gebhart/patrepeval huggingface dataset:
Hybrid energy storage systems based on compressed air and supercapacitors with maximum efficiency point tracking (2005)

Beside the high-capacity storage facilities based on hydro-power technologies, electrochemical solutions are the today's candidate for storage for renewable energy sources. However, limited life-cycles and sustainability of batteries are often inhibiting factors. This paper presents a hybrid energy storage system with high life cycle, based on compressed air energy storage (CAES). The storage and discharge are done within maximum efficiency conditions. As the maximum efficiency conditions impose the level of converted power, an intermittent time-modulated operation mode is applied to the thermodynamic converter to obtain a variable converted power. A smoothly variable output power is achieved with the help of a supercapacitive auxiliary storage device used as a filter. The paper describes the concept of the system, the power-electronic interface circuits and especially the maximum efficiency point tracking (MEPT) algorithm and the strategy used to vary the output power. In addition, the paper describes the principles of higher efficiency storage systems where the air machine is replaced by an oil hydro-pneumatic converter, used under isothermal conditions. Practical results are reported, that have been recorded from a low-power pneumatic motor coupled to a small DC generator for the purely pneumatic system, and from a first prototype of the oil-hydraulics and pneumatic system. Some economical considerations are also made, through a comparative cost evaluation of the presented hydro-pneumatic systems and a lead acid batteries system, in the context of a stand alone photovoltaic home application. This evaluation confirms the cost effectiveness of the studied hybrid storage systems
Human Retina-on-a-Chip: Merging retinal organoids with Organ-on-a-Chip technology (2019)

Abstract 3317
Genetic variation in the chloroplast genome suggests multiple domestication of cultivated Asian rice (Oryza sativa L.) (2007)

Two hundred and seventy-five accessions of cultivated Asian rice and 44 accessions of AA genome Oryza species were classified into 8 chloroplast (cp) genome types (A-H) based on insertion-deletion events at 3 regions (8K, 57K, and 76K) of the cp genome. The ancestral cp genome type was determined according to the frequency of occurrence in Oryza species and the likely evolution of the variable 57K region of the cp genome. When 2 nucleotide substitutions (AA or TT) were taken into account, these 8 cp types were subdivided into 11 cp types. Most indica cultivars had 1 of 3 cp genome types that were also identified in the wild relatives of rice, O. nivara and O. rufipogon, suggesting that the 3 indica cp types had evolved from distinct gene pools of the O. rufipogon - O. nivara complex. The majority of japonica cultivars had 1 of 3 different cp genome types. One of these 3 was identified in O. rufipogon, suggesting that at least 1 japonica type is derived from O. rufipogon with the same cp genome type. These results provide evidence to support a polyphyletic origin of cultivated Asian rice from at least 4 principal lineages in the O. rufipogon - O. nivara complex.
Convergence of multiple nuclear receptor signaling pathways onto the long terminal repeat of human immunodeficiency virus-1. (1994)

A composite element that interacts with multiple nuclear receptors has been identified in the long terminal repeat (LTR) of the human immunodeficiency virus-1 (HIV-1). This element, designated nuclear receptor-responsive element (NRRE), spans the -356 to -320 LTR region and contains tightly clustered binding sites for the retinoid X receptor-alpha (RXR alpha) and for five nuclear receptors with unknown ligands, apolipoprotein AI regulatory protein-1 (ARP-1), v-erbA-related proteins-2 and -3 (EAR-2 and EAR-3), hepatocyte nuclear factor-4 (HNF-4), and nerve growth factor-inducible protein-B (NGFI-B). The NRRE also interacts with heterodimers formed between RXR alpha and either ARP-1, EAR-2, EAR-3, the retinoic acid receptor-alpha (RAR alpha), or the peroxisome proliferator-activated receptor (PPAR). Remarkably, nuclear receptor binding is conserved in the LTRs of recently evolved HIV-1 strains but it is absent in the oldest and most divergent viral isolates, raising the intriguing possibility that the NRRE has been evolved recently in the viral genome. Cotransfection experiments in human choriocarcinoma JEG-3 cells have shown that the HIV-1 LTR-driven transcription is activated by RXR alpha and RAR alpha in the presence of 9-cis- and all-trans-retinoic acid, by PPAR and RXR alpha in the presence of clofibric acid and 9-cis-retinoic acid, and by the "orphan" receptors HNF-4 and NGFI-B. These findings suggest that a complex network of nuclear receptor signaling pathways, that include 9-cis- and all-trans-retinoic acid, fatty acids, peroxisome proliferators, growth factors, membrane depolarization, and possibly other signals, converge onto the HIV-1 NRRE and may participate in modulation of viral gene expression.
Spectral analysis of erythrocyte flickering in the 0.3–4-μm−1regime by microinterferometry combined with fast image processing (1992)

