gebhart/patrepeval huggingface dataset:
FEM1 proteins are ancient regulators of SLBP degradation (2017)

FEM1A, FEM1B, and FEM1C are evolutionarily-conserved VHL-box proteins, the substrate recognition subunits of CUL2-RING E3 ubiquitin ligase complexes. Here, we report that FEM1 proteins are ancient regulators of Stem-Loop Binding Protein (SLBP), a conserved protein that interacts with the stem loop structure located in the 3' end of canonical histone mRNAs and functions in mRNA cleavage, translation and degradation. SLBP levels are highest during S-phase coinciding with histone synthesis. The ubiquitin ligase complex SCF<sup>cyclin F</sup> targets SLBP for degradation in G2 phase; however, the regulation of SLBP during other stages of the cell cycle is poorly understood. We provide evidence that FEM1A, FEM1B, and FEM1C interact with and mediate the degradation of SLBP. Cyclin F, FEM1A, FEM1B and FEM1C all interact with a region in SLBP's N-terminus using distinct degrons. An SLBP mutant that is unable to interact with all 4 ligases is expressed at higher levels than wild type SLBP and does not oscillate during the cell cycle. We demonstrate that orthologues of SLBP and FEM1 proteins interact in C. elegans and D. melanogaster, suggesting that the pathway is evolutionarily conserved. Furthermore, we show that FEM1 depletion in C. elegans results in the upregulation of SLBP ortholog CDL-1 in oocytes. Notably, cyclin F is absent in flies and worms, suggesting that FEM1 proteins play an important role in SLBP targeting in lower eukaryotes.
Enhancing the Phase Stability of Inorganic α-CsPbI3 by the Bication-Conjugated Organic Molecule for Efficient Perovskite Solar Cells (2019)

Inorganic CsPbI<sub>3</sub> perovskite has demonstrated promising potentials for photovoltaic applications, whereas the black perovskite polymorph (α phase) of CsPbI<sub>3</sub> was easily prone to converting into yellow phase (δ phase) under ambient moist environment, which restrained its practical application and further studies severely. In this study, <i>p</i>-phenylenediammonium iodide (PPDI) was employed to posttreat CsPbI<sub>3</sub> films for controlling the phase conversion, strengthening moisture resistance, and improving device performance. The multiple roles of PPDI were as follows: (1) avoiding spontaneous octahedral tilting by ionic bonds between NH<sub>3</sub><sup>+</sup> of PPD<sup>2+</sup> and I<sup>-</sup> of [PbI<sub>6</sub>]<sup>4-</sup>; (2) enhancing the hydrophobicity induced by exactly exposed oil-wet (hydrophobic) benzene rings; and (3) passivating surface defects and filling I vacancies. As a result, after the treatment, mutable a-CsPbI<sub>3</sub> could maintain its α phase for at least 30 d in dry air (<20% RH). The perovskite solar cells with PPDI treatment exhibited reproductive photovoltaic performance with a champion power conversion efficiency (PCE) of 10.4, and 91% of the initial PCE was retained after storage for 504 h in a dark dry box without any encapsulation.
Weight changes before and after lurasidone treatment: a real-world analysis using electronic health records (2017)

Lurasidone was associated with a reduction in weight at 1 year following its initiation in patients with schizophrenia or bipolar disorder. Stratified analyses indicated that weight reduction was more pronounced among patients who had received second-generation antipsychotics associated with a higher risk of weight gain prior to lurasidone treatment. These findings are consistent with the results of prior short- and long-term prospective studies and suggest that lurasidone is associated with low risk for weight gain in patients with schizophrenia or bipolar disorder.
Untersuchung an oxidischen Katalysatoren. XXVI. Die Wirkung modifizierter Mordenite beim formselektiven Spalten von Paraffinen (1978)

Abstract Die Formselektivität des Mordenits beim Spalten von n‐Octan und von iso‐Octan ist in komplexer Weise von der Acidität des Festkörpers, dem Äquivalentgehalt an eingetauschten Kationen, der Verteilung der aktiven Zentren im Mordenit und den Reaktionsbedingungen abhängig. Alle Einflußfaktoren werden durch die langsame Diffusion der verzweigten Kohlenwasserstoffe im Porensystem des Mordenits erklärt.
TWISTER (2002)

TWISTER, (Telexistence Wide-angle Immersive STERe-oscope) is an immersive full-color autostereoscopic display, designed for a face-to-face telecommunication system called "mutual telexistence", where people in distant locations can communicate as if they were in the same virtual three dimensional space.
Electrochemical Intercalation of Magnesium into Graphite Via an Ethylenediamine-Based Electrolyte (2021)

The formation of dimeric or larger cluster metal intercalates within layered hosts may reveal new chemistries for charge storage electrodes. In previous work, we reported a series of novel ternary stage-1 graphite intercalation compounds (GICs) containing alkaline earth metal cations (M = Mg, Ca, Sr, or Ba) and ethylenediamine (en). Pair distribution function (PDF) analyses indicated the presence M-M bonding within the intercalates in the monolayer galleries.
Understanding the Polymorphism of Cobalt Nanoparticles Formed in Electrodeposition─An In Situ XRD Study (2023)

An advanced synchrotron-based in situ X-ray diffraction (XRD) technique is successfully developed and employed to track and monitor the formation and phase selection of cobalt (Co) in electrodeposition in real time and verify DFT computational results. The impacts of a number of controlling factors including the pH of the electrolyte and deposition overpotential are systematically studied. The results show that the yielded phase of the electrodeposited Co is controlled by both thermodynamics and kinetics. The low pH low overpotential condition favors the formation of the thermodynamically stable fcc phase. While the high pH high overpotential condition promotes the formation of the metastable hcp phase. The experimental results agree well with the nanometric phase diagram computed with DFT. Layer-by-layer alternative stacking of fcc-hcp polymorphic phases can be facilely fabricated by just varying the overpotential. This work not only offers an effective means to control the phase of electroplating of Co but also presents a new approach to reveal the fundamental insights of the formation of metals under electrochemical reduction driving force.
Effects of Clenbuterol on Rabbit Vesicourethral Muscle Contractility. (1995)

Clenbuterol (10(-10)-10(-7) M), a selective beta 2-adrenoceptor agonist, reduced spontaneous contractile force of isolated rabbit bladder dome, bladder base and proximal urethra. Clenbuterol inhibited both acetylcholine (Ach)-and electrical field stimulation (EFS)-induced contractions of rabbit bladder dome, but was more potent in inhibiting EFS-than Ach-induced contractions. Acetylcholine-but not EFS-induced contractions in the bladder dome were completely inhibited by pretreatment with 10(-6) M atropine. The atropine resistant component of the EFS-induced contractions was completely inhibited by tetrodotoxin, 10(-6) M. Clenbuterol and a non-selective beta-adrenoceptor agonist, isoproterenol, potentiated the EFS-induced contractions of isolated striated muscle preparations from the external urethral sphincter and from the extensor digitorum longus in the rabbit. Clenbuterol was more potent than isoproterenol in increasing EFS-induced contractile force in the external urethral sphincter, whereas isoproterenol was more potent than clenbuterol in increasing EFS-induced contractile force in the extensor digitorum longus. These data suggest that clenbuterol may have a role in the treatment of urinary incontinence by inhibiting the detrusor contraction and fascilitating the external urethral sphincter selectively.
Diversamente abili in famiglia: educazione e politiche sociali (2006)

Agire sulle dinamiche familiari in base ad un modello pedagogico che recuperi l'antico principio dell'empowerment, potenzia le relazioni insite nel nucleo familiare, poiché ne favorisce la soggettività e aiuta la famiglia, soprattutto in presenza di un soggetto disabile, a rafforzare le sue risorse e il legame con la comunità, consentendole di essere non solo utente privilegiato dei sistemi di welfare, ma anche soggetto attivo delle politiche sociali, perchè riscopre l'antico concetto pedagogico dell'educare inteso come processo di umanizzazione e promozione del benessere umano.
Molecular Characterisation of Bacteriophage K Towards Applications for the Biocontrol of Pathogenic Staphylococci. (2006)

