gebhart/patrepeval huggingface dataset:
Inkjet fabrication of spiral frequency-steerable acoustic transducers (FSATs) (2012)

The frequency-based beam steering concept effectively supports Guided-Wave-based Structural Health Monitoring (SHM) by enabling directional waveguide inspection. This is implemented by acoustic transducers whose peculiar shapes provide different wavelength tuning in different directions. When these devices are used for guided wave (GW) sensing, spatial filtering of the propagating wavefield results in a prominent frequency component within the recorded signal spectrum, which can be uniquely associated with the direction of an incoming wave. A sensor geometry whose 2D spatial Fourier Transform produces a spiral-like distribution of maxima in the wavenumber domain allows for one-to-one frequency-angle correspondence in the [0&deg;, 180&deg;] range. Prototypes of this wavenumber spiral frequency steerable acoustic transducer (WS-FSAT) have been fabricated by patterning the electrodes' shape on a metallized polyvinylidene fluoride (PVDF) substrate through inkjet printing. Prototype testing in various pitch-catch configurations demonstrates accurate 2D localization of acoustic sources and scattering events by processing a single output signal. Extremely easy, quick and inexpensive fabrication approach, along with very low hardware and computational requirements make the proposed FSAT an ideal candidate for a wide range of in-situ, low-cost and wireless SHM applications.
P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation (2007)

By removing the fastest degrees of freedom, constraints allow for an increase of the time step in molecular simulations. In the last decade parallel simulations have become commonplace. However, up till now efficient parallel constraint algorithms have not been used with domain decomposition. In this paper the parallel linear constraint solver (P-LINCS) is presented, which allows the constraining of all bonds in macromolecules. Additionally the energy conservation properties of (P-)LINCS are assessed in view of improvements in the accuracy of uncoupled angle constraints and integration in single precision.
On the decidability of phase ordering problem in optimizing compilation (2006)

We are interested in the computing frontier around an essential question about compiler construction: having a program P and a set M of non parametric compiler optimization modules (called also phases), is it possible to find a sequence s of these phases such that the performance (execution time for instance) of the final generated program P′ is "optimal" ? We prove in this article that this problem is undecidable in two general schemes of optimizing compilation: iterative compilation and library optimization/generation. Fortunately, we give some simplified cases when this problem be-comes decidable, and we provide some algorithms (not necessary efficient) that can answer our main question. Another essential question that we are interested in is parame-ters space exploration in optimizing compilation (tuning optimizing compilation parameters). In this case, we assume a fixed sequence of optimization, but each optimization phase is allowed to have a parameter. We try to figure out how to compute the best parameter values for all program transformations when the compilation sequence is given. We also prove that this general problem is undecidable and we provide some simplified decidable instances.
Abstract 3868: Identification of PHLPP1 as a novel metastasis suppressor in melanoma . (2013)

