gebhart/patrepeval huggingface dataset:
Effect of a deproteinized blood extract on experimental granulation tissue. (1979)

The present work was undertaken to study the effects of a deproteinized extract of calves' blood (Solcoseryl) on developing granulation tissue in rats. Cylindrical hollow viscose cellulose sponge implants were used as an inductive matrix for the growth of granulation tissue. In the first, sham group the implants were treated daily by withdrawing 1 ml of wound fluid from the central dead space of the implant and then re-injecting the fluid. In the second, experimental group the aspirated wound fluid was replaced by a corresponding volume or Solcoseryl. Analyses of wound fluid and granulation tissue were carried out 4, 10 and 21 days after implantation. A statistically significant increase of granulation tissue hemoglobin (+21%) was observed at 10 days in the Solcoseryl group as compared with the sham-treated rats, indicating an enhanced capillary ingrowth. Concurrently, the mean amount of DNA in the Solcoseryl-treated tissues was elevated by 48% over the level of the sham-treated group, demonstrating an augmented cellularity of granulation tissue. At 21 days the mean amount of collagen hydroxyproline of the Solcoseryl group was 31% above the level measured in the sham-treated animals. PO2, PCO2 and pH in the wound fluid and the amounts of RNA and uronic acids showed no essential differences between the two groups. These data demonstrate a stimulatory effect of Solcoseryl on several aspects of granulation tissue formation: augmented vascularization, elevated cellularity and subsequent enhancement in the accumulation of collagen.
Optimal Launch Vehicle Size Determination for Moon-Mars Transportation Architectures (2005)

NASA’s human Lunar and Mars exploration (HLE/HME) program requires a sustainable and affordable transportation system between Earth and Moon/Mars. A crucial element of this system is the launch vehicle. Much debate has centered on the trade between expendable launch vehicles and heavy-lifters; however, arguments to date have been largely qualitative or limited in scope. This paper provides a quantitative enumeration of the launch vehicle trade space (in terms of both cost and risk), based on a generalizable process for generating launch manifests from transportation architectures (sets of vehicles for carrying out Lunar/Mars missions). For the baseline HLE/HME architecture considered here, an optimal launch vehicle size is found at approximately 82 metric tons; a 28-mt EELV emerges as another good option. The results show optimal launch vehicle selection is highly dependent on the transportation architecture. Therefore, launch vehicle selection should be considered an integral part of the design of the Moon/Mars exploration transportation system.
Ferroelectric polymer Langmuir-Blodgett films for nonvolatile memory applications (2005)

We review the potential for integrating ferroelectric polymer Langmuir-Blodgett (LB) films with semiconductor technology to produce nonvolatile ferroelectric random-access memory (NV-FRAM or NV-FeRAM) and data-storage devices. The prototype material is a copolymer consisting of 70% vinylidene fluoride (VDF) and 30% trifluoroethylene (TrFE), or P(VDF-TrFE 70:30). Recent work with LB films and more conventional solvent-formed films shows that the VDF copolymers are promising materials for nonvolatile memory applications. The prototype device is the metal-ferroelectric-insulator-semiconductor (MFIS) capacitance memory. Field-effect transistor (FET)-based devices are also discussed. The LB films afford devices with low-voltage operation, but there are two important technical hurdles that must be surmounted. First, an appropriate method must be found to control switching dynamics in the LB copolymer films. Second, the LB technology must be scaled up and incorporated into the semiconductor-manufacturing process, but since there is no precedent for mass production of LB films, it is difficult to project how long this will take.
Compound parabolic concentrator probe for efficient light collection in spectroscopy of biological tissue (1996)

We describe a compound parabolic concentrator (CPC)-based probe for enhanced signal collection in the spectroscopy of biological tissues. Theoretical considerations governing signal enhancement compared with conventional collection methods are given. A ray-tracing program was used to analyze the throughput of CPC's with shape deviations and surface imperfections. A modified CPC shape with 99% throughput was discovered. A 4.4-mm-long CPC was manufactured and incorporated into an optical fiber-based near-infrared Raman spectrometer system. For human tissue samples, light collection was enhanced by a factor of 7 compared with collection with 0.29-NA optical fibers.
Design and Implementation of the Information Literacy Evaluation System for High School Students (2017)

