gebhart/patrepeval huggingface dataset:
Recombinant bacterial alkaline phosphatase as an immunodiagnostic enzyme. (1991)

The high turnover number of calf alkaline phosphatase (CAP) is one compelling reason for selecting it as the label in many enzyme immunoassays (EIA's). CAP's usefulness, however, is limited by its inherently low thermal stability which is even further compromised during the chemical preparation of enzyme: antibody conjugates. Bacterial alkaline phosphatase (BAP) could be an attractive alternative to CAP in view of the former's extreme thermotolerance at temperatures as high as 95 degrees C. BAP has not been commonly used in EIA's however, because of its low to moderate catalysis rate. Site-directed mutagenesis was used to overcome BAP's low enzymatic activity and create a protein possessing two desired characteristics: high thermostability and high specific activity. A3-35 fold increased activity over wild-type BAP was obtained in ten different recombinant (r)BAP's via introductions of single-point mutations. The turnover number of the most active mutant, D101S, was shown to be only 1.7-times lower than CAP. This dramatic improvement enables rBAP (D101S) to compete with CAP as a viable alternative label in EIA's. The thermostability of all ten rBAP remained significantly higher than CAP although none were as thermostable as the native BAP. Enzyme:antibody conjugates were prepared with the recombinant enzymes and compared to similarly prepared CAP:antibody conjugates with different Abbott IMx assay protocols and reagents. Excellent correlation between standard curves generated with CAP- and rBAP-containing conjugates were obtained. Furthermore, this correlation was obtained using concentrations of rBAP that were only two times greater than that of CAP. The thermostabilities of the conjugates were also evaluated.(ABSTRACT TRUNCATED AT 250 WORDS)
Inactive renin release from the human arm vascular wall during upper arm occlusion: relation to beta-adrenoceptors. (1991)

To investigate the extrarenal release of renin, plasma active renin (PAR) and plasma trypsin activatable or inactive renin (PIR) in blood taken simultaneously from bilateral median cubital veins were measured in seven normal men before and after occlusion of the right upper arm with a standard cuff inflated halfway between systolic and diastolic blood pressures for 15 min. After 15 min, both PAR (P less than 0.05) with PIR (P less than 0.01) increased significantly in occluded arms compared with 0 min. PIR rose significantly (P less than 0.01) in occluded arms compared with controls at 15 min, but PAR was unchanged. The same studies were repeated after pretreatment with oral doses of either 1 mg prazosin or 10 mg propranolol at 1600 h and 2400 h on the previous day and 1 hour before the experiment. After prazosin, both PAR (P less than 0.05) and PIR (P less than 0.01) in occluded arms increased significantly at 15 min compared with those at 0 min and PIR rose significantly (P less than 0.01) in occluded arms compared with controls at 15 min, as observed in the control studies. On the other hand, after propranolol, the significant increment of PAR in the occluded arms was abolished. Moreover, the significant difference of PIR between the occluded and the control arms at 15 min was also abolished. These results indicate that inactive renin may be present in the vascular wall of the arm and released into circulation by a stimulus such as arm occlusion by mechanisms related to beta-adrenoceptors.
Antimicrobial prophylaxis in upper gastrointestinal, biliary, stomach and oesophageal surgery. (1990)

Start, duration and type of antimicrobial effect are decisive factor in prophylaxis in elective gastrointestinal surgery. Using a single dose regimen of 400 mg doxycycline and 1,600 mg tinidazole immediately prior to surgery a highly significant reduction of postoperative infectious complications was achieved in colorectal, gastric, small bowel and biliary surgery. Even after 10 years of regular use, no signs of clinical resistance have emerged with a wound infection rate of 1.2%. In Norway there is today no reason to introduce cephalosporins, penems or quinolones in prophylaxis of gastrointestinal surgery.
Nanoshell Assisted Cancer Therapy: Numerical Simulations (2009)

