gebhart/patrepeval huggingface dataset:
Exogenous Ketone Supplements Improved Motor Performance in Preclinical Rodent Models (2020)

Nutritional ketosis has been proven effective for neurometabolic conditions and disorders linked to metabolic dysregulation. While inducing nutritional ketosis, ketogenic diet (KD) can improve motor performance in the context of certain disease states, but it is unknown whether exogenous ketone supplements-alternatives to KDs-may have similar effects. Therefore, we investigated the effect of ketone supplements on motor performance, using accelerating rotarod test and on postexercise blood glucose and <i>R</i>-beta-hydroxybutyrate (<i>R</i>-βHB) levels in rodent models with and without pathology. The effect of KD, butanediol (BD), ketone-ester (KE), ketone-salt (KS), and their combination (KE + KS: KEKS) or mixtures with medium chain triglyceride (MCT) (KE + MCT: KEMCT; KS + MCT: KSMCT) was tested in Sprague-Dawley (SPD) and WAG/Rij (WR) rats and in GLUT-1 Deficiency Syndrome (G1D) mice. Motor performance was enhanced by KEMCT acutely, KE and KS subchronically in SPD rats, by KEKS and KEMCT groups in WR rats, and by KE chronically in G1D mice. We demonstrated that exogenous ketone supplementation improved motor performance to various degrees in rodent models, while effectively elevated <i>R</i>-βHB and in some cases offsets postexercise blood glucose elevations. Our results suggest that improvement of motor performance varies depending on the strain of rodents, specific ketone formulation, age, and exposure frequency.
Prediction of dairy performance of cows by theinduced lactation (1962)

合計100万IU.のオイベスチン処理による誘起泌乳の成績について検討を加えた。福島種畜牧場,北海道農試畜産部,東大農学部牧場の3ヵ所24頭のホルスタイン及び同種系牛について泌乳,繁殖,発育状況を調べた。総平均で総乳量952.5kg,最高日量5.60kg,平均乳脂率3.35%であつた。福島と北海道との間に各形質とも差があり,福島で高かつた。遺伝的な要因と共に夫々の場所内で共通な環境要因の影響のあることが窺われた。泌乳諸形質間の相関を調べ,さらに半きようだいでの級内相関で表型似通いの程度を算出したが0.318~0.588でかなり高い値を得た。繁殖への影響は,強く出た場合も少数あつたが,大部分は憂うべきものとはいえない。発育への影響は軽微であつた。
Performance Analysis and Optimization of UAV Integrated Terrestrial Cellular Network (2018)

Unmanned aerial vehicles (UAVs) have been extensively applied as aerial access points to assist the terrestrial wireless network. Despite the inherent potential, nevertheless, it still remains to explore whether the gain of UAV access points (UAPs) could be fully harvested, which is critically dependent on the factors including the flight altitude and deployment density of UAPs. In this light, we investigate the performance of a downlink UAV integrated terrestrial cellular network (UTCN) and analytically study the influence of varying UAP altitude and density on the spatial throughput (ST) of UTCN. In particular, we obtain the UAP altitude upper bound, below which more line-of-sight (LOS) connections could be provided to improve network ST. Otherwise, cross-layer interference over the LOS paths becomes dominant, which results in significant degradation of network ST. More importantly, we reveal the limitation of the application of UAPs by showing that there exists a critical UAP density, beyond which network ST would encounter a rapid decrease. To fully exploit the potential of UAPs, we further tailor a probabilistic interference avoidance scheme and study the optimization of the UAP activated probability. Remarkably, network ST could be substantially improved using the optimized activated probability, i.e., network ST could increase with the growing UAP density and converge to a positive constant instead of zero in the dense UAP regime. Therefore, the results of this paper could provide insight on the deployment and optimization of UTCN.
Recommendation algorithm based on user attributes and tag preferences (2020)

