gebhart/patrepeval huggingface dataset:
Preimplantation and prenatal genetic diagnosis of aromatic L-amino acid decarboxylase deficiency with an amplification refractory mutation system-quantitative polymerase chain reaction (2011)

To our knowledge, this is the first report of successful PGD of AADC. The molecular technique we devised (ARMS-qPCR) was applicable for PGD as well as PND of AADC. Furthermore, it has great potential for similar applications in other monogenic disorders.
Gain and Temporal Equalizer for Multi-Mode Systems (2020)

We present a device enabling individual spectro-temporal control of 15 spatial modes. Realizing independent control over both polarizations on each mode, flexible attenuation and ± 20ps of tunable delay over bandwidths exceeding 100 nm is enabled.
ChemInform Abstract: DEOXYGENATION OF 2‐HYDROXYL GROUPS IN HEXOPYRANOSIDES. USE FOR THE SYNTHESIS OF THE D‐C DISACCHARIDE GLYCOSIDE OF CHROMOMYCIN A3 (1980)

Abstract In Position 2 methylxanthogenierte Monosaccharid‐glycoside (Ia) bzw. (Ib) (im Gemisch mit dem 2,3‐Regioisomeren) lassen sich nach dem Barton‐Verfahren mit Tributylstannan (II) glatt desoxygenieren [‐ (IIIa) bzw. (IIIb) (im 2:1‐Gemisch (62%) mit dem 2‐Benzyl‐ oxy‐Isomeren)].
Design of power integrated circuits in full AlGaN/GaN MIS‐HEMT configuration for power conversion (2016)

In order to examine the feasibility of full wide‐bandgap GaN‐based converters in aerospace power conversion applications, this paper proposes a monolithic DC–DC buck converter design with integrated high‐side gate driver, over‐current protection, and pulse‐width‐modulation feedback control circuits based on full AlGaN/GaN MIS‐HEMT configuration. After model calibration of the DC and transient behaviors with fabricated normally‐ON and normally‐OFF AlGaN/GaN MIS‐HEMT devices, the DC–DC buck converter is simulated. The circuit converts the input 100 V down to an adjustable range at 1 MHz switching frequency. The over‐current protection function can properly protect the converter at a preset over‐current threshold. The converter can respond to the load current and line input voltage fluctuations due to the integrated feedback control. These results illustrate the performance of proposed all‐GaN DC–DC power converter design.
Lithium--water--air battery project: progress during the months of August--November. [Development of prototype Al/air cell] (1977)

Work done on the Lithium--Water--Air Battery Research Program in the work period August through November, 1977, is summarized. A prototype single-cell fuel cell was developed. The single galvanic cell consists of two 30-cm square aluminum plates separated by a two-faced air cathode mockup. The purposes of the model are to determine ease and cost of electrode servicing and weight and manufacturing cost of the hardware. Projections of fuel cell performance and cost were made, based on the prototype cell and the performance of cells of similar anode--cathode spacing produced by Lockheed Missiles and Space Company. Performance is a strong function of the weight of water carried in the fuel cell, as water is the limiting reactant when sufficient aluminum is carried for a vehicle range of 1600 km. Research concerning the electrochemistry of calcium in aqueous chloride--hydroxide electrolytes is summarized with reference to a recent presentation of the work at the Fall Meeting of the Electrochemical Society. Polarization curves were obtained for the aluminum alloy used by Lockheed in fuel cell research. The experimental data agree closely with Lockheed's published results. 9 figures, 1 table.
Tópicos em Educação Docência, Tecnologias e Inclusão - Volume 2 (2021)

O segundo volume da obra “Topicos em Educacao: Docencia, Tecnologias e Inclusao” traz como no primeiro volume, um eixo ligado a Educacao, com temas interligados que fazem o processo de ensino-aprendizagem acontecer de forma efetiva e eficaz, abrangendo a docencia, as tecnologias e a inclusao.
A Educacao permanece em constante movimento, evoluindo diariamente com necessidade de participacao continua de todos os envolvidos: os professores, os gestores, os estudantes, os pais e toda a comunidade escolar. A participacao de todos proporciona um processo dinâmico, integrador e capaz de mudar uma nacao.
As praticas docentes, bem como as praticas em gestao escolar contribuem para a viabilizacao do efetivo processo de ensino-aprendizagem, como nos atuais tempos de pandemia do Covid-19, que fez revolucionar a forma de ensinar, bem como aproximar as tecnologias digitais de comunicacao e informacao. Se antes da pandemia as tecnologias ja eram essenciais para o processo pedagogico, hoje sao ferramentas essenciais para docentes e discentes.
Tudo isso ainda com a missao de promover a inclusao, seja ela digital, social, cultural, bem como de alunos integrantes da Educacao Especial e Inclusiva. Promover a inclusao mais do que nunca e fator importante, de alto impacto e essencial para a Educacao que transforma, que muda vidas e leva a melhoria de um pais como um todo.
A Comparison of Disaster Management Plans for Both Japan and Myanmar (2018)

