gebhart/patrepeval huggingface dataset:
Adenosine prevents TNFα‐induced decrease in endothelial mitochondrial mass via activation of eNOS‐PGC‐1α regulatory axis (664.5) (2014)

To gain insight into the potential role of endothelial mitochondrial function and biogenesis in the preconditioning effects of adenosine (Ado), we incubated human microvascular endothelial cells (HMEC‐1) with TNFα in the presence or absence of Ado. TNFα produced time and dose‐dependent decreases in mitochondrial membrane potential, cellular ATP levels, and mitochondrial mass, which preceded an increase in apoptosis. These effects were prevented by co‐incubation with Ado, an NO donor (detaNO), a guanylate cyclase (GC) activator (YC‐1), or a cell‐permeant cGMP analog (8‐Br‐cGMP). The effects of Ado were blocked by a NO synthase inhibitor (L‐NIO), a soluble guanylate cyclase inhibitor (ODQ), a morpholino antisense oligonucleotide to eNOS, or siRNA knockdown of PGC‐1α. DetaNO reversed the the effect of eNOS knockdown, as did YC‐1 and 8‐Br‐cGMP, while the effect of detaNO was blocked by ODQ. Both detaNO’s and 8‐Br‐cGMP’s effects were prevented by siRNA to PGC‐1α. TNFα also decreased expression of eNOS and PGC‐1α, which was reversed by Ado. DetaNO, but not Ado, rescued expression of PGC‐1α in cells in which eNOS expression was knocked down by eNOS antisense treatment. These results support the existence of an adenosine‐triggered, mito‐and cytoprotective mechanism dependent upon an eNOS‐PGC‐1α regulatory pathway, which acts to preserve endothelial mitochondrial function and mass in the face of inflammatory challenge. Grant Funding Source : Supported by NIH grants: AA014945 &amp; HL095486
Poly(Ferrocenylsilane-block-methacrylate)s via Sequential Anionic and Atom Transfer Radical Polymerization (2006)

The synthesis and characterization of PFS-b-PMMA block copolymers, obtained by a sequential polymerization approach, is described. The poly(ferrocenylsilane) (PFS) block was prepared by anionic polymerization of [l]dimethylsilaferrocenophane, and end-capped using 3-(tert-butyldimethylsiloxy) propyldimethylchlorosilane. Deprotection yielded a 3-hydroxypropyl-terminated PFS which was acylated with 2-bromoisobutyric anhydride. The 2-bromoisobutyryl end-functionalized PFS was used as a macroinitiator for controlled ATRP. Well-defined PFS-b-PMMA block copolymers with low polydispersities (Mw/Mn<1.1) and controlled compositions were obtained.
Dynamic quality-of-service for mobile ad hoc networks (2000)

This paper presents an approach to supporting Quality of Service (QoS) in a dynamic network environment. With this approach, resource reservations represent ranges, and applications adapt to an allocated level of QoS provided by the network at some point within the requested range. To explore this approach, we have implemented a new protocol called dynamic RSVP (dRSVP), which is an extension to RSVP.
Strong quantum squeezing near the pull-in instability of a nonlinear beam (2016)

Microscopic silicon-based suspended mechanical oscillators, constituting an extremely sensitive force probe, transducer, and actuator, are being increasingly employed in many developing microscopies, spectroscopies, and emerging optomechanical and chem-bio sensors. We predict a significant squeezing in the quantum state of motion of an oscillator constrained as a beam and subject to an electrically induced nonlinearity. By taking into account the quantum noise, the underlying nonlinear dynamics is investigated in both the transient and stationary regimes of the driving force leading to the finding that strongly squeezed states are accessible in the vicinity of the pull-in instability of the oscillator. We discuss a possible application of this strong quantum squeezing as an optomechanical method for detecting broad-spectrum single or low-count photons, and further suggest other novel sensing actions.
Comparison of Existing Response Criteria in Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization Using a 3D Quantitative Approach (2015)

The 3D-based imaging biomarkers qEASL and vRECIST were tumor response criteria that could be used to predict patient survival early after initial TACE and enabled clear identification of nonresponders.
Routine determination of biliary lipid composition with the entero-test. (1994)

