gebhart/patrepeval huggingface dataset:
The aftermath of Aboriginal suicide: Lived experience as the missing foundation for suicide prevention and postvention (2017)

This paper aimed to highlight the systemic and theoretical barriers for Aboriginal and Torres Strait Islander people who have been bereaved by suicide. Incorporating the lived experiences of two advocates, Leilani Darwin and Julie Turner, and professional experiences of Matthew Trindall and Laura Ross, the paper explores the importance of including Aboriginal lived experiences in programs for Indigenous suicide prevention. Informed equally by an analysis of the lived experience and suicide prevention literature and the common themes presented throughout the lived experience accounts, it is recommended that more Indigenous-specific research is conducted in the sphere of lived experience in suicide bereavement, as well as dedicated effort to mentor and develop Aboriginal and Torres Strait Islander people with lived experience and support them to influence and design prevention strategies at a local level.
Experimental facial myokymia in cat (1997)

Facial movements in cats similar to myokymia in humans accompanies kainic acid injections adjacent to the nucleus of the facial nerve.
Tau isoform‐specific modulation of kinesin‐driven microtubule gliding rates and trajectories as determined with tau‐stabilized microtubules (2010)

We have utilized tau-assembled and tau-stabilized microtubules (MTs), in the absence of taxol, to investigate the effects of tau isoforms with three and four MT binding repeats upon kinesin-driven MT gliding. MTs were assembled in the presence of either 3-repeat tau (3R tau) or 4-repeat tau (4R tau) at tau:tubulin dimer molar ratios that approximate those found in neurons. MTs assembled with 3R tau glided at 31.1 μm/min versus 25.8 μm/min for 4R tau, a statistically significant 17% difference. Importantly, the gliding rates for either isoform did not change over a fourfold range of tau concentrations. Further, tau-assembled MTs underwent minimal dynamic instability behavior while gliding and moved with linear trajectories. In contrast, MTs assembled with taxol in the absence of tau displayed curved gliding trajectories. Interestingly, addition of 4R tau to taxol-stabilized MTs restored linear gliding, while addition of 3R tau did not. The data are consistent with the ideas that (i) 3R and 4R tau-assembled MTs possess at least some isoform-specific features that impact upon kinesin translocation, (ii) tau-assembled MTs possess different structural features than do taxol-assembled MTs, and (iii) some features of tau-assembled MTs can be masked by prior assembly by taxol. The differences in kinesin-driven gliding between 3R and 4R tau suggest important features of tau function related to the normal shift in tau isoform composition that occurs during neural development as well as in neurodegeneration caused by altered expression ratios of otherwise normal tau isoforms.
Cytotoxicity control of SiC nanoparticles introduced into polyelectrolyte multilayer films (2014)

Nowadays, biosensor technology development is directed toward improvement of sensing devices' biocompatibility.
Aromatic Hydrocarbon‐Catalyzed Direct Reaction of Sulfur and Sodium in a Heterogeneous System: Selective and Facile Synthesis of Sodium Monosulfide and Disulfide. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Robust Key Generation With Hardware Mismatch for Secure MIMO Communications (2021)

In practical implementations, physical-layer key generation (PKG) encounters the bottlenecks of imperfect channel reciprocity, nearby attack, and high temporal auto-correlation. Existing One-Band Multiple-Antenna Loop-bAck key generation (OB-MALA) schemes try to address these challenges through establishing bi-directional channels via echoing rotated received signals. However, we find that OB-MALA schemes can be vulnerable to a multiply-divide (MD) attack, as they echo the received signals through the same band with the pilot signals. To overcome this deficiency, we propose a new method, named Two-Band Multiple-Antenna Loop-bAck key generation (TB-MALA), which exploits two separate bands for pilot transmission and echo reception. The TB-MALA is proved to be robust to the imperfect channel reciprocity caused by radio frequency (RF) front-ends and can resist both the nearby attack and the MD attack. It also reduces the auto-correlation of effective channels with the help of a rotation matrix. The secret key rate of TB-MALA is analyzed and the closed-form of a lower bound is derived for the worst case. Numerical results demonstrate that the proposed TB-MALA protects against these attacks and achieves performance comparable to the ideal case with the perfect reciprocity of RF front-ends. It can thus be used to form a robust, fast, and secure key generation in a multiple-input and multiple-output (MIMO) system.
The molecular genetics of mood disorders (1997)

