gebhart/patrepeval huggingface dataset:
Death, Second (1992)

[Gk ho deuteros thanatos]. In the NT, the second death is mentioned only in Rev 2:11; 20:6, 14; and 21:8. It is symbolized as the “lake of fire” (20:14; 21:8), and presented as the opposite of receiving a crown of life (2:10) and life lived in the presence of God (21:3–7; 22:3–5). As opposed to the
Les femmes médecins aujourd'hui : l'avenir de la médecine ? (2014)

La féminisation de la médecine se poursuit avec une nette prédominance féminine chez les étudiants en médecine. Les femmes représentent 44 % des médecins en exercice avec des spécialités où elles sont majoritaires comme la médecine du travail ou la gynécologie médicale. Cependant certaines questions sont encore posées : pourquoi une telle prédominance masculine aux postes de responsabilités ? Les hommes sont-ils meilleurs que les femmes dans l’exercice de la médecine ? La féminisation de la médecine va-t-elle influer sur certaines spécialités ou certaines pratiques ? Qu’en est-il dans les autres pays ? Questions auxquelles nous tentons de répondre par notre vécu et notre cursus en tant que chefs de service dans un grand hôpital universitaire parisien.
T174. ANTIPSYCHOTICS AND THE MICROBIOME (2020)

Abstract Background Gut microbial diversity is influenced by many factors including aging and environmental factors and it has an important implication on various physiologic functions and disease processes. Studying microbial communities and its diversity may be used as a predictor or biomarker for disease development. Methods In-depth literature review was conducted of literature within the last 5 years via database search of Pubmed, PsycInfo, EMBASE, and Google Scholar with Boolean combinations of the following keywords: antipsychotics AND (microbiome OR “metabolic syndrome”), microbiome AND (gender OR aging). Results 2,360 articles were initially retrieved. 27 articles remained after excluding for non-English articles and relevance. Notable findings include that patients treated with both risperidone and olanzapine have less diverse microbiomes with a higher ratio of Firmicutes to Bacteroidetes. Additionally, patients treated with olanzapine have been shown to have increased actinobacteria and increased ratio of Firmicutes to Bacteroidetes. The ratio of Firmicutes to Bacteroidetes correlates directly to the extent of olanzapine induced weight gain. Patients concurrently treated with olanzapine and antibiotics not only stopped weight gain but also reversed it. This has been a target of potential medication intervention, specifically focused on antagonism of histamine-1 and -3 receptors which is speculated to inhibit the askewed Firmicutes to Bacteroidetes ratio. Similarly, the gender differences in relative microbiome levels of Bacteroidetes are suspected to correlate to the increased olanzapine induced weight gain seen in women versus men. Additionally, patients with schizophrenia who were treated with Bifidobacterium breve A1, a probiotic supplement, showed improvements in their affective, positive, and negative symptoms. Discussion There is a large paucity of research into the relationship between the microbiome and psychotropic medications. This dynamic should be further studied within multiple populations to better understand the gut biome’s effects on psychiatric disorders.
Accumulation of myeloid lineage cells is mapping out liver fibrosis post injury: a targetable lesion using Ketanserin (2018)

Liver fibrosis is problematic after persistent injury. However, little is known about its response to an acute insult. Accumulation of myeloid lineage cells contributes into the promotion and resolution of inflammation and fibrosis. Using Cre-transgenic mice that specifically mark myeloid lineage cells with EYFP and burn as a model of acute systemic injury, we investigated the role of myeloid lineage cells in the liver after acute injury. Our data show that thermal injury in mice (30% total body surface area) induces fibrosis predominantly around portal venules whereas myeloid cells are enriched throughout the liver. The fibrosis peaks around 1-2 weeks post injury and resolves by week 3. Ablating myeloid cells led to lower fibrosis. Through FACS sorting, we isolated myeloid lineage cells (EYFP +ve cells) from injured animals and from the control uninjured animals and subjected the extracted RNA from these cells to microarray analysis. Microarray analysis revealed an inflammatory signature for EYFP +ve cells isolated from injured animals in comparison with control cells. Moreover, it showed modulation of components of the serotonin (5-HT) pathway in myeloid cells. Antagonizing the 5HT<sub>2A/2C</sub> receptor decreased fibrosis in thermally injured mice by skewing macrophages away from their pro-fibrotic phenotype. Macrophages conditioned with Ketanserin showed a lower pro-fibrotic phenotype in a co-culture system with mesenchymal cells. There is a spatiotemporal pattern in liver fibrosis post-thermal injury, which is associated with the influx of myeloid cells. Treating mice with a 5HT<sub>2A/2C</sub> receptor antagonist promotes an anti-fibrotic effect, through modulating the phenotype of macrophages.
Applying Argumentation Schemes for Essay Scoring (2014)

