gebhart/patrepeval huggingface dataset:
Immunogenicity and Reactogenicity of Four Doses of Diphtheria-Tetanus-Three-Component Acellular Pertussis-Hepatitis B-Inactivated Polio Virus-Haemophilus influenzae Type b Vaccine Coadministered with 7-Valent Pneumococcal Conjugate Vaccine (2005)

Coadministration of the DTPa-HBV-IPV/Hib and 7vPn vaccines at separate injection sites during the same vaccination visit was effective and safe.
Multisensor tracking and fusion for maritime surveillance (2007)

Over the past several years, the NATO Undersea Research Centre has conducted extensive research in multisensor networks for undersea surveillance, culminating in the development of the DMHT tracker. In this paper, we discuss upgrades to this technology and its application to maritime surveillance.
Electrophotography (1977)

Abstract Electrophotographic images are formed by the displacement of matter in electric fields: the deposition of charged particles or the deformation of a plastic surface is controlled by a geometric field pattern, configured by the photo‐response of a photoconductive insulating material. Image amplification up to 10 5 may be achieved by the application of external potentials and the judicious selection of imaging particles having a high ratio of absorbance per unit charge. These particles may be ions, colloids, photoresponsive pigments, or (most commonly) colored plastic “toner” composites. Of the many processes which have been invented to date, transfer xerography remains the most useful. This paper presents a concise review of electrophotographic imaging processes and materials, as well as of some of their applications.
Ligands bifonctionnels : des modes de coordination inusuels, vers de nouvelles approches en catalyse ? (2006)

International audience
Genome Scan for Blood Pressure in Dutch Dyslipidemic Families Reveals Linkage to a Locus on Chromosome 4p (2001)

Genes contributing to common forms of hypertension are largely unknown. A number of studies in humans and in animal models have revealed associations between insulin resistance, dyslipidemia, and elevated hypertension. To identify genes contributing to blood pressure (BP) variation associated with insulin-resistant dyslipidemia, we conducted a genome-wide scan for BP in a set of 18 Dutch families exhibiting the common lipid disorder familial combined hyperlipidemia. Our results reveal a locus on chromosome 4 that exhibits a significant lod score of 3.9 with systolic BP. In addition, this locus also appears to influence plasma free fatty acid levels (lod=2.4). After adjustment for age and gender, the lod score for systolic BP increased to 4.6, whereas the lod score for free fatty acid levels did not change. The chromosome 4 locus contains an attractive candidate gene, alpha-adducin, which has been associated with altered BP in animal studies and in some human populations. However, we found no evidence for an association between 2 intragenic alpha-adducin polymorphisms and systolic BP in this sample. We also observed suggestive evidence for linkage (lod=1.8) of diastolic BP to the lipoprotein lipase gene locus on chromosome 8p, supporting a finding previously observed in a separate insulin-resistant population. In addition, we also obtained suggestive evidence for linkage of systolic BP (lod=2.4) and plasma apolipoprotein B levels (lod=2.0) to a locus on proximal chromosome 19p. In conclusion, our genome scan results support the existence of multiple genetic factors that can influence both BP and plasma lipid parameters.
“Calling Bullshit” (2021)

This chapter reports an original experimental study that explores the idea that “calling bullshit” may shed light on how we reach a conclusion quickly, following Mercier and Sperber's social intuitionist theory of how we reason. According to the social intuitionist model, instead of going from deliberating and finding reasons prior to arriving at conclusions, as in the rationalist model, we typically go from conclusions backwards to reasons. Little if any empirical research has studied how we come to the determination “that's bullshit,” especially our ability to decide that something is bullshit so quickly. This study explores the relationship between the strength of belief in four ideologies and the speed of “calling bullshit.” The experiment tests the effect of strength of belief in the worldviews of Individualism, Communitarianism, Hierarchicalism, and Egalitarianism. It also examines reaction time for instances of confirming versus disconfirming the subject's worldview as well as age of the subject.
A Curvature-Based Descriptor for Point Cloud Alignment Using Conformal Geometric Algebra (2018)

