gebhart/patrepeval huggingface dataset:
Convergence of a Numerical Scheme for Stratigraphic Modeling (2005)

In this paper, we consider a multilithology diffusion model used in the field of stratigraphic basin simulations to simulate large scale depositional transport processes of sediments described as a mixture of L lithologies. This model is a simplified one for which the surficial fluxes are proportional to the slope of the topography and to a lithology fraction with unitary diffusion coefficients. The main variables of the system are the sediment thickness h, the L surface concentrations cis in lithology i of the sediments at the top of the basin, and the L concentrations ci in lithology i in the sediments inside the basin. For this simplified model, the sediment thickness decouples from the other unknowns and satisfies a linear parabolic equation. The remaining equations account for the mass conservation of the lithologies, and couple, for each lithology, a first order linear equation for cis with a linear advection equation for ci for which cis appears as an input boundary condition. For this coupled system, a weak formulation is introduced. The system is discretized by an implicit time integration and a cell centered finite volume method. This numerical scheme is shown to satisfy stability estimates and to converge, up to a subsequence, to a weak solution of the problem.
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis (2018)

Our work has demonstrated for the first time that multiple inflammasomes are associated with AIT pathogenesis. The identified NLRP3, NLRP1, NLRC4, AIM2 inflammasomes and their downstream cytokines may represent potential therapeutic targets and biomarkers of AIT.
Optimierung der Leistungsfähigkeit von elektrothermischen Polymeraktoren (2017)

In dieser Arbeit wird die Optimierung von elektrothermischen Mikroaktoren auf Basis des Duromers SU-8 2025 vorgestellt. Dabei stehen im Fokus die Maximierung der Aktorauslenkung sowie die Minimierung des parasitären Effekts der Nulllagenverschiebung, die eine erhebliche Störgröße während des Aktorbetriebs darstellt. Die physikalischen Gründe für die Nulllagenverschiebung werden erläutert und experimentell nachgewiesen. Es wird eine bis zu 75 % größere laterale Aktorauslenkung erreicht und die Nulllagenverschiebung wird um ca. 30 % reduziert.
Inhibition by azelastine of the immunologically induced histamine release from isolated guinea pig mast cells. (1981)

4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone (azelastine, A 5610) did not affect the spontaneous histamine release but inhibited effectively the allergic histamine release from isolated mesenteric mast cells of actively sensitized guinea pigs. At 10(-6) mol/l concentration the inhibition was almost equal to that caused by adrenaline (10(-8) mol/l).
Forum Bildverarbeitung 2016 (2016)

Bildverarbeitung spielt in vielen Bereichen der Technik zur schnellen und berührungslosen Datenerfassung eine Schlüsselrolle. Der vorliegende Tagungsband des „Forums Bildverarbeitung“, das am 1. und 2. Dezember 2016 in Karlsruhe als Veranstaltung des Karlsruher Instituts für Technologie und des Fraunhofer-Instituts für Optronik, Systemtechnik und Bildauswertung stattfand, enthält die Aufsätze der eingegangenen Beiträge. Darin wird über aktuelle Trends und Lösungen der Bildverarbeitung berichtet.
Enzyme Studies in Muscular Dystrophy VI (1965)

Alterations in the activities of two acid hydrolases, cathepsin and acid deoxyribonuclease, and in noncollagen protein nitrogen and deoxyribonucleic acid content of breast muscle of chickens with hereditary muscular dystrophy have been investigated from the 14-day embryo to 1-year-old chickens. In general, dystrophic muscle has a lower noncollagen protein nitrogen content, and higher deoxyribonucleic acid content, deoxyribonuclease, and cathepsin activity than does control muscle. The relative order of appearance of these changes is deoxyribonucleic acid content, deoxyribonuclease activity, noncollagen protein nitrogen content, cathepsin activity. Cathepsin and deoxyribonuclease values for heterozygous and homozygous controls are essentially the same. Noncollagen protein nitrogen and deoxyribonucleic acid content of heterozygous control muscle are generally similar to those of the homozygous, although by 1 to 3 months they tend to approach dystrophic levels.
Optimal combinational quota‐share and excess‐of‐loss reinsurance policies in a dynamic setting (2006)

