gebhart/patrepeval huggingface dataset:
Dry Skin And Moisturizers: Chemistry And Function (2000)

Part 1: Dry Skin and Moisturizers Introduction - Albert Kligman Part 2: Biochemistry and Function of the Skin Epidermal Composition - Donald T. Downing and Mary Ellen Stewart The Skin as a Barrier - Magnus Lindberg and Bo Forslind Lipid and Protein Structures in the Permeability Barrier - Donald T. Downing and Noel D. Lazo The Environmental Interface: Regulation of Permeability Barrier Homeostasis - Kenneth R. Feingold and Peter M. Elias Permeability Barrier Homeostasis: The Role of Lipid Processing - Peter M. Elias, Walter M. Holleran, Cornelia J. Calhoun, Danielle Quiec, Barbara E. Brown, Martin Behne, and Kenneth R. Feingold Particle Probes and Skin Physiology - Bo Forslind and Jan Pallon The Distribution and Function of Physiological Elements in Skin - Ronald R. Warner Desquamation - Torbjoern Egelrud Part 3: Dry Skin and Hyperkeratotic Conditions Ichthyosis-An Inborn Dryness of the Skin - Anders Vahlquist Dry Skin in Atopic Dermatitis and Patients on Hemodialysis - Motoji Takahashi and Zenro Ikezawa Experimentally Induced Dry Skin - Mitsuhiro Denda Infantile Seborrheic Dermatitis - Donald Rudikoff Effects of Moisturizer and Keratolytical Agents in Psoriasis - Joachim W. Fluhr and Enzo Berardesca Part 4: Formulations and Interactions With The Skin Physico-Chemical Considerations - Eleanor J. Fendler Emulsifiers - Patricia A. Aikens and Stig E. Friberg Hydrophilic Pastes - Bernard Gabard and Christian Surber Glycerine: A Natural Ingredient for Moisturizing Skin - Donald S. Orth and Yohini Appa Effects of Natural Moisturizing Factor and Lactic Acid Isomers on Skin Function - Clive R. Harding, John Bartolone, and Anthony V. Rawlings Urea - Marie Loden Petrolatum - David S. Morrison Lanolins - Ian Harris and Udo Hoppe Skin Moisturizers: Development and Clinical Use of Ceramides - Genji Imokawa The Influence of Fatty Acids and Fatty Alcohols on Skin Permeability - Bruce J. Aungst Essential Fatty Acids - Lesley E. Rhodes Sphingolipids: From Chemistry to Possible Biologic Influence on the Skin - Hisashi Wakita Critical and Optimal Molar Ratios of Key Lipids - Carl Thornfeldt Effect of Moisturizing Products on the Structure of Lipids in the Outer Stratum Corneum of Humans - Ronald R. Warner and Ying Liu Boissy Part 5: Evaluation and Safety Study Design - David Salter Safety Assessment - Monica Tammela Human In Vivo Skin Irritancy Testing - Ebba Barany Non-Invasive Methods for Testing the Stratum Corneum Barrier - Ludger Kolbe Sensitizing Substances - Anton C. de Groot Glycols - Matti Hannuksela Contact Urticaria - Matti Hannuksela Sensitive Skin - Ai-Lean Chew and Howard I. Maibach Index
Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial (2021)

National Institute for Health Research, Cancer Research UK, and The Eve Appeal.
Functional Beads of Polyvinylpyrrolidone: Promising Support Materials for Solid‐Phase Synthesis (2006)

Abstract Summary: The solubility properties of polyvinylpyrrolidone (PVP) make it an attractive material for several different polymer‐assisted synthesis applications. However, PVP lacks reactive groups necessary for attaching compounds to the polymer. Furthermore, the radical reactivity of 1‐vinylpyrrolidin‐2‐one (NVP) is different from most other monomers, which results in compositional drift during copolymerization. Therefore, introducing reactive groups into the polymer using this method is intricate. Smaller differences in radical reactivity are expected from monomers that are derivatives of NVP itself. Hence, such monomers provide a way of preparing PVP with adjustable properties. Four new monomers containing pendant double bonds, all derivatives of NVP, were synthesized and used in the preparation of a new type of hydrophilic polymer bead by aqueous suspension polymerization. We also found that undec‐10‐en‐1‐ol can be used as a comonomer for the introduction of functional groups. The lightly crosslinked beads contain hydroxyl groups at a functional loading of 0.28 mmol/g and swell extensively in a broad range of solvents. Their potential as support materials has previously been demonstrated in a five‐step solid‐phase synthesis of 5‐(2,4,6‐trimethoxy‐phenyl)‐cyclohexa‐1,3‐dienecarboxylic acid. Scanning electron microscopy image of dry beads from PVP‐[B] 2 . magnified image Scanning electron microscopy image of dry beads from PVP‐[B] 2 .
Quantitative Formation of Monomeric G‐Quadruplex DNA from Multimeric Structures of c‐Myc Promoter Sequence (2020)

