gebhart/patrepeval huggingface dataset:
Abstract 1851: Safety of Aprotinin in CABG Patients: Results of the VA MultiCenter Prospective Randomized ROOBY Trial (2007)

Background and Hypothesis : Recently published evidence from an international registry ( JAMA 2007 ; 297 : 471 –479 ) associated the use of aprotinin during CABG with increased mortality (20.8%) compared with controls (12.7%) and recommended discontinuation of the clinical use of aprotinin as unsafe. Because evidence from registries is generally inferior compared to prospective multicenter randomized trials, we sought to determine if there was increased mortality with the use of aprotinin in a large, prospective randomized CABG trial in the United States. Based on a large body of available literature on the use of antifibrinolytic agents during CABG, we hypothesized that the use of aprotinin would not be associated with excessive mortality in the ROOBY Trial. Methods : The prospective randomized ROOBY Trial enrolled &gt;2,200 patients over five years at 18 VA cardiac surgery centers in the United States. A planned sub analysis was carried out on 1,750 CABG patients with one year follow up using collected data on the antifibrinolytic agent use. Results : Aprotinin was used during CABG (either on- or off-pump) by the majority of the centers participating in ROOBY (11/18=61%). One-year mortality for the aprotinin group was 3.2% and the mortality for the control group of patients receiving either no anti-bleeding agents or one of 2 lysine analog antifibrinolytics (aminocaproic acid or tranexamic acid) was 3.5% (p=.59). In addition, the rate of myocardial infarction at one year was similar in the 2 groups (aprotinin 3.2% vs 3.27% for the controls; p=NS). The rate of repeat revascularization at one year was slightly higher in the control group (4.05%) compared to the aprotinin group (2.6%). Conclusion : In the planned sub analysis of the prospective randomized ROOBY trial, no excessive mortality or morbidity was found to be associated with the use of aprotinin and the recommendation for discontinuation of clinical use of aprotinin in CABG appears unjustified. Adherence to the revised FDA indications for use of aprotinin during CABG should be emphasized.
Oxygen Consumption of the Aerobically-Perfused Cardioplegic Donor Heart at Different Temperatures (2018)

BACKGROUND The aim of this study was to investigate the oxygen consumption of explanted aerobically-perfused cardioplegic porcine hearts at different temperatures. MATERIAL AND METHODS Explanted hearts from 30 pigs weighing 50 kg were randomized into 5 groups. The hearts received continuous antegrade perfusion within a temperature-controlled sealed system. The perfusate consisted of an albumin-containing hyperoncotic cardioplegic nutrition solution with erythrocytes to a hematocrit of 10%. Five temperatures were studied: 37, 30, 22, 15, and 8°C. When the erythrocytes in the perfusate were fully saturated, the oxygenator was excluded from the circuit and blood gases were analyzed periodically until the erythrocytes had desaturated to less than 20%. Between 80% and 60% saturation the desaturation curves were linear in all groups and the oxygen consumption was calculated from this part of the curves. RESULTS The weight of the hearts was 208±4 g (mean ±SEM, n=30). The oxygen consumption in mL/min/100 g heart tissue was (mean ±SEM, n=6 in each group) 37°C: 1.10±0.04; 30°C: 0.58±0.02; 22°C: 0.33±0.01; 15°C: 0.21±0.01; and 8°C: 0.16±0.02. CONCLUSIONS The oxygen consumption of the cardioplegic perfused pig heart at normothermia was 1.1 mL/min/100 g and was reduced by 85% to 0.16 mL/min/100 g at 8°C.
Sotos syndrome (2007)