Recently, national level disaster management legislation systems have been established in Myanmar, and preparation of disaster management plans at the township level has also been encouraged. This study aims to explain these disaster management plans in Myanmar through content analysis and comparison with the Japanese Municipality Disaster Management Plan. The classification of activities by 45 categories revealed the prioritized activities in the disaster management plan for each township. Furthermore, the comparison identified differences between the disaster management plans of the two countries, of which some are explained by the difference in situations in Myanmar and Japan, but the others indicate activities missed in the township disaster management plans in Myanmar.
Extracting statistical data frames from text (2005)

We present a framework that bridges the gap between natural language processing (NLP) and text mining. Central to this is a new approach to text parameterization that captures many interesting attributes of text usually ignored by standard indices, like the term-document matrix. By storing NLP tags, the new index supports a higher degree of knowledge discovery and pattern finding from text. The index is relatively compact, enabling dynamic search of arbitrary relationships and events in large document collections. We can export search results in formats and data structures that are transparent to statistical analysis tools like S-PLUSID®. In a number of experiments, we demonstrate how this framework can turn mountains of unstructured information into informative statistical graphs.
Management Of Primary Sclerosing Cholangitis. (2006)

Management of primary sclerosing cholangitis (PSC) can be divided into endoscopic, medical, and surgical treatments. Whereas endoscopic therapy is primarily used to manage dominant strictures, medical treatment is directed both at modifying course of the disease and at symptomatic relief. Ursodeoxycholic acid is the most promising disease-modifying agent. Corticosteroids and other immunosuppressive agents do not have a proven role. Cholestyramine and rifampicin improve pruritis but response to these agents cannot be reliably predicted. Opioid antagonists are useful in refractory pruritis. All patients with advanced PSC should be offered bone mineral-density measurement and, if needed, treatment for osteoporosis. These approaches are not mutually exclusive and are often used concurrently or in sequence depending on the clinical situation. Liver transplantation is the only therapy that improves survival. In this review, we discuss the various management options for PSC.
Dependence of the Vertically Aligned Growth of Carbon Nanotubes on the Catalysts (2002)

Multiwalled carbon nanotubes were grown vertically aligned on the iron, cobalt, and nickel catalytic nanoparticles deposited on alumina substrates by thermal chemical vapor deposition of acetylene in the temperature range 900−1000 °C. The growth rate of carbon nanotubes on the iron catalyst is about 2 times higher than those on the cobalt and nickel catalysts over the temperature range. The growth rate enhances approximately by a factor of 2 for the temperature increase from 900 to 1000 °C, irrespective of the catalysts. The degree of crystalline perfection of the graphitic sheets also depends on the catalysts, which has a good correlation with the growth rates. The results suggest that the bulk diffusion of carbons would play a major role in determining the growth rate as well as the crystallinity of carbon nanotubes.
Review Biology of recently discovered cytokines: Interleukin-17 - a unique inflammatory cytokine with roles in bone biology and (2004)

IL-17 and its receptor are founding members of an emerging family of cytokines and receptors with many unique characteristics. IL-17 is produced primarily by T cells, particularly those of the memory compartment. In contrast, IL-17 receptor is ubiquitously expressed, making nearly all cells potential targets of IL-17. Although it has only limited homology to other cytokines, IL-17 exhibits proinflammatory properties similar to those of tumor necrosis factor-α, particularly with respect to induction of other inflammatory effectors. In addition, IL-17 synergizes potently with other cytokines, placing it in the center of the inflammatory network. Strikingly, IL-17 has been associated with several bone pathologies, most notably rheumatoid arthritis.
Ultrashort-pulsed laser processing with spatial and temporal beam shaping using a spatial light modulator and burst modes (2021)

