gebhart/patrepeval huggingface dataset:
Hemodynamic Changes During Resuscitation After Burns Using the Parkland Formula (2009)

Preload variables, global systolic function, and oxygen transport recorded simultaneously by three separate methods showed no need to increase the total fluid volume within 36 hours of a major burn. Early (12 hours) signs of central circulatory hypovolemia, however, support more rapid infusion of fluid at the beginning of treatment.
The [3H]Tryptamine Receptor in Human Brain: Kinetics, Distribution, and Pharmacologic Profile (1994)

The kinetics and distribution of [3H]tryptamine binding sites in human brain were investigated. Specific [3H]tryptamine binding in frontal cortex was of nanomolar affinity, reversible, saturable, and best fit to a single-site model. A heterogeneous distribution for this binding site was demonstrated, with the highest density observed in hippocampus, thalamus >> caudate nucleus, frontal cortex, pons, temporal cortex > globus pallidus/putamen, cerebellum. The similarities in kinetics and distribution of the [3H]tryptamine binding site in human and rat brain indicate that these two binding sites represent homologous structures. However, the present displacement studies using various ligands (indoleamines and other tryptophan metabolites, phenylethylamines, and miscellaneous drugs) and salts (Na+, K+, Ca2+, Mg2+, Cu2+) indicate stereospecific displacement as well as a rank-order potency profile that is different from that reported for the rat [3H]tryptamine binding site. This suggests the presence of distinct species-dependent [3H]tryptamine binding site subtypes. Taken together with the documented electrophysiological and behavioral evidence of tryptamine-mediated effects in the rat and the recent report of a significant loss of these binding sites in human portal systemic encephalopathy, as well as the present demonstration of an effect of guanine nucleotides on [3H]-tryptamine binding affinity, these findings suggest that these binding sites might be functional receptors. The implied role of tryptamine in neuropsychiatric disorders is supported by this demonstration of a receptor for [3H]-tryptamine in human brain.
Room-temperature operation of a para-H2 rotational Raman laser (1985)

We have successfully demonstrated high-power operation of a para-H2 rotational Raman laser at room temperature. A photon conversion efficiency of 60% was obtained with a 10.6-μm CO2 pump energy of 4.3 J, giving 0.85 J in the first Stokes pulse at 17.0 μm. Transient effects observed under room-temperature conditions are also reported.
Molecular properties of lupin and serradella leghaemoglobins (1972)

1. Leghaemoglobins were extracted from the root nodules of lupin (Lupinus luteus L.) and serradella (Ornithopus sativus Brot.) plants and fractionated into different leghaemoglobin components on DEAE-cellulose-acetate columns. 2. The first two fractions eluted from columns loaded with either lupin or serradella leghaemoglobins were in the Fe(3+) oxidation state. 3. These components have protohaem IX as the prosthetic group and glycine as the N-terminal amino acid. 4. Other properties are: lupin component I, pI5.08, molecular weight 19000; lupin component II, pI5.13, molecular weight 20600; serradella component I, pI5.00, molecular weight 17500; serradella component II, pI5.05, molecular weight 19100. 5. Leghaemoglobins are thus heterogeneous with respect to size and charge.
Bendamustine Associated with Irreversible Ascending Paralysis (2013)

Bendamustine is an alkylating agent currently used in the treatment of lymphoproliferative disorders. Many adverse effects, including a rare case of reversible neurotoxicity, have been reported in association with bendamustine. Herein, we report the first case of irreversible ascending paralysis related to bendamustine.
Photochemical Deposition of ZnS from the Gas Phase and Simultaneous Luminescence Detection of Photofragments from a Single-Source Precursor, Zn(S2COCHMe2)2 (1997)

