gebhart/patrepeval huggingface dataset:
A Pharmacokinetic Study of Carvedilol (BM 14.190) in Elderly Subjects: Preliminary Report (1987)

Summary: This study in eight elderly male volunteers examined the pharmacokinetics of carvedilol following intravenous and oral administration of the drug. Blood pressure and pulse rate responses were also determined and compared with those to labetalol. Carvedilol was absorbed rapidly after oral administration with a bioavailability of approximately 45% and obeyed linear pharmacokinetics over the dose range 25–50 mg. The terminal elimination half-life varied between 5 and 14 h. Administration of the drug with food did not alter the bioavailability or kinetic handling of carvedilol. The hemodynamic responses to carvedilol followed the same pattern as those to labetalol. There was a rapid dose-related fall in blood pressure maximal after 4–5 h and disappearing by 12 hours. Tachycardia that was evident on placebo was inhibited by both drugs. Postural hypotension and dizziness were also apparent with both drugs.
Evaluation of Ferroelectric Properties of Piezoelectric Ceramics Based on Crystallographic Homogenization Method and Crystal Orientation Analysis by SEM EBSD Technique (2005)

Macroscopic ferroelectric properties of piezoelectric polycrystals are strongly affected by microscopic non-homogeneous crystal structure. In our previous study, a multi-scale finite element procedure based on crystallographic homogenization method has been developed to predict macroscopic properties by considering microscopic crystal morphology. In this study, a crystal orientation distribution of polycrystalline barium titanate has been measured by SEM·EBSD technique, and it has been introduced to the microscopic finite element model, which satisfies the periodicity. As the prediction of macroscopic properties depends on the sampling conditions of the measured crystal orientations, the effects of number of sampling points and sampling area have been investigated.Additionally, the influence of dispersion of crystal morphology on macroscopic ferroelectric properties has been discussed.
Evaluation of Novation Contract (1994)

Novation contract is a relatively new procurement method employed in the construction industry. It attempts to gain the optimum expertise of all parties involved at various stages of the project life cycle. In this system, the client engages design consultants to create a suitable design proposal. Before the design is fully documented, the proposal is tendered out to selected contractors who work out the remaining design with the consultants and tender for construction. The winning contractor accepts responsibility for the full design and construction of the building and is required to hire the client's design consultants. This paper compares and contrasts novation contract with traditional procurement system. It analyses the similarities and differences in organisational structure, roles and the risk allocation of the parties involved. The analysis will enable the client to evaluate the advantages and disadvantages of novation in comparison with alternative procurement system. The industry's perception of novation contracts is also explored by a series of structured interviews.
Histological Presence of Viable Prostatic Glands on Routine Biopsy Following Cryosurgical Ablation of the Prostate (1997)

Cryosurgical ablation of the prostate has the ability to ablate prostatic tissue completely, thus rendering it free of glandular elements as determined by biopsy. Increasing PSA can indicate residual glandular elements. Increases in unaltered prostatic glandular epithelial elements with time are not paralleled by increased rates of local disease recurrence. undetectable serum PSA has a low risk of residual unaltered prostatic glandular epithelial elements and localized carcinoma. Results as measured by unaltered prostatic glandular epithelial elements and PSA improve with the surgical experience.
KTP laser assisted excision of glomus tympanicum (1998)

