gebhart/patrepeval huggingface dataset:
Notes on some Copepoda from the Faroe Channel. (1903)

Journal Article Notes on some Copepoda from the Faroe Channel Get access Thomas Scott, LL.D., F.L.S Thomas Scott, LL.D., F.L.S Search for other works by this author on: Oxford Academic Google Scholar Zoological Journal of the Linnean Society, Volume 29, Issue 187, July 1903, Pages 1–11, https://doi.org/10.1111/j.1096-3642.1903.tb00422.x Published: 23 December 2008
Combined Ligand and Structure Based Approaches for Narrowing on the Essential Physicochemical Characteristics for CDK4 Inhibition (2008)

In the absence of an experimentally determined 3D structure of CDK4 (Cyclin-Dependent Kinase 4), QSARs (Quantitative Structure Activity Relationship) have been explored to rationalize binding affinity in terms of physicochemical and structural parameters. Further, docking on a homology model of CDK4 validated the derived QSARs and predicted the binding mode of this series of inhibitors. Relevant parameters and leave-one-out (LOO) cross-validation (q (2)) as well as an external test set validation (r (2) pred) judged the statistical significance and predictive ability of the models. Docking enabled a better understanding of protein-ligand interaction and provided a mechanistic interpretation in terms of physicochemical characteristics. It identified a unique hydrogen bonding between the imidazole of His-95 and the pyridine nitrogen in the ligand. It rationalized the need for R 2 substituents to be bulky and polar, while the substituent at R 8 to be hydrophobic and comparatively less steric. It also explained why at R 6 a variety of substituents are tolerated and how the presence of methyl at R 5 enhances binding affinity.
Structure and Stereochemistry of Pectinolides A-C, Novel Antimicrobial and Cytotoxic 5,6-Dihydro-α-pyrones from Hyptis pectinata (1993)

By bioactivity-directed fractionation, three new antimicrobial and cytotoxic 5,6-dihydro-alpha-pyrones, pectinolides A-C, have been isolated from Hyptis pectinata (Lamiaceae). The absolute stereochemistry of pectinolide A [1] was established as 6S-[(3S-acetyloxy)-1Z-heptenyl]-5S-(acetyloxy)-5 ,6-dihydro-2H-pyran-2-one, on the basis of spectral, chiroptical, and chemical evidence. The structures of pectinolides B [2] and C [3] were determined as the monodeacetylated forms of 1 by comparison of their spectral data and chemical correlation with the prototype compound. Staphylococcus aureus and Bacillus subtilis were sensitive to pectinolide A [1] in the concentration range of 6.25-12.5 micrograms/ml. Compounds 1-3 exhibited significant cytotoxic activity (ED50 < 4 micrograms/ml) against a variety of tumor cell lines.
Monocyte Chemoattractant Protein‐Induced Protein 1 Targets Hypoxia‐Inducible Factor 1α to Protect Against Hepatic Ischemia/Reperfusion Injury (2018)

Sterile inflammation is an essential factor causing hepatic ischemia/reperfusion (I/R) injury. As a critical regulator of inflammation, the role of monocyte chemoattractant protein-induced protein 1 (MCPIP1) in hepatic I/R injury remains undetermined. In this study, we discovered that MCPIP1 downregulation was associated with hepatic I/R injury in liver transplant patients and a mouse model. Hepatocyte-specific Mcpip1 gene knockout and transgenic mice demonstrated that MCPIP1 functions to ameliorate liver damage, reduce inflammation, prevent cell death, and promote regeneration. A mechanistic study revealed that MCPIP1 interacted with and maintained hypoxia-inducible factor 1α (HIF-1α) expression by deubiquitinating HIF-1α. Notably, the HIF-1α inhibitor reversed the protective effect of MCPIP1, whereas the HIF-1α activator compensated for the detrimental effect of MCPIP1 deficiency. Thus, we identified the MCPIP1-HIF-1α axis as a critical pathway that may be a good target for intervention in hepatic I/R injury. (Hepatology 2018; 00:000-000).
Application Integration Platform for an Agile Manufacturing Environment Based on CORBA/AGENT (2006)

