gebhart/patrepeval huggingface dataset:
New machine for automated solid phase peptide synthesis (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew machine for automated solid phase peptide synthesisVictor J. Hruby, Leon E. Barstow, and Theo. LinharrtCite this: Anal. Chem. 1972, 44, 2, 343–350Publication Date (Print):February 1, 1972Publication History Published online1 May 2002Published inissue 1 February 1972https://pubs.acs.org/doi/10.1021/ac60310a004https://doi.org/10.1021/ac60310a004research-articleACS PublicationsRequest reuse permissionsArticle Views155Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Avaliação estatística do efeito de cargas híbridas na absorção eletromagnética de compósitos de PDMS utilizando o método Simplex Centroid Axial (2022)

Anais da 2ª Conferência Brasileira de Planejamento Experimental e Análise de Dados: ConBraPA 2022 (978-85-5722-443-8) - Avaliação Estatística Do Efeito De Cargas Híbridas Na Absorção Eletromagnética De Compósitos De Pdms Utilizando O Método Simplex Centroid Axial
Advanced materials and design for low temperature SOFCs (2023)

Embodiments of the invention are directed to SOFC with a multilayer structure comprising a porous ceramic cathode, optionally a cathodic triple phase boundary layer, a bilayer electrolyte comprising a cerium oxide comprising layer and a bismuth oxide comprising layer, an anion functional layer, and a porous ceramic anode with electrical interconnects, wherein the SOFC displays a very high power density at temperatures below 700.degree. C. with hydrogen or hydrocarbon fuels. The low temperature conversion of chemical energy to electrical energy allows the fabrication of the fuel cells using stainless steel or other metal alloys rather than ceramic conductive oxides as the interconnects.
Evolution of Chemical Composition, Morphology, and Photovoltaic Efficiency of CH3NH3PbI3 Perovskite under Ambient Conditions (2015)

© 2015 American Chemical Society. The surface composition and morphology of CH3NH3PbI3 perovskite films stored for several days under ambient conditions were investigated by X-ray photoelectron spectroscopy, scanning electron microscopy, and X-ray diffraction techniques. Chemical analysis revealed the loss of CH3NH3 + and I- species from CH3NH3PbI3 and its subsequent decomposition into lead carbonate, lead hydroxide, and lead oxide. After long-term storage under ambient conditions, morphological analysis revealed the transformation of randomly distributed defects and cracks, initially present in the densely packed crystalline structure, into relatively small grains. In contrast to PbI2 powder, CH3NH3PbI3 exhibited a different degradation trend under ambient conditions. Therefore, we propose a plausible CH3NH3PbI3 decomposition pathway that explains the changes in the chemical composition of CH3NH3PbI3 under ambient conditions. In addition, films stored under such conditions were incorporated into photovoltaic cells, and their performances were examined. The chemical changes in the decomposed films were found to cause a significant decrease in the photovoltaic efficiency of CH3NH3PbI3.
Free-Space Quantum Key Distribution using Multilevel Encoding via Transverse Field Modulation: Preprint (2009)

Abstract : Transverse modulation of the complex optical field defines sets of orthogonal states for multilevel quantum key distribution. Principles of holography are evaluated as a means of generating and sorting the single photon states.
Transurethral Microwave Thermotherapy for Management of Benign Prostatic Hyperplasia: Results of the United States Prostatron Cooperative Study (1993)

