gebhart/patrepeval huggingface dataset:
High Circulating Leptin Receptors with Normal Leptin Sensitivity in Liver-specific Insulin Receptor Knock-out (LIRKO) Mice (2007)

Liver-specific insulin receptor knock-out (LIRKO) mice display hyperinsulinemia, abnormal glucose metabolism, and progressive liver dysfunction. In addition, circulating leptin levels appear to be increased more than 10-fold. However, food intake, body weight, and adipose mass are not significantly altered in LIRKO mice compared with wild-type littermates. Using a ligand immunofunctional assay, we found that the apparent increase in circulating leptin in LIRKO mice is because of an 80-fold increased serum level of soluble leptin receptor. Gene expression analysis by microarray and real time PCR reveals the liver as the source of soluble leptin receptor in LIRKO mice, with an increase in expression of the short (Ob-Ra), long (Ob-Rb), and soluble (Ob-Re) forms of the leptin receptor. Direct control of leptin receptor expression by insulin could also be demonstrated in isolated hepatocytes from normal mice. Despite the markedly increased levels of leptin receptor in their circulation, LIRKO mice exhibit normal or even enhanced leptin sensitivity, as assessed by their physiological and molecular responses to exogenous leptin administration and their lower base-line hypothalamic levels of SOCS3 mRNA. Thus, insulin signaling in the liver plays an important role in control of leptin receptor expression and shedding. In the LIRKO mouse, this is lost, leading to markedly increased leptin receptors into the circulation. These high levels of circulating leptin receptor bind leptin and likely alter its clearance, but do not inhibit leptin action and may actually potentiate leptin action. In this manner, insulin signaling in liver plays an important role in leptin homeostasis and fine modulation of leptin action.
Physiologic action of glucagon on liver glucose metabolism (2011)

Glucagon is a primary regulator of hepatic glucose production (HGP) in vivo during fasting, exercise and hypoglycaemia. Glucagon also plays a role in limiting hepatic glucose uptake and producing the hyperglycaemic phenotype associated with insulin deficiency and insulin resistance. In response to a physiological rise in glucagon, HGP is rapidly stimulated. This increase in HGP is entirely attributable to an enhancement of glycogenolysis, with little to no acute effect on gluconeogenesis. This dramatic rise in glycogenolysis in response to hyperglucagonemia wanes with time. A component of this waning effect is known to be independent of hyperglycemia, though the molecular basis for this tachyphylaxis is not fully understood. In the overnight fasted state, the presence of basal glucagon secretion is essential in countering the suppressive effects of basal insulin, resulting in the maintenance of appropriate levels of glycogenolysis, fasting HGP and blood glucose. The enhancement of glycogenolysis in response to elevated glucagon is critical in the life-preserving counterregulatory response to hypoglycaemia, as well as a key factor in providing adequate circulating glucose for working muscle during exercise. Finally, glucagon has a key role in promoting the catabolic consequences associated with states of deficient insulin action, which supports the therapeutic potential in developing glucagon receptor antagonists or inhibitors of glucagon secretion.
Rapid, amplification-based fingerprinting of Mycobacterium tuberculosis (1993)

Insertion element IS6110 occurs in multiple copies throughout the Mycobacterium tuberculosis genome, and the variability of its insertion sites is the basis for the IS6110 restriction fragment length polymorphism (RFLP) method for typing. We describe a novel gene amplification method to assess the variability of the location of IS6110. A unilateral-nested polymerase chain reaction and hybridization procedure was used to measure the variability in the distances between IS6110 elements and copies of a major polymorphic tandem repeat sequence of M. tuberculosis. The pattern of amplicons produced could be used to cluster epidemiologically related strains of M. tuberculosis into groups which correlated with the groups formed using IS6110-RFLP typing. Reliable patterns can be generated directly from sputum specimens as well as from M. tuberculosis cultures. We designated the novel method as IS6110-ampliprinting.
Quantitative in vivo mapping of myocardial mitochondrial membrane potential (2018)