Abstract In this paper, we describe a large insurance company's surplus by a Brownian motion with positive drift, which is the approximation of a classical risk process. The problem of minimizing the probability of ruin by controlling the combinational quota‐share and excess‐of‐loss reinsurance strategy is considered. We show that the optimal combinational reinsurance strategy must be the pure excess‐of‐loss reinsurance strategy. Moreover, we give an explicit solution for the optimal reinsurance strategy. Copyright © 2006 John Wiley &amp; Sons, Ltd.
Distinct Antifouling Mechanisms on Different Chain Densities of Zwitterionic Polymers (2022)

Antifouling polymer coating surfaces are used in widespread industries applications. Zwitterionic polymers have been identified as promising materials in developing polymer coating surfaces. Importantly, the density of the polymer chains is crucial for acquiring superior antifouling performance. This study introduces two different zwitterionic polymer density surfaces by applying molecular modeling tools. To assess the antifouling performance, we mimic static adsorption test, by placing the foulant model bovine serum albumin (BSA) on the surfaces. Our findings show that not only the density of the polymer chain affect antifouling performance, but also the initial orientation of the BSA on the surface. Moreover, at a high-density surface, the foulant either detaches from the surface or anchor on the surface. At low-density surface, the foulant does not detach from the surface, but either penetrates or anchors on the surface. The anchoring and the penetrating mechanisms are elucidated by the electrostatic interactions between the foulant and the surface. While the positively charged ammonium groups of the polymer play major role in the interactions with the negatively charged amino acids of the BSA, in the penetrating mechanism the ammonium groups play minor role in the interactions with the contact with the foulant. The sulfonate groups of the polymer pull the foulant in the penetrating mechanism. Our work supports the design of a high-density polymer chain surface coating to prevent fouling phenomenon. Our study provides for the first-time insights into the molecular mechanism by probing the interactions between BSA and the zwitterion surface, while testing high- and low-densities polymer chains.
Rheology of Glaze Suspensions (2003)

Abstract Rheological properties of suspensions and ceramic glaze slurries under steady flow conditions have been considered. Colloidal forces play an important role in the rheology of such ceramic slurries. Since the potential function characterizes the rheology of colloidal systems, a new dimensionless group, viz. potential number, is introduced within a dimensional analysis representing the relative significance of the potential to the Brownian energy. In order to relate the relative viscosity to other dimensionless groups, a new model is proposed by the inclusion of an extra term in addition to that of the hard‐sphere theory owing to the fact that the presence of colloidal forces always increases the fluid viscosity with respect to that predicted by the hard‐sphere. Steady viscosity measurements have been carried out on ceramic glaze suspensions at different volume fractions, particle diameters, and shear rates. Experimental results have been used to modify the model relating the relative viscosity to the Péclet number, potential number, volume fraction, and maximum packing fraction.
Novel Zinc Chelators Which Inhibit the Binding of HIV-EP1 (HIV Enhancer Binding Protein) to NF-.kappa.B Recognition Sequence (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel Zinc Chelators Which Inhibit the Binding of HIV-EP1 (HIV Enhancer Binding Protein) to NF-.kappa.B Recognition SequenceMasami Otsuka, Mikako Fujita, Yukio Sugiura, Shunsuke Ishii, Tsutomu Aoki, Tadashi Yamamoto, and Jun-ichiro InoueCite this: J. Med. Chem. 1994, 37, 25, 4267–4269Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/jm00051a002https://doi.org/10.1021/jm00051a002research-articleACS PublicationsRequest reuse permissionsArticle Views258Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Large Vortex Input in a Noise of Artifically Excited Subsonic Jet (2007)

