gebhart/patrepeval huggingface dataset:
Improvement of odor assessment in a life cycle assessment framework. (2014)

Artisan Pizza is the art of creating the perfect pizza. We provide all the tips, recipes, and product reviews to yield the most amazing pizza at home. No need for a wood brick oven pizza with these guides, recipes and ways to use your standard grill to obtain the perfiect fluffy and crispy crust.
Transducer-actuator systems and methods for performing on-machine measurements and automatic part alignment (2023)

Systems and methods for performing on-machine measurements and automatic part alignment, including: a measurement component operable for determining the position of a part on a machine; and an actuation component operable for adjusting the position of the part by contacting the part with a predetermined force responsive to the determined position of the part. The measurement component consists of a transducer. The actuation component consists of a linear actuator. Optionally, the measurement component and the actuation component consist of a single linear actuator operable for contacting the part with a first lighter force for determining the position of the part and with a second harder force for adjusting the position of the part. The actuation component is utilized in a substantially horizontal configuration and the effects of gravitational drop of the part are accounted for in the force applied and the timing of the contact.
Forensic DNA and bioinformatics (2006)

The field of forensic science is increasingly based on biomolecular data and many European countries are establishing forensic databases to store DNA profiles of crime scenes of known offenders and apply DNA testing. The field is boosted by statistical and technological advances such as DNA microarray sequencing, TFT biosensors, machine learning algorithms, in particular Bayesian networks, which provide an effective way of evidence organization and inference. The aim of this article is to discuss the state of art potentialities of bioinformatics in forensic DNA science. We also discuss how bioinformatics will address issues related to privacy rights such as those raised from large scale integration of crime, public health and population genetic susceptibility-to-diseases databases.
Infection after fracture osteosynthesis – Part I (2017)

Bone and surgical site infections after osteosynthesis are notoriously difficult to manage and pose a tremendous burden in fracture management. In this article, we use the term osteosynthesis-associated infection (OAI) to refer to this clinical entity. While relatively few surgically treated fractures become infected, it is challenging to perform a rapid diagnosis. Optimal management strategies are complex and highly customized to each scenario and take into consideration the status of fracture union, the presence of hardware and the degree of mechanical stability. At present, a high level of relevant evidence is unavailable; most findings presented in the literature are based on laboratory work and non-randomized clinical studies. We present this overview of OAI in two parts: an examination of recent literature concerning OAI pathogenesis, diagnosis and classification and a review of treatment options.
Graph signal processing for traffic analysis and forcasting (2020)

The application of Graph Signal Processing (GSP) techniques to traffi c &#13;\nnetworks in urban settings is a challenging problem that has become the topic&#13;\nof many studies in recent works. In this paper, we analyze the effectiveness&#13;\nof these techniques to sparse image data collected in suburban environments&#13;\nusing the STREETS dataset. We start with spectral analysis on these traffi c&#13;\nstates with the goal of discovering patterns in traffi c data not obvious to the&#13;\ncasual observer. Second, we introduce structure into the traffic forecasting&#13;\nproblem with an adaptive graph filter. The performance of this filter is compared to non-graphical methods. Finally, we attempt to classify anomalous&#13;\ntra ffic incidents via graph wavelet decompositions.
Pathogenic Rickettsia species evade autophagosomal maturation and reduce anti-microbicidal pro-inflammatory IL-1 responses to support their intracellular survival (2022)

Abstract Species of genus Rickettsia are obligate intracellular bacterial parasites of a wide range of arthropod and vertebrate hosts. Some Rickettsia species are responsible for several serious human diseases. One fascinating feature of these stealthy group of pathogens is their ability to exploit host cytosolic defense responses to their benefits. However, the precise mechanism by which pathogenic Rickettsia elude host immune defense responses remains to be determined. Here, we observed that pathogenic R. typhi and R. rickettsii , but not non-pathogenic R. montanensis become ubiquitinated and induce autophagy upon entry into bone-marrow-derived macrophages. Moreover, unlike R. montanensis, R. typhi , and R. rickettsii colocalized with LC3B but not with Lamp2 upon host cell entry. Finally, we observed that pathogenic but not non-pathogenic Rickettsia reduce pro-inflammatory IL-1 responses. In sum, we identified a previously unappreciated pathway by which pathogenic, but not non-pathogenic, Rickettsia become ubiquitinated and induced autophagy, but avoided autophagolysosomal destruction as well as inflammasome-mediated anti-microbicidal IL-1 cytokine responses to establish an intracytosolic niche in macrophages.
RAMO: management network for telecommunications environment equipment (2005)

