gebhart/patrepeval huggingface dataset:
Experimental tests and signal processing for a cryogenic L-band phased array feed on the Green Bank Telescope (2014)

A collaboration has been underway for the last several years to develop an L-band multipixel phased array feed for the Green Bank Telescope. These efforts will culminate in the deployment of a new wide-field observing instrument, Focal L-band Array for the GBT (FLAG).We report on progress on the cryogenic front end receiver system and real-time digital signal processing back end.
A monoclonal antibody-purified soluble target cell antigen inhibits nonspecific cytotoxic cell activity. (1990)

We have previously reported the characterization of mAb derived against NC-37 target cells. mAb 18C2 and 1E7 inhibit fish cytotoxicity by binding to target cells and thus preventing the formation of conjugates with fish nonspecific cytotoxic cells (NCC). It was therefore presumed that these inhibitory mAb were specific for the target cell Ag necessary for effector cell recognition. mAb 1D4 and 7C6 bind to NC-37 cells but do not inhibit fish cytotoxic activity. We now report the isolation and purification of the Ag recognized by mAb 18C2 (inhibitor) and 1D4 (noninhibitor) by affinity chromatography of solubilized NC-37 target cell extracts. The 18C2-purified soluble target Ag (STAg) caused inhibition of cytotoxicity when preincubated with fish NCC. This inhibitory activity was reversible and dose-dependent ranging from 20 to 70% inhibition with 25 to 100 micrograms 18C2 purified STAg/10(6) NCC. STAg purified by 1D4 affinity chromatography had no effect on fish cytotoxicity. mAb 18C2 and 1E7 preabsorbed with 18C2 STAg lost their inhibitory activity when tested in the fish NCC cytotoxicity assay. Preabsorption of the same mAb with 1D4 STAg had no effect on their activity.
MSPL/TMPRSS13 (2007)

Two variant cDNAs, mosaic seine protease large-form (MSPL) and transmembrane protease serine 13 (TMPRSS13), have been identified from a human lung cDNA library by polymerase chain reaction. The deduced amino acid sequences of these proteins show a type II transmembrane protein structure with a unique and long cytoplasmic tail containing tandem repeat phosphorylation motifs of protein kinases, a transmembrane domain, and a trypsin-like serine protease domain at the extracellular C-terminal side. These proteins have an identical serine protease sequence except for the C-terminal ends, and the consensus protease domain exhibits 42, 39 and 43% sequence identity with those of plasma kallikrein, hepsin and transmembrane protease serine 2 (TMPRSS2), respectively. Although both genes are widely expressed in various tissues, they are predominantly expressed in human lung, placenta, pancreas and prostate. TMPRSS13 is expressed higher than MSPL in thymus, spleen and peripheral blood lymphocytes, particularly in CD8+ cells and CD19+ cells. Enzymatic properties of the recombinant soluble MSPL and TMPRSS13 show that these enzymes preferentially recognize the sites consisting of paired basic amino acid residues, and are strongly inhibited by aprotinin, benzamidine and Bowman-Birk trypsin inhibitor, but poorly inhibited by alpha 1-antitrypsin and leupeptin. These properties raise the possibility that MSPL and TMPRSS13 play roles in the proteolytic processing of prohormones, precursors of growth factors, and also play roles in the pathogenicity of many viruses and bacteria in vivo.
Creutzfeldt-Jakob disease with slow progression. A mimickry of progressive supranuclear palsy. (2007)

Sporadic Creutzfeldt-Jakob disease (sCJD) does not always present with typical clinical signs, such as myoclonus in association with periodic sharp-wave complexes. We present a 67-year old female patient with initial falls and vertical gaze palsy, suggesting the diagnosis of Progressive Supranuclear Palsy (PSP). EEG and MRI were not contributory. Typical clinical and paraclinical CJD signs were only seen after 17 months. The diagnosis was confirmed by autopsy. - CJD can be a neurodegenerative chameleon. The present case adds to the scare literature of slowly evolving CJD mimicking Parkinsonism related to tauopathies.
Irrigation financing in perspective (2011)