ZnS thin films are made by laser driven chemical vapor deposition (CVD) from a single-source precursor, Zn(S2COCHMe2)2 under vacuum conditions. Photofragments in the gas phase are identified simultaneously by luminescence spectroscopy. The laser selectively activates the initial decomposition of the precursor and drives its conversion to the desired materials under mild conditions. These photolytically produced films are compared to films made by thermal deposition from the same precursor. The deposits from both techniques, characterized by X-ray diffraction, Rutherford backscattering, and X-ray photoelectron spectroscopy, are pure stoichiometric ZnS in the hexagonal phase. Surface morphology differs in shape and granule size. During the laser-driven CVD process, gas-phase photochemical intermediates are identified by luminescence spectroscopy. The luminescent photoproducts are Zn and S2, the two elemental components of the final material. Photofragmentation mechanisms leading to ZnS, the luminescent species Zn and S2, and the gaseous organic byproducts are discussed. Further characterization of the photofragmentation pathways is provided by the trapping of the photoreaction products and by mass spectroscopy.
Undistorting Foreground Objects in Wide Angle Images (2013)

The use of wide angle lens on commodity cameras are becoming increasingly popular. However, this leads to image distortions due to the large difference in relative orientation of the different foreground objects with respect to the camera's image plane. More importantly, these distortions are different in different parts of the image since it depends entirely on the position and orientation of the foreground object with respect to the image plane. Such distortions often manifest themselves as objects in the foreground appearing fatter than they are supposed to be or parts thereof (e.g. hands or head of people) looking disproportionately larger than the rest of them. Though there are earlier works addressing other common distortions in cameras like radial distortions, little attention has been given to this problem. In this paper, we present an effective method to remove such distortions in foreground objects minimally distorting the background. This is achieved efficiently using a mesh-based pixel displacement technique assisted by a simple and intuitive user interface design.
A power efficient 3-Gbits/s 1.8V PMOS-based LVDS output driver (2012)

This paper presents a new topology of a PMOS based LVDS voltage-mode output driver. This topology is designed to meet the requirements of low power consumption and high data rates applications. The driver, which consists of a pre-driver stage and an output stage, uses a positive feedback technique at the output stage to achieve line impedance matching and power saving. The pre-driver stage is used to set the driver's swing and common mode output voltage. The pre-driver and the output stage consume only 9mW of power at 3 Gbps speed while operating from a 1.8V voltage supply. The system is designed and simulated using CMOS 180nm technology and is fully compliant with LVDS output swing and common mode voltage specifications.
Molecular Determinants of Lung Development (2013)

Development of the pulmonary system is essential for terrestrial life. The molecular pathways that regulate this complex process are beginning to be defined, and such knowledge is critical to our understanding of congenital and acquired lung diseases. A recent workshop was convened by the National Heart, Lung, and Blood Institute to discuss the developmental principles that regulate the formation of the pulmonary system. Emerging evidence suggests that key developmental pathways not only regulate proper formation of the pulmonary system but are also reactivated upon postnatal injury and repair and in the pathogenesis of human lung diseases. Molecular understanding of early lung development has also led to new advances in areas such as generation of lung epithelium from pluripotent stem cells. The workshop was organized into four different topics, including early lung cell fate and morphogenesis, mechanisms of lung cell differentiation, tissue interactions in lung development, and environmental impact on early lung development. Critical points were raised, including the importance of epigenetic regulation of lung gene expression, the dearth of knowledge on important mesenchymal lineages within the lung, and the interaction between the developing pulmonary and cardiovascular system. This manuscript describes the summary of the discussion along with general recommendations to overcome the gaps in knowledge in lung developmental biology.
A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis (2011)

Our results add to the evidence that a channelopathy contributes to cerebellar dysfunction in MS. Our data suggest that Nav1.8-specific blockers, when available for humans, merit study in MS.
Differences in susceptibility of Arabidopsis ecotypes to crown gall disease may result from a deficiency in T-DNA integration. (1997)

