gebhart/patrepeval huggingface dataset:
Correction: Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers (2018)

[This corrects the article DOI: 10.18632/oncotarget.25308.].
Relationship between Segmental Dynamics Measured by Quasi-Elastic Neutron Scattering and Conductivity in Polymer Electrolytes (2018)

Quasi-elastic neutron scattering experiments on mixtures of poly(ethylene oxide) and lithium bis(trifluoromethane)sulfonimide salt, a standard polymer electrolyte, led to the quantification of the effect of salt on segmental dynamics in the 1-10 Å length scale. The monomeric friction coefficient characterizing segmental dynamics on these length scales increases exponentially with salt concentration. More importantly, we find that this change in monomeric friction alone is responsible for all of the observed nonlinearity in the dependence of ionic conductivity on salt concentration. Our analysis leads to a surprisingly simple relationship between macroscopic ion transport in polymers and dynamics at monomeric length scales.
Selection of flow-distributed oscillation and Turing patterns by boundary forcing in a linearly growing, oscillating medium (2009)

We studied the response of a linearly growing domain of the oscillatory chemical chlorine dioxide-iodide-malonic acid (CDIMA) medium to periodic forcing at its growth boundary. The medium is Hopf-, as well as Turing-unstable and the system is convectively unstable. The results confirm numerical predictions that two distinct modes of pattern can be excited by controlling the driving frequency at the boundary, a flow-distributed-oscillation (FDO) mode of traveling waves at low values of the forcing frequency f , and a mode of stationary Turing patterns at high values of f . The wavelengths and phase velocities of the experimental patterns were compared quantitatively with results from dynamical simulations and with predictions from linear dispersion relations. The results for the FDO waves agreed well with these predictions, and obeyed the kinematic relations expected for phase waves with frequencies selected by the boundary driving frequency. Turing patterns were also generated within the predicted range of forcing frequencies, but these developed into two-dimensional structures which are not fully accounted for by the one-dimensional numerical and analytical models. The Turing patterns excited by boundary forcing persist when the forcing is removed, demonstrating the bistability of the unforced, constant size medium. Dynamical simulations at perturbation frequencies other than those of the experiments showed that in certain ranges of forcing frequency, FDO waves become unstable, breaking up into harmonic waves of different frequency and wavelength and phase velocity.
Electrochemistry of Solvent-Free Liquid Quinones (2020)

Redox flow batteries are a promising candidate for grid energy storage due favorable scaling and cyclability but are limited by low energy density due to poor solubility of active species in both aqueous and organic solvent. To increase the energy density we investigate the use of a solvent free liquid quinone electrolyte, resulting in high active species concentration (&gt;10M). Well studied in aqueous and organic solvents, the electroreduction of quinones has been shown to strongly depend on the solvent [1] and supporting electrolyte [2]. The absence of inert solvent poses additional challenges due to mass transport and reaction effects in highly concentrated solutions [3]. Here we characterize the physical and electrochemical properties of 2,3,5-trimethyl-1,4-benzoquinone, ranging in concentration from a dilute solution in inert organic solvent to a highly concentrated solvent-free liquid quinone. Using ultramicroelectrode techniques, diffusion and redox kinetics are determined for solvated and solvent free liquid quinones to investigate the feasibility of this material for use as a solvent free redox flow battery electrolyte. References: [1] M. Quan, D. Sanchez, M. F. Wasylkiw, D. K. Smith, J. Am. Chem. Soc. 2007, 129, 42, 12847-12856 [2] D. Pletcher, H. Thompson, J. Chem. Soc. , Faraday Trans. 1998, 94, 3445-3450 [3] R. B. Morris, K. F. Fischer, H. S. White, J. Phys Chem. 1988, 92, 5306-5313
Phase I Dose-Escalation and -Expansion Study of Telisotuzumab (ABT-700), an Anti–c-Met Antibody, in Patients with Advanced Solid Tumors (2020)

