gebhart/patrepeval huggingface dataset:
The Role of Hsp90N, a New Member of the Hsp90 Family, in Signal Transduction and Neoplastic Transformation (2002)

The 90-kDa heat shock protein (Hsp90), the target of the ansamycin class of anti-cancer drugs, is required for the conformational activation of a specific group of signal transducers, including Raf-1. In this report we have identified a 75-kDa Raf-associated protein as Hsp90N, a novel member of the Hsp90 family. Intriguingly, the ansamycin-binding domain is replaced in Hsp90N by a much shorter, hydrophobic sequence, preceded by a putative myristylation signal. We demonstrate that, although much less abundant, Hsp90N binds Raf with a higher affinity than Hsp90. In sharp contrast to Hsp90, Hsp90N does not associate with p50(cdc37), the Hsp90 kinase cofactor. Hsp90N was found to activate Raf in transiently transfected cells, while Rat F111 fibroblasts stably transfected with Hsp90N exhibited elevated activity of the Raf and downstream ERK kinases. This may be due to Raf binding to myristylated Hsp90N, followed by Raf translocation to the membrane. To examine whether Hsp90N could therefore substitute for Ras in Raf recruitment to the cell membrane, Hsp90N was transfected in c-Ras-deficient, 10T1/2-derived preadipocytes. Our results indicate that, as shown before for activated Ras or Raf, the introduction of even low levels of Hsp90N through transfection in c-Ras-deficient preadipocytes causes a dramatic block of differentiation. Higher levels of Hsp90N expression resulted in neoplastic transformation, including interruption of gap junctional, intercellular communication, and anchorage-independent proliferation. These results indicate that the observed activation of Raf by Hsp90N has a profound biological effect, which is largely c-Ras-independent. With the recent finding that p50(cdc37) is tumorigenic in transgenic mice, these results reinforce the intriguing observation that the family of heat shock proteins represents a novel class of molecules with oncogenic potential.
.sigma.-Naphthoquinodimethanes and .sigma.-phenanthroquinodimethanes. Isoindene-related species (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.sigma.-Naphthoquinodimethanes and .sigma.-phenanthroquinodimethanes. Isoindene-related speciesWilliam R. Dolbier Jr., Jean Pierre Dulcere, Simon F. Sellers, Henryk Koroniak, Blane T. Shatkin, and Thomas L. ClarkCite this: J. Org. Chem. 1982, 47, 12, 2298–2303Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://pubs.acs.org/doi/10.1021/jo00133a013https://doi.org/10.1021/jo00133a013research-articleACS PublicationsRequest reuse permissionsArticle Views811Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: STRONG BASE INDUCED CYCLOADDITION OF 3‐CARBOXY‐1‐METHYLINDOLE‐2‐ACETIC ANHYDRIDE AND 2‐CARBOXYBENZO(B)FURAN‐3‐ACETIC ANHYDRIDE: SYNTHESIS OF POLYCYCLIC PERI‐HYDROXYLATED INDOLE AND BENZOFURAN COMPOUNDS (1984)

Abstract Das in bekannter Weise erhaltene Anhydrid (I) liefert über das Anion (II) mit Dimethylenstruktur durch Addition der Acetylene (III) die entsprechenden Verbindungen (IV).
Research Advancement of Flow State in the Field of Sport (2009)

Flow state is an optimal internal experience,which is also called optimal experience in sport.It can provide optimal mental state,contribute to internal motivation,and improve efficiency,so flow state has played an important role in the development of sport psychology.The current study described the psychological characteristics,flow models,and research methods of flow state;introduced the related research such as universality of flow state,difference of flow tendency,relation of flow-performance,and influencing factors and controllability of flow state.Based on the above mentioned views,we put forward that systematic studies are necessary to examine cross-cultural similarities and differences in flow experience;improving the flow models to enrich flow theory should be a new focus;besides qualitative approaches and flow scales,increasing the possibility of flow occurring through the cognitive intervention of goal setting,and setting mediated model will be the new topics in the future.
Vacancy Migrations in Carbon Nanotubes (2008)

