gebhart/patrepeval huggingface dataset:
Rac mediates actin remodeling and permeability during alveolar epithelial stretch (2011)

Alveolar epithelial cells (AECs) maintain integrity of the blood‐gas barrier via gasket‐like transcellular tight junction proteins bound to the actin cytoskeleton. AEC monolayers stretched biaxially undergo rapid actin cytoskeletal remodeling. We hypothesize that Rac1 and downstream effectors LIMK½, cofilin, Akt, and SSH1L are activated in stretched AECs. Furthermore we hypothesize that Rac1 pathway inhibition will attenuate actin remodeling and preserve paracellular permeability during AEC stretch. Primary AEC monolayers were stretched biaxially to create a change in surface area of 37% at ¼ Hz for 10 or 60 min. Additional monolayers were pretreated with Rac1 pathway inhibitors wortmannin, EHT‐1864, or IPA‐3 and stretched. Unstretched treated and untreated AECs served as two control groups. Without treatments, biaxial stretch rapidly increased Rac1, Akt, LIMK½, and cofilin activity, and resulted in rapid actin remodeling and increased monolayer permeability. Compared to stretched vehicle control monolayers, Rac1 pathway inhibitors reduced Rac1, Akt, LIMK½, and cofilin activity, attenuated actin remodeling, and preserved monolayer permeability in stretched monolayers. This study provides a foundation for developing treatment strategies aimed at reducing cellular injury during high magnitude biaxial deformation. NIH R01 HL057204
A Case of Perioperative Bacterial Meningitis Following Laparoscopic Restorative Proctocolectomy in a Patient with Ulcerative Colitis (2020)

症例は60歳の男性で，前医にて潰瘍性大腸炎（ulcerative colitis；以下，UCと略記）と診断され，内科的治療を開始したが効果に乏しく当院へ紹介となった．内科的治療不応と診断し，腹腔鏡下大腸全摘術を施行した．術後に播種性血管内凝固症候群（disseminated intravascular coagulation；以下，DICと略記）となり，その原因として当初肺炎を疑い，抗菌薬・DIC加療を施行するも発熱と意識障害の遷延を認めた．術後第63病日目に施行した頭部MRIで髄膜炎所見を認めた．さらに，髄液培養検査でEnterococcus faeciumが検出され，細菌性髄膜炎と診断した．約6週間の抗菌薬治療を継続後，発熱と意識障害は著明に改善し，再検した頭部MRI，髄液培養検査においても髄膜炎所見は消失した．今回，我々はUCに対する腹腔鏡下大腸全摘術後に極めてまれで診断に苦慮したEnterococcus faeciumによる術後細菌性髄膜炎の1例を経験したため，報告する．
A comparison of conventional spin-echo and turbo spin-echo imaging of soft tissues adjacent to orthopedic hardware. (1998)

A comparison of conventional spin-echo and turbo spin-echo imaging of soft tissues adjacent to orthopedic hardware.S Eustace, H Jara, R Goldberg, H Fenlon, M Mason, E R Melhem and E K YucelAudio Available | Share
Super-Resolution from Noisy Data (2012)

This paper studies the recovery of a superposition of point sources from noisy bandlimited data. In the fewest possible words, we only have information about the spectrum of an object in a low-frequency band bounded by a certain cut-off frequency and seek to obtain a higher resolution estimate by extrapolating the spectrum up to a higher frequency. We show that as long as the sources are separated by twice the inverse of the cut-off frequency, solving a simple convex program produces a stable estimate in the sense that the approximation error between the higher-resolution reconstruction and the truth is proportional to the noise level times the square of the super-resolution factor (SRF), which is the ratio between the desired high frequency and the cut-off frequency of the data.
Flexible Organic Light-Emitting Diodes for Automobiles (2008)

ディスプレイ用途以外にも薄型照明の検 討や，自動車用インパネ等の厳しい環境での耐久性が要求 される用途への展開も見られ，その応用範囲の広さが注目 され今後の幅広い応用展開が期待されている． ２．有機 EL ディスプレイとは
F.W. Reitz se bestaanskrisis in Nederland as onversetlike Boereleier en sy terugkeer na Suid-Afrika (1996)

