gebhart/patrepeval huggingface dataset:
The safety and effect of chemotherapy with short hydration for urothelial cancer on patients’ quality of life (2016)

The short hydration gemcitabine and cisplatin regimen for patients with urothelial cancer was safe. Further, the outpatient chemotherapy was found not only to be safe, but also to have improved the patients' quality of life.
Seismic parameters for transversely isotropic media (1984)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1984Seismic parameters for transversely isotropic mediaAuthors: Bok Sub ByunBok Sub ByunArco Oil & Gashttps://doi.org/10.1190/1.1894120 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1894120FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1984ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1984 Pages: 856 publication data© 1984 Copyright © 1984 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 24 Mar 2005 CITATION INFORMATION Bok Sub Byun, (1984), "Seismic parameters for transversely isotropic media," SEG Technical Program Expanded Abstracts : 683-685. https://doi.org/10.1190/1.1894120 Plain-Language Summary PDF DownloadLoading ...
Challenges and opportunities in the bottom-up mechanochemical synthesis of noble metal nanoparticles (2020)

This review covers the fundamentals and recent developments on the mechanochemical synthesis of noble metal nanoparticles.
Permeabilization ofBeauveria bassianablastospores for in situ enzymatic assays (2003)

Vigorous agitation of an aqueous suspension of blastospores (BS) of Beauveria bassiana mixed with nine volumes of a 1:4 (v/v) mixture of toluene:ethanol (95%) for 10 min permits blastospore permeabilization. Agitation results in greater membrane permeabilization than heating blastospores in the presence of toluene:ethanol or the detergents Triton X-100, sodium dodecyl sulfate, hexadecyltrimethylammonium bromide and Brij-35. The β-galactosidase activity in permeabilized blastospores was determined with these methods. The effectiveness of permeabilization in detecting enzyme activity was assessed by comparison to whole BS lysates prepared by mechanical disruption and pressurized disruption of BS biomass. The toluene:ethanol method was applied to study the incorporation of (3)H-thymidine triphosphate into blastospore DNA. Whole BS permeabilization allows the examination of enzyme activity and DNA synthesis at a cellular level in this important mycoinsecticide.
Genetic polymorphisms of SCNA9 as predictive markers of oxaliplatin-induced neuropathy. (2012)

9073 Background: Oxaliplatin (OXL) is an active drug in digestive tumors. Oxaliplatin induced peripheral neuropathy (OIN) is the main dose limiting toxicity. Around 60-80% of patients developed a mild cold-induced neurotoxicity that used to disappear few days after but in 15% became a persistent neuropathy. The pathophysiology of oxaliplatin-induced neuropathy (OIN) remains unclear, preclinical studies suggest involvement of voltage Na channels. SCN9A gene codifies to Na channels α subunit highly expressed in nociceptive neurons. Mutations in SCN9A are involved in alterations in neuropatic pain perception. This study tried to identify if variants in SCN9A could be associated to a higher risk to OIN. Methods: Serum were obtained from 100 patients with digestive cancer (colorectal, gastric, pancreatic and bile duct) treated with OXL (adjuvant or advanced setting) in Infanta Sofía University Hospital. No diabetes or hypotiroidism were detected. Patients were divided in two groups according to the development of OIN: Arm A 50 patients diagnosed of grade 2-3 OIN after 6 courses and Arm B 50 with no OIN. The evaluation of severity of the OIN by a neurologist included a classification according to NCI-CTC and OSNS scales and conduction studies. Genomic DNA was isolated from serum and variants of SCN9A were analyzed by PCR-RFLP. The relation between SCN9A genotype and the development of severe OIN was the primary aim Results: One hundred patients were enrolled between May 2010-November 2011. 56 (56%) females and 44 (44%) males; mean age was 62; mean ECOG was 1; primary tumor were colorectal 81 pts (81%), gastric 10 (10%); 8 (8%) pancreto-biliar and anus 1(1%). Stage were classified in localized 65 (65%) and advanced (35%). The chemotherapy regimen included: 94 (94%) XELOX, 1 (1%) XELOX-Herceptin and 5 (5%) EOX regimen. The mean of cycles were 7 (1-14). Mean OXL dose intensity was 100mg/m2.The mean PFS was 23 months. High expression of SCN9A variants were detected in patients 26/50, 52% arm A and in 5/50, 10% arm B patients, suggesting a possible relationship beetwen the development of OIN and SCN9A genotype (p=0.04). Conclusions: SCN9A polimorphysms may help to identify those patients with a higher risk to develop oxaliplatin induced neuropathy.
Rediscovery of the “ancestralVolvox” species: Morphology and phylogenetic position ofPleodorina sphaerica(Volvocales, Chlorophyceae) from Thailand (2017)

