gebhart/patrepeval huggingface dataset:
Genetic Polymorphisms in CYP3A4 are Associated with Withdrawal Symptoms and Adverse Reactions in Methadone Maintenance Patients (2011)

These results suggested that genetic variants in the CYP3A4 gene may be useful indicators for the severity of side effects and withdrawal symptoms for methadone treatment.
Spectroscopic and Structural Study of Some Oligosilanylalkyne Complexes of Cobalt, Molybdenum and Nickel (2019)

Metal induced stabilization of α-carbocations is well known for cobalt- and molybdenum complexed propargyl cations. The same principle also allows access to reactivity enhancement of metal coordinated halo- and hydrosilylalkynes. In a previous study, we have shown that coordination of oligosilanylalkynes to the dicobalthexacarbonyl fragment induces striking reactivity to the oligosilanyl part. The current paper extends this set of oligosilanylalkyne complexes to a number of new dicobalthexacarbonyl complexes but also to 1,2-bis(cyclopentadienyl)tetracarbonyldimolybdenum and (dippe)Ni complexes. NMR-Spectroscopic and crystallographic analysis of the obtained complexes clearly show that the dimetallic cobalt and molybdenum complexes cause rehybridization of the alkyne carbon atoms to sp³, while in the nickel complexes one π-bond of the alkyne is retained. For the dicobalt and dimolybdenum complexes, strongly deshielded <sup>29</sup>Si NMR resonances of the attached silicon atoms indicate enhanced reactivity, whereas the <sup>29</sup>Si NMR shifts of the respective nickel complexes are similar to that of respective vinylsilanes.
Right anterior minithoracotomy for aortic valve replacement. (2015)

We present the case of a 78-year-old lady with severe aortic stenosis who underwent cardiovascular investigations for ingravescent dyspnea [New York Heart Association (NYHA) functional class III] undergoing minimally invasive aortic valve replacement (MIAVR) through right anterior minithoracotomy (RT). The patient’s height and weight were 170 cm and 62 kg, respectively. Risk factors included hypertension, diabetes, hypercholesterolemia and chronic obstructive pulmonary disease. Transthoracic echocardiography showed a mean aortic transvalvular gradient of 52 mmHg and peak gradient of 88 mmHg. Left ventricular ejection fraction was 45% and systolic pulmonary artery pressure was 50 mmHg.
The What-If Tool: Interactive Probing of Machine Learning Models (2019)

A key challenge in developing and deploying Machine Learning (ML) systems is understanding their performance across a wide range of inputs. To address this challenge, we created the What-If Tool, an open-source application that allows practitioners to probe, visualize, and analyze ML systems, with minimal coding. The What-If Tool lets practitioners test performance in hypothetical situations, analyze the importance of different data features, and visualize model behavior across multiple models and subsets of input data. It also lets practitioners measure systems according to multiple ML fairness metrics. We describe the design of the tool, and report on real-life usage at different organizations.
Globally bounded tracking controllers for rigid robot systems (1997)

In this note we consider tracking control of rigid robot systems under input constraints. Using the combination of two controllers we are able to obtain globally asymptotically stable closed-loop error-dynamics while keeping the applied actuator torques within in advance specified bounds. This idea is also exploited successfully in case only position measurements are available, or when parameter uncertainties call for an adaptive control scheme.
On the Use of Absorbing Metasurfaces in Microwave Imaging (2020)

&lt;p&gt;Microwave imaging (MWI) systems are usually enclosed within casings, e.g., in order to contain the utilized coupling liquid or to help mount the antenna system. On the other hand, inverse scattering algorithms, which are used to process the measured microwave scattering data, often assume that the background medium of the imaging system extends to infinity (i.e., unbounded background medium assumption). Thus, they do not consider the reflections occurring at the system enclosure. For such algorithms to yield successful images, these reflections need to be minimized, e.g., via the use of a lossy coupling liquid. As an alternative to a lossy background medium which also reduces the desired signal level, this paper investigates the use of metallic-backed absorbing metasurfaces as the MWI system enclosure in order to (i) reduce these reflections, and also (ii) to shield the MWI system from external interference. Using simulated data, we then show that standard inverse scattering algorithms, employing the free-space assumption, can successfully process the data collected under the metasurface enclosure and yield acceptable permittivity images. The advantages and disadvantages of absorbing metasurface enclosure, along with the limitations of this study, will also be discussed. Finally, an absorbing metasurface is fabricated and its reflectivity is experimentally evaluated.&lt;/p&gt;
Unintended impacts of a national antipsychotic reduction initiative among nursing facility residents with and without Alzheimer's disease (2023)

