gebhart/patrepeval huggingface dataset:
Use of Transient Tests to Monitor Progress of Flooding in IOR / EOR Operations (2016)

Abstract Improved and enhanced oil recovery methods (IOR and EOR, respectively) are used to increase recovery from proven reserves mainly following waterflooding. Monitoring and managing the progress of flood in IOR /EOR operations is currently a challenge to the oil industry especially in situations with large well spacing and cost prohibitive measures like drilling observation wells (e.g., offshore and deep water applications). Falloff tests have been proven successful under waterflooding operations to determine the reservoir properties in various banks around the injection wells and the location of the flood fronts (Abbaszadeh and Kamal 1989, Yeh and Agarwal 1992, and Kamal 2009). In this paper we share new development that extends transient testing and analysis technology to IOR and EOR operations during polymer flooding. With the expanded use of Permanent Downhole Pressure Gauges (PDHG), the new developed technique can be used without additional operational cost or interruption of field operations. In this paper, the effects of polymer are described by shear rate dependent viscosity (non-Newtonian flow). We developed an analytical solution of wellbore pressure by combining the non-Newtonian fluids and the multi-composite reservoir models. The solution dose not only address the polymer region where the fluids follow either the power-law (Ostwald 1929) or the Meter model (Meter and Bird 1964), but also the Newtonian flow in the oil region with varying oil and polymer saturations in both regions. The developed solution was validated by analyzing synthetic data generated using a commercial numerical reservoir simulator. The solution provides a deeper understanding about the physics behind the transient pressure behaviors during polymer flooding, and can be applied to guide a better implementation of well tests. Interpretation method for falloff tests using the new solution and the conventional Bourdet derivative and Horner plots is presented indicating that existing commercial well testing software are sufficient to analyze data with the recent development. The new solution allows us to obtain the reservoir properties such as fluid mobilities in various banks and the location of the flood front. The developed solution was applied to field data. The pressure behavior expected from the new solution was observed in field data validating our developed technique and yielding the characterization of reservoir parameters in various banks. The novelty of this method of characterizing the dynamic properties of the various banks during injection of non-Newtonian fluids and the location of the flood fronts is that an analytical solution of pressure transient behavior in two phase flow of non-Newtonian fluids and Newtonian fluids was developed, validated and used to analyze field data. This is the first analytical solution developed for this type of problem.
P2-164 Human papillomavirus, other sexually transmitted infections and risk of cervical cancer. A Nordic Joint Study (2011)

Introduction Human papillomavirus (HPV) is considered necessary cause of invasive cervical cancer (ICC), but relations between different HPV types and other sexually transmitted infections in cervical carcinogenesis are unresolved. The CCRPB-EU Network conducted a large study, aiming to assess how major high- and low-risk HPV types, 16, 18 and 6, and possible cofactors, Chlamydia trachomatis and herpes simplex virus type 2 (HSV-2), interact in the aetiology of cervical cancer. Methods A case-control study was nested in four Nordic serum banks containing serum samples from approximately 1 000 000 women. Linkage to cancer registries resulted to 604 ICC cases diagnosed after serum sampling. Five controls were matched to bank, age at sampling and storage time. IgG antibodies specific for HPV types, C trachomatis and HSV-2 were determined, and tobacco smoke exposure measured by serum cotinine, and HPV DNA in cancer tissue PCR-tested. ORs were estimated by conditional logistic regression, and adjusted for cotinine and for HPV16, HPV18 and C trachomatis , when applicable. Results Seropositivity for HPV16 did not confer any increased risk for HPV18 DNA positive cancer and HPV18 seropositivity had no association with HPV16 DNA positive cancer. HPV6 had no effect on its own but an antagonistic joint effect with HPV16. HSV-2 had little or no association. C trachomatis had a strongly increased risk for cervical cancer, which remained also among HPV18 seropositives. Conclusions Type-specific HPV DNA persistence is important in cervical carcinogenesis. HSV-2 is possibly not a cofactor, but C trachomatis is probably a strong cofactor for ICC.
Monte Carlo calculations of UV protective properties of emulsions containing TiO 2 , Si and SiO 2 nanoparticles (2007)

