gebhart/patrepeval huggingface dataset:
Differential Vulnerability of the CA1 and CA3 Subfields of the Hippocampus to Superoxide and Hydroxyl Radicals In Vitro (1997)

The relative roles of the superoxide and hydroxyl radicals in oxidative stress-induced neuronal damage were investigated using organotypic hippocampal slice cultures. Cultures exposed to 100 microM duroquinone, a superoxide-generating compound, for 3 h developed CA1-selective lesions over a period of 24 h. The damage accounted for approximately 64% of the CA1 subfield, whereas CA3 showed just 6% damage, a pattern of damage comparable to that observed following hypoxia/ischaemia. Duroquinone-induced damage was attenuated by a spin-trap agent. In contrast, hydroxyl radical-mediated damage, generated by exposure to 30 microM ferrous sulphate for 1 h, resulted in a CA3-dominant lesion. The damage developed over 24 h, similar to that observed with duroquinone, but with approximately 45% damage in CA3 compared with only 7% in CA1. These data demonstrate a selective vulnerability of the CA1 pyramidal neurones to superoxide-induced damage and suggest that of the free radicals generated following hypoxia/ischaemia, superoxide, rather than hydroxyl radical, is instrumental in producing neuronal damage.
Clickpattern: A pattern lock system resilient to smudge and side-channel attacks (2017)

Pattern lock is a very popular mechanism to secure authenticated access to mobile terminals; this is mainly due to its ease of use and the fact that muscle memory endows it with an extreme memorability. Nonetheless, pattern lock is also very vulnerable to smudge and side channels attacks, thus its actual level of security has been often considered insufficient. In this paper we describe a mechanism that enhances pattern lock security with resilience to smudge and side channel attacks, maintains a comparable level of memorability and provides ease of use that is still comparable with Pattern Lock while outperforming other schemes proposed in the literature. To prove our claim, we have performed a usability test with 51 volunteers and we have compared our results with the other schemes.
Cementless Fixation of "Isoelastic" Hip Endoprostheses Manufactured from Plastic Materials (1983)

Nine years of clinical experience with an "isoelastic" shaft prosthesis manufactured using polyacetal resin reveal that for the transmission of forces from the pelvis through the femoral head and neck into the femoral shaft, some rigidity of the proximal part of the prosthesis is necessary. The object is to eliminate micromovements, which lead to bone resorption and implant loosening. However, elasticity greater than that present in metallic implants prevents stress concentrations and disuse stress protection atrophy of the bone. Greater elasticity of the prosthesis, which can be achieved by plastic materials, makes possible a more even, harmonious distribution of the forces transmitted from the implant to the bone and vice versa. A more elastic implant can also act as a better shock absorber than a rigid one. The results in 627 cementless polyethylene cups after a maximum observation period of 5.5 years reveal good incorporation and no aseptic loosening. Especially favorable results occurred in 61 cases by replacing loosened cemented cups with bone grafts and cementless polyethylene cups. On the femoral shaft side too high an elasticity in the proximal part of the prosthesis led to bone resorption and loosening with the first model of the prosthesis. By reinforcing the proximal part of the femoral component, much better results were obtained. The isoelastic femoral shaft, however, is in an early stage of experimentation.
Learning tactile characterizations of object- and pose-specific grasps (2011)

Our aim is to predict the stability of a grasp from the perceptions available to a robot before attempting to lift up and transport an object. The percepts we consider consist of the tactile imprints and the object-gripper configuration read before and until the robot's manipulator is fully closed around an object. Our robot is equipped with multiple tactile sensing arrays and it is able to track the pose of an object during the application of a grasp. We present a kernel-logistic-regression model of pose- and touch-conditional grasp success probability which we train on grasp data collected by letting the robot experience the effect on tactile and visual signals of grasps suggested by a teacher, and letting the robot verify which grasps can be used to rigidly control the object. We consider models defined on several subspaces of our input data - e.g., using tactile perceptions or pose information only. Our experiment demonstrates that joint tactile and pose-based perceptions carry valuable grasp-related information, as models trained on both hand poses and tactile parameters perform better than the models trained exclusively on one perceptual input.
A deep learning model for novel systemic biomarkers in photographs of the external eye: a retrospective study (2023)

