gebhart/patrepeval huggingface dataset:
[Bronchial obstruction exacerbated during beta blocker therapy]. (1989)

The authors analyse data of 40 patients with chronic obstructive pulmonary disease, in whom the bronchial obstruction made such a severe progress during beta-blocker therapy necessary to admit them to the hospital. Most of them were middle-aged patients with chronic bronchitis, only 8 suffered from bronchial asthma. Because of cardial disorders, usually beta-blockers were given for several days (1/3-rd of the patients received Betaloc, a cardioselective drug), besides 2/3-rd of them received bronchodilator therapy, too. In spite of this, all patients needed hospitalize because of dyspnoea, obstruction, and hypoxaemia in 1/3-rd. Although deterioration of their condition has resulted, beta-blocker wasn't discontinued by the medical attendant, notwithstanding chronic obstructive pulmonary disease was known previously in 33 patients.
The Shape of Touch: On‐Body Interfaces for Digital Design and Fabrication (2017)

Like a building to its site, true body architecture must be properly fitted to the specific topography of the wearer's body. Reverb and Tactum are two digital modelling tools developed by Pittsburgh‐based research studio ATONATON for this very purpose. Using projection mapping, depth sensing and gesture recognition, they allow users to physically interact with a virtual design process that links directly through to a 3D‐printed output. Madeline Gannon , the studio's leader, explains how they work.
Prediction of degree of particle misplacement in liquid solid fluidization using artificial neural network (2019)

A predictive model for “misplacement index” and “normalized misplacement index” for predicting particle misplacement has been developed using artificial neural network (ANN). The ANN is having three-layer MLP 7-4-2 architecture. The ANN was trained using Broyden–Fletcher–Goldfarb–Shanno algorithm. The performance of the model was judged by sum of squares error function. The correlation coefficient values of 0.9942 and 0.9657 are achieved for training, dataset for prediction of misplacement index and normalized misplacement index, respectively. It was found that the ANN model developed is highly sensitive to the MPSR and least sensitive to static bed height.
Whole Genome Sequence Analysis of the First Australian OXA-48-Producing Outbreak-Associated Klebsiella pneumoniae Isolates: The Resistome and In Vivo Evolution (2013)

Whole genome sequencing was used to characterize the resistome of intensive care unit (ICU) outbreak-associated carbapenem-resistant K. pneumoniae isolates. Importantly, and of particular concern, the carbapenem-hydrolyzing β-lactamase gene bla(OXA-48) and the extended-spectrum β-lactamase gene bla(CTX-M-14), were identified on a single broad host-range conjugative plasmid. This represents the first report of bla(OXA-48) in Australia and highlights the importance of resistance gene surveillance, as such plasmids can silently spread amongst enterobacterial populations and have the potential to drastically limit treatment options. Furthermore, the in vivo evolution of these isolates was also examined after 18 months of intra-abdominal carriage in a patient that transited through the ICU during the outbreak period. Reflecting the clonality of K. pneumoniae, only 11 single nucleotide polymorphisms (SNPs) were accumulated during this time-period and many of these were associated with genes involved in tolerance/resistance to antibiotics, metals or organic solvents, and transcriptional regulation. Collectively, these SNPs are likely to be associated with changes in virulence (at least to some extent) that have refined the in vivo colonization capacity of the original outbreak isolate.
IATE 2 (2019)

Abstract The redevelopment of the European Union’s interinstitutional terminology database IATE (InterActive Terminology for Europe) has been an opportunity to rethink the technologies, architecture and data structure of the system in order to prepare it for future challenges, including interoperability, modularity, scalability and data exchange, among other things. This article describes which strategies are being put in place to allow IATE data – one of the largest multilingual terminology databases in the world – to be consumed by third-party tools, particularly computer-assisted translation environments (CATEs). The modernisation of the application, aligning it with the latest software and systems engineering standards and technologies for the benefit of all users and for improved data management by EU linguists, is also described.
Hormone-Sensitive Lipase and Neutral Cholesteryl Ester Lipase (2003)

