gebhart/patrepeval huggingface dataset:
Biomarkers of Blood from Patients with Atherosclerosis Based on Bioinformatics Analysis (2021)

Abstract Background: atherosclerosis is a multifaceted disease characterized by the formation and accumulation of plaques that fix to the arteries and causes some cardiovascular disease and vascular embolism. A range of diagnostic techniques, including selective coronary angiography, stress tests, CT, and nuclear scans allow assessment of cardiovascular disease risk and treatment targets. However, there is not a very simple blood biochemical index or biological target for the diagnosis of atherosclerosis at present. So it would be interesting to find a blood biochemical marker for atherosclerosis.Methods: Three datasets from Gene Expression Omnibus (GEO) database were analyzed to obtain differentially expressed genes (DEG) and the results were integrated using Robustrankaggreg algorithm. The genes considered more important by Robustrankaggreg algorithm were put into their own data set and the data set system with cell classification information for verification.Results: 21 possible genes were screened out. Interestingly, we found a good correlation between RPS4Y1 , EIF1AY and XIST . In addition, we know the general expression of these genes in different cell types and whole blood cellsConclusions: In this study, we identified BTNL8 and BLNK as having good clinical significance. These results will contribute to the study of the underlying genes involved in the progression of atherosclerosis and provide insights for the discovery of new diagnostic and evaluation methods.
Conduction mechanisms in some graphite - polymer composites: the effect of a direct-current electric field (1997)

This paper deals with the possible conduction mechanisms in highly anisotropic composites comprising 0 - 10 vol% graphite flakes within a polymer host. Conductivity measurements as a function of DC electric field have been made. In most cases, a non-linear behaviour of the current - voltage relationships is observed. A number of theoretical models are considered and we show that none of them is, by itself, able to explain our results. We further develop several arguments which lead us to consider the existence of a combined tunnelling effect and ionic conduction mechanism.
The Vector Floating-Point Unit in a Synergistic Processor Element of a CELL Processor (2005)

The floating-point unit in the synergistic processor element of the 1st generation multi-core CELL processor is described. The FPU supports 4-way SIMD single precision and integer operations and 2-way SIMD double precision operations. The design required a high-frequency, low latency, power and area efficiency with primary application to the multimedia streaming workloads, such as 3D graphics. The FPU has 3 different latencies, optimizing the performance critical single precision FMA operations, which are executed with a 6-cycle latency at an 11FO4 cycle time. The latency includes the global forwarding of the result. These challenging performance, power, and area goals were achieved through the co-design of architecture and implementation with optimizations at all levels of the design. This paper focuses on the logical and algorithmic aspects of the FPU we developed, to achieve these goals.
ChemInform Abstract: ENOLESTER DER ORTHOCARBONSAEUREN (1970)

Abstract In einer allgemein anwendbaren Methode werden die Orthocarbonsäureenolester (IV) in einem Zweistufenverfahren dargestellt: 1. HCl‐katalysierte Umesterung der Orthoäthylester (I) mit den 2‐Chlor‐alkanolen (II) bei 80°C /60 bis 70 Torr zu den Chloralkylestern (III).
Mass Spectrometry of Intact V-Type ATPases Reveals Bound Lipids and the Effects of Nucleotide Binding (2011)

The ability of electrospray to propel large viruses into a mass spectrometer is established and is rationalized by analogy to the atmospheric transmission of the common cold. Much less clear is the fate of membrane-embedded molecular machines in the gas phase. Here we show that rotary adenosine triphosphatases (ATPases)/synthases from Thermus thermophilus and Enterococcus hirae can be maintained intact with membrane and soluble subunit interactions preserved in vacuum. Mass spectra reveal subunit stoichiometries and the identity of tightly bound lipids within the membrane rotors. Moreover, subcomplexes formed in solution and gas phases reveal the regulatory effects of nucleotide binding on both ATP hydrolysis and proton translocation. Consequently, we can link specific lipid and nucleotide binding with distinct regulatory roles.
Highly efficient blue light based on periodically poled 6.5mol% MgO-doped LiNbO 3 (2005)

