gebhart/patrepeval huggingface dataset:
Does International Business Accreditation Assure Quality Or Constrain Innovation (2017)

This paper employs textual analysis to investigate whether business school accreditation guidelines may be considered to facilitate innovation. We identify the relative dominance of concepts and themes within accreditation guidelines of the three primary international business school associations. They demonstrate a relative paucity of concepts broadly related to innovation and a lack of sustained attention to experimentation and transformation. The location of these concepts within the various themes suggests that innovation is generally associated with discipline-based research while concepts with lesser innovative connotations are associated with education. We conclude that dominant business school accreditation standards do not yet induce behavior that extends much beyond focusing on assuring quality based upon past performance and metrics aligned with guaranteeing similar future outcomes
Complete Nucleotide Sequence of the LE1 Prophage from the SpirocheteLeptospira biflexaand Characterization of Its Replication and Partition Functions (2005)

The first and, to date, only extrachromosomal circular replicon identified in the spirochete Leptospira is the LE1 prophage from Leptospira biflexa. The 74-kb LE1 genome has a GC content of 36%, which is similar to the GC content of Leptospira spp. Most of the 79 predicted open reading frames (ORFs) showed no similarities to known ORFs. However 21 ORFs appeared to be organized in clusters that could code for head and tail structural proteins and immunity repressor proteins. In addition, the pattern of gene expression showed that several LE1 genes are expressed specifically either in LE1 prophage or in L. biflexa late after infection. Since the LE1 prophage replicates autonomously as a circular replicon in L. biflexa, we were able to engineer an L. biflexa-Escherichia coli shuttle vector from a 5.3-kb DNA fragment of LE1 (Saint Girons et al., J. Bacteriol. 182:5700-5705, 2000), opening this genus to genetic manipulation. In this study, base compositional asymmetry confirms the location of the LE1 replication region and suggests that LE1 replicates via a bidirectional Theta-like replication mechanism from this unique origin. By subcloning experiments, the replication region can be narrowed down to a 1-kb region. This minimal replication region consists of a rep encoding a protein of 180 amino acids. Upstream from rep, putative partitioning genes, called parA and parB, were found to be similar to the par loci in Borrelia plasmids. A significant increase of plasmid stability in L. biflexa can be seen only when both parA and parB are present. These results enable the construction of new shuttle vectors for studying the genetics of Leptospira spp. This study will also contribute to a better knowledge of phages unrelated to lambdoid phages.
Incorporating Insulin Growth Factor-1 into Regenerative and PersonalizedMedicine for Cardiovascular Disease: A Systematic Review (2022)

Incorporating IGF-1 into regenerative and personalized medicine may be promising for treating CVD; however, the concerns include the role of IGF-1 in inducing cancer growth and its ability to migrate to the specific site of injury, especially for those who present with multiple pathologies should be addressed prior to its translation from bench work into clinical settings.
A Wide-Band Low-Noise Amplifier with Double Loop Feedback (2005)

There is increasing interest in wireless receivers that can work with different standards at different frequencies. The usual way of implementing a low noise amplifier (LNA) block in such a receiver is to use separate narrowband LNAs. In this paper, a wideband LNA is presented, with negative feedback by means of a double loop feedback network to achieve simultaneously a low noise figure and input matched impedance for a wide range of frequencies. The designed LNA has a noise figure lower than 3 dB, input impedance matched to 50 /spl Omega/ and a gain above 12 dB for a frequency range between 700 MHz; and 5 GHz. The LNA has been designed in 0.18 /spl mu/m CMOS technology from National Semiconductor. It consumes 18.9 mW for a supply voltage of 1.8 V.
Real-Time Thermomechanical Modeling of PV Cell Fabrication via a POD-Trained RBF Interpolation Network (2020)

This paper presents a numerical reduced order model framework to simulate the physics of the thermomechanical processes that occur during c-Si photovoltaic (PV) cell fabrication. A response surface based on a radial basis... | Find, read and cite all the research you need on Tech Science Press
Quantifying the potential of ultra-permeable membranes for water desalination (2014)

