gebhart/patrepeval huggingface dataset:
The Use of Antisera to the Human Herpesvirus 6 Major Capsid Protein to Determine the Effect of Antiviral Inhibitors on Virus Gene Expression (1990)

We have recently described the production of antisera which react with the human herpesvirus 6 (HHV-6) major capsid protein (MCP). We describe here the use of these specific antisera to characterize the kinetics of expression of the HHV-6 MCP and demonstrate that it is a late virus protein, expressed after DNA replication. We have used the expression of this protein as a measure of the efficacy of the antiviral nucleoside analogues 9-(2-hydroxyethoxymethyl)guanine (ACV) and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) upon HHV-6 replication and have determined 50% inhibitory concentrations to be 150 μm and 2 μm, respectively.
Graded Stress Radiography in Acute Injury to the Lateral Ligaments of the Ankle (1990)

The diagnostic accuracy of graded stress radiography in 26 patients with acute injury to the lateral ankle ligaments has been compared with findings at arthrography and surgery. Measuring talar tilt angles and anterior talar displacement over a range of pressures applied to the distal tibia using a commercially available stress device allows diagnostic distinction between isolated anterior talofibular ligament injury and a combined lesion that involves the calcaneofibular ligament. The results compare well with arthrographic and surgical findings.
Transverse Myelitis (2010)

An otherwise healthy 28-year-old woman presents with progressive weakness for the past 3 days, numbness below her breasts, and urinary urgency. Neck flexion triggers an electrical sensation that radiates to the coccyx. Examination reveals moderate paraparesis with hyperreflexia, a left extensor plantar response, impaired vibratory and proprioceptive sensation, and a sensory level at T6. Magnetic resonance imaging reveals a lower cervical cord lesion that enhances after gadolinium administration, a finding consistent with transverse myelitis. How should she be further evaluated and treated?
Exploring the Effect of Particle Concentration and Irradiation Time in the Synthesis of Barium Strontium Titanate (BST) Ba(1-X)SrxTiO3 (X:0-1) Nanoparticles by High Power Ultrasonic Irradiation (2016)

Barium strontium titanate (BST) or Ba1-xSrxTiO3 with x=0-1 possesses superior dielectric
properties, which are widely used in many applications like in communication technology,
electronic instrumentations, and various electrical devices. In this paper, the characterization of
the particle and crystallite size of Ba1-xSrxTiO3 (x: 0; 0.3; 0.7) is described. A two-step
refinement commenced: first by mechanical milling, and then a further refinement under
ultrasonic irradiation in a high power sonicator was applied to Ba1-xSrxTiO3 (x: 0; 0.3; 0.7)
particles. The crystalline powders were obtained through mechanically alloyed standard
research grade BaCO3, TiO2, and SrCO3 precursors in a planetary ball mill.The powders were
first found heavily deformed after 60 hours of milling and then went through a sintering process
at 1200°C for 4 hours to form multicrystallite particles. The presence of a single phase in the
three samples was solidly confirmed in their respective X-ray diffraction (XRD) patterns. The
changes of multicrystallite particles into monocrystallite particles were obtained only after
crystalline powders were irradiated ultrasonically in a high power sonicator. The processing
variable during ultrasonic irradiation was limited to the duration time of irradiation and particle
concentration in the exposed media. It is shown that the average sizes of BST particles at x=0;
0.3; 0.7 before ultrasonic irradiation were 353, 348, and 385 nm, respectively. These respective
sizes decreased drastically to 52, 35, and 49 nm, respectively, after 12 hours of ultrasonic
irradiation. These particle sizes are almost identical with that of their crystallite size. Hence, the
synthesis of monocrystallite particles has been achieved. As the particle concentration of media
takes effect, it is shown that an exposed media with a higher particle concentration tends to
form multicrystallite particles.
Keywords: Barium strontium titanate; Mechanical alloying; Nanoparticle; Particle size;
Ultrasonic irradiation
Low-cost through silicon vias (TSVs) with wire-bonded metal cores and low capacitive substrate-coupling (2010)