We have analyzed the factors affecting the uptake of voltage sensing tracers and developed a minimally invasive method for mapping ΔΨT in left ventricular myocardium of pigs. ΔΨT is computed in absolute units, allowing for visual and statistical comparison of individual values with normative data. These studies demonstrate the first in vivo application of quantitative mapping of total tissue membrane potential, ΔΨT.
Review of equipment aging theory and technology. Final report (1980)

The theory and technology of equipment aging is reviewed, particularly as they relate to the qualification of safety-system equipment for nuclear power generating stations. A fundamental degradation model is developed, and its relation to more restricted models (e.g., Arrhenius and inverse-stress models) is shown. The most common theoretical and empirical models of aging are introduced, and limitations on their practical application are analyzed. Reliability theory and its application to the acceleration of aging are also discussed. A compendium of aging data for materials and components, including degradation mechanisms, failure modes and activation energies, is included.
Stacked bed hydrotreating catalyst technology (1986)

A process for treating heavy oils under conditions which normally results in excessive coking deactivation of the catalyst has been developed by Shell. The process consists, in part, of passing the oil mixture over a stacked bed of hydrotreating catalysts. Through the use of two catalysts in portions of the reactor where each performs best, a synergystic effect is obtained. Catalyst cycle lives of the order of 1.5 to 3 times that of the individual catalyst in the same service have been observed. The better performance of the stacked bed system can be used to increase run length, the extent of the upgrading and/or the heaviness of the oil processed. The process has been demonstrated in several commercial applications.
Preparation of Transparent TiO2 Thin Film Photocatalyst and Its Photocatalytic Activity (1995)

Abstract Transparent TiO2 thin films with high photocatalytic activity were prepared on glass substrates via the sol-gel method from tetraisopropyl titanium ethanol solution containing polyethylene glycol and diethylene glycol. Transparency of these TiO2 thin films was 80% in the visible region. Photocatalytic activity of the TiO2 thin films was studied using the decomposition of gaseous acetaldehyde. We found that the quantum yield with those films was similar to that with one of the most photoactive commercial TiO2 powders, Degussa P-25.
Membrane techniques for analysis, sampling and speciation in environmental measurements (2003)

Abstract is not available
Optimization of enhanced absorption in  3D-woodpile metallic photonic crystals (2010)

We present a detailed theoretical analysis which reveals a useful insight to understand the resonant dissipative behavior of 3D woodpile metallic photonic crystals in the spectral response. We observe that a small amount of structural parameter modifications can induce great flexibility to alter the properties of the absorption resonance with even an extremely narrow band width of ~13 nm. Analyzing the dispersive properties of the 3D woodpile metallic photonic crystals and performing thorough numerical simulations for the finite number of layers we found that the magnitude, band width, and tunability of enhanced absorption can be easily optimized, which can be of significance to design an efficient photonic crystal thermal emitter.
Development of large-capacity main steam isolation valves and safety relief valves for next-generation BWR plant (2002)

A study was made of high capacity main steam isolation valves (MSIV) and safety relief valves (SRV) for the main steam line of a boiling water reactor (BWR). The next-generation BWR plants, which are planned to have higher thermal power, have raised concerns relating to the main steam line of an increase in maintenance work to SRVs and erosion of the MSIV valve seat due to the increased main steam flow velocity. In this research project, the capacity of the MSIV and SRV was increased and the valve configuration was changed in an attempt to solve these problems. (authors)
Supplementary Files 1-11 from Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies (2023)

&lt;p&gt;A file containing RPPA and RNAseq datasets, pathway analyses and prediction calculations presented in the main figures.&lt;/p&gt;
Minimum augmentation of a tree to a K‐edge‐connected graph (1988)

Abstract This paper solves the minimum augmentation problem for a given tree and positive integer k, that is, to make a tree k‐edge‐connected by adding the minimum number of edges. It is shown that the minimum number of edges is the least integer not less than a half of the deficiency of the tree which is defined as the sum of k‐(degree) over all the vertices whose degrees are less than k. The proof is constructive and gives a polynomial‐time algorithm for constructing such an augmentation.
Preoperative Circulating Succinate Levels as a Biomarker for Diabetes Remission After Bariatric Surgery (2019)

