gebhart/patrepeval huggingface dataset:
Local proteolytic activation after pulmonary trauma is not prevented by high dose steroids (1989)

Local trauma to the lungs induces a temporary permeability disturbance with reduction in the osmotic reflection coefficient of a sheep lung lymph model. Proteolytic enzymes may be involved in this microvascular injury. In the present study, we tested the hypothesis that pretreatment with methylprednisolone prevents activation of proteolytic systems after pulmonary trauma and that these systems are of etiological importance in the development of the pulmonary lesion. Central markers of proteolytic cascade systems were monitored in sheep subjected to local trauma to the lungs (lung lymph fistula preparation) with (n = 7) or without (n = 7) methylprednisolone (30 mg/kg) pretreatment. In control animals, reduced levels of prothrombin, antithrombin, kallikrein inhibitors, antiplasmin, and increased level of plasminogen activator inhibitor (PAI) indicated systemic activation of the coagulation, kallikrein-kinin, and fibrinolytic systems. These changes, except for PAI, were more pronounced in lung lymph. High levels of thromboxane A2 and 6-keto prostaglandin F1 alpha were found in lymph. In steroid-pretreated animals, the prostanoid response was attenuated, but all other variables were similar to control animals; thus, steroids did not prevent either local or systemic proteolytic enzyme activation caused by local trauma to the lung. The etiological role of this activation in the development of lung lesion has not yet been evaluated.
Formation of nanoscale ferromagnetic MnAs crystallites in low-temperature grown GaAs (1997)

We report the formation of nanosize ferromagnetic MnAs crystallites imbedded in low-temperature grown GaAs using Mn+ ion implantation and subsequent annealing. The structural and magnetic properties of the crystallites have been characterized by transmission electron microscopy, electron beam induced x-ray fluorescence, and superconducting quantum interference device magnetometry. After an optimized thermal annealing at 750 °C, MnAs crystallites of 50 nm in size are formed. These nanomagnets show room temperature ferromagnetism.
Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis (2014)

The immune response after brain injury is highly complex and involves both local and systemic events at the cellular and molecular level. It is associated to a dramatic over-activation of enzyme systems, the expression of proinflammatory genes and the activation/recruitment of immune cells. The complement system represents a powerful component of the innate immunity and is highly involved in the inflammatory response. Complement components are synthesized predominantly by the liver and circulate in the bloodstream primed for activation. Moreover, brain cells can produce complement proteins and receptors. After acute brain injury, the rapid and uncontrolled activation of the complement leads to massive release of inflammatory anaphylatoxins, recruitment of cells to the injury site, phagocytosis and induction of blood brain barrier (BBB) damage. Brain endothelial cells are particularly susceptible to complement-mediated effects, since they are exposed to both circulating and locally synthesized complement proteins. Conversely, during neurodegenerative disorders, complement factors play distinct roles depending on the stage and degree of neuropathology. In addition to the deleterious role of the complement, increasing evidence suggest that it may also play a role in normal nervous system development (wiring the brain) and adulthood (either maintaining brain homeostasis or supporting regeneration after brain injury). This article represents a compendium of the current knowledge on the complement role in the brain, prompting a novel view that complement activation can result in either protective or detrimental effects in brain conditions that depend exquisitely on the nature, the timing and the degree of the stimuli that induce its activation. A deeper understanding of the acute, subacute and chronic consequences of complement activation is needed and may lead to new therapeutic strategies, including the ability of targeting selective step in the complement cascade.
Isomerization of cycloheptane, cyclooctane, and cyclodecane catalyzed by sulfated zirconia—comparison with open-chain alkanes (2003)