Google.
Tendon xanthomas in familial hypercholesterolemia are associated with a differential inflammatory response of macrophages to oxidized LDL (2005)

Tendon xanthomas (TX) are pathognomonic lipid deposits commonly found in familial hypercholesterolemia (FH) patients. The aim of this study was to determine whether macrophages from FH patients with TX (TX+) have higher predisposition to foam cells formation after oxidized LDL (oxLDL) overload than those from FH patients without TX (TX-), and if their differential gene expression profile could explain these different phenotypes. Total RNA pools from macrophages from FH patients TX+ and TX- were analyzed using Affymetrix oligonucleotide arrays to evaluate the gene expression profile in presence and absence of oxLDL. Also, the intracellular lipid content was measured by fluorescence flow cytometry. Results of these studies suggest that macrophages from FH subjects TX+ compared to those TX- have a differential response to oxLDL, since they show higher intracellular cholesterol ester accumulation and a differential gene expression profile. The gene array data were validated by relative quantitative real-time RT-PCR and quantitative ELISA in culture media and plasma samples. FH subjects TX+ showed increased plasma tryptase, TNF-alpha, IL-8 and IL-6 concentrations. We propose that TX formation are associated with higher intracellular lipid content, and higher inflammatory response of macrophages in response to oxLDL.
ONE - POT SYN THESIS AND ANTIMICROBIAL ACTIVITY OF 2 - AMINO - 5 - ARYL - 5H - THIAZOLO (4,3 - b ) - 1,3,4 - THIADIAZOLES (2011)

A series of 2 - amino - 5 - aryl - 5H - thiazolo[4,3 - b] - l,3,4 - thiadiazoles were synthesized by using aromatic aldehydes, thioglycolic acid and thiosemicarbazide. Equimolar mixtures of aromatic aldehydes with thioglycolic acid and thiosemicarba zide in H 2 SO 4 transform into 2 - amino - 5 - aryl - 5H - thiazolo[4,3 - b] - l,3,4 thiadiazoles . Structures of all synthesized compounds were con firmed by FT IR, 1 H NMR and mass spectral data. Their antitubercular activity has been studied. All the synthesized compounds have shown good antitubercular activity.
Influence of oxygen precipitation on the measure of interstitial oxygen concentration in silicon from the 1207 cm−1 infrared absorption band (2002)

The possible use of the absorption band at 1207 cm−1 for the measurement of the concentration of interstitial oxygen (Oi) in silicon samples subjected to a precipitation thermal treatment is discussed. The results of low temperature infrared absorption measurements show that the conversion factor for such evaluation of the residual Oi after precipitation is strongly influenced by the presence of oxide precipitates; a limit value for the concentration of precipitated oxygen is identified, above which the measure becomes unreliable.
Impact of High-Normal Blood Pressure on the Risk of Cardiovascular Disease (2001)

High-normal blood pressure is associated with an increased risk of cardiovascular disease. Our findings emphasize the need to determine whether lowering high-normal blood pressure can reduce the risk of cardiovascular disease.
On multireference superdirect configuration interaction in third order (1994)

Abstract The superdirect configuration interaction (Sup‐ CI ) method has the usual versatility and stability of the CI methods with computational efficiency typical to that of the many‐body methods, such as the many‐body perturbation theory ( MBPT ). The Hamilton operator is projected into a space of a few trial vectors, such as Krylov, Nesbet, or Møller–Plesset correction vectors. In this space, Hamiltonian matrix elements may be directly computed in the many‐body fashion, as weighted sums of integral products over orbital indices. The variation‐perturbation method based on the first‐order wave function is equivalent to the Sup‐ CI method with a single correction vector of the Møller–Plesset type. Different points of view on the superdirect CI method are discussed and a version in which third‐order contributions are computed for a relatively small (10–100) space of reference and correction vectors is tested. Selection of the best “effective first‐order spaces” and size‐extensivity corrections in Sup‐ CI are briefly discussed. Møoller–Plesset, Epstein–Nesbet, and other correction vectors are included in the model calculations on the symmetric stretch of bonds in water, acetylene, and the NH 2 molecule. Errors are almost independent of molecular geometry and the method appears to be superior than the multireference second‐order perturbation methods. © 1994 John Wiley &amp; Sons, Inc.
A Geometrically Exact Continuum Framework for Light-Matter Interaction in Photo-Active Polymers I. Variational Setting (2020)

