gebhart/patrepeval huggingface dataset:
Learning Binary and Sparse Permutation-Invariant Representations for Fast and Memory Efficient Whole Slide Image Search (2022)

Learning suitable Whole slide images (WSIs) representations for efficient retrieval systems is a non-trivial task. The WSI embeddings obtained from current methods are in Euclidean space not ideal for efficient WSI retrieval. Furthermore, most of the current methods require high GPU memory due to the simultaneous processing of multiple sets of patches. To address these challenges, we propose a novel framework for learning binary and sparse WSI representations utilizing a deep generative modelling and the Fisher Vector. We introduce new loss functions for learning sparse and binary permutation-invariant WSI representations that employ instance-based training achieving better memory efficiency. The learned WSI representations are validated on The Cancer Genomic Atlas (TCGA) and Liver-Kidney-Stomach (LKS) datasets. The proposed method outperforms Yottixel (a recent search engine for histopathology images) both in terms of retrieval accuracy and speed. Further, we achieve competitive performance against SOTA on the public benchmark LKS dataset for WSI classification.
Histamine selectively interrupts VE-cadherin adhesion independently of capacitive calcium entry (2004)

Histamine is an important agent of innate immunity, transiently increasing the flux of immune-competent molecules from the vascular space to the tissues and then allowing rapid restoration of the integrity of the endothelial barrier. In previous work we found that histamine alters the endothelial barrier by disrupting cell-cell adhesion and identified VE-cadherin as an essential participant in this process. The previous work did not determine whether histamine directly interrupted VE-cadherin adhesion, whether the effects of histamine were selective for cadherin adhesion, or whether capacitive calcium flux across the cell membrane was necessary for the effects of histamine on cell-cell adhesion. In the current work we found that histamine directly interrupts adhesion of L cells expressing the type 1 histamine (H1) receptor and VE-cadherin to a VE-cadherin-Fc fusion protein. In contrast, integrin-mediated adhesion to fibronectin of the same L cells expressing the H1 receptor was not affected by histamine, demonstrating that the effects of histamine are selective for cadherin adhesion. Some of the effects of many edemagenic agonists on endothelium are dependent on the capacitive flux of calcium across the endothelial cell membrane. Blocking capacitive calcium flux with LaCl3 did not prevent histamine from interrupting VE-cadherin adhesion of transfected L cells, nor did it prevent histamine from interrupting cell-cell adhesion of human umbilical vein endothelial cells. These data support the contentions that histamine directly and selectively interrupts cadherin adhesion and this effect on cadherin adhesion is independent of capacitive calcium flux.
Low doses of zinc gluconate for inflammatory acne. (1989)

The effect of zinc on acne is unclear. In this study, only patients with an inflammatory acne were included in a double-blind trial using low doses of zinc gluconate (200 mg/day, corresponding to 30 mg zinc metal). We obtained a significantly different result between zinc and placebo groups in the inflammatory score (p less than 0.02). This efficiency could be explained by the action of zinc on inflammatory cells, especially granulocytes.
A structured assessment of emergency and acute care providers in Afghanistan during the current conflict (2015)

There is a significant need to provide emergency care services in Afghanistan, specifically prehospital care. High variability exists among facility-type in various components of emergency services provision.
The Multimodal Sentiment Analysis in Car Reviews (MuSe-CaR) Dataset: Collection, Insights and Improvements (2021)

Truly real-life data presents a strong, but exciting challenge for sentiment and emotion research. The high variety of possible ‘in-the-wild’ properties makes large datasets such as these indispensable with respect to building robust machine learning models. A sufficient quantity of data covering a deep variety in the challenges of each modality to force the exploratory analysis of the interplay of all modalities has not yet been made available in this context. In this contribution, we present MuSe-CaR, a first of its kind multimodal dataset. The data is publicly available as it recently served as the testing bed for the 1st Multimodal Sentiment Analysis Challenge, and focused on the tasks of emotion, emotion-target engagement, and trustworthiness recognition by means of comprehensively integrating the audio-visual and language modalities. Furthermore, we give a thorough overview of the dataset in terms of collection and annotation, including annotation tiers not used in this year's MuSe 2020. In addition, for one of the sub-challenges – predicting the level of trustworthiness – no participant outperformed the baseline model, and so we propose a simple, but highly efficient Multi-Head-Attention network that exceeds using multimodal fusion the baseline by around 0.2 CCC (almost 50 percent improvement).
Generation of intense excimer radiation from high-pressure hollow cathode discharges (1998)

