gebhart/patrepeval huggingface dataset:
Series resonant inverter with active snubber circuit for improved efficiency operation applied to domestic induction heating (2013)

Efficiency is a key design parameter for domestic induction heating systems. To achieve this aim, resonant converters featuring soft switch on transitions are commonly used. In this paper, a cost-effective active snubber circuit is proposed to optimize the switch off transition. This allows the converter to operate under a wide range of operating conditions, with optimized asymmetrical control strategies, and allows the designer to select slower power devices with optimized conduction parameters. The proposed circuit has been tested with a 4-kW series resonant inverter.
MODE-SPECIFICITY IN PHOTODISSOCIATION OF FUNDAMENTAL STRETCHINGS OF HOD (1991)

Stimulated Raman excitation and coherent anti-Stokes Raman scattering prepare and detect, respectively, HOD molecules with one quantum of vibrational excitation in the O-H or O-D stretch vibrations. An ArF excimer laser at 193 nm promotes vibrationally excited molecules to the first electronic surface A(1B1) where they dissociate to produce OH + D or OD + H fragments. The photodissociation products OD and OH are detected via laser induced fluorescence. The photodissociation cross section of HOD (0,0,l) vibrationally excited molecules with one quantum of vibration in the O-H stretch is greatly enhanced over that for HOD (0,0,0). The dissociation of this vibrationally excited molecule is also very selective, the OD + H yield being 2.5±0.5 times greater than the OH + D yield. In the photodissociation of the O-D stretch, excited HOD (l,0,0), no enhancement of the yield of the fragments is obtained. Also, these results demonstrate that bond cleavage does not necessarily occur on the weakened bond, and they agree with theoretical calculations indicating that the yield of OD and OH fragments depends on the Franck-Condon overlap of the ground state vibrational wavefunction with the continuum wavefunction on the repulsive surface of the upper state. Our results show that even the very lowest possible level of vibrational excitation can be "leveraged" to effect selective bond breaking.
A multi‐intervention approach on drug therapy can lead to a more appropriate drug use in the elderly. LIMM‐Landskrona Integrated Medicines Management (2009)

This kind of systematic approach on drug therapy can result in a more appropriate drug use in the elderly.
Abnormal Venous Drainage Simulating a Glomus Jugulare Tumor (1983)

Knowledge of the arterial supply and the venous drainage of a glomus jugulare tumor is of most importance for surgery, and close cooperation between the neuroradiologist and the otolaryngologist is necessary. The possibility of a variation of the vascular anatomy should be kept in mind. We report a patient with a reddish mass behind the eardrum which was found to be her transverse sinus running in a vertical direction, ending in a sigmoid sinus which was passing close to the foramen magnum.
MLN4924 protects against interleukin-17A-induced pulmonary inflammation by disrupting ACT1-mediated signaling (2019)

An excessive inflammatory response in terminal airways, alveoli, and the lung interstitium eventually leads to pulmonary hypertension and chronic obstructive pulmonary disease. Proinflammatory cytokine interleukin-17A (IL-17A) has been implicated in the pathogenesis of pulmonary inflammatory diseases. MLN4924, an inhibitor of NEDD8-activating enzyme (NAE), is associated with the treatment of various types of cancers, but its role in the IL-17A-mediated inflammatory response has not been identified. Here, we report that MLN4924 can markedly reduce the expression of proinflammatory cytokines and chemokines such as IL-1β, IL-6, and CXCL-1 and neutrophilia in a mouse model of IL-17A adenovirus-induced pulmonary inflammation. MLN4924 significantly inhibited IL-17A-induced stabilization of mRNA of proinflammatory cytokines and chemokines in vitro. Mechanistically, MLN4924 significantly blocked the activation of MAPK and NF-κB pathways and interfered with the interaction between ACT1 and tumor necrosis factor receptor-associated factor proteins (TRAFs), thereby inhibiting TRAF6 ubiquitination. Taken together, our data uncover a previously uncharacterized inhibitory effect of MLN4924 on the IL-17A-mediated inflammatory response; this phenomenon may facilitate the development of MLN4924 into an effective small-molecule drug for the treatment of pulmonary inflammatory diseases.
Nascent Pieces of ϕ X174 Viral-strand DNA Are Shorter Than Unit-length and Are Derived from All Regions of the Genome (1978)

