gebhart/patrepeval huggingface dataset:
Accelerated Wound Healing by In vivo Application of Keratinocytes Overexpressing KGF (2004)

Epidermal regeneration is a complex process, strongly influenced by growth factors, including keratinocyte growth factor (KGF). The objective of this study was to establish immortalized HaCaT keratinocytes and KMST-6-fibroblasts stably expressing KGF. Transfection efficiency, genomic integration, and functionality of the transgene were determined by ELISA and PCR, and KGF-expressing clones were selected using an air-liquid interface test system. HaCaT cells displayed stronger transgene expression compared to transfected fibroblasts, and the most effective HaCaT clone was incubated on a membrane carrier to form a "membrane cell graft." Twenty-one superficial second-degree burn wounds were created in each of three pigs, and wound healing capacity of the generated "polypeptide cell delivery system" after grafting was examined. Untransfected HaCaT keratinocytes and membrane-covered and untreated burn wounds served as controls. Histological and macroscopical follow-up revealed that grafting of transfected HaCaT cells resulted in complete reepithelialization within 5 days, while wounds covered with untransfected cells needed 2 days longer. At untreated sites, a thin epithelium was detectable after 10 days. The results indicate that wound healing processes can be stimulated distinctly by growth factors secreted from HaCaT cells, with a prominent role for transgenic KGF.
Sonochemical synthesis of nanocrystallites of ruthenium sulfide, RuS1.7 (2000)

Nanocrystalline ruthenium sulfide has been synthesised sonochemically using ruthenium chloride and thiourea as precursors. Sonication of an aqueous solution of ruthenium chloride and thiourea yields an X-ray amorphous product which on heating at 650 °C yields nanocrystalline ruthenium sulfide of stoichiometry RuS1.7 with a characteristic XRD pattern. The products have been characterized by powder XRD, TEM, DSC, TGA, CHN analysis, XPS and DRS.
Women and Leadership: Theatre (2014)

"We have something of the utmost importance to contribute: the sensibility, the experience and the expertise of one half of humanity. All we ask is that we are able to do this in conditions of complete equality." (Dorothy Hewitt, launching the Australia Council's 'Women in the Arts' report, 1983) Published in 2005, Rachel Fensham and Denise Varney's important book, The Doll's Revolution: Australian Theatre and Cultural Imagination, argues that the 1990s was a period in which women entered the theatrical mainstream and radically changed not just theatre but the way in which we think about Australian culture and identity: "Women playwrights, directors and actors have entered the mainstream. Their work has contributed to, if not radically transformed, the production of local and export quality Australian theatre and culture. At their most innovative, these women artists have revolutionised the stage of the last fifteen years with celebrated and award winning productions." (Fensham and Varney, 329) This surely is the very definition of creative leadership: to have not only the creative wherewithal but the ability and influence to affect not just theatre but ideas around nationhood and identity. It suggests that women have come a long way indeed since the 1970s, when they had to fight to be heard in even the most alternative and apparently radical of forums. Notably, however, Fensham and Varney also draw attention in closing to several key areas of concern, the first of which is the decline 'in the proportion of women writers in the repertoire of the mainstream companies in the mid-2000s' (337).
MicroRNA detection using magnetic separation and zinc-based nanolabels as signal transducers (2012)

In this work, a new microplate based assay for the detection of microRNA (miRNA) is described. The assay uses suspensions of paramagnetic beads immobilized with locked nucleic acid (LNA) oligonucleotide probes to capture miRNA. Poly(A) tails are generated on the captured miRNA using the poly(A) polymerase reaction. Poly(T)30 oligonucleotides hybridize with poly(A) tails and are subsequently labeled with ZnS nanoparticles through biotin–NeutrAvidin chemistry. For signal transduction, zinc ions from the ZnS nanoparticles are released to bind with and activate zinc-ion depleted carbonic anhydrase. The activated kinetics of carbonic anhydrase converts fluorescein diacetate to fluorescein for fluorescence measurement. This work presents a method combining polyadenylation, ion release of nanolabels, and enzyme activation for miRNA detection in a convenient, magnetic bead-based microplate assay format.
Acoustic Analysis of Breathy and Rough Voice Characterizing Elderly Speech (2010)

