gebhart/patrepeval huggingface dataset:
Isolation and characterization of bis(2,6-diisopropylphenoxo)bis(4-pyrrolidinopyridine)oxotitanium: a mononuclear aryloxide compound containing a terminal titanium(IV)-oxo group (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation and characterization of bis(2,6-diisopropylphenoxo)bis(4-pyrrolidinopyridine)oxotitanium: a mononuclear aryloxide compound containing a terminal titanium(IV)-oxo groupJohn E. Hill, Phillip E. Fanwick, and Ian P. RothwellCite this: Inorg. Chem. 1989, 28, 18, 3602–3604Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/ic00317a041https://doi.org/10.1021/ic00317a041research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Using Lignin to Modify Starch-Based Adhesive Performance (2020)

Unmodified kraft lignin was used to create a starch-based adhesive via the Stein Hall process. Lignin up to 35 wt% was used in several formulations. Lignin was incorporated in both the carrier and slurry portions of the formulations and the effect on adhesive strength and water resistance was studied. The addition of lignin resulted in a significant increase in adhesive strength when the lignin was added solely to the slurry portion. When lignin was added solely to the carrier portion, the adhesive strength decreased. Other formulations, where lignin was present in both the carrier and slurry portions, showed moderate increases in adhesive strength. Finally, the addition of lignin increased the water-resistance of the adhesive bond in the paperboard.
Retracted on March 1, 2022 : Practical Secure OMP Computation and Its Application to Image Modeling (2018)

In this paper, we propose the secure computation of sparse coding based on a random unitary transform. Cloud computing is spreading to many application fields including services that use sparse coding. This situation raises many new privacy concerns. The proposed scheme provides a practical Orthogonal Matching Pursuit (OMP) algorithm that allows computation on encrypted signals. We prove, theoretically, that the proposal has exactly the same sparse coefficient estimation performance as the unencrypted variant of the OMP algorithm. We apply it to image modeling based on an image patch model. Finally, we demonstrate its performance on synthetic data and natural images.
Cux1 confers resistance to apoptotic cell death in liver cancer cells (2016)

Background and Aims: CUX1 (CUTL1) is a transcription factor able to promote the expression of several genes implicated in cellular proliferation, differentiation and demise. In normal adult cells, it preferentially favors the expression of proapoptotic genes. Its aberrant expression in tumor turns its role as foe. Here, we analyze CUX1 activity in TRAIL (Tumour necrosis factor related apoptosis inducing ligand) mediated cell death in liver cancer cells.
PLL-Technik in der Praxis (1978)

Nach Darlegung der allgemeinen Grundlagen eines PLL-Systems soll nun in dem folgenden Kapitel auf die Anwendung und Entwurf dieses Verfahrens näher eingegangen werden.
Synthesis of Pyrrolo[2,3-d]pyrimidines that are Structurally Related to Methylated Guanosines from tRNA and the Nucleoside Q Analogs, PreQ0and PreQ1 (1997)

Abstract The N-3- and N-2-methylated analogs of several 5-substituted 2 amino-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidin-4-ones were synthesized from 5-cyano-2,4-dichloro-7-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine (10). These compounds are analogs of nucleoside Q that are methylated in a manner similar to some of the naturally occurring methylated guanosines.
Carbon Electrode in Electroic Spark Discharge (1966)

The electro-discharging tests in air under repeating, continuous and impulsive discharges have been examined respectively on the carbon electrode made of the commercial carbon brush materials. Although the photomicrographs of the carbon electrode exposed to the stable discharge show a rather smooth fine surface, those of the carbon electrode exposed to the unstable discharge show an uneven rough surface and large craters.The larger the electric conductivity, the flexibility (flexural strength/Young's modulus), and the thermal shock resitivity (thermal conductivity x flexural strength/Young's modulus x thermal expansion coefficient) of the carbon electrode are, the smaller the consumption rate due to continuous discharge, the voltage change and the degree of stiort-circuit due to impusive discharge.It seems that the above mentioned physical properties of carbon electrode do not contribute separately but in combined form to the electro-discharging properties. These relations are discussed by using the dimensional analysis and the consumption resitivity has been deduced from thermal eqilibrium equation assuming that the consumption of electrode is due to only the thermal effect of electric discharge. The larger the consumption resitivity of carbon electrode is the smaller the consumtion rate due to continuous discharge and the degree of short-circuit due to impulsive discharge.
Letter from Incoming Editor in Chief of Molecular Medicine, Dr. Betty Diamond (2014)

