gebhart/patrepeval huggingface dataset:
Tensile Strength of Compacted Clays during Desiccation under Elevated Temperatures (2021)

ABSTRACT The tensile strength of unsaturated soils is a critical factor controlling the initiation and propagation of desiccation cracks, which can threaten the structural integrity of natural and man-made earthen structures and slopes. Several engineering applications involve unsaturated soils subjected to elevated temperatures (e.g., earthen structure-atmospheric interaction under prolonged droughts, nuclear water disposal, energy piles, ground source heat pumps). Although the temperature dependency of desiccation cracking is demonstrated in the literature, critical gaps remain regarding the characterization of the tensile strength under elevated temperatures. The main objective of this study is to investigate the effect of elevated temperature on the tensile strength of unsaturated clays during desiccation. To accomplish this objective, a novel testing setup that can be used to directly determine soil tensile strength during desiccation was placed in an oven to measure the tensile strength of two compacted clayey soils of medium to high plasticity under different temperatures ranging from 20°C to 60°C. The clays are compacted at 95 % of their respective maximum dry unit weights over a range of water contents from dry to wet of optimum to investigate the influence of initial water content on tensile strength. The results demonstrated that the tensile strength decreased with increasing temperature. At the optimum water content, a tensile strength reduction of 36 % and 27 % in the highly plastic clay and the medium plastic clay, respectively, was observed when the temperature increased from 20°C to 60°C. Additionally, for the partially saturated condition, the initial water content affected the tensile strength significantly. Temperature-induced changes in key factors contributing to the tensile strength of unsaturated clays are discussed to provide further insight into tensile strength of clays at elevated temperatures. The findings of this study can contribute toward a more realistic analysis and design of earthen structures subjected to elevated temperatures.
Vascular Endothelial Growth Factor-mediated Induction of Manganese Superoxide Dismutase Occurs through Redox-dependent Regulation of Forkhead and IκB/NF-κB (2004)

The mitochondrial antioxidant manganese superoxide dismutase (Mn-SOD) plays a critical cytoprotective role against oxidative stress. Vascular endothelial growth factor (VEGF) was shown previously to induce expression of Mn-SOD in endothelial cells by a NADPH oxidase-dependent mechanism. The goal of the current study was to determine the transcriptional mechanisms underlying this phenomenon. VEGF resulted in protein kinase C-dependent phosphorylation of IkappaB and subsequent translocation of p65 NF-kappaB into the nucleus. Overexpression of constitutively active IkappaB blocked VEGF stimulation of Mn-SOD. In transient transfection assays, VEGF increased Mn-SOD promoter activity, an effect that was dependent on a second intronic NF-kappaB consensus motif. In contrast, VEGF-mediated induction of Mn-SOD was enhanced by the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and by dominant negative Akt and was decreased by constitutively active Akt. Overexpression of a constitutively active (phosphorylation-resistant) form of FKHRL1 (TMFKHRL1) resulted in increased Mn-SOD expression, suggesting that the negative effect of PI3K-Akt involves attenuation of forkhead activity. In co-transfection assays, the Mn-SOD promoter was transactivated by TMFKHRL1. Flavoenzyme inhibitor, diphenyleneiodonium (DPI), and antisense oligonucleotides against p47phox (AS-p47phox) inhibited VEGF stimulation of IkappaB/NF-kappaB and forkhead phosphorylation, supporting a role for NADPH oxidase activity in both signaling pathways. Like VEGF, hepatocyte growth factor (HGF) activated the PI3K-Akt-forkhead pathway. However, HGF-PI3K-Akt-forkhead signaling was insensitive to diphenyleneiodonium and AS-p47phox. Moreover, HGF failed to induce phosphorylation of IkappaB/NF-kappaB or nuclear translocation of NF-kappaB and had no effect on Mn-SOD expression. Together, these data suggest that VEGF is uniquely coupled to Mn-SOD expression through growth factor-specific reactive oxygen species (ROS)-sensitive positive (protein kinase C-NF-kappaB) and negative (PI3K-Akt-forkhead) signaling pathways.
Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy (2020)

Protein degraders, also known as proteolysis targeting chimeras (PROTACs), are bifunctional small molecules that promote cellular degradation of a protein of interest (POI). PROTACs act as molecular mediators, bringing an E3 ligase and a POI into proximity, thus promoting ubiquitination and degradation of the targeted POI. Despite their great promise as next-generation pharmaceutical drugs, the development of new PROTACs is challenged by the complexity of the system, which involves binary and ternary interactions between components. Here, we demonstrate the strength of native mass spectrometry (nMS), a label-free technique, to provide novel insight into PROTAC-mediated protein interactions. We show that nMS can monitor the formation of ternary E3-PROTAC-POI complexes and detect various intermediate species in a single experiment. A unique benefit of the method is its ability to reveal preferentially formed E3-PROTAC-POI combinations in competition experiments with multiple substrate proteins, thereby positioning it as an ideal high-throughput screening strategy during the development of new PROTACs.
Rapid, Label-Free, Electrical Whole Blood Bioassay Based on Nanobiosensor Systems (2011)

Biomarker detection based on nanowire biosensors has attracted a significant amount of research effort in recent years. However, only very limited research work has been directed toward biomarker detection directly from physiological fluids mainly because of challenges caused by the complexity of media. This limitation significantly reduces the practical impact generated by the aforementioned nanobiosensors. In this study, we demonstrate an In(2)O(3) nanowire-based biosensing system that is capable of performing rapid, label-free, electrical detection of cancer biomarkers directly from human whole blood collected by a finger prick. Passivating the nanowire surface successfully blocked the signal induced by nonspecific binding when performing active measurement in whole blood. Passivated devices showed markedly smaller signals induced by nonspecific binding of proteins and other biomaterials in serum and higher sensitivity to target biomarkers than bare devices. The detection limit of passivated sensors for biomarkers in whole blood was similar to the detection limit for the same analyte in purified buffer solutions at the same ionic strength, suggesting minimal decrease in device performance in the complex media. We then demonstrated detection of multiple cancer biomarkers with high reliability at clinically meaningful concentrations from whole blood collected by a finger prick using this sensing system.
Personalized Security Indicators to Detect Application Phishing Attacks\n in Mobile Platforms (2015)

Phishing in mobile applications is a relevant threat with successful attacks\nreported in the wild. In such attacks, malicious mobile applications masquerade\nas legitimate ones to steal user credentials. In this paper we categorize\napplication phishing attacks in mobile platforms and possible countermeasures.\nWe show that personalized security indicators can help users to detect phishing\nattacks and have very little deployment cost. Personalized security indicators,\nhowever, rely on the user alertness to detect phishing attacks. Previous work\nin the context of website phishing has shown that users tend to ignore the\nabsence of security indicators and fall victim of the attacker. Consequently,\nthe research community has deemed personalized security indicators as an\nineffective phishing detection mechanism.\n We evaluate personalized security indicators as a phishing detection solution\nin the context of mobile applications. We conducted a large-scale user study\nwhere a significant amount of participants that used personalized security\nindicators were able to detect phishing. All participants that did not use\nindicators could not detect the attack and entered their credentials to a\nphishing application. We found the difference in the attack detection ratio to\nbe statistically significant. Personalized security indicators can, therefore,\nhelp phishing detection in mobile applications and their reputation as an\nanti-phishing mechanism should be reconsidered.\n We also propose a novel protocol to setup personalized security indicators\nunder a strong adversarial model and provide details on its performance and\nusability.\n
Single-Stage Hybrid Energy Storage Integration in Electric Vehicles Using Vector Controlled Power Sharing (2020)

