gebhart/patrepeval huggingface dataset:
Wild bees and their nests host Paenibacillus bacteria with functional potential of avail (2018)

The isolated wild bee associate Paenibacillus MBD-MB06 is a common, but irregularly occurring part of wild bee microbiomes, present on adult body surfaces and guts and within nests especially in megachilids. It was phylogenetically and functionally distinct from harmful members causing honey bee colony diseases, although it shared few conserved proteins putatively toxic to insects that might indicate ancestral predisposition for the evolution of insect pathogens within the group. By contrast, our strain showed anti-microbial capabilities and the genome further indicates abilities for chitin-binding and biofilm-forming, suggesting it is likely a useful associate to avoid fungal penetration of the bee cuticula and a beneficial inhabitant of nests to repress fungal threats in humid and nutrient-rich environments of wild bee nests.
[Carnosine and anserine as specialized pH-buffers--hydrogen ion carriers]. (1992)

Data are reviewed that carnosine (pK 6.9) and anserine (pK 7.1) act as specific mobile pH buffers promoting a rapid elimination of pH gradients between different parts of muscle fibers (very large cells containing various structural components, such as actomyosin, Z-discs, mitochondrial and sarcoplasmic reticulum, etc.). The specific role of these muscle dipeptides as pH buffers (H(+)-translocators) provides explanation for the so-called "Severin phenomenon"-a manyfold enhancement by carnosine of the ability of the isolated muscle to contract and accumulate lactate.
Long non-coding RNA SPRY4-IT1 promotes proliferation and invasion by acting as a ceRNA of miR-101-3p in colorectal cancer cells (2017)

Long non-coding RNAs are associated with a spectrum of biological processes such as gene regulation on transcriptional and post-transcriptional levels. Increasing evidence indicates that SPRY4-IT1 plays an important role in carcinogenesis, and the mechanisms whereby SPRY4-IT1 induces colorectal carcinoma progression remain largely unknown. The aim of this study is to evaluate the expression and function of SPRY4-IT1 in colorectal carcinoma. In this study, we analyzed SPRY4-IT1 expression levels in a series of colorectal carcinoma patients by quantitative reverse transcription polymerase chain reaction. Knockdown of SPRY4-IT1 by RNA interference was performed to explore its roles in cell proliferation, migration, and invasion. Our results found that SPRY4-IT1 was upregulated in human primary colorectal carcinoma tissues. Knockdown of SPRY4-IT1 inhibited colorectal carcinoma cell proliferation, migration, and invasion. Moreover, we confirmed that the expression of epithelial-mesenchymal transition-related genes was modulated through alteration of SPRY4-IT1 expression. SPRY4-IT1 could negatively regulate the expression of miR-101-3p in colorectal carcinoma cells. The bioinformatics prediction revealed putative miR-101-3p binding sites within SPRY4-IT1 transcripts. Above all, knockdown of SPRY4-IT1 could represent a rational therapeutic strategy for colorectal carcinoma.
S-Endoglin Expression Is Induced in Senescent Endothelial Cells and Contributes to Vascular Pathology (2008)

Senescence of endothelial cells (ECs) may contribute to age-associated cardiovascular diseases, including atherosclerosis and hypertension. The functional and gene expression changes associated with cellular senescence are poorly understood. Here, we have analyzed the expression, during EC senescence, of 2 different isoforms (L, long; S, short) of endoglin, an auxiliary transforming growth factor (TGF)-β receptor involved in vascular remodeling and angiogenesis. As evidenced by RT-PCR, the S/L ratio of endoglin isoforms was increased during senescence of human ECs in vitro, as well as during aging of mice in vascularized tissues. Next, the effect of S-endoglin protein on the TGF-β receptor complex was studied. As revealed by coimmunoprecipitation assays, S-endoglin was able to interact with both TGF-β type I receptors, ALK5 and ALK1, although the interaction with ALK5 was stronger than with ALK1. S-endoglin conferred a lower proliferation rate to ECs and behaved differently from L-endoglin in relation to TGF-β–responsive reporters with ALK1 or ALK5 specificities, mimicking the behavior of the endothelial senescence markers Id1 and plasminogen activator inhibitor-1. In situ hybridization studies demonstrated the expression of S-endoglin in the endothelium from human arteries. Transgenic mice overexpressing S-endoglin in ECs showed hypertension, decreased hypertensive response to NO inhibition, decreased vasodilatory response to TGF-β 1 administration, and decreased endothelial nitric oxide synthase expression in lungs and kidneys, supporting the involvement of S-endoglin in the NO-dependent vascular homeostasis. Taken together, these results suggest that S-endoglin is induced during endothelial senescence and may contribute to age-dependent vascular pathology.
Rapid Proliferation of Sublines of NCTC Clone 929 (Strain L) Mouse Cells in a Simple Chemically Defined Medium (MB 752/1)2 (1959)

