gebhart/patrepeval huggingface dataset:
High-yield method for the preparation of anomalous water (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh-yield method for the preparation of anomalous waterS. B. Brummer, G. Entine, J. I. Bradspies, H. Lingertat, and C. LeungCite this: J. Phys. Chem. 1971, 75, 19, 2976–2980Publication Date (Print):September 1, 1971Publication History Published online1 May 2002Published inissue 1 September 1971https://pubs.acs.org/doi/10.1021/j100688a017https://doi.org/10.1021/j100688a017research-articleACS PublicationsRequest reuse permissionsArticle Views39Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Load-side Frequency Regulation with Limited Control Coverage (2017)

Increasing renewable energy increases uncertainty in energy systems. As a consequence, generator-side control for frequency regulation, impacted by the slow reaction of generators to meet urgent needs, may no longer suffice. With increasing integration of smart appliances which are able to sense, communicate and control, load-side control can help alleviate the aforementioned problem as it reacts fast and helps to localize disturbances. However, almost all existing methods for optimal load-side control require full information control coverage in the system. Framing the problem as an optimization problem and applying saddle-point dynamics, we obtain a control law that rebalances power and asymptotically stabilizes frequency after a disturbance. We generalize previous work to design a controller which only requires partial control coverage over all nodes, yet still achieves secondary frequency control. We verify these results via simulation.
Precision Fourier Transform Spectroscopy with Femtosecond Frequency Combs (2009)

Author Institution: Laboratoire de Photophysique Moleculaire, CNRS, Batiment 350, Universite Paris-Sud, 91405 Orsay cedex, France; Max Planck Institut fur Quantenoptik, Hans-Kopfermann-Str. 1, 85748 Garching, Germany
PicoGreen Assay of Circular DNA for Radiation Biodosimetry (2015)

We developed a simple, rapid and quantitative assay using the fluorescent probe PicoGreen to measure the concentration of ionizing radiation-induced double-stranded DNA (dsDNA) in mouse plasma, and we correlated this concentration with the radiation dose. With 70 μl of blood obtained by fingerstick, this 30 min assay reduces protein interference without extending sample processing time. Plasma from nonirradiated mice (BALB/c and NIH Swiss) was pooled, diluted and spiked with dsDNA to establish sensitivity and reproducibility of the assay to quantify plasma dsDNA. The assay was then used to directly quantify dsDNA in plasma at 0-48 h after mice received 0-10 Gy total-body irradiation (TBI). There are three optimal conditions for this assay: 1:10 dilution of plasma in water; 1:200 dilution of PicoGreen reagent in water; and calibration of radiation-induced dsDNA concentration through a standard addition method using serial spiking of samples with genomic dsDNA. Using the internal standard calibration curve of the spiked samples method, the signal developed within 5 min, exhibiting a linear signal (r(2) = 0.997). The radiation-induced elevation of plasma DNA in mice started at 1-3 h, peaked at 9 h and gradually returned to baseline at 24 h after TBI (6 Gy). DNA levels in plasma collected from mice 9 h after 0-10 Gy TBI correlated strongly with dose (r(2) = 0.991 and 0.947 for BALB/c and NIH Swiss, respectively). Using the PicoGreen assay, we observed a radiation dose-dependent response in extracellular plasma DNA 9 h after irradiation with an assay time ≤ 30 min.
"Dear, dearest Valentine" (1992)

T I N E (Correspondance dlAlphonse de Larnartine et de Valentine de Cessiat) Les lettres adresses par Lamartine a sa niece Valentine de Cessiat ont t l'objet d'une publication essentielle par le comte de Chastellier: Lamartine et ses nieces.Correspondance inditr
Простатическая интраэпителиальная неоплазия высокой степени как тканевой маркер выявления рака предстательной железы (2008)

High grade prostatic intraepithelial neoplasia (HPIN) is the most likely precursor of invasive prostate cancer. The natural biological behaviour of HPIN is yet poorly understood. The presence of high grade prostatic intraepithelial neoplasia on needle biopsy is strongly predictive of carcinoma. The identification of prostatic intraepithelial neoplasia in needle.
Cutaneous pain and detection thresholds to short CO2 laser pulses in humans: Evidence on afferent mechanisms and the influence of varying stimulus conditions (1988)

