gebhart/patrepeval huggingface dataset:
Fusion of spectral models for dynamic modeling of sEMG and skeletal muscle force (2012)

In this paper, we present a method of combining spectral models using a Kullback Information Criterion (KIC) data fusion algorithm. Surface Electromyographic (sEMG) signals and their corresponding skeletal muscle force signals are acquired from three sensors and pre-processed using a Half-Gaussian filter and a Chebyshev Type- II filter, respectively. Spectral models - Spectral Analysis (SPA), Empirical Transfer Function Estimate (ETFE), Spectral Analysis with Frequency Dependent Resolution (SPFRD) - are extracted from sEMG signals as input and skeletal muscle force as output signal. These signals are then employed in a System Identification (SI) routine to establish the dynamic models relating the input and output. After the individual models are extracted, the models are fused by a probability based KIC fusion algorithm. The results show that the SPFRD spectral models perform better than SPA and ETFE models in modeling the frequency content of the sEMG/skeletal muscle force data.
High-efficiency HIT solar cells with a very thin structure enabling a high Voc (2011)

To increase the competitiveness of HIT (Heterojunction with Intrinsic Thin-layer) solar cells, we have been working on the enhancing their conversion efficiency. This time, we improved the heterojunction of the HIT solar cell, which made it possible to enhance the cell conversion efficiency. In addition, we have developed module technologies such as a new tab design and anti-reflection coated glass. By combining these technologies, we have achieved 240-W model with module conversion efficiency of 19.0%. Those HIT solar cells have the world's highest level of cell conversion efficiency 21.6% at the mass-production stage. We have also been investigating the performance of thinner HIT solar cell using crystalline silicon (c-Si) wafers less than 100 μm in thickness. To minimize optical losses, such as the ultraviolet light absorption in the front transparent conductive oxide (TCO) layer and amorphous Si (a-Si) layers, and the near-infrared light absorption in the rear TCO layer, we have improved the deposition conditions of a-Si, and developed the TCO material respectively. To improve the surface passivation quality of the a-Si/c-Si heterointerface, we have examined our fabrication process from these three viewpoints: (1) the cleanliness of the c-Si surface, (2) the damage in the deposition process, and (3) the quality of the deposited a-Si layer. As a result, we have achieved an excellent Voc of 0.747 V with 58- and 75-μm-thick cells.
Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome (2009)

Down syndrome (DS) is the most prevalent form of intellectual disability caused by the triplication of approximately 230 genes on chromosome 21. Recent data in Ts65Dn mice, the foremost mouse model of DS, strongly suggest that cognitive impairment in individuals with DS is a consequence of reduced synaptic plasticity because of chronic over-inhibition. It remains unclear however whether changes in plasticity are tied to global molecular changes at synapses, or are due to regional changes in the functional properties of synaptic circuits. One interesting framework for evaluating the activity state of the DS brain comes from in vitro studies showing that chronic pharmacological silencing of neuronal excitability orchestrates stereotyped changes in the protein composition of synaptic junctions. In the present study, we use proteomic strategies to evaluate whether synapses from the Ts65Dn cerebrum carry signatures characteristic of inactive cortical neurons. Our data reveal that synaptic junctions do not exhibit overt alterations in protein composition. Only modest changes in the levels of synaptic proteins and in their phosphorylation are observed. This suggests that subtle changes in the functional properties of specific synaptic circuits rather than large-scale homeostatic shifts in the expression of synaptic molecules contribute to cognitive impairment in people with DS.
[Prevalence and prognostic significance of major risk factors and some reproductive system changes in the development of atherosclerosis and ischemic heart disease in women of child-bearing age]. (2000)

Between the incidence of AS and IHD and duration of the conditions studied a functional relation exists due to disorders of lipid metabolism and high arterial pressure.
Factor VII Deficiency Impairs Cutaneous Wound Healing in Mice (2010)