The three-dimensional (3D) integration of electronics and/or MEMS-based transducers is an emerging technology that vertically interconnects stacked dies using through silicon vias (TSVs). They enable the realization of devices with shorter signal lengths, smaller packages and lower parasitic capacitances, which can result in higher performance and lower costs. This paper presents a novel low-cost fabrication technique for metal-filled TSVs using bonded gold-wires as conductive path. In this concept the wires are surrounded by polymer, which acts both as an electrical insulator causing low capacitive coupling towards the substrate and as a buffer for thermo-mechanical stress.
Compressive light field imaging with weighted random projections (2011)

Traditional light field imagers do not exploit the inherent spatio-angular correlations in light field of natural scenes towards reducing the number of measurements and minimizing the spatio-angular resolution trade-off. Here we describe a <i>compressive </i>light field imager that utilizes the prior knowledge of sparsity/compressibility along the spatial dimension of the light field to make compressive measurements. The reconstruction performance is analyzed for three choices of measurement bases: wavelet, random, and weighted random using a simulation study. We find that the weighted random bases outperforms both the <i>coherent </i>wavelet basis and the <i>incoherent</i> random basis on a light field data set. Specifically, the simulation study shows that the weighted random basis achieves 44% to 50% lower reconstruction error compared to wavelet and random bases for a compression ratio of three.
The Bovine Basic Pancreatic Trypsin Inhibitor (Kunitz Inhibitor): A Milestone Protein (2003)

The pancreatic Kunitz inhibitor, also known as aprotinin, bovine basic pancreatic trypsin inhibitor (BPTI), and trypsin-kallikrein inhibitor, is one of the most extensively studied globular proteins. It has proved to be a particularly attractive and powerful tool for studying protein conformation as well as molecular bases of protein/protein interaction(s) and (macro)molecular recognition. BPTI has a relatively broad specificity, inhibiting trypsin- as well as chymotrypsin- and elastase-like serine (pro)enzymes endowed with very different primary specificity. BPTI reacts rapidly with serine proteases to form stable complexes, but the enzyme: inhibitor complex formation may involve several intermediates corresponding to discrete reaction steps. Moreover, BPTI inhibits the nitric oxide synthase type-I and -II action and impairs K+ transport by Ca2+-activated K+ channels. Clinically, the use of BPTI in selected surgical interventions, such as cardiopulmonary surgery and orthotopic liver transplantation, is advised, as it significantly reduces hemorrhagic complications and thus blood-transfusion requirements. Here, the structural, inhibition, and bio-medical aspects of BPTI are reported.
Time-Varying Filter Banks with Low Delay for Audio Coding (1998)

A design method and filter structure for fast modulated low delay filter banks is presented. The system delay can be pre-specified independent of the filter length. Perfect reconstruction is structurally guaranteed. It is shown how to make this structure time-varying, which includes switching the number of bands, while maintaining perfect reconstruction. Low delay filter banks, besides having the advantage of a low system delay, can reduce pre-echoes in coding applications. Design examples are shown, including a low delay filter bank which can be switched between 1024 and 128 bands. Results of listening tests with the MPEG-AAC coder show that they indeed can be used to reduce pre-echoes in non-stationary signals like castanets.
Perforator Based Reverse Radial Artery Forearm Flap (Prraff): Anatomical Studies and Clinical Applications (1995)

Summary A perforator based reverse radial artery forearm flap has been used from the volar and radial aspect of the distal forearm for coverage of raw areas near the wrist, distal forearm and hand in six cases. This was preceded by an anatomical study in ten cadaveric limbs concentrating on the position and size of the subcutaneous perforators from the radial artery in the distal half of the forearm. It revealed that there are constant perforators from the radial artery situated approximately 1, 3 and 7 cm. proximal to the radial styloid process and flaps could be raised based on the 1 cm and 3 cm perforators. We found this to be a reliable flap to cover small raw areas near the wrist and the proximal part of the hand, the main advantage being not sacrificing the main trunk of the radial artery.
Enantioselective synthesis of non-natural amino acids using phenylalanine dehydrogenases modified by site-directed mutagenesis (2004)

