gebhart/patrepeval huggingface dataset:
Resequencing and Association Analysis of CLN8 with Autism Spectrum Disorder in a Japanese Population (2015)

Rare variations contribute substantially to autism spectrum disorder (ASD) liability. We recently performed whole-exome sequencing in two families with affected siblings and then carried out a follow-up study and identified ceroid-lipofuscinosis neuronal 8 (epilepsy, progressive with mental retardation) (CLN8) as a potential genetic risk factor for ASD. To further investigate the role of CLN8 in the genetic etiology of ASD, we performed resequencing and association analysis of CLN8 with ASD in a Japanese population. Resequencing the CLN8 coding region in 256 ASD patients identified five rare missense variations: g.1719291G>A (R24H), rs201670636 (F39L), rs116605307 (R97H), rs143701028 (T108M) and rs138581191 (N152S). These variations were genotyped in 568 patients (including the resequenced 256 patients) and 1017 controls. However, no significant association between these variations and ASD was identified. This study does not support a contribution of rare missense CLN8 variations to ASD susceptibility in the Japanese population.
A novel AHI-1–BCR-ABL–DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy (2017)

Tyrosine kinase inhibitor (TKI) therapies induce clinical remission with remarkable effects on chronic myeloid leukemia (CML). However, very few TKIs completely eradicate the leukemic clone and persistence of leukemic stem cells (LSCs) remains challenging, warranting new, distinct targets for improved treatments. We demonstrated that the scaffold protein AHI-1 is highly deregulated in LSCs and interacts with multiple proteins, including Dynamin-2 (DNM2), to mediate TKI-resistance of LSCs. We have now demonstrated that the SH3 domain of AHI-1 and the proline rich domain of DNM2 are mainly responsible for this interaction. DNM2 expression was significantly increased in CML stem/progenitor cells; knockdown of DNM2 greatly impaired their survival and sensitized them to TKI treatments. Importantly, a new AHI-1-BCR-ABL-DNM2 protein complex was uncovered, which regulates leukemic properties of these cells through a unique mechanism of cellular endocytosis and ROS-mediated autophagy. Thus, targeting this complex may facilitate eradication of LSCs for curative therapies.
Polycyclic Aromatic Hydrocarbons Identified in Soot Extracts from Domestic Coal-Burning Stoves of Henan Province, China (2001)

Using high-pressure liquid chromatography with ultraviolet-visible diode-array detection, we have analyzed polycyclic aromatic hydrocarbons (PAH) in the dichloromethane extracts of soot deposits from coal-burning stoves in several homes of Henan Province, China--including Linxian County, where esophageal cancer rates are some of the highest in the world. Thirty-two individual polycyclic aromatic compounds, ranging in size from three to eight fused aromatic rings, have been unequivocally identified among the soot extract components--including 20 benzenoid PAH, 6 fluoranthene benzologues, 1 cyclopentafused PAH, 1 indene benzologue, 3 oxygenated PAH, and 1 ring-sulfur-containing aromatic. Most of the identified compounds have been observed before among the products of laboratory coal pyrolysis experiments, but two of the components, the six-ring C24H14 napthol[1,2-b]fluoranthene and the eight-ring C30H16 tribenzo[e,ghi,k]perylene, have never before been documented as products of coal in any system. All of the Henan coal soot extracts are remarkably similar qualitatively in that they contain the same set of identified PAH, but absolute levels of individual species vary by up to 5 orders of magnitude, from sample to sample. The bulk of the identified component mass in all of these soot extracts lies in the five- and six-ring PAH--the largest single class being the family of five-ring C20H12 isomers, to which the samples' most abundant components, benzo[b]fluoranthene and benzo[e]pyrene, belong. The five- and six-ring PAH also account for the majority of the samples' known mutagens. The three strong mutagens identified in these soot samples are the C20H12 benzo[a]-pyrene and two C24H14 PAH, dibenzo[a,e]pyrene and naphtho-[2,1-a]pyrene. Seven moderate mutagens are found among the C20H12, C22H12, C22H14, and C24H14 PAH. A major class of mutagens, the cyclopenta-fused PAH, appears to be absent from these samples, but our detection of an oxidation product of the major mutagen cyclopenta[cd]- pyrene--itself mutagenic--suggests that these soot deposits may contain additional mutagenic cyclopentafused PAH oxidation products as well.
Superresolved space-dependent sensing of temporal signals by space multiplexing (2020)

