gebhart/patrepeval huggingface dataset:
Pressure On Plasticizers (2015)

RETURN TO ISSUEPREVNewsNEXTPressure On PlasticizersView Author Information C&EN WashingtonCite this: Chem. Eng. News 2015, 93, 25, 11–15Publication Date (Print):June 22, 2015Publication History Published online30 March 2016Published inissue 22 June 2015https://pubs.acs.org/doi/10.1021/cen-09325-cover2https://doi.org/10.1021/cen-09325-cover2newsACS PublicationsCopyright © 2015 Chemical & Engineering NewsArticle Views18Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Organic compounds Get e-Alerts
Novel chemical sensors using boronic acids for glucose detection (2017)

Boronic acids (BAs) are well-­known for their interactions with diol-­containing compounds like glucose. Fluorescent moieties are commonly considered to enable monitoring of this interaction by changes in fluorescence. Incorporation of a BA component into charged molecules, can be used to induce quenching in the emission of a fluorescent molecule, thereby creating a two-­component sensing system1-­2. Hence, a novel cationic pyrimidine BA derivative, PBA, has been investigated for its indirect glucose sensing capabilities. In this approach, the fluorescence of 7-­hydroxycoumarin (7HC) is monitored. Increasing concentrations of our novel PBA sensor, quenches the fluorescence of 7HC by 98% (Fig. 1A). The decrease in fluorescence intensity of the system is achieved through electrostatic and p-­p stacking interactions between the fluorophore and PBA-­quencher1-­2. In the presence of saccharides, the Lewis acidic BA moiety of the sensor is known to form strong, reversible interactions2. This leads to the formation of an anionic boronate diester2, resulting in the dissociation of the BA-­quencher and fluorophore complex, causing a sequential recovery of fluorescence in 7HC1-­2 by 16% (Fig. 1B). This glucose-­sensing switch can be used to&#13;\nindirectly quantify glucose concentrations. Moreover, the inclusion of anchoring moieties in to the PBA-­quencher shows potential for the incorporation of this molecule into soft hydrogel platforms.
A Study on the Images of Fashion Advertisements using Mirrors (2009)

Mirrors often appear in fashion advertisements. This study aimed to analyze meanings of the images represented in fashion advertisements using mirrors. This study analyzed the meanings of mirror image in Western art history, and also studied meanings of female representations in the paintings. Based on previous studies, this study classified mirrors' expressions in three types and analyzed their meanings. To analyze the meanings of the three types, this study researched the symbolic meanings of the mirrors in visual arts chronologically, first. And then, this study interpreted that in the context of consumption cultures and consuming ideologies in view of feminism, consumption ideology, desire theory, and fetishism. The results of this study were as follows; 1. Narcistic body expressions associated with strong and independent women, while associated submissive being overwhelmed by consumption cultures. 2. The method of revealing the female body throughout mirrors was meant to attract the attention of consumer. 3. Multiplied body images meaning was like a commodity in fashion advertisements.
Talking About Security with Professional Developers (2019)

This paper describes materials developed to engage professional developers in discussions about security. First, the work is framed in the context of ethnographic studies of software development, highlighting how the method is used to explore and investigate research aims for the Motivating Jenny research project. A description is given of a series of practitioner engagements, that were used to develop a reflection and discussion tool using security stories taken from media and internet sources. An explanation is given for how the tool has been used to collect data within field sites, offering a way to clarify and member check findings, and to provide a different view on practice and process. The report concludes with observations and notes about future aims for supporting and encouraging professionals to engage with security in practice.
Variability and energy awareness: a microarchitecture-level perspective (2005)

