gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Crystallization of Sodium Birnessite and Accompanied Phase Transformation. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Local Antinociceptive Actions of Nonsteroidal Antiinflammatory Drugs in the Mouse Radiant Heat Tail-Flick Test (2007)

Local, but not systemic, administration of NSAIDs produced antinociception in the tail-flick thermal assay. The endogenous opioid system contributes to the peripheral antinociceptive effects of dipyrone, but not to that of diclofenac, ketorolac, lysine acetyl salicylate, or sodium salicylate, suggesting differences in the mechanisms of action among the NSAIDs.
Facile large-area photolithography of periodic sub-micron structures using a self-formed polymer mask (2012)

This letter reports the methodology of a low-cost fabrication technique for producing periodic sub-micron structures over a large area, using a polymer mask. A thin film of gold/palladium or silica is deposited on a stretched polydimethylsiloxane (PDMS) substrate. Release of the tension forms a buckling sinusoidal pattern on the surface. The PDMS substrates are then used as masks in soft contact optical lithography, bypassing the need for an expensive lithographic process toward creating regular patterns on a traditional masks. Pattern transfers are conducted using an ultraviolet lamp and the fabrication of more complex periodic structures through multiple exposures is reported.
KIDNEY TRANSPLANTATION WITH CAMPATH 1H AND INFLIXIMAB INDUCTION FOLLOWED BY EITHER TACROLIMUS OR SIROLIMUS MONOTHERAPY: 12-MONTHS FOLLOW-UP (2010)

Viklicky, O.1; Slatinska, J.2; Volk, H.3; Sawitzki, B.4; Burgelova, M.5; Reinke, P.6 Author Information
A Symbiotic Digital Signage system based on display to display communication (2015)

Digital signage (DS) has become a phraseology for recent technology, is gaining massive acceptance to the technology-dependent world. Though the development of DS includes the essence of advertisement purposes, the fusion strategy makes it promising for communication technology. This paper demonstrates a Symbiotic Digital Signage (SDS) system in which one display of DS can be used to communicate with other displays of DS. Data are transmitted to the displays using the steganography process which encircles the display to display communication using the camera on display during the video broadcasting simultaneously. The data hidden in video images are retrieved by analyzing the temporal sequential frame of the same image. The steganography process combines data in images in which the discrete time cosine transform (DCT) is used rather than wavelet transform (WT) because of its obvious advantages over the WT. The performance analysis has been shown with respect to the structural similarity (SSIM) of image, peak signal to noise ratio (PSNR), mean square error (MSE) of combined RGB color and MSE of the RGB color separately.
Yokukansan Inhibits Neuronal Death during ER Stress by Regulating the Unfolded Protein Response (2010)

Our results indicate that Yokukansan, Senkyu and ferulic acid are protective against ER stress-induced neuronal cell death and may provide a possible new treatment for AD.
Recursive Computation of the Generalized Q Function (1973)

A recursive method of computing values of the generalized Q function is described. The Q function is also interpreted in terms of noncentral chi-square distributed random variables, and in terms of the difference between Poisson random variables.
Effect of HIV on survival in patients with non-small-cell lung cancer in the era of highly active antiretroviral therapy: a population-based study (2012)

US National Cancer Institute (award number UC2CA148310).
New wafer-level-packaging technology using silicon-via-contacts for optical and other sensor applications (2004)

Wafer-level-packaging has been proven in numerous applications as the optimal packaging solution for microelectronic devices. In the field of sensors and MEMS, packaging cost is still the major expense factor. In this paper, a new packaging technology, which is a combination of wafer-level-packaging (WLP) and MEMS processing technology is presented. With a strong focus on optical applications, the basic processing steps to form a unique wafer-level-package for sensor and MEMS devices is discussed.
New DC/DC converter with low output voltage and fast transient response (2003)

A new alternative to get fast transient response DC/DC switching converters is presented in order to feed devices such as microprocessors and DSPs. The topology of the switching power supply is composed of two buck converters connected in parallel, each one of them with different aims, controlled by means of the linear-nonlinear control. In this paper, the LNL control is reviewed and applied to the proposed power supply (fast response double buck, FRDB). Also, experimental results are obtained to show the main features of the proposed converter and to compare them with the features of some other solution.
In Vitro Methods for the Assessment of L-Cysteine Conjugate Toxicity (1994)

L-Cysteine conjugates are normally metabolised via N-acetylation to produce a mercapturic acid. However, a recently identified metabolic route (C-S lysis) may lead to the generation of an unstable thiol which has been demonstrated to be responsible for toxicity in various mammalian species. Human Chang liver cells were challenged with a number of established L-cysteine conjugates. The cellular toxicity of these compounds was determined using a range of assay procedures, which provided differing information, depending on the assay method used. These observations were then investigated in order to establish which system would provide the most reliable indication of C-S lyase toxicity and whether any information on the mechanism of action could be obtained by these assay methods.
Acid Ribonuclease in Rat Prostate During Castration-Induced Involution1 (1980)