<i>Pleodorina sphaerica</i> Iyengar was considered to be a phylogenetic link between <i>Volvox</i> and the type species <i>Pleodorina californica</i> Shaw because it has small somatic cells distributed from the anterior to posterior poles in 64- or 128-celled vegetative colonies. However, cultural studies and molecular and ultrastructural data are lacking in <i>P. sphaerica</i>, and this species has not been recorded since 1951. Here, we performed light and electron microscopy and molecular phylogeny of <i>P. sphaerica</i> based on newly established culture strains originating from Thailand. Morphological features of the present Thai species agreed well with those of the previous studies of the Indian material of <i>P. sphaerica</i> and with those of the current concept of the advanced members of the Volvocaceae. The present <i>P. sphaerica</i> strains exhibited homothallic sexuality; male and facultative female colonies developed within a single clonal culture. Chloroplast multigene phylogeny demonstrated that <i>P. sphaerica</i> was sister to two other species of <i>Pleodorina</i> (<i>P. californica</i> and <i>Pleodorina japonica</i> Nozaki) without posterior somatic cells, and these three species of <i>Pleodorina</i> formed a robust clade, which was positioned distally in the large monophyletic group including nine taxa of <i>Volvox</i> sect. <i>Merrillosphaera</i> and <i>Volvox</i> (sect. <i>Janetosphaera</i>) <i>aureus</i> Ehrenberg. Based on the present phylogenetic results, evolutionary losses of posterior somatic cells might have occurred in the ancestor of <i>P. californica</i> and <i>P. japonica</i>. Thus, <i>P. sphaerica</i> might represent an ancestral morphology of <i>Pleodorina</i>, rather than of <i>Volvox</i>.
Motion correction for improving the accuracy of dual-energy myocardial perfusion CT imaging (2016)

Coronary Artery Disease (CAD) is the leading cause of death globally [1]. Modern cardiac computed tomography angiography (CCTA) is highly effective at identifying and assessing coronary blockages associated with CAD. The diagnostic value of this anatomical information can be substantially increased in combination with a non-invasive, low-dose, correlative, quantitative measure of blood supply to the myocardium. While CT perfusion has shown promise of providing such indications of ischemia, artifacts due to motion, beam hardening, and other factors confound clinical findings and can limit quantitative accuracy. In this paper, we investigate the impact of applying a novel motion correction algorithm to correct for motion in the myocardium. This motion compensation algorithm (originally designed to correct for the motion of the coronary arteries in order to improve CCTA images) has been shown to provide substantial improvements in both overall image quality and diagnostic accuracy of CCTA. We have adapted this technique for application beyond the coronary arteries and present an assessment of its impact on image quality and quantitative accuracy within the context of dual-energy CT perfusion imaging. We conclude that motion correction is a promising technique that can help foster the routine clinical use of dual-energy CT perfusion. When combined, the anatomical information of CCTA and the hemodynamic information from dual-energy CT perfusion should facilitate better clinical decisions about which patients would benefit from treatments such as stent placement, drug therapy, or surgery and help other patients avoid the risks and costs associated with unnecessary, invasive, diagnostic coronary angiography procedures.
Measurement and Characterization of 60GHz Proximity Channels in Desktop Environments with Electronic Device Chassis (2015)

