gebhart/patrepeval huggingface dataset:
Abstract P019: Intra-tumoral nerves regulate the local immune response at the tumor bed (2022)

Abstract Patients with highly innervated tumors have a worse prognosis than those with less innervated disease. However, the process by which intra-tumoral nerves contribute to poor outcomes remains unclear. Previously, we identified that head and neck squamous cell carcinomas (HNSCCs) are infiltrated by sensory (TRPV1+) nerves. To map the source of these tumor infiltrating nerves, we intra-tumorally injected the fluorescently tagged nerve tracer lectin, wheat germ agglutinin (WGA), in our hind limb placed HNSCC tumors. Similar to other nerve tracers, WGA is taken up at nerve terminals and retrogradely transported to the neural somas. WGA labeled the somas of dorsal root ganglia (DRG), identifying them as the source of intra-tumoral nerves. Traced nerves were further characterized by immunostaining and identified as TRPV1+ (sensory), consistent with our initial findings. To test the contributions of tumor innervation to tumor growth and survival, wildtype and TRPV1-DTA (genetically deleted of TRPV1+ neurons) mice were implanted with a mouse model of human papillomavirus-induced (HPV+) HNSCC, mEERL cells. The absence of TRPV1 nerves results in slower tumor growth and improves survival. To mechanistically define how depletion of intra-tumoral nerves reduce tumor growth, we first collected tumors 25 days after injection in the hind limb and stained with a 12-color antibody panel. Stained tumors were then analyzed with flow cytometry to identify differences in the infiltrative immune cell populations between tumors grown in C57Bl/6 control mice and our TRPV1-DTA mouse model. Flow cytometry analysis indicated a decrease in the infiltrative myeloid derived suppressor cell (MDSC) population following ablation of TRPV1+ nerves. To understand how loss of TRPV1+ nerves mediate changes in the infiltrative immune cell population we conducted cytokine array analysis of condition media from cancer cells alone and in co-culture with DRG. Results indicate a shift in secreted cytokines following co-culture with DRG. These data indicate that intra-tumoral sensory nerves are recruited from loco-regional DRG to tumors injected in the hind limb. Our data also suggest that ablation of TRPV1+ nerves alter the intra-tumoral MDSC population and, in this way, potentially contributes to tumor growth. Finally, co-culture of mEERL cells with DRG in vitro results in changes in secreted cytokines, potentially explaining the change in the infiltrative immune cell populations. Together, these data indicate a potential role for sensory nerves to regulate the local immune response in developing tumors. Citation Format: Anthony C. Restaino, Christopher T. Lucido, Jeffrey Barr, Paola D. Vermeer. Intra-tumoral nerves regulate the local immune response at the tumor bed [abstract]. In: Abstracts: AACR Virtual Special Conference: Tumor Immunology and Immunotherapy; 2021 Oct 5-6. Philadelphia (PA): AACR; Cancer Immunol Res 2022;10(1 Suppl):Abstract nr P019.
An aspect-oriented approach to business process modeling (2009)

Traditional methods to business process modeling build the model in a unified way, which gives rise to complex models, where different concerns are scattered and tangled. In this paper we propose the use of an aspect-oriented approach to modularize business process modeling. We propose a meta Aspect Oriented Process Modeling Language (AOPML) that is independent of any specific business process language. In order to show the applicability of the approach we instantiate it using the Business Process Model Notation (BPMN) in a case study that takes advantage of AOPML.
Ship Rolling Sequence Prediction Based on RBF-NAR Model (2011)

The linear auto regression (AR) model used for predict ships' movement, which with strong nonlinear characteristics, can not meet the precision need. To enhance the ship's seaworthiness capacity, a new prediction algorithm based on nonlinear auto regression model is presented to forecast roll motion accurately. The state-dependent autoregressive(SDAR) model and RBF(radial basis function) network are introduced firstly, then using RBF to map the functional coefficients of SDAR model, and the structure of the nonlinear parameter optimization method(SNPOM) is adopted to optimize parameters. The new model named RBF-NAR model, which has nonlinear approximation ability and auto regression characteristics, is applied to predict ships' rolling sequence. The comparison between AR and RBF-NAR of same order shows that higher accuracy can be achieved by the later one. Further more, RBFNAR costs less time than pure RBF network prediction with same precision requirement. The simulation results prove that the new model is more accurate and stabilizer than tradition models.
Multi-agent Based Architecture for Dynamic VM Consolidation in Cloud Data Centers (2014)

