gebhart/patrepeval huggingface dataset:
Long-term implantable medical wireless telemetry (2017)

This paper focuses on alternative materials for long-term monitoring of physiological parameters in vitro. In particular, we examine ZnO as a potential for both long-term sensors and antennas. ZnO has unique features such as high sensitivy and excellent biocompatibility that makes it a great candidate for such applications.
miR-140 Aggravates Chronic Obstructive Pulmonary Disease by Inducing Oxidative Stress in Diaphragm Cells by Targeting Nuclear Factor Erythroid 2-Related Factor 2 (2023)

Our research proposes to explore the function of miR-140 in the development of COPD. A COPD model was established in rats, and bronchial epithelial cells (BECs) were extracted in the present study, followed by transfection with mimic NC+inhibitor NC, miR-144 mimic, and miR-144 inhibitor. Significantly higher apoptotic rate; downregulated Bcl-2; upregulated Bax and caspase-3; promoted production of IL-6, IL-1 β , and MCP-1; higher ROS and MDA levels; lower SOD activity; and inactivated Nrf2 signaling were observed in miR-140 mimic-treated BECs, with opposite results observed in miR-140 inhibitor-treated BECs. The binding site between miR-140 and the 3′UTR region of Nrf2 was predicted and verified using the dual-luciferase gene reporter assay. COPD rats were administered with NC (agomir-NC and antagomir-NC), agomir-140, and antagomir-140. Compared to sham, dramatically lower pulmonary function, higher wet/dry value, severe pathological changes in lung tissues, higher release of inflammatory factors, enhanced apoptosis, higher ROS and MDA levels, lower SOD activity, and inactivated Nrf2 signaling were observed in the model and NC groups, which were greatly aggravated by agomir-140 and significantly reversed by antagomir-140. Collectively, our data suggest that miR-140 aggravates COPD by inducing OS in diaphragm cells by targeting Nrf2.
Immunostaining with dissociable antibody microarrays (2004)

The availability of a large number of biological materials such as cDNA, antibodies, recombinant proteins, and tissues has promoted the development of microarray technologies that make use of these materials in high-throughput screening assays. However, because microarray technologies have been less successful in examining proteins than DNA and mRNA, there is a need for improved protein microarray systems. To address this need, we developed an antibody microarray-based immunostaining method that can analyze the properties of a large number of proteins simultaneously. In this method, antibodies are arrayed and immobilized on a solid support and cells bearing antigens of interest are attached to a second support. Apposition of the two supports allows the antibodies to dissociate from the array support and bind to the cellular antigens. After separation of the supports, antigen-bound antibodies can be detected by standard secondary antibody techniques. These "dissociable" antibody arrays were used to detect both the expression and subcellular localization of a large number of specific proteins in various cultured cell types.
Stretch-Formability of Copper, Brass and Aluminium (1969)

The dependences of stretch-formability on crystallographic orientation and work hardening exponent n for metal sheets were investigated. The results showed that in aluminium single crystal plates stretch-formed the (100) oriented single crystal sheet has the best stretch-formability. Therefore copper sheets with various amounts of the (100)[001] orientation were stretch-formed and the effect of the (100)[001] orientation on the stretch-formability was studied.On the other hand, brass and aluminium sheets annealed at various temperatures were stretch-formed and the contribution of work hardening exponent n to the stretch-formability was studied. The results obtained are summarized as follows:(1) There is little effect of the crystallographic orientation on the stretch-formability.(2) Stretch-formability is nearly independent of strain ratio r.(3) Stretch-formability has little bearing on the observed values of work hardening exponent n at 10% strain, but it is considered that work hardening exponent at fracture represents the stretch-formability.(4) Elongation is closely related to the stretch-formability; the more the material is elongated in tension, the more excellent is it in strech-formability.
Characterization and Purification of the Mammalian COP9 Complex, a Conserved Nuclear Regulator Initially Identified as a Repressor of Photomorphogenesis in Higher Plants (1998)

