gebhart/patrepeval huggingface dataset:
Supplementary Figures 1-2 from The Lysine 831 of Vascular Endothelial Growth Factor Receptor 1 Is a Novel Target of Methylation by SMYD3 (2023)

Supplementary Figures 1-2 from The Lysine 831 of Vascular Endothelial Growth Factor Receptor 1 Is a Novel Target of Methylation by SMYD3
The Use of Semifluorinated Alkanes in Blood-Substitutes (1993)

Semifluorinated alkanes are useful for blood-substitutes in two different ways: as co-surfactant to stabilize emulsions with perfluorocarbons as oxygen-carrier and as oxygen-carrier instead of perfluorocarbons. Semifluorinated alkanes act as co-surfactants in low concentrations because they are enriched at the interface perfluorodecalin/water. Emulsions with semifluorinated alkanes dissolve about the same amount of oxygen as emulsions with perfluorocarbons. The stability of these emulsions depends on the nature of the alkyl and the perfluoroalkyl chain. Semifluorinated alkanes do not eliminate hydrogen fluoride under clean-up conditions of perfluorocarbons. According to toxicity tests against human carcinoma cells semifluorinated alkanes with alkyl chains are harmless in the examined range from C6 to C10.
Influence of speerm processing on IVP of bovine embryos. (2012)

Made available in DSpace on 2012-10-17T01:04:29Z (GMT). No. of bitstreams: 1\nDigitalizar0024.pdf: 615005 bytes, checksum: 0f29bff4b9ad7c34fec06664b83c076d (MD5)\n Previous issue date: 2012-10-08
Facile and Green Preparation of High UV-Blocking Lignin/Titanium Dioxide Nanocomposites for Developing Natural Sunscreens (2018)

Lignosulfonate (LS), one type of industrial lignin and natural macromolecular sun blocker, was applied to modify TiO2 via one-pot hydrothermal esterification. The reaction mechanism and composite structure of LS@TiO2 were investigated by DLS, TEM, AFM, TG, UV, FTIR, XPS, XRD, ESR, and contact angle measurements. The results show that the esterification modification occurred between the carboxyl groups of lignin and the hydroxyl groups on the surface of TiO2. Lignosulfonate of 3.4 wt % with a thickness of 13 nm effectively coated the normal TiO2, and the LS@TiO2 composites were nanoscale with an average size of 119 nm. Hydroxylated TiO2 particles were more reactive, and the contents of LS on TiO2 were processed by 0.1 and 1 M HCl and increased to 5.0 wt % (LS@TiO2-0.1M) and 6.0 wt % (LS@TiO2-1M), respectively. Chemically coated LS not only improved the dispersibility of TiO2 in the substrates, but also significantly boosted its UV-blocking ability. Therefore, TiO2@LS nanocomposites were applied as the sole active in the pure cream and the sunscreen performance was compared with that of TiO2. The sun protection factor (SPF) values of creams containing 5, 10, and 20 wt % LS@TiO2 were 16, 26, and 48, respectively. They were 30–60% higher than those of the creams containing the same amount of TiO2. The sunscreen performance of LS@TiO2 improved with LS content. The SPF value of pure cream containing 10 wt % LS@TiO2-1M reached 50+. The possible UV-blocking enhancement mechanism of LS@TiO2 was also revealed. Preparation of LS@TiO2 nanocomposites provides a facile and green way for value-added utilization of lignin biomass and highly efficient UV-blocking of nano-TiO2 materials.
New Service Model for Common Mental Disorders in Hong Kong: a Retrospective Outcome Study (2019)

The first 8-month outcome of the new service model was encouraging, with shortened waiting time, reduced severity of symptoms, and better exit status (high recovery and step-down rates).
Laser intensity stabilization with a liquid crystal variable retarder for a nuclear magnetic resonance gyroscope prototype (2015)