Molecular photo-switches as, e.g., azobenzene molecules allow, when embedded into a polymeric matrix, for photo-active polymer compounds responding mechanically when exposed to light of certain wavelength. Photo-mechanics, i.e. light-matter interaction in photo-active polymers holds great promise for, e.g., remote and contact-free activation of photo-driven actuators. In a series of earlier contributions, Oates et al. developed a successful continuum formulation for the coupled electric, electronic and mechanical problem capturing azobenzene polymer compounds, thereby mainly focussing on geometrically linearized kinematics. Building on that formulation, we here explore the variational setting of a geometrically exact continuum framework based on Dirichlet's and Hamilton's principle as well as, noteworthy, Hamilton's equations. Thereby, when treating the dissipative case, we resort to incremental versions of the various variational problems via suited incorporation of a dissipation potential. In particular, the Hamiltonian setting of geometrically exact photo-mechanics is up to now largely under-explored even for the energetic case, arguably since the corresponding Lagrangian is degenerate in Dirac's sense. Moreover, in general, the Hamiltonian setting of dissipative dynamical systems is a matter of ongoing debate per se. In this contribution, by advocating a novel incremental version of the Hamiltonian setting exemplified for the dissipative case of photo-mechanics, we aim to also unify the variational approach to dissipative dynamical systems. Taken together, the variational setting of a geometrically exact continuum framework of photo-mechanics paves the way for forthcoming theoretical and numerical analyses.
Abstract 188: Arterial Oxygen Saturation May Be the Limiting Factor for O2 Delivery During Compression-Only CPR (2011)

Background Previous studies show that there is no difference in outcomes between bystander conventional and chest-compression-only (CCO) CPR. However, several points need to be addressed: 1) the eq...
Change in functional status among children treated in the intensive care unit after injury (2018)

Prognostic/Epidemiologic, level III.
Image Quality Assessment Based on Multiscale Geometric Analysis (2009)

Reduced-reference (RR) image quality assessment (IQA) has been recognized as an effective and efficient way to predict the visual quality of distorted images. The current standard is the wavelet-domain natural image statistics model (WNISM), which applies the Kullback-Leibler divergence between the marginal distributions of wavelet coefficients of the reference and distorted images to measure the image distortion. However, WNISM fails to consider the statistical correlations of wavelet coefficients in different subbands and the visual response characteristics of the mammalian cortical simple cells. In addition, wavelet transforms are optimal greedy approximations to extract singularity structures, so they fail to explicitly extract the image geometric information, e.g., lines and curves. Finally, wavelet coefficients are dense for smooth image edge contours. In this paper, to target the aforementioned problems in IQA, we develop a novel framework for IQA to mimic the human visual system (HVS) by incorporating the merits from multiscale geometric analysis (MGA), contrast sensitivity function (CSF), and the Weber's law of just noticeable difference (JND). In the proposed framework, MGA is utilized to decompose images and then extract features to mimic the multichannel structure of HVS. Additionally, MGA offers a series of transforms including wavelet, curvelet, bandelet, contourlet, wavelet-based contourlet transform (WBCT), and hybrid wavelets and directional filter banks (HWD), and different transforms capture different types of image geometric information. CSF is applied to weight coefficients obtained by MGA to simulate the appearance of images to observers by taking into account many of the nonlinearities inherent in HVS. JND is finally introduced to produce a noticeable variation in sensory experience. Thorough empirical studies are carried out upon the LIVE database against subjective mean opinion score (MOS) and demonstrate that 1) the proposed framework has good consistency with subjective perception values and the objective assessment results can well reflect the visual quality of images, 2) different transforms in MGA under the new framework perform better than the standard WNISM and some of them even perform better than the standard full-reference IQA model, i.e., the mean structural similarity index, and 3) HWD performs best among all transforms in MGA under the framework.
Expanding the Scope of Noninvasive Prenatal Testing (2015)

