gebhart/patrepeval huggingface dataset:
Usefulness of staging chest-CT in patients with operable breast cancer (2021)

Objective The aim of this study was to investigate the usefulness of staging chest-CT in terms of diagnostic yield and false-referral rate in patients with operable breast cancer. Materials and methods This study was approved by the institutional review border. In this retrospective study, we reviewed patients who underwent staging chest-CT between January 2014 and June 2016. Reference standard was defined as a combination of pathology and radiologic tumor changes in accordance with primary tumor or metastatic lesions and stability during the 12-month follow-up period. We calculated diagnostic yield and false-referral rates stratified by pathologic stage. The important ancillary findings of staging chest-CT were also recorded. Results A total of 1,342 patients were included in this study. Of these, four patients (0.3%; 4/1342) had true pulmonary metastasis. Diagnostic yields of stage I, II, III disease were 0.0% (0/521), 0.3% (2/693), and 1.6% (2/128), respectively. The overall false-referral rate was 4.6% (62/1342); false-referral rates of stage I, II, and III disease were 5.0% (26/521), 3.8% (26/693), and 7.8% (10/128), respectively. No occult thoracic metastasis occurred within 12 months of staging chest-CT. Nineteen patients showed significant ancillary findings besides lung metastasis, including primary lung cancer (n = 9). The overall diagnostic yield of ancillary findings was 1.7% (23 of 1342). Conclusions The incidence of pulmonary metastasis was near zero for pathologic stages I/II and slightly higher (although still low; 1.6%). for stage III. Considering its low diagnostic yield and substantial false-referral rates, staging chest-CT might not be useful in patients with operable breast cancer.
Robust Online Dynamic Security Assessment Using Adaptive Ensemble Decision-Tree Learning (2013)

Online dynamic security assessment (DSA) is examined in a data-mining framework by taking into account the operating condition (OC) variations and possible topology changes of power systems during the operating horizon. Specifically, a robust scheme is proposed based on adaptive ensemble decision tree (DT) learning. In offline training, a boosting algorithm is employed to build a classification model as a weighted voting of multiple unpruned small-height DTs. Then, the small-height DTs are periodically updated by incorporating new training cases that account for OC variations or the possible changes of system topology; the voting weights of the small-height DTs are also updated accordingly. In online DSA, the updated classification model is used to map the real-time measurements of the present OC to security classification decisions. The proposed scheme is first illustrated on the IEEE 39-bus test system, and then applied to a regional grid of the Western Electricity Coordinating Council (WECC) system. The results of case studies, using a variety of realized OCs, illustrate the effectiveness of the proposed scheme in dealing with OC variation and system topology change.
The 1,4-benzodiazepine Ro5-4864 (4-chlorodiazepam) suppresses multiple pro-inflammatory mast cell effector functions (2013)

Activation of mast cells (MCs) can be achieved by the high-affinity receptor for IgE (FcεRI) as well as by additional receptors such as the lipopolysaccharide (LPS) receptor and the receptor tyrosine kinase Kit (stem cell factor [SCF] receptor). Thus, pharmacological interventions which stabilize MCs in response to different receptors would be preferable in diseases with pathological systemic MC activation such as systemic mastocytosis. 1,4-Benzodiazepines (BDZs) have been reported to suppress MC effector functions. In the present study, our aim was to analyze molecularly the effects of BDZs on MC activation by comparison of the effects of the two BDZs Ro5-4864 and clonazepam, which markedly differ in their affinities for the archetypical BDZ recognition sites, i.e., the GABAA receptor and TSPO (previously termed peripheral-type BDZ receptor). Ro5-4864 is a selective agonist at TSPO, whereas clonazepam is a selective agonist at the GABAA receptor. Ro5-4864 suppressed pro-inflammatory MC effector functions in response to antigen (Ag) (degranulation/cytokine production) and LPS and SCF (cytokine production), whereas clonazepam was inactive. Signaling pathway analyses revealed inhibitory effects of Ro5-4864 on Ag-triggered production of reactive oxygen species, calcium mobilization and activation of different downstream kinases. The initial activation of Src family kinases was attenuated by Ro5-4864 offering a molecular explanation for the observed impacts on various downstream signaling elements. In conclusion, BDZs structurally related to Ro5-4864 might serve as multifunctional MC stabilizers without the sedative effect of GABAA receptor-interacting BDZs.
Stoichiometry Determination of the MP1−p14 Complex Using a Novel and Cost-Efficient Method To Produce an Equimolar Mixture of Standard Peptides (2009)

