gebhart/patrepeval huggingface dataset:
Challenges in presenting high dimensional data to aid in triage in the DARPA virtual soldier project. (2005)

One of the goals of the DARPA Virtual Soldier Project is to aid the field medic in the triage of a casualty. In Phase I, we are currently collecting 12 baseline experimental physiological variables and a cardiac gated Computed Tomography (CT) imagery for use in an prototyping a futuristic electronic medical record, the "Holomer". We are using physiological models and Kalman filtering to aid in diagnosis and predict outcomes in relation to cardiac injury. The physiological modeling introduces another few hundred variables. Reducing the complexity of the above into easy-to-read text to aid in the triage by the field medic is the challenge with multiple display solutions. A description of the possible techniques follows.
Fractionation of DNA from mammalian cells by alkaline elution (1976)

The method of alkaline elution provides a sensitive measure of DNA single-strand length distribution in mamalian cells and is applicable to a variety of problems concerning DNA damage, repair, and replication. The physical basis of the elution process was studied. The kinetics of elution above the alkaline transition pH were found to occur in two phases: an initial phase in which single-strand length is rate limiting, followed by a phase in which elution is accelerated due to the accumulation of alkali-induced strand breaks. The range of DNA single-strand lengths that can be discriminated by elution above the alkaline transition pH was estimated by calibration relative to the effects of x ray, and was found to be 5 X 10(8)-10(10) daltons. Shorter DNA strands elute within the pH transition zone, which extended from pH 11.3 to 11.7 when tetrapropylammonium hydroxide was used as base. This elution was relatively rapid, but was sharply limited by pH, according to the length of the strands: the length of the strands eluted increased with increasing pH. Alkaline elution was inhibited by treatment of cells with low concentrations of nitrogen mustard, a bifunctional alkylating known to cross-link DNA. On investigation of the possibility that DNA subclasses may differ in their elution behavior, satellite L strands were found to elute more slowly from cells exposed to a low dose of x ray than did the bulk DNA.
Oscillation of pain intensity during adenosine infusion. Relationship to β-endorphin and sympathetic tone (2001)

Adenosine is a neuromodulator with both excitatory and inhibitory effects dependent in part upon preconditions; it can act as an algesic or an analgesic agent. Previously we found variations of pain intensity during constant infusion of adenosine. We therefore quantified pain intensity during constant infusion of adenosine at a rate of 140 microg/kg/min intravenously in healthy volunteers, placebo controlled, double blind, and the relation to hemodynamic, vasomotor and sudomotor responses of the sympathetic nervous system and to the role of peripheral beta-endorphin response. The perceived chest pain during adenosine infusion showed an oscillatory pattern. Painful periods of about 30s were interrupted by painfree periods, and pain was always preceded by an increase in vasomotor sympathetic activity and by increased sudomotor activity. Plasma beta-endorphin values were heterogenous but exhibited an increase during infusion.
Is Uncle Sam Inducing the Elderly to Retire (2016)

Social Security was originally created to provide a basic floor for retirees’ living standards. However, many Americans – and in particular an increasing number of Baby Boomers – rely on Social Security as their major source of retirement income. There is a gap between what Social Security can provide at current funding levels, and what Americans expect it to provide. Many Baby Boomers appear at risk of suffering a major decline in their living standard in retirement. Since the government is not likely to expand Social Security in the short term, Baby Boomers should not be discouraged from increasing their lifetime earnings by working harder and longer. In a recent paper, 1 my colleagues and I measure the work disincentives confronted by people aged 50-79, based on an evaluation of the entire array of explicit federal and state taxes and implicit taxes arising from the loss of benefits as one earns more. We find that these work disincentives are much higher than suggested by previous research. Working longer can raise older workers’ living standards, but those additional earnings are effectively taxed at a high rate (typically between 40-60%). Reducing these work disincentives could help increase the lifetime earnings of retirees and thereby reduce poverty rates among the elderly.
A decision feedback based scheme for slepian-wolf coding of sources with hidden markov correlation (2006)

We consider the problem of compression of two memoryless binary sources, the correlation between which is defined by a hidden Markov model (HMM). We propose a decision feedback (DF) based scheme which when used with low density parity check codes results in compression close to the Slepian-Wolf limit.
I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. (1992)

The NF-kappa B transcription factor complex is comprised of two subunits, p50 and p65, that share significant homology to the rel oncogene. We have isolated a cDNA encoding a novel 66-kD rel-related protein, designated I-Rel. Unlike other rel-related proteins, I-Rel does not interact with DNA. I-Rel forms heterodimers with p50, however, and greatly attenuates its DNA-binding activity--an effect probably resulting from the presence of a domain inhibitory to DNA binding present within the 121 amino-terminal residues of I-Rel. In contrast, I-Rel does not associate with p65. Transfection experiments demonstrate that I-Rel suppresses NF-kappa B-induced transcription, probably through its association with p50. Expression of I-Rel mRNA is induced by mitogenic stimulation and accumulates after the appearance of p50 transcripts. Our findings suggest that p50 and I-Rel are components of a feedback pathway where expression of I-Rel may modulate indirectly the expression of genes responsive to the NF-kappa B transcription factor complex.
Influence of Adrenal Steroids upon Testosterone Secretion by the Boar Testis1 (1981)

