gebhart/patrepeval huggingface dataset:
Control of soil-transmitted helminths in sub-Saharan Africa: Diagnosis, drug efficacy concerns and challenges (2010)

Soil-transmitted helminthiasis (STH) occur throughout the developing world and remain a major public health problem in the poorest communities with enormous consequences on health and development of school-aged and preschool children. The extent of the problem has long been neglected because these diseases rarely kill at a young age, due to their insidious and chronic nature. Today there exists a momentum and an unprecedented opportunity for a cost-effective control of these neglected tropical diseases. The control of these diseases has become a priority on the agenda of many governments, donors and international agencies, which provides important funding opportunities for STH control through integration and co-implementation of control interventions. In the era of preventive chemotherapy, the intensification of mass administration of anthelminthic drugs will result in epidemiological changes of STH transmission levels, with a rapid increase of light infections as far as control programmes are successful. As consequence, the current diagnostic tools may not be always appropriate and may therefore require adaptation or development of alternative assays adapted to the stage of control. This paper reviews aspects relevant to diagnosis and appropriate tools for accurate surveillance and monitoring of STH control programmes and drug efficacy. Prospects, opportunities and challenges for the control are discussed.
Improving Transaction Server Performance under Heavy Loads with Differentiated Service and Active Network Interfaces (2005)

Transaction based Web services that demand realtime performance guarantees, such as online auctions, stock trading and real-time database servers generally require a higher level of security and performance compared to normal Web services. To improve server throughput of servers for such applications under heavy loads or under denial of service attacks, it is necessary to service requests differentially, giving preference to on-going or imminent client requests. We show how such facilities can be efficiently implemented on an active network adapter based gateway that controls accesses to a pool of backend servers. Using an experimental prototype based around a dual-ported active NIC, we show how a differentiated service policy can be implemented on such a gateway to bound the server response time and to improve server throughputs under heavy loads
WDM-PON Management and Control by Auxiliary Management and Control Channel for 5G Mobile Fronthaul (2021)

The demand for fifth generation (5G) mobile systems has been exploding. There are strict latency and transmission capacity requirements, especially in the optical fiber section called the mobile fronthaul. A wavelength division multiplexing passive optical network (WDM-PON) system is an attractive solution to accommodate the high demand of traffic. However, wavelength management, which is important in a WDM-PON system, has not been sufficiently studied at the system level. In previous studies, control by a management control channel independent of the client signal, called the auxiliary management and control channel (AMCC), has been considered in many cases. In most of these studies, physical layer evaluation, such as the effect of superimposing the management control channel, was conducted for feasibility studies, and it was only confirmed that the effect was minor by measuring the bit error rate. In this paper, we review and compare the superimposition schemes of the AMCC to clarify operating conditions such as modulation format and modulation index of the AMCC signals. In addition, we propose a WDM-PON system managed using AMCC for ONU activation, wavelength adjustment and alive monitoring. We then discuss the connection of a WDM-PON prototype system we developed to a 5G mobile system to evaluate the effect of throughput on user equipment. The results indicate that the WDM-PON prototype system did not degrade (less than 2%) the downlink throughput even when the wavelength adjustment function was used against wavelength drift.
An Efficient Classification Method for Knee MR Image Segmentation (2016)

Aiming at application to automated recognition of knee bone magnetic resonance (MR) images, an evolutional classification method called CBGA-LDIC is proposed. CBGA-LDIC finds an appropriate cell set towards efficient image segmentation. This method uses location-dependent image classification (LDIC), which is integrated by genetic algorithm (GA) combined with case based reasoning (CB). LDIC introduces a new but local heuristics for image segmentation, and defines multiple classifiers dependent on location. Each classifier is trained by Gaussian mixture model. CBGA-LDIC decomposes the whole image into some cells, makes a set of cells, and then trains classifiers. Since the knee bones and/or their formations are similar in their location, good combinations of cells seem useful for other clients and are stored in case bases. Thus this method is expected to produce the better results when good combinations of cells are selected from cases as initial individuals of GA, especially through its repetition on restarting GA. This is verified by some experimentations shown in this paper.
Additive activity of royal jelly and honey against Pseudomonas aeruginosa. (2008)

