gebhart/patrepeval huggingface dataset:
Rapid isolation of vitexin from leaves of kinkeliba, Combretum micranthum G. Don (2021)

Vitexin, the main flavonoid was extracted from the leaves of Combretum micranthum in soxhlet with ethanol. The extract evaporated to dryness and retrieved thanks to hot water. That liquid extract went through a degreasing and extracted again with butanol. The butanolic extract evaporated to dryness and dissolved in methanol, in which the vitexin precipitated after the washing and the recrystallisation of the first obtained precipitate. From 500g of dry kinkeliba leaves, a series of manipulations led to the isolation of 0.0576 g of vitexin, yielding 0.013% per ounce of the kinkeliba leaves dry powder. The degree of purity of vitexin was 94.79% on the basis of HPLC/UV-Vis/MS of the chemical formula C21H20O10. According to the spectral data NMR 1H and 13C the molecular structure of the vitexin is identified.
ChemInform Abstract: Computer‐Assisted Synthetic Analysis. Quantitative Assessment of Transform Utilities. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High Fidelity Face Manipulation with Extreme Poses and Expressions (2019)

Face manipulation has shown remarkable advances with the flourish of Generative Adversarial Networks. However, due to the difficulties of controlling structures and textures, it is challenging to model poses and expressions simultaneously, especially for the extreme manipulation at high-resolution. In this paper, we propose a novel framework that simplifies face manipulation into two correlated stages: a boundary prediction stage and a disentangled face synthesis stage. The first stage models poses and expressions jointly via boundary images. Specifically, a conditional encoder-decoder network is employed to predict the boundary image of the target face in a semi-supervised way. Pose and expression estimators are introduced to improve the prediction performance. In the second stage, the predicted boundary image and the input face image are encoded into the structure and the texture latent space by two encoder networks, respectively. A proxy network and a feature threshold loss are further imposed to disentangle the latent space. Furthermore, due to the lack of high-resolution face manipulation databases to verify the effectiveness of our method, we collect a new high-quality Multi-View Face (MVF-HQ) database. It contains 120,283 images at 6000x4000 resolution from 479 identities with diverse poses, expressions, and illuminations. MVF-HQ is much larger in scale and much higher in resolution than publicly available high-resolution face manipulation databases. We will release MVF-HQ soon to push forward the advance of face manipulation. Qualitative and quantitative experiments on four databases show that our method dramatically improves the synthesis quality.
Radiographic evaluation of frontal talar edge configuration for osteochondral plug transplantation (2008)

For successful reconstruction of osteochondral lesions of the talus, the anatomic configuration of the talar edge must be respected. This study evaluated the radiographic configuration of the talar edge in the anterior-posterior (AP) view by analyzing medial and lateral talar edge angles and radii in 81 patients with a true AP view and without ankle pathology. The mean lateral talar edge angle was 91.8 degrees , and the mean medial talar edge angle was 110.0 degrees . The medial frontal talar edge radius was 4.8 mm and the lateral 3.5 mm, respectively. No correlation between angle and radius was found. These results revealed a significant difference between the medial and the lateral talar edge configuration. This may be due to the three-dimensional function of the human ankle joint. No study so far has addressed these differences radiologically. These differences should be addressed in the reconstruction of osteochondral lesions and be included in the preoperative planning.
CORROSION INHIBITION OF CASEIN AS A NATURAL PROTEIN FOR 316L STAINLESS STEEL IN SIMULATED BODY FLUID (2020)

The importance of biomaterials is increased steadily with the augmentation of population and aging. In this research, casein, a protein present in milk, used to modify the 316L stainless steel (316L SS) alloy surface, used in medical application, against corrosion in the corrosive body fluid. Due to the presence of hetero-atoms in its moiety, casein has the ability to form a protective thin layer. Self-assembled monolayers (SAMs) technique is a common tool providing a well ordered thin film on the metallic surface. Casein was assumed to form SAMs on the 316L SS surface and the corrosion inhibition efficiency was examined electrochemically. The results proved the formation of SAMs and displayed that casein reduce the corrosion rate and serves as a mixed type inhibitor. The inhibition efficiency is increased by increasing the casein’s concentration and immersion time in the casein’s solution. A maximum inhibition efficiency obtained at 1000 ppm with immersion time equals 120 minutes. Further modification is undertaken to increase the inhibition efficiency.
Understanding the Challenges and Uncertainties of Seroprevalence Studies for SARS-CoV-2 (2021)

