gebhart/patrepeval huggingface dataset:
Abstract 334: Selective Renal Deafferentation Attenuates the Development of Genetic and Renal Hypertension (2012)

Renal denervation decreases arterial pressure (AP) in hypertensive rats and humans. This procedure destroys both afferent and efferent nerves. Several investigators have proposed that renal afferent nerves contribute to the elevated AP. We developed a procedure to selectively remove renal afferent nerves with capsaicin (1-100 mM) both topically on the nerve and in the renal pelvis. We examined the effects of renal deafferentation on the development of genetic and renal hypertension. We studied spontaneously hypertensive rats (SHR), and a model of renal hypertension, two kidney-one clip (2K1C) in Sprague-Dawley rats. SHR were treated at 3-4 weeks of age with capsaicin. Mean arterial pressure was recorded by tail cuff through 16 weeks of age. On week 17, rats were cannulated, allowed 3 days to recover then had their AP measured directly for 3 days (3 hrs/day). Rats with renal deafferentation (n=11) had lower arterial pressure weeks 9-16 (average reduction AP=10.1±1.4 mmHg, ANOVA, p=0.0049) compared to control (saline treated, n=6) although the final direct recording was not significantly different on week 17 (control AP=184.1±3.4 mmHg vs deafferented AP=173.9±4.3 mmHg, p=0.07). Substance P levels from the kidneys were reduced in deafferented rats compared to control (6.9±1.0 vs 17.3±5.2 pg/g protein, p=0.0009). In contrast, renal NE levels were not altered (307±19 vs 313±20 pg/g protein, p=0.428). In the second study, the left kidney in weanling Sprague-Dawley rats was exposed to capsaicin or saline. Rats were allowed to mature (&gt;250 g BW) then subjected to left renal artery clipping (0.2mm) or sham clip. AP was recorded by tail cuff during development of 2K1C for 6 weeks before direct cannulation to record AP on week 7. Renal deafferentation prevented the development of hypertension in 13 rats compared to 9 saline treated rats (average reduction AP=16.9±2.7 mmHg, ANOVA, p=0.0031). Saline treated rats had a higher AP 7 weeks after clipping (147.1±10.2 vs 130.5±4.2 mmHg direct recording, p=0.02). The left kidney contained 48% SP compared to the right kidney (p=0.04). These data suggest that increased afferent renal nerve activity contributes to the elevation in AP in hypertension and contributes to essential hypertension in humans. Supported by USPHS DA017371.
Family and Line Selection for Reduced Palmitate, Saturates, and Linolenate of Soybean (2001)

Development of soybean [ Glycine max (L.) Merr.] cultivars with reduced palmitate and stearate will lower the total saturated fatty ester content of the seed oil, and reduction of linolenate will improve its oxidative stability. The objective of this study was to compare the family and line methods of selection for reduced palmitate, palmitate + stearate (saturates), and linolenate in four populations segregating for the major alleles fap1 and fap3 for reduced palmitate or the fan1 (A5) and fan2 for reduced linolenate. Four random F 3 ‐derived lines from 21 F 2 families from each population were evaluated in a plant‐row‐yield test in 1995 and replicated trials at four locations in 1996. For the family method, the mean palmitate, saturates, and linolenate of the four F 3 ‐derived lines of each F 2 family was used to identify families from which to select individual lines. For the line method, lines were selected without regard to the family structure. The fatty ester contents of the selected and unselected lines based on data from one environment were compared with their mean fatty ester contents in the other environments. The number of lines selected for each of the traits by the family method was less than for the line method in all populations. There was a greater percentage of lines incorrectly rejected by the family method than by the line method. For development of cultivars with reduced palmitate, saturates, and linolenate, breeding methods that rely on family performance would not be more effective or efficient than methods that ignore family structure.
The tell-tale heart: heart rate fluctuations index objective and subjective events during a game of chess (2012)

