gebhart/patrepeval huggingface dataset:
0609 Samelisant, Histamine 3 Receptor Agonist for the Potential Treatment of Excessive Daytime Sleepiness in Patients with Narcolepsy (2023)

Abstract Introduction Samelisant (SUVN-G3031) is a potent and selective histamine 3 receptor inverse agonist. In orexin knockout mice, samelisant produced wake-promoting and anticataplectic effects suggesting its potential therapeutic utility in the treatment of narcolepsy. Safety and tolerability studies in animals and healthy human volunteers suggested a favorable risk/benefit profile for samelisant. Methods Samelisant is currently being evaluated in a double blind, Phase-2 proof of concept study in USA and Canada for narcolepsy with or without cataplexy (ClinicalTrials.gov Identifier: NCT04072380). The study is recruiting subjects diagnosed with narcolepsy as per ICSD-3 criteria, aged between 18 to 65 years with an Epworth Sleepiness Scale (ESS) score of ≥12 and mean Maintenance of Wakefulness Test (MWT) time of &amp;lt; 12 min. A total of 171 subjects are expected to be randomized into 3 treatment arms (placebo, samelisant 2 mg and samelisant 4 mg) in 1:1:1 ratio. Each subject will receive either placebo or study drug once daily for 2 weeks. The primary efficacy endpoint is change in MWT score from baseline to week 2. Key secondary endpoint is change in ESS from baseline to week 2. Safety will be monitored throughout the study by medical monitor and by data safety monitoring committee. As the study is still recruiting, demographics and baseline characteristic data for the currently enrolled subjects is summarized descriptively. Since the study is blinded, a breakdown of baseline characteristics by treatment group will not be available until after completion. Results At the data cutoff date of Nov 30, 2022, a total of 155 subjects were randomized in the study. The median age of subjects was 30 years (range: 18-57 years) with mean BMI of 28.5 kg/m2 (range: 18.3- 43.9 kg/m2). Overall, 57% subjects were of narcolepsy type-1, 71% were female and 71% were Caucasian. Mean (SD) baseline values of MWT and ESS scores were 6.1 (4.4) and 17.2 (2.8), respectively. Conclusion Baseline characteristics are consistent with the general narcolepsy population. The study is currently enrolling subjects with narcolepsy and the data readout is expected in Q2 2023. Support (if any)
In vivo Imaging Technologies to Monitor the Immune System (2020)

The past two decades have brought impressive advancements in immune modulation, particularly with the advent of both cancer immunotherapy and biologic therapeutics for inflammatory conditions. However, the dynamic nature of the immune response often complicates the assessment of therapeutic outcomes. Innovative imaging technologies are designed to bridge this gap and allow non-invasive visualization of immune cell presence and/or function in real time. A variety of anatomical and molecular imaging modalities have been applied for this purpose, with each option providing specific advantages and drawbacks. Anatomical methods including magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound provide sharp tissue resolution, which can be further enhanced with contrast agents, including super paramagnetic ions (for MRI) or nanobubbles (for ultrasound). Conjugation of the contrast material to an antibody allows for specific targeting of a cell population or protein of interest. Protein platforms including antibodies, cytokines, and receptor ligands are also popular choices as molecular imaging agents for positron emission tomography (PET), single-photon emission computerized tomography (SPECT), scintigraphy, and optical imaging. These tracers are tagged with either a radioisotope or fluorescent molecule for detection of the target. During the design process for immune-monitoring imaging tracers, it is important to consider any potential downstream physiologic impact. Antibodies may deplete the target cell population, trigger or inhibit receptor signaling, or neutralize the normal function(s) of soluble proteins. Alternatively, the use of cytokines or other ligands as tracers may stimulate their respective signaling pathways, even in low concentrations. As <i>in vivo</i> immune imaging is still in its infancy, this review aims to describe the modalities and immunologic targets that have thus far been explored, with the goal of promoting and guiding the future development and application of novel imaging technologies.
Towards automating an interventional radiology procedure (2004)

A system supporting an interventional radiology (IR) procedure is presented in this paper. A 3D geometric modeling method has been developed to construct a 3D vascular model containing complete connection information of cerebral vasculature for IR planning and intra-operative guidance. The validation result proved the fidelity of the reconstructed model. A magnetic tracking system is employed in this project to trace the tip of the IR device, whose model can be displayed onto a 3D digital model in real time. Magnetic tracking of IR device plus the 3D model can potentially help the radiologist more easily manipulate IR device through vasculature. A method following automatic guidance of IR device (such as catheter and guidewire) from the entry to target is proposed, which can reduce the radiation dose and thus benefit both patients and staff.
Handheld Nerve Electrode Insertion Tool (2018)

