gebhart/patrepeval huggingface dataset:
A Cloud Computing Solution for Patient's Data Collection in Health Care Institutions (2010)

Existing processes for patients' vital data collection require a great deal of labor work to collect, input and analyze the information. These processes are usually slow and error-prone, introducing a latency that prevents real-time data accessibility. This scenario restrains the clinical diagnostics and monitoring capabilities. We propose a solution to automate this process by using ¿sensors¿ attached to existing medical equipments that are inter-connected to exchange service. The proposal is based on the concepts of utility computing and wireless sensor networks. The information becomes available in the ¿cloud¿ from where it can be processed by expert systems and/or distributed to medical staff. The proof-of-concept design applies commodity computing integrated to legacy medical devices, ensuring cost-effectiveness and simple integration.
Direct modulation of the protein kinase a catalytic subunit α by growth factor receptor tyrosine kinases (2011)

The cyclic-AMP-dependent protein kinase A (PKA) regulates processes such as cell proliferation and migration following activation of growth factor receptor tyrosine kinases (RTKs), yet the signaling mechanisms that link PKA with growth factor receptors remain largely undefined. Here we report that RTKs can directly modulate the function of the catalytic subunit of PKA (PKA-C) through post-translational modification. In vitro kinase assays revealed that both the epidermal growth factor and platelet derived growth factor receptors (EGFR and PDGFR, respectively) tyrosine phosphorylate PKA-C. Mass spectrometry identified tyrosine 330 (Y330) as a receptor-mediated phosphorylation site and mutation of Y330 to phenylalanine (Y330F) all but abolished the RTK-mediated phosphorylation of PKA-C in vitro. Y330 resides within a conserved region at the C-terminal tail of PKA-C that allosterically regulates enzymatic activity. Therefore, the effect of phosphorylation at Y330 on the activity of PKA-C was investigated. The K(m) for a peptide substrate was markedly decreased when PKA-C subunits were tyrosine phosphorylated by the receptors as compared to un-phosphorylated controls. Importantly, tyrosine-phosphorylated PKA-C subunits were detected in cells stimulated with EGF, PDGF, and Fibroblast growth factor 2 (FGF2) and in fibroblasts undergoing PDGF-mediated chemotaxis. These results demonstrate a direct, functional interaction between RTKs and PKA-C and identify tyrosine phosphorylation as a novel mechanism for regulating PKA activity.
Abstract MP10: A Novel Genetic Locus Influences Microvascular Reactivity To Acute Psychological Stress (2021)

Background: Excessive peripheral microvascular constriction during acute psychological stress, measured using peripheral arterial tonometry reflects similar changes in coronary blood flow.The ratio of digital pulse wave amplitude during stress compared to rest (sPAT) is used to estimate the degree of microvascular response to stress. Hypothesis: We hypothesized that genetic factors contribute to the degree of microvascular constriction during mental stress and that excessive vasoconstriction is associated with adverse cardiovascular outcomes. Methods: A total of 580 stable CAD subjects of European and African ancestries from two prospective cohort studies underwent mental stress testing with a standardized public speaking stressor. Digital pulse wave amplitude was continuously measured using PAT and the stress/rest PAT ratio (sPAT) of pulse wave amplitude during mental stress/baseline was calculated. Genotyping was performed using Illumina’s Multi-Ethnic Genotyping Array platform and imputed to the 1000 Genome reference panel. Ethnicity-specific genome-wide association studies (GWAS) of sPAT were conducted using linear regression of additive genetic mode adjusted for age, sex and population stratification in both cohorts. A trans-ethnic meta-analysis integrated the GWAS results from four sub-cohorts. Upon 5-year follow-up, Fine and Gray’s sub-distribution hazard ratios (sHR) were used to examine the association between sPAT ratio (&gt; vs=&lt; median) and the composite endpoint of cardiovascular death, myocardial infarction, revascularization, and hospitalization for heart failure. Results: Mean age was 63±9; 65% male, 35% African American. We identified three SNPs in linkage disequilibrium on chr7:111,666,943 T&gt;C (rs6466396); chr7: 111,668,622 T&gt;G (rs876170); chr7: 111,668,623 T&gt;G (rs876169) that were associated with greater sPAT ratio by means of 0.13, 0.12 and 0.10, ( P = 1.42E-08). The sPAT-associated locus was within DOCK4 gene which encodes Dedicator of Cytokinesis 4, an essential protein for angiogenesis and brain development, and a known locus for obesity. After adjusting for demographic and cardiovascular risk factors, medications, and rate-pressure product change during mental stress, those with low sPAT ratio were at significantly higher risk of adverse outcomes (sHR 1.8 [95% CI 1.1 - 2.8]). Conclusion: We have identified a genetic basis for stress-induced vasomotion. Presence of allele C (rs6466396) is associated with increased vasoconstriction during mental stress, and thus may predispose CAD patients to a higher risk for adverse cardiovascular outcomes with stressful exposure.
Prenatal Screening for Aneuploidy (2009)