This paper aims at investigating acoustic features, which can objectively explain breathiness and roughness of elderly speech, respectively. In this paper, acoustic analysis was carried out using word sequences, which were uttered by 153 male speakers in the age range of between 20 and 89 years old. Concerning the breathiness, we confirmed that elderly breathy voices caused energy lift in higher frequency region over 4 kHz in average power spectra during the stationary parts in the uttered vowels. Concerning roughness, we observed the slight fluctuations, which synchronized with vocal cord vibration, in amplitude spectra during stationary parts of vowels. Based on acoustic analysis results, we propose physical parameters for measuring breathiness and roughness, respectively. In this paper, listening tests were carried out to quantitatively give the subject degrees of breathiness and roughness, respectively. It was confirmed that the proposed physical parameters had correlation with each of subjective degrees. Relationships between age and acoustic characteristics of breathiness and roughness were investigated using the proposed parameters. It is confirmed that the degree of breathiness and roughness increased in proportion to age, especially in age ranges over 60 years old.
Preoperative chronic kidney disease predicts poor oncological outcomes after radical nephroureterectomy in patients with upper urinary tract urothelial carcinoma (2017)

Upper tract urothelial carcinoma patients with preoperative CKD had a significantly lower survival probability than those without CKD.
Analysis of Infectious Complications Occurring After Solid-Organ Transplantation (1992)

To improve our understanding of posttransplant infections, we analyzed bacterial, viral, fungal, parasitic, and other infections in 604 consecutive recipients of kidney (n = 518), kidney-pancreas (n = 82), kidney-liver (n = 3), or kidney-islet (n = 1) allografts (355 cadaveric, 14 living-unrelated, 235 living-related donors) who also received cyclosporine, azathioprine, and prednisone immunosuppression. Recipients of cadaveric grafts received additional induction immunosuppression (antilymphocyte globulin or murine monoclonal antibody OKT3). Rejection episodes were treated with high-dose steroids, and either antilymphocyte globulin or OKT3 was administered when clinically indicated. Perioperative antibiotics and posttransplant prophylactic acyclovir sodium or ganciclovir sodium, trimethoprim-sulfamethoxazole, and clotrimazole or nystatin (Mycostatin) were administered to all recipients. Two hundred thirteen patients (35.3%) were found to have had no identifiable infections, while 391 (64.7%) had either isolated bacterial (97 [16.1%]), viral (53 [8.8%]), or fungal (34 [5.6%]) infections or combination (concurrent or sequential) infections with bacterial plus viral (46 [7.6%]), bacterial plus fungal (66 [10.9%]), viral plus fungal (20 [3.3%]), bacterial plus viral plus fungal (64 [10.6%]), or bacterial plus viral plus fungal plus parasitic (11 [1.8%]) pathogens in the posttransplantation period. Renal allograft survival (percentage, actuarial method) was diminished in patients with infections at both 1 year (91% vs 83%) and 3 years (81% vs 76%) after transplantation, as was actuarial patient survival (1 year, 97% vs 92%; 3 years, 93% vs 88%). We conclude that infection remains a major cause of both patient demise and allograft loss following successful solid-organ transplantation.
The Inhibitory Effect of New Hydroxamic Acid Derivatives on Melanogenesis (2008)

The aim of present study was to examine the inhibitory effects of hydroxamic acid derivatives on the melanogenesis. We found that hydroxamic acid moiety was important for anti-melanogenic activity. Compounds 1a and 1b strongly inhibited melanin synthesis via deactivation of tyrosinase. Hydroxamic acid has metal ion chelating ability which is similar to that kojic acid, however, anti-tyrosinase mechanism of compounds 1a and 1b was different from that of kojic acid. They showed noncompetitive inhibition kinetics
Costs and Radiographic Outcomes of Rotational Ankle Fractures Treated by Orthopaedic Surgeons With or Without Trauma Fellowship Training (2018)

