gebhart/patrepeval huggingface dataset:
Practical design methods for ATM systems (2000)

The basic service categories necessary for the information highway, namely, VLL (virtual leased line), VCS (virtual circuit switching), COPS (connection oriented packet switching), and CLPS (connectionless packet switching), have been proposed [9]. In this paper, we propose simplified practical design and control methods for the ATM systems to implement these categories of service. VLL may be realized by a cross-connecting technology of transmission systems. For VCS, the transmission speed is designed so as to satisfy the average call loss rate by applying a multidimensional traffic model. For COPS, using the call blocking probability as the call level QoS (quality of service), the maximum number of virtual channels (VCs) is designed to satisfy the QoS requirement. With the cell level QoS, the cell loss rate and mean cell delay, the transmission line speed and the buffer size are designed to satisfy the QoS requirement. In a system integrating COPS and CLPS, COPS is given nonpreemptive priority over CLPS, the latter being served on a best effort basis. In overload traffic conditions, a control method is proposed in which the number of assigned VCs is reduced so as to meet the cell level QoS requirement. © 2000 Scripta Technica, Electron Comm Jpn Pt 1, 83(10): 1–10, 2000
Matrilysin (MMP-7) promotes invasion of ovarian cancer cells by activation of progelatinase (2004)

Although matrilysin (MMP-7) is overexpressed in various malignancies, few studies have evaluated its role in epithelial ovarian cancer (EOC) invasion and metastasis. We report that the secretion of MMP-7 in EOC is stimulated significantly by vascular endothelial growth factor (VEGF) and interlukin-8 (IL-8). We also examined the in vivo expression of MMP-7 in EOC and its effects on the in vitro invasion and progelatinase activation. We report that MMP-7 is overexpressed in ovarian cancer cell lines and EOC surgical specimens. DOV13 cells incubated with active rhMMP-7 significantly increased cellular invasion and proMMP-2 activation. RhMMP-7 also showed the ability to activate proMMP-2 and proMMP-9 in immortalized ovarian epithelial cell (IOSE-29) conditioned medium. In addition, rhMMP-7 was able to activate progelatinase in a concentration-dependent manner in vitro. TIMP-2 or the generic MMP inhibitor-GM6001 inhibited both the activation of proMMP-2 and the increased invasion of DOV13 cells promoted by rhMMP-7. By incubation of MMP2-TIMP-2 complex with equal molar rhMMP-7, MMP-2 was dissociated from the complex and activated in a time-dependent manner, suggesting that TIMP-2 helps to keep the latency of MMP-2. TIMP-2 also showed inhibitory effects on the MMP-7 induced increase of gelatinolytic activity in DOV13 and IOSE-29 conditioned media. A strong co-localization of MMP-7 and MMP-2 was observed in DOV13 cells and ovarian carcinoma permanent tissue sections. These results indicate MMP-7 is overexpressed in malignant ovarian epithelium and suggest MMP-7 may facilitate tumor cell invasion in vivo partly through the induction of progelatinase activation.
Enantioselective Titanium(III)‐Catalyzed Reductive Cyclization of Ketonitriles (2012)

Reduction, please! The title reaction affords α-hydroxyketones, a common structural motif in biologically active natural products, in good yields and high enantioselectivities at room temperature. The commercially available ansa-titanocene 1 was found to be an efficient catalyst for this process, which presumably proceeds by addition of a ketyl radical to a nitrile.
Description of Anaerobaculum hydrogeniformans sp. nov., an anaerobe that produces hydrogen from glucose, and emended description of the genus Anaerobaculum (2011)

