gebhart/patrepeval huggingface dataset:
Fine Mapping of Polymorphic Alcohol‐Related Quantitative Trait Loci Candidate Genes Using Interval‐Specific Congenic Recombinant Mice (2002)

These three central nervous system genes (Znf142, Ptprn, and Znf133) represent promising candidates for involvement in the differential sensitivity to alcohol exhibited between ILS and ISS mice. This study also demonstrates how the combination of high-throughput comparative gene sequencing and concomitant genetic fine mapping of QTL regions with ISCRs can be an effective tool for accelerating the process of moving from QTL to gene.
Modelling and Analysis of Communication Traffic Heterogeneity in Opportunistic Networks (2015)

In opportunistic networks, direct communication between mobile devices is used to extend the set of services accessible through cellular or WiFi networks. Mobility patterns and their impact in such networks have been extensively studied. In contrast, this has not been the case with communication traffic patterns, where homogeneous traffic between all nodes is usually assumed. This assumption is generally not true, as node mobility and social characteristics can significantly affect the end-to-end traffic demand between them. To this end, in this paper, we explore the joint effect of traffic patterns and node mobility on the performance of popular forwarding mechanisms, both analytically and through simulations. Among the different insights stemming from our analysis, we identify conditions under which heterogeneity renders the added value of using extra relays more/less useful. Furthermore, we confirm the intuition that an increasing amount of heterogeneity closes the performance gap between different forwarding policies, making end-to-end routing more challenging in some cases, or less necessary in others. To our best knowledge, this is the first effort to model, analyze, and quantify effects of traffic heterogeneity. We believe this is an important step towards better protocol design and evaluation of the feasibility of applications in opportunistic networks.
Trichoderma harzianummight impact phosphorus transport by arbuscular mycorrhizal fungi (2011)

Trichoderma sp. is a biocontrol agent active against plant pathogens via mechanisms such as mycoparasitism. Recently, it was demonstrated that Trichoderma harzianum was able to parasitize the mycelium of an arbuscular mycorrhizal (AM) fungus, thus affecting its viability. Here, we question whether this mycoparasitism may reduce the capacity of Glomus sp. to transport phosphorus ((33)P) to its host plant in an in vitro culture system. (33)P was measured in the plant and in the fungal mycelium in the presence/absence of T. harzianum. The viability and metabolic activity of the extraradical mycelium was measured via succinate dehydrogenase and alkaline phosphatase staining. Our study demonstrated an increased uptake of (33)P by the AM fungus in the presence of T. harzianum, possibly related to a stress reaction caused by mycoparasitism. In addition, the disruption of AM extraradical hyphae in the presence of T. harzianum affected the (33)P translocation within the AM fungal mycelium and consequently the transfer of (33)P to the host plant. The effects of T. harzianum on Glomus sp. may thus impact the growth and function of AM fungi and also indirectly plant performance by influencing the source-sink relationship between the two partners of the symbiosis.
Etude de structures innovantes pour la réalisation d'amplificateur RF faible bruit sans inductance et à très faible consommation (2013)

During the past decade the intense development of wireless technologies standard such as WIFI, GSM or Bluetooth reshaped the connectivity environment of any technology customers Among those standards, Wireless Sensor Networks (WSN) and Wireless Personal Area Network (WPAN) are expected to play a key role in our future environments. The large scale spreading of such sensors has been enabled through the strong cost optimization of modern CMOS technologies. The autonomy improvement of such sensor is however a primary concern to allow any kind of remote operation within the limitation of battery life. Even though the emerging energy harvesting domain offer energy friendly environments for such sensor, the electrical autonomy remain as a tight challenge to address. Those requirements of autonomy along with the context of CMOS technology development pushes sometimes fundamental contradictions between circuit's miniaturization and decreased power consumption. In this work, we propose solutions to address simultaneously those autonomy-miniaturization requirements. The study presented here is focused on Low Noise Amplifiers (LNA) and more precisely on the specific case of inductorless design of LNA. Several innovative solutions has been proposed and realized in 65nm & 130nm CMOS technologies in order to highlight the pros and the cons of such design approach. First part of this work is focused on the design of an active inductance to address the area occupation of narrow band system using inductors. We'll explain why such approach rises fundamental limits for radio application. Second part details the design of an ultra low power broadband LNA without inductors. The proposed circuits enable significant improvement in performance tradeoffs for such low power consumption in comparison with known design techniques. We will conclude with general perspectives and other possible design approaches.
Early Hospital Readmissions and Mortality in Patients With Decompensated Cirrhosis Enrolled in a Large National Health Insurance Administrative Database (2017)