s continuous commitment to provide an interface between basic
3D-SLIP steering for high-speed humanoid turns (2014)

This paper presents new methods to control humanoid turns while running, through the use of a 3D-SLIP template model with steering control. The work builds on a previous controller for straight-ahead running and describes the new methods that enable online humanoid steering for different speeds and turn rates. As opposed to previous research which has studied 3D-SLIP steering with a monopod model, motion optimization for the SLIP here enforces leg separation. This leg separation gives rise to body sway in forward running and allows the template to capture the unique roles that the inside and outside legs each play during a high-speed turn. The trajectory optimization approach for this template is given, and the resultant CoM trajectories are characterized. Modifications to a previous controller for straight-ahead running are shown to enable running turns in a simulated humanoid model. The methods allow the humanoid to change its turn rate and direction from step to step and enable execution of a high-speed turn with a radius that is one fourth that of a standard 400m track. A video attachment to this paper shows the humanoid turning while running at up to 4.0 m/s, and highlights its ability to maintain balance in spite of push disturbances.
Anti-inflammatory Thiazine Alkaloids Isolated from the New Zealand AscidianAplidiumsp.:  Inhibitors of the Neutrophil Respiratory Burst in a Model of Gouty Arthritis (2007)

Ascidiathiazones A (3) and B (4), two new tricyclic thiazine-containing quinolinequinone alkaloids, were isolated from the New Zealand ascidian Aplidium species. Both compounds inhibited the in vitro production of superoxide by PMA-stimulated human neutrophils in a dose-dependent manner with IC50 1.55 +/- 0.32 and 0.44 +/- 0.09 microM, respectively. In vivo inhibition of superoxide production by peritoneal neutrophils in a murine model of gout was observed for both compounds with oral doses of 25.6 micromol/kg. Ascidiathiazone A (3) was synthesized in four steps from 8-hydroxyquinoline-2-carboxylic acid.
Self‐Powered Tactile Sensor Array Systems Based on the Triboelectric Effect (2018)

Abstract With the arrival of intelligent terminals, tactile sensors which are capable of sensing various external physical stimuli are considered among the most vital devices for the next generation of smart electronics. To create a self‐powered tactile sensor system that can function sustainably and continuously without an external power source is of crucial significance. An overview of the development in self‐powered tactile sensor array system based on the triboelectric effect is systematically presented. The combination of multi‐functionalization and high performance of tactile sensors aimed at achieving highly comprehensive performance is presented. For the tactile sensor unit, a development is summarized based on the two primary modes which are vertical contact–separation and single‐electrode. For the pressure mapping array, the resolution is significantly enhanced by the novel cross‐type configuration based on the single‐electrode mode. Integrated with other mechanisms, the performance will be further elevated by broadening of the detect range and realizing of visualization of pressure imaging. Then, two main applications of human–machine interaction (HMI) and trajectory monitoring are comprehensively summarized. Finally, the future perspectives of self‐powered tactile sensor system based on triboelectric effect are discussed.
Is multidrug resistance relevant in breast cancer? (1991)

The multidrug resistance phenotype is associated with expression of P-glycoprotein (P-gp), an energy-dependent drug efflux pump. P-gp is expressed in several clinically resistant human cancers. This article discusses the evidence that P-gp expression may be implicated in the development of clinical drug resistance in patients with breast cancer.
Structural Characterization of Anion–Calcium–Humate Complexes in Phosphate‐based Fertilizers (2013)

