gebhart/patrepeval huggingface dataset:
Tribbles in inflammation (2015)

Inflammation is part of the physiological innate immune response to invading pathogens and tissue injury. However, unresolved inflammation leads to human disease. The tribbles (TRIB) family of pseudokinase proteins has been shown to modulate key inflammatory signalling pathways, including the MAPK (mitogen-activated protein kinase) and PI3K (phosphoinositide 3-kinase) networks. This review summarizes our current knowledge on TRIBs in the context of inflammation, both at the level of molecular mechanisms and in disease development.
Comparative Pharmacodynamics of Gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa (2006)

Aminoglycosides are often used to treat severe infections with gram-positive organisms. Previous studies have shown concentration-dependent killing by aminoglycosides of gram-negative bacteria, but limited data are available for gram-positive bacteria. We compared the in vitro pharmacodynamics of gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa. Five S. aureus strains were examined (ATCC 29213 and four clinical isolates). Time-kill studies (TKS) in duplicate (baseline inocula of 10(7) CFU/ml) were conducted to evaluate bacterial killing in relation to increasing gentamicin concentrations (0 to 16 times the MIC). Serial samples were obtained over 24 h to quantify bacterial burden. Similar TKS with P. aeruginosa ATCC 27853 were conducted, and the time courses of the all bacterial strains were mathematically modeled for quantitative comparison. A dose fractionation study (using identical daily doses of gentamicin) in an in vitro hollow-fiber infection model (HFIM) over 5 days was subsequently used for data validation for the two ATCC strains. Model fits to the data were satisfactory; r(2) values for the S. aureus and P. aeruginosa ATCC strains were 0.915 and 0.956, respectively. Gentamicin was found to have a partially concentration-dependent killing effect against S. aureus; concentrations beyond four to 8 times the MIC did not result in significantly faster bacterial killing. In contrast, a concentration-dependent profile was demonstrated in suppressing P. aeruginosa regrowth after initial decline in bacterial burden. In HFIM, thrice-daily gentamicin dosing appeared to be superior to once-daily dosing for S. aureus, but they were similar for P. aeruginosa. Different killing profiles of gentamicin were demonstrated against S. aureus and P. aeruginosa. These results may guide optimal dosing strategies of gentamicin in S. aureus infections and warrant further investigations.
Pilot study of a novel treatment for androgenetic alopecia using enriched cell culture medium: clinical trials (2003)

Androgenetic Alopecia (AA) afflicts a large part of the population and of the many treatments available today none is completely satisfactory. Testing the efficacy and safety of a novel topical treatment for AA which is based on cell culture medium supplemented with insulin, thyroxin and growth hormone (CCM). The 48 participants classified as androgenetic alopecia Type II, III or IV on the Hamilton scale, concluded a randomized, vehicle-controlled, double-blind trial of 6 months duration. Under occlusive cover the gel was self applied for at least 3 hours daily. Evaluation was based on hair counts, investigator global assessment and participants self-administered questionnaire. Cessation of hair loss was reported by most participants within 28 weeks, and further confirmed by the hair count (HC) in ~80% of participants. Moreover, as early as 4 months after the start of the treatment, a time dependent increase of up to 50% in HC was observed. The average change in HC between the two groups differed significantly (p=0.007), with values of 4.1% for control and 13.8% for CCM. Following 4 months of treatment, a time dependent increase in HC (>10%) above minimal was observed in 55% of the CCM and 25% of the control and this trend continued. At 6 months 63% of the CCM and 33% of the control group exhibited increase of HC higher than 10%. The average increase in HC in the CCM and the control groups was 17.1% and 8.9% respectively (p=0.035). Self evaluation questionnaires revealed a time dependent increase in satisfaction in the CCMusers compared to the control. While the average score at T2 was similar in CCM and control (2.7 and 2.6 respectively), the score at T6 in the CCM increased to 5.9 and decreased to -0.4 in the control (p=0.007). Global-clinical evaluation following six months treatment revealed significantly (p=0.02) more hair loss in the control group (40%) compared to the CCM (7%) treated group. CCM was found effective in treating androgenetic alopecia in men. It induced cessation of hair loss, increased rate of hair growth and appearance of new hair. No side effects were reported or observed.
A design of vector filter banks (2002)