Irrigation provides supplementary water supply to one-fifth of the world's cultivated land, from which one-third of the world's food is harvested. Many of the world's poorest people are dependent on this food. Billions of low-income people struggle to supplement inadequate and unreliable rainfall with irrigation.
Marital Status and Crowding Intensity (The Case of Multifamily Apartments in Lagos, Nigeria) (2013)

In Nigeria, crowded housing is one of the housing stresses that bother policy-makers and housing authorities.This study examines the crowding levels in seven marital status categories among the occupants of Lagos State Development and Property Corporation’s apartments. The focus is on the capacity of an apartment’s internal spaces to meet the sleeping needs of households in different marital arrangements. A case study of four housing estates was purposively selected among Lagos State Development and Property Corporation’s multifamily categories, with a population of 7,764 apartments. A sample of 7.5% (582)was chosen using stratification and systematic random techniques. A pretested questionnaire instrument was used to collect therelevant demographic data of occupants. The occupants in different marital arrangements were grouped into three: households that harboured one to two occupants; households that harboured three to five occupants; and households that harboured six or more occupants. The result shows that households containing three to five persons were the most dominant in all apartment types while households that contain six or more persons were very few. Generally, the result showed no substantial disparity in the incidence of crowding among households of various marital classifications in different apartment types. The link between “Separated” and “Divorced” was revealed, as both types were not found among respondents living in two-bedroom apartments. The number of occupants in the “just single” and “married” categories were high compared to others. These results are significant for policies regarding occupancy, crowding and design of Lagos State Development and Property Corporation’s apartments.
Photoreaction of 4-Substituted Quinoline N-Oxide and 2(1H)-Quinolinone in Propionic Acid (1977)

Abstract 4-Substituted cis-3-ethyl-2-oxo-1,2,3,4-tetrahydro-2-quinoline was formed as a major product, by irradiation of quinoline N-oxide and 2(1H)-quinolinone substituted with an electron-withdrawing group at the C-4 position in propionic acid. Also, the products were confirmed by direct comparison with synthesized compounds.
The total synthesis of a technetium chelate - tamoxifen complex (1999)

A potential agent for imaging breast cancer has been synthesized by derivatization of the anti-estrogen tamoxifen. A multistep synthesis was required to conjugate a technetium chelate to tamoxifen in such a fashion that the biodistribution of the complex should mimic that of the parent compound.Key words: tamoxifen, radioimaging, technetium, synthesis.
Dual-Band Resistance Compression Networks for Improved Rectifier Performance (2014)

In this work, the concept of dual-band resistance compression networks is introduced and applied to the design of rectifier circuits with improved performance. The use of resistance compression networks (RCNs) minimizes the sensitivity of rectifier circuits to variations in the surrounding environment, such as input power level and changes in the rectifier load. The proposed dual-band RCN can be used as the matching network located between the antenna and the rectifying element of a dual-band rectifier for energy harvesting applications. A dual-band ( 915 MHz /2.45 GHz) rectifier based on RCN is designed and characterized showing improved performance in comparison with a conventional dual-band envelope detector by exhibiting improved RF-dc conversion efficiency and reduced sensitivity versus output load and input power variations.
Lipid-polymer hybrid nanoparticles: Development & statistical optimization of norfloxacin for topical drug delivery system (2017)

Poly lactic acid is a biodegradable, biocompatible, and non-toxic polymer, widely used in many pharmaceutical preparations such as controlled release formulations, parenteral preparations, surgical treatment applications, and tissue engineering. In this study, we prepared lipid-polymer hybrid nanoparticles for topical and site targeting delivery of Norfloxacin by emulsification solvent evaporation method (ESE). The design of experiment (DOE) was done by using software to optimize the result, and then a surface plot was generated to compare with the practical results. The surface morphology, particle size, zeta potential and composition of the lipid-polymer hybrid nanoparticles were characterized by SEM, TEM, AFM, and FTIR. The thermal behavior of the lipid-polymer hybrid nanoparticles was characterized by DSC and TGA. The prepared lipid-polymer hybrid nanoparticles of Norfloxacin exhibited an average particle size from 178.6 ± 3.7 nm to 220.8 ± 2.3 nm, and showed very narrow distribution with polydispersity index ranging from 0.206 ± 0.36 to 0.383 ± 0.66. The surface charge on the lipid-polymer hybrid nanoparticles were confirmed by zeta potential, showed the value from +23.4 ± 1.5 mV to +41.5 ± 3.4 mV. An Antimicrobial study was done against <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>, and the lipid-polymer hybrid nanoparticles showed potential activity against these two. Lipid-polymer hybrid nanoparticles of Norfloxacin showed the %cumulative drug release of 89.72% in 24 h. A stability study of the optimized formulation showed the suitable condition for the storage of lipid-polymer hybrid nanoparticles was at 4 ± 2 °C/60 ± 5% RH. These results illustrated high potential of lipid-polymer hybrid nanoparticles Norfloxacin for usage as a topical antibiotic drug carriers.
Grain Refinement during Melt-spinning of Dilute Cu-base and N i-base Alloys. (1997)