The effects of porcine adrenocorticotropic hormone (ACTH) upon concentrations of total corticosteroids, progesterone, testosterone, and luteinizing hormone (LH) in peripheral serum and upon LH-induced changes in testosterone were studied in 15 boars and 5 barrows. Boars were assigned to either ACTH-saline, ACTH-LH, or saline-LH treatments while all barrows received ACTH-LH. The relationship between physiological concentrations of corticosteroids and testosterone during a 12 h control period was determined prior to ACTH treatment. The relationship between endogenous production of testosterone during this 12 h period and the ability of boars to produce testosterone after ACTH was also determined.
Physiology and Pathobiology of Microvascular Endothelium (2008)

The sections in this article are: 1 Microvascular ECs: Morphological Features and Markers 2 Physiological Functions of ECs at Rest 3 Type I Activation of Endothelium 4 Type II Activation of ECs 5 Immune-Mediated Activation of ECs 6 Endothelial Dysfunction, Injury and Cytoprotection 7 ECs and Chronic Inflammation 8 Summary
Overview and Evaluation of a Computational Bone Physiology Modeling Toolchain and Its Application to Testing of Exercise Countermeasures (2018)

Prolonged microgravity exposure disrupts natural bone remodeling processes and can lead to a significant loss of bone strength, increasing injury risk during missions and placing astronauts at a greater risk of bone fracture later in life. Resistance-based exercise during missions is used to combat bone loss, but current exercise countermeasures do not completely mitigate the effects of microgravity. To address this concern, we present work to develop a personalizable, site-specific computational modeling toolchain of bone remodeling dynamics to understand and estimate changes in volumetric bone mineral density (BMD) in response to microgravity-induced bone unloading and in-flight exercise. The toolchain is evaluated against data collected from subjects in a 70-day bed rest study and is found to provide insight into the amount of exercise stimulus needed to minimize bone loss, quantitatively predicting post-study volumetric BMD of control subjects who did not perform exercise, and qualitatively predicting the effects of exercise. Results suggest that, with additional data, the toolchain could be improved to aid in developing customized in-flight exercise regimens and predict exercise effectiveness.
Development of a human blood type detection automatic system (2010)

This paper presents the development of a low cost image processing system that allows the determination of human blood types. To determine the blood types it was used the plate test that consist of the mixture serums specifics of blood types determination and the sample blood of the donor. The mixtures blood/serums are captured through a CCD camera and analyzed using the software IMAQ Vision from National Instruments. The presented approach allows improving the public health efficiency as there is not yet available low-cost commercial equipment to determine blood types in an emergency situation.
High-Throughput Exploration of Lithium-Alloy Protection Layers for High-Performance Lithium-Metal Batteries (2020)

To realize high specific capacity Li-metal batteries, a protection layer for the Li-metal anode is needed. We are carrying out combinatorial screening of Li-alloy thin films as the protection layer which can undergo significant lithiation with minimum change in volume and crystal structure. Here, we have fabricated lithium-free binary alloy thin film composition spreads of Co 1-xSnx on Cu layers on Si substrates. The crystallinity of the thin films was tuned by varying the deposition temperature followed by electrochemical lithiation to form Li-alloy ternary thin films. Synchrotron diffraction is used as the main tool to investigate the crystallinity of the films before and after lithiation. Co 3Sn2 alloy thin films are found to exhibit significant lithium uptake capacity while maintaining its structural integrity, and are thus a good candidate of the Li-metal protection layer.
Distributed Column Subset Selection on MapReduce (2013)

Given a very large data set distributed over a cluster of several nodes, this paper addresses the problem of selecting a few data instances that best represent the entire data set. The solution to this problem is of a crucial importance in the big data era as it enables data analysts to understand the insights of the data and explore its hidden structure. The selected instances can also be used for data preprocessing tasks such as learning a low-dimensional embedding of the data points or computing a low-rank approximation of the corresponding matrix. The paper first formulates the problem as the selection of a few representative columns from a matrix whose columns are massively distributed, and it then proposes a MapReduce algorithm for selecting those representatives. The algorithm first learns a concise representation of all columns using random projection, and it then solves a generalized column subset selection problem at each machine in which a subset of columns are selected from the sub-matrix on that machine such that the reconstruction error of the concise representation is minimized. The paper then demonstrates the effectiveness and efficiency of the proposed algorithm through an empirical evaluation on benchmark data sets.
Assessment of the Potential for Drug–Drug Interactions Between INP104 and Gepants for Migraine Management Using a Model-based Approach (P12-12.008) (2023)

