gebhart/patrepeval huggingface dataset:
HEPATITIS C VIRUS (HCV) IS ASSOCIATED WITH NEW ONSET DIABETES MELLITUS (DM) AFTER LIVER TRANSPLANTATION (OLT): IMPACT ON PATIENT AND GRAFT SURVIVAL (1999)

546 Background: HCV has been associated with DM and this association may influence patient and graft survival post-OLT. Methods: 580 liver recipients (without pre-OLT DM) enrolled in the NIDDK-Liver Transplant Database between 1990-1994 were studied. Patients (320 males, 477 Caucasians, median age 48 yr, 143 HCV-positive) were assessed at wk.2, wk.4, mo.4, and then at yearly intervals for 1-5 years post-OLT. DM was defined by a requirement for anti-diabetic medications; persistent-DM (P-DM) was defined by DM present in ≥ 3 follow-up intervals with at least one interval beyond mo.4. Predictors of DM and survival were determined by logistic and Cox proportional hazard regression. Results: DM developed in 202/580 (34.9%) and 52/580 (9%) had P-DM. HCV was present in 27.2% of diabetics. HCV (OR:2.3, p=0.04), age per decade (OR:1.5, p=0.02), male gender (OR:2.7, p=0.03) and BMI (OR: 2.3, p=0.03) were independent predictors of P-DM. The overall survival for the cohort at 1, 3 and 5 yrs. was 88%, 83% and 77%, respectively. Predictors of survival were: (Table)TableWhen analysis was restricted to those who survived beyond mo.4 post-OLT, P-DM was not a predictor of survival. The commonest causes of death in the DM group was infection (32%) and in the non-DM group was recurrent disease (21%). Conclusions: HCV was one of the strongest independent predictors of DM post-OLT but did not predict survival. Diabetes at the time of death, was strongly predictive of survival but the lack of association with P-DM and late survival implies that DM effects early survival.
ChemInform Abstract: VERGLEICH DER REAKTIVITAET DER RING‐KETTEN‐ISOMEREN VON ALPHA‐GEMINAL‐DISUBSTITUIERTEN GAMMA‐ALDEHYD‐BERSTEINSAEUREN UND ‐ESTERN GEGENUEBER ORGANOMAGNESIUMVERBINDUNGEN (1972)

Abstract Methyl‐MgJ (II) reagiert selektiv mit der Form Ader Aldehydsäuren (I) zu den Säurealkoholen (III), die sich spontan zu (IV) lactonisieren.
The Intersection of Service and Sales: The Increased Importance of Ambidexterity (2019)

Blurring roles in the front line are changing how many organizations interact with their customers. Whereas frontline employees were tasked with functional roles of service or selling, an increased competitive environment and growing customer expectations have caused a shift requiring many employees to be effective at both selling and service. The growth of sales/service ambidexterity in both practice and research has prompted more meaningful investigation of the topic. The purpose of this article is to provide a brief background of ambidexterity and positioning of the topic. We provide a discussion of the articles compiled in this special issue and the synergy across papers. We conclude with the implications of this research and avenues for future research.
Offa's Dyke (1927)

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Clinical impact of bifurcation angle change between diastole and systole in complex stenting for left main distal bifurcation: The Milan and New‐Tokyo (MITO) Registry (2020)

A large BAC before stenting is strongly associated with adverse events after complex stenting for ULMD, mainly driven by repeat PCI for restenosis of the LCXos and of the LM-LAD.
ChemInform Abstract: Steroidal Lariate Ethers: A New Class of Macrocycles and the Crystal Structure of N‐(Cholesteryloxycarbonyl)aza‐15‐crown‐5. (1987)

Abstract The cholestanyl lariate ethers (III) and (VI) mentioned in the title are prepared by coupling the aza‐crowns (I) with the chlorinated steroid esters (II) or by cyclocondensation of the steroid diol (IV) with the tosylated diol (V).
The Escherichia coli chromosome contains specific, unmethylated dam and dcm sites. (1992)

