gebhart/patrepeval huggingface dataset:
Dopamine Receptors Modulate Cytotoxicity of Natural Killer Cells via cAMP-PKA-CREB Signaling Pathway (2013)

Dopamine (DA), a neurotransmitter in the nervous system, has been shown to modulate immune function. We have previously reported that five subtypes of DA receptors, including D1R, D2R, D3R, D4R and D5R, are expressed in T lymphocytes and they are involved in regulation of T cells. However, roles of these DA receptor subtypes and their coupled signal-transduction pathway in modulation of natural killer (NK) cells still remain to be clarified. The spleen of mice was harvested and NK cells were isolated and purified by negative selection using magnetic activated cell sorting. After NK cells were incubated with various drugs for 4 h, flow cytometry measured cytotoxicity of NK cells against YAC-1 lymphoma cells. NK cells expressed the five subtypes of DA receptors at mRNA and protein levels. Activation of D1-like receptors (including D1R and D5R) with agonist SKF38393 enhanced NK cell cytotoxicity, but activation of D2-like receptors (including D2R, D3R and D4R) with agonist quinpirole attenuated NK cells. Simultaneously, SKF38393 elevated D1R and D5R expression, cAMP content, and phosphorylated cAMP-response element-binding (CREB) level in NK cells, while quinpirole reduced D3R and D4R expression, cAMP content, and phosphorylated CREB level in NK cells. These effects of SKF38393 were blocked by SCH23390, an antagonist of D1-like receptors, and quinpirole effects were abolished by haloperidol, an antagonist of D2-like receptors. In support these results, H89, an inhibitor of phosphokinase A (PKA), prevented the SKF38393-dependent enhancement of NK cells and forskolin, an activator of adenylyl cyclase (AC), counteracted the quinpirole-dependent suppression of NK cells. These findings show that DA receptor subtypes are involved in modulation of NK cells and suggest that D1-like receptors facilitate NK cells by stimulating D1R/D5R-cAMP-PKA-CREB signaling pathway and D2-like receptors suppress NK cells by inhibiting D3R/D4R-cAMP-PKA-CREB signaling pathway. The results may provide more targets of therapeutic strategy for neuroimmune diseases.
Miniaturized implantable patch antenna for near-field communication at ISM band (2017)

We present an implantable patch antenna designed for near-field communication with an external repeater device. The geometry is composed of a X-slot and four T-slots that increase the electric-length, thus miniaturizing the antenna, achieving a diameter of just 8 mm (0.064λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ) for an antenna operation at 2.4 GHz. Moreover, the input reflection coefficient exhibits robust performance for different implantation depths. Lastly, we calculate a maximum input power imposed by Specific Absorption Rate regulation, according to Federal Communications Commission (FCC) and International Commission on Non-Ionizing Radiation Protection (ICNIRP).
Mixed Finite Element Methods on Nonmatching Multiblock Grids (2000)

We consider mixed finite element methods for second order elliptic equations on nonmatching multiblock grids. A mortar finite element space is introduced on the nonmatching interfaces. We approximate in this mortar space the trace of the solution, and we impose weakly a continuity of flux condition. A standard mixed finite element method is used within the blocks. Optimal order convergence is shown for both the solution and its flux. Moreover, at certain discrete points, superconvergence is obtained for the solution and also for the flux in special cases. Computational results using an efficient parallel domain decomposition algorithm are presented in confirmation of the theory.
Supplying high availability with a standard network file system (2003)

The design of a network file service that is tolerant to fail-stop failures and that can be run on top of a standard network file service is described. The fault-tolerance is completely transparent, so the resulting file system supports the same set of heterogeneous workstations and applications as the chosen standard, To demonstrate that the design can provide the benefit of highly available files at a reasonable cost to the user, a prototype has been implemented using the Sun NFS protocol. The approach is not limited to being used with NFS and should apply to any network file service built along the client-server model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A joint trajectory generator for motion recovery (2003)

