gebhart/patrepeval huggingface dataset:
The Pneumatonograph (1979)

The scale reading of the pneumatonograph (PTG) is dependent on the force of application to the cornea. Since this force is relatively greater at low intraocular pressure, the scale is compressed, yielding an overestimate of intraocular pressure in physiologic range. When the PTG is held vertically, the weight of the plunger is added to the gas propulsion force and the compression of the scale is accentuated. When a 10-g plunger load is added, as is advocated for tonography, the scale compression is further accentuated. We conclude that the PTG scale is compressed, the PTG is position-sensitive, and that the PTG is totally unsuited to tonography. The PTG is not an applanation tonometer and should not be confused with applanation tonometers.
THER-04. THE USE OF AN ADENOSINE A2 AGONIST TO IMPROVE THE PREVENTION AND TREATMENT OF BRAIN METASTASES (2019)

Abstract As systemic therapies for cancer become increasingly effective, there is generally a rise in the incidence of brain metastases as a site of first recurrence. This occurs because most antineoplastic agents do not reach the brain in therapeutic concentrations. Many approaches have been studied to improve drug distribution to the central nervous system (CNS) such as intra-arterial administration, osmotic blood-brain barrier (BBB) disruption, focused ultrasound, convection-enhanced delivery, development of CNS penetrant pro-drugs, and the use of vasoactive peptides to transiently disrupt the BBB. However, none of these has improved the prevention or treatment of CNS metastases. Regadenoson is an adenosine A2 agonist that is FDA approved for use in cardiac stress tests. In animals, it has been shown to transiently increase BBB permeability allowing high molecular weight dextran and chemotherapy to enter brain in higher concentrations. A clinical study designed to determine if regadenoson will perform similarly in humans has been CTEP approved and will soon be accruing patients through the Adult Brain Tumor Consortium. If the results are encouraging, future studies will focus on administering regadenoson concurrently with systemically administered chemotherapy in an effort to reduce the incidence of CNS metastases and to improve CNS drug delivery in patients with known brain metastases. This presentation will focus on the available pre-clinical and clinical data supporting this approach and the potential advantages and risks associated with transient BBB disruption in this setting.
Pulmonary hypertension in interstitial lung disease: an area of unmet clinical need (2022)

Pulmonary hypertension (PH) is present in an important proportion of patients with interstitial lung diseases (ILDs), encompassing a large, heterogeneous group of diffuse parenchymal lung diseases. Development of ILD-related PH is associated with reduced exercise capacity, increased need for supplemental oxygen, decreased quality of life and earlier death. Diagnosis of ILD-related PH is important and requires a high index of suspicion. Noninvasive diagnostic assessment can suggest the presence of PH, although right heart catheterisation remains the gold standard to confirm the diagnosis and to assess its severity. A comprehensive assessment is needed to make sure reversible causes of PH have been ruled out, including thromboembolic events, untreated hypoxaemia and sleep disordered breathing. The results of trials concerning pulmonary vasodilators in this particular patient group have been disappointing and, in some cases, were even associated with an increased risk of harm. Newer strategies such as medications administered through inhalation and combinations with antifibrotic drugs show encouraging results. Moreover, unravelling the role of the vasculature in the pathophysiology of pulmonary fibrosis and ILD-related PH may potentially unlock new therapeutic opportunities.
Regulation of macrophage function in tumors: the multifaceted role of NF-κB (2009)

The pivotal role of tumor-associated macrophages (TAMs) in tumor progression is now well established. TAMs have been shown to influence multiple steps in tumor development including the growth, survival, invasion, and metastasis of tumor cells as well as angiogenesis and lymphangiogenesis in tumors. The molecular circuits that polarize TAMs toward such a protumoral phenotype are now the focus of intense investigation. The transcription factor, nuclear factor-kappaB (NF-kappaB), is a master regulator of many cellular processes and been shown to regulate various pathways that impact on the function of TAMs. Much evidence for this has come from the use of elegant transgenic murine tumor models in which modification of single components of the NF-kappaB signaling pathway has been shown to regulate the pro-tumor repertoire of TAMs. Here, we outline this evidence and attempt to reconcile the various views that have emerged recently over the exact role of NF-kappaB in this phenomenon.
Novel Catalytic Hydrogenolysis of Trimethylsilyl Enol Ethers by the Use of an Acidic Ruthenium Dihydrogen Complex (1999)

