gebhart/patrepeval huggingface dataset:
Preparation and characterization of a pentaammineruthenium(III) derivative of horse heart ferricytochrome c. (1982)

A stable complex between pentaammineruthenium(III) and histidine-33 in horse heart ferricytochrome c is formed in the reaction between aquopentaammineruthenium(II) and the protein at pH 7. HPLC of the tryptic hydrolysate of the modified protein was employed to identify the pentaammineruthenium binding site. Spectroscopic measurements show that the integrity of the native structure in the vicinity of the heme c group is maintained in the ruthenium-modified protein. The reduction potentials are: heme c (Fe3+/2+), 0.26 V; Ru(NH3)5(His-33)3+/2+, 0.15 V (vs. normal hydrogen electrode).
Microwave Heating Effects Rapid and Selective Decarboalkoxylation of Mono‐Alkylated Malonates and β‐Ketoesters (2003)

Abstract Brief microwave irradiation of mono‐alkylated malonates and β‐ketoesters at 160–200 °C in wet DMF induces smooth and selective decarboalkoxylation. Observations suggest that this reaction occurs by nucleophilic attack of water at the ester carbonyl carbon (hydrolysis) followed by decarboxylation of the resulting acid. The process occurs despite the absence of traditional acid, base or nucleophile catalysts or reagents.
Antibody‐mediated cell labeling of peripheral T cells with micron‐sized iron oxide particles (MPIOs) allows single cell detection by MRI (2007)

Labeling cells with iron oxide is a useful tool for MRI based cellular imaging. Here it is demonstrated that peripheral rat T cells can be labeled in whole blood, in vitro, with streptavidin-coated micron-sized iron oxide particles (MPIOs), achieving iron concentrations as high as 60 pg iron per cell. This is 30 times the amount of labeling reported with ultrasmall particles of iron oxide (USPIOs). Labeling was mediated by use of a biotinylated anti-CD5 antibody, which is specific for peripheral T cells. Such labeling allowed the in vitro detection of single lymphocytes by MRI, using conditions well suited for in vivo animal work. Electron microscopic analysis demonstrated that MPIOs remained largely extracellular after labeling, with some evidence of intracellular uptake. Cell viability and early and late cytokine release studies showed no significant differences between labeled and unlabeled cells. Therefore, the use of MPIOs for achieving high iron concentrations for cellular MRI is potentially an effective new modality for non-invasive imaging of lymphocytes.
Grating detection and identification dissociated by pattern adaptation (1995)

It two gratings differ in a higher harmonic only, grating identification is expected to depend on that harmonic detection. Yet the comparison of data from several studies suggests that pattern adaptation might differently affect detection and identification. In order to verify this dissociation, a study was made of the effects of adaptation to complex gratings and their harmonics on the detection of the harmonics and on the identification of the complex gratings. Square-wave, first-plus-third-harmonic and missing-fundamental complex gratings were used. The threshold was measured either by the two-interval forced-choice method or by the one-interval method of constant stimuli. For all types of stimuli and procedures, the detection threshold was mostly elevated after adaptation to the corresponding harmonic and the identification threshold was mostly elevated after adaptation to the complex stimulus. This dissociation could only partly be related to the presence of higher harmonics or to the psychophysical procedure. Analysis of threshold changes by adaptation and of phenomenal stimulus appearance suggests that both local features and more global features might contribute to grating identification.
Telework and psychological distance (1999)

Telework is a phenomenon of growing international importance. U.S.-based studies have raised a concern that telework may increase workers' psychological distance from the organization and their Workgroup. This study investigates this proposition. It also explore possible mediating effects of technology infrastructure and national culture on the psychological distancing of the workforce as a result of telework.
In the shell (2004)

Five afternoons a week Jason puts on his grey pants and shirt, walks down his dirt driveway and drags his steel gate open. He walks across the road and magpies squawk on the powerlines above him, while in the distance trucks groan on the Hume Highway...
Topographic Features Retained after Antibiotic Modification of Ti Alloy Surfaces: Retention of Topography with Attachment of Antibiotics (2009)

