gebhart/patrepeval huggingface dataset:
Genome-Wide Association Study of Absolute QRS Voltage Identifies Common Variants of TBX3 as Genetic Determinants of Left Ventricular Mass in a Healthy Japanese Population (2016)

Left ventricular hypertrophy (LVH) represents a common final pathway leading to heart failure. We have searched for genetic determinants of left ventricular (LV) mass using values for absolute electrocardiographic QRS voltage in a healthy Japanese population. After adjusting for covariates, the corrected S and R wave voltages in leads V1 and V5 from 2,994 healthy volunteers in the Japan Pharmacogenomics Data Science Consortium (JPDSC) database were subjected to a genome-wide association study. Potential associations were validated by an in silico replication study using an independent Japanese population obtained from the Nagahama Prospective Genome Cohort for Comprehensive Human Bioscience. We identified a novel association between the lead V5, R wave voltage in Japanese individuals and SNP rs7301743[G], which maps near the gene encoding T-box transcription factor Tbx3. Meta-analysis of two independent Japanese datasets demonstrated a marginally significant association of SNP rs7301743 in TBX3|MED13L with a 0.071 mV (95% CI, 0.038-0.11 mV) shorter R wave amplitude in the V5 lead per minor allele copy (P = 7.635 x 10(-8)). The transcriptional repressor, TBX3, is proposed to suppress the development of working ventricular myocardium. Our findings suggest that genetic variation of Tbx3 is associated with LV mass in a healthy Japanese population.
Standardization of transfusion practice in organ donors using the Digital Intern, an electronic decision support algorithm (2017)

The DI provides a more standardization transfusion practice in organ donors and reduces blood use without compromising transplantable organs.
Controlled Exposure Study of Air Pollution and T-Wave Alternans in Volunteers without Cardiovascular Disease (2012)

In our study of 17 volunteers who had no preexisting cardiovascular disease, we did not observe significant changes in T-wave alternans after 2-hr exposures to CAP, O3, or combined CAP + O3. This finding, however, does not preclude the possibility of pollution-related effects on TWA at elevated heart rates, such as during exercise, or the possibility of delayed responses.
Local quantized extrema quinary pattern: a new descriptor for biomedical image indexing and retrieval (2017)

In this paper a new feature descriptor ‘local quantised extrema quinary pattern (LQEQryP)’ is proposed for biomedical image indexing and retrieval. The binary and non-binary codings such as local binary patterns (LBP), local ternary patterns (LTP) and local quinary patterns (LQP) encode the gray scale relationship between the centre pixel and its surrounding neighbours in two dimensional (2D) local region of an image, whereas the proposed method encodes the spatial relation between any pair of neighbours in a local region along the given directions (i.e. 0°, 45°, 90° and 135°) for a given centre pixel in an image. The novelty of the proposed method is it uses quinary pattern features from horizontal-vertical-diagonal-anti-diagonal (HVDA 7) structure of directional local extrema values of an image to encode more spatial structure information which lead to better retrieval. LQEQryP also provides a significant increase in discriminative power by allowing larger local pattern neighbourhoods. The experiments have been carried out for proving the worth of proposed algorithm on three different types of benchmark biomedical databases; (i) computed tomography (CT) scanned lung image databases named as LIDC-IDRI-CT and VIA/I–ELCAP-CT, (ii) brain magnetic resonance imaging (MRI) database named as OASIS-MRI. The results demonstrate the superiority of the proposed method in terms of average retrieval precision (ARP) and average retrieval rate (ARR) over state-of-the-art feature extraction techniques such as LBP, LTP and LQEP, etc.
Robust <tex>$\mathcal{H}_{\infty}$</tex> Pointing Error Control of Free Space Optical Communication Systems (2018)

