gebhart/patrepeval huggingface dataset:
Adenomatoid Tumor of the Uterus: A Light and Electron Microscopic Study of Two Cases (1984)

Abstract Two cases of adenomatoid tumors of the uterus were studied by light and electron microscopy. Light microscopy revealed that the lesions consisted of two distinct histologic components, one glandular and the other plexiform. The glandular areas contained various sized lumina that were lined by a single layer of cuboidal cells, and the plexiform portions were comprised of spindle‐shaped cells in solid cords. Ultrastructurally, the glandular tissue consisted of mesothelial‐like cells which were characterized by numerous microvilli, desmosomes, and basal lamina. The mesenchymal‐like cells in the plexiform areas also had microvilli, however in this material the microvilli protruded toward the surrounding stroma. These latter cells were observed solitarily or in groups with narrow intercellular spaces. These electron microscopic findings suggested a biphasic nature of adenomatoid tumors, epithelial and mesenchymal. In addition, we observed spindle‐shaped cells which may have been undergoing a transition from mesenchymal‐like cells into mesothelial‐like cells in the mingled forms of both the glandular and plexiform components. This finding may imply that mesenchymal cells possibly differentiate into mesothelial‐like cells in adenomatoid tumors.
Hybrid model for preserving brightness over the digital image processing (2013)

Digital image processing is versatile research in this era. Many researchers implement different types of organizations like image restoration, image enhancement, color image processing, image segmentation etc. Image enhancement technique is among the simplest and most appealing area of digital image processing. Enhancement techniques like brightness preservation, contrast enhancement highlight certain features means depend which part of the image want to be enhance some application some input image including noise, reduction or removal of noise is also form of image enhancement. Brightness preservation has enhanced visual quality of digital image so that the limitation contained in these images is used for various applications in a better way. A very popular technique for image enhancement is histogram equalization (HE) and curvelet transformation. HE technique is commonly employed for image enhancement because of its simplicity and comparatively better performance on almost all types of images. Another widely used technique is curvelet transformation. This technique is identified and separate bright regions of image but more error rate and low peak signal to noise ratio(PSNR), result of this technique is brightness preservation level is low and output image is gray. This paper design a hybrid model through discrete cosine transformation, discrete wavelet transformation and combine output of both techniques with image fusion. Proposed algorithm enhanced features and removal noise by decomposition of image using DWT and discrete cosine transformation, adaptive histogram equalization is very important part in this algorithm for smooth image. The tested results of different images are comparing with previous method, generating result with different parameters; less mean square error and high PSNR for improve the quality of an image. This paper presents a hybrid model used various parameter for enhance images like satellite images, medical images etc.
Identification of the first nonsenseCDSNmutation with expression of a truncated protein causing peeling skin syndrome type B (2013)

These results are interesting regarding the genotype-phenotype correlations in diseases caused by CDSN mutations. The PSD-causing CDSN mutations identified heretofore result in total corneodesmosin loss, suggesting that PSD is due to full corneodesmosin deficiency. Here, we show for the first time that a mutant corneodesmosin can be stably expressed in some patients with PSD, and that this truncated protein is very probably nonfunctional.
Proton-Coupled Sugar and Amino Acid Transporters in Plants (1993)

Crop loss due to soil salinization is an increasing threat to agriculture worldwide. This review provides an overview of cellular and physiological mechanisms in plant responses to salt. We place cellular responses in a time- and tissue-dependent context ...Read More
Urine-Derived Compound Evokes Membrane Responses in Mouse Vomeronasal Receptor Neurons (1997)

