gebhart/patrepeval huggingface dataset:
Germinal center organization mediated by T-bet dependent expression of CXCR3 and CCR6 (2019)

Abstract The germinal center (GC) is composed of distinct regions with proliferation and affinity maturation of GC B cells (GCB) occurring in the dark zone (DZ) and antigen-mediated selection and commitment of the long-lived plasma cell (LL-PCs) precursors occurring in the light zone (LZ). Despite the key role for GCs in establishing enduring humoral immunity, we know little about the dynamics of the GCB cell response. We showed that the transcription factor T-bet is expressed by GCB cells and that B cell intrinsic T-bet is required for the LL-PC response following influenza (flu) infection. To test whether the loss of LL-PCs in these mice was due to a role for T-bet in regulating the GCB response, we infected 50:50 Tbx21−/−: pepboy chimeric mice with flu and enumerated GCB cells. We found that Tbx21−/− B cells were overrepresented in the GC relative to the pepboy cells and that Tbx21−/− GCB cells were enriched in the LZ. Partitioning of GCB cells in the LZ/DZ is regulated by chemokines and we showed that T-bet controls transcription of two chemokine receptors, CXCR3 and CCR6, which are expressed by GCB cells. Using 50:50 Tbx21−/−: pepboy chimeras, we tested whether T-bet regulates GCB cell positioning by inducing CXCR3 and repressing CCR6. We observed that the CCR6+ GCB cell subset, which is known to localize in the LZ, was very enriched in Tbx21−/− GCB cells. By contrast, the CXCR3+ GCB subset, which was dominated by WT cells, was enriched in the DZ. To determine the role for CXCR3 in GCB cell localization, we infected 50:50 Cxcr3−/− :pepboy chimeras and found that the Cxcr3−/− GCB cells are enriched in the LZ. Therefore, T-bet regulates GCB cell localization and potentially the dynamics of the GC response by controlling CXCR3 and CCR6 expression.
Strengthen the Ideological and Political Education Curriculum in Colleges and Universities in New Era (2021)

世界科学出版社（World Science Publishing-WSP）立足国际，积极配合中国“走出去”出版战略，大力推进版权输出与引进，并不断拓展国际间的交流与合作，取得显著成绩。WSP国际图书出版项目力倡中国科研人员出版英文图书，出版社具有丰富的国际传播资源与雄厚的编辑、翻译、出版力量，拥有一批著名的中外翻译专家、出版专家，及一支精通国际出版的编辑、翻译和国际营销队伍。探索“科学进步”与“社会进步”是人类永恒主题，WSP推崇以科学信仰引领学术方向，遵循各国法律和地方法规，能够协助您优质、快捷、低
Macrosphelide, a Novel Inhibitor of Cell-cell Adhesion Molecule. I. Taxonomy, Fermentation, Isolation and Biological Activities. (1995)

Potent anti-adherent activity was detected in fermentation extracts of microbial strain FO-5050. Active compounds designated macrosphelide A and B were isolated and the structure was determined to be 16-membered macrolide antibiotics possessing three ester bonds in the ring structure. Macrosphelide A dose-dependently inhibited the adhesion of HL-60 cells to LPS-activated HUVEC monolayer (IC50, 3.5 microM); macrophelide B also inhibited HL-60 adhesion but to a lesser extent (IL50, 36 microM). Macrosphelide A did not show any antimicrobial and cytocidal activities at the concentration of 1000 micrograms/ml and 100 micrograms/ml, respectively.
Impact of Modified Albumin–Bilirubin Grade on Survival in Patients With HCC Who Received Lenvatinib: An Analysis Using Time-Dependent ROC (2021)