The Escherichia coli chromosome encodes two methylases, dam and dcm, which recognize the sequences GATC and CC(A/T)GG, respectively. Specific dam and dcm sites on the E. coli chromosome were found to be unmethylated in vivo by using pulsed-filed gel electrophoresis experiments scanning megabase regions of DNA. Some sites were totally unmethylated. The dam sites display variable methylation depending on the local sequence, and, in general, their methylation shows complex modulation by growth conditions and growth rate, suggesting multiple protection mechanisms. Sites resistant to complete dam or dcm methylation appear to be distributed throughout the chromosome. These unusual sites may identify regions of the chromosome with interesting biological functions.
The Brief Case: Extragenitourinary Location of Oligella urethralis (2019)

A 51-year-old man was referred to the emergency department because of dyspnea and reduced oxygen saturation. He had a history of chronic alcohol abuse, cigarette smoking, and stage II chronic obstructive pulmonary disease. Ten months before, a locally advanced but stable non-small-cell lung cancer
Percutaneous Radiofrequency Ablation of Kidney Tumors (2012)

Percutaneous radiofrequency ablation (RFA) has emerged as an alternative modality for treatment of small renal tumors. The increasing use of imaging studies has allowed for early detection of renal tumors and the advent of minimally invasive nephron-sparing approaches. The use of percutaneous RFA achieves acceptable oncologic and functional outcomes when compared to partial nephrectomy, the “gold standard” in managing small renal masses. Percutaneous RFA is safe and cost-effective in treating renal tumors.
Quantum measurement and feedback control (2007)

In this paper, an overview of research in quantum control is presented. Examples of work in the first theme include numerous applications of semi-definite programming and relaxation methods in quantum information theory. Examples of the second include applications of feedback control in the development of new receiver designs for quantum-optical telecom. The third theme is just beginning to emerge as an active research area, linking fundamental issues in quantum field theory with new challenges for applied and computational mathematics in non-commutative stochastic analysis and optimization.
2016 Research Outreach Program report (2016)

This paper is the research activity report for 4 weeks in LANL. Under the guidance of Dr. Lee, who performs nuclear physics research at LANSCE, LANL, I studied the Low Energy NZ (LENZ) setup and how to use the LENZ. First, I studied the LENZ chamber and Si detectors, and worked on detector calibrations, using the computer software, ROOT (CERN developed data analysis tool) and EXCEL (Microsoft office software). I also performed the calibration experiments that measure alpha particles emitted from a Th-229 source by using a S1-type detector (Si detector). And with Dr. Lee, we checked the result.
On performance and robustness issues in the anti-windup problem (2004)

It is shown that the stability of the overall anti-windup compensated closed loop system obtained as the solution of the natural anti-windup problem can lack robustness "in the large". Subsequently, a new, weakened L/sub 2/ anti-windup problem is defined and solved by suitably modifying the approach proposed in Teel and Kapur (1997).
Beneficial effect of oocyte activation prior to and during nuclear transfer in cattle using in vitro matured oocytes 24 h of age (1995)

This research was designed to study in vitro development of bovine nuclear transferred embryos using enucleated young in vitro matured oocytes 24 h of age as recipient cytoplasts activated prior to nuclear transfer. The oocytes were enucleated and then activated with electric pulse at 24 h of age followed by incubation with cycloheximide for 6-7 h before nuclear transfer and membrane fusion with a blastomere of the 16-32 cell stage. This new protocol effectively improved cleavage (68 vs 17%, p < 0.05) and morula/blastocyst development of reconstructed embryos (29 vs 6%, p < 0.05), compared to similar nuclear transfer procedure without prior activation of recipient oocytes. Corresponding rates of cleavage and morula/blastocyst development for oocytes activated similarly without nuclear transfer were 49 and 19%. Factors affecting nuclear transfer were also compared. Two electric pulses for fusion increased rates of fusion (76 vs 60%, p < 0.05) and subsequent development of cloned embryos (32 vs 11%, p < 0.05). Cytochalasin B treatment following nuclear transfer manipulation seemed not to be beneficial in improving development of cloned embryos (p > 0.05). Both co-culture systems with buffalo rat liver (BRL) cells and cumulus cells promoted development of cloned embryos compared to the controls (28, 21 vs 0%, p < 0.05). The BRL cell system seemed to be better for manipulated embryos by reducing embryolysis.
Temporal and operation-induced instability of apparent soil electrical conductivity measurements (2023)

Measuring apparent soil electrical conductivity (EC a ), using galvanic contact resistivity (GCR) and electromagnetic induction (EMI) techniques, is frequently conducted to reveal spatial soil heterogeneity. Various studies have demonstrated the possibilities for significant changes in the measured quantities over time with relatively stable spatial structure representations. The objective of this study was to quantify the effects of temporal drift and operational noise for three popular EC a mapping instruments. They were placed in stationary positions approximately 8 m apart in an area with relatively low EC a . Temporal drift was assessed using a series of 4.5-h data logs recorded under different weather conditions (from extremely hot to near freezing temperatures). The two EMI instruments were also used to quantify the effect of minor changes in the height, pitch and roll of the sensor with respect to the ground. These operational noise tests were replicated over several days. Our results reveal the GCR measurements of EC a , along with perpendicular coplanar EMI measurements, have shown relatively strong stability over time. Each operational effect introduced measurement uncertainties comparable to the impact of a change in temperature and soil water content.
Europa ha sido líder en llevar el humor a la publicidad: Gerald M. Goldberg, presidente del Festival de Nueva York. (1989)

En opinion de Gerald M. Goldberg, presidente y director de los Festivales de Cine y Television, Radio y publicidad impresa de Nueva York, Europa ha sido lider en llevar el humor a la publicidad y dispone de un nivel creativo muy interesante, mientras Estados Unidos es lider en marketing. Para el, el gran reto de los proximos anos va por el camino de realizar un marketing directo que ademas sea creativo. Goldberg ha visitado recientemente Espana para presentar el palmares del festival Internacional de Cine y TV de Nueva York. El acto fue organizado en Barcelona por las agencias Cid y Tagg y la revista Control.
System Identification of Space Structure Using Semi-Active Control Subject to Unknown Disturbance (2019)

In this paper, we propose a new system identification method of space structures. Considering operations of space structures, excitation force is usually unmeasurable and unknown. Instead of measuring excitation force, voltage of a piezoelectric transducer that is installed to the space structure is measured. The piezoelectric voltage can be used as an input signal to the structure because it is proportional to the force generated by the piezoelectric transducer. We consider that the excitation force can be represented as unknown periodic functions that are handled as an internal state of the system. Then, system identification is enforceable without measuring the excitation force. Also, two improvements are achieved in general system identification theory in this paper. First, we consider about uncontrollability of the system. The system that deals with the excitation force as internal state has some uncontrollable parts. Second, we introduce a forgetting factor to the sequential system identification theory, which is effective when characteristics of the space structure can be changed. We present performances of the proposed method in the numerical simulation. The simulation result shows that system identification can be implemented measuring the piezoelectric voltage without measuring the excitation force. In addition, it is showed that the proposed method adapts quickly to the change in structural condition.
Similarity and Equivalence of Nutating Mechanisms to Bevel Epicyclic Gear Trains for Modeling and Analysis (2005)

This paper addresses similarities between various nutating or wobbling mechanisms, in particular kinematic similarities. A case is made for the generalization of these mechanisms into a mechanism “class” having common kinematic characteristics, which is typified by bevel epicyclic gear trains. A similarity index is proposed to describe the quality of kinematic similarity, with the best degree of similarity termed “equivalence.” It is proposed that kinematic analysis of mechanisms belonging to this “class” can be simplified by modeling them as bevel-gear trains, and that static-force, power-flow, and efficiency analyses can also be greatly simplified in the case of “equivalent” mechanisms. Simplified kinematic, force, and efficiency analyses are demonstrated for a unique wobbling speed reducer using this new concept of equivalent geared mechanisms.
Equipement optique des sujets atteints de dégénérescence maculaire senile exsudative (1986)

Aging exudative macular degeneration frequently results in a fibrovascular scar which entails the loss of central vision. This scar implies an often large and deep scotoma which makes it very difficult for the patient to be fitted with low-vision aids. A Goldmann static perimetry study of retinal sensitivity in the treated areas showed that krypton laser at liminar doses does not induce deep scotomas.
High Cell Selectivity and Low-Level Antibacterial Resistance of Designed Amphiphilic Peptide G(IIKK)3I-NH2 (2014)