A new application integration platform for a manufacturing environment is presented, which is based on agent and common request broker architecture (CORBA). CORBA enhances the system integration because it is an industry-standard for interoperable, distributed objects across heterogeneous hardware and software platforms. Agent technology is used to improve the intelligence of the integration system. The platform is open, distributed, and modular to enable the user to adapt its content to his requirements. This application integration platform supports the goals of agile manufacturing: rapid response to changing requirements, reduction in both time and cost of the product realization process, and integration within a heterogeneous, wide-area-networked enterprise. In order to implement the application integration platform, we use a network integration server to integrate the network; design a generic database agent to integrate application, and utilize a wrapper as a CORBA object to integrate the legacy code. Finally, a prototype framework is developed.
A New, Efficient Exocyclic Amine Protection Scheme for 2-Aminoadenosine and Derivatives for Incorporation into Oligonucleotides (1999)

Abstract We introduce a novel approach to incorporate 2-aminoadenosine into oligonucleotides in which 2-fluoroadenosine and its derivatives are used to prepare the monomers and, under normal oligonucleotide deprotection conditions, is converted to the desired 2-aminoadenosine and derivatives.
A New Soft-Error Phenomenon in VLSIs; The alpha-particle-induced source/drain penetration (ALPEN) effect (1988)

The alpha-particle source/drain penetration (ALPEN) effect is investigated using a 3-D device simulator (CADDETH) and a novel experimental method. A study of soft error due to alpha-particle injection has so far focused on such memory structures and circuits as DRAMs/SRAMs. However, a new soft error is expected to occur in single MOSFETs as the effective channel length becomes comparable to the funneling length. The authors describe: (1) the funneling penetration current between source and drain; (2) a new soft error (0 to 1) caused by the ALPEN effect; (3) experimental verification of the ALPEN effect; and (4) the impact on VLSI scaling. The ALPEN effect puts various constraints, such as the latch-up, emitter-to-collector short in bipolars, and punchthrough in parasitic MOSFETs, on VLSI design. Thus, the ALPEN effect will be a crucial factor in the scaling limits of future ULSIs with dimensions below 0.5 mu m. >
Examination of the association between announced inspections and inspection scores. (2013)

In 2010 the Salt Lake Valley Health Department conducted a pilot of an announced inspection program utilizing a randomized assignment of restaurants to an intervention group with announced inspections and a control group that remained on the usual schedule of unannounced inspections. After adjusting for food type, visible kitchen, outside quality assurance, season, and standardized inspector, significant reductions were found in the odds ratios of personal hygiene (adjusted odds ratios [aOR] = 0.11, p = .00) and equipment cleanliness (aOR = 0.19, p = .00) violations. In the models for the control group, none of the odds ratios were statistically different from one, indicating no change in the postintervention time period as compared to the preintervention period.
Evidence of Electronic Conduction Due to Mixed Osication States in Litetium Diphthalocyanine Films. (1985)

Abstract : This note reports distinctive responses observed on reversal of the Faradaic current in lutetium diphthalocyanine films which provide evidence of electronic conduction due to mixed oxidation states. Implications for reactions of the dye system at high current densities are discussed. Originator-supplied keywords include: Diphthalocyanines; Electronic conduction; Ion transport; and Electrochromism.
Supplementary Table 1 from eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival (2023)

Supplementary Table 1 from eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival
Cued memory decline in biomarker-defined preclinical Alzheimer disease (2017)

Cued memory decline in healthy older adults may be particularly indicative of Aβ-related decline during the preclinical stage of AD and useful for identifying Aβ<sup>+</sup> clinically normal individuals at greatest risk of short-term clinical progression.
Association of ADAM33 gene polymorphisms with allergic asthma. (2014)

Polymorphisms of ADAM33 gene might be associated with severe asthma and sensitivity to aeroallergens in northeast of Iran, but further studies are needed to determine the polymorphisms in this area and other regions of our country.
Nontargeted Screening for Flavonoids in Salicornia Plant by Reversed-Phase Liquid Chromatography–Electrospray Orbitrap Data-Dependent MS2/MS3 (2023)

