gebhart/patrepeval huggingface dataset:
A Multiprocessor Extension to the Conventional File System Interface (1994)

As the I/O needs of parallel scientific applications increase, file systems for multiprocessors are being designed to provide applications with parallel access to multiple disks. Many parallel file systems present applications with a conventional Unix-like interface that allows the application to access multiple disks transparently. By tracing all the activity of a parallel file system in a production, scientific computing environment, we show that many applications exhibit highly regular, but non-consecutive I/O access patterns. Since the conventional interface does not provide an efficient method of describing these patterns, we present an extension which supports strided and nested-strided I/O requests. 1 Introduction While the computational power of multiprocessors has been steadily increasing for years, the power of the I/O subsystem has not been keeping pace. This is partly due to hardware limitations, but the shortcomings of the file systems bear a large part of the responsibil...
Polyoxometalate-based metal–organic framework-derived bimetallic hybrid materials for upgraded electrochemical reduction of nitrogen (2020)

The core–shell structure of the Fe<sub>1.89</sub>Mo<sub>4.11</sub>O<sub>7</sub>/FeS<sub>2</sub>@C hybrid material exhibits high-efficiency electrocatalytic NRR activity and stability under ambient conditions.
IMPROVING EFFECTS ON ULTIMATE STRENGTH AND DUCTILITY OF R/C COLUMNS WITH WING WALLS BY WRAPPING OF CFRP SHEETS AROUND COLUMN (2000)

Though the improving effects of reinforced concrete bare columns strengthened by CFRP (Carbon Fiber Reinforced Plastics) sheet jacketing have been clarified, the effective retrofitting method for the columns with wing walls could not be found. The first author showed experimentally that CFRP sheet wrapping method was effective for the enhancement of the deformability of such columns. However, the estimating method on such structural performance was not clarified. Then, the authors carried out the experiment to investigate the improving effects of the columns with wing walls using CFRP sheets and CF anchors which were jointed to CFRP sheets by passing through the wing walls beside the column. This paper shows the results of this experiment and the estimating method on the improving effects of this strengthening method.
Viral Vectors Encoding Endomorphins and Serine Histogranin Attenuate Neuropathic Pain Symptoms after Spinal Cord Injury in Rats (2015)

Findings from this study support the potential for direct gene therapy to provide a robust and sustained alleviation of chronic neuropathic pain following SCI. The combination strategy utilizing potent mu-opioid peptides with a naturally-derived NMDA antagonist may produce additive or synergistic analgesic effects without the tolerance development for long-term management of persistent pain.
Elf-Field Health Effects: Biological, or Illogical? (1992)

Share Icon Share Twitter Facebook Reddit LinkedIn Reprints and Permissions Cite Icon Cite Search Site Citation Franklin Hutchinson, Geoffrey A. Landis, Antony C. Fraser‐Smith, Franklin F. Offner, Robert K. Adair; Elf‐Field Health Effects: Biological, or Illogical?. Physics Today 1 September 1992; 45 (9): 13–100. https://doi.org/10.1063/1.2809792 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentPhysics Today Search Advanced Search
Photosensitive polymers. II. Sensitization of poly(vinyl cinnamate) (1959)

Abstract It was reported in Part I of this series that coatings of various polymers containing cinnamic ester groups are rendered insoluble by exposure to ultraviolet radiation, and that the rate of insolubilization may be increased by the inclusion of certain organic compounds. A continued systematic examination of the behavior of several hundred organic compounds has revealed that the ability to sensitize to some degree is quite general, provided that no complicating factors are present. The sensitivity of poly(vinyl cinnamate) is decreased by the presence of reducing groups in the addend, and sensitizing activity is lowered by interaction between adjacent groups. It is enhanced by the introduction of increasing conjugation and of ketone, nitro, or amino groups. Spectrograms of polymer‐sensitizer combinations indicate that, with increasing sensitivity value, the sensitivity shifts towards, and, in some cases, into, the visible portion of the spectrum.
Measurement of Residual Stress Distribution along the Depth Direction in Subsurface Layer by Polychromatic X-Rays. (1994)

