gebhart/patrepeval huggingface dataset:
Experiments with Simplified Computed-Torque Controllers for Free-Flying Robots (1991)

Base accelerations <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> and base angular velocity in free-flying robots introduce inertial forces not seen in-fixed-base robots. Consequently, dynamic models of free-flying robots possess more degrees of freedom than their fixed-base counterparts. In this paper the effect of neglecting base accelerations in an inertial space endpoint Computed-Torque (CT) controller is examined. Numerical simulations predict a rather wide set of conditions under which CT controllers can neglect base accelerations in their dynamic model with insignificant performance degradation. Two predictions are experimentally verified with a laboratory robot. These two experiments show that negligible additional endpoint controller error results with a simplified CT controller for the given robot mass parameters and manipulator articulation. Modeling error is less than that due to uncertainties in mass distribution and friction effects. A consequence of neglecting robot base accelerations in the simplified CT controller is that Jacobian augmentation terms for momentum control or base control are no longer included. This control will then need to be external to the manipulator controller. On the other hand, a potential saving of an order of magnitude in computation for manipulator control exists.
Polyoxide as an insulator for SiC MOS devices (2005)

Oxide grown from polysilicon, referred to as polyoxide, has been used as an insulating dielectric in silicon-based floating gate MOS devices. However, the properties of polyoxide in SiC MOS devices have rarely been studied. Polyoxide may be used in SiC UMOSFETs to avoid the problems caused by non-uniform native oxide growth in the trench. The other potential benefits of polyoxide include faster oxidation and less carbon involvement. ^ We have produced and characterized MOS capacitors on n-type 4H-SiC with native oxide and polyoxide as insulators. We have observed a lower interface state density for wet oxidation than that for dry oxidation, which also applies to polyoxides. The polyoxide samples grown by dry oxidation without an anneal had a high interface state density (Dit) of 1.8x1012 cm-2 eV-1 and the polyoxide samples grown by wet oxidation had a lower Dit of 1.2x1012 cm -2 eV-1 (both at 0.5 eV below the conduction band). After 1 hour Ar annealing, the Dit of wet polyoxide was reduced significantly to 2.6x1011 cm-2 eV-1 (at 0.5 eV below the conduction band). Dry polyoxide exhibits higher breakdown electric fields than wet polyoxide. The maximum breakdown field for dry polyoxide is 6.1 MV/cm. The maximum breakdown field for wet polyoxide is 4.4 MV/cm. The dielectric strength of the polyoxide is lower than that of the native oxide on SiC. The interface quality and breakdown characteristics of polyoxides are comparable to published results of low-temperature CVD deposited oxides. ^ The better interface quality of wet polyoxides could be related to passivation by H and OH in wet oxidation. The reduction of Dit by high temperature Ar annealing may be associated with stress relaxation and partial removal of interfacial oxide defects. The low breakdown field of polyoxide could be due to the locally enhanced electric fields caused by the rough surface. Further improvement for polyoxide quality is possible with post-oxidation annealing. ^
Histopathological effects of bronchial thermoplasty in different asthma end-types/phenotypes (2022)

Background Bronchial thermoplasty (BT) is a non-pharmacological treatment for severe asthma. It is based on selective heating of the airways aiming to improve asthma symptoms by targeting structural components of the airways. Asthma is considered an umbrella diagnosis for pathologies with distinct mechanistic pathways (endotypes) and clinical presentations (phenotypes) which are key elements for precision medicine in the heterogeneous asthma profiles. The aim of our study was to evaluate the effect of BT on histopathological findings in asthma patients with different endotypes and phenotypes.
Abstract 183: Loss of Bad phosphorylation and Mcl-1 expression is necessary for rapid apoptosisinduced by combination of TGFα-PE and ZSTK474 in prostate cancer cells (2011)

