gebhart/patrepeval huggingface dataset:
Results of Arthroscopic Labral Reconstruction of the Hip in Elite Athletes (SS‐39) (2012)

Femoracetabular impingement (FAI) has been well characterized as a cause of hip pain and resultant damage to the acetabular labrum. As an understanding of the pathologic process has increased, it has become clear that an intact labrum is essential for normal joint mechanics, hip stability, and preservation of the articular cartilage. The patient with severe damage and an irreparable labrum presents a difficult clinical challenge. To address a labral deficiency, reconstruction has been reported utilizing an arthroscopic technique with iliotibial(IT) band autograft, recreating the appropriate depth and acetabular seal.
Die Addition der Anionen von Acrylsäure und Butadien‐carbonsäure‐(1) (1953)

Abstract Während die Addition von Butadien‐carbonsäure‐(1) an Acrylsäure bei der Verwendung der freien Säuren, ihrer Chloride und ihrer Amide zu Addukten mit orthoständigen Substituenten führt, erhält man bei der Addition der Ionen die ortho ‐ und meta ‐Form zu annähernd gleichen Teilen. Die Anlagerung von Acrylsäure an Anthracen‐carbonsäure‐(9) in Form ihrer Ionen ergibt ein Addukt mit meta ‐ständigen Carboxygruppen als Hauptprodukt.
Simulation for improvement of dynamic path planning in autonomous search and rescue robots (2009)

To hasten the process of saving lives after disasters in urban areas, autonomous robots are being looked to for providing mapping, hazard identification and casualty location. These robots need to maximise time in the field without having to recharge and without reducing productivity. This project aims to improve autonomous robot navigation through allowing comparison of algorithms with various weightings, in conjunction with the ability to vary physical parameters of the robot and other factors such as error thresholds/limits. The lack of a priori terrain data in disaster sites, means that robots have to dynamically create a representation of the terrain from received sensor range-data in order to path plan. To reduce the resources used, the affect of input data on the terrain model is analysed such that some points may be culled. The issues of identifying hazards within these models are considered with respect to the affect on safe navigation.
Carbon nanodots as peroxidase mimetics and their applications to glucose detection (2011)

Carbon nanodots (C-Dots) were found to possess intrinsic peroxidase-like activity, and could catalytically oxidize 3,3',5,5'-tetramethylbenzidine (TMB) by H(2)O(2) to produce a colour reaction. This offers a simple, sensitive and selective colorimetric method for glucose determination in serum.
A novel type of cytoplasmic granule in bovine neutrophils. (1983)

We obtained cell preparations containing greater than 95% neutrophils from freshly drawn bovine blood. The cells were suspended in sucrose and disrupted in a Dounce homogenizer, and the postnuclear supernate was fractionated by zonal differential sedimentation and by isopycnic equilibration. The subcellular fractions were characterized biochemically by testing for marker enzymes and other constituents known to occur in azurophil and specific granules of other species, and by electrophoretic analysis of extracts of the particulate material. In addition, each fraction was examined by random-sampling electron microscopy. We found that bovine neutrophils contain in addition to azurophil and specific granules a third type of granule, not known to occur in neutrophils of other species. These novel granules are larger, denser, and considerably more numerous than the two other types. Except for lactoferrin, they lack the characteristic constituents of azurophil granules (peroxidase, acid hydrolases, and neutral proteinases) and of specific granules (vitamin B12-binding protein). Instead, they contain a group of highly cationic proteins not found in the other granules, and they are the exclusive stores of powerful oxygen-independent bactericidal agents. We studied the fate of the large granules in bovine neutrophils exposed to opsonized particles, the ionophore A 23187, or phorbol myristate acetate. The appearance in the cell-free media of antibacterial activity and of the characteristic highly cationic proteins as revealed by electrophoresis was monitored and compared with the release of azurophil and specific granule markers. In addition, changes of the relative size of the large granule compartment induced by phagocytosis were assessed by morphometry. The results show that exocytosis of the large granules occurs following both phagocytosis and exposure to soluble stimuli. Like the specific granules, the large granules appear to be discharged by true secretion under conditions where the azurophil granules are fully retained.
Effects of Web GIS Technology and Curriculum Approaches on Education for Disaster Risk Reduction (2023)

