gebhart/patrepeval huggingface dataset:
Improved Creep Resistance of Ti‐6Al–4V Alloy by Electron Beam Welding Process Plus Annealing Treatment and its Microstructure Analysis (2016)

In this study, we investigated the effect of annealing treatments on the creep resistance of Ti-6A1-4V alloy following electron beam welding (EBW) process under the applied stresses of 350, 400, 450, and 500 MPa at 500°C. It appears that when the applied stress is less than 500 MPa, the newly formed α2-Ti3Al and γ-TiAl phases present in the fusion zone may provide stronger resistance to dislocation climbing and gliding during creep, leading to enhanced weld properties. It may explain the superior creep resistance of present Ti-6A1-4V EBW weldments than the unwelded Ti-6A1-4V alloy reported in the literature. Moreover, we report for the first time that α2-Ti3Al formed in the base metal of the annealed Ti-6AWV EBW weldment. The correlation between microstructural evolution and creep properties are analyzed and discussed.
An adaptive subspace approach for speech enhancement (2002)

A new algorithm is proposed for enhancement of speech degraded by colored additive interference. It is observed that the noise energy is disparately distributed along each eigenvector. These energies are obtained from noise samples gathered from silence intervals between speech samples. To obtain these silence intervals, we proposed an efficient voice activity detector based on outputs of principle component eigenfilter. Enhancement is performed by modifying each component due to its noise and clean speech energies. Tests indicated that 71% of our listeners preferred the enhanced speech by the above method over former methods for white Gaussian noise, while 80% of them preferred our method when we processed real noisy speech gathered from various environments.
Issues on deterministic transformation of logic-based program specification (2002)

Issues of logic-based program transformation are discussed, and a method for transforming a source program expressed as a set of extended Horn clauses into a target program in an Algol-like procedural language is presented. The potential applications of this transformation method include (1) automatic synthesis of programs from design specifications which are either written in or translatable into extended Horn logic clauses, (2) adaptation of existing logic programs to a procedural execution environment in order to improve execution efficiency or facilitate reusability of the software, and (3) support of a hybrid-programming environment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
NUMERICAL ANALYSIS OF VALVE STRUCTURE OF HIGH POWER MARINE ENGINE (2021)

Valve as an important part of the gas distribution mechanism, is an crucial part of the engine. When the engine works, the valve is subjected to high temperature, high impact, frictional wear and corrosion and other harsh working conditions, and the reliable and durable valve has an important impact on the safety and reliability of the engine. In this paper, a model of four-stroke marine diesel engine valve is used as the research object, and the intake valve set and exhaust valve set models are established respectively. Heat transfer simulation and failure analysis of inlet and exhaust valves of different structures and materials under different operating conditions were carried out using finite element analysis. The results show that the different valve structures and manufacturing materials have different effects on the reliability of the valves; Changing the valve structures and choosing different valve manufacturing materials have a greater impact on the heat transfer and deformation, thus affecting the overall reliability of the valves.
Outside the Box- HVAC Management Techniques That Consider the World Around Them (2007)

SUMMARY This paper summarises CSIRO’s work on intelligent HVAC management techniques, with a particular focus on techniques designed to participate in demand management programmes. Such programmes are of significant interest, seen as a way of reducing expenditure and minimizing energy consumption in electricity systems around the world. CSIRO’s aim is to design intelligent HVAC controllers that can enable automated participation in energy demand management programmes, benefiting both the local system owner as well as the electricity business, whilst still considering factors such as occupant comfort. This paper describes our investigations into the application of machine learning techniques towards such a controller. It also summarises our recent experiments trialling demand management techniques (through setpoint variation) in a multi-story building HVAC deployment.
Region specific knock-out reveals distinct roles of chromatin modifiers in adult neurogenic niches (2018)

Histone methyltransferases (HMTs) are present in heterogeneous cell populations within the adult brain including neurogenic niches. Yet the question remains whether loss of HMTs and the resulting changes in histone methylation alter cell fate in a region-specific manner. We utilized stereotaxic injection of Cre recombinant protein into the adult neurogenic niches, the subventricular zone (SVZ) adjacent to the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus. We confirmed that Cre protein was enzymatically active in vivo and recombination events were restricted to the vicinity of injection areas. In this study, we focus on using Cre mediated recombination in mice harboring floxed HMT: enhancer of zeste homolog 2 (EZH2) or suppressor of variegation homolog (Suv4-20h). Injectable Cre protein successfully knocked out either EZH2 or Suv4-20h, allowing assessment of long-term effects in a region-specific fashion. We performed meso-scale imaging and flow cytometry for phenotype analysis and unbiased quantification. We demonstrated that regional loss of EZH2 affects the differentiation paradigm of neural stem progenitor cells as well as the maintenance of stem cell population. We further demonstrated that regional loss of Suv4-20h influences the cell cycle but does not affect stem cell differentiation patterns. Therefore, Cre protein mediated knock-out a given HMT unravel their distinguishable and important roles in adult neurogenic niches. This Cre protein-based approach offers tightly-controlled knockouts in multiple cell types simultaneously for studying diverse regulatory mechanisms and is optimal for region-specific manipulation within complex, heterogeneous brain architectures.
Combination therapy with lamivudine and famciclovir for chronic hepatitis B-infected Chinese patients: A viral dynamics study (2000)