Hormone-sensitive lipase (HSL) catalyzes the rate-limiting step in the hydrolysis of stored triacylglycerols in adipocytes, i.e., the hydrolysis of triacylglycerol to diacylglycerol (for a recent review on HSL, see ref. 1). It also catalyzes the hydrolysis of diacylglycerols and monoacylglycerols. However, a second enzyme, monoglyceride lipase, is required to obtain a complete degradation of monoacylglycerols (2). HSL is most abundantly expressed in adipose tissue, but is also expressed in steroidogenic and muscle tissues (3,4). It has been proposed that the function of HSL in steroidogenic tissues is to hydrolyze stored cholesteryl esters, in order to provide free cholesterol for the synthesis of steroid hormones (5). However, at least with regard to testis, this hypothesis has been questioned by the finding that HSL seems to be expressed in Sertoli cells and spermatids, rather than in the hormone-producing Leydig cells (6,7). In muscle tissues HSL is believed to function as a triglyceride lipase to release fatty acids for oxidation within the tissue. HSL also seems to be expressed in macrophages, at least in murine macrophages, in which several groups clearly have demonstrated the presence of HSL (8–10). The presence of HSL in human macrophages is more questionable, since attempts to demonstrate HSL in these cells have so far been unsuccessful (9). It is speculated that HSL in macrophages functions as a cholesteryl ester lipase in hydrolyzing stored cholesteryl esters in the cytoplasm, i.e., it catalyzes the first step of reverse cholesterol transport.
Monitoring Cell Growth (1997)

This appendix provides two protocols for monitoring cell growth. Counting cells using a hemacytometer is tedious but it allows one to effectively distinguish live cells from dead cells (using Trypan Blue exclusion). In addition, this procedure is less subject to errors due to cell clumping or heterogeneity of cell size. The use of an electronic cell counter is quicker and easier than counting cells using a hemacytometer. However, an electronic cell counter as currently constructed does not distinguish live from dead cells in a reliable fashion and is subject to error due to the presence of cell clumps. Overall, the electronic cell counter is best reserved for repetitive and rapid counting of fresh peripheral blood cells and should be used with caution when counting cell populations derived from tissues.
A 13.56 MHz CMOS RF Identification Passive Tag LSI with Ferroelectric Random Access Memory (2005)

A radio frequency identification tag LSI operating with the carrier frequency of 13.56MHz as well as storing nonvolatile information in embedded ferroelectric random access memory (FeRAM) has been developed. A full wave rectifier composed of PMOS transistor diodes and NMOS transistor switches achieves RF-to-DC power conversion efficiency over 54%. The entire 16 kbits write and read transaction time can be reduced to 2.1 sec by the use of FeRAM, which corresponds to 2.2 times speed enhancement over conventional EEPROM based tag LSIs. The communication range of the FeRAM based tag LSI can be effectively improved by storing antitheft information in a ferroelectric nonvolatile flip-flop, which can reduce the power consumption of FeRAM from 27μW to 5μW. The communication range for the antitheft gate system becomes 70 cm.
In vitro anthelmintic efficacy of inhibitors of phosphoethanolamine Methyltransferases in Haemonchus contortus (2016)

