gebhart/patrepeval huggingface dataset:
Efficient thermal simulation for run-time temperature tracking and management (2006)

As power density increases exponentially, run-time regulation of operating temperature by dynamic thermal management becomes imperative. This paper proposes a novel approach to real-time thermal estimation at chip level for efficient dynamic thermal management in lieu of the thermal sensors, which are erroneous and having longer delays. Our new approach is based on the observation that the average power consumption of architecture level modules in microprocessors running typical workloads determines the trend of temperature variations. Such a feature can be exploited by applying fast moment matching technique in frequency domain. To obtain the transient temperature changes due to initial condition and constant power input pattern, numerically stable moment matching approach is carried out to speed up on-line temperature tracking with high accuracy and low overhead. The resulting fast thermal analysis algorithm has linear time complexity in run-time setting and leads to about two orders of magnitude speed-up over traditional integration-based transient analysis. The average maximum error under running typical benchmarks is only about 0.37/spl deg/C as compared to other well-accepted simulation tools.
Corrosion Behavior of Ti and Zr in Dissolution Process for Spent Nuclear Fuel Reprocessing (1985)

KEYWORDS: corrosioncorrosion resistancecorrosion potentialpolarization curvetitaniumzirconiumdissolver solutionrutheniumreprocessing
Prevalence, gender correlates, and co-morbidity of trichotillomania (2020)

Trichotillomania is a mental health condition characterized by repetitive pulling out of one's hair, often leading to functional impairment and/or distress. A convenience sampling of 10,169 adults, aged 18-69 years, representative of the general US population, completed a survey to establish occurrence of trichotillomania, other mental health concerns, and impact of the illness. 175 (1.7%) identified as having current trichotillomania. Rates of trichotillomania did not differ significantly based on gender (1.8% of males and 1.7% of females). The mean age of onset for trichotillomania was 17.7 years. The mean age of onset differed significantly for males (mean 19.0 years) versus females (mean 14.8 years (p = 0.020). The average amount of distress reported due to trichotillomania was relatively high, and 79% of people with trichotillomania had one or more mental health comorbidities, the most common being anxiety/depressive disorders, OCD, PTSD, and ADHD. This study suggests trichotillomania is relatively common in the general population and typically characterized by moderate-high distress and high rates of comorbidity.
Visualization of Polarized Membrane Type 1 Matrix Metalloproteinase Activity in Live Cells by Fluorescence Resonance Energy Transfer Imaging (2008)