Circulating succinate is reduced after bariatric surgery. Baseline succinate levels have predictive value for diabetes remission independently of previously described presurgical factors and improve upon the current available scores to predict remission.
Potential Thrombogenic Complications With the Use of Recombinant Activated Factor VII in Combat Trauma (2007)

by many medical experts for expanded usage in the management of medical, surgical, and traumaassociated bleeding in hospitalized patients. There is no question that NovoSeven administration has been associated with numerous miraculous saves; however, there also is a dearth of well-controlled clinical trials that could provide insight into what criteria should be applied to maximize its safe use in the context of its known potential thrombogenicity. More recently the Israeli and US armies have used NovoSeven for the control of bleeding occurring with battlefield and combat trauma. The US Army has developed and posted guidelines for the use of recombinant FVIIa in military hospitals. Although this use of NovoSeven is off-label and nonstandardized, the Army is to be commended for exploring its use in the management of bleeding in battlefield conditions where the conventional methods have not always been effective. A recent article, “Dangerous Remedy. Military doctors in Iraq say that factor VIIa saves wounded soldiers, but other doctors and medical research suggest that it can cause fatal clots” (Baltimore Sun, November 19, 2006) authored by Robert Little, a Sun reporter, has provided a comprehensive review of the adverse thrombogenic complications associated with the use of NovoSeven. This article reported that the US Amy has injected more than 1000 trauma-inflicted soldiers with NovoSeven. The Baltimore Sun article is based on the extensive battlefield observations and research conducted by the reporter. Moreover, the reporter also interviewed several experts in the field of hemostasis and Recombinant activated factor VII (FVIIa; NovoSeven, Novo Nordisk, Copenhagen) was approved by the United States (US) Food and Drug Administration (FDA) in March 1999 for the alternate hemostatic management of hemophilia patients who develop antibodies to FVIII. Although medically useful, there have been reports of adverse thrombogenic complications associated with its use. In an article published in the Journal of the American Medical Association in December 2005, the FDA cautioned that the administration of NovoSeven for heretofore unlicensed indications to healthy, nonhemophilic individuals could result in complications such as stroke and myocardial infarction, possibly leading to death. Almost all of these clotting complications were detected in older individuals administered NovoSeven to reverse bleeding not related to hemophilia. Clotting complications rarely have occurred in the much younger individuals with hemophilia-related antibodies who have received NovoSeven to treat or prevent active bleeding. Because anecdotal reports have provided the impression that life-threatening and overwhelming bleeding complications in desperate situations could be treated successfully and rapidly with NovoSeven administration, the use of this genetically Editorial
Dietitians’ Role in Critical Care Interdisciplinary Team Needs Better Recognition (2022)

Sriram, Krishnan MBBS, FCCM, FRCS(C); Cresci, Gail A. M. PhD, RD, LD Author Information
HOW TO (REALLY) SHARE A 8ECRZT1 (1990)

In information based systems, the integrity of the information (from unauthorized scrutiny or disclosure, manipulation or alteration, forgery, false dating, etc.) is commonly provided for by requiring operation(s) on the information that one or more of the participants, who know some private piece(s) of information not known to all of the other participants, can carry out but which (probably) can't be carried out by anyone who doesn't know the private information. Encryption/decryption in a single key cryptoalgorithm is a paradigm of such an operation, with the key being the private (secret) piece of information. Although it is implicit, it is almost never stated explicitly that in a single-key cryptographic communications link, the transmitter and the receiver must unconditionally trust each other since either can do anything that the other can.
Marker chromosome is a strong poor prognosis factor after allogeneic HSCT for adverse‐risk AML patients (2020)

Our study suggests MC as a new independent factor for chromosome risk classification to further classify AD-AML.
Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity (2008)

