gebhart/patrepeval huggingface dataset:
Survival During Frozen and Subsequent Refrigerated Storage of Lactobacillus acidophilus Cells as Influenced by the Growth Phase (1995)

Cells of Lactobacillus acidophilus propagated in peptonized milk nutrient broth maintained at pH 5 were harvested during the late logarithmic (log) phase and at 6 h into the stationary phase of growth. Concentrated cultures were prepared from each age of cells, frozen, and stored at -196 degrees C. The concentrated cultures were assayed for numbers of total and bile-tolerant lactobacilli, beta-galactosidase activity, and ability to assimilate cholesterol before and after storage at -196 degrees C. Nonfermented acidophilus milk, prepared following 28 d of storage at -196 degrees C from each concentrated culture, was tested before and after 0, 7, 14, 21, and 28 d of storage at 7 degrees C. No decrease in numbers of total or bile-tolerant lactobacilli, beta-galactosidase activity, or amount of cholesterol assimilated was observed for any of three strains studied during storage at -196 degrees C. There were no significant differences between the two harvest times during storage at this temperature for any of the three strains. However, when the cells were suspended in milk and stored at 7 degrees C, the numbers of total and bile-tolerant lactobacilli declined over time as did the beta-galactosidase activity and the ability to assimilate cholesterol. The cells from L. acidophilus 223, harvested 6 h into the stationary phase, exhibited significantly less decrease in total numbers during extended storage at 7 degrees C than did the cells harvested in the late logarithmic phase. There was little or no difference in the decline in numbers of total lactobacilli between the two harvest times for strains 606 and 107. All strains decreased significantly in beta-galactosidase activity and the ability to assimilate cholesterol during storage in milk at 7 degrees C with no significant differences between the two harvest times.
Double Femtosecond Pulses Mode-Locked Ti:Sapphire Oscillator (2007)

We demonstrate a simple method to control the spectrum and to generate synchronized double femtosecond pulses in a mode-locked Ti:Sapphire laser. And the difference of two wavelengths is easily tuned in large range..
Monitoring of β-blockers ozone degradation via electrospray ionization mass spectrometry (2011)

The structures of intermediate products of ozone degradation of different pharmaceutical compounds have been studied. Under the conditions employed, complete ozone degradation of nadolol was achieved after 100 min. The degradation products obtained in aqueous solution were characterized by electrospray ionization mass (and tandem mass) spectrometry (ESI-MS and ESI-MS/MS). The proposed mechanism for degradation, ozone attacks at the aniline amino group giving rise to nitro compounds and further degradation occurs via a series of oxidative processes. Continuous online monitoring by ESI-MS(/MS) with high accuracy mass measurements showed that ozone degradation of atenolol (ATE) and acebutolol (ACE) occurs via mechanisms similar to that of nadolol
Zur Fehlordnung im System Li1+xMn2-yO4-d (2001)

Lithiummanganoxid ist bekannt als preiswertes und ungiftiges Elektrodenmaterial in sekundären Lithiumionenzellen. Das Spinellsystem (Li1+xMn2-yO4-d) kristallisiert bei Zimmertemperatur in der Raumgruppe Fd-3m. Das Zyklenverhalten dieser Substanz in einer Batterie ist von großem wirtschaftlichen Interesse bei der Produktion von Batteriezellen. Es wurde gezeigt, dass zusätzlich eingebautes Lithium die Zyklenstabilität signifikant erhöht. In dieser Arbeit wurde Spinellmaterial mit unterschiedlichen Lithiumüberschußgehalten hergestellt und durch Röntgen- und Neutronenpulverbeugung charakterisiert. Die Röntgenabsorption (EXAFS) wurde zur detaillierten Betrachtung der Intercalation des Arbeitsions Lithium angewendet. Es hat sich gezeigt, das das Überschußlithium vermutlich auf kristallographische Plätze mit der Wykoff-Bezeichnung 8b eingelagert wird. Zusätzlich wurden temperaturabhängige und sauerstoffpartialdruckabhängige Messungen an den Probenmaterialen durchgeführt, um Aussagen zum Stabilitätsbereich der Phase machen zu können.
Musical keys and chords recognition using unsupervised learning with infinite Gaussian mixture (2012)

This paper presents a Bayesian-based methodology that determines keys and chords of symbolic music using unsupervised learning guided by constraints. An infinite Gaussian mixture, a type of Dirichlet Process mixture, is constructed to model the generative processes of keys and chords. Keys and chords are recognized iteratively by generated key and chord samples using the same algorithm. The model only uses very simple profiles for keys and chords to guide the learning process without the use of training data or rules. The technique is also capable of recognizing key modulations. We demonstrate the performance of the proposed approach by comparing it against existing methods using 159 songs from the Beatles MIDI collection. The results show that the proposed method performs well in both keys and chords finding.
The Controlling Factors of the Natural Gas Hydrate Accumulation in the Songnan Low Uplift, Qiongdongnan Basin, China (2022)

Hydrocarbon charging stages and natural gas hydrate accumulation models were established in the Songnan Low Uplift, Qiongdongnan Basin (QDNB), China. Detailed geochemical analysis, paleotemperature and paleopressure analyses, seismic interpretation, and hydrocarbon charging characterization were conducted to investigate the controlling factors of natural gas hydrate accumulation. The Yacheng and Lingshui formations in the Lingshui Sag were identified as effective source rocks. The δ 13 C 1 values of the gas hydrates vary from −35.97‰ to −59.50‰, following a direction from the Sag Center to the Low Uplift, indicating that δ 13 C 1 values became relatively lighter during gas migration. Seismic data evidence revealed that large-scale faults, laterally distributed sandstones, and gas chimneys were comprehensive, however efficient hydrocarbon migration pathways. Systematic overpressure was developed in the Yacheng and Huangliu formations, which offer sufficient hydrocarbon migration impetus. Hydrocarbon-bearing aqueous inclusions and their coexisting aqueous inclusions were observed in the Huangliu Formation in the Lingshui Sag, indicating four stages of hydrocarbon charging in the QDNB. Based on the comprehensive analysis in this research, two gas hydrate accumulation models were proposed in the Songnan Low Uplift, QDNB, as follows: 1) a mixture of gas migrated by large-scale faults and a thermogenic-biogenic mixed gas model and 2) gas hydrates from laterally distributed sandstones sealed by MTDs.
Packaging design challenges of the IBM System z10 Enterprise Class server (2009)

This paper describes the system packaging and technologies of the IBM System z10™ high-end Enterprise Class server. This machine exceeds the multiprocessor performance of the previous system by 50%. A new generation of the IBM Elastic Interface was developed in order to maintain the increased interconnect signal speed of up to 2.93 Gb/s. Power control and power delivery to the multicore processors were a special challenge for the server packaging because of the high currents and the high number of voltage domains.
Identifying and Characterizing a Structural Domain of Protein Disulfide Isomerase (1996)

Protein disulfide isomerase (PDI) appears on the basis of its primary structure to be a multidomain protein, but the number and nature of the domains has been uncertain. Two of the domains, a and a', which are homologous to thioredoxin and active in catalysis of disulfide bond formation, have been identified and characterized previously. Sections of the N-terminal half of the PDI sequence have been expressed and the limits of their folded structures delineated by limited proteolysis. In addition to the a-domain, the boundaries of a domain with no activity on thiol/disulfide groups, designated b, have been identified. This domain has been produced independently; its cooperative unfolding transition and its CD and NMR spectra confirm that it is an autonomously folded structure in isolation and when part of PDI. Fusion of the b-domain to the a-domain, as occurs naturally in the first half of PDI, did not alter substantially the catalytic activity of the a-domain. It still catalyzes only a subset of the thiol/disulfide exchange reactions of intact PDI and has a reduced ability to catalyze protein disulfide rearrangements. The a- and b-domains account structurally for virtually all of the first half of the PDI polypeptide chain, and it is very unlikely that there exists a proposed third domain homologous to the estrogen receptor. The b-domain exhibits some sequence homology to calsequestrin, a calcium binding protein from the sarcoplasmic reticulum of muscle.
Berichtigung: A Potassium Diboryllithate: Synthesis, Bonding Properties, and the Deprotonation of Benzene (2020)

In reference [23] of this Communication, a wrong CCDC number (865529) is given for the structure of compound 2. The correct CCDC number is 1436491.
Particulate Interactions in Dry Powder Formulations for Inhalation (2001)

Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles established in surface and colloidal chemistry with pharmaceutical powder technology. It discusses some of the factors affecting particulate interactions, and particle-fluid interaction in the respiratory tract. It review some of the studies carried out in dry powder formulation development, and proposes possible strategies in improving DPI efficiency. The majority of these principles are applicable to other pharmaceutical solid dosage forms (e.g. tablets and capsules).
Hormone concentrations in tobacco roots change during arbuscular mycorrhizal colonization with Glomus intraradices* (2002)

• Phytohormones are known to play a pivotal role in various developmental processes in plants and in arbuscular-mycorrhizal (AM) fungal-host symbiosis. This study focuses on characterizing the changes in the concentrations of auxins, cytokinins and gibberellins in tobacco (Nicotiana tabacum) during the early stages of colonization by Glomus intraradices, using advanced analytical detection techniques. • High-pressure liquid chromatography analysis followed by radioimmunoassay detection revealed that AM colonization induced the accumulation of specific zeatin riboside-like and isopentenyl adenosine-like compounds in both roots and shoots. • Use of the gas chromatography-mass spectrometry technique on the same developmental stage revealed that gibberellins (GA) of the earl-13-hydroxylation biosynthetic pathway (GA<sub>1</sub> , GA<sub>8</sub> , GA<sub>19</sub> and GA<sub>20</sub> ) were significantly more abundant in roots, but not shoots, of AM inoculated plants than in those of nonmycorrhizal plants. Indoleacetic acid concentrations (total and free) remained unaltered by AM colonization. • This study demonstrates that hormonal changes do occur during AM symbiosis with tobacco, before the fungal benefits manifest.
Antipsychotic drug trifluoperazine as a potential therapeutic agent against nasopharyngeal carcinoma (2022)

The antipsychotic drug TFP could be a potential therapeutic regimen for NPC treatment.
Characterization of electrostatic gap-closing actuator arrays in aqueous conditions (2018)

We demonstrate high-force-density rapid actuation of electrostatic gap-closing actuator (GCA) arrays operating in an aqueous environment. These devices are designed to generate up to 4.6 mN at 6 V drive signal amplitudes and have measured pull-in times as fast as 121 μs with no electrolysis. We present a new model for the dynamics of aqueous GCA operation which includes the inertia of the squeezed fluid and proximity of the substrate to the device layer. The actuators operate in deionized water, and preliminary tests demonstrate actuation in ionic solutions (10 mM) and partial operation of submerged inchworm motors based on GCA arrays.
The splicing co-factor Barricade/Tat-SF1, is required for cell cycle and lineage progression inDrosophilaneural stem cells (2017)

Stem cells need to balance self-renewal and differentiation for correct tissue development and homeostasis. Defects in this balance can lead to developmental defects or tumor formation. In recent years, mRNA splicing has emerged as an important mechanism regulating cell fate decisions. Here we address the role of the evolutionarily conserved splicing co-factor Barricade (Barc)/Tat-SF1/CUS2 in <i>Drosophila</i> neural stem cell (neuroblast) lineage formation. We show that Barc is required for the generation of neurons during <i>Drosophila</i> brain development by ensuring correct neural progenitor proliferation and differentiation. Barc associates with components of the U2 small nuclear ribonucleoprotein (snRNP) complex, and its depletion causes alternative splicing in the form of intron retention in a subset of genes. Using bioinformatics analysis and a cell culture-based splicing assay, we found that Barc-dependent introns share three major traits: they are short, GC rich and have weak 3' splice sites. Our results show that Barc, together with the U2 snRNP complex, plays an important role in regulating neural stem cell lineage progression during brain development and facilitates correct splicing of a subset of introns.
Adolescent pre‐treatment with oxytocin protects against adult methamphetamine‐seeking behavior in female rats (2014)

The neuropeptide oxytocin (OT), given acutely, reduces self-administration of the psychostimulant drug methamphetamine (METH). Additionally, chronic OT administration to adolescent rats reduces levels of alcohol consumption in adulthood, suggesting developmental neuroplasticity in the OT system relevant to addiction-related behaviors. Here, we examined whether OT exposure during adolescence might subsequently inhibit METH self-administration in adulthood. Female Sprague-Dawley rats were administered vehicle or OT (1 mg/kg, i.p.) once daily from postnatal days (PND) 28 to 37 (adolescence). At PND 62 (adulthood), rats were trained to self-administer METH (intravenous, i.v.) in daily 2-hour sessions for 10 days under a fixed ratio 1 (FR1) reinforcement schedule, followed by determination of dose-response functions (0.01-0.3 mg/kg/infusion, i.v.) under both FR1 and progressive ratio (PR) schedules of reinforcement. Responding was then extinguished, and relapse to METH-seeking behavior assessed following priming doses of non-contingent METH (0.1-1 mg/kg, i.p.). Finally, plasma was collected to determine pre-treatment effects on OT and corticosterone levels. Results showed that OT pre-treatment did not significantly inhibit the acquisition of METH self-administration or FR1 responding. However, rats pre-treated with OT responded significantly less for METH under a PR reinforcement schedule, and showed reduced METH-primed reinstatement with the 1 mg/kg prime. Plasma OT levels were also significantly higher in OT pre-treated rats. These results confirm earlier observations that adolescent OT exposure can subtly, yet significantly, inhibit addiction-relevant behaviors in adulthood.
Introduction of hepatitis delta virus into animal cell lines via cationic liposomes (1994)

Cationic liposomes are known to facilitate efficient transfection of animal cells with DNA and even some viruses. As reported here, we have been able to use such a commercially available formulation (Lipofectamine) and introduce human hepatitis delta virus (HDV) into lines of cultured cells and demonstrate replication of the HDV genome both by immunofluorescence and by Northern (RNA) analysis. As much as 10% of the human hepatoma cell line Huh7 was transfected with HDV. Also transfected were the baby hamster kidney cell line BHK-21 and the Morris rat hepatoma line 7777. Two initial applications of HDV transfection have been made. (i) The ribonucleoprotein structure of HDV was isolated from disrupted virions and demonstrated as being sufficient to transfect Huh7 cells. In contrast, naked HDV RNA was not sufficient. (ii) From a study of cells transfected with HDV particles, it was found that, even after as long as 7 weeks and the associated replication of the transfected cells, the HDV RNA genome was still replicating. Apparently, HDV, in the absence of helper virus and in the absence of virus assembly, can maintain persistent replication and expression of the HDV genome. Transfection was also achieved with woodchuck hepatitis virus introduced into Huh7 cells. In summary, this transfection procedure should be of use for the study of these and maybe other recalcitrant animal viruses.
Maitotilojen tuotannonohjauksen ja seurannan kehittämisprojekti. Loppuraportti 1.1.1999-31.3.2001 (2013)

Nimekkeen selvennys: The use of individual test day information in dairy herd management Final report 1.1.1999-31.3.2001.
System control structure of the IBM eServer z900 (2002)

As computer systems become more complex, the use of embedded controllers for initializing and maintaining system operation is becoming increasingly prevalent. In the IBM eServer z900, a new control approach was introduced. This paper discusses why its introduction was necessary and outlines its associated, key technological and economic innovations. In particular, the following topics are addressed: service subsystem topology, hardware elements for performing system control, hardware abstraction, object-oriented framework for control, and inter-networking of system control microprocessors.
Hot hole transport and noise phenomena in silicon at cryogenic temperatures from first principles (2023)

The transport properties of hot holes in silicon at cryogenic temperatures exhibit several anomalous features, including the emergence of two distinct saturated drift velocity regimes and a non-monotonic trend of the current noise versus electric field at microwave frequencies. Despite prior investigations, these features lack generally accepted explanations. Here, we examine the microscopic origin of these phenomena by extending a recently developed ab-initio theory of high-field transport and noise in semiconductors. We find that the drift velocity anomaly may be attributed to scattering dominated by acoustic phonon emission, leading to an additional regime of drift velocity saturation at temperatures $\sim 40$ K for which the acoustic phonon occupation is negligible; while the non-monotonic trend in the current noise arises due to the decrease in momentum relaxation time with electric field. The former conclusion is consistent with the findings of prior work, but the latter distinctly differs from previous explanations. This work highlights the use of high-field transport and noise phenomena as sensitive probes of microscopic charge transport phenomena in semiconductors.
A discrete time controller for a single stage three level resonant PFC converter operated with variable frequency phase shift modulation (2007)

This paper presents a discrete time cycle by cycle controller for a three level resonant single stage power factor correction converter. The controller is supposed to generate variable frequency phase shift modulated (VFPSM) gate signals to the switches. The merits of such control method is to tightly regulate the output voltage, shape the input ac current as well as regulating the dc bus voltage to a specified value throughout the operation range of the converter. The output voltage control loop determines the required switching frequency for the resonant converter to regulate the output voltage, whereas the pulse width is determined by the dc-bus voltage control loop. The sampling period for the controller is determined by the switching frequency obtained from the output voltage control loop. This converter provides high efficiency, reduced voltage stresses, universal input voltage capability, input/output isolation, simplicity of controller implementation and most importantly increased power density. The proposed method is verified through a 2.3 kW, 48 V three level, single stage LCC converter with input voltage varying from 90-265 V rms.
Comparison of the effects of the intestinal permeation enhancers, SNAC and sodium caprate (C10): Isolated rat intestinal mucosae and sacs (2020)

SNAC and C10 are intestinal permeation enhancers (PEs) used in formulations of peptides for oral delivery in clinical trials. Our aims were to compare their: (i) mechanism of action in isolated rat intestinal mucosae mounted in Ussing chambers and in non-everted gut sacs, (ii) effects on mucosa integrity in those models and also in in situ intra-jejunal instillations and (iii) interactions with intestinal mucus. SNAC increased the apparent permeability coefficient (Papp) of the paracellular marker, FITC-dextran 4000 (FD4), across isolated rat gastric mucosae in concentration-dependent fashion, whereas C10 did not, while both reduced the transepithelial electrical resistance (TEER). In isolated jejunal and colonic mucosae, both agents increased the Papp of [14C]-mannitol and FD4 whereas C10 but not SNAC reduced TEER. 20 mM SNAC was required to achieve the efficacy of 10 mM C10 in jejunal and colonic mucosae. In isolated non-everted jejunal and colonics sacs, FD4 flux increases were observed in the presence of both PEs. Histology of mucosae revealed that both PEs induced minor epithelial damage to the mucosa at concentrations that increased fluxes. Jejunal tissue withstood epithelial damage in the following order: intra jejunal in situ instillations > jejunal sacs > isolated jejunal mucosae. Both PEs modulated viscoelastic properties of porcine jejunal mucus without altering rheological properties. In conclusion, SNAC and C10 are reasonably efficacious PEs in rat intestinal tissue with common overall mechanistic features. Their potency and toxic potential are low, in agreement with clinical trial data.
Identificação de falantes : aspectos teoricos e metodologicos (1994)

Orientador: Eleonora Albano
The Treatment of Cancer: A Comprehensive Therapeutic Model Entailing a Complex of Interaction Modalities (2013)

The Treatment of Cancer: A Comprehensive Therapeutic Model Entailing a Complex of Interaction Modalities
CLUSTER STATES IN 12C AND 14C (2010)

The cluster structure of 12 C is explored and recent measurements of proton inelastic scattering, suggesting a 2 + state close to 9.6 MeV are presented. Resonant scattering studies of 10 Be + 4 He used to populate resonances in 14 C are briefly discussed.
Synthesis, spectroscopic properties, and chemistry of 4,6-diphenyl-2-pyridones and 4,6-diphenylpyridine-2-thiones and their relationship to isomeric species (1977)

4,6-Diphenylpyran-2-imines (9) are rearranged by sodium ethoxide to the isomeric 2-pyridones (10), but the corresponding thiopyran-2-imines (21) do not rearrange to pyridine-2-thiones (25). The conversion (10)→(25) is effected by phosphorus pentasulphide. Certain pyridine-2-thiones (25) rearrange to 2-arylthiopyridines (27) on heating. The isomeric compounds are readily distinguished by their mass spectra; n.m.r., u.v., and i.r. spectra are discussed.
The Content Manager: a tool to develop multilingual and multi-preference Web sites (2001)

The authors outline their experience in developing a multilingual and multiple preference Web site. In particular we describe Content Manager, a tool we developed to support the implementation of a business to consumer (B2C) international Web site. We also describe the business requirements and challenges that we encountered. There are many commercial tools for managing a Web site's content, but these tools are unable to manage the complexity of diverse languages' taxation frameworks, and cultural systems. We found that by separating the content from the source code (as supposed to embedding text within the Web page), we were able to focus on the development of the Web site instead of worrying about the differences between target countries. Content Manager allowed us to maintain this separation and eased the development process.
Synthesis and characterization of electrically conductive polyethylene-supported graphene films (2014)

72.80.Vp; 78.67.Wj; 78.66.Qn; 85.40.Hp.