gebhart/patrepeval huggingface dataset:
Coordination Metallacycles of an Achiral Dendron Self-Assemble via Metal−Metal Interaction To Form Luminescent Superhelical Fibers (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTCoordination Metallacycles of an Achiral Dendron Self-Assemble via Metal−Metal Interaction To Form Luminescent Superhelical FibersMasashi Enomoto, Akihiro Kishimura, and Takuzo AidaView Author Information Department of Chemistry and Biotechnology Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan Cite this: J. Am. Chem. Soc. 2001, 123, 23, 5608–5609Publication Date (Web):May 18, 2001Publication History Received19 February 2001Published online18 May 2001Published inissue 1 June 2001https://pubs.acs.org/doi/10.1021/ja010426thttps://doi.org/10.1021/ja010426trapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views2307Altmetric-Citations198LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Dendrons,Fibers,Luminescence,Metals,Self organization Get e-Alerts
Immunomodulation and Antioxidant Activities as Possible Trypanocidal and Cardioprotective Mechanisms of Major Terpenes from Lippia alba Essential Oils in an Experimental Model of Chronic Chagas Disease (2021)

In the late phase of <i>Trypanosoma cruzi</i> infection, parasite persistence and an exaggerated immune response accompanied by oxidative stress play a crucial role in the genesis of Chronic Chagasic Cardiomyopathy (CCC). Current treatments (Benznidazole (BNZ) and Nifurtimox) can effect only the elimination of the parasite, but are ineffective for late stage treatment and for preventing heart damage and disease progression. In vivo trypanocidal and cardioprotective activity has been reported for <i>Lippia alba</i> essential oils (EOs), ascribed to their two major terpenes, limonene and caryophyllene oxide. To investigate the role of antioxidant and immunomodulatory mechanisms behind these properties, chronic-<i>T. cruzi</i>-infected rats were treated with oral synergistic mixtures of the aforementioned EOs. For this purpose, the EOs were optimized through limonene-enrichment fractioning and by the addition of exogenous caryophyllene oxide (LIMOX) and used alone or in combined therapy with subtherapeutic doses of BNZ (LIMOXBNZ). Clinical, toxicity, inflammatory, oxidative, and parasitological (qPCR) parameters were assessed in cardiac tissue. These therapies demonstrated meaningful antioxidant and immunomodulatory activity on markers involved in CCC pathogenesis (IFN-γ, TNF-α, IL-4, IL-10, and iNOS), which could explain their significant trypanocidal properties and their noteworthy role in preventing, and even reversing, the progression of cardiac damage in chronic Chagas disease.
Omnidirectional video stabilisation on a virtual camera using sensor fusion (2010)

This paper presents a method for robustly stabilising omnidirectional video given the presence of significant rotations and translations by creating a virtual camera and using a combination of sensor fusion and scene tracking. Real time rotational movements of the camera are measured by an Inertial Measurement Unit (IMU), which provides an initial estimate of the ego-motion of the camera platform. Image registration is then used to refine these estimates. The calculated ego-motion is then used to adjust an extract of the omnidirectional video, forming a virtual camera that is focused on the scene. Experiments show the technique is effective under challenging ego-motions and overcomes deficiencies that are associated with unimodal approaches making it robust and suitable to be used in many surveillance applications.
On obstructions in relation to a fixed viewpoint (1989)

108 Efficient, randomized algorithms are given for the following problems: (1) construction of levels of order 1 to k in an arrangement of hyperplanes in any dimension; (2) construction of higher order Voronoi diagrams of order 1 to k in any dimension; (3) hidden surface removal for completely general scenes (intersecting and curved faces are allowed). A combinatorial tool in the form of a mathematical series called a theta series is associated with a configuration of polytopes in R/sup d/. It is used to study the combinatorial, as well as algorithmic, complexity of the geometric problems under consideration.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Development of autonomous navigation system for an indoor service robot application (2013)

This paper describes an autonomous navigation system for an indoor service robot application. A navigation system is one of the most important skills for a service robot application. To make the robot go to its goal pose, a navigation software generally includes a map building, a localization, a path planning and an obstacle avoidance algorithm. The proposed navigation system uses grid map information. The Monte Carlo localization algorithm and A-star path planning algorithm are applied to the navigation system. The proposed navigation system is tested under a simulation environment and shows good performance for a service robot application.
Cell therapy for cancer – our synthetic future (2014)

It is now well established that the immune system can control and eliminate cancer cells. Adoptive T-cell transfer has the potential to overcome the significant limitations associated with vaccine-based strategies in patients who are often immunocompromised. Application of the emerging discipline of synthetic biology to cancer, which combines elements of genetic engineering and molecular biology to create new biological structures with enhanced functionalities, is the subject of this article. Various chimeric antigen receptor designs, manufacturing processes and study populations, among other variables, have been tested and reported in recent clinical trials. Many questions remain unanswered in the field of engineered T-cells, but the encouraging response rates pave a wide road for future investigation.
The virtual microscope (2003)

