gebhart/patrepeval huggingface dataset:
A Comprehensive Review of Pacritinib in Myelofibrosis (2015)

The first-in-class JAK1/JAK2 inhibitor ruxolitinib inhibits JAK/STAT signaling, inducing durable reductions in splenomegaly and constitutional symptoms in patients with myelofibrosis. However, the association of ruxolitinib therapy with myelosuppression indicates the continued need for optimal treatment choices in myelofibrosis. Pacritinib, a dual JAK2 and FLT3 inhibitor, improves disease-related symptoms and signs with manageable gastrointestinal toxicity in patients with myelofibrosis with splenomegaly and high-risk features, without causing overt myelosuppression, and therefore may provide an important treatment option for a range of patients with myelofibrosis. This article examines the role of JAK2 and FLT3 signaling in myelofibrosis and provides an overview of the clinical development of pacritinib as a new therapy for myelofibrosis.
Fabrication, Structure Characterization, and Performance Testing of Piezoelectret-Film Sensors for Recording Body Motion (2017)

During muscle contractions, radial-force distributions are generated on muscle surfaces due to muscle-volume changes, from which the corresponding body motions can be recorded by means of so-called force myography (FMG). Piezo-or ferroelectrets are flexible piezoelectric materials with attractive materials and sensing properties. In addition to several other applications, they are suitable for detecting force variations by means of wearable devices. In this paper, we prepared piezoelectrets from cellular polypropylene films by optimizing the fabrication procedures, and developed an FMG-recording system based on piezoelectret sensors. Different hand and wrist movements were successfully detected on able-bodied subjects with the FMG system. The FMG patterns were evaluated and identified by means of linear discriminant analysis and artificial neural network algorithms, and average motion-classification accuracies of 96.1% and 94.8%, respectively, were obtained. This paper demonstrates the feasibility of using piezoelectret-film sensors for FMG and may thus lead to alternative methods for detecting body motion and to related applications, e.g., in biomedical engineering or structural-health monitoring.
Poquëpar (2008)

Piper politaereum Piper politaereum Varias plantas reciben el mismo nombre. En el marco de este estudio se colectó solamente una. Significado del nombre Poquë: hinchazón. USO YANESHA Hinchazón de las piernas Estas plantas sirven en caso de los edemas que se producen en las piernas durante el embarazo. Para ello se hacen hervir las hojas en agua y se aplican en forma de cataplasma; posteriormente se prepara un baño con las hojas y se frotan las piernas suavemente. También se puede hacer una v...
Shape Memory Characteristics of Thermoelastic TiNi System Rapid-Solidified Fibers (2002)

Ti50Ni50-xCux (x=0,5,10,15at%) fine fibers (diameter= φ 80 μ m, length=20cm&acd;1m) were successfully developed by the arc-melted rapid-solidification method. It has been very difficult to do the conventional melt-work processing from the bulk material of this alloy to very fine fiber because of the brittleness from metallic compounds especially in the range of Cu≧8at%. The fibers showed good shape memory effect. As Cu content increased, the temperature hysteresis (=Af-Mf) of recovery strain-temperature curves as well as DSC curves became smaller and the tensile strength showed more than 1000MPa in Ti50Ni40Cu10at%. Therefore, the developed rapid-solidified, thermoelastic fine fiber actuator/sensor materials have high potentiality of applications for micro-machines and the fillers of smart composites.
Description and User Instructions for the Quaternion_to_Orbit_v3 Software (2012)