By reducing the diameter of the cathode opening in a hollow cathode discharge geometry to values on the order of 100 μm, we were able to operate these discharges in noble gases in a direct current mode up to atmospheric pressure. High-pressure discharges in xenon were found to be strong sources of excimer radiation. Highest intensities at a wavelength of 172 nm were obtained at a pressure of 400 Torr. At this pressure, the vacuum ultraviolet (VUV) radiant power of a single discharge operating at a forward voltage of 220 V and currents exceeding 2 mA reaches values between 6% and 9% of the input electrical power. The possibility to form arrays of these discharges allows the generation of flat panel VUV lamps with radiant emittances exceeding 50 W/cm2.
First Complete Genome Sequence of a French Bovine coronavirus Strain (2017)

We sequenced the first <i>Bovine coronavirus</i> (BCoV) complete genome sequence from France. This BCoV was directly sequenced from a fecal sample collected from a calf in Normandy in 2014.
Hemarthrosis associated with sodium warfarin therapy (1976)

Three patients with hemarthrosis of the knee joint complicating sodium warfarin oral anticoagulation therapy are described. In all 3 the prothrombin time was at least 2.4 times the control value at the time of hemarthrosis. After initial bleeding was controlled, 2 patients had recurrences at times when their prothrombin times were again more than 2.5 times greater than those of the normal control subject. Joint symptoms persisted in all patients until the warfarin dose was substantially decreased or discontinued. Underlying joint disease was present in 1 individual and may have predisposed him to the occurrence of hemarthrosis. No long-term joint damage was recognized as resulting from the hemarthrosis at followup 1 to 2 years later. The authors conclude that hemathrosis associated with oral anticoagulant therapy occurs when the prothrombin time is excessively prolonged any may remain symptomatic until anticoagulation is reduced or discontinued. Management includes careful diagnostic aspiration, despite the prolonged prothrombin time, and discontinuation of anticoagulation.
Crack Growth Model for the Probabilistic Assessment of Inspection Strategies for Steam Generator Tubes (2009)

Assessment of the conditional probabilities of tube failures, leak rates, and ultimately risk of exceeding licensing dose limits as an approach used to steam generator tube fitness-for-service assessment has begun to be used increasingly in recent years throughout the nuclear power industry. One of the important topics in the assessment is the crack growth model that predicts the growth of crack size with time. The plot of the log of change in crack length per cycle, against the log of stress intensity factor range shows three distinct regions where in Regions I and III the change in crack length per cycle increases faster with stress intensity factor. On the other hand Region II shows linear variation. While effective for predicting Region II of fatigue crack growth, “Paris law” is often not properly used in making life predictions because a majority of the fatigue life of a specimen occurs in Region I. Physical models for Region I growth have not yet been successful. Recently substantial effort is made in modeling crack growth model with experimental data for Regions I and II. The present work reviews recent work in predicting the fatigue crack growth rate in Region I and II. The characteristics of such models are examined and their limitations are discussed in context with steam generator tube crack growth. Recommendations are made on crack growth models for region I and II.
An 11-bit 8.6GHz direct digital synthesizer MMIC with 10-bit segmented nonlinear DAC (2008)

