gebhart/patrepeval huggingface dataset:
A CO2 cycle on Ariel? Radiolytic production and migration to low latitude cold traps (2021)

CO2 ice is present on the trailing hemisphere of Ariel but is mostly absent from its leading hemisphere. The leading/trailing hemispherical asymmetry in the distribution of CO2 ice is consistent with radiolytic production of CO2, formed by charged particle bombardment of H2O ice and carbonaceous material in Ariel's regolith. This longitudinal distribution of CO2 on Ariel was previously characterized using 13 near-infrared reflectance spectra collected at 'low' sub-observer latitudes between 30S to 30N. Here, we investigated the distribution of CO2 ice on Ariel using 18 new spectra: two collected over low sub-observer latitudes, five collected at 'mid' sub-observer latitudes (31 - 44N), and eleven collected over 'high' sub-observer latitudes (45 - 51N). Analysis of these data indicates that CO2 ice is primarily concentrated on Ariel's trailing hemisphere. However, CO2 ice band strengths are diminished in the spectra collected over mid and high sub-observer latitudes. This sub-observer latitudinal trend may result from radiolytic production of CO2 molecules at high latitudes and subsequent migration of this constituent to low latitude cold traps. We detected a subtle feature near 2.13 microns in two spectra collected over high sub-observer latitudes, which might result from a 'forbidden' transition mode of CO2 ice that is substantially stronger in well mixed substrates composed of CO2 and H2O ice, consistent with regolith-mixed CO2 ice grains formed by radiolysis. Additionally, we detected a 2.35-micron feature in some low sub-observer latitude spectra, which might result from CO formed as part of a CO2 radiolytic production cycle.
A Comparative Study of Amoxicillin-Clavulanate and Amoxicillin: Treatment of Otitis Media With Effusion (1988)

A double-blind randomized clinical trial was conducted at two sites comparing amoxicillin-clavulanate potassium (Augmentin) and amoxicillin trihydrate for the treatment of otitis media with effusion ("secretory otitis media"). One hundred eight subjects were randomly assigned to receive a ten-day course of either drug regimen. Clinical response was assessed at ten days and four weeks after entry. For those without middle ear effusion at four weeks, recurrence rates were measured at 8, 12, and 16 weeks after entry. At ten days following entry, 29 (51.8%) of 56 subjects in the amoxicillin-clavulanate-treated group were effusion free compared with 16 (32.0%) of 50 subjects in the amoxicillin-treated group (P = .06). At four weeks following entry, 26 (50.0%) of 50 subjects in the amoxicillin-clavulanate-treated group were effusion free compared with 23 (51.1%) of 45 subjects in the group given amoxicillin. By the 16-week visit, eight (36.4%) of 22 subjects in the amoxicillin-clavulanate-treated group who were effusion free at four weeks had recurrence of effusion, compared with 12 (63.2%) of 19 subjects in the amoxicillin-treated group. This study suggests that there was a favorable clinical response immediately following treatment in the amoxicillin-clavulanate--treated subjects as compared with those treated with amoxicillin, but this benefit was not sustained at the four-week end point.
Kombinierte CT-Koronarangiographie (cCTA) und TAVI-Planung: CT-FFR bei cCTAs ohne morphologische Anzeichen für obstruktive koronare Herzkrankheit (2022)

Zielsetzung Die koronare Herzkrankheit (KHK) ist eine häufige Komorbidität von Patienten vor TAVI. Es wird empfohlen eine obstruktive KHK vor TAVI auszuschließen. Wenn eine obstruktive KHK mittels CT-Koronarangiographie (cCTA) ausgeschlossen werden kann, kann eine zusätzliche Herzkatheteruntersuchung (HKU) vermieden werden. TAVI-Patienten haben häufig eine hohe Plaquelast und einen hohen Kalzium-Score, was den Ausschluss relevanter Stenosen erschwert und vor allem für weniger erfahrene Radiologen eine Herausforderung darstellt. Es ist beschrieben, dass die aus der CT errechnete fraktionelle Flussreserve (CT-FFR) die Sicherheit des Radiologen in die cCTA erhöhen kann. Ziel ist die Beschreibung des Werts der maschinenlernbasierten (ML)-basierten CT-FFR Patienten vor TAVI ohne morphologische Anzeichen für obstruktiven KHK in der cCTA.
Thermodynamic Behavior of Polyelectrolytes with the Lower Critical Solution Temperature (LCST) Phenomenon (1996)

