gebhart/patrepeval huggingface dataset:
Bright Blue Solution Processed Triple‐Layer Polymer Light‐Emitting Diodes Realized by Thermal Layer Stabilization and Orthogonal Solvents (2013)

Abstract The realization of fully solution processed multilayer polymer light‐emitting diodes (PLEDs) constitutes the pivotal point to push PLED technology to its full potential. Herein, a fully solution processed triple‐layer PLED realized by combining two different deposition strategies is presented. The approach allows a successive deposition of more than two polymeric layers without extensively redissolving already present layers. For that purpose, a poly(9,9‐dioctyl‐fluorene‐co‐N‐(4‐butylphenyl)‐diphenylamine) (TFB) layer is stabilized by a hard‐bake process as hole transport layer on top of poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS). As emitting layer, a deep blue emitting pyrene‐triphenylamine copolymer is deposited from toluene solution. To complete the device assembly 9,9‐bis(3‐(5′,6′‐bis(4‐(polyethylene glycol)phenyl)‐[1,1′:4′,1″‐terphenyl]‐2′‐yl)propyl)‐9′,9′‐dioctyl‐2,7‐polyfluorene (PEGPF), a novel polyfluorene‐type polymer with polar sidechains, which acts as the electron transport layer, is deposited from methanol in an orthogonal solvent approach. Atomic force microscopy verifies that all deposited layers stay perfectly intact with respect to morphology and layer thickness upon multiple solvent treatments. Photoelectron spectroscopy reveals that the offsets of the respective frontier energy levels at the individual polymer interfaces lead to a charge carrier confinement in the emitting layer, thus enhancing the exciton formation probability in the device stack. The solution processed PLED‐stack exhibits bright blue light emission with a maximum luminance of 16 540 cd m −2 and a maximum device efficiency of 1.42 cd A −1 , which denotes a five‐fold increase compared to corresponding single‐layer devices and demonstrates the potential of the presented concept.
Scanning DMA Data Analysis I. Classification Transfer Function (2018)

The scanning electrical mobility spectrometer (SEMS; also known as the scanning mobility particle sizer, SMPS) enables rapid particle size distribution measurements with a differential mobility analyzer (DMA)/condensation particle counter (CPC) combination by ramping the classifier voltage, and continuously counting particles into time bins throughout the scan. Inversion of scanning measurements poses a challenge due to the finite time response of the CPC; the distorted data can be deconvoluted to improve the fidelity of size distributions obtained with the SEMS/SMPS. Idealized models of the classification region have shown that, for rapid voltage scans that approach the particle residence time in the DMA, the nondiffusive transfer function deviates from the symmetric one seen at constant voltage. Nonetheless, most SEMS/SMPS data analyses employ the constant voltage transfer function, a result that is valid only for plug flow in the classification region. This article develops the scanning-mode transfer function for the actual geometry of the TSI Model 3081 DMA. Finite element calculations are used to determine the flow and electric fields through the entire DMA. The instantaneous scanning-DMA transfer function for diffusive particles is determined using Brownian dynamics simulations. Comparisons of the results from this simulation of a real instrument to those from the idealized models reveal the shortcomings of prior models in describing the instantaneous scanning-DMA transfer function. A companion paper (Part II) combines this scanning-mode transfer function with response functions for the other components of a SEMS/SMPS measurement system in order to derive the response function for the integrated measurement system.Copyright © 2018 American Association for Aerosol Research
A Wide Range CMOS Power Amplifier with Improved Group Delay Variation and Gain Flatness for UWB Transmitters (2012)

