gebhart/patrepeval huggingface dataset:
A New Design and Application of Bioelastomers for Better Control of Intraocular Pressure in a Glaucoma Drainage Device (2013)

Glaucoma drainage device (GDD) implantation is an effective method of lowering the intraocular pressure (IOP). Commonly used GDDs can be classified into nonvalved and valved. Although a stable IOP is critical, currently available devices often cause extreme IOP fluctuations: nonvalved GDDs suffer from a risk of hypotony (IOP<5 mmHg), whereas valved GDDs have a higher risk ocular hypertensive (IOP>22 mmHg). It is hypothesized that a GDD with a valve designed to open around the time of onset of the hypertensive phase, would minimize IOP fluctuation. Accordingly, a valve fabricated from a biodegradable polymer poly(L-lactide-co-ϵ-caprolactone) (PLC 70/30) is evaluated in vitro and in vivo. The pressure response is compared with its non-degradable counterpart in in vitro studies of IOP. It is also established that in vitro, the biodegradability of the valve is programmed to occur over 12 weeks. In vivo, a steady and low IOP is achieved with the biodegradable valve and the hypertensive phase is significantly attenuated compared with the commercial device. Fibrotic encapsulation of the device is also minimized with the biodegradable valve in vivo.
Do bacteria regenerate phosphorus while decomposing seston? (1999)

The C:P ratio of both seston in suspension and seston collected by sediment traps were systematically higher than the Redfield ratio of 106 : 1 (molar) and decreased significantly with depth in the mesotrophic, phosphorus-limited La Concepción reservoir. An aerobic decomposition experiment of seston at different concentrations by a mixed population of reservoir bacteria was performed in batch cultures to investigate the bacterial role in the changes of the C:P ratio. Dissolved phosphorus was taken up during the bacterial growth phase, while carbon was transformed to CO2 . Therefore, the C:P ratio of the decomposing seston decreased during this stage, and could partially explain the vertical distribution for the C:P ratio in this reservoir. During the death phase of the bacteria, flagellate grazing caused most of the bacterial phosphorus to be released to the medium.
Severe Respiratory Syncytial Virus Bronchiolitis in Infancy and Asthma and Allergy at Age 13 (2004)

We have prospectively studied wheezing disorder and allergy in 47 children hospitalized with respiratory syncytial virus (RSV) bronchiolitis in infancy and 93 matched control subjects. Subjects with at least three episodes of wheezing were defined as recurrent wheezers and as having asthma if the episodes were doctor verified. Here we report the outcome at age 13 years in 46/47 children with RSV and 92/93 control subjects. Wheezing disorder and clinical allergy were estimated using a questionnaire. Skin prick tests were performed and serum IgE antibodies measured. Spirometry was undertaken at rest, after dry air challenge, and after beta2-agonist inhalation. The occurrence of symptoms over the previous 12 months was significantly higher in the RSV group than among the control subjects, 43% versus 8% for asthma/recurrent wheezing and 39% versus 15% for allergic rhinoconjunctivitis. Sensitization to common inhaled allergens was more frequent in the RSV group than in the control subjects, judged by skin prick tests (50% versus 28%; p = 0.022), or by serum IgE antibodies (45% versus 26%; p = 0.038). Compared with the control subjects, the RSV group showed mild airway obstruction both at rest and after bronchodilation, and had slightly more reactive airways. RSV bronchiolitis in infancy severe enough to cause hospitalization is a risk factor for allergic asthma in early adolescence.
PRODUCTION METHODS AND PRODUCT CHARACTERISTICS OF JERKY PRODUCED BY SMALL AND VERY SMALL MEAT PROCESSING BUSINESSES (2010)