The heterolytic cleavage of H(2) is the key to the novel catalytic hydrogenolysis of trimethylsilyl enol ethers catalyzed by [RuCl(eta(2)-H(2))(dppe)(2)]OTf (dppe = 1,2-bis(diphenylphosphanyl)ethane, OTf = trifluoromethanesulfonate), which results in the formation of a ketone and Me(3)SiH (see scheme). In addition, the stoichiometric, ruthenium-assisted protonation of a prochiral lithium enolate with H(2) gave a chiral ketone with high enantioselectivity (up to 75 % ee).
La transición en el campo de la salud y su impacto en enfermería (1995)

Vivimos en un proceso de cambio en el campo de la salud, en donde encontramos dos transiciones basicas; la primera es la epidemiologica y la segunda, la transicion en la atencion de la salud. En esta ultima se deben tomar en cuenta los cambios generados en materia demografica, en donde encontramos una progresion de personas mayores de 65 anos que se traduce en un envejecimiento, proximo, de la poblacion, situacion para la cual no nos hemos preparado. En este contexto es fundamental la participacion de enfermeria ya que debe desarrollar nuevas perspectivas de trabajo con mayores conocimiento, y sentido critico para enfrentarse profesionalmente a los retos venideros
Alkaloids from Solanum congestiflorum (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkaloids from Solanum congestiflorumYoshio Sato, Yoshihiro Sato, Hidehiko Kaneko, Ennio Bianchi, and Hidesato KataokaCite this: J. Org. Chem. 1969, 34, 6, 1577–1582Publication Date (Print):June 1, 1969Publication History Published online1 May 2002Published inissue 1 June 1969https://pubs.acs.org/doi/10.1021/jo01258a010https://doi.org/10.1021/jo01258a010research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Renal hemodynamic actions of lipoxins in rats: a comparative physiological study (1992)

Interactions between either the arachidonate 5-lipoxygenase (5-LO) and 15-LO or 5-LO and 12-LO can lead to the formation of lipoxins. Although the functional significance of lipoxygenase products of arachidonic acid has been recognized increasingly in glomerular inflammation, less is known regarding the specific effects of lipoxins on renal hemodynamics. Here, we examine the renal actions of lipoxin (LX) A4, LXB4, and, the recently identified 7-cis-11-trans-LXA4, which were administered into the renal artery of the euvolemic male Munich-Wistar rat. LXA4 caused increases in renal plasma flow (RPF) and glomerular filtration rate (GFR) in a dose-dependent manner. These effects were reversed during cyclooxygenase inhibition. LXB4 decreased both RPF and GFR, and its mode of action was independent of cyclooxygenase activity. 7-cis-11-trans-LXA4 decreased RPF and GFR, which effects were abolished during systemic infusion of the leukotriene D4 receptor antagonist SKF 104353. Results indicate that each of these lipoxins displays distinct hemodynamic effects via a specific mode of action on the renal vasculature of rats. Moreover, they suggest mechanisms whereby lipoxins may participate in the changes of renal hemodynamics that occur during glomerular inflammatory processes.
Optimizing Sparse Matrix-Multiple Vectors Multiplication for Nuclear Configuration Interaction Calculations (2014)