For a given inertial frame of reference, the software combines the spacecraft orbits with the spacecraft attitude quaternions, and rotates the body-fixed reference frame of a particular spacecraft to the inertial reference frame. The conversion assumes that the two spacecraft are aligned with respect to the mutual line of sight, with a parameterized time tag. The software is implemented in Python and is completely open source. It is very versatile, and may be applied under various circumstances and for other related purposes. Based on the solid linear algebra analysis, it has an extra option for compensating the linear pitch. This software has been designed for simulation of the calibration maneuvers performed by the two spacecraft comprising the GRAIL mission to the Moon, but has potential use for other applications. In simulations of formation flights, one needs to coordinate the spacecraft orbits represented in an appropriate inertial reference frame and the spacecraft attitudes. The latter are usually given as the time series of quaternions rotating the body-fixed reference frame of a particular spacecraft to the inertial reference frame. It is often desirable to simulate the same maneuver for different segments of the orbit. It is also useful to study various maneuvers that could be performed at the same orbit segment. These two lines of study are more timeand labor-efficient if the attitude and orbit data are generated independently, so that the part of the data that has not been changed can be recycled in the course of multiple simulations.
Incremental observable-area modeling for cooperative tracking (2002)

We propose an observable-area model of the scene for real-time cooperative object tracking by multiple cameras. The knowledge of partners' abilities is necessary for cooperative action whatever task is defined. In particular, for the tracking a moving object in the scene, every active vision agent (AVA), a rational model of the network-connected computer with an active camera, should therefore know the area in the scene that is observable by each AVA. Each AVA should then decide its target object and gazing direction taking into account other AVAs' actions. To realize such a cooperative gazing, the system gathers all the observable-area information to incrementally generate the observable-area model at each frame during the tracking. Hence, the system cooperatively tracks the object by utilizing both the observable-area model and the object's motion estimated at each frame. Experimental results demonstrate the effectiveness of the cooperation among the AVAs with the help of the proposed observable-area model.
Developing single-source documentation for multiple formats (1996)

Our main goal is to develop online and hardcopy reference documentation from a single source. To accomplish this goal we had to make decisions about the tools we are going to use, what information we are going to include, how we will design and present the modular information, linking and indexing strategies, and testing. This paper describes the experiences of SAS Institute in developing single-source documentation for presentation in multiple formats.
An Improved Technique for Sequential R-, Q- and C-Banding of Bone Marrow Chromosomes (1983)

A procedure for the sequential staining of metaphase cells to provide R-banding, Q-banding and C-banding of chromosomes is described. The combined techniques allow more precise identification of marker chromosomes and more accurate definition of breakpoints in the consistent chromosome translocations that are associated with certain human malignancies.
ChemInform Abstract: Reaction of Enol Ethers with Lead Tetraacetate: An Improved Method for the Synthesis of α‐Methoxy Ketones. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Characterization of a novel biosurfactant produced by marine hydrocarbon-degrading bacterium Achromobacter sp. HZ01 (2016)

One novel lipopeptide was purified and characterized. The novel biosurfactant exhibited good potential applications, such as bioremediation.
Security concerns for mobile information systems in health care (2002)

We study the mutually restricting problems of permanent availability and legally demanded security of patient data in clinical information systems. Inefficiencies in today's clinical information management call for an integrated technological support for hospitals. In particular, client/server solutions offer the flexibility and spatial independence appreciated in health care. On the other hand, mobile client applications having access from nearly everywhere in a hospital to servers containing sensitive data arouse severe security problems. Additionally, the need for 24 hours per day and 7 days per week availability of patient data in hospital run information systems defines a conflicting border condition. We present a proposed approach developed in the Swiss National Science Foundation project MobiMed to support clinical processes technologically, including access control which is compatible with security mechanisms as well as everyday practical work consideration in clinical environments.
IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions (2002)