A 39-year-old female with a two-year history of mild hearing loss and discomfort on air flight descent was found to have a pulsatile mass behind an intact tympanic membrane. A suspected diagnosis of glomus tympanicum was confirmed by computed tomography (CT) scan imaging. The lesion filled the mesotympanum and hypotympanum but the jugular bony plate was intact, confirming the tympanic site of the lesion. This very vascular tumour was exposed by a tympanomeatal flap and the KTP laser used to shrink and coagulate the tumour progressively with minimal haemorrhage and blood loss. Complete excision of the lesion was achieved without the need for bony removal, and with minimal blood loss. The use of the KTP laser to coagulate this vascular lesion allowed safe removal of the tumour and avoided the need for extended facial recess or hypotympanotomy surgery.
Synthesis and pyrolytic transformations of 7-methylenebicyclo[4.1.0]hept-2-ene and bicyclo[6.1.0]nona-1,6-diene (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and pyrolytic transformations of 7-methylenebicyclo[4.1.0]hept-2-ene and bicyclo[6.1.0]nona-1,6-dieneW. E. Billups, K. H. Leavell, W. Y. Chow, and E. S. LewisCite this: J. Am. Chem. Soc. 1972, 94, 5, 1770–1771Publication Date (Print):March 1, 1972Publication History Published online1 May 2002Published inissue 1 March 1972https://pubs.acs.org/doi/10.1021/ja00760a072https://doi.org/10.1021/ja00760a072research-articleACS PublicationsRequest reuse permissionsArticle Views26Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Open Clinical Trial of Fluoxetine in the Treatment of Premature Ejaculation (1996)

There have been an increased number of recent reports on orgasm-related sexual dysfunction coincident with selective serotonin reuptake inhibitor (SSRI) treatment. In contrast, it has also been reported that SSRIs improve sexual dysfunction. Low doses of clomipramine and paroxetine, potent 5-hydroxytryptamine reuptake blockers, have been found to retard ejaculation time. We hypothesized that the SSRI fluoxetine might be effective in treating premature ejaculation. In an 8-week open-label clinical study, 11 male patients with premature ejaculation were treated with fluoxetine. After a washout period of 2 weeks, each patient was assigned to receive fluoxetine, 20 mg/day for 2 weeks, and then titrated to 60 mg/day, depending on the patient's tolerability and clinical response. A within-subjects comparison of pre- and posttreatment intravaginal ejaculation latency time revealed a significant improvement. Fluoxetine treatment produced significant improvements in self-visual analogue scale scores for sexual desire, anxiety for rapid ejaculation, and partner's satisfaction with ejaculation and overall sexual function. These data suggest that serotonergic antidepressants may be effective in treating rapid ejaculation in men and underline the need to carry out a double-blind, placebo-controlled trial to confirm these results.
Visually Sexing Loggerhead Shrike (<em>Lanius Ludovicianus</em>) Using Plumage Coloration and Pattern (2020)

The loggerhead shrike is a small sexually monomorphic passerine bird using grassland habitats across North America. Based on Breeding Bird Survey data, the species has undergone a drastic decline since the mid-1960s. The cause of decline is unknown, and research is actively underway to address this knowledge gap. These efforts are hindered by an inability to sex the species in hand, which to date was only possible using molecular markers. Here, we present a protocol to sex loggerhead shrikes by visually analyzing the coloration and pattern in the sixth primary feather. The application of the method will facilitate our ability to identify threats on a finer scale than has been possible to date and to address various ecological and evolutionary hypotheses. The methodology is simple and results reliable-we encourage including this method for research of both in situ and ex situ populations.
P078 Mucosal tissue short chain fatty acids contribute to prediction of pouchitis in restorative proctocolectomy (2019)

