gebhart/patrepeval huggingface dataset:
Analysis of Ciprofloxacin by a Simple High-Performance Liquid Chromatography Method (2008)

A simple and sensitive high-performance liquid chromatographic method is described for the quantitative analysis of ciprofloxacin in pharmaceuticals and human plasma. The method employs reversed-phase chromatography using an RP-C18 column with an isocratic mobile phase of acetonitrile-2% acetic acid aqueous solution (16:84, v/v), umbelliferone as an internal standard, and a flow rate of 1.0 mL/min. The UV detector is set at 280 nm. The limit of detection is 0.25 microM (S/N = 3, injection volume = 10 microL). The regression equations are linear (r > 0.9999) over a range between 0.51 approximately 130 microM for the pharmaceutical analysis of ciprofloxacin and 0.51 approximately 64.8 microM for the biological analysis of ciprofloxacin in human plasma. The intra- and inter-day relative standard deviation and relative error are less than 3.39% and 5.71%, respectively. All the recoveries are greater than 93.8%. This method is successfully applied in a pharmacokinetic study of a volunteer who receives a 500 mg ciprofloxacin tablet.
Corrigendum: Total Synthesis of Tryprostatins A and B (2014)

Some of the NMR spectra shown in the Supporting Information of this manuscript have not been properly processed. Copies of the correct spectra are available as Supporting Information for this Corrigendum. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Construction of a brain-machine hybrid system to analyze adaptive behavior of silkworm moth (2010)

We have created a brain-machine hybrid system (BMHS) which is able to solve the chemical plume tracking (CPT) problem using the brain of the male silkworm moth. The purpose of the system is to investigate adaptability which results from interactions between brain, body, and environment. In this paper, we describe a BMHS architecture and experiments to verify that the behavior of the BMHS is similar to that of a silkworm moth. The BMHS is a kind of cyborg system in which the body of a living being is replaced by a mobile robot and the organism's brain is used to control the robot. The artificial body is controlled by motor commands for the original body that are extracted from a signal recorded from the brain. For that purpose, a small measurement system to record signals was created and a method to reconstruct the motor commands from the signals was established. We demonstrate that the BMHS can behave like a silkworm moth. We compared the trajectories of moths with the trajectories of the BMHS incorporating the same individual moths. Through the experiments we confirmed that the system can solve the CPT problem. Our system has the potential to reveal principles of adaptability in silkworm moth behavior.
Band Gap Modification of Diamond Photonic Crystals by Changing the Volume Fraction of the Dielectric Lattice (2003)

Photonic crystals with a diamond structure of epoxy lattices in which TiO 2 ‐based ceramic particles are dispersed were fabricated by stereolithography. The periodicity of the lattice was designed to reflect electromagnetic waves in the gigahertz range. The volume fraction (β) of the dielectric lattice medium was modified from 14% to 33% by changing the rod diameter of the lattice. The photonic band gap was observed along Γ‐L 〈111〉, Γ‐X 〈100〉, and Γ‐K 〈110〉 directions and the complete photonic band gap was formed at over β= 20%. The width of the forbidden gap increased gradually when the β increased over 14%, and reached 2.4 GHz at β= 33%. These results agreed with the band calculation using the plane wave expansion method.
Separating bulk from grain boundary Li ion conductivity in the sol–gel prepared solid electrolyte Li1.5Al0.5Ti1.5(PO4)3 (2015)

Impedance spectroscopy measurements down to very low temperatures allowed for resolving bulk ion transport properties in highly conducting ceramic electrolytes.
Synthesis of dual-functional poly(6-azidohexylmethacrylate) brushes by a RAFT agent carrying carboxylic acid end groups (2015)

