gebhart/patrepeval huggingface dataset:
Identification of Squamous Intraepithelial Lesions: Fluorescence of Cervical Tissue During Colposcopy (1999)

Abstract Objective. Our objective in this study was to improve the accuracy of colposcopically directed biopsy. Method. Women attending a colposcopy clinic because of an abnormal cytological cervical smear were entered into the study. A total of 154 cervical biopsy sites were investigated, using a fluorescence device developed to examine the differences in the spectral signatures of cervical tissue in different disease states. Acetowhite changes underwent biopsy, and a spectral signal was obtained. Each biopsy-optical pair was analyzed as an independent site, and the results were presented as independent comparisons of the paired data. Two groups of data are presented. Results. The optical readings indicated the presence or absence of any grade of cervical intraepithelial neoplasia with a specificity of 94.2% and 93.3%, respectively, and a sensitivity of 93.1% and 89.3%, respectively. The negative predictive values were 96.1% and 93.3%, respectively; the positive predictive values were 90% and 89.3%, respectively. Conclusion. The accuracy of the optical readings in this series was 93 to 94%. This methodology, with its excellent sensitivity, may serve a role in ensuring that all cervical intraepithelial neoplasia grades 2 and 3 lesions are identified and are subjected to biopsy during colposcopy.
Ipsilateral Periprosthetic Fractures above and below the Knee Associated with Navigation Tracker Pin and Bone Fragility. (2023)

We report a case of ipsilateral periprosthetic fractures above and below the knee that occurred at different times due to navigation tracker pin and bone fragility. A 66-year-old Japanese woman with rheumatoid arthritis (RA) underwent a total knee arthroplasty. Four months post-surgery, a periprosthetic fracture above the knee at the navigation pin hole was detected. She underwent osteosynthesis and could walk independently, but she developed an ipsilateral tibial component fracture. Conservative treatment with a splint was followed by bone union. Patients with RA treated with oral steroids tend to develop ipsilateral periprosthetic fractures around the knee due to bone fragility.
Acetaldehyde-mediated cilia dysfunction in bovine bronchial epithelial cells (1991)

Acetaldehyde, which is present in significant concentrations in cigarette smoke and is elevated during alcohol ingestion, has been demonstrated to impair mucociliary clearance of the lung. Acetaldehyde is also known to impair protein function through the formation of acetaldehyde-protein adducts. We hypothesized that acetaldehyde impairs bronchial epithelial cilia motion by inhibiting cilia dynein adenosinetriphosphatase (ATPase) activity through the formation of acetaldehyde adducts with cilia proteins. Acetaldehyde induced concentration- and time-dependent slowing of cilia beating and cilia-derived dynein ATPase activity in primary cultures and isolated axonemes of bovine airway epithelial cells. Cilia slowing and ATPase inhibitory effects were also observed with related aldehydes but not with ethanol. Acetaldehyde binding, assessed by gel electrophoresis using [14C] acetaldehyde, was demonstrated to occur with the dynein heavy chains and with tubulin and closely paralleled ATPase inhibition. We conclude that acetaldehyde directly impairs bronchial cilia function causing slowing of cilia beating, inhibits cilia dynein ATPase activity, and binds to cilia proteins critical for motion including dynein and tubulin. These data suggest that acetaldehyde-induced cilia dysfunction may be related to direct cilia ATPase inactivation and adduct formation with cilia dynein and tubulin. This may be an important mechanism by which airway host defenses are impaired in clinical settings where acetaldehyde exposure occurs, e.g., with cigarette smoking and alcohol ingestion.
Ubiquitous animated agents for augmented reality (2006)