A 37-year-old woman, gravida 1, seeks prenatal care at 8 weeks' gestation. Her family history and medical history are unremarkable. What would you advise regarding her risk of fetal chromosomal abnormalities such as Down's syndrome and her options for prenatal screening and diagnosis?
Deterioration of slot stress control materials on generator stator conductors by non-mechanical mechanisms (2002)

Long-term aging experiments conducted to examine mechanisms which could degrade a stator conductor slot stress control system are described. Models consisting of two conductor bars in a short length of core, single conductor bars, and other arrangements were used to investigate the development of slot discharge and compare the performances of various materials. Damage was found to start in the junction region between the slot stress control and endwinding stress control layer. Removal of the low-conductivity paint at the junction region led to surface discharge, which caused the consequent further erosion of the paint and led to complete removal of the slot stress control layer. The cause of the initial removal of paint is thought to be the action of ozone on the binding resin used in the paint. The ozone arose from discharge on bars in the test vessel or on an endwinding stress control layer. An improved version of the paint was shown to perform well, but the best results have been obtained with a low-conductivity molded tape layer. Such damage did not appear to develop in a hydrogen atmosphere.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Steroids and related natural products. 63. 17.beta.-Acetoxy-4-oxa-2-androstene (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteroids and related natural products. 63. 17.beta.-Acetoxy-4-oxa-2-androsteneGeorge R. Pettit and Tirumalai R. KasturiCite this: J. Med. Chem. 1970, 13, 6, 1244–1245Publication Date (Print):November 1, 1970Publication History Published online1 May 2002Published inissue 1 November 1970https://pubs.acs.org/doi/10.1021/jm00300a060https://doi.org/10.1021/jm00300a060research-articleACS PublicationsRequest reuse permissionsArticle Views33Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Grape seed oil extraction: Interest of supercritical fluid extraction and gas-assisted mechanical extraction for enhancing polyphenol co-extraction in oil (2014)

The aim of this study is to compare three oil extraction methods and to evaluate their efficiency for producing an oil rich in polyphenols. The three extraction methods are screw pressing, extraction by supercritical CO 2 percolation and the combination of these two processes (Gas-Assisted Mechanical Expression: GAME). Screw pressing is the most efficient process for producing grape seed oil with a high yield, but supercritical CO 2 process permits an increase of polyphenol co-extraction with oil. The GAME process allows extraction of more polyphenols than screw pressing and constitutes an interesting process considering oil yield.
Constraint Removal for MPC with Performance Preservation and a Hyperthermia Cancer Treatment Case Study (2021)

