gebhart/patrepeval huggingface dataset:
Synthesis of Nitroxide-Functionalized Polybutadiene Using Halogen-Containing Benzyloxyamine as Terminators for Anionic Polymerization. Volume 32, Number 1, January 12, 1999, pp 10−13. (1999)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionSynthesis of Nitroxide-Functionalized Polybutadiene Using Halogen-Containing Benzyloxyamine as Terminators for Anionic Polymerization. Volume 32, Number 1, January 12, 1999, pp 10−13.Seiya Kobatake, H. James Harwood, Roderic P. Quirk, and Duane B. PriddyCite this: Macromolecules 1999, 32, 26, 9080Publication Date (Web):December 8, 1999Publication History Published online8 December 1999Published inissue 1 December 1999https://pubs.acs.org/doi/10.1021/ma982407ihttps://doi.org/10.1021/ma982407icorrectionACS PublicationsCopyright © 1999 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views265Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (13 KB) Get e-AlertscloseSUBJECTS:Anionic polymerization Get e-Alerts
Eicosanoid forming enzyme mRNA in human tissues. Analysis by quantitative polymerase chain reaction (1991)

The key enzymes in the formation of eicosanoids, including leukocyte 5-lipoxygenase (5LX), platelet 12-lipoxygenase (12LX), reticulocyte 15-lipoxygenase (15LX), prostaglandin G/H synthase cyclooxygenase, and leukotriene A4 (LTA) hydrolase have been studied extensively in recent years. Little is known, however, about the regulation of these enzymes at the gene level. We have developed a quantitative polymerase chain reaction (PCR) assay to quantify the mRNAs for these five enzymes, as well as for cytoplasmic beta-actin (bACT) mRNA. Human erythroleukemia (HEL) cells, which display megakaryocytic/erythroid characteristics, were selected as a source of RNA to characterize the assay. These cells expressed mRNA for bACT, LTA, cyclooxygenase, and 12LX (in decreasing order). mRNA for 5LX and 15LX was undetectable. Bronchoalveolar lavage fluid cells obtained from asthmatic patients, primarily alveolar macrophages, contained mRNA for bACT, LTA, 5LX, cyclooxygenase, and 15LX (in decreasing order). Treatment of HEL cells with phorbol 12-myristate 13-acetate or steroid administration to asthmatic patients apparently selectively regulated certain of these target genes. The utility of this assay in quantifying mRNA for the various target genes in blood cells, including platelets from patients with chronic myelogenous leukemia, has also been demonstrated. Studies on the regulation of genes for enzymes involved in the leukotriene and prostaglandin biosynthetic pathways, especially when only small tissue samples are available, will be facilitated with this approach.
Bosutinib for the treatment of chronic myeloid leukemia in chronicphase (2012)

The clinical outcome for patients with chronic myeloid leukemia in chronic phase (CML-CP) is currently very favorable due to the availability of tyrosine kinase inhibitors (TKIs) that are well tolerated and effectively suppress the constitutively activated BCR-ABL1 kinase that underlies the pathogenesis of this malignancy. Three TKIs -imatinib, nilotinib and dasatinib- have been approved as frontline therapy in CML-CP. Another TKI, bosutinib, inhibits with high potency numerous tyrosine kinases, including BCR-ABL1, Src family of kinases and MAPK, among others. Like nilotinib and dasatinib, bosutinib is a second-generation TKI that inhibits the majority of mutations associated with imatinib resistance, with the exception of T315I. In patients with CML-CP with prior intolerance or resistance to imatinib therapy, bosutinib rendered response rates similar to those observed in the same patient population treated with nilotinib or dasatinib. Preliminary results from the ongoing phase III BELA study in which bosutinib is compared in a randomized fashion to imatinib for patients with newly diagnosed CML-CP have been recently reported. We herein summarize the preclinical and clinical experience of bosutinib in CML.
Cell surface changes and Rous sarcoma virus gene expression in synchronized cells. (1975)

We have investigated whether cell surface changes associated with growth control and malignant transformation are linked to the cell cycle. Chicken embryo cells synchronized by double thymidine block were examined for cell-cycle-dependent alterations in membrane function (measured by transport of 2-deoxyglucose, uridine, thymidine, and mannitol), in cell surface morphology (examined by scanning electron microscopy), and in the ability of tumor virus gene expression to induce a transformation-specific change in membrane function. We reach the following conclusions: (a) The high rate of 2-deoxyglucose transport seen in transformed cells and the low rates of 2-deoxyglucose and uridine transport characteristic of density-inhibited cells do not occur in normal growing cells as they traverse the cell cycle. (b) Although there are cell cycle-dependent changes in surface morphology, they are not reflected in corresponding changes in membrane function. (c) Tumor virus gene expression can alter cell membrane function at any stage in the cell cycle and without progression through the cell cycle.
Divine intervention in mental health (2010)