There is good evidence that the synthesis of the two strands of ϕ X174 replicative-form (RF) DNA is asymmetric—i.e., that in each “round” of replication the viral strand is synthesized continuously and the complementary strand is synthesized discontinuously (Denhardt 1977). It is also commonly believed that once viral-strand synthesis is initiated, the DNA polymerase then simply moves around the complementary-strand ring indefinitely (Dressler 1970; Watson 1976). This was first promulgated as the rolling-circle model (Gilbert and Dressler 1969). According to this concept, the viral strand is elongated “endlessly” from the 3′-OH primer created by the insertion of a nick into the viral strand by the ϕ X gene- A protein; the circular complementary strand serves repeatedly as the template, in the fashion of a “stamping machine.” This simple mechanism produces, as an intermediate, a viral strand longer than unit length, and evidence for the existence of such strands under certain conditions has been reported (Dressler and Wolfson 1970; Eisenberg et al. 1977; Baas and Jansz, this volume). However, little by little, data have been accumulating that bring this model into question. First, it was shown that a gap exists at a specific location in the viral strand of newly synthesized RF molecules produced during RF DNA replication (Eisenberg and Denhardt 1974; Eisenberg et al. 1975) and during progeny viral-strand DNA synthesis (Johnson and Sinsheimer 1974). Second, the dnaG protein of Escherichia coli , which is thought to produce primers for initiating DNA synthesis, is required for viral-strand synthesis as well as...
The Use of an Acylhydrazone-Based Metal-Organic Framework in Solid-Contact Potassium-Selective Electrode for Water Analysis (2022)

A solid-contact ion-selective electrode was developed for detecting potassium in environmental water. Two versions of a stable cadmium acylhydrazone-based metal organic framework, i.e., JUK-13 and JUK-13_H2O, were used for the construction of the mediation layer. The potentiometric and electrochemical characterizations of the proposed electrodes were carried out. The implementation of the JUK-13_H2O interlayer is shown to improve the potentiometric response and stability of measured potential. The electrode exhibits a good Nernstian slope (56.30 mV/decade) in the concentration range from 10−5 to 10−1 mol L−1 with a detection limit of 2.1 µmol L−1. The long-term potential stability shows a small drift of 0.32 mV h−1 over 67 h. The electrode displays a good selectivity comparable to ion-selective electrodes with the same membrane. The K-JUK-13_H2O-ISE was successfully applied for the determination of potassium in three certified reference materials of environmental water with great precision (RSD &lt; 3.00%) and accuracy (RE &lt; 3.00%).
Flowable Networks as Equilibrium DNA Sequencing Media in Capillary Columns (1996)

We describe a novel class of materials that self-assemble into equilibrium network structures with a well-defined pore size that permit electrophoretic DNA sequencing, in capillary columns, with excellent reproducibility. These polymers, poly(ethylene glycols) end-capped with micelle-forming fluorocarbon tails, form flowable aqueous networks that have unusual rheological properties.
An approach to evolving database dependent systems (2002)

It is common in client/server architectures for components to have SQL statements embedded in their source code. Components submit queries to relational databases using such standards as Universal Data Access (UDA) and Open Database Connectivity (ODBC). The API that implements these standards is complex and requires the embedding of SQL statements in the language that is used to write the components. Such programming practices are widespread and result in increased complexity in maintaining systems.We propose an approach that eliminates the embedding of SQL in programming languages, thereby enabling the automation of important software maintenance tasks.
GaP source-drain vertical transistor on bulk silicon for 1-transistor DRAM application (2013)

GaP is proposed as source and drain material for 1-transistor DRAM application as it is nearly lattice matched to silicon and provides a valence band offset of ∼ 1 eV. Simulations of retention time for the proposed vertical structure indicate: large improvement over similar bulk silicon devices, ability to meet ITRS requirement and good scalability. An MOCVD recipe is optimized for GaP growth on silicon and further characterized by fabricating electrical devices such as diodes and transistors indicating feasibility for usage in 1T-DRAM technology.
System support for bandwidth management and content adaptation in internet applications (2000)

