gebhart/patrepeval huggingface dataset:
ATTEMPTS TO FIND NEW ANTIMALARIALS. VI. SOME HETEROCYCLIC SULFANILAMIDE DERIVATIVES1 (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTATTEMPTS TO FIND NEW ANTIMALARIALS. VI. SOME HETEROCYCLIC SULFANILAMIDE DERIVATIVES1LEWIS J. SARGENT and LYNDON SMALLCite this: J. Org. Chem. 1946, 11, 2, 179–181Publication Date (Print):March 1, 1946Publication History Published online1 May 2002Published inissue 1 March 1946https://doi.org/10.1021/jo01172a010RIGHTS & PERMISSIONSArticle Views84Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (213 KB) Get e-Alerts Get e-Alerts
Active control of structures using macro-fiber composite (MFC) (2007)

This paper presents the use of macro-fiber composites (MFC) for vibration reduces of structures. The MFC consist of polyimid films with IDE-electrodes that are glued on the top and the bottom of rectangular piezoceramic fibers. The interdigitated electrodes deliver the electric field required to activate the piezoelectric effect in the fibers and allows to invoke the stronger longitudinal piezoelectric effect along the length of the fibers. When this actuator embedded in a surface or attached to flexible structures, the MFC actuator provides distributed solid-state deflection and vibration control. The major advantages of the piezoelectric fibre composite actuators are their high performance, flexibility, and durability when compared with the traditional piezoceramic (PZT) actuators. In addition, the ability of MFC devices to couple the electrical and mechanical fields is larger than in monolithic PZT. In this study, we showed the experimental results that an MFC could be used as actuator to find modal parameters and reduce vibration for structures such as an aluminium beam and metal music plate. Two MFC actuators were attached to the surfaces of test subjects. First MFC actuator used to supply a signal as exciter of vibration and second MFC show his application for reduction of vibration in the range of resonance frequencies. Experimental results of aluminium beam with MFC actuators compared with finite element model which modelled in ANSYS software. The applied voltage is modelled as a thermal load according to thermal analogy for MFC. The experimental and numerical results presented in this paper confirm the potential of MFC for use in the vibration control of structures.
Usefulness of cut‐off points of International criteria for prediction of post‐partum diabetes and prediabetes among Chinese women with gestational diabetes (2021)

Among Chinese women with GDM, fasting PG ≥ 5.1 mmol/L was associated with post-partum diabetes without any discernible threshold effects while 2-h PG ≥ 8.5 and ≥ 9.0 mmol/L respectively identified women at high risk of post-partum prediabetes and diabetes.
Ubiquitous Elevation of Matrix Metalloproteinase-2 Expression in the Vasculature of Patients With Abdominal Aneurysms (2001)

Patients with AAA have elevated MMP-2 levels in the vasculature remote from the aorta. This finding is due to increased MMP-2 expression from SMCs, a characteristic maintained in tissue culture. These data support both the systemic nature of aneurysmal disease and a primary role of MMP-2 in aneurysm formation.
Enantioselective Tsuji Allylations (2007)

The family of allylation reactions developed by Tsuji in the 1980s are capable of generating tertiary and quaternary carbon stereocenters from several synthetic precursors. Despite the utility of these transformations, they have seen little use in the synthesis of natural products. Recently, the power of these reactions was significantly enhanced by the development of enantioselective versions of these transformations. Applications of these methods to the enantioselective syntheses of natural products and pharmaceutical compounds highlight the importance of these developments.
Faculty Opinions recommendation of A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster. (2018)

A complete adult Drosophila brain was imaged with EM and has been made publicly available d The imaged volume enables brain-spanning mapping of circuits at synaptic resolution d All mushroom body (MB) calyx inputs were mapped, revealing a new cell type, MB-CP2
Can Overmarking Be Considered as a Means of Chemical Mate Guarding in a Wild Callitrichid? (2010)

Mate guarding is a male strategy to monopolize matings and thus to ensure paternity. Since in callitrichids female reproductive status is advertised by scent marks, one may expect mate guarding by chemical means. We addressed this question during an episode of consortship observed in a polyandrous trio of wild saddleback tamarins (Saguinus fuscicollis). During consortship, the consort male was the only one to allomark the female. Scent marking frequency decreased for all individuals, although the consort male marked more than the other male during consortship, while there was no difference in the previous period. During consortship, almost 50% of female scents were overmarked by the consort, and more than 56% of the consort's scent marks were employed to overmark the female's scents. Therefore, the other male had limited access to female scent marks. Mate guarding may thus have a chemical component in tamarins, and olfactory communication may play an important role in mating competition.
ChemInform Abstract: SYNTHETIC METHODS AND REACTIONS. PART 50. REARRANGEMENT OF ALLYL ALCOHOLS TO ALDEHYDES WITH SUPERACIDS (1979)

