gebhart/patrepeval huggingface dataset:
Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Reduces Microglial and Astroglial Inflammatory Responses (2009)

Upon activation, microglia and astrocytes produce a number of proinflammatory molecules that participate in the pathophysiology of several neurodegenerative disorders. This study explores the anti-inflammatory property of cinnamon metabolite sodium benzoate (NaB) in microglia and astrocytes. NaB, but not sodium formate, was found to inhibit LPS-induced expression of inducible NO synthase (iNOS), proinflammatory cytokines (TNF-alpha and IL-1beta) and surface markers (CD11b, CD11c, and CD68) in mouse microglia. Similarly, NaB also inhibited fibrillar amyloid beta (Abeta)-, prion peptide-, double-stranded RNA (polyinosinic-polycytidylic acid)-, HIV-1 Tat-, 1-methyl-4-phenylpyridinium(+)-, IL-1beta-, and IL-12 p40(2)-induced microglial expression of iNOS. In addition to microglia, NaB also suppressed the expression of iNOS in mouse peritoneal macrophages and primary human astrocytes. Inhibition of NF-kappaB activation by NaB suggests that NaB exerts its anti-inflammatory effect through the inhibition of NF-kappaB. Although NaB reduced the level of cholesterol in vivo in mice, reversal of the inhibitory effect of NaB on iNOS expression, and NF-kappaB activation by hydroxymethylglutaryl-CoA, mevalonate, and farnesyl pyrophosphate, but not cholesterol and ubiquinone, suggests that depletion of intermediates, but not end products, of the mevalonate pathway is involved in the anti-inflammatory effect of NaB. Furthermore, we demonstrate that an inhibitor of p21(ras) farnesyl protein transferase suppressed the expression of iNOS, that activation of p21(ras) alone was sufficient to induce the expression of iNOS, and that NaB suppressed the activation of p21(ras) in microglia. These results highlight a novel anti-inflammatory role of NaB via modulation of the mevalonate pathway and p21(ras).
Monitoring In Vitro and In Vivo Aroma Release of Espresso Coffees with Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry (2022)

This work presents in vitro and in vivo aroma release analysis of three espresso coffees carried out by PTR-ToF-MS headspace and nosespace analysis, respectively. The products were C. arabica coffees prepared using an espresso coffee machine: a low-caffeine C. arabica var. laurina light roast, a low-caffeine C. arabica var. laurina dark roast, and a single-origin coffee from Ethiopia which were roasted to a medium roast degree. Headspace analysis allowed for discrimination between coffees with a prediction accuracy of 92% or higher. Relevant discriminating compounds were related to the roasting degree and varietal compounds. Coffee nosespace consisted of 35 mass peaks overall. Despite this relatively low number of detected peaks, coffee discrimination was still possible with ≥93% accuracy. The compounds most relevant to the discrimination were those related to the roasting degree. Major differences—both qualitative and quantitative—were found between headspace and nosespace profiles.
Optomechanical Fluid-filled Model of the Human Eye (2011)

The following describes the design and performance of an optomechanical fluid-filled eye model and its use for testing flaws in an actual eye using optical components that can be modified to match an individual’s eye.
Supercontinuum generation covering the entire 0.4–5 µm transmission window in a tapered ultra-high numerical aperture all-solid fluorotellurite fiber (2018)

Enormous efforts have been made to realize supercontinuum (SC) generation covering the entire transmission window of fiber materials for their wide applications in many fields. Here we demonstrate ultra-broadband SC generation from 400 to 5140 nm in a tapered ultra-high numerical aperture (NA) all-solid fluorotellurite fiber pumped by a 1560 nm mode-locked fiber laser. The fluorotellurite fibers are fabricated using a rod-in-tube method. The core and cladding materials are TeO2–BaF2–Y2O3- and TeO2-modified fluoroaluminate glasses, respectively, which have large refractive index contrast and similar thermal expansion coefficients and softening temperatures. The NA at 3200 nm of the fluorotellurite fiber is about 1.11. Furthermore, tapered fluorotellurite fibers are prepared using an elongation machine. SC generation covering the entire 0.4–5 µm transmission window is achieved in a tapered fluorotellurite fiber for a pumping peak power of ~10.5 kW through synergetic control of dispersion, nonlinearity, confinement loss and other unexpected effects (e.g. the attachment of dust or water to the surface of the fiber core) of the fiber. Our results show that tapered ultra-high NA all-solid soft glass fibers have a potential for generating SC light covering their entire transmission window.
A SIMULATION LABORATORY FOR EVALUATION OF DYNAMIC TRAFFIC MANAGEMENT SYSTEM (1997)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1997.
Abstract 15608: Deficiency of Tlr4 Homologue Rp105 Aggravates Outward Remodelling in a Murine Model of Arteriovenous Fistula Failure (2016)

Introduction: Arteriovenous access dysfunction is still the Achilles’ heel of hemodialysis in patients with end-stage renal disease (ESRD) with a 1-year primary patency of only 60%.The pathophysiology of arteriovenous fistula (AVF) maturation failure is unknown but impaired outward remodeling and intimal hyperplasia are both considered to contribute. Radio protective (RP)105 is an important regulator of inflammatory TLR4 signalling, expressed on numerous cell types. In the present study, we defined cell specific effects of RP105-/- on vascular smooth muscle cells (VSMCs) and macrophages (mφ) in vitro and in vivo effects of RP105-/- on AVF maturation in a murine model of AVF failure. Methods: All in vitro experiments were performed on primary cells isolated from RP105-/- and wild type (WT) mice. AVFs were created in an end-to-side manner between v.jugularis and carotid a. in RP105-/- (n=13) and WT (n=11) mice. AVFs were harvested at day 14 and processed for morphometric analysis and immunohistochemistry. M...
Exciton interactions in the symmetrical dimeric aggregate of chlorophyll a monohydrate (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleExciton interactions in the symmetrical dimeric aggregate of chlorophyll a monohydrateVaughn J. Koester and Francis K. FongCite this: J. Phys. Chem. 1976, 80, 20, 2310–2312Publication Date (Print):September 1, 1976Publication History Published online1 May 2002Published inissue 1 September 1976https://pubs.acs.org/doi/10.1021/j100561a034https://doi.org/10.1021/j100561a034research-articleACS PublicationsRequest reuse permissionsArticle Views76Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
New results in stereo-based automatic vehicle guidance (2002)

Presents new results on vision based longitudinal and lateral vehicle control. The novel feature of this approach is the use of binocular vision. The authors integrate two modules consisting of an obstacle tracking algorithm based on binocular stereo, and a lane marker detection algorithm, and show that the integration results in a improved performance for each of the modules.
Effect of surface tension gradient driven convection in a laser melt pool: Three-dimensional perturbation model (1988)

A three-dimensional model of the thermocapillary flow within the molten region during laser surface heating is developed. This physically corresponds to the process of a stationary laser beam irradiating on the surface of a moving workpiece. The recirculating flow due to the surface tension gradient is much faster than the scanning motion. This allows a perturbation solution. The basic solution corresponds to the stationary axisymmetric case, and the perturbation is based on a small scanning velocity. The advantage of seeking a perturbation solution is that the three-dimensional flow is modeled by two sets of two-dimensional equations which are presumably much more tractable than the original three-dimensional equations. Numerical solutions are obtained. The solid-liquid interface is determined by an iterative scheme. In the presence of the recirculating flow, the heat transfer becomes convection dominated. The absorbed laser energy is convected sideways so that a wider and shallower molten region is obtained. The molten pool shape is obtained and presented. The effect of various operation parameters (such as laser power, beam radius) on the pool shape are obtained and discussed. The cooling rate of resolidifying materials is also determined. Trajectory of a fluid particle is presented. This provides the most realistic scenario of mixing in a laser melted pool obtained to date. This also gives a semiquantitative understanding of the mechanism of solute redistribution. The effect of alloying elements, which may change the temperature dependence to an increasing function, is also considered. A reverse recirculating vortex is obtained and its effect on pool shape is presented and discussed.
„Partnership for the Heart” - Entwicklung und Erprobung eines neuen telemedizinischen Monitoring-Systems (2007)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Evaluation of Prognostic Factors in Anti-MDA5 Antibody-Positive Patients in Chongqing, China: A Retrospective Study (2021)

Advanced age, low lymphocyte count and albumin, and increased levels of inflammatory markers may portend poor prognosis in anti-MDA5-positive patients. Extra-large doses of glucocorticoid may have no additional benefit in these patients.
<title>Description and evaluation of a non-DCT-based codec</title> (1995)

At this time, almost all (de-facto) video coding standards are DCT based. It would be wrong though to think that DCT is the only practical way to reach a reasonable compression ratio for a reasonable codec complexity. In this paper, a description of a complete hybrid codec based on OLA (Optimal Level Allocation) and HVS (Human Visual System) based classification is given. Then a performance comparison is made between this codec and an MPEG-2 like codec.
Prenatal diagnosis of the derivative chromosome 22 associated with cat eye syndrome by fluorescence in situ hybridization (1994)

Cytogenetic studies of cultured amniocytes demonstrated a karyotype of 46,XX/47,XX, +mar. A bisatellited, dicentric, distamycin-DAPI negative, NOR-positive marker was present in 76 per cent of the metaphases examined. Similar markers have been associated with cat eye syndrome (CES). We report on the utilization of fluorescence in situ hybridization (FISH) with a 14/22 alpha-satellite probe and a chromosome 22-specific cosmid for locus D22S9 to determine the origin of the prenatally detected supernumerary marker chromosome. FISH studies demonstrated that the marker is a derivative of chromosome 22 and enabled us to provide the family with additional prognostic information.
Enantioanalysis of Butaclamol Using Enantioselective Potentiometric Electrodes (2009)

Abstract Three enantioselective, potentiometric electrodes were proposed for the enantioanalysis of butaclamol. The electrodes were based on immobilization of maltodextrins (MDs) of different dextrose equivalences [4.0–7.0, I; 13–17, II; 16.5–19.5, III] into carbon paste. The electrodes based on MD I and II were used for the enantioanalysis of S-butaclamol within linear concentration ranges of 10−10 to 10−7 and 10−10 to 10−8, respectively, with slopes of 51.20 and 57.59 mV/decade of concentration; whereas the electrode based on MD III was used for the enantioanalysis of R-butaclamol within a linear concentration range between 10−10 and 10−7 with a slope of 58.50 mV/decade of concentration. Recoveries greater than 90% were recorded for the enantioanalysis of butaclamol in synthetic and urine samples.
Visual discovery and analysis (2000)

We have developed a flexible software environment called ADVIZOR for visual information discovery. ADVIZOR complements existing assumptive-based analyses by providing a discovery-based approach. ADVIZOR consists of five parts: a rich set of flexible visual components, strategies for arranging the components for particular analyses, an in-memory data pool, data manipulation components, and container applications. Working together, ADVIZOR's architecture provides a powerful production platform for creating innovative visual query and analysis applications.
Synthesis and x-ray analysis of 1,2,4,5-trioxazinane (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and x-ray analysis of 1,2,4,5-trioxazinaneMitsuyuki Mori, Tomohito Sugiyama, Masatomo Nojima, Shigekazu Kusabayashi, and Kevin J. McCulloughCite this: J. Am. Chem. Soc. 1989, 111, 17, 6884–6885Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/ja00199a083https://doi.org/10.1021/ja00199a083research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Structure of nonlocal gradient-drift instabilities in Hall E × B discharges (2016)

Gradient-drift (collisionless Simon-Hoh) instability is a robust instability often considered to be important for Hall plasma discharges supported by the electron current due to the E × B drift. Most of the previous studies of this mode were based on the local approximation. Here, we consider the nonlocal model which takes into account the electron inertia as well as the effects of the entire profiles of plasma parameters such as the electric, magnetic fields, and plasma density. Contrary to local models, nonlocal analysis predicts multiple unstable modes, which exist in the regions, where local instability criteria are not satisfied. This is especially pronounced for the long wavelength modes which provide larger contribution to the anomalous transport.
Les Diables dans la Passion d'Arnoul Greban (1981)

Les Diables dans la Passion d'Arnoul GrebanLe Moyen Age est souvent appelé l'Age de foi à cause de la grande influence de la religion chrétienne sur tous les aspects de la vie médiévale.Ainsi ne nous étonnons-nous pas que les dramaturges d'alors aient produit plusieur~ chefs-d'oeuvre religieux.Ces pièces se divisent en deux catégories: le miracle, dont le sujet est l'histoire d'un miracle de Notre-Dame ou d'un autre saint ou d'une autre sainte, et le mystère, dont le sujet est quelque histoire biblique ou des événements de la vie du Christ.Vers la fin du Moyen Age, au quinzième siècle, cette dernière catégorie a produit de grandes pièces sur la passion du Christ, pour la représentation desquelles il fallait plusieurs journées.Parmi ces mystères de la passion se trouve celui d'Arnoul Greban, Le Mistere de la passion Nostre Saulveur Jhesu Crist-:T Or le public médiéval, quoique dévot, éprouvait sans doute les mêmes difficultés que nous à se tenir tranquille et attentif pendant une pièce au sujet sérieux.Pour divertir l'assistance et la faire reposer au cours des longues représentations, on lardait les pièces religieuses de scènes franchement comiques.Les personnages diaboliques se prêtaient facilement à ce but à cause du goût de l'époque pour le bizarre et le cruel, et surtout à cause de leur défaite inévitable.Lz sens de la supériorité provoque souvent le rire.Plusieurs sujets religieux exigent d'ailleurs la présence des diables: la création, la désobéissance d'Adam, et la descente du Christ en enfer, par exemple.Tous ces sujets, et bien d'autres encore, se retrouvent dans la Passion de Greban; il est donc naturel qu'il y ait aussi beaucoup d'activité diabolique.J'aimerais dégager quelques aspects de la présence des diables dans cette pièce.Il serait peutêtre possible d'évoquer les conditions de vie en enfer
Complex Formation between Magnesocene (MgCp2) and NH3:  Implications for p-Type Doping of Group III Nitrides and the Mg Memory Effect (2004)

Magnesocene (biscyclopentadienylmagnesium) is a common precursor used for the p-type doping of GaN and other group III nitride materials. Unfortunately, difficulties remain with predictably controlling the incorporation of Mg during metal organic chemical vapor deposition (MOCVD) film growth, which often exhibits poorly understood “memory effects.” Although the formation of a reaction product between magnesocene and ammonia has been previously speculated, one has never been experimentally isolated or identified. We have spectroscopically observed and identified, for the first time, the adducts formed between magnesocene and ammonia. Density functional theory (DFT) quantum chemistry calculations have also been performed on the system to determine the structures and energetics of the reaction products. It was found that ammonia can form condensable Lewis acid−base complexes with magnesocene in both 1:1 and 2:1 ratios (i.e., NH3−MgCp2 and (NH3)2−MgCp2) via nucleophilic attack of NH3 at the positively charged Mg center of MgCp2. Adduct formation is reversible, and the 1:1 and 2:1 products can be converted to one another by controlling the NH3 partial pressure. The formation and condensation of both adducts at room temperature is the probable parasitic source that leads to many of the observed Mg incorporation difficulties during the p-type doping of group III nitride materials.
Nucleotide diversity of genes related to chlorogenic acid biosynthesis of coffea (2013)

Chlorogenic acids (CGAs) are important chemical compounds of Coffea spp. related to beverage quality as they affect its astringency and can change its aroma and flavor. About 310,000 Coffea Expressed Sequence Tags (ESTs) are available and provide access to the nucleotide variability of the plant and to the development of molecular markers linked to beverage quality for the main enzymes involved in biosynthesis of the CGAs: PAL, C4H, 4CL, CQT and C3’H. In this study we identified SNP, INDELS and SSR polymorphisms within the nucleotide sequences available from the Brazilian Coffee Genome database and from the NCBI. The EST sequences for CGAs were trimmed and clustered by the program Codon Code Aligner, and polymorphisms and their validation detected (chromatogram quality). We identified six isoforms for PAL, one for C4H, six for 4CL, two for CQT and two for C3’H. The contigs formed exhibited a total of 248 polymorphisms (236 SNPs and 12 INDELs), with 201 in the coding region (127 non-synonymous and 74 synonymous). The frequency of polymorphisms was greater in the UTR regions (1pol/54pb) in relation to the coding region (1pol/81pb). The analysis of C. arabica sequences allowed identification of two different subgroups of sequences, related to their ancestral genomes (C. canephora and C. eugenioides). The presence of 67,4% of the polymorphisms between the ancestral groups and 32,6% within the groups were observed em C. arabica . The characterization of nucleotide diversity on those genes is essential for further studies on differential expression of their homeologs, as well as the use of CGAs as molecular markers related to genetic mapping.
Optimal Power Control with Channel Uncertainty in Ad Hoc Networks (2019)

We consider a practical ad hoc network where the channel gains from the transmitters to the receivers are only known through their mean and covariance rather than complete distribution functions. Our goal is to minimize the weighted sum of transmission powers with certain throughput guarantees. Under such limited channel state information (due to channel uncertainty), we exploit chance-constrained programming (CCP), which allows occasional violation of throughput threshold as long as the probability of such violation is below a small tolerable constant (risk level). We show that by setting different risk levels, we are able to achieve a trade-off between controlled throughput violation (risk) and minimum power consumption in the network. Through extensive simulations, we show that our proposed solution is significantly better than conventional worst-case optimization (with no risk tolerance) in terms of feasibility and objective value.
Grundlagen der Gewebeabtragung mit Hilfe kontinuierlich durchstimmbarer, gepulster Laserstrahlung (1994)

Article Grundlagen der Gewebeabtragung mit Hilfe kontinuierlich durchstimmbarer, gepulster Laserstrahlung was published on January 1, 1994 in the journal Biomedical Engineering / Biomedizinische Technik (volume 39, issue s1).
Base-Victim Compression: An Opportunistic Cache Compression Architecture (2016)

The memory wall has motivated many enhancements to cache management policies aimed at reducing misses. Cache compression has been proposed to increase effective cache capacity, which potentially reduces capacity and conflict misses. However, complexity in cache compression implementations could increase cache power and access latency. On the other hand, advanced cache replacement mechanisms use heuristics to reduce misses, leading to significant performance gains. Both cache compression and replacement policies should collaborate to improve performance. In this paper, we demonstrate that cache compression and replacement policies can interact negatively. In many workloads, performance gains from replacement policies are lost due to the need to alter the replacement policy to accommodate compression. This leads to sub-optimal replacement policies that could lose performance compared to an uncompressed cache. We introduce a novel, opportunistic cache compression mechanism, Base-Victim, based on an efficient cache design. Our compression architecture improves performance on top of advanced cache replacement policies, and guarantees a hit rate at least as high as that of an uncompressed cache. For cache-sensitive applications, Base-Victim achieves an average 7.3% performance gain for single-threaded workloads, and 8.7% gain for four-thread multi-program workload mixes.