gebhart/patrepeval huggingface dataset:
Real-time target localization and tracking by N-ocular stereo (2002)

In recent years, various practical systems using multiple vision sensors have been proposed. In this paper, as an application of such vision systems, we propose a real-time human tracking system consisting of multiple omnidirectional vision sensors (ODVSs). The system measures people's locations by N-ocular stereo, which is an extension of trinocular stereo, from omnidirectional images taken with the ODVSs. In addition, the system employs several compensation methods for observation errors in order to achieve robust measurement. We have evaluated the proposed methods in the experimentation using four compact ODVSs we have originally developed.
Computational motor control (2004)

Unifying principles of movement have emerged from the computational study of motor control. We review several of these principles and show how they apply to processes such as motor planning, control, estimation, prediction and learning. Our goal is to demonstrate how specific models emerging from the computational approach provide a theoretical framework for movement neuroscience.
Fermented Carica papaya and Morinda citrifolia as Perspective Food Supplements for the Treatment of Post-COVID Symptoms: Randomized Placebo-Controlled Clinical Laboratory Study (2022)

Food supplements based on fermented <i>Carica papaya</i> and <i>Morinda citrifolia</i>, known for their immune modulating, redox balancing, and anti-inflammatory effects, were added to conventional treatment protocols prescribed to patients recovering after severe and moderate COVID-19 disease in order to alleviate long-lasting post-COVID symptoms. A randomized single-center placebo-controlled clinical laboratory study was designed and performed (total number of participants 188, with delta variant of virus 157, with omicron 31). Clinical statuses were assessed using computer tomography, electrocardiography, a questionnaire, and physical endurance. Plasma cytokines (IL-6, IL-8, IL-17A, and INF-gamma), nitrate/nitrite ratio, antioxidant activity (AOA), and polymorphonuclear leukocyte (PMN) ATP levels were determined before and 20 days following the addition of 28 g of fermented supplements twice per day. The capacity of PMN to phagocyte and the oral-nasal-pharyngeal microbiota were assessed. Clinical symptoms, IL-6, IL-8, and nitric oxide metabolites diminished significantly compared to the placebo group and their background expression. The PMN capacity to phagocyte, AOA, and ATP content remarkably increased. The oral-nasal-pharyngeal microbiota were unchanged. On these grounds, we suggest that fermented tropical fruits could efficiently diminish post-COVID clinical symptoms through several immune-modulating, redox balancing, and pro-energy mechanisms.
A comparison of the cutaneous microvascular properties of the Spontaneously Hypertensive and the Wistar-Kyoto rats by Spectral analysis of Laser Doppler (2018)

This work was aimed to study skin blood perfusion, vasomotion and vascular responses of the Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) in different stages of age using spectral. Laser-Doppler flowmetry (LDF) was used to examine the ears and limbs of WKY (12 and 48 weeks old) and SHR (12 and 48 weeks old). The skin blood flow oscillations (SBFOs) were studied by wavelet spectral analysis of LDF tracings. Then, we observed that old groups showed decreased perfusion and SBFO in the ears of both SHR and WKY. The SHR showed obviously lower postocclusive reactive hypera (PORH) ratio at the same age. A decreased peak-time occurred in the SHR of old age group. After PORH test, a statistically significant increase was observed within all subintervals in the absolute amplitude of 12-week WKY and only within IV and III subintervals in the absolute amplitude of 12-week SHR. But, the absolute amplitude of 48-week WKY and SHR showed no statistically significant increase within all subintervals. Results indicated that local regulating function of peripheral vascular was impaired in rat with hypertension and aging. Abbreviations LDF: Laser-Doppler flowmetry; SBF: Skin blood flow; SBFO: Skin blood flow oscillation; PORH: Postocclusive reactive hyperemia; SHR: Spontaneously hypertensive rats; WKY: Wistar-Kyoto rats; LDF: Laser-Doppler flowmetry; LDI: Laser Doppler Imaging; BP: Blood pressure.
Comparação de custos de tratamentos de controle de plantas daninhas em abacaxizeiro cultivado no Rio Grande do Sul, Brasil (2010)