F.W. Reitz's struggle for survival in the Netherlands as intransigent Boer leader and his return to South-Africa
F.W. Reitz's irreconcilable attitude towards British paramountcy in South Africa after the Anglo-Boer War led to his deportation, and unsuccessful lecturing tour through the USA (October 1902 - February 1903) and his settling in the Netherlands where his wife and children had already been living since the middle of 1900. The nature of his publications during his stay overseas, his deteriorating health, the hardship of his wife and family and their eventual decision to return to South Africa are critically discussed and analysed on the basis of archival and other sources.
F.W. Reitz se onversetlike houding teenoor Britse heerskappy in Suid-Afrika na die Anglo-Boereoorlog het gelei tot sy deportasie en 'n onsuksesvolle lesingtoer deur die VSA (Oktober 1902 - Februarie 1903) en vestiging in Nederland waar sy vrou en kinders reeds sedert die helfte van 1900 gevestig was. Die aard van sy publikasies in hierdie tyd, sy verslegtende gesondheidstoestand, die ontberings van sy vrou en gesin en hulle uiteindelike besluit om na Suid-Afrika terug te keer, word uit argivale en ander bronne krities beskryf en ontleed.
Confinement effects on optical phonons in spherical, rod‐, and tetrapod‐shaped nanocrystals detected by Raman spectroscopy (2007)

Abstract Spherical, rod‐ and tetrapod shaped CdSe nanocrystals are investigated by Raman spectroscopy and the longitudinal‐optical and surface optical phonons are observed. We find that the position of the longitudinal‐optical phonon slightly red‐shifts with decreasing diameter, whereas the position of the surface optical phonon depends significantly on diameter and length of the rods or the tetrapod arms. (© 2007 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Electrodeposition and characterization of Fe–Mo alloys as cathodes for hydrogen evolution in the process of chlorate production (2005)

Fe?Mo alloys were electrodeposited from a pyrophosphate bath using a single diode rectified AC current. Their composition and morphology were investigated by SEM, optical microscopy and EDS, in order to determine the influence of the deposition conditions on the morphology and composition of these alloys. It was shown that the electrodeposition parameters, such as chemical bath composition and current density, influenced both the composition of the Fe?Mo alloys and the current efficiency for their deposition, while the micro and macro-morphology did not change significantly with changing conditions of alloy electrodeposition. It was found that the electrodeposited Fe?Mo alloys possessed a 0.15 V to 0.30 V lower overvoltage than mild steel for hydrogen evolution in an electrolyte commonly used in commercial chlorate production, depending on the alloy composition, i.e., the conditions of alloy electrodeposition.
Development of advanced NO[sub x] control concepts for coal-fired utility boiler (1993)

Hybrid technologies for the reduction of NO[sub x] emissions from coal-fired utility boilers have shown the potential to offer greater levels of NO[sub x] control than the sum of the individual technologies, leading to more cost effective emissions control strategies. Energy and Environmental Research Corporation (EER) has developed a hybrid NO[sub x] control strategy involving two proprietary concepts which has the potential to meet the US Department of Energy's NO[sub x] reduction goal at a significant reduction in cost compared to existing technology. The process has been named CombiNO[sub x]. CombiNO[sub x] is an integration of three technologies: modified reburning, promoted selective noncatalytic reduction (SNCR) and methanol injection. These technologies are combined to achieve high levels of NO[sub x] emission reduction from coal-fired power plants equipped with S0[sub x] scrubbers. The first two steps, modified reburning and promoted SNCR are linked. It has been shown that performance of the SNCR agent is dependent upon local oxidation of CO. Reburning is used to generate the optimum amount of CO to promote the SNCR agent. Approximately 10 percent reburning is required, this represents half of that required for conventional reburning. If the reburn fuel is natural gas, the combination of reburning and SNCR may result in a significant cost savings over conventional reburning. The third step, injection of methanol into the flue gas, is used to oxidize NO to N0[sub 2] which may subsequently be removed in a wet scrubber. Pilot-scale tests performed at EER's 1 MMBtu/hr Boiler Simulation Facility (BSF) have demonstrated NO[sub x] reductions up to 92%. The program's next phase entails process scale-up to a 10 MMBtu/hr furnace also located at EER's Santa Anna test site.
Partnership for Advanced Combustion Engines (PACE) ? A Light-Duty National Laboratory Combustion Consortium. (2021)

Abstract not provided.
Research of Remote Sensing Pyramid Texture Compression in Network (2012)

