gebhart/patrepeval huggingface dataset:
Role of transcranial direct current stimulation (TDCS) intervention on resting state functional connectivity in early Alzheimer’s disease (2021)

Abstract Background Working memory and executive function deficits are the characteristic features of Mild Cognitive Impairment and mild Alzheimer’s Disease (mild AD). Studies exploring the alterations in working memory and executive functions show disrupted functional connectivity in Dorsolateral Pre Frontal Cortices (DLPFC) and Angular Gyrus (AG). Transcranial direct current stimulation (tDCS), by stimulating these brain regions, can alter resting‐state functional connectivity (rs‐FC) and has emerged as a safe and non‐invasive technique that has the potential to enhance neuroplasticity and cognitive improvement. Method We investigated the effect of anodal stimulation at the left DLPFC and cathode placed at the right supra‐orbital area to observe the rsFC changes in patients with MCI and mild AD (n=12; Age=67.58 ± 8.59 years, Gender ratio 1:1, formal years of education= 14.58±3.55 years, Hindi mental Status examination=26.91±3.1), who attended the outpatient services of Geriatric Clinic and Services, after due approval from institute ethics committee NIMHANS. The resting‐state functional magnetic resonance imaging (rsfMRI) acquisitions were performed before and after the ten sessions of tDCS, each session lasting 20 minutes. Investigations were performed on subregions of DLPFC (left Superior Frontal Gyrus (LSFG), Right SFG, left Middle Frontal Gyrus (LMFG) and Right MFG) and Angular Gyrus (Right Angular Gyrus (RAG) and Left AG), chosen a priori as seeds for the seed based FC (sbFC) analysis after correcting for the influences of age and gender using CONN 18b toolbox. Spherical masks of size 5 mm diameter were also created for the above‐mentioned seeds. Result The pre‐post tDCS comparisons of sbFC showed significant (FDR; p&lt;0.05) reduction of rsFC in patients with MCI and mild AD at right supramarginal gyrus, right angular gyrus, right frontal pole (for Seed‐RAG, Voxel‐ whole brain), supramarginal gyrus (for Seed‐RAG, Voxel‐ RAG), and Middle Temporal gyrus, left Temporo‐Occipital part (for Seed‐ RSFG, Voxel‐ whole brain) as shown in Figure 1 a, b, and c respectively (Refer Table 1). Conclusion The results support that anodal stimulation using tDCS at left DLPFC may lead to the reduction of aberrantly increased functional connectivity between brain regions involved in working memory and executive functions in MCI and mild AD.
Inhibition of infection‐mediated preterm birth by administration of broad spectrum chemokine inhibitor in mice (2014)

Preterm birth (PTB) is the single most important cause of perinatal and infant mortality worldwide. Maternal infection can result in PTB. We investigated the ability of a Broad Spectrum Chemokine Inhibitor (BSCI) to prevent infection-induced PTB in mice. PTB was initiated in pregnant mice by intraperitoneal injection of lipopolysaccharide (LPS; 50 μg). Half the mice received BSCI (10 mg/kg) 24 hrs prior to and immediately before LPS administration. The impact of LPS alone or LPS plus BSCI was assessed on (i) injection-to-delivery interval, foetal survival rate, placental and neonates' weight; (ii) amniotic fluid and maternal plasma cytokine levels (by Luminex assay); foetal and maternal tissue cytokine gene expression levels (by Real-Time RT-PCR); (iii) immune cells infiltration into the uterine tissue (by stereological immunohistochemistry). Pre-treatment with BSCI (i) decreased LPS-induced PTB (64% versus 100%, P < 0.05); (ii) significantly attenuated cytokine/chemokine expression in maternal tissues (plasma, liver, myometrium, decidua); (iii) significantly decreased neutrophil infiltration in the mouse myometrium. BSCI-treated mice in which PTB was delayed till term had live foetuses with normal placental and foetal weight. BSCI represents a promising new class of therapeutics for PTB. In a mouse model of preterm labour, BCSI suppresses systemic inflammation in maternal tissues which resulted in the reduced incidence of LPS-mediated PTB. These data provide support for efforts to target inflammatory responses as a means of preventing PTB.
Translating genetic and preclinical findings into autism therapies (2017)

