gebhart/patrepeval huggingface dataset:
Stacked Low-Inertia Converter or Solid-State Transformer: Modeling and Model Predictive Priority-Shifting Control for Voltage Balance (2021)

This article presents control challenges of stacked low-inertia converter (SLIC) or cascaded reduced dc-link solid-state transformer (SST) and proposes a novel model predictive priority-shifting (MPPS) control with implicit modulator and a discrete-time large-signal model for voltage balancing and dc-link regulation. Low-inertia converters, featuring small electrolytic capacitor-less dc links, dramatically reduce cost, size, and weight compared to conventional solutions. However, without a large dc-link buffer, the input and output are tightly coupled, leading to significant control challenges. The control becomes even more challenging with these converters stacked input-series output-parallel (ISOP) for medium-voltage (MV) grid, which causes coupling between the modules besides the coupling within each module. This article analyzes the multiobjective, multidegree of freedom control problem, using the modular soft-switching solid-state transformer (M-S4T) as an example of the SLIC. First, distribution of control efforts under controller saturation is critical because multiple control objectives can be conflicting, especially when the module voltages are unbalanced and are being restored. The MPPS can shift the priorities to address this issue. Second, due to the low inertia and high dc-link ripple, classic space vector pulsewidth modulation, average model with small-ripple assumption, and control design based on small-signal model cannot accurately modulate, model, and control the nonlinear reduced dc link. Therefore, a discrete-time large-signal model of the M-S4T is established to derive the predictive control in the MPPS. The MPPS and the PI control are compared in MV simulations to show the issue of applying the PI to the SLIC and the effectiveness of the MPPS for voltage balancing and dc-link regulation in a deadbeat manner. Finally, the proposed control is tested on a 5-kV ISOP SiC SST prototype to verify priority shifting to address controller saturation issue and fast and robust voltage balancing.
High Throughput Technologies to Break the Biological Barriers to Cellulosic Fuels (2009)

Author(s): Hadi, Masood Z.; Tran, Huu; Morrison, Stephanie; Chu, Hou Cheng; DeGiovanni, A.; Adams, Paul D.
Supplementary Figure S1 from <i>(R)</i>-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in <i>IDH</i>-Mutant Cancers (2023)

&lt;p&gt;Characterization of isogenic TF-1 cell lines expressing TET2-targeting shRNAs.&lt;/p&gt;
Incident and prevalent cohorts with pulmonary arterial hypertension: insight from SERAPHIN (2015)

In SERAPHIN, a long-term, randomised, controlled trial (NCT00660179) in pulmonary arterial hypertension (PAH), macitentan significantly reduced the risk of morbidity/mortality and PAH-related death/hospitalisation. We evaluated disease progression and the effect of macitentan in treatment-naïve incident and prevalent cohorts.Patients allocated to placebo, or macitentan 3 mg or 10 mg were classified by time from diagnosis to enrolment as incident (≤6 months; n=110) or prevalent (>6 months; n=157). The risk of morbidity/mortality and PAH-related death/hospitalisation was determined using Cox regression.The risk of morbidity/mortality (Kaplan-Meier estimates at month 12: 54.4% versus 26.7%; p=0.006) and PAH-related death/hospitalisation (Kaplan-Meier estimates at month 12: 47.3% versus 19.9%; p=0.006) were significantly higher for incident versus prevalent patients receiving placebo, respectively. There was no significant difference in the risk of all-cause death between incident and prevalent cohorts (p=0.587). Macitentan 10 mg significantly reduced the risk of morbidity/mortality and PAH-related death/hospitalisation versus placebo in incident and prevalent cohorts.Incident patients had a higher risk for PAH progression compared with prevalent patients but not a higher risk of death. Macitentan delayed disease progression in both incident and prevalent PAH patients.
Improving Data Transmission in Fiber Optics by Detecting Scratches on the Fiber End Face (2018)

