gebhart/patrepeval huggingface dataset:
Narrative in Virtual Environments - Towards Emergent Narrative (1999)

In this paper we consider the clash between the pre-scripted character of much narrative and the freedom afforded by a Virtual Environment. We discuss the concept of emergent narrative as a possible way of avoiding this clash. We examine the role of a VE user in a narrative and consider the concept of social presence as a means of reconciling the freedom of the user with the constraints of an emergent narrative.
An Isolated Nitridyl Radical‐Bridged {Rh(N.)Rh} Complex (2014)

Photochemical activation of [(PNNH)Rh(N3)] (PNNH = 6-di-(tert-butyl)phosphinomethyl-2,2'-bipyridine) complex 2 produced the paramagnetic (S = 1/2), [(PNN)Rh=N(·)-Rh(PNN)] complex 3 (PNN(-) = methylene-deprotonated PNNH), which could be crystallographically characterized. Spectroscopic investigation of 3 indicates a predominant nitridyl radical ((·)N(2-)) character, which was confirmed computationally. Complex 3 reacts selectively with CO, producing two equivalents of [(PNN)Rh(I)(CO)] complex 4, presumably by nitridyl radical N,N-coupling.
Immunobiological Activity of Synthetically Prepared Immunodominant Galactomannosides Structurally Mimicking Aspergillus Galactomannan (2017)

The study is oriented at the <i>in vitro</i> evaluation of the immunobiological activity and efficacy of synthetically prepared isomeric pentasaccharides representing fragments of <i>Aspergillus fumigatus</i> cell-wall galactomannan and containing β-(1→5)-linked tetragalactofuranoside chain attached to O-6 (<b>GM-1</b>) or O-3 (<b>GM-2</b>) of a spacer-armed mannopyranoside residue. These compounds were studied as biotinylated conjugates which both demonstrated immunomodulatory activities on the RAW 264.7 cell line murine macrophages as <i>in vitro</i> innate immunity cell model. Immunobiological studies revealed time- and concentration-dependent efficient immunomodulation. The proliferation of RAW 264.7 macrophages was induced at higher concentration (100 µg/mL) of studied glycoconjugates and longer exposure (48 h), with more pronounced efficacy for <b>GM-1</b>. The increase of proliferation followed the previous increase of IL-2 production. The cytokine profile of the macrophages treated with the glycoconjugates was predominantly pro-inflammatory Th1 type with significant increase of TNFα, IL-6, and IL-12 release for both glycoconjugates. The RAW 264.7 macrophages production of free radicals was not significantly affected by glycoconjugates stimulation. The phagocytic activity of RAW 264.7 cells was reduced following <b>GM-1</b> treatment and was significantly increased after 24 h stimulation with <b>GM-2</b>, contrary to 48 h stimulation. Moreover, the synthetically prepared galactomannoside derivatives have been evaluated as efficient serodiagnostic antigens recognized by specific Ig isotypes, and significant presence of specific IgM antibodies in serum of patients suffering from vulvovaginitis was observed.
Corrosion of Pure iron and Hydrogen Permeation in the Presence of H 2 S with O 2 contamination (2018)

Congrès Corrosion Nace Phoenix (USA) 15-19 avril 2018
Microfibril-associated glycoprotein-1 (MAGP-1) is specifically located on the beads of the beaded-filament structure for fibrillin-containing microfibrils as visualized by the rotary shadowing technique. (1996)