The substrate scope of three mutants of phenylalanine dehydrogenase as biocatalysts for the transformation of a series of 2-oxo acids, structurally related to phenylpyruvic acid, to the analogous alpha-amino acids, non-natural analogues of phenylalanine, has been investigated. The mutant enzymes are more tolerant than the wild type enzyme of the non-natural substrates, especially those with substituents at the 4-position on the phenyl ring. Excellent enantiocontrol resulted in all cases.
Observation géographiques et floristiques sur la presqu’île de Leucate (1999)

The Leucate peninsula and the northern edge of the Etang de Leucate have undergone considerable landscape changes in recent years. The paper describes landscapes changes and floristique dynamic on the peninsula of Leucate in Mediterranean France. Special focus is given to the dynamic of thermomediterranean plant species in the 1990. Describes also the presence of (subspontanous) Chamaerops humilis in the Leucate area (incl. Map of presence in the 1990). La péninsule de Leucate et la bordure nord de l'étang de Leucate ont subi des changements paysagers considérables au cours des dernières années. L'article décrit les changements paysagers et la dynamique floristique sur la péninsule de Leucate en France méditerranéenne. Une attention particulière est accordée à la dynamique des espèces végétales thermoméditerranéennes dans les années 1990. Il décrit également la présence de Chamaerops humilis (subspontané) dans la région de Leucate (y compris la carte de présence en 1990).
Time-domain approach for stochastic cooling study (2015)

In this paper the time domain algorithm is described. The beam dynamics under influence of stochastic cooling forces is studied by a particle-by-particle and turn-by-turn treatment in the time-domain. This treatment escapes the involvement of complicated, changing frequency spectra, which anyhow are likely to be incomplete by considering the Fokker–Planck equation and its solution. Using the proposed method, a special computer code has been developed to calculate beam cooling in the time domain within reasonable computing time.
Synthesis, Characterization and Investigation of Different Properties of Three Novel Thiourea‐Based Non‐ionic Surfactants (2014)

Abstract Three novel thiourea‐based non‐ionic surfactants, 3‐decanoyl‐1,1‐diphenylthiourea, 3‐dodecanoyl‐1,1‐diphenylthiourea and 1,1‐diphenyl‐3‐tetradecanoylthiourea were synthesized from carbonyl chlorides, potassium thiocyanate and amines in high yield. The synthesized compounds were characterized by different techniques like 1 H NMR, 13 C NMR, FTIR and UV‐Visible spectrophotometry. These surfactants are soluble in nonpolar and polar organic solvents and resist solubility in water due to the presence of thiourea group. Electronic absorption spectroscopy was used to evaluate their critical micelle concentration (CMC) in different solvents. The CMC was found to decrease with increase in hydrophobic carbon chain length as expected. Moreover, the effect of pH on their spectral transition was investigated and the two peaks were found to merge in highly alkaline conditions.
Meta-analysis of Treatment Outcomes of Non-saccular Aneurysms in the Posterior Circulation by Flow Diverters (2018)

Background Non-saccular aneurysms of the posterior circulation are uncommon but highly dangerous lesions. Flow diverter stents have been demonstrated to be effective treatments of various anterior circulation aneurysms, particularly large and giant proximal internal carotid artery aneurysms. However, evidence regarding the treatment of non-saccular posterior circulation aneurysms with flow diverters is lacking.
Application of Photoisomerizable Antigenic Monolayer Electrodes as Reversible Amperometric Immunosensors (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplication of Photoisomerizable Antigenic Monolayer Electrodes as Reversible Amperometric ImmunosensorsItamar Willner, Ron Blonder, and Arie DaganCite this: J. Am. Chem. Soc. 1994, 116, 20, 9365–9366Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/ja00099a078https://doi.org/10.1021/ja00099a078research-articleACS PublicationsRequest reuse permissionsArticle Views319Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dendritic Cytoskeletal Architecture Is Modulated by Combinatorial Transcriptional Regulation in Drosophila melanogaster (2017)