Pain and detection thresholds to short CO2 laser pulses were studied in healthy human subjects. Pain thresholds were significantly higher than detection thresholds in both hairy and glabrous skin; in the glabrous skin both thresholds were higher in the hairy skin. The range from detection threshold to pain threshold was larger in the glabrous skin. The minimal energy per surface area needed to produce any sensation (detection) or pain sensation decreased with increasing stimulus surface, and this spatial summation effect was to equal magnitude in the hairy and the glabrous skin. With decreasing stimulus pulse duration (from 45 to 15 msec) the detection and pain thresholds were elevated: this effect was stronger on pain thresholds. With increasing adapting skin temperature, less energy was needed to produce any sensation (detection) or pain sensation. The effect of adapting skin temperature was equal on pain and detection thresholds. The conduction velocity of fibers mediating laser evoked first sensations was in the thin fiber range (less than 10 msec), according to a reaction time study. The results suggest that short CO2 laser pulses produce both non-pain and pain sensations, but that both these sensations are based on the activation of the same primary afferent fiber population of slowly conducting nociceptive fibers. Central summation of primary afferent impulses is needed to elicit a liminal non-painful sensation, and an increased number of impulses in the same fibers produces pain.
Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β Fibrils (2020)

A BF<sub>3</sub>·OEt<sub>2</sub> catalyzed intramolecular Povarov reaction was used to synthesize 15 chromenopyridine fused thiazolino-2-pyridone peptidomimetics. The reaction works with several <i>O</i>-alkylated salicylaldehydes and amino functionalized thiazolino-2-pyridones, to generate polyheterocycles with diverse substitution. The synthesized compounds were screened for their ability to bind α-synuclein and amyloid β fibrils <i>in vitro</i>. Analogues substituted with a nitro group bind to mature amyloid fibrils, and the activity moreover depends on the positioning of this functional group.
Vibrational study of a well–barrier–well thiophene–based oligomer in relation to the effective π-conjugation length (1999)

We have studied the Fourier transform infrared (FTIR) and the Fourier transform Raman (FT-Raman) spectra of a new thiophene-based oligomer in neutral form. The compound has a well–barrier–well structure, where the well parts are two bithienyl end moieties and the barrier part is a vinylene fragment with a larger energy gap. Characteristic features are correlated with vibrational data of unsubstituted α-linked oligothiophenes and α,α′-dimethyl end-capped oligothiophenes to assess information about the effective conjugation length of this oligomer. The FTIR and FT-Raman spectra have also been theoretically calculated at the B3LYP/6-31G** and RHF/6-31G** levels, respectively, to propose a vibrational assignment for the main bands in the whole spectral range.
Pathways of Peptide Ion Fragmentation Induced by Vacuum Ultraviolet Light (2005)

One Hundred Fifty-Seven nm photodissociation of singly protonated peptides generates unusual distributions of fragment ions. When the charge is localized at the C-terminus of the peptide, spectra are dominated by x-, v-, and w-type fragments. When it is sequestered at the N-terminus, a- and d-type ions are overwhelmingly abundant. Evidence is presented suggesting that the fragmentation occurs via photolytic radical cleavage of the peptide backbone at the bond between the alpha- and carbonyl-carbons followed by radical elimination to form the observed daughter ions.
TaxoGen: Unsupervised Topic Taxonomy Construction by Adaptive Term Embedding and Clustering (2018)

Taxonomy construction is not only a fundamental task for semantic analysis of text corpora, but also an important step for applications such as information filtering, recommendation, and Web search. Existing pattern-based methods extract hypernym-hyponym term pairs and then organize these pairs into a taxonomy. However, by considering each term as an independent concept node, they overlook the topical proximity and the semantic correlations among terms. In this paper, we propose a method for constructing topic taxonomies, wherein every node represents a conceptual topic and is defined as a cluster of semantically coherent concept terms. Our method, TaxoGen, uses term embeddings and hierarchical clustering to construct a topic taxonomy in a recursive fashion. To ensure the quality of the recursive process, it consists of: (1) an adaptive spherical clustering module for allocating terms to proper levels when splitting a coarse topic into fine-grained ones; (2) a local embedding module for learning term embeddings that maintain strong discriminative power at different levels of the taxonomy. Our experiments on two real datasets demonstrate the effectiveness of TaxoGen compared with baseline methods.
[Vasoconstrictor responsiveness of rat basilar artery enhanced by simulated weightlessness]. (1999)

These results indicate that medium-term simulated weightlessness may result in an enhanced contractile responsiveness in rat basilar artery, and strongly support the hypothesis of cerebrovascular syncope-initiating mechanism.
Prevalence Estimates of Antibodies Towards Foot-and-Mouth Disease Virus in Small Ruminants in Uganda (2009)

