gebhart/patrepeval huggingface dataset:
Near-infrared fluorescence imaging of lymphatics in head and neck lymphedema (2011)

Treatment of lymphatic disease is complicated and controversial, due in part to the limited understanding of the lymphatic system. Lymphedema (LE) is a frequent complication after surgical resection and radiation treatment in cancer survivors, and is especially debilitating in regions where treatment options are limited. Although some extremity LE can be effectively treated with manual lymphatic drainage (MLD) therapy or compression devices to direct proximal lymph transport, head and neck LE is more challenging, due to complicated geometry and complex lymphatic structure in head and neck region. Herein, we describe the compassionate use of an investigatory technique of near-infrared (NIR) fluorescence imaging to understand the lymphatic anatomy and function, and to help direct MLD in a patient with head and neck LE. Immediately after 9 intradermal injections of 25 &mu;g indocyanine green each around the face and neck region, NIR fluorescence images were collected using a custom-built imaging system with diffused excitation light illumination. These images were then used to direct MLD therapy. In addition, 3-dimensional (3D) surface profilometry was used to monitor response to therapy. NIR fluorescence images of functioning lymphatic vessels and abnormal structures were obtained. Precise geometries of facial structures were obtained using 3D profilometry, and detection of small changes in edema between therapy sessions was achieved. NIR fluorescence imaging provides a mapping of lymphatic architecture to direct MLD therapy and thus improve treatment efficacy in the head and neck LE, while 3D profilometry allowed longitudinal assessment of edema to evaluate the efficacy of therapy.
Solubility of mixtures of hydrogen sulfide and carbon dioxide in aqueous N-methyldiethanolamine solutions (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubility of mixtures of hydrogen sulfide and carbon dioxide in aqueous N-methyldiethanolamine solutionsFang Yuan Jou, John J. Carroll, Alan E. Mather, and Frederick D. OttoCite this: J. Chem. Eng. Data 1993, 38, 1, 75–77Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/je00009a018https://doi.org/10.1021/je00009a018research-articleACS PublicationsRequest reuse permissionsArticle Views608Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Adaptive and Energy Efficient Walking in a Hexapod Robot Under Neuromechanical Control and Sensorimotor Learning (2015)

The control of multilegged animal walking is a neuromechanical process, and to achieve this in an adaptive and energy efficient way is a difficult and challenging problem. This is due to the fact that this process needs in real time: 1) to coordinate very many degrees of freedom of jointed legs; 2) to generate the proper leg stiffness (i.e., compliance); and 3) to determine joint angles that give rise to particular positions at the endpoints of the legs. To tackle this problem for a robotic application, here we present a neuromechanical controller coupled with sensorimotor learning. The controller consists of a modular neural network for coordinating 18 joints and several virtual agonist-antagonist muscle mechanisms (VAAMs) for variable compliant joint motions. In addition, sensorimotor learning, including forward models and dual-rate learning processes, is introduced for predicting foot force feedback and for online tuning the VAAMs' stiffness parameters. The control and learning mechanisms enable the hexapod robot advanced mobility sensor driven-walking device (AMOS) to achieve variable compliant walking that accommodates different gaits and surfaces. As a consequence, AMOS can perform more energy efficient walking, compared to other small legged robots. In addition, this paper also shows that the tight combination of neural control with tunable muscle-like functions, guided by sensory feedback and coupled with sensorimotor learning, is a way forward to better understand and solve adaptive coordination problems in multilegged locomotion.
Long-term recovery after hematopoietic cell transplantation: predictors of quality-of-life concerns (2010)

This prospective longitudinal study examined the quality of life (QOL) after hematopoietic cell transplantation (HCT) and identified risk factors of poor QOL in 312 adult autologous and allogeneic HCT patients. Physical, psychological, social, and spiritual well-being was assessed before HCT, 6 months, and 1, 2, and 3 years after HCT. For all HCT patients, physical QOL was stable from before to after HCT (P > .05); psychologic (P < .001), social (P < .001), and spiritual (P = .03) QOL improved at 6 months. Study noncompleters (because of illness or death) had worse QOL. Allogeneic patients reported worse physical and psychologic well-being (P < .05). Older patients reported worse physical but better social well-being regardless of HCT type (P < .05). Two or more domains were affected by race/ethnicity, household income, and education in autologous patients, and by body mass index (BMI), decline in BMI, primary diagnosis, and chronic graft-versus-host disease (GVHD) in allogeneic patients (P < .05). At 3 years, 74% of HCT patients were employed full or part time. Older autologous patients with lower pre-HCT income were less likely to work (P < .05); allogeneic patients with chronic GVHD were less likely to work (P = .002). Multidisciplinary efforts to identify and support vulnerable subgroups after HCT need to be developed.
ChemInform Abstract: A Comparison of Calculated and Experimental Hyperpolarizabilities for Acetonitrile in Gas and Liquid Phases (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mean and variance of implicitly defined biased estimators (such as penalized maximum likelihood): applications to tomography (1996)