This paper presents a low power, high speed and high resolution SiGe DDS MMIC with 11-bit phase and 10-bit amplitude resolutions. Using more than twenty thousand transistors, including an 11-bit pipeline accumulator, a 6-bit coarse DAC and seven 3-bit fine DACs, the core area of the DDS is 3 times 2.5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The maximum clock frequency was measured at 8.6 GHz with 4.2958 GHz output. The DDS consumes a power of 4.8 W under a 3.3 V power supply. It achieves the best reported phase and amplitude resolutions and the best power efficiency figure of merit (FOM) 182 GHz ldr 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ENOB</sup> /W. The measured SFDR is approximately 40 dBc with 4.2958 GHz Nyquist output and 48 dBc with 4.2 MHz output at the maximum clock frequency of 8.6 GHz. The chip was measured using LCC-52 packages.
Polyoxyethylene ethers of some polyol glycosides and their fatty esters (1963)

Abstract Starch heated with a polyol, such as ethylene glycol, propylene glycol, or glycerol, in the presence of an acid catalyst undergoes transglycosidation and forms a mixture of polyol glycosides. This mixture is sufficiently heat‐stable to permit polyetherification with ethylene oxide. The preparation and properties of a number of glycoside polyoxyethylene ethers are described. Nonionic emulsifying agents were prepared by reacting glycoside polyethers with either saturated or unsaturated long‐chain fatty acids and linseed oil. In general, the esterified glycoside polyethers exhibited good emulsifying action, and the unsaturated esters of the polyethers possessed film‐forming properties.
Bandwidth Enhanced Operation of Single Mode Semiconductor Laser by Intensity Modulated Signal Light Injection (2012)

3dB bandwidth enhancement of single mode semiconductor lasers is confirmed numerically and experimentally when they are operated by intensity modulated signal light injection. 3dB bandwidth is enlarged to 2.5 times of resonant frequency. The numerical analysis of rate equations predicts that the bandwidth enhancement is accomplished by the modal gain control of semiconductor lasers with injected intensity modulated signal light through non-linear gain coefficient term.
Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5). (1996)

We have molecularly cloned a cDNA encoding a protein uniquely expressed and hyperphosphorylated at tyrosine residues in a Ki-1 lymphoma cell that contained chromosomal translocation t(2;5). The encoded protein p80 was shown to be generated by fusion of a protein-tyrosine kinase and a nucleolar protein B23/nucleophosmin (NPM). The coding sequence of this cDNA turned out to be virtually identical to that of the fusion cDNA for NPM-anaplastic lymphoma kinase (ALK) previously cloned from the transcript of the gene at the breakpoint of the same translocation. Overexpression of p80 in NIH 3T3 cells induced neoplastic transformation, suggesting that the p80 kinase is aberrantly activated. The normal form of p80 was predicted to be a receptor-type tyrosine kinase on the basis of its sequence similarity to the insulin receptor family of kinases. However, an immunofluorescence study using COS cells revealed that p80 was localized to the cytoplasm. Thus, subcellular translocation and activation of the tyrosine kinase presumably by its structural alteration would cause the malignant transformation. We also showed that a mutant p80 lacking the NPM portion was unable to transform NIH 3T3 cells. Thus, the NPM sequence is essential for the transforming activity, suggesting that the chromosomal translocation is responsible for the oncogenesis. Finally, Shc and insulin receptor substrate 1 (IRS-1) were tyrosine-phosphorylated and bound to p80 in p80-transformed cells. However, mutants of p80 that were defective for binding to and phosphorylation of Shc and insulin receptor substrate 1 could transform NIH 3T3 cells. Association of these mutants with GRB2 was still observed, suggesting that interaction of p80 with GRB2 but not with Shc or IRS-1 was relevant for cell transformation.
27.4 Inverse Designed, Densely Integrated Classical and Quantum Photonics (2023)

Photonics - manipulation of flow of light on a chip - has many exciting applications, including new computing and communication platforms that are faster, more compact and more energy efficient, and a variety of sensors for medicine, autonomous vehicles, and the environment. Despite a great progress in photonics over the past few decades, photonic systems are nowhere near the level of integration and complexity comparable to those of electronic circuits, which prevents use of photonics in many applications. This lag in integration scale is in large part a result of how photonics is traditionally designed: by combining building blocks from a limited library of known designs, and by manual tuning of few parameters. Unfortunately, the resulting photonic circuits are often bulky, inefficient, and very sensitive to errors in manufacturing and the environment.
Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope (2015)