Restorative proctocolectomy is a surgical option in patients with ulcerative colitis who become refractory to medical therapy. Short chain fatty acids (SCFA) are organic fatty acids with 1–6 carbons which arise from bacterial metabolism from carbohydrates entering the colon. Various studies have implicated SCFA in both the development of IBD and flares of IBD. Furthermore, it has been shown that SCFA concentrations are significantly lower in faecal samples from patients with pouchitis when compared with healthy controls. Our study aimed to assess longitudinal changes in SCFA that occur in a pouch to determine whether they can predict or are associated with the development of pouchitis. To date no study has analysed short chain fatty acids in mucosal biopsy tissue from these patients. Patients who underwent restorative proctocolectomy at a single centre underwent pouchoscopy at the time of restoration of continuity and then every 6 months for a year. Biopsies from the pouch were retrieved from the pouch body. Pouchitis was defined using the pouch disease activity index. The development of pouchitis was assessed at months 6 and 12 months. Biopsies samples were snap frozen at time of biopsy and stored in −80°C. Samples were thawed and weighed. SCFA were measured using an Agilent 7000C Triple Quadrupole GC/MS-MS System. Simca was used for multivariate analysis and T-tests were used for univariate analysis. There were 56 biopsy samples. There were 22 patients (17 males); 16 UC and 6 FAP patients with longitudinal follow-up. The median age of the cohort was 40 years (range 20–60 years). Of the UC patients four developed pouchitis within 1 year. When comparing UC patients at the time of closure of ileostomy, there were there were significant decreases in caproic acid (4674 µM vs. 12217 µM; p < 0.01), valeric acid (1580 µM vs. 3695 µM; p = 0.01), isovolaric acid (721 µM vs. 2940 µM; p = 0.05), isobutyric acid 35072 µM vs. 76074 µM; p = 0.03) and lactic acid (1580 µM vs. 3732 µM p = 0.02) between those who developed pouchitis within a year and those who did not develop pouchitis at 1 year. There were no significant differences detected between UC patients and FAP patients at each time point analysis. The study has suggested that a decrease in SCFA found in the mucosal tissue at time of closure of ileostomy may predict onset of pouchitis within a year. This study is the first to demonstrate that SCFA can be analysed from biopsies. Future studies need to determine factors that may contribute to tissue SCFA levels which may help develop a potential therapeutic target to optimise and potentially reduce the incidence of pouchitis.
DNA complexes with block and graft copolymers of N-(2-hydroxypropyl)methacrylamide and 2-(trimethylammonio)ethyl methacrylate (1999)

Block and graft copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) with 2-(trimethylammonio)ethyl methacrylate (TMAEM) were synthesized for the preparation of polyelectrolyte complexes with calf thymus DNA intended for targeted delivery of genes in vivo. In this study, the effects of the poly(HPMA) content of copolymers on the parameters of the interpolyelectrolyte complexes is investigated. Static and dynamic light scattering methods were used as a main tool for characterization. The ability of the copolymers to condense DNA was studied by the ethidium bromide displacement method. The stability of the complexes against precipitation in 0.15 M NaCl and the resistance of the complexed DNA to the action of nucleases was also studied. It was found that the presence of poly(HPMA) in the copolymers has not significantly affected the ability of poly(TMAEM) parts of the copolymers to form complexes with DNA, but has an effect on molecular parameters and aggregation (precipitation) of the complexes. The size of the complexes increases with increasing poly(HPMA) content while their apparent molecular weight decreases. The complex stability against precipitation in 0.15 M NaCl strongly depends on the amount of poly(HPMA) in the copolymer structure. The presence of a sufficiently high content of poly(HPMA) is a prerequisite for achieving good stability. The structure of the complexes changes with increasing poly(HPMA) content from soft balls to the polymer coil. The density of the complexes decreases with increasing poly(HPMA) content independently of the copolymer structure. The DNA complexes of all copolymers showed very good nuclease stability.
Copper(I) Iodide-Catalyzed Coupling Reaction of Haloindoles with α-Amino Acids (2007)

Copper(I) iodide-catalyzed amination of haloindoles with amino acids using a combination of Cs 2 CO 3 in DMSO was explored.Amino acid derivatives with indole skeleton were smoothly afforded in moderate yields.
Machine Learning for Flavor Development (2019)

Currently, most flavor development is performed by chemists who experimentally iterate many times to find flavors that best fit specified requirements. In this study, three potential algorithms for automating and accelerating this process are examined and implemented, and the results are analyzed. The apriori algorithm, which generates probabilistic association rules, fails because it only predicts the coexistence of high-frequency features. The generative adversarial network (GAN) fails because the generator only exploits a small part of the solution space. However, the variational autoencoder (VAE) successfully recovers purposely omitted features 95.6% of the time, making it the most promising algorithm.
Using multi-FPGA systems for ASIC prototyping (2009)

