gebhart/patrepeval huggingface dataset:
Non-invasive muscle biopsy: estimation of muscle fibre size from a neuromuscular interface (2022)

ABSTRACT Because of the biophysical relation between muscle fibre diameter and the propagation velocity of action potentials along the muscle fibres, motor unit conduction velocity (MUCV) could be a non-invasive index of muscle fibre size in humans. However, the relation between MUCV and fibre size has been only assessed indirectly in animal models and in human patients with invasive intramuscular EMG recordings, or it has been mathematically derived from computer simulations. By combining advanced non-invasive techniques to record motor unit activity in vivo, i.e., high-density surface EMG, with the gold standard technique for muscle tissue sampling, i.e., muscle biopsy, here we investigated the relation between the conduction velocity of populations of motor units identified from the biceps brachii muscle, and muscle fibre diameter. Moreover, we demonstrate the possibility to predict muscle fibre diameter (R 2 = 0.66) and cross-sectional area (R 2 = 0.65) from conduction velocity estimates with low systematic bias (~2% and ~4% respectively) and a relatively low margin of individual error (~8% and ~16%, respectively). The proposed neuromuscular interface opens new perspectives in the use of high-density EMG as a non-invasive tool to estimate muscle fibre size without the need of surgical biopsy sampling. The non-invasive nature of high-density surface EMG for the assessment of muscle fibre size may be useful in studies monitoring child development, aging, space and exercise physiology. SIGNIFICANCE STATEMENT Our study explored the relation between the conduction velocity of populations of motor units and muscle fibre size in healthy humans. Our results provide in vivo evidence that a high-density surface EMG-derived physiological parameter, i.e. motor unit conduction velocity, can be adopted to estimate muscle fibre size, without the need of surgical biopsy sampling. Here we propose a neuromuscular interface that opens new perspectives not only in the study of neuromuscular disorders, but also in other fields where the non-invasive and painless determination of muscle fibre and motor unit size becomes a priority, such as in aging, space and exercise physiology.
The Acquired Immunodeficiency Syndrome (1986)

"The Acquired Immunodeficiency Syndrome." American Review of Respiratory Disease, 134(5), pp. 859–861
A new evolutionary channel for Type Ia supernovae (2003)

We show that long-period dwarf novae offer a promising route for making Type Ia supernovae. For typical dwarf nova duty cycles d ~ 0.1 - 0.01, mass is accreted by the white dwarf mainly during dwarf nova outbursts at rates allowing steady nuclear burning of most of the accreted matter. Mass gains up to ~ 0.4 Msun are possible in this way. Although these are too small to allow a 0.7 Msun WD to reach the Chandrasekhar mass, they are sufficient if the WD grew to ~ 1 Msun in a previous episode of thermal-timescale mass transfer, i.e. for those long-period dwarf novae which descend from supersoft binaries. A further advantage of this picture is that the supernova always occurs in a binary of small secondary/primary mass ratio, with the secondary having very little remaining hydrogen. Both features greatly reduce the possibility of hydrogen contamination of the supernova ejecta.
Swimming In a Crystal (2014)

We study catalytic Janus particles and Escherichia coli bacteria swimming in a two-dimensional colloidal crystal. The Janus particles orbit individual colloids and hop between colloids stochastically, with a hopping rate that varies inversely with fuel (hydrogen peroxide) concentration. At high fuel concentration, these orbits are stable for 100s of revolutions, and the orbital speed oscillates periodically as a result of hydrodynamic, and possibly also phoretic, interactions between the swimmer and the six neighbouring colloids. Motile E. coli bacteria behave very differently in the same colloidal crystal: their circular orbits on plain glass are rectified into long, straight runs, because the bacteria are unable to turn corners inside the crystal.
Pigment Epithelium-Derived Factor Secreted from Retinal Pigment Epithelium Facilitates Apoptotic Cell Death of iPSC (2013)

We show that pigment epithelium-derived factor (PEDF), which is secreted from primary or iPSC-derived retinal pigment epithelium (RPE), dramatically inhibits the growth of iPSCs. PEDF is detected abundantly in culture supernatants of primary or iPSC-derived RPE. Apoptotic cell death is induced in iPSC when co-cultured with RPE, a process that is significantly blocked by addition of antibody against PEDF. Indeed, addition of recombinant PEDF to the iPSC cell culture induces apoptotic cell death in iPSCs, but the expression of pluripotency related-genes is maintained, suggesting that PEDF causes cell death, not differentiation, of iPSCs. To recapitulate this event in vivo, we examined tumor formation in NOG mice after subcutaneous injection of iPSCs with or without an iPSC-derived RPE sheet (2.5 × 10(5) RPE cells). We observed that the tumor forming potential of iPSCs was significantly suppressed by simultaneous transplantation with an iPSC-derived RPE sheet.
Multiple E2F-Induced MicroRNAs Prevent Replicative Stress in Response to Mitogenic Signaling (2010)

Transcription of microRNAs (miRNAs) is thought to be regulated similarly to that of protein-coding genes. However, how miRNAs are regulated during the cell division cycle is not well understood. We have analyzed the transcription profiles of miRNAs in response to mitogenic stimulation in primary fibroblasts. About 33% of the miRNAs expressed in these cells are induced upon exit from quiescence. Many of these miRNAs are specifically induced by E2F1 or E2F3 during the G(1)/S transition and are repressed in E2F1/3-knockout cells. At least four miRNA clusters, let-7a-d, let-7i, mir-15b-16-2, and mir-106b-25, are direct targets of E2F1 and E2F3 during G(1)/S and are repressed in E2F1/3-null cells. Interestingly, these miRNAs do not contribute to E2F-dependent entry into S phase but rather inhibit the G(1)/S transition by targeting multiple cell cycle regulators and E2F targets. In fact, E2F1 expression results in a significant increase in S-phase entry and DNA damage in the absence of these microRNAs. Thus, E2F-induced miRNAs contribute to limiting the cellular responses to E2F activation, thus preventing replicative stress. Given the known function of E2F of inducing other oncogenic miRNAs, control of miRNAs by E2F is likely to play multiple roles in cell proliferation and in proliferative diseases such as cancer.
Fabrication and optimization of alginate hydrogel constructs for use in 3D neural cell culture (2011)

Two-dimensional (2D) culture systems provide useful information about many biological processes. However, some applications including tissue engineering, drug transport studies, and analysis of cell growth and dynamics are better studied using three-dimensional (3D) culture systems. 3D culture systems can potentially offer higher degrees of organization and control of cell growth environments, more physiologically relevant diffusion characteristics, and permit the formation of more extensive 3D networks of cell-cell interactions. A 3D culture system has been developed using alginate as a cell scaffold, capable of maintaining the viability and function of a variety of neural cell types. Alginate was functionalized by the covalent attachment of a variety of whole proteins and peptide epitopes selected to provide sites for cell attachment. Alginate constructs were used to entrap a variety of neural cell types including astroglioma cells, astrocytes, microglia and neurons. Neural cells displayed process outgrowth over time in culture. Cell-seeded scaffolds were characterized in terms of their biochemical and biomechanical properties, effects on seeded neural cells, and suitability for use as 3D neural cell culture models.
Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry (2013)

The interdependence of p53 and MDM2 is critical for proper cell survival and cell death and, when altered, can lead to tumorigenesis. Mitogen-activated protein kinase (MAPK) signaling pathways function in a wide variety of cellular processes, including cell growth, migration, differentiation, and death. Here we discovered that transforming growth factor β-activated kinase 1 (TAK1)-binding protein 1 (TAB1), an activator of TAK1 and of p38α, associates with and inhibits the E3 ligase activity of MDM2 toward p53 and its homolog, MDMX. Depletion of TAB1 inhibits MDM2 siRNA-mediated p53 accumulation and p21 induction, partially rescuing cell cycle arrest induced by MDM2 ablation. Interestingly, of several agents commonly used as DNA-damaging therapeutics, only cell death caused by cisplatin is mitigated by knockdown of TAB1. Two mechanisms are required for TAB1 to regulate apoptosis in cisplatin-treated cells. First, p38α is activated by TAB1 to phosphorylate p53 N-terminal sites, leading to selective induction of p53 targets such as NOXA. Second, MDMX is stabilized in a TAB1-dependent manner and is required for cell death after cisplatin treatment. Interestingly TAB1 levels are relatively low in cisplatin-resistant clones of ovarian cells and in ovarian patient's tumors compared with normal ovarian tissue. Together, our results indicate that TAB1 is a potential tumor suppressor that serves as a functional link between p53-MDM2 circuitry and a key MAPK signaling pathway.
Hello neighbor: Accurate object retrieval with k-reciprocal nearest neighbors (2011)