In this paper, we investigate the effect of nanoparticles made of different materials, such as titanium dioxide (TiO<sub>2</sub>), silicon (Si), and silica (SiO<sub>2</sub>) on UV protective properties of transparent emulsion used for sunscreens within the range of diameters d=10-200 nm by means of Monte Carlo simulations. As a result, silicon nanoparticles of appropriate sizes are the most protective-efficient within the whole UV spectral range among all kinds of investigated particles. Within one kind of particles, specific sizes are the following. For shorter wavelengths of the considered range (&lambda; = 290 nm) 20-100-nm TiO<sub>2</sub> and 30-100-nm Si particles are the most effective protectors. For longer wavelengths (350 and 400 nm) the most pronounced attenuation is obtained with: a) for Si: d = 40 - 120 nm (&lambda; = 350 nm) and d = 60 - 140 nm-sized (&lambda; = 400 nm) particles, b) for TiO<sub>2</sub>: d = 80 - 160 nm (&lambda; = 350 nm) and d = 120-180 nm-sized (&lambda; = 400 nm) particles. Silica particles are much less protective than those mentioned above due to small refractive index mismatch between them and the surrounding emulsion.
Energy management system for vehicles (2015)

Also published as: CN106428016 (A) CN108369103 (A) EP3104123 (A1) HK1231549 (A1) HK1231550 (A1) US2016363456 (A1) US2018188051 (A1) WO2016198674 (A1)
Effect of Dimethyl Sulfoxide and Melatonin on the Isolation of Human Primary Hepatocytes (2014)

The availability of fully functional human hepatocytes is critical for progress in human hepatocyte transplantation and the development of bioartificial livers and in vitro liver systems. However, the cell isolation process impairs the hepatocyte status and determines the number of viable cells that can be obtained. This study aimed to evaluate the effects of using dimethyl sulfoxide (DMSO) and melatonin in the human hepatocyte isolation protocol. Human hepatocytes were isolated from liver pieces resected from 10 patients undergoing partial hepatectomy. Each piece was dissected into 2 equally sized pieces and randomized, in 5 of 10 isolations, to perfusion with 1% DMSO-containing perfusion buffer or buffer also containing 5 mM melatonin using the 2-step collagenase perfusion technique (experiment 1), and in the other 5 isolations to standard perfusion or perfusion including 1% DMSO (experiment 2). Tissues perfused with DMSO yielded 70.6% more viable hepatocytes per gram of tissue (p = 0.076), with a 26.1% greater albumin production (p < 0.05) than those perfused with control buffer. Melatonin did not significantly affect (p > 0.05) any of the studied parameters, but cell viability, dehydrogenase activity, albumin production, urea secretion, and 7-ethoxycoumarin O-deethylase activity were slightly higher in cells isolated with melatonin-containing perfusion buffer compared to those isolated with DMSO. In conclusion, addition of 1% DMSO to the hepatocyte isolation protocol could improve the availability and functionality of hepatocytes for transplantation, but further studies are needed to clarify the mechanisms involved.
The Generic Interaction Protocol: Increasing portability of distributed physical user interfaces (2013)

Natural user interfaces want to liberate the user from having to learn new concepts to interact with computers. They do that by taking advantage of our senses and our own knowledge about world in order to build the user interface. Physical user interfaces are a prominent example, where physical objects are enhanced to represent actions or information that the system must exchange with the user. One of the main drawbacks of physical user interfaces is often related with the difficulty to decouple system logic from the specific technology used to build the user interface, especially when multiple environments or scenarios should be supported. This paper presents an abstraction technology for user interaction devices that allows the building of physical user interfaces that are physically and logically decoupled from the system logic.
GEOTECHNICAL STRATEGY AND TACTICS AT ANGLO PLATINUM'S PPRUST OPEN PIT OPERATION, LIMPOPO PROVINCE, SOUTH AFRICA (2006)