6.5 mol.% MgO-doped LiNbO<sub>3</sub> (MgLN) single crystal has been grown by the Czochralski technique. The MgO-doped crystal shows a shift in the absorption edge towards shorter wavelengths and a three orders of magnitude increase in the photorefractive damage resistance compared to the congruent LiNbO<sub>3</sub> crystal (CLN). This material has been periodically poled (PP) at room temperature by applying electric field, and the coercive field is 5 KV/mm, which is about 1/4 of that for congruent LiNbO<sub>3</sub>. Periodic poling of 1 mm thick 6.5 mol.% MgO-doped LiNbO<sub>3</sub> substrates has been successfully performed and its operation in a femtosecond second-harmonic generation at room temperature. The performance of quasi-phase-matched second harmonic generation with a 1mm thick PP MgO:LN was compared with that of the second harmonic generation with the PP CLN at room temperature. The PP MgO:LN exhibited better performance.
Influence of antidepressant pharmacotherapy on behavioral treatment adherence and smoking cessation outcome in a combined treatment involving fluoxetine. (2001)

The authors examined whether serum fluoxetine levels influence behavioral treatment adherence and smoking cessation outcome. Nondepressed smokers (N = 989) from 16 centers were randomized on a double-blind basis to receive either fluoxetine (30 or 60 mg) or placebo plus 9 sessions of behavioral smoking cessation treatment. Fluoxetine and norfluoxetine blood levels were assayed 1 week after the quit date. Logistic regression was used to predict treatment completion and cessation outcome, controlling for gender, age, treatment site, and degree of nicotine dependence. Higher steady-state fluoxetine blood levels (fluoxetine + norfluoxetine) predicted less likelihood of dropping out, chi2(1, N = 820) = 3.9, p < .05, and more likelihood of being abstinent, chi2(1, N = 513) = 18.1, p < .001. Attaining a higher fluoxetine blood level improved the likelihood of completing behavioral treatment and increased the probability of achieving abstinence.
Evaluation of innovative operation concept for flat sheet MBR filtration system (2008)

One of the most limiting factors for the extension and acceptance of MBR filtration systems for municipal and industrial wastewater is the impact of membrane fouling on maintenance, operation and cleaning efforts. One field of action in the European Research Project "AMEDEUS" is the development and testing of MBR module concepts with innovative fouling-prevention technology from three European module manufacturers. This article deals with the performances of the flat-sheet modules by A3 Water Solutions GmbH in double-deck configuration evaluated over 10 months in Anjou Recherche under typical biological operation conditions for MBR systems (MLSS = 10 g/l; SRT = 25 days). By using a double-deck configuration, it is possible to operate with a net flux of 25.5 l/m2.h at 20 degrees C, a membrane air flow rate of 0.21 Nm3/h.m2 of membrane to achieve a stable permeability of around 500-600 l/m2.h.bar. Additionally, it was observed that it is possible to recover the membrane performance after biofouling during operation without intensive cleaning and to maintain stable permeability during peak flows. The evaluated concepts for equipping and operating MBR systems will be applied to several full-scale plants constructed by A3 Water Solutions GmbH.
Bi–Sb Nanocrystals Embedded in Phosphorus as High-Performance Potassium Ion Battery Electrodes (2020)

