gebhart/patrepeval huggingface dataset:
Systematic analysis of three FHM genes in 39 sporadic patients with hemiplegic migraine (2007)

We show that FHM genes are involved in at least a proportion of SHM patients without associated neurologic symptoms. Screening of ATP1A2 offers the highest likelihood of success. Because FHM gene mutations were also found in family members with "nonhemiplegic" typical migraine with and without aura, our findings reinforce the hypothesis that FHM, SHM, and "normal" migraine are part of a disease spectrum with shared pathogenetic mechanisms.
Biodegradability of Cellulose Acetate Plasticized with Citrate Esters (1996)

Abstract Cellulose acetate (CA) was melt compounded with two different citric acid esters: triethyl citrate and acetyl triethyl citrate. It was observed, based on the glass transition temperatures, that both plasticizers were miscible with CA. The addition of plasticizer reduced the tensile modulus and increased the elongation of CA. The biodegradation rates increased dramatically with an increase in plasticizer content.
Chronic active hepatitis in Jerusalem: comparison between HBsAg-negative and HBsAg-positive cases. (1978)

Molecular-dynamics (MD) simulations have been performed for two amorphous polymers with extremely different mechanical properties, atactic polystyrene (PS) and bisphenol A polycarbonate (PC), in the isotropic state and under load. The glass transition temperatures, Young moduli, yield stresses and strain-hardening moduli are calculated and compared to the experimental data. Both chemistry-specific and mode-coupling aspects of the segmental mobility in the isotropic case and under the uniaxial deformation have been identified. The mobility of the PS segments in the deformation direction is increased drastically beyond the yield point. A weaker increase is observed for PC.
Microdischarges with plane cathodes (1999)

By reducing the dimensions of the electrodes to the submillimeter range, it is possible to operate dc gas discharges at pressures up to 760 Torr (argon). A plane geometry for the cathode, different from the well-known microhollow cathode discharge, was used in these experiments. For anode hole diameters smaller than 0.6 mm and pD (D diameter of the anode hole) larger than 9 Torr cm, the differential resistivity in the I–V characteristics is similar to the hollow cathode one. The emission in the visible range is distributed more homogeneously over the entire cathode surface. By using a end-on coupled configuration of hollow and plane cathode geometries, the discharge can be stabilized over the entire (pD) range between 1 and 23 Torr cm. The discharge is stable, for both the hollow–plane and hollow–hollow cathode configurations in aligned geometries.
The human visual cortex responds to gene therapy–mediated recovery of retinal function (2011)

Leber congenital amaurosis (LCA) is a rare degenerative eye disease, linked to mutations in at least 14 genes. A recent gene therapy trial in patients with LCA2, who have mutations in RPE65, demonstrated that subretinal injection of an adeno-associated virus (AAV) carrying the normal cDNA of that gene (AAV2-hRPE65v2) could markedly improve vision. However, it remains unclear how the visual cortex responds to recovery of retinal function after prolonged sensory deprivation. Here, 3 of the gene therapy trial subjects, treated at ages 8, 9, and 35 years, underwent functional MRI within 2 years of unilateral injection of AAV2-hRPE65v2. All subjects showed increased cortical activation in response to high- and medium-contrast stimuli after exposure to the treated compared with the untreated eye. Furthermore, we observed a correlation between the visual field maps and the distribution of cortical activations for the treated eyes. These data suggest that despite severe and long-term visual impairment, treated LCA2 patients have intact and responsive visual pathways. In addition, these data suggest that gene therapy resulted in not only sustained and improved visual ability, but also enhanced contrast sensitivity.
Association of ABO blood groups and vitiligo. (1977)

ABO blood group frequencies of 1000 vitiligo patients were studied and compared with those of blood donors and local population. The relative risk of O was significantly reduced in patients in comparison with blood donors but not with local population. This can possibly be explained by the well-known preference of O group donors in the blood bank. On a review of other studies it was felt that there may not be any real association of ABO blood groups with vitiligo.
Interaction Design for Mobile Visual Search (2013)