As natural products garner attention in the medical field, the emergence of antibiotic-resistant strains of bacteria has confounded the current use of antibiotic therapy, leading to the re-examination of earlier remedies such as honey and royal jelly (RJ). Four varieties of honey and one variety of freshly reaped RJ were used to evaluate the additive antimicrobial action against Pseudomonas aeruginosa (ATCC 27853). Initially, honey and RJ were used separately to determine their minimum inhibitory concentration (MIC) against the tested strain. Next, sub-MIC concentrations of honey and RJ were incorporated into media to determine the minimum additive inhibitory concentration. When tested separately, the MIC of the four varieties of honey ranged from 12-18 percent (volume/volume; v/v), and that of RJ was 4 percent (v/v). When combined with RJ, each honey variety tested showed a greater than 90-percent drop in MIC using 3-percent (v/v) RJ, a 66.6-percent drop in MIC using 2-percent (v/v) RJ, and a 50-percent MIC drop with 1-percent (v/v) RJ. The MIC of RJ dropped by 75 percent when used with the half concentration of honey that alone provides the MIC and by 50 percent when used with one-third the concentration of honey that alone provides the MIC. A strong linear correlation exists between the MIC drop of each variety of honey and RJ. With increasing interest in the use of alternative therapies and as the development of antibiotic-resistant bacteria spreads, honey and RJ may receive renewed recognition as wound healers.
ChemInform Abstract: Homochiral Matching in the Diels‐Alder Cyclodimerization of 2‐Vinyl‐7‐ oxabicyclo(2.2.1)hept‐2‐ene Derivatives. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Assessment of Atherothrombotic Risk in Patients With Type 2 Diabetes Mellitus (2023)

We developed and validated a risk score for atherothrombotic events, leveraging 16 routinely assessed clinical variables in patients with T2DM. The score has the potential to improve risk assessment and inform clinical decision-making.
A correlation map of genome-wide DNA methylation patterns between paired human brain and buccal samples (2021)

Abstract Epigenome-wide association studies (EWAS) assessing the link between DNA methylation (DNAm) and phenotypes related to structural brain measures, cognitive function, and neurodegenerative diseases are becoming increasingly more popular. Due to the inaccessibility of brain tissue in humans, several studies use peripheral tissues such as blood, buccal swabs, and saliva as surrogates. To aid the functional interpretation of EWAS findings in such settings, there is a need to assess the correlation of DNAm variability across tissues in the same individuals. In this study, we performed a correlation analysis between DNAm data of a total of n=120 matched post-mortem buccal and prefrontal cortex samples. We identified nearly 25,000 (3% of approximately 730,000) cytosine-phosphate-guanine (CpG) sites showing significant (False Discovery Rate q &lt; 0.05) correlations between buccal and PFC samples. Correlated CpG sites showed a preponderance to being located in promoter regions and showed a significant enrichment of being determined by genetic factors, i.e. methylation quantitative trait loci (mQTL), based on buccal and dorsolateral prefrontal cortex mQTL databases. Our novel buccal-brain DNAm correlation map will provide a valuable resource for future EWAS using buccal samples for studying DNAm effects on phenotypes relating to the brain. All correlation results are made freely available to the public online.
RECAP: Region-Aware Cache Partitioning (2013)

In recent years, high performance computing systems have obtained more processing cores and share a last level cache (LLC). However, as their number grows, the core-to-way ratio in the LLC increases, presenting problems to existing cache partitioning techniques which require more ways than cores. Furthermore, effective energy management of the LLC becomes increasingly important due to its size. This paper proposes a Region Aware Cache Partitioning (RECAP), an LLC energy-saving scheme for high-performance, many-core processors. RECAP partitions the data within the cache into shared and private regions. Applications only access the ways containing the data that they require, realising dynamic energy savings. Any ways that are not within the shared or private regions can be turned off to save static energy. We evaluate our scheme using an 8-core CMP running multi-programmed workloads and show that it achieves 17% dynamic and 13% static energy savings in the shared LLC with a 15% performance gain. Across our multi-threaded applications, we achieve 17% dynamic and 41% static energy savings with no impact on performance.
Effect of Lactobacillus paracasei N1115 and fructooligosaccharides in nonalcoholic fatty liver disease (2019)

