gebhart/patrepeval huggingface dataset:
Frequency-hopping multiple-access communications with concatenated diversity/Reed-Solomon coding (1989)

Multiple-access capability of a frequency-hopped spread-spectrum communication system employing the concatenated diversity/Reed-Solomon code is investigated. We present general asymptotic expressions for the achievable region and the normalised throughput. For the case of finite block length codes, a fairly accurate approximation to the achievable region, subjected to the constraint that the packet error on a given link is no greater than P∩E, has been derived. Both side information and no side information cases are considered.
Vardenafil Modulates Bladder Contractility Through cGMP-mediated Inhibition of RhoA/Rho Kinase Signaling Pathway in Spontaneously Hypertensive Rats (2009)

This is the first study demonstrating that the effect of vardenafil on OAB could be partially determined by a cGMP-dependent RhoA/ROCK signaling inhibition.
Tuning of the pitch height of thermotropic cellulose esters (2000)

Butyric esters of (2-hydroxypropyl) cellulose (BuPC) with different degree of substitution (DS) were synthesized via control of the esterification time of butyryl chloride and (2-hydroxypropyl) cellulose. These BuPCs are thermotropic and displayed different colors at ambient temperature due to the formation of a cholesteric structure and the occurrence of a corresponding cholesteric reflection. The pitch height was found to increase significantly with a decrease of the degree of substitution. Both the glass transition temperature and the melting temperature are not affected by variation of the DS. The BuPC samples displayed a banded texture or focal-conic texture, respectively. The X-ray diffraction studies revealed the presence of a layer structure. The d-spacing between two adjacent layers in the cholesteric structure displayed no significant dependence on the DS in the range from 2 to 3.
Phosphorylation of mononucleotides and formation of cytidine 5'-diphosphate-choline and sugar nucleotides by respiration-deficient mutants of yeasts (1976)

Respiration-deficient mutants (Rho-, petite) of Saccharomyces carlsbergensis were obtained by treatment with trypaflavin (euflavine). Dried cells of these mutants phosphorylated mononucleotides to their triphosphates and further formed not only cytidine 5'-diphosphate-choline, but also sugar nucleotides, such as uridine 5'-diphosphate-glucose, guanosine 5'-diphosphate-mannose, etc. The activities were the same or slightly greater than those of the wild strain. These results showed that energy (adenosine 5'-triphosphate) necessary for phosphorylation of mononucleotides was sufficiently supplied by the glycolysis system.
ChemInform Abstract: Selective, Heterogeneous Oxidation of Alcohols and Diols with Potassium Permanganate. (1988)

Abstract Oxidation of the alcohols (I) or the diols (III) and (V) with solid KMnO4/CuSO4·5H 2 O in the presence or absence of a base yields the acids (II) or the lactones (IV) and (VI).
Modeling of stress-retarded orientation-dependent oxidation: shape engineering of silicon nanowire channels (2009)

A new universal stress retardation parameter set is successful to account for initial oxidation rate enhancement, orientation-dependent retardation and self-limiting phenomena observed in the dry oxidation experiment of the silicon FIN nanostructures over a wide temperature range. This stress-retarded orientation-dependent model was proved to be trustworthy in shape engineering of silicon nanowire channels.
Low Latency Communication on DIMMnet-1 Network Interface Plugged into a DIMM Slot (2002)

DIMMnet-1 is a high performance network interface for PC clusters that can be directly plugged into the DIMM slot of a PC. By using both low latency AOTF (Atomic On-The-Fly) sending and high bandwidth BOTF (Block On-The-Fly) sending, it can overcome the overhead caused by standard I/O such as the PCI bus. Two types of DIMMnet-1 prototypeboards (providing optical and electrical network interfaces) containing a Martini network interface controller chip are currently available. They can be plugged into a 100MHz DIMM slot of a PC with a Pentium-3, Pentium-4 or Athlon processor. The round-trip time for AOTF onthis incompletely tuned DIMMnet-1 is 7.5 times faster than Myrinet2000. The barrier synchronization time for AOTF is 4 times faster than that of an SR8000 supercomputer. Theinter-two-node floating sum operation time is 1903 ns. This shows that DIMMnet-1 holds promise for applications in which scalable performance with traditional approaches is difficult because of frequent data exchange.
Novel Autosomal Recessive Splice-Altering Variant in PRKD1 Is Associated with Congenital Heart Disease (2021)

