gebhart/patrepeval huggingface dataset:
Modulation of Cl- secretion by benzimidazolones. II. Coordinate regulation of apical GCl and basolateral GK (1996)

We previously demonstrated that the novel benzimidazolone, 1-ethyl-2-benzimidazolinone (1-EBIO), stimulates a sustained Cl- secretory response across T84 monolayers by opening a Ca(2+)-dependent basolateral K+ channel. In the present work, we evaluated the effects on Cl-secretion of other benzimidazolones, NS-004 and NS-1619, which have been shown to open cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels. In contrast to 1-EBIO, neither NS-004 nor NS-1619 stimulated a significant Cl- secretory current (Isc). Neither NS-004 nor NS-1619 increased Isc subsequent to forskolin stimulation. However, when added after 1-EBIO, NS-004 and NS-1619 stimulated large sustained increases in Isc. In addition, NS-004 and NS-1619 potentiated the effects of carbachol. We used nystatin to permeabilize the apical or basolateral membrane to determine the effects of NS-004 and 1-EBIO on the basolateral K+ (IK) and apical Cl- (ICl) currents. Both NS-004 and 1-EBIO increased ICl, and the stimulated currents were inhibited by glibenclamide. In contrast, NS-004 failed to significantly affect IK, but subsequent addition of 1-EBIO induced a large increase in IK. The effects of 1-EBIO, NS-004, and NS-1619 on the Ca(2+)-dependent K+ channel (KCa) in T84 cells was determined in excised inside-out patches. Neither NS-004 nor NS-1619 affected K+ channel activity, whereas the subsequent addition of 1-EBIO produced a marked channel activation. Results similar to those observed in T84 monolayers were obtained from murine airway cell primary cultures: NS-004 or NS-1619 had no effect on Isc, whereas 1-EBIO stimulated a sustained Cl- secretory response. The results demonstrate that activation of CFTR alone is insufficient to evoke transepithelial Cl- secretion. Activation of the basolateral membrane K+ channel is a necessary component of the secretory response. Thus the basolateral membrane KCa may be a novel pharmacological target in cystic fibrosis therapy.
Strengthen The Quality Management of Sudden Environmental Pollution Emergency Monitoring (2006)

This article mainly expounds that strengthening the quality management is the most important role of sudden environmental pollution emergency monitoring. In accordance with each links of sudden environmental pollution emergency monitoring, quality management from two sides——daily quality control and field quality control, ensure the accuracy monitoring data.
Criterion for excipients screening in the development of nanoemulsion formulation of three anti-inflammatory drugs (2009)

The present study was undertaken for screening of different excipients in the development of nanoemulsion formulations of three anti-inflammatory drugs namely ketoprofen, celecoxib (CXB) and meloxicam. Based on solubility profiles of each drug in oil, Triacetin (ketoprofen and CXB) and Labrafil (meloxicam) were selected as the oil phase. Based on maximum solubilization potential of oil in different surfactants, Cremophor-EL (ketoprofen and CXB) and Tween-80 (meloxicam) were selected as surfactants. Based on maximum nanoemulsion region in the pseudoternary phase diagrams, Transcutol-HP was selected as cosurfactant for all three drugs. 1:1 (ketoprofen and CXB) and 2:1 (meloxicam) mass ratio of surfactant to cosurfactant was selected for selection of different nanoemulsions on the basis of maximum nanoemulsion region in the phase diagrams. All selected nanoemulsion formulations were found thermodynamically stable. Results of these studies showed that all excipients were properly optimized for the development of nanoemulsion formulation of ketoprofen, CXB and meloxicam.
Radical pericardiectomy for chronic constrictive pericarditis (2018)

Radical pericardiectomy provided superior 10-year survival and clinical functional improvement in patients with chronic constrictive pericarditis compared to sub-total pericaridectomy.
High activation of Sb during solid-phase epitaxy and deactivation during subsequent thermal process (2003)