Abstract Advanced androgen-independent prostate cancer is notoriously resistant to conventional systemic therapies, and at the moment there is no effective protocol for hormone-refractory advanced prostate cancer affected patients. One of possible mechanisms of such resistance is activation of the anti-apoptotic signaling PI3K/Akt pathway that is constitutively active in the 60% of advanced prostate cancers. However, multiple inhibitors of PI3K are just well studied and some have just gone on to clinical trials, but unfortunately they showed limited efficacy against prostate cancer alone. Our recent experiments has shown remarkable synergy in inducing rapid and massive apoptosis when PI3K inhibitor ZSTK474 is used in combination with Pseudomonas aeruginosa exotoxin A fragment fused with Transforming Growth Factor Alpha (TGFα-PE38). Time lapse video microscopy of prostate cancer C4-2 cell line has shown the substantial cell death within 4-6 hours with combined administration, compared to limited cell death in single agents-treated cells. Analysis of PARP and cleaved-caspase 3 fragment by Western blotting confirmed that cell death occurs via apoptosis. Quantitation of caspase 3 and 7 activity with luminescent AFC-DEVD substrate confirmed synergy in apoptosis activation by combination of TGFα-PE38 and ZSTK474, while single agents even in higher concentration did not induce substantial apoptosis within 6 hours time period. Analysis of the mechanisms underlying this synergy has shown that PI3K inhibitor ZSTK474 triggers Bad dephosphorylation, while TGFα-PE38 reduces expression levels of Mcl-1. A slight increase of Bim protein was detected and related with ZSTK474 administration. No major variations were detected in the expression levels of pro- and anti-apoptotic proteins Bax, Bcl-2 and Bcl-XL. To address the role of Bad phosphorylation and Mcl-1 expression in apoptosis induction by PI3K inhibitor ZSTK474 and TGFα-PE38, we examined apoptosis in C4-2 cells that express phosphorylation-deficient mutant Bad (BAD2SA). Results indicated that the expression of BAD2SA sensitized C4-2 cells to apoptosis induced by TGFα-PE38. Experiments that address the role of Mcl-1 loss in apoptosis induced by TGFα-PE38 are ongoing. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 183. doi:10.1158/1538-7445.AM2011-183
Fungal metabolites as novel anthelmintics against soil-transmitted helminthes (2015)

It is estimated that over 2 billion people worldwide are suffering from complications due to infections with soil transmitted helminthes (STHs), but very little research is being conducted by human health pharmaceutical companies. In the USA, it is estimated that in distressed areas of poverty, just under 4 million people harbor undiagnosed STH infections.Anthelmintic resistance to broad spectrum compounds has become a worldwide issue. Our initial goal was to screen a unique collection of filamentous fungi and pure isolated fungus metabolites against Brugia malayi microfilaria, Haemonchus contortus L1 and Strongyloides stercoralis L3. We confirmed a number of active fungi against all three targets. Many of these active extracts were produced by cultures not previously shown to produce anthelmintic metabolites. De-replication procedures demonstrated metabolite novelty. Of the 90 pure compounds tested, we identified active metabolites against all three target species. One of the active pure compounds identified was enniatin D which belongs to a structure class known to have anthelmintic activity, thereby validating the approach.
The future of clinical trials in secondary prevention after acute coronary syndromes (2010)

\n Contains fulltext :\n 97431.pdf (Publisher’s version ) (Closed access)\n
Creatr, a genergtic graphical distributed debugger with language support for application interfacing (1994)

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1994.
A Low-Cost System for Wind Field Estimation Through Sensor Networks and Aircraft Design (2015)

Multi-hole probes have been used on small aircraft for accurate wind measurements. However, these probes have three main issues associated with them: 1) they are relatively bulky, 2) they are relatively expensive (compared to the cost of the airframe that might carry them) and 3) they need to be placed in the free stream with minimal influence from the airframe. An alternative pressure-measurement-based solution is proposed that uses low-cost pressure sensors located on the airframe at locations most sensitive to the angular orientation, relative to the cruise attitude. The RECUV Eagle Owl UAS airframe is used as a demonstration platform. CFD results are presented to illustrate the process for determining surface locations for a prescribed number of pressure sensors corresponding to the highest sensitivity in estimating angle of attack and side slip. An update is provided on the assembly of a wind tunnel model to be used for calibration prior to test flights.
ChemInform Abstract: Phosphorylation of Phenols and Naphthols by Phenyl‐methylenephosphine Oxide Generated by the Thermolysis of a 2‐Phosphabicyclo[2.2.2]octa‐5,7‐diene 2‐Oxide. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
New dynamic SPT algorithm based on a ball-and-string model (2001)

