gebhart/patrepeval huggingface dataset:
VITA (2005)

As technology scales down, timing verification of digital integrated circuits becomes an extremely difficult task due to statistical variations in the gate and wire delays. Statistical timing analysis techniques are being developed to tackle this important problem. In this paper, we propose a new framework for handling variation-aware interconnect timing analysis in which the sources of variation may have symmetric or skewed distributions. To achieve this goal, we express the resistance and capacitance of a line in canonical first order forms and then use these to compute the circuit moments. The variational moments are subsequently used to compute the interconnect delay and slew at each node of an RC tree. For this step, we combine known closed-form delay metrics such as Elmore and AWE-based algorithms to take advantage of the efficiency of the first category and the accuracy of the second. Experimental results show an average error of 2% for interconnect delay and slew with respect to SPICE-based Monte Carlo simulations.
Fundamental Analysis of Automatic Excavation (1995)

Automatic excavation has recently gained an increasing attention in industries such as construction, mining, and road works because of the need for cost-effectiveness as well as better safety for workers. Also, in remote work applications, like terrestrial sampling and cleaning of hazardous waste, there is a great need for automated excavation. In this paper, first a review and categorization of the previous work on the subject is carried out based on different aspects of the work associated with automating such a process. Then the nature of the excavation process is analyzed and the way it may be controlled is investigated.
Data-Driven Modelling of Polyethylene Recycling under High-Temperature Extrusion (2022)

Two main problems are studied in this article. The first one is the use of the extrusion process for controlled thermo-mechanical degradation of polyethylene for recycling applications. The second is the data-based modelling of such reactive extrusion processes. Polyethylenes (high density polyethylene (HDPE) and ultra-high molecular weight polyethylene (UHMWPE)) were extruded in a corotating twin-screw extruder under high temperatures (350 °C < <i>T</i> < 420 °C) for various process conditions (flow rate and screw rotation speed). These process conditions involved a decrease in the molecular weight due to degradation reactions. A numerical method based on the Carreau-Yasuda model was developed to predict the rheological behaviour (variation of the viscosity versus shear rate) from the in-line measurement of the die pressure. The results were successfully compared to the viscosity measured from offline measurement assuming the Cox-Merz law. Weight average molecular weights were estimated from the resulting zero-shear rate viscosity. Furthermore, the linear viscoelastic behaviours (Frequency dependence of the complex shear modulus) were also used to predict the molecular weight distributions of final products by an inverse rheological method. Size exclusion chromatography (SEC) was performed on five samples, and the resulting molecular weight distributions were compared to the values obtained with the two aforementioned techniques. The values of weight average molecular weights were similar for the three techniques. The complete molecular weight distributions obtained by inverse rheology were similar to the SEC ones for extruded HDPE samples, but some inaccuracies were observed for extruded UHMWPE samples. The Ludovic<sup>®</sup> (SC-Consultants, Saint-Etienne, France) corotating twin-screw extrusion simulation software was used as a classical process simulation. However, as the rheo-kinetic laws of this process were unknown, the software could not predict all the flow characteristics successfully. Finally, machine learning techniques, able to operate in the low-data limit, were tested to build predicting models of the process outputs and material characteristics. Support Vector Machine Regression (SVR) and sparsed Proper Generalized Decomposition (sPGD) techniques were chosen to predict the process outputs successfully. These methods were also applied to material characteristics data, and both were found to be effective in predicting molecular weights. More precisely, the sPGD gave better results than the SVR for the zero-shear viscosity prediction. Stochastic methods were also tested on some of the data and showed promising results.
Charge sensitive amplifier study in 2um FD SOI CMOS (2011)

A charge sensitive amplifier in 2um Fully Depleted (FD) Silicon on Insulator (SOI) CMOS technology has been designed according to the specifications of a silicon radiation detector. A set of five amplifiers has been produced in order to study the noise dependence on the input transistor size. Initial DC measurements are presented to validate the simulations.
Assessing immune function in adult bronchiectasis (2006)

Bronchiectasis is characterized by chronic airway infection and damage and remains an important health problem. Recent literature has emphasized the role of host defence and immune deficiency in the pathogenesis of bronchiectasis, but there have been few studies of immune function in adult bronchiectasis. A comprehensive screen of immune function was conducted in 103 adult patients with bronchiectasis, encompassing full blood examinations, immunoglobulins and IgG isotypes, complement levels, lymphocyte subsets and neutrophil function. Full blood examinations were normal in this cohort, as were complement levels. Statistical analysis confirmed that a significant number of subjects had low levels of IgG3 (13 patients), B cell lymphocytes (six patients) and T helper cell lymphocytes (seven patients) when compared with controls (P<0.05). The most common abnormality was found with testing of the neutrophil oxidative burst. All subjects had a normal neutrophil phagocytic function but 33 of the subjects had an oxidative burst that was below the normal range (P<0001). Almost half the group (45 subjects) had abnormally low levels of one of these four parameters. The findings of low B cells, Th cells and oxidative burst in bronchiectasis are novel. The results emphasize the importance of immune function assessment for adult bronchiectasis.
Multi-omics analysis of early leaf development in Arabidopsis thaliana (2021)