In the face of growing water scarcity, it is critical to understand the potential of saltwater desalination as a long-term water supply option. Recent studies have highlighted the promise of new membrane materials that could desalinate water while exhibiting far greater permeability than conventional reverse osmosis (RO) membranes, but the question remains whether higher permeability can translate into significant reductions in the cost of desalinating water. Here, we address a critical question by evaluating the potential of such ultra-permeable membranes (UPMs) to improve the performance and cost of RO. By modeling the mass transport inside RO pressure vessels, we quantify how much a tripling in the water permeability of a membrane would reduce the energy consumption or the number of required pressure vessels for a given RO plant. We find that a tripling in permeability would allow for 44% fewer pressure vessels or 15% less energy for a seawater RO plant with a given capacity and recovery ratio. Moreover, a tripling in permeability would result in 63% fewer pressure vessels or 46% less energy for brackish water RO. However, we also find that the energy savings of UPMs exhibit a law of diminishing returns due to thermodynamics and concentration polarization at the membrane surface.
Design and Evaluation of Human–Machine Interface for NEXUS: A Custom Microassembly System (2020)

Abstract Microassembly systems utilizing precision robotics have long been used for realizing three-dimensional microstructures such as microsystems and microrobots. Prior to assembly, microscale components are fabricated using micro-electromechanical-system (MEMS) technology. The microassembly system then directs a microgripper through a series of automated or human-controlled pick-and-place operations. In this paper, we describe a novel custom microassembly system, named NEXUS, that can be used to prototype MEMS microrobots. The NEXUS integrates multi-degrees-of-freedom (DOF) precision positioners, microscope computer vision, and microscale process tools such as a microgripper and vacuum tip. A semi-autonomous human–machine interface (HMI) was programmed to allow the operator to interact with the microassembly system. The NEXUS human–machine interface includes multiple functions, such as positioning, target detection, visual servoing, and inspection. The microassembly system's HMI was used by operators to assemble various three-dimensional microrobots such as the Solarpede, a novel light-powered stick-and-slip mobile microcrawler. Experimental results are reported in this paper to evaluate the system's semi-autonomous capabilities in terms of assembly rate and yield and compare them to purely teleoperated assembly performance. Results show that the semi-automated capabilities of the microassembly system's HMI offer a more consistent assembly rate of microrobot components and are less reliant on the operator's experience and skill.
E (1988)

This chapter contains sections titled: Economic Justification Economics, Robotic Manufacturing and Product Economics, Robot Market and Industry Education, Robotics Electric Power Industry, Robots in Electronics Industry, Robots in Employment, Impact End-of-Arm Tooling Ergonomics Ergonomics, Human–Robot Interface Egronomics, Robot Selection Ergonomics, Workplace Design Expert Systems
Inhibition of HIV Type 1 Replication in CD4 + and CD14 + Cells Purified from HIV Type 1-Infected Individuals by the 2-5A Agonist Immunomodulator, 2-5A N6B (2007)

Two major interferon (IFN)-mediated antiviral defense enzymes are double-stranded (ds)RNA-dependent 2',5'-oligoadenylate (2-5A) synthetase (2-5OAS) and p68 kinase (PKR). When activated by dsRNA, 2-5OAS synthesizes 2-5A, which binds to and activates RNase L. Activated RNase L hydrolyzes single-stranded viral RNA, thereby inhibiting viral protein synthesis. HIV-1 inhibits the IFN-mediated intracellular antiviral pathways. We have reported the synthesis and characterization of a nuclease-resistant 2-5A agonist (2-5A(N6B)) that overcomes the HIV-1 induced blockades by restoring the 2-5OAS/RNase L antiviral pathway (Homan JW, et al., J Acquir Immune Defic Syndr 2002;30:9-20). The objective of this study was to test the effect of 2-5A(N6B) on chronically infected CD4(+) T lymphocytes and CD14(+) monocytes derived from HIV-1-seropositive individuals. Wild-type HIV-1 replication was effectively inhibited by 2-5A(N6B) in CD4(+) T lymphocytes and CD14(+) monocytes purified from HIV-1 seropositive individuals (n = 18) compared to untreated cells. We also assessed the cytotoxicity of 2-5A(N6B) and report that 2-5A(N6B) exerts its anti-HIV-1 activity with no evidence of cytotoxicity (IC(90) > 100,000 nM). Furthermore, 2-5A(N6B) did not alter the cellular RNA profile, affect CCR5 or CXCR4 coreceptor expression, or activate caspase-dependent apoptosis. Evidence is also provided to show that 2-5A(N6B), and naturally occurring 2-5A(4), act as ligands to activate human Toll-like receptor 4. These results indicate that the 2-5A agonist 2-5A(N6B) has the potential to enhance host cell innate and acquired immune defense mechanisms against HIV-1 infection.
Fludarabine Nucleoside Modulates Nuclear “Survival and Death” Proteins in Resistant Chronic Lymphocytic Leukemia Cells (2011)