The stress measurement method with characteristic X-ray has been already estabilished as one of the most effective nondestructive evaluation methods of residual stress. However, the classical sin2ψ method with characteristic X-ray cannot evaluate accurately residual stress in the subsurface of metallic material which is treated with cold rolling or grinding, because the three-dimensional stress distribution or a steep stress gradient occurs in its subsurface. Therefore, various characteristic X-ray methods to evaluate the stress distribution have been proposed. This paper presents a new measurement method with polychromatic X-rays for residual stress along the depth direction in a subsurface layer. In this method, the surface stress and stress gradient in a subsurface layer is evaluated by using the theoretical equation describing the relationship between diffracted beam peaks of polychromatic X-rays and a strain distribution along the depth direction. Then, the stress distribution of a JIS SKS51 steel plate ground on its surface was measured as an example of applying this method. In consequence, it is confirmed that the residual stress distribution along the depth direction in a subsurface layer can be determined by using this method.
Episomal plasmid-based generation of induced pluripotent stem cells from fetal femur-derived human mesenchymal stromal cells (2015)

Human bone mesenchymal stromal cells derived from fetal femur 55 days post-conception were reprogrammed to induced pluripotent stem cells using episomal plasmid-based expression of OCT4, SOX2, NANOG, LIN28, SV40LT, KLF4 and c-MYC and supplemented with the following pathway inhibitors - TGFβ receptor inhibitor (A-83-01), MEK inhibitor (PD325901), GSK3β inhibitor (CHIR99021) and ROCK inhibitor (HA-100). Successful induction of pluripotency in two iPS-cell lines was demonstrated in vitro and by the Pluritest.
Outage-Efficient Strategies for Multiuser MIMO Networks With Channel Distribution Information (2010)

In this paper, we examine single user and multiuser multiple-input multiple-output (MIMO) beamforming networks with channel distribution information (CDI). Since CDI changes infrequently compared to channel state information (CSI), algorithms based on CDI can achieve significant savings in feedback compared to algorithms based on CSI. With CDI, we can only guarantee quality of service for a specified outage probability in the network. Assuming correlated Rayleigh fading on all the links, we derive a closed-form expression for the outage probability. Then, using this expression, we derive algorithms for joint transmit/receive beamforming and power control to minimize the weighted sum power in the network while guaranteeing these outage probabilities. For both single-user and multiuser MIMO scenarios, we present optimal algorithms under the Kronecker model assumption, and we present near-optimal algorithms assuming general correlation structures on the links. We then show that using these algorithms based on CDI, if we are willing to accept given outages on the links, we can achieve comparable power usage in the network relative to algorithms based on CSI.
Nonisotopic Receptor Assay for Benzodiazepine Drugs Using Time-Resolved Fluorometry (1995)

A nonisotopic receptor assay for benzodiazepine drugs using a time-resolved fluorometric technique is described. A novel europium chelate-labeled benzodiazepine (Eu-1012-S) was prepared as a probe ligand for the binding assay based on the competitive inhibition of Eu-1012-S binding by benzodiazepine drugs to their receptors. In this system, the degree of the inhibition was proportional to the affinity of drugs for the receptor. Background fluorescence did not interfere with the measurement, due to the long-lifetime fluorescence of Eu-1012-S. The proposed nonisotopic assay may provide an alternative to radioreceptor assays of benzodiazepines in biological systems and could also be used to screen new benzodiazepine-like compounds from nature.
Revealing botnet membership using DNSBL counter-intelligence (2006)

... machines—are often used for nefarious activities (e.g., spam, click fraud, denial-of-service attacks, etc.). Identifying members of botnets could help stem these attacks, but passively detecting botnet membership (i.e., without disrupting the operation of the botnet) proves to be difficult. This paper studies the effectiveness of monitoring lookups to a DNS-based blackhole list (DNSBL) to expose botnet membership. We perform counter-intelligence based on the insight that botmasters themselves perform DNSBL lookups to determine whether their spamming bots are blacklisted. Using heuristics to identify which DNSBL lookups are perpetrated by a botmaster performing such reconnaissance, we are able to compile a list of likely bots. This paper studies the prevalence of DNSBL reconnaissance observed at a mirror of a well-known blacklist for a 45day period, identifies the means by which botmasters are performing reconnaissance, and suggests the possibility of using counter-intelligence to discover likely bots. We find that bots are performing reconnaissance on behalf of other bots. Based on this finding, we suggest counterintelligence techniques that may be useful for early bot detection.
Pulmonary availability of isotretinoin in rats after inhalation of a powder aerosol (2000)

