gebhart/patrepeval huggingface dataset:
Jitter correction: A computer algorithm for reduction of the velocity recovery function artifact (1988)

The measurement of neuromuscular jitter in single fiber electromyography may be artifactually raised by a component of interdischarge interval (IDI)-dependent jitter caused by the velocity recovery function (VRF) in muscle fibers. We have developed a computer algorithm for on-line mathematical correction for this artifact, thus improving the reliability of neuromuscular jitter estimates. The method, based on a modeling technique, was validated using intramuscular stimulation in order to either exclude an IDI-dependent component (using regular stimulation) or to include an IDI-dependent component (using pseudorandom stimulation). In 10 normal subjects the distribution of 106 corrected jitter values obtained using voluntary activity showed no difference from the measured values. This finding implies that previously published values for normal jitter are not likely to have been influenced by the VRF effect.
Complete Genome Sequences of Campylobacter hyointestinalis subsp. hyointestinalis Strain LMG 9260 and C. hyointestinalis subsp. lawsonii Strain LMG 15993 (2016)

Campylobacter hyointestinalis is isolated primarily from ruminants and swine, but is also occasionally isolated from humans. C. hyointestinalis is currently divided into two subspecies, C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii This study describes the first closed whole-genome sequences of C. hyointestinalis subsp. hyointestinalis isolate LMG 9260 and C. hyointestinalis subsp. lawsonii isolate LMG 15993.
Suppression of high-field (T0-S) chemically induced nuclear spin polarization (CIDNP) by successive trapping of radicals. Persistence of low-field (T1-S) CIDNP (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSuppression of high-field (T0-S) chemically induced nuclear spin polarization (CIDNP) by successive trapping of radicals. Persistence of low-field (T1-S) CIDNPJohn F. Garst, Franklin E. Barton II, and John I. MorrisCite this: J. Am. Chem. Soc. 1971, 93, 17, 4310–4312Publication Date (Print):August 1, 1971Publication History Published online1 May 2002Published inissue 1 August 1971https://pubs.acs.org/doi/10.1021/ja00746a047https://doi.org/10.1021/ja00746a047research-articleACS PublicationsRequest reuse permissionsArticle Views37Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comet Shoemaker‐Levy 9: Fragment and progenitor impact energy (1995)

Initial observational data from the impact of fragments of Comet Shoemaker‐Levy 9 (SL9) are compared with smoothed particle hydrodynamic (SPH) calculations to determine their pre‐impact diameters and the equivalent diameter of the SL9 progenitor. Diameters (solid ice) of 2.0±0.1, 2.0±0.05, 2.1±0.04 and 1.9±0.05 km for fragments A, E, G1, and W are obtained from impact‐induced plume heights from the Hubble Space Telescope (HST) data. Applying these values to scale apparent diameters for the balance of 18 SL fragments in Weaver et al.'s [1995] catalog of 22 objects yields a SL9 progenitor diameter of 5.0±1.8 km. This corresponds to total impact energy of 1.2 (+1.8−0.8) × 10 30 erg. Such an energetic event occurs on Jupiter and Earth at least every 4,900 +4,700, −2,700, and ∼0.5 × 10 8 years, respectively.
Base-Catalyzed [1,n]-Proton Shifts in Conjugated Polyenyl Alcohols and Ethers (2019)

The isomerization of dienyl alcohols and polyenyl alkyl ethers catalyzed by TBD (1,5,7-triazabicyclo[4.4.0]dec-5-ene) under metal-free conditions is presented. Two reaction pathways have been observed. For dienyl alcohols, the reaction proceeds by a [1,3]-proton shift to give γ,δ-unsaturated ketones exclusively. On the other hand, the reaction with polyenyl alkyl ethers gives the corresponding conjugated vinyl ethers in good yields (up to 85%), with regioselectivities up to >20:1. Experimental and computational investigations suggest that the mechanism proceeds through consecutive “chain-walking” proton shifts (“base walk”) mediated by TBD.
General discussion (1965)