Most of today's Augmented Reality (AR) systems operate as passive information browsers relying on a finite and deterministic world model and a predefined hardware and software infrastructure. We propose an AR framework that dynamically and proactively exploits hitherto unknown applications and hardware devices, and adapts the appearance of the user interface to persistently stored and accumulated user preferences. Our framework explores proactive computing, multi-user interface adaptation, and user interface migration. We employ mobile and autonomous agents embodied by real and virtual objects as an interface and interaction metaphor, where agent bodies are able to opportunistically migrate between multiple AR applications and computing platforms to best match the needs of the current application context. We present two pilot applications to illustrate design concepts.
Use of interferon in the treatment of chronic myelogenous leukemia. (1994)

In a series of studies spanning 14 years, investigators from M.D. Anderson Cancer Center (Houston, TX) documented the activity of interferon-alfa (IFN-alpha) in chronic myelogenous leukemia (CML). Beginning with partially purified IFN-alpha, we demonstrated that this biologic compound has clinical activity against CML, that some malignancies are resistant to IFN-alpha, and that the effect is selective whereby the malignant clone can be restored to normalcy. These observations were confirmed by us and others when larger quantities of IFN-alpha became available through recombinant DNA technology (rIFN-alpha). In contrast with our experience with chemotherapy, myelosuppression was not required for cytogenetic remission; this dissociation may be the basis for the selectivity of IFN-alpha against CML. Recently, another group demonstrated that patients randomized to receive rIFN-alpha 2a survived longer than those treated with standard hydroxyurea chemotherapy. New tests are needed to identify the subset of patients most likely to benefit from IFN-alpha therapy and to distinguish cytogenetic responders who are truly cured from those with minimal residual disease.
Marked enhancement in gene expression by targeting the human insulin receptor (2002)

The extent to which an exogenous gene is expressed within a cell via a nonviral, receptor-mediated gene transfer technology is determined by the receptor specificity of the targeting ligand. The highest levels of gene expression are obtained after targeting the insulin receptor, and this may derive from the nuclear targeting properties of this receptor system.
Localisation and differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal and atherosclerotic human arteries (1996)

These data provide evidence to suggest involvement of the FGF-FGFR multigene families in human atherogenesis. Differential FGFR expression in plaque subtypes may reflect distinct differences in receptor function which may be relevant to lesion progression during atherosclerosis.
On-the-Fly Substrate Eccentricity Recognition for Robotized Manufacturing Systems (2005)

This paper describes a method for on-the-fly determination of eccentricity of a circular substrate, such as a silicon wafer in semiconductor manufacturing applications, carried by a robotic manipulator, where eccentricity refers to the difference between the actual location of the center of the substrate and its desired position on the end-effector of the robotic manipulator. The method utilizes a pair of external optical sensors located along the substrate transfer path. When moving a substrate along the transfer path, the robotic manipulator captures the positions and velocities of the end-effector at which the edges of the substrate are detected by the sensors. These data along with the expected radius of the substrate and the coordinates of the sensors are used to determine the eccentricity of the substrate. This information can be used by the robotic manipulator to compensate for eccentricity of the substrate when performing a place operation, resulting in the substrate being placed centered regardless of the amount and direction of the initial eccentricity. The method can also be employed to detect a defect, such as breakage, of a circular substrate and report an error condition which can abort or otherwise adjust operation of the robotic manipulator.
Cost effective, robust, and reliable coupled separation techniques for the identification and quantification of phospholipids in complex biological matrices: Application to insects (2014)

The quantification of phospholipid classes and the determination of their molecular structures are crucial in physiological and medical studies. This paper's target analytes are cell membrane phospholipids, which play an important role in the seasonal acclimation processes of poikilothermic organisms. We introduce a set of simple and cost-effective analytical methods that enable efficient characterization and quantification of particular phospholipid classes and the identification and relative distribution of the individual phospholipid species. The analytical approach involves solid-phase extraction and high-performance thin-layer chromatography, which facilitate the separation of particular lipid classes. The obtained fractions are further transesterified to fatty acid methyl esters and subjected to gas chromatography coupled to flame ionization detection, which enables the determination of the position of double bonds. Phospholipid species separation is achieved by high-performance liquid chromatography with mass spectrometry, which gives information about the headgroup moiety and attached fatty acids. The total content of each phospholipids class is assessed by phosphorus determination by UV spectrophotometry. The simultaneous analysis of phosphorus, fatty acid residues, and phospholipid species provides detailed information about phospholipid composition. Evaluation of these coupled methods was achieved by application to an insect model, Pyrrhocoris apterus. High correlation was observed between fatty acid compositions as determined by gas chromatography and high-performance liquid chromatography analysis.
Measuring Surface Roughness on Base of the Circular Polarization Coherence as an Input for a Simple Inversion of the IEM Model (2003)

