gebhart/patrepeval huggingface dataset:
Characteristics of Magnetic Properties of Grain-Oriented Silicon Iron with High Permeability (1969)

Grain-oriented silicon iron with high permeability is prepared using aluminum-nitride needles to restrain normal grain growth. The improvements in hysteresis loss of specimens with a permeability of 1920 are about 0.120 W/kg at 15 kG and 0.160 W/kg at 17 kG as compared to the commerical product with a permeability of 1820. That is the reason why the crystal orientation has a strong influence on total loss, especially at B = 17 kG. The effect of grain size on total loss is important also. The detrimental aluminum nitride and aluminum oxide are not present in the base metal after final annealing. For example, aluminum oxide is removed from the base metal and absorbed into a glass film. Glass-type coating plays a dominant role, not only for the magnetostriction, but also for total loss of these specimens with high permeability, especially in thin-gauge specimens.
Characteristics of the Human Host Have Little Influence on Which Local Schistosoma mansoni Populations Are Acquired (2013)

Infection prevalence was 41% for these communities, and the epidemiologic characteristics were similar to many of the endemic areas of Brazil and the world. Parasite population structuring was observed between the two communities (Jost's D 0.046, CI95% 0.042-0.051), although separated by only 8 km and connected by a highway. No structuring was observed when infected individuals were stratified by host's biologic, demographic or epidemiologic characteristics. Those most heavily infected best reflected the communities' overall parasite diversity. The lack of differentiation within villages suggests that individuals are likely to get infected at the same sites or that the same parasite multilocus genotypes can be found at most sites. The geographic structuring between villages and the lack of structuring by age of the host further supports the impression of a population little affected by migration or drift.
X-ray detection properties of plastic scintillators containing surface-modified Bi2O3nanoparticles (2018)

Plastic scintillators containing Bi2O3 nanoparticles (NPs) were developed as detectors for X-ray synchrotron radiation. A hydrothermal method was used to synthesize the NPs that had average particle sizes of less than 10 nm. Higher NP concentration led to a higher detection efficiency at 67.4 keV. The light yield of the scintillator containing 5 wt % Bi2O3 NPs was comparable with or higher than that of the commercially available plastic scintillator, EJ 256. The time resolution of the developed scintillation detector equipped with each sample scintillator was approximately 0.6 ns. Dispersion of nanoparticles within plastic scintillators is generally applicable and has wide application as a method for preparation of plastic scintillators for detecting X-ray synchrotron radiation.
Synthesis of a New Type of Water-Soluble Phosphines by addition of hydrophilic thiols to vinylphosphines. Preparation of the rhodium and palladium complexes (1997)

Commercially available ω-thioalkane sodium sulfonates could easily be added to mono-, bi- and trivinylphosphines. The two-phase system became homogeneous by stirring. The products (1–6, 11) were characterized as phosphinoethyl-sulfonatoalkyl-thioethers with an unexpected high water solubility and with defined P/S ratios from 1/2, 1/4 and 1/6. All thioetherphosphines were characterized by 1H, 13C and 31P NMR spectroscopy, IR spectroscopy and elemental analysis. Addition occurs only at pH > 7 and in the absence of strong electrophiles to avoid the formation of phosphonium compounds. L-Cysteine ethyl ester (8) and 2-aminoethanethiol (9) react exclusively at the thiol group. The first complexes with Pd(II), Rh(III) and Rh(I) show a participation of the thioether group in the coordination.
Hierarchy-Based Image Embeddings for Semantic Image Retrieval (2019)

Deep neural networks trained for classification have been found to learn powerful image representations, which are also often used for other tasks such as comparing images w.r.t. their visual similarity. However, visual similarity does not imply semantic similarity. In order to learn semantically discriminative features, we propose to map images onto class embeddings whose pair-wise dot products correspond to a measure of semantic similarity between classes. Such an embedding does not only improve image retrieval results, but could also facilitate integrating semantics for other tasks, e.g., novelty detection or few-shot learning. We introduce a deterministic algorithm for computing the class centroids directly based on prior world-knowledge encoded in a hierarchy of classes such as WordNet. Experiments on CIFAR-100, NABirds, and ImageNet show that our learned semantic image embeddings improve the semantic consistency of image retrieval results by a large margin.
Synthesis and application of new solid phase techniques in quantitative proteomics using MALDI and ESI mass spectrometry (2008)

