gebhart/patrepeval huggingface dataset:
Induction Therapy in the Current Immunosuppressive Therapy (2022)

The current immunosuppressive therapy including calcineurin inhibitors, mycophenolate mofetil, and steroids, has substantially suppress rejections and improved clinical outcomes in heart transplant (HTx) recipients. Nevertheless, the management of drug-related nephrotoxicity, fatal acute cellular rejection (ACR), antibody-mediated rejection and infections remains challenging. Although previous some studies suggested that perioperative induction immunosuppressive therapy may be effective for the suppressing ACR and deterioration of renal function, increased incidence of infection and malignancy was concerned in recipients with induction immunosuppressive therapy. The international society of heart and lung transplantation (ISHLT) guidelines for the care of heart transplant recipients do not recommend routine use of induction immunosuppressive therapy, except for the patients with high risk of acute rejection or renal dysfunction, however, appropriate therapeutic regimen and indication of induction immunosuppressive therapy remains unclear in HTx recipients. We review current evidence of induction immunosuppressive therapy in HTx recipients, and discuss the appropriate therapeutic regimen and indication of induction therapy.
NEXT-CRAB-0: A High Pressure Gaseous Xenon Time Projection Chamber with a Direct VUV Camera Based Readout (2023)

The search for neutrinoless double beta decay ($0νββ$) remains one of the most compelling experimental avenues for the discovery in the neutrino sector. Electroluminescent gas-phase time projection chambers are well suited to $0νββ$ searches due to their intrinsically precise energy resolution and topological event identification capabilities. Scalability to ton- and multi-ton masses requires readout of large-area electroluminescent regions with fine spatial resolution, low radiogenic backgrounds, and a scalable data acquisition system. This paper presents a detector prototype that records event topology in an electroluminescent xenon gas TPC via VUV image-intensified cameras. This enables an extendable readout of large tracking planes with commercial devices that reside almost entirely outside of the active medium.Following further development in intermediate scale demonstrators, this technique may represent a novel and enlargeable method for topological event imaging in $0νββ$.
Data from Physical Activity, Tumor PTGS2 Expression, and Survival in Patients with Colorectal Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Higher levels of physical activity are associated with lower colorectal carcinoma incidence and mortality, perhaps through influencing energy balance, cellular prosta7 systemic inflammation. Although evidence suggests interactive effects of energetics, sedentary lifestyle, and tumor CTNNB1 (β-catenin) or CDKN1B (p27) status on colon cancer prognosis, interactive effects of physical activity and tumor PTGS2 (the official symbol for COX-2) status on clinical outcome remain unknown.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; Using molecular pathological epidemiology database of 605 stage I–III colon and rectal cancers in two prospective cohort studies (the Nurse's Health Study and the Health Professionals Follow-up Study), we examined patient survival according to postdiagnosis physical activity and tumor PTGS2 status (with 382 PTGS2-positive and 223 PTGS2-negative tumors by immunohistochemistry). Cox proportional hazards models were used to calculate colorectal cancer-specific mortality HR, adjusting for clinical and other tumor variables including microsatellite instability status.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Among PTGS2-positive cases, compared with the least active first quartile, the multivariate HRs (95% confidence interval) were 0.30 (0.14–0.62) for the second, 0.38 (0.20–0.71) for the third, and 0.18 (0.08–0.41) for the fourth quartile of physical activity level (&lt;i&gt;P&lt;/i&gt;&lt;sub&gt;trend&lt;/sub&gt; = 0.0002). In contrast, among PTGS2-negative cases, physical activity level was not significantly associated with survival (&lt;i&gt;P&lt;/i&gt;&lt;sub&gt;trend&lt;/sub&gt; = 0.84; &lt;i&gt;P&lt;/i&gt;&lt;sub&gt;interaction&lt;/sub&gt; = 0.024, between physical activity and tumor PTGS2 status).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Postdiagnosis physical activity is associated with better survival among patients with PTGS2-positive tumors but not among patients with PTGS2-negative tumors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Impact:&lt;/b&gt; Immunohistochemical PTGS2 expression in colorectal carcinoma may serve as a predictive biomarker in pathology practice, which may predict stronger benefit from exercise. &lt;i&gt;Cancer Epidemiol Biomarkers Prev; 22(6); 1142–52. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Observations on the Life History of Antilochus cocquerberti, a Predator of Dysdercus koenigi1 (1966)

