gebhart/patrepeval huggingface dataset:
Human skin pigmentation: melanocytes modulate skin color in response to stress (2007)

All organisms, from simple invertebrates to complex human beings, exist in different colors and patterns, which arise from the unique distribution of pigments throughout the body. Pigmentation is highly heritable, being regulated by genetic, environmental, and endocrine factors that modulate the amount, type, and distribution of melanins in the skin, hair, and eyes. In addition to its roles in camouflage, heat regulation, and cosmetic variation, melanin protects against UV radiation and thus is an important defense system in human skin against harmful factors. Being the largest organ of the body that is always under the influence of internal and external factors, the skin often reacts to those agents by modifying the constitutive pigmentation pattern. The focus of this review is to provide an updated overview of important physiological and biological factors that increase pigmentation and the mechanisms by which they do so. We consider endocrine factors that induce temporary (e.g., during pregnancy) or permanent (e.g., during aging) changes in skin color, environmental factors (e.g., UV), certain drugs, and chemical compounds, etc. Understanding the mechanisms by which different factors and compounds induce melanogenesis is of great interest pharmaceutically (as therapy for pigmentary diseases) and cosmeceutically (e.g., to design tanning products with potential to reduce skin cancer risk).
Numerical Investigation of a Supersonic Cavity Flameholder (2014)

Simulation results are presented for non-reacting flow within a supersonic cavity flameholder. The freestream is air at Mach 2. A case is simulated with no fuel injection, and two cases are simulated with different rates of ethylene fuel injected through holes located on the back face of the cavity. The simulations correspond to a series of experiments for which particle image velocimetry measurements of two velocity components were made within the cavity. The flow within the cavity is computed using unsteady hybrid Reynolds-averaged Navier-Stokes/large-eddy simulation, as well as steady-state Reynolds-averaged NavierStokes simulations. A thorough grid resolution study is presented in which the resolution required to resolve the flow within the cavity is determined. The effects of wall temperature and the thickness of the oncoming turbulent boundary on the solutions is examined and found not to affect the mean velocity and turbulence, and to affect mean mixing only slightly. For steady-state Reynolds-Averaged Navier-Stokes simulations, several turbulence models are used and compared to the hybrid Reynolds-averaged Navier-Stokes/large-eddy simulation results, and the effects of the turbulent Schmidt number, are investigated. The influence of the side walls are investigated by comparing simulations of the full-width duct to simulations of a partial-width duct that uses periodic boundary conditions. The results of the simulations are also compared to the velocity measurements from the experiments, and the hybrid Reynolds-averaged Navier-Stokes/large-eddy simulation results are found to compare well with the experiment in most locations.
Protective effect of creatinol O-phosphate (COP) on some experimental arrhythmias in vitro and in vivo. (1979)

The activity of N-methyl-N-(beta-hydroxyethyl)guanidine O-phosphate (creatinol O-phosphate, COP) on two in vitro and in vivo experimental arrhythmias was investigated. The substance proved to be active in delaying the onset time of aconitine induced arrhythmias in guinea-pig atria. COP showed also a definite antagonizing activity against chloroform-induced ventricular fibrillation in mice.
PROSPECTIVE EVALUATION OF SURGEONS' USE OF ULTRASOUND IN THE EVALUATION OF TRAUMA PATIENTS (1993)

Ultrasound diagnostic imaging has been demonstrated to be a valuable investigative tool in the evaluation of trauma patients in Europe and Japan. In the United States, however, ultrasound has not been widely used by trauma surgeons because of its lack of availability in the trauma resuscitation area and the associated cost and lack of full-time availability of a technician. In this prospective study, four attending trauma surgeons, four trauma fellows (PGY 6 and 7), and 25 surgical residents (PGY 4) at a level I trauma center were trained in specific ultrasound techniques to identify fluid in trauma patients with thoracoabdominal injuries. Their ultrasound evaluations of 476 patients demonstrated that in 90 patients with clinically significant injuries, ultrasound imaging successfully detected injury in 71, for a 79% sensitivity. Specificity was 95.6%. We conclude that (1) surgeons can rapidly and accurately perform and interpret ultrasound examinations; and (2) ultrasound is a rapid, sensitive, specific diagnostic modality for detecting intraabdominal fluid and pericardial effusion.
Abstract 3330: HER2 overexpression induces membrane deformation that increases cell motility (2014)