Abstract Aiming at the problem of sparse data and low recommendation accuracy of recommendation systems in a big data environment, a UT-CF algorithm that combines user attributes and tag preferences is proposed. The algorithm extracts and selects user attribute information, calculates the user attribute similarity matrix according to the user attribute characteristics; obtains the user’s tag score according to each score of the user item score matrix, obtains the user tag preference matrix, and calculates the difference between user tags Similarity, to get the user’s similar neighbors; In order to reduce the search space of similar users, the K-means clustering algorithm based on the principle of maximum distance is introduced. Make the top k recommendations based on the recommendations of the target user’s nearest neighbors. Through the experiment of MovieLens 100K data set, the algorithm improves the accuracy of recommendation.
Analysis and Design of Multistage Electrostatically-Actuated Micro Vacuum Pumps (2002)

A new concept for a MEMS-fabricated micro vacuum pump is proposed. The pump is designed to operate in air and can be easily integrated into MEMS-fabricated micro fluidic systems. The pump consists of a series of pumping cavities with electrostatically actuated membranes interconnected by electrostatically actuated microvalves. A thermodynamic model of the micropump has been developed and used to determine the pump performance. It is shown that volume ratio plays an important role in the operation of the pump. For a fixed number of stages, at high volume ratio, pumping action is uniformly distributed among the stages. In contrast, at low volume ratio most of the pumping takes place in the latter stages of the pump. Detailed calculations of the flow through key components of the micropump are also reported. In particular the flow through a checkerboard microvalve and electrode perforations is discussed, and new correlations for the pressure loss in these components are proposed.
<title>Components of variance in ROC analysis of CADx classifier performance</title> (1998)

We analyze the contributions to the population variance of the area under the ROC curve in assessment of CADx classifier performance and consider a number of models for this variance. The models all contain a pure term or terms in the number of training samples, a pure term in the number of test samples, plus a term or terms representing their interaction. The subset of terms containing the number of test samples also provide a model for what we call the mean Wilcoxon variance based on a single data set. By this variance we mean a nonparametric estimate of the uncertainty in the ROC area obtainable from a single experiment. The remaining terms--i.e., the pure terms in the number of training samples--are not directly estimable without drawing additional training samples. We investigate whether they may be inferred indirectly using a resampling strategy. The current study is presented within the context of our previous work on finite-sample effects on classifier performance, and is related to recent work of others on Analysis of Variance in ROC analysis.
Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A (2011)

We have generated 3 mouse lines, each with a different mutation in the nonmuscle myosin II-A gene, Myh9 (R702C, D1424N, and E1841K). Each line develops MYH9-related disease similar to that found in human patients. R702C mutant human cDNA fused with green fluorescent protein was introduced into the first coding exon of Myh9, and D1424N and E1841K mutations were introduced directly into the corresponding exons. Homozygous R702C mice die at embryonic day 10.5-11.5, whereas homozygous D1424N and E1841K mice are viable. All heterozygous and homozygous mutant mice show macrothrombocytopenia with prolonged bleeding times, a defect in clot retraction, and increased extramedullary megakaryocytes. Studies of cultured megakaryocytes and live-cell imaging of megakaryocytes in the BM show that heterozygous R702C megakaryocytes form fewer and shorter proplatelets with less branching and larger buds. The results indicate that disrupted proplatelet formation contributes to the macrothrombocytopenia in mice and most probably in humans. We also observed premature cataract formation, kidney abnormalities, including albuminuria, focal segmental glomerulosclerosis and progressive kidney disease, and mild hearing loss. Our results show that heterozygous mice with mutations in the myosin motor or filament-forming domain manifest similar hematologic, eye, and kidney phenotypes to humans with MYH9-related disease.
A raytracing method to create inhomogeneous wave fields for collaborative virtual reality systems (2018)

A new rapid, raytracing method was developed and implemented for collaborative virtual reality systems. The goal of the method was to auralize historic acoustic venues in Rensselaer’s Collaborative-Research Augmented Immersive Virtual Environment Laboratory (CRAIVE-Lab). The CRAIVE-Lab provides a physical/digital environment for collaborative tasks using seamless video from multiple projectors and a 128-channel wave-field system with 6 additional ceiling loudspeakers. For the raytracing method, scanned floor plans are marked up by the user to create a two-dimensional geometric room model to calculate the temporal and spatial early-reflection pattern for the horizontal array of 128 loudspeakers resulting in an individual impulse response for each of the 128 loudspeakers. For this purpose, the loudspeaker array is virtually placed within the floor plan to calculate the impulse responses at each loudspeaker position considering the angles of incidence. The user can define wall materials and a directivity pattern for each sound source. The late reverberation tail is generated using a stochastic model based on the volume and surface characteristics of the space. An individual exponentially decaying reverberation tail is computed for each of the 134 loudspeakers with frequency-specific decay times. [Work supported by NSF Grant Nos. #1229391 and CISL.]
High-Temperature Adhesives for Thermally Stable Aero-Assist Technologies (2013)

