gebhart/patrepeval huggingface dataset:
Using application understanding to support impact analysis (1998)

Any change to one component of a software system is likely to be felt in other components, a phenomenon known as ‘ripple effect’. Impact analysis is the process of identifying all those components of a system which may be affected by ripple effect. This requires a knowledge of the dependencies between components. A software system consists not only of the source code, but also of all life cycle work products including requirements, design and test documents. Any of these components may be the subject of a change request, and should therefore be included in impact analysis. The ripple propagation graph (RPG) for impact analysis, developed as part of the AMES (Application Management Environments and Support) project, models an application in such a way that dependencies can be traced in order to identify all affected components. It is an object-relationship model consisting of the components of a system at some level of granularity, and the various relationships between them. This paper describes the AMES RPG, and how the results of the application understanding (AU) toolset, developed (again as part of the AMES project) to support the process of gaining an understanding of an application, can be used to provide some of the data required to populate the RPG. © 1998 John Wiley & Sons, Ltd.
Pilot findings of a cluster randomized trial of non-pharmaceutical interventions for influenza prevention in households in Hong Kong (2008)

Background: There are sparse data on the efficacy of non-pharmacological interventions for&#13;\nprevention of influenza virus transmission. We implemented a pilot study of the feasibility and efficacy of&#13;\nmasks and hand hygiene to reduce transmission in Hong Kong households (February to September&#13;\n2007) as part of a larger community trial planned for 2008. Methods: We conducted a cluster randomized controlled trial of households (composed of at least 3 members) where an index subject presented with&#13;\ninfluenza-like-illness of &lt;48-hour duration. After confirmation as influenza by the QuickVue Influenza A+B&#13;\nrapid test, the household was randomized to 1) control group or 2) surgical masks or 3) hand hygiene.&#13;\nHouseholds were visited within 36 hours, and again 3, 6 and 9 days later. Nose and throat swabs were&#13;\ncollected from index subjects and household contacts at each home visit and tested by viral culture. The&#13;\nprimary outcome measure was laboratory confirmed influenza in a household contact; secondary&#13;\noutcome was clinical influenza (by self-reported symptoms). Results: We randomized 198 households&#13;\nand completed follow up home visits in 128 households. There were 23 household contacts with&#13;\nlaboratory confirmed influenza and 41 with clinical influenza, corresponding to secondary attack ratios of&#13;\n4% and 8% respectively. The secondary attack ratios did not significantly differ across the intervention&#13;\ngroups. In multivariable regression models, history of influenza vaccination and younger age of the&#13;\ncorresponding index subject were associated with lower risk of secondary infection, but were not&#13;\nstatistically significant at the 0.05 level. Conclusions: The secondary attack ratios were lower than&#13;\nanticipated, and lower than in previous studies in Western settings, perhaps due to differing patterns of&#13;\nsusceptibility, lack of significant viral strain drift, and/or issues related to the symptomatic recruitment&#13;\ndesign.
A stripline kicker driver for the next generation light source (2014)

Diversified Technologies, Inc. (DTI) has designed, built, and demonstrated a prototype stripline kicker driver capable of less than 10 ns rise and fall time, ~40 ns pulse length, and peak power greater than 1.7 MW/pulse.
Visual detection of potassium by a cyanine dye supramolecular aggregate responsive to G-quadruplex motif transition (2012)

A supramolecular probe is designed for visual detection of potassium based on a novel cyanine dye aggregate recognizing the motif transition of telomeric G-quadruplexes under the Na(+) background. The practical application for colorimetric measurement of urine potassium has been tested.
Phenotype and outcome of pulmonary arterial hypertension patients carrying aTBX4mutation (2020)

PAH due to <i>TBX4</i> mutations may occur with or without skeletal abnormalities across a broad age range from birth to late adulthood. PAH is usually severe and associated with bronchial and parenchymal abnormalities.
Molecular Interaction of Cytotoxic Anticancer Analogues as Inhibitors of β-tubulin Protein Against UACC-62 Melanoma Cell (2020)

