gebhart/patrepeval huggingface dataset:
A redox sensor as a potential regulator of ROS signaling in C. elegans (2013)

Póster presentado en la 19th International Caenorhabditis elegans Meeting, celebrada en Los Ángeles del 26 al 30 de junio de 2013.
Head-Fingers-Arms: Physically-Coupled and Decoupled Multimodal Interaction Designs in Mobile VR (2019)

This paper proposes a novel bimanual finger-based gesture called X-Fingers that provides interactive 2D spatial input control using vision-based techniques in mobile VR. This finger-based input modality can be coordinated with the movement of the user's arms or head to provide an additional input modality. The incorporation of the arms or the head provides physically-coupled and physically-decoupled multimodal interactions respectively. Given these two design options, we conducted user studies to understand how the nature of the physical coupling of interactions influences the user's performance and preferences with task consisting of varying degrees of coordination between the modalities. Our results show that physically-decoupled interactions designs are preferred when the degree of coordination is high within the multimodal interaction.
Split-Fabric: A Novel Wafer-Scale Hardware Obfuscation Methodology using Silicon Interconnect Fabric (2022)

Global manufacturing of integrated circuits provides cost-effective access to high-end fabrication facilities. Offshoring intellectual property (IP) to untrusted foundries, however, makes fab-less design houses vulnerable to several issues, such as reverse engineering, overbuilding, counterfeiting, IP piracy, and insertion of malicious circuits. Several hardware security methodologies and techniques have been proposed in the past few decades to thwart hardware attacks and reduce hardware vulnerabilities.Split-Fabric, a novel wafer-scale hardware security methodology that utilizes the silicon interconnect fabric (Si-IF) technology is proposed in this paper. Split-Fabric is a secure, scalable, low-overhead, and heterogeneous hardware security methodology that supports a fully-untrusted threat model. Two benchmark circuits, a nine-stage ring-oscillator and an 8x8 SRAM array, are designed and fabricated in part using TSMC 65 nm and in part using GF 45 nm to evaluate the performance overhead of Split-Fabric at different levels of obfuscation. According to simulation results, Split-Fabric exhibits orders of magnitude lower obfuscation overhead as compared to the split manufacturing approach.
Human T lymphocyte activation by tumor promoters: role of protein kinase C. (1987)

Protein kinase C (PKC) has a major role in a ligand-receptor-mediated signal transduction system in a variety of cell types including T lymphocytes. One of the early phenotypic changes associated with T cell activation is the expression of cell surface receptors for interleukin 2 (IL 2). To test the role of PKC in regulation of IL 2 receptor (IL 2-R) expression and T cell activation in general, we used tumor promoters (TP) as modulators of PKC and compared their effects on intact human T cells and on the enzymatic activity of T cell-derived PKC in a cellfree system. In T cells, the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) induced IL 2-R expression and proliferation associated with cytosol-to-membrane PKC translocation. A dose of TPA (1 to 4 ng/ml) that induced about 50% of the maximal activation of PKC in the enzymatic assay also induced half-maximal effects on cell proliferation, IL 2-R expression, and PKC redistribution in intact T cells. Structure-function studies with several phorbol ester analogs and non-phorbol ester TP directly correlated tumor promotion activity with the ability to activate PKC and induce IL 2-R. An inhibitor of PKC, chlorpromazine, was found to suppress TPA-mediated proliferation and IL 2-R expression, and inhibited T cell-derived PKC by competing with the phospholipid. Ca2+ ionophore, which synergizes with TPA in induction of T cell proliferation, facilitated the TPA-induced PKC translocation to the membrane. The results thus demonstrate a direct correlation between the effects of various chemicals on: subcellular redistribution of PKC in T cells; induction of T cell proliferation and IL 2-R expression; and activation of T cell-derived PKC in vitro. These data provide further support for the role of PKC in transduction of activation signals in T cells and in regulation of IL 2-R expression.
Assessing Systolic Time-Intervals from Heart Sound: A Feasibility Study (2009)