Journal Article Observations on the Life History of Antilochus cocquerberti, a Predator of Dysdercus koenigi Get access Abdul R. Chauthani, Abdul R. Chauthani 2 College of Agriculture, Gwalion, M. P. India 2Present address: Southern Grain Insects Research Laboratory, Georgia Coastal Plain Experiment Station, Tifton. Search for other works by this author on: Oxford Academic PubMed Google Scholar U. S. Misra U. S. Misra 3 College of Agriculture, Gwalion, M. P. India 3Present address: College of Agriculture, Gwalion, M. P. India. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 59, Issue 3, 1 June 1966, Pages 767–768, https://doi.org/10.1093/jee/59.3.767 Published: 01 June 1966 Article history Accepted: 07 February 1966 Published: 01 June 1966
Lieu commun (1991)

Ma recherche porte sur l'intégration du dessin et de la sculpture. Le projet d'exposition se présente sous la forme d'une installation où se fusionnent les deux pratiques. Le travail exposé a ses racines dans l'exploration à grande échelle d'un mode sculptural régi par une approche plutôt formaliste et dans l'esprit de spontanéité d'une pratique plus libre du dessin. L'expérience de conjugaison des deux disciplines a comme prétexte une relation spatiale. Elle renvoie à un environnement, à des éléments architecturaux: du mobilier, aux effets de climat, aux souvenirs d'activités. Le lieu commun, d'apparence banale, se révèle sous une autre identité ou sous sa vraie nature pour se prêter à une expérience esthétique. Il s'est offert comme occasion de création pour se métamorphoser en Lieu Commun. L'intégration des deux pratiques a permis de questionner chacune des catégories et d'expérimenter certains moyens de les fusionner.
Enhancement of hole injection and electroluminescence by ordered Ag nanodot array on indium tin oxide anode in organic light emitting diode (2014)

We report the enhancement of hole injection and electroluminescence (EL) in an organic light emitting diode (OLED) with an ordered Ag nanodot array on indium-tin-oxide (ITO) anode. Until now, most researches have focused on the improved performance of OLEDs by plasmonic effects of metal nanoparticles due to the difficulty in fabricating metal nanodot arrays. A well-ordered Ag nanodot array is fabricated on the ITO anode of OLED using the nanoporous alumina as an evaporation mask. The OLED device with Ag nanodot arrays on the ITO anode shows higher current density and EL enhancement than the one without any nano-structure. These results suggest that the Ag nanodot array with the plasmonic effect has potential as one of attractive approaches to enhance the hole injection and EL in the application of the OLEDs.
Bayesian Spatial Multivariate Receptor Modeling for Multisite Multipollutant Data (2017)

For the development of effective air pollution control strategies, it is crucial to identify the sources that are the principal contributors to air pollution and estimate how much each source contributes. Multivariate receptor modeling aims to address these problems by decomposing ambient concentrations of multiple air pollutants into components associated with different source types. With the expanded monitoring efforts that have been established over the past several decades, extensive multivariate air pollution data obtained from multiple monitoring sites (multisite multipollutant data) are now available. Although considerable research has been conducted on modeling multivariate space-time data in other contexts, there has been little research on spatial multivariate receptor models for multisite, multipollutant data. We present a Bayesian spatial multivariate receptor modeling (BSMRM) approach that can incorporate spatial correlations in multisite, multipollutant data into the estimation of source composition profiles and contributions, based on discrete process convolution models for multivariate spatial processes. The new BSMRM approach enables predictions of source contributions at unmonitored sites as well as simultaneously dealing with model uncertainty caused by the unknown number of sources and identifiability conditions. The new approach can also provide uncertainty estimates for the predicted source contributions at any location, which was not possible in previous multivariate receptor modeling approaches. The proposed approach is applied to 24-hour ambient air concentrations of 17 Volatile Organic Compounds (VOCs) measured at nine monitoring sites in Harris County, Texas, between 2003 and 2005. Supplementary materials for this article, including real data and MATLAB codes for implementing BSMRM, are available online on the journal web site.
Tuning Different Kinds of Entangled Networks Formed by Isomers of Bis(1,2,4-triazol-1-ylmethyl)benzene and a Flexible Tetracarboxylate Ligand (2013)

In order to tune the Zn(II) coordination polymer architectures, three position isomers, 1,4- (pbtmb), 1,3- (mbtmb), and 1,2-bis(1,2,4-triazol-1-ylmethyl)benzene (obtmb), and flexible tetracarboxylate ligand, 5,5′-(1,4-phenylenebis(methylene))bis(oxy)diisophthalic acid (H4L1), were used to assemble compounds with different kinds of entangled networks, namely, {[Zn2(L1)(pbtmb)2]·4H2O}n (1), {[Zn2(L1)(mbtmb)2]·4H2O}n (2), and [Zn2(L1)(obtmb)2]n (3). Flexible bis(triazole) ligands present diverse conformations in these compounds. Compound 1 shows a 4-fold interpenetrating three-dimensional architecture with 4-connected mog (moganite) topology. Compound 2 displays a 2D + 2D → 3D polycatenation network simplified as new 4-connected topology with the Schlafli notation of {4,64;8}2{42,64}. Compound 3 is a 2D polythreading structure, in which two layed networks interpenetrate in a (2D/2D) parallel fashion. The powder X-ray diffraction, thermal stabilities, and the photoluminescence of 1–3 have also been investigated.
Effect of RU Addition on Cast Nickel Base Superalloy with Low Content of CR and High Content of W (2000)

The effect of Ru on two kinds of cast nickel-base superalloys in as-cast, heat-treated and oxidation tested specimens has been characterised by optical metallography and scanning electron microscopy. The evaluation of microstructure confirms the distribution of Ru in various phases, the beneficial role of Ru in stabilising microstructure, delaying formation of M& and increasing incipient melting temperature of the alloys. The role of Ru oh oxidation resistance is different in various kinds of alloy; in Hf-bearing alloys, it has a beneficial effect, but in a 1.5% Cr alloy, the effect of Ru is not obvious.
Chemie der Isoblausäure, 9. Dreikomponenten‐Cycloadditionen mit Cyanokomplexen (1993)

Chemistry of Hydrogen Isocyanide, 9 [1] . — Three‐Component Cycloadditions with Cyano Complexes A novel and obviously general reaction of the coordinated cyano ligand in [M(CN)(CO) 5 ] — (M = Cr, W) is reported, viz. its high‐yield one‐step [2 + 1 + 2] cycloaddition with a great variety of isocyanides and ketones resulting in carbenoid metal complexes of five‐membered N,O heterocycles. The structure of the product 1a from [W(CN)(CO) 5 ] — , tert ‐butyl isocyanide, and diethyl ketone has been elucidated by X‐ray diffraction and found to contain a C‐bound non‐aromatic 4‐aminooxazoline with an unprecedented π‐delocalization along the magnified image exo chain which is also evident from severe low‐field shifts of the C‐2 and C‐4 signals in the 13 C‐NMR spectra. The heterocycles are cleaved off the metal by oxidative decomposition with KMnO 4 /Fe(NO 3 ) 3 to give the corresponding oxazolinones, e.g. 4 , with a high potential for biological activity. The general validity of this reactivity pattern for metal cyanides is further demonstrated by the successful incorporation of cyanoiron(II) and ‐cobalt(III) species in these three‐component cycloaddition reactions.
Design, simulation, and characterization of a radial opposed migration ion and aerosol classifier (ROMIAC) (2017)

