gebhart/patrepeval huggingface dataset:
Long-term coronary stenosis in rats: cardiac performance, myocardial morphology, and contractile protein enzyme activity (1992)

To determine the effects of chronic nonocclusive coronary constriction on cardiac hemodynamics, myocardial structure, and contractile protein enzyme activity, the left coronary artery was narrowed in rats, and measurements of ventricular pump function, extent and localization of tissue damage, and myofibrillar Mg2+ and Ca2+ myosin adenosinetriphosphatase (ATPase) activities were measured 3 mo later. In the presence of coronary artery stenosis averaging 56%, two different degrees of depression in global cardiac performance were identified, and the animals were divided in two groups. In the first group, left ventricular end-diastolic pressure (LVEDP) was increased and LV+ and/or--the first derivative of LV pressure (dP/dt) were decreased, whereas in the second group end-diastolic and peak systolic LV pressures, LV+ and -dP/dt and right ventricular dynamics were all impaired. Thus left ventricular dysfunction and failure occurred with coronary narrowing. Structurally, multiple foci of replacement fibrosis were found across the left ventricular wall, but the number of these lesion profiles was 2.6-fold larger in failing animals than in rats with cardiac dysfunction. Biochemically, Mg(2+)-ATPase activity in myofibrils and Ca2+ myosin ATPase were not altered biventricularly. On the other hand, a shift from V1 to V3 myosin isoenzymic content occurred in the failing left ventricle. In conclusion, the late impairment in ventricular pump function associated with prolonged coronary artery stenosis appears to be sustained more by the magnitude of myocardial damage than by defects in contractile protein enzyme activity.
Influence of annealing atmosphere on the performance of a β-Ga2O3 thin film and photodetector (2018)

β-Ga2O3 epitaxial thin films were deposited by laser molecular beam epitaxy (LMBE) and annealed at 800°C for 30 minutes in air and oxygen atmospheres, respectively. Photodetectors were fabricated using as-grown and annealed Ga2O3 epilayers. The influence of the annealing atmosphere on the crystal structure and optical properties of Ga2O3 films was investigated. X-ray diffraction (XRD) measurements show that the in-plane compressive strain of Ga2O3 thin films could be relaxed after high temperature thermal annealing. Compared with the as-grown sample, the annealed samples exhibit a red shift of absorption edge in the transmittance spectra, indicating a reduced bandgap. According to the XPS measurement results, the atomic ratios of O to Ga also increased for the annealed samples. Moreover, the oxygen-annealed photodetector achieves a larger photocurrent, higher responsivity and better time-dependent photoresponse than the other two samples, which may be attributed to the decrease in the number of oxygen vacancies.
Nonpeptide Factor Xa Inhibitors: DPC423, a Highly Potent and Orally Bioavailable Pyrazole Antithrombotic Agent (2002)

DPC423, 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide, is a synthetic, orally bioavailable, competitive, and selective inhibitor of human coagulation factor Xa (K(i) [nM]: factor Xa, 0.15; trypsin, 60; thrombin, 6000; plasma kallikrein, 61; activated protein C, 1800; factor IXa, 2200; factor VIIa, >15,000; chymotrypsin, >17,000; urokinase, >19,000; plasmin, >35,000; tissue plasminogen activator, >45,000; complement factor I, 44,000 [IC(50)]). In vitro, DPC423 produced anticoagulant effects in human plasma in which it doubled prothrombin time, activated partial thromboplastin time, and Heptest clotting time at 3.1 +/- 0.4, 3.1 +/- 0.4, and 1.1 +/- 0.5 microM, respectively. In dogs, DPC423 had a good pharmacokinetic profile with an oral bioavailability of 57%, a plasma clearance of 0.24 L/kg/h, and a plasma half-life of 7.5 h. In rabbit and rat models of arteriovenous shunt thrombosis, DPC423 was an effective antithrombotic agent with an IC(50) of 150 and 470 nM, respectively. The antithrombotic effect of DPC423 is likely to be related to the inhibition of factor Xa but not to the inhibition of thrombin or due to direct inhibition of platelet aggregation. Therefore, based on potency, selectivity, efficacy, and oral bioavailability, DPC423 was selected for clinical development as an oral anticoagulant for the potential treatment of thrombotic disorders. Preliminary human data suggest that DPC423 is orally bioavailable in humans and has a long plasma half-life.
Proposal of using EUVL for PXL (2004)