Abstract Metastatic dissemination is the cause of nearly all melanoma-related deaths. Despite an improving understanding of genetic lesions present in human melanomas, how these alternations relate to the metastatic process is not well understood. Previously, we found that activation of the PI3K/Akt pathway is a driving force in metastatic melanomas. Here we identify PHLPP1 as a novel metastasis suppressor in melanoma. PHLPP1 was recently identified as a Ser/Thr-specific phosphatase, belonging to pleckstrin homology (PH) domain leucine-rich repeat protein phosphatase family. The two isoforms of this family, PHLPP1 and PHLPP2 control kinase signaling in the AKT family by catalyzing the dephosphorylation of the hydrophobic phosphorylation motif. PHLPP1 can specifically dephosphorylate AKT2 and AKT3, whereas PHLPP2 dephosphorylates AKT1 and AKT3. To study the role of PHLPPs in metastatic melanoma, we first examined the expression of PHLPPs in 30 melanoma metastases, 30 primary melanomas, and 9 normal skin tissues using tissue microarray analysis. We found that PHLPP1 was significantly downregulated or lost in metastatic melanoma samples, but not PHLPP2. Moreover, analysis of various human melanoma cell lines (12 highly metastatic, 14 poorly metastatic melanoma cell lines and 1 normal melanoctye cell line) demonstrated that PHLPP1 expression correlated with metastatic behavior, supporting the notion that PHLPP1 is involved in the metastatic regulation of melanoma. To confirm a functional role for PHLPP1 in metastasis, we forced the expression of PHLPP1 and PHLPP2 in B16 and A375sm melanoma cell lines. Overexpression of PHLPP1 dramatically inhibited metastasis in both cell lines. Unexpectedly, the PHLPP2 isoform had little influence on metastatic ability in both cell lines in vivo, despite the fact that both PHLPP1 and PHLPP2 were able to inhibit in vitro cell proliferation, motility, migration as well as colony formation in soft agar. Notably, introduction of PH mutant forms of PHLPP1 still blunted the metastatic potential of both cell lines, whereas a phosphatase-deficient C-terminal mutant did not affect metastasis. Interestingly, transfected AKT2 active form could rescue PHLPP1-mediaed inhibition of metastasis. Our data demonstrate at the first time that PHLPP1 plays a critical role in inhibiting metastasis through its phosphatase activity, and suggest that PHLPP1 could be a diagnostic marker and therapeutic target for metastatic melanoma. Citation Format: Yanlin Yu, Andrew Lu, Meng Dai, Glenn Merlino. Identification of PHLPP1 as a novel metastasis suppressor in melanoma . [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3868. doi:10.1158/1538-7445.AM2013-3868
Correlation of Perfusion Parameters with Genes Related to Angiogenesis Regulation in Glioblastoma: A Feasibility Study (2012)

Our findings are provocative, with some of the proangiogenic genes showing a positive correlation and some of the antiangiogenic genes showing an inverse correlation with tumor perfusion parameters, suggesting a molecular basis for these imaging biomarkers; however, this should be confirmed in a larger patient population.
Standardized combined cryotherapy and compression using Cryo/Cuff after wrist arthroscopy (2010)

there was no significant effect of additional home-based combined cryotherapy and compression using the Cryo/Cuff wrist bandage, following wrist arthroscopy regarding pain, swelling, range of motion, and subjective impairment assessed using the DASH score over 3 weeks in comparison with the control group.
Should a viral genome stay in the host cell or leave? A quantitative dynamics study of how hepatitis C virus deals with this dilemma (2020)

Virus proliferation involves gene replication inside infected cells and transmission to new target cells. Once positive-strand RNA virus has infected a cell, the viral genome serves as a template for copying ("stay-strategy") or is packaged into a progeny virion that will be released extracellularly ("leave-strategy"). The balance between genome replication and virion release determines virus production and transmission efficacy. The ensuing trade-off has not yet been well characterized. In this study, we use hepatitis C virus (HCV) as a model system to study the balance of the two strategies. Combining viral infection cell culture assays with mathematical modeling, we characterize the dynamics of two different HCV strains (JFH-1, a clinical isolate, and Jc1-n, a laboratory strain), which have different viral release characteristics. We found that 0.63% and 1.70% of JFH-1 and Jc1-n intracellular viral RNAs, respectively, are used for producing and releasing progeny virions. Analysis of the Malthusian parameter of the HCV genome (i.e., initial proliferation rate) and the number of de novo infections (i.e., initial transmissibility) suggests that the leave-strategy provides a higher level of initial transmission for Jc1-n, whereas, in contrast, the stay-strategy provides a higher initial proliferation rate for JFH-1. Thus, theoretical-experimental analysis of viral dynamics enables us to better understand the proliferation strategies of viruses, which contributes to the efficient control of virus transmission. Ours is the first study to analyze the stay-leave trade-off during the viral life cycle and the significance of the replication-release switching mechanism for viral proliferation.
Electrostatic Force–Driven Oxide Heteroepitaxy for Interface Control (2018)

