gebhart/patrepeval huggingface dataset:
RB 101, A Purported Pro Drug Inhibitor of Enkephalin Metabolism, Is Antinociceptive in Pregnant Mice (1997)

In an earlier study, we demonstrated the enhancement of pregnancy-induced analgesia with an inhibitor of endogenous enkephalin metabolism. The purpose of the present study was to evaluate the antinociceptive effect of another inhibitor of enkephalin metabolism, RB 101, on pregnant mice. Further, since other studies have shown RB 101 to be free of opioid side effects, we examined its effect on respiratory rate. Analgesia was assessed using the hot plate test, and respiratory rate was measured by recording the output from an end-tidal carbon dioxide detector. In pregnant mice, experiments were conducted on Day 17 or Day 18 of pregnancy; mice usually deliver on Day 19. For the hot plate test, animals were tested in the following groups: Group 1, RB 101 150 mg/kg (n = 15); Group 2, RB 101 50 mg/kg (n = 15); Group 3, RB 101 vehicle (n = 15); Group 4, morphine 5 mg/kg (n = 14); and Group 5, RB 101 150 mg/kg + naloxone 5 mg/kg (n = 10). The test was repeated on the second day after delivery in animals in Groups 1 and 3 (given RB 101 150 mg/kg and RB 101 vehicle, respectively). RB 101 150 mg/kg and morphine 5 mg/kg were significantly different (mean percentage of maximum possible effect 30.0 and 37.7, respectively, at 30 min and 41.6 and 32.6, respectively, at 60 min) in their antinociceptive effect in pregnant animals from all other groups. Naloxone, when coadministered with RB 101, prevented the development of antinociception. RB 101 150 mg/kg was not antinociceptive after delivery. Depression of respiratory rate was tested in a separate set of animals in the following groups: Group 1, RB 101 150 mg/kg (n = 16); Group 2, morphine 5 mg/kg (n = 16); Group 3, RB 101 vehicle (n = 15). Morphine 5 mg/kg produced significant depression of respiratory rate at 30 min postinjection when compared with RB 101 150 mg/kg and RB 101 vehicle (mean percent change in respiratory rate was 78.5% compared with 87.7% and 92.4%, respectively, where 100% = no change). These results suggest that drugs such as RB 101 may produce antinociception with minimal effects on respiration. (Anesth Analg 1997;84:355-8)
Outcomes from the first mouth cancer awareness and clinical check-up day in the Dublin Dental University Hospital. (2012)

The diagnosis of five people with mouth cancers, who may not otherwise have been identified for early treatment, highlights the need for regular mouth examination. It is inappropriate that such an exercise would remain the preserve of the dental teaching hospitals, and it is vital that all dentists take on the responsibility for regular mouth checks for all of their patients. More should be done to encourage those identified as high risk to visit their dentist. There is a need for recognition of the additional resources required for the detection and timely management of such cancers.
Microfluidics to fabricate and probe vesicles mimicking cells (2019)

International audience
20–300 MHz frequency generator with −70 dBc reference spur for low jitter serial applications (2016)

This paper presents a frequency synthesizer based on a phase locked loop (PLL) targeting low jitter applications. The frequency generator covers a range wider than a decade, more explicitly from 20 to 300 MHz. Thanks to a 4-stage ring oscillator, it can provide quadrature signals and exhibit a -117 dBc/Hz phase noise at an offset of 1 MHz from the carrier. Settling time simulations on MATLAB and Cadence Spectre match with measurement results, which yield maximum 1.3 μs (or 26 reference cycles) for N to N+1 switching, while N denotes the integer division ratio. PLL core draws a current less than 5 mA when it is supplied from a 1.8 V dc supply. PLL is driven by a 20 MHz clock source having 0.67 ps rms jitter. At 200 MHz, the circuit provides a differential output with 2.05 ps rms jitter (equivalent to 0.41 mUI) within an integration window from 10 Hz to 40 MHz and creates a reference spur lower than -70 dBc.
Продольная когерентность оптического поля протяженного пространственно некогерентного источника (2009)

Longitudinal coherence of optical field of an extended spatially noncoherent light source is considered depending on parameters of frequency and angular spectra of this field. The expressions for function and length of longitudinal coherence of an optical field are received depending on width frequency and width of angular spectra of the field. The competing influence of angular and frequency spectra of the field on its longitudinal coherence is discussed. The experimental researches with use scanning Michelson interferometer of longitudinal shift confirming the theoretical results are executed.
Role of oxygen inPrBa2Cu3O7−y: Effect on structural and physical properties (1990)

