gebhart/patrepeval huggingface dataset:
Oxidation-Reduction Potential-Dependent Adenosine Triphosphatase Activity of Chromatophores from Rhodospirillum rubrum (1968)

Journal Article Oxidation-Reduction Potential-Dependent Adenosine Triphosphatase Activity of Chromatophores from Rhodospirillum rubrum Get access YOSIFUMI HORIUTI, YOSIFUMI HORIUTI From the Division of Enzymology, Institute for Protein Research, Osaka UniversityKita-ku, Osaka Search for other works by this author on: Oxford Academic PubMed Google Scholar KATSUZO NISHIKAWA, KATSUZO NISHIKAWA From the Division of Enzymology, Institute for Protein Research, Osaka UniversityKita-ku, Osaka Search for other works by this author on: Oxford Academic PubMed Google Scholar TAKEKAZU HORIO TAKEKAZU HORIO From the Division of Enzymology, Institute for Protein Research, Osaka UniversityKita-ku, Osaka Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 64, Issue 5, November 1968, Pages 577–587, https://doi.org/10.1093/oxfordjournals.jbchem.a128934 Published: 01 November 1968 Article history Received: 27 March 1968 Published: 01 November 1968
Deep Learning Assisted Calibrated Beam Training for Millimeter-Wave Communication Systems (2021)

Huge overhead of beam training imposes a significant challenge in millimeter-wave (mmWave) wireless communications. To address this issue, in this paper, we propose a wide beam based training approach to calibrate the narrow beam direction according to the channel power leakage. To handle the complex nonlinear properties of the channel power leakage, deep learning is utilized to predict the optimal narrow beam directly. Specifically, three deep learning assisted calibrated beam training schemes are proposed. The first scheme adopts convolution neural network to implement the prediction based on the instantaneous received signals of wide beam training. We also perform the additional narrow beam training based on the predicted probabilities for further beam direction calibrations. However, the first scheme only depends on one wide beam training, which lacks the robustness to noise. To tackle this problem, the second scheme adopts long-short term memory (LSTM) network for tracking the movement of users and calibrating the beam direction according to the received signals of prior beam training, in order to enhance the robustness to noise. To further reduce the overhead of wide beam training, our third scheme, an adaptive beam training strategy, selects partial wide beams to be trained based on the prior received signals. Two criteria, namely, optimal neighboring criterion and maximum probability criterion, are designed for the selection. Furthermore, to handle mobile scenarios, auxiliary LSTM is introduced to calibrate the directions of the selected wide beams more precisely. Simulation results demonstrate that our proposed schemes achieve significantly higher beamforming gain with smaller beam training overhead compared with the conventional and existing deep-learning based counterparts.
Sequence of the Gene Encoding the Major Neutralization Antigen (VP7) of Serotype 10 Rotavirus (1991)

The sequence of the gene encoding the major neutralization antigen (VP7) of the type member (bovine virus strain B223) of the proposed serotype 10 of rotavirus has been determined. This was done using a rapid new strategy involving direct sequencing by primer extension of cDNA generated from the relevant virus gene (gene 8) using a combined reverse transcription/polymerase chain reaction. The sequence obtained is 1062 bp in length and contains a single long open reading frame capable of encoding a protein of 326 amino acids. Comparison of the sequence to that of the corresponding gene of the other major virus serotype found in cattle, serotype 6, showed that it was approximately 25% divergent at the nucleotide level and 18% divergent at the amino acid level.
Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning (2019)

A varying oxygen environment is known to affect cellular function in disease as well as activity of various therapeutics. For transient structures, whether they are unconstrained therapeutic transplants, migrating cells during tumor metastasis, or cell populations induced by an immunological response, the role of oxygen in their fate and function is known to be pivotal albeit not well understood in vivo. To address such a challenge in the case of generation of a bioartificial pancreas, we have combined fluorine magnetic resonance imaging and unsupervised machine learning to monitor over time the spatial arrangement and the oxygen content of implants encapsulating pancreatic islets that are unconstrained in the intraperitoneal (IP) space of healthy and diabetic mice. Statistically significant trends in the postimplantation temporal dependence of oxygen content between aggregates of 0.5-mm or 1.5-mm alginate microcapsules were identified in vivo by looking at their dispersity as well as arrangement in clusters of different size and estimating oxygen content on a pixel-by-pixel basis from thousands of 2D images. Ultimately, we found that this dependence is stronger for decreased implant capsule size consistent with their tendency to also induce a larger immunological response. Beyond the bioartificial pancreas, this work provides a framework for the simultaneous spatiotemporal tracking and oxygen sensing of other cell populations and biomaterials that change over time to better understand and improve therapeutic design across diverse applications such as cellular transplant therapy, treatments preventing metastatic formation, and modulators for improving immunologic response, for all of which oxygen is a major mechanistic component.
Simultaneous characterization of progenitor cell compartments in adult human liver (2009)