Mobile devices are becoming ubiquitous. People take pictures via their phone cameras to explore the world on the go. In many cases, they are concerned with the picture-related information. Understanding user intent conveyed by those pictures therefore becomes important. Existing mobile applications employ visual search to connect the captured picture with the physical world. However, they only achieve limited success due to the ambiguity nature of user intent in the picture-one picture usually contains multiple objects. By taking advantage of multitouch interactions on mobile devices, this paper presents a prototype of interactive mobile visual search, named TapTell, to help users formulate their visual intent more conveniently. This kind of search leverages limited yet natural user interactions on the phone to achieve more effective visual search while maintaining a satisfying user experience. We make three contributions in this work. First, we conduct a focus study on the usage patterns and concerned factors for mobile visual search, which in turn leads to the interactive design of expressing visual intent by gesture. Second, we introduce four modes of gesture-based interactions (crop, line, lasso, and tap) and develop a mobile prototype. Third, we perform an in-depth usability evaluation on these different modes, which demonstrates the advantage of interactions and shows that lasso is the most natural and effective interaction mode. We show that TapTell provides a natural user experience to use phone camera and gesture to explore the world. Based on the observation and conclusion, we also suggest some design principles for interactive mobile visual search in the future.
Delivery of Drugs with Ultrasound (2001)

In this article we discuss the potential role of microbubbles, traditionally used as ultrasound contrast agents, for site-specific drug delivery. To reach this goal, microbubbles capable of carrying a drug payload are being developed. To ensure that these microbubbles reach sufficient local concentration at disease sites, specific targeting for diseased tissues can be accomplished using several strategies. These strategies rely on either the intrinsic properties of microbubble shells or conjugation of monoclonal antibodies or other ligands to these shells that recognize antigens expressed in regions of disease. Site-specific delivery of antiinflammatory, antineoplastic, and thrombolytic drugs with microbubbles can be further enhanced by the ability to locally destroy microbubbles within an acoustic field, thereby releasing drugs and improving drug efficacy without systemic adverse effects. In the case of thrombi, ultrasound-mediated microbubble destruction also may facilitate the process of clot lysis. This review also will consider current limitations and technological advances required for the development of this field.
Safety and Efficacy of Growing Rod Technique for Pediatric Congenital Spinal Deformities (2011)

Level IV, case series.
Butane-1,4-diol from Hydrolytic Reduction of Furan (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTButane-1,4-diol from Hydrolytic Reduction of FuranJames M. WatsonCite this: Ind. Eng. Chem. Prod. Res. Dev. 1973, 12, 4, 310–311Publication Date (Print):December 1, 1973Publication History Published online1 May 2002Published inissue 1 December 1973https://pubs.acs.org/doi/10.1021/i360048a009https://doi.org/10.1021/i360048a009research-articleACS PublicationsRequest reuse permissionsArticle Views278Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Finite-state code generation (1999)

This paper describes GBURG, which generates tiny, fast code generators based on finite-state machine pattern matching. The code generators translate postfix intermediate code into machine instructions in one pass (except, of course, for backpatching addresses). A stack-based virtual machine---known as the Lean Virtual Machine (LVM)---tuned for fast code generation is also described. GBURG translates the two-page LVM-to-x86 specification into a code generator that fits entirely in an 8 KB I-cache and that emits x86 code at 3.6 MB/set on a 266-MHz P6. Our just-in-time code generator translates and executes small benchmarks at speeds within a factor of two of executables derived from the conventional compile-time code generator on which it is based.
On-board image-based vehicle detection and tracking (2009)

