gebhart/patrepeval huggingface dataset:
CD3G is within 200 kb of the leukemic t(4;II) translocation breakpoint (1991)

The t(4;11)(q21;q23) has been associated with acute lymphocytic leukemia (ALL) especially in infants. The t(4;11) breakpoint on chromosome 11 is cytogenetically indistinguishable from breakpoints for other leukemia-associated translocations affecting 11q23. The molecular basis of the t(4;11) is unknown although a number of genes have been mapped to 11q23. The CD3D, G, and E genes have been positioned proximal to the 11q23 breakpoint of the 4;11 translocation while the THY1 and ETS1 genes have been mapped distal to this breakpoint. We report evidence that CD3G is within 200 kb of the 4;11 breakpoint as observed by pulsed field gel analysis. A rearrangement of the CD3G gene has been observed in a cell line derived from a patient with the t(4;11) translocation and in a hybrid cell line containing the derivative 11q chromosome derived from this cell line, using the restriction enzymes SacII and ClaI. Similar rearrangements using SacII were observed in 2 further patients with ALL and the t(4;11) translocation. No rearrangements in the same DNA were observed using ETS1, THY1, and D11S29 and a range of rare cutter restriction enzymes. CD3G thus provides a tool for the cloning and analysis of the 4;11 translocation, and poses a question of its possible involvement at long range with this translocation.
Figure S7 from Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival (2023)

&lt;p&gt;DNA methylation analysis in primary TCGA LUADs and comparative analysis of methylation of all CpG sites in the primary and metastatic tumors.&lt;/p&gt;
Remote Data Service Installation on a Grid-enabled Java Platform (2006)

We define a framework for remote service installation, called SIMG (service installation metaservice on grids). Its main goal is to allow grid users to define and safely install their own data filters on remote data servers. Once installed, these filters may be used like the predefined services and may be available for a broader community of users. SIMG is implemented in SUMA/G, a Globus-enabled platform for remote execution of Java bytecode. We also present our experiences using SIMG for defining and remotely installing two complementary services in a content-based image retrieval system.
Corrosion Resistance of Titanium Surgical Implant Alloys: A Review (1979)

The performance of titanium and its alloys in surgical implant applications is examined with respect to the materials' biocompatibility and ability to withstand the corrosive fluids of the human body. Both in-vitro and in-vivo experimentation is reviewed, as well as the reported clinical results. For comparative purposes, other commonly used implant alloys are discussed. Since the corrosion resistance of titanium and its alloys is due to a passive film which covers the metal, a portion of the paper is devoted to the nature of the passive film. Studies dealing with formation, compositions, and structures of titanium passive films, as well as environmental effects on these films are examined. In-vitro studies have been carried out in numerous physiological solutions using various electrochemical techniques. Among the parameters studied were pH, pO2, surface finish, surface treatments, crevice corrosion, galvanic coupling, stress, fatigue, and fretting corrosion. In every study titanium and its alloys compared favorably with the other materials tested. In-vivo studies as early as 1940 showed that titanium is as well tolerated biologically as is stainless steel and Vitallium. More recent animal studies confirmed the early conclusions, and, in fact, it appears that titanium and some of its alloys may be actually better tolerated than stainless steel and the cobalt-chromium alloys. Clinical findings have been consistent with the results of in-vitro and in-vivo studies; not a single corrosion-related failure of a titanium or titanium-alloy implant could be found in the clinical literature. In summary, the available information indicates that titanium and some of its alloys may be the most biocompatible and corrosion-resistant metallic implant materials in present use.
CHAPTER VII (2011)

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Young Age as a Prognostic Factor for Operable Breast Cancer: Significance of Molecular Subtype in Recurrence-Free Survival. (2009)

Abstract Background: Breast cancer is uncommon in young women. Biology of the disease in this age group is poorly understood and the prognostic significance of young age at diagnosis remains controversial. We investigated the clinicopathological characteristics and outcomes of younger breast cancer patients (≤35 years of age), and assessed the prognostic significance of young age according to molecular subtype.Methods: We analyzed 2,474 primary invasive breast cancer patients who underwent surgery between 2000 and 2005. The younger age group consisted of patients aged ≤35 years. Subtypes were defined by expression of hormone receptor (HR) and HER2: luminal (HR+ irrespective of HER2 status), triple-negative (HR- and HER2-) and HER2 (HR- and HER2+).Results: A total of 229 (9.3%) patients were aged ≤35 years. Breast cancers in this age group were associated with larger size, higher lymph node positivity, higher nuclear and histological grades, and elevated Ki-67 index, compared with tumors in older patients. Younger patients had a greater probability of recurrence than older patients (P&amp;lt;0.001). By multivariate analysis, young age remained a significant predictor of recurrence (hazard ratio, 1.54; 95% confidence interval, 1.15-2.06; P=0.004). When the cancer subtypes were considered, young age was a significant predictor of recurrence in patients with both luminal and HER2 subtypes. In patients with the triple-negative subtype, however, young age was not a predictor of recurrence.Conclusions: Young age (≤35 years) was an independent predictor of recurrence for operable breast cancer patients with the luminal and HER2 subtypes, but not for those with the triple-negative subtype. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 4063.
Low-loss, low-cost spontaneous Brillouin-based system for simultaneous distributed strain and temperature sensing (2000)