Over the last four years Potgietersrust Platinums (PPRust) has successfully&#13;\nimplemented new geotechnical strategy and tactics to reduce risk, improving safety but&#13;\nalso maximising profitability. A large database of core logging, face mapping and rock&#13;\ntesting has been assembled and used in the slope design process. The data has also been&#13;\nused for optimising blast designs on a daily basis through the use of a geotechnical&#13;\nblock model. This greatly improves blast fragmentation and therefore loading and&#13;\nmilling efficiencies. Slope management includes a limit blasting programme, daily&#13;\nvisual inspections, and state-of-the-art slope monitoring equipment, namely&#13;\nGroundProbe radar, Riegl lasers and GeoMoS automated prism monitoring. Slope&#13;\noptimisation incorporates all the field data, operational controls, cost of failure, full&#13;\neconomic analysis of various slope angles and fault tree analysis. Savings on waste&#13;\nstripping of hundreds of millions of Rands were gained from the optimisation as slope&#13;\nangles could be increased due to improved geotechnical knowledge and management.&#13;\nPPRust’s geotechnical work is considered the benchmark for Anglo American open pit&#13;\noperations.
Natural products from a filamentous fungal isolate of an unidentified species (2014)

Our ongoing studies of filamentous fungi resulted in the investigation of an isolate of an unidentified species (MSX-19583) that was obtained from spruce litter collected from La Mesa Pass and Cumbres Pass, Colorado. The solid-substrate fermentation cultures of this isolate exhibited cytotoxic activity against MDA-MB-435 human melanoma cells. Chemical separation of this extract afforded a new diketopiperazine dimer, cyclo-(Trp- Phe), S-syndonic acid, and S-sydonol. The groß structures of the secondary metabolites were established using various 1D and 2D NMR techniques. Relative configuration of the new compound was assigned by interpretation of NOESY data in conjuction with the results of Marfey's analysis. Overall absolute configuration of was determined using Marfey's method and comparison of electronic circular dichroism (ECD) data.
The Role of Chemokines in Mediating Graft Versus Host Disease: Opportunities for Novel Therapeutics (2012)

Bone marrow transplantation (BMT) is the current therapy of choice for several malignancies and severe autoimmune diseases. Graft versus host disease (GVHD) is the major complication associated with BMT. T lymphocytes and other leukocytes migrate into target organs during GVHD, become activated and mediate tissue damage. Chemokines are well known inducers of leukocyte trafficking and activation and contribute to the pathogenesis of GVHD. Here, we review the major animal models used to study GVHD and the role of chemokines in mediating tissue damage in these models. The role of these molecules in promoting potential beneficial effects of the graft, especially graft versus leukemia, is also discussed. Finally, the various pharmacological strategies to block the chemokine system or downstream signaling events in the context of GVHD are discussed.
Infrared spectra of the ammonium ion in crystals. Part XII. Low-temperature transitions in ammonium dichromate, (NH4)2Cr2O7 (1982)

Examination of the infrared spectra of the probe ions NH 3 D + and NHD 3 + in ammonium dichromate confirms the existence of the lowest (T tr ~ 125 K) of the three transitions that are known, from nonspectroscopic evidence, to occur in this crystal below room temperature. Below T tr the ammonium ions are of two types, in an abundance ratio of 1:1 and both of symmetry C 1 . Above T tr the probe ion spectra are difficult to interpret in detail. The strength of the hydrogen-bonding interactions covers a wide range, as indicated by the difference between the highest and the lowest values of the isotopically isolated ND stretching frequencies at 10 K, 2392 and 2234 cm −1 .
Kill shot: Flu vaccine is a stone cold cancer killer (2020)

Injection of seasonal influenza vaccine into tumors enhances local and systemic anti-cancer immunity and sensitizes previously resistant tumors to immune checkpoint therapy.
Modiolus-Hugging Intracochlear Electrode Array with Shape Memory Alloy (2013)

