gebhart/patrepeval huggingface dataset:
Bevacizumab Related Hypertension and Reversible Posterior Leukoencephalopathy Syndrome in Gynecologic Malignancies: A case Control Study (2011)

Background: Bevacizumab is increasingly being used in the treatment of gynecologic malignancies, but has significant side-effects including hypertension and reversible posterior leukoencephalopathy (RPLS), which must be recognized by the gynecologic oncologist. Methods: A 26-month institutional retrospective review of bevacizumab in the treatment of gynecologic malignancies. Patients were grouped according to whether they had bevacizumab-related hypertension (defined as at least a grade one hypertensive toxicity) or not. There were no differences in patient demographics between the groups. Risk factors for developing bevacizumab-related hypertension were assessed using t-tests, Wilcoxon rank sum test and Fisher’s exact test. Results: Our group has treated 45 patients with bevacizumab. Fifteen (33%) patients had a pre-existing diagnosis of hypertension, 12 (80%) of whom had at least one elevated blood pressure during treatment. The 30 (67%) patients who did not have a pre-existing diagnosis of hypertension still had a high incidence of bevacizumab-related elevated blood pressure (14, 47%). The majority of patients (26, 58%) had at least one therapy cycle complicated by hypertension. Patients who experienced bevacizumab-related hypertension were significantly more likely than not to have a history of hypertension (odds ratio of 4.6, 95% CI 1.1-19.6). There was a 4.4% incidence of reversible posterior leukoencephalopathy. Patients with age equal to or greater than 75 years, stage IV disease, and creatinine elevations greater than or equal to 1.4 mg/dL were significantly more likely to develop bevacizumab-related hypertension. Other factors such as numbers of prior chemotherapies, cycles of bevacizumab, BMI, cancer site, and histology were not significantly associated with bevacizumab-related hypertension. Conclusions: Hypertension is a problem for patients on bevacizumab whether or not they have a pre-existing diagnosis. However, those with a history of hypertension were significantly more likely to have bevacizumab-related hypertension.
Heterocyclic quinones. 4. A new highly cytotoxic drug: 6,7-bis(1-aziridinyl)-5,8-quinazolinedione (1983)

With the aim of obtaining new antitumoral agents, a series of 5,8-quinazolinediones was prepared. 5-Amino-6-methoxyquinazoline was oxidized by Fremy's salt to give 6-methoxy-5,8-quinazolinedione. Nucleophilic substitution reaction at C6, electrophilic substitution at C7, and synthesis of 7-amino-6-methoxy-5,8-quinazolinedione, the parent compound of streptonigrin, were studied. These compounds were tested for cytotoxic properties on L1210 leukemia cells in vitro. One of them, 6,7-bis(1-aziridinyl)-5,8-quinazolinedione, which exhibits a high cytotoxic activity (ID50 = 0.08 microM), was further screened in standard antitumor systems, including L1210 leukemia, P388 lymphocytic leukemia, sarcoma 180, and B16 melanocarcinoma. This drug gives a significant antitumoral effect on P388 leukemia but is inactive on other experimental models. Moreover, this compound was found to be highly mutagenic for Salmonella typhimurium TA98 and TA100 strains (Ames test), suggesting that DNA damage could be responsible for its cytotoxicity.
A Framework for Risk Assessment of Disposal of Contaminated Materials Treated by Solidification/Stabilization (1997)

Quantitative risk assessment is a tool used at hazardous waste sites to evaluate the need for treatment and to determine which control strategies should be implemented. A general approach to conducting quantitative risk assessments at contaminated sites is reviewed and a framework for applying it to evaluating risk associated with groundwater contamination by disposal of materials treated by solidification and stabilization is presented. This approach is based on a material balance around the disposal zone and the groundwater flowing past it. Two limiting cases are identified that can control the concentration of contaminant leaving the leaching zone. The first case occurs when the leachate flow past the solid is low and the contaminant concentration in the leachate can approach that in equilibrium with the pore water in the solid. The second case occurs when the flow past the solid is sufficiently large that the concentration of contaminant in the flow is low enough that the rate of leaching is not affected. For this case, the flux from the solid can be predicted by simple leach models. Examples of applying this framework to materials treated by solidification/stabilization are presented. Key words: Risk assessment; solidification/stabilization; hazardous waste; remediation
The Yamabe problem (1987)

