gebhart/patrepeval huggingface dataset:
Transactivation of ErbB2 and ErbB3 by Tumor Necrosis Factor-α and Anisomycin Leads to Impaired Insulin Signaling through Serine/Threonine Phosphorylation of IRS Proteins (2002)

The cellular pathways involved in the impairment of insulin signaling by cellular stress, triggered by the inflammatory cytokine tumor necrosis factor-alpha (TNF) or by translational inhibitors like cycloheximide and anisomycin were studied. Similar to TNF, cycloheximide and anisomycin stimulated serine phosphorylation of IRS-1 and IRS-2, reduced their ability to interact with the insulin receptor, inhibited the insulin-induced tyrosine phosphorylation of IRS proteins, and diminished their association with phosphatidylinositol 3-kinase (PI3K). These defects were partially reversed by wortmannin and LY294002, indicating that a PI3K-regulated step is critical for the impairment of insulin signaling by cellular stress. Induction of cellular stress resulted in complex formation between PI3K and ErbB2/ErbB3 and enhanced PI3K activity, implicating ErbB proteins as downstream effectors of stress-induced insulin resistance. Indeed, stimulation of ErbB2/ErbB3 by NDFbeta1, the ErbB3 ligand, inhibited IRS protein tyrosine phosphorylation and recruitment of downstream effectors. Specific inhibitors of the ErbB2 tyrosine kinase abrogated the activation of ErbB2/ErbB3 and in parallel prevented the reduction in IRS protein functions. Taken together, our results suggest a novel mechanism by which cellular stress induces cross-talk between two different signaling pathways. Stress-dependent transactivation of ErbB2/ErbB3 receptors triggers a PI3K cascade that induces serine phosphorylation of IRS proteins culminating in insulin resistance.
Enterohaemorrhagic E. coli modulates an ARF6:Rab35 signaling axis to prevent recycling endosome maturation during infection (2016)

Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC/EHEC) manipulate a plethora of host cell processes to establish infection of the gut mucosa. This manipulation is achieved via the injection of bacterial effector proteins into host cells using a Type III secretion system. We have previously reported that the conserved EHEC and EPEC effector EspG disrupts recycling endosome function, reducing cell surface levels of host receptors through accumulation of recycling cargo within the host cell. Here we report that EspG interacts specifically with the small GTPases ARF6 and Rab35 during infection. These interactions target EspG to endosomes and prevent Rab35-mediated recycling of cargo to the host cell surface. Furthermore, we show that EspG has no effect on Rab35-mediated uncoating of newly formed endosomes, and instead leads to the formation of enlarged EspG/TfR/Rab11 positive, EEA1/Clathrin negative stalled recycling structures. Thus, this paper provides a molecular framework to explain how EspG disrupts recycling whilst also reporting the first known simultaneous targeting of ARF6 and Rab35 by a bacterial pathogen.
European Society of ColoProctology: guideline for haemorrhoidal disease (2020)

This international, multidisciplinary guideline provides an up to date and evidence based summary of the current knowledge of the management of HD and may serve as a useful guide for patients and clinicians.
Risk Factors of Delayed Extubation, Prolonged Length of Stay in the Intensive Care Unit, and Mortality in Patients Undergoing Coronary Artery Bypass Graft with Fast-Track Cardiac Anesthesia: A New Cardiac Risk Score (2000)

WONG, DAVID T.; CHENG, DAVY C.H.; KUSTRA, RAFAL; TIBSHIRANI, ROBERT; KARSKI, JACEK; CARROLL-MUNRO, JO; SANDLER, ALAN Author Information
ChemInform Abstract: An ab initio Study of the P‐C Bond Rotation in Phosphoryl‐ and Thiophosphoryl‐Stabilized Carbanions: Five‐ and Six‐Membered Heterocycles. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Study on the Relation Between Rubbing Conditions and Physical Parameters of Polyimide (2011)

Physical parameters on polyimide (PI) surfaces were investigated via spectroscopic techniques as a function of ROLLER ROTATION SPEED and STAGE MOVING SPEED of a rubbing process. The observed parameters exhibited the following trends; the parameters, such as anchoring energy and induced anisotropy, were enhanced as ROLLER ROTATION SPEED and STAGE MOVING SPEED increased until an optimal condition was reached. However, the parameters reversely degraded as those increased over optimal value of treating condition. From Raman spectroscopic measurements, we confirmed that strongly rubbing-treated PI over optimal condition was chemically degraded, resulting in degrading the parameters of PI.
Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods (2011)

