gebhart/patrepeval huggingface dataset:
Isolation and characterization of polyfucosylated lactosaminoglycan from human granulocytes. (1984)

Lactosaminoglycan was isolated from human granulocytes and the structure of neutral lactosaminoglycan was elucidated. The lactosaminoglycan glycopeptides and lactosaminoglycan saccharides obtained by hydrazinolysis were analyzed by permethylation. In addition, the lactosaminoglycan was digested by endo-beta-galactosidase and the "core" portion and released oligosaccharides were analyzed by specific glycosidases, permethylation, and fast atom bombardment mass spectrometry. The structure of the major component in the neutral lactosaminoglycan was found to be: sequence in text where m + n + o + p greater than 6, and the mean value of fucose content = 4.5. This structure is unique in that 1) four linear polylactosaminyl chains are attached to the core portions, 2) N-acetylglucosamine residues in the polylactosaminyl side chains are substituted with fucose through an alpha 1----3 linkage and at least 1 mol of Gal beta 1----4(Fuc alpha 1----3)GlcNAc terminal structure is present, and 3) the tetraantennary core is a major component. Since this polyfucosylated lactosaminoglycan is abundantly present in human granulocytes, we propose that this lactosaminoglycan is a major carrier for the granulocyte-specific antigen, Gal beta 1----4(Fuc alpha 1----3)GlcNAc, which is recognized by the My-1 monoclonal antibody (Huang, L. C., Civin, C. I., Magnani, J. L., Shaper, J. H., and Ginsburg, V. (1983) Blood 61, 1020-1023).
Validation and clinicopathologic associations of a urine-based bladder cancer biomarker signature (2014)

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_200.
The Greenblatt chess program (1967)

Since mid-November 1966 a chess program has been under development at the Artificial Intelligence Laboratory of Project MAC at M.I.T. This paper describes the state of the program as of August 1967 and gives some of the details of the heuristics and algorithms employed.
Serum Sialyltransferase and 5′-Nucleotidase as Reliable Biomarkers in Women With Breast Cancer<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref> (1980)

Sialyltransferase and 5'-nucleotidase were measured in the sera of 135 women with breast cancer: 53 undergoing mastectomy for primary cancer and 83 receiving different modalities of palliative therapy for metastatic disease. The objective of this study was to determine whether these enzyme levels were associated with the extent of the disease and whether changes in these enzyme levels could be correlated with success or failure of treatment. Mastectomy caused a rapid fall of elevated enzyme levels to within the normal range in all patients with stage I breast cancer but not in those with stage II or III disease. In women with metastatic disease, elevated enzyme levels fell only in patients responding to treatment. Thus serum sialyltransferase and 5'-nucleotidase activities are reliable biomarkers of breast cancer activity, and serial measurement of these enzyme activities provides a useful tool for the monitoring of disease activity and success or failure of the treatment.
Prior hydration of Brassica tournefortii seeds reduces the stimulatory effect of karrikinolide on germination and increases seed sensitivity to abscisic acid (2010)

Seed water content and history of imbibition were found to significantly influence whether seeds germinate in response to KAR(1). To optimize the germination response of seeds, KAR(1) should be applied to dry seeds, when sensitivity to ABA is minimized.
Structural Characterization of Graphene Grown by Thermal Decomposition of Off-Axis 4H-SiC (0001) (2012)

We present a nanoscale morphological and structural characterization of few layers of graphene grown by thermal decomposition of off-axis 4H-SiC (0001). A comparison between transmission electron microscopy (TEM) in cross-section and in plan view allows to fully exploit the potentialities of TEM. Such a comparison was used to get information on the number of graphene layers as well as on the rotational order between the layers and with respect to the substrate. Some peculiar structures observed by TEM (wrinkles) could only be systematically measured by atomic force microscopy (AFM). In particular, the density and the height of the wrinkles in the few layers of graphene was investigated.
Test for temporal or spatial restrictions in gene product function during the cell division cycle. (1983)