Ion-implanted Sb is activated with higher concentrations than at thermal equilibrium during solid phase epitaxy, this Sb being deactivated at thermal equilibrium during the subsequent thermal process. It seems that Sb is trapped at the lattice sites at values above solid solubility during solid phase epitaxy and the diffusion of dopants degrades the resistance, as dopants begin to aggregate and deactivate. We showed that the onset of the increase in resistance is related to the diffusion length of Sb. By using a thermal process before deactivation, we could obtain shallow junctions with low resistance.
Trust in Mediated Interactions (2009)

This article presents a brief overview of the background of trust research and its relevance. It then introduces a framework for trust in mediated interactions that draws on existing models and findings, and applies this to human trust in other humans, organizations (e.g., e-commerce vendors), and technology (e.g., websites). Beyond incorporating variables related to the trusting and the trusted actor, the framework accommodates key contextual factors. Rather than treating trustworthiness as a relatively stable attribute of the trusted actor, the framework considers how trustworthiness is influenced by these contextual factors. This framework will help researchers in aligning disparate research findings and it may be a step towards building a theory of trust in human-computer interactions. For designers, the benefit lies in helping them to fully explore the available design space of systems fostering trust in mediated interactions.
Genetic control of stem-cell properties and stem cells in aging (2003)

Studies to uncover genes regulating stem cells usually adopt one of two distinct lines of investigation: forward genetics and reverse genetics approaches. The forward genetics approach proceeds from measurable phenotypic differences to genetic polymorphism and, as the name implies, the path of investigation is reversed using reverse genetics. The number of newly discovered loci responsible for stem cell-specific phenotypes and functioning is increasing at a rapid rate owing to the success of both approaches. These loci regulate stem cells by intrinsic (cell autonomous) and/or extrinsic mechanisms and dictate stem-cell fate decisions. During the aging process, stem cells undergo both quantitative and qualitative changes, which are hypothesized to affect both the rate of aging and the longevity of an organism.
Semantic novelty modulates neural responses to visual change across the human brain (2023)

Our continuous visual experience in daily life is dominated by change. Previous research has focused on visual change due to stimulus motion, eye movements or unfolding events, but not their combined impact across the brain, or their interactions with semantic novelty. We investigate the neural responses to these sources of novelty during film viewing. We analyzed intracranial recordings in humans across 6328 electrodes from 23 individuals. Responses associated with saccades and film cuts were dominant across the entire brain. Film cuts at semantic event boundaries were particularly effective in the temporal and medial temporal lobe. Saccades to visual targets with high visual novelty were also associated with strong neural responses. Specific locations in higher-order association areas showed selectivity to either high or low-novelty saccades. We conclude that neural activity associated with film cuts and eye movements is widespread across the brain and is modulated by semantic novelty.
Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content (2020)

Rare genetic diseases preponderantly affect the nervous system causing neurodegeneration to neurodevelopmental disorders. This is the case for both Menkes and Wilson disease, arising from mutations in ATP7A and ATP7B, respectively. The ATP7A and ATP7B proteins localize to the Golgi and regulate copper homeostasis. We demonstrate genetic and biochemical interactions between ATP7 paralogs with the conserved oligomeric Golgi (COG) complex, a Golgi apparatus vesicular tether. Disruption of <i>Drosophila</i> copper homeostasis by ATP7 tissue-specific transgenic expression caused alterations in epidermis, aminergic, sensory, and motor neurons. Prominent among neuronal phenotypes was a decreased mitochondrial content at synapses, a phenotype that paralleled with alterations of synaptic morphology, transmission, and plasticity. These neuronal and synaptic phenotypes caused by transgenic expression of ATP7 were rescued by downregulation of COG complex subunits. We conclude that the integrity of Golgi-dependent copper homeostasis mechanisms, requiring ATP7 and COG, are necessary to maintain mitochondria functional integrity and localization to synapses.<b>SIGNIFICANCE STATEMENT</b> Menkes and Wilson disease affect copper homeostasis and characteristically afflict the nervous system. However, their molecular neuropathology mechanisms remain mostly unexplored. We demonstrate that copper homeostasis in neurons is maintained by two factors that localize to the Golgi apparatus, ATP7 and the conserved oligomeric Golgi (COG) complex. Disruption of these mechanisms affect mitochondrial function and localization to synapses as well as neurotransmission and synaptic plasticity. These findings suggest communication between the Golgi apparatus and mitochondria through homeostatically controlled cellular copper levels and copper-dependent enzymatic activities in both organelles.
Incremental SAT Instance Generation for SAT-based ATPG (2008)

