gebhart/patrepeval huggingface dataset:
Self‐Assembly of Luminescent Platinum‐Salen Schiff‐Base Complexes (2007)

Abstract Treatment of K 2 PtCl 4 with the MeO‐salen Schiff base H 2 L [ H 2 L = N , N ′‐bis(3‐methoxysalicylidene)ethylene‐1,2‐diamine] gave the precursor complex PtL , which, upon recrystallization from two different solvent mixtures, afforded different solvate forms of PtL· H 2 O ( 1 ) and PtL· DMF ( 2 ) with different solid‐state colors. The self‐assembly of the PtL precursor with K 2 Pt(CN) 4 or K 2 Pd(CN) 4 leads to the isolation of isostructural compound [K 2 (PtL) 2 Pt(CN) 4 ]· 1.5H 2 O ( 3 ) or [K 2 (PtL) 2 Pd(CN) 4 ]· 1.5H 2 O ( 4 ), respectively. The solid‐state structures of 1 – 4 were established by X‐ray crystallography. It is interesting that the helix of the PtL units, along with the other two homochiral helical arrangements of K + and M 2+ (M = Pt or Pd) ions, can generate a unique “fake” example of a triple‐stranded helix in a 1‐D helical polymeric chain. Two such triple‐stranded helical chains intertwining one another can give rise to a double‐stranded helix formed by intermolecular weak C–H ··· N hydrogen‐bonding interactions with a long helical pitch of ca. 56 Å. The optical absorption and photoluminescence properties of 1 – 4 were also examined.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2008)
Detection of significant prostate cancer through magnetic resonance imaging targeted biopsy of PI-RADS3 lesions in African American patients based on prostate specific antigen density threshold of 0.15 ng/ml2: Analysis of patient population from the Vattikuti Urology Institute. (2020)

286 Background: A prostate specific antigen density (PSAD) threshold of 0.15 ng/ml 2 have been suggested for significant cancer detection in PI-RADS 3 lesions to avoid unnecessary magnetic resonance imaging targeted biopsy (MRI-TB) of these lesions. However, the performance of this threshold in African American (AA) patients is not well characterized. Methods: We analyzed our institutional data base of MRI-TB to identify the rate of significant prostate cancer (Pca) detection in PI-RADS3 lesions in AA patients stratified by PSAD threshold of &lt; 0.15 vs. ≥0.15 ng/ml 2 and lesion size of &lt; 1 cm vs ≥ 1 cm. Significant prostate cancer was defined as Gleason grade group 2 or higher on MRI-TB of the PI-RADS 3 lesion. Results: Of 768 patients included in the database, 211 (27.5%) patients identified themselves as AAs. Mean age of AA patients was 63 years and mean PSAD was 0.21. Sixty nine (32.7%) AA patients were found to have PI-RADS 3 lesions. Mean PSAD of AA patients with PI-RADS 3 lesions was 0.21 ng/ml 2 as well. Fifty percent of AA patients with PI-RADS 3 lesions had PSAD ≥0.15 ng/ml 2 . Significant Pca detection rate for AA patients with PI-RADS 3 lesions was 9% for PSAD of ≥ 0.15 vs. 0.03% percent for AA patients with PSAD &lt; 0.15 ng/ml 2 (OR 7.056, CI 1.017-167.9, P=0.04). Stratification by lesion size (&lt; 1 cm vs. &gt; 1 cm) resulted in missing 0% percentage of significant Pca when only AA patients with PSAD ≥ 0.15 ng/ml2 and lesion size ≥ 1 cm received MRI-TB. Conclusions: We report on the performance of a reported PSAD density threshold in detecting significant Pca in one of the largest series of AA patients receiving MRI-TB of the prostate. Our results have direct clinical implications when counseling AA patients with PI-RADS 3 lesion on whether they should undergo MRI-TB of such lesions.
Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease (2019)

The results of this study are consistent with target engagement of brain insulin, Akt, and mTOR signaling pathways by exenatide and provide a mechanistic context for the clinical findings of the Exenatide-PD trial. This study suggests the potential of using exosome-based biomarkers as objective measures of target engagement in clinical trials using drugs that target neuronal pathways.
The Influence of lnterleukin-2 on the Release of Somatostatin and Growth Hormone-Releasing Hormone by Mediobasal Hypothalamus (1993)