Many estimators in signal processing problems are defined implicitly as the maximum of some objective function. Examples of implicitly defined estimators include maximum likelihood, penalized likelihood, maximum a posteriori, and nonlinear least squares estimation. For such estimators, exact analytical expressions for the mean and variance are usually unavailable. Therefore, investigators usually resort to numerical simulations to examine the properties of the mean and variance of such estimators. This paper describes approximate expressions for the mean and variance of implicitly defined estimators of unconstrained continuous parameters. We derive the approximations using the implicit function theorem, the Taylor expansion, and the chain rule. The expressions are defined solely in terms of the partial derivatives of whatever objective function one uses for estimation. As illustrations, we demonstrate that the approximations work well in two tomographic imaging applications with Poisson statistics. We also describe a "plug-in" approximation that provides a remarkably accurate estimate of variability even from a single noisy Poisson sinogram measurement. The approximations should be useful in a wide range of estimation problems.
The Standard Theatre of Victorian England (1993)

This book is the first major study of the Douglass family from 1848 to 1889 and the institution of the National Standard Theatre. Also detailed are the naturalistic staging techniques developed after 1879 that included railway trains on tracks, ocean liners, real water scenes, horse races, and other effects that later became part of the cinema.
SALIVARY PARAMETERS, ORAL HEALTH HABITS, AND SOCIOECONOMIC ASPECTS AS RISK FACTORS FOR DENTAL CARIES IN 12-YEAR-OLD CHILDREN FROM A PRIVATE SCHOOL OF THE CITY OF CURITIBA, BRAZIL (2005)

OBJECTIVES: The aim of this study was to compare socioeconomic aspects, oral health habits and salivary parameters between 12-year-old students with and without caries experience. MATERIAL AND METHODS: A sample of 113 non-related 12-year-old subjects was selected in a private school of Curitiba-PR, Brazil, for a case-control study. They were divided into groups with and without caries experience through the DMFT index. The frequency of tooth brushing, use of dental floss, diet, frequency of dentist visit, fluoride use, dental plaque index, socioeconomic aspects and salivary parameters were evaluated. Data were analyzed by qui-square and Mann-Whitney. RESULTS: Results showed no statistical difference between the groups in relation to oral hygiene habits and socioeconomic status. It was observed an association between dental plaque presence and caries experience, although not significant (p = 0.08). A reduced salivary flow was highly associated with decay experience (p = 0.00). CONCLUSION: It was concluded that the salivary flow was an important factor to determine dental caries experience in a homogeneous group of children from a private school of Curitiba-PR. Studies on host response aspects may be desirable in this kind of populations.
CCDC 1504174: Experimental Crystal Structure Determination (2016)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Awake functional MRI detects neural circuit dysfunction in a mouse model of autism (2020)

MRI has potential as a translational approach from rodents to humans. However, given that mouse functional MRI (fMRI) uses anesthetics for suppression of motion, it has been difficult to directly compare the result of fMRI in "unconsciousness" disease model mice with that in "consciousness" patients. We develop awake fMRI to investigate brain function in <i>15q dup</i> mice, a copy number variation model of autism. Compared to wild-type mice, we find that <i>15q dup</i> is associated with whole-brain functional hypoconnectivity and diminished fMRI responses to odors of stranger mice. Ex vivo diffusion MRI reveals widespread anomalies in white matter ultrastructure in <i>15q dup</i> mice, suggesting a putative anatomical substrate for these functional hypoconnectivity. We show that d-cycloserine (DCS) treatment partially normalizes these anormalies in the frontal cortex of <i>15q dup</i> mice and rescues some social behaviors. Our results demonstrate the utility of awake rodent fMRI and provide a rationale for further investigation of DCS therapy.
Multi-Modal Microscope for Biomedical Research (2006)

Microscopists often use different instruments to exploit the different types of contrast available in complicated biological media. A new multi-modal microscope makes it possible to acquire the different images nearly simultaneously, without moving the specimen. Rather than simply observing different contrast mechanisms in a specimen which has been moved, the user can now obtain registered images in different modes for image fusion or data fusion. The first application area is imaging of embryo health
Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire‐Injured Carotid Artery of Male Mice (2018)

