gebhart/patrepeval huggingface dataset:
On the null space in linearized anisotropic crosswell traveltime tomography (1996)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1996On the null space in linearized anisotropic crosswell traveltime tomographyAuthors: Kenneth P. BubeMark A. MeadowsKenneth P. BubeUniversity of Washington and Mark A. MeadowsChevron Petroleum Technology Co.https://doi.org/10.1190/1.1826566 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1826566FiguresReferencesRelatedDetailsCited ByOn resolution and uniqueness in anisotropic crosshole traveltime tomographyPaul R. Williamson7 February 2012 | GEOPHYSICS, Vol. 63, No. 4 SEG Technical Program Expanded Abstracts 1996ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1996 Pages: 2106 publication data© 1996 Copyright © 1996 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Kenneth P. Bube and Mark A. Meadows, (1996), "On the null space in linearized anisotropic crosswell traveltime tomography," SEG Technical Program Expanded Abstracts : 2027-2030. https://doi.org/10.1190/1.1826566 Plain-Language Summary PDF DownloadLoading ...
A Gelatin Coated Collagen-Polyglycolic Acid Composite Membrane as a Dural Substitute (2001)

We designed a new biodegradable composite membrane for use as a dural substitute. This membrane is composed of polyglycolic acid (PGA) mesh, collagen sponge, and gelatin sponge. Collagen layers are attached on both sides of the PGA mesh. One side of the membrane is coated with freeze-dried gelatin to prevent tissue adhesion. We examined the mechanical properties of the membrane and evaluated its efficacy in vivo by implanting it into dogs. When the mechanical properties of the membrane were measured under wet conditions, tensile strength and resistance against cutting by a suture were approximately 20 N/cm and 13 N, respectively, which are adequate for a surgical material. In the in vivo experiment, our dural substitute was implanted into six adult beagle dogs to repair a 25 x 15 mm defect in the dura mater. Two dogs each were killed at 2 and 4 months after implantation and two were observed over 6 months. At 4 months after implantation, the implanted dural substitute was almost absorbed and a fibrous membrane resembling native host dura had regenerated at the site. No foreign body reaction or significant adhesion to the cerebral cortex was observed. These results indicate the clinical potential of our novel dural substitute.
A Reversibly Induced CRISPRi System Targeting Photosystem II in the Cyanobacterium Synechocystis sp. PCC 6803 (2020)

The cyanobacterium <i>Synechocystis</i> sp. PCC 6803 is used as a model organism to study photosynthesis, as it can utilize glucose as the sole carbon source to support its growth under heterotrophic conditions. CRISPR interference (CRISPRi) has been widely applied to repress the transcription of genes in a targeted manner in cyanobacteria. However, a robust and reversible induced CRISPRi system has not been explored in <i>Synechocystis</i> 6803 to knock down and recover the expression of a targeted gene. In this study, we built a tightly controlled chimeric promoter, P<sub> <i>rhaBAD</i>-RSW</sub>, in which a theophylline responsive riboswitch was integrated into a rhamnose-inducible promoter system. We applied this promoter to drive the expression of ddCpf1 (DNase-dead Cpf1 nuclease) in a CRISPRi system and chose the PSII reaction center gene <i>psbD</i> (D2 protein) to target for repression. <i>psbD</i> was specifically knocked down by over 95% of its native expression, leading to severely inhibited photosystem II activity and growth of <i>Synechocystis</i> 6803 under photoautotrophic conditions. Significantly, removal of the inducers rhamnose and theophylline reversed repression by CRISPRi. Expression of PsbD recovered following release of repression, coupled with increased photosystem II content and activity. This reversibly induced CRISPRi system in <i>Synechocystis</i> 6803 represents a new strategy for study of the biogenesis of photosynthetic complexes in cyanobacteria.
Sub-domain Modelling for Dialogue Management with Hierarchical Reinforcement Learning (2017)

