gebhart/patrepeval huggingface dataset:
Increased Depressive Ratings in Patients With Hepatitis C Receiving Interferon-α–Based Immunotherapy Are Related to Interferon-α–Induced Changes in the Serotonergic System (2002)

There is now evidence that repeated administration of interferon-alpha (IFN-alpha) to patients with chronic active hepatitis and cancers induces depressive symptoms. There is also evidence that induction of the cytokine network modulates the serotonergic system and that major depression is related to activation of the cytokine network and disturbances in the serotonergic metabolism. The aims of this study were to examine the effects of IFN-alpha-based immunotherapy on the development of depressive symptoms in relation to its effects on plasma tryptophan and kynurenine and serum serotonin (5-HT). Eighteen patients affected by chronic active hepatitis C were treated with IFN-alpha (3-6 million units subcutaneously three to six times a week for 6 months) and had measurements of the previous parameters before starting immunotherapy and 2, 4, 16, and 24 weeks later. Severity of depression and anxiety were measured with the Montgomery-Asberg Depression Rating Scale (MADRS) and the Hamilton Rating Scale for Anxiety (HAM-A) scale, respectively. Immunochemotherapy with IFN-alpha (1) significantly increased the MADRS and HAM-A scores and serum kynurenine concentrations and (2) significantly reduced plasma tryptophan and serum 5-HT concentrations. IFN-alpha-based immunotherapy significantly increased the kynurenine per tryptophan quotient, which estimates the activity of indoleamine 2,3-dioxygenase, the major tryptophan-catabolizing enzyme, which is induced by IFNs. There are significant relationships between the IFN-alpha-induced changes in the MADRS score and serum kynurenine (positive) and 5-HT (negative) concentrations. Immunotherapy with IFN-alpha significantly increases the severity of depressive symptoms. The latter is related to changes in the serotonergic system, such as depletion of serum 5-HT and induction of the catabolism of tryptophan to kynurenine. It is suggested that the IFN-alpha-induced changes in the serotonergic turnover could play a role in the development of IFN-alpha-induced depressive symptoms.
Source density apodisation in 2D all-optical ultrasound imaging (2017)

In this work, an all-optical ultrasound imaging system that is capable of synthesising arbitrary source aperture geometries is presented. This capability is achieved by delivering focussed excitation light onto a spatially extended generating surface, where ultrasound is generated photoacoustically. Using a scanning mirror, the position of the resulting acoustical source was continuously varied to scan an aperture. This system exhibited sufficient sensitivity to acquire 2D images of clinically relevant tissue in under a second, as demonstrated on a tissue-mimicking phantom. The flexibility in the source array geometry was demonstrated through the implementation of two source array geometries on the same system, which allowed for the direct comparison of the image quality. It was shown that applying source density apodisation to obtain an aperiodic source array resulted in an improvement of up to 5 dB in image contrast, as compared to using a conventional, periodic array exhibiting the same number of sources and spatial extents.
Automatic robot taping: Auto-path planning and manipulation (2015)

Many industrial applications, such as painting, plasma spraying, require people to work long hours to cover the uninvolved part with masking tapes. In this paper, we introduce an automatic robot taping system which can reconstruct the 3D model of the taping part, do path planning and complete the surface covering of the parts using masking tapes automatically. The system uses a Kinect as the 3D scanner to acquire the 3D point clouds of the taping part. Based on the digital 3D points cloud model of the part, we introduces a path planning method to generate the moving path of the systems. A rotary platform and a 6-DOF robot arm collaborate together to execute the robot taping process. For continuous taping, the system and method can handle Tubular shapes. Experiment of taping a cylindroid shape is conducted to validate the system and method. For parts with more complex geometry, further development on the automatic initial tape attaching and cutting mechanism is needed. With such system, the taping work can be much less troublesome. Also, the path planning method applies to applications such as drawing or writing on different surfaces etc. as well.
Rapamycin-Insensitive Up-Regulation of Adipocyte Phospholipase A2 in Tuberous Sclerosis and Lymphangioleiomyomatosis (2014)

