gebhart/patrepeval huggingface dataset:
Pulsus paradoxus in ventilated and non-ventilated patients. (2007)

Human physiology changes are often amplified in disease states and may be altered when a patient is mechanically ventilated. Normally, systolic blood pressure is slightly lower during inspiration than expiration due to the change in intrathoracic pressure. Pulsus paradoxus is a phenomenon in which the difference in systolic blood pressure (BP) between inspiration and expiration is more than 10 mmHg. When a patient is mechanically ventilated, the pattern of changes observed in pulsus paradoxus is reversed; that is, the systolic BP is higher during inspiration than expiration. In this article, the airway pressure and respiratory impedance tracings are used to demonstrate the inspiratory and expiratory phase of the respiratory cycle. Then BP can be determined with each respiratory phase. The difference in presentation of pulsus paradoxus in patients who are breathing spontaneously and with mechanical ventilation is described. A case study is also included to illustrate the presentation and treatment of pulsus paradoxus in a mechanically ventilated patient.
Redox-Active Eutectic Electrolyte with Viologen and Ferrocene Derivatives for Flow Batteries (2022)

Nonflammable eutectic solvents show great potential to enhance the concentrations of the redox-active materials and the cell voltages for redox flow batteries (RFBs). Herein, we report a promising redox-active eutectic electrolyte (1.5 M total redox species) with viologen and ferrocene derivatives where both of the redox reactions are reversible with a maximum open-circuit voltage of 1.35 V and an energy density of 15.1 Wh L<sup>-1</sup>, which is relevant to large-scale energy storage. The charge-discharge (from 75 to 25% state of charge) characteristics in a flow cell (0.15 M negolyte and 0.3 M posolyte) showed that it can be cycled with consistent discharge capacity for 12 h (19 cycles), beyond which pressure-driven crossover between the posolyte and negolyte reservoirs leads to capacity decay. This study points to promising new directions toward eutectic electrolyte development for RFBs where we demonstrate increasing the polarity, functionalizing the redox molecules, and separating redox intermediates to prevent undesired side reactions can make improvements in operating cell voltage, energy density, and cyclability.
A systematic review and meta-analysis of nut consumption and incident risk of CVD and all-cause mortality (2015)

Dietary patterns containing nuts are associated with a lower risk of CVD mortality, and increased nut consumption has been shown to have beneficial effects on CVD risk factors including serum lipid levels. Recent studies have reported on the relationship between nut intake and CVD outcomes and mortality. Our objective was to systematically review the literature and quantify associations between nut consumption and CVD outcomes and all-cause mortality. Five electronic databases (through July 2015), previous reviews and bibliographies of qualifying articles were searched. In the twenty included prospective cohort studies (n 467 389), nut consumption was significantly associated with a lower risk of all-cause mortality (ten studies; risk ratio (RR) 0·81; 95 % CI 0·77, 0·85 for highest v. lowest quantile of intake, P het=0·04, I 2=43 %), CVD mortality (five studies; RR 0·73; 95 % CI 0·68, 0·78; P het=0·31, I 2=16 %), all CHD (three studies; RR 0·66; 95 % CI 0·48, 0·91; P het=0·0002, I 2=88 %) and CHD mortality (seven studies; RR 0·70; 95 % CI 0·64, 0·76; P het=0·65, I 2=0 %), as well as a statistically non-significant reduction in the risk of non-fatal CHD (three studies; RR 0·71; 95 % CI 0·49, 1·03; P het=0·03, I 2=72 %) and stroke mortality (three studies; RR 0·83; 95 % CI 0·69, 1·00; P het=0·54, I 2=0 %). No evidence of association was found for total stroke (two studies; RR 1·05; 95 % CI 0·69, 1·61; P het=0·04, I 2=77 %). Data on total CVD and sudden cardiac death were available from one cohort study, and they were significantly inversely associated with nut consumption. In conclusion, we found that higher nut consumption is associated with a lower risk of all-cause mortality, total CVD, CVD mortality, total CHD, CHD mortality and sudden cardiac death.
Lipids in pollen — They are different Molecular and cell biology of lipids (2016)

