gebhart/patrepeval huggingface dataset:
The year 2020 in the European Heart Journal – Cardiovascular Imaging: part I (2021)

The European Heart Journal - Cardiovascular Imaging was launched in 2012 and has during these 9 years become one of the leading multimodality cardiovascular imaging journals. The journal is currently ranked as number 20 among all cardiovascular journals. Our journal is well established as one of the top cardiovascular journals and is the most important cardiovascular imaging journal in Europe. The most important studies published in our Journal in 2020 will be highlighted in two reports. Part I of the review will focus on studies about myocardial function and risk prediction, myocardial ischaemia, and emerging techniques in cardiovascular imaging, while Part II will focus on valvular heart disease, heart failure, cardiomyopathies, and congenital heart disease.
Early outcome after laparoscopic sleeve gastrectomy of type two diabetes mellitus patients with extremely elevated glycated hemoglobin (HbA1c) (2013)

According to our study we have not found correlation between high HbA1c levels and increased peri-operative morbidity or insufficient excess weight loss among patients who underwent laparoscopic sleeve gastrectomy.
Intramolecular hydroalkoxylation catalyzed inside a self-assembled cavity of an enzyme-like host structure (2014)

Self-assembled resorcin[4]arene hexamer catalyzes the intramolecular hydroalkoxylation of unsaturated alcohols to the corresponding cyclic ethers under mild conditions. The mode of catalysis and encapsulation-based substrate selectivity of the host efficiently mimic the basic principle of operation observed in enzymes.
Initial Experience With rhBMP‐2 Delivered in a Compressive Resistant Matrix for Mandibular Reconstruction in 5 Dogs (2014)

The efficacy and success of this mandibular reconstruction technique, using rhBMP-2/CRM with plate fixation, was demonstrated with bridging of large mandibular defects regardless of the underlying cause, and with excellent cosmetic and functional results. Complications were common, but considered minor and easily treated. The complications encountered revealed the importance of tailoring the use of BMPs and fixation methods to this specific anatomic location and indication.
Q-switched and mode-locked QW diode lasers with implanted multisectional saturable absorber (2002)

A process of implantation of high energy heavy ions into the emitter layer of a semiconductor laser has been developed to create distributed ultrafast saturable absorber regions integrated within the cavity of a QW laser. A picosecond Q-switched laser diode delivering increased average power has been fabricated and multiple colliding pulse modelocked regime has been demonstrated with QW diode lasers having an implanted multisectional saturable absorber.
Intra-aortic Balloon Counterpulsation Augments Cerebral Blood Flow in the Patient with Cerebral Vasospasm: A Xenon-enhanced Computed Tomography Study (1998)

This is the first report demonstrating the ability of IABC to improve CBF in a patient with vasospasm. We suggest that IABC is a rational treatment option in select patients with refractory cerebral vasospasm who do not respond to traditional treatment measures.
Independently addressable subarrays of silicon microdischarge devices: Electrical characteristics of large (30×30) arrays and excitation of a phosphor (2001)

Large arrays (up to 30×30) of microdischarge devices having separately addressable subarrays have been fabricated in Si and operated continuously in Ne, Ne/Ar, and Ne/Xe gas mixtures at pressures up to 800 Torr. Eight 3×3 arrays fabricated on the same substrate operate simultaneously at voltages as low as 210 V in 400 Torr of Ne and exhibit lifetimes beyond 19 h, or approximately 1 order of magnitude larger than those for earlier arrays in which all devices have a common anode. Four 15×15 arrays have also been tested and, when operated in Ne/Ar or Ne/10% Xe gas mixtures, generate intense fluorescence in the green from a phosphor over an area of 16 mm2.
Review Article Cancer-linked targets modulated by curcumin (2012)