Summary form only given. The ability to perform long-range distributed sensing fibre strain and temperature measurements with a high spatial resolution has many applications including power utilities, oil industries and structural monitoring. We present results using a novel signal detection technique for resolving independent strain and temperature measurements by obtaining both the spontaneous Brillouin backscattered intensity and frequency shift at every point along the sensing fiber.
Mechanism of maturation and nature of carbohydrate chains of boar sperm acrosin (1991)

The acrosin zymogen proacrosin exists in two molecular forms which are believed to be single-chain polypeptides. During autoactivation in a cell-free system, the 55 and 53 kDa zymogens are sequentially converted into the 49, 36, 31 and 25 kDa forms. A similar mechanism of maturation was revealed, when the calcium ionophore A23187 was added to suspensions of boar spermatozoa. The 49 kDa form has been identified as the first active acrosin form in the maturation cascade. However, this form is indistinguishable from the 53 kDa zymogen in SDS-PAGE at nonreducing conditions. Two carbohydrate chains were evidenced on the acrosin molecule. The chain attached to the Asn3 of the acrosin light chain was enzymatically cleaved without loss of acrosin activity. By contrast, the carbohydrate chain linked to the acrosin heavy chain could be cleaved only after acrosin denaturation. Based on the susceptibility of acrosin to endoglycosidases F and H, a biantennary structure of both carbohydrate chains is proposed.
Consistent activation of the β-catenin pathway by Salmonella type-three secretion effector protein AvrA in chronically infected intestine (2012)

Salmonella infection is a common public health problem that can become chronic and increase the risk of cancer. Live, mutated Salmonella is used to target cancer cells. However, few studies have addressed chronic Salmonella infection in vivo. AvrA is a Salmonella type-three secretion effector that is multifunctional, inhibiting intestinal inflammation and enhancing proliferation. β-catenin is a key player in intestinal renewal, inflammation, and tumorigenesis. We hypothesize that in Salmonella-infected intestine, AvrA chronically activates the β-catenin pathway and increases cell proliferation, thus deregulating the intestinal responses to bacterial infection. We followed mice with Salmonella infection for 27 wk and investigated the physiological effects and role of AvrA on β-catenin in chronically infected intestine. We found that AvrA persistently regulated β-catenin posttranslational modifications, including phosphorylation and acetylation. Moreover, the upstream regulator Akt, transcription factors, T cell factors, nuclear β-catenin, and β-catenin target genes were enhanced in mice infected with Salmonella-expressing AvrA. AvrA has a chronic functional role in promoting intestinal renewal. In summary, we have uncovered an essential role of Salmonella AvrA in chronically activating β-catenin and impacting intestinal renewal in small intestine and colon. Our study emphasizes the importance of AvrA in chronic bacterial infection.
La situació actual en la formació d'educadors en el lleure (2012)

Lapublicacion en el Diari Oficial de la Generalitat de Catalunya y en el Butlleti Oficial de l'Estat de los modulos formativos correspondientes a los cursos de monitor y director de educacion en el ocio infantil y juvenil implican un cambio de paradigma en la formacion de los educadores en el ocio.
A Novel Approach to the Design of Self-Piloting Drills With External Chip Removal, Part 2: Bottom Clearance Topology and Experimental Results (1995)

In the first part of this paper, geometrical relations were formulated to describe the geometry of a self-piloting drill with external chip removal. A novel approach to the design of the cutting tip was proposed and an experimental comparison between conventional and newly designed drills was made. In deep hole drilling, after the tool and the machine, the most important component is the coolant. It is important that the coolant be distributed uniformly within the machining zone to improve chip removal, lubrication and cooling. Thus, in this paper, the coolant flow in the limited space between the drill flanks and the bottom of the hole being drilled (called “bottom clearance”) is emphasized. Experimental investigations were done by using a specially designed workpiece which enables continuous monitoring of coolant flow and pressure distribution in the machining zone. The investigation shows that the newly designed drill is characterized by a significantly better coolant distribution in the bottom clearance resulting in an increase in tool life and better chip removal conditions.
Model-Based Design and it's Application in Power Window (2014)