In this paper a simple inversion approach is applied at the integral equation method model for single scattering (IEM). The inversion of the radar backscatter into soil moisture was accomplished with an iterative method. To date most inversion approaches with use of the IEM try to determine both the surface roughness and the soil moisture on base of two copolarized radar channels. Because there are a number of possible combinations of roughness and moisture parameters to reach the same values for the radar backscatter, these approaches always contain a fragment of uncertainty and inaccurateness. Therefore this work follows the idea of arising the number of input variables to reduce the inaccurateness and ambiguity of the inversion results. For this reason the surface roughness parameters are declared as input variables and were calculated externally of the IEM. The base for computing the rms-height values (s) is the circular polarization coherence of the copolarized channels. The real part of this coherence was found to be a good measure for this surface roughness parameter. For agricultural surfaces the correlation length of the autocorrelation function was found to correlate with the rms-heights. Because of the fact, that the autocorrelation length is not the most deciding parameter, this contiguity was used to calculate the autocorrelation length from the s. The final result in the form of a soil moisture map seems quite promising. Good correlations between measured and modelled values were realised. The arrangement of the soil moisture outside the test areas is rather realistic, which means higher values in depressed areas and lower values on hilltops. 1
ChemInform Abstract: Cyclohexenone Anellation by Alkylidene C‐H Insertion: Synthesis of Oxo‐ T‐cadinol. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Automated acquisition of knowledge beyond pathologists (2019)

Abstract Deep learning algorithms have been successfully used in medical image classification and cancer detection. In the next stage, the technology of acquiring explainable knowledge from medical images is highly desired. Herein, fully automated acquisition of explainable features from annotation-free histopathological images is achieved via revealing statistical distortions in datasets by introducing the way of pathologists’ examination into a set of deep neural networks. As validation, we compared the prediction accuracy of prostate cancer recurrence using our algorithm-generated features with that of diagnosis by an expert pathologist using established criteria on 13,188 whole-mount pathology images. Our method found not only the findings established by humans but also features that have not been recognized so far, and showed higher accuracy than human in prognostic prediction. This study provides a new field to the deep learning approach as a novel tool for discovering uncharted knowledge, leading to effective treatments and drug discovery.
Adult respiratory distress syndrome (1985)

We describe the use of continuous negative extra-thoracic pressure to treat successfully the adult respiratory distress syndrome in a 19-yr-old woman who resisted the application of positive airway pressure. Arterial hypoxemia was reversed with −26 cm H2O of extrathoracic pressure, produced by a modified Emerson iron lung. Cerebral and renal functions were maintained, and barotrauma did not occur. The patient required aontinuous negative extrathoracic pressure for 9 days; 12 days after admission, she was discharged. This case indicates that negative extrathoracic pressure therapy can be an effective and safe alternative to positive airway pressure for the management of selected patients with adult respiratory distress syndrome.,
1‐alkynyldioxaborolanes: Determination of 1J(13C,11B) from 13C NMR studies at 102°C (1995)

Abstract Broad 13 C resonances, as the result of partially relaxed scalar 13 C 11 B coupling, were observed for the C‐1 and to a lesser extent C‐2 carbons of 1‐alkynyldioxaborolanes at 25°C. Measurement of the 13 C spectra at 102°C resulted in a slower 11 B quadrupolar relaxation rate and allowed the determination of 1 J ( 13 C, 11 B) scalar coupling from the resulting quadruplets for the C‐1 carbon.
The neural basis of language development: Changes in lateralization over age (2020)