Membrane type 1 matrix metalloproteinase (MT1-MMP) plays a critical role in cancer cell biology by proteolytically remodeling the extracellular matrix. Utilizing fluorescence resonance energy transfer (FRET) imaging, we have developed a novel biosensor, with its sensing element anchoring at the extracellular surface of cell membrane, to visualize MT1-MMP activity dynamically in live cells with subcellular resolution. Epidermal growth factor (EGF) induced significant FRET changes in cancer cells expressing MT1-MMP, but not in MT1-MMP-deficient cells. EGF-induced FRET changes in MT1-MMP-deficient cells could be restored after reconstituting with wild-type MT1-MMP, but not MMP-2, MMP-9, or inactive MT1-MMP mutants. Deletion of the transmembrane domain in the biosensor or treatment with tissue inhibitor of metalloproteinase-2, a cell-impermeable MT1-MMP inhibitor, abolished the EGF-induced FRET response, indicating that MT1-MMP acts at the cell surface to generate FRET changes. In response to EGF, active MT1-MMP was directed to the leading edge of migrating cells along micropatterned fibronectin stripes, in tandem with the local accumulation of the EGF receptor, via a process dependent upon an intact cytoskeletal network. Hence, the MT1-MMP biosensor provides a powerful tool for characterizing the molecular processes underlying the spatiotemporal regulation of this critical class of enzymes.
Data from First-in-Human Phase I/II ICONIC Trial of the ICOS Agonist Vopratelimab Alone and with Nivolumab: ICOS-High CD4 T-Cell Populations and Predictors of Response (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;The first-in-human phase I/II ICONIC trial evaluated an investigational inducible costimulator (ICOS) agonist, vopratelimab, alone and in combination with nivolumab in patients with advanced solid tumors.&lt;/p&gt;Patients and Methods:&lt;p&gt;In phase I, patients were treated with escalating doses of intravenous vopratelimab alone or with nivolumab. Primary objectives were safety, tolerability, MTD, and recommended phase II dose (RP2D). Phase II enriched for ICOS-positive (ICOS+) tumors; patients were treated with vopratelimab at the monotherapy RP2D alone or with nivolumab. Pharmacokinetics, pharmacodynamics, and predictive biomarkers of response to vopratelimab were assessed.&lt;/p&gt;Results:&lt;p&gt;ICONIC enrolled 201 patients. Vopratelimab alone and with nivolumab was well tolerated; phase I established 0.3 mg/kg every 3 weeks as the vopratelimab RP2D. Vopratelimab resulted in modest objective response rates of 1.4% and with nivolumab of 2.3%. The prospective selection for ICOS+ tumors did not enrich for responses. A vopratelimab-specific peripheral blood pharmacodynamic biomarker, ICOS-high (ICOS-hi) CD4 T cells, was identified in a subset of patients who demonstrated greater clinical benefit versus those with no emergence of these cells [overall survival (OS), &lt;i&gt;P&lt;/i&gt; = 0.0025]. A potential genomic predictive biomarker of ICOS-hi CD4 T-cell emergence was identified that demonstrated improvement in clinical outcomes, including OS (&lt;i&gt;P&lt;/i&gt; = 0.0062).&lt;/p&gt;Conclusions:&lt;p&gt;Vopratelimab demonstrated a favorable safety profile alone and in combination with nivolumab. Efficacy was observed only in a subset of patients with a vopratelimab-specific pharmacodynamic biomarker. A potential predictive biomarker of response was identified, which is being prospectively evaluated in a randomized phase II non–small cell lung cancer trial.&lt;/p&gt;&lt;p&gt;&lt;i&gt;&lt;a href="https://aacrjournals.org/clincancerres/article/doi/10.1158/1078-0432.CCR-22-1520" target="_blank"&gt;See related commentary by Lee and Fong, p. 3633&lt;/a&gt;&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Parallel computation method for large metal-only reflectarray (MOR) antennas (2016)

A parallel computation method for a large metal-only reflectarray (MOR) antenna is proposed with OpenMP, MPI, and CUDA. An overlapping T-block method with a mode-matching technique and a Green's function method is applied to the large MOR structure, and then the method is decomposed suitable for OpenMP, MPI, and CUDA. We implemented 18 compute nodes with 8-core CPU and 1,536-core GPU. Speedup ratio compared with the CST Microwave Studio is 2,388.
Filtration of Cigarette Smoke: Relative Contributions of Inertial Impaction, Diffusional Deposition, and Direct Interception (1973)

Abstract The results of this analysis suggest that a filter geometry which will allow smoke to pass at a Iower than normal velocity is desirable to improve filter efficiency. This improved efficiency is due to the major contribution of the diffusion mechanism and the insignificant contribution of the impaction mechanism to the filtration process. Lower than normal velocities wilI also reduce the pressure drop. If a filter can be designed to operate at a lower velocity, and therefore at a lower pressure drop, it is desirable to have the acetate filaments oriented perpendicularly to the flow direction of the smoke. This geometry gives higher removal per unit weight of acetate than the geometry of a conventional filter.
Cathepsin D-mediated processing of procollagen: lysosomal enzyme involvement in secretory processing of procollagen. (1984)