Abstract Background In previous research, a series of cytotoxic anticancer analogues related to 2-acylamino-1,4-naphthoquinone derivatives has been demonstrated. As microtubule plays an important role in many essential cellular processes such as mitosis, tubulin is an important target of anticancer drug. Methods This study performed molecular docking simulation, pharmacophore model, comparative force field analysis model, and comparative similarity indices analysis model to investigate the relationship between inhibitory activities and the properties of compounds, in order to further progress the development of cytotoxic anticancer analogues. Results These compounds have common H-bond interactions with key residues Lys254 and Lys352, but compounds with large R 2 substituent have different docking poses than compounds with small R 2 substituent. Some of derivatives such as compound 18 formed the H-bonds with residue Lys254 using the oxygen atoms in R 1 substituent and formed π-cation interactions with residue Lys352 using phenyl moiety of 1,4-naphthoquinone. The R 1 substituent of these compounds preferred to have disfavored hydrophobic fields and favorable space toward the direction of residue Asn258, while the R 2 substituent of these compounds preferred to have about 2–3 carbon chain length hydrophobic substituent toward the direction of residues Ala316 and Lys352. Conclusion These results offer some beneficial advices for further study in anticancer drug development process.
Optical Components for Transport Network Enabling The Path to 6G (2021)

The evolution beyond 5G towards 6G will accelerate the transformations begun by 5G to deploy new approaches to define delivery services. The network should be accessible anywhere, always-on and with the guarantee performances. This poses new challenges to the transport network that should assure available connectivity among the functions at different levels of granularity. The transport network should be so flexible to guarantee on-demand the connectivity among the processing functions that automatically will be required and, at the same time, should assure extreme performance. Optical network and Dense Wavelength Division Multiplexing technology are relevant candidates to match high bandwidth and low latency, but new challenges are required to assure the suitable cost and size for the wireless access networks. The current optical technology, suitable used in aggregation and long-haul transport network, cannot be simply downsized to be used in the access area, but novel paradigm should be considered for the optics as well. Integrated photonics seems a promising direction to realize low cost and low size optical components for the transport network. Moreover, this technology enables a certain level of remote tunability and reconfiguration of optical equipment that allow to simplify and reduce cost of installation in field and operation of the transport network. In this paper relevant optical components for transport networks are analyzed using the integrated photonics to assess the technology challenges.
High-Precision Instrumentation for CO2 Isotope Ratio Measurements (2012)

Knowing atmospheric 13CO2/12CO2 ratios precisely is important in understanding biogenic and anthroprogenic sources and sinks for carbon. Currently available field deployable instrumentation has unfavorable attributes such as high power requirements, high cost and large size,. A high-precision isotopic measurement system is being developed that nullifies effects of pressure, temperature and moisture, and has characteristics suitable for field deployment. Early results find a precision of 0.4‰.
ChemInform Abstract: PHOSPHOTRIESTER SYNTHESIS OF DNA FRAGMENTS ON CELLULOSE AND POLYSTYRENE SOLID SUPPORTS (1982)

Abstract Die Synthese der 12 DNA‐Fragmente (IV)‐(XV) an polymeren Trägern (Cellulose oder Polystyrol) nach der Phosphotriester‐Methode wird beschrieben.
The Intersection of Environment and the Genome in Posttraumatic Stress Disorder (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
KSL/Logic: integration of logic with objects (2002)

KSL/Logic is an integration of logic and object-oriented programming that adds the declarative framework and deductive reasoning of logic programming to the powerful modeling capabilities of the object-oriented paradigm. Predicates, logic expressions, and the generalized search protocol of KSL/Logic are implemented as an integral part of KSL, a reflective, object-oriented programming language. KSL/Logic provides capabilities that go beyond those of Prolog to permit domain-based reasoning, functional arguments, matching of complex object patterns, and object representation of facts. The syntax and semantics of KSL/Logic are described, and the object implementation of its predicate resolution is examined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Infrared Temperature Measurements of the Blade Tip for a Turbine Operating at Corrected Engine Conditions (2020)

Abstract A high-speed infrared camera is used to measure the temperature of blade tips in a cooled high-pressure turbine operating at corrected engine conditions in The Ohio State University short duration Turbine Test Facility. These experiments create a challenging problem for infrared imaging since the rotor turns at over 13,000 rpm with tip speeds on the order of 300 m/s, and the surface temperature of the airfoils is on the order of 350 K. This means that the camera needs to capture a low intensity signal in a very short time period. This paper will review the design and operation of a measurement procedure to accomplish this difficult task along with the post-processing steps necessary to extract useful data. Raw infrared images are processed by deblurring the images using a non-blind Wiener filter and mapping the two-dimensional data onto the three-dimensional blade. This paper also describes experiments covering a range of cooling flow rates and main flow temperatures. In addition, several tests with no main flow and only cooling flow were performed at lower speeds to reduce motion blur and enable the separation of internal and external heat transfer information. Results show that the infrared data is consistent and can provide quantitative comparisons of cooling performance even at the high rotation speed. This paper presents the lessons learned for high-speed infrared measurement along with representative data to illustrate the repeatability and capability of the measurement scheme as well as suggested improvements to guide further development.
0414 Results From an On-Road Driving Performance Study In Non-elderly And Elderly Healthy Subjects with Dual Orexin Receptor Antagonist Lemborexant (2018)

