gebhart/patrepeval huggingface dataset:
Proton Irradiation of Choroidal Melanomas (1978)

Choroidal malignant melanomas in nine patients were treated with proton beam irradiation at the Harvard Cyclotron Laboratory, Cambridge, Mass. Each patient received five proton beam treatments in eight to ten days, totalling 4,730 to 8,570 rads at the tumor. No complications occurred during the treatment or follow-up period, which, at the time of this writing, ranges from one to 24 months, with an average of 12 months. No further growth of the tumor has been observed in any patient. Different signs of tumor regression have been noted. Resolution of the serous retinal detachments that accompanied some tumors is the earliest finding. Pigment changes over the surface of the tumor and adjacent pigment epithelium is a usual initial tumor response. Fluorescein angiography initially showed decreased leakage of dye; later, destruction of the tumor's vasculature and elimination of fluorescein leakage became evident. Only large choroidal vessels remained patient. Ultrasonography revealed decreased height of the tumors postirradiation, and the radioactive phosphorus (32P) uptake test, repeated in one patient, turned negative on postirradiation measurements.
Anti-hyperalgesic effect of Mangifera indica L. extract on the sciatic chronic constriction injury model in rats (2011)

Context: The aqueous extract of Mangifera indica L. stem bark (MSBE) shows antioxidant, anti-inflammatory and analgesic properties. Aims: To test the MSBE in chronic constriction injury (CCI) of the sciatic nerve in rats, a classical model of neuropathic pain. Methods: Given the possibility that some clinical effect of MSBE can appear only after its chronic administration, we designed a long term medication protocol with 500 mg/kg, p.o. or distilled water daily during 8 days from 9 days post-CCI. Pregabalin (10 mg/kg, p.o.) was used as reference drug. Sham CCI animals received vehicle. Behavioral tests were carried out before CCI, at 9 and 16 days after injury. A section of sciatic nerve, 5 mm distal to the ligature site was dissected for histopathological studies. A single oral similar dose or vehicle was administered to mononeuropathic rats, 14 days after surgery. Mechano-hyperalgesia and thermal hyperalgesia of the ipsilateral paw were determined using a modification of pin prick method and the unilateral hot plate, respectively before CCI, 0, 30, 60, 120 and 180 min post-administration. Results: Repeated oral MSBE doses reduced nociceptive score, increased paw withdrawal latency and attenuated CCI-induced Wallerian degeneration-related changes involved in the hyperalgesic state of CCI rats. Likewise, MSBE shows significant mechanical and thermal anti-hyperalgesic effect from 1h after its single administration. Conclusions: The study of MSBE should be focused in neuropathic pain models since this natural product could have a clinical relevance in the treatment of neuropathic pain syndromes.
PREMIERS RESULTATS D'UNE ETUDE D'ANALYSE FOLIAIRE SUR L'AVOCATIER "LULA" A LA MARTINIQUE (1977)

Etude qui a permis de mettre en evidence l'influence des techniques culturales (fumure, taille) climat et relation entre les elements sur les niveaux foliaires. Elle a permis de preciser, pour la Martinique, la technique du prelevement et d'obtenir des premieres indications en vue d'interpretation des resultats: choix des feuilles a prelever, fixation des dates de prelevement, etablissement provisoire de niveaux foliaires de reference pour la variete Lula
Effect of actin on the tryptic digestion of myosin subfragment 1 in the weakly attached state (1992)

The structure of myosin subfragment 1 (S1) in the weakly attached complex with actin was studied at three specific sites, at the 50-kDa/20-kDa and 27-kDa/50-kDa junctions, and at the N-terminal region, using tryptic digestion as a structure-exploring tool. The structure of S1 at the vicinity of the 50-kDa/20-kDa junction is pH dependent in the weakly attached state because the tryptic cleavage at this site was fully protected by actin at pH 6.2, but the protection was only partial at pH 8.0. Since the actin protection is complete in rigor at both pH values, the results indicate that the structure of S1 at the 50-kDa/20-kDa junction differs in the two states at pH 8.0, but not at pH 6.2. Actin restores the ADP-suppressed tryptic cleavage after Lys213 at the 27-kDa/50-kDa junction in the strongly attached state, but not in the weakly attached state, which indicates structural difference between the two states at this site. ATP and ADP open a new site for tryptic cleavage in the N-terminal region of the S1 heavy chain between Arg23 and Ile24. Actin was found to suppress this cleavage in both weakly and strongly attached states, which shows that, in the vicinity of this site, the structure of S1 is similar in both states. The results indicate that the binding of S1 to actin induces localized changes in the S1 structure, and the extent of these changes is different in the various actin-S1 complexes.
AWARENESS OF DIABETES RISK FACTOR & COMPLICATIONS AMONG DIABETIC POPULATION AT A TERTIARY CARE TEACHING HOSPITAL (2014)

