gebhart/patrepeval huggingface dataset:
Neural Coding Mechanisms Underlying Perceived Roughness of Finely Textured Surfaces (2001)

Combined psychophysical and neurophysiological studies have shown that the perceived roughness of surfaces with element spacings of >1 mm is based on spatial variation in the firing rates of slowly adapting type 1 (SA1) afferents (mean absolute difference in firing rates between SA1 afferents with receptive fields separated by approximately 2 mm). The question addressed here is whether this mechanism accounts for the perceived roughness of surfaces with element spacings of <1 mm. Twenty triangular and trapezoidal gratings plus a smooth surface were used as stimulus patterns [spatial periods, 0.1-2.0 mm; groove widths (GWs), 0.1-2.0 mm; and ridge widths (RWs), 0-1.0 mm]. In the human psychophysical studies, we found that the following equation described the mean roughness magnitude estimates of the subjects accurately (0.99 correlation): 0.2 + 1.6GW - 0.5RW - 0.25GW(2). In the neurophysiological studies, these surfaces were scanned across the receptive fields of SA1, rapidly adapting, and Pacinian (PC) afferents, innervating the glabrous skin of anesthetized macaque monkeys. SA1 spatial variation was highly correlated (0.97) with human roughness judgments. There was no consistent relationship between PC responses and roughness judgments; PC afferents responded strongly and almost equally to all of the patterns. Spatial variation in SA1 firing rates is the only neural code that accounts for the perceived roughness of surfaces with finely and coarsely spaced elements. When surface elements are widely spaced, the spatial variation in firing rates is determined primarily by the surface pattern; when the elements are finely spaced, the variation in firing rates between SA1 afferents is determined by stochastic variation in spike rates.
Breakdown of the Stokes–Einstein relationship and rapid structural ordering in CuZrAl metallic glass-forming liquids (2021)

The results of a combined structural and dynamical study of Cu-Zr-Al metallic glass forming liquids are presented. Containerless high-energy x-ray scattering experiments made using electrostatic levitation are combined with molecular dynamics simulations to probe the onset of rapid structural ordering as well as the temperature-dependent diffusivity and viscosity in three liquids: Cu<sub>49</sub>Zr<sub>45</sub>Al<sub>6</sub>, Cu<sub>47</sub>Zr<sub>45</sub>Al<sub>8</sub>, and Cu<sub>43</sub>Zr<sub>45</sub>Al<sub>12</sub>. These compositions were chosen because they are reported to have dramatically different glass forming-ability. Experimental data show that the first peak in the x-ray static structure factor displays evidence for a Curie-Weiss type behavior, but also a peak in the effective Curie temperature. The evidence provided here for the onset of cooperativity, marked by a crossover temperature, T<sub>A</sub> (which is usually above the liquidus temperature), is accompanied by the onset of development of more spatially extended structural order in the liquids. Based on the molecular dynamics simulations, each of the liquids exhibits a clear breakdown of the Stokes-Einstein relation at a temperature near, but below, the crossover temperature, T<sub>A</sub>. The breakdown is manifest as a rapid reduction in the relative diffusion coefficients between Cu, Zr, and Al.
Cosmic Ray Energy Spectrum measured by the TALE Fluorescence Detector (2021)

The Telescope Array (TA) cosmic rays detector located in the State of Utah in the United States is the largest ultra high energy cosmic rays detector in the northern hemisphere. The Telescope Array Low Energy Extension (TALE) fluorescence detector (FD) was added to TA in order to lower the detector's energy threshold, and has succeeded in measuring the cosmic rays energy spectrum down to PeV energies, by making use of the direct Cherenkov light produced by air showers. In this contribution we present the results of a measurement of the cosmic-ray energy spectrum using TALE FD data collected over a period of $\sim$7 years. The data set used for this measurement is the same one used for the mass composition measurement that is presented, as a separate contribution, at this conference. The energy spectrum shows features consistent with the "knee" and the "second knee"; a similar result to our previous energy spectrum publication. This time using a different hadronic model, and different event selection criteria as explained in the text of this proceeding.
Esterase Active in Polar Organic Solvents from the YeastPseudozymasp. NII 08165 (2014)