Proteomics, the analysis of the protein complement of a cell or an\norganism has grown rapidly as a category of the life sciences. Mass\nspectrometry (MS) is one of the central detection techniques in proteome\nanalysis, yet it has to rely on prior sample preparation steps that reduce the\nenormous complexity of the protein mixtures obtained from biological systems.\nFor that reason, a number of tagging (or labeling) strategies have been\ndeveloped that target specific amino acid residues or post-translational\nmodifications, enabling the enrichment of subfractions via affinity clean up,\nresulting in the identification of an ever-increasing number of proteins. In\naddition, the attachment of stable isotope-labeled tags now allow the relative\nquantitation of protein levels of two samples, e.g. those representing different\ncell states, which is of great significance for drug discovery and molecular\nbiology.\nThis work presents the research for new stable isotope-labeled (as well as\nstable-isotope free) solid phase strategies for the identification and relative\nquantitation of complex protein mixtures using MALDI and ESI-MS, MS/MS\ntechnology.
Capture-ejector satellites (1982)

A satellite in the form of a large rotating rim which can be used to boost spacecraft from low-Earth orbit to higher orbits is described. The rim rotates in the plane of its orbit such that the lower portion of the rim is traveling at suborbital velocity, while the upper portion is travelling at greater than orbital velocity. Ascending spacecraft or payloads arrive at the lowest portion of the rim at suborbital velocities, where the payloads are released on a trajectory for higher orbits; descending payloads employ the reverse procedure. Electric thrusters placed on the rim maintain rim rotational speed and altitude. From the standpoint of currently known materials, the capture-ejector concept may be useful for relatively small velocity increments.
Suppression of fungal growth by isolated trypsin inhibitors of corn grain (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSuppression of fungal growth by isolated trypsin inhibitors of corn grainAbdul H. Halim, Clyde E. Wassom, Howard L. Mitchell, and Leon K. EdmundsCite this: J. Agric. Food Chem. 1973, 21, 6, 1118–1119Publication Date (Print):November 1, 1973Publication History Published online1 May 2002Published inissue 1 November 1973https://pubs.acs.org/doi/10.1021/jf60190a016https://doi.org/10.1021/jf60190a016research-articleACS PublicationsRequest reuse permissionsArticle Views31Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Unusual Chlorination of Some Olefins with meta‐Chloroperbenzoic Acid in Dichloromethane. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Far Cortical Locking Can Reduce Stiffness of Locked Plating Constructs While Retaining Construct Strength (2009)

Far cortical locking significantly reduces the axial stiffness of a locked plating construct. This gain in flexibility causes only a modest reduction in axial strength and increased torsional and bending strength.
Characterization of the Salmonella enterica Two-Component Regulatory System SsrA-SsrB and the SsrB Regulon (2014)

Salmonella enterica is an intracellular bacterial pathogen of humans and the causative agent of the acute gastrointestinal disease, salmonellosis, and the chronic systemic infection, typhoid fever. Sensor proteins convert environmental signals, including signals detected within the host environment, into biochemical signals to control cellular responses. It has been previously established that the two component regulatory system SsrA-SsrB, consisting of the integral membrane sensor kinase protein SsrA and the cytoplasmic DNA-binding response regulator SsrB are essential for regulation of bacterial factors during systemic intracellular infection. The first chapter of this thesis describes characterization of the sensor kinase SsrA. The structure of the periplasmic sensor domain is modeled and evidence is presented that it is involved in enhancing signaling activity in response to environmental acidification encountered within the intracellular environment. A mechanism whereby protonation of histidine residues within this region in response to acidification drives conformational strain and thereby signaling is proposed. The second chapter describes identification of the DNA-binding motif of SsrB within regulated promoters as well as its regulon. Integration of experimental data with comparative genomics data resulted in identification of the palindromic heptameric DNA recognition motif of SsrB as well as identification of novel SsrB-regulated promoters. In addition, a DNA microarray analysis is described wherein the complete SsrB regulon is identified. Finally, the third chapter describes regulatory input of SsrB to the S. enterica type VI secretion system. This chapter also describes the contribution of this system to systemic dissemination of S. enterica during host infection. Altogether, these data advance understanding of how Salmonella controls factors essential for disease in response to the host environment during infection.
The amino acid sequence of the human RNA polymerase II 33-kDa subunit hRPB 33 is highly conserved among eukaryotes. (1990)

We have cloned and sequenced a cDNA of 1766 base pairs in length encoding the 275 amino acids of hRPB 33, the third largest subunit of human RNA polymerase II. The DNA was isolated by screening of a human lambda gt11 cDNA library with oligonucleotides designed on the basis of the amino acid residue analysis of the bovine material. The hRPB 33 amino acid sequence is highly conserved between Saccharomyces cerevisiae and human. Overall, 45% of the amino acid residues are identical with the yeast homologue RPB 3, and 65% of the amino acids are identical in the two major conserved regions at residues 0-103 and 151-197. hRPB 33 is also homologous to yeast RPC 5. The amino acid sequence of hRPB 33 showed no obvious homology with bacterial RNA polymerase or with any of its sigma factors.
Efficient handling of high-dimensional feature spaces by randomized classifier ensembles (2002)

Handling massive datasets is a difficult problem not only due to prohibitively large numbers of entries but in some cases also due to the very high dimensionality of the data. Often, severe feature selection is performed to limit the number of attributes to a manageable size, which unfortunately can lead to a loss of useful information. Feature space reduction may well be necessary for many stand-alone classifiers, but recent advances in the area of ensemble classifier techniques indicate that overall accurate classifier aggregates can be learned even if each individual classifier operates on incomplete "feature view" training data, i.e., such where certain input attributes are excluded. In fact, by using only small random subsets of features to build individual component classifiers, surprisingly accurate and robust models can be created. In this work we demonstrate how these types of architectures effectively reduce the feature space for submodels and groups of sub-models, which lends itself to efficient sequential and/or parallel implementations. Experiments with a randomized version of Adaboost are used to support our arguments, using the text classification task as an example.
Relative Enterotoxigenicity of Coliform Bacteria (1977)

The enterotoxigenicity of 12 strains of coliform bacteria (Enterobacter cloacae, Klebsiella pneumoniae, and Escherichia coli) isolated from the gastrointestinal (GI) tract of persons with either acute diarrhea or tropical sprue and of 13 strains of the same species isolated from urine (GU) cultures was determined. Fractions of heat-labile (LT) and heat-stable (ST) toxins of each strain were separated by ultrafiltration, and the effect of graded concentrations (range, 100 microgram-10 pg/ml) on water transport was assessed by in vivo perfusion in the rat jejunum. Enterotoxigenic activity was defined as inducement of net secretion of water. All 12 of the GI strains and six of 13 GU strains elaborated enterotoxins, but there was a millionfold quantitative difference in the potency of the toxins produced. All of the GI strains produced one or both forms of toxin, which had a minimal effective concentration of as low as 0.1-10 ng/ml, whereas the GU strains produced toxins of weak or, rarely, of intermediate potency.
Dynamic Spectrum Access in the Time Domain: Modeling and Exploiting White Space (2007)

Dynamic spectrum access is a promising approach to alleviate the spectrum scarcity that wireless communications face today. In short, it aims at reusing sparsely occupied frequency bands while causing no (or insignificant) interference to the actual licensees. This article focuses on applying this concept in the time domain by exploiting idle periods between bursty transmissions of multi-access communication channels and addresses WLAN as an example of practical importance. A statistical model based on empirical data is presented, and it is shown how to use this model for deriving access strategies. The coexistence of Bluetooth and WLAN is considered as a concrete example.
Four-year follow-up from a phase 2 study of obinutuzumab, ibrutinib, and venetoclax in CLL. (2022)

