gebhart/patrepeval huggingface dataset:
CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress (2020)

Cancer cell adaptation to stresses such as nutrient deprivation, hypoxia, and chemotherapy can critically contribute to dormancy, metastasis, therapy resistance, and recurrence. Identifying mechanisms that govern cellular adaptation, plasticity, and the emergence of stem-like cancer cells may be key to effective anticancer therapies. Results presented here indicate that targeting CRIPTO with ALK4<sup>L75A</sup>-Fc may have potential as such a therapy since it inhibits breast cancer cell adaptation to microenvironmental challenges and associated stem-like and EMT phenotypes.
Effect of Policosanol on Circulating Endothelial Cells in Experimental Models in Sprague-Dawley Rats and in Rabbits (1997)

The effect of policosanol on circulating endothelial cells has been studied in different experimental models with endothelium damage. Oral administration of 25 mg kg-1 policosanol to Sprague-Dawley rats resulted in significant protection of the endothelial lining against the desquamating effect of citrate. Oral administration of 5 mg kg-1 policosanol to spontaneously hypertensive rats (SHR) resulted in a significant reduction of circulating endothelial cells compared with controls. Moreover, comparison between groups revealed a lower frequency of aortic lesions in policosanol-treated animals than in controls. On the other hand, administration of 5 mg kg-1 policosanol to rabbits with intimal hyperplasia induced by cuff placement in the carotid artery resulted in levels of circulating endothelial cells significantly lower than in controls. These results demonstrate the protective effect of policosanol in different experimental models and suggest its potential for endothelial protection.
A MRI spatial mapping technique for microvascular permeability and tissue blood volume based on macromolecular contrast agent distribution (1997)

A rapid and automated method for two-dimensional spatial depiction (mapping) of quantitative physiological tissue characteristics derived from contrast enhanced MR imaging was developed and tested in disease models of cancer, inflammation, and myocardial reperfusion injury. Specifically, an established two-compartment kinetic model of unidirectional mass transport was implemented on a pixel-by-pixel basis to generate maps of tissue permeability surface area product (PS) and fractional blood volume (BV) based on dynamic MRI intensity data after administration of albumin-(Gd-DTPA)30, a prototype macromolecular contrast medium (MMCM) designed for blood pool enhancement. Maps of PS and BV in disease models of adenocarcinoma, intramuscular abscess inflammation, and myocardial reperfusion injury clearly depicted zones of increased permeability (up to approximately 500 microl/cc/h--compared to <25 microl/cc/h in normal tissues). As revealed on PS maps, the rank ordering of studied permeability abnormalities was reperfusion injury > inflammation > tumors. A rapid, automated mapping technique derived from dynamic contrast-enhanced MRI data can be used to facilitate the identification and characterization of pathophysiologic abnormalities, specifically relative increases in blood volume and/or microvascular permeability.
Robust multi-view camera calibration for wide-baseline camera networks (2011)

Real-world camera networks are often characterized by very wide baselines covering a wide range of viewpoints. We describe a method not only calibrating each camera sequence added to the system automatically, but also taking advantage of multi-view correspondences to make the entire calibration framework more robust. Novel camera sequences can be seamlessly integrated into the system at any time, adding to the robustness of future computations. One of the challenges consists in establishing correspondences between cameras. Initializing a bag of features from a calibrated frame, correspondences between cameras are established in a two-step procedure. First, affine invariant features of camera sequences are warped into a common coordinate frame and a coarse matching is obtained between the collected features and the incrementally built and updated bag of features. This allows us to warp images to a common view. Second, scale invariant features are extracted from the warped images. This leads to both more numerous and more accurate correspondences. Finally, the parameters are optimized in a bundle adjustment. Adding the feature descriptors and the optimized 3D positions to the bag of features, we obtain a feature-based scene abstraction, allowing for the calibration of novel sequences and the correction of drift in single-view calibration tracking. We demonstrate that our approach can deal with wide baselines. Novel sequences can seamlessly be integrated in the calibration framework.
A Study of Factors Controlling Physical Properties of Mozzarella Cheese and the Manufacture of a Reduced Fat Mozzarella Cheese (2021)

