gebhart/patrepeval huggingface dataset:
Avaliação in vitro de um novo filtro de veia cava (2005)

OBJETIVO: O objetivo do estudo foi avaliar a eficácia de um novo filtro de veia cava, de baixo perfil, na retenção de coágulos em modelo in vitro. MÉTODO: O filtro consiste em dois cones opostos pelo ápice. O cone distal é formado por oito hastes de aço inoxidável, que têm a função de retenção dos êmbolos. O cone proximal é constituído de quatro hastes, cuja função é ancorar e centralizar. Os filtros foram introduzidos e fixados no interior de um tubo de PVC transparente de 25, 30 e 35 mm de diâmetro interno, em posição vertical, e conectados com um sistema pulsátil de fluxo (bomba peristáltica). Foi utilizado, para veículo, um reservatório com solução salina (0,9%) com 40% de glicerina, mantido em temperatura ambiente. Confeccionaram-se trombos com sangue bovino em tubos plásticos de 3, 4,5 e 6 mm de diâmetro e, posteriormente, foram segmentados nas medidas de 10, 15, 20 e 30 mm de comprimento, totalizando 12 diferentes tamanhos. Realizaram-se 100 liberações para cada tipo de êmbolo e tamanho das cânulas, totalizando 3.600 eventos. Foram feitos lançamentos seqüenciais com cinco êmbolos, sendo 10 para cada tamanho de êmbolo e cânulas, totalizando 360 eventos. Fez-se avaliação da capacidade de retenção dinâmica utilizando os três diferentes tamanhos de cânulas com 100 eventos cada, totalizando 300 eventos. RESULTADOS: Detectou-se que o diâmetro e comprimento dos êmbolos, assim como diâmetros da cânula, podem comprometer a eficácia do filtro. A média de captura de êmbolos pelos filtros foi de 80,5% nas cânulas de 35 mm, 88,7% para cânulas de 30 mm e 86,6% para cânulas de 25 mm. CONCLUSÃO: Conclui-se que a eficácia desse filtro sofre interferência relacionada ao tamanho dos êmbolos e diâmetro da cânula.
Automated System for Semantic Object Labeling With Soft-Object Recognition and Dynamic Programming Segmentation (2016)

This paper presents an automated robotic system for generating semantic maps of inventory in retail environments. In retail settings, semantic maps are labeled maps of stores where each discrete section of shelving is assigned a department label describing the types of products on that shelf. Starting from a metric map of the store, the robot autonomously extracts the shelf boundaries, generates a distance-optimal tour of the store to view every shelf, and follows the tour while avoiding unmapped clutter and moving people. The robot creates a point cloud of the store using the data collected from this tour. We introduce a novel soft-object assignment algorithm to create a virtual map and a dynamic programming algorithm to segment this map. These algorithms use a priori information about the products to boost data from laser and camera sensors in order to recognize and semantically label objects. The primary contribution of this paper is the integration of multiple systems for automated path planning, navigation, object recognition, and semantic mapping. This paper represents an important contribution toward deploying mobile robots in dynamic human environments.
Learning to predict problematic situations in a spoken dialogue system: experiments with how may I help you? (2000)

Current spoken dialogue systems are deficient in their strategies for preventing, identifying and repairing problems that arise in the conversation. This paper reports results on learning to automatically identify and predict problematic human-computer dialogues in a corpus of 4774 dialogues collected with the How May I Help You spoken dialogue system. Our expectation is that the ability to predict problematic dialogues will allow the system&amp;apos;s dialogue manager to modify its behavior to repair problems, and even perhaps, to prevent them. We train a problematic dialogue classifier using automaticallyobtainable features that can identify problematic dialogues significantly better (23%) than the baseline. A classifier trained with only automatic features from the first exchange in the dialogue can predict problematic dialogues 7% more accurately than the baseline, and one trained with automatic features from the first two exchanges can perform 14% better than the baseline. 1 Introduction ...
Plasma Testosterone and Prognosis of Postmenopausal Breast Cancer Patients (2007)

High plasma testosterone strongly predicts poorer prognosis in postmenopausal BC patients not administered adjuvant therapy. Testosterone levels should be determined as part of the prognostic work-up.
Electroluminescence from sulfur impurities in a p-n junction formed in epitaxial silicon (1989)

