gebhart/patrepeval huggingface dataset:
Modification of the fatty acid composition of murine thioglycollate-elicited peritoneal macrophages (1989)

Conference Article| February 01 1989 Modification of the fatty acid composition of murine thioglycollate-elicited peritoneal macrophages PHILIP C. CALDER; PHILIP C. CALDER *Department of Biochemistry, University of Oxford, South Parks Road, Oxford, U.K. Search for other works by this author on: This Site PubMed Google Scholar DAVID J. HARVE; DAVID J. HARVE †University Department of Pharmacology, South Parks Road, Oxford, U.K. Search for other works by this author on: This Site PubMed Google Scholar SIAMON GORDON; SIAMON GORDON ‡Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, U.K. Search for other works by this author on: This Site PubMed Google Scholar ERIC A. NEWSHOLME ERIC A. NEWSHOLME *Department of Biochemistry, University of Oxford, South Parks Road, Oxford, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1989) 17 (1): 157–158. https://doi.org/10.1042/bst0170157 Article history Received: June 21 1988 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation PHILIP C. CALDER, DAVID J. HARVE, SIAMON GORDON, ERIC A. NEWSHOLME; Modification of the fatty acid composition of murine thioglycollate-elicited peritoneal macrophages. Biochem Soc Trans 1 February 1989; 17 (1): 157–158. doi: https://doi.org/10.1042/bst0170157 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: BSA, bovine serum albumin, VLDL, very-low-density lipoprotein This content is only available as a PDF. © 1989 Biochemical Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Flexible Learning-Free Segmentation and Reconstruction of Neural Volumes (2018)

Imaging is a dominant strategy for data collection in neuroscience, yielding stacks of images that often scale to gigabytes of data for a single experiment. Machine learning algorithms from computer vision can serve as a pair of virtual eyes that tirelessly processes these images, automatically detecting and identifying microstructures. Unlike learning methods, our Flexible Learning-free Reconstruction of Imaged Neural volumes (FLoRIN) pipeline exploits structure-specific contextual clues and requires no training. This approach generalizes across different modalities, including serially-sectioned scanning electron microscopy (sSEM) of genetically labeled and contrast enhanced processes, spectral confocal reflectance (SCoRe) microscopy, and high-energy synchrotron X-ray microtomography (μCT) of large tissue volumes. We deploy the FLoRIN pipeline on newly published and novel mouse datasets, demonstrating the high biological fidelity of the pipeline's reconstructions. FLoRIN reconstructions are of sufficient quality for preliminary biological study, for example examining the distribution and morphology of cells or extracting single axons from functional data. Compared to existing supervised learning methods, FLoRIN is one to two orders of magnitude faster and produces high-quality reconstructions that are tolerant to noise and artifacts, as is shown qualitatively and quantitatively.
Controlled Release of Antibiotics from Biodegradable Microcapsules for Wound Infection Control. (1982)

Abstract : It is the goal of this study to develop microcapsules that slowly release effective therapeutic doses of antibiotics in a wound over a 14-day period, by which time microcapsules will have been biodegraded. It is the purpose of this paper to report the in vivo results obtained using recently formulated prototype microcapsules. All initial efforts in the development of the controlled antibiotic release system have used ampicillin with lactide/glycolide copolymer as the drug vehicle. This copolymer is ideally suited for in vivo drug release since it elicits a minimal inflammatory response, is biologically compatible, and degrades under physiologic conditions. The degradation products are nontoxic and readily metabolized. All microcapsules currently formulated exist as free-flowing microspheres (250 microns in diameter) consisting of ampicillin anhydrate coated with a poly (DL-lactide-co-glycolide) excipient having a lactide:glycolide ratio of 68:32. Microcapsules of this size can be adminstered directly to a wound by a shaker-type dispenser or aerosol spray. The rate of biodegradation is controllable because it is related to the molar ratios of the constituent polymers and to the surface area of the microcapsules.
P3032 Association of skeletal muscle transcripts with fatty acid content in Nellore cattle (2016)

