gebhart/patrepeval huggingface dataset:
Lightweight Replication Through Remote Backup Memory Sharing for In-memory Key-Value Stores (2017)

Memory price will continue dropping in the next few years according to Gartner. Such trend renders it affordable for in-memory key-value stores (IMKVs) to maintain redundant memory-resident copies of each key-value pair to provision enhanced reliability and high availability services. Though contemporary IMKVs have reached unprecedented performance, delivering single-digit microsecond-scale latency with up to tens of millions queries per second throughput, existing replication protocols are unable to keep pace with such an advancement of IMKVs, either incurring unbearable latency overhead or demanding intensive resource usage. Consequently, the adoption of those replication techniques always results in substantial performance degradation.In this paper, we propose MacR, a RDMA-based high-performance and lightweight replication protocol for IMKVs. The design of MacR centers around sharing the remote backup memory to enable RDMA-based replication protocol, and synthesizes a collection of optimizations, including memory allocator cooperative replication and adaptive bulk data synchronization to control the number of network operations and to enhance the recovery performance. Performance evaluations with a variety of YCSB workloads demonstrate that MacR can efficiently outperform alternative replication methods in terms of the throughput while preserving sufficiently low latency overhead. It can also efficiently speed up the recovery process.
Supplementary Tables S1-S7 from <i>KEAP1/NFE2L2</i> Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition (2023)

&lt;p&gt;Table S1 - S7&lt;/p&gt;
Charge Transport at High Pressures in toluene-n-pentane Mixtures (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharge Transport at High Pressures in toluene-n-pentane MixturesKengo Itoh, Shiro Ninomiya, Masaru Nishikawa, and Richard A. HolroydCite this: J. Phys. Chem. 1994, 98, 7, 1974–1977Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/j100058a042https://doi.org/10.1021/j100058a042research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Driving T cells to human atherosclerotic plaques: CCL3/CCR5 and CX3CL1/CX3CR1 migration axes (2021)

T-cell accumulation in atherosclerotic plaques contributes to plaque destabilization. We found that several chemokine receptors are differentially expressed on peripheral blood compared to plaque-resident T cells and corresponding ligands are upregulated in plaques. These data indicate that T-cell migration into human atherosclerotic plaques may predominantly occur via CCR5-CCL3 and CX3CR1-CX3CL1 interactions.
P04.02 Postponing the medical treatment is possible in selected cases of diffuse low-grade glioma with foci of WHO grade III-IV after total or subtotal resection (2019)

Abstract BACKGROUND Diffuse low-grade gliomas (DLGG) are defined by a continuous growth and an unavoidable malignant transformation. Foci of malignant transformation may be found within DLGG samples obtained from surgical resections. As the medical management is classically based on the higher tumor grade, an immediate adjuvant treatment is usually proposed (radiotherapy [RT] with Temozolomide or PCV), whatever the extent of resection. Yet, early RT has no impact on overall survival compared with late RT, and is associated with cognitive toxicity. An alternative approach consists in postponing the medical treatment in selected patients. MATERIAL AND METHODS We conducted a monocentric retrospective analysis of a consecutive series of patients managed with this conservative approach. Inclusion criteria were: DLGG (WHO 2016 grade II) with at least one focus of malignant transformation (grade III-IV); no previous chemotherapy or RT; no less than a subtotal resection of the FLAIR tumor volume; no intention of treating with immediate adjuvant therapy; at least two years of postoperative follow-up. The time interval to the next medical treatment (chemotherapy and/or radiotherapy) was assessed, as well as the functional and survival results. RESULTS Forty-five DLGG patients, of median age 36.5 years, were included in the analysis (median time interval from diagnosis: 7.3 months). The histo-molecular diagnosis was diffuse astrocytoma, IDH mutant in 46.7% of cases, astrocytoma, IDH wild-type in 13.3% and oligodendroglioma, IDH mutant and 1p/19q codeleted in 40.0%. Ten tumors presented with grade IV foci. The quality of resection was subtotal (FLAIR tumor residue ≤15 cm3) in 73.3%, total (no FLAIR tumor residue) in 24.4% and supratotal in 2.2%. After surgery, patients were managed with regular clinical and radiological follow-up. With a median postoperative follow-up of 6.3 years, 75.5% of patients received a subsequent medical treatment, after a median time interval of 3.7 years. The first treatment after surgery consisted of repeated surgery in 11 patients, Temozolomide in 28 patients, RT in one patient. At the time of analysis, 19 patients (42.2%) had been treated with RT, after a median time interval of 9.5 years. Nine patients (20.0%) had died (median overall survival not reached, 5-years and 7-years survival rates: 95.2% and 67.0%). Most surviving patients were still active professionally (69.4%), with a median Karnofsky performance status of 90, and no or rare seizures. CONCLUSION In this series, total or subtotal resection of DLGG with a least one focus of grade III-IV glioma radically changed the natural history of these tumors and allowed delaying the following medical treatment by several years. This strategy is feasible in selected patients and should be considered on a case-by-case basis in patients with foci of malignant transformation following total or subtotal resection.
Erratum to: Role of the site of protonation in the low-energy decompositions of gas phase peptide ions (1996)

