gebhart/patrepeval huggingface dataset:
Hybrid Solar-Geothermal Energy Absorption Air-Conditioning System Operating with NaOH-H2O—Las Tres Vírgenes (Baja California Sur), “La Reforma” Case (2018)

Solar and geothermal energies are considered cleaner and more useful energy sources that can be used to avoid the negative environmental impacts caused by burning fossil fuels. Several works have reported air-conditioning systems that use solar energy coupled to geothermal renewable energy as a thermal source. In this study, an Absorption Air-Conditioning System (AACS) used sodium hydroxide-water (NaOH-H2O) instead of lithium bromide-water to reduce the cost. Low enthalpy geothermal heat was derived from two shallow wells, 50 and 55 m deep. These wells are of interest due to the thermal recovery (temperature vs. time) of 56.2 °C that was possible at the maximum depth, which can be used for the first stage of the process. These wells were coupled with solar energy as a geothermal energy application for direct uses such as air-conditioning systems. We studied the performance of an absorption cooling system operating with a NaOH-H2O mixture and using a parabolic trough plant coupled with a low enthalpy geothermal heat system as a hybrid heat source, as an alternative process that can help reduce operating costs and carbon dioxide emissions. The numerical heat transfer results showed the maximum convective heat transfer coefficient, as function of fluid velocity, and maximum temperature for a depth higher than 40 m. The results showed that the highest temperatures occur at low fluid velocities of less than or equal to 5.0 m/s. Under these conditions, reaching temperatures between 51.0 and 56.2 °C in the well was possible, which is required of the geothermal energy for the solar energy process. A water stream was used as the working fluid in the parabolic trough collector field. During the evaluation stage, the average experimental storage tank temperature achieved by the parabolic trough plant was 93.8 °C on October 23 and 92.9 °C on October 25, 2017. The numerical simulation used to evaluate the performance of the absorption cycle used a generator temperature of 90 °C, a condenser and absorber temperature at 35 °C, and an evaporator temperature of 10 °C. The Coefficient of Performance was calculated as 0.71 under design conditions.
Data from A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Human telomerase reverse transcriptase (hTERT) is highly expressed in &gt;85% of human tumors and is thus considered as a good tumor-associated antigen candidate for vaccine development. We conducted a phase I study to investigate the safety, tolerability, clinical response, and immunogenicity of INVAC-1, a DNA plasmid encoding a modified hTERT protein in patients with relapsed or refractory solid tumors.&lt;/p&gt;Patients and Methods:&lt;p&gt;INVAC-1 was either administered by intradermal route followed by electroporation or by Tropis, a needle-free injection system. Safety and tolerability were monitored by clinical and laboratory assessments. Progression-free survival and overall survival were reported using Kaplan–Meier survival analysis. Immunogenicity was studied by ELISpot, Luminex, and Flow Cytometry.&lt;/p&gt;Results:&lt;p&gt;Twenty-six patients were treated with INVAC-1 administered at three dose levels (100, 400, and 800 μg). Vaccination was well tolerated and no dose-limiting toxicity was reported. One treatment-related grade 3 SAE was reported. Fifty-eight percent of patients experienced disease stabilization. PFS was 2.7 months, median OS was 15 months, and 1-year survival was reached for 65% of patients. INVAC-1 vaccination stimulated specific anti-hTERT CD4 T-cell response as well as cytotoxic CD8 T-cell response. No evidence of peripheral vaccine-induced immunosuppression was observed.&lt;/p&gt;Conclusions:&lt;p&gt;INVAC-1 vaccination was safe, well tolerated, and immunogenic when administered intradermally at the three tested doses in patients with relapsed or refractory cancers. Disease stabilization was observed for the majority of patients (58%) during the treatment period and beyond.&lt;/p&gt;&lt;p&gt;&lt;i&gt;See related commentary by Slingluff Jr, p. 529&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
A learning agent that acquires social norms from public sanctions in decentralized multi-agent settings (2023)

