gebhart/patrepeval huggingface dataset:
Loss of adipocyte-type fatty acid binding protein and other protein biomarkers is associated with progression of human bladder transitional cell carcinomas. (1996)

Multifocal recurrent papillary tumors provide a unique model system to study the molecular mechanisms underlying the steps involved in transitional cell carcinoma progression and offer a valuable source of material to search for biomarkers that may form the basis for diagnosis, prognosis, and treatment. We have examined the protein expression profiles of normal bladder urothelium and of 63 transitional cell carcinomas of various histopathological grades and T stages using high-resolution, two-dimensional gel electrophoresis, microsequencing, mass spectrometry, and a two-dimensional gel protein database approach for polypeptide identification (http://biobase.dk/cgi-bin/celis). In general, the results revealed a striking similarity between the overall qualitative expression patterns of papillary tumors of all grades, as well as of papillary and solid tumors of grade III. With few exceptions, tumors of grades I-III expressed, albeit at different levels, all of the keratins (7, 8, 13, 17, 18, 19, and 20) found in the normal urothelium. Grade IV tumors lacked or expressed reduced levels of keratin 13 but most resembled low-grade tumors. One invasive grade IV tumor, however, expressed a fibroblast-like protein phenotype. Four proteins that were expressed by normal urothelium and were lost at various stages of progression were identified as glutathione S-transferase mu, prostaglandin dehydrogenase (PGDH), a fatty acid binding protein with homology to the adipocyte isoform (A-FABP), and keratin 13. The percentage of tumors expressing A-FABP was very high in low-grade lesions but decreased drastically (P = 0.0006) in grade III and IV neoplasms. In addition, low-grade tumors contained more A-FABP than their high-grade counterparts. The stage of the disease was also statistically (P = 0.0269) related to the presence or absence of A-FABP in grade III tumors. Similar analysis of glutathione S-transferase mu and PGDH showed a statistically significant decrease of these proteins in high-grade (grades III and IV) tumors (P = 0.0026 and P = 0.0044, respectively). Only PGDH showed a suggestive correlation (P = 0.0775) with the stage of the disease in grade III tumors. Keratin 13 showed a drastic decrease in grade IV tumors. In addition to identifying biomarkers that may have prognostic value, our studies have suggested that A-FABP is an important component of the pathway(s) leading to bladder cancer development.
Characteristics of Boron in 4H-SiC Layers Produced by High-Temperature Techniques (2002)

Characteristics of boron in as-grown 4H-SiC layers produced by fast epitaxy, i.e. sublimation and vertical hot-wall CVD, were studied by electrical and optical measurements. The boron-related contribution to the net acceptor concentration in the layers (as determined by CV on p-type residual doped sublimation epitaxy layers), the presence of deep boron centers (as indicated by DLTS) and boron-related green emission at similar to 505 nm (as observed by CL) are detected for various growth temperatures and C/Si ratios. The results are discussed in relation with the C vacancies in the lattice that may be affected by growth rate and input C/Si ratio in the CVD process.
Retracted: Immersive Representation of Objects in Virtual Reality Environment Implementing Impicit Properties (2011)

In this work we propose a new concept of so called implicit (or "hidden") properties implemented in material object models. These are some features of the material object model that cannot be perceived by the observer through his/her senses (i.e. magnetization, radiation, humidity). Exploration of such features requires additional means and techniques that expand the perception range of the observer's different sensory channels. Traditional approaches use only a few of the explicit properties of objects models (mainly its geometric, structural and topological characteristics) for their building. We believe that the supplement of implicit properties, the selection of an appropriate combination of stimuli for separate sensory channels, their effective presentation to the observer and the ability for their modification directly in the virtual world will turn this situation in a way that may lead to a disruption in the generally accepted practices for different research fields, thus allowing for the virtual reality to unfold its full potential as a significant engineering design tool. Respectively, this will considerably enhance and intensify the information perception of the observer during object exploration in the virtual environment. Here, a brief introduction in the Virtual Reality and its engineering application is presented. The concepts about the material objects and their properties, as well as systems and norms for standardized properties sets and classes, have been surveyed. The developed Aura-Dowsing interaction technique as a part of ongoing complex research on the possibility for implementation of the implicit properties concept is presented and discussed.
Imaging of Cancer Immunotherapy: Current Approaches and Future Directions (2018)