Measurements of 60GHz proximity channels are performed in desktop environments with a digital camera, a laptop PC, a tablet, a smartphone, and a DVD player. The results are characterized by a statistical channel model. All measured channels are found to be similar to conventional exponential decay profiles that have a relatively large first path due to line-of-sight components. We also show that the power difference between the first path and the delay paths is related to randomization of radio wave polarization by internal reflections in the devices, whereas this is conventionally dependent on only a Rice factor. To express this effect, the conventional model is modified by adding one parameter. Computer simulations confirm that RMS delay spreads of the modeled channels are a good fit to measured channels under most conditions.
Association of Mineralocorticoid Receptor Antagonist Use With All-Cause Mortality and Hospital Readmission in Older Adults With Acute Decompensated Heart Failure (2019)

Use of MRA at discharge from ADHF hospitalization did not appear to be associated with lower mortality but was associated with a lower risk of heart failure readmission. This finding suggests that MRA treatment at discharge may have minimal, if any, clinical advantages.
Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers (2010)

Positive clinicopathological correlations of APE1 expression suggest that APE1 is a potential drug target in ovarian, gastro-oesophageal, and pancreatico-biliary cancers.
Glucose transporter 2 expression is down regulated following P2X7 activation in enterocytes (2012)

With the diabetes epidemic affecting the world population, there is an increasing demand for means to regulate glycemia. Dietary glucose is first absorbed by the intestine before entering the blood stream. Thus, the regulation of glucose absorption by intestinal epithelial cells (IECs) could represent a way to regulate glycemia. Among the molecules involved in glycemia homeostasis, extracellular ATP, a paracrine signaling molecule, was reported to induce insulin secretion from pancreatic β cells by activating P2Y and P2X receptors. In rat's jejunum, P2X7 expression was previously immunolocalized to the apex of villi, where it has been suspected to play a role in apoptosis. However, using an antibody recognizing the receptor extracellular domain and thus most of the P2X7 isoforms, we showed that expression of this receptor is apparent in the top two-thirds of villi. These data suggest a different role for this receptor in IECs. Using the non-cancerous IEC-6 cells and differentiated Caco-2 cells, glucose transport was reduced by more than 30% following P2X7 stimulation. This effect on glucose transport was not due to P2X7-induced cell apoptosis, but rather was the consequence of glucose transporter 2 (Glut2)'s internalization. The signaling pathway leading to P2X7-dependent Glut2 internalization involved the calcium-independent activation of phospholipase Cγ1 (PLCγ1), PKCδ, and PKD1. Although the complete mechanism regulating Glut2 internalization following P2X7 activation is not fully understood, modulation of P2X7 receptor activation could represent an interesting approach to regulate intestinal glucose absorption.
Synthesis of ceratinamine and moloka'iamine: Antifouling agents from the marine sponge Pseudoceratina purpurea (1998)

Syntheses of the title compounds (4 and 5, respectively) are described together with a biogenetic hypothesis that rationalizes the origin of ceratinamine's unique cyanoformamide functionality.
Circulating Microparticles from Crohn’s Disease Patients Cause Endothelial and Vascular Dysfunctions (2013)

We provide evidence that MPs from CD patients significantly alter endothelial and vascular function and therefore, may play a role in CD pathophysiology, at least by contributing to uncontrolled vascular-dependent intestinal damage.
Photoelectrochemical Water Splitting for Hydrogen Production Using Combination of CIGS2 Solar Cell and RuO2 Photocatalyst (2004)

This paper presents the development of photoelectrochemical (PEC) setup using multiple bandgap combination of CuIn1−xGaxS2 (CIGS2) thin-film photovoltaic (PV) cell and ruthenium oxide (RuO2) photocatalyst. FSEC PV Materials Lab has developed a PEC setup consisting of two illuminated CIGS2 cells, a ruthenium oxide (RuO2) anode deposited on titanium sheet for oxygen evolution and a platinum foil cathode for hydrogen evolution. With this combination, a PEC efficiency of 4.29% has been achieved.
The Synthesis of 5-Ethoxycarbonyl-1,2-dimethyl-1,2,3,6-tetrahydropyridine (1970)