Activities of vacancy defects in carbon nanotubes have been directly monitored by in situ high-resolution transmission electron microscopy at elevated temperatures. Adatom-vacancy pair defects are first prolific due to the knock-on damage, and then the induced vacancies indeed grow up to 1-2 nm in the size by the following Joule heating. Surprisingly, these large vacancies, or "holes", tend to migrate and coalesce with each other to form even larger ones. It suggests that the activation barrier has been substantially lowered due to the contributions of an electromigration and/or irradiation effect.
Ischemic Neoangiogenesis Enhanced by β2-Adrenergic Receptor Overexpression (2005)

Beta2-adrenergic receptors (beta2ARs) are widely expressed, although their physiological relevance in many tissues is not yet fully understood. In vascular endothelial cells, they regulate NO release and vessel tone. Here we provide novel evidence that beta2ARs can regulate neoangiogenesis in response to chronic ischemia. We used in vivo adenoviral-mediated gene transfer of the human beta2AR to the endothelium of the rat femoral artery and increased beta2AR signaling resulting in ameliorated angiographic blood flow and hindlimb perfusion after chronic ischemia. Histological analysis confirmed that beta2AR overexpression also produced benefits on capillary density. The same maneuver partially rescued impaired angiogenesis in spontaneously hypertensive rats (SHR), whereas gene delivery of the G-protein-coupling defective mutant Ile164 beta2AR failed to provide ameliorations. Stimulation of endogenous and overexpressed beta2AR on endothelial cells in vitro was found to regulate cell number by inducing proliferation and [3H]-thymidine incorporation through means of extracellular receptor-activated kinase and vascular endothelial growth factor. The beta2AR also has novel effects on endothelial cell number through stimulation of proapoptosis and antiapoptosis pathways involving p38 mitogen-activated protein kinase and PI3-kinase/Akt activation. Therefore, beta2ARs play a critical role in endothelial cell proliferation and function including revascularization, suggesting a novel and physiologically relevant role in neoangiogenesis in response to ischemia.
Separation and sensing of whole cells using metamaterial mesh sensor with periodic microstructures (2014)

We developed metamaterial mesh sensors (MM sensors) for the detection of whole cells, such as tumor cells. In this study, we were able to capture HeLa cells (a tumor cell model) in diluted bovine blood by filtration through an MM sensor with a mesh aperture of 1.8 micro meter. Subsequently, we could detect the cells with high sensitivity from band shifts of the infrared transmittance. The surface of an MM sensor made of nickel was coated with gold (Au) using a sputtering process, resulting in enhancement of surface wetting properties and transmittance band selectivity. This treatment reduced non-specific attachment of cells on the surface, thereby improving the size selectivity of filtration. For example, due to its small size, Escherichia coli was not captured by the mesh aperture. Moreover, erythrocytes were not captured on the mesh, even though their average size is larger than the mesh aperture. On the other, HeLa cells were selectively captured from a mixture containing excess amounts of erythrocytes. These features may be beneficial for the detection of circulating tumor cells (CTCs) from patient blood samples. This improved MM sensor, which has unique optical properties that would be useful for label-free detection, could be used as a simple device for fractionating mixtures of whole cells.
Language barrier (2001)

Nurses are trying to find internationally accepted terminology to express key concepts. It is no easy task, says Anne Casey
Ethanol Production Using Concentrated Oak Wood Hydrolysates and Methods to Detoxify (1999)