Cancer immunotherapy using immune-checkpoint inhibitors has emerged as an effective treatment option for a variety of advanced cancers in the past decade. Because of the distinct mechanisms of immunotherapy that activate the host immunity to treat cancers, unconventional immune-related phenomena are encountered in terms of tumor response and progression, as well as drug toxicity. Imaging plays an important role in objectively characterizing immune-related tumor responses and progression and in detecting and monitoring immune-related adverse events. Moreover, emerging data suggest a promise for molecular imaging that can visualize the specific target molecules involved in immune-checkpoint pathways. In this article, the background and current status of cancer immunotherapy are summarized, and the current methods for imaging evaluations of immune-related responses and toxicities are reviewed along with their limitations and pitfalls. Emerging approaches with molecular imaging are also discussed as a future direction to address unmet needs.
Feasibility Study on a New Energy Harvesting Electromagnetic Device Using Aerodynamic Instability (2009)

Energy harvesting systems convert ambient energy from environment such as vibration, sunlight, wind, temperature gradient, etc. into electrical energy. Among several ambient energy sources, wind energy can be considered as one of the most promising sources because of its attractive features such as efficiency and economic merit. However, if an ordinary type of wind turbine is used for providing the electricity to low-power equipments (e.g., light poles, wireless sensors for structural health monitoring, etc.), it might be too inefficient and too costly. Recently, on the other hand, alternative (or innovative) approaches for wind power systems have been investigated by focusing on the aerodynamic instability phenomena such as galloping, flutter and vortex shedding. This paper first proposes a new energy harvesting system using wake galloping. To this end, the energy harvesting system based on wake galloping is designed and manufactured. And then, a series of wind tunnel tests are carried out in order to validate the efficiency and effectiveness of the proposed energy harvesting device. From these tests, the applicability of the proposed energy harvesting system using aerodynamic instability (i.e., wake galloping) is experimentally verified. Therefore, it can be an efficient energy harvesting system. Moreover, it can be used as an alternative energy source for low-power equipment, resulting in much simpler structural health monitoring systems without batteries for wireless sensors.
Space-time-coded reconfigurable card-to-card optical interconnects with broadcast capability (2017)

A space-time coded reconfigurable card-to-card freespace optical interconnect with broadcast capability is proposed and experimentally demonstrated. Results show that the broadcast function can be realized and the space-time-coding can extend the interconnection range by >45%.
Active and durable R2MnRuO7 pyrochlores with low Ru content for acidic oxygen evolution (2023)

The production of green hydrogen in water electrolyzers is limited by the oxygen evolution reaction (OER). State-of-the-art electrocatalysts are based on Ir. Ru electrocatalysts are a suitable alternative provided their performance is improved. Here we show that low-Ru-content pyrochlores (R<sub>2</sub>MnRuO<sub>7</sub>, R = Y, Tb and Dy) display high activity and durability for the OER in acidic media. Y<sub>2</sub>MnRuO<sub>7</sub> is the most stable catalyst, displaying 1.5 V at 10 mA cm<sup>-2</sup> for 40 h, or 5000 cycles up to 1.7 V. Computational and experimental results show that the high performance is owed to Ru sites embedded in RuMnO<sub>x</sub> surface layers. A water electrolyser with Y<sub>2</sub>MnRuO<sub>7</sub> (with only 0.2 mg<sub>Ru</sub> cm<sup>-2</sup>) reaches 1 A cm<sup>-2</sup> at 1.75 V, remaining stable at 200 mA cm<sup>-2</sup> for more than 24 h. These results encourage further investigation on Ru catalysts in which a partial replacement of Ru by inexpensive cations can enhance the OER performance.
Large converse magnetoelectric coupling in FeCoV/lead zinc niobate-lead titanate heterostructure (2009)