Our study documents antipsychotic use significantly declined in non-ADRD clinical and exempt cohorts, where such reductions may not be clinically warranted. Furthermore, ARI-associated compensatory increases in PMs do not offset these reductions. Changes in PM utilization and diagnostic make-up of residents using PMs require further investigation to assess the potential for adverse clinical and economic outcomes.
Microbubble Trapping by Nonlinear Bubble Oscillation Using Pumping Wave (2007)

Microbubble manipulation by acoustic radiation force may play an important role in future drug delivery systems, because the required bubble manipulations, such as bubble trapping at the desired position and payload release by bubble destruction using a high-intensity ultrasonic wave, are controlled by ultrasonic waves. In this paper, a novel method of microbubble trapping by bubble nonlinear oscillation is proposed. Two ultrasonic waves, which have a harmonic frequency relation, are used in order to generate the force for trapping bubbles. The first wave is a pumping wave, which has a relatively high sound pressure. This wave is used for inducing the nonlinear oscillation of bubbles. The second wave is a control wave, whose frequency is set to be the harmonic frequency of the nonlinear bubble oscillation. The pressure gradient of the control wave in conjunction with the harmonic component of nonlinear oscillation generates the Bjerknes force applied to bubbles. This force forms multiple traps with a narrow separation for bubbles, which flow into the cross area of the two ultrasonic waves.
Nonhazardous solvent composition and method for cleaning metal surfaces (2023)

A solvent composition for displacing greasy and oily contaminants as well as water and/or aqueous residue from metallic surfaces, especially surfaces of radioactive materials so that such surfaces can be wiped clean of the displaced contaminants, water and/or aqueous residue. The solvent composition consists essentially of a blend of nonpolar aliphatic hydrocarbon solvent having a minimum flash point of about 140.degree. F. and 2 to 25 volume percent of a polar solvent having a flash point sufficiently high so as to provide the solvent composition with a minimum flash point of at least 140.degree. F. The solvent composition is nonhazardous so that when it is used to clean the surfaces of radioactive materials the waste in the form of paper or cloth wipes, lab coats and the like used in the cleaning operation is not considered to be mixed waste composed of a hazardous solvent and a radioactive material.
Development of a Micro-Pitot Traverse for Pressure Measurements in the Boeing-AFOSR Mach 6 Quiet Tunnel (2023)

View Video Presentation: https://doi.org/10.2514/6.2023-2260.vid Accurate boundary-layer profile measurements are critical for studying hypersonic laminarturbulent transition. To further research capabilities in the Boeing-AFOSR Mach 6 Quiet Tunnel (BAM6QT) a micro-pitot traverse system is developed capable of taking off-surface pressure fluctuation measurements. The system is capable of moving three micro-pitot probes around an axisymmetric cone placing the sensors at specified axial, azimuthal and wall-normal positions within the boundary layer of the model. The motivation for the development of this system was spurred by previous experiments investigating cross-flow in the BAM6QT which noted a need for off-surface pressure measurements to advance investigations. The micro-pitot system developed here will be used for future cross-flow experiments to accomplish such. This paper will specifically cover the design, construction and implementation of the micro-pitot traverse system. This will be accomplished in two parts. First, an overview of the traverse system and a discussion about actuation is presented. Then, the construction of the micro-pitot probes is discussed. Pitot mounted sensors encounter high frequency attenuation. As such a custom built analog compensator is designed to counteract the attenuation caused by the pitot tube. The compensated micro-pitot probes and traverse system are then combined in the BAM6QT to validate that it worked as expected in the BAM6QT.
Abstract PD6-09: Herpet study- PET imaging of HER2 expression in breast cancer using the novel Affibody tracer [18F]GE-226, a first in patient study (2021)

