gebhart/patrepeval huggingface dataset:
14,15-Epoxyeicosatrienoic Acid Represents a Transferable Endothelium-Dependent Relaxing Factor in Bovine Coronary Arteries (2005)

Bradykinin causes arterial relaxation and hyperpolarization, which is mediated by a transferable endothelium-derived hyperpolarizing factor (EDHF). In coronary arteries, epoxyeicosatrienoic acids (EETs) are involved in the EDHF response. However, the role of EETs as transferable mediators of EDHF-dependent relaxation remains poorly defined. Two small bovine coronary arteries were cannulated and perfused in tandem in the presence of the nitric oxide synthase inhibitor, nitro-L-arginine (30 micromol/L), and the cyclooxygenase inhibitor, indomethacin (10 micromol/L). Luminal perfusate from donor arteries with intact endothelium perfused endothelium-denuded detector arteries. Detector arteries were constricted with U46619 and diameters were monitored. Bradykinin (10 nmol/L) added to detector arteries did not induce dilation (5+/-2%), whereas bradykinin addition to donor arteries dilated detector arteries by 26.5+/-7% (P<0.05). These dilations were blocked by donor artery endothelium removal and detector artery treatment with the EET-selective antagonist, 14,15-epoxyeicosa-5(Z)-monoenoic acid (14,15-EEZE; 10 micromol/L, -5+/-6%) but not 14,15-EEZE treatment of donor arteries (20+/-5%). 14,15-EET (0.1 to 10 micromol/L) added to detector arteries induced maximal dilations of 82+/-5% that were inhibited 50% by detector artery treatment with 14,15-EEZE (32+/-12%) but not donor artery treatment with 14,15-EEZE. Liquid chromatography-electrospray ionization mass spectrometry analysis verified the presence of 14,15-EET in the perfusate from an endothelium-intact but not denuded artery. These results show that bradykinin stimulates donor artery 14,15-EET release that dilates detector arteries. 14,15-EEZE blocked the donor artery, endothelium-dependent, bradykinin-induced relaxations, and attenuated relaxations to 14,15-EET. These results suggest that EETs are transferable EDHFs in coronary arteries.
Polarization effects on hard target calibration of lidar systems (1987)

The theory of hard target calibration of lidar backscatter data, including laboratory measurements of the pertinent target reflectance parameters, is extended to include the effects of polarization of the transmitted and received laser radiation. The bidirectional reflectance-distribution function model of reflectance is expanded to a 4 x 4 matrix allowing Mueller matrix and Stokes vector calculus to be employed. Target reflectance parameters for calibration of lidar backscatter data are derived for various lidar system polarization configurations from integrating sphere and monostatic reflectometer measurements. It is found that correct modeling of polarization effects is mandatory for accurate calibration of hard target reflectance parameters and, therefore, for accurate calibration of lidar backscatter data.
Structure and optical constants of electron beam deposited zinc nitride films (2009)

Zinc nitride (ZnN) films were prepared by electron beam evaporation technique. The effect of heat treatments on the structural and optical properties of these films were studied. The as-deposited films show amorphous structure and some peaks which are related to Zn3N2 and ZnO can be observed for annealed films. The study of the optical gap shows that these films have direct optical band gap about 3.2 eV at temperature 350 °C. At high temperature, the ZnN films become more opaque and resistive. Other optical parameters such as refractive index, extinction coefficient and dispersion parameters were investigated as a function of annealing temperature.
Supplementary Data 5 from Integrating Mathematical Modeling with High-Throughput Imaging Explains How Polyploid Populations Behave in Nutrient-Sparse Environments (2023)

&lt;p&gt;Simulation shown in Fig. 4E&lt;/p&gt;
Ultrafast pipelined arithmetic using quantum electronic devices (1994)

