gebhart/patrepeval huggingface dataset:
Abstract 546: Selectively targeting CD47 with bispecific antibody to efficiently eliminate mesothelin-positive solid tumors (2019)

The CD47- signal regulatory protein α (SIRPα) axis, originally discovered as a mechanism of self-recognition, has emerged as a novel innate immune check-point employed by cancer cells to escape immune surveillance. Over-expression of CD47 on a plethora of hematologic and solid cancers has been shown to be associated with poor prognosis. CD47 blockade is thus considered as an attractive strategy to retune the host immune system toward eliminating cancer cells. Clinical efficacy has been achieved in patients with Non-Hodgkin lymphoma (NHL) treated with a combination of the anti-CD20 monoclonal antibody (mAb), rituximab, and the anti-CD47 mAb, Hu5F9-G4. However, in parallel, due to the ubiquitous expression of CD47 on healthy cells, toxicity is observed limiting exposure which impairs clinical development of anti-CD47 mAbs.To harness the tumoricidal potential and avoid the liabilities of CD47 blockade, we have developed bispecific antibodies (bsAbs), co-targeting CD47 and a tumor associated antigen (TAA), for selective blockade of CD47 on malignant cells. Mesothelin (MSLN) has been selected as one of these TAAs as it is over-expressed on multiple types of solid tumors. An anti-CD47xMSLN bsAb with a fully functional IgG1 Fc domain has been generated and tested for efficacy and safety in vitro and in vivo using cell-based assays and animal models.With a panel of human MSLN+ target cells, the bsAb kills more efficiently through Ab-dependent cellular phagocytosis (ADCP) and cell-mediated cytotoxicity (ADCC) as compared to the anti-MSLN mAb, amatuximab. Efficacy of the bsAb was minimally affected by soluble MSLN as compared to amatuximab. Mechanistic studies demonstrated that the increased ADCP and ADCC were due to co-engagement-mediated blockade of both target proteins. In vivo using xenograft models, whereas amatuximab was unable, the bsAb inhibited tumor growth of OVCAR3 and MSLN-transfected HepG2 cell lines. Phenotypic analysis showed that treatment with the bsAb induced the accumulation of myeloid cells with increased F4/80 expression in the tumor microenvironment. Importantly, the bsAb was well-tolerated in an exploratory four-week repeated dose study at the highest dose tested (10 mg/kg) in cynomolgus monkeys.Conclusion: Selective CD47 targeting on tumor cells with an anti-CD47xMSLN bsAb showed efficient killing of MSLN+ tumor cells in vitro and in vivo. A study in non-human primates administered weekly a therapeutically relevant dose over 28 days was well tolerated demonstrating no adverse hematological profiles.Citation Format: Limin Shang, Vanessa Buatois, Eric Hatterer, Xavier Chauchet, Hasnaà Haddouk, Stefano Majocchi, Krzysztof Masternak, Marie H. Kosco-Vilbois, Nicolas Fischer, Walter G. Ferlin. Selectively targeting CD47 with bispecific antibody to efficiently eliminate mesothelin-positive solid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 546.
Frequency-Reconfigurable Antenna Using Metasurface (2013)

A frequency-reconfigurable antenna designed using metasurface (MS) to operate at around 5 GHz is proposed and studied. The frequency-reconfigurable metasurfaced (FRMS) antenna is composed of a simple circular patch antenna and a circular MS with the same diameter of 40 mm (0.67 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$\lambda $</tex></formula> ) and implemented using planar technology. The MS is placed directly atop the patch antenna, making the FRMS antenna very compact and low profile with a thickness of only 3.048 mm (0.05 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\lambda $</tex></formula> ). The MS consists of rectangular-loop unit cells placed periodically in the vertical and horizontal directions. Simulation results show that the operating frequency of the antenna can be tuned by physically rotating the MS around the center with respect to the patch antenna. The MS placed atop the patch antenna behaves like a dielectric substrate and rotating the MS changes the equivalent relative permittivity of the substrate and hence the operating frequency of the FRMS antenna. Measured results show that the antenna has a tuning range from 4.76 to 5.51 GHz, a fractional tuning range of 14.6%, radiation efficiency and a realized peak gain of more than 80% and 5 dBi, respectively, across the tuning range.
Chest Tube Selection in Cardiac and Thoracic Surgery: A Survey of Chest Tube-Related Complications and Their Management (2009)