This paper presents the design and implementation of 0.9-4.8GHz CMOS power amplifier (PA) with improved group delay variation and gain flatness at the same time for UWB transmitters. This PA design employs a two-stage cascade common source topology, a resistive shunt feedback technique and inductive peaking to achieve high gain flatness, and good input matching. Based on theoretical analysis, the main design factor for group delay variation is identified. The measurement results indicate that the proposed PA design has an average gain of 10.2 ± 0.8dB while maintaining a 3-dB bandwidth of 0.57 to 5.8GHz, an input return loss |S11| less than -4.4dB, and an output return loss |S22| less than -9.2dB over the frequency range of interest. The input 1dB compression point at 2GHz was -9dBm while consumes 30mW power from 1.5V supply voltage. Moreover, excellent phase linearity (i.e., group delay variation) of ±125ps was achieved across the whole band.
Risk of invasive cervical cancer associated with polymorphic HLA DR/DQ haplotypes (2002)

The genes encoding human leukocyte antigens (HLA) have shown to be associated with cervical neoplasia. To obtain reliable data on HLA associations with cervical tumors, the study should be performed within a strictly defined cohort. To investigate the population attributable risk of cervical cancer associated with the HLA class II haplotypes DR15 and DQ6 (DQA1*0102 and DQB1*0602), we performed a nested case-control study of 85 women who developed invasive cervical cancer and 120 healthy women from a population-based cohort of Swedish women. The relative risks of cervical cancer among DR15 and DQ6-positive women were 3.73 [confidence interval (CI): 1.8-7.4] and 4.33 (CI: 2.1-8.5), corresponding to population attributable proportions of 27.9% and 30.8%, respectively. A susceptibility locus in the HLA class II region is involved in a substantial fraction of the etiology of cervical cancer.
Genetic diagnosis of Mendelian disorders via RNA sequencing (2016)

Abstract Across a large variety of Mendelian disorders, ~50-75% of patients do not receive a genetic diagnosis by whole exome sequencing indicative of underlying disease-causing variants in non-coding regions. In contrast, whole genome sequencing facilitates the discovery of all genetic variants, but their sizeable number, coupled with a poor understanding of the non-coding genome, makes their prioritization challenging. Here, we demonstrate the power of transcriptome sequencing to provide a confirmed genetic diagnosis for 10% (5 of 48) of undiagnosed mitochondrial disease patients and identify strong candidate genes for patients remaining without diagnosis. We found a median of 1 aberrantly expressed gene, 5 aberrant splicing events, and 6 mono-allelically expressed rare variants in patient-derived fibroblasts and established disease-causing roles for each kind. Private exons often arose from sites that are weakly spliced in other individuals, providing an important clue for future variant prioritization. One such intronic exon-creating variant was found in three unrelated families in the complex I assembly factor TIMMDC1, which we consequently established as a novel disease-associated gene. In conclusion, our study expands the diagnostic tools for detecting non-exonic variants of Mendelian disorders and provides examples of intronic loss-of-function variants with pathological relevance.
Double-Sided Superior Vena Cava: Developmental Considerations Associated with the Thymic Veins (2022)

The superior vena cava is usually located only on the right side, but persistence of the left superior vena cavais observed in about 0.3 to 0.5 % of adults. A routine dissection of the cadaver of a 91-year-old Japanese female, whose cause of death was sepsis due to cholecystitis, was performed at Nagasaki University and revealed a double-sided superior vena cava. On the right side, the superior vena cava opened to the right atrium, while on the left, it opened into the extended coronary sinus. Veins in the left head, neck and upper limb regions joined to form the persistent left superior vena cava, with eventual drainage into the expanded coronary vein. An anastomosing branch occurred between each superior vena cava, and two thymic veins opened to the anastomosing branch. The azygos vein in the azygos venous system opened into the right superior vena cava, whereas a hemi-azygos vein opened into the azygos vein. The accessory hemi-azygos vein also opened into the azygos vein and opened cranially into the left superior vena cava. The left supreme intercostal vein also opened into the left superior vena cava. Several studies have reported a persistent left superior vena cava and the various considerations for its occurrence. Here, we propose a new hypothesis for the embryonic development of the persistent left superior vena cava with the thymic vein. This hypothesis essentially states that the left brachiocephalic vein fails to mature due to inadequate venous return from the thymic vein during the embryonic period, and the left superior vena cava then remains to maintain venous return from the left head, neck and upper limb. We also discuss the clinical significance of the persistent left superior vena cava.
Update on neurological paraneoplastic syndromes (2015)