This paper describes an adaptive S-curve used to recover a tool path upon a system crash in the Windows operating system (OS). For a mechanism such as a robot or machine tool, the joint values, being delivered as setpoints to the servo-controller, are dynamically recorded by the real-time operating system also residing on the computer. The real-time OS can control the abort and record pertinent motion data after Windows OS crash. Upon system recovery, the recovery trajectory generator examines the setpoints intervals to determine the current slow joint . At every trajectory step, and for the current slow joint, the S-curve velocity profile applies the joint entry state (position, speed, acceleration, and jerk) to interpolate the motion between the setpoints in a reverse direction. The other joints are proportionally interpolated (slowed) so that they pass through each setpoint simultaneously with the slow joint, but in a reverse direction. The trajectory algorithm is optimal since the slow joint always uses the maximum allowable jerk to change the profile speed and acceleration for each trajectory step.
Intrinsic Temperature Compensation of Interferometric and Polarimetric Fiber-Optic Current Sensors (2014)

We theoretically and experimentally demonstrate a method to achieve insensitivity to temperature to within &lt;±0.1% from −40 to 85°C for fiber-optic current sensors with dynamic and static phase biasing and different types of sensing fiber.
A Practical, Systematic Approach for the Scaling‐Up and Modeling of Industrial Copolymerization Reactors (2003)

A systematic methodology for the modeling and engineering analysis of industrial copolymerization reactors is presented. The methodology, especially suited for the scaling‐up from laboratory experiments to pilot plant and industrial reactor level, consists of gradually building models of more complexity in a modular way as more information is obtained from experimental data and/or theoretical considerations. In the first stage, simple models for copolymer composition are written based on the Mayo–Lewis copolymerization equation and empirical copolymerization rate data for different reactor configurations (batch and CSTR) and reactor operations (steady state and some dynamic transients for the CSTR case). This set of models, which use minimal or no data fitting, is shown to be highly predictive. In a second stage, as kinetic information is obtained in the form of an expression for the copolymerization rate, either empirical or mechanistic, the models can be gradually expanded to include a full non‐linear analysis of steady state multiplicities and other interesting phenomena, which can have an impact on the practical operation of the reactor. Also, as a complementary tool for the modeling of copolymerization reactors, a new model for the gel effect in polymerization, based on analogies with the familiar diffusion controlled reactions in heterogeneous catalytic reactors, is outlined and used. The methodology is illustrated with examples drawn from industrial reactors in bulk and emulsion, including some industrial reactor data.
Syntheses of substituted imidazo[1,2-a]pyridines via "ylide-like" intermediates (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses of substituted imidazo[1,2-a]pyridines via "ylide-like" intermediatesWilliam W. Paudler and Hyun G. ShinCite this: J. Org. Chem. 1968, 33, 4, 1638–1639Publication Date (Print):April 1, 1968Publication History Published online1 May 2002Published inissue 1 April 1968https://pubs.acs.org/doi/10.1021/jo01268a071https://doi.org/10.1021/jo01268a071research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ultrathin FeOOH Nanolayers with Abundant Oxygen Vacancies on BiVO4 Photoanodes for Efficient Water Oxidation (2018)

Photoelectrochemical (PEC) water splitting is a promising method for storing solar energy in the form of hydrogen fuel, but it is greatly hindered by the sluggish kinetics of the oxygen evolution reaction (OER). Herein, a facile solution impregnation method is developed for growing ultrathin (2 nm) highly crystalline β-FeOOH nanolayers with abundant oxygen vacancies on BiVO<sub>4</sub> photoanodes. These exhibited a remarkable photocurrent density of 4.3 mA cm<sup>-2</sup> at 1.23 V (vs. reversible hydrogen electrode (RHE), AM 1.5 G), which is approximately two times higher than that of amorphous FeOOH fabricated by electrodeposition. Systematic studies reveal that the excellent PEC activity should be attributed to their ultrathin crystalline structure and abundant oxygen vacancies, which could effectively facilitate the hole transport/trapping and provide more active sites for water oxidation.
Hospital encounters and associated costs of prostate evaluation for clinically important disease (2023)