The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H(2)O(2) and O(2)·-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H(2)O(2) and a HPLC method for the determination of O(2)·- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (fli1a:EGFP) zebrafish embryos.
Effects of hydrogen on magnetic properties of amorphous zirconium alloys (1985)

The magnetic susceptibilities χ(T) of the amorphous ternary hydrides of the paramagnetic metallic glasses a-Zr2Pd and a-Zr3Rh have been measured between 7 and 300 K. It has been found that χ(T) of both a-Zr2PdHx and a-Zr3RhHx decrease substantially with increasing hydrogen content. This behavior is primarily attributed to reductions in the densities of the Fermi level electronic states. Although χ(T) for crystalline Zr2Pd (MoSi2 structure type) is smaller than the susceptibility of the a-Zr2Pd glass, χ(T) for a crystallized Zr3Rh sample was found to increase relative to the initial susceptibility for this glass.
Challenges to Complementary and Alternative Medical Research: Focal Issues Influencing Integration Into a Cancer Care Model (2005)

Complementary and alternative therapies are increasingly used by cancer patients for palliative and postcancer preventive and/or wellness care. It is critical that evidence-based models be employed to both provide information for patients' use and informed consent and for physicians to advise patients and assess relative risk:benefit ratios of using specific complementary and alternative medicine (CAM) approaches within the cancer care paradigm. Research models for biomedicine have been somewhat limited when applied to broader, more holistic conceptualizations of health common to many forms of CAM. Thus, while numerous challenges to studying CAM exist, a fundamental question is not just what CAM practices should be studied but how CAM should be studied. The authors propose a model that emphasizes methodologic rigor yet approaches CAM research according to relative levels of evidence, meaning, and context, ranging from experimental, quantitative studies of mechanism to qualitative, observational studies of noetic/salutogenic variables. Responsibility for training researchers prepared to meet such challenges rests on both CAM and mainstream academic institutions, and care must be taken to avoid philosophical and practical pitfalls that might befall a myopic perspective of integration.
The cytoplasmic domain of adherens‐type junctions (1991)

Adherens junctions (AJ) comprise a unique and widespread family of cellular contacts which displays a stable association, within the cells, with actin-containing microfilaments [Geiger et al., 19871. As discussed in several previous articles They may be found in areas of plasmallemal contact with the surrounding extracellular matrix (ECM) as well as in regions of apparently direct intercellular interactions
Long-Term Prognosis of Patients With Kawasaki Disease Complicated by Giant Coronary Aneurysms (2011)

The long-term survival of patients with Kawasaki disease complicated by giant coronary aneurysms is moderately good with multiple catheter and surgical interventions. Further research should focus on the prevention of coronary vascular remodeling and on the indications for and effectiveness of percutaneous and surgical coronary interventions.
The effect of adjuvants and delivery systems on Th1, Th2, Th17 and Treg cytokine responses in mice immunized with Mycobacterium tuberculosis-specific proteins (2020)

