gebhart/patrepeval huggingface dataset:
Open Architecture Submarine Cable Observatory Systems (2007)

The NEPTUNE observatory system has introduced a new technology approach, bringing the Internet to subsea cabled science observatory systems. The subsea nodes, providing subsea connection points provisioning data and power, provide a gateway between the permanent infrastructure and the instrumentation. The proven high reliability and long life of the subsea communications equipment offers the opportunity to install permanent observatories for operation for at least 25 years. This technology provides as a flexible system with many key features that provide a new horizon for future observatory needs. The provision of standard, open, connection interfaces to the instrumentation systems simplifies the overall development and integration of new instrumentation. The provision of high bandwidth enables all data to be readily communicated to shore with excellent time resolution. Compared to conventional systems the availability of much higher power, up to 10 kW per node, will enable a new generation of instrumentation systems to be deployed. The paper will describe a ring architecture for a Regional Cabled Observatory, and scope the expansion, via a number of methods, to provide greater physical coverage. Some key, architectural options for subsea cable observatories will be considered, for coastal (<100 km) and longer, regional systems. The paper will also report on the development of the new products for the Neptune Science Observatory.
Improving the Efficiency of the Trent 500-HP Turbine Using Nonaxisymmetric End Walls—Part I: Turbine Design (2003)

This paper describes the redesign of the HP turbine of the Rolls-Royce Trent 500 engine, making use of nonaxisymmetric end walls. The original, datum turbine used conventional axisymmetric end walls, while the vane and (shrouded) rotor aerofoil profiles were nominally the same for the two designs. Previous research on the large-scale, low-speed linear cascade at Durham University (see Hartland et al., 1998, “Non-Axisymmetric End Wall Profiling in a Turbine Cascade,” ASME 98–GT-525), had already demonstrated significant potential for reducing turbine secondary losses using nonaxisymmetric end walls-by about one third. This paper shows how a methodology was derived from the results of this research and applied to the design of the single-stage Trent 500-HP turbine (model rig). In particular, the application of a new linear design system for the parametric definition of these end wall shapes (described in Harvey et al., 1999, “Non-Axisymmetric Turbine End Wall Design: Part I Three-Dimensional Linear Design System,” ASME 99–GT-337) is discussed in detail.
Transparency of band-gap-shifted InGaAsP/lnP quantum-well waveguides (1996)

The properties of band-gap-shifted InGaAsP/InP quantum-well waveguides were investigated. A 90 nm blue-shift of the band gap was obtained by phosphorus ion implantation followed by rapid thermal annealing. It was shown that the absorption constant at the original band edge was reduced from 110 to only 4 cm −1 . No waveguide excess loss was observed due to the QW-intermixing process. Good electrical properties of the pin diode were also maintained.
Synthesis of labelled N‐(4‐hydroxy‐[14C(U)]phenyl)‐2‐[2,3‐dihydro‐3‐oxo‐l,2‐benzisothiazol‐2‐yl‐1,1‐dioxide]acetamide (2005)

Abstract The amidation of 2‐[1,1‐dioxide‐3‐oxo‐1,2‐benzisothiazole‐2(3H)‐yl] acetyl chloride with carbon‐14‐labelled 4‐amino‐[ 14 C(U)]phenol in NaOAc‐HOAc buffer solution at −10°C gave N ‐(4‐hydroxy‐[ 14 C(U)]phenyl)‐2‐[2,3‐dihydro‐3‐oxo‐1,2‐benziso‐thiazol‐2‐yl‐1,1‐dioxide]acetamide in 82% yield. Subsequent hydrolysis with aqueous 0.5 N NaOH solution afforded the ring opened product N ‐(4‐hydroxy‐[ 14 C(U)]‐phenyl)‐2‐[2‐carboxy‐phenylsulfonamido]acetamide in 80% yield. Copyright © 2005 John Wiley &amp; Sons, Ltd.
Sphingosine Kinase: Biochemical and Cellular Regulation and Role in Disease (2006)

