gebhart/patrepeval huggingface dataset:
Differential Regulation of Interleukin-10 (IL-10) and IL-12 by Glucocorticoids In Vitro (1998)

Antigen-presenting cells are thought to modulate the development of Th1 and Th2 cells by the secretion of interleukin-10 (IL-10) and IL-12. Because glucocorticoids (GC) favor the development of Th2 responses, we determined whether dexamethasone (DEX) and hydrocortisone (HC) have differential effects on lipopolysaccharide-induced IL-10 and IL-12 production in whole-blood cultures. Significant inhibition of IL-12(p40) and IL-12(p70) was found with 10(-8) mol/L and 10(-9) mol/L DEX respectively, whereas IL-10 was relatively insensitive or even stimulated. Accordingly, the expression of IL-12(p40) and IL-12(p35) mRNA was more sensitive to DEX than IL-10 mRNA. The glucocorticoid receptor (GR) antagonist RU486 enhanced IL-12 production and largely abrogated the inhibition of IL-12 by GC, indicating that this suppression was mainly GR-mediated. High concentrations of RU486 were inhibitory for IL-10, suggesting that GC may exert a positive effect on IL-10. In the presence of neutralizing anti-IL-10 antibodies, DEX was still capable of IL-12 suppression whereas RU486 still enhanced IL-12 production, indicating that GC do not modulate IL-12 via IL-10 exclusively. Taken together these results indicate that GC may favor Th2 development by differential regulation of IL-10 and IL-12.
Via-configurable routing architectures and fast design mappability estimation for regular fabrics (2005)

In this paper, we describe a new via-configurable routing architecture which shows much better throughput and performance than the previous structures. We demonstrate how to construct a single-via-mask fabric to reduce further the mask cost, and we analyze the penalties which it incurs. To solve the routability problem commonly existing in fabric-based designs, an efficient white-space allocation scheme is suggested, which provides a fast design convergence and early prediction of the circuit mappability to a given fabric.
Proposal for a simple polarization converter based on integrated optical ion exchanged waveguide (2010)

A simple, compact, low-cost electro-optic polarization converter based on a nematic liquid crystal (LC) sandwiched between two ion-exchanged glass channel waveguides is proposed. A three-dimensional (3D) fully-vectorial (FV) finite difference beam propagation method (FDBPM) is used to simulate this optical device. The performance of the proposed polarization converter is analyzed numerically at zero and 5 V applied voltage for the case of strong anchoring of LC molecules to the surface of the waveguide. The polarization conversion efficiency is ~65% at a wavelength of 1550 nm. The total length of the directional coupler structure based converter is only 724 µm.
Data from Crizotinib-Resistant <i>ROS1</i> Mutations Reveal a Predictive Kinase Inhibitor Sensitivity Model for <i>ROS1</i>- and <i>ALK</i>-Rearranged Lung Cancers (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; The identification of molecular mechanisms conferring resistance to tyrosine kinase inhibitor (TKI) is a key step to improve therapeutic results for patients with oncogene addiction. Several alterations leading to EGFR and anaplastic lymphoma kinase (ALK) resistance to TKI therapy have been described in non–small cell lung cancer (NSCLC). Only two mutations in the ROS1 kinase domain responsible for crizotinib resistance have been described in patients thus far.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; A patient suffering from a metastatic NSCLC harboring an &lt;i&gt;ezrin&lt;/i&gt; (&lt;i&gt;EZR&lt;/i&gt;)&lt;i&gt;–ROS1&lt;/i&gt; fusion gene developed acquired resistance to the ALK/ROS1 inhibitor crizotinib. Molecular analysis (whole-exome sequencing, CGH) and functional studies were undertaken to elucidate the mechanism of resistance. Based on this case, we took advantage of the structural homology of ROS1 and ALK to build a predictive model for drug sensitivity regarding future ROS1 mutations.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Sequencing revealed a dual mutation, S1986Y and S1986F, in the ROS1 kinase domain. Functional &lt;i&gt;in vitro&lt;/i&gt; studies demonstrated that ROS1 harboring either the S1986Y or the S1986F mutation, while conferring resistance to crizotinib and ceritinib, was inhibited by lorlatinib (PF-06463922). The patient's clinical response confirmed the potency of lorlatinib against S1986Y/F mutations. The ROS1 S1986Y/F and ALK C1156Y mutations are homologous and displayed similar sensitivity patterns to ALK/ROS1 TKIs. We extended this analogy to build a model predicting TKI efficacy against potential ROS1 mutations.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Clinical evidence, &lt;i&gt;in vitro&lt;/i&gt; validation, and homology-based prediction provide guidance for treatment decision making for patients with &lt;i&gt;ROS1&lt;/i&gt;-rearranged NSCLC who progressed on crizotinib. &lt;i&gt;Clin Cancer Res; 22(24); 5983–91. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Intracerebral Implantation of Hydrogel‐Coupled Adhesion Peptides: Tissue Reaction (1995)