The Salicornia genus has great potential in agrifood industries because of its nutritional benefits related to its high content of antioxidant compounds, including flavonoids. A nontargeted method based on reversed-phase liquid chromatography-electrospray orbitrap data-dependent MS<sup>2</sup>/MS<sup>3</sup> and the fragment ion search (FISh) strategy was developed to screen flavonoids in Salicornia plants. An extensive study of fragmentation of a set of flavonoid standards allowed for the definition of 15 characteristic fragment ions for flagging flavonoids in the plant matrix. The nontargeted analysis was applied to <i>Salicornia europaea</i> species and allowed for the annotation of 25 candidate flavonoids, including 14 that had not been reported previously. Structural prediction of two unreported flavonoids and their isomeric forms was based on an advanced data processing method using an in silico approach and in-house databases compiling flavonoid-specific chemical substitution. Finally, the method developed allowed for the optimization of extraction yields of flavonoids from the plant matrix.
Optical Measurements of a Lower Calorific Values-Combustor Operated in a Micro Gas Turbine With Various Fuel Compositions (2018)

In a recent joint research project, a new FLOX®-combustion system was developed to couple a fixed-bed gasifier with a micro gas turbine (MGT). Product gases from biomass gasification exhibit low calorific values and varying compositions of mainly H2, CO, CO2, N2, and CH4. Furthermore, combustion characteristics differ significantly compared to the commonly used natural gas. As the FLOX-technology is considered as efficient and fuel-flexible featuring low emissions of hazardous pollutants, the design of the lower calorific value (LCV) combustor is based on it. It contains a two-staged combustor consisting of a jet-stabilized main stage adapted from the FLOX-concept combined with a swirl stabilized pilot stage. The combustor was operated in a Turbec T100 test rig using an optically accessible combustion chamber, which allowed OH*-chemiluminescence and OH-PLIF measurements for various fuel compositions. In particular, the hydrogen content in the synthetically mixed fuel gas was varied from 0% to 30%. The exhaust gas composition was additionally analyzed regarding CO, NOx, and unburned hydrocarbons. The results provide a comprehensive insight into the flame behavior during turbine operation. Efficient combustion and stable operation of the MGT was observed for all fuel compositions, while the hydrogen showed a strong influence. It is remarkable that with hydrogen contents higher than 9%, no OH radicals were detected within the inner recirculation zone, while they were increasingly entrained below hydrogen contents of 9%. Without hydrogen, the inner recirculation zone was completely filled with OH radicals and the highest concentrations were detected there. Therefore, the results indicate a different flame behavior with low and high hydrogen contents. Although the flame shape and position were affected, pollutant emissions remained consistently below 10 ppm based on 15% O2. Only in the case of 0% hydrogen, CO-emissions increased to 43 ppm, which are still meeting the emission limits. Thus, the combustor allows operation with syngases having hydrogen contents from 0% to 30%.
In Memory of Ivo Brosens: Reflections on the Pathophysiology of Neonatal Uterine Bleeding (2023)

Endometrial development and its response to withdrawal of hormones at birth varies and may be affected by intrauterine stressors and gestational age. Factors that affect endometrial development during fetal life and in preterm neonates can have implications on future reproductive performance.
Polar Antenna Impedance Detection and Tuning for Efficiency Improvement in a 3G/4G CMOS Power Amplifier (2014)

An antenna load impedance detection and automatic tuning technique is presented. An antenna load impedance detection circuit as well as burst detector enabling autonomous tuning is integrated on a CMOS-PA chip. A low-loss impedance tuner with an SOI switch is also demonstrated. The proposed impedance detection circuit employs polar detection technique, so that the antenna impedance is tuned in a vector fashion to track the time-varying antenna impedance promptly. Also, it can operate with nonconstant envelope signal thanks to an introduced relative detection technique. At the back-off operation, the impedance can be automatically tuned to optimum value. The circuit is time shared with PA linearization loop, minimizing the overhead of the circuit. When the VSWR is approximately 2.5, the peak PAE is kept more than 40% with tuning, whereas it varies from 28% to 45% without tuning. The linear efficiency without the tuning is 15% as the worst case, while more than 30% of PAE is maintained when the tuning and PA-closed loop are enabled. The drain efficiency at 6 dB back-off is improved from 30% to 40%. The tuner can cover a VSWR of around 6, while achieving a loss ranging from 0.3 to 4.6 dB.
Asymmetries of Sleep Spindles and Beta Activity in Pediatric EEG (1990)