We present the design, simulation, and characterization of the radial opposed migration ion and aerosol classifier (ROMIAC), a compact differential electrical mobility classifier. We evaluate the performance of the ROMIAC using a combination of finite element modeling and experimental validation of two nearly identical instruments using tetra-alkyl ammonium halide mass standards and sodium chloride particles. Mobility and efficiency calibrations were performed over a wide range of particle diameters and flow rates to characterize ROMIAC performance under the range of anticipated operating conditions. The ROMIAC performs as designed, though performance deviates from that predicted using simplistic models of the instrument. The underlying causes of this non-ideal behavior are found through finite element simulations that predict the performance of the ROMIAC with greater accuracy than the simplistic models. It is concluded that analytical performance models based on idealized geometries, flows, and fields should not be relied on to make accurate <i>a priori</i> predictions about instrumental behavior if the actual geometry or fields deviate from the ideal assumptions. However, if such deviations are accurately captured, finite element simulations have the potential to predict instrumental performance. The present prototype of the ROMIAC maintains its resolution over nearly three orders of magnitude in particle mobility, obtaining sub-20 nm particle size distributions in a compact package with relatively low flow rate operation requirements. © 2017 American Association for Aerosol Research
Physical properties and subunit structure of l-asparaginase isolated from Erwinia carotovora (1972)

1. l-Asparaginases from Erwinia carotovora and Escherichia coli (EC2 enzyme) are both capable of inhibiting and eliminating certain types of tumour cells. The Er. carotovora enzyme is a more basic protein, however, and in contrast with the EC2 enzyme it contains neither tryptophan nor cystine, and disulphide bonds are therefore absent. The molecule is very stable in solution from pH3.0 to about pH12.0, and is somewhat more stable at alkaline pH than is the Esch. coli enzyme. Calculations based on a s020,w 7.43S and a sedimentation-equilibrium molecular weight of 135000±10000 give a frictional ratio (f/f0) of 1.08. The molecular conformation is therefore very compact in solution, and the electron microscope shows the negatively stained molecules as almost spherical particles with a diameter of 7.2±0.7nm. 2. Sedimentation-velocity and equilibrium ultracentrifugation, in 5–8m solutions of urea and guanidinium chloride, and also electrophoresis in sodium dodecyl sulphate–polyacrylamide gel, reveal a dissociation of the native protein molecule into four subunits of similar molecular weight in the range 32500–38000. The enzymically inactive subunits can be physically reassembled into an active tetramer when urea is removed by dialysis. Although the subunit structures of the Er. carotovora enzyme and the Esch. coli enzyme molecules are similar, the secondary bonding forces holding the subunits together in the tetramer are somewhat stronger in the Er. carotovora enzyme. 3. The optical-rotatory-dispersion (o.r.d.) parameters that characterize the Cotton effects arising from ordered structure in the molecule are [m′]233=−3522±74° and [m′]200=9096±1700°. These show very marked changes as the secondary structure is disrupted and the molecule dissociates into subunits. A correlation pathway was traced on the basis of o.r.d. parameters and enzyme activity as the polypeptide chains were denatured and renatured (and reconstituted) into active molecules after the dilution of solutions in urea. Subunits resulting from treatment with sodium dodecyl sulphate do not show the typically disordered o.r.d. profile, but nevertheless they are inactive.
Collapse Simulations of Steel-Concrete Composite Floors under Column Loss Scenarios (2020)

Characterizing structural resiliency after severe damage to a few load-carrying members is challenging. Engineers use various computational approaches to assess the vulnerability of structures and to evaluate the parameters that affect their response. Few of these approaches are capable of predicting the actual peak load-carrying capacity a damaged structure can withstand before experiencing total collapse, and practically none of them have been verified against actual test results. In this paper, experimental data from large-scale tests on steel–concrete composite floor systems under different column loss scenarios were used to develop and to validate a high-fidelity numerical modeling approach capable of predicting the response of the tests up to total collapse. This approach incorporates geometric and material nonlinearity, explicit modeling of steel and concrete failure, and contact modeling using LS-DYNA version R10.2.0. Nearly all specimen components were modeled using brick elements, including the concrete slab, steel members, bolts, and other connecting elements. The corrugated metal decking was represented with shell elements, and beam elements represent the reinforcing steel and shear studs. The predicted response and ultimate load–carrying capacity up to total collapse show good agreement with the results of the experimental tests. Validating the numerical models revealed the sensitivity of various modeling parameters and demonstrated the potential for inaccurate predictions of response when certain parameters were not correctly specified. The most important of these parameters are described in this manuscript. Lessons learned from the current study are helpful for understanding the mechanisms that have the greatest impact on collapse of composite floor systems, and these lessons can be used to gain insight on the collapse potential of other structures with different geometries or configurations.
The optimal deghosting algorithm for broadband data combination (2009)

