gebhart/patrepeval huggingface dataset:
Semiconstrained elbow replacement for distal humeral nonunion (1995)

We have reviewed 36 of 39 consecutive patients with an average age of 68 years who had semiconstrained elbow replacement for distal humeral nonunion at an average follow-up of 50.4 months (24 to 127). Of these, 31 (86%) had satisfactory results, three (8%) had fair, and two (6%) had poor results; 32 patients (88%) had moderate or severe pain before and 91% had no or only mild discomfort after the procedure. Motion had improved from a mean arc of 29 degrees to 103 degrees before operation to 16 degrees to 127 degrees after surgery. All five flail extremities were stable at last assessment. There were seven complications (18%): two patients had deep infection, two had particulate synovitis, two had ulnar neuropathy and one had worn polyethylene bushes. Five of these seven, excluding the two with transient nueropathy, required reoperation (13%). Joint replacement arthroplasty can be a safe and reliable treatment for this difficult clinical condition, seen most commonly in elderly patients. This is a significant advance, since repeated osteosynthesis has been shown to be ineffective in most patients.
Thermal Well Completions and Operation (1967)

Thermal recovery wells in unconsolidated sands generally require metal liners to withstand external loads. During combustion operations, burning inside or immediately outside the pipe will cause failure. Injection and producing well-completion methods and operational techniques to give years of life during combustion operations despite potentially high temperatures and hot corrosive conditions are discussed. For steaming of well-completion, methods and operations are discussed which will minimize failures caused by stresses and elongation due to high temperature and pressure. High temperature cements and cementing practices, and production equipment requirements are also reviewed.
Influence of genotype and nutrition on survival and metabolism of starving yeast (2008)

Starvation of yeast cultures limited by auxotrophic requirements results in glucose wasting and failure to achieve prompt cell-cycle arrest when compared with starvation for basic natural nutrients like phosphate or sulfate. We measured the survival of yeast auxotrophs upon starvation for different nutrients and found substantial differences: When deprived of leucine or uracil, viability declined exponentially with a half-life of <2 days, whereas when the same strains were deprived of phosphate or sulfate, the half-life was approximately 10 days. The survival rates of nongrowing auxotrophs deprived of uracil or leucine depended on the carbon source available during starvation, but were independent of the carbon source during prior growth. We performed an enrichment procedure for mutants that suppress lethality during auxotrophy starvation. We repeatedly found loss-of-function mutations in a number of functionally related genes. Mutations in PPM1, which methylates protein phosphatase 2A, and target of rapamycin (TOR1) were characterized further. Deletion of PPM1 almost completely suppressed the rapid lethality and substantially suppressed glucose wasting during starvation for leucine or uracil. Suppression by a deletion of TOR1 was less complete. We suggest that, similar to the Warburg effect observed in tumor cells, starving yeast auxotrophs wastes glucose as a consequence of the failure of conserved growth control pathways. Furthermore, we suggest that our results on condition-dependent chronological lifespan have important implications for the interpretation and design of studies on chronological aging.
In-Line Leukocyte Filtration During Bypass (1996)

Leukocyte mediated pulmonary injury may delay recovery after cardiac surgery, and leukocyte depletion during bypass has been suggested. Two groups of patients were randomly, prospectively assigned from 50 sequential patients to undergo open heart surgery using cardiopulmonary bypass, either with (n = 25) or without (n = 25) leukocyte filters. The two groups were not significantly different regarding age, gender, race, pre-operative ejection fraction, pump time, or cross-clamp time. Post operative arterial blood gases (pO2: 173 ± 66 vs 192 ± 107; pCO2: 30.2 ± 8.2 vs 30.8 ± 8.0), pulmonary vascular resistance (PVR 105 ± 45 vs 112 ± 50 dyne cm-5), time on ventilator (17.8 ± 6.4 vs 19.7 ± 8.6 hr), and length of hospital stay (7.65 ± 4.57 vs 8.52 ± 5.87 days) were not different between groups (mean $$ SD, with vs without filters, respectively). Arterial oxygenation was somewhat poorer, and PVR was somewhat lower in the leukocyte filtered group. However, these trends did not produce significant decreases in total ventilator time or length of hospital stay. In-line filtration did remove leukocytes, but did not reduce circulating leukocyte count. In effect, leukocyte filtration produced an effective leukocyte concentration at the filter site. These data do not support routine incorporation of in-line leukocyte filtration during bypass.
File Synchronization with Vector Time Pairs (2005)