Determination of protein complex stoichiometry can be achieved by absolute quantification of the interacting constituents based on isotope dilution mass spectrometry. Current available platforms for the generation of standard peptides are cost-intensive and deliver variable results concerning the equimolarity of the standard peptides. Here we describe a novel and cost-efficient method to generate an equimolar mixture of standard peptides, which we call the equimolarity through equalizer peptide (EtEP) strategy. The rationale of the strategy allows equalization of internal standard peptides and absolute quantification of any protein of interest via a single peptide, from which the exact amount was determined by amino acid analysis. This and the use of the mTRAQ reagent significantly decrease the costs of absolute quantification and stoichiometry determination. We used the EtEP strategy to determine the MP1-p14 complex stoichiometry of two different concentrations, one simulating a condition following tandem affinity purification. Absolute quantification of MP1-p14 was performed on two different mass spectrometers, and the 1:1 stoichiometry was confirmed with high accuracy and precision. On the basis of the quantification of MP1-p14, we demonstrate the importance to assess completeness of protein digestion and discuss the use of peptides containing labile amino acids and the choice of instrumentation.
Chromatographic separation of the urinary metabolites of the carcinogen N-2-fluorenylacetamide into free compounds, sulfuric acid, and glucuronic acid esters. (1961)

The urinary metabolites of N -2-fluorenylacetamide were separated by chromatography on an alumina column into three classes: ( a ) unconjugated materials, amounting to 5–10 per cent of the urinary activity; ( b ) sulfuric acid conjugates (20–25 per cent); ( c ) glucuronic acid conjugates (60–70 per cent). Evidence for the structure of these materials was adduced by solvent partition, paper chromatography, and hydrolysis by acid and by appropriate enzymes. Taka-diastase, often used to split sulfuric acid esters, did not quantitatively hydrolyze the sulfates of metabolites of N -2-fluorenylacetamide under our experimental conditions.
Scattering of light halo nuclei on heavy target at energies around the Coulomb barrier (2014)

We report here on experiments performed at TRIUMF to study the scattering of the light halo nuclei 11Li on lead at energies below and around the Coulomb barrier. The the elastic and break-up differential cross section are interpreted in the framework of Continuum-Discretized Coupled-Channel calculations. The departure from Rutherford scattering at energies below the barrier is well beyond the behavior of normal nuclei.
The Role of Pea Chloroplast [alpha]-Glucosidase in Transitory Starch Degradation (1995)

Pea chloroplastic [alpha]-glucosidase (EC 3.2.1.20) involved in transitory starch degradation was purified to apparent homogeneity by ion exchange, reactive dye, hydroxylapatite, hydrophobic interaction, and gel filtration column chromatography. The native molecular mass and the subunit molecular mass were about 49.1 and 24.4 kD, respectively, suggesting that the enzyme is a homodimer. The enzyme had a Km of 7.18 mM for maltose. The enzyme's maximal activity at pH 7.0 and stability at pH 6.5 are compatible with the diurnal oscillations of the chloroplastic stromal pH and transitory starch accumulation. This pH modulation of the [alpha]-glucosidase's activity and stability is the only mechanism known to regulate starch degradative enzymes in leaves. Although the enzyme was specific for the [alpha]-D-glucose in the nonreducing end as the glycon, the aglycon moieties could be composed of a variety of groups. However, the hydrolysis rate was greatly influenced by the aglycon residues. Also, the enzyme could hydrolyze glucans in which carbon 1 of the glycon was linked to different carbon positions of the penultimate glucose residue. The ability of the [alpha]-glucosidase to hydrolyze [alpha]-1,2- and [alpha]-1,3-glucosidic bonds may be vital if these bonds exist in starch granules because they would be barriers to other starch degradative enzymes. This purified pea chloroplastic [alpha]-glucosidase was demonstrated to initiate attacks on native transitory chloroplastic starch granules.
Highly Porous Paper Loading with Microfibrillated Cellulose by Spray Coating on Wet Substrates (2014)