This first-in-human phase I study evaluated the pharmacokinetics, safety, and preliminary efficacy of telisotuzumab, formerly called ABT-700, an antagonistic antibody directed against c-Met. For dose escalation (3+3 design), 3 to 6 patients with advanced solid tumors were enrolled into four dose cohorts (5-25 mg/kg). In the dose-expansion phase, a subset of patients was prospectively selected for <i>MET</i> amplification (FISH screening). Patients received telisotuzumab intravenously on day 1 every 21 days. For dose expansion, 15 mg/kg was chosen as the dose on the basis of safety, pharmacokinetics, and other data from the escalation cohorts. Forty-five patients were enrolled and received at least one dose of telisotuzumab (dose escalation, <i>n</i> = 15; dose expansion, <i>n</i> = 30). Telisotuzumab showed a linear pharmacokinetics profile; peak plasma concentration was proportional to dose level. There were no acute infusion reactions and no dose-limiting toxicities were observed. The most common treatment-related adverse events included hypoalbuminemia (<i>n</i> = 9, 20.0%) and fatigue (<i>n</i> = 5, 11.1%). By Response Evaluation Criteria In Solid Tumors (RECIST), 4 of 10 (40.0%) patients with <i>MET</i>-amplified tumors had confirmed partial response in target lesions (one ovarian, two gastric, and one esophageal), two (20.0%) had stable disease, three (30.0%) had progressive disease; one patient was unable to be evaluated. Among patients with nonamplified tumors (<i>n</i> = 35), no objective responses were observed; however, 11 patients had stable disease per RECIST criteria. In conclusion, telisotuzumab has an acceptable safety profile with clinical activity observed in patients with <i>MET</i>-amplified advanced solid tumors.
Computer simulation of the spinodal decomposition for a polydisperse polymer mixture (1993)

A computer simulation of the dynamical evolution of the domain structure via spinodal decomposition was performed for a binary polymer blend in which one component has a bimodal molecular-weight distribution. The results indicated that the dynamical scaling law is valid for this polydisperse system.
Analysis of an intracavity-doubled diode-pumped Q-switched Nd:YAG laser producing more than 100 W of power at 0532 µm (1998)

A diode-pumped Nd:YAG laser was frequency doubled to 0.532 microm with an intracavity KTiOPO(4) crystal in a V-cavity arrangement, achieving an output power of 140 W. Acousto-optic Q switching was employed at repetition rates of 10-30 kHz, and the beam quality was assessed at M(2) approximately 50. It was deduced on the basis of our model that the strength of the nonlinear frequency conversion is the main parameter determining the pulse width.
Cardiovascular risk associated with testosterone-boosting medications: a systematic review and meta-analysis (2014)

The present systematic review and meta-analysis does not support a causal role between TS and adverse CV events. Our results are in agreement with a large body of literature from the last 20 years supporting TS of hypogonadal men as a valuable strategy in improving a patient's metabolic profile, reducing body fat and increasing lean muscle mass, which would ultimately reduce the risk of heart disease.
Quinone and iron porphyrin mediated reduction of nitroaromatic compounds in homogeneous aqueous solution (1990)

The kinetics of reductive transformations of a series of monosubstituted nitrobenzenes and nitrophenols have been investigated in aqueous solution containing reduced sulfur species and small concentrations of either a naphthoquinone or an iron porphyrin. Boith the two naphthoquinones and the iron porphyrin used in this study mediated the reduction of the nitro group. In all three cases, the rate of reduction of the nitrobenzenes and of the nitrophenols was strongly pH dependent. Dissociated nitrophenols were reduced ~ 3-4 times more slowly as compared to the nondissociated species. For the substituted nitrobenzenes, the effect of substitution on the reaction rate could be described by a linear free energy relationship (LFER) of the general form log &lt;I&gt;k&lt;/I&gt; = &lt;I&gt;aE&lt;/I&gt;&lt;sub&gt;h&lt;/sub&gt;&lt;sup&gt;1'&lt;/sup&gt; + &lt;I&gt;b&lt;/I&gt;, where &lt;I&gt;k&lt;/I&gt; is the second-order rate constant for reaction with the hydroquinone monophenolate or the iron porphyrin, respectively, and &lt;I&gt;E&lt;/I&gt;&lt;sub&gt;h&lt;/sub&gt;&lt;sup&gt;1'&lt;/sup&gt; is the one-electron reduction potential of the nitroaromatic compound. Competition between different nitrobenzenes was observed in the case of the iron porphyrin, while no effects were found for the reaction with the hydroquinones. The results of this study form an important base for the evaluation and interpretation of reductive transformation processes of nitroaromatic compounds in the environment.
Support for Nomadism in a Global Environment (1997)

