gebhart/patrepeval huggingface dataset:
Twelve Years' Experience with National Sharing of HLA-Matched Cadaveric Kidneys for Transplantation (2000)

A superior graft outcome with little increase in the duration of cold ischemia justifies national sharing of HLA-matched kidney transplants.
A New Evaluation Method of Hydrogen Embrittlement Fracture for High Strength Steel by Local Approach (2005)

An evaluation method for hydrogen embrittlement (HE) susceptibility for ultra high strength steel was studied. The study showed that the evaluation results obtained by the method were independent of the stress concentration factor and the dimension of the specimen. A commercial 0.40C-0.24Si-0.81Mn-1.03Cr-0.16Mo (mass%) steel with a tensile strength of 1400 MPa was used. The Local Approach, which was originally used for the evaluation of brittle fracture property, was applied to evaluate the HE susceptibility. The method was modified to consider the effect of hydrogen content to evaluate the HE susceptibility. The critical HE data, which were required in the modified Local Approach, were obtained by the stepwise test in which the stress increasing process and the stress holding process were alternatively repeated until the specimen fractured. The dimensions of the specimen used in the stepwise test consisted of a diameter of 10 mm and a stress concentration factor of 4.9. To evaluate the HE susceptibility for specimens with other dimensions, a critical hydrogen content for failure called Hc, which represents the maximum hydrogen content among the unfracture specimens on the HE test with constant loading, was used. It was found that the HE susceptibility could be evaluated by the modified Local Approach considering hydrogen content distribution in the specimens and that the probability of the HE fracture on the components could be designed by using the evaluation results.
Synthesis, Self‐Assembly, and Multi‐Stimuli Responses of a Supramolecular Block Copolymer (2014)

A supramolecular block copolymer is prepared by the molecular recognition of nucleobases between poly(2-(2-methoxyethoxy)ethyl methacrylate-co-oligo(ethylene glycol) methacrylate)-SS-poly(ε-caprolactone)-adenine (P(MEO<sub>2</sub> MA-co-OEGMA)-SS-PCL-A) and uracil-terminated poly(ethylene glycol) (PEG-U). Because the block copolymer is linked by the combination of covalent (disulfide bond) and noncovalent (AU) bonds, it not only has similar properties to conventional covalently linked block copolymers but also possesses a dynamic and tunable nature. The copolymer can self-assemble into micelles with a PCL core and P(MEO<sub>2</sub> MA-co-OEGMA)/PEG shell. The size and morphologies of the micelles/aggregates can be adjusted by altering the temperature, pH, salt concentration, or adding dithiothreitol (DTT) to the solution. The controlled release of Nile red is achieved at different environmental conditions.
Role of GRK4 in the Regulation of Arterial AT 1 Receptor in Hypertension (2013)

G-protein-coupled receptor kinase 4 (GRK4) gene variants, via impairment of renal dopamine receptor and enhancement of renin-angiotensin system functions, cause sodium retention and increase blood pressure. Whether GRK4 and the angiotensin type 1 receptor (AT(1)R) interact in the aorta is not known. We report that GRK4 is expressed in vascular smooth muscle cells of the aorta. Heterologous expression of the GRK4γ variant 142V in A10 cells increased AT(1)R protein expression and AT(1)R-mediated increase in intracellular calcium concentration. The increase in AT(1)R expression was related to an increase in AT(1)R mRNA expression via the NF-κB pathway. As compared with control, cells expressing GRK4γ 142V had greater NF-κB activity with more NF-κB bound to the AT(1)R promoter. The increased AT(1)R expression in cells expressing GRK4γ 142V was also associated with decreased AT(1)R degradation, which may be ascribed to lower AT(1)R phosphorylation. There was a direct interaction between GRK4γ and AT(1)R that was decreased by GRK4γ 142V. The regulation of AT(1)R expression by GRK4γ 142V in A10 cells was confirmed in GRK4γ 142V transgenic mice; AT(1)R expression was higher in the aorta of GRK4γ 142V transgenic mice than control GRK4γ wild-type mice. Angiotensin II-mediated vasoconstriction of the aorta was also higher in GRK4γ 142V than in wild-type transgenic mice. This study provides a mechanism by which GRK4, via regulation of arterial AT(1)R expression and function, participates in the pathogenesis of conduit vessel abnormalities in hypertension.
Automation of the APS 11-BM high-resolution and high-throughput powder diffractometer (2008)