During a decision-making process, the body changes. These somatic changes have been related to specific cognitive events and also have been postulated to assist decision-making indexing possible outcomes of different options. We used chess to analyze heart rate (HR) modulations on specific cognitive events. In a chess game, players have a limited time-budget to make about 40 moves (decisions) that can be objectively evaluated and retrospectively assigned to specific subjectively perceived events, such as setting a goal and the process to reach a known goal. We show that HR signals events: it predicts the conception of a plan, the concrete analysis of variations or the likelihood to blunder by fluctuations before to the move, and it reflects reactions, such as a blunder made by the opponent, by fluctuations subsequent to the move. Our data demonstrate that even if HR constitutes a relatively broad marker integrating a myriad of physiological variables, its dynamic is rich enough to reveal relevant episodes of inner thought.
Long-reads assembly of the Brassica napus reference genome, Darmor-bzh (2020)

Abstract Background The combination of long-reads and long-range information to produce genome assemblies is now accepted as a common standard. This strategy not only allow to access the gene catalogue of a given species but also reveals the architecture and organisation of chromosomes, including complex regions like telomeres and centromeres. The Brassica genus is not exempt and many assemblies based on long reads are now available. The reference genome for Brassica napus , Darmor-bzh, which was published in 2014, has been produced using short-reads and its contiguity was extremely low if compared to current assemblies of the Brassica genus. Findings Here, we report the new long-reads assembly of Darmor-bzh genome ( Brassica napus ) generated by combining long-reads sequencing data, optical and genetic maps. Using the PromethION device and six flowcells, we generated about 16M long-reads representing 93X coverage and more importantly 6X with reads longer than 100Kb. This ultralong-reads dataset allows us to generate one of the most contiguous and complete assembly of a Brassica genome to date (contigs N50 &gt; 10Mb). In addition, we exploited all the advantages of the nanopore technology to detect modified bases and sequence transcriptomic data using direct RNA to annotate the genome and focus on resistance genes. Conclusion Using these cutting edge technologies, and in particular by relying on all the advantages of the nanopore technology, we provide the most contiguous Brassica napus assembly, a resource that will be valuable for the Brassica community for crop improvement and will facilitate the rapid selection of agronomically important traits.
Effect of Tempering on Microstructure and Mechanical Properties of Laser Welded and Post-Weld Treated AHSS Specimens (2017)

An advanced high strength steel (0.08 %C, 1.79 %Mn, 0.23 %Si) was subjected to different post-weld heat treatments by quenching &amp; tempering treatments (Q&amp;T) after laser welding to reduce the risk of martensite formation in a few seconds based on an idea of quench and partitioning (Q&amp;P), mechanism. The thermal stability of retained austenite, microstructure development and mechanical properties have been studied at 2 tempering temperatures of 440°C (Ms) and 636°C (Bs), both for 15 minutes, by means of electron microscopy, dilatometry, hardness profile and tensile tests. Dilatometer study unveiled that redistribution of carbon atoms and precipitation of transition carbides occur around 150°C and austenite decomposition occur at 600°C. Tempering at 636°C resulted in notable effect on the mechanical properties, while no significant difference was detected at 440°C, except a slight hardness drop. The strength increased up to 12% for the different specimens without significant loss in ductility for all specimens tempered at 636°C, which may be caused by precipitation hardening and recrystallization of martensite lath boundaries during tempering around 600°C.
Protein-4.2 association with band 3 (AE1, SLCA4) in Xenopus oocytes: effects of three natural protein-4.2 mutations associated with hemolytic anemia (2005)

We have investigated the effects of coexpression of protein 4.2 and three protein-4.2 variants with band 3 in the Xenopus oocyte expression system. Normal protein 4.2 increased band-3-specific chloride transport in the oocytes. Protein 4.2 also coimmunoprecipitated with band 3 and colocalized with band 3 at the oocyte plasma membrane. The increase in band-3-mediated chloride transport and coimmunoprecipitation of protein 4.2 required the presence of the N-terminal cytoplasmic domain of band 3. Protein 4.2 also localized to the oocyte plasma membrane in the absence of band 3. The protein-4.2 variants 4.2 Tozeur (R310Q) and 4.2 Komatsu (D175Y) had impaired ability to bind to band 3 and these variants did not localize to the oocyte plasma membrane when expressed on their own or when coexpressed with band 3. Unexpectedly, 4.2 Nippon (A142T) behaved similarly to normal protein 4.2. In the absence of a crystal structure of protein 4.2, we propose a homology model of protein 4.2 based on the structure of the sequence-related protein transglutaminase. Using our results in oocytes and this homology model we speculate how these mutations affect protein 4.2 and result in hereditary spherocytosis.
Application of Doppler beam sharpening for azimuth refinement in prospective low‐THz automotive radars (2018)

