gebhart/patrepeval huggingface dataset:
Discrete direct adaptive ELM controller for seismically excited non-linear base-isolated buildings (2013)

Structures with fixed-base will produce high accelerations and inter-storey drifts and move laterally during earthquake. The presence of base isolation devices between ground and the structure, reduces the structural vibrations. To maintain the seismic response of structures within safety, service and comfort limits, the combination of base isolators and feedback controllers have been proposed in recent years. This paper proposes a discrete direct adaptive extreme learning machine (ELM) controller for the active control of non linear base isolated building with hysteretic isolation system. The controller is constructed based on a single hidden layer feed forward network and the parameters of the network are adapted using extreme learning machine (ELM) algorithm. In this work, different from the original ELM algorithm the output weights of the network are updated using Lyapunov stability approach, to guarantee the stability of the structure. The performance of the proposed controller is verified on a non-linear three dimensional benchmark base-isolated structure by exciting the structure with three earthquake samples. The result shows that the proposed controller is effective in reducing the seismic responses of the isolation members as well as the superstructure.
AVIS de l’Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail relatif à « l’analyse de risques phytosanitaires portant sur Rhagoletis completa » (2014)

Rhagoletis completa est un insecte (Diptera : Tephritidae) nuisible listé à l’annexe I, partie A, chapitre I de la directive 2000/29/CE. À ce titre, cet organisme nuisible est également listé en annexe B de l’arrêté du 31 juillet 2000, ce qui en fait un organisme de lutte obligatoire sous certaines conditions sur tout le territoire français. En France métropolitaine, cet organisme nuisible est très largement répandu dans le bassin de production du grand sud-est où la stratégie de lutte mise en place visait à limiter sa pression. Il est également présent dans le bassin de production du grand sud-ouest (Aquitaine et Midi- Pyrénées), bien que le coeur de ce bassin de production de noix semble encore préservé. La stratégie mise en place dans cette région vise encore à limiter son extension et à protéger les zones encore exemptes. Au vu de la dispersion de R. completa dans le grand sud-est, l’Anses est saisie pour la réalisation d’une analyse de risques phytosanitaires (ARP) portant sur R. completa et ce, sur l’ensemble du territoire de l’Union Européenne. Cette ARP pourra servir de base aux discussions communautaires permettant la révision du statut de cet organisme au sein de la directive 2000/29/CE ainsi que la définition de mesures de gestion appropriées le cas échéant dans le cadre du dispositif passeport phytosanitaire européen (PPE).
Infra-slow modulation of fast beta/gamma oscillations in the mouse visual system (2020)

ABSTRACT Infra-slow (&lt;0.02 Hz) and fast beta/gamma (20 – 100 Hz) oscillations in neurophysiological activity have been widely found in the subcortical visual system. While it is well established that fast beta/gamma oscillations are involved in visual processing, the role (if any) of infra-slow oscillations is currently unknown. One possibility is that infra-slow oscillations exert influence by modulating the amplitude of fast oscillations, yet the extent to which these different oscillations arise independently and interact remains unknown. We addressed these questions by recording in vivo spontaneous activity from subcortical visual system of visually intact mice, and animals whose retinal network was disrupted by advanced rod/cone degeneration ( rd/rd cl ) or melanopsin loss (Opn4 -/- We found many neurons expressing only one type of oscillation, and indeed fast oscillations were absent in rd/rd cl. Conversely, neurons co-expressing the two oscillations were also common, and were encountered more often than expected by chance in visually intact but not Opn4 -/- mice. Finally, where they co-occurred we found that beta/gamma amplitude was modulated by the infra-slow rhythm. Our data thus reveal that: 1.) infra-slow and beta-gamma oscillations are separable phenomena; and 2.) that they actively co-occur in a subset of neurones in which the phase of infra-slow oscillations define beta-gamma oscillation amplitude. These findings suggest that infra-slow oscillations could influence vision by modulating beta-gamma oscillations, and raise the possibility that disruptions in these oscillatory behaviours contribute to vision dysfunction in retinal dystrophy. KEY POINTS SUMMARY Neurophysiological activity in the subcortical visual system fluctuates in both infra-slow and fast oscillatory ranges, however the level of co-occurrence and potential functional interaction of these rhythms is unknown. Analyzing dark-adapted spontaneous activity in the mouse subcortical visual system, we find that these two types of oscillation interact uniquely through a population of neurons expressing both rhythms. Genetic ablation of rod/cone signaling potentiates infra-slow and abolishes fast beta/gamma oscillations while genetic ablation of melanopsin substantially diminishes the interaction between these two rhythms. Our results indicate that in an intact visual system the phase of infra-slow modulates fast beta/gamma oscillations. Thus one possible impact of infra-slow oscillations in vision is to guide visual processing by interacting with fast narrowband oscillations.
Optoacoustic detector arrays for medical imaging applications. (2003)