Atopic dermatitis (AD) is a pruritic inflammatory skin disease. Because IL-18 directly stimulates T cells and mast cells to release AD-associated molecules, Th2 cytokines, and histamine, we investigated the capacity of IL-18 to induce AD-like inflammatory skin disease by analyzing KIL-18Tg and KCASP1Tg, which skin-specifically overexpress IL-18 and caspase-1, respectively. They spontaneously developed relapsing dermatitis with mastocytosis and Th2 cytokine accumulation accompanied by systemic elevation of IgE and histamine. Stat6-deficient KCASP1Tg displayed undetectable levels of IgE but manifested the same degree of cutaneous changes, whereas IL-18-deficient KCASP1Tg evaded the dermatitis, suggesting that IL-18 causes the skin changes in the absence of IgE/stat6. KIL-18Tg and IL-1-deficient KCASP1Tg took longer to display the lesion than KCASP1Tg. Thus, AD-like inflammation is initiated by overrelease of IL-18 and accelerated by IL-1. Our present study might provide insight into understanding the pathogenesis of and establishing therapeutics for chronic inflammatory skin diseases including AD.
Medical image denoising from similar patches derived by Rough Set (2013)

Current state-of-the-art research on denoising involves patch similarity. The similar patches are obtained either from image itself or from dictionary of patches. This paper proposes a new way to find similar patches from a given image using Rough Set Theory (RST). Search for similar patches is usually restricted locally. However, a global search could fetch patches which are more similar. The current RST based approach is enabling such search global and hence satisfying the Non-local principal which is the basis for patch based denoising. Like a few other denoising techniques, the framework of nonlocal means and principal component analysis both are then utilized to denoise medical images. The main essence of the current work reflects true sense of non-locality of similar patches. Exhaustive experiments clearly indicate comparability of the current proposal to the state-of-the-art methods in the light of several evaluation measures.
Design of a 33-Knot Aluminum Catamaran Ferry (2000)

This paper presents the results of an investigation on the suitability of using hull panels with alternating fixed and floating frames for a 30–40 knot aluminum catamaran ferry. A prototype 4.6 m × 1.8 m bottom hull panel with alternating frames is analyzed numerically and physically tested. The corresponding finite-element analyses and test results are in good agreement. The results show that the floating frame hull panel design is a feasible structure for an aluminum catamaran. The floating frame structure was then used for a 33-knot, 250-passenger aluminum catamaran ferry designed to meet the ABS High Speed Craft rules. A midship section of the catamaran hull was analyzed using the finite-element method. Catamaran weight estimates, heave and pitch motions, and powering estimates are also provided. The results show that the alternating floating frame structure was within the ABS rules stress allowables.
Design and performance of a Nafion dryer for continuous operation at CO 2 and CH 4 air monitoring sites (2013)

Abstract. In preparation for routine deployment in a network of greenhouse gas monitoring stations, we have designed and tested a simple method for drying ambient air to near or below 0.2% (2000 ppm) mole fraction H2O using a Nafion dryer. The inlet system was designed for use with cavity ring-down spectrometer (CRDS) analyzers such as the Picarro model G2301 that measure H2O in addition to their principal analytes, in this case CO2 and CH4. These analyzers report dry-gas mixing ratios without drying the sample by measuring H2O mixing ratio at the same frequency as the main analytes, and then correcting for the dilution and peak broadening effects of H2O on the mixing ratios of the other analytes measured in moist air. However, it is difficult to accurately validate the water vapor correction in the field. By substantially lowering the amount of H2O in the sample, uncertainties in the applied water vapor corrections can be reduced by an order of magnitude or more, thus eliminating the need to determine instrument-specific water vapor correction coefficients and to verify the stability over time. Our Nafion drying inlet system takes advantage of the extra capacity of the analyzer pump to redirect 30% of the dry gas exiting the Nafion to the outer shell side of the dryer and has no consumables. We tested the Nafion dryer against a cryotrap (−97 °C) method for removing H2O and found that in wet-air tests, the Nafion reduces the CO2 dry-gas mixing ratios of the sample gas by as much as 0.1 ± 0.01 ppm due to leakage across the membrane. The effect on CH4 was smaller and varied within ± 0.2 ppb, with an approximate uncertainty of 0.1 ppb. The Nafion-induced CO2 bias is partially offset by sending the dry reference gases through the Nafion dryer as well. The residual bias due to the impact of moisture differences between sample and reference gas on the permeation through the Nafion was approximately −0.05 ppm for CO2 and varied within ± 0.2 ppb for CH4. The uncertainty of this partial drying method is within the WMO compatibility guidelines for the Northern Hemisphere, 0.1 ppm for CO2 and 2 ppb for CH4, and is comparable to experimentally determining water vapor corrections for each instrument but less subject to concerns of possible drift in these corrections.
Telephone Call Centers: Tutorial, Review, and Research Prospects (2003)

