gebhart/patrepeval huggingface dataset:
ATP Release from the Isolated Perfused Guinea Pig Heart in Response to Increased Flow (1996)

The Langendorff heart preparation was used to investigate the release of ATP from the guinea pig heart in response to increased coronary flow. The lucifer-in-luciferase firefly technique was used to determine levels of ATP in the perfusate. During periods of increased flow, ATP release was rapidly and significantly increased by at least tenfold the basal release. The pressure/flow ratio was reduced in increased-flow conditions suggesting that coronary vasodilatation had occurred. It is concluded that ATP release from the guinea pig heart is increased under raised-flow conditions. It is suggested that this ATP release induces coronary vasodilatation.
Longitudinal Changes in Self-Reported Walking Ability in Multiple Sclerosis (2015)

This novel finding of frequent fluctuations in self-reported walking ability is new and requires further investigation.
Content-oriented integration in hypermedia systems (1996)

In this paper, we present the concept and the general framework of a new integration model for hypermedia systems, the content-oriented integration. Content-oriented integration provides an integrated navigational environment that consists of both conceptual-based navigation and
Catalytic Enantioselective 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with α,β-Unsaturated Aldehydes (2010)

Catalytic Enantioselective 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with α,β-Unsaturated Aldehydes
In-Situ Interferometry Studies of the Drying and Swelling Kinetics of an Ultrathin Poly(N-isopropylacrylamide) Gel Film below and above Its Volume Phase Transition Temperature (1996)

The temperature influence on the drying and swelling kinetics of ultrathin poly(N-isopropylacrylamide) gel film were studied by in-situ interferometry. The drying rate is greatly dependent on temperature. When T ≲ 31 °C, the original gel film was swollen and contained more than 99% of water before drying. Our results showed that the initial drying rate was a constant. However, it became faster and faster toward the end of the drying. On the other hand, when T ≳ 32 °C, the gel film was in the collapsed state, but still contained ∼70% of water, before drying. Three distinct drying processes were observed, namely, a very fast initial shrinking, a slow transition period, and a normal drying process similar to that of the gel film when T ≲ 31 °C. As for the swelling process, it can be better described by the first-order kinetics developed by Li and Tanaka. The cooperative diffusion coefficient and the ratio of the shear modulus to the longitudinal modulus were determined from a least-squares fitting of the swelling experimental data according to the swelling equation for a large disk. A critical slowing down of the gel swelling for the thin film was observed in the range of 33−35 °C.
Interventionelle Therapieverfahren zur Behandlung von Nahtinsuffizienzen nach Adipositas Eingriffen (2017)

Eine Nahtleckage stellt bei bariatrischen Operationen eine gefürchtete Komplikation dar. Als Behandlungsoption rückt zunehmend die endoluminale Vakuumtherapie/Stenteinlage in den Vordergrund.
Characterization and Optimization of Biosynthesis of Bioactive Secondary Metabolites Produced by Streptomyces sp. 8812 (2016)

The nutritional requirements and environmental conditions for a submerged culture of Streptomyces sp. 8812 were determined. Batch and fed-batch Streptomyces sp. 8812 fermentations were conducted to obtain high activity of secondary metabolites. In the study several factors were examined for their influence on the biosynthesis of the active metabolites-7-hydroxy-6-oxo-2,3,4,6-tetrahydroisoquinoline-3-carboxy acid (C10H9NO4) and N-acetyl-3,4-dihydroxy-L-phenylalanine (C11H13NO5): changes in medium composition, pH of production medium, various growth phases of seed culture, amino acid supplementation and addition of anion exchange resin to the submerged culture. Biological activities of secondary metabolites were examined with the use of DD-carboxypeptidase 64-575 and horseradish peroxidase. Streptomyces sp. 8812 mycelium was evaluated under fluorescent microscopy and respiratory activity of the strain was analyzed. Moreover, the enzymatic profiles of the strain with the use of Api ZYM test were analyzed and genetic analysis made. Phylogenetic analysis of Streptomyces sp. 8812 revealed that its closest relative is Streptomyces capoamus JCM 4734 (98%), whereas sequence analysis for 16S rRNA gene using NCBI BLAST algorithm showed 100% homology between these two strains. Biosynthetic processes, mycelium growth and enzyme inhibitory activities of these two strains were also compared.
Gemcitabine as frontline treatment for cutaneous T‐cell lymphoma (2005)