Under the framework of the argumentation scheme theory Each annotation protocol defined argumentation schemes (i.e., reasoning patterns) in a given writing prompt and listed questions to help evaluate an argument based on these schemes, to make the argument structure in a text explicit and classifiable. We report findings based on an annotation of 600 essays. Most annotation categories were applied reliably by human annotators, and some categories significantly contributed to essay score. An NLP system to identify sentences containing scheme-relevant critical questions was developed based on the human annotations.
Characterization, design, modeling, and model validation of silicon on-wafer M:N balun components under match and un-matched conditions (2005)

In this paper, we characterize and model M:N baluns for RFIC design. A modeling methodology is presented, based on a scalable lumped-element approach that incorporates both skin effect and substrate loss. The impedance transformation characteristics of the scalable model are explored. The modeling approach is validated with measured S-parameters and extracted impedances from various circuit configurations. Matching considerations are addressed by evaluating the model accuracy with measured data under matched and un-matched conditions.
Estimating the Long-Term Effects of Storage at −70 °C on Cholesterol, Triglyceride, and HDL-Cholesterol Measurements in Stored Sera (2000)

We estimated the effects of long-term storage at -70 degrees C on serum total cholesterol, HDL-cholesterol, and triglycerides in specimens that had been stored for up to 7 years. These estimates were made using measurements in serial specimens collected from the placebo control group of the Air Force/Texas Coronary Atherosclerosis Prevention Study over a period of approximately 5 years. We compared the group means for pairs of serial specimens taken at 6- and 12-month intervals, assuming that (a) a negligible placebo effect occurred between the serial specimen pairs; (b) in the absence of storage effects, the variation in the group means would reflect only normal biological variation and would not materially affect the group means for the serial specimens; (c) any systematic changes in these group means would reflect storage-related changes; and (d) storage-related changes are cumulative, i.e., the overall changes for a given storage period are the sum of the changes during previous storage periods. We observed average decreases of 2.0% per year for total cholesterol over 7 years and 2.8% per year in triglycerides for the first 5 years. HDL-cholesterol decreased by 1.3% per year, but this change was not statistically significant. This approach may be useful for estimating storage-related changes for studies in specimens stored for a period of years and for which stability data may not be available.
Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown (2021)

<b>Objective:</b> To evaluate if the number of admitted extremely preterm (EP) infants (born before 28 weeks of gestational age) differed in the neonatal intensive care units (NICUs) of the SafeBoosC-III consortium during the global lockdown when compared to the corresponding time period in 2019. <b>Design:</b> This is a retrospective, observational study. Forty-six out of 79 NICUs (58%) from 17 countries participated. Principal investigators were asked to report the following information: (1) Total number of EP infant admissions to their NICU in the 3 months where the lockdown restrictions were most rigorous during the first phase of the COVID-19 pandemic, (2) Similar EP infant admissions in the corresponding 3 months of 2019, (3) the level of local restrictions during the lockdown period, and (4) the local impact of the COVID-19 lockdown on the everyday life of a pregnant woman. <b>Results:</b> The number of EP infant admissions during the first wave of the COVID-19 pandemic was 428 compared to 457 in the corresponding 3 months in 2019 (-6.6%, 95% CI -18.2 to +7.1%, <i>p</i> = 0.33). There were no statistically significant differences within individual geographic regions and no significant association between the level of lockdown restrictions and difference in the number of EP infant admissions. A <i>post-hoc</i> analysis based on data from the 46 NICUs found a decrease of 10.3%in the total number of NICU admissions (<i>n</i> = 7,499 in 2020 vs. <i>n</i> = 8,362 in 2019). <b>Conclusion:</b> This <i>ad hoc</i> study did not confirm previous reports of a major reduction in the number of extremely pretermbirths during the first phase of the COVID-19 pandemic. <b>Clinical Trial Registration:</b> ClinicalTrial.gov, identifier: NCT04527601 (registered August 26, 2020), https://clinicaltrials.gov/ct2/show/NCT04527601.
A Method for the Rapid Screening of Human Blod Samples for the Presence of HIV-1 Sequences: The Probe-Shift Assay (1989)