Abstract Background 20% of breast cancers have over-expression of the human epidermal growth factor receptor-2 (HER2), which is an adverse prognostic factor and used to guide therapy selection. At present HER2 expression can only be determined using biopsy material which is then analysed using immunohistochemistry or fluorescence in situ hybridisation. GE-226 is a radiolabelled Affibody® tracer which binds to the HER2 receptor with high affinity at a different epitope than trastuzumab. Heterogeneous expression does exist but the impact this has on treatment response has not been well assessed. A non-invasive method for determining HER2 expression could have several advantages and help select appropriate therapy for patients. Trial DesignPatients with locally advanced or metastatic breast cancer were recruited and scanned for 65 mins after iv injection of 200MBq (mean activity injected for each patient 198 MBq (range 164-219MBq), mean radiochemical purity 94.6%) of tracer, with one dynamic bed position, and then a half-body scan was performed. Blood sampling was used to measure metabolism of the tracer. Safety was recorded. HER2-extracellular domain (ECD) domain was measured in blood. The original accrual target was 16 patients. Tumoural uptake was quantified by semi-quantitative and fully quantitative parameters in HER2 positive and HER2 negative tumours. ResultsThirteen patients were recruited. Scans were well tolerated. There were no serious adverse events. GE-226 was metabolised into a single metabolite in the liver. 96.8 % parent remained at 60 minutes post injection. There was a significant difference between HER2 positive and HER2 negative tumoural uptake of tracer as measured by SUVmean and SUVmax (p&amp;lt;0.05). Comparing HER2 positive to HER2 negative cases, there was also a significant difference between tumour to normal tissue uptake ratios (p&amp;lt;0.05). Heterogeneous uptake was observed in the same patient. Tumoural uptake increased over time. Uptake in salivary glands and the thyroid gland was noted. In one patient GE-226 was able to differentiate between lymphadenopathy due to sarcoidosis and cancer and was superior to FDG which had shown widespread uptake in the same patient. Conclusions[18F]GE-226 imaging is well tolerated and shows promise for imaging of HER2 positive breast cancer. Further studies with this agent are now planned. Citation Format: Laura M. Kenny, Gosala S. Gopalakrishnan, Tara D. Barwick, Vijay Vaja, S. Hope McDevitt, Robert Punjani, Neva H. Patel, Rathi Ramakrishnan, Naina R. Patel, Stephen Johnston, Janine Mansi, Gary J. Cook, Fiona J. Gilbert, Franklin I. Aigbirhio, Duncan Hiscock, Eric O. Aboagye. Herpet study- PET imaging of HER2 expression in breast cancer using the novel Affibody tracer [18F]GE-226, a first in patient study [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PD6-09.
A UHF Proximity Micro-Transceiver for Mars Exploration (2006)

A UHF half-duplex micro-transceiver for future Mars exploration missions is described. The transceiver target specifications include a volume of less than 1 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , mass of less than 10 grams, and power consumption of <40 mW on receive and 50 mW, 300 mW, or 3 W on transmit. It is compatible with a subset of Prox-1 protocols and supports transmission rates from 1 to 4096 ksps, depending on RF link parameters, in BPSK or QPSK format. Command and control instructions can be received at 1 or 8 ksps. In addition to its low mass/power features, temperature compensation to -100 C and radiation tolerance to 100 krad allow operation outside of large, thermally controlled, shielded enclosures, further reducing the mass and complexity of exploration vehicles. Although designed around Mars missions and environmental constraints, the transceiver is expected to be useful as well in other proximity links where a small/low-power radio compatible with Prox-1 protocols is desired
Effect of Polycarboxylate Superplasticizer on Properties of Phosphogypsum-Based Cement (2012)

By using XRD、SEM and other experimental methods, some details of polycarboxylate superplasticizer on the hydration products and performance of phosphogypsum-based cement(PBC) can be obtained. It can be found that the polycarboxylate superplasticizer makes the structure of the cement stone more compact, and significantly increases the strength of the cement. Besides, it can also improve the anti-carbonation and degradation properties of that cement.
Towards Fairness of Cryptocurrency Payments (2016)