This paper describes the implementation and evaluation of an operating system module, the Congestion Manager (CM), which provides integrated network flow management and exports a convenient programming interface that allows applications to be notified of, and adapt to, changing network conditions. We describe the API by which applications interface with the CM, and the architectural considerations that factored into the design. To evaluate the architecture and API, we describe our implementations of TCP; a streaming layered audio/video application; and an interactive audio application using the CM, and show that they achieve adaptive behavior without incurring much end-system overhead. All flows including TCP benefit from the sharing of congestion information, and applications are able to incorporate new functionality such as congestion control and adaptive behavior.
A Novel Sequence-phase Coupled Model for Active Distribution Network based on Modelica (2018)

The analysis of active distribution networks is the basis of Energy Internet control and management. As the penetration of distributed renewable energy into distribution networks has increased, traditional applications, such as OpenDSS, are not suitable for analyzing networks that contain distributed generators (DGs). For distribution network calculation, three-phase DGs are often modeled in sequence frame, while the three-phase unbalanced distribution networks are usually modeled in phase frames. Hence, this paper represents a novel model that could deal with both frames by load flows in a sequence-phase coupled frame. The steady state analysis model presented in this paper is implemented using an open source language called Modelica. Tests on the IEEE testing systems are carried out and the results demonstrate the advantage of the model.
Killing of Bacillus subtilis Spores by a Modified Fenton Reagent Containing CuCl 2 and Ascorbic Acid (2004)

Bacillus subtilis spores were killed by CuCl(2)-ascorbic acid, chloride ions were essential for killing of spores, and spores with defective coats were killed more rapidly. CuCl(2)-ascorbic acid did not damage spore DNA, and spores killed by this reagent initiated germination. However, spores killed by CuCl(2)-ascorbic acid may have damage to their inner membrane.
ChemInform Abstract: Design and Synthesis of Highly Potent Vitamin D Receptor Antagonists Based on the Structural Development of Vitamin D3‐26,23‐Lactone (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Novel Giant Siphovirus from Bacillus anthracis Features Unusual Genome Characteristics (2014)

Here we present vB_BanS-Tsamsa, a novel temperate phage isolated from Bacillus anthracis, the agent responsible for anthrax infections in wildlife, livestock and humans. Tsamsa phage is a giant siphovirus (order Caudovirales), featuring a long, flexible and non-contractile tail of 440 nm (not including baseplate structure) and an isometric head of 82 nm in diameter. We induced Tsamsa phage in samples from two different carcass sites in Etosha National Park, Namibia. The Tsamsa phage genome is the largest sequenced Bacillus siphovirus, containing 168,876 bp and 272 ORFs. The genome features an integrase/recombinase enzyme, indicative of a temperate lifestyle. Among bacterial strains tested, the phage infected only certain members of the Bacillus cereus sensu lato group (B. anthracis, B. cereus and B. thuringiensis) and exhibited moderate specificity for B. anthracis. Tsamsa lysed seven out of 25 B. cereus strains, two out of five B. thuringiensis strains and six out of seven B. anthracis strains tested. It did not lyse B. anthracis PAK-1, an atypical strain that is also resistant to both gamma phage and cherry phage. The Tsamsa endolysin features a broader lytic spectrum than the phage host range, indicating possible use of the enzyme in Bacillus biocontrol.
Expression of the Acid α‐Naphthyl Acetate Esterase Marker by Activated and Secondary T Lymphocytes in Man (1977)

Acid alpha-naphthyl acetate esterase (ANAE) activity is characteristic of resting human T lymphocytes. The expression of the ANAE marker by activated human T and B lymphocytes (blasts) and by corresponding 'secondary' lymphocytes has been investigated. Human blood lymphocytes were stimulated by selective T-cell (phytohemagglutinin (PHA) and concanavalin A (Con A)) or B-cell (Staphylococcus aureus strain Cowan 1) mitogens or in the mixed lymphocyte culture (MLC), and the percentage of blasts expressing the marker was quantiated. Whereas 95% of Con-A-activated blasts expressed the marker, approximately 25%-30% of MLC-activated blasts and only 10%-25% of PHA-activated blasts were ANAE-positive. After reversion to secondary lymphocytes, the PHA- and MLC-activated cells regained the ANAE activity, and more than 90% of the blast-derived secondary T lymphocytes were ANAE-positive. Only 2%-8% of blast cells activated by Staphylococcus aureus strain Cowan 1 were ANAE-positive. We therefore conclude that ANAE is not a reliable marker for T cells when activated cells (blasts) are considered.
The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. (2003)

