gebhart/patrepeval huggingface dataset:
Early Weightbearing After Operatively Treated Trimalleolar Ankle Fractures with Large Posterior Malleolar Fragments (2018)

Category: Trauma Introduction/Purpose: No consensus exists regarding postoperative rehabilitation protocols after surgical fixation of unstable trimalleolar ankle fractures with large posterior malleolar fragments. Additionally, no consensus exists regarding type of fixation of large posterior malleolar fragments in these fractures. It is unclear whether clinical results with early weightbearing differ between large posterior malleolar fragments fixed with either screws alone or a plate and screws construct. We evaluated fracture displacement with simulated early weightbearing in a cadaveric model. Methods: Sixteen fresh-frozen lower extremities were assigned to Group 1, trimalleolar ankle fracture with a large posterior malleolar fragment fixed with screws (n=8) or Group 2, trimalleolar ankle fracture with a large posterior malleolar fragment fixed with a plate and screws construct (n=8). Both Groups were tested with an axial compressive load at 3.2 Hz from 100 to 1,000 N and internal/external torque at 1.6 Hz at 0.5 Nm for 250,000 cycles to simulate 5 weeks of full weightbearing. Displacement was measured by differential variable reluctance transducer. Results: The average motion at all fracture sites in both groups was less than 1 mm. Group 1 displacement of the medial, lateral, and posterior malleolar fracture was 0.30 ± 0.27 mm, 0.12 ± 0.11 mm, and 0.87 ± 0.68 mm respectively. Group 2 displacement of the medial, lateral, and posterior malleolar fracture was 0.78 ± 1.52 mm, 0.12 ± 0.16 mm, and 0.87 ± 1.20 mm respectively. There was no significant difference between the average motion at all fractures sites between Group 1 and Group 2 (P &gt; 0.05). There was no statistical correlation between fracture displacement and bone mineral density. Conclusion: This study supports early weightbearing after surgical fixation of unstable trimalleolar ankle fractures regardless of type of fixation of the posterior malleolus. Further investigation of early weightbearing protocols after surgical fixation of unstable trimalleolar ankle fractures are needed to help guide future treatment.
Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice (2003)

Cholesterol 7alpha-hydroxylase, a rate-limiting enzyme for bile acid synthesis, has been implicated in genetic susceptibility to atherosclerosis. The gene, CYP7A1, encoding a protein with this activity, is expressed normally only in hepatocytes and is highly regulated. Our cyp7A1 gene knockout mouse colony, as young adults on a chow diet, is hypercholesterolemic. These mice were characterized extensively to understand how cyp7A1 affects lipid and bile acid homeostasis in different tissue compartments and whether gender plays a modifying role. Both male and female cyp7A1-deficient mice had decreased hepatic LDL receptors, unchanged hepatic cholesterol synthesis, increased intestinal cholesterol synthesis and bile acid transporters, and decreased fecal bile acids but increased fecal sterols. In females, cyp7A1 deficiency also caused changes in hepatic fatty acid metabolism, decreased hepatic canalicular bile acid transporter, Bsep, and gallbladder bile composition altered to a lithogenic profile. Taken together, the data suggest that cyp7A1 deficiency results in a proatherogenic phenotype in both genders and leads to a prolithogenic phenotype in females.
Sizes and Shapes of Perivascular Spaces Surrounding Murine Pial Arteries (2023)

