gebhart/patrepeval huggingface dataset:
Synergetic Material and Structure Optimization Yields Robust Spider Web Anchorages (2013)

Millions of years of evolution have adapted spider webs to achieve a range of properties, including the well-known capture of prey, with efficient use of materials. One feature that remains poorly understood is the attachment disc, a network of silk fibers that mechanically anchors a web to its environment. Experimental observations suggest that one possible attachment disc adheres to a substrate through multiple symmetrically branched structures composed of sub-micrometer scale silk fibers. Here, a theoretical model is used to explore the adaptation of the strength of attachment of such an anchorage, and complementary mesoscale simulations are applied to demonstrate a novel mechanism of synergetic material and structural optimization, such that the maximum anchorage strength can be achieved regardless of the initial anchor placement or material type. The optimal delamination (peeling) angle is facilitated by the inherent extensibility of silk, and is attained automatically during the process of delamination. This concept of self-optimizing peeling angle suggests that attachment discs do not require precise placement by the spider, irrespective of adhesion strength. Additional hierarchical branching of the anchorage increases efficiency, where both the delamination force and toughness modulus increase with a splitting of the cross-sectional area.
The SIMBA user alert service architecture for dependable alert delivery (2002)

Alerts refer to the delivery of user-subscribed information to the user. As the number of alert services and the types of information delivery devices increase, a new model that allows users to manage alert delivery and avoid alert overflow is needed. The unique dependability challenge in the management of alerts is in the proper use of redundancy to achieve timeliness and reliability without being unduly intrusive or cumbersome. We describe the design, implementation, and user experience of an alert service architecture, called SIMBA. SIMBA utilizes Instant Messaging with acknowledgements as the universal, reliable alert delivery channel, with emails being the fallback channel. All alerts that a user subscribes to are first directed to the user's MyAlertBuddy, which allows centralized delivery preference customization and acts as a personal alert router to protect the privacy of user addresses. Delivery modes, each of which involves multiple user addresses to accommodate communication failures, are supported as an abstraction for specifying personalized dependability levels. A working implementation of the SIMBA system, which integrates five different types of alert services, is described. Challenges and techniques in maintaining a highly available MyAlertBuddy to avoid single-point of failure are discussed. The concept of exception handling automation is introduced for enhancing the robustness of applications that drive third-party communication client software through automation interfaces.
Summary Abstract: Styrene and vinyldimethylethoxysilane plasma polymerization and plasma copolymerization (1984)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation G. W. Prohaska, J. F. Evans; Summary Abstract: Styrene and vinyldimethylethoxysilane plasma polymerization and plasma copolymerization. J. Vac. Sci. Technol. A 1 April 1984; 2 (2): 380–381. https://doi.org/10.1116/1.572747 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science & Technology A Search Advanced Search |Citation Search
Arterial stiffness is associated with low skeletal muscle mass in Japanese community‐dwelling older adults (2014)

Our data showed that arterial stiffness is associated with low SMI in community-dwelling older adults, even when adjusting by multiple factors, showing a close interaction of vascular aging and muscle mass decline.
The cellular homologue of the transforming gene of SKV avian retrovirus maps to human chromosome region 1q22→q24 (1986)

We report the chromosomal localization of the cellular oncogene SKI, the putative oncogene of the Sloan-Kettering viruses (SKVs), a group of transforming retroviruses that had been isolated from chicken embryo cells infected with the avian leukosis virus tdB77. Southern blot analysis of DNA from mouse X human somatic cell hybrids with the v-SKI probe established synteny with chromosome 1, but excluding the region 1pter----q21. In situ hybridization of the same probe both to human spermatocyte pachytene and lymphocyte metaphase chromosomes enabled precise localization of the gene to the region 1q22----q24, a region that frequently is involved in translocations and other rearrangements in diverse human tumor types. In situ hybridization studies of metaphase spreads from a small noncleaved cell lymphoma that exhibited a t(1;14)(q21;q32) translocation showed that SKI translocates to the der(14) chromosome. Cytogenetic analysis of 65 prospectively ascertained non-Hodgkin's lymphomas revealed that the SKI region undergoes nonrandom breakage leading to translocations. Further analysis of the chromosome breaks in this group of lymphomas suggested that those involving the SKI site probably are of importance in tumor progression.
CYP2C19 Loss‐of‐function Polymorphisms are Associated with Reduced Risk of Sulfonylurea Treatment Failure in Chinese Patients with Type 2 Diabetes (2021)

