gebhart/patrepeval huggingface dataset:
Anticipation-based temporal pattern generation (1995)

A neural network model of complex temporal pattern generation is proposed and investigated analytically and by computer simulation. Temporal pattern generation is based on recognition of the contexts of individual components. Based on its acquired experience, the model actively yields system anticipation, which then compares with the actual input flow. A mismatch triggers self-organization of context learning, which ultimately leads to resolving various ambiguities in producing complex temporal patterns. The architecture of the model incorporates a short term memory for building associations between remote components and recurrent connections for self-organization and component generation in a temporal pattern. Synaptic modification is based on a one-shot normalized Hebbian rule, which is shown to exhibit temporal masking. The major conclusion, namely the network model which can learn to generate any complex temporal pattern, is established analytically. An estimate on the efficiency of the training algorithm is provided. Multiple temporal patterns can be incrementally acquired by the system, exhibiting a form of retroactive interference. Neural and cognitive plausibility of the model is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Table 1 from Relationship between Complete Pathologic Response to Neoadjuvant Chemotherapy and Survival in Triple-Negative Breast Cancer (2023)

&lt;p&gt;Patient Characteristics&lt;/p&gt;
Islet Cell Surface Antibodies and Lymphocyte Antibodies in the Spontaneously Diabetic BB Wistar Rat (1982)

Plasma from 14 diabetic and 6 nondiabetic BB Wistar rats along with plasma from 6 non-BB Wistar rats was evaluated for the presence of islet cells surface antibodies (ICSA) and antibodies to spleen lymphocytes by the protein-A radioligand assay. Dispersed Wistar rat islet cells incubated with plasma from diabetic rats bound 4255 +/- 2208 cpm 125I-protein A/5 x 10(4) islet cells (mean +/- SD) compared with 984 +/- 454 cpm/5 x 10(4) islet cells in islet cells incubated with plasma from nondiabetic BB rats (P less than 0.005). Twelve of the 14 diabetic rats with a duration of diabetes for 3-11 days bound radioactivity above the mean and 2 x SC of controls. The binding of 125I-protein A did not differ between nondiabetic BB rats and non-BB Wistar rats. Wistar rat spleen lymphocytes incubated in diabetic plasma bound 20,249 +/- 10,783 cpm/2 x 10(6) spleen lymphocytes compared with 3460 +/- 1809 in the controls (P less than 0.005). Animals positive for ICSA correlated with those positive for spleen lymphocyte antibodies. It is concluded that ICSA and splenic lymphocyte antibodies are present in diabetic BB rats.
<p>The Polysubstance Overdose-Death Crisis</p> (2020)

In the late 1990s and early 2000s, it was recognized that an increasing number of people were dying from opioid overdose, and regulatory agencies, professional societies, and legislative bodies actively adopted and promulgated efforts to reduce the "epidemic". Yet, despite multiple guidelines, legislative enactions (often draconian), and attempts at legal and financial-penalty remedies, death rates continue to climb. The literature is now replete with the terms "opioid-induced respiratory depression" and "opioid overdose death" to describe the cause of death in many of these cases. Unfortunately, this terminology is too simplistic and now woefully outdated. It understates the complexities of these deaths, and the fact that the majority of overdose deaths currently involve multiple substances -that is, it is now a polysubstance-overdose death crisis.
Higher-order Kalman filter to support fast target tracking in a multi-function radar system (1999)