This paper proposes microarchitecture-level models for Within Die (WID) process and system parameter variability that can be included in the design of high-performance processors. Since decisions taken at microarchitecture level have the largest impact on both performance and power, on one hand, and global variability effect, on the other hand, models and associated metrics are needed for their joint characterization and analysis. To assess how these variations affect or are affected by microarchitecture decisions, we propose a joint performance, power and variability metric that is able to distinguish among various design choices. As a design-driver for the modeling methodology, we consider a clustered high-performance processor implementation, along with its Globally Asynchronous, Locally Synchronous (GALS) counterpart. Results show that, when comparing the baseline, synchronous and its GALS counterpart, microarchitecture-driven impact of process variability translates into 2-10% faster local clocks for the GALS case, while when taking into account the effect of on-chip temperature variability, local clocks can be 8-18% faster. If, in addition, voltage scaling (DVS) is employed, the GALS architecture with DVS is 26% better in terms of the joint quality metric employing energy, performance, and variability.
Future Directions for the Implementation and Dissemination of Statewide Developmental-Behavioral Pediatric Integrated Health Care (2016)

The integration of mental health and pediatric health care services has long been a goal for both research and practice. With the advent of federal policies developed to mandate clinical efficiency across the health care spectrum, this issue is becoming more salient. Applied literature on this topic is only recently emerging, however, and there are limited contextual examples to guide program development, research, and refinement. This article presents background information relevant to the development of such a program (the Center for Advancement of Youth). The cultural and organizational contexts for the project are discussed, with particular emphasis on models for cooperation among several institutions of varying size and scope. The implications for the future of tangible research in this area are also discussed, with attention to extending lessons learned to diverse settings motivated to integrate various aspects of health care service provision.
Abstract 12024: Generalizability of the CASTLE-AF Trial: Assessing Outcomes of Catheter Ablation for Patients With Atrial Fibrillation and Heart Failure in Routine Practice (2018)

Introduction: In the CASTLE-AF trial, catheter ablation reduced the risk of death and heart failure (HF) hospitalization in patients with atrial fibrillation (AF) and HF by nearly 40%. We aimed to ...
Codes in the Lee Metric (2006)

The study of error-correcting codes concentrates primarily on codes in the Hamming metric. Such codes are designed to correct a prescribed number of errors, where by an error we mean a change of an entry in the transmitted codeword, irrespective of the (nonzero) error value. The assignment of the same weight to each nonzero error value is reflected also in the model of the q-ary symmetric channel, where all nonzero error values occur with the same probability.
ChemInform Abstract: Synthesis of Enantiomerically Pure Stereogenically Labile 4‐Aryl‐2‐ hydroxytetronic Acids (VII) from Enantiomerically Pure Silyl‐Protected Mandelaldehydes: aci‐Reductone Analogues of Propionic Acid Nonsteroidal Antiinflammatory Agents. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cloud data systems (2022)

The panel will discuss the research opportunities for the database research community in the context of cloud native data services.
The art of sealing base metals through glass (1923)

Methods are described by which base metals may be sealed to and through glass, even though the metal and glass have different coefficients of thermal expansion. The method consists in providing a large surface of contact between the glass and the metal, and in so proportioning the metal that the stresses resulting from the difference in coefficients of expansion are less than the ultimate strength of the joint between glass and metal. Four different types of seals are discussed: First, the flattened wire seal for small electrical conductors. Second, the ribbon seal for special purposes. Third, the disk seal for commercial manufacture of seals for carrying currents of the order of 100 amperes. Fourth, the tube seal in which metal and glass tubing are joined together.
Relative notch opening displacement concept for crack initiation in high temperature time dependent fracture of stainless steel. (1985)

ステンレス鋼切欠きからのき裂発生時の相対切欠開口変位(RNOD)は,高温クリープ,疲労およびクリープ疲労の重量のすべてに共通して,切欠形状,試片幅,空気中ないし真空中によらず,公称応力および温度にのみ若干依存し,ほとんど一定の値を取る.定常クリープを示す応力・温度のもとでは,RNODの値はほぼ0.25～0.38の範囲をとる.切欠形状や試片幅によって,き裂の発生や進展は,安定,不安定挙動といった異なる挙動を示すにもかかわらず,RNODのほうはこれに無関係に唯一性を示す.
Expression and Mutagenesis of the Novel Serpin Endopin 2 Demonstrates a Requirement for Cysteine-374 for Dithiothreitol-Sensitive Inhibition of Elastase (2000)

