gebhart/patrepeval huggingface dataset:
DSP control of high power UPS systems feeding nonlinear loads (2005)

Many facilities, such as patient health care centers, data processing systems, and critical telecommunication links, rely on uninterruptible power supplies (UPS) to maintain a continuous supply of power in case of a line outage. In addition to requiring continuous power, many critical nonlinear loads are sensitive to incoming line transients and input harmonic voltage distortion. Conventional UPS systems operate to protect against such disturbances using complex filtering schemes employing large passive components. This paper presents the advantages of using real time digital signal processing (DSP) control of UPS systems. A DSP controlled UPS inverter and harmonic conditioning system is described and the performance is verified on a 150 kVA system.
Highly Regioselective Synthesis of Bis‐Aziridino[60]fullerene with Sulfilimine (2010)

In the course of our study of the development of a synthetic methodology for the aziridination of fullerenes, we recently reported the photochemical [2+1] cycloaddition reaction of nitrene onto C(60) generated from sulfilimine. Sulfilimines with an electron-donating group on the N atom are well known to undergo Michael-type reactions, followed by concomitant elimination of sulfide to afford the corresponding aziridines. In these reactions, sulfilimines act as a nucleophile to the electrophilic olefins. Furthermore, C(60) has characteristic features of a low LUMO level and electron-accepting properties. Therefore, it can be an electrophilic olefin. In this context, sulfilimines might react with C(60) to afford the corresponding aziridinofullerenes. We have studied the thermal reaction of (S,S)-diphenylsulfilimines with C(60) and regioselectively synthesized bis- and tris-aziridinated fullerenes. These structures were determined through spectroscopic analyses. Among these, the structure of bis-aziridinated[60]fullerene, C(60)(NCH(3))(2), was determined using single-crystal X-ray analysis. Results show that the multi-aziridination occurs exclusively at the same six-membered ring of C(60) to afford one isomer of the bis-adduct and tris-adduct.
[Os(η2‐PHS)(CO)2(PPh3)2], a Stable η2‐Thioxophosphane(HPS)‐Metal Complex (1988)

The title compound 1 is formed by cleavage of acetic acid from 1. Compound 2 is unusual in that it reacts reversibly with alcohol + acid to give 3. Good yields in the reaction 1 → 2 were only obtained if the CH3CO2 group is first transformed into the CF3CO2 group. The selenium analogue of 2 was also synthesized (R = Me, Et; L = PPh3).
Low Percentage of Signal Regulatory Protein α/β+ Memory B Cells in Blood Predicts Development of Anti-drug Antibodies (ADA) in Adalimumab-Treated Rheumatoid Arthritis Patients (2018)

An important goal for personalized treatment is predicting response to a particular therapeutic. A drawback of biological treatment is immunogenicity and the development of antibodies directed against the drug [anti-drug antibodies (ADA)], which are associated with a poorer clinical outcome. Here we set out to identify a predictive biomarker that discriminates rheumatoid arthritis (RA) patients who are more likely to develop ADA in response to adalimumab, a human monoclonal antibody against tumor necrosis factor (TNF)α. By taking advantage of an immune-phenotyping platform, LEGENDScreen™, we measured the expression of 332 cell surface markers on B and T cells in a cross-sectional adalimumab-treated RA patient cohort with a defined ADA response. The analysis revealed seven differentially expressed markers (DEMs) between the ADA<sup>+</sup> and ADA<sup>-</sup> patients. Validation of the DEMs in an independent prospective European cohort of adalimumab treated RA patients, revealed a significant and consistent reduced frequency of signal regulatory protein (SIRP)α/β-expressing memory B cells in ADA<sup>+</sup> vs. ADA<sup>-</sup> RA patients. We also assessed the predictive value of SIRPα/β expression in a longitudinal RA cohort prior to the initiation of adalimumab treatment. We show that a frequency of < 9.4% of SIRPα/β-expressing memory B cells predicts patients that will develop ADA, and consequentially fail to respond to treatment, with a receiver operating characteristic (ROC) area under the curve (AUC) score of 0.92. Thus, measuring the frequency of SIRPα/β-expressing memory B cells in patients prior to adalimumab treatment may be clinically useful to identify a subgroup of active RA subjects who are going to develop an ADA response and not gain substantial clinical benefit from this treatment.
Differential activation of RhoA and c-SRC in experimental and human fibrosis (2015)

