gebhart/patrepeval huggingface dataset:
The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway (2022)

Although hair loss is not a horrible disease, it sometimes reduces the patients' quality of life (QOL) and increases their mental stress. Currently, there is no effective treatment for hair loss. It is known that honeybee propolis has various biological activities, including stimulating the proliferation of hair matrix keratinocytes. However, little is known with the hair promoting activity of stingless bee propolis. Hence, this study investigates the hair growth-promoting activity of Philippines stingless bee propolis extract and the underlying a molecular mechanism of promoting hair growth. For the evaluation of hair growth stimulating activity, 99.5% ethanolic extract of Philippines stingless bee propolis is examined using the simple shaving model in C57BL/6N mice. Melaninization of dorsal skin and histological analysis of hair follicles (HFs) revealed that propolis promotes hair growth by stimulating HFs development. The expression of mRNA (Wnt3a, Ctnnb1/β-catenin, Lef1, and Bmp2) and protein (WNT3A and β-catenin) of selected Wnt/β-catenin associated genes explains Philippines stingless bee propolis promoting HFs development by activating Wnt/β-catenin signaling pathway. These results suggest that the treatment of propolis strongly promotes hair growth by stimulating the development of HFs via activation of Wnt/β-catenin signaling pathway. This further indicates the potential of Philippines stingless bee propolis as a novel promising agricultural product for hair growth.
Brc1-Mediated Rescue of Smc5/6 Deficiency: Requirement for Multiple Nucleases and a Novel Rad18 Function (2007)

Smc5/6 is a structural maintenance of chromosomes complex, related to the cohesin and condensin complexes. Recent studies implicate Smc5/6 as being essential for homologous recombination. Each gene is essential, but hypomorphic alleles are defective in the repair of a diverse array of lesions. A particular allele of smc6 (smc6-74) is suppressed by overexpression of Brc1, a six-BRCT domain protein that is required for DNA repair during S-phase. This suppression requires the postreplication repair (PRR) protein Rhp18 and the structure-specific endonucleases Slx1/4 and Mus81/Eme1. However, we show here that the contribution of Rhp18 is via a novel pathway that is independent of PCNA ubiquitination and PRR. Moreover, we identify Exo1 as an additional nuclease required for Brc1-mediated suppression of smc6-74, independent of mismatch repair. Further, the Apn2 endonuclease is required for the viability of smc6 mutants without extrinsic DNA damage, although this is not due to a defect in base excision repair. Several nucleotide excision repair genes are similarly shown to ensure viability of smc6 mutants. The requirement for excision factors for the viability of smc6 mutants is consistent with an inability to respond to spontaneous lesions by Smc5/6-dependent recombination.
Structural Investigation on the Poly(vinylpyrrolidone)−Water System in the Presence of Sodium Decyl Sulfate and Sodium Decanesulfonate:  A Small Angle Neutron Scattering Study (2004)

Small angle neutron scattering (SANS) has been used to study the interaction of sodium decyl sulfate (C10OS) and sodium decanesulfonate (C10S) with poly(vinylpyrrolidone) (PVP). The measurements were performed on aqueous solutions of C10OS and C10S in the presence and absence of PVP. In all ternary systems the polymer concentration was kept constant at 1 wt %, and the surfactant molal concentration ranged from 0.002 to 0.150 mol kg-1. The analysis of the collected SANS profiles confirms the absence of any appreciable interaction between PVP and C10S in contrast with what observed for the PVP−C10OS−D2O system. In this latter system, in fact, a clear interaction peak in the scattering pattern appears well below the cmc of the surfactant, which suggests a complex formation between PVP and C10OS. The preferential interaction of poly(vinylpyrrolidone) toward sodium decyl sulfate with respect to sodium decanesulfonate reflects the difference in the chemical structure of the two surfactants that produces meaningful differences in the values of their cmc and aggregation number, as shown by the results here presented.
Isolation of Legionella pneumophila from clinical specimens via amoebae, and the interaction of those and other isolates with amoebae. (1983)

The development of an amoebal enrichment method, for the recovery of viable Legionella pneumophila from clinical materials is described. The method has been used successfully in five of six cases of Legionnaires' disease in which L pneumophila was isolated. Studies on those L pneumophila isolates led to the discovery that virulent legionellae are attracted to, and attack suitable host amoebae, rather than infection following chance ingestion.
Quantitative determination of glycerol in antarctic krill (Euphausia superba Dana) by high-performance thin-layer chromatography (2017)

