gebhart/patrepeval huggingface dataset:
Genetic algorithm optimization of the hole-drilling method for non-uniform residual stress fields (2008)

The hole-drilling method, coupled with the influence functions method, is a versatile technique for measuring residual stresses. The latter determines a relationship between residual stress and measured relaxed strains for any experimental configuration and material. However, several parameters which describe the functional basis for the residual stress must be defined. This paper presents a procedure, based on the least squares method and genetic algorithms, optimally to choose these parameters to reduce the effects of noise and uncertainty in experimental measurements. The performance of the method was tested against finite element simulations for typical applications such as shot peening, showing that the method is flexible and accurate and allows the reconstruction of residual stress at deeper positions than other techniques.
Stromal Claudin14-Heterozygosity, but Not Deletion, Increases Tumour Blood Leakage without Affecting Tumour Growth (2013)

The maintenance of endothelial cell-cell junctions is vital for the control of blood vessel leakage and is known to be important in the growth and maturation of new blood vessels during angiogenesis. Here we have investigated the role of a tight junction molecule, Claudin 14, in tumour blood vessel leakage, angiogenesis and tumour growth. Using syngeneic tumour models our results showed that genetic ablation of Claudin 14 was not sufficient to affect tumour blood vessel morphology or function. However, and surprisingly, Claudin 14-heterozygous mice displayed several blood vessel-related phenotypes including: disruption of ZO-1-positive cell-cell junctions in tumour blood vessels; abnormal distribution of basement membrane laminin around tumour blood vessels; increased intratumoural leakage and decreased intratumoural hypoxia. Additionally, although total numbers of tumour blood vessels were increased in Claudin 14-heterozygous mice, and in VEGF-stimulated angiogenesis ex vivo, the number of lumenated vessels was not changed between genotypes and this correlated with no difference in syngeneic tumour growth between wild-type, Claudin 14-heterozygous and Claudin 14-null mice. Lastly, Claudin 14-heterozygosity, but not complete deficiency, also enhanced endothelial cell proliferation significantly. These data establish a new role for Claudin 14 in the regulation of tumour blood vessel integrity and angiogenesis that is evident only after the partial loss of this molecule in Claudin 14-heterozyous mice but not in Claudin 14-null mice.
(Keynote) Issues and Challenges for Implementation of Large-Scale Energy Storage in Australia (2013)

The importance of energy storage for a renewable energy future, has been recognised since the oil crisis of the late 1970s, but despite a growing uptake of renewable energy technologies in recent decades, a global market for storage technologies has yet to emerge. Australia has a strong record of research and development of renewable energy technologies and storage, but a very poor record for commercialisation. This paper explores some of the issues and challenges being experienced by developers of energy storage technologies, particularly in Australia.
Interference with Gsα-Coupled Receptor Signaling in Renin-Producing Cells Leads to Renal Endothelial Damage (2017)

Intracellular cAMP, the production of which is catalyzed by the <i>α</i>-subunit of the stimulatory G protein (Gs<i>α</i>), controls renin synthesis and release by juxtaglomerular (JG) cells of the kidney, but may also have relevance for the physiologic integrity of the kidney. To investigate this possibility, we generated mice with inducible knockout of Gs<i>α</i> in JG cells and monitored them for 6 months after induction at 6 weeks of age. The knockout mapped exclusively to the JG cells of the Gs<i>α</i>-deficient animals. Progressive albuminuria occurred in Gs<i>α</i>-deficient mice. Compared with controls expressing wild-type Gs<i>α</i> alleles, the Gs<i>α</i>-deficient mice had enlarged glomeruli with mesangial expansion, injury, and FSGS at study end. Ultrastructurally, the glomerular filtration barrier of the Gs<i>α</i>-deficient animals featured endothelial gaps, thickened basement membrane, and fibrin-like intraluminal deposits, which are classic signs of thrombotic microangiopathy. Additionally, we found endothelial damage in peritubular capillaries and vasa recta. Because deficiency of vascular endothelial growth factor (VEGF) results in thrombotic microangiopathy, we addressed the possibility that Gs<i>α</i> knockout may result in impaired VEGF production. We detected VEGF expression in JG cells of control mice, and cAMP agonists regulated VEGF expression in cultured renin-producing cells. Our data demonstrate that Gs<i>α</i> deficiency in JG cells of adult mice results in kidney injury, and suggest that JG cells are critically involved in the maintenance and protection of the renal microvascular endothelium.
De l’exacerbation du moi dans la transmission de la vie (2015)