RhoA orchestrates cytoskeleton formation, migration and mobility via c-SRC and mDia1 in different cells. RhoA/ROCK also plays a crucial role in hepatic stellate cells and hepatic fibrogenesis. Matrix stiffness promotes HSC activation via cytoskeleton modulation. The role of SRC and mDia1 in HSC, and the role of matrix stiffness, were investigated in this study.
The Fragmentation–Recombination Mechanism of the Enzyme Glutamate Mutase Studied by QM/MM Simulations (2011)

The radical mechanism of the conversion of glutamate to methylaspartate catalyzed by glutamate mutase is studied with quantum mechanical/molecular mechanical (QM/MM) simulations based on density functional theory (DFT/MM). The hydrogen transfer between the substrate and the cofactor is found to be rate limiting with a barrier of 101.1 kJ mol(-1). A careful comparison to the uncatalyzed reaction in water is performed. The protein influences the reaction predominantly electrostatically and to a lesser degree sterically. Our calculations shed light on the atomistic details of the reaction mechanism. The well-known arginine claw and Glu 171 ( Clostridium cochlearium notation) are found to have the strongest influence on the reaction. However, a catalytic role of Glu 214, Lys 322, Gln 147, Glu 330, Lys 326, and Met 294 is found as well. The arginine claw keeps the intermediates in place and is probably responsible for the enantioselectivity. Glu 171 temporarily accepts a proton from the glutamyl radical intermediate and donates it back at the end of the reaction. We relate our results to experimental data when available. Our simulations lead to further understanding of how glutamate mutase catalyzes the carbon skeleton rearrangement of glutamate.
Robotic Deployment for Environmental Sampling Applications (2005)

The use of robotics in environmental monitoring applications requires distributed sensor systems optimized for effective estimation of relevant models subject to energy and environmental constraints. The sensor carrying robots are in fact agents that facilitate the repositioning of network nodes in order to increase their coverage and accuracy. Wireless or acoustic network communication is an essential technology in transmitting the sensed as well as telemetry information between robots. Each mobile sensing node (robot) is characterized by sensing or measurement noise, localization uncertainty, and navigates in a region with a parameterized field model. This paper addresses a problem of great importance to the SN robotic deployment: adaptive sampling by selection and repositioning of mobile sensing nodes in order to optimally estimate the parameters of distributed variable field models. We present simulation results using deployment scenarios that will be experimentally validated at a future date.
Desenvolvimento de metodologia para detecção e quantificação de compostos fenólicos em vinhos. (2015)

Com este trabalho, objetivou-se desenvolver um método cromatográfico para a quantificação de compostos fenólicos em vinhos brancos e tintos por cromatografia líquida de alta eficiência. Para a validação em amostras, foram selecionados dez vinhos. Foram utilizados 25 padrões de compostos fenólicos. A separação dos compostos foi realizada utilizando-se simultaneamente os detectores de arranjos de fotodiodos e fluorescência. As fases móveis utilizadas foram: solução de dihidrogenofosfato fosfato de potássio em água ultrapura com pH ajustado para 2,05; metanol e acetonitrila e como fase estacionária foi utilizada coluna C18 (150x4,60 mm, 3&amp;#956;m). A seletividade foi confirmada através dos tempos de retenção e dos espectros de absorção dos padrões analíticos, das amostras puras e fortificadas com a mistura dos padrões. Termos para indexação: vinho, validação, cromatografia, compostos fenólicos. A linearidade das curvas analíticas para cada composto foi confirmada através do R2 das curvas, que variaram entre 0,997 e 0,999, com os limites de detecção e quantificação variando de 0,02 mg L-1 a 0,30 mg L-1 e 0,05 mg L-1 a 1,00 mg L-1. A repetibilidade variou de 1,05 a 3,39 (CV%), enquanto a precisão intermediária ficou entre 1,27 e 3,19 (CV%). A exatidão apresentou variação de 90,86% a 99,64% e de 92,20% a 99,89% nos vinhos tinto e branco, respectivamente.
Ligand-Binding Affinity Estimates Supported by Quantum-Mechanical Methods (2016)

