gebhart/patrepeval huggingface dataset:
Inhibitory Mechanism of Polyphenol Compounds Isolated from Red Wine on Catecholamine Release in the Perfused Rat Adrenal Medulla (2008)

The present study was designed to examine effects of polyphenolic compounds isolated from red wine (PCRW) on the release of catecholamines (CA) from the isolated perfused model of the rat adrenal medulla, and to clarify its mechanism of action. PCRW (20<TEX>${\sim}$</TEX>180 <TEX>${\mu}$</TEX>g/mL), given into an adrenal vein for 90 min, caused inhibition of the CA secretory responses evoked by ACh (5.32 mM), high <TEX>$K^+$</TEX> (a direct membrane-depolarizer, 56 mM), DMPP (a selective neuronal nicotinic <TEX>$N_N$</TEX> receptor agonist, 100 <TEX>${\mu}$</TEX>M) and McN-A-343 (a selective muscarinic <TEX>$M_1$</TEX> receptor agonist, 100 <TEX>${\mu}$</TEX>M) in dose- and time-dependent fashion. PCRW itself did not affect basal CA secretion (data not shown). Following the perfusion of PCRW (60 <TEX>${\mu}$</TEX>g/mL), the secretory responses of CA evoked by Bay-K-8644 (a L-type dihydropyridine <TEX>$Ca^{2+}$</TEX> channel activator, 10 <TEX>${\mu}$</TEX>M), cyclopiazonic acid (a cytoplasmic <TEX>$Ca^{2+}$</TEX>-ATPase inhibitor, 10 <TEX>${\mu}$</TEX>M) and veratridine (an activator of voltage-dependent <TEX>$Na^+$</TEX> channels, 10 <TEX>${\mu}$</TEX>M) were also markedly blocked, respectively. Interestingly, in the simultaneous presence of PCRW (60 <TEX>${\mu}$</TEX>g/mL) and L-NAME (a selective inhibitor of NO synthase, 30 <TEX>${\mu}$</TEX>M), the inhibitory responses of PCRW on the CA secretion evoked by ACh, high <TEX>$K^+$</TEX>, DMPP, McN-A-343, Bay-K-8644 and cyclpiazonic acid were recovered to considerable level of the corresponding control release compared with those effects of PCRW-treatment alone. Practically, the amount of NO released from adrenal medulla after loading of PCRW (180 <TEX>${\mu}$</TEX>g/mL) was significantly increased in comparison to the corresponding basal released level. Collectively, these results obtained here demonstrate that PCRW inhibits the CA secretory responses evoked by stimulation of cholinergic (both muscarinic and nicotinic) receptors as well as by direct membrane-depolarization from the isolated perfused adrenal gland of the normotensive rats. It seems that this inhibitory effect of PCRW is mediated by blocking the influx of both ions through <TEX>$Na^+$</TEX> and <TEX>$Ca^+{2$}</TEX> channels into the rat adrenomedullary chromaffin cells as well as by inhibiting the release of <TEX>$Ca^{2+}$</TEX> from the cytoplasmic calcium store, which are due at least partly to the increased NO production through the activation of nitric oxide synthase. Based on these data, it is also thought that PCRW may be beneficial to prevent or alleviate the cardiovascular diseases, such as hypertension and angina pectoris.
4.2: Design ofanlmproved Pixel fora Polysilicon Active‐Matrix Organic LED Display (1998)

Abstract A polysilicon transistor based active matrix organic light emitting diode (AMOLED) pixel with high pixel to pixel luminance uniformity is reported. The new pixel powers the OLEDS with small constant currents to ensure consistent brightness and extended life. Excellent pixel to pixel current drive uniformity is obtained despite the threshold voltage variation inherent in polysilicon transistors. considerations in the design for high information content displays are discussed.
The clinical impact of absolute lymphocyte count in peripheral blood among patients with methotrexate - associated lymphoproliferative disorders (2020)