An abstract is not available for this content. As you have access to this content, full HTML content is provided on this page. A PDF of this content is also available in through the ‘Save PDF’ action button.
Identification of a Role for Apolipoprotein E Receptor 2 as a Platelet Receptor for Factor XI (2008)

Abstract Factor XI (FXI) promotes hemostasis and thrombosis through the enhancement of thrombin generation, and has been shown to play a critical role in the formation of occlusive thrombi in arterial injury models. Although the binding of FXI to platelets has been demonstrated, the role that FXI binding might play in platelet activation has not been studied. It is also unknown if FXI-platelet binding is solely mediated by GPIbα or if other platelet receptor(s) exist that can support interactions with FXI. This study has identified apolipoprotein E receptor 2 (ApoER2, LRP8), a member of the low-density lipoprotein (LDL) receptor family, as a platelet receptor for FXI. Surface-bound FXI supported platelet spreading and elevation of intracellular Ca2+, while platelet spreading on FXI was eliminated in the presence of either Src-kinase or PI3-kinase inhibitors. Platelet adhesion to immobilized FXI was abrogated in the presence of the universal LDL receptor antagonist, receptor-associated protein (RAP), soluble recombinant ApoER2′ or the LDL-binding domain 1 or 2 of ApoER2. FXI supported wild-type murine platelet binding; in contrast, ApoER2-deficient murine platelets did not adhere to FXI. Soluble FXI binding to immobilized platelets or purified recombinant ApoER2′ was abrogated in the presence of binding domain 1 of ApoER2 or RAP, respectively. These results identify FXI as a novel ligand for the platelet receptor ApoER2. While many of the details regarding the role of FXI in vivo are still undetermined, the ability of FXI to bind and activate platelets via ApoER2 suggests that FXI may contribute to hemostasis and thrombosis in a manner unrelated to contact activation or thrombin generation. Furthermore, these findings suggest that FXI may play a role in promoting cell signaling in other cells that express ApoER2, such as neurons, immune system cells and smooth muscle cells.
Matrix multiplication of data routing using a partitioned optical passive stars network (2000)

We develop optimal or near optimal algorithms to multiply matrices and perform commonly occurring data permutations and BPC permutations on multiprocessor computers interconnected by a partitioned optical passive stars network.
Recent advances on millimetre wave reconfigurable reflectarrays (2009)

This paper presents recent advances on reconfigurable reflectarrays at the University of Perugia. In particular the activities carried out in the framework of the European Network of Excellence AMICOM (Advanced MEMS for RF and MIllimeterwave COMmunications), those currently in progress within the FP7 project ARASCOM (‘MEMS & Liquid Crystal based’ Agile Reflectarray Antennas for Security & COMmunication) and the activities carried out in the framework of the recently started ESA Project RESKUE (Transportable REflectarray Antenna for Satellite KU-band Emergency Communications) will be illustrated. As for AMICOM outcomes, details of the design and fabrication of two reflectarrays operating at Ka-band will be provided, while innovative solutions and architectures for mm-wave imaging systems based on reflectarray antennas will be illustrated as work in progress within ARASCOM project. Concerning RESKUE project, the innovative solution proposed and the progress status will be illustrated. The theoretical basis for the accurate analysis and design of reconfigurable will be also provided, introducing a novel circuit model approach for an efficient analysis and optimized design of complex reconfigurable structures.
Wafer-level inspection system for the automated testing of comb drive based MEMS sensors and actuators (2010)

This work describes the design and experimental evaluation of a system for the non-contact testing of MEMS transducers on wafer level. The measurement principle is based on the optical detection of vibrating MEMS structures at their specific natural frequency. The working principle is demonstrated by testing a wafer with microfabricated microgrippers. Defective microgrippers are automatically identified.
Can 2015 be a transformative year for diagnostics in wound care? (2015)

Progress in wound care is slow at best. Often clinicians are slow to embrace and adopt new approaches to both treatment and diagnosis. Attempts have been made in recent times to provide diagnostic tools but the clinical community was slow to embrace them and added to their frustration, one significant barrier to adoption was that of funding. Payers and those responsible for reimbursement make it more difficult for wound care to progress by introducing significant ‘proof’ barriers. Can diagnostics turn the corner in 2015? Can we at last have a diagnostic suite that helps move wound care towards the clinical specialty it needs to be if progress is to be achieved in the management of the silent epidemic that will be upon the healthcare systems of the world? Most attempts at the provision of diagnostic tools, for wound carers, come from smaller more ‘start-up’ companies or from Universities, where funding for research and product support/registration is generally low. This poses significant time and financial pressures on organisations that do not necessarily have the means to provide the ‘burden of proof’ asked for by clinicians and regulators. So, little, if any, progress is likely unless we can change this environmental component to open innovation in this very important area, to ensure continued progress towards clinical specialization of wound care. Several players in the diagnostic arena have approached us to ask if a mechanism can be found to open the environment within wound care to better embrace diagnostics: To provide an environment where smaller players can work together leveraging the synergies of intellect, finances and resource to better serve their joint needs. Surely this is possible as we have seen such a collaboration in the area of infection with the advent of the International Wound Infection Institute. Perhaps we need the same in the diagnostics arena to move the environmental impactors into a more positive trajectory. Interested? If so we would like to hear from you, whether from the research, commercial or clinical arenas. If this is an area of interest for you then let us know and surely we can build some momentum to positively influence the research and development and subsequent clinical use of important tools for the care of patients with wounds.
Metabolic Instability of Myelin Proteins (1975)