Multiple studies from various parts of India have revealed a rising trend in the prevalence of type II diabetes in the urban areas. An increase of 12.1% in the prevalence of diabetes was noted in National Urban Survey of year 2000. In addition, socio-economic transition in rural areas has led to a rise from 2.4% to 6.4% in the incidence of diabetes. This cross-sectional community-based study was conducted in MVJ hospital, Bangalore. The study samples were collected from each ward. A total of 115 diabetic patients were interviewed through a predesigned questionnaire. Subjects age > 15 years, either have been diagnosed as diabetes or using any hypoglycaemic medication were selected for the study. The questions were designed to elicit details of age, gender, educational status, socioeconomically status, family history of diabetes, general knowledge, knowledge of risk factors and awareness of complications for each participant. The mean (±SD) diabetes risk factor awareness score of all participants was 3.137615±0.125536 out of a total score of 7. The mean (±SD) diabetes complication awareness score of all participants was 2.481818±0.091991 out of a total score of 6. As we considered that, three and more, correct Article Received on 24 May 2014, Revised on 15 June 2014, Accepted on 03 July 2014 *Correspondence for Author Shahnooshi Javad F Doctor of Pharmacy (Indian Pharmaceutical Association Member), Department of Pharmacy Practice, Krupandhi College of Pharmacy, Chikkabellandur Village, Varthur Hobli, Bangalore 560035, India WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 2.786 Volume 3, Issue 8, 549-560. Research Article ISSN 2278 – 4357
From speculative university research to Silicon Valley Company and back (2005)

This talk provides a summary of the author&apos;s experience in the successful transfer what of began as speculative university research into commercial application. The early part of the talk will briefly describe how was this was initially done as a result of joint research projects with a number of UK companies, including the benefits and limitations encountered. An overview will then be given of his experiences in the creation and the growth of two high technology companies based on research done within his laboratory. The first of these, Audio Processing Technology Ltd. was established to commercialise one of the first published hi-fi audio compression algorithms, with its technology later to be used as the basis of Digital Theatre Sound (DTS), first used in the movie "Jurassic Park". The second, Amphion Semiconductor, was established to commercially develop research on innovative silicon architectures for Signal and Video Processing. Amphion is now a major supplier of SoC cores for video compression and was acquired by Connexant Systems Inc. in June 2004. The latter part of the talk will provide a brief overview of the new #40M Institute of Electronics Communications and Information Technology [ECIT) which is located on the N. Ireland Science Park, adjacent to where the Titanic Cruise liner was built. This builds on the university&apos;s international expertise in electronics and computer science (www.ecit.qub.ac.uk). Its mission is to stimulate major opportunities for economic growth, by pioneering future directions and innovation in key areas of advanced technology through the integration of complementary research expertise in a world-leading facility. This cover the range from blue skies and applied research, through innovation and commercial development to strong links with industry and includes new company creation, both spin-off and spin-in, companies. (20 pages)
Field Postmortem Rabies Rapid Immunochromatographic Diagnostic Test for Resource-Limited Settings with Further Molecular Applications (2020)

Functional rabies surveillance systems are crucial to provide reliable data and increase the political commitment necessary for disease control. To date, animals suspected as rabies-positive must be submitted to a postmortem confirmation using classical or molecular laboratory methods. However, most endemic areas are in low- and middle-income countries where animal rabies diagnosis is restricted to central veterinary laboratories. Poor availability of surveillance infrastructure leads to serious disease underreporting from remote areas. Several diagnostic protocols requiring low technical expertise have been recently developed, providing opportunity to establish rabies diagnosis in decentralized laboratories. We present here a complete protocol for field postmortem diagnosis of animal rabies using a rapid immunochromatographic diagnostic test (RIDT), from brain biopsy sampling to the final interpretation. We complete the protocol by describing a further use of the device for molecular analysis and viral genotyping. RIDT easily detects rabies virus and other lyssaviruses in brain samples. The principle of such tests is simple: brain material is applied on a test strip where gold conjugated antibodies bind specifically to rabies antigens. The antigen-antibody complexes bind further to fixed antibodies on the test line, resulting in a clearly visible purple line. The virus is inactivated in the test strip, but viral RNA can be subsequently extracted. This allows the test strip, rather than the infectious brain sample, to be safely and easily sent to an equipped laboratory for confirmation and molecular typing. Based on a modification of the manufacturer's protocol, we found increased test sensitivity, reaching 98% compared to the gold standard reference method, the direct immunofluorescence antibody test. The advantages of the test are numerous: rapid, easy-to-use, low cost and no requirement for laboratory infrastructure, such as microscopy or cold-chain compliance. RIDTs represent a useful alternative for areas where reference diagnostic methods are not available.
Modification in non-combining idioms (2011)

This squib discusses metalinguistic modification, expressives, domain modification, hypallage, and conjunctive modification within verb phrase idioms. The examples presented here show that non-combining idioms, to use terminology based on that of Nunberg, Sag & Wasow 1994, allow for modifiers on their internal constituents, but only in certain circumstances. This observation is shown to be derived from the fact that the idiomatic reading of these non-combining idioms is associated with the entire verb phrase. http://dx.doi.org/10.3765/sp.4.7 BibTeX info
The muscarinic cholinergic binding kinetics of the human urinary bladder (1982)

Abstract Determination of (1) the absolute number of cholinergic receptors, (2) the cholinergic binding kinetics, and (3) the direct antimuscarinic activity of a series of uropharmacologic agents was accomplished by radioligand binding techniques in tissue derived from human urinary bladder. The competition between 3 H‐quinuclidinyl benzilate ( 3 H‐QNB) binding and selective antagonists provided the first quantitative assessment of cholinergic receptor characteristics in the human bladder fundus and represents a potential method for assessing the antimuscarinic binding potential of uropharmacologic agents.
Spreading characteristics of an insoluble surfactant film on a thin liquid layer: comparison between theory and experiment (2005)

We describe measurements of the surface slope and reconstruction of the interface shape during the spreading of an oleic acid film on the surface of a thin aqueous glycerol mixture. This experimental system closely mimics the behaviour of an insoluble surfactant film driven to spread on a thin viscous layer under the action of a tangential (Marangoni) surface stress. Refracted image Moiré topography is used to monitor the evolution of the surface slope over macroscopic distances, from which the time variant interface shape and advancing speed of the surfactant film are inferred. The interfacial profile exhibits a strong surface depression ahead of the surfactant source capped by an elevated rim at the surfactant leading edge. The surface slope and shape as well as the propagation characteristics of the advancing rim can be compared directly with theoretical predictions. The agreement is quite strong when the model allows for a small level of pre-existing surface contamination of the initial liquid layer. Comparison between theoretical and experimental profiles reveals the importance of the initial shear stress in determining the evolution in the film thickness and surfactant distribution. This initial stress appears to thin the underlying liquid support so drastically that the surfactant droplet behaves as a finite and not an infinite source, even though there is always an excess of surfactant present at the origin.
Surgical Exposure of the Sciatic Nerve in the Gluteal Region: Anatomic and Historical Comparison of Two Approaches (2005)

At the present time, the majority of peripheral nerve surgeons use an infragluteal approach to the proximal sciatic nerve. However, for select patients with well-defined and localized lesions, the transgluteal approach may provide sufficient nerve exposure with lowered operative complexity and postoperative morbidity.
The Trends of Atrial Fibrillation-Related Hospital Visit and Cost, Treatment Pattern and Mortality in Korea: 10-Year Nationwide Sample Cohort Data (2016)