The growth of plant organs is driven by cell division and subsequent cell expansion. The transition from proliferation to expansion is critical for the final organ size and plant yield. Exit from proliferation and onset of expansion is accompanied by major metabolic reprogramming, and in leaves with the establishment of photosynthesis. To learn more about the molecular mechanisms underlying the developmental and metabolic transitions important for plant growth, we used untargeted proteomics and metabolomics analyses to profile young leaves of a model plant <i>Arabidopsis thaliana</i> representing proliferation, transition, and expansion stages. The dataset presented represents a unique resource comprising approximately 4,000 proteins and 300 annotated small-molecular compounds measured across 6 consecutive days of leaf growth. These can now be mined for novel developmental and metabolic regulators of plant growth and can act as a blueprint for studies aimed at better defining the interface of development and metabolism in other species.
Developing Midlevel Leadership Teams (2023)

The midlevel leadership team members must view themselves as vital contributors to the direction of the college. The vision of the college should inform the curriculum for the midlevel leadership development program. The professional development academy was an organized leadership development program for midlevel managers. The American Association of Community College separates leadership competencies into five broad categories: organizational strategy, communication, collaboration, fund-raising and finance, and community college advocacy. Conveners of develop-your-own programs may start with a plan but can allow flexibility to modify it based on input provided from the participants. Aligning everything with the institution's vision is key to the success of developing the team and moving from strategy development to execution of the vision. External pressures, including demands for higher levels of accountability from accrediting bodies and state agencies, have created a need for new skill sets in midlevel leadership teams.
The journey into work – an innovative approach to tackling long‐term youth unemployment (2000)

Considers the background to various welfare‐to‐work interventions and introduces the conceptual framework of an integrative person‐centred approach, which has been piloted in the CASEPT (Computer Aided Selection & Evaluation Psychometric Test) programme and achieved significantly positive results. The CASEPT programme provides a radical and innovative way of working with long‐term unemployed young people that utilises an integrative person‐centred approach. It recognises that the long‐term unemployed may be traumatised by life’s negative experiences and that an integrative person‐centred approach is the most viable way to move them from helplessness to empowerment.
Partially-Blind Estimation of Reciprocal Channels for AF Two-Way Relay Networks Employing M-PSK Modulation (2012)

We consider the problem of channel estimation for amplify-and-forward two-way relays assuming channel reciprocity and M-PSK modulation. In an earlier work, a partially-blind maximum-likelihood estimator was derived by treating the data as deterministic unknowns. We prove that this estimator approaches the true channel with high probability at high signal-to-noise ratio (SNR) but is not consistent. We then propose an alternative estimator which is consistent and has similarly favorable high SNR performance. We also derive the Cramer-Rao bound on the variance of unbiased estimators.
Near‐infrared spectroscopy correlates with continuous superior vena cava oxygen saturation in pediatric cardiac surgery patients (2008)

The continuous measurement of ScvO(2) values obtained by the Pediasat may provide useful information about the metabolic conditions of the brain during cardiac operations in pediatric patients if considered as percentage changes. Absolute values of ScvO(2) tend to overestimate the correspondent rSO(2) values.
Abstract #1572: Pharmacokinetics of a novel fumagillol conjugate XMT-1107 in the rat (2009)

