gebhart/patrepeval huggingface dataset:
Sequence of Biosynthesis of the Components of the Polyene Macrolides Candidin and Candihexin: Macrolide Aglycones as Intracellular Components (1975)

A sequential formation of the single components of the polyene macrolide candidin complex (heptaene) has been found. In addition to the three components occurring in the candidin complex at the end of the fermentation, two other "early" all-trans heptaene components have been characterized. They exist only during the phase of active biosynthesis of candidin. Two of the components of the polyene macrolide candihexin complex (hexaene) that have been described as lacking amino sugar were the only intracellular (mycelium-associated) components observed under conditions in which no extracellular polyene remained attached to the producing cell. The results indicate that glycosylation of the macrolide ring takes place during the secretion process.
Evaluation of the cytotoxicity of ventilation tube, nasal packing, and spongostan used in ear-nose-throat surgeries (2011)

Purpose: The aim of this study was to determine biocompatibility of spongostan, merocell, and ventilation tube using agar diffusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide tests in cell culture and to evaluate the results in terms of clinical practices. Materials and Methods: The experimental procedures involved in this study were approved by the Animal Ethics Committee of Cumhuriyet University (B.30.2.CUM.0.01.00-50/4), and the study was conducted following accepted guidelines for the care and use of laboratory animals for research. The present study was supported by Cumhuriyet University Scientific Research Projects (CÜBAP) Project no T-408. L929 mouse fibroblast cell culture was used in the present study. In this study, indirect toxic effects of the leakage products from the materials were tested with the agar overlay test, and also direct toxic effects of leakage materials occurring at different time and leakage products from the materials were tested with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide test. Results: As a result of evaluating the 21 days' leakage material of the ventilation tube a moderate (+2), 24 and 48 h of leakage material of the merocell low degree and 24-hour leakage material of the spongostan limited cytotoxicity were found. Conclusion: Many biomaterials cytotoxicity study were found in the literature as well as in our study shown by MTT and agar diffusion tests they were not toxic.
FBXO11 (F-box protein 11) (2017)

FBXO11 is a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, named the F-box domain. It is the substrate binding subunit of the SKP1-CUL1-F-box (SCF) ubiquitin ligase complex. FBXO11 is conserved from nematodes to mammals, and both human FBXO11 and its worm ortholog (DRE-1) form functional SCF ubiquitin ligase complexes. By binding to and mediating the degradation of its substrate proteins, FBXO11 plays important roles in regulating cell cycle regulation, tumorigenesis, and tumor cell metastasis. The gene encoding FBXO11 was found to be deleted or mutated in various types of human tumors.
Endothelial cell dysfunction and the pathogenesis of diabetic macroangiopathy (1999)

Type 2 diabetes mellitus (DM) represents a high risk condition for the development of atherosclerotic and thromboembolic macroangiopathy, which make major contributions to diabetic mortality and morbidity. While many cardiovascular risk factors are common to both atherosclerosis and Type 2 DM, the enhanced risk of diabetic macroangiopathy may be attributable to additional pro-atherogenic mediators associated with insulin resistance syndrome. Given the central pathogenic role of endotheliopathy in atherosclerosis, it is likely that this vascular monolayer is the ultimate target of injury in response to such mediators. Furthermore, a pro-oxidative, dysfunctional endothelium may actively contribute to the pro-atherogenic environment through an inappropriate regulation of vascular tone, permeability, coagulation, fibrinolysis, cell adhesion and proliferation. Such dysfunction may mediate hypertension, dyslipidaemia and altered haemostasis, in addition to aggravating in vivo insulin resistance.
Modification of Perioral Stiffness in Patients with Repaired Cleft Lip and Palate (2011)

This study demonstrates the efficacy of applying an objective measurement to map differences in perioral tissue biomechanics among patients born with orofacial clefts.
Unraveling the Role of CeO2 in Stabilization of Multivalent Mn Species on α-MnO2/Mn3O4/CeO2/C Surface for Enhanced Electrocatalysis (2021)