Abstract Mit Supersäuren, z.B. Fluorsulfonsäure‐Antimonpenta‐ fluorid und Sulfurylchloridfluorid, werden A1lylalkohole, z.B. (I), über entsprechende Oxonium‐Ionen zu Aldehyden, z.B. (II), isomerisiert.
Interactive constrained frequent-pattern mining system (2004)

Data mining refers to the search for implicit, previously unknown, and potentially useful information (such as frequent patterns) that might be embedded in data. Most of the existing data mining algorithms do not allow users to express the patterns to be mined according to their intention via the use of constraints. Consequently, these unconstrained mining algorithms can yield numerous patterns that are not interesting to users. Moreover, data mining is supposed to be an exploratory process. In this context, we are working on a project with the objective of implementing an efficient, interactive, human-centered system for mining frequent patterns that satisfy the user constraints. We develop such a system, called iCFP, for interactive mining of constrained frequent patterns. Our developed system uses a tree-based mining framework. In addition, it (i) allows human users to impose a certain focus on the mining process, (ii) provides users with feedback during the mining process, and (iii) permits users to dynamically change their constraints during the process.
COMPARTMENTAL ARRANGEMENT OF STEROID PRECURSORS AND THE CONTROL OF STEROID HORMONE SECRETION IN RAT ADRENAL TISSUE IN VITRO (1971)

ABSTRACT Using a technique of incubation with dialysis, capsules (zona glomerulosa) and inner zone preparations of adrenal tissue from control, cortisol treated and Frusemide treated rats have been studied. The formation of corticosterone, deoxycorticosterone and 18-hydroxydeoxycorticosterone from both endogenous precursors and from added [ 14 C] progesterone was examined. In the inner zone incubations from control and cortisol treated rats, products from the two precursor types appeared to be quite miscible as judged by their dialysability. Cortisol treatment depressed the formation of all three products from endogenous precursors, while their formation from [14C] progesterone was unaffected. These findings are consistent with the conventional view of the major point of action of ACTH at a stage preceding pregnenolone formation. In contrast, the formation of corticosterone from endogenous precursors in the capsule was specifically depressed by cortisol treatment. The formation of deoxycorticosterone and 18-hydroxydeoxycorticosterone was unaffected; the yields of all three compounds from [ 14 C] progesterone was also unaffected. At the same time the dialysibility of the material formed from endogenous precursors was greatly reduced, while the dialysibility of the radioactive products was unchanged. In the Frusemide treated animals, capsule incubations showed no changes in formation of steroids from either precursor type and the miscibility of the steroid from the two sources was unaffected. In the inner zone incubations the formation of deoxycorticosterone and corticosterone was increased from both precursors, while the formation of 18-hydroxydeoxycorticosterone was reduced from endogenous precursors and unchanged from [ 14 C] progesterone. Dialysibility of the steroids was unaffected by these procedures. The results suggest that various mechanisms may operate to allow independent variations in secretion rates of compounds occurring after the point of pregnenolone formation – normally held to be the major point of ACTH action. In particular it appears that, when ACTH secretion is suppressed, steroid formed from endogenous precursors may become attached to a non-dialysable component in the capsule of the gland. It is an attractive hypothesis that this renders the steroid less vulnerable to 11β-hydroxylation although it remains vulnerable to 21- and 18-hydroxylation. This mechanism is not observed if products from [ 14 C] progesterone are studied alone. Treatment with Frusemide shows that other mechanisms may also allow differential changes in secretion rates of the three compounds. These mechanisms await elucidation.
Longitudinal pattern of regional brain volume change differentiates normal aging from MCI (2009)

Although age-related regional volume loss is apparent and widespread in nondemented individuals, mild cognitive impairment is associated with a unique pattern of structural vulnerability reflected in differential volume loss in specific regions. Early identification of patterns of abnormality is of fundamental importance for detecting disease onset and tracking progression.
Fast, multi-frequency and quantitative nanomechanical mapping of live cells using the atomic force microscope (2015)