Since the near infrared spectrum (wavelength range of 750–1100 nm) is the region of highest physiological transmisivity, it is the optical communication gateway for the laser energy to propagate into the human body. This optical window also leads to nanoparticle-based approach where embedded nanoparticles absorb the laser light designed to address the specific diagnostic and therapeutic challenges of cancer therapy is exploited extensively in so called plasmonic photo thermal therapy (PPTT). A new tool that is under development for cancer/tumor treatment, in which embedded nanoparticles are manipulated to absorb the Near Infrared (NIR) laser light intensely, aiming at addressing the “nonselectivity” problem that exists in the conventional photo thermal therapy (PPT). The purpose is to seek therapy with a faster and accurate procedure with a comprehensive treatment plan aided with fast and accurate numerical simulations as well. Among all the nanostructures, the noble metal nanoparticles (such as nanoshells) could be tuned to have peak absorption cross section in the NIR spectrum which provide very intense local heating to burn the deeply embedded cancerous tissues and tumors rather than the healthy tissue. Experimental and numerical studies have shown that designed gold nanoshells can be used to remotely and optically induce hyperthermia by embedding certain amount of absorbing dominated gold nanoshells in tumors and then irradiated using NIR laser light. Advancing our capabilities such as modeling, characterization and design of complex nanostructures and their host media for various nanophotonic applications will also increase our effectiveness of induced hyperthermia for its future applications. The computational tools should bridge across the scales from nano to macro, and rapidly compare the predicted behavior of a large number of nanoparticles embedded in tissue so that experimental groups could concentrate laboratory efforts on those resulted configurations most likely to provide optimum results.
Red tape (1945)

Red tape Get access H. A. H. A. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 188, Issue 13, 30 June 1945, Page 281, https://doi.org/10.1093/nq/188.13.281a Published: 30 June 1945
The Anatomical and Pathological Characteristics of Irradiated Prostate Cancers May Influence the Oncological Efficacy of Salvage Ablative Therapies (2007)

The anatomical and pathological features in our study demonstrate that a significant portion of irradiated cancers are pathologically advanced and distributed in regions of the prostate (apical and periurethral) which are at risk for undertreatment using current ablative therapies. Our findings raise serious concerns regarding the oncological efficacy of such treatment modalities. Long-term studies without the use of hormonal therapy are needed to determine the oncological efficacy of salvage ablative therapies in patients with radiorecurrent or resistant prostate cancer.
Etonogestrel (Implanon), Another Treatment Option for Contraception (2008)

At the time of this writing, both authors were Managed Care Pharmacy Practice Residents at Kaiser Permanente in Atlanta, Georgia. Dr. Maddox is currently the Drug Informatics and Drug Information Specialist at Kaiser Permanente in Atlanta. Dr. Rahman is a Solid Organ Transplant Pharmacist with the University of Alabama at Birmingham. Drug Forecast is a regular column coordinated by Alan Caspi, PhD, PharmD, MBA, President of Caspi & Associates in New York, New York.
Collaboration And Awareness Amongst Flight Attendants (2017)

Collaboration is a core component of work activities amongst flight attendants as they work to promote onboard safety and a high level of customer service. Yet we know little of how flight attendants collaborate and whether or not technology adequately supports their practices. Through an interview study with flight attendants, we explored their collaborative practices and processes and how technology aided such practices. While technologies like interphones and flight attendant call buttons acted as collaboration tools, we identified instances where the usability and functionality of these devices were the main barriers for maintaining efficient communication, situation awareness, and information exchange. Our findings inform the design of future technologies for enhancing communication and collaboration in an aircraft setting amongst flight attendants with an emphasis on real time information access and direct communication between flight attendants regardless of their location.
TYPE FACES (1923)

Journal Article TYPE FACES Get access V. S. V. S. Search for other works by this author on: Oxford Academic Google Scholar The Library, Volume s4-IV, Issue 2, 1 September 1923, Pages 158–159, https://doi.org/10.1093/library/s4-IV.2.158 Published: 01 September 1923
Management of hybrid (AC-DC) micro-grids (2013)

