gebhart/patrepeval huggingface dataset:
Malignant melanoma of the extremities: A clinicopathologic study using levels of invasion (microstage) (1975)

A clinicopathologic study was done in 151 patients with malignant melanoma of the extremities who were surgically treated in Memorial Hospital and had 5-to 9-year followup. Microstaging was done according to the depth of invasion, as determined by Clark's levels as well as by direct measurement. This was related to treatment and to clinical course. There was a correlation between the depth of invasion by Clark's levels and the incidence of lymph node metastases in patients with Stage I melanoma who had elective node dissection. The incidence of nodal metastases was 4% for Level II, 7% FOR Level III, 25% for Level IV, and 70% for Level V. There was a correlation between Clark's level of invasion and survival aftter surgery. The 5-year cure rate was 100% for Level II, 88% for Level III, 60% for Level IV, and 15% for Level V melanoma. The presence of nodal metastases augured a much worse prognosis than Clark's level per se. In patients with Level IV melanoma, the 5-year cure rate was 82% in patients with negative nodes and 27% in those with nodal metastases after elective node dissection. Microstaging primary melanoma according to Clark's levels serves as a useful standard with which to compare surgical results. In this series of extremity melanomas there was no difference between local recurrence and lymphadenectomy for Level II melanoma. For Level III and Level IV melanoma, wide excision and lymphadenectomy gave higher cure rates than wide excision only, both at 5 and 9 years after surgery. The results were significant only for patients with Level III, however. Use of the measured depth of invasion added significant clinicopathologic information. The incidence of nodal metastases at elective node dissection was 5 to 9% for melanoma showing 0.6 to 2.0 mm of invasion, 22% for melanoma measuring 2.1 to 3.0 mm, and 39% for melanoma invading beyond 3.0 mm. The 5-year cure rate was 100% for melanoma measuring less than 1.0 mm, 83% for melanoma invading 1.1 to 2.0 mm, 58% for lesions measuring 2.1 to 3.0 mm, and 55% for melanoma invading over 3.0 mm. The microstage technique combining Clark's levels and the measured depth of invasion has an important use as a prognostic index and as a standard upon which to select treatment for primary melanoma of the extremities.
Systematic review on urine albumin testing for early detection of diabetic complications (2005)

The most pronounced benefits of glycaemic control identified in this review are on retinal and renal complications in both normoalbuminuric and microalbuminuric patients considered together, with little or no evidence of any greater benefit in those with microalbuminuria. Hence, microalbuminuric status may be a false boundary when considering the benefits of glycaemic control. Classification of a person as normoalbuminuric must not serve to suggest that they will derive less benefit from optimal glycaemic control than a person who is microalbuminuric. All hypertensive patients benefit from blood pressure lowering and there is little evidence of additional benefit in those with microalbuminuria. Antihypertensive therapy with an ACE inhibitor in normotensive patients with microalbuminuria is beneficial. Monitoring microalbuminuria does not have a proven role in modulating antihypertensive therapy while the patient remains hypertensive. Recommendations for microalbuminuria research include: determining rate and predictors of development and factors involved in regression; carrying out economic evaluations of different screening strategies; investigating the effects of screening on patients; standardising screening tests to enable use of common reference ranges; evaluating the effects of lipid-lowering therapy; and using to modulate antihypertensive therapy.
Influence of two anti-fungal Lactobacillus fermentum-Saccharomyces cerevisiae co-cultures on cocoa bean fermentation and final bean quality (2020)

