gebhart/patrepeval huggingface dataset:
Supplementary Figure 6 from microRNA-Associated Progression Pathways and Potential Therapeutic Targets Identified by Integrated mRNA and microRNA Expression Profiling in Breast Cancer (2023)

&lt;p&gt;PDF file - 141K, Immunohistochemistry (IHC) of miR-144 predicted target gene NFE2L2.&lt;/p&gt;
Dedicated E-reading Devices: the State of the Art and the Challenges (2008)

Dedicated electronic text reading (e-reading) devices hold the potential to drastically improve e-reading&#13;\nexperiences. Nevertheless, up to now they remain in a niche market. This paper surveys existing&#13;\ndedicated e-reading devices and related research to examine the state of the art and the challenges.&#13;\nFirstly, it briefly recounts the evolution of e-reading devices; secondly, it examines the development&#13;\nand issues regarding several critical aspects of this type of device, including form factor, display,&#13;\ninteraction methods, connectivity, and e-text distribution methods; finally, it analyzes the reasons why&#13;\nthese devices have not become mainstream, and speculates on their future.
Polyetherimides. I. Preparation of dianhydrides containing aromatic ether groups (1985)

Abstract A general synthetic method and characterization of bis(ether anhydride)s, the ether containing aromatic dianhydrides of the following structure, are presented. magnified image The method involves aromatic nitro‐displacement of N ‐substituted 3‐ or 4‐nitrophthalimide with bisphenoxides to form N ‐substituted arylene‐bis(phthalimido)ethers or bis(ether imide)s. Sixteen structurally different bis(ether imide)s have been prepared and subsequently converted to the corresponding bis(ether anhydride)s. Bis(ether anhydride)s are stable crystalline compounds of a moderate reactivity. Unlike highly reactive dianydrides such as pyromellitic and benzophenonetetracarboxylic dianhydrides bis(ether anhydride)s are semipermanently stable against hydrolysis in the presence of atmospheric moisture.
Multistage semi-blind spatio-temporal processing for short burst multiuser SDMA systems (2002)

In short burst multiuser spatial division multiple access (SDMA) systems, the accessible volume of data for adjusting the coefficients of spatio-temporal filters may not be large enough to allow global convergence of existing semi-blind algorithms. A multistage algorithm which significantly increases the probability of global convergence without enlarging the training sequence is presented. It is based on the observation that in multiuser environments, it may be efficient to achieve global convergence for "at least one user" rather than global convergence for "all users". Then, information from one stage call be used in the next stage to enhance the estimation of the remaining users.
Impact of Water on Asphalt Aging (2012)

Atmospheric pressure aging experiments were conducted to determine whether the presence of moisture during aging at a pavement service temperature of 60°C had any significant influence on the aging kinetics of thin (100-micron) asphalt binders. The five binders studied were aged in both dry and humid atmospheres. Infrared spectra of the dry- and moist-aged binders were compared. Master curves (dry aged and moist aged) generated from dynamic shear rheometry tests were also compared. The results showed that moisture had no significant effect on the oxidation rate at atmospheric pressure. A first-order and zero-order aging kinetic model was applied to fit all the chemical results. The Arrhenius equation was employed to calculate the activation energy for carbonyl and sulfoxide formations on all of the asphalts. The observed activation energies indicated that asphalt AAD-1 was more sensitive to the aging temperatures than the other four tested asphalts on the rapid carbonyl formation. However, after the initial spurt, the reaction rate of asphalt AAD-1 became more stable than in the other four asphalts. Sulfoxide formation was also evaluated. Rheological property changes with aging correlated reasonably well with carbonyl and sulfoxide concentration changes of asphalt binders as a consequence of atmospheric pressure aging. The master curves of complex modulus and phase angle for dry-aged and moist-aged asphalt binders fall right on top of each other and indicate that aging in the presence of water (99% of relative humidity) at the ambient pressure at pavement service temperature does not influence the rheological properties of asphalt binders.
Effects of 3‐Hydroxy‐3‐methylglutaric Acid on Plasma and Low‐Density Lipoprotein Cholesterol Levels in Familial Hypercholesterolemia (1979)

