gebhart/patrepeval huggingface dataset:
Techniques for Fabrication and Assembly of Rotors for Use in a Miniature Fast Analyzer (1973)

Abstract Several techniques are potentially useful for fabricating and assembling small, multicuvet, plastic rotors to be incorporated in a Miniature Fast Analyzer based on the GeMSAEC principle. Individual rotor components are machined or molded from acrylic plastic and assembled by heat sealing, gluing, or ultrasonic welding. The resulting rotors, which will ultimately be disposable, are useful in performing colorimetric biochemical analyses and are produced with a pathlength variation of only ±1%.
Glucocerebroside Alleviates Chronic Graft-Versus-Host-Disease in a Murine Model. (2004)

Abstract Background: Chronic graft-versus-host-disease (cGVHD) is a major obstacle to successful bone marrow transplantation. NKT lymphocytes may have a role in regulation of the immune attack in cGVHD. Glucocerebroside (GC) is a naturally occurring glycolipid that plays a role in the immune modulation of NKT lymphocytes. Objectives: To determine the immune modulatory effect of GC in a murine model of cGVHD. Methods: cGVHD was generated by infusion of 2x107 splenocytes from B10.D2 donor mice into Balb/c recipient mice, which received 7Gy 60Co total body irradiation (TBI) prior to transplantation. Recipient mice were followed for 55 days. Histological parameters of cGVHD-associated cutaneous, liver and bowel injury were assessed. To determine the mechanism of GC-mediated immune modulation, intrahepatic and intrasplenic lymphocytes were isolated and analyzed by FACS for CD4+, CD8+,CD56+ and NKT subpopulations. Serum cytokine levels were determined. Results: Treatment with GC significantly alleviated cGVHD. GC-treated mice gained weight and manifested a significant decrease in skin cGVHD clinical score (0.91 vs. 1.66 in GC treated vs. control mice, respectively). The beneficial effect of GC was associated with a 58% and a 31% reduction of the intrasplenic and the intrahepatic NKT cell number, respectively, accompanied by a 27% decrease of intrasplenic CD3+CD4+ T cells. Intrasplenic (but not intrahepatic) decrease in NK cell number was also observed in GC treated animals (48% vs. 7%). Administration of GC led to increased serum IFNγ and TNFa levels in GC treated compared to untreated controls (46 vs. 27, and 92 vs. 52 pg/ml, respectively), while IL10 levels decreased (61 vs. 83 pg/ml, respectively). Conclusions: Administration of GC led to significant amelioration of chronic GVHD. This effect was associated with an altered NKT lymphocyte distribution, decreased numbers of effector T lymphocytes and a shift towards a Th1-type cytokine profile. Glucocerebroside may serve as a new therapeutic measure for amelioration of cGVHD.
Small phospholipid-coated gas bubbles can last longer than larger ones (2008)

International audience
[Hyperparathyroidism and Hashimoto's thyroiditis: coincidence or consequence?]. (1990)

Primary hyperparathyroidism is commonly associated with Hashimoto's thyroiditis. The raised TSH levels might induce hyperparathyroidism, as suggested by some experimental data. It might also explain the development of hyperparathyroidism after neck irradiation and lithium therapy.
The Heegard-Berger problem with common receiver reconstructions (2013)

The variant of the Heegard-Berger problem where the receivers require identical reconstructions is studied, and the rate-distortion function for the following three settings is derived: (a) the encoder is also required to generate the reconstructions common to the receivers; (b) the side information at the receivers are physically degraded; and (c) the side information at the receivers are stochastically degraded, and the source satisfies a particular full-support condition. The characterizations indicate that the receiver side information can be fully exploited to perform Wyner-Ziv-style binning. However, the reconstruction functions can depend only on the randomness common to the receivers in the Gács-Körner sense.
Single Magnetic Bead Detection in a Microfluidic Chip Using Planar Hall Effect Sensor (2014)