Objetivando reduzir custos foi calculada a eficiência agroeconômica (> produtividade < custo) de cinco tratamentos de controle de plantas daninhas em ensaio conduzido de 27/03/05 a 23/02/07 na Fepagro, Maquiné, RS, delineado em blocos casualizados, cinco repetições dos tratamentos: T1-Capina; T2-Glyphosate (2,5 L i.a. ha-1); T3-Diuron(2,4 L i.a. ha-1) T4-Diuron+Glyphosate (2,4 + 2,5 L i.a. ha-1); T5-Atrazine+ Simazine (3,0 L i.a. ha-1). Calculou-se o custo da capina a partir da remuneração diária do operário, do preço, em g mL-1, dos princípios ativos e da receita bruta (no frutos x preço na região) de cada tratamento. O preço do g mL-1 do atrazine+simazine variou 25 %, do glyphosate, 32 % e do diuron, 107 %. O custo dos tratamentos foi: T1 = R$ 2736,00; T5= R$ 653,00; T2 = R$ 629,00; T4= R$ 621,00 e T3= R$ 468, 00 ha-1 ano-1, respectivamente, 9, 3, 6, 5 e 2 % da receita. O controle de plantas daninhas com herbicidas custou 22 % do montante gasto com capinas-T1C e o diuron-T3D, aplicado a intervalos de 55 dias, foi o tratamento mais barato, custou 74 % do preço médio dos demais tratamentos com herbicidas.
Radical addition to carbonyl carbon promoted by aqueous titanium trichloride: stereoselective synthesis of .alpha.,.beta.-dihydroxy ketones (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRadical addition to carbonyl carbon promoted by aqueous titanium trichloride: stereoselective synthesis of .alpha.,.beta.-dihydroxy ketonesAngelo Clerici and Ombretta PortaCite this: J. Org. Chem. 1989, 54, 16, 3872–3878Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://doi.org/10.1021/jo00277a025RIGHTS & PERMISSIONSArticle Views1142Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (998 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Supplementary Figure 1 from EpCAM Modulates NF-κB Signaling and Interleukin-8 Expression in Breast Cancer (2023)

&lt;p&gt;PDF file - 108K, EpCAM and IL-8 microarray expression data from 1881 breast cancer plotted in box plot.&lt;/p&gt;
Fiber-optic technology for IBM Enterprise systems (1993)

The IBM System/390 :sup.*:esup. family of mainframe computers is among the first in the computer industry to use fiber optic I/ O channels for high speed data transfer. Known as ESCON (Enterprise Systems Connection) :sup.*:esup channels, these optical links provide significantly higher bandwidth, data rates, and distance than the parallel electrical cables which they replace. The ESCON :sup.*:esup. channels consist of 200 Megabit/s duplex fiber optic links (17 Megabytes/s). Multimode links using 1300 nm LED transmitters and PIN photodiode receivers allow a maximum unrepeated distance of 3 km using 62.5 micron core fiber and 2 km using 50 micron core fiber with a minimum modal bandtvidth of 800 Mhz-km. A single-mode version using InGaAsP laser diodes increases the unrepeated distance to 20 km while maintaining international class 1 laser safety. This paper describes the optical, electrical, and mechanical design innovations of the ESCON :sup.*:esup. channels. Optical link budget modeling will be discussed, as well as design of a duplex optical connector and cable strain relief system. Experimental data will be presented on link performance in harsh environments such as elevated levels of ionizing (gamma) radiation, or customized link designs which can extend the maximum unrepeated distance.
Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma (2018)

High-risk neuroblastoma, a predominantly TP53 wild-type (wt) tumour, is incurable in >50% patients supporting the use of MDM2 antagonists as novel therapeutics. Idasanutlin (RG7388) shows in vitro synergy with chemotherapies used to treat neuroblastoma. This is the first study to evaluate the in vivo efficacy of the intravenous idasanutlin prodrug, RO6839921 (RG7775), both alone and in combination with temozolomide in TP53 wt orthotopic neuroblastoma models. Detection of active idasanutlin using liquid chromatography-mass spectrometry and p53 pathway activation by ELISA assays and Western analysis showed peak plasma levels 1 h post-treatment with maximal p53 pathway activation 3-6 h post-treatment. RO6839921 and temozolomide, alone or in combination in mice implanted with TP53 wt SHSY5Y-Luc and NB1691-Luc cells showed that combined RO6839921 and temozolomide led to greater tumour growth inhibition and increase in survival compared to vehicle control. Overall, RO6839921 had a favourable pharmacokinetic profile consistent with intermittent dosing and was well tolerated alone and in combination. These preclinical studies support the further development of idasanutlin in combination with temozolomide in neuroblastoma in early phase clinical trials.
Cassandra: distributed access control policies with tunable expressiveness (2004)

We study the specification of access control policy in large-scale distributed systems. Our work on real-world policies has shown that standard policy idioms such as role hierarchy or role delegation occur in practice in many subtle variants. A policy specification language should therefore be able to express this variety of features smoothly, rather than add them as specific features in an ad hoc way, as is the case in many existing languages. We present Cassandra, a role-based trust management system with an elegant and readable policy specification language based on Datalog with constraints. The expressiveness (and computational complexity) of the language can be adjusted by choosing an appropriate constraint domain. With just five special predicates, we can easily express a wide range of policies including role hierarchy, role delegation, separation of duties, cascading revocation, automatic credential discovery and trust negotiation. Cassandra has a formal semantics for query evaluation and for the access control enforcement engine. We use a goal-oriented distributed policy evaluation algorithm that is efficient and guarantees termination. Initial performance results for our prototype implementation have been promising.
A backward update strategy for location management in personal communication networks (2005)

The design of a cost-effective location management mechanism is very important in wireless personal communication networks (PCNs). This work presents a backward location update scheme compatible with the location management strategy used in current PCNs. In our design, the visitor location register (VLR) employs an intelligent micro-procedure, which distinguishes different types of location movements and performs different location update procedures. The location information stored in the home location register (HLR) is backward updated on demand necessarily for a call or short message delivery. Thus, the proposed scheme is able to save significant amount of traffic cost and database overhead.
Piezophotonic switching due to local field effects in a coherently prepared medium of three-level atoms (1995)

We recently discovered an error in the numerical evaluation of Eq. (
Donald J. Willower (2001)

Reviews the extraordinary contribution made to educational administration by Donald J. Willower who died in January, 2000. During his 40 years at The Pennsylvania State University Willower made a profound contribution to the field in general and to the study of values, leadership, pupil control ideology, organisation theory, change, and methods of inquiry in particular. Willower was Distinguished Professor of Education for the closing decade of his career – an appropriate acknowledgment of his outstanding teaching, research, and professional service to the field. For 20 years he was a member of the Editorial Advisory Board of JEA .
αCaMKII controls the establishment of cocaine's reinforcing effects in mice and humans (2014)

Although addiction develops in a considerable number of regular cocaine users, molecular risk factors for cocaine dependence are still unknown. It was proposed that establishing drug use and memory formation might share molecular and anatomical pathways. Alpha-Ca(2+)/calmodulin-dependent protein kinase-II (αCaMKII) is a key mediator of learning and memory also involved in drug-related plasticity. The autophosphorylation of αCaMKII was shown to accelerate learning. Thus, we investigated the role of αCaMKII autophosphorylation in the time course of establishing cocaine use-related behavior in mice. We found that αCaMKII autophosphorylation-deficient αCaMKII(T286A) mice show delayed establishment of conditioned place preference, but no changes in acute behavioral activation, sensitization or conditioned hyperlocomotion to cocaine (20 mg kg(-1), intraperitoneal). In vivo microdialysis revealed that αCaMKII(T286A) mice have blunted dopamine (DA) and blocked serotonin (5-HT) responses in the nucleus accumbens (NAcc) and prefrontal cortex after acute cocaine administration (20 mg kg(-1), intraperitoneal), whereas noradrenaline responses were preserved. Under cocaine, the attenuated DA and 5-HT activation in αCaMKII(T286A) mice was followed by impaired c-Fos activation in the NAcc. To translate the rodent findings to human conditions, several CAMK2A gene polymorphisms were tested regarding their risk for a fast establishment of cocaine dependence in two independent samples of regular cocaine users from Brazil (n=688) and Switzerland (n=141). A meta-analysis across both samples confirmed that CAMK2A rs3776823 TT-allele carriers display a faster transition to severe cocaine use than C-allele carriers. Together, these data suggest that αCaMKII controls the speed for the establishment of cocaine's reinforcing effects.
Multidimensional Ti3C2TxMXene ArchitecturesviaInterfacial Electrochemical Self-Assembly (2021)