This paper introduces a new type of miniature device to insert an intrafascicular electrode into a peripheral nervous system that is covered with tough tissue membranes. The developed device is called nerve electrode insertion tool (NEIT) and consists of a nerve holder unit and an electrode insertion unit. Users can easily adjust the insertion position and direction of nerve electrodes while freely manipulating this compact handheld device. This paper introduces the form, configuration, and underlying mechanisms of the device and related surgical procedure. Utility tests using elastomer-made nerve models show that the electrode insertion time and position accuracy, respectively, improve from 72.1 to 4.17 s and 0.37 to 0.11 mm when employing the NEIT. Animal experiment results show that multishank planar electrodes (2 × 2 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) are successfully implanted into sciatic nerves of six rats. Treadmill tests and histological analysis present the neural functions of all the treated nerves are successfully recovered after three weeks. We expect the NEIT to be employed for other kinds of nerve electrodes and simplify the surgical process in neural engineering research.
A novel broadband all-wireless access network using stratospheric platforms (2002)

This paper proposes a novel broadband access network using a number of stratospheric platforms. This is a new wireless infrastructure, and consists of wireless access links between the platform and terminals in the Ka-band and a mesh-like network using optical inter-platform links. One platform covers a 40 km/spl times/40 km area with 64 beams of an onboard multi-beam antenna. Thus, the cell size is almost as same as that of current cellular systems. This network can provide 25 Mbps to more than 156 Mbps access links and a flexible wireless ATM network to subscribers.
Strongly disordered chain of impedances: theoretical analysis and numerical results (1990)

The authors study the input impedance of a chain of random resistors chosen according to a 'broad' distribution (i.e. decaying as a power law for large arguments). As a function of frequency, the modulus of the input impedance varies as a power law, while its phase has a well defined value. A simple theoretical analysis, based on estimations of sums of random variables, yields the value of the exponents which are in perfect agreement with numerical simulations, even when logarithmic corrections come into play. The analysis can be extended further to investigate the sample to sample fluctuations of the impedance. Again, agreement with simulations is very good.
Studies on Vitamin B<sub>1</sub> and Related Compounds. XXXVII (1952)

The change of vitamin B1 when it was heated in an aqueous solution of pH 8 at 60° for 2.5 hours was examined by paper partition chromatography, and it was found that thiochrome (IV), SB1 (VII), B1 disulfide (V), and B1 thiazolone (VI) had been formed. However, a large amount of vitamin B1 was found to be still intact. The same procedure carried out in alcohol, instead of water, showed that almost none of vitamin B1 remained, and that the formation of SB1 (VII) was larger than in the case of aqueous solutions, SB1 being obtained as crystals. Other compounds formed were (IV), (V), and (VI), as in the case of aqueous solutions
Self-assembled organic semiconductors for monolayer field-effect transistors (2014)

Recent data on the structures and properties of self-organized molecules used for the production of the semiconducting layer in self-assembled organic monolayer field-effect transistors are reviewed. Methods for fabrication of these transistors are presented together with their advantages and shortcomings. Electric characteristics of the produced devices are compared. Major structural regularities for selection of the reactive group in self-organized semiconductor oligomer molecules are elucidated with respect to the type of substrate.
Major hepatic resection and portal pressure. (1977)

Although other reports have stressed the inevitability of portal hypertension and splanchnic pooling following major liver resections, clinical observations during 30 major hepatic resections and measurements of portal pressure in three consecutive trisegmentectomies fail to support this contention. If the remaining liver is normal and careful anatomic dissection is used, major resections can be performed without inducing portal hypertension.
[Role of folates in the nutrition of the elderly]. (2004)

Inadequate folate intake and in consequence deficient of plasma folate status may have a negative impact on human health. Among elderly the most important effects are related to hyperhomocysteinemia, a significant risk factor for cardiovascular diseases, procarcinogenic effects and cognitive dysfunctions. To prevent such situation and improve the quality of life of elderly people, in Poland as in many other countries, different strategies for increasing folate intake were applied, among them food fortification. At the same time it is important to educate people because food fortification and individual diet supplementation applied together could be a risk of exceeding upper level of folate intake.
Concentrations of conjugated linoleic acid (cis-9, trans-11-octadecadienoic acid) are not increased in tissue lipids of cattle fed a high-concentrate diet supplemented with soybean oil1 (2002)