A novel anaerobic, moderately thermophilic, NaCl-requiring fermentative bacterium, strain OS1T, was isolated from oil production water collected from Alaska, USA. Cells were Gram-negative, non-motile, non-spore-forming rods (1.7-2.7×0.4-0.5 µm). The G+C content of the genomic DNA of strain OS1T was 46.6 mol%. The optimum temperature, pH and NaCl concentration for growth of strain OS1T were 55 °C, pH 7 and 10 g l(-1), respectively. The bacterium fermented D-fructose, D-glucose, maltose, D-mannose, α-ketoglutarate, L-glutamate, malonate, pyruvate, L-tartrate, L-asparagine, Casamino acids, L-cysteine, L-histidine, L-leucine, L-phenylalanine, L-serine, L-threonine, L-valine, inositol, inulin, tryptone and yeast extract. When grown on D-glucose, 3.86 mol hydrogen and 1.4 mol acetate were produced per mol substrate. Thiosulfate, sulfur and L-cystine were reduced to sulfide, and crotonate was reduced to butyrate with glucose as the electron donor. 16S rRNA gene sequence analysis indicated that strain OS1T was related to Anaerobaculum thermoterrenum (99.7 % similarity to the type strain), a member of the phylum Synergistetes. DNA-DNA hybridization between strain OS1T and A. thermoterrenum DSM 13490T yielded 68 % relatedness. Unlike A. thermoterrenum, strain OS1T fermented malonate, maltose, tryptone, L-leucine and L-phenylalanine, but not citrate, fumarate, lactate, L-malate, glycerol, pectin or starch. The major cellular fatty acid of strain OS1T was iso-C15:0 (91 % of the total). Strain OS1T also contained iso-C13:0 3-OH (3 %), which was absent from A. thermoterrenum, and iso-C13:0 (2 %), which was absent from Anaerobaculum mobile. On the basis of these results, strain OS1T represents a novel species of the genus Anaerobaculum, for which the name Anaerobaculum hydrogeniformans sp. nov. is proposed. The type strain is OS1T (=DSM 22491T=ATCC BAA-1850T). An emended description of the genus Anaerobaculum is also given.
Introduction (2011)

Graph theory is a well-studied discipline as are the fields of natural language processing and information retrieval. Traditionally, these areas of study have been perceived as distinct, with different algorithms, different applications, and different potential end-users. However, as recent research work has shown, these disciplines in fact are intimately connected, with much variety in the way that natural language processing and information retrieval applications find efficient solutions within graph-theoretical frameworks.
Hypolipidemic and Hepatoprotective Effects of High-Polydextrose Snack Food on Swiss Albino Mice (2020)

In this study, the hepatoprotective and hypolipidemic effects of high-polydextrose snack food on Swiss albino mice were investigated. The mice were randomly divided into three groups: control diet, high-fat diet, and high-fat and fiber diet groups. Addition of high-polydextrose snack to the high-fat diet resulted in significant reduction in the liver weight, the accumulation of lipid droplets in liver, and the liver damage of hyperlipidemic mice in comparison with the high-fat diet. The high-polydextrose snack also decreased the content of total triglyceride, cholesterol, and low-density lipoprotein cholesterol as well as the alanine aminotransferase and aspartate aminotransferase activities in the mice serum. In addition, the high-polydextrose snack significantly increased the high-density lipoprotein cholesterol content of the hyperlipidemic mice. Consequently, use of high-polydextrose snack generated hepatoprotective and hypolipidemic effects on hyperlipidemic mice.
Using design patterns to support migration between different system architectures (2010)

Complex software is a key part of many safety-critical embedded systems. Changes to such software over the system lifetime or to support product upgrades - particularly in applications which require realtime behaviour - can be a costly, time consuming, and risky process, requiring detailed re-testing and even recertification. This paper begins to explore ways in which techniques known as “design patterns” can be used to support the required migration processes. The particular focus of the work described in this paper is on migration between “event triggered” and “time triggered” software architectures.
Intuitive and Efficient Roof Modeling for Reconstruction and Synthesis (2021)

