gebhart/patrepeval huggingface dataset:
Gear shifting multi-objective optimization to improve vehicle performance, fuel consumption, and engine emissions (2017)

In the present work, the Adaptive-Weight Genetic Algorithm was employed in order to determine the gear shifting strategies that allow an automobile to work in the best compromise among fuel consumption, engine emissions, and vehicle performance. For the assessment of each of the three objective functions, a simulation model based on engine data and on the well-established equations of the longitudinal dynamics was developed. The driving cycle chosen for the calculations was the FTP-75, which takes into account both cold and hot starts, meaning that the transient operation during the warm-up of the catalyst is also considered.
A clinical report of Chediak–Higashi syndrome in infancy with a novel genotype from the Indian subcontinent (2015)

Chediak-Higashi syndrome (CHS; OMIM no. 214500) is an inherited multisystem disorder presenting with hypopigmentation and a propensity to infections due to immunological dysfunction. CHS generally presents in infancy with a fatal outcome, but less severe cases can present in adulthood. Treatment with bone marrow transplantation can be life-saving, so establishing a correct diagnosis is critical. The presence of large granules on examination of peripheral blood smears is suggestive of the diagnosis of CHS in most centers. However, sequencing of the lysosomal trafficking, LYST, gene confirms the diagnosis and can provide a prognosis regarding disease severity. In the case presented here, we performed molecular testing to identify the causative mutation and tabulated published mutation data from 2009 to 2014. We found a novel frameshift mutation in our case and concluded that frameshift and nonsense are the most common types of mutation in CHS, but this may be biased due to underdiagnosis of the milder and atypical forms of the disease.
Biochemical comparisons of the Saccharomyces cerevisiae Bem2 and Bem3 proteins. Delineation of a limit Cdc42 GTPase-activating protein domain. (1993)

The Bem2 and Bem3 proteins, which appear to play roles in the regulation of bud site formation in Saccharomyces cerevisiae, show striking homology to a number of proteins that compose a family of GTPase-activating proteins (GAPs) for the rho-subgroup of ras-related GTP-binding proteins. These members include human platelet GAP for Cdc42Hs (the human homolog of a S. cerevisiae GTP-binding protein that regulates bud site assembly), the break point cluster region protein, the brain protein chimerin, the 85-kDa regulatory subunit (p85) of the phosphatidylinositol 3-kinase, and the ras-GAP-binding protein (p190). A fusion protein composed of the glutathione S-transferase protein and the rho-GAP homology region of Bem3 (designated GST-Bem3) stimulates the GTPase activity of the wild-type Cdc42Hs protein (Cdc42HsGly-12), but has no stimulatory effect on a GTPase-defective mutant (Cdc42HsVal-12), whereas a GST-Bem2 fusion protein does not stimulate the GTPase activity of either form of Cdc42Hs. We have compared the ability of GST-Bem3 to serve as a GAP for Cdc42Hs relative to other members of the rho-GAP subfamily and found the following order of potency: human platelet Cdc42Hs GAP > p190 > Bem3 > break point cluster region protein, whereas p85, like Bem2, shows no GAP activity or any ability to bind to the GTP-bound form of Cdc42Hs. We have taken advantage of the functional specificity exhibited by Bem3 (versus Bem2) in using Bem2/Bem3 chimeras, as well as different deletion mutant versions of the Bem3 protein, to delineate the limits of a functional Cdc42 GAP domain. The results of this study indicate that the carboxyl-terminal approximately 224 amino acids (which contain three regions of homology to the other members of the rho-GAP family) represent a "limit GAP." The first two appear to be important for binding to Cdc42Hs and for partial GAP activity.
Accurate pose estimation from a single perspective view (2003)

The problem of guiding a mobile robot in the 3D world, using a set of known targets conveniently positioned at each of its docking stations, is discussed. A sequence of images is acquired along the way from one station to another. Each image in the sequence is processed, and motion clues are extracted to correct the 3D position and orientation of the robot caused by motion slip and inaccuracy in the mechanical assembly and platform holding the robot. Using the rigidity of the target with respect to a fixed coordinate system, the authors provide a set of equations from which a unique solution to the camera pose is determined. Tests of this solution on synthetic data are presented; they show that the analytic method is very accurate.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Topic-Independent Hybrid Approach for Sentiment Analysis of Chinese Microblog (2016)

People's attitude towards specific events is usually contained in their Internet speech. When monitoring public opinions on the Internet, the sentiments of social media users should be analyzed in real time. For example, the expression of target user should be analyzed to get his/her emotional changing trend. However, present literatures on text sentiment analysis are limited to specific domains and topics, because they usually employ machine learning method to get sentiment polarity, which is trained on one specific topic area. In this paper, our approach combines the lexicon-based with the similarity-based method to extract sentiment word, then utilize the semantic rules and emoticons to obtain the sentiment polarity of short text. The results show that the proposed approach can get higher accuracy than the SVM method on topic-independent corpus and can be applied to online sentiment analysis.
Quantitative analysis of nociceptin in blood of patients with acute and chronic pain (2002)

This study aimed to define the change of serum level of nociceptin in pain patients. Seventy pain patients and 20 normal healthy subjects were enrolled. Patients were divided into three groups according to the duration of pain; (1) acute (within 4 weeks), (2) subacute (4 weeks to 6 months), and (3) chronic (> 6 months) state. Serum concentration of nociceptin was measured by radioimmunoassay. Serum nociceptin level was significantly higher in the patients with pain than in normal healthy subjects ( rho < 0.01). Furthermore, nociceptin level was significantly higher in the chronic pain group than acute group ( rho < 0.05). Serum nociceptin level has a relationship with the existence of pain and its duration.
Effect of Myopic Undercorrection on Habitual Reading Distance in Schoolchildren: The Hong Kong Children Eye Study (2022)

A shorter reading distance was present among undercorrected myopic children. Myopia undercorrection is not recommended as a strategy for slowing myopic progression.
GAMMA KNIFE RADIOSURGERY FOR GLOMUS JUGULARE TUMORS (2006)

GKRS is a safe, effective treatment for glomus jugulare tumors, particularly in patients with preserved glossopharyngeal and vagus nerve function, after surgical recurrence, in the elderly, and in patients with serious preexisting medical conditions. Longer follow-up periods are required to assess long-term effects.
Experimental research about thermal insulation performance of various powder insulation methods (2010)

The purpose of the current study was to examine the impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 or COVID-19) on allied health professionals work environment, access to personal protective equipment (PPE) and COVID-19 testing, and mental health. A 34-question survey was developed and distributed electronically to allied health professionals through listservs of professional organizations and social media groups. A total of 921 responses from allied health professionals in a variety of work settings were analyzed. The majority of allied health professionals had access to medical-grade PPE and agreed with their clinics decisions to stay open or closed. Private practices appeared to be the most negatively impacted with regards to employment in the form of pay reductions, furloughs, lay-offs, or the requirement of using paid time off. Importantly, 86% of all respondents, irrespective of employment status, reported feeling stressed with regards to changes in their work environment and transmission of the virus. However, levels of stress were dependent upon access to PPE and mental health resources. Specifically, those with access to mental health support reported lower stress levels than those without such access. These results highlight the need for continuous monitoring of mental health for allied health professionals in order to inform clinic and hospital policies for PPE and the development of brief interventions to mitigate adverse long-term mental health outcomes.
N-glycoproteomic analysis of human follicular fluid during natural and stimulated cycles in patients undergoingin vitrofertilization (2017)

We identified and classified N-GPs in hFF to improve our understanding of follicular physiology in patients requiring assisted reproduction. Our results provided important insights into the prevention of hyperstimulation side effects, such as OHSS.
529-P: Insulin Replacement Therapy Does Not Fully Prevent Peripheral Neuropathy in Type 1 Diabetic Mice (2020)

Peripheral Neuropathy (PN) is one of the most common complications of diabetes worldwide, affecting up to 60% of diabetic patients. Despite strict glycemic control, the risk of PN persists in approximately 30% of type 1 diabetic (T1D) patients. Understanding the role of insulin in PN is therefore critical to designing adjunct therapies that can slow or reverse disease progression. In this study, we aimed to determine the effect of insulin replacement therapy on nerve function and identify metabolic and molecular changes in plasma and nerves of T1D mice that are not improved following euglycemia. Terminal metabolic and neuropathy phenotyping was performed in Streptozotocin (STZ)-induced T1D mice, treated with insulin for 12 weeks. Oxidative stress was quantified in plasma and sciatic nerve. DNA methylation and protein expression of key insulin signaling markers were also determined in dorsal root ganglia (DRG). T1D mice developed hyperglycemia, hypertriglyceridemia, reduced plasma insulin, PN, systemic and nerve oxidative stress. Additionally, DRG isolated from T1D mice exhibited hypermethylation and reduced insulin signaling. Insulin replacement therapy normalized glycemia and triglyceride levels, but induced hyperinsulinemia and markers of oxidative stress. While insulin treatment did not reverse large fiber neuropathy, it improved small fiber and sensory nerve function. This protective effect was accompanied with a restoration of methylation levels and insulin signaling markers in DRG. Our findings show that insulin treatment ameliorates small fiber function by correcting methylation and insulin signaling. However, we show that insulin treatment fails to rescue large fiber deficit, which is mediated at least in part by hyperinsulinemia and systemic oxidative stress. Accordingly, these results suggest that in addition to metabolic control, restoring oxidative balance may represent an adjunct therapy to fully prevent PN in T1D. Disclosure S. Eid: None. L.M. Hinder: None. J.M. Hayes: None. F. Mendelson: None. E.L. Feldman: Consultant; Self; Novartis Pharmaceuticals Corporation. Funding American Diabetes Association (7-12-BS-045 to E.L.F.); JDRF; Rose C. and Nathan L. Milstein Family Emerging Scholar Fund; A. Alfred Taubman Medical Research Institute
A virtual stylus method for non-destructive roughness profile measurement of additive manufactured lattice structures (2023)

Abstract Surface roughness is traditionally evaluated with contact profilometry; however, these methods are not compatible with complex additive manufactured lattice structures due to limited physical access. For these scenarios, computed tomography (CT) is often used to provide qualitative insight into surface roughness but does not directly yield roughness profile data. This research describes a hybrid approach for the non-destructive quantification of roughness profile data for lattice structures based on the mathematical reconstruction and interpretation of CT data. Formal analyses are applied to propose the theoretical minimum CT voxel size required to characterise surface roughness for a specified sampling length. The method is verified against optical data for nominally flat metallic specimens and applied to metallic and polymeric cylinders fabricated by powder bed fusion and material extrusion respectively. This research also assesses the influence of CT reconstruction thresholding as a process variable and finds that roughness profile data is only weakly influenced by thresholding settings, due to scattering effects at the surface — a novel finding that provides certainty for the industrial application of this method. The ability of the proposed method to accurately characterise the inherent surface roughness of these processes as well as the effect of specimen orientation is thus demonstrated, enabling full geometric characterisation supporting subsequent certification analysis. The method can be algorithmically implemented in combination with the generative design of complex lattice structures to support structural certification requirements.
Modeling Specular Exchange Between Concentric Cylinders in a Radiative Shielded Furnace (2000)

The objective of this research is to develop and validate mathematical models to characterize the thermal performance of a radiative shielded furnace, the University of Alabama in Huntsville (UAH) Isothermal Diffusion Oven. The mathematical models are validated against experimental data obtained from testing the breadboard oven in a terrestrial laboratory environment. It is anticipated that the validation will produce math models capable of predicting the thermal performance of the furnace over a wide range of operating conditions, including those for which no experimental data is available. Of particular interest is the furnace core temperature versus heater power parametric and the transient thermal response of the furnace. Application to a microgravity environment is not considered, although it is conjectured that the removal of any gravity dependent terms from the math models developed for the terrestrial application should yield adequate results in a microgravity environment. The UAH Isothermal Diffusion Oven is designed to provide a thermal environment that is conducive to measuring the diffusion of high temperature liquid metals. In addition to achieving the temperatures required to melt a sample placed within the furnace, reducing or eliminating convective motions within the melt is an important design consideration [1]. Both of these influences are reflected in the design of the furnace. Reducing unwanted heat losses from the furnace is achieved through the use of low conductivity materials and reflective shielding. As evidenced by the highly conductive copper core used to house the sample within the furnace, convective motions can be greatly suppressed by providing an essentially uniform thermal environment. An oven of this design could ultimately be utilized in a microgravity environment, presumably as a experiment payload. Such an application precipitates other design requirements that limit the resources available to the furnace such as power, mass, volume, and possibly even time. Through the experimental and numerical results obtained, the power requirements and thermal response time of the breadboard furnace are quantified.
Cholangitis in three critically ill patients after a severe CoVID-19 infection (2021)

Coronavirus disease 2019 (CoVID-19) is a viral disease. Although the predominant presentation is respiratory disease, other manifestations such as gastrointestinal manifestations are commonly reported. Nevertheless, it has not been associated with chronic cholangitis or hepatic injury. In this study, we report three cases of severe CoVID-19 infection that required ICU admission, intubation, and sedation with ketamine. All three patients had abnormal liver function despite recovery and were diagnosed with cholangitis in the context of CoVID-19.
Multimedia Research Platforms (1995)

Several AT&T Bell Laboratories research projects focus on multimedia information, providing new technologies for the creation, storage, transmission, retrieval, presentation, and use of such data. Other projects focus on inventing new ways to structure and use multimedia data by developing research platforms and novel applications. This paper discusses three of these platforms and associated applications: Rapport and MR, multimedia desktop conferencing and virtual meeting room service platforms; HuMaNet, a speech-controlled multitechnology conference room environment; and the Nemesis information browser, which provides desktop access to remotely stored papers, photographs, and presentations.
Active Multitask Learning Using Both Latent and Supervised Shared Topics (2014)

Multitask learning (MTL) via a shared representation has been adopted to alleviate problems with sparsity of labeled data across different learning tasks. Active learning, on the other hand, reduces the cost of labeling examples by making informative queries over an unlabeled pool of data. Therefore, a unification of both of these approaches can potentially be useful in settings where labeled information is expensive to obtain but the learning tasks or domains have some common characteristics. This paper introduces two such models – Active Doubly Supervised Latent Dirichlet Allocation (Act-DSLDA) and its non-parametric variation (Act-NPDSLDA) that integrate MTL and active learning in the same framework. These models make use of both latent and supervised shared topics to accomplish multitask learning. Experimental results on both document and image classification show that integrating MTL and active learning along with shared latent and supervised topics is superior to other methods which do not employ all of these components.
SETH1 and SETH2 , Two Components of the Glycosylphosphatidylinositol Anchor Biosynthetic Pathway, Are Required for Pollen Germination and Tube Growth in Arabidopsis [W] (2004)

Glycosylphosphatidylinositol (GPI) anchoring provides an alternative to transmembrane domains for anchoring proteins to the cell surface in eukaryotes. GPI anchors are synthesized in the endoplasmic reticulum via the sequential addition of monosaccharides, fatty acids, and phosphoethanolamines to phosphatidylinositol. Deficiencies in GPI biosynthesis lead to embryonic lethality in animals and to conditional lethality in eukaryotic microbes by blocking cell growth, cell division, or morphogenesis. We report the genetic and phenotypic analysis of insertional mutations disrupting SETH1 and SETH2, which encode Arabidopsis homologs of two conserved proteins involved in the first step of the GPI biosynthetic pathway. seth1 and seth2 mutations specifically block male transmission and pollen function. This results from reduced pollen germination and tube growth, which are associated with abnormal callose deposition. This finding suggests an essential role for GPI anchor biosynthesis in pollen tube wall deposition or metabolism. Using transcriptomic and proteomic approaches, we identified 47 genes that encode potential GPI-anchored proteins that are expressed in pollen and demonstrated that at least 11 of these proteins are associated with pollen membranes by GPI anchoring. Many of the identified candidate proteins are homologous with proteins involved in cell wall synthesis and remodeling or intercellular signaling and adhesion, and they likely play important roles in the establishment and maintenance of polarized pollen tube growth.
Functional Role of the Cytoplasmic Tail Domain of the Major Envelope Fusion Protein of Group II Baculoviruses (2006)

F proteins from baculovirus nucleopolyhedrovirus (NPV) group II members are the major budded virus (BV) viral envelope fusion proteins. They undergo furin-like proteolysis processing in order to be functional. F proteins from different baculovirus species have a long cytoplasmic tail domain (CTD), ranging from 48 (Spodoptera litura multicapsid NPV [MNPV]) to 78 (Adoxophyes honmai NPV) amino acid (aa) residues, with a nonassigned function. This CTD is much longer than the CTD of GP64-like envelope fusion proteins (7 aa), which appear to be nonessential for BV infectivity. Here we have investigated the functional role of the CTD of Helicoverpa armigera single-capsid NPV (HearNPV), a group II NPV. We combined a newly constructed HearNPV f-null bacmid knockout-repair system and an Autographa californica MNPV (AcMNPV) gp64-null bacmid knockout-pseudotype system with mutation and rescue experiments to study the functional role of the baculovirus F protein CTD. We show that except for the 16 C-terminal aa, the HearNPV F CTD is essential for virus spread from cell to cell. In addition, the CTD of HearNPV F is involved in BV production in a length-dependent manner and is essential for BV infectivity. The tyrosine residue Y658, located 16 aa from the C terminus, seems to be critical. However, HearNPV F without a CTD still rescues the infectivity of gp64-null AcMNPV BV, indicating that the CTD is not involved in processing and fusogenicity. Altogether, our results indicate that the F protein is essential for baculovirus BV infectivity and that the CTD is important for F protein incorporation into BV.
Microarray analysis of gastric mucosa among children with Helicobacter pylori infection (2012)

Lcn2, CCL18, CXCL9, CXCL11, PGI and PGII play important roles in childhood H. pylori infection.
A micro vibratory stage for on chip physical stimulation and calibration of MEMS gyroscopes (2014)

This paper presents the design and preliminary test results of a micro actuation and sensing platform to provide on chip physical stimulus for in situ calibration of long-term drifts in scale factor and offset of dual-axis MEMS gyroscopes. The platform consists of a 3-DOF micro vibratory stage that can provide piezoelectric actuation for X/Y-tilting reference stimuli, off-axis motion compensation, analog sensing of applied periodic stimulus, and electrostatic position lockdown for shock protection. Initial characterizations are performed with a commercial MEMS gyroscope (25 mg) mounted on top of the micro motion platform, while its electrical interconnects provided through microfabricated highly-flexible parylene cables. The piezoelectric stage is measured to provide up to 220 degree/sec angular AC excitation, while providing an analog sensing signal to determine the applied stimulus with a precision of 1.2 degree/sec. The estimated scale factor has < 0.8% deviation from rate-table values on the same-model gyroscope samples.