SARS-CoV-2 continues to widely circulate in populations globally. Underdetection is acknowledged and is problematic when attempting to capture the true prevalence. Seroprevalence studies, where blood samples from a population sample are tested for SARS-CoV-2 antibodies that react to the SARS-CoV-2 virus, are a common method for estimating the proportion of people previously infected with the virus in a given population. However, obtaining reliable estimates from seroprevalence studies is challenging for a number of reasons, and the uncertainty in the results is often overlooked by scientists, policy makers, and the media. This paper reviews the methodological issues that arise in designing these studies, and the main sources of uncertainty that affect the results. We discuss the choice of study population, recruitment of subjects, uncertainty surrounding the accuracy of antibody tests, and the relationship between antibodies and infection over time. Understanding these issues can help the reader to interpret and critically evaluate the results of seroprevalence studies.
Coopetition Against an Amazon (2023)

This paper analyzes cooperative data-sharing between competitors vying to predict a consumer's tastes. We design optimal data-sharing schemes both for when they compete only with each other, and for when they additionally compete with an Amazon – a company with more, better data. We show that simple schemes – threshold rules that probabilistically induce either full data-sharing between competitors, or the full transfer of data from one competitor to another – are either optimal or approximately optimal, depending on properties of the information structure. We also provide conditions under which firms share more data when they face stronger outside competition, and describe situations in which this conclusion is reversed.
Design of a peptibody consisting of the antimicrobial peptide dhvar5 and a llama variable heavy-chain antibody fragment (2006)

Immunoconjugates have been widely studied as potential therapeutics for infectious diseases to direct unspecific antimicrobials to pathogens. In this study, the recombinant approach was used for expression of the immunoconjugate composed of the variable domain of a llama heavy-chain antibody (VHH) against Streptococcus mutans and dhvar5, a synthetic antimicrobial peptide. Before cloning, the impact of the elongation of the peptide termini on its biological activity was evaluated by chemical synthesis of the N- or C-termini extended dhvar5 peptides. As the elongation of the C-terminus had a greater influence on decline of the antimicrobial activity, the N-terminal fusion was designed. To promote in vivo release of the active peptide, a factor Xa cleavage site was inserted between VHH and dhvar5. Propagation of transformed Escherichia coli with the constructed plasmid was only possible in the absence of isopropyl beta-D-thiogalactoside (IPTG). Although these data demonstrate that the diminished antimicrobial activity of dhvar5 by the N-terminal fusion to VHH was not sufficient for the protection of the bacterial host cells against the peptide lethal effect, an insight into propeptides biological activities may be beneficial not only for new and more successful rearrangement of the VHH-dhvar5 immunoconjugate construct, but also design of the other recombinant molecules composed of peptides toxic to host cells.
Phase 1/2 Study of AMG 531 in Thrombocytopenic Patients (pts) with Low-Risk Myelodysplastic Syndrome (MDS): Update Including Extended Treatment. (2007)