Periprosthetic infection is increasingly prevalent in orthopaedics with infection rates of 2% to 15% after total hip arthroplasty. To effectively decrease bacterial attachment, colonization, and subsequent development of periprosthetic infection, we previously described a method to covalently bond vancomycin to smooth Ti alloy surfaces. To attach vancomycin, the Ti surface is first passivated to create a fresh oxide layer. Previously, passivation has been achieved with an H2SO4/H2O2 etch that can destroy the topography of the underlying implant. Passivation by hydrothermal aging as well as by H2SO4/H2O2 incubation produced a robust oxide layer, but only hydrothermal aging left the geometry unaltered. These hydrothermally passivated Kirschner wires and smooth or beaded Ti surfaces were chemically coupled with vancomycin. Antibiotic-coupled samples representing all three geometries were uniformly covered with antibiotic, resisted colonization by Staphylococcus aureus for longer than 8 hours, and retained their biocompatibility as assessed by normal attachment and morphology of preosteocytic MLO-A5 cells. Using this technique, we believe it is possible to passivate many complex implant designs/geometries as a first step toward covalent bonding of antibiotics or other bioactive factors.
Micro pillars with thin hydrophobic layer formed on the side walls to prevent cell protrusion toward side wall (2016)

The paper reports on micro pillars with thin fluorocarbon layer formed onto their side walls and the surface of the substrate where the pillars are standing. Since the cell cannot adhere to the fluorocarbon layer, the cultured cells will adhere only to the top of the pillars. Therefore, the traction forces of the cells might be measured without considering their adhering positions. We fabricated micro pillars and formed 60 nm thick CYTOP layer around its side walls and to the surface of silicon substrate. By forming the CYTOP layer around micro pillars, we demonstrated that the numbers of the protruded cells to the gaps around the pillar became a half compared to those without CYTOP.
Expression of glutaminase is upregulated in colorectal cancer and of clinical significance. (2014)

Cancer cells remodel their metabolic programmes to meet the requirements of rapid proliferation. Glutaminase (GLS1) is a mitochondrial enzyme that converts glutamine to glutamate. Our aim was to investigate, for the first time, GLS1 protein expression in colorectal cancer and to evaluate its clinical significance. Immunohistochemical analysis was performed on tissue microarrays containing pairs of cancer and adjacent normal tissues from colorectal cancer patients (n=257). The expression of GLS1 protein in normal colonic tissues and colorectal cancer was measured by western blotting. Proliferation and cell death were evaluated in colorectal cancer cell lines after GLS1 inhibitor treatment. Compared with normal tissues (18.15%), we observed that the expression of GLS1 increased significantly in colorectal cancer (80.24%; P<0.0001) by immunohistochemical analysis, and the elevation of GLS1 protein expression levels in fresh colorectal cancer samples versus normal colonic tissues were also observed by western blotting. Furthermore, GLS1 expression levels were significantly associated with deeper tumour infiltration (P=0.0002), and the pathological pattern of tubular adenocarcinoma (p=0.0008). In addition, treatment with the GLS1 inhibitor suppressed proliferation and induced apoptosis in HT29 and SW480 cell lines. These results suggest that the expression of GLS1 is upregulated and correlates with clinicopathological factors in colorectal cancer. GLS1 exhibits functional importance in colon cancer tumorigenesis. Moreover, GLS1 may serve as a target for colorectal cancer therapy.
Crytanalysis of SAFER (2003)

Abstract. This paper presents several multiset and boomerang attacks on Safer++ up to 5.5 out of its 7 rounds. These are the best known attacks for this cipher and significantly improve the previously known results. The attacks in the paper are practical up to 4 rounds. The methods developed to attack Safer++ can be applied to other substitutionpermutation networks with incomplete diffusion.
Alternative splicing of MLH1 messenger RNA in human normal cells. (1995)