The nuclear mechanisms by which fludarabine nucleoside (F-ara-A) induces apoptosis have been investigated in human MEC1 cells derived from B-cell chronic lymphocytic leukemia. Upon treatment of cells with F-ara-A (100 μM, 72 hours), 15 nuclear proteins changed in abundance by more than 2-fold. Nuclear proteins up-regulated included calmodulin (4.3-fold), prohibitin (3.9-fold), β-actin variant (3.7-fold), and structure-specific recognition protein 1 (3.7-fold); those down-regulated included 60S ribosomal protein P2B (0.12-fold), fumarate hydratase (0.19-fold), splicing factor arginine/serine-rich 3 (0.35-fold), and replication protein A2 (0.42-fold). These changes in the levels of specific proteins promote survival or apoptosis; because the end result is apoptosis of MEC1 cells, apoptotic effects predominate.
Eukaryotic DNA topoisomerase I: genome gatekeeper and its intruders, camptothecins. (1996)

Topoisomerase I enzymes are ubiquitous and play a pivotal role in DNA transcription, replication, and repair. The eukaryotic form of this enzyme is highly conserved and its inhibition leads to accumulation of DNA strand breaks ('cleavable complexes') and ultimately cell death. An understanding of the role of eukaryotic topoisomerase I has led researchers to identify this enzyme as a potential target for anticancer therapy. Indeed, topoisomerase I is inhibited by samptothecin (isolated from a plant extract), and derivatives of this agent are being developed with improved physicochemical and pharmacologic characteristics. These agents may provide a new dimension to chemotherapy through their novel mechanism of action.
The mechanical properties of SiC whisker reinforced Al2O3 composite. (1989)

Al2O3 composites reinforced with (0-40)mass% SiC whisker were prepared at a temperature range 1673 K-2123 K for 3.6 ks under 40 MPa by hot-pressing and the effects of pretreatment process of SiC whisker and SiC whisker content on the mechanical properties of the composites were mainly investigated. The toughening mechanism of Al2O3 by addition of SiC whisker was also discussed.The results obtained were summarized as follows: The bending strength of the Al2O3-30 mass% SiC whisker composites with SiC whisker pretreated by ultrasonic disperser and filtration was remarkably improved comparing with that of the composites with untreated SiC whisker, then it showing about 1 GPa. The desification temperature to get full density of each composite increased with SiC whisker content. The SiC whisker in the composites was preferentially aligned in normal direction to the hot-pressing axis and the directional dependence of the mechanical properties was observed. The mechanical properties at room temperature and the failure resistance of the composites with pretreated SiC whisker increased with SiC whisker content. The toughening mechanism of Al2O3 by the addition of SiC whisker was considered to be due to the increase of fracture energy generating suppression against crack growth and crack deflection.
Wake Vortex Effects due to Horizontal Crossing at Any Angle (2022)