Abstract Background: AMG 531 is a novel thrombopoiesis-stimulating peptibody that is being studied for its ability to increase platelet production by stimulating the thrombopoietin receptor. This report updates outcomes in Part A of the study as of May 2007 on pts who continued into the extension phase of this ongoing phase 1/2, open-label, sequential-cohort, dose-escalation study to evaluate the safety and efficacy of AMG 531 in low risk MDS pts with severe thrombocytopenia (Kantarjian et al., ASCO, 2007). Methods: Pts with low- risk MDS (IPSS Low or Intermediate-1, excluding CMML), a mean baseline platelet count ≤50×109/L, and only receiving supportive care were eligible to enter this study. Pts were enrolled into sequential cohorts of 300, 700, 1000, and 1500μg, receiving 3 weekly subcutaneous injections of AMG 531. After evaluation of platelet response at week 4, pts could continue AMG 531 in an optional treatment extension at their assigned dose or dose adjust to achieve or maintain a response. Results: The mean duration of exposure to AMG 531 was 23±15.5 (SD) weeks. Of 44 pts enrolled, 40 continued into the extension phase; 16 pts remain on treatment. Eighteen pts (41%) achieved a durable platelet response (per IWG 2006 criteria for at least 8 consecutive weeks). Evaluation of durable responses based on baseline platelet count showed that responses occurred in 12/29 (41%) pts with a baseline count of ≥20×109/L, and in 6/15 (40%) pts with a baseline count of &amp;lt;20×109/L. The mean duration of the platelet response was 22.8±13.3 (SD) weeks. A total of 104 platelet transfusions were given to 17/44 (39%) pts during this study; of these transfusions, 7 were given in 3/18 (17%) pts who achieved a durable response. Treatment-related AEs were reported in 17 pts. There were 3 deaths unrelated to treatment. Two confirmed cases of transformation to AML were reported. These two pts received maximum doses of 300 and 1000μg. Six pts were confirmed to have temporary blast cell increases, three of whom had increases above 20%. Of the 6, 4 were receiving 1500μg and 2 were receiving 1000μg. In all 6 pts, blast cell counts were observed to have fallen upon follow-up assessments within 7 weeks after treatment discontinuation. In one case, treatment was reinitiated at 700μg. Conclusions: In this study, AMG 531 appeared to be well-tolerated in severely thrombocytopenic low-risk MDS pts, and resulted in increased and sustained platelet counts in the responding pts. AMG 531 may have a role in the treatment of low-risk MDS pts who are thrombocytopenic or have a history of bleeding. These data suggest that further exploration is merited in this pt population. Pt recruitment is ongoing until reaching the planned 84 pts.
High Surface Area Nanoporous Polymers for Reversible Hydrogen Storage (2006)

Hydrogen adsorption using a series of nanoporous synthetic polymers has been studied. Promising results were obtained during the screening of commercially available porous polymer beads; of the polymers considered, hypercrosslinked Hypersol-Macronet MN200 resin exhibited the highest adsorption capacity for hydrogen. This initial success triggered the development of our own high surface area hypercrosslinked materials. Subjecting gel-type and macroporous vinylbenzyl chloride-based precursors swollen in dichloroethane to a Friedel−Crafts reaction catalyzed by iron trichloride afforded beads with surface areas of 1 930 and 1 300 m2/g, respectively, as calculated using the BET equation. The former polymer reversibly stores up to 1.5 wt % H2 at a pressure of 0.12 MPa and a temperature of 77.3 K. The initial heat of adsorption of hydrogen molecules onto this polymer is 6.6 kJ/mol.
The Roles of Vitreal Macrophages and Circulating Leukocytes in Retinal Neovascularization (2010)

Vitreal macrophages are attracted to the site of pathologic angiogenesis triggered by retinal ischemia, where they actively participate in vascular development.
Abstract 3729: An individualized approach to bladder cancer treatment using patient-derived cell lines to predict response to chemotherapeutic agents (2014)