One of the largest challenges of computational chemistry is calculation of accurate free energies for the binding of a small molecule to a biological macromolecule, which has immense implications in drug development. It is well-known that standard molecular-mechanics force fields used in most such calculations have a limited accuracy. Therefore, there has been a great interest in improving the estimates using quantum-mechanical (QM) methods. We review here approaches involving explicit QM energies to calculate binding affinities, with an emphasis on the methods, rather than on specific applications. Many different QM methods have been employed, ranging from semiempirical QM calculations, via density-functional theory, to strict coupled-cluster calculations. Dispersion and other empirical corrections are mandatory for the approximate methods, as well as large basis sets for the stricter methods. QM has been used for the ligand, for a few crucial groups around the ligand, for all the closest atoms (200-1000 atoms), or for the full receptor-ligand complex, but it is likely that with a proper embedding it might be enough to include all groups within ∼6 Å of the ligand. Approaches involving minimized structures, simulations of the end states of the binding reaction, or full free-energy simulations have been tested.
Anticipating the Future of HCI by Understanding Its Past and Present (2019)

This course is for students, practitioners, and academics who are interested in planning their careers. The rapid pace of change leaves some tools and technologies behind. We must focus our attention primarily on current developments. Why look in the rear-view mirror? Some topics that are being actively explored now will soon be of less interest, so career planning benefits from thoughtfully identifying trajectories. To make use of relevant information in other fields you must understand how their terminologies, priorities, and methods evolved. We will cover the history of several HCI fields and discuss opportunities and challenges that lie ahead. Software evolved from passively reacting to human input to today's dynamic partnership. In some areas HCI advanced steadily, elsewhere it reached dead ends or seemed to go in circles. Understanding these patterns will prepare you to respond to unexpected developments in years to come. The forces that shaped HCI in computer science, human factors, information systems, information science, and design are covered, with examples and implications for our new era.
Development of Taxon-Specific Sequences of Common Wheat for the Detection of Genetically Modified Wheat (2005)

Qualitative and quantitative Polymerase Chain Reaction (PCR) systems aimed at the specific detection and quantification of common wheat DNA are described. Many countries have issued regulations to label foods that include genetically modified organisms (GMOs). PCR technology is widely recognized as a reliable and useful technique for the qualitative and quantitative detection of GMOs. Detection methods are needed to amplify a target GM gene, and the amplified results should be compared with those of the corresponding taxon-specific reference gene to obtain reliable results. This paper describes the development of a specific DNA sequence in the waxy-D1 gene for common wheat (Triticum aestivum L.) and the design of a specific primer pair and TaqMan probe on the waxy-D1 gene for PCR analysis. The primers amplified a product (Wx012) of 102 bp. It is indicated that the Wx012 DNA sequence is specific to common wheat, showing homogeneity in qualitative PCR results and very similar quantification accuracy along 19 distantly related common wheat varieties. In Southern blot and real-time PCR analyses, this sequence showed either a single or a low number of copy genes. In addition, by qualitative and quantitative PCR using wx012 primers and a wx012-T probe, the limits of detection of the common wheat genome were found to be about 15 copies, and the reproducibility was reliable. In consequence, the PCR system using wx012 primers and wx012-T probe is considered to be suitable for use as a common wheat-specific taxon-specific reference gene in DNA analyses, including GMO tests.
Quantitative Measures of Reliability and Sensitivity of Nanoparticle-Based Sensors in Detecting Volatile Organic Compounds (2019)