Fatty acids have been implicated in a variety of different biological processes — for example, activation of transcription factor. In this study, we utilized Longissimus muscle (skeletal muscle) with extreme fatty acid (FA) content to evaluate the association of different fatty acids and gene expression. The transcriptome and fatty acid profile of skeletal muscle from 200 Nellore steers was obtained by RNA-seq using Illumina platform (HiSeq 2500) and gas chromatography, respectively. Thirty animals with high (H) and 30 with low (L) skeletal muscle FA content were selected for this study for each fatty acid evaluated. The FAs used herein were oleic acid (OA), palmitic acid (PA), stearic acid (SA), linoleic acid (LA), conjugated linoleic acid cis9-tran11 (CLA-c9t11), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which were chosen based on their importance in many biological processes. These animals did not differ in their intramuscular fat content (IMF) or backfat thickness. Tophat2, HTSeq and DESeq2 programs and R packages were utilized to performed differential expression analysis between H and L groups. No differentially expressed genes (DEGs, FDR 10%) were identified for LA or SA; only a few DEGs were identified for EPA (5), DHA (4 DEGs) and PA (123 DEGs); while a large number of DEGs were identified for OA (1134) and CLA-c9t11 (872). Functional annotation and enrichment from OA DEGs identified important genes and canonical pathways such as SCD, PLIN5, LDL-cholesterol, CPT1 and PPAR, related to oxidative phosphorylation, insulin receptor signaling, docosahexaenoic acid (DHA) signaling and oleate biosynthesis. Enrichment analysis of CLA-c9t11 DEGs identified one KEGG pathway, Ribosome (BH-adj = 1.2e-02), and several molecular functions such as nucleotide binding (BH-adj = 1.7e-03), ATP binding (BH-adj = 2.2e-02) and structural constituent of ribosome (BH-adj = 2.4e-02). In this study, animals of common nutrition, sex and similar age with no statistical difference in IMF and backfat thickness had many DEGs due to variation in OA and CLA-c9t11 content. These results indicate that only a couple of fatty acids appear to have potential biological activity, by either direct or indirect effects, on skeletal muscle and possibly other tissues in Nellore beef cattle.
Load compensating reactions to perturbations at wrist joint in normal man (1981)

The electromyographic responses to step torque loads were studied in flexors and extensors at the human wrist. Based on temporal bursting patterns and functional behavior, the response was divided into four temporal components. Two early components, the myotatic (30-60 ms) late myotatic (60-120 ms) appears to be reflex response. The third postmyotatic component (120-200 ms) appear to be a triggered reaction, preceeding the fourth, stabilizing component (200-400 ms). A comparison of response at the wrist with similar data at the ankle provides the basis for a generalized classification of the response in various muscles to torque step perturbations.
Gravity – for better or verse (1990)

No one has ever accused John Archibald Wheeler of moderation; and, with the publication of this book, it is a certainty that no one ever will. A Journey into Gravity and Spacetime is a brilliant, personal, outrageous, quirky, inspired, annoying, gorgeous, and in the end almost unreadable popular account of Einstein's general theory of relativity, and the conceptual framework surrounding that 'battle tested' theory. Unreadable though it may be, this is probably one of the two best popular books ever written on the subject, the other being (in my judgement) Robert Geroch's modest and closely reasoned, 1978 General Relativity from A to B.
Abstract 8935: Differentiation of Left Atrial Volume by Time Measured by Speckle Tracking Echocardiography as a Novel Index of Left Atrial Global and Phasic Function (2011)

Background: Left atrial (LA) strain rate (SR) is proposed to assess LA relaxation, conduit function and contraction. Differentiation of strain by time (SR) is one dimensional parameter, but differentiation of LA volume by time (dV/dt) is three dimensional parameter. Thus, we hypothesized that LA dV/dt is more useful index of LA global and phasic function. Methods: We examined 138 subjects; normal (n=54, age 69±11 yrs, 30 men), hypertensive pts (HTN) with normal systolic function (n=84, age 71±9 yrs, 48 men). LA peak dV/dt and SR at systole, early diastole and atrial contraction were measured by speckle tracking which can automatically provide dV/dt from time-LA volume curve (Figure). LA peak dV/dt and SR in HTN were compared to normal. Time from onset of R wave on ECG to peak dV/dt at each phase was compared to that to peak SR. Results: Inter and intraobserver correlation coefficient for dV/dt at each phase was 0.97-0.99. There was a good relation between dV/dt and SR (r=0.94, p&lt;0.01). Time to peak dV/dt was comparable to time to peak SR at each phase (208±62 vs. 189±56, 523±50 vs. 527±51, 921±161 vs. 920±162msec, respectively, p&lt;0.01). Peak positive dV/dt and SR at systole in HTN were reduced compared to normal (178±35 vs. 204±47 ml/s, 1.1±0.3 vs. 1.3±0.4 s- 1 , respectively, p&lt;0.05). Peak negative dV/dt and SR at early diastole in HTN were lower (-174±62 vs. -216±92ml/s, -0.9±0.3 vs. -1.4±0.6 s- 1 , respectively, p&lt;0.05), associated with elevated E/e’ (9.0±1.9 vs. 7.2±1.9, p&lt;0.01). Despite no difference in peak SR at atrial contraction between 2 groups, peak negative dV/dt in HTN was higher than normal (-222±67 vs. -147±74 ml/s, p&lt;0.01). Conclusions: LA relaxation assessed by dV/dt and SR was reduced in HTN and conduit function was also reduced in HTN by impaired diastolic function. LA active contraction assessed by dV/dt was increased in HTN to compensate reduced conduit function. Measurement of LA dV/dt may be more promising method to assess LA function with highly acceptable variability.
Making middleboxes someone else's problem (2012)