A simple method for the assay of biliary lipids was used for routine determination of biliary cholesterol saturation index (CSI) in 17 healthy subjects, 40 untreated patients with radiolucent gallstones and 21 gallstone patients treated with ursodiol. The method is based on collection of bile with the Entero-Test, a device for easy sampling of gastrointestinal contents. The procedure was easy to perform and well accepted by the patients. Both CSI and the cholesterol content of bile were higher in untreated gallstone patients than in controls, and were significantly lower in treated than in untreated patients. Normal CSI was found in 35% of untreated gallstone patients, while 24% of healthy subjects had supersaturated bile. Supersaturated bile was still present in 14% of ursodeoxycholic acid treated patients, suggesting inefficacy of therapy. These results demonstrate the possibility of performing easy, routine determination of biliary lipid composition, which can yield useful information for the management of gallstone patients.
Loss of longitudinal coherence as a result of the birefringence effect (1987)

The longitudinal coherence properties of waves propagating through a birefringent optical fiber are described theoretically and experimentally. A significant loss of longitudinal coherence is clearly observed for interference between two orthogonally polarized HE11 modes traversing an optical fiber with highly stress-induced anisotropy. It is verified that coherence degradation is due to the difference in magnitude of the chromatic-dispersion difference between the two eigenpolarization modes, even when the optical-path difference between the two polarizations is zero. The theoretically predicted results closely match experimentally obtained results with respect to both the modulus of the longitudinal coherence and its curved shape against the optical-path difference in the wavelength region from 0.8 to 1.55 μm.
Dust seed formation using an adjustable multi-magnetron gas aggregation source (2017)

Nanocosmos Interstellar Dust Meeting, Toulouse, France 12-13 june 2017. -- https://epolm3-nanocosm.sciencesconf.org/resource/page/id/7
Comparison of Egg Testing Devices for Internal Egg Quality Measurements (2016)

본 실험은 국내 외에서 시판 중인 계란검사장비 3종인 레이저형, 탕침형 그리고 초음파형의 성능을 평가하고자 실시하였다. 실험에 사용한 신선란은 단일 계군에서 산란한 특란을 선발하여 사용하였다. 실험 1에서는 동일한 계란을 순차적으로 3종의 장비를 이용하여 분석하였다. 실험 2에서는 동일한 계란을 순차적으로 2종의 장비를 이용하여 분석하였으며, 실험 3에서는 동일한 계군에서 산란한 계란 200씩을 각각의 할란검사장비를 이용하여 난질을 분석하였다. 분석항목으로는 난중, 농후난백높이, 호우유닛 그리고 난황색을 측정하였다. 실험 1과 2에서는 장비에 따른 난중의 차이는 발견되지 않았지만, 농후난백 높이와 호우유닛의 수치가 초음파형에서 가장 높았으며, 그 다음으로 탕침형, 레이저형순으로 조사되었다. 동일한 계군에서 산란한 계란을 각각 할란검사장비를 이용하여 분석한 결과, 난중에서는 차이가 없었지만, 초음파형에서 가장 높은 난백고와 호우유닛을 나타내었다. 하지만 난황색은 레이저형에서 가장 높은 결과를 나타내었다. 결론적으로 신선란을 대상으로 조사한 할란검사장비의 난질평가 결과는 장비에 따른 차이가 있는 것으로 조사되었다. 비록 장비간의 상관계수는 높게 계산되었지만, 동일 계란에 따른 호우유닛 결과는 장비에 따른 편의(bias)와 넓은 신뢰한계를 나타내었다. 이러한 결과는 호우유닛이 높은 신선란을 대상으로 품질을 평가한다면 어떤 장비를 사용하더라도 계란의 품질 등급에는 차이가 없겠지만, 일정기간 저장되어 호우유닛이 떨어진 계란을 대상으로 품질을 평가한다면 장비에 따라서 계란 등급에 차이가 날 수 있는 것을 의미한다. 하지만 본 연구에서는 동일한 계란을 할란 후 순차적으로 측정하여, 난황과 난백 시료 이동에 따른 기계적인 오차를 고려할 수 없기 때문에 향후 이러한 방법을 보완하여 할란검사장비의 성능을 평가할 수 있는 기법의 개발이 필요하겠다. This study was conducted to compare three commercially available egg testing devices for measuring egg quality. The devices used were a Laser-type (automatic), a Ultrasonic-type (automatic), and a Probe-type (manual). Fresh eggs weighing 60~68 grams were obtained from a commercial hen farm. Three trials were conducted. In Trial 1, a total of 50 eggs were successively analyzed by the three egg testing devices. In Trial 2, fresh eggs were successively analyzed by a combination of two egg testing devices. In Trial 3, a total of 600 eggs (weighing 60~68 grams) laid by same flock were selected, further divided into three sub-groups with a total of 200 eggs, and analyzed by an egg testing device. In Trials 1 and 2, no apparent difference was observed in egg weight between egg testing devices. However, albumin height was scored highest in the Ultrasonic-type egg tester followed by the Probe-type and Laser-type (Trials 1 and 2). Consequently, the Haugh unit was similarly altered. Yolk color was highest in the Laser-type egg tester followed by the Ultrasonic-type and Probe-type (Trials 1 and 2). When fresh eggs laid by a single flock were independently analyzed by three devices, egg weight did not differ, but albumin height and Haugh unit were higher (p<0.05) in the Ultrasonic-type egg tester than in the Probe-type or Laser-type testers. However, Laser-type testers produced higher (p<0.05) yolk color values than the Ultrasonic-type or Probe-type egg testers. In conclusion, the commercially available egg testing devices exhibited performance differences in measuring egg qualities, which warrants further consideration as to whether the magnitude of bias and precision between the devices could be acceptable in the egg grading system, especially when assessing eggs stored for certain durations.
PEDIATRIC SLEEP MEDICINE (2007)