Abstract Introduction: Chemotherapy (both intravesical and systemic) can reduce the risk of recurrence and progression in various stages of bladder cancer. However, recurrence after treatment failure is associated with an increased risk of progression. There are currently no established methods for predicting patient-specific responses to treatment prior to drug selection. In our studies, we have developed a novel protocol for efficient establishment of cell lines from primary human bladder tumors, which enables in vitro drug sensitivity assays using chemotherapeutic agents. Methods: Using an Institutional Review Board-approved tissue acquisition protocol, informed consent was obtained prior to specimen acquisition for all samples. Specimens were obtained during standard transurethral resection of papillary bladder tumors. Following generation of a single-cell suspension, epithelial cells were isolated using immunomagnetic cell separation and used for establishment of adherent cell cultures using a novel protocol. We performed immunohistochemistry on parental tissue as well as cultured cells to confirm that the urothelial cancer phenotype was maintained during serial passaging. For sensitivity assays, cultured cells were passaged and treated with chemotherapeutic agents, followed by assessment of cell viability using MTT assays. Results: To date, seven specimens from patients with papillary urothelial carcinoma have been obtained, resulting in the establishment of six independent adherent cell lines. All established lines have been serially passaged (as high as P10) without significant decline in growth rate, and maintained expression of CK7, uroplakin III, p53, and Ki67 in patterns similar to parental tissue. Cells from line #7 were treated with mitomycin C, docetaxel, gemcitabine, and rapamycin at three different equivalent concentrations, resulting in a unique sensitivity profile that was reproduced in a replicate experiment performed at a subsequent passage. Conclusions: We have established a novel protocol for culture and rapid expansion of primary cells from human bladder tumors for assays of drug response. Ultimately, we envision that this approach will provide a basis for the design of patient-specific therapeutic regimens for bladder cancer. Citation Format: LaMont Barlow, Chee Wai Chua, Ming Lei, G. Joel DeCastro, Ketan Badani, Mitchell Benson, James McKiernan, Michael Shen. An individualized approach to bladder cancer treatment using patient-derived cell lines to predict response to chemotherapeutic agents. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3729. doi:10.1158/1538-7445.AM2014-3729
QoS routing and link scheduling in wireless mesh backbone (2008)

Wireless Mesh Networking is envisioned as an economically viable paradigm and a promising technology for a wireless backbone. It should provide quality-of-service (QoS) guarantees the same as or similar to those offered by the legacy wireline backbones. A key factor in designing protocols for WMNs is to exploit its distinct characteristics such as immobility of mesh routers and less-constrained power consumption. In this paper, we propose a QoS-aware routing framework for WMNs. The framework addresses both scheduling and QoS-routing problems with cross-layer design. The framework allocates the transmit power of the WMN routers in a way that maximizes the spatial reuse of the network bandwidth. Using computer simulations, we show that, our optimal power allocation ensures the QoS satisfaction for the different traffic flows and achieves more efficient bandwidth utilization than the shortest-hop power allocation.
Reactive arthritis responding to antiretroviral therapy in an HIV-1-infected individual (2012)

Reactive arthritis (ReA) is an autoimmune seronegative spondyloarthropathy that occurs in response to a urogenital or enteric infection. Several studies have reported a link between ReA and HIV infection. We report a case of an HIV-1-infected patient diagnosed with a disabling ReA who failed to respond to conventional therapy but whose symptoms resolved rapidly after starting antiretroviral therapy (ART). Clinicians may not be cognizant to this phenomenon and so this case report serves to remind clinicians that initiation of antiretroviral therapy should be considered in HIV-infected patients with ReA who are refractory to standard therapy.
Improving the spatial dimensionality of Gauss-Legendre and equiangular sampling schemes on the sphere (2017)

For the fast and exact computation of spherical harmonic transform (SHT) of a band-limited signal defined on the sphere from its samples, the Gauss-Legendre (GL) and equiangular sampling schemes on the sphere require asymptotically least number of samples. In comparison to the equiangular scheme, the GL scheme has larger spatial dimensionality, defined as the number of the samples required for the exact computation of SHT. In this work, we propose an efficient GL sampling scheme with spatial dimensionality equal to that of equiangular scheme. We also propose optimisation of samples along longitude to further reduce the spatial dimensionality of equiangular, GL and efficient GL sampling schemes. Furthermore, we demonstrate that the accuracy of the SHT is not affected with the proposed reduction in the spatial dimensionality.
Mutational analysis of MYC in common epithelial cancers and acute leukemias (2006)

In addition to chromosomal translocation, the MYC gene in the N-terminal coding region showed clustered point mutations in Burkitt's lymphomas. A recent study showed that these point mutations inactivated the apoptosis activity of MYC and contributed to the tumor transformation. To see whether the point mutations of MYC are involved in tumors besides Burkitt's lymphomas, we analyzed the N-terminal cluster region of the mutations in 507 cancers from gastric, colorectal, breast and lung carcinomas, and acute leukemias, by polymerase chain reaction-based single-strand conformation polymorphism assay. However, there was no somatic mutation of the MYC gene in the cancers. The data suggest that the point mutation of the MYC gene in the N-terminal domain may be very rare and may not contribute to the development of common human cancers besides Burkitt's lymphomas.
Impact of the absorber thickness variation on the imaging performance of ArF immersion lithography (2005)

