gebhart/patrepeval huggingface dataset:
Biodegradable fibrous scaffolds composed of gelatin coated poly(ϵ‐caprolactone) prepared by coaxial electrospinning (2007)

A facile coaxial electrospinning technique was devised to prepare biodegradable core-shell fibrous scaffolds with poly(epsilon-caprolactone) (PCL) comprising the core structure and gelatin forming the coating of the fibers. The effect of the feed rate of the inner dope on the electrospinning process and fiber morphology was investigated. The results indicated that core-shell fibers with narrow size distribution and smooth surface morphology could be obtained when the feed rate was below 8 mL/h. An increase of the feed rate resulted in analogous increase in the diameters of both the inner PCL fiber core and the entire core-shell fibers. XPS analyses revealed that the surface of the core-shell fibers was tainted with a small amount of PCL. The outer gelatin layer in the core-shell fibers was crosslinked with glutaraldehyde. By optimizing the glutaraldehyde/gelatin feed ratio, crosslinked scaffolds with high porosity were obtained. The mechanic strength of the hydrated, crosslinked core-shell fibrous scaffolds was significantly enhanced because of the presence of hydrophobic PCL in the core region of the fibers. Results of cell culture studies suggested that the crosslinked, core-shell fibrous scaffold were nontoxic and capable of supporting fibroblast adhesion and proliferation.
Analisis Tingkat Kesenjangan Bantuan Pangan Non Tunai (BPNT) dan Dampaknya terhadap Daya Beli Masyarakat Muslim (2022)

Research on Non-Cash Food Assistance (BPNT) from the aspect of equity, it turns out that no one has done it yet. Therefore, this thesis is here to discuss this matter, and herein lies the difference from the results of previous research on BPNT. In researching BPNT from the aspect of equity, a quantitative approach is used for the methodological aspects and Islamic economics for the scientific aspects. To realize these two approaches, an equity model is used in discussing the gap in Non-Cash Food Assistance (BPNT) in Cenrana District, Bone Regency. In proving this, two research questions are proposed, namely: (1) What is the level of inequality in Non-Cash Food Assistance (BPNT) that occurs in Cenrana District, Bone Regency? and (2) What is the impact on the purchasing power of Muslim communities in Cenrana District, Bone Regency. To answer the two research questions, statistical data obtained from each of the seven villages in Cenrana is needed, and also supported by documentation to strengthen the research results. The statistical data were analyzed using a quantitative approach through the Microsoft Excel application, and the results were interpreted using the theory of income distribution and sharia maqasid. The results show: (1) The BPNT gap that occurred in Cenrana District, Bone Regency from 2018-2020 is a moderate (normal) gap, where in 2018 the gap was at the point of 0.45789 then in 2019 the Gini ratio point showed 0.46709 and in 2020 it is at the point of 0.46293 and the Lorenz curve tends to experience an ideal distribution line. (2) The impact on the purchasing power of the Muslim community in Cenrana District, Bone Regency, is a decrease in purchasing power. Due to inequality in the distribution of non-cash food assistance (BPNT).
Coherent plane-wave compounding and minimum variance beamforming (2011)

Achieving increased frame rate without compromising the image quality is desirable in medical ultrasound imaging. Coherent plane-wave compounding has recently been suggested as an approach to achieve this. This work proposes to generate coherent compound plane-wave images using a minimum variance adaptive beamformer. Through simulations of point scatterers and cyst phantoms, a threefold increase in frame rate is shown.
References (2012)

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Comparison of the therapeutic effectiveness of human CD34+ and rat bone marrow mesenchymal stem cells on improvement of experimental liver fibrosis in Wistar rats. (2016)

Taken together; human UCB CD34<sup>+</sup> stem cells were more efficient in improvement of experimental liver injury than BM-MSCs. This study highlighted an important role of human UCB CD34<sup>+</sup> stem cells in liver fibrosis therapy.
Cell Wall and Extensin mRNA Changes during Cold Acclimation of Pea Seedlings (1990)

