gebhart/patrepeval huggingface dataset:
Turbine Shroud Heat Transfer and Cooling With Blade Rotation: Part I — Forward, Backward and Lateral Injection (2017)

This is the first in a two-part series of an experimental film cooling study on a gas turbine shroud with a blade rotation speed of 1200 RPM. In this part of the study, the effect of forward, backward and lateral injection on the shroud heat transfer and cooling behavior is investigated. The shroud with a staggered hole arrangement and a hole pitch to diameter ratio of 4.0, consists of holes angled at 45° to the surface. Four hole configurations using inline and lateral coolant injection methods are utilized in this study. The first configuration consists of streamwise and forward facing holes inclined at 45 degrees to the surface (ϕ = 0°). The second configuration consists of backward facing holes also inclined at 45 degrees to the surface (ϕ = 180°). The third and fourth configurations consist of lateral injection with a surface angle of 45 degrees in the direction of blade rotation (ϕ = 90°) and opposite the direction of blade rotation (ϕ = 270°), respectively. The heat transfer coefficient is reported for the no-coolant case and measurements of the heat transfer coefficient and film cooling effectiveness are reported for each configuration at nominal blowing ratios of 0.5, 1.0, 1.5 and 2.0 using liquid crystal thermography. The results show that in-line injection performs better than lateral injection at low blowing ratios and the reverse is true at higher blowing ratios. Backward injection does show higher laterally averaged effectiveness with increased spreading in the vicinity of the coolant holes than forward injection. With a compact coolant hole arrangement, this results in higher area averaged effectiveness for backward injection than forward injection. With increased lateral spreading of the coolant in the hole region, lateral injection results in higher peak effectiveness values than inline injection. Nevertheless, lateral injection does not have the axial penetration of inline injection and as such leaves regions of the shroud downstream of the coolant holes vulnerable.
Genetically Encoded Indicators of Cellular Calcium Dynamics Based on Troponin C and Green Fluorescent Protein (2004)

Genetic calcium probes offer tremendous potential in the fields of neuroscience, cell biology, and pharmaceutical screening. Previously, ratiometric and non-ratiometric indicators of cellular calcium dynamics have been described that consist of mutants of the green fluorescent protein (GFP) as fluorophores and calmodulin as calcium-binding moiety in several configurations. However, these calmodulin-based types of probes have a series of deficiencies, such as reduced dynamic ranges, when expressed within transgenic organisms and lack of calcium sensitivity in certain targetings. We developed novel types of calcium probes based on troponin C variants from skeletal and cardiac muscle. These indicators have ratio changes up to 140%, K(d)s ranging from 470 nm to 29 microm, and improved subcellular targeting properties. We targeted the indicators to the plasma membrane of HEK293 cells and primary hippocampal neurons. Upon long lasting depolarization, submembrane calcium levels in hippocampal neurons were found to be in equilibrium with bulk cytosolic calcium levels, suggesting no standing gradient persists from the membrane toward the cytosol. We expect that such novel indicators using specialized calcium sensing proteins will be minimally interacting with the cellular biochemical machinery.
Tin-Free Synthesis of a Ternary Random Copolymer for BHJ Solar Cells: Direct (Hetero)arylation versus Stille Polymerization (2015)

In a recent report (Eur. J. Org. Chem. 2014, 30, 6583) we emphasized the importance of addressing research efforts in OPV-active materials toward synthetic processes scalable up to industrial production. In this context, palladium-catalyzed direct (hetero)arylation polymerization (DHAP) can be a suitable approach to reduce the number of reaction steps and to avoid the use of toxic reagents in the synthesis of donor polymers. Random donor–acceptor copolymers have been shown to be promising materials for bulk heterojunction (BHJ) solar cells with high efficiencies and increased thermal stability. We report here the synthesis by DHAP of a ternary double-acceptor/donor random copolymer including benzo[c][1,2,5]thiadiazole and benzo[d][1,2,3]triazole as the accepting units and benzo[1,2-b;4,5-b′]dithiophene as the donor moiety. The results are discussed in comparison with the synthesis of the same polymer via the Stille polymerization. The coupling products formed in the early stage of the polycondensation have been isolated and characterized by NMR spectroscopy to gain insight into the regiochemistry of DHAP. The polymers synthesized have been tested in BHJ solar cells with PC71BM as the electron acceptor material. Power conversion efficiencies (up to 2.8%) are comparable or lower (depending on the processing conditions) than those of the same polymer synthesized via the Stille coupling reaction; however, the DHAP protocol is more convenient in terms of synthetic complexity.
Optical Network Resource Management Supporting Physical Layer Reconfiguration (2019)

