gebhart/patrepeval huggingface dataset:
Proteome rebalancing in soybean seeds can be exploited to enhance foreign protein accumulation (2008)

Seeds possess a high intrinsic capacity for protein production that makes them a desirable bioreactor platform for the manufacture of transgenic products. One strategy to enhance foreign protein production involves exchanging the capacity to produce intrinsic proteins for the capacity to produce a high level of foreign proteins. Suppression of the alpha/alpha' subunit of beta-conglycinin storage protein synthesis in soybean has been shown previously to result in an increase in the accumulation of the glycinin storage protein, some of which is sequestered as proglycinin into de novo endoplasmic reticulum (ER)-derived protein bodies. The exchange of glycinin for conglycinin is quantitative, with the remodelled soybeans possessing a normal protein content with an altered proteome. The green fluorescent protein (GFP)-kdel reporter was transferred in a construct using the glycinin promoter and terminator to mimic glycinin gene expression. When expressed in soybean seeds, GFP-kdel accreted to form ER-derived protein bodies. The introgression of GFP-kdel into the alpha/alpha' subunit of the beta-conglycinin suppression background resulted in a fourfold enhancement of GFP-kdel accumulation to > 7% (w/w) of the total protein in soybean seeds. The resulting seeds accumulated a single population of ER membrane-bound protein bodies that contained both GFP-kdel and glycinin. Thus, the collateral proteome rebalancing that occurs with the suppression of intrinsic proteins in soybean can be exploited to produce an enhanced level of foreign proteins.
Adiponectin Gene Polymorphism and Carotid Artery Intima-Media thickness in Type 2 Diabetes (2005)

The aim of this study was to examine the association between the common polymorphisms of the adiponectin gene (ACDC) and the intima-media thickness (IMT) of the common carotid arteries in type 2 diabetic patients.
Treatment of AIDS-related Kaposi’s Sarcoma With Low-dose Radiotherapy – Follow-up on 2,305 Tumours (2021)

Low-dose radiotherapy is effective for the treatment of many AIDS-related KS patients.
A Collaborative Virtual World Application to the Hyper-Interaction Platform (2007)

We present a hyper-interaction platform which integrates several techniques, including motion tracking, motion recognition, a motion reaction control mechanism, and a high precision 3-D model of the International Space Station. The goal is to build an interaction platform for trainers to navigate in a virtual reality. The platform can be applied to customized mission training. The system integrated visualization environment, underlying 3-D model, and a human body tracking mechanism. The tracking system will be extended to 3-D coordination reconstruction; thus, behaviors of users can be identified on the basis of Back-propagation Neural Networks. These navigation parameters are used in controlling navigation in the 3-D virtual environment which is constructed of VRML. Another important issue of this system is to define a model for motion reaction. The definition of reaction can be applied to avatars or to the virtual environment. These integrated technologies can also be used in other virtual reality environments.
Pl-to-PI: A solution towards secure peer to peer communication network (2017)

File sharing is a corner stone application of network computing. The most popular way to achieve an efficient file sharing through the Internet is to use Peer-to-Peer (P2P) protocols via applications such as BitTorrent. However, BitTorrent is an open file sharing service that allows files to be shared widely without the consent, or control, of the original publisher of the work. Such a fact is undesirable for a lot of organizations and institutions since it raises copyright and content ownership issues. In this paper we propose an efficient BitTorrent-like protocol that aims at privatizing the P2P network such that control over the distribution of copyrighted material can be achieved. This is done by limiting the user set to those authorized based on their machines MAC addresses and by using dedicated equipment, i.e. the Raspberry PI board.
Advances in the Understanding and Treatment of Stroke Impairment Using Robotic Devices (2005)

The presence of robotic devices in rehabilitation centers is now becoming commonplace across the world, challenging heath care professionals to rethink treatment strategies for motor impairment in hemiparetic stroke patients. In this article, we will discuss some of the motivations for using these devices, review clinical outcomes following robotic-assisted training in both the upper and lower extremities, and detail how these devices can provide quantitative evaluations of function. We will also address the clinical issues that need to be considered when using robotic devices to treat stroke patients, and finally a vision of where this field is heading will be discussed.
Molecular Biology of the VEGF and the VEGF Receptor Family (2000)