Negative differential resistance characteristics of several new quantum electronic devices have been used to design high-speed logic gates with the latching property. These latching gates form the basis of the ultrafast pipelined adder circuit described in this paper. The latching or memory feature of these circuits, which was previously considered to be a nuisance in the design of combinational circuits, is exploited to overcome the pipeline overheads of area and time. Simulation studies show that application of pipelining techniques can provide an effective throughput of one 32-bit addition every 1.6 ns using minimal hardware.
Spectacle correction versus no spectacles for prevention of strabismus in hyperopic children (2009)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: The primary objective of this review is to assess the safety and efficacy of spectacle correction of significant hyperopia in infants for the prevention of strabismus and accommodative esotropia.
Laser Printing of Plasmonic Nanosponges (2020)

Three-dimensional porous nanostructures made of noble metals represent novel class of nanomaterials promising for nonlinear nanooptics and sensors. Such nanostructures are typically fabricated using either reproducible yet time-consuming and costly multi-step lithography protocols or less reproducible chemical synthesis that involve liquid processing with toxic compounds. Here, we combined scalable nanosecond-laser ablation with advanced engineering of the chemical composition of thin substrate-supported Au films to produce nanobumps containing multiple nanopores inside. Most of the nanopores hidden beneath the nanobump surface can be further uncapped using gentle etching of the nanobumps by an Ar-ion beam to form functional 3D plasmonic nanosponges. The nanopores 10-150 nm in diameter were found to appear via laser-induced explosive evaporation/boiling and coalescence of the randomly arranged nucleation sites formed by nitrogen-rich areas of the Au films. Density of the nanopores can be controlled by the amount of the nitrogen in the Au films regulated in the process of their magnetron sputtering assisted with nitrogen-containing discharge gas.
The mass spectrometric [M C2H4O]+ process in cyclic ketones. I—the nature of the C2H4O losss in bicyclo[3.3.1]nonan‐2‐one and 3‐one (1976)

Abstract Although the loss of a C 2 H 4 O molecule from the molecular ions of the isomeric bicyclo[3.3.1]nonan‐2‐ and 3‐ones gives rise to the base peak at m/e 94 in both spectra, deuterium labelling results show that the processes leading to this ion are markedly different in the two cases. While the 2‐one follows essentially (&gt;80%) the same [M  C 2 H 4 O]+ fragmentation pathway described for other 2‐alkylcyclohexanones, the 3‐one exhibits a more complex decomposition pathway in which one α‐hydrogen is transferred away from the departing C 2 unit and three hydrogen atoms are subsequently rearranged to the eliminated C 2 H 4 O molecule. Similar competing fragmentation schemes have been invoked to explain deuterium labelling results in cycloheptanone, 2‐methylcycloheptanone and cyclooctanone.
Estimating signal phase and timing for traffic actuated intersections based on low frequency Floating Car Data (2016)

The objective of this paper is the application and statistical analysis of a methodology that allows the estimation of Signal Phase and Timing (SPaT) information like cycle length and green time intervals for time-dependent fixed-time controlled or traffic actuated intersections based on low-frequency and sparse vehicular probe data, so called Floating Car Data (FCD). To infer SPaT, the applied approach exploits the effects of periodic signal control, which will occur typically in case of traffic actuated signals with high saturation levels (e.g. in peak hours) or on fixed-time controlled intersections. The paper summarizes the fundamental concepts of cycle length estimation, as well as data filtering, needed to achieve robust and reliable signal timing estimates. To prove the estimation concept and to ensure the capability of a signal timing forecast based on ex ante estimates, a micro simulation is carried out, which supplies the signal timing estimation process with simulated FCD. The simulation model takes data sparsity, low-frequency (i.e. 15 sec. sampling interval) and erroneous vehicle positions into account. Finally, a statistical analysis compares inferred estimates against simulated ground truth.
Assessment of Efficiency and Sustainability in a Chemical Industry Using Goal Programming and AHP (2015)

