gebhart/patrepeval huggingface dataset:
Quasi-smooth control of chained systems (1999)

The problem of exponential stabilization for high-order chained systems with two control inputs is addressed and solved using a particular class of discontinuous dynamic state feedback control laws. The proposed method substantially improves the existing results in several respects. Firstly no limitation on the plant initial conditions needs to be imposed; secondly the method can be used to stabilize a much larger class of nonlinear systems which cannot be exponentially stabilized by smooth control; finally, although Lyapunov stability cannot be ensured, the closed loop controlled system possesses a weak Lyapunov stability property.
Maximizing Aggregate Throughput in 802.11 Mesh Networks with Physical Carrier Sensing and Two-Radio Multi-Channel Clustering (2006)

Spatial reuse in a mesh network allows multiple communications to proceed simultaneously, hence proportionally improving the overall network throughput. To maximize spatial reuse, the MAC protocol must enable simultaneous co-channel transmitters to maintain a separation distance that is sufficient to avoid interference. Within that distance, a set of orthogonal channels is employed by different links. This paper demonstrates that physical carrier sensing enhanced with a tunable sensing threshold is effective at avoiding co-channel interference in 802.11 mesh (static + multi-hop) networks. Moreover, for multi-channel mesh networks, an architecture for channel clustering based on two-radio nodes is proposed. Distributed clustering is achieved using the Highest-Connectivity Cluster (HCC) algorithm. All inter-cluster communications are performed on a common channel using the default radio, while intra-cluster communications use the secondary radio with channel selection based on a new Minimum Interference Channel Selection (MIX) algorithm that minimizes the co-channel interference (CCI). Backward compatibility is guaranteed by allowing legacy single-channel devices to connect to the new two-radio devices through the common default radio. Simulation results for large-scale 802.11b and 802.11a networks demonstrate the significant improvement in one-hop aggregate throughput. Specifically, the new two-radio multi-channel mesh solution increases the aggregate through-put by more than twice w.r.t. the traditional single-radio single-channel mesh.
Challenges in Securing Vehicular Networks (2005)

In the near future, most new vehicles will be equipped with shortrange radios capable of communicating with other vehicles or with highway infrastructure at distances of at least one kilometer. The radios will allow new applications that will revolutionize the driving experience, providing everything from instant, localized traffic updates to warning signals when the car ahead abruptly brakes. While resembling traditional sensor and ad hoc networks in some respects, vehicular networks pose a number of unique challenges. For example, the information conveyed over a vehicular network may affect life-or-death decisions, making fail-safe security a necessity. However, providing strong security in vehicular networks raises important privacy concerns that must also be considered. To address these challenges, we propose a set of security primitives that can be used as the building blocks of secure applications. The deployment of vehicular networks is rapidly approaching, and their success and safety will depend on viable security solutions acceptable to consumers, manufacturers and governments.
Prevention of postoperative microbial infection by synbiotics. (2008)

Prevention of infectious complications after major surgeries including those for cancer has been a major concern in the clinical field. To overcome this problem, probiotics and synbiotics (combination of probiotics and prebiotics have recently been introduced for post-operative treatment. Clinical application of synbiotics in severe cases, such as severe pediatric surgical cases, acute pancreatitis, liver transplantation, and biliary cancer, has been reported. The present article deals with the clinical effect of such synbiotic therapies for the patients under emergency medical care, and discusses the possible mechanism of action and prospect of synbiotic therapy.
Double C−H Activation Strategy for the Asymmetric Synthesis of C2-Symmetric Anilines (2004)

Rh(2)(S-DOSP)(4)-catalyzed C-H activation to N,N-dimethylanilines is described. A double C-H activation was possible by using an excess of methyl aryldiazoacetate, and this provided a very direct approach to C(2)-symmetric anilines. [reaction--see text]
Microbial Degradation of the Multiply Branched Alkane 2,6,10,15,19,23-Hexamethyltetracosane (Squalane) by Mycobacterium fortuitum and Mycobacterium ratisbonense (2000)

