gebhart/patrepeval huggingface dataset:
Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein Dishevelled (2009)

A new application: The nonsteroidal anti-inflammatory drug sulindac interacts directly and specifically with the PDZ domain of the protein Dishevelled (Dvl), which is a key intracellular component of the Wnt signaling pathways. Sulindac binds to the conventional peptide-binding pocket of the domain (see picture), and may exert a cancer chemoprotective effect by blocking it, thereby inhibiting canonical Wnt signaling. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Crystal structure and physical properties of new boride Ca1+ϵCo4B4 (2009)

We report the crystal structures and physical properties of a novel boride Ca1+Co4B4. This is a Gd1+Fe4B4-type compound, composed of tetrahedral chains of CoB and infinite atomic chains of Ca, with independent translation periods cCa and cCo. This is the first boride of this structural type that has a divalent metal at the rare earth site. The very low electrical resistivity showing linear decrease with decreasing temperature indicated a highly metallic nature of Ca1+Co4B4. The very small magnetization suggested that Ca1+Co4B4 is paramagnetic. First-principles calculations supported this paramagnetism, and revealed the nature of chemical bonding and electric conduction in this compound.
Author response: Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss (2015)

Cell type-specific transcriptomics in energy homeostasis neurons has identified hundreds of genes and multiple signaling pathways that are regulated by weight loss in mice, as well as several previously unexamined genes that can regulate appetite and body weight.
Collision-induced dissociation dynamics in O2++Ne(Ar) collisions: The role of electronic excitation (2000)

Integral collision-induced dissociation (CID) cross sections at center-of-mass (CM) energies ranging from threshold to 22 eV and product ion recoil velocity distributions are presented for O2++Ne(Ar) collisions. The O2+ ions are produced in an electron impact ion source and thus have ∼0.5 eV of vibrational energy. The O2++Ne CID cross sections are observed at energies below the 0 K thermodynamic threshold of 6.66 eV, implying the possibility of significant vibrational effects. A second CID threshold is apparent at 9±1 eV. This is close to the charge-transfer (CT) threshold energy. No CT products are observed. The O2++Ar CID cross section rises rapidly above a relative translational energy onset of 7.5±0.2 eV and reaches a maximum value of ∼0.8 Å2 at 14 eV (CM). A CT onset of 6.0±0.2 eV is observed which is close to the thermodynamic threshold for CID. The energy dependence of the CT cross section is very similar to the CID cross section except for a small step at energies where CID becomes efficient. The CID recoil velocity distributions near threshold are centered at the CM velocity and shift to forward preference at higher energies. The O2++Ar CT recoil velocities are forward scattered near threshold and become centered with respect to the CM velocity at energies where competition with CID is apparent.
ChemInform Abstract: First Synthesis of 4a‐Carba‐β‐D‐galactofuranose (I). (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Comparative Study of the Effects Induced by Different Laccase-Based Systems on Sisal Cellulose Fibers (2012)

This paper reports a comparative study of the effects induced on sisal pulp fibers by three different laccase-based systems, namely, laccase–sinapyl aldehyde, laccase–ferulic acid, and laccase–TEMPO systems, applied to perform biobleaching, biografting, and cellulose oxidation, respectively. (The abbreviations SLD, FRC, and TEMPO are used to represent sinapyl aldehyde, ferulic acid, and the 2,2,6,6-tetramethylpiperidine-1-oxyl free radical.) A novel aspect of this study was the use of thermogravimetric analysis (TGA) to monitor surface changes in cellulosic microfibrils during the enzyme treatments and gain a greater understanding of the mechanisms of action of the laccase-based systems. The different modes of action of the studied laccase-based systems reflected in the different degradation profiles of pulps after treatment. TGA showed laccase to modify the thermal degradation path of the initial pulp, increasing the proportion of cellulose degrading at low temperature. The addition of SLD resulted in virtually no change of the thermal degradation path of the initial pulp, indicating that the laccase–SLD system basically exerted its action on the lignin component of fibers. In contrast to SLD, FRC was found to significantly increase the amount of the paracrystalline fraction of cellulose, probably as a consequence of its incorporation into fibers. The presence of TEMPO, especially under those conditions boosting the oxidative functionalization, was found to cause an intense degradation of cellulose and the formation of a substantial amount of amorphous cellulose degrading at low temperature. A novel aspect of the laccase–TEMPO system was identified in this work: its ability to reduce the hexenuronic acids (HexA) content content of pulp, under specific reaction conditions.
Contaminant intrusion in water distribution networks: review and proposal of an integrated model for decision making (2015)

