gebhart/patrepeval huggingface dataset:
PS-C27-5: ASSOCIATION BETWEEN ANKLE-BRACHIAL INDEX AND KIDNEY OUTCOMES IN PATIENTS WITH HYPERTENSION (2023)

Background: Ankle-brachial index (ABI) used for diagnosis of peripheral vascular disease is related to endothelial dysfunction. Previous studies showed the relationship between endothelial dysfunction and chronic kidney disease (CKD). Therefore, we aimed to investigate the association between ankle-brachial index and CKD progression in patients with hypertension. Methods: A total of 2,429 patients with hypertension were enrolled from the prospective observational cohort of CMERC-HI (Cardiovascular and Metabolic Disease Etiology Research Center-High Risk). Patients were classified into quartile based on ABI (A1: ABI &lt; 1.11, A2: ABI 1.11 to 1.17, A3: ABI 1.17 to 1.23, A4: ABI&gt; 1.23). Primary outcome was progression of CKD, which was composite of at least 50% decrease in estimated glomerular filtration rate (eGFR) from baseline or end stage kidney disease requiring dialysis, or incident CKD which was defined as eGFR &lt; 60 ml/min/1.73m 2 . Results: The mean age of study subjects was 60.1 ± 11.3 years and 1,346 (55.4%) were male. There were statistically significant differences in DM status (40.1%, 41.1%, 43.7%, 51.7% in A1, A2, A3, A4 group, respectively, P &lt; 0.001) among ABI quartile groups. During a median follow-up of 42.5 months, the primary outcome met the pre-specified CKD progression in 490 (20.2%). In multivariate Cox analysis, A1 and A3 group were associated with increased risk of CKD progression (HR, 2.28; 95% CI, 1.30–4.00, P = 0.004, HR, 2.22: 95% CI, 1.27–3.90, P = 0.005) compared to A2 group. Moreover, low ABI showed increased risk of CKD progression (HR, 1.57; 95% CI, 1.04–2.38; P = 0.03) after adjusting confounding factors. Conclusions: Ankle-brachial index may be an independent predictor of renal outcome in patients with hypertension.
TNFα, IL-6, miR-103a-3p, miR-423-5p, miR-23a-3p, miR-15a-5p and miR-223-3p in the crevicular fluid of periodontopathic patients correlate with each other and at different stages of the disease (2023)

Periodontitis is one of the main frequent intraoral diseases. Pathogenesis triggers are the immune responses with pro-inflammatory cytokines production and non-coding RNAs expression. The purpose of the present study was to evaluate the involvement of selected miRNAs in various stages of periodontitis and their relationship with the levels of inflammatory mediators in gingival crevicular fluid (GCF). For this study, 36 subjects (21 with periodontal disease, 15 healthy controls) were selected with an age mean of 59.1 ± 3.7 years. Clinical parameters included plaque index, gingival index, sulcus bleeding index, pocket depth, and clinical attachment level. The GCF samples were taken using capillary paper. The levels of miRNAs in GCF were estimated using a Real-Time PCR and TNFα and IL-6 levels were assessed by enzyme-linked immunosorbent assay (ELISA). The results indicated that the miRNA-103a-3p, miRNA-23a-3p, miRNA-15a-5p, and miRNA-223-3p were significantly upregulated with respect to healthy controls. Significant differences were observed for miRNA-23a-3p, miRNA-103a-3p and miRNA-423-5p levels in accord with the disease stages. Inflammatory mediators evaluated in GCF correlate well with the clinical parameters and the severity of the periodontal disease. miRNAs can represent biomarkers of disease stage and can be investigated as a possible therapeutic target, as well as levels of TNFα and IL-6 may drive the disease progression by acting as prognostic markers.
Effect of different molecular species of phosphatidylcholine on the clearance of emulsion particle lipids. (1988)