Novel types of dual-functional surface-attached polymer brushes were developed by interface-mediated reversible addition-fragmentation chain transfer (RAFT) polymerization of 6-azidohexylmethacrylate using the surface-immobilized RAFT agent and the free initiator. The interface-mediated RAFT polymerization produced silicon substrate coated with dual-functional (azido groups from monomer and carboxylic acid groups from RAFT agent) poly(6-azidohexylmethacrylate) [poly (AHMA)] with a grafting density as high as 0.59 chains/nm2. Dual-functional polymer brushes can represent an attractive chemical platform to deliberately introduce other molecular units at specific sites. The azido groups of the poly(AHMA) brushes can be modified with alkyl groups via click reaction, known for their DNA hybridization, while the carboxylic acid end groups can be reacted with amine groups via amide reaction, known for their antifouling properties. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 1696–1706
Identification and validation of cognitive design principles for automated generation of assembly instructions (2004)

Designing effective instructions for everyday products is challenging. One reason is that designers lack a set of design principles for producing visually comprehensible and accessible instructions. We describe an approach for identifying such design principles through experiments investigating the production, preference, and comprehension of assembly instructions for furniture. We instantiate these principles into an algorithm that automatically generates assembly instructions. Finally, we perform a user study comparing our computer-generated instructions to factory-provided and highly rated hand-designed instructions. Our results indicate that the computer-generated instructions informed by our cognitive design principles significantly reduce assembly time an average of 35% and error by 50%. Details of the experimental methodology and the implementation of the automated system are described.
Bit Performance Evaluation Revisited by Means of Bit Index and Formation Drillability Catalogue (2007)

Abstract The paper is aimed to calculate an innovative numerical index for bit performance evaluation called Bit Index (BI), applied on a new type of formation and bit database also known as Formation Drillability Catalogue (FDC). A dedicated research program developed by Eni E&amp;P Div. and the University of Bologna (Italy) studied a drilling model for drill-bit performance evaluation (the BI) derived from data recorded while drilling (bit records, master log, wireline log, etc.) that includes numerical information from dull bit evaluation. This index is calculated with data collected inside the FDC, a novel classification of formations aimed to the geotechnical and geomechanical characterization and subdivisions of the formations, called Minimum Interval (MI). FDC was conceived and prepared at Eni E&amp;P Div., and contains a large number of significant drilling parameters. Some wells have been identified inside the FDC and have been tested for bit performance evaluation. The values of BI are calculated for each bit run and are compared with the values of the cost per meter. The case study analyzes bits of the same typology and run in the same formation. The BI methodology implemented on MI classification of FDC can improve consistently the bit performances evaluation, and it helps to identify the best performer bits. Moreover, FDC turned out to be particularly functional to BI, since it discloses and organizes many formation details that are not easily detectable or usable from bit records or master logs, allowing for targeted bit performance evaluations. At this stage of development, the BI methodology proved to be economic and reliable, helping as well to make drill bit selection less erroneous and more logical.
Effect of phospholipids on conformational change and heat stability of ovalbumin. Circular dichroism and nuclear magnetic resonance studies (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of phospholipids on conformational change and heat stability of ovalbumin. Circular dichroism and nuclear magnetic resonance studiesYoshinori. Mine, Kazuhiro. Chiba, and Masahiro. TadaCite this: J. Agric. Food Chem. 1993, 41, 2, 157–161Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/jf00026a002https://doi.org/10.1021/jf00026a002research-articleACS PublicationsRequest reuse permissionsArticle Views222Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the mechanism of ligand-induced down-regulation of insulin receptor level in the liver cell. (1981)

Exposure of chick liver cells in monolayer culture to
Enhydrazine, I. Acylierung von tautomeriefähigen Enhydrazinen (1982)

Abstract Durch Acylierung der Enhydrazinocarbonsäure‐ester und ‐amide 1, 6, 8 und 10 mit Carbonsäurechloriden, Sulfensäurechloriden oder Iso(thio)cyanaten werden die C ‐Acylierungsprodukte 3, 5, 7, 9, 12 und 14 erhalten. Die Enhydrazinocarbonitrile 16 und 19 reagieren mit Carbonsäurechloriden unter Ringschluß zu den 5‐(Acylamino)pyrazolderivaten 18 und 21. Einige spektroskopische Daten der Reaktionsprodukte werden angegeben.
Panel on future challenges in modeling methodology (2004)

