gebhart/patrepeval huggingface dataset:
Atomic-Scale Structure of Mo6S6 Nanowires (2008)

We have studied the atomic-scale structure of the Mo6S6 nanowires using scanning tunneling microscopy and spectroscopy (STM and STS) and density functional theory (DFT). A novel synthesis route based on metallic Mo precursors is presented for the selective formation of elementary pure Mo6S6 nanowires. The Mo6S6 nanowires selectively organize as trimer bundles, and each of the Mo6S6 nanowires consists of an electrically conducting Mo backbone dressed with a sulfur exterior cap. The Mo6S6 nanowires may thus be of interest as novel building blocks in nanoelectronics because the Mo6S6 nanowires exist in a robust, singular structural conformation with uniquely defined electrical (metallic) properties.
A Reactive Bearing Angle Only Obstacle Avoidance Technique for Unmanned Ground Vehicles (2014)

In this paper, we present a reactive, vision based obstacle avoidance technique for Unmanned Ground Vehicles (UGVs) navigating with only visual electro-optic sensors in an indoor environment without Global Positioning System (GPS) signals. The presented work is unique in that, to the best of our knowledge, there was no other bearing angle only obstacle avoidance technique for ground vehicles reported in the literature. A Lyapunov-based sliding mode controller maintains the bearing angle of the UGV from obstacles, using a real-time image processing method. The proposed technique is implemented and tested with a Pioneer robot in an indoor environment, and the results demonstrate its effectiveness.
Supplementary Figure 2 from A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent (2023)

&lt;p&gt;PDF file - 280K, A) Chemical structures of PES and synthesized derivatives. P=pyrrolidine; CM= carboxymethyl; Cl=chloride. B) MTT cell viability analyses of H1299 and PANC1 cells after 48 hour treatment with 10 uM PES, PES-P, PES-PCM and PES-PCl. The values shown are the averaged results from three independent experiments, and error bars mark standard deviations. C) Immunoblot analysis of H1299 cells following treatment with 10 uM of the compounds indicated for the timepoints indicated, using antisera to the autophagy (p62SQSTM1 and LC3) and apoptosis (cleaved lamin A) markers indicated, as well as HSP70 and actin (control). The arrows mark monomeric and oligomeric forms of p62SQSTM1, as well as cleaved and lipidated forms of LC3 I and II.&lt;/p&gt;
A Versatile Computer Method for Computation of Conductor Temperatures in Cable Terminations and Pipe Cable Systems (1985)

A computer method, originally developed for the determination of ampacity and ratings of cable. terminations, has been expanded to cover also the thermal analysis for accurate ratings of underground pipe-type cables. The versatile computer method is able. to handle many situations where the traditional methods are either inaccurate or too complex. The main advantage of the method is its ability tp provide fast solutions in abnormal emergency situations where the traditional methods will tend to produce incorrect ratings. The new computer method will. also be of substantial value in evaluation of new underground pipe-type cable systems or similar installations.
Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets (2005)

Bone marrow-derived mesenchymal stem cells (BM-MSCs) are stromal cells with the ability to proliferate and differentiate into many tissues. Although they represent powerful tools for several therapeutic settings, mechanisms regulating their migration to peripheral tissues are still unknown. Here, we report chemokine receptor expression on human BM-MSCs and their role in mediating migration to tissues. A minority of BM-MSCs (2% to 25%) expressed a restricted set of chemokine receptors (CXC receptor 4 [CXCR4], CX3C receptor 1 [CX3CR1], CXCR6, CC chemokine receptor 1 [CCR1], CCR7) and, accordingly, showed appreciable chemotactic migration in response to the chemokines CXC ligand 12 (CXCL12), CX3CL1, CXCL16, CC chemokine ligand 3 (CCL3), and CCL19. Using human pancreatic islets as an in vitro model of peripheral tissue, we showed that islet supernatants released factors able to attract BM-MSCs in vitro, and this attraction was principally mediated by CX3CL1 and CXCL12. Moreover, cells with features of BM-MSCs were detected within the pancreatic islets of mice injected with green fluorescent protein (GFP)-positive BM. A population of bona fide MSCs that also expressed CXCR4, CXCR6, CCR1, and CCR7 could be isolated from normal adult human pancreas. This study defines the chemokine receptor repertoire of human BM-MSCs that determines their migratory activity. Modulation of homing capacity may be instrumental for harnessing the therapeutic potential of BM-MSCs.
Sequence-Specific Recognition of DNA Oligomer Using Peptide Nucleic Acid (PNA)-Modified Synthetic Ion Channels: PNA/DNA Hybridization in Nanoconfined Environment (2010)

