gebhart/patrepeval huggingface dataset:
Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse (2017)

Alzheimer's disease (AD) is rarely addressed in the context of aging even though there is an overlap in pathology. We previously used a phenotypic screening platform based on old age-associated brain toxicities to identify the flavonol fisetin as a potential therapeutic for AD and other age-related neurodegenerative diseases. Based on earlier results with fisetin in transgenic AD mice, we hypothesized that fisetin would be effective against brain aging and cognitive dysfunction in rapidly aging senescence-accelerated prone 8 (SAMP8) mice, a model for sporadic AD and dementia. An integrative approach was used to correlate protein expression and metabolite levels in the brain with cognition. It was found that fisetin reduced cognitive deficits in old SAMP8 mice while restoring multiple markers associated with impaired synaptic function, stress, and inflammation. These results provide further evidence for the potential benefits of fisetin for the treatment of age-related neurodegenerative diseases.
A concatenating coding scheme employing pragmatic multidimensional trellis code and RS code for satellite communication (2002)

In this paper, a concatenating coding scheme is proposed for satellite communication, which employs an inner trellis code and RS outer codes. The inner code is a rate 5/6 4-dimensional 8 PSK trellis code based on Viterbi's pragmatic coding idea. The outer codes are RS(255,239) and NASA standard RS(255,223) codes, respectively. Performance is evaluated by an analytical method and computer simulations under an ideal linear AWGN channel. The complexity and the performance of the considered coding scheme are compared with the same rate optimal four dimensional trellis code and punctured.
In vivosiRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates Concanavalin A-induced acute liver injury in mice (2014)

Oxidative stress contributes to the progression of acute liver failure (ALF). Transcription factor nuclear factor-erythroid 2-related factor (Nrf2) serves as an endogenous regulator by which cells combat oxidative stress. We have investigated liver damage and the balance between death and survival signaling pathways in concanavalin A (ConA)-mediated ALF using in vivo siRNA delivery targeting Keap1 in hepatocytes. For that goal, mice were injected with Keap1- or luciferase-siRNA-containing liposomes via the tail vein. After 48 hours, ALF was induced by ConA. Liver histology, pro-inflammatory mediators, antioxidant responses, cellular death, and stress and survival signaling were assessed. Keap1 mRNA and protein levels significantly decreased in livers of Keap1-siRNA-injected mice. In these animals, histological liver damage was less evident than in control mice when challenged with ConA. Likewise, markers of cellular death (FasL and caspases 8, 3 and 1) decreased at 4 and 8 hours post-injection. Nuclear Nrf2 and its target, hemoxygenase 1 (HO1), were elevated in Keap1-siRNA-injected mice compared with control animals, resulting in reduced oxidative stress in the liver. Similarly, mRNA levels of pro-inflammatory cytokines were reduced in livers from Keap1-siRNA-injected mice. At the molecular level, activation of c-jun (NH2) terminal kinase (JNK) was ameliorated, whereas the insulin-like growth factor I receptor (IGFIR) survival pathway was maintained upon ConA injection in Keap1-siRNA-treated mice. In conclusion, our results have revealed a potential therapeutic use of in vivo siRNA technology targeted to Keap1 to combat oxidative stress by modulating Nrf2-mediated antioxidant responses and IGFIR survival signaling during the progression of ALF.
19세기 조선(朝鮮)에서의 단옥재(段玉裁) 학문에 대한 인식 및 『설문해자주(說文解字注)』 수용 양상 (2011)

