gebhart/patrepeval huggingface dataset:
Presence of H-Y Antigen and Testis in 46, XX True Hermaphroditism, Evidence for Y-Chromosomal Function (1976)

Endocrinologic and serologic studies of a 2-year-old child with the chromosomal complement 46,XX and ambiguous genitalia suggested the preoperative diagnosis of true hennaphroditism. Urinary and serum androgen production in response to human chorionic gonadotrophin was in the range expected for normal males, implying presence of cryptic testicular tissue. Moreover, detection of H-Y antigen, a cell surface component associated with testicular differentiation and coded or regulated by a Y-chromosomal gene, indicated presence of Y-chromosomal material. The diagnosis of true hennaphroditism was confirmed at surgery. Assuming a constant association of H-Y antigen and testicular differentiation is established, human H-Y serology may be an important adjunct to the endocrinologic evaluation of intersex patients. Our studies support the interpretation that a Y-chromosomal translocation too small for cytologic detection accounts for testicular differentiation in 46, XX true hennaphroditism. Expression of H-Y antigen remained positive after castration.
POSS nanocrosslinked poly (ethylene glycol) hydrogel as hybrid material support for silver nanocatalyst (2018)

Silver nanoparticles supported on polyhedral oligomeric silsesquioxane (OA‐POSS) nanocrosslinked poly (ethylene glycol)‐based hydrogels (PEG 600 ‐POSS/Ag NPs) as novel nanohybrid catalysts were synthesized for the first time. The as‐prepared nanohybrid hydrogels were fully characterized by FT‐IR, SEM, EDX, XRD, TEM and TGA. PEG 600 ‐POSS/Ag NPs exhibited excellent catalytic performance for the reduction of 4‐nitrophenol (4‐NP) to 4‐aminophenol (4‐AP) in water at room temperature in the presence of borohydride.
Supplementary Figure Legend and Table 1 from MCT-1 Protein Interacts with the Cap Complex and Modulates Messenger RNA Translational Profiles (2023)

Supplementary Figure Legend and Table 1 from MCT-1 Protein Interacts with the Cap Complex and Modulates Messenger RNA Translational Profiles
Fast object detection based on binary deep convolution neural networks (2018)

In this study, a fast object detection algorithm based on binary deep convolution neural networks (CNNs) is proposed. Convolution kernels of different sizes are used to predict classes and bounding boxes of multi‐scale objects directly in the last feature map of a deep CNN. In this way, rapid object detection with acceptable precision loss is achieved. In addition, binary quantisation for weight values and input data of each layer is used to squeeze the networks for faster object detection. Compared to full‐precision convolution, the proposed binary deep CNNs for object detection results in 62 times faster convolutional operations and 32 times memory saving in theory, what's more, the proposed method is easy to be implemented in embedded computing systems because of the binary operation for convolution and low memory requirement. Experimental results on Pascal VOC2007 validate the effectiveness of the authors’ proposed method.
Antifungal Activity of 4-Methyl-6-alkyl-2H-pyran-2-ones (2006)

A number of 4-methyl-6-alkyl-alpha-pyrones were synthesized and characterized on the basis of 1H NMR and mass spectroscopy. These compounds were tested in vitro against pathogenic fungi, namely, Sclerotium rolfsii Saccardo, Rhizoctonia bataticola (Taub.) Butler, Pythium aphanidermatum (Edson) Fitz., Macrophomina phaseolina (Tassi), Pythium debaryanum (Hesse), and Rhizoctonia solani Nees. Lower homologues were less effective, whereas compounds such as 4-methyl-6-butyl-alpha-pyrone, 4-methyl-6-pentyl-alpha-pyrone, 4-methyl-6-hexyl-alpha-pyrone, and 4-methyl-6-heptyl-alpha-pyrone were found effective against all of the test fungi. They inhibited mycelial growth by approximately 50% (ED50) at 15-50 microg/mL. 4-Methyl-6-hexyl-alpha-pyrone, which was found most effective, was tested against S. rolfsii in a greenhouse at 1, 5, and 10% concentrations. The 10% aqueous emulsion of 4-methyl-6-hexyl-alpha-pyrone suppressed disease development in tomato by 90-93% as compared with the untreated infested soil in the greenhouse after 35 days of treatment.
Effects of the Amount of &gamma;' Phase on the Creep Strength of the Dispersion Strengthened Ni-base Superalloys (1989)

