gebhart/patrepeval huggingface dataset:
Measures of clinical efficacy. III. The value of the lung scan in the evaluation of young patients with pleuritic chest pain. (1976)

The usefulness of various modalities in evaluating pleuritic pain in young patients and in isolating cases of pulmonary embolism was assessed using likelihood ratios and the receiver operating characteristic (ROC) curve. History and physical, laboratory, and radiographic finding were used disjunctively to establish an ROC curve. The percentage of patients found to have pulmonary embolism increased monotonically with certain critical pieces of diagnostic data. For example, a history and physical examination alone detected 80% of patients with pulmonary embolism; a chest radiograph raised the percentage to 95%; and the addition of a lung scan increased the percentage to 100%. Thus, with proper interpretation of clinical and radiographic data, the lung scan has only a marginal impact upon the sensitivity with which pulmonary embolism is detected. Its major value is an increased specificity in the diagnosis of pulmonary embolism.
RmtF, a New Member of the Aminoglycoside Resistance 16S rRNA N7 G1405 Methyltransferase Family (2012)

Multidrug-resistant clinical isolate Klebsiella pneumoniae BM4686 was highly resistant to 4,6-disubstituted 2-deoxystreptamines and to fortimicin. Resistance was due to the presence, on the 40-kb non-self-transferable plasmid pIP849, of the rmtF gene which was cotranscribed with the upstream aac(6')-Ib gene. The deduced RmtF protein had 25 to 46% identity with members of the N7 G1405 family of aminoglycoside resistance 16S rRNA methyltransferases.
Technoeconomic Assessment of an Advanced Aqueous Ammonia-Based Postcombustion Capture Process Integrated with a 650-MW Coal-Fired Power Station (2016)

Using a rigorous, rate-based model and a validated economic model, we investigated the technoeconomic performance of an aqueous NH<sub>3</sub>-based CO<sub>2</sub> capture process integrated with a 650-MW coal-fired power station. First, the baseline NH<sub>3</sub> process was explored with the process design of simultaneous capture of CO<sub>2</sub> and SO<sub>2</sub> to replace the conventional FGD unit. This reduced capital investment of the power station by US$425/kW (a 13.1% reduction). Integration of this NH<sub>3</sub> baseline process with the power station takes the CO<sub>2</sub>-avoided cost advantage over the MEA process (US$67.3/tonne vs US$86.4/tonne). We then investigated process modifications of a two-stage absorption, rich-split configuration and interheating stripping to further advance the NH<sub>3</sub> process. The modified process reduced energy consumption by 31.7 MW/h (20.2% reduction) and capital costs by US$55.4 million (6.7% reduction). As a result, the CO<sub>2</sub>-avoided cost fell to $53.2/tonne: a savings of $14.1 and $21.9/tonne CO<sub>2</sub> compared with the NH<sub>3</sub> baseline and advanced MEA process, respectively. The analysis of energy breakdown and cost distribution indicates that the technoeconomic performance of the NH<sub>3</sub> process still has great potential to be improved.
Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer (2010)

Herein we chronicle the discovery of CX-4945 (25n), a first-in-class, orally bioavailable ATP-competitive inhibitor of protein kinase CK2 in clinical trials for cancer. CK2 has long been considered a prime cancer drug target because of the roles of deregulated and overexpressed CK2 in cancer-promoting prosurvival and antiapoptotic pathways. These biological properties as well as the suitability of CK2's small ATP binding site for the design of selective inhibitors, led us to fashion novel therapeutic agents for cancer. The optimization leading to 25n (K(i) = 0.38 nM) was guided by molecular modeling, suggesting a strong binding of 25n resulting from a combination of hydrophobic interactions, an ionic bridge with Lys68, and hydrogen bonding with the hinge region. 25n was found to be highly selective, orally bioavailable across species (20-51%) and efficacious in xenograft models. The discovery of 25n will allow the therapeutic targeting of CK2 in humans for the first time.
Hepatic carbohydrate metabolism in the spontaneously diabetic Bio-Breeding Worcester rat (1981)

The effects of diabetes on hepatic carbohydrate metabolism were investigated in spontaneously diabetic Bio-Breeding Worcester (BB/W) rats. The juvenile-onset-type syndrome displayed by these animals is characterized by beta-cell destruction with subsequent ketosis-prone insulinopenia. Livers from diabetic animals demonstrated increased adenosine 3',5'-cyclic monophosphate levels but subnormal total protein and glycogen content. Isolated perfused livers of diabetic BB/W rats demonstrated an increased rate of glucose production from [14C]lactate and an impaired rate of glycogen synthesis. These data were consonant with hepatic enzyme studies demonstrating markedly increased activities of component gluconeogenic (glucose-6-phosphatase, fructose-1,6-diphosphatase, phosphoenolpyruvate carboxykinase) and glycogenolytic (glycogen phosphorylase) enzymes with decreased activities of glycolytic (hexokinase, pyruvate kinase) and glycogenic (glycogen synthase) enzymes. These findings agree with previous studies using alloxan- and streptozotocin-induced diabetic animals and suggest that accelerated hepatic gluconeogenesis and impaired glucose utilization are pathognomonic of all insulin-deficient diabetic syndromes.
Screening of sleep apnea based on heart rate variability and long short-term memory (2021)

Since the RRI data can be easily measured by means of wearable heart rate sensors, our method may prove to be useful as an SAS screening system at home.
Multipartite RRTs for Rapid Replanning in Dynamic Environments (2007)

The rapidly-exploring random tree (RRT) algorithm has found widespread use in the field of robot motion planning because it provides a single-shot, probabilistically complete planning method which generalizes well to a variety of problem domains. We present the multipartite RRT (MP-RRT), an RRT variant which supports planning in unknown or dynamic environments. By purposefully biasing the sampling distribution and re-using branches from previous planning iterations, MP-RRT combines the strengths of existing adaptations of RRT for dynamic motion planning. Experimental results show MP-RRT to be very effective for planning in dynamic environments with unknown moving obstacles, replanning in high-dimensional configuration spaces, and replanning for systems with space time constraints.
DFIG control performance under fault conditions for offshore wind applications (2005)

Fault ride-through is a key issue for Doubly Fed Induction Generators (DFIGs) used in wind turbine generators. A detailed simulation of the DFIG is used to demonstrate the control issues associated with specific balanced and unbalanced network fault conditions and contrasts this with user experience. The standard DFIG scheme is shown to be unlikely to comply with transmission system operator regulations. The work presented is part of an ongoing investigation into cost-effective solutions. for DFIG fault ride-through.
3D visualization of dislocation arrangement using scanning electron microscope serial sectioning method (2015)

We performed the three-dimensional visualization of dislocations through serial sectioning and use of SEM electron channeling contrast (ECC) images for a crept nickel-based alloy. We successfully reconstructed a volume of approximately 7.5 μm3, including dislocation arrangements, by performing calculations based on the continuous tomograms of ECC images. By incorporating the information on crystal orientation obtained by the electron back-scattered diffraction, we verified that the three-dimensional arrangement of dislocations, such as slip plane, was accurately reflected in the three-dimensional volume.
Changes in Electrical Resistivity during Continuous Heating of Cu-13at.%Pt Alloys Quenched from Various Temperatures (2004)

The changes in electrical resistivit.y during continuous heating of Cu-13at.%Pt alloys with L12 type structure, annealed at various temperatures and immediately quenched, are carefully examined and the relationships between the residual resistivity and the temperature coefficient of resistivity and the order parameter deduced from differential scanning calorimetory are experimentally investigated. The results are compared with those for Cu3Pd alloys with the same ordered structure, previously reported. The electrical measurement reveals that the electrical resistivity increases just below the order-disorder transition temperature in the same way as that of Cu3Pd alloys, but the relative magnitude of this increase with respect to the total change upon ordering is smaller than in Cu3Pd alloys. It is also found that the resistivity change during heating deduced from the thermal behaviour using an experimental equation derived here, agrees sufficiently well with the results of measurement.
Interactive humanoid robots for a science museum (2006)

This paper reports on a field trial with interactive humanoid robots at a science museum where visitors are supposed to study and develop an interest in science. In the trial, each visitor wore an RFID tag while looking around the museum's exhibits. Information obtained from the RFID tags was used to direct the robots' interaction with the visitors. The robots autonomously interacted with visitors via gestures and utterances resembling the free play of children [1]. In addition, they performed exhibit-guiding by moving around several exhibits and explaining the exhibits based on sensor information. The robots were highly evaluated by visitors during the two-month trial. Moreover, we conducted an experiment in the field trial to compare the detailed effects of exhibit-guiding and free-play interaction under three operating conditions. This revealed that the combination of the free-play interaction and exhibit-guiding positively affected visitors' experiences at the science museum.
Comparison of TIDI Wind Observations and the HWM07 Model (2008)

•The Horizontal Wind Model 07 (HWM07) is a newempirical atmospheric wind model [see poster 1540].A variety of ground and space-based data sourceswere included, but notably not data from the TIMEDDoppler Interferometer (TIDI). TIDI has measuredmesosphere, lower thermosphere winds since early2002. This poster presents a comparison of the windsmeasured by TIDI and modeled by HWM07.
The Hancock Amendment and the Increasing Burden on Missouri Environmental Programs. Missouri Municipal League v. State (1997)

Id3 "Hancock Amendment" is the popular name of article X, sections 16-24 ofthe Missouri Constitution, attributed to Missouri legislator Mel Hancock, who proposed the amendment.Section 21 in particular is at issue in the present case. 4
Analyzing Well Production Data Using Combined Type Curve and Decline Curve Analysis Concepts (1998)

Abstract This paper presents new production decline curves for analyzing well production data from radial and vertically fractured oil and gas wells. These curves have been developed by combining Decline curve and Type curve analysis concepts to result in a practical tool which we feel can more easily estimate the gas (or oil) in place as well as to estimate reservoir permeability, skin effect, fracture length and conductivity, etc. Accuracy of this new method has been verified with numerical simulations and the methods have been used to perform analyses using production data from several different kinds of gas wells. Field and simulated examples are included to demonstrate the applicability and versatility of this technology. Decline curve analysis methods, in a variety of forms, have been used in the petroleum industry for more than fifty years to analyze production data and forecast reserves. Type curve analysis methods have become popular, during the last thirty years, to analyze pressure transient test (e.g. buildup, draw-down) data. Pressure transient data can be costly to obtain and may not be available for many wells, while well production data is routinely collected and is even available from industry data bases. In the absence of pressure transient data, a method that cause readily available well production data to perform pressure transient analysis would be very beneficial. The result is the development of these new production decline type curves. These new production decline type curves represent an advancement over previous work because a clearer distinction can be made between transient and boundary dominated flow periods. The new curves also contain derivative functions, similar to those used in the pressure transient literature to aid in the matching process. These production decline curves are, to our knowledge, the first to be published in this format specifically for hydraulically fractured wells of both infinite and finite conductivity. Finally, these new curves have been extended to utilize cumulative production data in addition to commonly used rate decline data. P. 585
Quasi–Lamé–Mode Quartz–Crystal Resonators (2000)

In this paper, quasi-Lamé-mode quartz-crystal resonators formed by etching processes are examined theoretically and experimentally. First, the frequency equation for a Y-plate quartz-crystal resonator is derived by the energy method. Then, the relationship between the cut angles φ y and θ y to vibrate the quasi-Lamé mode is investigated. There are many combinations of φ y and θ y for which the first-order temperature coefficient α becomes zero. Finally, it is theoretically and experimentally demonstrated that the temperature characteristics of a Y-plate quasi-Lamé-mode quartz-crystal resonator is superior to that of a pure-Lamé-mode resonator.
Imaging dataset of fresh hydrous plants obtained by field-emission scanning electron microscopy conducted using a protective NanoSuit (2020)

Although scanning electron microscopy (SEM) can generate high-resolution images of nanosized objects, it requires a high vacuum to do so, which precludes direct observations of living organisms and often produces unwanted structural changes. It has previously been reported that a simple surface modification gives rise to a nanoscale layer, termed the "NanoSuit", which can keep small animals alive under the high vacuum required for field-emission scanning electron microscopy (FE-SEM). We have previously applied this technique to plants, and successfully observed healthy petals in a fully hydrated state using SEM. The flower petals protected with the NanoSuit appeared intact, although we still lack a fundamental understanding of the images of other plants observed using FE-SEM. This report presents and evaluates a rich set of images, acquired using the NanoSuit, for a taxonomically diverse set of plant species. This dataset of images allows the surface features of various plants to be analyzed and thus provides a further complementary morphological profile. Image data can be accessed and viewed through Figshare (https://doi.org/10.6084/m9.figshare.c.4446026.v1).
Dynamic frequency allocation in fractional frequency reused OFDMA networks (2009)

This paper proposes a dynamic fractional frequency reused cell architecture that simplifies the problem of subcarrier allocation with frequency reuse in multicell OFDMA networks. The architecture divides the cell surface into two overlapping geographical regions and orthogonally allocates subcarriers, which are called super and regular group of subcarriers, to the regions. The proposed architecture allows a frequency reuse factor of 1 with reduced inter-cell interference and increased trunking gain, while satisfying minimum data rate requirements. We also propose an efficient hierarchical solution to realize the proposed architecture. The solution first allocates subcarriers to the groups so that long term performance is maximized and next opportunistically schedules subcarriers to the users. The opportunistic scheduling is performed at the base stations considering the fairness requirements of the users. Simulation results illustrate the performance improvements of the proposed solution in comparison to the traditional frequency allocation schemes.
A close range digital photogrammetry system (1990)

Recent developments of video cameras and frame grabber technology have led photogrammetrists into the fields of digital image processing and machine vision. This paper describes the components of a digital photogrammetric system for close range applications. The approach to image matching involves the location of preliminary matched details based on features which are used as initial approximations to determination of precisely matched areas on the two images. Image matching based on grey scale values uses the least squares matching method. A software package has been developed to determine object geometry from overlapping digital images, and results from test are presented for three combinations of base/height ratio. Future developments will be based on the use of a knowledge base to control the searching for matched points.
Fabrication of Al/sub 2/O/sub 3/ and AlN thin films by reactive sputtering and its optimization using DOE (2005)