Multi-FPGA systems are a growing area of research. They offer the potential to deliver high performance solutions to general computing tasks, especially for the prototyping of digital logic. However, to realize this potential requires a flexible, powerful hardware substrate and a complete, high quality and high performance automatic mapping system. This paper discusses different aspects of multi-FPGA systems as well as various issues that must be taken into account when using multi-FPGA systems to prototype an ASIC or SoC design.
Free-viewpoint Video Communication Using Multi-view Video Coding (2004)

We propose a video communication method that lets the user freely change his/her viewing position and viewing direction. Free-viewpoint video is a next-generation visual application that has been extensively studied and discussed by the international MPEG standard body as 3DAV (three-dimensional audio and visual). For this application, we propose a multi-view video coding method and communication protocol. We also describe a free-viewpoint video viewer that generates a natural view from an arbitrary viewing position and viewing direction, using decoded multi-view video data and generated image data by the Ray-Space interpolation and extrapolation methods.
Calcifying Pseudoneoplasms of the Skull Base Presenting with Cranial Neuropathies: Case Report and Literature Review (2012)

Objectives We report our institutional experience with calcifying pseudoneoplasms of the skull base that presented with cranial neuropathies. These lesions are also known as fibro-osseous lesions, cerebral calculi, or brain stones. Results One patient presented with facial numbness and retro-orbital pain secondary to compression of the maxillary branch of the trigeminal nerve at the anterior portion of the infratemporal fossa. The other patient presented with occipital headaches and hypoglossal nerve palsy. This patient was found to have a calcified lesion in the posterior fossa, which eroded the left occipital condyle. Conclusion Calcifying pseudoneoplasms are benign, slow-growing masses that are apparently cured by gross total resection. Even with incomplete tumor resection, the prognosis is considered to be favorable. We advocate a minimally invasive surgical resection of such tumors involving the cranial nerves.
Electronic structure of Pb- and non-Pb-based phosphate scintillators (2006)

The electronic structures of Pb and non-Pb containing phosphates, specifically ${\mathrm{Pb}}_{3}{(\mathrm{P}{\mathrm{O}}_{4})}_{2}$, ${\mathrm{Pb}}_{2}{\mathrm{P}}_{2}{\mathrm{O}}_{7}$, $\mathrm{Sc}\mathrm{P}{\mathrm{O}}_{4}$, $\mathrm{Y}\mathrm{P}{\mathrm{O}}_{4}$, and $\mathrm{Lu}\mathrm{P}{\mathrm{O}}_{4}$, are compared using a combination of density functional calculations and optical measurements. We find that the characteristic difference between these two classes is that the band gaps in the Pb containing materials are significantly lower because of the presence of Pb $6p$ derived bands in the gap between the valence bands and the P-O antibonding states. This may be favorable from the point of view of energy transfer in scintillator applications of Pb-based phosphates. However, it also suggests that different activators than those used in other phosphate scintillators may be useful to increase the efficiency.
Extracellular proline aminopeptidase production by Streptomyces lavendulae ATCC14162 under solid-state fermentation (2013)

This study presents extracellular Proline aminopeptidase (PAP) production by Streptomyces lavendulae ATCC 14162 under solid state fermentation (SSF). After optimization of few significant parameters (particle size of selected substrate, inoculums size, initial moisture level and incubation time), maximum PAP production was found to be 83.07 IU/gds. This is the first report on extracellular PAP production using SSF by a Streptomyces culture.
Alterations in aortic endothelial cell morphology and cytoskeletal protein synthesis during cyclic tensional deformation. (1988)