Abstract. Disaster risk reduction education (DRRE) is a strategy to mitigate the harmful effects of disasters. The implementation of DRRE in schools is on the rise, and Web GIS technology in DRRE is becoming increasingly prevalent. However, little knowledge exists about whether students can improve their understanding of disaster risk reduction (DRR) through Web GIS technology and which factors affect their learning of web hazard maps. This study has provided materials and curricula for DRR education in Chinese and Japanese high schools, and utilized them eight times in the classroom between 2020 and 2022. These classes had three forms of implementation due to the COVID-19 pandemic: online, onsite, and online-onsite mixed. The students first answered a pretest. Then they learned about DRR using the explanatory web pages and the web hazard maps with answering quizzes shown on the pages. After that, they answered a posttest and a questionnaire. Most students show improved results after using the digital DRR materials. It is pronounced for the onsite implementations, whereas the online-onsite mixed implementation was less effective. The pretest scores for the implementations using local disaster cases are low, but the subsequent improvement is significant. The ability of students to utilize electronic devices affects the learning of GIS-related content rather than other aspects. The frequency of daily usage of online maps and daily attention to disaster prevention and mitigation affect learning the entire materials. Increasing the use of online hazard maps is a key to realizing social DRR.
Thermoset Injection Molding (2017)

Thermosetting plastics are distinguished by the fact that they are capable of forming an infusible cross-linked or network structure by an irreversible chemical reaction. As a consequence, thermosets inherently possess excellent mechanical and heat-resistance properties. Their performance characteristics at elevated temperatures are generally superior to those of thermoplastic polymers. Despite these positive attributes, thermosets currently occupy about 18% of the plastics market in the United States [1]. Undoubtedly, difficulties associated with the processability of these materials have limited their penetration in many conventional markets.
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR ANALYSIS OF LERCANIDIPINE IN BULK DRUG AND MICROEMULSION FORMULATION (2012)

A simple, sensitive, and stability indicating method is described for the quantitative determination of lercanidipine both in bulk drugs and microemulsions, also in the presence of its degradation products. The method was based on high-performance liquid chromatographic (HPLC) separation of drug from its degradation products. The analysis was carried out on C18 reverse phase (Agilent TC-C18(2) column (250 mm × 4.6 mm I.D., 5-micron particle size)) in isocratic mode at ambient temperature using separation mobile phase, impelled by binary pump, consisting of acetonitrile (ACN) and disodium hydrogen phosphate (Na2HPO4) buffer, pH 4 (55:45, v/v volume). Flow rate was 1.0 mL min−1 with an average operating pressure of 140 kg cm−2 and tR was found to be 8.3 ± 0.15 min. Quantitation was achieved with UV detection at 240 nm based on peak area with linear calibration curves at concentration range 10–40 µg mL−1. The method was validated for accuracy, precision, reproducibility, specificity, robustness, and detection and quantification limits, in accordance with ICH guidelines. The wide linearity range, sensitivity, accuracy, and simple mobile phase imply the method is suitable for routine quantification of lercanidipine in bulk drugs and microemulsion formulation with high precision and accuracy.
Structural analysis of micro-channels in human temporal bone (2015)

Recently, numerous micro-channels have been discovered in the human temporal bone by micro-CT-scanning. Preliminary structure of these channels has suggested they contain a new separate blood supply for the mucosa of the mastoid air cells, which may have important functional implications. This paper proposes a structural analysis of the microchannels to corroborate this role. A local structure tensor is first estimated. The eigenvalues obtained from the estimated local structure tensor were then used to build probability maps representing planar, tubular, and isotropic tensor types. Each tensor type was assigned a respective RGB color and the full structure tensor was rendered along with the original data. Such structural analysis provides new and relevant information about the micro-channels but also their connections to mastoid air cells. Before carrying a future statistical analysis, a more accurate representation of the micro-channels in terms of local structure tensor analysis using adaptive filtering is needed.
New minimum component electronically tunable OTA-C sinusoidal oscillators (1989)

Two new transconductance-amplifier-capacitor sinusoidal oscillators are introduced. Each circuit requires only two OTAs and two capacitors, the minimum number of components. The circuits can generate linearly tunable variablefrequency oscillations.
Morphine administration during low ovarian hormone stage results in transient over expression of fear memories in females (2015)

Acute exposure to morphine after a traumatic event reduces trauma related symptoms in humans and conditioned fear expression in male rats. We aimed to determine whether acute administration of morphine alters consolidation of fear learning and extinction. Male and female rats in proestrus and metaestrus (high and low ovarian hormones respectively) underwent fear conditioning and received saline or morphine (2.5 mg/kg s.c.). The next day they underwent extinction. Results showed increased freezing during extinction only in the morphine metaestrus group while morphine did not affect males or proestrus females. Recall of extinction was similar on all groups. On a second experiment, a subset of rats conditioned during metaestrus was administered morphine prior to extinction producing no effects. We then measured mu opioid receptor (MOR) expression in the amygdala and periaqueductal gray (PAG) at the end of extinction (day 2). In males and proestrus females, morphine caused an increase in MOR in the amygdala but no in the PAG. In metaestrus females, morphine did not change MOR expression in either structure. These data suggests that ovarian hormones may interact with MORs in the amygdala to transiently alter memory consolidation. Morphine given after trauma to females with low ovarian hormones might increase the recall of fear responses, making recovery harder.
Liquid-chromatographic assay for urinary homovanillic acid, with fluorescent detection. (1981)

We describe a procedure for measuring urinary homovanillic acid by "high-performance" liquid chromatography. The pH of urine samples is adjusted, and they are chromatographed directly on an octyl silica column. The effluent is reacted with a ferricyanide reagent, to convert homovanillic acid to a product that is fluorescent at 420 nm on excitation at 320 nm. The standard curve is linear up to a homovanillic acid concentration of 20 mg/L; the detection limit is 0.3 mg/L. The method is evaluated for precision, recovery, potential interference, and reference values, and compared (r = 0.99) with a published spectrophotometric method. The proposed method is suitable for the routine analysis for homovanillic acid in urine.
NMR and Its Applications to Living Systems. Second Edition By David G. Gadian (Institute of Child Health, London). Oxford University Press:  New York. 1995. viii + 283 pp. $39.95. ISBN 0-19-855281-5. (1996)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewNEXTNMR and Its Applications to Living Systems. Second Edition By David G. Gadian (Institute of Child Health, London). Oxford University Press: New York. 1995. viii + 283 pp. $39.95. ISBN 0-19-855281-5.Robert E. LondonView Author Information National Institute of Environmental Health SciencesCite this: J. Am. Chem. Soc. 1996, 118, 49, 12485Publication Date (Web):December 11, 1996Publication History Published online11 December 1996Published inissue 1 January 1996https://doi.org/10.1021/ja965648jCopyright © 1996 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views269Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (29 KB) Get e-AlertsSUBJECTS:Nuclear magnetic resonance spectroscopy Get e-Alerts
The chemokine interleukin‐8 and the surface activation protein CD69 are markers for Bcr–Abl activity in chronic myeloid leukemia (2008)

We have identified differentially regulated genes in chronic myeloid leukemia (CML) cells upon short treatment with the broad-spectrum Bcr-Abl inhibitor dasatinib. The highly specific Bcr-Abl inhibitor nilotinib caused a very similar gene expression signature, validating the identified differentially regulated genes as a read-out of Bcr-Abl activity and implying that Bcr-Abl is the functionally central target of dasatinib in CML cells. Among the strongest downregulated genes, we have further validated the activation marker CD69 and the chemokine interleukin (IL)-8. Expression of both proteins is upregulated upon Bcr-Abl expression and inhibited by dasatinib and nilotinib. IL-8 may thus be a useful marker for the monitoring of CML inhibitor efficacy and play a potential pathophysiological role in CML.
Supplemental Tables 1 and 2 from Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer (2023)