Abstract We report on the effect of simultaneous spatial and temporal beam shaping on the ablation rate, ablation efficiency and the resulting surface characteristics of micromachined stainless steel using ultrashort-pulsed lasers. Beam shaping and the use of pulse bursts are promising methods to allocate the over the last decades increasing laser power of ultrashort-pulsed lasers in ablation processes. While the individual effects of beam shaping and pulse bursts on the ablation characteristics have recently been examined, the combination of both has not yet been adequately investigated. Using a spatial light modulator to generate different spot distributions with up to six spots and different separations it is possible to spatially distribute the available laser power. In combination with temporal beam shaping using a 200 kHz repetition rate and pulse bursts with a 40 MHz intra-burst rate, we investigate the influences in a scanning-based process and find an increasing ablation rate and efficiency for higher fluences. Subsequently using bursts in combination with a multi-spot beam profile, we found a distinctive emergence of cone like protrusions and a smoothing effect for fluences between 1.5 J/cm² and 3 J/cm² with six spot beam profile.
A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae (2020)

Production of an extracellular matrix is essential for biofilm formation, as this matrix both secures and protects the cells it encases. Mechanisms underlying production and assembly of matrices are poorly understood. Vibrio cholerae, relies heavily on biofilm formation for survival, infectivity, and transmission. Biofilm formation requires Vibrio polysaccharide (VPS), which is produced by vps gene-products, yet the function of these products remains unknown. Here, we demonstrate that the vps gene-products vpsO and vpsU encode respectively for a tyrosine kinase and a cognate tyrosine phosphatase. Collectively, VpsO and VpsU act as a tyrosine phosphoregulatory system to modulate VPS production. We present structures of VpsU and the kinase domain of VpsO, and we report observed autocatalytic tyrosine phosphorylation of the VpsO C-terminal tail. The position and amount of tyrosine phosphorylation in the VpsO C-terminal tail represses VPS production and biofilm formation through a mechanism involving the modulation of VpsO oligomerization. We found that tyrosine phosphorylation enhances stability of VpsO. Regulation of VpsO phosphorylation by the phosphatase VpsU is vital for maintaining native VPS levels. This study provides new insights into the mechanism and regulation of VPS production and establishes general principles of biofilm matrix production and its inhibition.
An Update High-Temperature Superconducting Maglev Measurement System (2007)

An update high temperature superconducting Maglev measurement system (SCML-02) was successfully developed. The system includes liquid nitrogen vessel, cylinder permanent magnet (PM) or PM guideway (PMG), data collection and processing, mechanical drive and autocontrol. The liquid nitrogen vessel with high temperature superconductors (HTSCs) can be placed above or under the PM. This measurement system has other characteristics: high measurement precision, instant measurement at movement of the measured HTSCs specimen, synchronous measurement of levitation and guidance, measurement in three dimensions at one time, relaxation measurement of both levitation and guidance force, and so on. In order to calibrate measurement precision and to verify special function of SCML-02, two cylinder PMs are used, which have the same scale and technical specification. The Maglev properties of HTSCs YBCO bulk are measured on the basis of the calibration results of SCML-02. The levitation forces of single YBCO bulk and of seven YBCO bulks above PMG are measured by SCML-02. All functions are validated experimentally. The main specification of the measurement system is: position precision plusmn 0.05 mm; vertical force precision 2%c; horizontal force precision 1%c. The force measurement precision has achieved 0.02 N
Data from The Proto-Oncogene ERG in Megakaryoblastic Leukemias (2023)

&lt;div&gt;Abstract&lt;p&gt;Aneuploidy is one of the hallmarks of cancer. Acquired additions of chromosome 21 are a common finding in leukemias, suggesting a contributory role to leukemogenesis. About 10% of patients with a germ line trisomy 21 (Down syndrome) are born with transient megakaryoblastic leukemia. We and others have shown acquired mutations in the X chromosome gene &lt;i&gt;GATA1&lt;/i&gt; in all these cases. The gene or genes on chromosome 21 whose overexpression promote the megakaryoblastic phenotype are presently unknown. We propose that ERG, an Ets transcription factor situated on chromosome 21, is one such candidate. We show that ERG is expressed in hematopoietic stem cells, megakaryoblastic cell lines, and in primary leukemic cells from Down syndrome patients. ERG expression is induced upon megakaryocytic differentiation of the erythroleukemia cell lines K562 and UT-7, and forced expression of ERG in K562 cells induces erythroid to megakaryoblastic phenotypic switch. We also show that ERG activates the &lt;i&gt;gpIb&lt;/i&gt; megakaryocytic promoter and binds the &lt;i&gt;gpIIb&lt;/i&gt; promoter &lt;i&gt;in vivo&lt;/i&gt;. Furthermore, both ERG and ETS2 bind &lt;i&gt;in vivo&lt;/i&gt; the hematopoietic enhancer of &lt;i&gt;SCL/TAL1&lt;/i&gt;, a key regulator of hematopoietic stem cell and megakaryocytic development. We propose that trisomy 21 facilitates the occurrence of megakaryoblastic leukemias through a shift toward the megakaryoblastic lineage caused by the excess expression of &lt;i&gt;ERG&lt;/i&gt;, and possibly by other chromosome 21 genes, such as &lt;i&gt;RUNX1&lt;/i&gt; and &lt;i&gt;ETS2&lt;/i&gt;, in hematopoietic progenitor cells, coupled with a differentiation arrest caused by the acquisition of mutations in &lt;i&gt;GATA1&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Design of all passive blocker-tolerant reconfigurable RF front-end filter (2017)

