gebhart/patrepeval huggingface dataset:
A2B Adenosine Receptors Stimulate Release of IL‐6, CXCL1/IL‐8 and Vascular Growth Factor from Cardiac Stromal Cells (2012)

Proangiogenic properties of cardiac stromal cells expressing stem cell antigen (Sca)‐1 were demonstrated in myocardial infarction models. Interstitial adenosine, known to be increased in ischemic tissues, has been suggested to promote angiogenesis. In this study, we tested the hypothesis that stimulation of adenosine receptors on cardiac stromal cells promotes secretion of proangiogenic factors. Using magnetic sorting, we isolated mouse cardiac Sca‐1 + CD31 − stromal cells. We determined that they predominantly express mRNA encoding the A 2B adenosine receptor subtype and low levels of A 2A adenosine receptor transcripts. Stimulation of adenosine receptors with 5′‐N‐ethylcarboxamidoadenosine (NECA) increased IL‐6, CXCL1 and vascular growth factor (VEGF) release by 2–4‐fold. Using conditionally immortalized Sca‐1 + CD31 − stromal cells obtained from wild‐type and A 2B receptor knockout mouse hearts, we demonstrated that the A 2B receptor subtype is essential for adenosine‐dependent upregulation of their paracrine functions. We found that the human heart also harbors a similar population of stromal cells that predominantly express A 2B receptors and respond to stimulation with by increased IL‐6, IL‐8 and VEGF release. Thus, our study identified A 2B adenosine receptors on cardiac stromal cells as potential targets for upregulation of proangiogenic factors in the ischemic heart. Support: R01HL095787
Revisiting silicate substituted hydroxyapatite by solid‐state NMR (2008)

Silicon-substituted hydroxyapatite (Si-HAp) has shown promising properties such as high-bone remodeling around implants. So far, the techniques used for the structural characterization of the Si-HAp have given indirect evidence of the presence of silicon inside the structure (by X-ray and neutron diffraction). In this paper, we focus on Si-HAp derivatives obtained by a precipitation method (widely described in the literature). We demonstrate here by solid-state NMR spectroscopy that only a fraction of the silicon atoms are incorporated into the HAp lattice in the form of Q(0) (SiO(4) (4-)) species, for 4.6 wt% Si-HAp. A large amount of silicate units are located outside the HAp structure and correspond to silica-gel units. All results were established through (29)Si MAS, (1)H -->(29)Si CP MAS and T(1)rho((1)H) edited (1)H -->(29)Si CP MAS experiments. This last pulse scheme acted as a powerful editing sequence, leading to unambiguous spectroscopic conclusions, concerning the location of the SiO(4) (4-) moieties.
Recent Research and Applications of (Ti_(1-x)Al_x)N Thin Hard Coating (2007)

As a kind of ternary nanocomposite thin hard coatings,TiAlN thin hard coatings showed super mechanical properties than TiN coatings,for instance,the hardness of TiAlN coatings can reach 47GPa,much higher than that of TiN coatings;and TiAlN coatings are thermally stable until 700℃,but TiN coatings are oxidation at 500℃.In addition,TiAlN coatings have other superiorities such as super wear resistance,lower friction,lower thermal expansion and lower thermal conductivity,which is influenced by the Al content of film,the temperature of substrate and the nitrogen flux.In this paper,the applications,preparation,crystal structure,antioxidation and hardness of the TiAlN coatings are introduced in brief.
Centroid Evolution Theorem Induced from Fractal Super Fibers or Fractal Super Snowflakes (2009)

Article Centroid Evolution Theorem Induced from Fractal Super Fibers or Fractal Super Snowflakes was published on June 1, 2009 in the journal International Journal of Nonlinear Sciences and Numerical Simulation (volume 10, issue 6).
Cancer : principles & practice of oncology : primer of the molecular biology of cancer/ editors, Vincent T. DeVita, Jr, Theodore S. Lawrence, Steven A. Rosenberg; with 82 contributing authors (2015)