The skeletal isomerization of cycloalkanes with the number of carbons greater than six, cycloheptane, cyclooctane, cyclodecane, and cyclododecane, was performed over sulfated zirconia in liquid phase at 50 °C. A main product of methylcyclohexane was formed from cycloheptane via a protonated cyclopropane intermediate, protonated [4.1.0]bicycloheptane, together with small amounts of trans-1,2-dimethylcyclopentane, cis- and trans-1,3-dimethylcyclopentanes, 1,1-dimethylcyclopentane, and ethylcyclopentane. A major product from cyclooctane was ethylcyclohexane via a protonated cyclobutane intermediate, protonated [4.2.0]bicyclooctane, followed by cis-1,3-dimethylcyclohexane in addition to small amounts of trans-1,2-, -1,3-, -1,4-dimethylcyclohexanes, 1,1-dimethylcyclohexane, and methylcycloheptane. The detailed reaction-paths for cycloheptane and cyclooctane were shown after additional examinations in reactions of methylcyclohexane, ethylcyclopentane, ethylcyclohexane, and 1,2-dimethylcyclohexane. Cyclodecane was dehydrogenated into cis- or trans-decaline with the evolution of a dihydrogen. Cyclododecane was converted into lots of products, more than 30 species.
The selection recognition agent (1997)

We present the Selection Recognition Agent (SRA). a personal computer application which recognizes meaningful words and phrasesin text, and enables useful operations on them. The SRA includes six recognition modules for geographic names, dates, email addresses, phone numbers, Usenet newsgroup name components, and URLS, as well as a module that enables useful operations on text in general. The SRA runs on Microsoft Windows 95 and Windows NT* and is currently available free from Intel's home page (http://www.intel.com).
Cloning and Characterization of a Secreted Frizzled-Related Protein that is Expressed by the Retinal Pigment Epithelium (1999)

The Wnt/frizzled cell signaling pathway has been implicated in the determination of polarity in a number of systems, including the Drosophila retina. The vertebrate retina develops from an undifferentiated neuroepithelium into an organized and laminated structure that demonstrates a high degree of polarity at both the tissue and cellular levels. In the process of searching for molecules that are preferentially expressed by the vertebrate retinal pigment epithelium (RPE), we identified secreted frizzled-related protein 5 (SFRP5), a member of the SFRP family that appears to act by modulating Wnt signal transduction. SFRP5 is highly expressed by RPE cells, and is also expressed in the pancreas. Within the retina, the related molecule SFRP2 is expressed specifically by cells of the inner nuclear layer. Thus, photoreceptors are likely to be bathed by two opposing gradients of SFRP molecules. Consistent with SFRP5 's postulated role in modulating Wnt signaling in the retina, it inhibits the ability of Xwnt-8 mRNA to induce axis duplication in Xenopus embryos. The human SFRP5 gene consists of three coding exons and it maps to chromosome 10q24.1; human SFRP2 maps to 4q31.3. Based on the biology and complementary expression patterns of SFRP2 and SFRP5, we suggest that they may be involved in determining the polarity of photoreceptor, and perhaps other, cells in the retina.
Improved double immunoenzyme labelling using alkaline phosphatase and horseradish peroxidase (1982)

Alkaline phosphatase and peroxidase complexes were applied to tissue sections simultaneously to label two antigens. An azo-coupling method was used to demonstrate the alkaline phosphatase activity. The final result gave clear contrast between the two antigens and allowed the use of haematoxylin as the nuclear counterstain.
Nash Welfare and Round Robin Share. (2016)

We study a problem in which a decision must be made on multiple social issues simultaneously. We define three new notions of fairness based on guarantees provided by naive round-robin decision-making mechanisms -- one that can only be achieved by exploiting randomized mechanisms, and two weaker notions that can be achieved by deterministic mechanisms. Finally, we examine whether the Nash Bargaining Solution satisfies our fairness notions.
Is the Drought Over for Pharming? (2008)

Companies are plowing ahead, making drugs and other compounds in plants, despite technological, economic, and social issues.
Biofilm formation is not a prerequisite for production of the antibacterial compound tropodithietic acid inPhaeobacter inhibensDSM17395 (2014)

This study contributes to the understanding of TDA production in P. inhibens, which has great potential as a probiotic in marine larviculture.
Characterization of wine neutral oligosaccharides by Hydrophilic Interaction Liquid Chromatography coupled to ESI-MS (2015)