The essential phosphobase methylation pathway for synthesis of phosphocholine is unique to nematodes, protozoa and plants, and thus an attractive antiparasitic molecular target. Herein, we screened compounds from the National Cancer Institute (Developmental Therapeutics Program Open Chemical Repository) for specific inhibitory activity against Haemonchus contortus phosphoethanolamine methyltransferases (HcPMT1 and HcPMT2), and tested candidate compounds for anthelmintic activity against adult and third-stage larvae of H. contortus. We identified compound NSC-641296 with IC50 values of 8.3 ± 1.1 μM and 5.1 ± 1.8 μM for inhibition of the catalytic activity of HcPMT1 alone and HcPMT1/HcPMT2 combination, respectively. Additionally we identified compound NSC-668394 with inhibitory IC50 values of 5.9 ± 0.9 μM and 2.8 ± 0.6 μM for HcPMT1 alone and HcPMT1/HcPMT2 combination, respectively. Of the two compounds, NSC-641296 depicted significant anthelmintic activity against third-stage larvae (IC50 = 15 ± 2.9 μM) and adult stages (IC50 = 7 ± 2.9 μM) of H. contortus, with optimal effective in vitro concentrations being 2-fold and 4-fold, respectively, lower than its cytotoxic IC50 (29 ± 2.1 μM) in a mammalian cell line. Additionally, we identified two compounds, NSC-158011 and NSC-323241, with low inhibitory activity against the combined activity of HcPMT1 and HcPMT2, but both compounds did not show any anthelmintic activity against H. contortus. The identification of NSC-641296 that specifically inhibits a unique biosynthetic pathway in H. contortus and has anthelmintic activity against both larval and adult stages of H. contortus, provides impetus for the development of urgently needed new efficacious anthelmintics to address the prevailing problem of anthelmintic-resistant H. contortus.
Agents enhancing γ‐aminobutyric acid receptor‐coupled chloride ionophore function. Effects in a social interaction model of anxiety in the rat (1990)

Abstract A recently described social interaction (SI) model which is sensitive to single doses of benzodiazepines and novel non‐sedative anxiolytic agents has been used. Activities of drugs were compared in both an anxious (animals housed in pairs, tested with a novel partner) and a non‐anxious (animals housed in pairs, tested with the cage mate) condition. Diazepam displays a typical anxiolytic response, increasing SI in the anxious but not in the non‐anxious condition. This was associated with a decrease in aggression (AGG) and in locomotion (LOCO) at higher doses. Seven agents were tested which are thought to enhance central nervous system γ‐aminobutyric acid (GABA)‐mediated neurotransmission by increasing the activity of a receptor‐coupled chloride ionophore system as a major component of their action. Tracazolate, RL348, methaqualone, etomidate, LY81067, and pentobarbitone all significantly increased SI in the anxious but not the non‐anxious condition. In the anxious condition tracazolate and RL348 reduced AGG and all of these compounds except LY81067 reduced LOCO. Methaqualone and etomidate also reduced LOCO in the non‐anxious condition. In addition, an agent which reduces GABA function (picrotoxin) significantly reduced SI in already‐anxious animals, consistent with its known anxiogenic properties. Picrotoxin also reduced LOCO in both conditions. Phenobarbitone induced a non‐specific effect on SI (increased SI in both anxious and non‐anxious conditions), as well as reducing AGG in the anxious condition and LOCO in both conditions. These data suggest that agents enhancing GABA receptor‐coupled chloride ionophore function possess anxiolytic properties which may be attributed to this activity.
ChemInform Abstract: Status of Advanced Carbide Fuels: Past, Present, and Future. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Catalytic Functionalities of Supported Sulfides III. Correlation of activities at Elevated Pressure with Oxygen Chemisorption (1984)

Abstract A number of different supported CoMo catalysts, that had been characterized by O 2 chemisorption measurements, were evaluated for hydrodesulfurization of dibenzothiophene, hydrogenation of naphthalene, and C‐N‐bond hydrogenolysis of indole at elevated pressure. Only rough correlations between the different catalyst functionalities, and between the functionalities and O 2 chemisorption, were obtained. It is concluded that different active sites are involved for the different reactions, and that O 2 chemisorption is generally related to the dispersion of the active MoS 2 phase rather than to any specific reaction site.
The Iterative Data Cube (2000)