We have long known that language is lateralized to the left hemisphere (LH) in most neurologically healthy adults. In contrast, findings on lateralization of function during development are more complex. As in adults, anatomical, electrophysiological, and neuroimaging studies in infants and children indicate LH lateralization for language. However, in very young children, lesions to either hemisphere are equally likely to result in language deficits, suggesting that language is distributed symmetrically early in life. We address this apparent contradiction by examining patterns of functional MRI (fMRI) language activation in children (ages 4 through 13) and adults (ages 18 through 29). In contrast to previous studies, we focus not on lateralization per se but rather on patterns of left-hemisphere (LH) and right-hemisphere (RH) activation across individual participants over age. Our analyses show significant activation not only in the LH language network but also in their RH homologs in all of the youngest children (ages 4 through 6). The proportion of participants showing significant RH activation decreases over age, with over 60% of adults lacking any significant RH activation. A whole-brain correlation analysis revealed an age-related decrease in language activation only in the RH homolog of Broca's area. This correlation was independent of task difficulty. We conclude that, while language is left-lateralized throughout life, the RH contribution to language processing is also strong early in life and decreases through childhood. Importantly, this early RH language activation may represent a developmental mechanism for recovery following early LH injury.
Resistive switching properties of amorphous Pr0.7Ca0.3MnO3 films grown on indium tin oxide/glass substrate using pulsed laser deposition method (2012)

Amorphous Pr0.7Ca0.3MnO3 (APCMO) films, which were grown on indium tin oxide (ITO)/glass at room temperature (RT), were n-type materials. The APCMO/ITO/glass device exhibited an average transparency of 77% in the visible range with a maximum transparency of 84% at a wavelength of 530 nm. The Pt/APCMO/ITO device showed stable bipolar resistive switching behavior over 200 cycles that did not degrade after 105 s at RT. The resistance of the APCMO film decreased in both low- and high-resistance states with increasing device area. The resistive switching behavior of the Pt/APCMO/ITO device can be explained by the trap-charged space-charge-limited current mechanism.
Near infra-red emission from a mer-Ru(ii) complex: consequences of strong σ-donation from a neutral, flexible ligand with dual binding modes (2014)

A rare example of dual coordination modes by a novel tridentate ligand gives rise to unique fac-and mer-Ru((II/III)) complexes. The mer-Ru(II)-complex displays the farthest red-shift of a triplet metal-to-ligand charge transfer ((3)MLCT) emission with a tridentate ligand for a mononuclear complex. This observation is a consequence of large bite angle and strong σ-donation by the ligand, the combined effect of which helps to separate the energy of the (3)MLCT and (3)MC states.
Reference Values of Serum IgA Subclasses in Caucasian Adults by Immunonephelometry (1999)

identified in this gene, SNPs (12, 13) remain the only available genetic markers for linkage analysis to identify presymptomatic carriers in AIP families.
Genome-wide association study of pigmentary traits (skin and iris color) in individuals of East Asian ancestry (2017)

Additional genome-wide association studies in East Asian samples will be necessary to further disentangle the genetic architecture of pigmentary traits in East Asian populations.
Laser conditioning methods of hafnia-silica multilayer mirrors (1999)

A variety of 1064-nm laser conditioning methods were investigated to find the optimum method for production of large aperture (0.25 m2) multilayer coatings for the National Ignition Facility and Laser MegaJoule. Two conditioning methods were explored, multi-step and single-step on two different laser systems. Off-line conditioning was done on PLATO, a small beam diameter ('-1 mm) raster scanning system. On-line conditioning was done on Beamlet, a single beam prototype of the National Ignition Facility with a large rectangular beam (35 cm x 35 cm). Concurrent with this work, coating process development for low-defect density high damage threshold coatings was realized by switching from hafnia to hafnium starting materials. The results of this study suggest that single-step raster-scan off-line laser conditioning is an effective method to raise the damage threshold of multilayer mirrors deposited from hafnium and silica by reactive electron beam deposition.
Improvement of robustness against write disturbance by novel cell design for high density MRAM (2004)