Here we demonstrate the design and construction of a simple, highly sensitive and selective nanofluidic sensing device, based on a single synthetic conical nanochannel for the sequence specific detection of single-stranded DNA oligonucleotides. The biosensing performance of the device depends sensitively on the surface charge and chemical groups incorporated on the inner channel wall that act as binding sites for different analytes. Uncharged peptide nucleic acid (PNA) probes are covalently immobilized on the channel surface through carbodiimide coupling chemistry. This diminishes the channel surface charge, leading to a significant decrease in the rectified ion current flowing through the channel. The PNA-modified channel acts as a highly specific and selective device for the detection of a complementary single-stranded DNA sequence. Upon PNA/DNA hybridization, the channel surface charge density increased due to the presence of the negatively charged DNA strand. The changes in the surface charge-dependent current-voltage (I-V) curves and rectification ratio of the channel confirm the success of immobilization and PNA/DNA hybridization within a confined space at the nanoscale. In addition, a control experiment indicated that the biosensor exhibits remarkable specificity toward a cDNA strand and also has the ability to discriminate single-base mismatch DNA sequences on the basis of rectified ion flux through the nanochannel. In this context, we envision that the single conical nanochannels functionalized with a PNA probe will provide a biosensing platform for the detection and discrimination of short single-stranded DNA oligomer of unknown sequence.
Hot-Fire Testing of a 1N AF-M315E Thruster (2015)

This hot-fire test continues NASA investigation of green propellant technologies for future missions. To show the potential for green propellants to replace some hydrazine systems in future spacecraft, NASA Marshall Space Flight Center (MSFC) is continuing to embark on hot-fire test campaigns with various green propellant blends. NASA completed a hot-fire test of a 1N AF-M315E monopropellant thruster at the Marshall Space Flight Center in the small altitude test stand located in building 4205. The thruster is a ground test article used for basic performance determination and catalyst studies. The purpose of the hot-fire testing was for performance determination of a 1N size thruster and form a baseline from which to study catalyst performance and life with follow-on testing to be conducted at a later date. The thruster performed as expected. The result of the hot-fire testing are presented in this paper and presentation.
Development of an object-oriented environment for modern mass rapid transit system design and simulation (1995)

International Journal of Engineering Intelligent Systems for Electrical Engineering and Communications
Simultaneous determination of YM‐64227, a phosphodiesterase type 4 inhibitor, and its ﬁve metabolites in dog plasma by high‐performance liquid chromatography with ﬂuorescence detection (2004)

We developed and validated a reversed-phase high-performance liquid chromatographic method with fluorescence detection for the simultaneous determination of YM-64227 [4-cyclohexyl-1-ethyl-7-methylpyrido(2,3-d)pyrimidin-2-(1H)-one], a novel and selective phosphodiesterase type 4 inhibitor, and its fi ve hydroxylated metabolites in dog plasma. The plasma samples were extracted with tert-butyl methyl ether under alkali conditions. The analytes were well separated on a phenyl ethyl column (5 microm, 250 x 4.6 mm i.d.), opreating at 40 degrees C and using an acetonitrile-acetic acid gradient at a fl ow rate of 1.0 mL/min. The fluorescence signal was monitored at an excitation and emission wavelength of 330 and 400 nm, respectively. No interfering peak was observed at the retention time of YM-64227, its metabolites or the internal standard. The validated quantitation range of the method was 0.4-200 ng/mL for all analytes using 0.5 mL of the plasma sample. The recovery of analytes in the extraction process was more than 65.5%. The intra- and inter-assay precision was less than 5.1 and 12.6%, respectively, and the intra- and inter-assay accuracy ranged from -8.1 to 11.8% and -8.0 to 9.9%, respectively. Using this assay, the plasma concentration of YM-64227 and metabolites can be determined after the oral administration of YM-64227 to beagle dogs.
ChemInform Abstract: Photoassisted C‐H Bond Activation with RhCl(CO)(PR3)2 in the Presence of Isocyanides Leading to Catalytic Formation of Aldimines. (1988)

