gebhart/patrepeval huggingface dataset:
Torquability of microcatheter guidewires: the resulting torsional moment. (2000)

Guidewires for microcatheters used for the subselective catheterization of small vessels must meet high quality requirements in regard to handling, steerability, radiopacity and physical properties. The aim of this paper is to classify one of the factors that determine the physical and mechanical parameters of a number of existing microcatheter guidewires. A torsion-testing equipment for guidewires was devised. Nitinol wires were tested and compared with the austenitic stainless steel variants. 13 different commercial wires were tested. Tensile strength, shear modulus and wire diameter are the determining factors of the torsional rigidity of guidewires. By interpreting the measured torsional momentums various statements concerning the torsional rigidity of different wires can be made. The properties of guidewires are characteristic features of a system and friction and flexible strength examinations have to be carried out to design new variants of wires to meet the requirements of interventional physicians.
Safety and performance of the third-generation drug-eluting resorbable coronary magnesium scaffold system in the treatment of subjects with de novo coronary artery lesions: 6-month results of the prospective, multicenter BIOMAG-I first-in-human study (2023)

This study was funded by BIOTRONIK AG.
Combining peptide recognition specificity and context information for the prediction of the 14‐3‐3‐mediated interactome in S. cerevisiae and H. sapiens (2010)

Large-scale interaction studies contribute the largest fraction of protein interactions information in databases. However, co-purification of non-specific or indirect ligands, often results in data sets that are affected by a considerable number of false positives. For the fraction of interactions mediated by short linear peptides, we present here a combined experimental and computational strategy for ranking the reliability of the inferred partners. We apply this strategy to the family of 14-3-3 domains. We have first characterized the recognition specificity of this domain family, largely confirming the results of previous analyses, while revealing new features of the preferred sequence context of 14-3-3 phospho-peptide partners. Notably, a proline next to the carboxy side of the phospho-amino acid functions as a potent inhibitor of 14-3-3 binding. The position-specific information about residue preference was encoded in a scoring matrix and two regular expressions. The integration of these three features in a single predictive model outperforms publicly available prediction tools. Next we have combined, by a naïve Bayesian approach, these "peptide features" with "protein features", such as protein co-expression and co-localization. Our approach provides an orthogonal reliability assessment and maps with high confidence the 14-3-3 peptide target on the partner proteins.
Topology-Preserving Deformations of Fuzzy Digital Pictures (2000)

This chapter considers the topology of two-dimensional fuzzy digital pictures, and discusses topology-preserving deformations of these fuzzy pictures that generalize deformations of two-valued digital pictures. It is shown that an arbitrary fuzzy picture can be transformed by this type of deformation into a coherent fuzzy picture. As another application, it is shown that the genus of a fuzzy picture is a linear combination of local property values.
The Simulation of T-F Short-Circuit Fault Location in All Parallel AT Traction Power Supply System Based on the Subsection Impedance Method (2012)

A deep research on the contact line (T)-negative feeder(F) short-circuit impedance is made in this paper on the basis of analyzing the advantages and disadvantages of all existing parallel AT power supply system fault location methods . Then, the simulation model of the all parallel AT traction power supply system is established and the characteristic of system impedance under T-F short-circuit condition is simulated and analyzed. The results show that the subsection impedance method basically corresponds to the requirement of engineering application. It also provides some theoretical reference for the T-F short-circuit fault analysis of all parallel AT power supply system.
Role of hypoxia and autophagy in MDA‐MB‐231 invasiveness (2010)

Survival strategies adopted by tumor cells in response to a hypoxic stress include activation of hypoxia-inducible factor 1 (HIF-1) and autophagy. However, the importance and the function of each molecular response is not well defined. In the present study, we investigated invasiveness, migration, matrix metalloproteinases (MMPs) activity, and cell survival of MDA-MB-231 cells under normoxia, hypoxia, and hypoxia/reoxygenation (H/R). Moreover, to assess the importance of hypoxia and autophagy on the parameters studied, cells were either left untreated or treated with Chetomin (a selective inhibitor of HIF-1alpha) or trifluoperazine (TFP, an activator of autophagy). We found that hypoxia and H/R stimulated invasiveness and migration of MDA-MB-231 cells with an increased MMP-2 activity. Chetomin and TFP differently regulated the cellular behavior under the oxygenation conditions studied. In fact, Chetomin was most effective in inhibiting cell invasion, MMPs activity, and cell survival under hypoxia but not normoxia or H/R. By contrast, TFP inhibition of cell invasion, migration, and cell survival was independent from oxygenation conditions. TFP-induced autophagy was inhibited by light chain protein 3 (LC3) silencing or 3-methyladenine (3MA) treatment. In fact, LC3-silenced cells were able to invade in the presence of TFP without any GATE16 processing and p62 degradation. Immunofluorescence assay showed that LC3 silencing inhibited TFP-induced autophagosome formation. However, we also showed that both TPF treatment and LC3 silencing caused cytoskeleton impairments suggesting a possible interaction between LC3 and cytoskeleton components. In conclusion, our study shows that hypoxia and autophagy by acting on common (HIF-1alpha) or separate (MMPs, cytoskeleton) targets differently regulate cell invasion, MMPs activity, and survival.
Comparison of Droop Control and Virtual Oscillator Control Realized by Andronov-Hopf Dynamics (2020)