Effect of the amount of γ' phase was studied on the creep strength of an oxide dispersion strengthened nickel-base superalloy TMO-2, and its related alloys in which the γ' content was varied from 35 to 75 %. At middle or low temperature (1 075 to 1 223 K), both the creep resistance and the rupture life increased with increasing the amount of the γ', phase. This is due to the fact that the creep deformation in this temperature range is accompanied by the shear of the γ' particles precipitated in the γ' phase. At high temperature (1 323 K), neither the creep resistance nor the rupture life depended on the amount of the γ' phase. The creep deformation at this temperature is related to the growth of voids or cracks generated at around needle-like carbides precipitated upon creep testing. Creep rupture elongations were very small (14%) in all test condions, and independent of the amount of the γ' phase. At temperatures below 1 233K, DOBES-MILICKA's relation holds among the rupture elongations, rupture lives and the steady state creep rates.
[DPPH radical scavenging activities of 31 flavonoids and phenolic acids and 10 extracts of Chinese materia medica]. (2009)

The DPPH radical scavenging activities of the 31 compounds were founded to be related to their chemical structures, such as the number and position of hydroxyl groups. And a qualitative relationship was found between DPPH radical scavenging activities and E1/2 values of the 31 compounds, the lower the E1/2 values, the higher the DPPH radical scavenging activities. A quantitative relationship was obtained to describe the DPPH radical scavenging activity of the herb extracts: Y = 7.779X(-0.48), r = 0.929 5, where Y stands for the concentration for 50% inhibition of DPPH radical, and X stands for the concentration of total phenolic compaunds, namely the extracts with higher content of flavonoids and phenolic acid exhibited the stronger DPPH radical scavenging activity.
Use of [18F]Fluorodeoxyglucose Positron Emission Tomography in Evaluating Locally Recurrent and Metastatic Adrenocortical Carcinoma (2006)

Most adrenocortical carcinomas accumulate and retain FDG and thus can be visualized by PET. However, false-negative findings are possible, especially with very small lesions.
MATHICSE Technical Report: Controlling oscillations in high-order Discontinuous Galerkin schemes using artificial\ viscosity tuned by neural networks (2019)

High-order numerical solvers for conservation laws suer from Gibbs phenomenon close to discontinuities, leading to spurious oscillations and a detrimental effect on the solution accuracy. A possible strategy to reduce it comprises adding a suitable amount of artificial dissipation. Although several viscosity models have been proposed in the literature, their dependence on problem-dependent parameters often limits their performances. Motivated by the objective to construct a universal artificial viscosity method, we propose a new technique based on neural networks, integrated into a Runge-Kutta Discontinuous Galerkin solver. Numerical results are presented to demonstrate the performance of this network-based technique. We show that it is able both to guarantee optimal accuracy for smooth problems, and to accurately detect discontinuities, where dissipation has to be injected. A comparison with some classical models is carried out, showing the superior performance of the network-based model in capturing both complex and fine structures.
Identification of a Novel Protein with a Role in Lipoarabinomannan Biosynthesis in Mycobacteria (2006)

All species of Mycobacteria synthesize distinctive cell walls that are rich in phosphatidylinositol mannosides (PIMs), lipomannan (LM), and lipoarabinomannan (LAM). PIM glycolipids, having 2-4 mannose residues, can either be channeled into polar PIM species (with 6 Man residues) or hypermannosylated to form LM and LAM. In this study, we have identified a Mycobacterium smegmatis gene, termed lpqW, that is required for the conversion of PIMs to LAM and is highly conserved in all mycobacteria. A transposon mutant, Myco481, containing an insertion near the 3' end of lpqW exhibited altered colony morphology on complex agar medium. This mutant was unstable and was consistently overgrown by a second mutant, represented by Myco481.1, that had normal growth and colony characteristics. Biochemical analysis and metabolic labeling studies showed that Myco481 synthesized the complete spectrum of apolar and polar PIMs but was unable to make LAM. LAM biosynthesis was restored to near wild type levels in Myco481.1. However, this mutant was unable to synthesize the major polar PIM (AcPIM6) and accumulated a smaller intermediate, AcPIM4. Targeted disruption of the lpqW gene and complementation of the initial Myco481 mutant with the wild type gene confirmed that the phenotype of this mutant was due to loss of LpqW. These studies suggest that LpqW has a role in regulating the flux of early PIM intermediates into polar PIM or LAM biosynthesis. They also suggest that AcPIM4 is the likely branch point intermediate in polar PIM and LAM biosynthesis.
Convulsive status epilepticus in children in Mozambique: Is there a treatment gap? (2021)

