gebhart/patrepeval huggingface dataset:
An evaluation of a research experience for teachers in nanotechnology (2017)

This study involves the evaluation of the second implementation of a Research Experiences for Teacher Advancement In Nanotechnology (RETAIN) program offered at Indiana University-Purdue University Indianapolis (IUPUI). RETAIN represents a professional development model for providing high school teachers with laboratory research experiences in nanoscience and related content areas. In this intensive summer program, teachers spend six weeks conducting nanotechnology-related research in an IUPUI lab. As part of the RETAIN program, teachers complete six credit hours of coursework, wherein they translate their research experiences into the design of classroom modules. Teachers are expected to then implement their modules within their own classrooms during the subsequent academic year. This evaluation focuses on teachers' experiences in IUPUI labs during the summer of 2016, along with three teachers' implementation of nanotechnology labs within their courses during the 2016–2017 school year. To evaluate RETAIN, we explored teacher satisfaction, changes in teachers' content knowledge and nanotechnology perceptions, as well as changes in teachers' epistemological beliefs. Further, we explored the impact of the three teachers' module integration on their students' STEM attitudes and nanotechnology perceptions. The findings indicated that teachers were generally satisfied with the research and course experiences. Further, as a result of RETAIN participation, teachers showed increased nanotechnology content knowledge and knowledge of nanotechnology-related careers. Lastly, three teachers' integration of nanotechnology modules indicated that their students had significantly improved perceptions of nanotechnology's potential coupled with more knowledge of nanotechnology-related careers. The paper concludes with considerations of the quantitative findings in light of teachers' written reflections and author observations of teacher module integration in their classrooms.
Author Correction: Retention of Mitochondria in Mature Human Red Blood Cells as the Result of Autophagy Impairment in Rett Syndrome (2021)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Histological assessment of non‐alcoholic fatty liver disease (2006)

Non-alcoholic fatty liver disease (NAFLD) is an important complication of the metabolic syndrome, which is becoming an increasingly common cause of chronic liver disease. Histological changes typically mainly affect perivenular regions of the liver parenchyma and include an overlapping spectrum of steatosis, steatohepatitis and persinusoidal or pericellular fibrosis, in some cases leading to cirrhosis. Once cirrhosis has developed, typical hepatocellular changes are often no longer conspicuous, leading to such cases being mistakenly diagnosed as 'cryptogenic'. Portal inflammation, ductular reaction and periportal fibrosis can also be seen as part of the morphological spectrum of NAFLD, particularly in the paediatric population. Hepatocellular carcinoma has also been described as a complication of NAFLD-associated cirrhosis. NAFLD is also an important cofactor in other chronic liver diseases, especially hepatitis C. Histological assessments have an important role to play in the diagnosis and management of NAFLD. These include making the potentially important distinction between simple steatosis and steatohepatitis and providing pointers to the aetiology, including cases where a dual pathology exists. A number of systems have been devised for grading and staging the severity of fatty liver disease. These require further evaluation, but have a potentially important role to play in determining prognosis and monitoring therapeutic responses.
On the Feasibility of Tailoring Copper–Nickel Functionally Graded Materials Fabricated through Laser Metal Deposition (2019)

In this study, pulse-width modulation of laser power was identified as a feasible means for varying the chemical gradient in copper–nickel-graded materials. Graded material deposits of 70 wt. %. copper-30 wt. %. nickel on 100 wt. %. nickel and vice versa were deposited and characterized. The 70/30 copper–nickel weight ratio in the feedstock powder was achieved through blending elemental copper and 96 wt. %. Ni–Delero-22 alloy. At the dissimilar material interface over the course of four layers, the duty cycle of power was ramped down from a high value to optimized deposition conditions. This change was theorized to influence the remelting and deposition height, and by extension, vary the chemistry gradient. X-ray Energy Dispersive Spectroscopy (EDS) analysis showed significant differences in the span and nature of chemistry gradient with varying duty cycles. These observations were also supported by the variation in microhardness values across the interface. The influence of different chemistry gradients on the tensile performance was observed through mini-tensile testing, coupled with Digital Image Correlation (DIC). The strain fields from the DIC analysis showed variations in strain for different chemistry gradients. The strength measurements from these specimens were also different for different chemistry gradients. The site of failure was observed to always occur within the copper-rich region.
Metal‐catalyzed lipid oxidation and changes of proteins in fish (1971)