In order to obtain a fine and equiaxed grain structure in a casting, grain formation has been examined in past work in terms of undercooling of the melt, promotion of heterogeneous nucleation and remelting or fragmentation of dendrites. Some techniques to obtain grain refinement are commercially used, but the mechanism is not fully understood. The addition of a second element to a pure metal is one of the possible ways to obtain grain refinement in bulk samples. In the present work, this approach was taken with a melt-spinning method, which allows for an extremely directional and rapid heat extraction. Dilute Cu-base and Ni-base alloys with selected solute additions were studied to examine the operating mechanism of the grain refinement in melt-spun alloys. In melt-spun Cu-base and Ni-base binary alloys, it was found that the type of solidification structure (columnar or equiaxed) can be predicted by the constitutional undercooling parameter, P, in most alloy systems as well as the case of bulk samples. There were some cases in which the melt-spun grain structure was not consistent with the P parameter prediction. In all cases, however, the final solidification temperatures of the alloys appear to be correlated to the development of grain refinement. As a result, to explain all the results in the present work, a model has been proposed which considers the effects of the parameter P, dendrite fragmentation and final solidification temperature concurrently and offers useful guidance in alloy design for optimum grain refinement.
BASIC BIOMECHANICS AND WORKPLACE DESIGN (2021)

Occupational biomechanics is an interdisciplinary field in which information from both the biological sciences and engineering mechanics is used to quantify the forces present on the body during work. Biomechanics assumes that the body behaves according to the laws of Newtonian mechanics. The approach to a biomechanical assessment is to characterize the human–work system situation through a mathematical representation or model. This chapter focuses on the information required to develop proper biomechanical reasoning when assessing the physical demands of a workplace. It presents a series of key biomechanical concepts that constitute the underpinning of biomechanical reasoning. The National Research Council reviewed the scientific literature in epidemiology, biomechanics, tissue mechanobiology, and workplace intervention strategies and concluded that there is a significant relationship between workplace design and the occurrence of musculoskeletal disorders of the low back and upper extremities. Shoulder pain is believed to be one of the most underrecognized occupationally related musculoskeletal disorders.
Peak reduction in OFDM using second-order cone programming relaxation (2014)

In this paper, we address the problem of peak-to-average power ratio (PAPR) reduction in orthogonal frequency-division multiplexing (OFDM) systems. We formulate the problem as an error vector magnitude (EVM) optimization task with constraints on PAPR and free carrier power overhead (FCPO). This problem, which is known to be NP hard, is shown to be approximated by a second-order cone programming (SOCP) problem using a sequential convex programming approach, making it much easier to handle. This approach can be extended to the more general problem when PAPR, EVM, and FCPO are constrained simultaneously. Our performance results show the effectiveness of the proposed approach, which allows good performance with lower computational complexity and infeasibility rate than state-of-the-art PAPR-reduction convex approaches. Moreover, in the case when all the three system parameters are constrained simultaneously, the proposed approach outperforms the convex approaches in terms of infeasibility rate, PAPR, and bit error rate (BER) performances.
Designing fiber dispersion for broadband parametric amplifiers (2006)

We present a method to determine the fiber chromatic dispersion curve that optimizes the gain bandwidth and ripple of fiber optical parametric amplifiers. We found that controlling high order dispersion terms a great enhancement of the gain spectrum is achieved. We provide a simulation example of a photonic crystal fiber, designed to control up to the sixth order dispersion parameter that gives 33 dB of gain from 1440 nm to 1600 nm, within 0.2 dB of gain variation.
Doping challenges in exploratory devices for high performance logic (2002)

