gebhart/patrepeval huggingface dataset:
Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome (2016)

Cerebrospinal fluid (CSF) is virtually the only one accessible source of proteins derived from the central nervous system (CNS) of living humans and possibly reflects the pathophysiology of a variety of neuropsychiatric diseases. However, little is known regarding the genetic basis of variation in protein levels of human CSF. We examined CSF levels of 1,126 proteins in 133 subjects and performed a genome-wide association analysis of 514,227 single nucleotide polymorphisms (SNPs) to detect protein quantitative trait loci (pQTLs). To be conservative, Spearman's correlation was used to identify an association between genotypes of SNPs and protein levels. A total of 421 cis and 25 trans SNP-protein pairs were significantly correlated at a false discovery rate (FDR) of less than 0.01 (nominal P < 7.66 × 10-9). Cis-only analysis revealed additional 580 SNP-protein pairs with FDR < 0.01 (nominal P < 2.13 × 10-5). pQTL SNPs were more likely, compared to non-pQTL SNPs, to be a disease/trait-associated variants identified by previous genome-wide association studies. The present findings suggest that genetic variations play an important role in the regulation of protein expression in the CNS. The obtained database may serve as a valuable resource to understand the genetic bases for CNS protein expression pattern in humans.
Intervention versus Aggressive Medical Therapy for Cognition in Severe Asymptomatic Carotid Stenosis (2016)

Both aggressive medical therapy alone and combined carotid revascularization in ≧70% asymptomatic carotid stenosis similarly preserved cognition during 3-month follow-up, though the latter had the potential for dizziness alleviation and cognitive and connectivity enhancement.
Development of low-loss optical coatings for 157-nm lithography (2002)

In the F<SUB>2</SUB> laser lithography, it is essential to reduce the loss of the optical coatings deposited on calcium fluoride lenses. In order to make low loss optical coatings, we have developed measurement apparatus, evaluated the coatings with various analyses, and found a correlation with the optical constants. In this paper we describe the optical loss measurement apparatus and the evaluation results analyzed for either single layer coatings or multi-layer anti-reflection coatings.
Water Solubility Measurements of the CO2-Rich Liquid Phase in Equilibrium with Gas Hydrates Using an Indirect Method (2011)

The solubility of water in the CO2-rich phase was measured in the presence of hydrate using an indirect method at the temperatures ranging from (274 to 294) K and pressures of (6.1 and 10.1) MPa. The experimental data set of Song and Kobayashi (SPE Form. Eval.1987, 2, 500−508) was previously reported for this system, and a large pressure dependence was observed at the pressures of (6.21 and 10.34) MPa. The present solubility data were compared with published experimental data at the hydrate-free region. A weak pressure dependence was observed compared with the data of Song and Kobayashi in the present measurements.
Amidosilylcyclopentadienyl Monoalkyl Zirconium Compounds: Evidence of a N-Assisted 1,3-Proton Shift Olefin Isomerization Mechanism (2009)

New η5-cyclopentadienyl-η1-amido monoalkyl zirconium compounds of the type [ZrR(η5-C5H4SiMe2-η1-NtBu)(η5-C5H4R′)] (R = Me, Bn; R′ = H, SiMe3, SiMe2CH2CH═CH2) have been synthesized and fully characterized. Allyldimethylsilylcyclopentadienyl derivatives [ZrR(η5-C5H4SiMe2-η1-NtBu)(η5-C5H4SiMe2CH2CH═CH2)] isomerize the allyl fragment bound to the cyclopentadienyl ring to give the corresponding [ZrR(η5-C5H4SiMe2-η1-NtBu)(η5-C5H4SiMe2CH═CHCH3)] compounds (R = Me, Bn). Experimental as well as DFT computational studies support an isomerization mechanism based on a N-assisted 1,3-proton shift.
Multistage wastewater treatment using separated storage driven denitrification and nitrification biofilms (2006)

The feasibility of combining a previously reported storage driven denitrification biofilm, where 80% of influent acetate can be converted to poly-beta-hydroxybutyrate (PHB), with a suitable nitrification reactor, either submerged or trickling filter design, to achieve complete biological nitrogen removal was tested. The reactor system showed the potential of complete biological nitrogen removal of waste streams with a C/N ratio as low as 3.93 kg COD/kg N-NH3 at an overall nitrogen removal rate of 1.1 mmole NH3/L/h. While the efficiency and the rates of nitrogen removal were higher than what is observed in traditional or simultaneous nitrification and denitrification (SND) systems, there were two problems that require further development: (a) the incomplete draining of the reactor caused ammonia retention and release in the effluent, limiting the overall N-removal and (b) pH drifts in the nitrification step slowed down the rate of nitrification if not corrected by appropriate pH adjustment or buffering.
Towards automatic large-scale curation of genomic variation: improving coverage based on supplementary material (2013)