Among several bacterial species belonging to the general Gordonia, Mycobacterium, Micromonospora, Pseudomonas, and Rhodococcus, only two mycobacterial isolates, Mycobacterium fortuitum strain NF4 and the new isolate Mycobacterium ratisbonense strain SD4, which was isolated from a sewage treatment plant, were capable of utilizing the multiply branched hydrocarbon squalane (2,6,10,15,19, 23-hexamethyltetracosane) and its analogous unsaturated hydrocarbon squalene as the sole carbon source for growth. Detailed degradation studies and high-pressure liquid chromatography analysis showed a clear decrease of the concentrations of squalane and squalene during biomass increase. These results were supported by resting-cell experiments using strain SD4 and squalane or squalene as the substrate. The degradation of acyclic isoprenoids and alkanes as well as of acids derived from these compounds was also investigated. Inhibition of squalane and squalene degradation by acrylic acid indicated the possible involvement of beta-oxidation in the degradation route. To our knowledge, this is the first report demonstrating the biodegradation of squalane by using defined axenic cultures.
Intensity and Mechanisms of Fluoroquinolone Resistance within the H 30 and H 30Rx Subclones of Escherichia coli Sequence Type 131 Compared with Other Fluoroquinolone-Resistant E. coli (2015)

The recent expansion of the H30 subclone of Escherichia coli sequence type 131 (ST131) and its CTX-M-15-associated H30Rx subset remains unexplained. Although ST131 H30 typically exhibits fluoroquinolone resistance, so do multiple other E. coli lineages that have not expanded similarly. To determine whether H30 isolates have more intense fluoroquinolone resistance than other fluoroquinolone-resistant E. coli isolates and to identify possible mechanisms, we determined the MICs for four fluoroquinolones (ciprofloxacin, levofloxacin, moxifloxacin, and norfloxacin) among 89 well-characterized, genetically diverse fluoroquinolone-resistant E. coli isolates (48 non-H30 and 41 H30 [23 H30Rx and 18 H30 non-Rx]). We compared the MICs with the H30 and H30Rx status, the presence/number of nonsynonymous mutations in gyrA, parC, and parE, the presence of aac(6')-1b-cr (an aminoglycoside/fluoroquinolone agent-modifying enzyme), and the efflux pump activity (measured as organic solvent tolerance [OST]). Among 1,518 recent E. coli clinical isolates, ST131 H30 predominated clonally, both overall and among the fluoroquinolone-resistant isolates. Among the 89 study isolates, compared with non-H30 isolates, H30 isolates exhibited categorically higher MICs for all four fluoroquinolone agents, higher absolute ciprofloxacin and norfloxacin MICs, more nonsynonymous mutations in gyrA, parC, and parE (specifically gyrA D87N, parC E84V, and parE I529L), and a numerically higher prevalence of (H30Rx-associated) aac(6')-1b-cr but lower OST scores. All putative resistance mechanisms were significantly associated with the MICs [for aac(6')-1b-cr: ciprofloxacin and norfloxacin only]. parC D87N corresponded with ST131 H30 and parE I529L with ST131 generally. Thus, more intense fluoroquinolone resistance may provide ST131 H30, especially H30Rx [if aac(6')-1b-cr positive], with subtle fitness advantages over other fluoroquinolone-resistant E. coli strains. This urges both parsimonious fluoroquinolone use and a search for other fitness-enhancing traits within ST131 H30.
A Conformationally Constrained Peptidomimetic Binds to the Extracellular Region of HER2 Protein (2010)

Human epidermal growth factor receptor 2 (HER2) is a member of the human epidermal growth factor receptor kinases (other members include EGFR or HER1, HER3, and HER4) that are involved in signaling cascades for cell growth and differentiation. It is well established that HER2-mediated heterodimerization has important implications in cancer. Deregulation of signaling pathways and overexpression of HER2 is known to occur in cancer cells, indicating a role of HER2 in tumorigenesis. Therefore, blocking HER2-mediated signaling has potential therapeutic value. We have designed several peptidomimetics to inhibit HER2-mediated signaling for cell growth. One of the compounds (HERP5, Arg-beta Naph-Phe) exhibited antiproliferative activity with IC(50) values in the micromolar-to-nanomolar range in breast cancer cell lines. Binding of fluorescently labeled HERP5 to HER2 protein was evaluated by fluorescence assay, microscopy, and circular dichroism spectroscopy. Results indicated that HERP5 binds to the extracellular region of the HER2 protein. Structure of the peptidomimetic HERP5 was studied by NMR and molecular dynamics simulations. Based on these results a model was proposed for HER2-EGFR dimerization and possible blocking by HERP5 peptidomimetic using a protein-protein docking method.
Hollow infrared fiber with an inorganic inner coating layer with high durability (2007)

A coating material characterized by wide-range thermal stability, water repellence, and physiological inertness. is newly employed as a dielectric layer in the dielectric-coated silver hollow optical fiber. This material, whose trade name is OC-300, is a semi-inorganic polymer based on the structural unit R<sub>2</sub>SiO, where R is an organic group. A smooth hardened film is formed at room-temperature on the silver layer by using a liquid-phase coating technique. The transmission properties of the OC-300 coated silver hollow fiber are evaluated for infrared laser light. Sterilization experiments by using an autoclave shows that the hollow fiber showed strong durability and promising application in medical filed as well as in other harsh environment.
[Principal cellular and molecular mechanisms of xenobiotic-induced hypersensitivity reactions]. (1999)

Sensitization to xenobiotic first involves an interaction between the compound and antigen presenting cells such as Langerhans cells within the epidermis. This leads to the transdermal migration of this presenting cells towards draining lymph nodes. A second step consists in activation, proliferation and differenciation of CD4+ T cells, and CD8+ T lymphocytes involved in delayed hypersensitivity reactions such as contact dermatitis. T helper lymphocytes can differenciate into Th1 (producing interferon-gamma and interleukin (IL)-2) or Th2 (producing IL-4, IL-5, IL-10, IL-13) lymphocytes. Some experimental models allowed to demonstrate a link between Th1- or Th2-type responses and different hypersensitivity reactions. Specific antibody production also plays a key role in xenobiotic-induced allergy, especially IgE production involved in mastocytes degranulation and immediate hypersensitivity reactions.
In vivo administration of major histocompatibility complex class I‐specific peptides from influenza virus induces specific cytotoxic T cell hyporesponsiveness (1993)

We have been investigating the immunogenicity of two class I major histocompatibility complex-specific peptides with a sequence derived from influenza virus nucleoprotein specific for Kd and one for Db. Peptide-modified splenocytes are unable to immunize for a primary cytotoxic T (Tc) cell response in vivo, or secondary response in vitro. Peptide-modified stimulator cells can boost virus-primed splenocytes for a strong secondary response in vitro. Animals primed with syngeneic peptide-modified splenocytes upon challenge with virus in vivo do not generate strong secondary Tc cell responses on day 3 after challenge in contrast to virus primed animals. Day 6 responses of virus-challenged, peptide-primed animals are reduced as compared to unprimed mice. This hyporesponsiveness is independent of CD8+ T cells in the priming population and can be elicited with tumor cell lines. The data are discussed in the framework of the two-signal model of immune induction.
Zařízení pro plazmové opracování semen za atmosférického tlaku (2013)

Zařizeni pro plazmove opracovani semen založene na
dielektrickem koplanarnim povrchovem barierovem výboji DCSBD,
který pracuje za atmosferickeho tlaku. Pracovni frekvence je 15
kHz. Byl vyřesen problem s posuvem osiva po plose výboje.
Funkcni vzorek byl vyroben na zakladě ověřeni vlastnosti
koplanarniho výboje výboje pro opracovani osiva.
Strukturierung und Metallisierung (2013)

No AccessRäumliche elektronische Baugruppen (3D-MID)May 2013Strukturierung und MetallisierungR. SchrammR. SchrammSearch for more papers by this authorhttps://doi.org/10.3139/9783446437784.003SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2013Pages: 65-116Print ISBN: 978-3-446-43441-7eISBN: 978-3-446-43778-4 Copyright & Permissions© 2013 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Air Pollution from Road Traffic and Systemic Inflammation in Adults: A Cross-Sectional Analysis in the European ESCAPE Project (2015)

Living close to busy traffic was associated with increased CRP concentrations, a known risk factor for cardiovascular diseases. However, it remains unclear which specific air pollutants are responsible for the association.
Influence of Age on Immune Changes in Runners after a Marathon (2002)

Immune changes in 75 younger (age 37.4 ± 0.9 years) and 23 older (57.0 ± 1.4 years) runners were compared after a competitive marathon, with blood samples collected pre- and immediately and 1.5 hr postrace. Race times were slower for the older group (4.7 ± 0.2 vs. 4.3 ± 0.1 hr, p = .015), but both groups performed at similar intensity (83.4 ± 0.9 vs. 82.9 ± 0.5% HR max ). The pattern of change in plasma cortisol, epinephrine, growth hormone, and blood leukocyte subsets did not differ significantly between the groups postrace. Blood lymphocyte counts were 20–24% lower in the older runners at each time point because of reduced T-cell counts. Postrace, plasma levels of IL-1ra, -10, -6, and -8 rose strongly in all runners, and salivary IgA secretion rate decreased, but no group differences in the pattern of change were noted. In conclusion, younger and older runners experienced similar hormonal and immune changes after running a marathon.
Kinetics of the formation of equilibrium relief during the running-in of steel 45–steel 65G friction pair (2015)

The running-in of a wear-resistant steel 45–steel 65G friction pair is accompanied by cyclic changes in the asperity heights, followed by a gradual decrease in the amplitudes of these changes to the equilibrium values. Changes in the microgeometry of the surfaces of the pair have opposite patterns and are accompanied by periodical variations in the microhardness of the softer material. The primary mechanisms that govern this wear mode are the processes of plastic deformation and strain hardening of the surfaces, as well as their fatigue and adhesive fracture, which also occur cyclically during an equilibrium relief of the friction surfaces is formed.
La relazione tra ruolo imprenditoriale e piccole aziende ad alto potenziale: una proposta di inquadramento concettuale (2007)

This paper is addressed to discuss about the subjective characteristics of entrepreneurs that allow them to start or to run small firms able to contribute in a stable and relevant manner to the local development (high-potential firms). For this purpose a literature analysis and a field research based on a sample of 101 small firms have been conducted. This topic is discussed with reference to a backward area context which is also characterized by the presence of many policy measures aimed to directly support small business. Some policy measures indication emerge, that address the necessity to propose innovative instruments aimed to reinforce and to support, in a business management perspective, the entrepreneurial role in order to sustain the economic development.
Compact Semiconductor Lasers (2014)

This book brings together in a single volume a unique contribution by the top experts around the world in the field of compact semiconductor lasers to provide a comprehensive description and analysis of the current status as well as future directions in the field of micro- and nano-scale semiconductor lasers. It is organized according to the various forms of micro- or nano-laser cavity configurations with each chapter discussing key technical issues, including semiconductor carrier recombination processes and optical gain dynamics, photonic confinement behavior and output coupling mechanisms, carrier transport considerations relevant to the injection process, and emission mode control. Required reading for those working in and researching the area of semiconductors lasers and micro-electronics.
Belzoni's mummy' (1923)

Belzoni's mummy' Get access G. A. R. Fitzgerald G. A. R. Fitzgerald Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s12-XII, Issue 252, 10 February 1923, Page 111, https://doi.org/10.1093/nq/s12-XII.252.111b Published: 10 February 1923
Polypill Therapy for Recalcitrant Clinically Significant Macular Edema: A Prospective Case Series (2019)