In this study, we fabricate an integrated microfluidic chip with a planar Hall effect (PHE) sensor for single magnetic bead detection. The PHE sensor was constructed with a junction size of <TEX>$10{\mu}m{\times}10{\mu}m$</TEX> using a trilayer structure of Ta(3 nm)/NiFe(10 nm)/Cu(1.2 nm)/IrMn(10 nm)/Ta(3 nm). The sensitivity of the PHE sensor was 19.86 <TEX>${\mu}V/Oe$</TEX>. A diameter of 8.18 <TEX>${\mu}m$</TEX> magnetic beads was used, of which the saturation magnetization was ~2.1 emu/g. The magnetic susceptibility <TEX>${\chi}$</TEX> of these magnetic beads was calculated to be ~0.14. The diluted magnetic beads solution was introduced to the microfluidic channel attributing a single bead flow and simultaneously the PHE sensor voltage was measured to be 0.35 <TEX>${\mu}V$</TEX>. The integrated microchip was able to detect a magnetic moment of <TEX>$1.98{\times}10^{-10}$</TEX> emu.
Projection screen having reduced ambient light scattering (2023)

An apparatus and method for improving the contrast between incident projected light and ambient light reflected from a projection screen are described. The efficiency of the projection screen for reflection of the projected light remains high, while permitting the projection screen to be utilized in a brightly lighted room. Light power requirements from the projection system utilized may be reduced.
The Effect of Imatinib Mesylate on the Contractility of Isolated Rabbit Myometrial Strips (2006)

In isolated rabbit myometrium, acute inhibition of the c-kit receptor by imatinib mesylate affects only the amplitude of spontaneous contractions at concentrations, the equivalent of x10-100 the normal therapeutic concentration.
Anti-tumor efficacy in SIOPEL 6: A multi-centre open label randomised phase III trial of the efficacy of sodium thiosulphate (STS) in reducing ototoxicity in patients receiving cisplatin (Cis) monotherapy for standard risk hepatoblastoma (SR-HB). (2015)

10039 Background: SR-HB is defined as tumor extension limited to PRETEXT I, II or III, no portal, hepatic veins, or intra-abdominal extra-hepatic disease, AFP > 100ng/ml and no metastases. Cis can cause permanent bilateral high-frequency hearing loss. STS may reduce this risk, but could also reduce Cis anti-tumor efficacy. Methods: Newly diagnosed patients with SR-HB were treated with 2-weekly cycles of Cis, 4 before primary tumor resection and 2 after. Patients were randomized to Cis alone or Cis and STS. Cis 80mg/m2 was administered i.v. over 6 hrs. STS was administered i.v. exactly 6 hrs after stop of Cis over 15 minutes at 20g/m2. Response was assessed after 2 and 4 cycles pre-operative with serum AFP and liver imaging. In case of progression after 2 cycles, STS was stopped and doxorubicin 60mg/m2 continuous infusion over 48 hrs added. The primary endpoint is centrally reviewed absolute hearing threshold, at the age of ≥ 3.5 years, by pure tone audiometry. With a sample size of 102, the trial has 80% power to detect a reduction in hearing loss defined as Brock grade ≥ 1 from 60% of patients with Cis to 35% with Cis+STS. Short term anti-tumor efficacy endpoint is disease status at end of treatment which was evaluated after every 20 patients and submitted to the IDMC. Throughout the trial, the IDMC recommended continuation after interim review of efficacy results. Results: From 2007 to end 2014, 45 sites from 12 countries randomized 53 patients to Cis and 60 to Cis+STS, median age at diagnosis was 12.8 months. Treatment was well tolerated and acute toxicity similar between arms. Efficacy results after 4 pre-op chemo cycles for the first 94 patients (47 Cis, 47 Cis+STS) were PR/SD/PD for Cis: 86%/8%/6% and for Cis+STS: 90%/5%/5%. Complete remission after resection and post-op chemo was 92% and 98%. In January 2015, 2 pts had died (Cis arm), and 2 (Cis) and 1 (Cis+STS) had progressed. Conclusions: End of treatment anti-tumor efficacy in SR-HB treated on the above protocol shows no adverse outcome related to STS. Final evaluation of hearing loss at ≥ 3.5 yrs of age, the primary endpoint, is expected in 2017. Clinical trial information: NCT00652132.
Age-stratified distribution of metastatic sites in bladder cancer: A population-based analysis (2014)

We report a higher number of concomitant metastatic sites in young UCUB patients. Bone metastases are frequent in all patient groups, whereas brain metastases are common in UCUB patients with thoracic and/or bone metastases.
Recent trends in electrochemical nanobiosensors for environmental analysis (2015)