G-Quadruplex (G4)-forming DNA sequences have a tendency to form stable multimeric structures. This can be problematic for studies with synthetic oligodeoxynucleotides. Herein, we describe a method that quantitatively converts multimeric intermolecular structures of the Pu27 sequence from the c-myc promoter into the desired monomeric G4 by alkaline treatment and refolding.
P106 5-AMINOSALYCILIC ACID (5-ASA)-MEDIATED BLOCK OF COLON CANCER CELL GROWTH IS ASSOCIATED WITH DEGRADATION OF CDC25A AND ACCUMULATION OF CELLS IN S-PHASE (2007)

the follow up period were assessed. Out of the 490 patients,115 (23.5%) underwent intestinal resection at diagnosis of CD; the remaining 375 patients (76.5%), not operated at diagnosis, served as controls. Results: Patients with surgery at diagnosis of CD had lower need for steroids and immunomodulators during the follow up period compared to controls (OR 0.3,p<0.0001; OR 0.6, p<0.004,respectively). Time to first operation was longer in the patients with surgery at diagnosis compared to controls (10.8 years vs 5.8,p<0.01). The stricturing disease and the penetrating disease were found to be risk factors for surgery at diagnosis of CD (OR 19.7,p<0.0001; OR 20.0,p<0.0001, respectively). Conclusions: Surgery performed at diagnosis of CD was associated to a lower need for steroids and immunomodulators compared to controls. The time to first operation was longer in the patients with surgery at diagnosis compared to controls. These data suggest that in CD the early surgery could be more cost-effectiveness than long term medical therapies.
OPTIC FIBER NEEDLE ENDOSCOPE BASED RATIOMETER FOR TUMOR TARGETING (1998)

A optical fiber, needle-based, ratiometer for breast tumor targeting has been developed as an optical biopsy technique based on fluorescence spectroscopy. In vitro breast cancerous and normal tissues were measured using the ratiometer. Simulated experiments of detecting tumor in a breast were performed using a "sandwich" model made up of three tissue layers. Fluorescence measurement from these samples would be consistent with detection of cancerous tissue surrounded by normal breast tissue.
Apolipoprotein A-IMilano: current perspectives (2003)

Recombinant apolipoprotein A-I(Milano), formulated as synthetic HDL with phospholipids, appears to exert a direct removing effect on arterial cholesterol. This is well evident in experimental animals and, more recently in clinical findings, as indicated by a dramatic increase in HDL free cholesterol after the infusion of different doses of the agent. As the product appears to be well tolerated and non-immunogenic, ongoing phase II studies in patients are being awaited with interest to obtain a 'proof of principle' for 'HDL therapy'.
A phase I trial of lenalidomide maintenance after autologous stem cell transplant (ASCT) in patients with high-risk relapsed/refractory lymphomas. (2015)

