gebhart/patrepeval huggingface dataset:
Manufacturing and metrology tooling for the Solar-A Soft X-Ray Telescope (1990)

The Solar-A Soft X-Ray telescope will be launched aboard the Japanese Solar-A Satellite in 1991, to study the sun during the next period of sunspot activity. The mechanical and optical design of this monolithic, near 2 arc-sec image quality Nariai Telescope was developed previously as explained in reference 1 and depicted in Figure 2.0. Successful achievement of the aggressive performance goals for this design required precision manufacturing and assembly, and accurate metrology to verify results. In fact, more than three-fourths of the error budget was allocated to manufacturing and meirology errors because of the recognized difficulty in producing and measuring the precision grazing-incident optical surfaces. To obtain the anufacturing precision and metrology accuracy desired, specialized tooling had to be designed to support and mount the optical substrate during the fabrication, surface metrology, alignment and assembly processes. The design considerations, the substantiating structural analyses performed and the resulting successful application of this specialized tooling are reported here in to show the difficulties often encountered in developing "support" equipment to achieve desired results in the final product.
Lowpass Filter Design Based on Microstrip Meander Line with HDGS (2014)

A microstrip meander line with a single H-shaped Defected Ground Structure (HDGS) is employed to design a novel compact lowpass filter with sharp roll off and wide stop band. Two parametric studies were conducted to analyze the sensitivity of the HDGS position and the size effects on the filter response. The design is fabricated to have a 6 GHz cutoff frequency using Rogers TMM 10i substrate, with an area of 7.6 x 6 mm2 . The measured results are in a good agreement with simulation prediction.
ChemInform Abstract: Applications of Aza‐ and Phosphaferrocenes and Related Compounds in Asymmetric Catalysis (2011)

Abstract Review: 95 refs.
Characterization and polyanion-binding properties of purified recombinant prion protein (1999)

Certain polysulphated polyanions have been shown to have prophylactic effects on the progression of transmissible spongiform encephalopathy disease, presumably because they bind to prion protein (PrP). Until now, the difficulty of obtaining large quantities of native PrP has precluded detailed studies of these interactions. We have over-expressed murine recombinant PrP (recPrP), lacking its glycophosphoinositol membrane anchor, in modified mammalian cells. Milligram quantities of secreted, soluble and partially glycosylated protein were purified under non-denaturing conditions and the identities of mature-length aglycosyl recPrP and two cleavage fragments were determined by electrospray MS. Binding was assessed by surface plasmon resonance techniques using both direct and competitive ligand-binding approaches. recPrP binding to immobilized polyanions was enhanced by divalent metal ions. Polyanion binding was strong and showed complex association and dissociation kinetics that were consistent with ligand-directed recPrP aggregation. The differences in the binding strengths of recPrP to pentosan polysulphate and to other sulphated polyanions were found to parallel their in vivo anti-scrapie and in vitro anti-scrapie-specific PrP formation potencies. When recPrP was immobilized by capture on metal-ion chelates it was found, contrary to expectation, that the addition of polyanions promoted the dissociation of the protein.
Anti-Thomsen-Friedenreich-Ag anti-TF-Ag potential for cancer therapy (2012)

Thomsen-Friedenreich antigen (TF-Ag) is the disaccharide (Gal beta1-3 GalNAc alpha), which is also known as the core 1 structure. The presence of this disaccharide on the surface of approximately 90 percent of carcinomas is due to altered glycosylation in these tumors. TF-Ag plays a role in the adhesive properties of tumor cells involved in metastasis. Treatment of mice with JAA-F11, a monoclonal antibody to TF-Ag alpha inhibited lung metastasis and improved prognosis in a mouse breast cancer model. The presence of naturally occurring antibodies to TF-Ag in cancer patients is related to improved prognosis. The pancarcinoma expression of TF-Ag, combined with the evidence of a mechanistic role for TF-Ag in cancer spread, show that this target would have clinical utility. The presence of naturally occurring antibody to TF-Ag indicates that increasing the anti-TF-Ag antibody would be safe for the cancer patient and indicates that tolerance would not have to be broken to create this immune response. Finally, the prognostic improvements seen clinically and in animal models indicate that this is an important vaccine target.
Processor Security: Detecting Microarchitectural Attacks via Count-Min Sketches (2022)