Studies were performed to assess the effect of changes in the molecular species composition of phosphatidylcholine (PC) on the clearance of emulsion particles that were made to approximate chylomicrons in size and lipid composition. Emulsions were prepared with free [14C]cholesterol, [3H]cholesteryl oleate, triolein, and one of four single PCs that differed in hydrophilic strength (as assessed by the relative rate of elution of these PCs from a reverse phase column). Emulsions were injected as an intravenous bolus into unanesthetized rats and the clearance of lipids was determined at 2-min intervals for 10 min. All emulsion lipids were cleared from the serum in parallel and in an order that closely corresponded to the relative hydrophilic strength of the particular PC that was administered. Fractional rates of clearance, calculated from log-linear plots, were 2- to 10-fold greater for all lipids for the emulsion that was made with the most hydrophilic PC compared to the least hydrophilic PC. Although hepatectomy, performed in acutely anesthetized animals, generally slowed the clearance of lipids, hepatectomy did not abolish differences in the clearance of triolein or specific PCs from emulsions prepared with the most and least hydrophilic PCs. These results indicate that a change in the composition of emulsion particle PCs, independent of any other change in the lipid composition of these particles, can significantly change the metabolism of the whole emulsion particle in the live animal. More specifically, these studies show that the rate of clearance of all emulsion lipids closely corresponds to the hydrophilic strength of the PCs that occupy the emulsion particle surface.(ABSTRACT TRUNCATED AT 250 WORDS)
Evidence for vacancy migration at 220 k in iron, given by high voltage electron microscopy (1982)

Abstract The growth of interstitial loops has been studied by 1 MeV electron microscopy in pure iron samples, irradiated and observed between 180 K and 800 K. It is shown that, below 220 K, the increase of the interstitial loop diameter obeys a tn law, with n<1 (t being the observation time). Above 220 K, a linear t law is observed. Moreover, the evolution of the loop density is strongly modified below and above 220 K. Both results lead to the conclusion that vacancies migrate at 220 K in iron. The discrepancy with previous results obtained by other physicists is explained by a model in which mobile vacancies interact with residual impurities.
Characterizing Polarization-MIMO Antennas in Random-LOS Propagation Channels (2016)

In the 5G system, we foresee the use of LOS-dominated mm-wave radio links to moving users being subject to slow fading resulting from the users' random locations and orientations. We refer to this as a random-LOS channel. MIMO processing algorithms will be used in 5G to improve performance in slow fading, similar to how they are used in Rayleigh fading. To this end, we study the probability of detection in the random-LOS channel when there are dual-polarized antennas on both sides of the link. We introduce two polarization deficiencies: the polarization non-orthogonality and the amplitude imbalance between the ports of a two-port antenna. The MIMO efficiency is evaluated as a function of these deficiencies. In the analysis, we consider the MRC algorithm for one bitstream, and the ZF and SVD algorithms for two bitstreams. We also present two analytical formulas for the MIMO efficiency that can be used to determine performance. We use the formulas on two ideally orthogonal dipoles, and show by means of coverage plots how much the 1- and 2-bitstream performances degrade due to the polarization deficiencies in off-boresight directions.
A trapped field of 14.3 T in Y–Ba–Cu–O bulk superconductors fabricated by buffer-assisted seeded infiltration and growth (2018)

The two-step top seeded infiltration and growth (TSIG) melt process has emerged as a successful and reliable technique for the fabrication of single grain (RE)Ba2Cu3O7−δ (where RE is a rare-earth element or yttrium) bulk high temperature superconductors with engineered microstructures that exhibit improved superconducting properties. In this study, the performance of these materials in large applied magnetic fields has been investigated by field cooling single grain samples in a magnetic field of 18 T. YBa2Cu3O7−δ samples processed without added Ag by the TSIG technique, in the two-sample stack configuration, trapped a magnetic field of 14.3 T at 28 K after field cooling from 100 K and subsequent removal of the applied field. This result is particularly significant in that, previously, only single grain (RE)Ba2Cu3O7−δ bulk superconductors containing Ag have been reported to be able to tolerate the large stresses on the samples inherent in the magnetisation process at large fields. The samples prepared in the present study were pre-stressed using a reinforcing stainless-steel ring, although, otherwise, they did not contain any additives, dopants or resin impregnation. The ability of samples processed by TSIG to withstand large tensile forces without Ag addition is attributed to the reduced incidence of intrinsic cracks/pores in the single grain microstructure.
Data interface + algorithms = efficient programs (2014)