Tuberculosis (TB) is a major health problem of global concern. The control of this disease requires appropriate preventive measures, including vaccines. In TB, T helper (Th)1 cytokines provide protection whereas Th2 and T regulatory (Treg) cytokines contribute to the pathogenesis and Th17 cytokines play a role in both protection and pathogenesis. Previous studies with Mycobacterium tuberculosis-specific proteins have identified seven low molecular weight proteins, PE35, ESXA, ESXB, Rv2346c, Rv2347c, Rv3619c, and Rv3620c, as immunodominant antigens inducing Th1-cell responses in humans following natural infection with M. tuberculosis. The aim of this study was to characterize the cytokine responses induced in mice immunized with these proteins, using various adjuvants and delivery systems, i.e. chemical adjuvants (Alum and IFA), non-pathogenic mycobacteria (M. smegmatis and M. vaccae) and a DNA vaccine plasmid (pUMVC6). The immune responses were monitored by quantifying the marker cytokines secreted by Th1 (IFN-ɣ), Th2 (IL-5), Treg (IL-10), and Th17 (IL-17A) cells. DNA corresponding to pe35, esxa, esxb, rv2346c, rv2347c, rv3619c, and rv3620c genes were cloned into the expression vectors pGES-TH-1, pDE22 and pUMVC6 for expression in Escherichia coli, mycobacteria and eukaryotic cells, respectively. Mice were immunized with the recombinants using different adjuvants and delivery systems, and spleen cells were stimulated in vitro with peptides of immunizing proteins to investigate antigen-specific secretion of Th1 (IFN-ɣ), Th2 (IL-5), Treg (IL-10), and Th17 (IL-17A) cytokines. The results showed that spleen cells, from mice immunized with all antigens, secreted the protective Th1 cytokine IFN-ɣ, except ESXB, with one or more adjuvants and delivery systems. However, only Rv3619c consistently induced Th1-biased responses, without the secretion of significant concentrations of Th2, Th17 and Treg cytokines, with all adjuvants and delivery systems. Rv3619c also induced antigen-specific IgG antibodies in immunized mice.
Sebaceous adenitis in the Akita: clinical observations, histopathology and heredity (2001)

Ninety-seven pure-bred Akitas were examined clinically and histologically for sebaceous adenitis. The diagnosis was established histologically in 23 Akitas by demonstrating an inflammatory reaction targeted against the sebaceous glands or a reduction in the number of glands. The clinical course of sebaceous adenitis in the Akita was similar to that seen in other breeds. The first skin lesions occurred mainly on the dorsal midline and ears. Compared with the Poodle, the age at first onset of the disease was more variable and the hair loss affected mainly the undercoat. The progression of sebaceous gland destruction varied between dogs and was not seen in all cases. Because bud-like sebaceous gland proliferation could be identified, it seems that regeneration of the sebaceous glands may occur. An autosomal recessive inheritance appears to be possible. Apart from a genetic background, immune-mediated factors possibly influence the onset and course of sebaceous adenitis.
Refractive and Chiroptical Properties of Clinical Dextrans (2006)

The refractive index dispersion and optical rotatory dispersion of two clinical dextrans is discussed. Temperature dependence of n and specific rotation do not show evidence of conformational phase transition in the temperature range of 278 ÷ 347 K. Two characteristic concentrations for both dextrans were observed. One with c ~ 0.02 g/dL and second with c ~ 2 g/dL which may be related with an aggregation and an overlapping processes of polymer chains respectively. Negligible influence of K + and Ca 2+ ions on conformational structure of dextran polymer chain was found.
The effect of chronic and acute haemorrhage on erythropoietin in the neonatal lamb. (1992)

In all mammalian species studied the haematocrit (hct) declines after birth in the absence of any known nutritional deficiencies. The glycoprotein hormone, erythropoietin (Epo), is essential for normal red blood cell production. The aims of this study were 1) to investigate the changes in plasma Epo during the normal post-natal decrease in hct in lambs; 2) to compare the effects of chronic and acute haemorrhage in neonatal lambs; and 3) to test the hypothesis that the Epo response to haemorrhage is blunted in the neonatal period. Twenty-one lambs (0-9 weeks of age) were studied; group I (n = 8) were used to document normal post-natal changes (98 samples); group II (n = 7) lambs were haemorrhaged repetitively during weeks 3-6 (95 samples); group III (n = 6) lambs were bled once in the first 3-week period. In the group I (control lambs) the hct decreased from 30.6 +/- 1.3 (weeks 1 & 2) to a nadir of 23.2 +/- 0.8 (75.8% of initial value) in the 6th week, and the plasma Epo declined from 25.7 +/- 4.9 (week 1) to 12.3 +/- 1.0 mU/ml (week 6). In group II, the lambs were bled repetitively, a total of 510 +/- 32 ml blood being removed during weeks 3-6, the hct was 18.7 +/- 0.8 (81% of hct at nadir in controls) in week 6, and Epo was 26.9 +/- 13.3 in week 3, 23.4 +/- 3.6 mU/ml in week 6.(ABSTRACT TRUNCATED AT 250 WORDS)
Index Branch-and-Bound Algorithm for Global Optimization with Multiextremal Constraints (2011)

