gebhart/patrepeval huggingface dataset:
SEMANTIC FEATURE BASED REGISTRATION OF TERRESTRIAL POINT CLOUDS (2009)

As an active remote sensing technique, Terrestrial Laser Scanning (TLS) is popular for constructing detailed 3D models of complex objects. To create a complete 3D scene, TLS point clouds scanned from multiple positions need to be registered to the same coordinate system. Conventional registration methods demand significant amount of manual work. Recent studies use geometric features (points, lines and planes) matching to automate the registration procedure. However, a fully automatic and simple registration method is still a popular research interest. In this paper, a new registration approach is proposed which uses semantic information to automate the geometric feature matching. Knowledge is used to identify semantic meaning of geometric features and classify them. The semantic type and spatial pattern of features is organized and analysed in a hierarchical manner. This provides a basis for structured feature matching reducing the search space and hence instigating automation in registration. Geometrical properties of obtained matches are used for coarse and fine registration through least squares adjustment. Our proposed approach was tested for registering building façade scans which yielded successful registration with high accuracy level.
In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249 (2007)

Hepatocellular carcinoma (HCC) is highly lethal due to limited curative options. In high-incidence regions, such as parts of Africa and Southeastern Asia, >50% of cases carry an AGG to AGT mutation at codon 249 of the TP53 gene, considered as a 'signature' of mutagenesis by aflatoxins. The protein product, p53ser249, may represent a therapeutic target for HCC. The small molecule p53 reactivation and induction of massive apoptosis (PRIMA)-1 has been shown to induce apoptosis in tumour cells by reactivating the transactivation capacity of some p53 mutants. In this study, we have investigated the cytotoxic effects of PRIMA-1 on HCC cells expressing p53ser249. In p53-null Hep3B cells, over-expression of p53ser249 or p53gln248 by stable transfection increased the cytotoxicity of PRIMA-1 at 50 muM. Furthermore, PRIMA-1 treatment delayed the growth of p53ser249-expressing Hep3B cells xenografted in severe combined immunodeficiency mice. However, PRIMA-1 did not restore wild-type DNA binding and transactivation activities to p53ser249 or to p53gln248 in Hep3B cells. Moreover, in PLC/PRF/5, a HCC cell line constitutively expressing p53ser249, small interfering RNA (siRNA) silencing of the mutant increased the cytotoxic effect of PRIMA-1. These apparently contradictory effects can be reconciled by proposing that p53ser249 exerts a gain-of-function effect, which favours the survival of HCC cells. Thus, both inhibition of this effect by PRIMA-1 and removal of the mutant by siRNA can lead to the decrease of survival capacity of HCC cells.
Hydrophone Acoustic Receiver Modeling: Turbulent Flow Modeling an d Acoustic Analysis (2014)

Ab stract: The field of underwater acoustics research is constantly growing with the ongoing improvement of acoustic measuring techniques. An acoustic hydrophone receiver is a passive listening device which is widely used in biological research and sonar technology. The hydrophone however suffers from turbulence generated noise created by its presence in ever faster flow. This work aims to analyze the pressure variations on a hydrophone receiver in flows with Reynolds numbers < 30,000 and quantify the acoustic power generated in the turbulent wake of the hydrophone using COMSOL Reynolds Averaged Navier-Stokes (RANS) fluid modelling physics.
High-precision gravity measurements using atom interferometry (2001)

We have built an atom interferometer that can measure g, the local acceleration due to gravity, with a resolution of Δg/g = 2 × 10−8 after a single 1.3 s measurement cycle, 3 × 10−9 after 1 min and 1 × 10−10 after two days of integration time. The difference between our value for g and one obtained by a falling corner-cube optical interferometer is (7 ± 7) × 10−9 g. The atom interferometer uses velocity-selective stimulated Raman transitions and laser-cooled caesium atoms in an atomic fountain. We extend previous methods of analysing the interferometer to include the effects of a gravitational gradient. We also present detailed experimental and theoretical studies of potential systematic errors and noise sources.
[The effect of benzenecarboxylic acids--in particular mellitic acid--in in vitro biological system]. (1989)

Influence of Benzenecarboxylic Acids, Particularly Mellitic Acid, on Biological in vitro Systems. In a first part of the present paper influences of mellitic acid and some other benzenecarboxylic acids on reduplication of Ehrlich ascites tumor cells cultured in vitro are reported. Mellitic acid in the concentration range between 1 and 5 mmol/l caused an increase, in concentrations of 10 mmol/l and above an inhibition of cell multiplication. Benzoic acid, phthalic acid, hemimellitic acid and pyromellitic acid showed in concentrations above 6 to 10 mmol/l inhibitory effects on cell multiplication. The second part reports studies on potential influences of mellitic acid on growth and mesenchymal metabolism of explanted murine fetal tibiae cultured in vitro for six days. Mellitic acid effected in concentrations between 0.5 and 15 mmol/l as compared with control cultures a concentration dependent inhibition of calcification and in concentrations above 2 mmol/l significant increases of the glycosaminoglycan content and growth of the explants, whereas DNA-, total protein- and hydroxyprolin content were not significantly influenced by concentrations up to 10 mmol/l.
Joint synchronization, routing and energy saving in CSMA/CA multi-hop hybrid networks (2005)

Multi-hop hybrid networks can help providing both high bandwidth and broad coverage for wireless data networks. We focus on CSMA/CA-based networks and take IEEE 802.11 as a concrete example. We show that the three fundamental operations of synchronization, routing and energy saving can be implemented in an integrated way. Our integrated solution is based on the periodic computation of a broadcast tree among the nodes reporting to the same access point, starting from the access point itself. We use the nodes that are tree vertices as relays for both data and control packets. We propose a distributed neighbor discovery protocol and a simple centralized algorithm for computing the broadcast tree. Our analysis and simulation results show that the proposed solution has low protocol overhead in terms of message passing and execution time, and performs well even if nodes are mobile.
Comparative effectiveness of topical treatments for hydrofluoric acid burns. (1985)

Hydrofluoric acid (HF) burns are characterized by progressive tissue necrosis and severe pain. Numerous topical treatments have been proposed, yet few have been studied experimentally. The present study was designed to examine the comparative efficacy of recommended treatments. Hair on the hind legs of rats was removed and 48 hours later 70% HF was applied. Calcium gluconate, Zephiran (benzalkonium chloride), A + D Ointment, aloe gel, and magnesium ointment were applied topically and burn development was monitored. Calcium gluconate significantly reduced burn size as early as one hour after application. Significant protection continued for seven days after the single application. The other treatments were not effective in decreasing or delaying HF burn development. The results indicated that calcium gluconate ointment was the most effective topical treatment for HF burns.
Sorption of hydrocarbons and water in silanated and unsilanated partial H-forms of zeolite Y (1979)

A study has been made of sorption at 30°C of n-hexane, 2-methylpentane, 2,2-dimethylbutane, cyclohexane, benzene and water in zeolite Y with 0, 31, 54 and 73% of the Na replaced by H, both before and after silanating these sorbents to different extents. Hydrocarbons were sorbed at 63 ± 2 Torr and water at 10 Torr. The three unsilanated partially H-exchanged forms of Y, in formation from Na–Y, each lost nearly the same fraction of sorption capacity for hydrocarbons and water as compared with Na–Y. It is suggested that regions of impermeable amorphous material had formed in similar amounts in each partial H-form, nucleated and developed on or in a matrix of parent crystal, as a result of bond breaking and re-making with different partners, associated with proton migration. Compared with the corresponding unsilanated form the silanated 31 and 54% H-exchanged Y gave enhanced uptakes. This was attributed in part to increased sorption energy because of interaction of sorbate not only with lattice atoms but also with the extra atoms introduced by silanation and subsequent reactions. While the silanated 31 and 54% H-exchanged Y freely sorbed all the hydrocarbons and water the silanated 73% H-forms were heavily blocked. Possible causes of this strong difference were discussed.
Evolution of leakage paths in HfO2∕SiO2 stacked gate dielectrics: A stable direct observation by ultrahigh vacuum conducting atomic force microscopy (2005)

A conducting atomic force microscopy (C-AFM) in ultrahigh vacuum (UHV) is used to directly observe the evolution of leakage path in HfO2∕SiO2 stacked gate dielectrics. Thanks to the UHV environment, reproducible results for both positive and negative tip biases are obtained without material formation on the surface, which has been a problem for atmospheric C-AFM. It is found that the density of leakage spots increases exponentially as a function of tip bias and that it is a large factor for leakage current increase.
Detection of Telomerase Activity in High Concentration of Cell Lysates Using Primer-Modified Gold Nanoparticles (2010)

Although the telomeric repeat amplification protocol (TRAP) has served as a powerful assay for detecting telomerase activity, its use has been significantly limited when performed directly in complex, interferant-laced samples. In this work, we report a modification of the TRAP assay that allows the detection of high-fidelity amplification of telomerase products directly from concentrated cell lysates. Briefly, we covalently attached 12 nm gold nanoparticles (AuNPs) to the telomere strand (TS) primer, which is used as a substrate for telomerase elongation. These TS-modified AuNPs significantly reduce polymerase chain reaction (PCR) artifacts (such as primer dimers) and improve the yield of amplified telomerase products relative to the traditional TRAP assay when amplification is performed in concentrated cell lysates. Specifically, because the TS-modified AuNPs eliminate most of the primer-dimer artifacts normally visible at the same position as the shortest amplified telomerase PCR product apparent on agarose gels, the AuNP-modified TRAP assay exhibits excellent sensitivity. Consequently, we observed a 10-fold increase in sensitivity for cancer cells diluted 1000-fold with somatic cells. It thus appears that the use of AuNP-modified primers significantly improves the sensitivity and specificity of the traditional TRAP assay and may be an effective method by which PCR can be performed directly in concentrated cell lysates.
Fredholm Multiple Kernel Learning for Semi-Supervised Domain Adaptation (2017)

As a fundamental constituent of machine learning, domain adaptation generalizes a learning model from a source domain to a different (but related) target domain. In this paper, we focus on semi-supervised domain adaptation and explicitly extend the applied range of unlabeled target samples into the combination of distribution alignment and adaptive classifier learning. Specifically, our extension formulates the following aspects in a single optimization: 1) learning a cross-domain predictive model by developing the Fredholm integral based kernel prediction framework; 2) reducing the distribution difference between two domains; 3) exploring multiple kernels to induce an optimal learning space. Correspondingly, such an extension is distinguished with allowing for noise resiliency, facilitating knowledge transfer and analyzing diverse data characteristics. It is emphasized that we prove the differentiability of our formulation and present an effective optimization procedure based on the reduced gradient, guaranteeing rapid convergence. Comprehensive empirical studies verify the effectiveness of the proposed method.
Insulin Lispro (1997)

The difference in amino acid composition between beef and porcine insulins and human insulin was long thought to be responsible for the immunogenicity of these animal insulins in humans. As a result, much of the effort expended to meet the world's increasing demand for insulin was devoted to the development of synthetic human insulin. However, the introduction of highly purified synthetic human insulin in the early 1980s did not entirely solve the problem of immunogenicity, and the new technology was used instead to change the amino acid structure of human insulin to make it more suitable for subcutaneous administration. This . . .
Intragenic Suppressors of an OmpF Assembly Mutant and Assessment of the Roles of Various OmpF Residues in Assembly through Informational Suppressors (2001)

We employed two separate genetic approaches to examine the roles of various OmpF residues in assembly. In one approach, intragenic suppressors of a temperature-sensitive OmpF assembly mutant carrying a W214E substitution were sought at 42 degrees C, or at 37 degrees C in a genetic background lacking the periplasmic folding factor SurA. In the majority of cases (58 out of 61 revertants), the suppressors mapped either at the original site (position 214) or two residues downstream from it. In the remaining three revertants that were obtained in a surA background, an alteration of N230Y was located 16 residues away from the original site. The N230Y suppressor also corrected OmpF315 assembly at 42 degrees C in a surA(+) background, indicating that the two different physiological environments imposed similar assembly constraints. The specificity of N230Y was tested against five different residues at position 214 of mature OmpF. Clear specificity was displayed, with maximum suppression observed for the original substitution at position 214 (E214) against which the N230Y suppressor was isolated, and no negative effect on OmpF assembly was noted when the wild-type W214 residue was present. The mechanism of suppression may involve compensation for a specific conformational defect. The second approach involved the application of informational suppressors (Su-tRNA) in combination with ompF amber mutations to generate variant OmpF proteins. In this approach we targeted the Y40, Q66, W214, and Y231 residues of mature OmpF and replaced them with S, Q, L, and Y through the action of Su-tRNAs. Thus, a total of 16 variant OmpF proteins were generated, of which three were identical to the parental protein, and two variants carrying W214Q and Y231Q substitutions were similar to assembly-defective proteins isolated previously (R. Misra, J. Bacteriol. 175:5049-5056, 1993). The results obtained from these analyses provided useful information regarding the compatibility of various alterations in OmpF assembly.
Polymers of 1-Vinyl-2-Pyrrolidinone as Potential Vitreous Substitutes: Physical Selection (1996)

More than 300 polymers of 1-vinyl-2-pyrrolidinone (VP) were synthesized, subjected to hydration, and characterized with the aim to select the most suitable materials as potential artificial substitutes for the vitreous body of the eye. The materials include cross-linked homopolymers, uncross-linked copolymers of VP with 2-hydroxyethyl methacrylate (HEMA), and cross-linked copolymers VP/HEMA. Five different cross-linking agents, both hydrophobic and hydrophilic, were used in this study. The resulting hydrogels, with equilibrium water contents ranging between 66.5 and 99.1%, were first subjected to a selection based on their physical behavior during manipulation, after which only the transparent, viscoelastic gels were further considered. Subsequent injectability and visual acuity tests, as well as the evaluation of light transmission characteristics, reduced further the number of potential candidates for vitreous substitution to only thirteen hydrogels. An eliminatory strategy based on physical properties of the potential vitreous substitutes is essential in order to avoid unnecessary sacrifice of experimental animals for in vivo assessment.
Graded index Sol-Gel antireflection coatings (2013)

We explore graded index antireflection coatings that can reduce reflection of light at the ambient/cell or ambient/module boundary at all wavelengths and incidence angles. Simulations show that graded index coatings individually enhance absorption in solar cells across nearly the entire wavelength range. Silica sol-gel coatings with varying refractive indices deposited onto glass and silicon substrates are used to form graded index coatings, and the sol-gel layer processes have been adjusted so that the refractive indices are tunable from n=1.1 to n=1.5. Reflectance measurements also show that reflectivity decreases across the entire spectrum with added solgel multilayers.
Towards a Smart Encapsulation System for Small-Sized Electronic Devices: A New Approach (2014)

Miniaturized analytical chip devices like biosensors nowadays provide assistance in highly diverse fields of application such as point-of-care diagnostics and industrial bioprocess engineering. However, upon contact with fluids, the sensor requires a protective shell for its electrical components that simultaneously offers controlled access for the target analytes to the measuring units. We therefore developed a capsule that comprises a permeable and a sealed compartment consisting of variable polymers such as biocompatible and biodegradable polylactic acid (PLA) for medical applications or more economical polyvinyl chloride (PVC) and polystyrene (PS) polymers for bioengineering applications. Production of the sealed capsule compartments was performed by heat pressing of polymer pellets placed in individually designable molds. Controlled permeability of the opposite compartments was achieved by inclusion of NaCl inside the polymer matrix during heat pressing, followed by its subsequent release in aqueous solution. Correlating diffusion rates through the so made permeable capsule compartments were quantified for preselected model analytes: glucose, peroxidase, and polystyrene beads of three different diameters (1.4 μ m, 4.2 μ m, and 20.0 μ m). In summary, the presented capsule system turned out to provide sufficient shelter for small-sized electronic devices and gives insight into its potential permeability for defined substances of analytical interest.
Purdue University Buildings Demolition, Construction Images, May 2016, MATH Building Camera (2016)

&lt;p&gt;[[Video(http://www.youtube.com/watch?v=H0LRUs2-ON0)]]&lt;/p&gt; &lt;p&gt;Purdue&amp;#39;s campus landscape continues to change with the construction of new buildings and the remodel of old buildings. In 2012 the Engineering Administration Building (ENAD) and the iconic Heat and Power Plant-North (HPN) were targeted for demolition to make way for the construction of the Wilmeth Active Learning Center (WALC); a building with offices, collaborative spaces and classrooms with an emphasis on new instructional models. The Purdue University Lyles School of Civil Engineering capitalized on a key opportunity for education and research. Five cameras were installed to capture images from the demolition of the Engineering Administration Building and the Power Plant, to the construction of the Wilmeth Active Learning Center. The images from 3 fixed cameras situated on the Mathematical Sciences Building (MATH) and the Potter (A. A.) Engineering Center (POTR) can be accessed and used for educational and research purposes.&lt;/p&gt; &lt;p&gt;Representative time lapse videos were created from these three cameras for each month of the project. The time lapse videos created from these images - 08:00 to 18:00, 7 days a week in each month - are accessible here: &lt;a href="http://dx.doi.org/10.4231/R70P0WXD"&gt;http://dx.doi.org/10.4231/R70P0WXD&lt;/a&gt;.&lt;/p&gt;
Photocatalytic Mechanism Regulation of Bismuth Oxyhalogen via Changing Atomic Assembly Method (2017)

Exciton and carrier photocatalytic processes have been proved in bismuth oxyhalogen photocatalysts. But, there are no reports about how to regulate the different mechanisms to improve photocatalytic activity for different reaction. Here, we found that the photocatalytic mechanisms could be regulated by changing the assembly method of bismuth, oxygen, and halogen atoms. Reactive oxygen species (ROS) experimentals results concluded that solid solution BiOBr<sub>0.5</sub>I<sub>0.5</sub> showed enhanced exciton photocatalytic process, and coupling 0.5BiOBr/0.5BiOI displayed improved carrier photocatalytic proces. This work promoted the understanding about solid solution and coupling for bismuth oxyhalogen.
Establishment of a human cell line (mono mac 6) with characteristics of mature monocytes (1988)

A monocytic cell line, termed Mono Mac, was established from peripheral blood of a patient with monoblastic leukemia. Two clones, designated Mono Mac I and Mono Mac 6, were isolated and both were assigned to the monocyte lineage on the basis of morphological, cytochemical and immunological criteria. Most importantly, the clones express NaF-sensitive non-specific-esterase, produce reactive oxygen and stain with MAb My4. Mono Mac 6, in addition, constitutively exhibits phagocytosis of antibody-coated erythrocytes in 80% of the cells and reacts with a panel of MAbs that are specific for mature monocytes, i.e., M42, LeuM3, 63D3, Mo2 and UCHMI. By contrast, the monoblastic cell lines U937 and THP-I are negative for all these markers. Only expression of My4 could be detected after differentiation induced by interferon-gamma (IFN-gamma). Similar treatment of Mono Mac I, however, resulted in staining with all the monocyte-specific MAbs mentioned above, while IFN-gamma treatment of Mono Mac 6 enhanced antigen expression. In addition, the cells showed an increased frequency of multinucleated cells with a rise from 4.8% to 21.9%. Mono Mac 6 appears to be the only one of the cell lines studied to constitutively express phenotypic and functional features of mature monocytes.