gebhart/patrepeval huggingface dataset:
Intestinal injury after blunt abdominal trauma. (1989)

腹部鈍外的外傷による腸管損傷の形態学的特徴と成因を明らかにするめに, 外科的切除例8例を臨床病理学的に検討した.肉眼形態は, 臨床・病理学的に, 穿孔型・腹腔内出血型および慢性狭窄型の3型に分類できた.穿孔型は, 空腸上部～中部と回腸末端部に見られ, 単発～多発の小穿孔を腸間膜近位部に, また粘膜の一部に虚血性びらんを伴っていた.穿孔の原因は, 腸管が直接椎体にぶつかり挫滅する場合と, 腸管内圧の急激な上昇による場合が考えられた.腹腔内出血型は腸間膜損傷と, 腸粘膜に軽度～中程度の虚血性腸炎の所見を伴っており, 後者の所見は腸間膜損傷による二次的な虚血性腸病変と思われた.慢性狭窄型は漿膜側を中心に著明な線維症とこれによる狭窄で二次的な筋層の機能性肥大を伴っており, 慢性虚血と癒着に起因すると考えられた.このように, 腹部の鈍的外傷による腸管損傷には上記のような3つの肉眼形態があり, 成因もそれぞれで異なるものと思われた.
Functional Antagonism Between YY1 and the Serum Response Factor (1992)

The rapid, transient induction of the c-fos proto-oncogene by serum growth factors is mediated by the serum response element (SRE). The SRE shares homology with the muscle regulatory element (MRE) of the skeletal alpha-actin promoter. It is not known how these elements respond to proliferative and cell-type-specific signals, but the response appears to involve the binding of the serum response factor (SRF) and other proteins. Here, we report that YY1, a multifunctional transcription factor, binds to SRE and MRE sequences in vitro. The methylation interference footprint of YY1 overlaps with that of the SRF, and YY1 competes with the SRF for binding to these DNA elements. Overexpression of YY1 repressed serum-inducible and basal expression from the c-fos promoter and repressed basal expression from the skeletal alpha-actin promoter. YY1 also repressed expression from the individual SRE and MRE sequences upstream from a TATA element. Unlike that of YY1, SRF overexpression alone did not influence the transcriptional activity of the target sequence, but SRF overexpression could reverse YY1-mediated trans repression. These data suggest that YY1 and the SRF have antagonistic functions in vivo.
Computer controlled measurement of spasticity (2002)

A portable device to quantitatively measure the degree of spasticity in the ankle of patients was developed using a computer-controlled system consisting of a pedal which is rotated through the desired range by a mechanical system driven by a d.c. stepper motor. The resistive torque from the spastic ankle is measured with a sensor system consisting of strain gauges placed in a transducer shaft which rotates the pedal. The data are retrieved by a software triggered A/D board, and the results are graphed. This device, which is yet to be clinically tested, will enable therapists to quantitatively measure the degree of spasticity in patients and record small changes in their performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Micromechanical silicon instrument and systems development at Draper Laboratory (1996)

Draper Laboratory has been developing miniature micromechanical instruments for over 10 years, using silicon microfabrication techniques to achieve high yields in a batch processing environment. During this time, considerable progress has been made in the development and fabrication of micromechanical gyroscopes, accelerometers, and acoustic sensors. Gyroscopes and accelerometers have been fabricated with measurement ranges from 50 to 500 deg/s and 10 to 100,000 g, respectively. Current design efforts center on the tuning fork gyro and the pendulous accelerometer configurations. These units have successfully performed across a temperature range of -40 to 85 deg C, and have survived 80,000 to 120,000-g shock tests along all axes. Integrated Micromechanical Inertial Sensor Assembly and GPS receiver configurations are being developed for applications from projectile guidance to small satellites. (Author)
EFEITOS DA QUALIDADE DA ÁGUA DE PULVERIZAÇÃO SOBRE A EFICÁCIA DE HERBICIDAS APLICADOS EM PÓS-EMERGÊNCIA (1998)

