gebhart/patrepeval huggingface dataset:
Effects of Oral Testosterone Undecanoate (Kyzatrex) Versus Testosterone Gel (Androgel) on Long-Term (to 12 Months) Blood Pressure Levels (2022)

Purpose: Oral and injectable testosterone replacement therapies have been reported to increase blood pressure (BP) in hypogonadal men. Less is known about the effects of topical testosterone formulations on BP. Materials and Methods: We studied the effects of a new oral testosterone undecanoate (TU) (Kyzatrex™) and a topical testosterone gel (Androgel™) on BP and heart rate, in a 2:1 randomized trial of men with hypogonadism. Digital BPs and clinical assessments were obtained at baseline and at 90, 180 and 365 days. Results: There were 314 men randomized (mean age 49.7 years, 82% white, and 35% with treated hypertension). The mean changes from baseline in systolic BP were 2.2 mmHg (95% confidence interval [CI] 0.6–3.7) on the oral TU and 3.1 mmHg (95% CI 1.0–5.1) on the topical testosterone at 90 days. Similar findings were seen after 180 and 365 days. Heart rate increased by 4.3 and 2.7 beats/min at 90 days on oral and topical testosterone, respectively. For those men with treated hypertension, changes in systolic BP in the oral TU group were higher compared with those without hypertension, whereas those on topical testosterone had similar increases in systolic BP regardless of hypertension status. Outlier analyses for systolic BP at 90 days demonstrated a higher proportions of subjects with increases of 5 and 10 mmHg postbaseline on topical testosterone gel versus this oral TU. Conclusions: These data demonstrate that the overall effects of the oral TU on BP were comparable with a topical testosterone. In men without hypertension, the oral TU induced smaller changes in BP compared with topical testosterone. Clinical Trial Registration ( https://www.clinicaltrials.gov/ ) : NCT04467697.
The Functional Role of CrkII in Actin Cytoskeleton Organization and Mitogenesis (1999)

Crk is a member of a family of adapter proteins predominantly composed of Src homology 2 and 3 domains, whose role in signaling pathways is presently unclear. Using an in situ electroporation system which permits the introduction of glutathione S-transferase (GST) fusion proteins into cells, we found that c-CrkII bound to p130(cas), but not to paxillin in serum-starved rat-1 fibroblasts overexpressing the human insulin receptor (HIRc cells) in vivo. 17 nM insulin stimulation dissociated the binding of c-CrkII to p130(cas), whereas 13 nM insulin-like growth factor-I, 16 nM epidermal growth factor (EGF), and 10% serum each showed little or no effect. We found that stress fiber formation is consistent with a change in the p130(cas).c-CrkII interactions before and after growth factor stimulation. Microinjection of either GST-Crk-SH2 or -Crk-(N)SH3 domains, or anti-Crk antibody each inhibited stress fiber formation before and after insulin-like growth factor-I, EGF, and serum stimulation. Insulin stimulation by itself caused stress fiber breakdown and there was no additive effect of microinjection. Microinjection of anti-p130(cas) antibody also blocked stress fiber formation in quiescent cells. Microinjection of the Crk-inhibitory reagents also inhibited DNA synthesis after insulin-like growth factor-I, EGF, and serum stimulation, but not after insulin. These data suggest that the complex containing p130(cas).c-CrkII may play a crucial role in actin cytoskeleton organization and in anchorage-dependent DNA synthesis.
Data from Adoptive Transfer of MAGE-A4 T-cell Receptor Gene-Transduced Lymphocytes in Patients with Recurrent Esophageal Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Preparative lymphodepletion, the temporal ablation of the immune system, has been reported to promote persistence of transferred cells along with increased rates of tumor regression in patients treated with adoptive T-cell therapy. However, it remains unclear whether lymphodepletion is indispensable for immunotherapy with T-cell receptor (TCR) gene–engineered T cells.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We conducted a first-in-man clinical trial of TCR gene-transduced T-cell transfer in patients with recurrent MAGE-A4–expressing esophageal cancer. The patients were given sequential MAGE-A4 peptide vaccinations. The regimen included neither lymphocyte-depleting conditioning nor administration of IL2. Ten patients, divided into 3 dose cohorts, received T-cell transfer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; TCR-transduced cells were detected in the peripheral blood for 1 month at levels proportional to the dose administered, and in 5 patients they persisted for more than 5 months. The persisting cells maintained &lt;i&gt;ex vivo&lt;/i&gt; antigen-specific tumor reactivity. Despite the long persistence of the transferred T cells, 7 patients exhibited tumor progression within 2 months after the treatment. Three patients who had minimal tumor lesions at baseline survived for more than 27 months.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These results suggest that TCR-engineered T cells created by relatively short-duration &lt;i&gt;in vitro&lt;/i&gt; culture of polyclonal lymphocytes in peripheral blood retained the capacity to survive in a host. The discordance between T-cell survival and tumor regression suggests that multiple mechanisms underlie the benefits of preparative lymphodepletion in adoptive T-cell therapy. &lt;i&gt;Clin Cancer Res; 21(10); 2268–77. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
The Nutraceutical Properties of Ovotransferrin and Its Potential Utilization as a Functional Food (2015)