The objective of this paper is to demonstrate the sharing of demanded power in a single-phase hybrid micro grid operating in autonomous island mode. We assume that we have DC power sources such as a photovoltaic array and wind turbine in the DC sub-grid that are tied to the AC sub-grid consisting of two uninterruptible power sources (UPS) through a bi-directional single phase inverter. Demand-droop control is used to manage power sharing between power sources in each sub-grid; however, managing the power flow through the entire grid is still a challenge. To overcome this we develop droop control strategies for each sub-grid, and droop control for the interfacing converter. Simulation results using MATLAB are used to demonstrate the performance of the power sharing methodology developed. Four different scenarios have been tested: (1) both sub-grids are heavy loaded, (2) both sub-grids have are lightly loaded, (3) a heavy DC load with a light AC load, and (4) a heavy AC load with a light DC load.
Psychosocial Outcomes Following Long-term, Double-blind Treatment of Chronic Depression With Sertraline vs Placebo (2002)

These results indicate that long-term treatment of chronic forms of depression can result in sustained psychosocial benefits. Discontinuation of treatment results in frequent reemergence of symptoms and loss of psychosocial gains. Long-term treatment resulted in only modest further improvement of psychosocial measures over that achieved in the short-term phase.
Underwater Work Measurement Techniques (1971)

Abstract : The fourth and concluding report is given in a series describing yearly progress of the UCLA Research Project on optimum underwater work measurement techniques. The previous reports have covered studies conducted in 1967, 1968 and 1969. This report, in addition to presenting the two major studies carried out in 1970, also provides a summary of work over the four year period. The cumulative list of project publications allows the reader to identify a topic of concern, determine primary findings, and explore the topic further in the literature or by reprint request.
Suppression of the speckle noise in solid polymer samples: a light scattering study (1994)

The speckle effect disturbs the measurement of spatial correlation functions in solid polymer samples by light scattering. To be able to extract the desired correlations from the measurements, the speckle noise must be suppressed. This is possible by moving the sample during the measurement. In this paper we demonstrate that a sufficient reduction of speckle contrast can be achieved even in samples of restricted dimensions or with a preferential direction.
Linking molecular characteristics to the pharmacological response of a panel of cancer cell lines to the BRAF inhibitor, AZ628 (2007)

5249 The Ras/Raf/MEK/ERK pathway is activated in approximately 30% of all human tumors. Activating mutations of BRAF have been reported in multiple tumor types, including melanoma, papillary thyroid and colon cancer. In this study we determined the response of a panel of cancer cell lines with known RAS and BRAF status to AZ628, a BRAF inhibitor. AZ628 is a potent and selective RAF kinase inhibitor with IC50 values against V600E mutant BRAF and wild type BRAF of 34nM and 91nM, respectively. AZ628 potently inhibited PMA-stimulated AP1 reporter activity in 293T cells with an IC50 value 32μM. 34% (24/70) lines were responsive (GI50s
Seropositivity to human herpesvirus 8 in relation to sexual history and risk of sexually transmitted infections among women (2000)

The mode of transmission of human herpesvirus 8 (HHV8) was investigated in two seroepidemiological studies of Swedish women who completed a questionnaire about sexual behavior. Seropositivity for HHV8 antibodies, measured using an indirect immunofluorescence assay, was linked to a high number (>10) of sexual partners (P < 0.004). It also correlated strongly with a history of other sexually transmitted diseases (STD; P < 0.0001), in particular with a history of Chlamydia trachomatis infection and condyloma acuminata. There was appreciable HHV8 seropositivity already among virginal or monogamous women (9%). In summary, HHV8 transmission to women in Sweden may occur nonsexually. When sexual transmission occurs, it appears to be associated with high risk-taking sexual behavior. Int. J. Cancer 87:232–235, 2000. © 2000 Wiley-Liss, Inc.
Preparation and Dielectric Properties of 3-3 Lead Zirconate/Polyvinylidene Fluoride Nanocomposite (2013)