The growth of filamentous fungi during the spontaneous cocoa bean fermentation leads to inferior cocoa bean quality and poses a health risk for consumers due to the potential accumulation of mycotoxins. We recently developed anti-fungal cultures with the capacity to inhibit the growth of mycotoxigenic filamentous fungi on cocoa beans. However, it is not clear how these anti-fungal cultures affect the fermentation process and cocoa bean quality. For that, the anti-fungal co-cultures, Lactobacillus fermentum M017-Saccharomyces cerevisiae H290 (A) and Lb. fermentum 223-S. cerevisiae H290 (B), were applied to 180-kg box fermentations in Honduras in three time-independent replications each including a spontaneous control fermentation. The comparison of inoculated and spontaneous fermentation processes revealed that the co-cultures only marginally affected the fermentation process and cocoa bean quality. Microorganisms reached maximal levels of 6.2-7.6 log CFU/g of yeasts and acetic acid bacteria and 7.9-9.5 log CFU/g of lactic acid bacteria during all fermentations and led to maximal metabolite concentrations in bean cotyledons of 4-12 mg/g ethanol, 2-6 mg/g lactic acid and 6-14 mg/g acetic acid. The fermentation and drying processes resulted in 38-90 mg epicatechin equivalents/g in the cotyledons of dried beans. However, the co-cultures led to up to ten times higher mannitol levels in cotyledons of inoculated beans compared to beans during spontaneous fermentation, and caused a slower fermentation process, detectable as up to 8-12 °C lower temperatures in the centre of the fermenting pulp-bean mass and up to 22% lower proportions of well-fermented beans after drying. Co-culture B-with Lb. fermentum 223 -led to improved cocoa bean quality compared to co-culture A-with Lb. fermentum M017 -, i.e. cocoa beans with 0.5-1.9 mg/g less acetic acid, 4-17% higher shares of well-fermented beans and, on a scale from 0 to 10, to 0.2-0.6 units lower astringency, up to 1.1 units lower off-flavours, and 0.2-0.9 units higher cocoa notes. Therefore, the anti-fungal co-culture B is recommended for future applications and its capacity to limit fungal growth and mycotoxin production during industrial-scale cocoa bean fermentation should be investigated in further studies.
Label-free mitosis detection in tumor spheroids using tissue dynamics imaging (2012)

The detection of cellular mitosis inside three-dimensional living tissue at depths up to 1 mm has been beyond the detection limits of conventional microscopies. In this paper, we demonstrate the use of motility contrast imaging and fluctuation spectroscopy to detect motional signatures that we attribute to mitotic events within groups of 100 cells in multicellular tumor spheroids. Motility contrast imaging is a coherence-domain speckle-imaging technique that uses low-coherence off-axis holography as a coherence gate to localize dynamic light scattering from selected depths inside tissue. Fluctuation spectroscopy is performed on a pervoxel basis to generate micro-spectrograms that display frequency content vs. time. Mitosis, especially in Telophase and Cytokinesis, is a relatively fast and high-amplitude phenomenon that should display energetic features within the micro-spectrograms. By choosing an appropriate frequency range and threshold, we detect energetic events with a density and rate that are comparable to the expected mitotic fraction in the UMR cell line. By studying these mitotic events in tumors of two different sizes, we show that micro-spectrograms contain characteristically different information content than macro-spectrograms (averaged over many voxels) in which the mitotic signatures (which are overall a low-probability event) are averaged out. The detection of mitotic fraction in thick living tissue has important consequences for the use of tissue-based assays for drug discovery.
Airway stenting with the LT-Mold™ for severe glotto-subglottic stenosis or intractable aspiration: experience in 65 cases (2012)