Vascular endothelial growth factor (VEGF) is the founding member of a still growing family of endothelial cell growth factors. The diverse functions of VEGF and its homologues (PIGF, VEGF-B, VEGF-C, VEGF-D, and VEGF-E) can be explained by their differential binding to the three signaling VEGF receptors. The VEGF family members PIGF and VEGF-B with exclusive binding capacities to the VEGFR-1 can influence monocyte activation and differentiation. The VEGFR-2 and VEGFR-3 binding VEGF homologues, VEGF-C and VEGF-D, are mitogens for both vascular and lymphatic endothelial cells. The orf virus encoded VEGF-E homologue binds and activates only the VEGFR-2 and thus may be the prototype of a vascular endothelial cell-specific growth factor. Further specific activities of VEGF and its homologues result from receptor-specific signaling and differential expression of ligands or receptors. A naturally occurring soluble form of the VEGFR-1 suggests a regulatory role for this receptor. Finally, the production and activation of factors involved in the coagulation/fibrinolytic system provide further evidence for the hypothesis that processes of hemostasis are involved in angiogenesis.
Temperature-dependent Presteady State Kinetics of Lumazine Synthase from the Hyperthermophilic Eubacterium Aquifex aeolicus (2003)

6,7-dimethyl-8-ribityllumazine synthase (lumazine synthase) catalyzes the condensation of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione and 3,4-dihydroxy-2-butanone 4-phosphate. Presteady state kinetic experiments using the enzyme from the hyperthermophilic bacterium Aquifex aeolicus were monitored by multiwavelength photometry. An early optical transient absorbing around 330 nm is interpreted as a Schiff base intermediate obtained by reaction of the position 5 amino group of the heterocyclic substrate with the carbonyl group of 3,4-dihydroxy-2-butanone 4-phosphate. A second transient with an absorption maximum at 445 nm represents an intermediate resulting from the elimination of orthophosphate from the Schiff base. The rate-determining step is the subsequent formation of the 7-exomethylene type anion of 6,7-dimethyl-8-ribityllumazine. The rate constants for the three partial reactions identified by the stopped flow experiments show linear Arrhenius relations in the temperature range of 15-70 degrees C.
Digital twinning of Cellular Capsule Technology: Emerging outcomes from the perspective of porous media mechanics (2021)

Spheroids encapsulated within alginate capsules are emerging as suitable in vitro tools to investigate the impact of mechanical forces on tumor growth since the internal tumor pressure can be retrieved from the deformation of the capsule. Here we focus on the particular case of Cellular Capsule Technology (CCT). We show in this contribution that a modeling approach accounting for the triphasic nature of the spheroid (extracellular matrix, tumor cells and interstitial fluid) offers a new perspective of analysis revealing that the pressure retrieved experimentally cannot be interpreted as a direct picture of the pressure sustained by the tumor cells and, as such, cannot therefore be used to quantify the critical pressure which induces stress-induced phenotype switch in tumor cells. The proposed multiphase reactive poro-mechanical model was cross-validated. Parameter sensitivity analyses on the digital twin revealed that the main parameters determining the encapsulated growth configuration are different from those driving growth in free condition, confirming that radically different phenomena are at play. Results reported in this contribution support the idea that multiphase reactive poro-mechanics is an exceptional theoretical framework to attain an in-depth understanding of CCT experiments, to confirm their hypotheses and to further improve their design.
Model Predictive Control of Integrated Gasification Combined Cycle Power Plants (2010)