In this reported study, a direct high-performance thin-layer chromatographic (HPTLC) method was developed to qualitatively detect and quantitatively determine glycerol in Antarctic krill for the first time. This procedure was based on the extraction of glycerol by ultrasonic solvent extraction with anhydrous ethanol, silica-gel column chromatographic separation, HPTLC detection and quantification using methylene chloride–methanol (5:1, v/v) as the developing solvent and alkaline potassium permanganate as chromogenic agent. The content of glycerol was 1.3725 ± 0.218 mg/g in freeze-dried Antarctic krill. The structure of glycerol in the Antarctic krill was subsequently determined by gas chromatography–mass spectrometry (GC–MS) which verified the presence of the material in the krill. The HPTLC method exhibited excellent accuracy with a recovery of 90.1–103.3% and good precision with a relative standard deviation (RSD) of 1.59–4.84%. The results clearly exhibited the applicability of the proposed for quantifying glycerol in Antarctic krill.
La Buprenorphine (Subutex), Nouveau Traitement de Substitution des Heroinomanes (1997)

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Réduction de la pollution par plasma-catalyse: Cas des composés organiques volatiles (COV) et des oxydes d'azote (NOx). (2009)

National audience
Statistics: A Guide to the Use of Statistical Methods in the Physical Sciences (1991)

Using Statistics. Describing the Data. Theoretical Distributions. Errors. Estimation. Least Squares. Probability and Confidence. Taking Decisions. Ranking Methods. Notes for Number Crunchers. Bibliography. Appendices. Index.
Metal-catalysed oxidation of acetylenes and diazo-ketones (1973)

The molybdenum-catalysed oxidation of acetylenes and the metal-catalysed decompositions and oxidations of α-diazo-ketones appear to proceed via transient metal–oxocarbene complexes. The formation of oxirens as intermediates in these reactions is excluded. The initial product from these oxidations is the corresponding α-diketone.
Genetic ancestry, skin color and social attainment: The four cities study (2020)

Our findings suggest differences in skin pigmentation by geography and support regional variations in ancestry of US Blacks. Biomedical research should consider genetic ancestry and local historical/social context rather than relying solely on skin pigmentation as a proxy for race.
Nematicidal activity of essential oils and volatiles derived from Portuguese aromatic flora against the pinewood nematode, Bursaphelenchus xylophilus. (2010)

Twenty seven essential oils, isolated from plants representing 11 families of Portuguese flora, were screened for their nematicidal activity against the pinewood nematode (PWN), Bursaphelenchus xylophilus. The essential oils were isolated by hydrodistillation and the volatiles by distillation-extraction, and both were analysed by GC and GC-MS. High nematicidal activity was achieved with essential oils from Chamaespartium tridentatum, Origanum vulgare, Satureja montana, Thymbra capitata, and Thymus caespititius. All of these essential oils had an estimated minimum inhibitory concentration ranging between 0.097 and 0.374 mg/ml and a lethal concentration necessary to kill 100% of the population (LC(100)) between 0.858 and 1.984 mg/ml. Good nematicidal activity was also obtained with the essential oil from Cymbopogon citratus. The dominant components of the effective oils were 1-octen-3-ol (9%), n-nonanal, and linalool (both 7%) in C. tridentatum, geranial (43%), neral (29%), and β-myrcene (25%) in C. citratus, carvacrol (36% and 39%), γ-terpinene (24% and 40%), and p-cymene (14% and 7%) in O. vulgare and S. montana, respectively, and carvacrol (75% and 65%, respectively) in T. capitata and T. caespititius. The other essential oils obtained from Portuguese flora yielded weak or no activity. Five essential oils with nematicidal activity against PWN are reported for the first time.
Simulation of NMR Fermi Contact Shifts for Lithium Battery Materials: The Need for an Efficient Hybrid Functional Approach (2012)