Many in the HIV/AIDS vaccine field believe that the ability to elicit broadly neutralizing antibodies capable of blocking genetically diverse HIV-1 variants is a critical component of a protective vaccine. Various SIV-based nonhuman primate vaccine studies have investigated ways to improve antibody-mediated protection against a heterologous SIV challenge, including administering adjuvants that might stimulate a greater neutralization breadth. Using a novel SIV neutralization panel and samples from four rhesus macaque vaccine trials designed for cross comparison, we show that different regimens expressing the same SIV envelope immunogen consistently elicit antibodies that neutralize only the very sensitive tier 1a SIV variants. The results argue that the neutralizing antibody profile elicited by a vaccine is primarily determined by the envelope immunogen and is not substantially broadened by including adjuvants, resulting in the conclusion that the envelope immunogen itself should be the primary consideration in efforts to elicit antibodies with greater neutralization breadth.
<title>Three-dimensional ultrasonic imaging: an aging aircraft nondestructive inspection tool</title> (1993)

Ultrasonic nondestructive evaluation is a valuable technique for finding defects in aircraft structures. It can detect unbonds, corrosion damage and cracks in various aircraft components. Ultrasonic nondestructive evaluation techniques interrogate materials with high frequency acoustic energy. A piezoelectric transducer generates acoustic energy and converts returned acoustic energy into electrical signals which can be processed to identify the reflector. The acoustic energy propagates through the component and is reflected by abrupt changes in modulus and/or density that can be caused by a defect. Ultrasonic nondestructive evaluation typically provides a two dimensional image of internal defects. These images are either a planar view (C-scan) or a cross-sectional view (B-scan) of the component. The planar view is generated by raster scanning an ultrasonic transducer over the area of interest and capturing the peak amplitude of internal reflections. Depth information is generally ignored. The crass-sectional view is generated by scanning the transducer along a line and capturing the amplitude and time of flight for each internal reflection. The amplitude and time of flight information is converted into an image of the cross section of the component. By fusing the C-scan information with the B-scan information a three dimension image of the internal structure of the component can be produced. The three dimensional image can be manipulated by rotating and slicing to produce the optimal view of the internal structure. Visualizing defects in three dimensions aids the interpretation of the severity of defects and helps confirm the need to repair or replace components.
Adsorption and dynamics of linear and mono-branched hexane isomers in MIL-140 metal–organic frameworks (2023)

Recent breakthrough experiments revealed the iso-reticular Zr-MOFs, MIL-140B and MIL-140C, as promising sorbents for the separation of C6 isomers. Interestingly while the ultra-small pore MIL-140B exhibited hexane isomer sorption hierarchy according to the normal boiling point order (<i>n</i>-C6 > 3MP (3-methyl pentane)), an uncommon shift in the elution order was observed in the larger pore MIL-140C. It was only speculated that the flexibility of the MOFs might be the origin of this intriguing behavior. Herein, flexible force field hybrid osmotic Monte Carlo combined with molecular dynamics simulations were carried out to unravel the microscopic mechanism of the adsorption and dynamics of both C6 isomers in MIL140B and MIL140C. Thermodynamically preferred adsorption of <i>n</i>-C6 over 3MP was predicted for MIL-140B and to a slightly less extent for MIL-140C. Interestingly while the mobility of <i>n</i>-C6 was found to remain higher than that of 3MP in the whole range of loading for MIL-140B, 3MP becomes more mobile than <i>n</i>-C6 at saturation in MIL-140C. This suggests that this kinetics order is most probably the origin of the inversion of the elution order observed experimentally for MIL-140C. The translational and rotational dynamics of the two guests in MIL-140B and MIL-140C was further understood in-depth.
Prospects for Biden Administration’s North Korea Policy Amid the U.S.-China Conflict (2021)

