gebhart/patrepeval huggingface dataset:
Global stability analysis of self-oscillating mixers (1995)

The harmonic balance technique is applied here to the simulation of self-oscillating mixers and it is combined with a bifurcations analysis in order to predict the evolution of their IF output as a function of input power or frequency. A technique has also been developed to obtain the global stability portrait of these circuits, allowing to determine the limits of their mixing operation. These techniques have been applied to a self-oscillating mixer in X-band, obtaining very good agreement with the experimental results.
Analysis of convolution neural network for transfer learning of sentiment analysis in Indonesian tweets (2018)

Sentiment analysis is an activity to classify public opinion about entities in textual data into positive or negative. One of the automatic methods for sentiment analysis is convolution neural network (CNN). CNN consists of many layers with many parameters that can be adjusted as needed to form a specific architecture. CNN works well in similar domains; however, it gives less accurate in different domains. Therefore, we consider transfer learning which transfers knowledge from a source domain to different but related target domains. In this paper, we examine parameter sensitivity and accuracy of CNN for transfer learning of sentiment analysis in Indonesian tweets. Our simulation shows that the parameters are very sensitive and incremental learning significantly increases the accuracy of transfer learning of the CNN model.
Metagenomic recovery of two distinct comammox Nitrospira from the terrestrial subsurface (2019)

The recently discovered comammox process encompasses both nitrification steps, the aerobic oxidation of ammonia and nitrite, in a single organism. All known comammox bacteria are affiliated with Nitrospira sublineage II and can be grouped into two distinct clades, referred to as A and B, based on ammonia monooxygenase phylogeny. In this study, we report high-quality draft genomes of two novel comammox Nitrospira from the terrestrial subsurface, representing one clade A and one clade B comammox organism. The two metagenome-assembled genomes were compared with other representatives of Nitrospira sublineage II, including both canonical and comammox Nitrospira. Phylogenomic analyses confirmed the affiliation of the two novel Nitrospira with comammox clades A and B respectively. Based on phylogenetic distance and pairwise average nucleotide identity values, both comammox Nitrospira were classified as novel species. Genomic comparison revealed high conservation of key metabolic features in sublineage II Nitrospira, including respiratory complexes I-V and the machineries for nitrite oxidation and carbon fixation via the reductive tricarboxylic acid cycle. In addition, the presence of the enzymatic repertoire for formate and hydrogen oxidation in the Rifle clades A and B comammox genomes, respectively, suggest a broader distribution of these metabolic features than previously anticipated.
Novel 2-alkythio-4-chloro-N-[imino(heteroaryl)methyl]benzenesulfonamide Derivatives: Synthesis, Molecular Structure, Anticancer Activity and Metabolic Stability (2023)

A series of novel 2-alkythio-4-chloro-<i>N</i>-[imino-(heteroaryl)methyl]benzenesulfonamide derivatives, <b>8</b>-<b>24</b>, were synthesized in the reaction of the <i>N</i>-(benzenesulfonyl)cyanamide potassium salts <b>1</b>-<b>7</b> with the appropriate mercaptoheterocycles. All the synthesized compounds were evaluated for their anticancer activity in HeLa, HCT-116 and MCF-7 cell lines. The most promising compounds, <b>11</b>-<b>13</b>, molecular hybrids containing benzenesulfonamide and imidazole moieties, selectively showed a high cytotoxic effect in HeLa cancer cells (IC<sub>50</sub>: 6-7 μM) and exhibited about three times less cytotoxicity against the non-tumor cell line HaCaT cells (IC<sub>50</sub>: 18-20 μM). It was found that the anti-proliferative effects of <b>11</b>, <b>12</b> and <b>13</b> were associated with their ability to induce apoptosis in HeLa cells. The compounds increased the early apoptotic population of cells, elevated the percentage of cells in the sub-G1 phase of the cell cycle and induced apoptosis through caspase activation in HeLa cells. For the most active compounds, susceptibility to undergo first-phase oxidation reactions in human liver microsomes was assessed. The results of the in vitro metabolic stability experiments indicated values of the factor t<sub>½</sub> for <b>11</b>-<b>13</b> in the range of 9.1-20.3 min and suggested the hypothetical oxidation of these compounds to sulfenic and subsequently sulfinic acids as metabolites.
Highly efficient and stable catalyst for peroxynitrite decomposition (2001)