This paper introduces a simple yet effective method to improve visual word based image retrieval. Our method is based on an analysis of the k-reciprocal nearest neighbor structure in the image space. At query time the information obtained from this process is used to treat different parts of the ranked retrieval list with different distance measures. This leads effectively to a re-ranking of retrieved images. As we will show, this has two benefits: first, using different similarity measures for different parts of the ranked list allows for compensation of the “curse of dimensionality”. Second, it allows for dealing with the uneven distribution of images in the data space. Dealing with both challenges has very beneficial effect on retrieval accuracy. Furthermore, a major part of the process happens offline, so it does not affect speed at retrieval time. Finally, the method operates on the bag-of-words level only, thus it could be combined with any additional measures on e.g. either descriptor level or feature geometry making room for further improvement. We evaluate our approach on common object retrieval benchmarks and demonstrate a significant improvement over standard bag-of-words retrieval.
Performance Reassessment of a Real‐time Seizure‐detection Algorithm on Long ECoG Series (2002)

The generic algorithm demonstrated high sensitivity, specificity, and speed, characteristics further enhanced by adaptation. This algorithm is well suited for seizure detection/warning and use in safety/efficacy closed-loop therapy studies.
Caracterización de la durabilidad de los hormigones de polvo reactivo (HPR) con fibras metálicas y sin fibras (2002)

La utilizaci&amp;oacute;n de aditivos reductores de agua y la incorporaci&amp;oacute;n de part&amp;iacute;culas ultra finas en los hormigones, han permitido mejorar considerablemente su rendimiento mec&amp;aacute;nico as&amp;iacute; como su durabilidad. La reducci&amp;oacute;n de la porosidad se traduce en una gran resistencia de los hormigones frente a la penetraci&amp;oacute;n de agentes agresivos.\n\n\t\t\t\t En este trabajo la durabilidad de los Hormigones de Polvo Reactivo (HPR) se compara con la de dos hormigones de referencia H-30 y H-80. El HPR presenta una resistencia muy buena frente a la carbonataci&amp;oacute;n, a la penetraci&amp;oacute;n de iones cloruro, a la abrasi&amp;oacute;n y a los ciclos de hielo-deshielo. El estudio de la cin&amp;eacute;tica de la corrosi&amp;oacute;n de las armaduras met&amp;aacute;licas en el HPR se ha realizado por v&amp;iacute;a electroqu&amp;iacute;mica. Las medidas experimentales asociadas a c&amp;aacute;lculos de predicci&amp;oacute;n permiten establecer las velocidades de penetraci&amp;oacute;n de los agresivos estudiados y dimensionar el recubrimiento m&amp;iacute;nimo de las armaduras pretensadas que se deben utilizar.
Corporate Strategies for the 21st Century With Special Emphasis on Global Marketing Strategies (1998)

A-2 Nowdays, the world economic system is dominated by two major organizing forces : globalization and regionalization. Globalization forces are stirring significant change throughout the world and creating a new world economic order as the world approaches the 21st century. Development in transportation and telecommunications along with easy access to information has transformed the world into a global community. This transformation has been accelerated by a series of dramatic political changes, the implementation of more open policies toward trade and investment, and a substantial expansion in crossborder interactions involving the movements of capital, technology, culture as well as personnel.
Abstract 5378: SB225002 induces apoptosis in acute lymphoid leukemia cells (2011)

Abstract Acute Lymphoblastic Leukemia (ALL) is the most frequent childhood malignancy. We have recently shown that the leukemic bone marrow (BM) contains high levels of interleukin-8 (IL-8), whose cognate receptor CXCR2 is expressed by most primary ALL cells. ALL cell lines are sensitive to SB225002 (N-(2-hydroxy-4-nitrophenyl)-N’-(2-bromophenyl)urea), a CXCR2 antagonist. Surprisingly, the inhibitory effect of this drug was found to be independent of CXCR2 expression by leukemic cells. The current study was conducted to determine the mechanism of action of SB225002 against ALL cells, using as prototype the T-ALL cell line Jurkat. Cell cycle analysis showed that SB225002 induces G2-M cell cycle arrest. Transcriptional profiling by microarray analysis revealed that SB225002 induces 174 genes and represses 41 genes. SB225002 induced-apoptosis triggered a transcriptional program of genes involved in activation of the JUN and p53 pathways and inhibition of the TNFα pathway. Results were further confirmed by Q-PCR and/or Western blot analysis. Treatment of Jurkat cells with SB225002 also induced the activation of phospho-p44/42 MAPK (ERK1/2), which was suspected to be an anti-apoptotic pathway triggered by injured cells. In fact, the inhibition of ERK1/2 with pharmacologic inhibitors, in combination with SB225002, resulted in the enhancement of apoptosis, suggesting the blockage of ERK1/2 pathway as a strategy to increase the sensitivity of ALL cells toward SB225002. Connectivity Map analysis of the SB225002 gene signature demonstrates a positive correlation with the signatures for PI3K and HSP90 inhibitors (connectivity score 1 and 0.944, respectively), which mediate apoptosis through effects on AKT, TNFα and NF-κB, while SB225002's mediated-apoptosis demonstrated only to inhibit TNFα pathway. Furthermore, SB225002 gene signature demonstrates a positive correlation with Nocodazole and Podophyllotoxin (connectivity score 0.895 and 0.859, respectively), which are inducers of cancer cell apoptosis by interfering with microtubule polymerization and inhibiting topoisomerase II, respectively. Our data demonstrate for the first time that JUN, p53, and TNFα pathways are modulated by SB225002, and that ALL cells are sensitized to SB225002-induced apoptosis after phospho-p44/42 MAPK inhibition. Overall these data support SB225002's therapeutic potential in ALL. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5378. doi:10.1158/1538-7445.AM2011-5378
On clinical validation of Fly-Over visualization technique for virtual colonoscopy (2009)

In this paper, we aim to provide the further evaluation on the recently proposed visualization technique known as Virtual Fly-Over for virtual colonoscopy by using clinical CT colonography datasets. The proposed method mainly consists of two steps: splitting the entire colon anatomy into exactly two halves, and assigning a virtual camera to each half to perform fly-over navigation. We have quantitatively validated the effectiveness of the proposed technique by using 22 real CT colonography datasets. Experimental results have shown that the average surface visibility coverage is 97.49±1.02%.
Pulmonary Hemodynamic Effects of Antisheep Serum-Induced Leukopenia (1986)

Antisheep antileukocyte serum (ALS) was produced in rabbits, purified, and adsorbed against erythrocytes and platelets. The ALS was infused intra-arterially over a 3-hour period into anesthetized sheep (n = 6) prepared with lung lymph fistulas. Pulmonary vascular resistance (PVR) and pulmonary lymph flow (Qlym) increased two- to threefold while the lymph-to-plasma protein concentration ratio (L/P) did not change from baseline, suggesting an increase in pulmonary vascular permeability to proteins. The arterial leukocyte count decreased from 4,935 +/- 840 to 1,385 +/- 325 cells/microliters, the neutrophil count decreased from 1,045 +/- 265 to 340 +/- 130 cells/microliters, and the platelet count decreased from 2.8 X 10(5) +/- 0.2 X 10(5) to 0.65 X 10(5) +/- 0.12 X 10(5) cells/microliters. ALS induced neutrophil aggregation in vitro, but not platelet aggregation. In the present study, we also examined the effects of ALS-induced leukopenia on the increase in pulmonary vascular permeability after intravenous alpha-thrombin challenge to assess the role of leukocytes in mediating the increased permeability response. Sheep (n = 5) were made leukopenic by an intramuscular injection of ALS; Qlym was in the normal range 4 to 5 hours after the ALS administration. In the leukopenic group, thrombin challenge caused an increase in Qlym from 7.8 +/- 0.7 to 12.9 +/- 1.9 ml/hr (a 64% increase) while L/P decreased from 0.86 +/- 0.04 to 0.70 +/- 0.05 (a 19% decrease). In contrast, thrombin-induced intravascular coagulation in control sheep (n = 5) produced a 250% increase in Qlym with an increase in L/P. The results indicate that leukocytes are required for the increase in lung vascular permeability after thrombin-induced intravascular coagulation.
Research data supporting Is low phosphorus content in steel a product requirement? (2017)

The data consists of images and excel spreadsheets used to create the publication on the concentration of phosphorus that would be tolerable given certain characteristics of steels.
Location Explorer with information services: A mobile application to deliver location-based web services (2013)

In this paper, we propose an approach to delivering location-based information (LBI) and location-based web services (LBWS) to users based on users' past behaviors. The service usage patterns mined from the user's historical location visiting records and service utilization records are used to suggest relevant LBI and LBWS. Furthermore, the social network services are also adopted to enhance the usability of recommendation functions. For illustrating the feasibility of the proposed approach, a software system, called Location Explorer with Information Services (Lewis), is designed and implemented to realize the features of personalized location-based service delivery and web service utilization.
A 1 GHz AGC amplifier in BiCMOS with 3 μs settling-time for 802.11a WLAN (2005)

An analog automatic gain control (AGC) amplifier for application in an 802. I la transceiver with a settling time of 3 μ s within ± I dB limits has been designed and tested. The amplifier operates up to 1.2 GHz and has a linear-in-dB gain control with 63 dB maximum gain, and an AGC range of 45 dB. The AGC detects the averaged signal strength. The circuit includes a fill-wave rectifier and a rail-to-rail difference amplifier. It is fabricated in a 0.25 μm SiCe:C BiCMOS process.
Efficacy, Safety, and Biomarkers of Single-Agent Bevacizumab Therapy in Patients with Advanced Hepatocellular Carcinoma (2012)

Bevacizumab is active and well tolerated in patients with advanced HCC. The clinical value of CECs, IL-6, and IL-8 warrants further investigation.
Outcomes after induction chemotherapy in patients with acute myeloid leukemia arising from myelodysplastic syndrome (2010)

Prior treatment with hypomethylating agents or lenalidomide, poor risk cytogenetics, and longer time to transformation to AML are independent negative predictive factors for response and OS in patients with secondary AML after induction therapy.
Measurements of the complex permittivity of microwave circuit board substrates using split dielectric resonator and reentrant cavity techniques (1996)

The split dielectric resonator technique makes it possible to measure the real part of permittivity of isotropic materials for a very broad permittivity range and dielectric loss tangents in the range from 10⁻⁴ to 10⁻¹ with high accuracy. For uniaxially anisotropic materials, the split resonator method permits measurement of the permittivity and and the dielectric loss tangent in the plane parallel to the the sample bottoms. Additional measurements using re-entrant cavity enable determination of permittivity and the dielectric loss tangent perpendicular to this plane.
Penetrating Radiation Systems and Applications III (2001)

v Conference Committee SESSION 1 BIOMEDICAL APPLICATIONS I 7080 02 Ultrashort relativistic electron bunches and spatio-temporal radiation biology (Invited Paper) [7080-01] Y. A. Gauduel, J. Faure, V. Malka, Ecole Polytechnique - ENS Techniques Avancees (France) 7080 03 Novel embossed radiography system utilizing energy subtraction [7080-02] A. Osawa, Toho Univ. School of Medicine (Japan); E. Sato, Iwate Medical Univ. (Japan); H. Matsukiyo, T. Enomoto, M. Watanabe, J. Nagao, Toho Univ. School of Medicine (Japan); P. Abderyim, Iwate Univ. (Japan); E. Tanaka, Tokyo Univ. of Agriculture and Technology (Japan); M. Izumisawa, A. Ogawa, S. Sato, Iwate Medical Univ. (Japan) 7080 06 Developing three-dimensional display technologies [7080-05] W. J. Dallas, H. Roehrig, Univ. of Arizona (United States); D. J. Allen, Southern Arizona VA Health Care System (United States) 7080 07 X-ray fluorescence camera for biomedical imaging [7080-06] H. Matsukiyo, Toho Univ. School of Medicine (Japan); E. Sato, Iwate Medical Univ. (Japan); P. Abderyim, Iwate Univ. (Japan); A. Osawa, T. Enomoto, M. Watanabe, J. Nagao, Toho Univ. School of Medicine (Japan); S. Nomiya, Raytec Inc. (Japan); K. Sato, Toreck Inc. (Japan); A. Ogawa, S. Sato, Iwate Medical Univ. (Japan); T. Ichimaru, Hirosaki Univ. (Japan) SESSION 2 BIOMEDICAL APPLICATIONS II 7080 09 A mammography imaging hybrid pixel sensor test chip with low-noise CMOS readout IC on fully depleted silicon-on-insulator design [7080-08] D. Nguyen, H. Cormican, A. Baysal, C. Wiswall, T. Kerr, Bioptics Inc. (United States); J. M. Wang, D. Ma, Univ. of Arizona (United States) 7080 0A X-ray fluorescence computed tomography system for biomedical imaging [7080-09] T. Enomoto, Toho Univ. School of Medicine (Japan); E. Sato, Iwate Medical Univ. (Japan); P. Abderyim, Iwate Univ. (Japan); H. Matsukiyo, A. Osawa, M. Watanabe, J. Nagao, Toho Univ. School of Medicine (Japan); S. Nomiya, Raytec Inc. (Japan); K. Hitomi, Tohoku Institute of Technology (Japan); M. Izumisawa, A. Ogawa, S. Sato, Iwate Medical Univ. (Japan) 7080 0B Energy-discriminating K-edge x-ray computed tomography system [7080-10] M. Watanabe, Toho Univ. School of Medicine (Japan); E. Sato, Iwate Medical Univ. (Japan); P. Abderyim, Iwate Univ. (Japan); H. Matsukiyo, A. Osawa, T. Enomoto, J. Nagao, Toho Univ. School of Medicine (Japan); S. Nomiya, Raytec Inc. (Japan); K. Hitomi, Tohoku Institute of Technology (Japan); A. Ogawa, S. Sato, Iwate Medical Univ. (Japan); T. Ichimaru, Hirosaki Univ. (Japan)