gebhart/patrepeval huggingface dataset:
Effects of 12-Week Ingestion of Yogurt Containing Lactobacillus plantarum OLL2712 on Glucose Metabolism and Chronic Inflammation in Prediabetic Adults: A Randomized Placebo-Controlled Trial (2020)

The ingestion of <i>Lactobacillus plantarum</i> OLL2712 (OLL2712) cells improved glucose metabolism by suppressing chronic inflammation in mouse models and in a preliminary clinical study. We aimed to clarify the effect of OLL2712 on glucose metabolism and chronic inflammation for healthy adults. Prediabetic adults (<i>n</i> = 130, age range: 20-64 years) were randomly assigned to either the placebo or OLL2712 groups (<i>n</i> = 65 each) and were administered conventional yogurt or yogurt containing more than 5 × 10<sup>9</sup> heat-treated OLL2712 cells, respectively, daily for 12 weeks. Reduced HbA1c levels after 12 weeks of treatment were observed in both groups compared to those at baseline; however, the 12-week reduction of HbA1c levels was significantly greater in the OLL2712 group than in the placebo group. Increased chronic inflammation marker levels and insulin-resistant index (HOMA-IR) occurred in the placebo group but not in the OLL2712 group. Fasting blood glucose (FBG) levels did not change significantly in both groups; however, in subgroup analyses including participants with higher FBG levels, FBG levels were significantly reduced only in the OLL2712 group compared to baseline. These results suggest that OLL2712 cell ingestion can reduce HbA1c levels and can prevent the aggravation of chronic inflammation and insulin resistance.
Preparative bioorganic chemistry, XV. Preparation of optically pure 2,4,4‐trimethyl‐2‐cyclohexen‐1‐ol, a new and versatile chiral building block in terpene synthesis (1991)

Abstract Enzymatic hydrolysis of (±)‐2,4,4‐trimethyl‐2‐cyclohexenyl acetate [(±)‐ 3 ] with pig liver esterase yielded ( R )‐(+)‐2,4,4‐trimethyl‐2‐cyclohexen‐1‐ol [( R )‐ 2 ] and unchanged ( S )‐(−)‐acetate ( S )‐ 3 . Enantiomerically pure ( S )‐ 2 was converted into ( R )‐dihydro‐α‐ionone ( 10 ).
Separation and detection of low concentrations of polythionates by high speed anion exchange liquid chromatography (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeparation and detection of low concentrations of polythionates by high speed anion exchange liquid chromatographyAaron W. Wolkoff and Richard H. LaroseCite this: Anal. Chem. 1975, 47, 7, 1003–1008Publication Date (Print):June 1, 1975Publication History Published online1 May 2002Published inissue 1 June 1975https://pubs.acs.org/doi/10.1021/ac60357a009https://doi.org/10.1021/ac60357a009research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Advanced engineering materials at high temperatures (2014)

Materials that are available at the present time for use as engineering components are highly limited in their performance at temperatures above about 1000°C in corrosive environments. There is probably no satisfactory material for service in air above 1400°C and there is only a restricted selection of materials in view including silicon nitride based materials, silicon carbide based materials, and carbon–carbon–silicon carbide composites. This article summarizes the findings of several recent workshops concerned with high–temperature engineering ceramics, and covers nitrogen ceramics, ceramic–ceramic composites, ceramic coatings, Zr02–based ceramics, non–oxide ceramics, ceramic toughening mechanisms, and the microstructure and processing of engineering ceramics. Progress towards improved ceramic properties is not automatic, and many severe problems remain. Developments are needed in: oxidation resistant coatings for carbon–carbon composites, and for super alloys; particulate dispersants of controlled morphology suitable for Si3N4–based and SiC–based materials; high–stability fibres with non–reactive interfaces in refractory matrices; sintering mechanisms of monolithic and of composite ceramics; other high–temperature materials such as borides, silicides, carbides; detection of small flaws in ceramics; data on the mechanical properties of ceramics at temperatures above 1400°C; other methods of preparation of ceramic microstructures; ceramic toughening mechanisms and their interactions.
Multiple structures of adeno-associated virus DNA: analysis of terminally labeled molecules with endonuclease R-Hae III (1976)