This paper presents a tunable active bandpass filter with adjustable notch close to the passband for blocker rejection. The proposed filter is based on two-path signal cancellation and consists of a top-C coupled tunable bandpass filter in parallel with an inductor. The proposed filter is implemented with high-Q N-path filter/resonator blocks in 65-nm CMOS process. The passband of the filter is tunable from 0.4 GHz to 2.2 GHz with a 3-dB bandwidth of 14.4–15.6 MHz, an insertion loss of 3.6–5.8 dB, a noise figure of 3.8–6 dB, and a total power consumption of 12.4–42 mW. Transmission zero is created close to the passband with a minimal offset of 40 MHz and are tunable across a 25 MHz range with up to 54 dB rejection. The blocker 1-dB compression point is 8.5 dBm and the out-of-band IIP3 is 23.5 dBm. The proposed filter provides a promising solution to multi-standard, multi-frequency software-defined radio applications.
Modern Uses of Electron Microscopy for Detection of Viruses (2009)

Electron microscopy, considered by some to be an old technique, is still on the forefront of both clinical viral diagnoses and viral ultrastructure and pathogenesis studies. In the diagnostic setting, it is particularly valuable in the surveillance of emerging diseases and potential bioterrorism viruses. In the research arena, modalities such as immunoelectron microscopy, cryo-electron microscopy, and electron tomography have demonstrated how viral structural components fit together, attach to cells, assimilate during replication, and associate with the cellular machinery during replication and egression. These studies provide information for treatment and vaccine strategies.
Removal of Cr(VI) from aqueous solution by coal flyash adsorption II: Kinetics of chromium adsorption on flyash (1999)

Kinetics of hexavalent chromium adsorption by flyash from aqueous solution has been studied. The results showed that the chromium removal kinetics were limited by both the binding reaction and the diffusion of species into micropores.
Supplementary Figure Legends from The TGFβ–miR200–MIG6 Pathway Orchestrates the EMT-Associated Kinase Switch That Induces Resistance to EGFR Inhibitors (2023)

&lt;p&gt;PDF file - 197KB&lt;/p&gt;
Consumption of Antarctic krill by Minke whales (1991)

The consumption of Antarctic krill ( Euphausia superba ) by an “average-sized” (male 6994 kg; female 8249 kg), sexually mature Minke whale ( Balaenoptera acutorostrata ) was estimated, from stomach capacity, ingestion rate and respiratory allometry methods. Estimates obtained from the stomach capacity and respiratory allometry methods differed by 17%–23%. An “average-sized” male Minke whale consumes 37.2 t of krill during a 90-day stay, and an “average-sized” female Minke whale consumes 56.2 t of krill during a 120-day stay, in Antarctic waters during the austral summer. It is estimated that the Minke whale population in the Antarctic (60°S and higher) consumes 35.5 × 10 6 t of krill annually.
Dynamic Modeling of Polyethylene Grade Transitions in Fluidized Bed Reactors Employing Nickel−Diimine Catalysts (2005)