Paweł Budzianowski, Stefan Ultes, Pei-Hao Su, Nikola Mrkšić, Tsung-Hsien Wen, Iñigo Casanueva, Lina M. Rojas-Barahona, Milica Gašić. Proceedings of the 18th Annual SIGdial Meeting on Discourse and Dialogue. 2017.
Eliminating primers from completed polymerase chain reactions with exonuclease VII (1991)

Single-stranded oligonucleotide primers can be efficiently removed after PCR using E.coli exonuclease VII. Even only a few molecules of double stranded PCR product are unaffected by a treatment which eliminates 20 picomoles of primer in the presence of 500 ng of denatured genomic DNA. Exonuclease VII treatment is rapid and could simplify complicated multistep PCR protocols.
Extending Unification Formalisms (1995)

This paper describes some of the results of the project The Reusability of Grammatical Resources. The aim of the project is to extend current grammar formalisms with notational devices and constraint solvers in order to aid the development of reusable grammars. The project took the Advanced Lin-guistic Engineering Platform (ALEP) as its starting point. ALEP allows two levels of extension: addi-tional syntactic expressions (“syntactic sugar”) and specialised external constraint solvers. Our syntac-tic additions to ALEP comprise support for LFG co-herence and completeness and an extended notation for phrase-structure rules. The project has devel-oped solvers for set constraints, set operations, lin-ear precedence constraints and guarded constraints. The extensions were formally specified and imple-mented as Prolog modules and hence have a wider applicability. These can be either used standalone or integrated within existing grammar formalisms. We have sucessfully integrated the all constraint solvers with the ProFIT typed feature system and these have been partially integrated into ALEP. 1
Electrophysiological Correlates of a Conditioned Response in Cats (1956)

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New CP Criteria for Elimination of the Risks of AC Corrosion and Overprotection on Cathodically Protected Pipelines (2002)

Abstract The risks of AC corrosion and overprotection are increasing on cathodically protected buried steel pipelines, due to the increased cases of installing pipelines in proximity to high voltage AC power transmission lines and DC/AC powered rail transit systems. Based on field and laboratory studies as well as literature research, new cathodic protection (CP) criteria were developed based on AC and DC current densities measured using coupons, to eliminate those risks. Using these criteria, the design of CP systems for newly constructed pipelines, paralleling overhead high voltage AC power transmission lines, and in the proximity to DC powered rail transit systems, was successfully performed. Corrective measures to eliminate the risk of AC corrosion were taken by the use of distributed magnesium anodes and solid-state DC decoupling devices.
Sign-tunable anomalous Hall effect induced by two-dimensional symmetry-protected nodal structures in ferromagnetic perovskite oxide thin films (2019)

Magnetism and spin-orbit coupling (SOC) are two quintessential ingredients underlying novel topological transport phenomena in itinerant ferromagnets. When spin-polarized bands support nodal points/lines with band degeneracy that can be lifted by SOC, the nodal structures become a source of Berry curvature; this leads to a large anomalous Hall effect (AHE). Contrary to three-dimensional systems that naturally host nodal points/lines, two-dimensional (2D) systems can possess stable nodal structures only when proper crystalline symmetry exists. Here we show that 2D spin-polarized band structures of perovskite oxides generally support symmetry-protected nodal lines and points that govern both the sign and the magnitude of the AHE. To demonstrate this, we performed angle-resolved photoemission studies of ultrathin films of SrRuO$_3$, a representative metallic ferromagnet with SOC. We show that the sign-changing AHE upon variation in the film thickness, magnetization, and chemical potential can be well explained by theoretical models. Our study is the first to directly characterize the topological band structure of 2D spin-polarized bands and the corresponding AHE, which could facilitate new switchable devices based on ferromagnetic ultrathin films.
Promptagator: Few-shot Dense Retrieval From 8 Examples (2022)