The continuous quest for performance pushed processors to incorporate elements such as multiple cores, caches, acceleration units, or speculative execution that make systems very complex. On the other hand, these features often expose unexpected vulnerabilities that pose new challenges. For example, the timing differences introduced by caches or speculative execution can be exploited to leak information or detect activity patterns. Protecting embedded systems from existing attacks is extremely challenging, and it is made even harder by the continuous rise of new microarchitectural attacks (e.g., the Spectre and Orchestration attacks). In this article, we present a new approach based on count-min sketches for detecting microarchitectural attacks in the microprocessors featured by embedded systems. The idea is to add to the system a security checking module (without modifying the microprocessor under protection) in charge of observing the fetched instructions and identifying and signaling possible suspicious activities without interfering with the nominal activity of the system. The proposed approach can be programmed at design time (and reprogrammed after deployment) in order to always keep updated the list of the attacks that the checker is able to identify. We integrated the proposed approach in a large RISC-V core, and we proved its effectiveness in detecting several versions of the Spectre, Orchestration, Rowhammer, and Flush + Reload attacks. In its best configuration, the proposed approach has been able to detect 100% of the attacks, with no false alarms and introducing about 10% area overhead, about 4% power increase, and without working frequency reduction.
Chiral Transmission between Amino Acids: Chirally Selective Amino Acid Substitution in the Serine Octamer as a Possible Step in Homochirogenesis (2002)

Chiral exchange: Substitution of cysteine for serine in the homochiral serine octamer (see calculated structure) occurs in a chirally dependent fashion and may represent an example of transfer of chirality between primitive biological molecules. The findings are supported by HF/6-31G calculations.
Mapping harmful algal blooms in the Laurentian Great Lakes: an analysis of HAB occurrences since 2002 (2014)

Harmful Algal Blooms (HABs) occurrence in the Great Lakes is becoming increasingly problematic as they occur more frequently, in larger areas, and with rising severity. Remote sensing that utilizes both satellite and airborne imagery has been effectively used to map and monitor HAB events in the Great Lakes in order to help decision makers understand the extent of the problem. The mapping algorithm uses MODIS satellite imagery to identify areas of high chlorophyll concentration as well as areas of floating scum. The mapping algorithm was used to process cloud free imagery covering Green Bay, WI, Saginaw Bay, MI and the Western Basin of Lake Erie, MI/OH from 2002 through the fall of 2013. The resultant time series for each AOC was analyzed to show trends in HAB onset/offset dates, trends in average total HAB area for each year as well as average floating extent and average high chlorophyll area extent. The time series study was also able to highlight locations within each study area that are consistently plagued by long-term HAB inundation. Together, these spatial and temporal measures were used to show how harmful algal blooms have changed over time.
Evaluation of copper-dependent proteasome-inhibitory and apoptosis-inducing activities of novel pyrrolidine dithiocarbamate analogues (2007)

Apoptosis has a central role in the pathogenesis of many human diseases, one of which is cancer. One of the most important strategies to regulate apoptosis is via the ubiquitin-proteasome pathway. It has been shown that inhibition of proteasomal chymotrypsin-like activity is a strong apoptosis-inducing stimulus and that actively proliferating cancer cells are more sensitive to proteasome inhibitors than normal or untransformed cells. Dithioscarbamates are a class of metal-chelating compounds with various applications in medicine. We reported previously that certain members of dithiocarbamates, such as pyrrolidine dithiocarbamate (PDTC), diethyldithiocarbamate and disulfiram, are able to bind with tumor cellular copper, forming an active complex with proteasome-inhibitory, apoptosis-inducing and anti-cancer activities. In the current study, we synthesized eight PDTC analogues with substitutions made to the pyrrolidine ring and studied their structure-activity relationships. We found that substitution of the pyrrolidine ring with piperidine had almost no effect on their proteasome-inhibitory and anti-proliferative potencies in human breast cancer cells. However, after the pyrrolidine ring was substituted with morpholine, the activity of the mixtures slightly decreased but was completely lost when piperazine with the attached ethyl group was used for the substitution. This structure-activity relationship was confirmed by the results generated with the corresponding copper complexes. Our data further support the novel concept of using accumulated copper in human cancer cells as a selective approach for chemotherapy.
ARToolKit on the PocketPC platform (2004)