This paper proposes a methodology for continuous assessment and improvement of the efficiency and sustainability in a Chemical Industry. This segment was chosen due to its importance both in the international (sixth largest worldwide revenues) and in Brazilian economic scenario (fourth segment in importance in the formation of industrial GDP). An exploratory analysis was performed by applying nonparametric techniques to measure and compare the efficiency and sustainability in a fictitious chemical production plant. The analyzed variables were identified and it was defined the importance (weight) of each of these by using the AHP (Analytic Hierarchy Process) method. It was defined a standard to be used as a benchmark and it was identified the implemented actions (projects) to achieve the proposed targets, using the technique of Goal Programming. The variables were defined considering sustainability and efficiency performance indicators. For sustainability were used as reference the standards defined in “Responsible Care®” program and the efficiency performance indicators were chosen considering some key items used by the market to assess efficiency of a production plant.
Absorption based UV-sensors for combustion processes (2002)

The recent progress in the areas of external cavity diode lasers, nonlinear optics and fiber amplification enable new optical sensors based on absorption spectroscopy in the UV range. Since transitions between electronic excited states are utilized, these sensors potentially offer higher sensitivity than comparable infra-red absorption sensors. Our work on OH and NO sensors is discussed.
Real-case application of mycorrhizal inoculums on Capsicum annuum L. var. longum cv. Szegedi and Kalocsai (2013)

The aim of this study was to test the use of commercially available arbuscular mycorrhiza (AM) inoculant Symbivit, a mixture of six species of Glomus spp., in spice pepper field cultivation. The inoculants containing arbuscular mycorrhizal fungi (AMF) was able to establish a symbiosis in the rhizosphere of pepper plants and mycorrhizal inoculation increased fresh and dry weights of shoots of spice pepper cv. Szegedi and only fresh weight of Kalocsai type. There were no significant differences in the root weights due to treatment only in fresh weight of Kalocsai pepper type. Treated plants of both variants exhibited an increase in cumulative crop production compared with control non-treated plants and the growth response of pepper was higher for var. Szegedi than var. Kalocsai. Mycorrhizal inoculation had a great positive effect on external hyphal length of AMF also showing differences in that between Kalocsai and Szegedi variants. The root colonization showed seasonality by treated and non-treated plants. The lowest degree of colonization was observed in June in general and colonization percent increased during vegetative development and there was a slight decrease at harvesting. In conclusion, it can be stated that inoculation with Symbivit containing mycorrhizal fungi could be an integral part of spice pepper production.
The local binary pattern approach to texture analysis — extensions and applications (2003)

This thesis presents extensions to the local binary pattern (LBP) texture analysis operator. The operator is defined as a gray-scale invariant texture measure, derived from a general definition of texture in a local neighborhood. It is made invariant against the rotation of the image domain, and supplemented with a rotation invariant measure of local contrast. The LBP is proposed as a unifying texture model that describes the formation of a texture with micro-textons and their statistical placement rules. The basic LBP is extended to facilitate the analysis of textures with multiple scales by combining neighborhoods with different sizes. The possible instability in sparse sampling is addressed with Gaussian low-pass filtering, which seems to be somewhat helpful. Cellular automata are used as texture features, presumably for the first time ever. With a straightforward inversion algorithm, arbitrarily large binary neighborhoods are encoded with an eight-bit cellular automaton rule, resulting in a very compact multi-scale texture descriptor. The performance of the new operator is shown in an experiment involving textures with multiple spatial scales. An opponent-color version of the LBP is introduced and applied to color textures. Good results are obtained in static illumination conditions. An empirical study with different color and texture measures however shows that color and texture should be treated separately. A number of different applications of the LBP operator are presented, emphasizing real-time issues. A very fast software implementation of the operator is introduced, and different ways of speeding up classification are evaluated. The operator is successfully applied to industrial visual inspection applications and to image retrieval.
Basement membrane type IV collagen degradation: evidence for the involvement of a proteolytic cascade independent of metalloproteinases. (1990)

