gebhart/patrepeval huggingface dataset:
EFFECT OF BROMOCRIPTINE IN PITUITARY-DEPENDENT CUSHING'S SYNDROME (1976)

Department of Medicine III and Clinical Endocrinology, University Hospital 'Dijkzigt', Erasmus University, Rotterdam, The Netherlands (Received 16 February 1976) The role of catecholamines in modulating the secretion of adrenocorticotrophin (ACTH) has been investigated by numerous workers with conflicting results (van Loon, 1973). In some of these studies l-DOPA has been used, which induces the production of adrenaline and noradrenaline in addition to that of dopamine. Recently 2-bromo-α-ergocryptine became available; this drug seems to be a more specific activator of the dopaminergic pathways in the central nervous system (Corrodi, Fuxe, Hökfelt, Lidbrink & Ungerstedt, 1973). On the basis of a recent observation, that the daily administration of 0·05 mg ergotamine to rats bearing ACTH-secreting pituitary tumours inhibited tumour growth and reversed adrenal enlargement (Macleod & Lehmeyer, 1973), we investigated the effect of bromocriptine on plasma ACTH levels in seven patients with pituitary-dependent Cushing's syndrome (one with a pituitary tumour) and four
Hydrodemetallization and hydroconversion of Tia Juana heavy vacuum residue with dual catalyst systems (1987)

The current surplus of crude and lower prices may not last forever. In the long term, it is realized that there will be a decreasing supply of light oils, thus, it will be necessary to utilize the huge reserves of heavy crude available in Canada and Venezuela. The main drawback for the processing of these crudes is the high metal, sulfur and asphaltene content which make them not amenable for conventional refining. Metals such as nickel and vanadium, are undesirable contaminants for catalysts. As crude passes through the refinery, the metals congregate in the residues and, generally speaking, the heavier the crude the higher the metal content. In order to deal with high metals crude, they are engaged in the development of a process scheme for the upgrading of heavy crudes. The process consists of an up-flow fixed bed catalyst system with a first stage catalyst selective to hydrodemetallization followed by a thermal cracking zone and a second stage catalyst selective to hydroconversion. In the present paper, recent results of life tests to study the performance of dual catalyst systems are presented. Results of hydrodemetallization and hydroconversion of the 540{degree}c fraction of Tia Juana heavy resid are discussed. In addition,more » results of the screening study to select this dual catalyst system are also presented.« less
Synthesis and Structural Characterization of a Dinuclear Palladium(II) Complex with N,N',N'',N'''-Tetrakis(2-p-toluenesulfonamidoethyl)cyclam (2008)

Abstract Dinuclear palladium(II) complex with 1,4,8,11-tetrakis(2-p-toluenesulfonamidoethyl)-1,4,8,11-tetraazacyclotetradecane (H4tstaec), [Pd2(tstaec)], was synthesized and characterized by elemental analysis and IR and UV–vis spectroscopies. The crystal structures of H4tstaec and [Pd2(tstaec)] were determined by single-crystal X-ray diffraction method. In the former ligand, the cyclam ring moiety takes a trans IV conformation with the tosyl arms pointing away from each other, whereas each palladium atom is bound by two nitrogen atoms of the cyclam moiety and two nitrogen atoms of the tosyl arms with Pd···Pd distance of 5.617(1) Å intervening the trans IV cyclam ring in the latter complex. DFT calculations were performed based on these crystal structures.
Electrophoretic and functional properties of mustard seed meals and protein concentrates (2004)

Abstract Defatted meals and protein concentrates from five varieties of mustard seeds (four Brassica spp. and one Sinapis alba ) were analyzed for polypeptide composition and functional properties. Nonreducing gel electrophoresis showed that Brassica seeds lacked the 135‐ and 50‐kDa polypeptides that were present in the seeds of the S. alba variety. On the other hand, the 29‐kDa polypeptide found in the Brassica seeds was absent from the seed of the S. alba variety. Under reducing conditions, the 135 kDa was not detected in the S. alba variety and the intensity of the 50‐kDa polypeptide was severely reduced; in contrast, the intensity of the 29‐kDa polypeptide in the Brassica seeds was not affected. Meals from yellow seeds had significantly higher ( P ≤0.05) protein contents than meals from the brown seeds. The emulsifying activity indexes (EAI) of meals and protein concentrates from the Brassica seeds were significantly higher ( P ≤0.05) than those obtained for similar products from S. alba sees. It was concluded that the disulfide‐bonded 50‐ and 135‐kDa polypeptides may have contributed to increased rigidity of S. alba meal proteins, which resulted in poor EAI when compared to the Brassica meals, which do not contain these polypeptides.
Untersuchungen zum ternären System Bi/Te/O, II. Thermisches Verhalten und Koexistenzbeziehungen von Bi2O2Te/Investigations of the Ternary System Bi/Te/O, II. The Thermal Behaviour and the Relations of Phase Coexistences of Bi2O2Te (1997)

