gebhart/patrepeval huggingface dataset:
Architectural enhancements in Stratix V™ (2013)

This paper describes architectural enhancements in the Altera Stratix-V" FPGA architecture, built on a 28nm TSMC process, together with the data supporting those choices. Among the key features are time borrowing flip-flops, a doubling of the number of flip-flops per LUT compared to previous Stratix architectures, a simplified embedded 20kb dual-port RAM block, and error correction that can correct up to 8 adjacent errors. Arithmetic performance is significantly improved using a fast adder with two levels of multi-bit skip. We also describe how the routing architecture and layout is optimized for the 28nm process to take advantage of a wider range of wire thicknesses offered on the different layers, and improvements in performance and routability are obtained without dramatic changes to the repeated floorplan of the logic plus routing fabric.
Learning and vision machines (2002)

The problem of learning is arguably at the very core of the problem of intelligence, both biological and artificial. In this paper we review our approach to the problem of visual perception based on supervised learning. After a brief presentation of the theoretical background, we focus on some of the engineering applications of statistical learning to computer vision and discuss the main open problems and directions of our future research.
Conditional restricted Boltzmann machine for voice conversion (2013)

The conventional statistical-based transformation functions for voice conversion have been shown to suffer over-smoothing and over-fitting problems. The over-smoothing problem arises because of the statistical average during estimating the model parameters for the transformation function. In addition, the large number of parameters in the statistical model cannot be well estimated from the limited parallel training data, which will result in the over-fitting problem. In this work, we investigate a robust transformation function for voice conversion using conditional restricted Boltzmann machine. Conditional restricted Boltzmann machine, which performs linear and non-linear transformations simultaneously, is proposed to learn the relationship between source and target speech. CMU ARCTIC corpus is adopted in the experimental validations. The number of parallel training utterances is varied from 2 to 40. For these different training situations, two objective evaluation measures, mel-cepstral distortion and correlation coefficient, both show that the proposed method outperforms the main stream joint density Gaussian mixture model method consistently.
LINDA: a system for loosely integrated databases (2003)

LINDA, an experimental system for database access in heterogeneous environments, is discussed. The goal is to achieve maximum site autonomy and as much database access homogenization as possible. The problems to be solved are discussed, and design priorities are justified. Major heterogeneity problems are sketched, and the applied techniques are briefly described. An overview of the implementation of the system is given, and the system's applicability is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Structure-Activity Relations of New β-Lactam Compounds and in Vitro Activity Against Common Bacteria (1983)

Molecular modifications of the penicillin and cephalosporin nuclei have made it possible to create molecules that more readily cross the outer membranes of bacterial cells, resist destruction by β-lactamases, or bind more avidly to receptors involved in bacterial cell wall synthesis. Penicillin compounds, such as the penicillin mecillinam, owe their activity against gram-negative bacilli to their affinity for a specific penicillin-binding protein (PBP), PBP2. Agents such as apalcillin, azlocillin, mezlocillin, and piperacillin, which are ureido derivatives of ampicillin, are active against many organisms even though they are not β-lactamase-stable because they pass readily through the outer membrane and have a high affinity for PBPs 1 and 3. The methoxyimino cephalosporins, cefotaxime, ceftizoxime, cefmenoxime, and ceftriaxone combine high resistance to hydrolysis by both plasmid and chromosomal β-lactamases with a great affinity for PBPs. The presence of an acid function on the acyl side chain confers both resistance to the cephalosporinases of Pseudomonas and activity against various species to such different compounds as cefsulodin, ceftazidime, and moxalactam. In spite of these changes in structure, which have improved antibacterial activity, organisms resistant to all of the new and novel agents have already been found.
[A case of recurrent abnormal liver function in children resulting from neuroblastoma amplified sequence gene defect]. (2020)

现报道1例6岁男性患儿，临床反复出现肝脏损伤，肝损伤前均有发热，最终诊断为NBAS基因缺陷。与未发现NBAS突变的患者不同，确诊有NBAS突变的患者在每次肝功能损伤前均患有发热性疾病，发热24～72 h后可出现肝功能异常，甚至肝衰竭。以此提醒广大临床医师，反复出现发热相关性肝脏损伤患者应注意NBAS基因缺陷可能。.
Effects of Different Graft Preparation Techniques on the Acute Thrombogenicity of Autologous Vein Grafts (1987)

The effects of different techniques of preparing autologous vein grafts on acute thrombogenicity have been studied in a sheep model. Storing grafts at room temperature or rinsing with different solutions seemed to be of minor importance, whereas distending them to a pressure of 400 mm Hg significantly reduced patency and increased platelet accumulation and thrombus formation.
A Scaffold Switch to Insulate (2012)

Conformational changes in a protein scaffold can determine signaling specificity.
Integrated thin-film dc SQUID sensors (1987)