Background: Optimal care of Convulsive status epilepticus (CSE) can be related to multiple barriers in resource-limited countries. Objectives and methods: Since limited data of CSE management are available from South-East Africa, we performed a retrospective analysis of the electronic records of pediatric patients with CSE admitted to the Maputo Central hospital from January 2016 until April 2019. Results: Our database consisted out of 39 patients. The average age was 5.15 (range 0.3-13.8) years and demographic characteristics did not show a relation to CSE characteristics or outcomes. However, the total stay in the hospital was negatively correlated with age (p=0.0314). Moreover, 14 patients needed to be admitted to the IC, which was correlated to having generalized motor seizures (p=0.0253), and a relatively higher need for a second AED to control their CSE (p=0.0131). Regarding AED use, the first AED was a IV benzodiazepine (BZD: midazolam (MIDA) or diazepam (DIAZ)) or IV phenytoin (PHEN) when BZDs were not available. There was no statistically significant difference between the efficacy of MIDA vs. DIAZ. Eleven patients received PHEN as a second-line drug, of which only two patients needed an additional dose of PHEN. None of the patients died and five patients (13.2%) had an extra comorbidity after CSE. Conclusions: Although limited AEDs were available in our study, compared to more AEDs in other developing and developed countries, we report the successful cessation of CSE in the majority of cases. We recommend strategies to improve prehospital management such as the use of non-IV BZD use, to limit the need for patients to be admitted to the IC and thereby potentially decreasing the number of AEDs, morbidity and hospital duration. Moreover, our data underline the conversion to second-line AEDs (PHEN) to be adequate in nearly all patients.
Initial clinical experience with the picosecond Nd:YLF laser for intraocular therapeutic applications (1998)

Series of ps pulses applied in computer controlled patterns can be used effectively for laser surgery in the anterior segment and are considerably less disruptive than ns pulses. The ps laser is well suited for laser iridectomies while the ns laser is preferable for posterior capsulotomies. As vitreoretinal applications remained unsuccessful, the range of indications for intraocular photodisruption could not be extended by the ps laser.
A Three-Dimensional Deterministic Model for Rough Surface Line-Contact EHL Problems (2007)

This paper reports the development of a novel three-dimensional (3D) deterministic model for rough surface line-contact mixed-EHL problems. This model is of great importance because line contacts are found in many mechanical components. The macro aspects of a line-contact problem can be simplified into a two-dimensional (2D) model, but the topography of contacting rough surfaces, micro asperity contacts, and lubricant flows around asperities are often 3D. The present model is based on Hu and Zhu’s unified mixed EHL model [1] and the mixed FFT-based approach formulated by Chen et al [2]. It is numerically verified through comparisons with results from conventional 2D line-contact EHL theories. Numerical examples involving sinusoidal roughness and digitized 3D machined surfaces are analyzed.
Effect of Intravenous Intraoperative Esmolol on Pain Management Following Lower Limb Orthopedic Surgery (2015)

Intravenous intraoperative esmolol is effective in the reduction of postoperative pain following leg fracture surgery. It reduced opioid consumption following surgery and delayed patient requests for analgesics.
Electrostatically charged COVID-19 disinfectant spray coverage on a cylinder (2021)