7540 Background: Targeted agent combinations for chronic lymphocytic leukemia (CLL) have resulted in safe regimens with improved progression-free survival (PFS) compared to chemoimmunotherapy. The optimal regimen and long-term outcomes remain unknown. We conducted a phase 2 study of obinutuzumab (OBIN), ibrutinib (IBR), and venetoclax (VEN) in relapsed/refractory (RR) and treatment-naïve (TN) CLL patients (pts) and report extended follow up on two previously reported cohorts (RR, TN 1) and a new cohort of identically treated TN pts (TN 2). Methods: Pts with TN or RR (≥1 prior treatment) CLL requiring treatment were eligible. Treatment was given for 14 28-day cycles (C). OBIN was started C1, IBR C2, and VEN C3 with standard dose escalation. Response was assessed 2 months (mos) after C14 (EOT) by iwCLL 2008 criteria. Minimal residual disease (MRD) was measured by 10-color flow cytometry with a cutoff of &lt; 1x10 -4 . The primary endpoint was complete remission (CR) with undetectable MRD (uMRD) in blood and bone marrow at EOT. A sample size of 25 pts per cohort achieves 90% power to test the null hypothesis of 10% against 30% with 1-sided α of 10%. The Kaplan-Meier method was used to estimate PFS and overall survival (OS). Results: 75 pts were treated in 3 cohorts (Table). Data are as of 1/3/2022. In the TN 2 cohort, the overall response rate (ORR) at EOT was 96% (95% CI: 80-100) and CR with uMRD was 20% (95% CI: 7-41). The ORR for TN 1 and TN 2 combined was 90% (95% CI: 78-97) and CR with uMRD was 24% (95% CI: 13-38). Median follow up was 56 (0-65), 57 (7-63), and 30 (24-35) mos, respectively, for RR, TN 1, and TN 2. There were 3 deaths (RR = 1, TN 1 = 1, TN 2 = 1) and 6 disease progressions (RR = 4, TN 1 = 2, TN 2 = 0). Estimated 48-month PFS for TN 1 and RR cohorts were both 96% (95% CI: 72-99) and OS was 85% (95% CI: 60-95) and 100%, respectively. The estimated 24-month PFS and OS for TN 2 were both 96% (95% CI: 75-99). The most frequent adverse events were neutropenia (95%, 73% grade ≥3), leukopenia (95%, 45% grade ≥3), lymphopenia (93%, 40% grade ≥3), and thrombocytopenia (91%, 28% grade ≥3). The only grade ≥3 non-hematologic toxicity occurring at ≥20% was hypertension (85%, 39% grade ≥3). Atrial fibrillation occurred in 11% of pts. Conclusions: At extended follow-up, remissions remain durable after fixed duration OBIN, IBR, and VEN. The efficacy and acceptable safety justify further study and are being compared to IBR and OBIN in 2 phase 3 US cooperative group trials. Clinical trial information: NCT02427451. [Table: see text]
Oscillatory Behavior in Electrochemical Deposition Reaction of Polycrystalline Silicon Thin Films through Reduction of Silicon Tetrachloride in a Molten Salt Electrolyte (1996)

Abstract A new electrochemical oscillation is found for reduction reaction of silicon tetrachloride on a partially immersed single crystal n-Si electrode in a lithium chloride-potassium chloride eutectic melt electrolyte. The reduction of SiCl4, which is almost insoluble in the electrolyte, occurs mainly near the upper edge of an electrolyte meniscus on the electrode, and it is discussed that the oscillation is caused by a change in the height of the meniscus due to a change in the chemical structure (and hence the interfacial tension) of the electrode surface with progress of the silicon deposition reaction.
The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate (2003)

The phosphorylated carboxyl-terminal "tail" domains of the neurofilament (NF) subunits, NF heavy (NF-H) and NF medium (NF-M) subunits, have been proposed to regulate axon radial growth, neurofilament spacing, and neurofilament transport rate, but direct in vivo evidence is lacking. Because deletion of the tail domain of NF-H did not alter these axonal properties (Rao, M.V., M.L. Garcia, Y. Miyazaki, T. Gotow, A. Yuan, S. Mattina, C.M. Ward, N.S. Calcutt, Y. Uchiyama, R.A. Nixon, and D.W. Cleveland. 2002. J. Cell Biol. 158:681-693), we investigated possible functions of the NF-M tail domain by constructing NF-M tail-deleted (NF-MtailDelta) mutant mice using an embryonic stem cell-mediated "gene knockin" approach that preserves normal ratios of the three neurofilament subunits. Mutant NF-MtailDelta mice exhibited severely inhibited radial growth of both motor and sensory axons. Caliber reduction was accompanied by reduced spacing between neurofilaments and loss of long cross-bridges with no change in neurofilament protein content. These observations define distinctive functions of the NF-M tail in regulating axon caliber by modulating the organization of the neurofilament network within axons. Surprisingly, the average rate of axonal transport of neurofilaments was unaltered despite these substantial effects on axon morphology. These results demonstrate that NF-M tail-mediated interactions of neurofilaments, independent of NF transport rate, are critical determinants of the size and cytoskeletal architecture of axons, and are mediated, in part, by the highly phosphorylated tail domain of NF-M.
HCV upregulates Bim through the ROS/JNK signalling pathway, leading to Bax-mediated apoptosis (2015)

We previously reported that hepatitis C virus (HCV) infection induces Bax-triggered, mitochondrion-mediated apoptosis by using the HCV J6/JFH1 strain and Huh-7.5 cells. However, it was still unclear how HCV-induced Bax activation. In this study, we showed that the HCV-induced activation and mitochondrial accumulation of Bax were significantly attenuated by treatment with a general antioxidant, N-acetyl cysteine (NAC), or a specific c-Jun N-terminal kinase (JNK) inhibitor, SP600125, with the result suggesting that the reactive oxygen species (ROS)/JNK signalling pathway is upstream of Bax activation in HCV-induced apoptosis. We also demonstrated that HCV infection transcriptionally activated the gene for the pro-apoptotic protein Bim and the protein expression of three major splice variants of Bim (BimEL, BimL and BimS). The HCV-induced increase in the Bim mRNA and protein levels was significantly counteracted by treatment with NAC or SP600125, suggesting that the ROS/JNK signalling pathway is involved in Bim upregulation. Moreover, HCV infection led to a marked accumulation of Bim on the mitochondria to facilitate its interaction with Bax. On the other hand, downregulation of Bim by siRNA (small interfering RNA) significantly prevented HCV-mediated activation of Bax and caspase 3. Taken together, these observations suggest that HCV-induced ROS/JNK signalling transcriptionally activates Bim expression, which leads to Bax activation and apoptosis induction.
Interaction of holes in a Hubbard antiferromagnet and high-temperature superconductivity (1988)

The ${\mathrm{CuO}}_{2}$ planes in the high-temperature superconductors are described by a two-dimensional Hubbard model. The model is investigated for an infinite system with one and two electrons less than half filling. The method used is to diagonalize the Hamiltonian exactly within a retained portion of the Hilbert space. A single hole is found not to be localized by a string potential that increases linearly with distance, although it does have a large effective mass. A pair of holes, which naively should be quite mobile, is found instead to be extremely heavy due to a previously unappreciated frustration effect that impedes their motion. This lack of mobility increases the energy of the pair so that they do not bind, contrary to some recently published results using mean field theory or intuitive arguments. The energy of one- and two-hole states is calculated as a function of wavevector k. The comparative energy of different angular momentum channels and magnetic polaron effects are discussed.
Purification and Immunochemical Characterization of Human Plasma Factor XIII (1976)

A detailed study of the conditions for purification of plasma factor XIII was undertaken and an optimal procedure developed. This procedure involves adsorption with aluminum hydroxide, repeated fractionation with ammonium sulfate, heat denaturation of fibrinogen, precipitation with polyethylene glycol, cryoprecipitation, and chromatography on DEAE-cellulose with gradient elution. The specific activity of the final product, as measured by the fluorescent amine incorporation assay for factor XIII, averages about 3,000-4,000 mumol dansylcadaverine incorporation/mg protein. The yield is about 20%. In SDS electrophoresis the final product has two bands under nonreducing conditions, characteristic of the a and b subunits.