This paper reviews the design of integrated thin-film dc SQUID sensors fabricated in planar technology. Included are both high performance devices with fully integrated input coils and more advanced devices that incorporate fully integrated pickup loop structures as well, such as gradiometers and miniature susceptometers and magnetometers. First the basic characterization of the dc SQUID is given. Operation and performance issues are discussed followed by a review of the status of planar coupling schemes. A brief discussion of packaging is given. Design considerations for planar gradiometers are presented. The configuration of a balanced coupled SQUID for gradiometer applications is detailed, and some key design concerns for gradiometer arrays are mentioned. The design and application of a miniature SQUID susceptometer is reviewed, and a brief description of several other miniature susceptometer and magnetometer designs is given.
A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray (2010)

Abs are central to malaria immunity, which is only acquired after years of exposure to Plasmodium falciparum (Pf). Despite the enormous worldwide burden of malaria, the targets of protective Abs and the basis of their inefficient acquisition are unknown. Addressing these knowledge gaps could accelerate malaria vaccine development. To this end, we developed a protein microarray containing approximately 23% of the Pf 5,400-protein proteome and used this array to probe plasma from 220 individuals between the ages of 2-10 years and 18-25 years in Mali before and after the 6-month malaria season. Episodes of malaria were detected by passive surveillance over the 8-month study period. Ab reactivity to Pf proteins rose dramatically in children during the malaria season; however, most of this response appeared to be short-lived based on cross-sectional analysis before the malaria season, which revealed only modest incremental increases in Ab reactivity with age. Ab reactivities to 49 Pf proteins measured before the malaria season were significantly higher in 8-10-year-old children who were infected with Pf during the malaria season but did not experience malaria (n = 12) vs. those who experienced malaria (n = 29). This analysis also provided insight into patterns of Ab reactivity against Pf proteins based on the life cycle stage at which proteins are expressed, subcellular location, and other proteomic features. This approach, if validated in larger studies and in other epidemiological settings, could prove to be a useful strategy for better understanding fundamental properties of the human immune response to Pf and for identifying previously undescribed vaccine targets.
Blood lactate monitoring in critically ill patients: A systematic health technology assessment* (2009)

The use of blood lactate monitoring has a place in risk-stratification in critically ill patients, but it is unknown whether the routine use of lactate as a resuscitation end point improves outcome. This warrants randomized controlled studies on the efficacy of lactate-directed therapy.
Supplementary Figure Legend from Cooperative Activity of Cytotoxic Chemotherapy with Antiangiogenic Thrombospondin-I Peptides, ABT-526 in Pet Dogs with Relapsed Lymphoma (2023)

Supplementary Figure Legend from Cooperative Activity of Cytotoxic Chemotherapy with Antiangiogenic Thrombospondin-I Peptides, ABT-526 in Pet Dogs with Relapsed Lymphoma
Cortical Fenestration for Megaprosthesis Stem Revision (2017)

Cortical fenestration is an effective, bone-preserving method of implant extraction, particularly for broken or cemented stems. It is associated with low rates of loosening and no increase in periprosthetic fractures.
An interpretation of objects and object types (1996)

We present an interpretation of typed object-oriented concepts in terms of well-understood, purely procedural concepts. More precisely, we give a compositional subtype-preserving translation of a basic object calculus supporting method invocation, functional method update, and subtyping, into the polymorphic λ-calculus with recursive types and subtyping. The translation techniques apply also to an imperative version of the object calculus which includes in-place method update and object cloning. Finally, the translation easily extends to "Self types" and other interesting object-oriented constructs.
Magneto-optical studies of the 0.88-eV photoluminescence emission in electron-irradiated GaN (2000)

Properties of the 0.88-eV photoluminescence (PL) in electron-irradiated wurtzite GaN have been investigated in detail by a combination of various magneto-optical techniques, including Zeeman measurements of PL, optically detected magnetic resonance (ODMR), and level anticrossing (LAC). ODMR observed by monitoring the PL emission is demonstrated to originate from a spin triplet. The symmetry of the corresponding defect is shown to be rhombic with its principal axes pointing into the high-symmetry directions $Z=[0001],$ $Y=[11\ifmmode\bar\else\textasciimacron\fi{}00],$ and $X=[112\ifmmode\bar\else\textasciimacron\fi{}0].$ From the Zeeman measurements the emission is shown to arise from an optical transition between a singlet excited state and the singlet ground state, providing convincing evidence for indirect detection of the spin triplet ODMR. LAC investigations of the same PL emission reveal two LAC lines, among which one is related to the spin triplet detected in ODMR.
Seguridad y Calidad del suministro electrico. (1995)