ADVERTISEMENT RETURN TO ISSUEPREVAdditions & Corr...Additions & CorrectionsNEXTORIGINAL ARTICLEThis notice is a correctionErratum to: Role of the site of protonation in the low-energy decompositions of gas phase peptide ionsK. A. CoxK. A. CoxMore by K. A. Cox, S. J. GaskellS. J. GaskellMore by S. J. Gaskell, M. MorrisM. MorrisMore by M. Morris, and A. WhitingA. WhitingMore by A. WhitingCite this: J Am Soc Mass Spectrom 1996, 7, 8, 759Publication Date (Web):August 1, 1996Publication History Published online1 August 1996Published inissue 1 August 1996https://pubs.acs.org/doi/10.1016/1044-0305(96)00066-9https://doi.org/10.1016/1044-0305(96)00066-9correctionACS PublicationsCopyright © 1996 © American Society for Mass Spectrometry 1996. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views13Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (178 KB) Get e-Alerts
Phylogeography of coral reef fishes (2015)

The field of phylogeography seeks to shed light on the ecology and evolution of organisms by resolving genetic relationships across a geographic range. This includes comparisons among isolated populations, subspecies partitions, sister species, and more ancient separations. The staple method employed in phylogeographic studies has been mitochondrial DNA sequencing; however, the field has kept abreast of technical developments, with nuclear DNA sequencing and microsatellite fragment analysis now commonly used to resolve genetic patterns, and single nucleotide polymorphisms (SNPs) and next-generation sequencing technologies becoming increasingly popular. This review is focused on the contributions phylogeography has made to understanding reef fish dispersal, evolutionary divergence, and conservation. Examples of these findings include the following: (1) genetic surveys of reef fishes often reveal multiple evolutionary lineages within a species' range; (2) genetic connectivity by larval transport can vary from a few kilometers in anemone fishes, to entire ocean basins in unicorn fishes and other species with long larval stages; (3) biogeographic provinces, defined by species distributions, are often concordant with genetic partitions for widespread species; (4) new species arise in biodiversity hotspots like the Coral Triangle and Caribbean Sea, but these areas can also accumulate species that originate in peripheral oceanic islands; (5) both biodiversity hotspots and peripheral areas of high endemism should be conservation priorities; and (6) parentage analyses with “DNA fingerprints” show that some larvae settle close to their origin, reinforcing the conservation value of marine protected areas (MPAs). We conclude with a discussion of how rapidly developing methods for genomic sequencing are revolutionizing the field, allowing for the first time an in-depth exploration of the ecological and environmental factors that influence genomes, and the genetic building blocks for future biodiversity.
Effect of Film-Hole Shape on Turbine-Blade Heat-Transfer Coefficient Distribution (2001)

