gebhart/patrepeval huggingface dataset:
Immunoelectron microscopic localization of elastic tissue components in archival tissue samples (1991)

Tissue samples that have been stored for many years, in different media and under a variety of conditions, have been examined by modern techniques of immunoelectron microscopy, using antibodies against elastic tissue components. A range of postembedding restorative procedures has been identified, which will allow reliable immunolocalization of antibodies against the elastic tissue component of such specimens. These methods have been applied successfully to autopsy-derived material, fixed in buffered formaldehyde, to archival material stored frozen at -70 or -20 degrees C, to specimens fixed for electron microscopy and stored for many years in buffer, and even to archival material from formaldehyde-fixed, paraffin-embedded blocks, reprocessed for electron microscopic examination. The successful restorative methods included pre-treatment of the sections with 6 M guanidine hydrochloride, or 1 M Tris/saline, each containing 100 mM dithiothreitol (a reducing agent) followed by alkylation with 220 mM iodoacetamide. The application of these techniques allowed reliable study of elastic tissue antibody distributions in archival tissues that could not be obtained again, as well as comparative studies with tissues processed many years previously.
Removal of water-vapor-induced fluctuations in T-ray signals: a preliminary study (2007)

In an open-air setting, one source of fluctuations in a T-ray (THz) pulsed signal is attributed to water vapor. Fluctuations of this type are generally undesired, and so the water vapor is commonly removed in a closed chamber. Yet, in some applications a closed chamber is not feasible. This paper presents a preliminary study on a computational means to address the problem. Initially, the complex frequency response of water vapor is modeled from spectral line data. Using a deconvolution technique, together with fine tuning of the line strength at each frequency, the response is partially removed from a measured T-ray pulse, with minimal signal distortion.
The impact of technology scaling on soft error rate performance and limits to the efficacy of error correction (2003)

The soft error rate (SER) of advanced CMOS devices is higher than all other reliability mechanisms combined. Memories can be protected with error correction circuitry but SER in logic may limit future product reliability. Memory and logic scaling trends are discussed along with a method for determining logic SER.
Shallow Recurrent Neural Network for Personality Recognition in Source Code. (2016)

[Abstract] Personality recognition in source code constitutes a novel task in the field of author profiling on written text. In this paper we describe our proposal for the PR-SOCO shared task in FIRE 2016, which is based on a shallow recurrent LSTM neural network that tries to predict five personalityaits of the author given a source code fragment. Our preliminary results show that it should be possible to tackle the problem at hand with our approach but also that there is still room for improvement through more complex network architectures and training processes
Modulation of long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression in the liver of Beagle dogs by Toxocara canis infection (2023)

Our data provided new insight into the regulatory roles of lncRNAs and mRNAs in the pathogenesis of T. canis and improved our understanding of the contribution of lncRNAs and mRNAs to the immune and inflammatory response of the liver during T. canis infection.
Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1 (1999)

Dissecting aortic aneurysm is the hallmark of Marfan syndrome (MFS) and the result of mutations in fibrillin-1, the major constituent of elastin-associated extracellular microfibrils. It is yet to be established whether dysfunction of fibrillin-1 perturbs the ability of the elastic vessel wall to sustain hemodynamic stress by disrupting microfibrillar assembly, by impairing the homeostasis of established elastic fibers, or by a combination of both mechanisms. The pathogenic sequence responsible for the mechanical collapse of the elastic lamellae in the aortic wall is also unknown. Targeted mutation of the mouse fibrillin-1 gene has recently suggested that deficiency of fibrillin-1 reduces tissue homeostasis rather than elastic fiber formation. Here we describe another gene-targeting mutation, mgR, which shows that underexpression of fibrillin-1 similarly leads to MFS-like manifestations. Histopathological analysis of mgR/mgR specimens implicates medial calcification, the inflammatory-fibroproliferative response, and inflammation-mediated elastolysis in the natural history of dissecting aneurysm. More generally, the phenotypic severity associated with various combinations of normal and mutant fibrillin-1 alleles suggests a threshold phenomenon for the functional collapse of the vessel wall that is based on the level and the integrity of microfibrils.
A Method to Manufacture Repeatible Graphene-Based NEMS Devices at the Wafer-Scale (2016)