Journal Article Rapid Proliferation of Sublines of NCTC Clone 929 (Strain L) Mouse Cells in a Simple Chemically Defined Medium (MB 752/1) Get access Charity Waymouth Charity Waymouth Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 22, Issue 5, May 1959, Pages 1003–1017, https://doi.org/10.1093/jnci/22.5.1003 Published: 01 May 1959 Article history Received: 09 January 1959 Published: 01 May 1959
Hydrogen sulphide protects mouse pancreatic β‐cells from cell death induced by oxidative stress, but not by endoplasmic reticulum stress (2010)

H₂S may prevent pancreatic β-cells from cell apoptosis via an anti-oxidative mechanism and the activation of Akt signalling.
Joint Optimal Multipath Routing and Rate Control for Multidescription Coded Video Streaming in Ad Hoc Networks (2008)

This paper studies an important problem, namely, the joint multipath routing and rate control for multidescription coded (MD-coded) video streaming in wireless ad hoc networks. In addition to selecting a pair of paths to optimize the expected end-to-end video quality, we also explore an optimal packet skipping strategy for the rate control in order to minimize the impact of the skipped packets on the quality of the video. The R-D hint information, consisting of the size of the packets in bits and the importance of the packets for reconstructing the video, is used to characterize the packets in an R-D sense. Since searching for paths to minimize the expected end-to-end video distortion by simultaneously considering the skipped packets prior to the transmission and those dropped/delayed during the transmission is a highly complex problem and is expected to be NP-hard, we develop a heuristic greedy-relaxation-based routing solution that enables the system to efficiently select near-optimal paths. Extensive simulation studies have been conducted to compare the performance of the proposed algorithm with that of several existing algorithms, showing the superior performance of the proposed one. Such a joint rate control and multipath routing approach provides an important methodology for high-quality real-time video streaming applications over ad hoc wireless networks.
The mass spectrometric fragmentation patterns of some biologically active 1,3,4‐thiadiazoles (1977)

Abstract Mass spectra of some twelve derivatives of 1,3,4‐thiadiazole are reported. The fragmentation scheme of the 1,3,4‐thiadiazole ring is specific and indicative as to the structure. Derivatives of 5‐phenyl‐1,3,4‐thiadiazoles show rearrangement to isothiocyanates.
4289Clinical outcomes of percutaneous mitral valve repair in secondary mitral regurgitation: a systematic review and meta-analysis (2019)

Abstract Background The benefit of percutaneous mitral valve repair with mitraclip (PMVR) in patients with secondary mitral regurgitation (MR) is still debated. Methods In order to compare the outcome of PMVR with optimal medical therapy (OMT) versus OMT alone in patients with secondary MR, we performed a systematic review and meta-analysis of 2 randomized clinical trials (RCT) and 7 non-randomized observational studies (nROS). Hazard ratios (HR) and 95% confidence intervals (CI) were pooled through inverse variance random-effect model to compute the summary effect size for all-cause mortality, cardiovascular death and cardiac-related hospitalization. Subgroup and meta-regression analysis were also performed. Results An overall population of 3,118 individuals (67% men; mean age, 73 years) was included: 1,775 PMVR+OMT and 1,343 OMT patients, with mean follow-up of 24±15 months. PMVR+OMT was associated with a lower risk of all-cause death (HR: 0.77; 95% CI: 0.68–0.87), cardiovascular death (HR: 0.55; 95% CI: 0.34–0.89) and cardiac-related hospitalization (HR: 0.77; 95% CI: 0.64–0.92). Meta-regression analysis showed that larger left ventricular end-diastolic volume index (LVEDVI) portends higher mortality after PMVR (p&lt;0.001). Conclusions This study-level meta-analysis shows that PMVR+OMT is associated with reduced all-cause death, cardiovascular death and cardiac-related hospitalization when compared with OMT alone in secondary MR. LVEDVI is a predictive marker of efficacy, as patients with smaller LVEDVI derive the largest benefit from PMVR.
Performance evaluation of COFDM for digital audio broadcasting. I. Parametric study (1997)