Conjugated linoleic acid (CLA), a mixture of isomers of linoleic acid, has many beneficial effects, including decreased tumor growth in animal cancer models. The cis-9, trans-11 isomer of CLA (CLA9,11) can be formed in the rumen as an intermediate in biohydrogenation of linoleic acid. Recent data, however, indicate that tissue desaturation of trans-fatty acids is an important source of CLA9,11 in milk. Our objective was to determine whether supplementing a high-corn diet with soybean oil (SBO; a source of linoleic acid) would increase concentrations of CLA in ruminal contents and tissue lipids. Four ruminally cannulated steers were utilized in a Latin square design with 28-d periods. A control diet (80% cracked corn, 2.0% corn steep liquor, 8.0% ground corn cobs, and 10% supplement [soybean meal, ground shelled corn, minerals, and vitamins]) was supplemented with 2.5, 5.0, or 7.5% (DM basis) SBO. Supplemental SBO did not affect ruminal pH or concentrations of the major VFA. The proportion and amount (mg FA/g DM ruminal contents) of CLA9,11 were not increased by increasing dietary SBO. However, the proportion and amount of the trans-10, cis-12 CLA isomer (CLA10,12) in ruminal contents increased linearly (P < 0.006) as dietary SBO increased. Trans-18:1 isomers in ruminal contents increased linearly (P < 0.02) as dietary SBO increased. The proportion of CLA10,12 was correlated positively (P < 0.001) with proportions of trans-C 18:1 isomers in ruminal contents. Conversely, CLA9,11 was correlated negatively (P < 0.05) with the proportions of trans-18:1 in ruminal contents. The same high-corn diet, supplemented with 0 or 5% SBO, was fed to 20 Angus-Wagyu heifers for 102 d in a randomized complete block design to determine the effect of added SBO on tissue deposition of CLA. Supplemental SBO did not affect feed intake, gain:feed, or carcass quality. Tissue samples were obtained from the hindquarter, loin, forequarter, liver, large and small intestine, and subcutaneous, mesenteric, and perirenal adipose depots. The concentration of CLA9,11 was greatest in subcutaneous adipose tissue but was not affected in any tissue by SBO. Supplementing high-corn diets with SBO does not increase CLA9,11 concentrations in tissues of fattening heifers. Research is needed to identify regulatory factors for pathways of biohydrogenation that lead to increased concentrations of CLA10,12 in ruminal contents when high-oil, high-concentrate diets are fed.
The future role of image sequence analysis in oceanography (2002)

The sea surface is a spatio-temporal phenomenon. The acquisition and analysis of image sequences of the sea surface therefore allows a complete representation of the sea state. In nature ship- or land-based nautical radar is used to acquire image sequences. In simulations, i.e., hydraulic wave tanks, optical sensors are used for this purpose. From the image sequences it is possible to determine a set of hydrographic parameters such as wave spectra, current-vector fields, and bathymetry. Examples of applications are presented to show the potential of the methods to monitor coastal or offshore wave fields in the context of an integrated approach.
Porous graphene oxide frameworks: Synthesis and gas sorption properties (2011)

We report detailed synthesis of a range of porous graphene oxide frameworks (GOFs) by expansion of graphene oxide (GO) sheets with various linear boronic acid pillaring units in a solvothermal reaction. The GOF structures develop through boronate-ester formation as a result of B–O bonding between boronic acids and oxygen functional groups on the GO layers. Synthesized GOFs exhibit periodic layered structures with largely expanded interlayer spacing as characterized by X-ray powder diffraction (XRD). The boronate-ester link formation is further evidenced by Fourier transform infrared (FTIR) and Raman spectroscopy. Furthermore, the strong boronate-ester bonds between GO layers results in improved thermal stability over the precursor GO. The solvent-free, evacuated frameworks provide highly increased accessible surface area for nitrogen adsorption compared to GO alone, which depends on the type and length of the boronic acid, indicating the importance of pillaring unit. Both isosteric heat of adsorption (Qst) and the adsorbed hydrogen capacity per surface area are twice as large as typical porous carbon materials and comparable to metal–organic frameworks (MOFs) with open metal centers. This enhanced Qst and adsorption capacity is attributed to optimum interlayer spacing between graphene planes such that hydrogen molecules interact with both surfaces. Finally, our systematic study reveals the profound effect of both synthesis and activation temperatures to obtain porous framework structures.
PlantGenIE-PLAZA : integrating orthology into the PlantGenIE.org resource using the PLAZA pipeline (2020)

PlantGenIE-PLAZA : integrating orthology into the PlantGenIE.org resource using the PLAZA pipeline
Synthesis Of Graphene/Chitosan Nanocomposite Thin Films (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation S. Ganesh, Arockiadoss, S. Ramaprabhu; Synthesis Of Graphene/Chitosan Nanocomposite Thin Films. AIP Conf. Proc. 4 October 2010; 1276 (1): 158–162. https://doi.org/10.1063/1.3504291 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Improving Efficiency in Clinical Trials Using Auxiliary Information: Application of a Multi-State Cure Model (2015)

