gebhart/patrepeval huggingface dataset:
<title>200/300-mm Micrascan IV 248-nm system for high-throughput and tight CD control applications</title> (2000)

Micrascan (MS) IV is designed to provide superior Critical Dimension (CD) control &amp; overlay performance at very high wafer throughputs for both 200 and 300mm wafers at low cost of ownership. This new system, targeted for sub-critical applications, includes SVGL's new flexible cross-performance platform and improved 0.6NA Catadioptric Projection Optics for better resolution and overlay. A new Laser Illumination System (LIS), capable of high doses at high throughput, uses a 2 kHz semi line narrowed KrF laser. SVGL has demonstrated its MS IV 248nm DUV optical design for successful insertion at the 180nm Lithography node. In this paper, modeled capabilities of SVGL's DUV optical design for both group and isolated lines will be presented. The performance potential with both conventional and enhanced illumination will be considered. Data from SVGL's Micrascan systems, illustrating Linewidth control, Depth Of Focus (DOF) performance for 180nm Group and Isolated Features, and overlay performance potential will be given. The Cross performance platform wiht its high throughput capabilities will be discussed.
The Indian Consensus Document on cardiac biomarker (2014)

Despite recent advances, the diagnosis and management of heart failure evades the clinicians. The etiology of congestive heart failure (CHF) in the Indian scenario comprises of coronary artery disease, diabetes mellitus and hypertension. With better insights into the pathophysiology of CHF, biomarkers have evolved rapidly and received diagnostic and prognostic value. In CHF biomarkers prove as measures of the extent of pathophysiological derangement; examples include biomarkers of myocyte necrosis, myocardial remodeling, neurohormonal activation, etc. In CHF biomarkers act as indicators for the presence, degree of severity and prognosis of the disease, they may be employed in combination with the present conventional clinical assessments. These make the biomarkers feasible options against the present expensive measurements and may provide clinical benefits.
Development of Surgical Tools and Procedures for Experimental Preclinical Surgery Using Computer Simulations And 3D Printing (2020)

Abstract—Experimental preclinical surgeries require high accuracy and repeatability in all applied procedures. For in vivo studies investigating bone fracture healing it is crucial to create precisely and consistently the experimental bone fractures in all included subjects. In large animal models the required precision is usually achieved by application of dedicated drilling jigs and cutting guides that often need to be individually designed in order to fulfil the requirements of a particular experiment. Moreover, their final design may considerably differ from the prototypes. Hence, the designing and testing processes require multiple iterative refinement loops substantially increasing the costs of the experiment. Therefore, a framework for development of tailor-made instruments for experimental preclinical surgeries is established to reduce the investment of time and financial effort.
Tricuspid Valve Repair for the Poor Right Ventricle: Tricuspid Valve Repair in Patients with Mild-to-Moderate Tricuspid Regurgitation Undergoing Mitral Valve Repair Improves In-Hospital Outcome (2015)

<b>Background</b> Tricuspid regurgitation (TR) in patients undergoing surgery for mitral valve (MV) increases morbidity and mortality, especially in case of a poor right ventricle. Does repair of mild-to-moderate insufficiency of the tricuspid valve (TV) in patients undergoing MV surgery lead to a benefit in early postoperative outcome? <b>Methods</b> A total of 22 patients with mild-to-moderate TR underwent MV repair and concomitant TV repair with Tri-Ad (Medtronic ATS Medical Inc., Minneapolis, Minnesota, United States) and Edwards Cosgrove (Edwards Lifesciences Irvine, California, United States) rings. The severity of TR was assessed echocardiographically by using color-Doppler flow images. The tricuspid annular plane systolic excursion (TAPSE) was under 1.7 cm. Additional procedures included coronary artery bypass (<i>n</i> = 9) and maze procedure (<i>n</i> = 15). The following parameters were compared: postoperative and peak dose of noradrenaline (NA), pre/postoperative systolic pulmonary pressure (sPAP), extubation time, operation time, cross-clamp time, cardiopulmonary bypass (CPB) time, pre/postoperative ejection fraction (EF), intensive care unit (ICU)-stay, hospital stay, cell saver blood transfusion, intra/postoperative blood transfusion, and postoperative TR. <b>Results</b> The mean age was 67 ± 14.8 years, 45% were male. Mean EF was 47 ± 16.2%, postoperative 52 ± 12.4%. sPAP was 46 ± 20.1 mm Hg preoperatively, sPAP was 40.6 ± 9.4 mm Hg postoperatively, NA postoperatively was 12 ± 10 μg/min, NA peak was 18 ± 11 μg/min, operation time was 275 ± 92 minutes, CPB was 145 ± 49 minutes, ICU stay was 2.4 ± 2.4 days, hospital stay was 10.8 ± 3.5 days, cell saver blood transfusion was 736 ± 346 mL, intraoperative transfusions were 2.5 ± 1.6. Two patients needed postoperative transfusions. A total of 19 patients were extubated at the 1st postoperative day, 2 patients at the 2nd day, and 1 at the 4th postoperative day. Two patients required a pacemaker. No reintubation, no in-hospital mortality, and one reoperation because of bleeding complications. <b>Conclusion</b> Correction of mild-to-moderate TR at the time of MV repair does maintain TV function and avoid right ventricular dysfunction in the early postoperative period improving the clinical outcome.
Conversion of an Injectable MMP-Degradable Hydrogel into Core-Cross-Linked Micelles (2020)