Sphingolipids have emerged as molecules whose metabolism is regulated leading to generation of bioactive products including ceramide, sphingosine, and sphingosine-1-phosphate. The balance between cellular levels of these bioactive products is increasingly recognized to be critical to cell regulation; whereby, ceramide and sphingosine cause apoptosis and growth arrest phenotypes, and sphingosine-1-phosphate mediates proliferative and angiogenic responses. Sphingosine kinase is a key enzyme in modulating the levels of these lipids and is emerging as an important and regulated enzyme. This review is geared at mechanisms of regulation of sphingosine kinase and the coming to light of its role in disease.
Supplementary Figure 1 from Resuscitating Cancer Immunosurveillance: Selective Stimulation of DLL1-Notch Signaling in T cells Rescues T-cell Function and Inhibits Tumor Growth (2023)

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The Metabolic Phenotype of Prader-Willi Syndrome (PWS) in Childhood: Heightened Insulin Sensitivity Relative to Body Mass Index (2010)

The heightened insulin sensitivity of PWS patients relative to OCs is associated with higher levels of adiponectin and lower levels of high-sensitivity C-reactive protein and IL-6. Future studies will determine whether PWS children are protected from obesity comorbidities such as type 2 diabetes, hyperlipidemia, and nonalcoholic fatty liver disease.
Propofol neuroprotection in a rat model of ischaemia reperfusion injury (1997)

This study was designed to test the hypothesis that propofol, which possesses antioxidant properties, would produce greater protection than isoflurane in cerebral ischaemia reperfusion injury, at dose levels that produced similar affects on brain electrical activity. Twenty Sprague-Dawley rats were anaesthetized using isoflurane 1.5% in air/oxygen, and mechanically ventilated to a PaCO2 of 4.5 kPa. Following 90 min of middle cerebral artery occlusion using an intraluminal filament, rats were given, in random order, either propofol 1 mg kg-1 min-1 or isoflurane 3% (both of which have been shown to reliably produce EEG burst suppression). After a further 30 min, reperfusion was induced by withdrawing the filament. Animals were killed following 240 min of reperfusion. Rats in the propofol group showed a 21% reduction in mean hemispheric infarct volume when compared with the isoflurane group (P < 0.0001). These data suggest that propofol may act by mechanisms in addition to CMRO2 depression, and provide a basis for further studies of propofol neuroprotection.
Message-Passing Algorithms for Sparse Network Alignment (2013)

Network alignment generalizes and unifies several approaches for forming a matching or alignment between the vertices of two graphs. We study a mathematical programming framework for network alignment problem and a sparse variation of it where only a small number of matches between the vertices of the two graphs are possible. We propose a new message passing algorithm that allows us to compute, very efficiently, approximate solutions to the sparse network alignment problems with graph sizes as large as hundreds of thousands of vertices. We also provide extensive simulations comparing our algorithms with two of the best solvers for network alignment problems on two synthetic matching problems, two bioinformatics problems, and three large ontology alignment problems including a multilingual problem with a known labeled alignment.
Towards Practical Oblivious RAM (2011)

We take an important step forward in making Oblivious RAM (O-RAM) practical. We propose an O-RAM construction achieving an amortized overhead of 20X-35X (for an O-RAM roughly 1 terabyte in size), about 63 times faster than the best existing scheme. On the theoretic front, we propose a fundamentally novel technique for constructing Oblivious RAMs: specifically, we partition a bigger O-RAM into smaller O-RAMs, and employ a background eviction technique to obliviously evict blocks from the client-side cache into a randomly assigned server-side partition. This novel technique is the key to achieving the gains in practical performance.
Holistic engineering of Cal-A lipase chain-length selectivity identifies triglyceride binding hot-spot (2019)