Telephone call centers are an integral part of many businesses, and their economic role is significant and growing. They are also fascinating sociotechnical systems in which the behavior of customers and employees is closely intertwined with physical performance measures. In these environments traditional operational models are of great value—and at the same time fundamentally limited—in their ability to characterize system performance. We review the state of research on telephone call centers. We begin with a tutorial on how call centers function and proceed to survey academic research devoted to the management of their operations. We then outline important problems that have not been addressed and identify promising directions for future research.
Abstract 1609: Proline-directed kinase signaling in human hepatocellular carcinomas developed on non-fibrotic liver (2014)

Abstract Ten to 40% hepatocellular carcinoma (HCC) arise on non-cirrhotic liver, including 5% on non-fibrotic liver (nfHCC). These tumors provide an interesting model for the analysis of the hepatocarcinogenesis pathways without the confounding factors associated with cirrhosis. Carcinogenesis has been often associated with the deregulation of phosphorylation-dependent signaling pathways. Quantitative phosphoproteomics recently allowed us to unravel the specific activation of proline-directed kinases (PDK) in nfHCC. Our aim was then to use medium throughput analytical tools (Alphascreen® and AMMP®) to evaluate the activation status of PDK dependent signaling pathways in a series of nfHCC samples. We have used a phosphoproteomics set comprising surgical samples from nfHCC (METAVIR F0 or F1) and samples of histologically normal livers. Proteins were extracted and analyzed for the activation status of select signaling pathways such as MAPK using both Alphascreen® and AMMP® technologies. Because MAPK are prototypic PDKs and are deregulated in many cancers, we analyzed their activation in a series of 25 nfHCC as compared to 6 non-tumor samples and found an overall increased activity in nfHCC samples. Moreover the phosphorylation status of Calnexin, a MAPK substrate found in the phosphoproteomics analysis was monitored and compared in nfHCC samples. In conclusion, we have identified phosphopeptide signatures in human samples of nfHCC that led to the identification of a deregulated PDK-dependent network in those tumors. The elucidation of the functional causes and consequences of such deregulation is ongoing. Citation Format: Saïd Taouji, Kristen Leong, Lee A. Beausang, Daniela Arma, Violaine Moreau, Charles Balabaud, Paulette Bioulac-Sage, Jessica Zucman-Rossi, Martin Latterich, Jean Rosenbaum, Eric Chevet. Proline-directed kinase signaling in human hepatocellular carcinomas developed on non-fibrotic liver. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1609. doi:10.1158/1538-7445.AM2014-1609
High power 3-phase to 3-phase matrix converter using dual-gate GaN bidirectional switches (2018)

Highly efficient three-phase to three-phase matrix converters using Gallium nitride (GaN) bidirectional switches with both high current and high breakdown voltage are demonstrated. The GaN switch with dual gates works as a bidirectional switch by a single device, while a conventional bidirectional switch consists of four devices by two Insulated Gate Bipolar Transistors (IGBTs) and two diodes. In addition, the GaN bidirectional switch is also free from the voltage offsets for the current conduction so that the GaN-based matrix converter enables small size and highly efficient AC/AC conversion. Improvement of the device performance including the introduction of the recessed gate enables the low on-state resistance with stable operation free from current collapse. The maximum drain current reaches 100 A together with the breakdown voltage of 1340 V. The fabricated three-phase to three-phase matrix converter exhibits the maximum conversion efficiency of 98% at 1 kW output power with the expectation that the maximum output power can reach 10 kW or more by the high current device.
A Survey of Payment Card Industry Data Security Standard (2010)