In the cochlear implant system, the distance between spiral ganglia and the electrodes within the volume of the scala tympani cavity significantly affects the efficiency of the electrical stimulation in terms of the threshold current level and spatial selectivity. Because the spiral ganglia are situated inside the modiolus, the central axis of the cochlea, it is desirable that the electrode array hugs the modiolus to minimize the distance between the electrodes and the ganglia. In the present study, we propose a shape-memory-alloy-(SMA-) embedded intracochlear electrode which gives a straight electrode a curved modiolus-hugging shape using the restoration force of the SMA as triggered by resistive heating after insertion into the cochlea. An eight-channel ball-type electrode array is fabricated with an embedded titanium-nickel SMA backbone wire. It is demonstrated that the electrode array changes its shape in a transparent plastic human cochlear model. To verify the safe insertion of the electrode array into the human cochlea, the contact pressures during insertion at the electrode tip and the contact pressures over the electrode length after insertion were calculated using a 3D finite element analysis. The results indicate that the SMA-embedded electrode is functionally and mechanically feasible for clinical applications.
MRI Evaluation of Spinal Length and Vertebral Body Angle During Loading with a Spinal Compression Harness (1998)

Weight bearing by the spinal column during upright posture often plays a role in the common problem of low back pain. Therefore, we developed a non-ferromagnetic spinal compression harness to enable MRI investigations of the spinal column during axial loading. Human subjects were fitted with a Nest and a footplate which were connected by adjustable straps to an analog load cell. MRI scans of human subjects (5 males and 1 female with age range of 27-53 yrs) during loaded and unloaded conditions were accomplished with a 1.5 Tesla GE Signa scanner. Studies of two subjects undergoing sequentially increasing spinal loads revealed significant decreases (r(sup 2) = 0.852) in spinal length between T4 and L5 culminating in a 1.5 to 2% length decrease during loading with 75% body weight. Sagittal vertebral body angles of four subjects placed under a constant 50% body weight load for one hour demonstrated increased lordotic and kyphotic curvatures. In the lumbar spine, the L2 vertebral body experienced the greatest angular change (-3 deg. to -5 deg.) in most subjects while in the thoracic spine, T4 angles increased from the unloaded state by +2 deg. to +9 deg. Overall, our studies demonstrate: 1) a progressive, although surprisingly small, decrease in spinal length with increasing load and 2) relatively large changes in spinal column angulation with 50% body weight.
Starting Digital Treatment for Neurodevelopmental Disorders by Experience Experts: On the Waiting List for Diagnostic Assessment via the Super Brains App (2022)

Digital treatment for neurodevelopmental disorders is being developed in order to treat patients online when possible, to reduce waitinglists, and to improve efficiency of treatment. In this workshop, first experiences with the so called Start Programme of the Super Brains app for ADHD in adults are presented. The Super Brains app has been developed by Rutger den Hollander, who himself has ADHD and owns an ICT company in the Netherlands, in cooperation with the speaker of this workshop and Parnassiagroep. The Start Programme is a new part of the Super Brains app, meant for patients referred for treatment that have to wait on often long waitinglists. Now they have no longer to wait, but can start immediately preparing for assessment by filling in questionnaires, and with psycho-education, lifestyle tips and support by experience experts that welcome them in the app and show them around. First data on the use of different parts of the Start Programme, the activity of patients in the app, and the satisfaction of patients will be presented. We also aim to study whether the Start Progamme is effective in reducing severity of ADHD symptoms. Super Brains can be adjusted for use in patients with other (neurodevelopmental) disorders easily. Disclosure No significant relationships.
Effect of 6‐cyano‐2,3‐dihydroxy‐7‐nitro‐quinoxaline (CNQX) on dorsal root‐, NMDA‐, kainate‐ and quisqualate‐mediated depolarization of rat motoneurones in vitro (1990)