Vector time pairs are a new method for tracking synchronization metadata. A vector time pair consists of two vector times: one tracking file modification history and one tracking file synchronization history. Because the vector times are maintained separately and used for different purposes, different algorithms and optimizations can be applied to each. As a result, vector time pairs impose no restriction on synchronization patterns, never falsely detect conflicts, require no space to store deletion notices, require network bandwidth proportional only to the number of files changed, and support partial synchronizations. No other current synchronization method has all these properties. Results from an implementation of vector time pairs in a new user-level file synchronizer called Tra confirm the benefits of vector time pairs.
Steels: microstructure and properties (1996)

Iron and its interstitial solid solutions * The strengthening of iron and its alloys * The iron-carbon equilibrium diagram and plain carbon steels * The effects of alloying elements in iron-carbon alloys * Formation of martensite * The bainite reaction * Acicular ferrite * The heat treatment of steels - hardenability * The tempering of martensite * Commercial Steels: New material to include Nanostructured Steels, Steels for the Energy and Automobile Industries * The embrittlement and fracture of steels * Stainless steel * Weld microstructures * Modelling of microstructure and properties *
Computing Bayes-Nash Equilibria in Combinatorial Auctions with Continuous Value and Action Spaces (2017)

Combinatorial auctions (CAs) are widely used in practice, which is why understanding their incentive properties is an important problem. However, finding Bayes-Nash equilibria (BNEs) of CAs analytically is tedious, and prior algorithmic work has only considered limited solution concepts (e.g. restricted action spaces). In this paper, we present a fast, general algorithm for computing symmetric pure ε-BNEs in CAs with continuous values and actions. In contrast to prior work, we separate the search phase (for finding the BNE) from the verification step (for estimating the ε), and always consider the full (continuous) action space in the best response computation. We evaluate our method in the well-studied LLG domain, against a benchmark of 16 CAs for which analytical BNEs are known. In all cases, our algorithm converges quickly, matching the known results with high precision. Furthermore, for CAs with quasi-linear utility functions and independently distributed valuations, we derive a theoretical bound on ε. Finally, we introduce the new Multi-Minded LLLLGG domain with eight goods and six bidders, and apply our algorithm to finding an equilibrium in this domain. Our algorithm is the first to find an accurate BNE in a CA of this size.
Synthetic lethality screens of vichem compounds in P53 mutant syngenic cell line models (2008)

Introduction: Kinase inhibitors are promising new class anticancer agents in gastrointestinal malignancies.
Detection of major genes and determination of genotypes application to discrete variables (1990)

"Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access "
Transient Ion Drift Measurements of Polycrystalline CdTe PV Devices (2006)

The well known transient ion drift (TID) method is used to quantify the density of mobile Cu interstitial ions in polycrystalline CdTe PV cells. Average Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> ion densities in optimally processed cells are 20% of the background ionized acceptor doping level. A preliminary estimate of the diffusion coefficient for Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> ions in the polycrystalline CdTe absorber is D(Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> )=1.3E-6 [cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /sec] times exp[-0.29 eV/(KB*T)] in the temperature range of 25degC to 55degC from TID measurements. Aspects of the TID method as pertains to practical thin film polycrystalline devices are discussed
Targeting tumor vulnerabilities associated with loss of heterozygosity (2020)

We show that N-acetyltransferase 2 (<i>NAT2</i>) loss of heterozygosity can be targeted in >4% of colorectal cancers with the use of a small molecule. We identify and describe the effect of a compound that impairs the growth of colorectal tumors with slow NAT2 activity by half when compared to wild-type.
Identification of critical genes associated with human osteosarcoma metastasis based on integrated gene expression profiling (2019)

Osteosarcoma is the most common type of malignant bone cancer, which often affects teenagers and young adults. The present study aimed to screen for critical genes and microRNAs (miRNAs/miRs) involved in osteosarcoma. A total of four microarray datasets (accession numbers GSE32981, GSE21257, GSE14827 and GSE14359) were downloaded from the Gene Expression Omnibus database. Following data preprocessing, module analysis was performed to identify the stable modules using the weighted gene co‑expression network analysis (WGCNA) package. The differentially expressed genes (DEGs) between metastatic samples and non‑metastatic samples were screened, followed by gene co‑expression network construction, and Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway analyses. Subsequently, prognosis‑associated genes were screened and a miRNA‑target gene regulatory network was constructed. Finally, the data for critical genes were validated. WGCNA analysis identified six modules; blue and yellow modules were significantly positively associated with osteosarcoma metastasis. A total of 1,613 DEGs were screened between primary tissue samples and metastatic samples. Following comparison of the genes in the two (blue and yellow) modules, a total of 166 DEGs were identified (metastatic samples vs. non‑metastatic samples). Functional enrichment analysis demonstrated that these DEGs were mainly involved in 'defense response', 'p53 signaling pathway' and 'lysosome'. By utilizing the clinical information in GSE21257, 10 critical genes associated with osteosarcoma prognosis were obtained, including CTP synthase 2 (CTPS2), tumor protein p53 inducible protein 3 (TP53I3) and solute carrier family 1 member 1 (SLC1A1). In addition, hsa‑miR‑422a and hsa‑miR‑194 were highlighted in the miRNA‑target gene network. Finally, matrix metallopeptidase 3 (MMP3) and vascular endothelial growth factor B (VEGFB) were predicted as critical genes in osteosarcoma metastasis. CTPS2, TP53I3 and SLC1A1 may serve major roles in osteosarcoma development, and hsa‑miR‑422a, hsa‑miR‑194, MMP3 and VEGFB may be associated with osteosarcoma metastasis.
A weighted least‐squares method for nuclear magnetic resonance velocity imaging (1993)