${\mathrm{PrBa}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{7\mathrm{\ensuremath{-}}\mathit{y}}$ is the only homomorphic member of the entire rare-earth 1:2:3 family which is insulating and not metallic or superconducting. With this unusual behavior in mind, and with an eye to resolving certain questions regarding the widely held notion of otherwise mobile holes held captive in a supratrivalent Pr ionic state as its cause, we examined the effect of varying oxygen concentration on the structural, electrical, and magnetic properties of this compound. Powder x-ray diffraction studies revealed an orthorhombic-to-tetragonal order-disorder transition at oxygen levels close to those found for the superconducting lanthanide compounds. From Rietveld-refined powder-neutron-diffraction data taken on a fully oxygenated sample, key insights into the ambivalent character of Pr valency were obtained. Other aspects of Pr valency and carrier dynamics were uncovered by electrical and magnetic measurements as a function of y. We found that the room-temperature resistivity increases by about three orders of magnitude from y\ensuremath{\simeq}0 to y\ensuremath{\simeq}0.5, while the temperature dependence of the paramagnetic susceptibility remains quantitatively the same. We conclude from these results that removal of oxygen from ${\mathrm{PrBa}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{7\mathrm{\ensuremath{-}}\mathit{y}}$ does not substantially alter the valence state of Pr, which we assert to be nominally 3+, but with strong overlap of its outer-lying 4f orbital with neighboring oxygen 2p levels results in a characteristically mixed or fluctuating valence situation reminiscent of heavy-fermion systems, and the principal effect on transport properties is on carrier concentration in the chains and steric hindrance of their motion by the resulting oxygen vacancies.
New “Cats” in the House: Chemistry Meets Biology in Artificial Metalloenzymes and Repurposed Metalloenzymes (2019)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTNew "Cats" in the House: Chemistry Meets Biology in Artificial Metalloenzymes and Repurposed MetalloenzymesJohn F. HartwigJohn F. HartwigUniversity of California, BerkeleyMore by John F. Hartwighttp://orcid.org/0000-0002-4157-468X and Thomas R. WardThomas R. WardUniversity of BaselMore by Thomas R. Wardhttp://orcid.org/0000-0001-8602-5468Cite this: Acc. Chem. Res. 2019, 52, 5, 1145Publication Date (Web):May 21, 2019Publication History Published online21 May 2019Published inissue 21 May 2019https://pubs.acs.org/doi/10.1021/acs.accounts.9b00154https://doi.org/10.1021/acs.accounts.9b00154editorialACS PublicationsCopyright © 2019 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views3210Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (243 KB) Get e-AlertscloseSUBJECTS:Catalysts,Genetics,Organometallic reactions,Peptides and proteins,Transfer reactions Get e-Alerts
Hierarchically Structured Nitrogen-Doped Multilayer Reduced Graphene Oxide for Flexible Intercalated Supercapacitor Electrodes (2020)

Intercalated flexible electrodes for energy storage devices have drawn significant research interests as they can provide high energy densities for powering electronics without sacrificing the overall flexibility. Herein, we report an intercalated reduced graphene oxide/polyacrylonitrile (rGO/PAN) flexible supercapacitor electrode fabricated via a layer-by-layer wet electrospinning (LLwES) process with diluted graphene oxide (GO) solution as the coagulation liquid and subsequent thermal reduction treatment. It was observed that a thin GO film was established on individual PAN nanofiber layer after the wet electrospinning process, while the subsequent thermal reduction of GO led to simultaneous stabilization of the PAN fibers and the creation of an interesting three-dimensional hierarchical carbon nanostructure suitable for flexible, high-performance electrochemical capacitor (EC) electrodes. The formation of gases during the thermal treatment expanded the electrospun PAN fiber layers and resulted in the formation of intercalated nitrogen-doped porosities. The resulting LLwES rGO/PAN system, thermally treated in a nitrogen atmosphere, demonstrated exceptional double-layer capacitance of 221 F/g at 10 mV/s, a controllable electrical conductivity of 125 S/m, and a stable cycling performance retaining a slightly increased capacitance after 10000 cycles.
Host-guest chemistry. 27. Mechanisms of macrocycle genesis. The condensation of resorcinol with aldehydes (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHost-guest chemistry. 27. Mechanisms of macrocycle genesis. The condensation of resorcinol with aldehydesFrank Weinelt and Hans Joerg SchneiderCite this: J. Org. Chem. 1991, 56, 19, 5527–5535Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/jo00019a011https://doi.org/10.1021/jo00019a011research-articleACS PublicationsRequest reuse permissionsArticle Views1308Altmetric-Citations104LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Practical, non-invasive optical probing for flip-chip devices (2002)