Dynamic simulations of grade transitions are conducted for an industrial fluidized bed polyethylene reactor using a nickel−diimine catalyst. The reactor process model incorporates a kinetic model that predicts polymer properties for nickel−diimine ethylene polymerization. The relationships between reactor process variables and the end polymer properties are determined to be more complex than for conventional early transition-metal catalysts. In this respect, the kinetic model is demonstrated to be an effective tool for mapping out the reactor steady-state operating regions for a range of polyethylene grades and for examining process issues specific to using these catalysts. Temperature, monomer concentration, and hydrogen composition are the primary manipulated variables for achieving grade transitions in polymer density and melt index. Transitions involving changes in temperature require continual simultaneous adjustment of hydrogen and monomer feed rates to maintain the desired gas composition. Thus, where possible, it is desirable to keep the temperature constant while only changing monomer and hydrogen concentrations when making product transitions to simplify reactor operation. Quick venting and overshoot strategies are demonstrated to aid in improving product transition times. The risk of particle melting is heightened because both temperature and monomer concentration have a large influence on the branching density and the melting point of the polymer.
Sub-channel add/drop multiplexing in offset-QAM OFDM signals (2018)

We investigate the performance of an all-optical Reconfigurable Optical Add Drop Multiplexer (ROADM) architecture, that is suitable of supporting high-order regular as well as offset based QAM signals. In the proposed design, a bank of Phase Sensitive Amplifiers (PSAs) is introduced for processing offset QAM signals, while sub-channel extraction is achieved via waveform splitting and coherent subtraction. Successful performance is demonstrated for up to 32-QAM signals.
Erratum to: Use of a MAIT Activating Ligand, 5-OP-RU, as a Mucosal Adjuvant in a Murine Model of Vibrio cholerae O1 Vaccination (2022)

[This corrects the article DOI: 10.20411/pai.v7i1.525.].
Lack of interaction between tricyclic antidepressants and clonidine at the alpha2-adrenoceptor on human platelets (1982)

The pharmacologic interaction between tricyclic antidepressants and clonidine at the alpha 2-adrenoceptor was examined in human platelets by quantifying the ability of tricyclic antidepressant drugs to inhibit clonidine-stimulated platelet aggregation in vitro. Platelet aggregation induced by increasing concentrations of clonidine (0.3 to 3 microM) was not altered by pretreatment of the platelets with 10 microM imipramine. Imipramine at concentrations above 100 microM attenuated clonidine-induced platelet aggregation, but this was a nonspecific drug effect because the high concentrations of imipramine inhibited adenosine diphosphate-induced platelet aggregation as well. Desmethyldoxepin and nortriptyline also inhibited platelet aggregation nonspecifically at higher concentrations (greater than 10 microM). We were also not able to establish a specific interaction between alpha-methlnorepinephrine (the active metabolite of methyldopa) and the tricyclic antidepressants at the platelet alpha 2-adrenoceptor. Our data suggest that if there is an adverse dynamic interaction between tricyclic antidepressants and clonidine, the interaction occurs at a site other than the alpha 2-adrenoceptor.
Terror Talk and Political Management (2017)

This essay argues that the recourse to terror as the defining term of the 9/11 experience is at odds with the rhetorical choices made by Edmund Burke in his writings on the French Revolution, as well as by various Cold War theorists in the 1950s. Burke regarded terror as an incapacitating experience among its victims and sought to deny the Jacobin claim to the power of terror, which he understood to be part of their claim to control of the state. Cold War theorists were concerned to persuade the civilian population to preserve self-control and social discipline, and understood terror as threatening to both. The media projection of terror after 9/11, in contrast, worked to encourage irrational and passive responses to management from above.
Intake of different chemical species of dietary arsenic by the japanese, and their blood and urinary arsenic levels (1992)

Abstract We calculated the intake of each chemical species of dietary arsenic by typical Japanese, and determined urinary and blood levels of each chemical species of arsenic. The mean total arsenic intake by 35 volunteers was 195±235 (15.8‐1039) μg As day −1 , composed of 76% trimethylated arsenic (TMA), 17.3% inorganic arsenic (As i ), 5.8% dimethylated arsenic (DMA), and 0.8% monomethylated arsenic (MA): the intake of TMA was the largest of all the measured species. Intake of As i characteristically and invariably occurred in each meal. Of the intake of As i , 45‐75% was methylated in vivo to form MA and DMA, and excreted in these forms into urine. The mean measured urinary total arsenic level in 56 healthy volunteers was 129±92.0 μg As dm −3 , composed of 64.6% TMA, 26.7% DMA, 6.7% As i and 2.2% MA. The mean blood total arsenic level in the 56 volunteers was 0.73±0.57 μg dl −1 , composed of 73% TMA, 14% DMA and 9.6% As i . The urinary TMA levels proved to be significantly correlated with the whole‐blood TMA levels (r = 0.376; P &lt;0.01).