The primary objective of the study was to determine the safety and efficacy of transurethral microwave thermotherapy for the treatment of symptomatic benign prostatic hyperplasia. From March to August 1991, 150 patients were entered into a multi-site study and treated with transurethral microwave thermotherapy under a Food and Drug Administration approved protocol. Only patients with symmetrical trilobar or bilobar prostatic hypertrophy, peak flow rate of less than 15 cc per second (on 2 voided volumes of 150 cc or greater) and a total Madsen symptom score of more than 8 were treated. Transurethral microwave thermotherapy was performed with a 20F catheter and 1,296 MHz. microwave antenna for 60 minutes. The mean power achieved for this single session was 32.1 watts, with a mean power at maximum urethral temperature of 41.1 watts. Mean urethral temperature was 44.3C and the mean rectal temperature was 42.2C. The rectal and urethral temperatures were continuously monitored. Mean peak urinary flow rates, Madsen symptom score, post-void residual volume and improvement in motivating symptom to seek treatment were measured at 6 weeks, and 3, 6 and 12 months. Mean peak urinary flow rates improved 33% at 12 months (p < 0.0001). Overall, the mean Madsen symptom score improved 61% (p < 0.0001). The obstructive score and the irritative score improved 67% and 43%, respectively. Of 17 patients 12 (71%) reported improvement in weak stream when that was the motivating symptom to seek treatment. Of 28 men 18 (64%) reported improvement in nocturia, while 11 of 30 (37%) reported improvement in daytime frequency and 12 of 17 (71%) reported improvement in urgency. There was no statistically significant difference in post-void residual volume at 12 months from baseline. The treatment was well tolerated by all patients, and side effects were considered mild and transitory. Our study demonstrates the safety, effectiveness, patient tolerability and durability of transurethral microwave thermotherapy.
Precordial electrocardiographic mapping. A technique to assess the efficacy of interventions designed to limit infarct size. (1978)

THE QUANTITY OF MYOCARDIUM which becomes necrotic following coronary occlusion has been shown to influence both the acute and long-term conse- quences of myocardial infarction.1 2 Fortunately, ex- periments now indicate that the size of a myocardial infarct is not irrevocably determined immediately following a cor- onary occlusion, but can be altered substantially by a number of interventions.3-1-However, the clinical assess- ment of interventions designed to protect ischemic myocar- dium has posed considerable difficulty. Precordial electro- cardiographic mapping, including analysis of both the ST segment and the QRS complex, which has been developed over the past several years, is now being used in studies on patients with acute myocardial infarction. In this review evidence will be presented which indicates that electrocar- diographic mapping, when employed properly and with ap- propriate awareness of its limitations, can yield valid results and indicate whether or not an intervention modifies either the severity of ischemia itself or the eventual size of an in- farction.
A novel 53 kDa protein complexed with P210bcr-abl in human chronic myelogenous leukemia cells. (1988)

Leukemic cells from patients with Philadelphia chromosome (Ph1)-positive chronic myelogenous leukemia (CML) contain a 210 kDa protein (P210bcr-abl) with a protein tyrosine kinase activity that is a product of fused bcr and abl genes. We have prepared two monoclonal anti-peptide antibodies, one from each gene product, and have affinity purified each. Incubation of anti-abl (c-abl 51-64) immunoprecipitates of K562 cells with [gamma-32P]ATP in protein kinase assays resulted in the labeling of P210bcr-abl and a 53 kDa (ph-P53) protein. Increasing concentrations of antibody detected similar ratios of P210bcr-abl: ph-P53, suggesting the presence of a complex between the proteins. Several different anti-abl and anti-bcr antibodies detected the ph-P53/P210 complex. Sodium dodecyl sulfate (SDS) treatment without 2-mercaptoethanol eluted P210bcr-abl and ph-P53 from the monoclonal antibody in the form of complexes which migrated on 6% SDS-polyacrylamide gels and had apparent molecular weights of 275,000 and more than 500,000. Both complexes yielded ph-P53 and P210bcr-abl upon treatment with SDS-mercaptoethanol. Studies involving glycerol gradient centrifugation also detected complexes of P210bcr-abl and ph-P53. Our results indicate that ph-P53 is not a degraded product of P210bcr-abl, does not share antigenic determinants with P210bcr-abl since it is not recognized by anti-abl and bcr antibodies in immunoblots, is not the phosphorylated heavy chain of immunoglobulin G, and is different from p53 (the nonviral T protein) complexed to the large T antigen of simian virus 40. Previous studies (Maxwell et al., 1987) have shown that ph-P53 has a different peptide map than P210bcr-abl. Therefore, we conclude that ph-P53 is a distinct cellular protein complexed to P210bcr-abl in K562 cells.
Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16INK4A re-expression related to UHRF1 and DNMT1 down-regulation (2013)