We present the design and implementation of the Virtual Microscope, a software system employing a client/server architecture to provide a realistic emulation of a high power light microscope. The system provides a form of completely digital telepathology, allowing simultaneous access to archived digital slide images by multiple clients. The main problem the system targets is storing and processing the extremely large quantities of data required to represent a collection of slides. The Virtual Microscope client software runs on the end user's PC or workstation, while database software for storing, retrieving and processing the microscope image data runs on a parallel computer or on a set of workstations at one or more potentially remote sites. We have designed and implemented two versions of the data server software. One implementation is a customization of a database system framework that is optimized for a tightly coupled parallel machine with attached local disks. The second implementation is component-based, and has been designed to accommodate access to and processing of data in a distributed, heterogeneous environment. We also have developed caching client software, implemented in Java, to achieve good response time and portability across different computer platforms. The performance results presented show that the Virtual Microscope systems scales well, so that many clients can be adequately serviced by an appropriately configured data server.
Effects of phase regression on high-resolution functional MRI of the primary visual cortex (2020)

High-resolution functional MRI studies have become a powerful tool to non-invasively probe the sub-millimeter functional organization of the human cortex. Advances in MR hardware, imaging techniques and sophisticated post-processing methods have allowed high resolution fMRI to be used in both the clinical and academic neurosciences. However, consensus within the community regarding the use of gradient echo (GE) or spin echo (SE) based acquisition remains largely divided. On one hand, GE provides a high temporal signal-to-noise ratio (tSNR) technique sensitive to both the macro- and micro-vascular signal while SE based methods are more specific to microvasculature but suffer from lower tSNR and specific absorption rate limitations, especially at high field and with short repetition times. Fortunately, the phase of the GE-EPI signal is sensitive to vessel size and this provides a potential avenue to reduce the macrovascular weighting of the signal (phase regression, Menon 2002). In order to determine the efficacy of this technique at high-resolution, phase regression was applied to GE-EPI timeseries and compared to SE-EPI to determine if GE-EPI's specificity to the microvascular compartment improved. To do this, functional data was collected from seven subjects on a neuro-optimized 7 T system at 800 μm isotropic resolution with both GE-EPI and SE-EPI while observing an 8 Hz contrast reversing checkerboard. Phase data from the GE-EPI was used to create a microvasculature-weighted time series (GE-EPI-PR). Anatomical imaging (MP2RAGE) was also collected to allow for surface segmentation so that the functional results could be projected onto a surface. A multi-echo gradient echo sequence was collected and used to identify venous vasculature. The GE-EPI-PR surface activation maps showed a high qualitative similarity with SE-EPI and also produced laminar activity profiles similar to SE-EPI. When the GE-EPI and GE-EPI-PR distributions were compared to SE-EPI it was shown that GE-EPI-PR had similar distribution characteristics to SE-EPI (p < 0.05) across the top 60% of cortex. Furthermore, it was shown that GE-EPI-PR has a higher contrast-to-noise ratio (0.5 ± 0.2, mean ± std. dev. across layers) than SE-EPI (0.27 ± 0.07) demonstrating the technique has higher sensitivity than SE-EPI. Taken together this evidence suggests phase regression is a useful method in low SNR studies such as high-resolution fMRI.
Interactions between Metal-binding Domains Modulate Intracellular Targeting of Cu(I)-ATPase ATP7B, as Revealed by Nanobody Binding (2014)

The biologically and clinically important membrane transporters are challenging proteins to study because of their low level of expression, multidomain structure, and complex molecular dynamics that underlies their activity. ATP7B is a copper transporter that traffics between the intracellular compartments in response to copper elevation. The N-terminal domain of ATP7B (N-ATP7B) is involved in binding copper, but the role of this domain in trafficking is controversial. To clarify the role of N-ATP7B, we generated nanobodies that interact with ATP7B in vitro and in cells. In solution NMR studies, nanobodies revealed the spatial organization of N-ATP7B by detecting transient functionally relevant interactions between metal-binding domains 1-3. Modulation of these interactions by nanobodies in cells enhanced relocalization of the endogenous ATP7B toward the plasma membrane linking molecular and cellular dynamics of the transporter. Stimulation of ATP7B trafficking by nanobodies in the absence of elevated copper provides direct evidence for the important role of N-ATP7B structural dynamics in regulation of ATP7B localization in a cell.
Rapid prototyping techniques for anatomical modelling in medicine. (1997)

