gebhart/patrepeval huggingface dataset:
Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R. (2010)

Curcumin (diferuloylmethane), which has no discernible toxicity, inhibits initiation, promotion and progression of carcinogenesis. 5-Fluorouracil (5-FU) or 5-FU plus oxaliplatin (FOLFOX) remains the backbone of colorectal cancer chemotherapeutics, but produces an incomplete response resulting in survival of cells (chemo-surviving cells) that may lead to cancer recurrence. The present investigation was, therefore, undertaken to examine whether addition of curcumin to FOLFOX is a superior therapeutic strategy for chemo-surviving cells. Forty-eight-hour treatment of colon cancer HCT-116 and HT-29 cells with FOLFOX resulted in 60-70% survival, accompanied by a marked activation of insulin like growth factor-1 receptor (IGF-1R) and minor to moderate increase in epidermal growth factor receptor (EGFR), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (HER-2) as well as v-akt murine thymoma viral oncogene homolog 1 (AKT), cyclooxygenase-2 (COX-2) and cyclin-D1. However, inclusion of curcumin to continued FOLFOX treatment for another 48 h greatly reduced the survival of these cells, accompanied by a concomitant reduction in activation of EGFR, HER-2, IGF-1R and AKT, as well as expression of COX-2 and cyclin-D1. More importantly, EGFR tyrosine kinase inhibitor gefitinib or attenuation of IGF-1R expression by the corresponding si-RNA caused a 30-60% growth inhibition of chemo-surviving HCT-116 cells. However, curcumin alone was found to be more effective than both gefitinib and IGF-1R si-RNA mediated growth inhibition of chemo-surviving HCT-116 cells and addition of FOLFOX to curcumin did not increase the growth inhibitory effect of curcumin. Our data suggest that inclusion of curcumin in conventional chemotherapeutic regimens could be an effective strategy to prevent the emergence of chemoresistant colon cancer cells.
Intramolecular activation of arene carbon-hydrogen bonds by tungsten(II) metal centers and the possible role of metal .pi.-arene intermediates (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular activation of arene carbon-hydrogen bonds by tungsten(II) metal centers and the possible role of metal .pi.-arene intermediatesJudith L. Kerschner, Philip E. Fanwick, Ian P. Rothwell, and John C. HuffmanCite this: Organometallics 1989, 8, 6, 1431–1438Publication Date (Print):June 1, 1989Publication History Published online1 May 2002Published inissue 1 June 1989https://pubs.acs.org/doi/10.1021/om00108a010https://doi.org/10.1021/om00108a010research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Air conditioning system (2023)

An air conditioner comprises a plurality of plates arranged in a successively stacked configuration with portions thereof having a spaced apart arrangement, and defining between successive adjacent pairs of plates at the spaced apart portions a first and second series of discrete alternating passages wherein a first air stream is passed through the first series of passages and a second air stream is passed through the second series of passages; and said stacked configuration of plates forming integrally therewith a liquid delivery means for delivering from a source a sufficient quantity of a liquid to the inside surfaces of the first series of fluid passages in a manner which provides a continuous flow of the liquid from a first end to a second end of the plurality of plates while in contact with the first air stream.
A multi-affine model for tensor decomposition (2011)

Higher-order Singular Value Decomposition (HOSVD) for tensor decomposition is widely used in multi-variate data analysis, and has shown applications in several areas in computer vision in the last decade. Conventional multi-linear assumption in HOSVD is not translation invariant - translation in different tensor modes can yield different decomposition results. The translation is difficult to remove as preprocessing when the tensor data has missing data entries. In this paper we propose a more general multi-affine model by adding appropriate constant terms in the multi-linear model. The multi-affine model can be computed by generalizing the HOSVD algorithm; the model performs better for filling in missing values in data tensor during model training, as well as for reconstructing missing values in new mode vectors during model testing, on both synthetic and real data.
Order from Disorder with Intrinsically Disordered Peptide Amphiphiles (2021)