Optical fiber sustains scratches, pits and other types of defects on the end face during the polishing process. Hence, fiber end face inspection is a significant process for fiber manufacturers when analysing the performance of a fiber. In order to identify the defects present on the fiber end face, a novel model is presented in this paper. Our model combined filtering methods to enhance the contrast of the images so scratches can be successfully detected. However, because the photos have been taken with different gains and exposures, they can not be processed with standard image processing techniques. We developed a method to analyse the defects intensity that could be located under different gains and exposures. We established that the images taken with the high gains and exposures performed well for optical fiber defect recognition.
Synthesis of Cu nanoparticles in mesoporous silica SBA-15 functionalized with carboxylic acid groups (2010)

In this study, the mesoporous silica SBA-15 materials containing carboxylic acid groups were used as an effective support to synthesize Cu nanoparticles. Various Cu loading levels from 4% to 13% on SBA-15 catalysts produced an average particle size of 2.8 to 3.1 nm, regardless of the Cu content.
Dynamics of Phosphorylation and Assembly of the High Molecular Weight Neurofilament Subunit in NB2a/d1 Neuroblastoma (1990)

In neuronal systems thus far studied, newly synthesized neurofilament subunits rapidly associate with the Triton-insoluble cytoskeleton and subsequently undergo extensive phosphorylation. However, in the present study we demonstrate by biochemical and immunological criteria that NB2a/d1 neuroblastoma cells also contain Triton-soluble, extensively phosphorylated 200-kDa high molecular weight neurofilament subunits (NF-H). High-speed centrifugation (100,000 g) of the Triton-soluble fraction for 1 h sedimented some, but not all, soluble NF-H subunits; immunoelectron microscopic analyses of the resulting pellet indicated that a portion of the NF-H subunits in this fraction are assembled into (Triton-soluble) neurofilaments. When cells were pulse labeled for 15 min with [35S]methionine, radiolabel was first associated with the Triton-soluble 200-kDa NF-H variants. Because only extensively phosphorylated NF-H subunits migrate at 200 kDa, whereas hypophosphorylated subunits migrate instead at 160 kDa, these findings suggest that some newly synthesized subunits were phosphorylated before they polymerized. In pulse-chase analyses, radiolabeled 200-kDa NF-H migrated into the 100,000 g particulate fraction of Triton-soluble extracts before its arrival in the Triton-insoluble cytoskeleton. Undifferentiated cells, which do not possess axonal neurites and lack a significant amount of Triton-insoluble, extensively phosphorylated NF-H, contain a sizeable pool of Triton-soluble extensively phosphorylated NF-H subunits and polymers. We interpret these data to indicate that the integration of newly synthesized NF-H into the cytoskeleton occurs in a progression of distinct stages, and that assembly of NF-H into neurofilaments and integration into the Triton-insoluble cytoskeleton are not prerequisites for the incorporation of certain phosphate groups on these polypeptides.(ABSTRACT TRUNCATED AT 250 WORDS)
First‐line antiretroviral therapy with efavirenz plus tenofovir disiproxil fumarate/emtricitabine or rilpivirine plus tenofovir disiproxil fumarate/emtricitabine: a durability comparison (2018)

In our nonrandomized comparison, RPV was better tolerated, less toxic and showed longer durability than EFV, without a significant difference in rates of discontinuation because of failures.
Towards phase transferable potential functions: Methodology and application to nitrogen (1995)

We describe a generalizable approach to the development of phase transferable effective intermolecular potentials and apply the method to the study of N2. The method is based on a polarizable shell model description of the isolated molecule and uses experimental data to establish the parameters. Consideration of the Ne dimer shows this to be a conceptual advance over point polarizability descriptions of atomic interaction. Our parametrization of N2 accurately describes not only the molecule’s electrostatic field (i.e., a practical representation of the molecular charge distribution) but also its response to electrical and mechanical stress (polarization and deformation). The purely intermolecular terms in our potential reflect shell-shell interactions. These are parametrized by fitting properties of the low temperature solid phase of nitrogen. We derive a phase transferable potential able to account for the second virial coefficient of the gas phase, the pressure induced phase transition between nitrogen’s cubic and tetragonal phases, and a wide range of liquid properties (pair distribution function, heat of vaporization, self-diffusion coefficient and dielectric constant).
Demand-Driven Care and Hospital Choice. Dutch Health Policy Toward Demand-Driven Care: Results from a Survey into Hospital Choice (2008)