At synapses between cortical pyramidal neurons and principal striatal medium spiny neurons (MSNs), postsynaptic D1 and D2 dopamine (DA) receptors are postulated to be necessary for the induction of long-term potentiation and depression, respectively-forms of plasticity thought to underlie associative learning. Because these receptors are restricted to two distinct MSN populations, this postulate demands that synaptic plasticity be unidirectional in each cell type. Using brain slices from DA receptor transgenic mice, we show that this is not the case. Rather, DA plays complementary roles in these two types of MSN to ensure that synaptic plasticity is bidirectional and Hebbian. In models of Parkinson's disease, this system is thrown out of balance, leading to unidirectional changes in plasticity that could underlie network pathology and symptoms.
A unified optimization framework for simultaneous gate sizing and placement under density constraints (2011)

A unified optimization framework is presented for simultaneous gate sizing and placement. These processes are unified using Lagrangian multipliers, which synchronize the efforts of the gate sizing and placement subproblems. As far as we know, this is the first work that formulates and solves the simultaneous gate sizing and placement under area density constraints, which are handled by the quadratic penalty method. We show that this rigorous framework results in an algorithm that is faster than separate iterations of gate sizing and placement steps, and leads to more robust results for a set of benchmarks.
A Fast and Activatable Cross‐Linking Strategy for Hydrogel Formation (2014)

Strain-promoted oxidation-controlled cyclo-octyne-1,2-quinone cycloaddition (SPOCQ) is a fast and activatable cross-linking strategy for hydrogel formation. Gelation is induced by oxidation, which is performed both chemically using sodium periodate and enzymatically using mushroom tyrosinase. Due to the fast reaction kinetics, SPOCQ-formed hydrogels can be functionalized in one-pot with an azido-containing moiety using SPAAC cross-linking.
Structure of PduT, a trimeric bacterial microcompartment protein with a 4Fe–4S cluster-binding site (2011)

Propanediol metabolism in Citrobacter freundii occurs within a metabolosome, a subcellular proteinaceous bacterial microcompartment. The propanediol-utilization (Pdu) microcompartment shell is constructed from thousands of hexagonal-shaped protein complexes made from seven different types of protein subunit. Here, the structure of the bacterial microcompartment protein PduT, which has a tandem structural repeat within the subunit and forms trimers with pseudo-hexagonal symmetry, is reported. This trimeric assembly forms a flat approximately hexagonally shaped disc with a central pore that is suitable for a 4Fe-4S cluster. The essentially cubic shaped 4Fe-4S cluster conforms to the threefold symmetry of the trimer with one free iron, the role of which could be to supply electrons to an associated microcompartment enzyme, PduS.
Remodeling ofECMpatch into functional myocardium in an ovine model: A pilot study (2015)

At 5 and 8 months, the ECM had undergone extracellular matrix remodeling and neovascularization without calcification. The ECM was populated with locally aligned muscle cells positive for sarcomeric alpha-actinin, CD45, and troponin I and T. In sheep, the ECM patch appears to have the potential of remodeling to resemble native, functional ventricular tissue as evidenced by histological, mechanical, and electrical properties. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1713-1720, 2016.
Excellent Aldehyde and Ketone Selectivity in Chromium(II)-Mediated Reformatsky Reactions (1997)

The chromium Reformatsky reaction allows the highly chemoselective addition of ester enolates to aldehydes or methyl ketones at room temperature. Aldehyde selectivities of ≥ 50:1 vs. methyl ketones and ≥ 200:1 vs. larger ketones and other electrophiles can be achieved in most cases. Methyl ketones are preferred with similar effectivity against higher ketones. Effects of solvents, lithium iodide and substituents are discussed.
High quality ultrathin Bi2Se3 films on CaF2 and CaF2/Si by molecular beam epitaxy with a radio frequency cracker cell (2012)

We report a method to fabricate high quality Bi2Se3 thin films using molecular beam epitaxy with a radio frequency cracker cell as an atomic selenium source. With Se-to-Bi ratios close to exact stoichiometry, optimal layer-by-layer growth of high quality Bi2Se3 thin films with smooth surfaces has been achieved on CaF2(111) substrates and Si(111) substrates with a thin epitaxial CaF2 buffer layer (CaF2/Si). Transport measurements show a characteristic weak-antilocalization magnetoresistance in all the films, with the emergence of a weak-localization contribution in the ultrathin film limit. Quantum oscillations, attributed to the topological surface states have been observed, including in films grown on CaF2/Si.
Aviation Science? Collegiate Aviation? Aeronautics? Aerospace Science? Introducing Aeronology in Resolving Identity Issues (1997)