Interleukin-2 (IL-2), which plays a major role in the bidirectional intercellular communication between the neuroendocrine and immune systems, suppressed the release of GH from anterior pituitary halves at femtomolar concentrations. It is well established that the release of GH from the anterior pituitary is regulated by growth hormone releasing hormone (GRH) and growth hormone release-inhibiting hormone (somatostatin). Consequently, we studied the possible effect of IL-2 on the release of somatostatin and GRH from the mediobasal hypothalamus (MBH) in vitro. Single MBHs were incubated with fresh Krebs-Ringer bicarbonate (KRB) buffer alone or KRB containing different concentrations of IL-2 (10(-15)-10(-10) M) for 30 min. After collection of the media, the MBHs were incubated with KRB containing high potassium (high K+ = 56 mM) without IL-2 for a period of 30 min to study the effect of pretreatment with IL-2 on depolarization-induced somatostatin and GRH release. Experiments were also undertaken to study the effect of IL-2 in the presence of high K+ or IL-2 in the presence of DA (60 microM), a potent stimulator of somatostatin and GRH release. The minimal effective dose of IL-2 which significantly stimulated the release of somatostatin was 10(-14) M. Depolarization-induced release of somatostatin was reduced significantly by prior treatment with all the concentrations of IL-2 tested (10(-13)-10(-10) M).(ABSTRACT TRUNCATED AT 250 WORDS)
MicroRNAs Play an Essential Role in the Development of Cardiac Hypertrophy (2007)

MicroRNAs are naturally existing, small, noncoding RNA molecules that downregulate posttranscriptional gene expression. Their expression pattern and function in the heart remain unknown. Here we report an array of microRNAs that are differentially and temporally regulated during cardiac hypertrophy. Significantly, the muscle-specific microRNA-1 (miR-1) was singularly downregulated as early as day 1 (0.56+/-0.036), persisting through day 7 (0.29+/-0.14), after aortic constriction-induced hypertrophy in a mouse model. Overexpression experiments showed that miR-1 inhibited its in silico-predicted, growth-related targets, including Ras GTPase-activating protein (RasGAP), cyclin-dependent kinase 9 (Cdk9), fibronectin, and Ras homolog enriched in brain (Rheb), in addition to protein synthesis and cell size. Thus, we propose that microRNAs play an essential regulatory role in the development of cardiac hypertrophy, wherein downregulation of miR-1 is necessary for the relief of growth-related target genes from its repressive influence and induction of hypertrophy.
Dual stream low complexity BICM reception and MIMO broadcast strategy (2008)

In this paper we consider channel coding for dual data streams with unequal error protection (UEP) for the objectives of low complexity receiver structures and prioritized handling of data in MIMO broadcast systems. We focus on high spectral efficiency bit interleaved coded modulation (BICM) MIMO OFDM system where two independently coded spatial streams of symbols are simultaneously transmitted by an antenna array using antenna cycling. In some sense, the receiver then views a multiple access channel (MAC) and consequently the reception is based on successive interference cancellation (SIC). The limited adaptability of the proposed system helps gear up to a higher data rate as channel conditions improve without any adjustment at the transmitter. This leads to devising a broadcast strategy incorporating different levels of service. Standard receiver solutions for such schemes employ sub-optimal linear minimum mean square error (MMSE) successive stripping decoders. We propose a novel low complexity near optimal demodulator based on match filter outputs for a dual stream system which exhibits better performance and lower complexity as that of MMSE based demodulator.
Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress (2023)

Abstract RNase R is a highly processive, 3’ -5’ exoribonuclease involved in RNA degradation, maturation, and processing in bacteria. In Pseudomonas syringae Lz4W, RNase R interacts with RNase E to form the RNA degradosome complex and is essential for growth at low temperature. RNase R is also implicated in general stress response in many bacteria. We show here that the deletion mutant of rnr gene (encoding RNase R) of P. syringae is highly sensitive to various DNA damaging agents and oxidative stress. RNase R is a multidomain protein comprised of CSD, RNB and S1 domains. We investigated the role of each domain of RNase R and its exoribonuclease activity in nucleic acid damage and oxidative stress response. Our results revealed that the RNB domain alone without its exoribonuclease activity is sufficient to protect against DNA damage and oxidative stress. We also show that the association of RNase R with the degradosome complex is not required for this function. Our study has discovered for the first time a hitherto unknown role of RNase R in protecting P. syringae Lz4W against DNA damage and oxidative stress. Importance Bacterial exoribonucleases play a crucial role in RNA maturation, degradation, quality control and turnover. In this study, we have uncovered a previously unknown role of 3’-5’ exoribonuclease RNase R of P. syringae Lz4W in DNA damage and oxidative stress response. Here, we show that neither the exoribonuclease function of RNase R, nor its association with the RNA degradosome complex is essential for this function. Interestingly, in P. syringae Lz4W, hydrolytic RNase R exhibits physiological roles similar to phosphorolytic 3’-5’ exoribonuclease PNPase of E. coli . Our data suggest that during the course of evolution, mesophilic E. coli and psychrotrophic P. syringae have apparently swapped these exoribonucleases to adapt to their respective environmental growth conditions.
Intrinsic origin of spin echoes in dipolar solids generated by strongπpulses (2008)