Account Register Activate Subscription Help Subscribe American Academy of Neurology Login Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Journal logo Issues Current IssueBack Issues CollectionsMedia Continuum AudioVideo Gallery CMEAbout About ContinuumAbout Continuum AudioSubscription Details and AccessEditorial BoardEditorial and Publishing ContactsInformation for AuthorsAAN/WFN Continuum EducationAbout AANRights and PermissionsReprints
Microwave plasma-assisted chemical vapor deposition of microcrystalline diamond films via graphite etching under different hydrogen flow rates (2019)

The growth of microcrystalline diamond films with different hydrogen flow rates <italic>via</italic> etching graphite as the carbon source was studied.
A set of hard spheres with tangential inelastic collision as a model of granular matter: $1/f^\alpha$ fluctuation, non-Gaussian distribution, and convective motion (1995)

A set of hard spheres with tangential inelastic collision is found to reproduce observations of real and numerical granular matter. After time is scaled so as to cancel energy dissipation due to inelastic collisions out, inelastically colliding hard spheres in two dimensional space come to have 1=f ff fluctuation of total energy, non-Gaussian distribution of displacement vectors, and convective motion of spheres, which hard spheres with elastic collision, a conventional model of granular matter, cannot reproduce. 83.70.Fn, 52.25.Gj, 47.27.-i, 51.30.+i Typeset using REVT E X Granular matter attracted attention of physicists recently [1]. It exhibits many strange behaviors: segregation [2], surface standing wave [3], bubbling [4], 1=f ff fluctuation [5], convection [6], non-Gaussian distribution [7,8], and turbulence [7,9]. Although numerical simulations easily reproduce most of them, we cannot understand their mechanisms. This is because we do not have any universal model which ca...
Editorial Comment (2009)

No AccessJournal of UrologyAdult Urology1 Mar 2009Editorial Comment George J. Netto George J. NettoGeorge J. Netto More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2008.10.221AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 181(3), pp. 1074–1075 References 1 : Prostate needle biopsies containing prostatic intraepithelial neoplasia or atypical foci suspicious for carcinoma: implications for patient care. J Urol2006; 175: 820. Link, Google Scholar 2 : High-grade prostatic intraepithelial neoplasia in needle biopsy as risk factor for detection of adenocarcinoma: current level of risk in screening population. Urology2005; 65: 538. Google Scholar Department of Pathology, Johns Hopkins University, Baltimore, Maryland© 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 3March 2009Page: 1074-1075 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information George J. Netto More articles by this author Expand All Advertisement PDF downloadLoading ...
FluorescentJ-type Aggregates and Thermotropic Columnar Mesophases of Perylene Bisimide Dyes (2001)