The main goal of the paper is to assess the contribution of large-scale vortices to the noise of the subsonic turbulent jet in the selected frequency bands (Sh~0.2-0.45). The mechanism of sound radiation according to which a separate vortex structures itself can be a significant sound source is considered. Vortex core eigen-modes are responsible for noise radiation according to this mechanism. The work is subdivided on three coupling items: (i) theoretical investigation of noise radiation of separate vortex ring (especially little-known octupole contribution to sound radiation), (ii) visualization of large vortices in excited jet and (iii) experimental investigation of turbulent jet noise (subsonic jet with velocity 120m/s excited at 2032Hz) decomposed on the separate azimuthal components with the help of azimuthal decomposition technique (ADT). The careful comparison of these results gives the quantitative assessment of the contribution of vortex rings to the real subsonic jet noise and gives the main source localization. The proposed approach for jet noise modelling was additionally checked by measurements with two co-axial microphone arrays. Good agreement of azimuthal noise modelling using the same parameter set for two radial distances was demonstrated.
Improved thermoelectric properties in heavily doped FeGa3 (2015)

FeGa3, a hybridization gap semiconductor, has been substituted with an n-type dopant Ge to form a series of compositions FeGa3−xGex. Electrical and thermal transport properties of these compositions have been studied. Change in carrier density (n) is evident from the Hall measurements. The carrier density (n) can be as high as ∼1021 cm−3 in these compositions. In order to study the role of heavy doping on the thermoelectric properties of FeGa3, an alloy series Fe1−yCoyGa3−xGex has also been synthesized with higher concentrations of Ge (x = 0.1–0.35) and Co (y = 0.1–0.5). From resistivity and Seebeck coefficient measurements, it appears that heavy doping is accomplished by the simultaneous substitutions of Ge and Co. The systematic change in both resistivity (ρ) and Seebeck coefficient (α) is possibly due to change in the carrier density (n). The power factor (PF) α2/ρ improves steadily with increasing carrier density and the best PF ∼1.1 mW/m K2 is observed for the heavily doped compositions at 875 K. In the alloy series Fe1−yCoyGa3−xGex, thermal conductivity is also reduced substantially due to point defect scattering. Due to higher power factors, the figure of merit ZT improves to 0.25 at 875 K for the heavily doped compositions.
Conception and Design of a Hardware Simulator for Restoring Lost Biomechanical Function (2013)

The Prosthesis-User-in-the-Loop simulator concept represents an approach to integrate users to prosthetic development by a holistic simulation of gait with a prosthesis. It aims at a more user-centered design of lower limb prosthetic devices by utilizing user experience and assessment. As this requires a complex mechanical robot design and sophisticated control strategies that allow for restoring lost biomechanical function, this paper presents the conception and design of a hardware simulator for proof-of-concept studies of those issues. For those investigations, the ankle joints of healthy praticpants are locked mechanically to induce a temporary disability. The task of the simulator is to provide a simulation of physiological gait by artificially restoring ankle functionality. Therefore, the biody-namic behaviour of the locked ankle joint and the enviroment have to be mimicked mechnically. After introducing Prosthesis-User-in-the-Loop simulator idea, the conception of a proof-of-concept simulator is presented. From this, an analytical model is derived and inverse dynamics simulation are used for design. The resulting mechanism is limited to sagittal plane movements and thus has three degrees of freedom. The actuators are dimensioned to meet the requirements of walking motions in the human subject with maximum body height among the test population.
GeoCLR: Georeference Contrastive Learning for Efficient Seafloor Image Interpretation (2022)

