gebhart/patrepeval huggingface dataset:
A selective low induced damage ICP dry etching process for a self-aligned InP-InGaAs HBT technology (2003)

We report on an inductively coupled plasma (ICP) process using CH/sub 4//H/sub 2//O/sub 2/ chemistry which have been studied for a self-aligned HBT technology. A very low bias voltage is used to reduce the induced damages. The study has concerned the ion flux characteristics: ion current and ion energy. Surface morphology, pattern profile, etch rates and induced damages were investigated as functions of ion energy and density for an optimized ICP reactor configuration. A comparison is made with an ICP process using a SiCl/sub 4/ chemistry. Finally, a selective process allowing one to attempt an almost full dry etching self-aligned process for HBT applications is described.
Reliable estimation of heart surface motion under stochastic and unknown but bounded systematic uncertainties (2010)

A reliable estimation of heart surface motion is an important prerequisite for the synchronization of surgical instruments in robotic beating heart surgery. In general, only an imprecise description of the heart dynamics and measurement systems is available. This means that the estimation of heart motion is corrupted by stochastic and systematic uncertainties. Without consideration of these uncertainties, the obtained results will be inaccurate and a safe robotic operation cannot be guaranteed. Until now, existing approaches for estimating the motion of the heart surface are either deterministic or treat only stochastic uncertainties. The proposed method extends the heart motion estimation to the simultaneous consideration of stochastic and unknown but bounded systematic uncertainties. It computes dynamic bounds in order to provide the surgeon with a guidance by constraining the motion of the surgical instruments and thereby protecting sensitive tissue.
Unanimity in an unknown and unreliable environment (1981)

Can unanimity be achieved in an unknown and unreliable distributed system? We analyze two extreme models of networks: one in which all the routes of communication are known, and the other in which not even the topology of the network is known. We prove that independently of the model, unanimity is achievable if and only if the number of faulty processors in the system is 1. less than one half of the connectivity of the system's network, and 2. less than one third of the total number of processors. In cases where unanimity is achievable, an algorithm to obtain it is given.
Algorithm 297: Eigenvalues and Eigenvectors of the symmetric system (1967)

p r o c e d u r e eigensolve (a, b, x, n, nondef); value n; i n t e g e r n; l a b e l nondef; a r r a y a, b, x; c o m m e n t solves the equation (A --XB)X = 0 for symmetric A, B in a, b[1 :n, l:n] provided one of these is either positive or negative-definite. B is decomposed symmetrically so that B = LL' and the equation transformed to (C--X/)Y = 0 where
Design of a low voltage folded waveguide four beam Mini-TWT (2018)

Folded Waveguide (FW)mini-TWT based on four beams operating at 6.2 kV with total beam power 2.7 kW has been designed by using NRL design codes. The FW slow wave structure (SWS) has been fabricated and "cold" tested. The results of measurements are compared with design. The status of experimental demonstration of the mini- TWT will be presented.
Current and speed sensor FDIR for a DFIM grid connected variable speed pumped storage system (2017)

This paper proposes Fault Detection, Isolation and Reconfiguration (FDIR) techniques to realize the connection of a DFIM pumped storage system with the grid in the presence of current and speed sensor failures. For the detection method authors use the parity space approach either for current sensor failure or the rotation speed one. The proposed reconfiguration techniques exploit stator flux estimation using existing stator current and voltage measurements. All studied system (DFIM pumped storage and grid) with proposed FDIR strategy is simulated using PSIM software. Next, simulations and experimental results are given to validate the synchronization phase in healthy conditions and to demonstrate the effectiveness of the proposed detection method to isolate the faulty sensor and to guarantee the satisfactory behavior of this system.
Suppression of 14-3-3γ-mediated surface expression of ANO1 inhibits cancer progression of glioblastoma cells (2016)