La mejora gradual y continua de la Calidad y seguridad del suministro electrico es el objetivo ultimo que deben perseguir las empresas suministradoras y los clientes.
Union Fenosa manteniendo este compromiso con la Calidad viene desarrollando diversas actividades agrupadas en el Plan de Calidad Total, definido en el proceso de Planificacion Estrategica.
Caliper: Performance Introspection for HPC Software Stacks (2016)

Many performance engineering tasks, from long-term performance monitoring to post-mortem analysis and online tuning, require efficient runtime methods for introspection and performance data collection. To understand interactions between components in increasingly modular HPC software, performance introspection hooks must be integrated into runtime systems, libraries, and application codes across the software stack. This requires an interoperable, cross-stack, general-purpose approach to performance data collection, which neither application-specific performance measurement nor traditional profile or trace analysis tools provide. With Caliper, we have developed a general abstraction layer to provide performance data collection as a service to applications, runtime systems, libraries, and tools. Individual software components connect to Caliper in independent data producer, data consumer, and measurement control roles, which allows them to share performance data across software stack boundaries. We demonstrate Caliper's performance analysis capbilities with two case studies of production scenarios.
Application of Defect Conversion Layer by Solution Growth for Reduction of TSDs in 4H-SiC Bulk Crystals by PVT Growth (2019)

We have developed the bulk growth technique to reduce threading screw dislocations (TSDs) by combining solution growth and PVT growth methods. More than 80 % of TSDs in original seed crystals were successfully converted to Frank defects on basal planes by the solution growth on 4° off C-face with Si-5at.% Ti solvent. After PVT growth on the as-grown surface of the conversion layer, TSDs in the original seed were successfully reduced. The presence of micrometer-size macrosteps in the initial stage of PVT growth is important to continue to propagate the converted Frank defects on basal planes during PVT bulk growth.
Role of SGK in hormonal regulation of epithelial sodium channel in A6 cells (2003)

The purpose of this study was to examine the role of the serum- and glucocorticoid-induced kinase (SGK) in the activation of the epithelial sodium channel (ENaC) by aldosterone, arginine vasopressin (AVP), and insulin. We used a tetracycline-inducible system to control the expression of wild-type (SGK(wt)(T)), constitutively active (S425D mutation; SGK(S425D)(T)), or inactive (K130M mutation; SGK(K130M)(T)) SGK in A6 cells independently of hormonal stimulation. The effect of SGK expression on ENaC activity was monitored by measuring transepithelial amiloride-sensitive short-circuit current (I(sc)) of transfected A6 cell lines. Expression of SGK(wt)(T) or SGK(S425D)(T) and aldosterone stimulation have additive effects on I(sc). Although SGK could play some role in the aldosterone response, our results suggest that other mechanisms take place. SGK(S425D)(T) abrogates the responses to AVP and insulin; hence, in the signaling pathways of these hormones there is a shared step that is stimulated by SGK. Because AVP and insulin induce fusion of vesicles to the apical membrane, our results support the notion that SGK promotes incorporation of channels in the apical membrane.
Localization of electromagnetic fields in disordered metamaterials (2012)

We study the effects of disorder in planar metamaterials consisting of strongly interacting metamolecules, where coupled electric dipole and magnetic dipole modes give rise to a Fano-type resonant response, and show that positional disorder leads to light localization inherently linked to collective magnetic dipole excitations. We demonstrate that the magnetic excitation persists in disordered arrays and results in the formation of ``magnetic hot spots.''
Selective Depletion of Molecularly Defined Cortical Interneurons in Human Holoprosencephaly with Severe Striatal Hypoplasia (2009)

Cortical excitatory glutamatergic projection neurons and inhibitory GABAergic interneurons follow substantially different developmental programs. In rodents, projection neurons originate from progenitors within the dorsal forebrain, whereas interneurons arise from progenitors in the ventral forebrain. In contrast, it has been proposed that in humans, the majority of cortical interneurons arise from progenitors within the dorsal forebrain, suggesting that their origin and migration is complex and evolutionarily divergent. However, whether molecularly defined human cortical interneuron subtypes originate from distinct progenitors, including those in the ventral forebrain, remains unknown. Furthermore, abnormalities in cortical interneurons have been linked to human disorders, yet no distinct cell population selective loss has been reported. Here we show that cortical interneurons expressing nitric oxide synthase 1, neuropeptide Y, and somatostatin, are either absent or substantially reduced in fetal and infant cases of human holoprosencephaly (HPE) with severe ventral forebrain hypoplasia. Notably, another interneuron subtype normally abundant from the early fetal period, marked by calretinin expression, and different subtypes of projection neuron were present in the cortex of control and HPE brains. These findings have important implications for the understanding of neuronal pathogenesis underlying the clinical manifestations associated with HPE and the developmental origins of human cortical interneuron diversity.
Role of Digestive Enzymes in Fish Larval Nutrition (2020)

The aquaculture industry is dependent upon the continuous availability of quality juveniles of fish species for culture that in turn depend on the survival and growth of the fish larvae. Attempt to supply enzymes in artificial diets to fish larvae to improve digestion demonstrated elevated levels of gut enzyme activity but no improvement in growth. Greater emphasis has been placed in fish larval nutrition studies, where enzyme profiles are used to formulate appropriate diets. It is also known that trypsin specific activity in fish larvae is related to feed intake and nature of dietary protein or nature of weaning diets. This long period of slow growth could be reduced by the stimulation of digestive enzymes secretion by growth promoters/feed additives. It has been suggested that diets containing oligopeptides better correspond to the digestive features of fish larvae allowing a better nutritional status and then an adequate postnatal development.
Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis (2015)

The diverse morphology of vertebrate skeletal system is genetically controlled, yet the means by which cells shape the skeleton remains to be fully illuminated. Here, we perform a quantitative analysis of cell behaviors in the growth plate cartilage, the template for long bone (limb skeleton) formation, to gain insights into this process. The proliferative zone (PZ) is comprised of elliptical chondrocytes aligned perpendicular to the proximal‐distal axis (PDA) of the tissue, suggesting some coordination between oriented cell behaviors and oriented tissue growth. Using a robust avian embryonic organ culture, we employ time‐lapse two‐photon laser scanning microscopy to observe PZ cell behaviors during cartilage elongation in 4D (xyz and t). These time‐lapse movies reveal distributed growth in the PZ, resulting in cell trajectories with a spreading displacement mainly along the PDA. We build a novel software toolkit of quantitative methods to segregate the contributions of various cellular morphogenetic processes that contribute to the cell trajectories. Surprisingly, convergent extension (CE) and cellular column formation are not the major contributors of the stages examined; instead, the analyses reveal important roles of extracellular matrix (ECM) deposition and cell volume enlargement.
Regional insertional mutagenesis on chromosome III of Arabidopsis thaliana using the maize Ac element (1998)

The authors describe the production and characterization of a collection of Arabidopsis lines each carrying a transposed Ac (trAc) element. A total of 507 lines were obtained following germinal transpositions of a single Ac element located on the upper portion of chromosome III. Southern analysis revealed that up to 90% of the lines in this collection harbour distinct insertions of Ac in the Arabidopsis genome. As previous studies on the behaviour of Ac in Arabidopsis have indicated that approximately two out of three transposition events occur to linked loci, the authors hypothesized that this collection could be of great use in isolating insertional mutants for genes located in the vicinity of the donor locus. PCR and phenotypic screens were performed to identify mutations in five loci located within a 40 cm region of chromosome III centered on the donor locus. Molecular analyses confirmed the presence of germinal insertions of Ac in three of the loci (NPTII, ABI3 and EST #210A22). At a fourth locus (AtDMC1), despite the absence of a germinal insertion, one line in which somatic insertions occurred regularly was identified and may be of use in isolating a germinal insertion. This collection of trAc lines constitutes a useful complement to the existing collection of T-DNA insertion lines and will soon be made available through the Arabidopsis Biological Resource Center.
LSST camera optics (2006)

The Large Synoptic Survey Telescope (LSST) is a unique, three-mirror, modified Paul-Baker design with an 8.4m primary, a 3.4m secondary, and a 5.0m tertiary feeding a camera system that includes corrector optics to produce a 3.5 degree field of view with excellent image quality (<0.3 arcsecond 80% encircled diffracted energy) over the entire field from blue to near infra-red wavelengths. We describe the design of the LSST camera optics, consisting of three refractive lenses with diameters of 1.6m, 1.0m and 0.7m, along with a set of interchangeable, broad-band, interference filters with diameters of 0.75m. We also describe current plans for fabricating, coating, mounting and testing these lenses and filters.
Necessity of an emulator to validate new resources allocation protocols (2002)

Sharing resources between several users is a need for bandwidth usage optimisation, as well as a challenge for allocation algorithms and protocols (referred to as MAC protocols). The efficiency of the MAC (medium access control) is of major importance for the performances of the supported applications. Furthermore, these application protocols are too many and too complex to be properly analysed and modelled when designing the radio segment. Only a real time connection of the application protocols on an emulated MAC can highlight possible misbehaviours or bad performances. In order to validate new protocols included in radio-mobile networks, we chose to develop an emulator of the General Packet Radio Service (GPRS), the POTOMAC (Protocol Observation Tool for the Optimisation of MAC layers). Each protocol of the stack, for example the radio resource allocation, can be individually focused on and its influence on service performance can be evaluated. Furthermore, the behaviour of application protocols when supported by the radio segment can be analysed.