This paper describes georeference contrastive learning of visual representation (GeoCLR) for efficient training of deep-learning convolutional neural networks (CNNs). The method leverages georeference information by generating a similar image pair using images taken of nearby locations, and contrasting these with an image pair that is far apart. The underlying assumption is that images gathered within a close distance are more likely to have similar visual appearance, where this can be reasonably satisfied in seafloor robotic imaging applications where image footprints are limited to edge lengths of a few meters and are taken so that they overlap along a vehicle's trajectory, whereas seafloor substrates and habitats have patch sizes that are far larger. A key advantage of this method is that it is self-supervised and does not require any human input for CNN training. The method is computationally efficient, where results can be generated between dives during multi-day autonomous underwater vehicle (AUV) missions using computational resources that would be accessible during most oceanic field trials. We apply GeoCLR to habitat classification on a dataset that consists of ~86,000 images gathered using an AUV. We demonstrate how the latent representations generated by GeoCLR can be used to efficiently guide human annotation efforts, where the semi-supervised framework improves classification accuracy by an average of 10.2% compared to the state-of-the-art SimCLR using the same CNN and equivalent number of human annotations for training.
A novel silicon microstrip termination structure with all p-type multiguard and scribe-line implants (2002)

A novel termination structure for silicon microstrip detectors is proposed, featuring all p-type multiguard and scribe-line implants, as well as inward metal field-plates providing almost complete coverage of the passivation-oxide external surface. The structure is intended for detector long-term stability improvement and fabrication-process simplification. Proper design of the multiguard layout enables a very stable behavior at relatively high bias voltages to be achieved both prior and after 1/spl times/10/sup 12/ cm/sup -2/ neutron irradiation.
FRAS1 knockdown reduces A549 cells migration and invasion through downregulation of FAK signaling. (2014)

Distal metastasis is the major cause of death for the vast majority of lung cancer patients. Many extracellular matrix (ECM)-related molecules are proposed to be associated with the migration and invasion of cancer cells. FRAS1 encodes an ECM protein, however, little is known about its function on tumorigenesis and metastasis of lung cancer. In this work, FRAS1 was silenced by shRNA in non-small cell lung cancer (NSCLC) A549 cell line. The capacities of A549 cells to migrate and invade were decreased markedly after FRAS1 knockdown. The shRNA knockdown of FRAS1 was found to be specific and had no effect on A549 cells proliferation. Western blot experiments demonstrated that FRAS1 knockdown inhibited FAK signaling but not Src signaling. Overall, we found that FRAS1 knockdown reduces A549 cells migration and invasion ability through downregulation of FAK signaling.
Scientific approaches to sound design (1999)

Sound design can be studied from various perspectives. This contribution gives an overview\nof four different scientific approaches. The first is the physical approach, in which sound production is physically modelled using mathematical equations or computer models of the\nsound-generating event. The second approach is concerned with perceptual concepts such as pitch and timbre. The psychophysicist is typically interested in perception thresholds, frequency and temporal resolution, just-noticeable differences, magnitude scaling, etc. The third approach, referred to as auditory scene analysis, studies the perceptual process in which some sound components are attributed to the same sound-generating event, while some others are perceptually attributed to different events. The last approach we will deal with is called the ecological approach. According to this approach, the listener does not so much listen to the pitch, the timbre, or the rhythm of the sound, but rather uses the physical cues in the sound to mentally reconstruct an image of the environment and of what happens in that environment. The implications of these different approaches for the design of soundscapes, non-speech audio, and of user-interface sounds in particular will be discussed.
Comparison of adequacy of anaesthesia monitoring with standard clinical practice monitoring during routine general anaesthesia (2020)

at ClinicalTrials.gov NCT01928875.
P182 : Madelung’s disease in Asian (2018)

Background: Madelung’s disease (MD) is an uncommon, benign disorder characterized by the presence of multiple, symmetric deposits of unencapsulated adipose. The etiology of lipoma tissue in MD remains controversial.
Objectives: The aim of this study is to investigate clinical and epidemiological features of Asian patients diagnosed with MD and compare these data to those of Mediterranean patients. Moreover, this article aims to re-examine the hypothesis that lipomas of MD originate from brown fat.
Methods: A single-institution, retrospective medical record review was conducted of 20 patients who were diagnosed with MD between January 1997 and August 2017. We obtained biopsy slides and stained them with Nuclear Factor-1A (NFIA) and Uncoupling protein-1 (UCP-1).
Results: The average of age was 64 and the most frequently affected area was neck. 2 patients (10%) were female, 10 patients were heavy drinkers of alcohol while 10 patients reported some degree of alcohol intake. 45% of patients have hepatic disease, only 25% of patients had a body mass index >25.
Conclusion: The onset of Asian patients seems to higher than that of Mediterranean patients. Alcoholism, hepatic diseases and severe obesities are less prevalent in Asian patients with MD. Although both NFIA and UCP-1 are stained with adipose tissue in all patients, intensity of staining was variable. NFIA, which is a transcription factor required for brown fat-specific gene expression is more sensitive for the detection of brown fat.
Antibiotic glycosyltransferases (2003)

In the biosynthesis of several classes of antibiotics, sugars are attached to aglycone scaffolds by antibiotic-specific glycosyltransferases in the latter stages of the pathways. Two glycosylation pathways will be examined: the glycopeptide antibiotics of the vancomycin class and the aminocoumarin antibiotics of the novobiocin class. An oxidatively cross-linked heptapeptide scaffold is sequentially glucosylated and vancosaminylated by GtfE and GtfD, respectively, in vancomycin maturation, while in chloroeremomycin assembly the same heptapeptide is glucosylated by GtfB, then epivancosaminylated at two distinct sites by GtfA and GtfC. The specificity and mechanism of these glycosyltransferases will be discussed. In novobiocin biosynthesis, three enzymes (NovM, NovP and NovN) are thought to act sequentially to transfer an L-noviose moiety to the novobiocic acid aglycone (NovM), followed by 4'-hydroxyl methylation (NovP) and 3'-hydroxyl carbamoylation to produce the mature antibiotic structure, targeting the GyrB subunit of DNA gyrase. Initial characterization of NovM and NovP will be discussed.
Volume substitution with 6% HES 130/0.4 in a balanced electrolyte solution in cardiac surgery (2006)

1Medical University, AKH, Vienna, Austria; 2Academic Hospital of the University of Cologne, Solingen, Germany; 3Clinical Affairs, Fresenius Kabi, Germany
Design of an equalizer using the DFE structure and the MMA algorithm (2002)

This paper proposes an equalizer using MMA (MultiModulus Algorithm) and LMS (Least Mean Square) algorithms and uses a DFE (Decision Feedback Equalizer) structure. The existing MMA equalizer uses two transversal filters but the proposed equalizer uses two DFE filter banks to improve the channel adaptive performance and to reduce the number of taps. The fabricated equalizer ASIC chip using the MMA and LMS algorithms operates at 8 MHz and provides 64 Mbps which is higher than existing equalizers. The chip uses the 0.35 /spl mu/m technology and has about 160000 gates.
A hybrid similarity matching algorithm for mapping and rading ontologies via a multi-agent system (2008)

In this paper, we present a hybrid similarity matching algorithm i.e. Semantic Relatedness Score (SRS) that is used to match ontological concepts and instances in the context of ontology evolution. We combine five out of thirteen well-tested semantic and syntactic algorithms to produce SRS. Specifically we focus on the issue of ontology upgrade and highlight how our hybrid matching algorithm produces higher precision and reliability compared to existing syntactical approaches. Managing evolution amongst shared ontologies is a laborious affair.

This paper extends ongoing work in the area and focuses on changes made in a shared ontology such as inclusion of new classes, renaming, deletion and modification of existing classes. Since these changes will adversely impact shared concepts, users would have to update their local ontologies to be consistent with changes in the shared ontology. As such, a less laborious method is needed for an ontologist to update his local ontology. This paper illustrates how a multi-agent system (MAS) can be deployed to achieve this goal. A semi-automated approach is presented where agent systems would filter concept changes based on SRS and recommend them to the ontologist for upgrade. A MAS prototype has been implemented in the Java Agent DEvelopment Framework (JADE) which is a FIPA standard for proof-of-concept.