<b>Background:</b> Flow of cerebrospinal fluid (CSF) through brain perivascular spaces (PVSs) is essential for the clearance of interstitial metabolic waste products whose accumulation and aggregation is a key mechanism of pathogenesis in many diseases. The PVS geometry has important implications for CSF flow as it affects CSF and solute transport rates. Thus, the size and shape of the perivascular spaces are essential parameters for models of CSF transport in the brain and require accurate quantification. <b>Methods:</b> We segmented two-photon images of pial (surface) PVSs and the adjacent arteries and characterized their sizes and shapes of thousands of cross sections from 14 PVS segments in 9 mice. Based on the analysis, we propose an idealized model that approximates the cross-sectional size and shape of pial PVSs, closely matching their area ratios and hydraulic resistances. <b>Results:</b> PVS size only approximately scales with vessel size, and the ratio of PVS-to-vessel area varies widely across the thousands of cross sections analyzed. The hydraulic resistance per unit length of the PVS scales with the PVS cross-sectional area, and we found a power-law fit that predicts resistance as a function of the area. Three idealized geometric models were compared to PVSs imaged in vivo, and their accuracy in reproducing hydraulic resistances and PVS-to-vessel area ratios were evaluated. The area ratio was obtained across thousands of different cross sections, and we found that the distribution peaks for the original PVS and its closest idealized fit (polynomial fit) were 1.12 and 1.21, respectively. The peak of the hydraulic resistance distribution is 1.73 x 10 <sup>15</sup> Pa-s/m <sup>5</sup> and 1.44 x 10 <sup>15</sup> Pa-s/m <sup>5</sup> for the segmentation and its closest idealized fit, respectively. <b>Conclusions:</b> Brief summary and potential implicationsPVS hydraulic resistance can be reasonably predicted as a function of the PVS area. The proposed polynomial-based fit most closely captures the shape of the PVS with respect to area ratio and hydraulic resistance. Idealized PVS shapes are convenient for modeling, which can be used to better understand how anatomical variations affect clearance and drug delivery transport.
Modelling Knowledge Production and Integration in Working Environments (2011)

This chapter introduces a formal model of a complex knowledge integration process named ‘thinking along’. Here the firm is modelled as a working environment consisting of agents arranged into work-practices, which provide the context for their interactions. The objective of the simulations reported here is to compare two different practice structures and test their effectiveness for solving problems by thinking along. To do so we will also introduce the notion of problem complexity as the basis for different experiments. From such comparison it emerged that complex problems are better tackled when practices group together agents with disparate skills (i.e. divisional practices) whereas simple problems can be more effectively addressed by organisational practices composed of agents with similar skills (i.e. functional practices). In either case, the simulated knowledge integration process played the dominant role.Request access from your librarian to read this chapter's full text.
Learning Monocular Dense Depth from Events (2020)

Event cameras are novel sensors that output brightness changes in the form of a stream of asynchronous ”events” instead of intensity frames. Compared to conventional image sensors, they offer significant advantages: high temporal resolution, high dynamic range, no motion blur, and much lower bandwidth. Recently, learning-based approaches have been applied to event-based data, thus unlocking their potential and making significant progress in a variety of tasks, such as monocular depth prediction. Most existing approaches use standard feed-forward architectures to generate network predictions, which do not leverage the temporal consistency presents in the event stream. We propose a recurrent architecture to solve this task and show significant improvement over standard feed-forward methods. In particular, our method generates dense depth predictions using a monocular setup, which has not been shown previously. We pretrain our model using a new dataset containing events and depth maps recorded in the CARLA simulator. We test our method on the Multi Vehicle Stereo Event Camera Dataset (MVSEC). Quantitative experiments show up to 50% improvement in average depth error with respect to previous event-based methods. Code and dataset are available at: http://rpg.ifi.uzh.ch/e2depth.
A telerehabilitation application with pre-defined consultation classes (2014)

Advancements in telecommunication technologies have been instrumental for the past few decades in making human life easier. Development of telemedicine technology made access to better medical care for the rural population ever more possible. However, telemedicine systems for rehabilitation purposes which are designed to work under low-bandwidth network conditions are rare to find. This work focuses on developing a low-bandwidth telerehabilitation system with customised consultation classes for the user to select from, depending on the requirements. Each class, with its preset parameter values, is discussed in detail demonstrating relevant rehabilitation exercises. A novel bandwidth adaptation algorithm is also presented for optimal utilisation of the dynamic network conditions. Experiment results show that the system is able to perform effectively in each consultation scenario while performing the rehabilitation exercises. The proposed bandwidth adaptation algorithm is also verified for its ability in adapting the content quality and for effectively utilising the network under constrained conditions.
ChemInform Abstract: Regioselective Openings of 2,3‐Epoxy Acids with Organocuprates. (1986)

