gebhart/patrepeval huggingface dataset:
Abstract P2106: Arrhythmia As Cause For The Development Of The Takotsubo Syndrome In A Patient-specific Atrial Stem Cell Model (2022)

Background and Aims: The Takotsubo syndrome (TTS) is characterised by an acute left ventricular dysfunction without exhibiting signs of stenosis. TTS affects mainly the left ventricle, however, its pathophysiology comprises transient impairments in left atrium functions with a prevalence of atrial fibrillation (AF) of around 18% correlating with higher ventricular heart rhythm disorders. In this study, we aimed to prove the hypothesis that molecular and cellular arrhythmic events contribute to the development of TTS under catecholamine stress and to test if the currently clinically used β-blockers (Metoprolol) are suitable for Takotsubo cardiomyopathy in vitro. Methods and Results: We generated induced pluripotent stem cell-derived atrial cardiomyocytes (TTS-iPSC- a CMs) from TTS patients, confirmed atrial marker expression (MLC2a, PItX2, NR2F2), and treated the cells with catecholamines to mimic TTS-phenotype. Using a cytosolic Förster resonance energy transfer (FRET) based cAMP sensor, we tested the activity of phosphodiesterases (PDEs) in TTS-iPSC-aCMs, which are besides β-ARs main players involved in cAMP signaling in CMs. We observed that after β-AR stimulation, the strong effects of the PDE4 family in the cytosol of atrial controls were significantly decreased in aCMs of the TTS patients. This effect was completely rescued after application of PDE4 activator MR-L2 and is in line with the previously described downregulation of PDE4 in human atrial myocardium of AF patients. In functional studies, isoprenaline-induced increase in systolic Ca 2+ transient amplitude was more pronounced in TTS iPSC-aCM compared to controls. These effects were rescued by both, the clinically approved β-blocker Metoprolol as well as the PDE4 activator MR-L2. To analyse arrhythmic events in atrial TTS CMs, we performed confocal Ca 2+ measurements and demonstrated that the diastolic sarcoplasmic reticulum Ca 2+ leak was increased in iPSC aCMs of TTS patients compared to control under basal conditions and after Iso-treatment. In addition, TTS patients displayed faster Ca 2+ kinetics compared to control cells, already under basal conditions. These results were underlined on a molecular level by increased phospholamban phosphorylation in TTS iPSC-aCM .Subsequent treatment with the beta-blocker Metoprolol rescued the Ca 2+ kinetic parameters in all cell lines. Conclusion: In conclusion, we were able to draw a comprehensive picture on the role of the arrhythmia in the development of TTS. We found TTS-specific differences with reduced PDE4 activity, elevated arrhythmic events and enhanced reactions to catecholamines, which could be rescued by the clinically approved drug Metoprolol and partly by the PDE4 activator MR-L2. Therefore, Metoprolol as well as MR-L2 demonstrate promising effects as patient-specific therapeutic target for TTS.
The “Do-it-yourself (DIY)” brand design strategy through computational design tools (2022)

The three-dimensional form of a product is a key element in the development of a brand identity through the computational design methodology. Brand identity has an in-depth relationship with the object’s shape and product assembliness. In traditional mass production design methodologies, designers encode specific parameters into design rules that aren’t used by end-users to customize their own products. The “Do-It-Yourself (DIY)” process enable users to express themselves through the design thinking approach. Self-design is a form of co-creation between designer's knowledge and customer's skills according to the branded product design parameters. Under this statement, the object’s geometrical form and the product assembliness are fundamental principles in the promotion of a holistic design identity to the industry and to the market. The current paper combines the use of computational design with specific parameters of DIY bookcase/desk (i.e., height, length, width, number of shelves, etc.) in order to develop a generative design system for the mass customization of DIY bookcases/desks alternatives. The results from the end-user application offer, automatically alternatives 3D models under the "Do-It-Yourself" brand umbrella.
Immunologic studies of patients with histoplasmosis. (1979)

