gebhart/patrepeval huggingface dataset:
Object imaging with a piezoelectric robotic tactile sensor (1995)

A two-dimensional, electrically multiplexed robotic tactile sensor was realized by coupling a piezoelectric polyvinylidene fluoride (PVDF) polymer film to a monolithic silicon integrated circuit (IC). The IC incorporates 64 sensor electrodes arranged in a symmetrical 8/spl times/8 matrix. Each electrode occupies a 400/spl times/400 /spl mu/m square area, and they are separated from each other by 300 /spl mu/m. A 40-/spl mu/m-thick piezoelectric PVDF polymer film was attached to the electrode array with an electrically nonconductive methane adhesive. The response of the tactile sensor is linear for loads spanning 0.8-135 grams-of-force (gmf) (0.00-1.35 Newtons (N)). The response bandwidth is 25 Hz, the hysteresis level is tolerable, and, for operation in the sensor's linear range, taxel crosstalk is negligible. The historically persistent stability and response reproducibility limitation associated with piezoelectric-based tactile sensors has been solved by implementing a novel pre-charge voltage bias technique to initialize the pre- and post-load sensor responses. A rudimentary tactile object image measurement procedure for applied loads has been devised to recognize the silhouette of a sharp edge, square, trapezoid, isosceles triangle, circle, toroid, slotted screw, and cross-slotted screw.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
In VitroandIn VivoComparative Studies on Immunosuppressive Properties of Cyclosporines A, C, D and Metabolites M1, M17 and M21 (1993)

Cyclosporine A (CsA) and its major metabolites: M1, M17 and M21 and two analogues: cyclosporines C (CsC) and D (CsD), were studied for their capacity to interfere with different in vitro activation pathways. Their inhibition potentials against the reaction of Graft-versus-Host (GvH) were also studied. The results showed: CsA, CsC and metabolite M17 were the most active compounds upon the inhibition of lymphocyte proliferation induced by different mitogens (ConA, PHA, PWM) and also on the proliferation of mixed lymphocyte cultures (MLC). The same results were observed concerning the direct activation by protein kinase C using a combined action of phorbol ester + calcium ionophore. In vivo using local GvH reaction, CsA and CsC proved more active than M17 in the two different combinations: H-2d --> (H-2b x H-2d)F1 and H-2k --> (H-2b x H-2k)F1 CsD and two metabolites M1 and M21 showed no or weak immunosuppressive effects. Overall, the immunosuppressive potency of six compounds could be schematized as: CsA > or = CsC > M17 > M1 > or = CsD > M21.
CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro (2017)

CC-115, a selective dual inhibitor of the mammalian target of rapamycin (mTOR) kinase and DNA-dependent protein kinase (DNA-PK), is undergoing Phase 1 clinical studies. Here we report the characterization of DNA-PK inhibitory activity of CC-115 in cancer cell lines. CC-115 inhibits auto-phosphorylation of the catalytic subunit of DNA-PK (DNA-PKcs) at the S2056 site (pDNA-PK S2056), leading to blockade of DNA-PK-mediated non-homologous end joining (NHEJ). CC-115 also indirectly reduces the phosphorylation of ataxia-telangiectasia mutated kinase (ATM) at S1981 and its substrates as well as homologous recombination (HR). The mTOR kinase and DNA-PK inhibitory activity of CC-115 leads to not only potent anti-tumor activity against a large panel of hematopoietic and solid cancer cell lines but also strong induction of apoptosis in a subset of cancer lines. Mechanistically, CC-115 prevents NHEJ by inhibiting the dissociation of DNA-PKcs, X-ray repair cross-complementing protein 4 (XRCC4), and DNA ligase IV from DNA ends. CC-115 inhibits colony formation of ATM-deficient cells more potently than ATM-proficient cells, indicating that inhibition of DNA-PK is synthetically lethal with the loss of functional ATM. In conclusion, CC-115 inhibits both mTOR signaling and NHEJ and HR by direct inhibition of DNA-PK. The mechanistic data not only provide selection of potential pharmacodynamic (PD) markers but also support CC-115 clinical development in patients with ATM-deficient tumors.
Design and Implementation of a Floating Point ALU on a STRATIX-III FPGA (2012)

In this paper, the implementation of DSP modules such as a floating point ALU are presented and designed. The design is based on high performance FPGA "STRATIX III". The implementation is done after functional and timing simulation. The simulation tool used is Model Sim. The tool for synthesis and implementation is QuartusII The experimental results shows the functional and timing analysis for the fixed point to floating converter DSP module carried out using high performance synthesis software from Altera[1]. One of the most important stages of fixed-point to floatingpoint conversion is the evaluation of the floating-point specification accuracy. This evaluation is required to optimize the data word-length according to accuracy constraints. Classical methods for accuracy evaluation are based on floating-point simulations but they lead to very long optimization times. The use of this method in data wordlength minimization processes reduces significantly the optimization time.
Virtual photon approach of cathodoluminescence and ion-beam induced luminescence of solids (2023)