摘要： 建立不同分辨率的遥感影像金字塔模型是现阶段虚拟地球平台的主要技术手段,遥感影像数据的高效压缩是模型应用的基础。论文在分析多种图像压缩技术的基础上,提出以小波变换的JPEG2000标准来压缩网络环境中遥感影像金字塔的纹理瓦片数据。首先,介绍了小波变换的JPEG2000标准的基本原理和EBCOT算法特点,然后,结合实例实现了网络环境中遥感影像金字塔纹理压缩/解压缩的具体过程,对4幅影像图像进行5级离散小波变换,分别对在1024×1024、512×512、256×256、128×128、64×64不同分块大小和1∶15、1∶30、1∶60不同压缩倍率情况下进行图像压缩和重构耗时实验,通过改变分块大小参数和压缩倍率,对压缩性能进行了对比分析,最后,从主观视觉质量和客观辐射质量,对JPEG2000压缩、DXT压缩和JPEG压缩几种方法的压缩图像进行了评价与对比分析。实验结果表明,小波变换的JPEG2000具有高质量、高压缩率、良好的抗误码能力等特性,重构图像的视觉质量与原始图像相比人眼看不出失真,而峰值信噪比较好,是一种简单有效、易于快速实现的压缩方法,更适合于网络环境下空间遥感图像数据的近无损实时压缩。
Lasers Improve Display Glass Cutting (2017)

Non‐contact glass cutting by laser offers an attractive alternative to mechanical methods in display fabrication. There are several laser technologies and processing techniques in actual use, each with its own characteristics and advantages.
Array-based comparative genome hybridisation for detection of gene copy number variation in autism : Identification of novel loci (2006)

Chromosomal abnormalities are defined as changes in the chromosome structure and fall in one of two categories. The first category is numerical alterations while the second category consists of structural abnormalities. Structural chromosomal abnormalities do not always interrupt genes in order to cause disease. They can also affect gene expression by separating a gene and its promoter element from distant regulatory elements. We have used characterisation of structural chromosomal abnormalities to identify the genetic bases for several congenital disorders.In papers I-III, we have applied molecular characterisation of chromosomal translocations in order to identify candidate genes involved in mental retardation, hypospadias and anal malformation and premature ovarian failure. In paper I, we localised the chromosome X translocation breakpoint in a t(X;15) to be in the immediate proximity of the gene ZDHHC15 in a patient with severe mental retardation. Subsequent experiments revealed loss of ZDHHC15 transcription in the patient which suggests this gene to be involved in the aetiology of the patient’s phenotype. In paper II, we show that a balanced translocation between chromosomes 6 and 17 in a patient with urogential malformation disrupts 2 genes, one at each translocation breakpoint. We also identified a fusion-gene as a result of the translocation. Our hypethesis is that the translocation together with its molecular consequences is important for the phenotype in the patient. Similarly, in paper III, we have used molecular characterisation of the breakpoints in a balanced translocation between chromosomes X and 11 in order to localise candidate genes in ovarian function. Our results indicate a number of genes affected by the translocation. In paper IV, we have used array-based comparative genomic hybridisation (array-CGH) in order to investigate a cohort of autistic sib-pairs for submicroscopic chromosomal alterations. We have identified several novel duplications and one novel deletion with strong association with autism.
Specific DNA Binding by c-Myb: Evidence for a Double Helix-Turn-Helix-Related Motif (1991)

The c-Myb protein is a sequence-specific DNA binding protein that activates transcription in hematopoietic cells. Three imperfect repeats (R1, R2, and R3) that contain regularly spaced tryptophan residues form the DNA binding domain of c-Myb. A fragment of c-Myb that contained the R2 and R3 regions bound specifically to a DNA sequence recognized by c-Myb plus ten additional base pairs at the 3' end of the element. The R2R3 fragment was predicted to contain two consecutive helix-turn-helix (HTH) motifs with unconventional turns. Mutagenesis of amino acids in R2R3 at positions that correspond to DNA-contacting amino acids in other HTH-containing proteins abolished specific DNA binding without affecting nonspecific DNA interactions.
A Hybrid Mock Circulatory Loop for Fluid Dynamic Characterization of 3D Anatomical Phantoms (2022)

The capability to reproduce physiological hemodynamics condition, with high-fidelity, plays a significant role in the cardiovascular research. The developed platform can be used to assess the performances of cardiovascular devices, to validate numerical simulations, and to test imaging systems.
Triton-Induced Hyperlipemia in Goats Under Various Physiological Conditions (1971)

Goats were given intravenous injections (.2 or .4 g per kilogram of body weight) of detergent Triton WR 1339 to measure triglyceride entry into the blood under fed, fasted, lactating, or phloridzinized and fasted conditions. Blood triglycerides increased up to 160-fold 72 hours after injection. Total cholesterol and phospholipids also increased 5 to 9-fold while free fatty acids, acetone, ketone bodies, and blood glucose were not affected by Triton injection. Fed or fasted nonlactating goats had a triglyceride entry of from .14 to .22 mg per minute per kilogram body weight. Triton was not effective in blocking triglyceride exit from the blood in fed lactating animals even though triglyceride in the plasma increased 12 to 15-fold. Milk production and milk fat composition were not changed even at the highest circulating lipid concentration. Triton had no apparent effect on the health of the goats as they ate and behaved normally.
The coronary microcirculation and coronary microvascular dysfunction (2021)

