gebhart/patrepeval huggingface dataset:
Effects of Infrared Light on Release of NO and SO in Osteoblasts (2009)

Hypoxia surrounds bone fractures as a result of interruption of the intact vasculature. Nitric Oxide (NO) and superoxide (SO) are important signaling molecules in bone formation. Our previous studies showed infrared (IR) light increases osteoblast (OB) proliferation. We hypothesize that the application of IR light alters OB mediators after hypoxia (hyp). We tested this by determining the hyp tolerance of OBs. MC3T3‐E1 cells were exposed to different durations of hyp in a 1% oxygen tension chamber (1h, 2h, 4h, 6h, 8h, 10h, 18h). Media was tested for LDH release. OBs were exposed to IR light (830nm, 4J/cm2) following 6h hyp insult. Measurements of NO and SO using DAF‐DA and DHE, respectively, followed. Fluorescence intensity was analyzed using confocal microscopy. Protein expression of HIF1α and VEGF was determined using immunohistochemistry. 4h hyp cells without glucose showed significant differences of LDH release compared to all other groups. Differences peaked at 8 h. NO and SO levels from cells not exposed to NIR light, were increased after hyp as compared to those of control. Intensity levels of cells exposed to IR were increased for both hyp and control conditions, as compared to those not exposed to the light. HIF 1α and VEGF expression were up in hypoxia and reduced after IR exposure. IR light might be clinically relevant in enhancing the rate or extent of fracture healing.
Degradation products of insulin generated by hepatocytes and by insulin protease. (1988)

The enzymatic mechanisms for insulin breakdown by hepatocytes have not been established, nor have the degradation products been identified. Several lines of evidence have suggested that the enzyme insulin protease is involved in insulin degradation by hepatocytes. To identify the products of insulin generated by insulin protease and to compare them with those produced by hepatocytes, we have incubated insulin specifically iodinated at either the B-16 or the B-26 tyrosines with insulin protease and with isolated hepatocytes, separated the products on high performance liquid chromatography (HPLC), and identified the B-chain cleavages. Insulin-sized products were obtained by Sephadex G-50 filtration. These insulin-sized products were injected on reverse-phase HPLC, and the peaks of radioactivity were identified. The product patterns generated by the enzyme and by hepatocytes were essentially identical with both isomers. The products were also sulfitolized to prepare the S-sulfonate derivatives of the B-chain and B-chain peptides. Again, the patterns on HPLC generated by the enzyme and by hepatocytes with both isomers were identical. Each of the original product peaks was also sulfitolized and injected separately on HPLC to relate B-chain peptides with product peaks. Again, the peptide compositions of the product peaks for both enzyme and hepatocytes were essentially identical. To identify the cleavage sites in the B-chain of insulin produced by insulin protease, the peptides from the degradation of [125I]iodo(B-26)insulin were purified and submitted to automated Edman degradation to identify the cycle in which radioactivity appeared. Seven peptides with cleavages on the amino side of the B26 residue were identified, and the cleavage sites were determined. Cleavages were found between B-9 and B-10 (Ser-His), B-10 and B-11 (His-Leu), B-14 and B-15 (Ala-Leu), B-13 and B-14 (Glu-Ala), B-16 and B-17 (Tyr-Leu), B-24 and B-25 (Phe-Phe), and B-25 and B-26 (Phe-Tyr). Peptides were also isolated from [125I]iodoinsulin incubated with isolated hepatocytes, and the cleavage sites in several of these were determined. These agreed exactly with the cleavage sites identified generated by the enzyme. The major peptides generated by the degradation of [125I]iodo(B-16)insulin were also isolated and sequenced, again showing identical cleavage sites.(ABSTRACT TRUNCATED AT 400 WORDS)
Selective Laser Melting and Direct Metal Deposition: From process fundamentals towards advanced products (2014)

