gebhart/patrepeval huggingface dataset:
Acronyms in bone densitometry (1992)

In response to our publication (Gluer et al, 1990a), Wilson and colleagues (1990) proposed the adoption of a uniform terminology and corresponding abbreviation for Dual X-ray Absorptiometry (DXA). We supported this suggestion (Gluer et al, 1990b). Since then, the number of papers on DXA has increased considerably. Still, different abbreviations (DEXA, DER, DRA, QDR and DPX) for this technique for bone densitometry are used, several of which are proprietary in origin. DXA is the upgraded version of DPA (Dual Photon Absorptiometry). The nuclear source has been replaced by an X-ray source and this improved technology has gained wide-spread acceptance and distribution.
Conversion of a phosphoseryl/threonyl phosphatase into a phosphotyrosyl phosphatase (1988)

By use of the autophosphorylated epidermal-growth-factor receptor and the synthetic peptide RRLIE-DAEY(P)AARG, representing an autophosphorylation site of the transforming protein of Rous-sarcoma virus, it is demonstrated that the phosphotyrosyl phosphatase activity of the polycation-stimulated phosphatases is substantially increased by an enzyme-directed effect of ATP or PPi. Concomitant with this increase in phosphotyrosyl phosphatase activity, the phosphorylase phosphatase activity is decreased, thus dramatically changing the substrate specificity of these enzymes. The dephosphorylation of four different phosphotyrosyl sites of the epidermal-growth-factor receptor is neither consecutive nor at random, but a preferred dephosphorylation of the P1 site over the P3 greater than P2 greater than P4 sites is observed. This phosphatase activity represents a substantial fraction of the total phosphotyrosyl phosphatase activity in the post-mitochondrial supernatant of Xenopus laevis oocytes.
Robust clustering with applications in computer vision (1991)

A clustering algorithm based on the minimum volume ellipsoid (MVE) robust estimator is proposed. The MVE estimator identifies the least volume region containing h percent of the data points. The clustering algorithm iteratively partitions the space into clusters without prior information about their number. At each iteration, the MVE estimator is applied several times with values of h decreasing from 0.5. A cluster is hypothesized for each ellipsoid. The shapes of these clusters are compared with shapes corresponding to a known unimodal distribution by the Kolmogorov-Smirnov test. The best fitting cluster is then removed from the space, and a new iteration starts. Constrained random sampling keeps the computation low. The clustering algorithm was successfully applied to several computer vision problems formulated in the feature space paradigm: multithresholding of gray level images, analysis of the Hough space, and range image segmentation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Data from DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks (2023)

Supplementary Data from DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks
Pharmacokinetics.Selectivity of action related to physicochemical properties and kinetic patterns of anticancer drugs (1977)

Since the therapeutic index of drugs used for the treatment of cancer is small, optimal use depends on whatever advantage can be gained by achieving an effective concentration at the critical site in the cancer cell for a period of time sufficient to kill that cell while minimizing the action on normal cells or allowing their recovery. Advances in 1) methodology for measurement of minute amounts of drugs in tissues and body fluids, 2) better understanding of cell cycle kinetics and 3) development of kinetic models and computer simulation of compartmental drug distribution now aid better choice of dosage, mode of administration and treatment schedules. Limitations on the entry of amethopterin (Methotrexate) into cells and body compartments is compared with another folate antagonist, metroprine (DDMP), having the same mode of action, yet able to penetrate into brain. CSF and amethopterin-resistant cells because of greater lipid solubility. Pharmacokinetic considerations related to the limited effectiveness of present drugs for the treatment of brain tumors lead to the concept of "compartmental chemotherapy" based on selective drug contact with tumor combined with selective protection of tissues of limiting toxicity.
Genomic Structure and Characterization of the Drosophila S3 Ribosomal/DNA Repair Gene and Mutant Alleles (2000)

The Drosophila S3 protein is known to be associated with ribosomes, where it is thought to play a role in the initiation of protein translation. The S3 protein also contains a DNA repair activity, efficiently processing 8-oxoguanine residues in DNA via an N-glycosylase/apurinic-apyrimidinic (AP) lyase activity. The gene that encodes S3 has previously been localized to one of the Minute loci on chromosome 3 in Drosophila. This study focused on the genomic organization of S3 at M(3)95A, initial promoter characterization, and analysis of three mutant alleles at this locus. The S3 gene was found to be a single-copy gene 2 to 3 kb in length and containing a single intron. The upstream 1.6-kb region was analyzed for promoter activity, identifying a presumptive regulatory domain containing potential enhancer and suppressor elements. This finding is of interest, as the S3 gene is constitutively expressed throughout development and mRNA is most likely maternally inherited. Lastly, three Minute alleles from the same locus were sequenced and two alleles found to contain a 22-bp deletion in exon 2, resulting in a truncated S3 protein, although wildtype levels of S3 mRNA and protein were detected in the viable heterozygous Minute alleles, possibly reflecting dosage compensation.
Modélisation géométrique 3D du thorax par triangulation déformable : application en bioélectromagnétisme (2000)

Electro- and magneto encephalographic (EEG and MEG) as well as electro- and magneto cardio-graphic (ECG and MCG) recordings have been proved useful in non invasively extracting information on human bioelectric activity. The recovery of activity sources and location needs solving the inverse problem knowing patient anatomy. In this work, a methodology has been developed to construct patient specific boundary element models for bioelectromagnetic (BE) inverse problems from magnetic resonance (MR) data volumes as well as from 2 orthogonal X-ray projections. The complete model includes the torso, lungs and pericardium external surfaces. The process consists of three steps: reconstruction of 3-D patient geometry, triangulation, registration of the mode! with the BE data. The 3-D geometry is reconstructed by matching a 3-D deformable boundary element template to the MR data. The defom1ation results from an energy minimization process including image and model based terms. The robustness of the matching is improved by multi-resolution and global to local approaches as well as using oriented distance maps. A boundary element template is al so used when 3-D geometry is reconstructed from 2 X-ray projections. The deformation is computed in 2-D by matching the template projected contours with the real contours extracted from the data. Then the produced 2-D vector field is back-projected and interpolated on the 3-D template. A marching cube triangulation is computed from the reconstructed 3-D geometry followed by a non-iterative 3D surface mesh-simplification step. It is based on the Voronoi-Delaunay duality with discrete distance measures. Finally, the triangulated surfaces are registered with BE data utilizing markers. More than 50 boundary element models have been successfully constructed from MR images using our method. We demonstrated the feasibility of reconstructing such a mode! from 2 X-ray projections but practical problems remain to be solved before processing real data.
Exposure estimates using urban plume dispersion and traffic microsimulation models (1997)

The goal of this research effort was to demonstrate a capability for analyzing emergency response issues resulting from accidental or mediated airborne toxic releases in an urban setting. In the first year of the program, the authors linked a system of fluid dynamics, plume dispersion, and vehicle transportation models developed at Los Alamos National Laboratory to study the dispersion of a plume in an urban setting and the resulting exposures to vehicle traffic. This research is part of a larger laboratory-directed research and development project for studying the relationships between urban infrastructure elements and natural systems.
Lateral distribution of phosphatidylinositol 4,5-bisphosphate in membranes regulates formin- and ARP2/3-mediated actin nucleation (2019)

Spatial and temporal control of actin polymerization is fundamental for many cellular processes, including cell migration, division, vesicle trafficking, and response to agonists. Many actin-regulatory proteins interact with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P<sub>2</sub>) and are either activated or inactivated by local PI(4,5)P<sub>2</sub> concentrations that form transiently at the cytoplasmic face of cell membranes. The molecular mechanisms of these interactions and how the dozens of PI(4,5)P<sub>2</sub>-sensitive actin-binding proteins are selectively recruited to membrane PI(4,5)P<sub>2</sub> pools remains undefined. Using a combination of biochemical, imaging, and cell biologic studies, combined with molecular dynamics and analytical theory, we test the hypothesis that the lateral distribution of PI(4,5)P<sub>2</sub> within lipid membranes and native plasma membranes alters the capacity of PI(4,5)P<sub>2</sub> to nucleate actin assembly in brain and neutrophil extracts and show that activities of formins and the Arp2/3 complex respond to PI(4,5)P<sub>2</sub> lateral distribution. Simulations and analytical theory show that cholesterol promotes the cooperative interaction of formins with multiple PI(4,5)P<sub>2</sub> headgroups in the membrane to initiate actin nucleation. Masking PI(4,5)P<sub>2</sub> with neomycin or disrupting PI(4,5)P<sub>2</sub> domains in the plasma membrane by removing cholesterol decreases the ability of these membranes to nucleate actin assembly in cytoplasmic extracts.
Copper-Catalyzed Addition of Ethyl Diazoacetate to Furans:  An Alternative to Dirhodium(II) Tetraacetate (2005)

The complexes Tp(x)Cu (Tp(x) = homoscorpionate ligand) catalyze the high yield addition of the carbene fragment :CHCO(2)Et, from ethyl diazoacetate, to furans under mild conditions to give different cyclopropanes and dienes with ratios that depend on the Tp(x) ligand employed, therefore inducing the control of the selectivity in this transformation.
Diergezondheid op de proefboerderijen (1989)

Voor een goed vervangingsbeleid en voor het kiezen van een goed evenwicht tussen therapeutisch en preventief handelen zijn kennis over het verband tussen het voorkomen van aandoeningen en managementfactoren en inzicht in de economische gevolgen daarvan nodig.
U.S. Congress: House Weighs New Science Institute (1995)

U.S. CongressHouse Republicans have been talking about dismantling the Commerce Department, but they have been split on what to do with its various components. Last week, they finally agreed to lump Commerce's science and technology agencies into a new National Institute for Science and Technology. The plan still faces many hurdles, however, including Senate indifference and a presidential veto.
Single-channel laser Doppler vibrometers integrated on silicon-on-insulator (SOI) (2012)

Multi-location velocity measurements of a vibrating surface are of interest recently. By scanning the laser beam of a single-point laser Doppler vibrometer (LDV) across the surface of interest, one can realize the multi-location vibration measurement. However, the recovered velocity values of different locations are not obtained at the same time. In many applications, such as measuring the aortic pulse wave velocity, simultaneous velocity measurements for different locations are required. Multi-channel LDVs can be used in this case, in which multiple laser beams are generated and sent to the surface of interest simultaneously. However, the complexity of realizing the multiple interferometers in a bulk LDV system will increase as the number of channels increases, and thus it is very hard to realize a bulk LDV with many channels We propose to use the silicon-on-insulator (SOI) chip as a platform of the multi-channel interferometers. With the help of silicon photonics and CMOS technology, multiple interferometers can be miniaturized and fabricated on SOI chips. Laser beams are sent into or out of the chip through optimized on-chip grating couplers, with the coupling insertion loss of less than 2 dB per coupler. The total footprint of the integrated multiple interferometers can be very small (several square of millimetres) compared to a bulk LDV system. The cost of the chips will be dramatically decreased for mass production. Additionally, the stability of the integrated interferometers is much better than that of the interferometer built with discrete optical components.
Coronatine production in vitro and in vivo and its relation to symptom development in bacterial blight of soybean (1982)