Contaminant intrusion in a distribution network (DN) refers to the entry of harmful chemicals and pathogens in the presence of three conditions: (i) the availability of a contaminant source near water mains; (ii) a pathway: leakage or breakage; and (iii) a driving force: low or negative pressure in the water main. The occurrence of contamination in a DN can take place frequently as there is no specific treatment at this stage except secondary disinfection. Contaminant intrusion requires as much attention as source water protection or treatment plants, particularly given that at this point, water is near the final stage prior to human consumption. Failure to detect and treat at this time could have potential negative impacts on consumers’ health. Following the September 11, 2001 attack, strict regulations are now enforced by the municipalities to monitor water quality within DNs. This review article focuses on various aspects of contaminant intrusion in DNs based on more than 90 journal articles, peer-reviewed conference proceedings, and research reports. Here we present details on the conditions of contaminant intrusion, water quality regulations, sampling, protection and mitigation strategies, and various modelling approaches for decision making. Based on this review, we propose an integrated model that will help guide effective decision making for contaminant detection and mitigation.
Synthesis Route Impact on BiVO4 Nanoparticles and their Visible Light Photocatalytic Activity Under Green LED Irradiation (2019)

The present study demonstrates the BiVO₄ nanoparticles synthesized by co-precipitation (CPM), hydrothermal (HTM) and solution combustion method (SCM) and their visible light photocatalytic activity under irradiation of green light emitting diodes. The synthesized catalysts were characterized by Powder X-ray Diffraction, UV-vis Diffuse reflectance spectroscopy, BET Surface area analysis, Fourier Transform Infrared spectroscopy and Scanning electron microscopy. Result demonstrated that the photocatalytic activity of BiVO₄ catalyst synthesized by solution combustion method has 4.7, 1.9 and 6.7 times higher photocatalytic activity under irradiation of green light emitting diodes as compared to ultraviolet, blue and red light emitting diodes respectively. It has also been found that the photocatalytic activity of the synthesized BiVO₄ by SCM is 6.5 times more as compared to commercial TiO2 under green light emitting diodes irradiation. Furthermore, the room temperature fluorescence and quenching analysis was carried out for the determination of hydroxyl radical generation and understanding photocatalytic activity of the catalyst under green light emitting diodes irradiation. Additionally, the effect of operational parameters under irradiation of green light emitting diodes was studied to optimize catalyst amount, pH, initial dye concentration and amount of H2O2. Recyclability study concern about solution combustion synthesized BiVO₄ catalyst has also been done up to 5 cycles in presence of green light emitting diodes irradiation.
Oxocarboxylic Acids (2000)

Abstract The article contains sections titled: 1. Introduction 2. Pyruvic Acid 3. Acetoacetic Acid and Derivatives 3.1. Properties 3.2. Production 3.3. Uses and Economic Aspects 3.4. Toxicology and Environmental Protection 4. Levulinic Acid 5. Acetonedicarboxylic Acid 6. Other Oxocarboxylic Acids
Anterior sacral pseudomeningocele following minimal trauma (2013)