Transcription factors (TFs) have emerged as essential cell autonomous mediators of subtype specific dendritogenesis; however, the downstream effectors of these TFs remain largely unknown, as are the cellular events that TFs control to direct morphological change. As dendritic morphology is largely dictated by the organization of the actin and microtubule (MT) cytoskeletons, elucidating TF-mediated cytoskeletal regulatory programs is key to understanding molecular control of diverse dendritic morphologies. Previous studies in <i>Drosophila melanogaster</i> have demonstrated that the conserved TFs Cut and Knot exert combinatorial control over aspects of dendritic cytoskeleton development, promoting actin and MT-based arbor morphology, respectively. To investigate transcriptional targets of Cut and/or Knot regulation, we conducted systematic neurogenomic studies, coupled with <i>in vivo</i> genetic screens utilizing multi-fluor cytoskeletal and membrane marker reporters. These analyses identified a host of putative Cut and/or Knot effector molecules, and a subset of these putative TF targets converge on modulating dendritic cytoskeletal architecture, which are grouped into three major phenotypic categories, based upon neuromorphometric analyses: complexity enhancer, complexity shifter, and complexity suppressor. Complexity enhancer genes normally function to promote higher order dendritic growth and branching with variable effects on MT stabilization and F-actin organization, whereas complexity shifter and complexity suppressor genes normally function in regulating proximal-distal branching distribution or in restricting higher order branching complexity, respectively, with spatially restricted impacts on the dendritic cytoskeleton. Collectively, we implicate novel genes and cellular programs by which TFs distinctly and combinatorially govern dendritogenesis via cytoskeletal modulation.
Optomechanics with hybrid carbon nanotube resonators (2017)

In this paper we report our first experimental results towards the establishment of a novel nanooptomechanical platform consisting of a hybrid, carbon nanotube-based mechanical resonator. We have been able to optically measure and actively control these resonators demonstrating a record force sensitivity at ambient temperature. Finally, we have observed optomechanically-induced dynamical effects and optomechanical enhancement of the force sensitivity in a cavity-free scheme.
Entropy Production Minimization as Design Principle for Membrane Systems: Comparing Equipartition Results to Numerical Optima (2017)

Entropy production minimization procedures presented in literature show that under different assumptions the optimal solution might be characterized by different thermodynamic quantities being constant. These constant quantities might be the local entropy production, the thermodynamic driving forces, the thermodynamic speed, or the thermodynamic length. After presenting the assumptions made in the different derivations, we use the results as design principles to reduce entropy production in a membrane unit for CO2 separation from natural gas, and we compare them to the numerically determined optimum. For a continuous process, we consider the equipartition of forces (EoF), the equipartition of entropy production (EoEP), and the equal thermodynamic speed (ETS) results. When we can independently control all driving forces, the numerical optimum and EoEP coincide. Even though EoF and ETS differ from the optimum, they approximate it well. When the transport coefficients are constant, EoF follows from EoEP. If the optimization was carried out with fixed number of relaxations instead of fixed length of the membrane unit, then the thermodynamic speed would be constant in the optimal case. When the thermodynamic driving forces cannot be controlled independently, neither of the equipartition results characterizes the optimal solution. However, EoEP and ETS approximate it well. Since EoEP and ETS give good approximations of (or coincide with) the numerical optimum independently of the type of control, they can be used as design principles to reduce entropy production in membrane systems. However, using an equipartition result as a design principle will generally not give one and only one solution, and some equipartitioned designs may be far from the optimum. For a discrete process, we considered the EoEP and the equal thermodynamic length (ETL) results. In this case, EoEP gives the best approximation of the optimum. Since the process is not an equilibration process, ETL does not coincide with the optimum, but it still approximates it well.
Differential Effects of T-Cell Activation on Gastric and Small Bowel Permeability in Alcohol-Consuming Mice (2002)