Finding the right algorithm--data structure combination is easy, but finding the right data structure for a set of algorithms is much less trivial. Moreover, using the same data representation throughout the whole program might be sub-optimal. Depending on several factors, often only known at runtime, some programs benefit from changing the data representation during execution. In this position paper we introduce the idea of Just-In-Time data structures, a combination of a data interface and a set of concrete data representations with different performance characteristics. These Just-In-Time data structures can dynamically swap their internal data representation when the cost of swapping is payed back many times in the remainder of the computation. To make Just-In-Time data structures work, research is needed at three fronts: 1. We need to better understand the synergy between different data representations and algorithms; 2. We need a structured approach to handle the transitions between data representations; 3. We need descriptive programming constructs to express which representation fits a program fragment best. Combined, this research will result in a structured programming approach where separating data interface from data representation, not only improves understandability and maintainability, but also improves performance through automated transitions of data representation.
Optical switch matrix with simplified N*N tree structure (1989)

Optical switch matrices with compact size and excellent crosstalk characteristics are discussed. Novel architectures for optical switch matrices are obtained by condensing the structure of N*N tree structure. 4*4 switches fabricated on LiNbO/sub 3/ substrates are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
SQL instant reference (1993)

From the Publisher:
This latest edition of a popular guide will be useful to database programmers and administrators who need handy, updated information for (Structured Query Language) commands. Gruber is a recognized expert and author of Understanding SQL and the upcoming Mastering SQL.
The molecular aetiology of human mitochondrial myopathies (1987)

Conference Article| February 01 1987 The molecular aetiology of human mitochondrial myopathies VICTOR M. DARLEY-USMAR VICTOR M. DARLEY-USMAR 1Department of Biochemistry, The Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: August 27 1986 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1987 Biochemical Society1987 Biochem Soc Trans (1987) 15 (1): 102–103. https://doi.org/10.1042/bst0150102 Article history Received: August 27 1986 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation VICTOR M. DARLEY-USMAR; The molecular aetiology of human mitochondrial myopathies. Biochem Soc Trans 1 February 1987; 15 (1): 102–103. doi: https://doi.org/10.1042/bst0150102 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: PCr, phosphocreatine This content is only available as a PDF. © 1987 Biochemical Society1987 Article PDF first page preview Close Modal You do not currently have access to this content.
Joint Localization and Information Transfer for RIS Aided Full-Duplex Systems (2022)

In this work, we investigate a reconfigurable intelligent surface (RIS) aided integrated sensing and communication (ISAC) scenario, where a base station (BS) communicates with multiple devices in a full-duplex mode, and senses the positions of these devices simultaneously. An RIS is assumed to be mounted on each device to enhance the reflected echoes. Meanwhile, the information of each device is passively transferred to the BS via reflection modulation. We aim to tackle the problem of joint localization and information retrieval at the BS. A grid based parametric model is constructed and the joint estimation problem is formulated as a compressive sensing (CS) problem. Moreover, an expectation-maximization (EM) algorithm is applied for tuning the grid parameters to mitigate the model mismatch problem. Finally, we analyze the efficacy of various CS algorithms through the Bayesian Cramér-Rao bound (BCRB). Numerical results demonstrate the feasibility of the proposed scenario and the superior performance of the proposed EM-tuning method.
NNKTT120, an anti-iNKT cell monoclonal antibody, produces rapid and sustained iNKT cell depletion in adults with sickle cell disease (2020)

Invariant NKT (iNKT) cells can be activated to stimulate a broad inflammatory response. In murine models of sickle cell disease (SCD), interruption of iNKT cell activity prevents tissue injury from vaso-occlusion. NKTT120 is an anti-iNKT cell monoclonal antibody that has the potential to rapidly and specifically deplete iNKT cells and, potentially, prevent vaso-occlusion. We conducted an open-label, multi-center, single-ascending-dose study of NKTT120 to determine its pharmacokinetics, pharmacodynamics and safety in steady-state patients with SCD. Doses were escalated in a 3+3 study design over a range from 0.001 mg/kg to 1.0 mg/kg. Twenty-one adults with SCD were administered NKTT120 as part of 7 dose cohorts. Plasma levels of NKTT120 predictably increased with higher doses. Median half-life of NKTT120 was 263 hours. All subjects in the higher dose cohorts (0.1 mg/kg, 0.3 mg/kg, and 1 mg/kg) demonstrated decreased iNKT cells below the lower limit of quantification within 6 hours after infusion, the earliest time point at which they were measured. In those subjects who received the two highest doses of NKTT120 (0.3, 1 mg/kg), iNKT cells were not detectable in the peripheral blood for a range of 2 to 5 months. There were no serious adverse events in the study deemed to be related to NKTT120. In adults with SCD, NKTT120 produced rapid, specific and sustained iNKT cell depletion without any infusional toxicity or attributed serious adverse events. The next step is a trial to determine NKTT120’s ability to decrease rate of vaso-occlusive pain episodes.
Enhanced Activity of Selected Combinations of Bacillus thuringiensis and Beta-Exotoxin Against Fall Armyworm (Lepidoptera: Noctuidae) Larvae (1988)