Repeated oral administration of chemopreventive retinoids such as isotretinoin over extended periods of time is associated with intolerable systemic toxicity. Here isotretinoin was formulated as a powder aerosol, and its delivery to the lungs of rats was studied with the aim to explore the possibility of minimizing adverse effects associated with its oral administration. Rats received isotretinoin orally (0.5, 1 or 10 mg kg(-1)) or by inhalation (theoretical dose approximately 1 or approximately 10 mg kg(-1)) in a nose-only inhalation chamber. Isotretinoin was quantitated by high-pressure liquid chromatography in plasma and lung tissue. The ratios of mean area of concentration-vs-time curve (AUC) values in the lungs over mean AUCs in the plasma for isotretinoin following single or repeated aerosol exposure surpassed those determined for the oral route by factors of between two (single low-dose) and five (single high-dose). Similarly, the equivalent ratios for the maximal peak concentrations in lungs and plasma obtained after aerosol exposure consistently exceeded those seen after oral administration, suggesting that lungs were exposed to higher isotretinoin concentrations after aerosol inhalation than after oral administration of similar doses. Repeated high doses of isotretinoin by inhalation resulted in moderate loss of body weight, but microscopic investigation of ten tissues including lung and oesophagus did not detect any significant aerosol-induced damage. The results suggest that administration of isotretinoin via powder aerosol inhalation is probably superior to its application via the oral route in terms of achieving efficacious drug concentrations in the lungs.
The interaction of strigolactones with abscisic acid during the drought response in rice (2018)

Both strigolactones (SLs) and abscisic acid (ABA) biosynthetically originate from carotenoids. Considering their common origin, the interaction of these two hormones at the biosynthetic and/or regulatory level may be anticipated. Here we show that, in rice, drought simultaneously induces SL production in the root, and ABA production and the expression of SL biosynthetic genes in the shoot. Under control conditions, the ABA concentration was higher in shoots of the SL biosynthetic rice mutants dwarf10 (d10) and d17 than in wild-type plants, while a similar trend was observed for the SL perception mutant d3. These differences were enhanced under drought. However, drought did not result in an increase in leaf ABA content in the rice mutant line d27, carrying a mutation in the gene encoding the first committed enzyme in SL biosynthesis, to the same extent as in the other SL mutants and the wild type. Accordingly, d10, d17, and d3 lines were more drought tolerant than wild-type plants, whereas d27 displayed decreased tolerance. Finally, overexpression of OsD27 in rice resulted in increased levels of ABA when compared with wild-type plants. We conclude that the SL and ABA pathways are connected with each other through D27, which plays a crucial role in determining ABA and SL content in rice.
RNA-dependent inhibition of ribonucleotide reductase is a major pathway for 5-azacytidine activity in acute myeloid leukemia (2012)

5-Azacytidine (5-azaC) is an azanucleoside approved for myelodysplastic syndrome. Approximately 80%-90% of 5-azaC is believed to be incorporated into RNA, which disrupts nucleic acid and protein metabolism leading to apoptosis. A smaller fraction (10%-20%) of 5-azaC inhibits DNA methylation and synthesis through conversion to decitabine triphosphate and subsequent DNA incorporation. However, its precise mechanism of action remains unclear. Ribonucleotide reductase (RR) is a highly regulated enzyme comprising 2 subunits, RRM1 and RRM2, that provides the deoxyribonucleotides required for DNA synthesis/repair. In the present study, we found for the first time that 5-azaC is a potent inhibitor of RRM2 in leukemia cell lines, in a mouse model, and in BM mononuclear cells from acute myeloid leukemia (AML) patients. 5-azaC-induced RRM2 gene expression inhibition involves its direct RNA incorporation and an attenuated RRM2 mRNA stability. Therefore, 5-azaC causes a major perturbation of deoxyribonucleotide pools. We also demonstrate herein that the initial RR-mediated 5-azaC conversion to decitabine is terminated through its own inhibition. In conclusion, we identify RRM2 as a novel molecular target of 5-azaC in AML. Our findings provide a basis for its more widespread clinical use either alone or in combination.
The Public Historian and Business History: A Question of Ethics (1986)

Research Article| January 01 1986 The Public Historian and Business History: A Question of Ethics Carl Ryant Carl Ryant Search for other works by this author on: This Site PubMed Google Scholar The Public Historian (1986) 8 (1): 31–38. https://doi.org/10.2307/3377072 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Carl Ryant; The Public Historian and Business History: A Question of Ethics. The Public Historian 1 January 1986; 8 (1): 31–38. doi: https://doi.org/10.2307/3377072 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentThe Public Historian Search This content is only available via PDF. Copyright 1986 The Regents of the University of California Article PDF first page preview Close Modal You do not currently have access to this content.
RAPID INCREASE IN PLASMA AND URINARY CYCLIC GMP AFTER BOLUS INJECTION OF ATRIAL NATRIURETIC FACTOR IN MAN (1985)

We studied the effects of a bolus injection of 50/micrograms synthetic human atrial natriuretic factor (ANF) on the cyclic GMP and cyclic AMP levels in plasma and urine of eight normal men. Administration of the hormone increased basal immunoreactive (IR-) ANF levels in plasma 2.8-fold to 110 pM three minutes after injection. Thereafter, IR-ANF levels rapidly declined to basal levels. Plasma cyclic GMP levels increased 2.6-fold to 16.6 nM within 6 minutes after ANF and decreased to near basal values within 30 minutes. Urinary cyclic GMP excretion increased 2.8-fold, whereas urinary volume and sodium excretion increased less than two-fold in the 30 minutes after ANF. Plasma cyclic AMP levels did not change. The data indicate that changes in plasma IR-ANF levels are followed by changes in plasma cyclic GMP and in urinary cyclic GMP excretion and suggest that cyclic GMP is a biological marker for circulating ANF in man.
Practical Design Approach (2007)

This chapter contains sections titled: Element Effects and Selection Path Length and Phase Delay Calculation Radiation Pattern Calculation Reflectarray Geometry Design Reflectarray Power Handling References
How colorful! A feature it is, isn't it? (2015)

A display’s color subpixel geometry provides an intriguing opportunity for improving readability of text. True type fonts can be positioned at the precision of subpixel resolution. With such a constraint in mind, how does one need to design font characteristics? On the other hand, display manufactures try hard in addressing the color display’s dilemma: smaller pixel pitch and larger display diagonals strongly increase the total number of pixels. Consequently, cost of column and row drivers as well as power consumption increase. Perceptual color subpixel rendering using color component subsampling may save about 1/3 of color subpixels (and reduce power dissipation). This talk will try to elaborate the following questions, based on simulation of several different layouts of subpixel matrices: Up to what level are display device constraints compatible with software specific ideas of rendering text? How much of color contrast will remain? How to best consider preferred viewing distance for readability of text? How much does visual acuity vary at 20/20 vision? Can simplified models of human visual color perception be easily applied to text rendering on displays? How linear is human visual contrast perception around band limit of a display’s spatial resolution? How colorful does the rendered text appear on the screen? How much does viewing angle influence the performance of subpixel layouts and color subpixel rendering?
The influence of the peptide chain length on the activity of peptidyl-tRNA hydrolase from E. coli (1975)

The dependence of the Vmax and Km on the length of the peptide moiety in the peptidyl-tRNA series (Gly)n-Val tRNA, was measured in the system peptidyl-tRNA hydrolase-peptidyl-tRNA. It was found that the Km value decreases from 7.2 X 10-7 M for Gly-Val-tRNA to 4.6 X 10-7 M FOR (Gly)2-Val-tRNA and to 1.7 X 10-7M for (Gly)3-Val-tRNA; further increase of the peptide chain is not followed by decrease of the Km. The Vmax values are 5.7 pmole/min/EU for Gly-Val-tRNA and 42 pmole/min/EU for (Gly)3-Val-tRNA. The enzyme activity is inhibited competitively by uncharged tRNA with a KI value of about 10-5M. The significance of these results described in this paper, in relation to the fact that peptides and peptide esters do not inhibit the enzyme activity, and in relation to the proposed physiological role of the enzyme, is discussed.
MEASUREMNT OF TERMINAL VELOCITY AND DEFORMATION OF FALLING RAINDROPS USING AN ULTRA-HIGH-SPEED VIDEO CAMERA (2009)

超高速ビデオカメラを用いて自然状態で落下する雨滴を撮影し，粒径，落下速度，動的挙動などの計測を試み，それらの計測が可能であることを示した． 自然状態で落下する雨滴の超高速動画像（2万枚／秒）の撮影に成功し，落下雨滴の撮影画像から，雨滴の落下速度と粒径の関係を得ることができた．さらに撮影画像にデジタル画像処理を加えることにより，雨滴の形状の変化や回転などを短い時間間隔で求めることが可能であることを示した．またデータ数は少ないものの，画像より得られた落下雨滴粒径と速度の関係は，相当直径1.5mmまではGunnとKinzerの実験より求められたそれと良く一致すること，および雨滴の形状は横長であることが確認された．
Retarded emergence in Trypetidae (1938)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Softwarized and Autonomous Raman Amplifiers in Multi-Band Open Optical Networks (2020)

Starting from the software-defined-network (SDN) concept, this work aims to describe a softwarized system that is able to autonomously design and control Raman amplification in a specific fiber span link. The conceived software module produces the optimum Raman pump power configuration, satisfying amplification constraints given by the control plane through the Raman design unit (RDU). Raman pump power levels are changed using the Raman control Unit (RCU); the initial configuration is generated by the RDU and subsequently used by the RCU to track the mean target gain, according to feedback-provided telemetry data, in order to exploit a linearization of the problem around the optimum solution. This proposal is then validated through an experimental campaign to emulate the in-field operation of the system.
Magnetic-Field Enhancement of THz Surface Emission in Highly Resistive GaAs (2020)

Irradiation of semiconductor surfaces with femtosecond optical laser pulses is one of the common techniques for broadband, free-space THz transient generation. We demonstrate that the amplitude of surface-emitted THz pulses scales linearly with an applied, external, in-plane magnetic field. We studied the effect in several highly resistive GaAs samples and ascribe it to the Lorentz force that additionally accelerates optically excited carriers.
Chemotherapy with or without plasmapheresis in acute renal failure due to multiple myeloma: a meta-analysis (2015)

Our meta-analysis results showed that plasmapheresis used as an adjunct to chemotherapy had a benefit in the management of dialysisdependent multiple myeloma patients with renal failure.
Dual Function of the NK Cell Receptor 2B4 (CD244) in the Regulation of HCV-Specific CD8+ T Cells (2011)

The outcome of viral infections is dependent on the function of CD8+ T cells which are tightly regulated by costimulatory molecules. The NK cell receptor 2B4 (CD244) is a transmembrane protein belonging to the Ig superfamily which can also be expressed by CD8+ T cells. The aim of this study was to analyze the role of 2B4 as an additional costimulatory receptor regulating CD8+ T cell function and in particular to investigate its implication for exhaustion of hepatitis C virus (HCV)-specific CD8+ T cells during persistent infection. We demonstrate that (i) 2B4 is expressed on virus-specific CD8+ T cells during acute and chronic hepatitis C, (ii) that 2B4 cross-linking can lead to both inhibition and activation of HCV-specific CD8+ T cell function, depending on expression levels of 2B4 and the intracellular adaptor molecule SAP and (iii) that 2B4 stimulation may counteract enhanced proliferation of HCV-specific CD8+ T cells induced by PD1 blockade. We suggest that 2B4 is another important molecule within the network of costimulatory/inhibitory receptors regulating CD8+ T cell function in acute and chronic hepatitis C and that 2B4 expression levels could also be a marker of CD8+ T cell dysfunction. Understanding in more detail how 2B4 exerts its differential effects could have implications for the development of novel immunotherapies of HCV infection aiming to achieve immune control.