In this paper, Lipschitz univariate constrained global optimization problems where both the objective function and constraints can be multiextremal are considered. The constrained problem is reduced to a discontinuous unconstrained problem by the index scheme without introducing additional parameters or variables. A Branch-and-Bound method that does not use derivatives for solving the reduced problem is proposed. The method either determines the infeasibility of the original problem or finds lower and upper bounds for the global solution. Not all the constraints are evaluated during every iteration of the algorithm, providing a significant acceleration of the search. Convergence conditions of the new method are established. Test problems and extensive numerical experiments are presented.
Contribution à l'étude de la pathogénie de la mucoviscidose (1988)

Doctorat en sciences médicales
LONG PERIOD SEA‐FLOOR MULTIPLES AND THEIR SUPPRESSION* (1980)

A bstract Multiple sea‐floor reflections in deep water often are not effectively suppressed by either CDP stacking nor standard predictive deconvolution methods. These methods fail because the reflection coefficient varies markedly with angle of incidence and also because of the variation of arrival time with offset and because of dip. For a reasonablly flat sea‐floor, multiples of various orders and the primary sea‐floor reflection which have all been reflected at nearly the same angle lie along a straight line through the origin in time‐offset space. This line is called the “radial direction.” The multiples which lie along this line show a systematic relationship because they all experience the same water‐bottom reflection effect. In other words, multiples behave in a stationary manner along the radial directions on multi‐trace seismic records. A technique of multi‐channel predictive deconvolution, called “Radial Multiple Suppression,” utilizes this aspect to design Wiener operators for the prediciton and suppression of water bottom multiples. The effectiveness of the technique is demonstrated by the study of field records, autocorrelations, velocity analyses, and stacked sections before and after Radial Multiple Suppression processing.
Click synthesis of a novel triazole bridged AIE active cyclodextrin probe for specific detection of Cd2+ (2015)

A novel aggregation induced emission (AIE) active cyclodextrin (CD) was synthesized by combining tetraphenylethene (TPE) and CD via click chemistry. The new material, which is the first reported clicked AIE probe for the specific detection of Cd(2+), exhibits an excellent selective turn-on fluorescence response to Cd(2+) in neutral environments, with a low detection limit of 0.01 µM.
Prediction of the impact wear of a valve (2016)

The valves used in the oil&amp;gas industry often experience erosion due to the impingements of solids dragged by the extracted fluid. The considerable economic damages related to this phenomenon enhance the interest in techniques for predicting the location of the erosion hotsposts and the loss of material from the valve under aggressive flow conditions. CFD codes are often equipped with utilities for erosion estimation which rely on an Eulerian-Lagrangian model for two-phase flow computation and an erosion correlation for estimating the material removal caused by each particle-wall impingement. However, both the Eulerian-Lagrangian model and the erosion correlations include a number of uncertain submodels and parameterizations of empirical nature which, unless properly defined, may result in inaccurate predictions. Unfortunately, the difficulty in obtaining repeatable experimental data regarding valve erosion may hinder significant improvements in this field. This study is the first step of a research that has just started and it will soon involve the execution of experimental tests. Here we simulate the liquid-solid flow through a valve after characterizing the device in single-phase flow conditions, with the aim of finding the parameters which mainly affect the erosion estimates, in terms of identification of the area subjected to wear and quantification of the material loss. In the lack of experimental data, these parameters quantify the reliability of the erosion predictions. Moreover, the obtained numerical results will help in defining the flow conditions to be tested in our rig, in order to face the valve erosion issue from a numericalexperimental perspective.
A Hybrid Coral Reefs Optimization—Variable Neighborhood Search Approach for the Unequal Area Facility Layout Problem (2020)