There are ongoing large-scale efforts to catalog genomic variation related to disease in structured databases. Much of the relevant information is available only from unstructured sources, includ-ing the scientific literature. The abil-ity of text mining tools to recover the mutations catalogued in the COSMIC and InSiGHT databases based on the article text has been demonstrated to be far less than what would be ex-pected based on the excellent perfor-mance on intrinsic evaluation of muta-tion extraction tools. We explore the impact of processing tables and supple-mentary material associated to relevant literature, and find that the coverage of variants improves dramatically, from 2 % to over 50%. This result highlights the importance of processing all of the data associated with a publication. 1
Performance evaluation of switched reluctance motors with segmental rotors (2003)

This paper examines the performance of switched reluctance machines which employ a segmental rotor construction in preference to the usual toothed structure. Two 3 phase designs are considered, one in which the windings span a number of teeth and one in which they spin a single tooth. Two demonstrators have been built - one for each design type, and their performance is compared with both conventional SRMs and rare earth permanent magnet machines. Both static parameter and running test results are presented. It is shown how these machines can operate from a standard SRM converter: there is discussion of general operating experience, ranging from measurement of mean torque, voltage and current controlled operation to general thermal performance.
Protocol for Field Tests of Ultrasonic Devices for Rodent Management (1989)

Testing ultrasonic devices for rodent repellency in closed environments results in contradictory responses. Without alternative environments, such efficacy tests cannot approximate actual conditions, and can result in erroneous conclusions. Conducting observations in actual rodent-infested environments provides the best circumstances in which to measure the efficacy of high-frequency sound as a rodent management tool. Ideally, the installation of ultrasonic devices should be the only environmental variable. Rodent activity, measured with tracking patches, food consumption, or motion monitors before and after activation of units, is correlated with sound pressure patterns in the environment. Both frequency and sound pressure are important parameters. Preferably, two on/off cycles should be used.
A Brassica rapa Linkage Map of EST-based SNP Markers for Identification of Candidate Genes Controlling Flowering Time and Leaf Morphological Traits (2009)

For identification of genes responsible for varietal differences in flowering time and leaf morphological traits, we constructed a linkage map of Brassica rapa DNA markers including 170 EST-based markers, 12 SSR markers, and 59 BAC sequence-based markers, of which 151 are single nucleotide polymorphism (SNP) markers. By BLASTN, 223 markers were shown to have homologous regions in Arabidopsis thaliana, and these homologous loci covered nearly the whole genome of A. thaliana. Synteny analysis between B. rapa and A. thaliana revealed 33 large syntenic regions. Three quantitative trait loci (QTLs) for flowering time were detected. BrFLC1 and BrFLC2 were linked to the QTLs for bolting time, budding time, and flowering time. Three SNPs in the promoter, which may be the cause of low expression of BrFLC2 in the early-flowering parental line, were identified. For leaf lobe depth and leaf hairiness, one major QTL corresponding to a syntenic region containing GIBBERELLIN 20 OXIDASE 3 and one major QTL containing BrGL1, respectively, were detected. Analysis of nucleotide sequences and expression of these genes suggested possible involvement of these genes in leaf morphological traits.
Emerging viral respiratory infections (2005)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Emerging nanoelectronics: multi-functional nanowires (2005)

This talk aims to demonstrate that a silicon-on-insulator (SOI) nanowire technological platform could be a realistic approach to address the development of various types of multifunctional devices. Particularly, SOI nanowires could be a unique technological platform to co-fabricate: (i) nano-scaled solid-state MOS devices (such as the multi-gate MOSFETs); (ii) single-electron transistors and single electron memories; (iii) solid-state optoelectronic nano-scaled devices (modulators, optical switches, filters or even optical, interconnects for on-chip clock distribution...); and (iv) MEMS nano-resonators for full integrated RF IC functions. All these various categories of devices can take advantage of SOI intrinsic properties (technological toolset similar to silicon, natural lateral and vertical isolation, specific electrical, mechanical and optical properties) together with their aggressive scalability. Moreover, such, a technological platform could be hybridized with other nanotechnologies like molecular devices and carbon nanotubes. Some key examples, based on ongoing research projects at the Swiss Federal Institute of Technology Lausanne and world wide state-of-the-art was presented.
Energy Management Strategy based on Dynamic Programming Considering Engine Dynamic Operating Conditions Optimization (2020)