This paper presents an outlook for doping processes in high performance logic as new device structures and materials are introduced with the hope of continuing CMOS device performance improvements into the 10-20 nm channel length regime. Materials and structures that are considered interesting in this scaling work are strained silicon and strained silicon grown on silicon germanium, ultra thin silicon on insulator (SOI) materials, high-k dielectrics and metal gates, and double gated MOSFETs. Ramifications of using these materials on implant and doping technologies will be discussed.
Chemische Transportreaktionen. IX. Der Transport von TiN mit HCl im Molybdänröhrchen (1962)

Abstract Die Umsetzung von TiN mit HCl, bei der H 2 , N 2 und die gasförmigen Chloride TiCl 4 , TiCl 3 und TiCl 2 nebeneinander entstehen, verläuft oberhalb 1300°C hinreichend schnell und reversibel, so daß sie den chemischen Transport von TiN im Temperaturgefälle ermöglicht. Im Zusammenhang hiermit wurde eine Arbeitstechnik für hohe Temperaturen entwickelt, bei der ein aus Molybdänfolie zusammengerolltes, elektrisch beheiztes Röhrchen als Reaktionsraum dient. Der Transporteffekt entspricht bei hinreichend hoher Temperatur dér Erwartung, wenn man als Modell die Diffusion zwischen Räumen zugrunde legt, in denen Gleichgewicht zwischen TiN und der Gasphase herrscht. Unterhalb 1200°C bleibt der Transport aus kinetischen Gründen – wegen der Stabilität der N 2 ‐Molekel – unmeßbar klein.
Pelvic inflammatory disease isolates of Neisseria gonorrhoeae are distinguished by C1q-dependent virulence for newborn rats and by the sac-4 region (1997)

The virulence mechanism of Neisseria gonorrhoeae in pelvic inflammatory disease (PID) is not well understood, and an objective diagnostic method to identify patients with PID is lacking. We investigated the hypothesis that development of PID was associated with a C1q-dependent virulence property of gonococcal strains. Recent development of a C1q-dependent experimental model of gonococcal infection (S. Nowicki, M. Martens, and B. Nowicki, Infect. Immun. 63:4790-4794, 1995) created an opportunity to evaluate this hypothesis in vivo. Therefore, the virulence of 32 clinical isolates (18 PID isolates and 14 local infection [LI] isolates) was evaluated in experimental rat pups. A serum bactericidal assay was used to characterize a gonococcal serum-resistant (ser(r)) phenotype. PCR primers designed to amplify a suitable-size gonococcal sac-4 DNA fragment (unique for serum-resistant donor JC1) were used to evaluate the association of serum-resistant genotype sac-4 with two phenotypes: C1q-dependent virulence expressed in vivo and resistance to bactericidal activity of human serum expressed in vitro. Strains were also characterized by auxotyping and serotyping. Of 32 gonococcal strains, 15 (46.7%) caused C1q-dependent bacteremia in rat pups and were sac-4 positive and ser(r). However, of the 15 isolates, 13 (87%) represented strains associated with human PID and 2 (13%) were associated with LI. None of the strains that were completely serum-sensitive (ser(s)) and sac-4 negative produced C1q-dependent bacteremia in rat pups, suggesting that both ser(r) and sac-4 were required for infection. The serum-resistant recombinant recipient of sac-4 produced C1q-dependent bacteremia in the rat model similarly to the serum-resistant donor of sac-4; the serum-sensitive parent strain did not produce bacteremia. These data suggest that sac-4-mediated serum resistance conferred C1q-dependent virulence and is a unique characteristic associated with PID. These newly identified features may contribute to the understanding of the pathogenic mechanism of PID-associated strains and open perspectives for establishing novel diagnostic methods.
Current-voltage characteristics and ON/OFF ratio in ferroelectric tunnel junctions (2012)