. Data cubes provide aggregate information to support the analysis of the contents of data warehouses and databases. An important tool to analyze data in data cubes is the range query. For range queries that summarize large regions of massive data cubes, computing the query result on-the-fly can result in non-interactive response times (e.g. in the order of minutes). To speed up range queries, values that summarize regions of the data cube are pre-computed and stored. This faster response time results in more expensive updates and/or space overhead. In this paper a technique is presented that generates a new class of schemes that support range queries on data cubes -- Iterative Data Cubes. The main idea is that techniques that provide a certain tradeoff of query and update costs for a one-dimensional data cube are applied iteratively along the dimensions of data cubes of higher dimensionality. The different one-dimensional techniques can be combined, resulting in a great vari...
Breaking the Barrier of Flow Simulation: Well Placement Design Optimization with Fast Marching Method and Geometric Pressure Approximation (2017)

Abstract This paper presents the implementation of a novel approach for efficient well placement design based on the dynamic characteristic of the reservoir without the need to run flow simulation. The approach uses State-of-the-Art Technology called the Fast Marching Method (FMM) coupled with Geometric Pressure Approximation to define a Dynamic Reservoir Quality Map. This map is also referred to as the Depletion Capacity (DC) Map. It provides the mapping of future potential locations to further deplete the reservoir. The DC Map is generated by calculating 4 important factors, namely Pore Volume, Mobility of the Hydrocarbon, Reservoir Energy, and the Undrained Volume of the reservoir. The major breakthrough in using this technology is the ability to estimate the pressure distribution (i.e., reservoir energy) and drainage volume (i.e., to estimate the undrained volume) efficiently. These are the 2 factors that are difficult to obtain without conducting traditional flow simulation. The two aforementioned factors were obtained by calculating the FMM diffusive time of flight which can be related to the pressure drop by the Geometric Pressure Approximation theory. Thus, in effect, this calculation represents a pseudo-simulation, which is orders of magnitude faster than conventional simulation. The technique is applicable for both fine scale and coarse scale models with large number of realizations representing geological uncertainties. This approach works well in capturing the primary depletion phenomenon. In this paper, we demonstrate the evaluation of existing well placement of an actual developed field, with 16 wells, located in Tarim Basin, West China, by comparing it to a new design. Additionally, the method is also used to propose future locations for infill drilling. The study is motivated by the big challenges faced when drilling a well at a depth between 6800 m–8000 m. Optimum well placement has the potential to drill optimum number of wells to produce the same reserves. The new design was created with a scenario where 5 exploration wells that been put into production for a couple of years to represent the early depleted condition. The results show the optimum design can be achieved with only 12 wells. A saving of 4 wells compared to the existing well pattern. This is a significant saving considering the drilling challenges. For the infill drilling, the study shows that for this reservoir, adding more wells may not be beneficial from the ultimate recovery point of view but production can be accelerated by drilling up to 2 more wells at the best potential locations as suggested by the DC Map. Best of all, the proposed method optimizes the locations very quickly.
The N-terminal sequence of the large proteoglycan of articular cartilage. (1990)

A peptide with hyaluronic acid-binding properties was isolated from trypsin digests of bovine articular cartilage proteoglycan aggregate. This peptide originated from the N-terminus of the proteoglycan core protein, retained its function of forming complexes with hyaluronate and link protein and contained at least one keratan sulfate chain. Amino acid sequence data demonstrated that the first six amino acid residues of the N-terminus of bovine articular cartilage proteoglycan core protein differed from the same region from the rat chondrosarcoma proteoglycan. Further sequence data indicate areas of considerable sequence homology in the hyaluronic acid-binding regions of proteoglycans from the two species.
TDP43-Mediated Microglial Activation through NF-κB, AP-1 and NLRP3 Inflammasome (P02.172) (2013)

OBJECTIVE: To define the effects of TDP43 on microglia and whether they contribute to the underlying mechanisms of neurotoxicity in amyotrophic lateral sclerosis (ALS).
Letters to the Editor (1993)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Point mutations in IMPDH2 which cause early-onset neurodevelopmental disorders disrupt enzyme regulation and filament structure (2023)