Abstract Cyclohexyl isocyanide (I) is irradiated in benzene (II) or pentane (VI) in the presence of Rh catalysts, yielding the imines (III) or (VII) ‐(IX), the amine (IV), and diphenyl (V).
Chronic retene exposure causes sustained induction of CYP1A activity and protein in rainbow trout (Oncorhynchus mykiss) (1998)

Abstract The removal of persistent chlorinated organic compounds from pulp mill effluents has not eliminated mixed function oxygenase (MFO) induction by these effluents. Therefore, continuous MFO induction downstream of pulp mills may be due to exposure to more labile compounds, such as retene (an alkyl-substituted phenanthrene), which typically cause transient induction after a single brief exposure. Because fish are exposed continuously to pulp mill effluents, we have tested, and rejected, the null hypothesis that continuous exposure of fish to retene does not cause sustained MFO induction. Rainbow trout exposed continuously to retene, a component of some pulp mill effluents and sediments downstream of pulp mills, showed concentration-dependent increases in hepatic ethoxyresorufin-O-deethylase (EROD) activity. The increase in EROD activity was sustained over 32 d of continuous exposure, but it diminished to background levels within 4 d after transfer to clean water. The enzymatic response was confirmed by measuring changes in the content of immunodetectable cytochrome P4501A (CYP1A) protein. These data support a role for labile, nonhalogenated compounds in chronic effects of pulp mill effluents on fish.
In Situ Tissue Engineering of the Bile Duct Using Polypropylene Mesh-Collagen Tubes (2007)

Multiple attempts have been made to replace biliary defects with a variety of materials. Recently, successful biliary reconstruction using the Gore-Tex vascular graft has been reported experimentally and clinically. We designed a new artificial bile duct consisting of collagen sponge and polypropylene mesh. We presently evaluated the feasibility of using this prosthesis as a scaffold for bile duct tissue regeneration in a canine model. Our prosthesis, a sponge made from porcine dermal collagen, is reinforced with a polypropylene mesh cylinder. We used the prosthesis to reconstruct the middle portion of the common bile duct in seven beagle dogs to evaluate its efficacy. While one dog died of biliary stricture 8 months after operation, six survived without problems to scheduled time points for tissue evaluation at 1 to 12 months. All prostheses had become completely incorporated into the host. A confluent epithelial lining was observed within 3 months. In cholangiograms the prosthesis displayed long-term patency in the six dogs and provided satisfactory bile drainage for up to 12 months. Our graft thus shows promise for repair of biliary defects and should lead to development of a new treatment for biliary reconstruction.
Data modeling of time-based media (1994)

Many aspects of time-based media—complex data encoding, compression, “quality factors,” timing—appear problematic from a data modeling standpoint. This paper proposes timed streams as the basic abstraction for modeling time-based media. Several media-independent structuring mechanisms are introduced and a data model is presented which, rather than leaving the interpretation of multimedia data to applications, addresses the complex organization and relationships present in multimedia.
Cucurbitacin Contents in Hemsleya dolichocarpa (1991)

Hemsleya dolichocarpa was studied for its cucurbitacin contents during growing period. A colorimetric method was used to determine the total cucurbitacin levels, and a TLC densitometric assay was employed for estimating dihydrocucurbitacin F and its acetate, two active principles in Hemsleya plants. Cucurbitacin contents rise progressively from May to November; the month of November is thus the most desirable time for harvesting plant materials for medicinal uses. It was noticed that the spoiled plant samples gave an intense color reaction while dihydrocucurbitacin F and its acetate levels were not significantly altered. The accuracy of the assays is discussed.
The wing stent facilitates repeat bile duct cannulation for multiple stent insertion (2010)