In the context of the development of NMR Fermi contact shift calculations for assisting structural characterization of battery materials, we propose an accurate, efficient, and robust approach based on the use of an all electron method. The full-potential linearized augmented plane wave method, as implemented in the WIEN2k code, is coupled with the use of hybrid functionals for the evaluation of hyperfine field quantities. The WIEN2k code uses an autoadaptive basis set that is highly accurate for the determination of the hyperfine field. Furthermore the implementation of an onsite version for the Hartree–Fock exchange offers the possibility to use hybrid functional schemes at no additional computational cost. In this paper, NMR Fermi contact shifts for lithium are studied in different classes of paramagnetic materials that present an interest in the field of Li-ion batteries: olivine LiMPO4 (M = Mn, Fe, Co, and Ni), anti-NASICON type Li3M2(PO4)3 (M = Fe and V), and antifluorite-type Li6CoO4. Making use of the possibility to apply partial hybrid functionals either only on the magnetic atom or also on the anionic species, we evidence the role played by oxygen atoms on polarization mechanisms. Our method is quite general for an application on various types of materials. Furthermore, it is very competitive compared to the other methods recently proposed that are based either on a plane wave basis set with a PAW implementation or on an LCAO one with a full potential description.
Albumin induces upregulation of matrix metalloproteinase-9 in astrocytes via MAPK and reactive oxygen species-dependent pathways (2012)

These results link albumin (acting through ROS and the p38 MAPK) to the activation of MMP-9 in astrocytes. Numerous studies identify a role for MMP-9 in the mechanisms of compromise of the BBB, epileptogenesis, or synaptic remodeling after ischemia or traumatic brain injury. The increase in MMP-9 produced by albumin further implicates both astrocytes and albumin in the acute and long-term complications of acute CNS insults, including cerebral edema and epilepsy.
Dipotassium tetrakis(thiocyanato-κS)palladate(II)–(2,2′-bipyrimidine-κ2N1,N1′)bis(thiocyanato-κS)palladium(II) (1/2) (2012)

The asymmetric unit of the title compound, K(2)[Pd(NCS)(4)]·2[Pd(NCS)(2)(C(8)H(6)N(4))], contains two crystallographically independent half-mol-ecules of the anionic Pd(II) complex, two K(+) cations and two independent neutral Pd(II) complexes; an inversion centre is located at the centroid of each anionic complex. In the anionic complexes, each Pd(II) ion is four-coordinated in an almost regular square-planar environment by four S atoms from four SCN(-) anions, and the PdS(4) unit is exactly planar. In the neutral complexes, the Pd(II) ion has a slightly distorted square-planar coordination environment defined by two pyrimidine N atoms derived from a chelating 2,2'-bipyrimidine ligand and two mutually cis S atoms from two SCN(-) anions. Both 2,2'-bipyrimidine ligands are almost planar [dihedral angle between the rings = 3.98 (16) and 4.57 (17)°] and also chelate to a potassium ion from their other two N atoms. In the crystal, the K(+) ions inter-act with various S and N atoms of the ligands, forming a three-dimensional polymeric network, in which the shortest K⋯K contacts between the KN(7)S polyhedra are 4.4389 (17) and 4.4966 (18) Å. Intra- and inter-molecular C-H⋯S and C-H⋯N hydrogen bonds are also observed.
Environmental, Economic, and Energy Assessment of the Ultimate Analysis and Moisture Content of Municipal Solid Waste in a Parallel Co-combustion Process (2013)

Use of municipal solid waste (MSW) as fuel for electricity generation reduces landfill disposal and can mitigate air quality degradation associated with combustion of conventional fossil fuels. Co-combustion is a waste-to-energy technology that can use MSW and coal as co-fuels, offering potential energy recovery and reduced air emissions. This research discerns how MSW composition influences the heating value and air pollution for the co-combustion of coal with MSW using five MSW composition scenarios, four of which were derived by a reduction of plastics, organics, paper, or a combination thereof, as compared to the national average MSW composition. Numerous combustion products could be evaluated; this study focused on five high impact air combustion products: SO2, CO, CO2, NO, and NO2. The moisture content was varied from ∼10% (considered dry) to 40% (average MSW moisture). AspenPlus software was used for the deterministic simulation modeling of incineration (MSW only) and parallel co-firing (co-combustion of coal and MSW) to determine theoretical heating values and pollutant effluent concentrations. The United States Environmental Protection Agency (U.S. EPA) models WAR and WARM were used to determine the potential environmental impacts (PEIs) and greenhouse gas emission equivalencies, respectively, for each MSW scenario. For the WAR model, values for each impact category parameter can vary, but each parameter is weighed equally. Of the MSW scenarios studied, the national average held the highest heating value with 8519 MBtu/lb and the lowest occurred for the MSW scenario with recycled paper and composted organics, with 8251 MBtu/lb. Results show that SO2, CO, CO2, NO, and NO2 flue gas concentrations (and therefore PEIs) depend upon the composition and moisture of the MSW, in addition to the MSW/coal ratio. Approximate ranges for the WAR results (PEI/h) are 7410–7663 for NO, 4–8 for NO2, 18–105 for CO, 30–46 for CO2, and 89–2152 for SO2. WARM results show lower net CO2 emission equivalents to landfill MSW with reduced paper and organics, while combustion is preferred for MSW with paper reduction, organics reduction, and plastics reduction. The results for the national average MSW were independent of the disposal processing method. Reduction in pollutant concentrations did not yield overall cost savings for the electricity producer, as profit was reduced by ∼20–30%. There are savings associated with emission costs using MSW in lieu of coal: up to ∼3.3% for NO, ∼20–47% for NO2, and ∼95% for SO2. A hypothetical carbon dioxide tax was also imposed to realize the potential cost savings by reducing CO2 emissions. In summary, the measurable impact MSW composition and moisture had on pollutant concentration, heating value, and economic parameters was important.
NSLS-II Booster Acceptance Studies (2009)

