gebhart/patrepeval huggingface dataset:
[Incidental findings of maternal genetic abnormalities during non-invasive prenatal screening]. (2018)

The non-invasive prenatal test (NIPT) has recently been added in our clinical practice. Sensitivity and specificity of this method in the common fetal aneuploidies screening is about 99 %. This technique remains a screening test, not a diagnosis test, because false positive or negative results exist. The discordant results are explained by the method itself witch analyses the whole free circulating DNA in the maternal blood: the fetal DNA from trophoblastic cells lysing but also the maternal DNA. Placenta confined mosaic is the main false positive cause reported in the literature. NIPT can rarely reveal maternal abnormalities. We are reporting two cases carrying a cytogenetic anomaly revealed with NIPT: microduplication of 22q11.2 and a sexual chromosomes anomaly.
Filtering Test Case Selection for Increasing the Performance of Regression Testing (2015)

Under the concept of using software testing, the problems are preparing the smallest size of the selected test cases, fixing bugs, predicting the estimated testing time and numbers of the tester. The traditional methods are developed to solve these issues. Unfortunately, they cannot be applied for all reasons. Therefore, the filtering test case selection model is proposed to solve these problems and to increase the efficiency of the regression testing. It prepares the methods of filtering, classifying, and selecting the appropriate test cases. Accordingly, it gives the smaller size of the selected test cases than the traditional selections as 0.23–3.96%. When consider the fault rate measured by the developed technique is also less than those methods equivalent to 13–69%. Furthermore, the testing time and the amount of testers are also less than the comparative studies as about 2–71%, and 13–69% respectively.
Tectono-stratigraphic evolution and crustal architecture of the Orphan Basin during North Atlantic rifting (2016)

The Orphan Basin is located in the deep offshore of the Newfoundland margin, and it is bounded by the continental shelf to the west, the Grand Banks to the south, and the continental blocks of Orphan Knoll and Flemish Cap to the east. The Orphan Basin formed in Mesozoic time during the opening of the North Atlantic Ocean between eastern Canada and western Iberia–Europe. This work, based on well data and regional seismic reflection profiles across the basin, indicates that the continental crust was affected by several extensional episodes between the Jurassic and the Early Cretaceous, separated by events of uplift and erosion. The preserved tectono-stratigraphic sequences in the basin reveal that deformation initiated in the eastern part of the Orphan Basin in the Jurassic and spread towards the west in the Early Cretaceous, resulting in numerous rift structures filled with a Jurassic–Lower Cretaceous syn-rift succession and overlain by thick Upper Cretaceous to Cenozoic post-rift sediments. The seismic data show an extremely thinned crust (4–16 km thick) underneath the eastern and western parts of the Orphan Basin, forming two sub-basins separated by a wide structural high with a relatively thick crust (17 km thick). Quantifying the crustal architecture in the basin highlights the large discrepancy between brittle extension localized in the upper crust and the overall crustal thinning. This suggests that continental deformation in the Orphan Basin involved, in addition to the documented Jurassic and Early Cretaceous rifting, an earlier brittle rift phase which is unidentifiable in seismic data and a depth-dependent thinning of the crust driven by localized lower crust ductile flow.
Condylar volume and surface in Caucasian young adult subjects (2010)

These data from temporomandibular joints of patients without pain or clinical dysfunction might serve as examples of normal TMJ's in the general population not seeking orthodontic care.
Gigacycle Fatigue Behaviour of Sintered WC-Co Hardmetals Investigated by Ultrasonic Resonance Testing (2015)

Hardmetals, manufactured from powders by pressing and sintering, are the most important tool materials in service today. In many applications, such as milling or percussion drilling, they are subjected to fatigue with considerable loading cycle numbers. In the present study, the fatigue behaviour of hardmetals in push-pull loading was investigated up to N max = 10 10 using ultrasonic resonance fatigue testing. It showed that with all hardmetal grades investigated there is no fatigue “limit”, i.e. a horizontal branch of the S-N curve, but a consistent drop of the curve up to maximum N. Crack initiation was found to occur predominantly microstructure-controlled, as compared to defect controlled as typical for powder metallurgy tool steels.Keywords: gigacycle fatigue, WC-Co hardmetals, ultrasonic fatigue testing, fatigue limit
Ultra-Rapid Microwave/Variable Pressure-Induced Histoprocessing: Description of a New Tissue Processor (1998)