Regressive lymphoproliferative disorders (R-LPD) after methotrexate (MTX) withdrawal are one of the specific features of methotrexate - associated lymphoproliferative disorders (MTX-LPD). Although the impact of the absolute lymphocyte count (ALC) on the pathogenesis of R-LPD has been recently emphasized, understanding relapse/regrowth events (RRE) and differences among LPD subtypes is necessary. In this study, we confirmed ALC recovery in the regressive group (R-G; R-LPD without RRE) and relapse/regrowth group (R/R-G; R-LPD with RRE). The increase in ALC lasted at least 2 years in R-G, whereas it decreased within 3 years in R/R-G, supporting the better overall survival (OS) in R-G, as previously reported. In addition, our study suggested that an ALC of 1000/µL at the time of development of LPD is a significant predictor for treatment-free survival (TFS). Furthermore, an ALC of 1000/µL at 6 months after MTX withdrawal was found to be a significant indicator of TFS and OS for R-G and R/R-G. The ALC decreased gradually before LPD development in R/R-G, whereas it decreased 6 months before LPD development in R-G, confirming the important role of ALC in the pathogenesis of MTX-LPD such as regressive events and RRE. In addition to ALC, other predictive factors, such as serum C-reactive protein and soluble interleukin-2 receptors, may be helpful in the management of MTX-LPD, including the decision making for an additional chemotherapy for regressive LPD after MTX withdrawal.
LA ESTIMACION DEL BANCO DE SEMILLAS DE SUELOS AGRICOLAS. PREMISAS METODOLOGICAS EN EL MUESTREO (1996)

La tecnica de analisis del banco de semillas de suelos agricolas tiene interes en malherbologia en rela­ ci6n con el estudio de los procesos demograficos de malas hierbas, los cuales tienen una especial signi~ ficacion a la hora de adoptar y planificar estrategias de control. La informacion que tanto cualitativa como cuantitativamence puede aportar el banco de semillas sobre la flora potencial, no es actualmente del todo aprovechable debido a restricciones de tipo metodologico relacionadas con el muestreo y la fiabilidad de los valores estudiados. La heterogeneidad en la distribucion espacial de las semillas del suelo. asi como su gran diversidad desde el punto de vista floristico, hace dificil encontrar un metodo de muestreo y analisis adecuado al conjunto. En este sentido y para una adecuada cuantificacion. a menudo los estimadores estadisticos clasicos se revelan insuficientes o bien dificiles de manejo. Desde el ano 1988 un grupo de trabajo de la EWRS esta investigando con el objetivo de conseguir un meto­ do global y rapido de cuantificar el banco de semillas del suelo tanto en el aspecto practico del analisis de muestras como en el analisis estadistico de los resultados. Las restricciones metodologicas que con­ lleva este segundo aspecto y su adecuaci6n a dicha tecnica de analisis son discutidos en el presente arti­ culo.
LPP EUV conversion efficiency optimization (2005)

Efficient conversion of laser light into EUV radiation is one of the most important problems of the laser-produced plasma (LPP) EUV source. Too low a conversion efficiency (CE) increases the amount of power the drive laser will have to deliver, which, besides the obvious laser cost increase, also increases the thermal load on all the components and can lead to increased debris generation. In order to meet the requirements for a high-volume manufacturing (HVM) tool and at the same time keep the laser power requirements within acceptable limits, a CE exceeding 2.5% is likely to be required. We present our results on optimizing conversion efficiency of LPP EUV generation. The optimization parameters include laser wavelength, target material, and laser pulse shape, energy and intensity. The final choice between parameter sets that leads to the required minimum CE is dependent on the debris mitigation solutions and the laser source available for a particular parameter set.
Pterostilbene increases MTA1-mediated p53 acetylation in Du145 cells. (2015)

&lt;p&gt;Du145-EV and Du145-MTA1shRNA cells (&lt;a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057542#pone.0057542.s001" target="_blank"&gt;Fig. S1&lt;/a&gt;) were treated with 50 µM of Res or PTER for 24 hr and analyzed for MTA1, p53, Ac-p53 by Western blot as described in “&lt;a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0057542#s2" target="_blank"&gt;Materials and methods&lt;/a&gt;”. A representative blot is shown. Quantitation of Ac-p53/p53 ratio was conducted by Image J software and data shown as mean±SEM from three independent experiments.&lt;/p&gt;
Efficacy and safety of Canagliflozin (CANA), an inhibitor of Sodium Glucose Co-Transporter 2 (SGLT2), added on to insulin therapy with or without oral agents in type 2 diabetes (T2D) (2013)