The primary sequence of the serpin endopin 2 predicts a reactive site loop (RSL) region that possesses high homology to bovine elastase inhibitor, suggesting inhibition of elastase. Moreover, endopin 2 possesses two cysteine residues that implicate roles for reduced Cys residue(s) for inhibitory activity. To test these predicted properties, mutagenesis and chemical modification of recombinant endopin 2 were performed to examine the influence of dithiothreitol (DTT), a reducing agent, on endopin 2 activity. Endopin 2 inhibited elastase in a DTT-dependent manner, with enhanced inhibition in the presence of DTT. The stoichiometry of inhibition in the presence of DTT occurred at a molar ratio of endopin 2 to elastase of 8/1, resulting in complete inhibition of elastase. However, a higher molar ratio (25/1) was required in the absence of DTT. DTT enhanced the formation of SDS-stable complexes of endopin 2 and elastase, a characteristic property of serpins. Site-directed mutagenesis of endopin 2, with substitution of Ala for Cys-232 or Cys-374, demonstrated that Cys-374 (but not Cys-232) was required for the DTT-sensitive nature of endopin 2. Chemical modification of Cys-374 by bis(maleimido)ethane also reduced inhibitory activity. Modified electrophoretic mobilities of mutant endopin 2 suggested the presence of intramolecular disulfide bonds; in addition, chemical modification suggested that Cys-374 influences the electrophoretic and conformational properties of endopin 2. Moreover, the reducing agent glutathione enhanced endopin 2 activity, suggesting that glutathione can function as an endogenous reducing agent for endopin 2 in vivo. These findings demonstrate the importance of Cys-374 for DTT-sensitive inhibition of elastase by endopin 2.
Effect of a Saline on Acute Kidney Injury among Patients in the Intensive Care Unit (2016)

be addressed. First, a total of 60% of the enrolled patients underwent elective surgery, and fluid resuscitation is rarely indicated for such patients. Furthermore, only 4% of the enrolled patients had sepsis or trauma, which usually requires fluid resuscitation. Therefore, this study population is not representative of the critically ill patients who generally need fluid therapy, and the study fluid may thus be used only as a maintenance fluid and not as a resuscitation fluid. Second, because of the above-mentioned reason, each study fluid was infused at a median volume of 1,200∼1,400 ml on day 0 and 40∼90 ml on day 1. A small amount of 0.9% saline solution will not induce hyperchloremia and metabolic acidosis, or will induce very short-term hyperchloremia (2). The mechanism of 0.9% saline-induced renal dysfunction is that infusion of a supraphysiological concentration of chloride induces hyper- chloremia, which, in turn, causes renal vasoconstriction and decreased glomerular filtration rate (3). Therefore, the small amount of infused saline in this study may not induce hyper- chloremia and renal dysfunction. However, this study did not show data about the serum chloride level or acid-base balance of the study population. Third, because the primary outcome of this study was renal dysfunction, patients with renal dysfunction were excluded. However, a large proportion of critically ill patients usually have variable grades of renal dysfunction, and saline may cause a higher degree of hyperchloremia and may have a more harmful effect to critically ill patients in general than to the study population. In conclusion, the use of fluid therapy in the population of this study is not representative of the situation of resuscitation or fluid therapy in general intensive care units. Randomized controlled trials are needed to compare the use of 0.9% saline and buffered fluid as a resuscitation fluid in high-risk or critically ill patients with shock before drawing a definitive conclusion.
Anabolic steroids and semen parameters in bodybuilders (1989)