The effects of wake crossing at any horizontal angle, airspeed, and altitude are considered, focusing on crossing at cruise speeds at altitudes close to the tropopause. The roll effect is considered in two cases: 1) specification of the aileron deflection as a function of time that exactly compensates for the rolling moment induced on the crossing aircraft by the wake of the leading aircraft so that the crossing aircraft is undisturbed; and 2) in the case when the available roll control power is not sufficient to compensate completely for the wake induced rolling moment, the resulting roll rate and bank angle of the crossing aircraft are calculated as a function of time. The distinction between the two cases is made by a safe separating distance or safe separating time: beyond which, roll compensation 1) is possible; and below which, rolling motion 2) is unavoidable. Besides the roll acceleration, roll rate, and bank angle for the roll axis, the effects of wake crossing are also considered for the vertical axis, including the load factor, vertical velocity, and altitude change. The theory applies to any pair of aircraft and indicates the dependence on aircraft parameters, flight, and atmospheric conditions.
Five-year survey of ochratoxin A in processed sultanas from Turkey (2007)

The results of surveillance for ochratoxin A (OTA) in 1885 samples of sultanas taken during five crop years between 1999 and 2003 are reported. The analytical method was based on extraction with methanol + sodium bicarbonate and clean-up by immunoaffinity column chromatography followed by high-performance liquid chromatography with fluorescence detection. The limit of detection for OTA was 0.3 microg kg(-1). The results show that 9.3% of the samples contained no detectable levels of OTA, whereas 0.6% had concentrations exceeding 10 microg kg(-1); the remaining 90.3% had levels within the range 0.3-10 microg kg(-1). The overall mean OTA concentration in the total number of 1885 samples taken was 1.36 +/- 2.91 microg kg(-1); the overall median was calculated as 0.90 microg kg(-1).
Resonances and circuit theory for the interaction of metallic disks and annuli with an electromagnetic field (2014)

To understand the nature of the electromagnetic resonances of finite metallic surfaces, we formulate a rigorous and rapidly convergent circuit theory for the interaction of a metallic disk and a metallic annulus with an electromagnetic field. Expressions for the current induced and the resonance condition are derived. A new understanding of the nature of the resonances is obtained. For half of the resonances we find a divergent electric field at the edge of the disk, even though it is smooth in shape. For the disk, we compare with previous results using vector spheroidal wave functions and found good agreement for the resonance condition. Our approach can be generalized to other finite surfaces.
Physical hierarchy generation with routing congestion control (2002)

In this paper, we develop a multi-level physical hierarchy generation (mPG) algorithm integrated with fast incremental global routing for directly updating and optimizing congestion cost during placement. The fast global routing is achieved by using a fast two-bend routing and incremental A-tree algorithm. The routing congestion is modeled by the wire usage estimated by the fast global router. A hierarchical area density control is also developed for placing objects with significant size variations. Experimental results show that, compared to Gordian-L, the wire length driven mPG is 3-6.5 times faster and generates slightly better wire length for test circuits larger than 100K cells. Moreover, the congestion driven mPG improves 50% wiring overflow with 5% larger bounding box wire length but 3-6% shorter routing wire length measured by graph based A-tree.
Deep Reinforcement Learning that Matters (2017)

In recent years, significant progress has been made in solving challenging problems across various domains using deep reinforcement learning (RL). Reproducing existing work and accurately judging the improvements offered by novel methods is vital to sustaining this progress. Unfortunately, reproducing results for state-of-the-art deep RL methods is seldom straightforward. In particular, non-determinism in standard benchmark environments, combined with variance intrinsic to the methods, can make reported results tough to interpret. Without significance metrics and tighter standardization of experimental reporting, it is difficult to determine whether improvements over the prior state-of-the-art are meaningful. In this paper, we investigate challenges posed by reproducibility, proper experimental techniques, and reporting procedures. We illustrate the variability in reported metrics and results when comparing against common baselines and suggest guidelines to make future results in deep RL more reproducible. We aim to spur discussion about how to ensure continued progress in the field by minimizing wasted effort stemming from results that are non-reproducible and easily misinterpreted.
DFM lessons learned from altPSM design (2008)