Sotos syndrome is an overgrowth condition characterized by cardinal features including excessive growth during childhood, macrocephaly, distinctive facial gestalt and various degrees of learning difficulty, and associated with variable minor features. The exact prevalence remains unknown but hundreds of cases have been reported. The diagnosis is usually suspected after birth because of excessive height and occipitofrontal circumference (OFC), advanced bone age, neonatal complications including hypotonia and feeding difficulties, and facial gestalt. Other inconstant clinical abnormalities include scoliosis, cardiac and genitourinary anomalies, seizures and brisk deep tendon reflexes. Variable delays in cognitive and motor development are also observed. The syndrome may also be associated with an increased risk of tumors. Mutations and deletions of the NSD1 gene (located at chromosome 5q35 and coding for a histone methyltransferase implicated in transcriptional regulation) are responsible for more than 75% of cases. FISH analysis, MLPA or multiplex quantitative PCR allow the detection of total/partial NSD1 deletions, and direct sequencing allows detection of NSD1 mutations. The large majority of NSD1 abnormalities occur de novo and there are very few familial cases. Although most cases are sporadic, several reports of autosomal dominant inheritance have been described. Germline mosaicism has never been reported and the recurrence risk for normal parents is very low (<1%). The main differential diagnoses are Weaver syndrome, Beckwith-Wiedeman syndrome, Fragile X syndrome, Simpson-Golabi-Behmel syndrome and 22qter deletion syndrome. Management is multidisciplinary. During the neonatal period, therapies are mostly symptomatic, including phototherapy in case of jaundice, treatment of the feeding difficulties and gastroesophageal reflux, and detection and treatment of hypoglycemia. General pediatric follow-up is important during the first years of life to allow detection and management of clinical complications such as scoliosis and febrile seizures. An adequate psychological and educational program with speech therapy and motor stimulation plays an important role in the global development of the patients. Final body height is difficult to predict but growth tends to normalize after puberty.
Synthesis and Characterization of Energetic 1,2‐Bis(Oxyamino)Ethane Salts (2006)

Abstract The synthesis, characterization, theoretical calculations, and safety studies of energetic salts based on 1,2‐bis(oxyamino)ethane, (H 2 NOCH 2 CH 2 ONH 2 ), were carried out. The salts were characterized by vibrational (infrared, Raman), multinuclear NMR studies ( 1 H, 13 C), differential scanning calorimetry (DSC), elemental analysis, and initial safety testing (impact and friction sensitivity). Single crystal X‐ray diffraction studies were carried out on the mono‐perchlorate and the double nitrate salts, revealing the expected structures.
Tumor and growth suppression of breast cancer cells by chromosome 17-associated functions. (1994)

Losses of functions from chromosome 17 are the most frequent genetic abnormalities in human breast cancer. To assess the biological role of chromosome 17 in the development of breast cancer, we transferred a normal human chromosome 17 to two breast cancer cell lines. No viable clone maintaining an intact chromosome was obtained in either MDA-MB-231 or MCF-7. Only one MDA-231/H17 clone contained the long arm of the transferred chromosome 17. Interestingly, this clone lost the ability to induce tumors in nude mice, indicating that at least one gene mapping to the long arm of chromosome 17 could suppress the tumorigenic phenotype. The p53 protein most likely was responsible for the selective loss of the short arm of the chromosome. Both cell lines have no wild-type p53 activity. MDA-MB-231 carries a single mutant TP53 allele, while MCF-7 carries two wild-type alleles, but p53 protein is excluded from the nucleus. Transfection in both cell lines of vectors expressing wild-type p53 produced only clones with rearrangements of the transfected TP53 complementary DNA. Thus, nonregulated expression of the p53 protein driven by the strong cytomegalovirus promoter may have triggered a rapid process of cell death. Stable expression of a mutant p53 in MCF-7 cells proved that nuclear localization of the protein was possible; however, no progression toward an estrogen-independent tumorigenic phenotype was induced. This work indicates that functional inactivation of the wild-type p53 protein and of the product of a gene located on 17q are essential to the development of breast neoplasms.
Silicon nanowires reliability and robustness investigation using AFM-based techniques (2013)

Silicon nanowires (SiNWs) have undergone intensive research for their application in novel integrated systems such as field effect transistor (FET) biosensors and mass sensing resonators profiting from large surface-to-volume ratios (nano dimensions). Such devices have been shown to have the potential for outstanding performances in terms of high sensitivity, selectivity through surface modification and unprecedented structural characteristics. This paper presents the results of mechanical characterization done for various types of suspended SiNWs arranged in a 3D array. The characterization has been performed using techniques based on atomic force microscopy (AFM). This investigation is a necessary prerequisite for the reliable and robust design of any biosensing system. This paper also describes the applied investigation methodology and reports measurement results aggregated during series of AFM-based tests.
Affect Regulation and the Repair of the Self (1994)