We herein provide quantitative measures of sensors' reliability and sensitivity as a function of the sensor's capacity (maximum detection signal or saturation state) in addition to other adsorption-desorption parameters that define the detection signals toward volatile organic compounds (VOCs). The measures we have developed show differentiation between irregular dispersed points of sensors with low and high capacities. We show that the sharpest capacity that separates between the two types of distribution points, viz the reliability limit (RL), is tightly linked with the desorption constant <i>k</i> <sub>d</sub>. Less sharp RLs give interpretations of other reliability indicators. RL also provides information about the reliability of detecting signals of VOCs for a given sensor and sensors for a particular VOC. We show that sensors with high capacities are more reliable and sensitive to detecting signals of VOCs than sensors with lower capacities.
Effect of Cimetidine Administration on the Pharmacokinetics of Pirmenol (1992)

The potential for a drug-drug interaction between pirmenol, an extensively metabolized antiarrhythmic agent, and cimetidine, an inhibitor of hepatic drug-metabolizing enzymes, was evaluated in eight healthy adults. A single 150-mg oral dose of pirmenol was administered on study days 1 and 8 and oral cimetidine, 300-mg QID, was administered on study days 4 through 11. Plasma and urine samples were collected after each pirmenol dose for determination of pirmenol concentration. Mean pirmenol concentration-time curves and pharmacokinetic parameters, including elimination rate constant, were not significantly altered by concomitant administration of cimetidine.
Thermodynamic Viability of Hydrogen Atom Transfer from Water Coordinated to the Oxygen-Evolving Complex of Photosystem II (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThermodynamic Viability of Hydrogen Atom Transfer from Water Coordinated to the Oxygen-Evolving Complex of Photosystem IIM. Tyler Caudle and Vincent L. PecoraroView Author Information Department of Chemistry, University of Michigan 930 N. University Blvd., Ann Arbor, Michigan 48109-1055 Cite this: J. Am. Chem. Soc. 1997, 119, 14, 3415–3416Publication Date (Web):April 9, 1997Publication History Received2 December 1996Published online9 April 1997Published inissue 1 April 1997https://pubs.acs.org/doi/10.1021/ja9641158https://doi.org/10.1021/ja9641158rapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views507Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Bond cleavage,Cluster chemistry,Oxidation,Oxidation state,Transition metals Get e-Alerts
Effect of wither application of an analogue of pig appeasing pheromone on encounters between unfamiliar mini-pigs (2022)

The new method of applying PAP improved welfare of mini-pigs (as models of domestic pigs) by reducing fighting, among other interesting results. PAP seems thus a promising biomimetic tool to enhance animal welfare in pig production systems.
Kontraktions-vermittelnde Signalwege in Lebern zirrhotischer CCl4-Ratten mit erhöhtem intrahepatischem Gefäßwiderstand: Hochregulation der RhoA- und Rho-Kinase Expression und Rho-Kinase Überaktivität (2008)