Abstract The addition of metals to pure fats and model systems has given us a picture of the part they play in lipid oxidation. But in complex substrates such as fish flesh the same metal ions catalyze reactions in other components of the muscle as well. A more complete picture of deterioration is obtained when we also examine the effect of metals on the other components of the muscle. Although lean fish muscle contains 0.5% to 1% unsaturated lipids, during frozen storage it rarely goes rancid, as indicated by thiobarbituric acid (TBA) values or rancid odors. The lipids do oxidize, but instead of forming carbonyls and other compounds associated with rancidity, they become bound up in lipid‐protein complexes, which accounts for the toughened texture of overstored or poorly stored frozen fish. It has been generally accepted that the formation of these lipid‐protein polymers is brought about by a reaction between the proteins and oxidizing fatty acids. For fish of the gadoid or cod family, this is further complicated by the enzymic production of formaldehyde, which forms in the muscle during cold storage. The direct addition of formaldehyde to give concentrations of 0.001% to 0.05% caused marked reductions in the extractable protein of cod muscle. Because formaldehyde and dimethylamine (DMA) are produced in the stored muscle by the same reaction, the accumulation of the DMA can be used as a measure of this process which leads to protein insolubility. Removal of the dark lateral muscle from the fillets before freezing reduced the production of DMA and formaldehyde during storage and resulted in less loss of extractable protein.
Differential expression of matrix metalloproteinases and their tissue inhibitors at the advancing pterygium head. (2000)

Pterygia are a proliferative and inflammatory growth of limbal epithelial stem cell origin, characterized by corneal tissue invasion and extensive matrix remodeling including the destruction of Bowman's layer (BL). The purpose of this study was to determine the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) at the advancing pterygium edge.Formalin-fixed, paraffin-embedded whole eyes (n = 11) with pterygia attached, were serially sectioned and analyzed immunohistochemically to determine the spatial distribution of four MMPs and three TIMPs. Tear samples were collected from other patients with pterygia (n = 11) and displayed by gelatin zymography.Collagenase-1 was expressed by pterygium epithelial cells, corneal stromal fibroblasts and pterygium fibroblasts that had migrated between the epithelium and BL at the advancing pterygium edge. Collagenase-3 and gelatinases A and B were detected in all pterygia, intensely staining columnar epithelial cells directly adjacent to the denatured BL. In addition, gelatinase A immunoreactivity was observed on BL. Immunoreactivity for TIMP-1 and -3 paralleled that of the gelatinases, with more intense staining in epithelial cells and fibroblasts where BL was absent. TIMP-2 was faintly detected in pterygium epithelial cells but intensely stained pterygium fibroblasts. Gelatinase B was the most abundant gelatinolytic enzyme present in tears, elevated approximately twofold in eyes with pterygia versus the contralateral control eyes.This investigation is the first to identify the expression pattern of MMPs and TIMPs at the advancing pterygium edge in specimens of human eyes and in tears derived from patients with pterygia. These enzymes may be responsible for the destruction of BL, and their pattern of differential expression suggests that each may play a selective role in the pathogenesis of pterygia.
Monogamy equality in 2⊗2⊗d quantum systems (2008)