State-of-the-art multi-function radars to support area defence systems are currently under development-these allow steered searchlight-type looks to be performed in 3D and will provide the capability to track targets via both surveillance (search) looks and, additionally, looks dedicated to a specific track. Central to the derivation of this tracking capability is the development of a fast target track smoothing algorithm within these systems-this smoother will utilise associating plot outputs to update existing fast target tracks. As well as supporting weapon systems functions, the track data is also used as the basis for scheduling future looks, thus closing the loop in the radar system. A conventional approach to the tracking of fast targets is to utilise a Kalman filter using a system model based on the assumption of constant target velocity. However, the increased manoeuvrability of projected threats compromises the fundamental assumption of constant velocity, thereby limiting the potential performance of such an approach. A candidate solution is to utilise a higher order filter (HOF) which specifically embraces the possibility of target manoeuvre. While this addresses the problem, the formulation of the filter must necessarily include increased uncertainty in the assumed target behaviour. This results in larger covariances being attributed to the estimated position and velocity of tracked objects, resulting in reduced accuracy in the derived estimates of target heading in the important case of straight line target motion. A hybrid solution is possible, where a constant velocity filter is adopted as the baseline solution and a switching regime selects the HOF only when necessary. Such an approach retains all the benefits of the constant velocity approach in the regimes where its performance advantages occur. This paper describes a candidate switching approach, together with the structure of the selected second order filter, and illustrates the comparative performance against a conventional constant velocity filter approach.
The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein (1987)

In a previous study, the most abundant viral transcript in a human papillomavirus type 16-associated cervical cancer and in a cancer-derived cell line was characterized, and its translation product, the E7 protein, was identified (D. Smotkin and F. O. Wettstein, Proc. Natl. Acad. Sci. USA 68:4680-4684, 1986). Here we show that the E7 protein had a half life of about 1 h and was located in the soluble cytoplasmic fraction. The protein was phosphorylated at serine residues and exhibited a high heterogeneous sedimentation rate in nondenaturing glycerol gradients, suggesting an oligomer formation or association with cellular protein.
Final report - Magma Energy Research Project (1982)

Scientific feasibility was demonstrated for the concept of magma energy extraction. The US magma resource is estimated at 50,000 to 500,000 quads of energy - a 700- to 7000-yr supply at the current US total energy use rate of 75 quads per year. Existing geophysical exploration systems are believed capable of locating and defining magma bodies and were demonstrated over a known shallow buried molten-rock body. Drilling rigs that can drill to the depths required to tap magma are currently available and experimental boreholes were drilled well into buried molten rock at temperatures up to 1100/sup 0/C. Engineering materials compatible with the buried magma environment are available and their performances were demonstrated in analog laboratory experiments. Studies show that energy can be extracted at attractive rates from magma resources in all petrologic compositions and physical configurations. Downhole heat extraction equipment was designed, built, and demonstrated successfully in buried molten rock and in the very hot margins surrounding it. Two methods of generating gaseous fuels in the high-temperature magmatic environment - generation of H/sub 2/ by the interaction of water with the ferrous iron and H/sub 2/, CH/sub 4/, and CO generation by the conversion of water-biomass mixtures - have been investigated and show promise.
Production of electrostatically charged biomolecules by induction charging of a liquid jet with Fourier transform infrared spectrometry detection (1994)

The Particle Beam LC/FT-IR interface has been modified so that the aerosol produced can be electrostatically charged by the induction charging (IC) technique. Manipulation of the beam of uniformly charged particles, by electrodynamics using potential arrays, in addition to physical alignment, enhances analyte transport efficiency. The emphasis of this work involves FT-IR analysis of biomolecules prepared from an electrostatic aerosol. With IC, and potential influence over the trajectories, collection of the desolvated biomolecule can be achieved without the high-energy impact associated with normal particle beam operation, an ideal situation for conformation studies in which structure is often affected by the harsh collision. In this work the globular proteins, (alpha) -Chymotrypsin, Papain, and the amino acid d,l- Tryptophan were electrostatically charged by the IC technique, and deposited onto IR- transparent substrates which produced films that were examined by FT-IR.
Differential effects of Rad52p overexpression on gene targeting and extrachromosomal homologous recombination in a human cell line (2002)