The laser intensity stability counts for the performance of Nuclear Magnetic Resonance Gyroscope (NMRG). We switch to attenuate the fluctuation of laser intensity with the aid of an opto-electric modulator and feedback control. The Liquid Crystal Variable Retarder (LCVR) has a sharp edge over its counterparts such as AOM and EOM benefiting from its compact size, low operation voltage and large clear aperture. In this paper, we demonstrate a LCVR based laser intensity stabilization system designed for a NMRG prototype. The setup mainly compromises of two crossed linear polarizers, a LCVR, a polarized beam splitter, a photo detector and a digital servo control unit. The intensity of a small portion of laser split by the PBS is detected by the photodiode and then fed into the servo control unit. It compares the current laser intensity with the setpoint value, generates a proper control signal under the supervision of the built-in algorithm and drives the LCVR to change the incident laser polarization state, and hence the output laser intensity. In addition, we derive the formula of the relative output laser intensity with voltage, which helps to design the control algorithm. Finally, the long-term stability of the system reaches 0.038% in a 4-hour continuous measurement.
You Are Your Check-In (2014)

Currently the use of location-based social networks are becoming quite popular. For example, Foursquare reported 50 million users in 2014. Data from this type of system can be viewed as a source of sensing, in which the sensors are users with their mobile devices sharing data on various aspects of the city. This source of data enables large-scale study of urban social behavior and city dynamics. In this paper we show how we can use the signals emitted by Foursquare users to better understand the differences between the behavior of tourists and residents. We analyze tourists and residents in four popular cities around the world: London, New York, Rio de Janeiro and Tokyo. One of the contributions of this work is the spatio-temporal study of properties of the behavior of these two classes of users (tourists and residents). We have identified, for example, that some locations have features that are more correlated with the tourists' behavior, and also that even in places frequented by tourists as well as residents there are clear differences in the patterns of behavior of these classes. Our results could be useful in several cases, for example, to help in the development of new recommendation systems specific for tourists.
Resting hemodynamics after total versus standard orthotopic heart transplantation in patients with high preoperative pulmonary vascular resistance (1997)

Total orthotopic heart transplantation improves cardiac output and index in pts with high preoperative pulmonary vacular resistance. There is a lower mean RA and PA pressure perhaps due to less tricuspid and mitral regurgitation. In view of the frequently observed restrictive filling pattern after cardiac transplantation, total orthotopic heart transplantation can be beneficial until this pattern has subsided by preserving atrioventricular synchrony and offering better atrial transport.
Results and insights from the N Reactor Level II/III PRA (probabilistic risk assessment) for application to advanced reactor designs (1990)

A Level II/III probabilistic risk assessment has been performed for N Reactor, a US Department of Energy production reactor. State-of-the-art methodology was employed based on methods developed by Sandia for the US Nuclear Regulatory Commission for the NUREG-1150 study. Latin Hypercube sampling techniques were used to develop uncertainty distributions for the risks associated with postulated core damage events initiated by fire, seismic and internal events as well as the overall combined risk. The results show the risks from N Reactor to be small. Systematic, procedural and phenomenological insights and their significance to future reactor designs are discussed. A key insight is that active systems can inadvertently interfere with passive systems unless proper design precautions are taken. 7 refs., 2 tabs.
Reducing cross domain call overhead using batched futures (1994)

In many systems such as operating systems and databases it is important to run client code in a separate protection domain so that it cannot interfere with correct operation of the system. Clients communicate with the server by making cross domain calls, but these are expensive, often costing substantially more than running the call itself. This paper describes a new mechanism called batched futures that transparently batches possibly interrelated client calls. Batching makes domain crossings happen less often, thus substantially reducing the cost. We describe how the mechanism is implemented for the Thor object-oriented database system, and presents performance results showing the benefit of the mechanism on various benchmarks.
Linear motion system cable elimination via multiphase capacitive power transfer through sliding journal bearings (2017)

Electrical loads that slide on moving gantries or rails are common in industry and automation, e.g. assembly lines, spindle heads, x-y tables, etc. These systems often use insulated linear bearings to support mechanical movement during the intended process and a flexible wire-way or cable track provides an electrical connection to power moving parts. This paper proposes eliminating the cable connection by using the capacitance of the linear bearings to transfer power between stationary and moving parts, i.e. the bearings/rails form the coupling of a capacitive power transfer system. This is enabled by a 3-5 MHz, 3 phase, resonant inverter capable of driving AC current through the bearing-rail capacitance where it is ultimately rectified on a carriage for final use. The high switching frequency enables smaller bearing coupling capacitance to be used with lower developed voltages. The inverter uses 650V Gallium Nitride (GaN) High Electron Mobility Transistors (HEMTs) in a 3 phase configuration to extend switching frequencies to multi-MHz, thus enabling power transfer levels towards 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> -10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> watt levels. The brushless and wireless excitation of a sliding electrical load, using linear plain bearings sliding on conventional 1 inch diameter anodized shafting serves as a demonstration application. Experimental tests at 3.66 MHz demonstrate 111.9W power transfer to a sliding carriage load.
Natural terrain classification using three‐dimensional ladar data for ground robot mobility (2006)

