gebhart/patrepeval huggingface dataset:
P01.06 Function of ecotropic viral integration site 1 (EVI1) gene in human glioma cells (2016)

INTRODUCTION: Ecotropic viral integration site 1 (EVI1) gene encodes a transcription factor, containing ten zinc finger motifs found within two domains of the protein. Abnormal expression of EVI1 is found in 5–10% of patients with acute myeloid leukemia (AML), and is associated with unfavorable outcome. High expression of EVI1 is also associated with poor outcome of patients with glioblastoma and ependymoma. EVI1 maintains the self-renewal capacity of hematopoietic stem cells (HSCs), of cell quiescence and stem cell-like phenotypes in leukemia cells. Analysis of knock out mouse using microarray showed alteration of epidermal growth factor receptor (EGFR), however, it is unclear how EVI1 acts in brain tumor cells. High EGFR gene expression and aberrant EGFR activation are common in patients with glioblastoma. We hypothesized that EVI1 regulates the EGF signaling in glioma initiating cells (GICs) and glioma cells. MATERIALS AND METHODS: GICs and gliomas cells were used for experiments. For differentiation assays, 0.5% serum media or serum free media without growth factors were used. For knockdown and enforced expression experiments, shEVI1 and wild type EVI1 were induced in GICs and glioma cells. For reporter assay, EGFR promoters including deletion mutants were inserted into pGL4 vectors. RESULTS: Overexpression of EVI1 increased EGFR mRNA and protein. To know whether EVI1 transcriptionally regulates EGFR gene expression, we performed promoter assay. EGFR promoter with or without EVI1 expression vector were transfected into glioma cell line. Promoter assay showed that EVI1 act on 300 to 370bp upstream of transcriptional starting site and increase promoter activity. Interaction between EVI1 and EGFR promoter was confirmed with ChIP. Differentiation experiments showed that high EVI and EGFR expression was observed in GICs but not in differentiated cells. Withdraw of EGF from growth medium of GICs decreased sox2 and nestin mRNA. Knockdown of EVI1 in GICs decreased EGFR and nestin mRNA. CONCLUSION: EVI1 maintains undifferentiated status of GICs through transcriptional regulation of EGFR gene expression.
Ultrafast nonlinear refractivity of Lead Lantum Zirconate Titanate Ceramics (2011)

Here we will report that nonlinear refractivity and its temporal response of Lead Lantanum Zirconate Titanate ceramics were almost comparable to those of SrTiO3 single crystal, one of the most excellent solid-state optical Kerr materials.
Thermal fluctuations and NMR spectra of incommensurate systems (1992)

In the presence of thermal fluctuations the incommensurate NMR line shape is a convolution of a static inhomogeneous with a dynamic homogeneous line shape which can be determined separately by 2D NMR. The form of the dynamic line shape and its variation over the inhomogeneous NMR spectrum permit a separate determination of the relative sizes of the phason and amplitudon fluctuations, compared to the static part of the order parameter. $^{87}\mathrm{Rb}$ 2D spectra of ultrapure ${\mathrm{Rb}}_{2}$${\mathrm{ZnCl}}_{4}$ agree with the above theory and show the existence of a temperature range where the incommensurate splitting induced by the static part of the order parameter is averaged out by thermal fluctuations.
Laparoscopy: new applications of an established technique. (1992)

The safety and cost-effectiveness of any new procedure is, of course, brought into question in this era of heightened fiscal concerns. In general, a review of initial results with laparoscopic pelvic lymph node dissection appears to reveal sufficient patient benefits to warrant further work with these less invasive techniques. The principal benefits include the following: Decreased patient morbidity, early and latent; Shorter hospitalization; Faster recovery and return to normal daily functions; Equivalent efficacy to open surgical alternatives; Overall cost-effectiveness Cosmetic effect; minimizes loss of body image; Reproducible results. Perfecting the skills necessary for complicated laparoscopic surgery requires a commitment of time and work on the part of the surgeon. This is not a procedure that will be learned by auditing a few cases. Laparoscopic surgery requires diligence in mentally and physically preparing the skills needed for surgery and caution in the application of these skills. Nurses can help to minimize this learning curve by taking an active interest in the current and future practice of laparoscopic surgery and by sharing their knowledge and enthusiasm.
Dendritic macromolecules as nano-scale drug carriers: Phase solubility, in vitro drug release, hemolysis and cytotoxicity study (2015)