To predict whether coadministration of INP104 and gepants for migraine management results in potential drug–drug interactions (DDIs).
A novel approach to all-optical switching based on second-order nonlinearities (1992)

Materials with large and fast third-order nonlinearities and low losses have proven difficult to find and use in all-optical switching device configurations. Large nonlinear phase shifts, however, can be obtained in non-centrosymmetric materials relying on a cascaded second-order effect, i.e. up-conversion of a fundamental beam into its second-harmonic and the subsequent down-conversion for a phase-mismatched interaction.[1-2] Because of the recent development of efficient second harmonic generation in waveguides, it appears that phase shifts of order π can be reached over centimeter distances with peak powers of 10's of Watts or less in KTP or poled polymers, an improvement of orders of magnitude over the current capabilities of third order materials.
22.1: Invited Paper : High‐Luminance Carbon Nanotube FED (2000)

Abstract An excellent performance of carbon‐nanotubes as field‐emitters was demonstrated using a high‐voltage FED elements at SID in 1998 where a light‐source tube for outdoor large size display and diode type flat panel were presented with the screen printed nanotube cathode. After that, a triode type paper which describes an x‐y addressable high‐luminance FED panel was introduced at IDRC in 1999. The experimental panel was performed ca.7×105 cd/m 2 green light at 6kV, ca.1mA/cm 2 dc‐driving condition.[2] The results show the excellent performance of carbon nanotube FED as flat panel displays which are applicable to large size TV devices. This panel will be not only suitable for future TV display but also light‐sources for field sequential color LCDs.
A note on iterative fourier transform phase reconstruction from magnitude (1984)

In this correspondence, a well-known iterative procedure for Fourier transform phase reconstruction from magnitude (usually referred to as the Gerchberg-Saxton-Fienup procedure) is revisited. The convergence of this algorithm has raised some controversy in the recent literature. In this correspondence we first point out a potential source of error in the numerical implementation of the algorithm. Then, we present a conjecture which would explain why this algorithm sometimes fails.
A new entry to pyrazolo[4,3-e][1,4]diazepines. Facile synthesis of pyrazolo [4,3-e][1,4]diazepin-5,8-diones, 5,6,8-triones and pyrazolo[4,3-e]pyrrolo-[1,2-a][1,4]diazepin-5,10-diones (2005)

A facile approach to pyrazolo[4,3-e][1,4]diazepin-5,8-diones and pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]-diazepin-5,10-diones is reported. Strategy involved the utility of α-amino acid as a three-atom segment in the construction of diazepine skeleton on the preformed pyrazole ring.
Diabetes incidence before and after COVID-19 vaccination – Results from the German Disease Analyzer database (2023)

Our study did not confirm an increased risk of diabetes after COVID-19 vaccination. Further studies are needed to show whether the vaccination may be associated with a reduced diabetes risk.
The Effect of a Cementless Stem Cross-Sectional Shape on Mechanical Stability: A Finite Element Analysis approach (2015)

The standard cementless femoral stems commercially available may not be the best-fit to a patient in markets like India, because of the large anatomic variation of the human hip joint among the population. This investigation presents a regional anthropometric data based design approach for the standard anatomical cementless femoral component used in total hip replacement (THR). Aseptic loosening and dislocation are the most important causes of failure of THR due to the mismatch in dimensions between the femur bone and stem. Standard cementless stems with different cross-section shapes were designed and analyzed to solve the problem of a possible geometric mismatch between a selected implant and the hip joint considering a variety of patients with differing anatomical sizes. Finite element analysis was conducted on cementless tapered stems with four different stem cross-sectional shapes -oval, trapezoidal, rectangular and wedge. Comparison of Von Mises stresses and micromotion under axial and torsional loads were made. This study indicates a need for a regional anthropometric data based design of cementless femoral stems for providing greater longevity and better recovery to patients. This novel design approach can improve the implant fixation enhancing primary stability, rigidity, longevity of the implant and relieving patients from discomfort.
Escape analysis for Java (1999)