In vitro studies have shown that lamivudine and penciclovir (the active metabolite of famciclovir) act synergistically to inhibit hepatitis B virus (HBV) replication. We compared the effectiveness of HBV viral suppression by lamivudine monotherapy versus lamivudine plus famciclovir combination therapy in Chinese patients with chronic HBV infection. Twenty-one Chinese hepatitis B e antigen (HBeAg)-positive patients, with detectable HBV DNA (Digene Hybrid Capture II), were randomized to receive either lamivudine 150 mg/d orally (group 1, 9 patients) or lamivudine 150 mg/d plus famciclovir 500 mg 3 times a day orally (group 2, 12 patients) for 12 weeks, with a follow-up period of at least 16 weeks. Serial serum HBV-DNA levels were determined and a mathematical model with provision for incomplete inhibition of virus production during therapy was applied to analyze the dynamics of viral clearance. The mean antiviral efficacy was significantly greater in group 2 than in group 1 (0.988 +/- 0.012 vs. 0.94 +/- 0.03, P =.0012). HBV DNA returned to pretreatment level within 16 weeks after the end of initial treatment in 4 patients (66.7%) in group 1 and none in group 2 (P =.08), who remained HBeAg positive and received no further treatment after week 12. Hence, in Chinese chronic HBeAg-positive patients, combination therapy using lamivudine and famciclovir was superior to lamivudine monotherapy in inhibiting HBV replication. Further studies of longer duration are needed to define whether combination therapy will increase the HBeAg seroconversion rate and decrease the rate of emergence of lamivudine-resistant variants.
A Finite Element Model of a Rotating Platform Total Knee Employing a Nonlinear, Dual-Surface-Contact Formulation (2000)

Abstract Mobile bearing total knees avoid the conformity/constraint tradeoff of fixed bearing total knees. However, a recent in vivo fluoroscopic study of the most popular mobile bearing total knee in the U.S. showed that bearing motion failed to occur in half of the patients observed. A nonlinear, multiple-surface contact finite element model of a rotating platform total knee was therefore developed to investigate the interaction at the “mobile” interface (contact between the tibial tray and the polyethylene insert) under physiologically relevant loads (1–4 BW) and rotations (10° endorotation). The data showed that there was a linear relationship between axial load and the torque resisting endorotation. Peak contact stresses were located on the medial and lateral peripheral edges of the polyethylene insert. All relative rotation occurred at the “mobile” interface. The same trends were seen in a complementary experimental study of the same components, suggesting that the finite element model is valid under these loading conditions.
The Liquid State: Applications of Molecular Simulations (1998)

Statistical Mechanics of Liquids. Monte Carlo Simulation. Molecular Dynamics Simulation. Liquids in Motion. Liquids Far From Equilibrium. Liquids in the Bulk. Liquids at Surfaces. Equations of State and Phase Boundaries. References. Index.
Strain-induced control of magnetocrystalline anisotropy energy in FeCo thin films (2020)