Better image resolution would expand the frontiers of ultrasound for both clinical diagnostics and medical research, particularly with spatial resolutions at the subcellular level (&le;10mum). The limit on spatial resolution for a particular ultrasound imaging system is imposed by the system electronics together with the physical and electrical characteristics of the array elements. In general, the system electronics is not the technologically limiting factor, and the array element characteristics depend on the method used to generate and detect ultrasound: piezoelectric, capacitive, or optical. Optoacoustic (OA) detectors have been much-touted for their potential as high resolution, high bandwidth transducers with the possibility of miniaturization, selectable operating frequency, and simple fabrication. For medical applications, the reduced sensitivity of existing OA array detectors with respect to piezoelectric detectors is a considerable deterrent. We have studied stabilized resonant structures for high sensitivity optical detection of ultrasound in medical imaging applications. The theoretical performance of Fabry-Perot (FP) resonant optical elements is well documented, and we establish the parameters required of an ideal FP-based OA detector for sensitivity equivalence to ideal piezoelectric array elements. High-finesse structures are required to achieve the desired sensitivities. Not only are there challenges associated with fabricating FP resonators of high finesse, but the goal of using such a device as an imaging array with an acceptable dynamic range is shown to lead to the requirement of mirror surface imperfections and thickness uniformity constrained to better than that possible with state-of-the-art fabrication methods. We have studied active stabilization of the FP element as a means of circumventing this constraint. The methods available to effect stabilization include control of (1) laser wavelength, (2) physical path length, and (3) index of refraction. With the promise of sufficient tuning range, high tuning sensitivity, excellent bandwidth, high stability and ease of implementation, index of refraction control is the most attractive approach. Simulations of thermo-optic and electro-optic stabilization for resonant optoacoustic detectors indicate excellent potential for use as array detectors. We have fabricated prototypes of index of refraction stabilized resonant optoacoustic detectors and demonstrate their potential for use as sensitive optoacoustic detectors.
3D micro-optical lens scanner made by multi-wafer bonding technology (2013)

We present the preliminary design, construction and technology of a microoptical, millimeter-size 3-D microlens scanner, which is a key-component for a number of optical on-chip microscopes with emphasis on the architecture of confocal microscope. The construction of the device relies on the vertical integration of micromachined building blocks: top glass lid, silicon electrostatic comb-drive X-Y and Z microactuators with integrated scanning microlenses, ceramic LTCC spacer, and bottom lid with focusing microlens. All components are connected on the wafer level only by sequential anodic bonding. The technology of through wafer vias is applied to create electrical connections through a stack of wafers. More generally, the presented bonding/connection technologies are also of a great importance for the development of various silicon-based devices based on vertical integration scheme. This approach offers a space-effective integration of complex MOEMS devices and an effective integration of various heterogeneous technologies.
Screw theory-based stiffness analysis for a fluidic-driven soft robotic manipulator (2021)