In this paper, we describe the port of ARToolKit onto the PocketPC platform including optimizations that led to a three-fold speedup over the native cross-compiled version. The ported ARToolKit module was successfully used in the Handheld AR project.
Supplementary 4 from A Novel Anti-CD22 Anthracycline-Based Antibody–Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs (2023)

&lt;p&gt;Supplementary 4. P-gp overexpressing BJAB.Luc cell line showed the similar resistance to anti-CD22-vc-MMAE&lt;/p&gt;
Menstrual Cycle Phase Not Exercise Intensity Affects ACL Laxity in Women (2018)

Please download pdf version here.
CDFG-Petri net temporal partitioning for switching context applications (2002)

The reconfigurable computing has presented a promising progress. The development of platforms that match the reconfigurable hardware with programmable elements, such as DSPs or microprocessors promise great applicability in diverse areas in the future. In this article we describe a co-design methodology for single-context and virtual hardware applications based on Petri net for PISH design environment. A platform description is presented as well as the reconfiguration methodology. A temporal partitioning is described exploring different solutions for different applications with time and communication constraint.
Technical Note: The Mechanism of Corrosion Inhibition by Phosphate-Based Cooling System Corrosion Inhibitors (1986)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation G. Saha, N. Kurmaih; Technical Note: The Mechanism of Corrosion Inhibition by Phosphate-Based Cooling System Corrosion Inhibitors. CORROSION 1 April 1986; 42 (4): 233–235. doi: https://doi.org/10.5006/1.3586001 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search
Remark on algorithm 659 (2003)

An algorithm to generate Sobol' sequences to approximate integrals in up to 40 dimensions has been previously given by Bratley and Fox in Algorithm 659. Here, we provide more primitive polynomials and "direction numbers" so as to allow the generation of Sobol' sequences to approximate integrals in up to 1111 dimensions. The direction numbers given generate Sobol' sequences that satisfy Sobol's so-called Property A.
MicroRNA Expression in Clear Cell Renal Cell Carcinoma Cell Lines and Tumor Biopsies: Potential Therapeutic Targets (2022)

This study was carried out to quantitate the expression levels of microRNA-17, -19a, -34a, -155, and -210 (miRs) expressed in nine clear cell renal cell carcinoma (ccRCC) and one chromophobe renal cell carcinoma cell line with and without sarcomatoid differentiation, and in six primary kidney tumors with matching normal kidney tissues. The data in the five non-sarcomatoid ccRCC cell lines-RC2, CAKI-1, 786-0, RCC4, and RCC4/VHL-and in the four ccRCC with sarcomatoid differentiation-RCJ41T1, RCJ41T2, RCJ41M, and UOK-127-indicated that miR-17 and -19a were expressed at lower levels relative to miR-34a, -155, and -210. Compared with RPTEC normal epithelial cells, miR-34a, miR-155, and miR-210 were expressed at higher levels, independent of the sarcomatoid differentiation status and hypoxia-inducible factors 1α and 2α (HIFs) isoform expression. In the one chromophobe renal cell carcinoma cell line, namely, UOK-276 with sarcomatoid differentiation, and expressing tumor suppressor gene <i>TP53</i>, miR-34a, which is a tumor suppressor gene, was expressed at higher levels than miR-210, -155, -17, and -19a. The pilot results generated in six tumor biopsies with matching normal kidney tissues indicated that while the expression of miR-17 and -19a were similar to the normal tissue expression profile, miR-210, -155, -and 34a were expressed at a higher level. To confirm that differences in the expression levels of the five miRs in the six tumor biopsies were statistically significant, the acquisition of a larger sample size is required. Data previously generated in ccRCC cell lines demonstrating that miR-210, miR-155, and HIFs are druggable targets using a defined dose and schedule of selenium-containing molecules support the concept that simultaneous and concurrent downregulation of miR-210, miR-155, and HIFs, which regulate target genes associated with increased tumor angiogenesis and drug resistance, may offer the potential for the development of a novel mechanism-based strategy for the treatment of patients with advanced ccRCC.
Two CCAAT‐box‐binding transcription factors redundantly regulate early steps of the legume‐rhizobia endosymbiosis (2014)