In this paper we present a computer vision system for daytime vehicle detection and localization, an essential step in the development of several types of advanced driver assistance systems. It has a reduced processing time and high accuracy thanks to the combination of vehicle detection with lane-markings estimation and temporal tracking of both vehicles and lane markings. Concerning vehicle detection, our main contribution is a frame scanning process that inspects images according to the geometry of image formation, and with an Adaboost-based detector that is robust to the variability in the different vehicle types (car, van, truck) and lighting conditions. In addition, we propose a new method to estimate the most likely three-dimensional locations of vehicles on the road ahead. With regards to the lane-markings estimation component, we have two main contributions. First, we employ a different image feature to the other commonly used edges: we use ridges, which are better suited to this problem. Second, we adapt RANSAC, a generic robust estimation method, to fit a parametric model of a pair of lane markings to the image features. We qualitatively assess our vehicle detection system in sequences captured on several road types and under very different lighting conditions. The processed videos are available on a web page associated with this paper. A quantitative evaluation of the system has shown quite accurate results (a low number of false positives and negatives) at a reasonable computation time.
Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation (2022)

Stem cell technologies provide new opportunities for modeling cells in health and disease and for regenerative medicine. In both cases, developmental knowledge and defining the molecular properties and quality of the cell types is essential. In this study, we identify developmental factors important for the differentiation of human embryonic stem cells (hESCs) into functional midbrain dopaminergic (mDA) neurons. We found that laminin-511, and dual canonical and non-canonical WNT activation followed by GSK3β inhibition plus FGF8b, improved midbrain patterning. In addition, neurogenesis and differentiation were enhanced by activation of liver X receptors and inhibition of fibroblast growth factor signaling. Moreover, single-cell RNA-sequencing analysis revealed a developmental dynamics similar to that of the endogenous human ventral midbrain and the emergence of high-quality molecularly defined midbrain cell types, including mDA neurons. Our study identifies novel factors important for human midbrain development and opens the door for a future application of molecularly defined hESC-derived cell types in Parkinson disease.
Erfahrungen mit einem neuen Ultraschallkontrollsystem für die zerstörungsfreie Prüfung von Präzisionsrohren (1977)

Article Erfahrungen mit einem neuen Ultraschallkontrollsystem für die zerstörungsfreie Prüfung von Präzisionsrohren was published on September 1, 1977 in the journal Materials Testing (volume 19, issue 9).
The IRESTE On/Off (IRONOFF) dual handwriting database (1999)

Databases for character recognition algorithms are of fundamental interest for the training of statistics based recognition methods (neural networks, hidden Markov models) as well as for benchmarking existing recognition systems. Such databases currently exist, but none of them gives access to the online data (pen trajectory) and offline data (digital images) for the same writing signal. We have developed such a dual on/off database, named IRONOFF. Currently, it contains a large number of isolated characters, digits, and cursive words written by French writers. We have designed this database so that, given an online point, it can be mapped at the correct location in the corresponding scanned image, and conversely, each offline pixel can be temporally indexed. Since we think this database is of interest for a large part of the research community, it is publicly available.
Systemic Therapy in Men With Metastatic Castration-Resistant Prostate Cancer: American Society of Clinical Oncology and Cancer Care Ontario Clinical Practice Guideline (2020)

To provide treatment recommendations for men with metastatic castration-resistant prostate cancer (CRPC).
Net Ultrafiltration in Peritoneal Dialysis: Role of Direct Fluid Absorption into Peritoneal Tissue (1992)

'Net ultrafiltration' in peritoneal dialysis refers to the difference between the osmotically induced ultrafiltration into the peritoneal cavity and the fluid loss from the cavity during dialysis. Recent research has demonstrated that, during a 3- to 4-hour experimental dialysis, 5-25% of the total fluid loss is via lymphatics and the remaining fluid is absorbed directly into the tissue surrounding the peritoneal cavity. The driving force for this convection into tissue is the hydrostatic pressure gradient between the peritoneal cavity and the tissue, which ranges from 2 to 8 mm Hg during the typical 2-liter dialysis in humans. Because the convection from the cavity occurs during periods of a positive net ultrafiltration, the peritoneum and its underlying tissue cannot be represented as a single membrane but function as a composite of 'tight' and 'loose' membranes. More data on the mechanical properties of the peritoneal tissue space and its response to hydrostatic pressure in the cavity are required before we fully understand fluid transport at the tissue level.
FX1000: a high performance single chip Gigabit Ethernet NIC (2002)