8553 Background: Lymphoma patients (pts) with residual hypermetabolic lesions on PET imaging after salvage chemotherapy have extremely poor outcomes and may benefit from continued therapy after ASCT. Lenalidomide (len) has been used as maintenance in other hematologic malignancies, but its toxicity and efficacy are not well known in lymphoma pts following ASCT. Methods: We conducted a phase I trial of len maintenance after ASCT in lymphoma pts at high risk for relapse defined by residual PET positive lesions of SUV > 2.5 immediately prior to ASCT. Our primary objective was to determine the safety and dose-limiting toxicity (DLT) of len maintenance. A 3+3 de-escalation design was utilized with a starting dose of len at 10 mg on days 1 through 28 of each 28 day cycle (C). Len was initiated 28-100 days post-ASCT and planned for twenty four Cs. DLT was defined as non-hematologic toxicity ≥ grade (G)3 or hematologic toxicity ≥ G4 during the first 28 days of len. Enrollment began in 5/2012; reported data were collected through 1/2015. Results: Eight pts were enrolled and 6 pts are evaluable (4 diffuse large B-cell and 2 Hodgkin lymphomas). One pt withdrew consent and one progressed prior to initiation of len. Median age was 51 yrs (29-61), ECOG PS 0 (0- 1), prior therapies 3 (2-5). Median time on len was 7 Cs (2-24). Len was well tolerated and no DLT was observed at the 10 mg dose. Two pts required dose reduction to 5 mg due to treatment-related toxicities (after C7 and C3). Four pts had ≥ G2 non-hematologic adverse events possibly related to len including fatigue, bronchitis, and thrush. Three pts had transient ≥ G3 neutropenia. Two pts discontinued len (1 due to progression, 1 at investigator’s discretion). No secondary malignancies or study-related deaths were observed. Four of 6 pts remain on len and are progression free; 5 of 6 pts are alive with median follow-up of 195 days. Conclusions: We established safety of len after ASCT in pts with relapsed/refractory lymphomas and determined that len 10 mg daily is a well-tolerated maintenance dose in this setting. Preliminary clinical outcomes observed in this cohort of high-risk lymphoma pts are encouraging and will be validated in the ongoing phase II trial. Clinical trial information: NCT01575860.
LETHAL AND MUTAGENIC ACTION OF VACUUM‐AND FAR‐ULTRAVIOLET RADIATIONS ON DRY X174 PHAGE (1986)

Abstract Killing and mutation of dry X174 phages (amber mutant) were investigated with vacuum‐UV (130, 150 and 190 nm) and far‐UV (254 nm) radiations. The sensitivity to killing was greatest at 130 nm; the sensitivity (in terms of energy fluence) at 130 nm was about 17 times higher than that at 150 nm. The reversion frequency of amber mutants to pseudo‐wild type at 190 nm was lower than at 254 nm. Comparison of the induction rate of revertants per survivor showed that mutagenicity after 130 nm radiation, which may raise the ionization process, and after X‐rays was similar.
Sélection de modèles non linéaires par "leave-one-out": étude théorique et application des réseaux de neurones au procédé de soudage par points (1999)

Le soudage par points est la principale technique d'assemblage des tôles de carrosserie automobile. Cependant, la variabilité de ce procédé, et en particulier de l'état des électrodes de soudage, pose deux problèmes non résolus à ce jour: le contrôle non destructif de la qualité des soudures et la commande des paramètres de soudage. Utilisé fréquemment dans le domaine des réseaux de neurones, et réputé pour donner de bons résultats avec peu d'exemples, le leave-one-out conduit en réalité souvent à la sélection de modèles surajustés. Or, par un développement de Taylor, nous pouvons calculer l'effet du retrait d'un exemple de la base d'apprentissage sur la sortie du modèle. Nous prouvons que l'estimation de l'erreur de généralisation obtenue à partir de ce calcul est plus fiable que celle obtenue classiquement par apprentissage. Par ailleurs, nous montrons le lien existant entre le leave-one-out calculé et les intervalles de confiance sur la sortie du modèle. Enfin, nous proposons une technique originale de sélection de modèles non linéaires qui évite le surajustement en limitant l'influence de chaque exemple sur l'estimation des paramètres du modèle. Nous présentons une méthode permettant d'obtenir un modèle de prévision du diamètre d'une soudure, valable dans des conditions préétablies. Plus particulièrement, nous montrons comment constituer une base de données initiale, sélectionner le modèle adéquat, puis compléter progressivement la base d'apprentissage. Appliquée à deux types de tôles, cette méthode permet d'atteindre une précision proche de l'erreur de mesure. En outre, utilisés au sein d'une loi de commande, ces modèles permettent d'optimiser l'usure des électrodes.
Prognostic value of left ventricular volume response during dobutamine stress echocardiography (1997)

An abnormal end-diastolic volume response during dobutamine stress echocardiography identifies patients with an unfavourable outcome; they should be considered for more accurate prognostic stratification.
A Review of Principal Studies on the Development and Treatment of Epithelial Ovarian Cancer in the Laying Hen Gallus gallus (2021)