This study used immunoelectron microscopic techniques to define the ultrastructural location of MAGP-1 on the fibrillin-containing microfibrils of the ocular zonule. A specific anti-MAGP-1 monoclonal antibody (MAb), 11B, was produced that did not crossreact with fibrillin-1 or other microfibrillar proteins. MAb 11B was shown by immunofluorescence to localize intensely to zonular tissue. Postembedding immunoelectron microscopy showed that MAGP-1 was associated with microfibrils throughout the zonule, with the exception of a narrow band of microfibrils at the junction with the lens capsule. With preembedding labeling, the anti-MAGP-1 MAb was found to localize in a crossbanding pattern, at intervals of about 50 nm, to microfibrils throughout the zonule and along bundles of microfibrils in surrounding vitreous tissue. Rotary shadowing of isolated microfibrils showed a "beads on a string" morphology with a periodicity of about 50 nm. With immunogold labeling, the anti-MAGP-1 antibody specifically localized on the beads in a symmetrical manner. Occasionally two gold partides were attached to the same bead, suggesting that multiple MAGP-1 molecules were present in the structure. The results indicate that MAGP-1 is intimately and regularly associated with the bead regions of fibrillin-containing microfibrils. The findings are consistent with a major structural role for MAGP-1 in microfibril biology.
Cytochrome c at charged interfaces. 2. Complexes with negatively charged macromolecular systems studied by resonance Raman spectroscopy (1989)

We have analyzed the structure of cytochrome c (cyt c) bound in a variety of complexes in which negatively charged molecular groups interact with the positively charged binding domain around the heme crevice of cyt c. Using resonance Raman spectroscopy, we could demonstrate that these interactions induce the same conformational changes as they were observed in the surface-enhanced resonance Raman experiments of cyt c adsorbed on the Ag electrode [Hildebrandt & Stockburger (1989) Biochemistry (preceding paper in this issue)]. When cyt c is bound to (As4W40O140)27-, state II is stabilized, whereas in complexes with phosvitin and cytochrome b5 state I is formed. The complexes with phospholipid vesicles and inverted micelles reveal a mixture of both states. It is suggested that these systems as well as cyt c adsorbed on the Ag electrode may be regarded as model systems for the physiological complexes of cyt c with cytochrome oxidase and cytochrome reductase. On the basis of our findings it is proposed that the biological electron-transfer reactions are controlled by electric field induced conformational transitions of cyt c upon complex formation with its physiological redox partners.
Enhanced Photoluminescence of Solution-Exfoliated Transition Metal Dichalcogenides by Laser Etching (2017)

Using a conventional Raman experimental apparatus, we demonstrate that the photoluminescent (PL) yield from ultrasonication-exfoliated transition metal dichalcogenides (TMDs) (MoS<sub>2</sub> and WS<sub>2</sub>) can be increased by up to 8-fold by means of a laser etching procedure. This laser etching process allows us to controllably pattern and reduce the number of layers of the solution-exfoliated material, overcoming the key drawback to solvent-based exfoliation of two-dimensional (2D) semiconducting materials for applications in optoelectronics. The successful laser thinning of the exfoliated 2D crystals was investigated systematically by changes in both Raman and PL spectra. A simple proof-of-principle of the scalability of this laser etching technique for solution-exfoliated TMD crystals was also demonstrated. As well as being applicable for individual materials, it is also possible to use this simple laser etching technique to investigate the structure of solution-generated van der Waals heterostructures, consisting of layers of both MoS<sub>2</sub> and WS<sub>2</sub>.
Comparison of Step‐Down and Binary Search Algorithms for Determination of Defibrillation Threshold in Humans (2004)

Determination of DFT is an integral part of ICD implantation. Two commonly used methods of DFT determination, the step-down method and the binary search method, were compared in 44 patients undergoing ICD testing for standard clinical indications. The step-down protocol used an initial shock of 18 J. The binary search method began with a shock energy of 9 J and successive shock energies were increased or decreased depending on the success of the previous shock. The DFT was defined as the lowest energy that successfully terminated ventricular fibrillation. The binary search method has the advantage of requiring a predetermined number of shocks, but some have questioned its accuracy. The study found that (mean) DFT obtained by the step-down method was 8.2 +/- 5.0, whereas by the binary search method DFT was 8.1 +/- 0.7 J, P = NS. DFT differed by no more than one step between methods in 32 (71%) of patients. The number of shocks required to determine DFT by the step-down method was 4.6 +/- 1.4, whereas by definition, the binary search method always required three shocks. In conclusion, the binary search method is preferable because it is of comparable efficacy and requires fewer shocks.
Silent chromatin in yeast: an orchestrated medley featuring Sir3p (1998)