Patients with decompensated cirrhosis have high rates of hospitalization and frequently experience an early readmission. An early readmission to an acute care hospital is an independent predictor of mortality in patients with decompensated cirrhosis for at least 1 year following initial hospitalization.
Towards a Study of Situation Types of Irish (2000)

In this paper we analyse the structure of situation types as found in Irish. We translate these situation types into a logical metalanguage, giving the logical structure of each type. We do this to differentiate, for Irish, the aktionsarten distinctions of state, activity, achievement and accomplishment as they are found within the language. The motivation of this paper is therefore to describe the aktionsart of modern Irish and to determine the logical structure that underpins these situation types.
Design of turbo codes without 4-cycles in Tanner graph representation for message passing algorithm (2011)

Turbo code and Low Density Parity Check (LDPC) code are both recommended as FEC code in many communication standards owing to their impressive error correcting performance. Aiming at the common architecture which can decode both of the two codes, this paper describes the method of decoding turbo codes with message passing algorithm which is conventionally used for LDPC codes. In this method, turbo codes are viewed as block codes and the sparse parity check matrices are constructed through Smith Decomposition or GBT (Generator matrix based transformation). In order to guarantee decoding performance, we propose the criterion of turbo codes with no 4-cycles, which is mathematically proved and demonstrated by the simulation results.
Pyrazolato Metal Complexes: Synthesis, Characterization and X-ray Crystal Structures of Polynuclear Organometallic Re–Mn Derivatives (2000)

By reacting [Re(CO)(3)(Hpz)(2)(pz)] (Hpz = pyrazole) with [Mn(CO)(5)Br] in toluene in the presence of Et3N, the dinuclear complex [(CO)(3)Re(pz)(3)Mn(CO)(3)](Et3NH) (1) was obtained. The reaction of 1 with molecular oxygen affords the tetranuclear compound [(CO)(3)Re(pz)(3)Mn(O)(3)Mn(pz)(3)Re(CO)(3)](Et3NH)(2) (3) or the trinuclear compound [(CO)(3)Re(pz)(3)Mn(pz)(3)Re(CO)(3)] (Et3NH)(2) (5) depending on the experimental conditions. Complexes 1, 3 and 5 were characterized in the solid state by single crystal X-ray diffraction analysis and were showed to contain Re ... Mn interactions Linked by and tris-mu(2)-pyrazolato bridges. In 5, a short [2.397(4) Angstrom] tris(mu(2)-oxo)bridged Mn-IV-Mn-IV contact is found, leading to strong antiferromagnetic coupling of the d(3) ions. The homometalllic species [(CO)(3)Mn(pz)(3)Mn(CO)(3)]-(Et3NH) (2) was also prepared and found to be isostructural with 1.
Tuning Hydrogels by Mixing Dynamic Cross‐Linkers: Enabling Cell‐Instructive Hydrogels and Advanced Bioinks (2021)

Rational design of hydrogels that balance processability and extracellular matrix (ECM) biomimicry remains a challenge for tissue engineering and biofabrication. Hydrogels suitable for biofabrication techniques, yet tuneable to match the mechanical (static and dynamic) properties of native tissues remain elusive. Dynamic covalent hydrogels possessing shear-thinning/self-healing (processability) and time-dependent cross-links (mechanical properties) provide a potential solution, yet can be difficult to rationally control. Here, the straightforward modular mixing of dynamic cross-links with different timescales (hydrazone and oxime) is explored using rheology, self-healing tests, extrusion printing, and culture of primary human dermal fibroblasts. Maintaining a constant polymer content and cross-linker concentration, the stiffness and stress relaxation can be tuned across two orders of magnitude. All formulations demonstrate a similar flow profile after network rupture, allowing the separation of initial mechanical properties from flow behavior during printing. Furthermore, the self-healing nature of hydrogels with high hydrazone content enables recyclability of printed structures. Last, a distinct threshold for cell spreading and morphology is observed within this hydrogel series, even in multi-material constructs. Simple cross-linker mixing enables fine control and is of general interest for bioink development, targeting viscoelastic properties of specific cellular niches, and as an accessible and flexible platform for designing dynamic networks.
Genetic Basis and Outcome in a Nationwide Study of Finnish Patients with Hypertrophic Cardiomyopathy (2019)

