gebhart/patrepeval huggingface dataset:
Optical Stark spectroscopy of the $2_0^6$26 $\tilde{A}^1A^{\prime \prime} - \tilde{X}^1A^{\prime} $A1A′′−X1A′ band of chloro-methylene, HCCl (2012)

The laser induced fluorescence spectra of the 2(0)(6)Ã(1)A('')-X̃(1)A(') band of a rotationally cold (<20 K) molecular beam sample of chloro-methylene, HCCl, has been recorded, field-free and in the presence of a static electric field. The field-free spectrum has been analyzed to produce an improved set of spectroscopic parameters for the Ã(1)A('') (060) vibronic state. The magnitude of the a-component of the permanent electric dipole moment, μ(a), for the X̃(1)A(') (000) vibronic state has been determined to be 0.501(1) D from the analysis of the observed electric field induced shifts. Comparisons with theoretical predictions and flouro-methylene, HCF, are presented.
A novel application of white light sensing to dynamic oil film measurement (1995)

Monitoring of the thickness of dynamic oil films is of great interest to engine manufacturers and oil producing companies. The technique described in this paper uses white light interferometery incorporating the channelled spectrum technique, which exhibits an accuracy of ~0.1 ?m and allows absolute distance measurements to be made over approximately 5 mm working range. In order to overcome the zero offset characteristic of white light interferometers, a novel probe design is described that utilises a titanium dioxide coating to improve the reflectance of the fibre end-face. Application to a simulated IC engine connecting rod test rig is performed and the resultant distribution of oil film thickness for given speeds of a rotating shaft are shown
Carbon dioxide‐independent and ‐dependent components of light inhibition of the conversion of 1‐aminocyclopropane‐1‐carboxylic acid to ethylene in oat leaves (1984)

Light inhibits while carbon dioxide enhances the conversion of 1‐aminocyclopropane‐1‐carboxylic acid (ACC) to ethylene in oat ( Avena sativa L. cv. Victory) leaf segments. The possibility that the light inhibition is mediated through changes of carbon dioxide has been investigated. The level of CO 2 increases or decreases in the sealed incubation vial in darkness or in light, respectively, which can apparently account for the differences in ACC‐dependent ethylene production between the dark and light treatments. However, although the evolution of ethylene from ACC in the dark is reduced upon depletion of CO 2 , the difference between light and dark is still very noticeable. Moreover, the production of the ethylene in CO 2 ‐free air in the dark was still higher than in the light, where the concentration of CO 2 was 0.01%. It is proposed that the light effect on the conversion of ACC to ethylene is composed of two distinguishable components: one CO 2 ‐mediated and the other CO 2 ‐independent.
Macrocyclic DNA-encoded chemical libraries: a historical perspective (2021)

While macrocyclic peptides are extensively researched for therapeutically relevant protein targets, DNA-encoded chemical libraries (DELs) are developed at a quick pace to discover novel small molecule binders. The combination of both fields has been explored since 2004 and the number of macrocyclic peptide DELs is steadily increasing. Macrocycles with high affinity and potency were identified for diverse classes of proteins, revealing DEL's huge potential. By giving a historical perspective, we would like to review the methods which permitted the rise of macrocyclic peptide DELs, describe the different DELs which were created and discuss the achievements and challenges of this emerging field.
Dynamics of vibrationally excited ozone formed by three-body recombination. I. Spectroscopy (1987)

Spectrally resolved infrared fluorescence near 10 μm from vibrationally excited O3(ν3) has been observed in a cryogenic reactor facility at low pressure. The excited O3(v) is formed principally by three-body recombination of O and O2 in flowing, microwave-discharged O2/Ar mixtures at 1 Torr and 80 K. The spectral resolution is sufficient to permit identification and assignment of band centers for up to five quanta of stretching excitation. The observed transition frequencies are consistent with those predicted from a Darling–Dennison perturbation treatment. The spectra, which sample the recombination/deactivation sequence in its early to middle stages, indicate surprisingly little intermode coupling, being predominantly ν3 in character. There is also evidence of O3(v) excitation by near-resonant V–V coupling between O3 and O2(v=2). The spectroscopic analysis of the data is described, and considerations for scaling the spontaneous transition probabilities with vibrational level are discussed.
Physical and Functional Interaction between Two Pluripotent Proteins, the Y-box DNA/RNA-binding Factor, YB-1, and the Multivalent Zinc Finger Factor, CTCF (2000)