On the basis of cell cultures involving bacterial strains (Escherichia coli 5α and Bacillus subtilis 168) and a mammalian cell line (NIH 3T3), the potent antibacterial activity and distinct selectivity from designed amphiphilic peptides G(IIKK)nI-NH2 (n = 2-4) have been demonstrated. This work extends these studies to multidrug resistant pathogens (ESBL-producing E. coli) and primary human cells (HDFa), followed by the in vivo mouse model investigation of ESBL-producing bacterial infection. G(IIKK)3I-NH2 exhibits high antibacterial activity against the pathogenic strain both in vitro and in vivo while displaying low toxicity toward the primary cells and the mice. Peptide molecules can kill bacteria by selectively interacting with bacterial membranes, causing structural disruptions. Furthermore, multidrug resistant ESBL-producing bacteria do not develop resistance after multiple treatments with G(IIKK)3I-NH2. The high cellular selectivity, low toxicity toward mammalian hosts and noninducing bacterial resistance indicate great potential for developing the peptides as anti-infection agents.
A Zero Public Infrastructure Vehicle Based Traffic Information System (2003)

This paper introduces an innovative completely decentralized vehicle- based traffic information system that does not involve any public investment from government agencies to build, manage and maintain the necessary infrastructure; it relies, instead, on information exchanged by the vehicles themselves. We present the basic design issues and perform some initial analysis for an idealized freeway at various levels of market penetration and congestion. Relationships are derived for the propagation speed of the information wave versus that of the traffic shock wave in case of bottlenecks. On a network, similar results are produced from a modified simulator. Finally, the communication needs are analyzed assuming that the IEEE 802.11 wireless communication standards for inter-vehicle is adopted
Integrative Modeling Identifies Key Determinants of Inhibitor Sensitivity in Breast Cancer Cell Lines (2018)

Cancer cell lines differ greatly in their sensitivity to anticancer drugs as a result of different oncogenic drivers and drug resistance mechanisms operating in each cell line. Although many of these mechanisms have been discovered, it remains a challenge to understand how they interact to render an individual cell line sensitive or resistant to a particular drug. To better understand this variability, we profiled a panel of 30 breast cancer cell lines in the absence of drugs for their mutations, copy number aberrations, mRNA, protein expression and protein phosphorylation, and for response to seven different kinase inhibitors. We then constructed a knowledge-based, Bayesian computational model that integrates these data types and estimates the relative contribution of various drug sensitivity mechanisms. The resulting model of regulatory signaling explained the majority of the variability observed in drug response. The model also identified cell lines with an unexplained response, and for these we searched for novel explanatory factors. Among others, we found that 4E-BP1 protein expression, and not just the extent of phosphorylation, was a determinant of mTOR inhibitor sensitivity. We validated this finding experimentally and found that overexpression of 4E-BP1 in cell lines that normally possess low levels of this protein is sufficient to increase mTOR inhibitor sensitivity. Taken together, our work demonstrates that combining experimental characterization with integrative modeling can be used to systematically test and extend our understanding of the variability in anticancer drug response.<b>Significance:</b> By estimating how different oncogenic mutations and drug resistance mechanisms affect the response of cancer cells to kinase inhibitors, we can better understand and ultimately predict response to these anticancer drugs.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/15/4396/F1.large.jpg <i>Cancer Res; 78(15); 4396-410. ©2018 AACR</i>.
Hybrid Carbon Nanotube/Nanodiamond Structures as Electron Emitters for Cold Cathodes (2008)

The field emission properties of hybrid carbon nanotubes/nanodiamond structures produced by one-step chemical vapor deposition (CVD) process have been investigated in order to assess their application as electron emitters for cold cathodes. The electron emission properties of a series of samples have been investigated by current–pressure, current–voltage and current–time measurements with the aim of testing the emission stability under working conditions relevant to technological applications. Stable emission, high values of current density and lack of arcing have been observed during prolonged working cycles, and without degradation of the material structure.
Image fusion of the Terahertz-visual NAECON Grand Challenge data (2012)