The title for the review article published in BioEssays 20:30–40 should read ‘Silent chromatin in yeast: an orchestrated medley featuring Sir3p’. Please note corrections for Figure 3 as follows The publisher regrets these errors. © 1998 John Wiley & Sons, Inc.
Quantum Algorithm Providing Exponential Speed Increase for Finding Eigenvalues and Eigenvectors (1999)

We describe a new polynomial time quantum algorithm that uses the quantum fast Fourier transform to find eigenvalues and eigenvectors of a local Hamiltonian, and that can be applied in cases (commonly found in ab initio physics and chemistry problems) for which all known classical algorithms require exponential time. Applications of the algorithm to specific problems are considered, and we find that classically intractable and interesting problems from atomic physics may be solved with between 50 and 100 quantum bits.
Reading Disability: Developmental Dyslexia. (1967)

"Reading disability" is defined as the inability of an individual to acquire skill in reading and spelling that is commensurate with his general level of intelligence. This book is a general summary of specific language difficulties. The references, over 400 in number, range in date from 1885 to 1965. The problem is extraordinarily complex. Causative and related factors extend well into the fields of neurology, psychology, genetics, environment, and pedagogy. The roots of the disorder do not originate in any dysfunction of the eyes as visual organs, but it is to the ophthalmologists that parents and teachers are likely to turn first when reading disability becomes evident. The ophthalmologist should have little difficulty in recognizing the disorder. The child—usually a boy—reads at a level below the norm for his age. He confuses small words which resemble each other in configuration (in, on, an, etc) and orients poorly such printed letters
Pressure characterization and resolution limits' investigation of high accuracy NDIR Methane sensor for environmental applications (2017)

Pressure characterization and resolution limits' investigation of high accuracy NDIR Methane sensor for environmental applications
Perioperative management and Fast-Track therapy in vascular medicine (2011)

Perioperative risk in vascular medicine is particularly high due to the increased prevalence of cardiovascular comorbidity. Therefore, it is of the utmost importance that during periprocedural management the patient remains in good general condition and that the patient is mobilized as soon as possible. Along with implementation of minimally-invasive techniques and endovascular procedures, networking and cooperation between the surgeon, anesthesiologist, physiotherapist and the nursing team can lead to an optimization of perioperative mobilization. The Fast-Track concept represents uncharted territory in the field of vascular surgery and it can provide advantages, particularly in relation to multimorbidity in the field of vascular medicine. The Fast-Track concept was introduced by Danish surgeon Henrik Kehlet and was originally intended to be implemented in general surgery. When compared to conventional management, this method offers better medical results, lower costs and other advantages for the patient: besides a better perioperative condition a reduction of postoperative complications and reduction of overall in-hospital stay was achieved. Therefore, the next logical step was to introduce and adapt this concept to other fields of operative medicine. This paper represents a systematic review on the actual experience of the fast-track concept in vascular surgery.
A lightweight linear actuator with concentratedly placed stationary coils (2005)

This paper presents a novel lightweight linear actuator using permanent magnets and having its coils on the stator concentratedly. The rated force is 6 N, the stroke is 30 mm, and the weight is below 300 g owing to its unique structure. The machine is to be applied to, e.g., a pick-and-place actuator of tiny electronic parts, and the performance for the application is confirmed through experiments with a prototype. © 2005 Wiley Periodicals, Inc. Electr Eng Jpn, 153(4): 59–67, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20158
Tactile feedback to the palm using arbitrarily shaped DEA (2014)