In the past year, a further seven sites were linked to bipolar illness.Increasingly, it is recognized that mood disorders are multigenic, with only a few families showing determinant genes. Recent studies concentrated on multigenomic linkage studies of genetically isolated pedigrees but future research may be better served by association studies and multicentre co-operation.
Laser Emission from Electrospun Polymer Nanofibers (2009)

Fully organic nanofiber lasers, made by a polymer matrix doped with gain molecules, are demonstrated. They exhibit emission in the visible and near infrared range (see image), supporting efficient waveguiding of the self-emitted light. Individual fibers can operate as optical cavities, emitting single-mode laser light at visible wavelengths with a threshold of tens of µJ cm−2.
Treatment of statin adverse effects with supplemental Coenzyme Q10 and statin drug discontinuation (2005)

Fifty consecutive new cardiology clinic patients who were on statin drug therapy (for an average of 28 months) on their initial visit were evaluated for possible adverse statin effects (myalgia, fatigue, dyspnea, memory loss, and peripheral neuropathy). All patients discontinued statin therapy due to side effects and began supplemental CoQ(10) at an average of 240 mg/day upon initial visit. Patients have been followed for an average of 22 months with 84% of the patients followed now for more than 12 months. The prevalence of patient symptoms on initial visit and on most recent follow-up demonstrated a decrease in fatigue from 84% to 16%, myalgia from 64% to 6%, dyspnea from 58% to 12%, memory loss from 8% to 4% and peripheral neuropathy from 10% to 2%. There were two deaths from lung cancer and one death from aortic stenosis with no strokes or myocardial infarctions. Measurements of heart function either improved or remained stable in the majority of patients. We conclude that statin-related side effects, including statin cardiomyopathy, are far more common than previously published and are reversible with the combination of statin discontinuation and supplemental CoQ(10). We saw no adverse consequences from statin discontinuation.
Table S3 from Immunologic Characterization and T cell Receptor Repertoires of Expanded Tumor-infiltrating Lymphocytes in Patients with Renal Cell Carcinoma (2023)

&lt;p&gt;Supplementary Table S3 shows the sample availability, usage and TIL expansion potentials.&lt;/p&gt;
Understanding the inflammation-cancer transformation in the development of primary liver cancer (2018)

Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination and early diagnosis of hepatoma, complications of hepatoma, and their preventions and treatments, etc.
Improved sexual behavior in male rats treated with a Chinese herbal extract: hormonal and neuronal implications (2008)

The improvement in both appetitive and consummatory components of sexual behavior observed in male rats treated with the extract could be ascribed to increased serum T level in parallel with the activation of the central dopaminergic system.
A comparative study with feedforward pdp models for alphanumeric character recognition (1991)

Abstract This paper discusses the alphanumeric character recognition using two kinds of PDF (parallel distributed processing) models. The models considered are the FPM (fuzzy partition model) of a new type with multiple input/output units, and the conventional BP (back‐propagation) model. Two BP algorithms with different error evaluation functions are applied to those models, and the number of trainings and the recognition rate in the multifont recognition are compared. As a result of experiment, it is shown that FPM with Kullback divergence evaluation can realize a more accurate recognition with fever number of trainings, compared to the conventional BP model. The reason for the reduction of the number of trainings is discussed when the mutual inhibition in FPM unit as well as the Kullback divergence as the error evaluation function are employed.
Knowledge discovery from heterogeneous data streams using fourier spectrum of decision trees (2001)