This paper proposes a robust H∞ approach for free space optical (FSO) beam pointing error systems. First, a deterministic discrete-time model for pointing error loss due to misalignment is presented. This model considers detector aperture size and optical beam width. Then, the control problem that guarantees the stability of the closed-loop pointing error and the attenuation of the disturbance is investigated through a robust H∞ control framework. Finally, numerical simulations of the FSO link under the effect of a controlled weak turbulence condition are performed to demonstrate the feasibility of the proposed robust pointing error approach.
Small molecule pan-bcl-2 inhibitor AT-101 induces apoptosis in NSCLC by up-regulating noxa and enhances antitumor activity of docetaxel or targeted kinase inhibitors (2009)

e14591 Background: AT-101 is an orally active pan Bcl-2 inhibitor currently under clinical development in Phase II trials. We investigated the effect of AT-101 alone or in combination with chemotherapies or targeted kinase inhibitors in NSCLC both in vitro and in vivo. Methods: Growth inhibition was measured by WST assays. The CalculSyn method was used to assess drug interaction by calculating the Combination Index (CI) value. The ability of AT-101 to potentiate the anti-cancer effect of chemotherapies or kinase inhibitors was evaluated in xenograft models. Results: A panel of 11 NSCLC cell lines with overexpression of Bcl-2, Bcl- X L or Mcl-1 proteins was treated with AT-101, docetaxel, pemetrexed, erlotinib, sorafenib, sunitinib, rapamycin, as a single agent and in combination. AT-101 inhibited the growth with IC 50 at 3–9 uM. When treating cells simultaneously with both agents, AT-101 demonstrated strong synergy with those agents in A549 or H460 cells with CI values &lt; 1.0. Protein analysis results indicated that AT-101 caused apoptosis by a time- and dose-dependent induction of Noxa expression in those cells. The expression of Bcl- X L was not influenced by AT-101. Pro-Caspase-3 was reduced with increasing doses of AT-101. In vivo, combined treatment of AT-101 with docetaxel, erlotinib, or sorafenib synergistically suppressed subcutaneous NSCLC A549 cells tumor growth compared with treatment with either agent alone. The synergist effects with the ErbB1 inhibitor Erlotinib is associated with the overexpression of the target protein ErbB1 in those cells. Only combination therapy resulted in significant tumor growth delay and no significant toxicities were observed. Conclusions: Our results demonstrate that AT-101significantly enhances the anti-tumor activity of chemotherapy and targeted agents and may represent a promising new anticancer agent with a novel molecular mechanism. Molecular targeted therapy with AT-101 may improve the outcome of current chemotherapy for NSCLC with Bcl-2, Bcl-xL and/or Mcl-1 overexpression. [Table: see text]
TIER II Emission Reduction Strategies for US HSDI Diesels (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Cell-Trappable Quinoline-Derivatized Fluoresceins for Selective and Reversible Biological Zn(II) Detection (2010)

The synthesis and spectroscopic characterization of two new, cell-trappable fluorescent probes for Zn(II) are presented. These probes, 2-(4,5-bis(((6-(2-ethoxy-2-oxoethoxy)quinolin-8-yl)amino)methyl)-6-hydroxy-3-oxo-3H-8 xanthen-9-yl)benzoic acid (QZ2E) and 2,2'-((8,8'-(((9-(2-carboxyphenyl)-6-hydroxy-3-oxo-3H-xanthene-4,5-diyl)bis(methylene))bis(azanediyl))bis(quinoline-8,6-diyl))bis(oxy))diacetic acid (QZ2A), are poorly emissive in the off-state but exhibit dramatic increases in fluorescence upon Zn(II) binding (120 ± 10-fold for QZ2E, 30 ± 7-fold for QZ2A). This binding is selective for Zn(II) over other biologically relevant metal cations, toxic heavy metals, and most first-row transition metals and is of appropriate affinity (K(d1)(QZ2E) = 150 ± 100 μM, K(d2)(QZ2E) = 3.5 ± 0.1 mM, K(d1)(QZ2A) = 220 ± 30 μM, K(d2)(QZ2A) = 160 ± 80 μM, K(d3)(QZ2A) = 9 ± 6 μM) to reversibly bind Zn(II) at physiological levels. In live cells, QZ2E localizes to the Gogli apparatus where it can detect Zn(II). It is cell-membrane-permeable until cleavage of its ester groups by intracellular esterases produces QZ2A, a negatively charged acid form that cannot cross the cell membrane.
Scanning And Detection Of Static And Moving Pedestrians By Drivers With Hemianopia In A Simulator (2012)

