gebhart/patrepeval huggingface dataset:
Re and Tc Complexes Containing B−H···M Agostic Interactions as Building Blocks for the Design of Radiopharmaceuticals (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTRe and Tc Complexes Containing B−H···M Agostic Interactions as Building Blocks for the Design of RadiopharmaceuticalsRaquel Garcia, António Paulo, Ângela Domingos, Isabel Santos, Kirstin Ortner, and Roger AlbertoView Author Information Departamento de Química, ITN,Estrada Nacional, 10 2686-953, Sacavém Codex, Portugal Institute of Inorganic Chemistry, University of Zürich Winterthurerstrasse 190, CH-8057 Zürich Cite this: J. Am. Chem. Soc. 2000, 122, 45, 11240–11241Publication Date (Web):October 27, 2000Publication History Received19 July 2000Published online27 October 2000Published inissue 1 November 2000https://pubs.acs.org/doi/10.1021/ja002652thttps://doi.org/10.1021/ja002652trapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views567Altmetric-Citations94LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Coordination chemistry,Imidazoles,Ligands,Nuclear medicine,Pharmaceuticals Get e-Alerts
Low Collagenase-1 (MMP-1) and MT1-MMP Expression Levels Are Favourable Survival Markers in Advanced Colorectal Carcinoma (2003)

&lt;i&gt;Objective:&lt;/i&gt; Extracellular matrix degradation is required for invasive growth and metastasis formation in colorectal carcinoma; therefore, we examined matrix metalloproteinases expression (MMP-1, MMP-13 and MT1-MMP) and apoptosis in tumours from 49 patients with advanced colorectal disease. &lt;i&gt;Methods:&lt;/i&gt; MMP expression was determined immunohistochemically and apoptotic index (AI) was ascertained using the TUNEL assay. &lt;i&gt;Results:&lt;/i&gt; Low levels of MT1-MMP, MMP-1 and AI were found to be favourable markers significantly associated with longer survival. MT1-MMP expression levels below the median (≤14.0% of tumour cells) were associated with better overall survival (median 26.2 vs. 15.6 months, p = 0.02) and MMP-1 expression levels below the median (≤28.7% of tumour cells) correlated with longer survival following metastasis (median 21.5 vs. 13.3 months, p = 0.05). MT1-MMP, MMP-1 and AI were all found to have significant independent effects on survival. Interestingly, MMP-1 expression levels above the median were associated with distal disease of the colon (p = 0.02). &lt;i&gt;Conclusions:&lt;/i&gt; These findings reveal that MT1-MMP and MMP-1 expression levels and AI are useful prognostic indicators in advanced colorectal carcinoma and suggest that markers of MMP expression might be used in identifying patients who would benefit from new treatment modalities involving MMP inhibitors.
Terminal complement complex formation is associated with intervertebral disc degeneration (2020)

TCC deposition positively correlated with the degree of disc degeneration. A functional relevance of TCC may exist in DD, representing a potential target for new therapeutics.
<title>Rock processing with CO<formula><inf><roman>2</roman></inf></formula> laser radiation</title> (1993)

The experimental processing of rocks shows the possibility and advantage of laser cutting especially for complicated shapes in plates to 25 - 30 mm thick. High productivity and good quality of cut surface make this technology competitive with traditional mechanical methods. Engraving with laser radiation is rapid and allows formation of clear images and pictures on rock surfaces. It enables the formation of decorative patterns of varying depth for volume images. Experimental results encourage the establishment of an industrial laser center for rock surface processing. The new generation of medium and high power rf excited diffusive cooled lasers are particularly suitable for this purpose.
A new fabrication technique for ultra-small diffusion-cooled hot-electron bolometers (1999)

Hot-electron bolometers (HEBs) are becoming the technology of choice for heterodyne mixing in the short submillimeter wavelength regime (frequencies above 1 THz). In this paper, we describe a new, versatile, easily variable method of diffusion-cooled HEB fabrication using a focused-ion beam (FIB) microscope. This technique does not require electron-beam lithography or definition of the bolometer element by lift-off.
Sequential Continuous Flow Processes for the Oxidation of Amines and Azides by using HOF⋅MeCN (2011)