In this study, the authors investigate the application of the Doppler beam sharpening (DBS) technique for angular refinement to the emerging area of low‐terahertz (THz) radar sensing. Ultimately this is to improve radar image quality in the azimuth plane to complement the excellent range resolution and thus improve object classification in low‐THz radar imaging systems for autonomous platforms. The study explains the fundamental theory behind the process of DBS and describes the applicability of DBS to automotive sensing, indicating the potential for synthetic beamwidths of a fraction of a degree. Low‐THz DBS was experimentally tested under controlled laboratory conditions, not only to accurately localised target objects in Cartesian space but also to provide unique object imaging at low‐THz frequencies with wide azimuthal beamwidth antennas. It was shown that a stationary (i.e. non‐scanned) wide beam antenna mounted on a moving platform can deliver imagery at least comparable to that produced by physical beamforming, be that steering arrays or narrow beam scanning antennas as in the experimental case presented.
Cu3(HHTP)2 c‐MOF/ZnO Ultrafast Ultraviolet Photodetector for Wearable Optoelectronics (2022)

Two-dimensional conductive metal-organic frameworks (2D c-MOFs) are a family of highly tunable and electrically conducting materials that can be utilized in optoelectronics. A major issue of 2D c-MOFs for photodetection is their poor charge separation and recombination dynamics upon illumination. This study demonstrates a Cu<sub>3</sub> (HHTP)<sub>2</sub> /ZnO type-II heterojunction ultraviolet (UV) photodetector fabricated by layer-by-layer (LbL) deposition, in which the charge separation of photogenerated carriers is enhanced. At optimized MOF layer cycles, the device achieves a responsivity of 78.2 A/W and detectivity of 3.8×10<sup>9</sup> Jones at 1 V. Particularly, the device can be operated in the self-powered mode with an ultrafast response time of 70 μs, which is the record value for MOF-based photodetectors. In addition, even after 1000-time bending of 180°, the flexible device maintains stable performance. This flexible MOF-based UV photodetector with anti-fatigue and anti-bending properties provides strong implication to wearable optoelectronics.
Enantioselective Total Synthesis of Avarol and Avarone (1999)

Formation of the C11-C1' bond through application of Barton's radical decarboxylation and quinone addition is the cornerstone of a new convergent and concise synthesis of the marine metabolites avarol (1) and avarone (2; see scheme), for which antimitotic, antileukemic, and antiviral effects have been reported.
Appropriate and Background Affect in Facial Displays of Emotion (1976)

The hypothesis that normal subjects can express emotions more accurately than schizophrenics was tested by having judges match photographs of five posed affects with five emotion words for each of 16 normal and 16 schizophrenic male expressors. Discrimination accuracy was high, but the hypothesis was not confirmed. The results of a second study, in which separate measures of appropriate (intended) and "background" affect (eg, the rated intensity of anger displayed in a subject's nonangry poses) were provided, supported our expectation that discrimination accuracy is a function of both appropriate and background affect. The normal men tended to display more appropriate affect generally, and displayed more background happiness, while the schizophrenics expressed more background anger, sadness, and fear. Both intended and background affect, therefore, must be carefully considered in studies of emotional expressions.
FCGR2A/CD32AandFCGR3A/CD16AVariants and EULAR Response to Tumor Necrosis Factor-α Blockers in Psoriatic Arthritis: A Longitudinal Study with 6 Months of Followup (2012)

Our data indicate that FCGR2A polymorphism may influence the response to TNF-α blockers (namely etanercept) in PsA in a direction opposite to that previously found in patients with rheumatoid arthritis.
American society for apheresis white paper: Considerations for medical staff apheresis medicine physician credentialing and privileging (2012)