Sensory neurons of the vomeronasal organ (VNO) are thought to detect species-specific chemical signals important for reproductive function. The electrical properties of VNO neurons have begun to be characterized in a variety of species; however, the response of VNO neurons to possible physiological ligands has not yet been reported. One physiological effector, dehydro-exo-brevicomin (DHB), is found in the urine of intact male mice and affects the estrous cycle of female mice. In the present study, dissociated VNO neurons were voltage- or current-clamped and their response to DHB was determined. Approximately 26% of VNO neurons responded to DHB with an outward current at negative holding potentials; the current reversed at approximately +4 mV. Application of DHB in current-clamp mode produced membrane hyperpolarization and/or a reduction in the firing of action potentials. Because membrane conductance was shown to be decreased during application of DHB, the results suggest that the outward current associated with DHB application is a reflection of a reduction in inward current caused by closing an ion channel. This study provides the first evidence that a compound found in male urine directly affects VNO neurons.
Stress-Induced Mechanotransduction: Some Preliminaries (2003)

Mechanical stimuli affect nearly every aspect of cellular function, yet the underlying mechanisms of transduction of force into biochemical signals are not clearly understood. One hypothesis is that forces transmitted via individual proteins, either at the site of cell adhesion to its surroundings or within the stress-bearing members of the cytoskeleton, cause conformational changes that change their binding affinity to other intracellular molecules. This altered equilibrium state can subsequently initiate biochemical signaling cascades of produce immediate structural changes. This paper addresses the distribution of forces within the cell resulting from specific mechanical stimuli, computed using a 3-D multi compartment, continuum, viscoelastic finite element model, and uses these to estimate the forces transmitted by individual proteins and protein complexes. These levels of force are compared to those known to produce conformational changes in cytoskeletal proteins, as speculated from magnetocytometry observations and computed by molecular dynamics.
Synchronous motors for AC adjustable-speed drives (2002)

Many power engineers have struggled with ideas of standard and special synchronous motor designs as those concepts relate to LCI (load commutators inverter) drives. Today many engineers accept the premise that LCI motors belong in a category unto themselves, different from 'standard' synchronous motors. Some points of view bearing upon this theme are discussed. Operating principles, application methodologies and criteria, machine design, and field experience are reviewed. Some concepts of standard motor design are described and compared to corresponding aspects of LCI motor designs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Guerre préventive : mener la bataille en territoire ennemi (2003)

et de quelque manire que ce soit, est interdite sauf accord pralable et crit de l'diteur, en dehors des cas prvus par la lgislation en vigueur en France. Il est prcis que son stockage dans une base de donnes est galement interdit.
Electric control of state of polarization in index-guiding photonic liquid crystal fibers (2013)

Photonic liquid crystal fibers allow for dynamic modification of their guiding and polarization properties. In particular it is possible to dynamically tune phase delay between two orthogonal polarization of the guided mode. In this work an index-guiding photonic liquid crystal fiber with highly tunable retardation, reaching value of 15&lambda; (or 30&pi; in terms of phase difference) is presented. Electric tuning with two sets of electrodes is also discussed and demonstrated proving that photonic liquid crystal fibers can be utilized as a all-in-fiber polarization controllers.
Electrolyte Composition Influence on Oxygen Reduction and Evolution in Li-Air Cells (2016)

The lithium-air battery is a promising next generation energy storage technology, yet the current combinations of electrolytes and electrodes have been unable to demonstrate long-term efficient cell cycling. Major issues include the decomposition of electrode and electrolyte materials and high overpotentials for the oxidation reaction. While there is significant work exploring the possibility of catalyzed electrodes to reduce cell overpotentials and encourage reversibility, there is a lack of understanding about how to select appropriate complementary electrolyte systems. In this study we employ data from hundreds of Li-air cells to reveal meaningful relationships between electrolyte composition (solvent, salt, oxygen solubility and concentration), oxygen reduction kinetics and mass transport properties. Data from practical coin-type cells are compared to fundamental studies using flat disc electrodes to prove the validity of the method. Findings are supported by molecular dynamics simulations to elucidate the interaction of various electrolyte components. The relationships derived in this work form necessary criteria for downselecting electrolyte systems with the most desired properties. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy’s National Nuclear Security Administration under contract DE-AC04-94AL85000.
Heart Rate Variability and Baroreceptor Sensitivity in Acute Stroke: A Systematic Review (2015)