The human liver is a complex tissue consisting of epithelial, endothelial, hematopoietic, and mesenchymal elements that probably derive from multiple lineage-committed progenitors, but no comprehensive study aimed at identifying and characterizing intrahepatic precursors has yet been published. Cell suspensions for this study were obtained by enzymatic digestion of liver specimens taken from 20 patients with chronic liver disease and 13 multiorgan donors. Stem and progenitor cells were first isolated, amplified, and characterized ex vivo according to previously validated methods, and then optimized flow cytometry was used to assess their relative frequencies and characterize their immunophenotypes in the clinical specimens. Stem and progenitor cells committed to hematopoietic, endothelial, epithelial, and mesenchymal lineages were clearly identifiable in livers from both healthy and diseased subjects. Within the mononuclear liver cell compartment, epithelial progenitors [epithelial cell adhesion molecule (EpCAM)(+)/CD49f(+)/CD29(+)/CD45(-)] accounted for 2.7-3.5% whereas hematopoietic (CD34(+)/CD45(+)), endothelial [vascular endothelial growth factor-2 (KDR)(+)/CD146(+)/CD45(-)], and mesenchymal [CD73(+)/CD105(+)/CD90 (Thy-1)(+)/CD45 (-)] stem cells and progenitors accounted for smaller fractions (0.02-0.6%). The patients' livers had higher percentages of hematopoietic and endothelial precursors than those of the donors. In conclusion, we identified and characterized precursors committed to four different lineages in adult human liver. We also optimized a flow cytometry approach that will be useful in exploring the contribution of these cells to the pathogenesis of liver disease.
Changes in Cardiovascular Health Across Midlife and Late-Life and Magnetic Resonance Imaging Markers of Cerebral Vascular Disease in Late-Life (2023)

Improving cardiovascular health within midlife and from midlife to late-life may prevent development of cerebral vascular disease.
Effect of redox potential and OCP in ferric and cupric chloride leaching of gold (2020)

The research presented contributes to the global goal of responsible production by providing robust tools for the optimization of gold dissolution in cyanide-free gold leaching solutions, which represent emerging non-toxic gold technologies. In the current study, gold dissolution was investigated in ferric and cupric chloride solutions. The effect of the redox potential on the open circuit potential (OCP) and dissolution rate of gold was investigated experimentally in the parameter range of T = 25–95 °C, [Fe3+/Cu2+] = 0.02–1.0 M, [Cl−] = 1–5 M, pH = 0.0–2.0, and ωcyc = 2500 RPM. A high rotational speed was chosen to minimize the effects of limited mass transfer rate. The aim was to provide tools for estimating the gold dissolution rate in ferric and cupric chloride solutions, using the solution properties. The results showed that redox potentials, OCPs, and dissolution rates were constantly higher in ferric chloride solutions compared to corresponding cupric chloride solutions. The multilinear regression models for redox potential showed that a rise in temperature and oxidant concentration increased the redox potential in both ferric and cupric chloride solutions. However, an increase in the chloride concentration decreased the redox potential in ferric chloride solutions, whereas the effect was the opposite in cupric solutions. A rise in the pH value increased the redox potential in ferric solutions, but this was found to be an insignificant variable in cupric chloride leaching within the investigated parameter range. The redox potential had a positive correlation with OCP and the logarithm of the gold dissolution rate in both investigated systems. The results suggest that, in the chloride leaching systems examined, the solution properties can be used to determine the redox potential, and furthermore, the redox potential can be used to estimate the gold dissolution rate. This study provides an experimentally verified tool for the robust estimation of the gold dissolution rate in chloride systems.
Non-Invasive Treatments for Failed Back Surgery Syndrome: A Systematic Review (2022)