Along with the continuous development of embedded systems, embedded products take higher requirements on the scale and performance of system software, and contributing to the complexity of control algorithm. So it would take more time and expense to realize the control algorithm. Therefore, traditional design is out of date and cant cope with the modern development rhythm well. While the Model-Based Design, is an efficient design method to deal with complex embedded control systems. It provides a common development and test platform for the engineers. In this paper, we take the power windows control system as example; establish the algorithm model with the Simulink/Stateflow. Then we introduce these process of the control system design which is based on the Model-Based Design method, according to the result of the final experiment, we prove the efficiency of this method, providing a reference for the design of other complex control systems.
Bridge deck cracking and composite action analyses (2010)

According to the American Society of Civil Engineers Report Card (ASCE, 2005), United States infrastructure received a grade point average of D (i.e., poor rating) in 2005. Moreover, the National Bridge Inventory (Federal Highway Administration, 2004) revealed that of more than 594,470 bridges in the US, about 150,981 (25.4%) are considered structurally deficient or functionally obsolete. Hence, major decisions must be made to allocate the limited funds available for repair, rehabilitation, and replacement. The vast majority of deficient bridges will require at least partial or full concrete deck replacement. Accordingly, many state departments of transportation expend significant effort and resources on the construction of durable reinforced concrete bridge decks. Previous research indicates that the development of transverse cracking in newly constructed concrete bridge decks continues to be a nationwide problem. In this study, three potential causes of cracking are investigated: 1) excessive restraint of the placed concrete, 2) design for deflection, and 3) high-strength gain of the concrete. Various bridge types were considered and modeled using the finite element (FE) computer program, ABAQUS. The FE model included the effect of shear studs, concrete strength, live load on the placement of concrete in existing bridges, and deflection limits. Existing data and results from this research indicate that the shear studs, concrete strength, and rebar locations have very little effect on bridge deck cracking. Depending on concrete pouring sequence, construction scenarios, and truck weight spectra, loading from adjacent truck traffic may lead to bridge deck cracking. To control bridge deck flexibility that causes an increase in concrete tensile stresses, new bridges with high-strength steel in excess of 70 ksi need to be designed with New Jersey Department of Transportation deflection limits.
Opacity Table Generation (2021)

Radiation opacity is a key property of material systems which describes the absorption and scattering of photons. Such processes are an important part of energy transport, diagnostics, and astrophysical phenomena. Recent experiments in iron opacity and continuum lowering have sparked renewed interest in and careful vetting of opacity models. Even within the local thermodynamic equilibrium approximation, opacity varies over a large parameter space: material, temperature, density, and energy. Opacity tables that span wide regimes of this parameter space are of prime importance to radiation-hydrodynamics codes. Accurate opacity calculations cannot be achieved inline during a radiation hydrodynamics simulation since they involve accounting for all possible electron transitions of all important atomic states of a thermal ensemble. Livermore’s current framework utilizes precalculated tables at many densities, temperatures, and energies. Last year, the opacity theory team completed an L2 milestone concerning the development of a new code, Opus, which served the dual purpose of creating a modern code infrastructure and version control as well as the basis for training new members of that team, a critical need as key members near or are passed retirement. For the current L2 milestone, we exercised and validated Opus on three elements: boron, carbon, and nitrogen, which have few enough electrons to allow a careful convergence study over many input parameters. Here, we report on the production of new tables, show their convergence with respect to important parameters, state some of their limitations, and document a mostly automated production process. In this section, we address the milestone completion criteria, found on the title page and the subsection headings. In section 2, we validate Opus against Tycho and compare with TabOp and Atomic. Section 3 details some of the physics implemented in Opus and relevant to this report. We then cover details of the density-temperature grid in section 4 and do a spectral comparison between different parameter settings and different codes in section 5. After summarizing these results in section 6, we give instructions how to run the opacity table scripts in appendix A and document the scripts and input/output files in appendix B.
Effective retrieval with distributed collections (1998)

Article Effective retrieval with distributed collections Share on Authors: Jinxi Xu Center for Intelligent Information Retrieval, Computer Science Department, University of Massachusetts, Amherst, Amherst, MA Center for Intelligent Information Retrieval, Computer Science Department, University of Massachusetts, Amherst, Amherst, MAView Profile , Jamie Callan Center for Intelligent Information Retrieval, Computer Science Department, University of Massachusetts, Amherst, Amherst, MA Center for Intelligent Information Retrieval, Computer Science Department, University of Massachusetts, Amherst, Amherst, MAView Profile Authors Info & Claims SIGIR '98: Proceedings of the 21st annual international ACM SIGIR conference on Research and development in information retrievalAugust 1998 Pages 112–120https://doi.org/10.1145/290941.290974Online:01 August 1998Publication History 100citation616DownloadsMetricsTotal Citations100Total Downloads616Last 12 Months6Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
ChemInform Abstract: Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3‐(Cyclopentyloxy)‐4‐ methoxybenzamides and Analogues. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Objective Estimation of Loudness Discomfort Level using Auditory Brainstem Evoked Responses (1987)