Cardiac autonomic dysfunction, represented by reduced heart rate variability or impaired baroreceptor sensitivity, is associated with stroke severity, early and late complications, dependency, and mortality. Large-scale prospective studies applying internationally accepted standards of measures for analysis of heart rate variability and baroreceptor sensitivity are needed in patients with acute stroke.
Ensemble-based Data Assimilation Methods for Viscoelastic Material Rheometry during Bubble Collapse (2019)

International audience
Procalcitonin and pulmonary aspiration: Another possible interpretation (2011)

The Veterans Affairs Western New York Healthcare System, Buffalo, NY; and Western New York Respiratory Research Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Departments of Medicine and Anesthesiology, Buffalo, NY
A Global Survey of ATPase Activity in Plasmodium falciparum Asexual Blood Stages and Gametocytes (2017)

Effective malaria control and elimination in hyperendemic areas of the world will require treatment of the <i>Plasmodium falciparum</i> (<i>Pf</i>) blood stage that causes disease as well as the gametocyte stage that is required for transmission from humans to the mosquito vector. Most currently used therapies do not kill gametocytes, a highly specialized, non-replicating sexual parasite stage. Further confounding next generation drug development against <i>Pf</i> is the unknown metabolic state of the gametocyte and the lack of known biochemical activity for most parasite gene products in general. Here, we take a systematic activity-based proteomics approach to survey the activity of the large and druggable ATPase family in replicating blood stage asexual parasites and transmissible, non-replicating sexual gametocytes. ATPase activity broadly changes during the transition from asexual schizonts to sexual gametocytes, indicating altered metabolism and regulatory roles of ATPases specific for each lifecycle stage. We further experimentally confirm existing annotation and predict ATPase function for 38 uncharacterized proteins. By mapping the activity of ATPases associated with gametocytogenesis, we assign biochemical activity to a large number of uncharacterized proteins and identify new candidate transmission blocking targets.
EFFECT OF TA ADDITION ON IRRADIATION RESISTANCE PROPERTIES OF AUSTENITIC STAINLESS STEELS FOR REACTOR PRESSURE VESSEL INTERNALS (2019)

In order to elevate the resistance against irradiation-assisted stress corrosion cracking (IASCC) of reactor pressure vessel internals (RINs) in the environment of boiling water reactor (BWR), austenitic stainless steels (SSs) with tantalum (Ta) addition have been examined. The oversized element Ta is considered to reduce the concentration of free vacancy due to trapping effect. It is expected that radiation-induced grain boundary (GB) segregation of constituent element such as chromium (Cr) can be suppressed by Ta addition. In this study the irradiation tests were performed with Fe2+ ion in a dose range from 0.1 to 3 dpa on the specimens sampled from base materials and heat-affected zone (HAZ) of welding joint plates. Considering the Cr segregation might also occur during the heat history of welding process, we first confirmed and discussed the effect of Ta addition to SUS310S on irradiation resistance properties in the HAZ. The radiationinduced segregation (RIS) on random GBs in HAZ after the irradiation tests was evaluated by scanning transmission electron microscope (STEM) and X-ray energy dispersive spectroscopy (XEDS). The improvement of resistance against RIS by Ta addition was evaluated. Further the effect of Ta addition on radiation induced hardening was investigated on the base materials, but from the results of nanoindentation test the obvious relief of radiation-induced hardening was not confirmed. The corrosion properties after heavy ion irradiation were also discussed on the base materials in the conditions of electrochemical potentiokinetic reactivation (EPR) test. GB corrosion was observed on the ion-irradiated surface of commercial material of SUS310S. However, no GB corrosion was observed on the irradiated surface of SUS310S with 0.4 % Ta addition, indicating the effect of Ta addition on the improvement of resistance against IASCC.
ItpkB regulates CCR7 expression on dendritic cells prior to lymph node trafficking (2016)

Abstract Dendritic cells (DC) are fundamental in the initiation of the adaptive immune response. Following antigen uptake, tissue-resident DCs undergo maturation in preparation for their migration to lymph nodes where they present processed antigen to T cells. Down-regulation of tissue-homing receptors and upregulation of lymphoid-homing receptors, including CCR7 is required for dendritic cell entry into afferent lymphatic vessels. CCR7 binding to its ligands, CCL19 and CCL21, provides the appropriate directional cues for DCs to traffic to lymph nodes. Although both maturation and migration of DCs have been extensively studied, it still remains unclear what signaling pathways are responsible for inducing CCR7 expression. We found that DCs deficient in inositol-trisphosphate 3-kinase B (ItpkB) express higher levels of CCR7. ItpkB-deficient BMDCs migrate to draining lymph nodes more efficiently in both competitive and noncompetitive environments compared to their wild-type counterparts. We have previously shown that ItpkB deficiency leads to enhanced Akt activation in NK cells. Western blot analysis showed that ItpkB-deficiency in DCs also leads to increased basal and LPS-induced Akt1 activation. To determine whether hyper-Akt activity is sufficient to trigger enhanced lymph node homing, we expressed two forms of constitutively active Akt1, Myr-Akt1 and Akt1 T308E, S473D, in wildtype DCs. Akt1 hyperactivity was sufficient to promote CCR7 expression but did not affect DC maturation. Our findings suggest that ItpkB regulates CCR7 expression on dendritic cells as they prepare to traffic to draining lymph nodes for the purpose of primary T cell responses.
CULTURE IN VITRO OF TISSUE FROM THE SILKWORM, BOMBYX MORI L (1956)

1. Ovarian tissue from Bombyx mori L. larvae about to pupate was cultured in Trager's (1935) salt solution and 10 per cent hemolymph, with indifferent results. Improvement of cultures was sought by modifying the culture medium. 2. To reduce the activity of the tyrosinase, hemolymph for culture medium was heated for 5 minutes at 60 degrees C., and the coagulated protein removed. 3. A physiological solution was formulated containing cations and amino acids as they occur normally in silkworm hemolymph. In both hanging-drop and small tube cultures use of this medium brought about increased cell number, improved cell appearance, more rapid mitoses, and longer life of cultures. 4. To the solution formulated from analyses, tryptophan, cystine, cysteine, malate, fumarate, succinate, and alpha-ketoglutarate were added after testing individually, resulting in improved growth in cultures. 5. Use of a silkworm egg extract prepared 4 to 5 days after acid treatment produced an increase in cell number. 6. In small roller tube cultures, when the new medium was changed twice a week, the cells spread over the walls of the tube in 4 or 5 days (Figs. 8 and 9), rapid mitoses were observed after 2 weeks, and transparent active cells were present at 3 weeks. Subculturing was not attempted.
Rediscovering the Isospecific Ring-Opening Polymerization of Racemic Propylene Oxide with Dibutylmagnesium (2017)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTRediscovering the Isospecific Ring-Opening Polymerization of Racemic Propylene Oxide with DibutylmagnesiumSwarup Ghosh, Henrik Lund, Haijun Jiao, and Esteban Mejía*View Author Information Leibniz Institute for Catalysis, University of Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany*E-mail [email protected] (E.M.).Cite this: Macromolecules 2017, 50, 3, 1245–1250Publication Date (Web):January 20, 2017Publication History Received24 August 2016Revised13 December 2016Published online20 January 2017Published inissue 14 February 2017https://pubs.acs.org/doi/10.1021/acs.macromol.6b01830https://doi.org/10.1021/acs.macromol.6b01830brief-reportACS PublicationsCopyright © 2017 American Chemical SocietyRequest reuse permissionsArticle Views1574Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Monomers,Oxides,Polymers,Ring-opening polymerization Get e-Alerts
Transition Metal-Oxide Free Perovskite Solar Cells Enabled by a New Organic Charge Transport Layer (2016)