The NSLS-II is a state of the art 3 GeV synchrotron light source being developed at BNL. The injection system will consist of a 200 MeV linac and a 3 GeV booster synchrotron. The injection system must supply 7.3 nC every minute to satisfy the top off requirements. A large booster acceptance is necessary to have a high booster injection efficiency and alleviate the requirements on the linac gun. We also anticipate transverse stacking of bunches in the booster to increase the amount of charge that can be delivered. We present studies of the anticipated booster stay clear and the ramifications for injection efficiency and transverse stacking.
Long-term expression of differentiated functions in hepatocytes cultured in three-dimensional collagen matrix (1998)

Hepatocytes entrapped in collagen gel and cultured in serum-free conditions survived longer than cells cultured on plastic (5 days vs. 3 weeks), showed fewer signs of early cell senescence (no increase in c-fos oncoprotein expression), and maintained the expression of differentiated hepatic metabolic functions over a longer period of time. Cells cultured in collagen gels retained their ability to respond to hormones. The insulin-stimulated glycogen synthesis rate remained fairly constant during 18 days in culture (between 5.4 +/- 0.37 and 9 +/- 2.7 nmol glucose/h/microg DNA). Collagen-cultured hepatocytes recovered glycogen stores to levels similar to those found in liver, or in hepatocytes isolated from fed rats. Urea synthesis from ammonia remained stable for more than 2 weeks (average value, 23 +/- 4 nmol urea/h/microg DNA). The rate of albumin synthesis in collagen-entrapped cells was maintained above the day-1 level during 18 days in culture. Cells showed high levels of glutathione (GSH) (1,278 +/- 152 pmol/microg DNA). Biotransformation activities CYP4501A1, CYP4502A2, CYP4502B1, and CYP4503A1 remained fairly stable in collagen-cultured hepatocytes. CYP4502E1 and CYP4502C11 decreased but were still measurable after 18 days. After 4 days in culture, GST activity returned to levels observed in isolated hepatocytes. In contrast with plastic cultures, cells responded to CYP450 inducers (methylcholanthrene for CYP4501A1, CYP4501A2, and glutathione-transferase, and ethanol for CYP4502E1) for more than 2 weeks. CYP4501A1, CYP4501A2, and glutathione-transferase A2 (GST A2) induction was preceded by an increase in specific mRNA, while the effects on CYP4502E1 seemed to be at a posttranslational level. Analysis of the expression of relevant hepatic genes by reverse Northern and semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) revealed that culturing hepatocytes in collagen gels results in a sustained higher expression of key liver transcription factor genes DBP, C/EBP-alpha and -beta, and HNF-1 and -4, as well as specific liver enzyme genes (phosphoenol pyryvate carboxykinase, and carbamoylphosphate-synthetase I).
Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis in a Japanese population (2006)

Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neurodegenerative disease that selectively affects motor neurons. Reactive oxygen species (ROS) are assumed to be involved in the pathogenesis of ALS. Metallothioneins (MTs) are self-protective, multifunctional proteins that scavenge ROS. In particular, metallothionein-III (MT-III) has a strong scavenging effect on hydroxyl radicals. MTs have been suggested to have important roles in the pathophysiology of ALS. Therefore we investigated single nucleotide polymorphisms (SNPs) of the MT-III and the metallothionein-IIA (MT-IIA) promoter region in 37 Japanese SALS cases and 206 sex-matched healthy controls using polymerase chain reaction (PCR)-direct sequencing or PCR-temporal temperature gradient gel electrophoresis (TTGE). We detected no SNPs of the MT-III gene in SALS cases and controls, and no detectable association between SALS phenotypes and a SNP of the MT-IIA promoter region. We conclude that gene polymorphisms of MT-IIA promoter region and MT-III gene are not associated with SALS phenotypes in a Japanese population.
Low infection rate and long durability of nontunneled silastic catheters. A safe and cost-effective alternative for long-term venous access. (1993)