In this study, a new type of injectable hydrogel called "HyMic" that can convert into core cross-linked (CCL) micelles upon exposure to matrix metalloproteinases (MMP's), was designed and developed for drug delivery applications. HyMic is composed of CCL micelles connected via an enzyme cleavable linker. To this end, two complementary ABA block copolymers with polyethylene glycol (PEG) as B block were synthesized using atom transfer radical polymerization (ATRP). The A blocks were composed of a random copolymer of <i>N</i>-isopropylacrylamide (NIPAM) and either <i>N</i>-(2-hydroxypropyl)methacrylamide-cysteine (HPMA-Cys) or <i>N</i>-(2-hydroxypropyl) methacrylamide-ethylthioglycolate succinic acid (HPMA-ETSA). Mixing the aqueous solutions of the obtained polymers and rising the temperature above the cloud point of the PNIPAM block resulted in the self-assembly of these polymers into flower-like micelles composed of a hydrophilic PEG shell and hydrophobic core. The micellar core was cross-linked by native chemical ligation between the cysteine (in HPMA-Cys) and thioester (in HPMA-ETSA) functionalities. A slight excess of thioester to cysteine groups (molar ratio 3:2) was used to allow further chemical reactions exploiting the unreacted thioester groups. The obtained micelles displayed a <i>Z</i>-average diameter of 80 ± 1 nm (PDI 0.1), and ζ-potential of -4.2 ± 0.4 mV and were linked using two types of pentablock copolymers of P(NIPAM-<i>co</i>-HPMA-Cys)-PEG-peptide-PEG-P(NIPAM-<i>co</i>-HPMA-Cys) (Pep-NC) to yield hydrogels. The pentablock copolymers were synthesized using a PEG-peptide-PEG ATRP macroinitiator and the peptide midblock (lysine-glycine-proline-glutamine-isoleucine-phenylalanine-glycine-glutamine-lysine (Lys-Gly-Pro-Gln-Gly-Ile-Phe-Gly-Gln-Lys)) consisted of either l- or d-amino acids (l-Pep-NC or d-Pep-NC), of which the l-amino acid sequence is a substrate for matrix metalloproteases 2 and 9 (MMPs 2 and 9). Upon mixing of the CCL micelles and the linker (l/d-Pep-NC), the cysteine functionalities of the l/d-Pep-NC reacted with remaining thioester moieties in the micellar core via native chemical ligation yielding a hydrogel within 160 min as demonstrated by rheological measurements. As anticipated, the gel cross-linked with l-Pep-NC was degraded in 7-45 days upon exposure to metalloproteases in a concentration-dependent manner, while the gel cross-linked with the d-Pep-NC remained intact even after 2 months. Dynamic light scattering analysis of the release medium revealed the presence of nanoparticles with a <i>Z</i>-average diameter of ∼120 nm (PDI < 0.3) and ζ-potential of ∼-3 mV, indicating release of core cross-linked micelles upon HyMic exposure to metalloproteases. An in vitro study demonstrated that the released CCL micelles were taken up by HeLa cells. Therefore, HyMic as an injectable and enzyme degradable hydrogel displaying controlled and on-demand release of CCL micelles has potential for intracellular drug delivery in tissues with upregulation of MMPs, for example, in cancer tissues.
Modifiable risk factors associated with cardiovascular disease and mortality in China: a PURE substudy (2022)