Abstract Die Regioselektivität der Umsetzung der Epoxy‐carbonsäuren (I) mit Dimethyllitiumcuprat (II) wird untersucht.
Injectable Hydrogels as Biomaterials (2009)

This chapter contains sections titled: Overview Introduction Injectable In Situ Forming Gels Conclusions References
COVID-19 instructional approaches (in-person, online, hybrid), school start times, and sleep in over 5,000 U.S. adolescents (2021)

These findings provide important insights regarding the association between instructional approach and school start times on the timing, amount, and variability of sleep in U.S. adolescents. Given the public health consequences of short and variable sleep in adolescents, results may be useful for education and health policy decision-making for post-pandemic secondary schools.
Inferior Turbinectomy versus Submucosal Diathermy for Inferior Turbinate Hypertrophy (2000)

In order to compare and evaluate bilateral inferior turbinectomy (BIT) and submucosal diathermy (SMD), we retrospectively examined these two well-known techniques for treatment of nasal obstruction due to bilateral congestion of the inferior turbinates. One hundred patients with bilateral nasal obstruction were divided into 4 groups according to their nasal airflow patency. Forty-nine patients underwent BIT, and 51 patients underwent SMD. All 100 patients were followed for 2 months after surgery. Patients with difficult postoperative courses were followed up to 1 year after surgery, in order to decide on the necessity of operative revision. Postoperative improvement in nasal breathing after BIT was reported for 96% of patients 2 weeks after surgery, and for 88% 2 months after surgery. Only 1 BIT patient had to undergo revision operation. Diathermy showed good results in 78% of cases 2 weeks after surgery. The efficacy of the procedure was reduced to 76% 2 months after surgery. Twenty percent of SMD patients were advised to undergo operative revision. Postoperative bleeding occurred in 20% of BIT patients and in only 4% of SMD patients. We found that the extent of postoperative improvement does not depend on preoperative conditions; therefore, it is impossible to predict the extent of postoperative improvement on the basis of the results of preoperative assessment. Both procedures can be performed under local anesthesia, are relatively safe and effective, and do not need expensive instrumentation that may not be available in many medical centers.
Isolation and characterization of catalytic and calmodulin‐binding domains of Bordetella pertussis adenylate cyclase (1991)

A truncated Bordetella pertussis cya gene product was expressed in Escherichia coli and purified by affinity chromatography on calmodulin-agarose. Trypsin cleavage of the 432-residue recombinant protein (Mr = 46,659) generated two fragments of 28 kDa and 19 kDa. These fragments, each containing a single Trp residue, were purified and analyzed for their catalytic and calmodulin-binding properties. The 28-kDa peptide, corresponding to the N-terminal domain of the recombinant adenylate cyclase, exhibited very low catalytic activity, and was still able to bind calmodulin weakly, as evidenced by using a fluorescent derivative of the activator protein. The 19-kDa peptide, corresponding to the C-terminal domain of the recombinant adenylate cyclase, interacted only with calmodulin as indicated by a shift in its intrinsic fluorescence emission spectrum or by the enhancement of fluorescence of dansyl-calmodulin. T28 and T19 fragments exhibited an increased sensitivity to denaturation by urea as compared to uncleaved adenylate cyclase, suggesting that interactive contacts between ordered portions of T28 and T19 in the intact protein participate both in their own stabilization and in stabilization of the whole tertiary structure. The two fragments reassociated into a highly active calmodulin-dependent species. Reassociation was enhanced by calmodulin itself, which 'trapped' the two complementary peptides into a stable, native-like, ternary complex, which shows similar catalytic properties to intact adenylate cyclase.
Stochastic Model for Generation of High-Resolution Irradiance Data and Estimation of Power Output of Photovoltaic Plants (2017)

This paper presents a method for the generation of synthetic time series of solar radiation with a one-minute time resolution using an automatic cloud classification procedure. Solar radiation data from ground-based measurements are used to determine the correlation between the irradiance and the prevailing cloud classes extracted from satellite images. A specific set of Markov chains for each cloud class is adjusted empirically and used for a stochastic simulation of clear sky index time series. The different models are then combined to convert the irradiance into power output time series of photovoltaic power plants of different sizes. Tests to determine the methodology's performance showed positive results in reproducing the statistical characteristics of observed time series data. Estimates of a selected set of metrics were obtained for several sites in Brazil and allowed the characterization of the solar resource for photovoltaic plants of various sizes and mounting methods considering the generation potential and short-term variability.
Terapia de recanalização endovascular de oclusão da artéria carótida em paciente com acidente vascular cerebral agudo (2008)

Relatamos o caso de uma paciente de 69 anos, que, após a realização de arteriografia carotídea, apresentou trombose sintomática da bifurcação carotídea. A paciente foi submetida imediatamente a reperfusão endovascular mecânica, com implante bem-sucedido de stent carotídeo, obtendo reversão completa do déficit neurológico.
Reduction of blowholes by vibration of the molten pool in arc welding of galvanised carbon steel sheet (1998)

Summary This paper examines measures to reduce the number of blowholes formed through vaporised zinc gas bubbles infiltrating into the molten pool through the weld gap in pulsed arc welding of galvanised carbon steel sheet with consumable electrodes by the hot metal being induced to flow along the molten pool base. Longitudinal vibration of the base metal by 1 mm during the welding process in such a way as to produce back and forth flow of the hot metal along the molten pool base leads to a significant reduction in the number of blowholes. The optimum vibration frequency giving the minimum number of blowholes is 30 Hz. This frequency is assumed to correspond to the natural vibration frequency depending on the size and physical properties of the molten pool, etc. To exert the same effect as described above by welding current control, the paper also describes an investigation of the molten pool being vibrated longitudinally by a repetitive current waveform sequence of a high peak/short time pulsed waveform group and a low peak/long time pulsed waveform group. The molten pool can also be arranged to vibrate longitudinally by control of the arc force, with blowhole generation being significantly reduced by such vibration. Vibration of the molten pool is effective for promoting the removal not only of blowholes due to the generation of vaporised zinc gas bubbles, but also supersaturation blowholes due to nitrogen formed at the solidification front.
Stability and transparency analysis of a haptic feedback controller for medical applications (2007)

This paper presents the performance analysis of a haptic feedback teleoperation system for robotic-assisted surgery. Through a haptic device, the surgeon tele-operates the medical instrument, fixed on a remote robot that may evolve in free space or in contact. In free space, the surgeon feels the motion of the robot. When contact with tissues occurs, an on-line environment stiffness estimation is performed using an extended Kalman filter with robot modeling error compensation and without considering the contact position. The quality of the telepresence will depend on this estimation. Based on the stability and transparency frequency analysis, the estimated parameter is used to tune the teleoperation scheme and to improve telepresence. The improvement is based on the stability of the haptic feedback teleoperation scheme new rearrangement in which we distinguish between voluntary and involuntary operator positions.
RIEMS: a software pipeline for sensitive and comprehensive taxonomic classification of reads from metagenomics datasets (2015)

RIEMS has the potential to fill the gap that still exists with regard to data analysis for metagenomics studies. The usefulness and power of RIEMS for the analysis of genuine sequencing datasets was demonstrated with an early version of RIEMS in 2011 when it was used to detect the orthobunyavirus sequences leading to the discovery of Schmallenberg virus.
Copolymerization of Ethylene and Vinyl Amino Acidic Ester Catalyzed by Titanium and Zirconium Complexes (2015)

