gebhart/patrepeval huggingface dataset:
[New methods of managing massive upper gastrointestinal bleedings (author's transl)]. (1977)

A four year experience in the management of 585 patients with massive upper gastrointestinal tract bleeding (U. G. I. B.)has been reviewed. The effect of routine fiberoptic gastroscopy, selective angiography, and selective pitressin arterial infusion has been analyzed as it effects the more accurate diagnosis and better non-operative therapy of these dangerously ill patients. Duodenal and gastric ulcer, which comprise one-half of such patients, are best treated by early operation. Mallory-Weiss-syndrome is more frequent than previously appreciated. Pitressin infusion is worthy of trial in diffuse gastritis, varicose- and stress ulcer bleeding. Stress bleeding is usually one manifestation of multiple organ failure due to bacterial sepsis.
Optical study on a phase transition of fresnoiteBa2Si2TiO8 (2001)

Fresnoite ${\mathrm{Ba}}_{2}{\mathrm{Si}}_{2}{\mathrm{TiO}}_{8}$ is a ferroelectric with promising piezoelectric uses that exhibits unusual pyroelectric, elastic, and other property anomalies close to 433 K. X-ray diffraction analyses at 297 and 573 K by Markgraf et al. determined the space group to be $P4\mathrm{bm}$ at both temperatures and appeared to exclude the possibility of these anomalies being caused by a structural phase transition; a convincing alternative interpretation of the origin of these anomalies has not yet been reported. The high accuracy universal polarimeter (HAUP) method offered an alternative investigative approach. A primary difficulty in the present study was ensuring that the illuminated volume of the sample crystal was single and without domain texture. After having solved this problem, the method has established the point group of fresnoite as $4mm$ above 433 K, and as optically active below it. The single gyration tensor component ${g}_{12}$ appears abruptly but continuously on cooling below this temperature and increases with decreasing temperature, reaching $5.8\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}6}$ at 360 K. Thus fresnoite is found to undergo a structural phase transition of second order from a $4mm$ phase to an optically active nonenantiomorphic point group. Combining the change of optical activity with that of the birefringence leads us to the conclusion that the point group below 433 K is $\mathrm{mm}2.$ The present study illustrates the unique and deep insight the HAUP method can provide into condensed-matter phase transitions.
Cocrystal and Salt Forms of Furosemide: Solubility and Diffusion Variations (2016)

Multicomponent solid forms of the BCS class IV drug furosemide (FSM) were obtained upon liquid assisted grinding with coformers anthranilamide (ANT), 4-toluamide (TOL), 2-picolinamide (PCM), piperazine (PPZ), 2,3,5,6-tetramethylpyrazine (TMPZ), pyrazine (PYZ), 2-picolinic acid (PIC), isoniazid (INZ), and theophylline (THP), and identified with powder X-ray diffraction. Solid forms FSM–TMPZ (2:1), FSM–ANT (1:1), FSM–PPZ (1:1), and FSM–TOL ethanol solvate (1:1:1) were further characterized with single crystal X-ray diffraction and differential scanning calorimetry; a sesquihydrate structure for FSM–PCM (1:1:1.5) was additionally confirmed with thermogravimetric analysis. The thermodynamically stable form I of FSM contains O–H···O acid···acid and N–H···O sulfonamide dimer synthons and chains. These synthons are modified in the cocrystals/salts sometimes leading to changes in physicochemical properties. The FSM–PPZ (1:1) salt converted to a thermodynamically more stable form FSM–PPZ (2:1) within 1 h. The apparent solubility of FSM–PPZ (1:1) salt is ∼3 times higher than the equilibrium solubility of the thermodynamically stable FSM–PPZ (2:1) salt. The solubilities of FSM–TMPZ and FSM–ANT are comparable to FSM, and this could be linked to coformer solubility. The metastable FSM–PCM sesquihydrate exhibited unusually high FSM concentration in solution as a function of time and as monitored in a slurry experiment. This prolonged presence of FSM in solution is rationalized by a synthon-extended-spring-and-parachute model. Our rationale starts with Nangia’s explanation of the apparently high solubility of pharmaceutical cocrystals based on the simple spring-and-parachute model of Guzman et al. and later detailed by Brouwers et al. We go on to suggest that certain heteromolecular aggregates might well persist in soluble amorphous forms leading to a higher persistence of the drug in solution. Cocrystals/salts with higher solubility show higher values of initial diffusion/flux. A few bases when used as coformers render stable salt/cocrystals that resulted in low solubility/diffusion. In the new solid forms of FSM studied here, solubility and flux are seen to go hand in hand—an observation of import in drug absorption.
Learning to sequence movement primitives from demonstrations (2014)