crystallography. Recently, an interest has grown for protein powder diffraction which is becoming a well-established method in the field of structure refinement and molecular replacement. With the use of two examples it is shown that de novo solutions to the phase problem can be obtained at low resolution via phasing methods such as the isomorphous replacement method. Using synchrotron radiation, high quality protein powder patterns have been collected in which pHand radiation-induced anisotropic lattice changes were exploited in order to reduce the challenging and powder specific problem of overlapping reflections. The Single Isomorphous Replacement method enabled the computation of molecular envelopes and the mapping out of the solvent channels in the crystal. Electron density maps in which features of the secondary structure of the lysozyme protein molecule can be discerned, were then obtained using the Multiple Isomorphous Replacement method (as illustrated in the image).
Tridecavanadate, [V13O34]3-, a new high-potential isopolyvanadate (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTridecavanadate, [V13O34]3-, a new high-potential isopolyvanadateDong Hou, Karl S. Hagen, and Craig L. HillCite this: J. Am. Chem. Soc. 1992, 114, 14, 5864–5866Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/ja00040a061https://doi.org/10.1021/ja00040a061research-articleACS PublicationsRequest reuse permissionsArticle Views649Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Bayesian Classifiers Programmed in SQL (2009)

The Bayesian classifier is a fundamental classification technique. In this work, we focus on programming Bayesian classifiers in SQL. We introduce two classifiers: naive Bayes and a classifier based on class decomposition using K-means clustering. We consider two complementary tasks: model computation and scoring a data set. We study several layouts for tables and several indexing alternatives. We analyze how to transform equations into efficient SQL queries and introduce several query optimizations. We conduct experiments with real and synthetic data sets to evaluate classification accuracy, query optimizations, and scalability. Our Bayesian classifier is more accurate than naive Bayes and decision trees. Distance computation is significantly accelerated with horizontal layout for tables, denormalization, and pivoting. We also compare naive Bayes implementations in SQL and C++: SQL is about four times slower. Our Bayesian classifier in SQL achieves high classification accuracy, can efficiently analyze large data sets, and has linear scalability.
Prologue (2011)

There is nothing like returning to a place that remains unchanged to find the ways in which you yourself have altered.Nelson Mandela
Activity of penicillin, erythromycin, and cephalosporins against isolates of Coryntbaeterimm diphtheriae from cutaneous lesions (1979)

Journal Article Activity of penicillin, erythromycin, and cephalosporins against isolates of Coryntbaeterimm diphtheriae from cutaneous lesions Get access DAVID GREGORY, DAVID GREGORY Department of Medicine, Harborview Medical Center, University of WashingtonSeattle, Washington 98104, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar DOLORES ZELEZNIK, DOLORES ZELEZNIK Department of Medicine, Harborview Medical Center, University of WashingtonSeattle, Washington 98104, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. P. HARNISCH, J. P. HARNISCH Department of Medicine, Harborview Medical Center, University of WashingtonSeattle, Washington 98104, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar G. W. COUNTS G. W. COUNTS Department of Medicine, Harborview Medical Center, University of WashingtonSeattle, Washington 98104, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Antimicrobial Chemotherapy, Volume 5, Issue 4, July 1979, Pages 479–481, https://doi.org/10.1093/jac/5.4.479 Published: 01 July 1979
Data Center Mobility based on E-VPN, BGP/MPLS IP VPN, IP Routing and NHRP (2014)