. The goal of nomadic computing transcends simply making one&amp;apos;s environment portable; mobile users require the ability to communicate with local servers despite location and to obtain local services despite statically defined service interfaces. To this end, we expect the portable computer or PDA to perform as a &amp;quot;universal interactor&amp;quot; [Theimer93]. The current paradigm for distributed computing, RPC, inhibits such free-form interaction. RPC requires static knowledge of the service and its interface; a programmer must know the interface and explicitly write code to use it. It is impossible, using present RPC implementations such as DCE or Sun RPC, to discover and use new services unless they conform exactly to the interfaces expected by the client. We propose a new standard to define a fundamental level of support for nomadism---that of service discovery. It is the ability for a client to discover services based on descriptive names, bind dynamically to the servers that offer them, and co...
Isolation and partial characterization of collagen from outer skin of Sepia pharaonis (Ehrenberg, 1831) from Puducherry coast (2017)

Type I collagen from outer skin of <i>Sepia pharaonis</i> was extracted and partially characterized. Yield of Acid Soluble Collagen (ASC) and Pepsin Soluble Collagen (PSC) were calculated as 1.66% and 3.93% and the total protein content of ASC and PSC were found as 18.4% and 48.6%. FT-IR spectrum of ASC and PSC recorded 12 and 14 peaks, respectively. <sup>1</sup>H NMR spectrum of ASC showed singlets at 1.23 ppm, 3.1 ppm, 3.55 ppm and 3.7 ppm and PSC at 1.23 ppm and 2.08 ppm. The molecular weight for ASC was calculated as 102 kDa and for PSC as 110, 108 and 102 kDa through SDS-PAGE. Differential Scanning Calorimetry (DSC) results supported that PSC withstand high thermal stability (82.85 °C) than ASC (73.13 °C). Higher denaturation temperature with high molecular weight well support the property of type I collagen from skin of <i>S. pharaonis</i> and it could be used as another potent source for the extraction of collagen.
Recognition of natural ice types on in-service glass insulators based on texture feature descriptor (2017)

For in-service transmission lines, insulator icing condition depends on analysis of images collected by cameras installed on towers, and ice type analysis is mostly completed by human beings, which is infeasible to monitor a large area. Although image processing is successfully applied to segmentation of insulators from aerial images, there are few literatures on automatically determining ice types on insulators via image processing. In this paper, a recognition method of ice types on in-service glass insulators is established based on a texture feature description operator. Uniform Local Binary Patterns (ULBP) and Improved Uniform Local Binary Patterns (IULBP) were adopted for texture feature extraction of typical images of six ice types including glaze ice, heavy rime, medium rime, light rime, partial rime and snow. The six ice types are concluded based on icing insulator images and corresponding meteorological data from China Southern Power Grid Transmission Line (Icing) Online Monitoring System. Ice types are recognized by correlation coefficient calculation of texture histograms. The experiment results show that IULBP obtains better results for recognition of the six ice types as each ice type has distinguished texture features.
Wrong Path Events: Exploiting Unusual and Illegal Program Behavior for Early Misprediction Detection and Recovery (2005)

Control and data speculation are widely used to improve processor performance. Correct speculation can reduce execution time, but incorrect speculation can lead to increased execution time and greater energy consumption. This paper proposes a mechanism to leverage unexpected program behavior, called wrong-path events, that occur during periods of incorrect speculation. A wrong-path event is an instance of illegal or unusual program behavior that is more likely to occur on the wrong path than on the correct path, such as a NULL pointer dereference. When a wrong-path event occurs, the processor can predict that it is on the wrong path and speculatively initiate misprediction recovery. The purpose of the proposed mechanism is to improve the effectiveness of speculative execution in a processor by helping to insure that the processor remain "on the correct path" throughout periods of speculative execution. We describe a set of wrong-path events which can be used as strong indicators of misprediction. We find that on average 5% of the mispredicted branches in the SPEC2000 integer benchmarks produce a wrong-path event an average of 51 cycles before the branch is executed. We show that once a wrong-path event occurs, it is possible to accurately predict which unresolved branch in the processor is mispredicted using a simple, novel prediction mechanism. We discuss the advantages and shortcomings of wrong-path events and propose new areas for future research.
The HGF/SF Mouse Model of UV-Induced Melanoma as an In Vivo Sensor for Metastasis-Regulating Gene (2017)