The RAMO network is the fundamental tool for operating the technical environment equipment of telecommunications centres which concern the power supply, cooling system, building surveillance, access control, security, EMC and electrostatic environment. It implements functions which make it possible to analyse the quality of the equipment's performance in operation, to precisely identify equipment failures to reduce their mean time to repair. The type of equipment included in this network varies depending on the size of the centre which houses it. It comprises the power supply systems, consisting of an electrical generator, an AC distribution cabinet, a conversion and power storage cabinet from the Alfatel range, catering for all power requirements from 2.5 kVA to 60 kVA, and from the Geode range for power greater than 100 kVA, together with the cooling systems and uninterruptible power supplies. The networking of all these items of equipment on an X.25 protocol using France Telecom's operating architecture comprises the RAMO network.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Switching Between Intravenous and Oral Pantoprazole (2001)

Proton pump inhibitors (PPIs) are the most effective antisecretory drugs available for controlling gastric acid acidity and volume. They are the drugs of choice in the treatment of moderate-to-severe gastroesophageal reflux disease, hypersecretory disorders, and peptic ulcers. Currently in the United States, they are only available in an oral formulation. However, pantoprazole will soon be available in an intravenous formulation and will extend the power of PPIs to inpatient hospital settings. Intravenous pantoprazole has been shown to be effective and safe in clinical trials. Intravenous pantoprazole is indicated for the treatment of patients who require PPI therapy but who are unable to take oral medication. Intravenous pantoprazole has been shown to maintain acid suppression in patients switched from oral PPIs, so no change in dosage is required when switching from one formulation to the other. Potential hospital-based uses for intravenous PPI therapy include perioperative use as prophylaxis for acid aspiration syndrome during induction of anesthesia, prophylaxis for stress-related mucosal disease, and management of gastrointestinal bleeding from stress or acid peptic disease.
Prevent DNS Cache Poisoning Using Security Proxy (2011)

DNS has been suffering from cache poisoning attack for a long time. The attacker sends camouflaged DNS response to trick the domain name server, and inserts malicious resource record into the cached database. Because the original DNS protocol only depends on 16-bit transaction ID to verify the response packet, it is prone to be guessed by the attacker. Although many strategies such as transaction randomizing, source port randomizing and the 0×20 technique have been applied to improve the resistance of DNS, the attacker still has chance to poison DNS server in an acceptable time. Other more complicated strategy such as DNSSEC which provides stricter prevention mechanism is not easy to deploy and is not widely adopted yet. To address the problem, we present a novel strategy called Security Proxy. The architecture can be easily implemented and deployed on existing DNS server without modification of DNS server itself. The embedded two schemes Selective Re-Query and Security Label Communication can cooperate and effectively prevent the cache poisoning attack. We analyze our strategy from both the capability and efficiency. Then we find that our Security Proxy has obvious advantage over the original transaction ID, the source port randomizing and 0×20 techniques.
Curing reaction of bisphenol-A based benzoxazine with cyanate ester resin and the properties of the cured thermosetting resin (2011)

Curing reaction of bisphenol-A based benzoxazine with cyanate ester resin and the properties of the cured thermosetting resin were investigated. The cure behavior of benzoxazine with cyanate ester resin was monitored by model reaction using nuclear magnetic resonance (NMR). As a result of the model reaction, the ring opening reaction of benzoxazine ring and thermal self-cyclotrimerization of cyanate ester group occurred, and then the phenolic hydoroxyl group generated by the ring opening reaction of benzoxazine ring co-reacted with cyanate ester group. The properties of the cured thermosetting resin were estimated by mechanical properties, electrical resistivity, water resistance and heat resistance. The cured thermosetting resin from benzoxazine and cyanate ester resin showed good heat resistance, high electrical resistivity and high water resistance, compared with the cured thermosetting resin from benzoxazine and epoxy resin.
Study of the subjective performance of a range of MPEG-2 encoders (1995)

The paper presents the results of subjective tests organized in November 1994 by the HAMLET subgroup WP2. These tests, carried out in accordance with Rec. ITU-R 500-5, compare the performances of different types of MPEG-2 encoders: 1. The software encoder of the MPEG-2 technical documentation (reference), 2. An exact simulation of the hardware encoder that is being built in the same RACE project, 3. An optimized software encoder and 4. An SNR scalable encoder. The results reveal that the MPEG-2 standard leaves much room for optimization in the encoder. They also illustrate that optimizations carried out for the HAMLET hardware encoder lead to important improvements. Finally, they show that almost comparable quality of the MPEG-2 reference software encoder at 7 Mbit/s and the SNR scalable encoder at 3+4 Mbit/s for the base + enhancement layer. >
Review of: "A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation" (2022)