We characterize the behavior of electroluminescence from a sulfur-related impurity complex in a p-n junction formed in epitaxial silicon. The spectrum of the electroluminescence matches that of previously reported photoluminescence from sulfur impurities and persists to ∼150 K. In our structure, we find that the electroluminescence exhibits an external quantum efficiency of 0.2–0.5%.
Gait Analysis of Unilateral Transfemoral Amputees with Prosthetics on an Inclined Surface (2006)

Objective: The aim of this study was to investigate the characteristics of prosthetic gait of unilateral transfemoral amputees on an inclined surface compared with those of normal persons. Method: Five male unilateral transfemoral amputees and ten normal persons were recruited. Uphill and downhill walking of inclined surface on slopes of 10 and 20 degrees and level walking were investigated. Kinematic data were obtained with VICON 370 system (Oxford Metrics Ltd., UK). Results: The kinematic data of the transfemoral amputees showed significantly decreased peak hip extension at all situation and peak hip flexion at 20 degrees uphill walking, significant increased knee extension at 20 degrees downhill and all uphill walking, and significant decreased knee flexion at all situation, and significant decreased ankle dorsiflexion at all situation and plantarflexion at all situation except 20 degrees downhill walking compared with those of normal persons. Also they showed significant decreased cadence, speed and increased step time, double support at all situation compared with normal persons. Conclusion: Analysis of prosthetic gait of unilateral transfemoral amputees on an inclined surface support the basic data for induction of normal gait pattern. (J Korean Acad Rehab Med 2006; 30: 69-73)
1P1-M04 Development of occlusal sound listening system with suction cup(Medical Robotics and Mechatronics (1)) (2012)

For healthy chewing, normal occlusion without local overload is necessary. However, the current occlusal examination depends on techniques, skills, and sense of doctors. Therefore it is an important issue to establish an equipment that can check occlusal condition easily, accurately and objectively. This research aims to realize novel checking system listening to occlusal sound using microphone. In this research, establishment of methodology realizing connection between a device having a microphone and teeth is breakthrough. In order to attach the device on teeth, we have developed a soft suction cup applied negative pressure. We have conducted experiments of detecting occlusal sound using this device in the oral cavity.
A Multi-body Integrated Vehicle-Occupant Model for Compatibility Studies in Frontal Crashes (1999)

Abstract Vehicle acceleration and passenger compartment intrusion primarily determine car occupant injury risk. A new integrated vehicle-occupant model was developed and validated to predict these vehicle responses in offset, concentrated or full-width impact with various objects. The multi-body mathematical model consisted of a compartment, dash-panel and toepan-area and a front structure. The front structure was subdivided in 12 segments and a power-train, which were connected to the firewall by kinematic joints. The joints used local stiffness obtained from load-cell barrier crash-tests, and enabled local deformation of the vehicle front Similarly, the dash-panel and toepan were connected to the compartment, which enabled local intrusion into the compartment. A vehicle interior was modeled to enable contact-interactions with occupants, and the firewall geometry was included for interactions with the power-train. The vehicle-model was validated with full frontal and 50% offset data and predicted vehicle acceleration, crush profile and local intrusion well. The validity of the model indicates its applicability in a wide range of frontal (non-distributed) collisions. Due to the use of local stiffness data, the model can greatly improve accident reconstruction research especially in frontal offset and pole impacts at both high and low speeds. The vehicle-model can be easily adjusted by changing vehicle-mass, size, or local stiffnesses of the front structure, and is a useful tool in compatibility research to estimate trends in car crash compatibility. Keywords: Frontal crashintegrated vehicle-occupant modeloccupant injurycompartment intrusioncrash compatibility
Status of vaccine research and development of vaccines for HIV-1 (2016)

