gebhart/patrepeval huggingface dataset:
User stickiness in mobile games (2022)

The continuous development of information technology in social needs has promoted the development of the mobile game industry, making games an important cultural and entertainment consumer product. The game industry became a huge dividend market. However, the booming game industry is highly competitive. How to maintain its competitiveness has become an urgent problem to be solved. This research aims at the related factors that affect users' game stickiness, such as user-perceived quality, switching cost, and perceived ease of use are focused as the primary concerns of this research. Combining the characteristics of games and users' behaviour, a structural equation model is constructed. Through the questionnaire survey and structural equation analysis, it is found that sociality, payment mechanism, user interface and plot have positive effects on game stickiness. Finally, based on the idea of behavioural design and the analysis results, this paper proposed some systematic improvement strategies for game stickiness.
Toward a Behavioral Design System: An Agent-Based Approach for Polygonal Surfaces Structures (2015)

The following research investigates the development of an agent-based design method as an integrative design tool for polygonal surface structures. The aim of this research is to develop a computational tool that self-organizes the emergence of polygonal surface structures from interaction between its constitutive lattices. This research focuses on the ethological level of morphogenesis that is relevant to the animal or insect societies, whereby agents mediate the material organizations with environmental aspects. Meanwhile, behavior-based approaches are investigated as a bottom-up system to develop a computational framework in which the lower-level features constantly interact. The lower-level features such as material properties (e.g., geometric descriptions) are abstracted into building blocks or agents to construct the agent’s morphology. The abstracted principles, which define the agent’s morphology, are aggregated into a generative tool to explore the emergent complexities. This exploration coupled with the generative constraint mechanisms steers the collective agents system toward the cloud of solutions; hence, the collective behaviors of agents constitute the polygonal surface structures. This polygonal system is a bottom up approach of developing the complex surface that emerges through topological and topographical interaction between cells and their surrounding environment. Subsequently, the integrative system is developed through agent-based parametric modelling, in which the knowledge-based system as a top-down approach is substituted with the agent system together with its morphological features and significant behaviors.
Daclatasvir plus Sofosbuvir with or without Ribavirin in patients infected with HCV genotype 3: Interim results of a multicenter compassionate use program in Europe (2015)

Einleitung: Treatment of HCV genotype 3 (GT3) infection remains a high medical need. Compared to HCV non-GT3, pts with HCV GT3 have faster rates of fibrosis progression, higher prevalence of severe steatosis, and a higher incidence of hepatocellular carcinoma. Treatment options for HCV GT3 pts are limited, and debate continues on the optimal regimen and duration of treatment, especially in those with cirrhosis. This analysis reports interim findings from a compassionate use program (CUP) of Daclastavir (DCV) plus Sofosbuvir (SOF) with or without Ribavirin (RBV) opened in 5 European countries.
Immunoglobulin E in Chronic Middle Ear Effusions (1976)

A total of 61 middle ear effusions and matched sera obtained from patients suffering from chronic otitis media with effusions (OME) was examined for IgE and other immunoglobulins to see if a reaginic antibody is involved in OME. The IgE levels were determined by the Phadebas IgE radioimmunoassay test. Excluding one patient who had extremely high IgE as a result of parasitosis, there were only three cases which showed marginally increased serum IgE levels. Elevated IgE levels in sera and/or in effusions were unrelated to a history of allergy. The mucoid effusions had significantly higher effusion levels than the levels in corresponding sera (p less than .0005). Fourteen percent of the cases examined showed effusion IgE levels five times or more higher than serum levels. Biopsy specimens of these patients showed numerous degranulating mast cells. Only two specimens showed eosinophilic infiltration. It is suggested that the IgE is produced locally by the mucosa in mucoid-type effusions and may have been involved in mast cell degranulation. However, this study cannot confirm the allergic nature of the OME.
Standardisation of bioelectrical impedance analysis for the estimation of body composition in healthy paediatric populations: a systematic review (2017)

