gebhart/patrepeval huggingface dataset:
Influence of dietary restriction and aging on natural killer cell activity in mice. (1983)

Natural killer cells (NK) are believed to defend against tumor growth. Because rodents subjected to dietary restriction without malnutrition live longer and develop spontaneous tumors less often or later in life than unrestricted controls, we measured NK activity in restricted and in unrestricted mice. An age-related decline in NK responses to YAC-1 tumor target cells was detected in both groups. NK responses for control mice were highest in 2- to 3-mo-old mice, sharply reduced in middle-age mice (14 to 15 mo), and slightly reduced further in old mice (30 to 33 mo). At all ages the response of restricted mice was less than that of controls. However, after injection with Poly I:C (which increases NK activity), old restricted mice showed NK cytolysis not different from young mice on either diet, and substantially higher responses than old unrestricted mice. In addition, restricted mice showed increased in vitro generation of cytotoxic T lymphocytes (CTL) to YAC-1 and P815 compared with age-matched controls. Restricted mice may better resist cancer via an NK system very responsive to induction signals coupled with a CTL system more effective than that of unrestricted controls.
Epoxy resins from novel monomers with a bis‐(9,10‐dihydro‐9‐oxa‐10‐oxide‐10‐phosphaphenanthrene‐10‐yl‐) substituent (2001)

Abstract A new diepoxide and a new diamine, both bearing bis‐(9,10‐dihydro‐9‐oxa‐10‐oxide‐10‐phosphaphenanthrene‐10‐yl‐)‐substituted methylene linkages, were prepared through the reaction of 9,10‐dihydro‐oxa‐10‐phosphaphenanthrene‐10‐oxide with benzophenone derivatives via a simple addition reaction followed by a dehydration reaction. These two compounds were used as monomers for preparing cured epoxy resins with high phosphorus contents. The resultant epoxy resins showed high glass‐transition temperatures (between 131 and 196 °C). All of the cured epoxy resins exhibited high thermal stability, with 5% weight loss temperatures over 316 °C, and excellent flame retardancy, with limited oxygen index values of 37–50. © 2001 John Wiley &amp; Sons, Inc. J Polym Sci Part A: Polym Chem 40: 359–368, 2002
Interaction of SR-4233 with hyperthermia and radiation in the FSaIIC murine fibrosarcoma tumor system in vitro and in vivo. (1990)

The effects of SR-4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide), a hypoxic cell cytotoxic agent, were assayed against the FSaIIC murine fibrosarcoma in vitro and in vivo alone and in conjunction with hyperthermia and radiation. In vitro, a concentration of 500 microM of SR-4233 upon exposure of the cells for 1 h decreased the survival of hypoxic cells by about 1 log more than euoxic cells at 37 degrees C and pH 7.40. At the same concentration at pH 6.45, this difference in cytotoxicity increased to about 3 logs. In conjunction with 42 or 43 degrees C hyperthermia at pH 7.40, the killing of both euoxic and hypoxic cells was markedly increased (hypoxic greater than oxic), and the effect of hyperthermia on SR-4233 cytotoxicity was further increased at pH 6.45. SR-4233 proved to be an effective radiosensitizer of hypoxic cells in vitro, producing an enhancement ratio of 2.6 +/- 0.2 at pH 7.40 and 2.7 +/- 0.2 at pH 6.45. In vivo, however, SR-4233 (50 mg/kg) used with single dose radiation (10, 20, or 30 Gy) did not alter the slope of the radiation dose-dependent tumor growth delay curve but did produce a significant additive increase in tumor growth delay. Local hyperthermia (43 degrees C, 30 min) plus SR-4233 (30 mg/kg) produced a tumor growth delay of 9.1 +/- 2.2 days, whereas SR-4233 alone caused a tumor growth delay of only 1.7 +/- 0.9 days and the hyperthermia, only 1.4 +/- 0.7 days. The tumor growth delay increased to 28.2 +/- 4.4 days with the addition of daily radiation (3 Gy for 5 days) to SR-4233 and hyperthermia given on treatment day 1 only. Hoechst 33342 dye-selected tumor subpopulation analysis at 24 h following treatment demonstrated that SR-4233 (30 mg/kg) was more toxic to dim (presumably hypoxic) cells by about 1.8-fold. The addition of hyperthermia to treatment with SR-4233 increased the killing of dim cells by about 5-fold but of bright cells by only 2-fold. Trimodality treatment with SR-4233, hyperthermia, and radiation increased the killing of bright cells by about 6.5-fold and of dim cells by about 16.5-fold as compared with radiation alone. These results indicate that SR-4233 might be used quite effectively with radiation and/or hyperthermia to treat tumors with significant hypoxic subpopulations.
Utilization of Markov Model and Non-Parametric Belief Propagation for Activity-Based Indoor Mobility Prediction in Wireless Networks (2011)

A foremost objective in wireless networks is to facilitate the communication of mobile users and the widespread tracking and prediction of their mobility regardless of their point of attachment to the network. In indoor environments the effective users' motion prediction system and wireless localization technology play an important role in all aspects of people's daily lives, including e.g. living assistant, navigation, emergency detection, surveillance/tracking of target-of-interest, evacuation purposes, and many other location-based services. Prediction techniques that are currently used do not consider the motivation behind the movement of mobile nodes and incur huge overheads to manage and manipulate the information required to make predictions. In this paper we propose an activity-based continuous-time Markov model to define and predict the human movement patterns. Then we demonstrate the utility of Nonparametric Belief Propagation (NBP) technique in particle filtering, for both estimating the node locations and representing location uncertainties, and for prediction of the areas that would be visited and those that would not in the future. NBP method admits a wide variety of statistical models, and can represent multi-modal uncertainty. This prediction system may be used as an additional input into intelligent building automation systems.
Iron-containing N-doped carbon electrocatalysts for the cogeneration of hydroxylamine and electricity in a H2–NO fuel cell (2015)

Iron-containing N-doped carbon materials are active electrocatalysts for the cogeneration of hydroxylamine and electricity in a H<sub>2</sub>–NO fuel cell, which is a promising alternative to the present industrial synthesis.
Hemodynamic, Hormone, and Urinary Effects of Adrenomedullin Infusion in Essential Hypertension (2000)

We examined the effects of the vasodilator peptide adrenomedullin (AM) infused intravenously into subjects with essential hypertension. Eight men 39 to 58 years old with uncomplicated hypertension (147/96+/-5/3 mm Hg at baseline) were studied in a placebo-controlled, crossover design. Each subject received intravenous AM in a low and a high dose (2.9 and 5.8 pmol. kg(-1). min(-1) for 2 hours each) or vehicle-control (Hemaccel) infusion in a random order on day 4 of a controlled metabolic diet (80 mmol/d Na(+), 100 mmol/d K(+)). Plasma AM reached pathophysiological levels during infusion (18+/-4 pmol/L in low dose, 34+/-9 pmol/L in high dose) with a concurrent rise in plasma cAMP (+8.4+/-1.2 pmol/L, P:<0. 05 compared with control). Compared with control, high-dose AM increased peak heart rate (+17.8+/-2.3 bpm, P<0.01), lowered systolic (-24.6+/-0.9 mm Hg; P<0.01) and diastolic (-21.9+/-1.4 mm Hg; P<0.01) blood pressure, and increased cardiac output (+1.0+/-0. 1 L/min in low dose, +2.9+/-0.2 L/min in high dose; P<0.01 for both). Despite a rise in plasma renin activity during high dose (P<0.05), aldosterone levels did not alter. Plasma norepinephrine levels increased 1295+/-222 pmol/L (P<0.001) and epinephrine increased 74+/-15 pmol/L (P<0.05) with high-dose AM compared with control. AM had no significant effect on urine volume and sodium excretion. In subjects with essential hypertension, the intravenous infusion of AM to achieve pathophysiological levels produced significant falls in arterial pressure, increased heart rate and cardiac output, and stimulated the sympathetic system and renin release without concurrent increase in aldosterone. Urinary parameters were unaltered. Although AM has potent hemodynamic and neurohumoral effects in subjects with essential hypertension, the threshold for urinary actions is set higher.
Electrical and structural properties of Ti/Al‐based contacts on AlGaN/GaN heterostructures with different quality (2015)

In this work, the electrical and structural properties of Ti/Al contacts on AlGaN/GaN heterostructures with a different crystalline quality were investigated. In particular, the sample with a lower defects density required a higher temperature (800 °C) to obtain Ohmic contacts, while the more defective sample showed Ohmic behaviour at lower annealing temperature (500 °C). The susceptibility to oxidation of the metal stack upon annealing has been monitored by chemical analyses. Moreover, the temperature dependence of the contact resistance of the Ti/Al annealed contacts revealed that the interface current transport mechanism depends on the material quality. These results were attributed to the presence of V‐shaped defect close to the surface of the AlGaN barrier layer. A nanoscale electrical analysis demonstrated a preferential current conduction through these defects, which indeed plays a relevant role for the formation of the Ohmic contact.
4π Compton imaging using a 3-D position-sensitive CdZnTe detector via weighted list-mode maximum likelihood (2004)

In this work we describe a 4/spl pi/ Compton imager composed of a single 15 mm /spl times/ 15 mm /spl times/ 10 mm CdZnTe detector. The anode is pixellated into an 11 /spl times/ 11 array to provide position sensitivity in two dimensions. The third coordinate is determined from the observed timing of signals in the detector. The position resolution is approximately 1.2 mm in each dimension. The energy resolution is about 2% for two-pixel events at 662 keV. Images are reconstructed via list-mode maximum likelihood (ML). A new weighting method for ML reconstruction is proposed in which the contributions of small-uncertainty sequences are enhanced relative to sequences with large uncertainties. The new reconstruction method is compared with traditional ML techniques for measured imaging data.
Identification of Myelin Transcription Factor 1 (MyT1) as a Subunit of the Neural Cell Type-specific Lysine-specific Demethylase 1 (LSD1) Complex (2014)

Regulation of spatiotemporal gene expression in higher eukaryotic cells is critical for the precise and orderly development of undifferentiated progenitors into committed cell types of the adult. It is well known that dynamic epigenomic regulation (including chromatin remodeling and histone modifications by transcriptional coregulator complexes) is involved in transcriptional regulation. Precisely how these coregulator complexes exert their cell type and developing stage-specific activity is largely unknown. In this study we aimed to isolate the histone demethylase lysine-specific demethylase 1 (LSD1) complex from neural cells by biochemical purification. In so doing, we identified myelin transcription factor 1 (MyT1) as a novel LSD1 complex component. MyT1 is a neural cell-specific zinc finger factor, and it forms a stable multiprotein complex with LSD1 through direct interaction. Target gene analysis using microarray and ChIP assays revealed that the Pten gene was directly regulated by the LSD1-MyT1 complex. Knockdown of either LSD1 or MyT1 derepressed the expression of endogenous target genes and inhibited cell proliferation of a neuroblastoma cell line, Neuro2a. We propose that formation of tissue-specific combinations of coregulator complexes is a critical mechanism for tissue-specific transcriptional regulation.
Metal Organic Framework Derived Core–Shell Structured Co9S8@N–C@MoS2 Nanocubes for Supercapacitor (2018)

Transition metal sulfides with designed nanostructure have attracted significant research interest as electrode materials for supercapacitors. In this work, core–shell structured Co9S8@N–C@MoS2 nanocubes have been successfully fabricated through a sulfuration process based on ZIF-67 precursor. Due to improved electrical conductivity and large surface area, Co9S8@N–C@MoS2 nanocubes with core–shell heterostructure exhibit better electrochemical performance in supercapacitors compared with Co9S8. Moreover, the morphology of core–shell structured Co9S8@N–C@MoS2 nanocubes can be well-adjusted by tuning the ratio between Co9S8 and MoS2. The homogeneous core–shell structured Co9S8@N–C@MoS2 nanocubes (S-3) can be obtained with the mass ratio of Na2MoO4·2H2O and CH4N2S at 1:2. And the obtained core–shell structured S-3 delivers a high specific capacitance of 410.0 F g–1 at the current density of 10.0 A g–1 after 20000 cycles with excellent cycling stability (101.7% of the initial value). The excellent electrochemical property is mainly due to the unique structure which induces synergistic effects between Co9S8 and MoS2.
Robot-Assisted Radical Cystectomy with Total Intracorporeal Urinary Diversion: Comparative Analysis with Extracorporeal Urinary Diversion (2016)

From our experience, the results show that ICUD after RARC can be successful, with the benefits of decreased blood loss and lower transfusion and complication rates than ECUD. A larger series and long-term follow-up data will be necessary to support our results.
Dosimetry of High Dose Skeletal Targeted Radiotherapy (STR) with 166 Ho-DOTMP (2003)

A study was undertaken to determine the maximum tolerated dose of (166)Ho-DOTMP that could be administered safely, without negatively impacting marrow re-engraftment, in patients with multiple myeloma treated with melphalan prior to transplant. Ho-166 DOTMP is a tetraphosphonate that localizes rapidly to bone surface. The Ho-166 physical half-life is 26.8 hr and the maximum beta energy is 1.8 MeV. Standard dosimetry models were adapted for radiation absorbed dose estimates using data obtained from whole body counting of the low abundance photons emitted by (166)Ho. Eighty-three patients received high dose (166)Ho-DOTMP followed by melphalan and transplant of peripheral blood stem cells. Twenty-five patients also received 8 Gy total body radiation (TBI). Dosages administered ranged from 460 to 4476 mCi (166)Ho-DOTMP. Marrow dose was derived using the assumption that all radioactivity not excreted by 20 hours was localized to the bone surfaces, and applying the Eckerman bone and marrow dose model to the calculated bone residence times. The dosimetry of the urinary bladder and kidneys was important because of the rapid excretion of the non-targeted radioactivity via the urinary pathway. The dynamic bladder model was used for bladder wall surface dose, and the ICRP 53 kinetic model was used to model kidney kinetics with an additional blood component included. Marrow doses ranged from 13 to 59 Gy and successful hematapoietic recovery occurred. Bladder doses ranged from 4.7 to 157 Gy. Hemorrhagic cystitis occurred in some patients who received more than 40 Gy to the bladder wall surface. Bladder irrigation was successful in protecting patients from bladder toxicity. Kidney doses ranged from 0.5-7.9 Gy. Kidney toxicity in the form of thrombotic microangiopathy with renal dysfunction was observed, with the severity being related to Ho-166-DOTMP radiation dose and probably the dose rate as well. In a future trial, kidney dosimetry will be assessed using early serial gamma camera imaging and modifications will be implemented to reduce renal toxicity.
High-Performance Energy Selective Surface Based on the Double-Resonance Concept (2021)

In this article, a high-performance energy selective surface (ESS) is proposed based on a double-resonance concept, which has a nonlinear transmission response for high-power electromagnetic protection. With well-designed grid and cross patterns as well as properly chosen p-i-n diodes, bandpass and band-stop resonances are excited by the ESS at the same frequency under low and high incident power levels, respectively, resulting in low insertion loss (IL) and high shielding effectiveness (SE) of the ESS. Two samples of single-layer and double-layer ESSs operating at 3 GHz are designed to demonstrate the double-resonance concept. By utilizing a double-layer structure, a second-order band-stop resonance is produced to achieve a broader bandwidth with high SE in comparison with the single-layer ESS. Equivalent circuit models are employed to explain how the double resonances are produced and a wide bandwidth of high SE is obtained. Field circuit cosimulation is conducted to estimate the nonlinear performance of the ESS designs. Moreover, the ESS designs are measured in a rectangular waveguide setup. Good agreement is observed between the simulation and measurement. Simulated and measured results demonstrate that low IL less than 1 dB and high SE larger than 24 dB can be obtained under low and high incident power levels, respectively.
Abstract 206: Depletion of ovarian cancer initiating cells by a monoclonal antibody against ROR1 (2014)

Abstract ROR1 is a type I orphan-receptor tyrosine-kinase-like surface protein that is expressed during embryogenesis and by various cancer cells, but not on normal adult tissues. Its expression is associated with less-well-differentiated tumors with high metastatic potential (Zhang et al Am J Pathol, 2012, PMCID 3509760; Cui et al Cancer Res, 2013, PMCID 3832210). We evaluated the expression of ROR1 in human ovarian cancers and examined the activity of newly developed anti-ROR1 monoclonal antibodies (mAbs, e.g. UC-961) found to have activity against ROR1-expressing breast cancer cell lines and B-cell leukemias. We examined primary human ovarian cancer cells engrafted into immune-deficient NOD/scid mice (PDX) for human ROR1 expression and for phenotypic and functional characteristics of cancer-stem cells (CSC). In each tumor specimen, we observed different proportions of ROR1-expressing cells. Expression of ROR1 associated with markers of CSC, such as aldehyde dehydrogenase 1 (ALDH1). Moreover, the ROR1+ cells from any given PDX sample had a greater capacity to form spheroids in vitro and to engraft immune-deficient mice than did ROR1-negative cells isolated from the same tumor population. Treatment of ovarian cancer cells with the anti-ROR1 mAb UC-961, but not control IgG, reproducibly impaired their ability to form spheroids, and to engraft into immune-deficient NOD/scid mice. In subsequent studies, we isolated ALDH1+ and ALDH1- cells from the same PDX samples. As noted in prior studies (Ginestier et al Cell Stem Cell, 2007, PMCID 2423808), ALDH1+ cells engrafted more effectively than ALDH1- cells. However, treatment of ovarian cancer cells with the UC-961 mAb abrogated the difference in the capacity of ALDH1+ versus ALDH1- cells to engraft NOD/scid mice. Analysis of the few tumors that did develop in mice engrafted with UC-961-treated, but not control IgG-treated, tumor cells revealed that, compared to the original PDX tumor sample, these tumors had lower proportions of ALDH1+ cells and reduced expression of the polycomb ring finger oncogene, BMI1, and changed the expression level of markers associated with the epithelial-mesenchymal transition (e.g. E-Cadherin and vimentin). Collectively, these studies indicate that expression of ROR1 is associated with CSC and that anti-ROR1 mAbs such as UC-961 can interfere with CSC function and self-renewal, suggesting that such biologics may be useful in the treatment of patients with ovarian cancer. Citation Format: Suping Zhang, Bing Cui, Hsien Lai, Grace Liu, Christina Wu, George Widhopf, Rongrong Wu, Fitzgerlad Lao, Richard Schwab, Dennis Carson, Thomas J. Kipps. Depletion of ovarian cancer initiating cells by a monoclonal antibody against ROR1. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 206. doi:10.1158/1538-7445.AM2014-206
Glycopyrrolate Treatment of Chronic Drooling (1996)

Glycopyrrolate therapy safely and effectively decreased but rarely abolished drooling in patients with cerebral palsy and related neurodevelopmental disabilities. The dose range was surprisingly broad. Side effects, although generally minor and predictable, often led to discontinuation of drug therapy.
A Broadband Dual-Polarized Omnidirectional Antenna for Base Stations (2012)

A broadband vertically/horizontally dual-polarized omnidirectional antenna is proposed for mobile communications. The dual-polarized antenna is a combination of a modified low-profile monopole for vertical polarization (VP) and a circular planar loop for horizontal polarization (HP). The modified low-profile monopole is a circular folded patch shorted by four tubes while the circular loop consists of four half-wavelength arc dipoles. The dual-polarized omnidirectional antenna achieves a bandwidth of ~ 25% (1.7-2.2 GHz) with an isolation of around 40 dB. The gain variations in the horizontal plane are less than 2.5 dB for VP and 1.5 dB for HP. An eight-element dual-polarized antenna array is developed for base station applications. The antenna gains of the array for both VP and HP are ~ 8 dBi with a difference of less than 1 dB. The beamwidths in the vertical plane are 9±1 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> for VP and 9±1.5 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> for HP. The cross-polarization levels in the horizontal plane for both VP and HP are lower than -20 dB.
High Expression of Membrane Cofactor Protein of Complement (CD46) in Human Leukaemia Cell Lines: Implication of an Alternatively Spliced Form Containing the STA Domain in CD46 Up‐Regulation (1995)

Human membrane cofactor protein (MCP, CD46) is a receptor for the measles virus and serves as a complement regulator which protects host cells from autologous complement attack. MCP is highly polymorphic due to a variety of mRNA splice products. The levels of MCP expression on T and myeloid cell lines are usually two-eightfold higher than those on their normal counterparts, whereas Burkitt's lymphoma B cell lines express less MCP than B cell lineages carrying no EB virus. The molecule has a Ser/Thr-rich (ST) domain adjacent to the functional domain, namely short consensus repeats (SCR). The ST domain and a cytoplasmic tail (CYT) contribute to the MCP polymorphism. The ST domain is encoded by three exons (A, B and C) and major ST isoforms are STABC, STBC and STC. The authors investigated the relationship between the expression levels and isoform usage of MCP by flow cytometry using specific antibodies against STA and STC, by reverse transcriptase-polymerase chain reaction (RT-PCR) with size markers for each splice variant, and by RT-PCR/Southern blotting using a specific probe for STA. The results were (1) the profiles of mean shifts of myeloid and T cell lines were STC < STA on flow cytometry while those of B cell lines and normal blood cells were STA < STC; (2) all cell lines tested by RT-PCR expressed the messages for the isoforms STBC/CYT1, STC/CYT1, STBC/CYT2, and STC/CYT2. The band for STABC/CYT2 overlapped that for STC/CYT1, and the band for STABC/CYT1 was marginal in all cell lines examined; (3) semi-quantitative analysis of the STABC isoforms by Southern blotting indicated the presence of high levels of the STABC messages in myeloid and T-cell lines in comparison with B lymphoid cells and normal leucocytes. Thus, the quantity of MCP expressed parallels the STABC message level, which is up-regulated in T and myeloid leukaemia cell lines.