Several reports have described the potential effects of natural compounds as anti-cancer agents in vitro as well as in vivo. The aim of this study was to evaluate the anti-cancer effect of Limoniastrum guyonianum aqueous gall extract (G extract) and luteolin in the human cervical cancer HeLa cell line, and, if so, to clarify the underlying mechanism. Our results show that G extract and luteolin inhibited cell proliferation and induced G2/M cell cycle arrest in a concentration and time-dependent manner. Both natural products induced programmed cell death as confirmed by the presence of hypodiploid G0/G1 cells. These effects are associated with an up-regulation of the expression of the tumor suppressor gene p16INK4A and a down-regulation of the expression of the anti-apoptotic actor UHRF1 and its main partner DNMT1. Moreover, G extract- and luteolin-induced UHRF1 and DNMT1 down-regulation is accompanied with a global DNA hypomethylation in HeLa cell line. Altogether our results show that G extract mediates its growth inhibitory effects on human cervical cancer HeLa cell line likely via the activation of a p16INK4A-dependent cell cycle checkpoint signalling pathway orchestrated by UHRF1 and DNMT1 down-regulation.
Analysis and visualization of TLS motion in proteins using the mmLib toolkit (2005)

reviewers, editors and readers, with practical advice on how to get the best out of the journals. So, if you ever wondered what happens to your article during the submission, review and production stages, want to know more about current publication and editorial procedures, or wish to discover quick ways of accessing and searching the journals, then you should attend this session. Various live demonstrations of the work of the IUCr Editorial Office will be included, with opportunities to ask questions throughout the session.
Dynamic Scan Chain Partitioning for Reducing Peak Shift Power During Test (2009)

Scan chain partitioning techniques are quite effective in reducing test power, as the rippling in the clock network, scan chains, and logic is reduced altogether. Partitioning approaches implemented in a static manner may fail to reduce peak power down to the desired level, however, depending on the transition distribution of the problematic pattern in the statically constructed scan chain partitions. In this paper, we propose a dynamic partitioning approach capable of adapting to the transition distribution of any test pattern and, thus, of delivering near-perfect peak power reductions. The proposed dynamic partitioning hardware allows for the partitioning reconfiguration on a per test pattern basis, hence delivering a solution that is <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">test</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">set</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">independent</i> , yet its quality is superior to that of any test set dependent solution.
A Possible Link between Infection with Burkholderia Bacteria and Systemic Lupus Erythematosus Based on Epitope Mimicry (2008)

We previously demonstrated that purified polyclonal and monoclonal anti-dsDNA antibodies bind a 15-mer peptide ASPVTARVLWKASHV in ELISA and Dot blot. This 15-mer peptide partial sequence ARVLWKASH shares similarity with burkholderia bacterial cytochrome B 561 partial sequence ARVLWRATH. In this study, we show that purified anti-dsDNA antibodies react with burkholderia fungorum bacterial cell lysates in Western blot. We used anti-dsDNA antibodies to make an anti-dsDNA antibodies affinity column and used this column to purify the burkholderia fungorum bacterial protein. Purified anti-dsDNA antibodies bind specifically to purified bacterial antigen and purified bacterial antigen blocked the anti-dsDNA antibodies binding to dsDNA antigen. Sera with anti-dsDNA antibodies bind specifically to purified bacterial antigen. We obtained protein partial sequence of RAGTDEGFG which is shared with burkholderia bacterial transcription regulator protein sequence. Sera with anti-dsDNA antibodies bind to RAGTDEGFG peptide better than control groups. These data support our hypothesis that the origin of anti-dsDNA antibodies in SLE may be associated with burkholderia bacterial infection.
B cell acute lymphoblastic leukemia cells mediate RANK-RANKL–dependent bone destruction (2020)

Although most children survive B cell acute lymphoblastic leukemia (B-ALL), they frequently experience long-term, treatment-related health problems, including osteopenia and osteonecrosis. Because some children present with fractures at ALL diagnosis, we considered the possibility that leukemic B cells contribute directly to bone pathology. To identify potential mechanisms of B-ALL-driven bone destruction, we examined the <i>p53</i> <sup>-/-</sup>; <i>Rag2</i> <sup>-/-</sup>; <i>Prkdc<sup>scid/scid</sup></i> triple mutant (TM) mice and <i>p53</i> <sup>-/-</sup>; <i>Prkdc<sup>scid/scid</sup></i> double mutant (DM) mouse models of spontaneous B-ALL. In contrast to DM animals, leukemic TM mice displayed brittle bones, and the TM leukemic cells overexpressed <i>Rankl</i>, encoding receptor activator of nuclear factor κB ligand. RANKL is a key regulator of osteoclast differentiation and bone loss. Transfer of TM leukemic cells into immunodeficient recipient mice caused trabecular bone loss. To determine whether human B-ALL can exert similar effects, we evaluated primary human B-ALL blasts isolated at diagnosis for RANKL expression and their impact on bone pathology after their transplantation into NOD.<i>Prkdc<sup>scid/scid</sup>Il2rg<sup>tm1Wjl</sup></i> /SzJ (NSG) recipient mice. Primary B-ALL cells conferred bone destruction evident in increased multinucleated osteoclasts, trabecular bone loss, destruction of the metaphyseal growth plate, and reduction in adipocyte mass in these patient-derived xenografts (PDXs). Treating PDX mice with the RANKL antagonist recombinant osteoprotegerin-Fc (rOPG-Fc) protected the bone from B-ALL-induced destruction even under conditions of heavy tumor burden. Our data demonstrate a critical role of the RANK-RANKL axis in causing B-ALL-mediated bone pathology and provide preclinical support for RANKL-targeted therapy trials to reduce acute and long-term bone destruction in these patients.
Markov reward models: application domains and solution methods (1987)

Patients with myeloproliferative neoplasms (MPNs), such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are at increased risk for arterial and venous thrombosis/thromboembolism. In particular, the risk of splanchnic venous thrombosis, such as portal vein thrombosis or Budd-Chiari syndrome, is significantly higher in patients with MPN than in the normal population. At the same time, MPN patients are at increased risk for severe bleeding. Therefore, the treatment of patients with MPN must be based on their suspected probability of thrombosis/thromboembolism and bleeding. For this purpose, patient and MPN-specific risk factors are used. Patients at expected high risk of thrombosis should receive adequate primary or secondary thromboprophylaxis in addition to cytoreductive therapy. This may consist of antiplatelet agents and/or anticoagulant agents and must be balanced with the individual bleeding risk. The goal is to increase the quality of life and life span of patients with MPNs by preventing (re-)thrombosis and severe bleeding.
Learning-based feature extraction for active 3D scan with reducing color crosstalk of multiple pattern projections (2017)

3D reconstruction methods based on active stereo technique have been widely used for many practical systems. Many of these systems are configured with a single camera and a single projector. Since such systems can only capture one side of the target object, several attempts have been conducted to enlarge the captured area, especially multi-projector systems attract many researchers. For multi-projector based systems, overlap between multiple pattern projections is a serious problem. Even if different color channels are used for each projector, complete separation is not possible because of color crosstalks. Another open problem is decoding errors of the projected patterns, which causes a failure on extracting positional information of the projected pattern form the captured image. Among several reasons for such errors, color crosstalks are crucial because their features are similar to the main signal and difficult to be decomposed. In this paper, we solve these problems by utilizing machine learning techniques where a convolutional neural network is trained to extract low dimensional pattern features for each projector. In addition, it is trained to suppress the color crosstalks from different projectors. Using this new technique, we succeeded in reconstructing 3D shapes from images where multiple patterns are overlapped.
Procédés de conversion d'énergie : batteries, piles à combustible et procédés non électriques (2010)

National audience
1D inversion and resolution analysis of marine CSEM data (2007)

Abstract We present results from an investigation into 1D inversion of controlled-source electromagnetic (CSEM) data. Based on inspection of a data set, we formulate a simple empirical noise model described by a few pragmatically determined parameters. We also investigate the effects of transmitter height above the seafloor and include the data uncertainty resulting from varying transmitter height in our noise model. Based on the noise model and assumptions about the available data, we analyze model parameter uncertainty estimates derived from the a posteriori model covariance matrix for a resistive layer buried at depth. We find that the layer parameters uncertainty primarily depends on the depth of burial and the thickness of the layer. We then formulate quantitative bounds for these parameters, within which we have a small uncertainty of the parameters of the resistive layer. The depth of burial and the transverse resistance of the layer become better determined the higher its resistance. We invert a field data set with multilayer and four-layer models and find a resistive layer at a depth of 1500–1600m below the seafloor. Seismic results from the area indicate a depth of 2000m.
Intestinal infection regulates behavior and learning via neuroendocrine signaling (2019)

The recognition of pathogens and subsequent activation of defense responses are critical for the survival of organisms. The nematode <i>Caenorhabditis elegans</i> recognizes pathogenic bacteria and elicits defense responses by activating immune pathways and pathogen avoidance. Here we show that chemosensation of phenazines produced by pathogenic <i>Pseudomonas aeruginosa</i>, which leads to rapid activation of DAF-7/TGF-β in ASJ neurons, is insufficient for the elicitation of pathogen avoidance behavior. Instead, intestinal infection and bloating of the lumen, which depend on the virulence of <i>P. aeruginosa</i>, regulates both pathogen avoidance and aversive learning by modulating not only the DAF-7/TGF-β pathway but also the G-protein coupled receptor NPR-1 pathway, which also controls aerotaxis behavior. Modulation of these neuroendocrine pathways by intestinal infection serves as a systemic feedback that enables animals to avoid virulent bacteria. These results reveal how feedback from the intestine during infection can modulate the behavior, learning, and microbial perception of the host.
MECHANISMS IN ENDOCRINOLOGY: Insulin and type 1 diabetes: immune connections (2012)

Insulin is the hormone produced by pancreatic β-cells, with a central role in carbohydrate and fat metabolism. Together with its precursors preproinsulin and proinsulin, insulin is also a key target antigen (Ag) of the autoimmune islet destruction leading to type 1 diabetes. Being recognized by both autoantibodies (aAbs) and autoreactive T cells, insulin plays a triggering role, at least in rodent models, in diabetes pathogenesis. It is expressed not only by β-cells but also in the thymus, where it plays a major role in central tolerance mechanisms. We will summarize current knowledge concerning insulin, its role in β-cell autoimmunity as initial target Ag, its recognition by aAbs and autoreactive T cells, and the detection of these immune responses to provide biomarkers for clinical trials employing insulin as an immune modulatory agent.
Investigation on the Drying Kinetics in a Pulsed Fluidized Bed (2004)

For uniform drying of large particles, a modified fluidized bed with a continuous fluidizing air flow plus one stream of pulsing air, which is termed as a pulsed fluidized bed (PFB), was developed to eliminate some limitations of conventional fluidized beds (FB). The drying kinetics of activated alumina was investigated to assess the advantages of PFB, in comparison with the results obtained in the FB. At the same average air flow rate, the bed is easy to fluidize in the PFB operation and there is little temperature difference along the bed height. Due to the dispersion of particles by pulsing flow, the drying rate for activated alumina is higher to some extent in PFB than that in FB during the constant drying period even at low average superficial air velocity.
Epitaxy of Graphene on 3C-SiC(111) Thin Films on Microfabricated Si(111) Substrates (2012)

The epitaxy of graphene on 3C-SiC(111) formed on microfabricated Si(111) has been demonstrated. Through observations by optical microscopy, micro-Raman spectroscopy, low-energy electron diffraction, and photoelectron spectroscopy, it has been confirmed that the epitaxial graphene is Bernal-stacked with a buffer layer present between graphene and the 3C-SiC film, which can lead to the opening of the band gap necessary for logic operations. The quality of graphene is improved by the shrinkage of the pattern. These results indicate that graphene on silicon using the microfabricated substrate is a promising material for the realization of graphene-based devices.