We show that among ecotypes of Arabidopsis, there is considerable variation in their susceptibility to crown gall disease. Differences in susceptibility are heritable and, in one ecotype, segregate as a single major contributing locus. In several ecotypes, recalcitrance to tumorigenesis results from decreased binding of Agrobacterium to inoculated root explants. The recalcitrance of another ecotype occurs at a late step in T-DNA transfer. Transient expression of a T-DNA-encoded beta-glucuronidase gusA gene is efficient, but the ecotype is deficient in crown gall tumorigenesis, transformation to kanamycin resistance, and stable GUS expression. This ecotype is also more sensitive to gamma radiation than is a susceptible ecotype. DNA gel blot analysis showed that after infection by Agrobacterium, less T-DNA was integrated into the genome of the recalcitrant ecotype than was integrated into the genome of a highly susceptible ecotype.
Brown adipose tissue in young adults who were born preterm or small for gestational age (2018)

Young adults born extremely preterm or SGA show BAT development similar to those born full term at a normal birth weight. Thus, the increased risk of cardiovascular and metabolic disorders in these groups is not due to the absence of BAT, although our results do not exclude possible BAT involvement in this scenario. Larger studies are needed to understand these relationships.
The racemization of sulfonium salts. II. The racemization of substituted benzylethylmethylsulfonium perchlorates (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe racemization of sulfonium salts. II. The racemization of substituted benzylethylmethylsulfonium perchloratesDavid Darwish, Sai Hong Hui, and Ralph TomilsonCite this: J. Am. Chem. Soc. 1968, 90, 20, 5631–5632Publication Date (Print):September 1, 1968Publication History Published online1 May 2002Published inissue 1 September 1968https://pubs.acs.org/doi/10.1021/ja01022a069https://doi.org/10.1021/ja01022a069research-articleACS PublicationsRequest reuse permissionsArticle Views115Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spectroscopy, molecular structure, and electropolymerization of Ni(ii) and Cu(ii) complexes containing a thiophene-appending fluorinated Schiff base ligand (2023)

In this contribution, we describe the preparation, characterization, and electrochemical behavior of a series of four new mononuclear M(II) complexes featuring a symmetric substituted N<sub>2</sub>O<sub>2</sub>-tetradentate Schiff base ligand, bearing either trifluoromethyl and <i>p</i>-bromophenyl (M = Ni, 3; Cu, 4) or trifluoromethyl and the π-extended <i>p</i>-(2-thienyl)phenylene (M = Ni, 5; Cu, 6) substituents. Complexes 3 and 4 were readily synthesized by reacting the diprotic fluorinated Schiff base proligand 2 with the appropriate hydrated metal(II) acetates, whereas 5 and 6 were obtained upon Stille cross-coupling reaction of 3 and 4 with 2-(tributylstannyl)-thiophene, respectively. Compounds 3-6 were isolated as neutral, air, and thermally stable-coloured solids, with yields ranging from 60 to 80%. The four complexes, the diimine precursor 1 and its trifluoroacetylated derivative 2, were identified using analytical (EA, ESI-MS), spectroscopic (IR, <sup>1</sup>H, <sup>13</sup>C, and <sup>19</sup>F NMR), and X-ray crystallographic methods. X-ray crystal structure determination of complexes 3-5 revealed that both four-coordinate Ni(II) and Cu(II) metal ions adopt a square planar geometry. The magnetic properties of powdered samples of the Cu(II) derivatives 4 and 6 have been investigated (2-300 K) and found consistent in both cases with a single isolated copper(II) ion (<i>s</i> = 1/2). DFT calculations were used to examine the optimal geometries of complexes 5 and 6, allowing for a consistent perspective of their structure and characteristics. The primary aspects of the UV-vis spectra were interpreted using TD-DFT computations. Finally, electrochemical data indicate that complexes 5 and 6 polymerize at high anodic potentials in acetonitrile (greater than 2.0 V <i>vs.</i> Ag/AgCl). Cyclic voltammetry, scanning electron microscopy, and energy-dispersive X-ray spectroscopy (SEM-EDS) analyses were used to characterize the obtained films poly-5 and poly-6.
Multiple Staphylococcal Cassette Chromosomes and Allelic Variants of Cassette Chromosome Recombinases in Staphylococcus aureus and Coagulase-Negative Staphylococci from Norway (2007)