Often referred to as the silent killer, ovarian cancer is the most lethal gynecologic malignancy. This disease rarely shows any physical symptoms until late stages and no known biomarkers are available for early detection. Because ovarian cancer is rarely detected early, the physiology behind the initiation, progression, treatment, and prevention of this disease remains largely unclear. Over the past 2 decades, the laying hen has emerged as a model that naturally develops epithelial ovarian cancer that is both pathologically and histologically similar to that of the human form of the disease. Different molecular signatures found in human ovarian cancer have also been identified in chicken ovarian cancer including increased CA125 and elevated E-cadherin expression, among others. Chemoprevention studies conducted in this model have shown that decreased ovulation and inflammation are associated with decreased incidence of ovarian cancer development. The purpose of this article is to review the major studies performed in laying hen model of ovarian cancer and discuss how these studies shape our current understanding of the pathophysiology, prevention, and treatment of epithelial ovarian cancer.
Influence of mTOR-inhibitors and mycophenolic acid on human cholangiocellular carcinoma and cancer associated fibroblasts (2016)

The secretion of proinflammatory cytokines by CAFs may lead to increased activation of JAK/STAT3-, ERK- and AKT-signaling and increased migration of CCA-cells. Everolimus abrogates this effect and inhibits proliferation of CCA-cells even at low concentrations. LTx for non-resectable early stage CCA is currently performed in several clinical studies. Consistent with a role for common immunosuppressants in inhibiting tumour cell-proliferation and -invasion, our study indicates that a combination of standard therapies with Everolimus and MPA is a promising therapy option to treat CCA following LTx.
Transmission of IP over InfiniBand (IPoIB) (2006)

This document specifies a method for encapsulating and transmitting
IPv4/IPv6 and Address Resolution Protocol (ARP) packets over
InfiniBand (IB). It describes the link-layer address to be used when
resolving the IP addresses in IP over InfiniBand (IPoIB) subnets. The
document also describes the mapping from IP multicast addresses to
InfiniBand multicast addresses. In addition, this document defines the
setup and configuration of IPoIB links. [STANDARDS-TRACK]
Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome (1997)

KIF (kinesin superfamily) proteins are microtubule-dependent molecular motors that play important roles in intracellular transport and cell division. The extent to which KIFs are involved in various transporting phenomena, as well as their regulation mechanism, are unknown. The identification of 16 new KIFs in this report doubles the existing number of KIFs known in the mouse. Conserved nucleotide sequences in the motor domain were amplified by PCR using cDNAs of mouse nervous tissue, kidney, and small intestine as templates. The new KIFs were studied with respect to their expression patterns in different tissues, chromosomal location, and molecular evolution. Our results suggest that (i) there is no apparent tendency among related subclasses of KIFs of cosegregation in chromosomal mapping, and (ii) according to their tissue distribution patterns, KIFs can be divided into two classes-i.e., ubiquitous and specific tissue-dominant. Further characterization of KIFs may elucidate unknown fundamental phenomena underlying intracellular transport. Finally, we propose a straightforward nomenclature system for the members of the mouse kinesin superfamily.
Reduction in Packet Delay Through the use of Common Buffer over Distributed Buffer in the Routing Node of NOC Architecture (2013)

Performance evaluation of the routing node in terms of latency is the characteristics of an efficient design of Buffer in input module. It is intended to study and quantify the behavior of the single packet array design in relation to the multiple packet array design. The utilization efficiency of the packet buffer array improves when a common buffer is used instead of individual buffers in each input port. First Poissons Queuing model was prepared to manifest the differences in packet delays. The queuing model can be classified as (M/M/1), (32/FIFO). Arrival rate has been assumed to be Poisson distributed with a mean arrival rate of 10 x 1000000. The service rate is assumed to be exponentially distributed with a mean service rate of 10.05 x 1000000. It has been observed that latency in Common Buffer improved by 46 percent over its distributed buffer. A Simulink model later simulated on MATLAB to calculate the improvement in packet delay. It has been observed that the delay improved by approximately 40 percent through the use of a common buffer. A verilog RTL for both common and shared buffer has been prepared and later synthesized using Design Compiler of SYNOPSYS. In distributed buffer, arrival of data packet could be delayed by 2 or 4 clock cycles which lead to latency improvement either by 17 percent or 34 percent in a common buffer
Local Approach to Thermally-Sprayed Coating/Substrate Adhesion through LASAT (Laser Shock Adhesion Test) (2007)