Abstract In recent years, much progress has been made in outdoor autonomous navigation. However, safe navigation is still a daunting challenge in terrain containing vegetation. In this paper, we focus on the segmentation of ladar data into three classes using local threedimensional point cloud statistics. The classes are: “scatter” to represent porous volumes such as grass and tree canopy; “linear” to capture thin objects like wires or tree branches, and finally “surface” to capture solid objects like ground surface, rocks, or large trunks. We present the details of the proposed method, and the modifications we made to implement it on‐board an autonomous ground vehicle for real‐time data processing. Finally,we present results produced from different stationary laser sensors and from field tests using an unmanned ground vehicle. © 2006 Wiley Periodicals, Inc.
Formal Synthesis of (–)-Siccanin Using an Enantioselective Domino Wacker/Carbonylation/Methoxylation Reaction (2015)

A formal synthesis of (–)-siccanin was achieved through an enantioselective domino Wacker/carbonylation/methoxylation reaction as the key step to form the chroman ring with a quaternary stereogenic center with 95% ee. The pendant cyclohexyl moiety was introduced through a two-step aldol condensation.
4D attenuation map generation in PET/MR imaging using 4D PET derived motion fields (2013)

Respiratory motion can potentially reduce accuracy in functional and anatomical images fusion from combined PET/MR systems. Methodologies for the correction of respiratory motion in PET acquisitions in combined PET/MR systems are almost exclusively based on the use of respiratory synchronized MRI acquisitions to derive motion fields. The acquisition of 4D MR datasets is however associated with a compromise between image quality and acquisition duration limiting its use in clinical practice. The objective of this work was therefore to generate 4D MR images and associated attenuation maps from a single static MR image and motion fields obtained from simultaneously acquired 4D non-attenuation corrected (NAC) PET images. 4D PET/MRI datasets were acquired for five patients on the SIEMENS mMR PET/MR system. The 4D PET acquired datasets were retrospectively binned into 4 motion amplitude frames corresponding to the simultaneously acquired 4D gradient echo MR images. A single MR Dixon scan was also acquired at end of expiration for PET AC purposes. All the reconstructed 4D NAC PET images were then registered using an elastic registration algorithm to the single `end of expiration' NAC PET image. The derived motion fields were subsequently applied to the `end expiration' 3D gradient echo MR volume and its corresponding attenuation map to generate respiratory synchronized MR images and corresponding attenuation maps. The accuracy of the proposed method was assessed by comparing the generated to the original images. Good diaphragm profile matching, high correlation coefficients (0.91± 0.03) and small errors (<;3mm) were noticed between the generated and acquired 4D MRI series. Moreover, small classification errors between the generated and 4D MR extracted attenuation maps. As a conclusion, these results may allow for accurate PET AC and respiratory motion correction in PET/MR, without the need for patient specific 4D MR acquisitions.
Structural Study of an Al72Ni20Co8Decagonal Quasicrystal Using the High-Angle Annular Dark-Field Method (1997)

High-angle annular dark-field (HAADF) images of an Al 72 Ni 20 Co 8 decagonal quasicrystal have been taken for the first time. It has been found that the transition metals form pentagonal and star-shaped cluster columns with radii of about 0.4 nm. The atom-cluster columns with a 2 nm diameter of the alloy, which have been considered as the basic structural unit with decagonal symmetry so far, have been revealed to have no decagonal symmetry. These atom-cluster columns have been found to be decomposed into the pentagonal and star-shaped cluster columns, corresponding clusters existing in the Al 13 Fe 4 monoclinic approximant. The tiling of the pentagonal and star-shaped clusters has been found to agree with the rhombic Penrose lattice for an area with a diameter greater than 50 nm.
Laser Speckle Contrast Imaging of a Rotational Full-Thickness Lower Eyelid Flap Shows Satisfactory Blood Perfusion (2020)