Our systematic review highlights the efficacy of conservative treatments in FBSS patients, with an improvement in pain scores and a decrease in disability index, especially after SCS with HFS. However, due to the lack of homogeneity among trials and population characteristics, further studies are needed to confirm the effectiveness of non-invasive interventions in patients affected by FBSS.
Abstract 1643: Discovery of 1-benzylquinazoline-2,4(1H,3H)-diones as novel and potent PARP inhibitors. SAR of the benzyl group (2015)

Abstract Poly (ADP-ribose) polymerase (PARP) is a key enzyme for DNA repair and PARP-1 inhibitors have been shown to be effective against cancers with DNA repair defects, such as BRCA1 or BRCA2 mutations. Recently, European Medicines Agency (EMA) recommended approval of PARP-1 inhibitor Olaparib (AZD2281) for the treatment of ovarian cancers with BRCA mutations. In this presentation, we will report our discovery of a series of 1-benzylquinazoline-2,4(1H,3H)-diones (BQD) as novel and potent PARP inhibitors. We will present SAR data for substituents at the 3- and 4-positions of the benzyl group of BQD, and the identification of IMP4297 as a clinical candidate. IMP4297 has advantages in vitro and in vivo over AZD2281. It is not only more potent but also more selective than AZD2281 in cell-based assays, and was 20-fold more efficacious than AZD2281 in a BRCA1 mutated MDA-MB-436 human breast cancer xenograft model. IND enabling studies for IMP4297 is in progress with IND submission planned in 12 months. Citation Format: Sui Xiong Cai, Qingbing Xu, Lizhen Wu, Feng Yin, Xiuhua Hu, Xiaozhu Wang, Yangzhen Jiang, Qingli Bao, Guoxiang Wang, Xiuyan Zhang, Ye Edward Tian. Discovery of 1-benzylquinazoline-2,4(1H,3H)-diones as novel and potent PARP inhibitors. SAR of the benzyl group. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1643. doi:10.1158/1538-7445.AM2015-1643
Supplementary Data S1 from <i>NPY</i> Methylated ctDNA is a Promising Biomarker for Treatment Response Monitoring in Metastatic Colorectal Cancer (2023)

&lt;p&gt;Supplementary data on the comparison of anti-EGFR therapy to anti-VEGF therapy.&lt;/p&gt;
Effects of subresolution assist features on depth of focus and uniformity of contact windows for 193-nm lithography (1999)

Sub-resolution assist features can significantly improve depth of focus and uniformity of critical dimensions of contact windows especially when combined with appropriately optimized conditions. In this paper, the placement and dimension control of assist features for 160nm contact windows are studied and analyzed using 193 nm lithography in conjunction with state-of-the-art single layer resist. Our study is based on comparison of simulation and experimental data obtained form critical dimension measurements with varying exposure dose, focus, and in different environments. Computer simulations are performed using such commercial lithography software tools as Prolith and Solid-C. Along with optical proximity corrections, we use different conventional and off-axis illumination conditions which increases depth of focus of contact windows and improves the overall process latitude. A test photomask with different configurations of contact windows with and without assist features has been specifically designed for this study. The results have shown that when used with appropriate illumination conditions, especially quadrupole off-axis, sub-resolution assist features increase the depth of focus of contact windows by about 0.3 micrometers , significantly decrease the proximity effects, and improve the overall process latitude.
The Use of Device‐Based Diagnostics to Manage Patients With Heart Failure (2008)

Heart failure patients continue to increase in number and complexity with a growing need for better management strategies. With a significant number of these patients also having implantable devices, the opportunity to treat patients utilizing the information stored in the devices is tremendous. The data available include arrhythmias, heart rates, activity levels, and new heart failure monitoring markers. Additional metrics are in development and may provide improved monitoring and treatment capabilities. Information can be accessed in a number of ways, with increasing availability either in the office or remotely. Learning how to access and utilize these data will benefit patients currently and allow the incorporation of the significant amounts of data that are currently in development.
Transient blockade of chemokine receptors (CCR2, CCR5) does not prevent type 1 diabetes in prediabetic NOD-mice (2005)

