gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Stereoselective Synthesis of Seven‐Membered Carbocycles from 2‐Amino‐1, 3‐butadienes and Vinyl Chromium Fischer‐Type Carbenes. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Pilot Studies on Two Complementary Bath Products for Atopic Dermatitis Children: Pine-Tar and Tea (2019)

<b>Background:</b> Few standardized bath product clinical trials were performed for atopic dermatitis patients. Pine-tar and green tea extracts are plant-derived products that have been described as having anti-allergic effects which may reduce AD disease severity. <b>Methods:</b> The efficacy of two complementary bath products was studied and compared. Efficacy and acceptability of the bath products were measured by patient general acceptability of treatment (GAT: very, good, fair or poor), disease severity (SCORAD: SCoring Atopic Dermatitis), quality of life (CDLQI: Children Dermatology Life Quality Index), and pertinent clinical parameters were measured before and after four weeks of treatment. Sample size calculations for further clinical trials were performed. In one group, nine AD patients were subjected to bathing with a pine-tar bath oil for 10⁻15 min daily for four weeks. In another group, 20 AD subjects bathed with a teabag containing green tea extracts for four weeks. <b>Results:</b> Significant improvements in clinical- and patient-orientated parameters were found in the pine-tar bathing group, but not the tea-bag bathing group. Both groups reported very good/good GAT on the studied products. Teabag bathing was considered not efficacious for further clinical trials. <b>Conclusions:</b> The pilot studies provided preliminary data on the efficacy of pine tar bath oil. We do not document a significant efficacy for bathing with tea extracts. Bathing with pine-tar is potentially a complementary topical treatment with good patient acceptance and adherence, but further evidence-based research for its recommendations is needed.
Structural characterisation of doped and undoped nanocrystalline zinc oxides deposited by ultrasonic spray assisted chemical vapour deposition (2006)

Both undoped single crystal ZnO nanowires and Co-doped ZnO nanostructures with different morphology are produced using ultrasonic spray assisted chemical vapour deposition. The formation of liquid droplets due to the reducing atmosphere and the higher temperature during the nanowire growth is found to be the key step of the ZnO nanowire formation. A significant morphology evolution of the nanocrystalline Co:ZnO with both doping level and deposition temperature is observed. Some unique nanoring and nanocup shaped structures are formed in highly Co-doped films (>16%).
Neutrophil gelatinase–associated lipocalin mediates 13-cis retinoic acid–induced apoptosis of human sebaceous gland cells (2008)

13-cis retinoic acid (13-cis RA; also known as isotretinoin) is the most potent agent available for treatment of acne. It is known that the drug induces apoptosis in cells cultured from human sebaceous glands, but its mechanism of action has not been determined. In this study, skin biopsies were taken from 7 patients with acne prior to and at 1 week of treatment with 13-cis RA. TUNEL staining confirmed that 13-cis RA induced apoptosis in sebaceous glands. Transcriptional profiling of patient skin and cultured human sebaceous gland cells (SEB-1 sebocytes) indicated that lipocalin 2 was among the genes most highly upregulated by 13-cis RA. Lipocalin 2 encodes neutrophil gelatinase-associated lipocalin (NGAL), which functions in innate immune defense and induces apoptosis of murine B lymphocytes. Increased immunolocalization of NGAL was noted in patients' sebaceous glands following treatment with 13-cis RA, and recombinant NGAL induced apoptosis in SEB-1 sebocytes. Furthermore, apoptosis in response to 13-cis RA was inhibited in the presence of siRNA to lipocalin 2. These data indicate that NGAL mediates the apoptotic effect of 13-cis RA and suggest that agents that selectively induce NGAL expression in sebaceous glands might represent therapeutic alternatives to the use of 13-cis RA to treat individuals with acne.
Kaposi's Sarcoma-Associated Herpesvirus ORF57 Promotes Escape of Viral and Human Interleukin-6 from MicroRNA-Mediated Suppression (2011)

Kaposi's sarcoma-associated herpesvirus (KSHV) lytic infection increases the expression of viral and human interleukin-6 (vIL-6 and hIL-6, respectively), an important factor for cell growth and pathogenesis. Here, we report genome-wide analysis of viral RNA targets of KSHV ORF57 by a novel UV-cross-linking and immunoprecipitation (CLIP) assay. We identified 11 viral transcripts as putative ORF57 targets and demonstrate that vIL-6 mRNA is an authentic target of ORF57. Disrupting the ORF57 gene in the KSHV genome leads to inefficient expression of vIL-6. With transient transfection, the expression of vIL-6 could be enhanced greatly in the presence of ORF57 in a dose-dependent manner. We found that the open reading frame (ORF) region of vIL-6 RNA contains an MRE (MTA [ORF57]-responsive element) composed of two motifs, MRE-A and MRE-B, and binding of ORF57 to these two motifs stabilizes vIL-6 RNA and promotes vIL-6 translation. We demonstrate that vIL-6 MRE-B bears an miR-1293 binding site and that, mechanistically, ORF57 competes with miR-1293 for the same binding site to interact with vIL-6 RNA, thereby preventing vIL-6 RNA from association with the miR-1293-specified RNA-induced silencing complex (RISC). Consistent with this, ORF57 also interacts with an miR-608 binding site in the hIL-6 ORF and prevents miR-608 repression of hIL-6. Collectively, our results identify a novel function of ORF57 in being responsible for stabilization of viral and human IL-6 RNAs and the corresponding enhancement of RNA translation. In addition, our data provide the first evidence that a tumor virus may use a viral protein to interfere with microRNA (miRNA)-mediated repression of an miRNA target to induce cell proliferation and tumorigenesis during virus infection.
Editorial Comments (1983)

No AccessJournal of Urology1 May 1983Editorial Comments F. Brantley Scott F. Brantley ScottF. Brantley Scott More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)74467-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comments." The Journal of Urology, 129(5), p. 963 © 1983 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 129Issue 5May 1983Page: 963 Advertisement Copyright & Permissions© 1983 by The American Urological Association Education and Research, Inc.MetricsAuthor Information F. Brantley Scott More articles by this author Expand All Advertisement Loading ...
DeepSRGM -- Sequence Classification and Ranking in Indian Classical Music with Deep Learning (2024)

A vital aspect of Indian Classical Music (ICM) is Raga, which serves as a melodic framework for compositions and improvisations alike. Raga Recognition is an important music information retrieval task in ICM as it can aid numerous downstream applications ranging from music recommendations to organizing huge music collections. In this work, we propose a deep learning based approach to Raga recognition. Our approach employs efficient pre possessing and learns temporal sequences in music data using Long Short Term Memory based Recurrent Neural Networks (LSTM-RNN). We train and test the network on smaller sequences sampled from the original audio while the final inference is performed on the audio as a whole. Our method achieves an accuracy of 88.1% and 97 % during inference on the Comp Music Carnatic dataset and its 10 Raga subset respectively making it the state-of-the-art for the Raga recognition task. Our approach also enables sequence ranking which aids us in retrieving melodic patterns from a given music data base that are closely related to the presented query sequence.
Characterizing cortical responses evoked by electrical stimulation of the mouse infraorbital nerve (2018)

In recent years, the trigeminal nerve (CN V) has become a popular target for neuromodulation therapies to treat of a variety of diseases due to its access to neuromodulatory centers. Despite promising preclinical and clinical data, the mechanism of action of trigeminal nerve stimulation (TNS) remains in question. In this work, we describe the development and evaluation of a neural interface targeting the mouse trigeminal nerve with the goal of enabling future mechanistic research on TNS. We performed experiments designed to evaluate the ability of a peripheral nerve interface (i.e. cuff electrode) to stimulate the infraorbital branch of the trigeminal nerve. We found that both artificial and naturalistic stimulation of the trigeminal nerve elicited robust cortical responses in the somatosensory cortex that scaled with increases in stimulus amplitude. These results suggest that an infraorbital nerve interface is a suitable candidate for examining the neural mechanisms of TNS in the mouse.
Extension and Simplification of Salukvadze’s Solution to the Deterministic Nonhomogeneous LQR Problem (1998)