To cope with the capacity increase and diversification of information services, enhancing efficiency, flexibility, and agility in optical transport networks is becoming increasingly important. Quick reconfiguration of the optical physical layer, such as changing optical node architectures or optical physical network topologies, provides additional adaptability to requirement or environment changes. This paper proposes a new topology description scheme to support optical physical layer resource management at the granularity of optical functionality blocks in a machine-processible manner. The proposed scheme specifies intra-node structures as well as inter-node fiber connections (links). Furthermore, different switching functionalities of individual optical components are specified in a common format using integer linear programming (ILP) formulas. The ILP formulas are described in a machine-readable GNU MathProg modeling language so as to be directly introduced to the path computation mechanisms. Based on the proposed topology description scheme, a path computation engine named PathFinder is prototyped and demonstrated for optical networks consisting of various optical components with different switching functionalities. The computational feasibility of PathFinder is evaluated through numerical experiments in terms of elapsed time for path computation and the proposed scheme is successful while retaining reasonable time ranges. Operating topology and node architecture changes based on the proposed scheme are also successfully demonstrated over a multi-granular hierarchical optical network testbed with real hardware.
Firestorms (1985)

Quantitative criteria are sought for onset of firestorms, severe stationary (non-propagating) holocausts arising via merger of fires from multiple simultaneous ignitions in a heavily fuel-laden urban environment. Within an hour, surface-level radial inflow from all directions sustains a large-diameter convective column that eventually reaches altitude of about 10 km (e.g., Hamburg, Dresden, Hiroshima). As the firestorm achieves peak intensity (a couple of hours after the ignitions), inflow speeds are inferred to attain 25–50 m/s; typically 12 km2 are reduced to ashes, before winds relax to ambient levels in six-to-nine hours. Here the firestorm is interpreted to be a mesocyclone (rotating severe local storm). Even with exceedingly large heat release sustained over a concentrated area, in the presence of a very nearly autoconvectively unstable atmospheric stratification, onset of vigorous swirling on the scale of 2 hrs requires more than concentration of circulation associated with the rotation of the earth; rather, a preexisting, if weak, circulation appears necessary for firestorm cyclogenesis.
Repair-Mediated Duplication by Capture of Proximal Chromosomal DNA Has Shaped Vertebrate Genome Evolution (2009)

DNA double-strand breaks (DSBs) are a common form of cellular damage that can lead to cell death if not repaired promptly. Experimental systems have shown that DSB repair in eukaryotic cells is often imperfect and may result in the insertion of extra chromosomal DNA or the duplication of existing DNA at the breakpoint. These events are thought to be a source of genomic instability and human diseases, but it is unclear whether they have contributed significantly to genome evolution. Here we developed an innovative computational pipeline that takes advantage of the repetitive structure of genomes to detect repair-mediated duplication events (RDs) that occurred in the germline and created insertions of at least 50 bp of genomic DNA. Using this pipeline we identified over 1,000 probable RDs in the human genome. Of these, 824 were intra-chromosomal, closely linked duplications of up to 619 bp bearing the hallmarks of the synthesis-dependent strand-annealing repair pathway. This mechanism has duplicated hundreds of sequences predicted to be functional in the human genome, including exons, UTRs, intron splice sites and transcription factor binding sites. Dating of the duplication events using comparative genomics and experimental validation revealed that the mechanism has operated continuously but with decreasing intensity throughout primate evolution. The mechanism has produced species-specific duplications in all primate species surveyed and is contributing to genomic variation among humans. Finally, we show that RDs have also occurred, albeit at a lower frequency, in non-primate mammals and other vertebrates, indicating that this mechanism has been an important force shaping vertebrate genome evolution.
Design of robust fault isolation observers for linear systems with bounded uncertain parameters (2015)

