gebhart/patrepeval huggingface dataset:
Integrating Liberal Arts Learning Outcomes in the Development and Implementation of a Multisection Undergraduate Public Health Capstone Course (2016)

As demand increases for well-trained public health professionals, academic leaders of universities and colleges must tailor their curricula to prepare students to be ready for the public health workplace, while also providing critical thinking and awareness skills through a liberal arts course context. Temple University’s undergraduate public health program has created a capstone experience that bridges these two priorities. Using public health community-based program planning and evaluation as its content, this two-semester (32 weeks) writing-intensive course provides training for students in writing a grant proposal, including conducting a needs assessment, devising evaluable program goals and objectives, creating an intervention and planning its implementation and evaluation, and developing budgeting and marketing plans. Students also complete related assignments that help develop the critical thinking skills they need to understand the context of public health within the larger society. Utilizing the LEAP Essential Learning Outcomes, we infuse integrative, interdisciplinary, and applied knowledge with the concept of civic responsibility as pathways for ensuring learning, while still providing concrete skills related to public health practice. We discuss how the course is implemented and how public health practice and liberal arts learning objectives are emphasized to ensure an “educated citizenry.” Universities and colleges that offer an undergraduate degree in public health can use this framework to implement a capstone experience that bridges both public health and liberal arts skills.
Solarthermal Processing: A Review (2000)

Research on solarthermal processing and the need for alternative energy sources have reached the point where efforts to develop some industrial processes and expand research to suggest others are at least desirable, if not imperative. This paper presents a rationale for such an effort, describes the underlying thermodynamics, and summarizes much of the research which has been conducted in the years since the end of World War II. Major emphasis is placed on the work that has been done since the imposition of the 1973 oil embargo and the present.
Maximization of Markers Linked in Coupling for Tetraploid Potatoes via Monoparental Haploids (2018)

Haploid potato populations derived from a single tetraploid donor constitute an efficient strategy to analyze markers segregating from a single donor genotype. Analysis of marker segregation in populations derived from crosses between polysomic tetraploids is complicated by a maximum of eight segregating alleles, multiple dosages of the markers and problems related to linkage analysis of marker segregation in repulsion. Here, we present data on two monoparental haploid populations generated by prickle pollination of two tetraploid cultivars with <i>Solanum phureja</i> and genotyped with the 12.8 k SolCAP single nucleotide polymorphism (SNP) array. We show that in a population of monoparental haploids, the number of biallelic SNP markers segregating in linkage to loci from the tetraploid donor genotype is much larger than in putative crosses of this genotype to a diverse selection of 125 tetraploid cultivars. Although this strategy is more laborious than conventional breeding, the generation of haploid progeny for efficient marker analysis is straightforward if morphological markers and flow cytometry are utilized to select true haploid progeny. The level of introgressed fragments from <i>S. phureja</i>, the haploid inducer, is very low, supporting its suitability for genetic analysis. Mapping with single-dose markers allowed the analysis of quantitative trait loci (QTL) for four phenotypic traits.
Core–Multishell Magnetic Coordination Nanoparticles: Toward Multifunctionality on the Nanoscale (2008)

Epitaxiales Aufwachsen eines Koordinationsnetzwerks mit Cyanidbrücken auf Kernpartikeln erzeugt Kern-Schale-Nanopartikel. Die Schalendicke lässt sich im Nanometerbereich einstellen, und der Prozess kann mit unterschiedlichen Metallionen wiederholt werden, um Partikel mit mehreren Schalenschichten und kombinierten magnetischen Eigenschaften zu erhalten (siehe Bilder). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Taiwan’s 2014 Nine-in-One Election: Gauging Politics, the Parties, and Future Leaders (2014)