A series of vinyl polymers with L-valine and L-leucine residues, and related copolymers with N-isopropylacrylamide, were studied in aqueous solution at different temperatures (25, 30 and 35°C) and at two ionic strengths (0.01 M and 0.1 M NaCl). The protonation behavior revealed great differences between the polymers that were attributed to the size of the hydrophobic lateral group. Macromolecular shrinkage, occurring above a critical degree of protonation β, was related to hydrophobic forces outweighing the electrostatic repulsions between COO – groups. Low salt concentrations increased the electrostatic potential while high temperatures increased the hydrophobic interaction at lower β. The release of fewer water molecules structured around the polymer chain, responsible for the lower critical solution temperature phenomenon, revealed lower entropy changes at higher temperatures. The reversible configuration of graft polymer chains instantly responded to changes in pH and temperature, modifying the water filtration rates through the pores of cellulose membranes.
Shape memory nanocomposite of poly(L-lactic acid)/graphene nanoplatelets triggered by infrared light and thermal heating (2016)

In this study, the effect of graphene nanoplatelets (GNPs) on the shape memory properties of poly(L-lactic acid) (PLLA) was studied. In addition to thermal activation, the possibility of infrared actuating of thermo-responsive shape memory PLLA/GNPs nanocomposite was investigated. The incorporated GNPs were expected to absorb infrared wave's energy and activate shape memory PLLA/GNPs. Different techniques such as differential scanning calorimetry (DSC), wide-angle X-ray diffraction (WAXD), field emission gun scanning electron microscope (FEG-SEM) and dynamic mechanical thermal analysis (DMTA) were used to characterize samples. DSC and WAXD results indicated that GNPs augmented crystallinity due to nucleating effect of graphene particles. GNPs improved both thermal and infrared activating shape memory properties along with faster response. Pure shape memory PLLA was slightly responsive to infrared light and its infrared actuated shape recovery ratio was 86% which increased to more than 95% with loading of GNPs. Drastic improvement in the crystallinity was obtained in nanocomposites with lower GNPs contents (0.5 and 1 wt%) due to finer dispersion of graphene which resulted in more prominent mechanical and shape memory properties enhancement. Infrared activated shape memory PLLA/GNPs nanocomposites can be developed for wireless remote shape control of smart medical and bio-systems.
Parkinson’s Disease: Neurotransmitter and Neurotoxin Receptors and Their Genes (1990)

Studies of the changes in brain neurotransmitter and neurotoxin receptors in Parkinson's disease now provide information about the state of many receptors. The status of dopamine receptors in the striatum, the possibility that specific neurotoxin receptors exist and the likelihood that receptors in other brain regions, including pathologically involved substantia nigra and cerebral cortex, can provide meaningful information about brain function and the disease are reviewed. Increasing information about these receptors is also available from molecular biological studies of dopamine receptors, and of genes encoding several of the putative candidate sites for possible neurotoxin action. Such approaches are providing an increasingly important perspective on Parkinson's disease therapeutics and possible pathogenesis.
Rydberg-Atom Quantum Simulation and Chern Number Characterization of a Topological Mott Insulator (2012)

In this work we consider a system of spinless fermions with nearest and next-to-nearest neighbor repulsive Hubbard interactions on a honeycomb lattice, and propose and analyze a realistic scheme for analog quantum simulation of this model with cold atoms in a two-dimensional hexagonal optical lattice. To this end, we first derive the zero-temperature phase diagram of the interacting model within a mean-field theory treatment. We show that besides a semi-metallic and a charge-density-wave ordered phase, the system exhibits a quantum anomalous Hall phase, which is generated dynamically, i.e. purely as a result of the repulsive fermionic interactions and in the absence of any external gauge fields. We establish the topological nature of this dynamically created Mott insulating phase by the numerical calculation of a Chern number. Based on the knowledge of the mean-field phase diagram, we then discuss in detail how the interacting Hamiltonian can be engineered effectively by state-of-the-art experimental techniques for laser-dressing of cold fermionic ground-state atoms with electronically excited Rydberg states that exhibit strong dipolar interactions.
Validation of Proposed Photovoltaic Energy Rating Standard and Sensitivity to Environmental Parameters (2008)

PV devices are currently compared on the basis of the power measurements, which might not be as meaningful as a comparator as the energy yield. The energy rating standard proposed by the IEC promises to overcome this shortcoming. It has been implemented in three institutes and the issues with the current drafts are evaluated. The data required as the input for the energy rating is normally not available and synthetic datasets will have to be used or parts need to be estimated for validation studies. The validation against outdoor data shows that the uncertainty of the input data, specifically the angular distribution of the diffuse irradiance, makes the energy prediction part virtually not applicable for energy yield calculations. The validation effort shows a reduction of the standard deviation in the measurements, indicating that all environmental effects are considered. The evaluation of the originally proposed standard days shows that there is little information to be gained in their application as they are not representative of realistic conditions; they are enveloping the possible environments. This will in some cases over-emphasise the importance of certain effects, as their contribution to the overall energy yield might be negligible. Overall, the proposed standard represents an important advance on power rating. The standard is able to identify differences in device technologies. Further work might be required to make the output more relevant to a wider variety of users, though.
Conflict-Free Coloring of Intersection Graphs (2018)

A conflict-free[Formula: see text]-coloring of a graph [Formula: see text] assigns one of [Formula: see text] different colors to some of the vertices such that, for every vertex [Formula: see text], there is a color that is assigned to exactly one vertex among [Formula: see text] and [Formula: see text]’s neighbors. Such colorings have applications in wireless networking, robotics, and geometry, and are well studied in graph theory. Here we study the conflict-free coloring of geometric intersection graphs. We demonstrate that the intersection graph of [Formula: see text] geometric objects without fatness properties and size restrictions may have conflict-free chromatic number in [Formula: see text] and in [Formula: see text] for disks or squares of different sizes; it is known for general graphs that the worst case is in [Formula: see text]. For unit-disk intersection graphs, we prove that it is NP-complete to decide the existence of a conflict-free coloring with one color; we also show that six colors always suffice, using an algorithm that colors unit disk graphs of restricted height with two colors. We conjecture that four colors are sufficient, which we prove for unit squares instead of unit disks. For interval graphs, we establish a tight worst-case bound of two.
Archaic Strains of Methicillin-Resistant Staphylococcus aureus: Molecular and Microbiological Properties of Isolates from the 1960s in Denmark (2000)

Methicillin-resistant Staphylococcus aureus (MRSA) isolated in the 1960s in Denmark are among the historically earliest samples of these bacteria. We determined microbiological and molecular properties of 46 such isolates. They showed remarkably uniform properties, which included: (i) low methicillin MIC value (6-25 microg/ml); (ii) heterogeneous expression of resistance; (iii) the presence of a single, common, mecA polymorph II; (iv) lack of the regulatory gene mecI; (v) frequent lack of Tn554; and (vi) a common pulsed-field gel electrophoresis (PFGE) type. These properties, together with the chronological dates of isolation, and recovery of the strains from 18 hospitals scattered over Denmark, suggest that they represent a lineage close in time to the evolutionary origin of European strains of MRSA.
Rhodium‐Catalyzed Direct Amination of Arene C‐H Bonds Using Azides as the Nitrogen Source (2014)

Abstract The article reports the practical procedure of the direct C ‐ H amination and amidation reaction of arenes using aryl sulfonyl azides as the source of the nitrogen functionality, which releases molecular nitrogen as the single by‐product. This reaction is catalyzed under mild conditions by a cationic rhodium complex [Cp*Rh(III)]2+( SbF 6 )2 2‐ (Cp*, ?5‐pentamethylcyclopentadienyl) without requiring external oxidants. This procedure offers a very efficient and practical route to aryl amines and amides.
An improved electronic ballast for the fluorescent lamps (1995)