Results of this survey highlight the frequent problems with clogging with current postsurgical chest drainage systems and suggest the need for innovative solutions to avoid clogging complications and overcome clinician concern and patient pain.
ChemInform Abstract: PHOTOCYCLOADDITIONSRK. VON ARYLAZIRINEN MIT HETERO‐MEHRFACHBINDUNGEN (1973)

Abstract 2,3‐Diphenyl‐azirin (I) reagiert bei der Photolyse z.B. in Benzol über die Zwischenstufe (II).
Functional Micropatterned Surfaces by Combination of Plasma Polymerization and Lift‐Off Processes (2005)

Abstract Summary: In this study, microstructured surfaces are produced by a spatial arrangement of different functional domains by a combination of plasma polymerization and photolithography. Two different kinds of protein and cell adhesive patterns have been alternated with non‐fouling areas. Non‐fouling patterns are made of poly(ethylene oxide) (PEO)‐like polymers obtained by pulsed plasma polymerization of diethylene glycol dimethyl ether, which leads to coatings with a high concentration of ethylene oxide groups (&gt;70%). Fouling surfaces are composed of PEO coatings with a low concentration of ethylene oxide groups (≈40%) and films containing amino groups (from allylamine monomer) obtained by plasma polymerization. High pattern fidelity is demonstrated by ellispometry measurements, whereas XPS and ToF‐SIMS analyses have been used to characterize the surfaces. Experiments with a model protein (bovine serum albumin) and cells (L929 mouse fibroblasts) on patterned surfaces show that proteins and cells only adhere on the patterns, whereas the background stays uncovered. Optical image showing the selective proliferation of L929 mouse fibroblast cells after culture on a pulsed PEO‐like/PAL micropatterned surface. magnified image Optical image showing the selective proliferation of L929 mouse fibroblast cells after culture on a pulsed PEO‐like/PAL micropatterned surface.
The Genome Sequence of Mycoplasma mycoides subsp. mycoides SC Type Strain PG1T, the Causative Agent of Contagious Bovine Pleuropneumonia (CBPP) (2004)

Mycoplasma mycoides subsp. mycoidesSC (MmymySC)is the etiological agent of contagious bovine pleuropneumonia (CBPP), a highly contagious respiratory disease in cattle. The genome of Mmymy SC type strain PG1(T) has been sequenced to map all the genes and to facilitate further studies regarding the cell function of the organism and CBPP. The genome is characterized by a single circular chromosome of 1211703 bp with the lowest G+C content (24 mole%)and the highest density of insertion sequences (13% of the genome size)of all sequenced bacterial genomes. The genome contains 985 putative genes, of which 72 are part of insertion sequences and encode transposases. Anomalies in the GC-skew pattern and the presence of large repetitive sequences indicate a high genomic plasticity. A variety of potential virulence factors was identified, including genes encoding putative variable surface proteins and enzymes and transport proteins responsible for the production of hydrogen peroxide and the capsule, which is believed to have toxic effects on the animal.
Plasmid-Mediated Resistance to Expanded-Spectrum Cephalosporins among Enterobacter aerogenes Strains (1998)