We use density functional theory calculations to compute the lateral strain dependence of the magnetocrystalline anisotropy (MCA) energy of thin FeCo films. We investigate the effect of lateral strain on the MCA energy especially in the context of magnetostriction, which needs to be minimized for some applications like GMR sensors. The magneto-elastic coupling responsible for magnetostriction is a strain-derivative of the MCA energy, thus we concentrate to find extrema in the MCA energy vs. strain curves, which we find for both ordered Fe50Co50 films, as well as for disordered Fe10Co90 films modeled by special quasirandom structures. We show that using lateral strain we can switch the easy axis of magnetization from out-of-plane to in-plane in many cases. We can furthermore use lateral strain in combination with the film-thickness to minimize magnetostriction and change the MCA energy at the same time.
Refill Friction Stir Spot Joining Rivet Replacement Technology (2016)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The Refill Friction Spot Joining (RFSJ) is an emerging solid-state spot welding technology that thermo-mechanically creates a molecular-level bond between the work-pieces. RFSJ does not consume any filler or foreign materials so that no additional weight is introduced to the assembly. As the solid-to-liquid phase transition is not involved in RFSJ in general, there is no lack of fusion or material deterioration caused by liquefaction and solidification. Unlike the conventional friction stir spot welding, RFSJ produces a spot joint with a perfectly flush surface finish without a key or exit hole. Currently, the aerospace industry employs solid rivets for fastening the primary structures as they meet the baseline requirements and have well-established standards and specifications. However, the riveting process consists of tedious resource-intensive steps, such as hole-drilling, deburring, fastener insertion, and fastener clinching, which reduce the cost efficiency of the entire assembly process. Furthermore, some rivets produce uneven joint surfaces due to their protruding ends that cause not only air turbulence issues but also surface appearance issues in the aircraft structures. Kawasaki Heavy Industries has advanced the basic friction stir spot welding concept and developed a robotic system that is capable of producing refill friction-stir-spot joints in aluminum structures. The ultimate goal of this study is to investigate whether RFSJ is capable of replacing solid rivets in joining the primary aluminum structures of aircraft. The presented results demonstrate a process development methodology as well as mechanical and metallurgical properties of the joint produced by an optimized RFSJ process.&lt;/div&gt;&lt;/div&gt;
Cracking of Stressed Polyethylene (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCracking of Stressed PolyethyleneJ. B. DeCoste, F. S. Malm, and V. T. WallderCite this: Ind. Eng. Chem. 1951, 43, 1, 117–121Publication Date (Print):January 1, 1951Publication History Published online1 May 2002Published inissue 1 January 1951https://pubs.acs.org/doi/10.1021/ie50493a035https://doi.org/10.1021/ie50493a035research-articleACS PublicationsRequest reuse permissionsArticle Views221Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Optimal Laser Power to Rupture Bruch's Membrane and the Retinal Vein in the Pig (2003)

Argon green laser powers of at least 2.5 and 3.0 W were necessary to rupture Bruch's membrane and the retinal vein, respectively, with a 100% success rate in the porcine eye. Because patients with central retinal vein occlusion have secondary retinal edema and may have lenticular opacity, higher laser powers may be required to achieve a 100% rupture rate of these structures.
Double-Difference Tomography: The Method and Its Application to the Hayward Fault, California (2003)

We have developed a double-difference (DD) seismic tomography method that makes use of both absolute and relative arrival times. By reducing systematic errors using the more accurate relative arrival times, the method produces an improved velocity model. Simultaneously, it yields event locations of a quality equivalent to those of the DD location method, while avoiding simplifying assumptions of that method. We test this method on a synthetic dataset and find that it produces a more accurate velocity model and event locations than standard tomography. We also test this method on a Hayward fault, California, earthquake dataset spanning 1984–1998. The earthquakes relocated by this method collapse to a thin line along the fault trace, consistent with previous results. The DD velocity model has sharper velocity contrasts near the source region than the standard tomography model.
Bone marrow stromal cells and their use in regenerating bone tissue (2003)

We have used autologous BMSC/bioceramic composites to treat full-thickness gaps of long bones, first in a large animal model (tibia diaphysis in adult sheep) and than in few selected patients. A complete integration of ceramic with bone was observed by X-ray, histology, microradiography and SEM studies. In addition a good functional recovery was obtained. The healing process involved four main steps: 1) bone formation on the outer surface of the implant; 2) bone formation in the inner cylinder canal; 3) formation of fissures and cracks in the implant body (integration and disintegration mechanisms); 4) bone formation in the bioceramics pores. The results obtained are very promising and could represent a real and significant improvement in the repair of critical size long bone defects.
Compact AOP system (2012)

An all-in-one type compact Advanced oxidation process (AOP) system using UV/O3/TiO2 for water purification has been developed. Since all elements are packed in one case, portability and easy installation are facilitated. The ozonizer in this system is newly designed for generating ozone gas just before injection and the extending life time of electrodes. TOC degradation ability is confirmed by using sodium acetate solution. The performance of this AOP system is demonstrated for hydroponics. This system can kill bacteria in fertilizer solution, increase dissolved oxygen and no influence for fertilizer elements. From the results of tomato hydroponic tests, tomato growth using this system is much faster than without the system. It is clearly turned out that this AOP system is suitable for hydroponics.
A comparative study of electrical probe techniques for plasma diagnostics (1972)

Techniques for using electrical probes for plasma diagnostics are reviewed. Specific consideration is given to the simple Langmuir probe, the symmetric double probe of Johnson and Malter, the variable-area probe of Fetz and Oeschsner, and a floating probe technique. The advantages and disadvantages of each technique are discussed.
Calcium carbonate mineralization is essential for biofilm formation and lung colonization (2022)

Biofilms are differentiated microbial communities held together by an extracellular matrix. μCT X-ray revealed structured mineralized areas within biofilms of lung pathogens belonging to two distant phyla - the proteobacteria <i>Pseudomonas aeruginosa</i> and the actinobacteria <i>Mycobacterium abscessus</i>. Furthermore, calcium chelation inhibited the assembly of complex bacterial structures for both organisms with little to no effect on cell growth. The molecular mechanisms promoting calcite scaffold formation were surprisingly conserved between the two pathogens as biofilm development was similarly impaired by genetic and biochemical inhibition of calcium uptake and carbonate accumulation. Moreover, chemical inhibition and mutations targeting mineralization significantly reduced the attachment of <i>P. aeruginosa</i> to the lung, as well as the subsequent damage inflicted by biofilms to lung tissues, and restored their sensitivity to antibiotics. This work offers underexplored druggable targets for antibiotics to combat otherwise untreatable biofilm infections.
Creating a quantum optics interface with topological photonics (Conference Presentation) (2018)

Topological phonics has opened new avenues to designing photonic devices along with opening plethora of applications. Recently even though there has been many interesting studies in topological photonics in classical domain, the quantum regime has still remained largely unexplored. Towards this goal, we developed a topological photonic crystal structure for interfacing single quantum dot spin with photon to realize light matter interaction with topological photonic states. Developed on a thin slab of Gallium Arsenide membrane with electron beam lithography, such a device supports two robust counter-propagating edge states at the boundary of two distinct topological photonic crystals at near-IR wavelength. We show chiral coupling of circularly polarized lights emitted from a single Indium Arsenide quantum dot under strong magnetic field into these topological edge modes. Owing to the topological nature of these guided modes, we demonstrated this photon routing to be robust against sharp corners along the waveguide. Our new technology can pave paths for fault-tolerant photonic circuits, secure quantum computation, exploring unconventional quantum states of light and chiral spin networks.
Effect of Pentaphasic Pulse Sequence as an Impedance Sensor on Standard Electrocardiographic Recordings (1996)

Two advances in cardiac pacing have resulted in an internal conflict in some pacemakers. One is the development of a standard lead physiological sensor and the other is protection from electromagnetic interference (EMI). One popular type of standard lead sensor uses sub-threshold pulses to measure intracardiac and intrathoracic impedance changes, i.e., minute ventilation. Recent clinical observations and extensive in vitro testing have verified that digital cellular phones can be troublesome. Large feedthrough capacitors (FCs), effective in blocking the EMI, will preclude sensing of the standard impedance-based signals. A variety of pulse configurations were studied that might be effective for a sensor-based impedance signal while allowing the pacemaker to continue to use large Fcs protecting them from environmental EMI. In comparison to both monophasic and biphasic pulse sequences, a pentaphasic pulse sequence was effective as an impedance sensor, still allows large FCs to function as an effective filter for environmental EMI, and would not produce artifacts on surface ECG.
Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype (2021)

Steroid regulated cancer cells use nuclear receptors and associated regulatory proteins to orchestrate transcriptional networks to drive disease progression. In primary breast cancer, the coactivator AIB1 promotes estrogen receptor (ER) transcriptional activity to enhance cell proliferation. The function of the coactivator in ER<sup>+</sup> metastasis however is not established. Here we describe AIB1 as a survival factor, regulator of pro-metastatic transcriptional pathways and a promising actionable target. Genomic alterations and functional expression of AIB1 associated with reduced disease-free survival in patients and enhanced metastatic capacity in novel CDX and PDX ex-vivo models of ER<sup>+</sup> metastatic disease. Comparative analysis of the AIB1 interactome with complementary RNAseq characterized AIB1 as a transcriptional repressor. Specifically, we report that AIB1 interacts with MTA2 to form a repressive complex, inhibiting CDH1 (encoding E-cadherin) to promote EMT and drive progression. We further report that pharmacological and genetic inhibition of AIB1 demonstrates significant anti-proliferative activity in patient-derived models establishing AIB1 as a viable strategy to target endocrine resistant metastasis. This work defines a novel role for AIB1 in the regulation of EMT through transcriptional repression in advanced cancer cells with a considerable implication for prognosis and therapeutic interventions.