gebhart/patrepeval huggingface dataset:
Stripe Phase Hydrodynamics in Lipid Monolayers (1996)

The time-dependent serpentine distortions of the stripe phase of lipid monolayers at the air−water interface are studied by accounting for the effects of line tension and electrostatic forces within the monolayer, as well as viscous forces within both the monolayer and the subphase. It is shown that distortions that have wavelengths of the same order as the stripe widths are expected to grow or decay rapidly, depending on the relation between the stripe width and the equilibrium width. Serpentine distortions with wavelengths much larger than the stripe widths grow or decay much more slowly. Experimental data of Seul and Chen (Phys. Rev. Lett. 1993, 70, 1658−1661) on stripe phases are discussed in terms of these calculations, with the conclusion that the stripes in these phases have equilibrium widths, and that these stripe phases are stable with respect to static serpentine distortions.
The taxoids: same roots, different drugs. (1997)

The discovery and development of the taxoid class of antitumor compounds, most notably paclitaxel, originally extracted from the Pacific yew, and its semisynthetic analog docetaxel, represent significant advances in the treatment of patients with a variety of malignancies. Although paclitaxel and docetaxel have a similar chemical root, extensive research and clinical experience indicate that important biological and clinical differences exist between the two compounds. Although the mechanism by which they disrupt mitosis and cell replication is novel and unique to this class of compounds, there are small but important differences in the formation of the stable, nonfunctional microtubule bundles and in the affinity of the two compounds for binding sites. These differences may explain the lack of complete cross-resistance observed between docetaxel and paclitaxel in preclinical and clinical studies. The two taxoids also exhibit slightly different toxicity and clinical efficacy profiles. Docetaxel-induced adverse events have been shown to occur most frequently in patients with impaired liver function, and a reduction in dosage in patients with raised levels of transaminases and alkaline phosphatase is recommended to improve the tolerability of the drug in these patients. The incidence and severity of problematic adverse effects such as hypersensitivity, skin reactions, and a cumulative fluid retention syndrome are minimized with the routine administration of a 3- to 5-day corticosteroid-based premedication regimen with each docetaxel infusion. The results of ongoing studies of taxoid-based monotherapies and combination regimens will further optimize the benefits achievable with these drugs, and new preclinical findings also may lead to new clinical uses for these and future drugs of the taxoid class.
D-KEFS Tower Test performance in patients with lateral prefrontal cortex lesions: The importance of error monitoring (2008)

This study investigated performance on the Delis-Kaplan Executive Function System (D-KEFS) Tower Test in a sample of 12 patients with focal lesions in the lateral prefrontal cortex (PFC) and 12 control participants. PFC patients performed worse overall, spent more time on each move, and committed significantly more rule violations. The rule violation measure demonstrated 83% sensitivity and 100% specificity in the detection of lesions. Findings highlight the importance of error monitoring in the assessment of executive functioning. These preliminary results suggest that the lateral PFC may be critical for self-monitoring/inhibition and speed of processing in planning tasks.
60 mW 1.5 /spl mu/m single-frequency low-noise fiber laser MOPA (1994)

The operating characteristics of an efficient 60 mW, single frequency, low noise integrated master oscillator power amplifier (MOPA) with active noise suppression is presented. With active noise reduction this source demonstrated a maximum relative intensity noise of /spl minus/110 dB/Hz below the CW lasing level in the relaxation oscillation regime and a broadband RMS noise of 0.39% with respect to the CW lasing level in a 2 MHz bandwidth.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Non-coherent TOA estimation in IR-UWB systems with different signal waveforms (2005)

In this paper, signal waveform designs for TOA estimation with non-coherent receivers based on ultrawideband impulse radio are discussed. Four different transmit signal waveforms are analyzed, both with respect to their design constraints, and their precision ranging performance in IEEE 802.15.4a multipath channels. We introduce novel searchback and thresholding algorithms, and show that the ranging performance can be improved considerably with a-priori knowledge of noise variance. Simulation results show that it is possible to achieve sub-meter ranging accuracy with 90% confidence by using such energy detecting (non-coherent) receivers.
Generalized Anxiety Disorder (2015)