Anoctamin-1 (ANO1) acts as a Ca(2+)-activated Cl(-) channel in various normal tissues, and its expression is increased in several different types of cancer. Therefore, understanding the regulation of ANO1 surface expression is important for determining its physiological and pathophysiological functions. However, the trafficking mechanism of ANO1 remains elusive. Here, we report that segment a (N-terminal 116 amino acids) of ANO1 is crucial for its surface expression, and we identified 14-3-3γ as a binding partner for anterograde trafficking using yeast two-hybrid screening. The surface expression of ANO1 was enhanced by 14-3-3γ, and the Thr9 residue of ANO1 was critical for its interaction with 14-3-3γ. Gene silencing of 14-3-3γ and/or ANO1 demonstrated that suppression of ANO1 surface expression inhibited migration and invasion of glioblastoma cells. These findings provide novel therapeutic implications for glioblastomas, which are associated with poor prognosis.
Increasing ESP Lifetime by Employing Novel Non-Corrosive Acid System for Scales Removal (2022)

Abstract The scales precipitated on the electric submersible pump (ESP) will lead to trapped heat, lower the motor's cooling capacity, decrease the pump lifetime, and finally pump failure. Removal of oil field scales commonly requires low pH acid that can cause corrosion, hydrogen sulfide evolution, ferric and ferrous hydroxide precipitation, iron sulfide as a by-product, and/or sulfur precipitation. Scales typically occur in the near wellbore, tubing, downhole pumps, and surface equipment. A mineral deposition is widespread with a change in pressure, temperature, pH, and incompatible mixing between injected seawater and formation water. This paper presents a new scale dissolver that is non-corrosive and has a high scale dissolution performance for barium sulfate scales. The study explains a series of comprehensive experimental lab tests such as X-ray diffraction (XRD), X-ray fluorescence (XRF), brine compositional analysis, fluid compatibility and stability, solubility test, precipitation tendency for the dissolved solids, and corrosion test to evaluate and simulate the field application of the new dissolver using two field scale types that mainly contain barium sulfate (BaSo4) scales. The obtained successful results indicated that the novel dissolver had a great dissolution efficiency for two real barium scale samples as the results showed that the dissolution rate recorded 91.3 and 78.4 % at 90 °C for samples 1 and 2 respectively. The novel dissolver showed a very low precipitation tendency for the scale dissolved solids (1.9 and 3.2 % for samples 1 and 2 respectively). Without any additives of corrosion inhibitors, the corrosion rate was 0.00376 lb/ft2 at 1000 psi and 50 °C for 6 hours. The obtained successful results will help to dissolve the barium sulfate scales, maintain the ESP performance, increase the lifetime, and save extra cost for the pump operational problems due to scale precipitations.
Is early-onset primary Sjögren’s syndrome a worse prognosis form of the disease? (2018)

Onset of primary SS is usually between 40 and 60 years of age, with severe systemic complications in 15% of cases. We sought to determine whether early-onset disease is related to a specific phenotype and if it is predictive of a poor outcome. Biological and clinical data from 393 patients recruited in the ASSESS cohort, a French multicentre prospective cohort, were compared according to age at diagnosis. Fifty-five patients had early-onset disease, defined as age ⩽35 years at diagnosis, and presented a significantly higher frequency of salivary gland enlargement (47.2% vs 33.3%, P = 0.045), adenopathy (25.5% vs 11.8%, P = 0.006), purpura (23.6% vs 9.2%, P = 0.002) and renal involvement (16.4% vs 4.4%, P = 0.003). They had a higher frequency of hypergammaglobulinaemia (60.8% vs 26.6%, P < 0.001), RF positivity (41.5% vs 20.2%, P < 0.001), low C3 level (18.9% vs 9.1%, P = 0.032), low C4 level (54.7% vs 40.2%, P = 0.048) and autoantibodies [84.6% with anti-SSA vs 54.4% (P < 0.001) and 57.7% with anti-SSB vs 29.7% (P < 0.001)]. The change in ESSDAI scores between baseline and the 5-year follow-up was significantly different (P = 0.005) with a trend for worsening in the early-onset group (0.72, P = 0.27) and a significant improvement in the later onset group (−1.27, P < 0.0001). Early-onset primary SS is associated with a specific phenotype defined by clinical and biological features known to be predictive factors of severe systemic disease. Interestingly, we showed a different evolution of the ESSDAI score depending on the age at disease onset, patients with early-onset disease tending to worsen over time.
Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice (2012)