The primary project objectives were to understand how the process design of an integrated gasification combined cycle (IGCC) power plant affects the dynamic operability and controllability of the process. Steady-state and dynamic simulation models were developed to predict the process behavior during typical transients that occur in plant operation. Advanced control strategies were developed to improve the ability of the process to follow changes in the power load demand, and to improve performance during transitions between power levels. Another objective of the proposed work was to educate graduate and undergraduate students in the application of process systems and control to coal technology. Educational materials were developed for use in engineering courses to further broaden this exposure to many students. ASPENTECH software was used to perform steady-state and dynamic simulations of an IGCC power plant. Linear systems analysis techniques were used to assess the steady-state and dynamic operability of the power plant under various plant operating conditions. Model predictive control (MPC) strategies were developed to improve the dynamic operation of the power plants. MATLAB and SIMULINK software were used for systems analysis and control system design, and the SIMULINK functionality in ASPEN DYNAMICS was used to test the control strategies on the simulated process. Project funds were used to support a Ph.D. student to receive education and training in coal technology and the application of modeling and simulation techniques.
Cycle-slip detection and repair in integrated navigation systems (2002)

In order to use pure carrier-phase measurements, the initial ambiguities of the measurements have to be solved. Once obtained, these ambiguity solutions can be lost by shadowing, short-time loss of lock on one or several satellites and other effects, commonly referred to as cycle-slips. Restarting the ambiguity resolution algorithm is a time- and computation-intensive task and should be avoided as long as possible. In order to compensate for such short interruptions, an algorithm would be desirable which detects cycle-slips and is able to correct their magnitude for the individual measurements. In this paper an algorithm is presented which detects, using the redundancy inherent in the GPS-measurements, any cycle-slips. The residuals between the Doppler measurement and a calculated Doppler based on a least-squares solution show significant changes whenever cycle-slips occur. Determining in which channel the cycle slip occurred and calculating its size is possible using external information, for instance an INS-system. Instead of using the least-squares solution, the short-term stability of the INS-system is utilized to generate the calculated Doppler. Results are presented for such an integrated system showing the effectiveness in correcting even multiple simultaneous cycle-slips down to the loss of one cycle. The effects of decreasing satellite redundancy on the effectiveness of the algorithm and the influence of the information supplied by the INS system on the quality of the cycle-slip repair are investigated. Since GPS and INS sensors work in a closed loop for correction of the cycle-slips, error detection at this stage is essential for reliable operation of the integrated navigation system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: ACID‐CATALYZED ANGULAR MIGRATION IN A SUBSTITUTED OCTALIN (1974)

Abstract (‐)‐Thujopsen (I) reagiert mit HCl zum Spaltprodukt (II), das über die Grignardverbindung zu (III) reduziert wird.
Through-Walls Communication for Medical Emergency Services (2003)

The authors present a model for bringing the coordination power of workflow management systems to outdoor wearable augmented reality (AR) systems. They portray how mobile equipment may be integrated with adaptive, context-aware work environments. A scenario of a medical emergency task is described to illustrate the functionality of this form of collaboration system. Appropriate information stickers are introduced to support data collection in medical emergency scenarios in a sophisticated form through a hands-free user interface for medical personnel. They propose the use of new user interface technology, including multimedia, AR information stickers, and the allocation of patient medical records to identified locations of the human body. A key feature is the access to relevant information for users in the mobile environment as well as for those in the advanced control room. An additional advantage is the automatic recording of on-site data, which helps to build the medical record of a patient without interfering with the work of the emergency team.
Astrophysical Sources of Cosmic Rays and Related Measurements with the Pierre Auger Observatory (2009)

Submissions to the 31st International Cosmic Ray Conference, Lodz, Poland, July 2009
Reconstruction of FRI Signals using Deep Neural Networks (2019)

Finite Rate of Innovation (FRI) theory considers sampling and reconstruction of classes of non-bandlimited signals, such as streams of Diracs. Widely used FRI reconstruction methods including Prony's method and matrix pencil method involve Singular Value Decomposition (SVD). When samples are corrupted with noise, they achieve an optimal performance given by the Cramer-Rao bound yet break down at a certain Signal-to-Noise Ratio (SNR) due to the so-called subspace swap problem. In this paper, we investigate a deep neural network approach for FRI signal reconstruction that directly learns a transformation from signal samples to FRI parameters. Simulations show significant improvement on the breakdown SNR over existing FRI methods.
Differential sensitivity of normal and transformed human cells to reovirus infection (1978)