Skin keratinocytes express tissue factor (TF) and are highly associated with skin wound healing. Although it has been demonstrated that perivascular TF expression in granulation tissue formed after dermal injury is downregulated during healing, studies of the mechanism of factor (F) VII, a TF ligand, in skin wound healing are lacking. We reported the use of a dermal punch model to demonstrate that low-expressing FVII mice (approximately 1% of wild type [WT]) exhibited impaired skin wound healing compared with WT controls. These low-FVII mice showed defective reepithelialization and reduced inflammatory cell infiltration at wound sites. This attenuated reepithelialization was associated with diminished expression of the transcription factor early growth response 1 (Egr-1). In vitro, Egr-1 was shown to be essential for the FVIIa-induced regulation of keratinocyte migration and inflammation. Both Egr-1 upregulation and downstream inflammatory cytokine appearance in keratinocytes depended on FVIIa/TF/protease-activated receptor 2 (PAR-2)-induced signaling and did not require subsequent generation of FXa and thrombin. The participation of Egr-1 in FVIIa-mediated regulation of keratinocyte function was confirmed by use of Egr-1-deficient mice, wherein a significant delay in skin wound healing after injury was observed, relative to WT mice. The results from these studies demonstrate an in vivo mechanistic relationship between FVIIa, Egr-1 and the inflammatory response in keratinocyte function during the wound healing process.
Integration of organic LEDs and amorphous Si TFTs onto unbreakable metal foil substrates (2002)

A long sought goal has been a flat panel display that is unbreakable, lightweight, flexible, and low-cost. Organic LEDs (OLEDs) have the potential for such a technology because of their demonstrated performance, their lack of a need for a crystalline substrate, and potential low cost (e.g, deposition by spin-coating). Amorphous Si (a-Si) TFTs are in widespread production for the switching and storage elements in active matrix liquid crystal displays (AMLCDs). Both of these technologies, however, are conventionally fabricated on breakable glass substrates. In this paper, we report the integration of amorphous Si TFTs and OLEDs onto thin stainless steel foils, and the demonstration of a simple circuit in which the TFT drives the OLED. The finished substrate (40/spl times/40 mm/sup 2/) has been dropped down 30 feet onto a concrete floor with no degradation in device performance. The work shows that a-Si TFTs can provide adequate current levels to drive OLEDs.
Prediction of IMD in LDMOS transistor amplifiers using a new large-signal model (2002)

In this paper, the intermodulation distortion (IMD) behavior of LDMOS transistors is treated. First, an analysis is performed to explain measured IMD characteristics in different classes of operation. It is shown that the turn-on region plays an important role in explaining measured IMD behavior, which may also give a clue to the excellent linearity of LDMOS transistors. Thereafter, with this knowledge, a new empirical large-signal model with improved capability of predicting IMD in LDMOS amplifiers is presented. The model is verified against various measurements at low as well as high frequency in a class-AB power amplifier circuit.
Inhibition of Adhesion of Plasmodium falciparum -Infected Erythrocytes by Structurally Defined Hyaluronic Acid Dodecasaccharides (2001)

We recently reported that Plasmodium falciparum-infected erythrocytes (IRBCs) can adhere to hyaluronic acid (HA), which appears to be a receptor, in addition to chondroitin sulfate A (CSA), for parasite sequestration in the placenta. Further investigations of the nature and specificity of this interaction indicate that HA oligosaccharide fragments competitively inhibit parasite adhesion to immobilized purified HA in a size-dependent manner, with dodecasaccharides being the minimum size for maximum inhibition. Rigorously purified and structurally defined HA dodecasaccharides, free of contamination by CSA or other glycosaminoglycans, effectively inhibited IRBC adhesion to HA but not CSA, providing compelling evidence of a specific interaction between IRBCs and HA.
Pathofysiologie van nachtelijke polyurie: circadiaanse ritmes in waterhuishouding (2014)

