gebhart/patrepeval huggingface dataset:
An Adaptive SAR ADC for DC to Nyquist Rate Signals (2018)

This paper proposes an adaptive algorithm for a predicting SAR ADC which can self-adjust the precision of its prediction. A precise and yet correct prediction reduces bit trials needed in a SAR conversion, leading to great power savings. The presented algorithm uses a 2-byte prediction-success-rate-register and a1 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> order digital negative feedback loop to control the prediction depth. Additionally, an offset-move-up technique is proposed to boost the prediction success rate when the previous sample is near the boundary of the predicted subrange. The boundary-crossing problem reduces energy-efficiency in other predictive SAR algorithms such as LSB-first. The proposed scheme makes aggressive predictions for low-activity biomedical signals, makes conservative predictions or no predictions for high-activity-high-amplitude signals and it automatically and smoothly transitions between the two extremes.
Quantitative Assessment of Coronary Atherosclerotic Plaque Profile by Morphometric Analysis of Angiographic Images (1996)

Coronary plaque morphology (simple or complex) has a recognized clinical, pathophysiologic, and prognostic importance, but its routine use is hampered by the subjective and qualitative nature of the assessment. The aim of this study was to assess the feasibility and accuracy of mathematical, objective, operator-independent assessment of plaque morphology, by means of algorithms based on vector and fractal analysis, previously developed for describing continuous curves. Twenty coronary angiograms were analyzed: 10 with "simple-type" stenosis (defined according to Ambrose type I pattern, Group I) and 10 with "complex-type" stenosis (Ambrose type II pattern, Group II). Five morphometric parameters effectively separated simple and complex-type stenosis: peaks/cm (Group I = 0.24 +/- 0.31 vs Group II = 2.46 +/- 1.83, P < .01); summed maximum error/cm (I = 0.94 +/- 1.19 vs II = 4.53 +/- 0.56, P < .01); integrated error/cm (I = 0.22 +/- 0.27 vs II = 2.25 +/- 1.68, P < .01); number of features/cm (I = 0.02 +/- 0.05 vs II = 1.19 +/- 0.65, P < .01); standard deviation curvature (I = 0.07 +/- 0.01 vs II = 0.22 +/- 0.21, P = 0.06). The scaled edge-length ratio-the only parameter based on fractal analysis-was not different between the two groups (I = 1.03 +/- 0.01 vs II = 1.13 +/- 0.10, P = ns). Hence, a quantitative description of plaque morphology is feasible and allows an effective discrimination of simple and complex plaque profiles with morphometric parameters based on vector analysis.
Anisotropic Huber-L1 Optical Flow (2009)

TV regularization is an L1 penalization of the flow gradient magnitudes, and due to the tendency of the L1 norm to favor sparse solutions (i.e. lots of ‘zeros’), the fill-in effect caused by the regularizer leads to piecewise constant solutions in weakly textured areas. This effect, known as ‘staircasing’ in a 1D setting, can be reduced significantly by using a quadratic penalization for small gradient magnitudes while sticking to linear penalization for larger magnitudes to maintain the discontinuity preserving properties known from TV. A comparison of isotropic TV and isotropic Huber regularity is shown in Fig. 1 by means of rendering the disparities u1 of the Dimetrodon dataset. The color coded flow (cf. Fig. 1(a)) is superimposed as texture. Based on the two observations that motion discontinuities often occur along object boundaries and that in turn object boundaries often coincide
An in vitro pressure model towards studying the response of primary retinal ganglion cells to elevated hydrostatic pressures (2019)

Glaucoma is a leading cause of blindness characterized by progressive degeneration of retinal ganglion cells (RGCs). A well-established risk factor for the development and progression of glaucoma is elevation of intraocular pressure (IOP). However, how elevated IOP leads to RGC degeneration remains poorly understood. Here, we fabricate a facile, tunable hydrostatic pressure platform to study the effect of increased hydrostatic pressure on RGC axon and total neurite length, cell body area, dendritic branching, and cell survival. The hydrostatic pressure can be adjusted by varying the height of a liquid reservoir attached to a three-dimensional (3D)-printed adapter. The proposed platform enables long-term monitoring of primary RGCs in response to various pressure levels. Our results showed pressure-dependent changes in the axon length, and the total neurite length. The proportion of RGCs with neurite extensions significantly decreased by an average of 38 ± 2% (mean ± SEM) at pressures 30 mmHg and above (p < 0.05). The axon length and total neurite length decreased at a rate of 1.65 ± 0.18 μm and 4.07 ± 0.34 μm, respectively (p < 0.001), for each mmHg increase in pressure after 72 hours pressure treatment. Dendritic branching increased by 0.20 ± 0.05 intersections/day at pressures below 25 mmHg, and decreased by 0.07 ± 0.01 intersections/day at pressures above 25 mmHg (p < 0.001). There were no significant changes in cell body area under different levels of hydrostatic pressure (p ≥ 0.05). Application of this model will facilitate studies on the biophysical mechanisms that contribute to the pathophysiology of glaucoma and provide a channel for the screening of potential pharmacological agents for neuroprotection.
Oxalopeptides as core motifs for protein design (1993)