On Saturday November 29, 2014 voters in Taiwan (officially known as the Republic of China) went to the polls to cast ballots for mayors and city council members of the metropolitan cities, mayors and councilors of the counties and provincial cities, town- ship chiefs and councilors, aboriginal district chiefs and councilors, and borough and village chiefs. Sometimes called Taiwan’s “midterms”, these combined elections are held at four-year intervals, scheduled in between its national presidential/vice presidential and legislative elections. The midterms are now considered nearly as important as the latter elections, one of the reasons being as of 2014 all local elections are held at the same time. Students of Taiwan’s elections viewed the Democratic Progressive Party (DPP), for reasons inherent in the party’s makeup and philosophy, perennial disunity, and serious disagreements about the party’s stances toward China and the United States, as incapable of appealing to a broad segment of Taiwan’s electorate. This meant the KMT had an advantage. However, the Kuomintang (KMT) appeared fully capable of losing the election as reflected by the performances of a number of its members in the legislature, President Ma and his administration’s low popularity, and what many considered its poor record in governance. In addition, serious factionalism and centrifugal tendencies plagued the Ma administration and the Nationalist Party, and both lost ground on important issues to voters such as economic management, corruption, political reform, and some other matters that influenced voters. As the votes were counted, the media, election observers, and party leaders gave the victory with few caveats to the DPP and reported it was a loss for the KMT. In fact, most saw the election results as proof it was a big, even momentous, win for the DPP and a shellacking for the KMT. Many opined the election would have very profound consequences, including making it likely the DPP would win the 2016 election or elections. It would also impact relations with China and the United States. Finally, a majority of observers saw it as a plus for Taiwan’s democracy. This article evaluates these observations and predictions.
Software issues in high-performance computing and a framework for the development of HPC applications (1994)

No abstract available.
Effects of dose and application timing on the seed production of three weed species treated with MCPA or tribenuron‐methyl (1995)

Summary The seed production of Fallopia convolvulus (L.) A. Love, Galium spurium L, and Thlaspi arvense L., treated with MCPA or tribenuron‐methyl, was studied in a pot experiment. The herbicides were applied in doses from 1/16 to 1/l of a full dose at five different growth stages. The largest reduction of seed production was observed on plants treated when one true leaf had developed ( F. convolvulus , both herbicides) or at the beginning of the generative phase ( G. spurium treated with tribenuron‐methyl and T. arvense treated with either herbicide). Tribenuron‐methyl (0.375 g a.i. ha −1 ) or MCPA (0.1875 kg a.i. ha −1 ) applied at bolting stage was enough to reduce the seed production of T. arvense by 83% and 100%, respectively. The seed production of F. convolvulus , treated with 0.75 kg MCPA at the cotyledon stage, was reduced by 70%. Plants of G. spurium with 5–9 axillary shoots, treated with 3 g tribenuron‐methyl, produced 45% fewer seeds than the control. Both herbicides (at least at the highest doses) reduced seed production of all three species more than shoot dry matter.
Need and Potential Use of Information Technology for Case Manager–Physician Communication in Home Care (2012)

Case management has become a popular model for providing home care services to nursing home-eligible older adults. To maximize collaborative decision making and patient outcomes, members of the case management team must engage in ongoing, open communication. However, little is known about the quality of communication between home care case managers and their clients’ physicians. This study examined geriatric home care case managers’ perceptions of their communication with their clients’ physicians. Participating case managers were employed at two large home care agencies located in the South Florida region. The findings suggest that communication between home care case managers and physicians is limited and inefficient. Implication for policy and practice are provided. Finally, we propose ways to leverage Information Technology to bridge this communication gap.
Multichannel adaptive filtering using an efficient matching pursuit-like algorithm for removal of CPR artifacts in ECG signals (2002)

In this contribution we present a novel algorithm for multichannel adaptive filtering. The algorithm is based on selective update of filter coefficients using a matching pursuit-like strategy operating on a time varying “dictionary” given by the current multichannel data matrix. The algorithm has low computational complexity and is robust in rank deficient situations. We present the adaptive filter in an application oriented setting in which the objective is to remove artifacts in electrocardiograms (ECG) resulting from cardiopulmonary resuscitation (CPR). We present simulation results on realistic data showing the superior performance of the algorithm.
Magnetization and spin-echo spectra of a mixing-type quadrupolar ordering in YbSb (2003)