Systolic time intervals are highly correlated to fundamental cardiac functions. In this paper we investigate the feasibility of using heart sound (HS) to accurately measure the opening and closing moments of the aortic valve, since these are crucial moments to define the main systolic timings of the heart cycle, i.e. the pre-ejection period (PEP) and the left ventricular ejection time (LVET). We introduce a HS model, which is applied to define several features that provide clear markers to identify these moments in the HS. Using these features and a comparative analysis with registered echocardiographies from 17 subjects, the results achieved in this study suggest that HS can be used to accurately estimate LVET and PEP.
Observation of a Shielding Failure to UHV Line (1999)

Lightning strikes have been observed to study the lightning phenomena particular to a system in which both UHV designed and 500kV designed transmission lines coexist. This observation covers the lightning phenomena through lightning strikes, surge propagation on transmission lines and generation of overvoltages in substations. This paper describes the study of the lightning phenomenon of a shielding failure to a UHV designed line and the analysis result by the EMTP, which are based on the observation result of the lightning surge at a substation.
Genetic Variation in Healthy Oldest-Old (2009)

Individuals who live to 85 and beyond without developing major age-related diseases may achieve this, in part, by lacking disease susceptibility factors, or by possessing resistance factors that enhance their ability to avoid disease and prolong lifespan. Healthy aging is a complex phenotype likely to be affected by both genetic and environmental factors. We sequenced 24 candidate healthy aging genes in DNA samples from 47 healthy individuals aged eighty-five years or older (the 'oldest-old'), to characterize genetic variation that is present in this exceptional group. These healthy seniors were never diagnosed with cancer, cardiovascular disease, pulmonary disease, diabetes, or Alzheimer disease. We re-sequenced all exons, intron-exon boundaries and selected conserved non-coding sequences of candidate genes involved in aging-related processes, including dietary restriction (PPARG, PPARGC1A, SIRT1, SIRT3, UCP2, UCP3), metabolism (IGF1R, APOB, SCD), autophagy (BECN1, FRAP1), stem cell activation (NOTCH1, DLL1), tumor suppression (TP53, CDKN2A, ING1), DNA methylation (TRDMT1, DNMT3A, DNMT3B) Progeria syndromes (LMNA, ZMPSTE24, KL) and stress response (CRYAB, HSPB2). We detected 935 variants, including 848 single nucleotide polymorphisms (SNPs) and 87 insertion or deletions; 41% (385) were not recorded in dbSNP. This study is the first to present a comprehensive analysis of genetic variation in aging-related candidate genes in healthy oldest-old. These variants and especially our novel polymorphisms are valuable resources to test for genetic association in models of disease susceptibility or resistance. In addition, we propose an innovative tagSNP selection strategy that combines variants identified through gene re-sequencing- and HapMap-derived SNPs.
Advances in standoff surface contaminant detector platform: developmental test results (2018)

Advances towards the development of a longwave infrared quantum cascade laser (QCL) based standoff and proximal surface contaminant detection platform are presented with emphasis on developmental test results. The detection platform utilizes reflectance spectroscopy with application to optically thick and thin materials in film and particulate forms including solid and liquid phase chemical warfare agents, toxic industrial chemicals and materials, and explosives. The platform employs an ensemble of broadband Fabry-Perot QCLs with a spectrally selective detector to interrogate target surfaces at 1 to 10s of m standoff. A version of a Subspace Adaptive Cosine Estimator is used for detection and discrimination in high clutter environments. Through speckle reduction, a noise equivalent reflectivity of 0.1% was demonstrated enabling detection limits approaching 0.1 &mu;g/cm<sup>2</sup> for optically thin films and 2% fill factor for optically thick particulates. The design, build, and validation of a breadboard version of the QCL-based surface contaminant detector are summarized. Results from developmental testing of contaminated substrates in standoff (5 m range) and proximal (~1 m range) configurations are presented. The test substrates were prepared by the government and Physical Sciences, Inc. and include solid and liquid contaminants at varying surface loadings. Future improvements including an expanded spectral range are discussed.
Novel Synthesis of Methylenecyclobutanols and 4-Methylenetetrahydrofurans from γ-Oxide Ylides (2002)