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social deficits and repetitive/restrictive interests. ASD is associated with multiple comorbidities, including intellectual disability, anxiety, and epilepsy. Evidence that ASD is highly heritable has spurred major efforts to unravel its genetics, revealing possible contributions from hundreds of genes through rare and common variation and through copy-number changes. In this perspective, we provide an overview of the current state of ASD genetics and of how genetic research has spurred the development of in vivo and in vitro models using animals and patient cells to evaluate the impact of genetic mutations on cellular function leading to disease. Efforts to translate these findings into successful therapies have yet to bear fruit. We discuss how the valuable insight into the disorder provided by these new models can be used to better understand ASD and develop future clinical trials.
Semantic Web Service Discovery and Selection: a Test Bed Scenario (2008)

Abstract. The Semantic Web Service Challenge is one of the major initiative dedicated to work on Semantic Web Service (SWS) discovery and selection. It represents an effective manner for evaluating the functionality of SWS technologies. In this paper, we provide a new SWS-Challenge scenario proposal with new interesting problems to be solved on the basis of an analysis of a real world shipment scenario in the logistic operators domain. In the discussion a number of aspects concerning the discovery and selection processes are emphasized. In particular, we focus on the problem of considering the heterogeneity between the provider and the requester perspectives, and on the differences between functional and non functional specifications both on the requester and provider side.
A Multivariate Model for Predicting Business Failures of Hospitality Firms (2000)

This study estimated a multivariate discriminant model for predicting hospitality firm bankruptcy. The model has a 93 per cent accuracy in classifying the in-sample firms into bankrupt and non-bankrupt firms. The model suggests that unprofitable firms burdened with debts, short-term debts in particular, are more likely to be candidates for bankruptcy. Fast expansion and sales growth of those firms may increase their bankruptcy likelihood.
Domain name based visualization of Web histories in a zoomable user interface (2002)

Users of hypertext systems like the World Wide Web (WWW) often find themselves following hypertext links deeper and deeper, only to find themselves "lost" and unable to find their way back to the previously visited pages. We have implemented a Web browser companion called Domain Tree Browser (DTB) that builds a tree structured visual navigation history while browsing the Web. The Domain Tree Browser organizes the URLs visited based on the domain name of each URL and shows thumbnails of each page in a zoomable window.
Tuba, a Novel Protein Containing Bin/Amphiphysin/Rvs and Dbl Homology Domains, Links Dynamin to Regulation of the Actin Cytoskeleton (2021)

Tuba is a novel scaffold protein that functions to bring together dynamin with actin regulatory proteins. It is concentrated at synapses in brain and binds dynamin selectively through four N-terminal Src homology-3 (SH3) domains. Tuba binds a variety of actin regulatory proteins, including N-WASP, CR16, WAVE1, WIRE, PIR121, NAP1, and Ena/VASP proteins, via a C-terminal SH3 domain. Direct binding partners include N-WASP and Ena/VASP proteins. Forced targeting of the C-terminal SH3 domain to the mitochondrial surface can promote accumulation of F-actin around mitochondria. A Dbl homology domain present in the middle of Tuba upstream of a Bin/amphiphysin/Rvs (BAR) domain activates Cdc42, but not Rac and Rho, and may thus cooperate with the C terminus of the protein in regulating actin assembly. The BAR domain, a lipid-binding module, may functionally replace the pleckstrin homology domain that typically follows a Dbl homology domain. The properties of Tuba provide new evidence for a close functional link between dynamin, Rho GTPase signaling, and the actin cytoskeleton.
Analysis of different PM machines with concentrated windings and flux barriers in stator core (2014)

The new stator structure with magnetic flux-barriers in the stator yoke or tooth region represents an efficient method for reducing the sub-harmonics of electric machines with fractional slots, tooth-concentrated windings. In this paper the both flux-barriers techniques are considered during the analysis of different PM machines. The 12-teeth single-layer and double-layer concentrated winding in combination with a 10-poles and 14-poles PM rotor are investigated. For the all machine topologies the new stator design is used to improve their performances and characteristics. The flux-barrier effects on the main machine parameters, such as in the air-gap flux density harmonics, dq-machine parameters, characteristic currents, electromagnetic torque, and so on, are studied carefully. Comparisons performed with the analogous conventional machines (with conventional stator) show that, the new stator design offers significant advantages.
Extrachromosomal circles of satellite repeats and 5S ribosomal DNA in human cells (2010)