Through the application of a region-focused saturation mutagenesis and randomization approach, protein engineering of the Cal-A enzyme was undertaken with the goal of conferring new triglyceride selectivity. Little is known about the mode of triglyceride binding to Cal-A. Engineering Cal-A thus requires a systemic approach. Targeted and randomized Cal-A libraries were created, recombined using the Golden Gate approach and screened to detect variants able to discriminate between long-chain (olive oil) and short-chain (tributyrin) triglyceride substrates using a high-throughput in vivo method to visualize hydrolytic activity. Discriminative variants were analyzed using an in-house script to identify predominant substitutions. This approach allowed identification of variants that exhibit strong discrimination for the hydrolysis of short-chain triglycerides and others that discriminate towards hydrolysis of long-chain triglycerides. A clear pattern emerged from the discriminative variants, identifying the 217-245 helix-loop-helix motif as being a hot-spot for triglyceride recognition. This was the consequence of introducing the entire mutational load in selected regions, without putting a strain on distal parts of the protein. Our results improve our understanding of the Cal-A lipase mode of action and selectivity. This holistic perspective to protein engineering, where parts of the gene are individually mutated and the impact evaluated in the context of the whole protein, can be applied to any protein scaffold.
Micro-Concentrators for a Microsystems-Enabled Photovoltaic System. (2016)

Abstract not provided.
Potentiometric stripping with matrix exchange techniques in flow injection analysis of heavy metals in groundwaters (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotentiometric stripping with matrix exchange techniques in flow injection analysis of heavy metals in groundwatersAlex. Hu, Raymond E. Dessy, and Anders. GraneliCite this: Anal. Chem. 1983, 55, 2, 320–328Publication Date (Print):February 1, 1983Publication History Published online1 May 2002Published inissue 1 February 1983https://pubs.acs.org/doi/10.1021/ac00253a031https://doi.org/10.1021/ac00253a031research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Posterior fusion of the subaxial cervical spine: indications and techniques (2001)

The biomechanical stability of the subaxial cervical spine (C3-7) can be compromised by numerous pathological processes, and the restoration of stability may ultimately require fusion and placement of rigid internal fixation devices. A posterior fusion and stabilization procedure is often used to treat cervical instability secondary to traumatic injury, rheumatoid arthritis, ankylosing spondylitis, neoplastic disease, infections, and previous laminectomy. Numerous techniques and advances in spinal instrumentation have evolved over the last 30 years. The authors review the indications and the various methods for stabilizing and fusing the subaxial cervical spine via posterior approaches.
New mining technology for roof reinforced by grid arranging bolt of complicated seam in work face without worker (2004)

In China, there are a lot of seams which are great in dip angle, variation of thickness and hardness of roof. For instance, Beijing western coalfield, Xinwen coalfield and Zaozhuang coalfield in Shandong province etc. are all the difficult seams. As we know, how to extract the complicated bed seam is a difficult problem. In this paper, the composite reinforcing mechanism of bolt and rock is discussed, a grid shape or ortho-net shape layout of gates, connections and cuts is put forward. In connections and gates, explosion by deep hole of seam is used to fragmentate the coal seam. It makes possible pull out the coal fragments to the conveyer belt by mechanical scraper, and realize the workface without worker. The new mining technique is safe because of no worker is needed in work face. It is available for the similar seam condition of thickness of 1.5 m–6m and dip angle of 0°–40°. contribution for mining technology.
Greedy growing of tree-structured classification rules using a composite splitting criterion (2002)

We establish the Bayes risk consistency of an unsupervised greedy-growing algorithm that produces tree-structured classifiers from labeled training vectors. The algorithm employs a composite splitting criterion equal to a weighted sum of Bayes risk and Euclidean distortion.
A combination of Populus tremula, Solidago virgaurea and Fraxinus excelsior as an anti-inflammatory and antirheumatic drug. A short review. (1995)