Model predictive control (MPC) is an optimization-based control strategy with broad industrial adoption. Unfortunately, the required computation time to solve the receding-horizon MPC optimization problem can become prohibitively large for many applications with a large number of state constraints. This large number of state constraints can, for instance, originate from spatially discretizing a partial differential equation of which the solution has to satisfy constraints over the full spatial domain. This is particularly the case in MPC for RF-based hyperthermia cancer treatments, which forms a strong motivation for this study. To address this problem, we propose a novel constraint-adaptive MPC framework for linear discrete-time systems. In this framework, we select at each time-step a subset of the state constraints that are included in the optimization problem, thereby reducing the online computational burden. Critically, our framework guarantees the same closed-loop performance, recursive feasibility, and constraint satisfaction properties as the original (non-reduced) MPC scheme. We achieve this result by efficiently exploiting reachable set computations and the MPC cost function. We will demonstrate our novel method using a hyperthermia cancer treatment case study showing a two-orders of magnitude improvement in computation time, with identical closed-loop performance as the original (non-reduced) MPC scheme.
Mortality Patterns in a Commercial Wean-To Finish Swine Production System (2019)

Modern commercial pig production is a complex process that requires successful producers to understand and resolve factors associated with perturbations in production. One important perturbation is inventory loss due to mortality. In this study, data on 60 lots of approximately 2000 weaned pigs (n = 115,213) from one commercial production system were collected through the wean-to-finish (WTF) cycle with the objective of establishing patterns of mortality, estimating differences in profit/loss among patterns of mortality, and identifying production practices associated with mortality patterns. Information provided by the production system included the number of pigs in each lot at the time of placement (beginning inventory), weaning weight, barn dimensions, number of dead pigs (NDP) daily, capacity placed (proportion pigs actually placed versus what had been planned to be placed) and average weight sold. Analysis of NDP revealed three mortality patterns (clusters I, II, III) composed of 6, 40, and 14 lots, respectively, that differed in the temporal onset and/or level of mortality. Average daily gain (ADG) and feed conversion ratio (FCR) were calculated by growth phase for each cluster. An economic model showed profit differences among clusters due to poor biological performance by clusters I and III in the late finishing phase. Cluster II (n = 40) had fewer dead pigs and the highest profit compared to clusters I (n = 6) and III (n = 14). Area per pig (stocking density) was the only factor associated with the differences in mortality patterns. Routine monitoring and the analysis of mortality patterns for associations with production and management factors can help swine producers improve biological performance and improve profit.
Perceptual photometric seamlessness in projection-based tiled displays (2005)

Arguably, the most vexing problem remaining for multi-projector displays is that of photometric (brightness) seamlessness within and across different projectors. Researchers have strived for &lt;i&gt;strict photometric uniformity&lt;/i&gt; that achieves identical response at every pixel of the display. However, this goal typically results in displays with severely compressed dynamic range and poor image quality. In this article, we show that strict photometric uniformity is not a requirement for achieving photometric seamlessness. We introduce a general goal for photometric seamlessness by defining it as an optimization problem, balancing &lt;i&gt;perceptual uniformity&lt;/i&gt; with &lt;i&gt;display quality&lt;/i&gt;. Based on this goal, we present a new method to achieve &lt;i&gt;perceptually seamless high quality displays&lt;/i&gt;. We first derive a model that describes the photometric response of projection-based displays. Then we estimate the model parameters and modify them using perception-driven criteria. Finally, we use the graphics hardware to reproject the image computed using the modified model parameters by manipulating only the projector inputs at interactive rates. Our method has been successfully demonstrated on three different practical display systems at Argonne National Laboratory, made of 2 × 2 array of four projectors, 2 × 3 array of six, projectors, and 3 × 5 array of fifteen projectors. Our approach is efficient, automatic and scalable---requiring only a digital camera and a photometer. To the best of our knowledge, this is the first approach and system that addresses the photometric variation problem from a perceptual stand point and generates truly seamless displays with high dynamic range.
Direct Chemisorption Site Selectivity for Molecular Halogens on the Si(111)-(7×7)Surface (1996)

Direct chemisorption site preferences within the Si(111)- $(7\ifmmode\times\else\texttimes\fi{}7)$ unit cell are examined for ${\mathrm{F}}_{2}$, C${\mathrm{l}}_{2}$, and B${\mathrm{r}}_{2}$. Abstractive chemisorption, which produces a single chemisorbed halide atom, always prefers center adatom adsorption, indicating that the site with the lowest electron density is the more reactive. Dissociative chemisorption, which produces a pair of chemisorbed halide atoms, shows an extreme preference for the closest neighboring pair of center adatoms. The notion of a stepwise direct chemisorption mechanism is upheld by these results.
High power broadband LiF:F_2 ^- color center laser (2015)

A high power LiF:F(2)(-) color center laser is demonstrated with broadband emission. The excitation source is a quasi-continuous wave diode side-pumped acousto-optically Q-switched Nd:YAG laser. Under an incident 1064-nm laser power of 25.4 W, the highest output power of up to 4.7 W is obtained with a macro pulse repetition rate of 400 Hz and a micro pulse repetition rate of 50 kHz. The broadband emission is centered at 1142 nm with a bandwidth of 13 nm.
Actor-citic agorithms (1999)

We propose and analyze a class of actor-critic algorithms for simulation-based optimization of a Markov decision process over a parameterized family of randomized stationary policies. These are two-time-scale algorithms in which the critic uses TD learning with a linear approximation architecture and the actor is updated in an approximate gradient direction based on information provided by the critic. We show that the features for the critic should span a subspace prescribed by the choice of parameterization of the actor. We conclude by discussing convergence properties and some open problems.
Disruption of Mechanisms That Prevent Rereplication Triggers a DNA Damage Response (2005)

Eukaryotes replicate DNA once and only once per cell cycle due to multiple, partially overlapping mechanisms efficiently preventing reinitiation. The consequences of reinitiation are unknown. Here we show that the induction of rereplication by mutations in components of the prereplicative complex (origin recognition complex [ORC], Cdc6, and minichromosome maintenance proteins) causes a cell cycle arrest with activated Rad53, a large-budded morphology, and an undivided nucleus. Combining a mutation disrupting the Clb5-Orc6 interaction (ORC6-rxl) and a mutation stabilizing Cdc6 (CDC6(Delta)NT) causes a cell cycle delay with a similar phenotype, although this background is only partially compromised for rereplication control and does not exhibit overreplication detectable by fluorescence-activated cell sorting. We conducted a systematic screen that identified genetic requirements for the viability of these cells. ORC6-rxl CDC6(Delta)NT cells depend heavily on genes required for the DNA damage response and for double-strand-break repair by homologous recombination. Our results implicate an Mre11-Mec1-dependent pathway in limiting the extent of rereplication.
Ammonia Volatilization from Urea and Mitigation by NBPT following Surface Application to Cold Soils (2011)

Urea is frequently surface applied to winter wheat (Triticum aestivum L.) during cold weather months (October–April) in the semiarid northern Great Plains. This study was conducted to quantify NH3 volatilization loss from surface-applied urea (100 kg N ha−1) and urea amended with N-(n-butyl) thiophosphoric triamide (NBPT) during this period. Ammonia emissions were quantified by a micrometeorological integrated horizontal flux method with samplers placed on a mast in the center of circular plots (20-m radius). Cumulative NH3 losses from urea varied but averaged 20.5% of applied N across 12 trials. The largest losses (30–44% of applied N) occurred after urea was applied to high-water-content soil surfaces, followed by a period of slow drying with little or no precipitation. Emissions occurred for a prolonged period often lasting >42 d. Periods (1–2 wk) of high NH3 flux (>30 g N ha−1 h−1) frequently occurred when mean daily soil temperatures (1-cm depth) were –2 to 5°C. In one trial, 24.3% of applied N was lost after urea was applied to a 140-mm snowpack. Ammonia losses were moderated by applying urea to dry soil surfaces. If precipitation events that followed were light (<8 mm), losses were reduced to 10 to 20% of applied N. If the events were heavy (>18 mm), then losses were <10%. Coating urea with NBPT (1 g kg−1) reduced cumulative NH3 losses by 66%. Volatilization protection lasted 2 to 3 wk on acidic soils, and >7 wk on an alkaline soil. This study demonstrated that significant NH3 losses from surface-applied urea could occur during cold weather months.
Low-noise impact-ionization-engineered avalanche photodiodes grown on InP substrates (2002)

We report low noise multiplication region structures designed for avalanche photodiodes grown on InP substrates. By either implementing a single heterostructure or using a pseudograded structure in the multiplication region, better control of spatial distribution of impact-ionization for both injected and feedback carriers can be achieved; localization of the carrier impact ionization process has resulted in very low excess noise.
Study on the Locking Function of Wedge-Shaped Thread (2018)

Traditional threaded connection locking effect is poor, this article obtains from the wedge thread, introduces the present wedge thread application at home and abroad, the principle of locking, and designs a set of wedge thread’ s pre-tightening torque reference value, verifies by experiment, and puts forward some suggestions for the application of wedge thread in engineering.
GRAFT SIZE ASSESSMENT AND ANALYSIS OF DONORS FOR LIVING DONOR LIVER TRANSPLANTATION USING RIGHT LOBE 1,2 (2001)

Right lobectomy from living donors is a safe procedure with acceptable morbidity, but some care should be taken early after the operation for donors with small residual liver and aged donors.
Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease (2016)

Levels of serum vitamin D correlate positively with colonic VDR expression in visually normal mucosa whereas inflammation correlates negatively with colonic VDR expression in visually diseased mucosa in Puerto Rican patients.
Highly efficient resonantly pumped Er:YAG large area waveguide laser with diffraction limited output (2013)

We demonstrated nearly a quantum defect limited CW operation of a 41-mm-long Er:YAG large area crystalline waveguide laser with a diffraction limited output, which was resonantly pumped by a fiber laser at 1532 nm. Using a Er(0.25%):YAG, 62 &mu;m x 62 &mu;m waveguide, surrounded by a 3 x 5 mm rectangular cladding of undoped YAG, an output power of 9.1 W with slope efficiency of 92.8% has been achieved. The output laser beam had a Gaussian profile with a ~ 2.8 x 10<sup>-2</sup> rad divergence, which is in good agreement with the divergence expected from a waveguide with a low NA value. The waveguide laser operated simultaneously at two wavelengths, 1617 nm and 1645 nm, when the transmission of the laser cavity output coupler was less than 20-25%, and operated only at 1617 nm when the laser output mirror had a higher transmission.
Optimum tuning of defense settings for common attacks on the web applications (2009)

Statistics from various sources indicate that there are roughly 75% cyber attacks occurred in the web applications, and the trend is growing. The unsafe coding of web application or the vulnerability of the application itself is yet to be patched result in a high security risk. In addition to white-box testing to examine the source code, black box testing for vulnerability scan or penetration test, one may choose to setup defense facilities at the front-end of the server - such as: application-layer intrusion prevention system, or application software and hardware firewall to enhance the defense mechanism or to gain more time to patch the vulnerability. This paper presents an optimum tuning method utilizing the application firewall widely used by the modern enterprises. We explore several attacking methods commonly used nowadays, such as the signature of cross-site scripting and SQL injection, and introduce a new method to setup the parameters of the device to strengthen the defense. To enhance the security of the back-end application servers, we use keyword filtering and re-treatment to rule out the blacklist, and to adjust the system settings so that it can effectively block the assaults or reduce the possibility of successful attacks. In addition, we also simulate attacks to web browsing and application through vulnerability scanning tools to test the security of application system and to make sure the necessary defense of the optimum tuning parameters. This concept does produce good results in our implementation of verification tests. It is worth promoting as a reference.
Atomic Layer Deposition of ZrO2 on Titanium Inhibits Bacterial Adhesion and Enhances Osteoblast Viability (2021)

Compared with the pure titanium group, the groups that were coated with zirconia via ALD showed a decreased adhesion of <i>S. mutans</i> during the early stages of biofilm formation and <i>P. gingivalis</i> adhesion inducing peri-implantitis, and an increase in MC3T3-E1 cell viability and differentiation. The findings indicate the possibility of treating the implant surface to reduce peri-implantitis and improve osseointegration.