High school is the key period of the formation of student information literacy, reasonable and scientific evaluation of learners' information literacy is essential. According to the evaluation index system of domestic information literacy is not perfect, the phenomenon of more traditional evaluation methods, through literature research, expert consultation and practice research, the study developed the index assessment of information literacy of high school students, designed and developed the system of information literacy assessment in senior high school students to realize the data acquisition online and the results of visualization. Also, the system can show the different views of the index and score ranking from the dimensions of county, school, grade, class and gender. The practice result showed that the system could meet the requirements of the information literacy assessment, make positive effects on the students' information literacy level, and provide effective decision-making support for the department of education.
The role of protein tyrosine phosphatase 1B in Ras signaling (2004)

Protein tyrosine phosphatase (PTP) 1B has been implicated as a negative regulator of multiple signaling pathways downstream of receptor tyrosine kinases. Inhibition of this enzyme was initially thought to potentially lead to increased oncogenic signaling and tumorigenesis. Surprisingly, we show that platelet-derived growth factor-stimulated extracellular-regulated kinase signaling in PTP1B-deficient cells is not significantly hyperactivated. Moreover, these cells exhibit decreased Ras activity and reduced proliferation by way of previously uncharacterized pathways. On immortalization, PTP1B-deficient fibroblasts display increased expression of Ras GTPase-activating protein (p120RasGAP). Furthermore, we demonstrate that p62Dok (downstream of tyrosine kinase) is a putative substrate of PTP1B and that tyrosine phosphorylation of p62Dok is indeed increased in PTP1B-deficient cells. Consistent with the decreased Ras activity in cells lacking PTP1B, introduction of constitutively activated Ras restored extracellular-regulated kinase signaling and their proliferative potential to those of WT cells. These results indicate that loss of PTP1B can lead to decreased Ras signaling, despite enhanced signaling of other pathways. This finding may in part explain the absence of increased tumor incidence in PTP1B-deficient mice. Thus, PTP1B can positively regulate Ras activity by acting on pathways distal to those of receptor tyrosine kinases.
Book reviews (1992)

The pale blue cover of this slim-volume seems like an old friend, and its aquaintance does not disappoint. The 156 pages of text provide a lively update on interventional radiology of the biliary tract. There are contributions from seven countries, beginning with a vivid account of the final illness of the exiled Shah of Persia in 1979. Burhenne suggests that the radiologically controlled removal of a retained common duct stone in the Shah and its subsequent worldwide press coverage marked the start of biliary tract interventional radiology, and who would disagree?
Devengo y no sujeción en el Impuesto Especial de Hidrocarburos. (A propósito de la STJCE de 18 de diciembre de 2007) (2010)

Biosynthesis of the red, tripyrrole antibiotic prodigiosin (Pig) by Serratia sp. ATCC 39006 (39006) is controlled by a complex regulatory network involving an N-acyl homoserine lactone (N-AHL) quorum-sensing system, at least two separate two-component signal transduction systems and a multitude of other regulators. In this study, a new transcriptional activator, PigT, and a physiological cue (gluconate), which are involved in an independent pathway controlling Pig biosynthesis, have been characterized. PigT, a GntR homologue, activates transcription of the pigA-O biosynthetic operon in the absence of gluconate. However, addition of gluconate to the growth medium of 39006 repressed transcription of pigA-O, via a PigT-dependent mechanism, resulting in a decrease in Pig production. Finally, expression of the pigT transcript was shown to be maximal in exponential phase, preceding the onset of Pig production. This work expands our understanding of both the physiological and genetic factors that impinge on the biosynthesis of the secondary metabolite Pig in 39006.
<title>Novel cluster-based probability model for texture synthesis, classification, and compression</title> (1993)