Ethanol production from concentrated oak wood hydrolysate was carried out to obtain a high ethanol concentration and a high ethanol yield. The effect of added inhibitory compounds, which are typically produced in the pre-treatment step of steam-explosion on ethanol fermentation, was also examined. p-Hydroxybenzoic aldehyde, a lignin-degradation product, was the most inhibitory compound tested in this study. Compounds with additional methyl groups had reduced toxicity and the aromatic acids were less toxic than the corresponding aldehydes. The lignin-degradation products were more inhibitory than the sugar-derived products, such as furfural and 5-hydroxymethylfurfural (HMF). Adaptation of yeast cells to the wood hydrolysate and detoxification methods, such as using charcoal and overlime, had some beneficial effects on ethanol production using the concentrated wood hydrolysate. After treatment with charcoal and low-temperature sterilization, the yeast cells could utilize the concentrated wood hydrolysate with 170 as well as 140 g/L glucose, and produce 69.9 and 74.2 g/L ethanol, respectively, with a yield of 0.46–0.48 g ethanol/g glucose. In contrast, the cells could not completely utilize untreated wood hydrolysate with 100 g/L glucose. Low-temperature sterilization, with or without charcoal treatment, was very effective for ethanol production when highly concentrated wood hydrolysates were used. Low-temperature sterilization has advantages over traditional detoxification methods, such as using overlime, ion exchange, and charcoal, because of the reduction in the total cost of ethanol production.
Observation of the Atomization Process of an Intermittent Spray From a Diesel Nozzle in Its Very Early Stage. (1995)

The atomization behavior of an intermittent fuel spray from a diesel nozzle was clearly observed by means of shadowgraphy using an image-converting camera with the framing rate of 105 f.p.s. and an image-intensified CCD camera with high-speed gating. A rather wide range of valve-opening pressure (5 to 70 MPa) was covered, and simultaneous measurement of the injection pressure inside the nozzle sac was also attempted to clarify the atomization mechanisms at its very early stage of injection. At the beginning of injection, the emergence of a liquid column was observed. Initially, it has almost the same diameter as the nozzle hole and then spreads radially, forming the spray angle in the vicinity of the nozzle exit. The timing of this spray-angle formation becomes earlier with the increase in valve opening pressure, even if the pressure inside the nozzle sac at this moment does not vary. This pressure approximately corresponds to that of the transition region in an atomization regime of a steady jet.
Extreme synthesis of crystalline aerogel materials from amorphous aerogel precursors (2023)

A method includes positioning a porous structure in a pressure cell; injecting an inert pressure medium within the pressure cell; and pressurizing the pressure cell to a pressure that thermodynamically favors a crystalline phase of the porous structure over an amorphous phase of the porous structure to transition the amorphous phase of the porous structure into the crystalline phase of the porous structure.
Interpretation Of Wettability In Sandstones With Nmr Analysis (2000)

Abstract: A systematic interpretation of wettability alteration by NMR analysis was carried out on three types of sandstones with varying shalyness. Two fluid systems were investigated. Soltrol 130 was used as the refined oil. A deep water Gulf of Mexico crude oil was used as the crude oil that is known to alter the wettability in restored state core analysis. Fluids that are in molecular contact with mineral surfaces have a relaxation time that is less than the bulk fluid relaxation time due to surface relaxation phenomena. Mixed wettability can result in lengthened NMR relaxation of brine compared to 100% brine saturation and shortened NMR relaxation of oil compared to bulk oil when oil becomes in contact with part of the rock surfaces. Thus, NMR T1 relaxation time distribution provides qualitative description of wettability alteration. Bentheim and Berea were water-wet with refined oil. When saturated with crude oil and brine at Swir they became mixed-wet after aging. After forced imbibition, apparently patches of crude oil remained on the rock surfaces because the residual oil had a shorter relaxation time compared to the bulk oil. North Burbank sandstone was mixed-wet when either saturated with refined oil at Swir or crude oil after aging. Micropores formed by chlorite flakes were filled with brine. Oil in the macropores was in contact with the tips of chlorite flakes. After forced imbibition, brine in the macropores was partially shielded from the pore walls by a film of oil spanning the tips of chlorite clays. The evidence for this was that macro-brine relaxed slower than 100% brine saturation but faster than bulk brine and oil relaxed faster than bulk oil. Thus North Burbank appeared mixed-wet with either refined oil or with crude oil. However, the extent of wetting change was greater with crude oil. This special wetting behavior of North Burbank came from its microporous structure formed by pore-lining chlorite flakes. The spontaneous imbibition and forced imbibition wettability test proposed by Amott provides a measurement of wettability. North Burbank sandstone had little spontaneous imbibition with either refined oil or crude oil. Bentheim and Berea sandstones had spontaneous imbibition with refined oil while only Berea had small amount of spontaneous imbibition with crude oil. Residual oil saturation estimate provides another quantitative indication of wettability alteration. For both refined oil and crude oil systems, North Burbank has significantly less residual oil saturation than that estimated from counter current imbibition. This further confirms that North Burbank was mixed-wet with Soltrol and this crude oil. Berea has the highest residual oil saturation and exhibits about 10 percent reduction of Sor from refined oil to crude oil.
Amino acid motifs in both the major and minor capsid proteins of HPV51 impact antigenicity and infectivity (2015)