Normal and simian virus 40-transformed WI-38 cells exhibited a differential sensitivity to infection with type 3 reovirus. A progressive decrease in viability began 24 to 36 h after infection of transformed cells terminating in complete lysis of cultures by 96 h. Normal cells were productively infected and continued to produce and release virus for as long as 14 days after infection, but exhibited no detectable cytopathology. Inhibition of cellular DNA synthesis began 15 to 18 h after infection in transformed cells before development of cytopathology. No inhibition of DNA synthesis was detected in infected normal cells. No significant differences were noted in the adsorption or early replication characteristics of reovirus in normal and transformed cells. Virus replication and host cell DNA synthesis in normal and transformed human cells were compared to reovirus-infected L-929 mouse fibroblast cells.
26‐1: Invited Paper : Metal Oxide TFT Turnkey Manufacturing Solution for a‐Si TFT Lines (2016)

There is strong incentive to upgrade a‐Si TFT lines with minimal investments to enable high‐end display manufacturing. We developed an oxide TFT manufacturing process which keeps the high‐throughout SiNx GI and wet BCE process used in a‐Si TFT lines, enabling high resolution LCD and OLED display manufacturing with minimal equipment upgrade and production costs.
Depression in the patient with Parkinson's disease. (1990)

Depression is the most commonly encountered mental change in patients with Parkinson's disease. However, its cause is controversial and little is known about its natural history. Some view depression as reactive to the physical disability inherent to Parkinson's disease; however, others view the depressive disorder as the direct result of underlying biochemical changes caused by the disease process. Abnormalities within the serotonin metabolic pathway have been observed in depressed patients with Parkinson's disease and may help to explain why this form of depressive disorder is so common and persistent. Other forms of depression share this biochemical alteration. Attempts to alleviate depression with serotonin agonists have proven successful. Current research efforts are exploring biological aspects of depression in Parkinson's disease and the epidemiology of this disorder as a model of depression in the elderly, medically ill patient.
Surfactant protein-A nanobody-conjugated liposomes loaded with methylprednisolone increase lung-targeting specificity and therapeutic effect for acute lung injury (2017)

The advent of nanomedicine requires novel delivery vehicles to actively target their site of action. Here, we demonstrate the development of lung-targeting drug-loaded liposomes and their efficacy, specificity and safety. Our study focuses on glucocorticoids methylprednisolone (MPS), a commonly used drug to treat lung injuries. The steroidal molecule was loaded into functionalized nano-sterically stabilized unilamellar liposomes (NSSLs). Targeting functionality was performed through conjugation of surfactant protein A (SPANb) nanobodies to form MPS-NSSLs-SPANb. MPS-NSSLs-SPANb exhibited good size distribution, morphology, and encapsulation efficiency. Animal experiments demonstrated the high specificity of MPS-NSSLs-SPANb to the lung. Treatment with MPS-NSSLs-SPANb reduced the levels of TNF-α, IL-8, and TGF-β1 in rat bronchoalveolar lavage fluid and the expression of NK-κB in the lung tissues, thereby alleviating lung injuries and increasing rat survival. The nanobody functionalized nanoparticles demonstrate superior performance to treat lung injury when compared to that of antibody functionalized systems.
Completion energies and scale (2000)

The detection of smooth curves in images and their completion over gaps are two important problems in perceptual grouping. We examine the notion of completion energy of curve elements, showing, and exploiting its intrinsic dependence on length and width scales. We introduce a fast method for computing the most likely completion between two elements, by developing novel analytic approximations and a fast numerical procedure for computing the curve of least energy. We then use our newly developed energies to find the most likely completions in images through a generalized summation of induction fields. This is done through multiscale procedures, i.e., separate processing at different scales with some interscale interactions. Such procedures allow the summation of all induction fields to be done in a total of only O(N log N) operations, where N is the number of pixels in the image. More important, such procedures yield a more realistic dependence of the induction field on the length and width scales: the field of a long element is very different from the sum of the fields of its composing short segments.
Os traços aspectuais condicionantes da alternância causativo-incoativa do português brasileiro (2016)