Selective Laser Melting (SLM) is a powder-based and laser assisted additive manufacturing technology capable to produce parts layer-by-layer from a 3D CAD model. Nowadays SLM is used in various industrial domains including aerospace, automotive, electronic, chemical and biomedical, as well as other high-tech areas. Industrial interest is focussed on manufacturing of fully functional objects with high geometrical complexity and excellent mechanical properties. Properties of the manufactured parts depend strongly on each single laser-melted track and each single layer, as well as the strength of the connections between them.
Airborne Thermal Video Radiometry and Excavation Planning at Tel Leviah, Golan Heights, Israel (1999)

Eyal Ben-Dor, Juval Portugali, Moshe Kochavi, Michal Shimoni, Lipaz Vinitzky, Airborne Thermal Video Radiometry and Excavation Planning at Tel Leviah, Golan Heights, Israel, Journal of Field Archaeology, Vol. 26, No. 2 (Summer, 1999), pp. 117-127
Digital papillary adenocarcinoma: a case review (2019)

Digital papillary adenocarcinoma (DPAca) is a rare eccrine sweat gland tumor that typically presents on the upper extremities and can evade correct diagnosis and treatment because of its benign appearance. Treatment for lesions of the distal digits requires amputation given the high risk of metastasis and recurrence. This paper reviews a digital papillary adenocarcinoma in a patient who was initially managed at an outside institution and required further surgery including amputation. Treatment recommendations are reviewed.
Activation and regulation of chemokines in allergic airway inflammation (1996)

Abstract Allergic airway inflammation is characterized by peribronchial eosinophil accumulation within the submucosa surrounding the airway. The initial induction of immunoglobulin E (IgE)-mediated mast cell degranulation, up-regulation of adhesion molecules, and the production of inflammatory and chemotactic cytokines, leading to the infiltration of specific leukocyte subsets, is orchestrated in a sequential manner. The activation and degranulation of local mast cell populations is an immediate airway response mediated both by antigen-specific, surface bound IgE and by cytokine-induced activational pathways. Subsequently the infiltration and activation of effector leukocytes (neutrophils and eosinophils) mediated by the persistant activation of allergen-specific T cells leads to pathological manifestations within the lung and airway. The development of appropriate animal models to dissect the critical mechanisms involved in antigen-induced airway pathology is crucial for the development of efficacious therapies. We have utilized a model of allergic airway inflammation induced by intratracheal challenge with parasite (Schistosoma mansoni) egg antigen in presensitized mice. This model has proven useful in the assessment of eosinophil recruitment and has identified key cytokines involved in leukocyte elicitation. These cytokines include interleukin-4 and tumor necrosis factor, which appear to act as early response mediators, as well as C-C chemokines, macrophage inflammatory protein-1a, and RANTES, which act directly on eosinophil recruitment. In addition, we have found that both C-X-C and C-C chemokines are expressed in pulmonary-derived mast cells, suggesting an important contribution to leukocyte responses in the allergic airway.
On Certain Equations over Finite Fields and Cross-Correlations of m-Sequences (2004)

We study the number of solutions to certain equations over finite fields and show how this gives a family of four-valued cross-correlation functions of binary m-sequences. This new family includes both of the four-valued cross-correlations found by Niho.
Vertical flaps of arbitrary shape for reflective MEMS displays and optical modulators (2011)

A novel technological platform is presented for the fabrication of vertical flaps and gratings of arbitrary shape. The flaps are suspended by torsion beams and actuated electrostatically at voltages as low as 10V. The main application is a high contrast reflective display.
Separation of Methane and Nitrogen by Adsorption on Carbon Molecular Sieve (2005)

Abstract Adsorption equilibrium of methane and nitrogen on CMS 3K from Takeda Corp. were gravimetrically measured at 298, 308, and 323 K and at pressures up to 2000 kPa. The most adsorbed gas is methane followed by nitrogen. The adsorption loading at 550 kPa and 308 K is 1.73 mol/kg for methane and 0.91 mol/kg for nitrogen. Experimental data were fitted with the multisite Langmuir model. Single component uptake of these gases at low pressures was used to determine the adsorption kinetics. Adsorption of nitrogen is much faster than methane, although this gas is preferentially adsorbed. The adsorption rate of both gases was controlled by a surface barrier resistance at the mouth of the micropore combined with micropore diffusion. Breakthrough curves of pure gases and their binary mixtures were measured at ambient temperature. A bi‐LDF (Linear Driving Force) model was used to predict the fixed‐bed behavior. Large differences in the adsorption kinetics were observed: at 308 K the LDF constant ratio was Kμ,N2 /Kμ,CH4 =133, although because of much higher adsorption of methane, the overall kinetic selectivity was 1.9 at 308 K. The data obtained in this work can be used for adsorption separation processes modeling for methane purification from nitrogen‐contaminated streams.
Continuum of All-Pair Shortest-Path to All-Path via Random Walk (2013)