Question: SGLT2 inhibition is a novel treatment modality for T2D. We report here a pre-specified substudy of the CANagliflozin cardioVascular Assessment Study (CANVAS) defining the efficacy and safety of CANA in subjects with T2D on insulin.
VLSI Implementation of the Multistage Detector for Next Generation Wideband CDMA Receivers (2006)

The multistage detection algorithm has been proposed as an effective interference cancellation scheme for next generation Wideband Code Division Multiple Access (W-CDMA) base stations. In this paper, we propose a real-time VLSI implementation of this detection algorithm in the uplink system, where we have achieved both high performance in interference cancellation and computational efficiency. When interference cancellation converges, the difference of the detection vectors between two consecutive stages is mostly zero. Under the assumption of BPSK modulation, the differences between the bit estimates from consecutive stages are 0 and ±2. Bypassing the zero terms saves computations. Multiplication by ±2 can be easily implemented in hardware as arithmetic shifts. However, the convergence of the algorithm is dependent on the number of users, the interference and the signal to noise ratio and hence, the detection has a variable execution time. By using just two stages of the differencing detector, we achieve predictable execution time with performance equivalent to at least eight stages of the regular multistage detector. A VLSI implementation of the differencing multistage detector is built to demonstrate the computational savings and the real-timeperformancepotential. The detector, handling up to eight users with 12-bit fixed point precision, was fabricated using a 1.2 μm CMOS technology and can process 190 Kbps/user for 8 users.
Chemically Assisted Directed Assembly of Carbon Nanotubes for the Fabrication of Large-Scale Device Arrays (2007)

We report the directed assembly of single-walled carbon nanotubes (SWCNTs) at lithographically defined positions on gate oxide surfaces, allowing for the high yield ( approximately 90%) and parallel fabrication of SWCNT device arrays. SWCNTs were first chemically functionalized through diazonium chemistry with a hydroxamic acid end group that both renders the SWCNTs water-soluble and discriminately binds the SWCNTs to basic metal oxide surfaces (i.e., hafnium oxide (HfO2)). The functionalized SWCNTs are then assembled from an aqueous solution into narrow trenches etched into SiO2 films with HfO2 at the bottom. The side walls of the patterned trenches induce alignment of the SWCNTs along the length of the trenches. Heating the structures to 600 degrees C removes the organic moieties, leaving pristine SWCNTs as evidenced by Raman spectroscopy and electrical measurements. Palladium source-drain electrodes deposited perpendicular to the trench length readily contact the ends of the aligned SWCNTs. The resultant devices exhibit the electrical performance expected for SWCNT devices, with no performance deterioration as a result of the placement process. This technique allows for the directed assembly and alignment of SWCNTs over a large area and results in a high yield of working devices, presenting a promising path toward large-scale SWCNT device integration.
Frontotemporal dementia: impact of P301L tau mutation on a healthy carrier (2004)

Frontotemporal dementia (FTD) is the second commonest form of dementia after Alzheimer's disease, but its clinical and biological features are less well known. To uncover its earliest signs, we studied the main clinical, neuroimaging, and biochemical findings in an asymptomatic carrier from a three generation FTD family, bearing the P301L pathogenic mutation in the tau gene. Except for selective impairment on the Verbal Fluency Test for letters, all cognitive tests were normal. The brain computed tomography scan was normal, but the brain single photon emission computed tomography and statistical parametric mapping (SPECT-SPM) scan revealed bilateral frontal lobe hypoperfusion. Levels of total tau, 181P-tau, and Abeta1-42 in the cerebrospinal fluid were increased compared with control values. We conclude that detection of these distinctive abnormalities should improve early diagnostic accuracy for FTD and help distinguish it from Alzheimer's disease.
Comparative physical, mechanical and crystallographic properties of a series of gemfibrozil salts (2010)

The type of counter ion is important in determining mechanical properties and could be selected to afford slip and plastic deformation.
Shishaldin Volcano: Aleutian high-alumina basalts and the question of plagioclase accumulation (1991)