Characterization of wine neutral oligosaccharides by Hydrophilic Interaction Liquid Chromatography coupled to ESI-MS. In vino analytica Scientia
Expression of VCAM-1 in Lymphocytes during the Process of Apoptosis (1998)

The administration of corticosteroids induced apoptosis of thymocytes in vivo. Among various adhesion molecules examined, vascular cell adhesion molecule-1 (VCAM-1, CD106) was shown to be strongly expressed in these apoptotic cells. Flow cytometric analysis also showed the expression of VCAM-1 in apoptotic thymocytes. An RT-PCR study demonstrated the expression of VCAM-1 mRNA in thymocytes. Splenic lymphocytes and other lymphoid cell lines also expressed VCAM-1 during the process of apoptosis. VCAM-1 mRNA expression was also observed in RT-PCR performed on these cell lines.
The data acquisition system for the Anglo-Australian Observatory 2-degree field project (1992)

The Anglo-Australian Observatory (AAO) is building a system that will provide a two-degree field of view at prime focus. A robot positioner will be used to locate up to 400 optical fibers at pre-determined positions in this field. While observations are being made using one set of 400 fibers, the robot will be positioning a second set of fibers in a background field that can be moved in to replace the first when the telescope is moved to a new position. The fibers feed two spectrographs each with a 1024 square CCD detector. The software system being produced to control this involves Vaxes for overall control and data recording, UNIX workstations for fiber configuration calculations and on-line data reduction, and VME systems running VxWorks for real-time control of critical parts such as the positioner robot. The system has to be able to interact with the observatory's present data acquisition systems, which use the ADAM system. As yet, the real-time parts of ADAM have not been ported to Unix, and so we are having to produce a smaller-scale system that is similar but inherently distributed (which ADAM is not). We are using this system as a testbed for ideas that we hope may eventually influence an ADAM II system. The system we are producing is based on a message system that is designed to be able to handle inter-process and inter-processor messages of any length, efficiently, and without ever requiring a task to block (i.e., be unresponsive to 'cancel' messages, enquiry messages), other than when deliberately waiting for external input - all of which will be through such messages. The essential requirement is that a message 'send' operation should never be able to block. The messages will be hierarchical, self-defining, machine-independent data structures. This allows us to provide very simple monitoring of messages for diagnostic purposes, and allows general purpose interface programs to be written without needing to share precise byte by byte message format definitions. Programs in this system have interfaces defined simply in terms of named actions and their parameters. Real-time control programs are required to be able to handle a number of such actions concurrently; data reduction programs will normally only need to handle one action at a time ('process an image', 'display a spectrum', etc).
Visible light communication using a conventional image sensor (2015)

This paper proposes a novel Visible Light Communication (VLC) method. There are currently two types of VLC methods, classified by receiving device: the photosensor-based method and the image sensor-based method, each of which has its own drawbacks. Photosensor-based methods require a dedicated high-speed photosensor and a decoder IC that are not installed in commercial smartphones; on the other hand the communication speeds of image sensor-based methods are very slow. Our VLC method consists of a new image sensor-based receiving method, Line Scan Sampling (LSS), which comprises a sampling procedure that is a thousand times faster than conventional image frame-based sampling, combined with LSS-specific modulation schemes. It realizes lighting communication for smartphone receivers at communication speeds that exceed 1 kbps. Our technology is expected to be applicable to various fields, such as indoor positioning systems, signage translation, distribution of coupons, and vehicle communications. In this paper, we describe the principle of the receiving method, suitable modulation schemes, and the experimentally-measured performance of the system.
Arthroscopic subacromial decompression with and without tenotomy of the long head of biceps tendon for treatment of impingement syndrome (2010)

