gebhart/patrepeval huggingface dataset:
Pilot Trial of Alternating Paclitaxel and Doxorubicin in Advanced Breast Cancer (1997)

Abstract: Studies combining paclitaxel and doxorubicin in the treatment of metastatic breast cancer have shown dose-limiting toxicities and raised questions relating to the risk of cardiac toxicities. This pilot trial evaluates an alternating approach to assess safety and feasibility of paclitaxel alternating with doxorubicin as chemotherapy for recurrent breast cancer. Twelve patients with measurable or evaluable breast cancer who had received no more than one prior chemotherapy (either as adjuvant therapy or therapy for metastatic disease) and no prior anthracycline- or taxane-containing chemotherapy were included. Paclitaxel was administered at 200 mg/2 as a continuous 24-hour intravenous infusion alternating with doxorubicin at 75 mg/m2 intravenously, administered every 21 days for a maximum of 10 cycles of therapy. Objective responses were observed in seven of 12 patients (58%) (three complete responses and four partial responses). Objective responses were seen in lymph node, visceral, soft tissue, and bony sites of metastases. The median duration of response was 9.6 months (range 1.4–20.6). A total number of 102 cycles of therapy were administered with 8 of 12 patients tolerating all 10 cycles (median of 10 cycles per patient, range 2–10). Adverse effects included mild myalgias, arthralgias, and peripheral neuropathies. Cardiac toxicities included asymptomatic sinus tachycardia, sinus bradycardia, and nonspecific T-wave abnormality. One patient experienced left ventricular failure. There were no serious hypersensitivity reactions. Paclitaxel cycles resulted in lower granulocyte nadirs than doxorubicin cycles. There were no significant differences in thrombocytopenia between the two agents. The feasibility of administering paclitaxel and doxorubicin in alternating cycles was demonstrated. This was a well-tolerated regimen with results supportive of safety in administration in an alternating regimen.
Self-Capacitance of High-Voltage Transformers (2007)

The calculation of a transformer's parasitics, such as its self capacitance, is fundamental for predicting the frequency behavior of the device, reducing this capacitance value and moreover for more advanced aims of capacitance integration and cancellation. This paper presents a comprehensive procedure for calculating all contributions to the self-capacitance of high-voltage transformers and provides a detailed analysis of the problem, based on a physical approach. The advantages of the analytical formulation of the problem rather than a finite element method analysis are discussed. The approach and formulas presented in this paper can also be used for other wound components rather than just step-up transformers. Finally, analytical and experimental results are presented for three different high-voltage transformer architectures.
Hydrogel Patterning: (Swelling‐Induced Surface Patterns in Hydrogels with Gradient Crosslinking Density) Adv. Funct. Mater. 19/2009 (2009)

In this paper by M. Guvendiren et al, a simple and robust method is used to generate a range of osmotically-driven surface patterns in hydrogels, including random, lamellar, peanut, and hexagonal structures. The patterns are fabricated by exposing a photocurable formulation to light while open to air and then swelling, using oxygen inhibition of the radical polymerization at the surface to create a gradient of crosslinking with depth.
Distribution capacitor automation provides integrated control of customer voltage levels and distribution reactive power flow (2002)

Southern California Edison Company's (SCE) capacitor automation project reduces overall net energy transfer from the substation to the customer while meeting system VAr requirements. The automated capacitor switching system developed by SCE uses new electronic meters to read real-time customer voltages and energy consumption. Two-way packet radios communicate this customer voltage data and capacitor status information to SCE computers, where a control algorithm determines the optimal capacitor-switching pattern, fine-tuning customer voltages to reduce energy consumption. Substation VAr data is integrated into the control scheme. Testing performed during the period January-December 1993 recorded an average reduction of 4.2 volts in customer voltages when the DCAP algorithm was not controlling switching of capacitors, compared against voltages when the DCAP algorithm was not controlling capacitor switching. SCE has implemented the system on 586 circuit capacitors (including 34 substation capacitors) on 174 circuits served from 20 substations.
The Islamic Ascendancy (2012)