Thin films of Al/sub 2/O/sub 3/ and AlN have been fabricated by reactive sputtering using magnetron sputtering equipment. A mixture of Ar and O/sub 2/ has been used for the fabrication of Al/sub 2/O/sub 3/ films, and a mixture of Ar and N/sub 2/ has been used for the fabrication of AlN films. Optimization of the fabrication process has been carried out using DOE (design of experiments). Experiments of the type 2/sup 3/ have been used for creating mathematical models of sputtering processes. The results calculated from the models have been compared with the results obtained during the fabrication process. It has been found that there is very good coincidence between the results calculated from the mathematical model and measured on fabricated layers.
Corticosterone Levels in the Brain Show a Distinct Ultradian Rhythm but a Delayed Response to Forced Swim Stress (2008)

Circulating corticosterone levels show an ultradian rhythm resulting from the pulsatile release of glucocorticoid hormone by the adrenal cortex. Because the pattern of hormone availability to corticosteroid receptors is of functional significance, it is important to determine whether there is also a pulsatile pattern of corticosterone concentration within target tissues such as the brain. Furthermore, it is unclear whether measurements of plasma corticosterone levels accurately reflect corticosterone levels in the brain. Given that the hippocampus is a principal site of glucocorticoid action, we investigated in male rats hippocampal extracellular corticosterone concentrations under baseline and stress conditions using rapid-sampling in vivo microdialysis. We found that hippocampal extracellular corticosterone concentrations show a distinct circadian and ultradian rhythm. The PULSAR algorithm revealed that the pulse frequency of hippocampal corticosterone is 1.03 +/- 0.07 pulses/h between 0900 and 1500 h and is significantly higher between 1500 and 2100 h (1.31 +/- 0.05). The hippocampal corticosterone response to stress is stressor dependent but resumes a normal ultradian pattern rapidly after the termination of the stress response. Similar observations were made in the caudate putamen. Importantly, simultaneous measurements of plasma and hippocampal glucocorticoid levels showed that under stress conditions corticosterone in the brain peaks 20 min later than in plasma but clears concurrently, resulting in a smaller exposure of the brain to stress-induced hormone than would be predicted by plasma hormone concentrations. These data are the first to demonstrate that the ultradian rhythm of corticosterone is maintained over the blood-brain barrier and that tissue responses cannot be reliably predicted from the measurement of plasma corticosterone levels.
Novel graph-theoretical approach to ring-transformation reactions: hierarchic classification and computer design of heterocyclic rearrangements (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel graph-theoretical approach to ring-transformation reactions: hierarchic classification and computer design of heterocyclic rearrangementsEugeny V. Babaev, Dmitry E. Lushnikov, and Nikolai S. ZefirovCite this: J. Am. Chem. Soc. 1993, 115, 6, 2416–2427Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/ja00059a042https://doi.org/10.1021/ja00059a042research-articleACS PublicationsRequest reuse permissionsArticle Views172Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid (2015)

Release of active PAD isoforms into the SF by neutrophil cell death is a plausible explanation for the generation of extracellular autoantigens in RA.
A novel EEG-based detection method of emergency situations for assistive vehicles (2017)

This paper presents a new Electroencephalography (EEG)-based method to detect emergency situations while drivers employ a brain-machine interface but not using limbs to operate an assistive vehicle. EEG signals were first preprocessed to remove the blinking artifact. The sums of powers of five rhythms (including alpha, delta, beta, theta, and low gamma rhythms) from 16 channels were then computed as the original feature pool. After that, Chi-square feature extraction method was employed to select features as the input of the Fisher linear classifier. The experimental results indicate that the proposed model can issue a braking command 400ms earlier than drivers with the system accuracy of 91.72% on average. The new detection model can be used to help develop a complementary driver assistant system to existing ones to improve the safety of brain-controlled driving and even driving with limbs.
Potent and Selective Non-Cysteine-Containing Inhibitors of Protein Farnesyltransferase (1998)

Potent and selective non-thiol-containing inhibitors of protein farnesyltransferase are described. FTI-276 (1) was transformed into pyridyl ether analogue 19. The potency of pyridyl ether 19 was improved by modification of the biphenyl core to that of an o-tolyl substituted biphenyl core to give 29. In addition to 0.4 nM in vitro potency, 29 displayed 350 nM potency in whole cells as the parent carboxylic acid. The o-tolyl biphenyl core dramatically and unexpectedly enhanced the potency of other compounds as exemplified by 46, 47, 48, and 49.