Current hypotheses suggest that both the plasmin system and metalloproteinases are involved in tumor invasion of basement membrane. In this study, we demonstrate that plasmin can directly degrade native and denatured type IV collagen in solution as well as in tissue sections. Tumor cell lines secreted plasminogen activators into culture supernatants that activated exogenous plasminogen to degrade type IV collagen in zymograms and to remove collagen IV immunoreactivity from tissue sections. Inhibition of metalloproteinase activity in culture supernatants by EDTA did not interfere with plasminogen-mediated type IV collagen degradation. We propose that tumor cells possess a mechanism for the degradation of basement membrane type IV collagen, independent of metalloproteinases but dependent on plasminogen conversion to plasmin.
Roughness criteria and drag penalties for bands of distributed roughness on two slender wings at supersonic speeds (1963)

The variation of zero-lift drag coefficient with Reynolds number is used to determine the effectiveness of bands of distributed roughness on two slender wings at supersonic speeds.
Results show that the roughness height required to ensure fully turbulent flow up to the position of roughness increases rapidly with Mach number (M = 1·4 to 2·0) and that the roughness drag penalties may be significant.
Wing planform and camber both influence roughness effectiveness.
ChemInform Abstract: A NEW ROUTE TO 1,8‐DIPHENYLCYCLOOCTATETRAENE (1983)

Abstract Die photokatalysierte Addition von Tolan (II) an das Endion (I) führt zum polycyclischen Cyclobuten‐Derivat (III), das thermisch in das bicyclische Dion (V) und Anthracen (IV) gespalten wird.
Transient Kinetic Analysis of Hydrogen Sulfide Oxidation Catalyzed by Human Sulfide Quinone Oxidoreductase (2015)

The first step in the mitochondrial sulfide oxidation pathway is catalyzed by sulfide quinone oxidoreductase (SQR), which belongs to the family of flavoprotein disulfide oxidoreductases. During the catalytic cycle, the flavin cofactor is intermittently reduced by sulfide and oxidized by ubiquinone, linking H2S oxidation to the electron transfer chain and to energy metabolism. Human SQR can use multiple thiophilic acceptors, including sulfide, sulfite, and glutathione, to form as products, hydrodisulfide, thiosulfate, and glutathione persulfide, respectively. In this study, we have used transient kinetics to examine the mechanism of the flavin reductive half-reaction and have determined the redox potential of the bound flavin to be -123 ± 7 mV. We observe formation of an unusually intense charge-transfer (CT) complex when the enzyme is exposed to sulfide and unexpectedly, when it is exposed to sulfite. In the canonical reaction, sulfide serves as the sulfur donor and sulfite serves as the acceptor, forming thiosulfate. We show that thiosulfate is also formed when sulfide is added to the sulfite-induced CT intermediate, representing a new mechanism for thiosulfate formation. The CT complex is formed at a kinetically competent rate by reaction with sulfide but not with sulfite. Our study indicates that sulfide addition to the active site disulfide is preferred under normal turnover conditions. However, under pathological conditions when sulfite concentrations are high, sulfite could compete with sulfide for addition to the active site disulfide, leading to attenuation of SQR activity and to an alternate route for thiosulfate formation.
ChemInform Abstract: SODIUM PHOSPHATE SOLUBILITY AND PHASE RELATIONS BASIS FOR INVARIANT POINT CHEMISTRY CONTROL (1975)

Abstract Behandelt werden die Löslichkeit und die Phasenbeziehungen im System N 2 O ‐ P 2 O 5 ‐ H 2 O bei 300°C und einem Molverhältnis Na/PO4 zwischen 1,6 und 2,4.
Model Predictive Direct Power Control of Doubly Fed Induction Generator with Dead-Time Compensation (2017)