Obstet Gynecol Surv 2015;70(8):481–482 There are noninvasive prenatal testing (NIPT) approaches using cell-free DNA in the maternal circulation to detect those women at high risk of trisomy 21, trisomy 18, trisomy 13, and sex chromosomal abnormalities. This study estimates the success of a single-nucleotide polymorphism (SNP) approach to analyzing maternal cell-free DNA in detecting 5 fetal microdeletion syndromes.
Evaluation of Rainfall Forecasts by Three Mesoscale Models during the Mei-Yu Season of 2008 in Taiwan. Part III: Application of an Object-Oriented Verification Method (2020)

In this study, the performances of Mei-yu (May–June) quantitative precipitation forecasts (QPFs) in Taiwan by three mesoscale models: the Cloud-Resolving Storm Simulator (CReSS), the Central Weather Bureau (CWB) Weather Research and Forecasting (WRF), and the CWB Non-hydrostatic Forecast System (NFS) are explored and compared using an newly-developed object-oriented verification method, with particular focus on the various properties or attributes of rainfall objects identified. Against a merged dataset from ~400 rain gauges in Taiwan and the Tropical Rainfall Measuring Mission (TRMM) data in the 2008 season, the object-based analysis is carried out to complement the subjective analysis in a parallel study. The Mei-yu QPF skill is seen to vary with different aspects of rainfall objects among the three models. The CReSS model has a total rainfall production closest to the observation but a large number of smaller objects, resulting in more frequent and concentrated rainfall. In contrast, both WRF and NFS tend to under-forecast the number of objects and total rainfall, but with a higher proportion of bigger objects. Location errors inferred from object centroid locations appear in all three models, as CReSS, NFS, and WRF exhibit a tendency to simulate objects slightly south, east, and northwest with respect to the observation. Most rainfall objects are aligned close to an E–W direction in CReSS, in best agreement with the observation, but many towards the NE–SW direction in both WRF and NFS. For each model, the objects are matched with the observed ones, and the results of the matched pairs are also discussed. Overall, though preliminarily, the CReSS model, with a finer grid size, emerges as best performing model for Mei-yu QPFs.
Blood pressure and hypertension in relation to lead exposure updated according to present-day blood lead levels (2023)

Lead is an environmental hazard that should be addressed worldwide. Over time, human exposure to lead in the Western world has fallen drastically to the levels comparable to those in humans living in the pre-industrial era, who were mainly exposed to natural sources of lead. To re-evaluate the health risks possibly associated with present-day lead exposure, a three-pronged approach was applied. First, we critically assessed the recently published population metrics describing the adverse health effects associated with lead exposure at the population level. Next, we summarized the key results of the Study for Promotion of Health in Recycling Lead (SPHERL; NCT02243904) and analyzed these results in the context of the published population metrics. Last but not least, we performed a brief literature review on the present-day lead exposure level in Poland. To our best knowledge, SPHERL is the first prospective study that accounted for interindividual variation in vulnerability to the toxic effects of lead exposure by assessing the participants' health status before and after occupational lead exposure, with blood pressure and hypertension as the primary outcomes. The overall conclusion of this comprehensive review on blood pressure and hypertension is that mainstream ideas about the public and occupational health risks related to lead exposure need to be urgently updated because a large part of the available literature has become obsolete given present-day exposure levels that sharply declined over the past 40 years.
Development of a radiolabeled caninized anti-EGFR antibody for comparative oncology trials (2017)