Congenital heart defects (CHDs) are the most common types of birth defects, and global incidence of CHDs is on the rise. Despite the prevalence of CHDs, the genetic determinants of the defects are still in the process of being identified. Herein, we report a consanguineous Saudi family with three CHD affected daughters. We used whole exome sequencing (WES) to investigate the genetic cause of CHDs in the affected daughters. We found that all affected individuals were homozygous for a novel splice-altering variant (NM_001330069.1: c.265-1G>T) of <i>PRKD1</i>, which encodes a calcium/calmodulin-dependent protein kinase in the heart. The homozygous variant was found in the affected patients with Pulmonary Stenosis (PS), Truncus Arteriosis (TA), and Atrial Septal Defect (ASD). Based on the family's pedigree, the variant acts in an autosomal recessive manner, which makes it the second autosomal recessive variant of <i>PRKD1</i> to be identified with a link to CHDs, while all other previously described variants act dominantly. Interestingly, the father of the affected daughters was also homozygous for the variant, though he was asymptomatic of CHDs himself. Since both of his sisters had CHDs as well, this raises the possibility that the novel <i>PRKD1</i> variant may undergo autosomal recessive inheritance mode with gender limitation. This finding confirms that CHD can be associated with both dominant and recessive mutations of the <i>PRKD1</i> gene, and it provides a new insight to genotype-phenotype association between <i>PRKD1</i> and CHDs. To our knowledge, this is the first report of this specific <i>PRKD1</i> mutation associated with CHDs.
A low-latency and bandwidth-efficient distributed optical burst switching architecture for metro ring (2004)

Optical burst switching (OBS) provides statistical multiplexing capabilities at the optical layer with relaxed hardware requirements when compared to optical packet switching. One of the open challenges of OBS is to assemble as many packets as possible in the same burst, while at the same time ensuring low latency of the transmitted packets. The authors propose the use of OBS to realize a geographically distributed packet switch for metro rings. High efficiency of the ring bandwidth and low packet latency are obtained at the ring node by combining a multi-token based protocol for contention less and loss-free transmission of bursts, known as the lightring protocol, with the creation of bursts that contain packets belonging to multiple traffic flows (classified by priority and destination). As illustrated in the paper, the proposed solution yields throughput that is significantly higher than that one offered by a centralized packet switch connected to the ring nodes via dedicated optical circuits. Latency of real time packets is kept at few dozens of milliseconds under a variety of network scenarios. The solution scales well geographically for metro applications.
Of Mechanism Design Multiagent Planning (2008)

Multiagent planning methods are concerned with planning by and for a group of agents. If the agents are self-interested, they may be tempted to lie in order to obtain an outcome that is more rewarding for them. We therefore study the multiagent planning problem from a mechanism design perspective, showing how to incentivise agents to be truthful. We prove that the well-known truthful VCG mechanism is not always truthful in the context of optimal planning, and present a modification to fix this. Finally, we present some (domain-dependent) poly-time planning algorithms using this fix that maintain truthfulness in spite of their non-optimality.
A new series of amphiphilic molecules forming stable Z-type (polar) Langmuir-Blodgett films (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new series of amphiphilic molecules forming stable Z-type (polar) Langmuir-Blodgett filmsR. Popovitz-Biro, K. Hill, E. Shavit, D. J. Hung, Meir Lahav, L. Leiserowitz, J. Sagiv, H. Hsiung, G. R. Meredith, and H. VanherzeeleCite this: J. Am. Chem. Soc. 1990, 112, 7, 2498–2506Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://doi.org/10.1021/ja00163a005RIGHTS & PERMISSIONSArticle Views353Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Analysis Multispectral Image Capture (1996)

