gebhart/patrepeval huggingface dataset:
Bail-out technique to detach a locked Viabahn endoprosthesis in branched thoracic endovascular aortic repair (2021)

A 69-year-old female patient presented with a 5.8 cm thoracoabdominal aortic aneurysm Crawford type II after partial arch replacement. She was treated by a branched thoracic endovascular aortic repair procedure using a branched arch endograft with one retrograde branch to the left subclavian artery. After deployment of a Viabahn as a bridging covered stent to the left subclavian artery, the deployment line did not detach and the delivery catheter could not be removed. With the use of a physician-modified sidehole catheter and balloon fixation, the pulling line could be released without displacement of the Viabahn endoprosthesis.
Pharmacogenetic biomarkers for predicting drug response (2014)

Drug response shows significant interpatient variability and evidence that genetics influences outcome of drug therapy has been known for more than five decades. However, the translation of this knowledge to clinical practice remains slow. Using examples from clinical practice six considerations about the implementation of pharmacogenetics (PGx) into routine care are discussed: the need for PGx biomarkers; the sources of genetic variability in drug response; the amount of variability explained by PGx; whether PGx test results are actionable; the level of evidence needed for implementation of PGx and the sources of information regarding interpretation of PGx data.
PEROXIDASE-CATALYZED POLYMERIZATION OF FLUORINE-CONTAINING PHENOLS (2000)

Peroxidase-catalyzed oxidative polymerization of fluorine-containing phenols has been performed in a mixture of a water-miscible organic solvent and buffer at room temperature under air. The monomers used were 2,6-difluorophenol, 3- and 4-fluorophenols. In the polymerization of 2,6-diflurophenol catalyzed by horseradish peroxidase (HRP), effects of an organic solvent, buffer pH, and their mixed ratio have been systematically investigated with respect to the polymer yield and molecular weight. The resulting polymer was soluble in common polar organic solvents and showed good water repellent property. From NMR and IR data, it was supposed that the polymer was of mainly 2,6-difluoro-1,4-oxyphenylene unit. Elemental analysis showed that the elimination of a small amount of the fluorine atom took place during the polymerization. HRP catalysis induced the polymerization of 3- and 4-fluorophenols, yielding a new class of fluorine-containing polyphenols.
Thalamic Deep Brain Stimulation (2018)

The use of deep brain stimulation (DBS) of the thalamus has been proven to be a safe and efficacious treatment for the management of many diseases. The most common indication for thalamic DBS remains essential tremor (ET), one of the most common movement disorders in the world. ET patients should be considered for surgical intervention when their tremor has demonstrated to be refractory to medication, a characteristic estimated to be present in roughly 50% of ET cases. Advantages of DBS over thalamotomy include its reversibility, the ability to adjust stimulation settings to optimize efficacy and minimize side effects, the ability to perform bilateral procedures safely, and an association with a lower risk of postoperative cognitive problems. The most common target of DBS for ET is the ventralis intermedius (VIM) of the thalamus, and the optimal electrode location corresponds to the anterior margin of the VIM. Other indications for thalamic DBS include non-ET tremor, obsessive-compulsive disorder, neuropathic pain, traumatic brain injury, Tourette's syndrome, and drug-resistant epilepsy among others.
The α-glucosidase inhibitor miglitol suppresses postprandial hyperglycaemia and interleukin-1β and tumour necrosis factor-α gene expression in rat peripheral leucocytes induced by intermittent sucrose loading (2009)

Postprandial hyperglycaemia is thought to increase inflammation in leucocytes. In the present study, we examined whether sucrose loading in rats with moderate postprandial hyperglycaemia induces the expression of cytokines in peripheral leucocytes and whether these inductions are suppressed by inhibiting postprandial hyperglycaemia with the alpha-glucosidase inhibitor miglitol. One group of streptozotocin-treated rats and age-matched saline-treated rats were orally administered sucrose only, and another group of streptozotocin-treated rats was administered sucrose with miglitol, at a single daily dose for 4 d, under 4 h fasting conditions. Blood glucose levels at 0, 0.25, 0.5, 1, 2 and 3 h and cytokine mRNA in peripheral leucocytes at 0 and 3 h after sucrose loading on days 1 and 4 from the start of sucrose loading were determined. Streptozotocin-treated rats showed moderate postprandial hyperglycaemia (>2000 mg/l) at 0.25-1 h after sucrose loading on days 1 and 4. Postprandial hyperglycaemia was not observed in the miglitol-treated rats loaded with sucrose. Gene expression levels of IL-1beta and TNF-alpha were higher in the streptozotocin-treated rats at fasting on day 1 than in saline-treated rats. Fasting IL-1beta and TNF-alpha gene expression on day 1 were not only increased at 3 h on the same day of sucrose loading, but was also increased at the fasting period on day 4. These inductions on day 4 by intermittent sucrose administration were inhibited by miglitol. The present results suggest that miglitol decreases postprandial hyperglycaemia and intermittent sucrose-induced expression of the IL-1beta and TNF-alpha genes in rat peripheral leucocytes.
Mass spectrometry PittCon ’95 (1995)