Arg-Gly-Asp peptides (RGD) were synthesized and chemically coupled to the bulk of N-(2-hydroxypropyl) methacrylamide-based polymer hydrogels. Fourier Transform Infrared Spectroscopy (FTIR) and amino acid analysis confirmed the peptide coupling to the polymer. Activated and control (unmodified) polymer matrices were stereotaxically implanted in the striata of rat brains, and two months later the brains were processed for immunohistochemistry using antibodies for glial acidic fibrillary protein (GFAP), laminin and neurofilaments. RGD-containing polymer matrices promoted stronger adhesion to the host tissue than the unmodified polymer matrices. In addition, the RGD-grafted polymer implants promoted and supported the growth and spread of GFAP-positive glial tissue onto and into the hydrogels. Neurofilament-positive fibers were also seen running along the surface of the polymer and, in some instances, penetrating the matrix. These findings are discussed in the context of using bioactive polymers as a new approach for promoting tissue repair and axonal regeneration of damaged structures of the central nervous system.
The safety and outcome of joint replacement surgery in liver transplant recipients (2003)

A small group of patients may require total hip arthroplasty, total knee arthroplasty, or other joint replacement surgery after OLT for osteoporotic fractures, osteonecrosis, and osteoarthritis. Although arthroplasty is safe in the general population, its safety in liver transplant recipients is unclear. The aim of the study was to determine the safety and outcome of joint replacement surgery in our liver transplant recipients. A retrospective analysis was performed on all liver transplant recipients who had total joint arthroplasty at a single teaching institution between 1986 and 2002. Data regarding major intraoperative and postoperative complications was obtained from the medical charts and a hospital-based computer system. Of over 1,200 liver transplant recipients, we identified 7 patients who underwent 12 total arthroplasties (8 knee, 3 hip, 1 ankle). Joint replacements were performed electively for osteonecrosis (5 of 12) and osteoarthritis (5 of 12), whereas two hip arthroplasties were performed emergently for fractures. All patients with osteonecrosis or hip fracture had been treated with prolonged corticosteroids. There were no deaths or major complications in the intraoperative and postoperative periods. On long-term follow-up, no patients have had pain, dislocation, or infection in the postsurgical joint. No joint revision surgery has been required. In conclusion, a small number of stable liver transplant recipients at our institution underwent joint replacement surgery without major short-term or long-term complications. Our study suggests that joint replacement surgery may be safely and successfully performed in this population, although larger, randomized, prospective trials are needed to confirm our findings.
Dual Peroxisome Proliferator–Activated Receptor α/δ Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects (2013)

The dual PPARα/δ agonist GFT505 is a liver-targeted insulin-sensitizer that is a promising drug candidate for the treatment of type 2 diabetes and nonalcoholic fatty liver disease.
Thiazolopyrimidines (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThiazolopyrimidinesScott J. Childress and R. L. McKeeCite this: J. Am. Chem. Soc. 1951, 73, 8, 3862–3864Publication Date (Print):August 1, 1951Publication History Published online1 May 2002Published inissue 1 August 1951https://pubs.acs.org/doi/10.1021/ja01152a090https://doi.org/10.1021/ja01152a090research-articleACS PublicationsRequest reuse permissionsArticle Views592Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pulse width modulated push-pull driven parallel resonant converter with active free-wheel (2023)