We present the design of the FX1000, a high performance single chip Gigabit Ethernet NIC. With a 64 bit, 66 MHz PCI bus interface the chip can maintain a throughput of 2 Gbps between memory and the network. The 64-bit address also allows the FX1000 to address very large system memory. In addition, it transmits and receives packets with minimal assistance from the CPU. Furthermore, the FX1000 performs TCP checksum calculation and IEEE 802.1q virtual LAN processing in hardware.
using multiple electrode aggregometry (2010)

Background: Poor platelet inhibition by aspirin or clopidogrel has been associated with adverse outcomes in patients with cardiovascular diseases. A reliable and facile assay to measure platelet inhibition after treatment with aspirin and a P2Y12 antagonist is lacking. Multiple electrode aggregometry (MEA), which is being increasingly used in clinical studies, is sensitive to platelet inhibition by aspirin and clopidogrel, but a critical evaluation of MEA monitoring of dual antiplatelet therapy with aspirin and P2Y 12 antagonists is missing. Design and Methods: By performing in vitro and ex vivo experiments, we evaluated in healthy subjects the feasibility of using MEA to monitor platelet inhibition of P2Y12 antagonists (clopidogrel in vivo, cangrelor in vitro) and aspirin (100 mg per day in vivo, and 1 mM or 5.4 mM in vitro) alone, and in combination. Statistical analyses were performed by the Mann-Whitney rank sum test, student' t-test, analysis of variance followed by the Holm-Sidak test, where appropriate. Results: ADP-induced platelet aggregation in hirudin-anticoagulated blood was inhibited by 99.3 ± 1.4% by in vitro addition of cangrelor (100 nM; p 95% and 100 ± 3.2%, respectively (p < 0.01). Aspirin did not influence ADP-induced platelet aggregation, either in vitro or ex vivo. Oral intake of clopidogrel did not significantly reduce AAinduced aggregation, but P2Y 12 blockade by cangrelor (100 nM) in vitro diminished AA-stimulated aggregation by 53 ± 26% (p < 0.01). A feasibility study in healthy volunteers showed that dual anti-platelet drug intake (aspirin and clopidogrel) could be selectively monitored by MEA. Conclusions: Selective platelet inhibition by aspirin and P2Y12 antagonists alone and in combination can be rapidly measured by MEA. We suggest that dual anti-platelet therapy with these two types of anti-platelet drugs can be optimized individually by measuring platelet responsiveness to ADP and AA with MEA before and after drug intake.
p16 and ARF: activation of teenage proteins in old age (2004)

Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus — p16INK4a and ARF — arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein– and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging.
Flexible Loop in the Structure of S-Adenosylmethionine Synthetase Crystallized in the Tetragonal Modification (1996)

S-Adenosylmethionine synthetase (MAT, ATP:L-methionine S-adenosyltransferase, E.C.2.5.1.6.) plays a central metabolic role in all organisms. MAT catalyzes the two-step reaction which synthesizes S-adenosylmethionine (AdoMet), pyrophosphate (PPi) and orthophosphate (Pi) from ATP and L-methionine. AdoMet is the primary methyl group donor in biological systems. MAT from Escherichia coli was crystallized in the tetragonal modification with space group P4(3)2(1)2 using the same conditions as previously yielded crystals of the hexagonal system [Takusagawa, et al., (1996), J. Biol. Chem. 171, 136-147], except for the crystallization temperature. The structure has been determined by molecular replacement at 3.2 A resolution. The overall structure of the tetrameric MAT in the tetragonal modification is essentially the same as the structure found in the hexagonal modification. However there are two remarkable differences between the structures of two modifications. One is the contents in the active sites (holoform vs. apo-form), and the other is the conformation of the flexible loop over the active site (open vs. closed). These differences in the crystal structures are caused solely by the difference in crystallization temperatures (26 degrees C vs. 4 degrees C). We have interpreted the structural data obtained from the X-ray analyses in conjunction with the results of the mechanistic and sequencing studies in terms of possible dynamic motion of the flexible loop. When a substrate/product binds in the active site (hexagonal modification), the loop becomes disordered, apparently due to flexibility at the entrance of the active site as if it acts as a "mobile loop" during the catalytic reaction. On the other hand, when the temperature is decreased, the dynamic motion of the flexible loop may be reduced, and the loop residues enter the active site and close its entrance (tetragonal modification). Thus, the active site of the tetragonal modification is empty despite the crystals being grown in mother liquor containing a large concentration of phosphate (100 mM). There is no significant displacement of amino acid residues in the active site between the holo and apo forms, suggesting that the flexible loop plays an important role in determination of the contents in the active site. Since the functionally important amino acid residues in the active site are all conserved throughout various species, the structures of the active sites and the mechanism of the catalysis are probably essentially identical in the enzymes from a wide range of organisms. However, the substrate KM and Vmax values of MATs from various species are distributed over a wide range. The amino acid residues in the flexible loop regions are poorly conserved throughout various species. Therefore, the wide differences in catalysis rates of MATs from various speeches may be due to the differences in the composition of the flexible loop.
"Spatial forming"-a three dimensional printing process (2005)