Com o objetivo de estudar o efeito da qualidade da água utilizada na pulverização, sobre a eficácia de herbicidas aplicados em pós-emergência, instalou-se um experimento no ano agrícola 91/92, em área da Fazenda Experimental da Faculdade de Ciências Agrárias e Veterinárias da UNESP, município de Jaboticabal (SP), com 21 tratamentos e três repetições. Os tratamentos foram constituídos pelas combinações de formulações comerciais de glifosate, mistura pronta de glifosate + 2,4D, MSMA e paraquat com as águas deionizada, destilada, limpa (poço profundo), turva 1 (limpa + 2 g.L-1 de solo) e turva 2 (limpa + 10 g.L-1 de solo), além de uma testemunha, na qual não se efetuou a aplicação de herbicidas. Avaliações visuais de controle, geral e por espécie, aos 14, 30 e 45 dias após a aplicação, mostraram que nenhum dos tipos de água utilizados interferiu significativamente na eficiência dos herbicidas, independentemente do produto e da época de avaliação. As quantidades de argila adicionadas às águas denominadas de turva 1 e turva 2 não adsorveram os herbicidas paraquat e glifosate a ponto de prejudicar-lhes a ação. A análise e interpretação dos resultados obtidos, portanto, permitem concluir que o emprego de água turva, oriunda de um reservatório aberto, foi viável para aplicação de alguns herbicidas (glifosate, glifosate + 2,4-D, MSMA e paraquat) em pós-emergência, não influenciando significativamente na sua eficácia .
Psychological status and pain outcome evaluation in patients with painful bone metastases from castration resistant prostate cancer treated with 223Radium. (2016)

e16512 Background: Radium 223 Dichloride (223Ra) has been shown to improve overall survival in men with metastatic Castration-Resistant Prostate Cancer (mCRPC) with symptomatic bone metastases. Pain is the most common symptom developed by patients (pts) with bone metastases with psychological status impairment. Our aim was to evaluate the psychological distress, (such as functional status, social support, anxiety and depression), and trend of pain response during 223Ra treatment. Methods: Our current clinical experience accounts for 39 pts affected by mCRPC and bone metastases. A total of 118 cycles were administred with 50 KBq/Kg i.v. q4w of 223Ra. Mean age was 75,2±6,07. Gleason Score average value was 8 and ECOG Performance Status mean value was 1,48. Pts were evaluated with Brief Pain Inventory (BPI 0-10 Scale) and data were collected. To examine quality of life (QoL) endpoints, pts were asked to complete the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) and the bone metastasis module, QLQ-BM22. Both were submitted at baseline and after every cycle of therapy. Edmonton Symptom Assessment Scale (ESAS) was used with the same timing to evaluate response to treatment. Results: 39 pts underwent 1 cycle of therapy with 223Ra. Of these 43% had psychological distress, with an average value of 7,6 in BPI Scale for pain outcome. Second cycle was administered to 33 pts. Pain mean value of these pts was 7,13 and psychological distress was present in 35%. The evaluation of functional scales after third cycle showed that of 29 pts, 32% had psychological distress with a pain average value of 6,4. Analyzing pts that underwent 6 cycles showed that 27% present psychological distress and the mean value of BPI was 5,6. Conclusions: 223Ra therapy shows a multidimensional impact on quality of life, in particular as regards psychosocial aspects. In patients with painful bone metastases from CRPC there is a strong direct relationship between pain reduction and improvement of the subjective psychological distress.
<title>Three buffer-allocation schemes for a MAP/PH/1/K priority queue with vacations and an application to ATM networks</title> (1997)

A discrete-time finite buffer capacity queueing system for a generic multimedia shared medium is studied in this paper. In such an environment, the arrival process at the aggregate level (e.g., frame arrival rather than cell arrival) can be captured using the Markovian arrival process and the service time can be represented by the phase type service. The quality of service can be increased through the assignment of priority and buffer allocation scheme. In this paper, we consider two types of priorities and three buffer allocation schemes. First, we consider priority service and non-priority buffer allocation, second, priority service and fixed buffer allocation, and third, priority service with priority buffer allocation with push-out and threshold. Our analysis leads to the queue length distribution and the blocking probability. In addition, we show that the throughput can be obtained as a Markov renewal process described by two sub-stochastic matrices derived by partitioning the transition matrix. Through several numerical examples, we show the effect of buffer allocation scheme on the throughput, and present some results for the average queue length, blocking probability, and the throughput.
Effect of tumor necrosis factor on human tumor cell lines sensitive and resistant to cytotoxic drugs, and its interaction with chemotherapeutic agents (1990)