In this paper we present a novel, to the best of our knowledge, superresolved sensing concept aiming to improve the resolution of temporal signals obtained by applying space multiplexing. The system's temporal resolution is limited due to the sensor's time averaging. The proposed superresolution technique overcomes this time average and can therefore increase the system's temporal resolution. In addition, we also show how to increase the temporal sampling rate, which also affects the temporal resolution. The proposed concept requires that the object will be fixed in space in order to apply the space multiplexing. It can especially be relevant for superresolving laser-based time-of-flight sensors and images as well as light detection and ranging (lidar) devices.
Antireflection surfaces in silicon using binary optics technology (1992)

Binary optics processing methods were applied to a silicon substrate to generate an array of small pillars in order to enhance transmission. The volume fraction of the silicon in the pillars was chosen to simulate a single homogeneous antireflection layer, and the pillar height was targeted to be a quarter-wave thickness. A mask was generated, using a graphics computer-aided design system; reactive-ion etching was used to generate the pillars. An improvement in long-wavelength infrared transmission is observed, with diffraction and scattering dominating at shorter wavelengths.
Evaluation of ICA-Based ICTD for PolSAR Data Analysis Using a Sliding Window Approach: Convergence Rate, Gaussian Sources, and Spatial Correlation (2016)

Polarimetric incoherent target decomposition aims at accessing physical parameters of illuminated scatters through the analysis of the target coherence or covariance matrix. In this framework, independent component analysis (ICA) was recently proposed as an alternative method to eigenvector decomposition to better interpret non-Gaussian heterogeneous clutter (inherent to high-resolution synthetic aperture radar systems). Until now, the two main drawbacks reported of the aforementioned method are the greater number of samples required for an unbiased estimation, when compared to the classical eigenvector decomposition, and the inability to be employed in scenarios under the Gaussian clutter assumption. In this paper, both drawbacks are analyzed. First, a Monte Carlo approach is performed in order to investigate the bias in estimating Touzi's target-scattering-vector-model parameters when ICA is employed. Simulated data and a RAMSES X-band image acquired over Brétigny, France, are taken into consideration to investigate the bias estimation under different scenarios. Finally, the performance of the algorithm is also evaluated under the Gaussian clutter assumption and when spatial correlation is introduced in the model.
Clinical Epidemiological Study of 553 Patients with Chronic Rhinosinusitis in Japan (2011)

Similar to the relationship between nasal allergy and asthma, CRSwNP may be applicable to the concept of "one airway, one disease".
Packaging of electronic systems : a mechanical engineering approach (1990)

Part I: Foundations for Mechanical Design of Electronic Systems. Part II: Packaging. Part III: Analysis Methods.
Minimum Size of Oxygen Precipitates in Czochralski Silicon Wafers Detected by Improved Light Scattering Tomography (2005)

The minimum size of oxygen precipitates within Czochralski-grown (CZ) Si wafers detectable by light scattering tomography (LST) is completely dependent upon the correctness of the intensity measurement of scattered light, because the intensity is exactly proportional to the size of the precipitates. To assure precise intensity measurement, an adequately adjusted intensity and a well-shaped focusing of the laser beam were realized by instrument enhancement for illumination, and analytical software for brightness correction of and noise elimination from the light scattering tomograms were installed in a computer. With this well-developed system, the minimum diameters of oxygen precipitates in CZ Si wafers detected by improved LST was quantitatively determined using 1.06 µm radiation from a Nd:YAG laser to be 10 nm, compared with oxygen precipitates which were directly measured by transmission electron microscopy (TEM).
The pathology of unusual subtypes of prostate cancer. (2016)

There are some current literatures describing the morphologic change of prostate carcinoma variants. Some subtypes do not respond to hormone deprivation therapy, for example adenosquamous and squamous cell carcinoma (SQCC), basaloid and adenoid cystic carcinoma (ACC), small cell carcinoma (SmCC), sarcomatoid carcinoma, urothelial carcinoma; some are defined in special Gleason grade, some develop different prognosis. So, it is very important to identify these rare subtypes to avoid misdiagnosis. In this review, we aim to describe the typical clinicopathological features of the rare variants of prostate cancer, including prostate acinar adenocarcinoma morphologic variants.
Generic System Calls for GPUs (2018)

GPUs are becoming first-class compute citizens and increasingly support programmability-enhancing features such as shared virtual memory and hardware cache coherence. This enables them to run a wider variety of programs. However, a key aspect of general-purpose programming where GPUs still have room for improvement is the ability to invoke system calls. We explore how to directly invoke system calls from GPUs. We examine how system calls can be integrated with GPGPU programming models, where thousands of threads are organized in a hierarchy of execution groups. To answer questions on GPU system call usage and efficiency, we implement Genesys, a generic GPU system call interface for Linux. Numerous architectural and OS issues are considered and subtle changes to Linux are necessary, as the existing kernel assumes that only CPUs invoke system calls. We assess the performance of Genesys using micro-benchmarks and applications that exercise system calls for signals, memory management, filesystems, and networking.
The genetic revolution and medicine in the 21st century (1997)