Abstract The phase Bi 2 O 2 Te exists in the pseudobinary system Bi 2 O 3 /Bi 2 Te 3 . The thermal behaviour of Bi 2 O 2 Te was determined by DTA and X-ray analysis: The phase exists up to 620 °C and decomposes into the solid phases Bi 12 TeO 20 , Bi 10 Te 2 O 19 [1] and liquid BiTe. The relations of the phase coexistences in the pseudobinary system and in the ternary area Bi 2 O 3 /TeO 2 /Bi 2 Te 3 /Te were investigated by solid state reactions, chemical transport reactions, and by total pressure measurements.
Coriolis-Massedurchflussmesser mit direkter Viskositätsmessung (Coriolis-mass-flowmeter with Direct Viscosity Measurement) (2004)

Abstract Massedurchfluss-Messgeräte nach dem Coriolisprinzip haben sich schon seit langem als präzise und robuste Feldgeräte bewährt. Diese Geräte lieferten schon bisher Prozessinformationen über Durchfluss, Dichte und Temperatur. Nun ist es gelungen, auch noch den wichtigen Prozessparameter Viskosität gleichzeitig und unabhängig zu erfassen. Damit steht ein wirklich „multivariables“ Prozessmessgerät zur Verfügung.
Imaging lung water redistribution using 0.55T ultrashort echo time MRI (2023)

Quantification of changes in lung water using MRI may provide clinical value in early diagnosis of heart failure. In this study, we demonstrate the ability of our 3D free-breathing spiral ultrashort-TE sequence to quantify and capture changes in lung water using a high-performance 0.55T MRI system. A phantom containing mixtures of water and deuterium oxide at varying concentrations was used to validate water density quantification. Our proposed approach captured the gravity-induced redistribution of lung water, achieved by imaging subjects in the supine and prone positions.
Therapeutic implication of HER2 in advanced biliary tract cancer (2016)

Currently, there is no validated therapeutic target for biliary tract cancer (BTC). This study aimed to investigate the pre-clinical and clinical implication of HER2 as a therapeutic target in BTC. We established two novel HER2-amplified BTC cell lines, SNU-2670 and SNU-2773, from gallbladder cancer patients. SNU-2670 and SNU-2773 cells were sensitive to trastuzumab, dacomitinib, and afatinib compared with nine HER2-negative BTC cell lines. Dacomitinib and afatinib led to G1 cell cycle arrest in SNU-2773 cells and apoptosis in SNU-2670 cells. Furthermore, dacomitinib, afatinib, and trastuzumab showed synergistic cytotoxicity when combined with some cytotoxic drugs including gemcitabine, cisplatin, paclitaxel, and 5-fluorouracil. In a SNU-2670 mouse xenograft model, trastuzumab demonstrated a good anti-tumor effect as a monotherapy and in combination with gemcitabine increasing apoptosis. In our clinical data, 13.0% of patients with advanced BTC were defined as HER2-positive. Of these, three patients completed HER2-targeted chemotherapy. Two of them demonstrated a partial response, and the other one showed stable disease for 18 weeks. In summary, these pre-clinical and clinical data suggest that HER2 could be a therapeutic target, and that a HER2-targeting strategy should be developed further in patients with HER2-positive advanced BTC.
Subunit‐specific P2X‐receptor expression defines chemosensory properties of trigeminal neurons (2004)