J. J. Weiss, F. A. Long, A. J. Kresge, M. Eigen, B. E. Conway, R. P. Bell, D. B. Matthews, N. A. J. Rogers, M. Fleischmann, H. W. Nürnberg, R. Parsons, M. C. R. Symons, M. M. Kreevoy, J. R. Jones, J. R. Hulett, G. J. Hills, J. O'M. Bockris, S. G. Christov, E. F. Caldin, M. J. Henchman, R. A. Ross and P. Ausloos, Discuss. Faraday Soc., 1965, 39, 45 DOI: 10.1039/DF9653900045
Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives (2017)

Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative disease and those which will be implicated in clinical practice in the near future. Specifically, this guideline addresses the clonality test for B- and T-cell proliferative lesions, molecular cytogenetic tests for malignant lymphoma, determination of cell-of-origin in diffuse large B-cell lymphoma, and molecular genetic alterations incorporated in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Finally, a new perspective on the next-generation sequencing for diagnostic, prognostic, and therapeutic purpose in malignant lymphoma will be summarized.
[Chemotaxis defect and recurrent E. coli meningitis]. (1985)

The increased susceptibility to bacterial infections due to a decreased chemotaxis of neutrophil granulocytes was investigated in a premature small for gestational age baby, who such suffered from recurrent E. coli-meningitis. Causes as anatomic lesions, brain abscess, septic granuloumatosus disease and the Chédiak-Higashi-anomaly were ruled out. At the age of 9 and 13 weeks chemotaxis function compared to age-matched and adult controls was diminished. Addition of serum from healthy adults increased directed migration without reaching normal levels. The study of the complement status revealed a diminution of CH50, the alternate pathway components and C6-C9. Thus, decreased chemotaxis is believed to originate from a combined intrinsic-extrinsic defect. No relapses of infection were observed during prophylactic treatment with ascorbate and cotrimoxazole. Intrinsic as well as extrinsic chemotaxis became normal at the age of 7 months. Simultaneously, complement status was found to approach normal levels. The relevance of haematologic-immunologic evaluation in cases of relapsing severe bacterial infections in preterm newborns is discussed.
Application and Study of X-Gal in Isolation and Counting Bifidobacterium (2005)

Majority of Bifidobacterium have Tilactase and upper enzyme activity,so add X-Gal in the improved NPNL mediu as the substrate, Bifidobacterium hydrolysis substrate and releas indole, which induces colorresponse. Bifidobacterium colony sho dark blue ,and other Bacteria generally show white or light blu X-Gal is used to compare isolation and the count of bifidobacter um in two sam ples.This m ethod can exactly indicate the count bifidobacteria in products and babies'feces. Also it can reduc workloads of bifidobacterium 'isolation and identification.
Highly Resolved Sub-Terahertz Vibrational Spectroscopy of Biological Macromolecules and Cells (2012)

Sub-terahertz (sub-THz) vibrational spectroscopy for biosensing is based on specific resonance features, vibrational modes or group of modes at close frequencies, in the absorption (transmission) spectra of large biological molecules and entire bacterial cells/spores. Further improvements in sensitivity, especially in the discriminative capability of sub-THz vibrational spectroscopy for detection, characterization, and identification of bacterial organisms, require spectral resolution adequate to the width of spectral features. Evidences exist for long-lasting relaxation processes for atomic dynamics (displacements) resulting in narrow spectral lines and justifying the development and application of highly resolved vibrational spectroscopy. Here we describe a new continuous-wave frequency-domain spectroscopic sensor with imaging capability operating at room temperature in the sub-THz spectral region between 315 and 480 GHz. We present experimental spectra from biological macromolecules and species obtained using this spectrometer and compare some spectra with simulation results using molecular dynamics. Observed multiple intense and specific resonances in transmission/absorption spectra from nano-gram samples with spectral line widths as small as 0.1 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\rm cm}^{-1}$</tex></formula> provide conditions for reliable discriminative capability, potentially to the level of the strains of the same bacteria, and for monitoring interactions between biomaterials and reagents in near real-time.
Preincubation of Bradyrhizobium japonicum with Genistein Accelerates Nodule Development of Soybean at Suboptimal Root Zone Temperatures (1995)