During exposure to 2 degrees C, pea (Pisum sativum) seedlings cold acclimated to a killing temperature of -6 degrees C. Associated with this increase in freezing resistance was an increase in the weight of cell walls and changes in wall composition. Arabinosyl content increased by 100%, while other cell wall glycosyl residues and cellulose increased by about 20%. The cell wall hydroxyproline content increased by 80%. Arabinose and hydroxyproline are both major components of the structural cell wall glycoprotein, extensin. The increase in these components indicates that the level of extensin in the cell wall increases during cold acclimation. Northern blot analysis, using the pDC5A1 genomic clone as a probe, revealed a more than three-fold increase in total extensin mRNA during exposure to cold temperature. Specific extensin transcripts of 6.0, 4.5, 3.5, 2.6, 2.3, 1.8, and 1.5 kilobases were identified. Those at 6.0, 2.6, and 1.5 kilobases were especially promoted by low temperature treatment. The rise in extensin during cold acclimation may be regulated, at least in part, at the gene level. The possible structural role of this protein in freezing protection is discussed.
A Structural and Functional Analysis of α-Glucan Recognition by Family 25 and 26 Carbohydrate-binding Modules Reveals a Conserved Mode of Starch Recognition (2005)

Starch-hydrolyzing enzymes lacking alpha-glucan-specific carbohydrate-binding modules (CBMs) typically have lowered activity on granular starch relative to their counterparts with CBMs. Thus, consideration of starch recognition by CBMs is a key factor in understanding granular starch hydrolysis. To this end, we have dissected the modular structure of the maltohexaose-forming amylase from Bacillus halodurans (C-125). This five-module protein comprises an N-terminal family 13 catalytic module followed in order by two modules of unknown function, a family 26 CBM (BhCBM26), and a family 25 CBM (BhCBM25). Here we present a comprehensive structure-function analysis of starch and alpha-glucooligosaccharide recognition by BhCBM25 and BhCBM26 using UV methods, isothermal titration calorimetry, and x-ray crystallography. The results reveal that the two CBMs bind alpha-glucooligosaccharides, particularly those containing alpha-1,6 linkages, with different affinities but have similar abilities to bind granular starch. Notably, these CBMs appear to recognize the same binding sites in granular starch. The enhanced affinity of the tandem CBMs for granular starch is suggested to be the main biological advantage for this enzyme to contain two CBMs. Structural studies of the native and ligand-bound forms of BhCBM25 and BhCBM26 show a structurally conserved mode of ligand recognition but through non-sequence-conserved residues. Comparison of these CBM structures with other starch-specific CBM structures reveals a generally conserved mode of starch recognition.
Circulating Immune Complexes during Various Forms of Renal Allograft Rejection Episodes (1982)

Previous reports on the nephritogenic and immunological enhancing capacity of posttransplant circulating immune complexes (CICs) are conflicting and have been confined to the study of acute rejection episode (AR). This study was undertaken to assess the nephritogenicity of CICs in patients undergoing accelerated acute rejection (AAR) and chronic rejection (CR) episodes. We also assessed the possible role of CICs as mediators of immunological enhancement by assessing CIC levels in long-term-stable allograft recipients. To asses the nephritiogenic role of CICs, 98 CIC determinations were performed on 49 serum samples from 41 pediatric renal transplant recipients using the C1q solid-phase assay (C1q-SPA) and the Raji cell radioimmunoassay (Raji-RIA). Serum samples from normal subjects served as controls. No recipient undergoing AAR had evidence of CICs by eigher assay. 5 of 21 (23.8%) recipients undergoing CR had positive CIC levels in the Raji-RIA, while 4 of 21 (19%) recipients had positive CICs inthe C1q-SPA. There was no statistically significant correlation of CIC levels with long-term allograft function. In addition, there was no evidence supporting antithymocyte globulin as an immunogen in patients demonstrating posttransplant CICs. In summary, CICs do not appear to be an important mediator of AAR or CR episodes, and CICs were not routinely detected in patients with good long-term allograft function.
Electroconvulsive and Neuromodulation Therapies (2009)