Fertilizers based on phosphate-metal-humate complexes are a new family of compounds that represents a more sustainable and bioavailable phosphorus source. The characterization of this type of complex by using solid (31)P NMR in several fertilizers, based on single superphosphate (SSP) and triple superphosphate (TSP) matrices, yielded surprising and unexpected trends in the intensity and fine structure of the (31)P NMR peaks. Computational chemistry methods allowed the characterization of phosphate-calcium-humate complexes in both SSP and TSP matrices, but also predicted the formation of a stable sulfate-calcium-humate complex in the SSP fertilizers, which has not been described previously. The stability of this complex has been confirmed by using ultrafiltration techniques. Preference towards the humic substance for the sulfate-metal phase in SSP allowed the explanation of the opposing trends that were observed in the experimental (31)P NMR spectra of SSP and TSP samples. Additionally, computational chemistry has provided an assignment of the (31)P NMR signals to different phosphate ligands as well as valuable information about the relative strength of the phosphate-calcium interactions within the crystals.
Myopathic Complications of Medical Disease (2009)

Disorders of muscle may be primary or acquired secondary to an underlying medical condition. Clinical presentations range from asymptomatic elevations in creatine kinase to fatal rhabdomyolysis. Recognition of the underlying precipitant is imperative to effectively institute treatment for a potentially reversible process. The focus of this article is to review complications of systemic illness that result in signs and symptoms of muscle dysfunction. Myopathic complications of endocrinopathy, metabolic abnormalities, medications, critical illness, organ transplantation, infection, autoimmune conditions, malignancy, and toxin exposure are discussed, with an emphasis on the clinical features, electromyography, and muscle biopsy findings.
Production, characterization and use of monoclonal antibodies against the major extracellular human cysteine proteinase inhibitors cystatin C and kininogen (1988)

Murine monoclonal antibodies against the major cysteine proteinase inhibitors of human biological fluids, cystatin C and kininogen, were produced. The cystatin C antibody, HCC3, with a Ka of 2 x 10(7) l/mol, increased the inhibition of papain by cystatin C and was suitable for use in immunoblotting, immunohistochemistry and in the construction of a sensitive sandwich enzyme immunoassay for quantification of cystatin C. It recognized not only free cystatin C but also cystatin C in complexes with cysteine proteinases. The kininogen antibody, HK4, was directed against the third, cysteine proteinase inhibitory domain of the heavy chain of kininogen (Ka = 1 X 10(7) l/mol), but did not influence the papain inhibitory activity of kininogen. It reacted with free kininogen as well as kininogen in complex with cysteine proteinases. Both antibodies could be used for the production of specific immunosorbents.
A transcriptionally defective long terminal repeat within an endogenous copy of mouse mammary tumor virus proviral DNA (1988)

Mouse mammary tumor virus proviral DNA is endogenous to most inbred strains of mice but in many strains is not transcriptionally active. This inactivity may be due to defects in the proviruses themselves or to position effects mediated by DNA sequences flanking the proviral units. The transcriptional competence of long terminal repeats (LTRs) derived from endogenous proviral DNA at genetic loci Mtv-8, Mtv-9, and Mtv-17 of the C57BL/6 mouse strain was examined with a transient transfection assay in which gene expression was monitored by expression of chloramphenicol acetyltransferase. LTRs from Mtv-8 and Mtv-9 were able to direct glucocorticoid-induced chloramphenicol acetyltransferase expression in this assay, while the LTR from Mtv-17 was only about 5% as effective. Analysis of chimeric LTRs indicated that the glucocorticoid-inducible transcriptional enhancer element within the Mtv-17 LTR is active when linked to a functional promoter from Mtv-8, whereas the promoter from Mtv-17 is defective in directing hormone-induced gene expression, even when linked to the Mtv-8 glucocorticoid-responsive enhancer. The DNA sequence of transcriptional control regions of the LTRs of all three endogenous proviral units was determined; this analysis revealed that the source of the defect in Mtv-17 is a single G-to-A transition at position-75 with respect to the site of transcription initiation that resides within the previously defined binding site for the transcription factor nuclear factor 1. Competition experiments with a gel electrophoresis mobility shift assay indicated that the affinity of nuclear factor 1 for DNA derived from Mtv-17 is significantly less than for comparable sequences derived from Mtv-8.
Multiple forms of alkaline phosphatase from Escherichia coli cells with repressed and derepressed biosynthesis of the enzyme (1981)