ABSTRACT Midwestern meat processors were surveyed to determine whether consensus existed among industry processing practices for jerky production. Seventy‐eight plants were contacted, 37 responded and 33 plants sent 61 samples consisting of whole muscle (56%) or chopped and formed (44%) jerky. Samples had mean water activity, salt (NaCl) and pH of 0.74, 6.85% and 5.85, respectively. Plants used either smokehouses (34) or commercial ovens (3). Nine plants measured wet bulb temperature, and one used a relative humidity instrument. However, 35 plants claimed that they were able to control humidity. Controls included closing dampers, steam injection, direct addition of water, placing a pan of water in the house, or a combination of methods. Plants used sodium nitrite (32), sodium erythorbate (15) and potassium sorbate (5), and vacuum (78%), no vacuum (32%) and gas flush (14%) packaging. Most products were stored at room temperature (38%) or refrigerated (32%); or a combination of methods was used. PRACTICAL APPLICATIONS Because of the high variability of processing times and temperatures, processing environment relative humidity, and methods to control humidity used by small and very small plants, there is a need to educate these processors about jerky processing parameters and the need for routine product analysis. Lack of processing knowledge and equipment capabilities also highlights the need for lethality studies in this area in addition to education on jerky process control and food safety for processors. On the basis of the averages from this study, lethality studies should target A w 0.74 (Food Safety Inspection Service requires an A w of ≤0.85), NaCl 6.85% and pH 5.85. Lethality studies should be conducted with cure for most studies. Marinade pH and length of time held in marinade prior to thermal processing as well as packaging effect and subsequent shelf life on pathogen lethality during storage should be considered. This research information could potentially decrease plants' operating costs while helping ensure food safety and public health protection.
Double-Blind, Randomized Comparison of Systemic Continuous Infusion of 0.25 Versus 0.50 mg/kg/24 h of Alteplase over 3 to 7 Days for Treatment of Deep Venous Thrombosis in Heparinized Patients: Results of the European Thrombolysis with rt-PA in Venous Thrombosis (ETTT) Trial (1992)

Thirty-two patients with acute, proximal-vein thrombosis were treated with heparin and alteplase (0.25 versus 0.5 mg/kg/24 h during 3-7 days) in a randomized, double-blind, multicenter, European (ETTT) trial. The treatment resulted in a decrease of the venographic Marder's score from 18 (6-25) to 13 (2-24) units (median, range) in Group I (0.25 mg/kg/24 h, n = 15, median decrease 3.0, p = 0.32) and from 17.5 (3-33) to 15.5 (0-27) in Group II (0.5 mg/kg/24 h, n = 16, median decrease 4.0, p = 0.23). Comparison of the sequential venograms could be performed in 14 cases of Group I and in 15 cases in Group II. A minority of patients showed substantial partial recanalization of the initially obstructed veins on the control venogram (one in each treatment group) and most of the control venograms showed either thrombus size reductions (5 in Group I, 7 in Group II) or no change or even deterioration (8 in Group I, 7 in Group II). Major bleedings were observed in 7 patients (7/32, 22%), 5 of them occurring in Group II (5/17, 29%). Thus, the results of the ETTT trial show that the used low dosages of alteplase administered intravenously over 3-7 days in heparinized patients cannot be recommended as a treatment for patients with deep venous thrombosis of lower limbs and/or pelvis. Further studies are needed to define a more suitable dosage regimen of alteplase in this indication.
A variance-stabilizing transformation for gene-expressionmicroarray data (2002)

We introduce a transformation that stabilizes the variance of microarray data across the full range of expression. Simulation studies also suggest that this transformation approximately symmetrizes microarray data.
Studies of inelastic molecular collisions using impact parameter methods. II. Exact and high-energy approximate calculations (1975)

Exact quantum mechanical impact parameter methods have recently been extended to include inelastic collisions through the use of an effective Hamiltonian. In this paper the nature of the impact parameter formulation will be explored through specific examples. First we consider the case of a calculation for He–para-He2 where the exact impact parameter amplitudes have been computed as a Neumann series of transition matrix elements obtained from an effective Hamiltonian close coupling calculation. The purpose of this calculation is to provide a standard of functional behavior for comparison with amplitudes computed by approximate methods. Such approximate calculations were performed for Ar–TlF scattering using both exponential and fractional high-energy forms for the amplitudes. The two approximations are compared in detail, and it is found that the cross sections resulting from the exponential approximation show reasonable agreement with other calculations for the system using conventional (noneffective) close coupling and various sudden approximations. Ranges of validity for the approximations are discussed and general characteristics of the impact parameter amplitudes and the related cross section integrands are summarized. Comparison is also made with model system calculations discussed in a previous publication. A general procedure is presented for smoothing the highly oscillatory cross section integrands that commonly arise in exponential impact parameter treatments.
Regulation of hypothalamic preprogrowth hormone-releasing factor messenger ribonucleic acid expression in food-deprived rats: a role for histaminergic neurotransmission. (1993)