Full-thickness eyelid flaps from the lower eyelid are frequently used to repair larger upper eyelid defects. Perfusion monitoring has recently been implemented in several reconstructive surgical procedures, however, perfusion monitoring of a rotational eyelid flap has not yet been described. The authors' employed laser speckle contrast imaging to monitor blood perfusion in a rotational flap from the lower eyelid, used to cover a large tumor defect in the upper eyelid. Perfusion in the flap decreased by only 50% during surgery and was almost completely restored 5 weeks later at flap division (91%). The excellent surgical outcome in the present case is deemed to be the result of satisfactory blood perfusion of the flap.
Use of Two Endoxylanases with Different Substrate Selectivity for Understanding Arabinoxylan Functionality in Wheat Flour Breadmaking (2001)

ABSTRACT A Bacillus subtilis endoxylanase (XBS) with a strong selectivity for hydrolysis of water‐unextractable arabinoxylan (WU‐AX) and an Aspergillus aculeatus endoxylanase (XAA) with a strong selectivity for hydrolysis of water‐extractable arabinoxylan (WE‐AX) were used in straight‐dough breadmaking with two European wheat flours. Dough, fermented dough, and bread characteristics with different levels of enzyme addition were evaluated with a strong emphasis on the arabinoxylan (AX) population. The WU‐AX solubilized by XBS during breadmaking were mainly released during mixing and had higher molecular weight, in contrast to their counterparts solubilized by XAA, which were mainly released during fermentation and had lower molecular weight. This coincided with increased loaf volume with XBS and a negative to positive loaf volume response with XAA. Bread firmness and dough extract viscosity also were affected by endoxylanase addition. Results confirmed that WU‐AX are detrimental for breadmaking, while WE‐AX and solubilized AX with medium to high molecular weight have a positive impact on loaf volume.
What do patients think about palliative care? A national survey of hematopoietic stem cell transplant recipients (2023)

Palliative care (PC) benefits patients undergoing hematopoietic stem cell transplantation (HSCT), but it remains underutilized. Although transplant physicians report concerns regarding how patients perceive PC, HSCT recipients' perceptions about PC remain unaddressed. We conducted a multisite, cross-sectional survey of autologous and allogeneic HSCT recipients 3 to 12 months after transplant to assess their familiarity, knowledge, and perception of PC, as well as their unmet PC needs. We computed a composite score of patients' perceptions of PC and used a generalized linear regression model to examine factors associated with these perceptions. We enrolled 69.6% (250/359) of potential participants (median age = 58.1; 63.1% autologous HSCT). Overall, 44.3.8% (109/249) reported limited knowledge about PC and 52% (127/245) endorsed familiarity with PC. Most patients felt hopeful (54%) and reassured (50%) when they heard the term PC; 83% saw referral as a sign their doctor cared about what was happening to them. In multivariate analyses, patients who were more knowledgeable about PC were more likely to have positive perceptions of PC (B = 7.54, standard error = 1.61, P < .001). Patients' demographics, HSCT features, quality of life, and symptom burden were not significantly associated with perceptions of PC. HSCT recipients have positive perceptions of PC, though many have limited knowledge about its role. Patients who were more knowledgeable about PC were more likely to have positive perceptions of PC. These data do not support transplant physicians' negative concerns about how patients perceive PC and underscore the need to further educate patients and transplant physicians about PC.
SimDialog: A visual game dialog editor (2008)

SimDialog is a visual editor for dialog in computer games. This paper presents the design of SimDialog, illustrating how script writers and non-programmers can easily create dialog for video games with complex branching structures and dynamic response characteristics. The system creates dialog as a directed graph. This allows for play using the dialog with a state-based cause and effect system that controls selection of non-player character responses and can provide a basic scoring mechanism for games.
A sulfonated polybenzophenone/polyimide copolymer as a novel proton exchange membrane (2015)