En 1898, Freud écrivait : « Ce serait théoriquement l’un des plus grands triomphes de l’humanité, l’une des libérations les plus tangibles à l’égard de la contrainte naturelle à laquelle est soumise notre espèce, si l’on pouvait élever l’acte de la procréation au rang d’une action volontaire et intentionnelle, et le dégager de son intrication avec la satisfaction d’un besoin naturel. » En ce début de xxie siècle, le vœu de Freud s’est réalisé. Grâce à la contraception et à la médicalisation d...
国際学会のための話す英語(9)化学式の説明 (1998)

<i>Microcystis aeruginosa</i> is a bloom-forming cyanobacterium found in freshwater environments. The draft genomes of the <i>M. aeruginosa</i> strains NIES-3787, NIES-3804, NIES-3806, and NIES-3807, which were isolated from Lake Kasumigaura, Japan, were sequenced. The genome sizes of NIES-3787, NIES-3804, NIES-3806, and NIES-3807 were 4,524,637, 4,522,701, 4,370,004, and 4,378,226 bp, respectively.
Desipramine: an overview. (1984)

It is proposed that factors including a long "track record," perceived lack of anticholinergic effects, suggestions of earlier onset of action, and the concept of noradrenergic specificity have contributed to the widespread clinical use of desipramine. Recent studies bearing on these clinical beliefs are reviewed, with a focus on desipramine side effects, specificity, and speed of onset as compared to other tricyclics and to new generation antidepressants.
Using multi-channel intracavity ECGs in a cross-validation procedure to estimate myocardial infarction (2002)

The objective of this study was to evaluate the ability of intracavity electrocardiograms (ECGs) to determine the presence of acute myocardial infarction in canines. Intracavity potentials were obtained from a cylindrical probe, 45 mm*10 mm in size, introduced into the left ventricular cavity through the left atrium. The probe has 40 evenly spaced unipolar electrodes on its surface. Intracavity potentials were recorded before and after myocardial infarction in six dogs. Evaluation of 480 normal and 480 post-infarct intracavity waveforms was based on the QRS area, ST segment area, maximum potential, and maximum negative dV/dt. Maximum negative dV/dt, the best one-dimensional classifier, was combined with each of the other three variables in a two-dimensional cross-validation procedure. Maximum negative dV/dt and maximum potential correctly identified 86% of the normal recordings and 87% of the post-infarct recordings. Maximum negative dV/dt and QRS areas classified 84% of the normal and 82% of the post-infarct waveforms correctly. Maximum negative dV/dt and ST segment area correctly identified 85% and 82% of the normal and post-infarct recordings, respectively.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Preferential Siting of Aluminum Heteroatoms in the Zeolite Catalyst Al‐SSZ‐70 (2019)

Abstract The adsorption and reaction properties of heterogeneous zeolite catalysts (e.g. for catalytic cracking of petroleum, partial oxidation of natural gas) depend strongly on the types and distributions of Al heteroatoms in the aluminosilicate frameworks. The origins of these properties have been challenging to discern, owing in part to the structural complexity of aluminosilicate zeolites. Herein, combined solid‐state NMR and synchrotron X‐ray powder diffraction analyses show the Al atoms locate preferentially in certain framework sites in the zeolite catalyst Al‐SSZ‐70. Through‐covalent‐bond 2D 27 Al{ 29 Si} J‐correlation NMR spectra allow distinct framework Al sites to be identified and their relative occupancies quantified. The analyses show that 94 % of the Al atoms are located at the surfaces of the large‐pore interlayer channels of Al‐SSZ‐70, while only 6 % are in the sub‐nm intralayer channels. The selective siting of Al atoms accounts for the reaction properties of catalysts derived from SSZ‐70.
Reversibly Cross-Linked Polyplexes Enable Cancer-Targeted Gene Delivery via Self-Promoted DNA Release and Self-Diminished Toxicity (2015)

Polycations often suffer from the irreconcilable inconsistency between transfection efficiency and toxicity. Polymers with high molecular weight (MW) and cationic charge feature potent gene delivery capabilities, while in the meantime suffer from strong chemotoxicity, restricted intracellular DNA release, and low stability in vivo. To address these critical challenges, we herein developed pH-responsive, reversibly cross-linked, polyetheleneimine (PEI)-based polyplexes coated with hyaluronic acid (HA) for the effective and targeted gene delivery to cancer cells. Low-MW PEI was cross-linked with the ketal-containing linker, and the obtained high-MW analogue afforded potent gene delivery capabilities during transfection, while rapidly degraded into low-MW segments upon acid treatment in the endosomes, which promoted intracellular DNA release and reduced material toxicity. HA coating of the polyplexes shielded the surface positive charges to enhance their stability under physiological condition and simultaneously reduced the toxicity. Additionally, HA coating allowed active targeting to cancer cells to potentiate the transfection efficiencies in cancer cells in vitro and in vivo. This study therefore provides an effective approach to overcome the efficiency-toxicity inconsistence of nonviral vectors, which contributes insights into the design strategy of effective and safe vectors for cancer gene therapy.
Excavating proteoglycan structure-function relationships: modern approaches to capture the interactions of ancient biomolecules (2022)

Proteoglycans are now well regarded as key facilitators of cell biology. Although a majority of their interactions and functions are attributed to the decorating glycosaminoglycan chains, there is a growing appreciation for the roles of the proteoglycan core protein and for considering proteoglycans as replete protein-glycan conjugates. This appreciation, seeded by early work in proteoglycan biology, is now being advanced and exalted by modern approaches in chemical glycobiology. In this review, we discuss up-and-coming methods to unearth the fine-scale architecture of proteoglycans that modulate their functions and interactions. Crucial to these efforts is the production of chemically defined materials, including semisynthetic proteoglycans and the in situ capture of interacting proteins. Together, the integration of chemical biology approaches promises to expedite the dissection of the structural heterogeneity of proteoglycans and deliver refined insight into their functions.
Modeling a Porous Intercalation Electrode with Two Characteristic Particle Sizes (1997)

A mathematical model of a complete cell containing a porous intercalation electrode with two characteristic particle sizes is presented. Galvanostatic cycling and relaxation phenomena on open‐circuit are compared to a cell with a single particle size. Electrodes with a particle‐size distribution show modestly inferior capacity‐rate behavior in all cases considered in this work. The cycling results exhibit a mismatch in the states‐of‐charge of the surfaces of the different particle sizes located at the same position in the electrode. The magnitude of this mismatch correlates with the slope of the open‐circuit potential vs. state‐of‐charge curve of the intercalation material. The relaxation on open circuit is substantially faster when the particles are uniformly sized. Asymptotic solutions were developed to aid in the description of the open‐circuit behavior in the cases with nonuniform particle sizes. The particle‐size distribution has a more pronounced influence on the open‐circuit results than on the galvanostatic results.
Exporting Knowledge Bases into OWL. (2006)

Abstract. We present our experience in exporting a knowledge base (KB). Specifically, we discuss the translations of the representation of scalar, cardinal, and categorical values, tasks, built-in data types, and collections. These examples could be illustrative for others trying to use OWL in their work. We also raise design questions that could provide fodder for discussion at the workshop. 1
THE ROLE OF NITRIC OXIDE IN OBSTRUCTIVE NEPHROPATHY (2000)

Inducible nitric oxide synthase knockout mice with unilateral ureteral obstruction have significantly lower nitrite in serum and urine than wild-type C57 mice. Knockout mice also have more severe renal cortical thinning than C57 animals after creation of unilateral ureteral obstruction. Providing L-arginine supplemented water to inducible nitric oxide synthase knockout mice exacerbates the loss of cortical thickness. Alterations in cortical thinning that we observed in knockout mice were associated with decreased tubulointerstitial fibrosis and a decreased net renal extracellular matrix accumulation. These data indicate that endothelial or neuronal nitric oxide synthase may be more important than inducible nitric oxide synthase for modulating renal fibrosis in obstructive uropathy.
Cyclopropanringöffnung an 3α,5‐Cyclo‐Steroid‐Kohlenwasserstoffen (1979)

