gebhart/patrepeval huggingface dataset:
USING OF FEM FOR CHIP FORMATION AND CUTTING FORCE PREDICTION WHEN DRILLING TOOL STEEL AISI D3 (2011)

Initial enthusiasm for the parallel kinematics in the eighties of the last century slumped significantly during the last twenty years.There were found some disadvantages of standard parallel kinematic structures.The experts around the world began to seek new solutions of outlined problems.They defined several possible ideas which could eliminate the drawbacks and improve the properties and advantages of parallel machines.One of these ways was also the application of mechanisms based on the kinematic structure that consisted of serial and parallel substructures as well.This article is focused on the development of mechanism with hybrid kinematic structure called Trivariant.This mechanism is similar to the well-known and succesful concept called Tricept, represented by various machines.
Beryllium nitrogen compounds. 1. Monomeric bis(amido)beryllium compounds (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBeryllium nitrogen compounds. 1. Monomeric bis(amido)beryllium compoundsHeinrich Noeth and Dieter SchlosserCite this: Inorg. Chem. 1983, 22, 19, 2700–2703Publication Date (Print):September 1, 1983Publication History Published online1 May 2002Published inissue 1 September 1983https://pubs.acs.org/doi/10.1021/ic00161a012https://doi.org/10.1021/ic00161a012research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Suppression of the Oncogenic Transcription Factor FOXM1 by Proteasome Inhibitors (2014)

The oncogenic transcription factor FOXM1 is one of the key regulators of tumorigenesis. We found that FOXM1 upregulates its own transcription and its protein stability depends on its interaction with the chaperone nucleophosmin. We also determined that FOXM1 is negatively regulated by the tumor suppressor p53. We identified the thiazole antibiotics Siomycin A and thiostrepton as inhibitors of transcriptional activity and FOXM1 expression via proteasome inhibition. In addition, we found that all tested proteasome inhibitors target FOXM1. We showed synergy between thiostrepton and bortezomib in different human cancer cell lines and in vivo. We generated isogenic human cancer cell lines of different origin with wild-type p53 or p53 knockdown and we demonstrated that proteasome inhibitors induce p53-independent apoptosis in these cells. Using RNA-interference or proteasome inhibitors to inhibit FOXM1 we found that suppression of FOXM1 sensitized human cancer cells to apoptosis induced by DNA-damaging agents or oxidative stress. We encapsulated thiostrepton into micelle-nanoparticles and after injection we detected accumulation of nanoparticles in tumors and in the livers of treated mice. This treatment led to inhibition of human xenograft tumor growth in nude mice. Our data indicate that targeting FOXM1 increases apoptosis and inhibits tumor growth.
Abstract C170: Inhibition of poly(ADP-ribose) polymerase (PARP) increases the therapeutic efficacy of the G-quadruplex ligand RHPS4/irinotecan combination in cancer xenografts (2009)

Abstract Background and Aim: The G-quadruplex ligand RHPS4 is known to induce a rapid activation of DNA damage response at telomeres and poly (ADP-ribosyl)ation is involved in the regulation of many cellular processes such as DNA damage repair. We recently showed that the combination of RHPS4 with camptothecins has a strong synergistic interaction in vitro on colon cancer lines and produced a marked antitumor activity on xenografts. Unfortunately, this combination failed to cure animals as no complete remissions were reported. So, based on the observation that PARP inhibitors sensitize tumor cells to camptothecins and in the attempt to search for a more effective anticancer therapy, we evaluated a multicomponent strategy based on the addition of the PARP inhibitor GPI 15427 to the previously established camptothecins/ RHPS4 combination. Material and Methods: PARP activity and poly(ADP-ribose) formation have been evaluated in cells upon RHPS4 treatment. Moreover, the presence of poly(ADP-ribose) at the telomeres has been investigated by coimmunofluorescence experiments using an anti-TRF1 antibody to mark telomeres. The involvement of PARP activity in the cellular response to RHPS4 has been studied by treatment with the PARP inhibitor GPI 15427 followed by analysis of the formation of TIFs (Telomeres Disfunction Induced Foci) and evaluation of the clonogenic ability of the human colon carcinoma cells line HT29. In vivo experiments were performed on HT29 xenografts to evaluate the therapeutic efficacy of GPI 15427/Irinotecan/RHPS4 combination. Results and Conclusions: RHPS4 produced a rapid induction of PARP activity and, interestingly, most of the ADP-ribose polymers induced by RHPS4 were localized at telomeres. Consistently with these results, the PARP-1 protein was found to be localized at telomeres upon drug treatment, thus providing a rational for RHPS4 and PARP inhibitors combination. Indeed, RHPS4/GPI 15427 combination strongly increased the number of TIFs/cell and reduced the survival of HT29 cells compared to the treatment with RHPS4 alone. The in vivo experiments confirmed these results and demonstrated the high efficacy of GPI 15427/Irinotecan/RHPS4 combination as this multicomponent strategy produced an impressive inhibition of tumor weight and a marked tumor growth delay. Notably, after the triple combination a complete regression of tumors was observed in most of the mice treated accompanied by a significant increase of overall survival. Finally, a complete cure of about 50% of mice was observed. Interestingly, this treatment remained effective even when started at a very late stage of tumor growth. In conclusion, these data suggest that the integration of a PARP inhibitor with Irinotecan/RHPS4 combination could be a promising strategy to improve the response of solid tumors to antitumoral agents. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):C170.
Carbamoyl Azides of α-N-Protected Amino Acids: A Fast and Simple One-Pot Synthesis (2008)