Sedating CNS-active drugs are typically studied for the potential to impair next-morning driving. Data from an on-road driving performance study are presented for lemborexant (LEM), a dual orexin receptor antagonist under development for insomnia disorder. Randomized, double-blind, 4-period, incomplete crossover design. Healthy subjects (n=24 non-elderly, n=24 elderly; 26M, 22F) received placebo (P), zopiclone 7.5mg (Z; positive control), and 2 of 3 LEM doses (2.5/5/10mg). P and LEM were taken for 8 consecutive nights; Z was dosed on Night 1 and Night 8 with P on Nights 2–7. The standardized 1-hr on-road driving tests on Day 2 (D2) and Day 9 (D9) started ~9h post dose. Standard deviation of lateral position (SDLP in cm) was the primary endpoint. All 48 subjects completed the study. Assay sensitivity was demonstrated, as for Z vs P, the 95% CI upper bound was >2.4cm (standard threshold for impairment) at both D2 and D9. Additionally, mean SDLP for Z vs P and symmetry analyses of subjects with SDLP difference in Z vs P >2.4cm vs <2.4cm were statistically significant at D2 and D9 (P<0.01). For each LEM dose vs P, the 95% CI upper bound was <2.4cm. No mean SDLP for LEM vs P was significant for any dose on D2 (P>0.05) or D9 (P>0.05). Symmetry analyses were not statistically significant for any LEM dose on D2 or D9 (P>0.05). Results were similar in age and sex subgroups. No serious or severe adverse events (AEs) were reported. AEs of somnolence were reported more frequently after LEM 10mg than LEM 2.5 and 5mg administration. As measured by SDLP and at the doses tested, lemborexant did not impair driving performance after either single (Day 2) or multiple (Day 9) dose administration. These results warrant continued testing of the efficacy and safety of LEM for the treatment of insomnia disorder. Eisai, Inc and Purdue Pharma L.P.
Chromatographic and Spectroscopic Data of All Stereoisomers of Eudesm-11-en-4-ol (1992)

ABSTRACT Kovats indices and mass-, FTIR, 1-NMR- and 13C-NMR data were collected for all eight stereoisomers of eudesm-ll-en-4-ol, e.g. selin-ll-en-4α-ol, intermedeol, neointermedeol, paradisiol, amiteol. Differences in Kovats indices and mass spectral data of the various isomers are briefly discussed.
Preparation and optoelectronic properties of a novel poly(N‐vinylcarbazole) with covalently bonded titanium dioxide (2008)

Abstract A functional organic–inorganic composite containing carbazole moieties (electron donors) and TiO 2 (electron acceptors) in different molar ratios, TiO 2 ‐modified poly( N ‐vinylcarbazole) (PVK–TiO 2 ), was synthesized through a nucleophilic reaction. The molecular and electronic structure of the PVK–TiO 2 composite was characterized with Fourier transform infrared, ultraviolet–visible absorption, cyclic voltammetry, and so forth. The highest occupied molecular orbital and lowest unoccupied molecular orbital energy levels of the PVK–TiO 2 composite were higher than those of pristine poly( N ‐vinylcarbazole). The PVK–TiO 2 composite exhibited an enhanced glass‐transition temperature and improved thermal stability. The photoinduced charge transfer observed in photofluorescence and photoconductivity measurements makes applications in the field of photodetectors possible. The PVK–TiO 2 composite containing carbazole moieties and TiO 2 in a molar ratio of about 58 :1 was found to have the best photosensitivity. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Wireless Power Transmission from Space Solar Power Satellite/Station (SPS) (2009)

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The electrophysiologic basis for the antiarrhythmic and anticonvulsant effects of n−3 polyunsaturated fatty acids: Heart and brain (2001)

The n-3 polyunsaturated fatty acids (PUFA) have been shown to be antiarrhythmic in animals and probably in humans. PUFA stabilize the electrical activity of isolated cardiac myocytes by modulating sarcolemmal ion channels, so that a stronger electrical stimulus is required to elicit an action potential and the refractory period is markedly prolonged. Inhibition of voltage-dependent sodium currents, which initiate action potentials in excitable tissues, and of the L-type calcium currents, which initiate release of sarcoplasmic calcium stores, thus increasing cytosolic free calcium concentrations and activating the contractile proteins in myocytes, appears at present to be the probable major antiarrhythmic mechanisms of PUFA. Because the ion channels in neurons have channel proteins essentially homologous to those in the heart, the n-3 fatty acids would appear to be likely to affect the electrical activity in the brain in a manner similar to their effects in the heart, and accumulating evidence supports this notion. Evidence of important beneficial neurological effects of dietary n-3 PUFA are emerging with more likely to be discovered.
Mobilization of potent plasma bactericidal activity during systemic bacterial challenge. Role of group IIA phospholipase A2. (1998)