The dual inverter topology driving an open-winding motor is well known in high voltage motor drive applications. This structure allows two energy sources to be directly connected to an open-winding motor. This enables the integration of supercapacitors into a battery electric vehicle (EV). Unlike existing solutions, this article demonstrates dynamic power sharing between the dual energy sources by controlling the active and reactive voltages of the twin inverters, thus enabling the use of the supercapacitor for either active power assist and/or reactive power assist. The dedicated vector-controlled power sharing method and energy management is shown to achieve power sharing in the dual inverter drive integrating a battery and supercapacitor, thereby eliminating the need for an additional cascaded dc/dc converter to extract/supply energy to the supercapacitor. It also enables improved efficiency by eliminating switching losses in the supercapacitor inverter during low power operation. The proposed voltage vector splitting method is also shown to achieve battery-to-supercapacitor power exchange for regulating the net energy in the supercapacitor without affecting motor operation. A laboratory prototype utilizing a 110-kW liquid-cooled EV motor and supercapacitor bank is developed to verify the practical implementation of the power and energy management strategy.
Sensory perception and consumer acceptance of commercial and salt-reduced potato crisps formulated using salt reduction design rules (2022)

Successful salt (NaCl) reduction strategies are required to reduce the salt content of snacks while maintaining saltiness perception and consumer acceptance. Previous research suggests that particle physicochemical design rules (small particle size, low density, low hydrophobicity, optimised particle shape) can be leveraged to produce salt particles that enhance saltiness perception. This study aimed to validate these design rules by applying optimised model salts to unsalted potato crisps at a 30% reduced salt content to produce prototype products. A selection of commercial products were also chosen to represent the salt content and crisp style of the broader market, with the aim to investigate the potential of other salt reduction strategies including; direct salt removal without compensation for loss of salt content and increasing time in mouth, while exploring the impact of consumer mouth behaviour type on consumer product preference. Nine products varying in salt content (6 standard, 1 crinkle-cut, 1 thick-cut batch-fried, 1 baked reconstituted potato) were subject to descriptive sensory analysis with a trained panel (n = 11). A subset (seven products) were assessed for consumer acceptance (n = 93). A salt reduction of 30% was achieved while maintaining saltiness perception and consumer acceptance using model salts, while direct removal of salt without perceptual impact was only achievable by 15%. To investigate key drivers of liking, consumers were segmented based on product liking and mouth behaviour. Results suggested that whilst salt content was the primary driver, specific texture profiles were polarising. However, mouth behaviour had minimal influence on preference. These results validate previously described physicochemical design rules for developing novel salt particles for salt reduction and inform ingredient design for the food and flavour industries.
Cerebellar abnormalities in Huntington's disease: A role in motor and psychiatric impairment? (2014)

The cerebellum has received limited attention in Huntington's disease (HD), despite signs of possible cerebellar dysfunction, including motor incoordination and impaired gait, which are currently attributed to basal ganglia atrophy and disrupted fronto-striatal circuits. This study is the first to investigate a potential contribution of macro- and microstructural cerebellar damage to clinical manifestations of HD. T1- and diffusion-weighted 3T magnetic resonance imaging (MRI) scans were obtained from 12 controls and 22 early-stage HD participants. Manual delineation and voxel-based morphometry were used to assess between-group differences in cerebellar volume, and diffusion metrics were compared between groups within the cerebellar gray and white matter. Associations between these imaging measures and clinical scores were examined within the HD group. Reduced paravermal volume was detected in HD compared with controls using voxel-based morphometry (P < 0.05), but no significant volumetric differences were found using manual delineation. Diffusion abnormalities were detected in both cerebellar gray matter and white matter. Smaller cerebellar volumes, although not significantly reduced, were significantly associated with impaired gait and psychiatric morbidity and of borderline significance with pronate/supinate-hand task performance. Abnormal cerebellar diffusion was associated with increased total motor score, impaired saccade initiation, tandem walking, and timed finger tapping. In conclusion, atrophy of the paravermis, possibly encompassing the cerebellar nuclei, and microstructural abnormalities within the cerebellum may contribute to HD neuropathology. Aberrant cerebellar diffusion and reduced cerebellar volume together associate with impaired motor function and increased psychiatric symptoms in stage I HD, potentially implicating the cerebellum more centrally in HD presentation than previously recognized.
Increase of the photosensitivity of undoped poly(methylmethacrylate) under UV radiation at 325 nm (2014)

In this paper we report, for the first time to our knowledge, an increase of the photosensitivity of a microstructured polymer optical fibre (mPOF) made of undoped PMMA due to applied strain during the fabrication of the gratings. In the work, fibre Bragg gratings (FBGs) have been fabricated in undoped PMMA mPOFs with a hexagonal structure of three rings in the inner cladding. Two sets of FBGs were inscribed at two different resonant wavelengths (827 nm and 1562 nm) at different strains using an UV He-Cd laser at 325 nm focused by a lens and scanned over the fibre. We observed an increase of the reflection of the fibre Bragg gratings when the fabrication strain is higher. The photosensitivity mechanism is discussed in the paper along with the chemical reactions that could underlie the mechanism. Furthermore, the resolution limit of the material was investigated.
Application of the System Identification Method to Model the Transient Response of Grounding Plates (2021)

Ground potential rise (GPR) is a crucial factor in the measurement of lightning protection. To quantitatively analyze the GPR when lightning hits the transmission lines or buildings, we need a mathematical model that describes the grounding system. This paper proposes a modeling method for grounding systems based on the curve fitting and system identification methods. We used a 600 mm x 600 mm grounding plate to verify the validity of the proposed modeling method. The valid soil resistivity of the result model created by proposed method ranges from 0.1 Ωm to 2000 Ωm, and the maximum frequency of the adaptable input signal is 8 MHz. The resulting transfer function model can be taken as an electrical component to link with other circuits in most of commercial circuit simulation software.
Morphology and rheological behavior of maltene–polymer blends. I. Effect of partial hydrogenation of poly(styrene‐block‐butadiene‐block‐styrene‐block)‐type copolymers (2009)

Abstract Because of the importance of the maltene–polymer interaction for the better performance of polymer‐modified asphalts, this article reports the effects of the molecular characteristics of two commercial poly(styrene‐ block ‐butadiene‐ block ‐styrene‐ block ) (SBS) polymers and their partially hydrogenated derivatives [poly{styrene‐ block [(butadiene) 1− x –(ethylene‐ co ‐butylene) x ]‐ block ‐styrene‐ block } (SBEBS)] on the morphology and rheological behavior of maltene–polymer blends (MPBs) with polymer concentrations of 3 and 10% (w/w). Each SBEBS and its parent SBS had the same molecular weight and polystyrene block size, but they differed from each other in the composition of the elastomeric block, which exhibited the semicrystalline characteristics of SBEBS. Maltenes were obtained from Ac‐20 asphalt (Pemex, Salamanca, Mexico), and the blends were prepared by a hot‐mixing procedure. Fluorescence microscopy images indicated that all the blends were heterogeneous, with polymer‐rich and maltene‐rich phases. The rheological behavior of the blends was determined from oscillatory shear flow data. An analysis of the storage modulus, loss modulus, complex modulus, and phase angle as a function of the oscillatory frequency at various temperatures allowed us to conclude that the maltenes behaved as pseudohomogeneous viscoelastic materials that could dissipate stress without presenting structural changes; moreover, all the MPBs were more viscoelastic than the neat maltenes, and this depended on both the characteristics and amount of the polymer. The MPBs prepared with SBEBS were more viscoelastic and possessed higher elasticity than those prepared with SBS. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Factors Influencing Stress Corrosion Crack Growth Kinetics (1987)

One of the problems in relation to predicting the rates of defect growth in structures displaying stress corrosion cracking (SCC) is that knowledge relating to realistic stress corrosion crack velocities is very limited. In monotonic slow strain rate tests (SSRTs) taken to total failure at usual strain rates and in tests on precracked specimens at stress intensity factors in excess of KISCC, stress corrosion crack velocities may be appreciably higher than are likely to occur in service, except in the very late stages of crack growth before a service failure. These differences probably develop partly because of differences in the effective crack tip strain rate, and consideration is given to various expressions for calculating the latter from the applied strain rate. For multiple cracked specimens, as in SSRTs, the importance of considering the number of cracks is demonstrated, in which case it is possible to calculate (involving electrochemical data) the crack velocity-strain rate relationships in good agreement with the experimental data without recourse to empirical factors that ensure a good fit. However, another factor must be considered in relation to crack velocities that hitherto has received scant attention. Thus, new cracks continue to be nucleated with the passage of time; these, together with cracks previously initiated and grown, may coalesce or merge to produce larger cracks. Crack coalescence is considered particularly in relation to the later stages of crack growth, in which its role can be critical; however, it is probable that the merging of small cracks may sustain crack growth under circumstances in which crack growth would otherwise cease.
Partial Least Squares: A First‐order Analysis (1998)

We compare the partial least squares (PLS) and the principal component analysis (PCA), in a general case in which the existence of a true linear regression is not assumed. We prove under mild conditions that PLS and PCA are equivalent, to within a first‐order approximation, hence providing a theoretical explanation for empirical findings reported by other researchers. Next, we assume the existence of a true linear regression equation and obtain asymptotic formulas for the bias and variance of the PLS parameter estimator
Efficient GaN tunnel junctions using embedded GdN nanoislands (2012)

We show that GdN nanoislands can enhance inter-band tunneling in GaN PN junctions by several orders of magnitude, enabling low optical absorption low-resistance tunnel junctions (specific resistivity 1.3 X 10-3 {\Omega}-cm2) for various optoelectronic applications. We exploit the ability to overgrow high quality GaN over GdN nanoislands to create new nanoscale heterostructure designs that are not feasible in planar epitaxy. GdN nanoisland assisted inter-band tunneling was found to enhance tunneling in both of the polar orientations of GaN. Tunnel injection of holes was confirmed by low temperature operation of GaN p-n junction with a tunneling contact layer, showing strong electroluminescence down to 20K. The availability of tunnel junctions with negligible absorption could not only improve the efficiency of existing optoelectronic devices significantly, but also enable new electronic and optical devices based on wide band gap materials.
Wolbachiabacteria in filarial immunity and disease (2001)

Lymphatic filarial nematodes are infected with endosymbiotic Wolbachia bacteria. Lipopolysaccharide from these bacteria is the major activator of innate inflammatory responses induced directly by the parasite. Here, we propose a mechanism by which Wolbachia initiates acute inflammatory responses associated with death of parasites, leading to acute filarial lymphangitis and adverse reactions to antifilarial chemotherapy. We also speculate that repeated exposure to acute inflammatory responses and the chronic release of bacteria, results in damage to infected lymphatics and desensitization of the innate immune system. These events will result in an increased susceptibility to opportunistic infections, which cause acute dermatolymphangitis associated with lymphoedema and elephantiasis. The recognition of the contribution of endosymbiotic bacteria to filarial disease could be exploited for clinical intervention by the targeting of bacteria with antibiotics in an attempt to reduce the development of filarial pathology.
Toward a peer-to-peer shared virtual reality (2003)

This paper envisions a shared virtual reality system that could handle millions of users and objects. The SOLIPSIS system does not rely on servers and is based on a network of peers that collaborate to build up a common virtual world. Real-time interactions and virtual co-presence are enabled by the means of emissive and receptive fields that determine how avatar kinestesia and multimedia streams are established. We describe here the overall architecture and the main algorithms that make Soupsis conceivable.
Laboratory and Field Investigations of Bovine Myxovirus Parainfluenza 3 Virus and Vaccine (1961)

Summary A potent formalin-killed vaccine was prepared from bovine kidney cultures infected with the SF-4 strain of Myxovirus parainfluenza 3 virus. The aqueous vaccine was highly potent for guinea pigs when administered by various routes and regularly evoked the formation of neutralizing, HI and CF antibodies. On the other hand, the aqueous vaccine was of insufficient potency to immunize cattle in the dosage employed. Emulsification of the vaccine with Arlacel A-mineral oil adjuvant effected great enhancement of antigenic potency. Such material, in properdosage, evoked high level antibody response in both guinea pigs and bovines. The significance of the findings is discussed.