Resistance to expanded-spectrum cephalosporins commonly develops in Enterobacter aerogenes during therapy due to selection of mutants producing high levels of the chromosomal Bush group 1 beta-lactamase. Recently, resistant strains producing plasmid-mediated extended-spectrum beta-lactamases (ESBLs) have been isolated as well. A study was designed to investigate ESBL production among 31 clinical isolates of E. aerogenes from Richmond, Va., with decreased susceptibility to expanded-spectrum cephalosporins and a positive double-disk potentiation test. Antibiotic susceptibility was determined by standard disk diffusion and agar dilution procedures. Beta-lactamases were investigated by an isoelectric focusing overlay technique which simultaneously determined isoelectric points (pIs) and substrate or inhibitor profiles. Decreased susceptibility to cefotaxime, ceftazidime, and aztreonam (MIC range, 1 to 64 microg/ml) was detected and associated with resistance to gentamicin and trimethoprim-sulfamethoxazole. All strains produced an inducible Bush group 1 beta-lactamase (pI 83). Twenty-nine of the 31 isolates also produced an enzyme similar to SHV-4 (pI 7.8), while 1 isolate each produced an enzyme similar to SHV-3 (pI 6.9) and to SHV-5 (pI 8.2). The three different SHV-derived ESBLs were transferred by transconjugation to Escherichia coli C600N and amplified by PCR. Plasmid profiles of the clinical isolates showed a variety of different large plasmids. Because of the linkage of resistance to aminoglycosides and trimethoprim-sulfamethoxazole with ESBL production, it is possible that the usage of these drugs was responsible for selecting plasmid-mediated resistance to extended-spectrum cephalosporins in E. aerogenes. Furthermore, it is important that strains such as these be recognized, because they can be responsible for institutional spread of resistance genes.
Enhanced conversion efficiency in perovskite solar cells by effectively utilizing near infrared light (2016)

Up-conversion β-NaYF4:Yb(3+),Tm(3+)/NaYF4 core-shell nanoparticles (NYF NPs) with a high luminous intensity in the visible light region were synthesized by a hydrothermal reaction process. Photocurrent densities of the mesoscopic perovskite solar cells fabricated by incorporating up-conversion NYF NPs into the electron transporting layer are effectively enhanced. The effects of the thicknesses of the electron transporting layer and the weight ratio of up-conversion NYF NPs/TiO2 on the power conversion efficiency (PCE) of the as-fabricated devices were also investigated. The results indicate that the PCE of the optimized device achieves 16.9%, which is 20% higher than that of the device without introducing NYF NPs, and the steady-state PCE of the as-fabricated devices is close to its transient-state PCE. The up-conversion effect of NYF NPs is conducive to higher device performance rather than the nanoparticles as scattering centers to increase possible light absorption of the perovskite film or the electronic effect of the NaYF4 shell surface. These results can be further confirmed by finite-difference time-domain simulation. Photoluminescence results suggest that the multiphonon-assistance can accelerate the nonradiative recombination process at a lower temperature. Incorporating NYF NPs into the electron transporting layer opens a new approach to a promising family of electron transporting materials for mesoscopic perovskite solar cells.
ChemInform Abstract: NONCLASSICAL THIENO(3,4‐C)THIADIAZOLE (1980)

Abstract 3,4‐Bis‐chlormethyl‐l ,2,5‐thiadiazol (I) cyclisiert zum Sulfid (II), das nach Oxidation zum Sulfoxid (III) mit Acetanhydrid zum instabilen Thienothiadiazol (IV) dehydratisiert wird.
Detection of Donor-Derived Microparticles in the Peripheral Blood of a Hand Transplant Recipient During Rejection (2017)

These findings demonstrate the ability to detect donor specific MPs through staining of graft cell-specific HLA and promote further investigation into the potential utility of flow cytometry for donor-derived MPs as a noninvasive tool to assess rejection in solid organ transplantation patients.
High-Performance Buried-Gate Surrounding Gate Transistor for Future Three-Dimensional Devices (2004)

We propose the buried-gate surrounding gate transistor (BG-SGT) as a high-performance transistor. The occupied area of BG-SGT can be shrunk to 50% of that of the planar transistor. Moreover, decreasing the body pillar size leads to a steep subthreshold slope. Because of these features, BG-SGT is extremely attractive for future three-dimensional devices.
Film Cooling Predictions Along the Tip and Platform of a Turbine Blade (2003)