The new cobalt substituted-polyoxometalate K 7 [CoAlW 11 O 39 ]·15H 2 O and the simple CoCl 2 ·6H 2 O salt are efficient catalysts for peroxynitrite decomposition. These compounds also catalyze the oxidation of ascorbic acid and the nitration of phenol by peroxynitrite.Key words: peroxynitrite, polyoxometalates, antioxidant.
On the Cybernetics of Artificial Personality: Correlating with Human Traits (2021)

George and Mary (G&amp;M) is a US patented cybernetics application of two talking heads which uses a repertoire of sentences to generate artificial conversation with no linguistic analysis or parsing. The underlying design assumption of G&amp;M is age dependence: The artificial personality follows Age Trend Classification (ATC) model with four complex dimensions. The idea of adult age dependence contrasts with main currents in academic psychology, which assume a substantially constant personality in adulthood. The Big 5 personality traits are widely used as a psychological personality model, part of their popularity is the free availability of evaluation questionnaires. This work is a correlation study between four ATC and five Big 5 traits, taking into account age dependence, so that correlation is represented graphically as profiles rather than single values of correlation coefficients. The practical consequences of validated artificial personality include customized man-machine interaction to the age and personality of the users and targeted internet marketing.
Development of a Novel In-Vitro Simulator for Elbow Motion (2008)

In-vitro simulation of active joint motion is useful to compare various rehabilitation protocols and surgical procedures. However to date, simulated active elbow flexion has only been achieved in the vertical orientation, in which the gravity load direction is constant. This makes vertical flexion analogous to lifting a weight. Flexion in the varus, valgus and horizontal orientations (of the humerus) are more challenging because gravity load resistance reverses direction part way through flexion, thus requiring more refined muscle control. Furthermore, horizontal flexion generates exceptionally high muscle and joint forces, while varus and valgus flexion challenge the stability of elbow joint articulation.
Agrobacterium tumefaciens-Induced Bacteraemia Does Not Lead to Reporter Gene Expression in Mouse Organs (2008)

Agrobacterium tumefaciens is the main plant biotechnology gene transfer tool with host range which can be extended to non-plant eukaryotic organisms under laboratory conditions. Known medical cases of Agrobacterium species isolation from bloodstream infections necessitate the assessment of biosafety-related risks of A. tumefaciens encounters with mammalian organisms. Here, we studied the survival of A. tumefaciens in bloodstream of mice injected with bacterial cultures. Bacterial titers of 10(8) CFU were detected in the blood of the injected animals up to two weeks after intravenous injection. Agrobacteria carrying Cauliflower mosaic virus (CaMV) 35S promoter-based constructs and isolated from the injected mice retained their capacity to promote green fluorescent protein (GFP) synthesis in Nicotiana benthamiana leaves. To examine whether or not the injected agrobacteria are able to express in mouse organs, we used an intron-containing GFP (GFPi) reporter driven either by a cytomegalovirus (CMV) promoter or by a CaMV 35S promoter. Western and northern blot analyses as well as RT-PCR analysis of liver, spleen and lung of mice injected with A. tumefaciens detected neither GFP protein nor its transcripts. Thus, bacteraemia induced in mice by A. tumefaciens does not lead to detectable levels of genetic transformation of mouse organs.
Power Optimal Non-contiguous Spectrum Access in Multi Front End Radio Enabled Point-to-Point Link (2014)

Non-contiguous spectrum chunks allow wireless links to flexibly access a wide amount of bandwidth. Multi- Channel Multi-Radio (MC-MR) and Non-Contiguous Orthogonal Frequency Division Multiplexing (NC-OFDM) are the two commercially viable strategies to access non-contiguous spectrum chunks. MC-MR accesses multiple non-contiguous chunks by activating multiple front ends which, in turn, increases the circuit power consumption of each of the activated front ends. NC-OFDM accesses non-contiguous spectrum chunks with a single front end by nulling remaining subchannels but increases spectrum span which, in turn, increases the power consumption of ADC and DAC. This work focuses on a point-to-point link where transmitter and receiver have multiple front ends and can employ NC-OFDM technology. We investigate optimal spectrum fragmentation in each front end from a system power (summation of transmit power and circuit power) perspective. We formulate a mixed integer non-linear program (MINLP) to perform power control and scheduling, and minimize system power by providing a greedy algorithm (O(M^3 I)) where M and I denote the number of channels and radio front ends respectively.
Real-time control systems: a tutorial (2004)