Data acquisition with concurrently towed shallow and deep streamers leads to deeper penetration and increased resolution. These benefits are achieved by using data processing algorithms that combine data acquired at different depths into a single dataset. However, the conventional algorithms used for this purpose do not consider the presence of noise. We present the optimal deghosting (ODG) algorithm which increases the bandwidth by optimizing the signal‐to‐noise ratio (SNR) of the combined data. The ODG algorithm estimates the statistics of the noise on shallow and deep streamers and minimizes the residual noise on the deg‐hosted data in a least‐squares sense. Hence, by optimally combining the data from streamers at different depths, the ODG method results in a broad bandwidth with enhanced low‐frequency response and optimal SNR.
Implementing Quality of Service and Confidentiality for Batch Processing Applications (2018)

With a massive volume of information generated from many kinds of sources and for many different purposes comes the need for processing systems that help digest these data. One approach for efficient processing of data is to batch process larger sets of data. For example, periodically, recent data can be analyzed and filtered, having as a result actions, updated models, or cleaned versions of the data uploaded to databases. Increasingly often, such applications have strong requirements regarding data security, quality of service, and scalability. While scalability is typically addressed by leveraging the abundant resources and fair pricing of cloud computing techniques, using a shared environment triggers resistance from developers regarding data security and quality of service. In this work, we present a system that combines a novel technology for data protection, Intel SGX, with a popular, open source tool for managing interactive and data processing applications, Kubernetes, to provide a batch processing system that is easy to use while still providing quality of service and strong confidentiality guarantees. Our evaluation shows that independent tasks that consume data from scalable storages can be implemented in a controllable, secure fashion, without added complexity or considerable performance or resource overheads.
Tachykinins (Substance P, Neurokinin A, Neuropeptide K, and Neurokinin B) in the Cerebral Circulation: Vasomotor Responses in vitro and in situ (1991)

The vasomotor responses of tachykinins have been studied in the cerebral vasculature of human, pig, cat, and guinea pig. Substance P (SP), neurokinin A (NKA), neurokinin B (NKB), and neuropeptide K (NPK) induced concentration-dependent relaxations of precontracted cerebral arteries in all species when examined by a sensitive in vitro technique. In addition, the relaxant responses to SP, NKA, and NKB were studied in cat pial arterioles by peptide microapplication in situ. In human pial vessels, the order of relaxant potency was SP greater than NKB greater than NKA greater than NPK; in the pig middle cerebral artery, there was no difference in potency between the tachykinins; in the cat middle cerebral artery, SP = NKB greater than NKA = NPK; and in the guinea pig basilar artery, SP much greater than NPK = NKA greater than NKB. Responses induced by SP, NKA, and NKB in the cat were comparable in vitro and in situ. Removal of the endothelium abolished relaxation induced by all four tachykinins. The relaxant responses of guinea pig basilar arteries to SP, NKA, and NPK were competitively antagonized by the SP antagonist Spantide. However, Spantide lowered the Imax of the NKB concentration-response curve without any rightward shift, suggesting action at a different site than the other tachykinins. In the guinea pig basilar artery, the relaxation seems to be exerted via a NK-1 receptor subtype while the receptor subtype is more unclear in cerebral arteries from human, cat, and pig.(ABSTRACT TRUNCATED AT 250 WORDS)
IoT enabled waste management system using ZigBee network (2017)

With rapid urbanization, industrialization and population growth in India, solid waste management is becoming the key challenge for state governments and local municipal bodies. The garbage containers that are placed at public places are found to be overflowing frequently due to increase in the daily waste disposal. In this research, IoT (Internet of Things) enabled waste management system using ZigBee network and MQTT (Message Queue Telemetry Transport) protocol is proposed to determine filled status of the garbage container. The data acquisition module placed within the container updates the server via ZigBee coordinator, whenever the level of the garbage reaches the threshold. MQTT is a lightweight protocol and it provides the communication link between coordinator and the server. Optimal path for collecting the filled containers is determined in the server using Haversine formula and travelling salesman algorithm. The information is intimated to the garbage collection unit through Telegram messaging application to minimize time and fuel cost.