This chapter studies the emergence of Islam, a civilization that found value in previous works and teachings on nature, medicine, and science. It shows that Arab physicians referred to the works of Aristotle and Galen to help improve their science and guide them through medical knowledge and practice. This chapter shows a renewal in anatomical investigation and studies Islamic medicine and science.
Equivalent networks for SAW gratings (1988)

An equivalent-network approach is described for the analysis of surface-acoustic-wave gratings. Circuit parameters can be theoretically determined by applying the finite-element method to an infinite array. In this approach, all of the effects of piezoelectric perturbation, mechanical perturbation, and energy storage are taken into account. To show the validity and usefulness of this approach, examples are computed for groove and metallic gratings. Both short and open circuited metallic gratings are treated. For grooves on isotropic and Y-Z LiNbO(3) substrates, the dependence of reflection characteristics on groove depth is investigated. For aluminum strips on X-112 degrees Y LiTaO(3) 34 degrees Y-X quartz, Y-Z LiNbO(3), and 128 degrees Y -X LiNbO(3) substrates, the dependence on metallization ratio is investigated in detail.
The Interrelationship Between Gastric pH and Therapeutic Response to Esomeprazole in Patients with Uninvestigated Dyspepsia (2008)

Purpose: Management of dyspepsia remains a challenge both in research and clinical practice. Pharmacological therapy, targeting gastric acid suppression results in relief of symptoms in majority of patients complaining of epigastric pain/discomfort related to uninvestigated dyspepsia; however, the relationship between symptom relief and the degree of acid suppression has not been adequately explored. Therefore, the aims of the study were as follows: 1. To evaluate the impact of esomeprazole vs. placebo on gastric acid during 24 h pH monitoring. 2. To asses the relationship between relief of dyspepsia symptoms and changes in gastric pH. Methods: This randomized, double-blind trial was conducted on KUMC patients with uninvestigated dyspepsia, diagnosed acc. to Rome II criteria, with at least moderately severe symptoms of epigastric pain/discomfort. Patients with heartburn or regurgitation as their predominant symptoms, H. pylori (+) or aspirin-like drugs users were excluded. Patients (mean age of 44.2; 62.2% F) were randomized to placebo (N = 35) or esomeprazole (N = 38) 40 mg QD groups. Primary outcome measures were satisfactory relief of pain/discomfort symptoms, a 7-day daily diary preceding each visit, quality of life questionnaire, and global overall symptoms assessment. Gastric pH was monitored for 24 h at baseline and after 4 and 8 weeks of therapy, using dual probe catheter and pH Monitoring System (Sandhill Sci.). Results: Both responders (R) and non-responders (NR) exhibited similar baseline gastric acid secretion at distal (D) and proximal (P) probes: (pH > 4.0 in min) 201 min RD, 177 min NRD, 641 min RP, and 628 min NRP, respectively. Administration of esomeprazole for 4 weeks resulted in profound inhibition of gastric acid secretion reflected by significant (P < 0.01) increase in time pH > 4.0 both among R and NR at D and P pH probe locations. During 2nd therapy interval R exhibited, however, higher degree of gastric acid inhibition, 361% (P < 0.001) increase of time pH >4.0 over baseline value in D probe, whereas NR only 157% (P= 0.12) increase. Higher degree of gastric acid inhibition, 162% (P < 0.001) over baseline value, was also revealed in the P probe in R vs. only 97% increase in NR (P= 0.22). Conclusion: 1. Intragastric pH monitoring before and after therapy may help to address interrelationship between symptomatic relief of dyspepsia symptoms and gastric acid secretion inhibition and could potentially help to tailor individual therapy. 2. Esomeprazole, 40 QD, provides profound inhibition of gastric acid secretion as reflected in time pH > 4.0 in patient with dyspepsia accompanied by significant relief of symptoms.
Techniques of Vacuum Ultraviolet Spectroscopy (1968)

