gebhart/patrepeval huggingface dataset:
Enantioselective total syntheses of Teubrevin G and Teubrevin H and studies toward the Enantioselective Total Synthesis of Vinigrol / (2001)

Total syntheses o f teubrevin G and teubrevin H are described.The successflil approach to these novel diterpenoids involves a highly regiocontrolled [4+2] cycloaddition-fragmentation sequence as a novel and possibly general method to assemble functionalized monocyclic furans.Medium-sized ring construction was accomplished by efficient ring-closing olefin metathesis.Utilization o f a new generation ruthenium catalyst was shown to be crucial for the success o f this transformation.Two o f three stereogenic centers were assembled independently by asymmetric processes.The chirality merger event occurred with good diastereocontrol that appears to be intimately associated w ith the conformational properties o f the (3keto ester enolate coupling partner.The synthetic strategy em ployed emphasizes convergence and serves as a test for new synthetic methodologies in heterocyclic and m edium-sized ring arenas.In a com panion study, different cyclization methods were investigated with an objective to complete construction o f the carbon skeleton o f vinigrol, a novel diterpenoid with a unique structure.Direct connection o f two side arms using decalin fragment as a tem plate was examined initially.Different cyclization methods including nucleophile addition to a carbonyl group, ring-closing metathesis, and M cM urry coupling were scrutinized.Formation o f a bigger ring with a ring contraction to follow was examined as well.Effects o f substituents on the decalin core were employed as a tool to influence the conformational mobility o f the template.The acciunulated data suggest that conformational constraints imposed on the system m ight facilitate the desired carbon-carbon bond formation.Accordingly, the sixmembered ring lactones 193 and 218 were synthesized and their reactivity was investigated.Attempts to prepare the seven-membered ring lactones 191 and 200 were unsuccessful.A considerable amount o f knowledge was accumulated that should help to advance further studies in this area.Dedicated to two women who make my life worth living -my wife Julia and my mother.
Subaru Telescope adaptive optics observations of gravitationally lensed quasars in the Sloan Digital Sky Survey (2016)

We present the results of an imaging observation campaign conducted with the Subaru Telescope adaptive optics system (IRCS+AO188) on 28 gravitationally lensed quasars and candidates (23 doubles, 1 quad, 1 possible triple, and 3 candidates) from the SDSS Quasar Lens Search. We develop a novel modelling technique that fits analytical and hybrid point spread functions (PSFs), while simultaneously measuring the relative astrometry, photometry, as well as the lens galaxy morphology. We account for systematics by simulating the observed systems using separately observed PSF stars. The measured relative astrometry is comparable with that typically achieved with the &lt;it&gt;Hubble Space Telescope&lt;/it&gt;, even after marginalizing over the PSF uncertainty. We model for the first time the quasar host galaxies in five systems, without a priori knowledge of the PSF, and show that their luminosities follow the known correlation with the mass of the supermassive black hole. For each system, we obtain mass models far more accurate than those previously published from low-resolution data, and we show that in our sample of lensing galaxies the observed light profile is more elliptical than the mass, for ellipticity &amp;gsim;0.25. We also identify eight doubles for which the sources of external and internal shear are more reliably separated, and should therefore be prioritized in monitoring campaigns aimed at measuring time delays in order to infer the Hubble constant.
Loop Gain Calculation With Spice (2010)

Efficient implementation of R. David Middlebrook's General Feedback Theorem in a circuit simulator like SPICE.
Insecticide Control of Sweetpotato Whitefly on Broccoli and Lettuce, 1992 (1994)

Abstract The studies were conducted at the USDA-ARS Irrigated Desert Research Station at Brawley, CA in randomized complete blocks design with four replicates. Hybrid broccoli, cv. ‘Packman’ at 7.6 seeds/ft seed row, and head lettuce, cv. ‘Empire MI’ at 8.5 seeds/ft seed row, each in separate plots, were planted on 25 Sep. Plots of each crop were two rows (beds) in 40-inch row spacing and 20 ft long. Seed rows of each crop were spaced 20 inches apart on a bed. Plots were separated by two fallow rows and blocks separated by 20-ft fallow alleys. Treatments were (1) untreated, (2) weekly foliar application of Capture 0.08 lb Al/acre and Monitor 0.75 lb Al/acre, (3) weekly foliar application of mixture of Danitol 0.2 lb Al/acre and Monitor 0.75 lb Al/acre, (4) soil application of Admire 0.345 lb Al/acre at planting, (5) treatment 4 plus foliar application once of Admire 0.345 lb Al/acre 3 weeks after planting, (6) treatment 4 plus foliar application once of Admire 0.345 lb Al/acre 4 weeks after planting, (7) treatment 4 plus weekly foliar application of treatment 2 beginning on week 4 after planting, (8) treatment 4 plus weekly foliar application of treatment 3 beginning on week 4 after planting, (9) weekly foliar application of CGA 245704 0.044 lb Al/acre. Weekly foliar applications of treatments 2, 3 and 9 were initiated on 7 Oct (7 days after plant emergence or 12 days after planting). A total of seven applications was made. Foliar applications of treatments 5 and 6 were made on 14 and 21 Oct, respectively. Five weekly applications of treatment 7 and 8 were made beginning on 21 Oct. Treatments were applied with a backpack sprayer to deliver 29 gal/acre. SPWF immatures were counted on each side of a leaf disk of 3.14 cm2 taken from each fourth leaf from plant terminals. Pretreatment counts were made on leaf discs from ten leaves on 6 Oct, 1 day before the first treatments were applied. Thereafter weekly leaf samples were taken 6 days after each application and 1 day before the next application. The last samples were taken on 29 Dec. Crops were harvested three times on 4, 11 and 18 Jan 1993.
Sensor Thermal Barrier Coatings: Remote In Situ Condition Monitoring of EB-PVD Coatings at Elevated Temperatures (2009)