Esterases/lipases active in water miscible solvents are highly desired in biocatalysis where substrate solubility is limited and also when the solvent is desired as an acyl acceptor in transesterification reactions, as with the case of biodiesel production. We have isolated an esterase from the glycolipid producing yeast-Pseudozyma sp. NII 08165 which in its crude form was alkali active, thermo stable, halo tolerant and also capable of acting in presence of high methanol concentration. The crude enzyme which maintained 90% of its original activity after being treated at 70°C was purified and the properties were characterized. The partially purified esterase preparation had temperature and pH optima of 60°C and 8.0 respectively. The enzyme retained almost complete activity in presence of 25% methanol and 80% activity in the same strength of ethanol. Conditions of enzyme production were optimized, which lead to 9 fold increase in the esterase yield. One of the isoforms of the enzyme LIP1 was purified to homogeneity and characterized. Purified LIP1 had a K m and V max of 0.01 and 1.12, respectively. The purified esterase lost its thermo and halo tolerance but interestingly, retained 97% activity in methanol.
Effect of Sex Steroids on Babesia microti Infection in Mice (2012)

Sex-based-differences are known to affect susceptibility to protozoan infections, but their effects on parasitemia and clinical symptoms in Babesia infections remain unclear. We examined the sex-based susceptibility of various mouse strains to Babesia microti Munich strain infection. In all strains, male mice exhibited significantly higher peak parasitemia and more severe anemia than female mice. Testosterone and estradiol-17β treatment caused an increase in parasitemia and aggravation of anemia. Orchidectomized male mice receiving testosterone exhibited smaller splenic macrophage populations three days after infection, smaller B cell populations 10 days after infection, and reduced splenic tumor necrosis factor-α and interferon-γ mRNA expression than mice that did not receive testosterone. Mice receiving estradiol-17β did not exhibit immunosuppressive effects. Thus, a weakened and delayed innate immunity response may lead to acquired immunity failure. The results suggested that testosterone directly affects T or B cells, leading to delayed acquired immunity, dramatically increased parasitemia, and severe anemia.
Castellano and Pastor-Satorras Reply: (2007)

The Comment by Ha et al. [cond-mat/0603787] criticizes our recent result [Phys. Rev. Lett. 96, 038701 (2006)] that the contact process (CP) on uncorrelated scale-free (SF) networks does not behave according to heterogeneous mean-field (MF) theory. This claim is based in Gaussian ansatz that reproduces previously reported density fluctuations and numerical simulations for a particular value of the degree exponent $\gamma$ that seem to fit the MF prediction for the density decay exponent $\theta$ and a conjecture of the authors of the comment for the finite-size scaling exponente $\alpha=\beta/ \nu_\perp$. By means of extensive simulations of the CP on random neighbors (RN) SF networks we show that the MF prediction for $\theta4 is incorrect for small degree exponents, while the author's conjecture for $\alpha$ is at best only approximately valid for the unphysical case of uncorrelated networks with cut-off $k_c \sim N^{1/(\gamma-1)}$, which can only be constructed in the RN version of SF networks. Therefore, the main conclusion of our paper [Phys. Rev. Lett. 96, 038701 (2006)], the invalidity of MF theory for real uncorrelated SF networks, remains unchallenged.
Semantic web support for the business-to-business e-commerce lifecycle (2002)

If an e-services approach to electronic commerce is to become widespread, standardisation of ontologies, message content and message protocols will be necessary. In this paper, we present a lifecycle of a business-to-business e-commerce interaction, and show how the Semantic Web can support a service description language that can be used throughout this lifecycle. By using DAML, we develop a service description language sufficiently expressive and flexible to be used not only in advertisements, but also in matchmaking queries, negotiation proposals and agreements. We also identify which operations must be carried out on this description language if the B2B lifecycle is to be fully supported. We do not propose specific standard protocols, but instead argue that our operators are able to support a wide variety of interaction protocols, and so will be fundamental irrespective of which protocols are finally adopted.
Syntheses of Certain 2-Acetamido- 2-deoxy-O-(l-rhamnopyranosyl)-d-glucopyranoses (1987)