Nachtelijke polyurie ligt aan de basis van verschillende urologische symptomen.Daarnaast is het ook geassocieerd met systemische aandoeningen (hartfalen, nierfalen, het slaapapneusyndroom, hypertensie) die mogelijks een gelijkaardig ontstaansmechanisme vertonen.Onderzoek naar stoornissen in glomerulaire filtratie, waterdiurese en osmotische diurese is noodzakelijk om het ontstaansmechanisme van nachtelijke polyurie in de toekomst te ontrafelen. Klinisch belangPersonen die 's nachts opstaan om te plassen, vertonen een gefragmenteerde slaap, wat geassocieerd is met een verminderde levenskwaliteit en een verhoogde morbiditeit en mortaliteit.Tot 75% van deze patinten met nycturie hebben een verhoogde nachtelijke urineproductie (1).Ook andere urologische symptomen, zoals urinaire incontinentie en retentie worden geassocieerd met nachtelijke polyurie (2, 3).Bij patinten met een ruggenmergletsel en een neurogene blaas kan deze verhoogde nachtelijke urineproductie resulteren in belangrijke complicaties.De nachtelijke dilatatie van de blaas kan aanleiding geven tot urineweginfecties, hydronefrose, urinaire incontinentie, autonome hyperreflexie Om deze complicaties te vermijden kan het aangewezen zijn om de blaas 's nachts extra te ledigen, meestal door middel van (zelf)sondage, wat bijgevolg weer leidt tot slaapfragmentatie (4-6). Diagnose nachtelijke polyurieNachtelijke polyurie wordt gedefinieerd als een nachtelijke urineproductie groter dan 20-30% van de totale 24u-urineproductie (7).Opdat deze 24u-urineproductie ongewijzigd zou blijven, wordt de verhoogde nachtelijke urineproductie gecompenseerd door een lagere urineproductie overdag (8).Nadat een plaskalender de aanwezigheid van nachtelijke polyurie aantoont, wordt er in de klinische praktijk een diuretische of anti-diuretische behandeling opgestart (1, 9).Dit gebeurt tot op heden zonder de onderliggende oorzaak van de verhoogde urineproductie te kennen.Om in de toekomst de onderliggende oorzaak van nachtelijke polyurie te kunnen aanpakken, is het essentieel om voor elke patint te determineren wat het onderliggend pathofysiologisch mechanisme is van zijn/haar nachtelijke polyurie.
Energy distribution properties of focused ion beams from liquid metal ion sources (1995)

Summary form only given, as follows. The field-emitted electron and ion beams in a high-voltage diode are found to be sources of very high brightness. For example, liquid metal ion sources (LMIS) produce ion beams of 5 /spl mu/A current from a source size estimated to 10/sup -7/ cm. This is why the focused ion beams are often used in the direct doping of semiconductors, in lithography, in semiconductor mask repair, and in micromachining. The width of energy distribution in high-brightness beams is often several tens of electron volts, even if thermal agitation at the emitter is a fraction of an electron volt. Typical diode voltage of the field emission source is 10 kV, which is much larger than several tens of electron volts. The energy distribution may not look important. However, a 10-eV energy spread causes a tremendous problem if the ion beams mentioned above must be focused to a spot the size of a fraction of a micron (/spl mu/m) to be useful in semiconductor mask repair. A theoretical model for energy spread and shift of peak energy distribution in a charged particle beam is developed. The beam may expand radially and axially as it propagates downstream. Charged particles placed randomly in the beam possess different potentials, which are converted to different kinetic energies as the beam propagates and expands. This randomness introduces energy spread in the beam. It is also shown that the shift of peak energy distribution in beam particles is proportional to the one-third power of the beam current, which is the manifestation of random particle locations.
[Complex evaluation of the organism's protective systems as the method of prognosis and diagnosis of complicated course of necrotizing pancreatitis]. (2003)

The data, obtained as a result of the protective systems state (immunity, hemostasis, organism natural resistance) investigation in 20 patients with complicated course of necrotic pancreatitis, are adduced. There was determined, that the lowering of the oxygen dependent and oxygen independent functions of neutrophils, the lysosomic cationic proteins content correlates significantly with course of diseases severity. High concentration in the blood serum of anti-inflammatory cytokines (the leucocytes depression phenomenon) in combination with the oxygen dependent and oxygen independent function of phagocytes depression constitutes the criterion of complicated and unfavourable course of necrotic pancreatitis. Theoretical substantiation of the results is presented.
Early Discharge from the Emergency Department Based on Soluble Urokinase Plasminogen Activator Receptor (suPAR) Levels: A TRIAGE III Substudy (2019)