Sacral fractures are rare and seldom result in formation of a sacral pseudomeningocele. Treatment of these pseudomeningoceles usually consists of conservative management with flat bedrest or open operative management. The authors describe the case of a 55-year-old woman with an anterior sacral pseudomeningocele that was successfully treated using a lumbar drain for temporary continuous CSF drainage. The patient first presented to an outside institution several days after sacral trauma from an ice skating fall. Initial symptoms included throbbing headaches relieved by lying flat. Head and cervical spine CT demonstrated no abnormality. As symptoms worsened, she presented to another institution where MRI of the lumbar spine indicated sacral fracture with pseudomeningocele. The patient subsequently transferred to the authors' facility, where symptoms included headaches and occasional mild sacral pain. Given her headaches and the authors' concern for CSF leak, another head CT scan was performed. This revealed no subdural hematoma or other abnormality. A subsequent CT myelogram revealed an anterior sacral pseudomeningocele at S3-4 with an anterior irregular linear filling defect, likely representing torn dura. Treatment included placement of a lumbar drain (10 ml/hr) and flat bedrest. Resolution of the CSF leak occurred on postprocedure Day 9. At the 4-week follow-up visit, the patient had no clinical symptoms of CSF leak and no neurological complaints. To our knowledge, this is the first description of temporary continuous CSF drainage used to treat a posttraumatic sacral pseudomeningocele. This technique may reduce the need for potentially complicated surgical repair of sacral fractures associated with CSF leak in select patients.
Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64 (1997)

Mutations selected in reoviruses isolated from persistently infected cultures (PI viruses) affect viral entry into cells. Unlike wild-type (wt) viruses, PI viruses can grow in the presence of ammonium chloride, a weak base that blocks acid-dependent proteolysis of viral outer-capsid proteins in cellular endosomes during viral entry. In this study, we show that E64, an inhibitor of cysteine proteases such as those present in the endocytic compartment, blocks growth of wt reovirus by inhibiting viral disassembly. To determine whether PI viruses can grow in the presence of an inhibitor of endocytic proteases, we compared yields of wt and PI viruses in cells treated with E64. Prototype PI viruses L/C, PI 2A1, and PI 3-1 produced substantially greater yields than wt viruses type 1 Lang (T1L) and type 3 Dearing (T3D) in E64-treated cells. To identify viral genes that segregate with growth of PI viruses in the presence of E64, we tested reassortant viruses isolated from independent crosses of T1L and each of the prototype PI viruses for growth in cells treated with E64. Growth of reassortant viruses in the presence of E64 segregated exclusively with the S4 gene, which encodes viral outer-capsid protein sigma3. These results suggest that mutations in sigma3 protein selected during persistent infection alter its susceptibility to cleavage during viral disassembly. To determine the temporal relationship of acid-dependent and protease-dependent steps in reovirus disassembly, cells were infected with wt strain T1L or T3D, and medium containing either ammonium chloride or E64d, a membrane-permeable form of E64, was added at various times after adsorption. Susceptibility to inhibition by both ammonium chloride and E64 was abolished when either inhibitor was added at times greater than 60 min after adsorption. These findings indicate that acid-dependent and protease-dependent disassembly events occur with similar kinetics early in reovirus replication, which suggests that these events take place within the same compartment of the endocytic pathway.
Separation of Peptides on HALO 2‐Micron Particles (2016)

Reversed-phase high-performance liquid chromatography (RP-HPLC) is of fundamental importance to the isolation and separation of peptides, proteins, and other biomolecules. Hence, there is a continuing high demand for the development of RP-HPLC stationary-phase materials with enhanced separation efficiency. HALO packing materials began the revolution in "core-shell" technology with the advantages of faster separations, higher resolution and peak capacity, high temperature stability, and rugged reliable performance compared to traditional HPLC and UHPLC. These materials are characterized by a solid core surrounded by a thin layer of porous material, and represent a technology for the future with continuing refinements. Such refinements are aided via the use of designed synthetic peptide standards during stationary-phase development. Concomitantly, such standards also enable the researcher to monitor RP-HPLC column performance and develop optimized separation protocols for peptides from a wide array of sources. © 2016 by John Wiley & Sons, Inc.
Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy (2010)

