gebhart/patrepeval huggingface dataset:
Mirror box therapy for complex regional pain syndrome (2006)

A 63-year-old woman presented with swelling and reduced range of movements in the right upper limb following a fracture of scaphoid bone. She was diagnosed with complex regional pain syndrome (CRPS I). Simple analgesics and neuropathic medications were of no benefit, and sympathetic blocks were equally ineffective. Following a study course at the International Association for the Study of Pain conference in Sydney, Australia, in 2005, she was commenced on mirror box therapy (Fig. 4), first described by Ramachandran in the treatment of phantom limb pain [1]. The patient had an immediate and dramatic improvement in the movement of the affected limb and reduction in pain scores of more than 50%. Following this trial in the outpatient department, she was then issued with a mirror box to take home. Mirror box in use. Ramachandran proposed in patients with phantom limb pain that there is disruption in the normal interaction between motor intention to move a limb and proprioceptive feedback. They speculated that visual feedback might interrupt this pathological cycle. Mirror box therapy for CRPS is thought to work by providing such a visual feedback: by moving the unaffected limb in front of the mirror there is cortical reorganisation of the sensory homunculus within the parietal cortex. Whether these changes in the cortex are a primary or secondary effect of CRPS is still unknown. Mirror box therapy may provide a quick, cheap, effective and relatively painless form of management for a condition that is very resistant to conventional therapeutic strategies.
Electric water heaters control strategy for providing regulation services and load leveling in electric power systems (2013)

To address variation in renewable power generation and electricity demand, this paper presents a new control strategy of thermal loads. Electric water heaters decrease or increase their power consumption for up and down regulations associated to wind power output. The control technique determines the current regulation level that represents the active position of the aggregate with respect to time dependent regulation capacity. Using the temperatures distribution of the loads, the control technique calculates a reference temperature that corresponds to regulation signal. The temperatures distribution can be obtained by real time data made possible by advanced metering and communication technologies or it can be estimated using probabilistic approaches. Loads with temperatures situated in the same temperature range consume the same amount of power by modulating their electricity demand using voltage controller. The results show how the power consumption of aggregated loads follows regulation signals by slightly varying the reference temperature. Higher reference temperature variation allows lowering peak demand while offering minute-to-minute regulations. Also, the results show the evolution of the current regulation level that represents the active position of the aggregate with respect to time dependent regulation capacity.
Identification, Recombinant Expression, and Characterization of the 100 kDa High Molecular Weight Hymenoptera Venom Allergens Api m 5 and Ves v 3 (2010)

Insect stings can cause life-threatening IgE-mediated anaphylactic reactions in venom-allergic patients. Although several compounds have already been described as venom allergens, prominent allergen candidates especially in the higher m.w. range have still remained elusive. Tandem mass spectrometry-based sequencing assigned a candidate gene to the most prominent putative high m.w. allergen Api m 5 (allergen C) in honeybee (Apis mellifera) venom and also allowed identification of its homologue Ves v 3 in yellow jacket (Vespula vulgaris) venom. Both proteins exhibit a pronounced sequence identity to human dipeptidyl peptidase IV or CD26. Reactivity of a human IgE mAb verified the presence of these proteins in the venoms. Both proteins were produced in insect cells and characterized for their enzymatic activity as well as their allergenic potential using sera and basophils from insect venom-allergic patients. Both Api m 5 and Ves v 3 were recognized by specific IgE of the majority of patients even in the absence of cross-reactive carbohydrate determinants. Serologic IgE reactivity closely matched activation of human basophils by Api m 5 or Ves v 3, thus underlining their relevance in functional assays. With Api m 5 and Ves v 3, a new pair of homologous allergens becomes available for future clinical applications in diagnosis and therapy that may also contribute to the understanding of molecular mechanisms of insect venoms. Moreover, the patient IgE reactivity together with the cellular activation demonstrates for the first time the relevance of high m.w. allergens in the context of hymenoptera venom allergy.
Impact of Routine Screening for Adenocarcinoma of the Prostate on Stage Distribution (1987)