Much recent research on information retrieval has focused on how to transfer from one task (typically with abundant supervised data) to various other tasks where supervision is limited, with the implicit assumption that it is possible to generalize from one task to all the rest. However, this overlooks the fact that there are many diverse and unique retrieval tasks, each targeting different search intents, queries, and search domains. In this paper, we suggest to work on Few-shot Dense Retrieval, a setting where each task comes with a short description and a few examples. To amplify the power of a few examples, we propose Prompt-base Query Generation for Retriever (Promptagator), which leverages large language models (LLM) as a few-shot query generator, and creates task-specific retrievers based on the generated data. Powered by LLM's generalization ability, Promptagator makes it possible to create task-specific end-to-end retrievers solely based on a few examples {without} using Natural Questions or MS MARCO to train %question generators or dual encoders. Surprisingly, LLM prompting with no more than 8 examples allows dual encoders to outperform heavily engineered models trained on MS MARCO like ColBERT v2 by more than 1.2 nDCG on average on 11 retrieval sets. Further training standard-size re-rankers using the same generated data yields another 5.0 point nDCG improvement. Our studies determine that query generation can be far more effective than previously observed, especially when a small amount of task-specific knowledge is given.
Effect of thermal aging on the mechanical characteristics of a composite of a polyimide with an organosilicon resin (2011)

The effect exerted by thermal aging in air at 350°C on the thermal and mechanical properties of composite films prepared on the basis of heat-resistant polyimide PM and non-film-forming polymethylphenylsiloxane (PMPS) was examined. The phase segregation of polymeric composites of various compositions and the thermal aging rate were evaluated.
Ureteral Stents: Materials (1989)

No AccessJournal of Urology1 May 1989Ureteral Stents: Materials H.K. Mardis and R.M. Kroeger H.K. MardisH.K. Mardis and R.M. KroegerR.M. Kroeger View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)41280-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Ureteral Stents: Materials." The Journal of Urology, 141(5), p. 1278 © 1989 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 141Issue 5May 1989Page: 1278 Advertisement Copyright & Permissions© 1989 by The American Urological Association Education and Research, Inc.Metrics Author Information H.K. Mardis More articles by this author R.M. Kroeger More articles by this author Expand All Advertisement PDF downloadLoading ...
Analysis of Tandem Mass Spectra by FTMS for Improved Large-Scale Proteomics with Superior Protein Quantification (2009)

Using a newly developed dual-cell quadrupole linear ion trap-orbitrap hybrid mass spectrometer (dcQLT-orbitrap), we demonstrate the utility of collecting high-resolution tandem mass spectral data for large-scale shotgun proteomics. Multiple nanoLC-MS/MS experiments on both an older generation quadrupole linear ion trap-orbitrap hybrid (QLT-orbitrap) and the dcQLT-orbitrap, using both resonant-excitation CAD and beam-type CAD (HCD), were performed. Resulting from various technological advances (e.g., a stacked ring ion guide AP inlet, a dual cell QLT), the dcQLT-orbitrap exhibited increased duty cycle (approximately 1.5-2 times) and sensitivity for both CAD (ion trap detection) and HCD (orbitrap detection) methods. As compared to the older system, the dcQLT-orbitrap produced significantly more unique peptide identifications for both methods (approximately 30% improvement for CAD and approximately 115% improvement for HCD). The sizable improvement of the HCD method on the dcQLT-orbitrap system outperforms the current standard method of CAD with ion trap detection for large-scale analysis. Finally, we demonstrate that the increased HCD performance translates to a direct and substantial improvement in protein quantitation precision using isobaric tags.
Resisting Sybil Attack By Social Network and Network Clustering (2010)

Peer to peer (P2P) systems are extremely vulnerable to Sybil attacks, in which a malicious user controls a large number of Sybil peers to collude to break the system laws. This paper proposes a distributed algorithm, named Sybil Resisting Network Clustering (SRNC), to resist the Sybil attack by preventing honest peers from communicating with Sybil Peers. SRNC is based on a social network model. In this model, honest peers and Sybil peers can be largely classified into two clusters, connected by a small number of edges, called attack edges. SRNC tries to explicitly detect attack edges, and then prohibits the communication over the detected edges. The performance of SRNC is evaluated by theoretical analysis and simulations. In particular, SRNC ensures theoretically that honest peers totally accept O(|AE|) Sybil peers. This is a O(log(n)) times improvement over SybilLimit, one of the conventional representative Sybil resisting algorithms, where n is the number of peers and |AE| is the number of attack edges in the system. The performance is then evaluated by simulations on data sets of real world social networks.
Health Outcomes and Costs of Rituximab in Combination with Cyclophosphamide, Vincristine and Prednisolone in the Treatment of Patients with Advanced Follicular Lymphoma in Portugal. (2009)