International audience
Lipoic acid restores age‐associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway (2013)

This study examines the progress of a hypometabolic state inherent in brain aging with an animal model consisting of Fischer 344 rats of young, middle, and old ages. Dynamic microPET scanning demonstrated a significant decline in brain glucose uptake at old ages, which was associated with a decrease in the expression of insulin-sensitive neuronal glucose transporters GLUT3/4 and of microvascular endothelium GLUT1. Brain aging was associated with an imbalance between the PI3K/Akt pathway of insulin signaling and c-Jun N-terminal kinase (JNK) signaling and a downregulation of the PGC1α-mediated transcriptional pathway of mitochondrial biogenesis that impinged on multiple aspects of energy homeostasis. R-(+)-lipoic acid treatment increased glucose uptake, restored the balance of Akt/JNK signaling, and enhanced mitochondrial bioenergetics and the PGC1α-driven mitochondrial biogenesis. It may be surmised that impairment of a mitochondria-cytosol-nucleus communication is underlying the progression of the age-related hypometabolic state in brain; the effects of lipoic acid are not organelle-limited, but reside on the functional and effective coordination of this communication that results in improved energy metabolism.
A Service Architecture for Mobile Teamwork (2003)

Mobile teamwork has become an emerging requirement in the daily business of large enterprises. Employees collaborate across locations and need team support while they are on the move. Business documents and expertise need to be shared independent of the actual location or connectivity (e.g., access through a mobile phone, laptop, Personal Digital Assistant, etc.) of employees. Although many collaboration tools and systems exist, most do not deal with new demanding requirements such as locating artifacts and experts through distributed searches, advanced information subscription and notification, and mobile information sharing and access. The MOTION service architecture that we have developed supports mobile teamwork by taking into account the different connectivity modes of users, provides access support for various devices such as laptop computers and mobile phones, and uses XML meta data and the XML Query Language (XQL) for distributed searches and subscriptions. In this article, we describe the architecture and the components of our generic MOTION services platform for building collaborative applications. The MOTION platform is currently being evaluated in two large industry case-studies.
Long-Term Blood Pressure Variability in Young Adulthood and Coronary Artery Calcium and Carotid Intima-Media Thickness in Midlife (2020)

Recent evidence links long-term (visit-to-visit) blood pressure (BP) variability to the risk of cardiovascular disease, independent of mean BP levels. Potential associations between long-term BP variability and cardiovascular disease risk may be reflected in early life course alterations in coronary artery calcium (CAC) and carotid intima-media thickness. We evaluated 2482 CARDIA study (Coronary Artery Risk Development in Young Adults) participants (mean [SD] age at the year 20 exam [2005-2006] was 45.4 [3.6] years, 43.2% men, and 41.3% black). We included participants with BP assessments across 20-years (year 0, 2, 5, 7, 10, 15, 20 exams) and carotid intima-media thickness and CAC data at the year 20 exam. BP variability was assessed using variability independent of the mean and SD. Adjusted multivariable linear or logistic regression models (as appropriate) were used to assess associations between long-term BP variability measures and carotid intima-media thickness. and CAC (ln [CAC+1] and prevalent CAC). Long-term systolic BP variability independent of the mean (per 1 SD) was positively associated with carotid intima-media thickness (β=10 μm, SE=3, <i>P</i>=0.002). Similarly, long-term diastolic BP variability independent of the mean was associated with carotid intima-media thickness (β=10 μm, SE (3), <i>P</i>=0.001). Long-term BP variability was not associated with either ln [CAC+1] or prevalent CAC. Long-term systolic and diastolic BP variability across early adulthood was positively associated with modest adverse midlife alterations in carotid intima-media thickness but not to CAC. Our findings provide further insights into pathophysiologic mechanisms that link long-term BP variability to cardiovascular disease.
Direct-laser metal writing of surface acoustic wave transducers for integrated-optic spatial light modulators in lithium niobate (2017)