As the scale of cloud data centers becomes larger and larger, the energy consumption of data centers also grows rapidly. Dynamic consolidation of Virtual Machines (VMs) presents a significant opportunity to save energy by turning off idle or under-utilized Physical Machines (PMs) in data centers. In this paper, we present a multi-agent based architecture for performing dynamic VM consolidation task. The architecture uses a local agent in each PM to decide when a PM becomes overloaded using reinforcement learning approach. Moreover, a global agent is proposed as a supervisor to dynamically optimize the VM placement based on the local agents' decisions. Therefore, agents cooperate together to minimize the number of active PMs according to the current resource requirements. Experimental results on the real workload traces from more than a thousand Planet Lab virtual machines show that the proposed architecture can reduce the energy consumption and maintains the required performance level in a large-scale data center.
(Tetrathiafulvalene)bis(acetylacetonato)palladium(II), (TTF)Pd(acac)2, a metallotetrathiaethylene containing neutral tetrathiafulvalene (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT(Tetrathiafulvalene)bis(acetylacetonato)palladium(II), (TTF)Pd(acac)2, a metallotetrathiaethylene containing neutral tetrathiafulvaleneA. R. Siedle, T. J. Kistenmacher, R. M. Metzger, Chiun-Shiung Kuo, R. P. Van Duyne, and T. CapeCite this: Inorg. Chem. 1980, 19, 7, 2048–2051Publication Date (Print):July 1, 1980Publication History Published online1 May 2002Published inissue 1 July 1980https://pubs.acs.org/doi/10.1021/ic50209a042https://doi.org/10.1021/ic50209a042research-articleACS PublicationsRequest reuse permissionsArticle Views166Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Factors Affecting Blood Loss During Percutaneous Nephrolithotomy Using Balloon Dilation in a Large Contemporary Series (2009)

We report a comparable stone-free rate and a lower incidence of blood transfusion among patients undergoing PNL using balloon dilation.
The Exponentially Weighted Moving Variance (1993)

Exponentially weighted moving variance (EWMV) and exponentially weighted mean squared deviation (EWMS) charts are proposed as ways of monitoring various types of continuous process variation. They are particularly useful for augmenting control charts on individual observations where no estimate of variability is available from replicates and for providing measures of process variance when the observations are autocorrelated.
In-vivo corneal biomechanical analysis of unilateral keratoconus. (2015)

Ocular response analyzer parameters (CH and CRF) are found to be significantly lower in forme fruste keratoconus patients compared to normal control subjects.
Seismic Retrofitting of RC Frames with RC Infilling (SERFIN Project)SERIES Transnational Access report (2013)

The effectiveness of seismic retrofitting of multi-storey multi-bay RC-frame buildings by converting selected bays into new walls through infilling with reinforced concrete (RC) was studied experimentally at the ELSA facility of the Joint Research Centre in Ispra (Italy). A full-scale model was tested with the pseudo-dynamic method and consisted of two four-storey (12m tall) three-bay (8.5m long) parallel frames linked through 0.15m slabs with the central bay (2.5m) infilled with a RC wall. The frames were designed and detailed for gravity loads only and are typical of similar frames built in Cyprus in the 1970’s. \n\nDifferent connection details and reinforcement percentages for the two infilled frames were used in order to study their effects in determining structural response. The results of the pseudo-dynamic and cyclic tests performed on the specimen with the new walls show five times higher resistance to earthquake loads when compared to typical building construction in Cyprus in the 1970's.
In the heart of the Hausa states (1990)