This paper describes the performance of COFDM (coded orthogonal frequency division multiplexing) for digital audio broadcasting (DAB) over various multipath mobile radio channels. COFDM is a channel coding and modulation scheme which mitigates the adverse effects of fading by using wideband multicarrier modulation combined with time interleaving and a convolutional error correcting code. A guard interval is inserted at the transition between successive symbols to absorb the intersymbol interference created by the time domain spread of the mobile radio channel. The decoding process is performed using differential demodulation in conjunction with a soft decision Viterbi decoder. The COFDM evaluation is done by means of computer simulations. A parametric study of the proposed COFDM system is done in this first of a series of papers to determine the optimal system parameter values for operation at a radio frequency of 1.5 GHz. The results show that the parameter values proposed in the standard are indeed well suited for operation at 1.5 GHz. Using the set of optimal parameter values found, the COFDM performance is then evaluated in mobile radio channels typical of different geographical environments. Simulation results confirm the benefit that the system gains from frequency diversity found in the urban and hilly terrain areas.
Les nouveaux systèmes d’assistance mécanique de la circulation (2004)

Auteur(s) : Daniel Loisance Service de chirurgie thoracique et cardiovasculaire, CNRS UMR 7054 – association Claude Bernard, hopital Henri Mondor, 51, avenue du Marechal de Lattre de Tassigny, 94010 Creteil cedex, France Depuis le debut des annees 1980, les techniques d’assistance mecanique de la circulation sont progressivement entrees dans la pratique clinique, et ce, essentiellement dans l’objectif de l’attente de la transplantation ou de la recuperation d’une fonction [...]
In Vitro Efficacies of Nitazoxanide and Other Thiazolides againstNeospora caninumTachyzoites Reveal Antiparasitic Activity Independent of the Nitro Group (2005)

The thiazolide nitazoxanide [2-acetolyloxy-N-(5-nitro-2-thiazolyl)benzamide] (NTZ) exhibits a broad spectrum of activities against a wide variety of intestinal and tissue-dwelling helminths, protozoa, and enteric bacteria infecting animals and humans. The drug has been postulated to act via reduction of its nitro group by nitroreductases, including pyruvate ferredoxin oxidoreductase. In this study, we investigated the efficacies of nitazoxanide and a number of other thiazolides against Neospora caninum tachyzoites in vitro. We employed real-time-PCR-based monitoring of tachyzoite adhesion, invasion, and intracellular proliferation, as well as electron microscopic visualization of the effects imposed by nitazoxanide. In addition, we investigated several modified versions of this drug. These modifications included on one hand the replacement of the nitro group on the thiazole ring with a bromide, thus removing the most reactive group, and on the other hand the differential positioning of methyl groups on the salicylate ring. We show that the thiazole-associated nitro group is not necessarily required for the action of the drug and that methylation of the salicylate ring can result in complete abrogation of the antiparasitic activity, depending on the positioning of the methyl group. These findings indicate that other mechanisms besides the proposed mode of action involving the pyruvate ferredoxin oxidoreductase enzyme could be responsible for the wide spectrum of antiparasitic activity of NTZ and that modifications in the benzene ring could be important in these alternative mechanisms.
A Study of Small Car Consumer Preference in Pune City (2013)

Indian Automobile small car business is influenced by the presence of many national and multi-national manufactures after liberalization in 1991. The presence of the many manufacturers and variants within the city provides several decision options to the customers as they supply similar product proposition, creating the passenger automotive small car market highly competitive Customers now search for those differentiating parameters, which may help them to choose among the alternative products available in the market. The purpose of this paper is to come with the identification of parameter that influence the customer purchase preference behavior patterns of passenger automobile small car owners within the city of Pune. Of greatest interest to the current study is the impact of demographic variables and income affecting the vehicle selection of small cars.
A 3.9 mW Bluetooth Low-Energy Transmitter Using All-Digital PLL-Based Direct FSK Modulation in 55 nm CMOS (2018)