The ability of a functional gene to complement a nonfunctional gene may depend upon the intracellular relationship of the two genes. If so, the function of the gene product in question must be limited in time or in space. CDC (cell division cycle) gene products of Saccharomyces cerevisiae control discrete steps in cell division; therefore, they constitute reasonable candidates for genes that function with temporal or spatial restrictions. In an attempt to reveal such restrictions, we compared the ability of a CDC gene to complement a temperature-sensitive cdc gene in diploids where the genes are located within the same nucleus to complementation in heterokaryons where the genes are located in different nuclei. In CDC X cdc matings, complementation was monitored in rare heterokaryons by assaying the production of cdc haploid progeny (cytoductants) at the restrictive temperature. The production of cdc cytoductants indicates that the cdc nucleus was able to complete cell division at the restrictive temperature and implies that the CDC gene product was provided by the other nucleus or by cytoplasm in the heterokaryon. Cytoductants from cdc28 or cdc37 crosses were not efficiently produced, suggesting that these two genes are restricted spatially or temporally in their function. We found that of the cdc mutants tested 33 were complemented; cdc cytoductants were recovered at least as frequently as CDC cytoductants. A particularly interesting example was provided by the CDC4 gene. Mutations in CDC4 were found previously to produce a defect in both cell division and karyogamy. Surprisingly, the cell division defect of cdc4 nuclei is complemented by CDC4 nuclei in a heterokaryon, whereas the karyogamy defect is not.
Measured Thermal and Fast Neutron Fluence Rates ATR Cycles 167A (2020)

This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for ATR Cycle 167A which were measured by the Radiation Measurements Laboratory (RML) as requested by the Power Reactor Programs (ATR Experiments) Radiation Measurements Work Order. The report contains fluence rate values corresponding to the particular elevations (relative to the 80-ft. core elevation) where the measurements were taken. The data in this report consists of (1) a table of the ATR power history and distribution, (2) a hard copy listing of all thermal and fast neutron fluence rates, (3) plots of both the thermal and fast neutron fluence rates.
Molecular remission in chronic myeloid leukemia patients with sustained complete cytogenetic remission after imatinib mesylate treatment. (2006)

Molecular remission after imatinib treatment, i.e. BCR-ABL/ABL< 10-5 in peripheral blood, is not a rare event, particularly in patients achieving CCR at 6 months.
Altered glycosylation of exported proteins, including surface immune receptors, compromises calcium and downstream signaling responses to microbe-associated molecular patterns in Arabidopsis thaliana (2016)

Proper glycosylation of MAMP receptors (or other exported proteins) is required for optimal responses to MAMPs and is important for immune signaling of host plants.
Triosephosphate isomerase deficiency: a neurodegenerative misfolding disease (2002)

A number of neurodegenerative diseases are mediated by mutation-induced protein misfolding. The resulting genetic defects, however, are expressed in varying phenotypes. Of the several well-established glycolytic enzyme deficiencies, triosephosphate isomerase (TPI) deficiency is the only one in which haemolytic anaemia is coupled with progressive, severe neurological disorder. In a Hungarian family with severe decrease in TPI activity, two germ line-identical but phenotypically differing compound heterozygote brothers inherited two independent (Phe(240)-->Leu and Glu(145)-->stop codon) mutations. We have demonstrated recently [Orosz, Oláh, Alvarez, Keserü, Szabó, Wágner, Kovári, Horányi, Baróti, Martial, Hollán and Ovádi (2001) Blood 98, 3106-3112] that the mutations of TPI explain in themselves neither the severe decrease in the enzyme activity characteristic of TPI deficiency nor the enhanced ability of the mutant enzyme from haemolysate of the propositus to associate with subcellular particles. Here we present kinetic (flux analysis), thermodynamic (microcalorimetry and fluores cence spectroscopy), structural (in silico) and ultrastructural (immunoelectron microscopy) data for characterization of mutant isomerase structures and for the TPI-related metabolic processes in normal and deficient cells. The relationships between mutation-induced TPI misfolding and formation of aberrant protein aggregates are discussed.
Asymmetric directional coupler type contra-directional polarization rotator Bragg grating: design (2019)