Obtaining highly accurate predictions on the properties of light atomic nuclei using the configuration interaction (CI) approach requires computing a few extremal Eigen pairs of the many-body nuclear Hamiltonian matrix. In the Many-body Fermion Dynamics for nuclei (MFDn) code, a block Eigen solver is used for this purpose. Due to the large size of the sparse matrices involved, a significant fraction of the time spent on the Eigen value computations is associated with the multiplication of a sparse matrix (and the transpose of that matrix) with multiple vectors (SpMM and SpMM_T). Existing implementations of SpMM and SpMM_T significantly underperform expectations. Thus, in this paper, we present and analyze optimized implementations of SpMM and SpMM_T. We base our implementation on the compressed sparse blocks (CSB) matrix format and target systems with multi-core architectures. We develop a performance model that allows us to understand and estimate the performance characteristics of our SpMM kernel implementations, and demonstrate the efficiency of our implementation on a series of real-world matrices extracted from MFDn. In particular, we obtain 3-4 speedup on the requisite operations over good implementations based on the commonly used compressed sparse row (CSR) matrix format. The improvements in the SpMM kernel suggest we may attain roughly a 40% speed up in the overall execution time of the block Eigen solver used in MFDn.
Preparing High-Purity Lithium Hydroxide Monohydrate by the Electrochemical Conversion of Highly Soluble Lithium Salts (2020)

A series of studies on the preparation and reproduction of a solution of lithium sulfate obtained from technical salts Li2CO3 and Li2SO4 ⋅ H2O has been performed for the electrochemical conversion of lithium sulfate to hydroxide. High-purity lithium hydroxide monohydrate has been shown to be prepared from conversion alkali, namely, a LiOH solution. These studies are the basis of a waste-free technology for producing high-purity lithium hydroxide monohydrate from technical salts of lithium carbonate and sulfate.
New Approach on Multimode Polymer Optical Waveguides Evaluations (2013)

We designed and realized multimode polymer optical waveguides on the chips. They were fundamental functional structures and we fabricated them by using simple techniques. We have developed new approach that is simple and nondestructive for multimode polymer optical waveguide evaluations. We examined reliability of the proposed approach by measuring the optical parameters of the realized devices. We have also evaluated the modes distribution affected by inserting additional fibers to the input launch configurations. We realized an optimal-filled input launch by implementing the encircled flux ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">EF</i> ) category for 50 μm core <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GI</i> input fiber proposed by the International Electrotechnical Commission ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">IEC</i> ). We are successful to achieve insertion loss ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">IL</i> ) variation of less than 5% for the waveguides fabricated on top of different substrates.
Theoretical Investigations on Chalcogen−Chalcogen Interactions:  What Makes These Nonbonded Interactions Bonding? (2006)

To understand the intermolecular interactions between chalcogen centers (O, S, Se, Te), quantum chemical calculations on pairs of model systems were carried out. For the oxygen derivatives, one of the components of the supermolecules consists of dimethyl ether, while the second component is either dimethyl ether (1) or ethynyl methyl ether (2) or methyl cyanate (3). The model calculations were also extended to the sulfur (4-6), selenium (7-9), and tellurium congeners (10-12). The MP2/SDB-cc-pVTZ, 6-311G level of theory was used to derive the geometrical parameters and the global energies of the model systems. A detailed analysis based on symmetry adapted perturbation theory (SAPT) reveals that induction and dispersion forces contribute to the bonding in each case. For 1-3 the electrostatic energy also contributes to the intermolecular bonding, but not for 4-12. The NBO analysis reveals that the interaction in the dimers 1-3 is mainly due to weak hydrogen bonding between methyl groups and chalcogen centers. Similar hydrogen bonding is also found in the case of 4 and to a lesser extent in 5 and 7. For the aggregates with heavier centers the chalcogen-chalcogen interaction dominates, and hydrogen bonding only plays a minor role. Electron-withdrawing groups on the chalcogen centers increase the interaction energy and reduce the intermolecular distance dramatically. The one-electron picture of an interaction between the lone pair of the donor and the chalcogen carbon sigma orbital allows a qualitatively correct reproduction of the observed trend.
Diode-seeded nanosecond Yb-doped fiber amplifier operating at the repetition rate up to 500 kHz (2008)