Recently, the fabrication of high-resolution silver nanostructures using a femtosecond laser-based direct write process in a gelatin matrix was reported. The application of direct metal writing towards feature development has also been explored with direct metal fusion, in which metal is fused onto the surface of the substrate via a femtosecond laser process. In this paper, we present a comparative study of gelatin matrix and metal fusion approaches for directly laser-written fabrication of surface acoustic wave transducers on a lithium niobate substrate for application in integrated optic spatial light modulators.
Laser-controlled local magnetic field with semiconductor quantum rings (2005)

We analyze theoretically the dynamics of $N$ electrons localized in a narrow semiconductor quantum ring under a train of phase-locked infrared laser pulses. The pulse sequence is designed to control the total angular momentum of the electrons. The quantum ring can be put in states characterized by strong currents. The local magnetic field created by these currents can be used for a selective quantum control of single spins in semiconductor systems. The current generation in quantum rings with finite width is also studied.
High-Temperature Operation of Oxygen Electrode Giving Fast Response for Respiratory Gas Sampling (1963)

Abstract The 98% response time of the membrane-covered Clark-type polarographic oxygen electrode may be reduced to 0.4 sec. by heating the electrode and the gas sample flowing past it to 80° when the electrode is covered with 0.25-mil (6 µ) Teflon membrane. The design of the microcathode electrode has been modified slightly to prevent drying out of the electrolyte and pressure changes within the electrolyte cavity. The relationship of output current to temperature approaches a plateau at this temperature which suggests that for reasonably accurate operation, temperature regulation may not be as crucial as it is at body temperature.
Comparison of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy with Mitomycin or Carboplatin for Diffuse Malignant Peritoneal Mesothelioma (2014)

Diffuse malignant peritoneal mesothelioma is a rare, aggressive disease. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have improved outcomes where systemic chemotherapy has not succeeded. In this study, we compare outcomes of patients treated with mitomycin or carboplatin as perfusate. In this retrospective study, 47 procedures (CRS + HIPEC) were conducted on 44 patients between March 2003 and August 2010 with either mitomycin or carboplatin. χ(2) and Student's t test were used for comparison of clinicopathological variables and Kaplan-Meier curves and log rank test were used to compare overall survival. Median survival of the mitomycin group was 18 months with 1- and 5-year survivals of 72.3 and 27.3 per cent, respectively. Median survival of the carboplatin group was not reached and 1- and 5-year survivals were 89.7 and 62.5 per cent, respectively (P = 0.014). Mean hospital and intensive care unit length of stay was 18.9 and 8.7 days in the mitomycin group and 12.5 and 2.3 days in the carboplatin group (P = 0.0069). Mean number of packed red blood cell units transfused was higher in the mitomycin group compared with the carboplatin group (3.54 vs 0.83, P < 0.05). There was no postoperative mortality. HIPEC with carboplatin in diffuse malignant peritoneal mesothelioma is associated with improved overall survival and shorter hospital stay compared with HIPEC with mitomycin.
Introduction (2019)

research-article Share on Introduction Authors: Dahlia Malkhi View Profile , Idit Keidar View Profile Authors Info & Claims Concurrency: the Works of Leslie LamportOctober 2019 Pages 1–12https://doi.org/10.1145/3335772.3335774Published:04 October 2019Publication History 0citation96DownloadsMetricsTotal Citations0Total Downloads96Last 12 Months2Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Gender-dependent pharmacokinetics of topotecan in adult patients (2000)