Detailed heat-transfer coefe cient distributions on the suction side of a gas turbine blade were measured using a transient liquid crystal image method. The blade has only one row of e lm holes near the gill-hole portion on the suction side of the blade. Studies on three different kinds of e lm-cooling hole shapes were presented. The hole geometriesstudied includestandard cylindricalholesand holeswith adiffuser-shaped exitportion (i.e., fan-shaped holes and laidback fan-shaped holes ). Tests were performed on a e ve-blade linear cascade in a low-speed wind tunnel. The mainstream Reynolds number based on the cascade exit velocity was 5 :3 ££ 10 5 . Upstream unsteady wakes were simulated using a spoke-wheel-type wake generator. The wake Strouhal number was kept at 0 and 0.1. The coolant-to-mainstream blowing ratio was varied from 0.4 to 1.2. The results show that unsteady wake generally tends to induce earlier boundary-layer transition and enhance the surface heat-transfer coefe cients. When compared to the cylindrical hole case, both the expanded hole injections have much lower heat-transfer coefe cients over the surface downstream of the injection location, particularly at high blowing ratios. However, the expanded hole injections induce earlier boundary-layer transition to turbulence and enhance heat-transfer coefe cients at the latter part of the blade suction surface.
Maternal postural challenge as a functional test for cervical incompetence (1997)

We studied the effect of an upright maternal position on the cervix. Of 41 high risk patients (17 to 33 weeks' gestational age), 14 of 16 who had a greater than 33% decrease in cervical length in the upright position compared to supine position delivered their infants prematurely, compared to 1 of 25 patients who had a decrease of less than 33% (P < 0.0005). No change in the cervical length was noted in 24 low-risk patients, all of whom were delivered at term. When the finding of a cervical length of less than 2 cm was combined with a postural change, the sensitivity for prediction of preterm delivery was 100%. We conclude that for patients at high risk for incompetent cervix, maternal posture-related cervical shortening can assist in predicting those who will undergo premature delivery.
Thymoquinone-Loaded Polymeric Films and Hydrogels for Bacterial Disinfection and Wound Healing (2020)

The purpose of this study was to synthesize and characterize novel biocompatible topical polymeric film and hydrogel systems that have the potential to deliver the antibacterial agent thymoquinone (TQ) directly to the skin target site to manage the local wound infection and thereby wound healing. The polyvinyl pyrrolidone (PVP) matrix-type films containing TQ were prepared by the solvent casting method. In vitro skin permeation studies on human cadaver skin produced a mean flux of 2.3 µg TQ/cm<sup>2</sup>/h. Human keratinocyte monolayers subjected to a scratch wound (an in vitro wound healing assay) showed 85% wound closure at day 6 in the TQ group (100 ng/mL TQ) as compared to 50% in the vehicle control group (<i>p</i> = 0.0001). In a zone-of-inhibition (ZOI) assay, TQ-containing films and hydrogels completely wiped out <i>Staphylococcus aureus</i> in 10 cm diameter Tryptic Soy Agar plates while 500 µg/mL gentamicin containing filters gave 10 mm of ZOI. In an ex vivo model, TQ-containing films eradicated bacterial colonization on human cadaver skin. Furthermore, in a full-thickness wound infection model in mice, TQ-containing films showed significant activity in controlling <i>Staphylococcus aureus</i> infection, thereby disinfecting the skin wound. In summary, TQ-containing PVP films and hydrogels developed in this study have the potential to treat and manage wound infections.
ChemInform Abstract: EMK‐MESSUNGEN BEI HOHER TEMPERATUR AN SULFID BILDENDEN ZELLEN (1972)

Abstract Die EMK‐Messungen an den Sulfid bildenden Zellen A werden bei 600°C unter Verwendung einer S‐Dampfelektrode durchgeführt.
Virtual landmarks (2017)