PURPOSE: In our previous simulator study of drivers with hemianopia (Bowers et al., 2009), we reported large detection deficits for stationary pedestrians that appeared in the blind hemifield. Using a more realistic hazard, we are now evaluating detection of pedestrians that move on a collision course toward the car’s heading direction. We predicted that blindside detection rates would be higher for moving pedestrians (as they maintain an approximately constant eccentricity with respect to the car) than for static pedestrians (eccentricity of the pedestrian increases rapidly as the car approaches, thus moving the hazard further into the blind hemifield). In addition, we are evaluating the relationship between gaze behaviors and detection performance.
Killing of methicillin-resistant Staphylococcus aureus by low-power laser light (1995)

The purpose of this study was to determine whether a methicillin-resistant strain of Staphylococcus aureus (MRSA) could be sensitised by toluidine blue O (TBO) to killing by light from a low-power helium/neon (HeNe) laser. Suspensions containing c. 10(10) cfu of MRSA were irradiated with light from a 35 mW HeNe laser (energy dose: 0.5-2.1 J) in the presence of TBO (1.6-12.5 micrograms/ml) and the survivors were enumerated. The kills attained depended on both the light energy dose and concentration of TBO employed. A 4.47 log10 reduction in the viable count was achieved with a TBO concentration of 12.5 micrograms/ml and a light dose of 2.1 J (energy density 43 J/cm2). MRSA were susceptible to killing by the laser light within 30 s of exposure to the TBO. The results of this study have demonstrated that MRSA can be rapidly sensitised by TBO to killing by HeNe laser light and that killing depends on the light energy dose and sensitiser concentration.
Surveillance d'installations industrielles: démarche générale et conception de l'algorithmique (1996)

Ce rapport a pour but de présenter la démarche générale élaborée à l'IRISA en matière de surveillance d'installations industrielles pour la maintenance conditionnelle. Cette démarche permet, pour une large classe de modèles, la conception systématique des algorithmes nécessaires, à partir de la donnée de la structure du modèle adéquat pour le système surveillé. Nous rappelons les deux principaux exemples d'application qui illustrent sa pertinence. Puis nous décrivons les extensions en cours, concernant l'application d'une part aux modèles de type réseaux de neurones ou d'ondelettes, et d'autre part à des modèles dynamiques hybrides numérique/symbolique. Nous indiquons une organisation possible des logiciels correspondants et des commentaires sur les références citées. Puis nous décrivons les fondements théoriques des techniques présidant aux différentes étapes de la conception de l'algorithmique correspondante.
Femtosecond laser micromachining of fibre Bragg gratings for simultaneous measurement of temperature and concentration of liquids (2008)

This paper is concerned with micromachining of optical fibre Bragg gratings (FBGs) using a femtosecond pulsed laser. The purpose of this work is to increase the sensitivity of FBGs for simultaneous monitoring of the concentration of chemicals and biological liquids and their temperature. A Ti : sapphire regenerative amplifier was utilized to inscribe micro-grooves with widths of 16 and 22 νm in the cladding of the optical fibres. Due to the core-confined light propagation characteristics of FBGs, their sensitivity to the changes in the index of refraction of the surrounding medium is minimal. However, by creating micro-grooves in the cladding layer, the index of refraction of the surrounding medium becomes effective in the coupling of the propagating core modes. As the index of refraction of liquids depends on the composition and concentration, the FBG with micromachined cladding can provide enough sensitivity to be used in chemical sensing. The performance of the micromachined FBGs was investigated by immersing them in different liquid solutions of polyvinyl butyral (PVB) in ethanol and obtaining their thermal responses. Results showed that the optical response of the micromachined FBGs (i.e. red shift in Bragg wavelength) is different by up to 10% in PVB solutions in ethanol than in ethanol alone. The micromachined FBGs can be used to monitor the concentration as well as the temperature of a solution. © 2008 IOP Publishing Ltd.
Overview of NASA White Sands Test Facility Composite Overwrapped Pressure Vessel Testing (2006)