Abstract Approximately 20% of breast cancers (BC) are characterized by the gene amplification and overexpression of HER2, a member of the ErbB/HER receptor family. While targeted therapies against HER2 effectively delay disease progression in this BC subtype, details of how overexpressed HER2s drive these tumors to malignancy are still unclear. To better understand this process, we investigated various cellular responses to HER2 overexpression in individual live cells. We developed novel single receptor diffusion analyses that determine the activation status of HER2 by diffusivity, to estimate average HER2 activity per single cell. Surprisingly, we found HER2 overexpression induces membrane deformation, which depends only on the HER2 density, but not the receptor activation status. Moreover, this membrane deformation lowers the available surface area for formation of focal adhesion sites, resulting in reduced cell adhesion and increased cell motility. These findings suggest there are signaling-independent roles of HER2 overexpression in disease progression of HER2 positive BCs. Citation Format: Inhee Chung, Mike Reichelt, Donald Dowbenko, Ira Mellman, Mark Sliwkowski. HER2 overexpression induces membrane deformation that increases cell motility. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3330. doi:10.1158/1538-7445.AM2014-3330
Pathways and Kinetics of Anisole Pyrolysis Studied by NMR and Selective 13C Labeling. Heterolytic Carbon Monoxide Generation (2011)

Abstract By applying 13C and 1H NMR spectroscopy the pyrolysis of site-selectively 13C-enriched (H313CO12C6H5) and normal anisole compounds was studied in the dark at 0.001–1.0 M (M, mol dm−3) and at 400–600 °C (supercritical conditions). Conversion of the 13C-labeled methyl group was confined to the methoxy-originated fragments, 13CO and 13CH4, and the reactive intermediate, H13CHO*. The normal phenyl group, 12C6H5– was converted to benzene, 12C6H6 and phenol, 12C6H5OH without ring disintegration. The pyrolysis consists of two elementary steps: (1) the rate-determining unimolecular ether-bond fission (k1) to generate the fragmented product C6H6 and energized intermediate H13CHO* through the intramolecular proton transfer from the methoxy group to the phenyl, and (2) the fast bimolecular disproportionation (k2) through the intermolecular proton/hydride transfer from H13CHO* to H313COC6H5 to produce 13CO, 13CH4, and C6H5OH. CO is generation by the heterolytic (ionic) mechanism in contrast to the homolytic (radical) one via the phenoxy radical intermediate (C6H5O•) in the literature despite the agreement of the rate constant (k1) and the activation energy.
Wear, Debris, and Biologic Activity of Cross-linked Polyethylene in the Knee (2004)

Cross-linked polyethylene currently is being introduced in knee prostheses. The wear rates, wear debris, and biologic reactivity of non cross-linked, moderately cross-linked, and highly cross-linked polyethylene have been compared in multidirectional wear tests and knee simulators. Multidirectional pin-on-plate wear studies of noncross-linked, moderately cross-linked (5 Mrad), and highly cross-linked (10 Mrad) polyethylene showed a 75% reduction in wear with the highly cross-linked material under kinematics found in the hip, but only a 33% reduction under wear in kinematics representative of the knee. In knee simulator studies, with the fixed-bearing press-fit, condylar Sigma cruciate-retaining knee under high kinematic input conditions, the wear of 5 Mrad moderately cross-linked polyethylene was 13 +/- 4 mm per 1 million cycles, which was lower (p < 0.05) than the wear of clinically used, gamma vacuum foil GUR 1020 polyethylene (23 +/- 6 mm/1 million cycles). For the low-contact stress mobile-bearing knee, the wear of moderately cross-linked polyethylene was 2 +/- 1 mm per 1 million cycles, which was lower (p < 0.05) than GVF GUR 1020 polyethylene (5 +/- 2 mm/1 million cycles). The wear debris isolated from the fixed-bearing knees showed the moderately cross-linked material had a larger percentage volume of particles smaller than 1 mum in size, compared with GVF GUR 1020 polyethylene. Direct cell culture studies of wear debris generated in sterile wear simulators using multidirectional motion showed a increase (p < 0.05) in tumor necrosis factor-alpha levels and reactivity for GUR 1050 cross-linked polyethylene debris compared with an equivalent volume of noncross-linked GUR 1050 polyethylene. The use of cross-linked polyethylene in the knee reduces the volumetric wear rate. However, the clinical significance of reduced fracture toughness, elevated wear in abrasive conditions, and the elevated tumor necrosis factor-alpha release from smaller more reactive particles warrant further investigation.
The Drosophila Ral GTPase Regulates Developmental Cell Shape Changes through the Jun NH2-terminal Kinase Pathway (1999)

The Ral GTPase is activated by RalGDS, which is one of the effector proteins for Ras. Previous studies have suggested that Ral might function to regulate the cytoskeleton; however, its in vivo function is unknown. We have identified a Drosophila homologue of Ral that is widely expressed during embryogenesis and imaginal disc development. Two mutant Drosophila Ral (DRal) proteins, DRal(G20V) and DRal(S25N), were generated and analyzed for nucleotide binding and GTPase activity. The biochemical analyses demonstrated that DRal(G20V) and DRal(S25N) act as constitutively active and dominant negative mutants, respectively. Overexpression of the wild-type DRal did not cause any visible phenotype, whereas DRal(G20V) and DRal(S25N) mutants caused defects in the development of various tissues including the cuticular surface, which is covered by parallel arrays of polarized structures such as hairs and sensory bristles. The dominant negative DRal protein caused defects in the development of hairs and bristles. These phenotypes were genetically suppressed by loss of function mutations of hemipterous and basket, encoding Drosophila Jun NH(2)-terminal kinase kinase (JNKK) and Jun NH(2)-terminal kinase (JNK), respectively. Expression of the constitutively active DRal protein caused defects in the process of dorsal closure during embryogenesis and inhibited the phosphorylation of JNK in cultured S2 cells. These results indicate that DRal regulates developmental cell shape changes through the JNK pathway.
Ultrastructure of surface components of Streptococcus gallolyticus (S. bovis) strains of differing virulence isolated from pigeons (1999)

Virulence of Streptococcus gallolyticus (S. bovis) strains isolated from pigeons is associated with the presence of the extracellular proteins A, T1, T2 and T3. Based on the presence or absence of these proteins, six supernatant-phenotypes are distinguished. Experimental infection studies have indicated that strains belonging to the A-T1, A+T1, A+T2 and A+T3 groups are highly virulent for pigeons, strains belonging to the A-T3 groups are moderately virulent and A-T2 strains are of low virulence. In this study the surface structure of 15 pigeon S. gallolyticus strains representing high, moderate and low virulence supernatant-phenotypes was examined by electron microscopy. The presence of capsular material was determined by transmission electron microscopy after polycationic ferritin labelling and immunostabilization. Capsules from cells labelled with polycationic ferritin were usually thicker than those from cells exposed to antiserum. The capsule of the virulent strains had a regular, continuous appearance whilst irregularity of the capsule was a characteristic of the low virulence A-T2 strains. Negative staining revealed the presence of fimbriae in all strains belonging to the high virulence A-T1, A+T1, A+T2 and A+T3 supernatant groups and in one strain of the moderately virulent A-T3 group. The fimbriae were thin, flexible structures with a diameter of approximately 3-4 nm and a length of up to 700 nm. Fimbriae as described above were absent in two other A-T3 strains examined and in the low virulence A-T2 strains. Results from this study indicate that morphological differences in surface structure exist among virulent and low virulence pigeon S. gallolyticus strains, and that the capsule and/or fimbriae are possibly involved in virulence.
Driving decision-making analysis of lane-changing for autonomous vehicle under complex urban environment (2017)

Lane-changing decision-making is critical to complete driving mission for autonomous vehicles under complex urban environment. The complex information (such as the running conditions of interfering vehicles, signal lamp, and road facilities) have a great influence on autonomous vehicle's lane-changing decision. This paper proposes to use the Rough Set theory to abstract the lane-changing rules to support the decision-making of autonomous vehicles under the complex urban environment. Firstly, a virtual urban traffic environment is built by Prescan (a simulation environment for developing advanced driver assistant system). Secondly, the Rough Set theory is proposed to reduce the influence of weak interdependency data, and extract the driver's decision rules. Finally, the result is that: 1) During the intention generation process of lane-changing, the decision-making a is associated only with the relative distance between the subject Car and the interfering Car2 (D <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) and the relative velocity between the subject Car and the leading Car1 (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> ). 2) Both of the decision-making rules during intention generation and implementation phase process are extracted based on Rough Set method, which provide a theoretical basis for the lane-changing decision-making under complex urban environment.
Threshold tracking techniques in the study of human peripheral nerve (1998)