Abstract We investigated the impact on survival of modified albumin–bilirubin (mALBI) grade vs. Child–Pugh classification in patients with hepatocellular carcinoma (HCC) who received lenvatinib. A total of 524 patients with HCC who received lenvatinib were included. Univariate analysis showed that mALBI grade 2b/3 and Child–Pugh class B/C were significantly associated with survival (hazard ratio [HR], 2.471; 95% confidence interval [CI], 1.944–3.141 and HR, 2.178; 95%CI, 1.591–2.982). In patients with a Child–Pugh score of 5, multivariate analysis showed that mALBI grade 2b/3 was independently associated with survival (HR, 1.814; 95%CI, 1.083–3.037). Conversely, among patients with mALBI grade 1/2a, there was no difference in survival between those with a Child–Pugh class of 5 or 6 (p = 0.735). Time-dependent receiver operating characteristic analysis showed that the ALBI score predicted survival better than the Child–Pugh score. The optimal cut-off value of the ALBI score for predicting survival was nearly the same as the value separating mALBI grades 2a and 2b. In conclusion, the mALBI grade was a better predictor of survival than the Child–Pugh classification in patients with unresectable HCC who received lenvatinib therapy.
Guided-wave second harmonic generation in hexagonally poled RPE:LiNbO/sub 3/ (2006)

In this communication, we report on efficient second harmonic generation (SHG) telecom wavelengths in an optimised buried waveguide made by reverse proton exchange (RPE) in 2D hexagonally poled LiNbO/sub 3/ (HexLN). We also have analysed the response of the HexLN device for the non-symmetric case, in which the two SHG processes, quasi-phase-matched by different reciprocal lattice vectors of the HexLN pattern.
Gender and colorectal cancer (1993)

Studies of gender differences in colorectal cancer have shown temporal shifts in incidence and site distribution which can be attributed, in part, to environmental and behavioural factors. In high-risk populations, rectal cancer and left-sided colon cancer have been more frequent in older men, whereas right-sided colon cancer has been more commonly found in older women. Among known associations with reduced colorectal cancer risk, women appear to ingest more dietary fibre, seem to benefit more from physical activity and body mass, and consume less alcohol. Although these differences may contribute to the risk differential, hormonal events during reproductive years also appear to affect women's risk at older age. The interactions of sex hormone metabolism and nutrition, including dietary fibre, in colorectal carcinogenesis provide a rewarding field for investigation.
Interactive Multi-User 3D Visual Analytics in Augmented Reality (2020)

This publication reports on a research project in which we set out to explore the advantages and disadvantages augmented reality (AR) technology has for visual data analytics. We developed a prototype of an AR data analytics application, which provides users with an interactive 3D interface, hand gesture-based controls and multi-user support for a shared experience, enabling multiple people to collaboratively visualize, analyze and manipulate data with high dimensional features in 3D space. Our software prototype, called DataCube, runs on the Microsoft HoloLens - one of the first true stand-alone AR headsets, through which users can see computer-generated images overlaid onto realworld objects in the user&#x2019;s physical environment. Using hand gestures, the users can select menu options, control the 3D data visualization with various filtering and visualization functions, and freely arrange the various menus and virtual displays in their environment. The shared multi-user experience allows all participating users to see and interact with the virtual environment, changes one user makes will become visible to the other users instantly. As users engage together they are not restricted from observing the physical world simultaneously and therefore they can also see non-verbal cues such as gesturing or facial reactions of other users in the physical environment. The main objective of this research project was to find out if AR interfaces and collaborative analysis can provide an effective solution for data analysis tasks, and our experience with our prototype system confirms this.
Curación de contenidos para periodistas. Conceptos, esquema de trabajo y fuentes abiertas (2020)

Definition proposal for content curation in the context of the professional activity of journalists. Modalities of content curation. Presentation of a basic framework for the development of content curation with phases and tools for searching and monitoring information. Basic bibliography and resources on content curation.
Online Adaptive Learning in Energy Trading Stackelberg Games with Time-Coupling Constraints (2021)

An energy trading mechanism is proposed between a selfish energy broker (aggregator) and her selfish energy customers (prosumers). The proposed design is a Stackelberg game where the aggregator trades energy bidirectionally between the prosumers and the wholesale electricity market for profit. For the purpose of satisfying the prosumers' desired energy consumption, time-coupling constraints are introduced. The described game does not admit closed form equilibrium strategies and therefore an online adaptive learning algorithm is proposed to mitigate this challenge. The latter is scalable with the number of prosumers and does not require explicit knowledge of the prosumers' decision-making mechanisms. Experimental results that utilize real-world data from the California market are provided to demonstrate the performance of the proposed approach.
Protein Folding (1993)