This panel paper presents the views of six researchers and practitioners of simulation modeling. Collectively we attempt to address a range of key future challenges to modeling methodology. It is hoped that the views of this paper, and the presentations made by the panelists at the 2004 Winter Simulation Conference will raise awareness and stimulate further discussion on the future of modeling methodology in areas such as modeling problems in business applications, human factors and geographically dispersed networks; rapid model development and maintenance; legacy modeling approaches; markup languages; virtual interactive process design and simulation; standards; and Grid computing.
Homopolymer and small‐molecule tracer diffusion in a gyroid matrix (2001)

Abstract Forced Rayleigh scattering was used to measure the tracer diffusion coefficients of the photochromic dye tetrathioindigo (TTI) and a 1,4‐polyisoprene (PI) homopolymer (8000 g/mol) in a poly(styrene‐ b ‐isoprene) (SI) diblock copolymer matrix that formed a bicontinuous gyroid microstructure. The diblock copolymer contained 63% polystyrene (PS) by volume and had a total molecular weight of 21,300 g/mol. Rheology and small‐angle X‐ray scattering confirmed that the diblock copolymer microphase‐separated into the bicontinuous gyroid over the temperature range 60–230 °C, where the sample disordered. For both the TTI and PI tracers, two distinct modes of transport were observed. The faster mode displayed a temperature dependence consistent with diffusion within a PI matrix, whereas the slower mode had a temperature dependence more similar to diffusion within PS. The fast diffusivities were both over an order of magnitude lower than in a corresponding PI homopolymer matrix. For TTI, this was attributed to the preferential selectivity of the dye for PS and, therefore, an averaging of the mobility between the PS and PI domains. The slow mode was consistent with a small fraction of the TTI dye molecules becoming trapped within the much slower PS domains. For the PI tracer, the reduction in the diffusion coefficient for the fast mode was attributed to a combination of the tortuosity of the struts, the suppression of constraint release within the diblock matrix, and additional friction due to the presence of some styrene segments within the PI domains. The inevitable presence of grain boundaries or defects within the matrix interrupted the percolation of the PI struts, thereby forcing some of the PI tracers to diffuse through PS. Consequently, the slow mode was attributed to the diffusion through these defects, where the PI diffusion was retarded by both the increased segmental friction and the thermodynamic barrier to entering the PS domains. © 2001 John Wiley &amp; Sons, Inc. J Polym Sci B: Polym Phys 39: 843–859, 2001
CNS1 Encodes an Essential p60/Sti1 Homolog in Saccharomyces cerevisiae That Suppresses Cyclophilin 40 Mutations and Interacts with Hsp90 (1998)

Cyclophilins are cis-trans-peptidyl-prolyl isomerases that bind to and are inhibited by the immunosuppressant cyclosporin A (CsA). The toxic effects of CsA are mediated by the 18-kDa cyclophilin A protein. A larger cyclophilin of 40 kDa, cyclophilin 40, is a component of Hsp90-steroid receptor complexes and contains two domains, an amino-terminal prolyl isomerase domain and a carboxy-terminal tetratricopeptide repeat (TPR) domain. There are two cyclophilin 40 homologs in the yeast Saccharomyces cerevisiae, encoded by the CPR6 and CPR7 genes. Yeast strains lacking the Cpr7 enzyme are viable but exhibit a slow-growth phenotype. In addition, we show here that cpr7 mutant strains are hypersensitive to the Hsp90 inhibitor geldanamycin. When overexpressed, the TPR domain of Cpr7 alone complements both cpr7 mutant phenotypes, while overexpression of the cyclophilin domain of Cpr7, full-length Cpr6, or human cyclophilin 40 does not. The open reading frame YBR155w, which has moderate identity to the yeast p60 homolog STI1, was isolated as a high-copy-number suppressor of the cpr7 slow-growth phenotype. We show that this Sti1 homolog Cns1 (cyclophilin seven suppressor) is constitutively expressed, essential, and found in protein complexes with both yeast Hsp90 and Cpr7 but not with Cpr6. Cyclosporin A inhibited Cpr7 interactions with Cns1 but not with Hsp90. In summary, our findings identify a novel component of the Hsp90 chaperone complex that shares function with cyclophilin 40 and provide evidence that there are functional differences between two conserved sets of Hsp90 binding proteins in yeast.
1H and 13C chemical shifts of some 1, 2‐Dithiole‐3‐thione derivatives (1989)