This viewgraph presentation examines the White Sands Test Facility testing of Composite overwrapped pressure vessel (COPV). A COPV is typically a metallic liner overwrapped with a fiber epoxy matrix. There is a weight advantage over the traditional all metal design. The presentation shows pictures of the facilities at White Sands, and then examines some of the testing performed. The tests include fluids compatibility, and Kevlar COPV. Data for the Kevlar tests are given, and an analysis is reviewed. There is also a comparison between Carbon COPVs and the Kevlar COPVs.
On the string averaging method for sparse common fixed‐point problems (2009)

We study the common fixed point problem for the class of directed operators. This class is important because many commonly used nonlinear operators in convex optimization belong to it. We propose a definition of sparseness of a family of operators and investigate a string-averaging algorithmic scheme that favorably handles the common fixed points problem when the family of operators is sparse. The convex feasibility problem is treated as a special case and a new subgradient projections algorithmic scheme is obtained.
Termite resistance of TMSAC or TMSAH added wood-inorganic composites prepared by the sol-gel process (2004)

Antimicrobial SiO2 wood-inorganic composites with 3-(trimethoxysilyl) propyl dimethyl octadecyl ammonium chloride (TMSAC) or 3-(trimethoxysilyl) propyl (carboxymethyl) decylmethyl ammonium hydroxide inner salt (TMSAH) were prepared by the sol-gel process. The obtained TMSAC-Si02 or TMSAH-Si02 composites were studied on their termite resistance to both Reticulitermes speratus (Kolbe) and Coptotermes formosanus Shiraki. Although TMSAC-Si02 composites could not attain the enhanced property in termite resistance, TMSAH-SiO2 only with at most 10% in weight percent gain revealed such a high termite resistance as the treated wood with boric acid which is well-known as a wood preservative against termites.
PAW22 Does cortical atrophy take place after basal ganglia damage in multiple system atrophy and progressive supranuclear palsy? (2010)

Magnetic resonance imaging (MRI) has the potential to aid characterise of disease progression in multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). <h3>Methods</h3> Six patients with probable MSA (mean age (years±SD) was 61±10.4) and 7 with PSP (64.7±5.9 years) according to NNIPPS criteria were prospectively recruited for MRI scanning at King9s College Hospital. Illness duration at baseline was 5.6±2 (MSA) and 3.72±2.6 (PSP), and at follow-up 8.29±1.7 and 6.58±2.7, respectively; assessment intervals were 2.6±0.2 (MSA) and 2.8±0.3. SIENA was used to estimate local and global brain volume change between MRI at each timepoint, by co-registering and segmenting the images and calculating displacement of the brain/nonbrain boundary. <h3>Results</h3> Annual global brain atrophy was 1.27±0.6% (MSA) and 1.5±0.7% (PSP). In PSP, localised grey matter atrophy was detected in left superior temporal gyrus, right parahippocampal gyrus, left nucleus dentate, left cerebellar tonsil and right semilunar cerebellum. In MSA, left superior, middle frontal gyrus and right frontopolar regions were affected. <h3>Discussion</h3> Progressive atrophy was found in frontal and temporal cortices in both disorders; the absence of change in striatum and pallidum may reflect already severely damage at baseline.
Sonochemical synthesis of new materials (1999)

High-intensity ultrasound has found new applications in the synthesis of unusual inorganic materials. The chemical effects of ultrasound originate from acoustic cavitation, which produces local transient conditions of ∼5000 K, ∼500 atm, with heating and cooling rates that exceed 1×1010 K/s. In cold liquids, ultrasound is able to drive reactions that normally occur only under extreme conditions. Examples include intercalation, activation of liquid–solid reactions, and synthesis of amorphous and nanophase materials. The sonochemical syntheses of nanophase metals, alloys, metal carbides, supported heterogeneous catalysts, and nano-colloids derives from the sonochemical decomposition of volatile organometallic precursors during cavitation, which produces clusters a few nm in diameter. Such nanostructured solids are active heterogeneous catalysts for various reactions. Most recently, we have discovered a new synthesis of nanometer-sized MoS2 and of transition metal colloids of iron, cobalt, and iron–cobalt alloy colloids. Sonication of molybdenum hexacarbonyl in the presence of sulfur produces a novel morphology of MoS2 with extremely high activity for catalytic hydrodesulfurization of thiophene. Stabilized iron, cobalt, and alloy colloids have also been prepared that are amorphous as initially prepared with particle sizes ∼5 nm as determined by TEM. Magnetic studies show that the colloids are superparamagnetic and function as useful ferrofluids.
PVREG -- a photovoltaic voltage regulation investigation tool: PVREG user's manual (1989)