Persistent infection with oncogenic human papillomavirus (HPV) is a prerequisite for cervical disease development, yet data regarding the host immune response to infection at the genotype level are quite limited. We created pseudoviruses bearing the major (L1) and minor (L2) capsid proteins and L1 virus-like particles representing the reference sequence and a consensus of 34 European sequences of HPV51. Despite the formation of similarly sized particles, motifs in the reference L1 and L2 genes had a profound impact on the immunogenicity, antigenicity and infectivity of these antigens. The antibody status of women exhibiting low-grade disease was similar between HPV16 and the consensus HPV51, but both demonstrated discrepancies between binding and neutralizing antibody responses. These data support the use of pseudoviruses as the preferred target antigen in studies of natural HPV infection and the need to consider variation in both the L1 and L2 proteins for the appropriate presentation of antibody epitopes.
The chromatic input to global motion perception (2003)

For over 30 years there has been a controversy over whether color-defined motion can be perceived by the human visual system. Some results suggest that there is no chromatic motion mechanism at all, whereas others do find evidence for a purely chromatic motion mechanism. Here we examine the chromatic input to global motion processing for a range of color directions in the photopic luminance range. We measure contrast thresholds for global motion identification and simple detection using sparse random-dot kinematograms. The results show a discrepancy between the two chromatic axes: whereas it is possible for observers to perform the global motion task for stimuli modulated along the red-green axis, we could not assess the contrast threshold required for stimuli modulated along the yellowish-violet axis. The contrast required for detection for both axes, however, are well below the contrasts required for global motion identification. We conclude that there is a significant red-green input to global motion processing providing further evidence for the involvement of the parvocellular pathway. The lack of S-cone input to global motion processing suggests that the koniocellular pathway mediates the detection but not the processing of complex motion for our parameter range.
Summary of the 1993 ASHG ancillary meeting “recent research on chromosome 4p syndromes and genes” (1995)

The following is a summary of presentations given during an ancillary meeting to the 1993 American Society of Human Genetics Meeting in New Orleans, LA. This ancillary meeting, entitled "Recent Research on Chromosome 4p Syndromes and Genes," reviewed the history of the Wolf-Hirschhorn syndrome (WHS), the natural history of patients with WHS, and the smallest region of deletion associated with the WHS. The proximal 4p deletion syndrome and the duplication 4p syndrome were also described and advice was offered regarding detection of chromosome 4p deletions, duplications, and rearrangements. The current status of the physical map of chromosome 4p with emphasis on the genes that map to the 4p16 region was presented along with a preliminary phenotypic map of 4p16. The goal of this format was to provide a comprehensive review of the clinical presentations, diagnostic capabilities, and genetic mapping advances involving chromosome 4p.
A new on-line cash check scheme (1997)