Abstract An den 3α,5‐Cyclo‐Steroiden 4a–c erfolgt unter Einwirkung von gasförmigem Chlorwasserstoff in Chloroform bei −60°C Cyclopropanringöffnung unter stereoselektiver Bildung der Chloride 5a–c , die durch basisches Aluminiumoxid zu den 3‐Methyl‐A‐nor‐Derivaten 6a–c dehydrohalogeniert werden.
Ultrahigh growth rate of epitaxial silicon by chemical vapor deposition at low temperature with neopentasilane (2008)

A precursor, neopentasilane, is used to produce high-quality silicon epitaxy by chemical vapor deposition under 700°C with very high growth rates. Low background dopant concentration and excellent crystal quality were determined from secondary-ion-mass spectroscopy and cross sectional transmission electron microscopy. Growth rates as high as 130nm∕min at 600°C have been achieved. Growth rates in nitrogen and hydrogen ambients are about equal for neopentasilane, unlike those for growth with low-order silanes. A concerted reaction, where an open site is generated at the same time the adatom is adsorbed, is proposed as a possible mechanism for both the high growth rate with neopentasilane as well as the similar rate with hydrogen and nitrogen carriers.
I Know What You Type: Leaking User Privacy via Novel Frequency-Based Side-Channel Attacks (2018)

Smartphone sensors have been applied to record the movement of users for healthy use. However, the motion sensor readings recorded by malicious applications can be utilized as a side-channel to leak user privacy by keystroke inference. Most existing approaches use time-domain statistical characteristics for keystroke inference. Their systems are poor to show the subtle changes in short time period, since the time- domain statistical features can only reflect the characteristics in a long-time interval. In this paper, we propose a novel framework to perform keystroke inference on smartphones. This framework introduces an improved MFCC algorithm to extract frequency- domain features for more comprehensive use of raw data. Since the frequency-domain energy distribution of motion signals is concentrated, and the specificity of signals is strong, MFCC can improve the inference accuracies under complex scenarios. Based on this framework, we present a prototype called FreqKey, which is an inference system to leak user privacy such as PINs and passwords. FreqKey collects motion sensor readings during keystroke events and constructs classification models with machine learning algorithms. Experimental results show that FreqKey improves the performance in a variety of complex scenarios. Especially, even in web platform whose sampling rate is lower than 80Hz, FreqKey can achieve relatively high accuracy of 74.6%. To mitigate the frequency-based side-channel attack and protect user privacy, we propose a defense solution which contains sensor- activity monitoring, malicious program identification and interference signal injection.
Bendamustine HCl (TREANDATM) Treatment Results in High Rates of Objective Response in Patients with Rituximab-Refractory and Alkylator-Refractory Indolent B-Cell Non-Hodgkin’s Lymphoma (NHL): Results from a Phase II Multicenter Single-Agent Study (SDX-105-01). (2005)