Although cancer tends to affect the elderly, most preclinical studies are carried out in young subjects. In this study, we developed a melanoma-specific cancer immunotherapy that shows efficacy in aged but not young hosts by mitigating age-specific tumor-associated immune dysfunction. Both young and aged CD4(+)CD25(hi) regulatory T cells (Treg) exhibited equivalent in vitro T-cell suppression and tumor-associated augmentation in numbers. However, denileukin diftitox (DT)-mediated Treg depletion improved tumor-specific immunity and was clinically effective only in young mice. DT-mediated Treg depletion significantly increased myeloid-derived suppressor cell (MDSC) numbers in aged but not young mice, and MDSC depletion improved tumor-specific immunity and reduced tumor growth in aged mice. Combining Treg depletion with anti-Gr-1 antibody was immunologically and clinically more efficacious than anti-Gr-1 antibody alone in aged B16-bearing mice, similar to Treg depletion alone in young mice. In contrast, DT increased MDSCs in young and aged mice following MC-38 tumor challenge, although effects were greater in aged mice. Anti-Gr-1 boosted DT effects in young but not aged mice. Aged antitumor immune effector cells are therefore competent to combat tumor when underlying tumor-associated immune dysfunction is appropriately mitigated, but this dysfunction varies with tumor, thus also varying responses to immunotherapy. By tailoring immunotherapy to account for age-related tumor-associated immune dysfunctions, cancer immunotherapy for aged patients with specific tumors can be remarkably improved.
Use of Penicillin-binding Proteins for the Identification of Enterococci (1986)

The results of 20 physiological and fermentation tests and examination of the penicillin-binding proteins (PBPs) of 85 enterococcal strains demonstrated that the genus Enterococcus could be divided into at least nine distinct species: E. faecalis, E. faecium, E. durans, E. hirae, E. avium, E. gallinarum, E. casseliflavus, E. malodoratus and E. mundtii. Each species had a specific pattern of at least five PBPs, with molecular masses in the range of about 40-130 kDa. The pattern of PBPs may be useful for identification purposes, since some strains with unusual fermentation characteristics were assigned to species by this technique.
Spectroscopic Elucidation of the Repassivation of Active Sites on Aluminum by Chromate Conversion Coating (2004)

It has long been hypothesized and recently shown that hexavalent chromium ions in the chromate conversion coating (CCC) migrate to active sites. This repassivation behavior of chromate conversion coatings leads to protection from corrosion resulting from mechanical damage. The nature of this repassivation has been explored here using Raman spectroscopy and synchrotron X-ray absorption near-edge structure (XANES) spectroscopy. Raman spectroscopic analysis of a mechanically damaged area on the CCC supports the theory of chromium ion migration and formation of an Al(III)-Cr(VI) complex at the active sites. Results of an investigation performed using XANES corroborate the formation of the complex at active sites such as pits/valleys/scratches even under other chromating conditions. This study therefore provides unambiguous evidence for the theory of migration of chromates. © 2004 The Electrochemical Society. All rights reserved.
Primary Rhabdomyosarcoma of the Central Nervous System: Case Report (1985)

A case of a primary rhabdomyosarcoma that appeared to be arising from the filum terminale in a 48-year-old man is reported. The histological diagnosis of rhabdomyosarcoma was supported using immunocytochemical methods. Twenty-two cases of primary rhabdomyosarcoma of the central nervous system previously reported in the literature are reviewed briefly. The possible origin of these tumors from neuroectoderm is discussed.
Dependence of Soluble Guanylyl Cyclase Activity on Calcium Signaling in Pituitary Cells (2001)