Share Icon Share Twitter Facebook Reddit LinkedIn Reprints and Permissions Cite Icon Cite Search Site Citation James A. R. Samson, Stanley S. Ballard; Techniques of Vacuum Ultraviolet Spectroscopy. Physics Today 1 December 1968; 21 (12): 79–81. https://doi.org/10.1063/1.3034674 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentPhysics Today Search Advanced Search
OC07 CAN WE USE THE NEW INFANT JARVIK 2015 IN PATIENTS LESS THAN 8KG? A SIMULATION STUDY (2018)

Objective: to study test the feasibility of implanting the Infant Jarvik 2015 in patients lower than 8 kg. Methods: The LVAD was tested in a hybrid simulator of the cardiovascular system reproducing specific haemodynamic for different patients weight (2–8 kg). For each weight, we tested the LVAD sensitivity to circulatory parameters (pheripheral resistance, left and right ventricular elastances, heart rate and heart filling) repeating for each experiment a pump ramp (10000–18000 rpm). Results: The increment of the pump speed causes a decrement (increment) of the left (right) atrial pressure, an increment (decrement) of the arterial systemic (pulmonary) pressure, an increment of the right ventricular pressure, a decrement (increment) of the left (right) ventricular volume, a decrement of the left ventricular cardiac output, an increment of the LVAD output and an increment of the right ventricular cardiac output (total cardiac output). Suction was observed for lower weight patients and for higher pump speed in the case of vasodilation, left ventricular recovery, bradycardia, right ventricular failure and left ventricular hypertrophy, while backflow was observed only in the case of left ventricular recovery at lower pump speed. Conclusions: the use of a hybrid circulatory permits to test innovative VAD and the sensitivity of the pump to different circulatory parameters. In this specific application, the Infant Jarvik 2015 was suitable for the implantation in lower weight patients because of the stability respect to the cardiocirculatory changes (low frequency of suction and backflow) and because of the capability of the device in maintaining an adequate patients haemodynamics.
Development of advanced driver assistance systems with vehicle hardware-in-the-loop simulations (2006)

This paper presents a new method for the design and validation of advanced driver assistance systems (ADASs). With vehicle hardware-in-the-loop (VEHIL) simulations, the development process, and more specifically the validation phase, of intelligent vehicles is carried out safer, cheaper, and is more manageable. In the VEHIL laboratory, a full-scale ADAS-equipped vehicle is set up in a hardware-in-the-loop simulation environment, where a chassis dynamometer is used to emulate the road interaction and robot vehicles to represent other traffic. In this controlled environment, the performance and dependability of an ADAS is tested to great accuracy and reliability. The working principle and the added value of VEHIL are demonstrated with test results of an adaptive cruise control and a forward collision warning system. On the basis of the ‘V’ diagram, the position of VEHIL in the development process of ADASs is illustrated.
Silk® Flow Diverter Device for Intracranial Aneurysm Treatment: A Systematic Review and Meta-Analysis (2021)

Flow diverters have become a critical instrument for complex aneurysms treatment. However, limited data are currently available regarding short and long-term outcomes for the Silk flow diverter. The objective of the study is to determine neurological prognosis and mortality rates for the Silk flow diversion device used in intracranial aneurysms. A systematic review with meta-analysis was performed using databases. The following descriptors were used for the search: "SILK", "Flow Diverter", "Mortality", and "Prognosis". The following data were extracted: mortality, good functional outcome, Glasgow outcome scale, complete or near-complete occlusion rates, rate of retreatment, and complications (thromboembolic and hemorrhagic complications). A total of 14 studies were selected. Among the 14 studies, 13 were retrospective observational cohort studies and 1 was a prospective observational cohort study. The mortality rate was 2.84%. The clinical good outcomes rate was 93.3%. The poor outcome rate was 6.6%. The overall thromboembolic complication rate was 6.06% (95% confidence interval [CI] 0.00-6.37, P=0.12, I2=3.13%). The total hemorrhagic complication rate was 1.62% (95% CI 0.00-5.34, P=0.28, I2=1.56%). The complete aneurysm occlusion rate was 80.4% (95% CI 8.65-9.38, P<0.0001, I2=9.09%). The Silk diverter device has a good safety and efficacy profile for treating intracranial aneurysms with high complete occlusion rates.
Lepton flavour universality and lepton flavour conservation tests at CERN (2013)