North Korea s nuclear and intercontinental ballistic missile program has captured theinternational community s attention beyond the Korean peninsula and became an intensifiedthreat, eroding international security and order for several decades. To deliver a completeresolution to the threat from North Korea, countries with interest in the Korean peninsula,such as the U.S., South Korea, and China, have implemented various behavioral approacheswith North Korea. However, their efforts were unable to prevent North Korea frombecoming a de facto nuclear power state. The Biden administration is pursuing practicaldiplomacy based on calibrated approaches to neutralize threats from North Korea. It expectsto consolidate its relations with traditional allies and partners, such as South Korea and theUnited Nations, for a practical result while potentially seeking a cooperative opportunitywith China. However, the current conflict between the U.S. and China is a negative factor tothe newly proposed North Korea policy by the Biden Administration. By analyzing Chinavia the power transition theory, China can be categorized as a potential challenger to thecurrent order. As the conflict intensifies, China actively seeks to secure supportive states toresist pressure from the U.S. and challenge the existing order. Meanwhile, the U.S. is alsotrying to strengthen cooperation with allies and partners to hinder China s attempt to powerparity which undoubtedly turned the two countries competition into a high-level, two-blocpower struggle.
Efficacy and Safety of a Novel Hemostatic Peptide Solution During Endoscopic Submucosal Dissection: A Multicenter Randomized Controlled Trial (2022)

TDM-621 is a useful, easily operable hemostatic peptide for treatment of blood oozing during gastric and rectal ESD, with no serious safety concerns.
A modular power electronics protoboard for didactic applications (2009)

Over ten years ago, the first laboratory course on power electronics was introduced in the Federal University of Rio de Janeiro (UFRJ). The course was conceived in conjunction with the development of a small, but consistent set of modules, which have been designed with the aim of making it easier to implement many different converter functions. After a decade of successful use, this conception has been proving so far to be very effective and versatile, that it motivated the effort for updating and improving the initial testbed. Undergraduate and graduated students have developed a variety of experiments using these modules. The whole material has evolved to a tool for interdisciplinary work on many subjects, such as: power electronics, electrical motor drives and digital control. An overview of ways to use this teaching tool is presented in this paper, along with a discussion about perspectives for the next years.
Catalytic Hydroconversion of 5‐HMF to Value‐Added Chemicals: Insights into the Role of Catalyst Properties and Feedstock Purity (2022)

5-hydroxymethylfurfural (HMF) is an important bio-derived platform molecule that is generally obtained from hexoses via acid-catalyzed dehydration. It can be effectively transformed into a variety of value-added derivatives, thus being an ideal candidate for fossil replacement. Both HMF oxidation and hydrogenation processes enable the synthesis of numerous chemicals, monomers for polymerization, and biofuel precursors. This Review summarizes the most recent advances in heterogeneous catalytic hydroconversion of HMF into valuable chemicals with strong focus on 2,5-bishydroxymethyl furan (BHMF), 2,5-bishydroxymethyltetrahydrofuran (BHMTHF), and 2,5-dimethyltetrahydrofuran (DMTHF). In addition, multifunctional catalytic systems that enable a tunable production of various HMF derived intermediates are discussed. Within this chemistry, the surprising impact of HMF purity on the catalytic performance, such as selectivity and activity, during its upgrading is highlighted. Lastly, the remaining challenges in the field of HMF hydroconversion to the mentioned chemicals are summarized and discussed, taking into account the knowledge gain of catalyst properties and feedstock purity.
Abstract 18064: Lipid Reduction Measurements in a Veteran Population - Implications for Genetic Modeling in the Million Veteran Program (2016)

Introduction: The 2013 ACC/AHA guidelines on the Treatment of Blood Cholesterol to Reduce Cardiovascular Risk presented a new statin algorithm to guide the selection of a statin agent and dosage ba...
Remarks on Facial Paralysis in Recent Otitis Media; and on the Treatment of Acute Otitis when the Hearing Power is threatened (1895)

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