Much has been published on finding landmarks <i>on</i> object surfaces in the context of shape modeling. While this is still an open problem, many of the challenges of past approaches can be overcome by removing the restriction that landmarks <i>must be</i> on the object surface. The <i>virtual landmarks</i> we propose may reside inside, on the boundary of, or outside the object and are tethered to the object. Our solution is straightforward, simple, and recursive in nature, proceeding from global features initially to local features in later levels to detect landmarks. Principal component analysis (PCA) is used as an engine to recursively subdivide the object region. The object itself may be represented in binary or fuzzy form or with gray values. The method is illustrated in 3D space (although it generalizes readily to spaces of any dimensionality) on four objects (liver, trachea and bronchi, and outer boundaries of left and right lungs along pleura) derived from 5 patient computed tomography (CT) image data sets of the thorax and abdomen. The virtual landmark identification approach seems to work well on different structures in different subjects and seems to detect landmarks that are homologously located in different samples of the same object. The approach guarantees that virtual landmarks are invariant to translation, scaling, and rotation of the object/image. Landmarking techniques are fundamental for many computer vision and image processing applications, and we are currently exploring the use virtual landmarks in automatic anatomy recognition and object analytics.
Sharp separation of C2/C3 hydrocarbon mixtures by zeolitic imidazolate framework-8 (ZIF-8) membranes synthesized in aqueous solutions (2011)

Exceptional high quality ZIF-8 membranes prepared through a novel seeded growth method in aqueous solutions at near room temperature exhibit excellent separation performance for C2/C3 hydrocarbon mixtures. The separation factors for mixtures of ethane/propane, ethylene/propylene and ethylene/propane are ∼80, ∼10 and ∼167, respectively.
A novel sub-half micron Al-Cu via plug interconnect using low dielectric constant material as inter-level dielectric (1997)

A novel Al-Cu via plug interconnect using low dielectric constant (low-/spl epsiv/) material as inter-level dielectric (ILD) has been demonstrated. The interconnect structure was fabricated by spin-on deposition of the low-/spl epsiv/ ILD and physical vapor deposition (PVD) of the Al-Cu. Excellent local ILD planarization was achieved by a two-step spin-on coating process. The dielectric constant of the low-/spl epsiv/ no is about 2.7, which leads to significant interconnect wiring capacitance reduction. For the first time, completely filled Al-Cu:0.5% plugs with nearly vertical sidewalls were fabricated in organic low-/spl epsiv/ ILD. Excellent via fill was observed with via size down to 0.30 μm. Low via resistance and excellent via reliability have been observed.
Interventions for the interruption or reduction of the spread of respiratory viruses (2007)

Many simple and probably low-cost interventions would be useful for reducing the transmission of epidemic respiratory viruses. Routine long-term implementation of some of the measures assessed might be difficult without the threat of a looming epidemic.
2-Acetylphenylboronic acid monohydrate (2003)

The title compound, C8H9BO3·H2O, displays extensive intermolecular hydrogen bonding of mol­ecules of 2-acetyl­phenyl­boronic acid with each other and with mol­ecules of water, producing infinite, two-dimensional molecular layers. There is no intramolecular hydrogen bonding between the ortho C=O and (HO)2B substituents.
Ultrasonic Attenuation in Vanadium at Low Temperatures (1960)

Longitudinal elastic wave attenuation measurements have been made in a vanadium single crystal in the frequency range of 45 to 435 Mc in both the normal and superconducting states, using pulse echo techniques. Novel experimental features include the use of a superconducting niobium electromagnet (supplied by Stanley H. Autler, Lincoln Laboratory, Massachusetts Institute of Technology). Throughout the frequency range the product ql&amp;lt;&amp;lt;1 where q is the elastic propagation constant and l is the electronic mean free path. The data is in good agreement with the BCS prediction for the ratio of the attenuations in the superconducting and normal states, although this prediction is based on ql&amp;gt;&amp;gt;1. (Supported by Office of Naval Research.)
Oestrogen-induced suppression of collagen arthritis; 17β-oestradiol is therapeutically active in normal and castrated F1 hybrid mice of both sexes (1992)