Given the low infection rate and long durability of nontunneled silicone CVCs, these catheters could offer a cost-effective and safe alternative to surgically implantable tunneled catheters.
Diakoptic State Estimation Using Phasor Measurement Units (2008)

This paper presents a diakoptic-based distributed state estimation (SE) algorithm suitable for large-scale power systems. In the proposed approach the large-scale power system is divided into a certain number of subsystems by removing tie line measurements. Based on diakoptic theory, the SE problem is then partitioned into a number of subproblems which are solved for each subsystem using local computational resources. In subsequent steps, the intermediate subsystem SE solutions are sent to a central computer for completing the state estimation process by taking the tie line measurements into consideration. Phasor measurement units are used to make each subproblem solvable and to coordinate the voltage angles of each subsystem SE solution. Test results on the IEEE 14-bus test bed and IEEE 118-bus test bed are provided.
Pink Bollworm (Lepidoptera: Gelechiidae): Further Tests with (Z,Z)-Isomer of Gossyplure1 (1988)

Journal Article Pink Bollworm (Lepidoptera: Gelechiidae): Further Tests with (Z,Z)-Isomer of Gossyplure Get access Hollis M. Flint, Hollis M. Flint USDA-ARS, Western Cotton Research Laboratory, Phoenix, Arizona 85040 Search for other works by this author on: Oxford Academic PubMed Google Scholar Nancy J. Curtice, Nancy J. Curtice USDA-ARS, Western Cotton Research Laboratory, Phoenix, Arizona 85040 Search for other works by this author on: Oxford Academic PubMed Google Scholar Akira Yamamoto Akira Yamamoto USDA-ARS, Western Cotton Research Laboratory, Phoenix, Arizona 85040 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 81, Issue 2, 1 April 1988, Pages 679–683, https://doi.org/10.1093/jee/81.2.679 Published: 01 April 1988 Article history Received: 18 May 1987 Accepted: 05 November 1987 Published: 01 April 1988
Csf p-tau181/tau ratio as biomarker for TDP pathology in frontotemporal dementia (2014)

Our objective was to evaluate the CSF phospho-Tau181/total-Tau (p/t-Tau) ratio to distinguish between the two main forms of frontotemporal lobar degeneration (FTLD): FTLD with TDP-43 (FTLD-TDP) and FTLD with Tau inclusions (FTLD-Tau). CSF p/t-Tau ratio was examined in 79 FTLD patients with predictable neuropathology, i.e. Tau (affected by progressive supranuclear palsy or carriers of mutations within the MAPT gene) or TDP-43 (carriers of mutations within granulin, C9orf72, TARDBP genes or affected by FTD with motor neuron disease). FTLD patients were randomly grouped in a training cohort (n = 39) to assess the best CSF p/t-Tau cut-off score according to ROC analysis, and a validation cohort (n = 40) to evaluate accuracy values of the identified marker. Results showed that, in the training cohort, we found a significantly reduced CSF p/t-Tau ratio in FTLD-TDP relative to FTLD-Tau. ROC analysis for p/t-Tau ratio was 0.873 and cut-off score of 0.136 allowed to differentiate FTLD-TDP and FTLD-Tau with 81.8% sensitivity and 88.2% specificity, respectively. Analysis in the validation cohort showed CSF p/t-Tau ratio < 0.136 to distinguish FTLD-TDP from FTLD-Tau with 83.3% specificity and 63.6% sensitivity, respectively. The positive predictive value of detecting TDP neuropathology was 82.4%. In conclusion, a reduced CSF p/t-Tau ratio represents a viable biomarker to correctly identify TDP pathology in FTLD.
Development of the polishing method for a small tool using the slurry controlled by AC electric field (2018)

In polishing of aspherical lens shape or a large diameter reflecting mirror such as astronomical observatory, "a small tool" is used, which is smaller than the workpiece. Since small tools have low polishing efficiency, we propose a novel polishing method that leads to enhanced removal rate using AC electric field. In this paper, we report a result to polish a silicon wafer with the prototype small tool of this polishing method.
Design of Grain Boundary Phases in Silicon Nitride ‐ Silicon Carbide Nano‐Composites (2001)

This chapter contains sections titled: Introduction Experimental Results Conclusions