Aero-assist technologies are used to control the velocity of exploration vehicles (EVs) when entering Earth or other planetary atmospheres. Since entry of EVs in planetary atmospheres results in significant heating, thermally stable aero-assist technologies are required to avoid the high heating rates while maintaining low mass. Polymer adhesives are used in aero-assist structures because of the need for high flexibility and good bonding between layers of polymer films or fabrics. However, current polymer adhesives cannot withstand temperatures above 400 C. This innovation utilizes nanotechnology capabilities to address this need, leading to the development of high-temperature adhesives that exhibit high thermal conductivity in addition to increased thermal decomposition temperature. Enhanced thermal conductivity will help to dissipate heat quickly and effectively to avoid temperature rising to harmful levels. This, together with increased thermal decomposition temperature, will enable the adhesives to sustain transient high-temperature conditions.
Atomistic Underpinnings for Orientation Selection in Alloy Dendritic Growth (2007)

In dendritic solidification, growth morphologies often display a pronounced sensitivity to small changes in composition. To gain insight into the origins of this phenomenon, we undertake an atomistic calculation of the magnitude and anisotropy of the crystal-melt interfacial free energy in a model alloy system featuring no atomic size mismatch and relatively ideal solution thermodynamics. By comparing the results of these calculations with predictions from recent phase-field calculations, we demonstrate that alloying gives rise to changes in free-energy anisotropies that are substantial on the scale required to induce changes in growth orientations.
The Cr3+:Yb3+:Ln3+:YSGG crystals as solid- state laser materials (1994)

The concentration of Ln 3+ ions in gallium garnets doped by Cr 3+ ions must be high enough to efficiently transfer energy Cr 3+ →Ln 3+ . Low concentration of Ln 3+ ions in some cases presents interest because it allows to avoid the concentrational quenching of some Ln 3+ ion levels and to decrease the lasing threshold of three-level lasers.
Saproxylic beetle tolerance to habitat fragmentation induced by salvage logging in a boreal mixed‐cover burn (2012)

Abstract Saproxylic insect assemblages associated with burned forests are generally abundant and species rich, consisting of a mix of pyrophilous and secondary, opportunistic species depending on time elapsed since disturbance. Life‐history traits associated with each group suggest that they may respond differentially to habitat fragmentation caused by salvage logging, with pyrophilous species having a much higher dispersal potential. In a 2‐year‐old burn highly fragmented by pre‐ and post‐fire logging, we sampled saproxylic beetles in coniferous and broadleaf burned residual stands along a gradient of spatial context including intensity of fragmentation and isolation from source habitat using Lindgren multiple‐funnels traps. Beetle assemblages differed in composition between coniferous and broadleaf burned stands, with secondary users dominating the latter. Pyrophilous species increased in abundance with distance from the edge and avoided unburned patches within the fire. Secondary users did not respond negatively to fragmentation or isolation of burned habitats, with one exception, the alleculid I somira quadristriata (Couper), being overall diverse and abundant throughout the study area regardless of salvage logging prevalence. No deleterious effects of isolation were thus detected in the occurrence patterns of secondary users, even up to 8 km from the edge. Our results suggest that older burns, especially those having some broadleaf cover, are intensively used by non‐pyrophilous saproxylic species usually associated with dead wood in green forests and may contribute to maintain broader saproxylic assemblages than originally thought, especially when considering the importance of dead wood volume pulses associated with fire in boreal forests.
Synthesis of symmetric and non-symmetric indolo[2,3-c]carbazole derivatives: preparation of indolo[2,3-c]pyrrolo[3,4-a]carbazoles (1998)