Electroconvulsive therapy (ECT) is a psychiatric treatment involving the induction of a seizure through the transmission of electricity in the brain. Because of exploitation movies and greatly heightened drug company promotional activities ECT was used less frequently in the 1980s and 1990s. Eventually these movies were understood as unrealistic. Now these drugs are increasingly recognized as dangers to body health. Because of recent refinements and a far better scientific understanding of the clinical procedures and mechanisms underpinning ECT, this treatment modality has seen a resurgence in use and widespread appreciation of its safety. This book is the new definitive reference on electroconvulsive and neuromodulation therapies. It comprehensively covers the scientific basis and clinical practice of ECT as well as comparisons between ECT and medication therapies including the new generation of antipsychotic drugs. It also provides readers with administrative perspectives and specific details for the management of this modality in clinical practice. The new forms of nonconvulsive electrical and magnetic brain stimulation therapy are also covered in detail, in a separate section. The chapter authors are leading scholars and clinicians.
Human diploid fibroblast-like cells (CF-3) as a model system for the study of Golgi biogenesis (1980)

Human diploid fibroblast-like cells were maintained in an arrested, essentially non-mitotic state for extended periods of time in culture by lowering the serum concentration in the medium from 10 to 0.5%. These arrested cells re-entered the proliferative state when subcultivated in medium containing 10% serum. The morphological distribution and enzyme activities associated with the Golgi complex were examined during growth, arrest, and recovery. Cells grown in medium containing 10% serum possessed a well-developed Golgi complex consisting of parallel arrays of membranes and associated vesicles. Galactosyl transferase activity was highest after 3 days growth (17.5 +/- 5.0 nmol galactose transferred/45 min/mg protein) and declined to 9.8 +/- 3.0 at day 7. When the serum concentration was reduced to 0.5%, Golgi complexes were rarely observed by electron microscopy and galactosyl transferase activity was further reduced into medium containing 10% serum recovered from the arrested state and ultrastructurally resembled cells continuously cultured at the higher serum level. Numerous Golgi complexes reappeared and galactosyl transferase activity increased to 13.0 +/- 3.34 days after subcultivation. These results indicate that the Golgi complex can be experimentally manipulated in human diploid fibroblast-like cells in a manner which may be useful for the study of the biogenesis of this organelle.
The SemIoTic Ecosystem: A Semantic Bridge between IoT Devices and Smart Spaces (2022)

Smart space administration and application development is challenging in part due to the semantic gap that exists between the high-level requirements of users and the low-level capabilities of IoT devices. The stakeholders in a smart space are required to deal with communicating with specific IoT devices, capturing data, processing it, and abstracting it out to generate useful inferences. Additionally, this makes reusability of smart space applications difficult, since they are developed for specific sensor deployments. In this article, we present a holistic approach to IoT smart spaces, the SemIoTic ecosystem, to facilitate application development, space management, and service provision to its inhabitants. The ecosystem is based on a centralized repository, where developers can advertise their space-agnostic applications, and a SemIoTic system deployed in each smart space that interacts with those applications to provide them with the required information. SemIoTic applications are developed using a metamodel that defines high-level concepts abstracted from the smart space about the space itself and the people within it. Application requirements can be expressed then in terms of user-friendly high-level concepts, which are automatically translated by SemIoTic into sensor/actuator commands adapted to the underlying device deployment in each space. We present a reference implementation of the ecosystem that has been deployed at the University of California, Irvine and is abstracting data from hundreds of sensors in the space and providing applications to campus members.
Fast dissolving Drug delivery system : Review Article (2010)

Swallowing a pill is a major difficulty encountered in case of geriatric and pediatric patient which leads to poor patient compliance due to unpalatable taste of drug. To troubleshoot these problems a new dosage form known as fast-dissolving tablet (FDT), has been developed which rapidly disintegrate and dissolve in saliva. FDT are intended and designed to disintegrate and dissolve in saliva and then easily swallowed without need of water which is a major benefit over conventional dosage form. These dosage forms are also used to attain instant a higher concentration of drug in body for immediate actions. Fast dissolving tablets can be prepared by various conventional methods like direct compression, wet granulation, moulding, spray drying, freeze drying, and sublimation. In 1986, the first lyophilized fast-dissolving technology Zydis® was introduced by Cardinal formerly R. P. Scherer and after that there was a continuous growth in names , technologies & patented technology by different companies. Now a number of fast-dissolving formulations are in market like Claritin Reditab (Manufacturer R.P.Scherr,Inc.), Risperdal M-Tab (Manufacturer Janseen pharmaceutics.), Tempra Quicklets (Manufacturer Cima Labs,inc) and the technology is still improving. Present review focuses on the need of FDTs, pros and cons, drugs/marketed preparations, manufacturing process involved, evaluation of products and future trend.
ChemInform Abstract: FLUORIDE‐INDUCED FRAGMENTATION OF TRIMETHYLSILYLOXY SULFONATES TO CIS‐BONDED HEXAHYDROAZULENONES (1981)