Usage of payment cards such as credit cards, debit cards, and prepaid cards, continues to grow. Security breaches related to payment cards have led to billion dollar losses annually. In order to offset this trend, major payment card networks have founded the Payment Card Industry (PCI) Security Standards Council (SSC), which has designed and released the PCI Data Security Standard (DSS). This standard guides service providers and merchants to implement stronger security infrastructures that reduce the risks of security breaches. This article mainly discusses the need for the PCI DSS and the data security requirements defined in the standard to address the ongoing security issues, especially those pertaining to payment card data handling. It also surveys various technical solutions, offered by a few security vendors, for merchant companies and organizations involved in payment card transaction processing to comply with the standard. The compliance of merchants or service providers to the PCI DSS are assessed by PCI Qualified Security Assessors (QSAs). This article thus discusses the requirements to become PCI QSAs. In addition, it introduces the PCI security scanning procedures that guide the scanning of security policies of a merchant or service provider and prepare relevant reports. We believe that this survey sheds light on potential technical research problems pertinent to the PCI DSS and its compliance.
Femtosecond electron relaxation in InGaAs lattice matched to InP (1992)

Carrier energy relaxation times have been measured in In<SUB>0.53</SUB>Ga<SUB>0.47</SUB>As grown by MBE on InP. Layer thicknesses from 0.5 to 3 microns have been studied. An NaCl color center laser using additive pulse modelocking supplied 150 femtosecond pulses with photon energies between 780 and 806 meV. These were used for time resolved optical saturation measurements near the 750 meV material bandgap. Carrier densities between 0.4 X 10<SUP>18</SUP> and 5.7 X 10<SUP>18</SUP> were achieved. Lifetimes of about 150 femtoseconds are reported. These are observed to decrease with increasing carrier density and with decreasing photon energy.
Use of Baculoviruses as Biological Insecticides (2003)

Baculoviruses have been isolated from a wide range of invertebrates. Their development as pest control agents spans over 40 years, although records of their discovery and use date from considerably earlier (). The baculoviruses from Lepidoptera (butterflies and moths), Hymenoptera (sawflies only), and Coleoptera (beetles) present the best options for pest control, and thus most research on baculovirus insecticides has concentrated on these orders. Baculovirus insecticides have been used in a wide range of situations from forests and fields to food stores and greenhouses.
Correction to: The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma (2021)

An amendment to this paper has been published and can be accessed via the original article.
Microchip optical parametric oscillators (1997)

The frequency-doubled output of a high-power passively Q-switched Nd:YAG microchip laser has been used to pump a KTP doubly resonant miniature monolithic Fabry-Perot (microchip) optical parametric oscillator (OPO). The OPO operated with 20% conversion efficiency, generating 8.4 μJ of 1.064-μm radiation in 600-ps pulses, with excellent mode quality and pulse-to-pulse stability. This is the most compact OPO system yet demonstrated, generating the shortest pulses reported for an OPO pumped with Q-switched pulses. This technology makes it possible to obtain miniature optical system operating at any wavelength throughout the near IR, visible, and UV.
Circular Dichroism in Biological Photonic Crystals and Cubic Chiral Nets (2011)

Nature provides impressive examples of chiral photonic crystals, with the notable example of the cubic so-called srs network (the label for the chiral degree-three network modeled on SrSi2) or gyroid structure realized in wing scales of several butterfly species. By a circular polarization analysis of the band structure of such networks, we demonstrate strong circular dichroism effects: The butterfly srs microstructure, of cubic I4(1)32 symmetry, shows significant circular dichroism for blue to ultraviolet light, that warrants a search for biological receptors sensitive to circular polarization. A derived synthetic structure based on four like-handed silicon srs nets exhibits a large circular polarization stop band of a width exceeding 30%. These findings offer design principles for chiral photonic devices.