Human immunodeficiency virus (HIV) is the cause of one of the most lethal pandemics in human history, although in recent years access to highly effective anti-retroviral therapy has provided new hope worldwide. Transmission of HIV by sexual contact, childbirth and injection drug use has been reduced, but 2 million are newly infected each year, and much of the transmission is from people who do not know their status. In addition to known methods, a preventive vaccine is needed to end the pandemic. The extraordinary mutability and genetic diversity of HIV is an enormous challenge, but vaccines are being designed for broad coverage. Computer-aided design of mosaic immunogens, incorporating many epitopes from the entire genome or from conserved regions aim to induce CD8+ T cells to kill virus-infected cells or inhibit virus replication, while trimeric envelope proteins or synthetic mimics aim to induce broadly reactive neutralizing antibodies similar to those cloned from some infected patients. Induction of more potent and durable responses may require new adjuvants or replicating chimeric vectors chimeras that bear HIV genes. Passive or genetic delivery of broadly neutralizing antibodies may provide broad protection and/or lead to insights for vaccine designers. Proof-of-concept trials in non-human primates and in one human efficacy trial have provided scientific clues for a vaccine that could provide broad and durable protection against HIV. The use of vaccines to destroy HIV reservoirs as part of therapy or cure is now also being explored.
Heating Methods for Deployment of CHEM Foam Structures (2003)

&lt;div class="htmlview paragraph"&gt;In this paper, the advantages and disadvantages of many methods for deployment of CHEM foam structures are discussed. The best heating method is determined to be the use passive solar heating via a thermal blanket due to its simplicity, minimal payload and spacecraft requirements, and cost. An initial theoretical model of this heating method is presented and explored for a thermal blanket with an absorptance to emittance ratio of 15. The model found this heating method to be feasible for deploying up to 10 cm thick structures on the Mars surface and up to 15 cm thick structures in a solar orbit at a solar distance of 1 AU.&lt;/div&gt;
The regulation of proresolving lipid mediator profiles in adipose tissue of rats with diet-induced prediabetes (2019)

17th Euro Fed Lipid Congress: Oils, Fats and lipids: Driving Science and Technology to New Horizons, 20-23 October 2019, Seville
Metabolomics analysis of muscle from piglets fed low protein diets supplemented with branched chain amino acids using HPLC‐high‐resolution MS (2015)

Low protein (LP) diet can reduce feed costs and decrease nitrogen emission. Branched chain amino acids (BCAA), especially leucine, have been shown to influence muscle protein metabolism. Here, we used HPLC-high-resolution MS-based metabolomics approach to investigate the effects of LP diet supplemented with BCAA on metabolome in the muscle of piglets. The 10-21 kg piglets were fed with LP diet supplemented with BCAA. Amino acids (AAs) and metabolomics profiles of plasma, muscle, and liver were analyzed. Free AA profiles of plasma showed increased levels of BCAA. Multivariate analysis showed significant difference in skeletal muscle metabolites among different diet treatment groups, and most of the identified differential compounds were involved in AA metabolism and protein anabolism. These compounds, including alanine, glutamine, sarcosine, ornithine, proline, methionine, and threonine, all increased in the BCAA supplemented group compared with normal protein diet group. Metabolic pathway analysis suggested that BCAA could be converted to nonessential AAs and their metabolites by direct or indirect synthesis under LP diets, which could participate in the muscle protein synthesis or energy metabolism, and ultimately reduced nitrogen emission.
Platelet Aggregation and Activation under Complex Patterns of Shear Stress (2002)

Arterial stenosis results in a complex pattern of blood flow containing an extremely fast flow in the throat of stenosis and a post-stenosis low flow. The fast flow generates high shear stress that has been demonstrated in vitro to activate and aggregate platelets. One potential problem of these in vitro studies is that platelets are invariably exposed to a high shear stress for a period that is significantly longer than they would have experienced in vivo. More importantly, the role of the post-stenosis low flow in platelet activation and aggregation has not been determined. By exposing platelets to a shear profile that contains both high and low shear segments, we found that platelets aggregate when they are exposed to a high shear stress of 100 dyn/cm(2) for as short as 2.5 s, a period that is significantly shorter than those previously reported (30-120 s). Platelet aggregation under this condition requires a low shear exposure immediately after a high shear pulse, suggesting that post-stenosis low flow enhances platelet aggregation. Furthermore, platelet aggregation under this condition is not activation-dependent because the CD62P expression of sheared platelets is significantly less than that of platelets treated with ADP. Based on these findings, we propose that shear-induced platelet aggregation may be a process of mechanical crosslinking of platelets, requiring minimal platelet activation. This process may function as a protective mechanism to prevent in vivo irreversible platelet activation and aggregation under temporary high shear.
Supplementary Figures 1 through 3 and Supplementary Tables 1 through 3 from Analyses of Pretherapy Peripheral Immunoscore and Response to Vaccine Therapy (2023)

