gebhart/patrepeval huggingface dataset:
The oral manifestations of Apert syndrome. (1992)

As part of an ongoing study of 119 patients with the Apert syndrome, extensive data were available for the analysis of oral manifestations, including mouth shape, lip posture, palatal morphology, dental anomalies, and malocclusion. Findings included a characteristic trapezoidal-shaped mouth. Cleft soft palate or bifid uvula was found in approximately 75%. A Byzantine-arch shaped palate was recorded in almost all patients. Dental anomalies included severely delayed eruption, ectopic eruption, and shovel-shaped incisors. Malocclusion tended to be severe with mesial molar occlusion, mandibular overjet, anterior and posterior crossbites, and severe crowding of teeth. The oral manifestations of Apert syndrome are compared and contrasted with those of Crouzon syndrome.
Complications of 1303 Central Venous Cannulations (1997)

Central venous catheterization (CVC), now a common procedure, has several major complications. We assessed their incidence in a prospective study of 1303 cannulations done in the intensive care unit or operating theatre. Chest radiographs were obtained to verify proper catheter placement and to detect pneumothorax. Complications were arterial puncture in 68 (5.2%) patients, arrhythmias in 21 (1.6%), cardiopulmonary arrest in 1 (0.1%), and pneumothorax in 5 (0.5%). The tip of the CVC was incorrectly located in 149 (11.2%). The chest radiograph was a valuable method for detecting complications of central venous catheterization.
Performance of time and frequency compression of faster-than-nyquist signaling in frequency-selective fading channels (2015)

This paper investigates the block error rate (BLER) performance of time and frequency domain compression for Faster-than-Nyquist (FTN) signaling in frequency-selective fading channels. In this paper, we use FTN mapping method in which FTN symbols are mapped onto orthogonal frequency division multiplexing (OFDM)/offset quadrature amplitude modulation (OQAM) symbol positions at a transmitter and a turbo soft interference canceller (SIC) used for an antenna-diversity receiver. Computer simulation results show that frequency domain compression decreases the required average received signal-to-noise power ratio satisfying the target average BLER compared to time domain compression when the root mean square (r.m.s.) delay spread is longer than approximately 1.5 μs. We also show, however, that the FTN signaling with time domain compression achieves a higher frequency efficiency compared to that with frequency domain compression when the r.m.s. delay spread is less than 1.5 μs.
Abstract WMP5: How Do Clinical Trial Exclusion Criteria Impact The Inclusivity Of Clinical Trials? (2023)

Intro: Enrolling women and under-represented minorities into clinical trials is a top priority for the stroke community. Common trial exclusions for medical conditions or demographics may negatively impact enrollment for these groups. We sought to describe the potential impact that various exclusion criteria have on trial eligibility of ischemic stroke (IS) patients by race and sex within the large, biracial Greater Cincinnati/Northern Kentucky Stroke Study (GCNKSS) population. Methods: The GCNKSS is a population-based study of 1.3 million people living in a 5-county area of southern Ohio/ Northern Kentucky. During 7/1/14-12/31/15 for blacks, and 2015 for whites, we captured all hospitalized ischemic strokes by screening ICD-9 codes 430-436 and ICD10 codes I60-I68, and G45-46. Commonly used exclusion criteria from stroke clinical trials were applied to the GCNKSS IS population, and were compared by sex and race. All comparisons were evaluated with chi-square test and corrected for multiple comparisons, as necessary. Results: In 2014-2015, there were 2806 ischemic stroke patients, which were 53% female, and 30% black. Table 1 presents common clinical trial exclusion criteria and the % excluded among IS patients, stratified by sex and race. Every trial exclusion evaluated had significant differences by sex, race, or both. Discussion: Within our population, we found that commonly-used age and disability clinical trial exclusion criteria exclude more women than men, and exclusion of milder strokes affects more men than women. Blood pressure, renal function, and early arrival time criteria exclude more blacks than whites, while older age exclude more whites than blacks. Optimal clinical trial design should be informed by epidemiology data to ensure representation of underrepresented populations in clinical trials. We will continue to provide epidemiology feedback on acute trial exclusion criteria to NIH StrokeNet proposals in the future.
Efficient single phase harmonics elimination method for microgrids operating in grid connected or standalone mode (2013)