AbstractWe describe a new method of ultra-rapid histoprocessing that reduces the processing times for needle and endoscopic biopsies to 30 min and that of other surgical biopsy tissue blocks of up to 4 mm thick to 120 min. The MicroMED U R M Histoprocessor, which combines microwave irradiation with precise computer control of power, time, temperature, vacuum, and pressure, when used with a 1-step dehydrating/clearing reagent, consistently produces rapidly processed tissues with optimal cytomorphology and improved tissue sectioning properties. Staining properties are excellent with no deleterious effects on routine staining, histochemistry, or immunohistochemistry. This new processing technique represents a major change from conventional tissue processing and eliminates the use of hazardous reagents such as xylene. The ease of application and speed of this technique can significantly reduce turnaround times in diagnostic laboratories. (The J Histotechnol 21:219–224, 1998)Keywords: microwave irradiationpressureone-step dehydrationclearingultra-rapid histoprocessingvacuum
A Laser-Diode-Pumped Widely Tunable Single-Longitude-Mode Tm:YAP Laser at Room Temperature (2007)

A laser-diode-pumped widely tunable single-longitude-mode Tm:YAP laser in 2 μm eye-safe region is built. Continuous tunable range from 1899 nm to 2025 nm is achieved with the maximum laser output power of 225 mW at 1989 nm. In addition, the Tm:YAP laser operating under multimode and single-mode conditions is discussed.
Efficient Hybrid Solar Cells Based on Solution Processed Mesoporous TiO2/Tin(II) Sulfide Heterojunctions (2018)

Tin monosulfide (SnS) is emerging as a promising absorber material for the development of low-cost, solution-processable solar cells. Herein, we present a straightforward, solution-based route for the preparation of tin monosulfide (SnS) films employing a green solvent, namely, tetrahydrofuran (THF). We show that the surface coverage and the morphology of the SnS films can be tuned by modification of the precursor solution composition and film deposition conditions. Furthermore, we explore the effect of a PEDOT:PSS interlayer and fabricate solar cells based on the following architecture: FTO/planar-TiO2/mesoporous-TiO2/SnS/P3HT/PEDOT:PSS/Ag. Devices based on this architecture are shown to exhibit power conversion efficiencies (PCEs) of 3.0%, thus demonstrating the potential of our method for the development of low-cost and environmentally friendly solar cells.
The ωσ method: A new contactless comparison method for measuring electrical conductivity of nonferromagnetic conductors (1997)

A novel, very simple, eddy current method for measuring the electrical conductivity of nonferromagnetic conductors is described. This method is relative, i.e., we measure the ratio of conductivities of two samples of the same shape and size (this shape and size may be arbitrary). For one of them, conductivity is known, this is the reference sample, whereas the conductivity of the other is unknown and it is to be determined. Consequently, in this method it is necessary to have a reference sample of known conductivity. On the other hand, in this method no other calibration is necessary; the ratio of two conductivities we obtain directly as the ratio of two frequencies, without any calibration. The principle of this method is as follows: It turns out, based on Maxwell’s equations, that if we have a coil through which a sinusoidal current of an angular frequency ω flows and in whose magnetic field a given conductive, nonferromagnetic sample is placed, the effective inductance (i.e., the ratio of the reactive part of the impedance to the frequency ω) depends on ω and on the conductivity of the sample σ only through their product ωσ. Therefore, if it is found that with a sample of conductivity σ 1 at frequency ω1 the effective inductance is equal to that of a sample with conductivity σ 2 and frequency ω2 (the samples being of the same shape and size, both nonferromagnetic, and both placed in the same position relative to the coil), this means that equality ω1σ1=ω2σ2 is valid. Hence, if σ1 is known and σ2 is unknown, σ2 can be calculated.
Transformation semi-automatique d'images aériennes à haute résolution en cartes de vigueur de la vigne à l'échelle intra-parcellaire (2007)

International audience
MP03-10 PILOT STUDY EVALUATING PSMA-TARGETED 18 F-DCFPYL PET/CT IN PATIENTS WITH METASTATIC CLEAR CELL RENAL CELL CARCINOMA (2016)

body mass index, Karnofsky performance status (KPS), Charlson Comorbidity Index, anemia, neutrophilia, neutrophil-to-lymphocyte ratio (NLR), thrombocytosis, hypercalcemia, T and N stages, tumor size, grade, subtype, sarcomatoid feature, tumor thrombus, number and location of metastasis, lymph node metastasis (supradiaphragmatic vs. subdiaphragmatic), cytoreductive nephrectomy, time from diagnosis to TT, number of TT lines, and tumor response following TT. Multivariate Cox-regression models were used to quantify the effect of covariates on CSS.
An analytical approach to model adaptive video streaming and delivery (2010)

An efficient and practical technique for robust and scalable distribution of multimedia content is the key to satisfy a large group of peers' needs endowed with limited network resources. Given a video source, a group of intended destination peers and heterogeneous network resources, the challenge is to distribute the content among these peers to ensure the best quality of experience using Peer-to-Peer (P2P) paradigm. In the literature, there exists some promising solutions to address this issue; however, without an optimal solution it is hard to judge the efficiency of the existing protocols. In this paper, we present a mathematical model to represent an adaptive video streaming architecture for peer-to-peer networks and social networking. The model encompasses multiple-parent resource contribution in terms of bandwidth and CPU power. We also present a performance analysis which illustrates the trade-offs in service fairness and system efficiency.
Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility (2020)

Localization of the N-methyl-D-aspartate type glutamate receptor (NMDAR) to dendritic spines is essential for excitatory synaptic transmission and plasticity. Rather than remaining trapped at synaptic sites, NMDA receptors undergo constant cycling into and out of the postsynaptic density. Receptor movement is constrained by protein-protein interactions with both the intracellular and extracellular domains of the NMDAR. The role of extracellular interactions on the mobility of the NMDAR is poorly understood. Here we demonstrate that the positive surface charge of the hinge region of the N-terminal domain in the GluN1 subunit of the NMDAR is required to maintain NMDARs at dendritic spine synapses and mediates the direct extracellular interaction with a negatively charged phospho-tyrosine on the receptor tyrosine kinase EphB2. Loss of the EphB-NMDAR interaction by either mutating GluN1 or knocking down endogenous EphB2 increases NMDAR mobility. These findings begin to define a mechanism for extracellular interactions mediated by charged domains.
An Efficient Centroid-Based Routing Protocol for Energy Management in WSN-Assisted IoT (2017)

Wireless sensor networks (WSNs) distribute hundreds to thousands of inexpensive microsensor nodes in their regions, and these nodes are important parts of Internet of Things (IoT). In WSN-assisted IoT, the nodes are resource constrained in many ways, such as storage resources, computing resources, energy resources, and so on. Robust routing protocols are required to maintain a long network lifetime and achieve higher energy utilization. In this paper, we propose a new energy-efficient centroid-based routing protocol (EECRP) for WSN-assisted IoT to improve the performance of the network. The proposed EECRP includes three key parts: a new distributed cluster formation technique that enables the self-organization of local nodes, a new series of algorithms for adapting clusters and rotating the cluster head based on the centroid position to evenly distribute the energy load among all sensor nodes, and a new mechanism to reduce the energy consumption for long-distance communications. In particular, the residual energy of nodes is considered in EECRP for calculating the centroid's position. Our simulation results indicate that EECRP performs better than LEACH, LEACH-C, and GEEC. In addition, EECRP is suitable for networks that require a long lifetime and whose base station (BS) is located in the network.
PLANT TRANSCRIPTION FACTOR STUDIES (1998)