Overexpression of the RAD52 epistasis group of gene products is a convenient way to investigate their in vivo roles in homologous recombination (HR) and DNA repair. Overexpression has the further attraction that any associated stimulation of HR may facilitate gene-targeting applications. Rad51p or Rad52p overexpression in mammalian cells have previously been shown to enhance some forms of HR and resistance to ionising radiation, but the effects of Rad52p overexpression on gene targeting have not been tested. Here we show that Rad52p overexpression inhibits gene targeting while stimulating extrachromosomal HR. We also find that Rad52p overexpression affects cell-cycle distribution, impairs cell survival and is lost during extensive passaging. Therefore, we suggest that excess Rad52p can inhibit the essential RAD51-dependent pathways of HR most likely to be responsible for gene targeting, while at the same time stimulating the RAD51-independent pathway thought to be responsible for extrachromosomal HR. The data also argue against Rad52p overexpression as a means of promoting gene targeting, and highlight the limitations of using a single HR assay to assess the overall status of HR.
Separation mechanism of oleanane and ursane pentacyclic triterpenoid isomers by coordination chromatography (2014)

This paper focuses on the study of the separation mechanism of oleanane and ursane pentacyclic triterpenoid isomers by a coordination chromatographic method. Based on the calculation analysis, beta-cyclodextrin (beta-CD) and its derivatives were selected as the suitable agents. The experimental results showed that the resolution of madecassoside isomers with the addition of glucosyl-beta-cyclodextrin (Glu-beta-CD) to the mobile phase (11.95) was higher than that of the addition of beta-CD (9.61) or dimethyl-beta-cyclodextrin (DM-beta-CD) (9.89). The formation of 1:1 inclusion complexes was assumed. The apparent formation constants (K(F)) of pentacyclic triterpenes with beta-CD were determined by HPLC method. For asiaticoside-B, the K(F) value with the addition of Glu-beta-CD (2 534 L/mol) was larger than that with the addition of beta-CD (1 467 L/mol) or DM-beta-CD (1 373 L/mol). According to the infrared characteristic absorbing peaks and simulation, the methyl part of asiaticoside-B might enter into beta-CD cavity while the carbonyl group of asiaticoside-B might not enter into the cavity of beta-CD, and the large glycoside parts were kept outside, forming hydrogen-bond interaction with the exterior of beta-CD cavity. The results of the separation of oleanane and ursane pentacyclic triterpenoid isomers by coordination chromatography indicated that, the separation mechanism might be attributed to the steric differences (the place of methyl group in E cyclic), which lead to different chromatographic behaviors.
High-performance and low-cost dual-thread VLIW processor using Weld architecture paradigm (2005)

This paper presents a cost-effective and high-performance dual-thread VLIW processor model. The dual-thread VLIW processor model is a low-cost subset of the Weld architecture paradigm. It supports one main thread and one speculative thread running simultaneously in a VLIW processor with a register file and a fetch unit per thread along with memory disambiguation hardware for speculative load and store operations. This paper analyzes the performance impact of the dual-thread VLIW processor, which includes analysis of migrating disambiguation hardware for speculative load operations to the compiler and of the sensitivity of the model to the variation of branch misprediction, second-level cache miss penalties, and register file copy time. Up to 34 percent improvement in performance can be attained using the dual-thread VLIW processor when compared to a single-threaded VLIW processor model.
Information Visualization Heuristics in Practical Expert Evaluation (2016)

While traditional HCI heuristics can be used to find usability issues also from information visualization systems, specialized heuristics tailored for the information visualization (InfoViz) domain can be more effective and focus on the special characteristics of these systems. In this study, we describe the application of ten information visualization heuristics from prior research and their testing in practical heuristic evaluation. We found that the selected heuristics were useful with good coverage in our application case. However, based on our observations, we argue that interaction, veracity, and aesthetics related heuristics should be added to the previously used set. The lack of domain knowledge made the evaluators somewhat uneasy with their capability to carry out the investigation in-depth. We suggest to train domain experts with understanding of the data and application domain to carry out the evaluation to get insightful feedback beyond usability issues.
Design of a Physiologic Pulsatile Flow Cardiopulmonary Bypass System for Neonates and Infants (1996)