The literature about real-time systems presents digital control or computer controlled systems as one of its most important practical application field. However, it is very difficult to find in these textbooks real-time control aspects. It seems to be more natural that these applications should be treated as part of digital control courses. In spite of that, control system literature rarely includes extensively the real-time subject and it does normally not pay attention to real-time aspects beyond algorithms and choice of sampling times. The aim of this paper is to highlight important issues about real-time systems that should be taken into account at the moment to implement digital control.
Electrodeposited Cu2O as Photoelectrodes with Controllable Conductivity Type for Solar Energy Conversion (2015)

Electrodeposition of copper acetate under mild acidic conditions followed by a controlled annealing process allowed the manipulation of the oxygen vacancies in the resultant Cu2O-based electrodes. The conduction type of the Cu2O-based semiconductor was, therefore, tunable, allowing the fabrication of n-type, p-type, and p–n junction photoelectrodes. A transformation of the original n-type conduction to the subsequent p-type nature was observed through the variation of annealing temperature and duration. The observation of anodic and cathodic photocurrents for n-type and p-type thin films confirmed their potential use as photoanodes and photocathodes, respectively, in liquid-junction photoelectrochemical systems. The high carrier densities of the electrodeposited n- and p-type Cu2O were estimated to be 8.9 × 1019 and 1.3 × 1020 cm–3, respectively, using Mott–Schottky analysis. Furthermore, the p–n junction photoelectrodes in a device configuration also exhibited diode behavior in current–voltage measurements, indicating their potential application in solid-state photovoltaic devices.
Hypogonadism and renal failure: An update (2015)

The prevalence of both hypogonadism and renal failure is increasing. Hypogonadism in men with renal failure carries with it significant morbidity, including anemia and premature cardiovascular disease. It remains unclear whether testosterone therapy can affect the morbidity and mortality associated with renal failure. As such, in this review, we sought to evaluate the current literature addressing hypogonadism and testosterone replacement, specifically in men with renal failure. The articles chosen for this review were selected by performing a broad search using Pubmed, Embase and Scopus including the terms hypogonadism and renal failure from 1990 to the present. This review is based on both primary sources as well as review articles. Hypogonadism in renal failure has a multifactorial etiology, including co-morbid conditions such as diabetes, hypertension, old age and obesity. Renal failure can lead to decreased luteinizing hormone production and decreased prolactin clearance that could impair testosterone production. Given the increasing prevalence of hypogonadism and the potential morbidity associated with hypogonadism in men with renal failure, careful evaluation of serum testosterone would be valuable. Testosterone replacement therapy should be considered in men with symptomatic hypogonadism and renal failure, and may ameliorate some of the morbidity associated with renal failure. Patients with all stages of renal disease are at an increased risk of hypogonadism that could be associated with significant morbidity. Testosterone replacement therapy may reduce some of the morbidity of renal failure, although it carries risk.
Iron Contents in Rice Food Derived from the Iron Pot, and In Vitro Study Regarding Heme Oxygenase-1 Activity (2016)

Background: Iron pots have long been used for cooking in several countries. Early studies have shown that the use of such iron pots can increase the iron content of food cooked in them and that this increased iron content has some effect on iron uptake. This study was designed to evaluate the iron content in rice cooked in a traditional iron pot and study the iron uptake by macrophages through heme oxygenase-1 (HO-1).
Some critical remarks on a hierarchy of fault-detecting abilities of test methods [and reply] (1995)

In a recent article by P.G. Frankl and E.J. Weyuker (see ibid., vol.19, no.3, p.962-75, 1993), results are reported that appear to establish a hierarchy of software test methods based on their respective abilities to detect faults. The methods used by Frankl and Weyuker to obtain this hierarchy constitute a new and important addition to their arsenal of tools. These tools were developed specifically to establish simple, useful comparisons of test data generation methods. This is the latest step in an ambitious test method classification program undertaken by the Frankl and Weyuker and their collaborators. The article discusses the method and goes on to present a reply to the critique.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Optimization approaches to nonlinear model predictive control (1991)

With the development of sophisticated methods for nonlinear programming and powerful computer hardware, it now becomes useful and efficient to formulate and solve nonlinear process control problems through on-line optimization methods. This paper explores and reviews control techniques based on repeated solution of nonlinear programming (NLP) problems. Here several advantages present themselves. These include minimization of readily quantifiable objectives, coordinated and accurate handling of process nonlinearities and interactions, and systematic ways of dealing with process constraints. We motivate this NLP-based approach with small nonlinear examples and present a basic algorithm for optimization-based process control. As can be seen this approach is a straightforward extension of popular model-predictive controllers (MPCs) that are used for linear systems. The statement of the basic algorithm raises a number of questions regarding stability and robustness of the method, efficiency of the control calculations, incorporation of feedback into the controller and reliable ways of handling process constraints. Each of these will be treated through analysis and/or modification of the basic algorithm. To highlight and support this discussion, several examples are presented and key results are examined and further developed. 74 refs., 11 figs.
Intradermal Influenza Vaccine Elicits Superior Immunogenicity in Adults Aged ≥60 Years: A Randomized Controlled Phase 3 Trial (2008)

Background: Annual trivalent inactivated vaccines (TIV) provide protection against influenza and its complications for hundreds of millions of individuals. Yet among adults aged ≥60 years, vaccine efficacy is lower than in younger adults. Elderly adults are also the most at risk, with the highest influenza morbidity and mortality. An influenza vaccine, injected using a novel intradermal microinjection system, has been developed with the aim of offering improved protection for this vulnerable population. Methods: A multicenter, randomized controlled phase 3 trial was conducted to assess whether TIV given via ID microinjection induces a superior immune response in adults ≥60 years, compared with an intramuscular (IM) control vaccine (Vaxigrip®). Each vaccine dose contained 15 μg hemagglutinin/strain. Strain-specific hemagglutination inhibition titers were assessed on D0 and 21 using a standard assay. Results: 3701 subjects aged 60–94 years (mean: 70.8 ± 6.8) were enrolled and vaccinated ID (n = 2612) or IM (n = 1089). 54.4% were female. Seroprotection rates were significantly higher in the ID group (p = 0.0003 for H1N1 and B, p < 0.0001 for H3N2) with a difference of 5.5–6.6 percentage for each strain. Mean titer increases after ID vaccination were: H1N1 3.97, H3N2 8.19 and B 3.61, which were 24.5%, 53.1% and 18.8% higher (p < 0.0001) than the corresponding values in the IM group. Seroconversion rates among those with a prevaccination titer <10 were significantly higher with ID: H1N1 64.3% vs 55.6% p = 0.0127, H3N2 80.9% vs 69.3% p = 0.0003 and B 41.3% vs 35.5% p = 0.0282. Conclusion: In a large phase 3 population of adults aged 60–94, the immunogenicity of a new ID influenza vaccine was superior to that of a conventional IM control vaccine. Increased serum antibody responses should provide improved protection against influenza for this vulnerable population. 13th International Congress on Infectious Diseases Abstracts (Oral Presentations)International Journal of Infectious DiseasesVol. 12Preview Full-Text PDF Open Archive
Mechanochemistry for shock wave energy dissipation (2017)

Using a laser-driven flyer-plate apparatus to launch 75 μm thick Al flyers up to 2.8 km/s, we developed a technique for detecting the attenuation of shock waves by mechanically-driven chemical reactions. The attenuating sample was spread on an ultrathin Au mirror deposited onto a glass window having a known Hugoniot. As shock energy exited the sample and passed through the mirror, into the glass, photonic Doppler velocimetry monitored the velocity profile of the ultrathin mirror. Knowing the window Hugoniot, the velocity profile could be quantitatively converted into a shock energy flux or fluence. The flux gave the temporal profile of the shock front, and showed how the shock front was reshaped by passing through the dissipative medium. The fluence, the time-integrated flux, showed how much shock energy was transmitted through the sample. Samples consisted of microgram quantities of carefully engineered organic compounds selected for their potential to undergo negative-volume chemistry. Post mortem analytical methods were used to confirm that shock dissipation was associated with shock-induced chemical reactions.
LASAGNA: A novel algorithm for transcription factor binding site alignment (2013)