In spite of major advances in oncology, the World Health Organization predicts that cancer incidence will double within the next two decades. Although it is well understood that cancer is a hyperproliferative disorder medi- ated through dysregulation of multiple cell signaling pathways, most cancer drug development remains focused on modulation of specific targets, mostly one at a time, with agents referred to as therapies, smart drugs, or magic bullets. How many cancer targets there are is not known, and how many targets must be attacked to con- trol cancer growth is not well understood. Although more than 90% of cancer-linked deaths are due to metastasis of the tumor to vital organs, most drug targeting is focused on killing the primary tumor. Besides lacking specificity, the targeted drugs induce toxicity and side effects that sometimes are greater problems than the disease itself. Furthermore, the cost of some of these drugs is so high that most people cannot afford them. The present report describes the potential anticancer properties of curcumin, a component of the Indian spice turmeric (Curcuma longa), known for its safety and low cost. Curcumin can selectively modulate multiple cell signaling pathways linked to inflammation and to survival, growth, invasion, angiogenesis, and metastasis of cancer cells. More clinical trials of curcumin are needed to prove its usefulness in the cancer setting.
Liposomal Formulations for Inhalation (2013)

No marketed inhaled products currently use sustained release formulations such as liposomes to enhance drug disposition in the lung, but that may soon change. This review focuses on the interaction between liposomal formulations and the inhalation technology used to deliver them as aerosols. There have been a number of dated reviews evaluating nebulization of liposomes. While the information they shared is still accurate, this paper incorporates data from more recent publications to review the factors that affect aerosol performance. Recent reviews have comprehensively covered the development of dry powder liposomes for aerosolization and only the key aspects of those technologies will be summarized. There are now at least two inhaled liposomal products in late-stage clinical development: ARIKACE(®) (Insmed, NJ, USA), a liposomal amikacin, and Pulmaquin™ (Aradigm Corp., CA, USA), a liposomal ciprofloxacin, both of which treat a variety of patient populations with lung infections. This review also highlights the safety of inhaled liposomes and summarizes the clinical experience with liposomal formulations for pulmonary application.
Open circuit voltage of stacked bulk heterojunction organic solar cells (2006)

We investigate the open circuit voltage (VOC) of stacked bulk heterojunction (BHJ) organic solar cells based on conjugated polymer and fullerene derivative by spin-coating method. Poly[2-methoxy-5-(3′,7′-dimethyloctyloxy)-1,4-phenylene vinylene] (MDMO-PPV) blended with [6, 6]-phenyl C61-butyric acid methyl ester (PCBM) is used as a photoactive layer. The structure is ITO(lower BHJ cell)PEDOT:PSS/MDMO-PPV:PCBM/ITO/(upper BHJ cell)PEDOT:PSS/MDMO-PPV:PCBM/Al. VOC of the stacked cell is 1.34V and is about 1.6 times as large as that of single BHJ organic solar cell. VOC of the stacked cell is not proportional to the number of photoactive layers, but is the sum of the VOC values of the upper and the lower BHJ cells.
PMD tolerance of polarization division multiplex transmission using return-to-zero coding (2001)

Polarization division multiplex (PolDM) doubles the data rate in existing trunk lines without need for additional optical bandwidth. In the presence of dispersion compensation, polarization mode dispersion (PMD) limits the achievable transmission length. PMD tolerance of standard binary intensity modulation or non-return-to-zero coding has already been published. Recently, the return-to-zero (RZ) transmission format has become of more interest; therefore we assess the PMD tolerance of PolDM by numerical simulations and a transmission experiment. For a given total data rate per wavelength PolDM supports at least as much differential group delay as standard binary intensity modulation. So, PolDM is an attractive multilevel modulation scheme to solve capacity problems with low additional effort.
Autoimmune Disease and Collagen Dermal Implants (1994)