Sulfonylureas (SUs) are predominantly metabolized by cytochrome p450 2C9 (CYP2C9) and cytochrome p450 2C19 (CYP2C19) enzymes. CYP2C9 polymorphisms are associated with greater treatment response and hypoglycemic risk in SU users. However, there are no large scale pharmacogenetic studies investigating the effect of loss-of-function alleles CYP2C19*2 and CYP2C19*3, which occur frequently in East Asians. Retrospective pharmacogenetic analysis was performed in 11,495 genotyped patients who were enrolled in the Hong Kong Diabetes Register between 1995 and 2017, with follow-up to December 31, 2019. The associations of CYP2C19 polymorphisms with SU treatment failure, early HbA1c response, and severe hypoglycemia were analyzed by Cox regression or logistic regression assuming an additive genetic model. There were 2341 incident SU users that were identified (mean age 59 years, median diabetes duration 9 years), of which 324 were CYP2C19 poor metabolizers (CYP2C19 *2/*2 or *2/*3 or *3/*3). CYP2C19 poor metabolizers had lower risk of SU treatment failure (hazard ratio 0.83, 95% confidence interval (CI) 0.72-0.97, P = 0.018) and were more likely to reach the HbA1c treatment target < 7% (odds ratio 1.52, 95% CI 1.02-2.27, P = 0.039) than wild-type carriers (CYP2C19 *1/*1) following adjustment for multiple covariates. There were no significant differences in severe hypoglycemia rates among different CYP2C19 genotype groups. CYP2C19 polymorphisms should be considered during personalization of SU therapy.
Taeger, Angela (2016): Die Guillotine und die Erfindung der Humanität. Stuttgart: Kohlhammer, 143 S. (2021)

Die Guillotine ist eine Apparatur voller Spannungen und Widersprüche. Ikonographisch steht sie für die blutige Seite der französischen Revolution. Die Guillotine schuf Tatsachen. War die große Revolution in Frankreich der Geburtsakt der Moderne, so zerschnitt die Guillotine die Nabelschnur zur Vergangenheit. Mochten kommende Reaktionäre auch immer wieder versuchen, Legitimationsfäden ins vermeintlich glorreiche Gestern zurückzuspinnen, so blieb doch die Narbe, die die dreieckige Klinge geschlagen hatte, bestehen. Dies galt auch dann, wenn keineswegs ausschließlich oder auch nur vorrangig Anhänger des Ançien Regime auf dem ,,Blutgerüst“ starben. Unter dem Fallbeil endeten der Bürger Louis Capet und seine Witwe ebenso wie Girondisten, Hèbertisten, Dantonisten und schließlich auch der unbestechliche Robespierre und sein vielleicht glühendster Anhänger Saint-Just. Dass sich die terreur der Revolution nicht zuletzt gegen die Revolutionäre richtete, gehört zum klassischen Problembestand der Revolutionstheorie und -historiographie. Die Guillotine ist zum Sinnbild dieser Verwicklungen geworden.
Carboxylate Group Side-Chain Density Modulates the pH-Dependent Optical Properties of PPEs (2007)

The synthesis of two new water-soluble, carboxylate-substituted poly(p-phenyleneethynylene)s (PPE) is reported. These PPEs differ in their concentration of free carboxylate groups per repeat (two aryleneethynylenes) unit. The photophysical properties of these two polymers are compared to each other and to that of the known dicarboxylate-PPE. An increasing concentration of carboxylate groups (on a per repeat basis) makes the polymers less fluorescent but also more sensitive toward quenching by mercury ions. The least carboxylate functionalized PPE shows the highest quantum yield (0.33). All three PPEs are pH-sensitive and show dramatic changes in absorption and emission at around pH 3.5, which is the pKa of methoxyacetic acid, the common structural subunits in all of these PPEs.
Effect of multidrug resistance-conferring mutations on the fitness and virulence of Pseudomonas aeruginosa (2011)