Tactile stimulation enhances user experience and efficiency in human machine interaction by providing information via another sensory channel to the human brain. DEA as tactile interfaces have been in the focus of research in recent years. Examples are (vibro-) tactile keyboards or Braille displays. These applications of DEA focus mainly on interfacing with the user’s fingers or fingertips only – demonstrating the high spatial resolution achievable with DEA. Besides providing a high resolution, the flexibility of DEA also allows designing free form surfaces equipped with single actuators or actuator matrices which can be fitted to the surface of the human skin. The actuators can then be used to provide tactile stimuli to different areas of the body, not to the fingertips only. Utilizing and demonstrating this flexibility we designed a free form DEA pad shaped to fit into the inside of the human palm. This pad consists of four single actuators which can provide e.g. directional information such as left, right, up and down. To demonstrate the value of such free form actuators we manufactured a PC-mouse using 3d printing processes. The actuator pad is mounted on the back of the mouse, resting against the palm while operating it. Software on the PC allows control of the vibration patterns displayed by the actuators. This allows helping the user by raising attention to certain directions or by discriminating between different modes like “pick” or “manipulate”. Results of first tests of the device show an improved user experience while operating the PC mouse.
pH-dependent properties of SOD studied through mutants on Lys-136 (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTpH-dependent properties of SOD studied through mutants on Lys-136Lucia Banci, Ivano Bertini, Claudio Luchinat, and Maria Silvia ViezzoliCite this: Inorg. Chem. 1993, 32, 8, 1403–1406Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ic00060a014https://doi.org/10.1021/ic00060a014research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phase Ib study of plitidepsin (APL) with gemcitabine (GEM) in refractory solid tumors and lymphoma patients. (2012)

2539 Background: Combination chemotherapy (CT) regimens may improve the outcome of patients with advanced metastatic disease. APL (a marine-derived cyclodepsipeptide) is a cytotoxic agent that induces apoptosis by JNK-pathway activation and increased oxidative stress; it has also shown anti-angiogenic properties in vitro. GEM has a different mechanism of action and toxicity profile from APL, making this combination appropriate for clinical testing. Moreover, APL has been shown pre-clinically to potentiate the anti-tumor effect of GEM. Methods: Patients with ECOG-PS ≤ 1 received escalating doses of APL/GEM (1.8/750, 1.8/1000, 2.4/1000 and 3.0/1000 mg/m 2 ) on days 1, 8 and 15 every four weeks. The primary objective was to determine of the maximum tolerated dose (MTD) and the recommended dose (RD) for APL/GEM. Secondary objectives included characterization of safety profile, pharmacokinetics (PK) and anti-tumor activity of APL/GEM. Results: 34 patients were included and 33 treated (23 solid tumors and 11 lymphomas) with a median age of 59 years (r: 28–86), median prior CT lines 3 (r:1-7) and a median of 2 cycles (r:1-12). Relative dose intensity was 66.7% (r: 37.7-85.7%) and 80.9% (r: 56.1-100.6%) for APL and GEM, respectively. The MTD was 3.0/1000 mg/m 2 , as 2/6 patients experienced dose limiting toxicities (DLTs) [grade (G) 4 thrombocytopenia and 2 missed doses due to G2 ALT/AST]. The RD was 2.4/1000 mg/m 2 , with no patients experiencing DLTs. Adverse events (AEs) were mainly G 1-2 anemia, thrombocytopenia and ALT/AST increase. Six patients with solid tumors had stable disease (SD) ≥ 3 months, one patient with NK T-cell lymphoma had a complete response, a patient with Hodgkin disease (HD) had a partial response and three other patients with HD had SD ≥ 3 months with tumor decrease at the RD. No relevant drug-drug interaction was observed for the dose levels tested. Conclusions: APL/GEM at the RD can be safely combined. Objective responses were observed in patients with HD and NK T-Cell lymphoma. Further studies of this combination in lymphoma are warranted.
Some Aspects of the Chemistry of Nitro Compounds (2012)