The title compound has been synthesised by Dieckmann cyclisation of 2-ethoxycarbonylethyl 1-ethoxycarbonyl-2-propylmethylamine, followed by reduction and dehydration.
Cyberinfrastructure for Open Science at the Montreal Neurological Institute (2017)

Data sharing is becoming more of a requirement as technologies mature and as global research and communications diversify. As a result, researchers are looking for practical solutions, not only to enhance scientific collaborations, but also to acquire larger amounts of data, and to access specialized datasets. In many cases, the realities of data acquisition present a significant burden, therefore gaining access to public datasets allows for more robust analyses and broadly enriched data exploration. To answer this demand, the Montreal Neurological Institute has announced its commitment to Open Science, harnessing the power of making both clinical and research data available to the world (Owens, 2016a,b). As such, the LORIS and CBRAIN (Das et al., 2016) platforms have been tasked with the technical challenges specific to the institutional-level implementation of open data sharing, including: Comprehensive linking of multimodal data (phenotypic, clinical, neuroimaging, biobanking, and genomics, etc.)Secure database encryption, specifically designed for institutional and multi-project data sharing, ensuring subject confidentiality (using multi-tiered identifiers).Querying capabilities with multiple levels of single study and institutional permissions, allowing public data sharing for all consented and de-identified subject data.Configurable pipelines and flags to facilitate acquisition and analysis, as well as access to High Performance Computing clusters for rapid data processing and sharing of software tools.Robust Workflows and Quality Control mechanisms ensuring transparency and consistency in best practices.Long term storage (and web access) of data, reducing loss of institutional data assets.Enhanced web-based visualization of imaging, genomic, and phenotypic data, allowing for real-time viewing and manipulation of data from anywhere in the world.Numerous modules for data filtering, summary statistics, and personalized and configurable dashboards. Implementing the vision of Open Science at the Montreal Neurological Institute will be a concerted undertaking that seeks to facilitate data sharing for the global research community. Our goal is to utilize the years of experience in multi-site collaborative research infrastructure to implement the technical requirements to achieve this level of public data sharing in a practical yet robust manner, in support of accelerating scientific discovery.
Intelligent Traffic Based on Hybrid Control Policy of Connected Autonomous Vehicles in Multiple Unsignalized Intersections (2021)

Over the last decades, several advanced intersection control systems are built to alleviate traffic congestion. Connected Autonomous Vehicles (CAVs) can be more easily developed for cooperative navigation than regular traffic. Due to whole uncertainty in a transportation network, the conventional motion planning for local areas may lead to undesirable consequences in long term. In this context, this paper presents the Micro-Macro Flow Control (MiMaFC) strategy to explore CAVs’ global navigation performance in a traffic network. In prior work, a separate management layer named local supervisor is constructed to control adjacent unsignalized intersections by considering traffic aggregated velocity and vehicle crossing priority. This paper extends the problem to multiple interacting road intersections. Correspondingly, a hybrid control policy is implemented in local areas to solve CAVs conflicts while improving the traffic flow. Further, enhanced intersection navigation protocols are exploited to deal with continued traffic streams. Simulations including a congested traffic network are presented to evaluate the proposed MiMaFC strategy. It is shown in the paper that the mobility in the urban network can be improved by the proposed motion planning framework compared to the non-supervised CAVs system in the same reference conditions.
Successful treatment of a young infant who developed high‐titer inhibitors against VWF‐cleaving protease (ADAMTS‐13): Important discrimination from Upshaw‐Schulman syndrome (2002)