As the feature sizes on the wafer continue to shrink, the dimensions on the mask also scale down, which makes the mask topography more important. The impact of the absorber thickness of a Binary Intensity Mask (BIM) and an Alternating Aperture Phase-Shifting Mask (AAPSM) on the imaging performance of ArF lithography is investigated by using a rigorous electro-magnetic field simulator, an NA0.85 immersion scanner, and an NA0.93 conventional scanner. The simulation at NA0.85 dipole illumination for BIM shows that the mask-error enhancement factor (MEEF) for 130-nm-pitch lines and spaces increases to 3.1 from 2.5 by reducing the absorber thickness from 104 nm to 56 nm. Lower aerial-image contrast at the thinner absorber, which causes the larger MEEF, is attributed to the lower interference efficiency due to increase of transverse-magnetic component and decrease of the intensity balance between 0th- and 1st-order diffracted light. In AAPSM, the image-placement errors caused by intensity imbalance between 0 and &pi; phase-shifting spaces are influenced by the absorber thickness. It was demonstrated by the increase of dose sensitivity from 5.2 to 6.5 nm/(mJ/cm<sup>2</sup>) and line edge roughness increase from 7.1 to 8.2 nm of 150-nm-pitch lines and spaces made by using immersion process that thinning the BIM absorber from 103 to 59 nm degraded the aerial image of NA0.85 annular illumination. The conventional dry exposures by using NA0.93 dipole lithography supported the image degradation due to thinning the BIM absorber by showing that the line edge roughness of 125-nm-pitch lines and spaces increased by 1.2 nm using un-polarized illumination. The aerial-image contrast of the thicker absorber keeps better up to NA1.40, which suggests that we need to balance the merits and demerits of using the thinner absorber by giving attention to the mask topography effects.
3D warp interlocks p-aramid fabrics for composite reinforcement and ballistic vest applications: Effect of yarn density on its formability characteristics (2019)

Abstract The material forming capability becomes one of the most important characteristic of textile performance in the manufacturing of three-dimensional (3D) components to fit a 3D surface in various technical applications. In this study, different forming characteristics of 3D warp interlock fabrics in dry fabric condition were investigated. 3D warp interlock architecture with different areal density from same para-aramid yarn with a linear density of 168dtex were systematically designed and produced on automatic dobby loom with standard atmospheric conditions. The approach utilizes a low speed forming process with a predefined hemispherical shape of punch for the analysis of different forming behaviour of the fabrics specimen. The same blank-holder pressure was chosen for all the samples for better comparisons. Among several forming properties, some important characteristics have been observed, measured and analysed for a better understanding of the material forming behaviour of the different samples specimen. The research results with independent warp and weft yarn densities show a significant impact on the forming behaviours 3D warp interlock fabric. Moreover, the result of the investigation also will give a better understanding on different forming behaviours of 3D warp interlock fabric with various densities while applying in different textile application including women soft body armour.
Timing circuits for RSFQ digital systems (1995)

A low-skew frequency divider and clock controller have been designed for high-frequency timing of superconductor rapid single-flux-quantum (RSFQ) digital systems. The circuits have only about 10-ps skew between input and output signals and are applicable for multirate digital systems (e,g., oversampling analog-to-digital converter and bit-serial digital systems). Several circuits have been fabricated in conventional Nb-trilayer technology with a critical current density of 1 kA/cm/sup 2/. The most complex clock controller generates trains of 2/sup 24/ single-flux-quantum pulses with a period of less than 70 ps. The long-term relative stability of these intervals has been measured to be better than 6/spl times/10/sup -5/. The basic component of the controller, a frequency divider, operates at input frequencies above 85 GHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>