Society is characterized by the presence of a variety of social norms: collective patterns of sanctioning that can prevent miscoordination and free-riding. Inspired by this, we aim to construct learning dynamics where potentially beneficial social norms can emerge. Since social norms are underpinned by sanctioning, we introduce a training regime where agents can access all sanctioning events but learning is otherwise decentralized. This setting is technologically interesting because sanctioning events may be the only available public signal in decentralized multi-agent systems where reward or policy-sharing is infeasible or undesirable. To achieve collective action in this setting, we construct an agent architecture containing a classifier module that categorizes observed behaviors as approved or disapproved, and a motivation to punish in accord with the group. We show that social norms emerge in multi-agent systems containing this agent and investigate the conditions under which this helps them achieve socially beneficial outcomes.
A Systematic Review on the Role of Vitamin C in Tissue Healing (2022)

Vitamin C is an essential nutrient for humans and animals which are unable to synthesise it themselves. Vitamin C is important for tissue regeneration due to the role it plays in collagen formation, and its antioxidant properties. We reviewed the literature to evaluate potential associations between vitamin C supplementation and healing of an acute or chronic condition. Embase, Medline, PubMed, and the Cochrane Library were searched for studies published prior to April 2022. Studies were eligible if they reported at least one association between vitamin C supplementation and healing outcomes. Eighteen studies met the inclusion criteria and were included in this review. Overall, vitamin C supplementation improved healing outcomes in certain pathologies, predominantly pressure ulcers. However, many of the studies had small sample sizes, combined nutritional treatments, and did not test baseline vitamin C. Future studies should be of larger scale, exclusively using vitamin C to determine its role in tissue healing in other wounds. We recommend consideration of vitamin C supplementation for people with pressure ulcers.
Evaluation of an isolation and maintenance medium for Actinomyces species and related organisms. (1959)

Abstract A laboratory medium satisfactory for the isolation and maintenance of Actinomyces is described. This medium has been compared to brain heart infusion agar and Garrod's starch medium for maintenance and isolation of Actinomyces from clinical material. The Actinomyces medium is superior for maintenance and allows maximum growth of all the strains tested. It also supports excellent growth of Corynebacteria acnes, C. liquefaciens, Lactobacillus bifidus , and Leptotrichia buccalis .
A Subharmonically Injection-Locked All-Digital PLL Without Main Divider (2015)

A subharmonically injection-locked all-digital phaselocked loop (ADPLL) without a main divider is presented. It achieves not only low power but also low phase noise over the process, voltage, and temperature (PVT) variations. This ADPLL uses only a simple bang-bang phase detector without a time-todigital converter when both frequency and phase locking. Moreover, the injection pulse can be self-adjusted to optimal timing over the PVT variations without additional calibration loop. This ADPLL is fabricated in a 40-nm CMOS process; it consumes 3.04 mW under a standard supply of 1.1 V excluding output buffers. The measured phase noise of the proposed ADPLL is -121.4 dBc/Hz at 1-MHz offset. The integrated RMS jitter is 109.6 fs for the offset frequency from 1 kHz to 100 MHz. The calculated figure-of-merit is equal to -254.39 dB.
Chapter 3: Parameter Identification: Continuous Time (2006)

3.1 Introduction
Structure of a cyclin-dependent kinase fromGiardia lamblia (2011)

Giardia lamblia is the etiologic agent of giardiasis, a water-borne infection that is prevalent throughout the world. The need for new therapeutics for the treatment of giardiasis is of paramount importance. Owing to the ubiquitous nature of kinases and their vital importance in organisms, they are potential drug targets. In this paper, the first structure of a cyclin-dependent kinase (CDK) from G. lamblia (GlCDK; UniProt A8BZ95) is presented. CDKs are cell-cycle-associated kinases that are actively being pursued as targets for anticancer drugs as well as for antiparasitic chemotherapy. Generally, a CDK forms a complex with its associated cyclin. This CDK-cyclin complex is active and acts as a serine/threonine protein kinase. Typically, CDKs are responsible for the transition to the next phase of the cell cycle. Although the structure of GlCDK with its associated cyclin was not solved, the 1.85 Å resolution structure of apo GlCDK and a 2.0 Å resolution structure of GlCDK in complex with adenosine monophosphate are presented and the structural differences from the orthologous human CDK2 and CDK3 are discussed.
Utilization of Molecular Simulation Software Gaussian 03 to Design Absorbent for CO2 Capture (2011)