In the Netherlands, current policy opinion emphasizes demand-driven health care. Central to this model is the view, advocated by some Dutch health policy makers, that patients should be encouraged to be aware of and make use of health quality and health outcomes information in making personal health care provider choices. The success of the new health care system in the Netherlands is premised on this being the case. After a literature review and description of the new Dutch health care system, the adequacy of this demand-driven health policy is tested. The data from a July 2005, self-administered questionnaire survey of 409 patients (response rate of 94%) as to how they choose a hospital are presented. Results indicate that most patients did not choose by actively employing available quality and outcome information. They were, rather, referred by their general practitioner. Hospital choice is highly related to the importance a patient attaches to his or her physician's opinion about a hospital. Some patients indicated that their hospital choice was affected by the reputation of the hospital, by the distance they lived from the hospital, etc. but physician's advice was, by far, the most important factor. Policy consequences are important; the assumptions underlying the demand-driven model of patient health provider choice are inadequate to explain the pattern of observed responses. An alternative, more adequate model is required, one that takes into account the patient's confidence in physician referral and advice.
Driving behavior analysis using vision-based head pose estimation for enhanced communication among traffic participants (2013)

We propose a scheme to evaluate driver behaviors by a vision-based head pose estimation method. In our project, we are investigating a collaborative safety mechanism based on the mutual sharing of driver information (attention and performance) in daily situations. The analysis of driver behaviors based on a non-contact type of measurement is one key issue in our mechanism. In this paper, we describe a voting-based head pose estimation algorithm and several driving behavior analysis results using our method. We also address examples of graphical representations for driver information sharing that directly correspond to the extracted driving behaviors.
A fast two-pass HDL simulation with on-demand dump (2008)

Simulation-based functional verification is characterized by two inherently conflicting targets: the signal visibility and simulation performance. Achieving a proper trade-off between these two targets is of paramount importance. Even though HDL simulators are the most widely used verification platform at the RTL and gate level, their major drawback is the low performance in verifying complex SOCs, especially when the high visibility over the design under verification is required. This paper presents a new, fast simulation method as an effective way to achieve both high simulation speed and full signal visibility. It is based on an original two-pass simulation approach. During the 1 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> pass, with the simulation running at full speed, a set of design states is saved periodically at predetermined checkpoints. During the 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> pass, another simulation is performed, using any of saved checkpoints and providing 100% signal visibility for debugging. Our method differs from the traditional simulation snapshot approach in the amount and the way the design state is saved. Experimental results show significant speed-up compared to existing traditional simulation methods while maintaining 100% visibility.
An enzyme releasing lacto-N-biose from oligosaccharides. (1992)

alpha-L-Fucosidase (alpha-L-fucoside fucohydrolase; EC 3.2.1.51) preparations from Streptomyces sp. 142 were found to contain an enzyme specific for lacto-N-biosidic (Gal beta 1-3GlcNAc beta 1-) linkages (type 1 structure) in oligosaccharides. The enzyme preparation, which was eluted after alpha-fucosidase from a CM-Sepharose column, contained some alpha-fucosidase activity but was free from other glycosidases and proteases. Substrate specificity studies with oligosaccharides labeled with 2-aminopyridine showed that the enzyme specifically hydrolyzed lacto-N-tetraose (Gal beta 1-3GlcNAc beta 1-3Gal beta 1-4Glc) but did not hydrolyze lacto-N-neotetraose (Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc), lacto-N-triose, sialyl lacto-N-tetraose, lacto-N-fucopentaose I, II, or III, asialo-GM1 tetrasaccharide, or poly-N-acetyllactosamine. Structural analysis of the enzyme digest of the N-acetyllactosamine type of triantennary sugar chain with type 1 structure showed that lacto-N-biose (Gal beta 1-3GlcNAc) and the N-acetyllactosamine type of biantennary sugar chain were produced. Thus this enzyme was tentatively named lacto-N-biosidase, because it hydrolyzes oligosaccharides containing a type 1 structure at the nonreducing terminus and produces lacto-N-biose.
A theoretical framework for memory-adaptive algorithms (2003)