This document describes a set of network-based solutions for seamless
Virtual Machine mobility in the data center. These solutions provide a
toolkit which is based on IP routing, E-VPNs, BGP/MPLS IP VPNs, and
NHRP.
Pesticides and mortality from hormone-dependent cancers (2001)

Endocrine-disrupting chemicals are considered to be a possible cause of hormone-dependent cancers. In areas of high exposure to pesticides, people are concerned about the long lasting toxicity of pesticides, some of which are possibly hormonally active. We collected for each Belgian municipality (n = 589) the latest mortality statistics from breast and prostate cancer (period 1985-1994) and the latest data on crops and pesticides (1998). In addition, data on possible confounders such as population density, degree of urbanization, industrial activity and the presence of an incinerator were collected as well. The data were analysed with spatial statistics that takes into account the spatial nature of the data. There is a large variation in crops and pesticide exposure among the municipalities, the highest exposure being seen in the fruit production area. Apart from use of defoliants and potato cultivation, no consistent correlation was detected between crops, pesticides and mortality from breast and prostate cancer. Our data cannot support the hypothesis of a relationship between total and class-related pesticide use and breast and prostate cancer mortality. However, the increased mortality due to breast cancer and to a lesser extent due to prostate cancer in traditional potato-growing areas needs attention and more research.
Rate-intensity functions and their modification by broadband noise for neurons in the guinea pig inferior colliculus (1988)

Rate-intensity functions (RIFs) were generated in response to characteristic frequency (CF) tones presented alone and in the presence of broadband noise for neurons in the central nucleus of the inferior colliculus (IC) of the anesthetized guinea pig. Seventy-six percent of the RIFs to CF tones were monotonic (some showing incomplete saturation), and 24% were nonmonotonic. The RIFs to continuous noise were more nonmonotonic than those to CF tones. In continuous or gated noise, the dynamic portion of the RIF to a tone was shifted to a higher tone level, with little change in the dynamic range. Above a threshold noise level, the shift was a linear function of noise level with slope 0.97. Little shift occurred when the noise was inversely gated with respect to the tone burst, suggesting that the underlying mechanism is suppression rather than adaptation. For 63% of units, the maximum discharge rate to a tone in low levels (less than 0-dB spectrum level) of noise (including inversely gated) was greater than to the tone alone. Although many of the effects of noise in the IC reflect peripheral mechanisms, they are supplemented by centrally based processes which enhance the detectability of tone intensity increments in the presence of noise.
The conversion of a scientific model describing dairy cow nutrition and production to an industry tool: the CPM dairy project. (2000)

This chapter describes our efforts to convert a large dairy cow nutrition model suite into a commercial product. The scientific model chosen as the basis for the product was the Cornell Net Carbohydrate and Protein System (CNCPS) and the product deriving from this effort was the Cornell Pennsylvania Miner Dairy (CPM-Dairy) Program.
Comprehensive Analysis and Gain Derivation of Phase-Shifted Dual-Input LLC Converter (2022)

This paper presents a comprehensive time-domain analysis of the dual-input LLC converter. By utilizing PSM and FSM, the converter power stage interfaces two photovoltaic (PV) panels to achieve maximum power point tracking (MPPT). The detailed mode-by-mode operation and steady-state analysis are derived using three parameters: the switching frequency, phase shift, and load weight. Furthermore, the DC gain equations of each PV panel and their characteristic curves are derived. In addition, the waveform boundaries and ZVS analysis are discussed as well. Moreover, an extended perturbation & observation (P&O) algorithm that guarantees achieving MPPT for each panel is proposed. Finally, the theoretical analysis has been tested and verified by a 450-W prototype of dual-input LLC converter.
Interfaces between 4H-SiC and SiO2: Microstructure, nanochemistry, and near-interface traps (2004)