The hMLH1 protein, composed of 756 amino acids, is the human homologue of the bacterial DNA mismatch repair protein MutL, and germ line mutations of the hMLH1 gene have been identified in kindreds with hereditary nonpolyposis colorectal cancer. We have detected three alternatively spliced forms of hMLH1 mRNA in normal lymphocytes and tissues. One of the spliced forms lacks the coding region of hMLH1 from codons 227 to 295 and the two other transcripts are predicted to encode two truncated proteins retaining the 264 and 226 N-terminal amino acids of hMLH1, respectively. The biological significance of this alternative splicing remains to be established.
Sulforhodamine B and exogenous surfactant effects on alveolar surface tension under acute respiratory distress syndrome conditions (2020)

In the acute respiratory distress syndrome (ARDS), alveolar surface tension, <i>T</i>, may be elevated. Elevated <i>T</i> should increase ventilation-induced lung injury. Exogenous surfactant therapy, intended to lower <i>T</i>, has not reduced mortality. Sulforhodamine B (SRB) might, alternatively, be used to lower <i>T</i>. We test whether substances suspected of elevating <i>T</i> in ARDS raise <i>T</i> in the lungs and test the abilities of exogenous surfactant and SRB to reduce <i>T</i>. In isolated rat lungs, we micropuncture a surface alveolus and instill a solution of a purported <i>T-</i>raising substance: control saline, cell debris, secretory phospholipase A<sub>2</sub> (sPLA<sub>2</sub>), acid, or mucins. We test each substance alone; with albumin, to model proteinaceous edema liquid; with albumin and exogenous surfactant; and with albumin and SRB. We determine <i>T</i> in situ in the lungs by combining servo-nulling pressure measurement with confocal microscopy and applying the Laplace relation. With control saline, albumin does not alter <i>T</i>, additional surfactant raises <i>T</i>, and additional SRB lowers <i>T.</i> The experimental substances, without or with albumin, raise <i>T.</i> Excepting under aspiration conditions, addition of surfactant or SRB lowers <i>T</i>. Exogenous surfactant activity is concentration and ventilation dependent. Sulforhodamine B, which could be delivered intravascularly, holds promise as an alternative therapeutic.<b>NEW & NOTEWORTHY</b> In the acute respiratory distress syndrome (ARDS), lowering surface tension, <i>T</i>, should reduce ventilation injury yet exogenous surfactant has not reduced mortality. We show with direct <i>T</i> determination in isolated lungs that substances suggested to elevate <i>T</i> in ARDS indeed raise <i>T</i>, and exogenous surfactant reduces <i>T.</i> Further, we extend our previous finding that sulforhodamine B (SRB) reduces <i>T</i> below normal in healthy lungs and show that SRB, too, reduces <i>T</i> under ARDS conditions.
Immunonephelometric quantification of group-specific component protein in patients with acute liver failure (1997)

Serum levels of group-specific component (Gc) protein are useful in evaluating the likelihood of survival in patients with acute liver failure (ALF) who may be candidates for liver transplant surgery. Most methods for quantifying Gc protein concentration are either isotopic, manual, technically demanding, and/or time consuming to perform, and thus are not well suited for routine clinical use in a hospital setting. We modified and evaluated a recently described nonisotopic, fully automated, immunonephelometric method for quantifying serum Gc protein concentration and compared it to our previous immunoblotting method. In addition, we evaluated the effect of G-actin on the immunonephelometric measurement of Gc protein. Serum samples from 20 patients with ALF and from 20 age- and sex-matched clinic patients without liver disease were quantified by both immunoblotting and immunonephelometry. We assessed the intra-assay precision, correlation, and diagnostic accuracy of these methods in discriminating between individuals with no preexisting liver disease and those with ALF. Actin in 1.3- to 4-fold excess of Gc protein levels demonstrated minimal to no interference in the quantification of Gc protein by immunonephelometry. Immunonephelometry was more precise than immunoblotting. Gc protein values by immunonephelometry were similar to those obtained by immunoblotting, and the diagnostic accuracy of Gc protein concentration by immunonephelometry was similar to that observed by immunoblotting. Immunonephelometry provides a nonisotopic, fully automated, rapid, precise, accurate, and cost-effective method for quantifying serum levels of total Gc protein that is well suited for routine use in a hospital-based clinical laboratory.
Seroprevalence of Human Herpesvirus 8 among Injection Drug Users in San Francisco (2003)

