gebhart/patrepeval huggingface dataset:
The Risk of Secondary Myelodysplastic Syndrome/Acute Leukemia and Second Malignancy Following Yttrium-90 Ibritumomab Tiuxetan: 10-Year Single-Institution Experience of 138 Consecutive Patients (2012)

Abstract Abstract 4876 Here we report one single centre experience with 90Y Ibritumomab tiuxetan in order to investigate the incidence of treatment-related myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) or second malignancies after90Y Ibritumomab tiuxetan. From 2001 to 2012 a total of 138 patients received radioimmunotherapy (RIT) with 90Y ibritumomab tiuxetan at European Institute of Oncology; 35 patients had Diffuse Large B Cell Lymphoma (DLBCL), 8 Mantle Cell Lymphoma (MCL), 61 Follicular Lymphoma (FL), 4 transformed FL, 27 Marginal Zone Lymphoma (MZL), 1 transformed MZL, 1 lymphoplasmacytoid lymphoma and 1 Burkitt. At time of treatment patients had a median age of 63 years (range, 21–85), 67 female and 71 male. They had received a median of 3 prior therapies (range, 1–11), including Rituximab, Radiotherapy and High Dose-Chemotherapy. 90Y Ibritumomab Tiuxetan was administered at the activity of 14.8 MBq/kg in 98 patients, at 11.1 MBq/kg in 14 patients due to mild thrombocytopenia. Two patients had received 90Y Ibritumomab Tiuxetan at further relapse (respectively 14.8 MBq/kg and 11.1 MBq/kg). In an experimental program - where PBSC transplantation was performed - an activity of 30 MBq/kg was delivered in 4 patients, 45 MBq/kg in 6 patients and 56 MBq/kg in 16 patients. After RIT 65 patients underwent further treatments due to relapse or progression, 7 patients underwent SC mobilization – with successful collection in 4 patients - and autologous transplantation. With a median follow-up of 3 years (range 0–10.3), 2 patients developed MDS (they had received 30 and 45MBq/kg respectively) and 3 patients AML (2 patients had received 14.8 MBq/kg, 1 patient 56 MBq/kg), with an incidence of 3.6%. Events occurred at a median of 8 years (range, 6–10) after diagnosis of NHL and 3.8 years (range 2–5) after RIT. Multiple cytogenetic aberrations detected - principally involving chromosome 7 and 5 - time from diagnosis and previous treatments received, all support the correlation with previous CT as the result of cumulative damage rather than it being directly related to RIT. Finally 4 patients developed second malignancy with an incidence of 2.9%. CONCLUSION: RIT does not appear to significantly increase the risk of second malignancies. These data suggest that the damage that leads to the development of second malignancy is probably cumulative and multifactorial. The incidences of MDS, AML or second tumors after 90Y Ibritumomab tiuxetan are consistent with that expected if we consider the patients' treatment history. However a preliminary assessment of patient characteristics may help in identifying those most at risk: cytogenetic testing should be performed before RIT to verify pre-existing chromosomal abnormalities in heavily pretreated patients, in elderly patients and those previously exposed to alkylating agents or purine nucleoside analogs. Disclosures: No relevant conflicts of interest to declare.
CO2Adsorption-Based Separation by Metal Organic Framework (Cu-BTC) versus Zeolite (13X) (2009)

The potential for the metal organic framework (MOF) Cu-BTC to selectively adsorb and separate CO2 is considered. Isotherms for CO2, CH4, and N2 were measured from 0 to 15 bar and at temperatures between 25 and 105 °C. The isotherms suggest a much higher working capacity (×4) for CO2 adsorption on Cu-BTC relative to the benchmark zeolite 13X over the same pressure range. Higher CO2/N2 and CO2/CH4 selectivities in the higher pressure range (1−15 bar) and with lower heats of adsorption were also demonstrated. Cu-BTC was observed to be stable in O2 at 25 °C, but its crystallinity was reduced in humid environments. The CO2 adsorption capacity was progressively reduced upon cyclic exposure to water vapor at low relative humidity (<30%), but leveled out at 75% of its original value after several water adsorption/desorption cycles.
KA'CI WOMAN OF THE ARAWAK AND THE KARINABU/CARIB HER SOUND/lNG (1999)

then the island dreamt in my blood tina the river swam in my eyes the soft green hills the blue world of sky and bara'wa
Interaction of Glycyrrhizin and Glycyrrhetinic Acid with DNA (2011)