A hybrid heteronanostructure of α-MnO2/Mn3O4/CeO2 with the atomic-level coupled nanointerface entrenched in Vulcan carbon is reported and explored for the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER). CeO2 plays an essential role in increasing the surface Mn2+/3+/4+ in α-MnO2/Mn3O4/CeO2/C for ORR/OER processes. It shows enhanced bifunctional activity, superior to that of the benchmark 20 wt % Pt/C and Pd/C catalysts. It displays an ORR onset potential of −0.13 V (vs Ag/AgCl), limiting current density of −6.63 mA cm–2 (at 1600 rpm), mass-specific current of 47.6 mA mgMO–1 with a lower Tafel slope (921.9 mV dec–1), and an inclusive 4-e transfer involved in ORR. The OER onset potential and current density are 0.58 V (vs Ag/AgCl) and 8.45 mA cm–2 (at 0.8 V). The unique hybrid structure with oxide–oxide interface in α-MnO2/Mn3O4/CeO2 is correlated to explain the mechanistic pathway. Multistate Mn(II/III/IV) and Ce(III/IV) synergistically influence in tendering superior activity with enhanced stability.
Tensor-Dictionary Learning with Deep Kruskal-Factor Analysis (2016)

A multi-way factor analysis model is introduced for tensor-variate data of any order. Each data item is represented as a (sparse) sum of Kruskal decompositions, a Kruskal-factor analysis (KFA). KFA is nonparametric and can infer both the tensor-rank of each dictionary atom and the number of dictionary atoms. The model is adapted for online learning, which allows dictionary learning on large data sets. After KFA is introduced, the model is extended to a deep convolutional tensor-factor analysis, supervised by a Bayesian SVM. The experiments section demonstrates the improvement of KFA over vectorized approaches (e.g., BPFA), tensor decompositions, and convolutional neural networks (CNN) in multi-way denoising, blind inpainting, and image classification. The improvement in PSNR for the inpainting results over other methods exceeds 1dB in several cases and we achieve state of the art results on Caltech101 image classification.
Modern Methods of Organic Synthesis (2004)

The fourth edition of this well-known textbook discusses the key methods used in organic synthesis, showing the value and scope of these methods and how they are used in the synthesis of complex molecules. All the text from the third edition has been revised, to produce a modern account of traditional methods and an up-to-date description of recent advancements in synthetic chemistry since the previous edition. A new chapter on the functionalisation of alkenes has been included and greater emphasis on highly stereoselective reactions and radical chemistry has been placed. Reference style has been improved to include footnotes on each page, allowing easy and rapid access to the primary literature. The book will be of significant interest to chemistry and biochemistry students at advanced undergraduate and graduate level, as well as researchers in academia and industry who wish to familiarise themselves with modern synthetic methods.
Supp Table 1 from Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia (2023)

&lt;p&gt;Gene sets differentially expressed in Angpt-1 high MDS samples&lt;/p&gt;
On the generality of the Talbot condition for inducing self-imaging effects on periodic objects (2016)

Corrections to Eqs. (12) and (15) in our recent publication [Opt. Lett.41, 340 (2016)OPLEDP0146-959210.1364/OL.41.000340] are presented in this erratum.
A new stopping criterion for the Sphere Decoder in UWB impulse-radio multiple-symbol differential detection (2009)

Multiple-symbol differential detection (MSDD) is a powerful technique for power-efficient low-complexity autocorrelation receivers in ultra-wideband impulse-radio (UWBIR) systems. Since MSDD can be represented as a tree search problem, it is efficiently implemented by the sphere decoder (SD) algorithm. In this paper, we introduce a novel stopping criterion for the SD, which is based on a lower bound on the packing radius of lattices and enables early termination of the search process. As a result, the application of this stopping criterion reduces the number of search steps and thus lowers the complexity of MSDD for UWB-IR. Numerical results show that the proposed stopping criterion achieves optimal MSDD performance at reduced SD complexity.
Effects of Roux-en-Y Gastric Bypass Surgery on Fasting and Postprandial Concentrations of Plasma Ghrelin, Peptide YY, and Insulin (2005)

To help understand the mechanisms by which weight loss is maintained after Roux-en-Y gastric bypass (RYGBP), we measured circulating concentrations of total and bioactive octanoylated ghrelin, peptide YY (PYY), glucose, and insulin in the fasted state and in response to a liquid test meal in three groups of adult women: lean (n = 8); weight-stable 35 +/- 5 months after RYGBP (n = 12; mean body mass index, 33 kg/m(2)); and matched to the surgical group for body mass index and age (n = 12). Fasting plasma total ghrelin levels were nearly identical between RYGBP (425 +/- 54 pg/ml) and the matched controls (424 +/- 28 pg/ml) and highest in lean controls (564 +/- 103 pg/ml). The response to the test meal was comparable between lean and RYGBP groups, with 27% and 20% maximal suppression, respectively, whereas the magnitude of suppression was significantly diminished in the matched controls (17%) compared with the lean group. Fasting levels of octanoylated ghrelin were highest in the lean controls, 220 +/- 36 pg/ml vs. 143 +/- 27 in the RYGBP group (P = 0.05) and 127 +/- 12 pg/ml in the matched controls (P < 0.05). The magnitude of maximal postmeal suppression of octanoylated ghrelin was more marked than with total ghrelin, but similar among groups, ranging from 44-47%. In response to the test meal, there was an early exaggerated rise in PYY in the RYGBP group, such that the peak PYY concentration was 163 +/- 24 pg/ml compared with 58 +/- 17 (P < 0.01) and 77 +/- 23 (P < 0.05) in the matched and lean controls, respectively; area under the curve at 90 min was significantly greater compared with both control groups. Leptin and fasting insulin concentrations and homeostasis model of assessment insulin resistance indices were nearly identical between lean and RYGBP subjects and significantly higher in the body mass index-matched controls. In summary, the absence of a compensatory increase in ghrelin concentrations that usually occurs with diet-induced weight loss, and the exaggerated postprandial PYY response after RYGBP, may contribute to weight loss and to the ability of an individual to maintain weight loss after this surgical procedure.
Quantification of aero-optical phase distortion using the small-aperture beam technique (1995)

We discuss the small-aperture beam technique, a new way of experimentally quantifying the instantaneous optical wave front distortions imposed by propagation through an optically active, turbulent flowfield. We lay out the theoretical basis for the technique and the relationship of the measured jitter of a small-aperture probe beam to optical path difference. A numerical simulation of a two-dimensional heated jet is used to explore the validity of using beam-jitter signals from multiple probe beams to obtain optical path difference in a flow region where eddy production constitutes the major character of the turbulent flowfield.
[Single file endodontic treatment: a new era?]. (2013)

Root canal shaping is one of the key stages of endodontic treatment, when performed properly, it is a predictive factor for the outcome of the treatment. It is critical for an adequate disinfection, which is more effective at the completion of a proper shaping procedure. The introduction of NiTi instruments into endodontic greatly improved the root canal shaping and decreased the time required for a full mechanical preparation. Over the last 2 decades, numerous attempts have been made to further improve the procedure with a wide range of rotary NiTi endodontic file systems. All these systems require several subsequent files. Recently, three different concepts of single-file systems have been introduced: 1. The single file reciprocating working motion: it consists of a reciprocating counterclockwise and a clockwise motion. This reciprocal motion reduces torsional loads thus, allows safer instrumentation with less working time. 2. Single-file instrumentation using full 360 degrees rotational movement to be used in a full clockwise rotation. Some of these files also have an Anti Breakage Control (ABC) which protects from catastrophic procedural malfunction by unwinding of these file before breakage. 3. The Self-Adjusting File (SAF) which is a thin-walled, pointed cylinder, hollow nickel-titanium endodontic file that is elastically compressible into a root canal that has been previously negotiated using a #20 hand file and can widened inside it, facilitating removal of debris and dentin from the canal wall. The file conforms to the canal shape and permits irrigant flow through the file. The SAF works in a combined vibrating and partial rotational motions, and circumferentially simultaneously enlarging and irrigating the canal. The objectives of these new approaches is to reduce the working time and cost and improve safety of the shaping procedure, and suggest to have a lower procedural errors incidents. Few studies, conducted in the recent years, using these new instruments demonstrated an excellent shaping and centering ability of these new systems. They produce smooth tapered canal preparations with reproducible results, even when performed by less experienced practitioners. As mentioned above, these new techniques appeared to be promising, but further fundamental clinical and laboratory studies are needed to confirm their abilities.
Substantia nigra echogenicity is associated with serum ferritin, gender and iron-related genes in Parkinson’s disease (2020)

Substantia nigra (SN) hyperechogenicity is present in most Parkinson's disease (PD) cases but is occasionally absent in some. To date, age, gender, disease severity, and other factors have been reported to be associated with SN hyperechogenicity in PD. Previous studies have discovered that excess iron deposition in the SN underlies its hyperechogenicity in PD, which may also indicate the involvement of genes associated with iron metabolism in hyperechogenicity. The objective of our study is to explore the potential associations between variants in iron metabolism-associated genes and SN echogenicity in Han Chinese PD. Demographic profiles, clinical data, SN echogenicity and genotypes were obtained from 221 Han Chinese PD individuals with a sufficient bone window. Serum ferritin levels were quantified in 92 of these individuals by immunochemical assay. We then compared factors between PD individuals with SN hyperechogenicity and those with SN hypoechogenicity to identify factors that predispose to SN hyperechogenicity. Of our 221 participants, 122 (55.2%) displayed SN hyperechogenicity, and 99 (44.8%) displayed SN hypoechogenicity. Gender and serum ferritin levels were found to be associated with SN hyperechogenicity. In total, 14 genes were included in the sequencing part. After data processing, 34 common single nucleotide polymorphisms were included in our further analyses. In our data, we also found a significantly higher frequency of PANK2 rs3737084 (genotype: OR = 2.07, P = 0.013; allele: OR = 2.51, P = 0.002) in the SN hyperechogenic group and a higher frequency of PLA2G6 rs731821 (genotype: OR = 0.45, P = 0.016; allele: OR = 0.44, P = 0.011) in the SN hypoechogenic group. However, neither of the two variants was found to be correlated with serum ferritin. This study demonstrated that genetic factors, serum ferritin level, and gender may explain the interindividual variability in SN echogenicity in PD. This is an explorative study, and further replication is warranted in larger samples and different populations.
Ultrasmall Integrin‐Targeted Silica Nanoparticles Modulate Signaling Events and Cellular Processes in a Concentration‐Dependent Manner (2014)

Cellular and molecular-level interactions of nanoparticles with biological systems are a rapidly evolving field requiring an improved understanding of endocytic trafficking as the principal driver and regulator of signaling events and cellular responses. An understanding of these processes is vital to nanomedicine applications. Studies investigating the complex interplay of these processes and their relationship to targeted nanoparticles exploiting endocytic pathways are notably lacking. It is known that integrins traffic through the endosomal pathway and participate in diverse roles controlling signal transduction, cell migration, and proliferation. Here, it is shown that ultrasmall, nontoxic, core-shell silica nanoparticles (C-dots), surface-functionalized with cRGDY peptides, modestly activate integrin-signaling pathways, in turn, promoting the enhancement of cellular functions. First, nanomolar concentrations, two orders of magnitude higher than clinical trial doses, internalize within αvβ3 integrin-expressing melanoma and endothelial cells, predominantly through an integrin receptor-dependent endocytic route. Second, integrin-mediated activation of focal adhesion kinase (FAK) and downstream signaling pathways occurs, in turn, upregulating phosphorylated protein expression levels and promoting concentration-dependent cellular migration and proliferative activity. Inhibiting FAK catalytic activity leads to decreased phosphorylation levels and cellular migration rates. These findings may inform the design of more effectively-targeted nanomedicines and provide insights into endocytic regulation of signal transduction.
The use of P‐wave reflectivity to detect fractured sands and anisotropy clays (2001)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2001The use of P‐wave reflectivity to detect fractured sands and anisotropy claysAuthors: FatkhanMilovan UrosevicFatkhanDepartment of Exploration Geophysics, Curtin University of Technology WA Australia and Milovan UrosevicDepartment of Exploration Geophysics, Curtin University of Technology WA Australiahttps://doi.org/10.1190/1.1816302 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1816302FiguresReferencesRelatedDetailsCited ByData processing of a wide-azimuth, broadband, high-density 3D seismic survey using a low-frequency vibroseis: a case study from Northeast China25 March 2020 | Exploration Geophysics, Vol. 51, No. 6References2 October 2014 SEG Technical Program Expanded Abstracts 2001ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2001 Pages: 2135 publication data© 2001 Copyright © 2001 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 03 Jan 2005 CITATION INFORMATION Fatkhan and Milovan Urosevic, (2001), "The use of P‐wave reflectivity to detect fractured sands and anisotropy clays," SEG Technical Program Expanded Abstracts : 118-121. https://doi.org/10.1190/1.1816302 Plain-Language Summary PDF DownloadLoading ...
Characterization of calcium phosphate composite two solution bone cements (922.20) (2014)

Introduction: Acrylic bone cements are used in a variety of orthopedic applications including vertebral decompression and implant augmentation. However, they are bioinert with no ability to integrate with bone. We hypothesize that correction of this drawback can be achieved through the addition of the calcium phosphate (CaP), Brushite, providing a porous scaffold for bone interdigitation while retaining desirable mechanical, rheological, and handling properties. Methods: Composite two solution cement samples were prepared by Brushite addition yielding a pre‐mixed cement with up to 75% of the polymer replaced. Viscosity was assessed using frequency sweeps on non‐setting cements with a DHR‐3 Rheometer. Compression tests followed the ASTM F451 standard using a Bionix MTS 370. To study injectability, a pneumatic gun was used to extrude 1mL of cement through the system and the time measured. Results: CaP addition was shown to be feasible with no deleterious effect on cement mechanical properties. Rheology showed that the variation in viscosities between samples is not significant (p&lt;0.05) and pseudoplasticity was sustained. Injectability of the cement formulations varied considerably, while some showed “plugging” after the cartridge was emptied. Significance: The versatility of the pre‐mixed two solution bone cement allows for the incorporation of CaP fillers thereby enhancing interdigitation with bone. Grant Funding Source : Supported by The University of Texas System, UT Transform Award (Dr. Danieli Rodrigues)
The unconventional Di Bella cancer treatment (1999)

In less than 1 year, an evaluation of the unconventional anticancer treatment known as Di Bella Multitherapy was concluded in Italy. The need to rely on the evidence provided by clinical trials to validate a new treatment has been reaffirmed. See also pages 1887–9, 1900–2, and 2143–9.
ChemInform Abstract: Ruthenium‐Catalyzed Coupling of Oxabenzonorbornadienes with Alkynes Bearing a Propargylic Oxygen Atom: Access to Stereodefined Benzonorcaradienes. (2012)

Abstract The diastereoselectivity of the unprecedented coupling reaction depends on the presence of substituents on the bridgehead positions of the substrates.
In Situ Observation of Weld Solidification and Phase Transformation Process Using Synchrotron Radiation (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.