This trial is registered with NCT02643459.
Ovarian artery resistance index as a marker of pituitary suppression (2002)

Dear Sir, We read with great interest the paper by Dada and colleagues (Dada et al., 2001). They conclude that the Doppler resistance indices of the ovarian arteries, and in particular the resistance index (RI), were satisfactory predictors of pituitary suppression during GnRH treatment.
Multivariate rank via entropic optimal transport: sample efficiency and generative modeling (2021)

The framework of optimal transport has been leveraged to extend the notion of rank to the multivariate setting while preserving desirable properties of the resulting goodness-of-fit (GoF) statistics. In particular, the rank energy (RE) and rank maximum mean discrepancy (RMMD) are distribution-free under the null, exhibit high power in statistical testing, and are robust to outliers. In this paper, we point to and alleviate some of the practical shortcomings of these proposed GoF statistics, namely their high computational cost, high statistical sample complexity, and lack of differentiability with respect to the data. We show that all these practically important issues are addressed by considering entropy-regularized optimal transport maps in place of the rank map, which we refer to as the soft rank. We consequently propose two new statistics, the soft rank energy (sRE) and soft rank maximum mean discrepancy (sRMMD), which exhibit several desirable properties. Given $n$ sample data points, we provide non-asymptotic convergence rates for the sample estimate of the entropic transport map to its population version that are essentially of the order $n^{-1/2}$ when the starting measure is subgaussian and the target measure has compact support. This result is novel compared to existing results which achieve a rate of $n^{-1}$ but crucially rely on both measures having compact support. We leverage this result to demonstrate fast convergence of sample sRE and sRMMD to their population version making them useful for high-dimensional GoF testing. Our statistics are differentiable and amenable to popular machine learning frameworks that rely on gradient methods. We leverage these properties towards showcasing the utility of the proposed statistics for generative modeling on two important problems: image generation and generating valid knockoffs for controlled feature selection.
Documentation of Computerized Laboratory Systems: System Definition at the Management Level (1975)

A set of guidelines for documenting computerized laboratory systems at the management level is presented. The guidelines detail the various documentation that may be required by companies which utilize financial factors to determine project feasibility. The guidelines are divided into five arbitrarily defined phases which are: (1) project initiation, (2) project development, (3) feasibility study, (4) preparation of the computer proposal, and (5) project approval. The project initiation phase includes establishing the need for computerization, determining laboratory structure and functions, conducting the laboratory evaluation, developing a proposed scope, and establishing the financial budget. The project development phase includes how to prepare a computerization objective and the assignment of personnel to the project. Included in the feasibility study are preparation of specifications, vendor contact, environmental considerations, determination of project costs, and initiating changes to the budget. Details are also presented for the preparation of the computer proposal and final approval factors.
Room-Temperature Continuous-Wave Two-Chip THz-Emitting Semiconductor Disk Laser (2020)

We demonstrate a room-temperature, continuous-wave, THz-generating laser, which provides 1-THz output, based on intracavity frequency conversion in a periodically-poled lithium niobate crystal using two serially-connected similar vertical-external-cavity surface-emitting laser chips in one cavity for power-scalability.
Latent Adeno-Associated Virus Infection Elicits Humoral but Not Cell-Mediated Immune Responses in a Nonhuman Primate Model (1999)

Latent infection with wild-type (wt) adeno-associated virus (AAV) was studied in rhesus macaques, a species that is a natural host for AAV and that has some homology to humans with respect to the preferred locus for wt AAV integration. Each of eight animals was infected with an inoculum of 10(10) IU of wt AAV, administered by either the intranasal, intramuscular, or intravenous route. Two additional animals were infected intranasally with wt AAV and a helper adenovirus (Ad), while one additional animal was inoculated with saline intranasally as a control. There were no detectable clinical or histopathologic responses to wt AAV administration. Molecular analyses, including Southern blot, PCR, and fluorescence in situ hybridization, were performed 21 days after infection. These studies indicated that AAV DNA sequences persisted at the sites of administration, albeit at low copy number, and in peripheral blood mononuclear cells. Site-specific integration into the AAVS1-like locus was observed in a subset of animals. All animals, except those infected by the intranasal route with wt AAV alone, developed a humoral immune response to wt AAV capsid proteins, as evidenced by a >/=fourfold rise in anti-AAV neutralizing titers. However, only animals infected with both wt AAV and Ad developed cell-mediated immune responses to AAV capsid proteins. These findings provide some insights into the nature of anti-AAV immune responses that may be useful in interpreting results of future AAV-based gene transfer studies.
Sex Disparities in Diagnostic Evaluation and Revascularization in Patients With Acute Myocardial Infarction—A 15‐Year Nationwide Study (2023)

Background Although sex disparities in the diagnostic evaluation and revascularization of patients with acute myocardial infarction are well documented, no study has evaluated longitudinal trends in these disparities. Methods and Results Using the National Inpatient Sample from 2005 to 2019, 9 259 932 patients with acute myocardial infarction were identified. We divided 15 years into five 3-year periods. The primary objective was to evaluate sex-based trends in the use of diagnostic angiography, percutaneous coronary intervention, and coronary artery bypass graft (CABG) among patients with non-ST-segment-elevation myocardial infarction and ST-segment-elevation myocardial infarction (STEMI) over 15 years. The secondary objective was to evaluate sex disparities in mortality, length of stay, and cost. For non-ST-segment-elevation myocardial infarction, we saw a small reduction in sex disparity in the use of all diagnostic angiography in period 5 versus period 1 (4% versus 5.3%; <i>P</i><0.01), no change in sex disparity in percutaneous coronary intervention use in period 5 versus period 1 (5.6% versus 5%; <i>P</i>=0.16), and a widening sex disparity in CABG in period 5 versus period 1 (5.4% versus 4.4%; <i>P</i><0.01). However, we noted decreasing sex disparities in the use of diagnostic angiography, percutaneous coronary intervention, and CABG for ST-segment-elevation myocardial infarction in mostly all periods compared with period 1 (<i>P</i><0.05, all comparisons), but differences still existed in period 5. Risk-adjusted in-hospital mortality was higher after CABG for non-ST-segment-elevation myocardial infarction and after percutaneous coronary intervention and CABG for ST-segment-elevation myocardial infarction in women than men. Conclusions Despite variable trends in sex disparities in diagnostic and revascularization procedures for acute myocardial infarction, disparities still exist.
In-situ doping influence on Vapor Liquid Solid Silicon nanowires electrical pRoperties for gas sensing application (2013)

International audience
Electrospray ionization mass spectrometry: Deconvolution by an Entropy-Based algorithm (1992)

ADVERTISEMENT RETURN TO ISSUEPREVResearch ArticleNEXTElectrospray ionization mass spectrometry: Deconvolution by an Entropy-Based algorithmBruce B. ReinholdBruce B. ReinholdHarvard University School of Public Health, 665 Huntington Avenue, 02115, Boston, MAMore by Bruce B. Reinhold and Vernon N. ReinholdVernon N. ReinholdHarvard University School of Public Health, 665 Huntington Avenue, 02115, Boston, MAMore by Vernon N. ReinholdCite this: J Am Soc Mass Spectrom 1992, 3, 3, 207–215Publication Date (Print):March 1, 1992Publication History Received12 March 1991Accepted21 August 1991Revised21 August 1991Published online1 March 1992Published inissue 1 March 1992https://pubs.acs.org/doi/10.1016/1044-0305(92)87004-Ihttps://doi.org/10.1016/1044-0305(92)87004-Iresearch-articleACS PublicationsRequest reuse permissionsArticle Views98Altmetric-Citations90LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Method and apparatus for routing data in an inter-nodal communications lattice of a massively parallel computer system by employing bandwidth shells at areas of overutilization (2023)

A massively parallel computer system contains an inter-nodal communications network of node-to-node links. An automated routing strategy routes packets through one or more intermediate nodes of the network to reach a final destination. The default routing strategy is altered responsive to detection of overutilization of a particular path of one or more links, and at least some traffic is re-routed by distributing the traffic among multiple paths (which may include the default path). An alternative path may require a greater number of link traversals to reach the destination node.