The recognition of PNS is important for the early detection of an underlying malignancy and prompt initiation of therapies, which offers the best opportunity to stabilize or improve the neurological deficits and for those syndromes associated with cell surface antibodies usually results in substantial improvement or full recovery.
Effect of PLA crystallization on the structure of biomimetic composites of PLA and clay (2012)

Abstract Composites of poly(lactic acid) (PLA) and organoclays with clay loadings of up to 80% were prepared as self‐supporting films using a doctor‐blading approach. Depending on the properties of the used organoclay, either intercalated nanocomposites or conventional composites were obtained. The incorporation of such high amounts of clay resulted in up to 10‐fold decrease in the water vapor transmission rate when compared to the pristine polymer. The effect of clay platelets on the crystallization of PLA chains was also studied; it was found that high amounts of clay hinder only the melt crystallization of the polymer, whereas cold crystallization proceeds as usual. On the other hand, the crystallization of PLA also influenced the composite structure by increasing the extent of intercalation of polymer between clay layers. This study thus shows that the change in the extent of clay‐polymer interactions is also an important factor in controlling nanocomposite structure, especially for high loading. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
A New Steroidal Glycoside from Allium macrostemon Bunge (2018)

A phytochemical investigation of Allium macrostemon Bunge (Liliaceae) afforded the new pregnane steroidal glycoside, named allimacroside F (1), along with three known glycosides, benzyl-O-α-L-rhamnopy-ranosyl-(1 → 6)-β-D-glucopyranoside (2), phenylethyl-O-α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopyranoside (3), (Z)-3-hexenyl-O-α-L-rhamnopyranosyl-(1 →6)-β-D-glucopyranoside (4). The identification and structural elucidation of a new compound (1) was carried out based on spectral data analyses (1H-NMR,13C-NMR,1H–1H COSY, HSQC, HMBC, and NOESY) and HR-FAB-MS.
15-DEOXYSPERGUALIN FOR INDUCTION OF GRAFT NONREACTIVITY AFTER CARDIAC AND RENAL ALLOTRANSPLANTATION IN PRIMATES (1990)

In order to assess the immunosuppressive potentials of 15-deoxyspergualin (15-DS) in a preclinical experiment, heterotopic cardiac (n = 27, group I) and classic renal (n = 25, group II) allotransplantations were performed in Chacma baboons. The following immunosuppressive regimens were applied: Groups IB and IIB were treated with 15-DS alone (4 mg/kg/day) for p.o. days 0-9. Groups IC and IIC were treated with cyclosporine A (10-40 mg/kg/day) for p.o. days 0-30. Groups ID and IID received a combination of 15-DS (for p.o. days 0-9) and CsA (for p.o. days 0-30). Groups IA and IIA served as control and received no medication. The mean graft survival was 11.0 days for group IA, 28.2 days for group IB (P less than 0.05; IB vs. IA), 32.4 days for group IC, and 43.1 days for group ID (P less than 0.025; ID vs. IA). After renal transplantation, the corresponding figures were 12.3 days for group IIA, 8.5 days for group IIB, 30.4 days for group IIC and 148.9 days for group IID (P less than 0.025; IID vs. IIA). After cardiac and renal transplantation, acute rejection was the main cause of graft failure. Treatment-related side effects, mainly gastrointestinal complications, were observed only in primates, who were treated with 15-DS alone. After cardiac transplantation, permanent graft non-reactivity was not achieved, but a delayed rejection occurred within a mean of 21.8 days after immunosuppression had been stopped. Following renal transplantation, graft nonreactivity was also not achieved in groups IIB and IIC. In group IID, however, 4 of 8 animals (50%) were graft-tolerant 340, 256, 244, and 164 days after treatment discontinuation. Thus, the combination of 15-DS and CsA led to a significant prolongation of graft survival in both groups. Long-term nonreactivity was achieved only after renal transplantation, when initially treated with 15-DS and CsA.
Effect of Head Rotation at the Prone Position on the Geometric Features of the Healthy Carotid Bifurcation (2010)