Vector filter banks (VFB's) can represent filter banks using a block sampling and the vector transforms. They are also appropriate to vector quantization. In the conventional study of VFB's, their polyphase representations and perfect reconstruction (PR) conditions have been given. However, no design method for VFB's has been given. This paper proposes a design method for VFB's using DFT modulation. First, we derive a polyphase representation using DFT modulation where the block size is the multiple of the number of channels. The efficient matrix representations are also presented in which the FFT algorithm can be used. Next, we propose a realization method for PR. We show that PR conditions are described by linear equations, and PR can be realized using larger-length analysis filters compared with that of scalar DFT modulated FIR filter banks. Finally, we show a design example of proposed VFB's.
10,000 gold for 20 dollars (2012)

Buying virtual currencies with real money from a third-party often violates the terms of use of online games. This study quantitatively investigates players who buy in-game gold from a third-party in World of Warcraft. A cross-cultural survey dataset of 2865 players reveals that differences between Asian and Western players are negligible compared to differences across genders, job categories, and play motivations. Our findings have implications for the design and study of interactions between players and virtual currencies.
<title>Satellite signature effects by ranging system and satellite attitude</title> (1997)

Residuals of AJISAI ranging data are investigated for single-photon detection and multi-photon detection by comparing our simulation model with actual range data. The simulated distribution histogram for a single-photon system based on our model agrees well with that obtained by the Herstmonceux station. We also found the variations in the AJISAI's center-of-mass correction for multi-photon systems was linked to the satellite attitude as a result of doing a spectral analysis of the Orroral station's data.
ChemInform Abstract: STUDIES OF ACYL AND THIOACYL ISOCYANATES PART 12, THE REACTIONS OF BENZOYL AND THIOBENZOYL ISOCYANATES WITH SULFONIUM YLIDES AND WITH DIAZOALKANES (1973)

Abstract Die Isocyanate (I) reagieren mit dem aus dem entsprechenden Sulfoniumbromid mit NaH in THF erzeugten Sulfoniumylid (IIa) unter Bildung der Ylide (IIIa).
Goffman Sat on My Immediate Left at a Long, Oblong Table in a Room in the Social Science Building (2009)

Arnold Glass wrote this memoir at the invitation of Dmitri Shalin and approved posting the present version in the Erving Goffman Archives.
A feedback system for the treatment of scoliosis (2002)

This paper describes a low-power system which will be used to measure topographical features of the trunk. Low frequency, magnetic-field theory was used to develop an electromagnetic based measurement system to determine the three dimensional position and orientation of a receiver relative to a transmitter. Experimental results were compared to theory to determine the accuracy of the system. The smallest distance and the angle that can be detected by the system is 5 mm (range 30 to 45 cm) and 0.5 degrees. The system will be further developed to provide feedback to scoliotic patients to assist them in reducing their spinal deformity.
Alkynylpyrenes as Improved Pyrene‐Based Biomolecular Probes with the Advantages of High Fluorescence Quantum Yields and Long Absorption/Emission Wavelengths (2005)

The photochemical properties of various alkynylpyrene derivatives have been investigated in detail with a view to developing a new class of pyrene-based biomolecular probes. The absorption maxima of the alkynylpyrenes were seen to be shifted to longer wavelengths compared with those of the unsubstituted parent pyrene. Fluorescence quantum yields of the alkynylpyrenes dramatically increased up to 0.99 in ethanol, and only slight quenching of the fluorescence occurred even under aerated conditions. The alkynylpyrenes have been successfully introduced into representative biomolecules such as peptides, proteins, and DNAs. The detectabilities of the labeled biomolecules were significantly improved, with the unique photochemical characteristics of the pyrene nucleus being maintained.
An Approach of Designing a High Voltage Interconnection Level Shifter LDMOS (800 V) using Floating Poly Field Plate Method (2010)