The proteolytic removal of the extension COOH-terminal propeptide from procollagen has been examined in vitro. A crude enzyme activity was identified in a whole-chicken-embryo extract that acted at acid pH and appeared to be similar to one identified previously [Davidson, J. M., McEneany , L. S. G. & Bornstein , P. (1979) Eur. J. Biochem. 100, 551-558]. This activity was inhibitable by pepstatin but not by leupeptin, suggesting that it might be cathepsin D. Cathepsin D was purified 907-fold from chicken livers by affinity chromatography on pepstatin-aminohexyl-Sepharose 4B and was found to remove the COOH propeptides from procollagen. At pH 6.0, the site of cleavage appeared to shift from the COOH telopeptide to the COOH telopeptide/propeptide junction, based upon the difference in electrophoretic migration of the cleavage products, although determining the actual cleavage site will require end-group analysis. A model for the involvement of cathepsin D in the in vivo processing of procollagen is presented.
Contact-Dependent Protein Secretion in Porphyromonas gingivalis (1998)

Porphyromonas gingivalis can induce its uptake by host epithelial cells; however, the nature and role of the P. gingivalis molecules involved in this invasion process have yet to be determined. In this study, modulation of secreted P. gingivalis proteins following association with gingival epithelial cells was investigated. Western immunoblot analysis showed that contact with epithelial cells or epithelial cell growth media induces P. gingivalis 33277 to secrete several proteins with molecular masses between 35 and 95 kDa. Secretion of the Arg-gingipain and Lys-gingipain proteases was repressed under these conditions. The contact-induced secreted protein profile was altered in Arg-gingipain-deficient and Lys-gingipain-deficient mutants, indicating a possible role for these proteases in the secretion pathway. The P. gingivalis contact-dependent protein secretion pathway differs to some extent from type III protein secretion pathways in enteric pathogens, as a gene homologous to the invA family genes was not detected in P. gingivalis. The secreted proteins of P. gingivalis may play a role in the interactions of the organism with host cells.
Regulation von Immunsystem und Allergien. Retinoide, Vitamin A und Pro‐Vitamin‐A‐Carotinoide (2009)

Abstract Vitamin A und Pro‐Vitamin‐A‐Carotinoide sind in hohen Konzentrationen in der westlichen Ernährung enthalten. Eine humane Vitamin‐A‐Defizienz kommt in westlichen Ländern daher extrem selten vor. Eine Überversorgung mit Vitamin A tritt jedoch häufig auf und kann möglicherweise ein wesentlicher Faktor bei der gesteigerten Prävalenz von atopischen Erkrankungen in westlichen Ländern sein. Dabei spielt der Einfluss von Vitamin A auf das Immunsystem eine mögliche entscheidende Rolle. Retinsäuren, die haupt‐aktiven Derivate des Vitamin A, sind spezifische und selektive Aktivatoren von nukleären Hormon‐Rezeptoren und sind somit wichtige nahrungsrelevante Metaboliten für das Immunsystem. Die Regulation spezifischer Immunantworten auf Allergien ist in einem großen Maße abhängig von Retinoiden. Konzentrationen von Vitamin A und Pro‐Vitamin‐A‐Carotinoiden in unserer Nahrung, und somit später im Körper, können spezifische Immunfunktionen sowohl positiv als auch negativ beeinflussen.
Requirements for compatibility between local and multipartite quantum\n states (2003)

We consider a partial trace transformation which maps a multipartite quantum\nstate to collection of local density matrices. We call this collection a mean\nfield state. The necessary and sufficient conditions under which a mean field\nstate is compatible with at least one multipartite pure state are found for the\nsystem of $n$ qubits and for the tripartite system with the Hilbert space of\ndimension 2x2x4. Compatibility of mean field states with more general classes\nof multipartite quantum states is discussed.\n
Synthesis of polymeric tetraphenylphosphonium (tetraselenido)argentate(1-) [(Ph4P)AgSe4]n. A novel one-dimensional inorganic polymer (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of polymeric tetraphenylphosphonium (tetraselenido)argentate(1-) [(Ph4P)AgSe4]n. A novel one-dimensional inorganic polymerMercouri G. Kanatzidis and Song Ping HuangCite this: J. Am. Chem. Soc. 1989, 111, 2, 760–761Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/ja00184a070https://doi.org/10.1021/ja00184a070research-articleACS PublicationsRequest reuse permissionsArticle Views125Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Westerbork ultra-deep HI imaging of galaxy clusters at z=0.2 (2010)