Both CVD and mortality are higher in men compared with women, and in rural compared with urban areas. Large reductions in CVD could potentially be achieved by controlling metabolic risk factors and improving education. Lowering mortality rates will require strategies addressing a broader range of risk factors.
Supplemental Figure S6 from Reduction of MDSCs with All-trans Retinoic Acid Improves CAR Therapy Efficacy for Sarcomas (2023)

&lt;p&gt;ATRA treatment does not induce FOXP3 expression in GD2-CAR T cells in NSG mice.&lt;/p&gt;
Periplasmic maltose- and glucose-binding protein activities in cell-free extracts of Thermotoga maritima (2002)

In this study, high-affinity maltose- and glucose-binding activities in cell-free extracts of Thermotoga maritima were detected; these activities were distinct and specific. At the gross level, the expression of binding-protein activities was repressed by growth of T. maritima in the presence of the cognate sugar. Growth of the organism in the presence of maltose reduced maltose-binding activity but not glucose-binding activity, while growth in the presence of glucose reduced glucose-binding activity but not maltose-binding activity. In competition assays, these binding activities showed distinct patterns of substrate specificity: whereas the maltose-binding activity showed specificity for alpha-linked glucosides, the glucose-binding activity showed a broader specificity. All maltose- and glucose-binding activity was found in the supernatant retrieved following centrifugation (100,000 g) of the cell-free extracts prepared by French-pressure-cell treatment; no activity was found in an octyl-glucoside-treated extract of the membrane fraction. The maltose-binding-protein activity was recovered from the periplasmic fraction by selective release of the periplasmic contents of T. maritima cells using a newly developed freeze-thaw procedure. Annotation of the complete genome sequence of T. maritima suggests that there may be at least two maltose-binding proteins, MalE1 and MalE2, encoded in the genome. The maltose-binding activity corresponded to a protein of 43 kDa, which was consistent in size with either of the putative proteins. These data demonstrate that the hyperthermophilic bacterium T. maritima possesses separate maltose- and glucose-binding-protein activities that are freely soluble in its periplasm, in contrast to the membrane-bound sugar-binding proteins found in archaeal hyperthermophiles.
Fast custom instruction identification by convex subgraph enumeration (2008)

Automatic generation of custom instruction processors from high-level application descriptions enables fast design space exploration, while offering very favorable performance and silicon area combinations. This work introduces a novel method for adapting the instruction set to match an application captured in a high-level language. A simplified model is used to find the optimal instructions via enumeration of maximal convex subgraphs of application data flow graphs (DFGs). Our experiments involving a set of multimedia and cryptography benchmarks show that an order of magnitude performance improvement can be achieved using only a limited amount of hardware resources. In most cases, our algorithm takes less than a second to execute.
Apolipoprotein EBethesda: A New Variant of Apolipoprotein E Associated with Type III Hyperlipoproteinemia (1983)

Apolipoprotein E (apoE) is associated with plasma lipoproteins and is important in modulating the catabolism of remnants of triglyceride-rich lipoproteins. ApoE is a polymorphic protein, and homozygosity for the E2 allele is associated with type III hyperlipoproteinemia. A variant of apoE, apoEBethesda, was found that migrates in the E1 position on isoelectric focusing. Evaluation of the proband and her family showed that both individuals with apoEBethesda had type III hyperlipoproteinemia, and the analysis was consistent with the concept that apoEBethesda was coded by a new E allele and that this allele was expressed in a codominant fashion. The discovery of apoEBethesda and its association with type III hyperlipoproteinemia provides additional evidence for the genetic heterogeneity of the E allele and suggests that a number of different structural mutations of the E apolipoprotein may be associated with the type III phenotype.
Effects of Bordetella bronchiseptica dermonecrotic toxin on the structure and function of osteoblastic clone MC3T3-e1 cells (1991)

The effects of Bordetella bronchiseptica dermonecrotic toxin on the structure and function of a clonal osteoblastic cell line, MC3T3-E1, were investigated. The toxin induced a morphological change in the cells from a spindle shape to a spherical form with many blebs. The toxin-treated cells were viable and grew to form confluent cell layers composed of irregularly shaped cells and multinuclear cells. The toxin inhibited elevation of alkaline phosphatase activity in the cells in a dose-dependent manner at concentrations from 10 pg to 10 ng/ml. The accumulation of type I collagen in the cells was also reduced by the toxin. Since high alkaline phosphatase activity and accumulation of collagen are closely linked to differentiation of the cells into osteoblasts, it is considered likely that B. bronchiseptica dermonecrotic toxin impairs the ability of the cells to differentiate.
Answering tree pattern queries using views (2006)

We study the query answering using views (QAV) problem for tree pattern queries. Given a query and a view, the QAV problem is traditionally formulated in two ways: (i) find an equivalent rewriting of the query using only the view, or (ii) find a maximal contained rewriting using only the view. The former is appropriate for classical query optimization and was recently studied by Xu and Ozsoyoglu for tree pattern queries (TP). However, for information integration, we cannot rely on equivalent rewriting and must instead use maximal contained rewriting as shown by Halevy. Motivated by this, we study maximal contained rewriting for TP, a core subset of XPath, both in the absence and presence of a schema. In the absence of a schema, we show there are queries whose maximal contained rewriting (MCR) can only be expressed as the union of exponentially many TPs. We characterize the existence of a maximal contained rewriting and give a polynomial time algorithm for testing the existence of an MCR. We also give an algorithm for generating the MCR when one exists. We then consider QAV in the presence of a schema. We characterize the existence of a maximal contained rewriting when the schema contains no recursion or union types, and show that it consists of at most one TP. We give an efficient polynomial time algorithm for generating the maximal contained rewriting whenever it exists. Finally, we discuss QAV in the presence of recursive schemas.
Carbamylation Decreases the Cytotoxicity but not the Drug-Carrier Properties of Polylysines (1995)

The charge density of Poly(D-lysine) was reduced by the carbamylation of the lysyl residues with potassium cyanate. A decrease in the charge density of poly(D-lysine) by 25% and 50% reduced the cytotoxicity of the ligand to cultured L929 cells by a 5-, and a 20 to 25-fold level, respectively, as estimated by using either the viability or the protein assay. The uptake of cyanate-modified poly(D-lysine) ligands in cultured L929 cells was not reduced, while the uptake of poly(D-lysine)/Heparin complex was reduced by 80%, as compared to that of unmodified poly(D-lysine). The in vivo biodistribution of cyanate-modified poly(D-lysine) ligands in the lungs and the liver of mice was not altered in comparison to that of unmodified poly(D-lysine), whereas the poly(D-lysine)/Heparin complex was only accumulated in the liver but not in the lungs. The data in this paper indicate that a 50% decrease in the positive charge density of poly(D-lysine) reduces the toxicity, but not the carrier potential of this polycationic ligand.
Pose Estimation by Combining IMU Sensor and Vision Sensor (2014)

Augmented reality technique is a hot topic in computer vision, and AR has been widely used in mobile applications, medical domain, education, military, etc. But AR has illumination problem, when vision sensor has long range movements or heavily movements, vision sensor would be not detect AR marker. So we propose pose estimation technique by combining IMU sensor and vision sensor. IMU sensor is added on vision sensor, and estimate pose of vision sensor. Whether IMU sensor can accurately estimate camera pose lonely is our main challenge.
Constants across cultures in the face and emotion. (1971)

This study addresses the question of whether any facial expressions of emotion are universal. Recent studies showing that members of literate cultures associated the same emotion concepts with the same facial behaviors could not demonstrate that at least some facial expressions of emotion are universal; the cultures compared had all been exposed to some of the same mass media presentations of facial expression, and these may have taught the people in each culture to recognize the unique facial expressions of other cultures. To show that members of a preliterate culture who had minimal exposure to literate cultures would associate the same emotion concepts with the same facial behaviors as do members of Western and Eastern literate cultures, data were gathered in New Guinea by telling subjects a story, showing them a set of three faces, and asking them to select the face which showed the emotion appropriate to the story. The results provide evidence in support of the hypothesis that the association between particular facial muscular patterns and discrete emotions is universal.
Approximation de l'enveloppe convexe de l'attracteur d'un IFS affine (2012)

International audience
Testing of a long-term fall detection system incorporated into a custom vest for the elderly (2008)