Journal Article Syntheses of Certain 2-Acetamido- 2-deoxy-O-(l-rhamnopyranosyl)-d-glucopyranoses Get access Shintaro Kamiya, Shintaro Kamiya Food Chemistry laboratory, Shizuoka Women’s University, Shizuoka 422, Japan Search for other works by this author on: Oxford Academic Google Scholar Sachiko Esaki, Sachiko Esaki Food Chemistry laboratory, Shizuoka Women’s University, Shizuoka 422, Japan Search for other works by this author on: Oxford Academic Google Scholar Naoko Shiba Naoko Shiba Food Chemistry laboratory, Shizuoka Women’s University, Shizuoka 422, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 51, Issue 4, 1 April 1987, Pages 1195–1197, https://doi.org/10.1080/00021369.1987.10868144 Published: 01 April 1987 Article history Received: 31 October 1986 Published: 01 April 1987
Estimating the biodiversity of terrestrial invertebrates on a forested island using DNA barcodes and metabarcoding data (2019)

Invertebrates are a major component of terrestrial ecosystems, however, estimating their biodiversity is challenging. We compiled an inventory of invertebrate biodiversity along an elevation gradient on the temperate forested island of Hauturu, New Zealand, by DNA barcoding of specimens obtained from leaf litter samples and pitfall traps. We compared the barcodes and biodiversity estimates from this data set with those from a parallel DNA metabarcoding analysis of soil from the same locations, and with pre-existing sequences in reference databases, before exploring the use of combined data sets as a basis for estimating total invertebrate biodiversity. We obtained 1,282 28S and 1,610 COI barcodes from a total of 1,947 invertebrate specimens, which were clustered into 247 (28S) and 366 (COI) OTUs, of which ≤ 10% were represented in GenBank. Coleoptera were most abundant (730 sequenced specimens), followed by Hymenoptera, Diptera, Lepidoptera, and Amphipoda. The most abundant OTU from both the 28S (153 sequences) and COI (140 sequences) data sets was an undescribed beetle from the family Salpingidae. Based on the occurrences of COI OTUs along the elevation gradient, we estimated there are ~1,000 arthropod species (excluding mites) on Hauturu, including 770 insects, of which 344 are beetles. A DNA metabarcoding analysis of soil DNA from the same sites resulted in the identification of similar numbers of OTUs in most invertebrate groups compared with the DNA barcoding, but less than 10% of the DNA barcoding COI OTUs were also detected by the metabarcoding analysis of soil DNA. A mark-recapture analysis based on the overlap between these data sets estimated the presence of approximately 6,800 arthropod species (excluding mites) on the island, including ~3,900 insects. Estimates of New Zealand-wide biodiversity for selected arthropod groups based on matching of the COI DNA barcodes with pre-existing reference sequences suggested over 13,200 insect species are present, including 4,000 Coleoptera, 2,200 Diptera, and 2,700 Hymenoptera species, and 1,000 arachnid species (excluding mites). These results confirm that metabarcoding analyses of soil DNA tends to recover different components of terrestrial invertebrate biodiversity compared to traditional invertebrate sampling, but the combined methods provide a novel basis for estimating invertebrate biodiversity.
Redundant Role of the Syk Protein Tyrosine Kinase in Mouse NK Cell Differentiation (1999)

Abstract Syk and ZAP-70 subserve nonredundant functions in B and T lymphopoiesis. In the absence of Syk, B cell development is blocked, while T cell development is arrested in the absence of ZAP-70. The receptors and the signaling molecules required for differentiation of NK cells are poorly characterized. Here we investigate the role of the Syk protein tyrosine kinase in NK cell differentiation. Hemopoietic chimeras were generated by reconstituting alymphoid (B−, T−, NK−) recombinase-activating gene-2 × common cytokine receptor γ-chain double-mutant mice with Syk−/− fetal liver cells. The phenotypically mature Syk−/− NK cells that developed in this context were fully competent in natural cytotoxicity and in calibrating functional inhibitory receptors for MHC molecules. Syk-deficient NK cells demonstrated reduced levels of Ab-dependent cellular cytotoxicity. Nevertheless, Syk−/− NK cells could signal through NK1.1 and 2B4 activating receptors and expressed ZAP-70 protein. We conclude that the Syk protein tyrosine kinase is not essential for murine NK cell development, and that compensatory signaling pathways (including those mediated through ZAP-70) may sustain most NK cell functions in the absence of Syk.
Evaluating Robustness of Counterfactual Explanations (2021)