Background Migration of proinflammatory lymphocytes into the islets of Langerhans during pathogenesis of type 1 diabetes depends on expression of certain chemokines and their receptors. It was the aim of this study to determine if the blockade of the chemokine receptors CCR5 or CCR2 can prevent the late invasion of destructive lymphocytes into the islets in prediabetic female NOD-mice and thus prevent diabetes.
Effective Oxidation of Sulfides to Sulfoxides with Hydrogen Peroxide under Transition-Metal-Free Conditions (2007)

A "green" highly selective oxidation of organic sulfides to the corresponding sulfoxides was developed using hydrogen peroxide and glacial acetic acid under transition metal-free and mild conditions. The oxidation procedure is very simple and the products are easily isolated in excellent yields (90-99%).
Permanent Abandonment of a North Sea Well Using Unconsolidated Well-Plugging Material (2011)

Summary The traditional plug-and-abandonment (P&amp;A) method of exploration wells in the North Sea is to set a series of cement plugs to isolate the pressurized zones from each other and from surface. This paper describes a North Sea P&amp;A field case. In this case, an alternative method was used with a Bingham-plastic unconsolidated plugging material with high solids concentrations. This alternative method addresses well-integrity issues such as those caused by shrinking of cement or gas migration during setting, fracturing after setting, or long-term degradation by exposure to heat and chemical substances in the well. The gas-tight well-barrier element described here does not set up after placement and does not shrink. Furthermore, it cannot fracture even when shear forces exceed its strength. When this happens, the material floats and shear forces are reduced below yield strength, causing the plug to reshape. Because this is a purely mechanical process, the transition between solid and fluid phase is repeatedly reversible (in principle, an infinite number of times). The plug is thermodynamically stable because its sealing property is decided by the solids particle-size distribution (PSD) and bound water only. The closely packed particles and absence of free water mean that the entire column is kept homogeneous and no internal redistribution of particles may occur. Hence, the permanent gas-tight barrier will prevent influx through the wellbore. In the field case, a successful implementation of the technology was obtained. The field case shows how the fast and efficient placement of the plug contributes to overall cost reduction. The paper explains how the well-barrier element complies with Norwegian requirements for permanent P&amp;A; these requirements also apply to the UK sector (NORSOK D-010 2004; Oil and Gas UK 2009). Operational procedures are also presented in some detail.
Measurement, modelling, and control of the reactive species composition in the effluent of an argon plasma jet (2012)

Summary form only given. Only with the recent development of cold atmospheric pressure plasma sources plasmas are broadly studied for application in therapeutic medicine. These plasma sources generate highly reactive plasma components in ambient conditions and their gas temperature is below the destruction threshold of extremely sensitive surfaces such as biomaterials [1].
A comparative study of TV and Internet advertising in the context of emotions parameter (2014)

The field of advertising has been on a constant uptick since it came into being. While the advent of Television gave advertising a massive push, the next big thing, the Internet, gave rise to Internet advertising. However a debate has raged on for quite a while now as to the efficacy and effectiveness of advertising in the different media like print, radio, TV, Internet, outdoor etc. With the coming of Internet, people started comparing its effectiveness in the context of advertising vis-a-vis other traditional media, most notably TV. Since then, studies have taken place to ascertain the superiority of one medium over the other. However, the results have been conflicting.
Dietary selenium intakes and their association with muscle strength and function in ≥ 85 year old adults: the Newcastle 85 + Study (2020)