Abstract Background: Bendamustine HCl (TreandaTM) is a multifunctional, alkylating agent with novel mechanisms of action. Unlike other commonly used chemotherapeutic agents, bendamustine in vitro induces durable cell damage resulting in rapid cell death in apoptosis-resistant cancer cell lines through the apoptosis independent pathway of mitotic catastrophe. European studies have reported single-agent activity in patients with relapsed/refractory NHL, chronic lymphocytic leukemia, multiple myeloma, and breast cancer. Aim: This study evaluated the efficacy and toxicity of bendamustine in patients with NHL who have relapsed or are refractory to previous chemotherapy regimens. Patients refractory to Rituximab had disease progression within 6 months of treatment. Methods: This Phase II multicenter trial enrolled patients with relapsed indolent or transformed rituximab-refractory B-cell NHL from 17 sites in the US and Canada. Indolent histologic phenotype was seen in 84% of patients, while 16% had transformed disease. Median age of patients was 63 years (range: 38–84) and 88% had Stage III/IV disease. Patients received bendamustine 120 mg/m2 IV over 30–60 minutes, days 1 and 2, every 21 days for up to 6 cycles. Response was measured using the International Working Group criteria. Results: The intent-to-treat (ITT) population consisted of 75 heavily pretreated patients with a median of 2 prior chemotherapies. The overall objective response rate (ORR) in the ITT population was 74%; 25% had a complete response, 49% had a partial response, 12% had stable disease, and 14% had disease progression. Of 15 patients who were refractory to prior alkylator treatment (patients who progressed after at least one prior alkylator-containing therapy), 10 (67%) experienced an objective response to bendamustine. The median duration of response was 6.6 months for all patients, 9.3 months for indolent patients, and 2.4 months for transformed patients. The most frequent nonhematologic adverse events were nausea (63%), fatigue (39%), vomiting (38%), fever (25%), and diarrhea (22%). Most of these events were grade 1 or 2; alopecia and hemorrhagic cystitis were not observed. Grade 3 or 4 reversible hematologic toxicities seen included neutropenia (47%), thrombocytopenia (24%), and anemia (11%). Conclusions: Single-agent bendamustine produced durable objective responses with acceptable toxicity, despite unfavorable prognostic features, in heavily pretreated rituximab-refractory indolent and transformed NHL patients. Durable response has been seen in alkylator-resistant patients. A Phase III trial with bendamustine as a single agent in patients with rituximab-refractory indolent NHL is ongoing.
Supplementary Table S1 from Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML (2023)

&lt;p&gt;Raw data associated with drug screen performed in Figure 1A.&lt;/p&gt;
ZCD-UWB system using enhanced ZCD codes (2004)

We propose a ZCD-UWB using zero correlation duration (ZCD) code for direct sequence-ultra wideband (DS-UWB). Then, we introduce a class of new ternary ZCD spreading codes with aperiodic and periodic ZCD property for ZCD-UWB and CDMA applications. After constructing a mathematical model for ZCD-UWD wireless communication system, we present theoretical bit error rate (BER) performance of the system. By using computer simulation, we verify the proposed system having high system capacity and superior performance to the Walsh code-based DS-UWB systems in multipath and in multiple access environments. Finally, we show that the proposed system can remove the interference signal perfectly without employing complicated hardware such as multiuser detection (MUD) or other interference cancellation techniques.
The cooperativity of nitric oxide hemoglobin ligand exchange in single crystals as studied by EPR (1984)

Single crystals of human oxyhemoglobin are exposed to aqueous solutions of nitric oxide at pH 6.7 and 6 °C. The EPR spectrum of crystals at 85–100 K selected after various times of exposure to NO are recorded. The intensities of the alpha and beta subunits are determined from the c axis spectrum of the crystal. With NO in stoichiometric excess, crystals sampled early (3–200 min) display the EPR of molecules with NO bound to an average of two alpha and one beta subunit. The NO diffuses into the crystals with a diffusion rate constant of 1.5×10−9 cm2 s−1.The NO binds to the last beta subunit at a rate of 5.1×10−6 s−1.
Einzelsubstanzbibliotheken organischer Materialien: von der kombinatorischen Synthese konjugierter Oligomere zu Struktur-Eigenschafts-Beziehungen (2001)

256 Oligomere umfasst die Quaterthiophenbibliothek, deren Elemente 1 mit einer Kombination aus Parallel- und „Mix-and-split“-Synthese erhalten wurden. Die mit einem neu entwickelten automatisierten Screening-Verfahren zur Aufnahme von Cyclovoltammogrammen erhaltenen Daten erlaubten die Aufstellung von Struktur-Eigenschafts-Beziehungen, die für ein künftiges Design derartiger π-konjugierter Oligomere relevant sind. Hintergrundinformationen zu diesem Beitrag sind im WWW unter http://www.angewandte.de zu finden oder können beim Autor angefordert werden. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Overall and Progression-Free Survival in Metastatic Melanoma: Analysis of a Single-Institution Database (2006)

In this retrospective review of patients treated at a single institution, those treated with multiagent chemotherapy but not with single-agent DTIC appeared to have had a survival benefit.
Repigmentation by Outer-Root-Sheath-Derived Melanocytes: Proof of Concept in Vitiligo and Leucoderma (2009)

Applying ORS-derived melanocytes is a promising technology to improve autologous melanocyte transplantation.