The facial innervation pattern of trigeminal nerve fibres comprises the innervation of the nasal epithelium, where free trigeminal nerve endings contribute to detection and discrimination of chemical stimuli including odourants. The signal transduction mechanisms in sensory nerve endings underlying perception of chemical stimuli remain widely uncovered. Here, we characterized trigeminal ATP-activated P2X receptors in cultured rat trigeminal neurons and investigated their role in chemoperception. We identified a new subpopulation of neurons lacking typical nociceptive characteristics and expressing homomeric P2X(2) receptors. Using a certain group of chemicals known as trigeminal stimuli we found no direct activation of trigeminal neurons, but a modulation of P2X(2) receptor mediated currents. In contrast, P2X(3) receptor mediated currents of nociceptive trigeminal neurons remained unaffected by the tested chemicals. Therefore, we assume a functional role for the newly identified subpopulation in chemodetection of certain trigeminal stimuli.
Ellipsoid-shaped superparamagnetic nanoclusters through emulsion electrospinning (2015)

Ellipsoid-shaped nanoclusters composed of single superparamagnetic nanoparticles can be generated by emulsion electrospinning. Stretching and subsequent solvent evaporation of iron oxide loaded emulsion droplets during the emulsion electrospinning process enables the creation of such structures embedded in polymer nanofibers. Dissolution of the polymer fibers yields an aqueous dispersion of the inorganic clusters which are the first example of ellipsoid-shaped superparamagnetic nanoclusters with a high saturation magnetization (∼47 emu g(-1)).
Genotypic and phenotypic analysis of zwittermicin A-producing strains of Bacillus cereus (1996)

Many strains of Bacillus cereus produce zwittermicin A, a novel antibiotic that contributes to the ability of B. cereus to suppress certain plant diseases. The purpose of this study was to identify molecular indicators of zwittermicin A production in B, cereus strains, contribute to an understanding of the ecology and evolution of this group of bacteria, and identify potential agents for control of plant disease. The fatty acid composition of 20 strains known to be zwittermicin A producers and 20 strains known to be non-producers was determined. Cluster analysis of the fatty acid methyl ester (FAME) profiles revealed that zwittermicin A producers grouped together in two clusters, apart from most non-producers. Discriminant analysis of the FAME profiles generated models that correctly predicted the zwittermicin A-production phenotype in 17 of 20 zwittermicin A producers and 17 of 20 non-producers. Sixteen random oligonucleotide primers were tested in PCR, and one primer was identified that generated a fragment of 0.48 kb or 0.49 kb from total DNA from 26 of 28 strains known to produce zwittermicin A, whereas PCR with this primer did not generate bands of that size from 16 of 20 non-producing strains. PCR with primers designed to amplify zmaR, a gene from B. cereus that confers resistance to zwittermicin A, generated DNA fragments of 1.1 kb and 1.0 kb in all 29 zwittermicin A-producing strains tested, amplified a fragment of 0.3 kb in some of the zwittermicin A-producing strains, and amplified no fragments in 20 of 23 non-producing strains in a stock collection of B. cereus strains. The zmaR primers were tested for their ability to identify new zwittermicin A-producing isolates of B. cereus from two soils. All 12 of the isolates that produced the banding pattern characteristic of this primer pair produced zwittermicin A, and none of the 12 isolates that did not have the banding pattern produced detectable zwittermicin A. Seven of the 12 isolates initially identified as zwittermicin A producers with the zmaR primers significantly suppressed damping-off of alfalfa, whereas only one of the non-producers suppressed this disease. The results show that FAME and PCR analyses distinguish B. cereus strains that produce zwittermicin A from other B. cereus strains, that PCR with the primers designed to amplify zmaR is the most reliable method of those tested for identification of zwittermicin A producers, and that this method can be used to identify new strains with disease-suppressive activity.
Homochiral 2,5-disubstituted 3-fluorotetrahydrofurans carrying differently functionalized ring appendages (1989)

With (R)-1-sulphinyl-3-fluoropropan-2-one (1) as starting material a multistep approach is described for the asymmetric synthesis of various 3-fluorotetrahydrofurans of type (7)–(12) which carry differently functionalized 2- and 5-methyl groups.
The anatomy of the coronary sinus venous system for the cardiac electrophysiologist (2009)

Cardiac electrophysiologists' use of the coronary sinus (CS) to map and ablate accessory pathways and implant left ventricular leads has emphasized the need for understanding CS anatomy. In this review, we briefly examine the developmental and radiological anatomy of the CS and discuss in detail the gross anatomy of this cardiac vein. We highlight the correlations of the acquired anatomical knowledge relevant to clinical electrophysiology practice.
Overview of NRL's maritime laser communication test facility (2005)