Immunologic responses of patients with active histoplasmosis (Group I) were compared to the responses of healthy persons with positive histoplasmin skin-test reactions (Group II), and to those of healthy persons with negative histoplasmin skin-test reactions (Group III). Cellular immune responses were significantly depressed in patients. Seven (54 per cent) of 13 patients failed to respond to histoplasmin skin testing, and two (15 per cent) failed to respond to skin-test antigens unrelated to Histoplasma capsulatum. Lymphocyte transformation (LT) responses of patients were severely depressed in vitro (p less than 0.001) to Histoplasma antigens when compared to the responses of healthy, histoplasmin-reactive donors. Transformation responses to Candida antigen were not impaired in the patient population. Culturing lymphocytes of patients in serum obtained from healthy donors as opposed to autologous serum resulted in a significant (p less than 0.05) increase in LT responses to H. capsulatum. Responses to Candida antigen and to mitogens were not affected by the serum source. Serum-mediated suppression of LT responses correlated (p less than 0.01) with complement-fixing antibody titers to Histoplasma yeast-phase antigen and suggests that antibody, either alone or complexed with antigen, may suppress T-cell response in vitro in this disease.
SWeeT: Security Protocol for Wearables Embedded Devices’ Data Transmission (2022)

Motivated by the quest for decreased healthcare costs and further fueled by the COVID pandemic, wearable devices have gained major attention in recent years. Yet, their secure usage and patients’ privacy continue to be concerning. To address these issues, the paper presents SWeeT, a novel lightweight protocol for allowing flexible and secure access to the collected data by multiple caregivers while sustaining the patient’s privacy. Particularly, SWeeT deploys Physically Unclonabale Functions (PUFs) to generate encryption keys to safeguard the patients’ data during transmission. The computation overhead is significantly reduced by applying very simple encryption operations while enabling frequent change of the keys to sustain robustness. SWeeT is shown to counter impersonation, Sybil, man-in-the-middle, and forgery attacks. SweeT is validated through experiments using implementation on an Artix7 FPGA and through formal security analysis.
Efficacy of enrofloxacin or doxycycline for treatment of Bartonella henselae or Bartonella clarridgeiae infection in cats (1997)

Enrofloxacin and doxycycline are antimicrobial agents used to treat bacterial diseases of cats. In vitro susceptibility data indicate that either drug should be effective against Bartonella species. In vivo efficacies of these drugs for eradication of chronic Bartonella henselae or Bartonella clarridgeiae infections were examined in 18 experimentally infected cats and 25 naturally exposed cats treated with enrofloxacin (22.7 mg given orally [PO] every 12 h [q12h] [14 days, n = 10; 28 days, n = 13]) or with doxycycline (25 mg PO q12h [14 days, n = 9; 28 days, n = 8]) or not treated (n = 3). Plasma drug concentrations were determined in experimental cats by high-performance liquid chromatography. Only 23 of 43 cats enrolled ultimately met inclusion criteria. Bacteremia was eliminated for 12 to 25 weeks posttreatment in four of seven cats receiving 14 days of enrofloxacin, five of seven cats receiving 28 days of enrofloxacin, one of six cats receiving 14 days of doxycycline, and one of two cats receiving 28 days of doxycycline. Defining a negative result by blood culture as treatment success may be erroneous; these results may reflect the insensitivity of blood culture or the relapsing nature of Bartonella bacteremia. Our results suggest that MICs obtained with axenic media do not predict antimicrobial activity against intracellular Bartonella, that a long treatment course is required to eliminate infection, and that duration of therapy correlates with pretreatment bacterial load. Given current concern about the development of antimicrobial resistance, we would reserve recommendation for treatment to cats owned by an immunocompromised individual or as an alternative to euthanasia of a pet.
Asymmetric Synthesis of β-Nitro Ketones via Michael Addition of Lithiated α-Amino Nitriles to Nitroalkenes (2008)

Alpha-amino nitriles, easily prepared from aldehydes, KCN, and an enantiopure secondary amine auxiliary, are metalated and used as nucleophiles in asymmetric Michael additions to nitroalkenes to afford the Michael adducts in good yields and good to excellent diastereoselectivities. After chromatographic purification, the diastereomerically pure 1,4-adducts are cleaved under acidic conditions to give the beta-nitro ketones in good yields and with two exceptions in good to excellent enantiomeric excesses (ee = 86-99%). The absolute configuration was determined by X-ray structure analysis.
"Proud disturber of thy country's peace" - Reading Social and Political Dissidence in Christopher Marlowe's Edward II (2013)