The rapid advances in computer technology, often driven by the demands of industry, have created new possibilities in surgery which previous generations of surgeons could only have imagined. Improved imaging with computerised tomography (CT) has been followed by magnetic resonance imaging (MRI) and, more recently, it has become possible to reformat the data as three-dimensional images. Computer technology has new moved forward with the advent of rapid prototyping techniques (RPT) which allow both the production of models of the hard tissues and custom-made prostheses from computerised scanning data. In this article we review the development and current technologies available in RPT and the applications of this advance in surgery and illustrate this with two case reports.
Collagen–silica xerogel nanohybrid membrane for guided bone regeneration (2012)

A collagen-silica xerogel hybrid membrane was fabricated by a sol-gel process for guided bone regeneration (GBR). The silica xerogel synthesized by the sol-gel method was distributed uniformly within the collagen matrix in the form of nanoparticles. The hybridization of the silica xerogel with collagen improved the biological properties of the membrane significantly. Preosteoblast cells were observed to adhere well and grow much more actively on the hybrid membrane than on the pure collagen membrane. In particular, the hybrid membrane containing 30% of the silica xerogel showed the highest level of osteoblast differentiation. Moreover, the GBR ability, as assessed by the in vivo animal test, was superior to that of the pure collagen membrane. These findings suggest that the collagen-silica xerogel hybrid can be used as a GBR membrane.
Active crosstalk cancellation for next-generation single-ended memory interfaces (2011)

A technique to cancel forward crosstalk in densely routed, single-ended memory interfaces is presented. In this paper, the reference system bus was derived from a modern DDR3 motherboard, designed for operation at 1.6Gbps. Based on the available routing resources, the paper explores potential modifications of the main section of motherboard lines to determine if a combination of physical changes and active crosstalk cancellation can extend bus signaling rates into the next-generation. The various system configurations are compared at signaling rates up to 4.0Gbps. This crosstalk cancellation technique is evaluated by simulation.
Reducing the complexity order of position estimators with combined radiolocation measurements (2009)

As a growing attention is currently paid to low-cost energy-efficient radiolocation functionalities in a wide variety of wireless networks, one recurrent concern is to reduce the required processing time and the complexity of practical positioning estimators under deployment constraints (i.e. in terms of infrastructure, embedded computational capability and/or available measurements), while meeting simultaneously the best achievable accuracy. In this paper, we present a general method that reduces the complexity order of such position estimators with no noticeable performance degradation. The main idea consists in minimizing the number of observations that actually take part in the location computation. For this purpose, we propose to linearly combine available measurements into low-dimension observations that lead to the same Fisher Information Matrix (FIM) as that of more classical formulations (i.e. using measurements as direct observations). As an illustration, we show here how to apply this solution to two well-known position estimators, namely the linearized Least Squares (LS) estimator and the Extended Kalman Filter (EKF).
How often channel estimation is needed in MIMO systems (2003)

In this paper we develop a unique framework for evaluating the required repetition rate of channel estimation for multiple-input multiple-output (MIMO) systems in continuous fading radio channels. An analytical formula for the interference due to the temporal variation of the channel coefficients is given. This makes it possible to evaluate the time interval in which the channel has to be estimated again in order to keep the error probability below a desired threshold. This interval depends not only on the Doppler spread of the channel but also on the antenna configuration, detection algorithm and modulation scheme.
Direct reconstruction of kinetic parameter images from dynamic PET data (2005)

Our goal in this paper is the estimation of kinetic model parameters for each voxel corresponding to a dense three-dimensional (3-D) positron emission tomography (PET) image. Typically, the activity images are first reconstructed from PET sinogram frames at each measurement time, and then the kinetic parameters are estimated by fitting a model to the reconstructed time-activity response of each voxel. However, this "indirect" approach to kinetic parameter estimation tends to reduce signal-to-noise ratio (SNR) because of the requirement that the sinogram data be divided into individual time frames. In 1985, Carson and Lange proposed, but did not implement, a method based on the expectation-maximization (EM) algorithm for direct parametric reconstruction. The approach is "direct" because it estimates the optimal kinetic parameters directly from the sinogram data, without an intermediate reconstruction step. However, direct voxel-wise parametric reconstruction remained a challenge due to the unsolved complexities of inversion and spatial regularization. In this paper, we demonstrate and evaluate a new and efficient method for direct voxel-wise reconstruction of kinetic parameter images using all frames of the PET data. The direct parametric image reconstruction is formulated in a Bayesian framework, and uses the parametric iterative coordinate descent (PICD) algorithm to solve the resulting optimization problem. The PICD algorithm is computationally efficient and is implemented with spatial regularization in the domain of the physiologically relevant parameters. Our experimental simulations of a rat head imaged in a working small animal scanner indicate that direct parametric reconstruction can substantially reduce root-mean-squared error (RMSE) in the estimation of kinetic parameters, as compared to indirect methods, without appreciably increasing computation.
Oral Transmucosal Delivery of Fentanyl Citrate for Breakthrough Cancer Pain Relief (2007)