본고는 淸代 문자학·음운학·고증학의 대표적인 학자인 段玉裁와 그의 『說文解字注』가 19세기 조선 학계에서 어떻게 인식되고 수용되었는지에 대해 살펴보는 것을 연구의 목적으로 하였다. 이에 따라, 본론에서는 金正喜를 중심으로 하여 19세기 조선 學人들의 단옥재 학문에 대한 인식과 평가에 대해 살펴보았으며, 이어서 한국 문집 및 경학자료에서 『설문해자주』를 직접 인용하고 활용한 내용에 대해 살펴보았다. 본 연구를 통해 다음과 같은 사항을 확인할 수 있었다. 첫째, 19세기 조선에서 段玉裁의 학문에 대해 가장 객관적이고 비판적인 평가를 진행했던 인물은 金正喜이다. 그는 단옥재의 학문이 엄격하고 정밀하였으며 음운학에 성과가 있었음을 인정하면서, 한편으로 단옥재의 학문이 存古的인 측면에 固滯된 면이 있었다고 하였고 단옥재의 문자 해석을 비판하기도 하였다. 이를 통해, 김정희가 단옥재의 학문을 비롯한 淸代 고증학의 학문적 동향을 잘 이해하고 있었음을 알 수 있다. 둘째, 1807년에 집필이 완성되고 1815년 5월에 출판된 段玉裁의 『說文解字注』가 조선에 유입된 시기는 金正喜의 「與李月汀璋煜」을 통해서 확인할 수 있다. 한국 문집과 경학자료를 검토해 보면 『설문해자주』를 직접 인용한 것은 김정희의 「與李月汀璋煜」이 처음으로 여겨진다. 이 글은 1827년 또는 1828년에 쓰여진 것이므로, 단옥재의 『설문해자주』가 조선에 유입된 시기는 1827년 이전일 것으로 추정할 수 있다. 셋째, 19세기 조선의 學人들 중에서 『說文解字注』를 직접 인용한 인물은 金正喜, 許傳, 李裕元, 張之琬 등을 들 수 있다. 이들은 『설문해자주』를 활용하여 글자 해석과 名物 고증 및 경서 구절에 대한 검토를 진행하였으며, 특히 金正喜는 『설문해자주』에 보이는 段玉裁 注의 내용에 대해 비판을 가하기도 하였다. 넷째, 19세기 조선 학계에서의 段玉裁 학문에 대한 인식 및 『說文解字注』의 수용 양상을 살펴보면, 당시에 『설문해자주』가 크게 유행되지 않았으며 그 영향도 크지 않았던 것으로 보인다. 이는 조선의 학풍이 淸朝와 달리 小學(文字·聲韻·訓고)을 학문의 중심으로 삼지 않았다는 점, 또 조선에서 小學을 전문적으로 연구하는 학자들이 많지 않았다는 점 등의 영향이었을 것으로 추정된다.
Nickel coated graphite fiber conductive composites (1986)

During the past few years, a number of studies reported that different melanoma cell lines could be extensively lysed in vitro by IL-2-activated NK cells at appropriate effector/target ratios. Here, we show, by histological evaluation of different melanoma lesions, that NK/target-cell ratios compatible with those allowing efficient melanoma cell killing in vitro are hardly reached at the tumor site. We then investigated the outcome of cocultures established at low NK/melanoma cell ratios. After initial NK-mediated lysis, residual melanoma cells acquired resistance to IL-2-activated NK cells. This reflected primarily an increased expression, on melanoma cells, of classical and nonclassical HLA class I molecules, accompanied by a partial downregulation of NKG2D-ligands, and was dependent on NK-mediated IFN-γ release. Consistently, melanoma lesions showed a higher HLA class I expression on tumor cells that were proximal to infiltrating NK cells. In long-term cocultures, the "protective phenotype" acquired by melanoma cells was lost over time. However, this phenomenon was counteracted by downregulation of relevant activating receptors in cocultured NK cells. Analysis of different NK-cell-activating cytokines indicated that IL-15 can partially overcome this novel tumor escape mechanism suggesting that IL-15, rather than IL-2, may be eligible for NK-cell-based immunotherapy.
A 55-V, 0.2-m Omega -cm/sup 2/ vertical trench power MOSFET (1991)

Experimental results that demonstrate trench power MOSFETs with a specific on-state resistance of 0.2 m Omega -cm/sup 2/ and capable of sustaining 55 V across drain-source terminals in the off state are discussed. This performance was achieved by using an improved silicon trench processing technology. The forward conductivity reported is the highest ever obtained for a silicon power device.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Modelling trust in random wireless networks (2014)