We investigated the cytotoxic effects of recombinant tumor necrosis factor (TNF) alone and in combination with interferon-gamma (IFN-gamma) and/or cytotoxic drugs on a variety of human tumor cell lines (U937, IGROV-1, HT29, LoVo, MCF7 and U20S), including cell lines with in vitro acquired resistance (LoVo/DX and MCF7/DX selected for resistance to doxorubicin (DX) and characterized by pleiotropic drug resistance; U20S selected for resistance to cisplatin (CDDP], using MTT assay. U937 and MCF7 were sensitive to the cytotoxic effect of TNF, whereas all the other cells were insensitive up to 1000 U/ml (the maximum tested dose). Surprisingly, TNF was cytotoxic (30-40% cytotoxicity) against two resistant lines (LoVo/DX and U20S/Pt) but not against the parent sensitive lines. Treatment with increasing doses of TNF after 6 h incubation with a subtoxic concentration of IFN-gamma produced a synergistic effect in four cell lines (U937, HT29, LoVo/DX and MCF7), whereas in the other five the cell killing of the combination was comparable with that achieved by TNF alone. The combination of subtoxic doses of TNF and increasing doses of drugs targeted at DNA topoisomerase II (i.e. DX, actinomycin D and VP16) produced an additive cytotoxic effect in all cell lines. The same results were obtained combining TNF and CDDP, except in U20S/Pt cells in which TNF synergistically increased CDDP cytotoxicity. The combination of TNF and IFN-gamma enhanced cytotoxicity about 20-fold for DX and 6-fold for CDDP, evaluated in terms of the modification index, against LoVo/DX and U20S/Pt cells respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Global Carbon Utilization Profiles of Wild-Type, Mutant, and Transformant Strains of Hypocrea jecorina (2006)

The ascomycete Hypocrea jecorina (Trichoderma reesei), an industrial producer of cellulases and hemicellulases, can efficiently degrade plant polysaccharides. However, the catabolic pathways for the resulting monomers and their relationship to enzyme induction are not well known. Here we used the Biolog Phenotype MicroArrays technique to evaluate the growth of H. jecorina on 95 carbon sources. For this purpose, we compared several wild-type isolates, mutants producing different amounts of cellulases, and strains transformed with a heterologous antibiotic resistance marker gene. The wild-type isolates and transformed strains had the highest variation in growth patterns on individual carbon sources. The cellulase mutants were relatively similar to their parental strains. Both in the mutant and in the transformed strains, the most significant changes occurred in utilization of xylitol, erythritol, D-sorbitol, D-ribose, D-galactose, L-arabinose, N-acetyl-D-glucosamine, maltotriose, and beta-methyl-glucoside. Increased production of cellulases was negatively correlated with the ability to grow on gamma-aminobutyrate, adonitol, and 2-ketogluconate; and positively correlated with that on d-sorbitol and saccharic acid. The reproducibility, relative simplicity, and high resolution (+/-10% of increase in mycelial density) of the phenotypic microarrays make them a useful tool for the characterization of mutant and transformed strains and for a global analysis of gene function.
Bentiromide:xylose test in healthy cats. (1982)

The N-benzoyl-L-tyrosyl-p-aminobenzoic acid (bentiromide):xylose test for simultaneous evaluation of pancreatic exocrine function and intestinal absorptive function was studied in 8 clinically healthy cats. Plasma p-aminobenzoic acid (PABA) and xylose concentrations were determined before, and at 30, 60, 90, 120, 150, and 180 minutes after, a solution of bentiromide (1 g/100 ml) and D-xylose (10 g/100 ml) was given orally at a dosage of 5 ml/kg of body weight. The peak plasma concentrations for PABA occurred between 60 and 120 minutes, with highest mean value at 90 minutes (7.5 +/- 3.2 micrograms/ml), and for xylose between 30 and 120 minutes, with the highest mean value at 60 minutes (42.6 +/- 17.8 mg/dl). Large SD in plasma PABA and xylose concentrations indicated marked individual variation between healthy cats. It was concluded that (i) large variations between clinically healthy cats may limit the diagnostic usefulness of the bentiromide:xylose test in the cat, and (ii) guidelines for interpretation of plasma PABA and xylose concentrations reported previously for clinically healthy dogs could not be applied to cats because values were lower in cats.
Éloignement des services publics : Contraintes et sens critique (2011)

Professionnels de la santé et chercheurs se préoccupent de plus en plus des populations précaires qui, malgré un état de santé défavorable, sont " éloignées " du système de soins ou en " non-recours " aux soins. Ces situations ont de quoi surprendre et viennent interroger l'effectivité des dispositifs destinés à favoriser l'accès aux soins de tous. Comment, dès lors, les comprendre ? Les entretiens que nous avons menés, dans le contexte français, avec les individus concernés démontrent comment ils expliquent et vivent ces situations. Si certains reviennent sur les obstacles qui les maintiennent à l'écart du système de soins, d'autres insistent sur la volonté de prendre en charge eux-mêmes leur santé. C'est sur l'autonomie et ses différentes significations que nous reviendrons en particulier car elle permet d'éclairer sous un autre angle le non-recours aux soins.
Natural moisturizing factor as a clinical marker in atopic dermatitis (2019)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
New data on painite (1986)

Abstract A crystal of painite discovered in 1979 in a parcel of rough gem spinel from Burma represents the third known crystal of the species. This crystal is similar to the type crystal in most respects. Chemical analyses of both the new crystal and the type crystal confirmed the essential constituents reported by Moore and Araki (1976) and showed in addition the presence of trace amounts of Fe, Cr, V, Ti, Na, and Hf. Optical absorption spectra suggest that the red colour of painite is caused principally by Cr 3+ and V 3+ .
Single‐Molecule Switching: Fluorescence Polarization Control for On–Off Switching of Single Molecules at Cryogenic Temperatures (Small Methods 9/2018) (2018)

In article number 1700323, a sparsity-inducing scheme based on widefield stimulated emission depletion, which requires stringent control of the polarization state of both the excitation and depletion laser, is introduced by Bernd Rieger and co-workers for superresolution fluorescence microscopy. The ideal state involves excitation and depletion lasers with linear polarizations, orthogonally oriented in the sample plane. This state is obtained from linearly polarized light from the laser, which is made elliptically polarized before reflecting off the dichroic mirror.
Immunocytochemical detection of circulating esophageal carcinoma cells by immunomagnetic separation. (2001)

Immunocytochemical detection of circulating carcinoma cells by IMS may be a specific method for the diagnosis of systemic disease and for monitoring treatment response.
Long-term efficacy and safety of nalfurafine hydrochloride on pruritus in chronic liver disease patients: Patient-reported outcome based analyses (2017)

Nalfurafine hydrochloride contributed to long-term suppression of pruritus without significant safety problems.
Multidimensional Nuclear Magnetic Resonance of Biomolecules (2008)

Abstract Nuclear magnetic resonance (NMR) is associated with transitions, induced by radiofrequency (RF) irradiation, between energy levels of nuclei with nonzero spin quantum numbers in a magnetic field. Traditional “one‐dimensional” (1‐D) NMR spectra are presented as a plot of signal intensity versus applied frequency and provide information about the chemical environment of magnetically active nuclei. This is used to deduce information about the chemical structure and dynamics of molecules containing the magnetically active nuclei (most often protons). The frequencies of individual nuclei are referred to as their chemical shifts. Multidimensional NMR encompasses a range of related techniques, based on the application of a variety of precisely timed RF pulses to the sample, which extends traditional 1‐D NMR into two‐, three‐, or four‐frequency dimensions. These additional frequency dimensions may be the same as the first frequency dimension, referred to as homonuclear multidimensional NMR, or different, referred to as heteronuclear NMR. In multidimensional NMR of biomolecules, the most common frequencies correspond to 1 H in the directly detected dimension and one or more of 1 H , 13 C , or 15 N in the additional dimensions. Peaks in such spectra are defined by their intensity and frequency coordinates in two, three, or four dimensions obtained by extrapolation back to the respective frequency axes, which are in turn determined by the nature of the applied RF pulse sequences. The intensity and chemical shifts of such peaks provide information about the chemical environment, molecular connectivity, or spatial proximity of the participating nuclei. Multidimensional NMR has major advantages over 1‐D NMR: reduction of peak overlap and provision of information on connectivity (either through bonds or through space). Multidimensional NMR spectroscopy of biomolecules is usually done for samples in solution at millimolar concentration. Where experiments require the use of 13 C or 15 N frequencies, it is usually necessary to isotopically enrich the macromolecule with these nuclei to &gt;90%. This is readily achieved with modern molecular biology techniques and does not present a major limitation. The biggest limitation relates to molecular size, with studies generally limited to macromolecules of less than approximately 35 kDa.
Input Differential-Mode EMI of CRM Boost PFC Converter (2012)