During the last decade, AF-related hospitalization and outpatient clinic visits have increased with the increase of many other comorbidities, whereas the rate of anticoagulation did not improved. Although mortality in patients with AF showed a modest decrease from 2004 to 2013, proper anticoagulation therapy is warranted for the improvement of public health.
Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase Region in Norovirus Genogroup II (2018)

Noroviruses are the leading cause of viral gastroenteritis in humans across the world. RNA-dependent RNA polymerase (RdRp) plays a critical role in the replication of the viral genome. Although there have been some reports on a limited number of genotypes with respect to the norovirus evolution of the <i>RdRp</i> region, no comprehensive molecular evolution examination of the norovirus GII genotype has yet been undertaken. Therefore, we conducted an evolutionary analysis of the 25 genotypes of the norovirus GII <i>RdRp</i> region (full-length), collected globally using different bioinformatics technologies. The time-scaled phylogenetic tree, generated using the Bayesian Markov Chain Monte Carlo (MCMC) method, indicated that the common ancestor of GII diverged from GIV around 1443 CE [95% highest posterior density (HPD), 1336-1542]. The GII <i>RdRp</i> region emerged around 1731 CE (95% HPD, 1703-1757), forming three lineages. The evolutionary rate of the <i>RdRp</i> region of the norovirus GII strains was estimated at over 10<sup>-3</sup> substitutions/site/year. The evolutionary rates were significantly distinct in each genotype. The composition of the phylogenetic distances differed among the strains for each genotype. Furthermore, we mapped the negative selection sites on the RdRp protein and many of these were predicted in the GII.P4 RdRp proteins. The phylodynamics of GII.P4, GII.P12, GII.P16, and GII.Pe showed that their effective population sizes increased during the period from 2003 to 2014. Our results cumulatively suggest that the <i>RdRp</i> region of the norovirus GII rapidly and uniquely evolved with a high divergence similar to that of the norovirus <i>VP1</i> gene.
Microstructure characterization of hypereutectoid aluminium bronze composite coating (2015)

Hypereutectoid aluminium bronze coating was deposited onto an E.N. 10503 steel using plasma transferred arc welding (PTA). Microstructure characterisation of the coating and a section near the steel substrate joint was carried out using SEM, EBSD, EDS in conjunction with XRD and depth-sensing nano-indentation. The constituent phases in the coating were identified as: martensitic Cu3Al ?1' phase, solid solution of Al in Cu ? phase and the intermetallic Fe3Al ?1 phase. The region near the steel substrate was characterised by high hardness, large grains and presence of Cu precipitates. No cracks were observed in this region. The coating has high hardness of 4.9GPa and Young’s modulus of 121.7GPa. This is attributed to homogeneous distribution of sub microns size Fe3Al intermetallic phase. The implications of the coating to the engineering application of sheet metal forming are discussed
Formation, properties, and practical applications of clay—organic complexes (1972)

Abstract T HIS paper summarises the development of and advances in the chemistry of clay—organic reactions. A brief outline is given of the structural features of clays and those peculiarities of the mineral surface that influence their behaviour towards organic compounds. This is followed by a discussion of the formation and properties of the different types of clay—organic complex, including some examples of the practical application of the clay—organic interaction. The unit‐layer charge of the clay surface, the nature of the exchangeable cation, and that of the organic species, as well as the water content of the system, influence the interaction between clays and organic molecules. The part played by clays in catalysing the transformation and polymerisation of certain adsorbed organic compounds and in chemical evolution is briefly discused.
Looking back at being the editor of CCR (2013--2016) (2019)

Our community is celebrating 50 years and I was asked to provide my perspective on one of its longest standing communication vehicles, ACM SIGCOMM Computer Communication Review, as one of its editors.
The η Isoform of Protein Kinase C Is Localized on Rough Endoplasmic Reticulum (1994)