A new idea of writing a PXL (Proximity X-ray Lithography) mask is presented, in which a EUVL (extreme ultraviolet lithography) exposure tool is used as a mask repeater. EUV power of less than 1W is enough to write a PXL mask within 5 minutes, and an expensive EUV mask blank can be recycled because the mother mask is not necessary once a PXL mask is written. A EUV mask repeater especially consisting of a high-NA Micro Exposure Tool (MET) makes it possible to write a PXL mask for the 32 nm nodes and after. The new system can also be applied to other lithography tools using a 1X: such as LEEPL (Low Energy E-Beam Proximity Lithography) and imprint lithography.
From curiosities to commodities: ionic liquids begin the transition (2003)

A growing variety of ionic liquids are becoming commercially available, a development that will feed the surge of research using these unorthodox liquids.
Searching for better plasmonic materials (2010)

Abstract Plasmonics is a research area merging the fields of optics and nanoelectronics by confining light with relatively large free‐space wavelength to the nanometer scale ‐ thereby enabling a family of novel devices. Current plasmonic devices at telecommunication and optical frequencies face significant challenges due to losses encountered in the constituent plasmonic materials. These large losses seriously limit the practicality of these metals for many novel applications. This paper provides an overview of alternative plasmonic materials along with motivation for each material choice and important aspects of fabrication. A comparative study of various materials including metals, metal alloys and heavily doped semiconductors is presented. The performance of each material is evaluated based on quality factors defined for each class of plasmonic devices. Most importantly, this paper outlines an approach for realizing optimal plasmonic material properties for specific frequencies and applications, thereby providing a reference for those searching for better plasmonic materials.
Code generation using tree matching and dynamic programming (1989)

Compiler-component generators, such as lexical analyzer generators and parser generators, have long been used to facilitate the construction of compilers. A tree-manipulation language called twig has been developed to help construct efficient code generators. Twig transforms a tree-translation scheme into a code generator that combines a fast top-down tree-pattern matching algorithm with dynamic programming. Twig has been used to specify and construct code generators for several experimental compilers targeted for different machines.
Synthesis and properties of self‐protecting polyarylates (1969)

Abstract Self‐protective polyesters were synthesized in two ways: by polymer analog transformations on polymers obtained and by introduction of inhibiting groups into the polymer during synthesis. It is shown that the Fries rearrangement takes place in the aromatic polyesters in the presence of the Friedel‐Crafts catalysts and on ultraviolet irradiation as well. Thermogravimetric analysis of the rearranged polymers and investigations of the influence of the ultraviolet irradiation on their properties show that the rearrangement markedly increases the photochemical and thermal stability of the polymers. Photostabilization may also be accomplished by the introduction of inhibiting groups, such as hydroxyl, sulfur, or phosphorus into the polymer molecule.
Observations and preliminary science results from the first 100 sols of MSL Rover Environmental Monitoring Station ground temperature sensor measurements at Gale Crater (2014)