We present a new probabilistic modeling technique for high-dimensional vector sources, and consider its application to the problems of texture synthesis, classification, and compression. Our model combines kernel estimation with clustering, to obtain a semiparametric probability mass function estimate which summarizes -- rather than contains -- the training data. Because the model is cluster based, it is inferable from a limited set of training data, despite the model's high dimensionality. Moreover, its functional form allows recursive implementation that avoids exponential growth in required memory as the number of dimensions increases. Experimental results are presented for each of the three applications considered.
Rethinking Medical Training — The Critical Work Ahead (2002)

What physicians do on a daily basis has evolved considerably in the past quarter-century, but the format of postgraduate medical training has changed relatively little. When we trained in internal medicine in the 1970s, our clinical rotations included every-second-or-third-night on-call schedules. At that time, completing all the tasks expected of a trainee routinely required 100 hours of work a week or more. Although the duty hours of house-staff trainees in internal medicine have decreased during the past 25 years, they remain substantial. Moreover, many of the other building blocks of medical training — work rounds, attending rounds, specialty conferences, and . . .
Donor Nephrectomy:: A Comparison of Techniques and Results of Open, Hand Assisted and Full Laparoscopic Nephrectomy (2004)

Our data show no significant difference in graft function between LAP and OD. LAP and HAL were safe and complications were minimal. The main difference was that patients treated with LAP and HAL returned to normal physical activity and work significantly earlier than those who underwent OD.
Non-melt processible fluoroplastics : the definitive user's guide and databook (2000)

Fundamentals * Properties * Classification * Monomers * Polmerizations * Commercial Grades * Fabrication and Processing - Granular Resins, Fine Powder Resins, Dispersions * Processing of RTFE * Fluoroadditives * Filled Compounds * Chemical Properties * Fabrication Techniques * Applications * Safety, Disposal and Recycling.
Theranostic laser system for multi-function drug activation and monitoring (2022)

Here we present novel cloud-connected theranostic medical laser platform specifically designed for activating and simultaneously monitoring multi-component oncological treatment processes. It may incorporate multiple wavelengths for inducing therapeutic effect or monitoring treatment in real-time. The same low-invasive optical probers can be used for treatment and monitoring. We believe that this theranostic laser platform will allow clinicians to develop improved treatment outcomes for cancer patients that may be based on machine learning and AI in the future.
The Pyrolysis of Formaldehyde1,2 (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Pyrolysis of Formaldehyde1,2Ralph Klein, Milton D. Scheer, and Louis J. SchoenCite this: J. Am. Chem. Soc. 1956, 78, 1, 50–52Publication Date (Print):January 1, 1956Publication History Published online1 May 2002Published inissue 1 January 1956https://pubs.acs.org/doi/10.1021/ja01582a013https://doi.org/10.1021/ja01582a013research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermal Decomposition Pathways in Nitramine Propellants. (1995)

Abstract : We have investigated intermediates and products in the thermal decomposition of RDX vapor, using a variety of experimental microwave techniques previously employed in our laboratory in studies of pyrolysis decomposition of organic amines. We used microwave spectroscopy to determine the chemical composition of the decomposition of nitramines by pyrolysis methods and identify the products in the thermal decomposition processes. The objective was to determine the validity of proposed decomposition mechanisms, and to identify new reaction products or pathways. jg p.1
MicroRNA-20a Constrains p300-Driven Myocardial Angiogenic Transcription by Direct Targeting of p300 (2013)

p300 drives an angiogenic transcription program during hypertrophy that is fine-tuned in part through direct repression of p300 by miR-20a.
Surface Charge-Modification Prevents Sequestration and Enhances Tumor-Cell Specificity of a Recombinant Granzyme B–TGFα Fusion Protein (2012)

The serine protease granzyme B (GrB) plays an important role in the immune defense mediated by cytotoxic lymphocytes. Recombinant derivatives of this pro-apoptotic protein fused to tumor-targeting ligands hold promise for cancer therapy, but their applicability may be limited by promiscuous binding to nontarget tissues via electrostatic interactions. Here, we investigated cell binding and specific cytotoxicity of chimeric molecules consisting of wild-type or surface-charge-modified human GrB and the natural EGFR ligand TGFα for tumor targeting. We mutated two cationic heparin-binding motifs responsible for electrostatic interactions of GrB with cell surface structures, and genetically fused the resulting GrBcs derivative to TGFα for expression in the yeast Pichia pastoris. Purified GrBcs-TGFα (GrBcs-T) and a corresponding fusion protein employing wild-type GrB (GrB-T) displayed similar enzymatic activity and targeted cytotoxicity against EGFR-overexpressing breast carcinoma cells in the presence of an endosomolytic reagent. However, unspecific binding of the modified GrBcs-T variant to EGFR-negative cells was dramatically reduced, preventing the sequestration by nontarget cells in mixed cell cultures and increasing tumor-cell specificity. Likewise, modification of the GrB domain alleviated unspecific extracellular effects such as cell detachment indicative of extracellular matrix degradation. Our data demonstrate improved selectivity and functionality of surface-charge-modified GrBcs, suggesting this strategy as a general approach for the development of optimized GrB fusion proteins for therapeutic applications.
Absorptions‐ und Fluoreszenzspektren sowie Dissoziationskonstanten der Grund‐ und ersten angeregten Singulettzustände von 4′‐Hydroxyflavon und 4′‐Methoxyflavon [1] (1982)

Abstract The absorption and fluorescence spectra of 4′‐hydroxyflavone and 4′‐methoxyflavone have been studied as a function of the acidity (pH or H o ) of the solution. Dissociation constants have been determined for the ground and first excited singlet state. The values are compared with those obtained from Förster‐Weller calculations.—The p K a 's obtained by fluorimetry are rather similar to the ground state p K a 's, which indicates a rapid deactivation of the S 1 ‐state, before prototropic equilibration is complete.—On changing from protic to deuterated solvents partially strong effects are observed with respect to the fluorescence intensity, but also to the shape of the curves. It is evident, that proton transfer processes in the excited state significantly contribute to fluorescence quenching, thus making the fluorescence quantum yields strongly acidity dependent.
The Lord's prayer (1937)

Journal Article The Lord's prayer Get access Lawrence Phillips Lawrence Phillips Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 173, Issue 10, 4 September 1937, Page 176, https://doi.org/10.1093/nq/173.10.176b Published: 04 September 1937
Registration of a Cowpea [Vigna unguiculata (L.) Walp.] Multiparent Advanced Generation Intercross (MAGIC) Population (2019)

The cowpea [ Vigna unguiculata (L.) Walp] multiparent advanced generation intercross (MAGIC) population (Reg. No. MP‐1, NSL 526803 MAP) consists of 305 recombinant inbred lines (RILs). The population was constructed from eight elite parents that are genetically diverse and carry combinations of abiotic and biotic stress resistance traits relevant to cowpea improvement in sub‐Saharan Africa. The eight parents were intermated using structured crosses to ensure the population would have balanced representation from each of the founder parents, followed by seven rounds of single‐seed descent. The resulting F 8 RILs each carry a mosaic of genome blocks contributed from all founders as revealed by high‐resolution single nucleotide polymorphism genotyping. The RILs are diverse in agronomic traits, including flowering time, growth habit, maturity, yield potential, and seed characteristics across environments. Due to its broad genetic base, this cowpea MAGIC population will simplify and facilitate community‐wide discovery of marker‐trait associations and fine mapping for gene discovery.
2415 Effect of Tip Clearance on Structure of Rotating Stall Cell in an Axial Flow Compressor Rotor (2006)

Effect of the tip clearance on the flow structure of rotating stall cell has been investigated experimentally in an axial flow compressor rotor. In the low-speed research compressor rotor tested, the number of multiple stall cells with short length-scale and the rotating speed change with the tip clearance. For two different tip clearances, the flow structure of rotating stall cell was analyzed by measuring the pressure distribution on the casing wall and the velocity distributions upstream and downstream of the rotor, using 'Synchronous Field Measurement' and 'Double Phase-Locked Averaging Technique'.
Black phosphorus composites with engineered interfaces for high-rate high-capacity lithium storage (2020)