A precision lepton universality test by measurement of the helicity suppressed ratio of leptonic
decay rates of the charged kaon with 10e5 K+- ->e+- nu decays collected by the NA62 experiment in
2007-08 is presented. The record accuracy of 0.4% constrains the parameter space of new physics
models with extended Higgs sector, a fourth generation of quarks and leptons or sterile neutrinos.
An improved upper limit on the rate of the lepton number violating decay K+- -> mu+- mu+- from
the NA48/2 experiment, which probes the resonant enhancement of the rate in the presence of
heavy Majorana neutrinos in the 100 MeV range, is also presented.
Simultaneous Inhibition of Insulin and Somatomedin-C Binding to Cultured IM-9 Lymphocytes by Naturally Occurring Antireceptor Antibodies (1981)

A 53-y4-old male patient with insulin-resistant diabetes was found to have circulating inhibitors of both insulin and somatomedin-C binding. Serum obtained from the patient at the time of initial presentation inhibited 50% of both 125I-insulin and 125I-SM-C binding to IM-9 lymphocytes at dilutions of 1:150. Spontaneous improvement in the patient's diabetic state was associated with a simultaneous and equal decrease in the serum inhibitory titers for both radioligands. Scatchard analysis indicated that the observed serum-induced decrease in both insulin and SM-C binding was due to decreased receptor affinity, with no alteration in receptor number. The serum inhibitors of both insulin and SM-C binding were precipitated equally by Staph-A and also by 40% ammonium sulfate, suggesting they were immunoglobulins. The observation of naturally occurring autoantibodies against both the insulin and SM-C receptors suggests a structural homology between the two receptors.
Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease (2014)

We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC family amplifications and P53 pathway defects commonly emerged at relapse, and all patients in this group died of rapidly progressive disease postrelapse. To study this interaction, we investigated a transgenic model of MYCN-driven medulloblastoma and found spontaneous development of Trp53 inactivating mutations. Abrogation of p53 function in this model produced aggressive tumors that mimicked characteristics of relapsed human tumors with combined P53-MYC dysfunction. Restoration of p53 activity and genetic and therapeutic suppression of MYCN all reduced tumor growth and prolonged survival. Our findings identify P53-MYC interactions at medulloblastoma relapse as biomarkers of clinically aggressive disease that may be targeted therapeutically.
Task-Aware Novelty Detection for Visual-based Deep Learning in Autonomous Systems (2020)

Deep-learning driven safety-critical autonomous systems, such as self-driving cars, must be able to detect situations where its trained model is not able to make a trustworthy prediction. This ability to determine the novelty of a new input with respect to a trained model is critical for such systems because novel inputs due to changes in the environment, adversarial attacks, or even unintentional noise can potentially lead to erroneous, perhaps life-threatening decisions. This paper proposes a learning framework that leverages information learned by the prediction model in a task-aware manner to detect novel scenarios. We use network saliency to provide the learning architecture with knowledge of the input areas that are most relevant to the decision-making and learn an association between the saliency map and the predicted output to determine the novelty of the input. We demonstrate the efficacy of this method through experiments on real-world driving datasets as well as through driving scenarios in our in-house indoor driving environment where the novel image can be sampled from another similar driving dataset with similar features or from adversarial attacked images from the training dataset. We find that our method is able to systematically detect novel inputs and quantify the deviation from the target prediction through this task-aware approach.
Advancements on near-zero power mems sensors (2022)