Composites made of electroactive ceramics and a ferroelectric polymer are very attractive for applications since they exhibit good piezoelectric and pyroelectric properties, low densities and their properties can be tailored to various requirements. Here, we reported the preparation and dielectric properties of 3-3 PZ/PVDF nanocomposites by infusion of polyvinylidenedifluoride (PVDF) into the PZ nanofiber mat followed by heating of the composite at 80°C. The 3-3 PZ/PVDF composites were characterized by X-ray diffraction, FT-IR, SEM and LCR meter. The dielectric constant of the PZ/PVDF nanocomposite are relatively stable in the range of 21.98–18.21 within the measurement frequencies from 100 Hz to 2 MHz. This value is higher than the dielectric constant of the polyvinylidene fluoride. Moreover, the dielectric loss of the composite is below 0.09 at low frequencies.
Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes (2016)

In this large-scale metabolite profiling study, body mass index was associated with a broad range of metabolic alterations. Metabolite profiling highlighted considerable overlap with abdominal adiposity, insulin resistance, and dyslipidemia, but not with fasting glucose or blood pressure traits.
On the direct determination of three-dimensional crystallographic phases at low resolution: Crambin at 6 Å (2000)

Using a pseudo-atom approach, the three-dimensional crystallographic phases for the protein crambin (a = 40.76, b = 18.49, c = 22.33 A, beta = 90.61 degrees, space group P2(1)) were determined to 6 A by direct methods. First, the centrosymmetric h0l set was assigned phases by symbolic addition, and the initial solution was then refined by Fourier methods. Phase values of strong reflections were then permuted, and the decision to change the phase value for two of these was made by consulting a cross-correlation of the experimental density histogram to the theoretical or known histogram for the protein. The two-dimensional basis was then extended by the Sayre equation into three dimensions by assigning a phase to a third allowed hkl origin-defining reflection and an algebraic value to another axial reflection. The correct solution was again identified by the histogram correlation, yielding a solution in which the mean phase error for all 98 reflections was 61.5 degrees or 23.1 degrees for the 21 most intense reflections. A parallel study with another protein indicates this method may have general utility.
Near Infrared Spectroscopy for High-Throughput Characterization of Shea Tree (Vitellaria paradoxa) Nut Fat Profiles (2010)

The Shea tree (Vitellaria paradoxa) is a major tree species in African agroforestry systems. Butter extracted from its nuts offers an opportunity for sustainable development in Sudanian countries and an attractive potential for the food and cosmetics industries. The purpose of this study was to develop near-infrared spectroscopy (NIRS) calibrations to characterize Shea nut fat profiles. Powders prepared from nuts collected from 624 trees in five African countries (Senegal, Mali, Burkina Faso, Ghana and Uganda) were analyzed for moisture content, fat content using solvent extraction, and fatty acid profiles using gas chromatography. Results confirmed the differences between East and West African Shea nut fat composition: eastern nuts had significantly higher fat and oleic acid contents. Near infrared reflectance spectra were recorded for each sample. Ten percent of the samples were randomly selected for validation and the remaining samples used for calibration. For each constituent, calibration equations were developed using modified partial least squares (MPLS) regression. The equation performances were evaluated using the ratio performance to deviation (RPD(p)) and R(p)(2) parameters, obtained by comparison of the validation set NIR predictions and corresponding laboratory values. Moisture (RPD(p) = 4.45; R(p)(2) = 0.95) and fat (RPD(p) = 5.6; R(p)(2) = 0.97) calibrations enabled accurate determination of these traits. NIR models for stearic (RPD(p) = 6.26; R(p)(2) = 0.98) and oleic (RPD(p) = 7.91; R(p)(2) = 0.99) acids were highly efficient and enabled sharp characterization of these two major Shea butter fatty acids. This study demonstrated the ability of near-infrared spectroscopy for high-throughput phenotyping of Shea nuts.
UWB Ranging Based on Partial Received Sub-Band Signals in Dense Multipath Environments (2010)