Due to ever increasing design sizes more efficient tools for automatic test pattern generation (ATPG) are needed. Recently ATPG based on Boolean satisfiability (SAT) has been shown to be a beneficial complement to traditional ATPG techniques. This paper makes two contributions. Firstly, we analyze the two steps SAT-based ATPG consists of with respect to their run time on industrial benchmarks. Secondly, exploiting these analysis results, we propose an incremental solving technique with the objective to speed up the entire classification process. An experimental evaluation of the proposed method shows a significant reduction of the overall run time of the SAT- based ATPG process.
Imaging Serpiginous Choroidopathy With Spectral Domain Optical Coherence Tomography (2008)

The use of spectral domain optical coherence tomography (SD-OCT) in the study of chronic serpiginous choroiditis was evaluated. Two patients with chronic serpiginous choroiditis were imaged using two prototype SD-OCT systems (6-microm axial resolution). Raster scans covering 6 x 6 X 2-mm regions of the retina were obtained, enabling the study of different retinal cross-sectional images. Thickness maps were obtained after segmentation of retinal layers, which could be compared with those on follow-up. SD-OCT allowed the visualization of the cross-sectional retinal architecture at different horizontal positions. Superimposition of SD-OCT generated reconstructed fundus images with fundus photographs provided accurate images registration. Segmentation of retinal layers provided thickness maps and higher-density improved visualization of photoreceptor layer, cysts, and atrophy, which was useful in following change in disease activity over time. The researchers concluded that SD-OCT is a useful tool to study disease morphology and follow-up of chronic serpiginous choroiditis.
Study of solid–liquid interface in water dispersions of microcrystalline celluloses (2008)

Interaction on the solid–liquid surface in dispersions of microcrystalline cellulose (MCC) with various particle sizes has been studied by means of rheological methods. It was shown that the MCC dispersions possess shear-thinning rheological properties. An inversely proportional relationship between the average particle size of the MCC particles and the viscosity of the dispersions was discovered. This phenomenon is explained by the decrease of water mobility with increase in the specific surface of the MCC particles. Irreversible closing of the MCC pores reduces the viscosity of water dispersions. Addition of some water-soluble polymers leads to a considerable increase in viscosity due to formation of macromolecular net composed of solid particles.
Hepatocellular Carcinoma in South America: Evaluating Factors for Curative Therapy and Survival (2016)

Introduction: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Most studies have focused on characterizing patients with HCC in Europe, North America, and Asia. However, little is known about the underlying demographic characteristics and risk factors for HCC in South America. Methods: This study is a retrospective cohort study aimed at identifying the risk factors and demographics of HCC in South America. Participating centers completed a templated, retrospective chart review of patient characteristics at the time of HCC diagnosis. Results: Fourteen centers from six countries contributed data for an aggregate 1,336 patients. Brazil accounted for 40% of patients, Argentina 19%, Colombia 18%, Peru 16%, Ecuador 5% and Uruguay 2%. The median age at diagnosis was 64 years and 68% were male. The most common risk factor for HCC was HCV (48%), followed by alcoholic cirrhosis (22%), HBV (14%), NAFLD (9%) or other (8%). Other subgroups included 727 patients with treatment data and 241 patients with survival data. Logistic regression models showed absence of cirrhosis (OR 3.96, 95% CI 2.09-7.44, p= < 0.001), diagnosis with HCC surveillance (OR 2.21, 95% CI 1.43-3.47, p= < 0.001) and AFP < 200ng/ml at the time of diagnosis (OR 2.29, 95% CI 1.25-4.24, p=0.007) were predictive of receiving curative therapy. NAFLD, gender, AFP < 20ng/ml, age, HBV, HCV and alcoholic liver disease were not significant. A COX proportional hazards model showed significant improvements in survival were associated with screening (RR 1.62, 95% CI 1.28-2.07, P= < 0.001), age (RR 1.01, 95% CI 1.00-1.02, p=0.025) and HCV (RR 1.35, 95% CI 1.01-1.80, p=0.042). Covariates, including HBV, alcoholic liver disease, NAFLD, cirrhosis, AFP level and curative therapy were not significant. Conclusion: Our study is the largest cohort to date reporting demographics, risk factors, and outcomes of HCC patients across South America. We found that patients without cirrhosis, patients with an AFP < 200ng/ml or patients who were diagnosed on screening were more likely to receive curative therapy as defined by surgical resection, radiofrequency ablation, alcohol ablation or liver transplant. We also showed that age, screening protocol use and underlying HCV were independently associated with prolonged survival.
Reduced Nonlinear Microwave Effects in YBaCuO Resonators on a Polarized $\hbox{SrTiO}_{3}$ Thin Layer (2009)

The combination of oxides may yield the elaboration of heterostructures with new or multifunctional properties. With such a philosophy, YBaCuO superconducting thin films were grown on top of a thin SrTiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> paraelectric layer to observe the interaction between their respective microwave nonlinearities. The SrTiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> layer was characterized by measuring the quality factor ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ) of slot meander line resonators at 6 GHz and 77 K. DC biasing the paraelectric significantly improves the resonator linear and nonlinear response. This paper shows how the saturation of the nonlinear dielectric constant(epsiv <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> ) and loss tangent (tandelta) in the paraelectric reduces the nonlinearities.
Coordinate-Free Distributed Localization and Circumnavigation for Nonholonomic Vehicles Without Position Information (2021)

This article studies the localization and circumnavigation problem concerned with a cluster of nonholonomic vehicles independently of a uniform global coordinate. Particularly, the clustered vehicles collaboratively locate an unknown target and then circumnavigate it isometrically with desired distance and velocity. However, the vehicles have no access to any position information, including their own absolute positions and others’ relative positions. Instead, they are capable of measuring relative bearings only with respect to their neighbors within their local coordinates. Different local coordinates are not necessarily aligned. Moreover, only some of the vehicles can measure relative bearings with respect to the target. For the solution to the concerned localization and circumnavigation problem, a coordinate-free distributed algorithm composed by two parts is proposed. To be specific, the first distributed localization part guarantees that the vehicles accurately estimate the relative positions with respect to the target and neighbors given a persistently exciting condition. And the second distributed circumnavigation part further guarantees that the vehicles move around the target estimation isometrically with the desired distance and velocity. Also, the necessary persistently exciting condition is shown to be met. Finally, simulation and experiment are both given to confirm the effectiveness of the proposed distributed algorithm.
SECONDARY ATTRACTION IN THE WESTERN BALSAM BARK BEETLE, DRYOCOETES CONFUSUS (COLEOPTERA: SCOLYTIDAE) (1983)

Abstract Evidence for secondary attraction in the western balsam bark beetle, Dryocoetes confusus Swaine, was obtained in laboratory bioassays and field experiments. Both sexes showed positive responses to volatiles of the host tree, Abies lasiocarpa (Hook.) Nutt., indicating that primary attraction is probably important in host selection by this species. Male beetles initiated attack and within 6 h produced an aggregation pheromone(s), which was present in frass and in pentane extracts of the abdomens of males excised from logs. Both sexes responded to the pheromone. Abdominal extract of unmated males which had bored into host bark for 14 days was still attractive. Pheromone production was induced by exposing males to host resin volatiles. Mating had no effect on male attractiveness, but induced females to produce an antiaggregation pheromone which, in laboratory bioassays, at least partially inhibited response to male attractant. The attractive volatiles from male-infested logs were successfully captured on Porapak Q ® . The development of laboratory bioassay and pheromone extraction techniques indicates that a pheromone isolation program is feasible.
Evidence based medicine: clinical trials that guide the management of ST-elevation myocardial infarction of elderly patients (2006)