Objective To compare the effects of arthroseopic subacromial decompression with and without tenotomy of the long head of biceps tendon(LHBT) for the treatment of impingement syndrome. Methods Between February 2006 and May 2008, 42 patients (42 shoulders) were operated on by the same surgeons for impingement syndrome in our department. Of them, 24 (Group A) were managed with only arthroscopic subacromial decompression and 18 (Group B) with arthroscopic subacromial decompression plus tenotomy of LHBT. Their mean age was 65 years (range, 50 to 75 years) and the average follow-up was 15 months (range, 12 to 24 months). There was no significant difference between the 2 groups in age, gender, pain, function, and follow-up. All patients had severe pain, weakness and limited range of motion preoper-atively. Constant scores were used for postoperative assessments. Results In Group A, the average Constant score improved from preoperative 38. 3 points (range, 20 to 54 points) to postoperative 67. 3 points (range, 47 to 89 points), and 21 patients (87.5%) were satisfied with the effect. In Group B, the average Constant score improved from preoperative 38.1 points (range, 18 to 54 points) to postoperative 68.6 points (range, 47 to 88 points), and 16 patients (88.9%) were satisfied. No statistical significance (P>0.05) was found between the 2 groups. Although patients receiving LHBT tenotomy had a significantly greater pain relief in a short term postoperatively than those receiving only decompression (P 0.05). Conclusions Arthroscopic suhacromial decompression can significantly improve impingement syndrome. Additional LHBT tenotomy may have a greater effect of pain relief than arthroscopic subacromial decompression alone in a short term.

Key words: 
Shoulder impingement syndrome; Decompression, surgical; Muscle, skeletal; Arthroscopy
Membrane Estrogen Receptors Stimulate Intracellular Calcium Release and Progesterone Synthesis in Hypothalamic Astrocytes (2010)

In hypothalamic astrocytes obtained from adult female rats, estradiol rapidly increased free cytoplasmic calcium concentrations ([Ca(2+)](i)) that facilitate progesterone synthesis. The present study demonstrated that estradiol (1 nm) significantly and maximally stimulated progesterone synthesis within 5 min, supporting a rapid, nongenomic mechanism. The group I metabotropic glutamate receptor (mGluR1a) antagonist LY 367385 [(S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid] attenuated both the estradiol-induced [Ca(2+)](i) release and progesterone synthesis. To investigate membrane-associated estrogen receptors (mERs), agonists for ERα, ERβ, STX-activated protein, and GPR30 were compared. The selective ERα agonist propylpyrazole triole (PPT) and STX most closely mimicked the estradiol-induced [Ca(2+)](i) responses, where PPT was more potent but less efficacious than STX. Only high doses (100 nm) of selective ERβ agonist diarylpropionitrile (DPN) and GPR30 agonist G-1 induced estradiol-like [Ca(2+)](i) responses. With the exception of DPN (even at 100 nm), all agonists stimulated progesterone synthesis. The PPT- and STX-induced [Ca(2+)](i) release and progesterone synthesis were blocked by LY 367385. While the G-1-stimulated [Ca(2+)](i) release was blocked by LY 367385, progesterone synthesis was not. Since GPR30 was detected intracellularly but not in the membrane, we interpreted these results to suggest that G-1 could activate mGluR1a on the membrane and GPR30 on the smooth endoplasmic reticulum to release intracellular calcium. Although STX and G-1 maximally stimulated [Ca(2+)](i) release in astrocytes from estrogen receptor-α knock-out (ERKO) mice, estradiol in vivo did not stimulate progesterone synthesis in the ERKO mice. Together, these results indicate that mERα is mainly responsible for the rapid, membrane-initiated estradiol-signaling that leads to progesterone synthesis in hypothalamic astrocytes.
Novel modulation method of a three-level isolated full-bridge LLC resonant DC-DC converter for wide-output voltage application (2012)

This paper presents a three-level isolated LLC resonant converter using a novel modulation strategy for wide-voltage range operation. With the proposed modulation strategy, the DC gain of the converter can be changed between V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> and ½V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> . The output voltage can be then adjusted within the two resulting voltage ranges by either varying the switching frequency of the converter or utilizing a post regulator. In the last option, the three-level converter works as an electronic transformer with variable turns ratio. Therefore, the converter can be designed to operate with a narrow operation condition maintaining high efficiency despite of wide-voltage range variations. A hybrid gate driver which simplifies the implementation of the proposed modulation method is also presented. The novel modulation method is analysed and verified on a 20kW, LLC three-level resonant prototype operating at 110 kHz.
An ADPLL with a MASH 1-1-1 &#x0394;&#x03A3; Time-digital converter (2014)

