gebhart/patrepeval huggingface dataset:
Modulation of P-glycoprotein, cytochrome P450, and glutathione-S-transferase by resveratrol in human cancer cells (2011)

Resistance of cancer cells to chemotherapy is controlled by a decrease of intracellular drug accumulation, increase of detoxification, and diminished propensity of cancer cells to undergo apoptosis. ABC-membrane transporters together with intracellular metabolic enzymes contribute to the complex and unresolved phenomenon of multidrug resistance (MDR). Resveratrol, a polyphenol of Fallopia japonica (Houtt.) Ronse Decr., has antiinflammatory and antioxidant properties [1]. However, it is also interesting in the field of cancer therapy [2]. The mechanisms by which resveratrol might produce anticancer effects are not well understood. In this study, resveratrol was shown to increase Rho123 and calcein accumulation in a concentration dependent manner (1–500µM) in Caco-2 cells by 3–167% and 5–361% of verapamil. Morever, the treatment of CEM/ADR5000 with 10–100µM resveratrol significantly inhibited the Rho123 and calcein efflux by 107–407%, and 164–460% as compared with verapamil (100%), respectively. The cytotoxicity of doxorubicin was enhanced by using 20µM resveratrol; IC50 values were decreased from 4.15 to 1.23µM, and from 33.67 to 1.81µM, respectively. Furthermore, resveratrol significantly inhibited GST and cytochrome P450 enzyme activity in a dose dependent manner with IC50 values 33.30µM and 11.49µM, respectively. RT-PCR reveals a significantly down-regulation of ABC-transporters and of smetabolic enzymes mRNA levels in Caco-2 cell lines in response to resveratrol treatment. In conclusion, the inhibition of both ABC-transporters and of metabolic enzymes could explain the advantages of resveratrol in cancer therapy.
Optical and hard X-ray detections of an outburst from Aquila X-1 (2009)

We report a new outburst from the neutron star X-ray transient Aquila X-1. Optical monitoring with the Faulkes Telescopes North and South show a rise above quiescence by 0.4 mag in V and i' on 2009-03-07. The magnitudes on that date (MJD 54897.76) were V=18.82 +- 0.09; i'=17.32 +- 0.12. Three days before, on 2009-03-04 (MJD 54894.65) we had V=19.31 +- 0.15; i'=17.73 +- 0.18, which are consistent with the quiescent magnitudes of V=19.21 +- 0.10; i'=17.74 +- 0.07 (ATel #1218).
Skill-based Model-based Reinforcement Learning (2022)

Model-based reinforcement learning (RL) is a sample-efficient way of learning complex behaviors by leveraging a learned single-step dynamics model to plan actions in imagination. However, planning every action for long-horizon tasks is not practical, akin to a human planning out every muscle movement. Instead, humans efficiently plan with high-level skills to solve complex tasks. From this intuition, we propose a Skill-based Model-based RL framework (SkiMo) that enables planning in the skill space using a skill dynamics model, which directly predicts the skill outcomes, rather than predicting all small details in the intermediate states, step by step. For accurate and efficient long-term planning, we jointly learn the skill dynamics model and a skill repertoire from prior experience. We then harness the learned skill dynamics model to accurately simulate and plan over long horizons in the skill space, which enables efficient downstream learning of long-horizon, sparse reward tasks. Experimental results in navigation and manipulation domains show that SkiMo extends the temporal horizon of model-based approaches and improves the sample efficiency for both model-based RL and skill-based RL. Code and videos are available at https://clvrai.com/skimo
Immobilization/stabilization of acid urease on Eupergit® supports (2012)