Current-voltage characteristics of poled ferroelectric tunnel junction have been theoretically studied with the consideration of piezoelectric effect and interface potential due to the depolarization effect. Compared with piezoelectric effect, barrier potential changed by polarization switching is more significant. Tunnel currents with low and high resistances during the reading process are distinct, which have potential applications as low-cost, high-density, and fast-speed ferroelectric memories. The obtained ON/OFF ratio in a symmetry SrRuO3/BaTiO3/SrRuO3 structure is around 50 under a small applied voltage.
Visualization of dynamic behavior of liquid water in the microporous layer of polymer electrolyte fuel cell during water injection by time-resolved X-ray computed tomography (2021)

Liquid water behavior in the microporous layer (MPL) of a polymer electrolyte fuel cell (PEFC) was investigated using time-resolved X-ray computed micro-tomography (CT) to elucidate the unsteady flow during flooding. The water was injected into an MPL laminated on top of the substrate of a gas diffusion layer (GDL) to simulate the cathode in an operating PEFC. A CT scan time as high as 4.2 s was achieved, which enabled capture of the water motion in MPL pores with sizes of ca. 30 and 100 μm. Dynamic water transport from a hydrophobic MPL pore to the hydrophilic carbonaceous binder that bonds the substrate fibers was observed.
Prophylactic Administration of Liposomal Amphotericin B Is Superior to Treatment in a Murine Model of Invasive Aspergillosis after Hematopoietic Cell Transplantation (2002)

With use of a novel model of invasive Aspergillus fumigatus, the efficacy of prophylactic versus therapeutic administration of liposomal amphotericin B (L-AmB) was tested in C57BL/6 mice. After lethal irradiation and transplantation of whole bone marrow (d 0), animals were challenged with conidia either intravenously or via nasal instillation on d +3 and divided into 3 groups: group I received 5% dextrose in water throughout the study period; group II received L-AmB, 5 mg/kg, beginning on d +4; and group III received L-AmB, 5 mg/kg on d -4, d -2, d 0, and d +2, then daily starting d +4. Groups I and II did not survive intravenous challenge, whereas group III had a 40% survival rate. After nasal instillation of conidia, the survival was 25%, 35%, and 85% for mice in groups I, II, and III, respectively. These results demonstrate that prophylactic administration of L-AmB increased early survival against lethal challenge with A. fumigatus, compared with therapy instituted after infection.
An improved method for generating subtracted cDNA libraries using phage lambda vectors (1995)

Journal Article An improved method for generating subtracted cDNA libraries using phage lambda vectors Get access Holger Hesse, Holger Hesse * Institut für Genbiologische Forschung GmbHIhnestraBe 63, 14195 Berlin, Germany * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Wolf B. Frommer, Wolf B. Frommer Institut für Genbiologische Forschung GmbHIhnestraBe 63, 14195 Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Lothar Willmitzer Lothar Willmitzer Institut für Genbiologische Forschung GmbHIhnestraBe 63, 14195 Berlin, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 23, Issue 16, 25 August 1995, Pages 3355–3356, https://doi.org/10.1093/nar/23.16.3355 Published: 25 August 1995 Article history Received: 31 May 1995 Accepted: 19 July 1995 Published: 25 August 1995
Bone graft substitutes for spine fusion: A brief review (2015)

Bone graft substitutes are widely used in the field of orthopedics and are extensively used to promote vertebral fusion. Fusion is the most common technique in spine surgery and is used to treat morbidities and relieve discomfort. Allograft and autograft bone substitutes are currently the most commonly used bone grafts to promote fusion. These approaches pose limitations and present complications to the patient. Numerous alternative bone graft substitutes are on the market or have been developed and proposed for application. These options have attempted to promote spine fusion by enhancing osteogenic properties. In this review, we reviewed biology of spine fusion and the current advances in biomedical materials and biological strategies for application in surgical spine fusion. Our findings illustrate that, while many bone graft substitutes perform well as bone graft extenders, only osteoinductive proteins (recombinant bone morphogenetic proteins-2 and osteogenic protein-1) provide evidence for use as both bone enhancers and bone substitutes for specific types of spinal fusion. Tissue engineered hydrogels, synthetic polymer composites and viral based gene therapy also holds the potential to be used for spine fusion in future, though warrants further investigation to be used in clinical practice.