Multiferroic behavior was directly verified in a laminated ferroelectric-ferromagnetic heterostructure consisting of a FeCoV thick film (70 μm) and lead zinc niobate-lead titanate (PZN-PT) single crystal. This unique heterostructure demonstrates a significant converse magnetoelectric (CME) effect corresponding to a CME coupling constant of 31 Oe/kV cm−1. It derives from the soft magnetic and magnetostrictive properties (λ=60 ppm) of FeCoV alloy and the superior electromechanical properties (d32=−2800 pC/N) of PZN-PT crystal. The electric field controlled magnetic hysteresis is discussed in terms of a stress-induced anisotropy field model. The theoretical calculation is within 7% of the measured induced field of 240 Oe.
Thermally and electron‐impact‐induced rearrangements of dimethylthioncarbamates in gaseous phase (1972)

Abstract The thermally and electron‐impact‐induced rearrangements of the dimethylthioncarbamates to the dimethylthiolcarbamates are discussed. Owing to the competition with the ion fragmentation reactions in the mass spectrometric time, &lt; 10 −6 seconds, the extent of the mass spectrometrically observed ion isomerization cannot be predicted from that of the thermal induced one. In the ion fragmentations of the non‐rearranged molecular ions, it was found that the relative abundance of the ion (CH 3 ) 2 NCO ⊕ to the total ionization is larger than that of the ion (CH 3 ) 2 NCS ⊕ . This is believed to be attributable to the differences in the dissociation energies of the CS bond and the CO bond and in the stabilities of the two ions.
Pulsed Electric Field Alters Molecular Chaperone Expression and Sensitizes Listeria monocytogenes to Heat (2004)

Pulsed electric field (PEF)-resistant and PEF-sensitive Listeria monocytogenes strains were sublethally treated with electric pulses at 15 kV/cm for 29 micro s and held at 25 degrees C for 5 to 30 min prior to protein extraction. The levels of the molecular chaperones GroEL, GroES, and DnaJ were determined by immunoblotting. After 10 to 20 min after sublethal PEF treatment, a transient decrease in molecular chaperone expression was observed in the PEF-sensitive strain (Scott A). The levels of GroEL and DnaJ increased back to the basal expression level within 30 min. A substantial decrease in GroES expression persisted for at least 30 min after PEF treatment. Chaperone expression was suppressed after PEF treatment to a smaller extent in the PEF-resistant (OSY-8578) than in the PEF-sensitive strain, and no clear expression pattern was identified in OSY-8578. Inactivation of Scott A and OSY-8578 in phosphate buffer was compared when lethal PEF (27.5 kV/cm, 144 micro s) and heat (55 degrees C, 10 min) were applied in sequence. When PEF and heat treatments were applied separately, the populations of L. monocytogenes Scott A and OSY-8578 decreased 0.5 to 0.6 log CFU/ml. Cells treated first with PEF and incubated at 25 degrees C for 10 min showed substantial sensitivity to subsequent heat treatment; the decrease in counts for Scott A and OSY-8578 was 6.1 and 2.8 log CFU/ml, respectively. The sequence and time lapse between the two treatments were crucial for achieving high inactivation rates. It is concluded that PEF sensitized L. monocytogenes to heat and that maximum heat sensitization occurred when chaperone expression was at a minimum level.
Lip's movements biometric authentication in electronic devices (2017)

System authentication key is very sensitive and important part of today's smart and high technology system. Key contains the biometric information of the human body. Detection of the face, lip and lip movements are taken as the key for the system. In the whole process of authentication different phases are there which includes reading video file, framing, segmentation, removal of noise using median filter, classification of templates using hamming distance, recognition password, etc. Results are taken from offline stored videos. Results need improvement in terms of accuracy.
New carbazole-indan-1,3-dione- based host materials for phosphorescent organic light emitting diodes (2016)