We identified pathogenic and likely pathogenic mutations in 38% of Finnish patients with HCM. Four major sarcomere mutations accounted for 28% of HCM cases, whereas HCM-related mutations in non-sarcomeric genes were rare. Mortality in patients with HCM exceeded that of the general population. Finally, among 5.2 million Finns, there were at least 27 HCM-related deaths annually.
Estimation on Removal of Nitrogen and Phosphorus through Fisheries of Gracilaria verrucosa at an Estuarine Lagoon, Lake Nakaumi, Japan. (1997)

大型植物の漁獲が富栄養化湖沼における栄養物質の削減対策としてどの程度の効果を期待できるのかを見積もるために,閉鎖性汽水域である中海の大型藻類の窒素・リン濃度を分析した。Gracilaria uerrucosa(オゴノリ)の窒素・リン濃度はそれぞれ3.1%drywおよび0.21%dry wであったことから,オゴノリの漁獲が盛んであった1960年当時の年間出荷量(551t dry w)には窒素とリンがそれぞれ17tおよび1.2t含まれていたと見積もられた。これは現在の宍道湖・大橋川・中海への窒素とリンの年間流入負荷量の0.56%および0.41%に相当した。1960年当時のオゴノリの漁獲量は生産量の約13%であったと推定されていたことから,年間漁獲量を5倍(年間生産量の65%)に増やせるとすると,宍道湖・大橋川・中海への窒素とリンの流入負荷に対して2.8%および2.0%を中海におけるオゴノリの漁獲だけで除去することが可能になると見積もられた。
Abstract A89: Glycolytic cancer cell metabolism suppressed by transplantation of exogenous normal mitochondria into human breast cancer cells (2016)

Abstract Most cancer cells switch metabolism from mitochondria-based glucose oxidation to cytoplasmic glycolysis even under normoxia (the Warburg effect). The effect promotes tumorigenesis, cancer growth, invasion and drug resistance. We hypothesize that introduction of normal mitochondria into cancer cells might suppress the Warburg effect. Normal human (MCF-12A) and mouse (EpH4-Ev) mammary epithelia, and human breast cancer (MCF-7) and mouse mammary adenocarcinoma (4T1) cell lines were used in this study. We found that isolated fluorescent probe-stained mitochondria of MCF-12A or EpH4-Ev could enter into cancer cells when co-cultured with MCF-7 or 4T1 cells respectively, confirmed by fluorescent and confocal microscopy. The mitochondria from MCF-12A cells inhibited the proliferation of breast cancer MCF-7 cells in a dose dependent pattern and increased drug sensitivity of MCF-7 cells to doxorubicin, paclitaxel and carboplatin. Real time qPCR showed that exogenous normal mitochondria suppressed the gene expression of 11 glycolytic enzymes, and glucose transporter 1 and 3 of MCF-7 cells. These results suggest that normal mitochondria suppress cancer proliferation and increase drug sensitivity by the mechanism of inhibition of cancer cell glycolysis and glucose consumption. Isolated mitochondria have remained viable in culture for over three weeks and still actively entered cancer cells and inhibited cancer proliferation. In mouse model bearing the 4T1 mammary adenocarcinoma, isolated MitoTracker orange dye-stained mitochondria of EpH4-Ev, when directly injected into tumor mass, entered into 4T1 cancer cells in 24 hours. Therefore, normal mitochondrial transfer could be a cell-based therapy for cancer and other mitochondrial disorders. Citation Format: Robert L. Elliott, Xian-Peng Jiang, Jonathan F. Head. Glycolytic cancer cell metabolism suppressed by transplantation of exogenous normal mitochondria into human breast cancer cells. [abstract]. In: Proceedings of the AACR Special Conference: Metabolism and Cancer; Jun 7-10, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(1_Suppl):Abstract nr A89.
Asynchronous Federated Continual Learning (2023)