Thermal barrier coatings (TBCs) are used to reduce the actual working temperature of the high pressure turbine blade metal surface. Knowing the temperature of the surface of the TBC and at the interface between the bondcoat and the thermally grown oxide (TGO) under realistic conditions is highly desirable. As the major life-controlling factors for TBC systems are thermally activated, therefore linked with temperature, this would provide useful data for a better understanding of these phenomena and to assess the remaining lifetime of the TBC. This knowledge could also enable the design of advanced cooling strategies in the most efficient way using minimum amount of air. The integration of an on-line temperature detection system would enable the full potential of TBCs to be realized due to improved precision in temperature measurement and early warning of degradation. This, in turn, will increase fuel efficiency and reduce CO2 emissions. The concept of a thermal-sensing TBC was first introduced by Choy, Feist, and Heyes (1998, “Thermal Barrier Coating With Thermoluminescent Indicator Material Embedded Therein,” U.S. Patent U.S. 6974641 (B1)). The TBC is locally modified so it acts as a thermographic phosphor. Phosphors are an innovative way of remotely measuring temperatures and also other physical properties at different depths in the coating using photo stimulated phosphorescence (Allison and Gillies, 1997, “Remote Thermometry With Thermographic Phosphors: Instrumentation and Applications,” Rev. Sci. Instrum., 68(7), pp. 2615–2650). In this study the temperature dependence of several rare earth doped EB-PVD coatings will be compared. Details of the measurements, the influence of aging, the composition, and the fabrication of the sensing TBC will be discussed in this paper. The coatings proved to be stable and have shown excellent luminescence properties. Temperature detection at ultrahigh temperatures above 1300°C is presented using new types of EB-PVD TBC ceramic compositions. Multilayer sensing TBCs will be presented, which enable the detection of temperatures below and on the surface of the TBC simultaneously.
Considering process variations during system-level power analysis (2006)

Process variations will increasingly impact the operational characteristics of integrated circuits in nanoscale semiconductor technologies. Researchers have proposed various design techniques to address process variations at the mask, circuit, and logic levels. However, as the magnitude of process variations increases, their effects will need to be addressed earlier in the design cycle.In this paper, we propose techniques for accurately and efficiently incorporating the effects of process variations into system-level power estimation tools. To motivate our work, we first study the impact of process variations on the power consumption of an example System-on-Chip (SoC). We consider simple extensions of current approaches to system-level power estimation (spreadsheet-based and simulation-based power estimation), and demonstrate their limitations in performing variation-aware power estimation. We propose a system-level power estimation methodology that can accurately and efficiently analyze the impact of process variations on SoC power. The proposed methodology combines efficient trace-based analysis, power-state based leakage modeling, and Monte Carlo sampling. The key benefit of the proposed methodology is that it captures the necessary inter-dependencies while avoiding iterative system-level simulation. Our implementation of the proposed techniques within an in-house system-level power estimation framework indicates 2-5 orders of magnitude efficiency gains, with negligible loss in accuracy, compared to direct Monte Carlo techniques that require iterative system simulation.
ChemInform Abstract: Vanadium, Niobium and Tantalum (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Processing of color, form, and motion in macaque area V2 (1996)