Glycyrrhizin (GL), a molecule of glycyrrhetinic acid (GA), is an aqueous extract from licorice root. These compounds are well known for their anti-inflammatory, hepatocarcinogenesis, antiviral, and interferon-inducing activities. This study is the first attempt to investigate the binding of GL and GA with DNA. The effect of ligand complexation on DNA aggregation and condensation was investigated in aqueous solution at physiological conditions, using constant DNA concentration (6.25 mM) and various ligands/polynucleotide (phosphate) ratios of 1/240, 1/120, 1/80, 1/40, 1/20, 1/10, 1/5, 1/2, and 1/1. Fourier transform infrared and ultraviolet (UV)-visible spectroscopic methods were used to determine the ligand binding modes, the binding constants, and the stability of ligand-DNA complexes in aqueous solution. Spectroscopic evidence showed that GL and GA bind DNA via major and minor grooves as well as the backbone phosphate group with overall binding constants of K(GL-DNA)=5.7×10(3) M(-1), K(GA-DNA)=5.1×10(3) M(-1). The affinity of ligand-DNA binding is in the order of GL>GA. DNA remained in the B-family structure, whereas biopolymer aggregation occurred at high triterpenoid concentrations.
Unsteady Vortex Behaviour of a Rotating 65° Delta Wing Using Pressure Sensitive Paint (PSP) (2006)

Visualization and measurements of aerodynamic effects on a delta-wing model were conducted using an optical pressure measurement system, based on the pressure-sensitive paint (PSP) technique. A special 65° delta wing, the so called DLR-PSP model, was tested in the transonic wind tunnel DNW-TWG in Göttingen. A rolling apparatus was built up to enable roll rates up to 10 Hz. The experiments were carried out at angles-of-attack up to alpha = 17° at Ma = 0.8. For this rotating model an unsteady PSP technique was successfully applied.&#13;\n
Privacy preserving data mining (2004)

Securing data against intruders attacking implicit sensitive information is an open research problem. In order to make a publicly available system secure, we must ensure not only that private sensitive data have been trimmed out, but also that certain inference channels have been blocked as well. Moreover, the need to make a system as open as possible - to the degree that data sensitivity is not jeopardized - asks for techniques that account for the disclosure control of sensitive data. In this context an European project (Codmine) was developed in order to reach the following objectives: (a) Investigation of new techniques for privacy preserving data mining; (b) Implementation and testing of newly proposed techniques for privacy preserving data mining; (c) Specification of an evaluation framework in order to compare all the techniques in a common platform.
Equal gain transmission in multiple-input multiple-output wireless systems (2003)

Multiple-input multiple-output (MIMO) wireless systems are of interest due to their ability to provide substantial gains in capacity and quality. The paper proposes equal gain transmission (EGT) to provide diversity advantage in MIMO systems experiencing Rayleigh fading. The applications of EGT with selection diversity combining, equal gain combining, and maximum ratio combining are addressed. It is proven that systems using EGT with any of these combining schemes achieve full diversity order when transmitting over a memoryless, flat-fading Rayleigh matrix channel with independent entries. Since, in practice, full channel knowledge at the transmitter is difficult to realize, a quantized version of EGT is proposed. An algorithm to construct a beamforming vector codebook that guarantees full diversity order is presented. Monte-Carlo simulation comparisons with various beamforming and combining systems illustrate the performance as a function of quantization.
Genetic Analysis of the Saccharomyces cerevisiae RHO3 Gene, Encoding a Rho-Type Small GTPase, Provides Evidence for a Role in Bud Formation (1996)

RHO3 encodes a Rho-type small GTPase of the yeast Saccharomyces cerevisiae. We isolated temperature-sensitive alleles and a dominant active allele of RHO3. Ts- rho3 cells lost cell polarity during bud formation and grew more isotropically than wild-type cells at nonpermissive temperatures. In contrast, cells carrying a dominant active mutant RHO3 displayed cold sensitivity, and the cells became elongated and bent, often at the position where actin patches were concentrated. These phenotypes of the rho3 mutants strongly suggest that RHO3 is involved in directing the growing points during bud formation. In addition, we found that SRO6, previously isolated as a multicopy suppressor of rho3, is the same as SEC4. The sec4-2 mutation was synthetic lethal with temperature-sensitive rho3 mutations and suppressed the cold sensitivity caused by a dominant active mutant RHO3. The genetic interactions between RHO3 and SEC4, taken together with the fact that the Rab-type GTPase Sec4p is required to fuse secretory vesicles together with plasma membrane for exocytosis, support a model in which the Rho3p pathway modulates morphogenesis during bud growth via directing organization of the actin cytoskeleton and the position of the secretory machinery for exocytosis.
Percutaneous Ethanol Sclerotherapy for Recurrent Adventitial Cystic Disease of External Iliac Vein after Surgical Treatment: A Case Report (2015)

Adventitial cystic disease (ACD) is an uncommon condition that accounts for only 0.1% of all vascular disease (1), and it mainly affects young men with intermittent claudication. It is most commonly seen in the popliteal artery, but it has also been reported in the external iliac, femoral, ulnar and radial arteries. Very few reports of this disease have been described in the venous system such as the common femoral vein, the popliteal vein, the wrist area veins, the lesser saphenous vein and the external iliac vein (2). Surgery has been known to be a standard therapy for this disease. Also there have been reports about less invasive technique such as percutaneous aspiration and angioplasty. However, several recurrences have been reported in these less invasive therapies (3). To the best of our knowledge, there is no report about management of recurrent ACD after surgery with percutaneous drainage and use of absolute ethanol as sclerosis agent. Here we report a case of successful treatment by percutaneous drainage and ethanol sclerotherapy for recurrent ACD of left external iliac vein that was previously treated by cyst excision and patch angioplasty.
Physical Models for Music and Animated Image: The Use of CORDIS-ANIMA in "ESQUISSES"; a Music Film by ACROE (1994)

International audience
Effective Targeting Of Chronic Myeloid Leukemia Initiating Activity With The Combination Of Arsenic Trioxide and Interferon Alpha (2013)

Abstract Imatinib is the standard of care in the treatment of Chronic Myeloid Leukemia (CML) patients. However, imatinib is not curative since most patients who discontinue therapy will relapse, stressing the need for novel therapies that target leukemia initiating cells (LIC). Arsenic trioxide induces complete remission in patients with acute promyelocytic leukemia (APL). We previously demonstrated that, through full degradation of PML-RARA, the combination of arsenic and retinoic acid eradicates APL LICs and cures the disease. Interferon alpha (IFN) induces hematologic and cytogenetic remissions and interestingly, improved outcome was reported with the combination of interferon and imatinib. We investigated the effects of arsenic and IFN on human CML cell lines or primary cells and the bone marrow retroviral transduction/transplantation murine CML model. In vitro, the combination of arsenic and IFN inhibited proliferation and activated apoptosis. Importantly, arsenic and IFN synergistically reduced the clonogenic activity of primary bone marrow cells derived from CML patients. Moreover, in a murine transplantation model of CML, we show that arsenic/IFN prolonged survival of primary leukemic mice and sharply diminished transplantation of CML cells in secondary recipients, pointing to exhaustion of CML LICs. Our results also suggest that IFN/arsenic may clear LICs independently from oncoprotein catabolism. Interestingly, arsenic/IFN effect on CML LIC activity was significantly superior to that of imatinib.These studies plea for a clinical exploration of this combination, knowing that IFN and arsenic have both shown clinical activity in CML, alone or in combination with imatinib. Disclosures: No relevant conflicts of interest to declare.
Cost function design for modeling information overload in radar systems (2019)

It is a common assumption that more effective decisions can be made in radar sensor processing if more “information" is available. However, this is not always the case since more information may not necessarily translate to better sensor performance due to a phenomenon known as information overload. What determines the effectiveness of a decision is rarely only dependent on a single performance metric. Instead, there are often multiple performance metrics involved. This necessitates the use of cost functions for modeling a loss in decision effectiveness due to deviations from the optimal values of the performance metrics. These optimal values are also often determined in a fuzzy/subjective manner by an individual using language. Two different types of statements are looked at and modeled, namely, soft and hard constraining statements. These models, called language-based cost functions (LBCFs), are derived and their properties are explored. These can then be easily combined, via a summation, to obtain a smooth objective function. The objective function is then used to find the utility of the radar system. By altering the systems parameter values the amount of information introduced into the system can be varied and the point at which the utility of the radar system decreases due to excess information can be found. This is then regarded as the information overload point or the point at which more information causes a decrease in the utility of the system. An example of a radar system with imposed constraints is provided and its resulting information overload point is found by utilizing LBCFs.
Impeding corrosion of sintered NdFeB magnets with titanium nitride coating (2009)

Abstract Sintered NdFeB magnets have poor corrosion resistance that renders them susceptible to corrosion in industrial and marine environments. This paper evaluates the properties of cathodic arc physical vapour deposited (CAPVD) titanium nitride coating for corrosion protection of sintered NdFeB permanent magnets. The performance of titanium nitride coating has been compared to the electrodeposited nickel–copper–nickel multilayer coating. The rates of coatings degradation in simulated marine environment were estimated with electrochemical impedance spectroscopy (EIS). Cyclic polarization was carried out to assess the pitting potential. The surface chemistry and coating morphologies were studied with scanning electron microscope (SEM). X‐ray diffraction (XRD) was used for qualitative phase analyses of coatings and the substrate. It was figured out that the charge transfer resistance of CAPVD titanium nitride coating increased with exposure time. The negative rate of Rp‐degradation for titanium nitride coating compared to the nickel–copper–nickel multilayer for equivalent exposure time is a unique and valuable result. Polarization results showed that ‘pits re‐passivation’ of titanium nitride coating could be responsible for the extended corrosion protection of the NdFeB substrate. The magnetic properties remained comparable for both types of coatings.
Wireless clinical alerts for critical medication, laboratory and physiologic data (2005)

A fully interfaced clinical information system (CIS) contains physiologic, laboratory, blood gas, medication and other data that can be used as the information base for a comprehensive alerting system. Coupled with an event driven rules engine, a CIS can generate clinical alerts which may both prevent medical errors and assist caregivers in responding to critical events in a timely way. The authors have developed a clinical alerting system which delivers alerts and reminders to clinicians in real time via a alphanumeric display pagers. This paper will describe the system, the type and number of alerts generated, and the impact on clinical practice. A major issue remains in measuring the impact of wireless alerts on patient outcomes.
A cryptographic protocol to obtain secure communications in extended Ethernet environment (2003)

An implementation of a security protocol in an extended LAN environment is described. The protocol has a hierarchical architecture. At the first level, the session key is disposed of, in the second level there are the master keys, and at the highest level there are the public and private key of the manager and the CryptoNet's keys. The relations between them, the right time to do the keys' renewal, and the appropriate form in which to do it are also characteristics that make it possible to obtain security based on two very well known algorithms such as the DES and RSA.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Prognosis of Performing Split-Rib Bone Graft for Cranial Bone Defects (2023)

Therapeutic, IV.
A NEW WING TIP WITH IMPROVED LIFT, DRAG AND STALL PERFORMANCE (1997)

Improvements in aircraft performance and the saving of lives, may be possibe, simply, from improvements in wing-tip design.
Theta-like specimen to determine tensile strength at the micro scale (2010)

Micro- and nano-electromechanical systems are typically formed via lithographic and etching processes that leave residual surface features, stresses, and chemistry that ultimately control component strength and thus device and system reliability. Here, we describe a new test specimen for micro-scale tensile strength measurements that allows for direct assessment of surface effects on strength. Specimens were formed from silicon-on-insulator wafers by deep reactive ion etching and tested with instrumented indentation. The experimental results were interpreted using finite element analyses to extract fracture strength. Fracture strengths as great as 3 GPa were observed, with fracture initiating at processing-induced flaws and propagating along {111} and {110} planes.
Embolization of experimentally created aneurysms with intravascular stent devices. (1994)

Treatment of selected intracranial aneurysms via an endovascular approach has merit and could supplant more invasive, risky, and costly surgical procedures in some cases.
A MEMS diamond hemispherical resonator (2013)