In 1994 Allan Schore published his groundbreaking book, Affect Regulation and the Origin of the Self, in which he integrated a large number of experimental and clinical studies from both the psychological and biological disciplines in order to construct an overarching model of social and emotional development. Since then he has expanded his regulation theory in more than two dozen articles and essays covering multiple disciplines, including neuroscience, psychiatry, psychoanalysis, developmental psychology, attachment, and trauma. Affect Regulation and the Repair of the Self contains chapters on neuropsychoanalysis and developmentally oriented psychotherapy. It is absolutely essential reading for all clinicians, researchers, and general readers interested in normal and abnormal human development.
STABILITY, NITROGEN MINERALIZATION CAPACITY AND AGRONOMIC VALUE OF COMPOST-BASED GROWING MEDIA FOR LETTUCE CULTIVATION (2012)

Seven composts were used as growing media for lettuce mixed with peat at 25 and 50% (v/v). On the unblended composts and the resulting 14 mixes were determined the main physical-chemical characteristics and the stability by means of a respirometric test in a liquid environment. The potential nitrogen (N)-mineralization capacity of the mixes was measured during the respirometric test solely by the ammonium (NH+ 4-N) determination. The lettuce pot-growing test was performed with and without fertilization; plant biomass and total Kjeldahl nitrogen (TKN) tissue content were measured after cultivation for two months. Compost origin, rate in substrates and fertilization affected plant growth and nitrogen uptake. Multiple regression analysis showed that the stability, proved to be a good predictor for plant growth inhibition. Moreover N-mineralization capacity showed a good fitting with plant uptake. The coupled stability and nitrogen mineralization test gives reliable information about the potential constraints in compost-based growing media.
ChemInform Abstract: THE CATALYTIC CHEMISTRY OF NITRIC OXIDE PART 2, REDUCTION OF NITRIC OXIDE OVER NOBLE METAL CATALYSTS (1974)

Abstract Die Reduktion von NO mit H 2 , CO und äquimolaren Hz/CO‐Gemischen an Pt.‐, Pd‐, Rh‐ und"Ru‐Trägerkatalysatoren wurde untersucht.
Highly Sensitive and Durable Sea-Urchin-Shaped Silver Nanoparticles Strain Sensors for Human-Activity Monitoring (2021)

High-performance strain sensors, composed of various artificial sensing materials on/in stretchable substrates, show great promise for applications in flexible electronic devices. Here, we demonstrated a highly sensitive and durable strain sensor consisting of a ribbon of close-packed sea-urchin-shaped silver nanoparticles (SUSNs) sandwiched between two layers of poly(dimethylsiloxane) (PDMS). Each of SUSNs possesses high-density and spherically distributed sharp spines over the body, which promotes electron transduction and further improves signal detection. This SUSN-based sensor possesses a desirable integration of high sensitivity (a gauge factor of 60) and large stretchability (up to 25%) at tensile sensing, broadening its application in wearable devices. Moreover, it also shows fast response (48 ms), good reproducibility, and long-term stability (>2500 cycles at 20% strain). It can also be used to detect compressing (sensitivity up to 31.5) and folding-type bending deformations. The sensing mechanism, the resistance of the sensors varying as the deformation load, results from the inter-spine contacts change and the microcracks evolution caused by variation in the gap between SUSNs. The sensor's sensitivity at different degrees of strain was also achieved by controlling the width of the close-packed SUSNs ribbon. For practical demonstration, the SUSN-based sensors could be used as wearable devices for monitoring human activities ranging from subtle deformations to substantial movements.
Bifurcations of Limit Cycles. Saddle Homoclinic Bifurcation (2015)

An important characteristic of the homoclinic orbit is the saddle quantity. Homoclinic trajectories (separatrix loops) may be formed not only by the separatrices of saddles on the plane, but also by the saddle separatrices of systems with a cylindrical phase space. In this case, generally speaking, two types of separatrix loops can be formed, namely, the librational loops, and the rotational ones, along which the angular variable accumulates and which encompass the cylinder.
Susceptibility of different strains of mice to hepatic infection with Plasmodium berghei (1994)