Transparency is a fundamental requirement for decision making systems when these should be deployed in the real world. It is usually achieved by providing explanations of the system's behavior. A prominent and intuitive type of explanations are counterfactual explanations. Counterfactual explanations explain a behavior to the user by proposing actions-as changes to the input-that would cause a different (specified) behavior of the system. However, such explanation methods can be unstable with respect to small changes to the input-i.e. even a small change in the input can lead to huge or arbitrary changes in the output and of the explanation. This could be problematic for counterfactual explanations, as two similar individuals might get very different explanations. Even worse, if the recommended actions differ considerably in their complexity, one would consider such unstable (counterfactual) explanations as individually unfair. In this work, we formally and empirically study the robustness of counterfactual explanations in general, as well as under different models and different kinds of perturbations. Furthermore, we propose that plausible counterfactual explanations can be used instead of closest counterfactual explanations to improve the robustness and consequently the individual fairness of counterfactual explanations.
Variational Quantum Singular Value Decomposition (2021)

Singular value decomposition is central to many problems in engineering and scientific fields. Several quantum algorithms have been proposed to determine the singular values and their associated singular vectors of a given matrix. Although these algorithms are promising, the required quantum subroutines and resources are too costly on near-term quantum devices. In this work, we propose a variational quantum algorithm for singular value decomposition (VQSVD). By exploiting the variational principles for singular values and the Ky Fan Theorem, we design a novel loss function such that two quantum neural networks (or parameterized quantum circuits) could be trained to learn the singular vectors and output the corresponding singular values. Furthermore, we conduct numerical simulations of VQSVD for random matrices as well as its applications in image compression of handwritten digits. Finally, we discuss the applications of our algorithm in recommendation systems and polar decomposition. Our work explores new avenues for quantum information processing beyond the conventional protocols that only works for Hermitian data, and reveals the capability of matrix decomposition on near-term quantum devices.
Exploiting structure for intelligent Web search (2005)

Together with the rapidly growing amount of online data, we register an immense need for intelligent search engines that access a restricted amount of data as found in intranets or other limited domains. These sorts of search engine must go beyond simple keyword indexing/matching, but they also have to be easily adaptable to new domains without huge costs. The paper presents a mechanism that addresses both of these points: first of all, the internal document structure is being used to extract concepts which impose a directory-like structure on the documents, similar to those found in classified directories. Furthermore, this is done in an efficient way which is largely language independent and does not make assumptions about the document structure.
Interim Study of Procedures for Investigating the Effect of Light on Impression and Behavior (1973)

(1973). Interim Study of Procedures for Investigating the Effect of Light on Impression and Behavior. Journal of the Illuminating Engineering Society: Vol. 3, No. 1, pp. 87-94.
Cannabinoid Ester Constituents from High-PotencyCannabis sativa (2008)