1. Mature in vitro rat spinal cord preparations have been used to compare the depressant effects of 6-cyano-2,3-dihydroxy-7-nitroquinoxalinedione (CNQX) and kynurenate on transmission from low threshold myelinated primary afferents in dorsal roots. EC50 values +/- s.e.mean (number of preparations in parentheses) for depression of the monosynaptic ventral root reflex were respectively 1.0 +/- 0.3 microM (5) and 135 +/- 15 microM (3) for CNQX and kynurenate. Transmission through superior cervical ganglia was not significantly affected by concentrations of CNQX up to 100 microM or kynurenate up to 5 mM. 2. Immature in vitro rat spinal cord preparations were used to measure dose-ratios for antagonism of depolarizations induced by N-methyl-D-aspartate (NMDA), kainate or quisqualate by 4, 10 and 25 microM CNQX. In the presence of 0.75 mM Mg2+ pA2 values +/- s.e.mean were respectively 4.62 +/- 0.05 (16), 5.79 +/- 0.01 (4) and 5.59 +/- 0.05 (16) for each agonist. These values were not significantly altered in the absence of added Mg2+. The mean pA2 values for kainate were significantly higher than those for quisqualate (P less than 0.01). 3. Antagonism of NMDA-induced depolarizations was evident at 10 and 25 but not 4 microM CNQX. The antagonism of NMDA was reversed by D-serine (100 and 200 microM). 4. A similarity between the relative potencies of both CNQX and kynurenate for depression of synaptic transmission and antagonism of amino acid-induced depolarizations indicates that monosynaptic transmission from myelinated primary afferents to motoneurones is mediated by kainate and/or quisqualate sub-types of non-NMDA receptors.
Coarse grid correction scheme for implicit multiblock Euler calculations (1995)

A coarse grid correction scheme is used to bring global influence to implicit multiblock calculations. Compared to using only explicit coupling between the blocks, a considerable reduction in the number of time steps needed to reach steady state has been observed for transonic and subsonic flows. The additional CPU time per time step associated with the method is small, resulting in a highly efficient parallel implicit scheme.
Neuroradiology of Tuberous Sclerosis in Children (1974)

A retrospective study of tuberous sclerosis in 45 children aged six months to 14 years was done. Positive neuroradiologic findings were present in all, often before the clinical diagnosis was suspected. Pneumoencephalography revealed definite nodules in almost all cases; mild ventricular dilatation was also a common finding. Children are less likely to have intracranial calcification than adults, but the incidence of these calcifications increases with age.
Data Sharing Across Jurisdictions Using ESSENCE Federated Queries (2016)

A new capability has been developed for ESSENCE systems that allow local administrators to publish their data sources for use by another jurisdiction's ESSENCE users. This presentation will describe the new federated query capability in ESSENCE and how it could affect public health practice in the future. Specifically, this presentation will describe how a federated set of disease surveillance systems across the country could help improve national disease surveillance situational awareness along with its potential to connect non-ESSENCE systems in the future for even more complete coverage.
Cuff-Less and Continuous Blood Pressure Monitoring: A Methodological Review (2017)

Blood pressure (BP) is one of the most important monitoring parameters in clinical medicine. For years, the cuff-based sphygmomanometer and the arterial invasive line have been the gold standards for care professionals to assess BP. During the past few decades, the wide spread of the oscillometry-based BP arm or wrist cuffs have made home-based BP assessment more convenient and accessible. However, the discontinuous nature, the inability to interface with mobile applications, the relative inaccuracy with movement, and the need for calibration have rendered those BP oscillometry devices inadequate for next-generation healthcare infrastructure where integration and continuous data acquisition and communication are required. Recently, the indirect approach to obtain BP values has been intensively investigated, where BP is mathematically derived through the “Time Delay” in propagation of pressure waves in the vascular system. This holds promise for the realization of cuffless and continuous BP monitoring systems, for both patients and healthy populations in both inpatient and outpatient settings. This review highlights recent efforts in developing these next-generation blood pressure monitoring devices and compares various mathematical models. The unmet challenges and further developments that are crucial to develop “Time Delay”-based BP devices are also discussed.
Next-Generation Honeynet Technology with Real-Time Forensics for U.S. Defense (2007)

High-interaction honeynets are extraordinary intrusion intelligence tools. Unfortunately, their power has come at a significant cost. Forensic analysis can be cumbersome and labor intensive, management burdens are often onerous, and compromised honeynets present a risk of being used to stage further attacks. In short, these high-interaction intelligence tools have lacked operational agility. We present a novel approach to honeypot architecture that combines advances in virtualization, low-level introspection, signature generation, and forensic analysis to construct a real-time, high-interaction intrusion intelligence and prevention tool.