Potential of nanoscale triazine based dendritic macromolecules G1, G2 and G3 as solubility enhancers of drug was investigated. Effect of pH, concentration and generation of synthesized dendritic macromolecules on solubility of ketoprofen was studied. G3 dendrimer was further exploited as carrier for sustained release. Ketoprofen was encapsulated by inclusion complex method and also characterized by Flourier Transform Infrared spectroscopy. Sustained release study of ketoprofen from ketoprofen loaded dendrimer was carried out and compared with free ketoprofen. Hemolytic potential and Cytotoxicity assay using A-549 lung cancer cell lines revealed that synthesized triazine based dendritic macromolecules having more potential that commercially available PAMAM dendrimer.
Turbine Missile Perforation of Reinforced Concrete (1984)

Improved empirical methods for the prediction of perforation of reinforced concrete barriers by missiles produced by turbine fracture are developed. Data from recent turbine missile tests and existing empirical methods of perforation damage analysis were collected and compared. Selected formulas were chosen for improvement. For each, modifications are proposed which result in a more accurate prediction of the occurrence of perforation of reinforced concrete barriers by missiles typical of those that might be found at nuclear power generating facilities. Also, a method is given to allow perforation analysis of reinforced concrete barriers with a thin steel plate affixed to the back face.
As flowers are beginning to dazzle the eyes, an old horse knowing his way need no push ——views of glucose-lowering therapy for cardiovascular disease in diabetes (2019)

降糖治疗对心血管预后的影响一直广受关注。研究显示，糖尿病治疗中多重危险因素的干预一个都不能少，干预效果越好则患者的心血管结局就越好。糖化血红蛋白是心肌梗死和脑卒中事件公认的预测因素，因此糖尿病治疗中设定接近正常值的血糖目标或可带来心血管获益。磺脲类药物是降糖效果最强的口服降糖药之一。此类药物对心血管结局的影响可能与其使用方式相关，临床使用时应注意进行高度个体化治疗。
Стабилизация поливинилхлорида серой (2003)

The inhibiting influence of sulphur on process of thermal and thermooxidation dehydrochlorination hard and plasticized polyvinylchloride is investigated.
The Effect of Adjuvanting Cancer Vaccines with Herpes Simplex Virus Glycoprotein D on Melanoma-Driven CD8+ T Cell Exhaustion (2014)

Two vaccines expressing CD4(+) and CD8(+) T cell epitopes of melanoma-associated Ags (MAAs) by a chimpanzee-derived replication-defective AdC68 vector were compared in a mouse model of melanoma. In one vaccine, termed AdC68-gDMelapoly, the epitopes were expressed as a fusion protein within HSV-1 glycoprotein D (gD), which blocks immunoinhibitory signaling through the herpes virus entry mediator pathway. The other vaccine, termed AdC68-Melapoly, expressed only the MAA epitopes. AdC68-gDMelapoly induced more potent MAA-specific CD8(+) T cell responses especially to the subdominant MAA epitopes. Upon prophylactic vaccination, mice that developed CD8(+) T cell responses to the two vaccines that were comparable in magnitude showed equal protection against tumor challenge. When mice were first challenged with tumor cells and then vaccinated results differed. In animals with comparable CD8(+) T cell responses, the AdC68-gDMelapoly vaccine was more efficacious compared with the AdC68-Melapoly vaccine in delaying tumor growth. This effect was linked to reduced expression of 2B4, LAG-3, and programmed death-1 on tumor-infiltrating MAA-specific CD8(+) T cells elicited by the gD-adjuvanted vaccine, suggesting that CD8(+) T cells induced in presence of gD are less susceptible to tumor-driven exhaustion.
Editorial (2003)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Photodissociation mass spectrometry: new tools for characterization of biological molecules (2014)