One of the major challenges in producing highly accurate graphene-based nanoelectromechanical (NEMS) resonators is the poor fabrication repeatability of graphene-based NEMS devices due to small variations in the residual stress and initial tension of the graphene film. This has meant that graphene-based nanoelectromechanical resonators tend to have large variations in natural frequency and quality factor from device to device. This poor repeatability makes it impossible to use these resonators to make accurate, high-precision force and displacement sensors or electromechanical filters. However, by actively controlling the tension on the graphene resonator it is possible both to increase repeatability between devices and to increase the force/mass sensitivity of the nanoelectromechanical resonators produced. Such tension control makes it possible to produce electrometrical filters that can be precisely tuned over a frequency range of up to several orders-of-magnitude. In order to controllably strain the graphene resonator, a microelectromechanical system (MEMS) is be used to apply tension to the graphene. The MEMS device consists of a graphene resonator connected between a set of gold electrodes. Each gold electrode is located on a different MEMS stage. Each stage is connected to a set of flexural bearings which are used to guide the motion of the stage. The displacement stage is actuated using a thermal actuator that allows a uniform and constant tension to be applied to the graphene resonator. The displacement of the actuator and the tension applied to the graphene are measured using a pair of differential capacitive actuators. The resonator is actuated electrostatically using the electrical back gate, and the resonant frequency is measured from the change in conductance of the graphene as it approaches resonance. Using this setup, it is possible to tune the natural frequency of the graphene resonator with high precision and accuracy. In addition to designing devices that can compensate for manufacturing errors in nanomanufactured devices, this paper will present several methods that can greatly expand the scope and rate at which nanomaterials-based devices can be fabricated. For example, this paper will present a transfer-free, wafer-scale manufacturing process that can be used to produce suspended graphene-based devices such as the graphene-based NEMS resonators. This new method involves the growth of graphene directly on the device wafer and release of the graphene-based device through etching of the copper catalyst layer. This method replaces traditional graphene fabrication methods, such as mechanical exfoliation, electron beam lithography, or transfer from copper foils, which are slow and require a transfer step that is the source of much of inconsistency in suspended graphene-based devices. Therefore, these new transfer-free, wafer-scale fabrication methods offer the potential to increase the throughput, yield, and repeatability of manufacturing processes for graphene resonators while reducing manufacturing costs and complexity.
Improving Tm3+ luminescence and tailoring nanoparticles size in silica-based optical fibers (2017)

International audience
Correlation between connex in37 C1019T polymorphism and ischemic stroke and its outcome (2012)

Objective To investigate the correlation between cornexin37 （Cx37） CI019T polymorphism and ischemic stroke and its outcome.Methods Restriction fragment length polymorphism analysis was used to detect the distribution of Cx37 C1019T polymorphism in a ischemic stroke group and a control group.The modified Rankin scale （mRS） was used to evaluate the neurological outcome at 3 months after onset.Results A total of 235 patients in the control group,and 232 patients in the ischemic stroke goup were recruited.In the ischemic stroke group,210 had a good outcome （mRS 〈3） and 22 had a poor outcome （mRS≥ 3）.The TT genotype （12.93% vs.6.39% ; x2 =10.087,P =0.006） and T allele （31.25% vs.21.49% ; x2 =11.466,P=0.001） frequency in the ischemic stroke group were significantly higher than those in the control group.Multivariatelogistic regression analysis showed that TT genotype （odds ratio [OR] 5.794; 95% confidence interval [CI] 1.405-23.894; P =0.015） and T allele （OR 131.016,95% CI 6.943 -2 472.477; P =0.001）signifkantly increased the risk of ischemic stroke.Univariate analysis showed that TT genotype （OR 0.650,95% CI 0.144 - 2,934; P =0.575）,CT genotype （OR 0.622,95% CI 0.234 - 1.655; P =0.342）,and CC genotype （OR 0.654,95% CI 0.268 - 1.595; P =0.350） had no significant correlation with the outcome of ischemic stroke.Conclusions Cx37 1019TT genotype and T allele may increase the risk of ischemic stroke.T allele is one of genetic susceptibility factors for ischemic stroke; however,its gene polymorphism is not associated with the outcome of ischemic stroke at 3 months after onset.

Key words: 
Connexins;  Polymorphism, Genetic;  Stroke;  Brain Ischemia
Application of a Logarithmic Complementary Metal–Oxide–Semiconductor Camera in White-Light Interferometry (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper describes the characterization, modeling, and application of a direct-readout complementary metal–oxide–semiconductor (CMOS) camera in white-light interferometry (WLI). The camera that was used consisted of a direct-readout 1024 <formula formulatype="inline"><tex>$\times$</tex></formula> 1024 pixel logarithmic CMOS sensor. A continuous analog voltage from each pixel was converted to an 8-bit value by an internal analog-to-digital converter and processed with a digital signal processor. A mathematical model relating the input light intensity to the 8-bit digitized output is developed, which is critical in applications where knowledge of the scene intensity is essential to estimating the maximum allowable frame rates. The camera was utilized in WLI, and its application is analyzed in terms of maximum output signal amplitude, imaging speed, and light intensity. The mathematical modeling is implemented with SPICE simulations and verified with experimental data. </para>
A Randomized, Double-Blind, Placebo-Controlled Trial of a Novel Recombinant, Humanized, Anti-Interleukin-13 Monoclonal Antibody (RPC4046) in Patients with Active Eosinophilic Esophagitis: Results of the HEROES Study (2016)

Introduction: Interleukin-13 (IL-13) has been implicated in the pathogenesis of eosinophilic esophagitis (EoE). RPC4046 prevents the binding of IL-13 to both the IL-13Ra1 and IL-13Ra2 receptors. This study evaluated the efficacy and safety of 2 dose levels of RPC4046 compared to placebo (PBO). Methods: Subjects were randomized 1:1:1 to receive either RPC4046 180 mg [LD] (n=31), RPC4046 360 mg [HD] (n=34), or PBO (n=34). An IV dose on Day 1 was followed by weekly subcutaneous doses. Esophageal biopsies, read by a central blinded pathologist, were obtained at baseline (BL) and Wk 16 to assess change in mean eosinophil count, the primary endpoint. Secondary endpoints included symptom improvement measured by a Daily Symptom Diary (DSD), improvement in endoscopic features as measured by the EoE Endoscopic Reference Score (EREF), and Subject's Global Assessment of Disease Severity. Safety was also assessed. Results: Ninety subjects completed the 16 Wk double-blind period. Demographic/disease characteristics were generally comparable between treatment arms. At BL, mean esophageal eosinophil counts (cells/hpf) were 92.4 (PBO), 116.6 (LD), and 122.6 (HD). At Wk 16, the mean count was significantly reduced from BL for both RPC4046 dose levels compared to PBO (mean change: PBO -4.4, LD -94.8, and HD -99.9 [both p < 0.0001 vs PBO]). There was a greater improvement in dysphagia symptoms as measured by the DSD with HD compared to PBO, but this did not achieve statistical significance (PBO -6.4, LD -5.3 [p=0.996 vs PBO], and HD -13.3 [p=0.073 vs PBO]). There were significant improvements in endoscopic features as determined by the reduction in the total mean EREF score with both RPC4046 dose levels (mean change: PBO -0.9, LD -4.2, and HD -4.8 [both p < 0.0004 vs PBO]). There was a significant improvement in Subject's Global Assessment of Disease Severity at the HD (PBO ?1.5, LD ?2.0, HD ?2.8 [HD p=0.0107 vs PBO]). The rates of overall adverse events (AEs) were 64.7% (PBO), 64.5% (LD), and 85.3% (HD). The most frequent AEs were headache (PBO 14.7%, LD 16.1%, HD 20.6%), upper respiratory infection (PBO 8.8%, LD 16.1%, HD 14.7%), and arthralgia (PBO 0%, LD 12.9%, HD 5.9%). Conclusion: RPC4046 demonstrated significant reductions in esophageal eosinophilic inflammation and improvements in endoscopic features at both dose levels. Subjects receiving the HD had greater symptom improvement than those on LD. These phase 2 data support the further study of RPC4046 as a novel treatment for EoE. (clinicaltrials.gov ID: NCT02098473).
The CSF-1R inhibitor Pexidartinib impacts dendritic cell differentiation through inhibition of FLT3 signaling and may antagonize the effect of durvalumab in patients with advanced cancer – results from a phase 1 study (2023)

Abstract Tumor-associated macrophages (TAM) are critical determinant of resistance to programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) blockade. This phase I study (MEDIPLEX, NCT02777710 ) investigated the safety and efficacy of pexidartinib, a CSF-1R-directed tyrosine kinase inhibitor (TKI), and durvalumab (anti-PD-L1) in patients with advanced colorectal (CRC) and pancreatic (PDAC) carcinoma with the aim to enhance responses to PD-L1 blockade by eliminating CSF-1-dependent suppressive TAM. No unexpected toxicities were observed and 2% and 15% of patients achieved partial response and stable disease respectively. Increase of CSF-1 levels and decrease of CD14 low CD16 high monocytes in peripheral blood mononuclear cells (PBMC) confirmed CSF-1R engagement. Treatment significantly decreased blood dendritic cell (DC) subsets and impaired IFN-λ/IL-29 production by type-1 conventional DC in ex vivo TLR3-stimulated PBMC. Pexidartinib also targets c-KIT and FLT3, both key growth factor receptors of DC development and maturation. In patients, FLT3-L levels increased with pexidartinib treatment. In vitro , pexidartinib impaired the FLT3-L but not GM-CSF-dependent generation of DC subsets from murine bone marrow progenitors. Our results demonstrate that pexidartinib, through the inhibition of FLT3 signaling, has deleterious effect on DC differentiation, which may explain the limited anti-tumor clinical activity observed in this study. This study suggests that inhibition of FLT3 should be taken into account when combining TKIs with immune checkpoint blockers. One-sentence summary Pexidartinib affects the development of dendritic cells
Percutaneous Repair of Secondary Mitral Regurgitation — A Tale of Two Trials (2018)

The mitral valve is a complex structure encompassing the valve leaflets, annulus, chordae tendineae, and papillary muscles.1 Primary mitral regurgitation is caused by a primary leaflet abnormality, whereas secondary mitral regurgitation occurs when structurally normal valve leaflets are unable to coapt completely owing to distortion of the supporting apparatus resulting from an ischemic or dilated cardiomyopathy. Current guidelines recommend early surgery for severe primary mitral regurgitation,2,3 but the management of secondary mitral regurgitation, which is essentially a disease of the left ventricle, is more controversial. Patients who have left ventricular dysfunction and secondary mitral regurgitation of any severity have a . . .
Correction to “Electron Transfer Going the Distance: Mn-Doped ZnSe as Model Photocatalytic Systems” (2022)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Electron Transfer Going the Distance: Mn-Doped ZnSe as Model Photocatalytic Systems"Kelsey M. WatsonKelsey M. WatsonMore by Kelsey M. Watson and John B. Asbury*John B. AsburyMore by John B. Asburyhttps://orcid.org/0000-0002-3641-7276Cite this: J. Phys. Chem. C 2022, 126, 4, 2299Publication Date (Web):January 24, 2022Publication History Published online24 January 2022Published inissue 3 February 2022https://pubs.acs.org/doi/10.1021/acs.jpcc.2c00385https://doi.org/10.1021/acs.jpcc.2c00385correctionACS PublicationsCopyright © 2022 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views345Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (906 KB) Get e-Alertsclose Get e-Alerts
ChemInform Abstract: 1‐Amino‐2‐chloromethylene‐2,3‐dihydropyrroles by Unusual Reaction of Conjugated Azoalkenes with 2‐Chloro‐1,3‐dicarbonyl Compounds. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Slot Tagging for Task Oriented Spoken Language Understanding in Human-to-Human Conversation Scenarios (2019)

Task oriented language understanding (LU) in human-to-machine (H2M) conversations has been extensively studied for personal digital assistants. In this work, we extend the task oriented LU problem to human-to-human (H2H) conversations, focusing on the slot tagging task. Recent advances on LU in H2M conversations have shown accuracy improvements by adding encoded knowledge from different sources. Inspired by this, we explore several variants of a bidirectional LSTM architecture that relies on different knowledge sources, such as Web data, search engine click logs, expert feedback from H2M models, as well as previous utterances in the conversation. We also propose ensemble techniques that aggregate these different knowledge sources into a single model. Experimental evaluation on a four-turn Twitter dataset in the restaurant and music domains shows improvements in the slot tagging F1-score of up to 6.09% compared to existing approaches.
Surface Ultrastructure of Gram (−) Bacteria: I. Discrimination Between Gram (+) and Gram (−) Cells by Electron Microscopy (1974)

A modified negative staining technique (Osmium Tetroxide-Phosphotungstate procedure; OTPT) allows a detailed visualization and differentiation of the surface topography of Gram (+) and Gram (−) bacteria. All of the Gram (−) organisms studied exhibited a highly convoluted surface distinct from the apparently smooth surface of Gram (+) cells.
Band-Drive Suspension Mechanism Design for Ground-Based Testing of Flexible Space Structures (1995)

A suspension system based on a band mechanism is investigated to provide the free-free conditions for ground-based validation testing of flexible space structures. The band mechanism consists of a noncircular disk with a convex profile, preloaded by torsional springs at its center of rotation so that static equilibrium of the test structure is maintained at any vertical location; gravitational force will be directly counteracted during dynamic testing of the space structure. This noncircular disk within the suspension system can be configured to remain unchanged for test articles with different weights as long as the torsional spring is replaced to maintain the originally designed frequency parameter of W/ks Simulations of test articles which are modelled as lumped-parameter as well as continuous parameter systems are also presented.
Detecting Altered Postural Control After Cerebral Concussion in Athletes Without Postural Instability (2004)

1418 Athletes with mild traumatic brain injury (MTBI), i.e., cerebral concussion, may be vulnerable to further injury if returning to competition before complete neurological recovery. Although postural instability is a valid marker of altered function, some injured athletes who report disequilibrium remain clinically stable. We questioned whether measuring only the magnitude of postural sway after injury provides a sufficient indication of normal postural control. PURPOSE: To determine if postural control changes after MTBI could be detected among athletes without postural instability. METHODS: We analyzed anterior-posterior center of pressure (COP) time series collected during the Sensory Organization Test (SOT) from 14 male and 3 female college athletes tested at two different sessions: a) preseason, and b) within 48 hours after MTBI. For testing, subjects stood still during 20-second trials in 6 sensory conditions. After injury, each subject had a clinically normal SOT Composite Equilibrium Score that was no more than 5% below preseason values. Approximate Entropy (ApEn), a tool from nonlinear dynamics, was used to quantify the regularity of COP oscillations in the SOT data. ApEn produces real numbers from 0–2, with lower values indicating less erratic, more regular fluctuations in the COP time series. For each SOT condition, ApEn scores (m = 2, r = 0.2 × series s.d., N = 2000, lag 10) from Trials 1 & 2 were averaged and group means were tested with a Student t-test (α = 0.05) to evaluate differences between sessions. RESULTS: Compared to preseason, mean ApEn values declined after MTBI in each SOT condition. Significant differences were found between sessions for SOT Condition 2 (difference = 0.13, t[16] = 2.64, p = 0.018) and Condition 4 (difference = 0.11, t[16] = 2.42, p = 0.028). CONCLUSIONS: ApEn detected an increase in the regularity of COP fluctuations after MTBI in the absence of postural instability. Changes were consistent with reduced control system degrees of freedom and were more apparent in SOT conditions emphasizing use of somatosensory and visual cues. ApEn seems to be a useful tool for evaluating changes in postural control after MTBI and may serve as a valuable supplemental indicator for return to competitive activity.