Interactions between Bacillus thuringiensis Berliner and its β-exotoxin were evaluated in third- and fourth-instar Spodoptera frugiperda (J. E. Smith) in laboratory bioassays. Larvae were placed on diet containing individual or combined treatments of the two agents. The 14-d LC50 and one-half of the 14-d LC50 of B. thuringiensis for each instar were combined with five concentrations of β-exotoxin ranging from 30 to 240 μg (AI)/ml of diet for third instars and 120 to 360 μg (AI)/ml of diet for fourth instars. Synergism occurred in 9 of the 10 combinations evaluated with third instars and in 8 of the 10 combinations evaluated with fourth instars. Synergistic effects were generally masked beyond 3-7 d after exposure by high mortality caused by concentrations of β-exotoxin alone. Mean times until death were reduced by as many as 1.2 to 3.9 d in combinations that were synergistic in third instars. Combination of the LC50 of B. thuringiensis with β-exotoxinat either 180 or 360 μg (AI)/ml also reduced the time interval between exposure and death of fourth instars below those times produced by treatment with either agent alone. Other synergistic combinations in fourth instars yielded lethal times which were significantly shorter than those produced by B. thuringiensis alone. Mortality of neonates and fourth instars placed on peanut foliage treated with aqueous sprays of selected combinations of the two agents was significantly higher than mortality caused by B. thuringiensts alone but did not differ from levels resulting from treatments with β-exotoxin alone.
Protein profiling of post-prostatic massage urine specimens by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry to discriminate between prostate cancer and benign lesions (1994)

Post-prostatic massage urine specimens (PMUS) are expected to be rich in proteins originating from the prostatic acini. In this study, we created a PMUS bank consisting of 57 samples obtained from patients with biopsy-proven prostate cancer (PC) and 56 samples from subjects with biopsy-proven benign lesions to analyze protein profiles of PMUS by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS). Strong anion-exchange (Q10), weak cation-exchange (CM10) and immobilized metal affinity capture (IMAC30) ProteinChip Arrays were used for protein profiling. In PC samples, single-marker analysis detected 49 mass peaks that were significantly up-regulated and 23 peaks that were significantly down-regulated, compared with peaks obtained from benign lesion samples. To confirm reproducibility we performed additional three rounds of assay using CM10 chip with pH 4.0 binding buffer. Among these significant peaks, a peak of m/z 10788 was significant throughout all 4 rounds of assays. For hierarchical clustering analysis (HCA), we used the 72 peaks which revealed significant differences in single-marker analysis. The heat map discriminated PC from benign lesions with a sensitivity of 91.7% and a specificity of 83.3%. Therefore, SELDI-TOF MS profiling of PMUS can be applied to differentiate patients with PC from cancer-free subjects. However, further investigation is required to verify the usefulness of this method in clinical practice.
A Method to Monitor Dutasteride in Rat Plasma Using Liquid-Liquid Extraction and Multiple Reaction Monitoring: Comparisons and Validation (2014)

