gebhart/patrepeval huggingface dataset:
Mixing in a liquid metal electrode (2014)

Fluid mixing has first-order importance for many engineering problems in mass transport, including design and optimization of liquid-phase energy storage devices. Liquid metal batteries are currently being commercialized as a promising and economically viable technology for large-scale energy storage on worldwide electrical grids. But because these batteries are entirely liquid, fluid flow and instabilities may affect battery robustness and performance. Here we present estimates of flow magnitude and ultrasound measurements of the flow in a realistic liquid metal electrode. We find that flow does substantially affect mass transport by altering the electrode mixing time. Above a critical electrical current density, the convective flow organizes and gains speed, which promotes transport and would yield improved battery efficiency.
Characterization of Phosphor Materials for Use In Plasma Display Panel by Time-Resolved Vacuum-Ultraviolet Laser Spectrometry (2001)

Phosphor materials that were manufactured for use in a plasma display panel (PDP) were investigated by employing a newly designed time-resolved vacuum-ultraviolet (VUV) spectrometer, which consists of a pulsed VUV laser and a fast photodetector. The VUV spectrometer was used to collect quantum efficiency data as well as the rise and decay times for the PDP phosphor luminescence. Both the rise and decay times increased with decreasing excitation wavelength in the VUV region. This result can be explained by a change in the mechanisms of photoexcitation and luminescence, that is, from charge-transfer excitation to host-lattice excitation below 200 nm. The present instrument was also used for an evaluation of the phosphor materials (Ba(1 - x)MgAl10O17:Eu2+(x)) by changing the Eu2+ concentration. The obtained data suggest that the impurities and defects are located inside the host crystal. Thus, the VUV spectrometer constructed in this study has considerable potential for use in investigating the nature of PDP phosphor materials.
Self-reported pain and physical signs for musculoskeletal disorders in the upper body region among Los Angeles garment workers (2009)

Reports of pain and physical exam findings for musculoskeletal disorders (MSDs) are two common outcome measures independently used to assess work-related MSDs in the scientific literature. How these measures correlate with each other, however, is largely unknown. We recruited 520 sewing machine operators to describe the correlation between subjective self-reported pain and physical findings of MSDs in three upper body regions including the neck/shoulder, elbow/forearm, and hand/wrist. Self-reports of pain and physical findings resulted in different and partly non-overlapping classifications of subjects as MSD cases in our study. Both outcome measures were found to be consistently associated with 'having a medical history of MSDs', 'perceived physical exertion', 'perceived job insecurity' (neck/shoulder), being of older age (arm/forearm), and female gender (arm/forearm and hand/wrist); however, we observed inconsistency for the measures for a number of other job related factors such as 'operating a single machine' and 'number of work hours per week'. Because to date no agreed upon "gold standard" for diagnosing MSDs exists, our findings suggest that research results can be very different when using self-reported measures versus physical exam findings. Also, in order to evaluate the success of an intervention, screening, or surveillance program for work related MSDs, it is important to define clearly which outcome measure best to employ.
CZOCHRALSKI GROWTH AND PROPERTIES OF YAlO3 LASER CRYSTALS (1969)

Czochralski growth characteristics of a new laser host crystal, YAlO3, and measurements of its optical, thermal, and mechanical properties are reported. Stimulated emission from Nd3+ in YAlO3 has been observed.
Ultrasensitive Flexible κ-Phase Ga2O3 Solar-Blind Photodetector (2022)