Abstract Abstract 2481 Poster Board II-458 Objective: With the pressure on healthcare budgets, it has become increasingly important for healthcare decision makers to consider the value for money of the treatments they reimburse. The objective of this analysis was to evaluate the long term outcomes and costs of rituximab in combination with cyclophosphamide/vincristine/prednisolone chemotherapy regimen (R-CVP) versus CVP alone, in previously untreated patients with indolent Non-Hodgkin Lymphoma (NHL) from the Portuguese National Health System (NHS) perspective. Methods: Cost-effectiveness (Life Years Gained - LYG) and cost-utility analysis (Quality Adjusted Life years – QALYs) were performed for a time horizon of 10 years, according to a Markov economic model with three health states (“progression free survival”, “progression” and “death”) and monthly cycles for a population of previously untreated patients with indolent NHL. Data from a phase III clinical trial (Marcus 2007) was used and expanded to include unpublished 53-month median follow-up data. Survival after first-line therapy was estimated from the Scotland and Newcastle Lymphoma Group registry data and utilities were derived from a study in the UK performed in patients with follicular lymphoma. Resource consumption was estimated by a Portuguese expert panel (Delbecq Panel). Costs were calculated from the Portuguese NHS perspective through official data with prices updated to 2008. Only direct medical costs were considered. Costs and clinical outcomes were discounted at 5% per annum. Deterministic and probabilistic sensitivity analysis were performed around assumptions on the time horizon, costs, utilities and excess mortality rate due to progression applied in the base-case analysis. Results: The 10-year base-case analysis showed a lower total cost per patient with CVP alone (€ 85,838) in comparison with R-CVP (€ 87,774). Life expectancy and quality-adjusted life expectancy per patient were higher with R-CVP (6.361 and 4.166, respectively) than with CVP alone (5.557 and 3.438, respectively), representing increases of 0.804 in LYG and 0.728 (8.7 months) in QALYs gained. The incremental cost per LYG was € 2,407 and the incremental cost per QALY gained was € 2,661. The probabilistic sensitivity analysis confirmed the robustness of the base-case analysis results. Conclusions: This study demonstrates that the combination R-CVP in previously untreated non-Hodgkin lymphoma patients improves life expectancy and is a cost-effective alternative to CVP in Portugal. Disclosures: Braga: Roche Farmacêutica Química, Lda: Employment. Pereira:Roche Farmacêutica Química, Lda.: Employment.
ChemInform Abstract: STUDIES ON 8BETA‐SUBSTITUTED STEROIDS PART 1‐4 (SYNTHESIS OF 8BETA‐SUBSTITUTED STEROIDS, X‐RAY ANALYSIS OF 8BETA‐METHYLATED STEROIDS, HORMONAL AND ANTIHORMONAL ACTIVITIES OF 8BETA‐SUBSTITUTED STEROIDS, EFFECT OF HYDROCORTISONE 8BETA‐CARBOXYLIC ACID 8,11BETA‐LACTONE ON PITUITARY‐ADRENAL AXIS OF RATS) (1974)

Abstract In der ersten von vier aufeinanderfolgenden Arbeiten werden Synthesemöglichkeiten für 8ß‐substituierte Steroide beschrieben.
Multifunction array lidar network for intruder detection, tracking, and identification (2010)

This paper describes a novel lidar sensor network based on a small, flat, optical phase array laser aperture. The network of array lidars provides collaborative automatic detection, tracking, acquisition cueing, and intruder type identification, as well as free space optics communication. The lidar consists of four optical phased arrays, each with about 1 million radiating elements in a 1-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> aperture that enable electronic beam steering analogous to microwave array antennas. The four arrays are mounted on four sides of a stalk and have a full 360° field of view. A small number of such stalks can perform target detection over a large area.
Dufour’s gland analysis reveals caste and physiology specific signals in Bombus impatiens (2021)