Multispectral image capture (i.e, more than three channels) facilitates both more accurate tristimulus estimation and possibilities for spectral reconstruction of each scene pixel. A seven-channel camera was assembled using approximately 50 nm bandwidth interference filters, manufactured by Melles Griot, in conjunction with a Kodak Professional DCS 200m digital camera. Multichannel images were recorded for the Macbeth ColorChecker chart as an illustrative example. Three methods of spectral reconstruction were evaluated: spline interpolation, modified-discrete-sine-transformation (MDST) interpolation, and an approach based on principal-component analysis (PCA). The spectral reconstruction accuracy was quantified both spectrally and by computing CIELAB coordinates for a single illuminant and observer. The PCA-based technique resulted in the best estimated spectral-reflectance-factor functions. These results were compared with a least-squares colorimetric model that does not include the spectral-reconstruction step. This direct mapping resulted in similar colorimetric performance to the PCA method. The multispectral camera had marked improvement compared with traditional three-channel devices.
An update on sarcoidosis-associated pulmonary hypertension (2020)

Several registries have highlighted SAPH portends an unfavorable consequence. On the contrary, no published guideline exists to treat SAPH. The precise role of immunosuppressive agents is unclear. The limited evidence favoring use of pulmonary vasodilators arise from small retrospective case series and/or single-center nonrandomized observational studies. Further multicenter randomized research is warranted to better define patient population to treat and how best to treat them.
Combined Photon Pair Generation and Quantum Walks in Quadratic Nonlinear Waveguide Arrays (2011)

We study photon pair generation through spontaneous parametric down conversion accompanied by quantum walks in arrays of quadratic nonlinear waveguides and investigate various ways to control output photon correlations.
Editors' Introduction (1974)

This issue of Soviet Education is the second of two issues made up of papers originally delivered at the First Scientific Conference of Pedagogical Scholars of Socialist Countries (Moscow, 1971) and published in 1973 in the Russian book, Problems of Socialist Pedagogy. * Last month's issue presented selections from the first section of the book dealing with the methodology of educational research. The six papers in this issue are taken from the second section of the book, "Education and the Scientific-Technological Revolution."
Predicting the Next Location: A Recurrent Model with Spatial and Temporal Contexts (2016)

Spatial and temporal contextual information plays a key role for analyzing user behaviors, and is helpful for predicting where he or she will go next. With the growing ability of collecting information, more and more temporal and spatial contextual information is collected in systems, and the location prediction problem becomes crucial and feasible. Some works have been proposed to address this problem, but they all have their limitations. Factorizing Personalized Markov Chain (FPMC) is constructed based on a strong independence assumption among different factors, which limits its performance. Tensor Factorization (TF) faces the cold start problem in predicting future actions. Recurrent Neural Networks (RNN) model shows promising performance comparing with PFMC and TF, but all these methods have problem in modeling continuous time interval and geographical distance. In this paper, we extend RNN and propose a novel method called Spatial Temporal Recurrent Neural Networks (ST-RNN). ST-RNN can model local temporal and spatial contexts in each layer with time-specific transition matrices for different time intervals and distance-specific transition matrices for different geographical distances. Experimental results show that the proposed ST-RNN model yields significant improvements over the competitive compared methods on two typical datasets, i.e., Global Terrorism Database (GTD) and Gowalla dataset.
An osteonectinlike protein in porcine periodontal ligament and its synthesis by periodontal ligament fibroblasts (1984)