A method is proposed to compute the continuum of paths, from shortest paths to all random paths between all pairs of nodes at once in a unified way. The analysis is based on treating the network as a random walk with an additional absorbing state named evaporating state reachable with nonzero probability from any state (so called "evaporating random walk"). The probability of avoiding absorption is tuned by a single parameter varying between 0 and 1, with lower values favoring shorter paths. A computational example is used to illustrate the method.
Incidence of zebra mussel on U.S. Army Corps of Engineers structures (2020)

Zebra mussels (Dreissena polymorpha) are invasive/nuisance species first introduced into the Great Lakes region in the late 1980s. Since their introduction efforts have been underway to prevent and/or control their spread. Zebra mussel infestations can occur on submerged critical structure. For the U.S. Army Corps of Engineers (USACE) it is essential that hydraulic infrastructure are effectively and efficiently maintained to ensure proper water control and navigation. A study was conducted to determine the extent of the zebra mussel invasion on USACE districts and the impact zebra mussels have on USACE infrastructure. Consistent with available U.S. Geological Survey (USGS) data, it was found that zebra mussels are present within 24 of the 36 continental United States USACE district boundaries, although San Francisco and Galveston Districts have only isolated populations in non-USACE waters. Albuquerque and Omaha Districts appear to be the two districts most at risk for invasion. While infestations are common, 62% of the districts with USACE infested waters reported no or minimal impacts on the infrastructure or operation/maintenance costs. Those districts with impacts did not normally have cost figures readily available. It was also found that 12 districts have or have had zebra mussel monitoring programs in place.
ChemInform Abstract: Oxygen Evolution on Nickel Oxide Electrodes. (1986)

Abstract The O 2 evolution reaction on Teflon‐bonded NiO and Li‐doped NiO in KOH is studied as a function of OH′ concentration.
PGSE diffusion, 1H–19F HOESY and NMR studies on several [Rh(1,5‐COD)(Biphemp)]X complexes: detecting positional anion effects (2004)

Three new salts of Rh(I), [Rh(1,5-COD)(Biphemp)]X, Biphemp = (6,6'-dimethylbiphenyl-2,2'-diyl)bis(diphenylphosphine), X = BF4-, 2a, PF6-, 2b, and CF3SO3-, 2c, were prepared and studied using PGSE diffusion, 1H-19F HOESY and inverse 103Rh (amongst other) NMR methods. Although the immediate coordination sphere of the cation does not sense the change in the anion, the PGSE diffusion and 1H-19F HOESY data suggest that, in addition to some ion pairing, each of the anions in 2 demonstrates selectivity in its approach towards the cation.
Controlled Electrostatic Gating of Carbon Nanotube FET Devices (2006)