Extracellular mobilization of Group IIA 14-kD phospholipase A2 (PLA2) in glycogen-induced rabbit inflammatory peritoneal exudates is responsible for the potent bactericidal activity of the inflammatory fluid toward Staphylococcus aureus (1996. J. Clin. Invest. 97:250-257). Because similar levels of PLA2 are induced in plasma during systemic inflammation, we have tested whether this gives rise to plasma bactericidal activity not present in resting animals. Baboons were injected intravenously (i.v.) with a lethal dose of Escherichia coli and plasma or serum was collected before and at hourly intervals after injection. After infusion of bacteria, PLA2 levels in plasma and serum rose > 100-fold over 24 h to approximately 1 microg PLA2/ml. Serum collected at 24 h possessed potent bactericidal activity toward S. aureus, Streptococcus pyogenes, and encapsulated E. coli not exhibited by serum collected from unchallenged animals. Bactericidal activity toward S. aureus and S. pyogenes was nearly completely blocked by a monoclonal antibody to human Group IIA PLA2 and addition of purified human Group IIA PLA2 to prechallenge serum conferred potent antistaphylococcal and antistreptococcal activity equal to that of the 24 h post-challenge serum. PLA2-dependent bactericidal activity was enhanced approximately 10x by factor(s) present constitutively in serum or plasma. Bactericidal activity toward encapsulated E. coli was accompanied by extensive bacterial phospholipid degradation mediated, at least in part, by the mobilized Group IIA PLA2 but depended on the action of other bactericidal factors in the 24-h serum. These findings further demonstrate the contribution of Group IIA PLA2 to the antibacterial potency of biological fluids and suggest that mobilization of this enzyme during inflammation may play an important role in host defense against invading bacteria.
Lap-dissolve slides. Multiple-use formats for pre-laboratory instruction (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLap-dissolve slides. Multiple-use formats for pre-laboratory instructionLeonard W. Fine , David N. Harpp , Earl Krakower , and James P. Snyder Cite this: J. Chem. Educ. 1977, 54, 2, 72Publication Date (Print):February 1, 1977Publication History Received3 August 2009Published online1 February 1977Published inissue 1 February 1977https://doi.org/10.1021/ed054p72RIGHTS & PERMISSIONSArticle Views50Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Microwave bandstop filters with minimum through-line length (2015)

The theory of bandstop filters with minimum through-line length is developed in this paper. In contrast to conventional similar-resonator bandstop filters that employ odd multiples of 90-degree impedance inverters between resonators, the proposed design technique enables filters with through-line length restricted to only that which is required to obtain a desired coupling coefficient magnitude between a resonator and the through-line. Both even- and odd-order designs are shown to verify the concept. A 4 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> -order microstrip prototype with 45 degrees of through-line length per resonator was fabricated, measured, and compared to two conventional designs. It has half the through-line length of conventional designs.
Mapping the Binding Interface of VEGF and a Monoclonal Antibody Fab-1 Fragment with Fast Photochemical Oxidation of Proteins (FPOP) and Mass Spectrometry (2017)

We previously analyzed the Fab-1:VEGF (vascular endothelial growth factor) system described in this work, with both native top-down mass spectrometry and bottom-up mass spectrometry (carboxyl-group or GEE footprinting) techniques. This work continues bottom-up mass spectrometry analysis using a fast photochemical oxidation of proteins (FPOP) platform to map the solution binding interface of VEGF and a fragment antigen binding region of an antibody (Fab-1). In this study, we use FPOP to compare the changes in solvent accessibility by quantitating the extent of oxidative modification in the unbound versus bound states. Determining the changes in solvent accessibility enables the inference of the protein binding sites (epitope and paratopes) and a comparison to the previously published Fab-1:VEGF crystal structure, adding to the top-down and bottom-up data. Using this method, we investigated peptide-level and residue-level changes in solvent accessibility between the unbound proteins and bound complex. Mapping these data onto the Fab-1:VEGF crystal structure enabled successful characterization of both the binding region and regions of remote conformation changes. These data, coupled with our previous higher order structure (HOS) studies, demonstrate the value of a comprehensive toolbox of methods for identifying the putative epitopes and paratopes for biotherapeutic antibodies. Graphical abstract ᅟ.