Introduction We evaluated the radiographic outcomes and surgical costs of surgically treated rotational ankle fractures in our health system between providers who had completed a trauma fellowship and those who had not. Methods We grouped patients into those treated by trauma-trained orthopaedic surgeons (TTOS) and non-trauma-trained orthopaedic surgeons (NTTOS). We graded the quality of fracture reductions and calculated implant-related costs of treatment. Results A total of 208 fractures met the inclusion criteria, with 119 in the TTOS group and 89 in the NTTOS group. Five patients lost reduction during the follow-up period. The adequacy of fracture reduction at final follow-up did not differ (P = 0.29). The median surgical cost was $2,940 for the NTTOS group and $1,233 for the TTOS group (P Discussion We found no notable differences in radiographic outcomes between the TTOS and NTTOS groups. Cost analysis demonstrated markedly higher implant-related costs for the NTTOS group, with the median surgical cost being more than twice that for the TTOS group. Level of evidence Level III.
COMPARISON OF FLOW FIELD BETWEEN STEADY AND UNSTEADY FLOW OF AN AUTOMOTIVE MIXED FLOW TURBOCHARGER TURBINE (2016)

Global decarbonizing efforts in transportation industry have forced the automotive manufacturers to opt for highly downsized high power-to-weight ratio engines. Since its invention, turbocharger remains as integral element in order to achieve this target. However, although it has been proven that a turbocharger turbine works in highly pulsatile environment, it is still designed under steady state assumption. This is due to the lack of understanding on the nature of pulsating flow field within the turbocharger turbine stage. This paper presents an effort to visualize the pulsating flow feature using experimentally validated Computational Fluid Dynamics (CFD) simulations. For this purpose, a lean-vaned mixed-flow turbine with rotational speed of 30000 rpm at 20 Hz flow frequency, which represent turbine operation for 3-cylinder 4-stroke engine operating at 800 rpm has been used. Results indicated that the introduction of pulsating flow has resulted in more irregular pattern of flow field as compared to steady flow operation. It has also been indicated that the flow behaves very differently between pressure increment and decrement instances. During the pressure decrement instance, flow blockage in terms of low pressure region occupies most of the turbine passage as the flow exit the turbine.
Interplay between HIV Entry and Transportin-SR2 Dependency (2011)

Here we discover a link between the viral entry of HIV and its interaction with TRN-SR2. Our data confirm the importance of TRN-SR2 in HIV-1 replication and argue for careful interpretation of experiments performed with VSV-G pseudotyped viruses in studies on early steps of HIV replication including the role of capsid therein.
Bottom-up Photonic Crystal Cavities Formed by Patterned III–V Nanopillars (2011)

We report on the formation and optical properties of bottom-up photonic crystal (PC) cavities formed by III-V nanopillars (NPs) via catalyst-free selective-area metal-organic chemical vapor deposition on masked GaAs substrates. This method of NP synthesis allows for precise lithographic control of NP position and diameter enabling simultaneous formation of both the photonic band gap (PBG) region and active gain region. The PBG and cavity resonance are determined by independently tuning the NP radius r, pitch a, and height h in the respective masked areas. Near-infrared emission at 970 nm is achieved from axial GaAs/InGaAs heterostructures with in situ passivation by laterally grown InGaP shells. To achieve out-of-plane optical confinement, the PC cavities are embedded in polydimethylsiloxane (PDMS) and removed from the growth substrate. Spatially and spectrally resolved 77 K photoluminescence demonstrates a strong influence of the PBG resonance on device emission. Resonant peaks are observed in the emission spectra of PC cavities embedded in PDMS.
J-B-T-ε interaction and strain limits in A15, B1, and C15 crystal structure superconductors (1983)

Experimental evidence is presented which indicates, that the elastic strain effect on the critical current of high-field compound superconductors correlates strongly with the type of superconductor crystal structure. Large strain effects are observed in all practical A15 superconductors examined to date, including Nb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Sn, Nb-Hf/Sn-Ga, Nb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Ge, Nb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Al, and V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Ga. Strain is observed to have no measurable effect, however, on either the critical current or the critical field of superconductors having the B1 crystal structure [NbN] or the C15 crystal structure [V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> (Hf, Zr)]. Strain limits placed on the mechanical design of superconducting devices are evaluated as a function of magnetic field for several A15 superconductors (Nb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Sn, Nb-Hf/Cu-Sn-Ga, and V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> Ga) and compared with the strain limits imposed by B1 and C15 superconductors. It is shown that the latter materials have mechanical design advantage in applications where the superconductor is subjected to strain in excess of 0.2% (either compressive or tensile).
The effect of substituents on the polymerisation of lactams (1964)

Abstract Substituents influence the polymerisation of lactams by their effects on the ring closure reaction in the equilibrium between cyclic monomer and polymer. The effects of substituents on the enthalpy of ring closure of caprolactam is discussed in terms of the change in gauche interactions and the configuration of the amide bond. The entropy of ring closure is also considered qualitatively. This simple theoretical approach gives reasonable agreement with the experimental results.
[Treatment of skeletal Class II malocclusion by orthodontic and surgical means]. (2000)

Skeletal class II malocclusion is often occurred in Oriental and Black. It is difficult to gain the ideal treatment objective either using the orthognathic surgery or orthodontic treatment alone. However, the combined orthodontic and surgical treatment can reach it, so we investigate the methods and characteristics of combined orthodontic and surgical treatment in skeletal class II malocclusion.We analyzed the recent 22 cases with skeletal class II malocclusion in Hospital of Stomatology, West China University of Medical Sciences with 7 male and 15 female from 20 to 30 years old. In the study, we discussed the time of extraction, the peculiarity of orthodontic treatment and the selection of surgery type.After the combined orthodontic and surgical treatment, all the patients regained satisfactory face appearance and function. The selection of surgery type is decided by the skeletal characteristics of malocclusion (the malformation degree and the position). The upper first premolars were extracted before the orthodontic treatment for the purpose of better curing of surface of the skeletal wound. And the pre and post-surgical orthodontic treatment were very important and necessary to regain the ideal face appearance and function.The combined orthodontic and surgical treatment is an efficient way to cure skeletal class II malocclusion. Suitable orthognathic surgery and rational orthodontic treatment are important to treat adult skeletal class II malocclusion.
Die Synthese von Dihydro‐Sphingosin (1952)

Abstract The resolution of synthetic racemic dihydro‐sphingosine is described. The physical properties of the laevo‐rotatory 2‐amino‐1,3‐dihydroxy‐octadecane ([α] D 27 = −14,1° in chloroform; m. p. 109°) are in agreement with those of natural dihydro‐sphingosine isolated by Seydel .
Identifying Injector-Producer Relationships in Waterflood Using Hybrid Constrained Nonlinear Optimization (2010)

Abstract A key barrier to optimal field management, i.e., maximizing oil production and reducing operational cost, is the understanding of underlying structure of the field, which continuously changes over time. Analyzing readily available injection and production data to identify injector-producer relationships (IPRs) offers a convenient way to this understanding. The capacitance-resistive model (CRM) provides an intuitive and straightforward way to characterize IPRs through production and injection rate fluctuations. However, it requires a large number of model parameters. The number of parameters increases quadratically with number of production and injection wells in the reservoir. For fields consisting of hundreds of wells identifying IPRs among the wells is challenging. Moreover, there is no analytical solution for solving the parameter values due to the nonlinear time constant parameters of the CRM and the constraints. This paper presents a new method, a hybrid constrained nonlinear optimization (HCNO), for estimating the optimal parameter values of a nonlinear predictive model. HCNO is optimization-based algorithm such that it estimates the optimal values of the model parameters satisfying the constraints. HCNO separates the connectivity and time constant parameters of CRM then uses two different optimization algorithms. A constrained nonlinear optimization algorithm is applied to estimating the time constant parameters, and subsequently the connectivity parameters are estimated by a constrained linear optimization algorithm with the estimated time constant parameters. The coupled optimization is performed at each iteration, which leads to faster convergence. HCNO is tested on several synthetic oil fields. The result showed that the search time and the prediction error by HCNO were significantly less than those of estimating the parameters as a whole by solely constrained nonlinear optimization. The identification of IPRs by the optimal parameter estimation will help field engineers’ decision making process in optimizing waterflooding.
A Comparison of Perioperative Costs and Outcomes in Patients With and Without Workers’ Compensation Claims Treated With Minimally Invasive or Open Transforaminal Lumbar Interbody Fusion (2012)