Reflection interference microscopy in combination with real-time image processing was applied to determine the spatial spectrum of the mean-square amplitude of erythrocyte flickering in the wave-vector regime 0.3\ensuremath{\le}q\ensuremath{\le}4 \ensuremath{\mu}${\mathrm{m}}^{\mathrm{\ensuremath{-}}1}$. The mean-square amplitude scales as ${\mathit{q}}^{4\ifmmode\pm\else\textpm\fi{}\mathrm{\ensuremath{\epsilon}}}$ for q\ensuremath{\ge}0.7 \ensuremath{\mu}${\mathrm{m}}^{\mathrm{\ensuremath{-}}1}$, suggesting that flickering is dominated mainly by bending stiffness. We measured a bending modulus of ${\mathit{K}}_{\mathit{c}}$=(2\ifmmode\pm\else\textpm\fi{}0.5)\ifmmode\times\else\texttimes\fi{}${10}^{\mathrm{\ensuremath{-}}20}$ N m as compared to ${\mathit{K}}_{\mathit{c}}$=(5\ifmmode\pm\else\textpm\fi{}1.5)\ifmmode\times\else\texttimes\fi{}${10}^{\mathrm{\ensuremath{-}}20}$ N m found for dimyristoylphosphatidylcholine (DMPC) vesicles with the same technique.
Фоточувствительные полимерные волноводы на основе антраценоилацетоната дифторида бора (2014)

The possibility of using the new dopant anthracene oil acetonate boron difluoride (2,2-difluoro-4-(9-anthracyl)6-methyl-1,3,2-dioxaborin) to provide photosensitivity to waveguide structures made of polymethyl methacrylate was demonstrated. Doped polymethyl methacrylate may be applied for making strip waveguides with attenuation of less than 2 dB/cm and planar phase diffraction gratings with a spatial frequency of up to 3000 mm-1 and the diffraction efficiency of up to 50 % in the waveguide mode using laser method.
A ‘one tube reaction’ for synthesis and amplification of total cDNA from small numbers of cells (1993)

Journal Article A ‘one tube reaction’ for synthesis and amplification of total cDNA from small numbers of cells Get access Robert H. Don, Robert H. Don Centre for Molecular Biology and Biotechnology, The University of QueenslandBrisbane, Qld 4072, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter T. Cox, Peter T. Cox Centre for Molecular Biology and Biotechnology, The University of QueenslandBrisbane, Qld 4072, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar John S. Mattick John S. Mattick Centre for Molecular Biology and Biotechnology, The University of QueenslandBrisbane, Qld 4072, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 21, Issue 3, 11 February 1993, Page 783, https://doi.org/10.1093/nar/21.3.783 Published: 11 February 1993 Article history Received: 19 October 1992 Revision received: 07 December 1992 Accepted: 07 December 1992 Published: 11 February 1993
In Vivo Phenotypic Dominance in Mouse Mixed Infections withMycobacterium tuberculosisClinical Isolates (2005)