An effective pathway to build macroscopic scale functional architectures bearing diverse structural dimensions is one of the critical challenges in the two-dimensional (2D) MXene research area. Unfortunately, assembling MXene without adhesive binder is largely limited due to its innate brittle nature and the relatively weak inter-flake van der Waals contact, in contrast to other mechanically compliant 2D materials such as graphene. Herein, an electrochemical self-assembly of pure Ti<sub>3</sub>C<sub>2</sub>T<sub><i>x</i></sub> MXenes is presented for functional multidimensional MXene structures, effectively driven by layer-by-layer spontaneous interfacial reduction at metal template surfaces and subsequent defunctionalization. A three-dimensional open porous aerogel as well as 2D highly stacked thin film structures could be readily obtained in this approach, along with largely enhanced electrical properties induced by spontaneous removal of charge-trapping oxygen functional groups. Accordingly, supercapacitors and electromagnetic interference shielding films based on the multidimensional assembly demonstrate excellent performances.
Autophagy is activated in human spermatozoa subjected to oxidative stress and its inhibition impairs sperm quality and promotes cell death (2022)

This work was supported by the Fondo Nacional de Investigación Científica y Tecnológica, Chile (ANID/FONDECYT, Grant number 11170758 to P.U.); the Comisión Nacional de Investigación Científica y Tecnológica, Chile (ANID/CONICYT, Grant number PAI79160030 to P.U.) and the Dirección de Investigación, Universidad de La Frontera. The authors disclose no potential conflicts of interest.
From Nuclear Science to Bacterial Cytochromes: the Work of Martin D. Kamen (2010)

Martin David Kamen (1913–2002) was born in Toronto, Canada, but grew up in Chicago. He enrolled at the University of Chicago in 1930, intending to study English. However, the Great Depression took a toll on his family's finances, and his father suggested he switch his major to chemistry in order to make a living after graduating. By his junior year, Kamen was hooked on chemistry. He graduated in 1933 with honors in physical chemistry, working with William Draper Harkins to determine ammonia gas emission spectra excited by electrodeless discharge.
<b>The effect of mazindol on insulin and glucagon secretion in rats with ventromedial hypothalamic </b><b>obesity </b> (1988)

The effect of mazindol on insulin and glucagon secretion was studied in ventromedial hypothalamic (VMH)-lesioned obese rats with hyperinsulinemia. Three weeks after a VMH or sham operation, the rats were divided into two groups: one was fed a balanced diet containing mazindol (50 mg/kg) and the other was fed a balanced diet without mazindol for 3 weeks. In the VMH rats, mazindol treatment was associated with a significant reduction in body weight and calorie intake, but it had no effect in the sham-operated rats. Furthermore, the fasting plasma insulin level and the arginine-induced insulin secretion from the perfused pancreas of VMH rats treated with mazindol were significantly lower than those in VMH rats without mazindol treatment. In addition, mazindol produced no significant change in the insulin secretion of sham-operated rats either in vivo or in vitro. It is therefore suggested that mazindol suppresses the hypersecretion of insulin in VMH rats through an anorectic effect and/or suppression of vagal hyperactivity.
Phenylimidorhenium(V) Complexes with 1,3‐Diethyl‐4,5‐dimethylimidazole‐2‐ ylidene Ligands (2006)