We present an approach for learning sequential robot skills through kinesthetic teaching. The demonstrations are represented by a sequence graph. Finding the transitions between consecutive basic movements is treated as classification problem where both Support Vector Machines and Gaussian Mixture Models are evaluated as classifiers. We show how the observed primitive order of all demonstrations can help to improve the movement reproduction by restricting the classification outcome to the currently executed primitive and its possible successors in the graph. The approach is validated with an experiment in which a 7-DOF Barrett WAM robot learns to unscrew a light bulb.
Antibiotic Treatment Prior to Injury Abrogates the Detrimental Effects of LPS in STR/ort Mice Susceptible to Osteoarthritis Development (2023)

Post traumatic osteoarthritis (PTOA) is a form of secondary osteoarthritis (OA) that develops in ~50% of cases of severe articular joint injuries and leads to chronic and progressive degradation of articular cartilage and other joint tissues. PTOA progression can be exacerbated by repeated injury and systemic inflammation. Few studies have examined approaches for blunting or slowing down PTOA progression with emphasis on systemic inflammation; most arthritis studies focused on the immune system have been in the context of rheumatoid arthritis. To examine how the gut microbiome affects systemic inflammation during PTOA development, we used a chronic antibiotic treatment regimen starting at weaning for 6 weeks before anterior cruciate ligament (ACL) rupture in <i>STR/ort</i> mice combined with lipopolysaccharide (LPS)-induced systemic inflammation. <i>STR/ort</i> mice develop spontaneous OA as well as a more severe PTOA phenotype than <i>C57Bl/6J</i> mice. By 6 weeks post injury, histological examination showed a more robust cartilage staining in the antibiotic-treated (AB) <i>STR/ort</i> mice than in the untreated <i>STR/ort</i> controls. Furthermore, we also examined the effects of AB treatment on systemic inflammation and found that the effects of LPS administration before injury are also blunted by AB treatment in <i>STR/ort</i> mice. The AB- or AB+LPS-treated <i>STR/ort</i> injured joints more closely resembled the <i>C57Bl/6J</i> VEH OA phenotypes than the vehicle- or LPS-treated <i>STR/ort</i>, suggesting that antibiotic treatment has the potential to slow disease progression and should be further explored therapeutically as prophylactic post injury. © 2023 The Authors. <i>JBMR Plus</i> published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Supplementary Figure 2 from DDX31 Regulates the p53-HDM2 Pathway and rRNA Gene Transcription through Its Interaction with NPM1 in Renal Cell Carcinomas (2023)

&lt;p&gt;PDF file - 1.5MB, (A) Effects of siRNA-mediated NPM1 knockdown on DDX31 localization in the RCC cell line, Caki-1. NPM1 knockdown did not affect DDX31 nucleolar localization. (B) Effects of DDX31 knockdown on Nucleolin localization. Nucleolin localization was not affected by the presence or the absence of DDX31. Scale bar shows 50 mum&lt;/p&gt;
The Impact of CEO/CFO Outside Directorships on Auditor Selection and Audit Quality (2020)

We examine whether outside directorships of chief executive officer/chief financial officer (CEO/CFO) and resulting network ties to auditors affect auditor selection decisions and subsequent audit quality. The network ties arise when the CEO/CFO of a firm (home firm) serves as an outside director of another firm that hires an auditor (connected auditor). Using a sample of firms that switch auditors in the post-Sarbanes-Oxley Act period, we find that home firms are more likely to appoint connected auditors. We also find that home firms hiring connected auditors experience a significant decline in subsequent audit quality, compared to those hiring non-connected auditors. Specifically, the increases in the likelihood of misstatements, the magnitude of absolute discretionary accruals, and the propensity to meet or beat earnings benchmarks after home firms appoint connected auditors are significantly greater, compared to those for other firms switching to non-connected auditors. We further find that the decline in audit quality is more pronounced when the network is established at the local office level.
A histometric analysis of chronically rejected human liver allografts: Insights into the mechanisms of bile duct loss: Direct immunologic and ischemic factors (1989)