Cutaneous malignant melanoma is an aggressive and potentially lethal form of skin cancer, particularly in its advanced and therapy-resistant stages, and the need for novel therapeutics and prognostic tools is acute. Incidence of melanoma has steadily increased over the past few decades, with exposure to the genome-damaging effects of ultraviolet radiation (UVR) well-recognized as a primary cause. A number of genetically-engineered mouse models (GEMMs) have been created that exhibit high incidence of spontaneous and induced forms of melanoma, and a select subset recapitulates its progression to aggressive and metastatic forms. These GEMMs hold considerable promise for providing insights into advanced stages of melanoma, such as potential therapeutic targets and prognostic markers, and as in vivo systems for testing of novel therapies. In this review, we summarize how the HGF/SF transgenic mouse has been used to reveal metastasis-regulating activity of four different genes (<i>CDK4</i><sup>R24C</sup>, <i>survivin</i> and <i>NME1/NME2</i>) in the context of UV-induced melanoma. We also discuss how these models can potentially yield new strategies for clinical management of melanoma in its most aggressive forms.
Distribution of Collagen Types I, III, and V in Pregnant Mouse Endometrium (2007)

Decidualization in mice comprises a deep remodeling of extracellular matrix (ECM) components of the endometrium. In a previous biochemical study we showed that collagen types I and III are present in both pregnant and nonpregnant mouse endometrium, whereas collagen type V is expressed exclusively after the onset of decidualization. The distribution of collagen types in the pregnant mouse endometrium and possible changes of these molecular types in the different regions of the decidua is, however, not known. Using immunofluorescence and confocal microscopy we showed the presence of collagen types I, III, and V in the endometrial stroma of implantation and interimplantation sites from days 5 to 8 of pregnancy in the mouse. Collagen type III was chiefly expressed in the implantation sites and was the only collagen type to be present in the materno-fetal interface on the day of the embryo implantation. However, collagen type I was the predominant collagen in the interimplantation sites. Collagen type V was weakly expressed in the nondecidualized stroma during all periods but was expressed in larger amounts in the decidualized areas on day 7 of pregnancy, simultaneously with the accumulation of thick collagen fibrils in the same region. The highest immunofluorescence labeling for the three types of collagen was observed on day 7 when the antimesometrial decidual tissue achieved its greatest development. These data support previous studies that showed an intense ECM remodeling of the mouse endometrial stroma during the beginning of pregnancy. This outstanding remodeling may be important to stabilize placental anchorage.
Effects of Genital Ulcer Disease and Herpes Simplex Virus Type 2 on the Efficacy of Male Circumcision for HIV Prevention: Analyses from the Rakai Trials (2009)

Circumcision reduced GUD irrespective of HSV-2 status, but this reduction played only a modest role in the protective effect of circumcision on HIV acquisition.
Multi-Antenna Downlink Spatial Division Multiplexing with Opportunistic Feedback (2009)

In this paper, a new opportunistic feedback and user selection protocol is proposed for the multiple antenna downlink. The proposed scheme uses the structure of zero-forcing dirty paper coding (DPC) at the transmitter and selects users using a contention-based feedback channel. The user selection procedure is divided into stages and within each stage, a user is selected for one spatial channel (defined by the zero-forcing dirty paper coding strategy). The user feedback is controlled by a feedback probability and a feedback threshold. This method of feedback significantly reduces the resources used for feedback compared to dedicating feedback resources for each user. We optimize an approximation to the sum rate expression with respect to these parameters and illustrate the sum rate performance by simulations. The simulation shows that we can achieve good sum rate performance despite the reduction in feedback resources.
Internal Q-switching and self-optical parametric oscillation in a two-dimensional periodically poled Nd:MgO:LiNbO_3 laser (2012)