The adsorption capacity and immobilization rate of two Eupergit® supports for acid urease was studied by varying the ionic strength and enzyme preparation concentration in the immobilizing solution at pH 7. Eupergit® C250 L yielded a series of derivatives with enzyme loadings (Y(P/B)) ranging from 48 to 171 mg of bovine serum albumin equivalent (BSAE) per gram of dry support (ds). Use of drastic postimmobilization conditions at pH 9 for 3-9 days yielded a slight decrease (8-14%) in the initial activity of immobilized enzymes and a limited increase in the stabilization factor (1.1-1.5), as assessed by accelerated aging tests at 65 °C. Further storage tests at 4 °C in the wet state showed that the activity of several derivatives either stabilized or not was practically constant for as long as 547 days. Both free enzyme and immobilized acid urease derivatives exhibited a kinetic pattern of the Michaelis-Menten type. Using the Eadie-Hofstee diagram, the specific ammonia formation rate constant for free (k(cat)) or immobilized (k'(cat)) enzyme resulted to be little affected by immobilization (k(cat) ≈ k'(cat) ≈ 18.86 ± 0.34 IU/mg BSAE), whereas the apparent Michaelis constant for immobilized enzymes exhibited a statistically significant increase at P < 0.05 from the intrinsic value (2.55 ± 0.14 mM) for free enzyme to 5.38 ± 0.87 mM as Y(P/B) increased to 171 mg BSAE/g ds. By estimating the observable Thiele modulus (Φ(obs) ), the activity of the biocatalyst with the greatest enzyme loading at the lowest urea concentrations tested (0.833 mM) was reduced by a factor of about 2 due to internal diffusional limitations. By operating in the pseudofirst-order regime with immobilized derivatives at Y(P/B) about 126 mg BSAE/g ds, their activity after grinding was no more limited by intraparticle diffusion and approached the value for free enzyme.
Parameters of the Dzyaloshinsky-Moriya type weak ferromagnetism for some perovskite compounds (2007)

Compounds with distorted perovskite structure of the 4-f and 3-d transition metals with the common formula LnTO3 (where Ln is rare-earth element, T is an element from the Fe group) are the most multifold binary oxides of these two groups elements. Wide range of stability for this structure allows the realization of combinations of the Lanthanides with all the transition metals except the Nickel. Quite interesting physical phenomena take place in these oxides like charge and orbital ordering; relatively independent magnetic lattices of the both metals; particular magnetic structures; high optical indicators; giant magneto-resistance; peculiar dielectric and ferroelectric properties etc. We have investigated the magnetic properties of pure ferrites and chromium-based materials as well as of some mixed type oxides like HoxTb1-xO3, HoMnxFe1-xO3, HoMnxCr1-xO3 and DyFexCr1-xO3.
Equine H7N7 influenza A viruses are highly pathogenic in mice without adaptation: potential use as an animal model (1991)

Equine H7N7 influenza A viruses, representing a broad range of isolates, were lethal in mice without adaptation. After repeated passages, A/Equine/London/1416/73 acquired neurotropism upon intranasal infection. Thus, mice infected with equine influenza A viruses provide a model system for the study of highly virulent mammalian influenza viruses.
Platform-dependent code generation for embedded real-time software (2013)

Code generation for embedded systems is challenging, since the generated code (e.g., C code) is expected to run on a heterogeneous set of target platforms with different characteristics, such as hardware/software architectures and programming interfaces. We propose a code generation framework that provides the flexibility to generate different source code that is executable on each target platform. In our framework, the platform-dependent characteristics of a target platform are explicitly specified by an Architectural Analysis Description Language (AADL) model and a code snippet repository. The AADL model captures hardware/software architectural aspects of the platform, such as periodic/aperiodic threads and their interactions with sensors and actuators. The code snippet repository contains platform-dependent code snippets that are categorized according to the functions required to implement the components of the AADL model. These two elements of the platform capability are then used by the code generation algorithm to generate platform-dependent code for the given platform. We demonstrate the applicability of our framework using a case study of code generation for two infusion pump systems.
Overlapping Statistical Segmentation for Effective Indexing of Japanese Text. (1999)

Because word boundaries are not clearly indicated in Asian languages, including Japanese, word indexing cannot be applied easily. Although dictionary-based methods for segmenting text enable word indexing, they give rise to some problems, such as dictionary maintenance. N-Gram indexing, another commonly used method, suffers from low retrieval performance and increase in index size. This paper proposes a new statistical indexing method. It uses a new measure, computed using statistics about characters to evaluate a bi-gram's likelihood of being a word boundary, and a new segmentation strategy which extracts some overlapping segments in addition to the segments extracted using the current strategy. As a result, our method achieves higher retrieval effectiveness.
Bioadhesion of Polyion Complex (PlC) Hydrogels Composed of Amphiphilic Phospholipid Polymers (2007)