A key functionality in today's widely used interior gateway routing protocols such as OSPF and IS-IS involves the computation of a shortest path tree (SPT). In many existing commercial routers, the computation of an SPT is done from scratch following changes in the link states of the network. As there may coexist multiple SPTs in a network with a set of given link states, such recomputation of an entire SPT not only is inefficient but also causes frequent unnecessary changes in the topology of an existing SPT and creates routing instability. This paper presents a new dynamic SPT algorithm that makes use of the structure of the previously computed SPT. Our algorithm is derived by recasting the SPT problem into an optimization problem in a dual linear programming framework, which can also be interpreted using a ball-and-string model. In this model, the increase (or decrease) of an edge weight in the tree corresponds to the lengthening (or shortening) of a string. By stretching the strings until each node is attached to a tight string, the resulting topology of the model defines an (or multiple) SPT(s). By emulating the dynamics of the ball-and-string model, we can derive an efficient algorithm that propagates changes in distances to all affected nodes in a natural order and in a most economical way. Compared with existing results, our algorithm has the best-known performance in terms of computational complexity as well as minimum changes made to the topology of an SPT. Rigorous proofs for correctness of our algorithm and simulation results illustrating its complexity are also presented.
Diccionario sistemático de los determinadores temporales en español y sus correlatos ingleses (2009)

Sobre la base de una serie de trabajos que describian el sistema de la determinacion temporal del enunciado, los autores presentan ahora, publicado en cuatro partes, un diccionario de los determinadores con sus correlatos ingleses. Cada entrada consta de un lema, que recoge su valor en el conjunto del sistema, y su correspondiente definicion mediante 1) el valor determinativo de cada determinador en la estructura performativa del enunciado, 2) un ejemplo aclaratorio, y 3) sus marcas semantico-pragmaticas.
Synthesis of aluminum oxides from the products of the rapid thermal decomposition of hydrargillite in a centrifugal flash reactor: II. Physicochemical properties of the products obtained by the centrifugal thermal activation of hydrargillite (2007)

A variety of physicochemical methods were used to characterize the product of the rapid thermal decomposition of hydrargillite in a centrifugal flash reactor under the following conditions: the average particle size of the reactant, 80–120 μm; the temperature of the solid heating surface (plate or cylinder), 300–700°C; hot-zone residence time, ∼1 s; transfer of the product to the cooled zone of the reactor. The composition of the product and the extent of decomposition of hydrargillite were determined as a function of the processing temperature. The centrifugal thermal activation (CTA) of hydrargillite affords an X-ray-amorphous, highly reactive product with a developed surface and a disordered and inhomogeneous porous structure. This structure is capable of forming different modifications of aluminum hydroxide and oxide. The properties of the CTA product are compared with the properties of the earlier reported hydrargillite rapid decomposition products obtained using a gaseous heat-transfer agent (thermochemical activation product) or a fluidized bed of a granular heat-transfer agent (thermal dispersion product).
Non-transcribed strand repair revealed in quiescent cells (2006)

Stem cells, one of the progenitors of cancer, exist predominately in a quiescent state. Thus, understanding the mechanisms of DNA repair and mutagenesis in such arrested cells may help unravel the complex process of tumorigenesis. Two major nucleotide excision repair (NER) pathways are known to remove bulky physical or chemical lesions from DNA. Transcription-coupled repair (TCR) acts solely on the transcribed strand of expressed genes, while global genomic repair (GGR) is responsible for the ubiquitous repair of the genome. Indirectly, it has been shown that while TCR functions in quiescent cells GGR does not. To explicitly elucidate this phenomenon, we adapted a quantitative PCR (QPCR) assay to study UV-damage repair via TCR and GGR in quiescent and proliferating cells. We present evidence that repair of untranscribed silent regions of the genome and repair of the non-transcribed strand of active genes proceeds by two discrete mechanisms in quiescent cells; rather than by GGR, which was believed to encompass both. Thus, our findings suggest the existence of an alternate NER pathway in quiescent cells. The proposed subcategories of NER are as follows: (i) TCR, responsible for maintenance of transcribed strands; (ii) GGR, responsible for ubiquitous genome repair; and (iii) non-transcribed strand repair (NTSR), predominantly responsible for the repair of the NTS in arrested cells. In quiescent cells, it is evident that TCR and NTSR function and GGR are arrested. As a consequence, mutation accumulation at temporally silent genes and incomplete or imperfect repair of transcribed genes, in quiescent stem cells, may provide a source of cancer causing mutations.
First record of Pinctada radiata (Bivalvia, Pteriidae) epibiont on the loggerhead sea turtle Caretta caretta (Chelonia, Cheloniidae) (1992)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
An Overview on Privacy Preserving Biometrics (2011)

The Internet has consolidated itself as a very powerful platform that has changed the communication and business way. Nowadays, the number of users navigating through Internet is about 1,552 millions according to Internet World Stats. This large audience demands online commerce, e-government, knowledge sharing, social networks, online gaming . . . which grew exponentially over the past few years. The security of these transactions is very important considering the number of information that could be intercepted by an attacker. Within this context, authentication is one of the most important challenges in computer security. Indeed, the authentication step is often considered as the weakest link in the security of electronic transactions. In general, the protection of the message content is achieved by using cryptographic protocols that are well known and established. The well-known ID/password is far the most used authentication method, it is widely spread despite its obvious lack of security. This is mainly due to its implementation ease and to its ergonomic feature: the users are used to this system, which enhances its acceptance and deployment. Many more sophisticated solutions exist in the state of the art to secure logical access control (one time passwords tokens, certificates . . . ) but none of them are used by a large community of users for a lack of simplicity usage (O'Gorman, 2003)...
Die Verträglichkeit von Hydroxypropylmethylcellulose bei der Implantation von Hinterkammer-Linsen* (1988)

In 65 patients, the safety of a 2% solution of hydroxypropylmethylcellulose (HPMC) was investigated by comparing HPMC with a balanced salt solution during posterior chamber lens implantation. The controlled open randomized trial consisted of two groups of patients: 1) in 37 patients the surface of the implant was coated with HPMC and the inner wound sealed prior to insertion; 2) in the control group with 28 patients the lens was dipped in the balanced salt solution. There were no statistically significant differences between the two groups as regards any of the characteristics investigated, such as visual acuity, intraocular pressure, corneal thickness, endothelial cell loss, and postoperative irritation within the anterior chamber. There was no rise in mean intraocular pressure in the HPMC group on the first postoperative day, and a rise of 1 mm Hg in the control group. The increase in corneal thickness on the first postoperative day in the HPMC group was 0.07 and in the control group 0.04 mm. At re-examination (50th postoperative day) the mean thickness in both groups was identical to the initial values. The mean endothelial cell loss at re-examination was 18% (+/- 16%). No serious side effects were observed. HPMC may be regarded as a well-tolerated viscoelastic substance.
Tuning bad metal and non-Fermi liquid behavior in a Mott material: Rare-earth nickelate thin films (2015)

Resistances that exceed the Mott-Ioffe-Regel limit (known as bad metal behavior) and non-Fermi liquid behavior are ubiquitous features of the normal state of many strongly correlated materials. We establish the conditions that lead to bad metal and non-Fermi liquid phases in NdNiO3, which exhibits a prototype bandwidth-controlled metal-insulator transition. We show that resistance saturation is determined by the magnitude of Ni eg orbital splitting, which can be tuned by strain in epitaxial films, causing the appearance of bad metal behavior under certain conditions. The results shed light on the nature of a crossover to a non-Fermi liquid metal phase and provide a predictive criterion for Anderson localization. They elucidate a seemingly complex phase behavior as a function of film strain and confinement and provide guidelines for orbital engineering and novel devices.
Expression of amyloid precursor protein (APP) in rat brain and cultured neural cells (1994)

Cell type-specific and developmental patterns of APP expression were investigated in rat brain and cultured neural cells. Nearly all astrocytes were APP-positive, whereas only selected population of neurons appeared to express APP. In these neurons, APP immunoreactivity was preferentially restricted to single processes. mRNAs encoding the major APP isoforms, APP695 and APP770, were co-expressed as 3.4-3.6 kb transcripts both in astrocytes and neurons. In addition, an unusual 2.8 kb mRNA size class was revealed in cultured cerebellar granule neurons by means of the probe recognizing APP770 mRNA. Also, for the first time, APP714 mRNA was detected in rat brain by northern blotting. The steady-state levels of these transcripts were increased from birth up to postnatal day 20, whereas no apparent changes were observed after reaching adulthood. These data hint at the involvement of APP in the major morphogenetic events taking place in rat brain during the first three postnatal weeks.
Transmembrane signal transduction and osmoregulation in Escherichia coli. Functional importance of the periplasmic domain of the membrane-located protein kinase, EnvZ. (1991)

The EnvZ protein is presumably a membrane-located osmotic sensor which is involved in expression of the ompF and ompC genes in Escherichia coli. Previously, we developed an in vitro method for analyzing the intact form of the EnvZ protein located in isolated cytoplasmic membranes, and demonstrated that this particular form of the EnvZ protein exhibits the ability not only as to OmpR phosphorylation but also OmpR dephosphorylation. In this study, to gain an insight into the structural and functional importance of the putative periplasmic domain of the EnvZ protein, a set of mutant EnvZ proteins, which lack various portions of the periplasmic domain, were characterized in terms of not only their in vivo osmoregulatory phenotypes but also in vitro EnvZ-OmpR phosphotransfer reactions. It was revealed that these deletion mutant EnvZ proteins are normally incorporated into the cytoplasmic membrane. Cells harboring these mutant EnvZ proteins showed a pleiotropic phenotype, namely, OmpF- Mal- LamB- PhoA-, and produced the OmpC protein constitutively irrespective of the medium osmolarity. It was also suggested that all of these mutant EnvZ proteins were defective in their in vitro OmpR dephosphorylation ability, while their OmpR phosphorylation ability remained unaffected. These results imply the functional importance of the periplasmic domain of the EnvZ protein for modulation of the kinase/phosphatase activity exhibited by the cytoplasmic domain in response to an environmental osmotic stimulus.
Scan Integrity Tests for EDT Compression (2020)

Scan chains are the fundamental building blocks for DFT, and testing for scan integrity is the first step in a robust test methodology. This article describes scan integrity tests for embedded test compression structures.
Zur Stereochemie der aromatischen CLAISEN‐Umlagerung (1969)

Abstract The possible transition state conformations (chair ( S ), boat ( W ), and twist ( T ), respectively cross ( K ) forms) and methods for their determination in the thermal ortho ‐C LAISEN rearrangement of allyl aryl ethers are discussed. Crotyl 3,5‐dimethylphenyl ether ( 11 ) gives a mixture of 2‐(α‐methylallyl)‐3,5‐dimethyl‐phenol ( 12 ) and 4‐crotyl‐3,5‐dimethyl‐phenol ( 13 ) on heating in N, N‐diethylaniline. Values of 3 and 31 were obtained for the ratio of 12 / 13 for trans ‐ 11 and cis ‐ 11 , respectively. It therefore follows that both ethers rearrange steroselectively ( &gt; 90%) by the S or W forms of the activated complex. αMethylallyl 6‐alkylphenyl ethers rearrange on heating in various solvents to a mixture of trans ‐and cis ‐2‐crotyl‐6‐alkyl‐phenols. The amount of the cis ‐phenols in the rearrangement products decreases with the increasing bulk of the 6‐alkyl substituent. This result is only obvious if the chair form of the transition state during the rearrangement of these ethers is highly favoured. trans ‐Crotyl 2,6‐dimethylphenyl ether ( trans ‐ 33 ) rearranges highly steroselectively (94%) on heating to trans ‐4‐crotyl‐2,6‐dimethyl‐phenol ( trans ‐ 34 ). In the case of the corresponding cis ether 33 , the rapid cis → trans isomerisation of this ether and the cis / trans ratio of the phenol 34 indicate that the reverse rearrangement of the intermediate ortho ‐dienone to the ether 33 and the further rearrangement to 4‐crotyl‐2,6‐dimethyl‐phenol ( 34 ) has little stereoselective character.