N1115, FOS and synbiotics are effective in the prevention and treatment of NAFLD. Our data support the translation of these agents into clinical evaluation in human subjects with NAFLD and/or associated risk factors.
Video Identification Using Spatio-temporal Salient Points (2009)

Automatic identification of video is a key technique to various applications such as content based retrieval, copyright protection and broadcast monitoring. In this paper, we present a novel video identification scheme via spatio-temporal salient points. To achieve higher robustness to content preserved manipulations, especially geometric distortions, salient points are detected from both spatial and temporal aspects. The salient points are found to be invariant in a series of distortions. In addition, we have compared our approach with a state-of-the-art one on diverse sequences and superior performances on detection accuracy have been observed in the proposed work.
Usability assessment of Versius, a new robot-assisted surgical device for use in minimal access surgery (2020)

These results demonstrate that in a simulated clinical setting, Versius can be safely used by both laparoscopically and robotically trained healthcare professionals. These results support the progression to assessment of Versius in preclinical studies.
The KOJACH food frequency questionnaire for Chaoshan, China: development and description. (2006)

This paper aims to develop a data-based Semi-Quantitative Food Frequency Questionnaire (SQFFQ) covering both urban and rural areas in the Chaoshan region of Guangdong Province, China, for the investigation of relationships between food intake and lifestyle-related diseases among middle-aged Chinese. We recruited 417 subjects from the general population and performed an assessment of the diet, using a 3-day weighed dietary record survey. We employed contribution analysis (CA) and multiple regression analysis (MRA) to select food items covering up to a 90% contribution and a 0.90 R2, respectively. The total number of food items consumed was 523 (443 in the urban and 417 in the rural population) and the intake of 29 nutrients was calculated according to the actual consumption by foods/recipes. The CA selected 233, 194 and 183 foods/recipes for the combined, the urban and the rural areas, respectively, and then 196, 157 and 160 were chosen by the MRA. Finally, 125 foods/recipes were selected for the final questionnaire. The frequencies were classified into eight categories and standard portion sizes were also calculated. For adoption of the area-specific SQFFQ, Validity and reproducibility tests are now planned to determine how the combined SQFFQ performs in actual assessment of disease risk and benefit.
Drought-inhibition of Photosynthesis in C3 Plants: Stomatal and Non-stomatal Limitations Revisited (2002)

There is a long-standing controversy as to whether drought limits photosynthetic CO2 assimilation through stomatal closure or by metabolic impairment in C3 plants. Comparing results from different studies is difficult due to interspecific differences in the response of photosynthesis to leaf water potential and/or relative water content (RWC), the most commonly used parameters to assess the severity of drought. Therefore, we have used stomatal conductance (g) as a basis for comparison of metabolic processes in different studies. The logic is that, as there is a strong link between g and photosynthesis (perhaps co-regulation between them), so different relationships between RWC or water potential and photosynthetic rate and changes in metabolism in different species and studies may be 'normalized' by relating them to g. Re-analysing data from the literature using light-saturated g as a parameter indicative of water deficits in plants shows that there is good correspondence between the onset of drought-induced inhibition of different photosynthetic sub-processes and g. Contents of ribulose bisphosphate (RuBP) and adenosine triphosphate (ATP) decrease early in drought development, at still relatively high g (higher than 150 mmol H20 m(-2) s(-1)). This suggests that RuBP regeneration and ATP synthesis are impaired. Decreased photochemistry and Rubisco activity typically occur at lower g (<100 mmol H20 m(-2) s(-1)), whereas permanent photoinhibition is only occasional, occurring at very low g (<50 mmol H20 m(-2) s(-1)). Sub-stomatal CO2 concentration decreases as g becomes smaller, but increases again at small g. The analysis suggests that stomatal closure is the earliest response to drought and the dominant limitation to photosynthesis at mild to moderate drought. However, in parallel, progressive down-regulation or inhibition of metabolic processes leads to decreased RuBP content, which becomes the dominant limitation at severe drought, and thereby inhibits photosynthetic CO2 assimilation.
Myc-Induced Liver Tumors in Transgenic Zebrafish Can Regress in tp53 Null Mutation (2015)

Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc orthologs, myca and mycb, it remains unclear about the oncogenicity of the two zebrafish myc genes. In the present study, we developed two transgenic zebrafish lines to over-express myca and mycb respectively in the liver using a mifepristone-inducible system and found that both myc genes were oncogenic. Moreover, the transgenic expression of myca in hepatocytes caused robust liver tumors with several distinct phenotypes of variable severity. ~5% of myca transgenic fish developing multinodular HCC with cirrhosis after 8 months of induced myca expression. Apoptosis was also observed with myca expression; introduction of homozygous tp53(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression. The malignant status of hepatocytes was dependent on continued expression of myca; withdrawal of the mifepristone inducer resulted in a rapid regression of liver tumors, and the tumor regression occurred even in the tp53(-/-) mutation background. Thus, our data demonstrated the robust oncogenicity of zebrafish myca and the requirement of sustained Myc overexpression for maintenance of the liver tumor phenotype in this transgenic model. Furthermore, tumor regression is independent of the function of Tp53.
Monoclonal Antibodies for the Analysis of Gossypol in Cottonseed Products (2004)

Immunogens, prepared by conjugating either (+)-gossypol or (-)-gossypol to Limulus polyphemushemolymph protein, were used for immunization in the production of monoclonal antibodies. Hybridoma were evaluated for their relative affinity to racemic gossypol, (+)-gossypol, (-)-gossypol, gossypol analogues, and their lysine derivatives. The monoclonal antibody obtained showed higher affinity to gossypol and gossypol analogues as compared to their lysine derivative counterparts. An indirect competitive enzyme-linked immunosorbent assay (ELISA) with this antibody was used to measure gossypol in 15 cottonseed meal products; the results showed good correlation with results obtained using the AOCS (free gossypol) official method (R(2) = 0.89). The direct recognition of both free gossypol and bound gossypol using this antibody will be useful for rapid screening and quality control.
Measurement of the mass difference and relative production rate of the $Ω^-_b$ and $Ξ^-_b$ baryons (2023)

The mass difference between the $Ω^-_b$ and $Ξ^-_b$ baryons is measured using proton-proton collision data collected by the LHCb experiment, corresponding to an integrated luminosity of $9 \, \text{fb}^{-1}$, and is found to be \begin{equation} m(Ω^-_b)- m(Ξ^-_b) = 248.54 \pm 0.51 \text{(stat)} \pm 0.38 \text{(syst)} \, \text{MeV}/c^2. \end{equation} The mass of the $Ω^-_b$ baryon is measured to be \begin{equation} m(Ω^-_b)= 6045.9 \pm 0.5 \text{(stat)} \pm 0.6 \text{(syst)} \, \text{MeV}/c^2. \end{equation} This is the most precise determination of the $Ω^-_b$ mass to date. In addition, the production rate of $Ω^-_b$ baryons relative to that of $Ξ^-_b$ baryons is measured for the first time in $pp$ collisions, using an LHCb dataset collected at a center-of-mass energy of $13 \, \text{TeV}$ and corresponding to an integrated luminosity of $6\,\text{fb}^{-1}$. Reconstructing beauty baryons in the kinematic region $2 &lt; η&lt; 6$ and $p_T &lt; 20\,\text{GeV}/c$ with their decays to a $J/ψ$ meson and a hyperon, the ratio \begin{equation} \frac{f_{Ω^-_b}}{f_{Ξ^-_b}}\times\frac{\mathcal{B}(Ω^-_b \to J/ψΩ^-)}{\mathcal{B}(Ξ^-_b \to J/ψΞ^-)} = 0.120 \pm 0.008 \text{(stat)} \pm 0.008 \text{(syst)}, \end{equation} is obtained, where $f_{Ω^-_b}$ and $f_{Ξ^-_b}$ are the fragmentation fractions of $b$ quarks into $Ω^-_b$ and $Ξ^-_b$ baryons, respectively, and $\mathcal{B}$ represents the branching fractions of their respective decays.
4S RNA Gene Organization in Drosophila melanogaster (1980)