Conventional electrophysiological tests of nerve function focus on the number of conducting fibers and their conduction velocity. These tests are sensitive to the integrity of the myelin sheath, but provide little information about the axonal membrane. Threshold tracking techniques, in contrast, test nerve excitability, which depends on the membrane properties of the axons at the site of stimulation. These methods are sensitive to membrane potential, and to changes in membrane potential caused by activation of ion channels and electrogenic ion pumps, including those under the myelin sheath. This review describes the range of threshold tracking techniques that have been developed for the study of human nerves in vivo: resting threshold is compared with the threshold altered by a change in environment (e.g., ischemia), by a preceding single impulse (e.g., refractoriness, superexcitability) or impulse train, or by a subthreshold current (e.g., threshold electrotonus). Few clinical studies have been reported so far, mainly in diabetic neuropathy and motor neuron disease. Threshold measurements seem well suited for studies of metabolic and toxic neuropathies but insensitive to demyelination. Until suitable equipment becomes more widely available, their full potential is unlikely to be realized.
Automatic visualization of the mandibular canal in relation to an impacted mandibular third molar on panoramic radiographs using deep learning segmentation and transfer learning techniques (2022)

Sufficiently qualified models could delineate the mandibular canal in relation to an impacted third molar on panoramic radiographs using a segmentation technique. Transfer learning appears to be an effective method for creating such models using a relatively small number of data sets.
Opinion influence and evolution in social networks: a Markovian agents model (2017)

In this paper, the effect on collective opinions of filtering algorithms managed by social network platforms is modeled and investigated. A stochastic multi-agent model for opinion dynamics is proposed, that accounts for a centralized tuning of the strength of interaction between individuals. The evolution of each individual opinion is described by a Markov chain, whose transition rates are affected by the opinions of the neighbors through influence parameters. The properties of this model are studied in a general setting as well as in interesting special cases. A general result is that the overall model of the social network behaves like a high-dimensional Markov chain, which is viable to Monte Carlo simulation. Under the assumption of identical agents and unbiased influence, it is shown that the influence intensity affects the variance, but not the expectation, of the number of individuals sharing a certain opinion. Moreover, a detailed analysis is carried out for the so-called Peer Assembly, which describes the evolution of binary opinions in a completely connected graph of identical agents. It is shown that the Peer Assembly can be lumped into a birth-death chain that can be given a complete analytical characterization. Both analytical results and simulation experiments are used to highlight the emergence of particular collective behaviours, e.g. consensus and herding, depending on the centralized tuning of the influence parameters.
Design of a joint research data platform: A use case for severity assessment (2019)

Severity assessment in animal models is a data-driven process. We therefore present a use case for building a repository for interlaboratory collaboration with the potential of uploading specific content, making group announcements and internal prepublication discussions. We clearly show that it is possible to offer such a structure with minimal effort and a basic understanding of web-based services, also taking into account the human factor in individual data collection. The FOR2591 Online Repository serves as a blueprint for other groups, so that one day not only will data sharing among consortium members be improved but the transition from the private to the persistent domain will also be easier.
Constant Power Signaling in Rayleigh Fading Channels: Joint Output Probability Distribution and Information Rate Bounds (2009)

In this paper, we consider a wireless communication scenario in which the channel output is marginally Gaussian, but not jointly Gaussian. In particular, we study the joint probability distribution of channel outputs in correlated Rayleigh fading channels in response to constant power signaling, such as M-ary phase shift keying (MPSK). We show that the distribution of the channel output at any given sampling time is marginally Gaussian. However, the joint distribution of a sequence of channel outputs cannot be jointly Gaussian. A consequence of this result is that the information rates stated to be exact in two recent contributions, are strict upper bounds to the achievable data rates. We examine the tightness of these upper bounds by comparing them with the MPSK upper bound under perfect channel state information (CSI) assumption. We find that the CSI upper bound is considerably tighter in slow fading channels, high signal-to-noise ratios, and low-dimension (such as binary) PSK signaling.
Isolation of secondary plant compounds from Aphanamixis polystachya as feeding deterrents against adult Tribolium castaneum (Coleoptera: Tenebrionidae). (2000)

Sub-fractions of an acetone extract of Aphanamixis polystachya (Meliaceae) seeds were evaluated for their feeding deterrent effects on adult Tribolium castaneum (Coleoptera: Tenebrionidae). The results show that a sub-fraction A-142 was highly feeding deterrent to T. castaneum. This fraction was isolated and analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). Four compounds were identified. 2-methoxy-2-hydroxy propanoic acid might be the active compound against T castaneum.
THE MIRACLE OF EVERYDAY HEALING (1985)

Paul Brand, MD, is Chief of the Rehabilitation Branch of the United States Public Health Service Hospital in Carville, Louisiana, as well as a Clinical Professor of Surgery at Louisiana State University Medical School. He has attained world stature as a hand surgeon. Philip Yancey is Editor-at-Large for Christianity Today and Campus Life magazines. He is coauthor with Paul Brand of Fearfully and Wonderfully Made and In His Image.