A strategy to eliminate harmonics from the grid current as well as the voltage of the point of common coupling (PCC) for microgrid applications is presented in this paper. The position of the harmonics reduction unit is selected so that it can reduce the harmonics level of the grid current and PCC voltage harmonics irrespective of the distribution of the renewable energy sources in microgrid. The proposed compensation system can be operated in both grid connected and islanded microgrid system without changing any configuration. In the proposed control algorithm, the required amount of attenuation for the harmonics is determined to meet the THD requirement specified by IEEE 519. Fast and efficient algorithm for phase detection irrespective of the presence of harmonics has been utilized for the system. The effectiveness of proposed method is verified by simulation and experimental results.
A statistics-based reconstruction of high-resolution global terrestrial climate for the last 800,000 years (2021)

Curated global climate data have been generated from climate model outputs for the last 120,000 years, whereas reconstructions going back even further have been lacking due to the high computational cost of climate simulations. Here, we present a statistically-derived global terrestrial climate dataset for every 1,000 years of the last 800,000 years. It is based on a set of linear regressions between 72 existing HadCM3 climate simulations of the last 120,000 years and external forcings consisting of CO<sub>2</sub>, orbital parameters, and land type. The estimated climatologies were interpolated to 0.5° resolution and bias-corrected using present-day climate. The data compare well with the original HadCM3 simulations and with long-term proxy records. Our dataset includes monthly temperature, precipitation, cloud cover, and 17 bioclimatic variables. In addition, we derived net primary productivity and global biome distributions using the BIOME4 vegetation model. The data are a relevant source for different research areas, such as archaeology or ecology, to study the long-term effect of glacial-interglacial climate cycles for periods beyond the last 120,000 years.
A Transfer Learning Approach for Automated Segmentation of Prostate Whole Gland and Transition Zone in Diffusion Weighted MRI (2019)

The segmentation of prostate whole gland and transition zone in Diffusion Weighted MRI (DWI) are the first step in designing computer-aided detection algorithms for prostate cancer. However, variations in MRI acquisition parameters and scanner manufacturing result in different appearances of prostate tissue in the images. Convolutional neural networks (CNNs) which have shown to be successful in various medical image analysis tasks including segmentation are typically sensitive to the variations in imaging parameters. This sensitivity leads to poor segmentation performance of CNNs trained on a source cohort and tested on a target cohort from a different scanner and hence, it limits the applicability of CNNs for cross-cohort training and testing. Contouring prostate whole gland and transition zone in DWI images are time-consuming and expensive. Thus, it is important to enable CNNs pretrained on images of source domain, to segment images of target domain with minimum requirement for manual segmentation of images from the target domain. In this work, we propose a transfer learning method based on a modified U-net architecture and loss function, for segmentation of prostate whole gland and transition zone in DWIs using a CNN pretrained on a source dataset and tested on the target dataset. We explore the effect of the size of subset of target dataset used for fine-tuning the pre-trained CNN on the overall segmentation accuracy. Our results show that with a fine-tuning data as few as 30 patients from the target domain, the proposed transfer learning-based algorithm can reach dice score coefficient of 0.80 for both prostate whole gland and transition zone segmentation. Using a fine-tuning data of 115 patients from the target domain, dice score coefficient of 0.85 and 0.84 are achieved for segmentation of whole gland and transition zone, respectively, in the target domain.
Hypophysectomy techniques in treating metastatic carcinoma of the breast (1978)

This paper developes further the connections between linear systems and convolution equations. Here the emphasis is on equations on finite intervals. For these equations a new characteristic matrix (or operator) function is introduced, which contains all the important information about the equations and the corresponding operators. Explicit formulas for solutions and resolvent kernels are obtained. Convolution equations on the full line are also analyzed. Analogous results are derived for the inversion of finite and infinite Toeplitz matrices.
Setting Mechanisms of an Acidic Premixed Calcium Phosphate Cement (2013)

Premixed calcium phosphate cements (pCPC), where glycerol is used instead of water as mixing liquid, present better handling characteristics than water-based cements. However, the setting mechanisms of pCPC have not been described thoroughly. The aim of this paper is to increase the understanding of the setting mechanism of pCPC. The investigated cement starts to set when glycerol is exchanged with water via diffusion of glycerol out to the surrounding body fluid and water into the material. To better understand the water-glycerol exchange a method was developed where the setting depth of the cement was measured over time. Thermo gravimetric analysis (TGA) was used to determine the liquid exchange rate during setting. To study the influence of temperature on the crystalline end product, pCPC and water-mixed calcium phosphate cement (wCPC) were set at different temperatures and analyzed with X-ray diffraction (XRD). The setting depth measurements showed that the set layer of the pCPC grew with a speed proportional to t0.51 at 37°C. TGA results furthermore showed that less than 10% of the glycerol remained after 16 hours. Setting of pCPC at different temperatures showed that mainly brushite was formed at 5°C, a mixture of brushite and monetite at 21°C and mainly monetite at 37°C. It furthermore showed that brushite was the main phase after setting of wCPC, but some monetite was present in these cements. The study presents a new method for evaluation of pCPC that increases the understanding of their setting mechanism. Furthermore, the XRD results indicate that storage at 5°C could improve the shelf life of acidic pCPC.
Discordance between Fetal RhD Typing Using Molecular Methods and Neonatal Typing with Serology (1999)

Polymerase chain reaction (PCR)-based genotyping on amniotic fluid in an RhD-negative alloimmunized woman predicted an RhD-negative fetal blood type. The neonate was RhD-positive and developed hemolytic disease. Discrepant results were also observed on paternal testing. PCR analysis with a different set of primers correctly predicted the RhD-positive fetal and paternal blood type. Use of more than one set of primers and parental testing can avoid some of the problems associated with use of PCR genotyping.
1H, 13C NMR, X‐ray and conformational studies of new 1‐alkyl‐3‐benzoyl‐pyrazole and 1‐alkyl‐3‐benzoyl‐pyrazoline derivatives (2008)

The (1)H and (13)C NMR resonances of 22 1-alkyl-pyrazole and 25 1-alkyl-pyrazoline derivatives were assigned completely using the concerted application of one- and two-dimensional experiments (DEPT, gs-HMQC and gs-HMBC). Nuclear Overhauser enhancement (NOE) effects, conformational analysis and X-ray crystallography confirm the preferred conformation of those compounds.
Photodynamic therapy in combating the causative microorganisms from endodontic infections (2014)

Photodynamic therapy (PDT) is presented as a promising antimicrobial therapy that can eliminate microorganisms present in endodontic infections. This treatment is based on the use of a nontoxic photosensitizing agent followed by irradiation of a resonant light source being capable of generating highly reactive species that are harmful to microorganisms. The purpose of this paper is to review the dental literature about the main factors that encompass the use of PDT combined with endodontic treatment for decontamination of the root canal system. A literature search was performed using the following index databases: PubMed, ISI Web of Knowledge and MedLine, between 2000 and 2014, looking for studies regarding antimicrobial action of PDT and its application to endodontic therapy. It was observed that despite numerous promising results, it is still necessary to establish different parameters so that PDT can be used with maximum effectiveness in eliminating microorganisms that cause endodontic infections.
Safe and protected execution for the Morph/AMRM reconfigurable processor (2003)

Technology scaling of CMOS processes brings relatively faster transistors (gates) and slower interconnects (wires), making viable the addition of reconfigurability to increase performance. In the Morph/AMRM system we are exploring the addition of reconfigurable logic, deeply integrated with the processor core, employing the reconfigurability to manage the cache, datapath, and pipeline resources more effectively. However, integration of reconfigurable logic introduces significant protection and safety challenges for microprocess execution. We analyze the protection structures in a state of the art microprocessor core (R10000), identifying the few critical logic blocks and demonstrating that the majority of the logic in the processor core can be safely reconfigured. Subsequently, we propose a protection architecture for the Morph/AMRM reconfigurable processor which enable nearly the full range of power of reconfigurability in the processor core while requiring only a small number of fixed logic features which to ensure safe, protected multiprocess execution.
Stereoregularity of poly(isopropyl acrylate) and its racemization during hydrolysis (1972)