To determine the component(s) of dietary protein that regulates GH-releasing factor (GRF) synthesis, we measured hypothalamic prepro-GRF mRNA by solution hybridization/nuclease protection analysis in food-deprived rats refed protein-free diets (PF) supplemented with individual amino acids. Adult male Sprague-Dawley rats were allowed free access to food (Fed), food deprived for 72 h (FD), or FD then refed for 72 h with a normal (NF) diet, a protein-free (PF) diet, or PF diets containing tyrosine, tryptophan (Trp), glutamic acid, or histidine (His). Food-deprived rats displayed the expected 80% reduction in hypothalamic prepro-GRF mRNA. Upon refeeding, levels were normalized in rats refed a normal diet, but not in those refed a PF diet alone or with tyrosine, Trp, or glutamic acid. In contrast, prepro-GRF mRNA was restored to 70% of Fed values by a PF diet with His. Supplementing a PF diet with His was sufficient to maintain hypothalamic prepro-GRF mRNA expression, as 3 days of feeding replete rats with PF diet or PF diet with added Trp resulted in a 50% reduction in prepro-GRF mRNA, whereas levels were reduced 25% by feeding animals a PF diet with His. Groups of rats allowed free access to food were treated for 72 h with two daily injections of 100 mg/kg alpha-fluoremethylhistidine, a specific irreversible inhibitor of histidine decarboxylase, to determine if the effect of His on prepro-GRF mRNA depended on neural conversion to histamine. alpha-Fluoremethylhistidine-treated rats showed a 40% reduction in hypothalamic prepro-GRF mRNA, with no concomitant change in preproneuropeptide-Y or preprosomatostatin. These data indicate that decreased hypothalamic prepro-GRF mRNA in FD rats is due in part to the lack of dietary and provide clear evidence for a role of the histaminergic neural system in the regulation of hypothalamic GRF expression.
The Vertebral Body Depths of the Cervical Spine and Its Relation to Anterior Plate-Screw Fixation (1998)

Study Design. A study was performed to measure the vertebral body depths in different locations from C2 to C7. Objectives. To measure the vertebral body depths in 10 linear dimension from C2 to C7. Summary of Background Data. Anterior plate-screw fixation of the cervical spine has been the common surgical procedure for management of multilevel degenerative disc disease and fracture dislocation. However, injury to the spinal cord during drill or screw placement is the most feared complication of this procedure. It is beneficial for one to have a knowledge of the vertebral body depths in different locations of the vertebral body before anterior cervical plating. Methods. Twenty-seven cervical spines from C2 to C7 were evaluated directly for this study. Anatomic evaluation of the vertebral body included the anteroposterior midline sagittal depth and the anteroposterior parasagittal depth 5 mm lateral to midline on the superior and inferior endplates, as well as on the middle body. Measurements also were made of anteroposterior parasagittal vertebral depth with both medial and lateral inclination of 10 degrees, with respect to the parasagittal plane of the vertebral body. Results. In general, the measurements of male specimens were larger than those of female specimens. Significant differences were noted at 21 measurements over C3 through C7. The mean depths of the superior endplate for all male and female specimens increased consistently from C3 to C7. The mean depths of the inferior endplate varied but generally increased from C2 to C6, then decreased to C7. The mean sagittal and parasagittal middle vertebral body depths were both 14 mm. Conclusions. This information, in conjunction with preoperative computed tomographic evaluation, may be helpful in determining proper screw length during anterior plating of the cervical spine.
Exploring success factors for IT carve out projects (2008)

Carve out projects have recently become an emerging issue in practice and theory given the diversity of strategic foci of companies as well as recent merger and acquisition activities.This paper highlights the relevance of IT in such carve out projects.IT depicts their characteristics and specific features with regard to general IT projects as well as success factors for the management of IT carve outs.Based on a systematic literature review, we conducted 18 exploratory expert interviews with different stakeholders involved in the management of IT carve outs.We show that the perception and acknowledgement of the IT function within the overall carve out project is broadly underestimated.We elaborate on learnings for the successful management of the IT function within a carve out project: the involvement of IT executives in the early phases of contract negotiations; improved IT due diligence processes for a better anticipation of IT costs; early analysis of the target enterprise architecture.Additionally, we identified success factors of managing IT carve out projects.This paper is among the first to shed light into the research field of IT carve out projects including exploratory empirical data and gives recommendations for future research of IT carve outs.
Low-Complexity ZF Detection for Double Space-Frequency Transmit Diversity Based OFDM System in Frequency Selective Fading Channel (2007)

In this paper, we propose an efficient low complexity MIMO detection method for double space-frequency transmit diversity (D-SFTD) based coded OFDM system. The proposed MIMO detector involves three-step filtering process to efficiently de-correlate spatially-multiplexed and space-frequency-coded signals without direct matrix inversion process. As the proposed MIMO detector takes advantage of frequency selectivity, not a favorable channel condition for SFBC system, performance degradation caused by low correlation between two consecutive subcarriers is compensated by assigning weighting factor per subcarrier. From computer simulation results, our scheme in D-SFTD outperforms previously proposed suboptimal MIMO detection methods such as iterative interference cancellation based V-BLAST.
New site‐directed reversible inhibitors of 3‐hydroxy‐3‐methylglutaryl‐CoA reductase (1992)

1. CoA-thioether analogues of 3-hydroxy-3-methylglutaryl-CoA containing an additional methyl group at positions 2, 6(methyl at C3) or 4 of the acyl residue were prepared. To probe for hydrophobic interaction, their inhibitory properties were determined with 3-hydroxy-3-methylglutaryl-CoA reductase purified from baker's yeast. The CoA-thioethers were purely competitive inhibitors whose affinity to the reductase was near to that of the physiological substrate. 2. CoA-sulfoxides derived from the CoA-thioethers displayed affinities to the reductase superior to that of the physiological substrate (Km = 7 microM). Depending on the degree of recognition of diastereomers by the enzyme, the inhibitor constants of the two best inhibitors vary from Ki = 200 nM and Ki = 80 nM (diastereomeric mixtures) to 25 nM and 20 nM, respectively (if only one diastereomer would interact with the enzyme).
A thermal energy storage system for adsorbent low-pressure natural gas storage (1992)

Carbon-based adsorbents were determined to be the best enhanced storage media that would store more natural gas at low pressures than achieved with compression only. Thermal energy storage (TES) was previously demonstrated to be a potentially promising technique to mitigate heat effects associated with low-pressure carbon adsorption systems for natural gas storage. Further investigations were conducted to develop information for the design of an optimized adsorption system that incorporates TES heat management. The selection of appropriate phase-change materials and nucleating agents, encapsulant materials, and corrosion inhibitors for a TES heat management system are discussed and the results of extended thermal cyclic behavior are presented. Engineering analyses and finite element analyses are employed to calculate adsorption rates, heat generation, temperatures, and heat transfer within the adsorbent bed. The size, volume, and arrangement of components for an operational TES system designed to accommodate fast-fill within a defined time limit is presented.
Investigation of Primary Crystallite Sizes in Nanocrystalline ZnS Powders: Comparison of Microwave Assisted with Conventional Synthesis Routes (2008)

ZnS powders with primary crystallite sizes of only a few nanometers were prepared by three different synthesis routes at temperatures below 130 degrees C. The reaction of zinc acetate dihydrate with thioacetamide (TAA) in the presence of pyridine and triphenylphosphite (TPP) was carried out using either conventional heating or microwave heating. The obtained powders exhibit sphalerite structure as determined by X-ray diffraction (XRD). The primary crystallites have diameters between 1 and 7 nm obtained by XRD. Small angle X-ray scattering (SAXS) measurements were analyzed by the model-free inverse Fourier-transformation approach, as well as by a hard sphere-model from which particle size and polydispersity were extracted. The particle sizes by SAXS are in good agreement with the primary crystallite sizes obtained by XRD. It has been found that an increasing amount of sulfur and/or using microwave heating increases crystallite sizes. The presence of TPP decreases the particle sizes but no significant influence on the TPP concentration was observed. In the alternative third preparation route, hexamethyldisilathiane (HMDST) was used as precipitation reagent at ambient temperature, which leads to the smallest crystallite sizes of only 1 nm together with low polydispersities. Scanning electron microscopy, dynamic light scattering and UV-vis spectroscopy showed that all three synthesis routes lead to ZnS powders with aggregate sizes between 650 and 1200 nm. Both of the TAA-precipitation routes lead to spherical agglomerates which consist of spherical substructures, whereas the HMDST agglomerates are assembled from elongated objects.
Common polymorphisms in the glyoxalase-1 gene and their association with pro-thrombotic factors (2004)

Advanced glycation endproducts (AGEs) form at an accelerated rate in diabetes and contribute to the development of macrovascular disease. Their precursors are detoxified by the glyoxalase system. Perturbations of the glyoxalase-1 gene may alter AGEs' interactions and affect pro-thrombotic factors. We screened the glyoxalase-1 gene for mutations and measured pro-thrombotic markers in 537 subjects from 89 healthy probands. Common single nucleotide polymorphisms (SNPs) were identified at positions -7 (C to T) and 20203 (C to A) from the translation start site. These SNPs were in Hardy-Weinberg equilibrium (CC=105, CA=266, AA=148; p>0.05; CC=126, CT=279, TT=114; p>0.05, respectively) and in linkage disequilibrium (D=27%, p<0.01), with mutant allele frequencies of 48% and 52% respectively. A significant association was found between SNPs at position 20203 and PAI-1 antigen concentrations and -7 and factor XIII A2B2 complex (p=0.001 and p=0.042). After Bonferroni correction a significant association remained between the SNP at 20203 and PAI-1 concentrations (p=0.005), and after adjustment for pedigree the association accounted for 1.3% of its heritability (p=0.04). No significant associations were found for SNP -7 T to C and factor VII activity, tPa concentrations, fibrinogen concentrations or factor XIII concentrations and SNP 20203 C to A and factor VII concentrations, PAI-1 concentrations, tPa concentrations or fibrinogen concentrations. Common variants in the glyoxalase-1 gene are associated with some pro-thrombotic factors, account for part of their heritability in healthy pedigrees and may alter susceptibility to macrovascular complications.
Lactoseries carbohydrates specify subsets of dorsal root ganglion neurons projecting to the superficial dorsal horn of rat spinal cord (1985)

Cell surface carbohydrates are thought to play important roles in the development and differentiation of mammalian cells. In previous studies we have found that one population of dorsal root ganglion (DRG) neurons is specified by the expression of complex globoseries oligosaccharides (Dodd, J., D. Solter, and T. M. Jessell (1984) Nature 311: 469-472; Jessell, T. M., and J. Dodd (1985) Philos. Trans. R. Soc. Lond. (Biol.) 308: 271-281). We now report that monoclonal antibodies (MAbs) directed against backbone structures of lactoseries oligosaccharides define antigens present in the cytoplasm of a second, anatomically and functionally distinct subset of DRG neurons. Lactoseries carbohydrate structures identified by MAb A5 are restricted to small- and intermediate-diameter DRG neurons with central projections in the superficial dorsal horn of the rat spinal cord. The distribution of labeled terminals suggests that many of the DRG neurons that express lactoseries carbohydrates are likely to convey nociceptive information. More complex galactose- and fucose-substituted lactoseries structures recognized by MAbs LD2, KH10, TC6, TD10, LA4, and anti-Lewis a are segregated on subsets of DRG neurons that differ in their expression of substance P, somatostatin, and fluoride-resistant acid phosphatase and in their laminar termination in the superficial dorsal horn. The majority of lactoseries carbohydrate antigens identified in the cytoplasm of DRG neurons are also expressed on the surface of subsets of DRG neurons in culture. These studies establish that structurally defined carbohydrate differentiation antigens specify the majority of primary sensory neurons with cutaneous receptive fields. Moreover, lactoseries carbohydrate structures similar or identical to those expressed on neonatal DRG neurons in culture have been implicated in cell-cell interactions at early stages of preimplantation embryonic development. Our observations suggest strategies for testing the hypothesis that carbohydrates present on the surface of subsets of DRG neurons play a role in cell interactions that contribute to the laminar organization of sensory afferents in the developing spinal cord.