The reaction of delta-halo-gamma-oxide ylide, prepared from methylenetriphenylphosphorane and epichlorohydrin, with aldehydes afforded alkylidenecyclobutanols in moderate yields. The reaction initially proceeded through internal nucleophilic attack on delta-carbon of this ylide. Another novel approach toward the synthesis of 4-methylenetetrahydrofurans was achieved by the reaction of gamma-oxide ylides with paraformaldehyde.
Diphtheria toxin–mediated ablation of lymphatic endothelial cells results in progressive lymphedema (2016)

Development of novel treatments for lymphedema has been limited by the fact that the pathophysiology of this disease is poorly understood. It remains unknown, for example, why limb swelling resulting from surgical injury resolves initially, but recurs in some cases months or years later. Finding answers for these basic questions has been hampered by the lack of adequate animal models. In the current study, we used <i>Cre-lox</i> mice that expressed the human diphtheria toxin receptor (DTR) driven by a lymphatic-specific promoter in order to noninvasively ablate the lymphatic system of the hind limb. Animals treated in this manner developed lymphedema that was indistinguishable from clinical lymphedema temporally, radiographically, and histologically. Using this model and clinical biopsy specimens, we show that the initial resolution of edema after injury is dependent on the formation of collateral capillary lymphatics and that this process is regulated by M2-polarized macrophages. In addition, we show that despite these initial improvements in lymphatic function, persistent accumulation of CD4<sup>+</sup> cells inhibits lymphangiogenesis and promotes sclerosis of collecting lymphatics, resulting in late onset of edema and fibrosis. Our findings therefore provide strong evidence that inflammatory changes after lymphatic injury play a key role in the pathophysiology of lymphedema.
Applied decision making with fast-and-frugal heuristics. (2016)

In applied settings, such as aviation, medicine, and finance, individuals make decisions under various degrees of uncertainty, that is, when not all risks are known or can be calculated. In such situations, decisions can be made using fast-and-frugal heuristics. These are simple strategies that ignore part of the available information. In this article, we propose that the conceptual lens of fast-and-frugal heuristics is useful not only for describing but also for improving applied decision making. By exploiting features of the environment and capabilities of the decision makers, heuristics can be simple without trading off accuracy. Because decision aids based on heuristics build on how individuals make decisions, they can be adopted intuitively and used effectively. Beyond enabling accurate decisions, heuristics possess characteristics that facilitate their adaptation to varied settings. These characteristics include accessibility, speed, transparency, and cost effectiveness. Altogether, the article offers an overview of the literature on fast-and-frugal heuristics and their usefulness in diverse applied settings.
Predictors of Success After Furlow Palatoplasty for Repair of Cleft Palate: Does Syndrome Matter? (2021)

Objective To determine predictors of success following Veau 1 and 2 cleft palate repair in patients with and without syndromes. Study Design Retrospective review of prospectively collected data. Setting Tertiary care children’s hospital. Methods All children &lt;18 months of age undergoing Furlow palatoplasty for Veau 1 and 2 cleft repair between 2000 and 2014 with postoperative perceptual speech assessment (PSA). Results In total, 368 consecutive patients were identified; 95 were excluded, resulting in 273 patients. Median age at surgery was 13.0 months (interquartile range [IQR], 11‐15 months) with postoperative PSA at a median of 32.3 months (IQR, 26.3‐44.5 months). Fifty patients (18.3%) had syndrome diagnosis; 59 patients (21.6%) had nonsyndromic Robin sequence. Velopharyngeal insufficiency (VPI) occurred in 27 patients (10.5%); 13 underwent secondary speech surgery. Cleft‐related speech errors occurred in 46 patients (17.6%). Non‐cleft‐related speech errors occurred in 155 patients (59.6%) and reduced intelligibility in 127 patients (47.9%). Oronasal fistula occurred in 23 patients (8.8%) and was exclusive to Veau 2 clefts. In multivariate analysis, age &gt;13 months at palatoplasty demonstrated a 6‐fold higher rate of VPI (hazard ratio [HR], 6.64; P &lt;. 01), worse speech outcomes (HR, 6.04; P &lt;. 01; HR, 1.60; P &lt;. 01; HR, 1.57; P =. 02), and greater speech therapy utilization (HR, 2.18; P &lt;. 01). Conclusion VPI occurred in 10% of patients undergoing Furlow palatoplasty repair of Veau 1 or 2 clefts. Age &lt;13 months at palatoplasty was associated with improved speech outcomes and lower VPI incidence (2.8% vs 16.2%). Syndromic diagnosis was associated with noncleft speech errors and reduced intelligibility on univariate analysis but not velopharyngeal function after palatoplasty.
A universal framework for managing metadata in the distributed Dragon Slayer system (2002)