External memory algorithms play a key role in database management systems and large scale processing systems. External memory algorithms are typically tuned for efficient performance given a fixed, statically allocated amount of internal memory. However, with the advent of real-time database system and database systems based upon administratively defined goals, algorithms must increasingly be able to adapt in an online manner when the amount of internal memory allocated to them changes dynamically and unpredictably. We present a theoretical and applicable framework for memory-adaptive algorithms (or simply MA algorithms). We define the competitive worst-case notion of what it means for an MA algorithm to be dynamically optimal and prove fundamental lower bounds on the performance of MA algorithms for problems such as sorting, standard matrix multiplication, and several related problems. Our main tool for proving dynamic optimality is the notion of resource consumption, which measures how efficiently an MA algorithm adapts itself to memory fluctuations. We present the first dynamically optimal algorithm for sorting (based upon mergesort), permuting, FFT, permutation networks, buffer trees, (standard) matrix multiplication, and LU decomposition. In each case, dynamic optimality is demonstrated via a potential function argument showing that the algorithm's resource consumption is within a constant factor of optimal.
Use of Oscillatory Deformation Technique to Determine Clotting Times and Rigidities of Milk Clotted with Different Concentrations of Rennet (1982)

ABSTRACT A curd firmness tester that measures rigidity of gels subjected to oscillatory deformation was used to determine clotting times and gel rigidities (G) of milk treated with different concentrations of rennet. Clotting times were directly related to reciprocal of enzyme concentrations. Increases in gel rigidity quite closely obeyed the relationship G = Ge‐λ/t where λ is the time to attain a value of G/e and t is the time subsequent to clotting. Rates of increases in rigidity during the first half of gel assembly were increased by increases in rennet concentration but maximum gel rigidity (G) was not affected.
ChemInform Abstract: RESOLUTION AND ABSOLUTE CONFIGURATION OF BICYCLO(3.3.0)OCTA‐2,6‐DIENE‐2‐CARBOXYLIC ACID (1983)

Abstract Bicyclo13,3,0]octa‐2,o‐dien‐2‐carbonsäure (Ia) wird über ein mit dem Phenethylamin (II) gebildetes Salz in die Antipoden (Ib) und (Ic) getrennt.
Allelic heterogeneity of Crooked Tail Syndrome: result of balancing selection? (2012)

We report the identification of a second loss-of-function mutation (c.1906T>C) in the bovine MRC2 gene causing the Crooked Tail Syndrome in Belgian Blue Cattle. We demonstrate that the ensuing substitution of the highly conserved Cysteine 636 with Arginine causes illegitimate receptor oligomerization, which is predicted to impair function of the MRC2 encoded protein, Endo180. We propose that this second MRC2 mutation was selected by breeders as a result of its favourable effect on muscularity in heterozygotes.
Construction and usage of time-limited keys in secure multimedia distribution (2008)

If the results of the latest studies for Internet usage are to be believed, worldwide 12 million TV consumers will be using Internet protocol TV (IPTV) instead of the traditional TV broadcasting by the year 2010. These figures were published by ABI Research in 2006. Furthermore, analysts of Informa Telecoms & Media are forecasting the worldwide grow in revenue of IPTV to be ten billion dollar by 2010. The revolution that is described by these figures implies on the one hand an enormous increase in sales values but on the other hand causes problems in handling the data volume. Moreover, IPTV will be attracting criminal attacks like Pay-TV has in traditional broadcasting. Therefore, not only efficient encoding of media data has to be applied to save transmission capacity but also security mechanisms should be established to prevent unauthorised access. This paper will give a short overview of possible infrastructure setup as well as a method for the use of time-limited keys.
Automatic profiled fiber identification based on a sequential clustering algorithm (2011)

