gebhart/patrepeval huggingface dataset:
354345 INTEGRATED TILT AND ACTIVE LATERAL SECONDARY SUSPENSION CONTROL(Bogie,Technical Session) (2009)

This paper describes a theoretical study on the integration of tilt and active lateral secondary suspension control issues relate to the system performance requirements, controller assessment approaches, modelling process and dynamics interaction analysis. Two dual-actuator control system configurations with classical decentralized controllers are presented. The work aims to improve the performance of a tilt controller based only upon local vehicle measurements by integrating the lateral active secondary suspension with the roll (tilt actuator). The effectiveness of the integrated control is illustrated via simulations and comparisons with previous modified nulling tilting control as well as the commercial precedence equivalent.
A Causal Role for the Human Tumor Antigen Preferentially Expressed Antigen of Melanoma in Cancer (2006)

Tumor antigens are of interest as diagnostic and prognostic markers and potential therapeutic targets. The tumor antigen preferentially expressed antigen of melanoma (PRAME) is frequently overexpressed in a wide variety of cancers and is a prognostic marker for clinical outcome. It has been shown recently that PRAME functions as a repressor of retinoic acid signaling. Here, we discuss this novel insight in the context of the increasing interest in tumor antigens as targets for therapy.
Least-squares estimation of time-base distortion of sampling oscilloscopes (1999)

We present an efficient least-squares algorithm for estimating the time-base distortion of sampling oscilloscopes. The method requires measurements of signals at multiple phases and frequencies. The method can accurately estimate the order of the harmonic model that is used to account for the amplitude nonlinearity of the sampling channel. We study several practical problems related to the time-base distortion estimation, such as the effect of averaging and sample size requirements. We also compare the relative performance of various methods for estimating time-base distortion using simulated and measured data.
Synthesis of Novel Cationic Lipids Having Polyamidoamine Dendrons and Their Transfection Activity (2003)

We designed a novel type of cationic lipid, lipids with a cationic polar group in the polyamidoamine dendron, because these dendron-bearing lipids are expected to form complexes with plasmid DNA and achieve efficient transfection of cells by synergy of endosome buffering and membrane fusion with the endosome, both of which are useful for the promotion of the transfer of plasmid DNA from endosome to cytosol. Four kinds of lipids with polyamidoamine dendrons of first to fourth generations, DL-G1, DL-G2, DL-G3, and DL-G4, were synthesized. The lipid with a dendron of a higher generation exhibited greater ability to form lipoplexes with plasmid DNA, as estimated by agarose gel electrophoresis. While the DL-G1 lipoplex did not transfect CV1 cells, the lipoplexes containing the DL-G2, DL-G3, or DL-G4 could induce transfection of the cells, and their activity was elevated with increasing generation of the dendron. Addition of dioleoylphosphatidylethanolamine (DOPE), which is known to increase fusion ability of a lipid membrane, into the lipoplexes greatly enhanced their transfection activity. In addition, the comparison with DC-Chol-containing lipoplex, which is widely used as a nonviral vector, showed that the DL-G3-DOPE lipoplex exhibits more efficient transfections. These findings imply that these dendron-bearing lipids may form the basis for a novel family of cationic lipids for efficient gene delivery.
A floating well method for exact capacitance-voltage measurement of nano technology (2003)

Small gate area with short gate length reduces the C-V distortion of ultrathin oxide devices, but results in high parasitic capacitance/total capacitance ratio. The floating well method can exclude the parasitic capacitance to obtain accurate inversion oxide thickness without using any dummy pattern. It is suitable for nano technology.
Reliability of quantum well and quantum dot lasers for silicon photonics (invited) (2017)

After discussing the reliability issues limiting existing quantum well InP-based lasers, and the past reliability challenges of lasers grown on silicon substrates, we will show the recent reliability test results of a number of different types of quantum dot lasers grown on different silicon-substrate templates.
Bidirectional modulation of endogenous EpCAM expression to unravel its function in ovarian cancer (2020)