In spectroscopy, it is conventional to treat pulses much stronger than the linewidth as delta functions. In NMR, this assumption leads to the prediction that $\ensuremath{\pi}$ pulses do not refocus the dipolar coupling. However, NMR spin echo measurements in dipolar solids defy these conventional expectations when more than one $\ensuremath{\pi}$ pulse is used. Observed effects include a long tail in the CPMG echo train for short delays between $\ensuremath{\pi}$ pulses, an even-odd asymmetry in the echo amplitudes for long delays, an unusual fingerprint pattern for intermediate delays, and a strong sensitivity to $\ensuremath{\pi}$-pulse phase. Experiments that set limits on possible extrinsic causes for the phenomena are reported. We find that the action of the system's internal Hamiltonian during any real pulse is sufficient to cause the effects. Exact numerical calculations, combined with average Hamiltonian theory, identify terms that are sensitive to parameters such as pulse phase, dipolar coupling, and system size. Visualization of the entire density matrix shows a unique flow of quantum coherence from nonobservable to observable channels when applying repeated $\ensuremath{\pi}$ pulses.
Purification and application of a single-chain Fv antibody fragment specific to hepatitis B virus surface antigen. (1995)

Immobilized metal affinity chromatography (IMAC) has been recently applied to the purification of of recombinant proteins bearing multi-histidine domains at their N or C terminus. We have now used this procedure for the single-step purification of an anti-Hepatitis B virus surface antigen (HBsAg) single-chain Fv (scFv) antibody fragment. Adjusting the metal ion (Cu+2 or Ni+2) and elution conditions (pH or imidazole), we efficiently separated active scFv forms from inactive molecules. Achieved purity was 93%, with a 20% yield with respect to the scFv content in the initial material. The pure scFv was coupled to CNBr-activated Sepharose 4B and compared the original monoclonal antibody (MAb) CB-Hep.1 in the immunoaffinity purification of a vaccine recombinant HBsAg (r-HBsAg). Results indicate that eluted antigen per mg of coupled ligand was similar for the scFv and the MAb when pure r-HBsAg was used as starting material. Preliminary results with unpurified starting material are also encouraging.
5G Transport Slice Connectivity Interface (2019)

The 5G Network slicing is an approach to provide separate independent
E2E logical network from user equipment (UE) to applications where
each network slice has different SLA requirements. Each E2E network
slice consists of multitude of RAN-slice, Core-slice and Transport-
slices, each with its own controller. To provide automation, assurance
and optimization of the network slices, an E2E network slice
controller is needed which interacts with controller in RAN, Core and
Transport slices. The interfaces between the E2E network slice
controller and RAN and Core controllers are defined in various 3GPP
technical specifications. However, 3GPP has not defined the same
interface for transport slices. The aim of this document is to
provide the clarification of this interface and to provide the
information model of this interface for automation, monitoring and
optimization of the transport slices.
IT ATA ACQUISITION FOR A LARGE RQOP-MOUNTED PHOTOVOLTAIC ARRAY (1997)

1 2 Abstract - This paper describes a data acquisition system @AS) used to monitor the large photovoltaic system mounted on the roof of the Georgia Tech Aquatic Center. An example of the data collected from the DAS is given in an example monthly report of the system's performance. This report also describes a diagnostic application of this data, INTRODUCTION: THE GEORGIA TECH AQUATIC CENTER PV SYSTEM
Consistency Models with Global Operation Sequencing and their Composition (2017)

Linearizability is the commonly accepted notion of correctness for concurrent data structures. It requires that any execution of the data structure is justified by a linearization --- a linear order on operations satisfying the data structure's sequential specification. Proving linearizability is often challenging because an operation's position in the linearization order may depend on future operations. This makes it very difficult to incrementally construct the linearization in a proof. We propose a new proof method that can handle data structures with such future-dependent linearizations. Our key idea is to incrementally construct not a single linear order of operations, but a partial order that describes multiple linearizations satisfying the sequential specification. This allows decisions about the ordering of operations to be delayed, mirroring the behaviour of data structure implementations. We formalise our method as a program logic based on rely-guarantee reasoning, and demonstrate its effectiveness by verifying several challenging data structures: the Herlihy-Wing queue, the TS queue and the Optimistic set.
Automatic Virtual Metrology and Target Value Adjustment for Mass Customization (2016)