Research Article| March 01, 1991 Shishaldin Volcano: Aleutian high-alumina basalts and the question of plagioclase accumulation John Fournelle; John Fournelle 1Department of Earth and Planetary Sciences, Johns Hopkins University, Baltimore, Maryland 21218 Search for other works by this author on: GSW Google Scholar Bruce D. Marsh Bruce D. Marsh 1Department of Earth and Planetary Sciences, Johns Hopkins University, Baltimore, Maryland 21218 Search for other works by this author on: GSW Google Scholar Author and Article Information John Fournelle 1Department of Earth and Planetary Sciences, Johns Hopkins University, Baltimore, Maryland 21218 Bruce D. Marsh 1Department of Earth and Planetary Sciences, Johns Hopkins University, Baltimore, Maryland 21218 Publisher: Geological Society of America First Online: 02 Jun 2017 Online ISSN: 1943-2682 Print ISSN: 0091-7613 Geological Society of America Geology (1991) 19 (3): 234–237. https://doi.org/10.1130/0091-7613(1991)019<0234:SVAHAB>2.3.CO;2 Article history First Online: 02 Jun 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Search Site Citation John Fournelle, Bruce D. Marsh; Shishaldin Volcano: Aleutian high-alumina basalts and the question of plagioclase accumulation. Geology 1991;; 19 (3): 234–237. doi: https://doi.org/10.1130/0091-7613(1991)019<0234:SVAHAB>2.3.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGeology Search Advanced Search Abstract High-alumina basalts (HABs) from volcanic arcs commonly contain 30%-50% (modal) plagioclase. It has been suggested that they reflect plagioclase addition and are not primary compositions. In rocks from the Aleutian volcano Shishaldin, we search for evidence of plagioclase accumulation: A12O3, CaO, and Na2O vs. modal plagioclase; europium anomalies in HABs; plagioclase-liquid equilibrium; and the HAB groundmass. The HABs do not appear to be results of plagioclase addition to liquids of dacitic, Fe-Ti-enriched, or high-Mg basaltic compositions. Plagioclase loss from HABs does appear to yield the Fe-Ti-enriched basalts. Shishaldin HABs may reflect near-primary compositions, and HAB phase equilibria may thus be useful in evaluating the origin of such are basalts. This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
Supplementary Data from Imaging Mass Spectrometry of a Specific Fragment of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Kinase 2 Discriminates Cancer from Uninvolved Prostate Tissue (2023)

Supplementary Data from Imaging Mass Spectrometry of a Specific Fragment of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Kinase 2 Discriminates Cancer from Uninvolved Prostate Tissue
Bifurcations to chaos in optical bistability (1982)

The details of the time-dependent output from a hybrid optical bistable device are investigated in the regime where the delay time of the feedback signal is much larger than the response time of the device (determined by electrical bandwidth of the feedback loop). The delayed feedback is produced by placing a computer equipped with fast $A\ensuremath{-}D$ and $D\ensuremath{-}A$ converters in the feedback loop. This bistable system exhibits periodic and chaotic instabilities as predicted by Ikeda. In particular, as the input intensity is increased, the device output goes through a series of bifurcations (second-order nonequilibrium phase transitions). First, the initially stable output changes to a periodic output (a square wave) followed by a second periodic region whose period is twice that of the previous region. Up to this point, the system behavior is in agreement with the period-doubling scheme of Feigenbaum. However, the period doubling which is predicted next is only rarely observed. Instead the system usually goes over into chaotic behavior. Within the chaotic region, the device largely follows the reverse bifurcation scheme of Lorenz. In addition, there is a small domain of frequency-locked behavior that exists within the chaotic domain. These bifurcations are not only of fundamental interest but may find applications in practical optical devices.
Strongly increased efficiency of altered peptide ligands by mannosylation (1998)