If the BIA technique should be accepted clinically for routine use in paediatric populations, there is a need for an increased focus on the importance of improved standardisation and its reporting in future studies. Consequently, this review contains recommendations for performing and reporting BIA measurements in a standardised manner.
Regulation of Influenza A Virus Nucleoprotein Oligomerization by Phosphorylation (2014)

In the influenza virus ribonucleoprotein complex, the oligomerization of the nucleoprotein is mediated by an interaction between the tail-loop of one molecule and the groove of the neighboring molecule. In this study, we show that phosphorylation of a serine residue (S165) within the groove of influenza A virus nucleoprotein inhibits oligomerization and, consequently, ribonucleoprotein activity and viral growth. We propose that nucleoprotein oligomerization in infected cells is regulated by reversible phosphorylation.
Situated computing: bridging the gap between intention and action (2003)

Situated computing represents a new class of computing applications that bridges the gap between people's intentions and the actions they can take to achieve those intentions. These applications are contextually embedded in real-world situations, and are enabled by the proliferation of new kinds of computing devices, expanding communication capabilities and new kinds of digital content. Three types of discontinuities give rise to intention/action gaps and provide opportunities for situated computing applications: physical discontinuities, information discontinuities and and awareness discontinuities. Several examples of applications that overcome these discontinuities are presented.
Ductal Carcinoma In Situ, Complexities and Challenges (2004)

The incidence of ductal carcinoma in situ (DCIS), a noninvasive form of breast cancer, has increased markedly in recent decades, and DCIS now accounts for approximately 20% of breast cancers diagnosed by mammography. Laboratory and patient data suggest that DCIS is a precursor lesion for invasive cancer. The appropriate classification of DCIS has provoked much debate; a number of classification systems have been developed, but there is a lack of uniformity in the diagnosis and prognostication of this disease. Further investigation of molecular markers should improve the classification of DCIS and our understanding of its relationship to invasive disease. Controversy also exists with regard to the optimal management of DCIS patients. In the past, mastectomy was the primary treatment for patients with DCIS, but as with invasive cancer, breast-conserving surgery has become the standard approach. Three randomized trials have reported a statistically significant decrease in the risk of recurrence with radiation therapy in combination with lumpectomy compared with lumpectomy alone, but there was no survival advantage with the addition of radiotherapy. Two randomized trials have suggested an additional benefit, in terms of recurrence, with the addition of adjuvant tamoxifen therapy, although in one trial the benefit was not statistically significant. Current data suggest that tamoxifen use should be restricted to patients with estrogen receptor-positive DCIS. Neither trial demonstrated a survival benefit with adjuvant tamoxifen. Ongoing and recently completed studies should provide information on outcomes in patients treated with lumpectomy alone and on the effectiveness of aromatase inhibitors as an alternative to tamoxifen.
3D-printed microelectronics for integrated circuitry and passive wireless sensors (2015)

Abstract Three-dimensional (3D) additive manufacturing techniques have been utilized to make 3D electrical components, such as resistors, capacitors, and inductors, as well as circuits and passive wireless sensors. Using the fused deposition modeling technology and a multiple-nozzle system with a printing resolution of 30 μm, 3D structures with both supporting and sacrificial structures are constructed. After removing the sacrificial materials, suspensions with silver particles are injected subsequently solidified to form metallic elements/interconnects. The prototype results show good characteristics of fabricated 3D microelectronics components, including an inductor–capacitor-resonant tank circuitry with a resonance frequency at 0.53 GHz. A 3D “smart cap” with an embedded inductor–capacitor tank as the wireless passive sensor was demonstrated to monitor the quality of liquid food (e.g., milk and juice) wirelessly. The result shows a 4.3% resonance frequency shift from milk stored in the room temperature environment for 36 h. This work establishes an innovative approach to construct arbitrary 3D systems with embedded electrical structures as integrated circuitry for various applications, including the demonstrated passive wireless sensors.
Effect of Repeat Dosing of Engineered Oncolytic Herpes Simplex Virus on Preclinical Models of Rhabdomyosarcoma (2016)