Automatic profiled fiber identification is of very significance to textiles quality control and performance design. In this paper, we present a facile sequential clustering algorithm used for profiled fiber identification. This clustering algorithm is based on dissimilarity measures between feature vectors. One of its advantages is that the final result is independent on the order in which the vectors are presented to the algorithm. Our profiled fiber identification system employs a feature extracting technique that uses the shape information residing in the boundary curve of profiled fiber cross-sections. The experimental results show that the defined shape descriptor and the classification method can effectively identify solid profiled fibers that differ in their cross sectional shapes.
Quality Aspects of Insects as Food—Nutritional, Sensory, and Related Concepts (2019)

In the search for another appealing source of future food to cover the increasing need for nutrients of a growing global population, this study reviewed the potential of insects as human food. Most previous reviews have dealt with insects as a group, making it difficult to evaluate each individual insect species as food because of the generalized data. This study assessed some common edible insects, but concentrated on mealworms. Insects, especially mealworms, have a similar or higher nutritional value than many conventional food sources. For example, the protein content of mealworm larvae is reported to be almost 50% of dry weight, while the fat content is about 30% of larval dry weight. Mealworms can be cooked by different methods, such as hot air drying, oven broiling, roasting, pan frying, deep frying, boiling, steaming, and microwaving. Oven broiling in particular gives a desirable aroma of steamed corn for consumers. Changes in the flavor, taste, and texture of mealworm products during storage have not been studied, but must be determined before mealworms can be used as a commercial food source. Factors controlling the shelf-life of mealworms, such as their packaging and storage, should be identified and considered with respect to the feasibility of using mealworms on a commercial scale.
Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect (2017)

These results demonstrated the multi-mediated characteristic of the articular inflammation induced by MT-II, which demonstrates its relevance as a model for arthritis mechanisms and treatment evaluation.
Combined Diffusion Tensor and Magnetic Resonance Spectroscopic Imaging Methodology for Automated Regional Brain Analysis: Application in a Normal Pediatric Population (2017)

During human brain development, anatomic regions mature at different rates. Quantitative anatomy-specific analysis of longitudinal diffusion tensor imaging (DTI) and magnetic resonance spectroscopic imaging (MRSI) data may improve our ability to quantify and categorize these maturational changes. Computational tools designed to quickly fuse and analyze imaging information from multiple, technically different datasets would facilitate research on changes during normal brain maturation and for comparison to disease states. In the current study, we developed a complete battery of computational tools to execute such data analyses that include data preprocessing, tract-based statistical analysis from DTI data, automated brain anatomy parsing from T1-weighted MR images, assignment of metabolite information from MRSI data, and co-alignment of these multimodality data streams for reporting of region-specific indices. We present statistical analyses of regional DTI and MRSI data in a cohort of normal pediatric subjects (&lt;i&gt;n&lt;/i&gt; = 72; age range: 5-18 years; mean 12.7 ± 3.3 years) to establish normative data and evaluate maturational trends. Several regions showed significant maturational changes for several DTI parameters and MRSI ratios, but the percent change over the age range tended to be small. In the subcortical region (combined basal ganglia [BG], thalami [TH], and corpus callosum [CC]), the largest combined percent change was a 10% increase in fractional anisotropy (FA) primarily due to increases in the BG (12.7%) and TH (9%). The largest significant percent increase in N-acetylaspartate (NAA)/creatine (Cr) ratio was seen in the brain stem (BS) (18.8%) followed by the subcortical regions in the BG (11.9%), CC (8.9%), and TH (6.0%). We found consistent, significant (&lt;i&gt;p&lt;/i&gt; &lt; 0.01), but weakly positive correlations (&lt;i&gt;r&lt;/i&gt; = 0.228-0.329) between NAA/Cr ratios and mean FA in the BS, BG, and CC regions. Age- and region-specific normative MR diffusion and spectroscopic metabolite ranges show brain maturation changes and are requisite for detecting abnormalities in an injured or diseased population.