XMT-1107 is a novel polymer fumagillol derivative, comprised of the small molecule XMT-1191 conjugated to a 70 kDa biodegradable, hydrophilic polyacetal , poly(1-hydroxymethylethylene hydroxylmethylformal) (PHF). XMT-1191, the primary release product of XMT-1107, induces antiangiogenic activity by irreversible inhibition of methionine aminopeptidase 2 and exhibits antiproliferative activity at nanomolar concentrations in a HUVEC cell assay. The conjugated drug, XMT-1107, demonstrates improvement in antitumor activity in tumor xenograft models compared to either unconjugated XMT-1191 or the well-known fumagillol derivative TNP-470. In this study we evaluated the pharmacokinetics (PK) of XMT-1107 and its release product XMT-1191 in rat and demonstrated that the selected polymer delivery system extends exposure to conjugated drug and the corresponding drug release product, XMT-1191, while significantly (> 500 fold) reducing XMT-1191 plasma C max . XMT-1107 and XMT-1191 were administered to Sprague-Dawley rats intravenously (iv) as a single bolus at 50.6 mg XMT-1191 equivalents/kg. Blood was collected over 48 hours after administration to determine the highest concentration and extent of exposure (C max and AUC), volume of distribution (Vd), clearance (CL), and elimination half-life (t 1/2 ). The conjugated and released (free) XMT-1191 in plasma was analyzed by LC-MS/MS. PK of XMT-1107 was monoexponential, with very little to no distribution phase. After immediate C max (1.1 mg XMT-1191 equivalent/mL), XMT-1107 plasma concentrations declined with a t 1/2 of 22 hours. Observed AUC 0-48 and AUC 0-inf values were 19,200 hr*\#956;g/mL and 26,700 hr*\#956;g/mL, respectively. XMT-1107 values for CL and Vd were low (1.9 mL/hr and 58 mL respectively) indicating slow renal clearance, low RES uptake and primarily vascular localization of the conjugated drug. The released XMT-1191 exhibited release-dependent PK with an apparent plasma t 1/2 and duration of exposure in good agreement with those of the parent conjugate. The exposure to released XMT-1191 represented \#8804; 0.2 % of the corresponding XMT-1107 AUC values. The comparison of conjugate released XMT-1191 PK with data obtained for XMT-1191 dosed as an iv bolus indicated that conjugation to the polymer reduces C max and prolongs the duration of exposure to XMT-1191 without substantial difference in overall AUC. Our data suggest that the slow rate of release of XMT-1191 from the polymer conjugate XMT-1107, rather than the PK behavior of XMT-1191 itself, is an important factor contributing to the PK profiles of both XMT-1107 and its release product XMT-1191 in rat plasma. Overall, XMT-1107 provides a water-soluble carrier stabilized form of XMT-1191, which combines extended exposure to drug at reduced circulating concentration of free XMT-1191 with the potential advantages associated with polymer-based targeting of tumor neovasculature. Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 1572.
Genotype 2a Hepatitis C Virus Subgenomic Replicon Can Replicate in HepG2 and IMY-N9 Cells (2004)

A hepatitis C virus genotype 2a subgenomic replicon, JFH-1 replicon, was previously established using the consensus sequence of clone JFH-1 from a patient with fulminant hepatitis and, in a previous report, was indicated to replicate efficiently in Huh7. Here the replication of JFH-1 replicon was tested in HepG2, a human hepatocyte-derived cell line, and in IMY-N9, a cell line developed by fusing human hepatocytes and HepG2 cells. Following transfection with in vitro transcribed replicon RNA and selection by cultivation with G418, colonies formed in both cell lines although at efficiencies substantially lower than those of Huh7. The H2476L mutation identified in the Huh7 replicon in our previous study increased the colony formation efficiencies of the JFH-1 replicon in HepG2 and IMY-N9 cells. Higher amounts of replicon RNA were detected in IMY-N9 clones than in HepG2 clones by real time detection reverse transcription-PCR, and replicon RNA replication and viral protein expression were confirmed by Northern and Western blotting in isolated clones. Sequencing of replicon RNAs revealed that mutations found in hepatitis C virus-derived regions were not identical and that two of nine HepG2 clones and three of nine IMY-N9 clones had no or one synonymous mutation. This system with the JFH-1 replicon and three cell lines is useful not only for estimating the cellular factors affecting viral activity but also for clarifying the common gene response of the host.
Long-range attraction of an ultrarelativistic electron beam by a column of neutral plasma (2016)

We report on the experimental observation of the attraction of a beam of ultrarelativistic electrons towards a column of neutral plasma. In experiments performed at the FACET test facility at SLAC we observe that an electron beam moving parallel to a neutral plasma column, at an initial distance of many plasma column radii, is attracted into the column. Once the beam enters the plasma it drives a plasma wake similar to that of an electron beam entering the plasma column head-on. A simple analytical model is developed in order to capture the essential physics of the attractive force. The attraction is further studied by 3D particle-in-cell numerical simulations. The results are an important step towards better understanding of particle beam–plasma interactions in general and plasma wakefield accelerator technology in particular.
A PLUG & PLAY CONCEPT FOR IEC 61850 IN A SMART GRID (2011)

This paper presents a Plug & Play concept for IEC 6 in a Smart Grid. Since the traditional engineering process of the standard is outlined for substation automati on, it shows some weaknesses in other Smart Grid applicati ons like the integration of distributed energy resource s. To overcome these weaknesses IEC 61850 has to support the Plug & Play function. After justifying this assumpt ion, we describe a Plug & Play reference architecture based on well-known protocols like UPnP and DPWS. We study h ow the concepts of the reference architecture can be a pplied to IEC 61850. Several changes and additions, e.g. with respect to discovery mechanisms, are proposed enabl ing IEC 61850 to support Plug & Play for Smart Distribu tion.
Scanning mirror for optical coherence tomography using an electrostatic MEMS actuator (2003)