One of the core values of Industry 4.0 targets to integrate people's demand into manufacturing for enhanced products, systems, and services for a wider variety of increasingly personalized customization of products. Thus, Industry 4.0 advances the traditional manufacturing techniques from mass production toward mass customization (MC). Take wheel machining automation (WMA) as an example. To meet MC expectations, manufacturers should offer customized wheels at a large scale with low cost, short lead-time, and high quality. Thus, WMA cells with MC capability are requested to be designed to have a high degree of quick responsiveness to accurately react on machining-condition changes for manufacturing different wheel types. To meet the requirements of MC production, this work proposes to apply the automatic virtual metrology (AVM) system together with the so-called target-value-adjustment (TVA) scheme. The AVM system was developed by the authors to convert sampling inspections with metrology delay into real-time and on-line total inspection, while the TVA scheme is designed to enhance AVM's adaptive customization capability for automatically and rapidly accomplishing the goals of MC production. To demonstrate the versatility of the AVM-plus-TVA approach, the other example in semiconductor etching process is also illustrated.
ChemInform Abstract: CHEMICAL TRANSFORMATIONS OF DIANIONS OF TETRANITROETHANE AND 1,1,4,4‐TETRANITRO‐2,3‐BUTANEDIOL (1981)

Abstract Bei der Reaktion des Di‐K‐Salzes (I) mit wäßrigem Formalin entsteht, wahrscheinlich durch Zerfall des zunächst gebildeten Diols (II) und erneute Reaktionen mit Formaldehyd, ausschließlich das Dinitrodiol (III).
Emergence of highly designable protein‐backbone conformations in an off‐lattice model (2002)

Despite the variety of protein sizes, shapes, and backbone configurations found in nature, the design of novel protein folds remains an open problem. Within simple lattice models it has been shown that all structures are not equally suitable for design. Rather, certain structures are distinguished by unusually high designability: the number of amino acid sequences for which they represent the unique lowest energy state; sequences associated with such structures possess both robustness to mutation and thermodynamic stability. Here we report that highly designable backbone conformations also emerge in a realistic off-lattice model. The highly designable conformations of a chain of 23 amino acids are identified and found to be remarkably insensitive to model parameters. Although some of these conformations correspond closely to known natural protein folds, such as the zinc finger and the helix-turn-helix motifs, others do not resemble known folds and may be candidates for novel fold design.
P01.032 Associations of anticoagulant use with outcome in newly diagnosed glioblastoma (2018)

To test the hypothesis that, despite bleeding risk, anticoagulants improve outcome in glioblastoma because of reduced incidence of venous thromboembolic events and modulation of angiogenesis, infiltration and invasion. We assessed survival associations of anticoagulant use from baseline up to start of temozolomide chemoradiotherapy (TMZ/RT) (period I) and from there to the start of maintenance TMZ chemotherapy (period II) by pooling data of three randomized clinical trials in newly diagnosed glioblastoma including 1,273 patients. Progression-free survival (PFS) and overall survival (OS) were compared between patients with: anticoagulant use versus no use; therapeutic versus prophylactic versus no use; different durations of anticoagulant use versus no use; anticoagulant use versus use of anti-platelet agents, versus neither nor. Cox regression models were stratified by trial and adjusted for baseline prognostic factors. Anticoagulant use was documented in 75 patients (5.9%) in period I and in 104 patients (10.2%) in period II. Anticoagulant use during period II, but not period I, was associated with inferior OS compared to no use on multivariate analysis (p=0.001, HR=1.52, 95% CI: 1.18–1.95). No decrease in OS became apparent when only patients with prophylactic anticoagulant use were considered. No survival association was established for anti-platelet agent use. Anticoagulant use was not associated with improved OS. Anticoagulants may not exert relevant anti-tumor properties in glioblastoma.
기반 기술 : 오픈 소스 하드웨어를 이용한 임베디드 기반의 분산형 RFID 게이트웨이의 설계 (2015)