In the multimedia field, metadata are becoming increasingly important for efficiently cataloguing the abundant flood of information. (Metadata are data on information structures.) The number of electronic data files made accessible by metadata increases rapidly, however at the present retrieving textual, audio, video and/or mixed data files through metadata is definitely restricted. In particular, there is only a limited number of metadata formats at hand. Nevertheless, within the framework of testbeds, some efforts have been made not only to develop retrieval systems adjusted to the respective field of application, but also to unite several metadata formats into one system in order to obtain better search results. This paper describes specifications for developing an attribute service which, as part of the "Dragon Slayer" distributed file system, is intended to offer a uniform platform for different metadata formats, and to offer efficient information metadata retrieval. Via the interface provided by the Dragon Slayer file system, the user can assign metadata to files and reference them via these metadata. For each metadata format used, an external meta module is incorporated into the file system which, depending on its format, manages and searches for metadata in a database, according to their format.
Cyclization reactions of chromium dienylcarbene complexes. Entry to ortho-substituted aromatic alcohols via a designed photoreaction (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclization reactions of chromium dienylcarbene complexes. Entry to ortho-substituted aromatic alcohols via a designed photoreactionCraig A. Merlic and Daqiang XuCite this: J. Am. Chem. Soc. 1991, 113, 19, 7418–7420Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/ja00019a047https://doi.org/10.1021/ja00019a047research-articleACS PublicationsRequest reuse permissionsArticle Views398Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Quantifying manganese in lymphocytes to assess manganese nutritional status. (1989)

To clarify whether manganese nutritional status is better reflected by the manganese concentration in lymphocytes or in whole blood, we injected manganese solutions intravenously into manganese-deficient rats and determined manganese concentrations in lymphocytes, whole blood, and various tissues. The manganese concentrations in lymphocytes and tissues, but not in whole blood, were significantly less in manganese-deficient rats than in normal rats. These low values could be prevented by intravenous injection of manganese in a dose-dependent manner. These results suggest that, for assessment of manganese nutritional status, measurement of manganese in lymphocytes is better than that in whole blood.
Optimization of the Schiff bases of N-hydroxy-N'-aminoguanidine as anticancer and antiviral agents (1985)

Hydroxyurea, hydroxyguanidine, and some thiosemicarbazones have been shown to have anticancer and antiviral activities. One of their possible sites of action is the enzyme ribonucleotide reductase (RR). Combination of the structural features of these compounds led to the design and synthesis of the Schiff bases of N-hydroxy-N'-aminoguanidine. Synthesis and structure-activity studies of some of these compounds point to increased size and lipophilicity as important factors for activity. To optimize the activities of this series of compounds, 13 derivatives of high lipophilicity and molecular size have been synthesized and their biological activities studied. The most active anticancer compounds against L1210 in vitro (compounds 9 and 12) are about 7 times more active than hydroxyguanidine and hydroxyurea. The most active antiviral compounds against Rous sarcoma virus transformation of chick fibroblasts in vitro (7, 9) are about 40 times more active than hydroxyguanidine. One of the compounds (4) shows promising activity in vivo (% T/C = 140 against P388 leukemia in mice) and is undergoing further studies by the National Cancer Institute (NCI). Studies of the inhibition of transformation of chick embryo cells by Rous sarcoma virus show that all these compounds inhibit transformation while some compounds inhibit viral replication as well.
Body Mass Bias And Allometric Scaling In The Army Physical Fitness Test Among Infantry Soldiers (2009)