Various electron and hole transport layers have been used to develop high-efficiency perovskite solar cells. To achieve low-temperature solution processing of perovskite solar cells, organic n-type materials are employed to replace the metal oxide electron transport layer (ETL). Although PCBM (phenyl-C61-butyric acid methyl ester) has been widely used for this application, its morphological instability in films (i.e., aggregation) is detrimental. Herein, we demonstrate the synthesis of a new fullerene derivative (isobenzofulvene-C60-epoxide, IBF-Ep) that serves as an electron transporting material for methylammonium mixed lead halide-based perovskite (CH3NH3PbI(3-x)Cl(x)) solar cells, both in the normal and inverted device configurations. We demonstrate that IBF-Ep has superior morphological stability compared to the conventional acceptor, PCBM. IBF-Ep provides higher photovoltaic device performance as compared to PCBM (6.9% vs 2.5% in the normal and 9.0% vs 5.3% in the inverted device configuration). Moreover, IBF-Ep devices show superior tolerance to high humidity (90%) in air. By reaching power conversion efficiencies up to 9.0% for the inverted devices with IBF-Ep as the ETL, we demonstrate the potential of this new material as an alternative to metal oxides for perovskite solar cells processed in air.
Oral Probiotic Microcapsule Formulation Ameliorates Non-Alcoholic Fatty Liver Disease in Bio F1B Golden Syrian Hamsters (2013)

The beneficial effect of a microencapsulated feruloyl esterase producing Lactobacillus fermentum ATCC 11976 formulation for use in non-alcoholic fatty liver disease (NAFLD) was investigated. For which Bio F1B Golden Syrian hamsters were fed a methionine deficient/choline devoid diet to induce non-alcoholic fatty liver disease. Results, for the first time, show significant clinical benefits in experimental animals. Examination of lipids show that concentrations of hepatic free cholesterol, esterified cholesterol, triglycerides and phospholipids were significantly lowered in treated animals. In addition, serum total cholesterol, triglycerides, uric acid and insulin resistance were found to decrease in treated animals. Liver histology evaluations showed reduced fat deposits. Western blot analysis shows significant differences in expression levels of key liver enzymes in treated animals. In conclusion, these findings suggest the excellent potential of using an oral probiotic formulation to ameliorate NAFLD.
PAX5 expression correlates with increasing malignancy in human astrocytomas. (1995)

Rearrangements concerning chromosome 9p are a late event in the progression of human astrocytic tumors to their most malignant form. The expression of PAX5, which maps to chromosome 9p13, was studied in primary human brain tumors of astrocytic origin. Whereas murine Pax5 is not expressed in the forebrain at any stage, PAX5 expression was increased in a range of astrocytomas (WHO grades II-IV) which originated in the forebrain. Expression of PAX5 was limited to those cells which also expressed the oncogenes myc, fos, or jun singularly or in combination. The epidermal growth factor receptor was highly expressed in glioblastoma multiform tumors in areas which were also highly PAX5 positive. We conclude that the missappropriate expression of PAX5 may aid in promoting the progression of astrocytomal malignancy.
Fractional Dimensionality of Weakly Localized Electrons in GaAs-Ga 0.7 Al 0.3 As Heterostructures (1993)

Temperature and magneto-resistance anomalies due to weak localization have been measured on GaAs-Ga0.7Al0.3As heterostructures under hydrostatic pressure. Using the hydrostatic pressure, we have been able to vary the disorder parameter kl by a factor of 20 in the same sample. Our data agree well with Shapiro-Abrahams considerations of a fractional dimensionality d = 2 + ε, with ε ≃ 0.25. Consequently, the system should exhibit a metal-non-metal transition at T = 0.
Advanced optical coatings of a segmented MEMS DM (2009)

The performance of microelectromechanical systems deformable mirrors (MEMS DMs) continues to improve in areas of stroke, open-loop positioning, actuator count, and drive electronics. However, a key area lacking in the development of these devices is good optical coatings suitable for a broad spectrum of applications and wavelengths. This paper discusses the progress Iris AO has made towards coating its MEMS DMs with gold, protected aluminum, protected silver, and dielectric coatings.