Specific resistance mutations were associated with fitness cost in P. aeruginosa, and accumulation of such mutations was associated with a reduction in virulence. However, it was difficult to predict the impact in clinical isolates. Knowledge of multidrug resistance mechanisms and compensatory mutations would likely be helpful.
Platelet-Collagen Interaction (1976)

Type I collagen from calf skin, collagen modified by pepsin treatment, methylation, succinylation or deamidation, as well as the alpha-chains and cyanogen bromide peptides of the alpha1-chain were investigated with respect to their capacity to induce aggregation of human platelets. These preparations permitted an evaluation of the efficacy of the amino acid sequence, triple conformation,and various fibrillar structures in platelet aggregation. All collagens in dissolved in dissolved form (collagen dissolved at acid pH, pepsin-treated, methylated, deamidated, and succinylated collagen) induced platelet aggregation only after fibril formation. The arrangement of molecules within fibrils is of secondary importance. Modification of the side chains of amino acid residues affects primarily the formation of fibrils. The effect of these side chains on platelet aggregation is masked by the overwhelming potency of the fibrillar forms.
ChemInform Abstract: TRI‐P‐TOLYL PHOSPHATE COMPLEXES WITH METAL CHLORIDES AND PERCHLORATES (1979)

Abstract Die stöchiometrische Umsetzung des Titelliganden mit den entsprechenden Metallchloriden oder ‐perchloraten in Methanol oder Methanol/Aceton und darauffolgende Dehydratisierung durch Erwärmen mit Triethylorthoformiat führen zu den monomeren und dimeren high‐spin‐Komplexen (I) und (II) bzw. (III)‐(V).
Prediction of postoperative survival by preoperative serum concentrations of anti-p53 compared to CEA, CA 50, CA 242 and conventional blood tests in patients with colorectal carcinoma (2002)

Blood samples were obtained preoperatively from 151 consecutive patients who were operated for colorectal carcinoma; of these 132 patients underwent curatively aimed operations. Patients who lived for more than five years without any evidence of relapse were classified as survivors and those who died during follow-up were classified as non-survivors. Tumors were staged according to Dukes and tumor differentiation was classified as high, intermediate or low. Serum anti-p53 was determined in all patients and compared to CEA, CA 50 and CA 242 in serum as well as to blood hemoglobin concentration (Hb), erythrocyte sedimentation rate (ESR), serum alkaline phosphatases (ALP), in the same preoperative blood samples for comparison of power to predict mortality in colorectal cancer. Tumor differentiation and Dukes classification predicted survival and the risk to die of colorectal carcinoma as expected. CA 242 and anti-p53 titers in serum were not significantly different among groups of patients with Dukes A-D tumors, while Hb, ESR, ALP, CEA and CA 50 were significantly different with increasing levels appearing in Dukes C-D, except for Hb which decreased. Survivors had lower ESR, ALP, CEA, CA 50 and CA 242, while Hb and serum anti-p53 titers were not different among survivors and non-survivors. Survivors among Dukes A-C patients had normal Hb, ESR, ALP and CA 242 before operation, while non-survivors had increased ESR, CEA and CA 50. Levels of anti-p53 were unrelated to concentrations of all other blood and serum variables, and did not predict survival in Dukes A-D patients. Serum levels of CEA and CA 50 displayed a significantly altered distribution among survivors and non-survivors (p<0.01). This altered distribution was independent of Dukes A-C tumor stage for CEA (p<0.05) but not for CA 50. Based on these results, we conclude that patients with CEA levels above 15 ng/ml should be regarded as high risk patients even when their tumors are classified as Dukes B. These patients may benefit from neoadjuvant or adjuvant chemotherapy.
Time-varying communication channels: Fundamentals, recent developments, and open problems (2006)

In many modern wireless communication systems, the as-sumption of a locally time-invariant (block-fading) channel breaks down due to increased user mobility, data rates, and carrier frequencies. Fast time-varying channels feature sig-nificant Doppler spread in addition to delay spread. In this tutorial paper, we review some characterizations and sparse models of time-varying channels. We then discuss several models and methods recently proposed for communications over time-varying wireless channels, and we point out some related open problems and potential research directions. 1.
Mechanism for thermal poling in twin-hole silicate fibers (2002)