We report herein the case of a 9-month-old female infant with acquired thrombotic thrombocytopenic purpura (TTP), which was initially suspected to be either Upshaw-Schulman syndrome (USS or a congenital TTP) or hemolytic uremic syndrome (HUS) because of onset of clinical signs in infancy and accompanying diarrhea. She received combination therapy of plasma exchange, steroid pulse, and high-dose intravenous immunoglobulin infusion that was initiated before the definitive diagnosis, which resulted in excellent clinical improvement. The retrograde analysis of plasma ADAMTS-13 activity and its inhibitor showed a lack of this enzyme activity and the presence of a high-titer IgG inhibitor (200-320 Bethesda units/mL) to this enzyme activity. From our experience, it was suggested that we should recognize the possibility of the patient with acquired TTP in infancy and the importance of plasma exchange therapy for management of its clinical symptoms.
Probing potential energy surface exploration strategies for complex systems (2014)

The efficiency of minimum-energy configuration searching algorithms is closely linked to the energy landscape structure of complex systems, yet these algorithms often include a number of steps of which the effect is not always clear. Decoupling these steps and their impacts can allow us to better understand both their role and the nature of complex energy landscape. Here, we consider a family of minimum-energy algorithms based, directly or indirectly, on the well-known Bell-Evans-Polanyi (BEP) principle. Comparing trajectories generated with BEP-based algorithms to kinetically correct off-lattice kinetic Monte Carlo schemes allow us to confirm that the BEP principle does not hold for complex systems since forward and reverse energy barriers are completely uncorrelated. As would be expected, following the lowest available energy barrier leads to rapid trapping. This is why BEP-based methods require also a direct handling of visited basins or barriers. Comparing the efficiency of these methods with a thermodynamical handling of low-energy barriers, we show that most of the efficiency of the BEP-like methods lie first and foremost in the basin management rather than in the BEP-like step.
MUSHROOMS AND HEALTH GLOBAL INITIATIVE BULLETIN (2010)

Although gains have been made in premature birth rates among racial and ethnic minority and low socioeconomic status populations, tremendous disparities still exist in both prematurity rates and health outcomes for preterm infants. Parental involvement is known to improve health outcomes for preterm babies. However, a gap in evidence exists around whether parental involvement can help ameliorate the disparities in both short- and long-term out-comes for their preterm children. Families more likely to experience preterm birth are also less likely to have access to paid leave and thus experience significant systemic barriers to involvement, especially when their newborns are hospitalized. This article describes the research gap in this area and explores pathways by which social workers may ameliorate disparities in preterm birth outcomes through practice, policy, and research.
Dynamics and control of multibody/robotic systems with space applications; Proceedings of the ASME Winter Annual Meeting, San Francisco, CA, Dec. 10-15, 1989 (1989)

The present conference on the dynamics and control methods of multibody robotic systems applicable to outer space applications first gives attention to such topics in multibody dynamics and control as the substructure synthesis approach to flexible multibody system control, an elastic finite-element kinematic analysis of a multirigid body, computational methods for high speed vehicles on flexible guideways, and multiarm coordination and control. Attention is then given to such issues in space manipulator dynamics and control methods as the global navigation of a free-flying space robot, dynamic singularities in the control of free-floating space manipulators, experimental results for compact space robot actuator control, and a 17-degree-of-freedom dexterous manipulator.
Realization of a monochip Viterbi decoder in ASIC technology (2002)

An ASIC realization of a Viterbi decoder is presented for the convolutional code of rate 1/2 and constraint length 7 (generator polynomials 133 and 171) and the code derived from it by puncturing to provide a code of rate 3/4, or by reuse of the same polynomials to get codes of rate 1/4 and 1/8. The technology is CMOS 1.5 mu m, and the chip size is 14*14 mm/sup 2/. It contains about 45000 gates plus 3 three-port RAMs. The maximum user data rate of the chip in industrial worst-case conditions at 17 Mbit/s. The circuit is comprised of a coder and a decoder whose characteristics are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Audio watermarking: features, applications and algorithms (2000)

This paper considers the desired properties and possible applications of audio watermarking algorithms. Special attention is given to statistical methods working in the Fourier domain. It presents a solution to robust watermarking of audio data and reflects the security properties of the technique. Experimental results show good robustness of the approach against MP3 compression and other common signal processing manipulations. Enhancements to the presented methods are discussed.