gebhart/patrepeval huggingface dataset:
Data from PROTOCADHERIN 7 Acts through SET and PP2A to Potentiate MAPK Signaling by EGFR and KRAS during Lung Tumorigenesis (2023)

&lt;div&gt;Abstract&lt;p&gt;Non–small cell lung cancer (NSCLC) is the leading cause of cancer-associated deaths worldwide. Given the efficacy of membrane proteins as therapeutic targets in human malignancies, we examined cell-surface receptors that may act as drivers of lung tumorigenesis. Here, we report that the PROTOCADHERIN PCDH7 is overexpressed frequently in NSCLC tumors where this event is associated with poor clinical outcome. PCDH7 overexpression synergized with EGFR and KRAS to induce MAPK signaling and tumorigenesis. Conversely, PCDH7 depletion suppressed ERK activation, sensitized cells to MEK inhibitors, and reduced tumor growth. PCDH7 potentiated ERK signaling by facilitating interaction of protein phosphatase PP2A with its potent inhibitor, the SET oncoprotein. By establishing an oncogenic role for PCDH7 in lung tumorigenesis, our results provide a rationale to develop novel PCDH7 targeting therapies that act at the cell surface of NSCLC cells to compromise their growth. &lt;i&gt;Cancer Res; 77(1); 187–97. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Blood Volume and Haemoglobin Oxygen Content Changes in Human Bone Marrow during Orthostatic Stress (2006)

The interest in, and the need for effective measures to be used in screening, diagnosis, and the follow-up of skeletal pathologies is growing markedly. This paper proposes a completely new and non-invasive technique allowing the study of the human tibia bone marrow (BM) haemodynamics with a time resolution of 1 s. The technique, based on near infrared spectroscopy, is sensitive enough to allow the detection of BM blood volume and/or oxygen saturation changes during orthostatic variations imposed by a tilt bed. An increase in the slope of the bed of 15 degrees is sufficient to detect this phenomenon. The ability to study the possible presence of a neural control of BM haemodynamics is also discussed. No other existing technique currently allows one to obtain the proposed results and this approach might open up a new field of study related to human BM physiology.
Human Work Support Technology Utilizing Sensor Data (2020)

In response to problems associated with the shortage of factory workers, the demand for efficiency maximization by eliminating wasted work has recently become stronger. Moreover, to ensure compliance with product quality, the demand for reliable work execution is also increasing. Conventionally, productivity has fallen because workers must manually enter a system to start and finish work. To circumvent this, we have developed advanced human work techniques, “automatic switching of work instruction screen” and “real-time work deviation detection”, by utilizing deep learning technology. Compared to conventional approaches, we achieved a 15% reduction in product assembly time and a deviation detection leak of almost zero (more than 95% work identification accuracy).
A low molecular weight (12–15kDa) protein fraction in rat liver binds alpha-tocopherol (1993)

Conference Article| November 01 1993 A low molecular weight (12–15kDa) protein fraction in rat liver binds alpha-tocopherol DEREK J. LEISHMAN; DEREK J. LEISHMAN 1Division of Biochemical Sciences, Rowett Research Institute, Aberdeen, AB2 9SB, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar FIONA M. CAMPBELL; FIONA M. CAMPBELL 1Division of Biochemical Sciences, Rowett Research Institute, Aberdeen, AB2 9SB, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar MARGARET-J. GORDON; MARGARET-J. GORDON 1Division of Biochemical Sciences, Rowett Research Institute, Aberdeen, AB2 9SB, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar GARRY G. DUTHIE; GARRY G. DUTHIE 1Division of Biochemical Sciences, Rowett Research Institute, Aberdeen, AB2 9SB, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar ASIM K. DUTTA-ROY ASIM K. DUTTA-ROY * *To whom correspondence should be addressed. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1993) 21 (4): 408S. https://doi.org/10.1042/bst021408s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation DEREK J. LEISHMAN, FIONA M. CAMPBELL, MARGARET-J. GORDON, GARRY G. DUTHIE, ASIM K. DUTTA-ROY; A low molecular weight (12–15kDa) protein fraction in rat liver binds alpha-tocopherol. Biochem Soc Trans 1 November 1993; 21 (4): 408S. doi: https://doi.org/10.1042/bst021408s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1993 Biochemical Society1993 Article PDF first page preview Close Modal You do not currently have access to this content.
[A case of AGC with pCR after preoperative chemotherapy including S-1 plus cisplatin]. (2010)