Soft robotic manipulators have been created and investigated for a number of applications due to their advantages over rigid robots. In minimally invasive surgery, for instance, soft robots have successfully demonstrated a number of benefits due to the compliant and flexible nature of the material they are made of. However, these type of robots struggle with performing tasks that require on-demand stiffness i.e. exerting higher forces to the surrounding environment. A number of semi-active and active mechanisms have been investigated to change and control the stiffness of soft robotic manipulators. Embedding these mechanisms in soft manipulators for spacerestricted applications can be challenging though.To better understand the inherent passive stiffness properties of soft manipulators, we propose a screw theory-based stiffness analysis for fluidic-driven continuum soft robotic manipulators. First, we derive the forward kinematics based on a parameter-based piece-wise constant curvature model. It is worth noting, our stiffness analysis can be conducted based on any freespace forward kinematic model. Then our stiffness analysis and mapping methodology is conducted based on screw theory. Initial results of our approach demonstrate the feasibility comparing computational and experimental data.
Necuparanib combined with nab-paclitaxel + gemcitabine in patients with metastatic pancreatic cancer: Phase 2 results. (2017)

370 Background: The Phase 1 portion of a Phase 1/2 trial of Necuparanib (“Necu”) combined with nab-paclitaxel (nabP) + gemcitabine (gem) in patients with metastatic pancreatic cancer (ClinicalTrials.gov Identifier NCT01621243) showed acceptable safety and tolerability and encouraging signals of activity and established a dose for the randomized, placebo (PBO)-controlled Phase 2 portion. Methods: In Phase 2, patients received daily s.c. injections of either 5 mg/kg Necu daily or PBO, combined with i.v. 125 mg/m 2 nabP and 1000 mg/m 2 gem (Days 1, 8, 15 of each 28-day cycle). The primary endpoint was overall survival (OS); other endpoints included progression-free survival (PFS), response rates, safety, and CA19.9 levels. An interim futility analysis was conducted in July 2016 once 57 deaths (50% of the target number of 114 events required for trial completion) had occurred. Results: The analysis was conducted on data from 120 randomized patients (62 Necu, 58 PBO). The Z-score for futility was -0.42 (prespecified boundary of -0.148 was crossed as actual score was lower). Median OS was Necu = 10.71 and PBO = 9.99 months; hazard ratio (HR) = 1.12 (favoring PBO); OS curves were intertwined. PFS was Necu = 5.52 and PBO = 6.93 months; HR = 0.97. RECIST response rates were comparable between arms: complete response, Necu = 0%, PBO = 3%; partial response, Necu = 26%, PBO = 26%; stable disease, Necu = 31%, PBO = 34%; disease control rate, Necu = 56%, PBO = 64%. The most common Grade 3+ adverse events (AEs) were neutropenia (Necu = 33%, PBO = 33%), thrombocytopenia (Necu = 27%, PBO = 5%), and anemia (Necu = 22%, PBO = 11%). There were lower rate of serious AEs with Necu (48%) vs. PBO (60%). Modest increases in APTT, AST, and ALT were noted following Necu relative to PBO. 23% of Necu and 5% of PBO patients were IgG positive with an anti-heparin/PF4 antibody titer of ≥ 0.4 at any time. There were no treatment differences for decreases in CA19.9. Conclusions: No new safety signals were observed and the toxicity profile was considered manageable; however, Necu in combination with nabP and gem did not show a sufficient level of efficacy in metastatic pancreatic cancer to warrant continued enrollment. Clinical trial information: NCT01621243.
Quantum Hall effects in a Weyl semimetal: Possible application in pyrochlore iridates (2011)

There has been much interest in pyrochlore iridates A${}_{2}$Ir${}_{2}$O${}_{7}$ where both strong spin-orbital coupling and strong correlation are present. A recent local density approximation calculation [X. Wan, A. M. Turner, A. Vishwanath, and S. Y. Savrasov, Phys. Rev. B 83, 205101 (2011)] suggests that the system is likely in a three-dimensional topological semimetallic phase: a Weyl semimetal. Such a system has zero carrier density and arrives at the quantum limit even in a weak magnetic field. In this paper, we discuss two quantum effects of this system in a magnetic field: a pressure-induced anomalous Hall effect and a magnetic-field-induced charge density wave at the pinned wave vector connecting Weyl nodes with opposite chiralities. A general formula of the anomalous Hall coefficients in a Weyl semimetal is also given. Both proposed effects can be probed by experiments in the near future and can be used to detect the Weyl semimetal phase.
Identification of gel-separated tumor marker proteins by mass spectrometry (2000)

