gebhart/patrepeval huggingface dataset:
Complement inhibitors to treat IgM-mediated autoimmune hemolysis (2015)

Complement activation in autoimmune hemolytic anemia may exacerbate extravascular hemolysis and may occasionally result in intravascular hemolysis. IgM autoantibodies as characteristically found in cold autoantibody autoimmune hemolytic anemia, in cold agglutinin disease but also in a considerable percentage of patients with warm autoantibodies are very likely to activate complement in vivo. Therapy of IgM-mediated autoimmune hemolytic anemia mainly aims to decrease autoantibody production. However, most of these treatments require time to become effective and will not stop immediate ongoing complement-mediated hemolysis nor prevent hemolysis of transfused red blood cells. Therefore pharmacological inhibition of the complement system might be a suitable approach to halt or at least attenuate ongoing hemolysis and improve the recovery of red blood cell transfusion in autoimmune hemolytic anemia. In recent years, several complement inhibitors have become available in the clinic, some of them with proven efficacy in autoimmune hemolytic anemia. In the present review, we give a short introduction on the pathogenesis of autoimmune hemolytic anemia, followed by an overview on the complement system with a special focus on its regulation. Finally, we will discuss complement inhibitors with regard to their potential efficacy to halt or attenuate hemolysis in complement-mediated autoimmune hemolytic anemia.
The use of program profiling for software maintenance with applications to the year 2000 problem (1997)

VLSC
Attenuation of 7 GHz surface acoustic waves on silicon (2016)

We measured the attenuation of GHz frequency surface acoustic waves (SAWs) on the Si (001) surface using an optical pump-probe technique at temperatures between 300 and 600 K. SAWs are generated and detected by a 700 nm Al grating fabricated by nanoimprint lithography. The grating for SAW generation is separated from the grating for SAW detection by $\ensuremath{\approx}150\phantom{\rule{4pt}{0ex}}\ensuremath{\mu}\mathrm{m}$. The amplitude of SAWs is attenuated by coupling to bulk waves created by the Al grating, diffraction due to the finite size of the source, and the intrinsic relaxational Akhiezer damping of elastic waves in Si. Thermal phonon relaxation time and Gr\"uneisen parameters are fitted using temperature-dependent measurement. The $fQ$ product of a hypothetical micromechanical oscillator limited by Akhiezer damping at this frequency is $\ensuremath{\sim}3\ifmmode\times\else\texttimes\fi{}{10}^{13}$ Hz.
A quantitative analysis of the interactions of antipneumococcal antibody and complement in experimental pneumococcal bacteremia. (1982)

The mechanism of protection of type-specific antipneumococcal antibody and complement in bacteremia was investigated with purified rabbit antibody and a guinea pig model of pneumococcal bacteremia. IgG and IgM were isolated from the sera of rabbits immunized with type 7 pneumococci (Pn), and their binding to Pn was quantitated. The number of antibody-binding sites on the pnuemococcal capsule was also determined. Pn were incubated with various amounts of the immunoglobulin preparations before intravenous injection into nonimmune guinea pigs. Whereas 120 molecules of IgM per Pn were sufficient to enhance bloodstream clearance of Pn, 1,400 molecules of IgG per bacterium were required to produce this effect. As the amount of either IgG or IgM added to the Pn was increased, the rate of bloodstream clearance accelerated. In striking contrast, greater than 1,000 molecules of IgM had no effect on the rate of clearance in C4-deficient guinea pigs, which cannot activate complement via the classic pathway. Similarly, 5,000 molecules of IgG had only minimal effect in C4-deficient guinea pigs, and 24,000 molecules of IgG had no effect in guinea pigs depleted of complement by cobra venom factor. Thus, the in vivo opsonic effects of both IgG and IgM anticapsular antibody are mediated via their ability to activate complement. IgG anti-pneumococcal cell wall antibody, raised by intravenous injection of rabbits with unencapsulated Pn, had no effect on the rate of bloodstream clearance of Pn or on the polymorphonuclear leukocyte killing of type 7 Pn in an in vitro bacterial assay. Because the opsonic effects of anticapsular antibody required complement activation, the ability of anticell wall IgG to activate complement was compared with the two classes of anticapsular antibody. As judged by depletion of C3 and C4 from guinea pig serum, as well as by the fixation of radiolabeled C3 to Pn, IgM anticapsular antibody was the best complement activator. However, anticell wall IgG was somewhat more active than anticapsular IgG in each of these tests of complement activation and fixation. When equivalent amounts of C3 were fixed to Pn by each of the three antibodies, Pn sensitized with IgG and IgM anticapsular antibodies caused immune adherence, whereas Pn sensitized with anticell wall IgG did not. This may explain the failure of anticell wall antibody of mediate complement-dependent phagocytosis of Pn in vivo or in vitro. Although anticell wall IgG is capable of activating complement and fixing C3 to Pn, it is not opsonic; the most likely reason is that the nonopsonic antibody mediates C3 deposition in sites on the Pn that cannot interact efficiently with phagocytic cell C3 receptors.
Nonmonotone Spectral Projected Gradient Methods on Convex Sets (2000)

