gebhart/patrepeval huggingface dataset:
Chemokine‐receptor expression on T cells in lung compartments of challenged asthmatic patients (2005)

The expression of certain chemokine receptors by lung T cells suggests a contribution to the physiological recruitment of T cells to the lungs, both in healthy controls and unchallenged mild asthmatics. However, strong allergen-induced airway responses were associated with a specific chemokine-receptor profile, suggesting the involvement of certain chemokine receptors in the pathogenesis of allergic bronchial inflammation.
ChemInform Abstract: THIENAMYCIN TOTAL SYNTHESIS. 1. SYNTHESIS OF AZETIDINONE PRECURSORS OF (.+‐.)‐THIENAMYCIN AND ITS STEREOISOMERS (1980)

Abstract Im Zusammenhang mit der Synthese des antibiotisch wirksamen Thienamycins (XIV) werden verschiedene Modellreaktionen beschrieben.
Ceruloplasmin/Hephaestin Knockout Mice Model Morphologic and Molecular Features of AMD (2008)

DKOs have age-dependent iron accumulation followed by retinal degeneration modeling some of the morphologic and molecular features of AMD. Therefore, these mice are a good platform on which to test therapeutic agents for AMD, such as antioxidants, iron chelators, and antiangiogenic agents.
Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264 (2012)

Three new bicyclic depsipeptides, which are related to the previously reported thailandepsins A (<b>1</b>), B (<b>2</b>) and C (<b>3</b>), were discovered from the culture broth of <i>Burkholderia thailandensis</i> E264 when supplemented with amino acid precursors, and were subsequently named as thailandepsins D (<b>4</b>), E (<b>5</b>) and F (<b>6</b>), respectively. Enzyme assays showed that <b>1-6</b> are potent histone deacetylase (HDAC) inhibitors, particularly toward HDAC1 which represents class I human HDACs.
Beyond independence: probabilistic models for query approximation on binary transaction data (2003)

We investigate the problem of generating fast approximate answers to queries posed to large sparse binary data sets. We focus in particular on probabilistic model-based approaches to this problem and develop a number of techniques that are significantly more accurate than a baseline independence model. In particular, we introduce two techniques for building probabilistic models from frequent itemsets: the itemset maximum entropy model and the itemset inclusion-exclusion model. In the maximum entropy model, we treat itemsets as constraints on the distribution of the query variables and use the maximum entropy principle to build a joint probability model for the query attributes online. In the inclusion-exclusion model, itemsets and their frequencies are stored in a data structure, called an ADtree, that supports an efficient implementation of the inclusion-exclusion principle in order to answer the query. We empirically compare these two itemset-based models to direct querying of the original data, querying of samples of the original data, as well as other probabilistic models such as the independence model, the Chow-Liu tree model, and the Bernoulli mixture model. These models are able to handle high-dimensionality (hundreds or thousands of attributes), whereas most other work on this topic has focused on relatively low-dimensional OLAP problems. Experimental results on both simulated and real-world transaction data sets illustrate various fundamental trade offs between approximation error, model complexity, and the online time required to compute a query answer.
Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites (2017)

Tissue-resident memory T cells (TRMs) in mice mediate optimal protective immunity to infection and vaccination, while in humans, the existence and properties of TRMs remain unclear. Here, we use a unique human tissue resource to determine whether human tissue memory T cells constitute a distinct subset in diverse mucosal and lymphoid tissues. We identify a core transcriptional profile within the CD69<sup>+</sup> subset of memory CD4<sup>+</sup> and CD8<sup>+</sup> T cells in lung and spleen that is distinct from that of CD69<sup>-</sup> TEM cells in tissues and circulation and defines human TRMs based on homology to the transcriptional profile of mouse CD8<sup>+</sup> TRMs. Human TRMs in diverse sites exhibit increased expression of adhesion and inhibitory molecules, produce both pro-inflammatory and regulatory cytokines, and have reduced turnover compared with circulating TEM, suggesting unique adaptations for in situ immunity. Together, our results provide a unifying signature for human TRM and a blueprint for designing tissue-targeted immunotherapies.
Copper(I)-Catalyzed Enantioselective Substitution of Allyl Chlorides with Diorganozinc Compounds (1999)