Cardiopulmonary bypass surgical techniques that allow a surgeon to operate on the infant's heart use an extracorporeal circuit consisting of a pump, oxygenator, arterial and venous reservoirs, cannulae, an arterial filter, and tubing. The extracorporeal technique currently used in infants and neonates is sometimes associated with neurologic damage. We are developing a modified cardiopulmonary bypass system for neonates that has been tested in vitro and in one animal in vivo. Unlike other extracorporeal circuits which use steady flow, this system utilizes pulsatile flow, a low prime volume (500 ml) and a closed circuit. During in vitro experiments, the pseudo patient's mean arterial pressure was kept constant at 40 mmHg and the extracorporeal circuit pressure did not exceed a mean pressure of 200 mmHg. In our single in vivo experiment, the primary objective was to determine whether physiologic pulsatility with a 10 F (3.3 mm) aortic cannula could be achieved. The results suggest that this is possible.
Renal Hemodynamic and Functional Effects of 10 Days’ Partial Urinary Obstruction in the Fetal Lamb (1994)

We studied fetal lambs to define the renal pathophysiology of chronic in utero partial bladder outlet obstruction. These fetal lambs, 115 to 120 days gestation (term = 145 days), underwent urethral ligation, placement of a urachal catheter and positioning of an ultrasonic flow transducer around the left renal artery. Partial obstruction was created by placing a narrow connector between the urachal and an amniotic catheter. In control animals a large connector was placed to allow free drainage of the bladder into the amniotic cavity. Renal blood flow was measured daily, and urine was collected at days 5 and 10 to evaluate renal function. In control animals, no significant changes in any parameters were observed. In the partially obstructed fetal lambs, renal blood flow increased to 165% of baseline after 5 days; from 5 to 10 days, it decreased, but remained above baseline values through 10 days (128%). Urine production dropped significantly after 10 days (67%). Glomerular filtration rate increased slightly after 5 days (127%), but decreased after 10 (56%). Filtration fraction steadily decreased after 5 (70%) and 10 days (33%). Fractional and total sodium excretion did not change. Renal blood flow increases, filtration fraction decreases and renal function trends progressively diminish in response to partial bladder outlet obstruction over a period of 10 days in the fetal lamb.
Detection of dyslipoproteinemia with the use of plasma total cholesterol and triglyceride as screening tests. The Lipid Research Clinics Program Prevalence Study. (1986)

The efficiency of screening for dyslipoproteinemias associated with hyperlipoproteinemia or with hypolipoproteinemia was examined in 8449 white examinees from the Lipid Research Clinics Prevalence Study. A two-stage lipid screening approach was used. A positive screening test for hyperlipidemia was defined as an elevated level of plasma total cholesterol or triglyceride at both visit 1 and visit 2. A positive screening test for hypolipidemia was defined as a reduced plasma total cholesterol level at both visits. The syndromes of dyslipoproteinemia were defined according to the lipoprotein pattern present at visit 2. When hyperlipidemia was used as a screening tool, generally only about one-half or less of the cases of hyperlipoproteinemia were detected (high proportion of false-negative results). Of all the hyperlipidemic participants, more than 80% had hyperlipoproteinemias (type I, IIa, IIb, III, IV, or V), and such lipid screening therefore provided a lower proportion of false-positive than false-negative results. Most of the participants (greater than 98%) without hyperlipoproteinemia were correctly identified (true negatives). The efficiency of screening for hypolipoproteinemia was in general poorer than that found for hyperlipoproteinemia. Our results were found to be related, in part, to the marked regression to the mean of plasma cholesterol and triglycerides at the extremes of the distributions and to the wide variety of dyslipoproteinemias that can be present within a given range of plasma cholesterol or triglyceride values. The results emphasize the importance of measuring plasma lipoproteins in the patient who is being evaluated for dyslipoproteinemia.
Hitzebeständige und flammfeste fasern. Eine neue klasse: Die aromatischen polyamid‐imide (1974)