A fast and simple one-pot synthesis of carbamoyl azides of α-N-protected amino acids is reported. The procedure involves the reaction between sodium azide and the mixed anhydride obtained from an α-N-protected amino acid and isobutyl chloroformate, in the presence of KH2PO4. The reaction rate was influenced by the nature of both the α-N-protection and the amino acid side chain. Surprisingly, tert-butyloxycarbonyl (α-N-Boc) and benzyloxycarbonyl (α-N-Cbz) protected proline afforded the corresponding isocyanates instead of the expected carbamoyl azides.
Sulfur Amino Acid Requirements and Interactions in Broilers During Two Growth Periods (1981)

Total sulfur amino acid (TSAA) requirements and methionine and cystine combinations were investigated during two growth phases (0 to 21 days and 21 to 42 days) of broilers using practical-type diets. For the first growth phase (0 to 21 days), the basal diet contained .62% TSAA to which increasing increments of DL-methionine were added. Both overall growth and feed efficiency improved as methionine levels increased to a level of .82% TSAA. When methionine-cystine combinations were used with the same basal diet, it was found that cystine could supply 54% of the TSAA content. When expressed on a millimolar basis, the methionine requirement was 41%, while cystine could account for 59% of the TSAA's. During the second growth phase (21 to 42 days) a basal diet consisting of .52% TSAA was used along with DL-methionine supplements to determine sulfur amino acid requirements. The trend was towards a slight decrease in requirement from .82% during the first growth period, to between .70% and .76% TSAA in the diet, represented mainly by methionine. When sulfur amino acid combinations were used during this period it appeared the replacement value of cystine for methionine decreased to between 38 and 43% of the TSAA level. Results also suggested that a more efficient way to express the sulfur amino acid requirement may be on a mole per unit of feed basis.
Advanced super-resolution image enhancement process (2008)

An advanced SRIE (super-resolution image enhancement) process has been developed for improving image resolution, for enhancing image signal-to-noise ratio (SNR) and contrast, as well as for correcting image blur and distortion caused by atmospheric turbulence. The SRIE process is composed of five sub-processes: 1) over-sampling process, 2) image registration process, 3) image averaging process, 4) high-pass filtering process, and 5) histogram-equalization process. These five sub-processes are discussed in detail in this paper. Performance of SRIE process was tested using a long wave infrared (LWIR) imagery and charge-coupled device (CCD) camera video imagery.
The 1,1,1-triaryl-2,2,2-trifluoroethanes and process for their synthesis (1981)

New 1,1,1-triaryl-2,2,2-trifluoroethanes in which the aryl radicals carry one or more substituents were prepared by condensation of trifluoroacetophenones with substituted phenyl compounds in the presence of catalytic quantities of trifluoromethylsulfonic acid. The reaction can be carried out under reflux in toluene or, for strikingly better results in certain cases, reactants are simply stirred at room temperature for about 24 to 48 hours.
On the controllability and observability of Cartesian product networks (2012)

The paper presents an analysis framework for a class of dynamic composite networks. These networks are formed from smaller factor networks via graph Cartesian products. We provide a composition method for extending the controllability and observability of the factor networks to that of the composite network. We then delve into the effectiveness of designing control and estimation algorithms for the composite network via symmetry in the network. Examples and applications are provided throughout the paper to demonstrate the results including a distributed output feedback stabilizer and a social network application.
On‐farm monitoring of soil and crop nitrogen status by nitrate‐selective electrode (1993)