In the soybean (Glycine max [L.] Merr.) N2-fixing symbiosis, suboptimal root zone temperatures (RZTs) slow nodule development, especially at temperatures below 17[deg]C. A step in the infection process that occurs within the first 24 h is particularly sensitive to suboptimal RZT. The first phase in the establishment of the soybean-Bradyrhizobium japonicum symbiosis is the exchange of recognition molecules. The most effective plant-to-bacterium signal is genistein. Binding of genistein to B. japonicum activates many of the B. japonicum nod genes. To our knowledge, the potential of sub-optimal RZT to disrupt this interorganismal signaling has not previously been investigated. Controlled environment experiments were conducted to determine whether the preincubation of B. japonicum with genistein increases soybean nodulation and N2 fixation at suboptimal RZT and whether the time between inoculation and root-hair curling is shortened by genistein application. The results of these experiments indicated that (a) genistein application increased soybean nodulation at suboptimal RZTs (17.5 and 15[deg]C) but not at the optimal RZT (25[deg]C); (b) the period between inoculation and root-hair curling was shortened by inoculation with bradyrhizobia preincubated with genistein; (c) at 17.5 and 15[deg]C RZT, the onset of N2 fixation occurred earlier in plants that received genistein-treated bradyrhizobia than in plants inoculated with untreated bradyrhizobia; (d) over the tested concentration range, genistein application at 15 to 20 [mu]M was the most effective in stimulating nodulation; and (e) between 25 and 15[deg]C, as RZT decreased, there was an increase in the nodulation-stimulating potential of genistein.
Approximation Algorithm for Sparsest k-Partitioning (2013)

Given a graph G, the sparsest-cut problem asks to find the set of vertices S which has the least expansion defined as where w is the total edge weight of a subset. Here we study the natural generalization of this problem: given an integer k, compute a k-partition {P1, …, Pk} of the vertex set so as to minimize Our main result is a polynomial time bi-criteria approximation algorithm which outputs a (1 – ∊)k-partition of the vertex set such that each piece has expansion at most times OPT. We also study balanced versions of this problem.
Thermal Decoupling of Molecular-Relaxation Processes from the Vibrational Density of States at Terahertz Frequencies in Supercooled Hydrogen-Bonded Liquids (2014)

At terahertz frequencies, the libration-vibration motions couple to the dielectric relaxations in disordered hydrogen-bonded solids. The interplay between these processes is still poorly understood, in particular at temperatures below the glass transition temperature, Tg, yet this behavior is of vital importance for the molecular mobility of such materials to remain in the amorphous phase. A series of polyhydric alcohols were studied at temperatures between 80 and 310 K in the frequency range of 0.2-3 THz using terahertz time-domain spectroscopy. Three universal features were observed in the dielectric losses, ϵ″(ν): (a) At temperatures well below the glass transition, ϵ″(ν) comprises a temperature-independent microscopic peak, which persists into the liquid phase and which is identified as being due to librational/torsional modes. For 0.65 Tg < T < Tg, additional thermally dependent contributions are observed, and we found strong evidence for its relation to the Johari-Goldstein secondary β-relaxation process. (b) Clear spectroscopic evidence is found for a secondary β glass transition at 0.65 Tg, which is not related to the fragility of the glasses. (c) At temperatures above Tg, the losses become dominated by primary α-relaxation processes. Our results show that the thermal changes in the losses seem to be underpinned by a universal change in the hydrogen bonding structure of the samples.
8. Clitic doubling, agreement and information structure: The case of Albanian (2008)