Symmetric and non-symmetric indolo[2,3-c]carbazoles have been prepared from 3,3′-biindolyls 9a–d by two strategies; step by step, by thermal electrocyclic reaction, or directly. Indolo[2,3-c]pyrrolo[3,4-a]carbazoles 28aa–db, a new class of indolopyrrolocarbazoles, have been obtained in a one step reaction from readily available precursors.
Rubber Linings - Overview and New Technology (1995)

Abstract Rubber linings as used for corrosion and abrasion service have made strides in the area of adhesives, new products and vulcanization methods. Each one of these areas and some developments in Europe are covered in the paper.
Cardiovascular biomarkers in the ICU (2009)

Recent studies confirm the excellent prognostic value of natriuretic peptide measurements in ICU patients. Diagnostic properties of natriuretic peptide in ICU patients still remain ambiguous and require further evaluation. Systematic screening with cTn reveals more myocardial infarctions and provides important prognostic information.
Behind the TV Camera (1960)

Me, a television director? That was a far away pipe dream when I first stumbled upon the idea that I might like to make my career in the challenging medium of television.
CNES Miniaturization Policy: An Answer to Nanosatellites Challenges (2019)

The reduction of mass and size with improvement of the performance of a device is a permanent challenge for the space industry. The French National Space Agency has funded hundreds of R&D activities in the past, in all dedicated technical areas to facilitate these kind of technological evolution. Miniaturization efforts have, more recently, encountered a growing field of application, the one of Nanosatellites. For these applications, performance/cost trade-off is largely dominated by full cost, that is to say the cost including the entire satellite system development, from the initial idea to the end of life, including operations, data processing and its distribution. The carried out trade-offs are therefore based on a different constraints environment, in which the risk variable is systematically re-evaluated considering the cost/performance couple; the methods, the development process and the planning of delivery being directly impacted by this challenge. In this logic, and while continuing its efforts to miniaturize and improve performance for conventional markets (Earth observation, science, telecommunications, ...), CNES has adapted its working environment around the Nanosats domain to accelerate the development of adapted solutions. This adaptation being made both in terms of new development processes and of use of new COTS technology for equipment themselves. Moreover, projects in New Space are changing the historical relationship between CNES and its industrial partners and are encouraging a transition from a client/provider approach to a more co-partners approach. The objective of success for both parties implies active collaboration. Together, CNES and industrials manage to anticipate difficulties and accelerate project schedule. The article presents the state of the current activities around the Nanosat environment by specifying the origin of these activities and the trends that are pursued for the future.
Toxicological Analysis of Chlorhexidine in Human Serum using HPLC on a Polymer-Coated ODS Column (2002)

A simple and reliable high-performance liquid chromatographic (HPLC) method for analyzing chlorhexidine in human serum was developed. After the addition of an internal standard, levomepromazine, 0.2 mL serum was deproteinized with 10% perchloric acid. The acidic supernatant was neutralized with 1M potassium carbonate solution, and the insoluble salt was removed by centrifugation. An aliquot of the supernatant was applied to HPLC with UV detection (260 nm). HPLC separation was achieved on a polymer-coated ODS column equilibrated with acetonitrile/water containing 0.05% trifluoroacetic acid, 0.05% heptafluorobutyric acid, and 0.1% triethylamine (40:60, v/v). The calibration curve was linear in the concentration range from 0.05 to 50.0 microg/mL, and the lower limit of detection was 0.05 microg/mL. The accuracy and precision of the method were evaluated at concentrations of 0.5 microg/mL and 5.0 microg/mL. The coefficients of variation ranged from 4.0 to 4.5%. The concentration of chlorhexidine in the serum of a patient who died after a suspected intravenous injection of chlorhexidine gluconate was determined.
Immuno‐Raman microspectroscopy: In situ detection of antigens in tissue specimens by surface‐enhanced Raman scattering (2006)

Abstract We demonstrate the first realization of immuno‐Raman microspectroscopy, a novel methodology in immunohistochemistry. The in situ detection of antigens in tissue specimens is achieved by surface‐enhanced Raman scattering (SERS) from aromatic Raman labels covalently linked to the corresponding antibody. As an example of applications of this new Raman technique, we present the localization of prostate‐specific antigen (PSA) in epithelial tissue from patients with prostate carcinoma (PCA). Copyright © 2006 John Wiley &amp; Sons, Ltd.
Depression of persons with dementia and family caregiver burden: Finding positives in caregiving as a moderator (2019)