These findings, and previous reports, support the general notion that every chromosomal tandem repeat is prone to generate eccDNA in eukryoric organisms including humans. They suggest the possible involvement of eccDNA in the length variability observed in arrays of tandem repeats. The implications of eccDNA on genome biology may include mechanisms of centromere evolution, concerted evolution and homogenization of tandem repeats and genomic plasticity.
The first synthesis of [9, amino-15N2] adenine and β-2′-deoxy-[9, amino-15N2] adenosine (1996)

β-2′-Deoxy-[9, Amino-15N2] Adenosine has been constructed in 4 steps from commercially available 5-amino-4,6-dichloropyrimidine and 15NH3. The reactions have been scaled to provide significant quantities of labeled nucleoside.
Physical and Antimicrobial Properties of Chitosan/Silver Nanoparticle Composite Hydrogels: Role of the Crosslinker (2022)

Chitosan hydrogels have widespread industrial applications due to their versatility and antimicrobial potential. However, their applicability can be limited by poor mechanical properties or because their fabrication requires the use of toxic compounds which can leach into their environment. Additionally, their poor water solubility under neutral conditions restricts their fabrication and applications to low pHs. Here, we synthesized a modified derivative [N-(2-hydroxy-3-trimethylammonium)propyl] chitosan chloride (HTCC), which is soluble and antimicrobial at neutral pH, and used it to compare the effect of three crosslinking agents on the formation of industrially relevant hydrogels. The crosslinkers sodium tripolyphosphate (TPP), glutaraldehyde (GA), and citric acid (CA) were compared in terms of their impact on the swelling potential, hydrophobicity, and mechanical properties. Swelling degrees ranging from 350 to 2350% for GA and TPP, respectively, were observed. Silver nanoparticles (Ag NPs) were synthesized in situ, leading to improved mechanical properties as evidenced by an increase in the Young modulus from 10.3 MPa for TPP-crosslinked systems to 87.4 MPa for TPP-crosslinked/Ag NP composites. Ag ion release rather than Ag NP leaching was determined to be the dominant strategy for antimicrobial action against Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Acinetobacter baumanii, causing significant increases (p < 0.05) in clearance ratios and biofilm shape factors, pointing to a synergism between the crosslinked HTCC and Ag NPs. The exceptional broad-spectrum antimicrobial/antifouling properties of these materials regardless of the crosslinking method allow for selection of different preparation techniques to tune desired traits for diverse industrial applications.
New Biologic Drugs: Anti-Interleukin Therapy (2012)

Interleukins (ILs) are cytokines which are defined by their capability to convey information between leukocytes, in this way directing proliferation, activation, and migration and also regulation of the cells. Data from anti-IL treatments in systemic autoimmune diseases have shown these drugs to be beneficial and to have a satisfactory safety profile and tolerance. Recent publications of small case series suggest that several anti-IL drugs have considerable efficacy in treating otherwise refractory uveitis. Anti-IL therapy, therefore, might constitute an option for the treatment of uveitis resistant to corticosteroids, classical immunosuppressives, or tumor necrosis factor-α inhibitors. However, due to high costs and possible long-term risks, anti-IL agents should currently be reserved to selected uveitis patients and be administered only under close interdisciplinary monitoring.
Novel host materials for blue phosphorescent OLEDs (2013)