The generation and use of the highly potent oxidising agent HOF·MeCN in a controlled single continuous flow process is described. Oxidations of amines and azides to corresponding nitrated systems by using fluorine gas, water and acetonitrile by sequential gas-liquid/liquid-liquid continuous flow procedures are reported.
Cryocooler cooled HTS current leads for a 1 MJ/1 MW-Class SMES system (2002)

Within the Italian project for the development of 1 MJ/1 MW SMES, Ansaldo-CRIS and CESI have been involved in the design and manufacturing of 1100 A resistive/HTS current leads conduction cooled by a closed cycle refrigerator. Main design and technological problems concern the achievement of electrical insulation between cryocooler and current leads at the voltage level of 6 kV together with a thermal contact good enough to keep the upper part of the HTS material at a temperature below 70 K, when the cryocooler temperature is 60 K and about 100 W is the thermal load. Thermal transport properties of electrical insulating materials as thin sheet placed between copper massive plates have been measured as a function of temperature and hence, according to the measured thermal performances, the area for thermal contact with the cryocooler has been suitably dimensioned. Mechanical structure for the whole current leads has been designed and manufactured. Final assembly of resistive section has been completed. Results about the achieved lead performances are presented and discussed.
Biconjugate gradient method for bistatic scattering calculations (1993)

Abstract It has recently been observed that the symmetric case of the biconjugate gradient method renders a variational formula for the monostatic scattering amplitude stationary in the available Krylov subspace at each iteration. In this Letter I point out that the general biconjugate gradient method makes stationary the analogous variational formula for a bistatic scattering amplitude and suggest likely practical benefits accruing from this property. © 1993 John Wiley &amp; Sons, Inc.
Assessment of viable conidia of Monilinia fructicola in flower and stone fruit combining propidium monoazide ( PMA ) and qPCR (2017)

Brown rot is the most economically important fungal disease of stone fruits and is primarily caused by Monilinia laxa and M. fructicola . Conventional methods used to identify M. fructicola are mainly based on phenotypic characteristics and pathogen quantification is not always accurate. In contrast, methodologies based on molecular tools improve pathogen characterization and identification but are not able to differentiate between live and dead conidia. In this study the PMA ‐ qPCR methodology was optimized, validated and applied to quantify viable cells of M. fructicola in artificially and naturally infected samples. qPCR methodology showed good primer efficiency and sensitivity with quantification limits lower than obtained using a plate count method. The conditions of propidium monoazide ( PMA ) pretreatment were 60 μ m PMA for 20 min incubation and 30 min of light‐emitting diode ( LED ) exposure that, combined with qPCR , measured live cells accurately without overestimation of dead cells. Using this methodology in naturally infected samples, M. fructicola live cells were quantified specifically, in contrast to other traditional methodologies that cannot distinguish among Monilinia spp. The developed methodology based on combined PMA ‐ qPCR will be a new tool to quantify viable M. fructicola in further epidemiological and ecological studies of this fungus.
Doped (Nb, Ta and V) titanium oxide as catalyst support for proton exchange membrane fuel cell (PEMFC) cathode (2015)

International audience
Secretory phospholipases A2 induce neurite outgrowth in PC12 cells (2003)

sPLA(2)s (secretory phospholipases A(2)) belong to a broad and structurally diverse family of enzymes that hydrolyse the sn -2 ester bond of glycerophospholipids. We previously showed that a secreted fungal 15 kDa protein, named p15, as well as its orthologue from Streptomyces coelicolor (named Scp15) induce neurite outgrowth in PC12 cells at nanomolar concentrations. We report here that both p15 and Scp15 are members of a newly identified group of fungal/bacterial sPLA(2)s. The phospholipid-hydrolysing activity of p15 is absolutely required for neurite outgrowth induction. Mutants with a reduced PLA(2) activity exhibited a comparable reduction in neurite-inducing activity, and the ability to induce neurites closely matched the capacity of various p15 forms to promote fatty acid release from live PC12 cells. A structurally divergent member of the sPLA(2) family, bee venom sPLA(2), also induced neurites in a phospholipase activity-dependent manner, and the same effect was elicited by mouse group V and X sPLA(2)s, but not by group IB and IIA sPLA(2)s. Lysophosphatidylcholine, but not other lysophospholipids, nor arachidonic acid, elicited neurite outgrowth in an L-type Ca(2+) channel activity-dependent manner. In addition, p15-induced neuritogenesis was unaffected by various inhibitors that block arachidonic acid conversion into bioactive eicosanoids. Altogether, these results delineate a novel, Ca(2+)- and lysophosphatidylcholine-dependent neurotrophin-like role of sPLA(2)s in the nervous system.
Margination of 2D Platelet Microparticles in Blood (2023)