Esta tese tem o objetivo de descrever e investigar os tracos condicionantes da alternância causativo-incoativa no portugues brasileiro. A investigacao comeca com a hipotese segundo a qual sao os tracos aspectuais dos afixos dos verbos dessas construcoes que fazem emergir tal alternância. Por exemplo, apodrecer: O calor apodreceu a maca resulta na mudanca a maca tornou-se podre. Sob essa condicao, o verbo apodrecer participa tambem da construcao intransitiva a maca apodreceu. Pela mudanca imposta ao argumento interno (ex.: a maca), esse tipo de verbo e, geralmente, denominado verbo de mudanca de estado. De posse dessas informacoes, defendo a hipotese segundo a qual a alternância causativo-incoativa emerge da natureza e da combinacao dos tracos dos verbos de mudanca de estado licenciados em morfemas abstratos e organizados em terminais sintaticos, como preconiza a Morfologia Distribuida (doravante MD). Nesses morfemas sao inseridos os seguintes itens de vocabulario: a raiz e os afixos {a-/en-/es-...-ec-}. Logo, as condicoes para a formacao dos verbos em analise sao: (i) a raiz especificada para dinamicidade; (ii) a projecao de um terminal sintatico, rotulado de ASPP, cujo nucleo contem os tracos [+DINÂMICO, +INCOATIVO], motivados pelos afixos {a-/en-/es-...-ec-}. Os prefixos {a-/en-/es-} realizam o traco [+DINÂMICO], e o sufixo {-ec-} realiza o traco [+INCOATIVO], que projeta o argumento interno com o traco [+MUDANCA DE ESTADO]; (iii) o verbalizador (rotulado de v1) que categoriza o composto formado pela raiz e pelos afixos aspectuais porta o traco [±AGENTE], o qual se conecta com o argumento externo das construcoes em analise; (iv) dessa operacao resulta uma construcao telica. Os dados analisados sao coletados, principalmente, dos seguintes trabalhos: Rio-Torto (2004), Cancado, Godoy e Amaral (2013), Bassani (2013), alem de dicionarios da Lingua Portuguesa. Para o desenvolvimento da analise, adoto os pressupostos da MD combinados com algumas intuicoes da Estrutura de Eventos.
Hormonal regulation of reproductive growth under normal and heat-stress conditions in legume and other model crop species (2016)

Legume crops are grown throughout the world and provide an excellent food source of digestible protein and starch, as well as dietary fibre, vitamins, minerals, and flavonoids. Fruit and seeds from legumes are also an important source of vegetables for a well-balanced diet. A trend in elevated temperature as a result of climate change increases the risk of a heat stress-induced reduction in legume crop yield. High temperatures during the crop reproductive development phase are particularly detrimental to fruit/seed production because the growth and development of the reproductive tissues are sensitive to small changes in temperature. Hormones are signalling molecules that play important roles in a plant's ability to integrate different environmental inputs and modify their developmental processes to optimize growth, survival, and reproduction. This review focuses on the hormonal regulation of reproductive development and heat stress-induced alteration of this regulation during (i) pollination, (ii) early fruit set, and (iii) seed development that affects fruit/seed yield in legume and other model crops. Further understanding of hormone-regulated reproductive growth under non-stress and heat-stress conditions can aid in trait selection and the development of gene modification strategies and cultural practices to improve heat tolerance in legume crops contributing to improved food security.
Tissue characterisation of atherosclerotic plaque in the left main: an in vivo intravascular ultrasound radiofrequency data analysis (2011)

TCFA was present more frequently in the proximal LAD than LMS, supporting the notion that plaque rupture occurs in non-uniform locations throughout the coronary tree and preferentially spares the LMS.