Contents 1. Introduction 2. Geometric and analytic preliminaries 3. The model case: the sphere 4. The variational approach 5. Conformai normal coordinates 6. Stereographic projections 7. The test function estimate 8. General relativity 9. Analysis on asymptotically flat manifolds 10. The positive mass theorem 11. Solution of the Yamabe problem Appendix: Witten's proof Bibliography
Wide angle holographic video projection display (2021)

Holographic projection displays provide high diffraction efficiency. However, they have a limited projection angle. This work proposes a holographic projection display with a wide angle, which gives an image of size 306<i>m</i><i>m</i>×161<i>m</i><i>m</i> at 700 mm and reduced speckle noise. The solution uses single Fourier lens imaging with a frequency filter and hologram generation utilizing complex coding and nonparaxial diffraction. The experiment was performed with a 4K phase-only spatial light modulator (SLM) to prove the high efficiency of the developed numerical tools. Optical reconstruction shows high resolution and high image quality achieved from a single frame. Hence, displaying video at a full frame rate of the SLM is possible.
Application of a genetic algorithm to feature selection under full validation conditions and to outlier detection (1994)

Abstract Genetic algorithms have been proved to be a very efficient method in the feature selection problem. However, as for every other method, if the validation of the results is performed in an incomplete way, erroneous conclusions can be drawn. In this paper a development of a previous genetic algorithm is presented so that a full validation of the results can be obtained. Furthermore, this algorithm has been shown to perform very well also as an outlier detector, allowing easy identification of the presence of outliers even in cases where the ‘classical’ techniques fail.
Stimulation of GATA-2 as a mechanism of hydrogen peroxide suppression in hypoxia-induced erythropoietin gene expression (2001)

Hydrogen peroxide (H2O2) has previously been shown to inhibit the DNA binding activity of hypoxia inducible factor-1 (HIF-1), the accumulation of HIF-1alpha protein and erythropoietin (Epo) gene expression. Epo gene expression has been previously shown to be down-regulated through a GATA binding site at its promoter region. In this study, the effect of H2O2 on Epo gene expression under hypoxic conditions through a GATA transcription factor was investigated. Hypoxic induction was found to be inhibited upon the addition of H2O2, and this effect could be reversed through the addition of catalase. Hypoxic induction was found to be suppressed by co-transfection with a human GATA-2 cDNA expression plasmid. Transfection of Hep3B cells with a reporter gene bearing a mutation at the promoter GATA binding site was found to be only mildly affected by the addition of H2O2. Electrophoretic gel mobility shift assays (EMSAs), using the Epo promoter GATA site as a probe and the GATA-2 protein extracted from Hep3B cells, showed that addition of H2O2 enhanced the binding of GATA-2 while addition of catalase inhibited this binding. From these results, we conclude that H2O2 increases the binding activity of GATA-2 in a specific manner, thereby suppressing the activity of the Epo promoter and thus inhibiting Epo gene expression.
Millimeter-Wave and Infrared Multisensor Design and Signal Processing (1997)

From the Publisher:
Here's a practical, non-theoretical introduction to the principles, applications and benefits of multi-sensor technology used in smart weapon development, surveillance systems, and an increasing variety of non-military applications. This book provides a broad overview of MMW (millimeter-wave) and IR (infrared) sensor constraints, design principles, system alternatives and targeting applications, and is unique in its coverage of integrated MMW and IR multisensor design. 