An apparatus and method for high frequency alternating power generation to control kilowatts of supplied power in microseconds. The present invention includes a means for energy storage, push-pull switching means, control electronics, transformer means, resonant circuitry and means for excess energy recovery, all in electrical communication. A push-pull circuit works synchronously with a force commutated free-wheel transistor to provide current pulses to a transformer. A change in the conduction angle of the push-pull circuit changes the amount of energy coupled into the transformer's secondary oscillating circuit, thereby altering the induced secondary resonating voltage. At the end of each pulse, the force commutated free-wheel transistor causes residual excess energy in the primary circuit to be transmitted back to the storage capacitor for later use.
The evidence base for aural rehabilitation with the bone-anchored hearing aid (2002)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Quantitative Nanoproteomics for Protein Complexes (QNanoPX) Related to Estrogen Transcriptional Action (2009)

We developed an integrated proteomics approach using a chemically functionalized gold nanoparticle (AuNP) as a novel probe for affinity purification to analyze a large protein complex in vivo. We then applied this approach to globally map the transcriptional activation complex of the estrogen response element (ERE). This approach was designated as quantitative nanoproteomics for protein complexes (QNanoPX). In this approach, the positive AuNP-ERE probes were functionalized with polyethylene glycol (PEG), and the consensus sequence of ERE and negative AuNP-PEG probes were functionalized with PEG without the ERE via a thiolated self-assembly monolayer technique. The AuNP-ERE probe had substantially low nonspecific binding and high solubility, which resulted in a 20-fold enrichment of the factor compared with gel beads. In addition, the surface-only binding allows the probe to capture a large protein complex without any restrictions due to pore size. The affinity purification method was combined with MS-based quantitative proteomics and statistical methods to reveal the components of the ERE complex in MCF-7 cells and to identify those components within the complex that were altered by the presence of 17beta-estradiol (E2). Results indicated that a majority of proteins pulled down by the positive probe exhibited significant binding, and approximately one-half of the proteins, including estrogen receptor alpha (ERalpha), were slightly but significantly affected by a 24-h treatment with E2. Based on a combination of bioinformatics and pathway analysis, most of the affected proteins, however, appeared to be related to the transcriptional regulation of not only ERalpha but also c-Myc. Further confirmation indicated that E2 enhanced the ERE binding of c-Myc by 14-fold, indicating that c-Myc may play a major role, along with ERalpha, in E2-mediated transcription. Taken together, our results demonstrated a successful QNanoPX approach toward new pathway discovery and further revealed the importance of cross-interactions among transcription factors.
Antimicrobial Effects of Nisin, Essential Oil, and γ‐Irradiation Treatments against High Load of Salmonella typhimurium on Mini‐carrots (2015)

This study shows the effect of using γ irradiation at low dose (1 kGy) to reduce significantly the growth of Salmonella typhimurium in mini-carrots. It also shows that combination of nisin, essential oils with γ irradiation have the best antibacterial effects against S. Typhimurium during the storage of mini-carrots. The results can be used for practical application in food industry in terms of food safety.
Application of Dope-free Tubular Connection to SAGD and its Works (1999)

Abstract This study deals with the laboratory test results on the application of a dope-free connection (DFC) to a steam injection well, and the running results in the actual well. A mechanical shock test, thermal shock test, and make-and-break (M&amp;B) test were performed to evaluate the durability and the galling resistance of DFC with the new surface treatment. In addition, the effect of coating damage on the connection performance has been investigated. Under the predicted loading conditions, the connection performance was evaluated. The connections were used in steam assisted gravity drains (SAGD). As the results of the test, it was found that DFC have enough galling resistance at an extremely low temperature and after a thermal shock was applied thereto. The galling resistance was not degraded in the case of a connection having a solid lubricant with coating damage. The joint strength and the gas tightness were maintained under repeated tensile and compressive loads at an elevated temperature. In the field usage, all connections were made-up without any thread compound grease (TCG), so that their running efficiency could be improved. In conclusion, it is apparent from the results of the tests that DFC can endure field application. DFC not only eliminates the environmental problems caused by TCG, but also has some potential for saving running time.
Effects of Pollen Extract in Association with Vitamins (Deprox 500®) for Pain Relief in Patients Affected by Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Results from a Pilot Study (2013)