A new tool for performing picosecond imaging circuit analysis (PICA) is described. The tool has /spl plusmn/15 ps timing accuracy and can be used with a wide variety of testers. The key design decisions in and limitations of this PICA system are outlined. A low noise, low jitter imaging detector is employed to both visualize the emission sources and provide precise timing information. The daunting challenges of weak signals, image stabilization and complex data acquisition have been successfully met. We briefly describe new methodologies and tools that are needed to realize its potential as well as how such a PICA system could be adopted by debug and failure analysis teams.
Supplemental Table S1. from The Role of Proliferation in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer: A Gene Expression–Based Meta-Analysis (2023)

&lt;p&gt;Patient Characteristics By Study&lt;/p&gt;
Localization, synthetic regulation, and biology of renal atriopeptin-like prohormone (1992)

We recently demonstrated the synthesis and secretion of an atriopeptin (AP)-like prohormone in rat neonatal and adult cortical kidney cell cultures. However, these cultures contained proximal as well as distal tubular epithelial cells; thus characterization of the peptide synthetic cell was not possible. Also, by immunohistochemical techniques, we localized this AP-like prohormone to the distal cortical nephron in adult rat kidney. In this study, we examined further details of the kidney cortical cell type that expresses and secretes this AP-like peptide in adult renal cortical cell cultures, its regulation by adenylate cyclase via adenosine 3',5'-cyclic monophosphate (cAMP) generation, and its ability to stimulate guanylate cyclase. Tubular fragments were derived from cortical tissue of adult Sprague-Dawley rats and separated into four fractions on Percoll density gradient. Cell cultures generated from fraction 3 secreted 5- to 10-fold the amount of this renal peptide compared with fractions 2 and 4. Further cell culture characterization was performed by agonist-stimulated cAMP formation, kallikrein localization, and prostaglandin E2 formation. From these analyses, it was determined that tissue band 3 was enriched for distal cortical connecting tubules. To further evaluate whether mammalian distal nephron synthesizes an AP-like protein, we determined that two immortalized mouse cell lines, derived from either the distal convoluted tubule or cortical collecting tubule, synthesized a radiolabeled AP after being pulsed with [35S]-methionine.(ABSTRACT TRUNCATED AT 250 WORDS)
Single and multiple dose pharmacokinetics of nelfinavir and CYP2C19 activity in human immunodeficiency virus‐infected patients with chronic liver disease (2000)

Acquired CYP2C19 deficiency from moderate or severe liver disease resulted in decreased M8 formation. Long-term HIV suppression is possible using low nelfinavir doses in patients with liver disease.
MR Imaging of Pheochromocytomas (1985)

Magnetic resonance imaging (MRI) of seven patients with pheochromocytomas demonstrable by CT was performed. Magnetic resonance imaging showed all primary pheochromocytomas, as well as metastatic lesions to the thorax, retroperitoneum, and liver. The ability to distinguish pheochromocytomas from surrounding structures without the need of an intravenous contrast agent and to provide direct coronal and sagittal images suggests that MRI may be useful in detecting and localizing these tumors.
Synthesis, and antitubercular and antimicrobial activity of 1′-(4-chlorophenyl)pyrazole containing 3,5-disubstituted pyrazoline derivatives (2015)

A new series of pyrazoline derivatives was synthesized and characterized using spectral techniques. The synthesized compounds were evaluated for their antitubercular and antimicrobial activities. Most of the compounds are found to be biologically potent.
Enhanced HARQ for Delay Tolerant Services in Mobile Satellite Communications (2015)

The objective of our paper is to improve efficiency (in terms of throughput or system capacity) for mobile satellite communications. In this context, we propose an enhanced Hybrid Automatic Repeat reQuest (HARQ) for delay tolerant services. Our proposal uses the estimation of the mutual information. We evaluate the performance of the proposed method for a land mobile satellite channel by means of simulations. Results are compared with those obtained with a classical incremental redundancy (IR) HARQ scheme. The technique we propose, shows a better performance in terms of efficiency while maintaining an acceptable delay for services.
Antigenic Relationships among Simbu Serogroup (Bunyaviridae) Viruses (1981)

Antigenic relationships among 24 bunyaviruses of the Simbu serogroup were determined by complement-fixation (CF), serum dilution-plaque reduction neutralization (N) and, where possible, hemagglutination-inhibition (HI) tests. By CF, three distinct complexes of closely related viruses were identified within the serogroup. Nola and Thimiri viruses, which showed little relationship with other members of the serogroup, may represent two additional complexes. N tests in Vero cells showed that individual viruses generally were distinguishable with little difficulty. Aino and Kaikalur viruses were indistinguishable by CF or N. Seven viruses showed hemagglutination activity, and antigenic relationships among these viruses by HI paralleled those established by N tests. A classification scheme, based on both CF and N test results, for the viruses of the Simbu serogroup is proposed.
Graduate study in acoustics at the Georgia Institute of Technology (1988)