We report on electrical and microscopic investigations aimed to clarify the origin of near-interface traps (NITs) in metal–silicon dioxide–4H-silicon carbide structures. Using capacitance–voltage and thermal dielectric relaxation current (TDRC) analysis we investigated NITs close to the 4H-SiC conduction-band edge in differently prepared thermal and deposited oxides and found that the traps give rise to two characteristic TDRC signatures belonging to two groups of trap levels. The total trapped charge exceeds 1×1013cm−2. The observed density and energy distribution of these traps are nearly identical in all thermal and deposited oxides investigated, suggesting that the NITs belong to intrinsic defects at the SiO2∕SiC interface which are readily formed during oxide deposition or thermal oxidation of 4H-SiC. Using high-resolution electron microscopy combined with nanochemical analysis (electron energy-loss near-edge spectroscopy and energy-filtered transmission electron microscopy) we investigated the SiO2∕SiC interface in samples receiving reoxidation and did not find any indication of graphitic regions at or near the SiO2∕SiC interface or in the bulk silicon dioxide within a detection limit of 0.7nm. In addition, no amorphous carbon accumulation was observed near the SiO2∕SiC interface. The overall results strongly suggest that the NITs near the 4H-SiC conduction band are not related to carbon structures in the SiO2∕SiC interlayer.
ChemInform Abstract: (R)‐(+)‐Noranicanine. A New Type of Trioxygenated Benzylisoquinoline Isolation and Synthesis. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Description of Cardiological Apps From the German App Store: Semiautomated Retrospective App Store Analysis (2018)

SARASA provides an easy to use method for applying filtering processes to identify apps matching predefined, formal criteria from app stores. The criteria can be well adapted to the needs of users. Automatic and manual analyses are easily combined when using SARASA. In the future, additional features, such as algorithmic topic analyses, may supplement the process. Although the area of application is currently limited to Apple's App Store, expansion to other stores is planned. The method stands or falls with the transparency of the app store providers and the manufacturers to make relevant meta-information available. It is up to them to liberalize information and restrict censorship to provide clients, customers, and users truly fair circumstances finding their way around the app market.
Síntomas Músculo Esqueléticos y Percepción de Calidad de Vida en Salud en trabajadores de una Curtiembre (2012)

La percepción individual de calidad de vida en relación a la salud (CVS) puede estar relacionada con alteraciones físicas como desórdenes musculo esqueléticos (DME), lo cual puede convertirse en un factor de riesgo desencadenante de enfermedades profesionales, generando repercusiones económicas relacionadas con el ausentismo laboral. Objetivo: Establecer la relación entre los síntomas músculo esqueléticos (SME) y la percepción de CVS en los trabajadores de una Curtiembre. Metodología: Estudio observacional descriptivo en 56 trabajadores de una Curtiembre del Valle del Cauca. Para la recolección de datos se utilizaron los cuestionarios: Nórdico, que identifica presencia de SME; y el SF-36, que evalúa la CVS. Se exploró la relación de las dimensiones de calidad de vida y los SME. Resultados: El DME de mayor prevalencia fue Dolor a Nivel de Cuello (60,7%), seguido por Dolor Lumbar (58,9%) y Dolor en Muñecas (48,2%). Las dimensiones más afectadas de la CVS fueron: Transición en Salud (53,6%), Salud General (26,8%) y Dolor Corporal (19,6%). En los trabajadores con riesgo Alto en las esferas relacionadas con la Salud Mental, los SME de mayor prevalencia fueron de Dolor Lumbar (32,1%), Dolor en Muñecas (26,8%) y Dolor en Hombros (23,2%). Se presentó mayor prevalencia de Dolor Lumbar (23,2%), seguido de Dolor en Cuello (19,6%) y Dolor en Hombros (14,3%) en Riesgo Medio y Alto en las esferas relacionadas con la Salud Física. Conclusiones: Según estos resultados existe una relación entre los SME y la percepción de CVS.
Epidermis Microstructure Inspired Graphene Pressure Sensor with Random Distributed Spinosum for High Sensitivity and Large Linearity (2018)