Drosophila melanogaster has 300–750 genes for tRNAs per haploid genome (Ritossa et al. 1966; Tartof and Perry 1970). Since the kinetic complexity of the mixture suggests 60 different species (Weber and Berger 1976), each tRNA sequence is present an average of 5–12 times per haploid genome. We have studied the organization of the genes for several purified tRNAs. When combined with experiments using the unfractionated 4S RNA mixture, we can obtain an overall view of the organization of tRNA genes in Drosophila. A major advantage of studying Drosophila is that with the high specific activities obtained by iodination of tRNA with 125 I (Prensky 1975), the tRNA genes can be located directly on the salivary polytene chromosomes by in situ hybridization. This technique is carried out by treating chromosomes fixed to a microscope slide under conditions that will denature some of their DNA without greatly disrupting their cytological structure. Radioactive RNA is then hybridized to the chromosomes and unhybridized RNA is removed by ribonuclease treatment and extensive washing. After autoradiography, the silver grains resulting from radioactive decay localize the hybridized tRNA molecules on the cytogenetic map (Gall and Pardue 1969). By counting the number of grains at a chromosomal site on many chromosomes, one can determine the amount of RNA-DNA hybrid that is formed at that site. In this way, the rate of the in situ hybridization reaction and the amount of hybrid at saturation can be determined. Such a quantitative approach has been used successfully for the analysis...
Apposcopy: semantics-based detection of Android malware through static analysis (2014)

We present Apposcopy, a new semantics-based approach for identifying a prevalent class of Android malware that steals private user information. Apposcopy incorporates (i) a high-level language for specifying signatures that describe semantic characteristics of malware families and (ii) a static analysis for deciding if a given application matches a malware signature. The signature matching algorithm of Apposcopy uses a combination of static taint analysis and a new form of program representation called Inter-Component Call Graph to efficiently detect Android applications that have certain control- and data-flow properties. We have evaluated Apposcopy on a corpus of real-world Android applications and show that it can effectively and reliably pinpoint malicious applications that belong to certain malware families.
<title>Diode-laser-based lidars: the next generation</title> (1999)

The work on the development of compact diode laser-based lidar systems at SRI International is reviewed. Two systems, a pseudorandom modulation lidar, and a mobile remote sensor for natural gas pipeline leak detection are described in detail, and experimental results are presented. Methods to enhance signal detection by digital filtering are also reviewed.
Herpes zoster ophthalmicus and delayed ipsilateral cerebral infarction (1983)

We studied five patients who had acute cerebral infarctions 5 weeks to 6 months after herpes zoster ophthalmicus (HZO). All had infarcts of the cerebral hemisphere ipsilateral to the HZO, and one also had a cerebellar infarct. Cerebral arteriography in one patient disclosed narrowing of the middle cerebral artery, occlusion of the anterior cerebral artery ipsilateral to the HZO and narrowing of the opposite anterior cerebral artery. In another case, arteriography revealed occlusion of the distal internal carotid artery on the side of the HZO.
LncRNA BBOX1‐AS1 upregulates HOXC6 expression through miR‐361‐3p and HuR to drive cervical cancer progression (2020)

BBOX1 antisense RNA 1 facilitates CC progression by upregulating HOXC6 expression via miR-361-3p and HuR.
Electronic dispersion compensation for 10 Gigabit communication links over FDDI legacy multimode fiber (2005)

In this paper, we demonstrate measured results from two different EDC architectures, a feed forward equalizer (FFE) and a decision feedback equalizer (DFE). These are used to compensate for ISI caused by modal dispersion in highly band-limited multi-mode fiber links.
Nationwide Assessment of Trends in Choledocholithiasis Management in the United States From 1998 to 2013 (2016)

This study highlights the marked decline in the use of both open and laparoscopic CBDE in the United States as well as the benefit to the length of stay LCBDE+LC has over ERCP+LC. Despite a persistent need for CBDE and the potential benefits of LCBDE+LC over ERCP+LC for managing choledocholithiasis, if current trends continue, CBDE may be at risk of disappearing from the surgical armamentarium.