An all digital phase-locked loop with a frequency range of 2.35 ~ 2.55 GHz is presented. A MASH 1-1-1 ΔΣ time-digital converter is used to quantize phase errors. High resolution and third-order noise-shaping are achieved simultaneously. A digitally controlled oscillator with three-stage tuning bank is used to realize wide frequency range and high frequency resolution. A prototype integrated in 130nm CMOS process exhibits a phase noise of -122 dBc/Hz @1MHz offset at a frequency of 2.48 GHz and a power dissipation of 11 mW under a supply of 1.2 V. The core occupied 0.49 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> of area.
Abstract 216: Cyclophilin A Regulates Hemostasis by Affecting Multiple Platelet Functions (2012)

Background: Cyclophilin A (CyPA) is ubiquitously expressed and regulates multiple cellular functions including protein folding, intracellular trafficking and signal transduction. Extracellular CyPA is an inflammatory mediator that contributes to atherosclerosis, aortic aneurysms, vascular remodeling and myocardial ischemic reperfusion injury. Recent studies have shown that interactions among platelets, endothelial cells and leukocytes play important roles in inflammation. However, the role of CyPA in platelet function and thrombosis remains unclear. We hypothesized that CyPA is involved in platelet activation, resulting in an impact on hemostasis and arterial thrombosis. Methods: Hemostasis was assessed by determining tail bleeding times in CyPA -/- mice (28±3d of age) compared to age matched wild-type (WT) littermates. Blood loss during the bleeding time assays was quantified by determination of hemoglobin concentration as absorbance at 575nm. Blood was collected in EDTA tubes from the retro-orbital plexus and platelet counts were measured using an automatic hemocytometer. Flow cytometric analysis was used to determine the expression of P-selectin and fibrinogen binding in response to various agonists. Washed platelets from WT and CyPA -/- mice were allowed to spread on immobilized fibrinogen and visualized by differential interference contrast (DIC) microscopy. Results: Tail bleeding times were significantly prolonged in CyPA -/- mice (n=13) compared to WT mice (n=20) (median bleeding time: 1025 s vs. 456 s). Accordingly, blood loss during the bleeding time assay was also significantly increased in CyPA -/- mice (OD575: 0.54±0.22 vs. 0.08±0.01). CyPA -/- mice have similar platelet counts as the age matched WT mice. CyPA deficiency impaired P-selectin expression in response to thrombin and ADP plus U46619 , and fibrinogen binding in response to thrombin. Furthermore, CyPA -/- platelets had decreased filopodia and lamellipodia formation on immobilized fibrinogen. CyPA -/- platelets exhibited a decrease of 41% in spreading area as compared to WT platelets. Conclusion: These data indicate for the first time that CyPA regulates hemostasis through affecting multiple platelet functions including α-granule secretion, platelet activation and spreading.
CLOI: A Shape Classification Benchmark Dataset for Industrial Facilities (2019)

Generation of digital models of existing industrial facilities is labor intensive and expensive. The use of state-of-the-art deep learning algorithms can assist to reduce the modelling time and cost. However large databases of labelled, laser-scanned industrial facilities do not exist to date, henceforth training of deep learning models is not possible. Our paper solves this problem by proposing a new benchmark dataset, which consists of five labelled industrial plants. The labelling schema that we followed for the generation of this dataset is based on the frequency of appearance of industrial object types. We labelled the ten most frequent industrial object shapes as identified in previous work. We present CLOI (channels, L-shapes, circular sections, I-shapes): a richly annotated large-scale repository of shapes represented by labelled point clusters. CLOI has more than 140 million hand labelled points and serves as the foundation for researchers who are interested in automated modelling of industrial assets using deep learning algorithms.