gebhart/patrepeval huggingface dataset:
Decellularized extra cellular matrix derived tissue papers: creating simple and complex, tissue-specific constructs through integration of 2D casting and 3D-printing technologies (2016)

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ChemInform Abstract: REACTIONS OF BISHALOMETHYLARENES WITH SUPEROXIDE (1978)

Abstract Aus den Bis‐halogenmethylaromaten (I), (V) und (VIII) entstehen bei Reaktion mit K‐superoxid die Dioxene (II), (VI) und (IX).
FALCON: Feedback Adaptive Loop for Content-Based Retrieval (2000)

Several methods currently exist that can perform relatively simple queries driven by relevance feedback on large multimedia databases.
Predicting query reformulation type from user behavior (2013)

This paper proposes a method to discover how a user's search intent changes using his/her behavior during a Web search. A Web search user has a particular search intent and formulates search queries according to that intent. It is, however, a difficult task for the user to formulate a optimal query, a single query able to find documents which completely satisfy his/her information need, by himself. After issuing the initial query, the user usually examines the search results, and modifies his/her initial query. The subsequent queries may be a query of Specialization type, Parallel Move type and so on. By recording these subsequent queries and the corresponding user behavior (including eye-gazing behavior), the present work tries to find the relationship between the user's query reformulation and user's behavior. The proposed method constructs a SVM classifier from the behavior log data obtained from the search and browsing processes. Our experimental results show that the proposed method can classify the next query reformulation into five categories using only the current search behavior data with about 41 % accuracy, greater than the baseline methods. We also analyze which and to what extent the user's behavior data is useful for predicting query reformulations.
Age-dependent Prevalence of Vascular Disease-associated Polymorphisms among 2689 Volunteer Blood Donors (2001)

These data suggest that Pl(A2) carriers, especially those who are ACE DD, are statistically less prevalent among older healthy blood donors compared with their younger counterparts. These observations suggest an important, deleterious, time-dependent impact of the Pl(A2) allele, as well as the ACE DD/Pl(A2) allelic combination, on overall health and longevity.
The development of transcatheter heart valves: Opportunities and challenges (2009)

The medical device industry has undertaken the development of transcatheter heart valves (TCV). These devices are tissue heart valves that can be delivered without open heart surgery and are intended to complement the portfolio of current and future surgical valve products. Several companies have developed novel product designs. Some transcatheter valves are currently available for the aortic and pulmonic positions via European CE mark, and are in clinical trials throughout the United States. Although substantial progress has been made, the biomedical engineering community can provide tremendous value to both patients and clinicians through continued innovation in product design, development of new tools for product testing, and through novel means of improving the ease and accuracy of device deployment. In addition, smaller crimp profiles may be feasible as technology and design advancements are made. A smaller TCV could then target a larger patient population, and allow easier delivery during procedures for patients with tortuous and severely diseased anatomies.
Major psychological factors affecting consumer’s acceptance of food additives (2015)

Purpose – The purpose of this paper is to verify the validity of a causal model that was made to predict the consumer’s acceptance of food additives. Design/methodology/approach – A new emotional model in which cognitive factors influence emotional factors from the bottom-up was made and the validity of the model was tested. A social survey was conducted in Tokyo, Japan, among 120 female undergraduate students. Findings – The results showed that the new emotional model had a higher validity than the conventional emotional model, in which emotional factors influence cognitive factors. Research limitations/implications – The reliability and validity of the present models should be reconfirmed with a sample of more than 200 subjects in the future. The sample comprised only Japanese female undergraduate students and additional studies be conducted with diverse samples to ensure that the proposed model is valid and reliable across multiple settings. Future studies should verify whether the use of other topics would produce the same results. Practical implications – As it is often difficult to directly affect consumer’s emotions by providing information and education for only a short period of time, it may be advisable to try to change consumer’s cognitions about the perceived risks and benefits through information and education instead. Social implications – The greater significance of the current study is the suggestion that the influence of perceptions on emotions should also be considered when evaluating consumer’s acceptance. Originality/value – This study showed that the influence of cognitive factors, such as perceived risk and perceived benefit, is also effective in an emotional model. This importantly suggests that consumer’s emotions like anxiety and anger can be changed by altering consumer’s cognitions or perceptions.
Polarization Modulation Instability in All-Normal Dispersion Microstructured Optical Fibers with sub-ns Pumping (2019)

