gebhart/patrepeval huggingface dataset:
ChemInform Abstract: IMIDAZOLE ALKALOIDS PART 2, SYNTHESIS AND REVISED STRUCTURE OF ISOLONGISTROBINE (1973)

Abstract Anhand UV‐spektroskopischer Untersuchungen und in Übereinstimmung mit der korrigierten Struktur für Dehydroisolongistrobin wird für Isolongistrobin die Struktur (I) postuliert.
Adaptive digital access protocol: a MAC protocol for multiservice broadband access networks (1996)

The authors describe a protocol that can adapt to the changing demands of a mix of synchronous transfer mode (STM) and asynchronous transfer mode (ATM) applications and efficiently allocate bandwidth to a variety of bursty traffic sources. In the case of a hybrid fiber-coaxial (HFC) network, the protocol resides in customer premises equipment (CPE) and a common head-end/central-office (HE/CO) controller. A medium-access control (MAC) processor provides for dividing the time domain for a given digital bitstream into successive frames, each with multiple STM and ATM time slots. Within the STM region of a frame, variable-length time slots are allocated to calls (e.g., telephony, video telephony) requiring different amounts of bandwidth. In the upstream channels, a contention access signaling time slot is also provided in the STM region for call control and setup requests. Within the ATM region, fixed-length time slots accommodate one individual ATM cell. These ATM time slots may be reserved for a user for either the duration of a call or a burst of successive ATM cells, or shared via a contention process. At least one contention time slot is available for signaling messages related to ATM call control and setup requests. The MAC-layer protocol, its relation to circuit- and ATM-amenable applications, and its performance with respect to throughput, latency, and bandwidth efficiency for several service scenarios are examined.
2-Stannyloxypyrimidines in Regioselective Alkylation Reactions. (1987)

Alkylation en 1 des composes du titre (prepares a partir d'hexabutyl distannoxane et d'halogeno ou phenylthio-5 1H-pyrimidones-2); obtention d'allyl-1-, benzyloxymethyl-1-, phenoxymethyl-1- et arylthiomethyl-1 1H-pyrimidones-2
Faster Decomposition Under Increased Atmospheric CO 2 Limits Soil Carbon Storage (2014)

Soils contain the largest pool of terrestrial organic carbon (C) and are a major source of atmospheric carbon dioxide (CO2). Thus, they may play a key role in modulating climate change. Rising atmospheric CO2 is expected to stimulate plant growth and soil C input but may also alter microbial decomposition. The combined effect of these responses on long-term C storage is unclear. Combining meta-analysis with data assimilation, we show that atmospheric CO2 enrichment stimulates both the input (+19.8%) and the turnover of C in soil (+16.5%). The increase in soil C turnover with rising CO2 leads to lower equilibrium soil C stocks than expected from the rise in soil C input alone, indicating that it is a general mechanism limiting C accumulation in soil.
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2 (2004)

Binding of Sonic Hedgehog (Shh) to Patched (Ptc) relieves the latter's tonic inhibition of Smoothened (Smo), a receptor that spans the cell membrane seven times. This initiates signaling which, by unknown mechanisms, regulates vertebrate developmental processes. We find that two molecules interact with mammalian Smo in an activation-dependent manner: G protein-coupled receptor kinase 2 (GRK2) leads to phosphorylation of Smo, and beta-arrestin 2 fused to green fluorescent protein interacts with Smo. These two processes promote endocytosis of Smo in clathrin-coated pits. Ptc inhibits association of beta-arrestin 2 with Smo, and this inhibition is relieved in cells treated with Shh. A Smo agonist stimulated and a Smo antagonist (cyclopamine) inhibited both phosphorylation of Smo by GRK2 and interaction of beta-arrestin 2 with Smo. beta-Arrestin 2 and GRK2 are thus potential mediators of signaling by activated Smo.
Towards virtual reality stimulation in force platform posturography. (2001)

