gebhart/patrepeval huggingface dataset:
Eco-visualization (2007)

Can creative visualizations of real time energy consumption patterns trigger more ecologically responsible behavior? Media art that displays the real time usage of key resources such as electricity offers new strategies to conserve energy in the home and workplace. This paper details the development of a public art project created for the National Center for Supercomputing Applications that measures electricity usage in real time for the purpose of education and curtailment of power usage. A version of this piece will be on view in the exhibition, Speculative Data and the Creative Imaginary, a component of the 2007 Creativity and Cognition conference.
Traditional insect bioprospecting – As human food and medicine (2009)

The wisdom that indigenous people have regarding bioprospecting is embedded in their belief system and their culture. Food insects play an important role in the new insect focus. Ants, bees, termites, caterpillars, water bugs, beetle larvae, flies, crickets, katydids, cicadas, and dragonfly nymphs are among a long list of edible insects that provide nutrition for the people of Asia, Australia, Africa, South America, the Middle East, and the Far East. Insects represent an important food source for a wide variety of other animal species. By weight, termites, grasshoppers, caterpillars, weevils, houseflies and spiders are better sources of protein than beef, chicken, pork or lamb. The traditional healers use Insects as medicine. Chemicals produced by insects against self defense can be used for antibacterial and anticancer drugs. The nutritional and economic value of edible insects is often neglected and we should further encourage their collection and commercialization, given the benefits to the environment and human health. It is an interesting concept, managing pest insects by developing them into a sought after delicacy.
Assessment of critical events corridors through multivariate cascading outages analysis (2011)

Massive blackouts of electrical power systems over the past decade has focused increasing attention to cascading events that may lead to widespread network collapses. It is important to be able to identify places in the system where the cascading events are most likely or/and lead to the most severe consequences. Based on this information, transmission planning decisions can be made that minimize the risk of blackouts in the most efficient way. This paper addresses all these issues. First, it outlines a method to simulate cascading failures resulting from multiple extreme initiating events. The method is currently confined to analyzing steady state power-system responses to extreme events and uses a simplified model of protection system. The second goal is to determine parts of the network vulnerable cascading failures. The hypothesis of critical events corridors is proposed to represent repeating sequential outages that can occur in the system for multiple initiating events. The new concept helps to identify system reinforcements that planners could engineer in order to “break” the critical events sequences and therefore lessen the likelihood and consequences of cascading outages. This hypothesis has been successfully validated with a California power system model.
Expression and Characterization of Bluetongue Virus Serotype 21 VP7 Antigen: C-Terminal Truncated Protein has Significantly Reduced Antigenicity (2010)

In the present study, group-specific antigen VP7 of bluetongue virus (BTV) serotype 21 isolated from cattle in Tochigi prefecture in Japan in 1994 was characterized by sequencing and expression. Gene was amplified from cDNA synthesized on viral dsRNA using reverse-transcriptase-PCR. Nucleotide sequence of this isolate showed high similarity with other published BTV VP7 sequences. Full-length and C-terminal truncated forms of VP7 were expressed in insect cells by a baculovirus gene expression system under control of the viral polyhedrin promoter. Expression of full-length recombinant VP7 was confirmed by immunoprecipitation with VP7 specific monoclonal antibody (8A3B.6, ATCC). Recombinant proteins expressed with or without 6x His-tag showed good expression levels in TN5 cells and reacted well with the monoclonal antibody in the indirect ELISA. However C-terminal truncated VP7 with His-tag failed to react with this monoclonal antibody, while poor antigenicity was evident when it was reacted with infected bovine serum. Reduced antigenicity of the latter suggested that C-terminal truncation affects 8A3B.6 epitope construction probably via inhibition of VP7 trimer structure formation.
Comparison of annotating duplication, tree mapping, and copying as methods to compare gene trees with species trees (1997)

This paper reviews the authors work on the idea of employing the mechanism of gene duplication in explaining the di erences between a gene and species trees Three existing approaches are presented as based on a tree mapping b annotating duplication and c copying duplication modeling Correspondences between a and b and b and c are mathematically explored It is proven in particular that approaches b and c lead to equivalent duplication histories Moreover all the three approaches equivalently count the numbers of duplications and losses needed to explain all the di erences between trees
Efficacy of Formulated Baits for Control of Argentine Ant (Hymenoptera: Formicidae) (1991)

We developed a laboratory method to determine the potential efficacy of baits formulated for control of the Argentine ant, Iridomyrmex humilis (Mayr). Possible effects as insect growth regulators were not examined. Of the 10 formulated baits tested, only mirex applied to granulated silkworm pupae had delayed toxicity. Hydramethylnon applied to granulated silkworm pupae also provided excellent kill of workers but did not exhibit delayed toxicity. In field tests, this bait provided faster control than did a chemical barrier of granular diazinon.
<title>Measurement of windage heating effects on high-speed rotating disks using ESPI</title> (1995)

Real-time analysis of component deformation under service conditions would form the optimum experimental optical technique. Approaching this ideal is pulsed laser electronic speckle pattern interferometry (ESPI) which can provide in-plane displacement information from high speed rotating components over a wide range of rotational speeds with tangential velocities currently up to 300 m s<SUP>-1</SUP>. With the rapid advancement of computers, the Fourier transform method of analysis of interference fringe patterns for full field information has been reduced to just a few minutes. The testing of high speed discs in air, with particular reference to gas turbine disc behavior has provided the ability to display the effects of windage heating of the discs, in addition to changes of speed. The technique is sufficiently accurate to record both short term differential heating across the disc, as well as the longer term overall growth.
Alcanivorax xiamenensis sp. nov., a novel marine hydrocarbonoclastic bacterium isolated from surface seawater (2023)

A novel <i>Alcanivorax</i>-related strain, designated 6-D-6<sup>T</sup>, was isolated from the surface seawater collected around Xiamen Island. The novel strain is Gram-stain-negative, rod-shaped and motile, and grows at 10-45 °C, pH 6.0-9.0 and in the presence of 0.5-15.0 % (w/v) NaCl. Phylogenetic analysis based on the 16S rRNA gene sequences indicated that it belongs to the genus <i>Alcanivorax</i>, with the highest sequence similarity to <i>Alcanivorax dieselolei</i> B5<sup>T</sup> (99.9 %), followed by <i>Alcanivorax xenomutans</i> JC109<sup>T</sup> (99.5 %), <i>Alcanivorax balearicus</i> MACL04<sup>T</sup> (99.3 %) and other 13 species of the genus <i>Alcanivorax</i> (93.8 %-95.6 %). The digital DNA-DNA hybridization and average nucleotide identity values between strain 6-D-6<sup>T</sup> and three close type strains were 40.1-42.9/90.6-91.4 %, and others were below 22.9/85.1 %, respectively. The novel strain contained major cellular fatty acids of C<sub>16 : 0</sub> (31.0 %), C<sub>19 : 0</sub> <i> </i>ω8<i>c</i> cyclo (23.5 %), C<sub>17 : 0</sub> cyclo (9.7 %), C<sub>12 : 0</sub> 3OH (8.6 %), summed feature 8 (7.6 %) and C<sub>12 : 0</sub> (5.4 %). The genomic G+C content of strain 6-D-6<sup>T</sup> was 61.38 %. Phosphatidylethanolamine, phosphatidylglycerol, diphosphatidylglycerol, two unidentified phospholipids and one amino-group-containing phospholipid were detected. On the basis of phenotypic and genotypic characteristics, strain 6-D-6<sup>T</sup> represents a novel species within the genus <i>Alcanivorax</i>, for which the name <i>Alcanivorax xiamenensis</i> sp. nov. is proposed. The type strain is 6-D-6<sup>T</sup> (=MCCC 1A01359<sup>T</sup>=KCTC 92480<sup>T</sup>).
The Interplay of Electrostatics and Chemical Positioning in the Evolution of Antibiotic Resistance in TEM β-Lactamases (2021)

The interplay of enzyme active site electrostatics and chemical positioning is important for understanding the origin(s) of enzyme catalysis and the design of novel catalysts. We reconstruct the evolutionary trajectory of TEM-1 β-lactamase to TEM-52 toward extended-spectrum activity to better understand the emergence of antibiotic resistance and to provide insights into the structure-function paradigm and noncovalent interactions involved in catalysis. Utilizing a detailed kinetic analysis and the vibrational Stark effect, we quantify the changes in rates and electric fields in the Michaelis and acyl-enzyme complexes for penicillin G and cefotaxime to ascertain the evolutionary role of electric fields to modulate function. These data are combined with MD simulations to interpret and quantify the substrate-dependent structural changes during evolution. We observe that this evolutionary trajectory utilizes a large preorganized electric field and substrate-dependent chemical positioning to facilitate catalysis. This governs the evolvability, substrate promiscuity, and protein fitness landscape in TEM β-lactamase antibiotic resistance.
Development of a Lunar Lander Simulator: Commemorating Apollo and Looking to the Future (2020)

July 20, 2019 at 3:17 PM Eastern Standard Time (EST) marked the 50th anniversary of the successful landing of the Apollo 11 lunar module on the moon’s surface. This landing achieved a significant milestone in President Kennedy’s challenge to the United States – a milestone enabled by engineers and the significant engineering and technology advancements of the time. Draper, formerly the MIT Instrumentation Laboratory, was the first prime contract issued as part of NASA’s Apollo Program – providing the Guidance and Navigation system for the spacecraft. As part of Draper’s commemoration of the Engineers and Engineering that made it possible to go to the moon and return safely to Earth, we designed and developed a 6-degree-of-freedom (6-DOF) motion-based lunar lander simulator to replicate the Apollo Lunar Module (LM) cockpit interior, flight controls, displays, vehicle dynamics, audio, and out-the-window visualizations from “low gate” (approximately 500 feet altitude and 1,500 feet up-range) to the Apollo 11 landing site – roughly 100 seconds of flight. The cockpit displays, which were a combination of digital and analog gauges in the LM, were digitized and presented on several flat panel screens – including the Display and Keyboard (DSKY). This enables not only a re-creation of the instrumentation that the Apollo astronauts had available to them to pilot the LM, but also provides flexibility for designing, prototyping, and evaluating next-generation flight displays and control modes for future piloted lunar landing vehicles. This paper summarizes Draper’s design and development of this motion-based lunar lander simulator to commemorate the Engineers and Engineering that made landing on the moon 50 years ago possible, and projects the opportunities that this capability enables for a human return to the moon.
SUCCESS: a next-generation hybrid WDM/TDM optical access network architecture (2004)

In this paper, the authors propose a next-generation hybrid WDM/TDM optical access network architecture called Stanford University aCCESS or SUCCESS. This architecture provides practical migration steps from current-generation time-division multiplexing (TDM)-passive optical network (PONs) to future WDM optical access networks. The architecture is backward compatible for users on existing TDM-PONs, while simultaneously capable of providing upgraded high-bandwidth services to new users on DWDM-PONs through advanced WDM techniques. The SUCCESS architecture is based on a collector ring and several distribution stars connecting the CO and the users. A semipassive configuration of the Remote Nodes (RNs) enables protection and restoration, making the network resilient to power failures. A novel design of the OLT and DWDM-PON ONUs minimizes the system cost considerably: 1) tunable lasers and receivers at the OLT are shared by all ONUs on the network to reduce the transceiver count and 2) the fast tunable lasers not only generate downstream data traffic but also provide DWDM-PON ONUs with optical CW bursts for their upstream data transmission. Results from an experimental system testbed support the feasibility of the proposed SUCCESS architecture. Also, simulation results of the first SUCCESS DWDM-PON MAC protocol verify that it can efficiently provide bidirectional transmission between the OLT and ONUs over multiple wavelengths with a small number of tunable transmitters and receivers.
Supplementary Table 6 from Molecular Profiling of Premalignant Lesions in Lung Squamous Cell Carcinomas Identifies Mechanisms Involved in Stepwise Carcinogenesis (2023)

&lt;p&gt;XLS file - 35KB, TP53 activity prediction and its target genes.&lt;/p&gt;
Cellular RNA Homologous to the Abelson Murine Leukemia Virus Transforming Gene: Expression and Relationship to the Viral Sequence (1983)

To examine the expression of the cellular homolog of the Abelson murine leukemia virus transforming gene (the v-abl sequence), a DNA probe representing the v-abl sequence was prepared. The probe detected two cytoplasmic polyadenylic acid-containing c-abl RNAs of about 6.5 and 5.5 kilobases in a variety of rodent cells, and slightly larger RNAs were detected in human cells. These two RNA species were found in all normal tissues or cell lines examined, but at differing concentrations: liver cells had the least, fibroblastic cell lines had the most. By using a probe able to detect the cellular but not the viral gene, the two RNAs were shown to be present in Abelson murine leukemia virus-transformed cells at levels found either in their untransformed counterparts or in similar cell types transformed by other means. The target cells of the virus have a somewhat elevated level of the two RNAs although expression of the c-abl gene is not restricted to these cells. The v-abl sequence lacks 0.35 and 0.85 kilobases of the c-abl RNA on the 5' and 3' ends, respectively. Thus, the Abelson murine leukemia virus transforming gene is an internal fragment of the transcript of a normal cellular gene.
Cytopathic effect of human immunodeficiency virus in T4 cells is linked to the last stage of virus infection. (1988)

A principal feature of acquired immunodeficiency syndrome is depletion of T4 lymphocytes, which is partly due to a direct cytopathic effect of the virus. Both syncytial formation (viral-induced cell fusion) and premature cell death have been cited as the major cause for this phenomenon. By kinetic analysis of cell proliferation and cell lysis we show that the cytopathic effect correlates chiefly with virus production from infected cells, including giant syncytial cells. Most T4 cells were, at least transiently, infected by human immunodeficiency virus (human T-lymphotropic virus type IIIB strain); however, after phytohemagglutinin activation, only 10-30% of infected cells express virus (and die) at any one time, indicating that virus production, followed by cell killing, is linked to immune activation and cell differentiation. We also show that an interval exists before viral release, in which expression of viral antigens occurs on the cell surface, suggesting that infected cells are immunogenic before viral production. If so, they may induce a cell-mediated immune response that could minimize dissemination of human immunodeficiency virus, a possibility that has influenced our approaches to the development of a vaccine for prevention of acquired immunodeficiency syndrome.
Le temps presse (2019)

L’exposition Le temps presse&amp;lt; présentée au Centre canadien d’architecture lors du 150e anniversaire du Canada propose une « contre-histoire environnementale du Canada ». J’expose ce récit et la façon dont il contribue à une critique nécessaire de la modernité. L’exposition participe davantage de l’autocritique d’un discours dominant centré sur lui-même qu’à une critique fondamentale du caractère colonialiste, patriarcal et anthropocentriste de la société contemporaine.
Entwicklung eines roboterbasierten Prüfstands für die Ermittlung der Langzeitbetriebsfestigkeit von beweglichen Karosserieteilen (2012)

Die Marktbedingungen in der Automobilindustrie sind durch kürzere Entwicklungszeiträume, eine zunehmende Anzahl an Komfortfunktionen und Fahrzeugderivaten sowie steigende Erwartungen an Qualität, Effizienz und Sicherheit geprägt. Die reale Erprobung ist ein kritischer Pfad im Entwicklungsprozess. Die vorliegende Arbeit beschreibt ein neues Prüfsystemkonzept für die Komponentenerprobung, welches diesen Anforderungen Rechnung trägt. Das Herzstück ist eine softwarebasierte Systemarchitektur zur Automatisierung von Prototypentests. Schwerpunkte sind die Flexibilität in der Praxisanwendung, die Ausweitung der Messdatenerfassung mit zweckmäßiger Verwaltung zur Bauteilüberwachung und Fehlerrekonstruktion sowie eine aufgabenorientierte Schnittstelle zur Integration von Robotern. Diese übernehmen die mechanische Betätigung von beweglichen Fahrzeugkomponenten. Anhand von zwei konkreten Beispielen, einem Prüfstand zur Absicherung von Fahrzeugtüren sowie einem Prüfstand für Steifigkeitsmessungen wird die Praxistauglichkeit nachgewiesen.
Tracking oxygen effects on MR signal in blood and skeletal muscle during hyperoxia exposure (1999)

Blood and muscle T1 and T2 relaxivity was examined under normoxic (air; 20.8% O2) and hyperoxic (100% O2) conditions to determine whether the oxygenation state of blood in the large vessels and in the microcirculation can be monitored in vivo. The femoral artery/vein and the soleus and gastrocnemius muscles were examined in healthy human male volunteers. Arterial blood T1 decreased with hyperoxia, while venous blood T2 increased, due to increased dissolved O2 and decreased deoxyhemoglobin, respectively. A biexponential T2 model of muscle is proposed, where the short T2 component reflects primarily the intracellular and interstitial compartments (in fast exchange), and the long T2 reflects blood. In this model, the long T2 component increased with hyperoxia exposure. This was more evident in slow twitch (soleus) than in fast twitch (gastrocnemius) muscle. It is concluded that changes in the long T2 component reflect change in the microcirculation oxygenation state.
Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock (2005)

Activation of the mitogen-activated protein kinase (MAPK) cascade after Toll-like receptor stimulation enables innate immune cells to rapidly activate cytokine gene expression. A balanced response to signals of infectious danger requires that cellular activation is transient. Here, we identify the MAPK phosphatase dual specificity phosphatase 1 (DUSP1) as an essential endogenous regulator of the inflammatory response to lipopolysaccharide (LPS). DUSP1-deficient (DUSP1-/-) bone marrow-derived macrophages showed selectively prolonged activation of p38 MAPK and increased cytokine production. Intraperitoneal challenge of DUSP1-/- mice with LPS caused increased lethality and overshooting production of interleukin (IL)-6 and tumor necrosis factor alpha. Transcriptional profiling revealed that DUSP1 controls a significant fraction of LPS-induced genes, which includes IL-6 and IL-10 as well as the chemokines CCL3, CCL4, and CXCL2. In contrast, the expression of the important mediators of endotoxin lethality, interferon gamma and IL-12, was not significantly altered by the absence of DUSP1. These data together demonstrate a specific regulatory role of DUSP1 in controlling a subset of LPS-induced genes that determines the outcome of endotoxin shock.
Is agriculture the future of urban and periurban spaces?Te case of the city region of Tours (2017)

International audience
Japanese Communist Party (2009)

In October of 1898 a small group of Japanese intellectuals held the first meeting of the Shakaishugi Kenkyukai (Association for the Study of Socialism) in Tokyo. A variety of western socialist ideas was presented, among them the philosophies of Charles Fourier, Louis Blanc, Ferdinand Lassalle, and Karl Marx. The dominant force in the socialist leanings was marked by pacifism and a Christian humanism entrenched in the early years of the Japanese socialist faction holds historical sway over the current philosophical and political efforts of the Japanese Communist Party (JCP) in contemporary Japan.
Chemotherapy plus concomitant low-dose fractionated radiotherapy as second-line treatment for recurrent or progressive glioblastoma after temozolomide-based chemoradiation: A pilot study. (2011)

2083 Background: Second-line treatment in recurrent or progressive glioblastoma (GBM) has not yet been defined. Since in vitro and preclinical studies demonstrated a hyper-radiosensitivity of human malignant glioma cell lines to low doses fractionated radiotherapy (LD-FRT) and a synergism with chemotherapy, we performed a pilot study to evaluate the feasibility and efficacy of this approach. Methods: Eligibility criteria were: radiological diagnosis of recurrent or progressive GBM, previously treated by surgical resection followed by 3D-CRT (total dose 59,4 Gy) plus concomitant and adjuvant TMZ. Patients with recurrent or progressive disease during adjuvant TMZ received 30 cGy twice a day on days 1-2,8-9,15-16, q42, concurrently with fotemustine (40 mg/m2 on days 1, 8, 15) and cisplatin (30 mg/m2 on days 2, 9, 16), whereas in patients with recurrent/progressive disease occurring more than 6 months after the end of adjuvant TMZ a re-challenge with TMZ (150/200 mg/m2) concurrently with LD-FRT (40 cGy twice a day, over consecutive 5 days, q28) was attempted. Primary endpoints were toxicity (RTOG criteria) and efficacy (RECIST criteria); Progression Free Survival (PFS) and Overall Survival (OS) were also evaluated. Results: From February 2008 to January 2011, 20 patients were enrolled. The median total dose of LD-FRT was 760 cGy (range, 240-1200). The associated chemotherapy was based on cisplatin and fotemustine in 7 patients and on TMZ in 13 patients. Hematologic toxicity was mild, with a G3-4 (leucopenia) observed in 5% of patients; no treatment related death was observed. One out of 20 patients (5%) had a complete response, 1 patient (5%) experienced a partial response (PR), while 5 patients (25%) had a stable disease (SD) lasting at least 8 weeks (Clinical Benefit 35%). The median PFS and OS from relapse were 5 and 7 months, respectively; survival rate at 6 months was 58.7 % with an OS at 1 year of 26.7 %. No differences were observed between the two schedules of chemotherapy. Conclusions: These data suggest that chemotherapy plus LD-FRT as second-line treatment is safe and well tolerated, encouraging the prosecution of the study.
Assembly of Alzheimer‐like filaments from full‐length tau protein (1994)

The principal fibrous component of neurofibrillary pathology in Alzheimer's disease, the paired helical filament, is formed from hyperphosphorylated microtubule-associated protein tau. Here we show that recombinant tau protein either in a non-phosphorylated state or following phosphorylation with brain extract can be assembled in vitro into filaments resembling those seen in Alzheimer's disease.