Background We have reported that cytochrome P450 1B1 ( CYP 1B1), expressed in cardiovascular tissues, contributes to angiotensin II -induced vascular smooth muscle cell ( VSMC ) migration and proliferation and development of hypertension in various experimental animal models via generation of reactive oxygen species. This study was conducted to determine the contribution of CYP 1B1 to platelet-derived growth factor-BB-induced VSMC migration and proliferation in vitro and to neointimal growth in vivo. Methods and Results VSMC s isolated from aortas of male Cyp1b1 <sup>+/+</sup> and Cyp1b1 <sup>-/-</sup> mice were used for in vitro experiments. Moreover, carotid arteries of Cyp1b1 <sup>+/+</sup> and Cyp1b1 <sup>-/-</sup> mice were injured with a metal wire to assess neointimal growth after 14 days. Platelet-derived growth factor- BB -induced migration and proliferation and H<sub>2</sub>O<sub>2</sub> production were found to be attenuated in VSMC s from Cyp1b1 <sup>-/-</sup> mice and in VSMC s of Cyp1b1 <sup>+/+</sup> mice treated with 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl, a superoxide dismutase and catalase mimetic. In addition, wire injury resulted in neointimal growth, as indicated by increased intimal area, intima/media ratio, and percentage area of restenosis, as well as elastin disorganization and adventitial collagen deposition in carotid arteries of Cyp1b1 <sup>+/+</sup> mice, which were minimized in Cyp1b1 <sup>-/-</sup> mice. Wire injury also increased infiltration of inflammatory and immune cells, as indicated by expression of CD 68<sup>+</sup> macrophages and CD 3<sup>+</sup> T cells, respectively, in the injured arteries of Cyp1b1 <sup>+/+</sup> mice, but not Cyp1b1 <sup>-/-</sup> mice. Administration of 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl attenuated neointimal growth in wire-injured carotid arteries of Cyp1b1 <sup>+/+</sup> mice. Conclusions These data suggest that CYP 1B1-dependent oxidative stress contributes to the neointimal growth caused by wire injury of carotid arteries of male mice.
Evaluation of the nutritional status and tumor characteristics in premenopausal and postmenopausal breast cancer patients. (1998)

Evaluation of the nutritional status, fat tissue distribution, and tumor characteristics was carried out in patients with primary breast cancer. The patients were classified into two groups according to their menopause: premenopausal and postmenopausal. Breast cancer prevalence was considerably higher in postmenopausal patients (61%). The patients' nutritional status was shown through the body mass index. Based on this indicator, the patients were characterized as nonobese and obese. In the premenopausal group, there was no significant difference between these categories, whereas the number of obese patients was significantly higher (80%) in the postmenopausal group. The analysis of tumor parameters as related to menopause and body size did not yield any significant differences. However, the estrogen receptor content was significantly higher in postmenopausal patients (p < 0.0001). Distribution of fat tissue of the android type was higher in obese postmenopausal women than in premenopausal ones (77%). The investigation showed that the breast cancer incidence odds are 3.5 times higher in obese postmenopausal than in premenopausal patients.
Patient Health Status and Costs in Heart Failure (2009)

Health status assessment predicts resource use and costs over the next year in stable heart failure outpatients with left ventricular dysfunction after myocardial infarction.
FiberClay: Sculpting Three Dimensional Trajectories to Reveal Structural Insights (2018)

Visualizing 3D trajectories to extract insights about their similarities and spatial configuration is a critical task in several domains. Air traffic controllers for example deal with large quantities of aircrafts routes to optimize safety in airspace and neuroscientists attempt to understand neuronal pathways in the human brain by visualizing bundles of fibers from DTI images. Extracting insights from masses of 3D trajectories is challenging as the multiple three dimensional lines have complex geometries, may overlap, cross or even merge with each other, making it impossible to follow individual ones in dense areas. As trajectories are inherently spatial and three dimensional, we propose FiberClay: a system to display and interact with 3D trajectories in immersive environments. FiberClay renders a large quantity of trajectories in real time using GP-GPU techniques. FiberClay also introduces a new set of interactive techniques for composing complex queries in 3D space leveraging immersive environment controllers and user position. These techniques enable an analyst to select and compare sets of trajectories with specific geometries and data properties. We conclude by discussing insights found using FiberClay with domain experts in air traffic control and neurology.
Methods for Measurement of LDL-Cholesterol: A Critical Assessment of Direct Measurement by Homogeneous Assays versus Calculation (2002)