To investigate the tissue adhesive function of a hydrogel composed ofbiocompatible amphiphilic polymers, random and graft polymers were prepared from 2-methacryloyloxyethyl phosphorylcholine (MPC), electrolyte monomers and hydrophobic n-butyl methacrylate (BMA). The results of the fluorescence study suggested enhanced electrostatic interaction in the graft polymers compared to the random polymers. This is due to the strategically designed architectures and the hydrophobic BMA units. The results of the cytotoxicity test showed that the cytotoxicity of the MPC polymers was lower than that of glutaraldehyde, which is a crosslinking agent in the aldehyde-type tissue adhesives and is known to cause serious side effects. The cationic MPC polymers demonstrated higher cytotoxicity compared to the anionic ones, which demonstrated no significant cytotoxicity. The tissue adhesion of the PlC hydrogels was lower than that of a commercially available fibrin glue. However, the tissue adhesive strength increased with an increase in the polymer concentration and could be controlled by the water content of the hydrogel. In addition, balance of the electrolyte units for the PIC formation and the tissue adhesion is crucial for expression of adhesion. Although further investigation of the biocompatibility is required, it can be concluded that the PlC hydrogels fonned by the amphiphilic MPC polymers can be a promising tissue adhesive which demonstrate tissue adhesion and biocompatibility according to the architectures and chemical structures.
Evaluation of a high-power three-phase dual active bridge DC-DC converter with three-level phase-legs (2016)

A three-phase dual active bridge (DAB) converter with three-level phase-legs is analyzed, showing an increased soft-switching region and a reduction in rms current in the ac-link for unequal input and output voltages compared to the conventional two-level circuit. Furthermore, a comparison of the semiconductor losses is carried out for different three-level inverter implementations using commercially available silicon (Si) and silicon-carbide (SiC) power modules. The lowest losses are found for the T-type implementation with a combination of SiC and Si power modules. Experimental results, obtained from a high-power prototype, are included to support the evaluation of the three-level three-phase DAB.
Modélisation des paramètres de contrôle pour la synthèse de voix chantée (2016)

National audience
UNION: A Trust Model Distinguishing Intentional and Unintentional Misbehavior in Inter-UAV Communication (2018)

Ensuring the desired level of security is an important issue in all communicating systems, and it becomes more challenging in wireless environments. Flying Ad Hoc Networks (FANETs) are an emerging type of mobile network that is built using energy-restricted devices. Hence, the communications interface used and that computation complexity are additional factors to consider when designing secure protocols for these networks. In the literature, various solutions have been proposed to ensure secure and reliable internode communications, and these FANET nodes are known as Unmanned Aerial Vehicles (UAVs). In general, these UAVs are often detected as malicious due to an unintentional misbehavior related to the physical features of the UAVs, the communication mediums, or the network interface. In this paper, we propose a new context-aware trust-based solution to distinguish between intentional and unintentional UAV misbehavior. The main goal is to minimize the generated error ratio while meeting the desired security levels. Our proposal simultaneously establishes the inter-UAV trust and estimates the current context in terms of UAV energy, mobility pattern, and enqueued packets, in order to ensure full context awareness in the overall honesty evaluation. In addition, based on computed trust and context metrics, we also propose a new inter-UAV packet delivery strategy. Simulations conducted using NS2.35 evidence the efficiency of our proposal, called <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>U</mml:mi><mml:mi>N</mml:mi><mml:mi>I</mml:mi><mml:mi>O</mml:mi><mml:mi>N</mml:mi></mml:math>, at ensuring high detection ratios &gt; 87% and high accuracy with reduced end-to-end delay, clearly outperforming previous proposals known as <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>R</mml:mi><mml:mi>P</mml:mi><mml:mi>M</mml:mi></mml:math>, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mrow><mml:mi>T</mml:mi></mml:mrow></mml:math>-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M4"><mml:mi>C</mml:mi><mml:mi>L</mml:mi><mml:mi>A</mml:mi><mml:mi>I</mml:mi><mml:mi>D</mml:mi><mml:mi>S</mml:mi></mml:math>, and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M5"><mml:mi>C</mml:mi><mml:mi>A</mml:mi><mml:mi>T</mml:mi><mml:mi>r</mml:mi><mml:mi>u</mml:mi><mml:mi>s</mml:mi><mml:mi>t</mml:mi></mml:math>.
Synthesis of Hydroxyapatite by Hydrolysis of .ALPHA.-TCP. (1999)