Drawing on extensive professional experience in the design of fire-and-forget weapon systems, the author describes the operation, tradeoffs, clutter scenarios, performance measures, and signal processing techniques applicable to passive and active MMW and IR sensors. You learn how target detection, even in high-clutter background, and identification of atmospheric and land-based features can be greatly enhanced by combining data from selected multiple sensors.
Solar Cell Production Using UMG Silicon (2009)

Materials studies and solar cells made from various blends of UMG (Upgraded Metallurgical Grade) Silicon are compared with a reference Solar (PV) grade in terms of efficiencies, voltages, currents, diffusion lengths, minority carrier lifetimes and compositions. The UMG material used in this study performed unexpectedly well when used in cells manufactured both in a lab environment and on a commercial PV line. The limited number of cells of each composition does not support a full statistical analysis. However, in comparing solar efficiencies, it is clear that a relatively minor delta exists between UMG blends and the particular PV grade material used in this study. That delta is between zero and 0.5 percentage points. Preliminary, non-optimized gettering studies were also performed and indicate that it should be possible to improve the baseline UMG material with the goal of performance equivalent to PV grade. It is recognized that all UMG materials on the market are not identical and that material specifications have wide variation, if any exist at all from any particular material source. Results in this study could be different depending on where UMG material is obtained and its respective elemental and material analysis.
Widespread Severe Acute Respiratory Syndrome Coronavirus 2 Transmission Among Attendees at a Large Motorcycle Rally and their Contacts, 30 US Jurisdictions, August–September, 2020 (2021)

The 2020 Sturgis motorcycle rally resulted in widespread transmission of severe acute respiratory syndrome coronavirus 2 across the United States. At least 649 coronavirus disease 2019 cases were identified, including secondary and tertiary spread to close contacts. To limit transmission, persons attending events should be vaccinated or wear masks and practice physical distancing if unvaccinated. Persons with a known exposure should be managed according to their coronavirus disease 2019 vaccination or prior infection status and may include quarantine and coronavirus disease 2019 testing.
Novel system for generating cytotoxic effector lymphocytes using carcinoembryonic antigen (CEA) peptide and cultured dendritic cells. (2003)

We have established a practical system for generating antitumor effector lymphocytes using the tumor antigen peptide CEA and cultured dendritic cells (DCs), and have also characterized effector cells. DCs were induced from the adherent cell population of autologous peripheral blood mononuclear cells (PBMCs) obtained from HLA-A0201 normal or tumor-bearing donors using IL-4 and GM-CSF. The cultured DCs were shown to express class I, class II, CD80 and CD86 molecules. The PBMCs were stimulated for 7 days with the DCs pulsed with the HLA-A0201-restricted CEA peptide CEA9 671 and then expanded in an anti-CD3 antibody (1 microgram/ml)-coated flask in the presence of a 80 U/ml IL-2 (IL-2/CD3 system). The effector cells, which were designated as CEA peptide-pulsed dendritic cell-activated killer (CEA-PDAK) cells, were preferentially CD3+CD8+, and capable of killing T2 cells pulsed with CEA peptide but not T2 cells alone. The CA-PDAK cells also lysed the gastric cancer cell line KATO III (HLA-A0201, CEA (+)), but not the WiDr (HLA-A2402, CEA(+)) cells. The cytotoxicity was abrogated when the CEA-PDAK cells were treated with anti-TCR alpha beta antibody or when the target cells were treated with the anti-class I antibody prior to the cytotoxicity assay. The CEA-PDAK cells exerted their cytotoxic activity even in the presence of a high amount of CEA protein at the effector phase, which mimicked the clinical setting. The CEA-PDAK cells showed approximately a hundred-fold expansion in total cell numbers yielded without any loss of the specific lysis, when stimulated with the IL-2/CD3 system compared to those stimulated with IL-2 alone. The TCR V beta gene analysis for the CEA-PDAK cells, conducted by means of RT-PCR-Southern blotting, demonstrated oligoclonal expression of TCR beta 7 and 12, and the latter was shown to be responsible for the killing activity. SSCP analysis indicated the clonotype of the TCR V beta 12 gene, indicating a selective expansion of lymphocytes bearing a limited TCR variable region by the stimulation with CEA peptide-pulsed DCs. Taken together, the effector lymphocytes reactive with the CEA antigen can be generated from PBMCs with the antigenic CEA peptide and cultured DCs. The IL-2/CD3 system is effective and practical in activating the effector cells for the clinical use of CEA-PDAK cells. Adoptive immunotherapy using this system may be promising for treating CEA-expressing tumors.
"Architecture of a Video Web - Experience with Annodex" (2007)