Abstract The 1 H and 13 C NMR signals for some 1,2‐dithiole‐3‐thiones, their intermediates and derivatives have been assigned.
<title>0.35-um i-line poly processing with a bottom antireflective coating (BARC)</title> (1995)

The manufacturing of high performance integrated circuits requires tight control of critical dimensions (CD) at poly pattern. Achieving these CD requirements forces process engineers to eliminate linewidth variation caused by reflective notching and thin film effects. Implementation of a bottom antireflective coating (BARC) can reduce or eliminate linewidth variations caused by reflective notching and thin film effects. With the additional process complexity, a number of issues must be resolved to obtain the true benefits of using a BARC material. The following paper discusses the characterization of a commercially available BARC material for 0.35 micrometers i-line poly patterning. Initial characterization of gratings and isolated lines on flat poly test wafers shows the resist process with BARC to have equal and in some cases better process capability compared to a conventional resist process. An 800 angstrom BARC film thickness on flat silicon wafers reduces the amplitude of the resist swing curve by 75%. On topography wafers an 800 angstrom BARC thickness eliminates reflective notching although for some small feature sizes, thin film effects still cause linewidth nonuniformity. Evaluations of BARC thicknesses ranging from 800 angstrom to 2,400 angstrom demonstrate the capability of the BARC to eliminate the swing effect in the resist by optimization of the BARC thickness. Cross sections of the resist profiles before and after etch demonstrate the ability for a repeatable pattern transfer. Wafer-to-wafer data and lot- to-lot data show the successful development of an etch process with a 0.03 micrometers bias. The data presented demonstrates the implementation of an optimized BARC process enhances the CD control capability at poly patterning for 0.35 micrometers i-line processing.
Biotinyl-Tyrosine-Glycine-CCK as a functional probe of high and low affinity CCK-A receptors in rat pancreatic acini (1990)

info:eu-repo/semantics/published
Modeling and measurements of anode cover behavior inside aluminum electrolysis cells (2015)

