gebhart/patrepeval huggingface dataset:
The Best of Both Worlds: Combining 3D Deformable Models with Active Shape Models (2007)

Reliable 3D tracking is still a difficult task. Most parametrized 3D deformable models rely on the accurate extraction of image features for updating their parameters, and are prone to failures when the underlying feature distribution assumptions are invalid. Active Shape Models (ASMs), on the other hand, are based on learning, and thus require fewer reliable local image features than parametrized 3D models, but fail easily when they encounter a situation for which they were not trained. In this paper, we develop an integrated framework that combines the strengths of both 3D deformable models and ASMs. The 3D model governs the overall shape, orientation and location, and provides the basis for statistical inference on both the image features and the parameters. The ASMs, in contrast, provide the majority of reliable 2D image features over time, and aid in recovering from drift and total occlusions. The framework dynamically selects among different ASMs to compensate for large viewpoint changes due to head rotations. This integration allows the robust tracking effaces and the estimation of both their rigid and non- rigid motions. We demonstrate the strength of the framework in experiments that include automated 3D model fitting and facial expression tracking for a variety of applications, including sign language.
Chemotherapy-induced apoptosis in melanoma cells is p53 dependent (1998)

Metastatic melanomas are often resistant to chemotherapy. To study whether the p53 mutational status affects chemosensitivity, we compared the responses to chemotherapy of four melanoma cell lines containing the wild-type p53 and four cell lines carrying the mutant p53. Cisplatin, at 10 microM, virtually killed all the cells in the wild-type p53 cell lines, while 57-95% of the cells in the mutant p53 cell lines survived (P = 0.005). After treatment with 100 nM of vincristine, on average 18% of the wild-type p53 melanoma cells survived compared with 55% of the mutant p53 cells (P = 0.04). After treatment with 40 nM, 200 nM or 1 microM of camptothecin the survival rates were, on average, 16%, 8% and 4% for the wild-type p53 melanoma cells, compared with 89%, 67% and 38% for the mutant p53 cells, respectively (P = 0.00004, P = 0.003 and P = 0.04, respectively). The anticancer agents were not toxic to normal melanocytes at doses inducing cytotoxicity in wild-type p53 melanoma cells. The main mechanism of cytotoxicity appears to be drug-induced apoptosis. Cisplatin, camptothecin and vincristine all induced apoptosis in wild-type p53 melanoma cells, but not in mutant p53 cells. Our results suggest that chemotherapy-induced apoptosis in melanoma cells is p53 dependent, and mutation of the p53 gene is an indicator of drug resistance in melanoma.
Chip multiprocessor based on data-driven multithreading model (2007)

Although the dataflow model of execution, with its obvious benefits, has been proposed for a long time, it has not yet been successfully exploited. Nevertheless, as traditional systems have recently started to reach their limits in delivering higher performance, new models of execution that use dataflow-like concepts are being studied. Among these, Data-Driven Multithreading (DDM) is a multithreading model that effectively hides the communication delay and synchronisation overheads. In DDM threads are scheduled as soon as their input data has been produced, that is, in a dataflow-like way. In addition to presenting a motivation to the dataflow model of execution, this paper also presents an overview of the DDM project. In particular, it focuses on the Chip Multiprocessor (CMP) implementation using the DDM model, its hardware, run-time system and performance evaluation. The DDM-CMP inherits the benefits of both the DDM model which allows to overcome the memory wall limitation and the CMP which offers a simpler design, higher degree of parallelism and larger power-performance efficiency, therefore overcoming the power wall. Preliminary experimental results show a significant benefit in terms of both speedup and power consumption, making the DDM-CMP architecture an attractive architecture for future processors.
Relaxation nucléaire de 3He dans un champ magnétique inhomogène (1982)

This article gives a theoretical study of the effects of weak magnetic field gradients on the spin relaxation of a dilute atomic gas. The theory is valid for low or moderate values of the field (the relevant correlation time of the gas is then the diffusion time across the container) as well as for high fields (the intercollision time then plays the most important role). Quantum effects due to particle indistinguishability are included. No consequences of the divergence of the atomic mean free path in a polarized gas at zero temperature are found, in contrast to the situation for viscosity and heat conductivity. On the other hand, substantial effects due to « identical spin rotation effects » are predicted.
Parallel reactions in open chip-based nanovials with continuous compensation for solvent evaporation (2000)