Unilateral suppression of beta activity, unilateral suppression of sleep spindles, and unilateral delta slowing on EEG have not been previously compared regarding accompanying neuroradiological (NR) and clinical neurological (CN) findings in children. We studied EEGs in children under age 10 years with unilateral beta suppression (n = 80), spindle suppression (n = 51) or unilateral delta slowing (n = 49). There were no significant differences between the three groups of abnormal EEGs in their relationships with NR and CN. Unilateral suppression of sleep spindles and beta activity are at least as accurate as focal slowing in lateralizing NR and CN findings.
Mesoporous organosilicas with thiol functionalised pores: multifunctional dendrimers as sacrificial building block and template (2022)

The synthesis of multifunctional poly(amidoamine) (PAMAM)-based dendrimers containing a cleavable disulfide linker within each arm of the dendrimer, together with condensable triethoxysilyl groups on the periphery of the dendrimer, is described. The dendrimers were mixed with 1,4-bis(triethoxysilyl)benzene and subsequently transformed into silsesquioxane gels or periodic mesoporous organosilicas (PMOs) to generate materials with dendrimers covalently embedded within the interior of the silsesquioxane networks. Subsequent treatment of the gels with dithiothreitol enabled the core of the dendrimers to be selectively cleaved at the disulfide site, thus generating thiol functions localised within the pores. The effect of different dendrimer generations on the reactivity of the pendant thiol functions was probed by impregnation with gold salts, which were reduced to obtain gold nanoparticles within the pore networks of the gels and PMOs. The gels yielded polydisperse gold nanoparticles (2 to 70 nm) with dimensions modulated by the generation of the dendrimer, together with well-defined gold/thiolate clusters with Au⋯S distances of 2.3 Å. Such clusters were also observed in the PMO system, together with monodispersed gold nanoparticles with diameters comparable to that of the organised pores in the PMO. The role of surface functionalisation in controlling the formation of gold clusters and/or nanoparticles is discussed.
Glutamine synthesis is a regulatory signal controlling glucose catabolism in Saccharomyces cerevisiae (1993)

The effect of glutamine biosynthesis and degradation on glucose catabolism in Saccharomyces cerevisiae was studied. A wild-type strain and mutants altered in glutamine biosynthesis and degradation were analyzed. Cells having low levels of glutamine synthetase activity showed high ATP/ADP ratios and a diminished rate of glucose metabolism. It is proposed that glutamine biosynthesis plays a role in the regulation of glucose catabolism.
Supplementary Figures from Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy (2023)

Supplementary Figures from Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy
CMOS parametric current amplifier (1996)

The current amplifier presented is based on a gate-bulk-source translinear loop of MOSTs biased in weak inversion. Large gain factors are achieved with the consumption of only a small area. Gain is controlled by a ratio of bias currents.
Determination and Identification of a Specific Marker Compound for Discriminating Shrub Chaste Tree Fruit from Agnus Castus Fruit Based on LC/MS Metabolic Analysis (2016)

Shrub Chaste Tree Fruit (SCTF) is defined as the fruits of Vitex rotundifolia L. f. and V. trifolia L. and has been used as a component of some traditional Japanese medicines (Kampo formulations). Agnus Castus Fruit (ACF) is defined as the dried ripe fruits of V. agnus-castus L.; it is used in traditional European medicines, but is becoming popular in Japan as both an over-the-counter drug and as an ingredient in health foods for treating premenstrual syndrome (PMS). To ensure the efficacy and safety of both SCTF and ACF products, it is important to precisely authenticate their botanical origins and to clearly distinguish between SCTF and ACF. Therefore, we tried to identify SCTF-specific marker compounds based on LC/MS metabolic analysis. The multivariate analysis of LC/MS data from SCTF and ACF samples furnished candidate marker compounds of SCTF. An SCTF-specific marker was isolated from SCTF crude drugs and identified as 3-O-trans-feruloyl tormentic acid on the basis of spectroscopic data from NMR and MS. Since avoiding contamination from closely related species is a significant requirement for pharmaceuticals of natural origin, this information will be valuable for the quality control of both SCTF and ACF products from the viewpoint of regulatory science.
On the use of hidden Markov model to predict the time to fix bugs (2018)