We report contra-directional coupler type polarization rotation Bragg gratings using silicon waveguides. Waveguides incorporating a Bragg grating for polarization rotation and having different widths are placed near to each other. A single grating can separate the backward diffraction light. The structure is optimized considering the field strength ratio between waveguides. A distinct polarization rotation wavelength peak is obtained by 3D-FDTD simulation.
Abstract SY11-03: Circulating tumor DNA as a non-invasive diagnostic and research tool. (2013)

Abstract In patients with solid malignancies, cell-free DNA carrying tumor-specific sequences can be found in body fluids such as blood plasma. This circulating tumor DNA (ctDNA) contains representation of the entire cancer genome, broken down into short mutation-carrying fragments, whose relative levels vary in response to treatment and progression. Different approaches to the study of ctDNA can work together to provide a window for noninvasive analysis of the cancer genome and its dynamics. Quantification of ctDNA levels may be useful as a prognostic biomarker and to assess response to treatment. When cancer overcomes treatment and progresses, the fraction of mutant alleles in plasma DNA can reach levels of 10%~20% or more, which makes it possible to study cancer evolution noninvasively by whole-genome or exome analysis of plasma DNA. Sensitivity and resistance to targeted therapies are often associated with known mutations in hotspot loci or genes. In advanced cancer patients, the status of pre-defined mutations can be analyzed noninvasively using circulating plasma DNA as a liquid biopsy. Targeted sequencing of limited regions in circulating DNA can allow identification of de novo mutations, even when these are present as rare fragments. This also facilitates parallel quantification of multiple mutations in plasma, which can indicate the relative systemic burden of different mutations or clones. Routine monitoring for sensitizing and resistance-conferring mutations may provide a framework for rational adaptive cancer therapy, providing real-time information on mutation levels to guide treatment against the most aggressive or treatable clones. Citation Format: Nitzan Rosenfeld. Circulating tumor DNA as a non-invasive diagnostic and research tool. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr SY11-03. doi:10.1158/1538-7445.AM2013-SY11-03
Efficient Analog Defect Simulation (2019)

Simulation of defects in industrial analog and mixed-signal (A/MS) circuits has long been regarded as impractical: how to simulate the tens of thousands of potential defects for each test and significant process corner of a PLL or SerDes, for example, when simulating each defect could require hours or days of simulation? Would the results for a subset be useful? This paper shows an efficient flow, consistent with the proposed IEEE P2427 Standard for Analog Defect Modeling and Coverage. The flow describes development of realistic models for hard/catastrophic and soft/parametric defects, introduces analog defect collapsing, discusses coverage results for an ITC'17 A/MS benchmark bandgap voltage reference plus LDO voltage regulator, and a programmable PLL, and shows why the results are applicable to large circuits. The results also show that some strategies are more useful than others.
Self-patterning nano-electrodes on ferroelectric thin films for gigabit memory applications (1998)

In the present work, we report self-assembling bismuth-containing nano-electroded cells of layered perovskite ferroelectric thin films that are about 200 nm in size, that is 50 times smaller than the smallest cell reported to date. Heteroepitaxial Bi-rich Bi4Ti3O12 films were grown by pulsed laser deposition (PLD) on top of epitaxial conductive La0.5Sr0.5CoO3 (LSCO) layers equally deposited by PLD. The epitaxial LSCO has been grown on top of an epitaxial CeO2 yttrium-stabilized zirconia (YSZ) stack, itself deposited by PLD on Si(100) substrates. As a consequence of the high substrate temperature during the epitaxial deposition of the Bi4Ti3O12 layer, the excess Bi segregates, migrates to the surface where it forms a self-organized array of epitaxial mesas which possess metallic-like electrical characteristics.
Chronische Durchfallerkrankungen - Differenzialdiagnostik für Hausarzt und Klinik (2008)