In an earlier report (Litborn, E., Emmer, A., Roeraade, J., Anal. Chim. Acta 1999, 401, 11-19, we described a technique for performing chemistry in chip-based vials. A major problem, solvent evaporation, was partially remedied by using a closed humidity chamber. In this paper we report an improved technique for performing parallel reactions in open, 15 nL volume, chip-based vials. The evaporation of solvent from the reaction fluid was continuously compensated by addition of solvent via an array of microcapillaries. The suitability of the method was demonstrated by performing eight separate peptide maps of myoglobin in parallel, using the three enzymes trypsin, alpha-chymotrypsin and endoproteinase Glu-C. The total amount of myoglobin utilized to perform the eight digests was less than 100 pmol. The corresponding amount of enzymes was ca. 0.1 pmol per reaction. In order to evaluate the operating limits of the technique, a study of the evaporation of solvents from a series of vials with proportionally smaller volumes operated at different temperatures was performed. The results showed that the concept for continuous compensation of solvent evaporation should be applicable to reaction volumes down to 30 pL.
LT-IIc, A Bacterial Type II Heat-Labile Enterotoxin, Induces Specific Lethality in Triple Negative Breast Cancer Cells by Modulation of Autophagy and Induction of Apoptosis and Necroptosis (2018)

Triple negative breast cancer (TNBC) remains a serious health problem with poor prognosis and limited therapeutic options. To discover novel approaches to treat TNBC, we screened cholera toxin (CT) and the members of the bacterial type II heat-labile enterotoxin family (LT-IIa, LT-IIb, and LT-IIc) for cytotoxicity in TNBC cells. Only LT-IIc significantly reduced viability of the TNBC cell lines BT549 and MDA-MB-231 (IC<sub>50</sub> = 82.32 nM). LT-IIc had no significant cytotoxic effect on MCF10A (IC<sub>50</sub> = 2600 nM), a non-tumorigenic breast epithelial cell line, and minimal effects on MCF7 and T47D, ER⁺ cells, or SKBR-3 cells, HER2⁺ cells. LT-IIc stimulated autophagy through inhibition of the mTOR pathway, while simultaneously inhibiting autophagic progression, as seen by accumulation of LC3B-II and p62. Morphologically, LT-IIc induced the formation of enlarged LAMP2+ autolysosomes, which was blocked by co-treatment with bafilomycin A1. LT-IIc induced apoptosis as demonstrated by the increase in caspase 3/7 activity and Annexin V staining. Co-treatment with necrostatin-1, however, demonstrated that the lethal response of LT-IIc is elicited, in part, by concomitant induction of necroptosis. Knockdown of ATG-5 failed to rescue LT-IIc-induced cytotoxicity, suggesting LT-IIc can exert its cytotoxic effects downstream or independently of autophagophore initiation. Collectively, these experiments demonstrate that LT-IIc acts bifunctionally, inducing autophagy, while simultaneously blocking autolysosomal progression in TNBC cells, inducing a specific cytotoxicity in this breast cancer subtype.
Non-viraemic transmission of Thogoto virus: influence of time and distance (1989)

Previous studies have demonstrated that Thogoto virus is transmitted from infected to uninfected ticks when co-feeding on uninfected guinea-pigs, even though the guinea-pigs do not develop detectable viraemia. The dynamics of this 'non-viraemic transmission' were investigated. The percentage of nymphs (recipients) that acquired virus increased from zero, when co-feeding with infected adults (donors) for 3 d, to 80% for a co-feeding period of 5 d. No statistically significant difference was detected when infected donors and uninfected recipients were separated physically up to a maximum distance of approximately 160 mm. These results indicate that the temporal, but not the spatial, relationship affects the number of recipient ticks that become infected.
Socioeconomic status and the effect of information-based versus structural nutrition interventions on food choice: randomized experiments in a virtual fast food restaurant (2019)

Socioeconomic status and the effect of information-based versus structural nutrition interventions on food choice: a randomized experiment in a virtual fast food restaurant
A GIS-based analysis and prediction of parcel land-use change in a coastal tourism destination area, 1999 (1999)

