gebhart/patrepeval huggingface dataset:
Interactions between piperonyl butoxide analogues and metabolic enzymes conferring insecticide resistance (2010)

The insecticide synergist, piperonyl butoxide (PBO), has been used to reduce resistance factors and to characterise metabolic resistance resulting from mixed function oxidases (MFOs). Studies have also shown that PBO can interact with resistance-associated esterases. It is well-documented that the mechanism by which PBO inhibits P450s is the interaction of the methylenedioxyphenyl (MDP) moiety of PBO molecule with the haem moiety of the enzyme. To investigate the interactions between PBO and esterases, a structure activity relationship (SAR) study was carried out using analogues of PBO and E4, a resistanceassociated esterase from the peach-potato aphid Myzus persicae. Results indicate that the polyether and the alkyl chain were fundamentally important in this interaction. Removing one oxygen atom from the MDP moiety of PBO did not affect the binding affinity, but increased affinities resulted from the replacement of the polyether with an alkynyl ether chain or by increasing the length of the alkyl chain. An analogue, EN 16/5-1, that retains the ability to interact with esterases but loses the ability to act on P450s, due to a modification to the MDP moiety, was used in conjunction with PBO to facilitate characterisation of metabolic resistance in M. persicae and pollen beetle Meligethes aeneus. Selected analogues of PBO containing the alkynyl ether side chain exhibited high synergistic effects in vivo and were found to be potent inhibitors of O-deethylation of 7-ethoxycoumarin when tested against pyrethroid resistant M. aeneus. The capability of some of the analogues to act as insecticide synergists was investigated in vivo against two M. persicae clones possessing different metabolic resistance profiles. Finally, the potential of PBO analogues to provide potent and/or specific synergism to overcome insecticide resistance and reduce insecticide titre applied to crops is considered.
Oxygen sensors in hypoxic pulmonary vasoconstriction (2006)

Hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism adapting lung perfusion to regional ventilation. Perturbations to HPV, such as those occurring in pneumonia, acute respiratory distress syndrome and liver failure, can result in arterial hypoxemia. Under conditions of general hypoxia, HPV increases pulmonary vascular resistance and thus causes acute pulmonary hypertension. Despite intensive research, the underlying mechanisms of HPV have not been fully elucidated. Deciphering signalling pathways that result in HPV could suggest novel approaches to address a failure of HPV, as well as for the treatment of pulmonary hypertension associated with HPV. Within this context, this review focuses on current concepts in the oxygen sensing mechanisms that underlie HPV.
Osmolarity: A hidden factor in Nanotoxicology (2016)

In the field of drug delivery, long circulating nanocarriers in the blood have many advantages such as targeted drug delivery and sustained release. Based on our current knowledge, evaluation of the effect of long circulating nanocarriers in the blood stream on osmolarity of plasma has not been reported before. In this study, osmotic pressure developed by some commercially available nanocarriers was estimated based on Van't Hoff equation. It is noteworthy that theoretically, nanocarriers do not have any significant effect on osmolarity of plasma. However, it is worth being evaluated experimentally in order to be taken into account in future studies.
A Non-Gastrin Secretogogue in Ulcerogenic Tumors of the Pancreas (1984)

In 18 patients with hypersecretion of acid, severe ulcer diathesis, and pancreatic islet cell tumor or hyperplasia, 14 had hypergastrinemia and 4 had normal plasma gastrin concentration. The neoplasms contained several gut peptides beside gastrin. The immunoreactive gastrin in the tumor extracts measured less than 7 ng/g, less than the amount previously reported. The extracts of each patient's tumor also contained a secretogogue other than gastrin that stimulated gastric acid secretion in rats. In addition, the plasma extracts of 2 patients also contained a secretogogue that stimulated acid secretion. After surgical resection of a recurrent metastatic tumor in 1 patient, basal acid secretion decreased from 13.9 to less than 1 meq/h, and the bioactivity of the plasma disappeared. These observations suggest the existence of a secretogogue that appears to be a protein in the pancreatic tumors of some patients with severe ulcer diathesis and hypersecretion.
Group A Streptococcal Puerperal Sepsis with Retroperitoneal Involvement Developing in a Late Postpartum Woman: Case Report (2004)

Group A beta-hemolytic streptococci cause a wide range of infectious diseases such as pharyngitis, impetigo, rheumatic fever, and even septic shock. Group A streptococcal puerperal sepsis is uncommon today, but recent reports indicate a reemergence of virulent strains can cause toxic-mediated shock and multiple organ failure. We present a case report of a 29-year-old postpartum woman after cesarean section who presented group A streptococcal puerperal sepsis. Furthermore, we discuss the GAS strain in this patient and its relation with close contact among family members. The group A streptococci (GAS) were isolated from the patient's retroperitoneal fluid and from her husband's throat swab, respectively. Both isolates were shown to be identical: M type 1. It is well known that exotoxin A produced by M1 or M3 serotypes of the organisms plays a crucial role in streptococcal toxic shock syndrome (STSS). We conclude that in this patient, close contacts of persons with GAS appear to be at risk for colonization with identical strains of STSS-causing GAS such as M1 or M3 serotypes. Therefore, the appropriate antibiotic including antibiotic prophylaxis for close contact should be considered.
Insights into Dehydrogenative Coupling of Alcohols and Amines Catalyzed by a (PNN)–Ru(II) Hydride Complex: Unusual Metal–Ligand Cooperation (2011)

Density functional theory calculations were performed to elucidate the mechanism of dehydrogenative coupling of primary alcohols and amines mediated by a PNN-Ru(II) hydride complex (PNN = (2-(di-tert-butylphosphinomethyl)-6-(diethylaminomethyl)pyridine)). A plausible reaction pathway was proposed which contains three stages: (1) The alcohol dehydrogenation reaction to generate the aldehyde and H(2); (2) The aldehyde-amine condensation reaction to form the hemiaminal intermediate; (3) The dehydrogenation process of the hemiaminal intermediate to yield the final amide product with the liberation of H(2). The first and third stages occur via a similar pathway: (a) Proton transfer from the substrate to the PNN ligand; (b) Intramolecular rearrangement of the deprotonated substrate to form an anagostic complex; (c) Hydride transfer from the deprotonated substrate to the Ru center to yield the trans-dihydride intermediate and the aldehyde (or amide); (d) Benzylic proton migration from the PNN ligand to the metal center forming a dihydrogen complex and subsequent H(2) liberation to regenerate the catalyst. In all these steps, the metal-ligand cooperation plays an essential role. In proton transfer steps (a) and (d), the metal-ligand cooperation is achieved through the aromatization/dearomatization processes of the PNN ligand. While in steps (b) and (c), their collaboration are demonstrated by the formation of an anagostic interaction between Ru and the C-H bond and two ionic hydrogen bonds supported by the PNN ligand.
GTPase domains of ras p21 oncogene protein and elongation factor Tu: Analysis of three-dimensional structures, sequence families, and functional sites (guanine nucleotide binding/structure comparison/multiple sequence alignment/contact analysis/exchange factor) (2016)

GTPase domains are functional and struc- tural units employed as molecular switches in a variety of important cellular functions, such as growth control, protein biosynthesis, and membrane traffic. Amino acid sequences of more than 100 members of different subfamilies are known, but crystal structures of only mammalian ras p21 and bacterial elongation factor Tu have been determined. After optimal superposition of these remarkably similar structures, careful multiple sequence alignment, and calculation of residue- residue interactions, we analyzed the two subfamilies in terms of structural conservation, sequence conservation, and residue contact strength. There are three main results. (i) A structure- based alignment of p21 and elongation factor Tu. (it) The dermition of a common conserved structural core that may be useful as the basis of model building by homology of the three-dimensional structure of any GTPase domain. (iii) Iden- tification of sequence regions, other than the effector loop and the nucleotide binding site, that may be involved in the functional cycle: they are loop L4, known to change confor- mation after GTP hydrolysis; helix a2, especially Arg-73 and Met-67 in ras p21; loops L8 and L10, including ras p21 Arg-123, Lys-147, and Leu-120; and residues located spatially near the N and C termini. These regions are candidate sites for
Gender schema and fashion consciousness (1989)