Two-dimensional gel electrophoresis with subsequent analysis by mass spectrometry was applied to study differences in protein expression between benign and malignant solid tumors from human beast, lung and ovary cells. Cells from freshly resected clinical material were lysed and the extracts were subjected to isoelectric focusing with immobilized pH gradients followed by second-dimensional separation on 10—13% sodium dodecyl sulfate (SDS)/polyacrylamide gels. Polypeptides were identified using matrix-assisted laser desorption/ionization and electrospray ionization mass spectrometry after in-gel protein digestion. Some of the upregulated polypeptides in malignant cells are of potential importance as markers of tumor proliferation. Twenty such proteins were identified, ten constituting novel identifications and ten sequence verifications of previously gel-matched proteins. The proteins identified span a wide range of functions, but several cases of protein truncation were found. Truncated forms of cytokeratins 6D and 8, and of cathepsin D were identified. Truncated froms of these overexpressed proteins support the presence of proteolytic processing steps in tumor material. The protein processing and the difference between protein and mRNA abundancies in tumors of different malignancy and origin suggest that studies at the protein level are important for an understanding of tumor phenotypes.
Atomistic Modeling of Quantum Dots at Experimentally Relevant Scales Using Charge Equilibration (2017)

Quantum dots (QDs) have been successfully employed within a vast array of fundamental and applied studies spanning all subdisciplines of chemistry. However, ab initio models of QD behavior are inherently limited by computational cost due to the large number of atoms within QDs of experimentally relevant size. This work builds upon the method of charge equilibration (qEQ) to account for system interactions unique to QDs (QD-qEQ) and demonstrates accuracy through calculated per-QD energies and dipole moments that agree generally with ab initio calculations and experimental observation, respectively. By forgoing electronic structure information, QD-qEQ exhibits a distinct advantage in its exceptionally low computational cost, which affords consideration of over 35,000 unique spherical wurtzite CdSe structures with radii ≤12.5 Å. A comparison of QD-qEQ calculations with experimental data relating to the phenomenon of CdSe magic size crystals (MSCs) affords statistical and structural insight into why MSCs are observed. Consideration of structures ≤12.5 Å reveals QD sizes corresponding with local minima in QD energy, correlating closely with experimentally observed MSCs. The physical origin of observed energy minima is assigned to QD structures with surfaces exhibiting large fractions of highly coordinated atoms, a physical trait postulated to yield fewer reaction sites for stepwise growth, resulting in MSC stability. The low computational cost along with the per-atom and per-structure electrostatic data afforded by QD-qEQ makes this method an enticing approach to address dynamic QD behavior and enables potential applications within a broad range of fields concomitant to those in which QD inclusion has already proven useful.
A critical appraisal of nonsurgical modalities for managing hypertrophic scars and keloids (2015)

The nature of hypertrophic scars and keloids can be unpredictable even to the most experienced physicians. Predicting the susceptibility and severity of these disorders is difficult. The availability of numerous treatment options which yield various results make deciding on a course of treatment difficult. Further complicating the selection of treatment options are the numerous industry-driven publications that seem biased and are supported by marketing strategies for related products. Physicians often end up using a treatment modality that is not particularly objective or supported by a high level of evidence. Reviewing literature on this topic can be daunting. This study attempts to clarify the complex fibroproliferative disorder of skin wound healing by briefly describing its pathophysiology, categorizing patients into distinct groups based on their clinical behavior, and analyzing relevant evidence for each treatment modality.
A re-evaluation of LINE-1 ORF2 expression in LNCaP prostate cancer cells (2019)

Overall, our findings indicate that chA1-L1 antibody recognizes both BCLAF1 and ORF2p but the majority of antigen recognized in LNCaP cells is BCLAF1.
An optimization approach to recognition of epileptogenic data using neural networks with simplified input layers. (2004)