There is an interesting property about multipartite entanglement, called the monogamy of entanglement. The property can be shown by the monogamy inequality, called the Coffman–Kundu–Wootters inequality [Phys. Rev. A 61, 052306 (2000); Coffman–Kundu–WoottersPhys. Rev. Lett. 96, 220503 (2006)], and more explicitly by the monogamy equality in terms of the concurrence and the concurrence of assistance, CA(BC)2=CAB2+(CACa)2, in the three-qubit system. In this paper, we consider the monogamy equality in 2⊗2⊗d quantum systems. We show that CA(BC)=CAB if and only if CACa=0 and also show that if CA(BC)=CACa, then CAB=0, while there exists a state in a 2⊗2⊗d system such that CAB=0 but CA(BC)&amp;gt;CACa.
Behavioral changes and trigeminal ganglion sodium channel regulation in an orofacial neuropathic pain model (2005)

We used a photochemical method to generate a partial ischemic injury to the infraorbital branch of the trigeminal nerve in rats. Following injury, rats developed a bilateral persistent hypersensitivity to mechanical stimulation in the territory innervated by the infraorbital nerve. In addition, spread of mechanical hypersensitivity beyond the facial region was noted. Heat hypersensitivity was also present, although to a lesser extent and of a shorter duration. In some rats, excessive facial grooming/scratching were observed. Morphological examination revealed a graded damage to the irradiated portion of the infraorbital nerve that was related to the duration of laser irradiation. Investigations of gene expression changes in injured trigeminal ganglion neurons of animals with behavioral signs of neuropathic pain demonstrated that the sodium channel alpha-subunit Na(v)1.3-absent in sham-operated animals-was expressed to a limited extent. mRNAs for Na(v)1.8 and Na(v)1.9 were reduced both with respect to proportions of expressing neurons and to intensities, whereas the beta 3 subunit was markedly upregulated. mRNA levels of p11, a regulatory factor that facilitates the surface expression of Na(v)1.8, were unchanged. Previous findings have shown that injury to the trigeminal nerve branches may elicit responses that differ from those of segmental spinal nerves. Despite this we conclude that the key sodium channel regulations that are reported as consequences of nerve damage in the dorsal root ganglia seem to appear also in the trigeminal ganglion. Thus, novel analgesic drugs designed to target the sodium channel subtypes involved could be of use for the treatment of orofacial pain.
The Process of Performance Improvement: Preserving Myocardial Function (2001)

In today's healthcare environment, the continual assessment of processes is necessary to provide the best patient care. Ongoing process improvement also is helpful in organizations' remaining both competitive and fiscally viable. Because of the increasing concern about mortality rates from acute myocardial infarction (AMI), the Johnson City Medical Center chose to evaluate the care of patients with AMI. This article describes the first of three phases of the hospital's efforts to examine and improve the process of caring for patients with AMI to achieve positive patient outcomes.
On the Effects of Combined Atmospheric Fading and Misalignment on the Hybrid FSO/RF Transmission (2016)

Free-space optical (FSO) communication is known for its various impairments such as atmospheric turbulence and misalignment fading. In this paper, we study the performance of an FSO link operating under combined path loss and atmospheric and misalignment fadings. We derive a closed-form expression for the bit error rate (BER) of the FSO link in such conditions when the on–off keying (OOK) modulation is employed and when the fluctuations of the received signal are modeled by Gamma–Gamma distribution. In addition, we evaluate the effects of the combined fadings on the outage probability of the FSO link for different strengths of turbulence and pointing errors. Furthermore, we investigate the advantages of combining radio frequency (RF) with FSO to form hybrid FSO/RF systems. The RF link is based on 16 quadrature amplitude modulation (16-QAM) and on Rician channel fading. We study the performance of the hybrid FSO/RF system in terms of outage probability and BER and find that the hybrid FSO/RF system can overcome the weaknesses of FSO links, which are sensitive to atmospheric variations and misalignment fading.
Measurement of Energies Controlling Ripening and Annealing on Metal Surfaces (1998)