Abstract Psychologists, consumer researchers, and marketers have long measured psychological traits related to gender, especially gender schema. This study assesses various psychological gender measures, including a new one, gender consciousness, in relation to a marketing variable of interest, fashion consciousness. Results indicate that biological sex is predominant when assessing the two sexes together. However, other variables emerge as important when within‐sex differences are assessed: public self‐consciousness for females and private gender consciousness (a new measure) for males. Marketing implications are discussed, primarily on the basis of these within‐sex differences, since fashion marketers usually target separately one or the other sex in their campaigns.
On the metric properties of discrete space-filling curves (1996)

A space-filling curve is a linear traversal of a discrete finite multidimensional space. In order for this traversal to be useful in many applications, the curve should preserve "locality". We quantify "locality" and bound the locality of multidimensional space-filling curves. Classic Hilbert space-filling curves come close to achieving optimal locality.
[The predictive value of parathyroid hormone levels and decreases for postoperative hypocalcemia after total thyroidectomy]. (2017)

<b>Objective:</b>To investigate the predictive value of parathyroid hormone levels and decreases for postoperative hypocalcemia after total thyroidectomy. <b>Method:</b>We reviewed 71 consecutive patients who underwent total thyroidectomy, measured postoperative hypocalcemia, parathyroid hormone (PTH) values within 24 hours after surgery, divided them into subgroups accroding to hypocalcemia symptom. Combining with postoperative serum calcium，postoperative PTH values and decreases (△PTH), we used the receiver operating characteristic curve (ROC) analysis to assessment of predictive value. <b>Result:</b>The mean value of postoperative serum calcium, postoperative PTH and △PTH between subgroups have a significant difference (<i>P</i><0.01). ROC area under the curve (AUC) of △PTH is 0.9706, with cutoff value 0.7366. AUC of postoperative PTH is 0.9580, with cutoff value 14.82 ng/L. <b>Conclusion:</b>The postoperative PTH and △PTH is a reliable indicator to judging postoperative hypocalcemia after total thyroidectomy.
Renale Sympathikusdenervation bei arterieller Hypertonie - Pro (2012)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Residential Heating Using Woody Biomass in Germany—Supply, Demand, and Spatial Implications (2022)

Low-carbon energy requires more land than the non-renewable resources. This paper balances holistic assessments of the land demands for biomass heating and their ecosystem services. It is predicted that biomass will continue to play an important role in the heating sector in Germany by 2050, as it is one way to increase the use of renewable energy and reduce CO2 emissions. To balance this out, it is important to ensure that the substitution of fossil fuels with fuelwood does not result in losses in biodiversity, natural forest, and agricultural land. Based on the observed types of fuel demand, the need for space in terms of the growing area is characterized as the corresponding land under the consideration of a given land-use type. Formulas have been applied at the federal level in Germany. The area required to supply an average German household is 0.64 ha if all the wood harvested is used for energy purposes, but this is in competition with all other types of timber use. Fuelwood from thinning alone cannot meet the domestic demand. However, a sustainable supply of woody biomass is possible if residues mainly from forestry and the wood processing industry are used, causing a land demand of 2.69 ha per house, possibly in combination with smaller shares of the above-mentioned types of use. Thus, the shares of pellets and wood chips for heating purposes should be expanded, which would also bring ecological advantages. The qualitative consideration of forest ecosystem services shows that changing the forest composition or management may increase the fuelwood supply but does not necessarily decrease forest ecological services.
Improving Bayesian Population Dynamics Inference: A Coalescent-Based Model for Multiple Loci (2012)