Periodontal ligament, a soft connective tissue that lies between cementum and alveolar bone in the periodontium, has been shown to contain an osteonectinlike protein. The similarity between porcine ligament osteonectin and bovine bone osteonectin was evident from immunochemical studies, from migration characteristics on sodium dodecyl sulfate - polyacrylamide gel electrophoresis (SDS-PAGE) and from binding studies on hydroxyapatite. Using immunotransfer and immunodot analyses, ligament osteonectin was found to be extractable from tissues with 4 M guanidine-HCl (GuHCl) and 4 M GuHCl - 0.5 M EDTA and to comigrate with authentic bovine osteonectin on SDS-PAGE with a relative mass approximately 38 000. Furthermore, osteonectin from guanidine extracts of ligament was bound to hydroxyapatite in the presence of 4 M GuHCl. Immunofluorescence studies showed the osteonectin to be distributed throughout the extracellular matrix of the ligament and to be present within the ligament fibroblasts in a perinuclear, punctate distribution. Biosynthesis of osteonectin by ligament fibroblasts was studied following pulse-chase labelling with [35S]methionine and immunoprecipitation. The labelled osteonectin in the chased culture medium represented approximately 0.5% of the total labelled proteins secreted. It comigrated on SDS-PAGE with the corresponding labelled protein from pulsed cells and with the protein extracted from the tissue.
Attribute-Based Access Control (2015)

Attribute-based access control (ABAC) is a flexible approach that can implement AC policies limited only by the computational language and the richness of the available attributes, making it ideal for many distributed or rapidly changing environments.
Peltophorum Africanum, a Traditional South African Medicinal Plant, Contains an Anti HIV-1 Constituent, Betulinic Acid (2009)

The biodiversity of medicinal plants in South Africa makes them rich sources of leading compounds for the development of novel drugs. Peltophorum africanum (Fabaceae) is a deciduous tree widespread in South Africa. The stem bark has been traditionally employed to treat diarrhoea, dysentery, sore throat, wounds, human immunodeficiency virus/ acquired immune deficiency syndrome (HIV/AIDS), venereal diseases and infertility. To evaluate these ethnobotanical clues and isolate lead compounds, butanol and ethyl acetate extracts of the stem bark were screened for their inhibitory activities against HIV-1 using MAGI CCR5+ cells, which are derived from HeLa cervical cancer cells and express HIV receptor CD4, a chemokine receptor CCR5 and HIV-LTR-beta- galactosidase. Bioassay-guided fractionation using silica gel chromatography was also conducted. The ethyl acetate and butanol extracts of the stem bark of Peltophorum africanum showed inhibitory activity against HIV-1, CXCR4 (X4) and CCR5 (R5) tropic viruses. The ethyl acetate and butanol extracts yielded previously reported anti-HIV compounds, (+)-catechin, a flavonoid, and bergenin, a C-galloylglycoside, respectively. Furthermore, we identified betulinic acid from the ethyl acetate fraction for the first time. The fractions, which contained betulinic acid, showed the highest selective index. We therefore describe the presence of betulinic acid, a not well-known anti-HIV compound, in an African medicinal herb, which has been used for therapy, and claim that betulinic acid is the predominant anti-HIV-1 constituent of Peltophorum africanum. These data suggest that betulinic acid and its analogues could be used as potential therapeutics for HIV-1 infection.
Abstract 1710: DKN-01, a therapeutic DKK1 neutralizing antibody, has immune modulatory activity in nonclinical tumor models (2018)