Article A new on-line cash check scheme Share on Authors: Robert H. Deng Institute of Systems Science, National University of Singapore, Singapore Institute of Systems Science, National University of Singapore, SingaporeView Profile , Yongfei Han Institute of Systems Science, National University of Singapore, Singapore Institute of Systems Science, National University of Singapore, SingaporeView Profile , Albert B. Jeng Institute of Systems Science, National University of Singapore, Singapore Institute of Systems Science, National University of Singapore, SingaporeView Profile , Teow-Hin Ngair Institute of Systems Science, National University of Singapore, Singapore Institute of Systems Science, National University of Singapore, SingaporeView Profile Authors Info & Claims CCS '97: Proceedings of the 4th ACM conference on Computer and communications securityApril 1997 Pages 111–116https://doi.org/10.1145/266420.266444Online:01 April 1997Publication History 7citation718DownloadsMetricsTotal Citations7Total Downloads718Last 12 Months6Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients (2013)

Dermatologic Principles And Practice In Oncology. Conditions Of The Skin, Hair, And Nails In Cancer Patients - Libros de Medicina - Dermatologia Oncologica - 120,60
K2 Toxicity: Fatal Case of Psychiatric Complications Following AM2201 Exposure (2013)

Limited forensic and clinical experience and the lack of confirmatory testing strategies for synthetic cannabinoids (SC) prevent adequate characterization of SC toxicity and the potential impact on public health. A statewide surveillance system identified a fatality involving a 23-year-old man found with a large stab wound to the neck following use of a SC product suspected of containing AM2201. Analytical testing for common SCs, SC metabolites, routine drugs of abuse, and over-the-counter medications was performed on heart blood obtained at autopsy. Additionally, assays were performed on the SC raw material and drug paraphernalia found on the decedent. High concentrations of AM2201 were detected in all samples. AM2201 metabolites were detected in postmortem blood. Other than a trace amount of JWH-073 found in smoke residue, no other substances were detected. Psychiatric complications including self-induced, lethal trauma can occur after the use of SC products.
High-Resolution 3D Diffusion Tensor Measurements of Japanese Quail Embryos (2003)

M. Martin, S. W. Ruffins, R. Lansford, J. M. Tyszka, R. E. Jacobs Caltech, Pasadena, CA, United States Synopsis Diffusion tensor measurements (1) made from high-resolution (100-250 μm isotropic) 3D ultra-fast low-angle rapid acquisition and relaxation enhancement (UFLARE) (2) images are compared and contrasted to T2-weighted UFLARE images of in vivo and ex vivo Japanese quail embryos. The diffusion images exhibit more contrast between the central nervous system (CNS) and the rest of the body. Structures within the CNS, eyes, and many organs are more easily recognized with DTI than with T2 imaging because of their anisotropy. Such images can be used in a 3D interactive atlas of quail development to follow the normal and irregular development of the quail embryo.
The Future of the University of Pittsburgh Medical Center: Strategic Planning with the Analytic Network Process (1996)

This paper summarizes the research and analysis used to determine the best strategy(s) for the University of Pittsburgh Medical Center(UPMC) to implement in order to become more competitive in' a managed care environment. The study employs the Analytic Network Process (ANP) feedback modeling technique to analyze the benefits, costs and risks of five major strategic options available to UPMC. The ANP tool incorporates the interdependent influences that often exisebetween systemic variables. The findings suggest that UPMC should concentrate most on improving patient satisfaction and thereby the number of patients. UPMC should also develop a primary care network so that the hospital complex can attract more patients through referrals from affiliates.
Uncertainty Characterisation & Validation within ESA Fire-CCI (2018)

Uncertainty characterisation and validation are critical phases to generate any Essential Climate Variable (ECV), and therefore both have been included as key deliverables of the ESA CCI programme [1]. All products generated by the CCI are required to have an associated per pixel uncertainty characterisation. This paper describes both the uncertainty characterisation framework and the related uncertainty validation exercise of the Fire-CCI project.