The double-stranded form of adeno-associated virus (AAV) DNA has about 20 sites sensitive to endonuclease R.Hae III from Haemophilus aegypitus; the fragments produced fall into about 13 size classes, 8 of which contain single fragments. The location of the Hae III-produced AAV fragments relative to the three EcoR1 fragments was determined. Using revised figures for the molecular weights of the Hae III cleavage products of phiX174 replicative form DNA, we calculated that AAV DNA contains about 4,000 nucleotides. After Hae III digestiion of duplex DNA terminally labeled with 32P using polynucleotide kinase, the majority of fragments containing a 5' 32P label were about 40 nucleotides in length, and fragments of similar size were generated from each end, suggesting that the Hae site closest to the end is within the terminal repetition. Two more-slowly-migrating cleavage products also bore 5' 32P end label. These three terminally labeled species were also generated from single-stranded AAV DNA by digestion with Hae III, and evidence that one may have a nonlinear ("rabbit-ear") structure is presented. The predominant 5' terminal base was identified as thymine for both the plus and minus strands of AAV. Single-stranded AAV molecules could not be efficiently covalently circularized by incubation with polynucleotide ligase or ligase plus T4 DNA polymerase.
Antidiabetic drugs influence molecular mechanisms in prostate cancer (2018)

We did not find a connection between antidiabetic drugs and PCa aggressiveness or progression. However, tumor biology seems to be different among patients with and without antidiabetic drugs.
Recent Advances in Iridium-catalyzed Organic Synthesis (2007)

Transition metal complexes play an important role in modern organic synthesis, because they can realize useful transformations that would be either difficult or impossible by conventional organic chemistry. Organic synthesis with iridium was far behind that with rhodium, ruthenium and palladium in the early 1990 s. However, many useful reactions catalyzed by iridium have been reported today. This review focuses on enantioselective hydrogenation of unfunctionalized alkenes, allylic substitution, cycloaddition, cycloisomerization, carbonylation and aldol reaction.
Zn2+ selectively stabilizes FdU-substituted DNA through a unique major groove binding motif (2011)

We report, based on semi-empirical calculations, that Zn(2+) binds duplex DNA containing consecutive FdU-dA base pairs in the major groove with distorted trigonal bipyramidal geometry. In this previously uncharacterized binding motif, O4 and F5 on consecutive FdU are axial ligands while three water molecules complete the coordination sphere. NMR spectroscopy confirmed Zn(2+) complexation occurred with maintenance of base pairing while a slight hypsochromic shift in circular dichroism (CD) spectra indicated moderate structural distortion relative to B-form DNA. Zn(2+) complexation inhibited ethidium bromide (EtBr) intercalation and stabilized FdU-substituted duplex DNA (ΔT(m) > 15 °C). Mg(2+) neither inhibited EtBr complexation nor had as strong of a stabilizing effect. DNA sequences that did not contain consecutive FdU were not stabilized by Zn(2+). A lipofectamine preparation of the Zn(2+)-DNA complex displayed enhanced cytotoxicity toward prostate cancer cells relative to the individual components prepared as lipofectamine complexes indicating the potential utility of Zn(2+)-DNA complexes for cancer treatment.
Modeling diffusive phenomena using non integer derivatives (2004)

In order to evaluate losses during energetical transfers, accurate battery models are needed in embedded power systems. The accuracy of those is all the more important as in hybrid vehicles, batteries are continuously charged and discharged. This paper deals with a dynamical model of NiMH battery, the originality of which lays on the use of non integer derivatives to model diffusion phenomena. With this method, we represent the battery by an equivalent electric scheme, whose components are identified by an experimental technique called “Electrochemical Impedance Spectroscopy (E.I.S.)". This identification process has been applied to a commercially available NiMH cell and its relevance checked by comparing digital simulations and laboratory experiments.
Electrochemical Deposition of Zinc-Based Composite Coatings Modified with Carbon Nanotubes from Alkaline Electrolyte (2020)

Composite electrochemical coatings (CECs) based on zinc, modified with carbon nanotubes (CNTs) from an alkaline electrolyte in a pulsed electrolysis mode have been obtained. The microstructure and tribological properties of these CECs are investigated. It was found that the introduction of the dispersed CNT phase into the alkaline galvanizing electrolyte reduces the sliding friction coefficient of the forming coatings by a factor of 1.30–1.45. The corrosion–electrochemical behavior of zinc–CNT CECs in 0.5 M solution of H2SO4 has been described.
External beam radiotherapy for retinoblastoma: II. Lens sparing technique. (1995)