Magnetization and nuclear magnetic resonance spin-echo spectra were measured to investigate a quadrupolar ordering in YbSb.The width of the spin-echo spectra increases with applied magnetic field significantly, below a quadrupolar ordering temperature (TQ). On the other hand, magnetization processes do not show any noticeable changes at TQ. A model calculation using the molecular field approximation shows that the ferromagnetic components do not show a significant change, while antiferromagnetic components are induced strongly below TQ in a magnetic field, which is qualitatively consistent with the experimental results. Furthermore, it is suggested that eqQ broadening of the spin-echo spectra is dominant at low magnetic field.
Electronic Endoscopy - The Latest Technology (1987)

At present, video endoscopic systems (VE) are available from four companies. We have had an opportunity to test these instruments in clinical practice. In principle, all the VE's are similar in that they employ charge coupling devices (CCD-chips) as image sensors, but they differ significantly in CCD chip technology and in the color acquisition technique. The basic aspects of CCD chip and transmission technology of relevance to the endoscopist are discussed. The mechanical properties of the endoscopes are listed. Finally, we provide an outlook on the determinants of the optical performance of VE's. The optical performance of a VE can be characterized by its resolution and color performance.
Immunoaffinity chromatographic and immunoprecipitation methods combined with mass spectrometry for characterization of circulating transthyretin (2006)

Transthyretin (TTR) is a small serum protein that is involved in distinct phenotypes of amyloidosis with different tissue localization, age of onset, and rate of progression. Some types of TTR-amyloidosis (such as familial amyloid polyneuropathy) are associated with various amino acid point mutations, while cardiac amyloid myopathy may also be associated with precipitation of the wild-type molecules, e.g., in senile systemic amyloidosis. Because of the unsettled relationship between circulating and precipitated TTR we here explore on-line immunoaffinity (IA) chromatography-MS and immunoprecipitation (IP)-MS methods for characterizing the circulating TTR population in normal individuals and in patients with known TTR-amyloidosis. It was found necessary to reduce the samples, e.g., with DTT, prior to ESI-TOF-MS. This reversed oxidative modifications to sufficiently resolve the two mass peaks isolated from sera of heterozygous patients. A simple IP technique without the use of centrifugal filtration was found to be convenient for the assessment of the TTR population in serum as demonstrated for both normal and variant (the Met111Leu mutation) TTR. This approach also readily allowed the identification of oxidation, S-sulfation, and S-cysteinylation in unreduced samples, while these modifications were less well resolved in the on-line IA chromatography-MS approach.
Bacterial antimicrobial metal ion resistance (2014)

Metals such as mercury, arsenic, copper and silver have been used in various forms as antimicrobials for thousands of years with until recently, little understanding of their mode of action. The discovery of antibiotics and new organic antimicrobial compounds during the twentieth century saw a general decline in the clinical use of antimicrobial metal compounds, with the exception of the rediscovery of the use of silver for burns treatments and niche uses for other metal compounds. Antibiotics and new antimicrobials were regarded as being safer for the patient and more effective than the metal-based compounds they supplanted. Bacterial metal ion resistances were first discovered in the second half of the twentieth century. The detailed mechanisms of resistance have now been characterized in a wide range of bacteria. As the use of antimicrobial metals is limited, it is legitimate to ask: are antimicrobial metal resistances in pathogenic and commensal bacteria important now? This review details the new, rediscovered and 'never went away' uses of antimicrobial metals; examines the prevalence and linkage of antimicrobial metal resistance genes to other antimicrobial resistance genes; and examines the evidence for horizontal transfer of these genes between bacteria. Finally, we discuss the possible implications of the widespread dissemination of these resistances on re-emergent uses of antimicrobial metals and how this could impact upon the antibiotic resistance problem.
Optical sensors based on monolithic integrated organic light-emitting diodes (OLEDs) (2008)