A longstanding goal in cellular mechanobiology has been to link dynamic biomolecular processes underpinning disease or morphogenesis to spatio-temporal changes in nanoscale mechanical properties such as viscoelasticity, surface tension, and adhesion. This requires the development of quantitative mechanical microscopy methods with high spatio-temporal resolution within a single cell. The Atomic Force Microscope (AFM) can map the heterogeneous mechanical properties of cells with high spatial resolution, however, the image acquisition time is 1-2 orders of magnitude longer than that required to study dynamic cellular processes. We present a technique that allows commercial AFM systems to map quantitatively the dynamically changing viscoelastic properties of live eukaryotic cells at widely separated frequencies over large areas (several 10's of microns) with spatial resolution equal to amplitude-modulation (AM-AFM) and with image acquisition times (tens of seconds) approaching those of speckle fluorescence methods. This represents a ~20 fold improvement in nanomechanical imaging throughput compared to AM-AFM and is fully compatible with emerging high speed AFM systems. This method is used to study the spatio-temporal mechanical response of MDA-MB-231 breast carcinoma cells to the inhibition of Syk protein tyrosine kinase giving insight into the signaling pathways by which Syk negatively regulates motility of highly invasive cancer cells.
Infrared and Computational Studies of the Adsorption of Methanol and Ethanol on Single-Walled Carbon Nanotubes (2007)

The adsorption of methanol and ethanol on room-temperature single-walled carbon nanotubes (SWCNTs) has been investigated using Fourier transform infrared (FTIR) spectroscopy and two-level ONIOM calculations. Whereas methanol does not adsorb onto SWCNTs at room temperature, ethanol does adsorb molecularly under these conditions. The IR data show that the adsorbed ethanol is in an environment quite similar to that of liquid ethanol. Comparison to studies of clusters of ethanol indicates that adsorbed ethanol molecules likely form cyclic clusters of four or more molecules, and ONIOM calculations suggest that these clusters can form inside the largest-diameter nanotubes in the sample. The nature of ethanol adsorption has implications for previously reported measurements of changes in the electrical properties of SWCNTs upon ethanol adsorption.
Uniform stability of a class of large-scale parallel server networks (2019)

In this paper we show that a large class of parallel server networks, with $\sqrt{n}$ safety staffing, and no abandonment, in the Halfin-Whitt regime are exponentially ergodic and their invariant probability distributions are tight, uniformly over all stationary Markov controls. This class consists of all networks of tree topology with a single non-leaf server pool, such as the 'N' and 'M' models, as well as networks of any tree topology with class-dependent service rates. 
We first define a parameter which characterizes the spare capacity (safety staffing) of the network. If the spare capacity parameter is negative, we show that the controlled diffusion is transient under any stationary Markov control, and that it cannot be positive recurrent when this parameter is zero. Then we show that the limiting diffusion is uniformly exponentially ergodic over all stationary Markov controls if this parameter is positive. 
As well known, joint work conservation, that is, keeping all servers busy unless all queues are empty, cannot be always enforced in multiclass multi-pool networks, and as a result the diffusion limit and the prelimit do not match on the entire state space. For this reason, we introduce the concept of work conserving policies, which are defined as policies that minimize the number of idle servers at all times. We show that, provided the spare capacity parameter is positive, the diffusion-scaled processes are geometrically ergodic and the invariant distributions are tight, uniformly over all system-wide work conserving policies. In addition, when the spare capacity is negative we show that the diffusion-scaled processes are transient under any stationary Markov control, and when it is zero, they cannot be positive recurrent. We use a unified approach in which the same Lyapunov function is used in the study of the prelimit and diffusion limit.
Concluding Remarks (2023)

This conclusion presents some closing thoughts on the concepts covered in the preceding chapters of this book. The book explains the development of theoretical frameworks, experimental fabrication techniques, high-resolution measurements, and excellent performance of energy storage and conversion materials, including lithium-ion-based batteries, supercapacitors, solar cells, and fuel cells. It explains the physical and electronic properties of Na-intercalation compounds by first-principles calculations, such as geometric structure, band structure, density of states, and spatial charge distribution. The book argues that that the LiMnO2 compound has fascinating electronic and magnetic properties based on Vienna Ab initio Simulation Package analysis results. It presents the idea of producing next-generation dye-sensitized solar cells because the novel and optimal classical DSSC materials utilized to improve the performance of DSSCs under ambient lighting.
Supplementary Table 1 from Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor (2023)

Supplementary Table 1 from Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor
Microwave and DC anisotropy fields of exchange-coupled CoFe/PtMn/CoFe trilayers (2006)

In this paper, the authors examined the ferromagnetic resonance (FMR) characteristics of CoFe/PtMn/CoFe trilayer thin films to determine mechanisms behind the intermediate drop in linewidth observed, and investigate the exchange bias fields (Hex) at DC versus at X-band (9.5 GHz). Results showed that the FMR linewidth did not drop monotonically with the increase of FM thickness in the exchange coupled trilayers. This non-monotonic FMR linewidth drop could be utilized in integrated microwave magnetic materials for RF and microwave devices.
Beyond the Tsunami: Developing the Infrastructure to Deal with Life Sciences Data (2014)

Chapter from: <strong>The Fourth Paradigm: Data-Intensive Scientific Discovery</strong> Presenting the first broad look at the rapidly emerging field of data-intensive science. 2009
Demonstration of three-port grating phase relations (2006)

We experimentally demonstrate the phase relations of three-port gratings by investigating three-port coupled Fabry-Perot cavities. Two different gratings that have the same first-order diffraction efficiency but differ substantially in their second-order diffraction efficiency have been designed and manufactured. Using the gratings as couplers to Fabry-Perot cavities, we could validate the results of an earlier theoretical description of the phases at a three-port grating [Opt. Lett. 30, 1183 (2005)].
Triplet energy harvesting by lanthanides in conjugated polymers (2002)

We report the design, synthesis, and spectroscopic characterization of polyphenylene-type polymers that can be used to sensitize europium complexes. Although benzophenone is widely studied and characterized, polybenzophenones have not been widely used in photophysical studies. The properties of poly(4'-methyl-2,4-benzophenone) (<b>MB</b>), poly(4'-methyl-2,5-benzophenone) (<b>PB</b>) and poly[2,2'-bipyridine-5,5'-diyl(2,5-didecoxy-1,4-phenylene)] (<b>PBP</b>) are described in this paper. All three polymers have backbones that are similar to polyphenylene. <b>PBP</b> has a bipyridine unit that alternates with a phenyl ring. Benzophenone rings are polymerized with para or meta linkages in <b>PB</b> and <b>MB</b>, respectively. All three polymers have similar emission maxima at 430 nm, but <b>PBP</b> has a higher quantum efficiency of emission. The polymers studied in this paper proved to be of lower energy than what is needed to sensitize many europium complexes. In almost all of the lanthanide complexes the ligands played a major role in the emission properties. This was elaborated in studies done previously. Europium chelates of the two different ligands: di(2-thienoyl)methane (<b>DTM</b>) and di(2-naphthoyl)methane (<b>DNM</b>) proved to be of comparable energies with the polymers studied. Results showed that energy transfer did occur between the polymers and the europium chelates, but the energy transfer was not 100% because residual emission from the polymers was detected.
Unequal-thickness billet optimization in transitional region during isothermal local loading forming of Ti-alloy rib-web component using response surface method (2017)

Avoiding the folding defect and improving the die filling capability in the transitional region are desired in isothermal local loading forming of a large-scale Ti-alloy rib-web component (LTRC). To achieve a high-precision LTRC, the folding evolution and die filling process in the transitional region were investigated by 3D finite element simulation and experiment using an equal-thickness billet (ETB). It is found that the initial volume distribution in the second-loading region can greatly affect the amount of material transferred into the first-loading region during the second-loading step, and thus lead to the folding defect. Besides, an improper initial volume distribution results in non-concurrent die filling in the cavities of ribs after the second-loading step, and then causes die underfilling. To this end, an unequal-thickness billet (UTB) was employed with the initial volume distribution optimized by the response surface method (RSM). For a certain eigenstructure, the critical value of the percentage of transferred material determined by the ETB was taken as a constraint condition for avoiding the folding defect in the UTB optimization process, and the die underfilling rate was considered as the optimization objective. Then, based on the RSM models of the percentage of transferred material and the die underfilling rate, non-folding parameter combinations and optimum die filling were achieved. Lastly, an optimized UTB was obtained and verified by the simulation and experiment.
Dyspepsia: incidence of a non-ulcer disease in a controlled trial of ranitidine in general practice. (1986)

Patients who presented to their family doctors with previously uninvestigated dyspepsia of at least two weeks' duration were recruited into a placebo controlled trial of treatment with ranitidine (150 mg twice daily) for six weeks. All patients were examined by endoscopy before treatment, and for those with macroscopical abnormalities the examination was repeated after treatment. Of the 604 patients recruited, 559 had endoscopy, of whom 171 (30%) had no apparent abnormality. Of the 388 patients remaining, one third had two or more lesions. The high incidence of underlying disease was coupled with low accuracy in unaided clinical diagnosis. After endoscopy 496 patients with persistent symptoms (median duration six to eight weeks) were randomly allocated to treatment and then reviewed every two weeks. Complete remission of symptoms occurred in 76% of patients who were taking ranitidine and in 55% who were taking placebo (p less than 0.000004). Of those with non-ulcer dyspepsia, significantly more became symptom free taking ranitidine compared with placebo (p less than 0.002). Ranitidine healed most duodenal ulcers (80%) and gastric ulcers (90%) within four weeks. Tolerance to ranitidine was good, and the incidence of complaints was similar on placebo.
Phenolic nature, occurrence and polymerization degree as marker of environmental adaptation in the edible halophyte Mesembryanthemum edule (2011)

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