Oxalopeptides are demonstrated to be useful core motifs for bi-directional chain elongation leading to peptide homologues with interesting folding behaviour, thus constituting a useful strategy for protein backbone modification.
Virtual Chromatographic Resolution Enhancement in Cryoflow LC−NMR Experiments via Statistical Total Correlation Spectroscopy (2007)

A new approach to enhancing information recovery from cryogenic probe "on-flow" LC-NMR spectroscopic analyses of complex biological mixtures is demonstrated using a variation on the statistical total correlation spectroscopy (STOCSY) method. Cryoflow probe technology enables sensitive and efficient NMR detection of metabolites on-flow, and the rapid spectral scanning allows multiple spectra to be collected over chromatographic peaks containing several species with similar, but nonidentical, retention times. This enables 1H NMR signal connectivities between close-eluting metabolites to be identified resulting in a "virtual" chromatographic resolution enhancement visualized directly in the NMR spectral projection. We demonstrate the applicability of the approach for structure assignment of drug and endogenous metabolites in urine. This approach is of wide general applicability to any complex mixture analysis problem involving chromatographic peak overlap and with particular application in metabolomics and metabonomics.
Expression of receptors for native and chemically modified low‐density lipoproteins in brain microvessels (1997)

Despite the importance of cholesterol metabolism in the central nervous system, only relatively few studies have dealt with the cerebral uptake and transport of lipids into the brain compartment. These functions are mediated by the endothelium of brain microvessels, which forms the anatomical basis of the blood-brain barrier. By a reverse transcriptase PCR study of messenger RNA expression we could show, in bovine brain microvessels, the presence of transcripts of native low-density lipoprotein receptor and of both type I and II scavenger receptors. Brain microvessels therefore appear to play an active role in the uptake of native and modified low-density lipoproteins.
FC06.03 Association of serotonin transporter promoter gene variants with clinical features of major depression (2000)

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Extraction Efficiency of an Extraction Buffer Used to Quantify Lysozyme Deposition on Conventional and Silicone Hydrogel Contact Lens Materials (2007)

TFA/ACN is extremely efficient at extracting lysozyme deposited on etafilcon lenses. However, it does not extract all the lysozyme deposited on silicone hydrogel lenses, and alternative extraction procedures should be sought.
Comparative STEREO-LID (spatio-temporally resolved optical laser-induced damage) studies of critical defect distributions in IBS ALD and electron-beam coated dielectric films. (2016)

Abstract not provided.
3-D Adaptive Eulerian-Lagrangian Method for Gravity- and Capillarity-Induced Flows (2009)

Delivery of cryogenic propellants from a spacecraft fuel tank is complicated due to the low and fluctuating gravity level and its interaction with the capillary, convective, and diffusive mechanisms. The present effort is aimed at developing suitable computational modeling techniques capable of offering adequate resolution of moving interfacial dynamics, topological changes due to break-up and merger of the fluid objects, and interactions between phase boundaries and complex solid boundaries. A 3-D adaptive Eulerian- Lagrangian method is developed, utilizing the stationary (Eulerian) frame to resolve the flow field, and the marker-based triangulated moving (Lagrangian) surface meshes to treat the fluid interface. The multiphase fluid boundary is modeled using a continuous interface method, and the solid boundary is treated by a sharp interface method along with the ghost cell method. The performance of the present framework is assessed using several test cases of different challenges, including the (i) sloshing liquid motion by a sudden reduction of acceleration exhibiting substantial variations in the shape and the location of the phase boundary, and (ii) stability of the liquid-gas interface dynamics due to vertically oscillating gravitational acceleration of varying frequency and amplitudes, resulting in complex surface wave patterns. Copyright © 2009 by the American Institute of Aeronautics and Astronautics, Inc.
Mineral Trends in Early Hesperian Lacustrine Mudstone at Gale Crater, Mars (2017)