Tarkastelen tässä pro gradu -tutkielmassa Christopher Marlowen näytelmää Edward II (n. 1594) yhteiskunnallisesti radikaalina oman aikansa teoksena. Pyrin osoittamaan, että Marlowen näytelmä haastaa aikansa dominantteja käsityksiä poliittisista ja sosiaalisista ilmiöistä. Siinä missä Elizabethin ajan hallinto pyrki ylläpitämään yhteiskunnallista järjestystä välittämällä kansalaisilleen providentialistista maailmankuvaa, viime vuosikymmenten materialistinen kirjallisuuskritiikki on painottanut renessanssin ajan teatterin ja draaman roolia tämän ideologian vastustajana.\n\nKäsittelen tutkielmassani Edward II:n radikaalisuutta useilla eri osa-alueilla. Edward II:sta puuttuu paitsi omalle ajalleen ominainen providentialistinen maailmankuva, mutta se myös kuvaa Englannin epävakaana ja jakaantuneena kansakuntana vastoin hallinnon ylläpitämää harmonista mielikuvaa pimeän keskiajan jälkeisestä poliittisesti vakaasta valtiosta. Lisäksi näytelmässä hovi esitetään vailla hierarkiaa ja teatraalisuutta, jotka olivat keskeisiä tekijöitä hallitsijan vallan ylläpitämisessä 1500-luvun Englannissa.\n\nToisaalta Marlowe käyttää hyväkseen myös renessanssin teatterin ideologista voimaa, sillä teatterissa myös kuningas voitiin asettaa tarkkailun alaiseksi, mikä mahdollisti esityksestä maksaneelle yleisölle tietyn autonomisen roolin hallitsijan arvostelijoina. Esittämällä Kuningas Edwardin sodomiittisen suhteen hyväksyttävänä, kyseenalaistamalla tämän pätevyyden hallitsijana sekä paljastamalla tämän salamurhan häikäilemättömänä poliittisena hirmutekona vailla moraalisia opetuksia Marlowe kritisoi hyveellisen hallitsijan ympärille muodostettua illuusiota. Tämän lisäksi tulee huomioida, että historianäytelmänä Edward II ymmärrettiin ajankohtaisen poliittisen ilmapiirin allegoriana eikä ainoastaan historiallisten tapahtumien kuvauksena.\n\nTutkielmani teoreettinen viitekehys sijoittuu kulttuurimaterialismin, uushistorismin ja marxismin alueille. Tutkimukseni keskeisimpiä kulttuurimaterialistisia kriitikoita ovat Raymond Williams, Jonathan Dollimore ja Alan Sinfield sekä uushistorismin puolelta Stephen Greenblatt ja Louis Montrose. Kulttuurimaterialistinen kirjallisuudentutkimus on pyrkinyt paikantamaan renessanssin ajan teoksista toisinajattelua, kun taas uushistorismi on usein tyytynyt esittämään tämän toisinajattelun ainoastaan vallitsevaa hegemoniaa voimistavana. Tavoitteenani on kuitenkin osoittaa, että teatterilla oli erityinen ideologinen asema Elizabethin ajan Englannissa, mikä teki siitä yhteiskunnallisesti merkittävän instituution. Tämä erityisasema on havaittavissa myös Marlowen näytelmässä.\n\nAsiasanat:Marlowe, Christopher, kulttuurimaterialismi, uushistorismi, marxismi, ideologia, hegemonia, providentialismi
Effects of electropulsing on microstructure and conductivity of nanofilms of Zn-Al alloys (2012)

Nanotechnology 2012: Advanced Materials, CNTs, Particles, Films and Composites - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012, Santa Clara, CA, 18-21 June 2012
Design of a recursively-structured valveless device for microfluidic manipulation (2003)

A recursively-structured apparatus based on a pneumatic pumping structure has been investigated numerically and experimentally in the present study. For the T-connected channels, this apparatus demonstrated the ability to manipulate the liquid drop from a first channel to a second channel, while simultaneously preventing flow into the third channel. The microTAS research aimed at biochemical analysis miniaturization and integration has recently made explosive progress. However, there is still a considerable technical challenge in integrating these procedures into a multiple-step system. An important issue for this integration is microfluid management techniques. The microTAS method must be designed considering special transport mechanisms to move samples and reagents through the microchannels. The structure of this apparatus was simple and easily fabricated. Moreover, because there is a continuous airflow at the "outlet" during fluid manipulation, it is possible to avoid contamination of the air source similar to the "laminar flow hook" in biological experiments. Utilizing the concept of a recursive structure, one can easily design a device wherein more than three channels are included in the flow network, either intersecting in a single junction or in multiple junctions.
Characterization through global hybrid simulations of solar wind ions impacting the dayside of Mercury (2014)