The loudness discomfort level (LDL) is of importance in the fitting of hearing aids, but very young children are unable to provide a subjective judgement of LDL. Therefore the relationship between Jewett wave V latency and subjective loudness was investigated to ascertain if objective estimation of LDL is possible. ABR recordings were taken from 8 normally hearing subjects at the stimulus intensity corresponding to their LDL and at stimulus levels from 10 to 30 dB below this. The wave V latency/intensity function did not correlate well with the LDL. However, the slope of this function did correlate to a high degree and a predictive model of LDL was derived. Identical measurements were then taken from a sample of 12 cochlear-impaired subjects with a range of audiometric profiles. Their subjective LDLs could be predicted from the wave V latency function to an accuracy of +/- 5 dB, using the model derived from the normally-hearing subjects. This model appeared to be equally valid for all the degrees and profiles of hearing loss included in the sample and showed a closer relationship to LDL than did absolute wave V latency or estimates derived from the acoustic reflex.
An empirical study into the robustness of split covariance addition (SCA) for human motion tracking (2004)

Accurate human body tracking is extremely important for many virtual and augmented reality systems. However, tracking human motion is extremely difficult. Some of the difficulties arise from the fact that accurate process models of human motion are difficult to derive. Approximate models can have substantial time-correlated process noise terms. We examine the effectiveness of using the split covariance addition (SCA) algorithm as part of a human head orientation estimation system. We perform a series of empirical experiments to compare the performance of several implementations of SCA with an extended Kalman filter (EKF). The results suggest that the benefits of SCA are mixed. It leads to filters, which are slightly more robust and have slightly more accurate angular velocity estimates than the EKF. However, the absolute orientation estimate is slightly worse than the EKF.
Analysis of MH-1A Loss of Coolant Accident (1972)

Abstract : Analyses of a postulated loss of coolant accident (LOCA) for the MH- 1A Nuclear Power Plant are presented for large and intermediate size breaks in the primary system. Methods and assumptions consistent with AEC Interim Acceptance Criteria were used in evaluating the performance of the Emergency Core Cooling System (ECCS). The computer codes RELAP-3 for reactor system blowdown and THETAl-B for fuel element heatup were used to perform these calculations at a core power of 49.5 MW(t). The results of the core temperature transient for various break conditions are presented and the required cooling capability of a system meeting the AEC interim criteria is discussed.
Air distribution improvement of closed type server cabinets using flow baffles. (2015)

This paper addresses the problems of airflow in the narrow cold and hot passages of a close type server cabinet. The problems of flow distribution and recirculation could lead to hotter air mixed into the cool air supplied to the servers. Flow baffles are evaluated for isolation of cold and hot passages, and minimize the air flowing between the servers. Computer models were set up to study the flow and temperature fields. Supply heat index (SHI) that indicates the enthalpy rise due to warm air infiltration into the cool air was used in the performance evaluation. The simulation results show flow baffles could improve on the flow distribution. Compared with the base case with SHI 0.29, the flow baffles can reduce SHI to 0.03. It was concluded that flow baffles are viable solution to the problems of hot air mixing into cold air in close server cabinets.
Lymphocoeles in renal homograft recipients. (1976)

1) The graft should be anastomosed on side opposite a functioning shunt. 2) Lymphocoeles have an occult presentation and should be actively sought for as they may produce urinary obstruction. 3) Serial ultrasound is an excellent method of diagnosis and follow-up. 4) Unless urinary obstruction is present management should be conservative as spontaneous resolution may occur. 5) Ideal surgical management is problematical. Repeated needle aspirations should be approached with caution. Lymphocoeles are an uncommon but well documented complication of renal transplantation (Schweizer et al, 1972; Koehler et al, 1972; Christiansen et al, 1974; Rashid et al, 1974). They represent definite hazards and can either directly or indirectly contribute to morbidity or even mortality in the post-transplant patient. They must be differentiated from other pelvic masses such as urinomas, haematomas and perinephric abscesses as they all require different modes of treatment. As a rule, the diagnosis of one from another is straightforward, but as certain clinical features are shared, differentiation can on occasions be more difficult. In order to clarify some of these problems and outline a mode of therapy, a study was carried out in patients who have presented with lymphocoeles in our unit.