Ferrocenylamines are excellent catalysts for the enantioselective substitution of unsymmetrical allyl chlorides with dialkylzinc compounds in the presence of a copper(I) salt. For example, in the reaction shown in Equation (1), the product is formed with 87 % ee and a S<sub>N</sub> 2':S<sub>N</sub> 2 ratio of 97:3.
Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE (2008)

Genetic and environmental factors are believed to influence development of systemic lupus erythematosus (SLE). Endogenous retroviruses (ERV) correspond to the integrated proviral form of infectious retroviruses, which are trapped within the genome due to mutations. ERV represent a key molecular link between the host genome and infectious viral particles. ERV-encoded proteins are recognized by antiviral immune responses and become targets of autoreactivity. Alternatively, ERV protein may influence cellular processes and the life cycle of infectious viruses. As examples, the HRES-1 human ERV encodes a 28-kDa nuclear autoantigen and a 24-kDa small GTP-ase, termed HRES-1/Rab4. HRES-1/p28 is a nuclear autoantigen recognized by cross-reactive antiviral antibodies, while HRES-1/Rab4 regulates surface expression of CD4 and the transferrin receptor (TFR) through endosome recycling. Expression of HRES-1/Rab4 is induced by the tat gene of HIV-1, which in turn down-regulates expression of CD4 and susceptibility to re-infection by HIV-1. CD4 and the TFR play essential roles in formation of the immunological synapse (IS) during normal T-cell activation by a cognate MHC class II peptide complex. The key intracellular transducer of T-cell activation, Lck, is brought to the IS via binding to CD4. T-cell receptorzeta (TCRzeta) chain binds to the TFR. Abnormal T-cell responses in SLE have been associated with reduced lck and TCRzeta chain levels. HRES-1 is centrally located on chromosome 1 at q42 relative to lupus-linked microsatellite markers and polymorphic HRES-1 alleles have been linked to the development of SLE. 1q42 is one of the three most common fragile sites in the human genome, and is inducible by DNA demethylation, a known mechanism of retroviral gene activation. Molecular mimicry and immunomodulation by a ERV, such as HRES-1, may contribute to self-reactivity and abnormal T and B-cell functions in SLE.
Improving index performance through prefetching (2001)

This paper proposes and evaluate Prefetching B + - Trees (pB + -Trees), which use prefetching to accelerate two important operations on B + -Tree indices: searches and range scans. To accelerate searches, pB + -Trees use prefetching to effectively create wider nodes than the natural data transfer size: e.g., eight vs. one cache lines or disk pages. These wider nodes reduce the height of the B + -Tree, thereby decreasing the number of expensive misses when going from parent to child without significantly increasing the cost of fetching a given node. Our results show that this technique speeds up search and update times by a factor of 1.21-1.5 for main-memory B + -Trees. In addition, it outperforms and is complementary to “Cache-Sensitive B + -Trees.” To accelerate range scans, pB + -Trees provide arrays of pointers to their leaf nodes. These allow the pB + -Tree to prefetch arbitrarily far ahead, even for nonclustered indices, thereby hiding the normally expensive cache misses associated with traversing the leaves within the range. Our results show that this technique yields over a sixfold speedup on range scans of 1000+ keys. Although our experimental evaluation focuses on main memory databases, the techniques that we propose are also applicable to hiding disk latency.
AlGaN Transistors for Digital Logic Applications in High-Temperature Environments. (2021)

Abstract not provided.
Development and validation of HPTLC method for quantitative analysis of 24-methylcycloartenol ferulic acid extracted from rice bran (2014)

To develop, validate simple, precise, selective, and accurate high performance thin layer chromatographic (HPTLC) method for analysis of 24-methylcycloartenol ferulic acid in rice bran oil. The analysis was carried out on aluminum plates precoated with silica gel 60 F254 using toluene: ethyl acetate: methanol (15.0:1.7:3.3, v/v/v) as mobile phase. Developed plate was scanned at 317 nm. Tinidazole was used as internal standard. The retention factor for tinidazole, 24-mCAF and CAF were found to be 0.27 ± 0.02, 0.72 ± 0.02 and 0.79 ± 0.02 respectively. The calibration curve was linear over a range of in the range of 200 – 1400 ng sopt-1 where as the correlation coefficient (r) for the plot was 0.999 for 24-mCAF. The proposed HPTLC method was validated in accordance with ICH guidelines. The HPTLC method was found to be precise, robust, accurate and rapid for quantitative estimation of 24-mCAF in rice bran oil extract.
The unc-8 and sup-40 genes regulate ion channel function in Caenorhabditis elegans motorneurons. (1995)