We conclude that the LASAGNA algorithm is simple and effective in aligning variable-length binding sites. It has been integrated into a user-friendly webtool for TFBS search and visualization called LASAGNA-Search. The tool currently stores precomputed PSSM models for 189 TFs and 133 TFs built from TFBSs in the TRANSFAC Public database (release 7.0) and the ORegAnno database (08Nov10 dump), respectively. The webtool is available at http://biogrid.engr.uconn.edu/lasagna_search/.
Cardiomyocyte‐Specific Snrk Prevents Inflammation in the Heart (2019)

Background The SNRK (sucrose-nonfermenting-related kinase) enzyme is critical for cardiac function. However, the underlying cause for heart failure observed in <i>Snrk</i> cardiac conditional knockout mouse is unknown. Methods and Results Previously, 6-month adult mice knocked out for <i>Snrk</i> in cardiomyocytes (CMs) displayed left ventricular dysfunction. Here, 4-month adult mice, on angiotensin II (Ang II) infusion, show rapid decline in cardiac systolic function, which leads to heart failure and death in 2 weeks. These mice showed increased expression of nuclear factor κ light chain enhancer of activated B cells (NF-κB), inflammatory signaling proteins, proinflammatory proteins in the heart, and fibrosis. Interestingly, under Ang II infusion, mice knocked out for <i>Snrk</i> in endothelial cells did not show significant systolic or diastolic dysfunction. Although an NF-κB inflammation signaling pathway was increased in <i>Snrk</i> knockout endothelial cells, this did not lead to fibrosis or mortality. In hearts of adult mice knocked out for <i>Snrk</i> in CMs, we also observed NF-κB pathway activation in CMs, and an increased presence of Mac2<sup>+</sup> macrophages was observed in basal and Ang II-infused states. In vitro analysis of <i>Snrk</i> knockdown HL-1 CMs revealed similar upregulation of the NF-κB signaling proteins and proinflammatory proteins that was exacerbated on Ang II treatment. The Ang II-induced NF-κB pathway-mediated proinflammatory effects were mediated in part through protein kinase B or AKT, wherein AKT inhibition restored the proinflammatory signaling protein levels to baseline in <i>Snrk</i> knockdown HL-1 CMs. Conclusions During heart failure, SNRK acts as a cardiomyocyte-specific repressor of cardiac inflammation and fibrosis.
Production of normal young following transfer of mouse embryos obtained by in vitro fertilization between cryopreserved gametes (1993)

Unfertilized oocytes (C57BL/6N and C3H/He) and epididymal spermatozoa (DBA/2N and Jcl:ICR) from mice were frozen separately and stored at -196 degrees C. After thawing, in vitro fertilization was performed using C57BL/6N oocytes and DBA/2N spermatozoa, C57BL/6N oocytes and Jcl:ICR spermatozoa, C3H/He oocytes and DBA/2N spermatozoa, and C3H/He oocytes and Jcl:ICR spermatozoa. Embryos developed to the two-cell stage by incubation in vitro were transferred to the oviducts of female recipients on the first day of pseudopregnancy (day when vaginal plug was confirmed). The rate of development to two-cell embryos in each group was in the 22-45% range. When these two-cell embryos were all transferred to recipients, offspring were produced from 23-35% of the embryos.
Portuguese Narrative Songs (2013)

he present study examines the Cancioneiro (the Portuguese narrative song repertoire) from the angle of its most crucial concerns –the tension between love and death as well as that between love and family or social ethos. The material under consideration covers the important corpus collected by Maria Aliete Galhoz and other researchers. Within the space available here, the author sets out from Galhoz’s (quasi) unique exegetic insight (Romanceiro) into this much neglected genre to explore its tellers’ ethos. Love and family issues are not only rampant in this repertoire, but are also considered across a broad variety of scenarios. Love as archetypal social value unfolds as seduction, rejection, treason, fidelity for life or even beyond. As they are an intimate part of the life of certain communities, narrative songs still appear to offer a valid answer to their interpreters’ tensions, challenges and aspirations.