Abstract In a previous paper (Hampton, R. D., et al., 1996, “A Practical Solution to the Deterministic Nonhomogeneous LQR Problem,” ASME Journal of Dynamic Systems, Measurement, and Control, Vol. 118, pp. 354–360.) the authors presented a solution to the nonhomogeneous linear-quadratic-regulator (LQR) problem, for the case of known, deterministic, persistent (“non-dwindling”) disturbances. The authors used variational calculus and state-transition-matrix methods to produce an optimal matric solution, for bounded determinist forcing terms. A restricted version of this problem (treating dwindling disturbances) was evidently first investigated by Salukvadze, M. E., 1962, “Analytic Design of Regulators (Constant Disturbance),” Automation and Remote Control, Vol. 22, No. 10, Mar., pp. 1147–1155, using a differential-equations approach. The present paper uses Salukvadze’s approach to extend his work to the case of non-dwindling disturbances, with cross-weightings between state- and control vectors, and pursues the solution to the same form reported previously in Hampton et al.
Brain of myopes dealing with blur (2013)

Myopes and emmetropes present behavioural differences in presence of blur, whether in detection, tolerance and performance (Rosenfield and Abraham-Cohen, 1999). The purpose of our study was to compare the cortical response in myopes and in emmetropes when exposed to altered image resolution. We explored 38 young adults aged from 18 to 35 years including 18 emmetropes and 20 corrected myopes through functional M.R.I. at 3 Tesla. Cortical response was registered while subjects observed boards of optotypes, made of isolated Sloan letters. We add a simulated blur of 2 diopters (3.5 cycle/deg cut-off) for at least 12 second, and then images became progressively sharp. To maintain subject’s attention, the task was to detect changes in blurriness. Reaction time was recorded. Data were analysed with SPM8 package. Functional series were coregistered with anatomic data acquisition, realigned, time corrected and normalized onto MNI. At group level, a random effect was performed using an individual t-contrast (p <0.001 uncorrected). Behavioural data showed a quicker reaction for myopes than emmetropes (849ms vs. 1087ms, p=0.024). Global results showed similar responses in emmetropes and myopes in dorsal and ventral path with a predominance of the right hemisphere. Statistical comparison showed mild but significant differences between the two groups, the myopes presenting more activation in right middle temporal (BA21, 12 voxels, F=10.11), left putamen (5 voxels, F=8.57), right caudate nucleus (5 voxels, F=8.51) and right superior frontal area (5 voxels, F=8.09) when compared to emmetropes. The predominance of right hemisphere might be linked with a specialisation for low spatial frequencies (Peyrin et al., 2010). Differences between two groups suggest a cortical adaptation in myopes in accordance with a fastest detection of blur variation, recruiting supplementary areas distant from occipital lobe to enhance altered image perception. Meeting abstract presented at VSS 2013
Engineering a switchable toxin: the potential use of PDZ domains in the expression, targeting and activation of modified saporin variants (2009)

A critical problem in studying ribosome-inactivating proteins (RIPs) lies in the very limited possibility to produce them in heterologous systems. In fact, their inherent toxicity for the producing organism nearly always prevents their recombinant expression. In this study, we designed, expressed and characterized an engineered form of the RIP saporin (SapVSAV), bearing a C-terminal extra sequence that is recognized and bound by the second PDZ domain from murine PTP-BL protein (PDZ2). The co-expression of SapVSAV and PDZ2 in Escherichia coli BL21 cells greatly enhances the production of the toxin in a soluble form. The increase of production was surprisingly not due to protection from bacterial intoxication, but may arise from a stabilization effect of PDZ2 on the toxin molecule during biosynthesis. We found that once purified, SapVSAV is stable but is not toxic to free ribosomes, while it is fully active against human cancer cells. This strategy of co-expression of a toxin moiety and a soluble PDZ domain may represent a new system to increase the production of recombinant toxic proteins and could allow the selection of new extra sequences to target PDZ domains inside specific mammalian cellular domains.
Broadband microstrip patch antenna for wireless applications (1998)

In this paper, broadband patch microstrip antenna is investigated. The goal is to meet the demands on wireless communication systems where there is a substantial need for new antennas, which are light, low profile and low cost. Microstrip patch antenna constitutes a best candidate in this area. However, these antennas are characterized by the limitation of their bandwidth that is of order 1–2%. In wireless system, this band is not enough sufficient for a high rate data transmission. To overcome this problem, a new antenna is presented in this paper.
Excess Genetic Baggage Dumped (1991)

In recent years, putting new genes into plants has become routine, as plant scientists have genetically engineered a wide variety of plant strains having novel genes that help them resists pests and disease, improve their nutritional properties, and produce drugs and industrial enzymes. Not widely appreciated, however, is the fact that all those genes have been introduced into the plants in combination with so-called marker genes, usually encoding for antibiotic or herbicide resistance, that are used as laboratory tools to select the few plants that have acquired the novel genes from the many that have not. The genetic engineers had previously been unable to remove the marker genes, but now scientists have come up with a new version of the gene transfer procedure that allows the marker genes to be expunged after plants have acquired the desired genes.
Precursors of Solvated Electrons in Radiobiological Physics and Chemistry (2012)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTPrecursors of Solvated Electrons in Radiobiological Physics and ChemistryElahe Alizadeh and Léon Sanche*View Author Information Groupe en Sciences des Radiations, Département de Médecine Nucléaire et Radiobiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, J1H 5N4 Sherbrooke, Canada*E-mail: [email protected]Cite this: Chem. Rev. 2012, 112, 11, 5578–5602Publication Date (Web):June 22, 2012Publication History Received15 February 2012Published online22 June 2012Published inissue 14 November 2012https://pubs.acs.org/doi/10.1021/cr300063rhttps://doi.org/10.1021/cr300063rreview-articleACS PublicationsCopyright © 2012 American Chemical SocietyRequest reuse permissionsArticle Views4899Altmetric-Citations309LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anions,Electrical energy,Genetics,Molecules,Radiation Get e-Alerts
Piezoelectric Nanowires in Energy Harvesting Applications (2015)

Recently, the nanogenerators which can convert the mechanical energy into electricity by using piezoelectric one-dimensional nanomaterials have exhibited great potential in microscale power supply and sensor systems. In this paper, we provided a comprehensive review of the research progress in the last eight years concerning the piezoelectric nanogenerators with different structures. The fundamental piezoelectric theory and typical piezoelectric materials are firstly reviewed. After that, the working mechanism, modeling, and structure design of piezoelectric nanogenerators were discussed. Then the recent progress of nanogenerators was reviewed in the structure point of views. Finally, we also discussed the potential application and future development of the piezoelectric nanogenerators.
The SOLAR algorithm (1994)

We propose SOLAR (supervised one-shot learning algorithm for real number inputs). SOLAR requires only a single presentation of real number input data, so it can learn very quickly compared to the backpropagation algorithm (BP). We introduce a new similarity matrix which measures Euclidean distance of the training set. From the topology of the similarity matrix, the structure of network, learning parameters and linear threshold functions are determined. Since it uses the structural method, SOLAR is suited to the dynamic environment, e.g. addition or subtraction of training instances, input units and output units. The main contribution of this paper is that SOLAR can handle analog inputs, so it can be easily extended to learning temporal sequences and improve the ability of the generalization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The antibacterial potential of the seaweeds (Rhodophyceae) of the Strait of Gibraltar and the Mediterranean Coast of Morocco (2014)

The antibacterial activity of extracts from 26 marine Rhodophyceae (8 Ceramiales, 7 Gelidiales, 9 Gigartinales, 1 Bonnemaisoniales and 1 Rhodymeniales) was studied to assess their potential in the pharmaceutical industry. Their bioactivity was analysed from crude methanolic extracts of dried samples against three gram-positive bacteria and two gram-negative bacteria using the disc diffusion technique. The samples were collected from Gibraltar and the Moroccan Mediterranean coast. Of the macroalgae analysed, 96% of extracts were active against at least one of the five test microorganisms. Staphylococcus aureus was the most susceptible microorganism. Methanolic extracts of all seaweed extracts tested in the present study exhibited a broad spectrum of antibacterial activity with inhibition diameters ranging from 10 to 35 mm. An extract of Hypnea musciformis exhibited high antibacterial activity against all the bacteria tested. The results of the present study confirmed the potential use of seaweed extracts as a source of antibacterial compounds.
A New Light for Berkeley Lab—the Advanced Light Source Upgrade (2019)

The Advanced Light Source Upgrade Project (ALS-U) will leverage multibend achromat technology to endow the ALS with revolutionary soft X-ray capabilities, and has recently received formal approval to proceed to the preliminary design phase. Soft X-rays are a critical diagnostic tool for enabling the understanding and control of heterogeneous, hierarchical functional materials and chemical synthesis platforms since they can reveal chemical, electronic, and magnetic properties with very high sensitivity. Although the ALS has a strong track record in soft X-ray science over the last 25 years, it, like most other existing storage-ring-based X-ray light sources, lacks the simultaneous combination of nanometer spatial resolution, diverse spectroscopic contrast, and broad temporal sensitivity required to image the location of molecules, ions, and electrons, and to measure how their components migrate and interact to support efficient function. The high coherent flux of the upgraded ALS willenable a suite of tools that encompass 3D nanoscale imaging with high spectral sensitivity over broad space and time scales, dramatically amplifying the already high impact of ALS soft X-ray spectroscopies. Relative to many other synchrotron light source upgrade projects or new facilities being built today, the upgraded ALS will operate at a low electron-beam energy of 2 GeV and a high current of 500 mA, and is optimized for soft X-rays. Its soft X-ray coherent flux will be orders of magnitude higher than that of the existing ALS and beyond the coherent flux of any storage-ring-based light source operating, under construction, or currently planned. In total, the upgraded facility will provide an unprecedented combination of high stability, quasi-continuous radiation, and the highest possible coherent soft X-ray flux.
Formation of N‐Doped Carbon‐Coated ZnO/ZnCo2O4/CuCo2O4 Derived from a Polymetallic Metal–Organic Framework: Toward High‐Rate and Long‐Cycle‐Life Lithium Storage (2017)

Metal-organic frameworks (MOFs) are very promising self-sacrificing templates for the large-scale fabrication of new functional materials owing to their versatile functionalities and tunable porosities. Most conventional metal oxide electrodes derived from MOFs are limited by the low abundance of incorporated metal elements. This study reports a new strategy for the synthesis of multicomponent active metal oxides by the pyrolysis of polymetallic MOF precursors. A hollow N-doped carbon-coated ZnO/ZnCo<sub>2</sub> O<sub>4</sub> /CuCo<sub>2</sub> O<sub>4</sub> nanohybrid is prepared by the thermal annealing of a polymetallic MOF with ammonium bicarbonate as a pore-forming agent. This is the first report on the rational design and preparation of a hybrid composed of three active metal oxide components originating from MOF precursors. Interestingly, as a lithium-ion battery anode, the developed electrode delivers a reversible capacity of 1742 mAh g<sup>-1</sup> after 500 cycles at a current density of 0.3 mA g<sup>-1</sup> . Furthermore, the material shows large storage capacities (1009 and 667 mAh g<sup>-1</sup> ), even at high current flow (3 and 10 A g<sup>-1</sup> ). The remarkable high-rate capability and outstanding long-life cycling stability of the multidoped metal oxide benefits from the carbon-coated integrated nanostructure with a hollow interior and the three active metal oxide components.