A fall detection system and algorithm, incorporated into a custom designed garment has been developed. The developed fall detection system uses a tri-axial accelerometer to detect impacts and monitor posture. This sensor is attached to a custom designed vest, designed to be worn by the elderly person under clothing. The fall detection algorithm was developed and incorporates both impact and posture detection capability. The vest and fall algorithm was tested by two teams of 5 elderly subjects who wore the sensor system in turn for 2 week each and were monitored for 8 hours a day. The system previously achieved sensitivity of >90% and a specificity of >99%, using young healthy subjects performing falls and normal activities of daily living (ADL). In this study, over 833 hours of monitoring was performed over the course of the four weeks from the elderly subjects, during normal daily activity. In this time no actual falls were recorded, however the system registered a total of the 42 fall-alerts however only 9 were received at the care taker site. A fall detection system incorporated into a custom designed garment has been developed which will help reduce the incidence of the long-lie, when falls occur in the elderly population. However further development is required to reduce the number of false-positives and improve the transmission of messages.
Cytochrome c Maturation and the Physiological Role of c -Type Cytochromes in Vibrio cholerae (2005)

Vibrio cholerae lives in different habitats, varying from aquatic ecosystems to the human intestinal tract. The organism has acquired a set of electron transport pathways for aerobic and anaerobic respiration that enable adaptation to the various environmental conditions. We have inactivated the V. cholerae ccmE gene, which is required for cytochrome c biogenesis. The resulting strain is deficient of all c-type cytochromes and allows us to characterize the physiological role of these proteins. Under aerobic conditions in rich medium, V. cholerae produces at least six c-type cytochromes, none of which is required for growth. Wild-type V. cholerae produces active fumarate reductase, trimethylamine N-oxide reductase, cbb3 oxidase, and nitrate reductase, of which only the fumarate reductase does not require maturation of c-type cytochromes. The reduction of nitrate in the medium resulted in the accumulation of nitrite, which is toxic for the cells. This suggests that V. cholerae is able to scavenge nitrate from the environment only in the presence of other nitrite-reducing organisms. The phenotypes of cytochrome c-deficient V. cholerae were used in a transposon mutagenesis screening to search for additional genes required for cytochrome c maturation. Over 55,000 mutants were analyzed for nitrate reductase and cbb3 oxidase activity. No transposon insertions other than those within the ccm genes for cytochrome c maturation and the dsbD gene, which encodes a disulphide bond reductase, were found. In addition, the role of a novel CcdA-like protein in cbb3 oxidase assembly is discussed.
Structural changes and cell properties of human ovarian surface epithelium in ovarian pathophysiology (2006)

The surface epithelial cells of the ovary, which are modified peritoneal cells, form a single, focally pseudostratified layer. The Müllerian ducts differentiate after invagination of the coelomic mesothelium over the gonadal ridges during the 6th week of embryonic life. On the basis of the embryologically putative Müllerian potential of this epithelium, endometriosis can be explained by coelomic metaplasia from the peritoneum, including ovarian surface epithelium. Some pelvic endometriosis specimens have shown that epithelial cells on the ovary or pelvis are serially changed to endometriotic gland cells. Immunohistochemistry as well as scanning electron microscopy also reinforce the light-microscopical findings. A three-dimensional culture system demonstrated that human ovarian surface epithelial cells exhibited a glandular-stromal structure when they were cocultured with endometrial stromal cells in an estrogen-rich environment. Ovarian carcinomas in the epithelial-stromal category are thought to arise from the surface epithelium and its inclusions. The ovarian surface epithelium is physiologically involved in follicular rupture, oocyte release, and the subsequent repair of follicle wall during reproductive age. Simultaneously, ovulation may cause a loss of integrity of the surface epithelium, followed by accumulation of multiple mutations. The cortical invagination, surface stromal proliferation, and Müllerian differentiation of these cells are likely not to be an early step in the cancer development. However, the inclusion cysts are closely related with carcinogenesis because they are significantly more common in ovaries contralateral to those containing epithelial cancers than in control ovaries. As an in vitro study, ovarian carcinoma cell lines were established from simian virus 40 large T antigen-transformed human surface epithelial cells of the ovary. Further investigations of these cell lines may lead to insights into the preneoplastic and early stages of carcinomas. To clarify the pathogenesis of endometriosis and epithelial ovarian cancer, specifically designed studies of ovarian surface epithelium are required.