Tuberous sclerosis syndrome (TSC) is an autosomal dominant tumor suppressor gene syndrome affecting multiple organs, including renal angiomyolipomas and pulmonary lymphangioleiomyomatosis (LAM). LAM is a female-predominant interstitial lung disease characterized by the progressive cyst formation and respiratory failure, which is also seen in sporadic patients without TSC. Mutations in TSC1 or TSC2 cause TSC, result in hyperactivation of mammalian target of rapamycin (mTOR), and are also seen in LAM cells in sporadic LAM. We recently reported that prostaglandin biosynthesis and cyclooxygenase-2 were deregulated in TSC and LAM. Phospholipase A2 (PLA2) is the rate-limiting enzyme that catalyzes the conversion of plasma membrane phospholipids into prostaglandins. In this study, we identified upregulation of adipocyte AdPLA2 (PLA2G16) in LAM nodule cells using publicly available expression data. We showed that the levels of AdPLA2 transcript and protein were higher in LAM lungs compared with control lungs. We then showed that TSC2 negatively regulates the expression of AdPLA2, and loss of TSC2 is associated with elevated production of prostaglandin E2 (PGE2) and prostacyclin (PGI2) in cell culture models. Mouse model studies also showed increased expression of AdPLA2 in xenograft tumors, estrogen-induced lung metastatic lesions of Tsc2 null leiomyoma-derived cells, and spontaneous renal cystadenomas from Tsc2+/- mice. Importantly, rapamycin treatment did not affect the expression of AdPLA2 and the production of PGE2 by TSC2-deficient mouse embryonic fibroblast (Tsc2-/-MEFs), rat uterine leiomyoma-derived ELT3 cells, and LAM patient-associated renal angiomyolipoma-derived "mesenchymal" cells. Furthermore, methyl arachidonyl fluorophosphate (MAFP), a potent irreversible PLA2 inhibitor, selectively suppressed the growth and induced apoptosis of TSC2-deficient LAM patient-derived cells relative to TSC2-addback cells. Our findings suggest that AdPLA2 plays an important role in promoting tumorigenesis and disease progression by modulating the production of prostaglandins and may serve as a potential therapeutic target in TSC and LAM.
Catalytic Asymmetric Epoxidation of α,β-Unsaturated Ketones Promoted by Lanthanoid Complexes (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTCatalytic Asymmetric Epoxidation of α,β-Unsaturated Ketones Promoted by Lanthanoid ComplexesMasahiro Bougauchi, Shizue Watanabe, Takayoshi Arai, Hiroaki Sasai, and Masakatsu ShibasakiView Author Information Faculty of Pharmaceutical Sciences, University of Tokyo Hongo, Bunkyo-ku, Tokyo 113, JapanCite this: J. Am. Chem. Soc. 1997, 119, 9, 2329–2330Publication Date (Web):March 5, 1997Publication History Received22 November 1996Published online5 March 1997Published inissue 1 March 1997https://pubs.acs.org/doi/10.1021/ja964037ohttps://doi.org/10.1021/ja964037orapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views3312Altmetric-Citations262LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Enones,Lanthanides,Organic reactions,Oxides Get e-Alerts
Deleteagene: a fast neutron deletion mutagenesis‐based gene knockout system for plants (2002)

Deleteagene (Delete-a-gene) is a deletion-based gene knockout system for plants. To obtain deletion mutants for a specific gene, random deletion libraries created by fast neutron mutagenesis are screened by polymerase chain reaction (PCR) using primers flanking the target gene. By adjusting the PCR extension time to preferentially amplify the deletion alleles, deletion mutants can be identified in pools of DNA samples with each sample representing more than a thousand mutant lines. In Arabidopsis, knockout plants for greater than 80% of targeted genes have been obtained from a population of 51,840 lines. A large number of deletion mutants have been identified and multiple deletion alleles are often recovered for targeted loci. In Arabidopsis, the method is very useful for targeting small genes and can be used to find deletion mutants mutating two or three tandem homologous genes. In addition, the method is demonstrated to be effective in rice as a deletion mutant for a rice gene was obtained with a similar approach. Because fast neutron mutagenesis is applicable to all plant genetic systems, Deleteagene has the potential to enable reverse genetics for a wide range of plant species.
Optimized CdS quantum dot-sensitized solar cell performance through atomic layer deposition of ultrathin TiO2 coating (2012)

Here we demonstrate a CdS quantum dot (QD) sensitized solar cell with significantly enhanced stability and depressed recombination in I−/I3− electrolyte. The CdS QDs were deposited in a mesoporous TiO2 film using chemical bath deposition. Following the coating of an ultrathin TiO2 protection layer using atomic layer deposition (ALD), the performance and stability of CdS QD sensitized solar cells were pronouncedly enhanced. Current–voltage measurements and electrochemical impedance spectroscopy analysis show that the ALD-TiO2 coating slows down the charge recombination and protects the QDs from the photocorrosion of the I−/I3− electrolyte. A systematic study shows that a ∼2 nm ALD-TiO2 layer can best promote solar cell efficiency by balancing protection with charge transfer. We have obtained a photoconversion efficiency of 1.41% and stable operation (no degradation in photocurrent) for at least 20 min under full sun illumination on CdS QD solar cells. The photocurrent gradually decreased down to ∼70% of its original value after 1 h of operation.
The Direct Activation of MIK, a Germinal Center Kinase (GCK)-like Kinase, by MARK, a Maize Atypical Receptor Kinase, Suggests a New Mechanism for Signaling through Kinase-dead Receptors (2003)

Signaling by receptor protein kinases (RPKs) involves their dimerization and transphosphorylation. However, atypical RPKs with kinase-defective domains have been described recently. Some of them are essential for proper signaling in animal systems, although the precise mechanism involved is unknown in most cases. Here we describe the cloning and characterization of an atypical plant receptor kinase from maize, MARK, which does not phosphorylate in vitro. A yeast two-hybrid approach has allowed us to identify a new germinal center kinase (GCK)-related protein, MIK, that interacts with MARK. Interestingly, the interaction of the intracellular domain of MARK with the regulator domain of MIK strongly induces MIK kinase activity. As some GCK-related proteins connect cell-surface receptors to the intracellular MAPK cascades, the activation of MIK by direct interaction with MARK could illustrate a new mechanism for signaling through atypical RPKs.
Wilson's Disease (1999)

Wilson's disease is a rare autosomal recessive inherited disorder of copper metabolism. Hepatic excretion of copper is impaired due to mutation of the gene for a copper-transporting adenosine triphosphatase, ATP7B. Copper accumulation in liver, brain, and other tissues may cause a wide spectrum of hepatic, neuropsychiatric, and other clinical manifestations. The diagnosis may be supported by measurement of serum ceruloplasmin, urinary copper excretion, and hepatic copper content as well as by detection of Kayser-Fleischer rings. Several treatments are available to increase urinary excretion and decrease intestinal absorption of copper.
Common Pharmacophores for Uncharged Human Ether-a-go-go-Related Gene (hERG) Blockers (2006)

In silico approaches are widely used to predict human ether-a-go-go-related gene (hERG) channel blockade. Published pharmacophore models of hERG blockers typically contain a basic nitrogen center flanked by aromatic or hydrophobic groups. However, hERG blockade has been observed in series lacking the basic nitrogen. By utilizing screening data for 194 potent uncharged hERG actives, we propose a pharmacophore for neutral hERG blockers, and provide guidance on eliminating hERG liability in an uncharged hERG active chemical series.
S2k guideline on diagnosis and treatment of atopic dermatitis — short version (2016)

Atopic dermatitis (AD) represents a pruritic, non-contagious, chronic or chronically relapsing, inflammatory skin disease. The course of the disease may be complicated by bacterial or viral superinfections. The first manifestation of the disease and further flare-ups are due to genetic predisposition and also to a variety of further trigger factors. The therapy regimen should be adapted to disease symptoms that are actually present and consider individual features of the disease as reported by the patients or their parents. This short version of the German guideline on AD provides an overview of evidence-based diagnostic and treatment options. All recommendations made here are the result of a consensus of the scientific medical societies, working groups and support groups based on scientific data published to date. Abstracts and details of the studies cited are provided in the long version of this guideline (see: www.awmf.org).
The effect of speckle filtering on scale-dependent texture estimation of a forested scene (2000)

Spatial fluctuations in microwave backscatter may be an important piece of information in discriminating tree stands. However, the presence of speckle in synthetic aperture radar (SAR) image data is a barrier to the exploitation of image texture. The authors explored a new methodology that combines a recent adaptive speckle reduction algorithm by Lopes et al. (1990) with a generic texture estimation scheme. They investigated the claim that this filter was capable of preserving backscatter texture. To understand if speckle reduction was destroying backscatter texture, they compared the strength of the relationship between forest inventory parameters and image texture as a function of spatial scale for both filtered and unfiltered images. They used Radarsat Fine mode image data: single look resolution is approximately 8.5 m, and pixel spacing is 3 m. Their study area was northern Vancouver Island, B.C., on the west coast of Canada. For the unfiltered data, they found that the ability of image texture to predict the forest parameters decreased as the texture scale increased from 3 to 13 m, suggesting greater information content in the small scale texture. For the filtered data, this relationship was much weaker at small scales and was not a function of distance. Their results suggest that the speckle filter was not retaining small scale texture, which is consistent with the theoretical hypotheses underlying its multiplicative noise model. They also show that there is significant information in small state SAR image texture that may be used as an adjunct to other spatial information for discriminating tree stands in the temperate rain forest.
Mining Criminal Networks from Chat Log (2012)

Cyber criminals exploit opportunities for anonymity and masquerade in web-based communication to conduct illegal activities such as phishing, spamming, cyber predation, cyber threatening, blackmail, and drug trafficking. One way to fight cyber crime is to collect digital evidence from online documents and to prosecute cyber criminals in the court of law. In this paper, we propose a unified framework using data mining and natural language processing techniques to analyze online messages for the purpose of crime investigation. Our framework takes the chat log from a confiscated computer as input, extracts the social networks from the log, summarizes chat conversations into topics, identifies the information relevant to crime investigation, and visualizes the knowledge for an investigator. To ensure that the implemented framework meets the needs of law enforcement officers in real-life investigation, we closely collaborate with the cyber crime unit of a law enforcement agency in Canada. Both the feedback from the law enforcement officers and experimental results suggest that the proposed chat log mining framework is effective for crime investigation.
A High-Throughput Method for the Quantitative Determination of Alliin* (1998)

The quality of most garlic (Allium sativum L., Alliaceae) preparations made from garlic powder or garlic dry extract is determined by their content of alliin. Therefore, a comprehensive documentation of alliin concentration beginning with the crude material up to the final remedy is required. The newly developed analytical method described in this paper was designed in order to fulfill these demands. In contrast to conventional HPLC methods, neither a pre-column derivatization nor a chromatographic separation are involved in this analytical procedure allowing a high throughput of samples. The currently investigated technique is based on immobilized alliinase (EC 4.4.1.4) which was combined with a two-channel flow injection analyser (FIA) coupled to an ammonia detecting device. A high specificity for alliin could be demonstrated and a variety of garlic samples including garlic powders, dry extracts, and garlic preparations was analysed. The results were in good correlation with those obtained by conventional HPLC methods.
ChemInform Abstract: A Search for Quantitative Acylation of α‐Trinositol (1D‐myo‐ Inositol 1,2,6‐Tris(dihydrogen Phosphate) Pentasodium Salt). (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Planar and van der Waals heterostructures for vertical tunnelling single electron transistors (2019)

Despite a rich choice of two-dimensional materials, which exists these days, heterostructures, both vertical (van der Waals) and in-plane, offer an unprecedented control over the properties and functionalities of the resulted structures. Thus, planar heterostructures allow p-n junctions between different two-dimensional semiconductors and graphene nanoribbons with well-defined edges; and vertical heterostructures resulted in the observation of superconductivity in purely carbon-based systems and realisation of vertical tunnelling transistors. Here we demonstrate simultaneous use of in-plane and van der Waals heterostructures to build vertical single electron tunnelling transistors. We grow graphene quantum dots inside the matrix of hexagonal boron nitride, which allows a dramatic reduction of the number of localised states along the perimeter of the quantum dots. The use of hexagonal boron nitride tunnel barriers as contacts to the graphene quantum dots make our transistors reproducible and not dependent on the localised states, opening even larger flexibility when designing future devices.
Blood viscosity in human obesity: relation to glucose tolerance and insulin status. (1989)

Obesity is known to be associated with an elevated risk for cardiovascular disease. Rheological disturbances could be factors contributing to these vascular complications. Therefore we have evaluated blood viscosity parameters in 128 obese (BMI greater than 28 kg/m2) adults and in 90 non-obese healthy subjects. Whole blood, plasma and erythrocyte viscosity values were determined with a Contraves LS30 viscosimeter. Plasma and whole blood viscosity were significantly (all P less than 0.001) increased in the obese subjects. The increased low shear erythrocyte viscosity suggested a diminished erythrocyte deformability in obesity. The rheological abnormalities were present even in the absence of impaired glucose tolerance, diabetes, hypertension or hyperlipidaemia. In the obese group the rheological parameters showed significant correlations (at least P less than 0.05) with BMI, insulin or C-peptide area during an oral glucose tolerance test and plasma lipids. Our findings demonstrate that obesity per se may be associated with abnormal blood viscosity properties.
Soil-Inhabiting Nematodes (1975)

Research Article| April 01 1975 Soil-Inhabiting Nematodes Richard S. Hussey, Richard S. Hussey Search for other works by this author on: This Site PubMed Google Scholar Ernest C. Bernard Ernest C. Bernard Search for other works by this author on: This Site PubMed Google Scholar The American Biology Teacher (1975) 37 (4): 224–233. https://doi.org/10.2307/4445183 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Richard S. Hussey, Ernest C. Bernard; Soil-Inhabiting Nematodes. The American Biology Teacher 1 April 1975; 37 (4): 224–233. doi: https://doi.org/10.2307/4445183 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe American Biology Teacher Search This content is only available via PDF. Copyright 1975 National Association of Biology Teachers Article PDF first page preview Close Modal You do not currently have access to this content.