Conspicuous pathologic features of chronic liver allograft rejection include bile duct loss and chronic obliterative arteriopathy. A quantitative histometric analysis was performed to document the extent of bile duct loss, the size of the "vanished" ducts and the extent of chronic obliterative arteriopathy and to determine whether there was any relationship between chronic obliterative arteriopathy and bile duct loss. All failed liver allograft specimens with chronic rejection were reviewed and categorized according to the degree of chronic obliterative arteriopathy, assessed by the degree of luminal narrowing of hilar hepatic artery branches. Histometric analysis of the grafts revealed: (i) there was a loss of small portal arterioles (less than 35 microns); (ii) bile ducts which should accompany arteries less than 35, 35 to 54 or 55 to 74 microns in diameter were missing, with the greatest decrease occurring among the smallest ducts; (iii) bile duct loss was seen in the absence of significant large vessel chronic obliterative arteriopathy, and (iv) the severity of arteriole and bile duct loss, as well as the size of the vanished ducts, was directly proportional to the degree of chronic obliterative arteriopathy. Furthermore, the size of the "vanished" bile ducts in liver allografts appeared to differ from the size of ducts destroyed in primary biliary cirrhosis. These studies offer indirect, but suggestive proof that two mechanisms are operative in the bile duct loss seen in chronic rejection: direct lymphocytotoxicity and ischemic damage.
Nucleation and epitaxial growth of Ge nanoislands on Si surface prepatterned by ion irradiation (2013)

Experimental study of Ge nanoislands growth on groove-patterned Si(001) substrate formed by ion-beam-assisted nanoimprint lithography is carried out. Prepatterning procedure includes ion irradiation of Si substrate through imprinted resist mask and subsequent selective etching of irradiated Si domains. It is shown that temperature during ion irradiation affects the location of subsequently grown Ge nanoislands. The effect is interpreted in terms of additional surface tensile strain formed inside grooves by residual irradiation-induced defects. The effect is stronger for cold irradiated samples due to higher density of residual defects.
Emission properties of an organic light-emitting diode patterned by a photoinduced autostructuration process (2005)

The photoluminescence properties of a periodically structured organic light-emitting diode are presented. Patterning is achieved using an original single-step autostructuration technique based on photoinduced effects in azo-polymer films. We show that single beam laser irradiation can lead to the induction of regular two-dimensional surface relief gratings. The waveguide properties of these microstructures as well as their effect on the emission properties of a light-emitting material are studied. We demonstrate a new straightforward technique to improve external light emission efficiency by outcoupling part of the light that was initially guided into the different diode layers.
MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations. (1993)

T-cell lymphoproliferative diseases are often associated with recurrent chromosomal translocations involving T cell receptor genes (TCR) and genes that are thought to play a role in the pathogenesis of these diseases. Whereas numerous such genes have already been identified in acute T cell leukemias, no candidate gene has yet been identified to play a role in the heterogeneous group of T cell proliferations with a mature phenotype. We here report the molecular cloning of two examples of the rare but recurrent t(X;14) translocation. The first translocation was associated with a benign clonal proliferation in an ataxia telangiectasia patient and the second with a T cell prolymphocytic leukemia. Both translocations implicated the TCR alpha/delta locus and a common breakpoint region on chromosome Xq28. A previously unidentified gene, abnormally transcribed in both T cell proliferations, was characterized in the immediate proximity of the breakpoints. This Xq28 gene has no homology with known sequences, uses a complex alternative splicing pattern and demonstrates two short open reading frames. This gene, named MTCP-1 (Mature T Cell Proliferation-1) is the first candidate gene potentially involved in the leukemogenic process of mature T cell proliferations.
Pharmacokinetics of concomitantly administered foscarnet and zidovudine for treatment of human immunodeficiency virus infection (AIDS Clinical Trials Group protocol 053). (2020)

Foscarnet and zidovudine (ZDV) pharmacokinetic parameters were not altered in five patients receiving 14 days of concomitant therapy. Foscarnet clearance in plasma averaged (+/- standard deviation) 0.16 +/- 0.03 and 0.13 +/- 0.05 liter/h/kg of body weight in the absence and presence of ZDV. ZDV parameters were also not significantly altered, with a mean (+/- standard deviation) oral clearance of 2.7 +/- 1.0 and 2.6 +/- 0.8 liter/h/kg for the 2 study days, respectively.
Exercise Promotes Enhanced Gut Microbial Diversity Compared to Sedentary Counterparts (2014)

1Gotthardt, J.D., 2Noji, M., 3Kerkhof, L.J., 3McGuiness, L., 4Häggblom, M.M., 2Campbell, SC, 1Department of Nutritional Sciences, 2Department of Exercise Science and Sports Studies; 3Institute of Marine and Coastal Sciences; Department of Biochemistry and Microbiology Rutgers, The State University of New Jersey, New Brunswick, NJ 08901 Background: Diet-induced obesity (DIO) has been shown to shift the balance of species present in the gut microbiome from predominantly Bacteroides to Firmicutes. Subsequent studies have shown the other factors can alter gut microbial ecology, e.g. calorie restriction and environmental toxin exposure. Purpose: Our focus is exercise and since exercise contributes to both caloric expenditure and nutrient partitioning, we hypothesized that exercise may also alter gut microbial ecology. Our previous work showed individual clusters for exercised mice, regardless of diet, with 40% variation from sedentary lean and obese clusters as indicated by Sorenson’s Index. Methods: To follow-up these results and assess changes in species we used thirty-six (n=9/group) male C57 mice who were weighed and randomly assigned to one of 4 groups: 1-) lean-sedentary (10% fat diet, Research Diets); 2-) DIO- sedentary (45% fat, Research Diets); 3-) lean-exercise; and 4-) DIO-exercise for 12 weeks. Mice had ad libitum access to food and water. Exercise mice had free access to a running wheel in their cages. Food intake was monitored every other day, body weights once per week and body composition was taken prior to sacrifice. Upon sacrifice feces was obtained from the distal colon and were prepared for cloning and sequencing of genetic material. Results: Results indicated that DIO-exercise mice presented with a lean phenotype compared to their sedentary counterparts, as indicated by lower body weight and fat mass. Sequencing of the genetic material results in identification of greater number and variation of species in samples from exercised mice supporting our hypothesis. Sequencing, however, lead to only the identification of species in the phylum Firmicutes, potentially due to cloning bias. Conclusions: Ongoing work, aims at cultivation of predominant species to understand their impact on systemic metabolism and our recent grant will allow for sample deep sequencing which, will provide a greater distinction between treatment cohorts.
MARVLE: a VLSI chip for data compression using tree-based codes (1993)

Describes the architecture and design of a CMOS VLSI chip for data compression and decompression using tree-based codes. The chip, called MARVLE, implements a memory-based architecture for variable length encoding and decoding based on tree-based codes. The architecture is based on an efficient scheme of mapping the tree representing any binary code onto a memory device. A prototype 2-mm CMOS VLSI chip has been designed, verified, and fabricated by the MOSIS facility. The chip has a 512*12 static RAM with an access time of 4 ns and logic circuitry for compression as well as decompression. The chip occupies a silicon area of 6.8 mm*6.9 mm and consists of 49695 transistors. The prototype chip yields a compression rate of 95.2 Mb/s and a decompression rate of 60.6 Mb/s with a clock rate of 83.3 MHz. The VLSI hardware can be used to implement the JPEG baseline compression scheme.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The management system with emotional virtual human based on smart home (2012)

Affective virtual human is considered to one of the hotspots in the field of virtual human-computer interaction. First, the software platform of the management system has been designed, and the virtual human emotional model has been analyzed. Then, management functions have been carried out or simulated by many technologies. For example, face recognition, speech emotion interactions, text emotion recognition, eye tracking and other technologies. And the management system with emotional virtual human applied on smart home can construct a harmonious living environment, and improve user satisfaction and comfort. Finally, the improvements of the management system are described, to enable better application of human-computer interaction in the harmonious environment.
Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities (2016)

Calcium phosphate system has been used widely in in vitro gene delivery for almost four decades. Excellent biocompatibility and simple application have motivated the researchers to always consider this system in their transfection experiments. However, there was a major drawback regarding the low transfection efficiency of calcium phosphate. Hence, there have been many efforts in order to increase the gene delivery potential of this system. In this paper, the application of calcium phosphate in gene delivery is introduced. Moreover, the recent progresses in the application of calcium phosphate in the delivery of (oligo)nucleotides and different approaches to improve the properties of this system are reviewed.
Women's Fantasies and Feminist Utopias (1977)

Authors of feminist utopian fiction usually begin by showing how women are profoundly alienated and limited by patriarchal society; they then go on to acquaint the reader with an alternative society in which women could feel at home and manifest their potential.1 The works considered here are superficially quite different, yet the utopian societies they create are surprisingly similar. Mary Bradley Lane's Mizarza: A Prophecy,2 and Charlotte Perkins Gilman's Herland,3 grow out of the nineteenth-century women's movement. Marge Piercy's Woman on the Edge of Time,4 and Joanna Russ's The Female Man,5 arise from the contemporary feminist movement. Piercy's work and Ursula Le Guin's The Dispossessed,6 focus on the details of utopian social organization and mores; Dorothy Bryant's The Kin of Ata Are Waiting for You,7 James Tiptree, Jr.'s Houston, Do You Read? 8 and Mary Staton's From the Legend of Biel,9 are more interested in defining an alternative feminist consciousness. This essay will focus on the surprisingly numerous areas of consensus among such seemingly divergent works. To the degree that feminist utopias are critiques of patriarchal society, they tend to emphasize the forces which most directly oppress women. One major concern is the low status and pay for woman's work. In no feminist utopia is there any difference in income according to the kind of work done, although there is some difference in status. In Mizarza, a cook has the highest status; in Herland, a schoolteacher. Another recurring concern of the patriarchy is illegitimacy. In feminist utopias, children are never illegitimate, because they all have mothers. They are not, however, seen as their mother's property, and they do not carry their names. Names are characteristically indicative of individual,
ChemInform Abstract: Studies on the Chemistry of Thienoanellated O,N‐ and S,N‐Containing Heterocycles. Part 5. An Access to the Thieno(2,3‐b) (1,4)oxazine Ring System. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Activated carbon based technology for the control of mercury emission from coal-fired power plants (1999)

S.411-418
Fish oils in the care of coronary heart disease patients: a meta‐analysis of randomized controlled trials (2004)

What is the place of fish oils in the care of coronary heart disease (CHD) patients? As several clinical trials have already addressed this question without giving definitive answers, we did a meta-analysis of trials regarding the efficacy of omega-3 fatty acids in preventing cardiovascular mortality and morbidity. We searched the MEDLINE (1966-2003), EMBASE databases, proceedings abstracts and references of reviewed articles. Randomized controlled trials (RCTs) of the efficacy of omega-3 fatty acids among adults with recent or acute myocardial infarction (MI), or angina were selected. Two reviewers abstracted data independently. Five relevant outcomes, mortality from all causes, fatal and non-fatal MI, non-fatal stroke and angina, were measured. Data were synthesized using a fixed effect model. Ten RCTs with 14,727 patients were included. No significant heterogeneity was detected. Daily intake of omega-3 fatty acids for a mean duration of 37 months decreased all causes of mortality by 16% (relative risk 0.84, 95% confidence interval [0.76; 0.94]) and the incidence of death due to MI by 24% (0.76, [0.66; 0.88]). No significant effect was found for the other outcomes. Because of the suboptimal quality of the studies included into the meta-analysis and the absence of data in patients receiving statins, these results do not justify adding fish oils systematically to the heavy pharmaceutical assortment already recommended in CHD patients.