Summary In this article, a design procedure for robust fault isolation observers for linear systems is proposed. It allows to detect and isolate faults by means of a single, specifically parametrized observer, yielding a small implementation effort compared with standard bank‐of‐observers approaches. A design based on parametric eigenstructure assignment for nominal system dynamics is presented. The main contribution is to show how the remaining degrees of freedom can be utilized to optimize robustness of the fault isolation observer with respect to uncertain system parameters. Therein, the uncertainties are assumed to belong to a polyhedral domain. The application of the design to two examples verifies the results for systems defined by nominal dynamics and known bounds on the uncertain parameters. Copyright © 2015 John Wiley &amp; Sons, Ltd.
Three-dimensional MR Cholangiopancreatography in a Breath Hold with Sparsity-based Reconstruction of Highly Undersampled Data (2016)

Purpose To develop a three-dimensional breath-hold (BH) magnetic resonance (MR) cholangiopancreatographic protocol with sampling perfection with application-optimized contrast using different flip-angle evolutions (SPACE) acquisition and sparsity-based iterative reconstruction (SPARSE) of prospectively sampled 5% k-space data and to compare the results with conventional respiratory-triggered (RT) acquisition. Materials and Methods This HIPAA-compliant prospective study was institutional review board approved. Twenty-nine patients underwent conventional RT SPACE and BH-accelerated SPACE acquisition with 5% k-space sampling at 3 T. Spatial resolution and other parameters were matched when possible. BH SPACE images were reconstructed by enforcing joint multicoil sparsity in the wavelet domain (SPARSE-SPACE). Two board-certified radiologists independently evaluated BH SPARSE-SPACE and RT SPACE images for image quality parameters in the pancreatic duct and common bile duct by using a five-point scale. The Wilcoxon signed-rank test was used to compare BH SPARSE-SPACE and RT SPACE images. Results Acquisition time for BH SPARSE-SPACE was 20 seconds, which was significantly (P < .001) shorter than that for RT SPACE (mean ± standard deviation, 338.8 sec ± 69.1). Overall image quality scores were higher for BH SPARSE-SPACE than for RT SPACE images for both readers for the proximal, middle, and distal pancreatic duct, but the difference was not statistically significant (P > .05). For reader 1, distal common bile duct scores were significantly higher with BH SPARSE-SPACE acquisition (P = .036). More patients had acceptable or better overall image quality (scores ≥ 3) with BH SPARSE-SPACE than with RT SPACE acquisition, respectively, for the proximal (23 of 29 [79%] vs 22 of 29 [76%]), middle (22 of 29 [76%] vs 18 of 29 [62%]), and distal (20 of 29 [69%] vs 13 of 29 [45%]) pancreatic duct and the proximal (25 of 28 [89%] vs 22 of 28 [79%]) and distal (25 of 28 [89%] vs 24 of 28 [86%]) common bile duct. Conclusion BH SPARSE-SPACE showed similar or superior image quality for the pancreatic and common duct compared with that of RT SPACE despite 17-fold shorter acquisition time. (©) RSNA, 2016.
The role of platelets in the pathophysiology of asthma (2007)

The incidence of asthma is on the increase worldwide, yet the pathogenesis of this disease is still not fully understood. Many recent drug trials have had disappointing results, thus fuelling the need for more research to be undertaken in this area. Substantial evidence suggests an important role for platelets in various inflammatory diseases, including atherosclerosis, rheumatoid arthritis, eczema, allergic rhinitis and asthma. In asthma, platelets have been found to actively participate in most of its main features, including bronchial hyperresponsiveness, bronchoconstriction, airway inflammation and airway remodelling. It has recently become clear that platelet-release products, as well as the expression of adhesion molecules on the platelet surface and the ability to undergo chemotaxis, are all involved in these processes. This review focuses on both experimental and clinical studies available to date that have investigated the role of platelets in the pathophysiology of asthma. Taken together, the evidence points toward platelets being an attractive new target in the area of asthma research; a target with much-needed novel therapeutic potential.
Extracellular matrix proteins of human epidermal keratinocytes and feeder 3T3 cells. (1982)