The standard class-incremental continual learning setting assumes a set of tasks seen one after the other in a fixed and pre-defined order. This is not very realistic in federated learning environments where each client works independently in an asynchronous manner getting data for the different tasks in time-frames and orders totally uncorrelated with the other ones. We introduce a novel federated learning setting (AFCL) where the continual learning of multiple tasks happens at each client with different orderings and in asynchronous time slots. We tackle this novel task using prototype-based learning, a representation loss, fractal pre-training, and a modified aggregation policy. Our approach, called FedSpace, effectively tackles this task as shown by the results on the CIFAR-100 dataset using 3 different federated splits with 50, 100, and 500 clients, respectively. The code and federated splits are available at https://github.com/LTTM/FedSpace.
Subpixel measurements using a moment-based edge operator (1989)

Recent results in precision measurements using computer vision are presented. An edge operator based on two-dimensional spatial moments is given. The operator can be implemented for virtually any size of window and has been shown to locate edges in digitized images to a twentieth of a pixel. This accuracy is unaffected by additive or multiplicative changes to the data values. The precision is achieved by correcting for many of the deterministic errors caused by nonideal edge profiles using a lookup table to correct the original estimates of edge orientation and location. This table is generated using a synthesized edge which is located at various subpixel locations and various orientations. The operator is extended to accommodate nonideal edge profiles and rectangularly sampled pixels. The technique is applied to the measurement of imaged machined metal parts. Theoretical and experimental noise analyses show that the operator has relatively small bias in the presence of noise.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Master Production Rescheduling Policy in Capacity-Constrained Just-In-Time Make-To-Stock Environments (1996)

This paper describes a simulation experiment to evaluate the relative effectiveness of rescheduling policies in capacity-constrained, just-in-time (JIT) make-to-stock production environments. Three performance measures were analyzed: average finished goods inventory, total units of sales lost, and a measure of schedule instability. Among the three loading methods we studied (level loading, front loading, and back loading), none was superior across all three performance measures. Level loading was the most robust, while back loading had an interaction effect with forecasting model and capacity level. Time fence scenario was found not to be as significant a factor in system performance as reported by previous research. Once an acceptable time fence scenario is selected, attempts to optimize this factor do not appear to offer significant improvement. It was found that higher demand variation, larger forecast errors, and tight capacity lead to the degradation of system performance. Judicious use of slack capacity helps a system to incorporate the periodic schedule changes typical of JIT systems.
Invasion and replication of Yersinia ruckeri in fish cell cultures (2018)

Like many members of the Enterobacteriaceae family, Yersinia ruckeri has the ability to invade non professional phagocytic cells. Intracellular location is advantageous for the bacterium because it shields it from the immune system and can help it cross epithelial membranes and gain entry into the host. In the present manuscript, we report on our investigation regarding the mechanisms of Y. ruckeri’s invasion of host cells. A gentamycin assay was applied to two isolates, belonging to both the biotype 1 (ATCC 29473) and biotype 2 (A7959–11) and using several cell culture types: Atlantic Salmon Kidney, Salmon Head Kidney and, Chinook salmon embryos cells at both low and high passage numbers. Varying degrees of sensitivity to Y. ruckeri infection were found between the cell types and the biotype 1 strain was found to be more invasive than the non-motile biotype 2 isolate. Furthermore, the effect of six chemical compounds (Cytochalasin D, TAE 226, vinblastine, genistein, colchicine and, N-acetylcysteine), known to interfere with bacterial invasion strategies, were investigated. All of these compounds had a significant impact on the ability of the bacterium to invade host cells. Changes in the concentration of bacterial cells over time were investigated and the results suggested that neither isolate could survive intracellularly for sustained periods. These results suggest that Y. ruckeri can gain entrance into host cells through several mechanisms, and might take advantage of both the actin and microtubule cytoskeletal systems.
A Computer-Based Automated Algorithm for Assessing Acinar Cell Loss after Experimental Pancreatitis (2014)