A preliminary study on the interaction between molecules of absorbent for CO2 absorption was undertaken using Gaussian 03 molecular simulation software. The results indicate that the molecular interaction energy has strong correlations with Henry's constant. The lower interaction energy between molecules, solvent molecules form an “associated complex” more stability, and therefore the worse the effect of CO2 absorption.
Signal-amplifying nanoparticle/hydrogel hybrid microarray biosensor for metal-enhanced fluorescence detection of organophosphorus compounds (2018)

In this study, we developed an enzyme-based miniaturized fluorescence biosensor to detect paraoxon, one of the most well-known neurotoxic organophosphorus compounds. The biosensor was fabricated with poly(ethylene glycol) (PEG) hydrogel microarrays that entrapped acetylcholinesterase (AChE) and quantum dots (QDs) as fluorescence reporters. Metal-enhanced fluorescence (MEF) was utilized to amplify the fluorescence signal, which was achieved by decorating QDs on the surface of silica-coated silver nanoparticles (Ag@Silica). The MEF effects of Ag@Silica were optimized by tuning the thickness of the silica shells, and under the optimized conditions, the fluorescence intensity was shown to be increased 5 fold, compared with the system without MEF. PEG hydrogel microarray entrapping QD-decorated Ag@Silica and AChE was prepared via photopatterning process. The entrapped AChE hydrolyzed paraoxon to produce p-nitrophenol within the hydrogel microstructure, which subsequently quenched the fluorescence of the QDs on the surface of Ag@Silica. The MEF-assisted fluorescence detection resulted in a significant enhancement of paraoxon detection. The detection limit was approximately 1.0 × 10<sup>-10</sup> M and 2.0 × 10<sup>-7</sup> M for sensing with and without MEF, respectively. The successful integration of a hydrogel microarray system with a microfluidic system was demonstrated to be a potential application for the MEF-based micro-total-analysis-system.
Model predictive control for perturbed max-plus-linear systems: a stochastic approach (2002)

Model predictive control (MPC) is a popular controller design technique in the process industry. Conventional MPC uses linear or nonlinear discrete-time models. Previously, we (2001) have extended MPC to a class of discrete event systems that can be described by a model that is "linear" in the (max, +) algebra. In our previous work we have only considered MPC for the perturbations-free case and for the case with bounded noise and/or modeling errors. We extend our previous results on MPC for perturbed max-plus-linear systems to a stochastic setting. We show that under quite general conditions the resulting optimization problems turn out to be convex and can be solved very efficiently.
Interaction acoustic radiation force and torque on a cluster of spheres suspended in an inviscid fluid (2014)

The acoustic radiation force and torque exerted by a time-harmonic beam of arbitrary wavefront on a cluster of suspended spheres in an inviscid fluid is theoretically analyzed. In the proposed method, the effective incident wave is modelled as a coherent sum of an external beam and the contributions from the re-scattering events by other spheres present in the medium. Using the translational addition theorem for spherical functions the effective beam-shape and scattering coefficients are numerically computed [J. Acoust. Soc. Am. 98, 495 (1995)] for different external incident fields. The radiation force and torque exerted on the probe sphere can then be calculated using the farfield partial-wave expansion method [J. Acoust. Soc. Am. 130, 3541 (2011); Europhys. Phys. Lett. 97, 54003 (2012)]. The method was employed to obtain the radiation force due to an external plane and spherical waves on a cluster of three solid elastic or fluid spheres suspended in water. The results show that the radiation force deviates considerably from that exerted solely by the external incident wave and that the radiation torque arises on the spheres when a asymmetric spatial distribution of the effective incident acoustic field takes place in the medium. In addition, the proposed method may help on the study of acoustic tweezers devices and acoustofluidic systems, which involve several suspended particles.
Studies on chemical constituents of the leaves of Smallantus sonchifolius (yacon): Structures of two new diterpenes (2009)

The extract from the leaves of Smallantus sonchifolius (yacon) was found to show potent anti-diabetic activity. Two new diterpenes, named ent-kaurane-3beta,16beta,17, 19-tetrol (1) and ent-kaurane-16beta,17,18,19-tetrol (2), were isolated from the extract, together with six known compounds. The structures of the new compounds were determined on the basis of chemical and physicochemical evidence.
Dietary- and tissue-based exposure of belted kingfisher to PCDFs and PCDDs in the Tittabawassee River floodplain, Midland, MI, USA (2012)

Concentrations of polychlorinated dibenzofurans (PCDFs) and other dioxin-like compounds in soils and sediments of the Tittabawassee River and associated floodplains downstream of Midland, Michigan, USA, are greater than upstream sites. As a result of these concentrations, which are some of the greatest ever reported, a site-specific exposure assessment of belted kingfisher breeding in the assessment area was conducted. To reduce the uncertainty associated with predicting exposure from abiotic matrices, concentrations of residues were quantified in site-specific prey items and in eggs and nestlings of belted kingfisher. Dietary exposure, expressed as the potential average daily dose, based on site-specific concentrations of PCDFs, polychlorinated dibenzo-p-dioxins (PCDDs), and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TEQ(WHO-Avian)) in prey items was consistently greater along the Tittabawassee River than in associated reference areas and further downstream sites in the Saginaw River. Concentrations of PCDD/DFs in eggs and nestlings of belted kingfisher varied among sampling areas, being greater in both eggs and nestlings nesting along the Tittabawassee River compared to those of belted kingfisher from upstream reference areas. Geometric mean concentrations of PCDD/DFs were 130 and 200 ng/kg wet weight in eggs and nestlings of belted kingfisher, respectively. These concentrations are the equivalent of 84 and 95 ng TEQ(WHO-Avian)/kg. Site-specific biomagnification factors for select PCDD/DF congeners ranged from <1.0 to 1.8 in belted kingfisher.
Table S4 from Field Synopsis of Environmental and Genetic Risk Factors of Sporadic Early-Onset Colorectal Cancer and Advanced Adenoma (2023)

&lt;p&gt;Supplementary Table 4 shows the list of environmental risk factors and their associations with early-onset colorectal advanced adenomas (EOCRA).&lt;/p&gt;
Propidium iodide and the thiol‐specific reagent dacm as a dye pair for fluorescence resonance energy transfer analysis: An application to mouse sperm chromatin (1994)

The dyes N-(-7-dimethyl-amino-4-methyl-coumarinyl) maleimide and propidium iodide, specific for the thiol group and DNA, respectively, were considered as a donor-acceptor couple suitable for investigating "in situ" the relative spatial distribution of DNA and protamines in mouse spermatozoa chromatin. The two dyes are characterized by favourable spectral properties, so that a simplified analytical procedure, based on the measurement of both donor and acceptor emission in double-stained samples, can be applied to evaluate the relative efficiency of the energy transfer process and its topological distribution. The results obtained indicate that during the maturation process: 1) the basic arrangement of protamine-DNA complex does not undergo structure changes, and 2) the oxidation of sulfhydryl to disulfide groups, resulting in chromatin stabilization, first involves the protamine thiols spatially closer to DNA. Fluorescence energy transfer imaging suggests that chromatin stabilization starts in the midportion of the sperm head, then spreads towards the periphery.
Direct Laser Patterning of a Gas Sensor on Flexible Substrate (2014)

Flexible gas sensor fabricated by direct laser patterning and its gas sensing properties towards ozone and ammonia are reported. The flexible platform consists in Ti/Pt interdigited electrodes for gas detection and a microheater device. The platform validation has been realized by thermal simulation and its electrical properties have been also studied. The gas sensing properties were investigated using a commercial ink of ZnO nanoparticles at several concentrations and temperatures. The sensor presents excellent responses toward ammonia and ozone at 300 °C and 200 C° respectively, with good reproducibility, and fast response and recovery time in a wide range of concentrations.
Synthesis of Optically Active Prostaglandin‐J2 and 15‐Deoxy‐Δ12,14‐prostaglandin‐J2. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Effect of end‐tidal carbon dioxide level on the optic nerve sheath diameter measured by transorbital ultrasonography in anesthetized pediatric patients: A randomized trial (2022)

The optic nerve sheath diameter measured by transorbital ultrasound showed rapid reactivity from E<sub>T</sub> CO<sub>2</sub> 35 to 45 mmHg in healthy pediatric patients under inhalation general anesthesia.
Application of the PredictAD Decision Support Tool to a Danish Cohort of Patients with Alzheimer's Disease and Other Dementias (2013)

In this dataset, the DSI method used by the PredictAD tool showed a superior performance for the differentiation between patients with AD and those with other dementias. However, the methods need to be refined further in order to optimize the differential diagnosis between AD, FTD, VaD and DLB.
Photo-cleavable purification/protection handle assisted synthesis of giant modified proteins with tandem repeats (2019)

Proteins with tandem repeats have essential physical or biological roles in cells and have been widely investigated as biomaterials or vaccines. Chemically derived proteins with tandem repeats would be beneficial for research, owing to their accurate structures, possibly with precise modifications, produced by chemical synthesis. Traditional protein synthesis often leads to severe handling loss due to multiple ligations and HPLC purifications. To improve the protein synthesis efficiency, we developed a purification/protection handle consisting of a His<sub>6</sub> tag and a photo-labile linker. This handle has great potential to facilitate purification with immobilized metal affinity chromatography techniques and also provides orthogonal protection for N-terminal Cys. The synthesis of the model proteins Muc1 and antifreeze glycoprotein mimics shows that the handle decreases the requirement for HPLC and enables both convergent and sequential assembly of peptide segments.
L’accentuation des pronoms personnels en français standard, by Monique Léon (Studia phonetica, 5). Montréal-Paris-Bruxelles: Didier, 1972. Pp. xiii + 137. (1973)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
645: Biopsy Indication - A Predictor of Pathological Stage Among Men with Pre-Operative Serum PSA Levels <4.0 NG/ML and T1C Disease (2004)

was extracted from these epithelial cells. Using SAGE database or the available literature, 11 promising genes (PSA, PAP, PSMA, HK2, NKX3.1 PSCA, PSTG, DD3, PSGR, AMACR and EZH2) were selected based on their relative abundance of expression, prostate tissue specificity and prostate cancer specificity.
Rheological Properties of Liquid Crystalline Solutions of Poly‐p‐Phenyleneterphthalamide in Sulfuric Acid (1980)

The steady state shear and linear viscoelastic properties of both isotropic and liquid crystalline solutions of the rigid chain polymer poly-p-phenyleneterephthalamide in sulfuric acid have been determined. Both the primary normal stress coefficient and the linear viscoelastic properties show the same characteristic concentration behavior as does the viscosity. The unique rheological properties ofthe anisotropic phase can be attributed to the formation of a suspension of highly ordered regions in a matrix of isotropic fluid. The rheological properties were compared against the Bird-Carreau model and Hand's anisotropic fluid theory. Remarkably good agreement was found between the Bird-Carreau model and data especially at highs hear rates. This suggested that at high shear rates very little difference may exist between anisotropic and isotropic phases. Hand's model was more applicable to solutions which were only slightly anisotropic.
Effect of gate field plate and Γ(gamma)-gate structures on RF power performance of AlGaN/GaN HEMTs (2015)

In this work, effect of field plate and Γ(gamma)-gate structures on RF power performance of AlGaN/GaN high electron mobility transistors (HEMTs) are reported. 3 μm drain source space, 0.6 μm gate length AlGaN/GaN HEMTs with field plate length of 0.5 μm and Γ-gate head length of 1.2 μm (with the 0.5 μm field plate length) have been fabricated. At 8 GHz with a drain bias of 25 V, for field plate and Γ-gate 0.6nm × 8 × 125μm HEMTs, small gain of 10,5 dB and 10,9 dB, at 3dB gain compression a continuous wave output power of 35.5 dBm and 36.7 dBm, power-added efficiency (PAE) of 43.4% and 43.2% are measured respectively. For Γ-gate 0.6μm× 8×250 μm AlGaN/GaN HEMTs, with drain bias of 50V, an output power of 40.83 dBm (6,05 W/mm) and PAE of 30% at 8 GHz and an output power of 41.22 dBm (6,64 W/mm) and PAE of 50,3% at 2 GHz have also been obtained without using via hole technology.