Different doses of 3-hydroxy-3-methyl-glutaric acid (HMG) on plasma lipids were studied in a double-blind trial in 36 patients with familial hypercholesterolemia (type IIa or hyper-beta-lipoproteinemia). The patients were randomly assigned to five groups, and each group received one of the following treatments: placebo, or HMG 750 mg, 1500 mg, 2250 mg, or 3000 mg per day. As compared to placebo, the mean plasma cholesterol levels during the eight-week treatment period were 11 and 13 per cent lower in the 2250-mg and 3000-mg HMG-treated groups (P less than 0.034 and less than 0.021, respectively). At the same dosage levels LDL cholesterol was decreased by 8 per cent. HMG had no significant effect on plasma triglycerides as compared to placebo. Discontinuation of the medication did not result in a rebound of plasma cholesterol. There were no clinical or biologic adverse effects due to the administration of HMG, and all patients maintained excellent compliance to the medication. Because of its lack of toxicity, HMG may be useful as an adjunct to diet in the treatment of familial hypercholesterolemia.
Micellization and Mobility of Amphiphilic Poly(2-oxazoline) Based Block Copolymers Characterized by1H NMR Spectroscopy (2015)

Three amphiphilic diblock poly(2-oxazoline) copolymers composed of the hydrophilic poly(2-methyl-2-oxazoline) and hydrophobic poly(2-alkyl-2-oxazoline) with alkyl = pentyl (P1), heptyl (P2), and nonyl side chain (P3) lengths of the hydrophobic block were synthesized by ring-opening cationic polymerization. These polymers form micelles in water above their critical micelle concentration. The temperature-dependent stability of the micellar aggregates was analyzed by DLS and turbidity measurements as well as pyrene solubilization between 20 and 80 °C in water. Moreover, the chemical composition of the block copolymers was determined by 1H NMR spectroscopy. In particular, it was possible to quantify the degree of aggregations of the individual groups of both blocks by including the chemical composition into the derived equations. It could be shown by varying the temperature that both the chemical composition and the degree of micellization depend on the number of bonds of the considered structural groups of the side chain with respect to the backbone of the hydrophobic block as well as the length of the side chain. In addition, temperature-dependent T1 and T2 measurements were performed to determine the dynamics of the structural groups of the hydrophilic and hydrophobic blocks. Correlation times and activation energies were determined of the individual structural groups confirming the different mobilities.
Development of Fingertip Type Non-grounding Force Feedback Display (2007)

Force feedback displays to represent virtual objects with non-grounding and no reaction base on the human body are convenient and effective for mobile uses. Especially, these sensations are expected to be applied to ubiquitous/mobile/wearable interfaces for technical training, rehabilitation and telemanipulation in the variety fields of medical care, healthcare, and welfare. In this paper, fingertip type non-grounding force feedback display has been developed to represent the feeling of presence and shape of virtual objects continuously by downsizing to be mounted to fingertip and position feedback controlling. This display represents haptic sensation of vibration, torque, and force feedback in any arbitrary direction by controlling rotor acceleration and phase difference of eccentrically weighted rotators
Properties of Very Luminous Galaxies (1998)