Modern enterprises almost ubiquitously deploy middlebox processing services to improve security and performance in their networks. Despite this, we find that today's middlebox infrastructure is expensive, complex to manage, and creates new failure modes for the networks that use them. Given the promise of cloud computing to decrease costs, ease management, and provide elasticity and fault-tolerance, we argue that middlebox processing can benefit from outsourcing the cloud. Arriving at a feasible implementation, however, is challenging due to the need to achieve functional equivalence with traditional middlebox deployments without sacrificing performance or increasing network complexity.
Channel tracking for D-BLAST for airborne platforms (2011)

Coherent symbol detection requires knowledge of channel state information. The traditional use of embedding pilot symbols with payload data may not be easy to justify if channel variation is fast and/or the data rate requirement is high. We consider the implementation of the D-BLAST algorithm for airborne platforms and develop channel tracking schemes that eliminate or reduce the use of pilot symbols. In a normal operation mode, channel update is achieved dynamically as each layer of the D-Blast, encoded using an LDPC code, is decoded. We find the optimal symbol length to estimate a SISO channel under the Rayleigh channel model and then generalize it to the MIMO case. To ensure that the transceiver can detect outage due to the loss of channel state, an adaptive algorithm is devised utilizing the extremal property of the terminating likelihood ratio of an LDPC decoder.
Viral Infections and Lower Urinary Tract Symptoms in the Third National Health and Nutrition Examination Survey (2007)

In this cross-sectional survey of American men suggestive positive associations were observed between several viral infections and lower urinary tract symptoms, primarily in 30 to 59-year-old men. These findings provide interesting hypotheses and preliminary evidence for future etiological studies of infections and lower urinary tract symptoms.
Human Papillomavirus Vaccine Effectiveness Against HPV Infection: Evaluation of One, Two, and Three Doses (2019)

Among women who received their first dose at age ≤18, estimated HPV vaccine effectiveness was high regardless of number of doses.
Poly(vinyl alcohol)-based membranes for metoprolol transdermal delivery (2020)

In this work controlled release devices for transdermal administration of metoprolol were developed. Poly(vinyl alcohol) and poly(vinyl pyrrolidone) were used for producing membranes by solvent-casting technique. The release kinetic of the drug from the membranes was evaluated by ex-vivo experimental studies. All the prepared membranes exhibited a linear release profile in the investigated time. The enhancer Tween 80 was added into the polymeric matrices for improving their performance. Different mathematical models were used for fitting the experimental release data. The model that well described the release mechanism was the zero order, indicating a constant drug release in the time.
Cationic Polymerization of Isobutylene Using AlCl3OBu2 as a Coinitiator: Synthesis of Highly Reactive Polyisobutylene (2010)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTCationic Polymerization of Isobutylene Using AlCl3OBu2 as a Coinitiator: Synthesis of Highly Reactive PolyisobutyleneIrina V. Vasilenko, Alexander N. Frolov, and Sergei V. Kostjuk*View Author Information Research Institute for Physical Chemical Problems of the Belarusian State University, 14 Leningradskaya st., 220030 Minsk, Belarus*To whom correspondence should be sent. E-mail: [email protected] or [email protected]Cite this: Macromolecules 2010, 43, 13, 5503–5507Publication Date (Web):June 9, 2010Publication History Received27 April 2010Revised25 May 2010Published online9 June 2010Published inissue 13 July 2010https://pubs.acs.org/doi/10.1021/ma1009275https://doi.org/10.1021/ma1009275rapid-communicationACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views1817Altmetric-Citations84LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Cationic polymerization,Lewis acids,Polymerization,Polymers,Pyridines Get e-Alerts
Sistema modelo experimental para evaluar la influencia del estrés osmótico en rúcula, a través de propiedades superficiales de protoplastos (2018)