A 79-year-old man complaining of epigastralgia was examined and diagnosed with advanced gastric cancer (UML, Type 5, Ant-Less-Gre, cT4a, cN1, cH0, cP1, cStage IV). A poor prognosis was predicted, but we tried preoperative chemotherapy hoping for a down-staging of the tumor. We chose a regimen of S-1 plus cisplatin as follows: S-1 (60 mg/m2) was administered orally for 3 weeks followed 2 weeks of rest, and cisplatin (50 mg/m2) was administered by intravenous drip on day 8. After three cycles of treatment, diagnostic laparoscopic examination revealed a suspected serosal invasion of the main tumor, but peritoneal dissemination was not seen, and abdominal washing cytology was negative. After the fourth cycle of treatment, total gastrectomy with lymph node dissection (D1+No. 7, 8a, 9, R0) was performed. Histological examination of the resected specimens revealed no residual cancer cells in the primary lesion or regional lymph nodes, resulting in a diagnosis of complete response to chemotherapy according to the Japanese Classification of Gastric Carcinoma. The postoperative course was uneventful, and he has been fine as an outpatient.
Sowing the Protein Seeds of Prion Propagation (2000)

Ever since Prusiner first proposed his radical "protein-only" hypothesis to explain how certain infectious proteins (prions) are transmitted from one mammal to another in the absence of DNA or RNA, scientists have been trying to prove him right (or wrong). The study of mammalian prions, such as those causing Creutzfeldt-Jakob disease in humans, scrapie in sheep and mad cow disease in cattle, has been slow to yield answers. However, as Tuite discusses in his Perspective, the Sup35p and Ure2p proteins of yeast that exist in both normal and infectious forms are providing evidence that the "protein-only" hypothesis may be right (Sparrer et al.).
Compilation and Correlation of Limiting Activity Coefficients of Nonelectrolytes in Water (1996)

The phase equilibria of dilute aqueous solutions are treated separately from those of dilute organic systems due to water's unique structure and hydrogen-bonding characteristics. As a result, traditional predictive methods (UNIFAC, ASOG, etc.) tend to be only moderately successful. In addition to inverse solubility measurements, we describe new direct and indirect techniques for precisely measuring these values which are more accurate. A database is compiled from data measured by using these techniques. The data were evaluated and suspect points removed. The data were correlated linearly with the solute solvatochromic α, β, and π*, solute and solvent molar volume, solute vapor pressure, and the solute gas−liquid partition coefficient between hexadecane and an inert gas phase, log L16. The correlation fits the data to within an average absolute deviation of 0.294 ln units. The correlation provides a direct and relatively accurate method for estimating Henry's constants and thus limiting activity coefficients of nonelectrolytes in water.
Feasibility study on a novel daylighting system with embedded micro compound parabolic concentrators (CPCs) (2018)

A novel glazing system consisting of a polymer layer with embedded micro compound parabolic concentrators (CPCs), which is attached to a glass pane of glazing, is proposed. It aims to reduce the energy consumption due to cooling in buildings, provide daylighting, and maintain the transparent view. In the present work, the daylighting system is modelled for ray-tracing simulation, and the angular-dependent transmittance at the azimuth angle of 0&deg; is calculated. Structural characterization is conducted using optical microscope for the microstructures which serve as support for the reflective thin films of a micro CPC. Based on self-shading effect of a microstructure, facet-selective deposition of Aluminum with various thickness has been achieved by physical vapor deposition. Spectral measurement has been used to characterize the optical properties of the Aluminum thin films. Diffraction effect with respect to the thin film thickness on the transmission of linear micro-CPCs arrays is investigated by a monochromatic laser beam and visual observation. The results of the present work provides the reference for the optimization of the transmittance of the deposited thin film for a micro CPC, in order to achieve the desired optical property.
High-Temperature, High-Density Plasma Production by Vortex-Ring Compression (1978)