The results of the current Phase II study demonstrate the activity of gemcitabine as a single agent in untreated CTCL patients. Further studies using gemcitabine in combination, either contemporary or sequentially, with other drugs in patients with advanced stage, untreated CTCL are needed.
Alterations in the aqueous humor proteome in patients with a glaucoma shunt device. (2011)

The presence of these proteins in the aqueous humor suggests that glaucoma shunt device causes either a breach in blood-aqueous barrier or chronic trauma, increasing influx of oxidative, apoptotic and inflammatory proteins that could potentially cause corneal endothelial damage.
Characterizing the biological role of lactoferrin in early life using a lactoferrin receptor knockout mouse model (38.7) (2014)

The iron‐binding glycoprotein lactoferrin (Lf) is highly abundant in human milk. Lf is hypothesized to exert various effector functions within the GI tract of the infant including maturation of the intestinal epithelium and immune system. A lactoferrin receptor (LfR) has been isolated from human fetal and mammalian small intestine (e.g., mouse and pig), and has been shown to facilitate cellular uptake and intracellular trafficking of Lf. Despite strong evidence indicating that the LfR orchestrates multiple biological activities ascribed to Lf, there is currently no in vivo evidence attributing the regulatory mechanisms and tissue‐specific functions of Lf to the LfR. Our laboratory has developed the first LfR knockout mouse model to investigate the physiological role of Lf and the LfR during early life. Global gene and protein ablation was confirmed by PCR and Western blot analysis of multiple tissues. Protein expression analysis showed the LfR is highly expressed within mucosal tissues (e.g., small intestine and lungs) and at site‐specific regions of tissues directing global metabolism (e.g., liver and kidneys), suggesting that the LfR likely serves a role in host defense. The intestinal mucosa of the infant is a primary site for maternally derived protective factors. The LfR may exert intrinsic activity as a component of the mucosal immune milieu and also direct the activities of milk‐derived Lf.
Selection of Samples for Calibration in Near-Infrared Spectroscopy. Part II: Selection Based on Spectral Measurements (1990)

Two strategies for selection of samples based on spectral measurements on a large set of samples are tested and compared. A method based on cluster analysis appears to be the best. The same prediction results achieved with the whole calibration set of 114 samples were obtained with only 20 samples selected by this algorithm.
Homologous recombination and the repair of DNA double-strand breaks (2018)

Homologous recombination enables the cell to access and copy intact DNA sequence information in <i>trans</i>, particularly to repair DNA damage affecting both strands of the double helix. Here, we discuss the DNA transactions and enzymatic activities required for this elegantly orchestrated process in the context of the repair of DNA double-strand breaks in somatic cells. This includes homology search, DNA strand invasion, repair DNA synthesis, and restoration of intact chromosomes. Aspects of DNA topology affecting individual steps are highlighted. Overall, recombination is a dynamic pathway with multiple metastable and reversible intermediates designed to achieve DNA repair with high fidelity.
Power allocation in Uplink Multiband Satellite System with Nonlinearity-Aware Receiver (2021)

In this paper, we address power allocation for an uplink multiband single-beam satellite system taking into account on-board nonlinearities. These nonlinearities are generated by the high power amplifier. Based on the closed-form expression of the capacity associated with the optimal receiver exploiting the structure of the nonlinear effects, three power allocations are studied: maximization of the sum-rate, maximization of the minimum of the rates, and minimization of the sum of the powers. The related optimization problems boil down nonconvex problems that can be cast and solved by using signomial programming. We propose practical and scalable algorithms for fixing these power allocation problems.
Minimally Invasive Ulnar Nerve Decompression for Cubital Tunnel Syndrome (2009)