It is known that the hybrid vehicle energy management strategy based on dynamic programming (DP) can be used as a reference for other strategies. However, usually only fuel consumption of hybrid vehicles is focused on and dynamic conditions of engines are ignored. This research considers a plug-in hybrid electric vehicle as an object, a mathematical model of the vehicle and its energy management strategy based on dynamic programming are developed. The cost function of dynamic programming proposed in this paper not only pays attention to the fuel consumption of the vehicle, but also optimizes the engine start-stop state change and engine speed and torque fluctuation, thus ensuring the engine to work efficiently and have the potential of improving the emission performance. At the same time, entropy-weight method is introduced to determine the weight coefficients of the cost function, so that the determination process is separated from the subjective judgment and is closely linked with objective driving conditions. In addition, aiming at further improvement of DP optimization result when a lager discretization interval is selected for better real-time performance, a method for power deviation compensation is proposed. The simulation results show that the DP-based energy management strategy considering the optimization of engine dynamic operating conditions has a small increase in fuel consumption compared with the traditional DP-based strategy, but it can significantly reduce the dynamic operating conditions of the engine and reduce the fluctuation of engine speed and torque and the frequency of engine start-stop.
Semiconductor Raman Laser with Pump Light Wavelength in the 800 nm Region (1993)

Semiconductor Raman lasers with cores and cladding layers are operated with the pump wavelengths of 840 and 895 nm. In contrast to previous results for the pump wavelength of 1.064 μm, it is observed that the lasing characteristics for 840 and 895 nm excitation are affected by the instantaneous temperature rise due to the excess absorption, which strongly depends on the stripe width. Two photon absorption and absorption via deep levels produced at the side interfaces are discussed, and the latter is suggested as the origin of the excess absorption.
Molecular Library Obtained by Allene Insertion into the Pd−C Bond of Cyclopalladated Complexes: Biological and Pharmacological Evaluation (2004)

Abstract A minilibrary of cationic N‐heterocycles has been prepared and evaluated. The potential for the preparation was a result of the high versatility of palladium‐mediated chemistry. The synthesis of the novel molecules was based on intramolecular quaternization of tertiary amine attached allylpalladium complexes. The steric and electronic factors of the reaction are discussed. The structures of the synthesized molecules made them candidates for precise biological and pharmacological evaluations. Of the various N‐heterocyclic compounds, 2,2‐dimethyl‐3‐methylenenaphtho[ def ]quinolizinium showed antibacterial activity at micromolar concentrations. This compound also proved to be a nanomolar competitive antagonist for the channel site of the nicotinic acetylcholine receptor. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2004)
Reduction in cardiovascular disease events in patients with type 2 diabetes mellitus treated with a sodium–glucose cotransporter 2 inhibitor versus a dipeptidyl peptidase‐4 inhibitor: A real‐world retrospective administrative database analysis in Japan (2022)

In this real-world study, SGLT2i versus DPP4i was associated with a significant reduction in hHF, ACD and hHF or ACD events in patients with type 2 diabetes mellitus without a CVD history.
Culture of Human Cervical Epithelial Cells (2002)

The chapter starts with an anatomical and histological description of the uterine cervix, and an historical review of attempts at culture. Reagent preparation and protocols are provided for the culture of endo- and ectocervical keratinocytes on 3T3 feeder layers following trypsin disaggregation of mechanically separated epithelium. The preparation of the feeder layer is described and instructions given for subculture with feeder layers. A separate protocol is given for culture with serum-free KGM (MCDB 153). Culture cervical intraepithelial neoplasms (CIN) and carcinoma is described using a primary explantation without trypsinization. Characterization of cervical epithelia cell cultures has been achieved using cytokeratin and involucrin expression. Conditions for maximal expression of differentiation are provided using collagen rafts. Protocols for immortalization with BPV are also described.
Inside Back Cover: Hollow Spheres of Iron Carbide Nanoparticles Encased in Graphitic Layers as Oxygen Reduction Catalysts (Angew. Chem. Int. Ed. 14/2014) (2014)

Iron carbide nanoparticles encased in thin graphitic layers are active towards oxygen reduction. In their Communication on page 3675 ff., W. Xing, Q. F. Li, and co-workers report that hollow spheres composed of these nanoparticles without surface nitrogen or metallic functionalities show high activity and stability in both acidic and alkaline media. The catalysts are synthesized in a one-step process.
Standing Wave High Energy Linear Accelerator Structures (1968)

The design and operation of resonant linear accelerator tanks suitable for use in high energy proton and electron linacs is described. It is shown that construction of these tanks to operate in the π/2 mode yields systems with extraordinary field stability. Theoretical expressions and corresponding experimental observations are obtained for the behavior of cavity chains operating in the π/2 mode. The synthesis of the side coupled cavity chain, a biperiodic chain which combines high acceleration efficiency with π/2 mode field stability, is described. Extensions of π/2 mode operation to nonperiodic chains is also demonstrated.
RETRACTED ARTICLE: Whole-genome assembly of Akkermansia muciniphila sequenced directly from human stool (2015)

This work highlights the potential of metagenomics to facilitate the assembly of genomes directly from human stool.
Isolation ofl-β-Phenyllactic Acid and Tyrosol as Plant Growth Regulators fromGloeosporium laeticolor (1973)

Journal Article Isolation of l-β-Phenyllactic Acid and Tyrosol as Plant Growth Regulators from Gloeosporium laeticolor Get access Yasuo Kimura, Yasuo Kimura Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Saburo Tamura Saburo Tamura Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 37, Issue 12, 1 December 1973, Page 2925, https://doi.org/10.1080/00021369.1973.10861099 Published: 01 December 1973 Article history Received: 23 July 1973 Published: 01 December 1973
Torque Vectoring AWD Driveline: Design, Simulation, Capabilities and Control (2004)

&lt;div class="htmlview paragraph"&gt;This paper reports interim developments and findings prior to completion of an extensive R&amp;amp;D program that encompasses novel driveline hardware including an electrical modulation element to bias front and rear propeller shaft torque, and the control of this type of active driveline in respect of traction and vehicle dynamics. The AWD hardware has been fitted to a BMW X5 vehicle, with a winter test planned for January 2004 prior to wider demonstration.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Specifically, the following are discussed:&lt;/div&gt; &lt;div class="htmlview paragraph"&gt; &lt;ul class="list disc"&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;The AWD market.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;Functional description of the novel torque biasing hardware including EASY5™ simulation results of the device and its influence upon the relative slip of the front and rear axles.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;Hardware elements of the variable torque bias coupling.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;Electrical system.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;Novel features such as a dual-drive lubrication system, a practical design for driveline torque sensing, and the hybrid vehicle potential of the device with additional connectivity for the e-machine.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;Simulation environment for vehicle dynamics applied with IPG™ CarMaker™ and Simulink™ RTW™. Software Implementation using ASCET-SD™.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;Traction control strategy and simulation results.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;Yaw velocity control and simulation results.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;Calibration of vehicle handling characteristics.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;Review of benchmarking data for a BMW X5.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;Novel actuation and driveline devices: MRF actuator and modulation devices for driveline.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;div class="htmlview paragraph"&gt;Conclusions to date.&lt;/div&gt;&lt;/li&gt; &lt;/ul&gt; &lt;/div&gt; &lt;div class="htmlview paragraph"&gt;On completion of this project further publications will provide validated results and further analysis. The reader will appreciate that extensive description of all project facets cannot be accommodated within the confines of a single paper.&lt;/div&gt;
Polar Solvation Dynamics in Zn(II)-Substituted Cytochromec:  Diffusive Sampling of the Energy Landscape in the Hydrophobic Core and Solvent-Contact Layer (2004)

We employed picosecond time-resolved fluorescence spectroscopy to characterize polar diffusive protein and solvent dynamics in Zn(II)-substituted cytochrome c. The solvent-response function, obtained from the dynamic Stokes shift of the Zn(II) porphyrin's fluorescence 0−0 transition energy over the 100-ps to 12-ns time scale, exhibits a double-exponential decay (250 ps and 1.45 ns time constants). The addition of glycerol to the external solvent medium slows only the slower of the two exponential components; in the presence of 50% (v/v) glycerol, the second time constant was lengthened to 2.2 ns. The magnitude of the decay accounts for 85% of the reorganization energy and leaves room for only a minor inertial component on the sub-ps time scale. The results show that two types of polypeptide motions are sensed by the intrinsic Zn(II) porphyrin. The slower of the motions arises from polypeptide motions in the interfacial, solvent-contact portion of the protein. The faster, solvent-independent part of the response arises from motions of the polypeptide in the hydrophobic core of the protein. The two classes of motion are apparently not strongly coupled, nor is the dynamic Stokes shift coupled to the nonpolar reorganization that accompanies the excited-state photodissociation of the Zn(II) porphyrin's protein-derived axial ligands. The finding that the inertial response is limited to a small fraction of the total reorganization energy suggests that the hydrophobic core of the protein is largely incapable of the free-rotor or librational character of polypeptide and solvent motions that is observed near the solvent interface.
A Distribution Function for the Particles in an Anisotropic Relativistic Plasma (1973)

The particles making up a plasma are usually not in equilibrium, and their energies are often relativistic and anisotropically distributed, especially if the plasma is in a d.c. magnetic field. Thus, the usual methods for developing particle distribution functions based on equilibrium conditions are not applicable. A development of a particular anisotropic relativistic distribution function that may describe the particles in a plasma is made.