Contrary to popular belief, immediate outcomes and hospitalizations between non-WC and WC populations did not differ regardless of surgical technique (MIS/open). Differences occurred in improved outcomes with an MIS TLIF versus an open TLIF even in a WC environment. MIS TLIF WC and non-WC patient hospital costs were lower than their open TLIF counterparts.
Ion-induced surface relaxation: controlled bending and alignment of nanowire arrays (2012)

It is a well-known fact that a sphere offers less surface area, and thus less surface energy, than any other arrangement of the same volume. From this perspective, all other shapes are metastable objects. In this paper, we present and discuss a manifestation of this metastability: the spontaneous alignment of free-standing amorphous nanowires towards, and ultimately parallel to, a flux of directional ion irradiation. The behavior expected from surface energy reduction is the opposite of that predicted by both theory and experiment regarding defect generation in crystalline nanowires, but is consistent with other observations on non-crystalline materials. We verify our expectations by bending and aligning finely stranded amorphous silica nanowires, noting that such nanostructures are particularly susceptible to bending through ion-induced surface energy reduction. We offer support for this mechanism through bending rate studies, thermal annealing experiments and mathematical modeling. Experimentally, we also demonstrate selective reorientation of nanowires in patterned areas, as well as conformal coating of reoriented arrays with functional materials. These capabilities offer the prospect of exploiting engineered surface anisotropies in optical, fluidic and micromechanical applications.
Chronic Kidney Disease after Nonrenal Solid-Organ Transplantation (2007)

Chronic kidney disease (CKD) is a common complication after nonrenal solid-organ transplantation. The risk for CKD is influenced by many factors, some of which have a direct impact on how such patients are treated in the pre-, peri-, and posttransplantation settings. This review describes hazards for acute and chronic kidney injury, with particular emphasis on calcineurin inhibitor-mediated nephrotoxicity. Rather than a detailed description of management issues that are common to the general CKD population, highlighted are aspects that are more specific to nonrenal solid-organ transplant recipients with a focus on liver, heart, and lung recipients. Strategies to minimize nephrotoxic insults and retard progressive renal injury are discussed, as are issues that are pertinent to dialysis and transplantation. Finally, future approaches to prevent and treat CKD without compromising function of the transplanted organ are addressed.
Regularization of inverse photomask synthesis to enhance manufacturability (2009)

Mask manufacturability has been considered as a major issue in the adoption of inverse lithography (IL) in practice. With smaller technology nodes, IL distorts the mask pattern more aggressively. The distorted mask often contains curvilinear contour and irregular shapes, which cast a heavy computation burden on segmentation and data preparation. Total variation (TV) has been used for regularization in previous work, but it is not very effective in regulating the mask shape to be rectangular. In this paper, we apply TV regularization not only on the mask image but also on the mask edges, which forces the curves of edges to be more vertical or horizontal, because they give smaller TV values. Except for rectilinearity, a group of geometrical specifications of the mask pattern set by mask manufacture rule control (MRC) is also important for mask manufacturability. To prevent these characteristics from appearing, we also propose an intervention scheme into the optimization framework. © 2009 Copyright SPIE - The International Society for Optical Engineering.
Competition between cleavage of alkyl– or aryl–transition metal bonds by electrophiles (1977)

Reactions of methyl(4-tolyl)metal derivatives with various electrophilic reagents give preferential cleavage of the methyl–metal bond in cis-[PtMe(4-MeC6H4)(PMe2Ph)2] but the 4-tolyl–metal bond in [PtMe(4-MeC6H4)(cyclo-octa-1,5-diene)] and in cis-[AuMe2(4-MeC6H4)(PPh3)].