Abstract Nitrate‐nitrogen concentration in fresh petiole sap, as measured by a portable, battery‐operated, nitrate‐selective electrode, was highly correlated with NO3‐N concentration in dry petiole tissue of broccoli [Brassica oleracea L. (Italica group), r2 = 0.84], celery [Apium graveolens L. var. dulce (Mill.) Pers., r2 = 0.88], lettuce (Lacluca saliva L., r2 = 0.77), pepper (Capsicum annuum var. annuum L., r2 = 0.89), tomato (Lycopersicon esculentum Mill., r2 = 0.83), and watermelon [Citrulius lanatus (Thunb.) Matsum. & Nakai, r2 = 0.88]. This relationship was linear over a wide range of NO3‐N values and was generally unaffected by site, crop, cultivar, or growth stage, provided that petiole tissue analyzed was from recently matured leaves. Sap was analyzed directly without dilution or filtration. The slope of the regression equation differed widely among crops. Selective electrode analysis of NO3‐N concentration of soil solution samples obtained by suction lysimetry was also highly correlated with conventional laboratory technique (r2 = 0.87). The nitrate‐selective electrode appeared to be a useful tool for on‐farm monitoring of soil and crop N status.
Blunted Evoked Prouroguanylin Endocrine Secretion in Chronic Constipation (2019)

This study suggests that CIC and IBS-C can be treated by oral GUCY2C hormone replacement. Indeed, these observations provide a mechanistic framework for the clinical utility of oral GUCY2C ligands like plecanatide (Trulance) and linaclotide (Linzess) to treat CIC and IBS-C.
Magnetic Properties of Hot-Pressed <inline-formula> <tex-math notation="TeX">${\rm FeSb}_{{2}}$ </tex-math></inline-formula> (2014)

We report on the magnetic properties of a hot-pressed FeSb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> sample. We find a significant increase in the magnetic susceptibility in our sample when compared with the values previously reported for the polycrystalline sample. The pronounced Curie tail at low temperature corresponds to 0.2% of Fe <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup> impurities per mole. In the intrinsic conductivity region, the susceptibility due to free carriers shows thermally activated behavior and is consistent with the data reported for single crystal FeSb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> . Based on our data and analysis, while the enhanced magnetic susceptibility in our sample comes mainly from a small amount of unreacted Fe, the contribution from the enhanced carrier density due to lattice and strain defects arising from the ball milling process is also significant. Existence of an unreacted Fe phase is evidenced by small coercivity values of ~100 observed at 50 and 300 K.
Recent advances in memory-based part-of-speech tagging (1999)

Memory-based learning algorithms are lazy learners. Examples of a task are stored in memory and processing is largely postponed to the time when new instances of the task need to be solved. This is then done by extrapolating directly from those remembered instances which are most similar to the present ones. Using memory-based learning for Part-of-Speech tagging has a number of advantages over traditional statistical POS taggers: (i) there is no need for an additional smoothing component for sparse data, (ii) even low-frequent or exceptional patterns can contribute to generalization, (iii) the use of a weighted similarity metric allows for an easy integration of different information sources, and (iv) both development time and processing speed are very fast (in the order of hours and thousands of words/sec, respectively). In recent work, we have applied the Memory-Based tagger (MBT) to a number of different languages and corpora (English, Dutch, Czech, Swedish, and Spanish). Furthermor...
New soft-switched/switched-reluctance motor drive circuit (1999)

A new soft-switched three-phase switched-reluctance motor drive circuit that uses only four transistors is proposed. The circuit produces less EMI due to the application of soft switching, and the output torque is increased by means of a shorter current tail. Moreover, because the proposed circuit utilizes only one series switching device between the DC source and the winding, system efficiency is also increased.
Effectiveness of cisplatin in the treatment of anal squamous cell carcinoma. (1985)

The therapeutic activity of cisplatin was explored in three consecutive patients with locoregional squamous cell carcinoma of the anus who received no prior therapy. One complete response and two partial responses were achieved. These data, although preliminary, strongly suggest that this disease is sensitive to cisplatin, and further trials are indicated to assess the precise role of this drug in the overall management of anal carcinoma.
Optimal Coordination of a Multiple HVDC Link System Using Centralized and Distributed Control (2012)

This paper presents both offline and online optimization techniques for the control of a multiple high voltage direct current link power system. A frequency control scheme based on classical proportional-integral-derivative controllers is proposed and optimally tuned offline using particle swarm optimization. The performance of this scheme is compared with the performance of a centralized model predictive control (MPC) scheme, and a distributed MPC scheme that uses only local communications. The results illustrate that a significant performance improvement can be achieved using distributed MPC instead of classical control, illustrating the potential of distributed MPC for use in future power networks.
Honey-Based Salve and Burdock Leaf Dressings as an Alternative to Surgical Debridement of a Traumatic Wound Eschar (2018)

<b>Objective:</b> Nonviable necrotic eschar is an impedance to wound healing and can ultimately lead to failure of soft tissue coverage in traumatic or high-risk wounds. Topical therapeutic agents can provide a less invasive management alternative to surgical debridement of eschar. <b>Approach:</b> The case of a 40-year-old male with a traumatic right lower extremity amputation complicated by surgical incision ischemic eschar formation is reported. Honey-based salve with burdock leaf dressings was used to noninvasively manage eschar extending over the incision site. Images were obtained for 5 months of follow-up. <b>Results:</b> Five-month follow-up demonstrated complete resolution of eschar and re-epithelialization of skin in the affected region. <b>Innovation:</b> Honey-based salve with burdock leaf dressings shows promise for enhancing healing outcomes in traumatic wounds that develop nonviable eschar. <b>Conclusion:</b> Surgical debridement of an amputation stump with large ischemic eschar was avoided with the use of honey-based salve with burdock leaf dressings.
Identification and RNAi‐based function analysis of chitinase family genes in diamondback moth, Plutella xylostella (2018)