Protein folding has played a major role in both academic and industrial research and development in biotechnology. The biotechnology industry has relied on both in vivo and in vitro protein folding to successfully produce the currently approved therapeutic proteins. In this article, the methods used to produce therapeutic proteins are discussed along with the rationale for choosing an expression system. An industrial perspective of the protein folding problem and potential solutions is provided with an emphasis on the practical aspects of improving in vivo or in vitro folding based on current research. In addition, the future directions of research in protein folding are projected focusing on the potential for improving in vivo folding, predicting protein structure, and ultimately developing new therapeutics.
Visibility Metric for Visually Lossless Image Compression (2019)

Encoding images in a visually lossless manner helps to achieve the best trade-off between image compression performance and quality and so that compression artifacts are invisible to the majority of users. Visually lossless encoding can often be achieved by manually adjusting compression quality parameters of existing lossy compression methods, such as JPEG or WebP. But the required compression quality parameter can also be determined automatically using visibility metrics. However, creating an accurate visibility metric is challenging because of the complexity of the human visual system and the effort needed to collect the required data. In this paper, we investigate how to train an accurate visibility metric for visually lossless compression from a relatively small dataset. Our experiments show that prediction error can be reduced by 40% compared with the state-of-theart, and that our proposed method can save between 25%-75% of storage space compared with the default quality parameter used in commercial software. We demonstrate how the visibility metric can be used for visually lossless image compression and for benchmarking image compression encoders.
Trade-offs in the integration of high performance devices with trench capacitor DRAM (2002)

This paper demonstrates it is possible to enhance the device performance of a standard DRAM process by 35% with only a moderate reduction in retention time. We have also merged high-performance logic devices and working DRAM at the cost of an appreciable degradation in retention behavior and a slightly larger cell. The device performance is 1.82/spl times/ the base process. This demonstrates that embedding DRAM in a high-performance technology is feasible although the optimum trade-off between performance, density, retention time, cost, and power depends on the application.
Les procédures de la Commission (2017)

In this course, José Antonio Pastor Ridruejo examines the interplay of politics and law in the special public procedures initiated by the United Natio…
454: Malignant Hyperthermia-Like Syndrome in a Pediatric Female With Hyperosmolar Hyperglycemic State (2020)

Barry, Dana1; Helmond, Jennifer van2; Kauffmann, Travis3; Levenbrown, Yosef3; Theroux, Mary4 Author Information
Supplementary Figure from (+)-JJ-74–138 is a Novel Noncompetitive Androgen Receptor Antagonist (2023)

Supplementary Figure from (+)-JJ-74–138 is a Novel Noncompetitive Androgen Receptor Antagonist
Aortic dissection in a cardiac allograft recipient: a case report. (1996)

Ascending aortic dissection is rare in cardiac allograft recipients. Only two patients with dissection arising from the native aorta have been reported previously and, unfortunately, the diagnosis was made postmortem in each instance. We report the first case of successful surgical treatment of aortic dissection confined to the donor aorta in a recipient of an orthotopic cardiac allograft.
Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins (1993)

Many GTP-binding proteins (GBPs) are modified by mevalonic acid (MVA)-dependent isoprenylation, carboxyl methylation or palmitoylation. The effects of inhibitors of these processes on insulin release were studied. Intact pancreatic islets were shown to synthesize and metabolize MVA and to prenylate several candidate proteins. Culture with lovastatin (to inhibit synthesis of endogenous MVA) caused the accumulation in the cytosol of low-M(r) GBPs (labelled by the [alpha-32P]GTP overlay technique), suggesting a disturbance of membrane association. Concomitantly, lovastatin pretreatment reduced glucose-induced insulin release by about 50%; co-provision of 100-200 microM MVA totally prevented this effect. Perillic acid, a purported inhibitor of the prenylation of small GBPs, also markedly reduced glucose-induced insulin secretion. Furthermore, both N-acetyl-S-trans,trans-farnesyl-L-cysteine (AFC), which inhibited the base-labile carboxyl methylation of GBPs in islets or in transformed beta-cells, and cerulenic acid, an inhibitor of protein palmitoylation, also reduced nutrient-induced secretion; an inactive analogue of AFC (which did not inhibit carboxyl methylation in islets) had no effect on secretion. In contrast with nutrients, the effects of agonists that induce secretion by directly activating distal components in signal transduction (such as a phorbol ester or mastoparan) were either unaffected or enhanced by lovastatin or AFC. These data are compatible with the hypothesis that post-translational modifications are required for one or more stimulatory GBPs to promote proximal step(s) in fuel-induced insulin secretion, whereas one or more inhibitory GBPs might reduce secretion at a more distal locus.
Preparation of Pure DyBa2Cu3O7-X Nanocluster Superconductors Using Biopolymer Chitosan (2012)