Variables affecting the physical properties of Mozzarella cheese were investigated. The effects of various milk-clotting enzymes were examined. The type of milk coagulating enzyme used played a significant role in determining physical properties of direct acid Mozzarella cheese. Cook color was not affected by enzyme type, but melt and stretch were significantly affected. Proteolytic nature of starter cultures was reviewed and recommendation s were give n. Cheese made with proteinase-deficient strains had more stretch after holding for 14 and 28 d than cheese made with non-deficient strains. Cheese made with pairs or single strains of L. helveticus had the same melt, more stretch, and less cook color than cheeses made with paired strains of Lactobacillus delbrueckii ssp. bulgaricus and Streptococcus salivarius ssp. thermophilus. Frozen storage, thawing, and shredding of Mozzarella cheese were described and suggestions given for optimizing shelf life. Shredding, freeze temperature, thaw temperature , and time of storage had no effect on cook color. Frozen, shredded cheese stretched more and melted less than non-shredded frozen cheese. Reduced fat, high moisture Mozzarella cheese was made and found acceptable when compared to low moisture part-skim Mozzarella cheese. Reduced fat cheeses decreased in stretch and increased in melt throughout storage. Differences in stretch, melt, and cook color were not significant from one casein-to-fat ratio to another. Reduced fat, high moisture Mozzarella cheese was made with partial or total replacement of L. helveticus with L. casei ssp. casei and was found to compare well with low moisture part-skim Mozzarella cheese. Cheese made with L. casei ssp. casei cultures, paired with either S. salivarius ssp. thermophilus and L. helveticus or just S. salivarius ssp. thermophilus, had the least stretch and the greatest melt.
Force Modulating Tissue Bridges for Reduction of Tension and Scar: Finite Element and Image Analysis of Preclinical Incisional and Nonincisional Models (2018)

FMTBs provide wounds while simultaneously modulating skin tension and thus have the potential to improve scar appearance.
A protective effect of EBG on rat brain (2003)

The pathological mechanism of ischemic neuronal damage and death is more complicated and has not completely clear. We study the effect of EGB on the neurologic impairment,water containing level, infarct volume,pathological change by the animal model of middle cerebral artery (MCAo)ischemia/reperfusion . The results show that the EGB has a obvious beneficial effect on focal ischemia/reperfusion.
P‐103: Novel Poly‐Si TFT Pixel Electrode Circuits and Current Programmed Active‐Matrix Driving Methods for AM‐OLEDs (2002)

Abstract In this paper, we present the systematic analysis of the current‐programmed poly‐Si pixel electrode circuits with current‐sink‐type charging functionality and duty ratio controllability. Two different driving schemes for top‐cathode and top‐anode organic light‐emitting device structures are described and compared. Their limitations and advantages are also discussed.
Electronically controlled long leg brace (2002)

Long leg braces are prescribed for those incapable of ambulation due to quadriceps insufficiency or paralysis. These designs lock the knee joint and require the user to adopt an unnatural and energy inefficient gait. A self-contained, electronically controlled brace system has been designed and tested which allows knee flexion during the swing phase of gait, but restricts flexion during the stance, or weight-bearing, phase. Laboratory test results comparing this new brace system and a standard locked Knee-Ankle-Foot-Orthosis show that knee flexion/extension kinematics are improved and that oxygen consumption rates are reduced.
Synthesis and biological evaluation of analogues of butyrolactone I and molecular model of its interaction with CDK2 (2004)

A series of analogues of butyrolactone I, a natural product isolated from Aspergillus terreus that selectively inhibits the CDK2 and CDK1 kinases and that has been found to exhibit an interesting antiproliferative activity, have been synthesized. Its antitumor activity has been tested. Molecular models of the complex between butyrolactone I and the CDK2 active site have been built using a combination of conformational search and automated docking techniques. The stability of the resulting complexes has been assessed by molecular dynamics simulations and the experimental results obtained for the synthesized analogues are rationalized based on the molecular models.
Perforierende Augenverletzungen mit multiplen intraokularen Fremdkörpern nach Manöverunfällen* (1986)

