gebhart/patrepeval huggingface dataset:
Distributed and Dynamic Mobility Management in Mobile Internet: Current Approaches and Issues (2011)

Cellular networks have been hierarchical so that mobility management have primarily been deployed in a centralized architecture. More flattened network architecture for the mobile Internet is anticipated to meet the needs of rapidly increasing traffic from the mobile users and to reduce cost in the core network. Distributing the mobility management functions as opposed to centralizing them at the root of the network hierarchy is more compatible with a flat network architecture. Mobility management may be distributed at different levels: core level, access router level, access level, and host level. It may also be partially distributed or fully distributed. A distributed mobility management architecture avoids unnecessarily long routes, is more scalable with the increasing number of mobile users, and is a convenient platform for dynamic mobility management which means providing mobility support to mobile users only when they need the support. Dynamic mobility management can avoid waste of resources and also reduce signaling overhead and network cost. The desired distributed and dynamic mobility management needs to solve existing problems, meet the needs of changes in traffic and network architecture, and be simple and inexpensive to deploy. This paper surveys existing mobility management solutions in mobile Internet, explains the limitations of a centralized mobility management approach, and discusses potential approaches of distributing mobility management functions. The issues and challenges in the design of distributed and dynamic mobility management are also described.
Effect of Attention Adaptive Personal Audio Deliverable System on Digital Signage (2019)

The purpose of this study is to improve the comfortability of the space using digital signage and the effectiveness of the advertisement to be displayed. So we have developed a system that only reached sound information to people who need it, like people watching a screen.
Evaluation of the Influence of N-Nitrosodimethyloamine (NDMA) on the Apoptosis of Neutrophils of Peripheral Blood (PMN) and the Expression of the IL-6R Membrane Receptor—in vitro Research (1999)

Evaluation of the influence of N-nitrosodimethyloamine (NDMA) on the apoptosis of neutrophils of peripheral blood (PMN) and the expression of the IL-6R membrane receptor - in vitro research. The aim of the present work was the evaluation of N-nitrosodimethyloamine (NDMA) on the induction of apoptosis in the neutrophils of peripheral blood as well as the evaluation of the surface receptors for IL-6. The isolated neutrophils were incubated for 1 and 3 hours with NDMA of a concentration of 2.5, 5, 7.5, and 10 mg/ml. In the samples incubated for 1 hour a significant, dose- dependent increase of apoptosis in the examined cells was observed. In the cells incubated for 3 hours, the increase of apoptosis was observed only at concentration of NDMA of 2.5 and 5 mg/ml. In case of higher concentration used, probably necrotic processes dominated in the cells. No influence of NDMA on the expression of IL-6R was observed.
Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts (2001)

Oxidative stress has been implicated in the pathophysiology of myocardial failure. We tested the hypothesis that oxidative stress can regulate extracellular matrix in cardiac fibroblasts. Neonatal and adult rat cardiac fibroblasts in vitro were exposed to H(2)O(2) (0.05-5 microM) or the superoxide-generating system xanthine (500 microM) plus xanthine oxidase (0.001-0.1 mU/ml) (XXO) for 24 h. In-gel zymography demonstrated that H(2)O(2) and XXO each increased gelatinase activity corresponding to matrix metalloproteinases (MMP) MMP-13, MMP-2, and MMP-9. H(2)O(2) and XXO decreased collagen synthesis (collagenase-sensitive [(3)H]proline incorporation) without affecting total protein synthesis ([(3)H]leucine incorporation). H(2)O(2) and XXO decreased the expression of procollagen alpha(1)(I), alpha(2)(I), and alpha(1)(III) mRNA but increased the expression of fibronectin mRNA, suggesting a selective transcriptional effect on collagen synthesis. H(2)O(2), but not XXO, also decreased the expression of nonfibrillar procollagen alpha(1)(IV) and alpha(2)(IV) mRNA. To determine the role of endogenous antioxidant systems, cells were treated with the superoxide dismutase (SOD) inhibitor diethyldithiocarbamic acid (DDC, 100 microM) to increase intracellular superoxide or with the glucose-6-phosphate dehydrogenase inhibitor dehydroisoandrosterone 3-acetate (DHEA; 10 microM) to increase intracellular H(2)O(2). DDC and DHEA decreased collagen synthesis and increased MMP activity, and both effects were inhibited by an SOD/catalase mimetic. Thus increased oxidative stress activates MMPs and decreases fibrillar collagen synthesis in cardiac fibroblasts. Oxidative stress may play a role in the pathogenesis of myocardial remodeling by regulating the quantity and quality of extracellular matrix.
Tests on Wave Resistance of Immersed Bodies of Revolution (1950)