In recent years, there has been a huge need for fast and reliable methods for environmental monitoring. Conventional analytical techniques for environmental pollutants entail high cost, trained personnel and often are not available for in situ detection. Conversely, electrochemical nanobiosensors have the advantages of low cost, ease of use, portability and ability to perform both screening and real-time monitoring of the area under investigation. This paper presents a review of the use of electrochemical nanobiosensors for the analysis of environmental pollutants, taking into particular account the general principles and characteristics as well as some representative applications of protein, antibody and aptamer-based biosensors.
Self-consistent calculation of metamaterials with gain (2009)

We present a computational scheme allowing for a self-consistent treatment of a dispersive metallic photonic metamaterial coupled to a gain material incorporated into the nanostructure. The gain is described by a generic four-level system. A critical pumping rate exists for compensating the loss of the metamaterial. Nonlinearities arise due to gain depletion beyond a certain critical strength of a test field. Transmission, reflection, and absorption data as well as the retrieved effective parameters are presented for a lattice of resonant square cylinders embedded in layers of gain material and split ring resonators with gain material embedded into the gaps.
An advanced photovoltaic array regulator module (2002)

Current trends in satellite design are focused on developing small, reliable, and inexpensive spacecraft. To that end, a modular power management and distribution system is proposed which will help transition the aerospace industry towards an assembly line approach to building spacecraft. The modular system is based on an innovative DC voltage boost converter called the series connected boost unit (SCBU). The SCBU uses any isolating DC-DC power converter and adds a unique series connection. This simple modification provides the SCBU topology with many advantages over existing boost power converters. Efficiencies of 94-98%, power densities above 1,000 W/kg and inherent fault tolerance are just a few of the characteristics presented. Limitations of the SCBU technology are presented and it is shown that the SCBU makes an ideal photovoltaic array regulator. A set of photovoltaic power system requirements are presented that can be applied to almost any low Earth orbit satellite. Finally, a modular design based on the series connected boost unit is outlined and functional descriptions of the components are given.
Paradoxical Abatement of Striatal Dopaminergic Transmission by Cocaine and Methylphenidate (2013)

We combined in vitro amperometric, optical analysis of fluorescent false neurotransmitters and microdialysis techniques to unveil that cocaine and methylphenidate induced a marked depression of the synaptic release of dopamine (DA) in mouse striatum. In contrast to the classical dopamine transporter (DAT)-dependent enhancement of the dopaminergic signal observed at concentrations of cocaine lower than 3 μM, the inhibitory effect of cocaine was found at concentrations higher than 3 μM. The paradoxical inhibitory effect of cocaine and methylphenidate was associated with a decrease in synapsin phosphorylation. Interestingly, a cocaine-induced depression of DA release was only present in cocaine-insensitive animals (DAT-CI). Similar effects of cocaine were produced by methylphenidate in both wild-type and DAT-CI mice. On the other hand, nomifensine only enhanced the dopaminergic signal either in wild-type or in DAT-CI mice. Overall, these results indicate that cocaine and methylphenidate can increase or decrease DA neurotransmission by blocking reuptake and reducing the exocytotic release, respectively. The biphasic reshaping of DA neurotransmission could contribute to different behavioral effects of psychostimulants, including the calming ones, in attention deficit hyperactivity disorder.
Self-calibration of metrics of Java methods (2002)

Self-calibration is a new technique for the study of internal product metrics, sometimes called "observations" and calibrating these against their frequency, or probability of occurring in common programming practice (CPP). Data gathering and analysis of the distribution of observations is an important prerequisite for predicting external qualities, and in particular software complexity. The main virtue of our technique is that it eliminates the use of absolute values in decision-making, and allows gauging local values in comparison with a scale computed from a standard and global database. Method profiles are introduced as a visual means to compare individual projects or categories of methods against the CPP. Although the techniques are general and could in principle be applied to traditional programming languages, the focus of the paper is on object oriented languages using Java. The techniques are employed in a suite of 17 metrics in a body of circa thirty thousand Java methods.
Restoration of lossy compressed noisy images (1999)

Noise degrades the performance of any image compression algorithm. However, at very low bit rates, image coders effectively filter noise that may he present in the image, thus, enabling the coder to operate closer to the noise free case. Unfortunately, at these low bit rates the quality of the compressed image is reduced and very distinctive coding artifacts occur. This paper proposes a combined restoration of the compressed image from both the artifacts introduced by the coder along with the additive noise. The proposed approach is applied to images corrupted by data-dependent Poisson noise and to images corrupted by film-grain noise when compressed using a block transform-coder such as JPEG. This approach has proved to be effective in terms of visual quality and peak signal-to-noise ratio (PSNR) when tested on simulated and real images.
Silylene Complexes of Late 3d Transition Metals Supported by tris-Phosphinoborate Ligands (2018)

The complexes [BP3R]MX ([BP3R] = PhB(CH2PR2)3–, R = Ph, iPr; M = Ni, Co, Fe; X = halide) were explored as platforms for generation of first-row metal silylene complexes. Direct silylation of [BP3Ph]NiCl or [BP3iPr]CoCl with (THF)2LiSiHMes2 resulted in formation of the silylene complexes [BP3Ph]Ni(μ-H)(SiMes2) and [BP3iPr]Co(μ-H)(SiMes2), respectively. In contrast, [BP3iPr]FeBr reacted with (THF)2LiSiHMes2 to produce the iron-alkyl [BP3iPr]Fe(CH2-2-(SiH2Mes)-3,5-Me2C6H2), a constitutional isomer of the expected silyl or silylene complex. Preparation of the nickel benzyl complex [BP3Ph]Ni(η2-Bn) allowed for exploration of addition–elimination chemistry for access to silylene complexes from simple primary and secondary silanes. Heating toluene solutions of [BP3Ph]Ni(η2-Bn) in the presence of CySiH3 resulted in the formation of a dimeric μ-silylene complex [Ni(μ-BP2Ph)(μ-SiHCy)]2. In the presence of 4-dimethylaminopyridine (DMAP), these conditions led to exclusive formation of the base-stabilized silylene complex [BP3Ph]Ni(μ-H)[SiHCy(DMAP)].
Thermal history of the Denver Basin [open quotes]hot spot[close quotes] (1996)

The Denver Basin Hot Spot is an area of anomalous thermal maturity within the Denver Basin. It is located on the basin axis north of Denver, and it is also on the northeast extension of the trend defined by the plutons of the Colorado Mineral Belt into the Denver Basin. While deep burial is thought to have formed at least some of the thermal maturation within the Hot Spot, deep burial can not explain the occurrence of the highest levels of thermal maturation (VRo [approximately] 1.50%) nor the present high geothermal gradients (35[degrees]C/km - 50[degrees]C/km). An additional source of heat is necessary to produce these anomalous levels of thermal maturation. Apatite fission-track ages on apatite and zircon separated from Cretaceous bentonites, previously published K/Ar ages of illite/smectite (I/S) and vitrinite reflectance measurements together indicate that secondary heating events occurred at different times at different places within the Hot Spot. At Lyons, CO, the narrow apatite fission-track length distribution and the concordance of the apatite fission track ages with the K/Ar ages of I/S indicate this area of the Hot Spot was heated by Early Tertiary plutons as well as burial. The highest vitrinite values (VRo [approximately] 1.50%) measured from themore » Muddy J Sandstone are associated with the present geothermal gradients, and are thought to have formed by secondary heating within the past 20 m.y. ago. The thermal history of the Hot Spot is complex, and the processes responsible for the anomalous thermal maturity are elucidated by combined use of fission track, K/Ar and vitrinite reflectance measurements.« less
Population Pharmacokinetics of Danofloxacin in Yellow River Carp (Cyprinus carpio haematopterus) After One Single Oral Dose (2022)

This study aimed to determine the population pharmacokinetics of danofloxacin in healthy Yellow River carp (<i>Cyprinus carpio Haematopterus</i>) after single oral administration at 10 mg/kg body weight (BW). A sparse sampling was applied in this study and plasma samples were randomly collected from the tail veins of six carp at 0.25, 0.5, 1, 2, 4, 6, 8, 12, 16, 24, 36, 48, 72, 96, 120 and 144 h after administration. A maximum of four plasma samples was collected from each carp. Then the concentrations of danofloxacin in plasma samples were determined through an HPLC method. Danofloxacin could be quantified in plasma up to 144 h after administration. The corresponding population pharmacokinetic modeling was developed according to the non-linear mixed effect method, including covariate and covariance models to explain some variations from unknown sources and improve the prediction ability. On the premise of sparse sampling, the typical values of the population (fixed effect) and inter-individual variation (random effect) were described by the current population pharmacokinetic model. The estimated typical values and coefficient of variation between individuals (CV%) of absorption rate constant (tvKa), apparent distribution volume (tvV) and clearance (tvCL) were 2.48 h<sup>-1</sup> and 0.203%, 47.8 L/kg and 8.40%, 0.694 L/h/kg and 4.35%, respectively. The current danofloxacin oral dosing (10 mg/kg BW) can provide suitable plasma concentrations to inhibit those pathogens with MIC values below 0.016 μg/ml based on the calculated PK/PD indices of AUC/MIC or C<sub>max</sub>/MIC. Further studies are still needed to determine the <i>in vitro</i> and <i>in vivo</i> antibacterial efficacy of danofloxacin against pathogens isolated from Yellow River carp and finally draw a reasonable dosing regimen.
The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes (2021)