Margination describes the movement of particles toward the endothelial wall within blood vessels. While there have been several studies tracking the margination of spherical particles in blood, the behavior of anisotropic particle shapes is not well described. In this study 2D platelet particles which possess many attractive qualities for use as a drug delivery system, with their high surface area allowing for increased surface binding activity, were directly monitored and margination quantified. The margination propensity of 1 and 2 μm 2D platelet particles was contrasted to that of 2 μm spherical particles at apparent wall shear rates (WSRs) of 50, 100, and 200 s<sup>-1</sup> by both directly tracking labeled particles using fluorescent microscopy as well as using small-angle X-ray scattering (SAXS). For fluorescence studies, margination was quantified using the margination parameter <i>M</i>, which describes the number of particles found closest to the walls of a microfluidic device, with an <i>M</i>-value of 0.2 indicating no margination. Increased margination was seen in 2D platelet particles when compared to spherical particles tested at all flow rates, with <i>M</i>-values of 0.39 and 0.31 seen for 1 and 2 μm 2D platelet particles, respectively, while 2 μm spherical particles had an <i>M</i>-value of 0.21. Similarly, margination was observed qualitatively using SAXS, with increased scattering seen for platelet particles near the microfluidic channel wall. For all particles, increased margination was seen at increasing shear rates.
Isoporous Block Copolymer Membranes (2014)

The developments in membranes based on tailored block copolymers are reported with an emphasis on isoporous membranes. These membranes can be prepared in different geometries, namely flat sheets and hollow fibers. They display narrow pore size distributions due to their formation by self-assembly. The preparation of these membranes and possibilities to further functionalize such membranes will be discussed. Different ways to control the pore size will be addressed, and the potential of block copolymer blends to fabricate membranes with tailored pore sizes will be shown.
Enhancing the Delivery of Resveratrol in Humans: If Low Bioavailability is the Problem, What is the Solution? (2014)

Resveratrol has emerged as a leading candidate for improving healthspan through potentially slowing the aging process and preventing chronic diseases. The poor bioavailability of resveratrol in humans has been a major concern for translating basic science findings into clinical utility. Although a number of positive findings have emerged from human clinical trials, there remain many conflicting results, which may partially be attributed to the dosing protocols used. A number of theoretical solutions have been developed to improve the bioavailability of resveratrol, including consumption with various foods, micronized powders, combining it with additional phytochemicals, controlled release devices, and nanotechnological formulations. While laboratory models indicate these approaches all have potential to improve bioavailability of resveratrol and optimize its clinical utility, there is surprisingly very little data regarding the bioavailability of resveratrol in humans. If bioavailability is indeed a limitation in the clinical utility of resveratrol, there is a need to further explore methods to optimize bioavailability in humans. This review summarizes the current bioavailability data, focusing on data from humans, and provides suggested directions for future research in this realm.
Imaging the local ideality factor by contactless photoluminescence measurement (2013)

A contactless method to image the local ideality factor of silicon wafers and silicon solar cells is introduced. The method is based on photoluminescence imaging and can be applied throughout the solar cell fabrication process, even before junction formation. The local ideality factor measured by the proposed method is found to be in good agreement with that measured by Suns-Voc. Examples of its application are given for fully and partially fabricated solar cells.
Chinese Keyword Extraction Based on N-Gram and Word Co-occurrence (2007)