The association between injection drug use and human herpesvirus 8 (HHV-8) was examined to investigate bloodborne transmission of the virus. In all, 1905 injection drug users (IDUs) enrolled in a cross-sectional study were tested for K8.1 antibodies to HHV-8 lytic antigen. Logistic regression was used to adjust for demographic and sexual behavior variables. HHV-8 seroprevalence was 10% among women, 10% among heterosexual men, and 23% among men who have sex with men. In adjusted analyses, HHV-8 seroprevalence increased with longer duration of injection drug use for each of these groups (P = .01, P = .03, and P = .049 for trend, respectively). HHV-8 infection is relatively common among IDUs in San Francisco, and longer duration of injection drug use is associated with an increase in the risk of HHV-8 infection that is not explained by sexual behavior or demographic differences. These results are consistent with the occurrence of bloodborne transmission of HHV-8 among IDUs.
Image halftoning using a visual model in error diffusion (1993)

Continued advances in binary image printers have spurred an increased interest in the use of digital image halftoning to generate low-cost images that have the appearance of gray levels. However, at current print resolutions for desktop applications, i.e., 300–400 dots/in. (dpi), the binary noise resulting from halftoning is clearly visible at normal viewing distances. Halftoning algorithms that reduce the visibility of this noise result in smoother gray levels and higher-quality output images. We introduce a new method of gray-level image halftoning that uses visual modeling within the framework of error diffusion to improve the image quality of halftoned images.
Forensics Analysis from Cloud Storage Client Application on Proprietary Operating System (2016)

Increased use of cloud storage services have become a necessity alternative that complements the main storage media in everyday activities because it offers ease of doing automatic backups, sharing files and photos and so forth on a variety of computing devices and smartphones. It is very possible loopholes for criminals to store illegal files or matters relating to such activities. There are various types of cloud services with each type having a different potential use in criminal activities. One area of difficulty is the identification and acquisition of potential data when different services can be exploited by criminals. Because geographically cloud servers scattered in various regions. This causes difficulties for digital forensic investigators will add time and expense, to contact all potential service providers to determine whether the data stored in the server cloud services. This paper presented at a target on the client side user application to help find the data renmant on the use of cloud storage applications of various service provider on the proprietary operating system focuses on the Windows 10 platform. Results from this research include a variety of state after the install, deleted and uninstall web browser and memory, in order to find digital evidence. Based on the test results the success index average was 82.63% and the remaining can not be analyzed, the results depend on various state, procedures and tools that are used, the research can be carried out smoothly.
Super-resolution technology to simultaneously improve optical & digital resolution of optical coherence tomography via deep learning (2020)

Optical coherence tomography (OCT) has stimulated a wide range of medical image-based diagnosis and treatment. In cardiac imaging, OCT has been used in assessing plaques before and after stenting. While needed in many scenarios, high resolution comes at the costs of demanding optical design and data storage/transmission. In OCT, there are two types of resolutions to characterize image quality: optical and digital resolutions. Although multiple existing works have heavily emphasized on improving the digital resolution, the studies on improving optical resolution or both resolutions remain scarce. In this paper, we focus on improving both resolutions. In particular, we investigate a deep learning method to address the problem of generating a high-resolution (HR) OCT image from a low optical and low digital resolution (L<sup>2</sup>R) image. To this end, we have modified the existing super-resolution generative adversarial network (SR-GAN) for OCT image reconstruction. Experimental results from the human coronary OCT images have demonstrated that the reconstructed images from highly compressed data could achieve high structural similarity and accuracy in comparison with the HR images. Besides, our method has obtained better denoising performance than the block-matching and 3D filtering (BM3D) and Denoising Convolutional Neural Networks (DnCNN) denoising method.
Spin states in iron(III) phthalocyanines studied by Moessbauer, magnetic susceptibility, and ESR measurements (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpin states in iron(III) phthalocyanines studied by Moessbauer, magnetic susceptibility, and ESR measurementsBrendan J. Kennedy, Keith S. Murray, Peter R. Zwack, Heinrich Homborg, and Winfried KalzCite this: Inorg. Chem. 1986, 25, 15, 2539–2545Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/ic00235a011https://doi.org/10.1021/ic00235a011research-articleACS PublicationsRequest reuse permissionsArticle Views862Altmetric-Citations83LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Quantum railroads: Introducing directionality to Anderson localization (1993)