This research suggests the importance of facilitating family caregivers of dementia patients to find positives in caregiving. It provides initial data for the development of dementia caregiver burden interventions that are based on the understanding of the deep meaning of dementia caregiving. Geriatr Gerontol Int 2019; 19: 414-418.
Measuring the Financial Benefits of IT Investments on Coordination (1999)

We know from the information processing perspective within the theory of organizations that IT can reduce coordination costs by increasing an organization’s information processing capacity. Purpose of this paper is to empirically examine the relationship between greater investments in information technology and lower coordination costs on firm-level data. Two high-level measures of coordination costs are defined based on the information processing perspective within the theory of organizations. Our hypothesis that greater IT investments should be correlated with lower coordination costs is tested with both measures on longitudinal data from a cross-sectional sample of 18 large Italian companies over an 8-year period between 1988 and 1995. Results on this sample seem to support our hypothesis by showing a significant and negative correlation both aggregately and on sub-samples of data clustered by industry.
Interval and fuzzy eigenfrequency analysis of uncertain substructured FE models (2007)

This paper uses an interval and fuzzy finite element approach for the eigenfrequency analysis of a mechanical structure with uncertain parameters. The component mode synthesis method is applied for the numerical reduction of the structure, in order to reduce the calculation time of the interval and fuzzy analyses. Special attention is paid to the effect of uncertainties on the description of the substructuring technique and the consequences on the calculation time. All concepts are illustrated through a benchmark structure example. Copyright © 2007 by Institute of Fundamental Technological Research, Polish Academy of Sciences.
Supplementary Figure S2 from Mechanism of Oncogenic Signal Activation by the Novel Fusion Kinase FGFR3–BAIAP2L1 (2023)

&lt;p&gt;Morphological change and ligand independent phosphorylation of FGFR3 in Rat-2 cells or 3T3 cells&lt;/p&gt;
Rare serotype adenoviral vectors for HIV vaccine development (2011)

Human adenoviral vectors are being developed for use in candidate vaccines for HIV-1 and other pathogens. However, this approach suffered a setback when an HIV-1 vaccine using an adenovirus type 5 (Ad5) vector failed to reduce, and might even have increased, the rate of HIV infection in men who were uncircumcised and who had preexisting antibodies specific for Ad5. This increased interest in the evaluation of serologically distinct adenoviral vectors. In this issue of the JCI, Frahm and coworkers report evidence that preexisting cellular immune responses directed toward Ad5 reduce the immunogenicity of antigens expressed in Ad5-vectored vaccines and have cross-reacting potential with non-Ad5 adenoviral vectors. The implications of this observation need to be carefully evaluated in future clinical trials of all serotypes of adenovirus-vectored vaccines.
Contributions from the Structural Engineering Discipline of the Oil Industry to a Clean Environment (2003)

The structural engineering discipline of the oil industry is considering as to how the discipline could contribute to a clean environment. During preparation of a new ISO code on Arctic Offshore Structural Design, the standardization committee (ISO TC 67/SC7/WG8) has recently agreed that the code shall include a statement on the need for ensuring that all offshore structures in the Arctic shall comply with international environmental standards and that the structural engineers shall contribute during the design to a clean Arctic environment. This may be the first structural engineering code to include such a statement about the environment and it could introduce a new awareness among the structural engineers on how their contribution to a clean environment can count. Similar statements could be introduced in other structural engineering codes in the future. The paper discusses specific aspects related to structural engineering and the environment and concludes with the view that the structural engineer’s design of structures that are safe and that do not leak may represent the most significant contribution to the environment. Other aspects, such as containment of waste, are discussed as well.
Positron Emission Tomographic Imaging of Tumor Cell Death Using Zirconium-89-Labeled APOMAB® Following Cisplatin Chemotherapy in Lung and Ovarian Cancer Xenograft Models (2021)

Given that tumors, rather than normal tissues, were targeted after chemotherapy, these results support the clinical development of chDAB4 as a radiodiagnostic imaging agent and as a potential predictive marker of treatment response.