gebhart/patrepeval huggingface dataset:
RESPOSTAS ESTRATÉGICAS AO AMBIENTE LEGAL: VIAS DE INSTITUCIONALIZAÇÃO DA QUALIDADE DE ENSINO EM IES PRIVADAS DO ESTADO DE SÃO PAULO-BRASIL. (2010)

O principal objetivo deste estudo foi analisar a relação entre padrões ambientais-institucionais relativos a qualidade de ensino superior na legislação brasileira, padrões interpretativos e respostas estratégicas de organizações de ensino superior (IES) do Estado de São Paulo. O método que caracteriza a pesquisa é o estudo comparativo de casos. Foram utilizados dados secundários (legislação brasileira de ensino e publicações feitas pelas IES pesquisadas) e dados primários (obtidos por questionário e entrevistas semi-estruturadas). O questionário, enviado a 420 IES privadas de São Paulo, permitiu classificar, mediante procedimentos estatísticos multivariados, 44 IES respondentes em dois grupos: Conformidade Parcial e Não-Conformidade Parcial. A partir de escolha proposital, selecionaram-se 9 casos nos quais se realizou 21 entrevistas, cujos dados foram analisados mediante análise de conteúdo e mapas cognitivos. Concluiu-se principalmente que entre IES do Grupo 1 os parâmetros de qualidade foram interpretados predominantemente como fonte de eficiência no ensino, enquanto entre as IES do Grupo 2 eles foram interpretados como fonte de legitimidade, indicando-se duas vias de institucionalização daqueles critérios e procedimentos de avaliação. Outras conclusões relativas ao ambiente institucional na perspectiva dos dirigentes são também discutidas.STRATEGIC RESPONSES TO LEGAL ENVIRONMENT: THE INSTITUTIONALIZATION OF HIGH EDUCATION QUALITY IN SÃO PAULO STATE ABSTRACTWe report a research about the relation among regulative patterns concerned to High Education quality standards, interpretive schemes and strategic responses in private High Education Organizations (IES) in São Paulo State, Brazil. This is a comparative study of cases. Data were collected by questionaries and interviews with managers of High Education Organizations based on São Paulo State, Brazil. We used content and multivariate techniques as strategy for analysing data. Based on those techniques, our results suggest that legal standards of educational quality enforced by Brazilian Government from 1995 to 2003 were institutionalized in two senses in those IES. In a first group of IES those standards were perceived mainly as a source of efficiency (to follow those requirements was reported as necessary to offer good education); in a second group the requirements were perceived only as a source of legitimacy (a way of avoiding to be punished by Government and society). We conclude that institutionalization in those cases should be understood as a complex phenomenon affecting organizational behaviors and their symbolic systems in different ways. That suggests that to understand institutionalization processes it is not enough to focus on observable environment patterns.
The Synthesis of Spin - Labeled Imipramine Analogs (1984)

Abstract Spin - labeled drugs have proved to be a valuable investigative tool in the study of drug - membrane and drug - receptor interactions1. Since we are interested in the membrane action of tricyclic antidepressants, we have decided to synthetize some spin - labeled analogs of imipramine. These compounds are expected to be useful paramagnetic probes which could be used in further elucidation of interactions of tricyclic antidepressants with membranes and receptors.
Dynamic Effects Caused by SPMT Bridge Moves (2019)

This study provides the result of dynamic effects of self-propelled modular transporter (SPMT) movements during a simulated bridge transport. Accelerometers were attached to an SPMT and different transport scenarios were simulated under several loading conditions. For the vertical direction, a traverse of uneven terrain provided the peak platform acceleration (PPA), whereas a rapid start-and-stop motion controlled both longitudinal and transverse directions. The observed PPA increased as the total weight decreased. Vertical accelerations were found to be highly dependent on the SPMT speed. The horizontal accelerations were not affected by the speed of the SPMT, but they were affected by the ability of the operator to perform a braking operation. Response spectra suitable for the design for each direction were constructed from the time history graphs corresponding to these tests. The maximum pseudo accelerations (MPAs) for heavy, medium, and light load cases were 0.68, 1.07, and 2.3g in the vertical direction; they were significantly more than the horizontal direction with 0.32g for heavy, 0.47g for medium, and 0.60g for the light load case. The dynamic forces on the cargo (falsework or bridge) either increased or stayed constant as the stiffness of the system increased. Although vertical accelerations, which mostly affect the bridge superstructure components, can be reduced by limiting the SPMT speed, the horizontal accelerations can be reduced because some ductility and inelasticity within the bracing of the falsework and response modification factors may be applied to the developed spectra. Dynamic dead load impact (DLI) factors were found to be in excess of those often used for the design because of the worst-case nature of the presented results.
Abstract 2584: Specific antitumor activity of the splicing modulator sudemycin and cooperation with ibrutinib in chronic lymphocytic leukemia (2015)

Abstract Chronic lymphocytic leukemia (CLL) is the most frequent adult leukemia in western countries. A core component of the spliceosome, SF3B1, is among the most frequently mutated genes in CLL affecting up to 5-18% of patients. Clinically, SF3B1 mutations correlate with a more aggressive behavior of the disease, poorer clinical outcome and shorter time to treatment, as well as treatment refractoriness. Consistent with the crucial role of the spliceosome in CLL, mutations in other genes of the mRNA splicing, processing and transport machinery are also found to be frequently mutated in this tumor. Thus, our aim was to evaluate the antitumor effect of the spliceosome modulator sudemycin in SF3B1-mutated and -unmutated CLL cells in the in vitro and in vivo settings. For this purpose, cytotoxicity was measured by flow cytometry, in vivo activity of the compound was evaluated in an adoptive transfer mouse model of CLL, splicing products were analyzed by RT-PCR with specific primers and NF-κB activity was determined with the TransAM NF-κB p65 kit. Our results demonstrate that the spliceosome modulator sudemycin showed selective cytotoxicity in primary CLL cells when compared with healthy lymphocytes and tumor cells from other malignancies, with a slight bias for CLL cases with mutations for spliceosome-RNA maturation genes. Consistently, sudemycin exhibited considerable antitumor activity in a xenograft CLL model. At the molecular level, the antileukemic effect of sudemycin involved the splicing modulation of several target genes important for tumor survival, both in SF3B1-mutated and -unmutated cases. Thus, the apoptosis induced by this compound was related to the alternative splicing switch of MCL1 toward its proapoptotic isoform. Sudemycin also functionally disturbed NF-κB pathway through the induction of a spliced RELA variant lacking its DNA binding domain. Importantly, we show that the modulation of the alternative splicing of the inhibitor of Btk(IBTK) by sudemycin leaded to an enhanced antitumor effect in combination with ibrutinib. In conclusion, we provide first evidence that the spliceosome is a relevant therapeutic target in CLL, supporting the use of splicing modulators in combination with ibrutinib as a promising approach for the treatment of CLL patients. Citation Format: Sílvia Xargay-Torrent, Mónica López-Guerra, Laia Rosich, Arnau Montraveta, Jocabed Roldán, Vanina Rodríguez, Neus Villamor, Marta Aymerich, Chandraiah Lagisetti, Thomas R. Webb, Elias Campo, Dolors Colomer. Specific antitumor activity of the splicing modulator sudemycin and cooperation with ibrutinib in chronic lymphocytic leukemia. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2584. doi:10.1158/1538-7445.AM2015-2584
Surgical Treatment of Non-Union of the Carpal Scaphoid by Modified Matti-Russe Technique (1994)

Although 90% of fresh carpal scaphoid fracture heals with adequate treatment, the rate of non-union is higher in untreated or misdiagnosed at the time of injury leading to carpal collapse and degenerative arthritis. We have treated these non-unions by modified Matti-Russe technique and all cases showed uneventful healing, but range of motion of the wrist joint decreased in some cases. We studied 18 patients of non-union of the carpal scaphoid treated modified Matti-Russe technique from November, 1988 to December, 1992 and the results were as follows: 1. Among the 18 patients, the ratio of male and female was 16:2, and mean age was 23.0 years old. 2. Dominant hand was involved in 14 cases. 3. The fracture was most commonly situated at the waist of the scaphoid. 4. Bony union was obtained in all cases and the average time to radiological union was 18.0 weeks. 5. According to Maudsley's assessment, the results revealed as 7 cases of excellent, 9 cases of good and 2 cases of fair.
Phosphorescence and optically detected magnetic resonance studies of a class of anomalous tryptophan residues in globular proteins (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphorescence and optically detected magnetic resonance studies of a class of anomalous tryptophan residues in globular proteinsMartin V. Hershberger, August H. Maki, and William C. GalleyCite this: Biochemistry 1980, 19, 10, 2204–2209Publication Date (Print):May 13, 1980Publication History Published online1 May 2002Published inissue 13 May 1980https://pubs.acs.org/doi/10.1021/bi00551a032https://doi.org/10.1021/bi00551a032research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Water, sodium, potassium and chlorine balance during late pregnancy and early lactation in high-yielding dairy cows under winter Mediterranean conditions (1995)

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Unmanned Aircraft Capture and Control Via GPS Spoofing (2014)

The theory and practice of unmanned aerial vehicle (UAV) capture and control via Global Positioning System (GPS) signal spoofing are analyzed and demonstrated. The goal of this work is to explore UAV vulnerability to deceptive GPS signals. Specifically, this paper (1) establishes the necessary conditions for UAV capture via GPS spoofing, and (2) explores the spoofer's range of possible post‐capture control over the UAV. A UAV is considered captured when a spoofer gains the ability to eventually specify the UAV's position and velocity estimates. During post‐capture control, the spoofer manipulates the true state of the UAV, potentially resulting in the UAV flying far from its flight plan without raising alarms. Both overt and covert spoofing strategies are considered, as distinguished by the spoofer's attempts to evade detection by the target GPS receiver and by the target navigation system's state estimator, which is presumed to have access to non‐GPS navigation sensor data. GPS receiver tracking loops are analyzed and tested to assess the spoofer's capability for covert capture of a mobile target. The coupled dynamics of a UAV and spoofer are analyzed and simulated to explore practical post‐capture control scenarios. A field test demonstrates capture and rudimentary control of a rotorcraft UAV, which results in unrecoverable navigation errors that cause the UAV to crash.
Wave Haptics: Building Stiff Controllers from the Natural Motor Dynamics (2007)

Haptics, like the fields of robotics and motion control, relies on high stiffness position control of electric motors. Traditionally, DC motors are driven by current amplifiers designed to hide their electrical dynamics. Meanwhile encoder-based position feedback creates virtual springs. Unfortunately this cancellation-replacement approach experiences performance limits due to sensor quantization, discretization, and amplifier bandwidths. An alternate approach is presented, noting the inherent inductor-resistor dynamics of the motor are beneficial to the haptic task. Two main insights are followed, which may be utilized independently or preferably in combination. First, the electrical inductance L can serve as a stiffness, providing a natural sensorless coupling between the virtual environment and the user. Second, the electrical resistance R can create a natural wave transformation, providing a robust computer interface between the discrete and continuous time domains. The resulting analog circuit implements a simple voltage drive and can achieve higher stiffness than traditional approaches, especially in the frequency range where human users are most sensitive. A prototype 1-DOF system has been implemented and confirms the promise of this novel paradigm.
Real-Time Emulation of a Hydrogen-Production Process for Assessment of an Active Wind-Energy Conversion System (2008)

This paper presents the real-time emulation of a hydrogen-production process for assessment of an active wind- energy conversion system. The hardware-in-the-loop emulator of the electrolyzer consists of a power-electronic stage and a control stage. In the control board, the algorithmic equations of the electrolyzer modeling and its control should be implemented, as well as the emulator's power converter control. The causal ordering graph is used to model the electrolyzer and its auxiliary equipment. This model is capable of characterizing the relations among the different physical quantities and can be used to design the control system, ensuring an efficient and reliable operation of the electrolyzer. The proposed control method can manage the power and hydrogen flows. The simulation results have highlighted the variation domains and the relations among different physical quantities. The experimental results of the real-time emulation is based on a PHOEBUS advanced alkaline electrolyzer and shows the same electrical characteristics in real time with hardware.
Anti-tumor efficacy and PD-L1 expression in the tumor microenvironment after poxvirus-based active immunotherapy and PD-1 blockade. (2015)

3079 Background: Treatment with poxvirus-based active immunotherapies shows evidence of robust immune responses against a variety of tumor-associated antigens in preclinical and clinical studies. These active immunotherapies are in clinical trials to treat tumors expressing PSA (PROSTVAC/Phase 3), CEA and MUC-1 (CV-301/Phase 2), HER-2 (MVA-BN-HER2), and Brachyury (MVA-BN-Brachyury). Because these immunotherapies drive IFNγ-producing T cells to the tumor, we hypothesized that the tumors would upregulate PD-L1 in an attempt to evade the immune response. Thus, combination treatment of poxvirus-based immunotherapy with PD-1 axis blockade has the potential to yield therapeutic synergy against tumors in preclinical and clinical regimens. Methods: In therapeutic MC38-CEA and CT26-HER2 tumor models, mice were treated with CV-301 or MVA-BN-HER2, respectively, in combination with anti-PD-1 antibody. PD-L1 expression was evaluated in the tumor microenvironment by immunofluorescence and FACS. Results: Poxvirus-based immunotherapies induced activation and trafficking of antigen specific T cells that produce high levels of IFNγ in the tumor microenvironment.TumorPD-L1 expression was upregulated following CV-301 and MVA-BN-HER2 immunotherapy in vivo as measured by immunofluorescence. The PD-L1 expression was significantly elevated on tumor cells (p < 0.01) and infiltrating immune cells (p < 0.05) as measured by FACS. Combining poxvirus-based immunotherapy with PD-1 blockade in therapeutic mouse tumor models demonstrated synergistic anti-tumor efficacy. Conclusions: In preclinical studies, CV-301 and MVA-BN-HER2 poxvirus-based immunotherapies drive a robust, tumor-infiltrating T cell response that provokes tumor PD-L1 expression. Synergistic anti-tumor efficacy in mice resulted from combining active immunotherapy with PD-1 immune checkpoint inhibition. The potential of active immunotherapy to drive productive antigen specific T cell immunity could provide patients with PD-L1neg/low tumors an opportunity to benefit from PD-1/PD-L1 axis blockade when given in combination with poxvirus-based immunotherapies.
Vascularization of Muscle (2014)

Skeletal muscle has tremendous regenerative capacity, ensuring maintenance of tissue homeostasis and restoration of both structure and function after minor injury. However, adult skeletal muscle may not possess sufcient ability to recover anatomical structure and physiological functions after signicant tissue loss or damage resulting from trauma, tumor ablation, prolonged denervation, or myopathies (Bach, Beieret al. 2004; Wagers and Conboy 2005; Blau 2008). In such cases, surgical intervention is often necessary. However, conventional surgical procedures, such as autologous muscle transplantation and transposition, cause signicant donor site morbidity while only resulting in limited functional recovery (Bach, Beier et al. 2004).
Glycosylations de Diols-4,6 en SerieGlucoetManno, Utilises Comme Accepteurs, Avec des DonneursN-Allyloxycarbonyles de la Glucosamine (1989)

Abstract Glycosylations were realized with N-allyloxycarbonyl derivatives of D-glucosamine on 4, 6-diols of the gluco and manno series. Depending on the donor used (either a glucosyl bromide or a β-acetate) and on the stoichiometry of reactants, a good regioselectivity could be observed towards the primary hydroxyl group. When the OH-6 is glycosylated or esterified the above donors are effective glycosylating agents towards the C-4 hydroxyl group.
Phenotypes of young adults transitioning from paediatric to adult asthma services (2017)

<b>Introduction:</b> Transition from specialist paediatric to adult services is a crucial time &amp; while this process is well established in other chronic conditions (e.g. Cystic Fibrosis) there is a lack of information in an asthma setting. <b>Aims &amp; Objectives:</b> We were interested in the features of young adults (YAs) transitioning from paediatric to adult asthma services. <b>Methods:</b> We retrospectively reviewed our referrals from the paediatric sector over the last 4years. <b>Results:</b> All 42 referrals [40.5% female] transitioned between the ages of 16-18yrs. Almost half the males were below the 25th centile for height at the time of transition, while 50% of the females had an elevated BMI [median 25.0; IQR 8.0]. More YAs had an <i>eosinophilic</i> phenotype [median <i>Eos count</i> =0.7x10<sup>9</sup>/L; IQR 0.75] than <i>severe allergic</i> asthma [median <i>Total IgE</i> =829kU/L]. Overall &gt;60% were prescribed high-dose inhaled or regular oral corticosteroids (OCS). The majority [70.6%] of YAs transitioning took ≥5medications daily, despite this only a minority had adequate asthma control [ACQ-6 &lt;1 in 14.3%] &amp; levels of exhaled nitric oxide tended to be very high [median =159ppb; IQR 46] - although lung function was generally preserved [median predicted FEV1 =100.5%; IQR 22]. Prescription fulfilment rate was &lt;80% in n=4/5 checked electronically. Common comorbidities included atopy and mental health issues; worryingly a 16yr old on OCS developed posterior subcapsular cataracts. <b>Conclusion:</b> Our data suggests that YAs transitioning to adult specialist asthma services have poor disease control despite substantial treatment burdens. While adherence to treatment may be an issue, the majority of these YAs will meet criteria for anti-IL5 therapy when available.
Restarting a History-Matching Study for an Existing Reservoir Model (2005)

C02 RESTARTING A HISTORY-MATCHING STUDY FOR AN EXISTING RESERVOIR MODEL Abstract 1 Sometimes reservoir engineers want to update a previously built reservoir model to integrate newly collected data. Unfortunately the data used to generate the existing reservoir model are often lost. To avoid restarting the history-matching study from the very beginning we developed several techniques to infer the missing data. These data consist of a random function characterized by geostatistical parameters and a set of random numbers. The existing reservoir model is the realization associated to the estimated random numbers given the estimated random function. Once the random function and
Recovery of the Complete Data Set From Focused Transmit Beams (2017)

The focused transmit beam is a standard tool for clinical ultrasound scanning, concentrating energy from a number of array elements toward an imaging target. However, above and below the transmit focus, much of the energy in the beam is spread in a broadened main lobe and long off-axis tails that are ignored by conventional beamforming methods. This paper proposes a method to decompose a set of focused transmit beams into their constituent components-diverging waves from individual array elements. The recovery of this complete data set enables synthetic transmit focusing at all points in the field of view without beam shape or focal depth artifacts commonly associated with virtual source synthetic aperture beamforming. An efficient frequency-domain linear decoding implementation is introduced. The principles of the method are demonstrated both in transmit field simulations and experimental imaging. At depth, up to a 9.6-dB improvement in electronic signal-to-noise ratio and 8.9-dB improvement in contrast were observed in comparison with conventional dynamic receive beamforming. The proposed method is broadly applicable to existing scan sequences and requires only channel data for processing.