The possibility of extracting knowledge from continuous flow-in data has gained significant attention lately. These data environments—often called data streams—include satellite images, financial data, Web logs, network traffic data, etc. Mining from data streams presents both practical and theoretical challenges. It is crucial to process data immediately as it flows in. However, data often stack up too fast to handle. In addition, since only a fraction of the data block is available within a particular time period, we need an elegant approach which properly aggregates all partial knowledge mined at different time frames. This dissertation proposes an ensemble model-based approach to mining knowledge from data streams. It considers decision trees and Fourier spectrum analysis to efficiently aggregate trees in an ensemble. In particular, it points out that representation of a decision tree in the Fourier basis has several useful properties that can be used to manipulate the trees. It offers algorithms to compute the Fourier spectrum of a decision tree and shows that multiple decision trees can be combined by simply adding up their respective spectrum. It also describes a new and novel technique to visualize a complex ensemble model at various resolutions using Fourier spectrum. 
Many time-critical applications like sensor networks and process control involve multiple data streams. So the ability to extract knowledge from multiple heterogeneous data streams is of paramount importance. Various heterogeneous sources are often scattered and data stack up fast Therefore, it is almost infeasible to apply any data mining algorithm that requires the centrally stored data. This dissertation attempts to mitigate the problem by employing a distributed data mining approach. It particularly builds a distributed decision tree model that can be learned with only modest amount of data exchange. This dissertation also describes basic requirements for an efficient, robust distributed data mining system and presents the BODHI as one such implementation.
Abstract P5-05-07: Expression of the cocaine- and amphetamine-regulated transcript (CART) recruits SWI/SNF chromatin remodelling complexes to the estrogen receptor (2019)

Abstract Introduction Cocaine- and amphetamine-regulated transcript (CART) peptides are neuropeptides involved in regulating physiological processes, such as feeding and drug reward. Recent studies have associated high CART expression with worse overall survival in patients with small-bowel carcinoid tumours and estrogen receptor-positive (ER+), lymph node-negative breast cancer. CART was also shown to be associated with poor patient response to tamoxifen, suggesting CART may play a role in conferring tamoxifen resistance. Materials and methods We have previously demonstrated that CART can impact the transcriptional activity of ERα through the use of western blotting and qPCR for specific ERα gene targets. RNA sequencing was carried out using a stable CART-inducible cell line model to identify genes which are upregulated/downregulated in cells expressing CART. Further, using our stable CART-inducible cell line model, we preformed ERα-Immunoprecipitation followed by in-solution mass spectrometry to identify differentially recruited protein complexes +/- CART expression. Results and discussion RNA sequencing revealed 156 significantly downregulated, and 100 significantly upregulated, genes in cells expressing CART (p&amp;lt;0.05). Through mining of publicly available ERα ChIP-seq data sets, both upregulated and downregulated gene sets were found to contain genes which have previously been shown to contain ERα binding events within their promotor regions. Mass spectrometry analysis revealed that the majority of proteins recruited to ERα in the presence of CART were members of the SWI/SNF (BAF) chromatin remodelling complex. The identification of SMARCD1 within this complex was of particular interest to this study, as this protein has previously been reported to be a critical mediator of nuclear receptor function. Further in silico analysis demonstrated high expression of SMARCD1 correlates with poor overall survival (OS) (p&amp;lt;0.00001) and distant metastasis free survival (DMFS) (p=0.00708) in a cohort of ER+ breast cancer patients. Intriguingly, SMARCD1 expression did not correlate with poor OS or DMFS in a cohort of ER- breast cancer patients, suggesting that this negative impact on survival is dependent on ER status. Conclusion In conclusion, we suggest that CART expression results in the recruitment of chromatin remodelling complexes to ERα in order to facilitate the regulation of receptor function and this impacts on patient outcome. Citation Format: O'Connor DP, Mooney B, Das S, Klinger R, Moran B, Ni Chonghaile T, Cagney G, Bracken A, Gallagher WM. Expression of the cocaine- and amphetamine-regulated transcript (CART) recruits SWI/SNF chromatin remodelling complexes to the estrogen receptor [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P5-05-07.
Studies of an Mre11 separation of function mutation give insight into the mechanism of double stranded DNA damage repair (2020)