The Unequal Area Facility Layout Problem (UA-FLP) is a relevant optimization problem related to industrial design, that deals with obtaining the most effective allocation of facilities, that make up the rectangular manufacturing plant layout. The UA-FLP is known to be a hard optimization problem, where meta-heuristic approaches are a good option to obtain competitive solutions. Many of these computational approaches, however, usually fall into local optima, and suffer from lack of diversity in their population, mainly due to the huge search spaces and hard fitness landscapes produced by the traditional representation of UA-FLP. To solve these issues, in this paper we propose a novel hybrid meta-heuristic approach, which combines a Coral Reefs Optimization algorithm (CRO) with a Variable Neighborhood Search (VNS) and a new representation for the problem, called Relaxed Flexible Bay Structure (RFBS), which simplifies the encoding and makes its fitness landscape more affordable. Thus, the use of VNS allows more intensive exploitation of the searching space with an affordable computational cost, as well as the RFBS allows better management of the free space into the plant layout. This combined strategy has been tested over a set of UA-FLP instances of different sizes, which have been previously tackled in the literature with alternative meta-heuristics. The tests results show very good performance in all cases.
Screening and analysis of genes expressed upon infection of broad bean with Clover yellow vein virus causing lethal necrosis (2011)

Clover yellow vein virus (ClYVV) causes lethal systemic necrosis in legumes, including broad bean (Vicia faba) and pea (Pisum sativum). To identify host genes involved in necrotic symptom expression after ClYVV infection, we screened cDNA fragments in which expression was changed in advance of necrotic symptom expression in broad bean (V. faba cv. Wase) using the differential display technique and secondarily with Northern blot analysis. Expression changes were confirmed in 20 genes, and the six that exhibited the most change were analyzed further. These six genes included a gene that encodes a putative nitrate-induced NOI protein (VfNOI), and another was homologous to an Arabidopsis gene that encodes a glycine- and proline-rich protein GPRP (VfGPRP). We recently reported that necrotic symptom development in ClYVV-infected pea is associated with expression of salicylic acid (SA)-dependent pathogenesis-related (PR) proteins and requires SA-dependent host responses. Interestingly, VfNOI and VfGPRP expression was correlated with that of the putative SA-dependent PR proteins in ClYVV-infected broad bean. However, broad bean infected with a recombinant ClYVV expressing the VfGPRP protein showed weaker symptoms and less viral multiplication than that infected with ClYVV expressing the GFP protein. These results imply that VfGPRP plays a role in defense against ClYVV rather than in necrotic symptom expression.
Development of a multifunctional TEM specimen holder equipped with a piezodriving probe and a laser irradiation port (2009)

The double-probe piezodriving specimen holder that was recently developed by some of the present authors is modified to introduce a laser irradiation port in one of its two arms. As a result, the new specimen holder consists of a piezodriving probe and a laser irradiation port, both of which can be three-dimensionally controlled by using piezoelectric elements and micrometers. While the piezodriving probe interacts with the specimen set in the holder in several ways, the laser beam causes photo-induced phenomena to occur. By performing electron holography using the new specimen holder, we demonstrate that it is possible to evaluate the change in the electric field resulting from the discharging effect of laser irradiation on organic photoconductors.
On uniform H2-estimates in periodic homogenization (2001)

We introduce what are called regular materials for which, by definition, the corresponding solution of the classical periodic homogenization problem remains bounded in . We give examples of two types of such materials depending on whether the coefficients representing them belong to W 1,∞ or not. A complete characterization is obtained in the former case.
Place for an antioxidant therapy in human immunodeficiency virus (HIV) infection (1994)

Oxidative stress, a known activator of HIV replication in vitro has a potential role as a cofactor of HIV disease progression. Arguments supporting the role of oxidative stress as a cofactor in HIV activation are summarized in this review. The role of intracellular antioxidants such as glutathione (GSH), and drugs and nutriceutical agents promoting GSH synthesis, are discussed. The review also includes the early results of nutritional interventions based on a diet enriched with IMMUNOCALTM, a whey protein concentrate prepared in a proprietary manner.
Detection of Skin Perforators by Indocyanine Green Fluorescence Nearly Infrared Angiography (2008)

Azuma, Ryuichi M.D.; Morimoto, Yuji M.D., Ph.D.; Masumoto, Kazuma D.D.S., Ph.D.; Nambu, Masaki M.D.; Takikawa, Megumi M.D.; Yanagibayashi, Satoshi M.D.; Yamamoto, Naoto M.D., Ph.D.; Kikuchi, Makoto Ph.D.; Kiyosawa, Tomoharu M.D., Ph.D. Author Information