Motivated by the great success and adoption of Bitcoin, a number of cryptocurrencies such as Litecoin, Dogecoin, and Ethereum are becoming increasingly popular. Although existing blockchain-based cryptocurrency schemes can ensure reasonable security for transactions, they do not consider any notion of fairness. Fair exchange allows two players to exchange digital "items", such as digital signatures, over insecure networks fairly, so that either each player gets the other's item, or neither player does. Given that blockchain participants typically do not trust each other, enabling fairness in existing cryptocurrencies is an essential but insufficiently explored problem. In this paper, we explore the solution space for enabling the fair exchange of a cryptocurrency payment for a receipt. We identify the timeliness of an exchange as an important property especially when one of the parties involved in the exchange is resource-constrained. We introduce the notion of strong timeliness for a fair exchange protocol and propose two fair payment-for-receipt protocol instantiations that leverage functionality of the blockchain to achieve strong timeliness. We implement both and compare their security and efficiency.
The Unusual Thermal Stabilization of MOCVD Precursors by the Dibenzoyl Methanate Group: Liquid Injection MOCVD of Tantalum Oxide and Niobium Oxide Using M(OEt)4(dbm) Precursors (2002)

Thin films of tantalum oxide and niobium oxide have been deposited by liquid injection MOCVD using solutions of Ta(OEt)4(dbm) (1) or Nb(OEt)4(dbm) (2) (dbm = dibenzoyl methanate = 1,3-diphenyl-1,3-propanedionate). The presence of the dbm ligand imparts unusual thermal stability to the complexes, allowing oxide films to be deposited at relatively high substrate temperatures (650 °C and higher). Single-crystal X-ray diffraction (XRD) shows the complexes to be mononuclear, with distorted octahedral configurations.
Cationic DABCO-based Catalyst for Site-Selective C−H Alkylation via Photoinduced Hydrogen-Atom Transfer (2021)

A novel class of hydrogen-atom transfer (HAT) catalysts based on the readily available and tunable 1,4-diazabicyclo[2.2.2]octane (DABCO) structure was designed, and their photoinduced HAT catalysis ability was demonstrated. The combination of the optimal HAT catalyst with an acridinium-based organophotoredox catalyst enables highly efficient and site-selective C−H alkylation of substrates ranging from unactivated hydrocarbons to complex molecules. Notably, a HAT catalyst with additional substituents adjacent to a nitrogen atom further improved the site-selectivity. Mechanistic studies suggested that the N-substituent of the catalyst plays a crucial role, assisting in the generation of a dicationic aminium radical as an active species for the HAT process.
The convolution neural network based agent vehicle detection using forward-looking sonar image (2016)

We propose the convolution neural network (CNN) based underwater object recognition and detection solution using forward-looking sonar image for localization of agent vehicle (small ROV). We designed the multiple underwater vehicle system with the autonomous underwater vehicle (AUV) equipped with the forward-looking sonar and the agent vehicle linked to the AUV through a tether cable. For localization of agent vehicle, we use the forward-looking sonar images. The CNN based object recognition algorithm trained the agent vehicle's sonar image and detected it in the overall sonar images. We found that the CNN algorithm successfully recognized the agent vehicle in the sonar image. The goal of our research is to propose a solution to apply the CNN based recognition algorithm to the underwater robotics. Finally, it shows the elevated recognition rate in the underwater and we can get the agent vehicle's localization data.
SURG-02. LASER INTERSTITIAL THERMAL THERAPY FOR BRAIN METASTASES: OUTCOMES AND PREDICTORS OF LOCAL RECURRENCE (2019)