Nine patients sustained massive ocular injuries mostly bilateral, caused by practice ammunition fragments during military maneuvers. The injuries consisted of severe contusion and perforation damage to the cornea, traumatic cataract, vitreous hemorrhage, and multiple small intraocular foreign bodies frequently impacting on or penetrating the retina. Extraction of the foreign bodies was difficult, usually because they could not be localized preoperatively, because of optical problems due to corneal opacifications and frequent hemorrhages, and because of a lack of posterior vitreous detachment. Nevertheless, in the 15 eyes which underwent secondary surgery travel vision (1/35 to 0.2) was achieved in three and good visual acuity (0.3 to 1.0) in eight. Only four eyes ended up with practical blindness (LP to hand movements) due to retinal traction detachments with proliferative vitreoretinopathy.
Preparação e caracterização de nanocapsulas de poly(D,L-lactideo) no encapsulamento de palmitato de retinila (2009)

Nesse trabalho, foram preparadas nanocapsulas (NC) que consistem em um nucleo oleoso (sistema reservatorio) e uma parede polimerica, nas quais se empregou o oleo palmitato de retinila (PR) e o polimero biodegradavel poli(D,L-lactideo) (PLA). Alem desse sistema, nanoemulsoes (NE, sem a parede polimerica) e nanoesferas (NS, matriz polimerica) foram preparadas para efeito de comparacao. Utilizou-se ainda, moleculas modelos solubilizadas no nucleo oleoso do PR, a benzofenona-3 (BZ3) e a baicaleina (BAI). As NC foram caracterizadas quanto a eficiencia de encapsulamento, estabilidade fisica e quimica, distribuicao de tamanhos e potencial zeta. As NC e NE apresentaram tamanhos medios de 200 nm (P.D.I=0,1), potencial zeta de aproximadamente -10 mV (emprego de surfactante nao-ionico), sendo estaveis fisico-quimicamente por 4 meses a aproximadamente 4 °C e 28 °C. Realizou-se ensaios de citotoxicidade e fototoxicidade das nanoestruturas em queratinocitos (HaCat) e fibroblastos (BALB/c 3T3), observando-se que as NC apresentam citotoxicidade apenas a elevadas concentracoes, sendo assim, apresentam-se viaveis para aplicacao dermica. Medidas de calorimetria diferencial de varredura (DSC) evidenciaram que as nanoestruturas apresentam abaixamento de picos de fusao em comparacao as misturas fisicas e que devido a baixa proporcao, a BZ3 nao influencia os eventos termicos das nanoestruturas, enquanto que o surfactante Span 60 aumenta a largura do pico de fusao do PR, o que sugere sua solubilizacao no nucleo das NC. A analise morfologica das particulas pela tecnica de microscopia eletronica de transmissao (TEM) mostrou que as NC apresentam capacidade de deformacao. Para melhor investigacao desta propriedade, utilizou-se experimento de extrusao em membranas de poros de menores tamanhos. No ensaio, observou-se que as NC permeiam as membranas de policarbonato quando adicionado PEG-8L, um surfactante empregado para aumentar a permeacao de lipossomas elasticos devido ao aumento da molhabilidade dos poros da membrana. Preparou-se o derivativo polimerico com o cromoforo azul do Nilo (AN) atraves da formacao de ligacao covalente dos acidos carboxilicos terminais e amina do AN. Tal polimero foi empregado em ensaio de permeacao cutânea por celula de difusao vertical de Franz e sua avaliacao por microscopia de varredura a laser confocal (CLSM). Os ensaios revelaram que a fluorescencia da parede polimerica e a do PR apresentam-se em mesma profundidade na pele, o que evidencia a permeacao do carreador ao inves de uma liberacao do ativo. Em quantificacao das NC na pele, observou-se que, o PR atinge a celula receptora e e encontrado em camadas da epiderme/derme e camada cornea. Desta forma, esse trabalho contribuiu atraves da obtencao de um sistema de NC bastante promissor para o armazenamento da vitamina A, bem como no carreamento de bioativos a camadas mais profundas da pele. 
Abstract
The new CCD Zenith Tube (2007)

Abstract The reconstruction of the Photographic Zenith Tube (PZT) at Ondřejov has been finished recently. The main improvement of the instrument consists in the replacement of the photographic plate with the CCD chip, and a completely new electronic control system. In addition to the astrometric use of the observations we intend to derive the variations of the local vertical and compare them with gravimetric observations of the nearby station Pecný.
Goal-Aware RSS for Complex Scenarios via Program Logic (2022)

We introduce a <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">goal-aware</i> extension of responsibility-sensitive safety (RSS), a recent methodology for rule-based safety guarantee for automated driving systems (ADS). Making RSS rules guarantee goal achievement—in addition to collision avoidance as in the original RSS—requires complex planning over long sequences of manoeuvres. To deal with the complexity, we introduce a compositional reasoning framework based on program logic, in which one can systematically develop RSS rules for smaller subscenarios and combine them to obtain RSS rules for bigger scenarios. As the basis of the framework, we introduce a program logic <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\text{dFHL}$</tex-math></inline-formula> that accommodates continuous dynamics and safety conditions. Our framework presents a <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\text{dFHL}$</tex-math></inline-formula> -based workflow for deriving goal-aware RSS rules; we discuss its software support, too. We conducted experimental evaluation using RSS rules in a safety architecture. Its results show that goal-aware RSS is indeed effective in realising both collision avoidance and goal achievement.
Ultra-long-haul transmission of 7×429 Gbit/s PS-QPSK and PDM-BPSK (2011)

We investigated ultra-long-haul transmission of polarization-switched QPSK (PS-QPSK) and polarization-division-multiplexed BPSK (PDM-BPSK) at 42.9 Gbit/s experimentally as well as by means of computer simulations. PDM-BPSK allowed transmission distances in excess of 14,040 km to be achieved, compared to 13,640 km for PS-QPSK. However, PS-QPSK offers a significant reduction in receiver complexity due to the lower symbol-rate.
Heuristic algorithms for the unconstrained binary quadratic programming problem (1998)

In this paper we consider the unconstrained binary quadratic programming problem. This is the problem of maximising a quadratic objective by suitable choice of binary (zero-one) variables. We present two heuristic algorithms based upon tabu search and simulated annealing for this problem. Computational results are presented for a number of publically available data sets involving up to 2500 variables. An interesting feature of our results is that whilst for most problems tabu search dominates simulated annealing for the very largest problems we consider the converse is true. This paper typifies a &amp;quot;multiple solution technique, single paper&amp;quot; approach, i.e. an approach that within the same paper presents results for a number of different heuristics applied to the same problem. Issues relating to algorithmic design for such papers are discussed. Keywords: unconstrained binary (zero-one) quadratic programming
Treating phenylketonuria by a phenylalanine-free diet. (1998)

The phenylalanine-free diet is needed for the treatment of phenylketonuria. Phenylketonuria is an inherited metabolic condition in which there is a deficiency of the enzyme phenylalanine hydroxylase. Lack of this enzyme means the body cannot metabolise the essential amino acid phenylalanine, which then builds up in the blood and causes mental retardation and other abnormalities. Retardation can be prevented if phenylketonuria is diagnosed in the first three weeks of infancy and dietary treatment started straightaway. There is a universal screening test in the UK (the Guthrie test). Heel-prick blood samples are taken from all babies between 6-14 days old and analysed at a regional screening centre. For infants, a phenylalanine-free formula is needed, either as a supplement before breast feeds or following a formula feed. The diet must continue during weaning and childhood, with a low protein diet. Foods such as meat, fish, eggs, milk, cheese, nuts and pulses are excluded as they contain high levels of phenylalanine. Vegetables and fruit are allowed in measured amounts only! Special low protein bread, pasta, biscuits and flour are used to supplement the diet and ensure adequate calorie intake. Whether the diet can be stopped at the end of adolescence is debatable. If stopped, it should be re-started at conception and maintained during pregnancy, as high levels of phenylalanine in the mother can affect the fetus.
A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland (2015)