NRL has established a 20 mile round trip laser communication test facility across the Chesapeake Bay for investigating lasercomm performance in a maritime environment. Experiments at this facility have successfully demonstrated links at data rates up to 2.5 Gbps and at lower rates in light rain and fog. This facility is currently being upgraded to allow long term monitoring of a one-way 10 mile link across the Bay. Parameters monitored will include BER, turbulence conditions, atmospheric transmission, and meteorological conditions. A summary of past results, the design/status of the upgrade to the test facility, and recent results will be presented.
Visual Cortex Neurons of Monkeys and Cats: Temporal Dynamics of the Spatial Frequency Response Function (2004)

We measured the responses of striate cortex neurons as a function of spatial frequency on a fine time scale, over the course of an interval that is comparable to the duration of a single fixation (200 ms). Stationary gratings were flashed on for 200 ms and then off for 300 ms; the responses were analyzed at sequential 1-ms intervals. We found that 1) the preferred spatial frequency shifts through time from low frequencies to high frequencies, 2) the latency of the response increases as a function of spatial frequency, and 3) the poststimulus time histograms (PSTHs) are relatively shape-invariant across spatial frequency. The dynamic shifts in preferred spatial frequency appear to be a simple consequence of the latency shifts and the transient nature of the PSTH. The effects of these dynamic shifts on the coding of spatial frequency information are examined within the context of several different temporal integration strategies, and pattern-detection performance is determined as a function of the interval of integration, following response onset. The findings are considered within the context of related investigations as well as a number of functional issues: motion selectivity in depth, "coarse-to-fine" processing, direction selectivity, latency as a code for stimulus attributes, and behavioral response latency. Finally, we demonstrate that the results are qualitatively consistent with a simple feedforward model, similar to the one originally proposed in 1962 by Hubel and Wiesel, that incorporates measured differences in the response latencies and the receptive field sizes of different lateral geniculate nucleus inputs.
Inhaled Nitric Oxide Potentiates Actions of Adenosine but Not of Sodium Nitroprusside in Experimental Pulmonary Hypertension (1999)

Inhaled nitric oxide (NO), a selective pulmonary vasodilator, increases intracellular cyclic guanosine monophosphate. In contrast, adenosine, another selective pulmonary vasodilator, increases intracellular cyclic adenosine monophosphate. There has been only limited study on effects of inhaled NO combined with other pulmonary vasodilators. The current study examined the hypothesis that inhaled NO would potentiate in vivo pulmonary vasodilator effects of adenosine, but not those of sodium nitroprusside (SNP). Like inhaled NO, SNP acts via cyclic guanosine monophosphate. Rabbits were anesthetized and mechanically ventilated. The NO synthesis inhibitor NG-nitro-L-arginine methyl ester was administered. U46619, a thromboxane A2 mimetic, was infused to produce pulmonary hypertension. Rabbits then received either SNP at doses of 0.5, 1, 2, 4, 8, 16, and 32 microg/kg/min or adenosine at doses of 12.5, 25, 50, 100, 150, and 300 microg/kg/min. Hemodynamic measurements were obtained with or without inhaled NO (40 ppm) at each dose of SNP or adenosine. During U46619-induced pulmonary hypertension, inhaled NO decreased pulmonary artery pressure and pulmonary vascular resistance. Adenosine and SNP produced dose-related decreases in pulmonary artery pressure and pulmonary vascular resistance and increases in cardiac output. Inhaled NO decreased pulmonary artery pressure and pulmonary vascular resistance at all doses of adenosine, but had no significant pulmonary vasodilator effects at doses of SNP >0.5 microg/kg/min. We conclude that inhaled NO does not produce additional pulmonary vasodilation over that achieved at higher doses of SNP, but does produce additional vasodilation when combined with a vasodilator having different mechanisms of action. Since both inhaled NO and adenosine produce selective pulmonary vasodilation, such combination therapy may be effective in patients with pulmonary hypertension.
Type III Secretion Contributes to the Pathogenesis of the Soft-Rot Pathogen Erwinia carotovora: Partial Characterization of the hrp Gene Cluster (2001)