The phase method for velocity measurements in NMR imaging with more than two velocity encoding steps is discussed. The weighted least-squares method takes into account the variation in the accuracy of phase calculations at a voxel with the size of the velocity encoding gradients. We choose the weights so that the method is equivalent to the method of maximum-likelihood for high signal-to-noise ratios. We propose a method of implementation to minimize the problem of phase wrapping. We also discuss the number of velocity encoding steps, the choice of step size, and signal averaging, to improve the reproducibility of velocity measurements. Standard deviation images for the velocity have been calculated and used to reduce velocity noise by thresholding the velocity image.
Secretion properties, clearance, and therapy in airway disease (2014)

Chronic airway diseases like cystic fibrosis, chronic bronchitis, asthma, diffuse panbronchiolitis, and bronchiectasis are all associated with chronic inflammation. The airway mucosa responds to infection and inflammation in part by surface mucous (goblet) cell and submucosal gland hyperplasia and hypertrophy with mucus hypersecretion. Products of inflammation including neutrophil derived DNA and filamentous actin, effete cells, bacteria, and cell debris all contribute to mucus purulence and, when this is expectorated it is called sputum. Mucus is usually cleared by ciliary movement, and sputum is cleared by cough. These airway diseases each are associated with the production of mucus and sputum with characteristic composition, polymer structure, and biophysical properties. These properties change with the progress of the disease making it possible to use sputum analysis to identify the potential cause and severity of airway diseases. This information has also been important for the development of effective mucoactive therapy to promote airway hygiene.
Modified Nucleosides in Biochemistry, Biotechnology and Medicine (2009)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewModified Nucleosides in Biochemistry, Biotechnology and MedicineChristine S. ChowView Author Information Wayne State UniversityCite this: J. Am. Chem. Soc. 2009, 131, 11, 4169–4170Publication Date (Web):March 4, 2009Publication History Published online4 March 2009Published inissue 25 March 2009https://pubs.acs.org/doi/10.1021/ja901280dhttps://doi.org/10.1021/ja901280dbook-reviewACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views1280Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biochemistry,Biotechnology,Genetics,Medicinal chemistry,Nucleic acids Get e-Alerts
Preparation, stereochemistry, and nuclear magnetic resonance spectroscopy of 4-hydroxy(acetoxy)bicyclo[5.1.0]octanes. Synthesis of (-)- and (.+-.)-8,8-dimethylbicyclo[5.1.0]oct-2-en-4-one (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation, stereochemistry, and nuclear magnetic resonance spectroscopy of 4-hydroxy(acetoxy)bicyclo[5.1.0]octanes. Synthesis of (-)- and (.+-.)-8,8-dimethylbicyclo[5.1.0]oct-2-en-4-oneMichael D. Taylor, Gevork Minaskanian, Kevin N. Winzenberg, Patricia Santone, and Amos B. Smith IIICite this: J. Org. Chem. 1982, 47, 20, 3960–3964Publication Date (Print):September 1, 1982Publication History Published online1 May 2002Published inissue 1 September 1982https://doi.org/10.1021/jo00141a029RIGHTS & PERMISSIONSArticle Views813Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Bandwidth Re-Distribution Techniques for Extended EPON Based Multi-Wavelength Networks (2007)

The broadband photonics project (BBP) under the Freehand consortium of projects looks into the design of an extended access network. The network is a photonic network which can be dynamically reconfigured to distribute bandwidth in an optimised manner. This paper presents linear programming based formulations to calculate implementation of bandwidth redistribution in the network.
Abrupt alcohol withdrawal: another cause of ketoacidosis often forgotten (2008)