In theory, screening directly for the human immunodeficiency virus (HIV) DNA has advantages over screening for HIV-related antibodies; however, the HIV genome appears to be present only in a small fraction of peripheral blood cells from infected individuals. The polymerase chain reaction (PCR) specifically amplifies defined DNA segments, permitting the identification of specific DNA segments even if they are present in a fraction of cells. HIV-derived PCR-amplified segments have been detected by Southern transfer, "dot-blot" hybridization, and digestion with restriction endonucleases. Unfortunately, PCR may amplify not only the single segment of interest but also irrelevant segments, which can be incorrectly identified as HIV related. We describe here an alternative approach to specific detection of PCR-amplified DNA segments, the probe-shift assay, that is simpler, faster, and less subject to erroneous identification than the previously described techniques. The probe-shift assay relies on the hybridization of an appropriately labeled oligonucleotide probe to the amplified segment in solution. The hemiduplex formed between the amplified DNA and the probe is detected following fractionation on nondenaturing gels. This procedure is sufficiently sensitive to detect a single infected cell in the presence of more than 10(5) uninfected cells and has been applied directly to clinical samples.
Optics Market Overview and Future Opportunities (2017)

This presentation will give a brief overview of the current status of the optics market, and offer a vision for future opportunities. There is limited detailed market data on the optics market, but OSA Industrial Development Associates (OIDA) has made some general estimates through focused research about the market, which will be presented here. It will also point out some key characteristics of the optics market and give some examples of innovation in the market. The vision for the next opportunities will offer some “food for thought” for the panel and audience discussion.
Self-assembly of Peptide−Amphiphile C12−Aβ(11−17) into Nanofibrils (2009)

A peptide-amphiphile (C12-Abeta(11-17)) was constructed with a key fragment of amyloid beta-peptide (Abeta(11-17)) attached to dodecanoic acid through an amide bond. The self-assembly behavior of C12-Abeta(11-17) in aqueous solution is studied at 25 degrees C and at pH 3.0 and 10.0. Abeta(11-17) cannot form ordered self-assemblies. But C12-Abeta(11-17) exhibits a very strong ability to form ordered nanofibrils, and the specific fine structure of the nanofibrils can be modulated simply by adjusting the concentration or pH. The critical micelle concentration of C12-Abeta(11-17) was determined as 0.063 and 0.11 mM at pH 3.0 and 10.0, respectively, indicating a stronger assembling ability of C12-Abeta(11-17) at acidic pH. In 0.47 mM C12-Abeta(11-17) solution at pH 3.0, rodlike fibrils with a diameter of approximately 5 nm and varying length of hundreds of nanometers are observed. When the C12-Abeta(11-17) concentration increases to 1.87 mM at pH 3.0, the above rodlike fibrils pack in parallel and form tapelike fibrils through lateral association. In 1.87 mM C12-Abeta(11-17) solution at pH 10.0, twisted fibrils with regular periodicity of approximately 200 nm are formed by the twisting of approximately 20 nm wide and approximately 11 nm thick nanoribbons. The hydrophobic moiety is necessary in fibril formation, whereas the beta-sheet secondary structure of the peptide moiety plays an essential role in the twisting morphology. This work helps to understand the possible mechanism in amyloid fibrillogenesis and provides an approach to inscribe biological signals in self-assemblies with potential application in biomaterial fabrication.
Nanoscale Deformation Mechanisms in Bone (2005)