Hintergrund: Bei der Leberzirrhose trägt ein erhöhter intrahepatischer Widerstand für den portalvenösen Ausfluss erheblich zur portalen Hypertension bei. Bei Ratten mit sekundär biliärer Leberzirrhose durch Gallengangsligatur (BDL) ist an der Widerstands-Erhöhung eine erhöhte Aktivität der Kontraktions-vermittelnden Rho-Kinase im intrahepatischen Gefäßbett beteiligt (Gut2006;55), die sich durch eine Hochregulation der RhoA- und Rho-Kinase Expression erklärt. Rho-Kinase wird durch die GTPase RhoA aktiviert, welche wiederum durch Vasokonstriktor-Rezeptoren gesteuert wird. Auch in zirrhotischen Lebern von Patienten mit Leberzirrhose kommt es zu einer erhöhten Rho-Kinase Aktivität (Gut2006;55). Hier haben wir die Expression von RhoA und der Rho-Kinase sowie die Aktivität der Rho-Kinase in Lebern von Ratten mit CCl4-induzierter mikronodulärer Leberzirrhose untersucht. Methoden: Die Leberzirrhose der Ratten wurde durch CCl4 induziert (inhalativ, 2–3 Monate). RhoA- und Rho-Kinase mRNA wurde über quantitative RT-PCR (Taqman) bestimmt. Protein-Expressionen bzw. –Phosphorylierungen in Leberhomogenaten wurden über Western-Blot Analyse mit phosphospezifischen bzw. nicht-phosphospezifischen Antikörpern untersucht. Zur Untersuchung der Rho-Kinase Aktivität wurde die Phosphorylierung des Rho-Kinase Substrates Moesin (Thr558) verglichen. Ergebnisse: Die mRNA-level von RhoA und der Rho-Kinase waren in Lebern von CCl4-Ratten im Vergleich zu nicht-zirrhotischen Kontrollen erhöht. Auch die Protein-Expressionen von RhoA und der Rho-Kinase war in Lebern der CCl4-Ratten hochreguliert. Dies ging einher mit einer erhöhten Rho-Kinase Aktivität in Lebern der CCl4-Ratten, verglichen zu nicht-zirrhotischen Kontrollen. Diskussion: Auch bei Ratten mit CCl4-induzierter mikronodulärer Leberzirrhose könnte eine Hochregulation des RhoA/Rho-Kinase Signalweges im intrahepatischen Gefäßbett die Entstehung der portalen Hypertension begünstigen.
Monolithically Integrated Gain-Flattened Ring Mode-Locked Laser for Comb-Line Generation (2011)

We demonstrate broadband comb-line generation from an integrated multiple quantum well InGaAsP/InP passively mode-locked laser (MLL) with a gain flattening filter (GFF) based on an asymmetric Mach-Zehnder interferometer. The intracavity filter flattens the nonuniform gain profile of the semiconductor material providing a more uniform net cavity gain. The GFF MLL has a -10 dB comb span of 15 nm (1.88 THz), the widest spectral width yet demonstrated for an integrated QW MLL at 1.55 μm . The measured optical linewidth at the center of the comb is 29 MHz, the -20 dB RF linewidth 500 KHz, while the output spectrum is phase-locked to produce 900 fs pulses at a repetition rate of 30 GHz with 4.6 ps integrated jitter from 100 Hz to 30 MHz.
Applications of Quasi-Markov Simplex Models Across Populations (1981)

A linear structural model for comparing quasi-Markov models across populations is demonstrated. A confirmatory factor analysis formulation of the simplex model is also developed for between group comparisons. A variety of possible applications of this approach are suggested.
Demonstration of 20-Gb/s All-Optical XOR Gate by Four-Wave Mixing in Semiconductor Optical Amplifier With RZ-DPSK Modulated Inputs (2004)

We propose and demonstrate an all-optical XOR gate at 20 Gb/s using four-wave mixing in a semiconductor optical amplifier (SOA), with return-to-zero differential phase-shifted keying modulated input signals. With such constant intensity modulation format, the patterning-induced degradation in SOA is also alleviated. The proposed scheme is robust and feasible for optical logic operation at ultrahigh speeds.
The role of Solobacterium moorei in oral malodour (2013)

This study aims to analyze the correlation between Solobacterium moorei (S. moorei), both on the tongue and in saliva, and several oral malodour- and clinical parameters. Data from 193 patients visiting a halitosis clinic were used for analysis. A questionnaire assessed their general health, allergies, medication, smoking habits and oral hygiene. Following halitosis parameters were recorded: organoleptic score (OLS) (0-5), total concentration of volatile sulfur compounds (VSC) (Halimeter), individual concentrations of VSC (Oral Chroma), tongue coating (MTCI, WTCI and mWTCI), salivary parameters (flow rate and pH), oral hygiene, tonsil health and periodontal health. In all subjects, microbiological samples were collected from the tongue coating and from the saliva, and a quantitative polymerase chain reaction was performed to detect S. moorei. A significant correlation could be established between S. moorei, from both tongue and saliva, and several breath parameters (OLS, H2S, CH3SH, (CH3)2S and total VSCs), tongue coating indices and periodontal indices (gingivitis, periodontitis and oral hygiene). This study suggests a strong association between the presence of S. moorei and oral malodour (s54747).