Abstract BACKGROUND: LITT has been used to treat recurrent brain metastasis after stereotactic radiosurgery (SRS). Little is known about how best to assess the efficacy of treatment, specifically the ability of LITT to control local tumor progression post-SRS. Objectives: Evaluate the predictive factors associated with local recurrence after LITT. METHODS: Retrospective study with consecutive patients with brain metastases treated with LITT. Based on radiological aspects, lesions were divided into progressive disease after SRS (recurrence or radiation necrosis) and new lesions. Primary endpoint was time to local recurrence. RESULTS: 61 consecutive patients with 82 lesions (5 newly diagnosed, 46 recurrence and 31 radiation necrosis). Freedom from local recurrence at 6 months was 69.6%, 59.4% at 12, and 54.7% at 18 and 24 months. Incompletely ablated lesions had a shorter median time for local recurrence (p&amp;lt; 0.001). Larger lesions (&amp;gt;6cc) had shorter time for local recurrence (p=0.03). Dural based lesions showed a shorter time to local recurrence (p=0.01). Tumor recurrence/newly diagnosed had shorter time to local recurrence when compared to RN lesions (p=0.01). Patients receiving systemic therapy after LITT had longer time to local recurrence (p=0.01). In multivariate Cox-regression model the HR for incomplete ablated lesions was 4.88 (p&amp;lt; 0.001), 3.12 (p=0.03) for recurrent tumors, and 2.56 (p=0.02) for patients not receiving systemic therapy after LITT. Complication rate was 26.2%. CONCLUSIONS: Incompletely ablated and recurrent tumoral lesions were associated with higher risk of treatment failure and were the major predicting factors for local recurrence. Systemic therapy after LITT was a protective factor regarding local recurrence.
XBAR physics and next generation filter design (2021)

XBARs are laterally-excited bulk acoustic resonators consisting of interdigital transducers (IDT) on thin piezoelectric plates. Their low loss and excellent piezo-coupling are ideal for wideband 5G cellular and next-generation Wi-Fi filters. We present measurements of 5 GHz and 6 GHz Wi-Fi filters fabricated by Resonant with respective bandwidths exceeding 600 MHz or 1200 MHz respectively. Avoiding spurs over such large bandwidths while maintaining high power performance requires careful choice of the electrode thickness. FEM simulations demonstrate a minimum in spurious content at particular values of the metal thickness. This minimum can be understood by calculating propagating mode dispersion curves in two 2D structures: 1) an infinite lithium niobate (LN) plate which matches the XBAR structure between electrodes, and 2) an infinite composite plate with LN and thick metal which matches the XBAR structure in the electrode region. We show that the resonant XBAR mode for electrode thickness near the spur minimum can be approximately described as Al between electrodes, and A3 in and beneath the electrodes. The minimum in spur content occurs close to the metal thickness where the A1 mode of the open plate between electrodes is best matched to the A3 mode of the composite LN and thick metal plate at the electrodes.
Supplementary References from Considerations for the Clinical Application of Chimeric Antigen Receptor T Cells: Observations from a <i>Recombinant DNA Advisory Committee Symposium</i> Held June 15, 2010 (2023)

Supplementary References from Considerations for the Clinical Application of Chimeric Antigen Receptor T Cells: Observations from a &lt;i&gt;Recombinant DNA Advisory Committee Symposium&lt;/i&gt; Held June 15, 2010
Use of Nanosilica in Silicone Rubber Coatings for Ceramic Insulators in Coastal Areas - Field Results (2008)

Field experiments were performed to study the relative performance of nano size silica filler (nanosilica) and micron size silica filler (microsilica) as fillers in silicone rubber as coatings for ceramic or glass insulators in coastal areas. Leakage current was measured and recorded for 45 days of exposure to a coastal environment that is recognized by the utility as critical. After field exposure, the insulators had their surface contamination evaluated. The results indicate that nanosilica filled silicone rubber had lower leakage current values than microsilica filled silicone rubber coated insulators due to less surface contamination.
Spatial deblocking algorithm based on human visual system (2009)

We introduce a new deblocking algorithm that can remove the blockiness without blurring image details. After modeling the blocking artifacts as well as the real edges, the proposed algorithm controls the suppression of the blocking artifact based on the human visual system. Through simulations, we show that our algorithm can successfully reduces the blocking artifacts without excessive blurring.
Decubitus Risk: Is Shear More Important than Pressure? (2000)

A mechanical load through which the capillaries are closed causes tissue ischaemia of the skin. Most authors agree that it is this tissue ischaemia that is the main factor in the cause of pressure sores. Different combinations of mechanical load on the skin may have the same effect within the skin. The aim of this study is to evaluate the effect that different combinations of pressure and shear have on blood flow within the skin. The skin blood flow was measured by means of skin oxygen tension. Different load combinations on the skin surface, for which the maximum shear stress within the skin remained equal, showed no significant difference in skin blood flow. Research should therefore focus on load situations within the skin instead of pressure measurements on the skin surface only.