A new bit cell designed to have an excellent astroid is presented from the viewpoints of both theory and experiment. The switching mechanism is unique. The robustness against the disturbance of half-selected bits is improved. Its excellent astroid improves thermal stability and has the potential to achieve extremely high density magnetoresistive random access memory (MRAM).
Effect of S267F variant of NTCP on the patients with chronic hepatitis B (2017)

Sodium taurocholate cotransporting polypeptide (NTCP) was identified as an entry receptor for hepatitis B virus (HBV) infection. The substitution of serine at position 267 of NTCP with phenylalanine (S267F) is an Asian-specific variation that hampers HBV entry in vitro. In this study, we aimed to evaluate the prevalence of S267F polymorphism in Korean patients with chronic hepatitis B (CHB) and its association with disease progression and potential viral evolution in the preS1 domain of HBV. We found that the frequency of the S267F variant of NTCP in CHB patients and controls was 2.7% and 5.7% (P = 0.031), respectively, and that those who had S267F variant were less susceptible to chronic HBV infection. The frequency of the S267F variant in CHB, cirrhosis and hepatocellular carcinoma (HCC) patients was 3.3%, 0.9%, and 3.5%, respectively. Thus, the S267F variant correlated significantly with a lower risk for cirrhosis (P = 0.036). Sequencing preS1 domain of HBV from the patients who had S267F variant revealed no significant sequence change compared to the wild type. In conclusion, the S267F variant of NTCP is clinically associated with a lower risk of chronic HBV infection and cirrhosis development, which implicates suppressing HBV entry could reduce the disease burden.
Auditory Stroop Using Spatial Stimuli (2017)

Purpose: The purpose of this study is to evaluate the influence of spatial auditory stimuli when the semantic meaning of the spoken word is incongruent with the location of the sound. Based on previous auditory Stroop research we predict that individuals will respond to incongruent stimuli with reduced accuracy and prolonged reaction times. Methods: Twenty students between the ages of 18–30 were presented with a word indicating a direction that included location cues representing the same or different direction. Stimuli were presented in the horizontal plane (i.e., left, center, right) and in the vertical plane (i.e., up, center, down). Participants were instructed to answer verbally the direction of the sound source rather than the direction the spoken word indicated. Accuracy and reaction times were analyzed in both planes. Results: Generally, for stimuli in the horizontal plane, accuracy was high and reaction times were low, regardless of congruency. However, there was a significantly higher frequency of errors in vertical-congruent conditions than in horizontal conditions. The frequency of vertical-incongruent errors was higher still. The pattern of reaction time results matched the accuracy results. Conclusions: Despite the simulated source angle being well above the minimal audible angle in both planes, the results suggest a lower salience in the vertical domain. If seeking to develop a multi-dimensional auditory map for sound selection, the horizontal plane is most likely to result in the clearest representations of sound-source location.
Evaluation of an Automatic Speaker-Verification System Over Telephone Lines (1976)

An automatic speaker-verification system accessed by test customers from their own telephones over dialed-up lines has been evaluated. The test population consisted of over 100 male and female speakers who called up nominally once each working day over a period of five months. The operation of the system is based on a set of functions of time obtained from acoustic analysis of a fixed, sentence-long utterance. These functions are compared with stored reference functions to determine whether to accept or reject an identity claim. The system is implemented on a NOVA 800 laboratory computer. Telephone line access to the computer is via a data set hookup. Identity claims are made by keying an identification number on a Touch-Tone® dial. Instructions and responses to the customer are made by means of a programmed voice-response system. Reference data was computed off-line and updated with the analysis data of accepted utterances. The evaluation indicated an error rate of approximately 10 percent for new customers and approximately 5 percent for adapted customers.