During evolution, the male gametophyte of Angiosperms has been severely reduced to the pollen grain, consisting of a vegetative cell containing two sperm cells.This vegetative cell has to deliver the sperm cells from the stigma through the style to the ovule. It does so by producing a pollen tube and elongating it to many centimeters in length in some species, requiring vast amounts of fatty acid and membrane lipid synthesis.In order to optimize this polar tip growth, a unique lipid composition in the pollen has evolved. Pollen tubes produce extraplastidial galactolipids and store triacylglycerols in lipid droplets, probably needed as precursors of glycerolipids or for acyl editing. They also possess special sterol and sphingolipid moieties that might together form microdomains in the membranes.The individual lipid classes, the proteins involved in their synthesis as well as the corresponding Arabidopsis knockout mutant phenotypes are discussed in this review. This article is part of a Special Issue entitled: Plant Lipid Biology edited by Kent D. Chapman and Ivo Feussner.
Poisson’s ratio measurement in tungsten thin films combining an x-ray diffractometer with in situ tensile tester (1998)

A direct determination of the Poisson’s ratio in 150 nm polycrystalline tungsten thin films deposited by ion-beam sputtering on Duralumin substrates has been performed by combining x-ray diffraction measurements with in situ traction on the sample. X-ray diffraction experiments using the sin2 ψ method have been done at LURE, the French synchrotron facility (Orsay, France) on a four-circle diffractometer. The method described in this letter allows us to extract in a simple way and with a good precision the Poisson’s ratio of thin films on substrates from the evolution of the sin2 ψ curves as a function of applied strains. In the case of tungsten thin film, the value obtained is close to the bulk material one.
Single‐Atom to Single‐Atom Grafting of Pt1 onto FeN4 Center: Pt1@FeNC Multifunctional Electrocatalyst with Significantly Enhanced Properties (2017)

Abstract Nonprecious metal catalysts (NPMCs) FeNC are promising alternatives to noble metal Pt as the oxygen reduction reaction (ORR) catalysts for proton‐exchange‐membrane fuel cells. Herein, a new modulation strategy is reported to the active moiety FeN 4 via a precise “single‐atom to single‐atom” grafting of a Pt atom onto the Fe center through a bridging oxygen molecule, creating a new active moiety of Pt 1 O 2 Fe 1 N 4 . The modulated FeNC exhibits remarkably improved ORR stabilities in acidic media. Moreover, it shows unexpectedly high catalytic activities toward oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), with overpotentials of 310 mV for OER in alkaline solution and 60 mV for HER in acidic media at a current density of 10 mA cm −2 , outperforming the benchmark RuO 2 and comparable with Pt/C(20%), respectively. The enhanced multifunctional electrocatalytic properties are associated with the newly constructed active moiety Pt 1 O 2 Fe 1 N 4 , which protects Fe sites from harmful species. Density functional theory calculations reveal the synergy in the new active moiety, which promotes the proton adsorption and reduction kinetics. In addition, the grafted Pt 1 O 2  dangling bonds may boost the OER activity. This study paves a new way to improve and extend NPMCs electrocatalytic properties through a precisely single‐atom to single‐atom grafting strategy.
Polymer grafting from a metallo‐centered enzyme improves activity in non‐native environments (2020)

Abstract Metallo‐centered enzymes have found applications in environmental remediation, green synthesis and sensors. These enzymes destabilize at extreme pH, elevated temperature or high‐organic‐content conditions. For these enzymes to find more widespread adoption and use, stabilization in non‐native conditions is critical. We report the impact of grafting polymers from the surface of laccase, a metalloenzyme with a Cu active site, modified with a polymerization‐initiating species ligated to the protein's lysine residues. Initiators for continuous activator regeneration atom transfer radical polymerization was used to graft a small library of polymers from the protein. The impact of polymer grafting on enzyme activity as a function of pH, temperature or organic solvent was determined. While polymer grafting from laccases was found to increase enzymatic activity, we found that grafting high‐molecular‐weight dimethylaminoethyl methacrylate displayed the greatest enhancement to catalytic activity. The results demonstrate that polymer grafting can improve laccase activity in native and non‐native conditions. © 2020 Society of Industrial Chemistry
Supplementary Figure 2 from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence (2023)

&lt;p&gt;PDF file - 54K, Metabolic activity of p95HER2-induced senescent cells&lt;/p&gt;
A bridge for the comparison of resistance with capacitance at frequencies from 200 Hz to 2 kHz (2001)

A bridge for the comparison of resistance with capacitance has been designed and constructed. It is a six-arm generalization of the quad bridge and, while retaining the accuracy of a passive-component bridge, makes extensive use of high-precision amplifiers in both source and detector circuits. It will provide a link between the calculable capacitor and the ac quantum Hall resistance (QHR).
Locality-sensitive hashing for protein classification (2014)

Determination of sequence similarity is a central issue in computational biology, a problem addressed primarily through BLAST, an alignment based heuristic which has underpinned much of the analysis and annotation of the genomic era. Despite their success, alignment-based approaches scale poorly with increasing data set size, and are not robust under structural sequence rearrangements. Successive waves of innovation in sequencing technologies – so-called Next Generation Sequencing (NGS) approaches – have led to an explosion in data availability, challenging existing methods and motivating novel approaches to sequence representation and similarity scoring, including adaptation of existing methods from other domains such as information retrieval. In this work, we investigate locality-sensitive hashing of sequences through binary document signatures, applying the method to a bacterial protein classification task. Here, the goal is to predict the gene family to which a given query protein belongs. Experiments carried out on a pair of small but biologically realistic datasets (the full protein repertoires of families of Chlamydia and Staphylococcus aureus genomes respectively) show that a measure of similarity obtained by locality sensitive hashing gives highly accurate results while offering a number of avenues which will lead to substantial performance improvements over BLAST.
High frequency of prostate antigen‐directed T cells in cancer patients compared to healthy age‐matched individuals (2008)

CD8+ T cells directed against prostate antigen peptides can be found in, or generated from, peripheral blood. This indicates that such T cells could be expanded ex vivo for adoptive transfer to prostate cancer patients.
Bound electronic states in a statically screened electric-dipole potential (1996)

The problem of the minimum value of the dipole moment needed to assure the existence of a bound electronic state has been addressed for the electrostatically screened Coulomb interaction of the Yukawa type. Our variational calculation demonstrates that the value of the minimum dipole moment increases as the screening parameter increases. More interestingly, we have found that the dipole's length has a remarkable effect on the minimum dipole moment; a feature not found for the unscreened case. This effect yields a rapid increase of the value of the minimum dipole moment, particularly for large values of the screening parameter, with the increasing dipole moment's length. \textcopyright{} 1996 The American Physical Society.
Monitoring and diagnosing process control performance: the single-loop case (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMonitoring and diagnosing process control performance: the single-loop caseNives Stanfelj, Thomas E. Marlin, and John F. MacGregorCite this: Ind. Eng. Chem. Res. 1993, 32, 2, 301–314Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/ie00014a009https://doi.org/10.1021/ie00014a009research-articleACS PublicationsRequest reuse permissionsArticle Views604Altmetric-Citations131LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nutritional and pharmacological importance of Ficus carica - A review (2017)

Ficus carica contained alkaloids, tannins, glycosides, flavanoids, saponins, coumarins, sterols, terpenes carbohydrates, phenols, essential oil, volatile oil, proteins and minerals.The previous pharmacological studies revealed that Ficus carica possessed antibacterial, antiviral,
Genetic Reduction or Negative Modulation of mGlu7 Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome (2017)