Ovotransferrin or conalbumin belong to the transferrin protein family and is endowed with both iron-transfer and protective activities. In addition to its well-known antibacterial properties, ovotransferrin displays other protective roles similar to those already ascertained for the homologous mammalian lactoferrin. These additional functions, in many cases not directly related to iron binding, are also displayed by the peptides derived from partial hydrolysis of ovotransferrin, suggesting a direct relationship between egg consumption and human health.
Tool advances pipe location and construction planning (1997)

Ground Penetrating Radar (GPR) has long been used by the scientific community to develop an image of below-ground environments. Systems have been developed where a device containing minimal sensing electronics is controlled by an operator, with an umbilical cable to a van full of instruments and scientists to analyze the signals. A robust single-unit development of GPR has now been developed for the utility industry, offering a method of locating buried piping of any material, without excavation. Pipe Hawk{trademark} is the result of a seven-year development effort financed by companies of the New York state gas industry through a shared resources R and D consortium, NYGAS. GPR is not a new technology, but it requires the power of modern digital signal processing if it is to distinguish signals reflected by metallic and non-metallic pipes and cables from those of other ground clutter such as soda cans, stones and construction debris. Pipe Hawk required further development of hardware and software, both interacting strongly with field measurements. The result is a self-contained cart enclosing a 24v battery pack, an electronics module which includes a 486 processor and hard disk plus pulse transmitter, an RF antenna and a liquid crystal display panel. Itsmore » pneumatic-tire wheels trigger a sequence of pulses as the device is pushed along the ground.« less
Dynorphin immunocytochemical localization in brain and peripheral nervous system: preliminary studies. (1981)

Using antisera specific for the opioid peptide dynorphin, we have carried out immunocytochemical studies of the distribution in rat brain and periphery. In the central nervous system, cells that stain positively for dynorphin are found in the supraoptic nucleus, with less-well-stained cells in the paraventricular nucleus of the hypothalamus. Few positive fibers were detected in brain, suggesting problems with fixation and preservation of antigenicity. In pituitary no staining was seen in the anterior and intermediate lobes but heavy staining was detected in the posterior lobe. In the guinea pig, adrenal chromaffin cells stained with dynorphin antisera. Staining of these cells could be blocked with excess of dynorphin-(1-13) or either enkephalin. Radioimmunoassays revealed a great excess of the enkephalins in the adrenal, suggesting cross competition between dynorphin antiserum and adrenal medullary enkephalin. Finally, the dynorphin antiserum stained a complex of fibers in guinea pig ileum. Staining of these fibers could be blocked by moderate amounts of enkephalin as well as by smaller amounts of dynorphin-(1-13). We conclude that in some places (brain and pituitary) dynorphin exists separately from leucine-enkephalin. In other parts of brain and in the periphery the relationship between dynorphin and the enkephalins is very complex and requires further study and improved antisera.
High‐Throughput Synthesis of Mixed‐Metal Electrocatalysts for CO2 Reduction (2017)

Abstract The utilization of CO 2 as a feedstock requires fundamental breakthroughs in catalyst design. The efficiencies and activities of pure metal electrodes towards the CO 2 reduction reaction are established, but the corresponding data on mixed‐metal systems are not as well developed. In this study we show that the near‐infrared driven decomposition (NIRDD) of solution‐deposited films of metal salts and subsequent electrochemical reduction offers the unique opportunity to form an array of mixed‐metal electrocatalyst coatings with excellent control of the metal stoichiometries. This synthetic method enabled us to develop an empirical structure–property correlation to help inform the development of optimized CO 2 catalyst compositions.
Power allocation over time‐varying multi‐user multi‐relay amplify‐and‐forward networks (2016)