The eta isoform of protein kinase C, isolated from a cDNA library of mouse skin, has unique tissue and cellular distributions. It is predominantly expressed in epithelia of the skin, digestive tract, and respiratory tract in close association with epithelial differentiation. We report here that this isoform is localized on the rough endoplasmic reticulum in transiently expressing COS1 cells and constitutively expressing keratinocytes. By the use of polyclonal antibodies raised against peptides of the diverse D1 and D2/D3 regions, we found that immunofluorescent signals were strongest in the cytoplasm around the nucleus and became weaker toward the peripheral cytoplasm. Under immunoelectron microscopic examination, electron-dense signals were located on the rough endoplasmic reticulum and on the outer nuclear membrane which is continuous with the endoplasmic reticulum membrane. However, no signals were detected in the nucleus, inner nuclear membrane, smooth endoplasmic reticulum, Golgi apparatus, mitochondria, or plasma membrane. Treatment of the cells in situ with detergents suggested association of the isoform of protein kinase C with intracellular structures. By immunoblotting, a distinct single band with an M(r) of 80,000 was detected in whole-cell lysate and in rough microsomal and crude nuclear fractions, all of which contain outer nuclear membrane and/or rough endoplasmic reticulum. We further demonstrated the absence of a nuclear localization signal in the pseudosubstrate sequence. The present observation is not consistent with the report of Greif et al. (H. Greif, J. Ben-Chaim, T. Shimon, E. Bechor, H. Eldar, and E. Livneh, Mol. Cell. Biol. 12:1304-1311, 1992).
Two-Level Multifactor Designs for Detecting the Presence of Interactions (1983)

A design optimality criterion, tr (L)-optimality, is applied to the problem of designing two-level multifactor experiments to detect the presence of interactions among the controlled variables. We give rules for constructing tr (L)-optimal foldover designs and tr (L)-optimal fractional factorial designs. Some results are given on the power of these designs for testing the hypothesis that there are no two-factor interactions. Augmentation of the tr (L)-optimal designs produces designs that achieve a compromise between the criteria of D-optimality (for parameter estimation in a first-order model) and tr (L)-optimality (for detecting lack of fit). We give an example to demonstrate an application to the sensitivity analysis of a computer model.
An evaluation of large-scale methods for image instance and class\n discovery (2017)

This paper aims at discovering meaningful subsets of related images from\nlarge image collections without annotations. We search groups of images related\nat different levels of semantic, i.e., either instances or visual classes.\nWhile k-means is usually considered as the gold standard for this task, we\nevaluate and show the interest of diffusion methods that have been neglected by\nthe state of the art, such as the Markov Clustering algorithm.\n We report results on the ImageNet and the Paris500k instance dataset, both\nenlarged with images from YFCC100M. We evaluate our methods with a labelling\ncost that reflects how much effort a human would require to correct the\ngenerated clusters.\n Our analysis highlights several properties. First, when powered with an\nefficient GPU implementation, the cost of the discovery process is small\ncompared to computing the image descriptors, even for collections as large as\n100 million images. Second, we show that descriptions selected for instance\nsearch improve the discovery of object classes. Third, the Markov Clustering\ntechnique consistently outperforms other methods; to our knowledge it has never\nbeen considered in this large scale scenario.\n
High Energy Cathode with Al2O3 Coating Formed by Atomic Layer Deposition (2012)

Abstract not Available.
Hydroxyapatite-Coated Proximal Ingrowth Femoral Stems (1995)

A matched pair study of 2 groups of 42 uncemented total hip replacements were compared retrospectively after a minimum 3-year followup. Forty-two hips were implanted with a hydroxyapatite coating on the proximal femoral patched porous surfaces; 42 hips had patched porous-coated stems without hydroxyapatite. There were no clinical differences between the matched groups by any criteria of measurement. There was no statistically significant difference between the matched groups for femoral stem fixation at all followup intervals. At the 3-year followup, 90% of the femoral stems in the hydroxyapatite porous group, and 83% in the porous control group achieved stable bony fixation. Hydroxyapatite-coated femoral stems demonstrated accelerated bone remodeling characterized by proximal cancellous hypertrophy. The percentage of femoral stems exhibiting cancellous hypertrophy was significantly greater at all followup intervals. This study did not demonstrate any clinical advantage of hydroxyapatite being added to a porous-coated surface. The radiographic changes of bone remodeling seen with hydroxyapatite are not known to improve durability of the hip arthroplasty. This study again condemns the use of patched porous-coating and titanium-bearing surfaces.