This paper presents a low-power frequency-shift keying (FSK) transmitter (TX) with an all-digital phase locked loop (ADPLL) based on direct modulation for use in Bluetooth low energy application. A low power ADPLL with a Retimer, 2-stage time to digital converter, and gain estimation technique is proposed to achieve low-power direct FSK modulation at 1 Mbps data rate. A high-efficiency class-D power amplifier, with dual output power modes and a ramping digital filter (RDF), is proposed to reduce the spurious tones. The proposed TX is implemented on 1P6M 55-nm CMOS technology with a die size of 0.53 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The phase noise is -119 dBc/Hz at a 1 MHz offset with frequency of 2.44 GHz. TX output power levels of 1.6 and 10 dBm have a power consumption of 3.9 and 18 mW, respectively. The power control ranges for the 1.6 and 10 dBm modes are 25 and 23 dB, respectively. With the RDF, when the output level is +1.6 dBm, the second, and third harmonic distortions at the TX output are -44 and -49 dBm, respectively. The proposed TX achieves an error vector magnitude of 3.48% at an output power level of +1.6 dBm.
Atropisomerism in the Vaptan Class of Vasopressin Receptor Ligands: The Active Conformation Recognized by the Receptor (2011)

Latent chirality: Atropisomerism in the vaptan class of vasopressin receptor ligands with N-benzoyl benzo-fused seven-membered-ring nitrogen heterocycles was investigated by freezing the axis by ortho substitution. The aS/aR atropisomers caused by the ArN(CO) axis were separated to reveal that the vasopressin receptor recognizes the cis,aS conformation (see picture; R=CH3, X=CO, Y=H) when it binds to the ligand.
Interpreting measurements of cardiac function using vendor‐independent speckle tracking echocardiography in children: a prospective, blinded comparison with catheter‐derived measurements (2016)

Speckle-derived measurements of function in the LV have stronger correlation than the RV to catheter-derived measures. LV global LS has the strongest correlation with invasive function measures in children.
Einfluss des Beatmungssystems auf den Beatmungsspitzendruck und das Tidalvolumen in der Erstversorgung von unreifen Neugeborenen im Kreissaal (2005)

Einleitung: Hohe Beatmungsdrücke (PIP) und -volumina (VT) im Rahmen der Reanimation von Neugeborenen können zu Lungenschäden führen. Es galt zu prüfen, wie sich ein druckbegrentes System (Neopuff, Fisher&Paykel) gegenüber dem Laerdal-Beutel auf PIP und VT auswirkt.
Povetacicept, an Enhanced Dual APRIL/BAFF Antagonist That Modulates B Lymphocytes and Pathogenic Autoantibodies for the Treatment of Lupus and Other B Cell–Related Autoimmune Diseases (2023)

Enhanced APRIL and BAFF inhibition by povetacicept led to greater inhibition of B cell populations critical for autoantibody production compared to WT TACI-Fc and CD20-, APRIL-, or BAFF-selective inhibitors. Potent, dual inhibition by povetacicept has the potential to significantly improve clinical outcomes in autoantibody-related autoimmune diseases.
Charge transport in a double-layered enamel insulation during surface potential decay (2018)

This work presents a numerical model for studying charge dynamics during decay of pre-deposited surface charges on an enamel insulation comprising two layers of different materials. It is shown that the considered surface charge decay is dominated by charge injection from insulation surface into the bulk and the drift of injected carriers along the direction of induced electric field. These features allow for estimating charge carriers' mobilities in the studied insulation. The developed model incorporates experimental outcomes as well as the proposed effect of an internal interface between insulating layers on hindering charge transport through the bulk. The transient process of charge accumulation at the internal interface is exhibited and correlated with the well-known Maxwell-Wagner-Sillars polarization model. Contribution of charge injection at each insulation surface into the bulk to the measured potential decay is evaluated and compared.
A new complementary symmetrical structure of using dual magnetic cores for open loop Hall-Effect current sensors (2015)

In this paper, a new complementary symmetrical structure of using dual magnetic cores for open loop Hall-Effect current sensors is proposed to reduce the influence of the position change of primary current carrying conductor, which cannot be compensated in signal processing circuit. Magnetic field simulations by using Ansoft Maxwell are made to evaluate the influence from the magnetic fields of the core air gap, as the conductor changes its position inside the core. Both simulation and the testing results show that the influence is obviously reduced by a dual cores structure, and the accuracy of open loop Hall-Effect current sensor is improved to +-0.5%.
Heparin induced thrombocytopenia (Type II) in neonates and young children undergoing congenital cardiac surgery with Lepirudin for anticoagulation, report of 2 cases (2004)