A three-dimensional printing process which we call “spatial forming” has been conceived and demonstrated as a method of manufacturing parts for cardiac catheter systems.’ This work extends the range. of particulate forming techniques into the niicrostructure area; brings to bear on the manufacture of three-dimensional structures the high production capabilities of offset lithography; and allows us to visualize a complete process for the volume production of objects and assemblies of a geometric complexity hitherto found only in nature. This process combines several technologies to generate solid metallic microstructures from fine powder. Cross section data from computer solid niodcls are used for patterning of a chrome mask which images a lithographic printing plate like those used in the publishing industry. A custom built offset printin9 press prints “negative” material (the space around the parts) on a ceramic substrate in multiple registered layers of ceramic pigmented organic ink averaging 0.5 pm thick; each layer is cured with L5’ light. Periodically an ink heavily loaded with finely powdered metal is knifed onto the substrate, filling the non-image voids with “positive” part material. This material is also UV cured, the surface planarized, and the entire printing process repeated in proper register until the desired thickness (e.g. -SO0 pm) is reached. The semi-finished parts are then debinderized to remove organic ink components, and sintered in controlled atmosphere futnaces in processe.s similar to those used in the metal injection molding industr).. The negative material crumbles away and the finished paits separate from the substrate.
THERMO-MECHANICAL TESTS ON METAMORPHIC ROCKS USING A SHEARING MACHINE (1978)

THE INTRODUCTION OF THE PRINCIPLE OF ENERGY STORAGE INTO THE FIELD OF ROCK MECHANICS LEADS TO CLOSER CONSIDERATION OF THE THERMAL SYMPTOMS WHICH ACCOMPANY THE ELEMENTAL AND MECHANICAL TRANSFORMATIONS WITHIN A ROCK MASS OR AT ITS DISCONTINUITIES. THE PAPER DESCRIBES LABORATORY TESTS WHICH WERE CONDUCTED ON SUCH DISCONTINUITIES AND IN WHICH THE HEAT RISE WITHIN A FISSURE WAS MEASURED USING SIMPLE SHEAR TESTS WITH MATERIAL WITH PRE-CUT FISSURES. THE NUMERICAL EVALUATION OF THE HEAT RISE IS GIVEN BY THE TEMPERATURE DISTRIBUTION EXPECTED USING CERTAIN ASSUMPTIONS CONCERNING LOAD DISTRIBUTION. THE RESULTS SHOW THAT THE PROBABLE CONTACT AREA IS CONSIDERABLY SMALLER THAN THE AREA CUT ON THE SAMPLE. SUCH A BUILD UP OF STRESS SHOULD LEAD TO A PROOF OF THE VALIDITY OF THE ASSUMPTIONS ON WHICH THE STABILITY CALCULATIONS FOR THE ROCK MASS ARE USUALLY BASED.