Gender-dependent differences in the clinical pharmacokinetic behavior of various drugs have been documented previously. Most commonly, these differences are associated with differences in body composition, renal elimination, drug absorption or hepatic metabolism. Gender-dependent differences in the pharmacokinetics of topotecan (Hycamtin) have not yet been described. In this report, pharmacokinetic data of the lactone and carboxylate forms of topotecan were derived from clinical studies in which topotecan was administered either orally or i.v. to a total of 55 males and 37 females. A significant difference (p=0.0082) of 38% was found between the apparent clearance of topotecan lactone after oral administration in males (237+/-105 l/h) and females (163+/-62.5 l/h). When adjusted for body surface area, this difference remained significant (p=0.031). Similarly, differences were noted in the percentage of topotecan in the lactone form (37.1+/-5.32 versus 41.7+/-6.51%, p=0.0076). Statistical analysis revealed that individual hematocrit values, which were consistently lower in females (p<0.023), were a significant predictor of the apparent topotecan lactone clearance. This was confirmed experimentally in in vitro incubation studies in whole blood using artificially altered hematocrit values and in blood samples from both male and female volunteers. Topotecan is thus subject to significant gender-dependent differences in pharmacokinetics that arise as a result of a physiological difference in hematocrit values between males and females. This finding may have significant implications for the interpretation of the relationships between pharmacokinetics and pharmacodynamic outcome of topotecan treatment, and may provide a basis for the development and refinement of future clinical protocols.
Bildungsbiografien von Kindern, Teenies und Jugendlichen im Kontext ihrer Peers (2013)

Sammelrezension: (1) Heinz-Hermann Krüger, Sina-Mareen Köhler, Maren Zschach, Nicolle Pfaff: Kinder und ihre Peers. Freundschaftsbeziehungen und schulische Bildungsbiographien. Opladen, Farmington Hills: B. Budrich 2008, 319 S. ISBN 978-3-86649-114-4. (2) Heinz-Hermann Krüger, Sina-Mareen Köhler, Maren Zschach: Teenies und ihre Peers. Freundschaftsgruppen, Bildungsverläufe und soziale Ungleichheit. Opladen, Farmington Hills: B. Budrich 2010, 278 S. ISBN 978-3-86649-312-4. (3) Heinz-Hermann Krüger, Aline Deinert, Maren Zschach: Jugendliche und ihre Peers. Freundschaftsbeziehungen und Bildungsbiografien in einer Längsschnittperspektive. Opladen, Farmington&#13;\nHills: B. Budrich 2012, 292 S. ISBN 978-3-86649-460-2.
PI-RADSv2.1: Current status (2020)

Multiparametric magnetic resonance imaging (mpMRI) has played an increasing role in the detection and local staging of prostate cancer over the last 15 years. Prostate mpMRI, due to various factors, is prone to high inter-reader variability necessitating standardized reporting guidelines that provide accurate and actionable information to the ordering clinician. The Prostate Imaging-Reporting and Data System version 2.1 (PI-RADSv2.1) was released in March 2019 as an update to PI-RADSv2.0 with the hope of further standardizing the reporting process of prostate mpMRI, improving the detection of clinically significant cancer, reducing the biopsy rate of indolent tumors, and decreasing inter-reader variability. Early data show an improved performance of PI-RADSv2.1 over PI-RADSv2.0. Updates included in PI-RADSv2.1 and its current experience in clinic will be reviewed in this review.
A New Luminescent Cd(II) Coordination Polymer Constructed from 1,3,5-Benzenetricarboxylic Acid and bis(imidazole)-Based Ligand (2013)

A new luminescent Cd(II) coordination polymer, namely [Cd3(btc)2(bix)2)]n·2nH2O (1 H3btc = 1, 3, 5-benzenetricarboxylic acid, bix = 4,4′-bis(imidazol-1-ylmethyl)benzene), has been successfully synthesized and structurally characterized. Single-crystal X-ray analysis reveals that 1 is a three-dimensional (3D) complicated framework and can be simplified into a (4, 5, 5)-connected topological network based on three unequivalent nodes. In addition, the luminescent property of this compound was also investigated in the solid state at room temperature.