Photodissociation mass spectrometry combines the ability to activate and fragment ions using photons with the sensitive detection of the resulting product ions by mass spectrometry. This combination affords a versatile tool for characterization of biological molecules. The scope and breadth of photodissociation mass spectrometry have increased substantially over the past decade as new research groups have entered the field and developed a number of innovative applications that illustrate the ability of photodissociation to produce rich fragmentation patterns, to cleave bonds selectively, and to target specific molecules based on incorporation of chromophores. This review focuses on many of the key developments in photodissociation mass spectrometry over the past decade with a particular emphasis on its applications to biological molecules.
Toll-like Receptor Polymorphisms and Age-Related Macular Degeneration: Replication in Three Case–Control Samples (2009)

Even with previously verified samples sets and adequate study powers, the results did not confirm the reported associations of TLR3 rs3775291 and TLR4 rs4986790 with AMD in the three independent samples, individually or combined.
4-Aminopyridine Decreases Progesterone Production by Porcine Granulosa Cells (2003)

4-AP inhibits basal and FSH-stimulated progesterone production by pig granulosa cells via drug action at multiple interacting steps in the steroidogenic pathway. These inhibitory effects of 4-AP on steroidogenesis may reflect drug-induced changes in intracellular concentrations of K+and Cl- as well as granulosa cell resting membrane potential.
Contact-damage resistance in alumina-based ceramics with elastic-modulus-graded surfaces (1999)

Hertzian (spherical) indentation experiments were carried out in a graded alumina-glass composite whose Young's modulus (E) increased with depth (z) beneath the indented surface. An in-situ processing method involving impregnation of a dense, fine-grained alumina by an aluminosilicate glass was employed to fabricate such a composite. With this technique, a monotonic, unidirectional variation in Young's modulus of as much as 50% was introduced over a distance of approximately 2 mm, while keeping the coefficient of thermal expansion (CTE) and the Poisson ratio (ν) for the glass and the alumina nearly the same. The macroscopically graded, elastic composites so produced with nearly full density have no macroscopic, long-range residual stresses following processing. The unidirectional variation in Young's modulus under the indenter is shown to fully suppress the formation of Hertzian one cracks. Without these elastic-modulus gradients, cone-crack formation was observed in bulk glass and alumina. Finite element analyses of spherical indentation on elastically graded substrates were also performed to develop a quantitative understanding of the experiment trends. ^ The wear properties of those composites were also measured, and it was found that the wear resistance is high for shorter sliding time, but low for longer sliding time. It is reasoned that the present innovations, involving functionally-graded surfaces and their in-situ processing, provide new possibilities for enhancing certain contact-damage and wear resistance characteristics in various ceramic materials for a broad range of engineering applications. ^
Handoff of application sessions across time and space (2002)

Personal computing on mobile platforms such as laptops and personal digital assistants, rather than in a traditional desktop environment, is becoming increasingly more common. We address the issue of application session transfer for uninterrupted data access across this diverse range of platforms. This work is part of the iMASH project, a multi-year, multi-discipline collaborative effort focused on enabling mobile client platforms and incorporating them into existing legacy networked systems for use by medical practitioners. We have developed a tiered architecture that includes a middleware server layer positioned between existing application servers and multiple clients to make session transfer transparent to the user. Any client application executing our middleware-aware remote code library can save and restore its session by interacting with a middleware server. As a proof of concept, we have implemented the transfer of bookmarks, history, Web cache, and user preferences with the Mozilla open source Web browser, from this effort we have established baseline performance metrics and have found that the overhead is within reasonable bounds of just a few seconds of latency.
Capability-based addressing (1974)

Various addressing schemes making use of segment tables are examined. The inadequacies of these schemes when dealing with shared addresses are explained. These inadequacies are traced to the lack of an efficient absolute address for objects in these systems. The direct use of a capability as an address is shown to overcome these difficulties because it provides the needed absolute address. Implementation of capability-based addressing is discussed. It is predicted that the use of tags to identify capabilities will dominate. A hardware address translation scheme which never requires the modification of the representation of capabilities is suggested. The scheme uses a main memory hash table for obtaining a segment's location in main memory given its unique code. The hash table is avoided for recently accessed segments by means of a set of associative registers. A computer using capability-based addressing may be substantially superior to present systems on the basis of protection, simplicity of programming conventions, and efficient implementation.
A Data-Fitted Rolling Bearing Life Prediction Model–-Part I: Mathematical Model (1996)