We present an analysis of the probability that a set of devices capable of communicating wirelessly can form a fully connected, trusted network. The network model that is used accounts for the geometric properties of the physical network boundaries, the statistical nature of the propagation environment, and the notion that both trustworthy and untrustworthy devices may occupy the network domain. Two local (pairwise) trust models are explored in the context of this model: proximity-based trust, where trust between two devices is a function of the distance between them, and experience-based trust, where trust is dependent upon the outcomes from prior inter-device interactions. Both models are probabilistic, a condition that is motivated by our interest in the steady state or average behaviour of the network as well as several practical applications, including sensor and device-to-device (D2D) networks for disaster relief, public safety, and peer-to-peer file sharing in 5G cellular systems. Our analysis illustrates a clear and simple mathematical relationship between the local trust probabilities and the underlying physics of the system, thus pointing to a need for trust protocols that are tailored to specific deployments.
Communication—Electropolymerization of Anion-Conducting Polymer Films (2022)

We successfully electropolymerize homopolymer and copolymer from vinylbenzyltrimethylammonium chloride (VBTMA) and divinylbenzene (DVB) by cyclic voltammetry to form ultra-thin anion-conducting polymer films with significant anion conductance. The morphologies of electropolymerized polymers with different monomer compositions are analyzed by scanning electron microscopy (SEM) and atomic force microscopy (AFM). In-situ electrochemical impedance spectroscopy (in situ EIS) is performed to track the electropolymerization (EP) process and film properties. High anion conductance of up to 2 mS is found in the electropolymerized thin films, suggesting that this technique can be suitable for making anion-conducting electrodes for advanced electrochemical devices.
Synthese asymetrique de derives de l'histrionicotoxine et de spiropiperidines apparentees (1991)

Nous presentons dans une premiere partie une nouvelle voie d'acces a la synthese asymetrique des 1,2-diamines chirales. Elle est basee sur l'addition chimioselective des organolithiens ou organocuprates sur le synthon 2-cyano-6-phenyloxazolo-piperidine pour conduire a une imine intermediaire qui apres reduction permet l'acces aux differentes 1,2-diamines chirales. Ce resultat a ete applique a la synthese asymetrique d'un analogue de la tetraponerine. La deuxieme partie de cette these concerne la synthese asymetrique d'une nouvelle structure 1,8-diazaspiro (5,5) undecane qui presente un squelette hybride entre ceux de l'histrionicotoxine et des alcaloides du genre nitraria. Trois voies differentes ont ete developpees permettant la synthese de cinq composes dans cette seie, qui different par la presence des chaines laterales, ainsi que par la stereochimie des carbones qui les portent. Les configurations relatives et absolues des composes prepares ont ete determinees par des analyses conformationnelles et par des etudes approfondies en rmn du #1h (cosy, #1h-#1h, noe-diff, noesy) et du #1#3c (cosy #1#3c-#1h, coloc). Malgre les nombreux travaux existant dans la litterature sur la synthese de la ()-perhydrohistrionicotoxine (phtx), il n'existe que peu de resultats en serie optiquement active. Nous avons realise, dans la troisieme partie, une synthese asymetrique de la (-)-depentyl-phtx, ainsi que la (-)-2-epi-phtx en 13 et 12 etapes respectivement. Une aldolisation intramoleculaire a ete exploitee pour conduire le squelette azaspirannique
A 17-kD centromere protein (CENP-A) copurifies with nucleosome core particles and with histones (1987)

We have detected and begun to characterize a 17-kD centromere-specific protein, CENP-A (Earnshaw, W. C., and N. Rothfield, 1985, Chromosoma., 91:313-321). Sera from several humans with CREST scleroderma autoimmune disease (CREST: calcinosis, Raynaud's phenomenon, esophageal dsymotility, sclerodactyly, and telangiectasia) bind this protein in immunoblot assays of HeLa whole cell or nuclear extracts. We have affinity purified the anti-17-kD centromere protein (anti-CENP-A) specific antibodies from immunoblots of HeLa nuclear protein. The antibodies react with epitopes present on CENP-A derived from humans but apparently do not recognize specific epitopes in either rat or chicken nuclei. Only human nuclear protein is CENP-A positive by immunoblot. Furthermore, human cells show localization of anti-CENP-A antibody to centromeres by immunofluorescence microscopy, whereas rat cells do not. On extraction from the nucleus, CENP-A copurifies with core histones and with nucleosome core particles. We conclude that this centromere-specific protein is a histone-like component of chromatin. The data suggest that CENP-A functions as a centromere-specific core histone.
Adversarial Learning Approach to Unsupervised Labeling of Fine Art Paintings (2021)