We used sol-gel method for synthesizing nanoclusters of DyBa2Cu3O7-X high TC type II su-perconductor in presence of biopolymer chitosan. In the first stage, the precursor and biopoly-mer aggregated into amorphous matrix and hydrogels are then formed by thermogelling. The fibrous nature of the biopolymer chitosan is retained at high temperatures up to 500 °C. After heating to 900 °C, complete decomposition of BaCO3 and formation of the superconductor na-noparticles (with a diameter of 10-20 nm) occurred subsequently. Characterization of speci-mens was performed using scanning electron microscopy and transmission electron microscopy, supported by other techniques including XRD diffraction, energy dispersive X-ray, FT-IR spectrum and magnetic susceptibility measurements.
Fatal hemorrhagic pneumonia: Don’t forget Stenotrophomonas maltophilia (2016)

We present a case of fatal hemorrhagic pneumonia secondary to Stenotrophomonas maltophilia in a patient with acute myeloid leukemia. S. maltophilia is commonly a non-virulent pathogen. However, in the immunocompromised, it is generally associated with bacteremia after central venous catheter placement or pneumonia. Hemorrhagic pneumonia is a rare presentation of this bacteria, with only 31 cases reported in the literature, and has 100% mortality within 72 hours. Rapid recognition and early suspicion should be key in the treatment of these patients.
Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages (2013)

Studies of macrophage biology have been significantly advanced by the availability of cell lines such as RAW264.7 cells. However, it is unclear how these cell lines differ from primary macrophages such as thioglycolate-elicited peritoneal macrophages (TGEMs). We used the inflammatory stimulus Kdo2-lipid A (KLA) to stimulate RAW264.7 and TGEM cells. Temporal changes of lipid and gene expression levels were concomitantly measured and a systems-level analysis was performed on the fold-change data. Here we present a comprehensive comparison between the two cell types. Upon KLA treatment, both RAW264.7 and TGEM cells show a strong inflammatory response. TGEM (primary) cells show a more rapid and intense inflammatory response relative to RAW264.7 cells. DNA levels (fold-change relative to control) are reduced in RAW264.7 cells, correlating with greater downregulation of cell cycle genes. The transcriptional response suggests that the cholesterol de novo synthesis increases considerably in RAW264.7 cells, but 25-hydroxycholesterol increases considerably in TGEM cells. Overall, while RAW264.7 cells behave similarly to TGEM cells in some ways and can be used as a good model for inflammation- and immune function-related kinetic studies, they behave differently than TGEM cells in other aspects of lipid metabolism and phenotypes used as models for various disorders such as atherosclerosis.
An aqueous pathway to polymeric foaming with nanoclay (2012)

The property of osmotic swelling of a hectorite clay suspension in water is exploited for dispersing it in a polymeric foam matrix. This green route eludes the surface modification of clay as well as the mediation by organic solvents for clay dispersion during foaming. The route follows the initial swelling and partial delamination of clay galleries by water molecules, followed by further dispersion in an oligomeric isocyanate foaming component, before conducting reactive foaming. A nominal mass fraction of clay provides an effective barrier, restricting the gas phase mass transport in the foam. Electron microscopic investigations show that clay particles are preferentially located on the lamellar part of the microscopic foam cell, rather than on plateau borders.
Creating a MEDPAR (Medicare provider analysis and review) analog to the RUG-III (Resource Utilization Groups, Version III) classification system. (1994)

