gebhart/patrepeval huggingface dataset:
Role Of Calcitonin Gene-Related Peptide and Substance P in Dahl-Salt Hypertension (2001)

Calcitonin gene-related peptide (CGRP) and substance P are known to play a counterregulatory role in acquired models of salt-dependent hypertension. In contrast, neuronal production of these peptides is decreased in the spontaneously hypertensive rat, which may contribute to the elevated blood pressure. To determine the role played by CGRP and substance P in Dahl-salt hypertension, 4- to 6-week-old male salt-resistant (DR) and salt-sensitive (DS) rats were divided into 4 groups (n=5/group) and pair-fed low-salt (0.2% NaCl) (DR/LS and DS/LS) and high-salt (8% NaCl) diets (DR/HS and DS/HS) for 3 weeks. After 3 weeks, all the rats had venous (for drug administration) and arterial (for blood pressure monitoring) catheters surgically implanted and were studied in the conscious and unrestrained state. Mean arterial pressure was significantly higher in the DS/HS rats animals (185.8+/-1.6 mm Hg, P<0.001). Intravenous administration of CGRP and SP receptor antagonists was without effect in any of the groups studied. CGRP and SP mRNA content from dorsal root ganglia were not significantly different between the groups. Whereas immunoreactive CGRP was decreased in the DS groups (DS/HS, 9.4+/-0.4 pg/microgram protein; DS/LS, 11.1+/-0.8 pg/microgram protein; P<0.01) compared with the DR groups (DR/HS, 13.9+/-0.6 pg/microgram protein; DR/LS, 14.6+/-0.6 pg/microgram protein), neuronal SP production was similar between all the groups. Thus, CGRP and substance P do not play a counterregulatory role in Dahl-salt hypertension. The decrease in neuronal CGRP expression in DS rats appears to be genetically determined as in SHR, however, and may contribute to the increase in blood pressure following salt-loading.
Besser ein magerer Vergleich als ein fetter Prozeß - Zur Güteverhandlung im Arbeitsgericht -. 8. Zwischen Neutralität und Parteilichkeit - oder: Der Umgang mit den rechtlichen Positionen der Streitparteien (1995)

Besser ein magerer Vergleich als ein fetter Prozeß - Zur Güteverhandlung im Arbeitsgericht -. 8. Zwischen Neutralität und Parteilichkeit - oder: Der Umgang mit den rechtlichen Positionen der Streitparteien was published in Band 1 Streit schlichten on page 242.
Assessment of genetically modified soybean MON 87708 × MON 89788 × A5547‐127, for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2016‐135) (2019)

Soybean MON 87708 × MON 89788 × A5547-127 (three-event stack soybean) was produced by conventional crossing to combine three single events: MON 87708, MON 89788 and A5547-127. The GMO Panel previously assessed the three single events and did not identify safety concerns. No new data on the single events, leading to modification of the original conclusions on their safety have been identified. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single soybean events and of the newly expressed proteins in the three-event stack soybean does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that the three-event stack soybean, as described in this application, is as safe as and nutritionally equivalent to its conventional counterpart and the non-GM reference varieties tested. The nutritional impact of food/feed derived from the three-event stack soybean is expected to be the same as that of food/feed derived from the conventional counterpart and non-GM reference varieties. In the case of accidental release of viable seeds of the three-event stack soybean into the environment, this would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of the three-event stack soybean. Post-market monitoring of food/feed is not considered necessary. The GMO Panel concludes that the three-event stack soybean is as safe as its conventional counterpart and the tested non-GM reference varieties with respect to potential effects on human and animal health and the environment.
Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation (2023)

Group A <i>Streptococcus</i> (GAS) infection is associated with multiple clinical sequelae, including different subtypes of psoriasis. Such post-streptococcal disorders have been long known but are largely unexplained. CD1a is expressed at constitutively high levels by Langerhans cells and presents lipid antigens to T cells, but the potential relevance to GAS infection has not been studied. Here, we investigated whether GAS-responsive CD1a-restricted T cells contribute to the pathogenesis of psoriasis. Healthy individuals had high frequencies of circulating and cutaneous GAS-responsive CD4<sup>+</sup> and CD8<sup>+</sup> T cells with rapid effector functions, including the production of interleukin-22 (IL-22). Human skin and blood single-cell CITE-seq analyses of IL-22-producing T cells showed a type 17 signature with proliferative potential, whereas IFN-γ-producing T cells displayed cytotoxic T lymphocyte characteristics. Furthermore, individuals with psoriasis had significantly higher frequencies of circulating GAS-reactive T cells, enriched for markers of activation, cytolytic potential, and tissue association. In addition to responding to GAS, subsets of expanded GAS-reactive T cell clones/lines were found to be autoreactive, which included the recognition of the self-lipid antigen lysophosphatidylcholine. CD8<sup>+</sup> T cell clones/lines produced cytolytic mediators and lysed infected CD1a-expressing cells. Furthermore, we established cutaneous models of GAS infection in a humanized CD1a transgenic mouse model and identified enhanced and prolonged local and systemic inflammation, with resolution through a psoriasis-like phenotype. Together, these findings link GAS infection to the CD1a pathway and show that GAS infection promotes the proliferation and activation of CD1a-autoreactive T cells, with relevance to post-streptococcal disease, including the pathogenesis and treatment of psoriasis.
A QoS Internet protocol scheduler on the IXP1200 network platform (2004)

In this paper we describe the implementation of a scheduler capable of Quality of Service (QoS) management on the Intel IXP 1200 network processor. First, the scheduling algorithm PTTSD is introduced at the abstract level showing its characteristics and complexity. Then, the IXP architecture is briefly described with the purpose of refining the PTTSD algorithm in order to provide a more efficient implementation. The refined PTTSD scheduler has been implemented on top of the reference design provided by Intel. The dependency of the adopted software architecture on the IXP network processor is analyzed and, finally, the implementation is described. A set of characterization tests is reported to demonstrate the efficiency of the implementation and the effectiveness of the Intel architecture to implement flexible QoS routers.
How to extract more information from a basic tensile test with the aid of FEA (2004)

status: Published
Experimental Verification of Simulation Based Yield Optimization for Power-On Reset Cells (2006)

Simulation based yield optimization is becoming an important solution for increasing robustness of analog IP blocks. This paper describes the yield optimization of a power-on reset cell as part of an analog IP library. Yield analysis of the initial design is performed and sensitivities with respect to process parameters are determined by Monte Carlo simulation. The input parameters used for the Monte Carlo simulation describe global and local variations of the semiconductor devices. The results of the yield analysis are used to determine a shift of production parameters enabling a yield enhancement of the initial design. A re-design using simulation-based design centering is performed resulting in a significant yield increase in consideration of the operating conditions. The optimization is based on an algorithm maximizing the worst-case-distance (sigma to target). The simulation results on improved production yield are verified by electrical test at wafer level for varying process conditions.
Quantification of Bacillus thuringiensis Insect Control Protein as Expressed in Transgenic Plants (1990)

Quantitative assays were developed to analyze gene products produced by transgenic plants that express Bacillus thuringiensis insect control proteins. Initially B. thuringiensis proteins were produced in plants at approximately 10,000 fold lower specific activities than the same proteins produced by microbial fermentations. Consequently, accurate and selective assays were developed to quantitate B. thuringiensis specific DNA (gene copy), mRNA and protein produced by insect tolerant transgenic plants. The 100 fold increase in B. thuringiensis protein expression achieved in plants, based on these analysis, enabled the production of transgenic plants that are protected against agronomically important insect pests.
Designing pipelined systems with a clock period approaching pipeline register delay (2005)

A novel mesochronous pipelining scheme is described in this paper. The clock period in the proposed pipeline scheme is determined by the pipeline stage with largest difference between its minimum and maximum delays. This is a significant performance gain compared to conventional pipeline scheme where clock period is determined by stage with the maximum delay. Also, in the proposed scheme the number of pipeline stages and pipeline registers is small and the clock distribution scheme is simpler. An 8 times 8-bit carry-save adder multiplier has been implemented in mesochronous pipeline architecture using modest TSMC 180 nm. The multiplier architecture and simulation results are described in detail in this paper. The pipelined multiplier is able to operate on a clock period of 350ps (2.86GHz), with fewer pipeline stages and pipeline registers
A sea change ahead for recreational water quality criteria (2008)

The United States Environmental Protection Agency is committed to developing new recreational water quality criteria for coastal waters by 2012 to provide increased protection to swimmers. We review the uncertainties and shortcomings of the current recreational water quality criteria, describe critical research needs for the development of new criteria, as well as recommend a path forward for new criteria development. We believe that among the most needed research needs are the completion of epidemiology studies in tropical waters and in waters adversely impacted by urban runoff and animal feces, as well as studies aimed to validate the use of models for indicator and pathogen concentration and health risk predictions.
Making Byzantine fault tolerant systems tolerate Byzantine faults (2009)

Abstract: This paper is motivated by a simple observation: although recently developed BFT state machine replication protocols are quite fast, they don’t actually tolerate Byznatine faults very well. In particular a single faulty client or server in PBFT, Q/U, HQ, and Zyzzyva can render each of these systems effectively unusable for many applications by reducing their throughput by two orders of magnitude or more, from thousands of requests per second to fewer than 10 requests per second. The problem comes not because these systems fail to meet the guarantees they promise, but because the guarantees they promise are insufficient for the high assurance systems for which BFT techniques are likely to be of most interest. In this paper, we describe Aardvark, a new BFT replication protocol that guarantees good performance during uncivil periods, when the network is reliable but when up to f servers and any number of clients are faulty. Aardvark gives up some performance compared to protocols that focus on optimizing for the best case, but Aardvark’s peak throughput of 40527 requests per second seems sufficient for many applications. Because Aardvark is less aggressively tuned for the fault free case, it is guaranteed to remain within a constant factor of 40527 when faults occur. We observe throughputs of between 11706and 40527for a broad range of injected faults. 1
A nanoscale bio-inspired light-harvesting system developed from self-assembled alkyl-functionalized metallochlorin nano-aggregates (2014)

Self-assembled supramolecular organization of nano-structured biomimetic light-harvesting modules inside solid-state nano-templates can be exploited to develop excellent light-harvesting materials for artificial photosynthetic devices. We present here a hybrid light-harvesting system mimicking the chlorosomal structures of the natural photosynthetic system using synthetic zinc chlorin units (ZnChl-C6, ZnChl-C12 and ZnChl-C18) that are self-aggregated inside the anodic aluminum oxide (AAO) nano-channel membranes. AAO nano-templates were modified with a TiO2 matrix and functionalized with long hydrophobic chains to facilitate the formation of supramolecular Zn-chlorin aggregates. The transparent Zn-chlorin nano-aggregates inside the alkyl-TiO2 modified AAO nano-channels have a diameter of ∼120 nm in a 60 μm length channel. UV-Vis studies and fluorescence emission spectra further confirm the formation of the supramolecular ZnChl aggregates from monomer molecules inside the alkyl-functionalized nano-channels. Our results prove that the novel and unique method can be used to produce efficient and stable light-harvesting assemblies for effective solar energy capture through transparent and stable nano-channel ceramic materials modified with bio-mimetic molecular self-assembled nano-aggregates.
COVID-19 detection from audio: seven grains of salt (2021)

Digital mass testing for COVID-19 via a mobile phone application could be made possible through machine learning and its ability to identify patterns in data. ] Many of these issues relate to a single question: are the learnt audio representations, which correlate with COVID-19 in the various collected datasets, truly audio biomarkers caused by COVID-19?
1946: Findings of Prostate Biopsy and Radical Prostatectomy Specimens in Patients with PSA Levels Lower and Higher than 4 NG/ML in the Extended Biopsy Era (2007)

You have accessJournal of UrologyModerated Poster 62, Wednesday, May 23,2007, 3:30 - 5:30 pm1 Apr 20071946: Findings of Prostate Biopsy and Radical Prostatectomy Specimens in Patients with PSA Levels Lower and Higher than 4 NG/ML in the Extended Biopsy Era Katia R.M. Leite, Miguel Srougi, Marcos F. Dall'Oglio, Alberto A. Antunes, Jose Cury, Adriana Sañudo, and Luiz Heraldo A. Camara-Lopes Katia R.M. LeiteKatia R.M. Leite More articles by this author , Miguel SrougiMiguel Srougi More articles by this author , Marcos F. Dall'OglioMarcos F. Dall'Oglio More articles by this author , Alberto A. AntunesAlberto A. Antunes More articles by this author , Jose CuryJose Cury More articles by this author , Adriana SañudoAdriana Sañudo More articles by this author , and Luiz Heraldo A. Camara-LopesLuiz Heraldo A. Camara-Lopes More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)32106-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1946: Findings of Prostate Biopsy and Radical Prostatectomy Specimens in Patients with PSA Levels Lower and Higher than 4 NG/ML in the Extended Biopsy Era." The Journal of Urology, 177(4S), p. 646 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 646 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Katia R.M. Leite More articles by this author Miguel Srougi More articles by this author Marcos F. Dall'Oglio More articles by this author Alberto A. Antunes More articles by this author Jose Cury More articles by this author Adriana Sañudo More articles by this author Luiz Heraldo A. Camara-Lopes More articles by this author Expand All Advertisement PDF downloadLoading ...
Effect of a Novel Long-Acting GLP-1/GIP/Glucagon Triple Agonist (HM15211) in a NASH and Fibrosis Animal Model (2018)

Nonalcoholic steatohepatitis (NASH), a potential consequence of NAFLD, may lead to end stage liver disease including cirrhosis and hepatocellular carcinoma. Despite its severity and prevalence, NASH currently lacks effective treatment. In this respect, we developed a novel long-acting, GLP-1/GIP/Glucagon triple agonist, HM15211. With a unique activity profile, HM15211 could provide synergistic benefits on body weight loss and lipid profile improvement while avoiding hyperglycemic risk. Previously, we showed that HM15211 exerts potent reductions in body weight and hepatic TG (triglycerides) in DIO mice, and showed a liver preferential distribution, suggesting HM15211 as a potential treatment for NASH. Here, we evaluated the effect of HM15211 in NASH and fibrosis using MCD-diet mice with various disease induction periods. In MCD-diet mice (6 weeks induction), HM15211 treatment led to significant decrease in hepatic TG (-82.6% vs. vehicle) and TBARS (oxidative stress marker, -60.7% vs. vehicle), which coincided with significant reduction in ALT and bilirubin. Time course MRI/MRS imaging further confirmed the progressive steatosis resolution by HM15211. Furthermore, histopathological analysis indicated that HM15211 significantly reduced hepatic inflammatory gene expression and NAFLD activity score (1.3 for HM15211, 3.4 for liraglutide, and 2.7 for vehicle). To further evaluate the therapeutic potential in fibrosis, MCD-diet mice was used for an extended period (10 weeks induction) to achieve overt liver fibrosis. In line with NASH improvement, HM15211 successfully resolved liver fibrosis as demonstrated in histological evaluation. Histological improvements were accompanied by a remarkable decrease in disease biomarkers including hepatic hydroxyproline. Based on these observations, HM15211 may offer a therapeutic potential for NASH and fibrosis as well as obesity. Disclosure I. Choi: Employee; Self; Hanmi Pharmaceutical. Stock/Shareholder; Self; Hanmi Pharmaceutical. J. Kim: Employee; Self; Hanmi Pharmaceutical. Stock/Shareholder; Self; Hanmi Pharmaceutical. J. Lee: Employee; Self; Hanmi Pharmaceutical. Stock/Shareholder; Self; Hanmi Pharmaceutical. E. Park: Employee; Self; Hanmi Pharmaceutical. Y. Kim: Employee; Self; Hanmi Pharmaceutical. S. Jung: None. S. Kim: Employee; Self; Hanmi Pharmaceutical. Stock/Shareholder; Self; Hanmi Pharmaceutical.
A Rapid Method for the determination of Dehydrated alcohol (Ethanol) content in Clobetasol propionate foam by Non-polar Capillary Gas chromatography (2021)

Clobeatsol propionate foam is a topical class 1 corticosteroid used to treat itching and inflammatory arthritis on the skin occurred by allergic reactions, psoriasis and eczema. In the pharmaceutical aerosol products, Dehydrated alcohol (Ethanol) is the primary ingredient and its concentration level in the formulation composition plays a significant role in the regulation of aerosol rate, droplet shape and particle size. It can also act as solubilizer for active pharmaceutical ingredient, topical disinfectant and skin permeation enhancer. Hence accurate assay of Ethanol is a crucial quality control component. A simple and rapid gas chromatography method was developed to quantify Ethanol content in Clobetasol propionate foam drug product using fused silica glass tube non-polar capillary column (HP-5, 30 m, 0.53 mm, 1.5 µm). Ethanol in the sample was diluted with methanol after adding suitable amount of internal standard, the isopropyl alcohol solution.The developed method is precise, linear and accurate in the range of 5 mg/mL to 15 mg/mL of nominal concentration of ethanol i.e. 10 mg/mL . The presented method has an advantage of a very quick gas chromatographic separation (less than 16 min) and therefore is highly suitable for in-process and stability analysis of Ethanol content in Clobetasol propionate foam drug product.
Development of Human Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonists. 1. Potent and Selective Small Molecule CGRP Antagonists. 1-[N2-[3,5-Dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1- piperidinyl]carbonyl]-d-tyrosyl]-l-lysyl]-4-(4-pyridinyl)piperazine:  The First CGRP Antagonist for Clinical Trials in Acute Migraine (2005)

Although the triptans have greatly improved the acute treatment of migraine headache, there are yet many shortcomings. Therefore, new strategies for the treatment of migraine are needed which offer advantages over current therapy, e.g. triptans. Our novel approach was based on the hypothesis that the release of calcitonin gene-related peptide (CGRP) could play a causative role in migraine headache. Thus we initiated a program aimed at the design and synthesis of small molecule CGRP receptor antagonists. High throughput screening led to the identification of (R)-Tyr-(S)-Lys dipeptide-like compounds that showed weak but unequivocal binding to the human CGRP receptor. Lead optimization afforded highly potent CGRP antagonists, the prototype being compound 19 (BIBN4096). This compound exhibiting a favorable biological profile was selected for initial clinical trials. A proof of concept study indicated that intravenous application of 19 was effective in the treatment of acute migraine headache. This finding strongly supports our initial working hypothesis that CGRP plays an important role in the pathophysiology of migraine.
Continuous-Flow Left Ventricular Assist Device Support in Patients with Advanced Heart Failure: Points of Interest for the Daily Management (2012)

Today, continuous-flow left ventricular assist devices (cf-LVADs) are implanted more often in patients with end-stage heart failure. Because of greater durability they can be implanted for an extended period of time. As a result of increased numbers of patients on cf-LVAD support, healthcare professionals should be aware of the potential complications inherent to this therapy. Both bleeding and thrombosis may occur, and also complications related either to the device itself or to the ensuing altered haemodynamics, valvular pathology, and rhythm disturbances such as ventricular tachycardias and fibrillation. Accurate clinical evaluation, together with an electrocardiogram and, if necessary, combined with an echocardiogram, is obligatory in these situations. This review summarizes common complications complemented by a few clinical cases.
Basal catecholamine and cortisol secretion in primary chromaffin cell cultures before and after purification and retroviral transfection (1998)

We have investigated the effects of supraphysiological concentrations of catecholamines on glucocorticoid secretion in vitro. These effects were analyzed in adrenocortical cells shown to be present in chromaffin cell cultures as well as in cortical cells cocultured with transfected chromaffin cells that overproduce catecholamines. Cortisol release from residual cortical cells in chromaffin cell cultures was found to be 2.5 times higher than from isolated adrenocortical cells. Removal of the adrenocortical cells from the chromaffin cells resulted in an almost complete cessation of cortisol secretion. Catecholamine overproduction was achieved by transfecting chromaffin cells with the blank retroviral vector pSAM-EN. Coculture of adrenocortical cells with these transfected chromaffin cells further enhanced the stimulating effect of chromaffin cells on cortisol 2.3-fold compared to normal cocultures. In conclusion, cortical cells in chromaffin cell cultures secrete significant amounts of cortisol, which should be considered when evaluating the endocrine function of these cell cultures and which can be abolished by purification. The hormonal activity of adrenocortical cells is highly increased in an environment of catecholamine overproduction, which is of both basic and clinical importance.