Amphiphilic molecules and their self-assembled structures have long been the target of extensive research due to their potential applications in fields ranging from materials design to biomedical and cosmetic applications. Increasing demands for functional complexity have been met with challenges in biochemical engineering, driving researchers to innovate in the design of new amphiphiles. An emerging class of molecules, namely, peptide amphiphiles, combines key advantages and circumvents some of the disadvantages of conventional phospholipids and block-copolymers. Herein, we present new peptide amphiphiles comprised of an intrinsically disordered peptide conjugated to two variants of hydrophobic dendritic domains. These molecules termed intrinsically disordered peptide amphiphiles (IDPA), exhibit a sharp pH-induced micellar phase-transition from low-dispersity spheres to extremely elongated worm-like micelles. We present an experimental characterization of the transition and propose a theoretical model to describe the pH-response. We also present the potential of the shape transition to serve as a mechanism for the design of a cargo hold-and-release application. Such amphiphilic systems demonstrate the power of tailoring the interactions between disordered peptides for various stimuli-responsive biomedical applications.
Optimizing the Public Health Benefit of a Medicaid Controlled Substance Lock-In Program (2019)

Medicaid controlled substance lock-in programs (MLIP) have garnered increased attention for their potential role in combating prescription drug abuse. MLIPs are purported to enhance care coordination for high-risk beneficiaries by restricting access to a single prescriber and pharmacy for controlled substance service coverage. However, the MLIP evidence base is largely non-existent. The purpose of this dissertation was to examine two threats to MLIP effectiveness: lock-in circumvention through out-of-pocket purchases and lack of standardized MLIP eligibility criteria. Our aims were to investigate: 1) the effect of enrollment in the North Carolina (NC) MLIP on controlled substance circumvention behavior, 2) prescription-level characteristics of circumvented opioid analgesics, and 3) optimal claims-based measures of high-risk opioid use for assessing MLIP eligibility. We used a retrospective cohort of NC MLIP enrollees and linked NC Medicaid claims and Controlled Substances Reporting System data from 10/1/2009-9/30/2012. Generalized estimating equations estimated the effect of MLIP enrollment and covariates on circumvention behavior (Aim 1). Subjects were 3.6 times more likely to obtain a controlled substance prescription through circumvention after MLIP enrollment. Generalized linear models estimated the association of MLIP enrollment with circumvention of opioids with high-risk prescription-level attributes (Aim 2). Mean prescribed daily opioid dose and the likelihood of a circumvented prescription containing a Schedule II opioid product or a long-acting opioid product did not increase after MLIP enrollment. Medicaid claims data for cross-validation cohorts of opioid users in NC Medicaid were used to test and validate optimal measures of high-risk opioid use (Aim 3). The highest performing dichotomous predictors of overdose were selected using survival receiver operating characteristic models and bivariate Cox model fit. The best measures were ≥5 opioid claims and ≥12 daily milligram morphine equivalents over 60 days, but these exhibited low sensitivity in capturing subjects with overdose. MLIP enrollment induced people to circumvent Medicaid to obtain controlled substance prescriptions, negating the underlying purpose of the MLIP intervention. Also, current MLIP eligibility assessment strategies performed poorly in selecting beneficiaries at highest risk for preventable overdose. Reducing MLIP circumvention and optimizing eligibility criteria to better capture highest risk individuals are necessary to bolster MLIP public health benefit.
High levels of activation-induced cytidine deaminase expression in adult T-cell leukaemia/lymphoma (2011)