Recent analysis of the SSRS2 data based on cell–counts and two–point correlation function has shown that very luminous galaxies are much more strongly clustered than fainter galaxies. In fact, the amplitude of the correlation function of very luminous galaxies (L&amp;gt; L ∗ ) asymptotically approaches that of R ≥ 0 clusters. In this paper we investigate the properties of the most luminous galaxies, with blue absolute magnitude MB ≤ −21. We find that: 1) the population mix is comparable to that in other ranges of absolute magnitudes; 2) only a small fraction are located in bona fide clusters; 3) the bright galaxy–cluster cross–correlation function is significantly higher on large scales than that measured for fainter galaxies; 4) the correlation length of galaxies brighter than MB ∼ −20.0, expressed as a function of the mean interparticle distance, appears to follow the universal dimensionless correlation function found for clusters and radio galaxies; 5) a large fraction of the bright galaxies are in interacting
Tumor Antigens Recognized by T Lymphocytes (1994)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Entanglement Networks of 1,2-Polybutadiene Cross-Linked in States of Strain. 8. Trapping of Entanglements in Relaxed and Unrelaxed Configurations (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEntanglement Networks of 1,2-Polybutadiene Cross-Linked in States of Strain. 8. Trapping of Entanglements in Relaxed and Unrelaxed ConfigurationsHsin-Chia Kan and John D. FerryCite this: Macromolecules 1979, 12, 3, 494–498Publication Date (Print):May 1, 1979Publication History Published online1 May 2002Published inissue 1 May 1979https://pubs.acs.org/doi/10.1021/ma60069a030https://doi.org/10.1021/ma60069a030research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reply (2014)

Patients with the deadly cancer, cholangiocarcinoma (CCA), are in dire need of improved diagnostics.1 Our recent endeavors in this field yielded a microRNA marker panel developed based on extracellular vesicles (EVs) present in human bile.2 Our declared goal was to identify a CCA marker panel that is reproducible and accurate. With reproducibility in mind, we purposely sought a bile processing protocol that can easily be performed in a clinical laboratory. In addition, while ultimately pursuing accuracy, we did not seek to be all-inclusive regarding sources of microRNA in human bile. Through direct experimentation, we found that utilization of whole bile for microRNA extraction, as previously described,3 yields a higher quantity of microRNA per volume unit of bile. However, in our hands, when whole bile was used, microRNA species extracted demonstrated a much higher variation as a function of the bile processing protocol, storage at room temperature, and freeze-thaw cycles. Therefore, we deliberately moved away from whole bile and explored biliary EVs as a sole source of microRNA. We found that, although the quantity of microRNA extracted per volume unit of bile was less, the stability of microRNA expression was greatly improved.2 Specimen collection in clinics and hospitals is subject to variability; moreover, the more stringent the requirements for strict collection and storage protocols, the higher the cost and the likelihood of poor-quality specimens. As correctly noted in the Letter to the Editor by our colleagues (Roest et al., this issue), we did not use the full spectrum of microRNAs present in human bile, but restricted our analyses to EV-sourced microRNAs. While further studies may demonstrate that the use of soluble microRNA fraction will yield further improved accuracy, such experiments were not the aim of the current study. We sought accuracy, simplicity, and reproducibility. We deem this tradeoff acceptable, as our marker panel displays high reproducibility and minimal requirements with regard to sample collection, storage, and processing, while providing an additional diagnostic tool to increase diagnostic accuracy in CCA patients. Ling Li, M.D., Ph.D.Florin M. Selaru, M.D. Johns Hopkins University Johns Hopkins Hospital Baltimore, MD
Solid-state cultivation of Talaromyces emersonii on beet pulp (1985)