Journal Article Anabolic steroids and semen parameters in bodybuilders Get access U A Knuth, U A Knuth Max-Planck-Gesellschaft, Klinische Forschungsgruppefür Reproduktionsmedizin und Institut für Reproduktionsmedizin, Westfälische Wilhelms-Universität, Münster Search for other works by this author on: Oxford Academic Google Scholar H Maniera, H Maniera Max-Planck-Gesellschaft, Klinische Forschungsgruppefür Reproduktionsmedizin und Institut für Reproduktionsmedizin, Westfälische Wilhelms-Universität, Münster Search for other works by this author on: Oxford Academic Google Scholar E Nieschlag E Nieschlag Max-Planck-Gesellschaft, Klinische Forschungsgruppefür Reproduktionsmedizin und Institut für Reproduktionsmedizin, Westfälische Wilhelms-Universität, Münster Search for other works by this author on: Oxford Academic Google Scholar Acta Endocrinologica (Norway), Volume 120, Issue 3_Supplement, Jun 1989, Pages S121–S122, https://doi.org/10.1530/acta.0.120S121 Published: 01 June 1989
[Qualitative and quantitative characteristics of fibers of the gastrocnemius and pectoral muscles of the chicken embryo]. (2000)

The electron microscopic study shows that in 10 days chick embryo parenchymal elements of the gastrocnemius and pectoralis muscles are myotubes with sparse mitochondria, and that they do not differ morphologically. Up to the 18th day in ovo muscle fibers in the future oxidative muscle grow up faster than those in the future glycolytic one. There is no relation between the mitochondrial density and distribution within sarcoplasm and the capillary location but they are in good correlation with the myofibrillar parameters. As muscle fibers mature the energy delivery of myofibrils (mitochondria-to-myofibrils volume density ratio) increases due to mitochondrial density rather than their size.
Role of Diacylglycerol in PKD Recruitment to the TGN and Protein Transport to the Plasma Membrane (2002)

Protein kinase D (PKD) is a cytosolic serine-threonine kinase that binds to the trans-Golgi network (TGN) and regulates the fission of transport carriers specifically destined to the cell surface. PKD was found to bind diacylglycerol (DAG), and this binding was necessary for its recruitment to the TGN. Reducing cellular levels of DAG inhibited PKD recruitment and blocked protein transport from the TGN to the cell surface. Thus, a DAG-dependent, PKD-mediated signaling regulates the formation of transport carriers from the TGN in mammalian cells.
Quantitative Changes of Bone Volume and Immunohistochemical Analysis of Biomarkers in Healthy, Osteoporotic and Osteoporotic Sham Surgery Affected Rabbit Bone Controls (2016)

Aim of our preliminary in vivo study was to evaluate bone regeneration properties in three different bone conditions and to compare expression of OPG, NFkB105, BMP2/4, MMP2, IL 1 and IL 10 between healthy, osteoporotic and osteoporotic sham surgery affected rabbit bone controls. Osteoporosis index was found to be higher in healthy bone, while rabbits with osteoporotic sham surgery affected bone showed slight elevation of mean trabecular field rather than rabbits with osteoporotic bone. Expression of OPG and NFkB105 was higher in healthy bone, with less equal appearance in osteoporotic and osteoporotic sham surgery affected bone. Presence of BMP2/4 and MMP2 was much higher in healthy bone, whereas twice less in osteoporotic group. Osteoporotic sham surgery affected group showed recurrence of immunoreactive structures similar to healthy group of IL 1 and IL 10. OPG and was found as the most stable indicators for bone regeneration. Decrease of BMP2/4, MMP2, IL-1 and 1L-10 in osteoporotic bone with following increase in osteoporotic sham surgery affected bone, proves the role of traumatic injury as the inducer of bone regeneration.
Retrospective motion correction with structural priors for clinical MRI protocols (2023)

We present a retrospective rigid motion correction and reconstruction scheme for brain MRI with the aid of structural priors. The proposed framework is designed to be applied to a clinical protocol including multiple scans for multiple contrasts, of which some scans are corrupted due to motion during the acquisitions, but at least one is uncorrupted and exploited as an additional prior. We envision a practical workflow that can easily fit into the existing clinical practice without the need for changing the MRI acquisition protocols.
Loss of glycocalyx barrier properties impairs insulin‐mediated recruitment of microvascular blood volume in rat hind limb muscle (2010)