Abstract Die photochemische Reaktion von Cyclopenten (I) mit dem Silylether (II) liefert die Cyclobutan‐Derivate (III) und (IV) im Verhältnis 3 :2.
Integrating monitoring and inspection with attached ultrasonic transducers (2006)

Ultrasonic methods are widely applied for nondestructive evaluation of structural components during both the manufacturing process and subsequent field inspections. The field inspections often require expensive teardown in order to access the back surfaces of critical components. Active ultrasonic methods are also a subject of ongoing research for structural health monitoring whereby transducers are permanently attached to a structure and signals are monitored to detect changes caused by structural damage. This paper presents a methodology for effectively combining ultrasonic monitoring and inspection. During the monitoring phase, detection and localization of possible damage is demonstrated on several specimens using attached transducers. This detection phase is followed by demonstration of a new inspection method referred to as Acoustic Wavefield Imaging (AWI) which utilizes the attached transducers as sources and a single externally scanned air-coupled transducer as a receiver. The acoustic wavefield images are useful for both checking the viability of the attached transducers and quantifying the extent of damage. The AWI method approaches the sensitivity of conventional through transmission ultrasonic methods but does not require access to both sides of structural components. Thus, it is very well suited for rapid field inspection of structural assemblies.
Estimating diffusion properties in complex fiber configurations based on structure-adaptive multi-valued tensor-field filtering (2015)

Conventionally, a single rank-2 tensor is used to assess the white matter integrity in diffusion imaging of the human brain. However, a single tensor fails to describe the diffusion in fiber crossings. Although a dual tensor model is able to do so, the low signal-to-noise ratio hampers reliable parameter estimation as the number of parameters is doubled. We present a framework for structure-adaptive tensor field filtering to enhance the statistical analysis in complex fiber structures. In our framework, a tensor model will be fitted based on an automated relevance determination method. Particularly, a single tensor model is applied to voxels in which the data seems to represent a single fiber and a dualtensor model to voxels appearing to contain crossing fibers. To improve the estimation of the model parameters we propose a structure-adaptive tensor filter that is applied to tensors belonging to the same fiber compartment only. It is demonstrated that the structure-adaptive tensor-field filter improves the continuity and regularity of the estimated tensor field. It outperforms an existing denoising approach called LMMSE, which is applied to the diffusion-weighted images. Track-based spatial statistics analysis of fiber-specific FA maps show that the method sustains the detection of more subtle changes in white matter tracts than the classical single-tensor-based analysis. Thus, the filter enhances the applicability of the dual-tensor model in diffusion imaging research. Specifically, the reliable estimation of two tensor diffusion properties facilitates fiber-specific extraction of diffusion features.
Characterization of RACK7 as a Novel Factor Involved in BRCA1 Mutation Mediated Breast Cancer (2012)

Abstract : Though BRCA1 has been shown to play a role in DNA end resection, likely critical in the cell s decision to undergo homologous recombination or non-homologous end joining repair pathways, much of BRCA1 function remains unknown. To identify genes that cooperate with BRCA1 in DNA damage response and tumor suppression, we performed a lentiviral vector based cDNA library screen. ZMYND8 (zinc finger Mynd-type containing 8), previously Rack7 (receptor for activated C kinase) or Prkcbp1 (protein kinase C binding protein 1), was identified in our screen as a candidate gene that could modulate the DNA damage hypersensitivity in cells lacking BRCA1. Biochemical data indicates that ZMYND8 might be involved in chromatin reorganization surrounding a stalled fork, which may be vital in preventing collapse and granting genomic stability. Overexpression of ZMYND8 in breast, ovarian, and several other malignancies, could be a novel mechanism to overcome replica-tion stress resulting from BRCA1 dysfunction. This suggests that ZMYND8 and BRCA1 could function epistatically, a phenomenon we continue to investigate using our lab-generated mouse models. In conclusion, our novel findings demonstrate that ZMYND8 is required to prevent the reversal of stalled replication forks, and thereby contributes to the preservation genomic stability under replication stress.
Bit allocation for dependent quantization with applications to MPEG video coders (1993)