Previous research has reported that body mass is negatively correlated with performance in the APFT which includes push up (PU), sit-up (SU) and 2-mile run (RUN) events. Vanderburgh et al., (Med Sci Sports Exerc 40:1538, 2008) reports that these relationships result in a significant bias against larger individuals. By reducing the correlation between body mass and scaled scores, allometric scaling has been suggested as a means to reduce body mass bias in these tests. PURPOSE: To determine the relationship between body mass and lean body mass and APFT performance, and to evaluate the effectiveness of allometric scaling in a sample of active duty soldiers. METHODS: 187 Infantry soldiers (23±5 yrs) were measured for body composition using dual energy x-ray absorptiometry. They performed the APFT consisting of completing the maximum number of PU in two minutes, maximum number of SU in two minutes and running two-miles as fast as possible. Allometric scaling was achieved by multiplying APFT raw scores for PU and SU by body mass1/3 and multiplying RUN time by body mass-1/3 (kg). RESULTS: SU were not significantly correlated to total body mass (r=-0.11) or lean body mass (r=-0.02). There was a slight negative correlation between PU and body mass (r=-0.23, p=0.01) but none between PU and lean body mass (r=-0.10). There were significant correlations between RUN and total body mass (r=0.37, p<0.01) as well as lean body mass (r=0.17, p<0.01). Allometric scaling resulted in greater correlations between body mass and lean body mass with SU (r=0.26 and r=0.31, respectively p<0.01) and RUN (r=-0.34 and r=-0.48, respectively p<0.01), increasing body mass bias in these measures. After allometric scaling, PU was no longer correlated with body mass or lean body mass (r=0.03, r=0.13). CONCLUSION: The Army does not correct for body size in scoring APFT events. In trained Infantrymen, allometric scaling did not reduce the correlation between body size measures and either SU or RUN. However, a body mass1/3 correction for push-ups appears warranted since allometric scaling eliminated body mass bias from PU performance.
Muscle structure and gene expression in pectoralis major muscle in response to deep pectoral myopathy induction in fast- and slow-growing commercial broilers (2018)

1. The objective of this study was to determine muscle structure and gene expression in <i>pectoralis major (p. major)</i> muscle of broilers in response to deep pectoral myopathy (DPM) induction. 2. A total of 160 chickens from slow- and fast-growing broilers were raised under same conditions. Half of the broilers from each strain were encouraged to wing flap when they reached 2800 g body weight. <i>Pectoralis minor (p. minor)</i> muscle of the broilers was inspected for the occurrence of DPM and <i>p. major</i> samples were collected from broilers with or without DPM. The muscle fibre area and number, capillary number and the signalling pathways of vascular development (vascular endothelial growth factor A, <i>VEGFA</i>) and muscle contraction regulation (<i>actin alpha 1, ACTA1; myosin light chain kinase 2, MYLK2 and ATPase Ca<sup>+2</sup> transporting gene 1, ATP2A1</i>) were studied in <i>p. major</i> muscle. 3. DPM induction increased fibre area of <i>p. major</i> muscle with a greater rate in the slow-growing strain compared with fast-growing line. Although the capillary number was higher in slow-growing compared with fast-growing broilers, in the case of DPM induction, the number of capillaries was similar between strains. 4. Expression of <i>VEGFA, MYLK2</i> and <i>ATP2A1</i> was greater in slow- than in fast-growing broilers. DPM induction increased expression of <i>ACTA1, VEGFA</i> and <i>ATP2A1</i> in <i>p. major</i> muscle of broilers from both strains; however, <i>MYLK2</i> expression was downregulated. 5. Changes in capillary density and expression of <i>VEGFA</i> found in the <i>p. major</i> muscle of broilers with DPM suggest increased blood flow to increase oxygen availability. The upregulation of <i>ATP2A1</i> by DPM induction could be attributable to alterations in calcium ion transportation from the cytoplasm into the sarcoplasmic reticulum. 6. The results are evidence of changes in muscle structure and gene expression pathways in <i>p. major</i> muscle of broilers with DPM.