The activity of acid ribonuclease (RNase) in the ventral prostate of rats was measured at different intervals following castration. The specific activity (units/mg protein) in the prostate of noncastrated rats was relatively low and increased gradually, though not significantly, through the first 3 days after castration. The enzyme activity reached a maximal level between Days 5 and 7 (P<0.01), then decreased gradually, and returned to the precastration level by Day 14. Subcutaneous injection of actinomycin D at 50 μg/day to castrated rats for 4 or 5 consecutive days retarded the rate of prostatic regression and was accompanied by a significant reduction in RNase activity in the prostate. These results indicate that elevated specific activity of RNase coincided with the period of rapid prostatic regression and that this elevation in enzyme activity can be suppressed by actinomycin D.
Citizen Green #1 Well: Quantitative XRD & Thin Section Data (2022)

This submission includes information on quantitative x-ray diffraction measurements and thin section photography conducted on sidewall cores from the Citizen Green #1 well drilled on King Island, CA (API 07720688) as part of the WESTCARB partnership basin characterization effort. Cores were acquired with a rotary sidewall tool at a range of depths; only deeper cores were sufficiently consolidated for analysis. SidewallCoreFormationDepthNotes.xls provides details on available samples. Helium porosimetry, air permeability, and brine permeability measurements were conducted on all competent samples (~15). Samples were largely in the Mokelumne, H&amp;T shale, and Starkey formations. All measurements were conducted at Lawrence Berkeley National Laboratory.
Safety and Feasibility of an Immersive Virtual Reality Intervention Program for Teaching Police Interaction Skills to Adolescents and Adults with Autism (2020)

Low-cost, wireless immersive virtual reality (VR) holds significant promise as a flexible and scalable intervention tool to help individuals with autism spectrum disorder (ASD) learn and develop critical practical life skills, including interacting safely and effectively with police officers. Previous research suggests that VR is a motivating intervention platform, but many individuals with ASD also exhibit anxiety and sensory sensitivities which might make it difficult to tolerate VR experiences. Here, we describe the results of a relatively large-scale, National Institutes of Health-funded systematic examination of the safety, feasibility, and usability of an immersive VR training program in adolescents and adults with ASD, aged 12 and older. Sixty verbally fluent individuals with no personal or immediate family history of seizures or migraines participated in either one (n = 30) or three 45-min (n = 30) VR sessions using a lightweight wireless headset, and were monitored for side effects. Participants also reported on system usability, enjoyment, and willingness to engage in further VR sessions. Results confirm that immersive VR is safe, feasible, and highly usable for verbally fluent adolescents and adults with ASD. LAY SUMMARY: Immersive virtual reality (VR) holds promise as a means to provide social skills interventions for individuals with autism spectrum disorder (ASD), but it is unclear whether associated anxiety and sensory symptoms might limit feasibility. Here, we report data that indicate that immersive VR is both safe and feasible for use in verbally fluent adolescents and adults with ASD, for up to three 45-min sessions. Autism Res 2020, 13: 1418-1424. © 2020 International Society for Autism Research, Wiley Periodicals, Inc.
Generation of Pure Oxygen from Briny Water by Binary Catalysis (2023)

Whereas the emphasis of water splitting is typically on hydrogen generation, there is value in the oxygen produced, especially in the undersea environment and for medicinal applications in the developing world. The generation of pure and breathable oxygen from abundant and accessible sources of water, such as brine and seawater, is challenging owing to the prevalence of the competing halide oxidation reaction to produce halogen and hypohalous acids. We show here that pure O<sub>2</sub> may be generated from briny water by using an oxygen evolution catalyst with an overlayer that fulfills the criteria of (i) possessing a point of zero charge that results in halide anion rejection and (ii) promoting the disproportionation of hypohalous acids.
Structure-property relationships of fluorinated carboxylic acid bioisosteres (2023)

Fluorinated alcohols and phenols are potentially useful as bioisosteres of the carboxylic acid functional group. To enable a direct comparison of the properties of fluorinated carboxylic acid surrogates with those of other commonly used, non-fluorinated bioisosteres, we conducted a structure-property relationship (SPR) study based on matched molecular pair (MMP) analyses. A series of representative examples have been characterized by experimentally determining physicochemical properties, such as acidity (pK<sub>a</sub>), lipophilicity (logD<sub>7.4</sub>), and permeability (PAMPA). The results presented can help estimate the relative changes in physicochemical properties that may be attainable by replacing the carboxylic acid functional group with fluorine containing surrogate structures.
Transcriptomic and Genetic Associations between Alzheimer’s Disease, Parkinson’s Disease, and Cancer (2021)