Despite the low susceptibility of BALB/c mice to hepatic infection by Plasmodium berghei, this animal model is routinely used to investigate the basic biology of the malaria parasite and to test vaccines and the immune response against exoerythrocytic (EE) stages derived from sporozoites. A murine model in which a large number of EE parasites are established would be useful for furthering such investigations. Therefore, we assayed six mouse strains for susceptibility to erythrocytic and hepatic infections. The administration of 50 sporozoites by intravenous inoculation was sufficient to establish erythrocytic infections in five of five C57BL/6 mice compared with 10,000 sporozoites required to infect 100% of BALB/c mice. To assay for hepatic infections, mice received an intravenous inoculum of 10(6) sporozoites, and liver sections for light microscopy and histology were obtained at 29 and 44 h postinoculation. EE parasites were visualized by immunofluorescence, using an antibody to a P. falciparum heat shock protein. The mean number of EE parasites per 100 cm2 for C57BL/6 and A/J strains was significantly higher than that for BALB/c (2,190 +/- 260, 88 +/- 38, and 6 +/- 2, respectively). The proportion of inoculated sporozoites transforming into liver schizonts was 8.2% in C57BL/6 and < 1% in C3H/HeJ, DBA/1, and Swiss CD-1/ICR mice. Nonspecific inflammatory infiltrates around EE parasites were less prevalent in liver sections from C57BL/6 mice than in those from BALB/c mice, which contributed to the decrease in developing EE stages in BALB/c mice. These data indicate that the C57BL/6-P. berghei system is preferable for investigating the biology and immunology of liver stage parasites.
Expression of human mucin genes in normal kidney and renal cell carcinoma (2002)

This study is the first large series investigating human mucin gene expression in the kidney. MUC1, MUC3 and MUC6 are expressed in normal and tumour kidney. The over-expression of MUC3 in renal cell carcinomas favours its implication in renal tumorigenesis.
Molecular Catalysis of Electrochemical Reactions: Competition between Reduction of the Substrate and Deactivation of the Catalyst by a Cosubstrate Application to N2O Reduction (2021)

Abstract In the context of molecular catalysis of electrochemical reactions, the competition between reduction of the substrate and deactivation of the catalyst by a cosubstrate is investigated. It is a frequent situation because proton donors are ubiquitous cosubstrates in reductive electrochemical reactions and molecular catalysts, either transition metal complexes or organic aromatic molecules, and are often prone to electrohydrogenation. We provide a formal kinetic analysis in the framework of cyclic voltammetry, and we show that the response is governed by two parameters and that the competition does not depend on the scan rate. From this analysis a methodology is proposed to analyze such systems and then illustrated via the study of N 2 O to N 2 electroreduction catalyzed by 4‐cyanopyridine in acetonitrile electrolyte with water as proton donor. Incidentally, new insights into the mechanism of 4‐cyanopyridine radical anion protonation are revealed.
Horizontal Axis Tidal Current Turbine: Numerical and Experimental Investigations (2014)

Marine current energy is one of the most interesting renewable and clean energy resources that have been less exploited respect to wind energy. Only in Europe this type of energy is available for 75 millions of KiloWatts and in terms of exploitable energy the amount is about 50 milliards of KiloWattHour. In the last years, the realization of horizontal axis turbine for the exploitation of the tidal currents is having, to world-wide level, a considerable increment. Many are the societies and the consortia that have decided to invest in such type of energetic source. The present paper provides a summary of the work done at the Department of Aeronautical Engineering (DPA) of the University of Naples “Federico II ” regarding the numerical and experimental investigations of a scaled model of an horizontal axis hydro turbines designed to harness energy from marine tidal currents. The horizontal axis hydro turbine has been designed and analyzed using numerical codes available at DPA. Among these codes, some were already available at DPA and were based on standard Glauert’s blade element theory, modified following Prandtl’s theory and the “Higher Order Correction ” method, while a new unsteady code, based on vortex lifting line theory, has been developed and now is under validation. The wind turbine has been designed to work at a specific Tip Speed Ratio (TSR) and particular effort has been put in order to avoid the cavitation on the blade surface.
An Iterative Approach for Identifying Complaint Based Tweets in Social\n Media Platforms (2020)

Twitter is a social media platform where users express opinions over a\nvariety of issues. Posts offering grievances or complaints can be utilized by\nprivate/ public organizations to improve their service and promptly gauge a\nlow-cost assessment. In this paper, we propose an iterative methodology which\naims to identify complaint based posts pertaining to the transport domain. We\nperform comprehensive evaluations along with releasing a novel dataset for the\nresearch purposes.\n
Field Studies Using a Recombinant Mycoinsecticide ( Metarhizium anisopliae ) Reveal that It Is Rhizosphere Competent (2002)