In this paper, the differential-mode (DM) electromagnetic interference (EMI) noise of a single-phase boost power factor correction converter operating in critical current mode was analyzed. The DM noise spectra are calculated based on the mathematical model of EMI receiver and the required corner frequencies of DM filter are obtained. It can be seen that the minimum corner frequencies are determined by the maximum noises at 150 kHz. With the relation between the magnitude of the inductor current ripple and the DM noise, the characteristics of noise at 150 kHz are obtained by analyzing the current ripple magnitude at 150 kHz; thus, the worst conditions which have the maximum noise value are figured out. Meanwhile, the maximum noises at 150 kHz for different input voltages are identical, so the DM filter can be designed based on one worst spectrum at one input voltage without testing the spectra in other conditions.
Gorilla APOBEC3 restricts SIVcpz and influences lentiviral evolution in great ape cross-species transmissions (2018)

Summary Restriction factors including APOBEC3 family proteins have the potential prevent cross-species lentivirus transmissions. Such events as well as ensuing pathogenesis require the viral Vif protein to overcome/neutralize/degrade the APOBEC3 enzymes of the new host species. Previous investigations have focused on the molecular interaction between human APOBEC3s and HIV-1 Vif. However, the evolutionary interplay between lentiviruses and great ape (including human, chimpanzee and gorilla) APOBEC3s has not been fully investigated. Here we demonstrate that gorilla APOBEC3G plays a pivotal role in restricting lentiviral transmission from chimpanzee to gorilla. We also reveal that a sole amino acid substitution in Vif is sufficient to overcome the gorilla APOBEC3G-mediated species barrier. Moreover, the antiviral effects of gorilla APOBEC3D and APOBEC3F are considerably weaker than those of human and chimpanzee counterparts, which can result in the skewed evolution of great ape lentiviruses leading to HIV-1. Highlights SIVcpz requires M16E mutation in Vif to counteract gorilla A3G Acidic residue at position 16 of Vif is crucial to counteract gorilla A3G Gorilla A3D and A3F poorly suppress lentiviral infectivity SIVgor and related HIV-1s counteract human A3D and A3F independently of DRMR motif
Electrochemistry: Development and Simulation of Sulfur‐doped Graphene Supported Platinum with Exemplary Stability and Activity Towards Oxygen Reduction (Adv. Funct. Mater. 27/2014) (2014)

Unique sulfur-doped graphene-supported platinum nanoparticles prepared by Z. Chen and co-workers provide excellent oxygen reduction activity and stability, rendering them highly attractive electrode materials for fuel cell applications. On page 4325, the enhancements arise due to specific interactions between the sulfur dopant atoms and the platinum nanoparticles, leading to a “tethering” effect that increases the stability and modulates the electronic properties that improve the activity.
Interaction Properties of the Procollagen C-proteinase Enhancer Protein Shed Light on the Mechanism of Stimulation of BMP-1 (2002)

Procollagen C-proteinase enhancer (PCPE) is an extracellular matrix glycoprotein that binds to the C-propeptide of procollagen I and can enhance the activities of procollagen C-proteinases up to 20-fold. To determine the molecular mechanism of PCPE activity, the interactions of the recombinant protein with the procollagen molecule as well as with its isolated C-propeptide domain were studied using surface plasmon resonance (BIAcore) technology. Binding required the presence of divalent metal cations such as calcium and manganese. By ligand blotting, calcium was found to bind to the C-propeptide domains of procollagens I and III but not to PCPE. By chemical cross-linking, the stoichiometry of the PCPE/C-propeptide interaction was found to be 1:1 in accordance with enzyme kinetic data. The use of a monoclonal antibody directed against the N-terminal region of the C-propeptide suggested that this region is probably not involved in binding to PCPE. Association and dissociation kinetics of the C-propeptide domains of procollagens I and III on immobilized PCPE were rapid. Extrapolation to saturation equilibrium yielded apparent equilibrium dissociation constants in the range 150-400 nM. In contrast, the association/dissociation kinetics of intact procollagen molecules on immobilized PCPE were relatively slow, corresponding to a dissociation constant of 1 nM. Finally, pN-collagen (i.e. procollagen devoid of the C-terminal propeptide domain) was also found to bind to immobilized PCPE, suggesting that PCPE binds to sites on either side of the procollagen cleavage site, thereby facilitating the action of procollagen C-proteinases.