Surface disinfecting has become a necessity in the global effort to control the COVID-19 pandemic, and the application of disinfectant liquid to completely and uniformly cover target objects is a common goal. Spraying of these materials offers a clearly beneficial solution where the liquid is atomized into droplets which are distributed on the target surface. However, while surfaces in the direct line-of-sight may receive adequate coverage, hidden surfaces on the side and back of an object may be shielded and receive limited or no coating. Electrostatically charged sprays have received added attention and use because, in concept, a charged droplet may be more likely to not only land on a surface through direct impingement, but also be drawn further toward hidden surfaces due to attractive charge forces. Therefore, electrostatically charged sprayers provide a uniquely beneficial method to distribute disinfectant materials, although the actual effects have received limited scientific analysis. In the present study, a commercially available electrostatic sprayer has been investigated with electrostatic spray charge off and on in order to evaluate the resulting coating completeness, uniformity, and efficiency. Measurements of the spray drop size distribution upstream of the target cylinder offer insight for differences in the resulting coverage. While this investigation is not comprehensive, it serves to offer insight into the potential benefits of electrostatically charged disinfecting sprays as well as explanations into how those improvements are achieved. Using the present sprayer, disinfectant material, and target object, coverage was improved by 40% using charged droplets which was primarily due to increased coverage on the downstream (back) side of the target cylinder, which saw zero coverage without charged droplets.
Acoustical holography in spherical coordinates for noise source identification (1994)

Acoustical holography has been applied most often to visualize the sound field of planar sources driven by known forces. In this paper the application of acoustical holography to machinery noise source identification, when it is possible to enclose the source entirely by a spherical measurement surface, is considered. That procedure amounts to representing the sound field on the measurement surface as a summation of spherical harmonics, each of which is associated with a particular spherical Hankel function. Once the spherical harmonics have been identified, each may be propagated inward towards the source for the purpose of source identification, or outward to visualize the sound field. The combination of those procedures with the use of multiple reference microphones to visualize the sound field radiated by multiple incoherent sub-sources will also be described. The procedures will first be illustrated by visualizing the sound field radiated by several simple sources (i.e., monopoles and dipoles) when operated either individually or in combination. Next, the vibration of a refrigeration compressor shell is visualized, both when mechanically driven at a single interior point and by internal pressure pulsations. Finally, results for a compressor in normal operation will be shown.
Insights into the Electrochemical Behavior of Manganese Oxides as Catalysts for the Oxygen Reduction and Evolution Reactions: Monometallic Core‐Shell Mn/Mn3O4 (2023)

Overcoming the sluggish electrode kinetics of both oxygen reduction and evolution reactions (ORR/OER) with non-precious metal electrocatalysts will accelerate the development of rechargeable metal-air batteries and regenerative fuel cells. The authors investigated the electrochemical behavior and ORR/OER catalytic activity of core-porous shell Mn/Mn<sub>3</sub> O<sub>4</sub> nanoparticles in comparison with other manganese dioxides (β- and γ-MnO<sub>2</sub> ), and benchmarked against Pt/C and Pt/C-IrO<sub>2</sub> . Under reversible operation in O<sub>2</sub> -saturated 5 M KOH at 22 °C, the early stage activity of core-shell Mn/Mn<sub>3</sub> O<sub>4</sub> shows two times higher ORR and OER current density compared to the other MnO<sub>2</sub> structures at 0.32 and 1.62 V versus RHE, respectively. It is revealed that Mn(III) oxidation to Mn(IV) is the primary cause of Mn/Mn<sub>3</sub> O<sub>4</sub> activity loss during ORR/OER potential cycling. To address it, an electrochemical activation method using Co(II) is proposed. By incorporating Co(II) into MnO<sub>x</sub> , new active sites are introduced and the content of Mn(II) is increased, which can stabilize the Mn(III) sites through comproportionation with Mn(IV). The Co-incorporated Mn/Mn<sub>3</sub> O<sub>4</sub> has superior activity and durability. Furthermore, it also surpassed the activity of Pt/C-IrO<sub>2</sub> with similar durability. This study demonstrates that cost-effective ORR/OER catalysis is possible.
Effect of sexual maturation on muscle gene expression of rainbow trout: RNA-Seq approach (2013)