The development of high-performance potassium ion battery (KIB) electrodes requires a nanoengineering design aimed at optimizing the construction of active material/buffer material nanocomposites. These nanocomposites will alleviate the stress resulting from large volume changes induced by K<sup>+</sup> ion insertion/extraction and enhance the electrical and ion conductivity. We report the synthesis of phosphorus-embedded ultrasmall bismuth-antimony nanocrystals (Bi<sub><i>x</i></sub>Sb<sub>1-<i>x</i></sub>@P, (0 ≤ <i>x</i> ≤ 1)) for KIB anodes <i>via</i> a facile solution precipitation at room temperature. Bi<sub><i>x</i></sub>Sb<sub>1-<i>x</i></sub>@P nanocomposites can enhance potassiation-depotassiation reactions with K<sup>+</sup> ions, owing to several attributes. First, by adjusting the feed ratios of the Bi/Sb reactants, the composition of Bi<sub><i>x</i></sub>Sb<sub>1-<i>x</i></sub> nanocrystals can be systematically tuned for the best KIB anode performance. Second, extremely small (diameter ≈ 3 nm) Bi<sub><i>x</i></sub>Sb<sub>1-<i>x</i></sub> nanocrystals were obtained after cycling and were fixed firmly inside the P matrix. These nanocrystals were effective in buffering the large volume change and preventing the collapse of the electrode. Third, the P matrix served as a good medium for both electron and K<sup>+</sup> ion transport to enable rapid charge and discharge processes. Fourth, thin and stable solid electrolyte interface (SEI) layers that formed on the surface of the cycled Bi<sub><i>x</i></sub>Sb<sub>1-<i>x</i></sub>@P electrodes resulted in low resistance of the overall battery electrode. Lastly, <i>in situ</i> X-ray diffraction analysis of K<sup>+</sup> ion insertion/extraction into/from the Bi<sub><i>x</i></sub>Sb<sub>1-<i>x</i></sub>@P electrodes revealed that the potassium storage mechanism involves a simple, direct, and reversible reaction pathway: (Bi, Sb) ↔ K(Bi, Sb) ↔ K<sub>3</sub>(Bi, Sb). Therefore, electrodes with the optimized composition, <i>i.e.</i>, Bi<sub>0.5</sub>Sb<sub>0.5</sub>@P, exhibited excellent electrochemical performance (in terms of specific capacity, rate capacities, and cycling stability) as KIB anodes. Bi<sub>0.5</sub>Sb<sub>0.5</sub>@P anodes retained specific capacities of 295.4 mA h g<sup>-1</sup> at 500 mA g<sup>-1</sup> and 339.1 mA h g<sup>-1</sup> at 1 A g<sup>-1</sup> after 800 and 550 cycles, respectively. Furthermore, a capacity of 258.5 mA h g<sup>-1</sup> even at 6.5 A g<sup>-1</sup> revealed the outstanding rate capability of the Sb-based KIB anodes. Proof-of-concept KIBs utilizing Bi<sub>0.5</sub>Sb<sub>0.5</sub>@P as an anode and PTCDA (perylenetetracarboxylic dianhydride) as a cathode were used to demonstrate the applicability of Bi<sub>0.5</sub>Sb<sub>0.5</sub>@P electrodes to full cells. This study shows that Bi<sub><i>x</i></sub>Sb<sub>1-<i>x</i></sub>@P nanocomposites are promising carbon-free anode materials for KIB anodes and are readily compatible with the commercial slurry-coating process applied in the battery manufacturing industry.
Cyclic monoterpenoid feeding deterrents from the red marine alga Ochtodes crockeri (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclic monoterpenoid feeding deterrents from the red marine alga Ochtodes crockeriValerie J. Paul, Oliver J. McConnell, and William FenicalCite this: J. Org. Chem. 1980, 45, 17, 3401–3407Publication Date (Print):August 1, 1980Publication History Published online1 May 2002Published inissue 1 August 1980https://pubs.acs.org/doi/10.1021/jo01305a006https://doi.org/10.1021/jo01305a006research-articleACS PublicationsRequest reuse permissionsArticle Views185Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Applied Plasma Medicine (2008)

Abstract An emerging field of plasma medicine is discussed, where non‐equilibrium plasmas are shown to be able to initiate, promote, control, and catalyze various complex behaviors and responses in biological systems. More importantly, it will be shown that plasma can be tuned to achieve the desired medical effect, especially in medical sterilization and treatment of different kind of skin diseases. Wound healing and tissue regeneration can be achieved following various types of plasma treatment in a multitude of wound pathologies. Non‐equilibrium plasmas will be shown to be non‐destructive to tissue, safe, and effective in inactivation of various parasites and foreign organisms. magnified image
An Empirical Comparison of Instance Attribution Methods for NLP (2021)