Two Caenorhabditis elegans genes, unc-8 and sup-40, have been newly identified, by genetic criteria, as regulating ion channel function in motorneurons. Two dominant unc-8 alleles cause motorneuron swelling similar to that of other neuronal types in dominant mutants of the deg-1 gene family, which is homologous to a mammalian gene family encoding amiloride-sensitive sodium channel subunits. As for previously identified deg-1 family members, unc-8 dominant mutations are recessively suppressed by mutations in the mec-6 gene, which probably encodes a second type of channel component. An unusual dominant mutation, sup-41 (lb125), also co-suppresses unc-8 and deg-1, suggesting the existence of yet another common component of ion channels containing unc-8 or deg-1 subunits. Dominant, transacting, intragenic suppressor mutations have been isolated for both unc-8 and deg-1, consistent with the idea that, like their mammalian homologues, the two gene products function as multimers. The sup-40 (lb130) mutation dominantly suppresses unc-8 motorneuron swelling and produces a novel swelling phenotype in hypodermal nuclei. sup-40 may encode an ion channel component or regulator that can correct the osmotic defect caused by abnormal unc-8 channels.
ORDPATHs (2004)

We introduce a hierarchical labeling scheme called ORDPATH that is implemented in the upcoming version of Microsoft® SQL Server™. ORDPATH labels nodes of an XML tree without requiring a schema (the most general case---a schema simplifies the problem). An example of an ORDPATH value display format is "1.5.3.9.1". A compressed binary representation of ORDPATH provides document order by simple byte-by-byte comparison and ancestry relationship equally simply. In addition, the ORDPATH scheme supports insertion of new nodes at arbitrary positions in the XML tree, their ORDPATH values "careted in" between ORDPATHs of sibling nodes, without relabeling any old nodes.
Interconnect fatigue design for terrestrial photovoltaic modules (1982)

Fatigue of solar cell electrical interconnects due to thermal cycling has historically been a major failure mechanism in photovoltaic arrays; the results of a comprehensive investigation of interconnect fatigue that has led to the definition of useful reliability-design and life-prediction algorithms are presented. Experimental data gathered in this study indicate that the classical strain-cycle (fatigue) curve for the interconnect material is a good model of mean interconnect fatigue performance, but it fails to account for the broad statistical scatter, which is critical to reliability prediction. To fill this shortcoming the classical fatigue curve is combined with experimental cumulative interconnect failure rate data to yield statistical fatigue curves (having failure probability as a parameter) which enable: (1) the prediction of cumulative interconnect failures during the design life of an array field; and (2) the unambiguous - i.e., quantitative - interpretation of data from field-service qualification (accelerated thermal cycling) tests. Optimal interconnect cost-reliability design algorithms are derived based on minimizing the cost of energy over the design life of the array field. This procedure yields not only the minimum break-even cost of delivered energy, but also the required degree of interconnect redundancy and an estimate of array power degradation during the design life of the array field. The usefulness of the design algorithms is demonstrated with realistic examples of design optimization, prediction, and service qualification testing.
Лечение детей первого года жизни с косолапостью при артрогрипозе по методу Ponseti. Анализ ближайших результатов (2014)

Immediate results of the treatment of 10 children with clubfoot in children with arthrogryposis by the Ponseti method are presented. They are compared with the results obtained in the children given conservative treatment by different methods.
Homology Modeling Inspired Synthesis of 5-HT2A Receptor Inhibitors: A Diazepine Analogue of the Atypical Antipsychotic JL13 (2017)

An efficient synthetic route to an aza-analogue of JL13 was developed and will allow rapid modifications of the core and synthesis of related libraries.
All-silicon optical temperature sensor based on Multi-Mode Interference (2003)