Muscle degradation occurs as a response to various physiological states that are regulated by specific molecular mechanisms. Previously, we characterized the metabolic changes of muscle deterioration of the female rainbow trout at full sexual maturity and spawning (Salem et al., Physiol. Genomics 2006;28:33-45; J. Proteomics 2010;73:778-789). Muscle deterioration in this model represents nutrient mobilization as a response to the energetic overdemands of the egg/ovarian growth phase. Our recent studies showed that most of the changes in muscle growth and quality start 2-3 months before spawning. Gravid fish exhibited reduced intramuscular fat that is lower in saturated and monounsaturated fatty acids and higher in polyunsaturated fatty acids compared to sterile fish. In this study, RNA-Seq was used to explain the mechanisms underlying changes during this phase of sexual maturity. Furthermore, to minimize changes due to nutrient deficits, fish were fed on a high-plane of nutrition. The RNA-Seq technique identified a gene expression signature that is consistent with metabolic changes of gravid fish. Gravid fish exhibited increased abundance of transcripts in metabolic pathways of fatty acid degradation and up-regulated expression of genes involved in biosynthesis of unsaturated fatty acids. In addition, increased expression of genes involved in the citric acid cycle and oxidative phosphorylation was observed for gravid fish. This muscle transcriptomic signature of fish fed on a high nutritional plane is quite distinct from that previously described for fish at terminal stages of maturity and suggest that female rainbow trout approaching spawning, on high nutritional planes, likely mobilize intramuscular fat rather than protein to support gonadal maturation.
ChemInform Abstract: Preparation of New Nitrogen‐Bridged Heterocycles. Part 18. Facile Formations of 3‐Arylpyrazolo(1,5‐a)pyridines and 1‐Arylindolizines. (1988)

Abstract 20 Derivatives of type (IV) and 24 of type (VI)/(VIII) are prepared by S‐benzylation of pyridinium N‐ylides (I), (V), (VII), followed by base‐catalyzed ring closure via an intermediate of type (III) in the presence or absence of a dehydrogenating agent.
FeCl2 Catalyzed Three-Component Reactions of Phospholes, Pyrrolidine, and Ketones (Aldehydes): Chemoselective Synthesis of 1-Phosphafulvenes (2021)

We have developed an unprecedented approach for the synthesis of transient 1-phosphafulvenes through three component reactions of phospholes. The generation of 1-phosphafulvenes was demonstrated by in situ [6 + 4] cycloaddition with 2H-phospholes and [6 + 6] self-dimerization. The [6 + 4] and [6 + 6] reaction pathway could be modulated by the starting ketones and aldehydes. The construction of 1-phosphafulvenes is illustrated by a proposed mechanism combining nucleophilic addition of phospholide to the iminium or isomerized azomethine ylide and a [1,5]-shift of phosphole.
The application of Forth engines as coprocessors for the Macintosh computer (1991)

Article Free Access Share on The application of Forth engines as coprocessors for the Macintosh computer Authors: Albert Pierce Consultant/Programming Services Associates, 166 South J Street, Livermore, CA Consultant/Programming Services Associates, 166 South J Street, Livermore, CAView Profile , Elizabeth Pierce View Profile Authors Info & Claims FORTH '90 and '91: Proceedings of the second and third annual workshops on ForthMarch 1991 Pages 45–48https://doi.org/10.1145/259965.259994Published:07 March 1991Publication History 0citation168DownloadsMetricsTotal Citations0Total Downloads168Last 12 Months18Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Crack tip position evaluation and Paris’ law assessment of a propagating crack by means of temperature-based approaches (2022)

This paper investigates the possibility to evaluate the crack tip position, crack growth rate and stress intensity factor (SIF), in order to derive the Paris law by starting from the temperature distribution measured by means of an infrared camera, with high geometrical resolution. In more detail, constant amplitude, fully reversed, stress controlled, crack propagation fatigue tests were carried out on two single edge notch tension specimens machined from 4-mm-thick, hot-rolled AISI 304L stainless steel sheets. The temperature maps were then processed by using a signal reconstruction algorithm based on the least square method in order to extract the maps of the amplitude and phase signal components of the first and second harmonics. In particular, the amplitude maps of the thermoelastic signal allowed the estimation of the stress intensity factor (SIF) using well-established methods, while the thermoelastic phase and second harmonic phase maps were used for estimating the crack-tip position. As for the determination of the crack tip using the phase maps, an experimental approach based on the evaluation of the inversion point of a phase profile (parallel to the crack propagation direction ) was adopted. Such a point would represent the beginning of the reverse plasticity zone in the first and second harmonics phase maps. The crack tip position based on temperature maps was systematically compared to that measured by means of a digital microscope. Similarly, experimental SIF values derived from the thermoelastic signals were compared with the relevant numerical values from linear elastic FE analyses. The resulting Paris laws were critically compared. The good agreement between the preliminary data suggest further investigations regarding the applicability of these methods in all load conditions.