Previous studies have shown that bovine aortic endothelial cells (ECs) in culture respond to repetitive tensional deformation with an increase in deoxyribonucleic acid synthesis and cell proliferation. This study was designed to determine whether cyclic tensional deformation of ECs in vitro induces different morphologic or protein synthetic responses. ECs from passages 6 through 9 were seeded in 35 mm2 well silicone rubber plates at 2 x 10(5) cells/well and allowed to attach for 24 hours. The experimental group was placed in a vacuum-operated stress-providing device that exerted an elongation of 24% at maximum downward deflection of the culture plate bottom and was subjected to repetitive cycles of 10 seconds of 24% maximum elongation and 10 seconds of relaxation for 5 days. The control group was subjected to similar incubation conditions but without stretch. 35S-methionine (500 muCi/well) was added to the plates 24 hours before harvesting, and two-dimensional gels of the harvested lysates (isoelectric focusing with pH 3 to 10 ampholytes followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis on 12.5% gels) were performed and the labeled proteins visualized by autoradiography. The data indicate that there is a differential synthesis of proteins, with synthesis of some proteins decreased or ablated whereas other proteins were increased in response to cyclic mechanical tension. The actin filament organization was evaluated after staining with rhodamine phalloidin, a fluorescent F-actin probe. The ECs subjected to tension had a more polygonal shape and demonstrated pseudopods and actin stress fibers, whereas ECs cultured under static conditions were more rounded and did not express actin stress cables.(ABSTRACT TRUNCATED AT 250 WORDS)
Schistosoma mansoni coactivator associated arginine methyltransferase 1 (SmCARM1) effect on parasite reproduction (2023)

This work brings the first functional characterization of SmCARM1 shedding light on its roles in <i>S. mansoni</i> biology and its potential as a drug target. Additional studies are necessary to investigate whether the reported effects of Sm<i>carm</i>1 knockdown are a consequence of the SmCARM1-mediated methylation of histone tails involved in DNA packaging or other non-histone proteins.
Gain-bandwidth product optimization of heterostructure avalanche photodiodes (2005)

A generalized history-dependent recurrence theory for the time-response analysis is derived for avalanche photodiodes with multilayer, heterojunction multiplication regions. The heterojunction multiplication region considered consists of two layers: a high-bandgap Al/sub 0.6/Ga/sub 0.4/As energy-buildup layer, which serves to heat up the primary electrons, and a GaAs layer, which serves as the primary avalanching layer. The model is used to optimize the gain-bandwidth product (GBP) by appropriate selection of the width of the energy-buildup layer for a given width of the avalanching layer. The enhanced GBP is a direct consequence of the heating of primary electrons in the energy-buildup layer, which results in a reduced first dead space for the carriers that are injected into the avalanche-active GaAs layer. This effect is akin to the initial-energy effect previously shown to enhance the excess-noise factor characteristics in thin avalanche photodiodes (APDs). Calculations show that the GBP optimization is insensitive to the operational gain and the optimized APD also minimizes the excess-noise factor.
Selecting Mid-infrared Filters for a Machine Learning Chemical Classifier by Genetic Optimization (2022)

We use a genetic algorithm to optimize six mid-infrared filters for a machine learning classifier that identifies chemicals from their infrared transmission. The model is tested by classifying 15 chemical classes via simulations with noise.
Clusterin wirkt protektiv in der Pankreatitis durch seine anti-apoptotischen und anti-entzündlichen Eigenschaften (2005)

Einleitung: Clusterin, ein Glykoprotein, das durch Zellstress induziert wird und an der Apoptoseregulation beteiligt ist, wird in der Akutphase einer Pankreatitis überexprimiert. Ziel der Studie war die Untersuchung der Funktion von Clusterin im exokrinen Pankreas.
PVP-Coated Iron Nanocrystals:  Anhydrous Synthesis, Characterization, and Electrocatalysis for Two Species (2006)

We report the synthesis of Fe nanocrystals (approximately 9 nm) in an anhydrous media, formamide, using poly(N-vinyl-2-pyrrolidone) (PVP) as a protecting agent. The morphology, structure, and composition of the PVP-coated Fe nanocrystals are studied by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and FT-Raman spectroscopy. The surface properties of the PVP-coated Fe nanocrystals are studied by electrochemistry and micro-surface-enhanced Raman scattering (mSERS) using pyridine as a probing molecule. The PVP-coated Fe nanocrystals, when immobilized on an electrode substrate, display very good electrocatalytic activities in the selective reduction of H2O2 in the presence of oxygen and in the oxidation of NO.