This paper presents a new kind of Chinese text encoding method based on Chinese word, and establishes a new Chinese document format which deals with the automatic segmentation issue. This method makes word the smallest information unit. Chinese text analysis does not rely on segmentation by the method. On this word platform, N-gram and word co-occurrence statistical analysis are combined to carry out Chinese keyword extraction experiment. Firstly, candidate keywords are extracted with bi-gram model. Then, a set of co-occurrences between every word in bi-grams and frequent words is generated. Co-occurrence distribution shows importance of every word. According to the analysis result, keywords are chosen from bi-grams. This algorithm applies to a single document without using a corpus, and experimental results are satisfying.
[A multicenter study of epirubicin-docetaxel(ET)as primary chemotherapy for patients with inflammatory breast cancer(IBC)]. (2012)

We evaluated the efficacy and safety of the epirubicin plus docetaxel(ET)regimen, which is a combination of active agents given to patients with inflammatory breast cancer(IBC)as a primary therapy. Nineteen patients received ET(60, 60mg/m2) every 3 weeks for 4 courses, and appropriate surgery was offered unless disease progression occurred. Seventeen patients completed the ET regimen and 1 patient was excluded because of no diffuse erythema, leaving 18 patients evaluable for the response and safety profile of this regimen. Grade 3/4 hematological toxicities were neutropenia in 15 patients(79%), febrile neutropenia in 8 patients(42%)and anemia in 3 patients(16%). Six patients(63%)received granulocyte colony-stimulating factor for febrile neutropenia. Febrile neutropenia was observed only for 1 course in all 6 patients and progression to apparent infection was not observed. Grade 3/4 non-hematological toxicities were constipation in 3, nausea in 2, anorexia in 2, fatigue in 1, vomiting in 1, diarrhea in 1, and stomatitis in 1 patient. The ET regimen was given to 16 patients(89%)as planned. The median number of courses was 4(range: 2-4). The clinical response rate was 44%. The median time to progression was 9 months, and median overall survival was 26 months. It is concluded that the ET regimen was well tolerated and effective as a primary chemotherapy for IBC.
Increased adrenal androgen secretion with inhibition of 11β-hydroxylase in HIV-infected women (2005)

Adrenal androgen production is reduced in association with disease severity in HIV-infected women. This response may be maladaptive in terms of maintenance of lean body mass, functional status, and immune function. The aim of this study was to assess whether the use of an adrenal enzyme inhibitor of 11beta-hydroxylase might increase androgen production in this population. We conducted a randomized, double-blind, placebo-controlled study of metyrapone (500 mg p.o. qid) or placebo for 2 wk in 10 HIV-infected women with AIDS wasting [weight <90% ideal body weight (IBW) or weight loss >10%] and reduced androgen levels. Basal and ACTH-stimulated androgen, mineralocorticoid, and glucocorticoid levels were measured at baseline and after 14 days of treatment. Subjects were similar in age (40.9 +/- 0.9 yr), weight (91.7 +/- 3.5% IBW) and hormone concentrations at study entry. Total testosterone (84 +/- 54 vs. -0.4 +/- 2 ng/dl, P = 0.024), free testosterone (6.5 +/- 2.8 vs. 0.1 +/- 0.1 pg/ml, P = 0.024), DHEA (5.0 +/- 3.2 vs. -0.6 +/- 0.5 microg/l, P = 0.024), and 11-deoxycortisol (2,145 +/- 820 vs. -14 +/- 22 ng/dl, P = 0.024) levels increased in response to metyrapone compared with placebo treatment. In response to ACTH, significant increases in the DHEA/cortisol ratio (174 +/- 48 vs. 3 +/- 3, P = 0.008) were seen in the metyrapone group compared with placebo. Blood pressure and electrolytes did not change, and signs of adrenal insufficiency were not apparent. These data demonstrate that inhibition of 11beta-hydroxylase with metyrapone increases adrenal androgen secretion in HIV-infected women. Further studies are needed to assess the physiological effects of this strategy to increase anabolic hormone levels in severe stress, including detailed testing to rule out the potential risk of concomitant adrenal insufficiency.
Analysis and Test of a Proton Exchange Membrane Fuel Cell Power System for Space Power Applications (2000)