Clinical isolates of Mycobacterium tuberculosis demonstrate significant heterogeneity in virulence potential in animal models of infection. Isolate CDC1551, for example, has previously been described in mouse survival studies as being hypovirulent, and isolate HN878 has been described as being hypervirulent. Observed differences in this mouse infection experiment have been proposed to reflect differential engagement of the host immune response. To assess whether this is a local or a systemic effect, C57BL/6 mice were infected simultaneously with mixtures of CDC1551 and HN878 in varying ratios and were monitored for mycobacterial growth kinetics, strain proportions during infection, and mouse survival. Strain mixtures that contained primarily HN878 grew more quickly during the first 5 weeks of infection and were more lethal for mice, and HN878 was enriched during in vivo growth. The absolute number of implanted HN878 bacilli at infection correlated inversely with mouse survival and was independent of concomitant infection with CDC1551. In infections of nonactivated mouse macrophages, HN878 grew more quickly. However, phagocyte preactivation reduced and equalized the growth rate of both strains. These results suggest that HN878 exerts a dominant immunosuppressive effect limited to the granuloma in which it is contained.
Learning with Structured Sparsity (2009)

This paper investigates a learning formulation called structured sparsity, which is a natural extension of the standard sparsity concept in statistical learning and compressive sensing. By allowing arbitrary structures on the feature set, this concept generalizes the group sparsity idea that has become popular in recent years. A general theory is developed for learning with structured sparsity, based on the notion of coding complexity associated with the structure. It is shown that if the coding complexity of the target signal is small, then one can achieve improved performance by using coding complexity regularization methods, which generalize the standard sparse regularization. Moreover, a structured greedy algorithm is proposed to efficiently solve the structured sparsity problem. It is shown that the greedy algorithm approximately solves the coding complexity optimization problem under appropriate conditions. Experiments are included to demonstrate the advantage of structured sparsity over standard sparsity on some real applications. © 2011 Junzhou Huang, Tong Zhang and Dimitris Metaxas.
Methylprednisolone for Acute Spinal Cord Injury: 5-Year Practice Reversal (2008)

Over a five year period there has been a complete reversal in practice patterns of MP administration for SCI, along with an increased familiarity of the published literature. Attendance at meetings, participation in local group discussions, and peer-reviewed publications appear effective in altering practice preferences arising from peer pressure and even fear of litigation.
Turbine Shape Organotin Dendrimers:  Photophysical Properties and Direct Replacement of Sn with Pt (2008)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTTurbine Shape Organotin Dendrimers: Photophysical Properties and Direct Replacement of Sn with PtRami Hourani, Michael A. Whitehead, and Ashok KakkarView Author Information Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6 Canada Cite this: Macromolecules 2008, 41, 3, 508–510Publication Date (Web):January 11, 2008Publication History Received2 October 2007Revised29 November 2007Published online11 January 2008Published inissue 1 February 2008https://doi.org/10.1021/ma702203uCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views431Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (77 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Dendrons,Hydrocarbons,Molecular structure,Molecules,Quantum yield Get e-Alerts
Resistance to Replication of Human Immunodeficiency Virus Challenge in SCID-Hu Mice Engrafted with Peripheral Blood Mononuclear Cells of Nonprogressors Is Mediated by CD8+T Cells and Associated with a Proliferative Response to p24 Antigen (2000)

High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8(+) T cells in vivo and was observed only in LTNPs with proliferative responses to p24. In a subgroup of nonprogressors, CD8(+) T cells mediated restriction of challenge viruses, and this response was associated with strong proliferative responses to p24 antigen.
Game changer in the diagnosis of bipolar disorder using RNA editing-based blood biomarkers (2021)