Background:The epithelial cell adhesion molecule (EpCAM) is overexpressed on most carcinomas. Dependent on the tumour type, its overexpression is either associated with improved or worse patient survival. For ovarian cancer, however, the role of EpCAM remains unclear.Methods:Cell survival of ovarian cancer cell lines was studied after induction or repression of endogenous EpCAM expression using siRNA/cDNA or artificial transcription factors (ATF) consisting of engineered zinc-fingers fused to either a transcriptional activator or repressor domain.Results:Two ATFs were selected as the most potent down- and upregulator, showing at least a two-fold alteration of EpCAM protein expression compared with control. Downregulation of EpCAM expression resulted in growth inhibition in breast cancer, but showed no effect on cell growth in ovarian cancer. Induction or further upregulation of EpCAM expression decreased ovarian cancer cell survival.Conclusion:The bidirectional ATF-based approach is uniquely suited to study cell-type-specific biological effects of EpCAM expression. Using this approach, the oncogenic function of EpCAM in breast cancer was confirmed. Despite its value as a diagnostic marker and for immunotherapy, EpCAM does not seem to represent a therapeutic target for gene expression silencing in ovarian cancer.
A dynamic online background modeling framework for moving object detection from airborne videos (2015)

Current researches on moving object detection from airborne videos are mainly based on frame difference. Though many improvements have been made on these methods, it is still difficult to extract all the moving pixels accurately. Being capable of providing more reliable motion information, background subtraction based methods have been widely used for analyzing surveillance videos captured by fixed cameras. In this paper, we design a dynamic online background modeling framework to facilitate the adaption of the available background subtraction algorithms for moving object detection from airborne videos. It can avoid accumulated stabilization errors and handle the pixels near the frame boundary well. The advantage of our framework lies in the stabilization strategies we proposed and the background model size we employed. Experimental results and analysis on the airborne videos have validated the effectiveness of the proposed framework.
Determination of peimine and peiminine in Bulbus Fritillariae Thunbergii by capillary electrophoresis by indirect UV detection using N‐(1‐naphthyl)ethylenediamine dihydrochloride as probe (2012)

A simple and inexpensive CE method was developed for the determination of peimine and peiminine. Because of the lack of an UV chromophore of peimine and peiminine, the detection method chosen was indirect UV detection, with N-(1-naphthyl)ethylenediamine dihydrochloride (NED) as the UV absorbing probe. It was thought that NED, a chromophoric ion, may form hydrogen bonding pairs with the analytes to cause significant changes in separation selectivity. Additionally, the hydrophobic interactions between analytes and the probe also play a crucial role in achieving a resolution between the two analytes. The analyses were carried out with a background electrolyte composed of 66% MeOH-ACN (1:1, v/v), 34% aqueous buffer containing 15 mM NaH₂PO₄, 2.5 mM NED, 4 mM H₃PO₄. MeOH-ACN mixtures used as organic modifiers can not only reduce the adsorption of NED to the capillary wall, but also decrease the baseline noise and drift. The method provided a linear response ranging from 5 to 200 μg/mL. The limits of detection (LODs) for peimine and peiminine were 3.9 and 4.1 μg/mL, respectively. The repeatabilities (n = 3) reached relative standard deviation values (RSDs) of 3.4 and 4.1% for the peak areas, 4.0 and 4.4% for the peak heights, and 0.29 and 0.30% for the migration time of peimine and peiminine, respectively. Regression equations revealed linear relationships (r = 0.9995-0.9996) between the peak area of each analyte and the concentration. The method developed was successfully applied to quantify peimine and peiminine in chloroform extracts of the ground Bulbus Fritillariae Thunbergii.
The Design and Synthesis of Long-Acting Oxytocin Antagonists Substituted in Positions 2, 7, and 8 (1994)

The design of oxytocin antagonists (for reviews, see Hruby and Mosberg, 1982; Hruby and Smith, 1987; Hruby et al., 1990; Lebl, 1987; Manning and Sawyer, 1989; Sawyer and Manning, 1985) has increasingly involved a search for structural changes that would enhance both in vivo potency and increase duration of action. The discovery of Shulz and du Vigneaud (1966, 1967) and Jost et al. (1961) that substituting more bulky amino acids in either position 1 (penicillamine) or position 2 (O-methyltyrosine) produced oxytocin antagonists has led to numerous further investigations into the structural and conformational requirements important for antagonism at the uterine oxytocin receptor (Hruby, 1985; Hruby et al., 1990; Manning and Sawyer, 1989; Meraldi et al., 1975, 1977). Since these pioneering studies, many important, more potent antagonists have been reported, particularly by the groups of Manning et al., Melin et al., Lebl et al., and Hruby et al. (Hruby and Smith, 1987; Lebl, 1987; Manning and Sawyer, 1985) primarily by incorporating appropriate amino acid substitutions into positions 1, 2, 4, 7, and 8, including linear analogs (Manning et al., 1987).
Synthesis of isoflavones. Part V. Irigenin and tectorigenin (1970)