As an integrated part of the NASA/SC-EPSCoR Wetland Research Project involving three institutions&#13;\nin South Carolina, this study focuses on the land-use change and its impacts. The overall&#13;\npurpose is to better understand the process of coastal land-use change and its consequences in order&#13;\nto minimize negative impacts and to sustain coastal resources and development around nearby&#13;\nwetlands. For the Murrells Inlet component of the project, four immediate objectives were: Seek an alternative approach that emphasizes human aspects of issues related to land-use change; Develop a parcel based GIS model for assessing land-use change in the past; Apply this model to observe and map tenure change, residential change and commercial change&#13;\nfor the Murrells Inlet area; and Build and apply a logistic regression model to predict the possibilities of future land-use change&#13;\nfor the area.
Wasiat Wajibah Terhadap Anak Angkat Dalam Kompilasi Hukum Islam (2015)

Hukum Islam membolehkan mengangkat anak namun dalam batas-batas tertentu iaitu selama tidak membawa akibat Hukum dalam hal hubungan darah, hubungan pewalian dan hubungan pewarisan dari orang tua angkat. Ia tetap menjadi ahli waris dari orang tua kandungnya dan anak tersebut tetap memakai nama dari ayah kandungnya. Di Indonesia, perundangan wasiat ini diatur dalam Kompilasi Hukum Islam. Fasal 209 Kompilasi Hukum Islam memperuntukan bahawa terhadap anak angkat yang tidak menerima wasiat diberi wasiat wajibah sebanyak-banyaknya 1/3 dari harta warisan orang tua angkatnya. Justeru, objektif kajian ini adalah untuk mengkaji fasal 209 untuk membandingkan antara Kompilasi Hukum Islam dengan Hukum Islam berdasarkan pandangan fuqaha dan hujah-hujah mereka. Kajian ini mengunakan kaedah analisis kandungan. Data-data dikumpul mengunakan kaedah analisis dokumen primer, sekunder dan perbandingan . Hasil kajian mendapati bahawa Hukum Islam memperbolehkan mengangkat anak namun dalam batas-batas tertentu iaitu selama tidak membawa akibat Hukum dalam hal hubungan darah, hubungan pewalian dan hubungan pewarisan dari orang tua angkat. ia tetap menjadi ahli waris dari orang tua kandungnya dan anak tersebut tetap memakai nama dari ayah kandungnya. Sedangkan Kompilasi Hukum Islam menegaskan bahawa anak angkat atau orang tua angkat tidak ada hubungan pewarisan. tetapi sebagai pengakuan mengenai baiknya lembaga pengangkatan anak ( Jabatan Kebajikan Masyarakat) , hubungan antara anak angkat dengan orang tua angkatnya dikukuhkan dengan perantara wasiat atau wasiat wajibah. Kesan kajian ini ialah agar hakim pengadilan agama berani untuk menerapkan Hukum yang jelas kepada masyarakat sesuai fasal 5 ayat 1 undang-undang Nombor 48 Tahun 2008 tentang materi-materi kekuasaan kehakiman yang berbunyi: Hakim dan hakim konstitusi wajib mengali, mengikuti, dan memahami nilai-nilai Hukum rasa keadilan yang jelas dalam masyarakat.
Photorefractive Polymer with Side-Chain Second-Order Nonlinear Optical and Charge-Transporting Groups (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotorefractive Polymer with Side-Chain Second-Order Nonlinear Optical and Charge-Transporting GroupsChanfeng Zhao, Chi-Kyun Park, Paras N. Prasad, Yue Zhang, Saswati Ghosal, and Ryszard BurzynskiCite this: Chem. Mater. 1995, 7, 6, 1237–1242Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/cm00054a026https://doi.org/10.1021/cm00054a026research-articleACS PublicationsRequest reuse permissionsArticle Views382Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A 400-MILLION-YEAR RECORD OF ATMOSPHERIC CARBON DIOXIDE DEDUCED FROM PEDOGENIC CARBONATES (1999)

Calcium carbonate commonly accumulates in soils where mean annual precipitation is <100 cm, a condition met by a large fraction of the Earth's terrestrial surface. Pedogenic carbonates are a common component of fossil soils (paleosols). The carbon isotope composition of pedogenic carbonates meeting specific criteria can be related to ecological conditions and the concentration of carbon dioxide in the atmosphere.