Ethanol is a chemically simple compound that produces many well-known effects in humans. The prevailing idea for many years was that ethanol and other alcohols exerted their effects on the central nervous system (CNS) by non-selectively disrupting the lipid bilayers of neurons. However, in recent years, there has been an accumulation of evidence pointing to the importance of ligand-gated ion channels (LGICs) in mediating the effects of ethanol. Of these LGICs, gamma-aminobutyric acid type A (GABAA) receptors appear to occupy a central role in mediating the effects of ethanol in the CNS. GABA is the primary inhibitory neurotransmitter in the mammalian CNS, and activation of GABAA receptors by GABA tends to decrease neuronal excitability. This article reviews several aspects of GABAA receptor and ethanol interactions, including the evidence for short- and long-term modulation of GABAA receptors by ethanol and evidence for a GABAA receptor-related genetic component of alcoholism.
Is R2 resection a valuable salvage treatment for colorectal liver metastases? (2015)

e14602 Background: Patients with multiple colorectal liver metastases (CRLM) are always considered in an intention to resect all metastases (R0/R1resection). However technical constraints make that sometimes no more than a R2 (incomplete) resection can be achieved, The results of these procedures of debulking surgery in CRLM have never been evaluated in a period of increasing efficacy of chemotherapy Methods: The study consists in a retrospective analysis of all the consecutive patients with CRLM treated by a first R2 liver resection, from 1994 to 2012 at a single center Characteristics of patients (age, sex), of metastases (date of diagnosis, number and size, tumor markers), of chemotherapy received preoperatively (type, number of cycles, response according to Recist criteria) and of liver surgery (date, cause for R2) were correlated to the patient outcome. Volumes for all liver metastases were calculated: in CT scan and on pathological report. A percentage of tumor left was calculated based on the substraction of both for all metastases. Results: Among a global cohort of 1170 patients resected of CRLM, 172 had resections identified as R2 (100%). Of these, 93 (54%) were first stage hepatectomies that succesfully completed a two-stage hepatectomy, while the remaining 79 patients had true R2 resections (45.9%) with no extra-hepatic disease and formed the study population. R2 resection was due to failed two-stage hepatectomy in 46 (58.2%) patients, failure to accomplish a maximal one-stage resection in 11 (13.9%); an ill located tumor in 8 (10%) or other causes in 14 (17%). The mean percentage of tumor left in situwas 63.8% of all the tumor load with 24% of patients having < 30% residual tumor. A partial response to preoperative chemotherapy was observed in 55.6% with stabilisation in 29% and progression in 15%. For all patients with R2 resection, 5-year survival rate was 28% and the median survival was 39 months. For patients with a combination of response to chemotherapy and < 30% of tumor left in place, the 5-year survival rate was 54% and the median survival was 95 months. Conclusions: R2 resection may allow selected patients to achieve long-term survival provided that chemotherapy is efficient and remnant tumoral load is low.
Fission Yeast Rad51 and Dmc1, Two Efficient DNA Recombinases Forming Helical Nucleoprotein Filaments (2005)

Homologous recombination is important for the repair of double-strand breaks during meiosis. Eukaryotic cells require two homologs of Escherichia coli RecA protein, Rad51 and Dmc1, for meiotic recombination. To date, it is not clear, at the biochemical level, why two homologs of RecA are necessary during meiosis. To gain insight into this, we purified Schizosaccharomyces pombe Rad51 and Dmc1 to homogeneity. Purified Rad51 and Dmc1 form homo-oligomers, bind single-stranded DNA preferentially, and exhibit DNA-stimulated ATPase activity. Both Rad51 and Dmc1 promote the renaturation of complementary single-stranded DNA. Importantly, Rad51 and Dmc1 proteins catalyze ATP-dependent strand exchange reactions with homologous duplex DNA. Electron microscopy reveals that both S. pombe Rad51 and Dmc1 form nucleoprotein filaments. Rad51 formed helical nucleoprotein filaments on single-stranded DNA, whereas Dmc1 was found in two forms, as helical filaments and also as stacked rings. These results demonstrate that Rad51 and Dmc1 are both efficient recombinases in lower eukaryotes and reveal closer functional and structural similarities between the meiotic recombinase Dmc1 and Rad51. The DNA strand exchange activity of both Rad51 and Dmc1 is most likely critical for proper meiotic DNA double-strand break repair in lower eukaryotes.
Vandalism detection in Wikipedia (2011)