A novel analysis of cathodoluminescence (CL) and ion-beam induced luminescence (IBIL) is presented on the basis of virtual photon spectra (VPS) produced by charged particles (electrons or ions) passing by luminescent species such as defects or impurities, in wide band-gap ionic-covalent solids. A discussion is provided for irradiations in a wide range of charged particle kinetic energy by using the Weizsäcker-Williams theory. The computed VPS are found to decay rapidly as a function of virtual photon (VP) energy regardless of particle energy, for close or distant collisions. The electron-energy dependence of experimental CL spectra of sapphire (<i>α</i>-Al<sub>2</sub>O<sub>3</sub>) is discussed in relation to the computed VPS for the primary and secondary electrons. The experimental IBIL spectra of<i>α</i>-Al<sub>2</sub>O<sub>3</sub>are also analyzed in this framework for protons and helium ions in the MeV energy range. The variations of stopping power are consistent with the variation of the number of emitted VPs. The decay of IBIL yield versus ion stopping power is discussed on the basis of the variation of the computed VPS, and ionization and excitation induced by primary ions and secondary electrons. This decay is accounted for by a decrease of the yield of low-energy secondary electrons with the subsequent VP emission.
Autonomous navigation of underwater vehicles (2002)

The goal of the work is to propose a method to solve with visual means the problem of underwater navigation of an autonomous vehicle moving in deep sea in order to perform inspection of a pipe positioned near the ocean floor. We refer to the ability of an autonomous system to determine its motion with respect to the environment. It is well known that a significant amount of useful information about 3D motion can be obtained from 3D image motion resulting from the projection on the image plane of the camera and 3D objects movements. The method we propose is based on analysis of robust features, extracted from the sequence images, and correspondences between them estimated by applying a method relying only on geometrical invariants. The proposed matching approach consists of an optimization process based on satisfaction of global constraints derived from projective invariance of the cross ratio of any subset of five coplanar points. We match relational graphs characterized by feature-nodes connected by five-order links weighted by cross-ratio values through a nonlinear relaxation labeling process involving high order compatibility measurements.
The Alternative TrkAIII Splice Variant Targets the Centrosome and Promotes Genetic Instability (2009)

The hypoxia-regulated alternative TrkAIII splice variant expressed by human neuroblastomas exhibits oncogenic potential, driven by in-frame exon 6 and 7 alternative splicing, leading to omission of the receptor extracellular immunoglobulin C(1) domain and several N-glycosylation sites. Here, we show that the TrkAIII oncogene promotes genetic instability by interacting with and exhibiting catalytic activity at the centrosome. This function depends upon intracellular TrkAIII accumulation and spontaneous interphase-restricted activation, in cytoplasmic tyrosine kinase (tk) domain orientation, predominantly within structures that closely associate with the fully assembled endoplasmic reticulum intermediate compartment and Golgi network. This facilitates TrkAIII tk-mediated binding of gamma-tubulin, which is regulated by endogenous protein tyrosine phosphatases and geldanamycin-sensitive interaction with Hsp90, paving the way for TrkAIII recruitment to the centrosome. At the centrosome, TrkAIII differentially phosphorylates several centrosome-associated components, increases centrosome interaction with polo kinase 4, and decreases centrosome interaction with separase, the net results of which are centrosome amplification and increased genetic instability. The data characterize TrkAIII as a novel internal membrane-associated centrosome kinase, unveiling an important alternative mechanism to "classical" cell surface oncogenic receptor tk signaling through which stress-regulated alternative TrkAIII splicing influences the oncogenic process.
ChemInform Abstract: Condensation of 2‐Methylbenzoxazole with Aromatic Aldehydes Bearing Acidic Protons. A Convenient Coupling in the Synthesis of the HIV‐ Reverse Transcriptase Inhibitor L‐696,229. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Performance optimization of a de-centralized task allocation protocol via bandwidth and buffer management (2004)

Sharing the resources among various users and the lack of a centralized control are two key characteristics of many distributed heterogeneous computing systems. A critical challenge for designing applications in such systems is to coordinate the resources in a decentralized fashion while adapting to the changes in the system. In this paper, we consider the computation of a large set of equal-sized independent tasks. This represents the computation paradigm for a variety of large scale applications such as SETI@home and Monte Carlo simulations. We focus on the performance optimization for a decentralized adaptive task allocation protocol. We develop a bandwidth allocation strategy based on our decentralized task allocation algorithm, and a simple task buffer management policy. Simulation results show that our task allocation protocol achieves close to the optimal system throughput.
Comparison of self-reported and accelerometer-assessed measurements of physical activity according to socio-demographic characteristics in Korean adults (2018)

We found a low correlation between self-reported and accelerometer-assessed PA among healthy Korean adults, and the correlation decreased with age and depression score. When studying PA using accelerometers and/or questionnaires, age and depression need to be considered, as should differences between self-reported and accelerometer-assessed PA.
Dr. Peter McBride (1946)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
An Utterance Verification System for Word Naming Therapy in Aphasia (2020)

Anomia (word finding difficulties) is the hallmark of aphasia an acquired language disorder, most commonly caused by stroke.Assessment of speech performance using pijcture naming tasks is therefore a key method for identification of the disorder and monitoring patient's response to treatment interventions.Currently, this assessment is conducted manually by speech and language therapists (SLT).Surprisingly, despite advancements in ASR and artificial intelligence with technologies like deep learning, research on developing automated systems for this task has been scarce.Here we present an utterance verification system incorporating a deep learning element that classifies 'correct'/'incorrect' naming attempts from aphasic stroke patients.When tested on 8 native British-English speaking aphasics the system's performance accuracy ranged between 83.6% to 93.6%, with a 10 fold cross validation mean of 89.5%.This performance was not only significantly better than one of the leading commercially available ASRs (Google speech-to-text service) but also comparable in some instances with two independent SLT ratings for the same dataset.
Severe Pulmonary Toxicity in Patients With Advanced-Stage Hodgkin's Disease Treated With a Modified Bleomycin, Doxorubicin, Cyclophosphamide, Vincristine, Procarbazine, Prednisone, and Gemcitabine (BEACOPP) Regimen Is Probably Related to the Combination of Gemcitabine and Bleomycin: A Report of the German Hodgkin's Lymphoma Study Group (2004)

The substitution of etoposide by gemcitabine in the escalated BEACOPP schema is not feasible and leads to severe pulmonary toxicity. This toxicity is probably related to the concomittant application of gemcitabine and bleomycin.
Attenuation by Reactive Oxygen Species of Glucocorticoid Suppression on Proopiomelanocortin Gene Expression in Pituitary Corticotroph Cells (2003)

Up-regulation of hypothalamo-pituitary-adrenal axis is maintained during acute inflammation and/or infection, in the face of sustained elevation of plasma glucocorticoid hormone. Inflammatory stress is usually associated with high plasma cytokine levels and increased generation of reactive oxygen species (ROS) as well. In this study, we examined the effect of ROS on the negative feedback regulation of glucocorticoid in hypothalamo-pituitary-adrenal axis using AtT20 corticotroph cells in vitro. When the cells were treated with H2O2, glucocorticoid suppression on the proopiomelanocortin gene promoter activity was attenuated in a dose-dependent manner. H2O2 also inhibited the ligand-stimulated nuclear translocation of glucocorticoid receptor. The released glucocorticoid suppression by H2O2 was not observed when the cells were cotreated with antioxidants. Together, these results suggest that increased ROS generation in the oxidative redox state attenuates the glucocorticoid negative feedback system, at least in part, by interfering with the nuclear translocation of glucocorticoid receptor and eliminating the repression on proopiomelanocortin gene expression.
Conformational Ensembles of Noncoding Elements in the SARS-CoV-2 Genome from Molecular Dynamics Simulations (2021)

The 5' untranslated region (UTR) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome is a conserved, functional and structured genomic region consisting of several RNA stem-loop elements. While the secondary structure of such elements has been determined experimentally, their three-dimensional structures are not known yet. Here, we predict structure and dynamics of five RNA stem loops in the 5'-UTR of SARS-CoV-2 by extensive atomistic molecular dynamics simulations, more than 0.5 ms of aggregate simulation time, in combination with enhanced sampling techniques. We compare simulations with available experimental data, describe the resulting conformational ensembles, and identify the presence of specific structural rearrangements in apical and internal loops that may be functionally relevant. Our atomic-detailed structural predictions reveal a rich dynamics in these RNA molecules, could help the experimental characterization of these systems, and provide putative three-dimensional models for structure-based drug design studies.
Long-Term Search Through Energy Efficiency and Harvesting (2013)

We study a search problem motivated by our ongoing work on finding radio-tagged invasive fish with an Autonomous Surface Vehicle (ASV). We focus on settings where the fish tend to move along the boundary of a lake. This setting allows us to formulate the problem as a one-dimensional search problem in which the searcher chooses between station keeping and moving so as to maximize the probability of finding the target in a given amount of time without violating its energy-budget. We model the movement of the target as a random-walk and present a closed-form solution for this search problem. Next, we investigate how long-term autonomy can be enabled by energy harvesting. In this case, the search strategy should incorporate the amount of solar energy available at a particular location and particular time. We show how this quantity can be predicted by estimating the geometry of the tree line along the shore. We then obtain the optimal strategy which maximizes the probability of finding the target by formulating the problem as finding the optimal strategy for a Markov Decision Process. Data collected from field experiments validate our approach. 1
Development of printed and flexible dry ECG electrodes (2018)

Printed, flexible and wearable dry electrodes for monitoring electrocardiogram (ECG) signals, without any skin preparation and use of wet gel, has been developed. Silver (Ag) flake ink was screen printed on a flexible polyethylene terephthalate (PET) substrate to fabricate the dry ECG electrode. Multi-walled carbon nanotube (MWCNT)/polydimethylsiloxane (PDMS) composite, as a conductive polymer, was then deposited on the printed Ag electrode by using a bar coating technique. The performance of the printed electrodes was investigated by testing the MWCNT/PDMS composite conductivity and measuring the electrode-skin impedance for electrode radii varying from 8 mm to 16 mm. It was observed that the dry ECG electrode, with the largest area, demonstrated better performance, in terms of MWCNT/PDMS composite conductivity, ECG signal intensity and correlation when compared to a commercial wet silver/silver chloride (Ag/AgCl) electrode. In addition, the capability of the dry ECG electrodes for monitoring ECG signals in both the relaxed sitting position and while the subject is in motion, was also investigated and the results were compared with a wet Ag/AgCl ECG electrode (T716). While the subject is in motion, the printed dry electrodes were less noisy and were able to better identify the typical ECG characteristics in the signals due to its better conformal contact at the electrode-skin interface. The results obtained demonstrated the feasibility of employing conventional screen printing process for the development of flexible dry ECG electrodes for applications in the biomedical industry. Keywords: Dry ECG electrode, ECG monitoring, MWCNT, PDMS, Screen printing, Wearable biomedical sensors
Checkpointing and recovery for distributed shared memory applications (2002)

The paper proposes an approach for adding fault tolerance, based on consistent checkpointing, to distributed shared memory applications. Two different mechanisms are presented to efficiently address the issue of message losses due to either site failures or unreliable non-FIFO channels. Both guarantee a correct and efficient recovery from a consistent distributed system state following a failure. A variant of the two-phase commit protocol is employed such that the communication overhead required to take a consistent checkpoint is the same as that of systems using a one-phase commit protocol, while our protocol utilises stable storage more efficiently. A consistent checkpoint is committed when the first phase of the protocol finishes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Reconfigurable CMOS image sensor design with built-in correlated double sampling (2009)

We propose a CMOS image sensor pixel readout method that eliminates the need for external correlated double sampling circuit that is used in existing CMOS active pixel sensor (APS) design. The pixel transistor count in the proposed design is equal to the standard APS thus retaining high fill factor. The design employs reconfigurable differential-input readout amplifier that may be used in both the reset and the readout phases of the image sensor operation. In the proposed method, the DC offset is removed, flicker noise is differentiated, and reset noise is greatly reduced by employing the amplifier in an active reset configuration. Gain related fixed pattern noise (FPN) is also reduced by higher open-loop gain of the differential amplifier. We present analysis and simulations of the proposed reconfigurable active pixel sensor (RAPS) design in a standard 0.35 mum CMOS process operating from a 3.3 V power supply.
Cerebral blood flow changes in limbic regions induced by unsolvable anagram tasks (1996)

A limbic network integrating negative emotion and cognition seems reflected in reciprocal diencephalic and limbic activation with solvable and unsolvable anagrams. Since unsolvable anagrams have been used to induce learned helplessness in humans, this finding may provide an initial step toward clarifying its neural substrate.
A prospective study of aromatase inhibitor‐associated musculoskeletal symptoms and abnormalities on serial high‐resolution wrist ultrasonography (2010)

Clinically relevant musculoskeletal symptoms develop in women treated with AIs, leading to treatment discontinuation in a substantial percentage of these patients. However, in the current study, patient-reported symptoms were not found to be associated with changes visible on wrist ultrasonography.
CHEMICAL REACTIONS OF ELECTRON DONOR-ACCEPTOR SYSTEM: ON THE MECHANISM OF TRICYANOVINYLATION REACTION OF AROMATIC AMINES WITH TETRACYANOETHYLENE (1974)

Abstract A new mechanism has been proposed for the tricyanovinylation reaction of aromatic amines with tetracyanoethylene.
Tracking Sparse Movement from Fourier Intensity Measurements (2012)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Y. Shechtman, H. Dana, S. Shoham, Y. C. Eldar, O. Cohen, and M. Segev, "Tracking Sparse Movement from Fourier Intensity Measurements," in Frontiers in Optics 2012/Laser Science XXVIII, OSA Technical Digest (online) (Optica Publishing Group, 2012), paper FTu5E.3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article