Thermal poling and depoling current for twin-hole fibers was measured. The current’s evolution was compared with electro-optic evolution. The thermally stimulated discharge efficiency was measured to be 5%. Atomic-force microscopy was used to study the HF-etched transverse sections of thermally poled twin-hole fiber. Thermal poling modified the etch rate in two rings about the anode hole. The outer ring was found to move with time, whereas the inner ring’s position was stationary. Results are explained by use of a space-charge model that comprises two components: movement of impurity ions and charge injection in which the charge injection component dominates the poling characteristics.
Enantioselective Allylation of Imines Directed by Phenols (2007)

The use of a phenol-directing group activates the allylation reagent 2, thus providing access to chiral homoallylic amines under simple reaction conditions. The phenol moiety can either be used as a protecting group and oxidatively cleaved in the case of aldimines 1 and 4, or it can be part of the molecule, as for ketimines like 7. Noteworthy is the rapid one-pot synthesis of functionalized cyclic chiral amines. Indeed, upon addition of Grubbs II catalyst to the reaction mixture of 8, enantiopure heterocycles bearing tertiary carbin­amines are obtained efficiently (82-90%, 96-98% ee).
Hard X-Ray Observations of Hercules X-1 by OSO-7 (1972)

The UCSD X-ray telescope on the oSO-7 scanned the periodic variable X-ray source Her X-1 from 1972 May 30 to 1972 June 1. Analysis of the quick-look data in the 7-26 keV range shows low intensity at 12 2 hours UT, 1972 May 31, which is ezpected from the previously determined 1.7-day period. The source was observed in its high-intensity state 30 hours earlier than predicted from the Uhitru determination of the s5.7-day period and its phase. The spectrum over the 240 keV range in the high-intensity state can be fitted by 0.2S/E'. photons (cm2 5 kev) 1
New Findings in Fracture Cleanup Change Common Industry Perceptions (2006)

Abstract This paper summarizes part of the results of an investigation of fracture clean-up mechanisms undertaken under a Joint Industry Project active since the year 2002. It is well documented in the literature that hydraulic fractures, although successful, often underperform: Frac and Pack completions exhibit positive skin values, and traditional hydraulic fracture completions show discrepancies between the placed propped length and the effective production fracture length. Ineffective fracture clean-up is often cited as a likely culprit. The main results presented in this paper were obtained using a modified conductivity cell to allow polymer concentration via leakoff, and measurements of flow initiation gradients. The paper will discuss the experimental set-up and some of the artifacts that had to be removed prior to ensuring more reliable data. The results highlight the crucial role played by the filter cake and present new data that would significantly change the common industry practice of relying simply on an average polymer concentration factor.1-3 It is shown that contrary to the current method that calculates an average polymer concentration,the polymer,in practice, concentrates only in the filter cake. It is also shown that the filter cake thickness compared to the fracture thickness plays a critical role in creating significant yield stress effects,which could be either avoided through adequate design or used to estimate the resulting productivity loss.
Fabrication technology of and symmetry breaking in superconducting quantum circuits (2009)

Superconducting quantum circuits are promising systems for experiments testing fundamental quantum mechanics on a macroscopic scale and for applications in quantum information processing. We report on the fabrication and characterization of superconducting flux qubits, readout dc SQUIDs, on-chip shunting capacitors, and high-quality coplanar waveguide resonators. Furthermore, we discuss the tunability and fundamental symmetry aspects inherent to all superconducting qubits, which can be regarded as artificial solid-state atoms. Comparing them to their natural counterparts, we discuss first and second-order energy shifts due to static control fields. Additionally, we present an intuitive derivation of the first- and second-order matrix elements for level transitions in the presence of a coherent microwave driving.
The caesium and strontium adsorption properties of bamboo charcoal-containing concrete blocks (2018)