Coronatine was detected in culture filtrates of 12 out of 19 pathogenic strains of Pseudomonas glycinea examined, but not in culture filtrates of strains of P. phaseolicola, P. syringae, or P. tabaci. A reversed-phase high-performance liquid chromatographic procedure was developed for coronatine quantitation. Generally, coronatine production by strains in culture correlated with their ability to induce systemic symptoms (chlorosis and stunting) in inoculated soybean plants. Application of purified preparations of coronatine to unifoliate leaves of soybean plants resulted in localized chlorosis, development of chlorosis in subsequently developing trifoliate leaves, and stunting of plant growth, similar to symptoms induced by infection. Coronatine was demonstrated in soybean leaves infected with P. glycinea but was not detected in healthy leaves. The results indicate that coronatine can play an important role in the development of symptoms of bacterial blight of soybean, but the demonstration that some pathogenic strains do not produce coronatine indicates that it may not be essential for pathogenicity.
Changes in the Apolar Organic Fraction Through The Composting Process (2000)

The organic fraction soluble in different organic solvents with increasing polarity was studied during the composting process, following its transformation from raw material until the stable final product with the aim to establish new quality indices of compost maturity. All apolar fractions during the composting process had a reduction higher than 50%. Part of the compounds have been utilized by the microflora as energetic material and to perform the biotransformations, and part has been transformed in molecule like the humic molecules. However, in our conditions a relevant part (36%) of apolar material is recovered at the end of the biotransformation. The spectroscopic analysis indicates in the final product an increase of lipidic compounds, as esters or acids as well as hydrocarbons with longer linear aliphatic chain.
[Efficacy of adenosine triphosphate in terminating supraventricular tachycardia]. (1993)

The efficacy of adenosine triphosphate (ATP) was tested in 23 patients suffering from supraventricular tachycardia; 10 patients had orthodromic circus movement tachycardia and 13 typical av nodal reentrant tachycardia. At a mean dose of 0.18 mg/kg all tachycardias were halted in less than 1 minute due to transient acute av nodal block followed by return to normal av conduction within 8 seconds. All patients had transient minor side effects. One elderly subject had a short episode of atrial fibrillation after the acute av block. In conclusion, ATP is useful and safe for rapid termination of supraventricular tachycardias incorporating the av node in their circuit.
Association of serum levels of antibodies against ALDOA and FH4 with transient ischemic attack and cerebral infarction (2020)

Abstract Background and Purpose: Ischemic stroke, such as Transient ischemic attack (TIA) and cerebral infarction (CI) , are the serious problems in the aging society. Therefore, development of biomarkers for TIA and CI is attempted.Methods: Candidate antigens recognized by IgG autoantibodies in the sera of nineteen TIA patients were screened by a human aortic endothelial cell cDNA library. Serum antibody levels against the antigens were examined by amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) in healthy donor (HD), TIA, and CI cohorts (n = 285, 92 and 529). A case-control study nested within the Japan Public Health Center-based Prospective Cohort Study (JPHC) was performed.Results: Aldolase A, fructose-bisphosphate (ALDOA) and fumarate hydratase (FH) were identified as the candidate antigens. AlphaLISA revealed that anti-ALDOA and anti-FH antibody levels were both higher in TIA or CI patients than in HDs ( P &lt; 0.0001). The levels of anti-ALDOA [Odds ratio (OR): 2.46, P = 0.005] and anti-FH (OR: 2.49, P = 0.0037) were independent predictors of TIA by multivariate logistic regression analysis, similar results were found in CI. The case-control study showed the levels of anti-ALDOA (OR: 2.50, P &lt; 0.01) and anti-FH (OR: 2.60, P &lt; 0.01) were associated with risk of CI. Spearman’s correlation analysis demonstrated an association between the anti-ALDOA and anti-FH levels and risk factors of ischemic stroke, such as age, smoking habit, coronary heart disease, and hypertension.Conclusions: Anti-ALDOA and anti-FH antibodies can serve as novel potential biomarkers for prediction of TIA and CI.
Stress Control in GaN Grown on 6H-SiC by Metalorganic Chemical Vapor Deposition (2011)