Patients in the TRUS biopsy group experienced more hospital encounters compared to patients who received an MRI prior to their biopsy. This economic analysis suggests that MRI imaging prior to biopsy is not associated with a significant increase in costs.
An Adaptive VM Provisioning Method for Large-Scale Agent-Based Traffic Simulations on the Cloud (2014)

Using the Cloud for large-scale distributed simulations, such as agent-based traffic simulations, sounds like a good idea, as it is possible to provision and release easily processing nodes (e.g., Virtual machines) in the Cloud. However, the question is complex as it involves users' objectives, such as, time to process the simulation and cost of the simulation, and because the workload evolves in distributed simulations, in each node and the whole system, and this impact the resource provisioning plans. This paper proposes two main contributions: (i) a method for efficient utilization of computational resources for distributed agent-based simulations, providing a mechanism that adapts the resource provisioning to users' objectives and workload evolution, and (ii) a staged asynchronous migration technique to limit the migration overhead when the number of workers change. Our preliminary experimental results on a 24 hour scenario of traffic in the city of Tokyo show that our system outperforms a static provisioning by 12% in average and 23% during periods when workload changes a lot.
Using a morphological analyzer in high precision POS tagging of Hungarian (2006)

The paper presents an evaluation of maxent POS disambiguation systems that incorporate an open source morphological analyzer to constrain the probabilistic models. The experiments show that the best proposed architecture, which is the first application of the maximum entropy framework in a Hungarian NLP task, outperforms comparable state of the art tagging methods and is able to handle out of vocabulary items robustly, allowing for efficient analysis of large (web-based) corpora. 1.
Increasing Selective CO2 Adsorption on Amine-Grafted SBA-15 by Increasing Silanol Density (2011)

Two template removal methods were employed to create porosity in mesoporous silica SBA-15: ethanol extraction versus conventional high-temperature calcination. The resulting silicas were subjected to amine (3-aminopropyl) grafting and studied for their CO2 adsorption properties. The goal was to significantly increase the surface silanol density, and hence the grafted amine loading, leading directly to increased CO2 adsorption capacity and CO2/N2 selectivity. Thus, the silanol density was increased from 3.4 OH/nm2 for the calcined SBA-15 to 8.5 OH/nm2 for the SBA-15 by solvent extraction. Correspondingly, for these two samples, the grafted amine loading was increased from 2.2 to 3.2 mmol/g, and the CO2 adsorption capacity was increased from 1.05 to 1.6 mmol/g at conditions relevant to CO2 capture (0.15 bar and 25 °C), or a 52% increase. The CO2/N2 selectivity was increased from 46 to 131. The isosteric heats of adsorption, the sorbent stability during cyclic adsorption–desorption, and the (positive) effects of moisture on CO2 adsorption were also investigated and compared.
Effects of canola, corn, and olive oils on fasting and postprandial plasma lipoproteins in humans as part of a National Cholesterol Education Program Step 2 diet. (1993)

The most stringent dietary recommendations of the National Cholesterol Education Program (NCEP) are to limit fat intake to &lt; 30% of calories, saturated fat intake to &lt; 7% of calories, and cholesterol intake to &lt; 200 mg/d (Step 2 diet). There is debate as to whether the remaining fat in the diet should be relatively high in monounsaturated or polyunsaturated fatty acids. We examined this issue by testing the effects of diets meeting the aforementioned guidelines that were enriched in three different vegetable oils on plasma lipids in the fasting and postprandial states in a clinically relevant population. Female and male subjects (n = 15, mean age, 61 years) with low-density lipoprotein cholesterol (LDL-C) concentrations &gt; 130 mg/dL were studied under strictly controlled conditions. Subjects were first placed on a diet similar to that currently consumed in the United States to stabilize plasma lipids with respect to identical fat and cholesterol intakes. The subjects then received diets meeting NCEP Step 2 criteria in which two thirds of the fat calories were given either as canola, corn, or olive oil in a randomized, double-blinded fashion for 32 days each. Plasma cholesterol concentrations declined after consumption of diets enriched in all the test oils; however, the declines were significantly greater for the canola (12%) and corn (13%) than for the olive (7%) oil-enriched diet. Mean plasma LDL-C concentrations declined after consumption of diets enriched in all the test oils (16%, 17%, and 13% for canola, corn, and olive oil, respectively), and the magnitude of the declines was statistically indistinguishable among the test oils. Mean plasma high-density lipoprotein cholesterol (HDL-C) concentrations declined after consumption of the baseline diet, and these declines were significant for the canola (7%) and corn (9%) oil-enriched diets. Changes in LDL apolipoprotein (apo)B concentrations paralleled those of LDL-C. Switching from the baseline to the vegetable oil--enriched diets had no significant effect on plasma triglyceride, apoA-I, and lipoprotein(a) concentrations or the total cholesterol to HDL-C ratio. LDL apoB to apoA-I ratios were significantly reduced when the subjects consumed the vegetable oil--enriched diets. Differences similar to those observed in the fasting state were observed in the postprandial state.(ABSTRACT TRUNCATED AT 400 WORDS)
On hard decision upper bounds for coded M-ary hierarchical modulation (2011)

Hierarchical modulation is used in conjunction with error correction coding in many multimedia communication systems to provide unequal protection. We show that hard decision upper bounds given for binary symmetric channels can be used to find upper bounds for the bit error rate of different bit classes of a coded M-ary hierarchical modulation.
Randomized Controlled Trial of Calcitriol in Severe Sepsis (2014)

Calcitriol administration did not increase plasma cathelicidin protein levels in critically ill patients with sepsis and had mixed effects on other immunomodulatory markers. Additional phase II trials investigating the dose and timing of calcitriol as a therapeutic agent in specific sepsis phenotypes may be warranted. Clinical trial registered with www.clinicaltrials.gov (NCT 01689441).
Nearly insensitive bounds on SMART scheduling (2005)

We define the class of SMART scheduling policies. These are policies that bias towards jobs with small remaining service times, jobs with small original sizes, or both, with the motivation of minimizing mean response time and/or mean slowdown. Examples of SMART policies include PSJF, SRPT, and hybrid policies such as RS (which biases according to the product of the remaining size and the original size of a job).For many policies in the SMART class, the mean response time and mean slowdown are not known or have complex representations involving multiple nested integrals, making evaluation difficult. In this work, we prove three main results. First, for all policies in the SMART class, we prove simple upper and lower bounds on mean response time. Second, we show that all policies in the SMART class, surprisingly, have very similar mean response times. Third, we show that the response times of SMART policies are largely insensitive to the variability of the job size distribution. In particular, we focus on the SRPT and PSJF policies and prove insensitive bounds in these cases.
STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8 (2021)

Intestinal homeostasis and the maintenance of the intestinal epithelial barrier are essential components of host defense during gastrointestinal Salmonella Typhimurium infection. Both require a strict regulation of cell death. However, the molecular pathways regulating epithelial cell death have not been completely understood. Here, we elucidated the contribution of central mechanisms of regulated cell death and upstream regulatory components during gastrointestinal infection. Mice lacking Caspase-8 in the intestinal epithelium are highly sensitive towards bacterial induced enteritis and intestinal inflammation, resulting in an enhanced lethality of these mice. This phenotype was associated with an increased STAT1 activation during Salmonella infection. Cell death, barrier breakdown and systemic infection were abrogated by an additional deletion of STAT1 in Casp8<sup>ΔIEC</sup> mice. In the absence of epithelial STAT1, loss of epithelial cells was abolished which was accompanied by a reduced Caspase-8 activation. Mechanistically, we demonstrate that epithelial STAT1 acts upstream of Caspase-8-dependent as well as -independent cell death and thus might play a major role at the crossroad of several central cell death pathways in the intestinal epithelium. In summary, we uncovered that transcriptional control of STAT1 is an essential host response mechanism that is required for the maintenance of intestinal barrier function and host survival.
P1‐118: Modeling Alzheimer's disease progression using hidden markov models (2011)