In this paper we present a novel approach to temperature sensing with optoelectronic devices which relies on the usage of bare silicon as the transducing material. The device is composed by a single mode input waveguide, a MMI region where a number of higher order modes is also allowed to propagate and two output waveguides. The refractive index variation in the MMI section due to temperature shifts induces different phase velocities of the various propagating modes. The position of the input and output waveguides together with the length and width of the MMI section are chosen in order to maximize the sensitivity of the device. Analytical calculations are presented together with BPM simulations aimed to the maximization of the sensitivity of the sensor as a function of its geometries.
Charge state of his 57-asp 102 couple in .BETA.-trypsin: A molecular orbital study. (1982)

The charge state of the His 57-Asp 102 couple in β-trypsin in the acid pH range was studied using the ab initio molecular orbital method. The result was in agreement with the NMR experiments which do not support the charge relay hypothesis proposed by Blow et al. It is remarkable that the charge state of His 57-Asp 102 couple is greatly affected by the environment around the catalytic triad.
Deliverable D4.4 Simulated Coherent Scattering Data From Plasma And Non–Plasma Samples (2017)

Deliverable D4.4 of work package 4 (SIMEX) in EUCALL.
A method of producing high quality oxide and related films on surfaces (1991)

Aluminum oxide or aluminum nitride films were deposited on molecular beam epitaxy (MBE) grown GaAS(100) using a novel cryogenic-based reactive thin film deposition technique. The process involves the condensation of molecular oxygen, ammonia, or other gases normally used for reactive thin film deposition on the substrate before the metal is deposited. The metal vapor is deposited into this layer and reacts with the molecular solid to form the desired compound or a precursor that can be thermally decomposed to generate the desired compound. The films produced by this method are free of impurities, and the low temperatures can be used to control the film and interfacial structure. The process can be easily integrated with existing MBE systems. Ongoing research using the same apparatus suggests that photon or electron irradiation could be used to promote the reactions needed to produce the intended material.
1,1,1,3,3,3‐Hexafluoroisopropanol as a Remarkable Medium for Atroposelective Sulfoxide‐Directed Fujiwara–Moritani Reaction with Acrylates and Styrenes (2015)

Axially chiral biaryls are ubiquitous structural motifs of biologically active molecules and privileged ligands for asymmetric catalysis. Their properties are due to their configurationally stable axis, and therefore, the control of their absolute configuration is essential. Efficient access to atropo-enantioenriched biaryl moieties through asymmetric direct C-H activation, by using enantiopure sulfoxide as both the directing group (DG) and chiral auxiliary, is reported. The stereoselective oxidative Heck reactions are performed in high yields and with excellent atropo-stereoselectivities. The pivotal role of 1,1,1,3,3,3-hexafluoropropanol (HFIP) solvent, which enables a drastic increase in yield and stereoselectivity of this transformation, is evidenced and investigated. Finally, the synthetic usefulness of the herein disclosed transformation is showcased because the traceless character of the sulfoxide DG allows straightforward conversions of the newly accessed, atropopure sulfoxide-biaryls into several differently substituted axially chiral scaffolds.
Synthesis and biological activity of the novel indanedione anticoagulant rodenticides containing fluorine (2016)

Here, 3 fluorinated intermediates of drug were synthesized: (M1), (M2), (M3). Three new anticoagulant rodenticides were designed which were based on 4-hydroxycoumarin or 1,3-indandione, added acute toxicity groups containing fluorine. The structures of synthesized compounds were analyzed and proved by FT-IR spectroscopy and <sup>1</sup>H nuclear magnetic resonance (<sup>1</sup>H-NMR). The compounds were also evaluated for their anticoagulant and acute biologic activity. In addition, both the acute orally toxicity and the feeding indexes of R<sub>1</sub> and R<sub>2</sub> were tested. The result of the experiment proved that the new synthesis of 1, 3 - indan diketone for maternal new anticoagulant rodenticide can replace the current 4 - hydroxyl coumarin as the mother of the second generation anticoagulant rodenticide and 1, 3 - indan diketone for maternal new anticoagulant rodenticides will have a good development prospect.
Thinking about quantity: the intertwined development of spatial and numerical cognition (2015)

There are many continuous quantitative dimensions in the physical world. Philosophical, psychological, and neural work has focused mostly on space and number. However, there are other important continuous dimensions (e.g., time and mass). Moreover, space can be broken down into more specific dimensions (e.g., length, area, and density) and number can be conceptualized discretely or continuously (i.e., natural vs real numbers). Variation on these quantitative dimensions is typically correlated, e.g., larger objects often weigh more than smaller ones. Number is a distinctive continuous dimension because the natural numbers (i.e., positive integers) are used to quantify collections of discrete objects. This aspect of number is emphasized by teaching of the count word sequence and arithmetic during the early school years. We review research on spatial and numerical estimation, and argue that a generalized magnitude system is the starting point for development in both domains. Development occurs along several lines: (1) changes in capacity, durability, and precision, (2) differentiation of the generalized magnitude system into separable dimensions, (3) formation of a discrete number system, i.e., the positive integers, (4) mapping the positive integers onto the continuous number line, and (5) acquiring abstract knowledge of the relations between pairs of systems. We discuss implications of this approach for teaching various topics in mathematics, including scaling, measurement, proportional reasoning, and fractions.
Les pays étrangers (1990)

Tyrer John, Khouzami Victoria, Salamé-Zaarouf Thérèse, Hazoume Antoinette. Les pays étrangers. In: Diplômées, n°152, 1990. Jeanne Chaton. pp. 15-19.
Fabrication of fibrin scaffolds with controlled microscale architecture by a two-photon polymerization–micromolding technique (2012)

Fabrication of three-dimensional (3D) fibrin scaffolds with tightly controllable pore sizes and interconnections has been investigated. The scaffolds were produced using a combination of two-photon polymerization (2PP) and micromolding techniques. Master structures were fabricated by 2PP and regenerated in fibrin by a two-step microreplication procedure. Scanning electron and optical microscopy observations showed that the fibrin scaffolds exhibited a highly porous and interconnected structure. Seeding of endothelial cells in fibrin scaffolds resulted in their directed lining and spreading within network of microreplicated pores, whereas encapsulation of endothelial cells in fibrin gel blocks led to their chaotic and irregular distribution within constructs. These results demonstrate that the 2PP-micromolding technique is suitable for fabrication of complex 3D structures from natural proteins for tissue engineering applications.
Non-invasive in vivo temperature mapping of ultrasound heating using magnetic resonance techniques (1994)

A major problem with conventional methods of measuring heating in vivo is that they are invasive and therefore interfere with heat propagation. A sensitive non-invasive method for temperature measurement using in vivo magnetic resonance spectroscopy (MRS) of the temperature dependent chemical shift of the cobalt (III) nucleus has been developed. Initial experiments demonstrate that this technique can be used to measure ultrasound induced temperature changes in the liver. Tris(ethylenediamine) cobalt (III) trichloride was encapsulated in liposomes and injected into seven rats. Heating was performed using a calibrated unfocused transducer operating at 3.41 MHz. After 5 minutes of CW ultrasound exposure, the chemical shift of the cobalt complex indicated that the temperature rise within the liver was 2.0±1.2°C. This was seen to return to normal upon cessation of heating. The acoustic power was determined in a water bath using a calibrated hydrophone. Theoretical calculations based on the transducer calibration characteristics using the monopole-source solution for estimating tissue temperature increase yielded 2.0°C based on steady state conditions. These results indicate that experimental values agree with the heating theory
The principle of fragmentary spectrum registration for acousto-optical spectrometers based on differential optical absorption spectroscopy (2013)

A new analytical technique, named fragmentary spectrum registration (FSR), with use of acousto-optical spectrometers (AOS’s) is proposed and studied. It is based on the method of differential optical absorption spectroscopy (DOAS) and the unique AOS feature of fast (10 &mu;s) random spectral access (RSA). The technique is the most efficient for objects exhibiting sparse optical spectra. The technique permits a substantial (up to 100 times) reduction of detection time in comparison with the record time of total spectrum and provides the decrease of inaccuracy of quantitative analysis of multicomponent mixtures containing substances with similar spectral features. The results of numerical simulation with use of real spectra detected by the trace gas monitoring system GAOS based on AOS are presented and discussed. The experimental results demonstrate the capabilities of the FSR-technique for the huge reduction of the measurement time or for the decrease of measurement error (up to 2.5 times) when the total measurement time is fixed while concentrations being varied from the environment background up to industrial emissions level.