In this study, power allocation over time‐varying multi‐user multi‐relay amplify‐and‐forward networks is studied. Specifically, stochastic network sum‐rate, max–min rate power allocation and total power minimisation problems are formulated. However, solving such stochastic problems relies on perfect global instantaneous channel state information (CSI), and thus entails complex computations and excessive communication overheads. To circumvent these issues, second‐order statistics of the CSI (i.e. partial CSI) are utilised to transform the stochastic formulations into deterministic optimisation problems in terms of ergodic capacity while satisfying quality‐of‐service constraints via target outage probability. The obtained optimal deterministic problems are non‐convex and thus are computationally prohibitive. However, at high enough signal‐to‐noise ratio, such problems can be transformed into asymptotically convex ones, and thus solved efficiently. Simulation results illustrate that the proposed approximate deterministic power allocation reformulations closely agree with their optimal exact deterministic and dynamic counterparts.
GDNF Expression in Terminal Schwann Cells Associated With the Periodontal Ruffini Endings of the Rat Incisors During Nerve Regeneration (2009)

The terminal Schwann cells (TSCs) which play crucial roles in regeneration of the periodontal Ruffini endings (RE) exhibit immunoreaction for glial cell line-derived neurotrophic factor (GDNF). However, no information is available regarding the role of GDNF in the periodontal RE during nerve regeneration. This study was undertaken to examine the changes in GDNF expression in the rat periodontal RE following transection of the inferior alveolar nerve (IAN) using immunohistochemistry for GDNF and S-100 protein, a marker for the TSCs. We additionally investigated the changes in expression of GDNF in the trigeminal ganglion (TG) at protein and mRNA levels. A transection to IAN induced a disappearance of the TSCs from the alveolus-related part (ARP), followed by a migration of spindle-shaped cells with S-100 but without GDNF immunoreactions into the tooth-related part (TRP) by postoperative (PO) week 2. At PO week 2, GDNF immunoreacted cellular elements increased in number in the ARP although the spindle-shaped cells without GDNF reaction remained in the TRP. After PO week 4, many GDNF-positive TSCs appeared in the ARP though the spindle-shaped cells vanished from the TRP. A real time RT-PCR analysis demonstrated the highest elevation of GDNF mRNA in the TG at PO week 2. These findings suggested the involvement of this molecule in the maturation and maintenance of the periodontal RE during regeneration. Taken together with our previous and current studies, it appears that the regeneration of the periodontal RE is controlled by multiple neurotrophins in a stage-specific manner.
CD3 and CD20 Expression in Titanium vs Zirconia Peri-Implant Soft Tissues: A Human Study (2013)

The aim of this study was to investigate the presence of an inflammatory infiltrate in the peri-implant soft tissue of single-implant crowns supported by either zirconia or titanium abutments in healthy subjects. Serial sections from formalin-fixed, paraffin-embedded blocks from peri-implant mucosa of 25 patients were immunohistochemically analyzed for CD3 and CD20 lymphocyte marker expression. The results showed that levels of T cells (CD3) were higher around zirconia than titanium abutments (p&lt;0.05). On the contrary, the levels of B cells (CD20) were found higher around titanium abutment in comparison with the zirconia abutment. These differences were statistically significant (p&lt;0.05).
Primitive operator digital filter synthesis using a shift biased algorithm (2003)

A graph-based synthesis technique has been developed which allows digital filters to be realized with significantly reduced numbers of primitive arithmetic operations. Previously presented work has relied on the use of unity-gain graph edges. These methods are extended by the authors to permit the inclusion of edges with gains which may assume any power of two. This facilitates a tradeoff between addition or subtraction and shift operations which can be beneficial in many implementations. For VLSI implementations especially, judicious placement of processing elements, routing, and allocation of pipeline registers, make for an efficient filter implementation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Effects of Influence Parameters on Color Formation in Glucose Syrups during Storage (2010)

Effects of pH, temperature, and syrup concentration on color formation in glucose syrups were studied and the shelf life of syrups under various conditions was estimated. Temperatures of 5, 25, and 45 oC, pH values of 4, 5, and 6 as well as concentrations of 30, 40, 50, 60, 70, and 80 oBrix were examined. After 26 weeks no significant color changes were observed at 5 oC. At 45 oC, color formation rate was highest and after 2 weeks color changes were visible, and at 15th week syrup color was completely brown. At 25 oC, color formation rate was low and at week 18 color changes were visible. At pH 5, rate of browning was lower than at other pH values. Increasing the syrup concentration up to 70 oBrix enhanced the color formation rate but higher concentrations decreased the color formation rate. The kinetics of color formation was studied and rate constants and activation energies were calculated.
Quality Characteristics of Fermented Wild Grass Juice (2014)