A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation" explored the roles of Polycystin-1 (PC-1, PKD1) in endothelial cells (EC) in using EC-specific Pkd1 knockout (Pkd1 ecKO) mice. The authors showed that PC-1 regulated arterial contractility and demonstrated that this event occurred through the formation of an interdependent signaling complex with PC-2 in ECs.
Abstract 12995: Sex and Race Differences in Ventricular-Arterial Coupling in the Coronary Artery Risk Development in Young Adults (CARDIA) Study (2020)

Background: Coupling between the left ventricle and arterial system can be quantified as the ventricular-arterial coupling (VAC) ratio with 1.00 reflecting optimal physiology. VAC has been most studied in heart failure, with higher values associating with worse prognosis, but its correlates among individuals without heart failure are less characterized. Thus, in the Coronary Artery Risk Development in Young Adults (CARDIA) study we tested the hypothesis that VAC ratio differs by sex and race. Methods: We studied VAC in 2,812 (42% male, 47% black, median age 50 years) CARDIA year 25 exam participants with transthoracic echocardiogram data available and no history of heart failure, myocardial infarction, peripheral vascular disease, or valvular disease. VAC was calculated as arterial elastance (Ea) divided by LV end systolic elastance (Ees). Ea and Ees were calculated as end systolic pressure/stroke volume and by the modified Chen single beat method, respectively. Associations between sex and race with VAC were tested in multivariable-adjusted linear regression. Results: VAC ratio differed by both sex and race with higher unadjusted values in men (median 1.14 [25 th -75 th percentile 1.08-1.20]) compared with women (1.11 [1.05-1.17]), p &lt; 0.001, and white (1.12 [1.07-1.18]) compared with black (1.11 [1.06-1.18]) individuals, p = 0.004. In adjusted models, male sex (beta 0.027 [95% CI 0.021 to 0.037], p &lt;0.001) and white race (0.007 [0.002 to 0.012], p = 0.009) remained associated with higher VAC ratio (Figure 1). Sex, LV ejection fraction (beta -0.096 [95% CI -0.099 to -0.093], and total arterial compliance (-0.045 [-0.049 to -0.041]) were the most strongly associated correlates of VAC. Systolic blood pressure, creatinine, heart rate, LDL, and triglycerides inversely associated with VAC. Age and LV remodeling index positively associated with VAC. Conclusions: In community dwelling middle-aged adults, male sex and white race independently associated with higher VAC.
Development of an EOG-Based Automatic Sleep-Monitoring Eye Mask (2015)

Health care researchers have recently developed several home-based sleep monitoring systems and mobile applications that support healthy sleep by monitoring a user's sleep environment, activities, or sleep quality. This study describes the design and evaluation of an electrooculogram (EOG)-based system for an automatic sleep monitoring. Compared with polysomnogram or electroencephalogram recordings, EOG has the advantage of easy placement and can be operated by the users themselves. We also design an intelligent eye mask that is user friendly for measuring sleep stage and quality. Two user experiments were carried out to demonstrate that the proposed system produces valid measurements of sleep stage and sleep quality and has good usability and reliability while not disturbing sleep significantly. These findings suggest that our system can also be applied to long-term sleep monitoring or sleep environment control to improve the user's sleep quality and make sleep more comfortable.
Development of Tunable Infrared Parametric Oscillators and Coherent Tunable Source Spectroscopy. (1973)

The authors have completed studies of Na2 by optical pumping and have demonstrated laser action on both the A and B molecular bands. They have initiated work on optically pumping Hg2. They have carried out initial discharge studies of Na2 and have demonstrated a discharge pumped XeF laser.
Degradability of chitosan micro/nanoparticles for pulmonary drug delivery (2019)

Chitosan, a natural carbohydrate polymer, has long been investigated for drug delivery and medical applications due to its biodegradability, biocompatibility and low toxicity. The micro/nanoparticulate forms of chitosan are reported to enhance the efficiency of drug delivery with better physicochemical properties including improved solubility and bioavailability. This polymer is known to be biodegradable and biocompatible; however, crosslinked chitosan particles may not be biodegradable. Crosslinkers (e.g., tripolyphosphate and glutaraldehyde) are needed for efficient micro/nanoparticle formation, but it is not clear whether the resultant particles are biodegradable or able to release the encapsulated drug fully. To date, no studies have conclusively demonstrated the complete biodegradation or elimination of chitosan nanoparticles <i>in vivo</i>. Herein we review the synthesis and degradation mechanisms of chitosan micro/nanoparticles frequently used in drug delivery especially in pulmonary drug delivery to understand whether these nanoparticles are biodegradable.
Transcriptomic profile of cell cycle progression genes in human ovarian granulosa cells. (2019)