The MRE11, RAD50, and NBS1 genes encode the proteins of the Mre11–Rad50–Nbs1 (MRN) complex, which is critical for proper maintenance of genomic integrity. The MRN complex acts in DNA double‐strand break repair (DSBR) detection, repair, and signaling. Exo‐ and endonuclease activities of Mre11 may regulate the choice between non‐homologous end‐joining (NHEJ) versus homologous recombination (HR) repair pathways but the exact mechanism is still nebulous. Two Mre11 mutations have been previously described as separation of function mutants: P. furiosus (Pf) H85S is both exo‐ and endonuclease inactive while Pf Mre11 H52S is exonuclease inactive but endonuclease active. Here we describe a new separation of function mutant: Pf Mre11 Y187C, which is also exonuclease inactive and endonuclease active. We have examined the possible causes for the difference in activities in Pf Mre11 Y187C and for the separation of function phenotype in general. Nuclear Magnetic Resonance (NMR) spectroscopy shows that both Y187C and H52S mutations alter the dynamic landscape of Mre11 affecting the DNA binding properties of the protein. We found that there is no change in binding of AMP (a nucleolytic product) by Y187C compared to WT. For DNA binding, Mre11ND constructs showed that Y187C binds both single and double stranded DNA with lower affinity than WT, but once Rad50 is added to the complex, there was no significant difference in affinity. Single site mutations in S. cerevisiae (yeast) established that the analogous Mre11 mutations are capable of DNA damage repair (i.e., survivability on plates with DNA‐damaging drugs), NHEJ repair, and DNA end resection, which is expected based on the previously described in vivo activity studies of MRN/X. Together, our data reveal that an aromatic group at amino acid position 187 in Pf Mre11 is important for nuclease activity, and our yeast data suggest that the presence of Mre11, but not it’s nuclease activity, is required for DSB repair in both repair pathways. Support or Funding Information Cancer Prevention and Research Institute of Texas (CPRIT) Y187C mutant is exonuclease inactive Figure 1 Affinity for dsDNA binding is lower with Y187C mutation Figure 2
High‐throughput simultaneous genotyping of human platelet antigen‐1 to ‐16 by using suspension array (2013)

Our method provides accurate, high-throughput, and simultaneous genotyping of HPA-1 to -16 and will serve as the foundation for large-scale clinical genotyping of HPAs and for the establishment of an HPA-typed PLT donor registry.
Utilization of Rice Bran Oil. X. (1962)

In the high pressure hydrogenation of high acid valued rice bran oil, authors appointed the optimum composition of unreduced Cu-Ni catalyst in industrial use. But the catalyst could not be useful in low pressure hydrogenation unless roasting. When there is 1.0% residue of extracting solvent trichloroethylene in oil, its catalytic poisonous action is less than that of formerly believed, but it has a good influence for bleaching and for the hydrogenating velocity regulation, in the high pressure hydrogenation. In the high pressure hydrogenation, up to 2.0% water content is not bad for results, but it is gradualy influenced from 2.0 to 8.0%, and the hydrolysis of fat is seen according with water content. The soapstock could not be hydrogenated by 1.0% nickel oxide catalyst. While, if recovered and then refined, it can be hydrogenated by unreduced Cu-Ni even 1.0% catalyst.
6 Een 65-jarige man met hevige pijn in de wijs- en middelvinger (2010)

Al jaren had deze 65-jarige man last van zijn wijs- en middelvinger: de proximale interfalangeale gewrichten deden pijn, vooral als hij werkzaamhedenmet zijn handen had verricht. Vaak waren de gewrichten warm en gezwollen. In de loop der jaren verminderde ook de functie van beide vingers. De mobiliteit nam steeds meer af en er ontstond een scheefstand van de vingertoppen naar ulnair. Ook de ringvinger vertoonde, zij het in mindere mate, dezelfde symptomen. Pijnstillers en ontstekingsremmende medicatie die hij van de huisarts kreeg, hielpen niet meer. Toen hij ook 's nachts pijn begon te krijgen en daardoor slecht sliep, besloot hij zijn huisarts nog eens te bezoeken. Deze verwees hem naar de orthopeed (FV).
A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca2+-signalling (2021)