In this paper we report the fabrication of hemispherical polycrystalline diamond resonators fabricated on a novel high-temperature glass substrate. The hemispherical resonator gyroscope is one of the most accurate and rugged of the mechanical gyroscopes, and can be operated in either rate or whole-angle mode due to its high degree of symmetry. A fabrication sequence for creating extremely symmetric 3D MEMS hemispheres is presented. Mode shapes and frequencies obtained with a laser vibrometer are shown, as well as curves of Q versus pressure, and the dependence of frequency on anchor size. Fundamental mode frequency matching to <0.1% in as-fabricated devices has been achieved, which is essential to gyroscope operation in whole-angle mode.
The role of vascular endothelial growth inhibitor in wound healing (2007)

Vascular endothelial growth inhibitor (VEGI) is an endothelial cell-specific cytokine and a potent inhibitor of endothelial cell proliferation and angiogenesis. The role of VEGI in angiogenesis related to tissue repair has previously not been investigated. Biopsies from different wound types were analysed by immunohistochemistry and quantitative polymerase chain reaction for the presence of VEGI protein and transcript, respectively. Human vascular endothelial cell line was transfected with VEGI expression plasmid and tested for their in vitro angiogenesis properties. Immunohistochemical staining for VEGI showed reduced expression in the dermal layer of the acute wounds compared with the chronic wound or normal skin. The ability of VEGI to prevent angiogenesis by in vitro assays showed that VEGI acts as a suppressor to the proliferation and microtubule formation of endothelial cells, and the addition of Hepatocyte Growth Factor had little effect on the ability of cell lines expressing the VEGI gene to increase microtubule formation. The aberrant expression of VEGI in different wound types appears to be linked to the outcome of the healing in these wounds. The altered expression of VEGI in chronic wounds constitutes an important target of future therapies.
High performance of a solid-state flexible asymmetric supercapacitor based on graphene films (2012)

Solid-state flexible energy storage devices hold the key to realizing portable and flexible electronic devices. Achieving fully flexible energy storage devices requires that all of the essential components (i.e., electrodes, separator, and electrolyte) with specific electrochemical and interfacial properties are integrated into a single solid-state and mechanically flexible unit. In this study, we describe the fabrication of solid-state flexible asymmetric supercapacitors based on an ionic liquid functionalized-chemically modified graphene (IL-CMG) film (as the negative electrode) and a hydrous RuO(2)-IL-CMG composite film (as the positive electrode), separated with polyvinyl alcohol-H(2)SO(4) electrolyte. The highly ordered macroscopic layer structures of these films arising through direct flow self-assembly make them simultaneously excellent electrical conductors and mechanical supports, allowing them to serve as flexible electrodes and current collectors in supercapacitor devices. Our asymmetric supercapacitors have been optimized with a maximum cell voltage up to 1.8 V and deliver a high energy density (19.7 W h kg(-1)) and power density (6.8 kW g(-1)), higher than those of symmetric supercapacitors based on IL-CMG films. They can operate even under an extremely high rate of 10 A g(-1) with 79.4% retention of specific capacitance. Their superior flexibility and cycling stability are evident in their good performance stability over 2000 cycles under harsh mechanical conditions including twisted and bent states. These solid-state flexible asymmetric supercapacitors with their simple cell configuration could offer new design and fabrication opportunities for flexible energy storage devices that can combine high energy and power densities, high rate capability, and long-term cycling stability.
LXXIII.—Studies in colour and constitution. Part I. The influence of the methylthiol group, alone and in conjunction with the methoxy-group (1926)

H. H. Hodgson and F. W. Handley, J. Chem. Soc., 1926, 129, 542 DOI: 10.1039/JR9262900542
Expression of HIF-1α in Ischemia and Reperfusion in Human Microsurgical Free Muscle Tissue Transfer (2011)

This study shows that ischemia and reperfusion induce alterations on the gene expression level in human muscle free flaps. Data from this study indicate that the expression of HIF-1α might not be affected but that other putative pathways of ischemic regulation might be of great interest. Finally, these findings correspond with the surgeon's clinical experience that the accepted times of ischemia, generally up to 90 minutes, are not sufficient to induce pathophysiologic processes, which can ultimately lead to flap loss.