ADVERTISEMENT RETURN TO ISSUEPREVConference ReviewNEXTMass spectrometry PittCon '95O. David SparkmanO. David SparkmanMass Spectrometry Consultant, 4045 East Ridge Drive, 94509, Antioch, CAMore by O. David SparkmanCite this: J Am Soc Mass Spectrom 1995, 6, 7, 613–615Publication Date (Print):July 1, 1995Publication History Published online1 July 1995Published inissue 1 July 1995https://pubs.acs.org/doi/10.1016/1044-0305(95)00501-4https://doi.org/10.1016/1044-0305(95)00501-4review-articleACS PublicationsRequest reuse permissionsArticle Views4Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Electrical measurements on electron irradiated n-and p-type GaAs (1972)

Abstract Hall effect and resistivity measurements have been made on undoped n-type and Cd-doped p-type GaAs crystals irradiated with electrons at 287°K. For 1 MeV irradiations, the dose dependence of carrier removal and mobility in n-type suggests that a defect energy level at E c-0.1±0.015 eV was introduced by irradiation and was the upper level of a doubly charged acceptor. A donor level was also found in n-type at approximately E c − 0.20 eV, and deeper acceptor levels were also introduced. In p-type a similar study located a radiation introduced level at E v +0.1 ± 0.015 eV, which could be a singly or doubly ionized donor. Measurements of the carrier removal rate in p-type as a function of beam energy were in good agreement with those previously reported for n-type, thus confirming the displacement energy of 17–18 eV. It is suggested that the majority of displacement events gave rise to electrically active defects.
Suppressive effect of Siraitia grosvenorii extract on dicyclanil-promoted hepatocellular proliferative lesions in male mice (2009)

Dicyclanil (DC) generates reactive oxygen species (ROS) due to Cyp1a1 induction, and DNA damage caused by oxidative stress is probably involved in hepatocarcinogenesis in mice. To clarify the modifying effect of the Siraitia grosvenorii extract (SGE), which has antioxidative properties, we employed a 2-stage liver carcinogenesis model in partially hepatectomized male ICR mice. Mice maintained on diet containing DC at a concentration of 1,500 ppm for 9 weeks after a single intraperitoneal injection of diethylnitrosamine (DEN) at a dose of 30 mg/kg and they were given water containing 2,500 ppm of SGE for 11 weeks including 2 weeks as pre-administration on DC. SGE inhibited the induction of gamma-glutamyltranspeptidase-positive hepatocytes, lipid peroxidation, and gene expression of Cyp1a1, all of which were caused by DC. To examine whether SGE indirectly inhibits Cyp1a1 expression induced by inhibition of aryl hydrocarbon receptor (Ahr)-mediated signal transduction caused by DC, mice with high (C57BL/6J mice) and low affinities (DBA/2J mice) to Ahr were given DC-containing diet and/or SGE-containing tap water for 2 weeks. Cyp1a1 gene expression was significantly lower in C57BL/6J mice administered DC + SGE than in C57BL/6J mice administered DC alone; there was no difference in the Cyp1a1 expression between DBA/2J mice administered DC + SGE and DC alone. These results suggest that SGE suppresses the induction of Cyp1a1, leading to inhibition of ROS generation and consequently inhibited hepatocarcinogenesis, probably due to suppression of Ahr activity.
SARS-CoV-2 infects and damages the mature and immature olfactory sensory neurons of hamsters. (2020)

BACKGROUND: Coronavirus Disease 2019 (COVID-19) is primarily an acute respiratory tract infection. Distinctively, a substantial proportion of COVID-19 patients develop olfactory dysfunction of uncertain underlying mechanism which can be severe and prolonged. The roles of inflammatory obstruction of the olfactory clefts leading to conductive impairment, inflammatory cytokines affecting olfactory neuronal function, destruction of olfactory neurons or their supporting cells, and direct invasion of olfactory bulbs, in causing olfactory dysfunction are uncertain. METHODS: In this study, we investigated the location for the pathogenesis of SARS-CoV-2 from the olfactory epithelium (OE) of the nasopharynx to the olfactory bulb of golden Syrian hamsters. RESULTS: After intranasal inoculation with SARS-CoV-2, inflammatory cell infiltration and proinflammatory cytokine/chemokine responses were detected in the nasal turbinate tissues which peaked between 2 to 4 days post-infection with the highest viral load detected at day 2 post-infection. Besides the nasopharyngeal pseudo-columnar ciliated respiratory epithelial cells, SARS-CoV-2 viral antigens were also detected in the more superficial mature olfactory sensory neurons labeled by olfactory marker protein (OMP), the less mature olfactory neurons labelled by Tuj1 at more basal position, and the sustentacular cells which provide metabolic and physical support for the olfactory neurons, resulting in apoptosis and severe destruction of the OE. During the whole course of infection, SARS-CoV-2 viral antigens were not detected in the olfactory bulb. CONCLUSIONS: Besides acute inflammation at OE, infection of mature and immature olfactory neurons, and the supporting sustentacular cells by SARS-CoV-2 may contribute to the unique olfactory dysfunction of COVID-19 which is not reported with SARS-CoV.
X-ray Image Reconstruction by Radon Transform Simulation with Fan-Beam Allocation (2007)

A Radon transform algorithm, which incorporates correlated X-ray images into the processing of back- projection with fan-beam geometry reconstruction with the aim of improving image quality, was developed. We evaluate and compare these reconstruction images with the original image. The results show that the proposed method produces reconstructed images with quiet high peak-signal-to-noise ratio.
Impact of Non-interruptive Medication Laboratory Monitoring Alerts in Ambulatory Care (2008)

We found that non-interruptive medication laboratory monitoring alerts were not effective in improving receipt of recommended baseline laboratory test monitoring for medications. Further work is necessary to optimize compliance with non-critical recommendations.
Material Database Syndication with RSS (2007)

Every material database on the Internet has a different data schema. There are some trial attempts to define unified schema for material databases, but since the structure of scientific data is very complicated and changes dynamically, defining a complete data schema is an impossible task. There are two major approaches for material data standards: one is MatDB, an attempt to define precise and detailed metadata, and the other is MatML, which only defines a framework. However, there is a third way: loose syndication, such as blogs with RSS. RSS, RDF Site Summary, or Really Simple Syndication, was developed to summarize document pages, but it can be extended to describe metadata of factual databases. In this presentation, an RSS extension for material database summaries is discussed.
Neural Correlates of Levels of Emotional Awareness: Evidence of an Interaction between Emotion and Attention in the Anterior Cingulate Cortex (1998)

Recent functional imaging studies have begun to identify the neural correlates of emotion in healthy volunteers. However, studies to date have not differentially addressed the brain areas associated with the perception, experience, or expression of emotion during emotional arousal. To explore the neural correlates of emotional experience, we used positron emission tomography (PET) and 15-water to measure cerebral blood flow (CBF) in 12 healthy women during film- and recall-induced emotion and correlated CBF changes attributable to emotion with subjects' scores on the Levels of Emotional Awareness Scale (LEAS), a measure of individual differences in the capacity to experience emotion in a differentiated and complex way. A conjunction analysis revealed that the correlations between LEAS and CBF during film- and recall-induced emotion overlapped significantly (z = 3.74, p < 0. 001) in Brodmann's area 24 of the anterior cingulate cortex (ACC). This finding suggests that individual differences in the ability to accurately detect emotional signals interoceptively or exteroceptively may at least in part be a function of the degree to which the ACC participates in the experiential processing and response to emotion cues. To the extent that this finding is consistent with the functions of the ACC involving attention and response selection, it suggests that this neural correlate of conscious emotional experience is not exclusive to emotion.
A new method for measuring the dynamic surface tension of complex-mixture liquid drops (1994)

A simple and accurate technique has been developed for measuring dynamic surface tension. The new technique is based on growing a drop at the end of a fine capillary into another immiscible fluid and can follow the changes in tension at a freshly formed interface during its entire period of evolution. When the relative importance of the surface tension force is large compared to gravitational and viscous forces, shapes of growing drops are sections of spheres and the difference in pressure between the interior and the exterior of the drop {triangle}p is related to the surface tension {sigma} and the radius of curvature R by the static Young-Laplace formula {triangle}p = 2{sigma}/R. In contrast to related work, the new technique can determine the surface tension of an interface with a surface age of a few to tens of milliseconds by measuring transient drop shapes and pressures in 1/6 to 1 millisecond. The capabilities of the new method are demonstrated by performing tension measurements on liquid systems that do not exhibit dynamic surface tension as well as ones that exhibit significant dynamic tension effects. Tension measurements made with surfactant-laden solutions show that variation of surface tension is nonmonotonic in time. In such systems, the dynamic behavior of surface tension is shown to depend upon both the rate of interfacial dilatation and that of surfactant transport. A maximum in the surface tension is attained when the lowering of the surfactant concentration on the drop interface due to its dilatation is balanced by the addition of fresh surfactant to the interface by convection and diffusion.
On the Adsorption Behavior of Biotin-Binding Proteins on Gold and Silica (2009)