Background A number of variables influence the effect(s) of alcohol on distinct segments of the intestine. In these studies, we examined the effect of T-cell activation on gastric and small bowel permeability in alcohol-fed mice. Methods Gastric permeability was assessed using sucrose absorption, whereas small bowel permeability was followed using the ratio of lactulose to mannitol absorption and inulin absorption. T cells were activated by injecting antigen OVA323–339 into DO11.10 T-cell receptor transgenic mice. Results T-cell activation increased gastric and small bowel permeability through a pathway mediated by interferon-γ and tumor necrosis factor. In mice that were fed a liquid diet that contained 30% ethanol-derived calories for 2 weeks, T-cell activation increased gastric permeability to levels greater than that observed in solid diet or pair-fed, liquid control diet. By comparison, changes in small bowel permeability induced by T-cell activation were abrogated in alcohol-fed mice. Analysis of intestinal cytokine mRNA levels (interferon-γ and tumor necrosis factor) indicated that relevant mucosal T-cell function was preserved in alcohol-fed mice Conclusions Overall, these data suggest that alcohol potentiates the effects of T-cell activation on gastric permeability, at the same time blunting effects on small bowel permeability
REASONS FOR fflGHER EXIT CARBON OXIDES BY USING NEW METHANATION CATALYST (2004)

This article analyses the reasons for higher exit carbon oxides contents from the methanator when new methanation catalyst was put into operation. The result shows that the catalyst was not reduced completely. Measuring basis for the characterization of reduction degree of methanation catalyst is suggested, and it is proposed that the catalyst not completely reduced should be reduced on-line once more.
Circulating MicroRNA as Biomarkers: An Update in Prostate Cancer. (2011)

Prostate cancer (PCa) is the most common non-skin cancer among men. Currently available diagnostic tests for PCa are inadequate in terms of low specificity and poor sensitivity. microRNAs offer a hope to overcome these drawbacks by virtue of their cancer specific expression and high stability. They can readily be detected and quantified in frozen and as well as formalin-fixed paraffin-embedded tissues. Observation of circulating miRNA in serum/plasma samples and other body fluids holds a promise to quickly move from research and provide a biomolecule of clinical relevance and an improvement over presently available biomarkers. This review highlights the potential role of circulating miRNAs as molecular markers for cancer and as targets for therapeutic manipulation. Further, this review summarizes the current understanding of various circulating miRNA with respect to prostate cancer. To conclude, circulating miRNAs are an active area of current investigation and holds promise to serve a wide range of clinical applications and unwrap a new era in cancer diagnosis and therapeutics.
Shape and dimensions of cardiac chambers: importance of CT section thickness and orientation. (1985)

Three-dimensional (3D) computed tomography (CT) scan data were used to quantitate the geometry of all heart chambers. The Dynamic Spatial Reconstructor (DSR) was used to scan dogs with in situ casts of the cardiac chambers. Chamber volumes estimated from DSR images were accurate within 5% of water displacement volume measurements of the actual casts for chambers greater than 11 ml and within 10% of water displacement volumes for chambers less than 11 ml. Anatomic features of the actual cast correlated closely with anatomy visible in computer-generated surface images of the 3D DSR image data. The important effect of reconstructed section thickness and orientation on the fidelity of 3D cardiac geometry is demonstrated.
Tunable Laser Diodes (1999)

Fundamental laser diode characeristics single-mode laser diodes basic concepts for tunable laser diodes continuously tunable single-mode laser diodes linewidth broadening discontinuously tunable laser diodes related components.