Myelin basic protein, purified from bovine spinal cord, is cleaved by a purified bovine brain acid proteinase to yield three peptide fragments which were purified by gel filtration procedures combined with preparative gel electrophoresis. The purity of the fragments was established by end group analysis, amino acid analysis, polyacrylamide disc gel electrophoresis, and by their encephalitogenic activity. Chemical and biological characterization shows that one peptide, (peptide II), originates from the N‐terminal end of the basic protein and contains residues 1–43; a second peptide, (peptide I), contains residues 44–89 and a third peptide (peptide III). originates from the C‐terminal region with an N‐terminal phenylalanine, residue 90, through arginine, residue 170, of the basic protein. The combined amino acid composition of the three fragments account for the amino acid content of the basic protein. The structure of the three peptides demonstrates that the purified brain acid proteinase selectively cleaves the two phenylalanine‐phenylalanine linkages formed between residues 43–44 and 89–90 of the basic protein molecule. This study shows that cathepsin D could be the endogenous enzyme responsible for the breakdown of basic protein to form smaller encephalitogenic fragments, some of which are known to be present in crude tissue extracts.
Randomized clinical trial comparing octreotide and scopolamine butylbromide in symptom control of patients with inoperable bowel obstruction due to advanced ovarian cancer (2015)

At the doses used in this study, OCT was more effective than SB in controlling gastrointestinal symptoms of bowel obstruction. Further studies are necessary to understand the role of hydration more clearly in such a clinical situation.
REALTIME MONITORING OF PIPELINES FOR THIRD-PARTY CONTACT (2004)

Third-party contact with pipelines (typically caused by contact with a digging or drilling device) can result in mechanical damage to the pipe, in addition to coating damage that can initiate corrosion. Because this type of damage often goes unreported and can lead to eventual catastrophic failure of the pipe, a reliable, cost-effective method is needed for monitoring and reporting third-party contact events. The impressed alternating cycle current (IACC) pipeline monitoring method consists of impressing electrical signals on the pipe by generating a time-varying voltage between the pipe and the soil at periodic locations where pipeline access is available. The signal voltage between the pipe and ground is monitored continuously at receiving stations located some distance away. Third-party contact to the pipe that breaks through the coating changes the signal received at the receiving stations. In this project, the IACC monitoring method is being developed, tested, and demonstrated. Work performed to date includes a technology assessment, development of an IACC model to predict performance and assist with selection of signal operating parameters, and experimental measurements on a buried pipe at a test site. Initial results show that simulated contact can be detected. Future work will involve further refinement of the method and testing on operating pipelines.
Diels Alder Polyphenylene Anion Exchange Membrane for Nonaqueous Redox Flow Batteries (2015)

Here highly conductive, solvent-resistant anionic Diels Alder polyphenylene (DAPP) membranes were synthesized with three different ionic contents and tested in an ionic liquid-based nonaqueous redox flow battery (RFB). These membranes display 3–10× increase in conductivity in propylene carbonate compared to some commercially available (aqueous) anion exchange membranes. The membrane with an ion content of 1.5 meq/g (DAPP1.5) proved too brittle for operation in a RFB, while the membrane with an ion content of 2.5 meq/g (DAPP2.5) allowed excessive movement of solvent and poor electrochemical yields (capacity fade). Despite having lower voltage efficiencies compared to DAPP2.5, the membrane with an intermediate ion content of 2.0 meq/g (DAPP2.0) exhibited higher coulombic efficiencies (96.4% vs. 89.1%) and electrochemical yields (21.6% vs. 10.9%) after 50 cycles. Crossover of the electroactive species was the primary reason for decreased electrochemical yields. Analysis of the anolyte and catholyte revealed degradation of the electroactive species and formation of a film at the membrane-solution interface. Increases in membrane resistance were attributed to mechanical and thermal aging of the membrane; no chemical change was observed. As a result, improvements in the ionic selectivity and ionic conductivity of the membrane will increase the electrochemical yield and voltage efficiency of future nonaqueous redox flow batteries.
3D-printing soft sEMG sensing structures (2017)