In clinical trials, an intermediate marker measured after randomization can often provide early information about the treatment effect on the final outcome of interest. We explore the use of recurrence time as an auxiliary variable for estimating the treatment effect on overall survival in phase three randomized trials of colon cancer. A multi-state model with an incorporated cured fraction for recurrence is used to jointly model time to recurrence and time to death. We explore different ways in which the information about recurrence time and the assumptions in the model can lead to improved efficiency. Estimates of overall survival and disease-free survival can be derived directly from the model with efficiency gains obtained as compared to Kaplan-Meier estimates. Alternatively, efficiency gains can be achieved by using the model in a weaker way in a multiple imputation procedure, which imputes death times for censored subjects. By using the joint model, recurrence is used as an auxiliary variable in predicting survival times. We demonstrate the potential use of the proposed methods in shortening the length of a trial and reducing sample sizes.
Preparation of 1,5‐Disubstituted 1,2,3‐Triazoles via Ruthenium‐catalyzed Azide Alkyne Cycloaddition (2014)

Abstract Phenylacetylene Benzyl azide Chloro(1,5‐cyclooctadiene)(pentamethylcyclopentadiene)‐ruthenium 1‐Benzyl‐5‐phenyl‐1H‐1,2,3‐triazole
Ladder-Type Polyenazine Based on Intramolecular S···N Interactions: A Theoretical Study of a Small-Bandgap Polymer (2009)

Ladder-type polyenazine (LPEA, 2), a nitrogen-containing polymer analogous to polyacetylene (PA), is proposed, based on molecule 1 synthesized and characterized earlier.8 By using density functional theory calculations, we show that the ladder-type structure of the proposed polymer arises from the intramolecular S···N interactions, which reduce the bond length alternation of the polymer and hence lead to a significantly narrower bandgap compared to the parent PA. A σ-conjugated pathway is found along the ···S−S···N−N···S--S··· linkage due to the noncovalent S···N interactions and NN through-space interactions. The theoretically predicted electron affinity of the proposed LPEA lies in the range for n-type semiconductors. We examine the energy barrier from the equilibrium geometry to the geometry of uniform bond length pattern and find that the estimated energy barrier is very similar to that of the parent PA.
On the Impact of Shear Flow Instabilities on Global Heat Release Rate Fluctuations: Linear Stability Analysis of an Isothermal and a Reacting Swirling Jet (2012)

The prediction of large-scale flow structures in combustor flows and their impact on the flame dynamics is of great importance to avoid thermoacoustic instabilities in modern gas turbine design. The streamwise growth of these so-called coherent structures depends on the receptivity of the shear layers, which can be predicted numerically by means of linear stability analysis. We demonstrate this approach on an isothermal swirling jet that is dominated by a self-excited helical mode that features a precessing vortex core, showing that this theoretical concept successfully predicts the frequency, the source, and the shape of this mode. The analysis is further applied to a reacting flow with a swirl-stabilized flame, pointing out important connections between the shear layer receptivity and the measured amplitude dependence of the flame transfer function. The theoretical findings suggest that the saturation of the global heat release rate fluctuations observed at moderate forcing amplitudes is caused by vanishing shear layer receptivity.
Si-based RF MEMS components. (2005)

Radio frequency microelectromechanical systems (RF MEMS) are an enabling technology for next-generation communications and radar systems in both military and commercial sectors. RF MEMS-based reconfigurable circuits outperform solid-state circuits in terms of insertion loss, linearity, and static power consumption and are advantageous in applications where high signal power and nanosecond switching speeds are not required. We have demonstrated a number of RF MEMS switches on high-resistivity silicon (high-R Si) that were fabricated by leveraging the volume manufacturing processes available in the Microelectronics Development Laboratory (MDL), a Class-1, radiation-hardened CMOS manufacturing facility. We describe novel tungsten and aluminum-based processes, and present results of switches developed in each of these processes. Series and shunt ohmic switches and shunt capacitive switches were successfully demonstrated. The implications of fabricating on high-R Si and suggested future directions for developing low-loss RF MEMS-based circuits are also discussed.
Latest Developments in the Xyce Large-Scale Analog Circuit Simulator. (2020)

Abstract not provided.
Preparation of Nucleic Acid Vaccine and Immune Tests of Canine parvovirus (2006)

The VP1 gene of Canine parvovirus was amplified by PCR and digested by BamHⅠ and NotⅠ,and was cloned into pIRESneo expressing vector.Recombinant plasmid pIRESVP1 was extracted and digested with enzymes and sequenced to confirm its rightness.Six dogs were injected at 9 months old with increasing doses of pIRESVP1 or pIRESneo and saline.All dogs were challenged with virulent CPV after the third injection.NAV vaccinated dogs serum showed a high IgG titer after the second injection and six dogs were protected against infection,while the control dogs were fully susceptible.This study demonstrated that NAV of CPV can protect dogs against virulent CPV.