Virtual oscillator control (VOC) is a time-domain strategy for regulating the operation of grid-forming (GFM) inverters. The premise of this method is to leverage the dynamics of nonlinear oscillator circuits to realize controllers; the time-domain nature of the resulting implementation is starkly different from classical droop control methods. This paper considers VOC realized with the dynamics of the Andronov-Hopf oscillator, a second-order nonlinear dynamical system that enables GFM inverters to be dispatched and generate low-harmonic outputs while not compromising dynamic performance. Leveraging an equilibrium analysis of the involved dynamics and small-signal models, we put forth a side-by-side comparison of dynamic performance and small-signal stability with classical droop control. The results demonstrate superior dynamic performance of VOC, and broadly, the paper furthers efforts focused on modeling and analysis of this general class of GFM controllers.
Adult exercise effects on oxidative stress and reproductive programming in male offspring of obese rats (2014)

Exercise improves health but few data are available regarding benefits of exercise in offspring exposed to developmental programming. There is currently a worldwide epidemic of obesity. Obesity in pregnant women predisposes offspring to obesity. Maternal obesity has well documented effects on offspring reproduction. Few studies address ability of offspring exercise to reduce adverse outcomes. We observed increased oxidative stress and impaired sperm function in rat offspring of obese mothers. We hypothesized that regular offspring exercise reverses adverse effects of maternal obesity on offspring sperm quality and fertility. Female Wistar rats ate chow (C) or high-energy, obesogenic diet (MO) from weaning through lactation, bred at postnatal day (PND) 120, and ate their pregnancy diet until weaning. All offspring ate C diet from weaning. Five male offspring (different litters) ran on a wheel for 15 min, 5 times/week from PND 330 to 450 and were euthanized at PND 450. Average distance run per session was lower in MO offspring who had higher body weight, adiposity index, and gonadal fat and showed increases in testicular oxidative stress biomarkers. Sperm from MO offspring had reduced antioxidant enzyme activity, lower sperm quality, and fertility. Exercise in MO offspring decreased testicular oxidative stress, increased sperm antioxidant activity and sperm quality, and improved fertility. Exercise intervention has beneficial effects on adiposity index, gonadal fat, oxidative stress markers, sperm quality, and fertility. Thus regular physical exercise in male MO offspring recuperates key male reproductive functions even at advanced age: it's never too late.
Valorization of native sugarcane bagasse lignin to bio-aromatic esters/monomers via a one pot oxidation–hydrogenation process (2019)

An oxidation–hydrogenation process using atmospheric O<sub>2</sub> has been developed to convert native bagasse lignin into bio-aromatic esters in a single step.
Femtosecond pulsed light polarization induced effects in direct laser writing 3D nanolithography (2016)

We demonstrate how the coupling between (i) polarization of the writing laser beam, (ii) tight focusing and (iii) heat conduction affects the size, shape and absorption in the laser-affected area and therefore the polymerization process. It is possible to control the sizes of 3D laser-produced structure at the scale of several nanometers. Specifically we were able to tune the aspect ratio of 3D suspended line up to 20% in hybrid SZ2080 resist. The focal spot of tightly focused linearly polarized beam has an elliptical form with the long axis in the field direction. It is shown here that this effect is enhanced by increase in the electronic heat conduction when polarization coincide with temperature gradient along with the absorption. Overlapping of three effects (i- iii) results in the difference of several tens of nanometers between two axes of the focal ellipse. Narrow line appears when polarization and scan direction coincide, while the wide line is produced when these directions are perpendicular to each other. The effect scales with the laser intensity giving a possibility to control the width of the structure on nanometer scale as demonstrated experimentally in this work. These effects are of general nature and can be observed in any laser-matter interaction experiments where plasma produced by using tight focusing of linear-polarized light.
Recession Behavior and Recession Rate Prediction of Silicon Nitride in Combustion Gas Flow (2005)