Consequent upon the Berlin West Africa Conference (1884-1885), the Africanische Gesellschaft in Deutschland launched the Niger-Benue expedition to investigate possible riverine communications throughout the Niger-Benue river system. Responsibility for the expedition ultimately fell to Paul Staudinger, a young entomologist with no experience of inner Africa. This translation of Staudinger's Im Herzen der Haussalander opens up an invaluable source book of interest not only to the historian but to specialists in many disciplines. It deals with every aspect of the life of the Hausa-Fulani people: their history, environment, flora and fauna, culture, economy, and social structure as observed by a patriotic young German scientist of a century ago. The chronological narrative of the journey is followed by a series of appendices, each providing a systematic summary of a particular branch of knowledge. Foreword by Paul Lovejoy.
Study of CFD Variation on Transport Configurations from the Second Drag-Prediction Workshop (2004)

This paper describes and analyzes a series of nearly 90 CFD test cases performed as a contribution to the second Drag Prediction Workshop, held in association with the AIAA in June 2003. Two configurations are included: DLR-F6 wing-body and wing-body-nacelle-pylon. The ability of CFD to predict the drag, lift, and pitching moment from experiment-including the arising from the addition of the nacelle and pylon-is assessed. In general, at a fixed angle of attack CFD overpredicts lift, but predicts the delta C (sub L) reasonably well. At low lift levels (C (sub L) less than 0.3)), delta C (sub D) is 20-30 drag counts (30-45%) high. At the target lift coefficient of C(sub L) = 0.5, delta C (sub D) is overpredicted by between 11-16 counts. However, the primary contribution of this paper is mot so much the assessment of CFD against experiment, but rather a detailed assessment and analysis of CFD variation. The series of test cases are designed to determine the sensitivity/variability of CFD to a variety of factors, including grid, turbulence model, transition code, and viscous model. Using medium-level grids (6-11 million points) at the target lift coefficient, the maximum variation in drag due to different grids is 5-11 drag counts, due to code is 5-10 counts, due to turbulence model is 7-15 counts, due to transition is 10-11 counts, and due to viscous model is 4-5 counts. Other specific variations are described in the paper.
Discontinuous control and simultaneous identification of distributed parameter systems (2003)

Presents discontinuous control laws for distributed parameter systems of parabolic and hyperbolic types which yield asymptotic tracking of the output of a reference model. The use of the discontinuity in these control laws permits rejection of input disturbances and ensures robustness with respect to dynamic uncertainties, both with the a priori known norm bounds. It is also demonstrated that unknown plant parameters could be simultaneously identified pointwise through the construction of the auxiliary system. Under the persistently exciting reference input, the time-varying parameters of the auxiliary system converge to plant parameters in L/sub 2/ and the orthogonal expansions of the former obtained by passing them through the integrator block converge to plant parameters pointwise.
A New PhaseLocked Loop Timing Recovery Method for Digital Regenerators (2009)

Timing can be extracted at low cost from a random baseband digital data signal by locking a local oscillator to the reshaped bit streac. To avoid use of a very stable oscillator, a narrowband phase-locked loop is forced to synchronize to the scrambled but otherise unrestricted data by means of an auxiliary frequency sensitive loop. The novel comparator vhich can measure the phase and frequency difference between a local oscillator and a random data signal is described. The method is simple to implement even at high frequency, synchronizes rapidly, and has excellent acquisition and jitter control performance when operated in a cascade of regenerators. A loop with an acquisition range of greater than ??20 percent of the data rate and 0.1 percent noise bandvidth has been demonstrated.
Functional Organization of the Maternal and Paternal Human 4D Nucleome (2020)

Abstract Every human somatic cell inherits a maternal and a paternal genome, which work together to give rise to cellular phenotypes. However, the allele-specific relationship between gene expression and genome structure through the cell cycle is largely unknown. By integrating haplotype-resolved genome-wide chromosome conformation capture, mature and nascent mRNA, and protein binding data, we investigate this relationship both globally and locally. We introduce the maternal and paternal 4D Nucleome, enabling detailed analysis of the mechanisms and dynamics of genome structure and gene function for diploid organisms. Our analyses find significant coordination between allelic expression biases and local genome conformation, and notably absent expression bias in universally essential cell cycle and glycolysis genes. We propose a model in which coordinated biallelic expression reflects prioritized preservation of essential gene sets.
Micellar Solution of Sodium Dodecyl Sulfate (SDS) Catalyzes Facile Michael Addition of Amines and Thiols to α,β‐Unsaturated Ketones in Water under Neutral Conditions (2005)