Lepirudin is used for Heparin induced thrombocytopenia (HIT) and extra corporal circulation (ECC) in adults. There is only little experience in young children and neonates. We report 2 cases with application of Lepirudin for cardiopulmonary bypass (CPB) administered in dosages for adults. As described before, even neonates may develope HIT antibodies.
Alternative Splicing Targeting the hTAF4-TAFH Domain of TAF4 Represses Proliferation and Accelerates Chondrogenic Differentiation of Human Mesenchymal Stem Cells (2013)

Transcription factor IID (TFIID) activity can be regulated by cellular signals to specifically alter transcription of particular subsets of genes. Alternative splicing of TFIID subunits is often the result of external stimulation of upstream signaling pathways. We studied tissue distribution and cellular expression of different splice variants of TFIID subunit TAF4 mRNA and biochemical properties of its isoforms in human mesenchymal stem cells (hMSCs) to reveal the role of different isoforms of TAF4 in the regulation of proliferation and differentiation. Expression of TAF4 transcripts with exons VI or VII deleted, which results in a structurally modified hTAF4-TAFH domain, increases during early differentiation of hMSCs into osteoblasts, adipocytes and chondrocytes. Functional analysis data reveals that TAF4 isoforms with the deleted hTAF4-TAFH domain repress proliferation of hMSCs and preferentially promote chondrogenic differentiation at the expense of other developmental pathways. This study also provides initial data showing possible cross-talks between TAF4 and TP53 activity and switching between canonical and non-canonical WNT signaling in the processes of proliferation and differentiation of hMSCs. We propose that TAF4 isoforms generated by the alternative splicing participate in the conversion of the cellular transcriptional programs from the maintenance of stem cell state to differentiation, particularly differentiation along the chondrogenic pathway.
Correlations between growth mode and structural and optical properties of GaInNAs quantum wells grown by MBE (2003)

The GaInNAs (GINA) quaternary alloy has been intensively studied in the last years because of its promises for developing GaAs-based long-wavelength laser application. Indeed, high performance GINA-based laser structures have been demonstrated in the range of 1.3 /spl mu/m.
Discontinuous Buckling of Wide Beams and Metabeams (2015)

We uncover how nonlinearities dramatically alter the buckling of elastic beams. First, we show experimentally that sufficiently wide ordinary elastic beams and specifically designed metabeams-beams made from a mechanical metamaterial-exhibit discontinuous buckling, an unstable form of buckling where the postbuckling stiffness is negative. Then we use simulations to uncover the crucial role of nonlinearities, and show that beams made from increasingly nonlinear materials exhibit an increasingly negative postbuckling slope. Finally, we demonstrate that for sufficiently strong nonlinearity, we can observe discontinuous buckling for metabeams as slender as 1% numerically and 5% experimentally.
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice (2011)

The Ten-Eleven-Translocation 2 (TET2) gene encodes a member of TET family enzymes that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Somatic loss-of-function mutations of TET2 are frequently observed in patients with diverse myeloid malignancies, including myelodysplastic syndromes, myeloproliferative neoplasms, and chronic myelomonocytic leukemia. By analyzing mice with targeted disruption of the Tet2 catalytic domain, we show here that Tet2 is a critical regulator of self-renewal and differentiation of hematopoietic stem cells (HSCs). Tet2 deficiency led to decreased genomic levels of 5hmC and augmented the size of the hematopoietic stem/progenitor cell pool in a cell-autonomous manner. In competitive transplantation assays, Tet2-deficient HSCs were capable of multilineage reconstitution and possessed a competitive advantage over wild-type HSCs, resulting in enhanced hematopoiesis into both lymphoid and myeloid lineages. In vitro, Tet2 deficiency delayed HSC differentiation and skewed development toward the monocyte/macrophage lineage. Our data indicate that Tet2 has a critical role in regulating the expansion and function of HSCs, presumably by controlling 5hmC levels at genes important for the self-renewal, proliferation, and differentiation of HSCs.