Abstract We describe preliminary results from the first 100 sols of ground temperature measurements along the Mars Science Laboratory's traverse from Bradbury Landing to Rocknest in Gale. The ground temperature data show long‐term increases in mean temperature that are consistent with seasonal evolution. Deviations from expected temperature trends within the diurnal cycle are observed and may be attributed to rover and environmental effects. Fits to measured diurnal temperature amplitudes using a thermal model suggest that the observed surfaces have thermal inertias in the range of 265–375 J m −2 K −1 s −1/2 , which are within the range of values determined from orbital measurements and are consistent with the inertias predicted from the observed particle sizes on the uppermost surface near the rover. Ground temperatures at Gale Crater appear to warm earlier and cool later than predicted by the model, suggesting that there are multiple unaccounted for physical conditions or processes in our models. Where the Mars Science Laboratory (MSL) descent engines removed a mobile layer of dust and fine sediments from over rockier material, the diurnal temperature profile is closer to that expected for a homogeneous surface, suggesting that the mobile materials on the uppermost surface may be partially responsible for the mismatch between observed temperatures and those predicted for materials having a single thermal inertia. Models of local stratigraphy also implicate thermophysical heterogeneity at the uppermost surface as a potential contributor to the observed diurnal temperature cycle.
Catalytic performance of NiO nanoparticles decorated carbon nanotubes via one-pot laser ablation method against methyl orange dye (2022)

NiO-CNTs nanocomposite was prepared by the decoration of CNTs by NiO nanoparticles via eco-friendly pulsed laser ablation method based on nanosecond Nd:YAG laser to be applied in the removal of methyl orange (MO) dye. The preparation and the decoration of NiO nanoparticles were carried out in a single step without any by-product via pulsed laser ablation method. The nanocomposite was characterized by different analytical techniques such as FT-IR, TEM, XRD, Raman spectroscopy, XPS, and EDX. These techniques confirmed the formation of NiO in the nanoscale range (spherical shape) with a particle size of about 20 nm without the formation of any other by-product. Moreover, the examination of the interaction between NiO nanoparticles and CNTs showed a shift in their peaks, while the examination of its surface showed an increase in the amounts of defects and appearance of spherical shape from NiO on the surface of CNTs. Then, the efficiency of removal MO was investigated in visible light in the absence of any reducing agent with the assistance of the prepared nanocomposite to investigate the capability to be used as adsorbent materials. The results showed a high adsorption ability of NiO-CNTs nanocomposite against MO due to both, the large surface area of CNTs and the catalytic activity of NiO nanoparticles.
Supplemental Figure Legends from Circulating Tumor DNA as an Early Indicator of Response to T-cell Transfer Immunotherapy in Metastatic Melanoma (2023)

&lt;p&gt;Fig. S1. castPCR{trade mark, serif} design, analytical sensitivity and specificity, and cfDNA measurements Fig. S2. Mutational analysis of tumor specimens from 93 NCI TIL patients Fig. S3. Cases excluded from pattern analysis&lt;/p&gt;
Modeling and Deployment of Model-Based Decentralized Embedded Diagnosis inside Vehicles: Application to Smart Distance Keeping Function (2012)

The deployment of a fault diagnosis strategy in the Smart Distance Keeping (SDK) system with a decentralized architecture is presented. The SDK system is an advanced Adaptive Cruise Control (ACC) system implemented in a Renault-Volvo Trucks vehicle to increase safety by overcoming some ACC limitations. One of the main differences between this new system and the classical ACC is the choice of the safe distance. This latter is the distance between the vehicle equipped with the ACC or the SDK system and the obstacle-in-front (which may be another vehicle). It is supposed fixed in the case of the ACC, while variable in the case of the SDK. The variation of this distance depends essentially on the relative velocity between the vehicle and the obstacle-in-front. The main goal of this work is to analyze measurements, issued from the SDK elements, in order to detect, to localize, and to identify some faults that may occur. Our main contribution is the proposition of a decentralized approach permitting to carry out an on-line diagnosis without computing the global model and to achieve most of the work locally avoiding huge extra diagnostic information traffic between components. After a detailed description of the SDK system, this paper explains the model-based decentralized solution and its application to the embedded diagnosis of the SDK system inside Renault-Volvo Truck with five control units connected via a CAN-bus using “Hardware in the Loop” (HIL) technique. We also discuss the constraints that must be fulfilled.
Detecção de resíduos de substâncias com ação antimicrobiana nos leites UAT e pasteurizado comercializados no município de Itabuna-Bahia (2016)