High-rate lithium (Li) ion batteries that can be charged in minutes and store enough energy for a 350-mile driving range are highly desired for all-electric vehicles. A high charging rate usually leads to sacrifices in capacity and cycling stability. We report use of black phosphorus (BP) as the active anode for high-rate, high-capacity Li storage. The formation of covalent bonds with graphitic carbon restrains edge reconstruction in layered BP particles to ensure open edges for fast Li<sup>+</sup> entry; the coating of the covalently bonded BP-graphite particles with electrolyte-swollen polyaniline yields a stable solid-electrolyte interphase and inhibits the continuous growth of poorly conducting Li fluorides and carbonates to ensure efficient Li<sup>+</sup> transport. The resultant composite anode demonstrates an excellent combination of capacity, rate, and cycling endurance.
Development and Characterization of Highly Efficient Mimics of the Rice Growth Regulator Zaxinone for Basic Research and Agricultural Applications (2019)

Carotenoids are the precursor of several plant hormones and signaling molecules, which play important roles in literally all aspects of plants’ life. Recently, we have identified zaxinone, an apocarotenoid formed by the carotenoid cleavage enzyme Zaxinone Synthase (ZAS), as a novel-signaling molecule required for rice growth and development. Investigation of a rice zas mutant and zaxinone treatment demonstrated that zaxinone is a negative regulator of SL biosynthesis, lowering SL content and alleviating infestation by the parasitic weed Striga. Now we further developed zaxinone-mimics with relatively simple structure that can be employed in fundamental research and large scale agriculture applications. Comparative studies demonstrated the two identified mimics of zaxinone (MiZaxs) appeared highly efficient that can cause a significant increase in root growth and biomass in wild type rice and restored the growth retardation and lowered SL content in the zas mutant. Treatment with MiZaxs significantly decreased SL release in wild-type rice and, accordingly, suppressed the infestation with the parasitic plant Striga.
Contributions of anoxygenic and oxygenic phototrophy and chemolithotrophy to carbon and oxygen fluxes in aquatic environments (2009)

Estimates of aquatic primary productivity at local, regional or global scales commonly concentrate on oxygenic photolithotrophy. The analysis presented here briefly considers the occurrence and metabolism of other autotrophs sensu lato, i.e. not just the organisms with an autotrophic inorganic carbon assimilation machinery. These other autotrophs include chemolithotrophs and anoxygenic photolithotrophs, of which some use the photosynthetic carbon reduction cycle as do oxygenic photolithotrophs, while others use one of 4 other pathways. The category of other autotrophs also includes organisms that possess photochemical energy transduction machinery but lack autotrophic carbon assimilation; light stimulates the growth rates of these autotrophs and/or increases the fraction of the organic carbon substrate used that is converted into cell material when using light energy. Organisms lacking autotrophic inorganic carbon assimilation influence food webs by increasing the rate, or efficiency, of conversion of dissolved organic carbon ultimately derived from autotrophic inorganic carbon assimilation into particulate organic carbon. Chemolithotrophs and anoxygenic autotrophs today depend on the activities of oxygenic chemolithotrophs for one or more of their growth substrates, and thus contribute to global net primary productivity but not to global gross primary productivity. Global net aquatic primary productivity by oxygenic photolithotrophs is at least 50 Pg C yr -1 , while chemolithotrophs and anoxygenic photolithotrophs together contribute about 0.40 Pg C yr -1 . Before the occurrence of oxygenic photolithotrophs in the Archaean, chemolithotrophs and anoxygenic photolithotrophs had a net primary productivity of about 3.4 Pg C yr -1 , which is higher than the present values largely because anoxygenic photolithotrophs were able to inhabit the euphotic zone worldwide.