Rhabdomyosarcoma (RMS), a tumor of skeletal muscle origin, is the most common sarcoma of childhood. Despite multidrug chemotherapy regimens, surgical intervention, and radiation treatment, outcomes remain poor, especially in advanced disease, and novel therapies are needed for the treatment of these aggressive malignancies. Genetically engineered oncolytic viruses, such as herpes simplex virus-1 (HSV), are currently being explored as treatments for pediatric tumors. M002, an oncolytic HSV, has both copies of the γ<sub>1</sub>34.5 gene deleted, enabling replication in tumor cells but thwarting infection of normal, postmitotic cells. We hypothesized that M002 would infect human RMS tumor cells and lead to decreased tumor cell survival in vitro and impede tumor growth in vivo. In the current study, we demonstrated that M002 could infect, replicate in, and decrease cell survival in both embryonal (ERMS) and alveolar rhabdomyosarcoma (ARMS) cells. Additionally, M002 reduced xenograft tumor growth and increased animal survival in both ARMS and ERMS. Most importantly, we showed for the first time that repeated dosing of oncolytic virus coupled with low-dose radiation provided improved tumor response in RMS. These findings provide support for the clinical investigation of oncolytic HSV in pediatric RMS.
Surface Spark-Over Voltage on Solid Insulator in Sub-Cooled Liquid Nitrogen (2005)

Surface spark-over voltages on solid insulators in boiling and sub-cooled liquid nitrogen are studied under ac, dc and impulse voltage. The insulator structure used is a model of a power cable end. In the structure, static capacitance is formed between outer surface and inner conductor of the insulator. The spark-over voltages for several insulators were measured at gap length 60 mm or less under each voltage waveform. The spark-over voltages increase slightly with increasing gap length in boiling and sub-cooled liquid. In range of shorter gap length spark-over voltages in sub-cooled liquid are higher than those in boiling liquid nitrogen. The differences between spark-over voltages in both liquids are caused by bubbles generated due to discharge at low voltage. The spark-over voltage for the insulator with the larger static capacitance is lower than that for one with the small capacitance.
Instant polysaccharide-based emulsions: impact of microstructure on lipolysis (2017)

The development of emulsion-based products through optimisation of ingredients, reduction in energy-input during manufacture, while fulfilling healthy attributes, are major objectives within the food industry. Instant emulsions can meet these features, but comprehensive studies are necessary to investigate the effect of the initial formulation on the final microstructure and, in turn, on the in vitro lipolysis, comprising the double aim of this work. The instant emulsion is formed within 1.5-3 min after pouring the aqueous phase into the oil phase which contains a mixture of emulsifier (Tween 20), swelling particles (Sephadex) and thickeners (hydroxypropylmethylcellulose, HPMC, and guar gum, GG) under mild shearing (180 rpm). The creation of oil-in-water emulsions is monitored in situ by viscosity analysis, the final microstructure visualised by microscopy and the release of free fatty acids under simulated intestinal conditions quantified by titration. Increasing the concentration and molecular weight (M<sub>w</sub>) of GG leads to smaller emulsion droplets due to increased bulk viscosity upon shearing. This droplet size reduction is magnified when increasing the M<sub>w</sub> of HPMC or swelling capacity of viscosifying particles. In addition, in the absence of the emulsifier Tween 20, the sole use of high-Mw HPMC is effective in emulsification due to combined increased bulk viscosity and interfacial activity. Hence, optimisation of the ingredient choice and usage level is possible when designing microstructures. Finally, emulsions with larger droplet size (>20 μm) display a slower rate and lower extent of lipolysis, while finer emulsions (droplet size ≤20 μm) exhibit maximum rate and extent profiles. This correlates with the extent of emulsion destabilisation observed under intestinal conditions.
Bronchodilator Responses after Methacholine and Adenosine 5′-Monophosphate (AMP) Challenges in Children with Asthma: Their Relationships with Eosinophil Markers (2012)