Letters15 March 1994Autoimmune Disease and Collagen Dermal ImplantsRichard A. Beauchamp, MD, Jean Cukier, MD, and David E. Trentham, MDRichard A. Beauchamp, MDTexas Department of Health; Austin, TX 78756Search for more papers by this author, Jean Cukier, MDTexas Department of Health; Austin, TX 78756Search for more papers by this author, and David E. Trentham, MDTexas Department of Health; Austin, TX 78756Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-6-199403150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We vigorously disagree with Drs. Singh and Fries. Our study does not fully establish causality but is not biologically implausible. Bovine collagen injections produce delayed-type hypersensitivity reactions in 3% of patients and humoral immune responses in another 10% [1]. Immunization with type II collagen of bovine, human, chick, or rat origin induces autoimmune arthritis in rats [2], mice [3], and monkeys [4]. Other inducible autoimmune diseases include experimental allergic encephalomyelitis, thyroiditis, orchitis, and uveitis [5]. With only 322 patients participating in the 1985-86 survey by Lyon and colleagues, the probability of finding a patient with dermatomyositis or polymyositis ...References1. McCoy JP Jr, Schade WJ, Siegle RJ, Waldinger TP, Vanderveen EE, Swanson NA. Characterization of the humoral immune response to bovine collagen implants. Arch Dermatol. 1985; 121:990-4. Google Scholar2. Trentham DE, Townes AS, Kang AH. Autoimmunity to type II collagen: an experimental model of arthritis. J Exp Med. 1977; 146:857-68. Google Scholar3. Holmdahl R, Jansson L, Gullberg D, Rubin K, Forsberg PO, Klareskog L. Incidence of arthritis and autoreactivity of anti collagen antibodies after immunization of DBA/1 mice with heterologous and autologous collagen II. Clin Exp Immunol. 1985; 62:639-46. Google Scholar4. Cathcart ES, Hayes KC, Gonnerman WA, Lazzari AA, Franzblau C. Experimental arthritis in a nonhuman primate. I. Induction by bovine type II collagen. Lab Invest. 1986; 54:26-31. Google Scholar5. Samter M, Talmage DW, Frank MM, Austen KF, Claman HN, ed. Immunological Diseases. 4th ed. vol II. Boston: Little, Brown and Company; 1988:1437-916. Google Scholar Author, Article, and Disclosure InformationAuthors: Richard A. Beauchamp, MD; Jean Cukier, MD; David E. Trentham, MDAffiliations: Texas Department of Health; Austin, TX 78756 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1994Volume 120, Issue 6 Page: 524-526 Keywords Adverse reactions Autoimmune diseases Dermatomyositis Food and Drug Administration Humoral immune response Polymyositis Scleroderma Skin tests Thyroid Uveitis ePublished: 15 August 2000 Issue Published: 15 March 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
An Introduction to Bacterial Physiology (1954)

effort, it is of real value to public health workers. The detailed classification of subject matter is such that the report serves as a ready reference for the public health worker who wishes to be kept informed of current problems and progress toward their solutions. The section on Digestion and Metabolism illustrates this point with its 15 subject headings, including such items as: amino acids and proteins, lipides, enzyme effects, hormone effects, antimetabolites and interrelations, growth factors, and tissue biochemistry. The section on Food Technology includes the following subheadings, chemical additives, engineering methods and equipment, developmental research (in all food groups), and processing and storage. ALICE H. SMITH
Die Cast Magnesium Alloys for High Temperature Applications (2003)

&lt;div class="htmlview paragraph"&gt;The development of creep resistant alloys for automotive drive train components has proven to be metallurgically challenging. This paper discusses the principles of high temperature alloy development, featuring metallurgical, microstructural and processing aspects of some alloys, relative to their high temperature performance. The creep resistant alloys within the Mg-Al base system obtain their creep resistance by a relatively low content of Al, and addition of elements that form stable intermetallic phases within the grain mantle. Various third elements affect the high temperature performance differently. The results demonstrate that rare earth elements (RE) show a remarkable potential as the third element(s).&lt;/div&gt;
Paclitaxel (Taxol) attenuates clinical disease in a spontaneously demyelinating transgenic mouse and induces remyelination (2002)

Treatment with paclitaxel by four intraperitoneal injections (20 mg/kg) 1 week apart attenuated clinical signs in a spontaneously demyelinating model, if given with onset of clinical signs. If given at 2 months of age (1 month prior to clinical signs), disease was almost completely prevented The astrogliosis, prominent in our model, was reversed by paditaxel as determined by astrocyte counts and quantitation of GFAP. Electron microscopic examination of affected regions at 2.5 months demonstrated that the myelin was generally normal. By 4 months of age, demyelination was common in the superior cerebellar peduncle, maximal at 6 months, but continued to 8 months. In addition to myelin vacuolation and nude axons, the presence of many thin myelin sheaths suggested remyelination or partial demyelination. Although no evidence of oligodendrocyte loss was seen, nuclear changes were observed. To substantiate that remyelination was occurring, we measured MBP (18.5 kDa), MBP-exon II, Golli-MBP, TP8, Golli-MBP-J37, platelet-derived growth factor alpha (PDGFR alpha) and sonic hedgehog (SHH). Of these TP8, PDGFR alpha and SHH were up-regulated in the untreated transgenic. After paditaxel treatment, MBP-Exon II, TP8, PDGFR alpha and SHH were further up-regulated. We concluded that some of the effects of paditaxel were to stimulate proteins involved in early myelinating events possibly via a signal transduction mechanism.
Input/Output Discrete Event Processes and System Modeling (1993)

In this paper we present an input/output interpretation of supervisory control theory. As opposed to the model proposed by Ramadge and Wonham, the plant does not spontanuously generate all events as outputs, but reads some events, called commands, as inputs and produces other events, called responses, as outputs. Based on this input/output interpretation we propose a modeling framework that starts with a physical description of the system and ends with the system model. This is performed by designing software routines interacting with the system at appropriate time instances.
Base‐catalyzed hydrolysis of 6‐aminopenicillanic acid. The kinetic and thermodynamic products (1977)

Abstract In the presence of sodium hydroxide or a β‐lactamase, 6‐APA has been shown to hydrolyze rapidly at room temperature to penicic acid 3 , the kinetic product of the reaction. In a subsequent equilibration 3 isomerizes at C‐5, by way of intermediate imine 4 , affording 5‐epi‐penicic acid 6 as the major hydrolysis product (∼ 95% at equilibrium). The pH and temperature parameters of equilibration are discussed and HPLC, optical rotation, proton nmr and 13 C nmr data are presented.
Complex Stiffness Gradient Substrates for Studying Mechanotactic Cell Migration (Adv. Mater. 45/2012) (2012)

Complex stiffness gradient substrates for the study of mechanotactic cell migration are developed by Easan Sivaniah, Kristian Franze, and co-workers on page 6059. Polyacrylamide gels are cast upon a stiff support with controlled topography, resulting in a thin gel layer of variable height. The topographical profiles project a stiffness map onto the gel, resulting in controlled linear and non-linear 2D stiffness gradients. Fibroblasts, which migrate towards stiffer substrates, accumulate in areas with a gel thickness below 15 μm.
Insect herbivores selectively suppress the HPL branch of the oxylipin pathway in host plants (2012)

Insect herbivores have developed a myriad of strategies to manipulate the defense responses of their host plants. Here we provide evidence that chewing insects differentially alter the oxylipin profiles produced by the two main and competing branches of the plant defensive response pathway, the allene oxide synthase (AOS) and hydroperoxide lyase (HPL) branches, which are responsible for wound-inducible production of jasmonates (JAs), and green leafy volatiles (GLVs) respectively. Specifically, we used three Arabidopsis genotypes that were damaged by mechanical wounding or by insects of various feeding guilds (piercing aphids, generalist chewing caterpillars and specialist chewing caterpillars). We established that emission of GLVs is stimulated by wounding incurred mechanically or by aphids, but release of these volatiles is constitutively impaired by both generalist and specialist chewing insects. Simultaneously, however, these chewing herbivores stimulated JA production, demonstrating targeted insect suppression of the HPL branch of the oxylipin pathway. Use of lines engineered to express HPL constitutively, in conjunction with quantitative RT-PCR-based expression analyses, established a combination of transcriptional and post-transcriptional reprogramming of the HPL pathway genes as the mechanistic basis of insect-mediated suppression of the corresponding metabolites. Feeding studies suggested a potential evolutionary advantage of suppressing GLV production, as caterpillars preferably consumed leaf tissue from plants that had not been primed by these volatile cues.
Simultaneous Transmit and Receive (STAR): Circulators Versus Nonreciprocal Antennas (2019)

Desired antenna and front-end for simultaneous transmit and receive systems in addition to nonlinear and/or time variant nonreciprocal antennas are reviewed. The STAR system requirements in terms of antennas and front-end are investigated. Then, the properties of some proposed techniques for nonreciprocal antennas and circulator-based systems are investigated.
Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2 (2005)