We report here on results from our completed ultra-deep blind HI survey of two galaxy clusters at redshift z=0.2, performed with the Westerbork Synthesis Radio Telescope. The field of the X-ray bright, massive Butcher-Oemler cluster Abell 963 was observed with a total of 117x12hrs integration time. Additionally, Abell 2192 was observed as an example of a more diffuse cluster, at similar distance, with a total of 73x12hrs integration time. In both fields, sampling a total volume of 7x10 4 Mpc 3 , the expected noise levels of 19 and 24 Jy/beam respectively, at a velocity resolution of 44km/s, were achieved. These HI measurements are part of a multi-wavelength survey including ultraviolet(GALEX), optical(INT), infrared(Spitzer), and rest frame 1.4 GHz radio-continuum data(WSRT).The goal is to study the gas content of galaxies in various environments at a redshift of 0.2 and in particular the gas content of the blue galaxies that are responsible for the Butcher-Oemler effect in Abell 963.
Computing the modulation transfer function of a magnetic resonance imager (1994)

A new method for computing the modulation transfer function (MTF) of magnetic resonance (MR) imagers is presented. Previous attempts to compute the MTF of MR imagers used nonlinear magnitude reconstructed images, resulting in erroneous MTFs. By using complex domain images, the new method produces predisplay MTFs which describe the spatial frequency transfer characteristics of the entire image formation process, except the magnitude operator, eliminating the artifacts previously found in MR imager MTFs. The use of complex domain images results in two‐sided MTFs which differentiate the positive and negative frequencies associated with positive and negative phase encoding or positive and negative time relative to the echo formation. Experimental results are presented which confirm the theoretically predicted form of MR imager MTFs and the need for two‐sided MTFs.
Quantum Particle Swarm Optimization for Electromagnetics (2007)

A new particle swarm optimization (PSO) technique for electromagnetic applications is proposed. The method is based on quantum mechanics rather than the Newtonian rules assumed in all previous versions of PSO, which we refer to as classical PSO. A general procedure is suggested to derive many different versions of the quantum PSO algorithm (QPSO). The QPSO is applied first to linear array antenna synthesis, which is one of the standard problems used by antenna engineers. The performance of the QPSO is compared against an improved version of the classical PSO. The new algorithm outperforms the classical one most of the time in convergence speed and achieves better levels for the cost function. As another application, the algorithm is used to find a set of infinitesimal dipoles that produces the same near and far fields of a circular dielectric resonator antenna (DRA). In addition, the QPSO method is employed to find an equivalent circuit model for the DRA that can be used to predict some interesting parameters like the Q-factor. The QPSO contains only one control parameter that can be tuned easily by trial and error or by suggested simple linear variation. Based on our understanding of the physical background of the method, various explanations of the theoretical aspects of the algorithm are presented.
Sleep/Wake Physiology and Quantitative Electroencephalogram Analysis of the Neuroligin-3 Knockout Rat Model of Autism Spectrum Disorder (2017)

The sleep disruptions in Nlgn3 KO rats are consistent with observations of sleep disturbances in ASD patients. The EEG provides objective measures of brain function to complement rodent behavioral analyses and therefore may be a useful tool to study ASD.
The authors reply (2022)

Azimaraghi, Omid MD; Wongtangman, Karuna MD; Eikermann, Matthias MD, PhD Author Information
Early period of fracture healing in ovariectomized rats. (2003)

Osteoporosis influences the quantity and quality of callus during the early period of fracture healing. The effect of osteoporosis on fracture healing has no relationship with the expression of BMP-2 or bFGF. The decreased expression of TGF-beta1 in osteoblasts may cause a decrease in quality of fracture healing after osteoporosis.
Genome annotation of Caenorhabditis briggsae by TEC-RED identifies new exons, paralogs, and conserved and novel operons (2022)