CTCF is a unique, highly conserved, and ubiquitously expressed 11 zinc finger (ZF) transcriptional factor with multiple DNA site specificities. It is able to bind to varying target sequences to perform different regulatory roles, including promoter activation or repression, creating hormone-responsive gene silencing elements, and functional block of enhancer-promoter interactions. Because different sets of ZFs are utilized to recognize different CTCF target DNA sites, each of the diverse DNA.CTCF complexes might engage different essential protein partners to define distinct functional readouts. To identify such proteins, we developed an affinity chromatography method based on matrix-immobilized purified recombinant CTCF. This approach resulted in isolation of several CTCF protein partners. One of these was identified as the multifunctional Y-box DNA/RNA-binding factor, YB-1, known to be involved in transcription, replication, and RNA processing. We examined CTCF/YB-1 interaction by reciprocal immunoprecipitation experiments with anti-CTCF and anti-YB-1 antibodies, and found that CTCF and YB-1 form complexes in vivo. We show that the bacterially expressed ZF domain of CTCF is fully sufficient to retain YB-1 in vitro. To assess possible functional significance of CTCF/YB-1 binding, we employed the very first identified by us, negatively regulated, target for CTCF (c-myc oncogene promoter) as a model in co-transfection assays with both CTCF and YB-1 expression vectors. Although expression of YB-1 alone had no effect, co-expression with CTCF resulted in a marked enhancement of CTCF-driven c-myc transcriptional repression. Thus our findings demonstrate, for the first time, the biological relevance of the CTCF/YB-1 interaction.
Lower Apo A-I and Lower HDL-C Levels Are Associated With Higher Intermediate CD14 ++ CD16 + Monocyte Counts That Predict Cardiovascular Events in Chronic Kidney Disease (2014)

Taken together, mediators of cholesterol efflux are associated with CD14(++)CD16(+) monocyte counts, which independently predict adverse outcome in CKD.
Inhibition of tumor growth in a human neuroblastoma xenograft model with TNP-470 (2000)

These data show that TNP-470 is a potent inhibitor of human neuroblastoma growth both alone and when given with conventional chemotherapy, suggesting that it may be a useful adjunctive therapy for high-risk neuroblastoma patients.
Six of 12 relapsed/refractory indolent lymphoma patients treated 10 years ago with tositumomab and 131I-tositumomab remain in complete remission (2011)

356 Objectives Advanced stage indolent non-Hodgkin’s lymphoma (NHL) cannot be cured by conventional therapy while localized stage I/II disease may be cured by radiotherapy as suggested by very low recurrence rates observed after 10 years progression free survival (J Clin Oncol 1996;14:1282). Methods Over 9 years ago, we treated in Switzerland 12 indolent and 4 transformed, relapsed/refractory lymphoma patients with a single, non-myeloablative therapy of tositumomab and 131I-tositumomab (Bexxar) in a GlaxoSmithKline open-label phase II study. The 16 patients had a mean of 3.1 (range 1 to 6) prior chemotherapy/antibody treatments. Results Three of four transformed lymphomas progressed after Bexxar and only 1 patient had a partial response lasting 10 months. All 12 patients with recurrent indolent lymphoma responded, 4 (33%) with partial and 8 (67 %) with complete remission (CR/CRu). Side effects were mostly mild and transient except for 1 patient who developed a myelodysplastic syndrome 34 months after RIT and 74 months after initial diagnosis and treatment with CHOP. Six of the 8 CR/CRu patients remain disease free a mean of 9.8 years (range 8.6-10.7) after radioimmunotherapy. Conclusions Our results show that long lasting complete remissions were observed after a single course of radioimmunotherapy in half of the patients with recurrent indolent lymphoma after 1-6 prior chemo- and/or immunotherapies. Research Support Swiss Cancer League (KFS 991-02-2000
Clinical characteristics and outcomes of patients with prostate cancer and parenchymal brain metastases (PBM). (2014)