The milk is a rich food in nutritious and very important in the diet. The incidence of residues of antimicrobial in the milk can bring serious risks to the collective health, besides bringing damages to the industry of dairy products. They were analyzed 100 samples of UHT milk of 17 different marks and 100 samples of pasteurized milk of three different marks marketed in the principal retail establishments of the city of Itabuna-BA. It was realized the test of inhibition of bacterial growth with the test bacterias Escherichia coli and Bacillus subtilis sowed in Agar Mueller Hinton and the formation of halo of inhibition was observed around the filter papers plunged into the samples of milk. In the UHT milk, 34% positive samples were detected, being 8% for Escherichia coli, 7% for Bacillus subtilis and 19% for both of them. Already in the pasteurized milk, 27% positive samples were detected, being 7% for Escherichia coli, 11% for Bacillus subtilis and 9% for both. It was observed a high frequency of residue of antibiotic in the milk samples studied, being necessary to increase the inspection by the responsible organs and to carry out educative campaigns showing the risks caused by the presence of these residues in the consumed milk and, with that, to look how to improve the quality of the UHT milk and Pasteurized milk sold in the investigated region.
The Mechanical and Electronic Properties of Carbon-related Nanoscale Materials: Ab Initio Study (2009)

The mechanical and electronic properties of the nanoscale materials are studied using ab initio molecular dynamics (TBMD) method. We investigate the strength and fracture behaviors of nanoscale materials like carbon nanotubes (CNT), graphens and nanowires in comparison with those of corresponding bulk materials. The elastic properties, yield strength and fracture behaviors of carbon-related nanomaterials are studied in detail, using the constraint MD method based on the lattice Green's function method. We will show that the strength properties of the nanoscale materials are quite different from those of the corresponding bulk materials. The electronic density of states and electronic transports of the nanomaterials, with and without the atomistic defects (nano cracks), are also discussed.
The Electrochromic Properties of Thermally Decomposed Films of an Organic Tungsten Compound (1981)

The electrochromic properties of thermally decomposed films of an organic tungsten compound are investigated. The films are prepared by spin-coating a toluene solution of hexaphenoxy-tungsten onto transparent conductive substrates and thermally decomposing the coated films in air. Films decomposed at relatively low temperatures (about 200°C) show good electrochromic properties, comparable to ordinary vacuum evaporation films. The write-erase property of the film becomes poorer as the decomposition temperature is increased. This degradation is due mainly to crystallization of the tungsten oxide.
MIMO Two-way Relay Channel: Diversity-Multiplexing Tradeoff Analysis (2008)

A multi-hop two-way relay channel is considered in which all the terminals are equipped with multiple antennas. Assuming independent quasi-static Rayleigh fading channels and channel state information available at the receivers, we characterize the optimal diversity-multiplexing gain tradeoff (DMT) curve for a full-duplex relay terminal. It is shown that the optimal DMT can be achieved by a compress-and-forward type relaying strategy in which the relay quantizes its received signal and transmits the corresponding channel codeword. It is noteworthy that, with this transmission protocol, the two transmissions in opposite directions can achieve their respective single user optimal DMT performances simultaneously, despite the interference they cause to each other. Motivated by the optimality of this scheme in the case of the two-way relay channel, a novel dynamic compress-and-forward (DCF) protocol is proposed for the one-way multi-hop MIMO relay channel for a half-duplex relay terminal, and this scheme is shown to achieve the optimal DMT performance.
Electron Bombardment Damage in Silicon Esaki Diodes (1961)