Effective population size is fundamental in population genetics and characterizes genetic diversity. To infer past population dynamics from molecular sequence data, coalescent-based models have been developed for Bayesian nonparametric estimation of effective population size over time. Among the most successful is a Gaussian Markov random field (GMRF) model for a single gene locus. Here, we present a generalization of the GMRF model that allows for the analysis of multilocus sequence data. Using simulated data, we demonstrate the improved performance of our method to recover true population trajectories and the time to the most recent common ancestor (TMRCA). We analyze a multilocus alignment of HIV-1 CRF02_AG gene sequences sampled from Cameroon. Our results are consistent with HIV prevalence data and uncover some aspects of the population history that go undetected in Bayesian parametric estimation. Finally, we recover an older and more reconcilable TMRCA for a classic ancient DNA data set.
Effects of spatial audio on memory, comprehension, and preference during desktop conferences (2001)

An experiment was conducted to determine the effect of spatial audio on memory, focal assurance, perceived comprehension and listener preferences during desktop conferences. Nineteen participants listened to six, pre-recorded, desktop conferences. Each conference was presented using either non-spatial audio, co-located spatial audio, or scaled spatial audio, and during half of the conferences, static visual representations of the conferees were present. In the co-located condition, each conferees voice originated from directly above their image on the screen, and in the scaled spatial audio condition, the spatial separation between conferee voices was increased beyond the visual separation. Results showed that spatial audio improved all measures, increasing memory, focal assurance, and perceived comprehension. In addition, participants preferred spatial audio to non-spatial audio. No strong differences were found in the visual conditions, or between the co-located spatial condition and the scaled spatial conditions.
Corrigenda (1980)

W. R. Jackson, A. Stragalinou, J. U. G. Strauss, R. S. Norton, R. P. Gregson and R. J. Quinn, J. Chem. Soc., Chem. Commun., 1980, 680 DOI: 10.1039/C39800000680
Nitrogen extrusion from the bis-azoalkane [anti(syn)]-7,7'-bi-2,3-diazabicyclo[2.2.1]hept-2-ene (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitrogen extrusion from the bis-azoalkane [anti(syn)]-7,7'-bi-2,3-diazabicyclo[2.2.1]hept-2-eneWaldemar Adam, Klaus Hannemann, R. Marshall Wilson, Eva Maria Peters, Karl Peters, and Hans Georg Von SchneringCite this: J. Am. Chem. Soc. 1987, 109, 17, 5250–5260Publication Date (Print):August 1, 1987Publication History Published online1 May 2002Published inissue 1 August 1987https://pubs.acs.org/doi/10.1021/ja00251a033https://doi.org/10.1021/ja00251a033research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Studies on the Antitumor Activity, Mechanism of Action, and Cell Cycle Effects of Camptothecin (1971)

Camptothecin was active in increasing survival time in mice bearing various experimental leukemias. In addition, it produced 70–90% long-term survivors in mice bearing leukemias L5178Y or K1964. It was also active against the plasma cell tumor YPC-1 but less effective against a mast cell tumor and a reticulum cell sarcoma. The alkaloid was also cytotoxic in vitro against three cell lines. Studies using human lymphocytes stimulated by phytohemagglutinin (PHA) indicated that DNA synthesis was strongly inhibited with concentrations of the drug that did not affect RNA or protein synthesis. Camptothecin not only inhibited DNA synthesis but also caused a G2 “lesion” which prevented subsequent mitosis. It did not have cytocidal effects on resting “G0” lymphocytes. However, when “G0” lymphocytes exposed to the alkaloid were subsequently stimulated to enter cycle, their division was still blocked. These observations not only imply that eventual cell proliferation is necessary for the antitumor activity of camptothecin, but also suggest that the drug may be useful for tumors with long G1 intervals.
Data Sharing Environment (1992)

This chapter contains sections titled: System Architecture, Buffer Management Policy, Transaction Execution, Simulation Model
Control systems for induction machines with magnetic saturation (1996)