Carbon nanotube transistors are a promising platform for the next generation of nonoptical biosensors. However, the exact nature of the biomolecule interactions with nanotubes in these devices remains unknown, creating one of the major obstacles to their practical use. We assembled alternating layers of oppositely charged polyelectrolytes on the carbon nanotube transistors to mimic gating of these devices by charged molecules. The devices showed reproducible oscillations of the transistor threshold voltage depending on the polarity of the outer polymer layer in the multilayer film. This behavior shows excellent agreement with the predictions of a simple electrostatic model. Finally, we demonstrate that complex interactions of adsorbed species with the device substrate and the surrounding electrolyte can produce significant and sometimes unexpected effects on the device characteristics.
Reducing risk in seismic acquisition and interpretation of complex targets using a Gocad‐based 3D modeling tool (1998)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1998Reducing risk in seismic acquisition and interpretation of complex targets using a Gocad‐based 3D modeling toolAuthors: Graham CainGuillaume CamboisMaurice GéhinRod HallGraham CainCGG Houston, Guillaume CamboisCGG Houston, Maurice GéhinCGG Houston, and Rod HallCGG Houstonhttps://doi.org/10.1190/1.1820363 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1820363FiguresReferencesRelatedDetailsCited ByGeological modelling and finite difference forward realization of a regional section from the Zagros fold-and-thrust belt1 August 2007 | Petroleum Geoscience, Vol. 13, No. 3Model‐based 3‐D seismic survey design as an optimization problemGabriel Alvarez, Victor Pereyra, and Laura Carcione3 January 2005 SEG Technical Program Expanded Abstracts 1998ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1998 Pages: 2092 publication data© 1998 Copyright © 1998 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 06 Jan 2005 CITATION INFORMATION Graham Cain, Guillaume Cambois, Maurice Géhin, and Rod Hall, (1998), "Reducing risk in seismic acquisition and interpretation of complex targets using a Gocad‐based 3D modeling tool," SEG Technical Program Expanded Abstracts : 2072-2075. https://doi.org/10.1190/1.1820363 Plain-Language Summary PDF DownloadLoading ...
Automatic feature extraction to support Mountains Mapping in OSM (2019)

Nahime Torres et al. (2019). Automatic feature extraction to support Mountains Mapping in OSM In: Minghini, M., Grinberger, A.Y., Juhász, L., Yeboah, G., Mooney, P. (Eds.). Proceedings of the Academic Track at the State of the Map 2019, 31-32. Heidelberg, Germany, September 21-23, 2019. Available at https://zenodo.org/communities/sotm-2019 DOI: 10.5281/zenodo.3387719
Demonstration of spatially programmable chemical vapor deposition: Model-based uniformity∕nonuniformity control (2006)

A new chemical vapor deposition (CVD) reactor design was developed to intentionally induce spatially nonuniform film thickness deposition patterns on a single wafer. A segmented showerhead design allows individual regions of a wafer to be exposed to different precursor concentrations simultaneously during a run resulting in different thickness profiles on the wafer and a thickness gradient at the boundaries between segment regions. Different recipes were cycled through each of the segments in a sequence of deposition experiments to develop a model relating precursor concentration to film thickness in each segment region. As a demonstration of spatial programmability, the system was reprogramed using this model to produce uniform thickness amongst the segments; intersegment uniformity approaching 0.60% (thickness standard deviation) was demonstrated. Potential applications of this reactor design to combinatorial CVD are discussed.
An Overview of Cytochrome P450 Immobilization Strategies for Drug Metabolism Studies, Biosensing, and Biocatalytic Applications: Challenges and Opportunities (2021)

Cytochrome P450s (P450s or CYPs) are a large superfamily of ubiquitous heme proteins. Consistent with their natural roles in oxidative metabolism of a broad range of substrates including antibiotics and xenobiotics and in the biosynthesis of complex natural products, there are two main biotechnological applications: drug metabolism studies and biocatalytic transformations. Metabolic analyses are typically performed with the P450 enzyme immobilized on a biosensing platform. Biocatalytic reactions also increasingly make use of immobilization methods with the goal of improving operational stability of the P450s. In this Review, we briefly introduce the growing field of enzyme immobilization then focus on the advances, benefits, and challenges that apply specifically to P450s. Classical immobilization methods are presented, and recently developed materials and strategies that address the need for operational stability, the multicomponent structure of P450s, their requirement for a source of electrons, and the need to overcome limited O2 availability are discussed in the context of metabolic, biosensing, and biocatalytic applications.
Solution structure of the Ras‐binding domain of RGL (1998)