The impact of routine screening with digital rectal examination for carcinoma of the prostate on stage distribution of the disease was assessed in the primary treatment population of our medical center. Two, 5-year periods were compared: 1974 to 1978--before the onset of routine screening and 1979 to 1983--during the period of routine screening of this population. The clinical stage distribution of prostatic cancer before the onset of routine screening was not significantly different from national averages. Routine screening during the latter period significantly increased the percentage of patients with clinically curable carcinoma of the prostate. Pathologically, the disease was upstaged in many patients in both series. Digital rectal examination can have a significant impact on early detection of carcinoma of the prostate within a given population but it cannot be interpreted as a panacea for this disease.
Tregitopes: The active ingredient in IVIG-mediated tolerance induction? (P5224) (2013)

Abstract In the course of screening IgG sequences for T cell epitopes, we identified Treg epitope peptides, now called Tregitopes, contained in conserved framework regions of Fab and Fc. Tregitopes may provide one explanation for the expansion and stimulation of Treg following intravenous immunoglobulin (IVIg) therapy. Their distinguishing characteristics include in silico signatures of high-affinity binding to multiple human HLA class II DR, and conservation across IgG isotypes as well as mammalian species. Tregitopes induce expansion of CD4+/CD25hi/FoxP3+ T cells and suppress immune responses to co-incubated antigens in vitro. Comparing human Tregitopes (hTregitopes) to murine sequences, we identified class II-restricted murine Tregitope homologs (mTregitopes). We provide evidence that when APCs present Tregitopes to natural (n) Treg, APC expression of MHC II, CD80, and CD86 are decreased. Moreover, Tregitopes increase proportions of IL-10-producing nTreg. We propose the mechanism of Tregitope-mediated tolerance induction to be as follows: 1) APC present Tregitopes to nTreg, 2) nTreg are activated, proliferate and produce IL-10, 3) nTreg provide tolerogenic feedback signals to APC, modulating the APC phenotype, and 4) nTreg and tolerogenic APC together suppress antigen-specific T cell responses. The discovery of Tregitopes in IgG and other autologous proteins may lead to the development of new insights as to the role of Tregs in autoimmune diseases.
Multiple Folding Pathways for the P4−P6 RNA Domain (2000)

We recently described site-specific pyrene labeling of RNA to monitor Mg(2+)-dependent equilibrium formation of tertiary structure. Here we extend these studies to follow the folding kinetics of the 160-nucleotide P4-P6 domain of the Tetrahymena group I intron RNA, using stopped-flow fluorescence with approximately 1 ms time resolution. Pyrene-labeled P4-P6 was prepared using a new phosphoramidite that allows high-yield automated synthesis of oligoribonucleotides with pyrene incorporated at a specific 2'-amino-2'-deoxyuridine residue. P4-P6 forms its higher-order tertiary structure rapidly, with k(obs) = 15-31 s(-1) (t(1/2) approximately 20-50 ms) at 35 degrees C and [Mg(2+)] approximately 10 mM in Tris-borate (TB) buffer. The folding rate increases strongly with temperature from 4 to 45 degrees C, demonstrating a large activation enthalpy DeltaH(double dagger) approximately 26 kcal/mol; the activation entropy DeltaS(double dagger) is large and positive. In low ionic strength 10 mM sodium cacodylate buffer at 35 degrees C, a slow (t(1/2) approximately 1 s) folding component is also observed. The folding kinetics are both ionic strength- and temperature-dependent; the slow phase vanishes upon increasing [Na(+)] in the cacodylate buffer, and the kinetics switch completely from fast at 30 degrees C to slow at 40 degrees C. Using synchrotron hydroxyl radical footprinting, we confirm that fluorescence monitors the same kinetic events as hydroxyl radical cleavage, and we show that the previously reported slow P4-P6 folding kinetics apply only to low ionic strength conditions. One model to explain the fast and slow folding kinetics postulates that some tertiary interactions are present even without Mg(2+) in the initial state. The fast kinetic phase reflects folding that is facilitated by these interactions, whereas the slow kinetics are observed when these interactions are disrupted at lower ionic strength and higher temperature.
Incremental maintenance of recursive views using relational calculus/SQL (2000)