Eleven new cannabinoid esters, together with three known cannabinoid acids and Delta9-tetrahydrocannabinol ( Delta9-THC ), were isolated from a high-potency variety of Cannabis sativa. The structures were determined by extensive spectroscopic analyses to be beta-fenchyl Delta9-tetrahydrocannabinolate ( 1), epi-bornyl Delta9-tetrahydrocannabinolate ( 2), alpha-terpenyl Delta9-tetrahydrocannabinolate ( 3), 4-terpenyl Delta 9-tetrahydrocannabinolate ( 4), alpha-cadinyl Delta9-tetrahydrocannabinolate ( 5), gamma-eudesmyl Delta9-tetrahydrocannabinolate ( 6), gamma-eudesmyl cannabigerolate ( 7), 4-terpenyl cannabinolate ( 8), bornyl Delta9-tetrahydrocannabinolate ( 9), alpha-fenchyl Delta9-tetrahydrocannabinolate ( 10), alpha-cadinyl cannabigerolate ( 11), Delta9-tetrahydrocannabinol ( Delta9-THC ), Delta9-tetrahydrocannabinolic acid A ( Delta9-THCA ), cannabinolic acid A ( CBNA), and cannabigerolic acid ( CBGA). Compound 8 showed moderate antimicrobial activity against Candida albicans ATCC 90028 with an IC 50 value of 8.5 microg/mL. The isolated acids and the ester-containing fractions showed low affinity to the CB-1 receptor. [corrected]
Magnetic Drug Targeting: A Novel Treatment for Intramedullary Spinal Cord Tumors (2018)

Most applications of nanotechnology in cancer have focused on systemic delivery of cytotoxic drugs. Systemic delivery relies on accumulation of nanoparticles in a target tissue through enhanced permeability of leaky vasculature and retention effect of poor lymphatic drainage to increase the therapeutic index. Systemic delivery is limited, however, by toxicity and difficulty crossing natural obstructions, like the blood spine barrier. Magnetic drug targeting (MDT) is a new technique to reach tumors of the central nervous system. Here, we describe a novel therapeutic approach for high-grade intramedullary spinal cord tumors using magnetic nanoparticles (MNP). Using biocompatible compounds to form a superparamagnetic carrier and magnetism as a physical stimulus, MNP-conjugated with doxorubicin were successfully localized to a xenografted tumor in a rat model. This study demonstrates proof-of-concept that MDT may provide a novel technique for effective, concentrated delivery of chemotherapeutic agents to intramedullary spinal cord tumors without the toxicity of systemic administration.
Chronic rapamycin treatment causes diabetes in male mice (2014)

Current evidence indicates that the mammalian target of rapamycin inhibitor rapamycin both increases longevity and, seemingly contradictorily, impairs glucose homeostasis. Most studies exploring the dimensions of this paradox have been based on rapamycin treatment in mice for up to 20 wk. We sought to better understand the metabolic effects of oral rapamycin over a substantially longer period of time in HET3 mice. We observed that treatment with rapamycin for 52 wk induced diabetes in male mice, characterized by hyperglycemia, significant urine glucose levels, and severe glucose and pyruvate intolerance. Glucose intolerance occurred in male mice by 4 wk on rapamycin and could be only partially reversed with cessation of rapamycin treatment. Female mice developed moderate glucose intolerance over 1 yr of rapamycin treatment, but not diabetes. The role of sex hormones in the differential development of diabetic symptoms in male and female mice was further explored. HET3 mice treated with rapamycin for 52 wk were gonadectomized and monitored over 10 wk. Castrated male mice remained glucose intolerant, while ovariectomized females developed significant glucose intolerance over the same time period. Subsequent replacement of 17β-estradiol (E2) in ovariectomized females promoted a recovery of glucose tolerance over a 4-wk period, suggesting the protective role of E2 against rapamycin-induced diabetes. These results indicate that 1) oral rapamycin treatment causes diabetes in male mice, 2) the diabetes is partially reversible with cessation of treatment, and 3) E2 plays a protective role against the development of rapamycin-induced diabetes.
Determination of bimodal molar mass distribution functions of polystyrene by photon correlation spectroscopy: numerical simulations and experimental realization in comparison with gel permeation chromatography data (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of bimodal molar mass distribution functions of polystyrene by photon correlation spectroscopy: numerical simulations and experimental realization in comparison with gel permeation chromatography dataGyula Vancso, Ivan Tomka, and Klara Vancso-PolacsekCite this: Macromolecules 1988, 21, 2, 415–420Publication Date (Print):February 1, 1988Publication History Published online1 May 2002Published inissue 1 February 1988https://pubs.acs.org/doi/10.1021/ma00180a022https://doi.org/10.1021/ma00180a022research-articleACS PublicationsRequest reuse permissionsArticle Views132Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts