gebhart/patrepeval huggingface dataset:
The Evolution of Targeted Radionuclide Diagnosis of HER2-Positive Breast Cancer (2022)

This review examines the evolution of the radionuclide diagnosis of HER2-positive breast cancer using various compounds as a targeting module in clinical practice: from full-length antibodies to a new group of small synthetic proteins called alternative scaffold proteins. This topic is of especial relevance today in view of the problems attendant to the detection of breast cancer with HER2/neu overexpression, which, in most cases, introduce errors in the treatment of patients. The results of clinical studies of radiopharmaceuticals based on affibody molecules, ADAPTs, and DARPins for SPECT and PET have demonstrated good tolerability of the compounds, their rapid excretion from the body, and the possibility to differentiate tumor sites depending on the HER2/neu status. This indicates that targeted radionuclide diagnosis holds promise and the need to continue research in this direction.
Vapor−Liquid Hybrid Deposition Process for Device-Quality Metal Oxide Film Growth (2003)

Ultrathin metal oxide films with electrical properties suitable for gate dielectrics application have been formed by a new room-temperature deposition process which combines adsorption of metal-containing precursors from the vapor phase with liquid-phase hydrolysis.
Dyskinesia after fetal cell transplantation for parkinsonism: A PET study (2002)

Persistent dyskinesias in the absence of or with only minimal amounts of dopaminergic medication have been reported after dopamine cell implantation for Parkinson's disease. In this study, we used [(18)F]fluorodopa (FDOPA) and positron emission tomography to determine whether this complication resulted from specific alterations in dopamine function after transplantation. Caudate and putamen FDOPA uptake values in these patients (DYS+, n = 5) were compared with those obtained in a cohort of age- and disease duration-matched transplant recipients who did not develop this complication (DYS-, n = 12). PET signal for both groups was compared at baseline and at 12 and 24 months after transplantation. We found that putamen FDOPA uptake was significantly increased (p < 0.005) in DYS+ transplant recipients. These increases were predominantly localized to two zones within the left putamen. In addition to the posterodorsal zone in which a prominent reduction in FDOPA uptake was present at baseline, the DYS+ group also displayed a relative increase ventrally, in which preoperative dopaminergic input was relatively preserved. Postoperative FDOPA uptake did not reach supranormal values over the 24-month follow-up period. These findings suggest that unbalanced increases in dopaminergic function can complicate the outcome of neuronal transplantation for parkinsonism.
Correction: Convective heat transfer in a measurement cell for scanning electrochemical microscopy (2018)

Correction for 'Convective heat transfer in a measurement cell for scanning electrochemical microscopy' by Javor K. Novev et al., Phys. Chem. Chem. Phys., 2016, 18, 29836-29846.
The Limits of Serial Surveillance Cultures in Predicting Clearance of Colonization with Carbapenemase-Producing Enterobacteriaceae (2015)

An accepted practice for patients colonized with multidrug-resistant organisms is to discontinue contact precautions following 3 consecutive negative surveillance cultures. Our experience with surveillance cultures to detect persistent carbapenemase-producing Enterobacteriaceae (CPE) colonization suggests that extrapolation of this practice to CPE-colonized patients may not be appropriate.
U.S. Navy Protective Clothing Program (1986)

The Navy Clothing and Textile Research Facility is involved in a major effort to develop fire retardant-heat protective clothing for Navy shipboard personnel encompassing both work and special protective clothing. To determine the degree of protection afforded by the various articles of clothing being developed, both laboratory and field testing have been employed. Laboratory material tests have included vertical flammability resistance tests and protection time determinations for flame impingement exposure. Field tests have involved exposure of garments to total flame envelopment utilizing manikins equipped with paper tape temperature sensors to estimate the extent of burn injury sustained. The usefulness of laboratory tests such as flame impingement tests to predict material/clothing performance under more realistic fire threat conditions is limited because of differences in exposure conditions between laboratory tests and full-scale fire tests. Laboratory tests do, however, provide an extremely useful screening tool to limit the number of candidate systems to be evaluated under field conditions. This paper covers the nature of some of the clothing systems being developed, the laboratory and field evaluation procedures employed, and some of the laboratory and field test data accumulated on the materials and clothing items investigated.
The clinical evaluation of cancer chemoprevention agents: defining and contrasting phase I, II, and III objectives. (1992)

A number of potential chemoprevention agents are now in clinical trials to evaluate their efficacy. A larger number of compounds await clinical investigation. The design of phase I and phase II trials for cancer chemoprevention agents requires a different approach than for cytotoxic agents. The unique nature of the target populations, the scope of side effect evaluation, and the potential duration of treatment must be considered in the design of these trials. This article will discuss the effect these variables have on the evaluation of a chemoprevention agent and propose models for the phase I and phase II trials of chemoprevention agents.
Formation reconfiguration for mobile robots with network connectivity constraints (2012)

Future systems of networked autonomous vehicles, such as unmanned aerial or ground vehicles, may rely on peer-to-peer wireless communication to coordinate their actions. The physical formation of the network may need to be reconfigured at times based on the specified missions. However, reconfiguring the physical formation also impacts the link connectivity and hence the connectivity of the network. If the network is partitioned, the autonomous vehicles can no longer coordinate their movements, and the mission may fail. In this article, we discuss techniques to transform the formation of a system of autonomous vehicles while preserving network connectivity. Several different approaches to address this problem are presented, with the focus on a method that utilizes ideas from routing packets in networks. We also briefly discuss the problem of formation selection and give an example of formation optimization in which communication costs are minimized under constraints on preserving network connectivity and the amount of movement required.
Supplementary Data from Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery (2023)

&lt;p&gt;ST1, ST2, Note on Prevalence, SF1, SF2, SF3, Note on Elastography&lt;/p&gt;
Synthesis of New 1-Aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone Oxime Ether Derivatives and Investigation of Their Cytotoxic Effects (2021)

In this study, 12 new 1-aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone oxime ether derivatives were designed and synthesized to investigate their cytotoxic effects. The in vitro cytotoxic activities of the compounds were evaluated against cervix, colon, breast, glioma, neuroblastoma, and lung cancer cell lines, as well as a healthy cell line using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazo-lium bromide (MTT) assays with 5-fluorouracil (5-FU) as the reference compound. Compound 5f (IC50 = 5.13 µM) was found to be more effective than 5-FU (IC50 = 8.34 µM) in the C6 cancer cell line, and it had no cytotoxic effect on the L929 healthy cell line. Flow cytometry was used to investigate the mechanism of action of compound 5f on the cell cycle of the C6 cell line. The analysis showed that cell death was significantly due to apoptosis. These results indicate that compound 5f induces cell cycle arrest, and may be effective in treating glioma.
Temporal characterization of femtosecond laser pulses using tunneling ionization in the UV, visible, and mid-IR ranges (2019)

To generalize the applicability of the temporal characterization technique called "tunneling ionization with a perturbation for the time-domain observation of an electric field" (TIPTOE), the technique is examined in the multicycle regime over a broad wavelength range, from the UV to the IR range. The technique is rigorously analyzed first by solving the time-dependent Schrödinger equation. Then, experimental verification is demonstrated over an almost 5-octave wavelength range at 266, 1800, 4000 and 8000 nm by utilizing the same nonlinear medium - air. The experimentally obtained dispersion values of the materials used for the dispersion control show very good agreement with the ones calculated using the material dispersion data and the pulse duration results obtained for 1800 and 4000 nm agree well with the frequency-resolved optical gating measurements. The universality of TIPTOE arises from its phase-matching-free nature and its unprecedented broadband operation range.
Reductive Umpolung of Carbonyl Derivatives with Visible‐Light Photoredox Catalysis: Direct Access to Vicinal Diamines and Amino Alcohols via α‐Amino Radicals and Ketyl Radicals (2016)

Visible-light-mediated photoredox-catalyzed aldimine-aniline and aldehyde-aniline couplings have been realized. The reductive single electron transfer (SET) umpolung of various carbonyl derivatives enabled the generation of intermediary ketyl and α-amino radical anions, which were utilized for the synthesis of unsymmetrically substituted 1,2-diamines and amino alcohols.
Two years of Visual Odometry on the Mars Exploration Rovers (2007)

Abstract NASA's two Mars Exploration Rovers (MER) have successfully demonstrated a robotic Visual Odometry capability on another world for the first time. This provides each rover with accurate knowledge of its position, allowing it to autonomously detect and compensate for any unforeseen slip encountered during a drive. It has enabled the rovers to drive safely and more effectively in highly sloped and sandy terrains and has resulted in increased mission science return by reducing the number of days required to drive into interesting areas. The MER Visual Odometry system comprises onboard software for comparing stereo pairs taken by the pointable mast‐mounted 45 deg FOV Navigation cameras (NAVCAMs). The system computes an update to the 6 degree of freedom rover pose ( x , y , z , roll, pitch, yaw) by tracking the motion of autonomously selected terrain features between two pairs of 256×256 stereo images. It has demonstrated good performance with high rates of successful convergence (97% on Spirit, 95% on Opportunity), successfully detected slip ratios as high as 125%, and measured changes as small as 2 mm, even while driving on slopes as high as 31 deg. Visual Odometry was used over 14% of the first 10.7 km driven by both rovers. During the first 2 years of operations, Visual Odometry evolved from an “extra credit” capability into a critical vehicle safety system. In this paper we describe our Visual Odometry algorithm, discuss several driving strategies that rely on it (including Slip Checks, Keep‐out Zones, and Wheel Dragging), and summarize its results from the first 2 years of operations on Mars. © 2006 Wiley Periodicals, Inc.
Stiffness of the Roller Screw Mechanism by the Direct Method (2013)

In this paper, the direct stiffness method is used to construct a stiffness model of the roller screw mechanism. This method models the entire roller screw mechanism as a large spring system composed of individual springs representing the various compliances. In addition to predicting the overall stiffness of the mechanism, the direct stiffness method can calculate the distribution of load across the threads of the individual bodies. With the load on the individual threads known, the contact stresses can be calculated. This allows for a better understanding of the sensitivities of stiffness and contact stresses in the mechanism with various design parameters and can ultimately be used to design roller screws that are stiffer and with lower contact stresses.
Monoclonal anti-Fc epsilon receptor antibodies with different specificities and studies on the expression of Fc epsilon receptors on human B and T cells. (1986)

Three monoclonal antibodies, 1-7 (gamma 2b), 3-5 (gamma 1), and 8-30 (mu), specific to Fc epsilon receptors (Fc epsilon R) on human B cells were established. The two monoclonals (1-7 and 8-30) could inhibit the binding of IgE to Fc epsilon R in rosette formation assays, as well as FACS analysis, and were shown to recognize the same epitope of Fc epsilon R. The other monoclonal antibody (3-5) recognized the same molecule but a different epitope, and marginally inhibited the IgE binding. The molecules on RPMI 8866 cells recognized by these monoclonal antibodies had Mr of 46,000 and 25,000 to 30,000 daltons as determined by immunoprecipitation and SDS-PAGE analysis. By employing these monoclonal antibodies, the expression of Fc epsilon R on circulating lymphocytes was studied. Approximately 50% of B cells from normal, nonatopic individuals were found to express Fc epsilon R, and a remarkable increase in the expression of Fc epsilon R was observed in B cells of atopic patients. The expression of Fc epsilon R was not detected in T cells from atopic patients (including hyper IgE syndrome) as well as normal individuals. Incubation of B cells with PHA-conditioned medium plus IgE augmented the expression of Fc epsilon R in the Fc epsilon R+ B cell population but not in Fc epsilon R- population. PHA-conditioned medium plus IgE did not induce Fc epsilon R expression on T cells.
Measurement of Solute Transport Across the Blood–Brain Barrier in the Perfused Guinea Pig Brain: Method and Application to N‐Methyl‐α‐Aminoisobutyric Acid (1986)

A technique for the vascular perfusion of the guinea pig head in vivo, suitable for measurements of blood-to-brain transport under controlled conditions of arterial inflow, has been developed. With a perfusion pressure ranging between 13 and 18 kPa and PCO2 in the arterial inflow of 5 and 5.5 kPa, cerebral blood flow, measured with [14C]butanol, was about 1 ml min-1 g-1 in the cerebral cortex, hippocampus, and caudate-putamen of the ipsilateral hemisphere; in the cerebellum and pontine white matter it was considerably less, and much higher perfusion pressures were required to establish equal blood flow throughout the whole brain. Regional water content, Na+/K+ ratio, ATP, energy charge potential, and lactate content of the ipsilateral side of perfused and nonperfused brain were not significantly different after 10 min perfusion. The D-[3H]mannitol space did not exceed 1% after 30 min of perfusion, indicating the integrity of the barrier. Over this period, EEG, ECG, and respiratory waveform remained normal. When [14C]N-methyl-alpha-aminoisobutyric acid (MeAIB), and D-[3H]mannitol were perfused together over periods extending to 30 min progressive uptakes of both solutes by the parietal cortex could be measured, and the unidirectional transfer constants estimated from multiple time-uptake data. The Kin for MeAIB (0.75 X 10(-3) ml min-1 g-1) was some three times that for mannitol. It is concluded that the technique provides a stable, well-controlled environment in the cerebral microvasculature of the ipsilateral perfused brain hemisphere suitable for examining the transport of slowly penetrating solutes into the brain.
Detailed calculation of hydroxyl (OH) radical two-photon absorption via broadband ultrafast excitation (2011)

The theoretical framework for calculation of two-photon absorption cross sections for intermediate Hund’s cases (a) and (b) diatomic species is described in detail and applied toward the hydroxyl (OH) radical. Analytical expressions are derived for the 20 rotational branches that are present in the two-photon AΣ+2←XΠ2 electronic transition. Calculation of the corresponding line strengths is necessary to permit accurate relative-concentration measurements obtained from the fluorescence induced by a broadband femtosecond excitation pulse. We demonstrate, in particular, that consideration of the temperature-dependent initial-state populations of OH is necessary to obtain accurate relative concentrations from observed two-photon-excitation based laser-induced-fluorescence measurements.
Effect of Tissue-Plasminogen Activator on Leukocyte-Endothelial Interactions at the Microcirculatory Level (1998)

In free tissue transfer and replantation surgery, there is a debate over whether any pharmacologic agents should be used to improve vessel patency and tissue survival. Because tissue-plasminogen activator (t-PA) is a highly effective and safe fibrinolytic, it may be useful in obtaining and maintaining vessel patency. The direct effects of t-PA on skeletal muscle hemodynamics and leukocyte activation at the microcirculatory level were investigated. Male Sprague-Dawley rats (n = 20) were divided into three experimental groups: control (n = 8), vehicle (n = 6), and t-PA (n = 6). Using the cremaster muscle flap model and intravital microscopy, red blood cell velocity, vessel diameter, capillary perfusion, endothelial edema index, and leukocyte-endothelial interactions (rolling, adhering, and transmigrating leukocytes) in postcapillary venules were measured. In the vehicle and t-PA groups, vehicle or t-PA was infused by means of a catheter inserted into the lower abdominal aorta for local infusion. Except for a significant reduction in the diameter of the first order arterioles from 117 microm to 82 microm (medians; p = 0.026), t-PA did not significantly affect red blood cell velocity, vessel diameter, or capillary perfusion compared with vehicle. However, leukocyte-endothelial interactions did differ significantly in postcapillary venules. Adhering leukocytes counted per visual field decreased from 4.67 in the vehicle group and 3.50 in the control group to 1.67 in the t-PA group (medians; p = 0.015 and p = 0.005, respectively); transmigrating leukocytes in the t-PA group decreased from 4.75 in the vehicle group and 3.50 in the control group to 1.67 in the t-PA group (medians; p = 0.002 and p = 0.043, respectively). t-PA treatment significantly decreased the number of both adhering and transmigrating leukocytes. These novel findings on leukocyte-endothelial interactions suggest that t-PA has anti-inflammatory effect.
INTERNATIONAL COOPERATIVE TEST ON TEXTURE OF COOKED RICE (1984)

ABSTRACT i
Inhibitory effect of essential oils on apical growth of Aspergillus fumigatus by vapour contact (2000)

The inhibitory effect of seven essential oils on the apical growth of hyphae of Aspergillus fumigatus was studied using a bio cell tracer by vapour contact in a sealed vessel. Based on the inhibitory pattern, these essential oils were classified into three groups. The first group, composed of citron, lavender and tea tree oils, stopped the apical growth in a loading dose of 63 micrograms ml-1 air, but allowed the regrowth of the hyphae after removal of the vapour, indicating fungistatic action. The second group, consisting of perilla and lemon-grass oils, stopped the apical growth in a loading dose of 6.3 micrograms ml-1 air, and did not allow the regrowth after gaseous contact at 63 micrograms ml-1 air, indicative of fungicidal action. The third group, consisting of cinnamon bark and thyme oils, retarded the growth in a dose of 6.3 micrograms ml-1 air, stopped it in a dose of 63 micrograms ml-1 air, and incompletely suppressed regrowth of the hyphae. Gas chromatographic analysis revealed that vapours of essential oils were absorbed on fungal mycelia and agar medium most abundantly by the first group, followed by the second and third groups, reflecting the volatility of the respective groups. Suppression of the apical growth by vapour contact was ascribed to the direct deposition of essential oils on fungal mycelia, together with an indirect effect via the agar medium absorbed.
Elastic Deformation of Soft Tissue-Mimicking Materials Using a Single Microbubble and Acoustic Radiation Force (2020)

Mechanical effects of microbubbles on tissues are central to many emerging ultrasound applications. Here, we investigated the acoustic radiation force a microbubble exerts on tissue at clinically relevant therapeutic ultrasound parameters. Individual microbubbles administered into a wall-less hydrogel channel (diameter: 25-100 µm, Young's modulus: 2-8.7 kPa) were exposed to an acoustic pulse (centre frequency: 1 MHz, pulse length: 10 ms, peak-rarefactional pressures: 0.6-1.0 MPa). Using high-speed microscopy, each microbubble was tracked as it pushed against the hydrogel wall. We found that a single microbubble can transiently deform a soft tissue-mimicking material by several micrometres, producing tissue loading-unloading curves that were similar to those produced using other indentation-based methods. Indentation depths were linked to gel stiffness. Using a mathematical model fitted to the deformation curves, we estimated the radiation force on each bubble (typically tens of nanonewtons) and the viscosity of the gels. These results provide insight into the forces exerted on tissues during ultrasound therapy and indicate a potential source of bio-effects.
Comparative Political Economy of Long‐Term Care for Elderly People: Political Logic of Universalistic Social Care Policy Development (2011)

Abstract Despite there being common socio‐demographic pressures across advanced industrialized countries, the public elder care programmes therein tend to vary. While the current literature on social care devotes itself to describing the care arrangements of each country and pigeonholing welfare/gender regime types, it does not sufficiently address this empirical puzzle. This study looks to specify the causal relationship between political institutions and public long‐term care programmes. It argues that countries with personal‐vote‐oriented electoral systems and/or fragmented party systems have difficulties in developing universalistic public elder care programmes, whereas countries with party‐vote‐oriented electoral systems and cohesive party systems are likely to develop generous elder care programmes. For whilst the former types of political institutions prioritize patronage‐based, particularistic benefits, the latter types encourage political actors to appeal to broader constituencies through universalistic welfare programmes. This study tests this claim by examining pooled time‐series and cross‐section data of advanced democracies, from 1980 until 2001. The empirical results suggest that politicians' reliance on personal votes and the fragmentation of ruling coalitions impede the expansion of public spending for elder care.