Abstract The COP9 complex has been identified as a repressor of photomorphogenesis in Arabidopsis. Here we demonstrate that the COP9 complex is also present in mammals. Specific antibodies were generated against human counterparts of the Arabidopsis COP9 and COP11, the two known subunits of plant COP9 complex. Using these antibodies, we showed that indeed mammalian COP9 and COP11, also known as GPS1, could be coimmuno‐precipitated using either of the two specific antibodies, definitively confirming that they are physically part of the same complex. Further, the mammalian COP9 and COP11/GPS1 were cofractionated in the same large molecular weight fractions of about 500 kDa and were absent from the monomeric fractions. The mammalian COP9 complex was present in all organs examined but abundances vary. Indirect immunofluorescence studies suggested that the mammalian COP9 complex is largely nuclear localized. Both conventional biochemical and affinity purifications of the COP9 complex from pig spleen indicated that the mammalian COP9 complex consists of eight distinct subunits. These findings indicate that mammals also have a COP9 complex with conserved molecular composition and biochemical and cellular properties similar to the higher plant counterpart.
Evidenz für neoadjuvante Chemotherapie beim resektablen Pankreaskarzinom (2022)

Pancreatic cancer could be the second leading cause of cancer death in 2030. Even though 5-year survival rates remain poor, substantial progress has been made in recent decades. The use of adjuvant chemotherapy after resection has prolonged survival and neoadjuvant concepts have been introduced to allow proportionately more resections in initially borderline resectable or locally advanced disease. Currently, there is an ongoing debate about the use of neoadjuvant therapy in both resectable and borderline resectable disease, whereas in locally advanced cancer, the use of neoadjuvant therapies is unquestionable. High-level evidence in this area remains scarce, despite numerous studies that have recently been published or are currently recruiting. A key problem is the definition of resectability which was - traditionally - based on anatomical criteria; however, it has become clear that this definition is not adequate as tumour biology as well as patient-related prognostic factors are not taken into consideration. A second unsolved problem is the difficulty to standardise neoadjuvant therapy as - in contrast to the adjuvant setting, where large randomised controlled trials have set clear standards - multiple protocols are used around the world. This does not allow us to give any clear recommendation on which therapy protocol should be chosen for a specific patient if neoadjuvant therapy is considered. Furthermore, success control under neoadjuvant treatment is not effectively defined - usually only CA 19-9 as the most common marker can aid in clinical decision making, as imaging often fails to show actual response. With regard to present guidelines, patients with resectable disease should not be treated with neoadjuvant therapy outside clinical studies, whereas for borderline resectable disease, recommendations vary between different countries and societies.This review summarises the present literature on the topic of neoadjuvant therapy in pancreatic cancer with a focus on resectable disease stage.
The Preparation of Substituted 1(2H)-Isoquinolinones from Polylithiated 2-(2-Methylphenyl)Hydrazinecarboxylic Acid Esters (1996)

Abstract 2-(2-Methylphenyl)hydrazinecarboxylic acid esters were metalated with excess lithium diisopropylamide, and the resulting polyanion-type intermediates were condensed with aromatic esters followed by acid cyclization to the 3-substituted- 1 (2H)-isoquinolinones (isocarbostyrils).
ASHP Health-System Pharmacy 2015 Initiative (2004)

Journal Article ASHP Health-System Pharmacy 2015 Initiative Get access Charles E. Myers, M.S., M.B.A. Charles E. Myers, M.S., M.B.A. Group Vice President Professional Development and Member Services Offices Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 61, Issue 7, 1 April 2004, Page 657, https://doi.org/10.1093/ajhp/61.7.657 Published: 01 April 2004
Epidemiology and prevention of influenza in children in Argentina and Brazil (2017)