The F1 hybrid mouse strain, from B10Q and DBA/1 parentals (the QD strain), is highly susceptible to induction of type II collagen-induced arthritis, an experimental model for rheumatoid arthritis. Males are more susceptible than females. Oophorectomy enhances susceptibility to arthritis and treatment with physiological doses of 17 beta-oestradiol (E2) suppresses disease. E2 treatment lowers the incidence of arthritis also in non-castrated and castrated males, showing that the anti-arthritic effect by oestrogen is not dependent on either sex hormone imprinting effects or interference with male sex hormones. Testosterone treatment of normal females, but not of castrated females, exaggerated development of the disease. In the testosterone-treated normal females, the oestrogen effect on vaginal smear was abolished and ovarian weight decreased, suggesting that the testosterone-mediated enhancing effect is caused by inhibition of ovarian oestrogen production. The crucial importance of oestrogens for the development of arthritis is focused on the effectiveness of treatment with gestation-related doses of E2 of normal, non-castrated females.
Targeted α-therapy using astatine (211At)-labeled PSMA1, 5, and 6: a preclinical evaluation as a novel compound (2022)

TAT using [<sup>211</sup>At]PSMA5 resulted in excellent tumor growth suppression with minimal side effects in the normal organs. [<sup>211</sup>At]PSMA5 should be considered a new possible TAT for metastatic CRPC, and translational prospective trials are warranted.
Reduced exercise capacity in untreated adults with primary growth hormone resistance (Laron syndrome) (2003)

Exercise capacity in untreated adults with LS is significantly reduced. The limitation for most patients was not ventilatory but resulted either from low cardiac output and/or from dysfunction of the peripheral muscles. However, the relative contribution of each of these elements and/or the role of poor fitness needs further study.
Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer (2010)

This study is the first to investigate the anticancer effects of the new phloroglucinol derivative (3,6-bis(3-chlorophenylacetyl)phloroglucinol; MCPP) in human colon cancer cells. MCPP induced cell death and antiproliferation in three human colon cancer, HCT-116, SW480, and Caco-2 cells, but not in primary human dermal fibroblast cells. MCPP-induced concentration-dependent apoptotic cell death in colon cancer cells was measured by fluorescence-activated cell sorter (FACS) analysis. Treatment of HCT-116 human colon cancer cells with MCPP was found to induce a number of signature endoplasmic reticulum (ER) stress markers; and up-regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) and glucose-regulated protein (GRP)-78, phosphorylation of eukaryotic initiation factor-2α (eIF-2α), suggesting the induction of ER stress. MCPP also increased GSK3α/β(Tyr270/216) phosphorylation and reduced GSK3α/β(Ser21/9) phosphorylation time-dependently. Transfection of cells with GRP78 or CHOP siRNA, or treatment of GSK3 inhibitor SB216163 reduced MCPP-mediated cell apoptosis. Treatment of MCPP also increased caspase-7, caspase-9, and caspase-3 activity. The inhibition of caspase activity by z-DEVE-FMK or z-VAD-FMK significantly reduced MCPP-induced apoptosis. Furthermore, treatment of GSK3 inhibitor SB216763 also dramatically reversed MCPP-induced GRP and CHOP up-regulation, and pro-caspase-3 and pro-caspase-9 degradation. Taken together, the present study provides evidences to support that GRP78 and CHOP expression, and GSK3α/β activation in mediating the MCPP-induced human colon cancer cell apoptosis.
BiFeO3-doped (Na0.5K0.5)NbO3 lead-free piezoelectric ceramics (2008)

Lead-free piezoelectric ceramics (1−x)(Na0.5K0.5)NbO3-xBiFeO3 (x=0~0.07) were synthesized by the solid-state reaction. Differential scanning calorimetry (DSC) measurements revealed that an increase in the amount of BiFeO3 dopant resulted in a decrease in the orthorhombic-tetragonal and tetragonal-cubic phase transition temperature of the material. One percent BiFeO3 additive suppressed grain growth, which not only benefits the sintering of ceramics but also enhances the piezoelectric and ferroelectric properties, where d33=145pC/N, kp=0.31, Qm=80, Pr=11.3 μC cm−2 and Ec=16.5 kV cm−1. As xBF>0.01, both piezoelectric and ferroelectric properties decreased rapidly with an increasing amount of dopant.