gebhart/patrepeval huggingface dataset:
Predictors of antiviral treatment initiation in hepatitis C virus‐infected patients: a Danish cohort study (2009)

Predictive factors for initiation of antiviral therapy in chronically infected hepatitis C virus (HCV) patients are not fully elucidated. The aim of this study was to determine predictive factors for initiation of treatment with standard or pegylated interferon either alone or combined with ribavirin. A Danish cohort of individuals chronically infected with HCV was used and observation time was calculated from the date of inclusion in the cohort to date of death, last clinical observation, 1 January 2007, or start of HCV antiviral treatment in treatment-naïve patients. Kaplan-Meier survival analysis was used to construct time to event curves. Cox regression was used to determine the incidence rate ratios as estimates of relative risk (RR) and 95% confidence intervals (CI). A total of 1780 patients were enrolled in the study. The cumulative chance of treatment initiation over 5 years was 33.0%. We found several strong predictors of treatment initiation: elevated alanine aminotransferase [>2 times upper limit (RR = 2.17, 95% CI 1.64-2.87), >3 times upper limit (RR = 3.64, 95% CI 2.75-4.81)], genotype 2 or 3 (RR = 1.86, 95% CI 1.49-2.31) and HIV co-infection (RR = 0.28, 95% CI 0.15-0.53). To our knowledge, this study is the first to estimate factors predicting initiation of antiviral treatment in patients with chronic HCV infection on a nationwide scale. We found that several of the factors predicting initiation of antiviral treatment correlate with factors known to predict a better response to treatment and factors known to increase the progression of liver disease.
Photocatalytic film of BiOCl honeycomb array from anodic aluminium oxide template (2015)

Different from traditional photocatalysts, this work studies a novel photocatalytic film. The film is based on an anodic aluminium oxide (AAO) film with BiOCl honeycomb array covering the surface. The photocatalytic property of BiOCl is improved without adding any dopant. AAO is used as template to control the growth of BiOCl. The novelty of this work is to use the surface of AAO instead of the holes as template to control the growth of nanomaterials. A well ordered multilayer honeycomb array is formed on the surface of AAO, which is composed of dendritic BiOCl flakes. The BiOCl honeycomb exhibits higher photocatalytic activity in the degradation of rhodamine B under UV–Vis irradiation compared with BiOCl flakes grown without template. The unique advantage of the BiOCl honeycomb covered AAO is to be used as a film in waste water treatment and is easy to regenerate.
Nance–Horan syndrome protein, NHS, associates with epithelial cell junctions (2006)

Nance-Horan syndrome, characterized by congenital cataracts, craniofacial, dental abnormalities and mental disturbances, is an X-linked disorder with significant phenotypic heterogeneity. Affected individuals have mutations in the NHS (Nance-Horan syndrome) gene typically resulting in premature truncation of the protein. This report underlines the complexity of the regulation of the NHS gene that transcribes several isoforms. We demonstrate the differential expression of the two NHS isoforms, NHS-A and NHS-1A, and differences in the subcellular localization of the proteins encoded by these isoforms. This may in part explain the pleiotropic features of the syndrome. We show that the endogenous and exogenous NHS-A isoform localizes to the cell membrane of mammalian cells in a cell-type-dependent manner and that it co-localizes with the tight junction (TJ) protein ZO-1 in the apical aspect of cell membrane in epithelial cells. We also show that the NHS-1A isoform is a cytoplasmic protein. In the developing mammalian lens, we found continuous expression of NHS that became restricted to the lens epithelium in pre- and postnatal lens. Consistent with the in vitro findings, the NHS-A isoform associates with the apical cell membrane in the lens epithelium. This study suggests that disturbances in intercellular contacts underlie cataractogenesis in the Nance-Horan syndrome. NHS is the first gene localized at TJs that has been implicated in congenital cataracts.
Use of Gelation Theory To Characterize Metal Cross-Linked Polymer Gels (1986)

This chapter presents a novel approach to characterize metal cross-linked polymer gels through the use of gelation theory and rheological concepts and measurements. A simple gelation model that provides the essential features of a liquid-gel phase diagram is used. This model introduces the importance of a critical polymer concentration (C*) for gelation and the gel-liquid transition temperature (Tc). These two properties of a polymer solution or gel determine, to a great extent, the rheological properties of fracturing gels. In this work, C* and the Tc are determined experimentally by using rheological techniques. Their impact on the rheological properties of fracturing gels is discussed.
The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility (2014)

The epidermal growth factor receptor (EGFR) is a member of the ErbB family that can promote the migration and proliferation of breast cancer cells. Therapies that target EGFR can promote the dimerization of EGFR with other ErbB receptors, which is associated with the development of drug resistance. Understanding how interactions among ErbB receptors alter EGFR biology could provide avenues for improving cancer therapy. We found that EGFR interacted directly with the CYT1 and CYT2 variants of ErbB4 and the membrane-anchored intracellular domain (mICD). The CYT2 variant, but not the CYT1 variant, protected EGFR from ligand-induced degradation by competing with EGFR for binding to a complex containing the E3 ubiquitin ligase c-Cbl and the adaptor Grb2. Cultured breast cancer cells overexpressing both EGFR and ErbB4 CYT2 mICD exhibited increased migration. With molecular modeling, we identified residues involved in stabilizing the EGFR dimer. Mutation of these residues in the dimer interface destabilized the complex in cells and abrogated growth factor-stimulated cell migration. An exon array analysis of 155 breast tumors revealed that the relative mRNA abundance of the ErbB4 CYT2 variant was increased in ER+ HER2- breast cancer patients, suggesting that our findings could be clinically relevant. We propose a mechanism whereby competition for binding to c-Cbl in an ErbB signaling heterodimer promotes migration in response to a growth factor gradient.
Enantioselective Hydrosilylation with Chiral Frustrated Lewis Pairs (2012)

Frustrated partners: Based on an initial mechanistic investigation, enantioselective hydrosilylation of various imines was accomplished for the first time by using a novel chiral frustrated Lewis pair (FLP) catalyst. High enantioselectivities of up to 87 % were obtained demonstrating the effectiveness of these metal-free chiral catalysts for this transformation (see scheme). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Cytochrome c Release from CNS Mitochondria and Potential for Clinical Intervention in Apoptosis-Mediated CNS Diseases (2005)

Apoptosis is critical for normal development and tissue homeostasis. However, its abnormal occurrence has been implicated in a number of disorders, including neurodegenerative diseases and stroke. Translocation of cytochrome c (Cyt c) from mitochondria to the cytoplasm is a key step in the initiation and/or amplification of apoptosis. Here we discuss Cyt c release in apoptosis with its impact on the CNS and review our studies of Cyt c release from isolated rat brain mitochondria in response to several insults. Calcium-induced Cyt c release, as occurs in neurons during stroke and ischemia, involves rupture of the mitochondrial outer membrane (MOM) and can be blocked by inhibitors of the mitochondrial permeability transition (mPT). Thus, inhibitors of the mPT have shown efficacy in animal models of ischemia. In contrast, proapoptotic proteins, such as BID, BAX, and BAK, induce Cyt c release independently of the mPT without lysing the MOM. Several inhibitors of BAX-induced Cyt c release have shown promise in models of CNS apoptosis. Because of their distinct mechanisms for Cyt c release, both the mPT and proapoptotic proteins should be targeted for effective clinical intervention in CNS disorders involving apoptosis.
Development of a New Method for Pulse Push/Pull Hemodialysis (2011)

Although hemodiafiltration is presumed to be a gold standard for higher convective therapy for kidney failure patients, the repetition of forward and backward filtration during hemodialysis increases the total filtration volume and convective clearance. Hence, the authors describe a new method of enhancing forward filtration and backfiltration. The devised method, named pulse push/pull hemodialysis (PPPHD), is based on the utilization of dual pulsation in a dialysate stream; namely, pulsatile devices in the dialysate stream both upstream (a dialysate pump) and downstream (an effluent pump) of the dialyzer. Fluid management accuracy of the unit was assessed using fresh bovine blood, and its hemodialytic performance was investigated in a canine renal failure model. Forward filtration rates during PPPHD were maintained at the levels of dialysate flow rates. Fluid balancing error was less than ±0.84% of total dialysate volume, when 97.4 ± 1.66L of pure dialysate was circulated for 4 hs. The animal remained stable without any complication. Urea and creatinine reductions were 56.9 ± 1.6 and 52.8 ± 2.3%, respectively, and albumin levels remained uniform throughout treatment. The devised PPPHD unit offers a simple, but efficient strategy of combined simultaneous diffusive and convective solute transport for ESRD patients, without the need for external replacement infusion.
A recommender system based on local topology features and message rate (2015)

Social networks have become an indispensable part of every day's life. A vast majority of people use at least one social network to communicate with friends or business partners. Different applications of social networks are used to meet diverse needs of users. Social networks use recommender systems to provide wider experience for their users. Friend recommendation has been the most popular and important application used to expand the circle of friends and social communication. Social networks are very dynamic. Every moment new people are added and new forms of relationship are formed. Therefore, evaluating social networks is a complicated task. In this paper, the focus is both on the characteristics of social networks as well as the messages sent between and among the nodes. A mixed method will be suggested which will initially use a community detection algorithm based on message rate as a pruning algorithm. It will then divide the network into several communities. Afterwards, the FriendLink algorithm will be employed in order to estimate the similarity score between all users based on the properties of the network structure and the rate of the messages sent. Finally, users with maximal similarity will be suggested as friends to the target user. The results of testing a Facebook-like dataset revealed that the suggested method is of a great precision and accuracy as compared to FriendLink and CSM algorithms.
Time Optimum Control for Reactors with Two Kinds of Internal Feedback (1966)

A control to bring the state of a reactor system to equilibrium state in time optimum manner is discussed.Non-linear integral equations containing the effects of two kinds of internal feedback and delayed neutrons and also the effect of external control are adopted for the dynamic equations of the system.These equations are reduced to quasilinear (parametric) differential equations, on which the external control applies in the form of a combination of the c:>ntrol reactivity, its rate of change and its acceleration.Pontryagin's Maximum Principle is applied to a quasilinear system, and several modes of optimum control patterns -nodal, focal, saddle and mixed -are obtained according to the nuclear and thermal properties, the thermal output of the reactor and magnitude of the control.Optimum control is obtained in the form of piecewise constant control referred to a new control parameter which consists of a linear combination of the control reactivity, its rate of change and its acceleration.
Antibacterial Efficacy of Two Commercially Available Bacteriophage Formulations, Staphylococcal Bacteriophage and PYO Bacteriophage, Against Methicillin-Resistant Staphylococcus aureus: Prevention and Eradication of Biofilm Formation and Control of a Systemic Infection of Galleria mellonella Larvae (2020)

Sessile bacteria growing on surfaces are more resistant to standard antibiotics than their planktonic counterpart. Due to their antimicrobial properties, bacteriophages have re-emerged as a promising approach to treat bacterial biofilm-associated infections. Here, we evaluated the ability of two commercially available phage formulations, Staphylococcal bacteriophage (containing the monophage Sb-1) and PYO bacteriophage (a polyphage), in preventing and eradicating an <i>in vitro</i> biofilm of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) by isothermal microcalorimetry and high-resolution confocal laser scanning microscopy (CLSM). Moreover, to assess the potential <i>in vivo</i> efficacy of both phage preparations, a <i>Galleria mellonella</i> model of MRSA systemic infection was used. Microcalorimetry measurement showed that 10<sup>7</sup> PFU/ml (the highest tested titer) of both phage formulations were able to inhibit planktonic growth in a concentration-dependent manner. However, MRSA biofilm was eradicated only by co-incubation of 5-7 days with the highest phage titers, respectively. In the experiments of biofilm prevention, isothermal microcalorimetry revealed that the heat production was completely abolished in the presence of sub-inhibitory titers (10<sup>4</sup> PFU/ml) of phages. These data were also confirmed by confocal laser scanning microscopy. Both phage formulations increased the survival of <i>G. mellonella</i> larvae preventing or treating MRSA infection compared to untreated control. In conclusion, tested phage formulations are promising for preventing device colonization and killing biofilm bacteria attached on a surface. Novel strategies for direct coating and release of phages from material should be investigated.
Supervivencia y crecimiento de Celtis tala Gillies ex Planch en la rehabilitación ecológica de canteras de conchilla abandonadas (2021)

In the east of the province of Buenos Aires, the mining of calcareous subsoil materials causes the loss of cover of native forests dominated by Celtis tala, one of the main forest formations in the region. The objective of this study was to evaluate the tala plantation techniques in areas of abandoned quarries, to improve the ecological rehabilitation of such areas. Our hypothesis is that survival and growth are negatively affected by the low availability of fertile soil, the competition with herbaceous plants and high the direct solar radiation incidence. We carried out a field study to estimate survival, diameter at the stem base and height of tala plants as a response to weeding and shelter in a gradient of fertile soil availability. Survival increased with soil depth, and we observed a positive response of growth rate to weeding, which was greater at high fertile soil availability. Only a weak positive effect of shelter on growth was observed at higher fertile soil availability. The loss of forest cover caused by mining cannot be reversed with simple planting techniques. It is necessary to understand the ecophysiological processes that limit the establishment of tala and to plan the management of the remaining fertile soil. Other local tree species should also be assayed.
Aeroacoustic sources identification using generalized inverse beamforming (2010)

Aeroacoustic source identification poses some challenges to the conventional techniques such as the conventional beamforming. The challenges can be summarized as the distributed nature of the aeroacoustic sources, in coherent or incoherent radiation, with multipole radiation characteristics. In order to cope with these difficulties, the Generalized Inverse Beamforming (GIB) is adopted. This method allows the simultaneous identification of compact or distributed, coherent or incoherent, mono or multipole sources, with a reduced number of sensor signals. The method is applied to an aeroacoustic test using a simple geometry as obstacle in a low Mach number jet. The result focuses on the dipole formation on the circular cylinder surface. Convection and refraction influence are included in the identification using a simplified approach for the retarded time calculation. Equivalent pressure mappings are generated to help visualization of the radiation field. This work investigates the performance obtained on the use of the GIB method on this simple aeroacoustic source identification problem.
Management of the Parathyroid Glands During Preventive Thyroidectomy in Patients With Multiple Endocrine Neoplasia Type 2 (2015)

In patients with MEN2A treated by preventive total thyroidectomy routine total parathyroidectomy with autotransplantation and CND gives excellent long-term results. However, preservation of the parathyroids in situ during preventive thyroidectomy combined with selective CND based on preoperative basal serum calcitonin levels is an effective and safe alternative that results in a very low incidence of hypoparathyroidism.
Smart-media applications created by scenario based modeling (2004)

Okude Laboratory at Keio University SFC implements some original applications by a unique method. These applications are focused on a prime user needs and representing the future user life style using the scenario-based modeling method. We defined these interactive media embedded in the user environment as smart-media applications. Now our projects are going on five domains of the smartmedia applications; smart graphics, smart object, smart fashion, smart environment and smart collaboration. This paper shows productions as achievements of the scenario-based modeling on these projects.
Editorial: Systems biology and personalized medicine – the future is now (2012)

This special issue on "Systems biology and personalized medicine" includes five complementary articles that highlight how functional genomics and computational physiology can contribute to the development of predictive, preventive, personalized and participatory (P4) medicine. Edited by Prof. Leroy Hood and Prof. Charles Auffray.
Snowmobile Suspension System Design Under University-Industry Collaboration (1989)

&lt;div class="htmlview paragraph"&gt;The modelling and analysis of a snowmobile are carried out to study its ride dynamics. The work is carried out in two phases. In phase 1, the various components such as shock-absorbers and suspension linkages are modelled and studied separately,. using both analytical and experimental methods. In the second phase, the mathematical model of the complete snowmobile is created which includes the component models created in phase 1. A computer simulation software was then developed to predict the dynamic behaviour of the vehicle.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The kinematic analysis and design of the suspension linkages are carried out using a newly developed general purpose program for planar linkages, called GENKAD. The force-generation characteristics of the suspensions derived from this program are used in a 2-degrees-of-freedom (bounce and pitch) vehicle model to evaluate driver ride comfort. The enveloping action of the ski and track are taken into account by using a terrain pre-processor. ‘Discrete event simulation’ is carried out for the vehicle traversing bumps at various speeds. This modular approach to analysis and design allows for efficient product development.&lt;/div&gt;
Discovery of an M8.5 Dwarf with Proper Motion μ = 2[farcs]38 per Year (2002)

We report the discovery of LSR1826+3014, a very faint (V=19.36) star with a very large proper motion (mu=2.38 arcsec/yr). A low resolution red spectrum reveals that LSR1826+3014 is an ultra-cool red dwarf with spectral type M8.5 V and with a radial velocity v_rad=+77+/-10 km/s. LSR1826+3014 is thus the faintest red dwarf ever discovered with a proper motion larger than 2 arcsec/yr. Optical and infrared photometry suggest that the star is at a distance d=13.9+/-3.5 pc from the Sun, which implies it is moving relative to the local standard of rest with a total velocity of 175+/-25 km/s. Numerical integration of its orbit suggests that LSR1826+3014 is on a halo-like galactic orbit.
Seamless Video Stitching from Hand‐held Camera Inputs (2016)

Abstract Images/videos captured by portable devices (e.g., cellphones, DV cameras) often have limited fields of view. Image stitching, also referred to as mosaics or panorama, can produce a wide angle image by compositing several photographs together. Although various methods have been developed for image stitching in recent years, few works address the video stitching problem. In this paper, we present the first system to stitch videos captured by hand‐held cameras. We first recover the 3D camera paths and a sparse set of 3D scene points using CoSLAM system, and densely reconstruct the 3D scene in the overlapping regions. Then, we generate a smooth virtual camera path, which stays in the middle of the original paths. Finally, the stitched video is synthesized along the virtual path as if it was taken from this new trajectory. The warping required for the stitching is obtained by optimizing over both temporal stability and alignment quality, while leveraging on 3D information at our disposal. The experiments show that our method can produce high quality stitching results for various challenging scenarios.
Roseomonas mucosa Isolated from Bloodstream of Pediatric Patient (2010)

We report a case of catheter-related bacteremia associated with Roseomonas mucosa isolated from an immunocompromised pediatric patient with a history of multiple episodes of urinary tract infection and bacteremia.
Model to predict the response of correlation spectroscopy gas detection systems for CH (2003)

Mueller matrix (MM) polarimetry can provide comprehensive information about the polarization properties that are closely related to the microstructural features and has demonstrated its potential in biomedical studies and clinical practices, and bright-field microscopy is widely used in pathological diagnosis as the golden standard. In this work, we improve the throughput of MM microscopy by learning a statistical transformation between these two imaging systems based on deep learning. Using this approach, the MM microscope can generate an image that is equivalent to a bright-field microscope image of the matching field of view. We add new transformative capability to the existing MM imaging system without requiring extra hardware. The translation model is based on conditional generative adversarial network with customized loss functions. We demonstrated the effectiveness of our approach on liver and breast tissues and evaluated the performance by four quantitative similarity assessment methods in pixel, image and distribution levels, respectively.
The Calcium Isotope Composition (δ44/40Ca) of NIST SRM 915b and NIST SRM 1486 (2008)

The calcium isotopic composition of NIST SRM 915b and 1486 provided by the National Institute of Standards and Technology was analysed. The δ 44/40 Ca values of the two reference materials relative to NIST SRM 915a were: NIST SRM 915b =+0.72 ± 0.04‰ and NIST SRM 1486 =−1.01 ± 0.02‰. NIST SRM 1486 did not require any chemical separation prior to measurement.