This paper presents a descriptor for course alignment of point clouds using conformal geometric algebra. The method is based on selecting keypoints depending on shape factors to identify distinct features of the object represented by the point cloud, and a descriptor is then calculated for each keypoint by fitting two spheres that describe the local curvature. The method for estimating the point correspondences is to a larger extent based on geometric arguments than the method of Kleppe et al. (IEEE Trans Autom Sci Eng, 2017), which results in improved performance. The accuracy of the curvature-based descriptor is validated in experiments, and is shown to compare favorably to state-of-the-art methods in an experiment on course alignment of industrial parts to be assembled with robots.
Comprehensive description of the electro-optic effects in strained silicon waveguides (2017)

We present a novel and comprehensive analysis method that considers both the plasma-dispersion effect and the strain-induced Pockels effect to faithfully describe the electro-optic effects taking place in a strained silicon waveguide under an applied voltage. The change in carrier distribution arising from the application of a voltage leads to a redistribution of the electrostatic field which deeply affects the strain-induced Pockels effect. By simulating the strain gradient distribution inside the waveguide together with the free carrier concentration in silicon, we were able to describe that the effective index change due to the Pockels effect in strained silicon waveguides and the applied voltage have a nonlinear relationship.
Performance of InP/InGaAs Heterojunction Bipolar Transistors For 40Gb/s OEIC Applications (2002)

A high performance InP/InGaAs SHBT technology will be presented. InP SHBT is advantageous in terms of low-cost monolithic integration with photodiodes for high-speed optical receiver frontend applications. We will demonstrate that, through optimized CAD geometries, the fabricated HBTs showed uniform and improved device performance. Our best results show that an fT of over 160 GHz and fmax of greater than 250 GHz are achieved on InP/InGaAs SHBTs with a collector thickness of 3000A.
Influence of Initial Surface Roughness on LIPSS Formation and Its Consecutive Impact on Cell/Bacteria Attachment for TiAl6V4 Surfaces (2023)

Abstract The influence of the initial surface roughness of TiAl6V4 samples on the orientation and periodicity of the resulting laser‐induced periodic surface structures (LIPSS), as well as the surface wettability and chemistry is reported here. Before LIPSS fabrication, initial sample surface roughness is adjusted by variations of finial polishing steps with polishing grain sizes of 18.3, 8.4, 5, and 0.5 µm. A 3 × 3 irradiation matrix was defined and lasered on all samples by changing the laser power and distance between consecutive laser scans. The resulting structures were characterized by scanning electron microscopy (SEM), atomic force microscopy, Raman spectroscopy, and contact angle measurements. As a further step, three representative generated structures were chosen to explore their bone implant viability by resazurin assays, alkaline phosphatase activity, and direct SEM imaging of the induced cells (MG63) and bacteria ( Escherichia coli and Staphylococcus aureus ). Results show that initial surface roughness has big influence on the wettability of the resulting surface, as well as inducing small variations on the orientation of the generated LIPSS. Structures generated with a higher integrated fluence have also shown to enhance cell differentiation while reducing bacterial activity, making them a great candidate for improved bone implant compatibility and durability.
Aromatase inhibition in ovarian cancer: repeated signals of efficacy but tools for patient selection remain elusive (2019)

the "PARAGON (ANZGOG-0903): a phase 2 study of anastrozole in asymptomatic patients with estrogen and progesterone receptor-positive recurrent ovarian cancer and CA125 progression" in volume 30, e86.
Ultrastructural localization of nonspecific esterase activity in guinea pig and human monocytes, macrophages, and lymphocytes (1981)