The Mars Science Laboratory Curiosity rover landed in Gale crater in August 2012 to study the layered sediments of lower Aeolis Mons (i.e., Mount Sharp), which have signatures of phyllosilicates, hydrated sulfates, and iron oxides in orbital visible/near-infrared observations. The observed mineralogy within the stratigraphy, from phyllosilicates in lower units to sulfates in higher units, suggests an evolution in the environments in which these secondary phases formed. Curiosity is currently investigating the sedimentary structures, geochemistry, and mineralogy of the Murray formation, the lowest exposed unit of Mount Sharp. The Murray formation is dominated by laminated lacustrine mudstone and is approx.200 m thick. Curiosity previously investigated lacustrine mudstone early in the mission at Yellowknife Bay, which represents the lowest studied stratigraphic unit. Here, we present the minerals identified in lacus-trine mudstone from Yellowknife Bay and the Murray formation. We discuss trends in mineralogy within the stratigraphy and the implications for ancient lacustrine environments, diagenesis, and sediment sources.
Low-cost quasi-real-time elastography using B-mode ultrasound images (2014)

A low cost, quasi real-time elastography system, displacement-gradient elastography (DGE), was developed by applying digital image correlation (DIC) method and smoothing algorithm to B-mode ultrasound images. In order to achieve quasi real-time elastogram display, a new fast pattern matching algorithm, decoupled cross-correlation (DCC), was proposed and validated. By applying the DGE to various phantoms, elastograms were generated to identify the lesion with wide variations of stiffness ratio and applied strain. The performance of DGE was qualitatively compared with those from a high-end ultrasound scanner using the elastograms of a commercial elastography breast phantom. DGE was also applied to the ultrasound images of human breast lesions in various BI-RADS categories. This study suggests that DGE may have comparable performance to conventional elastography in detecting breast cancer, while it can be easily implemented onto conventional ultrasound scanners.
Autonomic regulation of preterm infants is enhanced by Family Nurture Intervention (2019)

Preterm infants have maturational delays in several neurobehavioral systems. This study assesses the impact of the Family Nurture Intervention (FNI) in the neonatal intensive care unit (NICU) on the maturation of autonomic regulation of preterm infants. Preterm infants born at 26-34 weeks postmenstrual age (PMA) were assigned to groups receiving either standard care (SC) or SC plus FNI, using a randomized controlled trial design. At two collection time points, approximately 35 weeks and 41 weeks PMA, electrocardiograms (ECG) were monitored for approximately 1 hour during sleep. Heart rate and respiratory sinus arrhythmia (RSA) were quantified from the ECG. Across the two time points, the FNI group exhibited greater increases in RSA (Cohen's d = 0.35) and slope between RSA and heart rate, as a measure of vagal efficiency (Cohen's d = 0.62). These results document that FNI resulted in enhanced autonomic regulation consistent with greater maturation of cardiac function. These and previous findings strongly suggest that facilitating early nurturing interactions and emotional connection between preterm infants and their mothers is a practicable and effective means of optimizing postnatal development in preterm infants. Interpretation of these autonomic function results also enriches our understanding of the potential long-term beneficial outcomes of FNI by drawing upon polyvagal theory, which explains how autonomic state provides a neurophysiological platform for optimal co-regulation between infant and caregiver, and by drawing upon calming cycle theory, which provides a model for understanding how repeated mother/infant calming interactions positively condition autonomic state and reinforce approach, prosocial behaviors.
Comparison of Immediate-Release and Controlled Release Carbidopa/Levodopa in Parkinson’s Disease (1997)

During a 5-year treatment period, control of parkinsonian symptoms was maintained by both immediate-release and sustained-release carbidopa/levodopa. Both treatment regimens were associated with a low incidence of motor fluctuations and dyskinesias. There was a statistically significant difference (p < 0.05) in activities of daily living as measured by the UPDRS in favor of Sinemet CR.
Studies on the induction and expression of T cell-mediated immunity. 3. Amplification by papain of the generation of cytotoxic lymphocytes to allogeneic cells. (1974)

We have demonstrated in a recent study (1) that mild proteolytic treatment of immune cytotoxic lymphocytes (CL) 2 leads to a 3- to 5-fold increase in the in vitro cytolytic activity upon target cells bearing the sensitizing antigens. In the present report we describe the potentiation of the generation of CL after treatment of normal lymphoid cells with low concentrations of papain. Thus, BALB/c (H-2 d ) splenocytes treated with papain and subsequently sensitized in vitro or in vivo against allogeneic C57BL/6 (H-2 b ) lymphoid cells exhibit an enhanced specific cytotoxic capacity as compared with untreated cells. Furthermore, the induction of CL with papain-treated cells occurs under conditions in which non-treated cells show little or no reactivity. Materials and Methods. The preparation of spleen cells and enzymatic treatment with papain were described previously (1).
[Studies of lymphocyte activation on late asthmatic response in adult asthma]. (1992)

Late asthmatic response (LAR) as well as delayed asthmatic response (DeAR) is an important clinical characteristic in adult severe asthma. These responses might be based on cell to cell interaction following lymphocyte activation. Therefore, to clarify the pathogenesis of LAR, we studied the lymphocyte functions of adult asthmatics with LAR provoked by inhalation of house dust and Candida antigen. The results revealed that mite antigen-specific lymphocyte blastogenesis, IL-2 and ECF production were significantly higher in asthmatics with LAR provoked by house dust antigen than in normal subjects and asthmatics with IAR by house dust and LAR by Candida, though there was no significant difference in NCF. Candida antigen-specific lymphocyte blastogenesis, IL-2, ECF and NCF production were significantly higher in asthmatics with LAR provoked by Candida antigen than in normal subjects and asthmatics with IAR or LAR provoked by house dust. There was a positive correlation between Candida antigen-specific IL-2 and NCF production in asthmatics with LAR provoked by Candida antigen. These results suggest that antigen-specific lymphocyte activation may play an important role in the pathogenesis of LAR, especially in asthmatics with LAR provoked by Candida antigen, and that LAR and DeAR should be considered inclusively as cell-mediated allergy.
Sol-gel synthesis and spectral characteristics of crystal phosphors Sr2Y8(1 − x)Eu8x Si6O26 (2012)

Solid solutions of the compositions Sr2Y8(1 − x)Eu8x Si6O26 (x = 0.005, 0.01, 0.03, 0.05, 0.1, 0.2, 0.4) based on silicates with the oxyapatite structure have been synthesized using the sol-gel method. The samples have been characterized using X-ray diffraction and energy dispersive X-ray analyses. The morphology of the synthesized solid solutions has been examined. The spectral-luminescent characteristics of crystal phosphors have been investigated.
Facial Infiltrating Lipomatosis (2001)

Facial infiltrating lipomatosis is a rare congenital disorder in which mature lipocytes invade adjacent tissue. The phenotypic features include soft-tissue and skeletal hypertrophy, premature dental eruption, and regional macrodontia. There is a high risk for regrowth after resection that is, perforce, subtotal. The etiology, natural history, optimal management, and relationship to other disorders of fatty overgrowth are unclear. In this study, the clinical features, radiographic findings, histopathology, and postoperative results were analyzed in 13 patients with facial infiltrating lipomatosis. The condition was diagnosed in infancy (eight male subjects, five female subjects) and characterized by enlargement of the cheek (n = 12) or chin (n = 1). Other findings included cutaneous capillary blush (n = 9), ipsilateral macroglossia (n = 8), and mucosal neuromas (n = 6). Most patients had early eruption of ipsilateral deciduous and permanent teeth (n = 12). Computed tomography and magnetic resonance imaging showed an infiltrated soft-tissue mass of fatty density (n = 13) and skeletal overgrowth (n = 9). Multiple resection was performed on six patients (mean number of operations per patient, 2.5; range, one to six operations); regrowth and/or worsening of the capillary stain occurred in all six patients. Because surgical removal of the mass is usually unsuccessful, specific management of this condition will require insight into its etiopathogenesis. Given the presence of mucosal neuromas and lipomatosis, this study included testing for the known mutations in three entities that are associated with these soft-tissue findings (Cowden syndrome, Bannayan-Riley-Ruvalcava syndrome, and multiple endocrine neoplasia type 2B). Results of DNA analyses for these germline mutations were negative. It is more likely that this disorder is caused by a somatic mutation involving a local increase in growth factor(s).
A CLINICAL STUDY ON BOOT CANAL TREATED PATIENTS (1981)

In order to observe the frequency of visits and the distribution of endodontically treated patients according to age, sex, diagnosis, type of teeth, the author had surveyed the 17,250 outpatients of the Infirmary of the College Dentistry, Yonsei University from January 1976 to December 1978. 773 cases, 660 patients among 728 endodontically treated patients were studied. The obtained results were as follow; 1. The average frequency of visits were 5.95 in uppers and 5.88 in lowers. 2. The average frequency of visits were 5.79 in males and 6.02 in females. 3. At the age of under 14, the average frequency of visits were 7.42 in uppers and 6.76 in lowers. 4. According to diagnoses, the average frequency of visits in periapical granuloma or cyst were 2.80 in uppers and 3.16 in lowers. 5. The number of endodontically treated teeth had revealed as follow; upper incisors 27.94%, lower molars 25.87%, and upper molars 15.13% 6. The number of endodontically treated teeth by diagnoses were as follow; periapical abscess 45.27%, pulpit is 37.51%, tooth fracture 8.40%. 7. The number of endodontically treated teeth were 51.99% in the age of from 20 to 34.
Extended Kalman Filtering Applied to a Two-Axis Robotic Arm with Flexible Links (2000)

An industrial robot today uses measurements of its joint positions and models of its kinematics and dynamics to estimate and control its end-effector position. Substantially better end-effector position estimation and control performance would be obtainable if direct measurements of its end-effector position were also used. The subject of this paper is extended Kalman filtering for precise estimation of the position of the end-effector of a robot using, in addition to the usual measurements of the joint positions, direct measurements of the end-effector position. The estimation performances of extended Kalman filters are compared in applications to a planar two-axis robotic arm with very flexible links. The comparisons shed new light on the dependence of extended Kalman filter estimation performance on the quality of the model of the arm dynamics that the extended Kalman filter operates with.
Data from Invasive Lobular Carcinoma Cell Lines Are Characterized by Unique Estrogen-Mediated Gene Expression Patterns and Altered Tamoxifen Response (2023)

&lt;div&gt;Abstract&lt;p&gt;Invasive lobular carcinoma (ILC) is a histologic subtype of breast cancer that is frequently associated with favorable outcomes, as approximately 90% of ILC express the estrogen receptor (ER). However, recent retrospective analyses suggest that patients with ILC receiving adjuvant endocrine therapy may not benefit as much as patients with invasive ductal carcinoma. On the basis of these observations, we characterized ER function and endocrine response in ILC models. The ER-positive ILC cell lines MDA MB 134VI (MM134) and SUM44PE were used to examine the ER-regulated transcriptome via gene expression microarray analyses and ER ChIP-Seq, and to examine response to endocrine therapy. In parallel, estrogen response was assessed &lt;i&gt;in vivo&lt;/i&gt; in the patient-derived ILC xenograft HCI-013. We identified 915 genes that were uniquely E2 regulated in ILC cell lines versus other breast cancer cell lines, and a subset of these genes were also E2 regulated &lt;i&gt;in vivo&lt;/i&gt; in HCI-013. MM134 cells were &lt;i&gt;de novo&lt;/i&gt; tamoxifen resistant and were induced to grow by 4-hydroxytamoxifen, as well as other antiestrogens, as partial agonists. Growth was accompanied by agonist activity of tamoxifen on ER-mediated gene expression. Though tamoxifen induced cell growth, MM134 cells required fibroblast growth factor receptor (FGFR)-1 signaling to maintain viability and were sensitive to combined endocrine therapy and FGFR1 inhibition. Our observation that ER drives a unique program of gene expression in ILC cells correlates with the ability of tamoxifen to induce growth in these cells. Targeting growth factors using FGFR1 inhibitors may block survival pathways required by ILC and reverse tamoxifen resistance. &lt;i&gt;Cancer Res; 74(5); 1463–74. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Age-dependent sensitization to the 7S-vicilin-like protein Cor a 11 from hazelnut (Corylus avellana) in a birch-endemic region. (2012)

Sensitization to Cor a 11 in a birch-endemic region is predominantly found in children with severe hazelnut allergy, a finding that is consistent with observations concerning sensitization to Cor a 9.