The general ethoxalylation procedure for the synthesis of isoflavones has been applied to the synthesis of irigenin (VII) and tectorigenin (XVI). This synthetic route also yields the isomers, ψ-irigenin (XI) and ψ-tectorigenin (XX). Information concerning the product ratio in certain ethoxalylation reactions and the relative thermodynamic stabilities of 5,6,7- and 5,7,8-trisubstituted isoflavones is discussed.
Interaktion als Dienst in Mundo (2003)

Beim Ubiquitous Computing sollen unzahlige verschiedene Gerate in spontaner Kooperation Dienste auf intelligente und benutzerfreundliche Weise erbringen. Ein Dienst konnte z.B. je nach Situation des Benutzers mal ein Display und mal Sprache zur Interaktion nutzen. Solch intelligentes Verhalten sollte automatisch bereitgestellt werden, anstatt jeden Entwickler von neuem mit der Komplexitat der Interaktionsinfrastruktur zu konfrontieren. Wir zeigen, wie eine Middleware fur Interaktion in einer solchen Umgebung aussehen kann, und wie man mit einfachen Mitteln eine existierende Webapplikation ubiquitar verfugbar machen kann.
Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice (2023)

Myoglobin (MB) is expressed in different cancer types and may act as a tumor suppressor in breast cancer. The mechanisms by which basal MB expression level impacts murine mammary tumorigenesis are unclear. We investigated how MB expression in breast cancer influences proliferation, metastasis, tumor hypoxia, and chemotherapy treatment in vivo. We crossed PyMT and WapCreTrp53<sup>flox</sup> mammary cancer mouse models that differed in tumor grade/type and onset of mammary carcinoma with MB knockout mice. The loss of MB in WapCre;Trp53<sup>flox</sup> mice did not affect tumor development and progression. On the other hand, loss of MB decreased tumor growth and increased tissue hypoxia as well as the number of lung metastases in PyMT mice. Furthermore, Doxorubicin therapy prevented the stronger metastatic propensity of MB-deficient tumors in PyMT mice. This suggests that, although MB expression predicts improved prognosis in breast cancer patients, MB-deficient tumors may still respond well to first-line therapies. We propose that determining the expression level of MB in malignant breast cancer biopsies will improve tumor stratification, outcome prediction, and personalized therapy in cancer patients.
Fluidic MEMS based Biosensor for the Detection of Nucleic acids by using Schizophyllan (2005)

Recently, a fluid micro electro mechanical system (fluid MEMS), which is composed of a micro pump, mixer, valve, reactor, sensor, an electric circuit, on a chip, is being applied to a biotechnology or a medical analysis. Authors developed a micro sensor mounted on a chip to measure a concentration of one drop of solution (1nL-10μL) which contained nuclear acids. The form of the micro sensor mounted on the chip was a pair of Cu electrode which was a diameter of 2mm and was a thickness of 10μm. The sensing function was evaluated by the changes in a concentration of poly(x) (x=adenine, guanine, uracil, and cytosine) solution which was dropped on a micro sensor.To increase a recognization against nucleic acid, various adsorbent was added in a droplet. Especially, high recognition against the nucleic acid was observed with the adsorbent which modified the surface of polystyrene micro beads(10μm) using schizophyllan: a kind of polysaccharide. This biosensor recognized a small quantity of total-RNA and m-RNA extracted from the yeast.
The Kalman filter: an introduction to the mathematics of linear least mean square recursive estimation (1986)

