gebhart/patrepeval huggingface dataset:
Expert-Finding Systems for Organizations: Problem and Domain Analysis and the DEMOIR Approach (2003)

Abstract Computer systems that augment the process of finding, in an organization or worldwide, the appropriate expert for a given problem are becoming more feasible than ever as a result of the prevalence of corporate intranets and the Internet. In this article, we investigate such systems in 2 parts. First, we explore the expert-finding problem in depth, review and analyze existing systems in this domain, and suggest a domain model that can serve as a framework for design and development decisions. Second, on the basis of our analyses of the problem and solution spaces, we bring to light the gaps that remain to be addressed. Finally, after this two-part investigation, we present our approach, called DEMOIR (dynamic expertise modeling from organizational information resources), which is a modular architecture for expert-finding systems that is based on a centralized expertise-modeling server but also incorporates decentralized components for expertise information gathering and exploitation.
Covalent-Fragment Screening of Brd4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites (2019)

Brd4, a member of the bromodomain and extraterminal domain (BET) family, has emerged as a promising epigenetic target in cancer and inflammatory disorders. All reported BET family ligands bind within the bromodomain acetyl-lysine binding sites and competitively inhibit BET protein interaction with acetylated chromatin. Alternative chemical probes that act orthogonally to the highly-conserved acetyl-lysine binding sites may exhibit selectivity within the BET family and avoid recently reported toxicity in clinical trials of BET bromodomain inhibitors. Here, we report the first identification of a ligandable site on a bromodomain outside the acetyl-lysine binding site. Inspired by our computational prediction of hotspots adjacent to non-homologous cysteine residues within the C-terminal Brd4 bromodomain (Brd4-BD2), we performed a mid-throughput mass spectrometry screen to identify cysteine-reactive fragments that covalently and selectively modify Brd4. Subsequent mass spectrometry, NMR and computational docking analyses of electrophilic fragment hits revealed a novel ligandable site near Cys356 that is unique to Brd4 among all human bromodomains. This site is orthogonal to the Brd4-BD2 acetyl-lysine binding site as Cys356 modification did not impact binding of the pan-BET bromodomain inhibitor JQ1 in fluorescence polarization assays. Finally, we tethered covalent fragments to JQ1 and performed NanoBRET assays to provide proof of principle that this orthogonal site can be covalently targeted in intact human cells. Overall, we demonstrate the potential of targeting sites orthogonal to bromodomain acetyl-lysine binding sites to develop bivalent and covalent inhibitors that displace Brd4 from chromatin.
Efficacy and Safety of Surgery for Benign Prostatic Obstruction in Patients with Preoperative Urinary Catheter (2020)

<b><i>Purpose:</i></b> To evaluate the efficacy and safety of benign prostatic obstruction (BPO) surgery in patients with preoperative urinary catheterization. <b><i>Patients and Methods:</i></b> We conducted a multi-institutional retrospective study including all patients who failed a trial without catheter (TWOC) after acute urinary retention (AUR) between January 2017 and January 2019. Patients with neurogenic bladder, prostate cancer, or urethral stricture were excluded from the analysis. Patients underwent either monopolar/bipolar transurethral resection of the prostate (TURP), photoselective vaporization of the prostate (PVP), prostate artery embolization (PAE), open prostatectomy (OP), or endoscopic enucleation. The primary endpoint was 12-month urinary catheter-free survival without using benign prostatic hyperplasia medications. <b><i>Results:</i></b> One hundred seventy-one consecutive men (median age: 71 years; median prostate volume: 75 cm<sup>3</sup>) underwent BPO surgery, including 48 (28%) TURP, 62 (36.3%) PVP, 21 (12.3%) endoscopic enucleation, 15 (8.8%) PAE, and 25 (14.6%) OP. The median duration of preoperative urinary catheterization was 69 days (interquartile range 46-125). The 12-month urinary catheter-free survival rate was 84.8% (145/171). Satisfactory voiding returned to 121 patients (70.8%). On backward stepwise multivariable analysis, PVP (odds ratio [OR] 0.27 [0.10-0.69]; <i>p</i> = 0.008), PAE (OR 5.27 [1.28-27.75]; <i>p</i> = 0.03), endoscopic enucleation (OR 0.08 [0-0.49]; <i>p</i> = 0.023), OP (OR 0.10 [0.01-0.57]; <i>p</i> = 0.034), Charlson score (OR 1.36 [1.14-1.66]; <i>p</i> = 0.001), and number of preoperative TWOC failure (OR 2.53 [1.23-5.51]; <i>p</i> = 0.014) were significantly associated with catheter-free survival. <b><i>Conclusions:</i></b> In this multi-institutional retrospective study, including patients with preoperative catheterization, the overall success rate of BPO surgery was 70.8% after 1-year follow-up. Compared with TURP, enucleation methods and PVP were associated with better catheter-free survival, whereas PAE was associated with higher risk of AUR recurrence.
Pro-active service robots in a health care framework: vocal interaction using natural language and prosody (2002)