Using either hexazotized pararosaniline or new fuchsin as coupling agents, we investigated the ultrastructural localization of alpha- naphthyl acetate esterase (ANAE) activity in guinea pig bone marrow and peritoneal exudates, and in human peripheral blood cells. DFP- inhibitable ANAE activity was present on the cell surface of lymphocytes, monocytes, macrophages, neutrophils, eosinophils, basophils, megakaryocytes, platelets, and blasts. Demarcation lines in megakaryocytes and the perinuclear cisternae in normoblasts were also positive. In addition, lymphocytes, monocytes, and macrophages displayed ANAE activity associated with cytoplasmic-vesicle clusters (CVC). Reaction product was always present on the cytoplasmic surfaces of these vesicles and in the adjacent cytoplasm; vesicle interiors were invariably ANAE-negative. Small lymphocytes generally had a single large paranuclear ANAE-positive CVC, whereas mononuclear phagocytes had multiple discrete foci of similar appearing ANAE-positive CVC that sometime became confluent. ANAE activity was also found in the Gall bodies of human lymphocytes and in coated vesicles of macrophages. Cytoplasmic ANAE activity was increased in oil-induced guinea pig peritoneal macrophages. Both surface and cytoplasmic esterase activities had a neutral pH optimum. An identical distribution of reaction product was observed when alpha-naphthyl butyrate was employed as substrate. The function of these esterases, and their relation to known surface and cytoplasmic neutral proteases, awaits further investigation.
Endometrium in in-vitro fertilization cycles: morphological and functional differentiation in the implantation phase (1992)

Secretory differentiation of endometrium after multiple follicular stimulation using gonadotrophin releasing hormone and human menopausal gonadotrophin has been studied both histologically and immunohistochemically in 30 women undergoing in-vitro fertilization treatment. None had embryo transfer. Patients were randomly allocated to receive luteal phase support with a single dose of human chorionic gonadotrophin. The latter failed to produce any significant enhancement of endometrial structure or secretions. Appropriate glandular morphology was present in a greater proportion of those who were successfully stimulated than those who responded poorly. However, defective secretion of the cycle-dependent component studied, using monoclonal antibody D9B1, was demonstrated in two-thirds of cases regardless of the ovarian response. Early vascular maturation in the stroma was a common finding, and was thus considered as a feature of structural modulation of these endometria.
Loss of virulence inLeishmania donovanideficient in an amastigote-specific protein, A2 (1997)

Leishmania donovani is the etiologic agent of fatal visceral leishmaniasis in man. During their life cycle, Leishmania exist as flagellated promastigotes within the sandfly vector and as nonflagellated amastigotes in the macrophage phagolysosomal compartment of the mammalian host. The transformation from promastigotes to amastigotes is a critical step for the establishment of infection, and the molecular basis for this transformation is poorly understood. To define the molecular basis for amastigote survival in the mammalian host, we previously identified an amastigote stage-specific gene family termed "A2." In the present study, we have inhibited the expression of A2 mRNA and A2 protein in amastigotes using antisense RNA and show that the resulting A2-deficient amastigotes are severely compromised with respect to virulence in mice. Amastigotes that did survive in the mice had restored A2 protein expression. These data demonstrate that A2 protein is required for L. donovani survival in a mammalian host, and this represents the first identified amastigote-specific virulence factor identified in Leishmania. This study also reveals that it is possible to study gene function in Leishmania through the expression of antisense RNA.
A trace-based simulation of pointer swizzling techniques (2002)

Persistent object-oriented applications that traverse large object graphs can improve their performance by caching objects in main memory while they are being used. While caching offers large performance benefits, the techniques used to locate these cached objects in memory can still impede the application's performance. We present the results of a trace-based simulation study of pointer swizzling techniques (techniques for reducing the cost of access to cached objects). We used traces derived from actual persistent programs to find a class of swizzling techniques that performs well, yet permits changes to the contents of in-memory object caches over the lifetime of an application. Our study demonstrates the superiority of a class of techniques known as "indirect swizzling" for a variety of workloads and system configurations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Chiral SC Liquid Crystal Obtained by mixtures and study of the smectic mixtures using the Scheffé algorithm (1983)