Anti-inflammatory properties of Populus tremula are mainly deduced from its components, the well investigated salicylates. Solidago extracts have spasmolytic, antihypertensive and diuretic effects. Fraxinus excelsior itself has hardly been investigated, but its coumarin components proved to have a variety of pharmacological properties, i.e. inhibition of T-cell activation and of the arachidonic acid cascade. Phytodolor N (abbreviated as PD) is a combination of the above mentioned plants. Various in vitro and especially in vivo studies proved its anti-inflammatory and antirheumatic properties, often comparable to non-steroidal anti-inflammatories, but with little or no side effects.
Risk assessment of multi-timescale cascading outages based on Markovian Tree search (2017)

In the risk assessment of cascading outages, the rationality of simulation and efficiency of computation are both of great significance. To overcome the drawback of sampling-based methods that huge computation resources are required and the shortcoming of initial contingency selection practices that the dependencies in sequences of outages are omitted, this paper proposes a novel risk assessment approach by searching on Markovian Tree. The Markovian tree model is reformulated from the quasi-dynamic multi-timescale simulation model proposed recently to ensure reasonable modeling and simulation of cascading outages. Then a tree search scheme is established to avoid duplicated simulations on same cascade paths, significantly saving computation time. To accelerate the convergence of risk assessment, a risk estimation index is proposed to guide the search for states with major contributions to the risk, and the risk assessment is realized based on the risk estimation index with a forward tree search and backward update algorithm. The effectiveness of the proposed method is illustrated on a 4-node power system, and its convergence profile as well as efficiency is demonstrated on the RTS-96 test system.
Producing fluid flow using 3D carbon electrodes (2008)

Moving and manipulating bio-particles and fluids on the microscale is central to many lab-on-a-chip applications. Techniques for pumping fluids which use electric fields have shown promise using both DC and AC voltages. AC techniques, however, require the use of integrated metal electrodes which have a low resistance but can suffer from unwanted chemical reactions even at low potentials. In this paper we introduce the use of carbon MEMS technology (C-MEMS), a fabrication method which produces 3D conductive polymeric structures. Results are presented of the fabrication of an innovative design of 3D AC-electroosmotic micropump and preliminary experimental measurements which demonstrate the potential of both the technology and the design.
Oocyte-Follicle Cell Gap Junctions in Xenopus laevis and the Effects of Gonadotropin on Their Permeability (1979)

Junctions between Xenopus laevis oocytes and follicle cells have been identified as gap junctions by the passage of microinjected fluorescent dye from oocytes to follicle cells. The opening or assembly of these junctions, or both, appears to be regulated by gonadotropins.
Constructing trees in parallel (1989)

An O(log ~ n) time, n2/logn processor as well as an O(log n) time, n3/log n processor CREW deterministic parallel algorithms are presented for constructing Huffman codes from a given list of frequences. The time can be reduced to O(log n(loglog n) 2) on an CRCW model, using only n2/(log log n) 2 processors. Also presented is an optimal O(log n) time, O(n/log n) processor EREW parallel algorithm for constructing a tree given a list of leaf depths when the depths are monotonic. An O(log 2 n) time, n processor parallel algorithm is given for the general tree construction problem. We also give an O(log 2 n) time n2/log2n processor algorithm which finds a nearly optimal binary search tree. An O(log 2 n) time n 2'36 processor algorithm for recognizing linear context free languages is given. A crucial ingredient in achieving those bounds is a formulation of these problems as multiplications of special matrices which we call concave matrices. The structure of these matrices makes their parallel multiplication dramatically more efficient than that of arbitrary matrices.
Interleukin 1 derived from human endothelial cells enhances the binding and chemotactic step of T lymphocyte emigration. (1988)

Recent evidence indicates that interleukin 1 (IL-1) from different sources has varying molecular weights, amino acid and gene sequences and biological properties. In previous experiments, it has been shown that monocyte derived IL-1 was chemotactic for lymphocytes and stimulated their binding to endothelial cells (EC). These phenomena are important in the emigration of lymphocytes in inflammatory states. In the present investigation, EC were stimulated with LPS and from the supernatants the IL-1 activity was isolated. After AcA 54 gel filtration, the active 17 kD fraction was further purified by chromatofocusing, yielding active fractions with pI of 7.0 and 5.0. All of these fractions showed T lymphocyte chemotactic activity, stimulated the binding of T cells to EC and the proliferation of fibroblasts. It is concluded, therefore, that EC-derived IL-1 has similar biological activity to that of monocyte-derived IL-1 and that it can exert a true autocrine effect at the blood-tissue endothelial interface.
The use of spontaneous Raman scattering for hydrogen leak detection (1994)

A fiber optic probe has been built and demonstrated that utilizes back scattered spontaneous Raman spectroscopy to detect and identify gaseous species. The small probe, coupled to the laser and data acquisition equipment with optical fibers, has applications in gaseous leak detection and process monitoring. The probe design and data acquisition system are described. Raman scattering theory has been reviewed and the results of intensity calculations of hydrogen and nitrogen Raman scattering are given. Because the device is in its developmental stage, only preliminary experimental results are presented here. Intensity scans across the rotational-vibrational Raman lines of nitrogen and hydrogen are presented. Nitrogen at a partial pressure of 0.077 MPa was detected. Hydrogen at a partial pressure of 2 kPa approached the lower limit of detectability with the present apparatus. Potential instrument improvements that would allow more sensitive and rapid hydrogen detection are identified.
A new cell search scheme in 3GPP long term evolution downlink, OFDMA systems (2009)

This paper presents a cell search procedure in 3rd Generation Partnership Project (3GPP) Long Term Evolution (LTE) downlink systems. The proposed cell search procedure contains three steps. In the beginning, conventional mode detection, symbol timing detection and fractional carrier frequency offset (CFO) estimation methods are adopted so that frequency-domain signal processing can be performed subsequently. Secondly, a new joint detection method for integer carrier frequency offset and sector cell index information is proposed, which is shown to be capable of resisting symbol timing error. Finally, we also proposed a detection method for frame timing and cell identity (ID) group information without explicit channel estimates. Simulation results demonstrate that the proposed scheme with lower detection error probability is effective and robust compared with some conventional approaches.
Interplay Between Malware Epidemics and Honeynet Potency in Industrial Control System Network (2020)

The Industrial Control System (ICS) is widely used in industrial processes, such as power grids, water conservancy, natural gas, petrochemical and so on. More and more cyber attacks are targeting the ICS worldwide. This paper presents a novel honeynet-based epidemic model in ICS network. The honeynet is an active approach that can attract malware attacks and provide sample information and immunization strategy of the malware. An epidemic model with immunization and quarantine in ICS network is formulated to explore the dynamics of the malware propagation, and the honeynet potency is analyzed as well. Theoretical analysis reveals the disease-free and endemic equilibrium of our model, then the local and global stability of the disease-free (endemic) equilibrium are examined by the basic reproduction number. Furthermore, numerical experiments show that the honeypot with more system vulnerabilities is conducive to suppress the malware epidemic, and the honeynet with lower average degree power low index can be more effectively. In addition, simulation experiments provide the actual behavior of malware propagation in the ICS network and verification of our derivations.
Natural and artificial (2007)

This month, Paula Hammond's activities focus on light and dark and grouping and changing materials. She explains the key concepts with some practical activities
Originalarbeiten: Human Serum Albumin Microspheres for Lung Imaging – Preparation and Evaluation (1978)

Preparation of human serum albumin microspheres of well defined particle size distribution using a spinning disc aerosol generator has been investigated by the authors. A set up is described for bulk preparation of microspheres suitable for lung imaging. A simple procedure for denaturation of the microspheres by direct oven heating has been standardised. Methods for Tc99m labelling of these microspheres with high radiochemical yield and purity have been studied. Uptake and clearance of the labelled microspheres have been followed in experimental animals. Histopathological examination has been carried out to confirm biodegradability and safety of the microspheres. The microspheres have shown excellent lung uptake and have been found to be very safe for administration.