The advent of microstructured optical fiber (MOF) technology gave a significant boost to research in nonlinear optics. MOFs have the advantage of high nonlinearity and designable dispersion, which makes this type of fiber an excellent platform for efficient generation of nonlinear effects. In the last years, MOFs exhibiting normal dispersion at any guiding wavelength (ANDi fibers) aroused the interest because of the possibility of using them for the generation of coherent and recompressible supercontinuum (SC) light. In this contribution, we present our recent results regarding the generation of the polarization modulation instability (PMI) effect in ANDi MOFs in the quasi-CW pump regime at 1064 nm. The experimental observation of this nonlinear effect is reported, along with the theoretical analysis of it.
Production and characterization of a monoclonal antibody against the seed lectin of the Dolichos biflorus plant. (1981)

Spleen cells from mice immunized with the Dolichos biflorus seed lectin were fused with cells from the mouse myeloma Sp2/O-Ag14 cell line to form hybridomas. Those hybridomas producing antibodies against the seed lectin were cloned at least four times and the monoclonal antibodies from clone C11/64-56.28 were characterized and found to be specific for Subunit I of the lectin; they do not react with the structurally similar Subunit II. In previous studies, we have shown that although these two subunits appear to differ only at their COOH-terminal ends, only Subunit I has carbohydrate binding activity. Using a solid phase enzyme immunoassay, the antigenic determinant fr the monoclonal antibody was found to be located on the COOH-terminal cyanogen bromide fragment of this subunit. The monoclonal antibody inhibits the ability of the lectin to agglutinate erythrocytes and N-acetyl-D-galactosamine, the specific hapten for the lectin, inhibits the ability of the antibody to combine with the lectin. These results suggest that the monoclonal antibody recognizes a determinant that is located either at or near the active site of the lectin or that is conformationally interdependent with the active site.
Specialty optical fibers for advanced sensing applications (2023)

Optical fiber technology has changed the world by enabling extraordinary growth in world-wide communications and sensing. The rapid development and wide deployment of optical fiber sensors are driven by their excellent sensing performance with outstanding flexibility, functionality, and versatility. Notably, the research on specialty optical fibers is playing a critical role in enabling and proliferating the optical fiber sensing applications. This paper overviews recent developments in specialty optical fibers and their sensing applications. The specialty optical fibers are reviewed based on their innovations in special structures, special materials, and technologies to realize lab in/on a fiber. An overview of sensing applications in various fields is presented. The prospects and emerging research areas of specialty optical fibers are also discussed.
Web Platform for Collaboration and Medical Case Documentation (2012)

Creating medical applications of additive manufacturing (AM) is a complex multidisciplinary process. There is a need to examine this process in more detail to understand it better, which is crucial for its further development. The objective of this study was to investigate the design and production process of medical applications of AM and to develop an online platform for the documentation and planning of medical application of AM cases. The study was motivated by the fact that the medical applications of AM field is lacking a comprehensive classification standard and a process model which depicts the design and manufacturing process. A web platform would enable professionals to collaborate meaningfully on this complex and multidisciplinary subject. The online platform was developed by using Drupal content management system and PHP programming. The result was a dynamic web platform where users can view and document case studies using the designed matrix framework and communicate and collaborate with other professionals in the field.
Behaviour change and incentive modelling for water saving: first results from the SmartH2O project (2016)

Stimulating users to save water is a challenge and an opportunity for water demand management. Existing ICT-based systems for behavioural change often do not consider the underlying behavioural determinants in a systematic way. This paper discusses the design of the behavioural change and incentive model for the SmartH2O system, combining smart meter data with consumption visualisation and gamified incentive mechanisms to stimulate water saving. We show how the design of such a system can be related to a holistic behavioural change model and how this systematic mapping can inform the design of an integrated incentive model combining different incentive types (virtual, physical, social). The model is implemented in the SmartH2O system, and deployed in two pilots. We present the preliminary results for the Swiss pilot. Even though the interim status and sample size do not allow for final conclusions, first results indicate reduced water consumption, positive user feedback and suitability of the designed incentive model.
The latest ocular allergy treatments worth watching (2017)