Flexible Ga<sub>2</sub>O<sub>3</sub> photodetectors have attracted considerable interest owing to their potential use in the development of implantable, foldable, and wearable optoelectronics. In particular, β-phase Ga<sub>2</sub>O<sub>3</sub> has been most widely investigated due to the highest thermodynamic stability. However, high-quality β-phase Ga<sub>2</sub>O<sub>3</sub> relies on the ultrahigh crystallization temperature (usually ≥750 °C), beyond the thermal tolerance of most flexible substrates. In this work, we epitaxially grow a high-quality metastable κ-phase Ga<sub>2</sub>O<sub>3</sub> (002) thin film on a flexible mica (001) substrate under 680 °C and develop a flexible κ-Ga<sub>2</sub>O<sub>3</sub> thin film photodetector with ultrahigh performance. Epitaxial κ-Ga<sub>2</sub>O<sub>3</sub> and the mica substrate are maintained to be thermally stable up to 750 °C, suggesting their potential for harsh environment applications. The responsivity, on/off ratio, detectivity, and external quantum efficiency of the fabricated photodetector are 703 A/W, 1.66 × 10<sup>7</sup>, 4.08 × 10<sup>14</sup> Jones, and 3.49 × 10<sup>5</sup> %, respectively, for 250 nm incident light and a 20 V bias voltage. These values are record-high values reported to date for flexible Ga<sub>2</sub>O<sub>3</sub> photodetectors. Furthermore, the flexible photodetector shows robust flexibility for bending radii of 1, 2, and 3 cm. More importantly, it shows strong mechanical stability against 10,000 bending test cycles. These results reveal the significance of high-quality κ-phase Ga<sub>2</sub>O<sub>3</sub> grown heteroepitaxially on a flexible mica substrate, especially its potential for use in future flexible solar-blind detection systems.
Diagnostic power of laser speckle flowgraphy‐measured optic disc microcirculation for open‐angle glaucoma: Analysis of 314 eyes (2019)

None declared. N.A. and T.N. were involved in the design and conduct of the study; N.A. also involved in the collection, management and analysis of the data; N.A., H.K. and T.N. in interpretation of the data; H.K. in drafting, and T.N. in review and approval of the manuscript.
Effect of the non-dipole field on the seasonal variation of the geomagnetic Sq(Y) (2022)

Earth and Space Science Open Archive This preprint has been submitted to and is under consideration at Journal of Geophysical Research - Space Physics. ESSOAr is a venue for early communication or feedback before peer review. Data may be preliminary.Learn more about preprints preprintOpen AccessYou are viewing the latest version by default [v1]Effect of the non-dipole field on the seasonal variation of the geomagnetic Sq(Y)AuthorsLinTianiDAiminDuShengHuangHaoLuoiDWen-yaoXuYasong SGeSee all authors Lin TianiDInstitute of Geology and Geophysics, Chinese Academy of SciencesiDhttps://orcid.org/0000-0001-9568-5054view email addressThe email was not providedcopy email addressAimin DuInstitue of Geology and Geophysics, Chinese Academy of Sciencesview email addressThe email was not providedcopy email addressSheng HuangKey Laboratory of Earth and Planetary Physics, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, Chinaview email addressThe email was not providedcopy email addressHao LuoiDCorresponding Author• Submitting AuthorInstitute of Geology and Geophysics, Chinese Academy of SciencesiDhttps://orcid.org/0000-0002-1446-6085view email addressThe email was not providedcopy email addressWen-yao XuInstitute of Geology and Geophysics, Chinese Academy of Sciencesview email addressThe email was not providedcopy email addressYasong S GeInstitute of Geology and Geophysicsview email addressThe email was not providedcopy email address
ChemInform Abstract: Room‐Temperature Ionic Liquids: Neoteric Solvents for Clean Catalysis (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High temperature growth of ZnS films on bare Si and transformation of ZnS to ZnO by thermal oxidation (2001)

ZnS films were grown on Si (100) at high temperatures by pulsed laser deposition using a KrF excimer laser. The growth temperature was varied from 200 to 700 °C and all films were found to have a specific preferential orientation. With increasing Ts, growth rate decreased but the quality of the film improved. The highest quality ZnS film was obtained at 700 °C. The presence of ZnS+ ions among the ablation products of a ZnS target was verified by laser desorption time of flight mass spectroscopy measurements. ZnO was formed by thermal oxidation of ZnS and the films showed strong near band-edge emission at 3.26 eV.
Leaky-Wave Antennas Using Negative-Refractive-Index Transmission-Line Metamaterial Supercells (2014)

Leaky-wave antennas (LWAs) are designed based on supercells which are expanded versions of conventional negative-refractive-index transmission line (NRI-TL) unit cells. In the proposed LWAs with NRI-TL supercells, the number and values of inductors are reduced by half, decreasing the complexity of their design and reducing the Ohmic loss, which increases the antenna gain and efficiency. Compared with conventional NRI-TL unit cells, NRI-TL supercells operate over narrower bandwidth while showing proper Bloch impedance behavior over both left-hand (LH) and right-hand (RH) regions, leading to broadband impedance matching. Using coplanar waveguide (CPW) technology, closed-stopband LWAs based on NRI-TL supercells are designed, and their performance compared with that of the conventional unit cell LWAs. Finally, by using CPW supercells with a backing ground and vias, high-gain LWAs with sharp beams and suppressed backlobes are designed and realized.
LANCL2 Is Necessary for Abscisic Acid Binding and Signaling in Human Granulocytes and in Rat Insulinoma Cells (2009)