The ''charge pump" electronic ballast circuit, which employs a charging capacitor and a high frequency ac source to implement the power factor correction (PFC), has become an attractive topology for ballasting the fluorescent lamps because it eliminates the use of a bulky boost inductor. But the high voltage stress on the semiconductor devices at light load conditions, the high total harmonic distortion (THO) of the line current, and the poor crest factor ( CF) of the lamp current in this circuit make it difficult to manufacture this circuit into a cost-effective ballast product. This thesis analyzes the problems associated with the "charge pump" electronic ballast, and proposes several innovative methods to solve the problems, resulting in a high performance and cost-effective technology.
A 100 Mb/s, 2.8 V CMOS current-mode analogue Viterbi decoder (2001)

We describe a K = 3, rate-1/2 analogue Viterbi decoder fabricated in 0.8µm CMOS technology, intended for convolutional decoding applications. The decoder is the first of its kind to employ current-mode analogue circuit techniques. It operates at data rates of at least 100Mb/s and consumes 40mW at that rate from a single 2.8V power supply. The chip contains about 6K transistors of which less than 1K are used in the analogue sections of the system and has a core area of approximately 1mm 2. 1.
Battery aging detection based on sequential clustering and similarity analysis (2012)

The battery cells are an important part of electric and hybrid vehicles and their deterioration due to aging directly affects the life cycle and performance of the whole battery system. Therefore an early aging detection of the battery cell is an important task and its correct solution could significantly improve the whole vehicle performance. This paper presents a computational strategy for battery aging detection, based on available data chunks from real operation of the vehicle. The first step is to aggregate (reduce) the original large amount of data by much smaller number of cluster centers. This is done by a newly proposed sequential clustering algorithm that arranges the clusters in decreasing order of their volumes. The next step is the proposed fuzzy inference procedure for weighed approximation of the cluster centers that creates comparable one dimensional fuzzy model for each available data set. Finally, the detection of the aged battery is treated as a similarity analysis problem, in which the pair distances between all battery cells are estimated by analyzing the predicted values from the respective fuzzy models. All these three steps of the computational procedure are explained in the paper and applied to real experimental data for battery aging detection. The results are positive and suggestions for further improvements are made in the conclusions.
Human Parvovirus B19 Transgenic Mice Become Susceptible to Polyarthritis (2004)

Human parvovirus B19 (B19) often causes acute polyarthritis in adults. In this paper, we analyzed nucleotide sequences of the B19 genome of patients with rheumatoid arthritis (RA), and then introduced the nonstructural protein 1 (NS1) gene of B19 into C57BL/6 mice that had a genetic origin not susceptible to arthritis. The transgenic mice developed no lesions spontaneously, but were susceptible to type II collagen (CII)-induced arthritis. B19 NS1 was expressed in synovial cells on the articular lesions that were histologically characteristic of granulomatous synovitis and pannus formation in cartilage and bone. Serum levels of anti-CII Abs and TNF-alpha increased in NS1 transgenic mice to the same levels as those of DBA/1 mice, which were susceptible to polyarthritis. Stimulation with CII increased secretion of Th1-type- and Th2-type cytokines in NS1 transgenic mice, indicating that a nonpermissive H-2(b) haplotype in the wild type of C57BL/6 mice can be made susceptible to polyarthritis through the expression of NS1. This study is the first to show that a viral agent from the joints in humans can cause CII-induced arthritis resembling RA.
Live imaging of transforming growth factor‐β activated kinase 1 activation in Lewis lung carcinoma 3LL cells implanted into syngeneic mice and treated with polyinosinic:polycytidylic acid (2016)

Transforming growth factor-β activated kinase 1 (TAK1) has been shown to play a crucial role in cell death, differentiation, and inflammation. Here, we live-imaged robust TAK1 activation in Lewis lung carcinoma 3LL cells implanted into the s.c. tissue of syngeneic C57BL/6 mice and treated with polyinosinic:polycytidylic acid (PolyI:C). First, we developed and characterized a Förster resonance energy transfer-based biosensor for TAK1 activity. The TAK1 biosensor, named Eevee-TAK1, responded to stress-inducing reagents such as anisomycin, tumor necrosis factor-α, and interleukin1-β. The anisomycin-induced increase in Förster resonance energy transfer was abolished by the TAK1 inhibitor (5z)-7-oxozeaenol. Activity of TAK1 in 3LL cells was markedly increased by PolyI:C in the presence of macrophages. 3LL cells expressing Eevee-TAK1 were implanted into mice and observed through imaging window by two-photon excitation microscopy. During the growth of tumor, the 3LL cells at the periphery of the tumor showed higher TAK1 activity than the 3LL cells located at the center of the tumor, suggesting that cells at the periphery of the tumor mass were under stronger stress. Injection of PolyI:C, which is known to induce regression of the implanted tumors, induced marked and homogenous TAK1 activation within the tumor tissues. The effect of PolyI:C faded within 4 days. These observations suggest that Eevee-TAK1 is a versatile tool to monitor cellular stress in cancer tissues.
Hypertension as a predictive marker for bevacizumab in metastatic breast cancer: results from a retrospective matched-pair analysis. (2014)

Bevacizumab in addition to chemotherapy prolonged PFS and OS in a non-selected, partly intensively pre-treated breast cancer population. Hypertension induced by bevacizumab predicted therapy efficacy.
Can people feel happy and sad at the same time? (2001)

The authors investigated whether people can feel happy and sad at the same time. J. A. Russell and J. M. Carroll's (1999) circumplex model holds that happiness and sadness are polar opposites and, thus, mutually exclusive. In contrast, the evaluative space model (J. T. Cacioppo & G. G. Berntson, 1994) proposes that positive and negative affect are separable and that mixed feelings of happiness and sadness can co-occur. The authors both replicated and extended past research by showing that whereas most participants surveyed in typical situations felt either happy or sad, many participants surveyed immediately after watching the film Life Is Beautiful, moving out of their dormitories, or graduating from college felt both happy and sad. Results suggest that although affective experience may typically be bipolar, the underlying processes, and occasionally the resulting experience of emotion, are better characterized as bivariate.
Performance Evaluation of an Intel Haswell-and Ivy Bridge-Based Supercomputer Using Scientific and Engineering Applications (2016)

We present a performance evaluation conducted on a production supercomputer of the Intel Xeon Processor E5-2680v3, a twelve-core implementation of the fourth-generation Haswell architecture, and compare it with Intel Xeon Processor E5-2680v2, an Ivy Bridge implementation of the third-generation Sandy Bridge architecture. Several new architectural features have been incorporated in Haswell including improvements in all levels of the memory hierarchy as well as improvements to vector instructions and power management. We critically evaluate these new features of Haswell and compare with Ivy Bridge using several low-level benchmarks including subset of HPCC, HPCG and four full-scale scientific and engineering applications. We also present a model to predict the performance of HPCG and Cart3D within 5%, and Overflow within 10% accuracy.
Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops (2004)

The biologic effects of endothelin-1 (ET-1) are not limited to its potent vasoconstricting activity. The endothelin receptors, ETA and ETB, have differential tissue and functional distributions. Here we showed that dendritic cells (DCs), the major antigen-presenting cells in the adaptive limb of the immune system, produce large amounts of ET-1 and significantly increase the expression of endothelin receptors upon maturation. Selective blockade of the ETA receptor significantly reduced expression of the mature DC marker CD83, decreased the production of the immunostimulatory cytokine interleukin-12, down-regulated DC ability to stimulate T cells, and promoted DC apoptosis. Selective ETB receptor blockade, on the other hand, resulted in increased expression of CD83 and improved DC survival. Therefore, ET-1/ETA/ETB autocrine/paracrine loops on DCs appear to be essential for the normal maturation and function of human DCs, presenting a unique target for immunomodulatory therapies.
Development of a biochemical process for production of alcohol fuel from peat. Final technical report, June 1, 1981-June 30, 1983 (1983)

This report relates progress in the development of a process for production of mixed alcohol fuel from peat. The process has four steps - pretreatment of peat to promote biodegradability, anaerobic fermentation to produce organic acids, electrolytic oxidation of organic acids to olefins, and hydration of the olefins to alcohols. Since production of alcohols by hydration of olefins is an acknowledged technology, the development program focuses on demonstrating technical feasibility of the other three steps. 70 references, 70 figures, 61 tables.