산야초와 설탕의 비율을 1:1(w/w)로 혼합하는 전통적인 방법으로 달맞이꽃, 오행초, 옻의 발효액을 제조하여 상온에서 6개월간 발효 및 숙성 중 품질 특성, 효소 활성, 항산화 활성의 변화를 조사하였다. 모든 실험구에서 발효기간 중 당도는 감소하였으며, 점도는 발효 3개월까지 증가하다가 숙성기간 중 감소하였다. 3개월의 발효기간 중 pH는 낮아졌고 적정산도는 높아졌으나, 3개월의 숙성기간 중에는 뚜렷한 변화를 나타내지 않았다. 미생물의 변화는 발효 1개월 이후 6개월 동안 점차 감소하는 경향을 나타내었으며, 유산균의 경우 전 기간 동안 검출되지 않았다. 전통적인 방법으로 제조한 산야초 발효액의 invertase, amylase, cellulase 활성은 발효 및 숙성 전 기간 동안 매우 낮은 활성을 나타내었고, 시중에 판매되고 있는 5종의 산야초 발효액 모두 매우 낮은 효소활성(1 unit 이하)을 나타내었다. 총 폴리페놀 함량은 발효기간 중 증가하다가 숙성기간 동안 일정하게 유지되었으며, 그중 달맞이꽃 발효액의 폴리페놀 함량(6.40 mg/mL)과 DPPH radical 소거능(40.52%)이 가장 높았다.
A microporous metal–organic framework with both open metal and Lewis basic pyridyl sites for highly selective C2H2/CH4and C2H2/CO2gas separation at room temperature (2012)

To immobilize both open metal and Lewis basic pyridyl sites into a microporous metal–organic framework, Cu6(PDC)6·2.6H2O (UTSA-50) was solvothermally synthesized and characterized. The combination of open metal sites and Lewis basic pyridyl functional sites leads to a high acetylene adsorption enthalpy of 39.4 kJ mol−1. As a result, UTSA-50 is a very promising MOF material for the highly selective separation of C2H2/CH4 and C2H2/CO2 at room temperature with the highest C2H2/CH4 separation selectivity of 68 ever reported and moderately high acetylene uptake of 91 cm−1 g−1.
Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs (2014)

The present studies examined the toxic interaction between the non-coxib celecoxib derivative OSU-03012 and phosphodiesterase 5 (PDE5) inhibitors, and also determined the roles of endoplasmic reticulum stress response regulators in cell survival. PDE5 inhibitors interacted in a greater than additive fashion with OSU-03012 to kill parental glioma and stem-like glioma cells. Knockdown of the endoplasmic reticulum stress response proteins IRE1 or XBP1 enhanced the lethality of OSU-03012, and of [OSU-03012 + PDE5 inhibitor] treatment. Pan-caspase and caspase-9 inhibition did not alter OSU-03012 lethality but did abolish enhanced killing in the absence of IRE1 or XBP1. Expression of the mitochondrial protective protein BCL-XL or the caspase-8 inhibitor c-FLIP-s, or knockdown of death receptor CD95 or the death receptor caspase-8 linker protein FADD, suppressed killing by [OSU-03012 + PDE5 inhibitor] treatment. CD95 activation was blocked by the nitric oxide synthase inhibitor L-NAME. Knockdown of the autophagy regulatory proteins Beclin1 or ATG5 protected the cells from OSU-03012 and from [OSU-03012 + PDE5 inhibitor] toxicity. Knockdown of IRE1 enhanced OSU-03012/[OSU-03012 + PDE5 inhibitor]-induced JNK activation, and inhibition of JNK suppressed the elevated killing caused by IRE1 knockdown. Knockdown of CD95 blunted JNK activation. Collectively, our data demonstrate that PDE5 inhibitors recruit death receptor signaling to enhance OSU-03012 toxicity in glioblastoma multiforme (GBM) cells.
Functionalized Mesoporous Silicates for the Removal of Ruthenium from Reaction Mixtures (2006)

[reaction: see text] The removal of residual ruthenium after olefin metathesis reactions and asymmetric hydrogenations has been described using amine-functionalized mesoporous silicates. Aminopropyltriethoxy silane-derivatized silicates were found to be the most effective. More than 99.99% of RuCl(3) could be removed in a single treatment. Scavenging of Ru after metathesis reactions using a Grubbs generation 1 catalyst gave a product with concentrations of less than 10 microg/5 mg after two treatments with amine-modified silica. Most importantly, no chromatography was required.
GraalVM: metaprogramming inside a polyglot system (invited talk) (2018)