Alzheimer's (AD) and Parkinson's diseases (PD) are the two most prevalent neurodegenerative disorders in human populations. Epidemiological studies have shown that patients suffering from either condition present a reduced overall risk of cancer than controls (i.e., inverse comorbidity), suggesting that neurodegeneration provides a protective effect against cancer. Reduced risks of several site-specific tumors, including colorectal, lung, and prostate cancers, have also been observed in AD and PD. By contrast, an increased risk of melanoma has been described in PD patients (i.e., direct comorbidity). Therefore, a fundamental question to address is whether these associations are due to shared genetic and molecular factors or are explained by other phenomena, such as flaws in epidemiological studies, exposure to shared risk factors, or the effect of medications. To this end, we first evaluated the transcriptomes of AD and PD post-mortem brain tissues derived from the hippocampus and the substantia nigra and analyzed their similarities to those of a large panel of 22 site-specific cancers, which were obtained through differential gene expression meta-analyses of array-based studies available in public repositories. Genes and pathways that were deregulated in both disorders in each analyzed pair were examined. Second, we assessed potential genetic links between AD, PD, and the selected cancers by establishing interactome-based overlaps of genes previously linked to each disorder. Then, their genetic correlations were computed using cross-trait LD score regression and GWAS summary statistics data. Finally, the potential role of medications in the reported comorbidities was assessed by comparing disease-specific differential gene expression profiles to an extensive collection of differential gene expression signatures generated by exposing cell lines to drugs indicated for AD, PD, and cancer treatment (LINCS L1000). We identified significant inverse associations of transcriptomic deregulation between AD hippocampal tissues and breast, lung, liver, and prostate cancers, and between PD substantia nigra tissues and breast, lung, and prostate cancers. Moreover, significant direct (same direction) associations of deregulation were observed between AD and PD and brain and thyroid cancers, as well as between PD and kidney cancer. Several biological processes, including the immune system, oxidative phosphorylation, PI3K/AKT/mTOR signaling, and the cell cycle, were found to be deregulated in both cancer and neurodegenerative disorders. Significant genetic correlations were found between PD and melanoma and prostate cancers. Several drugs indicated for the treatment of neurodegenerative disorders and cancer, such as galantamine, selegiline, exemestane, and estradiol, were identified as potential modulators of the comorbidities observed between neurodegeneration and cancer.
Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias. (1994)

The t(1;19) chromosomal translocation is observed in pre-B cell acute lymphoblastic leukemias and results in expression of chimeric E2A-PBX1 proteins that contain transcriptional activation domains from E2A and the homeodomain of PBX1. Since homeodomains mediate DNA-binding, a potential model for the action of E2A-PBX1 is that it disrupts the transcriptional regulation of genes normally controlled by PBX1 or its closely-related family members PBX2 or PBX3. Using a binding site selection assay, we identified a consensus nucleotide sequence ATCAATCA specifically bound by the PBX1 homeodomain and those of its closely-related family members PBX2 and PBX3. An endogenous protein with the properties of PBX3b specifically bound to this sequence in nuclear extracts of precursor B cells. Transfection of reporter genes containing PBX binding sites linked to a minimal promoter demonstrated transactivation by E2A-PBX1 fusion protein dependent upon presence of the homeodomain. In contrast, wild-type PBX proteins were incapable of activating transcription. The striking differences in transcriptional properties of fusion and wild-type PBX proteins provides strong functional evidence for the importance of aberrant transcriptional regulation in the genesis of t(1;19)-bearing leukemias.
Prospective Randomized Evaluation of High Power During CLOSE-Guided Pulmonary Vein Isolation (2020)

This randomized controlled study shows that a 45 W radiofrequency power CLOSE protocol in patients with paroxysmal AF significantly increases the global procedural efficiency with similar midterm efficacy. However, our study showed a narrower safety margin and a limited increased efficiency at the posterior wall using high power. This advocates against the use of high power in the region neighboring the esophagus.
The Potential for Digestate Thickening in Biogas Plants and Evaluation of Possible Evaporation Methods (2016)

Rising number of biogas plants (BGP) is associated with a rising amount of digestate, which is a by-product of biogas production. Liquid digestate (LD) is produced in mechanical separation of digestate, and contains valuable nutrients as well as large amounts of water. Treatment of the LD is thus rather expensive for the plant owners. One of the ways to drain the LD and obtain valuable concentrated nutrients is vacuum evaporation. Vacuum evaporation allows to utilize low-potential waste heat which occurs in excessive amounts in BGP. The potential for digestate thickening is further discussed. This paper also compares specific heat consumption and other selected parameters of three types of industrial evaporators, which may be suitable for the LD thickening. Presented results shows that the proposed model of MSF evaporator has the best thermal performance.
A Duplication and Loop Checking Free System for S4 (1996)