We report on an internally Q-switched self-optical parametric oscillator (SOPO) based on a monolithic two-dimensional (2D) periodically poled Nd:MgO:LiNbO(3) (Nd:MgO:PPLN) integrating three device functionalities of a laser gain medium, an electro-optic Bragg Q-switch, and an optical parametric gain medium (OPGM). The quasi-phase-matching conditions required by the Bragg Q-switch and OPGM are both satisfied in the 2D nonlinear photonic crystal (NPC) structure formed in the Nd:MgO:PPLN. A 1525 nm signal with a pulse energy of ∼3.3 μJ (>350 W peak power) was obtained from the SOPO at 8.5 W diode pump power. An off-angle signal at 1612 nm, amplified by a unique gain-enhancement effect in this 2D NPC, was also observed. Tuning of the SOPO in the eye-safe region was demonstrated.
A Simple Two-Step Template Approach for Preparing Carbon-Doped Mesoporous TiO2 Hollow Microspheres (2009)

Carbon-doped TiO2 hollow microspheres with mesoporous structure were prepared by a simple two-step template method. The characterizations for the physicochemical properties of prepared samples under different calcination temperature were carried out by X-ray diffraction analysis, Brunauer−Emmett−Teller measurements, transmission electron microscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, and UV−vis diffuse reflectance spectra. The carbon doping of TiO2 hollow spheres was easily achieved during the procedure for removal of carbon cores. With the doping of carbon, the absorption wavelength edge was expanded to the visible light region and the additional diffusive electronic states were observed on the valence band spectra of samples. C-doped TiO2 hollow spheres with rapid combustion at 500 °C exhibited the superior visible light photocatalytic activity for the degradation of toluene, 4.6 times greater than that of Degussa P25, due to its good crystallization, mesoporous structure composed by hollow sphere structure, and strong absorption in the visible light region. The procedure of carbon doping was discussed and the generating mechanism was proposed.
Effects of Counterions on Molecular Transport Across Liposome Bilayer:  Probed by Second Harmonic Generation (2001)

The transport rate of an organic cation, malachite green (MG), across a unilamellar bilayer (∼105 nm) of the dioleoylphosphatidylglycerol (DOPG) liposome has been studied by the SHG technique. This is the first time to our knowledge that the effects of anions on molecular cation transport have been observed. Our studies show four results. First, in the presence of sodium chloride (NaCl) or sodium bromide (NaBr), the time constant for transport of MG across the DOPG bilayer increases with the increase in the concentration of the counterion (i.e., Cl- or Br-). Second, with the organic electrolytes, sodium citrate (NaCitrate) and sodium ethanesulfonate (NaEtSO3), the transport rate is independent of the concentration of the counterion (i.e., Citrate- and EtSO3-). Third, at the same counterion concentration, the transport rate depends on the species of the counterion used. The rate of MG transport is the slowest with Cl-, faster with Br-, and the fastest with the two organic counterions, Citrate- and EtSO3-. Last, at the low counterion concentration of 1mM, the transport rates of MG were found to approach the same value for the four anions. A brief discussion of a possible mechanism is presented.
Surface-Enhanced Raman Scattering of Microorganisms (2007)

A novel metal (Au or Ag) nanoparticle covered substrate has been developed for obtaining surface enhanced Raman scattering (SERS) spectra of vegetative bacterial cells. Species specific vibrational fingerprints are reproducibly observed. These bacterial SERS spectra are metal dependent, exhibit greater species specificity and reduced spectral congestion than nonSERS spectra and show fluorescence quenching. The development of this methodology for the identification and detection of vegetative bacterial cells in human blood is described.
ChemInform Abstract: Hindered Organoboron Groups in Organic Chemistry. Part 22. Some Interesting Properties of 2,4,6‐Triisopropylphenylborane (Tripylborane, TripBH2), a New Useful Monoarylborane. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A simple lens-sparing technique to treat hypotonic maculopathy secondary to large cyclodialysis (2018)

We successfully treated two cases with hypotonic maculopathy by a simple technique with an infusion cannula. This procedure is simple, immediately effective, less invasive, and applicable to all cases including phakic eyes.