Funding sources: This work was supported by Grants‐in‐Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. Conflicts of interest: none declared. Madam, Adult T‐cell leukaemia/lymphoma (ATLL) is a malignancy of mature CD4+ T cells caused by a human T‐cell leukaemia virus type I (HTLV‐1).1 This endemic haematological neoplasm is prevalent in southern Japan and develops in 1–5% of individuals infected with HTLV‐1 after more than two decades of viral persistence. ATLL malignant T cells are usually positive for CD4 and CD25. Cutaneous involvement is seen in up to 50% of patients with ATLL, and various skin eruptions, such as erythroderma, tumours, nodules and papules, are observed. Recently, we showed that the type of skin eruptions is an independent and important prognostic indicator for ATLL.2 Activation‐induced cytidine deaminase (AICDA) is a member of the cytidine deaminase family that acts as an editor of DNA and RNA, and is essential for somatic hypermutation and class‐switch recombination in immunoglobulin genes.3 Several lines of evidence have revealed that inappropriate expression of AICDA acts as a genomic mutator that contributes to tumorigenesis.4 AICDA is highly expressed in malignant cancers, such as gastric cancer and hepatocellular carcinoma, after Helicobacter pylori or hepatitis virus infection.5 In a patient with ATLL, we found that peripheral CD4+ CD25+ cells highly expressed AICDA and contained a mutation of the tumour suppressor gene, TP53. This finding led us to investigate the AICDA expression in peripheral blood and skin‐infiltrating ATLL cells in 18 patients with ATLL.
Intestinal capillary filtration in acute and chronic portal hypertension (1988)

The impact of acute and chronic portal hypertension on the dynamics of intestinal microvascular fluid exchange was examined in anesthetized, fasted, sham-operated control rats with normal portal pressures (CON), during acute elevations in portal pressure (APH) in control rats, and in rats in which chronic portal hypertension (CPH) was produced by calibrated stenosis of the portal vein 10 days prior to the experiments. Although intestinal blood flow and vascular resistance were not altered by APH in control rats, CPH was associated with an increased intestinal blood flow and reduced intestinal vascular resistance when compared with CON and APH. Intestinal capillary pressure and lymph flow were elevated in APH and CPH relative to control values. However, the increase in both variables was greater in CPH. The capillary filtration coefficient was elevated only in CPH. The transcapillary oncotic pressure gradient was not altered by APH or CPH. Interstitial fluid pressure was increased from -1.1 mmHg in CON to 3.9 mmHg during APH and to 5.0 mmHg in CPH. The results of this study indicate that chronic elevations in portal venous pressure produce larger increments in intestinal capillary pressure and filtration rate than do acute elevations in portal venous pressure of the same magnitude. However, the potential edemagenic effects of elevated capillary pressure in both acute and chronic portal hypertension are opposed by increases in lymph flow and interstitial fluid pressure.
“All Labor Has Dignity” — The Case for Wage Equity for Essential Health Care Workers (2021)

“All Labor Has Dignity” Clinicians need look no further than their own institutions to find large groups of employees facing economic and social deprivation. Racial justice in health care cannot be...
Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation (2012)

A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps and second, in gastric cancer, WNT activation confers a poor prognosis. However, the functional significance of deregulated WNT signalling in gastric homoeostasis and cancer is still unclear. In this study we have addressed this by investigating the immediate effects of WNT signalling activation within the stomach epithelium. We have specifically activated the WNT signalling pathway within the mouse adult gastric epithelium via deletion of either glycogen synthase kinase 3 (GSK3) or APC or via expression of a constitutively active β-catenin protein. WNT pathway deregulation dramatically affects stomach homoeostasis at very short latencies. In the corpus, there is rapid loss of parietal cells with fundic gland polyp (FGP) formation and adenomatous change, which are similar to those observed in familial adenomatous polyposis. In the antrum, adenomas occur from 4 days post-WNT activation. Taken together, these data show a pivotal role for WNT signalling in gastric homoeostasis, FGP formation and adenomagenesis. Loss of the parietal cell population and corresponding FGP formation, an early event in gastric carcinogenesis, as well as antral adenoma formation are immediate effects of nuclear β-catenin translocation and WNT target gene expression. Furthermore, our inducible murine model will permit a better understanding of the molecular changes required to drive tumourigenesis in the stomach.
Influence of Framework Silica-to-Alumina Ratio on the Tritiated Water Adsorption and Desorption Characteristics of NaX and NaY Zeolites (2008)

The fixed-bed adsorption process has been studied as one of the promising processes for the recovery of tritiated water in the field of nuclear fusion. The influence of the framework SiO2/Al2O3 ratio ranging from 2.0 to 10.0 on the tritiated water adsorption and desorption characteristics in the H2O-HTO binary systems was systematically examined using NaX and NaY zeolites. A large difference in isotherm was observed by changing the SiO2/Al2O3 ratio from 7.0to 10.0. The framework SiO2-to-Al2O3 ratio has a slight effect on the isotope separation factor. The capacity of removable water from NaY10.0 around room temperature is approximately four times larger than that from NaA2.0 even though both zeolites have nearly the same capacity for absorbable H2O at nearly P=P0= 1:0. The weaker interaction generates the isotope effect on desorption. The HTO dehydration ratio has a strong interrelation with the accumulative amount of purge gas. Dehydration is independent of the flow rate of the purge gas. On the design side of the water adsorption process with multi-absorber systems, the size of the water absorber such as a dryer or dehumidifier can be downscaled with NaY10.0 as the adsorbent since the consideration of the heating and cooling periods necessary for the temperature swing desorption process is not required in the NaY10.0 column.
Self-Assembly of Grid and Helical Hydrogen-Bonded Arrays Incorporating Bowl-Shaped Receptor Sites That Bind Globular Molecules (1999)

Self-assembly of 1,2-dicarbadodecaborane(12) (o-carborane) and bowl-shaped cyclotriveratrylene (CTV) through bifurcated C–Hcarborane⋅⋅⋅O hydrogen bonds gives infinite arrays with 2D hexagonal grid or helical chain topologies. The in-built shape-specific receptor sites bind o-carborane in (o-carborane)2(CTV) or fullerene C70 in (C70)(o-carborane)(CTV)(1,2-dichlorobenzene) shown here.
Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse (2011)

The essential trace mineral selenium is an important determinant of oxidative stress susceptibility, with several studies showing an inverse relationship between selenium intake and cancer. Because different chemical forms of selenium have been reported to have varying bioactivity, there is a need for nutrigenomic studies that can comprehensively assess whether there are divergent effects at the molecular level. We examined the gene expression profiles associated with selenomethionine (SM), sodium selenite (SS), and yeast-derived selenium (YS) in the intestine, gastrocnemius, cerebral cortex, and liver of mice. Weanling mice were fed either a selenium-deficient (SD) diet (<0.01 mg/kg diet) or a diet supplemented with one of three selenium sources (1 mg/kg diet, as either SM, SS or YS) for 100 days. All forms of selenium were equally effective in activating standard measures of selenium status, including tissue selenium levels, expression of genes encoding selenoproteins (Gpx1 and Txnrd2), and increasing GPX1 enzyme activity. However, gene expression profiling revealed that SS and YS were similar (and distinct from SM) in both the expression pattern of individual genes and gene functional categories. Furthermore, only YS significantly reduced the expression of Gadd45b in all four tissues and also reduced GADD45B protein levels in liver. Taken together, these results show that gene expression profiling is a powerful technique capable of elucidating differences in the bioactivity of different forms of selenium.
EMPIRISCHE UNTERSUCHUNG ZUR PERFORMANCE VON ÖFFENTLICHEN WOHNUNGSUNTERNEHMEN (2008)

In Kapitel 4 wird die empirische Untersuchung zur Performance von öffentlichen Wohnungsunternehmen durchgeführt. Zunächst wird das Untersuchungsdesign in Kapitel 4.1 erläutert. Dafür wird die Auswahl der Datenbasis beschrieben und deren Repräsentativität überprüft. Anschließend wird die modellspezifische Vorgehensweise erklärt, bevor die Beschreibung der zu untersuchenden Variablen erfolgt. Es schließen sich die (univariaten und multivariaten) empirischen Analysen in Kapitel 4.2 an, deren Ergebnisse in Kapitel 4.3 noch einmal zusammengefasst werden.
Regional networks underlying interhemispheric connectivity: An EEG and DTI study in healthy ageing and amnestic mild cognitive impairment (2008)

Interhemispheric coherence derived from electroencephalogram (EEG) recordings is a measure of functional interhemispheric connectivity. Diffusion tensor imaging (DTI) determines the integrity of subcortical fiber tracts. We studied the pattern of subcortical fiber tracts underlying interhemispheric coherence and its alteration in 16 subjects with amnestic mild cognitive impairment (MCI), an at risk syndrome for Alzheimer's disease, and 20 cognitively healthy elderly control subjects using resting state EEG and high resolution DTI at 3 T. We used a multivariate network approach based on principal component analysis to determine effects of coherence on the regional pattern of diffusivity. Temporo-parietal coherence in the alpha band was significantly correlated with diffusivity in predominantly posterior white matter tracts including posterior corpus callosum, parietal, temporal and occipital lobe white matter, thalamus, midbrain, pons, and cerebellum, both in MCI subjects and controls (P < 0.05). In MCI subjects, frontal coherence in the alpha band was significantly correlated with a predominately frontal pattern of diffusivity including fiber tracts of the anterior corpus callosum, frontal lobe white matter, thalamus, pons, and cerebellum (P < 0.05). The study provides a methodology to access specific networks of subcortical fiber tracts subserving the maintenance of interhemispheric resting state coherence in the human brain.
Sweat Rates And Sweat Electrolyte Concentrations In Heat-acclimatized Youth Soccer Players (2005)

Soccer is an increasingly popular sport with youth. During practices and games in the heat, young athletes can lose significant amounts of sweat and electrolytes. Although normal ranges for sweat sodium and potassium have been established for adult athletes, little data exist on the sweat electrolyte composition of young athletes. Purpose To measure sweat rate and sweat [Na+] and [K+] in age-group soccer players. Methods 28 youth soccer players (17 females; 11 males) from a southwest soccer club in the US volunteered to participate. Players were in the following age groups: 10y (95s; n = 11), 13 y (92; n = 8), and 17 y (88s; n = 9). All subjects provided a pre-practice urine sample to assess their hydration status via urine specific gravity (USG). Body weight measurements were taken before and after practice in either dry shorts (males) or bathing suits (females). Participants were provided with beverage bottles that were weighed before and after practice to determine fluid intake during practice. After a standard 20-min warm-up was completed sweat patches were placed on the forehead, scapula, chest, forearm, and thigh. Patches were analyzed for [Na+] and [K+] concentrations. Data presented here are from the scapula patch and were collapsed among gender (MSSE 24:76, 92). Sweat losses were calculated from change in body weight corrected for fluid intake. Results The adjacent table presents the mean values with standard deviations:TableConclusion Consistent with the literature from lab-based studies, sweat rate increased with age of the soccer players. Sweat sodium concentrations appeared to be lowest in the youngest age group.
An improved algorithm for k-nearest-neighbor finding and surface normals estimation (2009)

This paper is to improve the speed of k-nearest-neighbor search and put forward algorithms related to tangent plane estimation based on existing methods. Starting from the points cloud, the algorithm segments the whole data into many different small cubes in space, and the size of cube is related to the density of the points cloud. Considering the position of the point in the cube, the algorithm enlarges the area around the given point step by step until the k-nearest-neighbor is accomplished. The neighbor's least-squares tangent plane is estimated. In order to orient the planes, the k-nearest-neighbor is introduced into the problem of seeking the minimum spanning trees instead of searching the whole data. The research proved that the algorithms put forward in this paper were effective in processing data in short time and with high precision. The theory was useful for the practical application in reverse engineering and other areas related. Solution for finding k-nearest-neighbor problem, which still costs much time in present, was provided, and a propagation algorithm for orienting the planes was also discussed. The algorithm chose the orientation among the k-nearest-neighbor of the current point.