We present two classes of host materials for blue phosphors. The first are carbazole substituted biphenyls 1-9. In these CBP-type materials the triplets are confined to one half of the molecules by using either twisted biphenyls or by a metalinkage of the carbazoles to the biphenyl. We obtained high triplet energies of 2.95-2.98 eV and high glass transition temperatures in the range of 100-120 °C. OLEDs were fabricated using the host material 6 and the carbene emitter Ir(dbfmi) with pure blue emission at 450 nm. The devices achieved an external quantum efficiency of 8.7% at 100 cd/m<sup>2</sup> and 6.1% at 1000 cd/m<sup>2</sup>. MBPTRZ with an electron transporting biscarbazolyltriazine that is separated from the hole transporting carbazole by a non-conjugated, meta-linked biphenyl unit is an example for a bipolar matrix material. The excellent glass forming properties and the high T<sub>g</sub> of 132 °C ensure morphological stability in OLEDs. The meta-linkage and the additional twist at the biphenyl unit, which is achieved by two methyl groups in the 2- and 2’-position of the biphenyl in MBPTRZ leads to a decoupling of the electron accepting and electron donating part and therefore to a high triplet energy of 2.81 eV. DFT calculations show a clear separation of the electron and hole transporting moieties. A phosphorescent OLED with MBPTRZ as host and FIrpic as emitter reached a maximum external quantum efficiency of 7.0%, a current efficiency of 16.3 cd/A and a power efficiency of 6.3 lm/W.
A wrist-mounted activity and pulse recording system (2003)

A wrist movement and arterial pulse recording system has been developed for continuous data acquisition in studies of activity/rest time periods, sleep quantity and quality, general activity level, resting heart rate and circadian rhythms. The system employs a wrist-mounted optical sensor, low-power 8-bit single chip microcomputer and a compact flash memory. The microcomputer detects whether the wrist is moving or inactive; if it is moving, activity signals are recorded by the compact flash memory. If the wrist is at rest, the arterial pulse waveform is continuously recorded.
Modern antenna design concepts for satellite and personal communications (2002)

The increasing demands placed upon antennas to provide wireless channels for satellite and personal communications systems has encouraged the development of sophisticated analysis and design techniques. This paper presents design concepts based upon recent advances associated with diffraction synthesis/analysis of dual offset reflector antennas for satellite communications as well as the application of the finite difference time domain (FDTD) approach for evaluating antennas for personal communications systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Mapping the game landscape: Locating genres using functional classification (2009)

Are typical computer game genres still valid descriptors and useful for describing game structure and game content?Games have changed from simple to complex and from single function to multi function.By identifying structural differences in game elements we develop a more nuanced model to categorized games and use cluster analysis as a descriptive tool in order to do so.The cluster analysis of 75 functionally different games shows that the two perspectives (omnipresent and vagrant), as well as challenges, mutability and savability are important functional categories to use in order to describe games.
The Effect of Serial Monolayer Passaging on the Collagen Expression Profile of Outer and Inner Anulus Fibrosus Cells (2006)

The differences in expression profiles of outer and inner anulus cells support previous findings that zonal differences exist between the cell types. Up to passage 2, both cell types were not significantly different from freshly isolated cells and maintained distinct phenotypic characteristics. However, after 6 sequential passages, outer and inner anulus cells became morphologically indistinguishable, and displayed no significant differences in collagen I gene and protein expression, thus becoming a more homogeneous population. As such, serial monolayer passaging has a marked effect on disc cell behavior, and is an important factor to consider when designing and evaluating in vitro studies and for potential cell-based therapies for disc repair.
Multilingual Sentiment Analysis: State of the Art and Independent Comparison of Techniques (2016)

With the advent of Internet, people actively express their opinions about products, services, events, political parties, etc., in social media, blogs, and website comments. The amount of research work on sentiment analysis is growing explosively. However, the majority of research efforts are devoted to English-language data, while a great share of information is available in other languages. We present a state-of-the-art review on multilingual sentiment analysis. More importantly, we compare our own implementation of existing approaches on common data. Precision observed in our experiments is typically lower than the one reported by the original authors, which we attribute to the lack of detail in the original presentation of those approaches. Thus, we compare the existing works by what they really offer to the reader, including whether they allow for accurate implementation and for reliable reproduction of the reported results.
Flow field design development using the segmented cell approach (2002)