The influence of posture change on the geometry and hemodynamics of the carotid bifurcation has not been thoroughly studied [1,2,3]. Such changes may alter the hemodynamic variables that are generally associated with the development of atherosclerosis, such as low oscillating wall shear stress (WSS) and particle residence times. Glor et al. (2004) had reported changes in the right carotid bifurcation geometry with leftward rotation of the head. We have previously reported that geometric differences in the right and left carotid bifurcation occur with a rightward rotation of the head [3].
Recrystallization rates and processes in laser-amorphized poly(ethylene terephthalate) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRecrystallization rates and processes in laser-amorphized poly(ethylene terephthalate)Philip D. Richards, Eric Weitz, A. J. Ouderkirk, and D. S. DunnCite this: Macromolecules 1993, 26, 6, 1254–1259Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/ma00058a009https://doi.org/10.1021/ma00058a009research-articleACS PublicationsRequest reuse permissionsArticle Views83Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Experiments in Robust Active Vibration Control Design for Slewing Flexible Structures (1999)

Abstract In this paper we present a hybrid Sliding Mode Control (SMC) and Constant Amplitude Feedback Control (CAFC) architecture for slewing flexible structures. The SMC controller is used to servo the flexible structure and the CAFC is used to suppress residual vibrations of the flexible structure. A single-axis encoder/DC motor/harmonic drive assembly is used for large angle slewing. A graphite/epoxy composite structure with embedded strain sensors/actuators is used for active vibration suppression. The results of this study include the analytical dynamic and control system development with experimental verification. The hybrid control algorithm uses the output sensor data from the encoder and strain sensor along with filters to derive velocity information to compute the control effort for the motor and strain actuators. Near-minimum time maneuvers based on an equivalent rigid structure are used to slew the flexible active structure. The tip mass was varied to evaluate control system robustness. Experimental slewing studies were performed to compare the benefits of using active rather than passive structures. For the active case the experimental results showed a reduction in residual vibration and settling time.
Superconducting anisotropy ofYNi2B2C (1995)

Torque magnetometry has been used to investigate anisotropy in the superconducting state of ${\mathrm{YNi}}_{2}$${\mathrm{B}}_{2}$C. The data indicate that the superconducting effective mass in this material is remarkably isotropic. On the basis of this result, it is argued that the homologous compound ${\mathrm{HoNi}}_{2}$${\mathrm{B}}_{2}$C provides an example of a material in which superconducting anisotropy results from layers of localized spins.
Faculty Opinions recommendation of Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design. (2005)

Bacillus anthracis secretes three polypeptides: protective antigen (PA), lethal factor (LF), and edema factor (EF), which interact at the surface of mammalian cells to form toxic complexes. LF and EF are enzymes that target substrates within the cytosol; PA provides a heptameric pore to facilitate LF and EF transport into the cytosol. Other than administration of antibiotics shortly after exposure, there is currently no approved effective treatment for inhalational anthrax. Here we demonstrate an approach to disabling the toxin: high-affinity blockage of the PA pore by a rationally designed low-molecular weight compound that prevents LF and EF entry into cells. Guided by the sevenfold symmetry and predominantly negative charge of the PA pore, we synthesized small cyclic molecules of sevenfold symmetry, beta-cyclodextrins chemically modified to add seven positive charges. By channel reconstitution and high-resolution conductance recording, we show that per-6-(3-aminopropylthio)-beta-cyclodextrin interacts strongly with the PA pore lumen, blocking PA-induced transport at subnanomolar concentrations (in 0.1 M KCl). The compound protected RAW 264.7 mouse macrophages from cytotoxicity of anthrax lethal toxin (= PA + LF). More importantly, it completely protected the highly susceptible Fischer F344 rats from lethal toxin. We anticipate that this approach will serve as the basis for a structure-directed drug discovery program to find new and effective treatments for anthrax. PMID: 16214885 Funding information This work was supported by: Intramural NIH HHS, United States NIAID NIH HHS, United States Grant ID: 1R43AI052894-01
Hop reservation multiple access (HRMA) for multichannel packet radio networks (2002)