Three different dutasteride extraction methods were compared and a method based on liquid-liquid extraction (LLE)using methyl tert-butyl ether and methylene chloride was proved to be more effective than others for the extraction of dutasterideand finasteride, the internal standard (IS), from rat plasma. Additionally, a method composed of the LLE extraction, liquid chromatography,and multiple reaction monitoring (MRM) to target dutasteride and IS was validated by assessing specificity, linearity(r2 = 0.9993, 5 - 400 ng/mL), sensitivity (the limit of detection: 4.03 ng/mL; the limit of quantitation: 12.10 ng/mL), accuracy(intra-day: 89.4 - 105.9%; inter-day: 84.9 - 100.9%), precision (intra-day: 0.8 - 6.9%; inter-day: 2.9 - 15.9%), and recovery (84.7- 107.8%). Since the validated method was successfully applied to a pharmacokinetic study of dutasteride, it can be useful for thepharmacokinetic evaluation of newly developed dutasteride formulations.
Performance optimization for gridded-layout standard cells (2004)

The grid placement of contacts and gates enables more effective use of resolution enhancement techniques, which in turn allow a reduction of critical dimensions. Although the regular placement adds restrictions during cell layout, the overall circuit area can be made smaller and the extra manufacturing cost can be kept to the lowest by a careful selection of the grid pitch, using template-trim lithography method, allowing random contact placement in the vertical direction, and using rectangular rather than square contacts. The purpose of this work is to optimize the gridded-layout-based process. The trade-off between the layout area and manufacturing cost, and the determination of the minimum grid pitch are discussed in this paper. We demonstrate that it is a 1-D scaling instead of the conventional 2-D scaling for standard cells and the narrow MOSFETs inside after the application of the gridded layout on the contact and gate levels. The corresponding effects on circuit performances, including the leakage current, are also explored.
Gait Assessment of Pain and Analgesics: Comparison of the DigiGait™ and CatWalk™ Gait Imaging Systems (2019)

Investigation of pain requires measurements of nociceptive sensitivity and other pain-related behaviors. Recent studies have indicated the superiority of gait analysis over traditional evaluations (e.g., skin sensitivity and sciatic function index [SFI]) in detecting subtle improvements and deteriorations in animal models. Here, pain-related gait parameters, whose criteria include (1) alteration in pain models, (2) correlation with nociceptive threshold, and (3) normalization by analgesics, were identified in representative models of neuropathic pain (spared nerve injury: coordination data) and inflammatory pain (intraplantar complete Freund's adjuvant: both coordination and intensity data) in the DigiGait™ and CatWalk™ systems. DigiGait™ had advantages in fixed speed (controlled by treadmill) and dynamic SFI, while CatWalk™ excelled in intrinsic velocity, intensity data, and high-quality 3D images. Insights into the applicability of each system may provide guidance for selecting the appropriate gait imaging system for different animal models and optimization for future pain research.
The NADH oxidase from Pyrococcus furiosus (2001)

A wealth of H 2 O‐producing NADH oxidase (NOX) homologues have been discovered in the genomes of the hyperthermophilic Archaea, including two homologues in the genome of Pyrococcus furiosus which have been designated as NOX1 and NOX2. In order to investigate the function of NOX1, the structural gene encoding NOX1 was cloned from the genome of P. furiosus and expressed in Escherichia coli , and the resulting recombinant enzyme (rNOX1) was purified to homogeneity. The enzyme is a thermostable flavoprotein that can be reconstituted only with FAD. rNOX1 catalyzes the oxidation of NADH, producing both H 2 O 2 and H 2 O as reduction products of O 2 (O 2 + 1–2NADH + 1–2H + → 1–2NAD + + H 2 O 2 or 2H 2 O). To our knowledge, this is the first NADH oxidase found to produce both H 2 O 2 and H 2 O. The enzyme exhibits a low K m for NADH (&lt; 4 µ m ), and shows little or no reaction with NADPH. Transcriptional analyses demonstrated that NOX1 is constitutively expressed regardless of the carbon source and a single promoter was identified 25 bp upstream of the nox1 gene by primer extension. Although P. furiosus is a strict anaerobe, it may tolerate oxygen to some extent and we anticipate NOX1 to be involved in the response to oxygen at high temperatures.
Scanning and Transmission Electron-Microscopical Studies of the Developing Human Corneal Endothelium (1994)

*Department of Ophthalmology, Tokyo, Japan †Laboratory for Electron Microscopy, Kyorin University School of Medicine, Tokyo, Japan ‡National Children's Hospital, Tokyo, Japan