A group of influenza experts from Argentina and Brazil got together to discuss the burden of influenza in children, review current vaccine coverage rates in both countries, analyze vaccine effectiveness, and discuss strategies to improve prevention. Active surveillance of respiratory viruses is carried out nationwide in both countries. Years 2014 and 2015 were mild influenza seasons; influenza virus type A/H3N2 prevailed, whereas type B represented less than 30% of isolates. Trivalent inactivated influenza vaccine is included in National Immunization Programs for 1) children 6 months to 2 years old in Argentina; 2) children 6 months to 5 years old in Brazil; and 3) all high-risk individuals. Coverage rates in both countries were about 80% (albeit lower for the second dose). Experts from both countries proposed the following strategies to improve prevention: 1) increase surveillance; 2) assess effectiveness and long-term safety of influenza vaccines; 3) reinforce vaccination programs in order to increase coverage rates; and 4) consider introducing more effective vaccines, such as adjuvanted trivalent vaccines. In Argentina, estimating case-fatality rates was also recommended. Other proposed actions included enhancing education of health professionals and the lay community, and better use of communication resources to raise awareness of the burden of influenza and promote vaccine uptake.
Application of Nanotechnology to Improve the Performance of Biodegradable Biopolymer-Based Packaging Materials (2021)

There is great interest in developing biodegradable biopolymer-based packaging materials whose functional performance is enhanced by incorporating active compounds into them, such as light blockers, plasticizers, crosslinkers, diffusion blockers, antimicrobials, antioxidants, and sensors. However, many of these compounds are volatile, chemically unstable, water-insoluble, matrix incompatible, or have adverse effects on film properties, which makes them difficult to directly incorporate into the packaging materials. These challenges can often be overcome by encapsulating the active compounds within food-grade nanoparticles, which are then introduced into the packaging materials. The presence of these nanoencapsulated active compounds in biopolymer-based coatings or films can greatly improve their functional performance. For example, anthocyanins can be used as light-blockers to retard oxidation reactions, or they can be used as pH/gas/temperature sensors to produce smart indicators to monitor the freshness of packaged foods. Encapsulated botanical extracts (like essential oils) can be used to increase the shelf life of foods due to their antimicrobial and antioxidant activities. The resistance of packaging materials to external factors can be improved by incorporating plasticizers (glycerol, sorbitol), crosslinkers (glutaraldehyde, tannic acid), and fillers (nanoparticles or nanofibers). Nanoenabled delivery systems can also be designed to control the release of active ingredients (such as antimicrobials or antioxidants) into the packaged food over time, which may extend their efficacy. This article reviews the different kinds of nanocarriers available for loading active compounds into these types of packaging materials and then discusses their impact on the optical, mechanical, thermal, barrier, antioxidant, and antimicrobial properties of the packaging materials. Furthermore, it highlights the different kinds of bioactive compounds that can be incorporated into biopolymer-based packaging.
The variability of fibroadenoma in contrast-enhanced dynamic MR mammography. (1997)

The variability of fibroadenoma in contrast-enhanced dynamic MR mammography.U Brinck, U Fischer, M Korabiowska, M Jutrowski, A Schauer and E GrabbeAudio Available | Share
TWO NONNEGATIVE MATRIX FACTORIZATION METHODS FOR POLYPHONIC PITCH TRANSCRIPTION (2007)

Polyphonic pitch transcription consists of estimating the onset time, duration and pitch of each note within a music signal. Adaptive signal models such as Nonnegative Matrix Factorization (NMF) appear well suited to this task, since they can provide a meaningful representation whatever instruments are playing. In this paper, we propose a simple transcription method using minimum residual loudness NMF, harmonic comb-based pitch identification and threshold-based onset/offset detection, and investigate a second method incorporating harmonicity constraints in the NMF model. Both methods are evaluated in the framework of MIREX 2007 1. 1
Increasing the Diagnostic Yield and Accuracy of Bronchial Biopsy for the Assessment of Lung Cancer (2014)

Low-risk bronchoscopy techniques for retrieving biopsy samples for the diagnosis of lung cancer are hampered by low diagnostic yields, and trans-thoracic and surgical approaches carry higher intrinsic risk of complications. We are investigating the use of optical coherence tomography to increase the diagnostic yield and accuracy of bronchial biopsy.
Extended in vivo anterior eye-segment imaging with full-range complex spectral domain optical coherence tomography (2009)

We demonstrate the capability of full-range complex (FRC) spectral domain optical coherence tomography (SD-OCT) to image the anterior eye segment from the cornea to the posterior surface of the lens. With an adapted spectrometer design, we developed a SD-OCT system with an extended normal (single half-space) depth range of 7 mm (in air). This OCT-intrinsic depth range was doubled with a FRC technique. We demonstrate the performance of our OCT system by imaging the whole anterior segment of a healthy human eye in vivo.
Improving Coverage Deployment for Dynamic Nodes using Genetic Algorithm in Wireless Sensor Networks (2015)

Wireless Sensor Network is a group of sensor nodes aimed to monitor various environmental conditions at the field locations. Eventually the sensed data is sent to a processing center. Each sensor node consists of a different number of sensors for sensing different parameters in the field area. The sensor nodes are usually equipped with a pair of limited alkaline battery. Achieving maximum coverage deployment is a major problem in wireless sensor networks. In the Existing system, by using the Random Deployment some nodes may get overlapping this will cause unbalanced structure. By using maximum coverage sensor deployment problem, the Coverage achieved only for static nodes. In the proposed system, a Genetic Algorithm is used to deploy Sensor Nodes for the Maximum coverage within the area, where the sensors are of different types. In this work, first analyze the total coverage area the WSN, identify the types of Sensor nodes and Coverage sensing distance, and calculate the coverage sensing distance for the combination of all sensor types based on radius of each node. Improving the deployment of Dynamic nodes for achieving maximum coverage deployment by using Genetic Algorithm. As a result, we were implemented this work in Java. This will show the best performance in coverage and network lifetime. Keywords: Coverage Deployment, Genetic Algorithm (GA), Wireless Sensor Networks (WSN)
On the number of digital straight line segments (1988)

A closed-form expression has been reported in the literature for L/sub N/, the number of digital line segments of length N that correspond to lines of the form y=ax+ beta , O<or= alpha , beta <1. The authors prove an asymptotic estimate for L/sub N/ that might prove useful for many applications, namely, L/sub N/=N/sup 3// pi /sup 2/+O(N/sup 2/ log N). An application to an image registration problem is given.<<ETX>>
Omega-3 Fatty Acids and Inflammation: Novel Interactions Reveal a New Step in Neutrophil Recruitment (2009)

Inflammation is a physiological response to tissue trauma or infection, but leukocytes, which are the effector cells of the inflammatory process, have powerful tissue remodelling capabilities. Thus, to ensure their precise localisation, passage of leukocytes from the blood into inflamed tissue is tightly regulated. Recruitment of blood borne neutrophils to the tissue stroma occurs during early inflammation. In this process, peptide agonists of the chemokine family are assumed to provide a chemotactic stimulus capable of supporting the migration of neutrophils across vascular endothelial cells, through the basement membrane of the vessel wall, and out into the tissue stroma. Here, we show that, although an initial chemokine stimulus is essential for the recruitment of flowing neutrophils by endothelial cells stimulated with the inflammatory cytokine tumour necrosis factor-alpha, transit of the endothelial monolayer is regulated by an additional and downstream stimulus. This signal is supplied by the metabolism of the omega-6-polyunsaturated fatty acid (n-6-PUFA), arachidonic acid, into the eicosanoid prostaglandin-D(2) (PGD(2)) by cyclooxygenase (COX) enzymes. This new step in the neutrophil recruitment process was revealed when the dietary n-3-PUFA, eicosapentaenoic acid (EPA), was utilised as an alternative substrate for COX enzymes, leading to the generation of PGD(3). This alternative series eicosanoid inhibited the migration of neutrophils across endothelial cells by antagonising the PGD(2) receptor. Here, we describe a new step in the neutrophil recruitment process that relies upon a lipid-mediated signal to regulate the migration of neutrophils across endothelial cells. PGD(2) signalling is subordinate to the chemokine-mediated activation of neutrophils, but without the sequential delivery of this signal, neutrophils fail to penetrate the endothelial cell monolayer. Importantly, the ability of the dietary n-3-PUFA, EPA, to inhibit this process not only revealed an unsuspected level of regulation in the migration of inflammatory leukocytes, it also contributes to our understanding of the interactions of this bioactive lipid with the inflammatory system. Moreover, it indicates the potential for novel therapeutics that target the inflammatory system with greater affinity and/or specificity than supplementing the diet with n-3-PUFAs.
Neo-classical minimax problems, thresholding and adaptive function (1996)

We study the problem of estimating 0 from data Y- N(O, Ca2) under squared-error loss. We define three new scalar minimax problems in which the risk is weighted by the size of 0. Simple thresholding gives asymptotically minimax estimates in all three problems. We indicate the relationships of the new problems to each other and to two other neo-classical problems: the problems of the bounded normal mean and of the risk-constrained normal mean. Via the wavelet transform, these results have implications for adaptive function estimation in two settings: estimating functions of unknown type and degree of smoothness in a global ?2 norm; and estimating a function of unknown degree of local Hilder smoothness at a fixed point. In the latter setting, the scalar minimax results imply: Lepskii's results that it is not possible fully to adapt the unknown degree of smoothness without incurring a performance cost; and that simple thresholding of the empirical wavelet transform gives an estimate of a function at a fixed point which is, to within constants, optimally adaptive to unknown degree of smoothness.
Real-time conversion from a single 2D face image to a 3D text-driven emotive audio-visual avatar (2008)

In this paper, we propose a complete pipeline of efficient and low-cost techniques to construct a realistic 3D text-driven emotive audio-visual avatar from a single 2D frontal-view face image of any person on the fly. This real-time conversion is achieved through three steps. First, a personalized 3D face model is built based on the 2D face image using a fully automatic 3D face shape and texture reconstruction framework. Second, using standard MPEG-4 FAPs (Facial Animation Parameters), the face model is animated by the viseme and expression channels and is complemented by the visual prosody channel that controls head, eye and eyelid movements. Finally, the facial animation is combined and synchronized with the emotive synthetic speech generated by incorporating an emotion transformer into a Festival-MBROLA text to neutral speech synthesizer.
References for Run-time Aggregate Selection with Strong Typing (2011)

Network packet processing often involves having the results of a database match or packet content search select the next program operation. Our packetC[1] language provides specialized aggregate data types, databases[2] for masked matching and searchsets[3] for packet payload search terms. It is common to chain operations on these types, so that the result of one operation selects the specific aggregate to use for the next operation. packetC offers a reference data type to support this kind of chaining. A packetC reference provides an abstract way to refer to one of the extended data type aggregates in source code. At runtime the reference construct's value will indicate a particular aggregate of the relevant type. Thus, this construct is a classic reference in the computer science sense of a mechanism for indirect variable access. Unlike a C++ reference our construct must be assignable to support chaining that is driven by runtime results. Unlike a C-style pointer our reference must have strong typing, since runtime recovery from an illegal reference value (indicating a nonexistent or inappropriate aggregate) is not practical in this unforgiving, high-speed domain. The paper illustrates practical applications and shows that compressed code from using references does not cause performance penalties.
CuH in a Bottle: A Convenient Reagent for Asymmetric Hydrosilylations (2005)

This group has shown that CuH complexed with the Takasago ligand is an excellent reagent for asymmetric hydrosilylation of various α,β-unsaturated carbonyl compounds. This paper describes a nice, stable ‘CuH in a bottle’ that provides retention of high enantioselectivities for long storage times (up to two months) of a 1 mM toluene solution of this reagent. The copper source for the CuH species showed different reactivity depending on the counter anion. This catalyst also proved to be robust enough for a microwave reaction showing high conversion and enantioselectivity. The presence of Ph3P was shown to reduce the ee and 1H NMR spectroscopy revealed a catalyst (1) hydride peak at 2.55 ppm that differs from the achiral Ph3P-coordinated complex showing a hydride peak at 3.52 ppm.