Introduction In clinical practice, differentiating Bipolar Disorder (BD) from unipolar depression is challenging due to the depressive symptoms, which are the core presentations of both disorders. Patients with BD are often misdiagnosed during depressive episodes resulting in a delay in proper treatment and a poor management of their condition. Objectives The aim of the present study is to discriminate between unipolar depression and BD using a panel of RNA edited blood biomarkers. Methods Depressed patients were classified according to clinical scores in MADRS and IDSC-30 depression scales. After blood collection and RNA extraction, we used whole-transcriptome sequencing to identify differential A-to-I editing events, and Targeted Next Generation Sequencing to validate those biomarkers. Results We discovered 646 variants differentially edited between depressed patients and control in a discovery cohort of 57 participants. After using stringent criteria and biological pathway analysis, 6 biomarker candidates were singled out and tested in a validation cohort of 160 patients suffering from unipolar depression and 95 BD patients in a depressive episode, which allowed a differential diagnosis of BD with an AUC of 0.935 and high specificity (Sp=84.6%) and sensitivity (Se=90.9%). Conclusions We have shown that a combination of 6 blood RNA editing-related biomarkers allows to discriminate unipolar and bipolar depression This 6 BMKs panel may be crucial to improve BD diagnosis and orientate the treatment therefore addressing the needs of millions of patients suffering from misdiagnosis and incorrect treatment for their diseases. This will change the game for the management of patients. Disclosure No significant relationships.
A MEMBRANE TNF-α/TNFR RATIO CORRELATES TO MODS SCORE AND MORTALITY (1996)

This study hypothesizes that post-trauma elevated membrane-associated tumor necrosis factor-alpha (mTNF) and decreased TNF receptor shedding may be more related to development of multiple organ dysfunction syndrome (MODS) than elevated secreted TNF-alpha. We also address several of the possible reasons for the previous conflicting reports in studies correlating trauma patients sera TNF-alpha levels to their clinical outcome. These are 1) the lack of an objective quantitative score of clinical illness severity, 2) the lack of multiple TNF-alpha measurements in one patient to allow for trend analysis, 3) the lack of analysis of membrane-associated as well as secreted TNF-alpha levels, 4) the lack of concomitant analysis of soluble TNF-alpha receptors which may bind TNF-alpha in the serum, and 5) the possible requirement for more than one dysfunction in monocyte (M phi) TNF-alpha production and regulation to initiate pathology. Here, the MODS score was used to quantitate patients' illness severity over the length of their intensive care unit (ICU) stay. Patients' and normals' monocytes (stimulated and unstimulated) were assessed for production of secreted as well as membrane-associated TNF-alpha (sTNF and mTNF) and for shed p75 TNF-alpha receptor (TNFR) levels. These parameters of M phi TNF-alpha production and regulation were correlated to the MODS score as an indicator of clinical outcome. There was no correlation between sTNF and MODS score (p = .9025). There was a correlation between increased mTNF (p = .057) or decreased TNFR shedding (p = .0021) to increased MODS, but this lacked specificity. However, when the stimulated M phi production of mTNF and TNFR are expressed as the mTNF/TNFR ratio, an increased ratio correlates with high specificity to development of organ failure (p = .0002). These data indicate that a dual deregulation in M phi TNF-alpha production reflects increasing mTNF-alpha levels concomitant to decreased M phi shedding of neutralizing TNFR and correlates with the development of MODS.
SHORT COMMUNICATION: Regulated expression of APE apurinic endonuclease mRNA during wound healing in porcine epidermis (1996)

Abasic (AP) sites in DNA are cytotoxic and mutagenic and their repair is initiated by AP endonucleases. The major AP endonuclease of mammalian cells is encoded by the APE gene. Ape protein has also been proposed to modulate the activity of some transcription factors independently of its AP endonuclease activity. We investigated whether APE expression is coordinated with cell division, which could diminish mutagenesis. The level of APE mRNA was followed during wound healing in porcine epidermis, in which surgical wounding prompts rapid cell proliferation followed by a differentiation program to regenerate normal skin. In situ hybridization with a probe from human APE cDNA revealed strongly decreased expression in rapidly proliferating migrating cells during the first 1-3 days following wounding, succeeded by sharply increased APE expression that exceeded the pre-wounding levels by days 9-17. These changes were not observed in the surrounding undamaged tissue. In contrast to the foregoing in vivo results, APE expression in cultured primary human fibroblasts (IMR90) or myeloid leukemia cells (K562) was not coordinated with cell division. This biphasic APE expression during wound healing could relate to transcription factor regulation or it could allow unhindered DNA synthesis or prepare the developing epidermis to handle DNA damage. However, if transient under-expression of APE-encoded repair enzyme does occur, it might render regenerating skin especially vulnerable to mutagenesis during the cell proliferation phase.
The effect of MR surface coils on PET quantification in whole-body PET/MR: Results from a pseudo-PET/MR phantom study (2011)