The purpose of this study was to assess the safety and efficacy of stenting in upper airway reconstructions for benign laryngotracheal stenosis (LTS) with a newly designed prosthesis, the LT-Mold™. The LT-Mold and its proper use during open surgery and endoscopy are described, and the experience gathered from a prospectively collected database on 65 patients treated for complex LTS or severe aspiration is reported. This series is compared to the results of other stenting methods. All patients were available for evaluation. In all but one case, the prosthesis was removed at the end of the study. The new prosthesis did not induce any stent-related trauma to the supraglottis, glottis and subglottis. Before adding a distal round-shaped silicone cap to the LT-Mold, granulation tissue was usually seen at the stent-mucosal interface at the tracheostoma level. In 14 cases, there has been a spontaneous extrusion of the prosthesis through the mouth; this problem was solved by fixing the prosthesis through the reinforced portion of the prosthesis at the cap level and by adding one fixation stitch in the supraglottis. We have to document the loss of the silicone cap in three cases. This problem was resolved by designing a new prototype with an integrated cap, glued with a slow hardening silicone glue. Fifty-four (83 %) of 65 patients were decannulated after a mean duration of stenting of 3 months (range 1-12 months). The mean follow-up after decannulation was 23 months (range 1 month to 10 years). The experience gathered with the LT-Mold shows that long-term stenting for complex LTS is safely achieved when the prosthesis is used with its distal integrated silicone cap. The softness and smoothness of the prosthesis with a round-shaped configuration of both extremities help avoid ulceration and granulation tissue formation in the reconstructed airway. Adequate fixation is mandatory to avoid extrusion.
Two-tiered Sensor Placement Approach for Large Water Distribution Systems. (2011)

Abstract not provided.
Simulation of broad spectral bandwidth emitters at 1060 nm for optical coherence tomography (2016)

The simulation of broad spectral bandwidth light sources (semiconductor optical amplifiers (SOA) and superluminescent diodes (SLD)) for application in ophthalmic optical coherence tomography is reported. The device requirements and origin of key device parameters are outlined, and a range of single and double InGaAs/GaAs quantum well (QW) active elements are simulated with a view to application in different OCT embodiments. We confirm that utilising higher order optical transitions is beneficial for single QW SOAs, but may introduce deleterious spectral modulation in SLDs. We show how an addition QW may be introduced to eliminate this spectral modulation, but that this results in a reduction of the gain spectrum width. We go on to explore double QW structures where the roles of the two QWs are reversed, with the narrow QW providing long wavelength emission and gain. We show how this modification in the density of states results in a significant increase in gain-spectrum width for a given current.
Efficient Gap‐Free Broadband Terahertz Generators Based on New Organic Quinolinium Single Crystals (2019)

Abstract New organic electro‐optic crystals containing orthogonally oriented electron‐withdrawing groups are developed for efficient and gap‐free THz wave generation with a very flat broadband spectral shape. These crystals consist of 2‐(4‐hydroxystyryl)‐1‐methylquinolinium (OHQ) cationic chromophores and nonplanar 4‐(trifluoromethoxy)benzenesulfonate (TFO) anions with orthogonally oriented highly electronegative trifluoromethoxy groups capable of strong hydrogen bonds. OHQ‐TFO crystals exhibit enhanced macroscopic optical nonlinearity with a second harmonic generation efficiency 2.3 times greater than that of benchmark OHQ‐based crystals with conventional planar anions. This enhancement is attributed to reduced edge‐to‐face π–π interactions between cations and anions due to the orthogonal orientation and electron‐withdrawing characteristics of trifluoromethoxy groups. Moreover, OHQ‐TFO crystals exhibit excellent THz wave characteristics generated by optical rectification; 0.52 mm thick OHQ‐TFO crystal generate a peak‐to‐peak THz electric field 15 times higher than that of inorganic standard 1.0 mm thick ZnTe crystal and a broader spectrum with an upper cut‐off frequency near 8 THz at pump wavelengths of 1140–1500 nm. Unlike previously reported state‐of‐the‐art organic electro‐optic salt crystals with strong phonon absorption in the frequency range of 0.8–3 THz, OHQ‐TFO crystals facilitate gap‐free broadband THz wave generation without strong absorption modulations due to the strong hydrogen bond ability of trifluoromethoxy groups.
A new cognitive technology demonstrates a link between consciousness and space-time: a pilot study (2014)