A new multichannel MAC protocol called hop reservation multiple access (HRMA) for packet-radio networks is introduced, specified and analyzed. HRMA is based on very-slow frequency-hopping spread spectrum (FHSS) and takes advantage of the time slotting necessary for frequency hopping. HRMA allows a pair of communicating nodes to reserve a frequency hop (channel) using a hop reservation and handshake mechanism on every hop to guarantee collision-free data transmission in the presence of hidden terminals. HRMA provides a baseline to offer QoS in ad-hoc networks based on simple half-duplex slow FHSS radios. We analyze the throughput achieved in HRMA for the case of a fully-connected network assuming variable-length packets, and compare it against an ideal multichannel access protocol and the multichannel slotted ALOHA protocol. The numerical results show that HRMA can achieve much higher throughput than multichannel slotted ALOHA in the traffic-load ranges of interest especially when the average packet length is large compared to a slot size, in which case the maximum throughput of HRMA is close to what can be obtained with an ideal protocol.
Repeated Emergence of Variant TetR Family Regulator, FarR, and Increased Resistance to Antimicrobial Unsaturated Fatty Acid among Clonal Complex 5 Methicillin-Resistant Staphylococcus aureus (2023)

Resistance-nodulation-division (RND) superfamily efflux pumps promote antibiotic resistance in Gram-negative pathogens, but their role in Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) is undocumented. However, recent <i>in vitro</i> selections for resistance of S. aureus to an antimicrobial fatty acid, linoleic acid, and an antibiotic, rhodomyrtone, identified H121Y and C116R substitution variants, respectively, in a TetR family regulator, FarR, promoting increased expression of the RND pump FarE. Hypothesizing that <i>in vivo</i> selection pressures have also promoted the emergence of FarR variants, we searched available genome data and found that strains with FarR<sup>H121Y</sup> from human and bovine hosts have emerged sporadically in clonal complexes (CCs) CC1, CC30, CC8, CC22, and CC97, whereas multiple FarR variants have occurred within CC5 hospital-associated (HA)-MRSA. Of these, FarR<sup>E160G</sup> and FarR<sup>E93EE</sup> were exclusive to CC5, while FarR<sup>C116Y</sup>, FarR<sup>P165L</sup>, and FarR<sup>G166D</sup> also occurred in nonrelated CCs, primarily from bovine hosts. Within CC5, FarR<sup>C116Y</sup> and FarR<sup>G166D</sup> strains were polyphyletic, each exhibiting two emergence events. FarR<sup>C116Y</sup> and FarR<sup>E160G</sup> were individually sufficient to confer increased expression of FarE and enhanced resistance to linoleic acid (LA). Isolates with FarR<sup>E93EE</sup> were most closely related to S. aureus N315 MRSA and exhibited increased resistance independently of FarR<sup>E93EE</sup>. Accumulation of pseudogenes and additional polymorphisms in FarR<sup>E93EE</sup> strains contributed to a multiresistance phenotype which included fosfomycin and fusidic acid resistance in addition to increased linoleic acid resistance. These findings underscore the remarkable adaptive capacity of CC5 MRSA, which includes the polyphyletic USA100 lineage of HA-MRSA that is endemic in the Western hemisphere and known for the acquisition of multiple resistance phenotypes.
Deep high-dose erbium implantation of low-loss siliconoxynitride waveguides (1994)

Photoluminescence studies of low-loss SiON waveguides deeply (2.8 MeV) implanted with erbium at concentrations up to 1 atm.% are reported. Rapid thermal annealing at 900°C is found to repair most of the implantation damage and results in a 5.3 ms 4I13/2 lifetime for 0.25 atm.% Er concentration. Measurements in 1 atm.% doped samples show significant erbium ion-ion interactions.