Organic light-emitting diodes (OLEDs) permit the monolithic integration of microelectronic circuits and light-emitting devices on the same silicon chip. By the use of integrated photodetectors, low-cost CMOS processes and simple packaging; economically produced optoelectronic integrated circuits (OEICs) with combined sensors and actuating elements can be realized. The OLEDs are deposited directly on the top metal layer. The metal layer serves as electrode and defines the bright area. Furthermore, the area below the electrodes can be used for integrated circuits. Due to efficient emitter with low operating voltage it is possible to renounce high-voltage devices depending on selected CMOS process. Thus manufacturing cost can be further reduced. Different CMOS metallizations were examined and their effects on organic light-emitting diodes were analyzed. Red (628nm) and orange (597nm) emitting p-i-n OLEDs with a radiance of 5W/m<sup>2</sup>sr at 2.8V and 3.0V and a half angle of &plusmn;45&deg; were realized on metal layer with low roughness. Near infra-red emitters are in development. We will present an optical microsystem. The functionality of combined sensors and actuating elements as well as advantages and difficulties of the monolithic integration of OLEDs and CMOS will be discussed. The chip was manufactured in a commercial 1&mu;m CMOS technology. The fabricated microsystem combines three different types of sensors: a reflective sensor, a colour sensor and a particle flow sensor.
Mechanism-Based Inhibition of Sir2 Deacetylases by Thioacetyl-Lysine Peptide (2007)

Sir2 protein deacetylases (or sirtuins) catalyze NAD+-dependent conversion of epsilon-amino-acetylated lysine residues to deacetylated lysine, nicotinamide, and 2'-O-acetyl-ADP-ribose. Small-molecule modulation of sirtuin activity might treat age-associated diseases, such as type II diabetes, obesity, and neurodegenerative disorders. Here, we have evaluated the mechanisms of sirtuin inhibition of histone peptides containing thioacetyl or mono-, di-, and trifluoroacetyl groups at the epsilon-amino of lysine. Although all substituted peptides yielded inhibition of the deacetylation reaction, the thioacetyl-lysine peptide exhibited exceptionally potent inhibition of sirtuins Sirt1, Sirt2, Sirt3, and Hst2. Using Hst2 as a representative sirtuin, the trifluoroacetyl-lysine peptide displayed competitive inhibition with acetyl-lysine substrate and yielded an inhibition constant (Kis) of 4.8 microM, similar to its Kd value of 3.3 microM. In contrast, inhibition by thioacetyl-lysine peptide yielded an inhibition constant (Kis) of 0.017 microM, 280-fold lower than its Kd value of 4.7 microM. Examination of thioacetyl-lysine peptide as an alternative sirtuin substrate revealed conserved production of deacetylated peptide and 1'-SH-2'-O-acetyl-ADP-ribose. Pre-steady-state and steady-state analysis of the thioacetyl-lysine peptide showed rapid nicotinamide formation (4.5 s-1) but slow overall turnover (0.0024 s-1), indicating that the reaction stalled at an intermediate after nicotinamide formation. Mass spectral analysis yielded a novel species (m/z 1754.3) that is consistent with an ADP-ribose-peptidyl adduct (1'-S-alkylamidate) as the stalled intermediate. Additional experiments involving solvent isotope effects, general base mutational analysis, and density functional calculations are consistent with impaired 2'-hydroxyl attack on the ADP-ribose-peptidyl intermediate. These results have implications for the development of mechanism-based inhibitors of Sir2 deacetylases.
Seeding of Perovskite Lead Magnesium Niobate Crystallization from Pb‐Mg‐Nb‐EDTA Gels (1999)

The addition of BaTiO 3 seed particles (50 nm in diameter) to a Pb‐Mg‐Nb‐EDTA solution (where EDTA represents ethylenediamine tetraacetic acid) reduces the formation temperature from 700°C to 600°C during combustion synthesis, because of epitaxial effects. The lower perovskite formation temperature eliminates the formation of pyrochlore at the surface of the precursor bed and allows for the direct crystallization of ∼98% perovskite lead magnesium niobate (PMN) during combustion synthesis. Increasing the nucleation density of the seed particles in the seeded precursor decreases the precursor volume that is associated with each perovskite nucleus and, thus, reduces the PMN particle size from 1 µm to 0.2 µm. The influence of BaTiO 3 seeding is discussed in terms of the thermodynamics of perovskite formation, the influence of BaTiO 3 seed concentration, and epitaxial nucleation.
Role of the DNA Binding Domain of C/EBP$\varepsilon$ on Granulopoiesis (2005)