Abstract BACKGROUND Insect chitinases play a vital part in chitin degradation in exoskeletons and gut linings during the molting process, and therefore are considered potential targets for new insecticide designs or RNA interference (RNAi)‐based pest management. Systematic functional analysis of chitinase genes has already been conducted in several insect pests, but not Plutella xylostella . RESULTS In this study, 13 full‐length chitinase transcripts were obtained in P. xylostella . Developmental and tissue‐specific expression pattern analysis revealed that seven chitinase transcripts were periodically expressed during molting stage and mainly expressed in the integument or midgut, including PxCht3 , PxCht5 , PxCht6‐2 , PxCht7 , PxCht8 , PxCht10 and PxCht‐h . RNAi‐mediated knockdown of these specific expressed genes revealed that PxCht5 and PxCht10 were essential in larval molting, pupation and eclosion, and PxCht7 was indispensable only in eclosion. No significant effects were observed on insect survival or normal development when the rest chitinase transcripts were suppressed by RNAi. CONCLUSION Our results indicated the function of P. xylostella chitinase family genes during the molting process, and may provide potential targets for RNAi‐based management of P. xylostella . © 2018 Society of Chemical Industry
Bioemulsifier production by Microbacterium sp. strains isolated from mangrove and their application to remove cadmiun and zinc from hazardous industrial residue (2009)

The contamination of ecosystems with heavy metals is an important issue in current world and remediation technologies should be in according to environmental sustainability concept. Bioemulsifier are promising agents to be used in metal removal and could be effective to many applications in environmental industries. The aims of this work was screening the potential production of bioemulsifier by microorganisms isolated from an oil contaminated mangrove, and evaluate cadmium and zinc removal potential of those strains from a hazardous industrial residue. From that, bioemulsifier-producing bacteria were isolated from urban mangrove sediments. Four isolates were identified as Microbacterium sp by 16S rRNA analysis and were able to reduce up to 53.3% of culture medium surface tension (TS) when using glucose as carbon and energy source and 20.2% when sucrose was used. Suspensions containing bioemulsifier produced by Microbacterium sp. strains show to be able to remove cadmium and zinc from contaminated industrial residue, and its ability varied according carbon source. Significant differences in metal removal were observed by all strains depending on the carbon source. When glucose was used, Cd and Zn removal varied from 17 to 41%, and 14 to 68%, respectively. However, when sucrose was used it was observed only 4 to a maximum of 15% of Cd removal, and 4 to 17% of Zn removal. When the same tests were performed after ethanol precipitation, the results were different: the percentages of removal of Zn (7-27%) and Cd (14-32%) were higher from sucrose cultures. This is the first report of heavy metals removal by bioemulsifier from Microbacterium sp.
Calreticulin Binds to Fas Ligand and Inhibits Neuronal Cell Apoptosis Induced by Ischemia-Reperfusion Injury (2015)

This study for the first time revealed that increased CRT inhibited Fas/FasL-mediated neuronal cell apoptosis during the early stage of ischemic stroke, suggesting it to be a potential protector activated soon after IRI.
Pulse Method of Measuring Thermal Diffusivity at High Temperatures (1963)

Equations are derived giving the temperature distribution within a thin slab of material which has received a short pulse of energy on one surface, for the case in which energy loss at the surfaces (by radiation or convection) is not negligible. An analysis of these equations indicates that measurement of thermal diffusivity by the pulse method should be feasible even when losses are so large that the maximum temperature of the far face is only 10 or 20% of the no-loss value; this includes nearly all materials, and temperatures to 2500°K or higher.
Using the Wireless and PLC Channels for Diversity (2012)

Performance of indoor home networks can be improved by simultaneous use of wireless and powerline communication (PLC) channels. A narrowband model representing an OFDM subcarrier is used to analyze the performance of several diversity combining schemes including optimum combining (OC), saturated metric combining (SMC) and maximal ratio combining (MRC). Results from BER analysis show that SMC achieves good performance in highly impulsive noise and is relatively insensitive to error in noise parameter estimates. Indoor measurements from 3 detached homes show that parallel wireless and PLC channels have a wide, but similar, signal-to-noise ratio (SNR) range. Measurement data is used with link throughput analysis to show that wireless/PLC diversity can be used to minimize the likelihood of low throughput links.