Starting from the basic facts presented in Kallulli (2000) on clitic doubling in Albanian, the goals of the present paper are threefold: first, to provide additional arguments in favour of the view that clitic doubled direct object expressions are necessarily interpreted as topical (as opposed to focal) and that topichood – and more generally, information structure – is encoded in narrow syntax; secondly, to explain how several potentially problematic phenomena under this view, such as (apparent) clitic doubling of D-linked wh -phrases and certain asymmetries in the distribution of doubling clitics in restrictive relative clauses, can be solved without giving up the core idea that clitic doubling triggers a topical interpretation of the doublee; and thirdly, to provide a formal and uniform account of all patterns of clitic doubling found in Albanian.
Le principali dinamiche della condizione economica delle famiglie modenesi tra il 2002 e il 2006 (2008)

This paper describes the changes that have taken place in the distribution of income in the province of Modena between 2002 and 2006, on the basis of the information provided by two local surveys on households? incomes and living standards. The period is characterized by very slow improvements in real average incomes, and by a significant increase in inequality and poverty levels. These changes are in contrast to what seems to have taken place in Italy as a whole, at least until 2006. Finally, we focus on a subjective measure of income poverty and on the role played by immigrants in shaping these modifications.
Abstract LB-040: SIRT1 requires for mammary stem cell self-renewal and maintenance (2019)

In spite of the many advances in cancer diagnosis and treatment, breast cancer remains a devastating disease among women worldwide. Although the critical role of estrogen (E2) in breast cancer has been unequivocally established and antiestrogens have been successfully used to treat this disease, there are about 2.6 million women in the United States who are continue to suffer from this disease. Further, approximately 80% of breast cancers are initially E2-dependent and respond well to antiestrogens, but many of them develop resistance and become unresponsive to antiestrogen therapy. Despite through investigation, the molecular mechanisms underlying this loss of responsiveness to antiestrogen therapy and the precise signaling molecules that impart E2-induced mitogenic signaling have not been fully understood. This gap in knowledge constitutes a significant impediment in effective prevention and treatment of this disease. Thus, the purpose of this study is to identify the precise signaling processes that impart E2 signaling and the molecular mechanisms underlying the resistance to hormonal therapy in breast cancer. In this study, we found that SIRT1, a type III histone deacetylase (HDAC), plays a critical role in E2-induced tumor growth as well as chemoresistance in human breast cancer cells. Functional inactivation of this gene abolished E2-induced tumor growth and made it more susceptible to hormonal- and chemotherapy-induced growth arrest and apoptosis. Additionally, our study showed that mammary stem-cells require Sirt1 for self-renewal and maintenance in the undifferentiated-state. Interestingly, mammary gland specific Sirt1-knockdown significantly reduced breast tumor growth and metastasis in syngeneic and genetically engineered mouse (GEM) models of breast cancer by limiting breast cancer stem cell (BCSC) self-renewal. RNA-seq analysis provided evidence that Sirt1 deletion is associated with significantly reduced expression of genes involved in BCSC self-renewal, tumor growth and metastasis, and drug resistance. Treatment of GEM mouse models of breast cancer with SIRT1 inhibitor reduced tumor growth with increased overall survival. Altogether, our study provides strong evidence that SIRT1 is a key regulator of E2-induced tumor growth signaling, and a potential modifier of drug resistance. Functional inactivation of this gene will effectively block mammary tumor development and circumvent drug resistance, which in turn could significantly increase the disease-free survival.Citation Format: Utkarsh Parwal, Parth Patel, Sabarish Ramachandran, Rajneesh Pathania, Allison Bridges, Pragya Rajpurohit, Puttur D. Prasad, Muthusamy Thangaraju. SIRT1 requires for mammary stem cell self-renewal and maintenance [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr LB-040.
Three Homology Models of PAR2 Derived from Different Templates: Application to Antagonist Discovery (2015)