We have collected and analyzed pedogenic carbonates from hundreds of paleosols. These data have been combined with a large number of analyses from the literature. The combined data include paleosols from five continents and formed throughout the last 400 million years. Application of Cerling's CO2 paleobarometer to these data has significantly constrained the history of atmospheric CO2 through this time period.



Results indicate that atmospheric pCO2 has significantly fluctuated throughout the Phanerozoic. High concentrations of atmospheric CO2 levels in the Late Silurian and Devonian dropped to low concentrations in the Late Paleozoic. CO2 levels increased dramatically in the Triassic and subsequently dropped throughout the rest of the Mesozoic, reaching levels comparable with the modern condition prior to the Cretaceous–Tertiary boundary. Levels remained relatively low throughout the Cenozoic.
Towards Novel Multifunctional Pillared Nanostructures: Effective Intercalation of Adamantylamine in Graphene Oxide and Smectite Clays (2014)

Multifunctional pillared materials are synthesized by the intercalation of cage‐shaped adamantylamine (ADMA) molecules into the interlayer space of graphite oxide (GO) and aluminosilicate clays. The physicochemical and structural properties of these hybrids, determined by X‐ray diffraction (XRD), Fourier transform infrared (FTIR), Raman and X‐ray photoemission (XPS) spectroscopies and transmission electron microscopy (TEM) show that they can serve as tunable hydrophobic/hydrophilic and stereospecific nanotemplates. Thus, in ADMA‐pillared clay hybrids, the phyllomorphous clay provides a hydrophilic nanoenvironment where the local hydrophobicity is modulated by the presence of ADMA moieties. On the other hand, in the ADMA‐GO hybrid, both the aromatic rings of GO sheets and the ADMA molecules define a hydrophobic nanoenvironment where sp 3 ‐oxo moieties (epoxy, hydroxyl and carboxyl groups), present on GO, modulate hydrophilicity. As test applications, these pillared nanostructures are capable of selective/stereospecific trapping of small chlorophenols or can act as cytotoxic agents.
Biomechanical Evaluation of Different Designs of Glenospheres in the SMR Reverse Shoulder Prosthesis: Micromotion of the Baseplate and Risk of Loosening (2010)

Background Early outcomes of reverse shoulder arthroplasty have been encouraging. Scapular notching remains a major concern. In an attempt to reduce this problem, newer glenospheres are available. This biomechanical study performed in vitro, assessed the micromotions of baseplate in different designs of glenospheres and the relative risk of loosening. Methods A dynamic shear force was applied to each type of glenosphere in various angles of abduction. The micromotion of the glenoid baseplate after 1000 cycles of dynamic loading was measured and compared. Results Eccentric glenospheres were shown to have increased micromotion compared to the concentric designs of the same size. The greatest baseplate micromotion (26.83 μm) was well within the accepted limit for osseous in growth into uncemented prosthesis. Discussion We therefore conclude that the magnitude of the increased micromotion is small and is not expected to adversely affect osseous in growth onto the glenoid baseplate.
In Vivo Verification of Treatment Source Dwell Times in Brachytherapy of Postoperative Endometrial Carcinoma: A Feasibility Study (2022)

(1) Background: In brachytherapy, there are still many manual procedures that can cause adverse events which can be detected with in vivo dosimetry systems. Plastic scintillator dosimeters (PSD) have interesting properties to achieve this objective such as real-time reading, linearity, repeatability, and small size to fit inside brachytherapy catheters. The purpose of this study was to evaluate the performance of a PSD in postoperative endometrial brachytherapy in terms of source dwell time accuracy. (2) Methods: Measurements were carried out in a PMMA phantom to characterise the PSD. Patient measurements in 121 dwell positions were analysed to obtain the differences between planned and measured dwell times. (3) Results: The repeatability test showed a relative standard deviation below 1% for the measured dwell times. The relative standard deviation of the PSD sensitivity with accumulated absorbed dose was lower than 1.2%. The equipment operated linearly in total counts with respect to absorbed dose and also in count rate versus absorbed dose rate. The mean (standard deviation) of the absolute differences between planned and measured dwell times in patient treatments was 0.0 (0.2) seconds. (4) Conclusions: The PSD system is useful as a quality assurance tool for brachytherapy treatments.
cADP-ribose formation by blood platelets is not responsible for intracellular calcium mobilization (1998)