Isolation of multiple forms of alkaline phosphatase from Escherichia coli cells with repressed and derepressed biosynthesis of the enzyme is reported. Three enzyme forms were isolated from cells with derepressed synthesis, and one form was isolated from cells with repressed enzyme synthesis. The multiple enzyme forms did not differ in pH optimum, thermostability, or the degree of inhibition with orthophosphate; however, they did differ in the relative rate of hydrolysis of different substrates. The addition of substrates to the cells during enzyme derepression resulted in changes of the ratio of the multiple forms.
Passive Visible To Infrared Transducer For Dynamic Infrared Image Simulation (1982)

A passive visible to infrared image transducer is described which, for the first time, allows practical simulation of high resolution dynamic infrared imagery. A theoretical performance analysis is presented which indicates that an MTF (modulation transfer function) of 50% at 5 cycles/mm is achievable with a time response of less than 20 msec and a required input power of less than 2 mW/cm2 per simulated degree AT. Experimental results on working devices are reported which match theoretical predictions. Successful simulation of high speed real-world infrared imagery is described. Suggestions for future work which should further enhance resolution and dynamic range are presented.
Defect properties andp-type doping efficiency in phosphorus-doped ZnO (2006)

Based on first-principles pseudopotential calculations, we investigated the electronic structure of various P-related defects in ZnO and the $p$-type doping efficiency for two forms of P dopant sources such as ${\mathrm{P}}_{2}{\mathrm{O}}_{5}$ and ${\mathrm{Zn}}_{3}{\mathrm{P}}_{2}$. As compared to N dopants, a substitutional P at an O site has a higher ionization energy of about 0.62 eV, which makes it difficult to achieve $p$-type ZnO. Under Zn-rich growth conditions, ${\mathrm{P}}_{\mathrm{O}}$ acceptors are compensated by dominant donors such as ${\mathrm{P}}_{\mathrm{Zn}}$, leading to $n$-type conduction. Although a ${\mathrm{P}}_{\mathrm{Zn}}\ensuremath{-}2{V}_{\mathrm{Zn}}$ complex, which consists of a substitutional P at a Zn antisite and two Zn vacancies, acts as an acceptor, the formation of Zn vacancies is more probable on going to O-rich conditions for the dopant source using ${\mathrm{P}}_{2}{\mathrm{O}}_{5}$. On the other hand, when ${\mathrm{Zn}}_{3}{\mathrm{P}}_{2}$ is used as the P dopant source, the ${\mathrm{P}}_{\mathrm{Zn}}\ensuremath{-}2{V}_{\mathrm{Zn}}$ complex is energetically more favorable and becomes the dominant acceptor under O-rich growth conditions.
Wide-field fluorescence lifetime imaging of cancer (2010)

Optical imaging of tissue autofluorescence has the potential to provide rapid label-free screening and detection of surface tumors for clinical applications, including when combined with endoscopy. Quantitative imaging of intensity-based contrast is notoriously difficult and spectrally resolved imaging does not always provide sufficient contrast. We demonstrate that fluorescence lifetime imaging (FLIM) applied to intrinsic tissue autofluorescence can directly contrast a range of surface tissue tumors, including in gastrointestinal tissues, using compact, clinically deployable instrumentation achieving wide-field fluorescence lifetime images of unprecedented clarity. Statistically significant contrast is observed between cancerous and healthy colon tissue for FLIM with excitation at 355 nm. To illustrate the clinical potential, wide-field fluorescence lifetime images of unstained ex vivo tissue have been acquired at near video rate, which is an important step towards real-time FLIM for diagnostic and interoperative imaging, including for screening and image-guided biopsy applications.
Improvement of Transmucosal Absorption of Peptide and Protein Drugs. (1999)