Cultures of human epidermal keratinocytes obtained from adult epidermis were initiated using irradiated BALB/3T3 cells as feeder layers. At different stages of confluence of the epidermal islands, feeder cells were removed and the extracellular matrix proteins of both pure component cells and cocultures were analyzed biochemically and by immunochemical methods and compared to those of skin fibroblasts of the same donors. The keratinocytes synthesized and secreted fibronectin and small amounts of laminin and type IV collagen. In addition, a nondisulfide-linked collagenous polypeptide (Mr = 120,000) was synthesized by the keratinocytes and was confined to the cell layers. Collagenous polypeptides with Mr = 120,000 were also synthesized by organ cultures of epidermal tissue and were detected in its acid or detergent extracts but again no secretion to culture medium was found. The Mr = 120,000 collagen had biochemical and immunological properties distinct from those of types I-V collagens. In immunofluorescence of keratinocyte cultures, fibronectin staining was prominent in the lining marginal cells of the expanding periphery of the epidermal cell islands but was not detected in the terminally differentiating cells in the upper layers of stratified colonies. Very little type IV collagen was found deposited in pericellular matrix form by the keratinocytes. In contrast, the mouse 3T3 feeder cells were found to produce both type IV collagen and laminin in addition to the previously identified connective tissue glycoproteins of fibroblasts, interstitial procollagens, and fibronectin. Basement membrane collagen of the 3T3 cells was found deposited as apparently unprocessed procollagen alpha 1(IV) and alpha 2(IV) chains. The production in culture conditions of basal lamina glycoproteins by the fibroblastic feeder cells may promote the attachment and growth of the cocultured keratinocytes.
High-fidelity Rydberg-blockade entangling gate using shaped, analytic pulses (2016)

We show that the use of shaped pulses improves the fidelity of a Rydberg-blockade two-qubit entangling gate by several orders of magnitude compared to previous protocols based on square pulses or optimal control pulses. Using analytical derivative removal by adiabatic gate (DRAG) pulses that reduce excitation of primary leakage states and an analytical method of finding the optimal Rydberg blockade, we generate Bell states with a fidelity of $F&gt;0.9999$ in a 300 K environment for a gate time of only $50\phantom{\rule{0.28em}{0ex}}\mathrm{ns}$, which is an order of magnitude faster than previous protocols. These results establish the potential of neutral atom qubits with Rydberg-blockade gates for scalable quantum computation.
Do’s and Don’ts of writing a good paper (2020)

Abstract -Congratulations! Your chip finally works and now you want to write a paper about it. Now you wonder: “Where to start? What will be my title? Shall I put a lot of measured numbers in the title, or make it fancy marketing style? What should the introduction be about? What should I present as measurements? Which numbers are important to show? How to compare to state of art?” These are questions that arise when writing your paper. And when finally done, it comes back with a lot of reviewer’s comments. Some are mild while some may trash your hard work below ground level. How to deal with that? How can you smoothly bend the critics to something positive in your paper? And if the reviewer did not understand what you actually meant to say, what can you do to fix this? How to understand the viewpoints of the reviewers? This lecture is about the Do’s and Don’ts of writing a paper with focus on the IEEE Solid-State Circuits Society’s publications. Also, there will be room for questions &amp; discussions. Speaker Bio - Professor Bram Nauta leads the IC Design group at the university of Twente, Enschede, The Netherlands. Has been the editor in chief of IEEE Journal of solid-state circuits (2007-2010). Moreover, he was active in the technical program committees of various SSCS conferences like ESSCIRC, VLSI Symposium on Circuits, ESSCIRC and ISSCC. For the latter conference he served as technical program committee chair in 2013. Bram also served as the president of the IEEE Solid-State Circuits Society (2018-2019). In his various roles he has experienced most sides of the publication process.
ChemInform Abstract: Synthesis and Anti‐HIV‐1 Activity of Novel 2,3‐Dihydro‐7H‐thiazolo[3,2‐a]pyrimidin‐7‐ones. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Computerized microreactor and video microscopy system for coal pyrolysis studies (1988)