The primary disadvantage of conventional plastic biliary stents is their short patency rate [1], as they are prone to biofilm buildup within the central lumen of the stent, resulting in impaired bile flow [2]. The wing stent (ViaDuct; GI Supply, Camp Hill, Pennsylvania, USA) was engineered to overcome this problem ([Fig. 1]).
KRAS and EGFR status as predictive markers of response and time to progression in EGFR wild-type stage IV non-small cell lung cancer (NSCLC) patients treated with EGFR tyrosine-kinase inhibitors. (2013)

e19000 Background: KRAS mutations on codons 12, 13 and 61 result in the constitutive activation of protein, which may render tumor cells independent of epidermal growth factor receptor (EGFR) signalling and thereby resistant to tyrosine-kinase inhibitor (TKI) therapy in NSCLC patients. This study was aimed to evaluate the associations of KRAS and EGFR copy number alteration and mutations with response and time to progression (TTP) in EGFR TKI-treated patients. Methods: 84 samples from NSCLS patients treated with erlotinib or gefitinib were analyzed for KRAS and EGFR mutation status by cobas KRAS and EGFR Mutation Tests (Roche). EGFR copy number was determined by fluorescent in situ hybridization (FISH, Abbott Molecular) and amplification was defined with three or more gene copies in tumor. Results: KRAS mutation was detected in 15 (17.8%) cases, EGFR mutation in 27 (32.1%) and EGFR amplification in 8 (9.5%). Significant differences were detected in response rates for wild-type (0.2) and mutant KRAS (0.0) (p=0.023), for wild-type (0.12) and mutant EGFR (0.39) (p=0.007), and for non-amplified (0.18) and EGFR-amplified (0.71) patients (p=0.005). Additionally, significant benefit from TKI therapy was observed for KRAS wild-type compared with KRAS-mutated patients (median TTP 7 vs. 3 months, p=0.001), for EGFR-mutated compared with wild-type patients (14 vs. 4 months, p=0.004) and for EGFR-amplification in contrast to non-amplified cases (11 vs. 5 months, p=0.001). KRAS and EGFR mutations or EGFR amplification did not correlated with overall survival (18 vs. 19 months, p=0.406; 16 vs. 21 p=0.094; 25 vs. 17 months, p=0.103, respectively). Combined analysis of favourable status of three biomarkers strongly predicted benefit to TKI therapy (median TTP 15 vs. 3 months, p&lt;0.001). Conclusions: Combined analysis ofKRAS mutation, EGFR mutation and EGFR amplification in EGFR TKI-treated NSCLC might provide superior predictive information than single biomarker study in these patients.
Spheno-orbital Meningiomas: A Retrospective Clinical and Radiological Study with Long-Term Follow-Up (2007)

Purpose: To analyze long-term clinical and radiological results with main emphasis on exophthalmos in patients operated on for a spheno-orbital meningioma.
ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity. (1982)

Islet-activating protein (IAP), one of the pertussis toxins, exerted dual actions on crude membrane preparations from rat C6 glioma cells; an Mr = 41,000 membrane protein was ADP-ribosylated while GTP (and GTP-dependent isoproterenol) activation of membrane adenylate cyclase was enhanced when membranes were incubated with IaP. Both actions of IaP were dependent on the incubation time and the concentrations of NAD and IAP, and were inhibited by nicotinamide; the one action was strictly paralleled by the other in magnitude. Tryptic digestion of the Mr = 41,000 protein was markedly influenced by the presence of guanyl-5'-yl beta-gamma-imidodiphosphate or NaF, the specific ligands of the regulatory component of the adenylate cyclase system. No ADP ribosylation occurred in the membranes prepared from intact C6 cells that had been incubated with IAP, suggesting that the IAP substrate had already been ADP-ribosylated by the intracellular NAD during incubation of the intact cells. Cholera toxin catalyzed ADP ribosylation of other proteins with Mr = 45,000 and 48,000/49,000 (doublet). It is concluded that IAP, added to intact cells or isolated membranes, causes unique modification of the receptor-adenylate cyclase coupling mechanism as a result of ADP ribosylation of the Mr = 41,000 protein which is presumably one of the subunits, other than the cholera toxin substrates, of the guanine nucleotide regulatory component of the cyclase system.
Facile Synthesis of 5-Substituted Arabinofuranosyluracil Derivatives (1994)

