gebhart/patrepeval huggingface dataset:
TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling (2017)

Heterozygous germ-line mutations in the bone morphogenetic protein type-II receptor (BMPR-II) gene underlie heritable pulmonary arterial hypertension (HPAH). Although inflammation promotes PAH, the mechanisms by which inflammation and BMPR-II dysfunction conspire to cause disease remain unknown. Here we identify that tumour necrosis factor-α (TNFα) selectively reduces BMPR-II transcription and mediates post-translational BMPR-II cleavage via the sheddases, ADAM10 and ADAM17 in pulmonary artery smooth muscle cells (PASMCs). TNFα-mediated suppression of BMPR-II subverts BMP signalling, leading to BMP6-mediated PASMC proliferation via preferential activation of an ALK2/ACTR-IIA signalling axis. Furthermore, TNFα, via SRC family kinases, increases pro-proliferative NOTCH2 signalling in HPAH PASMCs with reduced BMPR-II expression. We confirm this signalling switch in rodent models of PAH and demonstrate that anti-TNFα immunotherapy reverses disease progression, restoring normal BMP/NOTCH signalling. Collectively, these findings identify mechanisms by which BMP and TNFα signalling contribute to disease, and suggest a tractable approach for therapeutic intervention in PAH.
Dead Man Tweeting (2016)

This paper presents a prototype — Dead Man Tweeting — of a system that learns semantic avatars from (dead) people’s texts, and makes the avatars come alive on Twitter. The system includes a languag ...
Compressive Sensing recovery with improved hybrid filter (2013)

Compressive Sensing (CS) is a novel sampling framework which is more efficient than the Nyquist sampling for sparse signals. A major challenge in CS is its quality improvement of recovered signal when noise exists. To reduce noise in the recovered images, filters are usually employed. This paper focuses on improving the quality of CS recoveries by applying a hybrid filter which pursues smoothness and preserves edge at the same time. Considering desirability of the block-based recovery in practical usages, the proposed hybrid filter is investigated not only for the frame-based recovery but also for the block-based recovery. Experimental results demonstrate that the proposed hybrid filter attains much better performance in CS recovery than the conventional ones in term of both subjective and objective qualities.
Taller Princeton. The periphery. (1992)

Sobre la "Route 1 Corridor" entre les capitals provincials de Trenton i New Bruswick i la ciutat universitària de Princeton.
5th Int. workshop on human activity sensing corpus and applications (HASCA) (2017)

Technological advances enable the inclusion of miniature sensors (e.g., accelerometers, gyroscopes) on a variety of wearable/portable information devices. Most current devices utilize these sensors for simple orientation and gesture recognition only. However, in the future the recognition of more complex and subtle human behaviors from these sensors will enable next-generation human-oriented computing in scenarios of high societal value (e.g., dementia care). This will require large-scale human activity corpuses and much improved methods to recognize activities and the context in which they occur. This workshop deals with the challenges of designing reproducible experimental setups, running large-scale dataset collection campaigns, designing activity and context recognition methods that are robust and adaptive, and evaluating systems in the real world. As a special topic this year, we wish to reflect on the challenges and possible approaches to recognize situations, events or activities outside of a statically pre-defined pool, which is the current state of the art, and instead adopt an open-ended view on activity and context awareness. Following the huge success of previous years, we are further planning to share these experiences of current research on human activity corpus and their applications among the researchers and the practitioners and to have a deep discussion on the future of activity sensing, in particular towards open-ended contextual intelligence.
ChemInform Abstract: Conversion of α,β‐Epoxyketones to Diosphenols Using 6‐Methyl‐2‐pyridone Anion as an Hydroxide Equivalent. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Sensor health monitoring using simple data driven approaches (2016)