The ovarian granulosa cells (GCs) that form the structure of follicle undergo substantial modification during the various stages of human folliculogenesis. These modifications include morphological changes, accompanied by differential expression of genes, encoding proteins which are mainly involved in cell growth, proliferation and differentiation. Recent data bring a new insight into the aspects of GCs' stem-like specificity and plasticity, enabling their prolonged proliferation and differentiation into other cell types. This manuscript focuses attention on emerging alterations during GC cell cycle - a series of biochemical and biophysical changes within the cell. Human GCs were collected from follicles of women set to undergo intracytoplasmic sperm injection procedure, as a part of remnant follicular fluid. The cells were primarily cultured for 30 days. Throughout this time, we observed the prominent change in cell morphology from epithelial-like to fibroblast-like, suggesting differentiation to other cell types. Additionally, at days 1, 7, 15 and 30, the RNA was isolated for molecular assays. Using Affymetrix® Human Genome U219 Array, we found 2579 human transcripts that were differentially expressed in GCs. From these genes, we extracted 582 Gene Ontology Biological Process (GO BP) Terms and 45 KEGG pathways, among which we investigated transcripts belonging to four GO BPs associated with cell proliferation: "cell cycle phase transition", "G1/S phase transition", G2/M phase transition" and "cell cycle checkpoint". Microarray results were validated by RT-qPCR. Increased expression of all the genes studied indicated that increase in GC proliferation during long-term in vitro culture is orchestrated by the up-regulation of genes related to cell cycle control. Furthermore, observed changes in cell morphology may be regulated by a presented set of genes, leading to the induction of pathways specific for stemness plasticity and transdifferentiation in vitro.
Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum (2007)

Although further assessment is needed, these data have suggested that IV administration of meloxicam may be a useful alternative to flunixin meglumine for postoperative treatment of horses with colic.
NIMG-29. DEVELOPING AUTOMATIC SEGMENTATION METHOD FOR BRAIN TUMOR MR IMAGES THAT CAN BE USED AT MULTIPLE FACILITIES (2020)

Abstract BACKGROUND Manual segmentation of brain tumor images from a large volume of MR images generated in clinical routines is difficult and time-consuming. Hence, it is imperative to develop a machine learning model for automated segmentation of brain tumor images. PURPOSE Machine learning models for automated MR image segmentation of gliomas may be useful. However, the image differences among facilities cause performance degradation and impede successful automatic segmentation. In this study, we proposed a method to solve this issue. METHODS We used the data from the Multimodal Brain Tumor Image Segmentation Benchmark (BraTS) and the Japanese cohort (JC) datasets collected from 10 facilities. Three models for tumor segmentation were developed. The BraTS model was trained on the BraTS dataset, and the JC model was trained on the JC dataset; whereas, the Fine-tuning model was a fine-tuned BraTS model using the JC dataset. RESULTS MR images of 544 patients were obtained for the JC dataset. Half of the JC dataset was used for independent testing. The Dice coefficient score of the JC model for the JC dataset was 0.779± 0.137, whereas that of the BraTS model was remarkably lower (0.717 ± 0.207). The mean of the Fine-tuning models for the JC dataset was 0.769 ± 0.138. There was a significant difference between the BraTS and JC models (P &amp;lt; 0.0001) and the BraTS and Fine-tuning models (P = 0.002); however, no significant difference was observed between the JC and Fine-tuning models (P = 0.673). CONCLUSIONS Application of the BraTS model to heterogeneous datasets can significantly reduce its performance; however, fine-tuning can solve this issue. Since our fine-tuning method only requires less than 20 cases, this methodology is particularly useful for a facility where there are a few glioma cases.
Preparation of Rat Sciatic Nerve for <em>Ex Vivo</em> Neurophysiology (2022)

Ex vivo preparations enable the study of many neurophysiological processes in isolation from the rest of the body while preserving local tissue structure. This work describes the preparation of rat sciatic nerves for ex vivo neurophysiology, including buffer preparation, animal procedures, equipment setup and neurophysiological recording. This work provides an overview of the different types of experiments possible with this method. The outlined method aims to provide 6 h of stimulation and recording on extracted peripheral nerve tissue in tightly controlled conditions for optimal consistency in results. Results obtained using this method are A-fibre compound action potentials (CAP) with peak-to-peak amplitudes in the millivolt range over the entire duration of the experiment. CAP amplitudes and shapes are consistent and reliable, making them useful to test and compare new electrodes to existing models, or the effects of interventions on the tissue, such as the use of chemicals, surgical alterations, or neuromodulatory stimulation techniques. Both conventional commercially available cuff electrodes with platinum-iridium contacts and custom-made conductive elastomer electrodes were tested and gave similar results in terms of nerve stimulus strength-duration response.
Biosensors in the Processing and Analysis of Biopharmaceuticals (2012)

This chapter contains sections titled: Introduction Principles and Commercial Applications of Biosensors Use of Biosensors in Biopharmaceutical Production and Processing Conclusions References