This paper presents a simple and efficient data flow algorithm for escape analysis of objects in Java programs to determine (i) if an object can be allocated on the stack; (ii) if an object is accessed only by a single thread during its lifetime, so that synchronization operations on that object can be removed. We introduce a new program abstraction for escape analysis, the connection graph , that is used to establish reachability relationships between objects and object references. We show that the connection graph can be summarized for each method such that the same summary information may be used effectively in different calling contexts. We present an interprocedural algorithm that uses the above property to efficiently compute the connection graph and identify the non-escaping objects for methods and threads. The experimental results, from a prototype implementation of our framework in the IBM High Performance Compiler for Java, are very promising. The percentage of objects that may be allocated on the stack exceeds 70% of all dynamically created objects in three out of the ten benchmarks (with a median of 19%), 11% to 92% of all lock operations are eliminated in those ten programs (with a median of 51%), and the overall execution time reduction ranges from 2% to 23% (with a median of 7%) on a 333 MHz PowerPC workstation with 128 MB memory.
Optical resolution of some biologically active compounds by chiral liquid chromatography on BSA‐silica (resolvosil) columns (1989)

Abstract Optical resolution on the analytical scale of a number of racemic pharmaceuticals and some other biologically active compounds has been studied using immobilized bovine serum albumin (BSA) as the stationary phase. For some of the compounds the elution order was determined by the use of optically enriched fractions obtained from a preceding passage of a sample through a preparative column containing microcrystalline triacetylcellulose (MCTA). The reversal in the sign of optical rotation shown in the polarimetric elution profile from the latter, combined with the integrated peak area ratio obtained on resolution on the analytical column, gave directly the order of elution. For one of the benzothiadiazines studied (bendroflumethiazide), increasing the pH of the mobile phase produced opposite effects on the retention of the two enantiomers, leading to a large effect on the separation factor. For many of the compounds studied, high separation factors (α &gt; 2) could be achieved.
Event-driven detectors for soft x-ray astronomy (2019)

We discuss the joint development by Penn State University (PSU) and Teledyne Imaging Systems (TIS) of hybrid CMOS detectors for X-ray astronomy, and specifically the development over the past 10 years of a new event-driven X-ray detector for future astronomy missions. This novel X-ray detector is designed to perform onchip event recognition and to read out only pixels containing X-ray events. With the exception of analog power supply voltages, the detector is digital in/digital out, reducing off-chip electronics to a minimum. It operates at frame rates of over 1000 frames per second, providing excellent performance for bright X-ray sources and/or high-throughput optics. The pixel size is 40 &times; 40 microns, and we are fabricating devices with 550 &times; 550 pixels.
Supplementary Figure 1 from Ectopic ATP Synthase Blockade Suppresses Lung Adenocarcinoma Growth by Activating the Unfolded Protein Response (2023)

&lt;p&gt;PDF file, 110K, Distribution of respiratory chain complexes in A549 and CL1-0 cells.&lt;/p&gt;
Oxidative Stress and Antioxidant Treatment in Hypertension and the Associated Renal Damage (2005)

Reactive oxygen species (ROS) are elevated in humans with hypertension many of which develop end-stage renal disease (ESRD), and antioxidant capacity is decreased. About one-half of essential hypertensives have a salt-sensitive type of hypertension, and the amount of renal damage that occurs in salt-sensitive hypertensives greatly exceeds that of non-salt-sensitive hypertensives. Antioxidant therapy can improve cardiovascular outcomes in humans but only if sufficient doses are used. Salt-sensitive hypertensive animal models, especially Dahl salt-sensitive rats, have been used to investigate the relationship between hypertension, ROS and end-stage renal damage. In experimental salt-sensitive hypertension, ROS increase and significant renal damage occur. In the Dahl salt-sensitive (S) rat on high Na for 3 weeks, renal damage is mild, renal levels of superoxide dismutase are decreased, and treatment with Tempol reduces arterial pressure. In the Dahl S rat on high Na for 5 weeks, renal damage is severe, GFR and renal plasma flow are decreased, and renal superoxide production is high. Treatment with vitamins C and E decreases renal superoxide production and renal damage and prevents the decrease in renal hemodynamics. Antioxidant treatment reduces arterial pressure, aortic superoxide production and renal inflammation in DOCA-salt rats, and decreases blood pressure and aortic superoxide release and increases bioactive nitric oxide in SHR stroke-prone rats. In conclusion, in both human and experimental salt-sensitive hypertension, superoxide production and renal damage are increased, antioxidant capacity is decreased, and antioxidant therapy can be helpful.
Nocturnal heart rate variability moderates the association between sleep–wake regularity and mood in young adults (2019)

Irregular sleep-wake timing appears to precede poor mood in young adults. Further work is needed to understand the implications of high nocturnal HRV in those with low mood and irregular sleep-wake cycles.
Solvent-Separated Ion Pairs of Carbanions (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvent-Separated Ion Pairs of CarbanionsT. E. Hogen-Esch and J. SmidCite this: J. Am. Chem. Soc. 1965, 87, 3, 669–670Publication Date (Print):February 1, 1965Publication History Published online1 May 2002Published inissue 1 February 1965https://pubs.acs.org/doi/10.1021/ja01081a059https://doi.org/10.1021/ja01081a059research-articleACS PublicationsRequest reuse permissionsArticle Views325Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts