gebhart/patrepeval huggingface dataset:
Ocular Toxic Effects of Fenretinide (1990)

Journal Article Ocular Toxic Effects of Fenretinide Get access Manuel R. Modiano, Manuel R. Modiano Search for other works by this author on: Oxford Academic PubMed Google Scholar William S. Dalton, William S. Dalton Search for other works by this author on: Oxford Academic PubMed Google Scholar Scott M. Lippman, Scott M. Lippman Search for other works by this author on: Oxford Academic PubMed Google Scholar Leonard Joffe, Leonard Joffe Search for other works by this author on: Oxford Academic PubMed Google Scholar Ann R. Booth, Ann R. Booth Search for other works by this author on: Oxford Academic PubMed Google Scholar Frank L. Meyskens Frank L. Meyskens Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 12, 20 June 1990, Page 1063, https://doi.org/10.1093/jnci/82.12.1063 Published: 20 June 1990 Article history Received: 16 April 1990 Accepted: 17 April 1990 Published: 20 June 1990
Inversion And Folding Shear Interferometers Using Holographic Optical Elements (1987)

In the field of optical testing, the use of shear interferometers has a distinct advantage over other techniques due to the fact that the number of fringes in the interferogram can be controlled by changing the amount of shearl). Many schemes for lateral and radial shear interferometers have been proposed utilizing holo-optics2-4). In this paper, we propose two more schemes for shear interferometers using holographic optical elements.
Clinical and Genetic Characteristics of Calvarial Doughnut Lesions with Bone Fragility in Three Families with a Reccurent SGMS2 Gene Variant (2023)

Calvarial doughnut lesions (CDL) with bone fragility with or without spondylometaphyseal dysplasia (MIM: #126550) is a rare autosomal dominant skeletal disorder characterized by low bone mineral density, spinal and peripheral fractures, and specific sclerotic lesions of the cranial bones. In the current classification of skeletal disorders, the disease is included in the group of bone fragility disorders along with osteogenesis imperfecta. The disease is caused by pathogenic variants in the <i>SGMS2</i> gene, the protein product of which is sphingomyelin synthase 2, which primarily contributes to sphingomyelin (SM) synthesis-the main lipid component of the plasma membrane essential for bone mineralization. To date, 15 patients from eight families with CDL with bone fragility have been described in the literature, and a recurrent variant c.148C>T (p.Arg50Ter) in the <i>SGMS2</i> gene has been identified, which was found in patients from six families. We diagnosed the disease in 11 more patients from three unrelated families, caused by the same heterozygous nonsense variant c.148C>T (p.Arg50Ter) in the <i>SGMS2</i> gene. Our results show wide interfamilial and intrafamilial phenotypic variability in patients with a detected recurrent variant in the <i>SGMS2</i> gene, the presence of which must be taken into consideration in the diagnosis of the disease. The primary analysis of this variant will contribute to optimal molecular genetic diagnostics, which can reduce diagnostic costs and time.
A Chlamydomonas-Derived Human Papillomavirus 16 E7 Vaccine Induces Specific Tumor Protection (2013)

The C. reinhardtii chloroplast is a suitable expression system for the production of the E7GGG protein, in a soluble, immunogenic form. The production in contained and sterile conditions highlights the potential of microalgae as alternative platforms for the production of vaccines for human uses.
Contributions of Stepan V Lomov to the research and development of composite materials (2020)

This paper presents a comprehensive review of the scientific and engineering contributions of Prof. Stepan V. Lomov in a career spanning over 3 decades. Starting from his early work on the modelling of dry textiles, different aspects of composite materials have benefited from his inspiring contribution. His wide scientific curiosity drove the research on several topics, covering permeability, forming, damage, fatigue, nano-engineered composites, as well as development of analytical and numerical models at different scales. The paper presents a full spectrum of his scientific career aiming to link his achievements and the future research on composite materials.
Sleep Quality Associated With Motor Function Among Older Adult Survivors of Critical Illness (2020)