The paper presents a laser system developed in MOFPA (Master Oscillator Fiber Power Amplifier) configuration. A pulsed single-mode laser diode operating at the wav elength of 1060-nm was used as a seed. An ytterbium-doped double-clad Large Mode Area fiber pumped by the radiation of 978-nm played a role of an active medium. The developed laser system ge nerated a pulse train with duration ranging from about 11 ns to 200 ns at the repetition rate up to 500 kHz , regulated independently of the system gain. The maximum amplification of the fiber amplifi er was 32 dB.
Oral sorbents for small, charged uremic toxins, and carbon block for regeneration of dialysate: Fourth down and long (2022)

Complexities of sorbent regeneration of dialysate led me to look at other ways to use sorbents to remove uremic toxins. An oral sorbent containing cation and anion exchangers showed effective binding of potassium, phosphate, sodium, hydrogen, and ammonium (from urea) in vitro. Animal studies are ongoing. Carbon block columns can effectively bind organic and middle molecules toxins from the dialysate. Together, these two technologies have the potential to greatly simplify dialysis for end-stage renal disease patients.
Nitrate‐Selective Solid Contact Electrodes with Poly(3‐octylthiophene) and Poly(aniline) as Ion‐to‐Electron Transducers Buffered with Electron‐Ion‐Exchanging Resin (2006)

Abstract The study of nitrate selective solid contact electrodes containing poly(3‐octyl)thiophene and poly(aniline) demonstrated the advantage of buffering the transducing layer with electron‐ion‐exchanging resin. The buffering, in particular in the case of poly(aniline) doped with nitrate anions ensured significant improvement of the long‐term stability and piece‐to‐piece reproducibility of the electrode potentials. It is shown that the redox species causes potential drift after a long time delay, probably because of slow diffusion in the membrane bulk.
Clearance and localization of intravitreal liposomes in the aphakic vitrectomized eye. (1987)

The authors have examined the fate of intravitreally injected liposomes in the aphakic, vitrectomized eye of the rabbit. Liposomes labelled with 125[I]-p-hydroxybenzimidylphosphatidylethanolamine were eliminated rapidly from the intraocular fluid. Nonetheless, a significant fraction of these liposomes were found to bind to various ocular tissues including the retina, iris, sclera, and cornea. Ultrastructural studies with gold colloid-loaded liposomes revealed that retinal bound liposomes were attached to the inner limiting lamina but did not penetrate to the internal cells of the retina. Epiretinal cells bound and internalized gold colloid-loaded liposomes suggesting that these cells may be very sensitive to liposome mediated drug delivery.
Lagged Co-Occurrence Analysis reveals gender differences of co-occurrence patterns in personal narratives (2004)

Gender difference has long been the focus of extensive psychological as well as linguistic research. Differences in behavior, attitudes, symptoms and other psychological and sociological characteristics have been extensively observed and documented (for reviews see e.g. Kessler, 1994; Brannon, 2002). Viewing language as one such behavior, gender differences in naturallyoccurring speech have long been discussed in the linguistic research literature (for reviews see e.g. Haas, 1979; Mulac and Lundell, 1986). Gender difference in language use and comprehension has even become a popular topic of discussion in the non-professional readership as well (Tannen, 1991, 1994; Pease and Pease, 2001). Most empirical research examining the differences in language use across the gender line can be categorized into 2 major divisions: form (including style and grammar), and content, usually practiced as content analysis. Research on the different speech style that characterizes women's speech has found differences in the way in which women convey authority (e.g. Levenston, 1969; Tannen, 1994; Mott and Petrie, 1995), uncertainty (e.g. Lakoff, 1975, 1977; McMillan, 1977; Mulac et al., 1998), politeness (e.g. Brown and Levinson, 1987; Holmes, 1995) and disagreements (e.g. Carli, 1990; McLachlan, 1991), as well as other complex pragmatic tasks. Content analysis studies, on the other hand, rely on systematic categorization of the words uttered by the informant. This is usually performed either using computer software (e.g. Stone, 1966), or trained raters (e.g. Gottschalk, 1969). Only a few studies have quantitatively examined gender differences through the content analysis of male and female speakers (e.g. Gieser et al., 1959; Mulac and Lundell, 1986; Ries, 1999). These studies have consistently found that women tend to use more emotional words (e.g. Mulac et al., 1990; Anderson and Leaper, 1998), adverbs (Mondorf, 2002;
Progression of a Weakly Tumorigenic Mouse Fibrosarcoma at the Site of Early Phase of Inflammation Caused by Plastic Plates (1993)