In 1980, the Center for Devices and Radiological Health of the U.S. Public Health Service (PHS) conducted a survey of the numbers and types of diagnostic radiologic examinations performed in a sample of 81 general, short-stay, U.S. hospitals. Data include information on patient age and sex for all conventional radiographic, computed tomographic (CT), nuclear medicine, and ultrasound (US) procedures. An estimated 130.2 million conventional radiographic, 2.2 million CT, 6.4 million nuclear medicine, and 6.0 million US procedures were performed in all general, short-stay hospitals in 1980. Numbers and rates of procedures are presented by patient age and sex. Comparisons made to the last PHS radiographic survey in 1970 show an increase of 59% in the total number of radiographic procedures in hospitals, with the greatest increase occurring in patients in the age group 65 years and over.
Frequency response of generalized sampled-data hold functions (2002)

Alternatives to the zero order hold known as generalized sampled-data hold functions have been proposed by several authors. More recently, it has been noticed that these new holds incur intersample behavior penalties in many cases. In studying such behavior, one of the issues of relevance is the "frequency response" of the hold; for example, it is known that "nonminimum phase" zeros of the hold impose design tradeoff in the continuous-time response to disturbances of the sampled-data system. This paper goes deeper into the analysis of the frequency response of these devices, and provides some preliminary results on zero location and integral constraints satisfied by the hold. We give a number of circumstances in which nonminimum phase zeros may occur and, furthermore, we show that holds with zeros off the j/spl omega/-axis will tend to have poor frequency responses properties.
Facile and Selective O-Alkyl Transesterification of Primary Carbamates with Titanium(IV) Alkoxides (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTFacile and Selective O-Alkyl Transesterification of Primary Carbamates with Titanium(IV) Alkoxides†Gideon Shapiro and Martin MarziView Author Information Preclinical Research, Novartis Pharma Ltd, CH-4002, Basel Switzerland Cite this: J. Org. Chem. 1997, 62, 21, 7096–7097Publication Date (Web):October 17, 1997Publication History Received13 August 1997Published online17 October 1997Published inissue 1 October 1997https://pubs.acs.org/doi/10.1021/jo971498zhttps://doi.org/10.1021/jo971498zrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1685Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Aromatic compounds,Organic compounds,Pharmaceuticals,Transesterification Get e-Alerts
Über 1, 12‐Dioxa‐[12]paracyclophan‐Derivate mit einer Pseudoasymmetrieebene (1972)

Abstract ansa ‐Compounds Xa and b have been synthesized as first examples of diastereomers with a plane of pseudoasymmetry. Tentative configurations have been assigned to them on the basis of their NMR. spectra.
Increased Bacterial Burden and Infection (2006)

After reading this article and taking this test, the participant should be able to: 1. Discuss factors associated with infection of the chronic wound, including the concept of bacterial balance and burden. 2. Identify signs of infection in the chronic wound and applicable diagnostic tests. 3. Describe appropriate treatment for the infected chronic wound.
Molecular Epidemiology of American Tegumentary Leishmaniasis in Panama (2009)

American tegumentary leishmaniasis is an increasing public health problem in Panama. This study describes the clinical characteristics and the molecular epidemiology of leishmaniasis in Panama over a 5-year period (2004-2008). Additionally, we applied a polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP)-based assay to identify Leishmania species in clinical isolates, skin scrapings, and sandflies specimens. Whereas 60.3% of cases were detected with conventional parasitologic techniques (smear or in vitro culture), the PCR detected 72% positive patients. Our clinical-epidemiologic data corroborate the high incidence of L. (Viannia) panamensis and provide evidence of peridomestic and/or domestic transmission. Mucosal involvement was observed in 4.2% of the patients. The overall natural infection rate with Leishmania in 103 pools of sandflies was 0.46%. Lutzomyia gomezi and Lutzomya panamensis were the prevalent species incriminated as vectors at the capture sites in central Panama. This study contributes to a better knowledge of the current epidemiology of tegumentary leishmaniasis in Panama.
Correction to: Can levosimendan reduce ECMO weaning failure in cardiogenic shock?: a cohort study with propensity score analysis (2020)

An amendment to this paper has been published and can be accessed via the original article.
Proteomic analysis of the mammalian nuclear pore complex (2002)

As the sole site of nucleocytoplasmic transport, the nuclear pore complex (NPC) has a vital cellular role. Nonetheless, much remains to be learned about many fundamental aspects of NPC function. To further understand the structure and function of the mammalian NPC, we have completed a proteomic analysis to identify and classify all of its protein components. We used mass spectrometry to identify all proteins present in a biochemically purified NPC fraction. Based on previous characterization, sequence homology, and subcellular localization, 29 of these proteins were classified as nucleoporins, and a further 18 were classified as NPC-associated proteins. Among the 29 nucleoporins were six previously undiscovered nucleoporins and a novel family of WD repeat nucleoporins. One of these WD repeat nucleoporins is ALADIN, the gene mutated in triple-A (or Allgrove) syndrome. Our analysis defines the proteome of the mammalian NPC for the first time and paves the way for a more detailed characterization of NPC structure and function.
CAS-FEST 2010: Mitigating Variability in Near-Threshold Computing (2011)