Major advances have been made in understanding the role of transcription factors in gene expression in yeast, Drosophila, and man. Transcription factor modification, synergistic events, protein-protein interactions, and chromatin structure have been successfully integrated into transcription factor studies in these organisms. While many putative transcription factors have been isolated from plants, most of them are only poorly characterized. This review summarizes examples where molecular biological techniques have been successfully employed to study plant transcription factors. The functional analysis of transcription factors is described as well as techniques for studying the interactions of transcription factors with other proteins and with DNA.
Efficient Gene Delivery and Selective Transduction of Glial Cells in the Mammalian Brain by AAV Serotypes Isolated From Nonhuman Primates (2009)

Adeno-associated viral (AAV) vectors have become the primary delivery agent for somatic gene transfer into the central nervous system (CNS). To date, AAV-mediated gene delivery to the CNS is based on serotypes 1-9, with efficient gene transfer to neurons only-selective and widespread transduction of glial cells have not been observed. Recently, additional endogenous AAVs have been isolated from nonhuman primate tissues. In this study, transduction obtained with AAV serotypes bb2, cy5, rh20, rh39, and rh43 was compared to that obtained with AAV8, another nonhuman primate isolate previously shown to perform well in mammalian brain. Titer-matched vectors encoding the enhanced green fluorescent protein (EGFP) reporter, driven by the constitutive CAG promoter, were injected into the hippocampus, striatum, or substantia nigra (SN) of adult rats. More widespread neuronal transduction was observed following infusion of cy5, rh20, and rh39 than observed with AAV8. Of interest, preferential transduction of astrocytes was observed with rh43. To optimize glial transduction, vector stocks driven by cell-specific promoters were generated-widespread and targeted transduction of astrocytes and oligodendrocytes was observed using rh43 and AAV8, driven by the glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP) promoters, expanding the utility of AAV for modeling and treating diseases involving glial cell pathology.
Actions of the Judicial Commission of the International Committee on Systematic Bacteriology on Requests for Opinions Published in 1982 (1984)

Three requests for Opinions were published in 1982. Two of these, one requesting rejection of the name Nocardia farcinica and one requesting substitution of the family name Escherichiaceae for Enterobacteriaceae, have been denied. The third, requesting confirmation of types designated in the Approved Lists as nomenclatural types, has been awarded.
FPGA-based transformable computers for fast digital signal processing (2002)

FPGA-based computing systems provide a feasible and cost-effective platform for implementing fast parallel arithmetic circuits for digital signal and image processing. This paper reports the results obtained from embedding a highly parallel convolution algorithm on an FPGA-based computer. Such a computer is intended to serve as a transformable co-processor for a standard microprocessor system. However, the transformable co-processor is reconfigurable and is capable of exploiting the concurrency of computations more than the sequential microprocessor. Our experiments show that a significant gain in speed can be achieved by using the transformable coprocessor. We present an example of performing a sequence of (independent) 16-point convolutions on 8-bit data, and show that the speed factor improves significantly as the number of convolutions to be performed increases.
A Bipartite Nuclear Localization Signal Is Required for p53 Nuclear Import Regulated by a Carboxyl-terminal Domain (1999)

Abnormal p53 cellular localization has been considered to be one of the mechanisms that could inactivate p53 function. To understand the regulation of p53 cellular trafficking, we have previously identified two p53 domains involved in its localization. A basic domain, Lys(305)-Arg(306), is required for p53 nuclear import, and a carboxyl-terminal domain, namely the cytoplasmic sequestration domain (CSD) from residues 326-355, could block the nuclear import of Lys(305) or Arg(306) mutated p53. To characterize further the function of these two domains, we demonstrate in this report that the previously described major nuclear localization signal works together with Lys(305)-Arg(306) to form a bipartite and functional nuclear localization sequence (NLS) for p53 nuclear import. The CSD could block the binding of p53 to the NLS receptor, importin alpha, and reduce the efficiency of p53 nuclear import in MCF-7, H1299, and Saos-2 cells. The blocking effect of the CSD is not due to the enhancement of nuclear export or oligomerization of the p53. These results indicate that the CSD can regulate p53 nuclear import by controlling access of the NLS to importin alpha binding.
An efficient implementation of a micro virtual machine (2018)