The successful experimental implementation of a powerful concept for the determination of energies controlling ripening and annealing on surfaces is reported. On a Ag(111) surface, we have prepared and studied the decay of well-defined nanostructures for which an available exact theoretical description can be used. The decay is followed by fast scanning tunneling microscopy at various temperatures to determine the 2D evaporation rate of atoms from island edges and the interlayer mass transport. An activation energy for 2D evaporation of $(0.71\ifmmode\pm\else\textpm\fi{}0.03)\phantom{\rule{0ex}{0ex}}\mathrm{eV}$ and an Ehrlich-Schwoebel barrier of $(0.13\ifmmode\pm\else\textpm\fi{}0.04)\phantom{\rule{0ex}{0ex}}\mathrm{eV}$ are determined.
Optimization and scale up of microfluidic nanolipomer production method for preclinical and potential clinical trials (2018)

In this study, we have demonstrated that a nanolipomer formulation can be successfully synthesized and easily scaled up through a high flow microfluidic system with optimal characteristics. The process of developing nanolipomers using this methodology is significant as the same optimized parameters used for small batches could be translated into manufacturing large scale batches for clinical trials through parallel flow systems.
A Review on Hydroponics and the Technologies Associated for Medium- and Small-Scale Operations (2022)

According to the Food and Agriculture Organization of the United Nations, the world population will reach nine billion people in 2050, of which 75% will live in urban settlements. One of the biggest challenges will be meeting the demand for food, as farmland is being lost to climate change, water scarcity, soil pollution, among other factors. In this context, hydroponics, an agricultural method that dispenses with soil, provides a viable alternative to address this problem. Although hydroponics has proven its effectiveness on a large scale, there are still challenges in implementing this technique on a small scale, specifically in urban and suburban settings. Also, in rural communities, where the availability of suitable technologies is scarce. Paradigms such as the Internet of Things and Industry 4.0, promote Precision Agriculture on a small scale, allowing the control of variables such as pH, electrical conductivity, temperature, among others, resulting in higher production and resource savings.
Design and Verification of Nearly Ideal Flow and Heat Transfer in a Rotating Disk Chemical Vapor Deposition Reactor (1991)

A research chemical vapor deposition reactor design is presented for a rotating disk configuration. The reactor can be operated under conditions such that nearly ideal, one‐dimensional, infinite‐radius disk behavior is achieved over most of the disk surface. Boundary conditions, flow stability under both isothermal and heated‐disk conditions, and gas temperatures are addressed with both one‐ and two‐dimensional numerical fluid mechanics models. Experimental verification of the design using flow visualization and laser Raman thermometry are presented.
Amperometric Detection of Glucose Released from Imune Lysis of Glusoce Loaded Liposome (1982)

Abstract Glucose released from complement mediated immuno-specific damage of glucose loaded lipososmes sensitized with lipid antigens was detected by an amperometric glucose enzyme electrode in view of devising a simple method for electrochemical immunoassay. This method involves the indirect determinatio of antibody and complement levels by measurement of the relesed glucose. The results were correlated with those obtained by the prevous spectrophotometric method with excellent accuracy, indicating that the amperometric enzyme electrode can be another substitute for the previous spectrophotometric detectin of glucose released from immune lysis of liposme loaded with glucose.
Paternal deletion 6q24.3: A new congenital anomaly syndrome associated with intrauterine growth failure, early developmental delay and characteristic facial appearance (2008)