This manual provides essential information for operating the computer program PVREG, a program developed to study the impact of distributed photovoltaic (PV) systems on the voltage regulation of distribution systems. The simulation consists of detailed models of the distribution system's components and a model of solar insolation and cloud systems based on typical meteorological year data. The response of the voltage regulating devices to changes in PV system outputs due to moving cloud systems is determined in discrete time steps. The number of operations of each voltage regulating device is determined, along with the feeder voltage profile. The program structure and a brief description of the models are given. A benchmark case is included to illustrate the use of the various program models.
Relating to the efficiency of utilization of the geostationary orbit/spectrum in the fixed-satellite service (1980)

Rapidly growing radio-telecommunications needs, only partially satisfiable by the use of new frequency bands, demand greater, more efficient, use of traditional frequency bands. The development of geostationary fixed-satetlite communications systems is a prime example of the pressures towards more efficient spectrum utilization. It is investigated in which manner the geostationary orbital spectrum may be utilized to produce more capacity. The major means to achieve this derive from 1) technical factors which affect the frequency reuse potential of the geostationary satellite orbit; 2) technical factors which affect the amount of information which may be transmitted in a given bandwidth; and 3) other factors which facilitate or enhance the application of the technical factors with a view towards conserving and increasing orbit and spectrum utilization. Each of the individual factors is discussed in some detail, and estimates of their impact on orbit/spectrum utilization efficiency are provided in parametric form.
Sterically Encumbered Bipyridyl-Derivatized Conjugated Polymers and Metallopolymers Incorporating Phenylenevinylene, Phenyleneethynylene, and Fluorenylene Segments (2012)

This work reports the preparation of a series of 2,2′-bipyridyl (bipy) modified π-conjugated polymers having an average of one or three monomer units (p-arylene ethynylene for PPE1 and PPE3 or 7,7-dihexylfluorene for PF1 and PF3) between metal-binding sites. Spectroscopic data demonstrate that strategic placement of sterically encumbered mesityl groups about the metal binding sites enforces a 1:1 metal to bipy binding ratio. This steric coordination control ensures that the metalated polymers remain solution processable rather than forming insoluble networks via coordinative cross-linking. The solution photophysical and electrochemical properties of metal-free and metalated materials are reported and compared with those of related conjugated polymers and conducting metallopolymers.
Comparison of haem a, the dichroic haem of heart muscle, and of porphyrin a with compounds of known structure (1951)

1. ,B-Ketoadipic acid has been shown to arise by ring fission in the metabolism of phenol and benzoic acid by a vibrio species.
The hemophilias and their clinical management (2013)

Outcomes for patients with hemophilia have improved dramatically over the past 50 years. With the increased availability of safe clotting factor concentrates, the primary focus in clinical management is now the prevention of long-term complications, most notably the debilitating hemophilic arthropathy that is associated with severe disease. This article reviews evidence-based approaches for managing both children and adults with hemophilia. Definitive evidence of improved clinical results from primary prophylaxis started in young patients with severe hemophilia A and a minimal bleeding history is presented. Furthermore, recent studies showing benefits for initiating prophylaxis in older adolescents and adults with established joint disease are examined. Inhibitors to factor VIII are the most problematic complication of factor replacement therapy. Patient-specific and treatment-related factors that contribute to the risk of inhibitor formation are discussed and controversies and clinical evidence related to approaches for tolerance induction are reviewed.