Abstract Sodium dodecyl sulfate (SDS) catalyzes facile Michael additions of amines and thiols to α ,β ‐unsaturated ketones under neutral micellar conditions to afford the corresponding Michael adducts in good to high yields.
Proliferation of Human Neuroblastomas Mediated by the Epidermal Growth Factor Receptor (2005)

Neuroblastoma is a common solid tumor of childhood that is derived from the neural crest. Expression of epidermal growth factor (EGF) receptors (EGFRs) has been associated with enhanced cell growth and aggressive behavior in other tumors. Here, we examined the expression profile of EGFRs in neuroblastoma cell lines and primary tumors. We found that all 13 neuroblastoma cell lines examined expressed EGFR1 (HER1), most at readily detectable levels. Low levels of other human EGFR family receptors were also detected in almost all cell lines. All primary tumors examined expressed readily detectable levels of HER1 and HER3 and lower levels of HER2 and HER4. EGF had a significant effect on the proliferation of neuroblastoma cell lines in vitro. EGF treatment (100 ng/mL) of the cell lines SY5Y and NLF significantly increased cell number (P < 0.01). EGF stimulated more cells to enter S and G2-M phase, as suggested by flow cytometry, indicating that EGF increases cell number by increasing proliferation, with no appreciable change in apoptosis. EGF exposure resulted in receptor autophosphorylation and activation of both the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT pathways. Exposure to 0.5 micromol/L ZD1839, a HER1-specific inhibitor, caused a 40% to 50% reduction in the number of SY5Y and NLF cells grown in medium containing 10% fetal bovine serum (P < 0.01). Even at 0.01 micromol/L, ZD1839 inhibited autophosphorylation of HER1 by EGF. At 0.1 micromol/L, it also blocked phosphorylation of AKT, but not MAPK, in NLF cells. Additional studies showed that the PI3K/AKT-specific inhibitor LY294002 had a more profound effect than the MAPK-specific inhibitor U0126 in blocking EGF-induced cell proliferation. This suggests that the PI3K/AKT pathway is the main signaling pathway responsible for the proliferation effects of EGF in neuroblastomas. Our results also indicate that ZD1839 is a potent inhibitor of neuroblastoma cell proliferation; therefore, it may be a useful, biologically based therapeutic agent for these tumors.
Reconstruction 3D biplanaire non supervisée de la colonne vertébrale et de la cage thoracique scoliotiques par modèles statistiques (2004)

Cette thèse présente trois approches statistiques pour la reconstruction 3D de la colonne vertébrale et de la cage thoracique scoliotiques à partir de deux images radiographiques conventionnelles. Globalement, les méthodes sont basées sur l'utilisation de contours de vertèbres ou des côtes détectées dans deux images radiographiques et une connaissance géométrique a priori de nature statistique de chaque élément. La reconstruction est formulée comme un problème de minimisation de fonctions d'énergie résolues par des méthodes d'optimisation. Pour la colonne vertébrale, les méthodes sont validées par comparaison avec des reconstructions de 57 vertèbres scoliotiques reconstruites à partir d'images tomodensitométriques. Plusieurs méthodes ont été proposées afin de raffiner les solutions obtenues et de rendre les méthodes non supervisées.
Les adipokines MIF et MFG-E8 utilisent les vésicules extracellulaires comme voie de sécrétion (2018)

International audience
Growth and Self-assembly of Nanostructured CoC2O4·2H2O Particles (2004)

The growth of CoC2O4·2H2O particles during aqueous precipitation has been followed by several electron microscopy techniques. A multiple-stage growth leading to final particles with a core−shell structure has been observed. In the first stage, the primary particles grow and aggregate to form secondary particles which in turn agglomerate to form the elongated core of the final particles. The final particle crystal faces are formed around the core, layer by layer and face by face, by primary particle self-assembly. The core is disordered and composed of both isolated partially crystalline primary particles and aggregated primary particles. The shell faces are ordered and made up by assembly of strings of 5−7 nm crystalline nanodomains.
A Theory of Post-Stall Transients in Axial Compression Systems: Part II—Application (1986)

