gebhart/patrepeval huggingface dataset:
Enhancement of the osteogenic efficacy of osteoblast transplantation by the sustained delivery of basic fibroblast growth factor (2006)

Abstract Previously, the sustained delivery of basic fibroblast growth factor (bFGF) has been demonstrated to promote bone regeneration in bone defects that had not been treated with osteogenic cell transplantation. In this study, we tested the hypothesis that the sustained delivery of bFGF could enhance osteoblast transplantation‐mediated ectopic bone formation. Rat osteoblasts and bFGF were mixed with an injectable fibrin matrix and subcutaneously transplanted to rats (cell + bFGF group). The fibrin matrix played roles in both the cell transplantation matrix and the bFGF sustained delivery matrix. The transplantation of osteoblasts suspended in a fibrin matrix without bFGF served as a control. Twelve weeks after transplantation, histological analyses of retrieved transplants showed that new bone formation was more abundant and mature in the cell + bFGF group than in the control group. The bone formation area and the calcium content in the cell + bFGF group were two‐ and nine‐fold higher, respectively, than those in the control group. Enhanced bone formation by the sustained delivery of bFGF may be attributed to the enhanced osteogenic gene expression of the transplanted cells and neovascularization of the transplants, as both mRNA expression of various osteogenic markers and arteriole density in the cell + bFGF group were significantly higher than those in the control group. This study demonstrates that the sustained delivery of bFGF can potentiate ectopic bone regeneration by osteoblast transplantation. This combination therapy may have effective implications for bone regeneration in large bone defects in which extensive osteogenic cell migration and angiogenesis are required. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006
Phosphorylation of Focal Adhesion Kinase (FAK) on Ser732 Is Induced by Rho-dependent Kinase and Is Essential for Proline-rich Tyrosine Kinase-2–mediated Phosphorylation of FAK on Tyr407 in Response to Vascular Endothelial Growth Factor (2006)

Focal adhesion kinase (FAK) is phosphorylated on tyrosine and serine residues after cell activation. In the present work, we investigated the relationship between tyrosine and serine phosphorylation of FAK in promoting endothelial cell migration in response to vascular endothelial growth factor (VEGF). We found that VEGF induces the activation of the Rho-dependent kinase (ROCK) downstream from vascular endothelial growth factor receptor (VEGFR) 2. In turn, activated ROCK directly phosphorylates FAK on Ser732. Proline-rich tyrosine kinase-2 (Pyk2) is also activated in response to VEGF. Its activation requires the clustering of integrin alphavbeta3 and triggers directly the phosphorylation of Tyr407 within FAK, an event necessary for cell migration. Interestingly, ROCK-mediated phosphorylation of Ser732 is essential for Pyk2-dependent phosphorylation of Tyr407, because the latter is abrogated in cells expressing a FAK mutant that is nonphosphorylatable on Ser732. We suggest that VEGF elicits the activation of the VEGFR2-ROCK pathway, leading to phosphorylation of Ser732 within FAK. In turn, phosphorylation of Ser732 would change the conformation of FAK, making it accessible to Pyk2 activated in response to its association with integrin beta3. Then, activated Pyk2 triggers the phosphorylation of FAK on Tyr407, promoting cell migration.
Major histocompatibility complex products restrict the adherence of cytolytic T lymphocytes to minor histocompatibility antigens or to trinitrophenyl determinants on schistosomula of Schistosoma mansoni. (1979)

We have previously shown that schistosomula passaged through mice acquire histocompatibility (H) antigens that can be recognized either by alloantibody or by alloreactive cytolytic T lymphocytes (CTL). The latter specifically adhere to but fail to damage the parasite. In this paper we describe the use of trinitrophenyl (TNP)-labeled schistosomula to show that the adherence of CTL with specificity for TNP-modified syngeneic cells is restricted by the major histocompatibility complex (MHC) in a fashion similar to that seen in the lysis of TNP-labeled tumor targets. Thus, these CTL adhere only to schistosomula that have both the appropriate H antigens and TNP determinants on their surface, and not to schistosomula bearing either of these antigens by themselves. We note a significant degree of adherence to schistosomula bearing TNP determinants and H antigens allogeneic to the CTL. Anti-minor H antigen CTL are also restricted by the MHC in their adherence; thus, they only adhere to schistosomula that carry both the major and minor H antigens of the stimulator cells. These antigens can be acquired either by a single passage in vivo of schistosomula through congenic strains that possess both the relevant antigens or by sequential passage through two different strains, each contributing one of the antigens in question.
A Closer Look at the Passivity and Transpassive Dissolution of Chromium Using Atomic Spectroelectrochemistry (2022)