Extensions of field-oriented control methods for induction machines, accounting for magnetic saturation, are developed. The new methods are based on a nonlinear /spl pi/ model for the saturated machine. This model is a more accurate representation of the saturation phenomena in the machine than are most previous models, and it is shown to also facilitate development of control algorithms. Observers for estimating rotor flux are also discussed. Experimental results verifying operation of one proposed control method are presented.
High-voltage low power analogue-to-digital conversion for adaptive architectures of capacitive vibration energy harvesters (2010)

International audience
Densitat i contingut de nutrients de les branques de faig durant el procés de descomposició (1989)

catalaA partir de branques de faig datades, procedents de tales, s'ha mesurat la densitat i els continguts de nutrients de la fusta al llarg del proces de descomposicio. Hi ha una disminucio continuada de la densitat, amb una major perdua de pes a partir dels 9 anys. Les concentracions de P, K i Mg disminueixen al llarg del proces, mentre que augmenten les de N i Ca. Tanmateix, el contingut de tots els nutrients es menor a la fusta de 12 anys que a la fusta sense descompondre. EnglishWood density and nutrient contents have been measured in beech branches at different decay states, from dated thinnings. Wood density declined continuously, with a greater weight loss from 9 till 12 years since cutting. Concentrations of P, K and Mg declined during the process, but N and Ca increased. Nevertheless, absolute contents at 12 years were lesser than initial ones, for all nutrients.
The Cleveland Clinic FACES Score (2009)

In lieu of limited resources, our multidisciplinary face transplant team requires a preliminary, supplemental objective grading scheme for identifying the optimal face transplant candidate. Therefore, our objective was to develop an effective method for evaluating "facial deficit," which could also be used in the future for the allocation of limited facial organs, analogous to liver transplantation.Each candidate is screened using our institutional review board-approved protocol's current inclusion/exclusion criteria. Five categories were conceptualized to be of significance in evaluating patients in pursuit of facial allotransplantation as per our recent experience, as determined by the face transplant team. All patients with unfavorable characteristics such as evidence of poor medical compliance, an unsatisfactory psychosocial evaluation by our team's transplant psychiatrist, and/or end-stage organ disease suggestive of significant comorbidity were excluded.This study resulted in a reproducible scoring system allowing our team the unprecedented ability to stratify facial deficit in a standardized fashion. The FACES scores ranged from 10 (minimum) to 60 (maximum). Besides being used as a supplemental prescreening and/or postscreening tool, the FACES score has also provided an unprecedented framework for establishing a face transplant candidate registry within our institution, with the optimal recipients receiving the highest of scores.This FACES score objectively stratifies face transplant candidates for their facial deficit during multiple steps throughout the screening process and affords our institution the means of creating a registry. If substantiated, this supplemental score may ultimately predict successful outcomes, determine optimal utility, and provide insight toward prognosis with respect to facial composite tissue allotransplantation.
Vascular Neurologists as Directors of Stroke Centers in the United States (2015)

Vascular neurologist led about one-third of stroke centers. There is opportunity for vascular neurologists to increase their role in stroke center directorship.
Reliability and performance of 808-nm single emitter multi-mode laser diodes (2010)

Performance, lifetest data, as well as failure modes from two different device structures will be discussed in this paper, with emitting wavelengths from 780nm to 800nm. The first structure, designed for high temperature operation, has demonstrated good reliability on various packages with output power up to 10W from a 200&mu;m emitting area. The device structure can be operated up to 60&deg;C heatsink temperatures under CW conditions. Then a high efficiency structure is shown with further improvement on operation power and reliability, for room temperature operation. With ongoing lifetest at 12A and 50&deg;C heatsink temperature, &lt;1000 FIT has been achieved for 6.5W and 33&deg;C operation, on both designs. MTT10%F at 10W and 25&deg;C operation is estimated to be more than 20,000 hours. Devices retain more than 20W rollover power under CW conditions, when re-tested after several thousand hours of accelerated lifetest. Paths for reliability improvement will also be discussed based on observed lifetest failure modes from these two structures.