Objective: The purpose of this study is to present the efficacy of the surgical technique using a minimal skin incision for the treatment of cubital tunnel syndrome. Ulnar nerve entrapment at the elbow is the second most common compression neuropathy of the upper extremity. Surgical treatment of conventional simple decompression of ulnar nerve is considered to be relatively safe and reliable. However, this surgical technique is needed a relatively long incision and often can result in significant postoperative scarring and delay in return to work. Methods: Ten patients with cubital tunnel syndrome underwent simple decompression using a 2 cm or less skin incision. According to Dellon’s criteria, one elbow was classified as grade 1, four as grade 2, and five as grade 3. Preoperative electrodiagnostic studies were performed on all patients and 6 of them were rechecked postoperatively. Results: Preoperative motor conduction velocity (MCV) within the segment was 35.5±16.2 m/s and decreased than the result of MCV in the below the elbow-wrist segment (59.3±5.9 m/s, p< 0.05). Postoperative results of MCV were improved in all patients from 37.1±13.2 m/s to 51.9±8.9 m/s (p<0.05). After an average follow-up of 5.9±5.0 months, all patients were reported to be in good or excellent condition. Conclusion: We could observe an enough distance of the ulnar nerve from proximal to distal area without difficulty using manual retraction. Simple decompression through a small skin incision can be recommended for the treatment of cubital tunnel syndrome, if the indication is appropriate. (J Kor Neurotraumatol Soc 2009;5:16-21)
Structural basis for activation of the complement system by component C4 cleavage (2012)

An essential aspect of innate immunity is recognition of molecular patterns on the surface of pathogens or altered self through the lectin and classical pathways, two of the three well-established activation pathways of the complement system. This recognition causes activation of the MASP-2 or the C1s serine proteases followed by cleavage of the protein C4. Here we present the crystal structures of the 203-kDa human C4 and the 245-kDa C4·MASP-2 substrate·enzyme complex. When C4 binds to MASP-2, substantial conformational changes in C4 are induced, and its scissile bond region becomes ordered and inserted into the protease catalytic site in a manner canonical to serine proteases. In MASP-2, an exosite located within the CCP domains recognizes the C4 C345C domain 60 Å from the scissile bond. Mutations in C4 and MASP-2 residues at the C345C-CCP interface inhibit the intermolecular interaction and C4 cleavage. The possible assembly of the huge in vivo enzyme-substrate complex consisting of glycan-bound mannan-binding lectin, MASP-2, and C4 is discussed. Our own and prior functional data suggest that C1s in the classical pathway of complement activated by, e.g., antigen-antibody complexes, also recognizes the C4 C345C domain through a CCP exosite. Our results provide a unified structural framework for understanding the early and essential step of C4 cleavage in the elimination of pathogens and altered self through two major pathways of complement activation.
Synthesis and Structural Characterization of a Unique Octanuclear Bismuth(III) Thiosalicylate Complex with a Disk-like Cluster Core (1994)

Abstract The octanuclear bismuth(III) thiosalicylate complex, [Bi8(tsal)12(DMF)6](DMF)6 (H2tsal = thiosalicylic acid, DMF = N,N′-dimethylformamide), has been prepared and structurally characterized. The single crystal X-ray structure analysis has demonstrated that the eight Bi atoms form a disk-like cluster core and that each lone pair of two Bi atoms as the asymmetric unit is stereochemically activated.
Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System (2006)

Hepcidin, a key regulator of iron metabolism, is expressed in the liver, distributed in blood, and excreted in urine. However, to date, no reliable and practical method for measuring the bioactive form of hepcidin in serum has been developed. Here, we used surface-enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOF MS) to analyze the distinctive serum proteomic patterns of patients receiving hemodialysis. In the range of 1000 to 15,000 m/z, we found 3 peptides at 2192, 2789, and 2851 m/z that showed a significant correlation with the serum ferritin levels. The molecular sizes of peptides at 2192 and 2789 m/z matched with the reported sizes of hepcidin-20 and -25, respectively, and the serum peptide at 2789 m/z was identified as hepcidin-25 by collision-induced dissociation tandem MS. By using SELDI-TOF MS, we developed a semiquantitative assay for hepcidin-25. In this assay, the level of serum hepcidin-25 correlated well with levels of serum ferritin and serum interleukin-6. Hepcidin-25 was found to accumulate in the serum of patients receiving hemodialysis; this could contribute to the pathogenesis of renal anemia by decreasing the available iron for hematopoiesis. Thus, SELDI-TOF MS would be a clinically useful tool to detect and semiquantify bioactive hepcidin in serum.
Framewise and CTC training of Neural Networks for handwriting recognition (2015)