Implementing a managed language efficiently is hard, and it is becoming more difficult as the complexity of both language-level design and machines is increasing. To make things worse, current approaches to language implementations make them prone to inefficiency as well. A high-quality monolithic language implementation demands extensive expertise and resources, but most language implementers do not have those available so their implementations suffer from poor performance. Alternatively, implementers may build on existing frameworks. However, the back-end frameworks often offer abstractions that are mismatched to the language, which either bounces back the complexity to the implementers or results in inefficiency. Want et al. proposed micro virtual machines as a solution to address this issue. Micro VMs are explicitly minimal and efficient. Micro VMs support high-performance implementation of managed languages by providing key abstractions, i.e. code execution, garbage collection, and concurrency. The abstractions are neutral across client languages, and general and flexible to different implementation strategies. These constraints impose interesting challenges on a micro VM implementation. Prior to this work, no attempt had been made to efficiently implement a micro VM. My thesis is that key abstractions provided by a micro virtual machine can be implemented efficiently to support client languages. By exploring the efficient implementation of micro virtual machines, we present a concrete implementation, Zebu VM, which implements the Mu micro VM specification. The thesis addresses three critical designs in Zebu, each mapping to a key abstraction that micro virtual machines provide, and establishes their efficiency: 1) demonstrating the benefits of utilizing a modern language that focuses on safety to implement a high performance garbage collector, 2) analysing the design space of yieldpoint mechanism for thread synchronization, and 3) building a micro compiler under the specific constraints imposed by micro virtual machines, i.e. minimalism, efficiency and flexibility. This thesis is a proof of concept and an initial proof of performance to establish micro virtual machines as an efficient substrate for managed language implementation. It encourages the approach of building language implementations with micro virtual machines, and reinforces the hope that Mu will be a suitable back-end target. The thesis discusses the efficient implementation for micro virtual machines, but illustrates broader topics useful in general virtual machine design and construction.
Leveraging agricultural total factor productivity growth for productive, sustainable and resilient farming systems (2019)

Increased global agricultural output since the 1990s has been largely driven by innovations that raised the use efficiency of labor, land, capital and other inputs—referred to as total factor productivity (TFP) growth. Yet, debates over the future of farming still weigh heavily on models of agricultural land use and socioecological tradeoffs along traditional (partial-factor productivity) growth paths of ‘intensification’ or ‘extensification’. Overlooking the role of TFP in the evolution of global agriculture not only obscures the changing drivers of productivity growth but misses vital linkages with agricultural sustainability and farming system resilience. We describe two pathways for growth—technology-based and ecosystem-based—and link these in a heuristic framework that emphasizes sustainability and resilience outcomes in farming systems. Interdisciplinary research is urgently needed to empirically examine the dynamic interplay of TFP growth, farming system sustainability and resilience. Such insights are needed to transform TFP growth as metric into actionable efforts on farms and beyond.
ChemInform Abstract: Homogeneous Organometallic Chemistry of Methane (2013)

Abstract Review: 210 refs.
The Corticotropin-Releasing Hormone Stimulation Test:A Possible Aid in the Evaluation of Patients with Adrenal Insufficiency* (1984)

Ten patients with adrenal insufficiency receiving chronic glucocorticoid therapy were studied. All had subnormal plasma cortisol responses to ovine corticotropin-releasing hormone ( CRH ) (1 microgram/kg as an iv bolus) 12-60 h after discontinuation of steroid treatment. Plasma ACTH responses to CRH fell into three different patterns. The first three patients with primary adrenal insufficiency had high basal ACTH levels and augmented ACTH responses to CRH . A fourth such patient, however, treated with pharmacologic doses of prednisone, had a low normal ACTH response. Patients with secondary adrenal insufficiency had either low basal ACTH levels and diminished responses to CRH or low basal ACTH values but prolonged and augmented plasma ACTH responses to CRH with a delayed peak. We postulate that the group of patients with the former pattern have pituitary gland destruction whereas the patients with the latter pattern have hypothalamic CRH deficiency. Thus, CRH may be useful in differentiating between hypothalamic and pituitary causes of adrenal insufficiency.