Conference Article| April 01 1985 Solid-state cultivation of Talaromyces emersonii on beet pulp P. J. CONSIDINE; P. J. CONSIDINE *I.I.R.S. Biochemicals Unit, University College, Galway, Ireland Search for other works by this author on: This Site PubMed Google Scholar A. O'RORKE; A. O'RORKE *I.I.R.S. Biochemicals Unit, University College, Galway, Ireland Search for other works by this author on: This Site PubMed Google Scholar A. P. MOLONEY; A. P. MOLONEY †Departments of Biochemistry, University College, Galway, Ireland Search for other works by this author on: This Site PubMed Google Scholar P. M. T. CURRAN; P. M. T. CURRAN ‡Departments of Botany, University College, Galway, Ireland Search for other works by this author on: This Site PubMed Google Scholar F. R. COMERFORD; F. R. COMERFORD §Departments of Experimental Medicine, University College, Galway, Ireland Search for other works by this author on: This Site PubMed Google Scholar M. P. COUGHLAN M. P. COUGHLAN †Departments of Biochemistry, University College, Galway, Ireland Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1985) 13 (2): 456. https://doi.org/10.1042/bst0130456 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation P. J. CONSIDINE, A. O'RORKE, A. P. MOLONEY, P. M. T. CURRAN, F. R. COMERFORD, M. P. COUGHLAN; Solid-state cultivation of Talaromyces emersonii on beet pulp. Biochem Soc Trans 1 April 1985; 13 (2): 456. doi: https://doi.org/10.1042/bst0130456 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1985 Biochemical Society1985 Article PDF first page preview Close Modal You do not currently have access to this content.
Expression and regulation of the TGF-β activating integrin αvβ8 on human mononuclear phagocytes (MUC8P.809) (2014)

Abstract Induction of Foxp3+ Tregs is important in suppressing immune responses to commensal bacteria and innocuous antigen in the gut. Previous work from our lab has shown that, in mice, expression of the integrin αvβ8 on intestinal dendritic cells (DC) is important for activation of the cytokine TGF-β and subsequent Treg induction, with lack of this pathway resulting in severe inflammatory bowel disease (IBD). Additionally, integrin αvβ8 is highly expressed on murine intestinal CD103+ DC compared to other intestinal mononuclear phagocytes, and is required for enhanced Treg induction by CD103+ intestinal DC and maintenance of immune homeostasis. However, pathways that control integrin αvβ8 expression are poorly understood and the role of integrin αvβ8 in human immunology is currently unknown. Here, we show that integrin αvβ8 is expressed preferentially on CD64+ macrophages and to a lesser extent on DC populations, in contrast to what is found in mouse models. Analysis of monocyte-derived macrophage populations indicated that M2-like macrophage populations preferentially expressed integrin αvβ8. Interestingly, treatment of monocyte-derived DCs with the LPS causes up-regulation of integrin αvβ8 expression, indicating that bacterial ligands may be an important cue in triggering integrin αvβ8 expression on DC. Thus, enhanced expression of integrin αvβ8 on certain human mononuclear phagocyte subsets may implicate these populations in the control of TGF-β dependent immune responses.
A review of the applications of imiquimod: a novel immune response modifier (2001)

Imiquimod (1-(2-methylpropyl)-1 H-imidazo[4,5-c]quinolin-4-amine) and its analogues are a class of non-nucleoside imidazoquinolinamines (hetero-cyclic amine) that activate the immune system through localised induction of cytokines, such as IFN-alpha, -beta, and a number of endogenous interleukins. The exact mechanism of its actions are still unexplored, although when tested in a number of cell culture systems, imiquimod demonstrated no inherent antiviral or antiproliferative activity in vitro, whereas, due to its reported ability to produce onsite stimulation and secretion of cytokines in various in vivo studies, such types of immune response modifiers have been shown to cause diverse biological functions, involving immunoregulatory, antiviral, antiproliferative and antitumour activities. These data support a rational justification to consider imiquimod as an innovative topical agent to treat various cutaneous diseases. Since its synthesis in 1980,several studies using animal models and human subjects have been reported substantiating its usefulness as a treatment option for various skin disorders such as genital warts, genital herpes, molluscum contagiosum, basal cell carcinoma and psoriasis. Imiquimod is insoluble in water but in most of the clinical studies its incorporation from 1 - 5% by weight in an oil-into-water cream emulsion has been reported as being well-tolerated with mild-to-moderate drug-related side effects, such as itching, burning sensation, pain, erythema, erosion and oedema. As a potent immune response modifier and an agent stimulating cell-mediated immune responses, imiquimod appears to be a promising drug to treat many skin disorders, infections and neoplasms.
Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter (2019)