Diabetic neuropathy (DN) is a debilitating disorder occurring in most diabetic patients without a viable treatment yet. The present work examined the protective effect of (25)Mg-PMC(16) nanoparticle (porphyrin adducts of cyclohexil fullerene-C60) in a rat model of streptozotocin (STZ)-induced DN. (25)Mg-PMC(16) (0.5 lethal dose(50) [LD(50)]) was administered intravenously in two consecutive days before intraperitoneal injection of STZ (45 mg/kg). (24)Mg-PMC(16) and MgCl(2) were used as controls. Blood 2,3-diphosphoglycerate (2,3-DPG), oxidative stress biomarkers, adenosine triphosphate (ATP) level in dorsal root ganglion (DRG) neurons were determined as biomarkers of DN. Results indicated that 2,3-DPG and ATP decreased whereas oxidative stress increased by induction of DN which all were improved in (25)Mg-PMC(16)-treated animals. No significant changes were observed by administration of (24)Mg-PMC(16) or MgCl(2) in DN rats. It is concluded that in DN, oxidative stress initiates injuries to DRG neurons that finally results in death of neurons whereas administration of (25)Mg-PMC(16) by release of Mg and increasing ATP acts protectively.
Killer immunoglobulin-like receptor and cancer (2022)

Our results do not provide evidence of an association between pediatric cancer disease with genotypes and groups of genes KIRs. The k2DS1_C2 genotype could predispose to susceptibility to malignant processes in children.
Circulating fluidized bed combustion of a high‐sulphur eastern canadian coal (1991)

Abstract Combustion tests were carried out with Minto coal in combination with three different limestones in the University of British Columbia (UBC) pilot scale (152 mm square x 7.3 m tall) circulating fluidized bed combustion (CFBC) unit. Operating conditions were chosen to be typical of those employed in large‐scale CFBC power boilers. Recycling of fine particles captured by the secondary cyclone was found to be of considerable importance in increasing sulphur capture, enhancing combustion efficiency and reducing the amount of calcium sulphide in the solids residues. NO x emissions increased as the Ca:S ratio increased. Local gas concentrations inside the reactor were strongly influenced by the core‐annulus solids distribution patterns which characterize circulating fluidized beds.
Applications and Challenges of Wearable Visual Lifeloggers (2017)

Advances in the manufacturing of miniaturized low-power embedded systems are paving the way for ultra-lightweight wearable cameras that can visually log the minute details of people's daily lives. This survey highlights the possible applications of wearable cameras, from industrial to personal, and outlines the main challenges in realizing their full potential.
Colon-Specific Deletion of Epithelial Sodium Channel Causes Sodium Loss and Aldosterone Resistance (2014)

Aldosterone promotes electrogenic sodium reabsorption through the amiloride-sensitive epithelial sodium channel (ENaC). Here, we investigated the importance of ENaC and its positive regulator channel-activating protease 1 (CAP1/Prss8) in colon. Mice lacking the αENaC subunit in colonic superficial cells (Scnn1a(KO)) were viable, without fetal or perinatal lethality. Control mice fed a regular or low-salt diet had a significantly higher amiloride-sensitive rectal potential difference (∆PDamil) than control mice fed a high-salt diet. In Scnn1a(KO) mice, however, this salt restriction-induced increase in ∆PDamil did not occur, and the circadian rhythm of ∆PDamil was blunted. Plasma and urinary sodium and potassium did not change with regular or high-salt diets or potassium loading in control or Scnn1a(KO) mice. However, Scnn1a(KO) mice fed a low-salt diet lost significant amounts of sodium in their feces and exhibited high plasma aldosterone and increased urinary sodium retention. Mice lacking the CAP1/Prss8 in colonic superficial cells (Prss8(KO)) were viable, without fetal or perinatal lethality. Compared with controls, Prss8(KO) mice fed regular or low-salt diets exhibited significantly reduced ∆PDamil in the afternoon, but the circadian rhythm was maintained. Prss8(KO) mice fed a low-salt diet also exhibited sodium loss through feces and higher plasma aldosterone levels. Thus, we identified CAP1/Prss8 as an in vivo regulator of ENaC in colon. We conclude that, under salt restriction, activation of the renin-angiotensin-aldosterone system in the kidney compensated for the absence of ENaC in colonic surface epithelium, leading to colon-specific pseudohypoaldosteronism type 1 with mineralocorticoid resistance without evidence of impaired potassium balance.
Ultraviolet resonance Raman spectroscopy of the nucleotides with 266-, 240-, 218-, and 200-nm pulsed laser excitation (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUltraviolet resonance Raman spectroscopy of the nucleotides with 266-, 240-, 218-, and 200-nm pulsed laser excitationStephen P. A. Fodor, Richard P. Rava, Thomas R. Hays, and Thomas G. SpiroCite this: J. Am. Chem. Soc. 1985, 107, 6, 1520–1529Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/ja00292a012https://doi.org/10.1021/ja00292a012research-articleACS PublicationsRequest reuse permissionsArticle Views1099Altmetric-Citations244LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PRELI (protein of relevant evolutionary and lymphoid interest) is located within an evolutionarily conserved gene cluster on chromosome 5q34-q35 and encodes a novel mitochondrial protein (2004)