Available evidence supports recommending the homogeneous assays for LDL-C to supplement the Friedewald calculation in those cases where the calculation is known to be unreliable, e.g., triglycerides >4000 mg/L. Before the homogeneous assays can be confidently recommended to replace the calculation in routine practice, more evaluation is needed.
Protocol for the pig liver ischemia/reperfusion injury (2020)

<title>Abstract</title> Liver ischemia/reperfusion injury (IRI) is a dreadful vascular complication, which leads to liver damage. It is often associated with graft loss in liver transplantation and with a higher morbidity and mortality. IRI can have different causes, such as inflow clumping during surgical procedures in hepatic resection, liver transplantation, trauma, as well as during the stenosis of the vasculature caused by cancer. Here, we show a detailed IRI protocol in a porcine model.
Giant Cell Arteritis (2022)

Abstract This chapter discusses giant cell arteritis (GCA), which affects medium and large arteries and is the most common primary vasculitis in adulthood. This inflammatory arteritis has its onset almost always after age 50 years, and the highest incidence occurs in the seventh and eighth decades of life. Clinically, GCA may present in a variety of ways, but headache is the most common initial symptom. Additional findings include abnormalities of the temporal artery (beading, prominence, tenderness, and pulselessness), jaw claudication, scalp tenderness, tongue or scalp necrosis, diplopia, elevated erythrocyte sedimentation rate (ESR), and visual changes. GCA can also cause a rapidly sequential, bilateral blindness. If GCA is considered likely by clinical history and physical examination, a workup demonstrating elevations in ESR and C-reactive protein should be done. Corticosteroids are considered the preferred treatment of GCA. Tocilizumab, an interleukin-6 receptor blocker, has been shown to lessen total steroid dosage and duration of steroid treatment.
A Predicted α-Helix Mediates Targeting of the Proprotein Convertase PC1 to the Regulated Secretory Pathway (2000)

The proprotein convertase PC1 is a protease whose activity is largely confined to the dense core secretory granules of neuroendocrine cells. Efficient processing of PC1 substrates in granules requires a mechanism that will both limit the activity of the enzyme to these organelles and promote its targeting to the nascent secretory granules. In the current study, we provide evidence that targeting of PC1 to secretory granules is mediated by alpha-helical structures in its C-terminal tail and, at least in part, is dependent on interactions with specific components of the secretory granule membrane.
Interventions for Enhancing Adherence to Antiretroviral Therapy (ART): A Systematic Review of High Quality Studies (2015)

We sought to review the effectiveness of interventions designed to improve adherence to antiretroviral therapy (ART) from studies included in a recent Cochrane review that reported a clinical and an adherence outcome, with at least 80% follow-up for 6 months or more. Data were extracted independently and in duplicate, with an adjudicator for disagreements. Risk of bias was assessed using the Cochrane Risk of Bias tool. Of 182 relevant studies in the Cochrane review, 49 were related to ART. Statistical pooling was not warranted due to heterogeneity in interventions, participants, treatments, adherence measures and outcomes. Many studies had high risk of bias in elements of design and outcome ascertainment. Only 10 studies improved both adherence and clinical outcomes. These used the following interventions: adherence counselling (two studies); a once-daily regimen (compared to twice daily); text messaging; web-based cognitive behavioral intervention; face-to-face multi-session intensive behavioral interventions (two studies); contingency management; modified directly observed therapy; and nurse-delivered home visits combined with telephone calls. Patient-related adherence interventions were the most frequently tested. Uniform adherence measures and higher quality studies of younger populations are encouraged.
Some Aspects of the Zoom Transform (1976)

The spectral analysis of a long time series is often hampered by the limited capacity of the Fourier analyzer. The ideal frequency resolution of the analysis of N sample points cannot be realized if the analyzer cannot handle N points simultaneously. This paper examines some of the aspects of the zoom transform, which provides for partial recovery of the ideal resolution on an analyzer of limited capcity by concentrating the analysis on selected frequency bands.
Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity (2011)

Unlike metabolites of most drugs, the studied JWH-018 monohydroxylated compounds, but not the carboxy metabolite, retain in vitro and in vivo activity at CB1Rs. These observations, combined with higher CB1R affinity and activity relative to Δ(9)-THC, may contribute to the greater prevalence of adverse effects observed with JWH-018-containing products relative to cannabis.
3D Phase Retrieval with Computational Illumination (2015)

This talk will describe new methods for achieving 3D and high-resolution images in a commercial microscope with Fourier Ptychography related methods and a multi-slice approach. Using a combination of optical hardware and post-processing software, we achieve high-resolution gigapixel images in multiple depth planes with fast capture times.