Abstract The phenylimidorhenium(V) complexes [Re(NPh)X 3 (PPh 3 ) 2 ] (X = Cl, Br) react with the N‐heterocyclic carbene (NHC) 1,3‐diethyl‐4,5‐dimethylimidazole‐2‐ylidene (L Et ) under formation of the stable rhenium(V) complex cations [Re(NPh)X(L Et ) 4 ] 2+ (X = Cl, Br), which can be isolated as their chloride or [PF 6 ] − salts. The compounds are remarkably stable against air, moisture and ligand exchange. The hydroxo species [Re(NPh)(OH)(L Et ) 4 ] 2+ is formed when moist solvents are used during the synthesis. The rhenium atoms in all three complexes are coordinated in a distorted octahedral fashion with the four NHC ligands in equatorial planes of the molecules. The Re–C(carbene) bond lengths between 2.171(8) and 2.221(3) Å indicate mainly σ‐bonding between the NHC ligand and the electron deficient d 2 metal atoms. Attempts to prepare analogous phenylimido complexes from [Re(NPh)Cl 3 (PPh 3 ) 2 ] and 1,3‐diisopropyl‐4,5‐dimethylimidazole‐2‐ylidene (L i−Pr ) led to a cleavage of the rhenium‐nitrogen multiple bond and the formation of the dioxo complex [ReO 2 (L i−Pr ) 4 ] + .
Game Changers (2021)

This chapter examines the literature and business opportunities surrounding K-12 eSports, competitive events where athletes play video games against each other. Topics include an overview of existing scholastic eSports offerings and organizations that facilitate competition, the effects on student athletes' physical and mental health, the growth of eSports venues, and the identification of research gaps and business opportunities related to increasing eSports access for younger student athletes and their communities.
Sustained Reduction in Cardiac Monitor Alarms in a Pediatric Bone Marrow Transplant Unit (2018)

Background: Alarm fatigue creates desensitization and results in missed alarms. In 2013, a standardized cardiac monitor care process (CMCP) was created and implemented in a large pediatric bone marrow transplant (BMT) unit which resulted in a substantial reduction in cardiac monitor alarms. The aim of this project was to determine the variables associated with sustained adherence and transferability. Methods: Using quality improvement methodology, a standardized CMCP was developed and implemented: 1) initial ordering of monitor parameters based on age appropriate standards; 2) daily replacement of electrodes; 3) daily individualized assessment of monitor parameters; 4) reliable method for monitor discontinuation. Standardized processes included: monitor care log to address parameters, lead changes, and discontinuation; pain free electrode removal; customized monitor delay and threshold parameters. Daily individualize assessment of cardiac monitor settings was later substituted by a standardized algorithm to address excessive alarms. After sustaining intervention results on the BMT unit, the advanced bundle was spread to the oncology unit. Results: From January to November 2013, percent compliance with each of the CMCP four components increased with an overall compliance from a median of 38% to 95%. Median number of alarms per patient day decreased from 180 to 40. Removal of the daily individualized assessment of the monitor alarms was tested with a standardized algorithm to address frequent alarms, which was successful and associated with continued alarm reduction over three years (median of 30 alarms/patient day). The revised bundle spread to the oncology unit reducing the number of alarms from 100 to 30 and sustained for 18 months. Discussion: Implementation of the modified CMCP, 1) initial ordering of monitor parameters based on age appropriate standards; 2) daily replacement of electrodes; 3) standardized algorithm to address excessive alarms; 4) reliable method for discontinuation of monitor have resulted in a sustainable and transferable alarm reduction.
Figure S1 from Identification of Tissue-Specific DNA Methylation Signatures for Thyroid Nodule Diagnostics (2023)

&lt;p&gt;Genes associated with DDMS locations are frequently linked to cancer according to Ingenuity® Pathway Analysis (Qiagen Inc.). Number of genes in each group is indicated.&lt;/p&gt;