Patient safety during therapeutic apheresis involves both practitioners' and institutional provision of care aspects. Physician training experiences, medical licensing, and board certification status, along with continuing medical education and participation in risk management/patient safety projects are characteristic facets of physician competency in the provision of quality apheresis medicine interventions. Documentation of such indicators may help in medical staff deliberations regarding physician privileging in the oversight and management of apheresis medicine activities in hospitals.
Automated alignment of 2D serial images for 3D reconstruction of biological structures (2004)

To characterize the complex genetics of mammalian brain architecture, researchers have long used mouse models that mimic specific human maladies to decipher the causes of the disease and to test new drugs and treatments. One of growing interests is to use imaging and computer vision methods for so-called neuroinformatics and neurocartography. In this paper, we propose a novel knowledge-based approach for the alignment of 2D serial images of the mouse brain, thereby allowing 3D reconstruction of functional or anatomical cerebral structures in a mouse brain by forming 3D stacks of 2D serial histological sections. In our implementation, heuristic rules supplied by human experts are implemented by use of fuzzy logics. Our results suggest that accurate alignment can be achieved in an automated manner despite the input images are not completely identical in structure.
Amorphous Memories and Bistable Switches (1972)

The two types of switching phenomena that characterize thin films of covalent amorphous solids are described in detail. Several mechanisms that can account for these phenomena are presented and analyzed in view of recent experimental data. Two applications of bistable switching to computer memories are discussed—the electronically alterable Read-Mostly Memory (RMM) and the mass optical memory (MOM).
Crowd Physics: Studies of Collaborative Opportunities in Spatiotemporal Networks of People (2014)

Understanding & Shaping Collaborative Systems Studies of crowd physics for sensing & acting in world Design, optimization of collaborative substrate Rich area, multiple directions for enhancing collaboration Opportunities include new approaches to epidemiology, e.g., where reachability & efficiency are minimized
A dual-poly (n+/p+) gate, Ti-salicide, double-metal technology for submicron CMOS ASIC and logic applications (1989)

The process architecture and device characteristics of a submicrometer CMOS n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> /p <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> poly gate, Ti-salicide, double-metal technology are described. Tradeoffs among circuit shrinkability, device gain, and hot-carrier-injection susceptibility are discussed. This technology has been successfully implemented in a 0.8-μm unified-design-rule high-performance high-end MPU product
Activation of the Dorsal Premotor Cortex and Pre-Supplementary Motor Area of Humans During an Auditory Conditional Motor Task (2000)

Using functional magnetic resonance imaging (fMRI), we measured regional blood flow to examine which motor areas of the human cerebral cortex are preferentially involved in an auditory conditional motor behavior. As a conditional motor task, randomly selected 330 or 660 Hz tones were presented to the subjects every 1. 0 s. The low and high tones indicated that the subjects should initiate three successive opposition movements by tapping together the right thumb and index finger or the right thumb and little finger, respectively. As a control task, the same subjects were asked to alternate the two opposition movements, in response to randomly selected tones that were presented at the same frequencies. Between the two tasks, MRI images were also scanned in the resting state while the tones were presented in the same way. Comparing the images during each of the two tasks with images during the resting state, it was observed that several frontal motor areas, including the primary motor cortex, dorsal premotor cortex (PMd), supplementary motor area (SMA), and pre-SMA, were activated. However, preferential activation during the conditional motor task was observed only in the PMd and pre-SMA of the subjects' left (contralateral) frontal cortex. The PMd has been thought to play an important role in transforming conditional as well as spatial visual cues into corresponding motor responses, but our results suggest that the PMd along with the pre-SMA are the sites where more general and extensive sensorimotor integration takes place.
The RNA polymerase II elongation complex (1995)

The initiation stage of transcription by RNA polymerase II has long been regarded as the primary site for regulation of eukaryotic gene expression. Nevertheless, a growing body of evidence reveals that the RNA polymerase II elongation complex is also a major target for regulation. Biochemical studies are implicating an increasing number of transcription factors in the regulation of elongation, and these transcription factors are being found to function by a diverse collection of mechanisms. Moreover, unexpected features of the structure and catalytic mechanism of RNA polymerase II are forcing a reconsideration of long-held views on the mechanics of some of the most basic aspects of polymerase function. In this review, we will describe recent insights into the structures and functions of RNA polymerase II and the transcription factors that control its activity during the elongation stage of eukaryotic messenger RNA synthesis.
Interleukin (IL)‐4 and to a lesser extent either IL‐13 or interferon‐gamma regulate the production of eotaxin‐2/CCL24 in nasal polyps (2003)