The pollen extract associated with vitamins (DEPROX 500®) significantly improved total symptoms, pain, and QoL in patients with non-inflammatory CP/CPPS without severe side effects.
Synthesis of long-chain polyols from the Claisen condensation of γ-valerolactone (2019)

Synthesis of C10–C21 branched polyols from the Claisen condensation of GVL.
Zirconium Complexes Supported by an N-Perfluoro-Arylated Diamidopyridyl Ligand: Synthesis of Hydrazinediido Complexes (2013)

The N-perfluoro-phenylated pyridyldiamine H2N2(PFP)N(py) (1) has been prepared by a palladium-catalyzed coupling of hexafluorobenzene and the diamine (H2NCH2)2C(CH3)(2-C5H4N) using the palladacycle trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]palladium(II) as catalyst. Reactions of H2N2(PFP)N(py) and Zr(NMe2)4 at room temperature or 90 °C led to the complexes [(N(PFP)N2(TFAP)N(py))ZrF(NMe2)] (2) and [(N2(TFAP)N(py))ZrF2] (3) in which one or two dimethylamido groups replaced one or two ortho fluorine atoms of the pentafluorophenyl groups in the ligand. Reaction of Me3SiX (X = Cl, I) with [(N2(TFAP)N(py))ZrF2] (3) resulted in the formation of mixed halogenated complexes [(N2(TFAP)N(py))ZrFI] (4) and [(N2(TFAP)N(py))ZrFCl] (5) in which the axially bound fluorido ligand is substituted. Reaction of [(N2(TFAP)N(py))ZrF2] (3) with LiNHNPh2 afforded the monohydrazido(1-) complex [(N2(TFAP)N(py))ZrF(NHNPh2)] (6) which was converted to the dimeric fluoro-potassium bridged hydrazinediido complex [Zr(N2(TFAP)N(py))FNNPh2K]2 (7) using KHMDS. The corresponding reaction with LiHMDS yielded the monomeric, donor free complex [Zr(N2(TFAP)N(py))NNPh2] (8).
Interpersonal meaning (2018)

Abstract This introduction comprises four main sections. Section 1 introduces the overall theoretical architecture of Systemic Functional Linguistics (hereafter SFL) by way of contextualising the focus on interpersonal grammar in this special issue. Section 2 looks in more detail at the interpersonal discourse semantics underlying this work, briefly introducing the systems of negotiation and appraisal realised through interpersonal grammar. Section 3 turns to the concept of grammatical metaphor, a concept which bears critically on the realisation relationship between interpersonal discourse semantics and lexicogrammar in SFL. Section 4 comments on the challenge of intradisciplinary dialogue.
On Training Targets and Objective Functions for Deep-learning-based Audio-visual Speech Enhancement (2019)

Audio-visual speech enhancement (AV-SE) is the task of improving speech quality and intelligibility in a noisy environment using audio and visual information from a talker. Recently, deep learning techniques have been adopted to solve the AV-SE task in a supervised manner. In this context, the choice of the target, i.e. the quantity to be estimated, and the objective function, which quantifies the quality of this estimate, to be used for training is critical for the performance. This work is the first that presents an experimental study of a range of different targets and objective functions used to train a deep-learning-based AV-SE system. The results show that the approaches that directly estimate a mask perform the best overall in terms of estimated speech quality and intelligibility, although the model that directly estimates the log magnitude spectrum performs as good in terms of estimated speech quality.
Dequantization bias for JPEG decompression (2002)