Present day high end vehicles contain as many as 100 microprocessors and have more than 100 million lines of code [3]. Electronic Control Units (ECUs) use numerous sensors spread across various sub-systems to perform a variety of functions such as stability control, adaptive cruise control, power train control, autonomous driving, etc. The accuracy of sensors degrades over the vehicle lifetime. The control logic of vehicles uses sensor measurements to detect the vehicle state and give appropriate commands to control the vehicle. Faults in sensors cause wrong feedback to be sent to the control logic and subsequently commands given by the control logic become faulty. Thus the effect of a sensor fault can be observed in subsystems controlled by the control logic. So advanced diagnosis techniques are required to detect the sensor degradation. In this work, a comparison is made between two different automotive sensor health monitoring methods used to diagnose sensor faults. The methods that are compared are: lookup table based method and machine learning (using multiple linear regression) based method. The comparison will enable one to choose the appropriate method by considering the attributes required for a particular application like accuracy, amount of computation required, simplicity, etc. Sensor faults are detected by comparing the current sensor output with a nominal no-fault sensor block output at the particular operating point of the system. The lookup table method was implemented in Matlab while the machine learning method was implemented using R programming language. The proposed methods are illustrated on the case example of motor fault in a Hybrid Electric Vehicle to analyze their efficacy. They have been found to be valid for all drive cycles and can be used for diagnosing sensor faults in real time.
The RNA-Binding Protein HuR Posttranscriptionally Regulates the Protumorigenic Activator YAP1 in Pancreatic Ductal Adenocarcinoma (2022)

Yes-associated protein 1 (YAP1) is indispensable for the development of mutant <i>KRAS</i>-driven pancreatic ductal adenocarcinoma (PDAC). High <i>YAP1</i> mRNA is a prognostic marker for worse overall survival in patient samples; however, the regulatory mechanisms that mediate its overexpression are not well understood. <i>YAP1</i> genetic alterations are rare in PDAC, suggesting that its dysregulation is likely not due to genetic events. HuR is an RNA-binding protein whose inhibition impacts many cancer-associated pathways, including the "conserved YAP1 signature" as demonstrated by gene set enrichment analysis. Screening publicly available and internal ribonucleoprotein immunoprecipitation (RNP-IP) RNA sequencing (RNA-Seq) data sets, we discovered that <i>YAP1</i> is a high-confidence target, which was validated <i>in vitro</i> with independent RNP-IPs and 3' untranslated region (UTR) binding assays. In accordance with our RNA sequencing analysis, transient inhibition (e.g., small interfering RNA [siRNA] and small-molecular inhibition) and CRISPR knockout of HuR significantly reduced expression of YAP1 and its transcriptional targets. We used these data to develop a HuR activity signature (HAS), in which high expression predicts significantly worse overall and disease-free survival in patient samples. Importantly, the signature strongly correlates with <i>YAP1</i> mRNA expression. These findings highlight a novel mechanism of YAP1 regulation, which may explain how tumor cells maintain <i>YAP1</i> mRNA expression at dynamic times during pancreatic tumorigenesis.
POPPE'S SILKWORM AND DRYDEN (1983)

Journal Article POPPE'S SILKWORM AND DRYDEN Get access JAMES MEANS JAMES MEANS Université Laval, Québec Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 30, Issue 6, December 1983, Pages 509-a–509, https://doi.org/10.1093/nq/30-6-509a Published: 01 December 1983
Absence of D2S dopamine receptor in the prolactin-secreting MMQ pituitary clone: characterization of a wild D2L receptor coupled to native transduction mechanisms (1995)