Abstract Binary, ternary and quaternary mixtures of four smectogenic compounds: 4,4′‐didecyloxy‐2,2′‐dihydroxybenzalazine, S‐4′‐decyloxy‐2‐hydroxy‐4‐(2‐methylbutoxy)‐α,α′‐dimethylbenzalazine, 4,4′‐didodecyloxy‐2,2′‐dihydroxy‐α,α′‐dimethylbenzalazine and 2‐hydroxy‐4,4′‐dinonyloxy‐α,α'‐dimethylbenzalazine were studied. These systems of mixture were studied using the Scheffé algorithm which had proved to be particularly useful in the study of these types of mixture. Induction of chirality in a S C phase by mixture with compounds optically active was studied. Numerous transition solid‐solid in mixtures during the melting were obtained and their repetition was verified.
Structure of Two in Tandem Human 17β-Hydroxysteroid Dehydrogenase Genes (1990)

Two human 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) genes (h17 beta-HSDI and h17 beta-HSDII) included in tandem within an approximately 13 kilobase pair fragment were isolated from a genomic lambda EMBL3 DNA library using cDNA encoding human 17 beta-HSD (hpE2DH216) as probe. We have determined the complete exon and intron sequences of the two genes as well as their 5' and 3'-flanking regions. Human 17 beta-HSDII contains six exons and five short introns for a total length of 3250 base pairs. The exon sequence of h17 beta-HSDII is identical to the previously reported hpE2DH216 cDNA while the overlapping nucleotide sequences of the corresponding exons and introns of h17 beta-HSDI and h17 beta-HSDII show 89% homology. In addition, we have used the hpE2DH216 cDNA to demonstrate the widespread expression of 17 beta-HSD mRNAs in steroidogenic and peripheral target tissues. These new findings provide the basis for a better understanding of the molecular mechanisms involved in 17 beta-HSD deficiency and peripheral sex steroid metabolism.
Thoracolumbar spinal deformity: Part I. A historical passage to 1990 (2009)

Seven millennia of anthropological artifacts and historical tales reference human spinal deformity, its diagnosis, and treatment-many of the latter of which turned out to be worse than the deformity itself. From Hippocrates to Harrington to the 21st century, the literature base has expanded in exponential fashion to yield an imperfect but constantly improving body of evidence, experience, and understanding of this challenging disease phenomenon. This review details the pre-1990 innovations, whose failures and successes have equally contributed to the advancement and dissemination of the increasingly evidence-based field of spinal deformity.
Human Cytomegalovirus Persists in Its Host and Attacks and Avoids Elimination by the Immune System (2006)

Human cytomegalovirus (HCMV) is a herpesvirus that infects, and is carried by, 70%-100% of the world's population. During its evolution, the virus has adapted to survive in an immunocompetent host. For many years, HCMV was not considered to be a major human pathogen because it only caused rare cases of HCMV inclusion disease in neonates. However, HCMV is poorly adapted to survive in the immunosuppressed host and has emerged as an important human pathogen in AIDS patients, and in patients undergoing immunosuppressive therapy after organ or bone marrow transplantation. The virus is also the major infectious cause of birth defects. To coexist with its host, HCMV must avoid elimination by the immune system. Research over the past decade has revealed sophisticated mechanisms that enable the virus to remain invisible to cells of the immune system.
Synthesis of Novel Halopyridinylboronic Acids and Esters. Part 3. 2, or 3‐Halopyridin‐4‐yl‐boronic Acids and Esters. (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
MR-based attenuation correction for PET/MRI neurological studies with continuous-valued attenuation coefficients for bone through a conversion from R2* to CT-Hounsfield units (2020)

AIM: MR-based correction for photon attenuation in PET/MRI remains challenging, particularly for neurological applications requiring quantitation of data. Existing methods are either not sufficiently accurate or are limited by the computation time required. The goal of this study was to develop an MR-based attenuation correction method that accurately separates bone tissue from air and provides continuous-valued attenuation coefficients for bone. MATERIALS AND METHODS: PET/MRI and CT datasets were obtained from 98 subjects (mean age [±SD]: 66yrs [±9.8], 57 females) using an IRB-approved protocol and with informed consent. Subjects were injected with 352±29MBq of (18)F-Florbetapir tracer, and PET acquisitions were begun either immediately or 50min after injection. CT images of the head were acquired separately using a PET/CT system. Dual echo ultrashort echo-time (UTE) images and two-point Dixon images were acquired. Regions of air were segmented via a threshold of the voxel-wise multiplicative inverse of the UTE echo 1 image. Regions of bone were segmented via a threshold of the R2* image computed from the UTE echo 1 and UTE echo 2 images. Regions of fat and soft tissue were segmented using fat and water images decomposed from the Dixon images. Air, fat, and soft tissue were assigned linear attenuation coefficients (LACs) of 0, 0.092, and 0.1cm(-1), respectively. LACs for bone were derived from a regression analysis between corresponding R2* and CT values. PET images were reconstructed using the gold standard CT method and the proposed CAR-RiDR method. RESULTS: The RiDR segmentation method produces mean Dice coefficient±SD across subjects of 0.75±0.05 for bone and 0.60±0.08 for air. The CAR model for bone LACs greatly improves accuracy in estimating CT values (28.2%±3.0 mean error) compared to the use of a constant CT value (46.9%±5.8, p<10(-6)). Finally, the CAR-RiDR method provides a low whole-brain mean absolute percent-error (MAPE±SD) in PET reconstructions across subjects of 2.55%±0.86. Regional PET errors were also low and ranged from 0.88% to 3.79% in 24 brain ROIs. CONCLUSION: We propose an MR-based attenuation correction method (CAR-RiDR) for quantitative PET neurological imaging. The proposed method employs UTE and Dixon images and consists of two novel components: 1) accurate segmentation of air and bone using the inverse of the UTE1 image and the R2* image, respectively and 2) estimation of continuous LAC values for bone using a regression between R2* and CT-Hounsfield units. From our analysis, we conclude that the proposed method closely approaches (<3% error) the gold standard CT-scaled method in PET reconstruction accuracy.
Correction: Dynamic Changes to the Skeletal Muscle Proteome and Ubiquitinome Induced by the E3 Ligase, ASB2β (2022)

The original version of Fig. 2B contained elements from Fig. 1 of Udeshi, N.D., Mertins, P., Svinkina, T., and Carr, S.A. (2013) Large-scale identification of ubiquitination sites by mass spectrometry. Nat. Protoc. 8, 1950-60. An updated schematic for Fig. 2B (created using Bio- Render.com) is provided below. (Figure Presented).
Turn-on type sensing of methanol vapor by a luminescent platinum(ii) dichloride complex with 21-dibenzoarsacrown-7 (2021)

The development of turn-on detection sensors for methanol vapor remains challenging in materials science. Methanol sensing materials are generally based on vapor-triggered color changes or are turn-off types. Additionally, in general, the selectivity for methanol is limited, and the recyclability is low. Turn-on type sensing, high selectivity, rapid response time, and recyclability are favorable for achieving real-time detection systems. Herein, platinum(ii) dihalide (PtX2, X = Cl, Br, and I) complexes with 21-dibenzoarsacrown-7 were synthesized and their structures were characterized by single-crystal diffraction analysis. The PtCl2 complex showed intense emission when capturing methanol molecules in the crystalline matrix. In addition, this sensing system possessed high selectivity for methanol vapor and required facile recycling procedures.
Pumps And Pipes (2011)

Introduction“The solution to our problems most likely lie in someone else’s toolbox.The challenge is in finding it.”A significant problem in medical technology development, and perhaps the energy business, is that developers are very in-bred — often exposed only to like-minded individuals, which in turn can prevent innovation and maturation of “out-of-the-box” ideas. We believe that great benefit may be gained by exposing cardiovascular and imaging researchers to technology currently available in the oil and gas world. Thus was created the “Pumps and Pipes” symposium, a collaboration between Houston’s two most prominent industries. Pumps and Pipes is a problem-focused forum analyzing issues relevant to both the energy and medical worlds. The goal is to stimulate discussion, spark ideas and brainstorm with industry counterparts to explore complementary technologies using common language and terminology, with such themes as “Docs and Rocks,” “The Other Guy’s Toolkit,” and “Better Together, and “No Boundaries.”