Unaccounted attenuation from MR surface coils causes a regional bias of AC-PET data in body regions near the MR coils. Bias of central regions was more noticeable in smaller-size objects. In torso studies with body surface coils, the visibility of central lesions on PET was unaffected by MR coils following incomplete AC. Coil misalignment of several cm between emission and attenuation images causes an error that was comparable to that arising from unaccounted MR coil attenuation but small compared to the average standard deviation of the activity concentration levels.
Supplementary Table from Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma (2023)

Supplementary Table from Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma
DCAN: Deep Contour-Aware Networks for Accurate Gland Segmentation (2016)

The morphology of glands has been used routinely by pathologists to assess the malignancy degree of adenocarcinomas. Accurate segmentation of glands from histology images is a crucial step to obtain reliable morphological statistics for quantitative diagnosis. In this paper, we proposed an efficient deep contour-aware network (DCAN) to solve this challenging problem under a unified multi-task learning framework. In the proposed network, multi-level contextual features from the hierarchical architecture are explored with auxiliary supervision for accurate gland segmentation. When incorporated with multi-task regularization during the training, the discriminative capability of intermediate features can be further improved. Moreover, our network can not only output accurate probability maps of glands, but also depict clear contours simultaneously for separating clustered objects, which further boosts the gland segmentation performance. This unified framework can be efficient when applied to large-scale histopathological data without resorting to additional steps to generate contours based on low-level cues for post-separating. Our method won the 2015 MICCAI Gland Segmentation Challenge out of 13 competitive teams, surpassing all the other methods by a significant margin.
A new approach for thresholding spectral change detection using multispectral and hyperspectral image data, a case study over Sokolov, Czech republic (2014)

AbstractChange detection and multitemporal analyses aim to detect changes occurring over a specific geographical area using two or more images acquired at two or more different times. In this article, we present a new thresholding approach for unsupervised change detection. This approach focuses on determining the threshold that discriminates between change and no-change pixels. The differences between pixels in the two images are associated with real changes or noise. We propose a thresholding scheme that separates the threshold into two parts: (1) a spectral domain threshold that accounts for errors related to sensor stability, atmospheric conditions, and data-processing variations, and (2) a spatial domain threshold associated with georectification errors. We demonstrate our method using both multispectral Landsat images and airborne imaging spectroscopy HyMap images. The results show that the spectral domain threshold gives high detection capabilities with moderate false-alarm rate. Adding the spatial domain threshold to the spectral domain threshold reduces the false-alarm rates while maintaining good detection capabilities. FundingThis study was supported by the FP7-project EO-Miners, [grant number 2442242]; Czech Science Foundation, HypSo project [grant number 205/09/1989].
On the epidemiology and etiology of pneumonia in adults. (1988)

In a group of 74 hospitalized patients with the diagnosis of acute infectious pneumonia, the etiological contribution of viral and bacterial agents is analyzed in cases of clarified etiology and an assessment is made of the relationship between the explained etiology and the overall epidemiological situation. Etiology was clarified in 36 patients (48.6%). Viral and bacterial etiology was confirmed in 13.3% and 39.8% of the entire group respectively. In three cases, mixed viral and bacterial infection was reported. Most prominent among the viral agents were herpes simplex, parainfluenza, respiratory syncytial and influenza type B viruses. As far as the bacterial agents were concerned, the species most frequently isolated were Staphylococcus aureus, Streptococcus pneumoniae and a variety of Enterobacteriaceae. The relationship between the overall epidemiological situation and pneumonia etiology is discussed as well as the relevance of the diagnostic methods employed.