SSC) like it does in LSCF. References D. Ding, X. X. Li, S. Y. Lai, K. Gerdes and M. L. Liu, Energy Environ. Sci. , 7 , 552 (2014). M. Shah, P. W. Voorhees and S. A. Barnett, Solid State Ionics , 187 , 64 (2011). Y. Zhang and J. D. Nicholas, Journal of the Electrochemical Society , 168 , 024522 (2021). Y. Zhang, Y. Wen, K. Huang and J. D. Nicholas, ACS Applied Energy Materials , 3 , 4057 (2020).
Proteinase-Activated Receptor-2 Mediates Arterial Vasodilation in Diabetes (2005)

Our data demonstrate an important role for PAR2 in modulating vascular arterial response in diabetes and suggest that this receptor could represent an useful therapeutic target.
Combined Scanning Force Microscopy and Electrochemical Quartz Microbalance in-Situ Investigation of Specific Adsorption and Phase Change Processes at the Silver/Halogenide Interface (1997)

Specific adsorption of halogenides and silver halogenide phase formation was investigated by the combination of electrochemical quartz microbalance measurements (EQMB), topographical in-situ scanning force microscopy (SFM), and in-situ lateral force microscopy (LFM). In-situ LFM can be employed to monitor specific adsorption and, more generally, chemical conversion reactions in submonolayers of atomic species which are inaccessible to topological imaging by SFM. Reorganization of the electrochemical double layer during specific adsorption caused nanotribological changes. Hydrated anions in the outer Helmholtz plain are not locally bonded to a specific site and give low LFM friction values. Specifically adsorbed anions and ion pairs, on the other hand, impede the lateral cantilever translation, resulting in increased friction. EQMB measurements yielded data corresponding to the formation of up to one monolayer of specifically adsorbed cation−halogenide ion pairs. Anodic dissolution of silver to AgO- and the formation of Ag2O islands in a halogenide-free alkaline solution contributed to a roughening of the surface. Long range in-situ SFM showed that silver halogenide phases are anodically nonuniformly formed as smooth islands located in no observable correspondence to grain surfaces or boundaries suggesting a dissolution−precipitation growth mechanism. AgI and AgBr phases can almost reversibly be reduced. Irreversible mass gains after an oxidation−reduction cycle can be associated with Ag deposition near surface steps from soluble Ag and AgB species which were dissolved into the electrolyte bulk during previous anodic scans in the dissolution potential range. In the presence of chloride, the silver surface is vigorously electropolished and soluble AgC species evolve, while AgCl islands precipitate on the newly generated surface regardless of the original silver grain topography.
Reversible Dissociation of Crystalline Yeast Phosphoglyceric Acid Mutase in Alkali (1970)

The structure of crystalline yeast phosphoglyceric acid mutase has been investigated by sedimentation-velocity and equilibrium measurements, optical rotatory dispersion measurements and viscometry. The data indicate that this enzyme is a globular, compact and highly organized protein with a low helix content. The native structure remains unchanged at pH 10.5. Dissociation of the enzyme into subunits has been observed at pH values of 11.5 and above. From optical rotatory dispersion measurements, it is found that the enzyme loses a large part of its organized conformation when it dissociates in alkaline solution. On neutralization, the alkali-treated enzyme regains its activity. The ability to regain the enzyme activity is gradually lowered with the increase of pH value to be incubated and with time of exposure. Inactivation at pH 13.0 is almost irreversible. However, the reversibility of the inactivation at pH 13.0 is appreciably enhanced by the presence of phosphate compounds in the reactivation system. Particulary, it is found that presence of substrates or the coenzyme is effective for considerable improvement of the reversibility. Molecular weight analyses by ultracentrifugation indicate that subunits have approximately equal molecular weights and that the native enzyme is consisted of four polypeptide chains.
Neuroinflammatory markers associate with cognitive decline after major surgery: Findings of an explorative study (2020)

Surgery rapidly triggers a temporal neuroinflammatory response closely associated with long-term cognitive outcome postsurgery. The findings of this explorative study require validation in a larger surgical patient cohort. Ann Neurol 2020;87:370-382.