Experimental data suggest that a rapid increase in capillary blood volume underlies the insulin‐mediated glucose uptake in skeletal muscle. We hypothesize that loss of glycocalyx properties impairs the ability of insulin to increase microvascular blood volume in skeletal muscle. In anesthetized rats, the hind limb muscle microcirculation was visualized with a Sidestream Dark Field camera before and during a 30 minute infusion of insulin (6mU/min/kg). Median values and dynamic range of red blood cell (RBC) column widths were measured to determine functional microvascular diameters and glycocalyx barrier function, respectively. In control rats (n=5), insulin infusion increased within five minutes the dynamic range of RBC width with 0.56 μm ± 0.19 μm (mean ± SEM) (P&lt;0.05). Hereafter, microvascular diameter increased with 0.69 μm ± 0.22 μm (P&lt;0.05), while the dynamic range of RBC width returned to pre‐insulin values. In rats, in which the glycocalyx was degraded with a bolus of hyaluronidase (500U; n=7), the dynamic range was already increased at baseline levels with 0.30 μm ± 0.02 μm (p&lt;0.05), with no further effect of insulin. Rapid insulin‐mediated increases in microvascular blood filling in rat skeletal muscle appear to be preceeded by an attenuation of glycocalyx barrier properties. This ability of insulin is impaired after enzymatic degradation of the glycocalyx. Supported by DFN 2006.00.027 and NHF 2005T037
Pneumotox - An updated time-saving web resource (2013)

Pneumotox was designed in 1997 to provide health professionals with a free, quick-access, regularly updated and maintained database on any respiratory disease. These features were thought to be essential, as some drug-induced respiratory diseases can progress quickly and can be immediatedly life-threatening. Hence, instant information at the point of care is needed. Therefore, Pneumotox is now accessible from any PC, Ipad, Android tablet and smartphone for free. Methods: Pneumotox was fed with a backup list now amounting to of 17.700 references. All languages were considered. Papers received adequate keywording using internationally recognized classifications and wording of diseases. Accretion of articles from PubMed started in 1978. Relevant articles (n=5327) were included in the web-user side of Pneumotox. Search on Pneumotox was compared with search on Pubmed in selected situations. Resultts: Crude number of reports were (Pneumotox vs. Pubmed) 'drug-induced pulmonary disease (5521/2451), drug-induced pleural effusion (628/92), methotrexate lung 529/481), drug-induced histopathology (2403/588), amiodarone pulmonary toxixity (744/574), drug-induced angioedema (261/99). Time spent to build a list of drugs causing a potentially fatal adverse reaction (acute interstitial lung disease, pulmonary edema/hemorrhage, acute airway obstruction, anaphylaxis), acute pulmonary hypertension, respiratory muscle paralysis, methemoglobinemia) was unquestionably shorter using Pneumotox compared to PubMed by several orders of magnitude. Conclusion: The web resource Pneumotox presents extensive information on drug-induced respiratory disorders. This information is obtained in shorter times, compared to conventional sources.
Correlations in Social Neuroscience Aren't Voodoo: Commentary on Vul et al. (2009) (2009)

Vul, Harris, Winkielman, and Pashler (2009) , (this issue) claim that many brain—personality correlations in fMRI studies are “likely … spurious” (p. 274), and “should not be believed” (p. 285). Several of their conclusions are incorrect. First, they incorrectly claim that whole-brain regressions use an invalid and “nonindependent” two-step inferential procedure, a determination based on a survey sent to researchers that only included nondiagnostic questions about the descriptive process of plotting one's data. We explain how whole-brain regressions are a valid single-step method of identifying brain regions that have reliable correlations with individual difference measures. Second, they claim that large correlations from whole-brain regression analyses may be the result of noise alone. We provide a simulation to demonstrate that typical fMRI sample sizes will only rarely produce large correlations in the absence of any true effect. Third, they claim that the reported correlations are inflated to the point of being “implausibly high.” Though biased post hoc correlation estimates are a well-known consequence of conducting multiple tests, Vul et al. make inaccurate assumptions when estimating the theoretical ceiling of such correlations. Moreover, their own “meta-analysis suggests that the magnitude of the bias is approximately .12—a rather modest bias.