We are currently in the midst of a revolution in our understanding of human disease. The greater understanding that has been achieved of many inherited diseases is giving insights into many more common conditions not previously regarded as ‘inherited’. An individual can be identified from a DNA fingerprint obtained from the analysis of a very small DNA sample in a hair root, mouth wash or a blood spot. By the turn of the century, we will know the sequences of most, if not all, human genes. We will have the ‘recipe’ of human life. We may not be able to develop treatments for some years, but we will have the tools for identifying those predisposed to disease. Although the use of genetic tests raises many social, ethical, legal and economic issues, this potential is already with us and we cannot ignore it. Society should already openly be debating the implications of genetic knowledge so that the enormous benefits to human health can be gained without too many suffering from misuse of the technology.
ChemInform Abstract: P‐TOLYLKETENYL AS A NEW TYPE OF DIHAPTO 3‐ELECTRON LIGAND (1977)

Abstract Der Ketenylkomplex (I) ‐ entstanden durch Umsetzung von Dicarbonyl‐(cyclopentadienyl)‐p‐toly1carbin‐ Wolfram mit Trimethylphosphin ‐ spaltet in Lösung bei Raumtemperatur einen Phosphinliganden ab unter Bildung des neuartigen Komplexes (II).
Spatial and temporal coordination of traction forces in one-dimensional cell migration (2016)

Migration of a fibroblast along a collagen fiber can be regarded as cell locomotion in one-dimension (1D). In this process, a cell protrudes forward, forms a new adhesion, produces traction forces, and releases its rear adhesion in order to advance itself along a path. However, how a cell coordinates its adhesion formation, traction forces, and rear release in 1D migration is unclear. Here, we studied fibroblasts migrating along a line of microposts. We found that when the front of a cell protruded onto a new micropost, the traction force produced at its front increased steadily, but did so without a temporal correlation in the force at its rear. Instead, the force at the front coordinated with a decrease in force at the micropost behind the front. A similar correlation in traction forces also occurred at the rear of a cell, where a decrease in force due to adhesion detachment corresponded to an increase in force at the micropost ahead of the rear. Analysis with a bio-chemo-mechanical model for traction forces and adhesion dynamics indicated that the observed relationship between traction forces at the front and back of a cell is possible only when cellular elasticity is lower than the elasticity of the cellular environment.
Flavonoids with mosquito larval toxicity (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFlavonoids with mosquito larval toxicityKoppaka V. Rao, Sunil K. Chattopadhyay, and G. Chandrasekhara ReddyCite this: J. Agric. Food Chem. 1990, 38, 6, 1427–1430Publication Date (Print):June 1, 1990Publication History Published online1 May 2002Published inissue 1 June 1990https://pubs.acs.org/doi/10.1021/jf00096a028https://doi.org/10.1021/jf00096a028research-articleACS PublicationsRequest reuse permissionsArticle Views280Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of structural relaxation and oxidation conditions on interlayer exchange coupling in Fe|MgO|Fe tunnel junctions (2010)

The effect of structural relaxation and interfacial oxidation is demonstrated from first principles to have a crucial impact on interlayer exchange coupling (IEC) in crystalline Fe|MgO|Fe magnetic tunnel junctions (MTJs). It is shown that the IEC becomes antiferromagnetic for the relaxed structure in contrast to ferromagnetic for unrelaxed Fe|MgO|Fe MTJs. Furthermore, the antiferromagnetic IEC is strongly enhanced in the presence of oxygen vacancies while it is decreased by overoxidation and may even become ferromagnetic for sufficiently high oxygen concentration at the Fe∣MgO interface. These results were supported using a tight-binding model and provide an explanation for recent experimental studies.
Slip-shakedown analysis and the assumption of small coupling in frictional contact (2008)

In the frictional contact of solids under cyclic loads, the shakedown behaviour of the relative displacement is of interest in the same spirit as the plastic deformation in plasticity. Cumulative slips may lead to the failure due to large relative displacements of the components of an assembly while cyclic slips are often undesired because of wear and fretting÷fatigue problems. Under Coulomb friction, it is well known that Melan and Koiter theorems are generally not available, except in certain particular cases. In this discussion, the particular case of small coupling between the contact pressures and the slip-displacements is considered. This assumption means that the tangent displacements have small or no influence on the contact pressures which can be then computed from the elastic response as in the uncoupling case. The pressure is thus a given time-dependent function and the Coulomb criterion is reduced to a Mises-like standard law of friction. It is shown here that Melan and Koiter theorems can be applied again as in standard plasticity. The dependence of the yield limit on the loading amplitude is however not classical and the extension of the static and kinematic approaches is discussed to obtain the critical shakedown load or the limit load. The validity of the assumption of small coupling is also explored by numerical simulation in a practical example.
THIGH MASS AND LYTIC DIAPHYSEAL FEMORAL LESION ASSOCIATED WITH POLYETHYLENE WEAR AFTER HYBRID TOTAL KNEE ARTHROPLASTY (2006)