User generated content (UGC) constitutes a significant fraction of the Web. However, some wiiki-based sites, such as Wikipedia, are so popular that they have become a favorite target of spammers and other vandals. In such popular sites, human vigilance is not enough to combat vandalism, and tools that detect possible vandalism and poor-quality contributions become a necessity. The application of machine learning techniques holds promise for developing efficient online algorithms for better tools to assist users in vandalism detection. We describe an efficient and accurate classifier that performs vandalism detection in UGC sites. We show the results of our classifier in the PAN Wikipedia dataset. We explore the effectiveness of a combination of 66 individual features that produce an AUC of 0.9553 on a test dataset -- the best result to our knowledge. Using Lasso optimization we then reduce our feature--rich model to a much smaller and more efficient model of 28 features that performs almost as well -- the drop in AUC being only 0.005. We describe how this approach can be generalized to other user generated content systems and describe several applications of this classifier to help users identify potential vandalism.
Human Pluripotent Stem Cells from Bone Marrow (2003)

Stem cells have become a major area of discussion both in scientific journals and in the lay press (1). The ethical implications of using embryonic stem (ES) cells along with new scientific evidence of the greater potential of adult stem cells have stimulated the debate regarding the need for human ES cells for therapies (2,3). In the next chapter, we will discuss some of the existing evidence that pluripotent adult stem cells can be derived from bone marrow (BM) or other postnatal tissues. We will not limit our discussion to human cells, as most of the studies so far suggesting that pluripotent adult stem cells exist are based on animal models.
The Potential of a Continuous Process for the Valorization of Lignin in Aqueous Media Assisted By Heterogeneous Catalysts (2015)

SSCI-VIDE+CDFA+WSE:LDJ:PFO
Phylogenetic relationships of the callitrichinae (Platyrrhini, Primates) based on ?2-microglobulin DNA sequences (1999)

The phylogenetic relationships of callitrichine primates have been determined by DNA sequence analyses of exons 1, 2, and 3 of the beta2-microglobulin gene. Parsimony, distance, and maximum likelihood analyses of ca. 900 base pairs of 21 taxa, representing all callitrichine genera, indicated that Saguinus was the most basal offshoot. Within Saguinus, S. fuscicollis appeared as the first divergent lineage followed by an unresolved trichotomy formed by S. mystax/S. imperator, S. midas/S. bicolor, and S. oedipus. A second callitrichine lineage was formed by Leontopithecus; each of the three species studied showed identical nucleotide sequences. Callimico appeared as the sister taxon of Callithrix/Cebuella. Genetic distances within this latter group were very small, although a stronger association between Cebuella and species of the Callithrix argentata group was observed. The inclusion of Cebuella in the genus Callithrix is suggested. These studies indicated that tamarins are more plesiomorphic than marmosets in agreement with the phyletic dwarfism hypothesis.
Usability Evaluation of an Unstructured Clinical Document Query Tool for Researchers. (2018)

Natural Language Processing - Patient Information Extraction for Researchers (NLP-PIER) was developed for clinical researchers for self-service Natural Language Processing (NLP) queries with clinical notes. This study was to conduct a user-centered analysis with clinical researchers to gain insight into NLP-PIER's usability and to gain an understanding of the needs of clinical researchers when using an application for searching clinical notes. Clinical researcher participants (n=11) completed tasks using the system's two existing search interfaces and completed a set of surveys and an exit interview. Quantitative data including time on task, task completion rate, and survey responses were collected. Interviews were analyzed qualitatively. Survey scores, time on task and task completion proportions varied widely. Qualitative analysis indicated that participants found the system to be useful and usable in specific projects. This study identified several usability challenges and our findings will guide the improvement of NLP-PIER 's interfaces.