An automatic classification of fine art images is limited by the scarcity of high-quality labels made by art experts. This study aims to provide meaningful automatic labeling of fine art paintings (machine labeling) without the need for human annotation. A new unsupervised Adversarial Clustering System (ACS) is proposed. The ACS is an adversarial learning approach comprising an unsupervised clustering module generating machine labels and a supervised classification module classifying the data based on the machine labels. Both modules are linked through an optimization algorithm iteratively improving the unsupervised clusters. The objective function driving the improvement consists of the within-cluster sum of squares (WCSS) error and the supervised classification accuracy. The proposed method was tested on three different fine-art datasets, including two sets of paintings previously categorized by art experts and one never categorized collection of Australian Aboriginal paintings. The unsupervised clusters were analyzed using standard unsupervised clustering metrics and a reliability measure between machine and human labeling. The ACS showed higher reliability compared to the classical k-means clustering method. The content analysis of unsupervised clusters indicated grouping based on scene composition, type, and shape of the object, edge sharpness and direction, and color palette.
Risk Sensitive Markov Decision Processes (1997)

Risk-sensitive control is an area of significant current interest in stochastic control theory. It is a generalization of the classical, risk-neutral approach, whereby we seek to minimize an exponential of the sum of costs that depends not only on the expected cost, but on higher order moments as well.
A GMDH-type neural network with multi-filter feature selection for the prediction of transition temperatures of bent-core liquid crystals (2016)

The QSPR study on transition temperatures of five-ring bent-core LCs was performed using GMDH-type neural networks. A novel multi-filter approach, which combines chi square ranking, v-WSH and GMDH algorithm was used for the selection of descriptors.
Reply : Pupil dilation with intracameral lidocaine during phacoemulsification (2007)

We thank Drs. Jayadev and Nayak for their critical analysis of our recent paper. As we mentioned in our article, preservative-free lidocaine was reported to be safe for intracameral injection.1–3 We measured the pupil diameters on the surface of the cornea. Since the measurement method was the same in both groups, we did not consider the magnification factor. We tried to minimize the parallax error using a caliper with the smallest available units (0.5 mm scales), asking the patient to look straight ahead at the coaxial operating microscope light, centering the corneal light reflex, and repeating the same measure 3 times to get a good mean value. The measurements were performed by the same surgeon in all cases.
Developing Luminescent Ratiometric Thermometers Based on a Covalent Organic Framework (COF) (2019)

Abstract Covalent Organic Frameworks (COFs), an emerging class of crystalline porous materials, are proposed as a new type of support for grafting lanthanide ions (Ln 3+ ) and employing these hybrid materials as ratiometric luminescent thermometers. A TpBpy‐COF—prepared from 1,3,5‐triformylphloroglucinol (Tp) and 2,2′‐bipyridine‐5,5′‐diamine (Bpy) grafted with Eu/Tb and Dy acetylacetone (acac) complexes can be successfully used as a luminescent thermometer in the 10–360 K (Eu) and 280–440 K (Tb) ranges with good sensing properties (thermal sensitivity up to 1.403 % K −1 , temperature uncertainty δ T &lt;1 K above 110 K). For the Eu/Tb systems, we observe an unusual and rarely reported behavior, that is, no thermal quenching of the Tb 3+ emission, a result of the absence of ion‐to‐ligand/host energy back‐transfer. The LnCOF materials proposed here could be a new class of materials employed for temperature‐sensing applications following up on the well‐known luminescent metal–organic framework thermometers.
Facilitation of displacements at the 6-position of purines by the use of 1,4-diazabicyclo[2.2.2]octane as leaving group (1997)

Reactions of 6-chloropurines with 1,4-diazabicyclo[2.2.2]octane (DABCO) give the corresponding ‘DABCO-purines’ 1a–d, which undergo facile displacement reactions with alkoxides in dimethyl sulfoxide to afford 6-oxy-substituted purines.
Noise characteristics of GaInP/GaAs HBT at 29 GHz (1998)

A characterization of bias and emitter periphery-to-area ratio (Pe/Ae) of GaInP/GaAs HBT at 29 GHz is presented. The measured data of fmax, ft, Fmin, associated gain (Ga) and noise measure (NM) for four transistors were obtained. It is shown that the larger periphery-to-area ratio of the emitter, Pe/Ae, the lower the Fmin with a minimum. The best transistor, an array of twenty 2×2 μm2, had Fmin=2.81 dB, Ga = 4.9dB and NM=1.35.
Development of KMo supported catalysts on alumina for the direct synthesis of methylmercaptanfrom syngas and H2S (2019)