Terahertz (THz) sensing has been developed over the past three decades for concealed weapons detection, medical imaging, and non-destructive evaluation; however methods for THz image exploitation have not been well reported. We test a multiscale image fusion algorithm for the 2011 IEEE National Aerospace and Electronics Conf. (NAECON) Grand Challenge which consists of Terahertz (THz) and visual images. The study consists of image characterization (signals distribution), image processing (data fusion), and image analysis (edge detection). We found that THz image characterization did not necessarily follow a distinct Gaussian distribution, THz imagery fusion with visual data supported target detection, and that image analysis enhanced target assessment. For the initial experiment, we assess the target segmentation through edge detection, image fusion results, and image fusion quality assessment. The preliminary image exploitation and fusion results can further develop THz collection over clothing-obscured concealed weapons imaging, parameter optimization, and targeting evaluation.
Hydration Status Response To Bolus Frequency And Volume Intake During Exercise In Heat (2020)

Workplace hydration recommendations suggest consuming 237mL of fluid every 15-20 min during physical work in the heat. It is unknown if these recommendations promote hydration during work and if consuming larger boluses of water less frequently maintains hydration better than smaller boluses of water consumed more frequently. PURPOSE: Examine if consuming 500mL water every 40 min maintains hydration better than 237mL water every 20 min during work in the heat. METHODS: Seven healthy adults completed 2 trials while fasted, either consuming 237mL water every 20 min (237) or 500mL water every 40 min (500). Subjects performed 2 h of treadmill exercise at 6.4kph, 1.0% grade in 34°C, 30% relative humidity wearing shorts and a t-shirt, followed by 2 h of rest in a temperate room. Heart rate (HR), rectal temperature (Trec), skin temperature (Tskin), were measured throughout exercise and recovery. Gastrointestinal (GI) symptoms were measured during exercise. Nude body mass was measured pre- and post-exercise. Blood and urine samples were collected pre- and post-exercise, and after recovery. RESULTS: HR, Trec, and Tskin increased from pre- (58±10, 62±9 bpm; 36.8±0.3, 36.7±0.3°C; 32.3±0.4, 32.3±0.9°C) to post- (132±29, 136±33 bpm, p=0.01; 38.1±0.6, 38.0±0.7°C, p=0.01; 35.5±0.6, 35.6±1.1°C, p<0.01) exercise and returned to baseline (62±10, 68±15 bpm, p=0.88; 36.7±0.2, 36.7±0.2°C, p=1.00; 32.9±0.7, 32.6±1.0°C, p=0.89) following recovery, in 237 and 500, respectively. GI symptoms were similar among trials and times (p=0.38). In 500, urine specific gravity was lowest following recovery (1.005±0.003) compared to pre- (1.015±0.002, p<0.01) and post- (1.011±0.006, p=0.02) exercise. Plasma osmolality was not different between post-exercise (282±3, 281±4 mOsm/L) and recovery (283±1, 284±2 mOsm/L) compared to pre-exercise (287±6, 286±3 mOsm/L, p=0.96) in 237 and 500, respectively. Changes in plasma volume were similar among trials and times (p=0.78). Post-exercise body mass loss (-0.1±0.5, 0.0±0.5 kg, p=0.28) and sweat rate (0.7±0.2, 0.6±0.5 L/h, p=0.41) were similar, in 237 and 500, respectively. CONCLUSIONS: Hydration status was similar between drinking larger, less frequent water boluses and smaller, more frequent boluses. These findings provide flexibility for workers to take less frequent hydration breaks.
Heterometallic CoIII–GdIII Clusters as Magnetic Refrigerants (2016)

Two heterometallic Co(III)-Gd(III) nanomagnets (Co2Gd6 and Co2Gd9) with defective dicubane-like cores were isolated from the same set of reactants by varying the reaction conditions. These are the first examples of cobalt(III)-gadolinium(III) phosphonate compounds and a rare class of compounds with large 4f ratio among the reported 3d-4f complexes. Magnetic studies reveal large magnetic entropy changes for both complexes (-ΔSm = 27.81 and 33.07 J kg(-1) K(-1), respectively at 3 K and 7 T).