Abstract The diad tacticity of poly(isopropyl acrylate) was measured from the β‐proton absorptions of poly(isopropyl acrylate‐α,β‐ d 2 ) obtained with a 100 MHz NMR spectrometer, and temperature dependence of the tacticity of the polymers obtained by radical polymerization was determined. Enthalpy and entropy differences between isotactic and syndiotactic addition for poly(isopropyl acrylate) were calculated to give the following values: Δ(Δ S ) = 0.7 eu; Δ(Δ H ) = 0.51 kcal/mole. In the hydrolysis of poly(isopropyl acrylate‐α,β‐ d 2 ), it was found that the rate of hydrolysis of poly(isopropyl acrylate) was dependent on the molecular weight rather than on the tacticity. As for the rate of racemization during hydrolysis, the rate for syndiotactic polymer was much faster than that for the isotactic polymer. The exchange reaction of deuterium at α‐position with hydrogen occurred in all the polymers during hydrolysis reaction.
Drinking Water Nitrate and the Risk of Non-Hodgkinʼs Lymphoma (1996)

The increasing incidence of non-Hodgkin's lymphoma (NHL) in the United States is only partially explained by known risk factors. Nitrate is a contaminant of drinking water in many rural areas. We evaluated its association with NHL after accounting for dietary nitrate intake. For 156 cases and 527 controls who used Nebraska community supplies, average nitrate exposure was estimated from 1947 through 1979. Longterm consumption of community water with average nitrate levels in the highest quartile (> or = 4 mg per liter nitrate-nitrogen) was positively associated with risk [odds ratio (OR) = 2.0; 95% confidence interval (CI) = 1.1-3.6]. Dietary nitrate, which came mainly from vegetables, was not associated with NHL risk, after adjusting for vitamin C and carotene intakes. Persons with a lower intake of vitamin C were at slightly higher risk of developing NHL than persons whose daily intake was > or = 130 mg, for all levels of intake of drinking water nitrate; our findings were similar for the combined effect of water nitrate and carotene intake. Nitrate levels in private wells were measured at the time of the interview for 51 cases and 150 controls but were not associated with the risk of NHL after adjusting for pesticide use on the farm. These findings indicate that longterm exposure to elevated nitrate levels in drinking water may contribute to the risk of NHL.
Immunohistological patterns of myeloid antigens: tissue distribution of CD13, CD14, CD16, CD31, CD36, CD65, CD66 and CD67 (1993)

A number of differentiation antigens on myeloid cells have been defined on the CD classification system by the four International Workshops on Human Leucocyte Differentiation Antigens. The distribution of eight of these antigens (CD13, CD14, CD16, CD31, CD36, CD65, CD66, CD67) have been studied in human tissues, with the aim of documenting their immunohistological patterns and their degree of myeloid restriction. CD13, the most widely distributed antigen, was found in skin, bile canaliculi, kidney and pancreas. CD14 was not restricted to monocytes and tissue macrophages, being also strongly expressed on dendritic reticulum cells. CD16 was expressed on granulocytes and tissue macrophages (alveolar and Kupffer cells) and in the red pulp of the spleen. CD31 and CD36 gave a characteristic staining of vascular endothelium, corresponding to their identification as the platelet glycoproteins gp IIa and gp IV. Antibodies against the most recently defined myeloid antigens (CD65, CD66 and CD67) appeared to be more specific for myeloid differentiation than previously described 'myeloid antigens'.
Robotics in Arthroplasty (2020)

If one enters "robotics" and "joint replacement" in any search engine of the internet, an impressive number of links to very recent articles is presented Obviously, this is a current topic of high interest to -well -to whom -surgeons, industry, health care and have a CNC device executing the plan is standard knowledge of everybody in the business nowadays and the gold standard of production. A couple years later I started my surgical carrier in orthopedics and was stunned to see that everybody was doing such important cuts on a patients one and only left or right whatever
Amorphous Molybdenum Phosphide Nanoparticles for Electrocatalytic Hydrogen Evolution (2014)