The dissolution and growth kinetics of the passive film upon chromium (Cr) in 0.1 M NaCl was studied using atomic spectroelectrochemistry. The dissolution rate was independent of applied potential in the passive region, and increased exponentially with increasing potential in the transpassive region. The growth kinetics of the passive film upon Cr in the passive state was consistent with the assumptions of the point defect model. The charge balance analysis established an intermediate potential region whereby the growth rate of Cr2O3 layer was higher than the dissolution rate in the transpassive state. The interdependence of oxidation and dissolution rate of Cr in non-steady state was revealed and its significance to the passivity of Cr-containing alloys was discussed.
ACOFT ANZCOP SPIE Melb 2019 RF frequency converter (2020)

A broadband microwave mixer is demonstrated based on an integrated optical micro-comb source, with an operationbandwidth up to over 60 GHz, a conversion efficiency of −6.8 dB and a spurious suppression ratio of over 43.5 dB, andexperimentally verify the RF performance up to 40 GHz. This approach to realizing microwave mixers offers reducedcomplexity, size, and potential cost for a wide range of applications to microwave systems.
Caractérisation Load-Pull d'un amplificateur de puissance (2011)

International audience
Synthesis of Pyrroloquinolinequinone Analogs. Molecular Structure and Moessbauer and Magnetic Properties of Their Iron Complexes (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Pyrroloquinolinequinone Analogs. Molecular Structure and Moessbauer and Magnetic Properties of Their Iron ComplexesL. Tommasi, L. Shechter-Barloy, D. Varech, J.-P. Battioni, B. Donnadieu, M. Verelst, A. Bousseksou, D. Mansuy, and J.-P. TuchaguesCite this: Inorg. Chem. 1995, 34, 6, 1514–1523Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/ic00110a033https://doi.org/10.1021/ic00110a033research-articleACS PublicationsRequest reuse permissionsArticle Views164Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Wideband RWG-SIW Interconnection With Improved Integration for Millimeter-Wave/Terahertz Application (2022)

In this letter, wideband interconnections are proposed to connect metal rectangular waveguide (RWG) and substrate integrated waveguide (SIW) based on printed circuit board (PCB) technology. For the purpose of easy fabrications and micro-assembly processes in millimeter-wave/terahertz (MMW/THz) applications, a standard RWG is used to feed the transition without any manufactures in the metal waveguide. The wideband interconnection structure with improved impedance matching is only designed in a single-layer PCB. Particularly, the novel interconnections are realized by stepped dielectric transformers using PCB technology. These integrations have the advantages of simple structure, low fabrication cost, and easy processes. To demonstrate the scheme, two 220-GHz band interconnections are designed as examples. Back-to-back interconnections are fabricated and measured. The measured results agree well with the simulated results. It can be concluded that the measured insertion and return losses of both single interconnections are better than 0.9 and 10 dB, respectively, in the frequency range from 180 to 240 GHz (28.6%).
The Use of Comparative Genomic Analysis for the Development of Subspecies-Specific PCR Assays for Mycobacterium abscessus (2022)

<i>Mycobacterium abscessus</i> complex (MABC) is an important pathogen of immunocompromised patients. Accurate and rapid determination of MABC at the subspecies level is vital for optimal antibiotic therapy. Here we have used comparative genomics to design MABC subspecies-specific PCR assays. Analysis of single nucleotide polymorphisms and core genome multilocus sequence typing showed clustering of genomes into three distinct clusters representing the MABC subspecies <i>M. abscessus</i>, <i>M. bolletii</i> and <i>M. massiliense</i>. Pangenome analysis of 318 MABC genomes from the three subspecies allowed for the identification of 15 MABC subspecies-specific genes. <i>In silico</i> testing of primer sets against 1,663 publicly available MABC genomes and 66 other closely related <i>Mycobacterium</i> genomes showed that all assays had >97% sensitivity and >98% specificity. Subsequent experimental validation of two subspecies-specific genes each showed the PCR assays worked well in individual and multiplex format with no false-positivity with 5 other mycobacteria of clinical importance. In conclusion, we have developed a rapid, accurate, multiplex PCR-assay for discriminating MABC subspecies that could improve their detection, diagnosis and inform correct treatment choice.
A Molecular Plug−Socket Connector (2007)

A monocationic plug-socket connector that is composed, at the molecular level, of three components, (1) a secondary dialkylammonium center (CH2NH2+CH2), which can play the role of a plug toward dibenzo[24]crown-8 (DB24C8), (2) a rigid and conducting biphenyl spacer, and (3) 1,4-benzo-1,5-naphtho[36]crown-10 (BN36C10), capable of playing the role of a socket toward a 4,4'-bipyridinium dicationic plug, was synthesized and displays the ability to act as a plug-socket connector. The fluorescent signal changes associated with the 1,5-dioxynaphthalene unit of its BN36C10 portion were monitored to investigate the association of this plug-socket connector with the complementary socket and plug compounds. The results indicate that (1) the CH2NH2+CH2 part of the molecular connector can thread DB24C8 in a trivial manner and (2) the BN36C10 ring of the connector can be threaded by a 1,1'-dioctyl-4,4'-bipyridinium ion only after the CH2NH2+CH2 site is occupied by a DB24C8 ring. The two connections of the three-component assembly are shown to be controlled reversibly by acid/base and red/ox external inputs, respectively. The results obtained represent a key step for the design and construction of a self-assembling supramolecular system in which the molecular electron source can be connected to the molecular electron drain by a molecular elongation cable.
Chlamydia trachomatisProctitis (1981)

One hundreds seventy-one homosexual men, 96 of whom had symptoms suggestive of proctitis and 75 of whom had no such symptoms, were consecutively enrolled in a study of the prevalence, clinical spectrum, and histopathology of Chlamydia trachomatis rectal infections. C. trachomatis was isolated from the rectums of 14 men. Three of the isolates, which had lymphogranuloma venereum (LGV) immunotypes, were recovered from three men with symptoms and signs of severe proctitis, two of whom had granulomatous inflammation that was observed at rectal biopsy and was initially suggestive of Crohn's disease. Eleven isolates, which had non-LGV immunotypes, were obtained from eight symptomatic and three asymptomatic men, all of whom had fecal leukocytes and mild abnormalities of the mucosa present at sigmoidoscopy, usually with mild nongranulomatous inflammatory changes that were seen on rectal biopsy. These observations suggest that the presence of LGV immunotypes of C. trachomatis in the rectum is associated with severe acute proctitis that mimics Crohn's disease of the rectum, whereas the non-LGV immunotypes are associated with a mild proctitis with or without symptoms.
Automatic Analysis Of Petrographic Thin Section Images Of Sandstone (2018)

Summary Petrographic data remains one of fundamental information sources for characterization of hydrocarbon reservoirs. Thin section analysis of sandstone aims to describe depositional textures, major grain types and granulometric distribution, sedimentary structures, grain sorting, mineral composition, structural features, pore types, porosity, etc. These features are exploited to interpret the sedimentary environments, to predict the distribution of sedimentary bodies and their geometry which determines a recovery factor and other key reservoir exploitation characteristics. To conduct these studies one is to segment thin section images first – to partition them into grains, fractures, cleavages, pores, cement. The segmentation process is time-consuming as it is carried out manually or with specialized software that requires a proper recipe preparation for each image. The segmentation accuracy directly shapes the quality of further petrographic analysis. The goal of work is to develop a fully automatic algorithm for segmentation of thin section images for sandstone and further analysis of partitioned objects. The developed algorithm combines both image processing (IP) and deep learning (DL) approaches. IP methods exploit color intensity and local textural information to segment key structural elements in thin section image: voids (pores and fractures). The combination of DL and IP methods exploit primary information from images to solve semantic and instance segmentation problems for grains and to classify grains, cement and pores. Implementing of DL approaches demands a comprehensive training sample, full enough to have a reasonable segmentation accuracy. Thereby, the dataset of labeled images has been prepared manually. The developed algorithm has been efficiently applied for thin section analysis of sandstone. It has showed not only high agreement with manually processed thin sections and tremendous working time optimization, but more consistent results of segmentation as well. The algorithm plays a role of auxiliary tool that simplifies significantly the petrographic analysis of sandstone: most routine processes are automated; each thin section specimen can be processed statistically in a straightforward manner.
Traditional Medicinal Plants of Thailand. IV. 3-(2',3'-Diacetoxy-2'-Methyl Butyryl)-Cuauhtemone from Pluchea indica (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTraditional Medicinal Plants of Thailand. IV. 3-(2',3'-Diacetoxy-2'-Methyl Butyryl)-Cuauhtemone from Pluchea indicaSibabrata Mukhopadhyay, Geoffrey A. Cordell, Nijsiri Ruangrungsi, Supreeya Rodkird, Payom Tantivatana, and P. J. HylandsCite this: J. Nat. Prod. 1983, 46, 5, 671–674Publication Date (Print):September 1, 1983Publication History Published online1 July 2004Published inissue 1 September 1983https://pubs.acs.org/doi/10.1021/np50029a014https://doi.org/10.1021/np50029a014research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Immunological results of a phase II randomized trial of multipeptide vaccines for melanoma (2004)

7503 Background: To evaluate the immunogenicity of 12 peptides from cancer-testis and melanocyte differentiation proteins, and to assess the feasibility of complex peptide vaccines, a randomized phase II trial was performed in 51 patients with resected high-risk melanoma. Methods: Arm 1 received 4 peptides and arm 2 received 12 peptides. Each vaccine was an emulsion of 4 or 12 peptides (100ug each), a tetanus helper peptide (190ug), Montanide ISA-51 adjuvant (1 ml), and GM-CSF (110 ug). T-cell responses were evaluated in peripheral blood lymphocytes and in a sentinel immunized node by IFNγ ELIspot assay after one in vitro sensitization. Results: All patients have completed treatment; immunologic assessment is complete on 31 patients. Preliminary data from these 31 patients reveal immune responses in 11/14 patients (79%) on arm 1 and 17/17 patients (100%) on arm 2. Responses to 9 of the peptides are shown (Table). Patients on arm 2 responded to an average of 2.8 different peptides, those on arm 1 responded to an average of only 0.9 peptides. By comparing T cell responses to three index peptides in both peptide mixtures, it will be possible to assess whether co-administration of 4 peptides binding the same MHC molecule interferes with immunogenicity of the index peptides. Current results indicate that the median of the best immune responses for index peptides (fold-increase over background) was 9.7 in arm 1 and 11.1 in arm 2. The mean number of responses to index peptides per patient was 0.7 for Group 1, and 1.1 for Group 2. Conclusions: These findings support that (1) the most immunogenic peptides in this study were from tyrosinase, gp100, MAGE-A1, and MAGE-A10; (2) multiple peptides can be administered in combined aqueous mixture with safety and immunogenicity, and (3) immunogenicity is maintained despite peptide competition for binding to MHC. Further investigation of multiple-peptide vaccine mixtures is warranted. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration This was funded primarily by the NCI (R01 CA57653), but funding was provided by Immunex for purchase of GMCSF used in the vaccines
GRfid: A Device-Free RFID-Based Gesture Recognition System (2016)

Gesture recognition has emerged recently as a promising application in our daily lives. Owing to low cost, prevalent availability, and structural simplicity, RFID shall become a popular technology for gesture recognition. However, the performance of existing RFID-based gesture recognition systems is constrained by unfavorable intrusiveness to users, requiring users to attach tags on their bodies. To overcome this, we propose GRfid, a novel device-free gesture recognition system based on phase information output by COTS RFID devices. Our work stems from the key insight that the RFID phase information is capable of capturing the spatial features of various gestures with low-cost commodity hardware. In GRfid, after data are collected by hardware, we process the data by a sequence of functional blocks, namely data preprocessing, gesture detection, profiles training, and gesture recognition, all of which are well-designed to achieve high performance in gesture recognition. We have implemented GRfid with a commercial RFID reader and multiple tags, and conducted extensive experiments in different scenarios to evaluate its performance. The results demonstrate that GRfid can achieve an average recognition accuracy of 96.5 and 92.8 percent in the identical-position and diverse-positions scenario, respectively. Moreover, experiment results show that GRfid is robust against environmental interference and tag orientations.
Tantalum carbyne complex (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTantalum carbyne complexLloyd J. Guggenberger and Richard R. SchrockCite this: J. Am. Chem. Soc. 1975, 97, 10, 2935Publication Date (Print):May 1, 1975Publication History Published online1 May 2002Published inissue 1 May 1975https://pubs.acs.org/doi/10.1021/ja00843a072https://doi.org/10.1021/ja00843a072research-articleACS PublicationsRequest reuse permissionsArticle Views932Altmetric-Citations84LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Plastics in the Marine Environment (1974)

The pollution of the marine environment by plastics such as polyethylene, polyvinyl chloride, polystyrene, and polyurethane, is discussed. As plastic materials are relatively resistant to oxidative ageing and are generally not degraded by microorganisms, they will accumulate in coastal and oceanic waters. The origin of plastic pollutants, their distribution in the marine environment, and their persistence and ultimate fate, are largely unknown. The technology is available to manufacture plastic materials with a programmed service life which, if widely adopted, would reduce the accumulation of plastics in the sea. But their random distribution should be discouraged on behalf of the marine environment.