187 Background: Parenchymal brain metastases' (PBM's) are rare in prostate cancer (PCa), but the introduction of novel therapies that prolong life for metastatic disease has raised the possibility that the distribution of disease may be changing as patients live longer. In an effort to establish the clinical characteristics and outcomes of PBM as a comparator for future studies, we reviewed all cases at our institution over a 13 year period. Methods: Patients (pts) diagnosed with PBM at Memorial Sloan-Kettering Cancer Center between 2000 and 2010 were retrospectively identified by billing codes for prostate cancer, brain metastases, and no additional primary cancers. Additional cases since 2010 were manually collected prospectively. Direct extension of osseous skull metastases or leptomeningeal disease were not considered PBM. Demographic, clinical, and pathologic characteristics were recorded. Results: 5,474 pts with metastatic PCa and no other primary malignancy were identified of whom 21 had PBM. An additional four PBM cases were prospectively identified, for a total of 25 pts. Twenty two pts (88%) had prostate adenocarcinoma (adeno), of which 14 had Gleason 8 or more disease, 20 had castration resistant disease, and nine had prostate-specific antigen (PSA) less than 5ng/mL. The other three (12%) had atypical histologies (osteosarcoma, small cell carcinoma, and high grade neuroendocrine carcinoma). Median time from diagnosis of PCa to diagnosis of PBM was 3.7 years (range 0 to 19.8) and from discovery of metastatic PCa to PBM was 2.3 years (range 0 to 10). At the time of PBM diagnosis all pts had 1 or more additional site of disease - bone metastases in 20 (80%), lung in 13 (52%), liver in nine (36%). Treatments included whole brain RT in 10 (45%), surgery +/- RT in 8 (36%) and stereotactic RT in 2 (9%). Median overall survival from diagnosis of PBM was 4.3 months (0.7-18.1) in adeno pts compared with 0.7 months (0.7-1.0) in atypical histology pts. Only four pts (16%) survived 12 or more months. Conclusions: In this contemporary cohort, PBM cases were often associated with PCa of atypical histology, high Gleason grade, frequent visceral disease, and low PSA production. Survival was poor after diagnosis of PBM despite treatment. These data can be used as a comparator to track whether treatment with novel PCa therapies is altering the incidence and characteristics of CNS involvement.
Caenorhabditis elegans in Chinese Medicinal Studies: Making the Case for Aging and Neurodegeneration (2013)

Aging is a progressive process with degenerative changes of various tissues and organs. As a classic model organism in genetics and neurobiology, Caenorhabditis elegans is also a powerful system in aging and behavioral studies and can be used at both the molecular and organismal levels to evaluate potential therapeutics for age-related neurodegeneration, owing to its short life span, relative simplicity, and high degree of experimental tractability as well as significant conservation of disease genes and signaling pathways with humans. We attempt here to summarize the use of C. elegans models in exploring traditional Chinese medicine for potential remedies against aging and neurodegeneration.
Epidermoid Cyst Occurring Within an Intrapancreatic Accessory Spleen. A Case Report and Review of the Literature (2015)

Epidermoid cysts occurring within intrapancreatic accessory spleens can mimic a malignant process both clinically and radiographically. Surgery with pathologic assessment is the only reliable means of diagnosis. While they are a very rare entity, it is an important component of a complete differential diagnosis for a patient presenting with a pancreatic tail mass.
Regiochemical control of the ring opening of 1,2-epoxides by means of chelating processes. 5. Synthesis and reactions of some 2,3-epoxy-1-alkanol derivatives (1993)

In order to study the effect of a remote polar functionality on the regiochemistry of the ring opening of aliphatic epoxides, the synthesis and some nucleophilic additions (methanolysis, azidolysis, and aminolysis) of suitable 2,3-epoxy-1-alkanol derivatives (epoxides trans-1a-d and cis-2) were carried out. The C-3 selectivity commonly observed when nonchelating ring opening conditions are used is lower than when the epoxides are allowed to react in the presence of metal ions (Li+, Mg2+, Zn2+) due to the probable intervention of bidentate-chelated intermediates in the latter case, and in some instances an almost complete C-3 regioselection is obtained. Under identical conditions involving chelation control, trans epoxide la shows higher C-3 selectivity than cis isomer 2. A free hydroxyl functionality is not necessary in order to observe chelation-controlled regioselectivity in the epoxides that we examined.
miR-579-3p controls melanoma progression and resistance to target therapy (2016)

Therapy of melanoma patients harboring activating mutations in the BRAF (V-raf murine sarcoma viral oncogene homolog B1) oncogene with a combination of BRAF and MEK inhibitors is plagued by the development of drug resistance. Mutational events, as well as adaptive mechanisms, contribute to the development of drug resistance. In this context we uncover here the role of a miRNA, miR-579-3p. We first show that low expression of miR-579-3p is a negative prognostic factor correlating with poor survival. Expression levels of miR-579-3p decrease from nevi to stage III/IV melanoma samples and even further in cell lines resistant to BRAF/MEK inhibitors. Mechanistically, we demonstrate that miR-579-3p acts as an oncosuppressor by targeting the 3'UTR of two oncoproteins: BRAF and an E3 ubiquitin protein ligase, MDM2. Moreover miR-579-3p ectopic expression impairs the establishment of drug resistance in human melanoma cells. Finally, miR-579-3p is strongly down-regulated in matched tumor samples from patients before and after the development of resistance to targeted therapies.
SISCONTROL: sistema de controle digital de temperatura para forno de solda BGA e SMD (2013)

Este documento aborda o desenvolvimento de um projeto de controle digital de temperatura para um forno para ser utilizado como ferramenta de solda para circuitos eletronicos. A interface fisica do projeto e composta por tres modulos: digital, controle e forno. O modulo digital e responsavel por todo o processamento do sistema. E atraves dessa interface que o usuario fara a interacao com o projeto. O modulo de controle sera o responsavel por chavear a tensao da rede eletrica para o forno atraves de um PWM (Pulse-Width Modulation) gerado pelo modulo digital. O ultimo modulo e o responsavel pelo aquecimento. Trata-se de um forno de uso domestico devidamente adaptado para ser utilizado para tal finalidade.
A Framework of Interface Improvements for Designing New User Interfaces for the MANUS Robot Arm (2005)

Users of the MANUS robot arm experience a high cognitive and physical load when performing activities of daily living with the arm. These high loads originate from user interface problems and limitations. To reduce these high loads the user interface of the MANUS needs to be improved. Because large differences exist between the residual capabilities of MANUS users, different user interfaces need to be developed. As a design aid, a framework with user interface improvements and new features was developed. With this framework several new user interfaces can be designed. Most interface features in the framework can be adjusted to the residual body functions of the users and thereby reduce the high loads that users experience.
Polylithiumkomplexe aus phenylsubstituierten 1,6,6aλ4‐Trithiapentalenen und verwandten Verbindungen und Lithium (1984)

Abstract Phenylsubstituierte 1,6,6aλ 4 ‐Trithiapentalene ( 1a – d ) und 3 H ‐1,2‐Dithiol‐3‐thione ( 2a , b ), 2‐(4‐Phenyl‐3 H ‐1,2‐dithiol‐3‐yliden)acetophenon ( 3 ) und 1,5‐Diphenyl‐1,3,5‐pentantrion ( 4 ) reagieren in Tetrahydrofuran oder 2‐Methyltetrahydrofuran bei 0°C mit 7 – 10 Li/mol zu hochreaktiven, löslichen Polylithiumkomplexen, die durch Ausfällung mit Pentan als Feststoffe der Zusammensetzung ALi 7–10 · THF, A = Ausgangsverbindung, isoliert werden können. Für den aus 1a und 10 Li in THF erhältlichen Polylithiumkomplex wurde aufgrund der Reaktion mit Wasser bzw. Methyliodid, Pentacen und Wasserstoff die Konstitution 5a vorgeschlagen. Die Annahme, daß in 5a und in dem vergleichbaren Komplex 5b (aus 1b und 9 Li) Li 2 S‐Moleküle komplexgebunden sind, wird insbesondere durch 7 Li‐ und 1 H‐NMR‐Messungen an festem 5b unterstützt.
Effect of Drying Medium on Residual Moisture Content and Viability of Freeze-Dried Lactic Acid Bacteria (1985)

The effect of various substances on the relationship between residual moisture content and the viability of freeze-dried lactic acid bacteria has been studied. Compounds such as polymers, which display considerable ability in displacing water, showed no protective action during freeze-drying. Adonitol, on the other hand, produced the smallest change in water content at various times during drying and allowed the highest rate of survival.
Efficient modeling of virtual humans in MPEG-4 (2002)

This and the accompanying paper present an overview of the face and body animation object in the MPEG-4 Version 2 standard. The MPEG-4 standard includes the representation, compression of virtual human models and their interface with other MPEG-4 objects, with bit rate requirements as low as 1 Kbit/second. In this paper we give an overview of geometrical modeling techniques for the FBA object, and in the accompanying paper we describe the animation techniques.
NEAR INFRARED SPECTROSCOPY (NIRS); MATHEMATICAL MODELING OF DETRUSOR HAEMOGLOBIN CONCENTRATION AND URODYNAMIC PRESSURES IN WOMEN (2008)

You have accessJournal of Urology1 Apr 2008NEAR INFRARED SPECTROSCOPY (NIRS); MATHEMATICAL MODELING OF DETRUSOR HAEMOGLOBIN CONCENTRATION AND URODYNAMIC PRESSURES IN WOMEN Lynn Stothers, and Andrew Macnab Lynn StothersLynn Stothers More articles by this author , and Andrew MacnabAndrew Macnab More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)61526-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "NEAR INFRARED SPECTROSCOPY (NIRS); MATHEMATICAL MODELING OF DETRUSOR HAEMOGLOBIN CONCENTRATION AND URODYNAMIC PRESSURES IN WOMEN." The Journal of Urology, 179(4S), p. 517 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 517 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Lynn Stothers More articles by this author Andrew Macnab More articles by this author Expand All Advertisement PDF DownloadLoading ...
Unraveling the genetic diversity of Belgian Milk Sheep using medium‐density SNP genotypes (2019)

The present study focuses on the Belgian Milk Sheep in Flanders (Belgium) and compares its genetic diversity and relationship with the Flemish Sheep, the Friesian Milk Sheep, the French Lacaune dairy sheep and other Northern European breeds. For this study, 94 Belgian Milk Sheep, 23 Flemish Sheep and 22 Friesian Milk Sheep were genotyped with the OvineSNP50 array. In addition, 29 unregistered animals phenotypically similar to Belgian Milk Sheep were genotyped using the 15K ISGC chip. Both Belgian and Friesian Milk Sheep as well as the East Friesian Sheep were found to be less diverse than the other seven breeds included in this study. Genomic inbreeding coefficients based on runs of homozygosity (ROH) were estimated at 14.5, 12.4 and 10.2% for Belgian Milk Sheep, Flemish Sheep and Friesian Milk Sheep respectively. Out of 29 unregistered Belgian Milk Sheep, 28 mapped in the registered Belgian Milk Sheep population. Ancestry analysis, PCA and F<sub>ST</sub> calculations showed that Belgian Milk Sheep are more related to Friesian Milk Sheep than to Flemish Sheep, which was contrary to the breeders' expectations. Consequently, breeders may prefer to crossbreed Belgian Milk Sheep with Friesian sheep populations (Friesian Milk Sheep or East Friesian Sheep) in order to increase diversity. This research underlines the usefulness of SNP chip genotyping and ROH analyses for monitoring genetic diversity and studying genetic links in small livestock populations, profiting from internationally available genotypes. As assessment of genetic diversity is vital for long-term breed survival, these results will aid flockbooks to preserve genetic diversity.
InteractoMIX: a suite of computational tools to exploit interactomes in biological and clinical research (2016)

Virtually all the biological processes that occur inside or outside cells are mediated by protein-protein interactions (PPIs). Hence, the charting and description of the PPI network, initially in organisms, the interactome, but more recently in specific tissues, is essential to fully understand cellular processes both in health and disease. The study of PPIs is also at the heart of renewed efforts in the medical and biotechnological arena in the quest of new therapeutic targets and drugs. Here, we present a mini review of 11 computational tools and resources tools developed by us to address different aspects of PPIs: from interactome level to their atomic 3D structural details. We provided details on each specific resource, aims and purpose and compare with equivalent tools in the literature. All the tools are presented in a centralized, one-stop, web site: InteractoMIX (http://interactomix.com).
Role of Deep Learning in Medical Image Super-Resolution (2022)

Recently, deep learning-based convolutional neural networks method for image super-resolution has achieved remarkable performance in various fields including security surveillance, satellite imaging, and medical image enhancement. Although these approaches obtained improved performance in medical images, existing works only used a pre-processing step and hand-designed filter methods to improve the quality of medical images. Pre-processing step and hand-designed-based reconstructed medical image results are very blurry and introduce new noises in the images. Due to this, sometimes medical practitioners make wrong decisions, which are very dangerous for human beings. In this chapter, the authors explain that the hand-designed as well as deep learning-based approaches, including some image quality assessment metrics to open the gate to verify the images with different approaches, depend on the single image approach. Furthermore, they discuss some important types of medical images and their properties.
ChemInform Abstract: A Catalytic and Stereoselective Glycosylation with Glucopyranosyl Fluoride by Using Various Protic Acids. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.