Hydroxyapatite whisker and platelet were synthesised by the hydrolysis of alpha-tricalcium phoshate (α-TCP) in H2O system and etanol/H2O system at 70°C and atmospheric pressure, thus avoiding severe processing condition, such as in hydrothermal synthesis. The hydroxyapatite prepared by this process was analysed by X-ray diffractometry and transmission electron microscopy observation. The effect of ethanol addition into H2O on the hydrolysis of α-TCP to hydroxyapatite was also examined. The hydrolysis rate of α-TCP to hydroxyapatite was inhibited in the ethanol/H2O system. It was found that the morphology and the aspect ratio of hydroxyapatite could be controlled by adding ethanol into H2O during the hydrolysis reaction of α-TCP.
Similarities between Fusobacterium nucleatum and Bacteroides fragilis studied by two DNA probes derived from Fusobacterium nucleatum (1994)

A polymerase chain reaction (PCR)-amplified oligonucleotide DNA probe corresponding to a Fusobacterium nucleatum Fevl DNA region coding for a 40-kDa major outer-membrane protein (OMP) and a randomly cloned 2.1 kb DNA probe were found to recognize DNA from the Gram-negative bacteria Fusobacterium nucleatum and Bacteroides fragilis on Southern blots and slot blots. The results indicate sequence similarity within the DNA fragments studied. Immunoblots tested with polyclonal antibodies against whole cells of F. nucleatum revealed only weak antigen similarity between these species.
Wavelength Assignment for Physical-Layer-Impaired Optical Networks Using Evolutionary Computation (2011)

This paper presents a wavelength assignment algorithm suitable for optical networks mainly impaired by physical layer effects, named the Intelligent Wavelength Assignment algorithm (iWA). The main idea is to determine the wavelength activation order for a first-fit algorithm that balances the impact of the physical layer effects by using a training algorithm inspired by evolutionary concepts. The iWA presents some recently proposed concepts in intelligent optimization algorithms, such as an external archive to store the best solutions. Some different physical layer effects, such as four-wave mixing and residual dispersion, were considered in the tests of our proposal. We tested our proposal for transparent optical networks. However, we believe iWA can be used in other types of network, such as opaque networks and translucent networks. The proposed wavelength assignment algorithm was compared with five other wavelength assignment algorithms for two network topologies in three different scenarios. The iWA algorithm outperformed the other WA algorithms in most cases. The robustness of our proposed algorithm to the load distribution changes was also analyzed.
A Novel TIMP3 Mutation Associated With Sorsby Fundus Dystrophy (2005)

Sorsby fundus dystrophy (SFD), originally described by Sorsby and Mason in 1949, 1 is a rare autosomal dominant retinal degeneration. To date, 8 mutations in the tissue inhibitor of metalloproteinases 3 (TIMP3) gene on chromosome 22q13 have been described in patients with SFD. 2 Herein we describe clinical features in a family of Eastern European-Jewish ancestry with a novel TIMP3 mutation.
Infinite Variational Autoencoder for Semi-Supervised Learning (2016)

This paper presents an infinite variational autoencoder (VAE) whose capacity adapts to suit the input data. This is achieved using a mixture model where the mixing coefficients are modeled by a Dirichlet process, allowing us to integrate over the coefficients when performing inference. Critically, this then allows us to automatically vary the number of autoencoders in the mixture based on the data. Experiments show the flexibility of our method, particularly for semi-supervised learning, where only a small number of training samples are available.
Combined Cytolytic Effects of a Vaccinia Virus Encoding a Single Chain Trimer of MHC-I with a Tax-Epitope and Tax-Specific CTLs on HTLV-I-Infected Cells in a Rat Model (2014)