Deformation mechanisms in bone matrix at the nanoscale control its exceptional mechanical properties, but the detailed nature of these processes is as yet unknown. In situ tensile testing with synchrotron X-ray scattering allowed us to study directly and quantitatively the deformation mechanisms at the nanometer level. We find that bone deformation is not homogeneous but distributed between a tensile deformation of the fibrils and a shearing in the interfibrillar matrix between them.
<title>Preparations and properties of novel positive photosensitive polyimides</title> (1991)

Polyamic acid esters with phenol moieties (Ph-ES) were synthesized from diamines and dicarboxylic acids bonding to phenol moieties through ester linkage. To synthesize the dicarboxylic acids, 1 mol of BTDA was reacted with 2 mol of m-hydroxybenzyl alcohol in NMP. The resultant dicarboxylic acid are predominantly benzyl esters, not phenyl esters, was condensed with ODA, using DCC as condensing agent. The polyimide precursors Ph-ES was actually soluble in basic aqueous solutions. However, its dissolution rate was too low for binder resins used for resists. To increase the resist dissolution rate, polyamic acid PA, which is assumed to be more soluble in the base developer, was added to Ph-ES. The PA was synthesized from BTDA and ODA. Resists containing Ph-ES (60 wt%), PA (20 wt%) and naphthoquinone diazide (20 wt%) gave 4 micron line and space pattern with 5 micron thickness. There was no pattern deformation, even after the polyamic acid ester was heated at 320 degree(s)C to form the polyimides. The PA content was critical to the high resolution achievement. As the content of the PA to Ph-ES increases, the pattern shape of the resist deteriorated rapidly. At more than 40 wt% PA rate, patterns could not be obtained, because fine patterns peeled off form the silicon wafer substrate during the development. This proved that adjusting dissolution rates in basic aqueous solutions is one of the significant points for realizing fine resist patterns.
The Modified Oja-RLS Algorithm, Stochastic Convergence Analysis and Application for Image Compression (1998)

The results of theoretical analysis for stochastic convergence of the modified Oja-RLS learning rule are presented. The rule is used to find Karhunen Loeve Transform. Based on this algorithm, an image compression scheme is developed by combining approximated 2D KLT transform and JPEG standard quantization and entropy coding stages. Though 2D KLT transform is of higher complexity than 2D DCT, the resulting PSNR quality of reconstructed images is better even by 2[dB].
ChemInform Abstract: Preparation of L‐(Phosphonodifluoromethyl)phenylalanine Derivatives as Non‐Hydrolyzable Mimetics of O‐Phosphotyrosine. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Studies on Chemical Carcinogens. VI. Reductions of 3-and 8-Substituted 4-Nitroquinoline 1-Oxides (1968)

Reductions of 3-and 8-substituted 4-nitroquinoline 1-oxides with H2/Pd-C3 NaBH4, and phenylhydrazine were examined. These compounds were proved to be easily deoxygenated to produce the corresponding 4-hydroxyaminoquinolines in contrast to the fact that many other substituted 4-nitroquinoline 1-oxides were reduced to 4-hydroxyaminoquinoline 1-oxides under the same reduction conditions. These reductive behaviors were discussed in connection with the polarographic reduction potentials and the carcinogenic activity of these compounds.
Implementing conservation easements (1988)

THE Farmers Home Administration was given two new, rather unique assignments under the conservation category by the 1985 Food Security Act. Both involve easements for conservation purposes, one relating to farm property that we own, or will own, as we take into inventory farmland from FmHA borrowers and the other dealing with property owned by our borrowers who need to have their farm debt restructured so they can remain in business.

The program concerning our farm inventory property is in place; the other is not.