A sulfonated polybenzophenone/polyimide block copolymer membrane exhibited high proton conductivity, good dimensional and mechanical stabilities, and low gas permeability, which are attractive for fuel cell applications.
Nonsurgically induced disuse muscle atrophy and neuromuscular dysfunction upregulates alpha7 acetylcholine receptors (2013)

Previous models of muscle disuse have invariably used surgical methods that require the repetitive application of plaster casts. A method of disuse atrophy that does not require such repetitive applications is described herein. Modified plastic pipette tubing was applied to a single hindlimb (mouse), from thigh to foot, resulting in immobilization of the knee in the extension position, and the ankle in the plantar flexion position. This method resulted in the loss of soleus muscle to 11%, 22%, 39%, and 45% of its original mass at 3, 7, 14, and 21 days, respectively, in association with a significant decrease of tibialis twitch (25%) and tetanic tensions (26%) at 21 days, compared with the contralateral side and (or) sham-immobilized controls. Immunohistochemical analysis of the soleus using fluorescent α-bungarotoxin revealed a significant increase in the number of synapses per unit area (818 + 31 compared with 433 + 16/mm(2)) and an increase in muscle fibers per unit area (117 compared with 83/mm(2)), most likely related to the atrophy of muscle fibers bringing synapses closer. A 3-fold increase in alpha7 acetylcholine receptor (α7AChR) protein expression, along with increased expression of α1AChR subunit in the immobilized side compared with the contralateral side was observed. The physiology and pharmacology of the novel finding of upregulation of α7AChRs with disuse requires further study.
Defining the role of palliative radiotherapy in bone metastasis from primary liver cancer: An analysis of survival and treatment efficacy (2011)

Aims and background Primary liver cancer is the fourth leading cause of cancer-related death worldwide and is still associated with a poor prognosis. Hepatocellular carcinoma and cholangiocarcinoma are known to cause bone metastasis resulting in pain, neurologic impairment and risk of fracture. Palliative radiotherapy is the treatment of choice in symptomatic bone lesions and is usually performed as percutaneous fractionated radiotherapy. Methods and study design From June 1987 to December 2009, 41 patients (median age, 64 years) with bone metastasis received radiotherapy in our department. The analyzed patients were treated for 67 sites of bone lesions. We analyzed the applied fractionation schedules and the preferred sites of metastasis and symptoms, evaluated the therapeutic outcome in terms of symptomatic improvement, and described the prognosis of these patients. Results Main indication for palliative radiotherapy was pain in 94% of all cases. Most frequent radiation protocols were 10 × 3 Gy (20 patients) and 20 × 2 Gy (19 patients). Median applied overall dose was 39 Gy (range, 4–48 Gy) and median single dose was 2.5 Gy (range, 1.8–4 Gy). The median duration of the radiotherapeutic treatment was 15 days (range, 2–24 days) and in 12 cases treatment was discontinuated. The overall response rate to palliative radiotherapy in bone metastasis was 77%. Median overall survival in both cholangiocarcinoma and hepatocellular carcinoma patients was 4.2 months after initiation of radiotherapy (range, 0.2–38.9). Conclusions Considering the poor prognosis of patients with bone metastasis in hepatocellular carcinoma and cholangiocarcinoma, with a poor median survival of 3.7–5.0 months according to our study and existing literature, shorter radiotherapy schedules or even single-fraction irradiation can be considered.
A first-passage algorithm for the hydrodynamic friction and diffusion-limited reaction rate of macromolecules (1997)

Many important properties of a macromolecule can be expressed in terms of averages over the trajectories of diffusing particles that begin in the medium surrounding the molecule and terminate at its surface. These properties include its translational hydrodynamic friction coefficient and the Smoluchowski rate constant for diffusion-limited reactions. In this paper we introduce a first-passage algorithm (FPA) for calculating such quantities. This algorithm uses certain exact Green’s functions, or propagators, for the Laplace equation to eliminate the need to construct explicitly those portions of a diffusing particle’s trajectory that are not near an absorbing object. The algorithm is especially efficient for studying objects that contain large voids or have very irregular surfaces, such as macromolecules. Diffusion algorithms were previously shown to give accurate results for the quantities we study. In this paper, we show that first-passage methods make these algorithms more accurate and efficient. In future work, we expect to present systematic results for the properties of globular proteins.