Adult T cell leukemia (ATL) is a malignant lymphoproliferative disease caused by human T cell leukemia virus type I (HTLV-I). To develop an effective therapy against the disease, we have examined the oncolytic ability of an attenuated vaccinia virus (VV), LC16m8Δ (m8Δ), and an HTLV-I Tax-specific cytotoxic T lymphocyte (CTL) line, 4O1/C8, against an HTLV-I-infected rat T cell line, FPM1. Our results demonstrated that m8Δ was able to replicate in and lyse tumorigenic FPM1 cells but was incompetent to injure 4O1/C8 cells, suggesting the preferential cytolytic activity toward tumor cells. To further enhance the cytolysis of HTLV-I-infected cells, we modified m8Δ and obtained m8Δ/RT1AlSCTax180L, which can express a single chain trimer (SCT) of rat major histocompatibility complex class I with a Tax-epitope. Combined treatment with m8Δ/RT1AlSCTax180L and 4O1/C8 increased the cytolysis of FPM1V.EFGFP/8R cells, a CTL-resistant subclone of FPM1, compared with that using 4O1/C8 and m8Δ presenting an unrelated peptide, suggesting that the activation of 4O1/C8 by m8Δ/RT1AlSCTax180L further enhanced the killing of the tumorigenic HTLV-I-infected cells. Our results indicate that combined therapy of oncolytic VVs with SCTs and HTLV-I-specific CTLs may be effective for eradication of HTLV-I-infected cells, which evade from CTL lysis and potentially develop ATL.
Comparison of beamforming and spectral autocorrelation method applied on ambient noise data acquired with a small aperture array (2020)

peer reviewed
Modular Strategies for Structure and Function Employed by Marine Cyanobacteria: Characterization and Synthesis of Pitinoic Acids (2013)

Novel bioactive lipids were identified from a Guamanian cyanobacterium, the &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; quorum sensing inhibitor pitinoic acid A (&lt;b&gt;1&lt;/b&gt;) and the anti-inflammatory pitinoic acids B (&lt;b&gt;2&lt;/b&gt;) and C. The structure of &lt;b&gt;2&lt;/b&gt; was confirmed by synthesis, which also allowed for biological evaluation. Since &lt;b&gt;2&lt;/b&gt; is an ester of pitinoic acids A and C, it represents a prodrug strategy to liberate dual biological activity for the management of &lt;i&gt;P. aeruginosa&lt;/i&gt; infections and their associated inflammation.
High in-hospital blood pressure variability and severe disability or death in primary intracerebral hemorrhage patients (2019)

Quantification of HSBPV is feasible utilizing routinely collected systolic blood pressure readings, and a singular cut-off parameter for systolic blood pressure variability demonstrated association with 90-day severe disability or death. Elderly, female, and patients with high admission systolic blood pressure may be more likely to demonstrate HSBPV during hospitalization.
Assessing public perception of self-driving cars (2019)

We introduce the Autonomous Vehicle Acceptance Model (AVAM), a model of user acceptance for autonomous vehicles, adapted from existing models of user acceptance for generic technologies. A 26-item questionnaire is developed in accordance with the model and a survey conducted to evaluate 6 autonomy scenarios. In a pilot survey (n = 54) and follow-up survey (n = 187), the AVAM presented good internal consistency and replicated patterns from previous surveys. Results showed that users were less accepting of high autonomy levels and displayed significantly lower intention to use highly autonomous vehicles. We also assess expected driving engagement of hands, feet and eyes which are shown to be lower for full autonomy compared with all other autonomy levels. This highlighted that partial autonomy, regardless of level, is perceived to require uniformly higher driver engagement than full autonomy. These results can inform experts regarding public perception of autonomy across SAE levels. The AVAM and associated questionnaire enable standardised evaluation of AVs across studies, allowing for meaningful assessment of changes in perception over time and between different technologies.
Comments on “An Open Ocean Trial of Controlled Upwelling Using Wave Pump Technology” (2010)

Corresponding author address: Philip W. Kithil, 607 Cerrillos, Atmocean, Inc., Santa Fe, NM 87505. E-mail: atmocean.kithil@gmail.comThe original article that was the subject of this comment/reply can be found at http://journals.ametsoc.org/doi/abs/10.1175/2009JTECHO679.1.
New state records for Nearctic false click beetles (Coleoptera: Eucnemidae) (2017)

Otto, Robert L., Karns, Ken D. (2017): New state records for Nearctic false click beetles (Coleoptera: Eucnemidae). Insecta Mundi 2017 (582): 1-21, DOI: 10.5281/zenodo.5169274