BDR after AMP challenge may be more closely related to eosinophilic inflammation, compared with that after methacholine challenge.
The Electro-Optic Effect in Uniaxial Crystals of the Type X H_2PO_4 I Theoretical (1949)

When voltage is put across a crystal of the type X H2PO4, the index ellipsoid in the crystal is rotated and the length of the axes changes. Two electro-optic coefficients are necessary to describe the effect in the most general plate of the crystal. The necessity for two coefficients is shown from consideration of the crystal symmetry. The behavior of Z-cut and X-cut plates are treated in detail. For Z-cut plates with the voltage in the Z direction the crystal becomes biaxial with the plane of the optic axes at 45° to the X and Y crystallographic axis. The retardation along the normal to the plate is directly proportional to the voltage and independent of the thickness. The characteristics of the polarization interference pattern for excited X and Z plates are discussed.
Mathematical modelling of nanoparticle biodistribution: extrapolation among intravenous, oral and pulmonary administration routes (2011)

In this study, a physiological-based mathematical model was developed to describe and compare the absorption, distribution, metabolism, and elimination (ADME) of nanoparticles after intravenous (IV), oral, and pulmonary exposure. The development of the model was based on physiological principles, compartmental analysis, and mathematical modelling. The human body was separated into compartments and their mass-time profiles were simulated. Mathematical equations describing the intercompartmental transportation of nanoparticles were developed based on first order kinetics. Nanoparticle biodistribution in all the tissues and organs was analysed for comparison among the administration routes. Sensitivity of transportation coefficients were calculated for evaluation of their relative importance to the output of the model. The model indicates some interesting aspects of administration route extrapolation, explains many published observations of nanoparticle ADME and proves to give a comprehensive understanding of nanoparticle ADME compared to traditional pharmacokinetic models.
Genome Sequence of Oceanibaculum indicum Type Strain P24 (2012)

Oceanibaculum indicum type strain P24 was isolated from a polycyclic-aromatic-hydrocarbon-degrading consortium enriched from a deep-seawater sample collected from the Indian Ocean. Here we present the draft genome of strain P24(T), which contains 3,952,792 bp with a G+C content of 65.5% and contains 3,755 protein-coding genes and 45 tRNAs.
ChemInform Abstract: Transient Photoligation Behavior of Nickel Protoporphyrin Reconstituted Myoglobin and Hemoglobin. (1986)

Abstract It is demonstrated that transient resonance Raman scattering can be used to probe the molecular details of the excited state photodynamics of the nickel protoporphyrin IX complex in a variety of local environments.
HLA-DMB expression by thyrocytes: indication of the antigen-processing and possible presenting capability of thyroid cells (1999)

Expression of HLA class II molecules on thyrocytes is a characteristic feature of autoimmune thyroid disease and may lead the thyroid cells to present autoantigens to CD4+ T lymphocytes. Since HLA-DM is a critical molecule in class II-restricted antigen processing and presentation, we assessed the expression of HLA-DMB, -invariant chain (Ii), class II transactivator (CIITA) and DRA in an untransformed, pure thyrocyte strain HTV-59A. Here we report that both HLA-DMB mRNA and the protein are expressed in thyrocytes and that CIITA expression is enhanced by interferon-gamma (IFN-gamma) treatment and occurs before DMB, Ii and DRA up-regulation, suggesting CIITA expression is a requirement for antigen processing in thyrocytes. These results indicate that thyrocytes are capable of antigen processing and possibly antigen presentation to T cells.
Strukturmechanische Auslegungskonzepte für Großkomponenten einer 700°C Dampfturbine (2012)