This paper introduces the fundamental ideas of Kalman filtering, a recursive estimation technique widely used for continuous estimation of the state of a dynamic system. The estimation problem is posed within the well known Hilbert space framework of classical linear analysis. This permits an easily grasped geometric interpretation which is stripped of cumbersome details that tend to obscure the essential notions. Considerable emphasis is placed on the development of the mathematical models for the state and measurement equations. A practical example of a real‐world dynamic system (the motion of a ship) is used to motivate the form of the state equation required in Kalman filtering, as well as the measurement equation. The recursive estimator and error covariance equations are derived for a one‐dimensional dynamic system using a sequence of geometric visualizations as the derivation proceeds. The more tedious algebraic manipulations, which are not needed for an essential understanding of the derivation, are relegated to Appendices. This approach removes distracting details which often accompany derivations found in the engineering literature, and makes it apparent that Kalman filtering is based on elegant classical mathematics.
Statistical Coarse-graining of Classical Mechanics into Peridynamics. (2020)

Abstract not provided.
Structure and disorder in single-crystal lead zirconate, PbZrO3 (1993)

The full three-dimensional single-crystal crystal structure of the perovskite material PbZrO 3 (M r =346.42) has been refined. It is found that the structure is disordered with two substructure components related by a shear of c/2. Each individual substructure corresponds closely to the tilt system a - a - c 0 of Glazer [Acta Cryst. (1972), B28, 33843392; Acta Cryst. (1975), A31, 756-762]. The space group was determined to be Pbam (D o 2h ) with a=5.889 3), b=11.784 (4) and c=8.226 (2) A, V=570.8 (4) A 3 , Z=8, D x =8.06 Mg m -3 , Mo Kα, λ=0.71069 A, μ=612.68 cm -1 , T=297 K
A showcase of adaptive controller designs (1989)

Abstract The adaptive control literature contains hundreds of technical papers on many different approaches to the subject. However, engineers who are not specialists in adaptive theory often have difficulty selecting which approach to use in any given problem. This series of papers addresses this situation by defining a set of standard problems which are then solved by several distinct approaches to adaptive control. This introductory paper defines the problems and guidelines which have been used in this process.
ChemInform Abstract: SYNTHETIC STUDIES ON β‐LACTAM ANTIBIOTICS. 12. STEREOCONTROLLED SYNTHESIS OF 7α‐METHOXY‐1‐OXACEPHEMS FROM 6‐EPIPENICILLIN G (1979)

Abstract Das aus dem Penicillin‐G‐ester (Ia) zugängliche 6‐Epirnere (Ib) wird in einem Eintopfverfahren über das Secochlorid (II) in das Epioxazolin (III) übergeführt, aus dem mitA1lyla1koho1 (IV) der trans‐ Ether (V) dargestellt wird.
Blue Phosphorescence and Hyperluminescence Generated from Imidazo[4,5‐b]pyridin‐2‐ylidene‐Based Iridium(III) Phosphors (2022)

Four isomeric, homoleptic iridium(III) metal complexes bearing 5-(trifluoromethyl)imidazo[4,5-b]pyridin-2-ylidene and 6-(trifluoromethyl)imidazo[4,5-b]pyridin-2-ylidene-based cyclometalating chelates are successfully synthesized. The meridional isomers can be converted to facial isomers through acid induced isomerization. The m-isomers display a relatively broadened and red-shifted emission, while f-isomers exhibit narrowed blue emission band, together with higher photoluminescent quantum yields and reduced radiative lifetime relative to the mer-counterparts. Maximum external quantum efficiencies of 13.5% and 22.8% are achieved for the electrophosphorescent devices based on f-tpb1 and m-tpb1 as dopant emitter together with CIE coordinates of (0.15, 0.23) and (0.22, 0.45), respectively. By using f-tpb1 as the sensitizing phosphor and t-DABNA as thermally activated delayed fluorescence (TADF) terminal emitter, hyperluminescent OLEDs are successfully fabricated, giving high efficiency of 29.6%, full width at half maximum (FWHM) of 30 nm, and CIE coordinates of (0.13, 0.11), confirming the efficient Förster resonance energy transfer (FRET) process.
High Voltage Charging of a Capacitor Bank (2008)