We developed a stimulation technique on the basis of virtual reality methods for balance investigation performed in balance laboratories of otorhinolaryngological clinics and institutes of occupational health. Such a stimulation technique is greatly progressive in the sense that by creating virtual moving views and "virtual worlds" inside which the subject is located it is possible to make effective stimuli that would be very difficult or even impossible to set in any real environment. We tested our system on healthy subjects and found out that this kind of virtual reality stimulation system is very useful for balance analysis.
Optimizing Electrodynamic Tether System Performance (2009)

A time-averaged electrodynamic tether (EDT) system simulation tool has been developed and used to conduct studies of tether performance under varying conditions. The studies included evaluating passive end-body electron collection and active ion emission approaches, a comparison of active electron emission technologies (hollow-cathode, electron field emission, hot cathode), adjustment of bare conductor versus insulated tether lengths, boosting and de-boosting conditions, and other various system element configurations. The study results indicate that in many cases bare tether anodes provide optimal electron collection. In addition, it was shown that while hollow cathodes may be the best active electron emission technique, field emitter arrays result in less than 1% difference in average system thrusting and use no consumables. This is based on the assumption that multi-amp field emitter arrays can be ultimately fabricated and qualified for space. Three case-studies were performed in order to better understand the trades for performance optimization. The cases were: (1) orbit maintenance of the International Space Station; (2) the use of an EDT system for reboost and deorbit of NASA’s GLAST spacecraft; and, (3) operation of the Momentum Exchange Electrodynamic Reboost (MXER) system. From evaluation of these cases, a recommended design “algorithm” is proposed. Case (1) is presented in this paper in its entirety, and cases (2) and (3) are briefly described.
Improving first order differential power attacks through digital signal processing (2010)

Side-channel attacks pose a critical threat to the deployment of secure embedded systems. Differential-power analysis is a technique relying on measuring the power consumption of device while it computes a cryptographic primitive, and extracting the secret information from it exploiting the knowledge of the operations involving the key. There is no open literature describing how to properly employ Digital Signal Processing (DSP) techniques in order to improve the effectiveness of the attacks. This paper presents a pre-processing technique based on DSP, reducing the number of traces needed to perform an attack by an order of magnitude with respect to the results obtained with raw datasets, and puts it into practical use attacking a commercial 32-bit software implementation of AES running on a Cortex-M3 CPU. The main contribution of this paper is proposing a leakage model for software implemented cryptographic primitives and an effective framework to extract it.
Descemet's stripping automated endothelial keratoplasty with anterior chamber intraocular lenses: complications and 3-year outcomes (2014)

We found that although eyes with BK and ACIOL that underwent DSAEK while retaining the ACIOL suffered EC loss which was not significantly greater at 1 year, EC loss and graft survival were significantly poorer compared to DSAEK controls at 3 years postoperatively.
<title>Precision conformal optics technology program</title> (2001)

Conformal optics are defined as optics that deviate from conventional form to best satisfy the contour and shape needs of system platforms. Precision Conformal Optics Technology (PCOT), a comprehensive 48 month program funded by the Defense Advanced Research Program Agency (DARPA) and the U. S. Army Missile Research, Development, and Engineering Center (MRDEC), assessed the potential benefits achieved by use of conformal optics on a variety of U.S. weapon systems. Also addressed were all barriers impeding conformal optics use. The PCOT program was executed by a consortium of organizations ranging from major U.S. defense prime contractors, to small businesses, and academia. The diversity of organizations encouraged synergy across a broad array of skills and perspectives. Smooth team interaction was made possible by the 845 contractual structure of the program. Benefits identified by the PCOT consortium included major reductions in aerodynamic drag (by as much as 50%), reduced time-to-targets (by as much as 60%), and reduced weapon signatures. Impediments addressed included inadequacies in optical design tools, optical manufacturing methods and equipment, optical testing, and system integration. The PCOT program was successfully completed with a demonstration of a highly contoured missile dome, which reduced overall missile drag by 25%, and led to a predicted twofold increase in missile range.
[Changes in thrombocyte aggregation in primary hypothyroidism]. (1998)

The authors examined the thrombocyte aggregation in 10 controls and 17 patients with the diagnosis of primary hypothyroidism before and after 2 months substitution treatment with levothyroxine. They recorded a significantly reduced intensity of the aggregation response in untreated patients as compared with controls after adrenaline (p < 0.01), ADP (p < 0.01) but not after ristocetin. Impaired thrombocyte aggregation was observed in 11 of 17 patients, i.e. in 65%. After treatment the thrombocytopathy improved in 7 of 11 patients (63%), in four it persisted. Except one female patient the thrombocytopathy improved in all patients with manifest hypothyroidism. In patients with the latent form of hypothyroidism probably an independent coincidence of elevated TSH levels and impaired thrombocyte function was involved. The authors did not detect any cases of acquired von Willebrand's disease. In the conclusion the authors mention that impaired thrombocyte aggregation is a frequent phenomenon after thyroxine treatment. It may be of clinical significance when combined with other changes of haemostasis or in conjunction with the use of some drugs.
Effects of temperature on germination of sporangia, infection and protein secretion by Phytophthora kernoviae (2017)

Phytophthora kernoviae is a pathogen on a wide range of plants, but little is known of optimal infection conditions. Rhododendron ponticum leaves were inoculated with six different isolates of P. kernoviae sporangia and incubated at different temperatures from 10 to 28 °C. After 1 week, lesion development and pathogen recovery were only observed from all isolates at 15 and 20 °C and a few isolates at 10 °C. In an experiment with temperatures ranging from 20 to 25 °C, lesion development and pathogen recovery on R. ponticum , Magnolia stellata and Viburnum tinus occurred consistently at 20 and 21 °C, was limited at 22 °C, and did not occur at 23 °C and above. There was no difference in sporangia and zoospore germination at 20–25 °C. In a temperature fluctuation experiment, the necrotic area of inoculated R. ponticum leaves increased with longer incubation at 20 °C and decreased with longer incubation at 24 °C. Crude extracts of secreted proteins from P. kernoviae cultures grown at 20 and 24 °C were compared to determine any effects of temperature on pathogenicity. When spot tested on R. ponticum leaves, crude protein suspensions from cultures grown at 20 °C induced necrosis, while proteins from cultures grown at 24 °C did not. Proteomic analysis confirmed that a 10 kDa protein secreted at both 20 and 24 °C shared sequence homology to the conserved domains of known elicitins of other Phytophthora spp. The protein secreted at 20 °C that was responsible for necrosis has not been identified.
Achievement in active agent structures as a power tools in tumor angiogenesis imaging (2021)

According to World Health Organization (WHO) cancer is the second most important cause of death globally. Because angiogenesis is considered as an essential process of growth, proliferation and tumor progression, within this review we decided to shade light on recent development of chemical compounds which play a significant role in its imaging and monitoring. Indeed, the review gives insight about the current achievements of active agents structures involved in imaging techniques such as: positron emission computed tomography (PET), magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT), as well as combination PET/MRI and PET/CT. The review aims to provide the journal audience with a comprehensive and in-deep understanding of chemistry policy in tumor angiogenesis imaging.
A genetic algorithm for the post take-off manoeuvre optimization (1997)

This work introduces and compares dif- ferent optimization methods to find the best longitudinal manoeuvre required to an aircraft to reach, after take- off, in the minimum time a given altitude at a given speed. A longitudinal flight simulator based on non- linear equations, integrated numerically with a Runge- kutta method, has been built. The optimization algorithm used in this case is based on G.A. theory (Genetic Algorithms), in comparison with a simple random-search algorithm and a random- search and gradient-descending algorithm. Good performances have been observed as long as the cost function of the G.A. is well adapted to the problem. A number of situations have been analized and compared with the results and performances given by simpler algo- rithms based on random search. Common optimization algorithms based on gradient descending cannot be used in this case, since there are too many sub-optimal solu- tions. Results are presented as comparisons between the time histories related to the elevator angle. The results obtained with the GA and random search calculation programs are practically identical; but in the second case the calculation time to obtain the optimizated manoeu- vre is much lower.
Absorption of carbon dioxide into aqueous potassium carbonate promoted by boric acid (2009)

The absorption of carbon dioxide with alkanolamine or potassium carbonate solvents has gained widespre ad acceptance for the removal of CO2 from natural gas and H 2. However, alkanolamine solutions are prone to oxidative degradation at high temperature. The main advantages of potassium carbonate solution for CO2 removal are the high chemical solubility of CO2 in the carbonate/ bicarbonate system, low solvent costs and the low energy requirement for solvent regeneration. The major challenge concerning absorption of CO2 into aqueous solutions of potassium carbonate is a relatively slow rate of reaction in the liquid phase causing low mass transfer rates. It is often advantageous to add a promoter to increase the absorption rate. While piperazine is often used for this purpose, there are some environmental health concerns with this approach. In this work we consider boric acid as an alternative promoter. Absorption of CO2 in a wetted -wall column by aqueous potassium carbonate solution with and without various concentrations of boric acid as promoter was measured under conditions in which the reaction of CO2 was of pseudo-first order. The equilibrium partial pressure and the rate of absorption of CO2 were measured in 30.0 wt% potassium carbonate and 1.0 to 5.0 wt% of boric acid at 50 to 80 ∘C. The overall pseudo -first-order reaction rate constants were determined fro m the kinetic measurements. The addition of small amounts of boric acid to potassium carbonate resulted in a significant enhancement of CO2 absorption rates.
Antifungal Activities of 8-O-4′-Neolignans fromMyristica Fragrans (1996)

Abstract Antifungal activity of (±)-erythro-Δ8−4,7-dihydroxy-3,3′,5′-trimethoxy-8-O-4′-neoneolignan derivatives against several plant pathogenic fungi has been investigated. Key Words: Myristica fragrans MyristicaceaePythium debaryanumPhytophthora infestans. Pyricularia oryzaeBotrytis cinereaRhizoctonia solani8- O-4′-neolignan
MIR/NIR/FIR Characterization of Poly‐AMMO and Poly‐BAMO and their Precursors as Energetic Binders to be Used in Solid Propellants (2006)

Abstract To establish the relation between structure and properties of composite solid propellants it is important to know the structure of the elastomeric binder that has been used in the system. Therefore this study is focused on the characterization of polymers containing energetic groups that has been synthesized at ICT. The characterization uses the wide spectral band of infrared, NIR/MIR/FIR. This gives an identification of the analytical bands and allows quantitative and kinetic studies of these compounds.
SEVENTH REPORT OF THE HUMAN KIDNEY TRANSPLANT REGISTRY Sponsored by the Advisory Committee of the Human Kidney Transplant Registry (1969)

The collected experience of 2321 kidney transplantations, of which 30% were performed in 1907 and 1908, has permitted calculation of transplant survivals as follows. Kidneys from consanguineous related living donors have a 1-year survival of 87% (SE, 3) and a 2-year survival of 77%. (SE, 4); kidneys from cadaver donors have a 1-year survival of 42% (SE, 5) and a 2-year survival of 40% (SE, 3). Improvement in transplant survival from all categories of donors is noted with the exception of cadaver kidneys, where no improvement has occurred in the past year.
Theory and Design of Class-J Power Amplifiers With Dynamic Load Modulation (2012)

A theory for class-J microwave amplifier operation as a function of drive level and fundamental load impedance is derived. Calculations show that, under appropriate operating conditions, it is sufficient to modulate the transistor load reactance to enable high-efficiency operation (>;70%) over a large output power dynamic range (>;10 dB) with high transistor power utilization. Such dynamic load modulation (DLM) networks are an ideal application of continuously tunable varactor technologies. Multiharmonic load-pull measurements are performed on a GaN HEMT and experimentally verify the theory of operation. A demonstrator amplifier using an SiC varactor technology is then designed and characterized by static measurements. The amplifier has a peak power of 38 dBm at 2.08 GHz and maintains efficiencies above 45% over 8 dB of power dynamic range. An analysis of the load network losses is performed to show the potential of the class-J DLM transmitter concept.
Decision letter: HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain (2021)

Quantitative time-resolved crosslinking mass spectrometry is developed to monitor protein interactions and dynamics inside molecular condensates and used to identify misfolding of the RNA-binding domain of FUS as a key driver of condensate-aging.
Asymmetric real-time PCR and multiplex melting curve analysis with TaqMan probes for detecting PIK3CA mutations (2015)

The data in this article are related to the research article entitled "Optimization of melting analysis with TaqMan probes for detection of KRAS, NRAS, and BRAF mutations" Botezatu et al. [1]. Somatic mutations in the PIK3CA gene ("hot spots" in exons 9 and 20) are found in many human cancers, and their presence can determine prognosis and a treatment strategy. An effective method of mutation scanning PIK3CA in clinical laboratories is DNA Melting Analysis (DMA) (Vorkas et al., 2010; Simi et al., 2008) [2], [3]. It was demonstrated recently that the TaqMan probes which have been long used in Real Time PCR may also be utilized in DMA (Huang et al., 2011) [4]. After optimization of this method Botezatu et al. [1], it was used for multiplex scanning PIK3CA hotspot mutations in formalin-fixed paraffin-embedded (FFPE) samples from patients with colorectal and lung cancer.
Diffuse Interface in a Critical Fluid Mixture (1969)

The interface between the two fluids in equilibrium at temperature T below the critical (consolute) temperature Tc of a binary mixture in a gravitational field has been observed to expand into a transition layer that thickens, while the coexisting phases become more similar and the interfacial energy vanishes as T→Tc. The effective thickness L of the transition layer has been deduced from reflectivity measurements as a function of light wavelength λ and temperature. The shape of the interface concentration distribution function has been found from the λ dependence of the reflectivity to be close to an error functon and to a function recently proposed by Fisk and Widom and distinguishable from the classical hyperbolic tangent distribution. In the range 0.02 &amp;lt; Δ T &amp;lt; 3.0°C, L∝(ΔT)−ν where ν = 0.67 ± 0.02 and ξ the appropriately defined thickness L′ = 2(Δ T / Tc)−0.67 is comparable with the correlation length of the bulk fluids for corresponding ΔT. The critical index ν, together with the critical index β for the coexistence curve, and μ for the surface tension, can be combined to test various theoretical relations amongst the critical exponents and theories of the critical interface.
Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin (2014)

We demonstrate that the effects of lonidamine (LND, 100 mg/kg, i.p.) are similar for a number of xenograft models of human cancer including DB-1 melanoma and HCC1806 breast, BT-474 breast, LNCaP prostate and A2870 ovarian carcinomas. Following treatment with LND, each of these tumors exhibits a rapid decrease in intracellular pH, a small decrease in extracellular pH, a concomitant monotonic decrease in nucleoside triphosphate and an increase in inorganic phosphate over a 2-3 h period. We have previously demonstrated that selective intracellular tumor acidification potentiates response of this melanoma model to melphalan (7.5 mg/kg, i.v.), producing an estimated 89% cell kill based on tumor growth delay analysis. We now show that, in both DB-1 melanoma and HCC1806 breast carcinoma, LND potentiates response to doxorubicin, producing 95% cell kill in DB-1 melanoma at 7.5 mg/kg, i.v. doxorubicin and 98% cell kill at 10.0 mg/kg doxorubicin, and producing a 95% cell kill in HCC1806 breast carcinoma at 12.0 mg/kg doxorubicin. Potentiation of doxorubicin may result from cation trapping of the weakly basic anthracycline. Recent experience with the clinical treatment of melanoma and other forms of human cancer suggests that these diseases will probably not be cured by a single therapeutic procedure other than surgery. A multimodality therapeutic approach will be required. As a potent modulator of tumor response to N-mustards and anthracyclines as well as tumor thermo- and radiosensitivity, LND promises to play an important clinical role in the management and possible complete local control of a number of prevalent forms of human cancer.