In the summer of 2000, we released genetically altered insect-pathogenic fungi onto a plot of cabbages at a field site on the Upper Marlboro Research Station, Md. The transformed derivatives of Metarhizium anisopliae ARSEF 1080, designated GPMa and GMa, carried the Aequorea victoria green fluorescent protein (gfp) gene alone (GMa) or with additional protease genes (Pr1) (GPMa). The study (i) confirmed the utility of gfp for monitoring pathogen strains in field populations over time, (ii) demonstrated little dissemination of transgenic strains and produced no evidence of transmission by nontarget insects, (iii) found that recombinant fungi were genetically stable over 1 year under field conditions, and (iv) determined that deployment of the transgenic strains did not depress the culturable indigenous fungal microflora. The major point of the study was to monitor the fate (survivorship) of transformants under field conditions. In nonrhizosphere soil, the amount of GMa decreased from 10(5) propagules/g at depths of 0 to 2 cm to 10(3) propagules/g after several months. However, the densities of GMa remained at 10(5) propagules/g in the inner rhizosphere, demonstrating that rhizospheric soils are a potential reservoir for M. anisopliae. These results place a sharp focus on the biology of the soil/root interphase as a site where plants, insects, and pathogens interact to determine fungal biocontrol efficacy, cycling, and survival. However, the rhizospheric effect was less marked for GPMa, and overall it showed reduced persistence in soils than did GMa.
Automatic Medical Image Diagnosis: Highlights from the 2021 IEEE 5-Minute Video Clip Contest [SP Competitions] (2022)

The annual IEEE 5-Minute Video Clip Contest (5-MICC) was launched in 2020 by the IEEE Signal Processing Society (SPS), and the selected topic for the competition at IEEE ICIP 2021 was “Automatic Medical Image Diagnosis.” The organizing committee selected three finalist videos and placed them online for public voting. The first one addresses a deep learning system that targets enhancement and disease diagnostic in otoscopy images, the second concerns the use of neural networks for cancer detection in tissue scans, and the third deals with a deep learning tool for automatic COVID-19 diagnosis. Taking the public voting results from more than 1,300 participants into consideration, the panel of judges decided the final rankings of the three videos. This article presents an overview of this virtual edition of the 5-MICC at ICIP 2021, describing the competition setup, the teams, and their approaches.
Efficient Method for the Preparation ofEscherichia coliPolynucleotide Phosphorylase Suitable for the Synthesis of Polynucleotides (1993)

Journal Article Efficient Method for the Preparation of Escherichia coli Polynucleotide Phosphorylase Suitable for the Synthesis of Polynucleotides Get access Go Marumo, Go Marumo Research Laboratories, Yamasa Corporation, Choshi, Chiba 288, Japan Search for other works by this author on: Oxford Academic Google Scholar Toshitada Noguchi, Toshitada Noguchi Research Laboratories, Yamasa Corporation, Choshi, Chiba 288, Japan Search for other works by this author on: Oxford Academic Google Scholar Yuichiro Midorikawa Yuichiro Midorikawa Research Laboratories, Yamasa Corporation, Choshi, Chiba 288, Japan Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 57, Issue 3, 1 January 1993, Pages 513–514, https://doi.org/10.1271/bbb.57.513 Published: 01 January 1993 Article history Received: 20 October 1992 Published: 01 January 1993
Response of Various Metals to Large Torsional Strains Over a Large Range of Strain Rates—Part 1: Ductile Metals (1983)

This paper presents torsional test results for six ductile metals subjected to large shear strains and high strain rates. Included are OFHC copper, Cartridge brass, Nickel 200, Armco IF iron, Carpenter electrical iron, and 1006 steel. Torsional shear strains as high as 700 percent are achieved and strain rates vary from quasi-static to over 300 s−1. At the lower strain rates all of the materials exhibit positive strain hardening and strain rate hardening under essentially isothermal conditions. At the higher strain rates there is significant adiabatic thermal softening and strong evidence for shear instabilities and localizations. Constitutive relationships are derived from the test data and finite element computations of the tests are performed.