The excess current in silicon Esaki diodes has been shown to be a sensitive indicator of the density and distribution of states intorduced into the forbidden gap by electron bombardment. Both the effects of bombardment and the annealing properties of the radiation damage have been found to depend upon the specific donor in the n-type region of the diode. The average bombardment dose of 1-Mev electron/cm2 needed to increase the excess current density by 1 amp/cm2 at a bias of 0.3 v is 1.2×1016 for P-doped diodes and 0.8×1016 for Sb- or As-doped diodes. Upon annealing in an inert atmosphere, at temperature in the range 300°–400°C, the bombarded diode is restored to its original characteristics. While the annealing studies reveal novel interactions, they show considerable similarity with other work where the radiation damage was monitored by carrier lifetime or conductivity measurements. Structures observed in the I–V characteristics during the annealing indicate that the bombardment-induced levels at Ev+0.27 and Ev+0.06 are due to pairing of a primary defect (probably a vacancy) with an arsenic and a phosphorus impurity atom, respectively.
A new biotecnological-based iron-fertilizer formulation for environmental sustainable correction of chlorosis of soybean plants grown in calcareous soils (2019)

[Excerpt] Iron (Fe) is an essential element for the proper development of life. Plants require Fe for chlorophyll synthesis. However, due to the lack of Fe, plants grown in alkaline calcareous soils are very susceptible to a symptomatic array named iron-deficiency induced chlorosis (IDIC). The inappropriate chlorophyll production results in the reduction of crop yields with major implications in many agricultural regions worldwide. Organic chelating agents, namely aminopolycarboxylic acids (APCAs), are adequate for IDIC amending. However, the low biodegradability of such compounds raises several environmental concerns. Therefore, the replacement of APCAs by new more environment-friendly alternatives is needed. [...]
Efficient Production of Bovine Tetraploid Embryos by Electrofusion of In Vitro Produced Two-Cell Stage Embryos (2016)

Tetraploid complementation has been used to improve the production of cloned animals. The main objective of this study was to improve the efficiency of bovine tetraploid embryo production and the development potential of bovine tetraploid embryos into blastocysts. We assessed early embryonic cleavage timing and established the defined time quantum to collect synchronous 2-cell stage bovine embryos for electrofusion. Different electrofusion protocols were also tested. The second aim was to monitor ploidy transition by fluorescence visualization to shed lights on the nuclear fusion process of the cytoplasmic membrane-fused 2-cell stage bovine embryos. Karyotypes of day 8 blastocysts (day 0: day of electrofusion) were determined by karyotyping analysis. We found that electrofusion of in vitro produced bovine 2-cell stage embryos results in both tetraploid and diploid embryos and that blastocyst formation rates from fused 2-cell stage embryos are affected by the number of electrofusion pulses and the timing of how soon the 2-cell stage embryos are formed post insemination. We identified two distinct nuclear configurations after electrofusion of 2-cell stage embryos, each of which is uniquely related to the formation of tetraploid or diploid embryos. Based on the observation that tetraploid and diploid embryos derived from fused 2-cell stage embryos undergo different timings to become 2-cell stage embryos again, diploid and tetraploid 2-cell embryos can be readily separated after electrofusion. Finally, our study established an experimental protocol for the effective production of bovine tetraploid embryos by electrofusion of 2-cell embryos.
Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors (2021)

It remains unresolved how retinal pigment epithelial cell metabolism is regulated following immune activation to maintain retinal homeostasis and retinal function. We exposed retinal pigment epithelium (RPE) to several stress signals, particularly Toll-like receptor stimulation, and uncovered an ability of RPE to adapt their metabolic preference on aerobic glycolysis or oxidative glucose metabolism in response to different immune stimuli. We have identified interleukin-33 (IL-33) as a key metabolic checkpoint that antagonizes the Warburg effect to ensure the functional stability of the RPE. The identification of IL-33 as a key regulator of mitochondrial metabolism suggests roles for the cytokine that go beyond its extracellular "alarmin" activities. IL-33 exerts control over mitochondrial respiration in RPE by facilitating oxidative pyruvate catabolism. We have also revealed that in the absence of IL-33, mitochondrial function declined and resultant bioenergetic switching was aligned with altered mitochondrial morphology. Our data not only shed new light on the molecular pathway of activation of mitochondrial respiration in RPE in response to immune stressors but also uncover a potentially novel role of nuclear intrinsic IL-33 as a metabolic checkpoint regulator.