The influence of various basic factors of combustion gas flow conditions on the recession rate of silicon nitride has been experimentally clarified, and the recession rate equation is deduced using the dependence of influential factors on the recession rate and the mass transfer theory. The exposure tests are performed under various gas flow conditions (T = 1200∼1500°C, P = 0.2∼0.7 MPa, V = 40∼200 m/s, PH2O = 30∼90 kPa, PO2 = 20∼45 kPa, t = 10 h). Recession rates mainly depend on water vapor partial pressure, pressure, gas temperature, and Reynolds number represented the gas flow conditions inside the specimen holder. The dependent on oxygen partial pressure is extremely low for silicon nitride. The recession rates of silicon nitride in combustion gas flow are expressed in the form exp (-E/RT) · (PH2O)n · Re0.8/P, and the predicted recession rates of silicon nitride shows good agreement with reported exposure test results under a gas turbine condition.
Effect of abdominal aortic endoprostheses on arterial pulse wave velocity in an in vitro abdominal aortic flow model (2018)

Endograft placement resulted in a higher aPWV compared to a non-treated aortic flow model. All models showed increased structural stiffness over the flow trajectory compared to the control model, except for the AFX endoprosthesis. Future studies in patients treated with an endograft are needed to evaluate the current results in vivo.
Resistive Switching in $\hbox{TiO}_{2}$ Thin Films Using the Semiconducting In-Ga-Zn-O Electrode (2012)

Resistance switching behaviors in a Pt/In <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ZnO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sub> (IGZO)/TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Pt sample were examined for their potential use in diode-free memory integration. The In-Ga-Zn-O (IGZO) layer worked as the semiconductor layer, exhibiting accumulation or depletion of carriers depending on the polarity of the bias. Electroforming was possible only under the IGZO depletion condition due to the limited background leakage current flow. The repeated set/reset operation was also observed under the depletion condition. While the reset was possible, set was impeded by the high background current flow of the IGZO layer under the accumulation condition.
Domain wall displacement in Py square ring for single nanometric magnetic bead detection (2008)

An approach based on domain wall displacement in confined ferromagnetic nanostructures for attracting and sensing a single nanometric magnetic particle is presented. We modeled and experimentally demonstrated the viability of the approach using an anisotropic magnetoresistance device made by a micron-sized square ring of Permalloy. This detection concept can be suitable to biomolecular recognition and, in particular, to single molecule detection.
Coherent beam superposition of ten diode lasers with a Dammann grating (2010)

International audience
Transient kinetic and isotopic tracer studies of the myosin adenosine triphosphatase reaction (1975)

From transient kinetic studies of the Mg2+-dependent adenosine triphosphatase of myosin subfragment 1, prepared from rabbit skeletal muscle, a seven-step mechanism has been proposed. Features of this mechanism include two-step processes for ATP and ADP binding in which the binary complex isomerizes in addition to a rapid nucleotide association step. In the case of ATP a large negative standard free energy change is associated with the isomerization. An overall rate-limiting isomerization of the myosin-product complex prior to product release has been identified. Studies on the mechanism of cleavage of ATP bound to the active site indicate the process is readily reversible and can account for the observation that more than one oxygen of the product phosphate arises from water. This proposal has been substantiated by the finding that the oxygen atoms of the gamma-phosphoryl group of bound ATP also undergo extensive exchange with water.
mTOR activity is essential for retinal pigment epithelium regeneration in zebrafish (2022)

The retinal pigment epithelium (RPE) plays numerous critical roles in maintaining vision and this is underscored by the prevalence of degenerative blinding diseases like age-related macular degeneration (AMD), in which visual impairment is caused by progressive loss of RPE cells. In contrast to mammals, zebrafish possess the ability to intrinsically regenerate a functional RPE layer after severe injury. The molecular underpinnings of this regenerative process remain largely unknown yet hold tremendous potential for developing treatment strategies to stimulate endogenous regeneration in the human eye. In this study, we demonstrate that the mTOR pathway is activated in RPE cells post-genetic ablation. Pharmacological and genetic inhibition of mTOR activity impaired RPE regeneration, while mTOR activation enhanced RPE recovery post-injury, demonstrating that mTOR activity is essential for RPE regeneration in zebrafish. RNA-seq of RPE isolated from mTOR-inhibited larvae identified a number of genes and pathways dependent on mTOR activity at early and late stages of regeneration; amongst these were components of the immune system, which is emerging as a key regulator of regenerative responses across various tissue and model systems. Our results identify crosstalk between macrophages/microglia and the RPE, wherein mTOR activity is required for recruitment of macrophages/microglia to the RPE injury site. Macrophages/microglia then reinforce mTOR activity in regenerating RPE cells. Interestingly, the function of macrophages/microglia in maintaining mTOR activity in the RPE appeared to be inflammation-independent. Taken together, these data identify mTOR activity as a key regulator of RPE regeneration and link the mTOR pathway to immune responses in facilitating RPE regeneration.
Interpretation of damage caused by a vapor cloud explosion (2019)