Streptavidin (SAv), avidin (Av), and neutravidin (NAv) have become widely used molecular tools in biotechnology thanks to their remarkable affinity for biotin. Their tetravalency renders these molecules particularly interesting for the functionalization of solid-liquid interfaces. Using the quartz crystal microbalance with dissipation monitoring, we systematically investigate the deposition of biotin-binding proteins to two surfaces that are popular in biotechnology: gold and silica. We find that simple physisorption of biotin-binding proteins is a viable method to confer biotin-binding functionality to gold surfaces. Both SAv and Av form dense, stable protein monolayers that retain biotin-binding activity and are largely inert to the unspecific binding of bovine serum albumin. Furthermore, we report that SAv resists adsorption to silica over a wide range of pH and ionic strength. The contrast in the binding behavior of SAv on silica and on gold suggests a simple strategy for the selective biofunctionalization of nano- or microstructured surfaces.
Large-scale modelling of sparse kinase activitydata (2023)

Protein kinases are a protein family that play an important role in several complex diseases such as cancer, cardiovascular and immunological diseases. Kinases have conserved binding sites, which when targeted can lead to similar activities of inhibitors against different kinases. This can be exploited to create multi-target drugs. On the other hand, selectivity (lack of similar activities) is desirable in order to avoid toxicity issues. There is a vast amount of kinase activity data in the public domain, which can be used in many different ways. Multi-task machine learning models are expected to excel for these kinds of datasets because they can learn from implicit correlations between tasks (in this case activities against a variety of kinases). However, multi-task modelling of sparse data poses two major challenges: (i) creating a balanced train-test split without data leakage and (ii) handling missing data. In this work, we construct a kinase benchmark set composed of two balanced splits without data leakage, using random and dissimilarity-driven cluster-based mechanisms, respectively. This data set can be used for benchmarking and developing kinase activity prediction models. Overall, the performance on the dissimilarity-driven cluster-based split is lower than on random splits based sets for all models, indicating poor generalizability of models. Nevertheless, we show that multi-task deep learning models, on this very sparse dataset, outperform single-task deep learning and tree-based models. Finally, we demonstrate that data imputation does not improve the performance of (multitask) models on this benchmark set.
Phlegm-based Treatment of Cancer Pain (2010)

Cancer pain is one of dominant symptoms of patients with advanced cancer,and belongs to the concept of pain syndrome in Traditional Chinese Medicine(TCM).Phlegm is one important pathogenesis which inducing cancer pain,and dispersing phlegm is a considerable therapy of treating cancer pain.
Distinct amyloid-dependent patterns of nigra dopamine depletion in Lewy body diseases (2023)

This study demonstrates different amyloid-dependent or amyloid-independent<sup>18</sup>F-FP-CIT PET patterns in patients with LBD, suggesting distinctive interactions between α-synuclein and amyloid pathology based on the type of LBD.
Suspended graphene beams with tunable gap for squeeze-film pressure sensing (2017)

We present suspended graphene pressure sensors fabricated using an innovative surface micro-machining process. The great advantage of this process is that the molybdenum (Mo) catalyst layer for multi-layer graphene chemical vapor deposition (CVD) is also used as a sacrificial layer to suspend the graphene. This method allows for accurate control of the gap size under the beam by simply varying the catalyst thickness. Furthermore, the need for transfer of the graphene layer is eliminated. Using this method, wafer-scale graphene squeeze-film pressure sensors are fabricated and characterized.
ChemInform Abstract: Mucocin: A New Annonaceous Acetogenin Bearing a Tetrahydropyran Ring. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synthesis and functionalities of poly(N-vinylalkylamide). VI. A novel thermosensitive hydrogel crosslinked poly(N-vinylisobutyramide) (1997)

A novel thermosensitive poly(N-vinylisobutyramide)(polyNVIBA) hydrogel was prepared by the copolymerization of N-vinylisobutyramide (NVIBA) with butylene-bis-NVA(B-BNVA) as a crosslinker in a high yield. The swelling transition behavior was examined in comparison with poly(N-isopropylacrylamide)(polyNIPAAm) hydrogel. The resulting polyNVIBA hydrogel clearly showed a swelling transion in water at ca. 41°C. To control the transition temperature (Tt) of the gel, crosslinked copolymers of NVIBA and N-vinylacetamide (NVA) were prepared and compared with copolymers of N-isopropylacrylamide(NIPAAm) and NVA. The incorporation of NVA led to a higher swelling transition temperature. Tt of poly(NVIBA-co-NVA) gels was almost the same as those in water-soluble poly(NVIBA-co-NVA). The responses for a swelling transition of polyNVIBA and poly(NVIBA-co-NVA) gels were sharp in comparison to polyNIPAAm gels. PolyNVIBA and poly(NVIBA-co-NVA) gels desorbed 98% of water above Tt. The characteristic and the mechanism of the phase transition on the hydrogels were discussed. © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35: 3377–3384, 1997