Foot-and-mouth disease (FMD) is endemic in Uganda with control strategies focusing on vaccination of cattle, while small ruminants are largely ignored. In order for Uganda to establish effective control strategies, it is crucial that the epidemiology of the disease is fully understood. This study summarizes results of serological investigations of sheep and goats for antibodies to FMDV from four districts in 2006 following an FMD outbreak in the region and from an attempted comprehensive random sampling in two districts in 2007. Antibodies were quantified and serotyped using competitive ELISA for antibodies towards non-structural proteins (NSP) and structural proteins towards serotype O, and blocking ELISA for antibodies towards the seven serotypes of FMD virus (FMDV). In 2006, sheep and goats in Bushenyi and Isingiro districts were free from antibodies towards FMDV, while herds in Kasese and Mbarara districts excluding Kahendero village were all positive for antibodies towards NSP and SP-O. In 2007, mean prevalence estimates of antibodies towards FMDV NSP was 14% in goats and 22% in sheep in Kasese district, while Bushenyi was still free. The difference between these two districts probably reflects different levels of FMDV challenge attributed to the variation in exposure rates which again in part may be as a result of the differing husbandry practices. Contrary to 2006, with clear antibodies towards serotype O, the serotype-specificity of the antibodies was less clear in 2007, as antibodies towards both serotype O and SAT serotypes were identified. Our results show that goats and sheep are infected during FMD outbreaks, and that they may be useful for determining the serotype of FMD outbreaks in Uganda, if they are sampled shortly after an outbreak.
Therapeutic Rationale to Target Highly Expressed Aurora kinase A Conferring Poor Prognosis in Cholangiocarcinoma (2020)

<b>Background</b>: Cholangiocarcinoma is a highly lethal neoplasm for which the currently available chemotherapeutic agents are suboptimal. Numerous studies show that alterations in expression of genes related to mitotic spindle and mitotic checkpoint are involved in chromosomal instability and tumor progression in various malignancies. This study aimed to evaluate these genes in cholangiocarcinoma patients. <b>Material and methods</b>: Different public datasets were analyzed to examine the expression of 76 selected mitotic spindle checkpoint genes including Aurora Kinase A (AURKA) in cholangiocarcinoma. Afterwards, cell number counting, CCK-8 assay, and Caspase 3/7 assay were used to explore the antitumor effect of AURKA inhibitor Alisertib <i>in vitro</i>. In addition, xenograft model was used to evaluate the antitumor effect of Alisertib <i>in vivo</i>. Furthermore, siRNA mediated silencing of AURKA was used to verify the function of AURKA in cholangiocarcinoma. <b>Results</b>: Components of the mitotic spindle checkpoint, including AURKA, were broadly dysregulated in human cholangiocarcinoma. High AURKA mRNA expression was associated with poor survival in cholangiocarcinoma patients within different datasets. AURKA specific inhibitor Alisertib, inhibited cell growth, induced cell cycle arrest in G2/M phase, and promoted apoptosis in cholangiocarcinoma cell lines. Additionally, Alisertib also inhibited tumor growth in a cholangiocarcinoma xenograft mouse model. Furthermore, AURKA knockdown by siRNA recapitulated the antitumor effect of Alisertib. AURKA expression was also highly correlated with its interaction proteins Polo-like kinase 1(PLK1) and Targeting protein for xenopus kinesin-like protein2 (TPX2) in different cholangiocarcinoma datasets. <b>Conclusions</b>: Highly expressed AURKA confers poor outcomes in cholangiocarcinoma and may represent a rational therapeutic target.
Structure of neovasinone. A new .ALPHA.-pyrone plant growth regulator produced by the fungus, Neocosmospora vasinfecta E. F. Smith. (1987)

Neocosmospora vasinfecta E. F. Smith is a well-known pathogen which causes root-and fruit-rot and seedling damping-off in the Malvaceae, Leguminosae, Piperaceae, Cucurbitaceae, etc., including pepper, peanuts, soybeans, beans, -coconuts, Albizziac and others.1} In the course of a screening search for plant growth regulators in various fungi,2'3) we found that the culture filtrate of Neocosmospora vasinfecta E. F. Smith var. africana (von Arx) Cannonet Hawksworthcontained substances which accelerated the root elongation of lettuce seedlings. The activity in
GPU implementation of prior image constrained compressed sensing (PICCS) (2010)