Paris I through III of this paper present the results of a project aimed at creating an improved rolling bearing spalling fatigue life prediction method. (a) A large experimental bearing life database is assembled. (b) A mathematical life prediction model is formulated that includes traction, EHD film and surface roughness effects and numerous bearing material, design, manufacturing and operating parameters. (c) The model is fitted to the database and its fit statistically evaluated. (d) The model is compared with major published models and parametrically explored. (e) Applicability of the model to rolling bearing design tasks is reviewed. The present paper is Part I, the mathematical model.
Directional prediction of stock prices using breaking news on Twitter (2017)

Stock market news and investing tips are popular topics in Twitter. In this paper, first we utilize a 5-year financial news corpus comprising over 50,000 articles collected from NASDAQ website matching 30 stock components in Dow Jones Index (DJI) to train a directional stock price prediction system based on news content. Next, we proceed to show that information in articles indicated by breaking Tweet volumes leads to a statistically significant boost in hourly directional prediction accuracies for the DJI stock prices mentioned in these articles. Secondly, we show that using document-level sentiment extraction does not yield a statistically significant boost in the directional predictive accuracies in the presence of other 1-gram keyword features. Thirdly we test the performance of the system on several time-frames and identify 4 hour time-frame for both the price charts and for Tweet breakout detection as the best time-frame. Finally, we develop a set of price momentum based trade exit rules to cut losing trades early and to allow winning trades run longer. We show that the Tweet volume breakout based trading system with price momentum based exit rules not only improve the winning accuracies and the return on investment, but they also lower the maximum drawdown and achieve highest overall return over maximum drawdown.
Demonstration of a Mems-Mirror, 3D-Lidar System with Large Aperture and Scanning Angle (2019)

The state of the art of miniaturized LiDAR systems for autonomous-car applications require large mirror surfaces for eye-safe transmission (Tx) beams and long measurement ranges. Our system concept incorporates a MEMS mirror and an optimized micro-optical array for avoidance of shadings in the field of view (FoV) and high light-collection efficiency. This realizes constant angular resolution, high robustness against front lens contamination and long measurement ranges for an eye-safe laser class 1 LiDAR system. In this paper, we demonstrate first real distance measurements and proof by simulations and experiments the behavior of shadings in the FoV regarding the receiving (Rx) signal, due to beam cut-offs at the aperture-stop of the scanner module.
Bytecode verification on Java smart cards (2002)

Abstract This article presents a novel approach to the problem of bytecode verification for Java Card applets. By relying on prior off‐card bytecode transformations, we simplify the bytecode verifier and reduce its memory requirements to the point where it can be embedded on a smart card, thus increasing significantly the security of post‐issuance downloading of applets on Java Cards. This article describes the on‐card verification algorithm and the off‐card code transformations, and evaluates experimentally their impact on applet code size. Copyright © 2002 John Wiley &amp; Sons, Ltd.
Supplementary Figure 1 from 14-3-3ζ, a Novel Androgen-Responsive Gene, Is Upregulated in Prostate Cancer and Promotes Prostate Cancer Cell Proliferation and Survival (2023)

&lt;p&gt;PDF file, 152K, Elevated motility by 14-3-3ζ overexpression in LNCaP cells.&lt;/p&gt;
Characterization of Streptococcus lutetiensis isolated from clinical mastitis of dairy cows (2020)

Streptococcus lutetiensis, previously termed Streptococcus bovis type II/1, has rarely been associated with bovine mastitis. The objectives of this work were to characterize the molecular diversity, antimicrobial resistance profiles, virulence genes of Strep. lutetiensis (n = 37) isolated from bovine clinical mastitis, as well as its pathogenic effects in a murine mastitis model. Genetic relationships of isolates were determined by random amplified polymorphic DNA (RAPD)-PCR, virulence genes were detected by PCR. Antimicrobial susceptibility testing was carried out by broth microdilution technique. The pathogenic effects of Strep. lutetiensis were studied with 2 infection models: bovine mammary epithelial cells cultured in vitro and murine mammary infection in vivo. Streptococcus lutetiensis isolates were clustered into 5 RAPD-types (A-E), with a dominant type A representing 84% of isolates. Eighteen (49%), 16 (43%), and 9 (24%) isolates were resistant to ceftiofur, tetracycline, and erythromycin, respectively. Prevalence of multidrug resistance (resistant to ≥3 classes of antimicrobials) was 24% (9/37). The most prevalent virulence genes were bca (100%), speG (100%), hly (97%), scpB (95%), and ssa (95%). There was no difference between isolates from mild and moderate cases of bovine mastitis in prevalence of virulence genes. Streptococcus lutetiensis rapidly adhered to and subsequently invaded (1 and 3 h after infection, respectively) bovine mammary epithelial cells, resulting in elevated lactate dehydrogenase release (4 h after infection). Edema and hyperemia were observed in challenged mammary glands and bacteria were consistently isolated at 12, 24, and 48 h after infection. In addition, numerous neutrophils migrated into gland alveoli and interstitium of infected mammary tissue. We concluded that Strep. lutetiensis had potential to spread within a dairy herd and good adaptive ability in bovine mammary cells or tissue, which are generally characteristics of a contagious mastitis pathogen.
Voltage source inverter fault diagnosis in variable speed AC drives, by Park's vector approach (1998)

This paper presents the use of the Park's vector approach for diagnosing voltage source inverter faults, like output single-phasing and the occurrence of either a short-circuit or an open circuit of the controlled power switches. For this study, a prototype was built, having all the power terminals available for testing, including the ones for every semiconductor. For the short-circuit tests, a 17 /spl Omega/ auxiliary resistor was used, connected in parallel with the power switch to be tested, in order to limit the short-circuit current.
The Effects of Reading Speed on Visual Search Task (2005)

Speed reading training enhances one's reading speed.Typically, those who train using the Park-Sasaki training method can read all the characters sequentially with the reading speed of over 10,000 characters per minute (about over 4,000 words per minute in English sentences).It means that they take in a huge amount of information during speed reading.Our study investigated the training effect on visual perception and attention using a visual search task and revealed that speed reading changes the performance of a visual search task.In the conjunction task, compared with novices, the slope of response times for experts as a function of set size was shallow, which suggests that experts watch a wider area than do novices, or that experts conduct a parallel search, at least in part.The measurements of eye movements during the experiments support this explanation; experts could respond with fewer episodes of fixation than could novices.As we used a simple non-letter-based feature as the stimulus, the results suggest that training improves general ability to process visual stimuli, regardless of language.We think that speed reading training improves attention which plays an important role in the conjunction task.
Capturing and Training Motor Skills (2010)

We have built an intelligent multimodal interface to capture, understand and correct in real time a complex hand/arm gestures performed inside its workspace. The interface is formed by a commercial vision tracking system, a commercial PC and feedback devices: 3D sound system, a cave like VE and a pair of wireless vibrotactile devices. The interface can capture the upper part limbs kinematics of the user independently of the user's size and high. The interface recognizes complex gestures due a novel recognition methodology based on several machine-learning techniques such as: dynamic k-means, probabilistic neural networks and finite state machines. This methodology is the main contribution of this research Human Hand Computer Interaction research area, its working principle is simple: a gesture is split in several states (a state is an ensemble of variables that define an static position or configuration), the key is obtain the optimal number of states that define
Specificity of zinc pathway through the body: turnover of Zn65 in the mouse (1962)

An isotopic study is presented which shows that zinc metabolism is controlled by at least two homeostatic mechanisms which act at the sites of absorption and of intestinal excretion, respectively. Zinc was the only element which, when used as a metabolic load, accelerated the elimination of Zn 65 . Among its neighbors in the transition series, copper and gallium were ineffectual. Among the members of group II of the elements cadmium decelerated the excretion of Zn 65 slightly, whereas magnesium was without demonstrable effect. The significance of these findings relative to the specificity of zinc's pathway through the body is discussed.