In recent years, Long Short-Term Memory Recurrent Neural Networks (LSTM-RNNs) trained with the Connectionist Temporal Classification (CTC) objective won many international handwriting recognition evaluations. The CTC algorithm is based on a forward-backward procedure, avoiding the need of a segmentation of the input before training. The network outputs are characters labels, and a special non-character label. On the other hand, in the hybrid Neural Network / Hidden Markov Models (NN/HMM) framework, networks are trained with framewise criteria to predict state labels. In this paper, we show that CTC training is close to forward-backward training of NN/HMMs, and can be extended to more standard HMM topologies. We apply this method to Multi-Layer Perceptrons (MLPs), and investigate the properties of CTC, namely the modeling of character by single labels and the role of the special label.
Chemical Characterization of Different Sumac and Pomegranate Extracts Effective against Botrytis cinerea Rots (2015)

Pomegranate (Punica granatum L.) peel and sumac (Rhus coriaria L.) fruit and leaf extracts were chemically characterized and their ability to inhibit table grape (cv. Italia) rots caused by Botrytis cinerea was evaluated on artificially inoculated berries. Different extraction methods were applied and extracts were characterized through Ultra Fast High Performance Liquid Chromatography coupled to Photodiode array detector and Electrospray ionization Mass spectrometer (UPLC-PDA-ESI/MSn) for their phenol and anthocyanin contents. The concentrated pomegranate peel extract (PGE-C) was the richest in phenols (66.97 g gallic acid equivalents/kg) while the concentrated sumac extract from fruits (SUF-C) showed the highest anthocyanin amount (171.96 mg cyanidin 3-glucoside equivalents/kg). Both phenolic and anthocyanin profile of pomegranate and sumac extracts were quite different: pomegranate extract was rich in cyanidin 3-glucoside, pelargonidin 3-glucoside and ellagic acid derivatives, while sumac extract was characterized by 7-methyl-cyanidin 3-galactoside and gallic acid derivatives. The concentrated extracts from both pomegranate peel and sumac leaves significantly reduced the development of Botrytis rots. In particular, the extract from pomegranate peel completely inhibited the pathogen at different intervals of time (0, 12, and 24 h) between treatment and pathogen inoculation on fruits maintained at 22-24 °C and high relative humidity (RH). This extract may represent a valuable alternative to control postharvest fungal rots in view of its high efficacy because of the low cost of pomegranate peel, which is a waste product of processing factories.
Jacksonville State University (1990)

The Serials Department at Jacksonville State University is in transition between the fully manual recordkeeping and materials tracking system of several years ago, and full integration with the recently installed NOTIS online public access catalog. Locally developed PC-based programs have helped bridge the gap between the manual and integrated systems by improving efficiency of workflow and materials control. Further automation through cancellation of little-used indexes and replacement by online literature searches on demand has helped contain ever-increasing serials costs. Future consolidation of eight current periodicals and reserve reading service desks in the subject divisions, and completion of the NOTIS implementation will enhance access while reducing staffing requirements.
System identification in communication with chaotic systems (2000)

Communication using chaotic systems is considered from a control point of view It is shown that parameter identification methods may be effective in building reconstruction mechanisms, even when a synchronizing system is not available. Three worked examples show the potentials of the proposed method.
Turbo embedded estimation with imperfect phase/frequency recovery (2004)

In recent years large scientific interest has been devoted to joint data decoding and parameter estimation techniques. In this paper, iterative turbo decoding joint to channel frequency and phase estimation is proposed. The phase and frequency estimator is embedded into the structure of the turbo decoder itself, taking into consideration both turbo interleaving and puncturing. Results show that the proposed technique outperforms conventional approaches both in terms of detection capabilities and implementation complexity.
Naked barley—Optimized recipe for pure barley bread with sufficient beta-glucan according to the EFSA health claims (2011)

Naked barley is an underutilized crop that is suitable for the production of functional food: it contains remarkable amounts of <i>β</i>-glucans, which are well known for their blood cholesterol and short-time blood sugar regulating properties and their impact on weight regulation. The aim of the present work was to develop naked barley bread with satisfying sensory characteristics and good baking qualities that could augment the intake of dietary fiber, especially <i>β</i>-glucans and therefore meet the requirements of the EFSA health claim for <i>β</i>-glucans. The results of the multiple response optimization suggest that the elevated use of water, malt flour and margarine in pure naked barley bread augment the sensory attractiveness whereas the use of acidifier and pre-gelatinized flour has a negative effect on the sensory quality.
Study on the synthesis and structure-activity relationship of 1,2,3-triazoles against toxic activities of Bothrops jararaca venom (2022)

Snakebite envenoming is a health concern and has been a neglected tropical disease since 2017, according to the World Health Organization. In this study, we evaluated the ability of ten 1,2,3-triazole derivatives AM001 to AM010 to inhibit pertinent <i>in vitro</i> (coagulant, hemolytic, and proteolytic) and <i>in vivo</i> (hemorrhagic, edematogenic, and lethal) activities of <i>Bothrops jararaca</i> venom. The derivatives were synthesized, and had their molecular structures fully characterized by CHN element analysis, Fourier-transform infrared spectroscopy and Nuclear magnetic resonance. The derivatives were incubated with the <i>B. jararaca</i> venom (incubation protocol) or administered before (prevention protocol) or after (treatment protocol) the injection of <i>B. jararaca</i> venom into the animals. Briefly, the derivatives were able to inhibit the main toxic effects triggered by <i>B. jararaca</i> venom, though with varying efficacies, and they were devoid of toxicity through <i>in vivo</i>, <i>in silico</i> or <i>in vitro</i> analyses. However, it seemed that the derivatives AM006 or AM010 inhibited more efficiently hemorrhage or lethality, respectively. The derivatives were nontoxic. Therefore, the 1,2,3-triazole derivatives may be useful as an adjuvant to more efficiently treat the local toxic effects caused by <i>B. jararaca</i> envenoming.
The analog local loop: a growing revolution in optical transmission (1989)

To provide an economic justification for the widespread deployment of optical fiber in the local loop, it may be necessary in some situations to install networks which will carry only telephony but can be upgraded to provide broadband services. Methods by which this may be achieved using analog carrier techniques are discussed. Passive optical networks (PONs) are considered, and the application of plain old telephone service (POTS) and broadband services over PONs is considered. Frequency planning and future trends are summarized.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Potential anticancer agents. XXVI. Spin Labelled Nitrosoureas (1985)

Abstract In order to obtain more information about the in vivo mechanism of action of nitrosoureas, the synthesis of spin labelled nitrosoureas derived from 1‐oxyl‐2.2.6.6‐tetramethyl‐4‐aminopiperidine was undertaken. The synthesis of four spin labelled ureas 4a–4d was reported as well as two spin labelled nitrosoureas:1‐methyl‐3‐(2′.2′.6′.6.′‐tetramethyl‐piperidin‐4′‐yl‐1′‐oxyl)‐1‐nitrosourea( 9a ) and 1‐(2′‐chloroethyl)‐3‐(2″,2″.6″.6″‐tetramethyl‐piperidin‐4″‐yl‐1″‐oxyl)‐nitrosourea (9b) . Their e.s.r. spectra were recorded. None of these compounds proved to be active against L1210.
Input-Series-Output-Parallel Connected DC/DC Converter for a Photovoltaic PCS with High Efficiency under a Wide Load Range (2010)

This paper proposes an input-series-output-parallel connected ZVS full bridge converter with interleaved control for photovoltaic power conditioning systems (PV PCS). The input-series connection enables a fully modular power-system architecture, where low voltage and standard power modules can be connected in any combination at the input and/or at the output, to realize any given specifications. Further, the input-series connection enables the use of low-voltage MOSFETs that are optimized for a very low RDSON, thus, resulting in lower conduction losses. The system costs decrease due to the reduced current, and the volumes of the output filters due to the interleaving technique. A topology for a photovoltaic (PV) dc/dc converter that can dramatically reduce the power rating and increase the efficiency of a PV system by analyzing the PV module characteristics is proposed. The control scheme, consisting of an output voltage loop, a current loop and input voltage balancing loops, is proposed to achieve input voltage sharing and output current sharing. The total PV system is implemented for a 10-kW PV power conditioning system (PCS). This system has a dc/dc converter with a 3.6-kW power rating. It is only one-third of the total PV PCS power. A 3.6-kW prototype PV dc/dc converter is introduced to experimentally verify the proposed topology. In addition, experimental results show that the proposed topology exhibits good performance.