&lt;p&gt;Table S1: Plasma S1P levels in patients with RCC; Table S2: Table of ASL MRI values.&lt;/p&gt;
Pointing control for the SPIDER balloon-borne telescope (2014)

We present the technology and control methods developed for the pointing system of the Spider experiment. Spider is a balloon-borne polarimeter designed to detect the imprint of primordial gravitational waves in the polarization of the Cosmic Microwave Background radiation. We describe the two main components of the telescope’s azimuth drive: the reaction wheel and the motorized pivot. A 13 kHz PI control loop runs on a digital signal processor, with feedback from fibre optic rate gyroscopes. This system can control azimuthal speed with &lt; 0.02 deg/s RMS error. To control elevation, Spider uses stepper-motor-driven linear actuators to rotate the cryostat, which houses the optical instruments, relative to the outer frame. With the velocity in each axis controlled in this way, higher-level control loops on the onboard flight computers can implement the pointing and scanning observation modes required for the experiment. We have accomplished the non-trivial task of scanning a 5000 lb payload sinusoidally in azimuth at a peak acceleration of 0.8 deg/s<sup>2</sup>, and a peak speed of 6 deg/s. We can do so while reliably achieving sub-arcminute pointing control accuracy.
Recrystallization of CL-20 and HNFX from Solution for Rigorous Control of the Polymorph Type: Part II, Experimental Studies (2006)

The recrystallization of CL-20 and HNFX to form different polymorphs was investigated by employing various experimental analyses, including micro-crystallization under myriad conditions, novel means of crystallization, analysis of polymorphs using powder diffraction, and Rietveld analysis. In the investigation all three groups of solvents: polar protic, non-polar aprotic, and dipolar aprotic solvents were employed. These results are reported in two parts with the experimental results reported here and the mathematical modeling results reported in Part I of this paper. The conventional crystallization techniques included combinations of solvent and anti-solvent system (including high molecular weight polymer melts), combination of solvents, the use of habit modifiers, and seeding. Other recrystallization techniques, which were also investigated included recrystallization under UV, under microwaves, upon freeze drying, upon annealing, in the presence of high molecular weight polymers, and under different hydrodynamic and hence different micro-mixing conditions. As will be seen in Part I of this paper (this issue) our computations suggest (in agreement with earlier studies) that multiple polymorphs with various densities for both CL-20 and HNFX are possible. However, the recrystallization studies reported here revealed only one type of polymorph for HNFX, i.e., the Ci R-3 polymorph. On the other hand, CL-20 gave rise to indeed multiple polymorphs which changed with the crystallization conditions, especially with the solvent/anti-solvent systems utilized. An X-ray based method was used to determine the types of polymorphs and also the percentages of the polymorphs generated upon crystallization. The presence of multiple polymorphs or polymorph impurities in CL-20 may have significant ramifications in the sensitivity and other ultimate properties of energetic grains containing CL-20. On the other hand the existence of only one low-density polymorph for HNFX significantly limits the application areas for HNFX.
Electrochemical Reduction of Iron Oxide Nanoparticles on Mercury (2003)

The electrochemical reduction of well-defined γ-Fe2O3 nanoparticles dispersed and stabilized in aqueous media which are appropriate for electrochemical techniques (analysis and preparation) is studied. A medium, in which metallic iron can be formed and in which iron ions do not precipitate, is examined in detail ([citrate(NH4)3] = 0.01 mol/L, NH4ClO4/NH3 pH = 8.6). Our results clearly show that the differences between nanoparticles and ionic species as starting material do not consist in a simple scaling. At intermediate potentials (−0.4 to −1.2 V/ECS) we show that the nanoparticles can be reduced into FeII, with a fraction of it being free in solution. At more negative potentials (−1.5 to −1.8 V/ECS), nanoparticles are reduced into metallic iron nanoparticles that enter the Hg electrode due to the wetting properties of Hg on iron. There exist strong interactions between the oxide nanoparticles and the electrode, interactions which are shown to be partly of electrostatic nature, that is, depending on the concentration of the supporting electrolyte (NH4ClO4/NH3).
Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model (2022)

E-cadherin deficient SRCCs might gain cell motility through upregulation of MMPs. CXCL12-positive cancer-associated fibroblasts could serve to maintain cancer-cell survival as a niche. MMPs and the CXCL12/CXCR4 axis represent promising candidates as novel therapeutic targets for E-cadherin-deficient SRCC.
ArabidopsisNAPandPIRRegulate Actin-Based Cell Morphogenesis and Multiple Developmental Processes (2004)

The actin cytoskeleton mediates cellular processes through the dynamic regulation of the time, location, and extent of actin polymerization. Actin polymerization is controlled by several types of evolutionarily conserved proteins, including those comprising the ARP2/3 complex. In animal cells ARP2/3 activity is regulated by WAVE complexes that contain WAVE/SCAR proteins, PIR121, Nap125, and other proteins. The activity of the WAVE complex is regulated by Rho-GTPase-mediated signaling that leads to ARP2/3 activation by WAVE/SCAR proteins. We describe in this report Arabidopsis (Arabidopsis thaliana) genes encoding Nap and PIR proteins. Light-grown Atnap-1 and Atpir-1 mutant plants displayed altered leaf, inflorescence, silique, and seed set phenotypes. Dark-grown Atnap-1 and Atpir-1 seedlings also exhibited longer roots, enhanced skotomorphogenesis and Glc responses, and shorter thicker hypocotyls than those of wild type, showing that AtNAP and AtPIR participate in a variety of growth and developmental processes. Mutations in AtNAP and AtPIR caused cell morphology defects in cotyledon pavement cells and trichomes seen in mutants in ARP2/3 subunits and in plants expressing constitutively active Rop2 GTPase. The patterns and levels of actin polymerization observed in Atnap-1 and Atpir-1 mutant trichome cells and epidermal pavement cell morphology is consistent with Arabidopsis NAP and PIR proteins forming a WAVE complex that activates ARP2/3 activity. The multiple growth and developmental phenotypes of Atnap and Atpir mutants reveals these proteins are also required for a wider variety of cellular functions in addition to regulating trichome cell growth.
Audiovisual biofeedback improves image quality and reduces scan time for respiratory-gated 3D MRI (2014)

The purpose of this study was to test the hypothesis that audiovisual (AV) biofeedback can improve image quality and reduce scan time for respiratory-gated 3D thoracic MRI. For five healthy human subjects respiratory motion guidance in MR scans was provided using an AV biofeedback system, utilizing real-time respiratory motion signals. To investigate the improvement of respiratory-gated 3D MR images between free breathing (FB) and AV biofeedback (AV), each subject underwent two imaging sessions. Respiratory-related motion artifacts and imaging time were qualitatively evaluated in addition to the reproducibility of external (abdominal) motion. In the results, 3D MR images in AV biofeedback showed more anatomic information such as a clear distinction of diaphragm, lung lobes and sharper organ boundaries. The scan time was reduced from 401±215 s in FB to 334±94 s in AV (p-value 0.36). The root mean square variation of the displacement and period of the abdominal motion was reduced from 0.4±0.22 cm and 2.8±2.5 s in FB to 0.1±0.15 cm and 0.9±1.3 s in AV (p-value of displacement <0.01 and p-value of period 0.12). This study demonstrated that audiovisual biofeedback improves image quality and reduces scan time for respiratory-gated 3D MRI. These results suggest that AV biofeedback has the potential to be a useful motion management tool in medical imaging and radiation therapy procedures.