In asking collegiate aviation educators for a term or a phrase that adequately describes their academic field, it does not take much time to discover that widespread agreement is notably absent. If we as aviation educators are unable to collectively identify ourselves and the niche we inhabit in the realm of the entire academic community, then how much more difficult will it be for the remainder of the academic community and the general public to identify us as well? There are three possible solutions for aviation educators to consider in confronting the identity problem. Educators can: (1) conclude that identity is really not a problem, (2) identify a term/phrase by consensus to describe the aviation field, or (3) create a new word.
Pedestal collector optimization for high speed SiGe:C HBT (2011)

An optimized collector doping profile for high-speed SiGe:C HBT devices is presented. A thin and abrupt collector pedestal is implemented in a f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> /f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MAX</sub> 245GHz/460GHz fully self-aligned HBT architecture.
Circulating HMGB1 is increased in myelodysplastic syndrome but not in other bone marrow failure syndromes: proof-of-concept cross-sectional study (2022)

These observations indicate that circulating HMGB1 is increased in patients with MDS. HMGB1 (but not IL-1β or TNF-α) differentiated between MDS and other BM failures, suggesting that HMGB1 may be mechanistically involved in MDS and a druggable target to decrease inflammation in MDS.
Association between Depression, Lifestyles, Sleep Quality, and Sense of Coherence in a Population with Cardiovascular Risk (2021)

People with cardiovascular risk have more depression than the general population. Depression and cardiovascular risk have been commonly linked to lower sense of coherence (SOC) values, unhealthy lifestyles, and poor sleep quality. The aim of this study was to analyze the association between depression, health-related lifestyles, sleep quality, and SOC in a population with cardiovascular risk. A cross-sectional study was conducted in 310 participants (aged 35-75 years) with cardiovascular risk. Sociodemographic and anthropometric characteristics, cardiovascular risk, SOC score, depression levels, sleep quality, and lifestyles (physical activity, diet quality (measured as the adherence to the Mediterranean diet), and tobacco and alcohol consumption) were determined. The regression analysis showed significant associations between depression levels and sex (odds ratio (OR): 2.29; 95% CI: 1.29, 4.07), diet (OR: 0.85; 95% CI: 0.73, 0.99), body mass index (BMI) (OR: 1.06; 95% CI: 1.01, 1.12), cardiovascular disease (CVD) (OR: 2.55; 95% CI: 1.18, 5.48), sleep quality (OR: 0.26; 95% CI: 0.15, 0.46), and SOC (OR: 0.96; 95% CI: 0.94, 0.98). Protective effects of male sex, a lower BMI, no CVD, a higher adherence to the Mediterranean diet, a high sleep quality, and a higher SOC were found. In conclusion, among lifestyles determined, only diet was associated with depression levels. SOC and sleep quality were also found as significant predictors for depression levels.
Operation of reconfigurable mobile device for spectrum sharing (2015)

In order for a mobile device to efficiently support the spectrum sharing, the mobile device shall be reconfigurable, meaning that its radio application code has to be adaptively changed in accordance with the hopping of desired spectral band. Based on the standard architecture defined in Working Group (WG)2 of Technical Committee (TC) - Reconfigurable Radio System (RRS) of European Telecommunications Standards Institute (ETSI), this paper presents related procedures among the software entities of the reconfigurable mobile device required for implementing the spectrum sharing. In this paper, we consider the scenario of the spectrum sharing that has been demonstrated in WG1 of TC-RRS of ETSI. The related parameters such as center frequency, modulation scheme, etc considered in this paper are also based on what have been presented by the WG1 of TC-RRS. This paper also addresses the interactions among the standard software entities of the reconfigurable mobile device and required interfaces services.