What are the effects of treatments for generalized anxiety disorder in adults and children and adolescents?
Synthesis of biomimetic oxygen-carrying compartmentalized microparticles using flow lithography (2013)

We report a microfluidic approach for lithographically photo-patterning compartmentalized microparticles with any 2D-extruded shape, down to the cellular length scale (~10 microns). The prepolymer solution consists of a UV crosslinkable perfluorodecalin-in-water nanoemulsion stabilized by Pluronic(®) F-68. The nanoemulsions are generated using high-pressure homogenization and are osmotically stabilized by the trapped species method. The presence of PFC droplets increases the solubility and diffusivity of oxygen in the prepolymer solution, thereby enhancing the rate of O2 inhibition during microparticle synthesis. We develop a simple model that successfully predicts the augmented O2 mass transport, which agrees well with experimental data. Informed by our analytical results, cell-sized composite microgels are generated by controlling the oxygen environment around the polydimethylsiloxane (PDMS) microfluidic synthesis device. These nanoemulsion composites are functionally similar to red blood cells as oxygen carriers. Such bio-inspired polymeric particles with controlled physical properties are promising vehicles for drug delivery and clinical diagnostics.
480: Physical Characteristics of Small Intestinal Submucosa Scaffolds are Location-Dependent (2005)

You have accessJournal of UrologyPodium, Sunday, May 22, 2005, 1:00 - 3:00pm1 Apr 2005480: Physical Characteristics of Small Intestinal Submucosa Scaffolds are Location-Dependent Bradley P. Kropp, Yuanyuan Zhang, Hsueh Kung Lin, Rick Cowan, Sundararajan V. Madihally, and Devanathan Raghavan Bradley P. KroppBradley P. Kropp More articles by this author , Yuanyuan ZhangYuanyuan Zhang More articles by this author , Hsueh Kung LinHsueh Kung Lin More articles by this author , Rick CowanRick Cowan More articles by this author , Sundararajan V. MadihallySundararajan V. Madihally More articles by this author , and Devanathan RaghavanDevanathan Raghavan More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34733-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "480: Physical Characteristics of Small Intestinal Submucosa Scaffolds are Location-Dependent." The Journal of Urology, 173(4S), p. 132 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 132 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Bradley P. Kropp More articles by this author Yuanyuan Zhang More articles by this author Hsueh Kung Lin More articles by this author Rick Cowan More articles by this author Sundararajan V. Madihally More articles by this author Devanathan Raghavan More articles by this author Expand All Advertisement PDF downloadLoading ...
Rapid characterization of combinatorial libraries using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. (1998)

The relatively new field of combinatorial chemistry has enabled researchers to create large mixtures of compounds that can be screened for leads in developing potential drug candidates. The new synthetic method has also created a need for better procedures to analyze the complex mixtures that are generated. The immediate goal in most cases is to verify the synthetic procedure and to determine the purity and completeness of the library sample before binding studies are initiated. We report here a method to rapidly characterize small-molecule combinatorial libraries in solution. All combinatorial library samples were synthesized by combining a core molecule bearing two acid chloride functionalities with various amino acids to generate libraries of 36, 78 and 120 components. Using electrospray ionization fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS) we were able to identify 70-80% of the library components. All samples were analyzed as mixtures by direct infusion without chromatographic separation. Furthermore, nominally isobaric components could be resolved and identified through exact mass assignments without tandem mass spectrometery. ESI-FTICR-MS is a rapid and convenient tool for the characterization of small-molecule libraries. The method is especially useful for the analysis of larger libraries that contain many nominally isobaric components and impurities.
Continual HyperTransformer: A Meta-Learner for Continual Few-Shot Learning (2023)

We focus on the problem of learning without forgetting from multiple tasks arriving sequentially, where each task is defined using a few-shot episode of novel or already seen classes. We approach this problem using the recently published HyperTransformer (HT), a Transformer-based hypernetwork that generates specialized task-specific CNN weights directly from the support set. In order to learn from a continual sequence of tasks, we propose to recursively re-use the generated weights as input to the HT for the next task. This way, the generated CNN weights themselves act as a representation of previously learned tasks, and the HT is trained to update these weights so that the new task can be learned without forgetting past tasks. This approach is different from most continual learning algorithms that typically rely on using replay buffers, weight regularization or task-dependent architectural changes. We demonstrate that our proposed Continual HyperTransformer method equipped with a prototypical loss is capable of learning and retaining knowledge about past tasks for a variety of scenarios, including learning from mini-batches, and task-incremental and class-incremental learning scenarios.
Targeting the TLR signalosome with TIR domain-derived cell-permeable decoy peptides: the current state and perspectives (2020)

The ability to engineer pharmaceuticals that target the signal-dependent interactions of signaling proteins should revolutionize drug development. One approach to the rational design of protein interaction inhibitors uses decoy peptides, i.e. segments of protein primary sequence, which are derived from interfaces that mediate functional protein interactions. Decoy peptides often retain the ability of the full-length prototype to bind the docking site of the folded protein and thereby block the signal transduction. This review summarizes advances made in the last decade in the development of cell-permeable decoy peptide (CPDP) inhibitors to target the Toll/IL-1R resistance (TIR) domain-mediated protein interactions in TLR signaling, in connection with the recent progress in understanding of the TLR signalosome assembly mechanisms. We present a large collection of currently available, TIR-targeting CPDPs and propose their classification based on the types of TIR–TIR interactions they target. The binding behavior of different CPDP-TIR pairs, studied in cell-based assays and in binary in vitro systems using recombinant TIR domains, is also reviewed. The available affinity data provide benchmarks for rapid preliminary evaluation of future inhibitors. We review literature that evaluates the in vivo potency of select CPDPs and attempt to outline the areas of forthcoming progress, towards the development of CPDP-based TLR inhibitors of pharmaceutical grade.
<p>Intronic Variants in OCT1 are Associated with All-Cause and Cardiovascular Mortality in Metformin Users with Type 2 Diabetes</p> (2020)

According to their OCT1 genotype, some individuals with T2DM on metformin therapy might be prone to an increased risk of cardiovascular death.
Roderick MacFarquhar: The origins of the Cultural Revolution. Vol. 2: The Great Leap Forward, 1958–1960. xvii, 470 pp. Oxford: Oxford University Press for the Royal Institute of International Affairs, the East Asian Institute of Columbia University and the Research Institute on International Change of Columbia University, 1983. £22.50. (1984)

Roderick MacFarquhar: The origins of the Cultural Revolution. Vol. 2: The Great Leap Forward, 1958–1960. xvii, 470 pp. Oxford: Oxford University Press for the Royal Institute of International Affairs, the East Asian Institute of Columbia University and the Research Institute on International Change of Columbia University, 1983. £22.50. - Volume 47 Issue 3
Molecular properties of succinate dehydrogenase isolated from Micrococcus luteus (lysodeikticus) (1983)

Succinate dehydrogenase (EC 1.3.99.1) of Micrococcus luteus was selectively precipitated from Triton X-100-solubilized membranes by using specific antiserum. The precipitated enzyme contained equimolar amounts of four polypeptides with apparent molecular weights of 72,000, 30,000, 17,000, and 15,000. The 72,000 polypeptide possessed a covalently bound flavin prosthetic group and appeared to be strongly antigenic as judged by immunoprinting experiments. Low-temperature absorption spectroscopy revealed the presence of cytochrome b556 in the antigen complex. By analogy with succinate dehydrogenase purified from other sources, the 72,000 and 30,000 polypeptides were considered to represent subunits of the succinate dehydrogenase enzyme, whereas one (or both) of the low-molecular-weight polypeptides was attributed to the apoprotein of the b-type cytochrome. A succinate dehydrogenase antigen cross-reacting with the M. luteus enzyme complex could be demonstrated in membranes of Micrococcus roseus, Micrococcus flavus, and Sarcina lutea, but not in the membranes isolated from a wide variety of other gram-positive and gram-negative bacteria.
AssociationsofPsychotherapyDoseand SSRIorSNRIRefillsWithMentalHealth OutcomesAmongVeteransWithPTSD (2014)

Objective: This study assessed associations between psychotherapy and pharmacotherapy for posttraumatic stress disorder (PTSD) and longitudinal changes in PTSD, depression, and mental health functioning among U.S. veterans diagnosed as having PTSD. Methods: Information about self-reported symptoms experienced from .5 to over three years was collected from 482 veterans diagnosed as having PTSD. Administrative data from the U.S. Department of Veterans Affairs (VA) were used to calculate initiation of a course of selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), days of medication coverage, and number of PTSD-related psychotherapy visits during the year after a baseline survey. Hierarchical linear modeling was used to analyze the effects of psychotherapy dose, initiation of an SSRI or SNRI, and medication coverage on symptoms over one year. Results: In the year after baseline, over half of the sample (55%) received no psychotherapy for PTSD, and only 8% met the VA’s proposed standard of eight PTSD-related sessions within 14 weeks. Nearly half of the participants (47%) were prescribed an SSRI or SNRI and 37% completed a 90-day trial in the year after baseline. Participants’ symptoms improved slightly over time. Participants who received eight or more psychotherapy sessions in 14 weeks, completed a 90-day course of SSRIs or SNRIs, or had more days of medication coverage did not improve more than participants who received less treatment. Conclusions: These doseof-care benchmarks were not related to symptom improvement, highlighting the importance of directly assessing the impact of particular treatments on patient outcomes rather than solely relying on process measures. (Psychiatric Services 65:1244–1248, 2014; doi: 10.1176/appi. ps.201300234)
Simulation of TaO<inf>x</inf>-based complementary resistive switches by a physics-based memristive model (2014)

Highly predictive memristive models of resistive switches are required to simulate the behavior of anti-serially connected resistive switches, so called complementary resistive switches (CRSs). As an emerging non-volatile device suited for ultra-dense memory architectures, CRS cells offer great potential also as content addressable memories. Here, we introduce a circuit model for TaO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</inf> -based resistive switches which we implemented in VerilogA. This model is capable of predicting CRS behavior correctly.
Acute expansion of an asymptomatic posterior communicating artery aneurysm resulting in oculomotor nerve palsy (2013)

Acute expansion of an intracranial aneurysm is an extremely rare event. In this report, we describe the unusual radiographic documentation of acute expansion of a posterior communicating artery (PCOM) aneurysm from 4 to 8 mm, resulting in complete oculomotor nerve palsy. A 40-year-old man was admitted to our institution with a 3-week history of persistent occipital headaches but was otherwise neurologically intact. CT angiography demonstrated a 4 mm left PCOM aneurysm. Digital subtraction angiography performed several hours following presentation demonstrated an expansion in aneurysm size to 8 mm with new-onset complete oculomotor nerve palsy. The aneurysm was successfully obliterated by clip ligation. Although growth in aneurysm size is often a progressive phenomenon, acute expansions of aneurysms can occur.
Monitoring Molecular Aging of Lens Proteins using Noninvasive Quasi-Elastic Light Scattering (2015)

Post-translational modifications of lens proteins during aging can be monitored with quasi-elastic light scattering. Here, we show the ability of the technique to detect these changes both in vitro and in vivo.
Image segmentation for measuring growth coefficients of wheat used in precision agriculture (2022)

Water deficit affects several physiological variables of the plant and is synonymous with a decrease in yield and quality for field crops such as wheat. Irrigation is therefore a recommended solution. Agronomic image processing has enabled the development of several tools to deal with the phenomenon, by combining sensors and models such as the percentage of soil cover PGC and crop coefficient Kc. The aim of our work is the development of an indicator of the condition of the crop plants, accessible by video surveillance using image segmentation based on the multiphase level set model, allowing the early detection and prevention of water stress. Repeated images were taken on control plants at several stages of crop development.
THE EPIDERMAL PROLIFERATIVE UNIT: THE POSSIBLE ROLE OF THE CENTRAL BASAL CELL (1974)

ABSTRACT A model is suggested for the organization of the epidermis based on the ordered structure of the differentiating layers, as demonstrated by published work. This ordered structure enables one to look through the epidermis at the basal cell nuclei and to see their arrangement beneath the differentiating column of cells. In dorsal skin from male DBA‐2 mice there are 10.6 basal nuclei beneath a column of cells. The central nucleus of the group responds slightly earlier and more effectively than the rest to stimulation, is cycling more slowly than the majority of the basal nuclei and may spend significant periods of time out of cycle. The skin appears to contain a series of fairly independent proliferative units, each of which contain ten or eleven basal nuclei and eight to ten superficial cells of which only the youngest one or two retain their nuclei. At the centre of each group of basal nuclei is a cell that behaves differently from the rest and which is present in the skin in numbers compatible with the number of clonogenic cells. It is suggested that this represents the basic stem cell of the unit.
Quantum state diffusion and time correlation functions (1996)

Abstract In computing the spectra of quantum mechanical systems one encounters the Fourier transforms of time correlation functions, as given by the quantum regression theorem for systems described by master equations. Quantum state diffusion (QSD) gives a useful method of solving these problems by unravelling the master equation into stochastic trajectories; but there is no generally accepted definition of a time correlation function for a single QSD trajectory. In this paper we show how QSD can be used to calculate these spectra directly; by formally solving the equations which arise, we arrive at a natural definition for a two-time correlation function in QSD, which depends explicitly on the stochastic noise of the particular trajectory, and which agrees in the mean with the ensemble average definition of correlation functions.
Quels sont les liens entre arithmétique et langage ? Une étude en Amazonie. (2007)

http://www.editionsdelherne.com/
Novel Capture Processes (2005)

Six widely differing, novel capture processes, currently under development in Europe are described. These processes cover the range of postcombustion, precombustion and denitrogenation and show favourable possibilities for integration with power plants. They can be regarded as potential break-throughs in technical performance and/or costs.
Detection of Polynitro Compounds at Low Concentrations by SERS Using Ni@Au Nanotubes (2022)

The identification of high-energy compounds in trace concentrations not only in the laboratory, but also in field conditions is of particular interest. The process should be clear, easy, and well-recognizable. We formed SERS-active substrates by using elongated nickel nanotubes synthesized by electrochemical deposition in the pores of ion-track membranes and coated them with gold for further application in the detection of low concentrations of analytes. The substrates were characterized using various techniques to determine the morphology of the nanotubes and modifying gold layer. The possibility of obtaining two types of gold-layer morphology was shown: in the form of a smooth film up to 20–50 nm thick and a coating with nanoneedles up to 250 nm long. The electric fields around the nanotubes were simulated at a laser wavelength of 532 nm to demonstrate the influence of the gold-layer morphology on the field distribution. The “needle” morphology was chosen to form the most effective SERS-active substrates for detection of low concentrations of aromatic polynitro compounds. The spectral peaks were identified by comparing the model and experimental Raman spectra at concentrations down to 10−5 M. Within this limit, all peaks (“fingerprints” of the substance) were clearly distinguishable.