The role of revascularization in the treatment of obstructive coronary artery disease is well established, and its impact on improving survival has been proven. Nevertheless, patients with signs and symptoms considered of cardiac origin but with no obstructive coronary artery disease on coronary angiography are increasingly seen. Initially described as a ‘paradox’ or cardiac syndrome X and subsequently defined as microvascular angina, angina-like chest pain and evidence of ischaemia with non-obstructive coronary artery disease, is the consequence of altered coronary microvascular response to various stimuli despite non-obstructed epicardial vessels.
Surgical Therapy for Early Hepatocellular Carcinoma in the Modern Era (2013)

Although some patients with early HCC may not be candidates for surgical therapy, these data suggest that there is a significant missed opportunity to improve survival of patients with early HCC through the use of surgical therapy.
Anomaly Detection and Quality Evaluation of Web Applications (2008)

This chapter addresses the problem of Web application quality assessment from two perspectives. First, it shows the use of model checking of properties formulated in LTL to detect anomalies in Web applications. Anomalies can be derived from standard quality principles or defined for a specific organization or application. The detection is performed on communicating automata models inferred from execution traces. Second, the chapter explains how probabilistic models (Bayesian networks) can be built and used to evaluate quality characteristics. The structure of the networks is defined by refinement of existing models, where the parameters (probabilities and probability tables) are set using expert judgment and fuzzy clustering of empirical data. The two proposed approaches are evaluated and a discussion on how they complement each other is presented.
The Boundaries of Natural Language Processing Techniques in Extracting Knowledge from Emails (2012)

The aim of this research is to determine if natural language processing techniques can be used to fully automate the extraction of knowledge from emails. The paper reviews the five generations of building systems to share knowledge and highlights the challenges faced by all. The paper discuss the system built by the authors and shows that although the f-measure results are world leading, there is still a requirement for user intervention to enable the system to be accurate enough to be of use to an organisation.
Next Generation Photosensitive Dielectric Materials for Advanced Packaging Applications (2018)

Hitachi Chemical DuPont MicroSystems (HDMS) is a supplier of photosensitive negative-tone polyimides (PI) and positive-tone poly(benzoxazole)s (PBO) for use as protection layers in semiconductor ICs or as dielectrics for re-distribution layers in Fan-in or Fan-out wafer level packages. These materials offer an easy manufacturing process as well as ensuring high reliability in semiconductor packages. Recently, design rules and structures for next generation packages are advancing in order to achieve higher end multi-functionality. In accordance with this trend, next generation PIs and PBOs need to be developed to address new challenges that include lithographic properties, in-process compatibility and end-use properties and, in this paper, the latest material sets developed by HDMS will be introduced for advanced packaging applications. The 1st material set is a low stress photosensitive PI designed especially as a protection layer in advanced process node semiconductor ICs where warpage reduction and better protection capability for fragile low-k layers are needed. The 2nd and 3rd material sets are designed as low temperature curable photosensitive PI and PBO for use as dielectrics in Fan-out wafer level package to provide good applicability with future device designs as well as high package reliability by improving resolution, cured film properties, adhesion, insulation reliability, and others.
Sinais e sintomas na Síndrome de Costen associada a desordens temporomandibulares: relato de caso clínico (2011)

Costen’s syndrome is defined as a set of auditory signs and symptoms in patients with TMD. It is characterized by ear fullness, hearing loss, tinnitus, ear pain and vertigo with nystagmus.It has predilection for females and fourth decade of life. The multidisciplinary monitoring of these patients is imperative in its recognition and the establishment of effective therapy. In this paper we report a case of Costen’s Syndrome patient whose treatment consisted of advice on the etiology of the disorder and weekly sessions of acupuncture. The clinical features that led to the diagnosis and treatment plan, and the effectiveness of acupuncture as supportive therapy were also discussed.
Development of emotional facial recognition in late childhood and adolescence (2007)