Turbine airfoils are exposed to the hottest temperatures in the gas turbine with temperatures typically exceeding the melting point of the blade material. Cooling methods investigated in this computational study included parasitic cooling flow losses, which are inherent to engines, and microcircuit channels. Parasitic losses included dirt purge holes, located along the blade tip, and platform leakage flow, which result from gaps between various turbine components. Microcircuits are a novel cooling technique involving small air passages placed near the airfoil surface to enhance internal cooling. This study evaluated the benefit of external film-cooling flow exhausted from strategically placed microcircuits. Along the blade tip, predictions showed mid-chord cooling was independent of the blowing from microcircuit exits. The formation of a pressure side vortex was found to develop for most microcircuit film-cooling cases. Significant leading edge cooling was obtained from coolant exiting from dirt purge holes with a small tip gap while little cooling was seen with a large tip gap. Along the blade platform, the migration of coolant from the front leakage was shown to cool a considerable part of the platform. Several hot spots were predicted along the platform, which were circumvented through the placement of microcircuit channels. Ingestion of hot mainstream gas was predicted along the aft portion of the gutter and agreed with distress exhibited by actual gas turbine engines.
Mucin Is Produced by Clara Cells in the Proximal Airways of Antigen-Challenged Mice (2004)

Airway mucus hypersecretion is a prominent feature of many obstructive lung diseases. We thus determined the ontogeny and exocytic phenotype of mouse airway mucous cells. In naive mice, ciliated (approximately 40%) and nonciliated (approximately 60%) epithelial cells line the airways, and > 95% of the nonciliated cells are Clara cells that contain Clara cell secretory protein (CCSP). Mucous cells comprise < 5% of the nonciliated cells. After sensitization and a single aerosol antigen challenge, alcian blue-periodic acid Schiff's positive mucous cell numbers increase dramatically, appearing 6 h after challenge (21% of nonciliated/nonbasal cells), peaking from Days 1-7 (99%), and persisting at Day 28 (65%). Throughout the induction and resolution of mucous metaplasia, ciliated and Clara cell numbers identified immunohistochemically change only slightly. Intracellular mucin content peaks at Day 7, and mucin expression is limited specifically to a Clara cell subset in airway generations 2-4 that continue to express CCSP. Functionally, Clara cells are secretory cells that express the regulated exocytic marker Rab3D and, in antigen-challenged mice, rapidly secrete mucin in response to inhaled ATP in a dose-dependent manner. Thus, Clara cells show great plasticity in structure and secretory products, yet have molecular and functional continuity in their identity as specialized apical secretory cells.
Electrical resistivity tomography (ERT) measurements during water flow in a date palm stem segment (2023)

Commercial cultivation of date palms has high economic significance, particularly in arid and hyper-arid regions. Achieving commercially viable yield of dates amid water scarcity and enforced restrictions on water use requires optimising the amount and timing of irrigation. To that end, better understanding of the temporal dynamics of the water use of date palm is of great importance. Traditionally, this can be achieved through sap flow estimates obtained using heat dissipation probes. However, such measurements lack the ability to provide information on the spatial distribution of sap flow, which is important considering that date palms transport water in the entire stem cross-section. The aim of this study is to evaluate whether electrical resistivity tomography measurements have the potential to provide information on the spatial variability of flow in date palm stems. For this, flow was induced through a stem segment that was obtained from a felled date palm tree. ERT measurements were continuously obtained throughout a cycle of flow and no-flow periods. The results showed that the mean bulk electrical conductivity varied strongly due to changes in the flow conditions. In addition, it was found that the electrical conductivity of the outflow was much higher than that of the inflow, which indicates the release of stored salt from the stem segment. Analysis of the spatial distribution of the electrical conductivity suggested that flow mainly occurred in a limited part of the cross-sectional area of the stem. Overall, it was concluded that the ERT is a promising tool to investigate the spatial variability of water flow in date palm stems.
Inorganic Fibres and Composite Materials: A Survey of Recent Developments (1984)

Inorganic fibres, their manufacture and properties: metal fibres - iire drawing techniques. Melt forming techniques. Carbon fibres - manufacture processes. Post-treatments of carbon fibres. Boron fibres - use of other core materials. Improvements in the CVD process and related apparatus. Polycrystalline refractory oxide fibres - manufacture processes. Composition, properties and applications. Polycrystalline refractory carbide, nitride and boride fibres - chemical vapor deposition. Other fibres - review. New types of fibres developed since 1970. Monocrystalline fibres: growth techniques - growth from the vapor phase. Growth from solutions. Growth from gels. Other techniques. Inorganic fibres composite materials: metal matrix composites - the metal fibre-metal matrix systems. The carbon-, boron-, carbide-, boride-fibre-metal matrix system. Ceramic or glass matrix composites - metal-ceramic systems. Ceramic-ceramic systems. General methods for the manufacture of composite materials - methods based on the combination of preformed fibres with matrix material. Methods involving the in situ generation of fibres. List of cited patents. List of patentees. Subject index.
A new method of partial deafness treatment. (2003)