Near threshold computing has recently gained significant interest due to its potential to address the prohibitive increase of power consumption in a wide spectrum of modern VLSI circuits. This tutorial paper starts by reviewing the benefits and challenges of near threshold computing. We focus on the challenge of variability and discuss circuit and architecture solutions tailored to three different circuit fabrics: logic, memory, and clock distribution. Soft-edge clocking, body-biasing, mismatch-tolerant memories, asynchronous operation and low-skew clock networks are presented to mitigate variability in the near threshold <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> regime.
Comprehensive assessment of cancer missense mutation clustering in protein structures (2015)

Large-scale tumor sequencing projects enabled the identification of many new cancer gene candidates through computational approaches. Here, we describe a general method to detect cancer genes based on significant 3D clustering of mutations relative to the structure of the encoded protein products. The approach can also be used to search for proteins with an enrichment of mutations at binding interfaces with a protein, nucleic acid, or small molecule partner. We applied this approach to systematically analyze the PanCancer compendium of somatic mutations from 4,742 tumors relative to all known 3D structures of human proteins in the Protein Data Bank. We detected significant 3D clustering of missense mutations in several previously known oncoproteins including HRAS, EGFR, and PIK3CA. Although clustering of missense mutations is often regarded as a hallmark of oncoproteins, we observed that a number of tumor suppressors, including FBXW7, VHL, and STK11, also showed such clustering. Beside these known cases, we also identified significant 3D clustering of missense mutations in NUF2, which encodes a component of the kinetochore, that could affect chromosome segregation and lead to aneuploidy. Analysis of interaction interfaces revealed enrichment of mutations in the interfaces between FBXW7-CCNE1, HRAS-RASA1, CUL4B-CAND1, OGT-HCFC1, PPP2R1A-PPP2R5C/PPP2R2A, DICER1-Mg2+, MAX-DNA, SRSF2-RNA, and others. Together, our results indicate that systematic consideration of 3D structure can assist in the identification of cancer genes and in the understanding of the functional role of their mutations.
Weight Equalizing Shift Scaler-Coupled Post-training Quantization (2020)

Post-training, layer-wise quantization is preferable because it is free from retraining and is hardware-friendly. Nevertheless, accuracy degradation has occurred when a neural network model has a big difference of per-out-channel weight ranges. In particular, the MobileNet family has a tragedy drop in top-1 accuracy from 70.60% ~ 71.87% to 0.1% on the ImageNet dataset after 8-bit weight quantization. To mitigate this significant accuracy reduction, we propose a new weight equalizing shift scaler, i.e. rescaling the weight range per channel by a 4-bit binary shift, prior to a layer-wise quantization. To recover the original output range, inverse binary shifting is efficiently fused to the existing per-layer scale compounding in the fixed-computing convolutional operator of the custom neural processing unit. The binary shift is a key feature of our algorithm, which significantly improved the accuracy performance without impeding the memory footprint. As a result, our proposed method achieved a top-1 accuracy of 69.78% ~ 70.96% in MobileNets and showed robust performance in varying network models and tasks, which is competitive to channel-wise quantization results.
Qualitative and Quantitative Analyses of the Three-Phase Distribution of Oil, Water, and Gas in Bentheimer Sandstone by Use of Micro-CT Imaging (2012)

Summary It is now widely acknowledged that continuous oil-spreading films observed in 2D glass-micromodel studies for strongly water-wet three-phase oil, water, and gas systems are also present in real porous media, and they result in lower tertiary-gasflood residual oil saturations than for corresponding negative spreading systems that do not display oil-spreading behavior. However, it has not yet been possible to directly confirm the presence of continuous spreading films in real porous media in three dimensions, and little is understood of the distribution of the phases within the complex geometry and topology of actual porous media for different spreading conditions. This paper describes a study with high-resolution X-ray microtomography to image the distribution of oil, water, and gas after tertiary gasflooding to recover waterflood residual oil for two sets of fluids, one positive spreading and the other negative spreading, in strongly water-wet Bentheimer sandstone. We show that, for the positive spreading system, oil-spreading films maintain the connectivity of the oil phase down to low oil saturation. At similar oil saturation, no oil films are observed for the negative spreading system, and the oil phase is disconnected. The spatial continuity of the oil-spreading films over the imaged volume is confirmed by the computed Euler characteristic for the oil phase.
A Comprehensive Analysis of Protocols for Deriving Dopaminergic Neurons from Human Pluripotent Stem Cells (2018)

The potential applications of human embryonic and induced pluripotent stem cells has led to immense interest in developing new protocols to differentiate specific cell types or modifying existing protocols. To investigate to what extent and why new protocols for the same cell types are developed and adopted, we systematically evaluated 158 publications (2004-2017) that differentiated human stem cells into dopaminergic neurons. We categorized each article by degree of novelty and recorded motivations for protocol development. 74 novel or modified protocols were developed. Most (65%) were not used again in subsequent studies. Diverse motivations were recorded and performance of new methods was assessed with substantially different approaches across studies. There was improvement over time in yield of neuron production, but not in yield of dopaminergic neurons or time required for getting neurons. Standardized reporting of performance metrics may help rational choice of the best methods. Stem Cells Translational Medicine 2019;8:366-374.
Estimation of exogenous traffic based on link measurements in circuit-switched networks (1995)

The intensity of exogenous traffic is a critical input to a variety of network functions, including routing, flow control, and capacity planning. Currently, however, the scope of measurements in a large scale, circuit-switched network is quite limited and does not include gathering of the exogenous traffic intensity in real-time. This paper formulates methods of estimating the exogenous traffic intensity, without requiring additional measurements beyond what is currently available. The performance of the proposed methods is compared based on network simulations and is shown to be accurate and robust.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Thermal Isomerization of 4-Amino-3-vinylpyridines: Synthesis of Fused 1,6-Naphthyridines and Unexpected New ”tert-Amino Effect” Cyclization to Azepines (1995)

4-amino-3-(2,2-dicyanovinyl)pyridines react thermally in dimethylsulfoxide via [1,5] hydrogen transfer followed by carbon-carbon bond formation to give hexahydro-1H-amino[1,2-a][1,6]naphthyridine derivatives. The 4-piperazino, 4-morpholino- and 4-thiomorpholino-3-(2,2-dicyanovinyl)pyridines also lend themselves to the simultaneous formation of hexahydro-1H-imidazolo[2,1-f]pyrido[4,3-b]azepine, hexahydro-1H-oxazolo[2,3-g]pyrido[4,3-b]azepine and hexahydro-1H-pyrido[3,4-f]thiazolo[3,2-a]azepine derivatives, respectively, by a new "tert-amino effect" type of cyclization. A rational explanation for the new reactivity based on a neighboring-group mechanism is put forward.
Morphinane Alkaloids with Cell Protective Effects from Sinomenium acutum (2005)

One new morphinane alkaloid, sinomenine N-oxide (1), and one new natural occurring morphinane alkaloid, N-demethylsinomenine (2), together with six known alkaloids, 7,8-didehydro-4-hydroxy-3,7-dimethoxymorphinan-6-ol (3), sinomenine (4), sinoacutine (5), N-norsinoacutine, acutumine, and acutumidine, were isolated from the stems of Sinomenium acutum. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. Compounds 2, 3, and 5 have protective effects against hydrogen peroxide-induced cell injury.
Impedance-Based Cell Culture Platform To Assess Light-Induced Stress Changes with Antagonist Drugs Using Retinal Cells (2013)

This Article describes an unprecedented, simple, and real-time in vitro analytical tool to measure the luminous effect on the time responses function of retinal ganglion cells (RGC-5) by electric cell substrate impedance sensing (ECIS) system. The ECIS system was used for the continuous measurement of different color light-induced effects on the response of cells that exposed to protective drugs. The measurement suggests that the association of photo-oxidative stress was mediated by reactive oxygen species (ROS), which plays a critical role that leads to cell stress, damages, and retinopathy, resulting in eye degenerative diseases. Continuous light radiation caused time-dependent decline of RGC-5 response and resulted in photodamage within 10 h due to adenosine 5'-triphosphate depletion and increased ROS level, which is similar to in vivo photodamage. The ECIS results were correlated with standard cell viability assay. ECIS is very helpful to determine the protective effects of analyzed drugs such as β-carotene, quercetin, agmatine, and glutathione in RGC-5 cells, and the maximum drug activity of nontoxic safer drug concentrations was found to be 0.25, 0.25, 0.25, and 1.0 mM, respectively. All drugs show protection against light radiation toxicity in a dose-dependent manner; the most effective drug was found to be glutathione. The proposed system identifies the phototoxic effects in RGC-5 and provides high throughput drug screening for photo-oxidative stress during early stages of drug discovery. This study is convenient and potential enough for the direct measurements of the photoprotective effect in vitro and would be of broad interest in the field of therapeutics.