In this paper, an Ultra-Wideband (UWB) receiver scheme with very low sampling rate is proposed for ranging in indoor multipath environments. The idea underlying the proposed scheme is that, instead of processing the whole UWB band, only partial sub-bands are considered at the receiver. The missing sub-bands are estimated by exploiting an estimate of the frequency correlation properties of the channel to reconstruct the signal over the whole UWB band. For the simulations, the IEEE UWB channel model is used and the range error using the proposed receiver scheme is obtained and compared to that of conventional UWB receivers which require very high sampling rates. Furthermore, a large number of UWB channel measurements in an office environment has been used to validate the accuracy of the obtained results. These results show that the range accuracy strongly depends on the number of received sub-bands and the spacing between them. For instance, using 1% of the total UWB bandwidth, an average range error of less than 10 cm is obtained. Furthermore, unlike conventional UWB receivers, the proposed technique performs better (in terms of range error) for low signal-to-noise ratios.
Additions and Corrections - Henry Gilman (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - Henry GilmanRobert BenkeserCite this: J. Org. Chem. 1982, 47, 27, 5426Publication Date (Print):December 1, 1982Publication History Published online16 October 2003Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/jo00148a600https://doi.org/10.1021/jo00148a600research-articleACS PublicationsRequest reuse permissionsArticle Views36Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Real-time instruction-cycle-based dynamic voltage scaling (iDVS) power management for low-power digital signal processor (DSP) with 53% energy savings (2012)

This paper presents an instruction-cycle-based dynamic voltage scaling (iDVS) power management strategy for a low-power processor design. The iDVS technique is fully compatible with conventional DVS scheduler algorithms. Furthermore, an additional iDVS design flow embedded in the standard cell lib flow is proposed to implement the iDVS-based DSP. In addition, the fast-response bidirectional asynchronous wave-pipeline (BAWP) digital low-dropout (LDO) regulator is also presented to improve the iDVS performance. The iDVS-based DSP chip implemented in an HH-NEC 0.18μm standard CMOS process demonstrates 53% energy savings over that without the iDVS technique.
Company for the ultra-high density, ultra-short period sub-Earth GJ 367 b: discovery of two additional low-mass planets at 11.5 and 34 days (2023)

GJ 367 is a bright (V $\approx$ 10.2) M1 V star that has been recently found to host a transiting ultra-short period sub-Earth on a 7.7 hr orbit. With the aim of improving the planetary mass and radius and unveiling the inner architecture of the system, we performed an intensive radial velocity follow-up campaign with the HARPS spectrograph -- collecting 371 high-precision measurements over a baseline of nearly 3 years -- and combined our Doppler measurements with new TESS observations from sectors 35 and 36. We found that GJ 367 b has a mass of $M_\mathrm{b}$ = 0.633 $\pm$ 0.050 M$_{\oplus}$ and a radius of $R_\mathrm{b}$ = 0.699 $\pm$ 0.024 R$_{\oplus}$, corresponding to precisions of 8% and 3.4%, respectively. This implies a planetary bulk density of $ρ_\mathrm{b}$ = 10.2 $\pm$ 1.3 g cm$^{-3}$, i.e., 85% higher than Earth's density. We revealed the presence of two additional non transiting low-mass companions with orbital periods of $\sim$11.5 and 34 days and minimum masses of $M_\mathrm{c}\sin{i_\mathrm{c}}$ = 4.13 $\pm$ 0.36 M$_{\oplus}$ and $M_\mathrm{d}\sin{i_\mathrm{d}}$ = 6.03 $\pm$ 0.49 M$_{\oplus}$, respectively, which lie close to the 3:1 mean motion commensurability. GJ 367 b joins the small class of high-density planets, namely the class of super-Mercuries, being the densest ultra-short period small planet known to date. Thanks to our precise mass and radius estimates, we explored the potential internal composition and structure of GJ 367 b, and found that it is expected to have an iron core with a mass fraction of 0.91$^{+0.07}_{-0.23}$. How this iron core is formed and how such a high density is reached is still not clear, and we discuss the possible pathways of formation of such a small ultra-dense planet.