본 논문에서는 최근 이슈가 되고 있는 대표적인 오픈소스 하드웨어인 아두이노와 라즈베리파이를 이용하여 RFID (RadioFrequency IDentification) 게이트웨이를 구성한다. RFID 기술은 라디오 주파수 신호를 이용하여 자동으로 사물을 식별하는 기술로써 다양한 환경에 핵심 기술로 부각되고 있다. 본 논문에서는 다양한 리더의 통신 방법과 대량으로 발생하는 RFID 태그 정보를 효율적으로 처리하기 위한 분산형 RFID 게이트웨이를 제안하고, RFID 리더의 확장성과 미들웨어 통신 효율성을 높이고자 한다. 기존 RFID 미들웨어는 리더와 연동을 위한 웹 서비스 또는 표준 통신 규격을 준수해야하는 문제점이 존재한다. 따라서, 본 논문에서는 RFID 리더 제작 시 시리얼 통신 이외에 다양한 방식의 디지털 신호처리 방식의 통신 규격을 만족하도록 구성하여 미들웨어의 통신효율을 증대시킨다.
Separation, Immobilization, and Biocatalytic Utilization of Proteins by a Supramolecular Membrane (2013)

Membrane separation of biomolecules and their application in biocatalysis is becoming increasingly important for biotechnology, demanding the development of new biocompatible materials with novel properties. In the present study, an entirely noncovalent water-based material is used as a membrane for size-selective separation, immobilization, and biocatalytic utilization of proteins. The membrane shows stable performance under physiological conditions, allowing filtration of protein mixtures with a 150 kDa molecular weight cutoff (∼8 nm hydrodynamic diameter cutoff). Due to the biocompatibility of the membrane, filtered proteins stay functionally active and retained proteins can be partially recovered. Upon filtration, large enzymes become immobilized within the membrane. They exhibit stable activity when subjected to a constant flux of substrates for prolonged periods of time, which can be used to carry out heterogeneous biocatalysis. The noncovalent membrane material can be easily disassembled, purified, reassembled, and reused, showing reproducible performance after recycling. The robustness, recyclability, versatility, and biocompatibility of the supramolecular membrane may open new avenues for manipulating biological systems.
Characterizing Plasma Jet of HIIPER (2022)

View Video Presentation: https://doi.org/10.2514/6.2022-4272.vid Helicon Injected Inertial Plasma Electrostatic Rocket (HIIPER) is a combination of a radio-frequency (rf) thruster and an electrostatic propulsion system. Its design is inspired by a cold plasma, aneutronic, nuclear fusion device involving helicon plasma injection inside an Inertial Electrostatic Confinement (IEC) fusion reactor. Operating the IEC in the “Halo” (or “jet”) mode enables a unidirectional plasma jet that can be used to propel a space vehicle. Multiple researchers have independently observed the exhaust jet through experiments and theorized explanation based on their results, but a conclusive explanation of the physics involved is yet to be accepted. An experimental study was conducted to diagnose the properties of the exhaust jet and characterize its nature. It was found that the visible jet from the IEC cathode grid contained ions that can be used for space propulsion. The maximum beam current density of the exhaust jet was measured to be 1.273 A/(m^2). It is expected that the actual beam current density will be much higher when the experiments are repeated with higher (more negative) electron repeller potentials. Contrary to the electron temperature of 100’s of eV in the core, the jet electron temperature remained less than 10 eV for all the studied cases. The measured exhaust velocity of the ion jet remained between 24 km/s and 55 km/s for various operating conditions. These exit velocities classify HIIPER as a high specific impulse propulsion system. A novel, plasma plume diagnostic technique using solid state nuclear track detector is also described in the paper.
Impact of phosphorylation on the encapsulation of nucleoside analogues within porous iron(iii) metal–organic framework MIL-100(Fe) nanoparticles (2013)

Encapsulation of azidothymidine (AZT) or its phosphorylated derivatives (AZT-MP and AZT-TP) has been performed using nanoparticles of the porous crystalline iron(iii) trimesate metal-organic framework MIL-100(Fe). The number of phosphate groups per nucleoside analogue has a high impact on the drug loading capacity, and their interaction with the Lewis acid sites from the nanoMOFs is also discussed through a combination of techniques such as UV-vis absorption, circular dichroism, isothermal titration calorimetry, HPLC and molecular simulations. Finally, the effect of the differences in terms of host-guest interactions is discussed through the release in physiological buffers of AZT, AZT-MP and AZT-TP. New perspectives for the nanoencapsulation of monophosphorylated nucleoside analogues for effective anti-cancer and anti-viral therapies are then discussed.