Methods to assess neuronal receptor functions are needed in toxicology and for drug development. Human-based test systems that allow studies on glutamate signalling are still scarce. To address this issue, we developed and characterized pluripotent stem cell (PSC)-based neural cultures capable of forming a functional network. Starting from a stably proliferating neuroepithelial stem cell (NESC) population, we generate "mixed cortical cultures" (MCC) within 24 days. Characterization by immunocytochemistry, gene expression profiling and functional tests (multi-electrode arrays) showed that MCC contain various functional neurotransmitter receptors, and in particular, the N-methyl-D-aspartate subtype of ionotropic glutamate receptors (NMDA-R). As this important receptor is found neither on conventional neural cell lines nor on most stem cell-derived neurons, we focused here on the characterization of rapid glutamate-triggered Ca<sup>2+</sup> signalling. Changes of the intracellular free calcium ion concentration ([Ca<sup>2+</sup>]<sub>i</sub>) were measured by fluorescent imaging as the main endpoint, and a method to evaluate and quantify signals in hundreds of cells at the same time was developed. We observed responses to glutamate in the low µM range. MCC responded to kainate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and a subpopulation of 50% had functional NMDA-R. The receptor was modulated by Mg<sup>2+</sup>, Zn<sup>2+</sup> and Pb<sup>2+</sup> in the expected ways, and various toxicologically relevant agonists (quinolinic acid, ibotenic acid, domoic acid) triggered [Ca<sup>2+</sup>]<sub>i</sub> responses in MCC. Antagonists, such as phencyclidine, ketamine and dextromethorphan, were also readily identified. Thus, the MCC developed here may fill an important gap in the panel of test systems available to characterize the effects of chemicals on neurotransmitter receptors.
Lens-Loaded Coded Aperture with Increased Information Capacity for Computational Microwave Imaging (2020)

Computational imaging using coded apertures offers all-electronic operation with a substantially reduced hardware complexity for data acquisition. At the core of this technique is the single-pixel coded aperture modality, which produces spatio-temporarily varying, quasi-random bases to encode the back-scattered radar data replacing the conventional pixel-by-pixel raster scanning requirement of conventional imaging techniques. For a frequency-diverse computational imaging radar, the coded aperture is of significant importance, governing key imaging metrics such as the orthogonality of the information encoded from the scene as the frequency is swept, and hence the conditioning of the imaging problem, directly impacting the fidelity of the reconstructed images. In this paper, we present dielectric lens loading of coded apertures as an effective way to increase the information coding capacity of frequency-diverse antennas for computational imaging problems. We show that by lens loading the coded aperture for the presented imaging problem, the number of effective measurement modes can be increased by 32% while the conditioning of the imaging problem is improved by a factor of greater than two times.
Diversity of immunoglobulin heavy chain gene segment rearrangement in B lymphoblastoid cell lines from X‐linked agammaglobulinemia patients (1991)

X-linked agammaglobulinemia (XLA) is characterized by an arrest in early B lymphocyte differentiation. Precursor B cells are present in the bone marrow (BM), whereas peripheral blood B cell numbers are severely decreased. A series of Epstein-Barr virus (EBV)-transformed B lymphoblastoid cell lines (BLCL) was established from peripheral blood of three XLA patients belonging to one pedigree. These BLCL manifested productive VHDJH rearrangements and a random utilization of the VH families. The CDR3 regions of the rearrangements varied in length from 12 to 47 nucleotides and included N regions in all cases. The results supported the conclusion that the few B lymphocytes in peripheral blood of XLA patients exhibit all mechanisms that generate immunoglobulin (Ig) heavy (H) chain diversity. However, no evidence for somatic mutation was found. Within the VH3 family 50% of the expressed VH gene segments belonged to a single subgroup and within the VH4 family a preferential utilization of one VH4 gene element was observed. The utilization of H chain joining (HH) elements was biased to JH4 and JH6 and a high percentage of the CDR3 regions was found to be generated by unconventional mechanisms, such as multiple D usage and the fusion of D elements to D segments with irregular recombination recognition signals. These unique features of the recombined and expressed VHDJH regions in XLA may explain the inability of XLA patients to respond to a variety of antigens. Alternatively, they could be secondary to a B lymphocyte maturation defect in XLA.
Few-Mode Fiber for Uncoupled Mode-Division Multiplexing Transmissions (2011)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text P. Sillard, M. Bigot-Astruc, D. Boivin, H. Maerten, and L. Provost, "Few-Mode Fiber for Uncoupled Mode-Division Multiplexing Transmissions," in 37th European Conference and Exposition on Optical Communications, OSA Technical Digest (CD) (Optica Publishing Group, 2011), paper Tu.5.LeCervin.7. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article