All together these findings suggest that Th1 and Th2 cytokines may regulate eotaxin-2/CCL24 production in nasal polyps and nonallergic rhinits.
Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2 (2017)

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease caused by CAG repeat expansion in the ATXN2 gene. The repeat resides in an encoded region of the gene resulting in polyglutamine (polyQ) expansion which has been assumed to result in gain of function, predominantly, for the ATXN2 protein. We evaluated temporal cerebellar expression profiles by RNA sequencing of ATXN2Q127 mice versus wild-type (WT) littermates. ATXN2Q127 mice are characterized by a progressive motor phenotype onset, and have progressive cerebellar molecular and neurophysiological (Purkinje cell firing frequency) phenotypes. Our analysis revealed previously uncharacterized early and progressive abnormal patterning of cerebellar gene expression. Weighted Gene Coexpression Network Analysis revealed four gene modules that were significantly correlated with disease status, composed primarily of genes associated with GTPase signaling, calcium signaling and cell death. Of these genes, few overlapped with differentially expressed cerebellar genes that we identified in Atxn2-/- knockout mice versus WT littermates, suggesting that loss-of-function is not a significant component of disease pathology. We conclude that SCA2 is a disease characterized by gain of function for ATXN2.
Cathode sheath subjected to a voltage step: applications to sheath width measurement (1994)

We present the current and voltage dynamics of a cathode sheath when a fast downward step of negative voltage is superimposed on the constant cathode bias. Owing to the very different reaction times of electrons and ions, the early interval of the dynamic can be used to measure the stationary cathode sheath width. The method is applied to an abnormal glow discharge in oxygen.
Nuovi Approcci Terapeutici contro il Cancro del Colon (2004)

This presentation was given in Augusta (Siracusa, Italy) for the 2004 Paul Harris Fellow Award, Rotary Foundation of Rotary International. The lecture discusses the clinical significance of the GC-C pathway and its potential as a therapeutic target for colon cancer and metastatic tumors. It underscores the importance of the dysregulation of the GC-C pathway in promoting colorectal tumorigenesis and of dietary calcium in the GC-C-mediated chemoprevention. Questa e’ la presentazione per il Premio 2004 Paul Harris Fellow del Rotary International (Augusta, Siracusa, Italia). La dissertazione illustra l’importante significato clinico della via moleculare regulata da GC-C e dai suoi ligandi (guanilina, uroguanilina ed ST) per la prevenzione e cura del cancro del coloretto.
Effect of water fogs on the deliberate ignition of hydrogen. Final report (1982)

This report presents an experimental evaluation of the effects of water fog density, droplet diameter, and temperature on the lower flammable limit (LFL) of hydrogen-air-steam mixtures. The results show that the LFL for hydrogen in air at 20/sup 0/C is only marginally higher with fog than without. Most of the nozzles tested at 20/sup 0/C raised the hydrogen LFL from 4.0 vol % to about 4.8%, for the case of dense fogs with volume-average drop size in the range 45 to 90 microns. The lower flammable limit at 50/sup 0/C was typically 7.2% for dense fogs with drop size in the range 25 to 50 microns. The lower flammable limit at 70/sup 0/C was typically 7.6%. Typical fog concentrations ranged from 0.03 to 0.09 vol % at 20/sup 0/C and decreased with increasing fog temperature. 7 figures, 4 tables.
Comparative mitogenomic analyses of three scallops (Bivalvia: Pectinidae) reveal high level variation of genomic organization and a diversity of transfer RNA gene sets (2009)

Comparative mitogenomic analyses among three species from the subfamily Chlamydinae show that the three genomes exhibit a high level of genomic variation and a diversity of tRNA gene sets, characterized by extensive translocation of genes. These features provide useful clues and information for evolutionary analysis of scallop mitogenomes.