The ability to interpret emotions in facial expressions is crucial for social functioning across the lifespan. Facial expression recognition develops rapidly during infancy and improves with age during the preschool years. However, the developmental trajectory from late childhood to adulthood is less clear. We tested older children, adolescents and adults on a two-alternative forced-choice discrimination task using morphed faces that varied in emotional content. Actors appeared to pose expressions that changed incrementally along three progressions: neutral-to-fear, neutral-to-anger, and fear-to-anger. Across all three morph types, adults displayed more sensitivity to subtle changes in emotional expression than children and adolescents. Fear morphs and fear-to-anger blends showed a linear developmental trajectory, whereas anger morphs showed a quadratic trend, increasing sharply from adolescents to adults. The results provide evidence for late developmental changes in emotional expression recognition with some specificity in the time course for distinct emotions.
Thrombotic events and mortality risk in patients with newly diagnosed polycythemia vera or essential thrombocythemia (2022)

Patients with polycythemia vera (PV) and essential thrombocythemia (ET) have increased thrombotic risk. This retrospective, real-world analysis of Medicare patients (age ≥ 65 years) newly diagnosed with high-risk PV or intermediate-/high-risk ET compared mortality risk among those with versus without thrombotic events during the study period. Patients diagnosed with PV or ET with ≥ 1 inpatient or ≥ 2 outpatient claims (January 1, 2010-December 31, 2017; index was date of first qualifying claim) were included. The study included 50,405 Medicare beneficiaries with PV and 124,569 with ET. During follow-up (median [range]: PV, 34.5 [0-97.3] months; ET, 25.5 [0-97.4] months), 14,334 patients (28.4%) with PV and 30,478 (24.5%) with ET experienced thrombotic events (most commonly ischemic stroke [PV, 46.0%; ET, 42.5%]. Mortality risk was increased for patients with versus without post-index thrombosis for both PV (adjusted hazard ratio [aHR; 95% CI], 18.6 [16.1-21.6]; P < 0.001) and ET (aHR [95% CI], 25.2 [23.1-27.5]; P < 0.001). Median survival was shorter for patients who experienced a thrombotic event ≤ 1 year post-index versus those who did not (PV, 5.1 years vs not reached; ET, 3.7 vs 6.7 years; both P < 0.001). These findings highlight the importance of thrombosis risk mitigation in PV and ET management.
Preparation of p-Toluenesulfonyl Derivatives of myo-Inositol (1971)

Abstract Six p-toluenesulfonyl esters of myo-inositol, five of which are new, have been prepared by a selective sulfonylation of myo-inositol derivatives and the structures of the new compounds were established by means of their proton magnetic resonance (PMR) spectra and the reaction sequences. Preparation of 1,3-di-O-p-toluenesulfonyl-myo-inositol, an useful intermediary compound for synthesizing myo-inosadiamine-1,3, has been improved by the present method.
A Generalized Model for the Field Assessment of Drilling Fluid Viscoelasticity (2021)

Abstract Recent studies highlight the significant role of drilling fluid elasticity in particle suspension and hole cleaning during drilling operations. Traditional methods to quantify fluid elasticity require the use of advanced rheometers not suitable for field application. The main objectives of the study were to develop a generalized model for determining viscoelasticity of a drilling fluid using standard field-testing equipment, investigate the factors influencing drilling fluid viscoelasticity in the field, and provide an understanding of the viscoelasticity concept. Over 80 fluid formulations used in this study included field samples of oil-based drilling fluids as well as laboratory samples formulated with bentonite and other polymers such as partially-hydrolyzed polyacrylamide, synthesized xanthan gum, and polyacrylic acid. Detailed rheological characterizations of these fluids used a funnel viscometer and a rotational viscometer. Elastic properties of the drilling fluids (quantified in terms of the energy required to cause an irreversible deformation in the fluid's structure) were obtained from oscillatory tests conducted using a cone-and-plate type rheometer. Using an empirical approach, a non-iterative model for quantifying elasticity correlated test results from a funnel viscometer and a rotational viscometer. The generalized model was able to predict the elasticity of drilling fluids with a mean absolute error of 5.75%. In addition, the model offers practical versatility by requiring only standard drilling fluid testing equipment to predict viscoelasticity. Experimental results showed that non-aqueous fluid (NAF) viscoelasticity is inversely proportional to the oil-water ratio and the presence of clay greatly debilitates the elasticity of the samples while enhancing their viscosity. The work efforts present a model for estimating drilling fluid elasticity using standard drilling fluid field-testing equipment. Furthermore, a revised approach helps to describe the viscoelastic property of a fluid that involves quantifying the amount of energy required to irreversibly deform a unit volume of viscoelastic fluid. The methodology, combined with the explanation of the viscoelasticity concept, provides a practical tool for optimizing drilling operations based on the viscoelasticity of drilling fluids.