ABSTRACTA model for predicting anode cover behavior inside aluminum electrolysis cells is presented. The model predicts the transformation of anode cover material into a solid crust, the melting/solidification of the bath and crust, and the heat fluxes escaping the anode cover. The model is validated with experimental data taken on industrial electrolysis cells. The temperature and positions of the top crust, the heat flux escaping the anode cover, and the height of the cavity are presented, along with the model predictions. The effect of bath temperature on the crust formation is further investigated. Results show that the bath temperature can greatly enhance the rate of crust formation. NomenclatureA=frequency factor [s−1]ACM=anode cover materialASD=anode to sidewall distance [m]As=cross section of the anode or stubs [m2]CA=concentration of reactant A [mol/l]CFD=Computational Fluid DynamicsCp=specific heat [J/kg · K]CR=cryolite ratiodt=time step [s]dx=space step [m]dy=space step [m]Ea=energy of activation [J/mol]f=liquid fractionh=heat transfer coefficient [W/m2 · K]I=electrical current [A]k=thermal conductivity [W/m · K]kA=reaction rate constant [s−1]n=number of moles [mol]=thermo-electric Joule effect [W/m3]q″=heat flux [W/m2]R=universal gaz constant [J/mol · K]t=time [s]T=temperature [K]V=volume [m3]x=space direction [m]X=conversiony=space direction [m]α=thermophysical properties [kg/m3, W/m · K, J/kg · K, J/kg]δH=volumetric enthalpy change [J/m3]λ=heat of fusion [J/kg]ρ=density [kg/m3]ρΩ=electrical resistivity [Ω · m]Ω=boundarySubscripts= ∞ =ambientliq=liquidusliquid=liquid state0=initialsol=solidussolid=solid stateNomenclatureA=frequency factor [s−1]ACM=anode cover materialASD=anode to sidewall distance [m]As=cross section of the anode or stubs [m2]CA=concentration of reactant A [mol/l]CFD=Computational Fluid DynamicsCp=specific heat [J/kg · K]CR=cryolite ratiodt=time step [s]dx=space step [m]dy=space step [m]Ea=energy of activation [J/mol]f=liquid fractionh=heat transfer coefficient [W/m2 · K]I=electrical current [A]k=thermal conductivity [W/m · K]kA=reaction rate constant [s−1]n=number of moles [mol]=thermo-electric Joule effect [W/m3]q″=heat flux [W/m2]R=universal gaz constant [J/mol · K]t=time [s]T=temperature [K]V=volume [m3]x=space direction [m]X=conversiony=space direction [m]α=thermophysical properties [kg/m3, W/m · K, J/kg · K, J/kg]δH=volumetric enthalpy change [J/m3]λ=heat of fusion [J/kg]ρ=density [kg/m3]ρΩ=electrical resistivity [Ω · m]Ω=boundarySubscripts= ∞ =ambientliq=liquidusliquid=liquid state0=initialsol=solidussolid=solid stateAcknowledgmentsThe authors would like to thank the CRDA reduction technicians team and the personnel of Usine Grande-Baie for their valuable help during the course of the measurement campaigns.
Les échanges d'acides aminés entre plasma et globules rouges : étude in vivo chez l'homme par les isotopes stables (1988)

homme par les isotopes stables, par
Temperature dependence of chromatic dispersion in various types of optical fiber (2000)

The temperature dependence of chromatic dispersion is examined for various types of fiber. Its coefficient is found to depend strongly on the dispersion slope. Dispersion-flattened fiber has a significantly low coefficient of -0.0005(ps/nm/km)/ degrees C , compared with -0.0038(ps/nm/km)/ degrees C for large-core nonzero dispersion-shifted fiber. Transmission lines with low dispersion slopes consisting of pure silica core fiber and dispersion-compensating fiber also exhibit low coefficients of less than -0.001(ps/nm/km)/ degrees C because of their compensating effects.
ChemInform Abstract: Structural Dynamics of Carbon and Metal Containing Carbon Clusters (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High Frequency Electroporation for Cancer Therapy (2011)

Electroporation is a non-linear biophysical mechanism in which the application of an external pulsed electric field leads to an increase in the permeability of cellular membranes. The extent of electroporation is attributed to the induced buildup of charge across the membrane, and consequently, transmembrane potential (TMP). Increasing the TMP has been described to produce various permeabilizing effects, wherein the formation of hydrophilic, aqueous pores becomes energetically favorable [1]. If the pulse parameters are tuned such that the membrane defects are only temporary, and the cell remains viable, the process is termed reversible electroporation. As a cancer therapy, reversible electroporation has been employed to increase the cellular uptake of chemotherapeutic drugs. Irreversible electroporation (IRE) results when membrane defects are permanent, leading to cell death. Recently, IRE has been recognized as an independent means to destroy tumors without the use of adjuvant drugs and prior to the onset of thermal injury [2].
TREM-1 expression during major abdominal surgery: Comment on the Gonzalez-Roldan et al paper (2006)

TREM-1 expression during major abdominal surgery: Comment on the Gonzalez-Roldan et al paper