&lt;p&gt;Supplementary Figure S1: Gating strategy to identify classic peripheral immune cell types and refined immune cell subsets with phenotypes reflecting immune function that were used to generate the peripheral immunoscores of patients treated with docetaxel plus or minus PANVAC. Supplementary Figure S2: Gating strategy to identify classic peripheral immune cell types and refined immune cell subsets with phenotypes reflecting immune function that were used to generate the peripheral immunoscores of patients treated with Quadramet plus or minus PROSTVAC. Supplementary Figure S3: Point assignment method used in generating peripheral immunoscores. Supplementary Table S1: Antibodies and panels used in flow cytometry analysis to identify immune cells. Supplementary Table S2: PBMC frequencies (min, median, max) and bin cutoffs used in generating peripheral immunoscores in breast cancer patients treated with docetaxel +/- PANVAC vaccine and prostate cancer patients treated with Sm-153 (Quadramet) +/- PROSTVAC vaccine. Supplementary Table S3: Summation of points assigned to individual subsets to generate peripheral immunoscore.&lt;/p&gt;
Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease (2018)

Autosomal dominant polycystic kidney disease (ADPKD) is a widespread genetic disease that leads to renal failure in the majority of patients. The very first pharmacological treatment, tolvaptan, received Food and Drug Administration approval in 2018 after previous approval in Europe and other countries. However, tolvaptan is moderately effective and may negatively impact a patient's quality of life due to potentially significant side effects. Additional and improved therapies are still urgently needed, and several clinical trials are underway, which are discussed in the companion paper Müller and Benzing (Management of autosomal-dominant polycystic kidney disease-state-of-the-art) <i>Clin Kidney J</i> 2018; <b>11</b>: i2-i13. Here, we discuss new therapeutic avenues that are currently being investigated at the preclinical stage. We focus on mammalian target of rapamycin and dual kinase inhibitors, compounds that target inflammation and histone deacetylases, RNA-targeted therapeutic strategies, glucosylceramide synthase inhibitors, compounds that affect the metabolism of renal cysts and dietary restriction. We discuss tissue targeting to renal cysts of small molecules via the folate receptor, and of monoclonal antibodies via the polymeric immunoglobulin receptor. A general problem with potential pharmacological approaches is that the many molecular targets that have been implicated in ADPKD are all widely expressed and carry out important functions in many organs and tissues. Because ADPKD is a slowly progressing, chronic disease, it is likely that any therapy will have to continue over years and decades. Therefore, systemically distributed drugs are likely to lead to potentially prohibitive extra-renal side effects during extended treatment. Tissue targeting to renal cysts of such drugs is one potential way around this problem. The use of dietary, instead of pharmacological, interventions is another.
Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced byl-NAME treatment in pregnant rats (2005)