A series of perylene tetracarboxylic acid bisimides 3a-e bearing 3,4,5-tridodecyloxyphenyl substituents on the imide N atoms and zero, two, or four phenoxy-type substituents in the bay positions of the perylene core were synthesized. From investigations of their spectroscopic properties and aggregation behavior in low-polarity solvents by absorption and fluorescence optical spectroscopy, not only were these compounds found to form fluorescent J-type aggregates, but also binding constants for aggregation could be derived which reflect the number and steric demand of the phenoxy substituents for bisimides 3a-d. In the pristine state, 3a-d form thermotropic hexagonal columnar mesophases which exist over a broad temperature range from below -30 degrees C to over 300 degrees C. For the tetraphenoxy-substituted compound 3e, however, a layered crystalline structure was found. This difference in behavior can be explained by the concept of microphase segregation of the aromatic cores of the molecules and the alkyl chains at the periphery. The high stability and bright fluorescence of the mesophase of several of the compounds make them promising for applications as polarizers or components in (opto)electronic devices.
Evaluation of the TV Customer Experience Using Eye Tracking Technology (2018)

As the TV experience evolves to provide customers with a richer, more interactive experience across multiple devices, it is increasingly important to make the best use of subjective and objective techniques to inform the development of TV user interfaces. This paper describes the design of a new experiment to evaluate the TV customer experience using eye tracking technology, focused on the BT Player, a visually-rich Video-on-Demand application. Eye tracking provides an objective assessment which does not interfere with the natural interaction of the user with the system. The evaluation will capture a unique data set through the observation of test subjects exposed to a prioritised set of test conditions presented within a controlled environment. The paper presents the design of the experiments, including requirements capture, hardware and software setup, experimental protocol, data collection and analysis. The paper also outlines the challenges posed by the dynamic nature of the content and user interaction with the TV interface.
Monoclonal Antibodies Against Human BAP31 for Immunocytochemistry (2009)

Human BAP31 is a 28 kDa polytopic integral protein of the ER and part of a large BAP hetero-oligomeric complex that includes the related BAP29 protein and connections to actomyosin. BAP31 interacts with mIgD, cellubrevin, major histocompatibility complex class I, and BCL-2/BCL-XL, and plays an important role in regulating the egress of these proteins and in apoptosis. Northern blot analyses have revealed BAP31 RNA transcripts in many tissues, including thymus, spleen, brain, kidney, testis, liver, and lung. However, prominent BAP31 protein expression analyzed by immunohistochemistry is restricted to a minority of cells in normal human tissue. Further studies should be made to verify the expression profiles of BAP31 in the protein level. Production of high affinity MAbs suitable for immunohistochemical staining has lagged. Here we generate a set of MAbs that could be used in Western blot, immunoprecipitation, and immunocytochemistry, providing a new powerful tool for investigation of expression profile of BAP31 protein and furthers the study of BAP31 functions.
Cembrane and pseudopterane diterpenes from the soft coral Gersemia rubiformis (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCembrane and pseudopterane diterpenes from the soft coral Gersemia rubiformisDavid Williams, Raymond J. Andersen, Gregory D. Van Duyne, and Jon ClardyCite this: J. Org. Chem. 1987, 52, 3, 332–335Publication Date (Print):February 1, 1987Publication History Published online1 May 2002Published inissue 1 February 1987https://pubs.acs.org/doi/10.1021/jo00379a002https://doi.org/10.1021/jo00379a002research-articleACS PublicationsRequest reuse permissionsArticle Views317Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib (2014)

Dabrafenib plus trametinib, as compared with vemurafenib monotherapy, significantly improved overall survival in previously untreated patients with metastatic melanoma with BRAF V600E or V600K mutations, without increased overall toxicity. (Funded by GlaxoSmithKline; ClinicalTrials.gov number, NCT01597908.).
Allergens, dysbiosis and immune dysregulation: case studies on inflammatory bowel disease. (2003)

Inflammatory bowel disease (IBD) is a general term for a group of chronic inflammatory disorders of the bowel, usually divided into two major categories: Crohn’s disease (CD) and ulcerative colitis (UC). Crohn’s disease most commonly affects the distal ileum and colon, but may occur in any part of the gastrointestinal (GI) tract. Ulcerative colitis is limited to the colon. The two disease categories may present with similar symptoms of frequent diarrhea associated with abdominal pain, cramping, and fever. Blood in the stool is more characteristic of UC although it may sometimes be seen in patients with CD. The prevalence of IBD in the United States is approximately 100 cases per 100,000 population. 1
Low Testosterone Concentrations and Prediction of Future Heart Failure in Men and in Women: Evidence from the Large FINRISK97 Study (2021)