We report on fuel cell flow-field development employing two-dimensional computational fluid dynamics (2-D CFD). Simulation of the flow distribution of a parallel channel flow-field, with a simple one-channel manifold, predicted inhomogeneous performance distribution within the cell. Further modeling, focusing on modification of the inlet and outlet flow fields, was used to predict a more homogeneous flow distribution in the flow-field. Attempts were made to verify the theoretical predictions experimentally by application of the segmented cell system. Measurements of the current distribution and CO transient response supported the 2-D CFD predictions. However, the margin of error between predicted and experimental results was considered insufficient to be of practical use. Future work will involve the evaluation of 3-D CFD to achieve the appropriate level of accuracy.
[Identification and susceptibility of clinically isolated yeast-like fungi]. (1990)

We studied the identification and susceptibility of clinically isolated yeast-like fungi at Showa University Hospital from April 1988 to March 1989. Clinically significant of yeast-like fungi were observed in 7.1% of specimens from outpatients, 13.0% of inpatients. In both outpatients and inpatients, yeast-like fungi were isolated mainly from sputum and urine. But, one third of them were considered as non-pathogenic and not identified. The species of isolates were, Candida albicans 57%, Candida tropicalis 14% and Candida glabrata 8% in both inpatients and outpatients, and these species shared most part. The isolation frequency of Candida parapsilosis was higher in blood and cerebrospinal fluid (CSF) specimen than the others. The susceptibility test by agar dilution method indicated most of the isolates were susceptible to Amphotericin B and Miconazole (MIC less than or equal to 25 micrograms/ml). There was no difference in MIC between predominantly isolated fungi and commonly isolated fungi. Notably, isolates from blood and CSF showed a significant high tolerance against Amphotericin B and Miconazole than from the other specimens. The MICs of Fluconazole were shown to be very high (greater than 100 micrograms/ml) in normal Sabouraud agar, were decreased dose-dependently by human sera in the medium. These findings indicated the component(s) of sera enhanced the anti-fungal activity of Fluconazole.
Ime Twin Opac (1996)

Vendor: IME Systems, Inc. 50 Congress Street, Suite 825 Boston, Massachusetts 02109 (617) 722-0808 Fax: (617) 722-9893 Demo Available: Yes Version: 1.4 Modules/Prices: TINLIB license for 4 users on a LAN, $27,250. Includes DOS Acquisitions, Serials, Cataloging, Circulation and Import/Export, and the GUI OPAC PRODUCT REQUIREMENTS Micro: 33 MHz 486+ PC with 4 MB of memory is recommended. Operating System: Windows 3.1+ LANs Supported: Novell and other NetBIOS LANs, TCP/IP Average EASE OF USE 1 2 3 4 5 6 7 Simple and Natural Dialog 5 Minimum User Memory Load 6 Consistency 6 Feedback 5 Shortcuts 4 Error Prevention 5 Overall Rating 5.3 FEATURES TWIN OPAC (TINLIB Windows OPAC) from IME Systems is a graphical user interface-based client product in a client/server environment that links to IME's DOS-based TINLIB (The Information Navigator for Libraries) system. The initial TWIN OPAC window, as shown in Figure 1, presents four large buttons to the user to commence a search: Title Search, Name Search, Subject Search, and Combination Search. A tool bar at the bottom of the screen displays oversize icons that allow the user to Backtrack, Return to Main Menu, Clear the search request, Print, Export, Next, Previous, and Help. When the icon is not a valid option, it is replaced by a light gray globe. Clicking on the Subject button opens a scrollable window that displays the subject headings to be found in the library's database--see Figure 2. This window also contains a area, found at the lower right of the window, that allows a user to enter a word or portion of the word. After entering the search request, the user clicks on the button and the software displays the closest possible matches. No indication of the number of titles associated with a particular subject heading is given. Double clicking on a heading will open up a List Titles window, which is scrollable. The user may also use Skip Search to move to a particular title in a more direct manner. This window also contains Information, located on the right side of the window. This box indicates the Entries in List, Estimated (number of) Entries, Current Position (in the list), and a Status bar which provides a graphical representation of the above numerical information. Double clicking on a title will display the full bibliographic record as seen in Figure 3. The information displayed in this window is formatted in two columns labeled Tag and Data. The data labels and variable text appear in black on a white background. Some of the data, e.g., authors, series, publisher, subject headings, have three carrots >>> at the end of the field, indicating that the data is hypertext. Double clicking on this field immediately takes the user to a display of that field, e. …