H-ficolin recognizes patterns on microorganisms and stressed cells and can activate the lectin pathway of the complement system. We aimed to assess H-ficolin in relation to the progression of diabetic kidney disease (DKD), all-cause mortality, diabetes-related mortality, and cardiovascular events. Event rates per 10-unit H-ficolin-increase were compared in an observational follow-up of 2,410 individuals with type 1 diabetes from the FinnDiane Study. DKD progression occurred in 400 individuals. The unadjusted hazard ratio (HR) for progression was 1.29 (1.18-1.40) and 1.16 (1.05-1.29) after adjustment for diabetes duration, sex, HbA<sub>1c</sub>, systolic blood pressure, and smoking status. After adding triglycerides to the model, the HR decreased to 1.07 (0.97-1.18). In all, 486 individuals died, including 268 deaths of cardiovascular causes and 192 deaths of complications to diabetes. HRs for all-cause mortality and cardiovascular mortality were 1.13 (1.04-1.22) and 1.05 (0.93-1.17), respectively, in unadjusted analyses. These estimates lost statistical significance in adjusted models. However, the unadjusted HR for diabetes-related mortality was 1.19 (1.05-1.35) and 1.18 (1.02-1.37) with the most stringent adjustment level. Our results, therefore, indicate that H-ficolin predicts diabetes-related mortality, but neither all-cause mortality nor fatal/non-fatal cardiovascular events. Furthermore, H-ficolin is associated with DKD progression, however, not independently of the fully adjusted model.
Evaluation of Baiting Techniques for Sampling Wireworms (Coleoptera: Elateridae) Infesting Wheat in Washington1 (1983)

Journal Article Evaluation of Baiting Techniques for Sampling Wireworms (Coleoptera: Elateridae) Infesting Wheat in Washington Get access Harold H. Toba, Harold H. Toba Yakima Agricultural Research Laboratory, U.S. Department of Agriculture, Agriculture Research Service, Yakima, Washington 98902 Search for other works by this author on: Oxford Academic PubMed Google Scholar John E. Turner John E. Turner Yakima Agricultural Research Laboratory, U.S. Department of Agriculture, Agriculture Research Service, Yakima, Washington 98902 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 76, Issue 4, 1 August 1983, Pages 850–855, https://doi.org/10.1093/jee/76.4.850 Published: 01 August 1983 Article history Received: 23 August 1982 Accepted: 15 February 1983 Published: 01 August 1983
Thiopurines Are Associated with a Reduction in Surgical Re-resections in Patients with Crohnʼs Disease (2013)

Thiopurines are effective in preventing surgical recurrence of CD. The role of anti-TNF-α antibodies seems promising as well. Combination therapy of thiopurines and anti-TNF-α antibodies for prevention of surgical recurrence of CD should be studied in a randomized trial.
The IGEX experiment reexamined: A response to the critique of Klapdor-Kleingrothaus, Dietz, and Krivosheina (2004)

This paper is a response to the preceding Comment by Klapdor-Kleingrothaus, Dietz, and Krivosheina. The criticisms are confronted, and the questions raised are answered. We demonstrate that the lower limit quoted by IGEX, , is correct and that there was no ``arithmetical error'' as claimed in the ``Critical View'' article.
UFF Spotting Technique for Studying Polishing Process Conditions for Optical Glasses and Ceramics (2010)

We report on the use of UltraForm Finishing spot taking technique to study the surface interactions and process parameters with a variety of polishing pads. The work extends from relatively soft glasses to hard ceramics.