We present a theory of electron transport in novel disordered waveguides that support different numbers N and M of modes propagating in opposite directions, i.e., ``quantum railroads'' (QRR). Anderson localization and the integer quantum Hall effect are special cases of our theory. More generally, our analytic results based on scattering matrix theory and our numerical simulations show that disorder results in directed localization in QRR's. The limiting transmittance of a macroscopic QRR is T=\ensuremath{\Vert}N-M\ensuremath{\Vert} in the majority direction but T'=0 in the minority direction.
Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease (2020)

Our findings identify targetable mitochondrial features of T2D and NAFLD and highlight the benefit of insulin sensitization in managing the clinical burden of obesity-associated disease.
Alpha-Human Atrial Natriuretic Peptide (α-hANP) Prevents Pulmonary Edema Induced by Arachidonic Acid Treatment in Isolated Perfused Lung from Guinea Pig (1987)

Protective effect of α-human atrial natriuretic peptide (α-hANP) on pulmonary edema was investigated using an isolated perfused lung model. Infusion of α-hANP (1.7 to 22 ng/ml or 0.56 to 7.3 nM) prevented the edema induced in isolated lung from guinea pig by repeated treatment of 50 jug of arachidonic acid at 30 min intervals via the pulmonary artery. The antiedematic action of α-hANP was considered to be receptor mediated because the effective concentration was close to the Kd value of the binding of the ANP receptors in the lung homogenate.
Approximation algorithms for NEXTtime-hard periodically specified problems and domino problems (1996)

We study the efficient approximability of two general class of problems: (1) optimization versions of the domino problems studies in [Ha85, Ha86, vEB83, SB84] and (2) graph and satisfiability problems when specified using various kinds of periodic specifications. Both easiness and hardness results are obtained. Our efficient approximation algorithms and schemes are based on extensions of the ideas. Two of properties of our results obtained here are: (1) For the first time, efficient approximation algorithms and schemes have been developed for natural NEXPTIME-complete problems. (2) Our results are the first polynomial time approximation algorithms with good performance guarantees for `hard` problems specified using various kinds of periodic specifications considered in this paper. Our results significantly extend the results in [HW94, Wa93, MH+94].
ChemInform Abstract: PREPARATION AND CHARACTERIZATION OF SOME CHROMIUM(III) COMPLEXES OF THE FORMS (CR(L‐ OR D‐ASP)(L‐HIS)) AND (CR(L‐ASP)2)‐ (ASP = ASPARTATE AND HIS = HISTIDINATE IONS) (1982)

Abstract K 2 Cr 2 (SO 4 ) 4 in konzentrierter NH 3 ‐Lösung, L‐Aspartinsäure und L‐Histidin reagieren zu einem Isomerengemisch des im Titel genannten Gemischtligand‐Komplexes.
Wide-Area Actuator RPC over GridStat with Timeliness, Redundancy, and Safety (2010)

GridStat is a QoS-managed middleware framework designed to replace the power grid's aging, inflexible, and slow data communications system. GridStat is a specialization of the publish-subscribe paradigm that takes advantage of the semantics of periodic updates of cached sensor data to provide data delivery with a per-subscriber rate, latency, and redundant paths. While GridStat is well-suited for delivery of sensor data over a wide-area network, its baseline one-way mechanisms are not suitable for round-trip invocations such as setting an actuator or calling between control centers. In this paper we present the design, implementation and experimental evaluation of Ratatoskr, a tunable remote procedure call mechanism that builds on the QoS semantics of GridStat and supports three kinds of redundancy. Additionally, user-defined pre- and post-condition predicates over GridStat status variables are built into the call semantics.