As Medicare payments for post-acute institutional care continue to rise sharply, policy interest in the clinical characteristics of beneficiaries admitted to nursing homes and their variation across facilities has stimulated research into case mix. Measures of Medicare skilled nursing facility (SNF) case mix are important in relating payments to the care requirements of residents. The Resource Utilization Groups, Version III (RUG-III) classification system uses a new minimum data set that is not currently available nationally. In preparation for a multi-State demonstration, we needed to simulate at least the first-level splits at the national, State, and facility level. Therefore, we developed proxy measures using comparable data available on the National Claims History files. The analog is an easily programmed measure of the acuity/severity of beneficiaries' conditions across a Medicare Part A SNF stay in 75 percent of the SNF providers. This can be a method for estimating changes in case mix over the years, and differences across provider types and States.
Anticonvulsive activity of indenoimidazolidinones and related heterocyclic compounds in mice. (1980)

A series of substituted cyclic ureides and related compounds, one of them a thio analog, were synthesized by condensing ninhydrin with urea, thiourea, dimethylurea or other aromatic or bifunctional agents. When tested against seizures induced in mice by the chemoconvulsant Metrazol or against audiogenic seizures, four compounds decreased either the incidence or the severity of convulsive manifestations and protected from mortality in seizures. The effective compounds were not toxic at the administered level (150 mg/kg) and produced few observable sedative effects.
Stimulus-dependent Phosphorylation of G-protein-coupled Receptors by Casein Kinase 1α (1997)

We have previously demonstrated that the phospholipase C-coupled m3-muscarinic receptor is phosphorylated in an agonist-sensitive manner by a protein kinase of approximately 40 kDa purified from porcine cerebellum (Tobin, A. B., Keys, B., and Nahorski, S. R. (1996) J. Biol Chem. 271, 3907-3916). This kinase, called muscarinic receptor kinase (MRK), is distinct from second messenger-regulated protein kinases and from beta-adrenergic receptor kinase and other members of the G-protein-coupled receptor kinase family. In the present study we propose that MRK is casein kinase 1alpha (CK1alpha) based on the following evidence: 1) the amino acid sequence from two proteolytic peptide fragments derived from purified MRK corresponded exactly to sequences within CK1alpha. 2) Casein kinase activity co-eluted with MRK activity from the final two chromatography steps in the purification of porcine brain MRK. 3) Recombinant CK1alpha expressed in Sf9 cells is able to phosphorylate both casein and the bacterial fusion protein, Ex-m3, that contains a portion of the third intracellular loop of the m3-muscarinic receptor downstream of glutathione S-transferase. 4) Partially purified CK1alpha increased the level of muscarinic receptor phosphorylation in an agonist-sensitive manner when reconstituted with membranes from Chinese hamster ovary-m3 cells expressing the human recombinant m3-muscarinic receptor. 5) Partially-purified CK1alpha phosphorylated rhodopsin, contained in urea-treated bovine rod outer segment membranes, and the extent of phosphorylation was increased in the presence of light. These data demonstrate that the kinase previously called MRK is CK1alpha, and that CK1alpha offers an alternative protein kinase pathway from that of the G-protein-coupled receptor kinase family for the stimulus-dependent phosphorylation of the m3-muscarinic receptor, rhodopsin, and possibly other G-protein-coupled receptors.
Multiple Bragg scattering in decagonal quasicrystals (1996)

The purpose of this research is to perform a comparative study upon closely-related quasicrystalline materials. Three decagonal quasicrystals of compositions $Al\sb{68}Cu\sb{11}Co\sb{21},\ Al\sb{71}Ni\sb{24}Fe\sb5,$ and $Al\sb{72.5}Ni\sb{16.5}Co\sb{11}$ are studied using x-ray diffraction techniques. Multiple Bragg Scattering studies reveal that none of the samples is centrosymmetric. X-ray precession photography and Multiple Bragg Scattering together provide qualitative insights into the similarities and differences between the three compositions. In particular, the intensities, locations, and appearances of the Multiple Bragg Scattering peaks reveal features of the $Al\sb{68}Cu\sb{11}Co\sb{21}$ system that are not present in the other two systems.
Surface-bound TGF-beta1 on effusion-derived exosomes participates in maintenance of number and suppressive function of regulatory T-cells in malignant effusions. (2010)

Elimination of Eff-Ex or control of Eff-Ex expressing TGF-β1 may be new therapeutic strategies in immunotherapy for advanced cancer patients with malignant effusions.