Zur weiteren Wirkungsgradsteigerung von Kohlekraftwerken auf 50% ist eine Anhebung der Frischdampfparameter auf 700°C und 350bar notwendig. Diese sogenannte A-USC Technologie wird den erstmaligen Einsatz von Nickelbasiswerkstoffen für Großkomponenten wie Gehäusen und Rotoren von Dampfturbinen erfordern. Die Arbeit umfasst die wesentlichen benötigten strukturmechanischen Auslegungskonzepte für Nickelbasis-Großkomponenten und stellt diese in einer komponentenspezifischen Form bereit, die die direkte Anwendung im Auslegungsprozess bei Turbinenherstellern ermöglicht. Ausgehend vom erarbeiteten Gesamtkonzept werden die Konzepte zur Absicherung der Turbinenrotoren und -gehäuse gegen Kurzzeitversagen und Kriechversagen detailliert entwickelt. Die Arbeit umfasst Ansätze unterschiedlicher Komplexität und Genauigkeit für die unterschiedlichen Phasen einer Turbinenentwicklung: von einfachen Handformeln hin zu fortschrittlichen FE-basierten Dehnungsnachweisen auf Basis eines Graham-Walles Modells, welches einen Schädigungsparameter zur Berücksichtigung der Mehrachsigkeit des Spannungszustands berücksichtigt. Im letzten Teil der Arbeit werden die erstellen Konzepte an komplexen Werkstoffversuchen validiert und anhand von FE-Modellen von Dampfturbinenkomponenten wird ihre Praxistauglichkeit bestätigt.
Cluster Size Effects in the Surface-Enhanced Raman Scattering Response of Ag and Au Nanoparticle Aggregates: Experimental and Theoretical Insight (2013)

In this work we report the spectral evolution of the surface-enhanced Raman scattering (SERS) response of biotin molecules that generate the assembly of Ag and Au nanospheres (NSs) into clusters with controlled interparticle gaps during the aggregation process. The experiments are analyzed using rigorous near-field electrodynamic calculations of the enhancement produced in a close-packed cluster with a different number of NSs. Two kinetic mechanisms during the NS aggregation were identified which give rise to a different cluster size distribution and as a consequence to a different SERS response. It is found that during NS aggregation there is an initial fast growth of the SERS signals followed by a decay that reaches an almost constant value at relatively long times. These results are qualitatively explained by the trends observed in the electrodynamics calculations of the near-field enhancement as a function of the cluster size, which highlights the critical role played by radiation damping as the size of the cluster increases for small clusters (dimers and trimers), in contrast with the behavior observed for clusters with a relative greater number of particles where the decrease of the near-field enhancement is less significant. In addition, a general procedure is presented that makes it possible to perform a suitable comparison of the SERS response for tight-compact clusters, in the limit of large clusters, as long as the wavelength range of the SERS response is almost size independent. This procedure is tested for Ag and Au nanoaggregates generated in solution formed by spheres of different size, at an almost constant interparticle separation. It was found that even there are differences between the analytic enhancement factor and the calculated enhancement predicted by the electrodynamic theory in the large cluster size limit, and the trends in the SERS response of the biotin molecules are qualitatively explained by the electromagnetic (EM) mechanism for both Ag and Au clusters. These discrepancies could be indicative of a chemical contribution to the global SERS response, but a rigorous assessment of this mechanism would require additional theoretical calculations supported by experiments. Notwithstanding, the SERS enhancement results obtained with noncovalent bonded dye molecules (Coumarin 440 and Rhodamine B) that are randomly distributed in the clusters as Raman reporters, using the same large clusters as substrates (linked by biotin molecules), are in fairly good quantitative agreement with the electrodynamics model of the average SERS enhancement.
Ibuprofen and Visual Function-Reply (1976)

In Reply. —The experience of Drs Levy and Hanscom and their interpretation nicely complement the initial reports of ibuprofen-associated visual problems and illustrate the difficulty of proving drug causality in such occurrences. Our study and the paucity of later reports of eye complications during ibuprofen therapy suggest that such occurrences must be rare and idiosyncratic. Only with carefully documented individual patient experiences, submitted as letters to journals or reported to the Food and Drug Administration or the manufacturer, will we learn whether or not this is any problem at all.