This paper describes the development and characterization of soft and flexible 3D-printed sEMG electrodes. The electrodes are printed in one go on a low cost consumer multi-material FDM printer. The printed structures do not need any further production steps to give them conductive properties. Comparison between the gold standard Ag/AgCl gel electrodes and the printed EMG electrodes with a comparable contact area show that there is no significant difference in the EMG signal amplitude. The sensors are capable of distinguishing several levels of muscle activity of the biceps brachii. This all gives 3D-printed sEMG electrodes a high potential for creating personalized sensing structures, e.g. in prosthetic and orthotic contexts.
Direct CD1d-Mediated Stimulation of APC IL-12 Production and Protective Immune Response to Virus Infection In Vivo (2009)

CD1d-restricted NKT cells rapidly stimulate innate and adaptive immunity through production of Th1 and/or Th2 cytokines and induction of CD1d(+) APC maturation. However, therapeutic exploitation of NKT cells has been hampered by their paucity and defects in human disease. NKT cell-APC interactions can be modeled by direct stimulation of human APCs through CD1d in vitro. We have now found that direct ligation with multiple CD1d mAbs also stimulated bioactive IL-12 release from CD1d(+) but not CD1d knockout murine splenocytes in vitro. Moreover, all of the CD1d mAbs tested also induced IL-12 as well as both IFN-gamma and IFN-alpha in vivo from CD1d(+) but not CD1d-deficient recipients. Unlike IFN-gamma, CD1d-induced IFN-alpha was at least partially dependent on invariant NKT cells. Optimal resistance to infection with picornavirus encephalomyocarditis virus is known to require CD1d-dependent APC IL-12-induced IFN-gamma as well as IFN-alpha. CD1d ligation in vivo enhanced systemic IL-12, IFN-gamma, and IFN-alpha and was protective against infection by encephalomyocarditis virus, suggesting an alternative interpretation for previous results involving CD1d "blocking" in other systems. Such protective responses, including elevations in Th1 cytokines, were also seen with CD1d F(ab')(2)s in vivo, whereas an IgM mAb (with presumably minimal tissue penetration) was comparably effective at protection in vivo as well as cytokine induction both in vivo and in vitro. Although presumably acting immediately "downstream," CD1d mAbs were protective later during infection than the invariant NKT cell agonist alpha-galactosylceramide. These data indicate that NKT cells can be bypassed with CD1d-mediated induction of robust Th1 immunity, which may have therapeutic potential both directly and as an adjuvant.
Data collection with "UYANIK": too much pain; but gains are coming (2007)

In this paper, we present data collection activities and preliminary research findings from the real-world database collected with “UYANIK,” a passenger car instrumented with various sensors, CAN-Bus data logger, cameras, microphones, data acquisitions systems, computers, and support systems. Within the shared frameworks of DriveSafe Consortium (Turkey) and the NEDO (Japan) International Collaborative Research on Driving Behavior Signal Processing, close to 9 Terabytes of driver behavior, vehicular, and road data has been collected from more than 50 drivers on a 25 km route consisting of both city roads and highway in Istanbul, Turkey. Challenge of collecting data in a metropolis with around 12 million people, famous with extremely limited infrastructure yet driving behavior defying all rules and regulations bordering madness could not be “PAINLESS.” Both the experience gained and the preliminary results from still on-going studies using the database are very encouraging and give comfort.
Design Topics for Superconducting RF Cavities and Ancillaries (2014)

RF superconductivity has become a major subfield of accelerator science. There has been an explosion in the number of accelerator applications and in the number of laboratories engaged. The first lecture at this meeting of the CAS presented a review of fundamental design principles to develop cavity geometries to accelerate velocity-of-light particles ($β$ = v/c ~ 1), moving on to the corresponding design principles for medium-velocity (medium-$β$) and low-velocity (low-$β$) structures. The lecture included mechanical design topics. The second lecture dealt with input couplers, higher-order mode extraction couplers with absorbers, and tuners of both the slow and fast varieties.
Microbial and enzyme biotechnology: 21st century opportunities for greenhouse gas mitigation. (2004)

Clearance and re-entry of data, after the fact, as an individual conference paper at the request of Nancy Doran, HTL on 08/18/2005. PREVIOUSLY CLEARED AS (1) AN ABSTRACT UNDER PNNL-SA-39608 (2) BOOK/CONFERENCE PROCEEDINGS UNDER PNNL--SA-41487 INTRODUCTION-Ever-increasing atmospheric concentrations of greenhouse gases (GHG) presents a carbon management challenge of global and century-scale proportions if adverse environmental, economic, and social impacts of climate change are to be avoided. Integrated assessment models suggest that significant technological intervention is needed to transform how we produce and consume energy...