The development of a captive sample microreactor, its integration into a video microscopy system, and its use for studies on coal pyrolysis are presented. The reactor can operate as a high-temperature microscope hot stage allowing for direct viewing of the pyrolysis process under an optical microscope equipped with a video camera. By using a microcomputer and specialized video equipment, process information such as elapsed time and reactor temperature are superimposed in alphanumeric form on the video signal. Complete histories of fast experiments can thus be stored on videotape for postprocessing and analysis of transient phenomena. The reactor is controlled via a microcomputer with custom-built analog interfaces. A digital algorithm combining internal model control and feedback control is implemented for accurate programming of the reactor temperature. Heating rates as high as 1000 °C/s can be achieved with good reproducibility. Some experimental results are presented to outline the capabilities of the apparatus and to suggest other potential applications.
Outcome Comparison of Workers' Compensation and Noncompensation Low Back Pain in a Highly Structured Functional Restoration Program (1995)

Low back pain is both common and costly. A paucity of information exists within the literature comparing workers' compensation and noncompensation back-injured individuals. The intent of this study was to examine differences between the two groups--individuals injured and seeking compensation, and injured individuals not pursuing a compensation claim. Sixty subjects referred to a functional restoration facility were identified and evaluated, and their progress was tracked. Demographic and return-to-employment data were collected. Of the 35 workers' compensation subjects, 23 (65.71%) were not working during therapy, while only one of 25 noncompensation individuals was not working throughout treatment. Thirty-two compensation individuals (91%) and all of the noncompensation group members made successful returns to employment (p < or = .05). The authors conclude that while some differences existed between the two groups, a high return-to-work frequency was achieved (91%) (p < or = .05). Results indicate high success outcomes as measured by return-to-work, increased function, and reduced pain. These outcomes were obtained through highly structured, medically supervised functional restoration programs.
Abstract IA04: Stromal regulation of pancreatic cancer epigenome and metabolome (2016)

Abstract A hallmark of pancreatic ductal adenocarcinoma (PDAC) is the dramatic accumulation of stromal components implicated in tumor growth, metastasis, and resistance to therapy. This creates a living chimera in which stroma-derived growth factors, matrix proteins and inflammatory cytokines are thought to nurture the nascent tumor. This study reveals that the stromal secretome exerts rapid epigenomic changes in the cancer cells that effectively marshals up metabolic and genomic networks needed to power cell growth. To tackle the complexity of the tumor microenvironment (TME), we devised a three-dimensional culture system to dissect the adaptive impact of the stromal secretome on the cancer cell. This integrative approach identified the rapid mobilization of more than a dozen gene networks (cell cycle, steroid biosynthesis, metabolic pathways, DNA replication, etc.), as well as a commensurate adaptive metabolome. A major unanswered question relates to the sequence of events that result in the formation and ultimate function of these networks, in part generated by rapid changes in acetylation of histone H3 at lysines 9 and 27 (H3K9ac and H3K27ac). Our work suggests the existence of a molecular and-gate such that tumor activation is the consequence of mutant Ras and the tumor micro-environment. To mediate this molecular hand-shake, we find that BRD2 acts in the epithelial compartment to transduce stromal cues at the genomic level. Based on the above, and consistent with recent Mazur PK et al Nat Med (2015), we show the BET bromodomain inhibitor JQ1 targets a key synergy point and reduces pancreatic tumor growth in vivo. Collectively, this work describes a novel connection between the stromal response and a driver oncogene and may offer new insights into the role of the TME in the treatment of ras-driven tumor. Citation Format: Mara H. Sherman, Ronald Evans. Stromal regulation of pancreatic cancer epigenome and metabolome. [abstract]. In: Proceedings of the AACR Special Conference: Function of Tumor Microenvironment in Cancer Progression; 2016 Jan 7–10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2016;76(15 Suppl):Abstract nr IA04.
Network File System (NFS) Version 4 Minor Version 2 Protocol (2016)

4 minor version 1. Major extensions introduced in NFS version 4 minor version 2 include the following: Server-Side Copy, Application Input/Output (I/O) Advise, Space Reservations, Sparse Files, Application Data Blocks, and Labeled NFS.