Widespread adoption of deep models has motivated a pressing need for approaches to interpret network outputs and to facilitate model debugging. Instance attribution methods constitute one means of accomplishing these goals by retrieving training instances that (may have) led to a particular prediction. Influence functions (IF; Koh and Liang 2017) provide machinery for doing this by quantifying the effect that perturbing individual train instances would have on a specific test prediction. However, even approximating the IF is computationally expensive, to the degree that may be prohibitive in many cases. Might simpler approaches (e.g., retrieving train examples most similar to a given test point) perform comparably? In this work, we evaluate the degree to which different potential instance attribution agree with respect to the importance of training samples. We find that simple retrieval methods yield training instances that differ from those identified via gradient-based methods (such as IFs), but that nonetheless exhibit desirable characteristics similar to more complex attribution methods. Code for all methods and experiments in this paper is available at: https://github.com/successar/instance_attributions_NLP.
A portable powered ankle-foot orthosis for rehabilitation (2011)

Innovative technological advancements in the field of orthotics, such as portable powered orthotic systems, could create new treatment modalities to improve the functional out come of rehabilitation. In this article, we present a novel portable powered ankle-foot orthosis (PPAFO) to provide untethered assistance during gait. The PPAFO provides both plantar flexor and dorsiflexor torque assistance by way of a bidirectional pneumatic rotary actuator. The system uses a portable pneumatic power source (compressed carbon dioxide bottle) and embedded electronics to control the actuation of the foot. We collected pilot experimental data from one impaired and three nondisabled subjects to demonstrate design functionality. The impaired subject had bilateral impairment of the lower legs due to cauda equina syndrome. We found that data from nondisabled walkers demonstrated the PPAFO's capability to provide correctly timed plantar flexor and dorsiflexor assistance during gait. Reduced activation of the tibialis anterior during stance and swing was also seen during assisted nondisabled walking trials. An increase in the vertical ground reaction force during the second half of stance was present during assisted trials for the impaired subject. Data from nondisabled walkers demonstrated functionality, and data from an impaired walker demonstrated the ability to provide functional plantar flexor assistance.
China’s experience in reforming its state-owned enterprises: Something new, something old and something Chinese? (2013)

A B S T R A C T It has been over thirty years since China has instigated reforms to their state-owned enterprises (SOEs). China's brand of reforms is a blend of selective adaptation of good corporate governance ideals. Recent introduction of new laws and governmental oversights have helped the government to retain near absolute control. The only palatable explanation is that this is a state crafted modern socialistic market with 'Chinese characteristics' - that is, the modernisation of the Chinese SOEs through the selective use of international governance standards as a guide and the establishment of a new form of state led paternalistic governance.
Scalable programmable inbound traffic engineering (2015)

With the rise of video streaming and cloud services, enterprise and access networks receive much more traffic than they send, and must rely on the Internet to offer good end-to-end performance. These edge networks often connect to multiple ISPs for better performance and reliability, but have only limited ways to influence which of their ISPs carries the traffic for each service. In this paper, we present Sprite, a software-defined solution for flexible inbound traffic engineering (TE). Sprite offers direct, fine-grained control over inbound traffic, by announcing different public IP prefixes to each ISP, and performing source network address translation (SNAT) on outbound request traffic. Our design achieves scalability in both the data plane (by performing SNAT on edge switches close to the clients) and the control plane (by having local agents install the SNAT rules). The controller translates high-level TE objectives, based on client and server names, as well as performance metrics, to a dynamic network policy based on real-time traffic and performance measurements. We evaluate Sprite with live data from "in the wild" experiments on an EC2-based testbed, and demonstrate how Sprite dynamically adapts the network policy to achieve high-level TE objectives, such as balancing YouTube traffic among ISPs to improve video quality.
Comorbidity is an independent predictor of complete remission in elderly patients receiving induction chemotherapy for acute myeloid leukemia (2007)

: The results from this study indicated that associated comorbidities are independent factors that may influence achievement of CR in elderly patients with AML. Such a scoring system may be useful in the prognostic staging systems that are used to identify patients with AML who can benefit from induction chemotherapy.
Precision Solar Spectroscopy with Near Infrared Laser Heterodyne Radiometry (2021)

With frequency-comb-calibrated laser heterodyne radiometry, we perform near-quantum-limited solar spectroscopy at 1565 nm. Solar spectral lines are resolved to 1 part in 1400 in 10 minutes of averaging.
Data from MDM2 inhibition enhances immune checkpoint inhibitor efficacy by increasing IL-15 and MHC class II production (2023)