A retrospective analysis is presented of the results of external beam radiotherapy for retinoblastoma utilising an accurate lens sparing technique. Local tumour control has been assessed in a consecutive series of 67 eyes in 53 children all of whom received external beam radiotherapy as the primary treatment of retinoblastoma. Follow up ranged from 12 to 82 months (median 35 months) with 76% of the children followed for more than 2 years. Tumour control rates have been analysed with respect to the Reese-Ellsworth classification. The role of adjuvant and salvage focal therapy is emphasised. Following lens sparing radiotherapy with prior adjuvant treatment of anterior tumours, where appropriate, the overall ocular cure rate was 72%. With salvage therapy of persistent, recurrent, or new tumours, 93% of eyes could be preserved in this series which includes mainly eyes classified in Reese-Ellsworth groups I-III. These results compare favourably with those of whole eye external beam radiotherapy for comparable tumours, and with those of lens and anterior segment sparing using other techniques. They were achieved without the ocular morbidity associated with whole eye external beam radiotherapy.
sd-type Exchange Interactions in Nonhomogeneous Ferromagnets (2004)

Motivated by a need to understand spin-momentum transport in CPP (current perpendicular to the plane) structures, a quantum field theoretical treatment of spin-spin interactions in ferromagnets is presented. The sd interaction of the conduction electrons and the magnetic medium is treated non-perturbatively from first principles in real space. The localized magnetic moments also interact with each other through a Heisenberg exchange potential. To take into account correlation effects, a second quantized formulation is used. The semi-classical limit is taken by using a coherent-state path-integral technique which also allows us to go beyond a linear-response approach. We derive a set of coupled equations of motion for the nonuniform magnetization, the spin current and the two-point correlation functions of the magnetization. The rate of change of the magnetization is shown to obey a generalized Landau-Lifshitz equation that takes into account interaction with the conduction electrons. Within the relaxation time approximation it is shown that the polarization of the conduction electrons obeys a diffusion equation. The diffusion tensor, which has off-diagonal terms due to the sd exchange interaction, is now explicitly dependent on the magnetization of the medium. We also show that the magnetization fluctuations satisfy a diffusion-type equation. The derived equations are used in two illustrative examples.
A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis (2020)

<b>Rationale:</b> MicroRNAs are known to influence the development of a variety of cancers. Previous studies revealed that miR-1291 has antiproliferative functions in cancer cells. Carnitine palmitoyltransferase 1C (CPT1C) has a vital role in mitochondrial energy metabolism and modulation of cancer cell proliferation. Since both miR-1291 and CPT1C regulate tumor cell metabolism and cancer progression, we hypothesized that they might be regulated synergistically. <b>Methods:</b> A series of cell phenotype indicators, such as BrdU, colony formation, cell cycle, ATP production, ROS accumulation and cell ability to resist metabolic stress, were performed to clarify the effects of miR-1291 and ERRα expression on tumor cell proliferation and metabolism. A xenograft tumor model was used to evaluate cell tumorigenesis. Meta-analysis and bioinformatic prediction were applied in the search for the bridge-link between miR-1291 and CPT1C. RT-qPCR, western-blot and IHC analysis were used for the detection of mRNA and protein expression. Luciferase assays and ChIP assays were conducted for in-depth mechanism studies. <b>Results:</b> The expression of miR-1291 inhibited growth and tumorigenesis as a result of modulation of metabolism. CPT1C expression was indirectly and negatively correlated with miR-1291 levels. <i>ESRRA</i> was identified as a prominent differentially expressed gene in both breast and pancreatic cancer samples, and estrogen-related receptor α (ERRα) was found to link miR-1291 and CPT1C. MiR-1291 targeted ERRα and CPT1C was identified as a newly described ERRα target gene. Moreover, ERRα was found to influence cancer cell metabolism and proliferation, consistent with the cellular changes caused by miR-1291. <b>Conclusion:</b> This study demonstrated the existence and mechanism of action of a novel miR-1291-ERRα-CPT1C cancer metabolism axis that may provide new insights and strategies for the development of miRNA-based therapies for malignant cancers.
Involvement of vimentin in the reverse transformation reaction. (1989)

An organized cytoskeleton is required for the cAMP-induced reverse transformation reaction in CHO-K1 cells. In the course of the reaction a considerable fraction of the genome changes its nuclease sensitivity. The current paper presents the following evidence that cAMP-induced phosphorylation of vimentin is an early step in this reaction complex. (i) Vimentin is only slightly phosphorylated in transformed CHO-K1 cells but is heavily phosphorylated in normal fibroblasts. (ii) cAMP addition almost triples the vimentin phosphorylation of CHO-K1 cells but does not change that of normal cells. (iii) Vimentin phosphorylation is one of the earliest phenomena to occur after addition of cAMP to CHO-K1 cells, preceding the cell-stretching reaction and other manifestations of reverse transformation. (iv) Indirect immunofluorescence experiments demonstrate that vimentin appears as a condensed mass in transformed CHO-K1 cells but cAMP addition restores the filamentous structure characteristic of the normal fibroblast. (v) Other transformed cells unresponsive to reverse transformation by cAMP failed to demonstrate increased phosphorylation of vimentin on treatment with cAMP. These results support the proposed scheme that phosphorylation of cytoskeletal elements initiates a large-scale genetic regulatory action in which a substantial change in the spectrum of genome exposure and sequestration occurs. A function for intermediate filaments in reverse transformation is implied.
EFFECT OF DAILY HERBAGE ALLOWANCE ON THE PERFORMANCE OF SPRING-CALVING DAIRY COWS (2003)

The aim of this study was to investigate the relationship between daily herbage allowance (DHA) and the performance of dairy cows. Forty-eight multi-parous spring-calving (mean date, 19 February) Friesian cows were divided into three equal groups and assigned to one of three levels of DHA (above a cutting height of 35 mm) of 16 (L), 20 (M) and 24 (H) kg dry matter per head from May to August, 1995. The daily allowances were equivalent to 14.5, 18.1 and 21.9 kg organic matter (OM) per head. The cows grazed to sward heights (mm) of 44, 55 and 65 (s.e. 0.6) and residual herbage masses (above 35 mm) of 276, 404 and 509 kg OM/ha (s.e. 14.2) for L, M and H DHA, respectively. Pastures were mechanically topped post-grazing. Cows consumed 13.5, 14.6 and 15.1 kg OM (s.e. 0.30) at L, M and H DHA, respectively. Mean daily milk production of the cows grazing at L, M and H DHA was 20.8, 223 and 23.0 kg (s.e. 0.31), respectively, and the corresponding milk protein concentrations were 32.4, 32.8 and 33.6 g/kg (s.e. 0.25). Daily milk yield could be predicted from pre-experimental yield and DHA according to the following model: y = A + 0.66 (s.e. 0.052) x pre-experimental milk yield + 0.304 (s.e. 0.0410) X DHA (r.s.d. 1.68; R 2 0.74), where A = 2.04, 0.62, -2.88 and -3.12 as the intercepts for May, June, July and August, respectively. The results indicate that good individual cow and herd production levels can be achieved from high quality herbage without concentrate supplement during the summer at a daily allowance of 24 kg herbage dry matter above 35 mm.
The formal oxidative addition of electron-rich transoid dienes to bromonaphthoquinones (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe formal oxidative addition of electron-rich transoid dienes to bromonaphthoquinonesJohn R. Grunwell, Anastas Karipides, Carl T. Wigal, Stephen W. Heinzman, John Parlow, Joan A. Surso, Laura Clayton, Fred J. Fleitz, Martin Daffner, and Jonathan E. StevensCite this: J. Org. Chem. 1991, 56, 1, 91–95Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/jo00001a020https://doi.org/10.1021/jo00001a020research-articleACS PublicationsRequest reuse permissionsArticle Views1684Altmetric-Citations84LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Terahertz absorption in non-polar, non-hydrogen-bonding liquids (2009)

We present results from our investigation into the liquid-lattice structures of n-pentane (C5H12) through n-hexadecane (C16H34). We observe alternating absorption values, at single frequencies, which are surprising and provide information about long-range correlations in liquids.
Decentralized control in packet switched satellite communication (1979)

The model introduced by Schoute [1] is analyzed using a minimum principle for decentralized stochastic control [2]. For certain values of the input message rates <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</tex> and number <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</tex> of transmitting stations, simple open-loop strategies are shown to be person-by-person optimal. The true optimal control is shown to be open loop for <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N = 2</tex> .
Plasmonic Electricity: Fluorophore-Induced Plasmonic Current (2019)

Fluorophore-induced plasmonic current is generated when an excited fluorophore in close proximity to a metal nanoparticle film nonradiatively transfers energy to the metal, resulting in an electrical current across the film. Although a growing literature reports the use of surface plasmons for fluorescence enhancement as well as plasmons for current generation, little has been published hitherto regarding the electrical current generation via the fluorophore excitation of plasmons. Our “plasmon to current” technique utilizes electron transport between closely spaced metal nanoparticles, generating a measurable electrical signal upon excitation of a proximal fluorophore. This induced electrical signal is found to be strongly dependent on the magnitude of the fluorophore extinction coefficient. In other words the electrical signal contains photophysical information pertaining to the fluorophore, potentially leading to the direct detection of fluorescence without the need for traditional detectors such as photomultiplier tubes and charge coupled devices. In addition, we demonstrate the dependence of this current on fluorophore concentration and excitation laser polarization. Fluorophore-induced plasmonic current holds potential as a novel molecular detection platform with simplified instrumentation, compatible with a variety of fluorescent probes.