A significant amount of time is spent by software developers in investigating bug reports. It is useful to indicate when a bug report will be closed, since it would help software teams to prioritise their work. Several studies have been conducted to address this problem in the past decade. Most of these studies have used the frequency of occurrence of certain developer activities as input attributes in building their prediction models. However, these approaches tend to ignore the temporal nature of the occurrence of these activities. In this paper, a novel approach using Hidden Markov models (HMMs) and temporal sequences of developer activities is proposed. The approach is empirically demonstrated in a case study using eight years of bug reports collected from the Firefox project. We provide additional details below. In a software bug repository, recorded developer activities occur sequentially. For example, activity C (a certain person has been copied on the bug report) is followed by activity A (bug confirmed and assigned to a named developer), which in turn is followed by activity Z (bug reached status resolved). Additional piece of information is developers' level of expertise, such as novice (N), intermediate (M), or experienced (E), at the time of report creation. We combine these data together to produce a sequence of temporal activities associated with bug reports in the Firefox bug repository.
Editing techniques for MPEG multiplexed streams (1997)

Digital video editing solutions have developed from the stage where they were used to just create nonprofessional, small stamp-size video clips to become an important step in the high end digital broadcast video production process. The authors explore compressed domain editing for MPEG encoded multiplexed streams. They have designed an efficient indexing scheme which accelerates random access and also provides multiple access indices into MPEG streams. They also present an innovative algorithm for editing of MPEG program and transport streams, and for inserting special effects in the compressed domain itself. Finally they present an architecture for a Visual Asset Management System (VAMS) which enhances the functionality of the editing application to provide a complete video archival and management system.
Stress corrosion cracking of candidate waste container materials; Final report (1992)

Six alloys have been selected as candidate container materials for the storage of high-level nuclear waste at the proposed Yucca mountain site in Nevada. These materials are Type 304L stainless steel (SS). Type 316L SS, Incoloy 825, phosphorus-deoxidized Cu, Cu-30%Ni, and Cu-7%Al. The present program has been initiated to determine whether any of these materials can survive for 300 years in the site environment without developing through-wall stress corrosion cracks. and to assess the relative resistance of these materials to stress corrosion cracking (SCC)- A series of slow-strain-rate tests (SSRTs) and fracture-mechanics crack-growth-rate (CGR) tests was performed at 93{degree}C and 1 atm of pressure in simulated J-13 well water. This water is representative, prior to the widespread availability of unsaturated-zone water, of the groundwater present at the Yucca Mountain site. Slow-strain-rate tests were conducted on 6.35-mm-diameter cylindrical specimens at strain rates of 10-{sup {minus}7} and 10{sup {minus}8} s{sup {minus}1} under crevice and noncrevice conditions. All tests were interrupted after nominal elongation strain of 1--4%. Scanning electron microscopy revealed some crack initiation in virtually all the materials, as well as weldments made from these materials. A stress- or strain-ratio cracking index ranks these materials, in order of increasing resistance to SCC, as follows: Type 304 SS < Type 316L SS < Incoloy 825 < Cu-30%Ni < Cu and Cu-7%Al. Fracture-mechanics CGR tests were conducted on 25.4-mm-thick compact tension specimens of Types 304L and 316L stainless steel (SS) and Incoloy 825. Crack-growth rates were measured under various load conditions: load ratios M of 0.5--1.0, frequencies of 10{sup {minus}3}-1 Hz, rise nines of 1--1000s, and peak stress intensities of 25--40 MPa{center_dot}m {sup l/2}.
Benefit of Prime Factor FFTs in Fully Parallel 60 GBaud CDC Filters (2020)

Prime factor algorithms are beneficial in fully parallel frequency-domain implementation of CDC filters and enable a more continuous scaling of filter lengths. ASIC implementation results in 28-nm CMOS for 60 GBd are provided.