New carbazole- and indan-1,3-dione -based low molecular weight derivatives were synthesized and characterized by mass spectrometry and 1H NMR spectroscopy. Thermal behaviour of the derivatives was demonstrated by thermo-gravimetric analysis and differential scanning calorimetry. The materials were found to show very high thermal stability having initial thermal degradation temperatures in the range of 398- 401°C. Glass transition temperatures of the amorphous molecular materials were in the rage of 80–114°C. The derivatives were tested as host materials in blue phosphorescent organic light emitting diodes with iridium(III)[bis(4,6-difluorophenyl)-pyridinato-N,C2′]picolinate as the guests. One of the blue OLED devices demonstrated rather low turn-on voltage of 5.0 V, a maximum luminance efficiency of 2.73 cd/A and maximum brightness of about 220 cd/m2.
The effect of patent acquisition on subsequent patenting activity (2019)

The importance of the patent market has increased in the high technology market due to open innovation and social efficiency. As most high-tech firms cannot rely on their own repository of technologies, they need to employ external technologies. These can be acquired through mergers and acquisitions (M&A) or from the patent markets, which is often referred to as open innovation. Because of insufficient comprehensive data and the complexity and contingency provision of the contract, there have been only a few empirical studies on patent transactions. This study seeks to understand the patenting activities of patent buyers after acquisition. By merging patent bibliographies and patent assignment information, the original dataset was prepared to investigate the patent acquisition activities of the patentees who were granted patents from 2007 to 2011 and their patent application activities from 2012 to 2016. The factors affecting patent production and acquisition and the relationship between patent acquisition and subsequent production were examined. The results show that the patent acquisition activity depends on the applicant type and technology field, and affects the future patent production of the applicant. Thus, observing a competitor's patent acquisition activities gives insights into the future direction of its technology development.
Functional Analysis of Proton‐Coupled Sucrose Transport (2017)

Abstract The sections in this article are Introduction Defining Basic Properties of Transport Intact Tissues Membrane Vesicles Sucrose Sensing Heterologous Expression Systems Sucrose Transport in Plant Growth and Development
Intracytoplasmic tagging of cells with ferumoxides and transfection agent for cellular magnetic resonance imaging after cell transplantation: methods and techniques (2003)

This technique can be used to label cells for in vivo MRI tracking of stem cells and lymphocytes. FE at a concentration of 25 to 50 microg/mL with a ratio of SPIO to PLL of 1:0.03 to 1:0.06 would be sufficient to label cells for cellular MRI.
AN ITALIAN'S MESSAGE TO ENGLAND IN 1614 (1938)

AbstractAbstractVisitors to England from the Latin countries in Elizabethan and early Stuart times were invariably amazed at the number and abundance of our daily meals, and went home<disp-quote>'Swearing all other nations eat far less Than Englishmen.'</disp-quote>
Relationship between Fatigue Strength and Grain Size in AZ31 Magnesium Alloys (2008)

The effects of the grain size on the fatigue fracture behaviors in extruded AZ31B alloys were investigated. The mean grain sizes are 4.7 μm in F-specimen, 15 μm in M-specimen and 23 μm in C-specimen, respectively. The fatigue tests with R=−1 were carried out with a plane fatigue bending machine, which was originally developed for thin sheet specimen. S-N curves show that the fatigue limit of the F-, the M- and the C-specimens were estimated as 160 MPa, 150 MPa and 150 MPa, respectively. The F-specimen had the highest fatigue limit in the present alloys. On the other hand, the fatigue life in low cycle region of the F-specimen is shorter than those of the M- and C-specimens. Striation-like-patterns were observed on the fracture surfaces in all of the specimens, although the grain sizes were different. Twin was not observed in the F-specimen, but it was near the crack in the C-specimen. Consequently, twinning under the fatigue test depends on the grain size, and it affects the fatigue life of AZ31B alloys.
Some bis(tert-butylimido) complexes of the Group 6 transition metals and a related alkylamido derivative (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome bis(tert-butylimido) complexes of the Group 6 transition metals and a related alkylamido derivativeWilliam A. Nugent and Richard L. HarlowCite this: Inorg. Chem. 1980, 19, 3, 777–779Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://pubs.acs.org/doi/10.1021/ic50205a041https://doi.org/10.1021/ic50205a041research-articleACS PublicationsRequest reuse permissionsArticle Views665Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: Synthesis of Lipid Derivatives of Colchicine. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
S3-06 SESSION 3: FACIOCRANIOSYNOSTOSIS – PART I SURFING THE BONE PRESSURE WAVE: CORRELATION OF CSF RATIO WITH CRANIAL DEFECT HEALING IN PFEIFFER PATIENTS REQUIRING EARLY INTERVENTION (2019)

Introduction: Timing of interventions in the first years of life is critical to achieving cephalo-cranial balance in patients with Pfeiffer syndrome. Decision-making in this crucial time can be ambiguous. The objective of this study was to quantify and track cranial defect surface area (DSA), optic nerve sheath diameter (ONSD) and cerebrospinal fluid ratio (CSFR) in a cohort of Pfeiffer patients undergoing early intervention for severe cranial dysmorphology. The goal was to be able to use this retrospective data to determine the role of these three measures in managing future cases. Methods: Six patients with Pfeiffer’s syndrome and severe cranial dysmorphology were analyzed. 104 scans were included at patient ages 0 to 10 years. We performed image analysis using custom program code on a Slicer platform to calculate automatically DSA and CSFR. ONSD was manually measured. Regression analysis was used to detect a correlation between the three measures. Results: There was no correlation between ONSD and the other two variables. There was a strong correlation, (R=0.61, p < 0.0001), between DSA and CSFR. The patterns of decreasing DSA and CSFR were linked on medical chart review with early ventriculo-peritoneal shunt (VPS) placement and monobloc distraction. Conclusion: Our findings are consistent with the concept of “surfing the bone-pressure wave”, where early surgeries such as monobloc and VPS can create cephalocranial balance by restoring CSFR, resulting in unimpaired cranial defect healing. We will track changes in DSA and CSFR in future Pfeiffer patients to aid in determining appropriate timing of these early interventions.
Molecular Identification of a Functional Homologue of the Mammalian Fatty Acid Amide Hydrolase in Arabidopsis thaliana (2003)

N-Acylethanolamines (NAEs) are endogenous constituents of plant and animal tissues, and in vertebrates their hydrolysis terminates their participation as lipid mediators in the endocannabinoid signaling system. The membrane-bound enzyme responsible for NAE hydrolysis in mammals has been identified at the molecular level (designated fatty acid amide hydrolase, FAAH), and although an analogous enzyme activity was identified in microsomes of cotton seedlings, no molecular information is available for this enzyme in plants. Here we report the identification, the heterologous expression (in Escherichia coli), and the biochemical characterization of an Arabidopsis thaliana FAAH homologue. Candidate Arabidopsis DNA sequences containing a characteristic amidase signature sequence (PS00571) were identified in plant genome data bases, and a cDNA was isolated by reverse transcriptase-PCR using Arabidopsis genome sequences to develop appropriate oligonucleotide primers. The cDNA was sequenced and predicted to encode a protein of 607 amino acids with 37% identity to rat FAAH within the amidase signature domain (18% over the entire length). Residues determined to be important for FAAH catalysis were conserved between the Arabidopsis and rat protein sequences. In addition, a single transmembrane domain near the N terminus was predicted in the Arabidopsis protein sequence, similar to that of the rat FAAH protein. The putative plant FAAH cDNA was expressed as an epitope/His-tagged fusion protein in E. coli and solubilized from cell lysates in the nonionic detergent, dodecyl maltoside. Affinity-purified recombinant protein was indeed active in hydrolyzing a variety of naturally occurring N-acylethanolamine types. Kinetic parameters and inhibition data for the recombinant Arabidopsis protein were consistent with these properties of the enzyme activity characterized previously in plant and animal systems. Collectively these data now provide support at the molecular level for a conserved mechanism between plants and animals for the metabolism of NAEs.