The characterization of mitochondrial proteins is important for the understanding of both normal cellular function and mitochondrial disease. In the present study we identify a novel mitochondrial protein, PRELI (protein of relevant evolutionary and lymphoid interest), that is encoded within the evolutionarily conserved MAD3/PRELI/RAB24 gene cluster located at chromosome 5q34-q35. Mouse Preli is expressed at high levels in all settings analysed; it is co-expressed with Rab24 from a strong bi-directional promoter, and is regulated independently from the S-phase-specific Mad3 gene located at its 3' end. PRELI contains a stand-alone 170 amino acid PRELI/MSF1p' motif at its N-terminus. This domain is found in a variety of proteins from diverse eukaryotes including yeast, Drosophila and mammals, but its function is unknown, and the subcellular location of higher eukaryotic PRELI/MSF1P' proteins has not been determined previously. We show here that PRELI is located in the mitochondria, and by using green-fluorescent-protein fusion proteins we identify a mitochondrial targeting signal at its N-terminus.
Characterization of Growth Retardated Preimplantation Embryos Obtained from Donor Oocytes. (2012)

Different problems of infertility raise more and more the involvement of donoroocytes usage for the in vitro fertilization. Despite the abundance of successful procedure there is also enough high percentage of invalid for implantation embryos obtained from donoroocytes. Thus, aim of work was detection of differences between different growth factors, their receptors, stem cell surface markers and metabolic enzymes in embryos of donoroocytes after in vitro fertilization. All together 19 embryos obtained from donoroocytes aged of 3 days were growth retardated and donated by their recipient mothers (I group). The comparison group consisted of different n 3 days old 63 embryos also retardated in growth and donated after IVF and ICSI by their mothers (II group). Immunohistochemistry was used for detection of lactate dehydrogenase (LD), hexokinase (Hex), basicFGF, FGFR1, IGF, IGF1R, TGFalfa, and Oct3/4. Donoroocyte embryos showed abundant expression of IGF, IGF1R and LD in comparison to female own oocyte embryos where only few cells were factor positive. TGFalfa expression didn't show any difference between the groups. Only few cells of donoroocyte embryos were Oct3/4 positive while this factor was notably more in female own embryos. Donoroocyte embryos were negative for Hex and basicFGF while female own embryos demonstrated various expressions of these factors. Moderate number of cells expressed FGF1R in donoroocyte embryos, but II group embryos possessed variable expression for this factor. Conclusions. Despite the growth retardation 3 days old donoroocyte embryos show high LD expression and absence of Hex that respond to the correct metabolism, and high expression for growth stimulating factors like IGF and IGF1R. Increased Oct3/4 expression on female own growth retardated preimplantation embryos suggests presence of totipotent cells. Commonly, basicFGF and FGF1R are the factors showing the main variations in appearance in the growth retardated embryos.