Low levels of testosterone do not independently predict future heart failure.
Oligonucleotide-Mediated, PCR-Independent Cloning by Homologous Recombination (2001)

We have developed an oligonucleotide-mediated cloning technique based on homologous recombination in Saccharomyces cerevisiae that allows precise DNA sequences to be transferred independent of restriction enzymes and PCR. In this procedure, linear DNA sequences are targeted to a chosen site in a yeast vector by DNA linkers, which consist of two partially overlapping oligonucleotides. The linkers contain relatively short regions of both yeast vector sequences and insert sequences, which stimulate homologous recombination between the vector and the insert. The linkers can also contain sequences not found in either the vector or the insert (e.g., sequences that encode ribosome binding sites, epitope tags, preferred codons, etc.), thus allowing modification of the transferred DNA. Linkers can be designed such that DNA sequences can be transferred with just two reusable universal oligonucleotides and two gene-specific oligonucleotides. This cloning method, which is performed by co-transforming yeast with linear vector, substrate DNA, and unannealed oligonucleotides, has been termed the yeast-based, oligonucleotide-mediated gap repair technique (YOGRT).
Localization of secretory mucins MUC5AC and MUC5B in normal/healthy human airways (2021)

Rationale: MUC5AC and MUC5B are the predominant gel-forming mucins in the mucus layer of human airways. Each mucin has distinct functions and site-specific expression. However, the regional distribution of expression and cell types that secrete each mucin in normal/healthy human airways are not fully understood. Objectives: To characterize the regional distribution of MUC5B and MUC5AC in normal/healthy human airways and assess which cell types produce these mucins, referenced to the club cell secretory protein (CCSP). Methods: Multiple airway regions from 16 nonsmoker lungs without a history of lung disease were studied. MUC5AC, MUC5B, and CCSP expression/colocalization were assessed by RNA in situ hybridization and immunohistochemistry in five lungs with histologically healthy airways. Droplet digital PCR and cell cultures were performed for absolute quantification of MUC5AC/5B ratios and protein secretion, respectively. Measurements and Main Results: Submucosal glands expressed MUC5B, but not MUC5AC. However, MUC5B was also extensively expressed in superficial epithelia throughout the airways except for the terminal bronchioles. Morphometric calculations revealed that the distal airway superficial epithelium was the predominant site for MUC5B expression, whereas MUC5AC expression was concentrated in proximal, cartilaginous airways. RNA in situ hybridization revealed MUC5AC and MUC5B were colocalized with CCSP-positive secretory cells in proximal superficial epithelia, whereas MUC5B and CCSP-copositive cells dominated distal regions. Conclusions: In normal/healthy human airways, MUC5B is the dominant secretory mucin in the superficial epithelium and glands, with distal airways being a major site of expression. MUC5B and MUC5AC expression is a property of CCSP-positive secretory cells in superficial airway epithelia.
Application of Urethane Prepolymers to Immobilization of Biocatalysts: Δ1Dehydrogenation of Hydrocortisone byArthrobacter simplexCells Entrapped with Urethane Prepolymers (1980)

Journal Article Application of Urethane Prepolymers to Immobilization of Biocatalysts: Δ1Dehydrogenation of Hydrocortisone by Arthrobacter simplex Cells Entrapped with Urethane Prepolymers Get access Kenji Sonomoto, Kenji Sonomoto Laboratory of Industrial Biochemistry, Department of Industrial Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Ing-Nyol Jin, Ing-Nyol Jin Laboratory of Industrial Biochemistry, Department of Industrial Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606, Japan Present address: Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Kyung Pook National University, Taegu 635, Korea. Search for other works by this author on: Oxford Academic Google Scholar Atsuo Tanaka, Atsuo Tanaka Laboratory of Industrial Biochemistry, Department of Industrial Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Saburo Fukui Saburo Fukui Laboratory of Industrial Biochemistry, Department of Industrial Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 44, Issue 5, 1 May 1980, Pages 1119–1126, https://doi.org/10.1080/00021369.1980.10864090 Published: 01 May 1980 Article history Received: 29 October 1979 Published: 01 May 1980