The role of nitric oxide (NO) in the stimulation of soluble guanylyl cyclase (sGC) is well established, but the mechanism by which the enzyme is inactivated during the prolonged NO stimulation has not been characterized. In this paper we studied the interactions between NO and intracellular Ca(2+) in the control of sGC in rat anterior pituitary cells. Experiments were done in cultured cells, which expressed neuronal and endothelial NO synthases, and in cells with elevated NO levels induced by the expression of inducible NO synthase and by the addition of several NO donors. Basal sGC-dependent cGMP production was stimulated by the increase in NO levels in a time-dependent manner. In contrast, depolarization of cells by high K(+) and Bay K 8644, an L-type Ca(2+) channel agonist, inhibited sGC activity. Depolarization-induced down-regulation of sGC activity was also observed in cells with inhibited cGMP-dependent phosphodiesterases but not in cells bathed in Ca(2+)-deficient medium. This inhibition was independent from the pattern of Ca(2+) signaling (oscillatory versus nonoscillatory) and NO levels, and was determined by averaged concentration of intracellular Ca(2+). These results indicate that inactivation of sGC by intracellular Ca(2+) serves as a negative feedback to break the stimulatory action of NO on enzyme activity in intact pituitary cells.
A Study of the Scalability of On-Chip Routing for Just-in-Time FPGA Compilation (2005)

Just-in-time (JIT) compilation has been used in many applications to enable standard software binaries to execute on different underlying processor architectures. We previously introduced the concept of a standard hardware binary, using a just-in-time compiler to compile the hardware binary to a field-programmable gate array (FPGA). Our JIT compiler includes lean versions of technology mapping, placement, and routing algorithms, of which routing is the most computationally and memory expensive step. As FPGAs continue to increase in size, a JIT FPGA compiler must be capable of efficiently mapping increasingly larger hardware circuits. In this paper, we analyze the scalability of our lean on-chip router, the Riverside on-chip router (ROCR), for routing increasingly large hardware circuits. We demonstrate that ROCR scales well in terms of execution time, memory usage and circuit quality, and we compare the scalability of ROCR to the well known versatile place and route (VPR) timing-driven routing algorithm, comparing to both their standard routing algorithm and their fast routing algorithm. Our results show that on average ROCR executes 3 times faster using 18 times less memory than VPR. ROCR requires only 1% more routing resources, while creating a critical path 30% longer VPR's standard timing-driven router. Furthermore, for the largest hardware circuit, ROCR executes 3 times faster using 14 times less memory, and results in a critical path 2.6% shorter than VPR's fast timing-driven router.
Carnitine and experimental carbohydrate-induced hyperlipoproteinemia. (1987)

Carnitine, beta-hydroxy-gamma-trimethylaminobutyrate, plays an important role as a factor necessary for the transport of long-chain fatty acids into the mitochondria. In order to investigate the influence of L(--)-carnitine on hyperlipoproteinemias, the experimental model of the sucrose-induced hypertriglyceridemia of the rat was used. In these experiments L(--)-carnitine in the dose of 11 mg per day and 100 g body weight was able to antagonize the sucrose-induced hypertriglyceridemia and the increase of serum-free fatty acid level in female rats of the Wistar strain. Carnitine administration did not change the activities of lipogenic liver enzymes and the activity of post-heparin lipase. On the other hand, carnitine administration increased the rate of fatty acid oxidation in the liver. The main result of the study, i.e. the lipid-lowering effect of L-carnitine, suggests the use of this compound in the therapy of hyperlipoproteinemias.
Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library (2021)

We performed in vitro selection experiments to identify DNA aptamers for the S1 subunit of the SARS-CoV-2 spike protein (S1 protein). Using a pool of pre-structured random DNA sequences, we obtained over 100 candidate aptamers after 13 cycles of enrichment under progressively more stringent selection pressure. The top 10 sequences all exhibited strong binding to the S1 protein. Two aptamers, named MSA1 (Kd = 1.8 nM) and MSA5 (Kd = 2.7 nM), were assessed for binding to the heat-treated S1 protein, untreated S1 protein spiked into 50% human saliva and the trimeric spike protein of both the wildtype and the B.1.1.7 variant, demonstrating comparable affinities in all cases. MSA1 and MSA5 also recognized the pseudotyped lentivirus of SARS-CoV-2 with respective Kd values of 22.7 pM and 11.8 pM. Secondary structure prediction and sequence truncation experiments revealed that both MSA1 and MSA5 adopted a hairpin structure, which was the motif pre-designed into the original library. A colorimetric sandwich assay was developed using MSA1 as both the recognition element and detection element, which was capable of detecting the pseudotyped lentivirus in 50% saliva with a limit of detection of 400 fM, confirming the potential of these aptamers as diagnostic tools for COVID-19 detection.
Polycaprolactam filled with short glass fibres and microbeads. II. Elastic and ultimate properties of composites prepared by the anionic adiabatic polymerization (1985)