It has long been suspected since Mariner-10 observations that solar wind ions could reach the surface of Mercury: Kallio & Janhunen (2003) and Travnicek et al (2010) have presented simulated maps of precipitating proton fluxes. Attempts to refine estimations of precipitating fluxes of solar wind ions are important as these precipitations create additional sources of exospheric and possibly magnetospheric populations, and as their space-weathering effects modify the properties of the regolith. We run the global hybrid model used by Richer et al. (2012) which takes self-consistently into account the alpha particles of the solar wind to estimate fluxes of solar wind protons and alphas impacting the surface of Mercury under different IMF conditions. The internal source of the Hermean magnetic field is axisymmetric and is the superposition of a dipole and a quadrupole consistent with MESSENGER observations (Anderson et al., 2011) as in Richer et al. (2012). Results are briefly compared to predictions made with the offset dipole model of the planetary field. New simulations, made with an improved spatial resolution of 40km, reveal important differences between proton and alpha fluxes and show large variations with interplanetary conditions. In a first step we investigate the properties of solar wind ions impacting the dayside of the planet, precipitations on the night side will be examined later in a second step. References Anderson et al., Science, 333 , 1859, (2011) Kallio, E., and P. Janhunen, Solar wind and magnetospheric ion impact on Mercury's surface, Geophys. Res. Lett., 30(17), 1877, doi:10.1029/2003GL017842, 2003. Travnicek, P.M., D. Schriver, P. Hellinger, D. Hercik, B.J. Anderson, M. Sarantos, and J.A.Slavin, Mercury's magnetosphere-solar wind interaction for northward and southward interplanetary magnetic field: Hybrid simulation results, Icarus, doi:10.1016/j.icarus.2010.01.008, 2010 Richer, E., R. Modolo, G. M. Chanteur, S. Hess, and F. Leblanc (2012), A global hybrid model for Mercury's interaction with the solar wind: Case study of the dipole representation, J. Geophys. Res., 117, A10228, doi:10.1029/2012JA017898.
Un modello informativo parametrico per il Duomo di Milano - Test e sperimentazioni (2016)

Nowadays, with the spread of the BIM technology in the Cultural Heritage field, it is important to find, case by case, a method that permits to manage the archeological and architectural artifacts considering their personal needs. &#13;\nIn this case, the project focuses on a portion of the roofs of the Milan Cathedral, chosen for the complexity and richness in shapes of the components, which leads to difficult survey operations. The target was to experience complex methods of multi-sensor and multi-scale data acquisition and to build an infographic three-dimensional reality-based model in order to help and manage the conservation activities of the building. The complexity of the Cathedral’s late gothic style represents a hard challenge for the application of the innovative surveying methods and for modelling with a BIM-oriented software.&#13;\nFor this reason, the experiment was made with two different modelling methods (one is object-oriented modelling BIM and the other is based on the use of NURBS surfaces), in order to find the differences between the two, in terms of managing the survey data, modelling, the accuracy of the model, the time required to create it and the typology of data that they are able to visualize and insert.&#13;\nThe result of this work is an example of methodological approach that can enhance the widespread application of this innovative technology for restoration or maintenance activities of built heritage.
Synthesis of gold-decorated latexes via conducting polymer redox templates (2001)

The efficient electroless deposition of gold from aqueous solutions has been achieved via redox interaction between Au(III) ions and conducting polymers such polypyrrole, polyaniline and poly(3,4-ethylenedioxythiophene). When using the doped, conductive bulk powder forms of these polymers, the average size of the gold deposits decreased from ca. 10 to ca. 1 µm as the initial pH of the reaction solution was increased from pH 0 to 7. In experiments conducted at neutral pH, pH drift down to pH 3 occurred during the redox reaction. However, if the base-treated, non-conductive forms of the polymers were added to AuCl3 solutions at pH 7, the solution pH remained close to neutral, and finely dispersed gold deposits of 100–400 nm were obtained, strongly suggesting that the gold nucleation is pH-dependent. These findings were then used in attempts to prepare gold-clad latex particles by using micrometer-sized, conducting polymer-coated polystyrene latexes as redox templates for the reduction of gold from solution. Although it was not possible to obtain homogeneous gold coatings, a series of latex particles randomly decorated with 40–60 nm gold nanoparticles was obtained, with gold loadings of up to 12.5 wt% as measured by TGA. XPS studies confirmed the presence of metallic gold at the latex surface, in addition to an increase in the oxidation state of the conducting polymer overlayer, thus confirming that a redox interaction had indeed occurred. Disk centrifuge studies clearly indicated a marked decrease in the colloidal stability of the latexes after gold decoration. Finally, pressed pellet solid-state conductivity measurements showed the composite particles to be non-conductive, which is no doubt due to the discrete, well-sepa0rated nature of the gold nanoparticles on the latex, which prevents efficient charge transport.
Burch Colposuspension versus Fascial Sling to Reduce Urinary Stress Incontinence (2007)