Views are a central component of both traditional database systems and new applications such as data warehouses. Very often the desired views (e.g. the transitive closure) cannot be defined in the standard language of the underlying database system. Fortunately, it is often possible to incrementally maintain these views using the standard language. For example, transitive closure of acyclic graphs, and of undirected graphs, can be maintained in relational calculus after both single edge insertions and deletions. Many such results have been published in the theoretical database community. The purpose of this survey is to make these useful results known to the wider database research and development community. There are many interesting issues involved in the maintenance of recursive views. A maintenance algorithm may be applicable to just one view, or to a class of views specified by a view definition language such as Datalog. The maintenance algorithm can be specified in a maintenance language of different expressiveness, such as the conjunctive queries, the relational calculus or SQL. Ideally, this maintenance language should be less expensive than the view definition language. The maintenance algorithm may allow updates of different kinds, such as just single tuple insertions, just single tuple deletions, special set-based insertions and/or deletions, or combinations thereof. The view maintenance algorithms may also need to maintain auxiliary relations to help maintain the views of interest. It is of interest to know the minimal arity necessary for these auxiliary relations and whether the auxiliary relations are deterministic. While many results are known about these issues for several settings, many further challenging research problems still remain to be solved.
Identification of cucurbitacins and assembly of a draft genome for Aquilaria agallocha (2014)

This study is the first attempt to identify cucurbitacin E and I from in vitro agarwood and the first draft genome for any species of Aquilaria. The results of this study will aid in future investigations of secondary metabolite pathways in Aquilaria and other non-model medicinal plants.
L-Ascorbic Acid Stimulates Expression of Smooth Muscle-Specific Markers in Smooth Muscle Cells both In Vitro and In Vivo (2003)

The dedifferentiation of vascular smooth muscle cells (VSMCs) plays a critical role in the progression of atherosclerosis and restenosis after angioplasty. Thus, factors that stimulate smooth muscle cell differentiation should be useful for therapy for these diseases. Previously, we found that l-ascorbic acid (L-Asc) induces the expression of smooth muscle-specific genes in a pluripotent bone marrow stromal cell line, TBR-B. This finding suggests that l-Asc stimulates the differentiation of smooth muscle cells. In the present study, we investigated the effects of l-Asc and its derivatives on the differentiation state of VSMCs in vitro and in vivo. l-Asc and its long-lasting derivatives stimulated the production of smooth muscle-specific myosin heavy chain-1 (SM1) and calponin 1 in a dose-dependent manner in rat cultured VSMCs, and the elevated production of SM1 and calponin 1 was maintained for at least 2 weeks. Moreover, oral administration of 3 g/kg of l-Asc to the balloon-injured rats induced a higher expression of SM1 and calponin 1 in the injured arteries compared with that from administration of the delivery vehicle alone. These data demonstrated new biologic activity, such as the stimulation of VSMC differentiation, of l-Asc and its long-lasting derivatives. In addition, these compounds may serve as useful tools for analysis of the differentiation of VSMCs and for therapy for vascular diseases.
Gallium and indium complexes with new hexadentate bis(semicarbazone) and bis(thiosemicarbazone) chelators (2021)

The synthesis of two new hexadentate potentially tetra-anionic acyclic chelators, an N2O4-donor bis(semicarbazone) (H4bsc) and an N2O2S2-donor bis(thiosemicarbazone) (H4btsc), is described. Coordination reactions of the ligands with gallium and indium precursors were investigated and yielded the complexes [Ga(Hbsc)] (1) and [In(Hbtsc)] (2), respectively. Ligands and complexes structures were confirmed by several techniques, including FTIR, NMR (1H, 13C, COSY, HSQC), ESI(+)-MS and single crystal X-ray diffraction analysis. The radioactive congeners [67Ga(Hbsc)] (1*) and [111In(Hbtsc)] (2*) were also synthesized and their radiolabeling yield and radiochemical purity were certified by HPLC and ITLC analyses. Biodistribution assays in groups of CD-1 mice showed a high uptake of both radiocomplexes in liver and intestine where 1* presented higher retention. In vitro and in vivo assays revealed higher stability of 1* compared with 2*, namely in the blood. The results suggest that radiocomplex 1* is a candidate for further investigation as it could be prepared in high yields (>95%), at low temperature (20-25 °C) and at fast reaction time (15 min), which are very desirable synthesis conditions for potential new radiopharmaceuticals.
Robot-Assisted Laparoscopic Partial Nephrectomy: The NYU Technique (2005)