Sleep promotion may be a potentially modifiable risk factor to mitigate ICU-acquired weakness in older ICU survivors. We propose that improving sleep throughout recovery from critical illness may indirectly promote better outcomes, as poor grip strength is linked to longer length of hospital stay, higher acuity of discharge disposition, and worsened functional decline in older adults.
Treatment of genu valgum in children by means of temporary hemiepiphysiodesis using eight-plates: short-term findings (2017)

Temporary hemiepiphysiodesis using eight-Plates is a gentle, simple and effective procedure used to treat genu valgum by modulating growth. Slight overcorrection is desirable due to the rebound phenomenon, especially in young patients with high growth potential and risk groups such as obese children. In adolescents with only low growth potential (older than 14 years), owing to the low correction potential, the indication should be strictly reviewed and the possible failure of therapy should be discussed with the patient. No differences were observed regarding the location of the implanted eight-Plates (femoral or tibial).
Low‐Density Polyethylene High‐Pressure Process (2012)

This chapter contains sections titled: Introduction Reaction Kinetics and Thermodynamics Process Products and Properties Simulation Tools and Advanced Process Control References
Thermal and electrical ignitability of dust clouds. Report of investigations (1983)

The Bureau of Mines conducted a comprehensive laboratory study of the thermal ignitability of various carbonaceous dust clouds with particular emphasis on various ranks of coal dust. The tests were conducted using a new 1.2-L furnace. Autoignition temperatures of dust clouds were obtained as a function of coal volatility and particle size. Dust particles and gas samples were collected by a rapid-sampling system in order to study the reactions involved in preignition and postignition processes. The autoignition temperatures measured in the new 1.2-L furnace were significantly lower and therefore more conservative than those measured previously in the Godbert-Greenwald furnace.
Using cluster-based logic blocks and timing-driven packing to improve FPGA speed and density (1999)

In this papel; we investigate the speed and area-eficiency of FPGAs employing “logic clusters ” containing multiple LUTs and registers as their logic block. We introduce a new, timing-driven tool (T-VPack) to “pack ” LUTs and registers into these logic clusters, and we show that this algorithm is superior to an existing packing algorithm. Then, using a realistic routing architecture and sophisticated delay and area models, we empirically evaluate FPGAs composed of clusters ranging in size from one to twenty LUTs, and show that clusters of size seven through ten provide the best area-delay trade-o @ Compared to circuits implemented in an FPGA composed of size one clusters, circuits implemented in an FPGA with size seven clusters have 30 % less delay (a 43 % increase in speed) and require 8 % less area, and circuits implemented in an FPGA with size ten clusters have 34 % less delay (a 52 % increase in speed), and require no additional area. 1.
Structure-Activity Relationships Amongst β-Lactamase Inhibitors (1986)

Using a variety of beta-lactamases including those from Escherichia coli (TEM-1), Enterobacter cloacae P99 and Staphylococcus aureus the inhibition profiles (I50 values) were determined for various groups of compounds including penicillins, penicillanic acid derivatives (sulphone and beta-halo substitutions), olivanic acids and clavulanic acid derivatives including substituted ethers and amines. Some of the latter compounds had higher activity than clavulanic acid with and without preincubation of enzyme with inhibitor but they still had poor activity against the P99 enzyme. Improvements in activity against Class I cephalosporinases were obtained with some derivatives of clavulanic acid but this was usually achieved at the expense of activity against clavulanate susceptible beta-lactamases. The olivanic acids had the highest activity against the widest range of beta-lactamases.
Several plume flows in pure and saline water at its density extremum (1981)