We used the PCR amplification technique in an attempt to characterize further the dopamine D2L receptor expressed in the prolactin-secreting pituitary MMQ cell clone, derived from the prolactin- and ACTH-secreting Buffalo rat 7315 alpha pituitary tumour. By semiquantitative PCR amplification we were unable to detect the mRNA encoding the D2S receptor isoform, which derives from the well-known process of alternative splicing, producing two D2 receptor subtypes (D2L and D2S) in such tissues as the anterior pituitary and the corpus striatum. Although the pharmacology of the D2 receptor has been established in many studies on both native receptors and transfected receptor isoforms, because of the lack of tissues naturally expressing only one receptor isoform, MMQ cells represent the first example of cells uniquely or prevalently expressing only the D2L receptor, conceivably coupled to its native transduction mechanisms. These considerations prompted us to evaluate the pharmacology and the second messenger systems known to be modulated by dopamine. Scatchard analysis of [3H]spiperone binding resulted in a linear plot, consistent with the existence of a single class of binding sites, with a Kd of 0.055 +/- 0.002 nM and a Bmax of 27 +/- 3.5 fmol/mg protein. Competition experiments confirmed the GTP-dependence and the order of potency for agonist and antagonist ligands consistent with binding to a D2 receptor. The inhibitory effects of dopamine on adenylyl cyclase activity, inositol phosphate production and intracellular free calcium concentrations, the latter presumably via the opening of K+ channels, and prolactin secretion, as well as the reversal of the effect by the D2-selective antagonist (-)sulpiride and pretreatment with pertussis toxin, are consistent with the known biological actions of dopamine at D2 receptors. Based on our observations, the MMQ cell line can be considered a useful tool for investigating ligand-receptor interactions to develop new selective dopaminergic D2L ligands for the therapy of dopamine-related disorders such as schizophrenia, depression, Parkinson's disease and drug addiction.
Gallozeolite catalysts: preparation, characterization and performance (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGallozeolite catalysts: preparation, characterization and performanceJohn M. Thomas and Xin Sheng LiuCite this: J. Phys. Chem. 1986, 90, 20, 4843–4847Publication Date (Print):September 1, 1986Publication History Published online1 May 2002Published inissue 1 September 1986https://pubs.acs.org/doi/10.1021/j100411a025https://doi.org/10.1021/j100411a025research-articleACS PublicationsRequest reuse permissionsArticle Views175Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Out-of-vocabulary word modeling using multiple lexical fillers (2005)

In large vocabulary speech recognition, out-of-vocabulary words are an important cause of errors. We describe a lexical filler model that can be used in a single pass recognition system to detect out-of-vocabulary words and reduce the error rate. When rescoring word graphs with better acoustic models, word fillers cause a combinatorial explosion. We introduce a new technique, using several thousand lexical fillers, which produces word graphs that can be rescored efficiently. On a large French vocabulary continuous speech recognition task, lexical fillers achieved an OOV detection rate of 44% and allowed a 23% reduction in errors due to OOV words.
The Role of Diet in Functional Dyspepsia Management (2020)

Functional dyspepsia is a common functional gastrointestinal disease that is characterized by postprandial fullness, early satiation, epigastric pain, and/or epigastric burning. Eating a meal is a key factor in the occurrence of symptoms during functional dyspepsia, and patients frequently request dietary advice that could relieve these symptoms. Eating behaviors, irregular meal patterns, and moderate-to-fast eating rates are significantly associated with functional dyspepsia. The role of diet is complex; fat ingestion increases the occurrence of symptoms in dyspeptic patients, which might be affected by cognitive factors and palatability. Data concerning the role of carbohydrates are conflicting. Wheat may induce symptoms in patients with nonceliac gluten/wheat sensitivity, and gluten-free diets might be beneficial. Data concerning the role of FODMAPs (Fructo, Oligo, Di-, Monosaccharides, And Polyols) in functional dyspepsia are lacking; however, as there is a frequent overlap between functional dyspepsia and irritable bowel syndrome, a diet that is low in FODMAPs might be useful in relieving some symptoms. Data concerning alcohol are also conflicting. Adherence to a Mediterranean diet seems to be associated with a decrease in dyspepsia symptoms. Finally, data concerning diet modifications are conflicting, and the impact of diet modifications on symptom intensity or frequency has never been reported in randomized prospective studies. Common sense dietary recommendations, such as eating slowly and regularly, as well as decreasing the fat content of meals, can be provided in daily clinical practice.
Homologous trans -editing factors with broad tRNA specificity prevent mistranslation caused by serine/threonine misactivation (2015)

Aminoacyl-tRNA synthetases (ARSs) establish the rules of the genetic code, whereby each amino acid is attached to a cognate tRNA. Errors in this process lead to mistranslation, which can be toxic to cells. The selective forces exerted by species-specific requirements and environmental conditions potentially shape quality-control mechanisms that serve to prevent mistranslation. A family of editing factors that are homologous to the editing domain of bacterial prolyl-tRNA synthetase includes the previously characterized trans-editing factors ProXp-ala and YbaK, which clear Ala-tRNA(Pro) and Cys-tRNA(Pro), respectively, and three additional homologs of unknown function, ProXp-x, ProXp-y, and ProXp-z. We performed an in vivo screen of 230 conditions in which an Escherichia coli proXp-y deletion strain was grown in the presence of elevated levels of amino acids and specific ARSs. This screen, together with the results of in vitro deacylation assays, revealed Ser- and Thr-tRNA deacylase function for this homolog. A similar activity was demonstrated for Bordetella parapertussis ProXp-z in vitro. These proteins, now renamed "ProXp-ST1" and "ProXp-ST2," respectively, recognize multiple tRNAs as substrates. Taken together, our data suggest that these free-standing editing domains have the ability to prevent mistranslation errors caused by a number of ARSs, including lysyl-tRNA synthetase, threonyl-tRNA synthetase, seryl-tRNA synthetase, and alanyl-tRNA synthetase. The expression of these multifunctional enzymes is likely to provide a selective growth advantage to organisms subjected to environmental stresses and other conditions that alter the amino acid pool.
MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis (2013)

Smoking is a significant risk factor for lung cancer, the leading cause of cancer-related deaths worldwide. Although microRNAs are regulators of many airway gene-expression changes induced by smoking, their role in modulating changes associated with lung cancer in these cells remains unknown. Here, we use next-generation sequencing of small RNAs in the airway to identify microRNA 4423 (miR-4423) as a primate-specific microRNA associated with lung cancer and expressed primarily in mucociliary epithelium. The endogenous expression of miR-4423 increases as bronchial epithelial cells undergo differentiation into mucociliary epithelium in vitro, and its overexpression during this process causes an increase in the number of ciliated cells. Furthermore, expression of miR-4423 is reduced in most lung tumors and in cytologically normal epithelium of the mainstem bronchus of smokers with lung cancer. In addition, ectopic expression of miR-4423 in a subset of lung cancer cell lines reduces their anchorage-independent growth and significantly decreases the size of the tumors formed in a mouse xenograft model. Consistent with these phenotypes, overexpression of miR-4423 induces a differentiated-like pattern of airway epithelium gene expression and reverses the expression of many genes that are altered in lung cancer. Together, our results indicate that miR-4423 is a regulator of airway epithelium differentiation and that the abrogation of its function contributes to lung carcinogenesis.
Combining good dispersion with tailored charge trapping in nanodielectrics by hybrid functionalization of silica (2021)

Abstract Fumed silica-filled polypropylene (PP)-based nanodielectrics were studied in this work. To not only improve the dispersion of the silica but also introduce deep charge traps into the polymeric matrix, five types of modified silicas were manufactured with different surface modifications. The modified silica surfaces comprise an inner and a surface layer. The inner layer contains a polar urethane group for tailoring the charge trap properties of the PP/propylene–ethylene copolymer nanocomposites, whereas the surface layer consists of hydrocarbons (ethyl-, tert -butyl-, cyclopentyl-, phenyl-, or naphthalenyl moieties) in order to gain a good dispersion of the silica in the unpolar polymer blend. Scanning electron microscopic pictures proved that these tailored silicas show a much better dispersion than the unmodified one. Thermally stimulated depolarization current measurements revealed the ability of the silica to introduce deep charge traps with low trap density. The trap depth distribution depends on the type of the unpolar surface layer consisting of the different hydrocarbons. Among these five differently modified silicas, the introduction of the one with a surface layer consisting of tert -butyl moieties resulted in the lowest charge injection and the lowest charge current in the nanocomposite, proving good dielectric performance. Additionally, this silica exhibits good dispersion in the polymeric matrix, indicating a promising performance for nanodielectric application.
VOLUME EXCITATION OF AN ULTRATHIN SINGLE-MODE CdSe LASER (1966)