Inosine 5' monophosphate dehydrogenase (IMPDH) is a critical regulatory enzyme in purine nucleotide biosynthesis that is inhibited by the downstream product GTP. Multiple point mutations in the human isoform IMPDH2 have recently been associated with dystonia and other neurodevelopmental disorders, but the effect of the mutations on enzyme function has not been described. Here, we report identification of two additional affected individuals with missense variants in <i>IMPDH2</i> and show that all of the disease-associated mutations disrupt GTP regulation. Cryo-EM structures of one IMPDH2 mutant suggest this regulatory defect arises from a shift in the conformational equilibrium toward a more active state. This structural and functional analysis provides insight into IMPDH2-associated disease mechanisms that point to potential therapeutic approaches and raises new questions about fundamental aspects of IMPDH regulation.
On the effective medium theory of subwavelength periodic structures (1996)

Abstract The effective medium theory of one-dimensional and two-dimensional periodic structures are investigated. A method based on a Fourier decomposition of the wave propagating along the direction perpendicular to the periodic structures allows one to determine the zeroth-, first- and second-order effective indices. For one-dimensional problems, we derive closed-form expressions of the effective indices for both TE and TM polarization. Our result can be applied to arbitrary periodic structure with symmetric or non-symmetric lamellar or continuously varying index profiles. The theoretical predictions are carefully validated using rigorous coupled-wave analysis. For the two-dimensional case, only symmetric structures are discussed and the computation of the zeroth-, first-, and second-order effective indices requires the inversion of an infinite matrix which can be truncated and simply solved numerically. The EMT prediction is qualitatively validated using rigorous computation for small period-to-wavelength ratios. It is shown that for large period-to-wavelength ratios near the cutoff value, no analogy between 2-D periodic structures and homogeneous media holds for highly modulated lamellar gratings.
Numerical modeling of the minimum priming charge test (1980)

The minimum priming charge test is modeled in one-dimensional symmetry using the SIN hydrodynamic code and the Forest Fire decomposition rate model. Calculated and experimental values of the minimum priming charge for PBX 9404 and Comp. B are compared. The sensitivity of the calculations to the Pop plot input for the Forest Fire decomposition rates and to the Extex booster charge equation of state is examined.
Discrete Domain Analysis of Delayed Resonator (1996)

Abstract The Delayed Resonator (DR) is a new active vibration absorption technique which uses time delayed partial state feedback to generate ideal resonance on a passive vibration absorber. It has many attractive features such as real-time tunability, ease of implementation and total suppression of vibration for tonal frequency disturbances. The DR controller has been developed in continuous domain until now. In this paper discrete domain analysis is presented. Simulation results indicate an expected dependency of stability on the sampling period for this active control strategy. A major advantage of discrete domain analysis is the reduction of characteristic roots from infinite to finite numbers and consequent simplicity in the analysis and design of the controller. It is shown that discrete domain control design for DR yields better vibration suppression considering the sampled control structure in implementations.
20.1: Microcup® Active and Passive Matrix Electrophoretic Displays by Roll‐to‐Roll Manufacturing Processes (2003)

Abstract Rolls of flexible electrophoretic panels have been prepared by the SiPix roll‐to‐roll manufacturing process based on novel Microcup® and top‐sealing technologies. The resultant Microcup® passive matrix electrophoretic displays (PMEPDs) and a‐Si TFT active matrix electrophoretic displays (AMEPDs) have shown outstanding contrast ratio, switching rate, image bistability, threshold characteristics, grayscale capability, operation temperature latitude, and physicomechanical properties.
Photodimerization of some cyclopropenes (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotodimerization of some cyclopropenesCharles D. DeBoer, Donald H. Wadsworth, and William C. PerkinsCite this: J. Am. Chem. Soc. 1973, 95, 3, 861–869Publication Date (Print):February 1, 1973Publication History Published online1 May 2002Published inissue 1 February 1973https://pubs.acs.org/doi/10.1021/ja00784a039https://doi.org/10.1021/ja00784a039research-articleACS PublicationsRequest reuse permissionsArticle Views228Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts