gebhart/patrepeval huggingface dataset:
Plasminogen activator inhibitor‐1 as a potential marker for the malignancy of gastric cancer (2006)

To test the hypothesis that plasminogen activator inhibitor-1 (PAI-1) may serve as a candidate marker for the malignancy of gastric cancer, we carried out quantitative reverse transcription-polymerase chain reaction for the PAI-1 gene and evaluated the possible relationship between PAI-1 gene expression levels and clinicopathological findings in gastric cancer. A significant increase in PAI-1 expression scores was observed in lymph node metastasis-positive gastric cancers (2.11 +/- 0.35) compared to metastasis-negative cancers (0.33 +/- 0.49) (P = 0.0048), as well as in distant metastasis-positive gastric cancers (3.68 +/- 0.58) compared to metastasis-negative cancers (1.20 +/- 0.32). The PAI-1 expression score markedly increased with tumor stage (P < 0.0001; ANOVA test). Moreover, multivariate analysis revealed the PAI-1 expression score to be a strong and independent prognostic factor for gastric cancer (P = 0.0450). These results suggested that PAI-1 might serve as a new and promising parameter for the prediction of prognosis in gastric cancer.
Prototyping Spatial Interactions (2021)

A growing field in the interaction design practice is the domain of connected and interactive spaces. The idea of ubiquitous computing, that was originated in the late 1980s and the beginning of the 1990s, is now seeking maturity, and technology trajectories have helped materialize the basic prerequisites for the proliferation of spatial computing. This paper illustrates how the design process for interactive environments can benefit from an emerging set of methodologies and tools, that is the physical counterpart for the successful creation of human-centered interactive experiences in space. When creating interactive spaces, a designer needs to take into consideration new dimensions, like the flow of users within the space, the spatial context, and a new set of sensors and actuators that go well beyond screens, keyboards, mice, or controllers. Unlike other interaction design domains, there is not a defined device, like a smartphone or personal computer, but instead, the technologies of spatial computing are a collection of distributed devices, sensors, and actuators. Due to this configuration the implementation and prototyping of interactive environments requires new tools to deal with the complexity of non-standard components to ease the design process and allow for sketching in hardware and software at scale. With ad hoc software and hardware designed with the purpose of standardizing and making accessible these components, a design practitioner can implement prototypes of interactive and connected spaces to gather inspirations, insights, and validation before investing in creating the complete experience. This paper explains how the process of designing with such tools will transform the work and the outcome of the interaction designer that explores the forefront domains of connected environments, ubiquitous media, and spatial computing.
Computer-Aided System for Casting Design Using Immersive Virtual Environment (2003)

The environment where Japanese industry has been paid with respect is changing tremendously due to the globalization of economics, where Asian countries are undergoing economical and technical development as well as advancing in information technology. With acceleration of manufacturing bases relocating abroad, industrial hollowing out is happening; hence effort to transfer the technology and the design knowledge of machine design in a company is becoming an important subject. For example, in the design of custom casing product, a designer who is lack of casting knowledge may not be able to produce a good design. In order to obtain a good design and manufacturing, it is necessary to equip the designer and manufacturer with a support system related to casting design or so called, knowledge transfer and creation system. This paper proposes a new computer-aided system for casing design, which is composed of the explicit and tacit knowledge transfer system using synchronised multimedia and the knowledge internalization system using immersive virtual environment. This system indicates that our proposed method is useful as a knowledge transfer and creation method for casting design.
Clinical utility and validity of the Functional Disability Inventory among a multicenter sample of youth with chronic pain (2011)

The Functional Disability Inventory (FDI) is a well-established and commonly used measure of physical functioning and disability in youth with chronic pain. Further validation of the measure has been called for, in particular, examination of the clinical utility and factor structure of the measure. To address this need, we utilized a large multicenter dataset of pediatric patients with chronic pain who had completed the FDI and other measures assessing pain and emotional functioning. Clinical reference points to allow for interpretation of raw scores were developed to enhance clinical utility of the measure, and exploratory factor analysis was performed to examine its factor structure. Participants included 1300 youth ages 8 to 18 years (mean=14.2 years; 76% female) with chronic pain. Examination of the distribution of FDI scores and validation with measures of depressive symptoms and pain intensity yielded 3 distinct categories of disability: No/Minimal Disability, Moderate Disability, and Severe Disability. Factor analysis of FDI scores revealed a 2-factor solution representing vigorous Physical Activities and non-physically strenuous Daily Activities. The 3-level classification system and factor structure were further explored via comparison across the 4 most commonly encountered pain conditions in clinical settings (head, back, abdominal, and widespread pain). Our findings provide important new information regarding the clinical utility and validity of the FDI. This will greatly enhance the interpretability of scores for research and clinical use in a wide range of pediatric pain conditions. In particular, these findings will facilitate use of the FDI as an outcome measure in future clinical trials.
Fundamentals of Ultra-Thin-Body MOSFETs and FinFETs (2013)

Understand the theory, design and applications of the two principal candidates for the next mainstream semiconductor-industry device with this concise and clear guide to FD/UTB transistors. • Describes FD/SOI MOSFETs and 3-D FinFETs in detail • Covers short-channel effects, quantum-mechanical effects, applications of UTB devices to floating-body DRAM and conventional SRAM • Provides design criteria for nanoscale FinFET and nanoscale thin- and thick-BOX planar FD/SOI MOSFET to help reduce technology development time • Projects potential nanoscale UTB CMOS performances • Contains end-of-chapter exercises. For professional engineers in the CMOS IC field who need to know about optimal non-classical device design and integration, this is a must-have resource.
Cinnamoyl Derivatives of 7α-Aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7α-Aminomethyl-6,14-endo-ethanotetrahydrooripavine and Related Opioid Ligands (2007)

A new series of ligands has been synthesized where the cinnamoyl group of the 14-cinnamoylamino morphinones has been introduced to the 7alpha-substituent of the 6,14-bridged oripavine series. In vitro the compounds were mostly low efficacy partial agonists or antagonists with some selectivity for the mu opioid receptor, with evidence of micro efficacy in vivo. The similarity in SAR between these 6,14-bridged oripavines and the 14-cinnamoylamino series suggests a similar mode of interaction with the micro opioid receptor.
How to control the stoichiometry of cadmium telluride thin film for photovoltaic applications (2017)

In this study, Bube's growth model for a cadmium telluride (CdTe) polycrystalline thin film was re-examined with a view of avoiding his assumptions that neglect the vapor pressures of Cd and Te2 near the film. We proposed a new thermodynamic growth model based on the fact that there is an experimentally verified characteristic ratio (α) of equilibrium partial pressures PCd/2PTe2 that depends on the temperature T and CdTe stoichiometry. By writing PCd(0)=2α(0)PTe2(0) and PCd(h)=2α(h)PTe2(h), where α(0) is determined by source stoichiometry, we can solve the equations for α(h) and thereby determine the stoichiometry of the CdTe thin film grown under physical vapor deposition (PVD) conditions. Simulation was performed to predict the stoichiometry of the CdTe thin film as a function of source stoichiometry for various source-film temperature combinations. The results show that for a typical CdTe PVD process with Tsource&amp;gt;Tthin film: (1) stable deposition, without a non-stoichiometric composition shift, can be achieved at congruent-growth stoichiometry; (2) any stoichiometric deviation from the congruent sublimation point becomes more substantial (in the same direction) in the thin film than in the source; and (3) larger ΔT between the source and the thin film results in a more composition shift.
Supplementary Data from Alpha-1 Adrenergic Antagonists Sensitize Neuroblastoma to Therapeutic Differentiation (2023)

&lt;p&gt;Supplementary Figures from S1 to S23 and Supplementary tables from S1 to S3&lt;/p&gt;
The Neck and Posterior Fossa Combined Penetrating Injury: A Case Report (2016)

Here we report a case of penetrating neck injury to the posterior fossa that was shown, using high-resolution computed tomography (HRCT) and digital subtraction angiography (DSA), to involve no vascular injury. A 54-year-old man was brought to the emergency department after a penetrating injury to the left side of the posterior neck and occipital area with a knife. He was in an intoxicated state and could not communicate readily. On initial examination, his vital signs were stable and there was no active bleeding from the penetrating site. Because of concern about possible injury to adjacent vessels, we performed HRCT and DSA sequentially, and identified that the blade of the knife had just missed the arteriovenous structures in the neck and posterior fossa. The patient was then transferred to the operating room where the knife was gently removed. Further careful exploration was performed through the penetrating wound, and we confirmed that there were no major injuries to the vessels and neural structures. Postoperative computed tomography revealed that there was minimal hemorrhage in the left cerebellar hemisphere. The patient made a full recovery without any neurologic deficit. In this case, HRCT is a suitable tool for the initial overall evaluation. For the evaluation of vascular injury, DSA can be a specific and accurate tool. Mandatory exploration widely used for penetrating injuries. After careful preoperative evaluation and interpretation, simple withdrawal of material can be a choice of treatment.
A Lateral Flow Assay for the Detection of Leptospira lipL32 Gene Using CRISPR Technology (2023)

The clinical manifestation of leptospirosis is often misdiagnosed as other febrile illnesses such as dengue. Therefore, there is an urgent need for a precise diagnostic tool at the field level to detect the pathogenic <i>Leptospira lipL32</i> gene at the molecular level for prompt therapeutic decisions. Quantitative polymerase chain reaction (qPCR) is widely used as the primary diagnostic tool, but its applicability is limited by high equipment cost and the lack of availability in every hospital, especially in rural areas where leptospirosis mainly occurs. Here, we report the development of a CRISPR dFnCas9-based quantitative lateral flow immunoassay to detect the <i>lipL32</i> gene. The developed assay showed superior performance regarding the lowest detectable limit of 1 fg/mL. The test is highly sensitive and selective, showing that leptospirosis diagnosis can be achieved with a low-cost lateral flow device.
Supplementary Movie from Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition (2023)

&lt;p&gt;Supplementary Movie. Three-dimensional projection of confocal z-stack immunofluorescent images of SMA&lt;sup&gt;+&lt;/sup&gt;/ZsGreen&lt;sup&gt;+&lt;/sup&gt; cells in &lt;i&gt;ZsGreen&lt;sup&gt;Cdh5-Cre&lt;/sup&gt;&lt;/i&gt; mouse mammary tumors. Orthotopic E0771 tumors from the &lt;i&gt;ZsGreen&lt;sup&gt;Cdh5-Cre&lt;/sup&gt;&lt;/i&gt; mice with vessels endogenously labeled with ZsGreen (green) were immunostained with SMA (red).&lt;/p&gt;
Reduced Chronic Lymphocyte Activation following Interferon Alpha Blockade during the Acute Phase of Simian Immunodeficiency Virus Infection in Rhesus Macaques (2018)

Pathogenic human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) infection of humans and rhesus macaques (RMs) induces persistently high production of type I interferon (IFN-I), which is thought to contribute to disease progression. To elucidate the specific role of interferon alpha (IFN-α) in SIV pathogenesis, 12 RMs were treated prior to intravenous (i.v.) SIV<sub>mac239</sub> infection with a high or a low dose of an antibody (AGS-009) that neutralizes most IFN-α subtypes and were compared with six mock-infused, SIV-infected controls. Plasma viremia was measured postinfection to assess the effect of IFN-α blockade on virus replication, and peripheral blood and lymphoid tissue samples were analyzed by immunophenotypic staining. Consistent with the known antiviral effect of IFN-I, high-dose AGS-009 treatment induced a modest increase in acute-phase viral loads versus controls. Four out of 6 RMs receiving a high dose of AGS-009 also experienced an early decline in CD4<sup>+</sup> T cell counts that was associated with progression to AIDS. Interestingly, 50% of the animals treated with AGS-009 (6/12) developed AIDS within 1 year of infection compared with 17% (1/6) of untreated controls. Finally, blockade of IFN-α decreased the levels of activated CD4<sup>+</sup> and CD8<sup>+</sup> T cells, as well as B cells, as measured by PD-1 and/or Ki67 expression. The lower levels of activated lymphocytes in IFN-α-blockaded animals supports the hypothesis that IFN-α signaling contributes to lymphocyte activation during SIV infection and suggests that this signaling pathway is involved in controlling virus replication during acute infection. The potential anti-inflammatory effect of IFN-α blockade should be explored as a strategy to reduce immune activation in HIV-infected individuals.<b>IMPORTANCE</b> Interferon alpha (IFN-α) is a member of a family of molecules (type I interferons) that prevent or limit virus infections in mammals. However, IFN-α production may contribute to the chronic immune activation that is thought to be the primary cause of immune decline and AIDS in HIV-infected patients. The study presented here attempts to understand the contribution of IFN-α to the natural history and progression of SIV infection of rhesus macaques, the primary nonhuman primate model system for testing hypotheses about HIV infection in humans. Here, we show that blockade of IFN-α action promotes lower chronic immune activation but higher early viral loads, with a trend toward faster disease progression. This study has significant implications for new treatments designed to impact the type I interferon system.
Safety Factor and Inverse Reliability Measures (2004)

Probability performance measure and probability sufficiency factor are two inverse reliability measures that have gained importance as alternate measures of safety. Inverse measures have several advantages, including improving accuracy in response surface approximations, computational efficiency, and allowing easy estimates of resources needed for achieving the target safety levels. This paper establishes the relationship between the two inverse measures, and describes their advantages compared to the direct measures of probability and reliability index. Methods to compute the inverse measures are also described. Reliability based design optimization with inverse measure is demonstrated with a beam design example.
Single-frequency Yb-doped photonic crystal fiber amplifier with 800W output power (2014)

A novel acoustic and gain tailored Yb-doped photonic crystal fiber is used to demonstrate over 800 W single-frequency output power with excellent beam quality at 1064 nm. The large mode area fiber core is composed of 7 individually doped segments arranged to create three distinct acoustic regions and preferential gain overlap with the fundamental optical mode. This design leads to suppression of both stimulated Brillouin scattering and modal instability. To the best of our knowledge, the output power represents the highest power ever reported from a near diffractionlimited single-frequency fiber laser. Furthermore, we show that by using a broadband seed, 1.22 kW of output power is obtained without the onset of the modal instability.
High oxygen and carbon contents in GaAs epilayers grown below a critical substrate temperature by molecular beam epitaxy (1996)

By quantitative secondary ion mass spectroscopy (SIMS) analyses, oxygen and carbon contents in GaAs epitaxial layers grown by molecular beam epitaxy (MBE) were found to increase significantly when the growth temperature was reduced below a critical value at about 450 °C. The concentrations of oxygen and carbon in GaAs epilayers grown below the critical temperature were about 4×1017 cm−3 and 3×1016 cm−3, respectively. Meanwhile, impurity accumulation during growth interruption became faster resulting in even higher interfacial impurity concentrations. Oxygen and carbon will affect the electrical properties of the GaAs epilayers, especially those grown between 350 °C and 450 °C where defects related to excess As may not be dominating.
High-current Y-Ba-Cu-O coated conductor using metal organic chemical-vapor deposition and ion-beam-assisted deposition (2016)

Abstract--YBa2Cu3Ox (YBCO) films have been deposited on buffered metal substrates by metal organic chemical-vapor deposition (MOCVD). Nickel alloy substrates with biaxially-textured yttria-stabilized zirconia (YSZ) buffer layers deposited by ion-beam-assisted deposition (IBAD) were used. A liquid-static precursor delivery system was designed, constructed, and used in the MOCVD facility at Intermagnetics for the reported work. At 77 K, under self-field conditions, we achieved a critical current (Ic) of 97.5 A in YBCO film grown by MOCVD on an IBAD substrate. This Ic corresponds to a critical current density of 1.3 MA/cm2 and 130 A/cm width of tape. Index Terms--MOCVD, IBAD, current density, biaxial-texture I.
Mandatory Arbitration of Statutory Employment Disputes: A Public Policy Issue in Need of a Legislative Solution (2012)

15. Eric K Yamamoto has noted the paucity of literature referencing racial minorities, women and the poor
Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease (2016)

For the first time, we identified serum-circulating miRNAs that predict the switch from favorable to HR-NB and, further imply that these miRNAs could play a functional role in tumor progression.
Figure S5 from Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer (2023)

&lt;p&gt;Figure S5. Effects of ABT-263 and AZD-1775 combinations on SCNPC and ARPC cell lines.&lt;/p&gt;
Application of signal processing techniques for estimating regions of copy number variations in human meningioma DNA (2009)

We applied mode-decomposition and matched-filtering, both signal processing techniques used to increase the signal-to-noise ratio (SNR), to array CGH data of human meningioma DNA, in order to extract genomic regions of copy-number changes potentially associated with tumor progression. DNA segments from different chromosomes were decomposed into a small number of dominant components (modes), and low-amplitude modes were eliminated. The SNR of the entire segment was increased and it was possible to identify local changes in the data spatial structure, previously indistinguishable due to noise. We applied matched-filtering to the mode-reduced signals, using a normal DNA sequences (averaged over 50 healthy donors) as the template. The residual signals from this process were analyzed to identify disease-related copy number changes. We were able to identify distinct local changes at different chromosomes in patients with recurrent versus primary meningiomas.
Compensation of pulse-distortion in saturated laser amplifiers (2008)

We derive an expression describing pre-compensation of pulse-distortion due to saturation effects in short pulse laser-amplifiers. The analytical solution determines the optimum input pulse-shape required to obtain any arbitrary target pulse-shape at the output of the saturated laser-amplifier. The relation is experimentally verified using an all-fiber amplifier chain that is seeded by a directly modulated laser-diode. The method will prove useful in applications of high power, high energy laser-amplifier systems that need particular pulse-shapes to be efficient, e.g. micromachining and scientific laser-matter-interactions.
Spiroplasma mirum, a New Species from the Rabbit Tick (Haemaphysalis leporispalustris) (1982)

Three spiroplasma strains recovered from rabbit ticks (Haemaphysalis leporispalustris) in Georgia and Maryland were found to be similar in biochemical, serological, and pathological properties. The organisms grew at temperatures of 20 to 37°C, required cholesterol for growth, fermented glucose, hydrolyzed arginine, and produced a film and spot reaction. The three spiroplasma strains were serologically distinct from the one established species (Spiroplasma citri) in the genus and from all other unclassified spiroplasma serogroups presently known. On the basis of these findings and other morphological, biological, and serological properties of the organism, it is proposed that spiroplasma strains with these characteristics be classified as a new species, Spiroplasma mirum. Strain SMCA (ATCC 29335) is the type strain.
Use of ifosfamide, carboplatin, and etoposide chemotherapy in choroid plexus carcinoma (2010)

In this experience, second surgery following neoadjuvant ICE chemotherapy led to a high rate of complete or near-complete resection. Chemotherapy appears to facilitate second-look surgery, in particular through a reduction of intraoperative blood loss. Despite radiation avoidance, the majority of survivors experienced significant neurocognitive impairment.
Determination of Trace Amount of Linear Alkylbenzene Sulfonates in River Water (1992)

An improved and accurate method for the determination of linear alkybenzene sulfonate(LAS) in river water is described by using gas chromatography and GC/MS. The gas chromatograph equipped with BP-5 capillary column was satisfactory for isolation of the homologues and isomers of LAS in river water. Four LAS homologues, , , , alkyl chains were determined in Jungrang stream, Jinwi stream and down stream of Han river tributary. Especially , , and , of LAS were identified by mass chromatogram. Different composition of LAS in standard and river water expressed the distribution and fate of LAS in river water. The remarkable reduced content of and in river water implied that the biodegradation of LAS more easily occured in longer alkylchain one. This method would be applicable for determination of LAS in water with high resolution and sensitivity.
Joint Source-Channel Decoding of Variable Length Codes for Convolutional Codes and Turbo Codes (2005)

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