Progress of ocular allergy treatment in 2017 starts with the fact that this is a mature therapeutic space, with a range of existing choices for clinicians and patients. Progression in therapies from artificial tears to antihistamines and mast cell stabilizers to topical steroids provides a suitable choice for most patients with ocular allergies.
Melatonin effect on hypoxia inducible factor-1a and clinical response in patients with oral squamous cell carcinoma receiving neoadjuvant chemotherapy: A randomized controlled trial (2021)

Our study showed that melatonin administered at 20 mg/day could reduce the expression of HIF-1α and residual tumor percentage, but did not affect the clinical response in OSCC patients.
DESIGN AND CALIBRATION OF AN INSTRUMENTED FEMORAL PROSTHESIS FOR MEASUREMENTS OF HIP JOINT FORCES INTRA-OPERATIVELY (2018)

IntroductionDislocation continues to be a common complication of total hip arthroplasty (THA). Many factors affect the prevalence of dislocation after THA, including soft tissue laxity, surgical approach, component position, patient factors, and component design [1]. Achieving proper intraoperative soft tissue tension is one of the surgical goals to reduce the risk of the dislocation. However, reports of the intraoperative soft tissue tension measurements have not been enough yet. One way to quantify the intraoperative soft tissue tension is to measure joint forces using an instrumented prosthesis. Hence, we have developed a sensor-instrumented modular femoral head of THA to measure the soft-tissue tension intraoperatively. The goal of this study was to design and calibrate the sensor.Materials and MethodsThe sensor-instrumented modular femoral head that we developed was made of polycarbonate with four linear strain gauges (BTM-1C, Tokyo Sokki Kenkyujo Co., Ltd., JP). To fabricate the sensor, four penetra...
Heart rate and mortality in myocardial infarction: incremental or bimodal correlation? (2022)

Abstract Introduction Risk prediction scores adopted in acute coronary syndromes use incremental models to estimate mortality for heart rate (HR) above 60 bpm. Nonetheless, a non-linear, bimodal relationship, with higher event rates at low or high HR, has been described, potentially hampering risk prediction accuracy. Purpose Our aim was to assess the prognostic impact of bradycardia, defined as admission HR &amp;lt;50 bpm, in myocardial infarction (MI) among patients enrolled in a large nationwide registry. Methods Data of patients enrolled between 1999 and 2021 stratified by admission HR were retrospectively analysed. The primary endpoint was in-hospital mortality. The secondary endpoint was a composite of death, cerebrovascular event, and reinfarction. Associations between HR and outcomes were assessed at univariate and multivariable logistic regression analyses, then verified after sequential propensity-score matchings among HR groups. Results 51001 patients (median age 66 years, IQR 56–76) were included. Crude estimates showed a bimodal distribution of primary and secondary endpoints with peaks at low and high HR. Association of HR &amp;lt;50 bpm with mortality was recognised only at primary multivariable logistic regression analysis (OR 1.49; 95% CI 1.01–2.13 p=0.038) but not at multiple sensitivity analyses after exclusion of patients on negative chronotropic therapy. Three sequential propensity-score matching were performed among patients with HR &amp;lt;50 bpm at admission and those with HR 50–75 bpm, HR 76–100 bpm and HR &amp;gt;100 bpm at admission, identifying 1159, 1159 and 1158 matched pairs, respectively. After propensity-score matching, rates of primary and secondary endpoints equalled among groups with HR &amp;lt;100 bpm. Conclusions Bradycardia (HR &amp;lt;50 bpm) at admission in patients with MI identified a group with higher crude rate of adverse events. Nonetheless, the signal supporting an independent association between bradycardia at admission and short-term mortality is weak and was not confirmed after correction for relevant baseline differences by propensity score matching. These findings support the hypothesis that lower HR might not be causative for the worse outcomes, but rather serves as a marker of underlying morbidity. Funding Acknowledgement Type of funding sources: Other. Main funding source(s): The AMIS Plus registry is funded by unrestricted grants from the Swiss Heart Foundation and from Abbot AG, Amgen AG, AstraZeneca AG, Bayer (Schweiz) AG, Biotronik AG, Boston Scientific AG, B. Braun Medical AG, Daiichi-Sankyo/Lilly AG, Cordis Cardinal Health GmbH, Medtronic AG, Novartis Pharma Schweiz AG, Sanofi-Aventis (Schweiz) AG, SIS Medical AG, Terumo AG, Vascular Medical GmbH, all in Switzerland, and the Swiss Working Group for Interventional Cardiology. The sponsors did not play any role in the design, data collection, analysis, or interpretation of data.
X-ray Structures of the Three Lactococcus lactis Dihydroxyacetone Kinase Subunits and of a Transient Intersubunit Complex (2008)

Bacterial dihydroxyacetone (Dha) kinases do not exchange the ADP for ATP but utilize a subunit of the phosphoenolpyruvate carbohydrate phosphotransferase system for in situ rephosphorylation of a permanently bound ADP-cofactor. Here we report the 2.1-angstroms crystal structure of the transient complex between the phosphotransferase subunit DhaM of the phosphotransferase system and the nucleotide binding subunit DhaL of the Dha kinase of Lactococcus lactis, the 1.1-angstroms structure of the free DhaM dimer, and the 2.5-angstroms structure of the Dha-binding DhaK subunit. Conserved salt bridges and an edge-to-plane stacking contact between two tyrosines serve to orient DhaL relative to the DhaM dimer. The distance between the imidazole Nepsilon2 of the DhaM His-10 and the beta-phosphate oxygen of ADP, between which the gamma-phosphate is transferred, is 4.9 angstroms. An invariant arginine, which is essential for activity, is appropriately positioned to stabilize the gamma-phosphate in the transition state. The (betaalpha)4alpha fold of DhaM occurs a second time as a subfold in the DhaK subunit. By docking DhaL-ADP to this subfold, the nucleotide bound to DhaL and the C1-hydroxyl of Dha bound to DhaK are positioned for in-line transfer of phosphate.
Then Melancholy, Now Depression (2007)

The authors identify two Rembrandt etchings of 1642, Saint Jerome in a Dark Chamber and A Scholar at a Table by Candlelight, as self-portraits. Considered with biographical data, the prints suggest that Rembrandt suffered from a bipolar personality disorder, manifest in exuberance and lavish spending in the 1630s, and then, after the death of the artist's wife, in clinical depression in the early 1640s. Depression is depicted in the prints by their dark ambiance, and the figure's pose is traditional in art to represent melancholia, one of the four classical humors conventionally ascribed to artistic genius. In addition, the authors identify as a portrait of his wife the object at which the "scholar" is looking. Although the panel is turned away from the viewer of the etching, its size, shape, and material suggest that it is a painting that survives in Kassel, Germany.
Long-Term Formaldehyde Emission Potential from UF- and NAF-Bonded Particleboards (2020)

As a result of the dominance of urea formaldehyde (UF)-bonded particleboard, it seemed worthwhile to examine formaldehyde emissions years after production. A California Air Resources Board (CARB) phase II-compliant commercial particleboard produced with a UF resin adhesive was compared to a no-added formaldehyde (NAF)-particleboard produced with Soyad™ adhesive resin for formaldehyde emissions during exposure to elevated humidity and temperature conditions after being in a room at 21 ± 1.9 °C, 50 ± 3.3% relative humidity for 3.5 years. A modified version of EN 717-3 was used to collect formaldehyde emissions under typical along with higher temperature and humidity conditions. The formaldehyde emissions from the commercial particleboard panel bonded with a UF adhesive even after the 3.5 years of exposure greatly increased only during exposure of the panels to elevated heat and humidity compared to typical testing conditions. The amounts were the same as those with the previous shorter-term study. In contrast, formaldehyde emissions from the NAF-bonded particleboard were not as susceptible (in absolute terms) to increases in temperature and relative humidity conditions.
Molecularly imprinted nanoparticles-based assay (MINA) – detection of leukotrienes and insulin (2020)

A novel molecularly imprinted polymer nanoparticle-based assay (MINA) performed in magnetic microplates was developed as an improved high-quality alternative to existing antibody-based immunoassays. MINA is a generic technology that can be adapted for biomarker detection in biological samples. Herein, we demonstrate the applicability of the MINA assay for the detection of leukotrienes and insulin in biological samples. MINA, used in a competition format, has allowed the detection of LTE4 in urine in a concentration range from 0.45 to 364 pM, with a LOD of 0.73 pM. MINA, used in a competition format, has allowed the detection of insulin in plasma in a concentration range from 25 to 2500 pM, with a LOD of 27 pM. This assay has shown comparable performance for LTE4 and insulin detection to existing chromatographic techniques (LC-MS/MS) and immunoassays in clinically relevant concentrations. The main advantages of this assay are the efficient and low cost fabrication, preparation of synthetic binders without the use of animals, and fewer steps used in the assay protocol as compared to traditional immunoassays.
Expression of aquaporin-1 in endometrial blood vessels in menorrhagia (2007)

Aquaporin-1 (AQP1) is a water channel protein expressed in vascular endothelia and involved in impaired angiogenesis in tumors. Since angiogenesis is an essential component of the regeneration of the endometrium, we sought to analyze the expression of AQP1 in endometrial blood vessels in normal cyclic endometrium as well as in endometrial biopsies of menorrhagia patients. Endometrial biopsies from 16 patients with menorrhagia and 21 healthy fertile women were used for immunohistochemistry assessment of AQP1-stained endothelial structures. RT-PCR was used to confirm the presence of AQP1 mRNA. We detected the expression of AQP1 solely in endometrial blood vessels in the control group, as well as in menorrhagic endometrium. There was no difference between proliferative and secretory endometrium. Furthermore, we observed that the vascular expression of AQP1 in endometrial blood vessels in the menorrhagia group was significantly lower than in controls (p=0.002). There was also a significantly lower number of stained vessels per unit area in the menorrhagia group than in the controls (p=0.006). Thus, the deregulation of aquaporin-1 in menorrhagia may be involved in abnormal endometrial vascular growth and permeability.
Catalytic Coupling of Haloolefins with Anilides (2005)

A strategy in which C-H activation reactions promoted by Pd(II) have been combined with beta-heteroatom elimination to create a catalytic cycle achieving the arylation of haloacrylates is reported. The catalytic cycle can be subdivided into four parts: (1) C-H activation; (2) the functionalization step, migratory insertion of the olefin into a metal-carbon bond; (3) beta-heteroatom elimination; and (4) exchange of metal halide (if X = halogen) for a less coordinating anion. In this catalytic cycle, the oxidation state of the metal does not change, and an oxidant is not required. The method is more functional group tolerant compared with the existing alkene-arene coupling methods based on electrophilic C-H activation.
Pyogenic Spondylitis (1978)

During the period 1972-1974 10 patients suffering from pyogenic spondylitis have been treated at the Central Hospital of Middle Finland. Three of the patients had become acutely ill with septic fever and back pain. In the remaining cases the onset of the disease was insidious. Fever, weight loss and fatigue were the general symptoms. Percussion revealed local tenderness at the site of infection in all patients. Two patients showed neurological signs. The ESR was elevated in all cases and alkaline phosphatase was elevated in six patients. Blood culture was positive in those three patients who had become acutely ill. Narrowing of the intervertebral space was observed in all patients. Scanning with Tc99 was performed in nine patients, seven of whom were at an early stage of the disease; a significant uptake was recorded in five of these cases. The average interval between the onset of symptoms and the diagnosis was 3 months, range 1 to 5 months. The treatment consisted of bed rest and antibiotics. All the patients recovered and became symptom-free.