We investigated the nature of the staphylococcal cassette chromosome mec (SCCmec) elements and cognate insertion sites in a collection of 42 clinical staphylococcal isolates of various species from Norway. The ccr and mec genes and the attachment sites (attL/attR) were identified by PCR, Southern blot hybridization, and DNA sequencing. We found 10 possibly new SCCmec types and one previously unreported variant of SCCmec type III (mec complex A, ccrAB3, and ccrC7) in Staphylococcus epidermidis, Staphylococcus haemolyticus, and Staphylococcus hominis. Eleven of 42 strains contained multiple copies of ccr, suggesting the presence of mosaic structures composed of multiple SCC elements. S. haemolyticus contained ccrAB2 genes identical to those in S. aureus SCCmec type IV but lacked IS1272 and mec regulators. Two new allelic ccr variants, ccrC6 and ccrC7, were identified. Also, the presumed functional version of ccrB1 was found in a mecA-positive S. hominis strain and in mecA-negative S. epidermidis and S. hominis strains. Only minor differences in direct repeats in the left and right boundaries (attR/attL) were observed, while there was more variation in the inverted repeats. Coagulase-negative staphylococci (CoNS) contained several representatives of different ccr complexes and thus seemed to harbor multiple or composite new types of SCCmec. The enormous diversity observed in the SCCmec elements implies a large SCCmec reservoir in CoNS.
Isolation and Characterization of Sweat Gland Myoepithelial Cells from Human Skin (2014)

Stem cells routinely maintain the main epidermal components, i.e. the interfollicular epidermis, hair follicles, and sweat glands. Human sweat glands present throughout the body are glandular exocrine organs that mainly play a role in thermoregulation by sweating. Emerging evidence points to the presence of stem cells in sweat glands, but it remains unclear whether such stem cells exist in human sweat glands. Here, we attempted to gather evidence for stem cells in human sweat glands, which would be characterized by self-renewal ability and multipotency. First, we explored human sweat gland cells for expression of stem cell markers. CD29 and Notch, epidermal stem cell markers, were found to reside among α-smooth muscle actin-positive myoepithelial cells in human sweat glands. Next, sweat gland myoepithelial cells were isolated from human skin as a CD29(hi)CD49f (hi) subpopulation. The myoepithelial cell-enriched CD29(hi)CD49f (hi) subpopulation possessed the ability to differentiate into sweat gland luminal cells in sphere-forming assays. Furthermore, CD29(hi)CD49f (hi) subpopulation-derived sphere-forming cells exhibited long-term proliferative potential upon multiple passaging, indicating that the CD29(hi)CD49f (hi) myoepithelial subpopulation includes stem cells with self-renewal ability. These findings provide evidence that human sweat gland myoepithelial cells contain stem cells that possess both self-renewal ability and multipotency to differentiate into sweat glands.
Demonstration of low power penalty of silicon Mach–Zehnder modulator in long-haul transmission (2012)

We demonstrate error-free 80km transmission by a silicon carrier-depletion Mach-Zehnder modulator at 10Gbps and the power penalty is as low as 1.15dB. The devices were evaluated through the bit-error-rate characterizations under the system-level analysis. The silicon Mach-Zehnder modulator was also analyzed comparatively with a lithium niobate Mach-Zehnder modulator in back-to-back transmission and long-haul transmission, respectively, and verified the negative chirp parameter of the silicon modulator through the experiment. The result of low power penalty indicates a practical application for the silicon modulator in the middle- or long-distance transmission systems.
Determination of human energy generated by skeletal muscle (2002)

In order to analyse the mechanical interaction between human arm and manual control device for the design of optimized physical man-machine interfaces, a method of determination of energy expenditure by the muscle system of a human arm acting on the device is presented. This energy is considered as a physical and measurable quantity, and can be used to evaluate the performance of a mechanical man-machine interface. For this, a musculo-mechanical model of the human arm is described for the determination of muscle energy. An example of human joint torques and energy calculation applied to a 2D biomechanical human arm suitable for simulation purpose is analytically given.
Identification and characterization of two nonessential regions of the rabbitpox virus genome involved in virulence (1991)