Abstract Wnt signaling is a fundamental pathway that is dysregulated in oncology. The Wnt signaling modulator DKK1 is expressed in a variety of tumor types and elevated levels frequently correlate with poor survival. DKK1 promotes tumor growth by stimulating proliferation, metastasis, and angiogenesis, and has been implicated in contributing to an immune suppressive tumor microenvironment. DKN-01 is a humanized monoclonal therapeutic antibody that binds DKK1 with high affinity and selectivity. It is currently being evaluated clinically as a monotherapy and in combination in a variety of solid tumors. Here we describe further characterization of the mechanism of action of DKN-01 and demonstrate immune mediated anti-tumor activity in nonclinical models. A murine version of DKN-01 (mDKN-01) has efficacy in a syngeneic melanoma B16 tumor model. However, mDKN-01 is unable to impede B16 tumor growth in NSG immunodeficient mice, indicating that a functioning immune system is required for antibody activity. Furthermore, preliminary data suggest that mDKN-01 is targeting a myeloid derived suppressor cell population in the tumor microenvironment. These data support an immune mediated mechanism of action of DKN-01 and provide a rationale for clinical development in combination with immunotherapy agents. The first clinical study evaluating DKN-01 in combination with pembrolizumab has initiated enrollment in patients with relapse/refractory esophagogastric malignancies. Citation Format: Michael Haas, Heidi Heath, Yinyuan Wu, Xinjun Zhang, Cynthia Sirard, Xi He, Walter Newman, Michael Kagey. DKN-01, a therapeutic DKK1 neutralizing antibody, has immune modulatory activity in nonclinical tumor models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1710.
Natural IgM Antibodies in Baby Rabbit Serum Bind High-Mannose Glycans on HIV Type 1 Glycoprotein 120/160 and Activate Classic Complement Pathway (1998)

Serum from rodents and felines has been found very effective in complement-dependent lysis of HIV-1, even in nonimmunized animals, but the effector molecules in animal serum and target structures on HIV-1 envelope gp120/160 responsible for complement activation were not determined. We have found that the natural anti-carbohydrate-specific IgM antibodies present in baby rabbit serum were able to lyse effectively the CD4+ T cells coated with the whole virus or with a recombinant gp120/160, irrespectively of the virus strain or glycoprotein expression system. When the high mannose-type glycans on gp160 were enzymatically removed by endoglycosidase F or blocked with the specific lectins, the complement activation and subsequent cell lysis were abolished. IgM-depleted baby rabbit serum was not able to lyse the gp120/160- and/or whole virus-coated target cells. These results suggest that the target structures for complement-activating and naturally occurring IgM antibodies in baby rabbit serum are high-mannose residues on HIV-1 envelope glycoprotein.
ChemInform Abstract: Palladium‐Catalyzed α‐Arylation of 2‐Chloroacetates and 2‐Chloroacetamides. (2013)

Abstract The versatile scalable title reaction proceeds without using any strong bases or large excess of organometallic reagent.
Cyanoalkylation: Alkylnitriles in Catalytic CC Bond‐Forming Reactions (2015)

Alkylnitriles are one of the most ubiquitous nitrogen-containing chemicals and are widely employed in reactions which result in nitrile-group conversion into other functionalities. Nevertheless, their use as carbon pronucleophiles in carbon-carbon bond-forming reactions has been hampered by difficulties associated mainly with the catalytic generation of active species, that is, α-cyano carbanions or metalated nitriles. Recent investigations have addressed this challenge and have resulted in different modes of alkylnitrile activation. This review illustrates these findings, which have set the foundation for the development of practical and conceptually new catalytic, direct cyanoalkylation methodologies.
Catalytic intermediates in the Ag–O2 system. Evidence for a nonsymmetric AgO2 molecule (1982)

Matrix isolated infrared spectra of AgO2 in Ar matrices is presented and a normal coordinate analysis of AgO2 is performed. (AIP)
jLISP: An Open, Modular, and Extensible Java-Based LISP Implementation (2016)

LISP is a standardized overlay protocol implementing the locator/identifier split for the Internet. Multiple extensions exist, e.g., for NAT traversal, traffic engineering, etc. Existing LISP implementations are mostly platform-specific, hard to extend or they are closed source. In this work we present a Java-based implementation for LISP which is open source, modular, and features a plugin mechanism that enables simple integration of new functionality. It provides behavior for LISP nodes, infrastructure nodes, and various extensions, it is easily portable, can be run on various operating systems and platforms, in particular on Android smartphones. The demo illustrates LISP-based communication including the extensions mentioned above. In addition, the extensibility is demonstrated by a plugin for a statistics application.