„Chronische Diarrhö“ ist eines der internistischen Krankheitsbilder mit den meisten Differenzialdiagnosen. Die zahlreichen zur Abklärung in Frage kommenden diagnostischen Prozeduren sind zum Teil aufwendig, invasiv oder teuer. Diese Übersicht soll helfen, anhand einer Basisdiagnostik zu entscheiden, ob und welche weiterführende Evaluation zum Auffinden einer behandlungsbedürftigen organischen Erkrankung notwendig ist.
Translational systems biology understanding the limits of animal models as predictors of human biology (2013)

Inferring how humans respond to external cues such as drugs, chemicals, viruses or hormones is an essential question in biomedicine. Very often, however, this question cannot be addressed due to the impossibility to perform experiments in humans. A reasonable alternative consists of generating responses in animal models and “translating” the results to humans. The limitations of such translation, however, are far from clear, and systematic assessments of its actual potential are badly needed. We have designed a series of challenges in the context of the ‘sbv IMPROVER’ project (Industrial Methodology for Process Verification in Research; http://sbvimprover.com/ ) to address the issue of translatability between humans and rodents. Our main aim is to understand the limits and opportunities of species to species translatability at different levels of biological organization: signalling, transcriptional, and release of secreted factors (such as cytokines, chemokines or growth factors) leveraging large scale omics datasets specially generated for this purpose. The sbv IMPROVER project are part of a collaborative project designed to enable scientists to learn about and contribute to the development of a new crowd sourcing method for verification of scientific data and results.
Learning dependencies between case frame slots (1996)

We address the problem of automatically acquiring case frame patterns (selectional patterns) from large corpus data. In particular, we l)ropose a method of learning dependencies between case frame slots. We view the problem of learning case frame patterns as that of learning a multi-dimensional discrete joint distribution, where random variables represent case slots. We then for-mMize the dependencies between case slots as the probabilislic dependencies between these random variables. Since the number of parameters in a multidimensional joint distribution is exponential in general, it is infeasible to accurately estimate them in practice. To overcome this difficulty, we settle with approximating the target joint distribution by the product of low order component distributions, based on corpus data. In particular we propose to employ an efficient learning algorithm based on the MDL principle to realize this task. Our experimental results indicate that for certain classes of verbs, the accuracy achieved in a disambiguation experiment is improved by using the acquired knowledge of dependencies.
Energy yield of all thin‐film perovskite/CIGS tandem solar modules (2018)

Abstract Perovskite/CuIn 1 − x Ga x Se 2 (CIGS) tandem photovoltaics (PV) promises high power conversion efficiencies in combination with the advantages of a light weight and an all thin‐film PV technology. However, the complexity of perovskite/CIGS tandem solar module architectures requires careful optimization of the layer stack under realistic solar irradiation conditions. Here, we provide a systematic numerical study on the energy yield (EY) of perovskite/CIGS tandem solar modules, optimizing the device architecture with regard to irradiance in various climate zones. In particular, variations of the spectral irradiation and the average photon energy are of decisive importance for the location‐specific optimization of the device architecture. Compared with the reference single‐junction CIGS thin‐film PV technology, we demonstrate a strong improvement in EY (&gt;30%) in perovskite/CIGS thin‐film PV for perovskites of a wide range of bandgaps (1.55 ‐ 2.0 eV), reaching up to 52% improvement in EY for the optimal bandgap (around 1.8 eV). Of the two most favored architectures, the two‐terminal and four‐terminal devices, perovskite/CIGS tandem solar modules with low bandgap (∼1.55 eV) perovskite absorbers in the four‐terminal architecture outperform those in the two‐terminal architecture in average by 3.5% relative. However, for wide perovskite bandgaps ranging from 1.75 eV to 1.85 eV, both architectures perform comparably. The improvements in EY for perovskite/CIGS tandem solar modules highlight the potential of this technology but also the vital need for light management in tandem photovoltaics.
A Practical Method for Epoxidation of Terminal Olefins with 30% Hydrogen Peroxide under Halide-Free Conditions (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTA Practical Method for Epoxidation of Terminal Olefins with 30% Hydrogen Peroxide under Halide-Free ConditionsKazuhiko Sato, Masao Aoki, Masami Ogawa, Tadashi Hashimoto, and Ryoji NoyoriView Author Information Department of Chemistry and Molecular Chirality Research Unit, Nagoya University, Chikusa, Nagoya 464-01, Japan Cite this: J. Org. Chem. 1996, 61, 23, 8310–8311Publication Date (Web):November 15, 1996Publication History Received9 July 1996Published online15 November 1996Published inissue 15 November 1996https://pubs.acs.org/doi/10.1021/jo961287ehttps://doi.org/10.1021/jo961287ebrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views3461Altmetric-Citations266LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anions,Aromatic compounds,Catalysts,Hydrocarbons,Organic reactions Get e-Alerts
A Method of LFSR Seed Generation for Scan-Based BIST Using Constrained ATPG (2013)