Protease activated receptor 2 (PAR2) is an unusual G-protein coupled receptor (GPCR) involved in inflammation and metabolism. It is activated through cleavage of its N-terminus by proteases. The new N-terminus functions as a tethered ligand that folds back and intramolecularly activates PAR2, initiating multiple downstream signaling pathways. The only compounds reported to date to inhibit PAR2 activation are of moderate potency. Three structural models for PAR2 have been constructed based on sequence homology with known crystal structures for bovine rhodopsin, human ORL-1 (also called nociceptin/orphanin FQ receptor), and human PAR1. The three PAR2 model structures were compared and used to predict potential interactions with ligands. Virtual screening for ligands using the Chembridge database, and either ORL-1 or PAR1 derived PAR2 models led to identification of eight new small molecule PAR2 antagonists (IC50 10-100 μM). Notably, the most potent compound 1 (IC50 11 μM) was derived from the less homologous template protein, human ORL-1. The results suggest that virtual screening against multiple homology models of the same GPCR can produce structurally diverse antagonists and that this may be desirable even when some models have less sequence homology with the target protein.
A biological marker study of oils and sediments from the West Coast, South Island, New Zealand (1987)

Abstract The distributions of sterane and terpane classes of biological marker hydrocarbons in seven oils and in selected sediment extracts from the Westland basins region have been examined by computerised gas chromatography/mass spectrometry. Despite the moderate levels of biodegradation in several of the oils, there are molecular indicators suggesting the incorporation of higher plant derived organic materals in their source rocks. In oils from the Murchison Basin and from Madagascar Beach, there is evidence to suggest that they are of a mixed marine/terrestnal ongin. Oils from the Grey River Basin have been shown to be derived from sediments that have incorporated largely terrigenous organic materials. Moreover, high concentrations of a single diterpanoid hydrocarbon, believed to derive from plant resin constituents in both the oils and in the extracts of sediments (coals and shales) regarded as being potential source rocks, suggest that the oils and coals were derived from the same comferous plant debns. The possibility that the oils are derived from these particular coals/shales has been discounted from a comparison of molecular maturity measurements on the oils and rock extracts. Based upon these data, the Upper Cretaceous Paparoa coals of the Rapahoe sector are of insufficient thermal maturity to have sourced the oils encountered within these measures. Coals and shales comprising the sedimentary succession of the Card Creek‐1 well also appear to be of insufficient maturity to have sourced these oils.
Characterization Approaches of Femtosecond Direct Laser Writing (DLW)Modifications Inside Cubic Yag Crystals (2018)

This chapter examines direct laser writing (DLW) of waveguides inside cubic Y3Al5O12 (YAG) crystals doped with Nd3+ and their characterization. The chapter describes a mode-field analysis at 633 nm for different double track waveguides and first results on gain measurements at 1064 nm. Waveguides based on a permanent refractive index modification by femtosecond lasers were first inscribed in glasses, and later also in crystalline optical materials like silicon in an experiment. The gain was measured for different pump power and signal power levels for all three waveguide series and for non guided free propagation in the bulk. The gain was measured for different pump power and signal power levels for all three waveguide series and for non-guided free propagation in the bulk. The injected seed power was 0.07 mW, 0.21 mW, 0.66 mW and 1.08 mW, respectively, whereas the pump power was varied up to 750 mW.
Voice Forgery Using ALISP: Indexation in a Client Memory (2006)

The article deals with a technique of voice forgery using the ALISP (automatic language independent speech processing) approach. Such a technique allows the voice of an arbitrary person (the impostor) to be transformed, forging the identity of another person (the client). Our goal is to demonstrate that an automatic speaker recognition system could be seriously threatened by a transformation of this kind. For this purpose, we use a speaker verification system to calculate the likelihood that the forged voice belongs to the genuine client. Experiments on NIST 2004 evaluation data show that the equal error rate for the verification task is significantly increased by our voice transformation.