Made available in DSpace on 2014-12-02T16:28:41Z (GMT). No. of bitstreams: 1 WOS000088375800015.pdf: 195671 bytes, checksum: 26690d43a89cfd1bd72cfca92db356bb (MD5) Previous issue date: 2000
Silicon-germanium carbon alloy (2002)

1. Band Alignments and Band Gaps in Si 1-x-yGexCy/Si (001) Structures 2. Synthesis and Characterization of Compounds and Alloys in the Ge-C, Si-C, and Si-Ge-C Systems 3. Substitutional Carbon Incorporation and Electronic Characterization of Si1-ycy and Si1-x-yGexCy/Si Heterojunctions 4. Electron Transport in Surface-Channel Strained-Si Mosfets and Modulation-Doped Fets 5. The Effects of Carbon on the Optical and Structural Properties of SiGeC Alloys 6. Microstructure and Electronic Structure of Strain-Relaxed SiGe Films 7. Monte-Carlo Investigations of Group-IV Alloys Containing Carbon 8. Theory of Strain and Electronic Structure of Si1-yCy and Si1-x-yGexCy Alloys 9. Microstructural Development and Raman Studies of Ge-C and Ge-Si-C Alloys Grown by Molecular Beam Epitaxy on Si and Ge Substrates 10. Suppression of Boron Diffusion by Carbon: A New Route for Advanced Heterojunction Bipolar Transistors 11. Raman Characterization of Si/Si1-xGex Epitaxial Structures 12. Optical Properties and Band Structure of Unstrained and Strained Si1-xGex and Si1-x-yGexCy Alloys 13. Photoluminescence and Transport Measurements in Pseudomorphic Si1-yCy and Si1-x-yGeyCy Layers 14. Temperature Dependence of the Optical Spectra of Si1-xGex Alloys
Does Osteoarthritis Of The Knee Also Have A Psychogenic Component? Psycho-emotional Treatment With a Radio-electric Device vs. Intra-articular Injection Of Sodium Hyaluronate: An Open-label, Naturalistic Study (2010)

This study is to compare, in patients suffering of knee joint disorder, the effects of intra-articular injection of Sodium Hyaluronate, and those of a treatment aiming at the improvement of the emotional status carried out by means of a Radio Electric Device (REAC). 30 subjects were divided into two groups: 15 who preferred a non-drugs approach (Group A) and 15 who preferred an infiltrative treatment (Group B). The evaluations were expressed for both pain level and knee bending and extension. Group A showed significant decrease in pain, stiffness, joint noises and intra-articular effusion, and significant improvement in motion range, without any patients worsening. 8 patients showed complete disappearance of pain in Visual Analog Pain Scale (VAS) evaluation, evident by a level of 0. The initial VAS results were between 8 and 4. One month after treatment's end, VAS results of the patients in Group A were between 3 and 0. Group B showed significant decrease in pain, stiffness, joint noises and intra-articular effusion, but no significant improvement in motion range; 2 of 15 patients showed worsening symptoms and no significant improvement in muscular hypotrophy. Initial VAS results were between 7 and 4. One month after treatment's end, VAS results were between 6 and 0.
ChemInform Abstract: MOFs as Nano‐Reactors (2014)

Abstract Review: 167 refs.
Cellular Biomechanic Impairment in Cardiomyocytes Carrying the Progeria Mutation: An Atomic Force Microscopy Investigation (2022)

Given the clinical effect of progeria syndrome, understanding the cell mechanical behavior of this pathology could benefit the patient's treatment. Progeria patients show a point mutation in the lamin A/C gene (LMNA), which could change the cell's biomechanical properties. This paper reports a mechano-dynamic analysis of a progeria mutation (c.1824 C > T, p.Gly608Gly) in neonatal rat ventricular myocytes (NRVMs) using cell indentation by atomic force microscopy to measure alterations in beating force, frequency, and contractile amplitude of selected cells within cell clusters. Furthermore, we examined the beating rate variability using a time-domain method that produces a Poincaré plot because beat-to-beat changes can shed light on the causes of arrhythmias. Our data have been further related to our cell phenotype findings, using immunofluorescence and calcium transient analysis, showing that mutant NRVMs display changes in both beating force and frequency. These changes were associated with a decreased gap junction localization (Connexin 43) in the mutant NRVMs even in the presence of a stable cytoskeletal structure (microtubules and actin filaments) when compared with controls (wild type and non-treated cells). These data emphasize the kindred between nucleoskeleton (LMNA), cytoskeleton, and the sarcolemmal structures in NRVM with the progeria Gly608Gly mutation, prompting future mechanistic and therapeutic investigations.
ChemInform Abstract: Di‐, Tri‐, Tetra‐, and Pentacationic Alkylammonium Salts. Ligands Designed to Prevent the Nonspecific Electrostatic Precipitation of Polyanionic, Functionalized Cyclopentadienyltitanium‐Substituted Heteropolytungstate Electron Microscopy Labels with Cationic Biomolecules. (1987)

Abstract The polycationic alkylammonium salts mentioned in the title are prepared by coupling polyamines with oligoether‐substituted oxiranes and subsequent quaternization with methyl iodide.
Experiences Deploying a Transparent Split TCP Middlebox and the Implications for NFV (2015)

This paper summarizes our experiences deploying a transparent Split TCP middlebox for WiFi networks in Enterprise customer environments. Since Split TCP is nearly two decades old, we believed this would be a straightforward application of well-known technology. Reality, however, would teach us otherwise. While we began our deployment in our own office with 3,000 users, we encountered several challenges in deploying this technology at customer sites. Each customer had different network architectures, security policies, and non-negotiable requirements. In particular, modifying the network architecture was frequently impossible. Deployment challenges tended to fall into two related but distinct categories. First, making the box transparent to both clients and servers required extending the notion of transparency from beyond just layer 3 and layer 4 to include layer 2. Second, the interaction of our middlebox with other middleboxes resulted in unexpected behaviors.
Alterations of Phospholamban Function Can Exhibit Cardiotoxic Effects Independent of Excessive Sarcoplasmic Reticulum Ca 2+ -ATPase Inhibition (2009)

The data demonstrate an association between the dose-dependent inhibition of SERCA2a activity by PLN(wt) and the time of onset of heart failure and show that a weak inhibitor of SERCA2a, PLN(R9C), which is diminished in its ability to modify the level of SERCA2a activity, leads to heart failure despite fast sarcoplasmic reticulum Ca(2+) reuptake.
Diel bioluminescence in heterotrophic and photosynthetic marine dinoflagellates in an Arctic fjord (1992)

Oceanic and coastal bioluminescence in surface waters, in many instances, is produced by microscopic dinoflagellates. Their light emission is usually observed at a maximum during the night hours and markedly inhibited during the day. This diel periodicity has never been observed in situ for identified species and never before in heterotrophic Protoperidinium dinoflagellates. Pronounced differences in stimulable bioluminescence measured with bathyphotometers in Vestfjord, Norway in September 1990 correlated with simultaneous ship-board laboratory experiments. Cells of both the photosynthetic Ceratium fusus and heterotrophic Protoperidinium curtipes showed a pronounced inhibition of bioluminescence during the day and maximum bioluminescence at night.
Human herpesvirus multiplex ddPCR detection in brain tissue from low- and high-grade astrocytoma cases and controls (2016)

The undetectable CMV DNA in the astrocytoma cohort does not support the observation of an increased prevalence of CMV DNA in GBM, as reported in other studies. EBV has a significantly higher positivity in the GBM cohort compared to the controls, while HHV-6B has a higher but not statistically significant positivity in the case cohort. Whether these viruses play an oncogenic role in GBM remains to be further investigated.
Editors' Issue 2014 (2014)

As was the case for the previous biennial FENS Fora in Amsterdam and Barcelona, EJN contributes to the celebration of the 2014 FENS Forum in Milan with a Special Issue. The articles in this Special Issue represent the research of the editors. We assembled this issue for the following reasons. EJN prides itself on providing rapid, detailed and fair reviewing. This goal can only be achieved with the support of committed and engaged editors. The associate editors play a key role in this process, and their expertise is often determinant in helping authors to identify weaknesses in their manuscripts and improve them upon revision. How better to demonstrate the commitment of the editors to EJN than by publishing our own research in EJN? The contributions include reviews as well as original investigations and they address the full range of the neurosciences, from molecular and cellular mechanisms to systems, behavioral and cognitive neuroscience. Indeed, the articles in this issue represent the intellectual diversity and richness of our science. The FENS Forum is the appropriate occasion for the editors to demonstrate their commitment to their journal. We hope you will join our enthusiasm for EJN and that you will contribute to the further growth of EJN.
Cervical Disc Arthroplasty vs Anterior Cervical Discectomy and Fusion at 10 Years: Results From a Prospective, Randomized Clinical Trial at 3 Sites (2023)

<h3>Background</h3> Over the past 20 years, multiple randomized controlled trials have shown cervical disc arthroplasty (CDA) to be safe and effective for treating 1- and 2-level degenerative disc disease (DDD). The purpose of this postmarket study is to compare 10-year outcomes between CDA and anterior cervical discectomy and fusion (ACDF) from a randomized study at 3 centers. <h3>Methods</h3> This study was a continuation of a randomized, prospective, multicenter clinical trial comparing CDA with the Mobi-C cervical disc (Zimmer Biomet) vs ACDF. Following completion of the 7-year US Food and Drug Administration study, 10-year follow-up was obtained from consenting patients at 3 high-enrolling centers. The clinical and radiographic endpoints collected at 10 years included composite success, Neck Disability Index, neck and arm pain, short form-12, patient satisfaction, adjacent-segment pathology, major complications, and subsequent surgery. <h3>Results</h3> A total of 155 patients were enrolled (105 CDA; 50 ACDF). Follow-up was obtained from 78.1% of patients eligible after 7 years. At 10 years, CDA demonstrated superiority to ACDF. Composite success was 62.4% in CDA and 22.2% in ACDF (<i>P</i> &lt; 0.0001). The cumulative risk of subsequent surgery at 10 years was 7.2% vs 25.5% (<i>P</i> = .001), and the risk of adjacent-level surgery was 3.1% vs 20.5% (<i>P</i> = .0005) in CDA vs ACDF, respectively. The progression to radiographically significant adjacent-segment pathology at 10 years was lower in CDA vs ACDF (12.9% vs 39.3%; <i>P</i> = 0.006). At 10 years, patient-reported outcomes and change from baseline were generally better in CDA patients. A higher percentage of CDA patients reported they were “very satisfied” at 10 years (98.7% vs 88.9%; <i>P</i> = 0.05). <h3>Conclusions</h3> In this postmarket study, CDA was superior to ACDF for treating symptomatic cervical DDD. CDA was statistically superior to ACDF for clinical success, subsequent surgery, and neurologic success. Results through 10 years demonstrate that CDA continues to be a safe and effective surgical alternative to fusion. <h3>Clinical Relevance</h3> The results of this study support the long-term safety and effectiveness of cervical disc arthroplasty with the Mobi-C. <h3>Level of Evidence</h3> 1.
Low-cost MIMO real-time demonstrator: concept and first results (2005)

In our work, we would like to gain experience on real-world problems of MIMO transmission (e.g., antenna coupling, effects of analog/digital filter accuracy, power consumption, timing, DC offset, channel estimation, TX/RX processing requirements) with a hardware demonstrator as simple as possible. In addition to a quick design and implementation, low overall size is a major goal. To achieve both, we use existing small and low-cost GSM/EDGE modules for the MIMO transmitter and receiver. This paper summarizes the system parameters (e.g., channel bandwidth) as well as the hardware implementation details (e.g., a flexible antenna array setup). It presents MIMO performance measures obtained with the demonstrator (when used as channel sounder) in conjunction with offline MIMO RX processing. In a later stage (not part of this first publication), real-time processing will be implemented (on FPGA and/or DSP), both for open-loop (e.g., STBC, LDC, BLAST) and closed-loop MIMO transmission (i.e., for both long-term and instantaneous channel knowledge at the transmitter). Although somewhat limited due to the narrow GSM/EDGE-like channel bandwidth of about 200 kHz, the results obtained and experience gained with this MIMO demonstrator can be largely applied or scaled to B3G/4G and next-generation WLANs of much wider bandwidth, in particular when based on OFDM (with each subcarrier treated as flat fading).
Using Cone and Plate(let) Analyzer to Predict Bleeding in Cardiac Surgery (2006)