Amorphous molybdenum phosphide (MoP) nanoparticles have been synthesized and characterized as electrocatalysts for the hydrogen-evolution reaction (HER) in 0.50 M H2SO4 (pH 0.3). Amorphous MoP nanoparticles (having diameters of 4.2 ± 0.5 nm) formed upon heating Mo(CO)6 and trioctylphosphine in squalane at 320 °C, and the nanoparticles remained amorphous after heating at 450 °C in H2(5%)/Ar(95%) to remove the surface ligands. At mass loadings of 1 mg cm–2, MoP/Ti electrodes exhibited overpotentials of −90 and −105 mV (−110 and −140 mV without iR correction) at current densities of −10 and −20 mA cm–2, respectively. These HER overpotentials remained nearly constant over 500 cyclic voltammetric sweeps and 18 h of galvanostatic testing, indicating stability in acidic media under operating conditions. Amorphous MoP nanoparticles are therefore among the most active known molybdenum-based HER systems and are part of a growing family of active, acid-stable, non-noble-metal HER catalysts.
Cerebrospinal fluid hypersecretion in pediatric hydrocephalus (2016)

Hydrocephalus, despite its heterogeneous causes, is ultimately a disease of disordered CSF homeostasis that results in pathological expansion of the cerebral ventricles. Our current understanding of the pathophysiology of hydrocephalus is inadequate but evolving. Over this past century, the majority of hydrocephalus cases has been explained by functional or anatomical obstructions to bulk CSF flow. More recently, hydrodynamic models of hydrocephalus have emphasized the role of abnormal intracranial pulsations in disease pathogenesis. Here, the authors review the molecular mechanisms of CSF secretion by the choroid plexus epithelium, the most efficient and actively secreting epithelium in the human body, and provide experimental and clinical evidence for the role of increased CSF production in hydrocephalus. Although the choroid plexus epithelium might have only an indirect influence on the pathogenesis of many types of pediatric hydrocephalus, the ability to modify CSF secretion with drugs newer than acetazolamide or furosemide would be an invaluable component of future therapies to alleviate permanent shunt dependence. Investigation into the human genetics of developmental hydrocephalus and choroid plexus hyperplasia, and the molecular physiology of the ion channels and transporters responsible for CSF secretion, might yield novel targets that could be exploited for pharmacotherapeutic intervention.
Many-to-many invocation: A New framework for building collaborative applications in ad hoc networks (2002)

Many-to-Many Invocation (M2MI) is a new paradigm for building collaborative systems that run in wireless proximal ad hoc networks of fixed and mobile computing devices. M2MI is useful for building a broad range of systems, including service discovery frameworks; groupware for mobile ad hoc collaboration; systems involving networked devices (printers, cameras, sensors); and collaborative middleware systems. M2MI provides an object oriented method call abstraction based on broadcasting. An M2MI invocation means ``Every object out there that implements this interface, call this method.&amp;apos;&amp;apos;. M2MI is layered on top of a new messaging protocol, the Many-to-Many Protocol (M2MP), which broadcasts messages to all nearby devices using the wireless network&amp;apos;s inherent broadcast nature instead of routing messages from device to device. In an M2MI-based system, central servers are not required; network administration is not required; complicated, resource-consuming ad hoc routing protocols are not required; and system development and deployment are simplified.
The pseudo-marginal approach for efficient Monte Carlo computations (2009)

We introduce a powerful and flexible MCMC algorithm for stochastic simulation. The method builds on a pseudo-marginal method originally introduced in [Genetics 164 (2003) 1139–1160], showing how algorithms which are approximations to an idealized marginal algorithm, can share the same marginal stationary distribution as the idealized method. Theoretical results are given describing the convergence properties of the proposed method, and simple numerical examples are given to illustrate the promising empirical characteristics of the technique. Interesting comparisons with a more obvious, but inexact, Monte Carlo approximation to the marginal algorithm, are also given.
A Low Phase Noise, Wide Tuning Range 20GHz Magnetic-Coupled Hartley-VCO in a 28nm CMOS Technology (2019)

A low phase noise, wide tuning range 20GHz magnetic-coupled Hartley-VCO fabricated in a 28nm CMOS technology is presented and targeted for 77/79GHz radar applications. The VCO is designed and optimized for low phase noise and large frequency tuning range by using a Hartley-VCO architecture. A wide tuning range of 2.2GHz and a best phase noise of -113.8dBc/Hz@1MHz have been achieved. To the best of authors' knowledge, this is the best VCO phase noise presented in an advanced CMOS technology. Furthermore, the VCO shows an excellent pushing performance of less than ± 80 MHz $/V$ due to the implemented current source on top of the VCO core. The VCO core has an area of 0.038 mm $^{2}$ and consumes 50mA from a 1.8V supply.