Abstract:Background: To determine the utility of the polycap in treatment of refractory diabetic macular edema.Methods: Prospective case series. The study included 60 patients (>18 years; 37 males) with well controlled type2 diabetes mellitus, hypertension and dyslipidemia and diffuse CSME (clinically significant macular edema)refractory to conventional therapy. Patients included had received at least 1). Three intravitreal ranibizumabinjections and two sessions of macular laser photocoagulation. A complete ocular and systemic exam wasperformed along with FFA (fluorescein angiography) and OCT (Optical Coherence Tomography). The polypill wasadministered orally once daily in the morning after breakfast. Monthly follow-ups were scheduled. Appropriatestatistical analysis was done. Outcome measures: Primary-the change in VA from baseline over one year.Secondary-The change in CMT over one year and adverse events.Results: The median age was 60.4 ± 5.42. Median duration of diabetes: 13.24 ± 4.18 years. 21 patients were onboth oral hypoglycemic and insulin therapy. The median duration of CSME was 11.65 ± 3.47 months (5-26 months).Baseline VA improved from 0.72 ± 0.16 logMAR to 0.64 ± 0.09 logMAR (p=0.03) at one year. Median CMT improvedfrom 364.2 ± 31 microns to 297.23 ± 30.11 at one year (p=0.027). Systemic parameters too improved significantly.No adverse events were noted.Conclusion: The polypill appeared safe and effective in treatment of recalcitrant diabetic macular edema,probably by improved compliance. Trial Registration: N/A.
The autoradiographic localization of intracellular antibody. (1959)

A method developed for localizing antibody in imprints of lymphoid organs of immunized animals involves treating the fixed imprints with radio-iodinated homologous antigen, washing to remove uncombined antigen and then making an autoradiograph. Finally the imprints are stained with the autoradiographic film in situ. A number of artefacts interfere with this procedure, and steps have been taken to overcome them. Antibody is localized by this method in plasma cells. The number of grains over an individual cell is proportional to the amount of radioactive material it has fixed, so that the method is potentially capable of yielding quantitative results.
Utviklingstrekk på rusmiddelfeltet : Grunnlagsmateriale til regjeringens stortingsmelding om rusmiddelpolitikken (2011)

Underlagsmateriale til ny stortingsmelding\n\nI forbindelse med den kommende stortingsmeldingen om rusmiddelpolitikken, fikk SIRUS i oppdrag fra Helse- og omsorgsdepartementet å bidra med en oppsummering og analyse av nasjonale og internasjonale utviklingstrekk på rusmiddelfeltet. Grunnlagsmaterialet som er oversendt departementet er samlet i SIRUS-rapport nr 3/2011: Utviklingstrekk på rusmiddelfeltet - Grunnlagsmateriale til regjeringens stortingsmelding om rusmiddelpolitikken.\nBred dekning av problemstillinger\n\nRapporten består av tre deler. Del 1 omhandler ulike problemstillinger som gjelder så vel alkohol som narkotika. Eksempelvis gis det gjennomgang av utviklingen når det gjelder tjenestetilbudet til rusmiddelmisbrukere. Videre drøftes begrepsbruken på rusmiddelfeltet, hva som er avhengighet, ulike sider ved skadereduksjon, ulike skader og problemer ved rusmiddelbruk, hva som gjøres når det gjelder barn som pårørende av rusmiddelmisbrukere og kartleggingsverktøy for rusmiddelmisbrukere i behandling. Det gis også en drøfting av utfordringene knyttet til økte krav om at behandling for rusmiddelmisbruk skal være evidensbasert og problemene med å beregne samfunnsøkonomiske kostnader av rusmiddelbruk. \nAlkohol- og narkotikapolitikk\n\nDel 2 omhandler alkoholpolitikk og utvikling i konsum og alkoholrelaterte skader. Når det gjelder alkoholpolitikk, gis det en kort gjennomgang av utviklingen i norsk og internasjonal alkoholpolitikk og virkemidlene i den statlige og kommunale styringen av den norske alkoholpolitikken. Det gis videre en oversikt over utviklingen i alkoholforbruket i Norge og alkoholrelaterte skader og problemer.\n\nDel 3 ser på utviklingen når det gjelder bruk og misbruk av narkotika og narkotikarelaterte skader. Videre gis det en drøfting av narkotikasituasjonen i Norge sett i et europeisk perspektiv og det stilles spørsmål om hvorvidt Norge beveger seg i retning av en mindre restriktiv narkotikapolitikk enn hva som var tilfeller på 1990-tallet. Det gis også en oversikt over utviklingen når det gjelder bruk av vanedannende legemidler.