The graduate studies at Georgia Tech span across three colleges, Engineering, Liberal Arts and Sciences, and Architecture and seven schools. Starting with a sequence of three courses on the foundations of physical acoustics, courses in underwater acoustics, atmosphere acoustics, nonlinear acoustics, aeroacoustics, jet noise, noise control architectural acoustics, waves in elastic and viscoelastic media, nonlinear wave propagation, bioacoustics, and vibrations, are available for the formal educational development and preparation for research in acoustics. Opportunities for research across campus are plentiful in such areas as combustion, aerodynamic and helicopter noise, machinery noise, low-noise environmental design, etc. More specifically, at the school of Mechanical Engineering, studies currently in progress are in variational methods in wave propagation and in particular acoustics, light-sound interaction and laser applications to sound detection, fluid-structure interaction and sound propagation, radiation mechanisms, active vibration control, scaling effects, characterization of materials by waves, auditory systems of fish, provide a wealth of graduate thesis topics with a faculty actively engaged in these areas. In addition to the graduate degrees, the institute offers the opportunity for specialized study in acoustics through its multidisciplinary certificate program. Under this program, those who are not as heavily committed to graduate studies in acoustics can be exposed to the field and receive an acoustical engineering or acoustics certificate.
Overcoming Scalability Challenges for Tool Daemon Launching (2008)

Many tools that target parallel and distributed environments must co-locate a set of daemons with the distributed processes of the target application. However, efficient and portable deployment of these daemons on large scale systems is an unsolved problem. We overcome this gap with LaunchMON, a scalable, robust, portable, secure, and general purpose infrastructure for launching tool daemons. Its API allows tool builders to identify all processes of a target job, launch daemons on the relevant nodes and control daemon interaction. Our results show that LaunchMON scales to very large daemon counts and substantially enhances performance over existing ad hoc mechanisms.
Implications of modelling the chromophore of rhodopsin and bacteriorhodopsin with resonance Raman spectra of retinal Schiff bases (1979)

Abstract Resonance Raman spectra of protonated and unprotonated Schiff bases of all‐ trans retinal with propylamine, hexylamine, butylamine, deuterated butylamine ( d 9 ), methylamine and N 15 methylamine have been obtained. The spectra of methylated and deuterated butylamine Schiff bases of retinal have also been recorded. It was found that the carbon–nitrogen stretching vibration associated with the Schiff base is insensitive to changes in the mass and/or length of the saturated hydrocarbon group attached to the Schiff base except for the case of methylamine. The fingerprint region, on the other hand, is sensitive to alterations in the Schiff base substituent. Deuterating the Schiff base has a larger effect on the carbon–nitrogen stretching frequency than replacing the Schiff base nitrogen N 14 with N 15 . Furthermore, the data on deuterated Schiff bases indicate that the CCH bending vibrational mode is altered by deuteration. Implications concerning use of these compounds for modelling visual pigments and bacteriorhodopsin are discussed.
One Standard, All Devices (2013)

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Identifying Mutations for MYH‐Associated Polyposis (2010)

Polyposis associated with mutations in the gene MYH is an autosomal recessive syndrome characterized by the development of colorectal adenomas and cancer. Two common mutations, p.Tyr165Cys (exon 7) and p.Glu382Asp (exon 13), have been shown to account for the majority of the mutations occurring in individuals of Caucasian ancestry. Other mutations have been found throughout the gene and many have been shown to have very low frequencies. Ethnic differences in the mutation spectrum have also been observed. Thus, in order to achieve the highest clinical sensitivity, it is necessary to perform whole-gene sequencing of the MYH gene. The sequencing protocol described allows one to identify mutations throughout the MYH gene.
A Novel Prediction-Based Directional Asymmetric Search Algorithm for Fast Block-Matching Motion Estimation (2009)

This paper proposes a very fast block-matching motion estimation algorithm for video compression. This method uses a new concept involving a very compact center-biased characteristic in developing directional asymmetric search patterns, which we refer to as <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">directional</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">asymmetric</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">search</i> (DAS). The initial pattern of the DAS is a compact cross pattern containing only five initial search points. The DAS utilizes error information (block distortions) of the search patterns to determine the search direction, and then asymmetric search patterns are used in the subsequent steps accordingly. Furthermore, a prediction scheme and a best match prejudgment scheme are incorporated to favor fast motion and to benefit stationary and quasi-stationary blocks, respectively. Therefore, the proposed method significantly reduces the number of search points for locating a motion vector. Compared to conventional fast algorithms, the proposed method has the fastest search speed and most satisfactory PSNR values for all test sequences.