This study introduces a simplified approach for the implementation of artificial neural networks (ANN) for the recognition of epileptic data in electroencephalograph (EEG) recordings. The training set construction is based on a trend-adaptive polygon which simplifies the search process as it reduces the size of the training set. This data reduction, at a sampling rate of 200 Hz, yielded a reduction ratio of 34% as a minimum to an 81% in the best case scenario. With a higher sampling rate of 500 Hz, a reduction ratio of 73% as a minimum to an impressive 92% in the best case scenario was achieved. The outcome is thus a computationally attractive classifier with a simpler design implementation and with higher prospects for accurate diagnosis. The algorithm was trained and tested with EEG data from four epileptic patients using the k-fold cross-validation technique.
Effect of laser irradiation on the spectra of polariton Raman scattering of light in a lithium niobate crystal (1983)

The dependence of the shape of the polariton Raman light scattering spectra of a lithium niobate crystal on the scattering by optical distortions produced by laser irradiations is investigated. (AIP)
Association Between a Cell-Seeded Collagen Matrix and Cellular Cardiomyoplasty for Myocardial Support and Regeneration (2007)

The objective of cellular cardiomyoplasty is to regenerate the myocardium using implantation of living cells. Because the extracellular myocardial matrix is deeply altered in ischemic cardiomyopathies, it could be important to create a procedure aiming at regenerating both myocardial cells and the extracellular matrix. We evaluated the potential of a collagen matrix seeded with cells and grafted onto infarcted ventricles. A myocardial infarction was created in 45 mice using coronary artery ligation. Animals were randomly assigned to 4 local myocardial treatment groups. Group I underwent sham treatment (injection of cell culture medium). Group II underwent injection of human umbilical cord blood mononuclear cells (HUCBCs). Group III underwent injection of HUCBCs and fixation onto the epicardium of a collagen matrix seeded with HUCBCs. Group IV underwent fixation of collagen matrix (without cells) onto the infarct. Echocardiography was performed on postoperative days 7 and 45, followed by histological studies. Echocardiography showed that the association between the cell-loaded matrix and the intrainfarct cell implants was the most efficient approach to limiting postischemic ventricular dilation and remodeling. Ejection fraction improved in both cell-treated groups. The collagen matrix alone did not improve left ventricular (LV) function and remodeling. Histology in Group III showed fragments of the collagen matrix thickening and protecting the infarct scars. Segments of the matrix were consistently aligned along the LV wall, and cells were assembled within the collagen fibers in large populations. Intramyocardial injection of HUCBCs preserves LV function following infarction. The use of a cell-seeded matrix combined with cell injections prevents ventricular wall thinning and limits postischemic remodeling. This tissue engineering approach seems to improve the efficiency of cellular cardiomyoplasty and could emerge as a new therapeutic tool for the prevention of adverse remodeling and progressive heart failure.
Adsorption of bile salts to particles allows penetration of intestinal mucus (2011)

Mucus forms a protective layer across a variety of epithelial surfaces, presenting a barrier to the uptake of particulates, including bacteria. In the gastrointestinal (GI) tract the barrier has to permit uptake of nutrients, whilst excluding potential hazards, such as bacteria. We have investigated the abilities of an exemplar food-derived particulate and a model bacterium to diffuse through porcine intestinal mucus as a model system. Transport was dramatically enhanced by adsorption of bile salts (BS), diffusion of 500-nm latex beads through mucus increased by three orders of magnitude over 2 min compared to the absence of BS. The diffusion coefficients, a probe of local mucus microrheology, showed a range of apparent viscosity from 1 mPas to at least 10 PaS. Similar effects of BS adsorption on diffusion were observed for model food emulsion droplets after simulated gastrointestinal digestion. In contrast, a non-motile bacterium, E. Coli, was found neither to diffuse through the mucus nor adhere to the mucus, regardless of the presence of BS. The negative charge imparted by BS adsorption significantly changed the electrostatic interactions with the mucus network, which is also primarily negatively charged. Thus, interfacial BS have a dominant role in determining transport of colloidal particles, including digested fat through the intestinal mucus but do not reduce the ability of the mucus to act as a barrier to bacteria. This information is important for the targeted delivery of bioactive molecules, including nutrients and pharmaceuticals and for understanding how GI health is maintained.