Peptide and protein drugs are becoming a very important class of therapeutic agents. However, the oral bioavailability of peptide and protein drugs is generally poor because they are extensively degraded by proteases in the gastrointestinal tract and impermeable through the intestinal mucosa. For systemic delivery of peptide and protein drugs, parenteral administration is currently required to achieve their therapeutic activities. However, these administration are poorly accepted by patients and may cause allergic reactions and serious side effects. Therefore, various approaches have been examined to overcome the delivery problems of these peptides when they administered orally. These approaches include (1) to use additives such as absorption enhancers and protease inhibitors, (2) to develop an administration method for peptides that can serve as an alternative to oral and injection administration, (3) to modify the molecular structure of peptide and protein drugs to produce prodrugs and analogues, and (4) to use the dosage forms to these peptide drugs. Of all these approaches, we demonstrated that transmucosal absorption of various peptides including insulin, calcitonin, tetragastrin and thyrotropin releasing hormone (TRH) could be improved by using these approaches. Therefore, these approaches may give us basic information to improve the transmucosal absorption of peptide and protein drugs.
Response of human coronary arteries to different mechanical conditions (2010)

The lack of reliable mechanical data on coronary arteries hampers the application of numerical models to vascular problems, and precludes physicians from knowing in advance the response of coronary arteries to the different interventions. In this work, the mechanical properties of human coronary arteries have been characterized. Whole samples from human right (RC) and left anterior descending (LAD) coronary arteries aged between 23 and 83 years have been studied by means of in-vitro tensile testing up to failure. Knowledge of the mechanical response of human coronary arteries could be applied to optimize the election of vascular grafts or to prevent arterial damage during angioplasty.
Real-time in-situ monitoring of electrotherapy process using electric pulse-induced acoustic tomography (EpAT) (2018)

The use of electrical energy in applying reversible or irreversible electropermobilization for biomedical therapies is growing rapidly. This technique uses an ultra-short and high-voltage electric pulse (&mu;s-to-nsEP) to improve the permeability of cell membranes, thus allowing drug delivery to the cytosol via nanopores in the membrane. Since the treatment subject varies in size, location, shape and tissue environment, it is necessary to visualize this mechanism by monitoring electric field distributions in real-time. Previous studies suggested various techniques for monitoring electroporation, however, none of these techniques are so far capable for real-time monitoring of the electric field. In this study, we propose an innovative real-time, monitoring technique of electric field distributions based on electric field-induced acoustic emissions. For the first time, we demonstrate the capability of an electric field that used in electrotherapy to induce acoustic waves, which can be suggested for realtime monitoring. We tested this technique by generating a variety of electric field distributions (&mu;s-to-nsEP with intensity up to 120V/cm) to energize two electrodes in a bi-polar configuration (d1&equals;100&mu;m and d2&equals;200&mu;m). The electric field transmits a short burst of ultrasonic energy. We used ultrasonic receivers for collecting acoustic signals around the subject under test. Acoustic signals were collected through different intensities of electric field distributions and repositioning the electric field from the receiver in 3D structure. An electric field utilized in electrotherapy produces high resolution images that directly can improve the efficiency of electrotherapy treatments in real-time.
Immobilized Enzymes (2002)

In this chapter, a brief kinetic treatment of immobilized enzymes is presented. Kinetic models for the three main types of enzyme reactors are presented, namely batch, plug-flow and continuous-stirred. The integrated version of the Michaelis–Menten model is used as the basis for model development for batch and plug-flow reactors.