El agua disponible a nivel celular así como la temperatura, afectan significativamente el crecimiento y desarrollo de las hortalizas ytambién influyen posteriormente en la etapa postcosecha, afectando su calidad y vida útil. En este sentido, el principal problemade la rúcula (Eruca sativa) es su rápido deterioro luego de su recolección, ocasionado principalmente por la pérdida de agua,provocando su marchitamiento. En este trabajo se evaluó, mediante un sistema modelo experimental, la influencia del estrésosmótico, en las propiedades superficiales de protoplastos aislados de nervaduras de hojas de rúcula. Se observó, en la superficie delos protoplastos aislados la formación de regiones hidrofóbicas cuando el volumen celular se incrementa, según se detectó medianteel empleo de la sonda Merocianina 540 (MC540). El análisis del equilibrio de las especies del colorante indica que la distribución demonómeros y dímeros de MC540 varía en cada estadío osmótico. Se sugiere que lo observado es una consecuencia de los cambiosproducidos en el empaquetamiento superficial a nivel de la membrana, debido a la afinidad de este colorante con los ambienteslipídicos, que podrían ser importantes para la interacción de enzimas y otros solutos producidos por las plantas durante el estréshídrico. Este análisis puede ser de importancia para predecir los cambios en el estado del cultivo bajo ciertas condiciones, causadaspor estreses bióticos y abióticos, y también para obtener información sobre los cambios que ocurren en la morfología a nivel celular,producidos en los diversos estadios de conservación de la rúcula. Por medio de la metodología aplicada sería posible comprendermejor los procesos involucrados, relacionándolos con los cambios macroscópicos, ampliando así las herramientas tecnológicas parael control de los procesos que afectan la calidad poscosecha de hortalizas
Safety and Efficacy of a Novel Curculigo orchioides Extract in Boosting Testosterone Levels in Male Rats (2018)

Curculigo orchioides Gaertn (family Hypoxidaceae, also known as black or kali musli), is an endangered medicinal plant used for diverse medicinal purposes including impotency, aphrodisiac, diuretic, tonic, jaundice, and skin ailments. Phytochemical investigations of rhizomes revealed the presence of a novel phenolic glycoside, curculigoside, triterpenoid, saponins, flavones, cellulose, hemicellulose, and calcium oxalate. We developed a novel extract of Curculigo orchioides (Blamus™, standardized to 30% curculigosides) and assessed its dose‐and time‐dependent efficacy (0, 10, 25 and 50 mg/kg body weight p.o.) on body weight, serum free and total testosterone levels in male rats (200–230 grams; n = 6) over a period of 28 days. Blamus™ didn't cause any marked elevation in serum free testosterone levels at either10 or 25 mg/kg body weight doses, however, a 50 mg/kg body weight dose of Blamus™ induced a significant increase in serum free testosterone level (*p &lt; 0.0001). However, no significant increases were observed in serum total testosterone levels at 0, 10, 25 or 50 mg/kg body weight doses of Blamus™. Extensive testicular histopathological analyses including investigations on the seminiferous tubules, spermatogenesis, sperm cell morphology, Leydig cells and Sertoli cells following treatment with either 0, 10, 25 or 50 mg/kg body weight doses of Blamus™ demonstrated dose‐dependent improvement in structural integrity. Furthermore, no significant changes were observed in serum SGOT, SGPT, BUN and creatinine levels following treatment with any of the given doses, which demonstrated its safety profiles. These data demonstrated that Blamus™ may serve as a safe and novel, natural testosterone booster and provide broad spectrum application is sports nutrition, muscle building and exercise pathophysiology. Support or Funding Information This Project was Funded by Cepham Inc., Piscataway, NJ This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Tangent bundles of homogeneous spaces are homogeneous spaces (1972)

In this paper we describe how the tangent bundle of a homogeneous space can be viewed as a homogeneous space.
Modular Protein Supplements and Their Application to Long‐Term Care (2006)

Modular protein supplements are added to either the diet or enteral formula to increase the protein or amino acid intakes of people who are nutritionally compromised. Protein supplements are aggressively marketed to long-term care clinicians because protein energy malnutrition and wounds are a common problem in this care setting. It can be challenging for clinicians to distinguish one product from another and to determine the best product for a specific application or nutrition care goal. Modular protein products can be sorted into 4 categories: (1) protein concentrates derived from a complete protein such as milk, soy, or eggs; (2) protein concentrates derived from collagen, either alone or in combination with a complete protein; (3) doses of 1 or more dispensable (nonessential) amino acids; and (4) hybrids of the complete or collagen-based proteins and amino acid dose. Modular protein supplements are generally provided either as a substrate for protein synthesis or as a source of 1 or more amino acids that may be conditionally indispensable (conditionally essential) under certain disease conditions. This review provides guidelines for the use of modular protein supplements according to their intended physiologic function and the assessment and nutrition care goals of the long-term care resident.