International audience
Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism (2011)

Evidence is presented for a role for progranulin as a novel growth factor regulating cholangiocarcinoma growth. Specific targeting of progranulin may represent an alternative for the development of therapeutic strategies.
The Application and Control Optimization of Electronic Park Brake in the Park Assist (2016)

In order to improve vehicle active safety, friction work of brake and jerk intensity are selected as the indexes to evaluate the brake process quality, the dynamic characteristics of transmission system composed by engine, hydraulic torque converter and drive shaft, are analyzed in the parking process. Based on the calculus of variations, by taking the rate of brake torque as the control variable, the weighted sum of the friction work and the square of control variables is served as the objective function which is proposed for the optimal process control. Through the solution of the optimization function with boundary constrains, the optimized vehicle speed curve used as the reference speed is obtained, the deviation between the reference speed and the actual speed acquired by wheel speed sensor is fed back to EPB (Electrical Park Brake), forming closed loop control. The simulation result on the platform (MATLAB /Simulink) exhibits that the vehicle securely parking within a certain time and distance. By means of the measuring the related parameters of the test car, the optimal speed curves of parking course are received. The test result verifies the feasibility of the control strategy.
Effect of permeation through stator on the hydrodynamics of a rotating disk dynamic filter. (1988)

Fluid flow between a rotating disk and a stationary septum such as that in a rotating disk dynamic filter was studied theoretically and experimentally. The Navier-Stokes equations were solved in the laminar flow region of Re〈104 under reasonable fluid permeation rates through the stationary disk. The velocity profiles obtained by numerical calculation agree very well with the results determined by LDA measurement. Distributions of shear stress acting on the rotating disk and stationary septum are also presented in this study.
Development of a positive psychology intervention for patients with acute cardiovascular disease (2011)

The management of depression and other negative psychological states in cardiac patients has been a focus of multiple treatment trials, though such trials have not led to substantial improvements in cardiac outcomes. In contrast, there has been minimal focus on interventions to increase positive psychological states in cardiac patients, despite the fact that optimism and other positive states have been associated with superior cardiovascular outcomes. Our objective was to develop an 8-week, phone-based positive psychology intervention for patients hospitalized with acute cardiac disease (acute coronary syndrome or decompensated heart failure). Such an intervention would consist of positive psychology exercises adapted for this specific population, and it would need to be feasible for practitioners and patients in real-world settings. By adapting exercises that were previously validated in healthy individuals, we were able to generate a positive psychology telemedicine intervention for cardiac patients that focused on optimism, kindness, and gratitude. In addition, we successfully created a companion treatment manual for subjects to enhance the educational aspects of the intervention and facilitate completion of exercises. Finally, we successfully performed a small pilot trial of this intervention, and found that the positive psychology intervention appeared to be feasible and well-accepted in a cohort of patients with acute cardiac illness. Future studies should further develop this promising intervention and examine its impact on psychological and medical outcomes in this vulnerable population of cardiac patients.
Zero-field steps and coherent emission of externally heated long Josephson junctions (2016)

IV-characteristics of stacks of two inductively interacting long Josephson junctions with the homogeneous and inhomogeneous distributions of critical currents were investigated numerically. It was assumed that the inhomogeneous linear distribution of critical currents along the junction was created by heating of one end of the stack. Even zero-field steps were found in the IV-curve of the stack with the homogeneous distribution of critical currents, whereas odd zero-field steps appeared in the IV-curve of the stack with the heated end. Due to the inductive interaction between junctions in a stack of two junctions, each of the zero-field steps splits into two steps which correspond to frequencies of collective excitations in the system. Strong coherent emission was found at the step which corresponds to the frequency of in-phase oscillations.
Time-dependent electron tunneling through parabolic quantum wells (1992)

The time-dependent tunneling of electron wave packets through parabolic quantum wells is numerically studied. We consider both true smooth parabolic wells and quasiparabolic short-period superlattice potentials. The evolution of the charge density is described in detail. The electron dwell time at various resonance energies is also calculated.