Abstract Es besteht ein immer größer werdender Bedarf an hitzebeständigen und flammfesten Fasern. Unter diesen Fasern wurde eine neue Klasse mit dem Warenzeichen Kermel geschaffen : die aromatischen Polyamid‐Imide. Verschiedene Verfahren zur Herstellung dieser Polymeren werden betrachtet. Ein Direktpolykondensationsverfahren durch Verarbeitung von Trimellitsäureanhydrid und aromatischen Diisocyanaten wird beschrieben. Die Viskositätszahl und die mechanischen Eigenschaften der entsprechenden Fäden hängen wesentlich von dem Lösungsmittel, dem Diisocyanat bzw. von einem anderen difunktionellen Comonomeren ab. Die auf den herkömmlichen Wegen der Naß‐ oder Trockenverspinnung hergestellten Fasern zeichnen sich durch ihre hohe Hitzebeständigkeit und Flammfestigkeit, zusammen mit günstigen textilen Eigenschaften im Vergleich zu anderen Fasern aus. Auf Grund ihrer spezifischen Eigenschaften eignen sich diese Fasern besonders für hochsichere Schutzkleidung, flammfeste Heimtextilien und einige andere technische Einsatzgebiete.
Antiestrogens suppress effects of transforming growth factor-β in breast cancer cells via the signaling axis estrogen receptor-α and Y-box Binding Protein-1. (2013)

High levels of YB1 expression lead to a stimulation of TGFβ pathways, thereby counteracting antihormonal breast cancer therapy and representing a putative resistance mechanism.
Microfluidic Arrays for Rapid Characterization of Organic Thin‐Film Transistor Performance (2011)

Structure-processing-property relationships in solution processable organic semiconducting polymers are both complex and important. High throughput screening techniques present a potential advantage in defining empirical relationships between processing conditions and device performance. Using microfluidic devices and a substrate annealing gradient system large arrays of organic thin-film transistors (OTFTs) are fabricated from poly(didodecylquaterthiophene-alt-didodecylbithiazole). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Abstract 98: Antiphospholipid Antibodies Induce Thrombosis by Activating Endothelial PP2A via ApoER2-Dab2-PSD95 Complex Formation (2016)

In the antiphospholipid syndrome (APS), patients generate antiphospholipid antibodies (aPL) that promote thrombosis. We previous showed that aPL recognition of the endothelial cell surface protein β2-Glycoprotein I (β2GPI) causes β2GPI to interact with the LDL receptor family member ApoER2 and thereby antagonize endothelial NO synthase (eNOS). The decrease in bioavailable NO then leads to exaggerated thrombus formation. In the present work we sought to determine how aPL and the β2GPI-ApoER2 tandem antagonize eNOS. Initial experiments employed co-immunoprecipitation, RNAi-based gene silencing and adenoviral introduction of mutant proteins into human aortic endothelial cells. We discovered that in contrast to normal human IgG from healthy subjects (NHIgG), aPL invoke the formation of a complex between the cytoplasmic tail of ApoER2 and Dab-2 and PSD95, and that the formation of the complex is required for eNOS antagonism. We also found that ApoER2-Dab2-PSD95 complex formation in response to aPL potently activates the serine/threonine phosphatase PP2A, which in turn dephosphorylates eNOS-S1179, thereby extinguishing eNOS enzymatic activity. Furthermore, we found that upon aPL treatment, the PP2A catalytic and regulatory subunits are recruited to the ApoER2-Dab2-PSD95 complex. To test if these processes are operative in APS-related thrombosis in vivo, intravital microscopy of the mesenteric microcirculation was employed to evaluate thrombus formation in mice. In wild-type mice, aPL administration caused exaggerated thrombus formation compared to treatment with NHIgG. In contrast, ApoER2 did not promote thrombosis in knock-in ApoER2-EIG mice harboring a mutant receptor incapable of interacting with Dab-2. Moreover, in wild-type mice aPL treatment caused a dramatic increase in PP2A activity in the aorta, and administration of the PP2A inhibitor Endothall fully prevented thrombus formation induced by aPL. Having revealed the molecular underpinnings of the disorder, current treatment of APS with anticoagulation, which is often ineffective and fraught with complications, can potentially be replaced by new mechanism-based therapies targeting ApoER2 complex formation or PP2A.