To elucidate tumor progression-enhancing factor(s), we examined the effects of host inflammation and host immunological status on in vivo tumor progression. One x 10(4) cells of QR clones (QR-32, -20 and -18), regressor tumor clones of 3-methylcholanthrene-induced fibrosarcoma, were unable to grow when injected s.c. into C57BL/6 mice in cell suspension form. However, QR clones grew and were lethal when s.c. implanted, attached to plastic plates. Furthermore, the tumor lines (QRpP) obtained from the tumors which had arisen from the plate-attached QR-32 clone cells no longer required plastic plates for their growth in normal mice, and had acquired stable malignant phenotypes. Although QR-32 cells became lethal when injected at the site of plastic plate implantation 1, 5 and 10 days before tumor injection, few tumors developed when plastic plates had been implanted 20 or 30 days before tumor injection. We established culture clones from the tumors arising in normal mice and mice immunosuppressed by irradiation. Clones derived from the tumors which had arisen in normal mice after implantation with plastic plates were lethal when re-implanted in normal mice (71%). On the other hand, clones derived from the tumors that arose in irradiated mice with or without plastic plates were lethal in only a few normal mice, when re-implanted (20 and 8%, respectively). These results indicate that QR clone cell progression is enhanced by the early phase of inflammation at the site of plastic plate implantation and that the progression-enhancing activity of co-implantation with a plastic plate is inhibited by previous whole-body irradiation of hosts.
Transition metal chelate-fulleride compounds: Electrocrystallization of semiconducting (Ru(bpy)3)(C60)2. Interim report (1992)

Two recent breakthroughs in the chemistry of fullerenes have provided the impetus for using fullerenes to prepare novel solid state materials: a method to produce large amounts of C60 and related materials, and the discovery of superconductivity in fullerides of K, Rb and Cs. The superconducting alkali metal compounds, which appear to contain C60(3-), show a trend toward higher transition temperatures upon increasing the size of the unit cell up to the composition Rb2CsC60. We thought that the synthesis of new compounds of reduced fullerenes with large cations might produce materials with interesting properties. Transition metal complexes with neutral chelating ligands (e.g. Ru(bpy)3(2+), where bpy = 2,2' bipyridine) seemed like good candidates as cations for C60 salts. Such complex cation have a rich electrochemistry and photochemistry. Furthermore, the electronic and optical properties can be varied via ligand and metal substitution, providing a route for tuning the properties of the new materials.
Spectrophotometric detection of ion pair–crown ether complexes of alkali picrates (1974)

Bathochromic shifts observed in the optical spectra of alkali picrates in tetrahydrofuran on addition of crown ethers and bis-(crown ethers) can be rationalized in terms of tight and loose ion pair-crown ether complexes.
Microstructures of thin sputtered amorphous Tb0.26Fe0.74 and polycrystalline Fe films (1986)

A transmission electron microscope was used to characterize the microstructure of Te0.26Fe0.74 and Fe films obtained by magnetron and dc diode sputtering techniques. The films obtained by magnetron sputtering were very smooth, whereas those by diode sputtering were not smooth but islandlike, similar to the columnar structure. The microstructures were further examined by varying the pressure of argon gas. In both sputtering systems, an increase in the pressure promotes a tendency of the columnar structure to form.