The results demonstrate a substantial improvement in speech discrimination and communication skills when electric stimulation on one side was combined with acoustic stimulation on both sides.
ChemInform Abstract: Synthesis and Crystal Structure of Mn2 (C2H5NH2) 2Sb2S5 Exhibiting a Reversible Phase Transition. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bi-weekly paclitaxel and capecitabine as a second- or third-line treatment for advanced breast cancer: a pilot study. (2013)

Bi-weekly dosing of paclitaxel and capecitabine seems to yield promising responses in advanced breast cancer, with an acceptable adverse-event profile.
Rapid Thermal Processing and the Control of Oxygen Precipitation Behaviour in Silicon Wafers (2008)

The use of Rapid Thermal Processing to install lattice vacancy profiles into silicon wafers for the purpose of forming a template for the nucleation and ideal control of oxygen precipitation has become an important materials engineering tool for the microelectronics industry. This paper reviews the principles of the technique and the precise materials/defect engineering that it engenders. It furthermore discusses what has been learned regarding the elusive properties of the intrinsic point defects in silicon through studies of the distributions of vacancies created by use of the technique. Also discussed are recent discoveries about the critical role of the other intrinsic point defect, the self-interstitial and the development of oxygen precipitates and their distributions post-nucleation and the critical importance of what has become to be called the “ninja transformation” in the switching-on of gettering efficiency of oxygen precipitate systems.
Design of a Framework for Automated Service Mashup Creation and Execution Based on Semantic Reasoning (2010)

Instead of building self-contained silos, applications are being broken down in independent structures able to offer a scoped service using open communication standards and encoding. Nowadays there is no automatic environment for the construction of new mashups from these reusable services. At the same time the designer of the mashup needs to establish the actual locations for deployment of the different components. This paper introduces the development of a framework focusing on the dynamic creation and execution of service mashups. By enriching the available building blocks with semantic descriptions, new service mashups are automatically composed through the use of planning algorithms. The composed mashups are automatically deployed on the available resources making optimal use of bandwidth, storage and computing power of the network and server elements. The system is extended with dynamic recovery from resource and network failures. This enrichment of business components and services with semantics, reasoning, and distributed deployment is demonstrated by means of an e-shop use case.
Single-Photon Detection in Near-Infrared Region Based on Frequency Upconversion in MgO-Doped Periodically-Poled Lithium Niobate Waveguide (2011)

MgO-doped periodically-poled LiNbO3 waveguide is used to up-convert photons at 1.535-1.568 µm to those at 598-603 nm, which can be detected by avalanche photodetector at single-photon counting level. Conversion efficiencies up to 45% are achieved.
Two-port tunable interdigital capacitors fabricated on low-loss MBE-grown Ba0.29Sr0.71TiO3 (2016)

This paper describes the fabrication, measurement, and modelling of radio-frequency (RF), tunable interdigital capacitors (IDC). The devices utilize electric-field tunable Ba <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> Sr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(1-x)</sub> TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (BST) thin films grown by hybrid molecular beam epitaxy (MBE) on LaAlO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (LAO) substrates, a first growth of its kind. A high-quality interface was achieved by hot-sputtering epitaxial platinum. S/L-band IDCs demonstrate high quality factors (200) combined with 47% tunability. The devices demonstrate a commutation quality factor averaging 6,000 across the L band. A phase shifter unit cell was simulated and implemented using the IDC equivalent circuit parameters.
“Death Diamond” Tracing on Thromboelastography as a Marker of Poor Survival After Trauma (2021)

The DD is highly predictive of trauma-associated mortality. This multicenter study highlights that serial DDs may represent a possible biomarker of futility.