Oxide heterostructure interfaces create a platform to induce intriguing electric and magnetic functionalities for possible future devices. A general approach to control growth and interface structure of oxide heterostructures will offer a great opportunity for understanding and manipulating the functionalities. Here, it is reported that an electrostatic force, originating from a polar ferroelectric surface, can be used to drive oxide heteroepitaxy, giving rise to an atomically sharp and coherent interface by using a low-temperature solution method. These heterostructures adopt a fascinating selective growth, and show a saturation thickness and the reconstructed interface with concentrated charges accumulation. The ferroelectric polarization screening, developing from a solid-liquid interface to the heterostructure interface, is decisive for the specific growth. At the interface, a charge transfer and accumulation take place for electrical compensation. The facile approach presented here can be extremely useful for controlling oxide heteroepitaxy and producing intriguing interface functionality via electrostatic engineering.
Reliable large acceptance optical fibers for high-power transmission (2005)

Typically, output from high power, diode lasers and arrays must be transported to a final application/treatment site, whether the application is industrial, military or medical. Many demands are placed on optical fibers to couple the laser output into their structures and to transmit the power to the application site. All silica fibers become much more expensive as the diameter of the fiber increases to handle larger spot sizes and higher NA beams, especially from diode arrays. High strength, low fatigue Hard Plastic Clad Silica fibers provide benefits of larger Numerical Aperture (NA), more flexibility and less strain at the core-clad interface. Fibers with these characteristics and available in both high OH and low OH versions for UV and NIR spectral regions are described. Short and long term strength, and spectral properties are presented. Results for a new high NA version are also presented.
The characteristics of the older dialysis population—heterogeneity and another type of altered risk factor patterns (2017)

The number of older dialysis patients is increasing in many countries. For example, the trend is linked to the increase in the dialysis patients 70 years of age and over in Japan. Older dialysis patients often experience deteriorating physical and psychological functions, and special consideration for older patients has been focused on improving or preventing such deteriorations. On the other hand, from the standpoint of clinical studies, the distribution of clinical parameters, clinical outcomes, and their associations of older dialysis patients differ from those of younger patients. Moreover, they exhibit heterogeneous phenotypes. Health age may be more important than the chronological age in considering older patients. Since the age is the most powerful predictor of survival, clinical interventions might have little benefit on the very old dialysis patients. Therefore, maintaining the quality of life or activity of daily living might surpass survival regarding the goal of management of very old dialysis patients. Above all, individualized management according to the heterogeneity or health age are necessary for the older dialysis patients. Future clinical studies of older dialysis patients are needed for the better understanding of this population.
{sup 17}O NMR investigation of oxidative degradation in polymers under gamma-irradiation (2000)

The {gamma}-irradiated-oxidation of pentacontane (C{sub 50}H{sub 102}) and the polymer polyisoprene was investigated as a function of oxidation level using {sup 17}O nuclear magnetic resonance (NMR) spectroscopy. It is demonstrated that by using {sup 17}O labeled O{sub 2} gas during the {gamma}-irradiation process, details about the oxidative degradation mechanisms can be directly obtained from the analysis of the {sup 17}O NMR spectra. Production of carboxylic acids is the primary oxygen-containing functionality during the oxidation of pentacontane, while ethers and alcohols are the dominant oxidation product observed for polyisoprene. The formation of ester species during the oxidation process is very minor for both materials, with water also being produced in significant amounts during the radiolytic oxidation of polyisoprene. The ability to focus on the oxidative component of the degradation process using {sup 17}O NMR spectroscopy demonstrates the selectivity of this technique over more conventional approaches.
[Thyroid function tests and their use by the general practitioner]. (1993)

The GPs carried out few FTFs; but those they did were very efficient. Cost was low and patients benefited from the fact that their GPs were able to use this technique. Endocrinology referrals were reasonable. All general practitioners should have use of TFTs.
Design of the Dynamic RBF Neural Network Based on the Sensitivity Analysis of Model Output (2009)

Due to the unchangable structure of conventional RBF(radial basis function) neural networks in the learning process,a new structure of dynamic RBF neural network is designed.The presented algorithm is based on the sensitivity analysis(SA) on the model output of neural network.The redundant nodes in the hidden layer is pruned by judging the effect of the output of the nodes in the hidden layer on the whole network output,and thus the dynamic pruning of the neural network is accomplished.The results of approximating non-linear functions and modeling the non-linear systems show the perfect performance of this algorithm,and comparing with the Minimal RBF(MRBF) neural network,the proposed SARBF can achieve the smaller testing error,the shorter training time and a compact neural network structure.
Fascaplysin Derivatives Are Potent Multitarget Agents against Alzheimer’s Disease: in Vitro and in Vivo Evidence (2019)