&lt;div&gt;Abstract&lt;p&gt;The treatment of metastatic melanoma patients with immune checkpoint inhibitors (ICI) leads to impressive response rates but primary and secondary resistance to ICI reduce progression-free survival. Novel strategies that interfere with resistance mechanisms are key to further improve patient outcome during ICI therapy. P53 is often inactivated by mouse-double-minute-2 (MDM2), which may decrease immunogenicity of melanoma cells. We analyzed primary patient-derived melanoma cell lines, performed bulk sequencing analysis of patient-derived melanoma samples and used melanoma mouse models to investigate the role of MDM2-inhibition for enhanced ICI therapy. We found increased expression of IL-15 and MHC-II in murine melanoma cells upon p53 induction by MDM2-inhibition. MDM2-inhibitor induced MHC-II and IL-15-production, which was p53 dependent as p53 knockdown blocked the effect. Lack of IL-15-receptor in hematopoietic cells or IL-15 neutralization reduced the MDM2-inhibition/p53-induction mediated anti-tumor immunity. p53 induction by MDM2-inhibition caused anti-melanoma immune memory as T cells isolated from MDM2-inhibitor treated melanoma bearing mice exhibited anti-melanoma activity in secondary melanoma-bearing mice. In patient-derived melanoma cells p53 induction by MDM2-inhibition increased IL-15 and MHC-II. IL-15 and CIITA expression was associated with a more favorable prognosis in patients bearing WT but not TP53 mutated melanoma. Implications: MDM2-inhibition represents a novel strategy to enhance IL-15 and MHC-II-production, which disrupts the immunosuppressive tumor microenvironment. Based on our findings a clinical trial combining MDM2-inhibition with anti-PD-1 immunotherapy for metastatic melanoma is planned.&lt;/p&gt;&lt;/div&gt;
Modeling the extended defect evolution in lateral epitaxial overgrowth of GaN: Subgrain stability (2002)

The topic of extended defect structure stability in lateral epitaxial overgrowth (LEO) of GaN is addressed. We first summarize experimental results of growth morphology and dislocation structure in LEO GaN on sapphire substrates in the context of the crystallographic orientation of the stripe window openings. For 〈112̄0〉-oriented stripes, the LEO material often exhibits a triangular cross-section morphology with inclined {101̄1} facets. The threading dislocations (TDs) propagate vertically in the window region and then become unstable and bend toward the inclined sidewalls, to eventually lie in the basal plane. In the case of 〈11̄00〉-oriented stripes, vertical {112̄0} sidewalls may develop and, when realized, yield the lowest density of extended defects in the wing (overgrown) regions. Most of the TDs propagate vertically in the window regions and remain in loosely organized cell walls (subgrain boundaries). For this stripe orientation, a discernable crystallographic tilt of the LEO wing regions relative to the window region is also observed. This tilt is related to the appearance of edge dislocation arrays in the transition region between windows and wings. To understand the growth of dislocation-free wing regions, we present a model for dislocation subboundary cell structure stability during lateral overgrowth. The model provides a relation between structural parameters (such as cell size and misorientation) under which lateral defect-free growth is energetically favorable.
Japanese-to-English and English-to-Japanese Cross-Language Question-Answering System Using Decreased Adding with Multiple Answers at NTCIR-5. (2005)

We describe a method of using multiple documents with decreasing weights as evidence to improve the performance of a question-answering system and how it was employed in cross-language question answer-ing (CLQA) tasks at NTCIR-5. Sometimes, the an-swer to a question may be found in multiple docu-ments. In such cases, using multiple documents for prediction would generate better answers than using a single document. Thus, our method employs informa-tion from multiple documents by adding the scores of the candidate answers extracted from the various doc-uments. Because simply adding scores degrades the performance of question-answering systems, we add scores with decreasing weights to reduce the nega-tive effect of simple adding. We used this method in the CLQA part of NTCIR-5. It was incorporated in a commercially available translation system that per-formed the cross-language question-answering tasks. Our method obtained relatively good CLQA results.