A series of titanium and zirconium complexes with ligands based on di-isopropyl phosphorus-phenylamine and their derivatives were synthesized and characterized. These catalysts were utilized to catalyze the copolymerization of ethylene with N-acetyl-O-(dec-9-enyl)-L-tyrosine ethyl ester with high catalytic activity of 6.63 × 104 g P (mol Ti)−1 h−1 after activation by methylaluminoxane (MAO). The effects of ligand structure, metal atoms (Ti, Zr) and polymerization conditions were investigated in detail. The obtained polymers were characterized by 13C-NMR, DSC, FT-IR, and GPC. The results showed that the obtained copolymer had a high comonomer incorporation rate of 2.56 mol % within the copolymer chain. The melting temperature of the copolymer was up to 138.9 °C, higher than that of the obtained homopolyethylene.
Abdominal obesity (1998)

The application of magnetic resonance imaging and computed tomography to obesity research has changed the focus from body mass and skinfold thickness to abdominal fat mass and visceral adiposity. Intra-abdominal fat constitutes less than 20% of total body fat but is a major determinant of fasting and postprandial lipid availability because of its physiological (lipolytic rate and insulin resistance) and anatomical (portal drainage) properties. High levels of serum free fatty acids, as a result of abdominal obesity, cause excessive tissue lipid accumulation and contribute to dyslipidaemia, beta cell dysfunction, and hepatic and peripheral insulin resistance. An individual's risk of non-insulin dependent diabetes mellitus and cardiovascular disease relates closely to the inheritance of central obesity and susceptibility to tissue lipotoxicity.
Surface-enhanced Raman spectroscopy (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface-enhanced Raman spectroscopyRobin L. GarrellCite this: Anal. Chem. 1989, 61, 6, 401A–411APublication Date (Print):March 15, 1989Publication History Published online22 September 2008Published inissue 15 March 1989https://pubs.acs.org/doi/10.1021/ac00181a001https://doi.org/10.1021/ac00181a001research-articleACS PublicationsRequest reuse permissionsArticle Views2236Altmetric-Citations245LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An analysis of three approaches to the helicopter preliminary design problem. (1984)

Three methodologies from which to approach the problem of preliminary helicopter design are explored in this paper. The first is a sensitivity analysis of the basic helicopter performance equations. The purpose here is to ascertain where resonable simplifications can be made that do not seriously degrade the accuracy of the results. The second is a graphical parametric design method, known as Carpet Plots. In this method a graphical solution is developed to meet the design criteria of the helicopter. In the third, an overview of Boeing Vertol's Helicopter Sizing and Performance Computer Program is given. The computer routines which enable a person to access HESCOMP on the Naval Postgraduate School main frame IBM system are also provided.
Inhibition of Growth and Induction of Differentiation of Glioma Cell Lines by Oncostatin M (OSM) (1998)

The neuropoietic cytokines of the interleukin-6 family are a group of structurally and functionally related polypeptides. We studied the effect of the multifunctional neuropoietic cytokines, including oncostatin M (OSM), leukemia inhibitory factor (LIF) and interleukin-6 (IL-6), on anaplastic glioma cell lines. Growth and morphology of the glioma cell lines were affected differently. While IL-6 and LIF exerted no or only small minor morphological changes and growth retardation, OSM induced a marked change in morphology and a strong suppression of growth. OSM treated cells were characterized by enlargement and the formation of multiple, thin processes thus resembling mature cultured astrocytes. The growth inhibitory effects were dose dependent with a maximum exerted by addition of 50 ng/ml OSM. The inhibition of DNA synthesis by OSM could be abolished by antibodies blocking either the activity of OSM or the OSM-receptor component, gp130.
ChemInform Abstract: EQUILIBRIUM STUDIES WITH THE URANYL ION. NITROGEN BASES AND URANYL HEXAFLUOROACETYLACETONATES (1981)

Abstract Austauschgleichgewichte zwischen dem THF‐Komplex von Uranyl‐.