We propose a novel and flexible roof modeling approach that can be used for constructing planar 3D polygon roof meshes. Our method uses a graph structure to encode roof topology and enforces the roof validity by optimizing a simple but effective planarity metric we propose. This approach is significantly more efficient than using general purpose 3D modeling tools such as 3ds Max or SketchUp, and more powerful and expressive than specialized tools such as the straight skeleton. Our optimization-based formulation is also flexible and can accommodate different styles and user preferences for roof modeling. We showcase two applications. The first application is an interactive roof editing framework that can be used for roof design or roof reconstruction from aerial images. We highlight the efficiency and generality of our approach by constructing a mesh-image paired dataset consisting of 2539 roofs. Our second application is a generative model to synthesize new roof meshes from scratch. We use our novel dataset to combine machine learning and our roof optimization techniques, by using transformers and graph convolutional networks to model roof topology, and our roof optimization methods to enforce the planarity constraint.
Chemical Structures Formed in Electron Beam Irradiated Poly(tetrafluoroethylene‐co‐hexafluoropropylene) (FEP) (2006)

Abstract Summary: The perfluorinated copolymer poly(tetrafluoroethylene‐ co ‐hexafluoropropylene) (FEP) was electron beam irradiated under vacuum at various temperatures ranging from room temperature to a temperature above the melting temperature of FEP. Changes of the chemical structure were analyzed by 19 F solid‐state NMR and IR spectroscopy. Trifluoromethyl end groups were generated as a result of main chain scission at all irradiation temperatures studied. In addition, trifluoromethyl side groups in various environments and double bond structures were formed. Quantitative analysis showed that long‐chain branches were formed at irradiation temperatures above 200 °C. Furthermore, the hexafluoropropylene (HFP) units in FEP were found to be less sensitive to radiation than the perfluoropropyl vinyl ether (PPVE) units in poly[tetrafluoroethylene‐ co ‐(perfluoropropyl vinyl ether)] (PFA). 19 F solid‐state NMR spectra of FEP. magnified image 19 F solid‐state NMR spectra of FEP.
A concurrent approach for testing address decoder faults in eFlash memories (2007)

The evolution of system-on-chip (SoC) designs involves the development of non-volatile memory technologies like Flash. As any kind of memories, embedded Flash (eFlash) can be subjected to complex functional faults that are related to their particular technological process and to their integration density. In this paper, we address a major issue during eFlash testing, namely the test of Address decoder Faults (AFs), which is generally very time consuming with ad-hoc solutions presently used in industry. In the first part of the paper, we show the impact of AFs on the functional behavior of an eFlash. Next, we use an analogy with RAM memory testing to classify AFs with respect to their functional behavior. We then obtain AFs acting either as stuck-at faults or as state coupling faults. In the fourth part of the paper, we propose a concurrent approach for testing AFs acting on either the word line decoder or the bit line decoder. The proposed approach allows using a minimal number of programming operations during test application. Finally, we propose a compaction procedure to further reduce the test time of AFs. As a result, huge reductions in test time can be achieved; experiments on a 4 Mbits eFlash have shown that a test time reduction factor of 34x can be obtained when compared to the global eFlash test flow presently used in industry. An additional important feature of the proposed strategy is that it allows testing 100% of other critical faults in eFlashs (stuck-at, transition and state coupling faults) beside full coverage of AFs.
Direct observation of the unstable intermediates in radical addition reaction by using an interfacing microchip combined with an NMR (2007)

Direct observation of the unstable intermediate in the radical addition reaction of the oxime ether 1 mediated by triethylborane (Et(3)B) is described using (1)H and (11)B micro channeled cell for synthesis monitoring (MICCS), which was recently developed as an interfacing microchip for NMR. It was possible that the signal of the intermediate was observed as a result of using MICCS technique with a standard NMR instrument. This result supports the structure of the intermediate analyzed by diffusion-ordered spectroscopy (DOSY) NMR method in a previous paper. The procedure of micro channeled cell for synthesis monitoring-nuclear magnetic resonance (MICCS-NMR) was much easier than that of DOSY method. It was proven that it could be applied to the reaction in an anhydrous condition.
One‐Pot Synthesis of 2,3‐Disubstituted N‐Tosylindoles from o‐Acyl‐N‐tosylanilines. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Supplementary Figure 1 from A New Nonestrogenic Steroidal Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type I Blocks the Estrogen-Dependent Breast Cancer Tumor Growth Induced by Estrone (2023)