Human platelet CD38 is a multifunctional ectoenzyme catalysing the synthesis and hydrolysis of cADP-ribose (cADPR), a recently identified calcium-mobilizing agent that acts independently of D-myo-inositol 1,4,5-trisphosphate and is known to be expressed by human platelets. The present work shows that ADP-ribosyl cyclase activity is exclusively a membrane activity, of which the major part is located in plasma membranes and a small part in internal membranes. In broken cells, cyclase activity was insensitive to the presence of calcium and was not modulated by agonists such as thrombin or ADP, whereas in intact cells thrombin increased cADPR formation by 30%, an effect due to fusion of granules with the plasma membrane. In order to assess the role of cADPR as a calcium-mobilizing agent, vesicles were prepared from internal membranes and loaded with 45CaCl2. These vesicles were efficiently discharged by IP3 in a dose-dependent manner, but were not responsive to cADPR or ryanodine in the presence or absence of calmodulin. Thus cADPR is unlikely to play a role in intracellular calcium release in human blood platelets.
A Novel Vibrotactile Display to Improve the Performance of Anesthesiologists in a Simulated Critical Incident (2008)

Our study provides evidence that vibrotactile communication can reduce response time to critical incidents.
Mesomorphic state and types of mesophases (2022)

The paper presents basic types of liquid-crystalline phases obtained in different ways and supermolecular arrangement in those phases. Characteristic features of molecular structure of mesogens are discussed, moreover their influence on liquid-crystalline properties are described too. Examples of the effect of intermolecular interactions on the phase situation of a liquid crystal are given. Keywords: liquid crystals, mesophases, polymorphism, mesogens, molecular structure
A Study of the Relationship Between Microstructure and Photophysics in Organic Semiconductor Blends for Solar Cell Applications (2008)

This thesis is a study of material blends involving organic semiconductors and their application to opto-electronic devices, particularly photovoltaic diodes. Its principal aim is to examine the microstructure of the blend, where microstructure is defined as molecular ordering and spatial arrangement on the nanometer to micrometer scale. In general, each chapter of the thesis presents a novel means by which to influence the microstructure of organic semiconductor blends. These techniques are used as a means to understand how the photophysics of optoelectronic devices is influenced by microstructure. We establish some general principles of how microstructure relates to device performance and also find high performance in some entirely novel device structures and architectures. It is hoped that understanding developed here will lead to improvements in the performance of organic photovoltaic devices.
Controllable Spectral Peak Generation with Ultrashort Pulses using LCOS-SLM Spectral Filter (2022)

Arbitrary controlled spectral peak generation was demonstrated using ultrashort pulse fiber laser and spectral filter with LCOS-SLM. The intense, sharp spectral peak with record high contrast up to 143 was successfully obtained.
Large-Scale Expression Measurement by Hybridization Methods: From High-Density Membranes to "DNA Chips" (1998)

The vast amount of sequence information becoming available on genes from man and from other species calls for corresponding increases in the rate of collection for data of a more functional nature. Expression measurements often constitute a first step in this direction, and can be performed on a reasonably large scale using highly parallel hybridization methods. Large sets of targets (clones, inserts, oligonucleotides) are hybridized with labeled complex probes prepared from total cell or organ mRNA; under the proper conditions, signals measure the relative abundance of each sequence species, and can be acquired quantitatively. These techniques are presently available in three formats: high-density membranes to be hybridized with radioactive complex probes, microarrays of DNA spots (a miniaturized version of the former technique) using fluorescent complex probes, and oligonucleotide chips that, although developed originally for mutation detection, can be adapted to perform expression measurements. The miniaturized formats clearly represent the future, since they allow higher sensitivity, assay of large numbers of entities and hopefully provide the opportunity to use small amounts of starting material.