Reproductive division of labor in insect societies is regulated through multiple concurrent mechanisms, primarily chemical and behavioral. Here, we examined if the Dufour's gland secretion in the primitively eusocial bumble bee Bombus impatiens signals information about caste, social condition, and reproductive status. We chemically analyzed Dufour's gland contents across castes, age groups, social and reproductive conditions, and examined worker behavioral and antennal responses to gland extracts. We found that workers and queens each possess caste-specific compounds in their Dufour's glands. Queens and gynes differed from workers based on the presence of diterpene compounds which were absent in workers, whereas four esters were exclusive to workers. These esters, as well as the total amounts of hydrocarbons in the gland, provided a separation between castes and also between fertile and sterile workers. Olfactometer bioassays demonstrated attraction of workers to Dufour's gland extracts that did not represent a reproductive conflict, while electroantennogram recordings showed higher overall antennal sensitivity in queenless workers. Our results demonstrate that compounds in the Dufour's gland act as caste- and physiology-specific signals and are used by workers to discriminate between workers of different social and reproductive status.
Self-Assembly of Genetically Engineered Spider Silk Block Copolymers (2009)

The design, construction, and preliminary characterization of a novel family of spider silk-like block copolymers are described. The design was based on the assembly of individual spider silk modules, in particular, polyalanine (A) and glycine-rich (B) blocks, that display different phase behavior in aqueous solution. Spider silk was chosen as a model for these block copolymer studies based on its extraordinary material properties, such as toughness, biocompatibility, and biodegradability. Trends in spider silk-like block copolymer secondary structure and assembly behavior into specific material morphologies were determined as a function of the number of hydrophobic blocks, the presence of a hydrophilic purification tag and solvent effects. Structures and morphologies were assessed by Fourier transform infrared spectroscopy and scanning electron microscopy. In terms of structure, beta-sheet content increased with an increase in the number of polyalanine blocks, and the purification tag had significant impact on the secondary structure. In terms of morphology, spheres, rod-like structures, bowl-shaped micelles, and giant compound micelles were observed and the morphologies were linked with the size of the hydrophobic block, the presence of the purification tag, and the solvent environment. This study provides a basis for future designs of smart biomaterials based on spider silk chemistries, with controlled structure-architecture-function relationships.
Preexposure Rabies Vaccination (1994)

Preexposure rabies vaccination consists of the provision of protective antibodies to individuals who are potentially at risk of being infected with rabies.' This is done by giving three primary injections of a tissue culture rabies vaccine one each on day 0,7, and 28 (a few days variation in timing is acceptable). The vaccine is administered either as a full dose (usually 1 mL) intramuscularly or 0.1 mL intradermally. Intramuscular injections are given into the deltoid region (or lateral thigh muscle in small children).' Human diploid cell rabies vaccine (HDCV) and rhesus monkey diploid fetal lung cell vaccines (Michigan State Laboratory) are currently the products available in North America. Other tissue culture vaccines of proven quality are marketed abroad, and several are now being considered for approval in America. They are Purified Vero Cell Rabies Vaccine (PVRV) made by the Merieux Co in France, Purified Duck Embryo Vaccine (PDEV) made by the Swiss Serum and Vaccine Institute (not t o be confused with the poorly immunogenic old Duck Embryo Vaccines), and Purified Chick Embryo Rabies Vaccine (PCEC) made by Behring in Germany and the Chemo-Sero Institute in Japan. East European and Chinese firms manufacture tissue culture vaccines grown in baby hamster cells, but there is little independent literature in peer review journals attesting to their consistent quality control and immunogenicity. Many countries still manufacture and use central nervous tissue-derived rabies vaccines such as Semple and suckling mouse brain products. Most of these are of uncertain immunogenicity and carry a risk of severe adverse neurologic reaction^.^,^ Brain tissue-derived rabies vaccines are not to be used for preexposure vaccination due to an unacceptably poor risubenefit ratio.',