Standard JPEG decompression reconstructs quantized DCT coefficients to the center for the quantization bin. This fails to exploit the nonuniform distribution of the AC coefficients. Assuming a Laplacian distribution, we derive a maximum likelihood estimate of the Laplacian parameter, based on the quantized coefficients available at the decoder, and use this estimate to optimally bias the reconstruction levels during decompression. As a decoder enhancement, this technique is fully compatible with the JPEG standard and does not modify the JPEG compressed bit stream. Extensive simulations indicate that, at typical compression ratios, biased reconstruction results in modest PSNR improvements-about 0.25 dB or higher-and slight subjective improvements, for little or no computational cost. Furthermore, simulations show that the PSNR improvements are very close (within 0.07 dB) to the best theoretically possible.
Members of the microRNA cluster 17-92 are disease specifically regulated in fibroblasts of idiopathic pulmonary fibrosis (2019)

MicroRNA cluster 17-92 is involved in cell proliferation and tissue remodeling in tumors as well as in chronic inflammatory lung diseases, such as asthma. The regulation of microRNA cluster 17-92 is not well studied. So far, it was only reported in tumor cells C/EBP-b was shown to down-regulate the expression of microRNA cluster 17-92. <b>Methods:</b> the expression and regulation of microRNA cluster 17-92 was assessed by quantitative PCR in primary fibroblast cells isolated of nine patients with IPF. Isolated cells showed characteristics of myo-fiboblasts, airway smooth muscle cells were used as control. The regulation of the microRNA cluster was investigated by stimulating the fibroblasts with platelet derived growth factor-BB (PDGF-BB), folic acid (FA), or Bisphenol A (BisA). DNA mobility shift assay (EMSA) and Western-blotting were used to identify the C/EBP-isoforms present in nuclear protein extracts before and after stimulation. <b>Results:</b> In contrast to non-IPF fibroblasts all guide strand miRs of the microRNA cluster 17-92 were upregulated in IPF cells. In control cells, PDGF-BB downregulated only specifc miR-19a-3 and 19b-3p, while it did not modify its expression in IPF cells. PDGF-BB upregulated the expression of C/EBP-b in all fibroblasts. C/EBP-a was present, but its expression was not modified by PDGF-BB. EMSA showed that C/EBP-b, but not C/EBP-a was binding to the corresponding C/EBP binding DNA sequence but difference between IPF and non-IPF fibroblasts were not detected. <b>Conclusion:</b> In IPF, the expression and regulation of microRNA cluster 17-92 is disease and stimulus specifically regulated, which may be controlled by C/EBP-β.
One-Month Prophylactic Use of OKT3 in Cadaver Kidney Transplant Recipients (1989)

No AccessJournal of Urology1 Mar 1989One-Month Prophylactic Use of OKT3 in Cadaver Kidney Transplant Recipients A. Debure, N. Chkoff, L. Chatenoud, M. Lacombe, H. Campos, L.H. Noël, G. Goldstein, J.F. Bach, and H. Kreis A. DebureA. Debure More articles by this author , N. ChkoffN. Chkoff More articles by this author , L. ChatenoudL. Chatenoud More articles by this author , M. LacombeM. Lacombe More articles by this author , H. CamposH. Campos More articles by this author , L.H. NoëlL.H. Noël More articles by this author , G. GoldsteinG. Goldstein More articles by this author , J.F. BachJ.F. Bach More articles by this author , and H. KreisH. Kreis More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)40960-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "One-Month Prophylactic Use of OKT3 in Cadaver Kidney Transplant Recipients." The Journal of Urology, 141(3 Part 1), p. 685 © 1989 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 141Issue 3 Part 1March 1989Page: 685 Advertisement Copyright & Permissions© 1989 by The American Urological Association Education and Research, Inc.MetricsAuthor Information A. Debure More articles by this author N. Chkoff More articles by this author L. Chatenoud More articles by this author M. Lacombe More articles by this author H. Campos More articles by this author L.H. Noël More articles by this author G. Goldstein More articles by this author J.F. Bach More articles by this author H. Kreis More articles by this author Expand All Advertisement Loading ...
Data mining for hypertext (tutorial session) (title only) (2000)

No abstract available.