This paper describes a service robotics application in a health care environment. Human-robot interaction is based on the integration of low level skills like acoustic localization of noise/voice sources with high level competencies like continuous speech recognition and prosody based dialogue. A multirobotic system is presented; its coordination is performed by a central supervision device which manages the vocal interaction with a number of human operators. A microphone array placed on the top of the robots is used both for near talker location and for auto-localization through acoustic beacons. Preliminary experimental results are discussed.
Loss of transporter in antigen processing 1 transport protein and major histocompatibility complex class I molecules in metastatic versus primary breast cancer. (1995)

We studied by immunohistochemistry the HLA-allelic, beta 2-microglobulin, and TAP-1 expression in primary breast carcinomas and related lymph node metastases. Thirty-three of the primary tumors and 44% of the lymph node metastases had a complete HLA class I loss. The higher incidence of antigenic loss in metastatic tumors suggests that recognition of HLA class I antigens by the host immunity could have an important role in the metastatic evolution of breast cancer. We observed a simultaneous defective expression of all three components involved in HLA class I expression. Since the controlling genes of heavy chain and TAP-1 are located in different chromosome than beta 2-microglobulin, it could be that a common factor exists regulating HLA class I antigenic expression. Five of 25 (20%) primary and metastatic tumors from HLA-A2-positive individuals also had a selective loss. The high incidence of HLA class I loss in breast cancer patients shows that adjuvant immunotherapy to induce HLA class I expression could be of value in a subgroup of patients.
AUTONOMOUS AUTOMATED DRIVING IN REAL TRAFFIC (1994)

Within the PROMETHEUS (PROgraMme for a European Traffic with Highest Efficiency and Unprecedented Safety) activities, the increase of safety plays an important role. One solution consists in environment detection and derivation of the appropriate driving manoeuvres in order to avoid collisions automatically. In this paper the autonomous automated driving demonstrator vehicle VITA II (VIsion Technology Application) is presented. The driving manoeuvres performed by VITA II such as line keeping, lane changing, overtaking and collision avoidance are listed. The perception modules required to carry out these manoeuvres are also presented briefly. (A) For the covering abstract see IRRD 868006.
Allograft prosthetic composite replacement for bone tumors (1997)

Limb salvage for bone tumors has become the standard method of treatment. This technique involves removal of large segments of bone, most commonly around the hip and knee. Various types of reconstructive options are currently available, including osteoarticular allograft arthroplasty, modular oncology prosthetic arthroplasty, allograft prosthetic composite (APC) arthroplasty, and arthrodesis. Compared to other techniques, APC arthroplasty has many advantages, including restoration of bone stock, customization with conventional implant components, soft tissue attachment of tendons and ligaments, and preservation of the medullary canal of the host bone. The disadvantages of this technique include slow healing in the presence of chemotherapy, the possibility of disease transmission, and availability. The technique is suited either for aggressive benign tumors or for low-grade sarcomas where chemotherapy is not necessary. Further, it represents a good alternative for a failed modular oncology prosthesis, and also for the failed osteoarticular allograft because it restores bone stock. Good functional results have been reported with APC replacements, but long-term follow-up is needed to determine their durability. Semin. Surg. Onc. 13:18–24. © 1997 Wiley-Liss, Inc.
The production of non hydrocarbon-derived methanol, ethanol and their butyl ethers from biomass and butanes using the MOP process (1993)