The change in exocrine mass is an important parameter to follow in experimental models of pancreatic injury and regeneration. However, at present, the quantitative assessment of exocrine content by histology is tedious and operator-dependent, requiring manual assessment of acinar area on serial pancreatic sections. In this study, we utilized a novel computer-generated learning algorithm to construct an accurate and rapid method of quantifying acinar content. The algorithm works by learning differences in pixel characteristics from input examples provided by human experts. HE-stained pancreatic sections were obtained in mice recovering from a 2-day, hourly caerulein hyperstimulation model of experimental pancreatitis. For training data, a pathologist carefully outlined discrete regions of acinar and non-acinar tissue in 21 sections at various stages of pancreatic injury and recovery (termed the "ground truth"). After the expert defined the ground truth, the computer was able to develop a prediction rule that was then applied to a unique set of high-resolution images in order to validate the process. For baseline, non-injured pancreatic sections, the software demonstrated close agreement with the ground truth in identifying baseline acinar tissue area with only a difference of 1% ± 0.05% (p = 0.21). Within regions of injured tissue, the software reported a difference of 2.5% ± 0.04% in acinar area compared with the pathologist (p = 0.47). Surprisingly, on detailed morphological examination, the discrepancy was primarily because the software outlined acini and excluded inter-acinar and luminal white space with greater precision. The findings suggest that the software will be of great potential benefit to both clinicians and researchers in quantifying pancreatic acinar cell flux in the injured and recovering pancreas.
Role of doping concentration on the competition between amplified spontaneous emission and nonradiative energy transfer in blends of conjugated polymers (2006)

We investigated the amplified spontaneous emission (ASE) of a blend of light emitting conjugated polymers. The effects related to the acceptor/donor polymer relative concentration on both cw photoluminescence and ASE were investigated experimentally and interpreted by a quantitative model describing ASE in presence of fast non radiative energy transfer processes. The range of acceptor concentrations where ASE does not occur is experimental determined, whereas outside such interval ASE is observed from the donor or from the acceptor polymer. In particular, the blend with 10% acceptor molecules shows ASE-induced line narrowing for excitation fluences larger than $100\phantom{\rule{0.3em}{0ex}}\mathrm{\ensuremath{\mu}}\mathrm{J}\phantom{\rule{0.3em}{0ex}}{\mathrm{cm}}^{\ensuremath{-}2}$, with a maximum optical gain coefficient of $8\phantom{\rule{0.3em}{0ex}}{\mathrm{cm}}^{\ensuremath{-}1}$ and a loss coefficient as low as $0.3\phantom{\rule{0.3em}{0ex}}{\mathrm{cm}}^{\ensuremath{-}1}$. These optical and gain properties make the investigated conjugated polymer blend an appealing material as active layer for laser devices.
Edge of Chaos Is Sine Qua Non for Turing Instability (2022)

Diffusion-driven instabilities with pattern formation may occur in a network of identical, regularly-spaced, and resistively-coupled cells if and only if the uncoupled cell is poised on a locally-active and stable operating point in the Edge of Chaos domain. This manuscript presents the simplest ever-reported two-cell neural network, combining together only 7 two-terminal components, namely 2 batteries, 3 resistors, and 2 volatile NbOx memristive threshold switches from NaMLab, and subject to diffusion-driven instabilities with the concurrent emergence of Turing patterns. Very remarkably, this is the first time an homogeneous cellular medium, with no other dynamic element than 2 locally-active memristors, hence the attribute all-memristor coined to address it in this paper, is found to support complex phenomena. The destabilization of the homogeneous solution occurs in this second-order two-cell array if and only if the uncoupled cell circuit parameters are chosen from the Edge of Chaos domain. A deep circuit- and system-theoretic investigation, including linearization analysis and phase portrait investigation, provides a comprehensive picture for the local and global dynamics of the bio-inspired network, revealing how a theory-assisted approach may guide circuit design with inherently non-linear memristive devices.