A 54-year-old woman was admitted to our emergency department for acute confusion. She had only a history of chronic alcohol abuse with an abrupt withdrawal. The initial diagnosis was delirium tremens. Biological findings, however, showed a severe degree of metabolic acidosis (plasma pH 7.07, bicarbonate 9.6 mmol/l) with an increased anion gap (39.6 mmol/l). Serum glucose was normal and ketonuria was present. Ketoacidosis was also suspected and treated by fluid infusion and delivery of glucose with a favorable outcome. Differential ketoacidosis is discussed in the emergency room.
Various Extraction Methods for Obtaining Stilbenes from Grape Cane of Vitis vinifera L. (2015)

Grape cane, leaves and grape marc are waste products from viticulture, which can be used to obtain secondary stilbene derivatives with high antioxidant value. The presented work compares several extraction methods: maceration at laboratory temperature, extraction at elevated temperature, fluidized-bed extraction, Soxhlet extraction, microwave-assisted extraction, and accelerated solvent extraction. To obtain trans-resveratrol, trans-ε-viniferin and r2-viniferin from grape cane of the V. vinifera variety Cabernet Moravia, various conditions were studied: different solvents, using powdered versus cut cane material, different extraction times, and one-step or multiple extractions. The largest concentrations found were 6030 ± 680 µg/g dry weight (d.w.) for trans-resveratrol, 2260 ± 90 µg/g d.w. for trans-ε-viniferin, and 510 ± 40 µg/g d.w. for r2-viniferin. The highest amounts of stilbenes (8500 ± 1100 µg/g d.w.) were obtained using accelerated solvent extraction in methanol.
Inhibitory effects of pentamidine analogues on protein biosynthesis in vitro. (2000)

Pentamidine despite its rather high toxicity, is currently in clinical use. For development of new drugs of this type it is important to know the mechanism of their action. Two new amidines (I and II) and 4',6-diamidino-2-phenylindole (DAPI) were found in preliminary experiments to inhibit protein synthesis in vitro in the cell-free rat liver system. The three compounds differed in the precise mode of action. The inhibitory effect of I on the activity of the eukaryotic elongation factor eEF-2 and ribosomes seems to suggest that the binding site of eEF-2 on the ribosome was blocked by this compound. eEF-2 has been identified as the primary target of II and eEF-1 as the primary target of DAPI in the system studied.
Supplementary Figure 1 from Phase II window study of olaparib alone or with cisplatin or durvalumab in operable Head and Neck Cancer (2023)

&lt;p&gt;Supplementary Figure 1. Differentially expressed genes (Left) and gene signatures (Right) Cisplatin-Olaparib (A, B), Olaparib (C,D) and Durvalumab-Olaparib (E, F) arms in pre- and post-treatment samples. The significance (p-value, P and adjusted p-value, Padj) is represented relative to Fold Change (FC) in the x-axis.&lt;/p&gt;
Development of a Biocompatible Solid Phase Microextraction Thin Film Coating for the Sampling and Enrichment of Peptides (2020)

While currently available methods for peptide sample preparation are mostly suitable for <i>ex situ</i> analysis <i>via</i> exhaustive extraction techniques, these techniques do not allow for <i>in situ</i> extraction of peptides from biological samples, such as blood or plasma collected from patients for routine clinical applications. Biocompatible solid phase microextraction (Bio-SPME) has shown great potential in metabolomics for <i>in situ</i> extraction of metabolites including labile compounds from biological matrices in a biocompatible and non-exhaustive fashion, thus facilitating even <i>in vivo</i> sampling. However, the amounts of peptides extracted by such Bio-SPME chemical biopsy tools are deemed too low for quantification when porous polyacrylonitrile (PAN)-based biocompatible thin film sorbent coatings are used, since such materials have been commonly applied as means to restrict access of high molecular weight compounds such as proteins. Aiming to improve peptide extraction by the SPME sorbent while still preventing protein adsorption, thin films with nanoscale irregularities and mesopores were prepared by inclusion of the porogen lithium perchlorate in the slurries of the coatings. The novel thin film coating method significantly improved extraction of a range of angiotensins known to possess important roles in blood pressure regulation and electrolyte balance. Model low abundance peptides covering a wide range of hydrophobicities were successfully extracted from physiological buffers and human plasma using the increased porosity coating, while the SPME protocol on the tryptic digestion of a protein supported that enzymes were excluded during peptide extraction. Surface rheological analysis, which displayed mesopores on the C18/PAN coatings, confirmed that the porosity of the coating facilitated the mass transport of peptides through the PAN layer, thus enabling extraction of high amounts of peptides by the new C18/PAN coating.