The strain in GaN epitaxial layers grown on 6H-SiC substrates with an AlN buffer by metalorganic chemical vapor deposition is investigated. It is found that the insertion of a graded AlGaN layer between the GaN layer and the AlN buffer can change the signs of strain. A compressive strain in an overgrown thick (2 μm) GaN layer is obtained. High-resolution x-ray diffraction, Raman spectroscopy and photoluminescence measurements are used to determine the strain state in the GaN layers. The mechanism of stress control by inserting graded AlGaN in subsequent GaN layers is discussed briefly.
Three-Phase Harmonic and Sequence Components Measurement Method Based on mSDFT and Variable Sampling Period Technique (2016)

This paper presents a three-phase harmonic and sequence components measurement method based on modulated sliding discrete Fourier transform (mSDFT) and a variable sampling period technique. The proposal allows measuring the harmonic components of a three-phase signal and computes the corresponding imbalance by estimating the instantaneous symmetrical components. In addition, an adaptive variable sampling period is used to obtain a sampling frequency multiple of the main frequency. By doing so, DFT typical errors, known as spectral leakage and picket-fence effect, are mitigated in steady state. The proposal is tested with different disturbances by simulation and experimental results. Some results obtained with a power quality monitor implemented with the proposed system are also presented. The high rejection to distortion in the electrical network, frequency adaptability, flexibility, and good performance in power quality monitor application render the proposed method a promising alternative for signal processing from the mains.
Wet Air Oxidation (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTWet Air OxidationVedprakash S. Mishra, Vijaykumar V. Mahajani, and Jyeshtharaj B. JoshiCite this: Ind. Eng. Chem. Res. 1995, 34, 1, 2–48Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/ie00040a001https://doi.org/10.1021/ie00040a001research-articleACS PublicationsRequest reuse permissionsArticle Views4208Altmetric-Citations632LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ACE inhibition in Chronic Renal Failure and in the Treatment of Diabetic Nephropathy: Focus on Spirapril (1999)

The management of hypertension and nephropathy, in both diabetes and other forms of renal disease, is usually based on blood pressure reduction through an angiotensin-converting enzyme (ACE) inhibitor-based treatment regimen. With particular respect to the choice of ACE inhibitor drug, there are no definitive direct comparisons in the treatment of renal disease. In terms of blood pressure reduction, however, there is evidence that spirapril is at least as effective as the reference ACE inhibitor, enalapril. However, patients with diabetic nephropathy and/or chronic renal failure are at potential risk from drug accumulation if the preferred agent relies predominantly on glomerular filtration for its elimination. In this respect spirapril may have an advantage because it has been shown that there are no clinically relevant increases in the spirapril(at) concentrations (24 h post-dose) even in the setting of advanced renal failure (creatinine clearance <20 ml/min). Thus, there is no requirement to modify the dose and no concerns about drug accumulation or the potential for exaggerated therapeutic or adverse effects. In summary, an ACE inhibitor drug is seen as an integral component of the drug treatment regimen for patients with nephropathy. Where there is renal failure it may be prudent to administer a drug, such as spirapril, which also has alternative elimination mechanisms.
1512: USING REAL-TIME DATA FOR ALGORITHMIC EARLY SEPSIS DETECTION IN NONCRITICAL CARE ENVIRONMENTS (2017)

Guy, Jeffrey; Jackson, Edmund; Rice, William; Harb, Anna; Mindick, Adam; Hall, Cody; Tobias, Martin; Gregg, William; Chari, Ravi; Perlin, Jonathan Author Information
Gloucester ruby project -- an update (2001)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
A Comparison of Electronystagmography Results with Posturography Findings from the BalanceTrak 500 (2002)

For many patients with dizziness and/or balance dysfunctions, posturography can provide additional information to that obtained with electronystagmography. This is especially apparent in individuals who have these symptoms but have normal or borderline normal electronystagmography findings.