Alzheimer's disease (AD) is characterized by progressive neurodegeneration and impaired cognitive functions. Fascaplysin is a β-carboline alkaloid isolated from marine sponge <i>Fascaplysinopsis bergquist</i> in 1988. Previous studies have shown that fascaplysin might act on acetylcholinesterase and β-amyloid (Aβ) to produce anti-AD properties. In this study, a series of fascaplysin derivatives were synthesized. The cholinesterase inhibition activities, the neuronal protective effects, and the toxicities of these compounds were evaluated <i>in vitro</i>. Compounds <b>2a</b> and <b>2b</b>, the two most powerful compounds <i>in vitro</i>, were further selected to evaluate their cognitive-enhancing effects in animals. Both <b>2a</b> and <b>2b</b> could ameliorate cognitive dysfunction induced by scopolamine or Aβ oligomers without affecting locomotor functions in mice. We also found that <b>2a</b> and <b>2b</b> could prevent cholinergic dysfunctions, decrease pro-inflammatory cytokine expression, and inhibit Aβ-induced tau hyperphosphorylation <i>in vivo</i>. Most importantly, pharmacodynamics studies suggested that <b>2b</b> could penetrate the blood-brain barrier and be retained in the central nervous system. All these results suggested that fascaplysin derivatives are potent multitarget agents against AD and might be clinical useful for AD treatment.
Improvements in the Safety and Efficiency of Air Traffic (2016)

1．はじめに 学会発表などで国内外に出張する際に，航空機を使用する機会は多くあることだろう。空港に行くと，短い時間間隔で次々に離着陸する航空機を見ることができる。何時間見ていても飽き
Breast Reconstruction with Implants, Tissue Expanders and AlloDerm: Predicting Volume and Maximizing the Skin Envelope in Skin Sparing Mastectomies (2009)

AlloDerm has been used as a tissue supplement in conjunction with the pectoralis major muscle to provide full coverage over an implant in breast reconstruction. While this method of reconstruction has shown promising results there is little known on the relationship of AlloDerm size and potential immediate expansion volume. A retrospective chart review was completed evaluating all tissue expander or primary implant reconstructions using AlloDerm. Data recorded included: The type/size of implant/expander, dimensions of the AlloDerm used, initial fill volume, number of expansions and time period of expansion. Statistical analysis was completed with a linear regression model. AlloDerm was used on 49 patients (72 reconstructions). Thirty-four patients (50 reconstructions) underwent reconstruction with a tissue expander and 15 patients (22 reconstructions) underwent a single stage reconstruction with a permanent implant. The tissue expander volume filled (cc) could be predicted by 5 x surface area of AlloDerm (cm(2)) - 12 (R(2) = 0.62) and 80 x height of AlloDerm (cm) - 15 (R(2) = 0.59). The tissue expanders could be filled to an average of 75% of total size and required three to four injections in the postoperative period to reach full expansion. Obviously, a requirement for maximal implant expansion is an appropriate skin sparing mastectomy. There is a mathematical relationship between fill volume and surface area as well as height of AlloDerm used in breast reconstruction. This analysis provides a guideline for immediate implant expansion to surgeons using AlloDerm in reconstructive breast surgery.
Novel endoscopic management of penetrating intracranial trauma. (2010)

We report a unique case of minimally invasive endoscopic removal of a penetrating orbitocranial foreign body (POCFB), and present a review of the literature. A 12-year-old boy was impaled in the orbit with a gate latch. Neurosurgical consultation ascertained that removal via bifrontal craniotomy would necessitate extensive brain retraction and result in permanent anosmia. Attempting nasal endoscopic removal was deemed prudent, given this morbidity and a lack of brain parenchymal violation. The patient recovered without a cerebrospinal fluid leak or other neurologic sequelae. To date, craniotomy is the only reported management of POCFBs in the literature. We herein report the first nasal endoscopic removal of a POCFB.
Nanometric aperture arrays fabricated by wet and dry etching of silicon for near-field optical storage application (1999)

We fabricated nanometric aperture arrays in order to apply to an optical probe in high-density near-field optical storage for increase of data-transmission rate. The aperture arrays were fabricated by forming concave pyramidal grooves on a silicon-on-insulator wafer with electron beam lithography and wet anisotropic etching. Modification of the apex shape of the grooves by re-oxidation and subsequent reactive ion dry etching was able to increase the uniformity of the aperture size remarkably. The light transmission efficiency of the fabricated apertures was measured to be ∼10−3 when the aperture size was 100 nm, which was higher than that of a conventional optical fiber probe by several orders of magnitude.
Michellamines A6 and A7, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese Ancistrocladus liana and their antiausterity activities against pancreatic cancer cells (2018)

Michellamines A<sub>6</sub> (1) and A<sub>7</sub> (2) are the first dimers of 5,8'-coupled naphthylisoquinoline alkaloids with <i>cis</i>-configured stereocenters in both tetrahydroisoquinoline subunits. They were isolated from the leaves of a recently discovered, yet unidentified Congolese <i>Ancistrocladus</i> liana that shares some morphological characteristics with <i>Ancistrocladus likoko</i>. Two further new dimeric analogs, michellamines B<sub>4</sub> (3) and B<sub>5</sub> (4), were obtained, along with two previously likewise unknown monomers, ancistrobonsolines A<sub>1</sub> (5) and A<sub>2</sub> (6), which, besides one single known other example, are the only naphthyldihydroisoquinolines with an <i>M</i>-configured biaryl axis and <i>R</i>-configuration at C-3. Moreover, five compounds earlier reported from other <i>Ancistrocladus</i> species were identified, ancistroealaine C (7), korupensamines A (8a) and B (8b), and michellamines A<sub>2</sub> (9) and E (10). Their complete structural elucidation succeeded due to the fruitful interplay of spectroscopic, chemical, and chiroptical methods. Chemotaxonomically, the stereostructures of the metabolites clearly delineate this Congolese <i>Ancistrocladus</i> liana from all known related species, showing that it might be a new taxon. Ancistrobonsolines A<sub>1</sub> (5) and A<sub>2</sub> (6) exhibited strong preferential cytotoxicities against human PANC-1 pancreatic cancer cells under nutrient-deprived conditions, without displaying toxicity in normal, nutrient-rich medium. Against cervical HeLa cancer cells, the dimeric alkaloids michellamines A<sub>6</sub> (1) and E (10) displayed the highest cytotoxic activities, comparable to that of the standard agent, 5-fluorouracil. Furthermore, ancistrobonsolines A<sub>1</sub> (5) and A<sub>2</sub> (6) showed weak-to-moderate antiprotozoal activities.
A Riboswitch-Based Inducible Gene Expression System for Mycobacteria (2012)

Research on the human pathogen Mycobacterium tuberculosis (Mtb) would benefit from novel tools for regulated gene expression. Here we describe the characterization and application of a synthetic riboswitch-based system, which comprises a mycobacterial promoter for transcriptional control and a riboswitch for translational control. The system was used to induce and repress heterologous protein overexpression reversibly, to create a conditional gene knockdown, and to control gene expression in a macrophage infection model. Unlike existing systems for controlling gene expression in Mtb, the riboswitch does not require the co-expression of any accessory proteins: all of the regulatory machinery is encoded by a short DNA segment directly upstream of the target gene. The inducible riboswitch platform has the potential to be a powerful general strategy for creating customized gene regulation systems in Mtb.
La radiochirurgie par gamma knife dans la pathologie des nerfs crâniens: Aspects thérapeutiques et approche pluridisciplinaire (2001)

SCOPUS: ar.j
Multispectral Endoscopic Imaging Enabled by Mapping Spectral Bands into the Time Domain (2016)

Rapid multispectral confocal imaging is performed with a single shot-limited detector. This approach uses fiber delay lines to map spectral bands into the time domain, and has been integrated with fiber bundles for endoscopic applications.
319 (2015)

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