Understand and apply the scientific advances that are revolutionizing cancer research and practice with Cancer: Principles and Practice of Oncology: Primer of the Molecular Biology of Cancer. Derived from DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology - widely hailed as the definitive clinical reference in oncology - the second editon of this popular Primer focuses on the molecular biology information that is of critical importance to research scientists and clinical oncologists alike.* Get up-to-date, dependable coverage of every important frontier in aspect of the molecular biology of cancer with contributions from a noteworthy roster of leading scientists and clinicians, featuring an updated version of the classic Hallmarks of Cancer by Hanahan and Weinberg* See how molecular biology advances are impacting clinical practice with separate chapters on each of the 19 most common cancer types.* Navigate the challenges and ethical dilemmas of cancer genetics with a thorough section chapters on genetic counseling and genetic testing.Now with the print edition, enjoy the bundled interactive eBook edition, offering tablet, smartphone, or online access to:*Complete content with enhanced navigation* A powerful search that pulls results from content in the book, your notes, and even the web*Cross-linked pages, references, and more for easy navigation*Highlighting tool for easier reference of key content throughout the text* Ability to take and share notes with friends and colleagues*Quick reference tabbing to save your favorite content for future use
Ac losses in two-layer superconducting power transmission cables consisting of coated conductors with a magnetic substrate (2009)

Electromagnetic field analyses were made in cross-sections of two-layer superconducting power transmission cables consisting of coated conductors to calculate their ac losses, neglecting the spiral arrangement of the coated conductor and assuming each coated conductor was parallel to the cable axis. A substrate of each coated conductor was placed inside when assembling the coated conductors into a cable. Based on the electromagnetic field analyses, ac losses in the superconductor layer in the coated conductor as well as those in the magnetic substrate were calculated. The magnetism of the substrate increases ac losses in the outer-layer coated conductors and in the inner-layer coated conductors in different ways. In outer-layer coated conductors, the hysteretic loss in the magnetic substrate itself dominates their ac losses, because their magnetic substrates are directly exposed to the magnetic field produced by the inner-layer current. In inner-layer coated conductors, ac loss in the superconductor layer increases, because the magnetic substrate of the outer-layer coated conductor attracts magnetic flux to increase the magnetic field component normal to the superconductor layer of the inner-layer coated conductor. The influence of the space between the two layers as well as the width of the coated conductor on the ac loss characteristics is also discussed.
Spatial resolution of time-reversal arrays in shallow water (2001)

A series of time-reversal experiments was performed in shallow water including a range-dependent slope environment. Time-reversal arrays implemented with center frequencies of 445 and 3500 Hz achieved sharp focal regions up to ranges of 30 and 13 km, respectively in 110–130-m shallow water. In this paper, resolution expressions are derived using an image method to describe the focal sizes achieved with time-reversal arrays in various ocean environments. Analysis for the measured data indicates that the focal size approaches the diffraction limit of an array for given waveguide conditions, i.e., waveguide geometry and attenuation. The measured focal size has implications for the maximum achievable resolution of linear matched-field processing which is a computational implementation of the time-reversal process.
ChemInform Abstract: Di(arylethynyl)bis(trimethylphosphine)platinum(II): A New Series of Liquid‐Crystalline Materials. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lack of importance of the superior laryngeal nerves in citric acid cough in humans (1993)

The relative importance of laryngeal afferents in the cough reflex in humans is unknown. This study was designed to investigate the importance of superior laryngeal nerve afferents in the cough reflex induced by inhaled nebulized citric acid in awake humans. Nine healthy volunteers had their cough thresholds to inhaled nebulized citric acid measured after superior laryngeal nerve conduction blockade and after a sham nerve block. Of the nine subjects, four showed no change in cough threshold after superior laryngeal nerve anesthesia, three showed increased cough threshold after nerve block compared with no block, and two showed decreased cough threshold after nerve block. The geometric means of the cough thresholds for the nerve block vs. sham block tests were 16 +/- 13 (SD) and 15 +/- 8% citric acid, respectively. There was no statistically significant difference (Wilcoxon signed-rank test) between the cough thresholds with and without superior laryngeal nerve block (P > 0.05). We conclude that, in the awake human, superior laryngeal nerve afferents do not play a necessary role in initiation of citric acid-induced cough.
Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics (2022)

Maytansinoids are a successful class of natural and semisynthetic tubulin binders, known for their potent cytotoxic activity. Their wider application as cytotoxins and chemical probes to study tubulin dynamics has been held back by the complexity of natural product chemistry. Here we report the synthesis of long-chain derivatives and maytansinoid conjugates. We confirmed that bulky substituents do not impact their high activity or the scaffold's binding mode. These encouraging results open new avenues for the design of new maytansine-based probes.
"IMS in a Bottle": Initial Experiences from an OpenSER-based Prototype Implementation of the 3GPP IP Multimedia Subsystem (2006)

The 3 GPP IP multimedia subsystem (IMS) is currently expected to provide the basic architecture framework for the next generation network which will bridge the traditional divide between circuit-switched and packet-switched networks and consolidate both sides into one single network for all services. Therefore, the imminent commercial roll-out of IMS will have immense impact on the whole way future mobile business applications are designed, developed and deployed. This paper presents a survey about the application-oriented research project CAMPARI (configuration, architecture, migration, performance analysis and requirements of 3G IMS) which aims at inves-tigating a "minimal-optimal" IMS configuration with respect to architecture and quality-of-service aspects. After a brief survey of the IMS core components, we introduce our OpenSER-based IMS prototype implementation and present the "IMS in a bottle " approach. Based on our practical experiences with this testbed system, we finally discuss important current and future challenges including migration, interworking, charging, identity management, security, and regulatory aspects.
Pt–Au Triangular Nanoprisms with Strong Dipole Plasmon Resonance for Hydrogen Generation Studied by Single-Particle Spectroscopy (2016)

Three anisotropic Pt-covered, Pt-edged, and Pt-tipped Au triangular nanoprisms (TNPs) were prepared by controlling the overgrowth of Pt as photocatalysts for H2 generation. With strong electric field and more interface for the hot electrons transfer, the H2 generation rate of Pt-edged Au TNPs was 3 and 5 times higher than those of Pt-tipped and Pt-covered Au TNPs. Single-particle photoluminescence (PL) spectra and finite-difference-time-domain (FDTD) simulations demonstrated that dipole surface plasmon resonance (DSPR) of Au TNPs enhanced the hot electrons transfer from Au to Pt leading to H2 generation. SPR bands of Au TNPs depending on the size play an important role on the photocatalytic activity of Pt-edged Au TNPs.
Detection of bacterial growth by gas absorption (1992)

When 24 different aerobic organisms were grown in a shaken culture, all were found to first absorb gas from the headspace. In a rudimentary medium, such as tryptic soy broth, 16 of the 24 organisms did not produce gas following the initial gas absorption. We have developed a simple, noninvasive method for detecting both gas absorption and production in multiple culture vials. The time to positivity was compared with that obtained by the BACTEC 460 blood culture system. For nearly all of these organisms, there was no difference. For some of those organisms that did not produce gas, e.g. Staphylococcus epidermidis, Moraxella osloensis, and Neisseria meningitidis, detection by gas absorption was a few hours faster. Gas absorption appears to be a promising technique for a new automated blood culture system because of its simplicity and because medium without special additives can be used to detect organisms that do not produce gas.
Data from Signatures Associated with Rejection or Recurrence in HER-2/<i>neu</i>–Positive Mammary Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;We have previously shown T-cell–mediated rejection of the neu-overexpressing mammary carcinoma cells (MMC) in wild-type FVB mice. However, following rejection of primary tumors, a fraction of animals experienced a recurrence of a neu antigen-negative variant (ANV) of MMC (tumor evasion model) after a long latency period. In the present study, we determined that T cells derived from wild-type FVB mice can specifically recognize MMC by secreting IFN-γ and can induce apoptosis of MMC &lt;i&gt;in vitro&lt;/i&gt;. Neu transgenic (FVBN202) mice develop spontaneous tumors and cannot reject it (tumor tolerance model). To dissect the mechanisms associated with rejection or tolerance of MMC tumors, we compared transcriptional patterns within the tumor microenvironment of MMC undergoing rejection with those that resisted it either because of tumor evasion/antigen loss recurrence (ANV tumors) or because of intrinsic tolerance mechanisms displayed by the transgenic mice. Gene profiling confirmed that immune rejection is primarily mediated through activation of IFN-stimulated genes and T-cell effector mechanisms. The tumor evasion model showed combined activation of Th1 and Th2 with a deviation toward Th2 and humoral immune responses that failed to achieve rejection likely because of lack of target antigen. Interestingly, the tumor tolerance model instead displayed immune suppression pathways through activation of regulatory mechanisms that included in particular the overexpression of interleukin-10 (IL-10), IL-10 receptor, and suppressor of cytokine signaling (SOCS)-1 and SOCS-3. These data provide a road map for the identification of novel biomarkers of immune responsiveness in clinical trials. [Cancer Res 2008;68(7):2436–46]&lt;/p&gt;&lt;/div&gt;
Sonochemical Synthesis and Characterization of Nanometer-Size Transition Metal Oxides from Metal Acetates (2000)

Transition metal oxide nanoparticles have been synthesized sonochemically from metal acetates. The metal oxide nanoparticles are characterized using X-ray diffraction (XRD), diffuse reflection spectroscopy (DRS), transmission electron microscopy (TEM), and BET nitrogen adsorption. The results of DRS are analyzed in detail, and the band gap energies for CuO, ZnO, and Co3O4 are seen to be 2.18, 3.35, and 2.26 (3.40), respectively. Different particle sizes, morphology, and yields are observed when water and 10% water−N,N-dimethylformamide (DMF) are used as solvents, and the possible mechanisms are discussed.
Indoor Navigation Using Augmented Reality (2020)

Navigation System are very much essential for en-route assistance, indoor positioning etc. For outdoor environment navigation is still better as compared to complex indoor environment. In this research work, we have focused on building an indoor navigation application which uses augmented reality to assist people in navigating at complex buildings and also making a cloud platform (Content Management System) from where the administrator of a particular building can be able to modify and manage the navigation path. We have used Unity 3d framework to develop the AR based mobile application. The application can be run on smartphones. It has been seen that this augmented reality-based application provides better interface and experience than the traditional 2D maps or the paper maps that are displayed outside buildings to help in the navigation. To evaluate the concept proposed in the research, technical evaluations were performed at a hospital building.
Sb-heterostructure diode detector W-band NEP and NEDT optimization (2006)

Sb-heterostructure diodes have become the detector of choice for W-band millimeter wave imaging cameras now being commercialized or in prototype development. Here we optimize the diode impedance to yield a minimum noise equivalent power (NEP). The goal is to decrease the gain required of the front-end LNA. Measured W-band sensitivities for two diodes are 3500 and 5500V/W. Their zero bias differential resistance values imply Johnson noise limited NEP's of 0.98 and 0.83pW/Hz<sup>1/2</sup>, respectively, much less than obtained from conventional biased Schottky diodes. A MMIC version of the diode detector has been simulated with an integrated bandwidth of ~ 30 GHz at W-band. The simulated temperature sensitivity (NE&#916;T) with an HRL W-band LNA on the front end is <1°K.
Development of a Quartz-Based Photo-Mobile Polymer Film for Controlled Motion Triggered by Light or Heat (2023)

We have developed a photo-mobile polymer film, that combines organic and inorganic materials, to allow for controlled motion that can be triggered by light or heat. Our film is made using recycled quartz and consists of two layers: a multi-acrylate polymer layer and a layer containing oxidized 4-amino-phenol and N-Vinyl-1-Pyrrolidinone. The use of quartz in our film also gives it a high temperature resistance of at least 350 °C. When exposed to heat, the film moves in a direction that is independent of the heat source, due to its asymmetrical design. Once the heat source is removed, the film returns to its original position. ATR-FTIR measurements confirm this asymmetrical configuration. This technology may have potential applications in energy harvesting, due to the piezoelectric properties of quartz.
Validation of a maternal questionnaire on correlates of physical activity in preschool children (2009)