Background: The CCAAT/enhancer binding protein epsilon (C/EBP), one of the transcription factors, plays an important role in granulopoiesis. We examined an essential site of C/EBP for granulopoiesis. Methods: 32D cells and #1111 cells were transduced with retroviral constructs of C/EBP and C/EBP (DNA binding mutant form). We examined growth rate, checked the neutrophil markers of Gr-1 and Mac-1, and counted differentiated cells in the transduced 32D cells. The transduced #1111 cells were injected into five mice and survival times were analyzed. Results: The mean number of green fluorescent protein (GFP) (+) 32D cells transduced with C/EBP was 244,045 at day 2, 582,938 at day 4, and 873,963 at day 6; mean expression of Gr-1 was 31.3% and Mac-1 32.6%; mean count of immature form was 41.0%, intermediate form 48.3%, and mature form 10.7%. In case of C/EBP transduced 32D cells, the respective figures were 707,226, 1,106,736, and 2,133,819; 0.1% and 0.1%; and 91.7%, 4.3%, and 4.0%. The mean survival time of #1111 cells transduced with C/EBP was 26.0 days in placebo group and 34.0 days in 4- hydroxytamoxifen (4HT; C/EBP group); in case of C/EBP transduced #1111 cells, the respective figures were 36.4 and 37.4 days. Conclusion: The growth of 32D and #1111 cells was inhibited by C/EBP , but not by C/EBP. Also C/EBP was involved in the differentiation of 32D cells, but C/EBP was not. The DNA binding domain of C/EBP is a very important site for differentiating and inhibiting early myeloid cells.
Inducer-dependent conditional-lethal mutant animal viruses. (1991)

Regulatory elements of the Escherichia coli lac operon were used to construct an inducer-dependent conditional-lethal mutant animal virus. The gene encoding the repressor protein of the lac operon was integrated into the vaccinia virus genome so that it was expressed constitutively, and the lac operator was inserted next to the promoter of a gene that encodes an 11-kDa virion-associated protein of unknown function. The addition of inducer to the cell culture medium provided permissive conditions for isolation of a conditional-lethal mutant virus. Under nonpermissive conditions, the isolated virus did not form plaques, and the yield was decreased by at least 1000-fold under one-step growth conditions. Transcription of the operator-controlled gene was inducer-dependent and necessary for synthesis of the 11-kDa protein. Application of this mutagenesis strategy to other viruses is discussed.
Targeting Oxidative Phosphorylation to Increase the Efficacy of Radio- and Immune-Combination Therapy (2021)

As tumors grow, they upregulate glycolytic and oxidative metabolism to support their increased and altered energetic demands. These metabolic changes have major effects on the tumor microenvironment. One of the properties leading to this aberrant metabolism is hypoxia, which occurs when tumors outgrow their often-chaotic vasculature. This scarcity of oxygen is known to induce radioresistance but can also have a disrupting effect on the antitumor immune response. Hypoxia inhibits immune effector cell function, while immune cells with a more suppressing phenotype become more active. Therefore, hypoxia strongly affects the efficacy of both radiotherapy and immunotherapy, as well as this therapy combination. Inhibition of oxidative phosphorylation (OXPHOS) is gaining interest for its ability to combat tumor hypoxia, and there are strong indications that this results in a reactivation of the immune response. This strategy decreases oxygen consumption, leading to better oxygenation of hypoxic tumor areas and eventually an increase in immunogenic cell death induced by radio-immunotherapy combinations. Promising preclinical improvements in radio- and immunotherapy efficacy have been observed by the hypoxia-reducing effect of OXPHOS inhibitors and several compounds are currently in clinical trials for their anticancer properties. Here, we will review the pharmacologic attenuation of tumor hypoxia using OXPHOS inhibitors, with emphasis on their impact on the intrinsic antitumor immune response and how this affects the efficacy of (combined) radio- and immunotherapy.