Ultrathin CdSe lasers of variable mode spacing, including the special case of single-mode output, are described. A simple experimental procedure for volume optical excitation of a thin semiconductor sample is described.
Type I and Type II Photosensitized Oxidative Modification of 2‘-Deoxyguanosine (dGuo) by Triplet-Excited Ketones Generated Thermally from the 1,2-Dioxetane HTMD (1997)

The nucleoside 2‘-deoxyguanosine (dGuo) was treated with 3-(hydroxymethyl)-3,4,4-trimethyl-1,2-dioxetane (HTMD), the latter generates efficiently triplet-excited carbonyl products on thermal decomposition in the dark. The type I photooxidation products, 2,2-diamino-[(2-deoxy-β-d-erythro-pentofuranosyl)-4-amino]-5(2H)-oxazolone (oxazolone) and the cyclic nucleoside 2-(S)-2,5‘-anhydro-1-(2-deoxy-β-d-erythro-pentofuranosyl)-5-guanidinylidene-2-hydroxy-4-oxoimidazolidine (oxoimidazolidine), as well as the type II photooxidation products 4-(R)*- and 4-(S)*-4-hydroxy-8-oxo-4,8-dihydro-2‘-deoxyguanosine (4-HO-8-oxodGuo) and 8-oxo-7,8-dihydro-2‘-deoxyguanosine (8-oxodGuo), were quantitatively determined by appropriate selective and sensitive HPLC assays. The concentration and time profiles revealed that about 40% of the triplet ketones derived from the thermal decomposition of HTMD led to photooxidation of dGuo. Essentially equal amounts of type I and type II photooxidation products were found, as could be established by comparison with predominant type I (benzophenone, riboflavin) and type II (Rose Bengal, methylene blue) photosensitizers. The participation of singlet oxygen (type II activity) was confirmed by the substantial D2O effect in the formation of 8-oxodGuo. The results demonstrate that dioxetanes, particularly HTMD, are efficient photooxidants of dGuo on thermal activation in the dark and constitute excellent chemical tools to study photobiological processes without the use of light, in the present case, photogenotoxicity.
Planar inverted-F antennas as an inverse class-F termination for wireless applications (2003)

We present an electrically small antenna for use with high-efficiency power amplifiers for wireless applications. A planar inverted-F antenna (PIFA) design is shown that is optimized to provide an inverse class-F load termination for use at the output of a field effect transistor (FET) for optimum output power and efficiency. A power-added efficiency in excess of 60% was also measured for an active PIFA.
Chronic Constipation (2003)

Chronic constipation is a common condition that can be debilitating and difficult to treat. This review explains the physiologic processes involved in colonic transit and defecation. The evaluation of patients is summarized along with current strategies for clinical management.
Global flatness of spatial light modulators (2006)

The Fraunhofer Institute for Photonic Microsystems (IPMS) Dresden (Germany) has developed a one megapixel SLM device with 512 x 2048 individually addressable tilting micromirrors optimized for micro-lithography applications. Besides many other chip parameters SLM surface planarities strongly determine the pattern performance on the lithography masks. This paper presents results on the so called Global Flatness (GF) of the chips which takes into account the complete active area of the large mirror matrix. A description and definition of GF is presented, followed by measurement results on GF prior to chip packaging. Different adhesives are tested for the die bonding process. Bonding on flat test substrates enables the separation of different influences on GF. Impacts of the topography of the die attach and of die bonding process parameters on GF are investigated, optimization potentials such as different dispense modes are tested and discussed. Influences of the chip layout on GF are evaluated. A transfer of Global Flatness measurements to other large area optical chips, e. g. image sensors, is outlined. In the future GF improvements are expected to gain importance due to the ever increasing requirements on CD and CD uniformity performance of mask writers.