An effort is underway to develop a prototype Proton Exchange Membrane (PEM) Fuel Cell breadboard system for fuhlre space applications. This prototype will be used to develop a comprehensive design basis for a space-rated PEM fuel cell powerplant. The prototype system includes reactant pressure regulators, ejector-based reactant pumps, a 4-kW fuel cell stack and cooling system, and a passive, membranebased oxygen / water separator. A computer model is being developed concurrently to analytically predict fluid flow in the oxidant reactant system. Fuel cells have historically played an important role in human-rated spacecraft. The Gemini and Apollo spacecraft used fuel cells for vehicle electrical power. The Space Shuttle currently uses three Alkaline Fuel Cell Powerplants (AFCP) to generate all of the vehicle's 15-20kW electrical power. Engineers at the Johnson Space Center have leveraged off the development effort ongoing in the commercial arena to develop PEM fuel cel ls for terrestrial uses. The prototype design originated from efforts to develop a PEM fuel cell replacement for the current Space Shuttle AFCP' s. In order to improve on the life and an already excellent hi storical record of reliability and safety, three subsystems were focused on. These were the fuel cell stack itself, the reactant circulation devices, and reactant / product water separator. PEM fuel cell stack performance is already demonstrating the potential for greater than four times the useful life of the current Shuttle's AFCP. Reactant pumping for product water removal has historically been accomplished with mechanical pumps. Ejectors offer an effective means of reactant pumping as well as the potential for weight reduction, control simplification, and long life. Centrifugal water separation is used on the current AFCP. A passive, membrane-based water separator offers compatibility with the micro-gravity environment of space, and the potential for control simplification, elimination of moving parts in an oxygen environment, and long life. The prototype system has been assembled from components that have previously been tested and evaluated at the component level. Preliminary data obtained from tests performed with the prototype system, as well as other published data, has been used to validate the analytical component models. These components have been incorporated into an integrated oxidant fluid system model. Results obtained from both the performance tests and the analytical model are presented.
Unusual Rate Enhancement of Bimolecular Dehydrocondensation To Form Amides at the Interface of Micelles of Fatty Acid Salts (2005)

Die Grenzfläche Micelle/Wasser ist der geeignete Ort für Dehydrokondensationen. Entsprechend verlief die Kupplung von Fettsäuresalzen mit einem amphiphilen Triazin-Dehydrokondensationsagens im micellaren System (siehe Bild) bis zu 2000-mal schneller. Die Reaktionsbeschleunigung wird mit der höheren lokalen Konzentration und der Ausrichtung der Reaktanten in den Micellen erklärt.
Contemporary management of meconium ileus (1993)

Meconium ileus was noted as an early manifestation of cystic fibrosis in 60 neonates between 1972 and 1991. There were 20 girls and 40 boys. A family history of cystic fibrosis was present in six children. Twenty-five neonates had uncomplicated meconium ileus due to inspissated meconium within the terminal ileum. Thirty-five neonates presented with 56 complications of meconium ileus, including volvulus (n = 22), atresia (n = 20), perforation (n = 6), and giant cystic meconium peritonitis (n = 8). Clinical presentation included abdominal distension, bilious vomiting, and failure to pass meconium. In two recent cases, prenatal ultrasonography detected a mass with proximal bowel distension indicative of cystic meconium peritonitis. Mechanical bowel obstruction in the other neonates was diagnosed from plain abdominal radiographs and barium enema. Ten patients with uncomplicated meconium ileus were successfully treated with a diatrizoate meglumine (Gastrografin) enema. The remaining 15 patients required a laparotomy, with 9 treated by bowel resection and enterostomy and 6 recent cases managed with enterotomy and irrigation. Complicated cases were managed by bowel resection and anastomosis (n = 15) or enterostomy (n = 20). Survival at 1 year was 92% in patients with uncomplicated meconium ileus and 89% for those with complicated meconium ileus. The therapy of choice for uncomplicated meconium ileus is nonoperative Gastrografin enema, with enterotomy and irrigation reserved for enema failures. Complicated cases require exploration and, in the absence of giant cystic meconium peritonitis, are usually amenable to bowel resection and primary anastomosis.