The proprietary MOP (Multiple Oxygenates Production) Process, covered by US Patent {number_sign}5,070,016 which was granted in December 1991, offers an unique approach to the production of ethanol, methanol and their t-butyl ethers within the same operating facility. The MOP Process uses fully commercialized process operations to convert grain (or other biomass) and butanes to ethanol, methanol and their ether derivatives in a fully integrated complex, either as a standalone, grass roots project or integrated with an existing ethanol fermentation facility, petroleum refinery or petrochemical complex. Key to the MOP Process is the production of non hydrocarbon-derived methanol from carbon dioxide that is normally vented from the ethanol fermentation process plus by-product hydrogen from the butane dehydrogenation process (or other external source). In most cases, the methanol is produced entirely from the offgas streams rather than from natural gas, the preferred raw material for the production of most conventional methanol. The integrated MOP Process is highly flexible, especially in terms of its finished product slate, and offers significant cost advantages for the production of MtBE and EtBE from the basic grain and butane raw materials, compared to conventional ether production methods which typically rely on purchased alcohol raw materials. Overall costmore » advantages for the production of methanol from biomass-derived carbon dioxide and by-product hydrogen are 42--48 cents/USgal, or 14--16 cents/USgal of MtBE equivalent.« less
Amorphous Ni–Ti and Ni–Zr Alloys for Water Electrolysis Cathode Materials (1983)

Abstract Amorphous Ni–Ti and Ni–Zr alloys for their possible use in water electrolysis cathode materials were investigated. The hydrogen electrode reaction in 1 M NaOH (1 M= 1 mol dm−3) proceeds via the Volmer-Tafel reaction route with mixed rate-determining characteristics. The electrocatalytic activity is augmented significantly with a treatment of the alloy electrodes with aq HF. Thus, the exchange current density reaches 10−3A cm−2 (apparent) at 303 K. The activation energy values are 9.4, 5.5, and 6.1 kcal mol−1 (1 cal=4.184J) for the Volmer and Tafel step and the overall reaction, respectively. Surface analyses of the electrodes have indicated that such a high activity is caused by a stable porous Ni layer which is formed on the surface by the acid treatment. Such a porous Ni layer was not effectively formed if the alloys were in crystalline states.
Interacting Proteins Identified by Genetic Interactions: a Missense Mutation in α-Tubulin Fails to Complement Alleles of the Testis-Specific β-Tubulin Gene of Drosophila melanogaster (1989)

In this paper we demonstrate that failure to complement between mutations at separate loci can be used to identify genes that encode interacting structural proteins. A mutation (nc33) identified because it failed to complement mutant alleles of the gene encoding the testis-specific beta 2-tubulin of Drosophila melanogaster (B2t) did not map to the B2t locus. We show that this second-site noncomplementing mutation is a missense mutation in alpha-tubulin that results in substitution of methionine in place of valine at amino acid 177. Because alpha- and beta-tubulin form a heterodimer, our results suggest that the genetic interaction, failure to complement, is based on the structural interaction between the protein products of the two genes. Although the nc33 mutation failed to complement a null allele of B2t (B2tn), a deletion of the alpha-tubulin gene to which nc33 mapped complemented B2tn. Thus, the failure to complement appears to require the presence of the altered alpha-tubulin encoded by the nc33 allele, which may act as a structural poison when incorporated into either the tubulin heterodimer or microtubules.
A Model of Decentralized Social Internet of Things using Blockchain Offline Channels (2020)

Social Internet of Things (SIoT) enables IoT devices to discover the services offered by each other using a social network. The social network connects two devices if they have a common owner or both manufactured by the same company or they are situated at the same location etc. Centralized SIoT platforms have security and privacy problems. We advance the state of art in SIoT as we have developed a decentralized SIoT platform. In a decentralized SIoT platform, the services provided by a device is only known to its neighbours. Due to such characteristics of decentralized SIoT platform, there are several challenges in designing it, such as verification of social neighbourhood, privacy-preserving search in SIoTs, and scalability of SIoT platform. In this paper, we propose a blockchain-based SIoT platform to mitigate these problems. Our main contributions are: We developed a decentralized SIoT platform that allows secure privacy-preserving method to verify social neighbourhood a device, we developed a protocol to find devices in the decentralized SIoT and we developed a high scale decentralized SIoT platform using blockchain offline channels. We prove the proposed decentralized SIoT platform is privacy-preserving, secure, and scalable.
Laser Warning Receiver (1996)

Abstract : In the last 20 years, the applications of lasers in military affairs have grown wider by the day. Laser range finding causes the first round hit probability for guns to very, very greatly increase. Laser guidance then increases in an extremely large way weapon launch precisions and hit probabilities. Cost benefit ratios are very high. The combat power of U.S. military forces has already improved an order of magnitude relying on these small energy laser systems. How should fire control systems having laser range finding and laser guided weapons systems be handled? This simply requires timely discovery of the laser operations of the hostile side. Laser warning receivers are the basic materiel for implementing laser countermeasures. Their role is to detect in a timely and accurate manner enemy laser range finders, laser radiation emited from such things as target indicators, laser beam guidance illumination devices, and so on, to send out warnings, and to make notification of certain types of weapons of a threatening nature (for example, artillery shells, bombs, or missiles) having a possibility of coming in immediately, in order to facilitate the adoption in a timely manner of friendly emergency measures, or evasion, or the laying of smoke screen aersols to protect themselves, or to notify associated weapons systems (for example, guns or laser blinding weapons, and so forth) to implement countermeasures. As a result, laser warning receivers are very significant with regard to effectively protecting oneself and destroying the enemy on the battlefield.
Activation of Phosphatidylinositol 3-Kinase in Cells Expressing abl Oncogene Variants (1991)

A phosphoinositide kinase specific for the D-3 position of the inositol ring, phosphatidylinositol (PI) 3-kinase, associates with activated receptors for platelet-derived growth factor, insulin, and colony-stimulating factor 1, with products of the oncogenes src, fms, yes, crk, and with polyomavirus middle T antigen. Efficient fibroblast transformation by proteins of the abl and src oncogene families requires activation of their protein-tyrosine kinase activity and membrane association via an amino-terminal myristoylation. We have demonstrated that the PI 3-kinase directly associates with autophosphorylated, activated protein-tyrosine kinase variants of the abl protein. In vivo, this association leads to accumulation of the highly phosphorylated products of PI 3-kinase, PI-3,4-bisphosphate and PI-3,4,5-trisphosphate, only in myristoylated, transforming abl protein variants. Myristoylation thus appears to be required to recruit PI 3-kinase activity to the plasma membrane for in vivo activation and correlates with the mitogenicity of the abl protein variants.
Engineering electroactive scaffolds for neural regeneration applications (2016)

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Comparison of pMOS and nMOS 28 GHz high efficiency linear power amplifiers in 45 nm CMOS SOI (2018)

High efficiency, compact CMOS power amplifiers (PAs) based on nMOS and pMOS transistors in 45 nm CMOS SOI technology for Ka-band applications are presented. Both the nMOS and pMOS amplifiers use 2-stack power devices in order to increase the maximum output voltage swing. Both the nMOS and pMOS PAs have peak small signal gain of about 13 dB, and demonstrate more than 40% peak PAE, with 18.9 dBm saturated output power for the nMOS and 17.8 dBm for the pMOS (when measured at the same drain bias voltage.) With a 64-QAM OFDM signal with 800MHz bandwidth, the nMOS PA achieves EVM = 5.5% with average output power of P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> = 9.8 dBm and average PAE = 14.8%. We show that the pMOS amplifiers are able to withstand higher drain bias voltages than their nMOS counterparts. The amplifiers have compact dimensions and occupy 0.18 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> of active area.
Flow Channel Influence of a Collision-Based Piezoelectric Jetting Dispenser on Jet Performance (2018)

To improve the jet performance of a bi-piezoelectric jet dispenser, mathematical and simulation models were established according to the operating principle. In order to improve the accuracy and reliability of the simulation calculation, a viscosity model of the fluid was fitted to a fifth-order function with shear rate based on rheological test data, and the needle displacement model was fitted to a nine-order function with time based on real-time displacement test data. The results show that jet performance is related to the diameter of the nozzle outlet and the cone angle of the nozzle, and the impacts of the flow channel structure were confirmed. The approach of numerical simulation is confirmed by the testing results of droplet volume. It will provide a reliable simulation platform for mechanical collision-based jet dispensing and a theoretical basis for micro jet valve design and improvement.
Projection photolithography by wave-front conjugation (1981)

Conjugate wave-front generation by degenerate four-wave mixing has been employed to project images with submicrometer features onto photoresist-coated substrates. The developed patterns demonstrate a resolution of &gt;800 line pairs per millimeter for 413-nm illumination, consistent with theoretical expectations. The patterns are not degraded by speckle or edge enhancement, and the magnification is within 0.1% of unity. Focusing is accomplished by a novel interferometric procedure.
Transition Metal Hydrazide‐Based Hydrogen‐Storage Materials: the First Atoms‐In‐Molecules Analysis of the Kubas Interaction (2012)

Molecular models of the M-H(2) binding sites of experimentally characterised amorphous vanadium hydrazide gels are studied computationally using gradient corrected density functional theory, to probe the coordination number of the vanadium in the material and the nature of the interaction between the metal and the H(2) molecules. The H(2) is found to bind to the vanadium through the Kubas interaction, and the first quantum theory of atoms-in-molecules analysis of this type of interaction is reported. Strong correlation is observed between the electron density at the H-H bond critical point and the M-H(2) interaction energy. Four coordinate models give the best reproduction of the experimental data, suggesting that the experimental sites are four coordinate. The V-H(2) interaction is shown to be greater when the non-hydrazine based ligand, THF, of the experimental system is altered to a poorer π-acceptor ligand. Upon altering the metal to Ti or Cr the M-H(2) interaction energy changes little but the number of H(2) which may be bound decreases from four (Ti) to two (Cr). It is proposed that changing the metal from V to Ti may increase the hydrogen storage capacity of the experimental system. A 9.9 wt% maximum storage capacity at the ideal binding enthalpy for room temperature performance is predicted when the Ti metal is combined with a coordination sphere containing 2 hydride ligands.
Modelling melting and grain destruction phenomena during globular equiaxed solidification (2021)

Melting or re-melting accompanies solidification in many technical castings. For example, during ingot casting, some crystal fragments or equiaxed grains can enter the superheated region and re-melt, while solidification continues in other regions. Solidification and remelting occurring simultaneously at different locations present an important species/energy transport mechanism, which impacts the structural/compositional homogeneity of the castings. The re-melting is typically understood as a reduction in the equiaxed grain size, but it can also lead to the destruction (disappearance) of equiaxed grains. Existing process-based models cannot treat the solidification/melting by considering both grain nucleation and destruction properly. Therefore, a new model is proposed based on a two-phase volume-average approach. In this model, nucleation of equiaxed grains occurs when inoculants (free growth sites) are activated by undercooling, while destruction of equiaxed grains occurs only when the equiaxed grains are completely re-melted by superheating. The mass, momentum, species, and enthalpy conservation equations are solved for the solidification/melting. The transport equations for the number densities of equiaxed grains and inoculants are calculated separately. A test casting (Al–7 wt.% Si) is calculated to illustrate the modelling features. This study improves understanding of grain melting and grain destruction as well as their impact on the as-solidified structure.
Application Layer Mobility over IPv6 Using Layer 2 Triggers (2004)

This paper describes a solu tion for the optimization of Session Initiation Protocol (SIP) based mobility over IPv6 in an 802.lIb network as well as its theoretical evaluation and actual performance. Time necessary for a complete handoff depends on multiple factors. In this paper we focus on the delay accumulated during movement detection and try to bring it to a minimum using upward propagation of events generated by a Layer 2 entity. This allows us to speed up handoffs and get closer to a mobility solution applicable in real-world communications. We are using SIP both as a communications signalling protocol and as a means of handling application layer terminal mobility.