GraalVM is a polyglot virtual machine for running applications written in a variety of languages such as JavaScript, Ruby, Python, R, JVM-based languages like Java, Scala, Kotlin, and LLVM-based languages such as C and C++.
The science of adverse childhood experiences (2017)

A recently released one-hour documentary follows a group of paediatricians, therapists, educators, and communities, who are devising and using practical techniques to combat what is known as ‘toxic stress’.
Second line chemotherapy and visceral metastases are associated with poor survival in patients with mCRPC receiving 177Lu-PSMA-617 (2019)

The aim of the study was to identify prognostic parameters predicting overall survival (OS) of patients with metastatic castration-resistant prostate cancer (mCRPC) receiving 177Lu-PSMA-617 therapy with respect to their previously received treatments and biomedical marker profile.
An investigation of the uroselective properties of four novel alpha(1a)-adrenergic receptor subtype-selective antagonists. (2000)

The development of alpha(1a)-adrenergic receptor (AR) subtype-selective antagonists is likely to result in uroselective agents that effectively treat benign prostatic hyperplasia (BPH) symptoms without causing undesirable side effects that may be due to vascular alpha(1)-AR blockade. The properties of four aryl piperazine compounds (RWJ-38063, RWJ-68141, RWJ-68157, and RWJ-69736) are described in this report and compared with the properties of tamsulosin, an alpha(1)-AR antagonist that is used in the treatment of BPH. Radioligand binding studies show that all four RWJ compounds have significantly higher affinity for the alpha(1a)-AR subtype than for the alpha(1b) or alpha(1d) subtype and display a higher level of receptor subtype selectivity than tamsulosin. The RWJ compounds were more potent in inhibiting (+/-)-norepinephrine-induced contractions of isolated rat prostate tissue than those of isolated rat aorta tissue, whereas tamsulosin had the reversed tissue selectivity. RWJ-38063 and RWJ-69736 had the highest potency in the isolated prostate tissue assays of the four RWJ compounds, with pK(B) values of 8.24 and 9.26, respectively, and were 319- and 100-fold more potent in their effects on isolated prostate tissue than aorta tissue. The in vivo uroselectivities of RWJ-38063, RWJ-69736, and tamsulosin were examined in anesthetized dogs. Both RWJ compounds suppressed the intraurethral pressure response to phenylephrine to a greater extent than the mean arterial pressure response; however, RWJ-69736 also caused a marked transient rise in heart rate. Although less potent, RWJ-38063 and RWJ-69736 were notably more uroselective than tamsulosin in this canine model.
Plasmablastic Richter transformation as a resistance mechanism for chronic lymphocytic leukaemia treated with BCR signalling inhibitors (2016)

The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.
Regio- and stereoselective synthesis of carbo- and heterocycles from 2-phenylsulfonyl 1,3-dienes (1994)

Regio- and stereoselective synthesis of carbo- and heterocycles from 2-phenylsulfonyl 1,3-dienes
Measurements of Asperity Temperatures of a Read/Write Head Slider Bearing in Hard Magnetic Recording Disks (1991)

An infrared temperature measurement system was used to measure hot spots in a magnetic head rigid disk interface. The system employed the spectral distribution as well as intensity of sampled radiation to determine both the temperature and effective area of microscopic sources at elevated temperature. Flash temperatures between particulate and thin-film rigid disks and a simulated transparent sapphire slider at various operating conditions were measured.
Quorum Sensing System Lactones Do Not Increase Invasiveness of a MexAB‐OprM Efflux Mutant but Do Play a Partial Role in Pseudomonas aeruginosa Invasion (2006)

We studied the quorum sensing (QS) system and the related homoserine lactones (HSLs) observing Pseudomonas aeruginosa invasion using the epithelial cell monolayer penetration assay model. Compared to the PAO1 wild-type, the QS mutants, DeltalasI and DeltarhlI, were compromised in their capacity to invade. The decreased invasiveness of DeltarhlI was restored by adding 100 microM exogenous C(4)-HSL. However, the decreased invasiveness of an efflux mutant, DeltamexAB-oprM, was not restored in the presence of exogenous HSLs. The QS system partially plays a role in P. aeruginosa invasion; however, C(4)-HSL and 3-O-C(12)-HSL are not the essential determinants for invasiveness for P. aeruginosa.