The introduction of the daVinci surgical system has changed the way both surgeon and patient view radical prostatectomy. We hypothesized that the same theoretical and tangible benefits may be realized when employing the system for partial nephrectomy. This paper reviews our technique of robot-assisted laparoscopic partial nephrectomy (RALPN) utilizing the daVinci surgical system. Intraoperative hilar clamping is utilized in all cases. With the daVinci system, the tumor is excised with cold scissors, biopsies are taken from the base for frozen-section study, sutures are placed at the base, Gelfoam/fibrin glue is activated in the defect, a Surgicel bolster is laid in the defect, and mattress sutures are placed prior to releasing the clamp. After performing 12 RALPNs, it appears this technique is safe, feasible, and reproducible both for small exophytic masses and for deeper lesions involving the collecting system. A RALPN requires two surgeons, both well versed in laparoscopic and robotic techniques.
Electrochemical synthesis of highly ordered magnetic multilayered nanowire arrays (2012)

Electrochemical deposition is a versatile technique that has been employed to synthesize various types of onedimensional nanostructures such as nanorods, nanotubes and nanowires to meet different requirements for applications. Magnetic nanowires in the form of multilayered structures, such as Co/Cu and permalloy (Ni80Fe20)/Cu, with ferromagnetic materials alternating with non-magnetic materials exhibit giant magnetoresistance (GMR) property that can be utilized in sensors and mass memory devices. This study focuses on the synthesis of highly ordered magnetic multilayered nanowire arrays using template-directed electrochemical deposition technique. The nanowires were electrodeposited within the nanopores of anodized alumina from sulphate baths via pulse potential technique. The structures and compositions of the wires were characterized using various microscopy and probe-based techniques. Magnetoresistance measurement was performed on the multilayered nanowire arrays.
Facile Quantitative Analysis of Hydroxyl End Groups of Poly(2,6-dimethyl-1,4-phenylene oxide)s by 31P NMR Spectroscopy (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile Quantitative Analysis of Hydroxyl End Groups of Poly(2,6-dimethyl-1,4-phenylene oxide)s by 31P NMR SpectroscopyK. P. Chan, D. S. Argyropoulos, D. M. White, G. W. Yeager, and A. S. HayCite this: Macromolecules 1994, 27, 22, 6371–6375Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://doi.org/10.1021/ma00100a021RIGHTS & PERMISSIONSArticle Views357Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (526 KB) Get e-Alertsclose Get e-Alerts
L'idéologie de guerre sainte dans le haut Moyen Âge hispanique (2018)

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QUANTITATIVE STRUCTUREACTIVITY RELATIONSHIPS TO PREDICT IN VITRO TEAC AND EC50 OF SYNTHETIC ANILINES (2010)

Las relaciones cuantitativas actividadestructuraQSAR son utiles para entender la forma en que la estructura quimica de sustancias sinteticas y naturales se relaciona con la actividad biologica y para el diseno de nuevos y mejores compuestos en el presente estudio fueron evaludas las capacidades de 22 anilinas Narylmetil sustituidas para la captura de los radicales ABTS acido 22difenilpicrihidracilo relacionadas con los valores de TEACmmol troloxmmol antioxidante capacidad antioxidante equivalente al trolox y EC50 concentracion equivalente de antioxidante para disminuir la concentracion inicial de DPPH en un 50 respectivamente Las TEAC las EC50 y los descriptores teoricos derivados de las estructuras moleculares optimizadas fueron utilizados para elaborar las diferentes QSAR Los modelos TEAC con descriptores como EE energia electronica PPSA2carga total pesada con el area superficial cargada positivamente y a zzpolarizabilidad exacta mostraron una capacidad de prediccion satisfactoria por procedimientos de validacion interna y externa por lo que pueden ser utiles para la prediccion de actividades de compuestos que aun no han sido sintetizados o con datos experimentales no disponibles
Fractals in Microcavities: Giant Coupled, Multiplicative Enhancement of Optical Responses (1999)

A novel class of optical materials, microcavities doped with nanostructured fractal aggregates, was studied. Fractal aggregate optical excitations may be concentrated in regions smaller than the diffraction limit of conventional optics, resulting in large local fields. Seeding the aggregates into microcavities further increases the local fields because of light trapping by microcavity resonance modes. These microcomposites possess unique optical properties, including very large probabilities of radiative processes. In our experiments, lasing at extremely low pump intensities, below 1 mW, and strongly enhanced Raman scattering was observed in fractal-microcavity-dye composites.
Global Conservation for Wandering Wildlife (1983)

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Immunobiotic Lactobacillus jensenii TL2937 Alleviates Dextran Sodium Sulfate-Induced Colitis by Differentially Modulating the Transcriptomic Response of Intestinal Epithelial Cells (2020)

Immunobiotics have emerged as a promising intervention to alleviate intestinal damage in inflammatory bowel disease (IBD). However, the beneficial properties of immunobiotics are strain dependent and, therefore, each strain has to be evaluated in order to demonstrate its potential application in IBD. Our previous <i>in vitro</i> and <i>in vivo</i> studies demonstrated that <i>Lactobacillus jensenii</i> TL2937 attenuates gut acute inflammatory response triggered by Toll-like receptor 4 activation. However, its effect on colitis has not been evaluated before. In this work, we studied whether the TL2937 strain was able to protect against the development of colitis in a dextran sodium sulfate (DSS)-induced mouse model and we delved into the mechanisms of action by evaluating the effect of the immunobiotic bacteria on the transcriptomic response of DSS-challenged intestinal epithelial cells. <i>L. jensenii</i> TL2937 was administered to adult BALB/c mice before the induction of colitis by the administration of DSS. Colitis and the associated inflammatory response were evaluated for 14 days. Mice fed with <i>L. jensenii</i> TL2937 had lower disease activity index and alterations of colon length when compared to control mice. Reduced myeloperoxidase activity, lower production of pro-inflammatory (TNF-α, IL-1, CXCL1, MCP-1, IL-15, and IL-17), and higher levels of immunoregulatory (IL-10 and IL-27) cytokines were found in the colon of TL2937-treated mice. In addition, the treatment of porcine intestinal epithelial (PIE) cells with <i>L. jensenii</i> TL2937 before the challenge with DSS differentially regulated the activation of the JNK pathway, leading to an increase in epithelial cell integrity and to a differential immunotranscriptomic response. TL2937-treated PIE cells had a significant reduction in the expression of inflammatory cytokines (<i>TNF</i>-α, <i>IL-1</i>α, <i>IL-1</i>β, <i>IL-6, IL-15</i>), chemokines (<i>CCL2, CCL4, CCL8, CXCL4, CXCL5, CXCL9, CXCL10</i>), adhesion molecules (<i>SELE, SELL, EPCAM</i>), and other immune factors (<i>NCF1, NCF2, NOS2, SAA2</i>) when compared to control cells after the challenge with DSS. The findings of this work indicate that (a) <i>L. jensenii</i> TL2937 is able to alleviate DSS-induced colitis suggesting a potential novel application for this immunobiotic strain, (b) the modulation of the transcriptomic response of intestinal epithelial cells would play a key role in the beneficial effects of the TL2937 strain on colitis, and (c) the <i>in vitro</i> PIE cell immunoassay system could be of value for the screening and selection of new immunobiotic strains for their application in IBD.