The inventory program 

FmHA's farm inventory unfortunately has grown in recent years, just as it has with other agricultural lenders. At FmHA, we now hold title to around 5,300 farm properties totaling about 1.6 million acres. While valuations remain in flux-and seemingly on the up-tick-the value of that property is estimated to be about $800 million.

Our policy is to sell that property as quickly as possible because it is expensive to maintain and because …
Inheriting Shame: The Story of Eugenics and Racism in America (2000)

How could so many of America's educational, political and intellectual leaders have advocated such things as institutionalization, segregation and even sterilization of those with inferior blood? How could the racist notion of selective breeding and racial betterment have become an integral part of high school and college biology textbooks? In this work Stephen Selden tells the story of the eugenics movement in America during the early decades of the 20th century. Complete with archival photographs, Inheriting Shame provides a powerful historical account and refutation of biological determinist ideas. Selden discusses the role played by America's foremost socialists and scientists, popular media, and most importantly, the school textbook, in shaping public consciousness regarding the truth of biological determinism. Much more than simply an historical overview, Inheriting Shame concludes with a trenchant analysis of contemporary research evidence of the role that inheritance plays in complex human behaviour - including traits ranging from Down Syndrome to violent behaviour and homosexuality.
THE USE OF A FACTORIAL DESIGN TO EVALUATE THE PHYSICAL STABILITY OF TABLETS PREPARED BY DIRECT COMPRESSION .2. SELECTION OF EXCIPIENTS SUITABLE FOR USE UNDER TROPICAL STORAGE-CONDITIONS (1991)

A factorial design has been used to study the influence of disintegrant concentration, storage temperature and relative humidity upon storage on the physical stability of tablets prepared by direct compression. Tablets prepared from a binary mixture of a filler-binder and a disintegrant were stored at different conditions. The ratios of the tablet parameters after storage to the initial parameters (Storage to Initial Ratio:SIR) of the crushing strength and the disintegration time were calculated and used as dependent variables. Filler-binders used were alpha-lactose monohydrate, beta-lactose and dicalcium phosphate dihydrate. Disintegrants (corn, potato, rice and tapioca starch, sodium starch glycolate and crospovidone) were added in a high and in a low concentration. With aid of multiple linear regression, the influence of three adjustable variables (disintegrant concentration, storage temperature and storage relative humidity) on the storage to initial ratio of the tablet parameters was calculated. A selection was made as to which excipients are least influenced by storage conditions and can be used in tablet formulations for tropical countries
Unified Load-Independent ZPA Analysis and Design in CC and CV Modes of Higher Order Resonant Circuits for WPT Systems (2019)

This article proposes a general unified methodology for arbitrary higher order resonant circuits. With the proposed methodology, the equivalent circuits and the general resonant methods of the higher order resonant circuit are presented to realize the load-independent constant current (CC) and constant voltage (CV) outputs at two different load-independent zero phase angle (ZPA) frequencies. In addition, the corresponding regularized mathematical models of the constant output current and voltage and the purely resistive input impedances in CC and CV output modes are derived. All compensation topologies in both inductive and capacitive power transfer (CPT) systems have the essence of higher order resonant circuits. It means that the proposed methodology can be applied to investigate the load-independent output and input characteristics of any inductive power transfer (IPT) and CPT topologies. A 3.3-kW LCC -series-compensated IPT system for electric vehicles (EVs) was designed and manufactured to verify the theoretical analysis. The system operating frequencies in both the CC output with ZPA and the CV output with ZPA are in compliance with the SAE J2954 standard.
Serogroup B Meningococcal Disease Vaccine Recommendations at a University, New Jersey, USA, 2016 (2017)

In response to a university-based serogroup B meningococcal disease outbreak, the serogroup B meningococcal vaccine Trumenba was recommended for students, a rare instance in which a specific vaccine brand was recommended. This outbreak highlights the challenges of using molecular and immunologic data to inform real-time response.
Hypertension in Obese Black Women is Not Caused by Increased Sympathetic Vascular Tone (2017)

These findings suggest that sympathetic activity does not contribute to hypertension in obese black women and provide further evidence for racial differences in hypertension mechanisms.