&lt;p&gt;PDF file, 68K, Effect of PBRM, an inhibitor of 17b-HSD 1, and estrone (E1) on the body (A), uterine (B) and vaginal (C) weight of ovariectomized nude mice after 32 days of treatment. CTR: control.&lt;/p&gt;
A Cationic Metal–Organic Solid Solution Based on Co(II) and Zn(II) for Chromate Trapping (2013)

We report the synthesis and characterization of a solid solution series of cationic metal–organic materials with full compositional range from pure Co(II) to Zn(II) end-members. The materials consist of [ZnxCo1–x(H2O)4(4,4′-bipy)2]2+ metal–organic clusters that π–π stack into 2-D positively charged layers, with the metal ratio tunable by molar ratio under hydrothermal conditions. The interlamellar α,ω-alkanedisulfonate serves as an anionic template and noncovalently interacts with the cationic layers. The weak interaction allows anion exchange for toxic oxometal anions, such as chromate, CrO42–. The highest chromate adsorption capacity was 68.5 mg/g (0.43 mol/mol) for the as-synthesized 50 mol % Co(II)-incorporated material. Our cationic material can also selectively trap these toxic oxo-anions when nontoxic anions (e.g., nitrate, sulfate) were present in an over 50-fold excess concentration.
A functional screen of translated pancreatic lncRNAs identifies a microprotein-independent role for LINC00261 in endocrine cell differentiation (2020)

Abstract Long noncoding RNAs (lncRNAs) are a heterogenous group of RNAs, which can encode small proteins. The extent to which developmentally regulated lncRNAs are translated and whether the produced microproteins are relevant for human development is unknown. Here, we show that many lncRNAs in direct vicinity of lineage-determining transcription factors (TFs) are dynamically regulated, predominantly cytosolic, and highly translated during pancreas development. We genetically ablated ten such lncRNAs, most of them translated, and found that nine are dispensable for endocrine cell differentiation. However, deletion of LINC00261 diminishes generation of insulin + endocrine cells, in a manner independent of the nearby TF FOXA2 . Systematic deletion of each of LINC00261 ’s seven poorly conserved microproteins shows that the RNA, rather than the microproteins, is required for endocrine development. Our work highlights extensive translation of lncRNAs into recently evolved microproteins during human pancreas development and provides a blueprint for dissection of their coding and noncoding roles. Graphical Abstract Highlights Extensive lncRNA translation and microprotein production during human pancreas development A small-scale loss-of-function screen shows most translated lncRNAs are dispensable LINC00261 is highly translated and regulates endocrine cell differentiation Deleting LINC00261 ’s evolutionary young microproteins reveals no essential roles
Discussion (2007)

Houston, Texas Received for publication December 2, 2005. Steven J. Kronowitz, M.D., The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 443, Houston, Texas 77030, [email protected]
Some Derivatives and Analogs of 4-Biguanidophenylarsonic Acid1 (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Derivatives and Analogs of 4-Biguanidophenylarsonic Acid1Robert L. McGeachinCite this: J. Am. Chem. Soc. 1953, 75, 4, 973–975Publication Date (Print):February 1, 1953Publication History Published online1 May 2002Published inissue 1 February 1953https://doi.org/10.1021/ja01100a059RIGHTS & PERMISSIONSArticle Views56Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (396 KB) Get e-Alerts Get e-Alerts
Residual inhibition: From the putative mechanisms to potential tinnitus treatment (2019)