An accurate representation of the motion-causing buoyancy force, in the vicinity of the maximum-density condition in water at low temperatures, is determined by using a very accurate and quite simple equation of state for both pure and saline water. The resulting general laminar boundary-layer flow equations admit similarity solutions and, in the absence of salinity diffusion, require only one additional new dimensionless variable, called R . For flows of constant heat content in an unstratified ambient fluid, similarity is found only when the far-field temperature is at the temperature of maximum density. The three flow situations considered here are two above a horizontal line heat source and one above a point heat source. The first flow is a freely rising plane plume and the second is a wall plume (flow over a vertical, adiabatic surface with a horizontal line source imbedded in it). The third flow is the freely rising axisymmetric plume. These are the models in laminar theory of many processes which arise in cold water. A primary objective here is to calculate the effect of using a nonlinear density relation for water, which is much more accurate at low temperatures than the conventional linear one used in ‘classical’ analyses. The downstream variations of the temperature and velocity fields are found to be very different from those for flows where the effect of a density extremum is not included.
Sensorless position estimation for switched reluctance motors using artificial neural networks (2000)

This doctoral thesis presents a new approach to the sensorless operation of the Switched Reluctance Motor (SRM). The premise of the method is that an Artificial Neural Network (ANN) forms an efficient mapping structure for the SRM. Through measurement of the phase flux linkages and phase currents the ANN is able to estimate the rotor position. The ANN training data set includes the SRM magnetization characteristic of which flux linkage (λ) and current (i) as inputs and the corresponding position (t) as output. 
The suggested method does not require any SRM model to construct the relation between the electric and mechanic variables. The measurement of these variables is the only requirement. From this point of view, the method can be classified as model-free rotor position estimation scheme. 
The first step in the investigation was the selection of an ANN. Then the preparation of the training data set was studied. After that, an off-line case study was performed. This study showed that the ANN is capable of estimating rotor position by using SRM magnetization data. Before on-line case study, ANN hardware implementation issues and rotor position estimator requirements were worked out. 
At the next step, the possibilities of using the ANN-based estimator in the real time operation of the SRM were examined. For this purpose, first the real time operation of the same 20 kW SRM with shaft encoder was simulated by using Simulink™ and then ANN-based estimator was integrated into the simulation to see the on-line operation performance. Various operating conditions were tested from zero to full speed with a successful start-up sequence. 
The final milestone is to conduct experimental studies. The first task was the collection of the training data while the SRM is running with shaft encoder. The next step was the preprocessing of these data and to train an appropriate ANN. Then the trained ANN was emulated in a Digital Signal Processor (DSP). Finally, real-time data were fed to the DSP-based ANN and stable sensorless operation was achieved for various operating conditions.
ChemInform Abstract: Tandem Aldol—Tishchenko Reactions of Lithium Enolates: A Highly Stereoselective Method for Diol and Triol Synthesis. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans (2019)

A 48-year-old woman with severe pain and numbness of her right leg and foot was admitted to our hospital. She had never smoked and had little exposure to passive smoking. Initially, polyarteritis nodosa with anti-phospholipid antibodies was considered. Combination therapy with methylprednisolone pulse therapy, intravenous cyclophosphamide pulse therapy, vasodilators, antiplatelet agents, and anticoagulants was not effective. Vasculopathy was progressive, and she presented with gangrene of the toes. She required amputation of her right leg. The pathological findings of the amputated leg revealed thromboangiitis obliterans (TAO). TAO should be considered even in non-smoking women. Non-response to immunosuppressant and anticoagulant therapies may be a clue to the diagnosis of TAO.
Cyclin-dependent kinase 6 is the principal target of p27/Kip1 regulation of the G1-phase traverse in 1,25-dihydroxyvitamin D3-treated HL60 cells. (1997)

Control of cell proliferation remains of intense interest in cancer research. In the 1,25-dihydroxyvitamin D3 HL60 cell system, G1 arrest has been shown to be mediated by elevated levels of p27/Kip1 protein. We show here that the main target of the elevated p27/Kip1 in this system is cyclin-dependent kinase (Cdk) 6. The activity of Cdk2 is also down-regulated, and this is associated with altered and reduced levels of cyclin E in the kinase complex. Paradoxically, the kinase activity of Cdk4 is elevated, in spite of an almost complete G1 block. These data show that the functions of Cdk4 and Cdk6 are not redundant and that Cdk6 and Cdk2 activities are regulated by 1,25-dihydroxyvitamin D3.
ANALYSIS OF GAS-PHASE MASS TRANSFER IN TURBULENT FLOWS (thesis) (1964)

diameter and sphericity on the continuous-phase Peclet number was also found. Different mechanisms were indicated for dispersion in the discontinuous phase, depending upon whether or not that phase wets the packing. (auth)
The effect of temperature on single-particle latchup (1991)

Special test structures fabricated with three different CMOS processes were used to investigate the effect of elevated temperature on single-particle latchup. The latchup threshold was strongly affected by contact geometry, and its temperature dependence is consistent with a model based on triggering of the vertical parasitic transistor. Threshold LET values decreased by about a factor of 2.5 at 125 degrees C relative to room temperature values for all three processes. Saturation cross sections exceeded the isolation well area for the two bulk processes because of diffused charge. Laser studies showed that latchup could be triggered by strikes outside the isolation well, consistent with the diffused charge mechanism. These same mechanisms were consistent with measurements of the latchup cross section of a static CMOS RAM.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Studies of granular flow down an inclined chute. Quarterly technical progress report, Year Three, Quarter Three, 13 June 1993--12 September 1993 (1993)

The dynamics of flowing granular material has been previously observed in inclined chutes. One of the questions arising from previous work regards the existence of fully developed, steady flows. Depending upon the friction or bumpiness of the chute base, experiments have indicated that under some conditions the flow appears to be steady and fully developed. While a truly fully developed flow can never be proven to exist in an experimental apparatus because of its finite length, apparent fully developed flows are observed to within reasonable experimental accuracy. The present series of experimental focuses on the existence of steady, fully developed flows over a low friction, bumpy base.
[Demonstration of the pulsatile secretion of LH-RH into hypophysial portal blood of ewes using an original technic for multiple samples]. (1982)

Using a stereotaxic dorsal approach under lateral X-Ray control associated with a perfusion system, serial collections of hypophysial portal blood have been successfully obtained in three spayed ewes during 4 to 9 successive hrs. For the first time, pulsatile patterns of LH-RH secretion have been demonstrated in long term ovariectomized ewes. The frequency of LH-RH pulses recorded (about one pulse every 50 mn) agrees closely with the frequency of LH pulses in peripheral plasma of ovariectomized ewes. The technique allowed measurement of LH-RH in hypophysial portal blood thus providing a useful method for investigation of hypothalamo-pituitary gonadal interactions.
Design of Self-Cross-Linkable Poly(n-butyl acrylate)-co-poly[N-(hydroxymethyl)acrylamide] Amphiphilic Copolymers toward Elastic and Self-Healing Properties (2020)

A huge challenge for developing self-healing materials is achieving a good compromisation between mechanical properties and self-healing efficiency. For this purpose, a facile route by introducing N-(hydroxymethyl)acrylamide (NMA) as a thermal-catalyzed self-cross-linker as well as a self-healing material into a soft polymer system for tuning the mechanical properties in an easy way, resulting in elastic and self-healing properties through a covalent and dynamic network simultaneously, represents an exciting avenue for the development of self-healing materials. Specifically, we propose a simple strategy to synthesize a self-cross-linkable poly{(n-butyl acrylate)-co-[N-(hydroxymethyl)acrylamide]} (PBAx-co-PNMAy) amphiphilic copolymer prepared by radical polymerization method, where x and y are BA and NMA ratios, respectively, based on the monomer composition in the obtained copolymer. The mechanical properties and self-healing efficiency of the copolymer can be easily tuned by controlling the monomer ratios and varying the self-cross-linking reaction conditions. PBA0.8-co-PNMA0.2 in bulk solid state possesses a stretchability of up to 191%, maximum stress of 571 kPa, and a self-healing efficiency of 90% in ambient conditions without any interventions. Owing to the hydrophobic nature of PBA in the copolymer system, self-healing can be triggered even underwater. Furthermore, a microscale thin film bestowed with identical self-healing and mechanical properties can be fabricated and the behavior of the copolymer in thin-film form was inspected using a pseudofreestanding tensile tester machine. This work provides insight into the future design of materials with elastic, self-cross-linking, and self-healing properties, which are adjustable depending on the desired applications.
Serum lipoprotein concentrations and hepatic lesions in obese cats undergoing weight loss (1992)