Recently, wearable pressure sensors have attracted tremendous attention because of their potential applications in monitoring physiological signals for human healthcare. Sensitivity and linearity are the two most essential parameters for pressure sensors. Although various designed micro/nanostructure morphologies have been introduced, the trade-off between sensitivity and linearity has not been well balanced. Human skin, which contains force receptors in a reticular layer, has a high sensitivity even for large external stimuli. Herein, inspired by the skin epidermis with high-performance force sensing, we have proposed a special surface morphology with spinosum microstructure of random distribution via the combination of an abrasive paper template and reduced graphene oxide. The sensitivity of the graphene pressure sensor with random distribution spinosum (RDS) microstructure is as high as 25.1 kPa<sup>-1</sup> in a wide linearity range of 0-2.6 kPa. Our pressure sensor exhibits superior comprehensive properties compared with previous surface-modified pressure sensors. According to simulation and mechanism analyses, the spinosum microstructure and random distribution contribute to the high sensitivity and large linearity range, respectively. In addition, the pressure sensor shows promising potential in detecting human physiological signals, such as heartbeat, respiration, phonation, and human motions of a pushup, arm bending, and walking. The wearable pressure sensor array was further used to detect gait states of supination, neutral, and pronation. The RDS microstructure provides an alternative strategy to improve the performance of pressure sensors and extend their potential applications in monitoring human activities.
Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial (2021)

Manipulations to slow biological aging and extend healthspan are of interest given the societal and healthcare costs of our aging population. Herein we report on a randomized controlled clinical trial conducted among 43 healthy adult males between the ages of 50-72. The 8-week treatment program included diet, sleep, exercise and relaxation guidance, and supplemental probiotics and phytonutrients. The control group received no intervention. Genome-wide DNA methylation analysis was conducted on saliva samples using the Illumina Methylation Epic Array and DNAmAge was calculated using the online Horvath DNAmAge clock (2013). The diet and lifestyle treatment was associated with a 3.23 years decrease in DNAmAge compared with controls (p=0.018). DNAmAge of those in the treatment group decreased by an average 1.96 years by the end of the program compared to the same individuals at the beginning with a strong trend towards significance (p=0.066). Changes in blood biomarkers were significant for mean serum 5-methyltetrahydrofolate (+15%, p=0.004) and mean triglycerides (-25%, p=0.009). To our knowledge, this is the first randomized controlled study to suggest that specific diet and lifestyle interventions may reverse Horvath DNAmAge (2013) epigenetic aging in healthy adult males. Larger-scale and longer duration clinical trials are needed to confirm these findings, as well as investigation in other human populations.
Contributions académiques à l'ANR ICARE (2016)

Présentation au nom des partenaires universitaires du projet ANR ICARE (U. Toulouse, GeM Nantes, LMT-Cachan)
Mechanism of Membrane Anchoring Affects Polarized Expression of Two Proteins in MDCK Cells (1989)

The signals that direct membrane proteins to the apical or basolateral plasma membrane domains of polarized epithelial cells are not known. Several of the class of proteins anchored in the membrane by glycosyl-phosphatidylinositol (GPI) are expressed on the apical surface of such cells. However, it is not known whether the mechanism of membrane anchorage or the polypeptide sequence provides the sorting information. The conversion of the normally basolateral vesicular stomatitis virus glycoprotein (VSV G) to a GPI-anchored protein led to its apical expression. Conversely, replacement of the GPI anchor of placental alkaline phosphatase with the transmembrane and cytoplasmic domains of VSV G shifted its expression from the apical to the basolateral surface. Thus, the mechanism of membrane anchorage can determine the sorting of proteins to the apical or basolateral surface, and the GPI anchor itself may provide an apical transport signal.
Immobilized Zn(OAc)2 on bipyridine-based periodic mesoporous organosilica for N-formylation of amines with CO2 and hydrosilanes (2021)

Zn(OAc)<sub>2</sub> immobilized on bipyridine-based periodic mesoporous organosilica is a good catalyst for <italic>N</italic>-formylation of amines with CO<sub>2</sub> and PhSiH<sub>3</sub>.