The Fukushima Daiichi Nuclear Power Plant accident was caused by the Great East Japan Earthquake that occurred in March 2011 in Japan. Large amounts of radioactive materials (radioactive caesium, radioactive strontium, radioactive tritium and radioactive iodine.) were released from the power plant into ecosystem components such as air, soil, and water. One way to use bamboo is to produce bamboo charcoal, which is used to purify water and condition soil. Its minerals and adsorption properties are also used for soil conditioning, humidity regulation, water purification, and as electromagnetic shield material. It has also been discovered that bamboo charcoal has a high capacity to adsorb caesium and strontium. The objective of the research described herein was to develop materials that can efficiently recover radioactive substances that exist in water. It is because caesium and strontium are scattered a lot and bamboo is inexpensive, a ubiquitous and harmless material and excellent in adsorption performance. We fabricated concrete blocks mixed with bamboo charcoal and assessed their capacity to adsorb caesium and strontium. Bamboo charcoal and cement were mixed at a 1 : 1 weight ratio and water was added to the mixture. After drying for a day, the hardened mixture was formed into concrete blocks containing bamboo charcoal. Scanning electron microscopy was performed, and factors such as pH and thermal change of the samples were investigated. To study the adsorption capacity of the samples, 1.00 g of the samples was immersed in 100 mL of a 10.0 mg/L caesium solution and strontium solution. After an hour, the concentration of caesium dropped by 40.3% and strontium by 83.1%, indicating that concrete blocks containing bamboo charcoal had a high capacity to adsorb caesium and strontium. Furthermore, the results of thermal analysis showed that the bamboo charcoal-contained in the concrete blocks burned at approximately 400°C. The boiling point of caesium is 670°C and that of strontium is 1381 °C, which suggests that weight can be reduced by burning away the bamboo charcoal at 400°C without the caesium, etc. volatilising. In addition, because the concrete blocks can be formed in various shapes, it holds promise for application in rivers, lakes, sewers.
Pro-Viral and Anti-Viral Roles of the RNA-Binding Protein G3BP1 (2023)

Viruses depend on host cellular resources to replicate. Interaction between viral and host proteins is essential for the pathogens to ward off immune responses as well as for virus propagation within the infected cells. While different viruses employ unique strategies to interact with diverse sets of host proteins, the multifunctional RNA-binding protein G3BP1 is one of the common targets for many viruses. G3BP1 controls several key cellular processes, including mRNA stability, translation, and immune responses. G3BP1 also serves as the central hub for the protein-protein and protein-RNA interactions within a class of biomolecular condensates called stress granules (SGs) during stress conditions, including viral infection. Increasing evidence suggests that viruses utilize distinct strategies to modulate G3BP1 function-either by degradation, sequestration, or redistribution-and control the viral life cycle positively and negatively. In this review, we summarize the pro-viral and anti-viral roles of G3BP1 during infection among different viral families.
Rituximab-induced polymorphic ventricular tachycardia. (2010)

The anti-CD20 monoclonal antibody rituximab is an effective treatment for small lymphocytic lymphoma; however, it has been associated with infusion reactions, including cardiac arrhythmias. Severe cardiac arrhythmia is an adverse reaction that is related to rituximab chemotherapy, and more investigation is warranted into the adverse reactions of rituximab that involve cardiac conduction abnormalities. Herein, we report what we believe to be the 1st case of symptomatic polymorphic ventricular tachycardia to have occurred during an initial infusion of rituximab.
False Lumen Thrombectomy of the Superior Mesenteric Artery Followed by Iliomesenteric Bypass after Stanford Type B Aortic Dissection (2004)

A 55-year-old man with an acute Stanford type B aortic dissection presented with clinical signs of mesenteric ischemia. Computed tomography (CT) revealed a thrombosed false lumen in the superior mesenteric artery. At laparotomy, the dissection was found to be extending into the jejunal branches and medial colic artery. Thrombus was removed from the false lumen, and perfusion was restored with an iliomesenteric bypass, with the dissected layers tacked together in the suture line. A postoperative CT scan showed a stable diameter of the thoracoabdominal aorta and a patent iliomesenteric bypass.
Global stability proofs for continuous-time indirect adaptive control schemes (1987)

This note presents a general stability proof for continuous-time adaptive control, with very general assumptions on the identifier and controller. We show that if the exogenous input signal is rich enough, then both the identifier and the controller converge to their "true" values. Applications of the proof to pole placement design and design based on the factorization approach are discussed.