The autologous fascial sling results in a higher rate of successful treatment of stress incontinence but also greater morbidity than the Burch colposuspension. (ClinicalTrials.gov number, NCT00064662 [ClinicalTrials.gov] .).
Packaging of printed-circuit lines and its danger for narrow pulse distortion (2002)

We report here a new behavioral feature of a narrow pulse transmitted on a coplanar waveguide (CPW), putting the special stress on the effects caused by the packaging of such a waveguide. An explanation based on the power-leakage effect leads to a clear physical understanding of why such features necessarily appear.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Expression of B7–1, B7–2, and Interleukin–12 in Anti–Fas Antibody–Induced Pulmonary Fibrosis in Mice (1999)

These findings indicate that the T-cell-mediated immune response in this model involved the upregulation of B7-1, B7-2, and IL-12, and that the aberrant expression of B7-1 in bronchiolar epithelial cells may induce autoreactive T cell proliferation against themselves.
JUAN M. LOPE BLANCH, Cuestiones de filología española , México, Universidad Nacional Autónoma de México, 2005 (2011)

JUAN M. LOPE BLANCH,  Cuestiones de filologia espanola , Mexico, Universidad Nacional Autonoma de Mexico, 2005; 324 pp. Jose Joaquin Montes Giraldo
Establishment of a rapid method to quantify eight flavonol glycosides for quality assessment of red toon using UPLC (2017)

Red Toon is a popular vegetable of favorable health benefits over Asia and Russia regions. In this study, isolation and identification of chemical constituents were performed to assess the quality of this functional food cultivated in various origins or harvested in different months. As a result, eight flavonol glycosides including rutin ( I ), myricitrin ( II ), quercetin-3- O - β - d -galactoranoside ( III ), quercetin-3- O - β - d -glucopyranose ( IV ), quercetin-3- O - α - l -arabinopyranoside ( V ), astragalin ( VI ), quercetin-3- O - α - l -rhamopyranoside ( VII ), and kaempferol-3- O - α - l -rhamopyranoside ( VIII ) were obtained. Among these, compounds III and V were isolated from Toona genus for the first time. Importantly, a rapid and convenient ultra-performance liquid chromatography (UPLC) method was developed to quantify the flavonol glycosides in Red Toon and validated for linearity, precision, stability, repeatability, and accuracy successively. In addition, it was found that total flavonoid glycosides (about 2.6%) in the food were kept at a higher level from April to June than other months of the year. Furthermore, their content in the Red Toon collected from ten different origins was also determined and compared, and the results suggested that the total flavonoid glycosides from Shandong Yantai were the highest, followed by Shandong Ximou, supporting a well-recognized viewpoint that Red Toon cultivated in Shandong Province, China, is considered genuine due to the best health benefits and flavor.
Notch Signaling Drives Stemness and Tumorigenicity of Esophageal Adenocarcinoma (2014)

Esophageal adenocarcinoma ranks sixth in cancer mortality in the world and its incidence has risen dramatically in the Western population over the last decades. Data presented herein strongly suggest that Notch signaling is critical for esophageal adenocarcinoma and underlies resistance to chemotherapy. We present evidence that Notch signaling drives a cancer stem cell phenotype by regulating genes that establish stemness. Using patient-derived xenograft models, we demonstrate that inhibition of Notch by gamma-secretase inhibitors (GSI) is efficacious in downsizing tumor growth. Moreover, we demonstrate that Notch activity in a patient's ultrasound-assisted endoscopic-derived biopsy might predict outcome to chemotherapy. Therefore, this study provides a proof of concept that inhibition of Notch activity will have efficacy in treating esophageal adenocarcinoma, offering a rationale to lay the foundation for a clinical trial to evaluate the efficacy of GSI in esophageal adenocarcinoma treatment.
ChemInform Abstract: DEHYDROGENATIVE VACUUM PYROLYSIS: A NOVEL SYNTHETIC TECHNIQUE. CONVERSION OF CYCLOOCTA‐1,5‐DIENE INTO STYRENE AND RELATED REACTIONS (1983)

Abstract Durch Vakuumpyrolyse in Gegenwart von Palladiumkohle werden die Carbonsäureanhydride (I), (III) und (IV) in Phthalsäureanhydrid (II) umgewandelt.