Episodes of breakthrough cancer pain are relatively common occurrences for patients undergoing cancer treatments. Characterized by pain unrestrained by traditional medications, these physical burdens impose a significant degree of suffering. In order to control and eliminate this pain, Actiq, a pharmaceutical lollipop, has been developed to provide rapid oral transmucosal delivery of fentanyl citrate, a potent medicinal narcotic. To elucidate the pharmacokinetics of the drug under various dosages, a computer model of fentanyl diffusion in the oral cavity was designed in COMSOL. Upon solving the model process, concentration profiles of fentanyl in the mucosa over time were developed for various dosages. Sensitivity analyses were also performed to determine the effects of several parameters on fentanyl diffusion. The resulting concentration profiles showed that peak concentrations of 0.00079 g/m3, 0.0016 g/m3, and 0.0032 g/m3 for 200 ?g, 400 ?g, and 800 ?g dosages, respectively, were achieved at approximately 800 seconds. Additionally, based upon the sensitivity analyses, the fentanyl solubility and the lollipop radial dissolution rate have the greatest impact on fentanyl concentration and diffusion. Future research can be performed to optimize the drug diffusion by altering these two parameters, ultimately yielding a more effective Actiq product.
Validation of Soil Moisture Data Products from the NASA SMAP Mission (2021)

NASA’s Soil Moisture Active Passive (SMAP) mission has been validating its soil moisture (SM) products since the start of data production on March 31, 2015. Prior to launch, the mission defined a set of criteria for core validation sites (CVS) that enable the testing of the key mission SM accuracy requirement (unbiased root-mean-square error &lt;0.04 m&lt;sup&gt;3&lt;/sup&gt;/m&lt;sup&gt;3&lt;/sup&gt;). The validation approach also includes other (“sparse network”) in situ SM measurements, satellite SM products, model-based SM products, and field experiments. Over the past six years, the SMAP SM products have been analyzed with respect to these reference data, and the analysis approaches themselves have been scrutinized in an effort to best understand the products’ performance. Validation of the most recent SMAP Level 2 and 3 SM retrieval products (R17000) shows that the L-band (1.4 GHz) radiometer-based SM record continues to meet mission requirements. The products are generally consistent with SM retrievals from the ESA Soil Moisture Ocean Salinity mission, although there are differences in some regions. The high-resolution (3-km) SM retrieval product, generated by combining Copernicus Sentinel-1 data with SMAP observations, performs within expectations. Currently, however, there is limited availability of 3-km CVS data to support extensive validation at this spatial scale. The most recent (version 5) SMAP Level 4 SM data assimilation product providing surface and root-zone SM with complete spatio-temporal coverage at 9-km resolution also meets performance requirements. The SMAP SM validation program will continue throughout the mission life; future plans include expanding it to forested and high-latitude regions.
P-211. Autocontrolled, randomized comparison between a tri-layer density gradient Optiprep® and the migration-sedimentation-gravity method (1999)

Abstracts of the 15th Annual Meeting of the ESHRE, Tours, France 1999 of overt hypothyroidism risks among middle-age women demanding climacteric health care.Materials and methods: Prospective analysis was carried out on well-known risk factors of developing overt hypothyroidism in women demanding climacteric health care.Raised TSH level (>5.0 mU/m!) and anti-thyroid antibody presence were evaluated in 115 women.Results: It was found that 19.1% of women demanding climacteric health care have at least one risk factor for developing overt hypothyroidism.Anti-thyroid antibody presence was the main risk factor (17.4%).Biochemical hypothyroidism (raised TSH only) was found in 3.5% of the cases.Two women had both raised TSH and anti-thyroid antibodies as risk factors. Conclusion:It was shown that one in five women attending climacteric health care is at a high risk of developing overt hypothyroidism.Since hypothyroidism may increase cardiovascular disease risk as much as oestrogen insufficiency does, it is important that climacteric services include thyroid function evaluation as routine.
Array signal processing (2001)

In this chapter, an overview of the fundamentals of array signal processing is provided with a particular emphasis on recent advances in direction-ofarrival (DOA) estimation and adaptive beamforming. It is then highlighted that the signal models used in array processing and space-time block coded MIMO communications are rather similar. At the same time, the MIMO model enjoys some interesting properties that do not emerge in classical applications of array processing. Using the established links between the aforementioned models, several important applications of array processing philosophy and concepts to point-to-point and multiuser MIMO communications are discussed.