• S. O’Flaherty, Coffey, A., Meaney W., Fitzgerald G.F. and Ross R.P. (2005). Heterologous expression of lysK encoding a lysin with anti-MRSA activity
Mitochondria of Protists (2004)

▪ Abstract Over the past several decades, our knowledge of the origin and evolution of mitochondria has been greatly advanced by determination of complete mitochondrial genome sequences. Among the most informative mitochondrial genomes have been those of protists (primarily unicellular eukaryotes), some of which harbor the most gene-rich and most eubacteria-like mitochondrial DNAs (mtDNAs) known. Comparison of mtDNA sequence data has provided insights into the radically diverse trends in mitochondrial genome evolution exhibited by different phylogenetically coherent groupings of eukaryotes, and has allowed us to pinpoint specific protist relatives of the multicellular eukaryotic lineages (animals, plants, and fungi). This comparative genomics approach has also revealed unique and fascinating aspects of mitochondrial gene expression, highlighting the mitochondrion as an evolutionary playground par excellence.
Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice (2019)

The group III metabotropic glutamate receptor subtype 7 (mGlu7) is an important regulator of glutamatergic and GABAergic neurotransmission and known to mediate emotionality and male social behavior. However, a possible regulatory role in maternal behavior remains unknown to date. Adequate expression of maternal behavior is essential for successful rearing and healthy development of the young. By understanding genetic and neural mechanisms underlying this important prosocial behavior, we gain valuable insights into possible dysregulations. Using genetic ablation as well as pharmacological modulation, we studied various parameters of maternal behavior in two different mouse strains under the influence of mGlu7. We can clearly show a regulatory role of mGlu7 in maternal behavior. Naïve virgin female C57BL/6 mGlu7 knockout mice showed more often nursing postures and less spontaneous maternal aggression compared to their heterozygous and wildtype littermates. In lactating C57BL/6 wildtype mice, acute central activation of mGlu7 by the selective agonist AMN082 reduced arched back nursing and accelerated pup retrieval without affecting maternal aggression. In addition, in lactating CD1 wildtype mice the selective mGlu7 antagonist XAP044 increased both pup retrieval and maternal aggression. With respect to receptor expression levels, mGlu7 mRNA expression was higher in lactating vs virgin C57BL/6 mice in the prefrontal cortex, but not hypothalamus or hippocampus. In conclusion, these findings highlight a significant role of the mGlu7 receptor subtype in mediating maternal behavior in mice. Region-dependent studies are warranted to further extend our knowledge on the specific function of the brain glutamate system in maternal behavior.
Determination of flavor components of rice bran by GC-MS and chemometrics (2012)

The flavor composition of rice bran was investigated using solid-phase microextraction (SPME), which was selected from four extraction methods. Additionally, static headspace extraction (SHS), accelerated solvent extraction (ASE) and simultaneous distillation extraction (SDE), followed by GC-MS analysis with the help of heuristic evolving latent projections (HELP) were also used. The effects of the most important factors, including fiber coating, extraction time, and temperature of SPME, on the flavor components of rice bran were studied. Qualitative analysis of the flavor components was obtained by a mass spectra similarity search using pure mass spectra resolved by HELP with the aid of automated mass spectral deconvolution and identification system (AMDIS) software and temperature-programmed retention indices (PTRIs), while quantitative analysis was conducted using the overall volume integration (OVI) technique. A total of 43 out of 76 compounds were tentatively identified, accounting for 82.76% of the total flavor compounds. The flavor compounds were mainly esters, alkanes, alcohols, ketones, aldehydes, and fatty acids, with a composition of 22.24%, 22.16%, 17.75%, 9.06%, 5.72%, and 4.18%, respectively. Together, these results indicate that analyzing the rice bran flavor profile may be more reasonable than solely monitoring free fatty acids for understanding, evaluating and controlling the instability of rice bran.
Real-Time Application Domain Visionaries (2000)

The gulf separating the real-time research, product development, and application development communities appears to be the largest in the entire computing field. This gulf has an unfortunate tendency to obscure the research opportunities of most value to the real-time application domains. It is an unsurprising consequence of factors historically intrinsic to each of those communities.Almost all academic, and much industrial, research in the area of real-time computing - and especially distributed real-time computing - suffers from two handicaps. First is the necessity for unusually extensive application domain-specific knowledge and understanding compared with what is required in most other computer science and engineering research. Second is the directly contrary reality that few real-time researchers have the option of obtaining such knowledge and understanding, because they lack access to non-trivial, deployed, real-time application environments - particularly to distributed ones (e.g., in process control or discrete manufacturing plants, defense systems, telecommunication intelligent network architectures) - and to the developers and users of those environments.The real-time application domain practitioners (real-time computer product and application developers and users) contribute to this gulf as well. First, the historical focus on traditional small, static, centralized, sampled-data subsystems has often subjected real-time computers to severe constraints on hardware cost, size, weight, and power. And although software development and maintenance costs per line of source code are generally one or two orders of magnitude greater for real-time software than for non-real-time software, the smallest scale instances of these subsystems actually have negligible costs for software compared with hardware. These two factors tend to discourage many of the application developers and users from believing that they need or can afford technology advances from the software and real-time research communities. Second, hardware parsimony makes it necessary, and application simplicity makes it possible, for the application programmers to do the majority of the system's resource management - most of it a' priori, and as little as possible at run time.The increasing importance and deployment of larger scale, more complex, more distributed real-time computer systems makes this gulf an increasingly greater obstacle to their cost-effectiveness and even viability. The purpose of this session is to assist in reducing this gulf by bringing to ISORC2K's researcher audience some of the most prominent visionaries in some of real-time computing's most important application domains.
Surfactant Distribution in Waterborne Acrylic Films. 1. Bulk Investigation (2010)

The distribution of an anionic surfactant, sodium dodecyl sulfate (SDS), in waterborne acrylic films was investigated, focusing on the effects of particle composition and size, and pH of the latex. The observed surfactant distributions could be classified in two categories: homogeneous and heterogeneous, the latter showing SDS aggregates. The shape of the profiles was related to the stability of the latex during drying, at short interparticular distances. The stability of the latex was determined by the presence or not of fixed charges at the surface of the particles. The latices with particles carrying neutralized acrylic acid at high pH (COO(-)) led to homogeneous distributions, whereas the latices with acrylic acid at low pH (COOH) or without acrylic acid led to heterogeneous distributions. Our interpretation is that the stable latices present a narrow network of paths between particles at high polymer volume fraction, limiting the mobility of the surfactant, whereas in the less stable latices wider routes between flocs allow enough mobility for large aggregate formation. Thermal treatments of the dry films confirmed the strong confinement of the surfactant in the dense film structure obtained at high pH and the more open structure, allowing easier surfactant transport and oxygen penetration, observed at low pH. In order to account for the shapes of the profiles more quantitatively, a model was developed based on the diffusion of the surfactant and its transport by the drying front. It was found that the apparent diffusion coefficient of SDS micelles had to be lowered to a great extent (D = 10(-13)-10(-14) m(2)/s) during drying in order to explain aggregate formation. It should be even lower (D = 10(-15) m(2)/s) to interpret homogeneous surfactant profiles. These results are consistent with our hypothesis of the key importance of the surfactant mobility during drying.
DNA sensing using split-ring resonator alone at microwave regime (2010)

In this paper, the feasibility of utilization of a single element double split-ring resonator as a biosensing device has been demonstrated. The compact resonator has been excited by time-varying magnetic fields generated from the 50 Ω microstrip transmission line. In this work, DNA hybridization is recognized with shift in S21 resonant frequency. When thiol-linked single stranded-DNA is immobilized onto a gold (Au) surface and is then coupled with complementary-DNA, the frequency changes by Δfss-DNA=20 MHz and Δfhybridization=60 MHz, respectively. Thus, it is clear that the resonator can be utilized as a DNA sensing element in the microwave regime.
Scorpion Venom Heat–Resistant Synthesized Peptide Increases Stress Resistance and Extends the Lifespan of Caenorhabditis elegans via the Insulin/IGF-1-Like Signal Pathway (2022)

Improving healthy life expectancy by targeting aging-related pathological changes has been the spotlight of geroscience. Scorpions have been used in traditional medicine in Asia and Africa for a long time. We have isolated heat-resistant peptides from scorpion venom of Buthusmartensii Karsch (SVHRP) and found that SVHRP can attenuate microglia activation and protect <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) against β-amyloid toxicity. Based on the amino acid sequence of these peptides, scorpion venom heat-resistant synthesized peptide (SVHRSP) was prepared using polypeptide synthesis technology. In the present study, we used <i>C. elegans</i> as a model organism to assess the longevity-related effects and underlying molecular mechanisms of SVHRSP <i>in vivo</i>. The results showed that SVHRSP could prolong the lifespan of worms and significantly improve the age-related physiological functions of worms. SVHRSP increases the survival rate of larvae under oxidative and heat stress and decreases the level of reactive oxygen species and fat accumulation <i>in vivo</i>. Using gene-specific mutation of <i>C. elegans</i>, we found that SVHRSP-mediated prolongation of life depends on Daf-2, Daf-16, Skn-1, and Hsf-1 genes. These results indicate that the antiaging mechanism of SVHRSP in nematodes might be mediated by the insulin/insulin-like growth factor-1 signaling pathway. Meanwhile, SVHRSP could also up-regulate the expression of stress-inducing genes Hsp-16.2, Sod-3, Gei-7, and Ctl-1 associated with aging. In general, our study may have important implications for SVHRSP to promote healthy aging and provide strategies for research and development of drugs to treat age-related diseases.
Simultaneous scalability and security for data-intensive web applications (2006)

For Web applications in which the database component is the bottleneck, scalability can be provided by a third-party Database Scalability Service Provider (DSSP) that caches application data and supplies query answers on behalf of the application. Cost-effective DSSPs will need to cache data from many applications, inevitably raising concerns about security. However, if all data passing through a DSSP is encrypted to enhance security, then data updates trigger invalidation of large regions of cache. Consequently, achieving good scalability becomes virtually impossible. There is a tradeoff between security and scalability, which requires careful consideration.In this paper we study the security-scalability tradeoff, both formally and empirically. We begin by providing a method for statically identifying segments of the database that can be encrypted without impacting scalability. Experiments over a prototype DSSP system show the effectiveness of our static analysis method--for all three realistic bench-mark applications that we study, our method enables a significant fraction of the database to be encrypted without impacting scalability. Moreover, most of the data that can be encrypted without impacting scalability is of the type that application designers will want to encrypt, all other things being equal. Based on our static analysis method, we propose a new scalability-conscious security design methodology that features: (a) compulsory encryption of highly sensitive data like credit card information, and (b) encryption of data for which encryption does not impair scalability. As a result, the security-scalability tradeoff needs to be considered only over data for which encryption impacts scalability, thus greatly simplifying the task of managing the tradeoff.
Localization-enhanced biexciton binding in semiconductors (1999)

The influence of excitonic localization on the binding energy of biexcitons is investigated for quasi-three-dimensional and quasi-two-dimensional ${\mathrm{Al}}_{x}{\mathrm{Ga}}_{1\ensuremath{-}x}\mathrm{As}$ structures. An increase of the biexciton binding energy is observed for localization energies comparable to or larger than the free biexciton binding energy. A simple analytical model for localization in the weak confinement regime ascribes the increase to a quenching of the additional kinetic energy of the exciton-exciton motion in the biexciton.
Protocol-in-a-Day Workshop: A Lean Approach to Clinical Trial Development and Focus on Junior Faculty Development (2019)

Academic clinical trial development is complex and requires a variety of professional skill sets for successful implementation. Although most principal investigators who develop clinical trials are clinical research faculty, few are formally trained. The need for efficient development of clinical trialists is emphasized by the rapidly increasing number of trials, which rose from approximately 233,000 in 2017 to >290,000 in 20181 with a predicted global cost of $64 billion by 2020.2 Even at the largest cancer centers in the United States, facilitating the development of junior faculty to design and implement clinical trials can be challenging.