Abscisic acid (ABA) is a plant hormone regulating fundamental physiological functions in plants, such as response to abiotic stress. Recently, ABA was shown to be produced and released by human granulocytes, by insulin-producing rat insulinoma cells, and by human and murine pancreatic beta cells. ABA autocrinally stimulates the functional activities specific for each cell type through a receptor-operated signal transduction pathway, sequentially involving a pertussis toxin-sensitive receptor/G-protein complex, cAMP, CD38-produced cADP-ribose and intracellular calcium. Here we show that the lanthionine synthetase C-like protein LANCL2 is required for ABA binding on the membrane of human granulocytes and that LANCL2 is necessary for transduction of the ABA signal into the cell-specific functional responses in granulocytes and in rat insulinoma cells. Co-expression of LANCL2 and CD38 in the human HeLa cell line reproduces the ABA-signaling pathway. Results obtained with granulocytes and CD38(+)/LANCL2(+) HeLa transfected with a chimeric G-protein (G alpha(q/i)) suggest that the pertussis toxin-sensitive G-protein coupled to LANCL2 is a G(i). Identification of LANCL2 as a critical component of the ABA-sensing protein complex will enable the screening of synthetic ABA antagonists as prospective new anti-inflammatory and anti-diabetic agents.
Maturation conditions do not affect Myst1, Hat1, and Sirt1 mRNA abundance in horse oocytes (2014)

Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)
L'extension artificielle des côtes vers le large et ses conséquences en droit international (2005)

La thèse aborde une question originale et d'actualité: l'extension artificielle des côtes. Afin de mieux comprendre ce phénomène dans son actualité, la thèse attache une importance à la description de la pratique des États en fournissant les informations aussi précises, aussi actuelles et aussi concrètes que possible. C'est à partir de cette pratique que la thèse répond à la question de savoir comment les règles de droit répondent aux exigences de la pratique. En ce qui concerne la pratique des États, la thèse explique, dans une première partie, que l'extension artificielle des côtes est destinée, tantôt, à protéger les côtes contre l'élévation du niveau de la mer, tantôt à gagner des terres pour diverses fins: habitat humain, agricoles, développement des ports et de leurs infrastructures pour les besoins des navires modernes et du commerce international. Mais parallèlement, cette extension entraîne des effets négatifs pour l'écosystème côtier (chapitre I). Des travaux de ce genre ont été menés, ou vont l'être, en Europe (Pays-Bas, Allemagne, Belgique, France, R.-U. etc), aux États-Unis, en Asie (Bahreïn, Malaisie, Hong Kong, Singapour, Japon), en Australie, et sur certains archipels du Pacifique (chapitre II). La seconde partie de la thèse examine le droit applicable au phénomène d'extension artificielle des côtes. Sont ainsi passées en revue: les règles relatives à la navigation (chapitre III), les règles relatives aux lignes de base (chapitre IV), les règles relatives aux hauts-fonds découvrants (chapitre V), les règles relatives aux îles et aux rochers (chapitre VI) et enfin les règles relatives à la protection de l'environnement marin (chapitre VII).
Gradient Sensitive Microscopic Probes Prepared by Gold Evaporation and Chemisorption on Latex Spheres (1997)

We describe a simple yet general method for preparing microscopic probes that are gradient sensitive. Gold was first evaporated on one side of latex spheres, which were then chemically modified by a thiol. As one example, by using thiols with ionizable groups, we prepared microscopic spheres with pH dependent electric dipole moments. Under an electric field such spheres reoriented themselves depending on the pH value of the environment. This method can be naturally extended to other thiol-modified molecules such as dyes and antibodies to prepare various probes that are sensitive to the gradient of the physicochemical microenvironment or that are directional in binding.
Wideband FDTD-Based Adjoint Sensitivity Analysis of Dispersive Electromagnetic Structures (2014)

We propose a wideband adjoint variable method for sensitivity analysis of dispersive structures utilizing finite difference time domain (FDTD). Using only one extra FDTD simulation, the sensitivities of the desired response are estimated over the frequency band of interest with respect to all the design parameters. The presented theory is based on direct discretization of Maxwell's equations. We derive the equations of the adjoint system for problems with different types of dispersion profiles including the Lorentz, Drude, and Debye models. The validation of our approaches is done through comparison with the expensive finite-difference approach applied at the response level.
The interactions of Bcl9/Bcl9L with β-catenin and Pygopus promote breast cancer growth, invasion, and metastasis (2021)

Canonical Wnt/β-catenin signaling is an established regulator of cellular state and its critical contributions to tumor initiation, malignant tumor progression and metastasis formation have been demonstrated in various cancer types. Here, we investigated how the binding of β-catenin to the transcriptional coactivators B-cell CLL/lymphoma 9 (Bcl9) and Bcl9-Like (Bcl9L) affected mammary gland carcinogenesis in the MMTV-PyMT transgenic mouse model of metastatic breast cancer. Conditional knockout of both Bcl9 and Bcl9L resulted into tumor cell death. In contrast, disrupting the interaction of Bcl9/Bcl9L with β-catenin, either by deletion of their HD2 domains or by a point mutation in the N-terminal domain of β-catenin (D164A), diminished primary tumor growth and tumor cell proliferation and reduced tumor cell invasion and lung metastasis. In comparison, the disruption of HD1 domain-mediated binding of Bcl9/Bcl9L to Pygopus had only moderate effects. Interestingly, interfering with the β-catenin-Bcl9/Bcl9L-Pygo chain of adapters only partially impaired the transcriptional response of mammary tumor cells to Wnt3a and TGFβ treatments. Together, the results indicate that Bcl9/Bcl9L modulate but are not critically required for canonical Wnt signaling in its contribution to breast cancer growth and malignant progression, a notion consistent with the "just-right" hypothesis of Wnt-driven tumor progression.
Data from AraC-FdUMP[10] Is a Next-Generation Fluoropyrimidine with Potent Antitumor Activity in PDAC and Synergy with <i>PARG</i> Inhibition (2023)

&lt;div&gt;Abstract&lt;p&gt;AraC-FdUMP[10] (CF10) is a second-generation polymeric fluoropyrimidine that targets both thymidylate synthase (TS), the target of 5-fluorouracil (5-FU), and DNA topoisomerase 1 (Top1), the target of irinotecan, two drugs that are key components of FOLFIRNOX, a standard-of-care regimen for pancreatic ductal adenocarcinoma (PDAC). We demonstrated that F10 and CF10 are potent inhibitors of PDAC cell survival (in multiple cell lines including patient-derived lines) with IC&lt;sub&gt;50&lt;/sub&gt;s in the nanomolar range and are nearly 1,000-fold more potent than 5-FU. The increased potency of CF10 relative to 5-FU correlated with enhanced TS inhibition and strong Top1 cleavage complex formation. Furthermore, CF10 displayed single-agent activity in PDAC murine xenografts without inducing weight loss. Through a focused drug synergy screen, we identified that combining CF10 with targeting the DNA repair enzyme, poly (ADP-ribose) glycohydrolase, induces substantial DNA damage and apoptosis. This work moves CF10 closer to a clinical trial for the treatment of PDAC.&lt;/p&gt;Implications:&lt;p&gt;CF10 is a promising polymeric fluoropyrimidine with dual mechanisms of action (i.e., TS and Top1 inhibition) for the treatment of PDAC and synergizes with targeting of DNA repair.&lt;/p&gt;&lt;/div&gt;
[Prevention and treatment of nonsteroidal anti-inflammatory drug-induced gastric ulcers with proton pump inhibitor]. (2007)

Nonsteroidal anti-inflammatory drug is usefulness, but it was well known that have often complicated gastric ulcers. Proton pump inhibitors (PPI) have gained worldwide popularity for the suppression of gastric acid production. PPI is used and shows most efficacies for gastric ulcer. In this paper we would like to discuss about prevention and treatment of nonsteroidal anti-inflammatory drug-induced gastric ulcers with PPI.
Pharmacokinetics of nimesulide (2005)

Nimesulide (4-nitro-2-phenoxymethanesulfonanilide) is a non-acidic, non-steroidal anti-inflammatory drug (NSAID) usually administered orally in the form of tablets and granules (sachets). The normal dosage is 100 mg twice daily. Rectal administration of suppositories is also employed, although to a minor extent. Normal dosage for rectal administration is 200 mg twice daily. In some countries, a suspension of nimesulide and a topical formulation (gel) are also commercially available. Pharmacokinetic studies have been performed with all these formulations. Comprehensive reviews have been published on nimesulide pharmacokinetics in healthy volunteers after single and multiple administration [1–3], and on the effect of age and disease on the pharmacokinetic variables [4, 5]. This chapter provides an up-to-date description of the processes related to nimesulide absorption, distribution, metabolism and elimination in animal species and in humans.
Pharmacological chaperones for human α- N -acetylgalactosaminidase (2012)

Schindler/Kanzaki disease is an inherited metabolic disease with no current treatment options. This neurologic disease results from a defect in the lysosomal α-N-acetylgalactosaminidase (α-NAGAL) enzyme. In this report, we show evidence that the iminosugar DGJNAc can inhibit, stabilize, and chaperone human α-NAGAL both in vitro and in vivo. We demonstrate that a related iminosugar DGJ (currently in phase III clinical trials for another metabolic disorder, Fabry disease) can also chaperone human α-NAGAL in Schindler/Kanzaki disease. The 1.4- and 1.5-Å crystal structures of human α-NAGAL complexes reveal the different binding modes of iminosugars compared with glycosides. We show how differences in two functional groups result in >9 kcal/mol of additional binding energy and explain the molecular interactions responsible for the unexpectedly high affinity of the pharmacological chaperones. These results open two avenues for treatment of Schindler/Kanzaki disease and elucidate the atomic basis for pharmacological chaperoning in the entire family of lysosomal storage diseases.
Testing with Large Parameter Sets for the Development of Embedded Systems in the Automation Domain (2009)

Testing of current devices in the automation domain cannot be done mathematically exhaustive due to the huge number of possible test cases and, even more important, the tremendous amount of time for the execution of all test cases.Thus, a dramatic reduction is needed in the testing domain.This paper discusses two possibilities for the reduction of test case execution time by reducing the number of rdquoparameter setrdquo permutations, recursive backtracking and pairwise testing.Testing of devices in the automation domain is based on their behavior (black box testing) and the parameters of the devices,which influence the behavior.The combination of a parameter model including constraints between parameters, recursive backtracking and pairwise testing can result in the reduction of the parameter permutation space by more than 99%. This paper presents the current status of this reduction and proposes a future direction towards a structured reduction of test cases based on the reduction of the rdquoparameter setrdquo permutations.
Anti‐tumor polysaccharides from mushrooms during storage (2000)

The changes in the contents of an anti-tumor polysaccharide from Lentinus edodes (lentinan) and Grifolafrondosa (GGF) during storage were investigated using by an ELISA inhibition assay. When the mushrooms were stored at low temperature, the contents of their anti-tumor polysaccharides show hardly any changes, but their contents decreased markedly at higher temperature (20 degrees C). Moreover, the effect of the extract from Lentinus edodes stored at different temperatures on tumor necrosis factor (TNF)-alpha and nitric oxide (NO) productions from macrophages was investigated to confirm the influence to the stimulation of macrophages. Because lentinan stimulates macrophages to augment their antitumor activity. Their productions showed little difference between Lentinus edodes stored at low temperature and the fresh mushroom, although the cytokine production decreased significantly in Lentinus edodes stored at 20d egrees C. These results suggest that low-temperature storage is more effective in maintaining not only the quality of the mushrooms but also the contents of anti-tumor polysaccharides as health-beneficient foods.
A method for full wave analysis of electrically large transparent radomes (2016)

The paper presents a method for the efficient full wave analysis of electrically large transparent radomes. MoM SIE based code is used for the analyses and the special technique is used for reduction of number of unknown coefficients. Namely, only the part of the radome which is illuminated by main and significant side lobes is taken into account, while remaining parts are excluded from the analysis. Accuracy of the proposed method is confirmed by comparison of simulation results obtained without reduction. Diameter of radome which analysis is presented is about 110 wavelengths.