Rett syndrome and MECP2 Duplication syndrome are neurodevelopmental disorders attributed to loss-of-function mutations in, or duplication of, the gene encoding methyl-CpG-binding protein 2 (MeCP2), respectively. We recently reported decreased expression and function of the metabotropic glutamate receptor 7 (mGlu<sub>7</sub>) in a mouse model of Rett syndrome. Positive allosteric modulation of mGlu<sub>7</sub> activity was sufficient to improve several disease phenotypes including cognition. Here, we tested the hypothesis that mGlu<sub>7</sub> expression would be reciprocally regulated in a mouse model of MECP2 Duplication syndrome, such that negative modulation of mGlu<sub>7</sub> activity would exert therapeutic benefit. To the contrary, we report that mGlu<sub>7</sub> is not functionally increased in mice overexpressing MeCP2 and that neither genetic nor pharmacological reduction of mGlu<sub>7</sub> activity impacts phenotypes that are antiparallel to those observed in Rett syndrome model mice. These data expand our understanding of how mGlu<sub>7</sub> expression and function is affected by changes in MeCP2 dosage and have important implications for the therapeutic development of mGlu<sub>7</sub> modulators.
Loss of heterozygosity on 17p in human breast carcinomas: defining the smallest common region of deletion (1990)

The marker D17S5, mapping to the short arm of chromosome 17, was recently reported by us and others to undergo frequent heterozygous deletion in human primary breast carcinomas, implicating the presence of a tumor suppressor gene in this region. To narrow down the location of this gene more precisely, we have performed a deletion-mapping study in an extended series of 78 breast carcinomas, using nine polymorphic markers for the short arm and two polymorphic markers for the long arm of chromosome 17. Partial allele losses on 17p were observed in nine cases, which, taken together, suggest that the target gene for the deletions maps to the region extending between the markers D17S5 (17p13.3) and D17S67 (17p12).
Lack of cross-desensitization between leptin and prolactin signaling pathways despite the induction of suppressor of cytokine signaling 3 and PTP-1B (2007)

Hyperprolactinemia and hyperleptinemia occur during gestation and lactation with marked hyperphagia associated with leptin resistance. Prolactin (PRL) induces the expression of orexigenic neuropeptide Y (NPY) through the activation of JAK-2/STAT-3 signaling pathway in hypothalamic paraventricular nucleus (PVN) leading to hyperphagia. PRL may also act through the inhibition of anorexigenic effect of leptin via induction of suppressor of cytokine signaling 3 (SOCS-3). This paper aimed to co-localize PRL (PRL-R) and leptin (ObRb) receptors in the hypothalamus of female rats and investigate the possible cross-desensitization between PRL-R and ObRb. We showed that: 1) PRL-R and ObRb are expressed in the PVN and co-localized in the same neurons; 2) in lactating females leptin failed to activate JAK-2/STAT-3 signaling pathway; 3) in Chinese Hamster Ovary (CHO) stably co-expressing PRL-R and ObRb, overexposure to PRL did not affect leptin signaling but totally abolished PRL-dependent STAT-5 phosphorylation. The overexposure to leptin produces similar results with strong alteration of leptin-dependent STAT-3 phosphorylation, whereas PRL-dependent STAT-5 was not affected; and 4) CHO-ObRb/PRL-R cells overexposure to leptin or PRL induces the expression of negative regulators SOCS-3 and PTP-1B. Thus, we conclude that these negative regulators affect specifically the inducer signaling pathway; for instance, SOCS-3 induced by PRL will affect PRL-R signaling but not ObRb signaling and vice versa. Finally, the lack of cross-desensitization between PURL-R and ObRb suggests that hyperphagia observed during gestation and lactation may be attributed to a direct effect of PRL on NPYexpression, and is most likely exacerbated by the physiological leptin resistance state.
Desenvolvimento de um software de Monte Carlo para transporte de fótons em estruturas de voxels usando unidades de processamento gráfico (2014)