Due to large homology of human and canine EGFR, dogs suffering from spontaneous EGFR+ cancer can be considered as ideal translational models. Thereby, novel immunotherapeutic compounds can be developed for both human and veterinary patients. This study describes the radiolabeling of a canine anti-EGFR IgG antibody (can225IgG) with potential diagnostic and therapeutic value in comparative clinical settings. Can225IgG was functionalized with DTPA for subsequent chelation with the radionuclide <sup>99m</sup>Tc. Successful coupling of 10 DTPA molecules per antibody on average was proven by significant mass increase in MALDI-TOF spectroscopy, gel electrophoresis and immunoblots. Following functionalization and radiolabeling, <sup>99m</sup>Tc-DTPA-can225IgG fully retained its binding capacity towards human and canine EGFR in flow cytometry, immuno- and radioblots, and autoradiography. The affinity of radiolabeled can225IgG was determined to K<sub>D</sub> 0.8 ±0.0031 nM in a real-time kinetics assay on canine carcinoma cells by a competition binding technique. Stability tests of the radiolabeled compound identified TRIS buffered saline as the ideal formulation for short-term storage with 87.11 ±6.04% intact compound being still detected 60 minutes post radiolabeling. High stability, specificity and EGFR binding affinity pinpoint towards <sup>99m</sup>Tc-radiolabeled can225IgG antibody as an ideal lead compound for the first proof-of-concept diagnostic and therapeutic applications in canine cancer patients.
Air-pulse OCE for assessment of age-related changes in mouse corneain vivo (2014)

We demonstrate the use of phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to assess the relaxation rate of deformation created by a focused air-pulse in tissue-mimicking gelatin phantoms of various concentrations and mouse corneas of different ages in vivo. The results show that the relaxation rate can be quantified and is different for gels with varying concentrations of gelatin and mouse corneas of different ages. The results indicate that gel phantoms with higher concentrations of gelatin as well as older mouse corneas have faster relaxation rates indicating stiffer material. This non-contact and non-invasive measurement technique utilizes low surface displacement amplitude (in µm scale) for tissue excitation and, therefore, can be potentially used to study the biomechanical properties of ocular and other sensitive tissues.
ACCRETION DISKS WITH A LARGE SCALE MAGNETIC FIELD AROUND BLACK HOLES (2013)

We consider accretion disks around black holes at high luminosity, and the problem of the formation of a large-scale magnetic field in such disks, taking into account the non-uniform vertical structure of the disk. The structure of advective accretion disks is investigated, and conditions for the formation of optically thin regions in central parts of the accretion disk are found. The high electrical conductivity of the outer layers of the disk prevents outward diffusion of the magnetic field. This implies a stationary state with a strong magnetic field in the inner parts of the accretion disk close to the black hole, and zero radial velocity at the surface of the disk. The problem of jet collimation by magneto-torsion oscillations is investigated.
Comparison of the Indications and Treatment Results of Burr-Hole Drainage at the Maximal Thickness Area versus Twist-Drill Craniostomy at the Pre-Coronal Point for the Evacuation of Symptomatic Chronic Subdural Hematomas (2014)

Both BHD at the maximal thickness area and TDC at the pre-coronal point are safe and effective drainage methods for symptomatic CSDHs with reasonable indications.
Oxidative Degradation of Benzene Rings (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38α (2009)

Small molecule kinase inhibitors are an attractive means to modulate kinase activities in medicinal chemistry and chemical biology research. In the physiological setting of a cell, kinase function is orchestrated by a plethora of regulatory processes involving the structural transition of kinases between inactive and enzymatically competent conformations and vice versa. The development of novel kinase inhibitors is mainly fostered by high-throughput screening initiatives where the small molecule perturbation of the phosphorylation reaction is measured to identify inhibitors. Such setups require enzymatically active kinase preparations and present a risk of solely identifying classical ATP-competitive Type I inhibitors. Here we report the high-throughput screening of a library of approximately 35000 small organic molecules with an assay system that utilizes enzymatically inactive human p38alpha MAP kinase to detect stabilizers of the pharmacologically more desirable DFG-out conformation. We used protein X-ray crystallography to characterize the binding mode of hit compounds and reveal structural features which explain how these ligands stabilize and/or induce the DFG-out conformation. Lastly, we show that although some of the hit compounds were confirmed by protein X-ray crystallography, they were not detected in classic phosphorylation assays, thus validating the unique sensitivity of the assay system used in this study and highlighting the potential of screening with inactive kinase preparations.
In-situ Transmission Electron Microscopy Studies of Ion Irradia8on Effects in Au Nanorods and Si Nanowires. (2014)

Abstract not provided.