Due to the fast development of the internet of things, the number of connected devices worldwide is expected to increase exponentially. Currently no existing technology could enable the implementation of large-scale wireless sensor networks in remote locations due to the prohibitive cost associated with installation and maintenance. Commercially available sensors are not "smart" enough to identify targets of interest without consuming any power or detect and discriminate signal of interest. Therefore, they consume power continuously to monitor the environment even when there is no relevant data to be detected, which results in a short battery lifetime limited to very few months. This dissertation presents improvements on a new class of near zero-power microsystems that fundamentally break the paradigm, with zero-power consumption, until awakened by a specific physical signature. Field-of-view characterization, ambient temperature response, dynamic biasing, self-checking functionalities, vacuum packaging, endurance tests, false stimuli rejection and in-field power requirements are investigated. In particular, I have experimentally demonstrated zero-power wireless sensors triggered by different physical and chemical quantities such as: infrared radiation for flame detection and volatile organic chemicals for plant health monitoring. The capabilities of the zero-power sensors result in a nearly unlimited duration of operation, with a groundbreaking impact on the proliferation of the internet of things.--Author's abstract
Extracellular microbial proteases with specificity for plant proteins in food fermentation (2022)

Plant-based food products are generating a growing interest as part of the ongoing transition to a primarily plant-based diet, which makes demands to the quality, functionality, and health properties of plant proteins. Microbes used for traditional food fermentations such as lactic acid bacteria (LAB) and fungi (yeasts and molds) carry out enzymatic changes on their protein substrates by which technological and sensorial characteristics can be improved. The literature on extracellular proteases targeting plant proteins, on the other hand, is scattered with only a narrow representation of plants even for traditionally plant-based products. Therefore, this review aims to explore the current state of knowledge regarding the application potential of microbial extracellular proteases targeting plant proteins, with a focus on traditional applied food microbes. Plant proteins are targeted by proteolytic microbes of both animal and plant origins, and their proteases show a wide range of activities. Extracellular microbial proteases can hydrolyze specific protein-based allergens and even reduce the toxicity of plant proteins. Additionally, microbial assisted proteolysis can improve plant protein digestibility by increasing availability of peptides and amino acids. This catabolic process will change the organoleptic characteristics of fermented plant proteins, and the release of bioactive peptides can provide additional functionalities to the plant matrix. The proteolytic activity is determined by the microbial strain, and it can be quite substrate selective, which is why proteases may be overlooked by the prevalent use of casein as substrate in proteolytic screenings. The synergetic effects of LAB and fungal species consortia can facilitate and steer plant protein hydrolysis by which co-fermentation may increase or change the properties of plant protein hydrolysates. Microbes do not necessarily require extracellular proteases because endogenous proteases in a plant-matrix may meet the microbial amino acid requirements. However, extracellular proteases have the potential to provide central properties to diverse food-matrixes by which the full proteolytic potential of food microbes needs to be explored in order to facilitate the development of high-quality plant-based food products.
The effects of alpha‐helix on the stability of Asn residues: Deamidation rates in peptides of varying helicity (1999)

Asn deamidation was monitored in Ala-based octadecapeptides of varying alpha-helicity. Gly was substituted for Ala residues at positions 6 and 16 to create a peptide with less helicity. Ala --> Gly substitutions were made at three or more residues from the Asn to negate known primary sequence effects on deamidation rates. The extent of helicity and rate of Asn deamidation for alkaline aqueous solutions of each peptide was measured as a function of temperature by circular dichroism and reversed-phase high-performance liquid chromatography, respectively. The rate of deamidation in the peptides was inversely proportional to the extent of alpha-helicity. The results support the conclusion that Asn deamidation only occurs in the nonhelical population of conformers.
Synthetic Quartz with High Ultraviolet Transmission (1968)

Quartz has been synthesized under hydrothermal conditions at rates of 1.78 mm/day in the presence of LiNO(2) in Ag lined and Ag plated systems, and it is shown that such quartz has optical transmission between 1500 A and 3 micro equal, and in some cases superior to, natural quartz. The uv cutoff at about 1500 A has been shown to be associated with Fe whose concentration may be reduced by procedures that reduce the concentration of charge compensating H+ in the lattice (growth in LiNO(2)) and by procedures which reduce the concentration of Fe in solutions (inert conditions). Transmission near 3 micro is affected by OH which can be reduced by LiNO(2).