We have developed a means to identify genes associated with particular aspects of virulence. By beginning with an avirulent deletion mutant of rabbitpox virus and systematically reintroducing overlapping segments of the deleted region, we have identified two regions of the viral genome associated with increased virulence in mice. Evaluation of illness has been aided by the exploitation of weight loss as an indicator of pathogenesis. One of the regions identified by this method contains several open reading frames and includes two previously described genes. A third, as yet undescribed, gene within this region potentially encodes a product related to the C5 protein of human complement. The second region of DNA associated with increased virulence is the HindIII M fragment, which contains only one complete open reading frame. Analysis of this previously unreported gene shows coding potential for a polypeptide of 254 amino acids (approximately 25 kDa) which is related to the C4 component of human complement. The elucidation of two new viral genes related to complement components, taken together with the recent report of the biological activity of a poxvirus-encoded complement-binding protein, suggests the importance of interactions of the virus with the complement system during a normal infection.
5b,7b-Diaza-3b,9b-diborabenzo[  ghi  ]perylenes (2010)

Treatment of a precursor to the chelating Lewis acid 2,2′-diborabiphenyl with 2,6-bisalkynyl-substituted pyridazines, leads to elimination of 2 equiv. of ClSiMe 3 ; subsequent treatment of the mixture with PtCl 2 catalyzes the cyclization of observable intermediates to the title 5b,7b-diaza-3b,9b-diborabenzo[ghi]perylene compounds in low isolated yields. The compounds were characterized by NMR and UV–vis spectroscopies, and in one case, by X-ray crystallography. NICS(1) computations indicate that the inner ring is less aromatic than the outer rings.
Haptic Human-Human Interaction During an Ankle Tracking Task: Effects of Virtual Connection Stiffness (2023)

&lt;p&gt;While treating sensorimotor impairments, a therapist may provide physical assistance by guiding their patient's limb to teach a desired movement. In this scenario, a key aspect is the compliance of the interaction, as the therapist can provide subtle cues or impose a movement as demonstration. One approach to studying these interactions involves haptically connecting two individuals through robotic interfaces. Upper-limb studies have shown that pairs of connected individuals estimate one another's goals during tracking tasks by exchanging haptic information, resulting in improved performance dependent on the ability of one's partner and the stiffness of the virtual connection. In this study, our goal was to investigate whether these findings generalize to the lower-limb during an ankle tracking task. Pairs of healthy participants (i.e., dyads) independently tracked target trajectories with and without connections rendered between two ankle robots. We tested the effects of connection stiffness as well as visual noise to manipulate the correlation of tracking errors between partners. In our analysis, we compared changes in task performance across conditions while tracking with and without the connection. We found that tracking improvements while connected increased with connection stiffness, favoring the worse partner in the dyad during hard connections. We modeled the interaction as three springs in series, considering the stiffness of the connection and each partners' ankle, to show that improvements were likely due to a cancellation of random tracking errors between partners. These results suggest a simplified mechanism of improvements compared to what has been reported during upper-limb dyadic tracking.&lt;/p&gt;
Hierarchical Bayesian models for inverse problems in heat conduction (2004)

Stochastic inverse problems in heat conduction with consideration of uncertainties in the measured temperature data, temperature sensor locations and thermophysical properties are addressed using a Bayesian statistical inference method. Both parameter estimation and thermal history reconstruction problems, including boundary heat flux and heat source reconstruction, are studied. Probabilistic specification of the unknown variables is deduced from temperature measurements. Hierarchical Bayesian models are adopted to relax the prior assumptions on the unknowns. The use of a hierarchical Bayesian method for automatic selection of the regularization parameter in the function estimation inverse problem is discussed. In addition, the method explores the length scales in the estimation of thermal variables varying in space and time. Markov chain Monte Carlo (MCMC) simulation is conducted to explore the high dimensional posterior state space. The methodologies presented are general and applicable to a number of data-driven engineering inverse problems.