We propose using Hidden Markov Models (HMMs) to improve the assessment of AD progression. HMM's have been used to effectively model unobserved statistical patterns in temporal signals. For AD modeling, we consider the temporal signal to be a series of multi-dimensional biomarker feature vectors derived from the ADNI dataset. Each “hidden” state in the trained HMM is interpreted as a disease stage with an associated probability. Transition from one state to the next is governed by the model likelihood of AD progression. A six-state HMM allowing progression by one or two states or regression by one state was developed using data from 596 ADNI subjects (Normal = 182, MCI = 178, AD = 128, MCI converting to AD = 108). The data was randomly split into an HMM training set (451) and test set (145). Each state is defined by the conditional probability of the multivariate biomarker and the state transitional probabilities. The biomarkers used were change in successive visits (6 months apart) of: ventricular and brain boundary shift integral (VBSI, BSI), and normalized hippocampus volume. Missing ADNI biomarker data were linearly interpolated. Disease progression was correlated with the progression in state transitions. The probability of Normal diagnosis given a state was highest in state 1 and decreased with the state index, while the probability of AD diagnosis given a state was lowest for state 1 and increased with the state index. The probability of MCI diagnosis peaked in state 4. Specifically, as the figure shows, P[Normal|State] = 62%, 42%, 32%, 22%, 4%, and 3%, P[AD|State] = 9%, 10%, 16%, 19%, 45%, and 59%, and P[MCI|State] = 29%, 48%, 52%, 59%, 51%, and 38%, for states 1-6, respectively.
Improvement of laboratory diagnostics of urogenital chlamydial infection in patients with impaired reproductive functions found to be infected with Chlamydia trachomatis (2017)

The dominant role in human infertility has been attributed to sexually transmitted infections (STIs) with a leading contribution of urogenital chlamydial infection (UGCI) caused by Chlamydia trachomatis (CT). the two variants of this pathogen are represented by the wild-type (wtCT) and new Swedish (nvCT) strains containing 377 bp deletion within the cryptic plasmid orf1 gene. Objective. The purpose of the study was investigation of the clinical specimens obtained from the urogenital tract of couples coping with infertility for the presence of genetic material of wtCT and nvCT. Material and methods. Clinical samples (scrapings from the urethra and cervix) obtained from 25 to 41 years old couples (n = 14) were tested for the presence of identifiable wtCT and nvCT chlamydia DNA by monoplex and duplex PCR, specific antigens C. trachomatis in elementary bodies by using immunofluorescence analysis (IFA), while detection of anti-chlamydia antibodies in sera was determined by immunoenzymatic assay (IEA). Results. The nvCT variant with typical deletion of 377 bp within the orf1 gene that belongs to the genovar e subtype E1 was detected in 100% of couples with infertility. The negative results of DNA testing for wtcT were registered in 87.5% of patients from this group, while one individual (12.5%) was likely coinfected with nvCT and wtCT of E1 and D genovars, respectively. The wtCT strains of genovar E (subtypes E1, E2, E6), g (subtypes G1, G2), F (subtypes F1), and K were identified in control group among patients with UGCI. The study revealed difficulties in detection of nvCT by nucleic acid amplification test (NAAT), IFA, and IEA; data on comparison of the efficacy of these methods are presented. Conclusion. Chronic UGCI in patients with reproductive dysfunctions can be caused by nvCT alone or as result of co-infection with nvCT and wtCT. The negative results in NAAT may not 100% correlate with the absence of UGCI that requires further confirmation in tests allowing detection of all known variants of C. trachomatis.