The problem of efficient bit allocation in a dependent coding environment is addressed. Techniques of optimal bit allocation for independently coded signal blocks are extended to the more general dependent coding scenarios. Of particular interest is the topical MPEG (Motion Picture Experts Group) video coder. It is shown how a certain monotonicity property of dependent operational rate-distortion (R-D) curves, verified through MPEG simulations, can be exploited in formulating fast ways to obtain optimal and near-optimal solutions (in the R-D sense) for the MPEG bit allocation problem.< <ETX>&gt;</ETX>
Richardson v. State: An Opportunity Missed (1971)

1. -Ind.-, 266 N.E.2d 51 (1971).2. Apparently, another grand jury member was called to testify at the defendant's trial.He was also unable to repeat the defendant's testimony verbatim and was allowed to read from the transcript.3. Throughout this note the dissenting opinion referred to is that of Judge DeBruler.Judge Prentice also filed a dissent which substantially agreed with Judge DeBruler's.4. The majority reaffirmed Indiana's recognition of the doctrine of present memory revived and in dictum rejected the doctrine of past recollection recorded.-Ind.at-, 266 N.E.2d at 53.The dissent agreed with the majority on this point:There is no question that a witness may use a written memo to refresh his memory concerning past events. . . .[W]hen this is permitted, the evidence concerning the past events is the testimony relating the independent recollection of the witness and not the written memo.Id. at -, 266 N.E.2d at 55.The court first adopted the doctrine of present memory revived in Clark v. State, 4 Ind. 156 (1853). It is obvious
Macrophage-stimulating protein inhibits induction of nitric oxide production by endotoxin- or cytokine-stimulated mouse macrophages. (1994)

Human serum macrophage-stimulating protein (MSP) is a disulfide-linked heterodimer that induces motile and phagocytic activity of mouse resident peritoneal macrophages. In this work, we found that MSP blocked the increase in macrophage nitric oxide synthase mRNA, as well as the associated increase in nitric oxide production, that occurred in response to several stimuli. These included bacterial products and mammalian cytokines: endotoxin, and interferon-gamma plus endotoxin, interleukin-2, or tumor necrosis factor-alpha. The inhibition by MSP of induction of nitric oxide synthase mRNA and nitric oxide secretion was concentration-dependent. The concentration of MSP that caused maximal inhibition of nitric oxide production was comparable with the optimum for stimulation of macrophage motile and phagocytic activity. Time course studies showed that nitrite was first detected in culture fluid about 8 h after endotoxin stimulation, and it accumulated at a linear rate during the ensuing 16 h. Inhibition by MSP occurred during the 8-h lipopolysaccharide (LPS) induction period; inhibition was maximal when MSP and LPS were added together and decreased progressively to no inhibition as the interval between LPS and MSP addition increased to 11 h.
Optical Rotation of Noncovalent Aggregates (2003)

Dilute solutions of (R)-(-)-pantolactone in CCl4 were studied by polarimetry in conjunction with theoretical calculations of [alpha]D. Our data demonstrate that the self-association of a chiral solute results in a change in [alpha]D that can be accounted for by the presence of hydrogen-bonded dimeric species. The theoretical analysis predicts a concentration-dependent specific rotation in good agreement with experiment. Further exploration of monomer and dimer [alpha]D differences, through atomic map analysis, reveals large contributions to [alpha]D from the hydrogen-bonded hydroxyl groups in the tightly-coupled dimer. This study extends the computation of chiroptical properties to the accurate concentration-dependent prediction of [alpha]D for noncovalently interacting self-associating species.