We have demonstrated the feasibility of charging a capacitor bank to a high voltage using an autonomous ultra-compact explosively driven source of prime power. The prime power source is a longitudinally driven shock wave depolarization of a ferroelectric ceramic. The energy-carrying elements of the shock wave ferroelectric generators (FEGs) were poled Pb(Zr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">52</sub> Ti <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">48</sub> )O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> polycrystalline ceramic disks with 0.35 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> volume. FEGs charged 9 nF, 18 nF, and 36 nF capacitor banks and provided pulsed-power with peak amplitudes up to 0.29 MW. The maximum efficiency of electric charge transfer from shocked Pb(Zr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">52</sub> Ti <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">48</sub> )O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> elements to a capacitor bank was 46%. We demonstrated experimentally that the FEG-capacitor bank system can perform as an oscillatory circuit. A methodology was developed for numerical simulation of the operation of the FEG-capacitor bank system; the simulation results were in a good agreement with the experimental results.
STARMINE: a visualization system for cyber attacks (2006)

In cyber attack monitoring systems, various types of visualizations, such as geographical visualization, temporal visualization, logical visualization, are being used. Each visualization has its own advantages and disadvantages. Since it is important to analyze the information from di#erent viewpoints and to make a right decision in practical cyber attack monitoring, these visualization should be highly integrated.
Selective Targeting of Integrin αvβ8 by a Highly Active Cyclic Peptide (2019)

Integrins play important roles in physiological and pathophysiological processes. Among the RGD-recognizing integrin subtypes, the αvβ8 receptor is emerging as an attractive target because of its involvement in various illnesses, such as autoimmune diseases, viral infections, and cancer. However, its functions have, so far, not been investigated in living subjects mainly because of the lack of a selective αvβ8 ligand. Here, we report the design and potential medical applications of a cyclic octapeptide as the first highly selective small-molecule ligand for αvβ8. Remarkably, this compound displays low nanomolar αvβ8 binding affinity and a strong discriminating power of at least 2 orders of magnitude versus other RGD-recognizing integrins. Peptide functionalization with fluorescent or radioactive labels enables the selective imaging of αvβ8-positive cells and tissues. This new probe will pave the way for detailed characterization of the distinct (patho)physiological role of this relatively unexplored integrin, providing a basis to fully exploit the potential of αvβ8 as a target for molecular diagnostics and personalized therapy regimens.
Tablet Coating in an Aqueous System (1977)

We have studied about the operation technique of film coating with HPMC, Pharmacoat which is our product name, and show here some data in commercial scale using mainly aqueous system which is expected to be carried out in the near future throughout the world.
ACORN strategic report (2013)

The 2012-2014 Board is working consistently towards the strategic direction set by them at the November 2012 board meeting. The Board at the recent meeting in February reviewed the strategic direction by identifying what has been achieved in the first year of this Board and what goals need to be set for the following year. The Board accomplishes its outcomes through the work of each ACORN Committee. This report will review each committee's achievements.
Comparison of Bovine Blood Absorption Coefficients to Human Curves (2008)

Specific curves for the light extinction coefficients of hemoglobin have been generated using oxygenated and deoxygenated human blood samples. These curves are often used with animal blood samples to measure oxygen saturation. This project aims to compare samples of oxygenated and deoxygenated bovine blood to these standard human curves. Creating a large surface area and exposing blood samples to air created oxygenated blood samples. The deoxygenated samples were created using sodium dithionite. Four pairs of samples were placed in a spectrometer to measure light transmission and this data was converted to absorption values. These values were then compared to the given curves. For 48% of the wavelengths between 650 and 1000 nm, the standard curve was within 2 standard deviations.
Scanning tunneling microscopy using dynamic laser heating (2005)

A hydrogen passivated Si(100)-2/spl times/1 surface is studied using ultrafast laser excitation with a novel total internal reflection geometry. The incoherent tip and sample heating dynamics are studied, and it is shown that as long as the STM feedback is faster than the heating and cooling processes, atomic scale imaging can be achieved, even in the presence of significant tip and sample expansion and contraction. This opens the door for studies of surface processes on the ultrafast timescale.
Implementation of Fuzzy Logic Controller (FLC) for DC-DC Boost Converter Using Matlab/Simulink (2017)

Nowadays, DC-DC converters circuits are widely used in electronics systems in order to obtain a stabilized output voltage from a given input DC Voltage. Performance of DC-DC converters is dependent on the choice of control methods. Consequently, controlling of DC-DC converter represents essential task in power conversion.The research problem addressed in this paper is to model a controlling system for Boost DC-DC converter. In this way a logic fuzzy controller is used and simulated using MATLAB/SIMULINK to increase converter efficiency and power efficiency.