To elucidate the specific biological role of the yeast homologues of PTPA (phosphatase 2A phosphatase activator), Ypa1 and Ypa2 (where Ypa stands for yeast phosphatase activator), in the regulation of PP2A (protein phosphatase 2A), we investigated the physical interaction of both Ypa proteins with the catalytic subunit of the different yeast PP2A-like phosphatases. Ypa1 interacts specifically with Pph3, Sit4 and Ppg1, whereas Ypa2 binds to Pph21 and Pph22. The Ypa1 and Ypa2 proteins do not compete with Tap42 (PP2A associating protein) for binding to PP2A family members. The interaction of the Ypa proteins with the catalytic subunit of PP2A-like phosphatases is direct and independent of other regulatory subunits, implicating a specific function for the different PP2A-Ypa complexes. Strikingly, the interaction of Ypa2 with yeast PP2A is promoted by the presence of Ypa1, suggesting a positive role of Ypa1 in the regulation of PP2A association with other interacting proteins. As in the mammalian system, all yeast PP2A-like enzymes associate as an inactive complex with Yme (yeast methyl esterase). Ypa1 as well as Ypa2 can reactivate all these inactive complexes, except Pph22-Yme. Ypa1 is the most potent activator of PP2A activity, suggesting that there is no direct correlation between activation potential and binding capacity.
Trustera: A Live Conversation Redaction System (2023)

Trustera, the first functional system that redacts personally identifiable information (PII) in real-time spoken conversations to remove agents' need to hear sensitive information while preserving the naturalness of live customer-agent conversations. As opposed to post-call redaction, audio masking starts as soon as the customer begins speaking to a PII entity. This significantly reduces the risk of PII being intercepted or stored in insecure data storage. Trustera's architecture consists of a pipeline of automatic speech recognition, natural language understanding, and a live audio redactor module. The system's goal is three-fold: redact entities that are PII, mask the audio that goes to the agent, and at the same time capture the entity, so that the captured PII can be used for a payment transaction or caller identification. Trustera is currently being used by thousands of agents to secure customers' sensitive information.
Role of the fusion splice in the concatenation problem (1984)

Near-field measurements used to derive an empirical model of a fusion splice have indicated that fusion splices generate very little mode coupling between multimode graded-index fibers of identical parameters. Results of dispersion measurements confirm this. In particular it is found that the bandwidth of a concatenated link of identical fibers (respliced fibers from the same preform) is determined by longitudinal profile variations and not splice characteristics. Fusion splices between nonidentical fibers can generate a larger degree of mode coupling. This unequal parameter-induced mode coupling has a measurable effect on file dispersion properties of concatenated fiber links.
Research on extremely low frequency magnetic signal detection and fundamental frequency estimation algorithm (2017)

The spectrogram of signal is an effective method to analyze the extremely low frequency magnetic field signal. The proposed method is one of the detection algorithm based on the spectrogram. The existence of the target is judged by the harmonics frequency of the spectrum line in the spectrogram. The proposed methods improve the probability of detecting the target and the method can estimate the fundamental frequency of the extremely low frequency magnetic field signal. The simulation and real experiment confirm that the method is effective to analyze the extremely low frequency magnetic field signal.
Further characterization of marek's disease virus‐infected lymphocytes. II. In vitro infection (1984)

Abstract Lymphocyte cultures from chicken spleens had been shown to be susceptible to in vitro infection by Marek's disease virus (MDV) 4 in an earlier report from this laboratory. In that study, virus infection was evidenced by virus isolation and detection of viral internal antigen (VIA) 2 days post inoculation (DPI), and serial passage was accomplished by adding fresh spleen cells at 2‐day intervals. The susceptible cells were identified as bursa‐derived lymphocytes (B cells). Using a dual fluorescence technique to identify surface markers for B cells, thymus‐derived lymphocytes (T cells) or la antigen on VIA‐positive cells, we have now shown that a small proportion (generally less than 10%) of VIA‐positive cells observed 2 DPI are T cells, and that a low level of infection can be maintained by serial passage of MDV in cultures totally free of B cells. Most infected T cells in this study had Ia antigen. As the incubation period for infected cultures was extended from 2 to 4 or 5 days, the average number of viable cells decreased but the percentage of viable cells infected with MDV (VIA‐positive) increased. Also, both the proportion and the actual number of infected T cells increased, significantly more so in cultures from genetically susceptible P‐2 donors than from resistant N‐2 donors. Spleen‐cell cultures from resistant Line 6 chickens were markedly less susceptible than those from susceptible Line 7 chickens to in vitro MDV infection, as assessed by numbers of VIA‐positive cells at 5 DPI.