This paper describes a compact micromirror device for use in the scanning arm of an optical coherence tomography (OCT) system using an electrostatic micromachine (MEMS) actuator. Optical deflections of these MEMS mirror devices range from 18 degrees at low frequencies to more than 140 degrees near the resonant frequencies of the structures (30-60 Hz). These devices consist of gold plated silicon mirrors resting on polyimide tables that tilt on 3 &mu;m thick torsion hinges when pulled on by the micromachine (MEMS) actuator, the integrated force array (IFA). The IFA is a thin (2.2 &mu;m) polyimide membrane consisting of hundreds of thousands of micron scale deformable capacitors, and contracts with strains up to 20% and forces up to 13 dynes. The support structures, hinges, and actuators are fabricated from polyimide on silicon wafers using photolithography, leading to the possibility for integrated fabrication of the devices resulting in highly repeatable and inexpensive scanning arms. These devices were inserted into the scanning arm of a high speed OCT imaging system to acquire <i>in vitro</i> images of porcine eye and colon tissue and <i>in vivo</i> images of human skin at frame rates from 4-8 Hz.
Stable hydroxycarbonium ions derived from stereoisomeric spirocyclopropane-anthrones (1970)

Protonation of stereoisomeric spirocyclopropane-anthrones in 96% D2SO4 led to stable hydroxy-carbonium ions whose n.m.r. spectra and retention of stereochemistry upon deprotonation were consistent with static bridged ions rather than equilibrating open-ring mixtures.
615 Effect of small addition of Zr on the strength and electrical conductivity of Al-Cu wire (2007)

In recent years, lighter materials are prone to be demanded particularly in the field of transportation as a solution of global environment problems. Because aluminum has a relatively small density and high electric conductivity, 30% and 60% of those of copper, respectively, replacing wiring cable materials from copper to aluminum cause weight saving at the same electric conductivity level. However, the strength of aluminum must be improved by alloying etc. keeping its high electric conductivity when applied to the actual wire cables. Specimens of Al- l.lmass%Cu alloys with Zr up to 0.2mass% were induction-melted, continuously cast into a round bar of 8mm in diameter and then cold-drawn. Tensile test and assessment of the electric conductivity were carried out. As a result, tensile properties and work hardening behavior were not affected seriously by the Zr addition, while electrical conductivity was significantly decreased as the addition amount increased.
High-level synthesis under I/O Timing and Memory constraints (2006)

The design of complex Systems-on-Chips implies to take into account communication and memory access constraints for the integration of dedicated hardware accelerator. In this paper, we present a methodology and a tool that allow the High-Level Synthesis of DSP algorithm, under both I/O timing and memory constraints. Based on formal models and a generic architecture, this tool helps the designer to find a reasonable trade-off between both the required I/O timing behavior and the internal memory access parallelism of the circuit. The interest of our approach is demonstrated on the case study of a FFT algorithm.
The Germine-Isogermine-Pseudogermine Isomerizations1 (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Germine-Isogermine-Pseudogermine Isomerizations1S. Morris Kupchan, Mary Fieser, C. R. Narayanan, Louis F. Fieser, and Josef FriedCite this: J. Am. Chem. Soc. 1955, 77, 22, 5896–5898Publication Date (Print):November 1, 1955Publication History Published online1 May 2002Published inissue 1 November 1955https://pubs.acs.org/doi/10.1021/ja01627a035https://doi.org/10.1021/ja01627a035research-articleACS PublicationsRequest reuse permissionsArticle Views39Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Two-dimensional All-Optical Routing and Switching in Laser-Written Waveguide Arrays (2011)

We present a comprehensive experimental analysis of the switching and routing behaviour of light in two-dimensional laser-written waveguide arrays. Exploring the unique properties of such systems, we propose different networking schemes for sophisticated logical operations.
An Experimental Robot Load Identification Method for Industrial Application (2002)

In this paper, we discuss a new experimental robot load identification method that is used in industry. The method is based on periodic robot excitation and the maximum likelihood estimation of the parameters, techniques adopted from Swevers et al. (1997 IEEE Transactions on Robotics and Automation 13(5):730—740). This method provides: (1) accurate estimates of the robot load inertial parameters; and (2) accurate actuator torque predictions. These are both essential for the acceptance of the results in an industrial environment. The key element to the success of this method is the comprehensiveness of the applied model, which includes, besides the dynamics resulting from the robot load and motor inertia, the coupling between the actuator torques, the mechanical losses in the motors and the efficiency of the transmissions. Accurate estimates of the robot link and motor inertial parameters, which can be considered identical for all robots of the same type, are obtained from separate experiments (see Swevers et al.), and used as a priori knowledge for the robot load identification. We present experimental results on a KUKA industrial robot equipped with a calibrated test load.
The THRombolysis and STatins (THRaST) study (2013)

Statin use in the acute phase of stroke after IV thrombolysis may positively influence short- and long-term outcome.