Overall, this maternal questionnaire had reasonable validity and internal consistency for assessing potential correlates of physical activity in young children. With minor revision, this could be a useful tool for future research in this area. This, in turn, will aid the development of interventions to promote physical activity in this age group.
Activation of the SARS-CoV-2 NSP14 3′–5′ exoribonuclease by NSP10 and response to antiviral inhibitors (2021)

Understanding the core replication complex of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential to the development of novel coronavirus-specific antiviral therapeutics. Among the proteins required for faithful replication of the SARS-CoV-2 genome are nonstructural protein 14 (NSP14), a bifunctional enzyme with an N-terminal 3'-to-5' exoribonuclease (ExoN) and a C-terminal N7-methyltransferase, and its accessory protein, NSP10. The difficulty in producing pure and high quantities of the NSP10/14 complex has hampered the biochemical and structural study of these important proteins. We developed a straightforward protocol for the expression and purification of both NSP10 and NSP14 from Escherichia coli and for the in vitro assembly and purification of a stoichiometric NSP10/14 complex with high yields. Using these methods, we observe that NSP10 provides a 260-fold increase in k<sub>cat</sub>/K<sub>m</sub> in the exoribonucleolytic activity of NSP14 and enhances protein stability. We also probed the effect of two small molecules on NSP10/14 activity, remdesivir monophosphate and the methyltransferase inhibitor S-adenosylhomocysteine. Our analysis highlights two important factors for drug development: first, unlike other exonucleases, the monophosphate nucleoside analog intermediate of remdesivir does not inhibit NSP14 activity; and second, S-adenosylhomocysteine modestly activates NSP14 exonuclease activity. In total, our analysis provides insights for future structure-function studies of SARS-CoV-2 replication fidelity for the treatment of coronavirus disease 2019.
Analysis and simulation of queueing models for reservation-based bandwidth access with large propagation delays (2003)

Motivated by reservation-based multiple access protocols in satellite networks, we consider discrete time queueing models in which the allocation of a server to the queue/s is based on delayed queue length information. Service allocations are made at frame boundaries, and in general a frame consists of several slots, each of which can carry one packet. We analyse a model in which the service allocation at each frame boundary is based on the most recently observed queue length. In this model the queue length process is a Markov chain of order /spl Delta/+1, where /spl Delta/ is the round trip delay in frame times. An interesting aspect of this model is that bandwidth allocations go to waste, since the queue to which bandwidth is allocated may not have that many packets. For the case of a single node, independent and identically distributed arrivals, and when each frame has one slot, we are able to obtain explicit expressions for the generating function of the stationary queue length. A decomposition formula similar that found in vacation models is shown to hold. We use simulations to study the case of multiple slots per frame, and the case of two nodes. We also examine a model in which the bandwidth scheduler bases its allocations on the most recently observed queue length, and on the past allocations already made. We show how the mean queue length, the coefficient of variation of queue length, and the average wasted reservations vary with arrival rate, and the round trip delay /spl Delta/.
Genomic profiling of HIV-1 integration in microglia links viral insertions to TAD organization (2022)

ABSTRACT HIV-1 persists in anatomically distinct cellular and tissue reservoirs as a stably integrated provirus that is a major barrier to HIV-1 cure. Proviral insertions are largely characterized in blood cells, while HIV-1 integration patterns remain unexplored in microglia, the major brain reservoir. Here, we employ genomics approaches to obtain the first HIV-1 integration site (IS) profiling in microglia and perform in-depth analysis of transcriptome, specific histone signatures and chromatin accessibility on different genomic scales. We show that HIV-1 follows genic insertion patterns into introns of actively transcribed genes, characteristic of blood reservoirs. HIV-1 insertional hotspot analysis by non-negative matrix factorization (NMF)-based approach clusters IS signatures with genic- and super-enhancers. Chromatin accessibility transcription factor (TF) footprints reveal that increased CTCF binding marks latently infected microglia compared to productively infected one. We identify CTCF-enriched topologically associated domain (TAD) borders with signatures of active chromatin as a neighborhood for HIV-1 integration in microglia and CD4 + T cells. Our findings further strengthen the notion that HIV-1 follows the patterns of host cell genome organization to integrate and to establish the silent proviral state and reveal that these principles are largely conserved in different anatomical latent reservoirs.