Neurons in various sensory systems show some level of spontaneous firing in the absence of sensory stimuli. In the auditory system spontaneous firing has been shown at all levels of the auditory pathway from spiral ganglion neurons in the cochlea to neurons of the auditory cortex. This internal "noise" is normal for the system and it does not interfere with our ability to perceive silence or analyze sound. However, this internal noise can be elevated under pathological conditions, leading to the perception of a phantom sound known as tinnitus. The efforts of many research groups, including our own, led to the development of a mechanistic understanding of this process: After cochlear insult the input to the central auditory system becomes markedly reduced. As a result, the neural activity in the central auditory system is enhanced to compensate for this reduced input. Such hyperactivity is hypothesized to be interpreted by the brain as a presence of sound. This implies that suppression of hyperactivity should reduce/eliminate tinnitus. This review explores research from our laboratory devoted to identifying the mechanism underlying residual inhibition of tinnitus, a brief suppression of tinnitus following a sound stimulus. The key mechanisms that govern neural suppression of spontaneous activity in animals closely resemble clinical psychoacoustic findings of residual inhibition (RI) observed in tinnitus patients. This suppression is mediated by metabotropic glutamate receptors (mGluRs). Lastly, drugs targeting mGluRs suppress spontaneous activity in auditory neurons and reduce/eliminate behavioral signs of tinnitus in mice. Thus, these drugs are therapeutically relevant for tinnitus suppression in humans.
Coverage of Chest Wall and Pelvic Defects with the External Oblique Musculofasciocutaneous Flap (1988)

The external oblique muscle, its fascia, and overlying skin have comprised flaps that have been used successfully in reconstructive surgery of various defects in the past. This flap provides good coverage for lower and upper chest wall defects to the level of the ipsilateral fourth rib. It provides skin of a similar color and texture and of large quantity. The skin of the flap is innervated; thus, sensation can be maintained. The remaining flat abdominal musculature and fascia maintain the integrity of the abdominal wall after transposition. We demonstrate that the external oblique musculofasciocutaneous flap can also be rotated in an inferior direction to close large hemipelvectomy defects in the absence of the usual ipsilateral thigh musculature.
Location-Based Authentication and Authorization Using Smart Phones (2012)

Authentication and authorization are two of the most important security features for mobile transaction systems. Most commonly, these schemes depend on three factors: what you know (secret), what you have (token), and what you are (biometrics). In this paper, we propose a location-based authentication and authorization scheme for mobile transactions using smart phones. The paper first describes the distinguished features and the architecture of our proposed solution. Second, the core of our design, including three parts: location registration, authentication and authorization as well as location verification, are described.
The Regulation of Platelet-activating Factor Production in Endothelial Cells (1989)

Endothelial cells (EC) synthesize platelet-activating factor (PAF) when stimulated with agonists that bind to cell-surface receptors. We examined events that link receptor binding to synthesis of PAF by EC. Bovine EC stimulated with agonists that interact with specific cell-surface receptors accumulated PAF only in the presence of extracellular calcium. Hormonal stimulation of EC resulted in Ca2+ entry characteristic of that seen with receptor-operated calcium channels; Indo-1 measurements demonstrated that this inward flux of Ca2+ caused prolonged elevated levels of intracellular Ca2+. EC were exposed to melittin or theta toxin from Clostridium perfringens (pore-forming peptides that increase the permeability of the plasma membrane for small molecules) resulting in an inward flux of Ca2+ and accumulation of PAF. Ca2+ appears to be regulatory for PAF production at the level of phospholipase A2-mediated production of the PAF precursor 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine, as Ca2+ was required for the stimulated hydrolysis of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine. PAF accumulation in EC is also regulated by protein kinase C. Pretreatment of EC with phorbol esters that activate protein kinase C or with dioctanoylglycerol, followed by stimulation, resulted in a 2-fold increase in stimulated PAF production. The regulatory effect of protein kinase C also appears to be at a phospholipase A2-mediated hydrolysis of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine.
An Overview of Hepatitis B Virus Surface Antigen Secretion Inhibitors (2018)

Current anti-hepatitis B virus (HBV) regimen do not meet ideal result due to emerging resistance strains, cytotoxicity, and unfavorable adverse effects. In chronic HBV infection, high rates of sub-viral particles (SVPs) bearing HBV surface antigen (HBsAg) is a major obstacle regarding to raise effective immune responses and subsequently virus clearance. Development of potent HBsAg secretion inhibitors would provide a better insight into HBV immunopathogenesis and therapy. Investigating new non-toxic HBsAg secretion inhibitors targeting either viral or cellular factors could restore the immune response to remove virally infected hepatocytes after inhibiting SVPs. In this study, we overview several classes of HBV inhibitors with focus on their limitations and advantages over anti-HBsAg secretion potential.