Three interface factors may influence thermally-sprayed coatings adhesion: interface morphology (as usual), thermal and chemical features. It was shown that these three aspects of adhesion mechanisms are shown to be dependent and very local. It is especially true for cold spray which is one of the most promising spray processes. As this spraying technique is based on rapid deformation, cold spray coating/substrate interfaces show local morphological, thermal and chemical features, in a way that none of them can be neglected. LASAT is particularly suitable for testing these coatings because it can be applied to small areas (~1 mm²). From this, it has the outstanding advantage to be sensitive to fine-scaled phenomena responsible for coating adhesion.
Spin-Orbital Excitations in Ca2RuO4 Revealed by Resonant Inelastic X-Ray Scattering (2018)

The strongly correlated insulator Ca2RuO4 is considered as a paradigmatic realization of both spin-orbital physics and a band-Mott insulating phase, characterized by orbitally selective coexistence of a band and a Mott gap. We present a high resolution oxygen K-edge resonant inelastic x-ray scattering study of the antiferromagnetic Mott insulating state of Ca2RuO4. A set of low-energy (about 80 and 400 meV) and high-energy (about 1.3 and 2.2 eV) excitations are reported, which show strong incident light polarization dependence. Our results strongly support a spin-orbit coupled band-Mott scenario and explore in detail the nature of its exotic excitations. Guided by theoretical modeling, we interpret the low-energy excitations as a result of composite spin-orbital excitations. Their nature unveils the intricate interplay of crystal-field splitting and spin-orbit coupling in the band-Mott scenario. The high-energy excitations correspond to intra-atomic singlet-triplet transitions at an energy scale set by Hund’s coupling. Our findings give a unifying picture of the spin and orbital excitations in the band-Mott insulator Ca2RuO4.
Non-Solid Explosives for Shaped Charges I: Explosive Parameters Measurements for Sensitized Liquid Explosives (2007)

The disposal of time-expired and unexploded ordnance is a major problem for the NATO countries. Simple functioning of the device, either in its design mode or by attachment of additional explosive and firing, requires extended safety zones. Inducing deflagration could reduce co-lateral damage within the safety zone. One solution to the problem, with current explosive fillings, of producing predictable performance devices for EOD work is to use liquid explosives in shaped charges. This article reports measurement of explosive performance of sensitized nitromethane, a cheap, non-detonator-sensitive liquid. Sensitization was achieved either by adiabatic gas compression, using microballoon collapse, or by a combination of trapped air bubbles in a porous polymer foam, and the chemical nature of the foam. Nitrogen-containing polyurethane foams were superior to oxygen-containing polyester foams. The results show the velocity of detonation of nitromethane is proportional to the nitromethane density in the sample rather than sample density; i.e., type I behavior. Results are promising in terms of reliability, reproducibility, and performance to encourage further investigation against EOD targets.
GhERF‐IIb3 regulates the accumulation of jasmonate and leads to enhanced cotton resistance to blight disease (2016)

The phytohormone jasmonic acid (JA) and its derivatives, collectively referred to as jasmonates, regulate many developmental processes, but are also involved in the response to numerous abiotic/biotic stresses. Thus far, powerful reverse genetic strategies employing perception, signalling or biosynthesis mutants have broadly contributed to our understanding of the role of JA in the plant stress response and development, as has the chemical gain-of-function approach based on exogenous application of the hormone. However, there is currently no method that allows for tightly controlled JA production in planta. By investigating the control of the JA synthesis pathway in bacteria-infected cotton (Gossypium hirsutum L.) plants, we identified a transcription factor (TF), named GhERF-IIb3, which acts as a positive regulator of the JA pathway. Expression of this well-conserved TF in cotton leaves was sufficient to produce in situ JA accumulation at physiological concentrations associated with an enhanced cotton defence response to bacterial infection.
Development of new high temperature power generating couples for the Advanced Thermoelectric Converter (ATEC) (2010)

Radioisotope Thermoelectric Generators (RTGs) have served as a reliable source of space power for decades, enabling robotic spacecraft to explore regions of the Solar System where photovoltaic systems are impractical. The increased power requirements for future missions, combined with the reduced availability of radioisotope fuel, has prompted the development of a higher specific power, higher efficiency converter system employing thermocouples with advanced thermoelectric materials. The challenges in incorporating these advanced materials into power generating thermocouples suitable for operation in a space-rated RTG are discussed herein.