The cone and plate(let) analyzer is an established method for assessing platelet function. It evaluates adherence of platelets on an extracellular matrix, expressed as a percentage of surface coverage and the average size of the aggregates. The purpose of this study was to determine the applicability of the cone and plate(let) analyzer in monitoring platelet function and predicting postoperative bleeding. The relationship between postoperative bleeding, perioperative platelet function, and other parameters was studied. A significant decrease in surface coverage was detected upon establishment of cardiopulmonary bypass (from 6.9% +/- 3.9% to 4.7% +/- 1.7%) with a return to preoperative values at the end of surgery. Preoperative average size and surface coverage were the only parameters that significantly and linearly correlated with postoperative bleeding. Patients with an aggregate average size < 20 microm(2) had a significantly higher incidence of severe bleeding (> 965 mL) than those with a size > 20 microm(2) (44% vs. 0%), and a higher mean blood loss (908 +/- 322 mL vs. 337 +/- 78 mL). Similar results were obtained for surface coverage < 5%, indicating the predictive value of these parameters. Preoperative platelet function as evaluated by the cone and plate(let) analyzer is an independent risk factor determining postoperative bleeding.
Changes in Self-Regulation-Related Prefrontal Activities in Eating Disorders: A Near Infrared Spectroscopy Study (2013)

The decreased cognitive abilities and characteristic prefrontal activation patterns associated with self-regulatory functions were shown in patients with bulimia nervosa, which correlated with their symptoms. These findings suggest inefficient prefrontal self-regulatory function of bulimia nervosa that associate with its symptoms.
A Neural Excitability Based Coding Strategy for Cochlear Implants (2018)

A novel cochlear implant coding strategy based on the neural excitability has been developed and implemented using Matlab/Simulink. Unlike present day coding strategies, the Excitability Controlled Coding (ECC) strategy uses a model of the excitability state of the target neural population to determine its stimulus selection, with the aim of more efficient stimulation as well as reduced channel interaction. Central to the ECC algorithm is an excitability state model, which takes into account the supposed refractory behaviour of the stimulated neural populations. The excitability state, used to weight the input signal for selecting the stimuli, is estimated and updated after the presentation of each stimulus, and used iteratively in selecting the next stimulus. Additionally, ECC regulates the frequency of stimulation on a given channel as a function of the corresponding input stimulus intensity. Details of the model, implementation and results of benchtop plus subjective tests are presented and discussed. Compared to the Advanced Combination Encoder (ACE) strategy, ECC produces a better spectral representation of an input signal, and can potentially reduce channel interactions. Pilot test results from 4 CI recipients suggest that ECC may have some advantage over ACE for complex situations such as speech in noise, possibly due to ECC’s ability to present more of the input spectral contents compared to ACE, which is restricted to a fixed number of maxima. The ECC strategy represents a neuro-physiological approach that could potentially improve the perception of more complex sound patterns with cochlear implants.
ACID Encountering the CAP Theorem: Two Bank Case Studies (2015)

In the era of big data, we may adopt the distributed architecture for a transaction processing system due to some reasons, including distributed branches, heavy demand and operational expenditure, etc. In terms of the CAP Theorem, a transaction processing system associated with ACID properties is infeasible to work well in the distributed architecture. It is indispensable to address how to make a trade-off between availability and partition tolerance for a bank as it favors the consistency in the distributed system. In this research, we conduct two case studies to address the question using two transaction logs collected from a bank in China. We mainly analyze the table dependency and the table concurrency, and find that (1) it is arduous to partition the data in the database system associated with ACID properties, (2) in-memory architecture for updating transactions may be an alternative for building a transaction processing system.
A Survey of Congestion Control Techniques and Data Link Protocols in Satellite Networks (1998)

Satellite communication systems are the means of realizing a global broadband integrated services digital network. Due to the statistical nature of the integrated services traffic, the resulting rate fluctuations and burstiness render congestion control a complicated, yet indispensable function. The long propagation delay of the earth-satellite link further imposes severe demands and constraints on the congestion control schemes, as well as the media access control techniques and retransmission protocols that can be employed in a satellite network. The problems in designing satellite network protocols, as well as some of the solutions proposed to tackle these problems, will be the primary focus of this survey.