Abstract The present brief account relates our discovery of new reactions revolving around the chemistry of the NO 2 group. It covers the condensation of MeNO 2 with hindered ketones, and the synthesis of pyrroles, triazoles, and enamides. It also describes new transformations of allylic nitro compounds, such as their conversion to allylic sulfones and unsaturated lactones, their sigmatropic rearrangement into allylic nitrites and thence into allylic alcohols, as well as their use in a short synthesis of nitroestrone derivatives. This is followed by an unusual reduction method furnishing unsubstituted amines (RR′CNH) under conditions where these hydrolytically labile species can be captured inter‐ or intramolecularly. Finally, a mechanistic study of a strange alkyne‐forming reaction, first reported by Abidi and later shown by Corey and co‐workers to proceed through allylic nitro intermediates, ultimately led to a practical and powerful synthesis of alkynes starting from β ‐keto esters.
Technological Choice In Voluntary Standards Committees: An Empirical Analysis (1990)

Vendors frequently compete to have their technology adopted as part of a voluntary consensus standard. In this paper we report the results of an empirical study of the factors that influence the choice of technologies in voluntary technical standards committees. Participation in standards committees is viewed as an aspect of the product development process of corporations involved in markets where network externalities are present. The factors hypothesized to affect the technology decision are: the market power of the coalition sponsoring the technology, the installed base of the products containing the technology, the size of the firms that make up the coalition, the promotional activities of the sponsors (such as technical contributions submitted), the perceived superiority of the technology, and the political skills of the coalition. These hypotheses were tested by collecting data concerning specific technical decisions that were made in several standards committees in the area of computer communications hardware. Two sided t-tests were used to test the hypotheses, and logit regression was used to infer the importance of each factor in predicting adoption or non-adoption of the technology. A factor analysis was also performed to gain further insight into the data. The results suggest that the size of the firms in the coalition supporting a technology and the extent to which they support their position through written contributions are significant determinants of technological choice in the standards decisions studied. The market share of the firms in the coalition was found to be significant only for the buyers of compatible products, i.e., the monopsony power was significant, not the monopoly power. In addition, the technologies whose sponsors weighted market factors more highly than technical factors were more likely to be adopted in the standards decision studied. The proponents of both the adopted and non-adopted technologies were found to have equal belief in the overall technical superiority of their technical alternative, even after the decision. The installed base of a technology and process skills were not found to be significant predictors of the committee outcome.
GENETIC CONTROL OF THE IMMUNE RESPONSE TO FERRITIN IN MICE (1976)

The immune response to the antigen horse spleen ferritin was tested in sixteen inbred strains of mice. Using a fixed antigen percentage bound isotope technique, it was found that the quantity of antibody produced was related to the genetic status of the responding animal. A continuous distribution of responses was obtained, which were found to be linked to H-2 loci and the 2 non-H-2 loci 'Tla' and 'Theta' and these responses are detectable following primary immunization. It is suggested that the continuous distribution of quantitative antibody responses to ferritin, is compatible either with a large number of IR-genes or with a cross tolerance hypothesis requiring no IR-genes at all.
Re: Prostate Cancer Risk Inflation as a Consequence of Image-Targeted Biopsy of the Prostate: A Computer Simulation Study (2013)

No AccessJournal of UrologyAdult Urology1 Aug 2013Re: Prostate Cancer Risk Inflation as a Consequence of Image-Targeted Biopsy of the Prostate: A Computer Simulation Study Samir S. TanejaM.D. Samir S. TanejaSamir S. Taneja More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.04.115AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Prostate Cancer Risk Inflation as a Consequence of Image-Targeted Biopsy of the Prostate: A Computer Simulation Study." The Journal of Urology, 190(2), p. 535 © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 190Issue 2August 2013Page: 535Supplementary Materials Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Samir S. Taneja More articles by this author Expand All Advertisement PDF DownloadLoading ...