gebhart/patrepeval huggingface dataset:
A User Authentication Scheme Based on Identity-bits Commitment for Wireless Sensor Networks (2010)

Wireless sensor networks have received a great attention since they emerged as new ways of communicating and distributing information in wireless network. However the security aspect of wireless sensor network remains an issue, namely authentication, key management and secure localization. Since the communication of wireless sensor is on broadcast basis, researchers are focusing on how to design an efficient authentication scheme since the data might lost during the transmission and this is crucial for entity authentication prior the actual communication. Entity or user authenticity is important to avoid forgery and replay attack. This paper will focus on authentication by investigating three authentication schemes based on user authentication for Wireless Sensor Network. We identify their weakness and we finally introduce a new scheme which is based on identity-bits commitment for authentication that overcomes problems identified in studied schemes. A basic security analysis is followed to support the strength of the scheme in a real deployment.
Experimental Analysis of Short-Circuit Scenarios Applied to Silicon-Graphite/Nickel-Rich Lithium-Ion Batteries (2022)

Short-circuit incidents pose a severe safety threat to lithium-ion batteries during lifetime. Understanding the underlying electrochemical behavior can help to mitigate safety risks. The electrochemically-caused rate-limiting behavior is analyzed using a quasi-isothermal test-bench, where external and local short-circuit conditions are applied to single-layered pouch cells (&lt;50 mAh). The cell voltage, the heat generation rate, and either the short-circuit current or a local electrical potential are measured and used to characterize the short-circuit intensity. The results of 35 custom-built silicon-graphite SiC/NCA and SiC/NMC-811 cells with 2.5 wt.-% silicon are benchmarked to previously studied graphite G/NMC-111 cells. An additional current plateau appears for the silicon-graphite/nickel-rich cells, which is ascribed to the anode-limited electrode balancing. At a maximum, 29% of the total dissipated heat is caused during over-discharge. The effect of cyclic aging on the impact of the short-circuit behavior is investigated with aged single-layered pouch cells (SoH &lt; 80%), which revealed nearly the same levels of over-discharge as non-aged cells. A lithium reference electrode is used to visualize polarization effects in the anode during ESCs and to evaluate the onset of copper dissolution (&gt;3.2 V vs Li/Li + ), which could be estimated up to 20% of the negative current collector mass.
A Fluorescent Chemosensor for Sodium Based on Photoinduced Electron Transfer (2002)

A new optical sensor suitable for practical measurement of sodium in serum and whole blood samples is described. The optical sensor is based on a novel PET (photoinduced electron transfer) fluoroionophore immobilized in a hydrophilic polymer layer. The design concept of the fluoroionophore follows the receptor-spacer-fluorophore approach to sensor design using intramolecular PET-based signal transduction. Key to the development of this sensor is the identification of a nitrogen-containing, sodium-binding ionophore, coupled with a fluorophore having the correct spectral and electron-accepting properties. The slope of the sensor is approximately 0.5%/mM in the typical clinically significant range of 120-160 mM. This sensor has been implemented into a disposable cartridge, used for a commercially available critical care analyzer (Roche OPTI CCA) with precision better than +/- 1 mM (1 SD). The sensor displays excellent stability against hydrolysis and oxidation, leading to slope changes <5% after 9 months wet storage at 30 degrees C. On the basis of this design concept, fluoroionophores for other cations such as potassium, calcium and magnesium can be prepared by substitution of the ionophore.
Sample Chemical Staining and Latest Generation SEM Imaging—Characterizing Process Robustness in Semiconductor Manufacturing (2016)

Abstract Physical characterization of individual process steps and their interaction with other processes is a key element during development as well as manufacturing of semiconductor technology. This paper presents a number of examples that illustrate the usefulness of the combination of sample wet-chemical staining techniques with the latest generation SEM imaging capabilities. The examples show how sample preparation and imaging conditions have to be tailored to the specific needs. The combination of application-tailored chemical decoration with high-resolution material contrast SEM imaging has proven to be a powerful technique for the characterization of manufacturing process steps. Only with the novel imaging modes available in the latest generation SEM instruments, it became possible to perform investigations with fast turnaround times and on large sample areas.
ORIGINAL ARTICLE: The Association of Apoprotien E Polymorphisms with Recurrent Pregnancy Loss (2008)

Apo E4 polymorphism may contribute to the thrombophilic risk factors contributing to recurrent pregnancy loss.
Raman spectroscopy: A rapid method to assess the effects of pasture feeding on the nutritional quality of butter (2020)

The animal diet is a critical variable affecting the composition and functionality of dairy products. As "Grass-Fed" labeling becomes more prominent on the market, rapid and label-free methods for verification of feeding systems are required. This work proposes the use of Raman spectroscopy to study the effects of 3 different experimental cow feeding systems-perennial ryegrass pasture, perennial ryegrass with white clover pasture, and an indoor total mixed ration diet (TMR)-on the nutritional quality of sweet cream butter. The results demonstrate that Raman spectroscopy coupled with multivariate analysis is a promising approach to distinguish butter derived from pasture or conventional TMR feeding systems. A Pearson correlation analysis confirmed high positive correlations between the spectral bin at 1,657 cm<sup>-1</sup>, ascribed to the stretching vibrations of C=C bonds, and concentrations of α-linolenic acid and conjugated linolenic acid (CLA) in butter, and in general with the concentration of n-3 and n-3+CLA fatty acids and polyunsaturated fatty acids in the samples. The yellow color indicative of the presence of carotenoids in butter, which has previously been suggested as a biomarker of pasture or "Grass-Fed" feeding, was also positively correlated with the data obtained from the Raman spectra. Raman spectroscopy could also be used to accurately predict indicators of the nutritional quality of butter, such as the thrombogenic index, which showed a strong negative correlation with the spectral bin at 3,023 cm<sup>-1</sup>.
Intracranial Haemorrhage in Haemophilia Patients Is Still an Open Issue: The Final Results of the Italian EMO.REC Registry (2022)

Background: Intracranial hemorrhage (ICH) is a highly serious event in patients with haemophilia (PWH) which leads to disability and in some cases to death. ICH occurs among all ages but is particularly frequent in newborns. Aim: The primary aim was to assess the incidence and mortality due to ICH in an Italian population of PWH. Secondary aims were to evaluate the risk factors for ICH, the role of prophylaxis, and the clinical management of patients presenting ICH. Methods: A retrospective-prospective registry was established in the network of the Italian Association of Haemophilia Centers to collect all ICHs in PWH from 2009 to 2019 reporting clinical features, treatments, and outcomes. Results: Forty-six ICHs were collected from 13 Centers. The ICHs occurred in 15 children (10 < 2 years), and in 31 adults, 45.2% of them with mild hemophilia. Overall, 60.9% patients had severe haemophilia (15/15 children). Overall ICH incidence (×1000 person/year) was 0.360 (0.270−0.480 95% CI), higher in children <2 years, 1.995 (1.110−3.442 95% CI). Only 7/46 patients, all with severe haemophilia, had received a prophylactic regimen before the ICH, none with mild. Inhibitors were present in 10.9% of patients. In adult PWHs 17/31 suffered from hypertension; 85.7% of the mild subjects and 29.4% of the moderate/severe ones (p < 0.05). ICH was spontaneous in the 69.6% with lower rate in children (46.7%). Surgery was required in 21/46 patients for cerebral hematoma evacuation. Treatment with coagulation factor concentrates for at least three weeks was needed in 76.7% of cases. ICH was fatal in 30.4% of the cases. Of the survivors, 50.0% became permanently disabled. Only one-third of adult patients received long term prophylaxis after the acute treatment. Conclusion: The results from our Registry confirm the still high incidence of ICH in infants <2 years and in adults, particularly in mild PWHs presenting hypertension and its unfavorable outcomes. The majority of PWHs were treated on-demand before ICH occurred, suggesting the important role of prophylaxis in preventing such life-threatening bleeding.
Effect of disinfectant residual, pH, and temperature on microbial abundance in disinfected drinking water distribution systems (2020)

This work demonstrates insights gained from monitoring absolute microbial abundance in full-scale disinfected drinking water distribution systems and lays a foundation for statistical approaches that could provide a basis for applying these tools.
Clinical Use of Diuretics in Heart Failure, Cirrhosis, and Nephrotic Syndrome (2015)

Diuretics play significant role in pharmacology and treatment options in medicine. This paper aims to review and evaluate the clinical use of diuretics in conditions that lead to fluid overload in the body such as cardiac failure, cirrhosis, and nephrotic syndrome. To know the principles of treatment it is essential to understand the underlying pathophysiological mechanisms that cause the need of diuresis in the human body. Various classes of diuretics exist, each having a unique mode of action. A systemic approach for management is recommended based on the current guidelines, starting from thiazides and proceeding to loop diuretics. The first condition for discussion in the paper is cardiac failure. Treatment of ascites in liver cirrhosis with spironolactone as the primary agent is highlighted with further therapeutic options. Lastly, management choices for nephrotic syndrome are discussed and recommended beginning from basic sodium restriction to combined diuretic therapies. Major side effects are discussed.
Flow Through an Outlet Cannula of a Rotary Ventricular Assist Device (2002)

Rotary ventricular assist devices (VADs) are primarily used during surgery and short-term postoperative assistance. There are issues involving the use of rotary VADs including the behavior of flow emanating from the assist device which might induce flow irregularities that could potentially lead to stroke or cerebrovascular accident. An in vitro flow visualization study using particle image velocimetry was conducted to evaluate flow fields at the bend of outlet cannulae with angles ranging from 30 degrees to 75 degrees. A multiple disk centrifugal blood pump produced steady, laminar flow fields at the outlet. Flow fields at the bend of each cannula demonstrated the development of a boundary layer along the inner wall and shift of fluid momentum to the outer wall. Stagnant zones along the inner wall were prevalent for each cannula and increased in severity with increasing angle. The outlet flow fields of rotary VADs have the potential to produce thrombus, feasibly leading to thromboembolisms should the bend angle of the outlet cannula be acute enough. Therefore, the placement of the outlet cannula or conduit should be taken into consideration during implantation.
Potent Immunoregulatory Effects ofSalmonella typhiFlagella on Antigenic Stimulation of Human Peripheral Blood Mononuclear Cells (1999)

A key function of monocytes/macrophages (Mphi) is to present antigens to T cells. However, upon interaction with bacteria, Mphi lose their ability to effectively present soluble antigens. This functional loss was associated with alterations in the expression of adhesion molecules and CD14 and a reduction in the uptake of soluble antigen. Recently, we have demonstrated that Salmonella typhi flagella (STF) markedly decrease CD14 expression and are potent inducers of proinflammatory cytokine production by human peripheral blood mononuclear cells (hPBMC). In order to determine whether S. typhi and soluble STF also alter the ability of Mphi to activate T cells to proliferate to antigens and mitogens, hPBMC were cultured in the presence of tetanus toxoid (TT) or phytohemagglutinin (PHA) and either killed whole-cell S. typhi or purified STF protein. Both whole-cell S. typhi and STF suppressed proliferation to PHA and TT. This decreased proliferation was not a result of increased Mphi production of nitric oxide, prostaglandin E2, or oxygen radicals or the release of interleukin-1beta, tumor necrosis factor alpha, interleukin-6, or interleukin-10 following exposure to STF. However, the ability to take up soluble antigen, as determined by fluorescein isothiocyanate-labeled dextran uptake, was reduced in cells cultured with STF. Moreover, there was a dramatic reduction in the expression of CD54 on Mphi after exposure to STF. These results indicate that whole-cell S. typhi and STF have the ability to alter in vitro proliferation to soluble antigens and mitogens by affecting Mphi function.
Latency and energy aware value prediction for high-frequency processors (2002)

This work addresses the issues of access latency and energy consumption in value predictor design for high-frequency, wide-issue microprocessors. Previous value prediction research allows for generous assumptions regarding table configurations and access conditions, while ignoring prediction latencies and energy issues. However, the latency of a high-performance value predictor cannot always be completely hidden by the early stages of the instruction pipeline as previously assumed, and it causes noticeable performance degradation versus unconstrained value prediction. This paper describes and compares several variations of basic value prediction methods: at fetch, post-decode, and decoupled.The performance of at-fetch and post-decode value predictors is limited by the high access latency of accurate predictor configurations. Decoupled value prediction excels at overcoming the high-frequency table access constraints by placing completion-time predictions into a separate and easily accessible storage. However, it has high energy requirements. We study a value prediction approach that combines the latency-friendly approach of decoupled value prediction with a more energy-efficient implementation. The traditional PC-indexed prediction tables are removed and replaced by a queue of prediction traces. This latency and energy aware method of maintaining and distributing speculated values leads to a 58%-95% reduction in value predictor energy consumption versus known value prediction techniques while still maintaining high performance.
Confocal mimics hematoxylin and eosin: recent technical development in translation (Conference Presentation) (2020)

There us a significant need for point of care pathology technologies that provide microscopic resolution without the processing that is typically required. 20,000,000 biopsies per year in the USA each present a week delay in cancer care while they are processed and analyzed. Bedside confocal microscopy offers an alternative but has typically been difficult to perform due to the irregularity of surgical specimens and reflectance artifact. The sample irregularity makes it hard to put the correct plane of tissue in the conjugate focal plane and the reflectance artifact that arises from the glass/water interface at the window surface onto which the sample is pressed, gives the appearance of tissue outside the specimen (where there is no tissue, false positive for tissue). We present newly developed computational and electromechanical solutions to these problems and analysis of specimens under our clinical research study.
Semiempirical studies of the mechanism of models for the N-hydroxylation of amines by cytochrome P450 (2009)

The oxidation of amines to their corresponding N-hydroxylamines was investigated by the semiempirical mndo and mindo/3 methods. The reaction for which the calculations were performed is O(1S) + CH3NH2 → CH3NHOH. Regions of the potential energy surface corresponding to various possible mechanisms were characterized. The results of mindo/3 and mndo qualitatively agree in almost all respects. Direct insertion of the oxygen into the N-H bond appears to be ruled out. Hydrogen abstraction by the oxygen atom, followed by recombination of the OH species with the nitrogen, is an unlikely pathway. The results strongly indicate that the formation of an N-oxide intermediate would occur. This N-oxide would rearrange to the hydroxylamine. The solvent assisted rearrangement of N-oxide is modeled and shown to substantially lower the barrier to rearrangement.
“USE IN WELL-VENTILATED AREA”? (1999)

The warning “Use in a Well-Ventilated Area” often found on material safety data sheets (MSDSs) or equipment specifications is not adequate. This admonition provides no specific information or guidance that would allow safety, industrial hygiene, or facility engineering functions to anticipate, design, or achieve a workplace that will protect occupants. This article presents a method for manufacturers of equipment, consumer goods, or industrial process systems to enhance product stewardship by quantifying the total volatile emission rates of a unit of equipment and then specifying the number of total air changes required per unit to assure a workplace atmosphere below acceptable inhalation exposure guidelines or regulatory limits. It is proposed that manufacturers and distributors of equipment, consumer goods, or industrial process units provide MSDS information specifying the number of air changes per hour of uncontaminated air that would be required for each device, consumer product, or piece of equipment to achieve adequate ventilation.
An Interface for Annotating Science Questions (2018)

Michael Boratko, Harshit Padigela, Divyendra Mikkilineni, Pritish Yuvraj, Rajarshi Das, Andrew McCallum, Maria Chang, Achille Fokoue, Pavan Kapanipathi, Nicholas Mattei, Ryan Musa, Kartik Talamadupula, Michael Witbrock. Proceedings of the 2018 Conference on Empirical Methods in Natural Language Processing: System Demonstrations. 2018.
Comparison of Inlet Geometry in Microfluidic Cell Affinity Chromatography (2011)

Cell separation based on microfluidic affinity chromatography is a widely used methodology in cell analysis research when rapid separations with high purity are needed. Several successful examples have been reported with high separation efficiency and purity; however, cell capture at the inlet area and inlet design have not been extensively described or studied. The most common inlets-used to connect the microfluidic chip to pumps, tubing, etc.-are vertical (top-loading) inlets and parallel (in-line) inlets. In this work, we investigated the cell capture behavior near the affinity chip inlet area and compared the different performances of vertical inlet devices and parallel inlet devices. Vertical inlet devices showed significant cell capture capability near the inlet area, which led to the formation of cell blockages as the separation progressed. Cell density near the inlet area was much higher than that in the remaining channel, whereas for parallel inlet chips cell density at the inlet area was similar to that in the rest of the channel. In this paper, we discuss the effects of inlet type on chip fabrication, nonspecific binding, cell capture efficiency, and separation purity. We also discuss the possibility of using vertical inlets in negative-selection separations. Our findings show that inlet design is critical and must be considered when fabricating cell affinity microfluidic devices.
Modeling the Dynamic Variability Induced by Charged Traps in a Bilayer Gate Oxide (2014)

In this paper, we revisit the classic single layer defect centric model (DCM), largely used in reliability studies, in the more realistic case of bilayer gate oxide transistors integrating an interface layer and a high-K dielectric. The Monte Carlo method and 3-D electrostatic simulations are used to determine the impact of the traps present in both layers on the Vt of transistors. It is proved that the DCM is able to capture the trap-induced variability of bilayer transistors but with effective model parameters, which have no more a true physical meaning as in the case of the single layer gate oxide. An extended DCM, accounting for a two trap distributions, is then proposed to better explain the degradation measured on bilayer transistors. Finally, this extended DCM finds another application in the evaluation of the bias temperature instability-induced variability of static RAM cells.
MoDLE: high-performance stochastic modeling of DNA loop extrusion interactions (2022)

DNA loop extrusion emerges as a key process establishing genome structure and function. We introduce MoDLE, a computational tool for fast, stochastic modeling of molecular contacts from DNA loop extrusion capable of simulating realistic contact patterns genome wide in a few minutes. MoDLE accurately simulates contact maps in concordance with existing molecular dynamics approaches and with Micro-C data and does so orders of magnitude faster than existing approaches. MoDLE runs efficiently on machines ranging from laptops to high performance computing clusters and opens up for exploratory and predictive modeling of 3D genome structure in a wide range of settings.
Effects of pain, sedation and delirium monitoring on clinical and economic outcome: A retrospective study (2020)

clinicaltrials.gov NCT02265263, Registered 15 October 2014.
A numerical simulation model for multi-scale flow in tight oil reservoirs (2017)

A discrete fracture model for multi-scale flow in large-scale fractured tight oil reservoirs is proposed considering the compressibility of reservoir rock and fluid, and the non-linear flow in the tight matrix. Validation of the model is performed, followed by the field application of the model. The two-point flux-approximation scheme is adopted in the model to calculate conductivity, and small grids at the fracture intersections are eliminated by the “star-delta” transformation method to improve the computational stability. The fully implicit discretization scheme is performed on the temporal domain. Automatic differentiation technique which can improve model establishment efficiency and computational accuracy is applied in the model to solve the numerical model. The model is validated with the simulation results of Eclipse and the historical production data of a long fractured horizontal well in a tight oil reservoir in Xinjiang oilfield. Simulation results of a field-scale reservoir show that the model proposed can simulate reservoirs with large-scale complex fracture systems; well productivity is positively correlated with the scale of the stimulated reservoir volume, and the difference in planar fracture density and fracture connectivity are proved to be the key factors that lead to the heterogeneous distribution of remaining oil in tight oil reservoirs.