Since the year 2000 a project under the name of Continuous Media CMWeb, has explored how to make video (and incidentally audio) a first class citizen on the Web. The project has led to a set of open specifications and open source implementations, which have been included into the Xiph set of open media technologies. In the spirit of the Web, specifications for a Video Web should be based on unencumbered formats, which is why Xiph was chosen.
Proactive mining system in potosi silver mines : new information from re-evaluation of historical materials regarding the fifth viceroy toledo's various policies on environment (2016)

In this paper, the proactive mining system introduced by the fifth viceroy, Francisco de Toledo (1569–1581) to the Potosi Silver Mine is clarified on the facts found in the historical documents. Main policies in Toledo’s mining business are followings, the application of mercury-amalgamation to extract silver from ores, the construction of the hydraulic-powered system for silver-ore crashing with cascading uses, the recycle system included the extraction of silver from waste ores and collection mercury by pulpprocessing. Also in the Toledo’s era, acceleration of developing Huancavelica mercury mine, and national monopolization and production control on mercury were established. And within Toledo’s mining law, there were cautionary items for pre¬venting the inhalation of mercury gas and the construction of hospitals for treatment. According to those items, the viceroy Toledo may be prominent organizer for business but because these were not technically perfect, environmental damages referred to now as mine pollution started from the colonial period and continued until modern-day period. This pollution can be found in Potosi’s air, water, and soil. The history of Potosi mine can’t be described leaving out the viceroy Toledo.
63 DISEASE-RELATED QUANTITATIVE ALTERATIONS IN MUC2 SYNTHESIS IN ULCERATIVE COLITIS ARE REGULATED AT THE TRANSLATIONAL LEVEL (1996)

Mucus covers and protects the colonic epithelium. Alterations in mucins, the structural molecules in mucus, may play a role in the pathogenesis of Ulcerative colitis (UC), a chronic disease that may find its onset at child age or in adults. We have demonstrated that, of the nine human mucins known to data, MUC2 is the prominent mucin in normal and UC colon and that the biosynthesis was qualitatively unchanged (KMAJ Tytgat et al., Gut 1996, in press). Aim of this study was to quantify MUC2 synthesis in UC at the mRNA and polypeptide level. Methods: Sigmoidal biopsies were collected from 7 controls, 6 patients with active UC and 6 with UC in remission (1 mnth-10 y). Two biopsies were metabolically labeled with [35S]amino acids. Two other biopsies were used for RNA isolation. Total protein quantity was measured and total incorporation of radioactivity into proteins was determined. Total RNA content was quantified by measuring A260nm. MUC2 mRNA was quantified using spot-blotting and a specific [32P]antisense MUC2 RNA probe and the activity was measured with a β-imager (arbitrary units, au). MUC2 mRNA levels were quantified as the ratio of MUC2 mRNA and total RNA. To quantify the MUC2 polypeptide biosynthesis, radioactively labeled homogenates were run on 3-10% SDS-PAGE gel. The radioactivity in the MUC2 precursor band was quantified using a β-imager (au). To quantify total MUC2 (precursor and mature), homogenates were spot-blotted and incubated with a specific anti-MUC2 antibody and 125l-labeled protein A and quantified using a β-imager (au). Viability of biopsies was determined as ratio between incorporated radioactivity and protein content. MUC2 precursor synthesis was quantitated as the ratio between MUC2 precursor and viability. Total MUC2 was quantitated as the ratio of total MUC2 and protein content. Results: [SEM indicated in brackets] MUC2 mRNA (×106 au/μg) was for controls 1.15 [0.18], for active UC 1.18 [0.10] and for UC in remission 1.30 [0.18]. Viability of biopsies (×104 dpm/mg) was for controls 353 (SEM 64), for active UC 427 [65] and for UC in remission 353 [81]. MUC2 polypeptide synthesis (au/(dpm/mg)) in controls was 5.19 [2.55], for active UC 3.27 [1.66] and for UC in remission 9.02 [1.97]. Total MUC2 quantity (×104 au/mg) was in 104 [17], for active UC 48 [8] and for UC in remission 131 [21]. Conclusions: Total MUC2 and MUC2 precursor biosynthesis are significantly decreased in active UC, but are significantly enhanced in UC in remission compared to controls. Since there are no significant differences between the patient populations at the MUC2 mRNA level, differences in MUC2 synthesis as result of UC are posttranscriptionally regulated. These disease-related alterations in MUC2 biosynthesis may have implications for the pathogenesis of UC.
Super Mirror (2012)