Altered peptide ligands (APL) have the potential to modulate pathogenic T cell reactivity. High concentrations of APL, however, are required to achieve efficient blocking of the T cell response. We have therefore investigated whether improved delivery of APL to professional antigen-presenting cells (APC) can lead to more efficient application of such peptides. For this purpose APL were bis-mannosylated in order to facilitate their uptake by mannose receptor-positive dendritic cells (DC) in vitro. We present evidence that a 100- to 1000-fold lower concentration of bis-mannosylated APL was sufficient for complete blocking of the proliferative T cell response against the agonist peptide compared to the non-mannosylated APL. Moreover, bis-mannosylated APL were similarly effective in the inhibition of the T cell response against whole protein antigens. In contrast, unrelated, bis-mannosylated class II binding peptides were ineffective, indicating that the increased efficiency of the mannosylated APL was not due to competition for binding to class II molecules. Furthermore, a strong increase in the efficiency of presentation of APL was also observed when macrophages and peripheral blood mononuclear cells were used as APC. Thus, bis-mannosylation of APL greatly increases their potency to inhibit proliferative T cell responses. Moreover, it is likely that the use of bis-mannosylated APL will result in preferential presentation by mannose receptor-positive, professional APC. These results may be of relevance for more effective use of APL for immunoregulation in vivo.
Tolerance Induction by Exosomes from Immature Dendritic Cells and Rapamycin in a Mouse Cardiac Allograft Model (2012)

Combined with immunosuppressive treatment, donor imDex can prolong cardiac allograft survival and induce donor specific allograft tolerance.
A Precise and Expressive Lattice-theoretical Framework for Efficient Network Verification (2019)

Network verification promises to detect errors, such as black holes and forwarding loops, by logically analyzing the control or data plane. To do so efficiently, the state-of-the-art (e.g., Veriflow) partitions packet headers with identical forwarding behavior into the same packet equivalence class (PEC).Recently, Yang and Lam showed how to construct the minimal set of PECs, called atomic predicates. Their construction uses Binary Decision Diagrams (BDDs). However, BDDs have been shown to incur significant overhead per packet header bit, performing poorly when analyzing large-scale data centers. The overhead of atomic predicates prompted ddNF to devise a specialized data structure of Ternary Bit Vectors (TBV) instead.However, TBVs are strictly less expressive than BDDs. Moreover, unlike atomic predicates, ddNF's set of PECs is not minimal. We show that ddNF's non-minimality is due to empty PECs. In addition, empty PECs are shown to trigger wrong analysis results. This reveals an inherent tension between precision, expressiveness and performance in formal network verification.Our paper resolves this tension through a new lattice-theoretical PEC-construction algorithm, # PEC, that advances the field as follows: (i) # PEC can encode more kinds of forwarding rules (e.g., ip-tables) than ddNF and Veriflow, (ii) # PEC verifies a wider class of errors (e.g., shadowed rules) than ddNF, and (iii) on a broad range of real-world datasets, # PEC is 10\times faster than atomic predicates. By achieving precision, expressiveness and performance, this paper answers a longstanding quest that has spanned three generations of formal network analysis techniques.
Random transverse tomography and phase‐conjugate scanning for image acquisition through a multimode fiber (1996)

A monochromatic optical field carrying an image is known to be scrambled due to propagation through a multimode fiber. Two schemes of the image acquisition through such a fiber are suggested. Both are based on the assumption that the input-to-output propagation Green function is stabilized by some technique. In both schemes the object is characterized by the transverse distribution of reflection pattern, and the reflected signal is to be collected by a photodetector for further computer processing. The applications for endoscopy are discussed. (C) 1996 Society of Photo-Optical Instrumentation Engineers.
Facile synthesis of core‐surface crosslinked nanoparticles by interblock RAFT polymerization (2010)

Abstract A new, efficient method for synthesizing stable nanoparticles with poly(ethylene oxide) (PEO) functionalities on the core surface, in which the micellization and crosslinking reactions occur in one pot, has been developed. First, amphiphilic PEO‐ b ‐PS copolymers were synthesized by reversible addition fragmentation chain transfer (RAFT) radical polymerization of styrene using (PEO)‐based trithiocarbonate as a macro‐RAFT agent. The low molecular weight PEO‐ b ‐PS copolymer was dissolved in isopropyl alcohol where the block copolymer self‐assembled as core‐shell micelles, and then the core‐shell interface crosslink was performed using divinylbenzene as a crosslinking agent and 2,2′‐azobisisobutyronitrile as an initiator. The design of the amphiphilic RAFT agent is critical for the successful preparation of core‐shell interface crosslinked micellar nanoparticles, because of RAFT functional groups interconnect PEO and polystyrene blocks. The PEO functionality of the nanoparticles surface was confirmed by 1 H NMR and FTIR. The size and morphology of the nanoparticles was confirmed by scanning electron microscopy, transmission electron microscopy, and dynamic laser light scattering analysis. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010