The virulence of soft-rot Erwinia species is dependent mainly upon secreted enzymes such as pectinases, pectin lyases, and proteases that cause maceration of plant tissue. Some soft-rot Erwinia spp. also harbor genes homologous to the hypersensitive reaction and pathogenesis (hrp) gene cluster, encoding components of the type III secretion system. The hrp genes are essential virulence determinants for numerous nonmacerating gram-negative plant pathogens but their role in the virulence of soft-rot Erwinia spp. is not clear. We isolated and characterized 11 hrp genes of Erwinia carotovora subsp. carotovora. Three putative sigmaL-dependent Hrp box promoter sequences were found. The genes were expressed when the bacteria were grown in Hrp-inducing medium. The operon structure of the hrp genes was determined by mRNA hybridization, and the results were in accordance with the location of the Hrp boxes. An E. carotovora strain with mutated hrcC, an essential hrp gene, was constructed. The hrcC- strain was able to multiply and cause disease in Arabidopsis, but the population kinetics were altered so that growth was delayed during the early stages of infection.
Magnetic Field Dependence of Molecular Quantum Beat: Biacetyl (1980)

Abstract The effect of an external magnetic field on the decay of an excited single rotational state of the 1 A u electronic state of biacetyl is observed in a hypersonic jet experiment after narrow bandwidth laser excitation. The lifetime of the ex-cited state decreases already at low magnetic fields and the molecular quantum beat vanishes.
Yeast Dam1p has a role at the kinetochore in assembly of the mitotic spindle (2001)

During mitosis, replicated chromosomes are separated to daughter cells by the microtubule-based mitotic spindle. Chromosomes attach to the mitotic spindle through specialized DNA/protein structures called kinetochores, but the mechanism of attachment is not well understood. We show here that the yeast microtubule-binding protein, Dam1p, associates physically and functionally with kinetochores, suggesting a role in kinetochore attachment to the spindle. An epitope-tagged version of Dam1p colocalizes with the integral kinetochore component Ndc10p/Cbf2p in immunofluorescence analysis of chromosome spreads. In addition, Dam1p is associated preferentially with centromeric DNA as shown by chromatin immunoprecipitation experiments, and this association depends on Ndc10p/Cbf2p. We also demonstrate genetic interactions between DAM1 and CTF19 or SLK19 genes encoding kinetochore proteins. Although the defect caused by the dam1 - 1 mutation leads to activation of the spindle checkpoint surveillance system and consequent persistence of sister chromatid cohesion, the metaphase arrest spindle abnormally elongates, resulting in virtually complete chromosome missegregation. Execution point experiments indicate that Dam1p has a role in formation of a metaphase spindle and in anaphase spindle elongation. Finally, we have observed that the protein encoded by the dam1 - 1 allele becomes delocalized at the nonpermissive temperature, correlating with the subsequent onset of the mutant phenotype. Our studies are consistent with a role for Dam1p in attachment of sister chromatids through the kinetochore to the mitotic spindle before chromosome segregation.
[Medicamentous therapy of alcoholic polyneuropathy. Randomized double-blind study comparing 2 vitamin B preparations and a nucleotide preparation]. (1996)

In a randomized double-blind study involving 303 patients with alcoholic polyneuropathy the efficacy and tolerability of the combinations thiamine/pyridoxine, benfotiamine/pyridoxine, and the nucleotides of cytidine and uridine administered orally for 21 days were compared. Pain and paraesthesia, measured on a visual 10-cm-long analogue scale, as also pallaesthesia and the strength of the dorsiflexion and plantar flexors of the foot, clearly improved in all treatment groups. Clinically relevant differences in efficacy were not observed. All the drugs tested were well tolerated.
Structure-antibacterial activity relationships of anacardic acids (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure-antibacterial activity relationships of anacardic acidsIsao. Kubo, Hisae. Muroi, Masaki. Himejima, Yoshiro. Yamagiwa, Hiroyuki. Mera, Kimihiro. Tokushima, Shigeo. Ohta, and Tadao. KamikawaCite this: J. Agric. Food Chem. 1993, 41, 6, 1016–1019Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/jf00030a036https://doi.org/10.1021/jf00030a036research-articleACS PublicationsRequest reuse permissionsArticle Views980Altmetric-Citations125LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts