gebhart/patrepeval huggingface dataset:
System Considerations for Millimeter Wave Satellite Communications (1966)

The feasibility of instrumenting earth-space and satellite-satellite links is analyzed for frequencies between 30 and 100 GHz. Propagation and orbital parameters are considered, and data (mainly from computer programs) are presented on time-in-view for various ground locations, mutual visibility time between two orbiting satellites, effects of limiting the antenna elevation angle excursion, antenna pointing considerations, antenna types and gain/beamwidth limitations, and available ground station facilities. Orbits range from 100 to 19,357 nautical miles (nmi) altitude (synchronous) and from O° (equatorial) to 90° (polar) inclination angles. System design parameters are tabulated for typical links, including transmitter power requirements, doppler shifts, tradeoffs in bandwidth, range, power, and antenna gains. The millimeter wave equipment situation is reviewed because any space system will be limited by the state-of-the-art in hardware and techniques, including performance, reliability, weight, space, and power requirements.
Decreased Arachidonate Metabolism in Mouse Peritoneal Macrophages after Foam Cell Transformation with Oxidized Low-Density Lipoproteins1 (1992)

Oxidized low density lipoproteins (LDL) are now considered to be one of the atherogenic lipoproteins in vivo and to play an important role in the pathogenesis of atherosclerosis. We previously demonstrated in mouse peritoneal macrophages that oxidized LDL stimulated prostaglandin (PG) E2 synthesis when incorporated into the cells [Yokode, M. et al. (1988) J. Clin. Invest. 81, 720-729]. In this study, we investigated arachidonate metabolism in macrophages after foam cell transformation. The cells were incubated with 100 micrograms/ml of oxidized LDL for 18 h, then stimulated with zymosan. Lipid-enriched macrophages which had taken up oxidized LDL produced much less eicosanoids, such as PGE2, 6-keto-PGF1 alpha, and leukotriene C4 than control cells. After labeling of the cells with [14C]arachidonic acid, they were stimulated with zymosan and the phospholipase activity was determined. The activity of lipid-enriched cells was about two-thirds of that of control cells. Then we investigated the fatty acid composition of their phospholipid fraction to clarify arachidonic acid content and mobilization. Percent of arachidonic acid of lipid-enriched cells decreased and less arachidonic acid mobilization was observed after stimulation with zymosan. These data suggest that impaired arachidonate metabolism in lipid-enriched macrophages can be explained by their decreased phospholipase activity and changes in their fatty acid composition.
Cascade Reactions Involving Formal [2+2] Thermal Cycloadditions: Total Synthesis of Artochamins F, H, I, and J (2007)

Flexibel zum Erfolg: Die Totalsynthesen der Artochamine F (1), H (2), I (3) und J (4; siehe Schema) gelangen mithilfe einer flexiblen Strategie, zu der eine Kaskadensequenz aus zwei simultanen [3,3]-sigmatropen Umlagerungen und einer ungewöhnlichen intramolekularen thermischen [2+2]-Cycloaddition zwischen einem elektronenreichen Stilben und einer Prenylgruppe gehört. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2007/z702363_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A holistic perspective on hearing loss: first quality-of-life questionnaire (HL-QOL) for people with hearing loss based on the international classification of functioning, disability, and health (2023)

Introduction To date, there is no quality-of-life questionnaire for people with hearing loss based on a multidisciplinary framework. Therefore, this study aimed to develop and validate a comprehensive assessment tool that addresses quality of life in people with hearing loss who use a cochlear implant based on the International Classification of Functioning, Disability, and Health (ICF). Methods In a first step, the Quality of Life in People with Hearing Loss Questionnaire (HL-QoL) was developed and tested for face validity. In a second step, the HL-QoL was evaluated and validated. In a third step, the HL-QoL was finalized based on the outcomes of the evaluation and validation. Results Eighty-four study participants fully completed the HL-QoL. The result of the test-retest reliability analysis was high and highly significant ( n = 63; r = 0.914; p &amp;lt; 0.001). The mean total HL-QoL score (100.7 ± SD 24.58) suggests an overall high level of quality-of-life in this sample of people with hearing loss using a cochlear implant. The final version of the HL-QoL contains 21 items. Conclusion The HL-QoL has shown to be a valid and reliable tool to assess quality of life in people with hearing loss who use a cochlear implant. In addition to the total score, it is possible to calculate subscales based on the ICF components Body Functions and Activities and Participation .
Using the K-Nearest Neighbor Method and SMART Weighting in the Patent Document Categorization Subtask at NTCIR-6. (2007)

Patent processing is important in industry, business, and law. We participated in the classification subtask (at NTCIR-6 Patent Retrieval Task), in which, we classified patent documents into their F-terms using the k-nearest neighbor method. For document classification, F-term categories are both very precise and useful. We entered five systems in the classification subtask and obtained good results with them. Thus, we confirmed the effectiveness of our method. By comparing various similarity calculation methods, we confirmed that the SMART weighting scheme was the most effective method in our experiments.
Triterpenic Derivatives of Achillea alexandri‐regis Bornm. & Rudski. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
A natural bone cement - A laboratory novelty led to the development of revolutionary new biomaterials (2001)

Research on calcium phosphate chemistry at NIST led to the discovery of the worlds first self-hardening calcium phosphate cements (CPC) in 1987. Laboratory, animal, and clinical studies were conducted to develop CPC into clinically useful biomaterials. The combination of self-hardening capability and high biocompatibility makes CPC a unique material for repairing bone defects. Near perfect adaptation of the cement to the tissue surfaces in a defect, and a gradual resorption followed by new bone formation are some of the other distinctive advantages of this biomaterial. In 1996 a CPC, consisting of tetracalcium phosphate and dicalcium phosphate anhydrous, was approved by the Food and Drug Administration (FDA) for repairing cranial defects in humans, thus becoming the first material of its kind available for clinical use. This paper will review the course of the development, the physical and chemical properties, and clinical applications of CPC.
IL-33-Mediated Protection against Experimental Cerebral Malaria Is Linked to Induction of Type 2 Innate Lymphoid Cells, M2 Macrophages and Regulatory T Cells (2015)

Cerebral malaria (CM) is a complex parasitic disease caused by Plasmodium sp. Failure to establish an appropriate balance between pro- and anti-inflammatory immune responses is believed to contribute to the development of cerebral pathology. Using the blood-stage PbA (Plasmodium berghei ANKA) model of infection, we show here that administration of the pro-Th2 cytokine, IL-33, prevents the development of experimental cerebral malaria (ECM) in C57BL/6 mice and reduces the production of inflammatory mediators IFN-γ, IL-12 and TNF-α. IL-33 drives the expansion of type-2 innate lymphoid cells (ILC2) that produce Type-2 cytokines (IL-4, IL-5 and IL-13), leading to the polarization of the anti-inflammatory M2 macrophages, which in turn expand Foxp3 regulatory T cells (Tregs). PbA-infected mice adoptively transferred with ILC2 have elevated frequency of M2 and Tregs and are protected from ECM. Importantly, IL-33-treated mice deleted of Tregs (DEREG mice) are no longer able to resist ECM. Our data therefore provide evidence that IL-33 can prevent the development of ECM by orchestrating a protective immune response via ILC2, M2 macrophages and Tregs.
Towards tailoring non-invasive brain stimulation using real-time fMRI and Bayesian optimization (2016)

Non-invasive brain stimulation, such as transcranial alternating current stimulation (tACS) provides a powerful tool to directly modulate brain oscillations that mediate complex cognitive processes. While the body of evidence about the effect of tACS on behavioral and cognitive performance is constantly growing, those studies fail to address the importance of subjectspecific stimulation protocols. With this study here, we set the foundation to combine tACS with a recently presented framework that utilizes real-time fRMI and Bayesian optimization in order to identify the most optimal tACS protocol for a given individual. While Bayesian optimization is particularly relevant to such a scenario, its success depends on two fundamental choices: the choice of covariance kernel for the Gaussian process prior as well as the choice of acquisition function that guides the search. Using empirical (functional neuroimaging) as well as simulation data, we identified the squared exponential kernel and the upper confidence bound acquisition function to work best for our problem. These results will be used to inform our upcoming realtime experiments.
FPGA-based front-end electronics for positron emission tomography (2009)

Modern Field Programmable Gate Arrays (FPGAs) are capable of performing complex discrete signal processing algorithms with clock rates above 100MHz. This combined with FPGA's low expense, ease of use, and selected dedicated hardware make them an ideal technology for a data acquisition system for positron emission tomography (PET) scanners. Our laboratory is producing a high-resolution, small-animal PET scanner that utilizes FPGAs as the core of the front-end electronics. For this next generation scanner, functions that are typically performed in dedicated circuits, or offline, are being migrated to the FPGA. This will not only simplify the electronics, but the features of modern FPGAs can be utilizes to add significant signal processing power to produce higher resolution images. In this paper two such processes, sub-clock rate pulse timing and event localization, will be discussed in detail. We show that timing performed in the FPGA can achieve a resolution that is suitable for small-animal scanners, and will outperform the analog version given a low enough sampling period for the ADC. We will also show that the position of events in the scanner can be determined in real time using a statistical positioning based algorithm.
The Bioactive Phenolic Agents Diaryl Ether CVB2-61 and Diarylheptanoid CVB4-57 as Connexin Hemichannel Blockers (2022)

Inflammation mediators enhance the activity of connexin (Cx) hemichannels, especially in the epithelial and endothelial tissues. As potential release routes for injury signals, such as (oligo)nucleotides, Cx hemichannels may contribute to long-lasting inflammation. Specific inhibition of Cx hemichannels may therefore be a mode of prevention and treatment of long-lasting, chronic sterile inflammation. The activity of Cx hemichannels was analysed in N2A and HeLa cells transfected with human Cx26 and Cx46 as well as in Calu-3 cells, using dye uptake as functional assay. Moreover, the possible impacts of the bioactive phenolic agents CVB2-61 and CVB4-57 on the barrier function of epithelial cells was analysed using Calu-3 cells. Both agents inhibited the dye uptake in N2A cells expressing Cx26 (>5 µM) and Cx46 (>20 µM). In Calu-3 cells, CVB2-61 and CVB4-57 reversibly inhibited the dye uptake at concentrations as low as 5 µM, without affecting the gap junction communication and barrier function, even at concentrations of 20 µM. While CVB2-61 or CVB4-57 maintained a reduced dye uptake in Calu-3 cells, an enhancement of the dye uptake in response to the stimulation of adenosine signalling was still observed after removal of the agents. The report shows that CVB2-61 and CVB4-57 reversibly block Cx hemichannels. Deciphering the mechanisms of the interactions of these agents with Cx hemichannels could allow further development of phenolic compounds to target Cx hemichannels for better and safer treatment of pathologies that involve Cx hemichannels.
Toxin-producing fungi on feed grains and application of yeasts for their detoxification (2013)

Abstract The research deals with the contamination of feeding crops with fungi, producing mycotoxins and use of selected yeasts for detoxification. The thin-layer chromatography and ELISA methods were applied for the analysis of fungal secondary metabolites. The results showed a high rate of the grain contamination with fungi, mainly from genera Penicillium, Fusarium, Aspergillus and Alternaria. Some of the fungal strains produced 6-9 toxic compounds. The novelty of the study was the application of the yeast strains in detoxification of aflatoxins, zearalenon and deoxynivalenol in feed.
[Experimental and clinical studies on preoperative combined therapy using hyperthermia in carcinoma of the esophagus]. (1989)

In order to develop a new multidisciplinary treatment for carcinoma of the esophagus, we evaluate the effect of hyperthermia experimentally and clinically. Antitumor effect for squamous cell carcinoma arising spontaneously in a C3H/He Mouse is proved using hyperthermia only, and combined hyperthermia with irradiation and chemotherapy. Inhibited growth of tumor can lead to decrease of distant metastasis (Pulmonary metastasis). And hyperthermia itself does not induce increase of metastasis. There is a total of 32 patients of esophageal carcinoma receiving a preoperative combined treatment using hyperthermia. Nineteen patients received irradiation and hyperthermia. Thirteen received irradiation, immunochemotherapy and hyperthermia, Ef3 (complete disappearance of cancer cells) is obtained in 26.3% with the treatment using irradiation and hyperthermia, and 46.1% of Ef3 is found using irradiation, immunochemotherapy and hyperthermia. The above mentioned results are more favorable than the usual treatment using irradiation and immunochemotherapy without hyperthermia. Serrated, spiral, funnel type of esophagogram were used to be radiation resistant, however a satisfactory histological effect could be obtained by hyperthermia in addition to conventional irradiation. Because a high percentage of Ef3 is revealed even in A3 (invasion into the neighboring structures) cases, we can extend our indication of operation and our rate of curative resection is increased. Moreover, postoperative early local recurrence is decreased and it seems to improve the short term survival rate (3 years survival). We were afraid that combined treatment using hyperthermia might enhance remote lymph nodes metastases. But present study proves that it is not true. In conclusion, we recommend combined treatment using hyperthermia for A3 cases those are seemed to be difficult to resect because of invasion into the neighboring structures.
69.3: A Mechanics Framework for Ion‐Exchanged Cover Glass with a Deep Compression Layer (2009)

Abstract A cover glass that is capable of having a deep ion exchange compression layer enables one to tailor the glass to the intended device application. Key to this effort is having a glass mechanics framework that includes resistance to visible and strength‐limiting contact damage as well as maintaining sufficient strength to survive localized glass flexing during contact events.
Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform (2013)

Convincing epidemiological data suggest an inverse association between cancer and neurodegeneration, including Alzheimer's disease (AD). Since both AD and cancer are characterized by abnormal, but opposing cellular behavior, i.e., increased cell death in AD while excessive cell growth occurs in cancer, this motivates us to initiate the study into unraveling the shared genes and cell signaling pathways linking AD and glioblastoma multiform (GBM). In this study, a comprehensive bioinformatics analysis on clinical microarray datasets of 1,091 GBM and 524 AD cohorts was performed. Significant genes and pathways were identified from the bioinformatics analyses -in particular ERK/MAPK signaling, up-regulated in GBM and Angiopoietin Signaling pathway, reciprocally up-regulated in AD -connecting GBM and AD (P , 0.001), were investigated in details for their roles in GBM growth in an AD environment. Our results showed that suppression of GBM growth in an AD background was mediated by the ERK-AKT-p21-cell cycle pathway and anti-angiogenesis pathway.
Folic Acid and Prevention of Birth Defects-Reply (1996)

<h3>In Reply.</h3> —The letter by Dr Czeizel about the protective effect of a multivitamin preparation containing folic acid on NTDs and other congenital malformations raises an important public health issue. It is now accepted that periconceptional folic acid prevents both the recurrence and occurrence of NTDs. However, we wish to emphasize that the evidence to date regarding the effects of folic acid in preventing other birth defects, cardiovascular disease, or some cancers is much more tenuous. Most of the studies examining these questions were observational rather than randomized, and the protective effects, in the main, were related to multivitamins that happened to include folic acid. In particular, the protective effects on birth defects noted in the letter by Czeizel, though based on a randomized trial, were for a preparation that contained folic acid as just 1 of many ingredients. The efficacy of folic acid per se in conditions other than
The Mechanical Destruction of Bacteria (1948)

Summary: A number of different organisms were subjected to violent shaking with minute round glass particles. Vegetative bacteria, spores, and acid-fast species were killed by this treatment, though at varying rates.
COST EFFECTIVE PERFORMANCE DRIVEN IMPROVED SAFETY BENEFITS FROM HORIZONTAL PAINTED PAVEMENT MARKING SYSTEMS (2003)