The nematode Caenorhabditis briggsae is routinely used in comparative and evolutionary studies involving its well-known cousin Caenorhabditis elegans. The C. briggsae genome sequence has accelerated research by facilitating the generation of new resources, tools, and functional studies of genes. While substantial progress has been made in predicting genes and start sites, experimental evidence is still lacking in many cases. Here, we report an improved annotation of the C. briggsae genome using the trans-spliced exon coupled RNA end determination technique. In addition to identifying the 5' ends of expressed genes, we have discovered operons and paralogs. In summary, our analysis yielded 10,243 unique 5' end sequence tags with matches in the C. briggsae genome. Of these, 6,395 were found to represent 4,252 unique genes along with 362 paralogs and 52 previously unknown exons. These genes included 14 that are exclusively trans-spliced in C. briggsae when compared with C. elegans orthologs. A major contribution of this study is the identification of 492 high confidence operons, of which two-thirds are fully supported by tags. In addition, 2 SL1-type operons were discovered. Interestingly, comparisons with C. elegans showed that only 40% of operons are conserved. Of the remaining operons, 73 are novel, including 12 that entirely lack orthologs in C. elegans. Further analysis revealed that 4 of the 12 novel operons are conserved in Caenorhabditis nigoni. Altogether, the work described here has significantly advanced our understanding of the C. briggsae system and serves as a rich resource to aid biological studies involving this species.
[Drug discovery based on the research on orphan receptor/ligand]. (2002)

The present world-wide leading products are mostly receptor antagonists and agonists and enzyme inhibitors when classified by the mechanism of action. We consider there will be less possibilities of taking the initiative in successful finding of a target for an innovative drug winning a worldwide contest only by taking up known receptors and enzymes. Therefore, we have used the results of current genetic researches to utilize orphan G-protein-coupled receptors (GPERs) whose ligands are not known yet as targets for drug discovery, and have conducted various examinations about how to implement it. The results obtained here can be combined with the conventional methods for drug discovery. Hence, this technology is considered to be the main stream of future drug discovery research.
Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach (2021)

<b>Background:</b> Ageing and chronic kidney disease (CKD) affect pharmacokinetic (PK) parameters. Since mechanisms are related and remain unclear, cytochrome P450 (CYP) 3A and drug transporter activities were investigated in the elderly with or without CKD and compared to healthy adults using a microdose cocktail. <b>Methods:</b> Healthy young participants (<i>n</i> = 20), healthy elderly participants (<i>n</i> = 16) and elderly patients with CKD (<i>n</i> = 17) received, in study period 1, a single dose of microdose cocktail probe containing 30 µg midazolam, 750 µg dabigatran etexilate, 100 µg atorvastatin, 10 µg pitavastatin, and 50 µg rosuvastatin. After a 14-day wash-out period, healthy young participants continued to study period 2 with the microdose cocktail plus rifampicin. PK parameters including area under the plasma concentration-time curve (AUC), maximum plasma drug concentration (C<sub>max</sub>), and half-life were estimated before making pairwise comparisons of geometric mean ratios (GMR) between groups. <b>Results:</b> AUC and C<sub>max</sub> GMR (95% confidence interval; CI) of midazolam, a CYP3A probe substrate, were increased 2.30 (1.70-3.09) and 2.90 (2.16-3.88) fold in healthy elderly and elderly patients with CKD, respectively, together with a prolonged half-life. AUC and C<sub>max</sub> GMR (95%CI) of atorvastatin, another CYP3A substrate, was increased 2.14 (1.52-3.02) fold in healthy elderly and 4.15 (2.98-5.79) fold in elderly patients with CKD, indicating decreased CYP3A activity related to ageing. Associated AUC changes in the probe drug whose activity could be modified by intestinal P-glycoprotein (P-gp) activity, dabigatran etexilate, were observed in patients with CKD. However, whether the activity of pitavastatin and rosuvastatin is modified by organic anion transporting polypeptide 1B (OATP1B) and of breast cancer resistance protein (BCRP), respectively, in elderly participants with or without CKD was inconclusive. <b>Conclusions:</b> CYP3A activity is reduced in ageing. Intestinal P-gp function might be affected by CKD, but further confirmation appears warranted. <b>Clinical Trial Registration:</b>http://www.thaiclinicaltrials.org/ (TCTR 20180312002 registered on March 07, 2018).