The design challenges associated with alternating phase shifted mask lithography are discussed, solutions which had been developed to address these challenges are reviewed, and parallels to current design for manufacturability implementation issues are identified. Leveraging these insights, the positive attributes of a well integrated design for manufacturability enhanced design flow are proposed. Specific topics covered in the paper are: the need to complement error-detection with streamlined layout-correction, the risk of providing too much unstable information too early in the design optimization flow, the efficiencies of prescriptive 'correct-by-construction' solutions, and the need for seamless integration into existing design flows. For the benefit of the non-lithographer, the discussion of these detailed topics is preceded by a brief review of alternating phase shifted mask lithography principles and benefits.
A Novel Role for Snapin in Dendrite Patterning: Interaction with Cypin (2005)

Temporal and spatial assembly of signal transduction machinery determines dendrite branch patterning, a process crucial for proper synaptic transmission. Our laboratory previously cloned and characterized cypin, a protein that decreases PSD-95 family member localization and regulates dendrite number. Cypin contains zinc binding, collapsin response mediator protein (CRMP) homology, and PSD-95, Discs large, zona occludens-1 binding domains. Both the zinc binding and CRMP homology domains are needed for dendrite patterning. In addition, cypin binds tubulin via its CRMP homology domain to promote microtubule assembly. Using a yeast two-hybrid screen of a rat brain cDNA library with cypin lacking the carboxyl terminal eight amino acids as bait, we identified snapin as a cypin binding partner. Here, we show by affinity chromatography and coimmunoprecipitation that the carboxyl-terminal coiled-coil domain (H2) of snapin is required for cypin binding. In addition, snapin binds to cypin's CRMP homology domain, which is where tubulin binds. We also show that snapin competes with tubulin for binding to cypin, resulting in decreased microtubule assembly. Subsequently, overexpression of snapin in primary cultures of hippocampal neurons results in decreased primary dendrites present on these neurons and increased probability of branching. Together, our data suggest that snapin regulates dendrite number in developing neurons by modulating cypin-promoted microtubule assembly.
Treatment of folliculitis decalvans by photodynamic therapy using a new light-emitting device: A case series of 4 patients (2021)

Folliculitis decalvans (FD) is a rare condition that affects young people, with a slight predominance in males. The lesions start with follicular erythema that progresses to pustules. The pustules evolve into a crust, leading to hair loss and scarring alopecia. The etiology of FD is unknown but could involve an inadequate immune response to Staphylococcus aureus, resulting in a chronic inflammatory reaction of the affected area. Treatment of FD can be challenging. The aim of the treatment is to stop the development of pustules and the extension of irreversible alopecia.
Supplementary methods from Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer (2023)

&lt;p&gt;This file contains supplementary methods&lt;/p&gt;
Reliability Techniques for RFID-Based Object Tracking Applications (2007)

Radio Frequency Identification (RFID) technology has the potential to dramatically improve numerous industrial practices. However, it still faces many challenges, including security and reliability, which may limit its use in many application scenarios. While security has received considerable attention, reliability has escaped much of the research scrutiny. In this work, we investigate the reliability challenges in RFID-based tracking applications, where objects (e.g., pallets, packages, and people) tagged with low-cost passive RFID tags pass by the RFID reader's read zone. Our experiments show that the reliability of tag identification is affected by several factors, including the inter-tag distance, the distance between the tag and antenna, the orientation of the tag with respect to the antenna, and the location of the tag on the object. We demonstrate that RFID system reliability can be significantly improved with the application of simple redundancy techniques.
Hybrid Large-Eddy Simulation / Reynolds-Averaged Navier-Stokes Simulations of Sonic Injection into Mach 2 Crossflow (2011)

This paper presents numerical simulations of sonic injection of ethylene into a Mach 2 crossflow of air. Experimental Raman scattering imagery, pressure-sensitive paint data and NO-PLIF images are compared with hybrid LES/RANS simulations. The impact of a low-diusion method on the hybrid LES/RANS solutions is investigated. The eect of grid coarsening is also investigated. The low-dissipation approximation (LD-PPM) is shown to be less impacted by the grid coarsening, but it is numerically unstable at high injection pressures. A three-dimensional visualization of velocity tensor discriminant is used to show the dierences between the vortical structures of PPM and LD-PPM as well as the impact of grid coarsening on these structures. The implications of these findings on future research is also presented.