Horizontal painted pavement marking materials are applied to road surfaces to provide safe guidance for the traveling road user public. These markings need to function both day and night, wet and dry, to provide safe guidance and clear signals at a consistent level while presenting a preview of the forward road geometry. Such delineation systems may create a potential hazard if the differential friction between the marking and the pavement exists, particularly for cyclists and motorcyclists. Potters Industries, has taken the initiative in developing safer systems and generating data to assist the pavement marking industry. Requirements for Performance Based Contracts for pavement markings are fast approaching, with little data to assist the specifying engineer on realistic intervention levels that can deliver safe performance outcomes. These 'safe outcomes' should include minimum levels in dry night visibility, wet night visibility and skid resistance for both transverse and longitudinal pavement markings, throughout the life of these markings. To provide the anticipated levels of skid resistance, usually requires a surface application of angular particles. These angular particles may create shadows over the surface applied glass beads and render the line invisible during night conditions. The challenge has been to find a balance between angular and spherical surface applied particles, in size, quality, quantity, ratio and method of application, that can provide durable cost effective horizontal pavement markings with excellent dry night delineation, excellent wet night delineation and a high level of skid resistance.
Prosodic signatures of ASD severity and developmental delay in preschoolers (2023)

Atypical prosody in speech production is a core feature of Autism Spectrum Disorder (ASD) that can impact everyday life communication. Because the ability to modulate prosody develops around the age of speech acquisition, it might be affected by ASD symptoms and developmental delays that emerge at the same period. Here, we investigated the existence of a prosodic signature of developmental level and ASD symptom severity in a sample of 74 autistic preschoolers. We first developed an original diarization pipeline to extract preschoolers' vocalizations from recordings of naturalistic social interactions. Using this novel approach, we then found a robust voice quality signature of ASD developmental difficulties in preschoolers. Furthermore, some prosodic measures were associated with one year later outcome in participants who had not acquired speech yet. Altogether, our results highlight the potential benefits of automatized diarization algorithms and prosodic metrics for digital phenotyping in psychiatry, helping clinicians establish early diagnosis and prognosis.
Studies on pepsin inhibitor (S-PI) from Streptomyces naniwaensis. IV. Effect of a microbial acid protease inhibitor (S-PI) on the production of fungal acid protease. (1975)

Cladosporium sp. No. 45-2, an acid protease-producing microorganism, was cultured in medium containing a microbial acid protease inhibitor (S-PI). By the addition of S-PI, the amount of acid protease in the culture broth showed an increase of 50_??_80%. over those of normal culture (S-PI-free). Acid protease was purified from the S-PI-added culture filtrate, and its enzymatic and physicochemical properties were compared with those of acid protease obtained from normal culture. It was determined that the acid protease obtained from S-PT-added culture was the same as that of normal culture, but that the productivity was increased by the addition of S-PI. The increase in acid protease productivity is assumed to be due to a change in metabolism by the addition of S-PI.
[Surgical management of pancreatic metastasis from renal cell carcinoma]. (2001)

Le metastases de localisation pancreatique sont rares et representent 2 % des indications d'exerese pancreatique dans les series chirurgicales. La place de la chirurgie d'exerese pour les metastases delocalisation pancreatique n'est pas encore definie. Nous rapportons les cas de 9 malades ayant des metastases de localisation pancreatique de cancer du rein, traites par duodeno-pancreatectomie cephalique ou pancreatectomie totale. La symptomatologie, le traitement chirurgical et la survie sont analyses.
Anterior Lumbar Interbody Fusion (1988)

This is a report of 85 patients who underwent anterior lumbar interbody fusion (ALIF) for treatment of painful disc disruption (PDD) or symptomatic pseudarthrosis. The fusion rate was 80% by disc. The pseudarthrosis rate increased from 16% at L5-S1 to 21% and 31% at L4-5 and L3-4, respectively. There was a significant increase in pseudarthrosis rate in patients who smoked more than one pack per day. There was no difference in the fusion rate whether autogenous or cadaveric iliac crest graft or dowel versus tricortical block graft was used. Sixty-eight percent of patients were "able to work" after ALIF. The complication rate was low and retrograde ejaculation occurred in only one patient.