Abstract Selenium is an essential micronutrient with biochemical and cellular effects through activities of 25 selenocysteine-containing selenoproteins. Selenoproteins are anti-inflammatory and have antioxidant properties. Severe selenium deficiency causes muscle weakness and atrophy in humans however the effects of moderate selenium deficiency are unclear. The aims of this study are twofold: 1) to determine dietary selenium intakes and contributing food sources in very old adults and; 2) to determine whether dietary selenium intakes are associated with 5-year trajectories of muscle function: hand-grip strength (HGS) and Timed-Up-and-Go (TUG). Cross-sectional (baseline) and prospective (1.5, 3 and 5-year follow-up) analyses of 845 participants aged 85 years from the Newcastle 85 + study were assessed for HGS and TUG performance using standardized protocols (Antoneta et al. 2016). Baseline dietary intakes were assessed using 24-hour multiple pass recall methods on two separate days (Mendonça et al. 2016). The top selenium food contributors (~90%) and the adequacy of intakes were determined i.e. those with intakes &lt; LRNI, between the LRNI and RNI and &gt; RNI. Linear mixed models explored the associations between selenium intake categories and time on the prospective, 5-year change in HGS and TUG in all participants, males and females. Median intakes of selenium were 39, 48 and 35μg for all participants, males and females, respectively. Selenium intakes were below the LRNI in 51% of participants (median 27μg) whilst 15% had intakes ≥ the RNI (median 85μg). Only 13.3% of females and 16.9 % of males met the RNI. The top selenium contributors were cereals (46%), meat (22%), fish (10%), milk (6%), eggs (4%) and potatoes (3%) making up 91% of selenium intakes. Those with the lowest intakes had 2.72 kg lower HGS and 2.36s slower TUG compared to those with higher intakes (P &lt; 0.005). There was no association between selenium intake in HGS or TUG, but time had a significant effect on the rate of change over 5-years in both parameters (P &lt; 0.001). Overall these results show that poor dietary selenium intakes are common in very old adults and that cereal and cereal products are major sources of selenium in this population. Whilst low selenium intakes are associated with worse HGS and TUG performance in the cross-sectional analysis, no significant associations were observed in the prospective analyses.
Discovering Fuzzy Periodic-Frequent Patterns in Quantitative Temporal Databases (2020)

Periodic-frequent pattern mining is a challenging problem of great importance in many applications. Most previous works focused on finding these patterns in binary temporal databases and did not take into account the quantities of items within the data. This paper proposes a novel model of fuzzy periodic-frequent pattern (FPFP) that may exist in a quantitative temporal database (QTD). Finding FPFPs in QTD is a non-trivial and challenging task due to its huge search space. A novel pruning technique, called improved maximum scalar cardinality, has been introduced to effectively reduce the search space and the computational cost of finding the desired itemsets. This technique facilitates the mining of FPFPs in real-world very large databases practicable. An efficient algorithm has also been presented to find all FPFPs in a QTD. Experimental results demonstrate that the proposed algorithm is efficient. We also present a case study in which we apply our model to find useful information in air pollution database.
Interpretation of line drawings with multiple views (2002)

A method for interpreting engineering drawings with multiple orthogonal views is presented. The number of views required is not fixed and can range from a minimum of two to a maximum of six using a standard drawing layout. The method call handle input views with small errors or inaccuracies and still produce a valid interpretation. The solution is based on a bottom-up approach in which candidate vertices and edges are used to generate a set of possible faces which are in turn assembled into enclosures representing the final object. All possible interpretations consistent with the input views are found, and inconsistent input views are recognized by the fact that no possible consistent interpretation can be obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Non-Destructive Depth Profile Analysis of Conversion in Thick-Layer UV Curable Resin Using Laser Micro-Raman Spectrometer (2007)

厚膜塗布された紫外（UV）硬化樹脂硬化物内部の硬化反応率の深さ方向分布（デプスプロファイル）を顕微レーザーラマン分光装置を用いて非破壊にて解析する手法を検討した．UV硬化樹脂の硬化状態のデプスプロファイリング法は，厚膜（1∼数mm）塗布されたものに対応するものが数少なく，特に非破壊の方法が見当たらなかった．一方，顕微レーザーラマン分光法は厚膜フィルム材料の非破壊内部解析に適しているが，UV硬化樹脂に適用しようとすると，強力な励起レーザー光によって試料の光硬化反応が進行して正しい測定ができないという懸念があった．また，試料の光硬化反応が少ない長波長レーザーを使用する場合には，ラマン光が微弱であるために深部の情報が得られず，厚膜UV硬化樹脂には適用できない可能性もあった．本研究では，ウレタンメタクリレート系UV硬化樹脂を試料として，まず，励起レーザー波長に比較的長い780 nmを使用し，UV硬化樹脂に216秒間の照射をしても光硬化反応が進行しないことを確認した．次に厚さ1.86 mmの硬化物内部に60秒間の励起レーザー照射をしてラマンスペクトルを深さごとに得て，最深部のデータも明瞭に得られることを確認した．これらのスペクトルに呈するメタクリル基のC=C伸縮振動（1635 cm-1）のピーク面積から試料の各深さにおける硬化反応率を計算し，デプスプロファイルを求めた．本研究により，顕微レーザーラマン分光装置を用いて厚膜UV硬化樹脂の硬化反応率デプスプロファイルを非破壊で解析することが可能であることが明らかになった．