Abstract The rigidity of composites of alkali polycaprolactam was found to be in good agreement with theoretical prediction. A decrease in tensile strength with the concentration of fibres was due to the fact that a large fraction of incorporated fibres was of subcritical length and that polycaprolactam polymerized in presence of fillers had a lower molecular weight and crystallinity and contained smaller spherulites. The supposed increase in impact strength occurred at volume fractions of fibres above 0.14.
Intrinsically disordered regions that drive phase separation form a robustly distinct protein class (2022)

Abstract Liquid-liquid phase separation (LLPS) of proteins is thought to be a primary driving force for the formation of membraneless organelles, which control a wide range of biological functions from stress response to ribosome biogenesis. LLPS of proteins in cells is primarily, though not exclusively, driven by intrinsically disordered (ID) domains. Accurate identification of ID regions (IDRs) that drive phase separation is important for testing the underlying mechanisms of phase separation, identifying biological processes that rely on phase separation, and designing sequences that modulate phase separation. To identify IDRs that drive phase separation, we first curated datasets of folded, ID, and phase-separating (PS) ID sequences. We then used these sequence sets to examine how broadly existing amino acids scales can be used to distinguish between the three classes of protein regions. We found that there are robust property differences between the classes and, consequently, that numerous combinations of amino acid property scales can be used to make robust predictions of LLPS. This result indicates that multiple, redundant mechanisms contribute to the formation of phase-separated droplets from IDRs. The top-performing scales were used to further optimize our previously developed predictor of PS IDRs, ParSe. We then modified ParSe to account for interactions between amino acids and obtained reasonable predictive power for mutations that have been designed to test the role of amino acid interactions in driving LLPS.
Improving prediction performance of colon cancer prognosis based on the integration of clinical and multi-omics data (2020)

In conclusion, this study successfully combined clinical and multi-omics data for better prediction of colon cancer prognosis.
Allyl Sulfoxides as Precursors for Radical Two‐Carbon Ring Expansion of Cyclobutanones. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Reference intervals for feline cerebrospinal fluid: Cell counts and cytologic features (1990)

Reference intervals for feline CSF cell counts and cytologic variables were determined. Values were derived from 58 adult cats that had normal neurologic examination findings and did not have histologic lesions of the CNS. Effect of age or gender was not apparent for any CSF variable, and no CSF variable was significantly correlated with its corresponding blood value. Total WBC count and neutrophil and eosinophil percentages were positively correlated with the CSF RBC count. Thus, proposed reference intervals for feline CSF were derived from 33 cats with CSF RBC count of less than 31 cells/ul. Data for CSF samples with range between 31 and 1,700 RBC/microliters were also determined. Erythrocyte count was not significantly different in CSF collected, using 20- or 22-gauge spinal needles.
You are What you Eat (and Drink): Identifying Cultural Boundaries by Analyzing Food & Drink Habits in Foursquare (2014)

Food and drink are two of the most basic needs of human beings. However, as society evolved, food and drink became also a strong cultural aspect, being able to describe strong differences among people. Traditional methods used to analyze cross-cultural differences are mainly based on surveys and, for this reason, they are very difficult to represent a significant statistical sample at a global scale. In this paper, we propose a new methodology to identify cultural boundaries and similarities across populations at different scales based on the analysis of Foursquare check-ins. This approach might be useful not only for economic purposes, but also to support existing and novel marketing and social applications. Our methodology consists of the following steps. First, we map food and drink related check-ins extracted from Foursquare into users' cultural preferences. Second, we identify particular individual preferences, such as the taste for a certain type of food or drink, e.g., pizza or sake, as well as temporal habits, such as the time and day of the week when an individual goes to a restaurant or a bar. Third, we show how to analyze this information to assess the cultural distance between two countries, cities or even areas of a city. Fourth, we apply a simple clustering technique, using this cultural distance measure, to draw cultural boundaries across countries, cities and regions.