The paper presents the control of a doubly fed induction generator connected with a three-level neutral point clamped inverter with compensation of dead-time effects. The principle of the proposed control scheme is to use the dynamical model to compute predictions of the future values of the stator flux, rotor current and DC-link capacitor voltages for all possible configurations of voltage vectors. However, the dead-time to avoid the short circuit in the inverter also causes the modeling errors. Thus, by taking into account the dead-time in the model, it is possible compensate the dead-time effect of the switching devices. The active and reactive powers can be estimated based on the stator flux and the rotor current. The cost function considers the error between the active, reactive powers and their references, balance the DC-link capacitor voltage and reduce the switching frequency and common-mode voltage. The optimal switching state that minimizes the cost function is selected and applied to the inverter. The simulation results were carried out with Matlab under different conditions of wind speed and verifying the effectiveness of the proposed method.
Synthesis of 1,2,3,4-tetrahydro-1,1,2,3,3,4,4-heptamethyl-6,7-dimethoxyisoquinoline and related compounds as potential hypotensive agents (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 1,2,3,4-tetrahydro-1,1,2,3,3,4,4-heptamethyl-6,7-dimethoxyisoquinoline and related compounds as potential hypotensive agentsJacob Finkelstein, Elliot Chiang, and Arnold BrossiCite this: J. Med. Chem. 1971, 14, 7, 584–588Publication Date (Print):July 1, 1971Publication History Published online1 May 2002Published inissue 1 July 1971https://pubs.acs.org/doi/10.1021/jm00289a007https://doi.org/10.1021/jm00289a007research-articleACS PublicationsRequest reuse permissionsArticle Views87Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Calcitonin gene-related peptide promotes angiogenesis via AMP-activated protein kinase (2010)

Ischemia induces angiogenesis as a compensatory response. Although ischemia is known to causes synthesis and release of calcitonin gene-related peptide (CGRP), it is not clear whether CGRP regulates angiogenesis under ischemia and how does it function. Thus we investigated the role of CGRP in angiogenesis and the involved mechanisms. We found that CGRP level was increased in the rat hindlimb ischemic tissue. The expression of exogenous CGRP by adenovirus vectors enhanced blood flow recovery and increased capillary density in ischemic hindlimbs. In vitro, CGRP promoted human umbilical vein endothelial cell (HUVEC) tube formation and migration. Further more, CGRP activated AMP-activated protein kinase (AMPK) both in vivo and in vitro, and pharmacological inhibition of CGRP and cAMP attenuated the CGRP-activated AMPK in vitro. CGRP also induced endothelial nitric oxide synthase (eNOS) phosphorylation in HUVECs at Ser1177 and Ser633 in a time-dependent manner, and such effects were abolished by AMPK inhibitor Compound C. As well, Compound C blocked CGRP-enhanced HUVEC tube formation and migration. These findings indicate that CGRP promotes angiogenesis by activating the AMPK-eNOS pathway in endothelial cells.
Site-Selective Growth of Crystalline Ceria with Oxygen Vacancies on Gold Nanocrystals for Near-Infrared Nitrogen Photofixation (2019)

Site-selective growth of crystalline semiconductors on gold nanocrystals remains a great challenge because of the difficult control of both nucleation and growth dynamics as well as the easy agglomeration and deformation of gold nanocrystals at high temperatures of 400-1000 °C. Here we report a facile wet-chemistry route for the selective growth of crystalline ceria at the ends of gold nanorods (Au NRs) in the presence of a small amount of bifunctional K<sub>2</sub>PtCl<sub>4</sub>. Due to the smaller steric hindrance at the ends than at the side surface, K<sub>2</sub>PtCl<sub>4</sub> may preferentially adsorb at the ends of Au NRs, triggering the autoredox reaction with the ceria precursor to obtain crystalline CeO<sub>2</sub> at the ends. Notably, the surface of grown ceria is rich in oxygen vacancies (OVs) that facilitate the adsorption and activation of N<sub>2</sub> molecules. The unique structure, the plasmon-induced hot carriers and the OVs make the obtained Au/end-CeO<sub>2</sub> an excellent catalyst for nitrogen photofixation under near-infrared (NIR) illumination.