The Prior Image Constrained Compressed Sensing (PICCS) algorithm (Med. Phys. 35, pg. 660, 2008) has been applied to several computed tomography applications with both standard CT systems and flat-panel based systems designed for guiding interventional procedures and radiation therapy treatment delivery. The PICCS algorithm typically utilizes a prior image which is reconstructed via the standard Filtered Backprojection (FBP) reconstruction algorithm. The algorithm then iteratively solves for the image volume that matches the measured data, while simultaneously assuring the image is similar to the prior image. The PICCS algorithm has demonstrated utility in several applications including: improved temporal resolution reconstruction, 4D respiratory phase specific reconstructions for radiation therapy, and cardiac reconstruction from data acquired on an interventional C-arm. One disadvantage of the PICCS algorithm, just as other iterative algorithms, is the long computation times typically associated with reconstruction. In order for an algorithm to gain clinical acceptance reconstruction must be achievable in minutes rather than hours. In this work the PICCS algorithm has been implemented on the GPU in order to significantly reduce the reconstruction time of the PICCS algorithm. The Compute Unified Device Architecture (CUDA) was used in this implementation.
Analysis of integrated quantum-well infrared photodetector and light-emitting diode for implementing pixelless imaging devices (1997)

The conversion of images into nonuniform distribution of the output current density in a multiple-quantum-well structure for an infrared pixelless imaging system is considered using an analytical device model. The nonuniform current, which reproduces the incident image, is converted back to a light-emitting diode emission image by the device considered here. The developed model takes into account transport processes responsible for the device operation. An explicit expression for the contrast transfer characteristic is derived as a function of the number of quantum wells (QWs) and the electron capture parameter. It is shown that the quality of the up-converted images (contrast and resolution) is improved with increasing number of QWs. The pixelless imaging devices under consideration can effectively convert long-wavelength infrared images into short-wavelength infrared or visible images with contrast transfer ratio close to unity.
Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel Transcript Features (2015)

Toxoplasma gondii is an important protozoan parasite that infects all warm-blooded animals and causes opportunistic infections in immuno-compromised humans. Its closest relative, Neospora caninum, is an important veterinary pathogen that causes spontaneous abortion in livestock. Comparative genomics of these two closely related coccidians has been of particular interest to identify genes that contribute to varied host cell specificity and disease. Here, we describe a manual evaluation of these genomes based on strand-specific RNA sequencing and shotgun proteomics from the invasive tachyzoite stages of these two parasites. We have corrected predicted structures of over one third of the previously annotated gene models and have annotated untranslated regions (UTRs) in over half of the predicted protein-coding genes. We observe distinctly long UTRs in both the organisms, almost four times longer than other model eukaryotes. We have also identified a putative set of cis-natural antisense transcripts (cis-NATs) and long intergenic non-coding RNAs (lincRNAs). We have significantly improved the annotation quality in these genomes that would serve as a manually curated dataset for Toxoplasma and Neospora research communities.
A single-input two-output feedback formulation for ANC problems (2001)

This paper explores inherent feedback limitations of active noise control in ducts by using a single-input, two-output framework and observing properties of closed-loop transfer functions. Performance is assessed using the plant and disturbance alignment angle. We show that the sound levels at the measurement microphone axe amplified when attenuating acoustic energy at the error microphone. We also show that the stability margins can be improved over feedforward control using measurements from two sensors.
Pervasive monitoring: appreciating citizen's surveillance as digital evidence in legal proceedings (2011)

Images or video streams, extracted from data acquired through surveillance systems and intended to be used as evidence in court, should have all attributes of conventional digital evidence, meaning that they should be admissible, authentic, reliable, complete and believable. This paper discusses the first three attributes that surveillance systems should comply with to be submitted as evidence in legal proceedings and it identifies some of the obstacles in the way through harmonization.\nThe focus is on data gathered from a range of ad hoc sources present at the scene of an incident, including smartphones and wireless sensor networks (used for safety, security or traffic management/environmental monitoring). New scenarios for crowd-sourced surveillance mediated by law enforcement supervision are further considered. Specific attention is brought to the compliance with privacy requirements that often condition the admissibility of the evidence.
The genetic origin of drug resistance in neoplasms: implications for systemic therapy. (1984)

Drug resistance continues to be a major factor in limiting the effectiveness of cancer chemotherapy. Evidence from a variety of sources implicates a genetic basis for most drug-resistant phenotypes. Assuming a random spontaneous origin for these resistant cells, it is possible to develop mathematical and computer-based models of the drug treatment of tumors. These can provide a more intuitive understanding of the basis of treatment success or failure. This in turn may lead to the development of more rational and effective treatment protocols. Studies of phenomena such as pleiotropic drug resistance are providing insights into how multiple levels of drug resistance occur and are yielding information on how certain types of drug resistance may be prevented or overcome.