Using the theory developed in Part I, calculations have been carried out to show the evolution of the mass flow, pressure rise, and rotating-stall cell amplitude during compression system post-stall transients. In particular, it is shown that the unsteady growth or decay of the stall cell can have a significant effect on the instantaneous compressor pumping characteristic and hence on the overall system behavior. A limited parametric study is carried out to illustrate the impact of different system features on transient behavior. It is shown, for example, that the ultimate mode of system response, surge or stable rotating stall, depends not only on the B parameter, but also on the compressor length-to-radius ratio. Small values of the latter quantity tend to favor the occurrence of surge, as do large values of B. Based on the analytical and numerical results, some specific topics are suggested for future research on post-stall transients.
A Three-Dimensional, Magnetic and Electroactive Nanoprobe for Amperometric Determination of Tumor Biomarkers (2011)

A novel electrochemical immunosensor for tumor biomarker detection based on three-dimensional, magnetic and electroactive nanoprobes was developed in this study. To fabricate the nanoprobes, negatively charged Fe(3)O(4) nanoparticles (Fe(3)O(4) NPs) and gold nanoparticles (Au NPs) were first loaded on the surface of multiple wall carbon nanotubes (MCNTs) which were functioned with redox-active hemin and cationic polyelectrolyte poly(dimethyldiallylammonium chloride) (PDDA). Using alpha fetoprotein (AFP) as a model analyte, AFP antibody (anti-AFP) was absorbed on the surface of Au NPs, bovine serum albumin (BSA) was then used to block sites against non-specific binding, and finally formed anti-AFP/Au NPs/Fe(3)O(4)/hemin/MCNTs named anti-AFP nanoprobes. When the target antigen AFP was present, it interacted with anti-AFP and formed an antigen-antibody complex on the nanoprobe interface. This resulted in a decreased electrochemical signal of hemin for quantitative determination of AFP when immobilized onto the screen-printed working electrode (SPCE). The results showed that the nanoprobe-based electrochemical immunosensor was sensitive to AFP detection at a concentration of 0.1 to 200 ng·mL(-1) with a detection limit of 0.04 ng·mL(-1), it also demonstrated good selectivity against other interferential substances. The electroactive nanoprobes can be massively prepared, easily immobilized on the SPCE for target detection and rapidly renewed with a magnet. The proposed immunosensor is fast, simple, sensitive, stable, magnet-controlled, nontoxic, label-free and reproducible.
Development of a high-throughput screening assay for inhibitors of the integrase-transportin-SR2 interaction (2015)

status: Published
Leaving Your Legacy: You Don't Need to Win a Nobel Prize to Inspire the Next Generation (2019)

Let's teach our girls it's not about being beautiful! Teach them to be bold. Be authentic. Be strong. Be confident. Be independent and demonstrate their intelligence. Be brave. Be proud. Be real and take ownership of their future!. It is a widely known and highly concerning fact that women remain underrepresented in the science and engineering workforce. This gender imbalance is not as severe as it once was, but wide disparities remain, especially in engineering, computer science, and the physical sciences. The under representation of women in science classes and in science, technology, engineering, and math (STEM) careers continues to be a compelling and puzzling issue. Female scientists and engineers are concentrated in different occupations than men, with relatively high rates of women in the social sciences (60%) and in biological, agricultural, and environmental life sciences (48%). Meanwhile, rates of women are relatively low in engineering (15%) and computer and mathematical sciences (26%) [1]. Women make up half of the total U.S. college -educated workforce but only 28% of the science and engineering workforce. It is critically important that girls see STEM as interesting, engaging, and a discipline worth considering when planning for college and beyond. Competence is an important part of intrinsic motivation for females. Girls have been shown to care more than boys about the applications of the science they are learning [6]. Their preference for science in context makes it a good practice to introduce ideas about why a particular area of science is relevant in daily life before getting into complicated, and perhaps difficult, technicalities. Educators must keep science concepts relevant, flexible, and adaptable to ignite curiosity in girls.