The TRISO PS III machine at the University of Miami has been modified by improving the preionization of the plasma and increasing the ring frequency of the conical $\ensuremath{\theta}$-pinch coils. The secondary magnetic compression field has been increased to 120 000 G at the conjugate points of the mirror. It has been possible, with this modified machine, TRISO PS IV, to obtain ion temperatures of 5 keV with corresponding electron temperature of less than 300 eV. The electron density was 2\ifmmode\times\else\texttimes\fi{}${10}^{17}$ ${\mathrm{cm}}^{\ensuremath{-}3}$. This plasma was held in stable equilibrium for 5 \ensuremath{\mu}sec.
A randomised controlled trial to compare local with general anaesthesia for short-stay inguinal hernia repair. (1982)

A series of 117 consecutive unselected patients with clinically reducible unilateral inguinal herniae were admitted for short-stay repair. Seven expressed a strong preference for one form of anaesthesia (6 general (GA)) local (LA) and 7 were unfit for GA; these were excluded from the trial. The remaining 103 patients were allocated at random to receive either LA or GA in order to compare the two methods of anaesthesia. The resulting groups (53 LA, 50 GA) were well matched for age and obesity. Perand postoperative symptoms were assessed with linear analogues self-assessment questionnaires. Statistically significant differences were demonstrated between the groups; those patients having LA were able to walk, eat, and pass urine earlier than those having GA, who experienced more nausea, vomiting, sore throat, and headache. The postoperative course and additional symptoms were otherwise similar. Forty-five LA patients experienced mild pain during the operation, but nevertheless 85% of the total group said they would consent to its use again. Ninety-three patients (90%) were discharged at 24 h. LA was applicable to all types of clinically reducible inguinal hernia and was an acceptable, safe, and satisfactory alternative to GA.
Terminating Electrolyte (2019)

Recommendations are given concerning the terminology of methods of separation in analytical chemistry, including chromatography, electromigration techniques, and field-flow fractionation and related techniques.
Reprogramming of connexin landscape fosters fast gap junction intercellular communication in human papillomavirus-infected epithelia (2023)

Human papillomaviruses (HPVs) are highly prevalent commensal viruses that require epithelial stratification to complete their replicative cycle. While HPV infections are most often asymptomatic, certain HPV types can cause lesions, that are usually benign. In rare cases, these infections may progress to non-replicative viral cycles associated with high HPV oncogene expression promoting cell transformation, and eventually cancer when not cleared by host responses. While the consequences of HPV-induced transformation on keratinocytes have been extensively explored, the impact of viral replication on epithelial homeostasis remains largely unexplored. Gap junction intercellular communication (GJIC) is critical for stratified epithelium integrity and function. This process is ensured by a family of proteins named connexins (Cxs), including 8 isoforms that are expressed in stratified squamous epithelia. GJIC was reported to be impaired in HPV-transformed cells, which was attributed to the decreased expression of the Cx43 isoform. However, it remains unknown whether and how HPV replication might impact on the expression of Cx isoforms and GJIC in stratified squamous epithelia. To address this question, we have used 3D-epithelial cell cultures (3D-EpCs), the only model supporting the productive HPV life cycle. We report a transcriptional downregulation of most epithelial Cx isoforms except Cx45 in HPV-replicating epithelia. At the protein level, HPV replication results in a reduction of Cx43 expression while that of Cx45 increases and displays a topological shift toward the cell membrane. To quantify GJIC, we pioneered quantitative gap-fluorescence loss in photobleaching (FLIP) assay in 3D-EpCs, which allowed us to show that the reprogramming of Cx landscape in response to HPV replication translates into accelerated GJIC in living epithelia. Supporting the pathophysiological relevance of our observations, the HPV-associated Cx43 and Cx45 expression pattern was confirmed in human cervical biopsies harboring HPV. In conclusion, the reprogramming of Cx expression and distribution in HPV-replicating epithelia fosters accelerated GJIC, which may participate in epithelial homeostasis and host immunosurveillance.
Water Purification and Oyster Culture Reconstruction in Closed Sea Area Using Micro Bubble Technology (2012)

The program of research and development on the reconstruction support from the Great East Japan Earthquake on the base of the collaboration of college of technology was conducted using micro bubble technology for the water purification and the recovery of oyster culture in Ofunato Bay. The compact, lightweight and energy-saving devices having instrumentation system of 104 micro bubble generators were developed to carry out the purification and the culture. The micro bubbles in Takonoura water area of Ofunato Bay were supplied continuously during 8 months. Oyster growth-promoting was achieved by the supply of micro bubbles in Ofunato Bay and a new cultivation method of the oyster using micro bubble technology was found by the growth.
EARLY EXTUBATION IN CHILDREN AFTER REPAIR OF ATRIAL SEPTAL DEFECT (1990)

Hillier, S. C. MB, FFARCS; Taylor, R. H. MB, FFARCS; Burrows, F. A. MD, FRCPC Author Information
Development of a Synchronous Enzyme-Reaction System for a Highly Sensitive Enzyme Immunoassay (2002)

A synchronous enzyme-reaction system using water-soluble formazan and a non-enzymatic electron mediator was developed and applied to an enzyme immunoassay (EIA). The reaction system consists of four steps: (I) dephosphorylation of NADP(+) to produce NAD(+) by alkaline phosphatase (ALP), (II) reduction of NAD(+) to produce NADH with oxidation of ethanol to yield acetaldehyde by alcohol dehydrogenase (ADH), (III) reduction of water-soluble tetrazolium salt (WST-1) to produce formazan by NADH via 1-methoxy-5-methyl-phenazinium methyl sulfate (PMS), and (IV) re-reduction of NAD(+) to produce NADH by ADH. During each cycle, one molecule of tetrazolium is converted to one molecule of formazan. The concentration of formazan during the reaction was given by second-order polynomials of the reaction time. Kinetic studies strongly suggested that the synchronous enzyme-reaction system had the potential to detect an analyte at the attomole level in EIA. On the basis of the kinetic studies, optimal conditions for EIA incorporating the synchronous system were examined. NADP(+) was purified thoroughly to remove minor traces of NAD(+) in the preparation, and an ADH preparation contaminated with the lowest level of ALP activity was used. When the synchronous system was applied to a sandwich-type EIA for human C-reactive protein, the protein was detected with a sensitivity of 50 attomole per well of a micro-titer plate (0.1 ml) in a 1-h reaction. In addition, EIA with water-soluble formazan showed a more quantitative and sensitive result than that with insoluble formazan. These findings indicated that the (WST-1)-PMS system introduced in this study has a great potential for highly sensitive enzyme immunoassay.
Time-scale effects during damage evolution: A fractal approach based on acoustic emission (2005)

In this paper we propose a fractal theory for the prediction of the time-effects on the damage evolution in cracking solids. By means of the Acoustic Emission (AE) technique, we have analysed the evolution of damage in several structures by an extensive experimental analysis in time. This technique permits to estimate the amount of energy released during fracture propagation and to obtain information on the criticality of the ongoing process. Theory and experiments agree closely. Moreover, based on fractal concepts, we have formulated a multiscale criterion to predict the damage progress in concrete structural elements. According to this method, the damage level of a structure can be estimated from AE data of a reference specimen extracted from the structure and tested up to failure. By monitoring the fracture propagation by AE, it is therefore possible to evaluate the damage level of a structure as well as the time corresponding to final collapse. Consequently, the life-time predictions of monitored solid structures can be estimated: as an example we have analysed the evolution of damage in two piers supporting a viaduct along an Italian highway built in the 1950s.
Distributed Mobility Management for a Flat Architecture in 5G Mobile Networks: Solutions, Analysis and Experimental Validation (2015)

In the last years, the commercial deployment of data services in mobile networks has been evolving quickly, providing enhanced radio access technologies and more efficient network architectures. Nowadays, mobile users enjoy broadband and ubiquitous wireless access through their portable devices, like smartphones and tablets, exploiting the connectivity offered by the modern 4G network. Nevertheless, the technological evolution keeps moving towards the development of next generation networks, or 5G, aiming at further improving the current system in order to cope with the huge data traffic growth foreseen in the future years.\nOne of the possible research guidelines aims at innovating the mobile networks architecture by designing a flat system. Indeed, current systems are built upon a centralized and hierarchical structure, where multiple access networks are connected to a central core hosting crucial network functions, e.g., charging, control and maintenance, as well as mobility management, which is the main topic of this thesis. In such a central mobility management system, users’ traffic is aggregated at some key nodes in the core, called mobility anchors. Thus, an anchor can easily handle user’s mobility by redirecting traffic flows to his/her location, but i) it poses scalability issues, ii) it represents a single point of failure, and iii) the routing path is in general suboptimal. These problems can be overcome moving to a flat architecture, adopting a Distributed Mobility Management (DMM) system, where the centralized anchor is removed.\nThis thesis develops within the DMM framework, presenting the design, analysis, implementation and experimental validation of several DMM protocols. In this work we describe original protocols for client-based and network-based mobility management, as well as a hybrid solution. We study analytically our solutions to evaluate their signaling cost, the packet delivery cost, and the latency introduced to handle a handover event.\nFinally, we assess the validity of some of our protocols with experiments run over a network prototype built in our lab implementing such solutions.
A critical state sand plasticity model accounting for fabric evolution (2013)

Fabric and its evolution need to be fully considered for effective modeling of the anisotropic behavior of cohesionless granular sand. In this study, a three-dimensional anisotropic model for granular material is proposed based on the anisotropic critical state theory recently proposed by Li & Dafalias [2012], in which the role of fabric evolution is highlighted. An explicit expression for the yield function is proposed in terms of the invariants and joint invariants of the normalized deviatoric stress ratio tensor and the deviatoric fabric tensor. A void-based fabric tensor that characterizes the average void size and its orientation of a granular assembly is employed in the model. Upon plastic loading, the material fabric is assumed to evolve continuously with its principal direction tending steadily towards the loading direction. A fabric evolution law is proposed to describe this behavior. With these considerations, a non-coaxial flow rule is naturally obtained. The model is shown to be capable of characterizing the complex anisotropic behavior of granular materials under monotonic loading conditions and meanwhile retains a relatively simple formulation for numerical implementation. The model predictions of typical behavior of both Toyoura sand and Fraser River sand compare well with experimental data. Copyright © 2013 John Wiley & Sons, Ltd.
Design, Construction, and Analysis of an Ultra-Low Expansion Quartz Resonant Cavity Passive Ring Resonator Laser Gyroscope. (1982)

Abstract : The purpose of this research is to design and build a Passive Ring Resonator Laser Gyroscope (PRLG) that is small in size, constructed from a thermally stable material, and utilizes a laser cavity--resonant cavity mode match design. The small size design is dominated by the physical size of the available components; consequently, the small design is as small as physically possible with these components. The dimensions of the PRLG are as follows: (1) the perimeter of the reson ant cavity is 45.2 cm., (2) the laser cavity is 22 cm. long, and (3) the distance from the center of the laser cavity to the input mirror of the resonant cavity is 49.664 cm. The thermally stable material obtained for the PRLG is a block of Ultra-Low Expansion Quartz (ULE Quartz). The coefficient of thermal expansion for ULE Quartz is 0.55 x 10 to the minus 6th power cm./cm./C, thus making this material a very thermally stable material. Due to the configuration and size of this ULE Quartz block, only the resonant cavity portion of the PRLG is formed using the ULE Quartz block. The laser cavity--resonant cavity mode matching design is accomplished in three steps. First, the spot size of the resonant cavity beam is determined at some point outside the resonant cavity. Second, the laser is designed such that its spot size is identical to the spot size of the resonant cavity beam at that same point. Third, the radius of curvature of the external corner mirror required to change the radius of curvature of the laser cavity beam into the radius of curvature of the resonant cavity beam is determined.