Abstract Arabinoaminooxazoline reacted readily with α-(bromomethyl)acrylate derivatives to afford the corresponding adduct. Potassium tert-butoxide- or sodium methoxide-catalyzed cyclization of the adduct gave 5-substituted 2,2′-anhydroarabinofuranosyluracil derivatives.
Electrical discharge in an air gap with dielectric-covered electrodes (2002)

Results of numerical simulations of discharge development in an air gap between electrodes covered with solid dielectric are reported. Temporal and spatial variations of gas discharge parameters, dynamics of surface charge accumulation on dielectric barriers and the corresponding behavior of electric field in the gas gap and in the dielectric layers are presented and discussed. Evaluation of calculated data allowed explaining phenomena observed experimentally in the similar electrode system with solid dielectric barriers, leading, in particular, to significant improvement of dielectric strength of the whole system.
THE CATABOLISM OF PROTEIN ANTIGENS IN THE NEWBORN AND MATURING RABBIT (1963)

The rate of degradation, organ deposition, and blood clearance of SBSA, SRSA, and IRSA has been measured in the newborn, 6-, and 30-day-old rabbits. When the animals were injected with a weight-graded dose of the 3 proteins, differences in their catabolism in the newborns were demonstrable as compared to the 6-, and 30-day-old animals. The capacity to degrade the azo compounds was shown to be incompletely developed at birth. At 6 days of age, however, the rabbits catabolized these proteins much at the same rate as the 30-day-old animals. Addition of the benzenesulfonate moiety determined the rate of degradation organ deposition and excretion rather than the carrier protein when the azo compounds were injected. The biosynthetically labeled S(25) rabbit serum albumin (IRSA) was catabolized at a slower rate than the azoproteins in all age groups. Very little difference in the metabolism and organ deposition of the IRSA was shown to exist between the newborn and maturing animals. A dosage schedule, therefore, designed to test the immunological capacity of developing animals may not be valid when calculated upon body weight. The low level of activity of enzyme systems present at birth which degrade anti-genic material may serve as an explanation as to why this period of development is so vulnerable to the induction of tolerance rather than immunity when compared to the adult.
Advancing the science of dynamic airborne nanosized particles using Nano-DIHM (2021)

In situ and real-time characterization of aerosols is vital to several fundamental and applied research domains including atmospheric chemistry, air quality monitoring, or climate change studies. To date, digital holographic microscopy is commonly used to characterize dynamic nanosized particles, but optical traps are required. In this study, a novel integrated digital in-line holographic microscope coupled with a flow tube (Nano-DIHM) is demonstrated to characterize particle phase, shape, morphology, 4D dynamic trajectories, and 3D dimensions of airborne particles ranging from the nanoscale to the microscale. We demonstrate the application of Nano-DIHM for nanosized particles (≤200 nm) in dynamic systems without optical traps. The Nano-DIHM allows observation of moving particles in 3D space and simultaneous measurement of each particle's three dimensions. As a proof of concept, we report the real-time observation of 100 nm and 200 nm particles, i.e. polystyrene latex spheres and the mixture of metal oxide nanoparticles, in air and aqueous/solid/heterogeneous phases in stationary and dynamic modes. Our observations are validated by high-resolution scanning/transmission electron microscopy and aerosol sizers. The complete automation of software (Octopus/Stingray) with Nano-DIHM permits the reconstruction of thousands of holograms within an hour with 62.5 millisecond time resolution for each hologram, allowing to explore the complex physical and chemical processes of aerosols.