During endosymbiotic interactions between legume plants and nitrogen-fixing rhizobia, successful root infection by bacteria and nodule organogenesis requires the perception and transduction of bacterial lipo-chitooligosaccharidic signal called Nod factor (NF). NF perception in legume roots leads to the activation of an early signaling pathway and of a set of symbiotic genes which is controlled by specific early transcription factors (TFs) including CYCLOPS/IPD3, NSP1, NSP2, ERN1 and NIN. In this study, we bring convincing evidence that the Medicago truncatula CCAAT-box-binding NF-YA1 TF, previously associated with later stages of rhizobial infection and nodule meristem formation is, together with its closest homolog NF-YA2, also an essential positive regulator of the NF-signaling pathway. Here we show that NF-YA1 and NF-YA2 are both expressed in epidermal cells responding to NFs and their knock-down by reverse genetic approaches severely affects the NF-induced expression of symbiotic genes and rhizobial infection. Further over-expression, transactivation and ChIP-PCR approaches indicate that NF-YA1 and NF-YA2 function, at least in part, via the direct activation of ERN1. We thus propose a model in which NF-YA1 and NF-YA2 appear as early symbiotic regulators acting downstream of DMI3 and NIN and possibly within the same regulatory complexes as NSP1/2 to directly activate the expression of ERN1.
Collective Generation of Natural Image Descriptions (2012)

We present a holistic data-driven approach to image description generation, exploiting the vast amount of (noisy) parallel image data and associated natural language descriptions available on the web. More specifically, given a query image, we retrieve existing human-composed phrases used to describe visually similar images, then selectively combine those phrases to generate a novel description for the query image. We cast the generation process as constraint optimization problems, collectively incorporating multiple interconnected aspects of language composition for content planning, surface realization and discourse structure. Evaluation by human annotators indicates that our final system generates more semantically correct and linguistically appealing descriptions than two nontrivial baselines. 1
Fabrication of Different Protective Coatings and Studying their Mechanical Properties and Corrosion Behavior in Sodium Chloride Solutions (2015)

Five formulations of protective coatings were fabricated by treating bisphenol based epoxy resin A (BBERA) with different stoichiometry variations of polyaminoamine 115-Cray valley (PAA-115) as a hardener at ambient temperature. The fabricated epoxy coatings were first applied on glass plates for studying their mechanical properties. Other portions of the coatings were applied on steel substrates for reporting the corrosion behavior in an aerated 0.6 M NaCl solution. The chemical composition of the fabricated formulations was characterized using Fourier-transform infrared spectroscopy (FT-IR). A differential scanning calorimetry was used to report the thermal degradation of the fabricated coatings. The mechanical properties for the different coatings were evaluated using various techniques such as cross hatch tester, pendulum hardness, mandrel bend, and scratch tester measurements. The corrosion behavior for all coated steels after 60 min and 7.0 days immersion in 0.6 M NaCl solutions was performed using electrochemical impedance spectroscopy (EIS) investigations. It has been found that the five fabricated coatings provide high thermal stability, excellent mechanical properties and good corrosion behavior and their corrosion resistance decreased with increasing the exposure time from 60 min to 7.0 days before measurement.
Understanding the Fundamentals of Microporosity Upgrading in Zeolites: Increasing Diffusion and Catalytic Performances (2021)

Hierarchical zeolites are regarded as promising catalysts due to their well-developed porosity, increased accessible surface area, and minimal diffusion constraints. Thus far, the focus has been on the creation of mesopores in zeolites, however, little is known about a microporosity upgrading and its effect on the diffusion and catalytic performance. Here the authors show that the "birth" of mesopore formation in faujasite (FAU) type zeolite starts by removing framework T atoms from the sodalite (SOD) cages followed by propagation throughout the crystals. This is evidenced by following the diffusion of xenon (Xe) in the mesoporous FAU zeolite prepared by unbiased leaching with NH<sub>4</sub> F in comparison to the pristine FAU zeolite. A new diffusion pathway for the Xe in the mesoporous zeolite is proposed. Xenon first penetrates through the opened SOD cages and then diffuses to supercages of the mesoporous zeolite. Density functional theory (DFT) calculations indicate that Xe diffusion between SOD cage and supercage occurs only in hierarchical FAU structure with defect-contained six-member-ring separating these two types of cages. The catalytic performance of the mesoporous FAU zeolite further indicates that the upgraded microporosity facilitates the intracrystalline molecular traffic and increases the catalytic performance.
3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims. (1988)

An excess of the tryptophan metabolite quinolinic acid in the brain has been hypothetically related to the pathogenesis of Huntington disease. Quinolinate's immediate biosynthetic enzyme, 3-hydroxyanthranilate oxygenase (EC 1.13.11.6), has now been detected in human brain tissue. The activity of 3-hydroxyanthranilate oxygenase is increased in Huntington disease brains as compared to control brains. The increment is particularly pronounced in the striatum, which is known to exhibit the most prominent nerve-cell loss in Huntington disease. Thus, the Huntington disease brain has a disproportionately high capability to produce the endogenous "excitotoxin" quinolinic acid. This finding may be of relevance for clinical, neuropathologic, and biochemical features associated with Huntington disease.
Polypeptides having endoglucanase activity and polynucleotides encoding same (2023)

The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
Risk Factors Associated With Ampicillin-Resistant Infection in Newborns in the Era of Group B Streptococcal Prophylaxis (2004)

No increase in early-onset infections with gram-negative or ampicillin-resistant pathogens was detected. Ampicillin-resistant early-onset infection was associated with intrapartum antibiotics given for 24 hours or longer prior to delivery and with clinical chorioamnionitis. Ampicillin sodium and gentamicin sulfate remain appropriate initial antibiotic therapies for early-onset infection in newborns weighing at least 1500 g and without these risk factors.
MANAS: Multi-Scale and Multi-Level Neural Architecture Search for Low-Dose CT Denoising (2021)

Lowering the radiation dose in computed tomography (CT) can greatly reduce the potential risk to public health. However, the reconstructed images from the dose-reduced CT or low-dose CT (LDCT) suffer from severe noise, compromising the subsequent diagnosis and analysis. Recently, convolutional neural networks have achieved promising results in removing noise from LDCT images; the network architectures used are either handcrafted or built on top of conventional networks such as ResNet and U-Net. Recent advance on neural network architecture search (NAS) has proved that the network architecture has a dramatic effect on the model performance, which indicates that current network architectures for LDCT may be sub-optimal. Therefore, in this paper, we make the first attempt to apply NAS to LDCT and propose a multi-scale and multi-level NAS for LDCT denoising, termed MANAS. On the one hand, the proposed MANAS fuses features extracted by different scale cells to capture multi-scale image structural details. On the other hand, the proposed MANAS can search a hybrid cell- and network-level structure for better performance. Extensively experimental results on three different dose levels demonstrate that the proposed MANAS can achieve better performance in terms of preserving image structural details than several state-of-the-art methods. In addition, we also validate the effectiveness of the multi-scale and multi-level architecture for LDCT denoising.
Capecitabine (XEL) and Mitomycin-C (MMC) used concurrently with accelerated concomitant boost radiation therapy (CB-RT) in head and neck cancer (SCCHN): Preliminary results of a phase I clinical trial (2005)

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