In this paper we show that parallel universes are a reality in our space-time. We used a camera and a specific cognitive technology to create a state of well-being and to interact with nature. It"s the first time that we observe the reality of our space-time using a mixture of quantum physics, relativity and cognitive science. Physicists look for a theory to understand our universe, a theory that would blend quantum mechanics with relativity, but they forget an important thing, which is consciousness. Today several ideas exist. The approaches are theoretical and the experiments difficult to carry out. This experimental work proposes to blend physics and cognitive science, thus showing the existence of parallel universe and the existence of light entities or new phenomena in our space-time. Therefore, this work indicates that consciousness plays an important part in the understanding of our universe and of time.
Interconversion among Dianionic, Anionic, and Neutral Compounds Bearing a Bond between Two Pentacoordinated Germanium Atoms (2014)

The first dianionic compounds bearing a bond between two pentacoordinated germanium atoms have been synthesized in a stable form as candidates for a core unit to construct unprecedented structures in group 14 element chemistry. X-ray crystallographic analysis and computational study indicated the single-bond character of the Ge–Ge bond. They were reversibly converted to the anionic and neutral Ge–Ge-bonded compounds while maintaining the coordination number of the germanium atoms. The interconversion features changes in structures around the germanium atoms, including changes from a staggered conformation of the Ge–O bonds to a parallel conformation.
A monoclonal antibody to human angiogenin suppresses tumor growth in athymic mice. (1994)

Human angiogenin, a potent inducer of neovascularization, is secreted by HT-29 colon adenocarcinoma cells. microgram doses of a monoclonal antibody that neutralizes the in vitro and in vivo activities of angiogenin prevent or delay the appearance of s.c. HT-29 tumors in athymic mice in a statistically significant, dose-dependent manner. The antibody is not cytotoxic to tumor cells in vitro, which indicates that inhibition of tumor growth most likely occurs by neutralization of the activity of angiogenin in vivo and further implies a critical role for angiogenin in the early development of HT-29 tumors. The results suggest a therapeutically useful approach to the treatment of angiogenin-dependent malignancy.
Comparison of HPLC and Small Column (CDTect) Methods for Disialotransferrin (2001)

The HPLC anion-exchange method for quantification of CDT provides substantially better separation between moderate and heavy drinkers than the CDTect method.
Supplementary Fig. S1 legend from Nuclear factor-κB activation: a molecular therapeutic target for estrogen receptor–negative and epidermal growth factor receptor family receptor–positive human breast cancer (2023)

Supplementary Fig. S1 legend from Nuclear factor-κB activation: a molecular therapeutic target for estrogen receptor–negative and epidermal growth factor receptor family receptor–positive human breast cancer
Identification of Chromosomal Genes in Yersinia pestis that Influence Type III Secretion and Delivery of Yops into Target Cells (2012)

Pathogenic Yersinia species possess a type III secretion system, which is required for the delivery of effector Yop proteins into target cells during infection. Genes encoding the type III secretion machinery, its substrates, and several regulatory proteins all reside on a 70-Kb virulence plasmid. Genes encoded in the chromosome of yersiniae are thought to play important roles in bacterial perception of host environments and in the coordinated activation of the type III secretion pathway. Here, we investigate the contribution of chromosomal genes to the complex regulatory process controlling type III secretion in Yersinia pestis. Using transposon mutagenesis, we identified five chromosomal genes required for expression or secretion of Yops in laboratory media. Four out of the five chromosomal mutants were defective to various extents at injecting Yops into tissue culture cells. Interestingly, we found one mutant that was not able to secrete in vitro but was fully competent for injecting Yops into host cells, suggesting independent mechanisms for activation of the secretion apparatus. When tested in a mouse model of plague disease, three mutants were avirulent, whereas two strains were severely attenuated. Together these results demonstrate the importance of Y. pestis chromosomal genes in the proper function of type III secretion and in the pathogenesis of plague.
Characteristics of Erectile Dysfunction as a Function of Medical Care System Entry Point (1981)

The scientific literature on the treatment of penile erectile dysfunction contains numerous contradictory reports on the relative frequency of organic causes of impotence and the treatment results of behavioral sex therapy. One explanation for these contradictory findings is the hypothesis that different investigators are studying different subsamples of the symptomatic population. This study investigated differences in characteristics of men who initially consulted a urologist with a complaint of impotence versus those who self-referred themselves to a sexual dysfunction clinic. Self-referred sexual dysfunction patients were more often white, more often had psychogenic etiologies to their difficulties, were more often of higher socioeconomic class, and had a much better response to psychological interventions. This study suggests that future studies concerning the etiology and treatment of impotence need to specify population characteristics such as referral source and screening criteria. It may be necessary to develop alternative treatment techniques for men who present to nonpsychiatric sources for help with psychogenic impotence.
Chest Film Clinic: What caused persistent cough and dyspnea in this patient? (2006)

A 65-year-old woman presented to her primary care physician with a 3-month history of worsening cough, now productive of copious blood-tinged secretions. She also reported a recent onset of fever and dyspnea. She denied any chest pain, chills, night sweats, and weight loss.
Application of density functional theory to infrared absorption intensity calculations on transition-metal carbonyls (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplication of density functional theory to infrared absorption intensity calculations on transition-metal carbonylsLiangyou Fan and Tom ZieglerCite this: J. Phys. Chem. 1992, 96, 17, 6937–6941Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/j100196a016https://doi.org/10.1021/j100196a016research-articleACS PublicationsRequest reuse permissionsArticle Views451Altmetric-Citations195LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Draco-Based Selective Crypto-Compression Method of 3D objects (2022)

3D objects play an essential part in many differ-ent domains. They are considered to be important assets and therefore need to be secured. Sometimes, certain users may have the right to access only a part of the 3D object, for example the shape of the object, but not the content. Recently, selective encryption schemes have been proposed in order to allow this. 3D objects are often stored on the cloud or need to be rendered in real time, and therefore compression is important. In this paper, we propose a selective crypto-compression method for 3D objects. This is based on the Draco compression method, which was developed by Google for 3D objects. Our method is format compliant, and to the best of our knowledge, we are the first to propose a selective cry to-compression method for 3D objects.
TUBE (Text-cUBE) for discovering documentary evidence of associations among entities (2007)

User-driven discovery of associations among entities, and documents that provide evidence for these associations, is an important search task conducted by researchers and do-main information specialists. Entities here refer to real or abstract objects such as people, organizations, ideologies, etc. Associations are the inter-relationships among entities. Most current works in query-driven document retrieval and finding representative subgraphs are ill-suited for the task as they lack an awareness of entity types as well as an intuitive representation of associations. We propose the TUBE model, a text cube approach for discovering associations and documentary evidence of these associations. The model consists of a multi-dimensional view of document data, a flexible representation of multi-document summaries, and a set of operations for data manipulation. We conduct a case study on real-life data to illustrate its applicability to the above task and compare it with the non-TUBE approach.
Thermal emittance mapping of a cesium telluride photocathode using microlens-arrays based laser pattern beam (2019)

The thermal emittance map of the cesium telluride photocathode is measured using a laser pattern beam produced by microlens arrays. A pair of MLAs are employed to produce a periodic transverse pattern beam, consisting of a two-dimensional array of laser beamlets. The laser pattern beam was illuminated onto the cesium telluride cathode to produce an electron pattern beam. The rms beamsize of the electron beamlets is monitored on a YAG screen with different solenoid strengths, and the thermal emittance is fitted by the solenoid scan method. The measured thermal emittances of seven beamlets vary from 0.934 mm mrad/mm to 1.142 mm mrad/mm. The thermal emittance of each beamlet is compared with the quantum efficiency, demonstrating the dependence of the thermal emittance on the quantum efficiency for the cesium telluride photocathode.