The RGL protein, a homolog of the Ral GDP dissociation stimulator (RalGDS), has been identified as a downstream effector of Ras. In the present study, the solution structure of the Ras-binding domain of RGL (RGL-RBD) was determined by NMR spectroscopy. The overall fold of RGL-RBD consists of a five-stranded beta-sheet and two alpha-helices, which is the same topology as that of RalGDS-RBD. The backbone chemical shift perturbation of RGL-RBD upon interaction with the GTP analog-bound Ras was also examined. The solution structure of RGL-RBD, especially around some of the Ras-interacting residues, is appreciably different from that of RalGDS-RBD.
The design of the international settlement and trade finance system (2014)

In recent years, commercial Banks to accelerate the process of the international settlement business electronically, completed the unification of international settlement business processing platform, through the whole range of promote the use of the international business electronic process a leap. On the premise of international settlement business electronic, in view of the development trend in the field of international settlement and trade as well as the bank for international settlement and trade finance business bottlenecks faced by the Banks urgently need to be upgraded to international trade financing through the system from the extensive development of no rating credit constraint into the unified comprehensive credit risk control management. This article represented by bank for international settlements trade financing system, gives the bank of international settlement and trade finance system design and implementation.
Review: NF-kB activation in canine cancer (2022)

Spontaneous tumors in dogs share several environmental, epidemiologic, biologic, clinical and molecular features with a wide variety of human cancers, making this companion animal an attractive model. Nuclear factor kappa B (NF-kB) transcription factor overactivation is common in several human cancers, and there is evidence that similar signaling aberrations also occur in canine cancers including lymphoma, leukemia, hemangiosarcoma, mammary cancer, melanoma, glioma, and prostate cancer. This review provides an overview of NF-kB signaling biology, both in health and in cancer development. It also summarizes available evidence of aberrant NF-kB signaling in canine cancer, and reviews antineoplastic compounds that have been shown to inhibit NF-kB activity used in various types of canine cancers. Available data suggest that dogs may be an excellent model for human cancers that have overactivation of NF-kB.
Ethnic differences in catechol O-methyltransferase pharmacogenetics (1998)

Catechol O-methyltransferase (COMT) inactivates neurotransmitters, hormones and drugs such as levodopa. COMT activity is inherited in an autosomal recessive manner and individuals with low activity have thermolabile COMT protein. A low activity allele has been demonstrated at codon 108/158 of the soluble and membrane bound COMT protein, respectively, whereby a G to A transition results in a valine to methionine substitution, rendering the protein more thermolabile. As ethnic differences in erythrocyte COMT activity have been previously demonstrated, the frequency of low activity alleles were investigated in 265 British Caucasian, 99 British South-west Asian and 102 Kenyan individuals. Genotyping of COMT codon 108/158 was performed using a minisequencing method. Erythrocyte COMT activity was measured in 60 British Caucasian individuals by radiochemical assay. The frequency of low activity alleles was 0.54 in Caucasians, 0.49 in South-west Asians, and 0.32 in Kenyans. There was a much lower frequency of individuals with homozygous low activity allele in the Kenyan population (9%) than in Caucasians (31%) or Southwest Asians (27%). Erythrocyte COMT activity was lower and less thermostable in individuals with homozygous low activity alleles. The data provide molecular evidence that low COMT is less common in African individuals than the Caucasian population.
CAD tool autogeneration of VHDL FFT for FPGA/ASIC implementation (2012)

Hand-coding Fast Fourier Transforms (FFTs) in Hardware Description Language (HDL) is time consuming and prone to errors. Proprietary IP cores are available, however they are closed-source and unviewable. The open-source FFT generator SPIRAL is available, however it only produces parallel arithmetic solutions and thus limits the maximum FFT size that will fit in available Field Programmable Gate Arrays (FPGAs). An autogenerator of VHDL FFTs is described that takes a set of FFT parameters and generates an FFT component with feedback of occupied slices, maximum frequency, and dynamic range performance. Both parallel arithmetic and serial-parallel butterfly architectures can be generated where serial-parallel allows larger sized FFTs to fit inside available FPGA parts. Emphasis is placed on large sized serial-parallel FFTs and portability to Application-Specific Integrated Circuits (ASICs) using Cadence Encounter. Serial-parallel FFT pipeline control and FPGA hardware reduction are also investigated.