Cardiovascular disease is the most frequent diagnosis in elderly people and is the leading cause of death in both men and women older than 65 years. Every year in the United States more than 700,000 patients arrive at the emergency room with ST-segment elevation myocardial infarction(STEMI). About 60 percent of hospital admissions for AMI are of people older than 65 years. Their in-hospital, 1-month,and 1-year mortality is high. 1 In this article, we will provide a review on clinical trials that guide the management of STelevation myocardial infarction of the elderly patients.……
Quantum key distribution with 1.25 Gbps clock synchronization (2004)

Clock recovery techniques at 1.25 Gbps enable continuous quantum key distribution at demonstrated sifted-key rates exceeding 1 Mbps. This rate is two orders of magnitude faster than has been reported previously, and serves to enhance both the data encryption capabilities and the distance over which a QKD system can operate. Full-text article is not available.
Human Carcinoma Cells Synthesize and Secrete Tenascin in vitro (1992)

Tenascin is an extracellular matrix glycoprotein produced in response to epithelial-mesenchymal interactions that initiate fetal organogenesis, and it is also found in the stroma of benign and malignant neoplasms. Thirty-five human cell lines representing a variety of cancers were examined by immunoprecipitation and polyacrylamide gel electrophoresis of radiolabeled tenascin proteins from conditioned media. Two forms of tenascin with relative molecular masses of 190,000 and 250,000 were identified. Eight cell lines produced both forms. With the exception of myeloid and lymphoid leukemias and Burkitt's lymphoma, all of the mesodermal and neuroectodermal tumor lines were found to synthesize tenascin. Unexpectedly, tenascin was secreted by several mammary and colonic adenocarcinomas as well as by a line derived from normal mammary epithelial cells, and in some cases increased production was induced by transforming growth factor beta in serum-free medium. Cells producing fibronectin but not tenascin attached and spread on plastic culture dishes, while those producing tenascin alone remained suspended in the medium or were rarely attached. Tenascin also inhibited fibronectin-mediated adhesion of MCF7 breast carcinoma cells in vitro. The results suggest that tenascins synthesized and secreted by some cancer cells, especially those of epithelial origin, may have specific roles in determining tumor cell adhesion and ultimately the ability to form invasive outgrowths.
Active object detection on graphs via locally informative trees (2016)

Active object detection refers to the problem of determining the existence and location of objects in an image by actively selecting which regions of the image to explore. Herein, an object detection algorithm is proposed that models image regions as vertices and overlap relationships as edges in a directed weighted graph. Information is propagated from labeled vertices through graph edges that operate as noisy channels via message passing over locally informative trees that are extracted from the original graph using an information-theoretic criterion. Influential vertices are determined by an appropriate centrality index. Our algorithm can be applied on top of any state-of-the-art region proposal method as it treats it as a black box. The effectiveness of the proposed algorithm is illustrated on different scenarios, where in some cases only 0.45% of the total regions is evaluated.
Activities of Antioxidant Enzymes in Various Tissues of Male Fischer 344 Rats Are Altered by Food Restriction (1995)

The objective of this study was to determine how food restriction (40% restriction of food intake) altered the age-related changes in the activities of Cu,Zn superoxide dismutase, catalase and glutathione peroxidase in liver, brain cortex, heart, kidney and intestinal mucosa obtained from 6-, 16- and 26-mo-old male Fischer 344 rats. Food restriction increased the activity of one or more of the antioxidant enzymes in the liver, brain cortex, heart and kidney of the rats. However, the magnitude of the effect and the antioxidant enzyme(s) affected by food restriction varied from tissue to tissue, and food restriction had no significant effect on the activities of these enzymes in intestinal mucosa. Interestingly, the four tissues in which food restriction increased the activity of one or more of the antioxidant enzymes showed reduced lipid peroxidation as measured by thiobarbituric acid-reactive material. These data suggest that food restriction might enhance the survival of rodents by altering the levels of the antioxidant enzymes and hence reducing free radical damage.