The human ABCG2 multidrug transporter plays a crucial role in the absorption and excretion of xeno- and endobiotics; thus the relatively frequent polymorphic and mutant ABCG2 variants in the population may significantly alter disease conditions and pharmacological effects. Low-level or non-functional ABCG2 expression may increase individual drug toxicity, reduce cancer drug resistance, and result in hyperuricemia and gout. In the present work we have studied the cellular expression, trafficking, and function of nine naturally occurring polymorphic and mutant variants of ABCG2. A comprehensive analysis of the membrane localization, transport, and ATPase activity, as well as retention and degradation in intracellular compartments was performed. Among the examined variants, R147W and R383C showed expression and/or protein folding defects, indicating that they could indeed contribute to ABCG2 functional deficiency. These studies and the applied methods should significantly promote the exploration of the medical effects of these personal variants, promote potential therapies, and help to elucidate the specific role of the affected regions in the folding and function of the ABCG2 protein.
Intrauterine contraception: incidence and factors associated with uterine perforation--a population-based study (2012)

As the study setting revealed only symptomatic patients or those attending regular follow-up, the true incidence might be somewhat higher. As there is no specific diagnostic code for uterine perforation or treatment, it is unlikely that all cases of uterine perforation can be identified in a retrospective study.
Drastic influence of the half-bowtie resonances on the focusing and collimating capabilities of 2-D extended hemielliptical and hemispherical dielectric lenses (2010)

The interplay between the optical focusing and wavelength-scale resonant features of extended hemielliptical (EHE) and extended hemispherical (EHS) lenses is studied in the two-dimensional (2-D) formulation using highly accurate in-house software based on the Muller boundary integral equations. The influence of the half-bowtie (HBT) resonances on the focusing and collimating capabilities of medium-size EHE and EHS lenses made of silicon is characterized as a function of lens parameters and excitation conditions. As a result, factors determining the parasitic impacts of the HBT resonances on the performance of integrated lens antennas are highlighted.
Design and Construction of an EMG Multichannel Acquisition System Prototype (2012)

This thesis presents the design and construction of an Electromyography (EMG) high−density acquisition system prototype at the Deutschen Zentrums fur Luft und Raumfahrt (DLR) Bionics group in Munich− Germany. It does not intend to come up with new principles of EMG recording, but its scope is to search, compare, simulate, construct and validate nowadays available solutions that fulfill the imposed requirements.
The design consists in ten functional blocks that cover all the system aspects from the power supply to the measuring electrodes. In order to construct the circuit prototype, some classical solutions were implemented and some novelty configurations were explored, for instance: a novelty DC rejection filter without grounded resistors, to prevent degradation of the front−end amplifier Common Mode rejection (CMR) and the driven shields that solved the problem of amplifying the EMG signal at a considerable distance from the source.
This document covers all the way in between the muscles and the computer, that EMG signals go through: electrodes, esd protection, shield cables, DC rejection, amplification, Driven Right Leg feedback, filtering, isolation and digitization.
Beyond the Instructions for Use: Pushing the Limits of Infrarenal Device Application for Abdominal Aortic Aneurysms (2006)

Endograft devices are used to treat 40% to 80% of patients with abdominal aortic aneurysms. A much smaller percentage of patients have ideal anatomy, for which the devices were designed. Vascular surgeons and interventionalists have become increasingly creative in endograft placement to exclude aneurysms, despite the presence of complex aortoiliac anatomy. Arterial diameter and angulation are the most common barriers to successful endograft placement. In response to this need, graft manufacturers are increasing graft size choices, improving device flexibility, and providing improved arterial wall fixation. Despite newer devices, providers still must push the limits of defined anatomy based on the manufacturers recommended instructions to repair most infrarenal aneurysms.
On Stretching Gaussian Noises with the Phase Vocoder (2012)

International audience