Serum lipoprotein concentrations, routine serum biochemical values, and morphologic changes of the liver were evaluated in cats undergoing weight loss. Food was withheld from 6 obese and 6 control cats for 3 days (days 0 to 2), followed by feeding 50% of previous food intake for 26 days (days 3 to 28). Percutaneous liver biopsy specimens were obtained from all cats on days 0, 7, 14, and 28. Blood samples for serum biochemical analysis and lipoprotein profiles were obtained on days 0, 3, 7, 14, and 28. All cats lost weight throughout the study, and none developed signs of clinical illness, including those of idiopathic hepatic lipidosis syndrome. Serum total cholesterol concentrations decreased initially in all cats, but rapidly returned to normal after day 3 in obese cats, suggesting altered cholesterol metabolism during dietary restriction. Low-density lipoprotein concentrations decreased throughout the study in control cats, but were unchanged in obese cats. Examination of liver biopsy specimens from each cat revealed minimal lipid accumulation in all specimens, although some specimens contained hydropic degeneration.
Muscle protein analysis. I. High-resolution two-dimensional electrophoresis of skeletal muscle proteins for analysis of small biopsy samples. (1979)

We have been developing a clinically useful method for high-resolution two-dimensional electrophoretic analysis of small (5--10 mg) human muscle biopsy samples with sufficient resolution to resolve the major contractile proteins and enzymes. Using rabbit psoas muscle as a model, we describe methods for sample preparation and two-dimensional electrophoresis. Basic proteins, which appear as streaks when conventional isoelectric focusing is used in the first dimension, are resolved through a modification of the nonequilibrium pH gradient electrophoresis method [Cell 12, 1133 (1977)]. In the two-dimensional patterns obtained from rabbit muscle, we identify the components of 10 enzymes and of myosin, actin, tropomyosin, and troponin. These patterns indicate charge heterogeneity in a large fraction of the proteins. Comparison of rabbit and normal human muscle patterns shows many similarities, but much additional work is required to confirm identifications. We conclude that analysis of small biopsy samples is feasible, but that all aspects of human sample acquisition, storage (when necessary), and preparation require thorough study before the method becomes routine in human muscle research and, ultimately, in the diagnosis of some muscle diseases.
The relevance of murine animal models to study the development of allergic bronchial asthma (1996)

Bronchial asthma (BA) develops on the basis of a genetic predisposition and involves a characteristic sequence of changes in immune functions. In the immunopathogenesis, several phases can be distinguished: the initial stage is defined as the development of allergic sensitization. This step is dependent on: (i) T cell activation; (ii) IL-4 production; (ii) IgE synthesis; and (iv) mediator release by effector cells. The second phase of allergic inflammation as a consequence of the T cell dependent sensitization is characterized by IL-5 production and eosinophil activation and recruitment. Airway mucosa remodelling is the consequence of chronic inflammatory processes and represents the final stage of BA. In this article animal models will be discussed with regard to their relevance for these different phases in development of chronic allergic BA.
Odontoid process fracture osteosynthesis with a direct screw fixation technique in nine consecutive cases (1988)

The authors present their experience with surgical treatment of odontoid process fractures using a direct screw fixation technique via an anterolateral retropharyngeal approach. Nine consecutive patients have been operated on with this technique. There were two deaths unrelated to the surgery, and anatomical union with conservation of the craniospinal hinge mobility was achieved in the remaining seven patients. The direct screw fixation technique appears feasible, efficient, and logical.