This paper proposes a method of LFSR seed generation for scan-based BIST of VLSI circuits. The proposed method targets static faults and utilizes a commercial ATPG tool. Experimental results show that the proposed method can improve fault coverage and reduce the number of seeds compared with the conventional seed generation.
Performance enhancement of an optical interconnect using short pulses from a modelocked diode laser (2003)

Summary form only given. We have demonstrated a short-pulse optical interconnect that uses a practical, high-repetition-rate modelocked source. BER measurements show that operation with short pulses improves system performance by providing a receiver sensitivity enhancement of 3.3 dB. The link has additional benefits related to timing issues and latency reduction.
Specific Heat near the Critical Concentration for the Dilute Simple-Cubic MagnetCopZn1−p(C5H5NO)6(ClO4)2 (1979)

The specific heat of the diluted simple-cubic antiferromagnetic system ${\mathrm{Co}}_{p}{\mathrm{Zn}}_{1\ensuremath{-}p}{({\mathrm{C}}_{5}{\mathrm{H}}_{5}\mathrm{NO})}_{6}{(\mathrm{Cl}{\mathrm{O}}_{4})}_{2}$ has been studied for $0.11&lt;~p&lt;~1$. It is shown that for $p={p}_{c}=0.31$ (the percolation threshold for the simple-cubic lattice) the specific-heat anomaly is excellently described by the prediction for a linear-chain antiferromagnet.
Correction: Synergistic Cooperation between Methamphetamine and HIV-1 gsp120 through the P13K/Akt Pathway Induces IL-6 but not IL-8 Expression in Astrocytes (2013)

HIV-1 envelope protein gp120 has been extensively studied for neurotoxic effects that have been attributed to the increased expression of various proinflammatory cytokines in the CNS. Recently we have shown that methamphetamine (MA) also increases expression of proinflammatory cytokines in astrocytes. However, combined effect of gp120 and MA is not known. The present study was undertaken to determine cumulative effect and the mechanism(s)/pathways involved in the functional interaction between gp120 and MA in SVGA astrocytes. Our results clearly suggest that gp120 and MA affect IL-6 but not IL-8 in a synergistic manner and this synergy was mediated by PI3K/Akt and NF-kB pathways. Inhibition of either of these pathways could abrogate the increased expression of IL-6 due to MA or gp120 alone, as well as the increased expression of IL-6 when the astrocytes were treated with both gp120 and MA. These results were confirmed by both, using chemical inhibitors/siRNA as well as western blotting. This study therefore provides novel information regarding the interaction between MA and gp120 in terms of the expression of IL-6 and the mechanisms underlying potential synergy between MA and gp120 in astrocytes.