We previously reported that inhibition of nitric oxide (NO) synthesis by N-nitro-L-arginine methyl ester (L-NAME) during late pregnancy leads to increased production of renal vascular 20-hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P-450 (CYP) 4A-derived vasoconstrictor, in pregnant rats. However, the effect of upregulation of vascular 20-HETE production on renal function after NO inhibition is not known. To test the hypothesis that increased gestational vascular 20-HETE synthesis after NO inhibition is involved in mediating blood pressure and renal functional changes, we first determined the IC(50) value of the effect of nitroprusside (SNP), a NO donor, on renal 20-HETE production in cortical microsomes. We then divided pregnant rats and age-matched virgin rats into a vehicle control group, an L-NAME treatment group (0.25 mg/ml in drinking water), and a group treated with L-NAME plus N-methylsulfonyl-12,12-dibromododec-11-enamide (DDMS; CYP4A-selective inhibitor, 10 mg.kg(-1).day(-1) iv). After 4 days of treatment, we measured blood pressure, renal blood flow (RBF), renal vascular resistance (RVR), and glomerular filtration rate (GFR) in each group. The addition of SNP (IC(50) = 22 microM) decreased renal cortical 20-HETE production. In pregnant rats, L-NAME treatment led to significantly higher mean arterial pressure (MAP) and RVR, and lower RBF and GFR. Combined treatment with DDMS and L-NAME significantly attenuated the increases in MAP and RVR and the decrease in GFR, but not the reduction in RBF induced by L-NAME treatment. L-NAME and L-NAME plus DDMS had no significant impact on renal hemodynamics in virgin rats. In addition, chronic treatment with DDMS selectively inhibited cortical 20-HETE production without a significant effect on CYP4A expression in L-NAME-treated pregnant rats. In conclusion, NO effectively inhibits renal cortical microsomal 20-HETE production in female rats. In pregnant rats, the augmentation of renal 20-HETE production after NO inhibition is associated with increased MAP and RVR, whereas decreased GFR is negated by treatment of a selective and competitive CYP4A inhibitor. These results demonstrate that the interaction between renal 20-HETE and NO is important in the regulation of renal function and blood pressure in pregnant rats.
Impact Of Splenomegaly On Mpn Symptoms And Association With Clinical Features : An Analysis By The Mpn Quality Of Life International Study Group (2016)

Impact Of Splenomegaly On Mpn Symptoms And Association With Clinical Features : An Analysis By The Mpn Quality Of Life International Study Group
PI3Kγ Protects from Myocardial Ischemia and Reperfusion Injury through a Kinase-Independent Pathway (2010)

Our data show that PI3Kgamma is cardioprotective during M I/R injury independent of its catalytic kinase activity and that loss of PI3Kgamma function in the hematopoietic compartment does not affect disease outcome. Thus, clinical development of specific PI3Kgamma blockers should proceed with caution.
Structural and functional interactions between measles virus nucleocapsid protein and cellular heat shock protein (2004)

Cells respond to stress by producing heat shock proteins (HSPs), particularly the major inducible 72kDa protein (Hsp72).Although HSPs are generally viewed as protecting cells against injury, data has also shown that elevated cellular Hsp72 promotes damage induced by measles virus (MV) in vitro.Specifically, Hsp72 enhances MV transcription and replication activity, resulting in increased viral antigen expression, cytopathic effect, and infectious viral progeny release.Hsp72-dependent stimulation of MV transcription reflects functional interactions between Hsp72 and an 8 amino acid (aa) binding motif within the extreme C-terminus of the nucleocapsid protein (N), a major structural component of the nucleocapsid.Nucleocapsid consists of viral genomic RNA packaged by N, polymerase cofactor (P), and the viral encoded RNA-dependent RNA polymerase (L).The nucleocapsid activity can be measured using minireplicons in which the viral genomic coding sequence is replaced by chloramphenical acetyltransferase (CAT) RNA.Using this approach, we identified the C-terminal 24 amino acids of N protein as a negative regulatory domain of MV transcription.Addition of Hsp72 by transfection significantly stimulates viral transcription/replication activity mediated by N. Mutations in the Hsp72 binding motif based upon naturally occurring sequence polymorphisms can diminish Hsp72 stimulation of MV minireplicon reporter gene expression.Loss of functional interactioniii correlates to the loss of low affinity binding interaction.Binding interactions were monitored in real time using surface plasmon resonance technology (BIAcore).These same mutations, when incorporated into the N protein of recombinant infectious virus, also abrogate Hsp72-dependent infection phenotypes.Incorporation of a non-functional Hsp72 binding motif reduced the stimulatory effect of pre-conditioning upon viral transcription, cytopathic effect (CPE), and cell-free infectious viral progeny release.However, loss of a functional binding motif doesn't abrogate the stimulatory effect of pre-conditioning on viral genome levels.N protein lacking the Hsp72 binding motif maintains the ability to form a stable complex with Hsp72 by both nucleocapsid-Hsp72 particle isolation as well as N-Hsp72 co-immunoprecipitation.BIAcore analysis of the last 125 aa of N protein (Ntail) and Hsp72 interaction confirmed the existence of additional Hsp72 binding domains.The relevance of high affinity interactions to Hsp72dependent stimulation of MV genome replication remains to be established.