Most of the sequent/tableau based proof systems for the modal logic S4 need to duplicate formulas and thus are required to adopt some method of loop checking. In what follows we present a tableau-like proof system for S4, based on D'Agostino and Mondadori's classical KE, which is free of duplication and loop checking. The key feature of this system (let us call it KES4) consists in its use of (i) a label formalism which models the semantics of the modal operators according to the usual conditions for S4; and (ii) a label unification scheme which tells us when two labels "denote" the same world in the S4-model(s) generated in the course of proof search. Moreover, it uses special closure conditions to check models for putative contradictions.
Benchmarking emergency department triage prediction models with machine learning and large public electronic health records (2021)

The demand for emergency department (ED) services is increasing across the globe, particularly during the current COVID-19 pandemic. Clinical triage and risk assessment have become increasingly challenging due to the shortage of medical resources and the strain on hospital infrastructure caused by the pandemic. As a result of the widespread use of electronic health records (EHRs), we now have access to a vast amount of clinical data, which allows us to develop predictive models and decision support systems to address these challenges. To date, however, there are no widely accepted benchmark ED triage prediction models based on large-scale public EHR data. An open-source benchmarking platform would streamline research workflows by eliminating cumbersome data preprocessing, and facilitate comparisons among different studies and methodologies. In this paper, based on the Medical Information Mart for Intensive Care IV Emergency Department (MIMIC-IV-ED) database, we developed a publicly available benchmark suite for ED triage predictive models and created a benchmark dataset that contains over 400,000 ED visits from 2011 to 2019. We introduced three ED-based outcomes (hospitalization, critical outcomes, and 72-hour ED reattendance) and implemented a variety of popular methodologies, ranging from machine learning methods to clinical scoring systems. We evaluated and compared the performance of these methods against benchmark tasks. Our codes are open-source, allowing anyone with MIMIC-IV-ED data access to perform the same steps in data processing, benchmark model building, and experiments. This study provides future researchers with insights, suggestions, and protocols for managing raw data and developing risk triaging tools for emergency care.
Collaborative multi-vehicle localization and mapping in marine environments (2010)

This paper explains an application scenario of collaborative multi-vehicle simultaneous localization and mapping algorithm (CSLAM) in a marine environment using autonomous surface crafts (ASCs) in order to validate its performance. The motivation behind this is that a team of ASCs can explore a marine environment more efficiently and reliably than a single ASC. However use of multiple ASCs poses additional scaling problems such as inter-vehicle map fusion, and data association which needs to be addressed in order to be viable for various types of missions. In this paper we first demonstrate the steps of extending the single vehicle extended kalman filter based simultaneous localization and mapping (EKF-SLAM) approach to the multi-vehicle case. Performance of the algorithm is first evaluated using simulations and then using real data extracted from actual sea trials conducted in the littoral waters of Singapore (Selat Puah) using two ASCs. GPS data is used to assess the accuracy of localization and feature estimations of CSLAM algorithm. The improvements that can be achieved by using multiple autonomous vehicles in oceanic environments are also discussed.
Impact of permanent magnet field on inductance variation of a PMLSM (2007)

Analytical models of Surface Mounted Permanent Magnet Linear Synchronous Motors are generally presented with constant inductances. However, the impact of powerful rare-earth PMs in the saturation phenomena cannot be neglected anymore. In this paper, a new non-linear model of PMLSM inductances is suggested. This model is defined as a function of the current value as well as of the magnet position. So, an analytical study, a finite-element analysis and experimental results are presented and confronted.
Measurements with silicon photomultipliers of dose-rate effects in the radiation damage of plastic scintillator tiles in the CMS hadron endcap calorimeter (2020)

Measurements are presented of the reduction of signal output due to radiation damage for two types of plastic scintillator tiles used in the hadron endcap (HE) calorimeter of the CMS detector. The tiles were exposed to particles produced in proton-proton (pp) collisions at the CERN LHC with a center-of-mass energy of 13 TeV, corresponding to a delivered luminosity of 50 fb −1 . The measurements are based on readout channels of the HE that were instrumented with silicon photomultipliers, and are derived using data from several sources: a laser calibration system, a movable radioactive source, as well as hadrons and muons produced in pp collisions. Results from several irradiation campaigns using 60 Co sources are also discussed. The damage is presented as a function of dose rate. Within the range of these measurements, for a fixed dose the damage increases with decreasing dose rate.