Activation of an apical Ca(2+)-activated Cl(-) channel (CaCC) triggers the secretion of saliva. It was previously demonstrated that CaCC-mediated Cl(-) current and Cl(-) efflux are absent in the acinar cells of systemic Tmem16A (Tmem16A Cl(-) channel) null mice, but salivation was not assessed in fully developed glands because Tmem16A null mice die within a few days after birth. To test the role of Tmem16A in adult salivary glands, we generated conditional knockout mice lacking Tmem16A in acinar cells (Tmem16A(-/-)). Ca(2+)-dependent salivation was abolished in Tmem16A(-/-) mice, demonstrating that Tmem16A is obligatory for Ca(2+)-mediated fluid secretion. However, the amount of saliva secreted by Tmem16A(-/-) mice in response to the β-adrenergic receptor agonist isoproterenol (IPR) was comparable to that seen in controls, indicating that Tmem16A does not significantly contribute to cAMP-induced secretion. Furthermore, IPR-stimulated secretion was unaffected in mice lacking Cftr (Cftr(∆F508/∆F508)) or ClC-2 (Clcn2(-/-)) Cl(-) channels. The time course for activation of IPR-stimulated fluid secretion closely correlated with that of the IPR-induced cell volume increase, suggesting that acinar swelling may activate a volume-sensitive Cl(-) channel. Indeed, Cl(-) channel blockers abolished fluid secretion, indicating that Cl(-) channel activity is critical for IPR-stimulated secretion. These data suggest that β-adrenergic-induced, cAMP-dependent fluid secretion involves a volume-regulated anion channel. In summary, our results using acinar-specific Tmem16A(-/-) mice identify Tmem16A as the Cl(-) channel essential for muscarinic, Ca(2+)-dependent fluid secretion in adult mouse salivary glands.
The structure of nystatin A2 (2005)

The structure of nystatin A 2 was established on the basis of NMR studies which contained DQF-COSY, ROESY, HSQC and HMBC experiments.
Folic acid and cancer risk in BRCA1 carriers (2012)

Recent studies indicate that the selected micro-and macro-elements and vitamins may significantly influence the risk of cancer. Folic acid is necessary for DNA synthesis and repair, plays an important role in one-carbon groups for methylation reactions. The MTHFR gene produces an enzyme important in folate metabolism.

The aim of study was to analyze an association of folic acid concentrations and genetic variants in the MTHFR gene with breast cancer risk in patients with BRCA1 mutation.

Study group consisted of 99 patients with breast or ovarian cancer and 198 healthy women from the paired control group; all cases and controls were carriers of one out of three Polish founder mutations (C61G, 4153delA, 5382insC). Folic acid concentration was quantitatively measured in blood plasma by HPLC chromatography (Flexar HPLC, Perkin Elmer). Two functional SNPs in the MTHFR gene, 677 C>T (rs1801133) and 1298 A>C (rs1801131), both associated with reduced enzyme activity, have been tested on LightCycler 480 (Roche Diagnostic) by Taqman or Simple Probe approach.

The mean levels of folic acid were compared for cases and controls. Women who have level of folic acid in the range of 53.3 mg/l - 83.1 mg/l had a significantly lower risk of breast or ovarian cancer (OR = 0.55, p = 0.0087) – comparison to quartile with the lowest concentration. The analysis of correlation between the level of folic acid and tested genetic variants in the MTHFR gene gave the following results:

- for carriers of MTHFR 1298AA the lowest risk of cancer was for folic acid concentration >81 mg/l (OR = 0,25, p = 0,0292 , CI = 0,07948-0,7863)



Table 1



- for carriers of MTHFR 1298AA +AC the lowest risk of cancer was for folic acid concentration in the range of 51,44 to 82-82 mg/l (OR = 0,25, p = 0,009, CI = 0,09-0,67)



Table 2
An Efficient Solution to Cyclic Scheduling of a No-Wait Reentrant Serial-Parallel PCB Production Line (2007)

The manufacturing of printed circuit boards (PCB) involves multi-stage production lines where material handling is performed by a computer-controlled hoist. This paper addresses cyclic scheduling of a no-wait reentrant serial-parallel production line in PCB manufacturing. A reentrant serial-parallel production line is a production system with reentrant and parallel stations. A reentrant station is a processing station visited by parts more than once, and parallel stations are a group of stations performing the same processing at some bottleneck production stage. We first formulate our scheduling problem using the notion of prohibited intervals, and then perform a formal analysis on the developed mathematical model. Based on this analysis, we propose a polynomial algorithm for the considered problem. An illustrative example is given to verify the proposed algorithm.
Reaction of 19-Hydroxysteroids with Diethylaminosulfur Trifluoride. (1991)

抄録
Improving object transparent vision using enhanced image selection (2015)

In this paper we try to improve object transparent vision. Our goal is to see how object transparent vision can be improved by: 1. Automated fused image correctness check. 2. Finding correct images for image fusing. We also conducted several experiments related to object transparent vision in order to gain better understanding of subject. The introduced improvements in the paper can provide reasonable result for image fusion for most of the analyzed cases.