We investigated the representation of color in cortical area V2 of macaque monkeys, and the association of color with other stimulus attributes. We measured the selectivity of individual V2 neurons for color, motion, and form. Most neurons in V2 were orientation selective, about half of them were selective for color, and a minority of cells (about 20%) were selective for size or direction. We correlated these physiological measurements with the anatomical location of the cells with respect to the cytochrome oxidase (CO) compartments of area V2. There was a tendency for color-selective cells to be found more frequently in the thin stripes, but color-selective cells also occurred frequently in thick stripes and inter-stripes. We found no difference in the degree of color selectivity between the different CO compartments. Furthermore, there was no negative correlation between color selectivity and selectivity for other stimulus attributes. We found many cells capable of encoding information along more than one stimulus dimension, regardless of their location with respect to the CO compartments. We suggest that area V2 plays an important role in integrating information about color, motion, and form. By this integration of stimulus attributes a cue invariant representation of the visual world might be achieved.
Highly Stable Bioluminescence-Based Fiber-Optic Sensor Using Immobilized Enzymes fromVibrio Harveyi (1989)

Abstract The properties of the bioluminescent enzymatic systems from V. fischeri and V.harveyi immobilized on preactivated polyamide membranes, as well as the characteristics of a fiber-optic biosensor equipped with such membranes, have been studied. Particular attention has been paid to the stability of the bioactive matrices under working conditions, since this remains a key-point for designing operational biosensors of practical use. Whatever the origin of the bioluminescent system, the microdetermination of NADH could be performed at the nanomolar level with detection limits of 2 nM and 0.3 nM with the systems from V. harveyi and V. fischeri, respectively. the use of polyethyleneglycol (PEG 600) improves the operational stability of the bi-enzymatic system from V. fischeri, but a recalibration must be carried out every ten assays. Although the immobilized system from V. harveyi exhibited a lower activity than the enzymes from V. fischeri, its excellent operational stability (100 assays performed within a day without loss in activity) makes it more suitable in designing a truly operational bioluminescence-based NADH sensor.
Efficient interference cancellation scheme for wireless body area network (2011)

In this paper, we propose and simulate an efficient interference cancellation scheme with an optimal ordering successive interference cancellation (SIC) algorithm for ultra wideband (UWB)/multiple-input-multiple-output (MIMO) systems in a wire- less body area network (WBAN). When there are several wireless communication devices on a human body, multiple access interference (MAI) usually occurs. To mitigate the effect of MAI and achieve additional diversity gain, we utilize SIC with an optimal ordering algorithm. A zero correlation duration (ZCD) code with robust MAI capability is employed as a spread code for UWB systems in a multi-device WBAN environment. The performance of the proposed scheme is evaluated in terms of the bit error rate (BER). Simulation results confirm that the BER performance can be improved significantly if the proposed interference cancellation scheme and the ZCD code are jointly employed.
Simple and Double Emulsions via Coaxial Jet Electrosprays (2007)

We report for the first time the generation of electrified coaxial jets of micrometric diameter in liquid media. Scaling laws to predict the inner and outer diameter of the coaxial jet are given. We show some experiments illustrating the formation process of the coaxial jet, and demonstrate how this process can be used to yield either o/w (oil in water) or o/w/o (oil/water/oil) emulsions of micrometric size. Some interesting analogies with other hydrodynamic focusing processes are also pointed out.
Analgesic narcotic antagonists. 5. 7,7-Dimethyldihydrocodeinones and 7,7-dimethyldihydromorphinones (1981)

Treatment of dihydrocodeinone (1a) or the 8 beta-methyl (1b) or 8 beta-ethyl (1c) analogues with formaldehyde-Ca(OH)2 in aqueous dioxane gave the corresponding 7,7-bis(hydroxymethyl)-6 beta-ols 2a-c. Ditosylation of 2, followed by LiEt3BH reduction, gave either the 7,7-dimethyl-6 beta-ol (6a) or 7 alpha-methyl-6 beta, 7 beta-oxetane compounds (5b,c). Compounds 5b and 5c were cleaved to 6b or 6c using LiAlH4-AlCl3. The configuration of the C6-alcohol group of 6a was confirmed by an oxidation-reduction sequence which gave the 7,7-dimethyl-5 alpha-ol 8a. Oxidation of 6 gave the C6-ketones 7a-c, which were converted to N-(cycloalkylmethyl) derivatives 11 and 12 and their corresponding 3-hydroxy compounds 14 and 15. The 3-methoxy-7,7-dimethyl-6-ones 7 were as active as dihydrocodeinone in agonist assays. One compound of this series, N-(cyclopropylmethyl)-7,7-dimethyldihydronorcodeinone (11a), was a potent mixed agonist-narcotic antagonist.
Comparison of induced and independent major depressive disorders in 2,945 alcoholics (1997)

These results support the contention that it is possible to differentiate between what appear to be substance-induced and independent depressive episodes in alcoholics. Such differentiation might be important for establishing prognosis and optimal treatment.
Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis Patients (2022)

Brush catheters are more likely to collect the intestinal mucus inner layer, whereas net catheters are more likely to collect larger samples that include the outer mucus layer, as well as the intestinal fluid. Two sampling methods with different types of collection of the mucosa may lead to different results among patients with mucosal vulnerabilities.
Abstract 17697: Long-Term Dietary Nitrite and Nitrate Deficiency Causes Metabolic Syndrome, Endothelial Dysfunction, and Cardiovascular Death in Mice (2017)

Background: Nitric oxide (NO) is synthesized not only from L-arginine by NO synthases (NOSs), but also from its inert metabolites, nitrite and nitrate (NOx). Green leafy vegetables are abundant in ...
TiO2-Anatase Nanowire Dispersed Composite Electrode for Dye-Sensitized Solar Cells (2007)

TiO2 anatase nanowires have been prepared by a hydrothermal process followed by post-heat treatment in air. TiO2 nanoparticle/TiO2 nanowire composite electrodes were prepared for dye-sensitized solar cells (DSC) in order to improve light-to-electricity conversion efficiency. The TiO2 NP/TiO2NW composite cells showed higher DSC performance than ordinary nanoparticle cells and fully nanowire cells: efficiency (η = 6.53 % for DSC with 10% nanowire, whereas 5.59% for 0% nanowire, and 2.42% for 100% nanowire.
A diagnostic ATPG for delay faults based on genetic algorithms (2002)

This paper presents a GA-based technique to generate diagnostic-oriented delay tests for logic circuits. The aim is to produce a test sequence for a given circuit such that any couple of non-equivalent delay faults is distinguished by at least one rest pair belonging to the test sequence. For this purpose, we decided to preferably use a simulation-based approach with a directed search mechanism rather than developing a new deterministic ATPG. An appropriate fitness function that ranks population members according to their diagnostic capabilities has been defined, and genetic operators allowing a population to evolve during successive generations are presented. In order to have a diagnostic program providing near-optimal solutions, we combined the GA-based technique proposed in this paper with an existing post test diagnostic method for delay faults. Experimental results show that the genetic approach is effective for solving our diagnostic test generation problem, and point out the fact that the GA performs very well in comparison to a random test method.
Active control of rotating stall in axial compressors (1992)

March 1992
Structure-Activity Studies with the Selective Rat Toxicant Norbormide1 (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure-Activity Studies with the Selective Rat Toxicant Norbormide1G. I. Poos, R. J. Mohrbacher, E. L. Carson, V. Paragamian, B. M. Puma, C. R. Rasmussen, and A. P. RoszkowskiCite this: J. Med. Chem. 1966, 9, 4, 537–540Publication Date (Print):July 1, 1966Publication History Published online1 May 2002Published inissue 1 July 1966https://doi.org/10.1021/jm00322a021RIGHTS & PERMISSIONSArticle Views177Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (431 KB) Get e-Alerts Get e-Alerts
Dynamic analysis of Ada programs for comprehension and quality measurement (2008)

During maintenance and particularly during corrective and perfective tasks, systems tend to exhibit a weight gain. As a result, their quality tends to degrade. Software comprehension is vital in order to assess system quality. In this paper, we aim at deploying dynamic analysis of Ada programs for obtaining comprehension, and applying measurements to assess their quality. Program instrumentation is performed non-intrusively by AspectAda, an aspect-oriented extension to Ada which we discussed in earlier work. Events which are required for this analysis are captured as execution traces. We have defined a relational database schema to save execution traces, and a set of queries to obtain measures of quality metrics. New Ada-specific metrics are introduced and existing metrics have been adopted from the literature. Automation is also provided as a proof of concept through a prototypical tool which provides information on the run-time behavior of the system, performs measurements and provides visualization of the run-time behavior of the system through a call graph. An open source Ada program is used as a case study to demonstrate our approach.
Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Epithelial–Mesenchymal Transition (2019)

Epithelial-mesenchymal transition (EMT) is a process that takes place during embryonic development, wound healing, and under some pathological processes, including fibrosis and tumor progression. The molecular changes occurring within epithelial cells during transformation to a mesenchymal phenotype have been well studied. However, to date, the mechanism of EMT induction remains to be fully elucidated. Recent findings in the field of intercellular communication have shed new light on this process and indicate the need for further studies into this important mechanism. New evidence supports the hypothesis that intercellular communication between mesenchymal stroma/stem cells (MSCs) and resident epithelial cells plays an important role in EMT induction. Besides direct interactions between cells, indirect paracrine interactions by soluble factors and extracellular vesicles also occur. Extracellular vesicles (EVs) are important mediators of intercellular communication, through the transfer of biologically active molecules, genetic material (mRNA, microRNA, siRNA, DNA), and EMT inducers to the target cells, which are capable of reprogramming recipient cells. In this review, we discuss the role of intercellular communication by EVs to induce EMT and the acquisition of stemness properties by normal and tumor epithelial cells.