We propose the Super Mirror, a Kinect-based system that combines the functionality of studio mirrors and prescriptive images to provide the user with instructional feedback in real-time. In this study, we developed a working prototype of this system, which records ballet movements (also called positions and poses), captures live motion, and shows the difference between the two.
Ostwald ripening on the wall of a semi-infinite system (1996)

The Lifshitz-Slyozov-Wagner theory of Ostwald ripening describes the asymptotic ($t\ensuremath{\rightarrow}\ensuremath{\infty}$) diffusive growth of the condensate in a supersaturated solution. In the present work this theory is extended to a semi-infinite system where droplets of the condensate exist in the bulk as well as on the boundary wall. Both types of droplets interact with each other via the bulk diffusion field. We focus on the implications of this interaction for the growth of surface droplets which in the partial-wetting regime are spherical caps. It turns out that these droplets show a qualitatively different behavior for contact angles bigger or less than $\frac{\ensuremath{\pi}}{2}$. In the former case the droplets may initially grow but eventually shrink until the boundary wall becomes completely dry. The latter case is dominated by droplets which grow and eventually cover the whole wall. Within our model the growth rate of droplets with an arbitrary contact angle is calculated exactly.
On the use of EMI for the assessment of dental implant stability (2014)

The achievement and the maintenance of dental implant stability are prerequisites for the long-term success of the osseointegration process. Since implant stability occurs at different stages, it is clinically required to monitor an implant over time, i.e. between the surgery and the placement of the artificial tooth. In this framework, non-invasive tests able to assess the degree of osseointegration are necessary. In this paper, the electromechanical impedance (EMI) method is proposed to monitor the stability of dental implants. A 3D finite element model of a piezoceramic transducer (PZT) bonded to a dental implant placed into the bone was created, considering the presence of a bone-implant interface subjected to Young’s modulus change. The numerical model was validated experimentally by testing bovine bone samples. The EMI response of a PZT, bonded to the abutment screwed to implants inserted to the bone, was measured. To simulate the osseointegration process a pulp canal sealer was used to secure the implant to the bone. It was found that the PZT’s admittance is sensitive to the stiffness variation of the bone-implant interface. The results show that EMIbased method is able (i) to evaluate the material properties around the implant, and (ii) to promote a novel non-invasive monitoring of dental implant surgical procedure.
STUDY OF DISTRIBUTED RUNOFF SIMULATION MODEL BASED ON BLOCK TYPE TOPMODEL AND MUSKINGUM-CUNGE METHOD (1999)

The TOPMODEL is a physically based variable contributing area model of basin hydrology. It has two distinct advantages to be applied in developing areas with little hydrological observations. One is that it has both advantages of lumped model and distributed model, i. e., few parameters to be identified and the capability of simulating the impacts of land use changes and water resource system developments. The other is that the soil topographic index that the model greatly depends on may be easily identified through satellite information. In this paper, a distributed hydrological forecasting model by combining the block-wise application of the TOPMODEL with the Muskingum-Cunge flood routing method is proposed. The model is applied to the daily and hourly runoff simulation for the 3500km2 Fujikawa basin in Japan and to the daily simulation for the 19000 km2 sub-basin of Minjiang catchment in China. The results presented are encouraging to suggest that the proposed model is hopeful to be reasonably applied to large basins with DEM and other GIS oriented data.