Abstract The understanding of vapor cloud explosions (VCEs) has changed significantly over recent years. Whereas it had been previously considered that VCE incidents had involved only deflagrations restricted to well‐defined congested process regions, it is now widely accepted that deflagration to detonation transition (DDT) has been involved in major VCE incidents. Once DDT occurs, high pressures will be generated throughout any remaining unburned cloud, not just the congested process region. The stimulus for this change in understanding was the research conducted following the Buncefield incident in the UK in 2005; however, the conclusions have been found relevant to other VCE incidents. In the process of both conducting the research and reviewing VCE incidents, a significant amount of data have been obtained on the effects of VCEs on items within and around the flammable cloud. These data will be of significant value in the interpretation of the forensic evidence produced in any future VCE. This article reviews the data available from the research and shows how it can be used in the investigation of any future VCE incidents.
The Effect of Clozapine on Cognition and Psychiatric Symptoms in Patients with Schizophrenia (1993)

Psychiatric symptoms and cognition were assessed in 13 patients with schizophrenia, one patient with schizoaffective disorder, and one patient with psychosis not otherwise specified while they received a conventional neuroleptic and again after an average of 15 months on clozapine. Despite improvements in psychiatric symptoms, attention, memory, and higher-level problem-solving were essentially unchanged. This suggests that certain cognitive deficits are relatively independent of psychotic symptoms in schizophrenia, and are probably central and enduring features of the disorder. Cognitive disability appeared to have been rate-limiting in the sample's rehabilitation, as patients' social and vocational adjustment remained marginal during the study. We also observed that treatment with clozapine was associated with a decline in some memory functions; the potent anticholinergic properties of the drug may have been responsible for this.
Dual Targeting of Hypoxia and Homologous Recombination Repair Dysfunction in Triple-Negative Breast Cancer (2014)

Triple-negative breast cancer (TNBC) is an aggressive malignancy with poor clinical outcome and few validated drug targets. Two prevalent features of TNBC, tumor hypoxia and derangement of homologous recombination (HR) repair, are potentially exploitable for therapy. This study investigated whether hypoxia-activated prodrugs (HAP) of DNA-damaging cytotoxins may inhibit growth of TNBC by simultaneously addressing these two targets. We measured in vitro activity of HAP of DNA breakers (tirapazamine, SN30000) and alkylators (TH-302, PR-104, SN30548) in TNBC cell lines and isogenic models, and related this to measures of HR repair and expression of prodrug-activating enzymes. Antitumor activity of HAP was examined in isogenic BRCA2-knockout xenograft models and compared with platinum chemotherapy. All five HAP selectively inhibited growth of TNBC cell lines under hypoxia. Sensitivity to HAP was not strongly associated with BRCA1 genotype. However, HAP sensitivity was enhanced by suppression of HR (assessed by radiation-induced RAD51 focus formation) when BRCA1 and PALB2 were knocked down in a common (MDA-MB-231) background. Furthermore, knockout of BRCA2 markedly sensitized DLD-1 cells to the clinical nitrogen mustard prodrugs TH-302 and PR-104 and significantly augmented sterilization of clonogens by these agents in xenografts, both as monotherapy and in combination with radiotherapy, but had less effect on activity of the benzotriazine di-N-oxide SN30000. PR-104 monotherapy was more effective than cisplatin at inhibiting growth of BRCA2-knockout tumors at equitoxic doses. This study demonstrates the potential for HAP of nitrogen mustards to simultaneously exploit hypoxia and HR defects in tumors, with translational implications for TNBC and other HR-deficient malignancies.
SHARC-II 350 μm OBSERVATIONS OF THERMAL EMISSION FROM WARM DUST INz⩾ 5 QUASARS (2008)

International audience
Hydroxylapatite/poly(L‐lactide) composites: An animal study on push‐out strengths and interface histology (1993)

In the development of new materials for resorbable systems for bone fixation and replacement, composites of hydroxylapatite and poly (L-lactide) (HA/PLLA) were tested. In a transcortical implantation model in goats the interactions at the bone-implant interface were studied with post-operative intervals up to 1 year. Push-out testing of the implants indicated that PLLA reinforced with 50 wt% hydroxylapatite or PLLA plasma-sprayed with a hydroxylapatite coating of 50 microns thickness increases interfacial shear strength at 3 months of implantation when compared to unfilled poly(L-lactide) (P < .01). Scanning electron microscopy showed that the failure mode was predominantly at the coating-implant interface. Implantation periods longer than 3 months did not result in a significant increase in push-out strength because of the resorbing PLLA matrix. In support of the above findings there was histological evidence, on a light microscopical level, of increased bone contact at the interface for the composites, HA incorporated in or coated on PLLA, compared to unfilled poly(L-lactide).