In this paper, we present a 3-dimensional analytical consideration of high-voltage-interconnection (HVI) effect along with 2-dimensional study using floating-poly-field-plate (FPFP) method to compensate the HVI effect for ultra-high-voltage (UHV) 800 V lateral-diffused metal-oxide-semiconductors (LDMOS). Crossing the HVI metal line above the UHV p-n junction structure would deteriorate the breakdown voltage for almost 65 – 70% from the original breakdown. As compared with the conventional method, FPFP method would drastically reduced the influence of the interconnection, from 67% to less than 10%, giving rise to breakdown voltage sustained above 800 V. Furthermore, the study of different FPFP design scheme, poly field plate length variation, interlayer dielectric oxide charge and p-top mask design layout consideration are also studied in this paper.
Feedback Control Of The Intensity Noise Of Injection Locked Lasers (1998)

Injection locking has been demonstrated to be a very effective method of intensity noise suppression [1]. However, the intensity noise of an injection locked laser at low frequencies is dominated by noise due to its pump source and, as such, is relatively unaffected by the process of injection locking. Also, at frequencies near the slave laser’s resonant relaxation oscillation (RRO), the injection locked laser amplifies the intensity noise of the master laser. In this work we will demonstrate an intensity noise suppression system that corrects both of these problems whilst also taking advantage of the benefits associated with using an injection locked laser.
Narrative review: predicting future molecular and clinical profiles of prostate cancer in the United States (2021)

Prostate cancer represents the most frequent tumor in men, accounting for the 21% of all diagnosed tumors, with 191,930 new cases and 33,330 deaths estimated in 2020. Advanced prostate cancer represents a heterogeneous disease, ranging from hormone naive or hormone sensitive to castration resistant. The therapeutic armamentarium for this disease has been implemented in the last years by novel hormonal therapies and chemotherapies. However, the percentage of patients who achieve complete responses still results negligible. On this scenario, the design of clinical trials investigating new therapeutic approaches represent a dramatic medical need. Predicting cancer incidence may be fundamental to design specific clinical trials, to optimize the allocation of economic resources, and to plan future cancer control programs. <i>ERG</i>, <i>SPOP</i> and DDR genes alterations can act as therapeutic targets in prostate cancer patients and can be tested to identify a gene-selected patient population to enrol in specific trials. According to our predictions, <i>ERG</i> gene fusions will be the most predominant molecular subtype, accounting for 69,050 new cases in 2030. Mutation in <i>SPOP</i> gene will be diagnosed in 16,512 tumors, corresponding to the number of cases associated with alterations in DDR genes (including 7,956 <i>BRCA2</i> mutated tumors). In this article, we analyzed and discussed the future molecular and clinical profiles of prostate cancer in the United States, aimed to describe a series of distinct subpopulations and to quantify potential clinical trial candidates in the next years.
Opioid agonist and antagonist activities of morphindoles related to naltrindole (1992)

A series of naltrindole-related ligands (4-10) with an N-methyl,N-phenethyl,N-cinnamyl, or an unsubstituted basic nitrogen were synthesized and tested for opioid agonist and antagonist activity in smooth muscle preparations and in mice. The nor compounds (4 and 6) and the phenethyl derivatives (5 and 8) displayed full agonist activity (IC50 = 85-179 nM) in the mouse vas deferens preparation (MVD) while the other members of the series exhibited partial agonist or weak antagonist activity. In the guinea pig ileum preparation (GPI), all compounds except 8 were partial agonists. The ligands that were evaluated in mice were found to produce antinociception that was not selectively mediated via delta opioid receptors. However, two of these ligands (4 and 5) appeared to be delta-selective opioid receptor antagonists at subthreshold doses for antinociception. The finding that all of the compounds bind selectively to delta opioid receptors in guinea pig brain membranes together with the in vitro pharmacology and in vivo antagonist studies suggests that the lack of delta agonist selectivity in vivo may be due to a number of factors, including a basic difference between the delta receptor system in the MVD and in the mouse brain. Further, it is suggested that the constellation of message and address components in the morphindole nucleus may tend to stabilize delta receptors in the brain in antagonist state.
Soft VAD in Factor Analysis Based Speaker Segmentation of Broadcast News (2016)

In this work we propose to integrate a soft voice activity detection (VAD) module in an iVector-based speaker segmentation system.As speaker change detection should be based on speaker information only, we want it to disregard the nonspeech frames by applying speech posteriors during the estimation of the Baum-Welch statistics.The speaker segmentation relies on speaker factors which are extracted on a frame-byframe basis using an eigenvoice matrix.Speaker boundaries are inserted at positions where the distance between the speaker factors at both sides is large.A Mahalanobis distance seems capable of suppressing the effects of differences in the phonetic content at both sides, and therefore, to generate more accurate speaker boundaries.This iVector-based segmentation significantly outperforms Bayesian Information Criterion (BIC) segmentation methods and can be made adaptive on a file-by-file basis in a two-pass approach.Experiments on the COST278 multilingual broadcast news database show significant reductions of the boundary detection error rate by integrating the soft VAD.Furthermore, the more accurate boundaries induce a slight improvement of the iVector Probabilistic Linear Discriminant Analysis system that is employed for speaker clustering.
Supplementary Figure S2 from Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML (2023)

&lt;p&gt;Supplemental Figure 2 shows PIM1 levels over time, GSEA data demonstrating increased PIM expression and Western blot images of PIM isoforms in all other cell lines&lt;/p&gt;
Integration and Application of Microlens Arrays Within Heads-Up Displays (2018)

The proposed work targets a fundamental challenge in heads-up display technology-in that such displays must bring about tight imaging with a flat form factor to support integration within eyewear. A Gabor superlens, being coupled plano-concave and plano-convex microlens arrays (MLAs), is developed to meet this challenge. The MLAs are designed and optimized, via tradespace analyses and ray-based simulations, and then formed with a specialized fabrication process. The process applies plasma pretreatment to the substrate followed by dispensing, curing, and casting of microlenses on the substrate to realize arrays with the necessary diameters and radii of curvature. The plano-concave and plano-convex MLAs are coupled to form the superlens, which is packaged with a baffle and microdisplay to function as the heads-up display. Ray-based simulations and experimental characterizations are carried out on the modulation transfer function of the display to define its resolution. It is found that the superlens can bring about strong imaging performance-with a resolution of up to 30 cycles/mm-as well as the tight imaging and flat form factor that are needed for emerging heads-up display technologies.
Characterization and Risk Factor Analysis of Osteoporosis in a Large Cohort of Patients with Chronic Graft-versus-Host Disease (2016)

The National Institutes of Health Chronic Graft-versus-Host Disease (cGVHD) Consensus Project Ancillary and Supportive Care Guidelines recommend annual assessment of bone mineral density (BMD) to monitor bone health. The study of osteoporosis in patients with cGVHD has been limited to small numbers of patients, and the guidelines are based on experience with other chronic diseases and expert opinion. We hypothesized that the prevalence of osteoporosis is high in a cohort of 258 patients with moderate to severe cGVHD because of prolonged exposure to risk factors for osteoporosis after allogeneic hematopoietic stem cell transplantation. We defined osteoporosis using BMD criteria (T-score ≤-2.5) at 3 anatomic sites-the femoral neck (FN), lumbar spine (LS), and total hip (TH)-and characterized risk factors through univariate and multivariate analyses. We found that low body weight (FN, P < .0001; LS, P = .0002; TH, P < .0001), malnutrition (FN, P = .0002; LS, P = .03; TH, P = .0076), higher platelet count (FN, P = .0065; TH, P = .0025), higher average National Institutes of Health organ score (FN, P = .038), higher prednisone dose (LS, P = .032), lower complement component 3 (LS, P = .0073), and physical inactivity (FN, P = .01) were associated with osteoporosis in at least 1 site. T-scores were significantly lower in the FN compared with the LS or TH (P < .0001 for both). The prevalence of osteoporosis and osteopenia was high (17% and 60%, respectively), supporting current recommendations for frequent monitoring of BMD. The association of higher platelet count in patients with cGVHD and osteoporosis has not been reported previously and represents a new area of interest in the study of osteoporosis after allogeneic hematopoietic stem cell transplantation.
Excimer laser processing for the integrated gamma-ray detectors (2003)

Selective operation of laser doping process and laser ablation process using KrF excimer laser irradiation (wavelength 248nm, pulse duration 20ns) was carried out that is used for fabricating an integrated gamma-ray imaging detector. At high vacuumed condition, laser irradiated surface region is heated up to ablated. At high-pressure condition, ablation is suppressed and impurity on the surface was melt and diffuse into the CdTe substrate. We have fabricated an integrated imaging detector using above combination process. The detector showed low leakage current at room temperature and good gamma-ray detection property.
Influence of instrument transformers on power system protection (2005)

Instrument transformers are a crucial component of power system protection.\nThey supply the protection system with scaled-down replicas of current and voltage\nsignals present in a power network to the levels which are safe and practical to op-\nerate with. The conventional instrument transformers are based on electromagnetic\ncoupling between the power network on the primary side and protective devices on\nthe secondary. Due to such a design, instrument transformers insert distortions in the\nmentioned signal replicas. Protective devices may be sensitive to these distortions.\nThe inuence of distortions may lead to disastrous misoperations of protective devices.\nTo overcome this problem, a new instrument transformer design has been devised:\noptical sensing of currents and voltages. In the theory, novel instrument transform-\ners promise a distortion-free replication of the primary signals. Since the mentioned\nnovel design has not been widely used in practice so far, its superior performance\nneeds to be evaluated. This poses a question: how can the new technology (design)\nbe evaluated, and compared to the existing instrument transformer technology? The\nimportance of this question lies in its consequence: is there a necessity to upgrade\nthe protection system, i.e. to replace the conventional instrument transformers with\nthe novel ones, which would be quite expensive and time-consuming?\nThe posed question can be answered by comparing inuences of both the novel\nand the conventional instrument transformers on the protection system. At present,\nthere is no systematic approach to this evaluation. Since the evaluation could lead to\nan improvement of the overall protection system, this thesis proposes a comprehensive\nand systematic methodology for the evaluation. The thesis also proposes a complete\nsolution for the evaluation, in the form of a simulation environment. Finally, the\nthesis presents results of evaluation, along with their interpretation.
Modelling Human Regulatory Variation in Mouse: Finding the Function in Genome-Wide Association Studies and Whole-Genome Sequencing (2012)

An increasing body of literature from genome-wide association studies and human whole-genome sequencing highlights the identification of large numbers of candidate regulatory variants of potential therapeutic interest in numerous diseases. Our relatively poor understanding of the functions of non-coding genomic sequence, and the slow and laborious process of experimental validation of the functional significance of human regulatory variants, limits our ability to fully benefit from this information in our efforts to comprehend human disease. Humanized mouse models (HuMMs), in which human genes are introduced into the mouse, suggest an approach to this problem. In the past, HuMMs have been used successfully to study human disease variants; e.g., the complex genetic condition arising from Down syndrome, common monogenic disorders such as Huntington disease and β-thalassemia, and cancer susceptibility genes such as BRCA1. In this commentary, we highlight a novel method for high-throughput single-copy site-specific generation of HuMMs entitled High-throughput Human Genes on the X Chromosome (HuGX). This method can be applied to most human genes for which a bacterial artificial chromosome (BAC) construct can be derived and a mouse-null allele exists. This strategy comprises (1) the use of recombineering technology to create a human variant-harbouring BAC, (2) knock-in of this BAC into the mouse genome using Hprt docking technology, and (3) allele comparison by interspecies complementation. We demonstrate the throughput of the HuGX method by generating a series of seven different alleles for the human NR2E1 gene at Hprt. In future challenges, we consider the current limitations of experimental approaches and call for a concerted effort by the genetics community, for both human and mouse, to solve the challenge of the functional analysis of human regulatory variation.
Computational methods for linear control systems (1991)

Numerical matrix computations linear control systems solution of state equations stability, controllability and observability computations pole assignment solution of matrix Riccati equations computations in geometric linear systems theory.