Sendo o mtodo mais preciso para estimar a dose absorvida em radioterapia, o Mtodo de Monte Carlo (MMC) tem sido amplamente utilizado no planejamento de tratamento radioterpico. No entanto, a sua eficincia pode ser melhorada para aplicaes clnicas de rotina. Nesta dissertao apresentado o cdigo CUBMC, um cdigo de Monte Carlo que simula o transporte de ftons para clculo de dose, desenvolvido na plataforma CUDA (Compute Unified Device Architecture). A simulao de eventos fsicos baseada no algoritmo presente no cdigo PENELOPE, e as tabelas de seo de choque utilizadas so geradas pela rotina MATERIAL, tambm presente no cdigo PENELOPE. Os ftons so transportados em objetos simuladores descritos por voxels. Existem duas abordagens distintas utilizadas para a simulao. A primeira delas obriga o fton a realizar uma parada toda vez que cruza a fronteira de um voxel, a segunda pelo Mtodo de Woodcock, onde o fton ignora a existncia de fronteiras e transportado em um meio homogneo fictcio. O cdigo CUBMC tem como objetivo ser uma opo de cdigo simulador que, ao utilizar a capacidade de processamento paralelo de unidades de processamento grfico (GPU), apresente alto desempenho em mquinas compactas e de baixo custo, podendo assim ser aplicado em casos clnicos e incorporado a sistemas de planejamento de tratamento em radioterapia.
Indicators of Information and Communication Technology (2018)

Information and communication technology (ICT) has become a major driver of changes in economic, social, public, and private life, leading to emergence of the information society and digital economy. Identification of key trends and analysis of transformation processes can only be made on the basis of reliable statistical data. Development of relevant international statistics plays a leading role here; hence, via establishing and updating relevant standards, it allows to measure development of the information society in a global scale, and benchmark positions of individual countries in the worldwide economic environment. ICT indicators are based on general (definitions and classifications, similar data collection methodologies) and specialized statistical standards, whereas harmonized methodology provides highly compatible indicators for different countries. The objective of this chapter is to present a systemic overview of internationally accepted definitions of main ICT indicators based on accumulated methodological standards and practical experience.
ESP Well Surveillance using Pattern Recognition Analysis, Oil Wells, Petroleum Development Oman (2014)

Abstract PDO is managing some 850 Electrical Submersible Pump (ESP) systems scattered across North &amp; South fields, which is continue to grow in the next five years business plan. All ESP wells have real time down-hole sensors that measures intake and discharge pressures, intake and motor temperatures, vibration and current leakage. The oil producing fields are equipped with real time data transmission system where several data measurements; down hole (such as pump intake and discharge pressures and temperatures) and surface (such as volts, amps and frequency) are transmitted directly from the well site to the gathering stations, central control rooms and even to the engineers' desktop. At present, PDO is deploying an integrated smart tool which will monitor, control, and optimize oil production and ESP performance to the various disciplines involved in oil production and optimization like Reservoir and Petroleum Engineers, Programmers, and Field Operation Teams. However, in order to enable these modern well surveillance systems, which often produce an overwhelming quantity of information but the data is often misleading or difficult to interpret, establishing the Pattern recognition of the trended real time data is key to make the software intelligent enough to be effective to the work places. This paper will demonstrate how precise ESP, well and reservoir performance can be predicted from simple physical relationships and how these relate to the trends of surface and downhole data. A number of real field examples of data trends will be shown to illustrate how a proper understanding of these patterns will allow prompt ESP troubleshooting and ensure the correct actions are taken. The results are correlated with equipment pull and inspection reports to validate the diagnosis. Pattern recognition trends and analysis will be presented for common problems such as hole in tubing, shut in at surface, ESP wear, blockage at pump intake, debris in pump, broken shaft, change in reservoir pressure, blockage at perforations, etc. A proper understanding of these trends will allow the correct settings of alarm and trips and assist in the implementation of semi-automated well surveillance and diagnostic system which being currently deployed in the Company. A pattern recognition analysis check sheet will be included in the paper to allow users to quickly interpret data trends and diagnose well, ESP and reservoir performance problems.