Deletions of the long arm of chromosome 6 are relatively uncommon and to date minimal genotype-phenotype correlations have been observed. We report on three unrelated patients with de novo paternal interstitial deletions of 6q24.3. FISH mapping was used to delineate the minimal region of overlap between these three patients. Although all three patients had different size deletions and different breakpoints, two of the patients shared a 2.5 Mb region of overlap and strikingly similar facial features including a triangular face, frontal bossing with metopic prominence, short and upward-slanting palpebral fissures, asymmetry of upper eyelids, hooded eyelids, shallow orbits, prominent inferior orbital crease, wide mouth, and long and flat philtrum. They also had redundant skin, joint laxity, a small thorax, and early developmental delay. The smallest region of overlap between all three patients was a region of deletion less than 1 Mb; all had a history of IUGR and postnatal short stature without overt radiologic skeletal anomalies. The dysmorphic features, early developmental and growth delay may be due to the hemizygous state for one of the genes in the deleted region of two of the patients or to a long range effect of the deletion on expression of other genes. In addition, since imprinted genes have been reported in this region, paternal deletion of an imprinted gene in all three patients may contribute to the growth phenotype. We propose that this is a new congenital malformation syndrome associated with a paternal deletion of 6q24.3.
Protein–protein interaction prediction with deep learning: A comprehensive review (2022)

Most proteins perform their biological function by interacting with themselves or other molecules. Thus, one may obtain biological insights into protein functions, disease prevalence, and therapy development by identifying protein-protein interactions (PPI). However, finding the interacting and non-interacting protein pairs through experimental approaches is labour-intensive and time-consuming, owing to the variety of proteins. Hence, protein-protein interaction and protein-ligand binding problems have drawn attention in the fields of bioinformatics and computer-aided drug discovery. Deep learning methods paved the way for scientists to predict the 3-D structure of proteins from genomes, predict the functions and attributes of a protein, and modify and design new proteins to provide desired functions. This review focuses on recent deep learning methods applied to problems including predicting protein functions, protein-protein interaction and their sites, protein-ligand binding, and protein design.
Development of a New Burnishing Method Utilizing a Flank Face of a Turning Tool and its Burnishing Performance (2015)

As a measure to perform a burnishing process easily on an NC lathe, the authors propose a new method using a flank face positioned in a few millimeters lower part of the nose cutting edge of a tool. In the experiment, giving a fixed depth of burnishing (t=1, 2 and 4μm/pass), the carbon steel workpiece (S45C) of φ30mm which had been turned at V=200m/min and f=0.15mm/rev was burnished by predefined number of times. As a result, the surface roughness improved in nearly proportion to the total depth of burnishing and the roughness value of Rz≈10μm measured after turning could be improved to Rz≈2.5μm. Utilizing the feed control with an accuracy level of micron meters of the NC lathe, an attempt to control the dimensional accuracy of the workpiece diameter in the order of micron meters was also made. As a result, the workpiece radius came down constantly by 0.6~0.8 times in proportion to the tool depth of burnishing (t=1μm/pass), which reveals that the dimensional accuracy of the workpiece diameter could be controlled by the proposed burnishing process utilizing a fixed depth of burnishing system. Using the same burnishing process, circularity of the workpiece Δr could be improved to Δr≈2μm from Δr≈4μm measured after turning.
Characterization of Submicron Mechanical Properties of Al-Alloy Foam Using Nanoindentation Technique (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
ENHANCED TESTOSTERONE IN FEMALE PATIENTS WITH ANOREXIA NERVOSA: ITS NORMALIZATION AFTER WEIGHT GAIN (1979)

In order to elucidate the mechanism of disturbances of gonadal hormones secretion in anorexia nervosa 14 female patients were investigated. A control group also consisted of 14 women of the same age. The serum LH, progesterone, oestrogens: oestrone + oestradiol (Oe1 + Oe2), oestriol (Oe3) and testosterone were determined by radioimmunological methods. In patients with anorexia nervosa the serum testosterone and Oe3 concentrations were dramatically elevated, whereas LH, progesterone and Oe1 + Oe2 were decreased as compared with the control group. Considerable weight gain induced by cyproheptadine treatment caused a normalization of the serum testosterone and Oe3 concentrations in all the patients. A negative correlation between the testosterone level and the deficit in body weight was observed. The mechanism causing the dramatically high serum testosterone concentration in the female patients with anorexia nervosa is discussed.