1 Resurgens Orthopaedics, PC, 5671 Peachtree Dunwoody Road, Suite #700, Atlanta, GA 30342 2 Department of Orthopaedics, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115
Weld seam tracking and lap weld penetration monitoring using the optical spectrum of the weld plume (1996)

Joining of dissimilar materials is a long standing problem in manufacturing, with many tricks and special techniques developed to successfully join specific pairs of materials. Often, these special techniques impose stringent requirements on the process such as precise control of process parameters to achieve the desired joint characteristics.Laser welding is one of the techniques which has had some success in welding dissimilar metal alloys, and appears to be a viable process for these materials. Minimal heat input limits differential thermal expansion, and the small weld pool allows precise control of alloy mixing in the fusion zone. Obtaining optimal weld performance requires accurate monitoring and control of absorbed laser power and weld focus position.In order to monitor the laser welding process, we have used a small computer controlled optical spectrometer to observe the emission from the weld plume. Absorbed laser power can be related to the temperature of the weld pool surface and the plume above the weld. Focus position relative to the joint can easily be seen by the proportion of elements from each material existing in the plume.This monitor has been used to observe and optimize the performance of butt and lap welds between dissimilar alloys, where each alloy contains at least one element not found in the other alloy. Results will be presented for a copper-steel butt joint and a lap weld between stainless and low alloy steels.
Accuracy and reproducibility of the 4-hour ATB 32A method for anaerobe identification (1989)

The ATB 32A system (API System SA, La Balme les Grottes, Montalieu-Vercieu, France) was evaluated for use in the identification of 214 anaerobes. Organisms included 73 isolates of the Bacteroides fragilis group, 24 Bacteroides spp., 10 fusobacteria, 43 clostridia, 28 cocci, and 36 gram-positive, nonsporeforming rods. With the concomitant use of Gram stain, pigmentation, catalase testing, and aerobic growth, the ATB 32A system correctly identified 97% of the B. fragilis group isolates, 88% of Bacteroides spp., 50% of fusobacteria, 74% of clostridia, 100% of cocci, and 86% of the gram-positive, nonsporeforming rods. Overall, 188 strains (88%) were correctly identified, with 18 (8%) requiring extra tests, other than the four mentioned above, for correct identification. Eight strains were misidentified, including one Bacteroides sp., three fusobacteria, one Clostridium sp., and three gram-positive, nonsporeforming rods. Reproducibility was very good, with 12 of 14 strains (86%) tested in triplicate yielding identical correct results on each of three occasions and 2 strains (14%) yielding identical correct results on two occasions. There was a low-probability identification (including the correct species) on the third testing. The ATB 32A system represents a worthwhile advance in systems used for the identification of clinically significant anaerobic bacteria.
Curing kinetics and viscosity change of a two‐part epoxy resin during mold filling in resin‐transfer molding process (2000)

The curing kinetics and the resulting viscosity change of a two-part epoxy/amine resin during the mold-filling process of resin-transfer molding (RTM) of composites was investigated. The curing kinetics of the epoxy/amine resin was analyzed in both the dynamic and the isothermal modes with differential scanning calorimetry (DSC). The dynamic viscosity of the resin at the same temperature as in the mold-filling process was measured. The curing kinetics of the resin was described by a modified Kamal kinetic model, accounting for the autocatalytic and the diffusion-control effect. An empirical model correlated the resin viscosity with temperature and the degree of cure was obtained. Predictions of the rate of reaction and the resulting viscosity change by the modified Kamal model and by the empirical model agreed well with the experimental data, respectively, over the temperature range 50–80°C and up to the degree of cure α = 0.4, which are suitable for the mold-filling stage in the RTM process. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 77: 2139–2148, 2000
Optical Interconnects for High-Performance Computing Systems (2012)

A first step toward advanced optical interconnect technologies is a data-center switch using a multibus optical backplane. This network switch replaces the electronic backplane and communications fabric application-specific integrated circuit (ASIC) with an optical fabric based on multiple optical broadcast buses. The prototype demonstrated reliable performance, and the optical bus can scale to much higher bandwidths. Thus, network switches using optical backplanes have significant advantages for future systems.
Comparison of femoral stem subsidence between three types of press‐fit cementless total hip replacement in dogs (2020)

Implantation of a lateral bolt femoral stem should be considered during THR to prevent subsidence.