gebhart/patrepeval huggingface dataset:
Cavity Procurement and Qualification Plan for LCLS-II (2015)

The LCLS-II project aims to build 35 accelerating cryomodules, which are based on the European XFEL design but modified for operation in CW mode. Each cryomodule houses eight TESLA-style nine-cell superconducting radio-frequency cavities. The activities to assemble the first two prototype cryomodules are ongoing at FNAL and JLab. 264 cavities worth of cavities for the remaining 33 cryomodules will be procured from two industrial vendors in similar quantity considering the option to produce spares. The assembly of cavities into the production cryomodules will be distributed among FNAL (16 cryomodules) and JLab (17 cryomodules). In this paper the cavity procurement and qualification plan for the LCLS-II project is detailed.
Solvatochromic behavior of intramolecular charge-transfer diphenylpolyenes in homogeneous solution and microheterogeneous media (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvatochromic behavior of intramolecular charge-transfer diphenylpolyenes in homogeneous solution and microheterogeneous mediaDong Myung Shin and David G. WhittenCite this: J. Phys. Chem. 1988, 92, 10, 2945–2956Publication Date (Print):May 1, 1988Publication History Published online1 May 2002Published inissue 1 May 1988https://pubs.acs.org/doi/10.1021/j100321a046https://doi.org/10.1021/j100321a046research-articleACS PublicationsRequest reuse permissionsArticle Views370Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Interactive Geometry Decals (2009)

We present a novel real-time method for geometric displacement mapping on arbitrary 2-manifold triangle meshes. It is independent of the surface resolution and allows very fine geometric details to be added. We first compute a local surface parameterization using barycentric particle tracing and a constrained mass-spring system. This system satisfies the hard constraint of keeping all mass points on the surface. We propose a novel, entangled spring topology that is regularly 6-connected and has a chromatic number of 2. Therefore, the system can be efficiently solved on the GPU using a Gauss-Seidel solver. To render the displaced surface, we introduce a new GPU technique to cut out a surface patch at sub-pixel precision. The displacement mesh is then smoothly blended into the resulting opening. We show that our method overcomes common problems of displacement mapping such as limited resolution of the base surface and the need for a low-distortion global parameterization. 1
Biochemical and spectroscopic characterization of Escherichia coli aconitases (AcnA and AcnB) (1999)

Escherichia coli contains two major aconitases (Acns), AcnA and AcnB. They are distantly related monomeric Fe-S proteins that contain different arrangements of four structural domains. On the basis of the differential expression of the acnA and acnB genes, AcnA has been designated as an aerobic-stationary-phase enzyme that is specifically induced by iron and oxidative stress, whereas AcnB functions as the major citric-acid-cycle enzyme during exponential growth. The biochemical and kinetic properties of the purified enzymes have now shown that AcnA is more stable than AcnB, has a higher affinity for citrate, and operates optimally over a wider pH range, consistent with its role as a maintenance or survival enzyme during nutritional or oxidative stress. In contrast, the better performance at high substrate concentrations and greater instability of AcnB indicate that AcnB is specifically adapted to function as the main catabolic enzyme and, by inactivation, to rapidly modulate energy metabolism in response to oxidative or pH stress, either directly or indirectly by regulating post-transcriptional gene expression. EPR and magnetic-CD spectroscopy showed that the iron-sulphur clusters of the bacterial Acns (and their binding sites) strongly resemble those of the mammalian enzymes. The EPR and MCD spectra of the oxidized inactive form of AcnB confirmed the presence of a [3Fe-4S](1+) (S=1/2) cluster. Comparisons showed that the EPR spectrum of AcnB more closely resembled that of mammalian mitochondrial Acn (m-Acn), whereas the spectrum of AcnA more closely resembled that of the cytoplasmic enzyme (c-Acn). The MCD spectra revealed spectroscopic signatures similar to that of m-Acn. Reconstitution of the active [4Fe-4S](2+) forms followed by one-electron reduction gave rise to EPR spectra that are almost identical with those reported for the mammalian enzymes.
Spreading of triboelectrically charged granular matter (2014)

We report on the spreading of triboelectrically charged glass particles on an oppositely charged surface of a plastic cylindrical container in the presence of a constant mechanical agitation. The particles spread via sticking, as a monolayer on the cylinder's surface. Continued agitation initiates a sequence of instabilities of this monolayer, which first forms periodic wavy-stripe-shaped transverse density modulation in the monolayer and then ejects narrow and long particle-jets from the tips of these stripes. These jets finally coalesce laterally to form a homogeneous spreading front that is layered along the spreading direction. These remarkable growth patterns are related to a time evolving frictional drag between the moving charged glass particles and the countercharges on the plastic container. The results provide insight into the multiscale time-dependent tribolelectric processes and motivates further investigation into the microscopic causes of these macroscopic dynamical instabilities and spatial structures.
Interactions between cochlear implant electrode insertion depth and frequency-place mapping (2005)

While new electrode designs allow deeper insertion and wider coverage in the cochlea, there is still considerable variation in the insertion depth of the electrode array among cochlear implant users. The present study measures speech recognition as a function of insertion depth, varying from a deep insertion of 10 electrodes at 28.8 mm to a shallow insertion of a single electrode at 7.2 mm, in four Med-El Combi 40+ users. Short insertion depths were simulated by inactivating apical electrodes. Speech recognition increased with deeper insertion, reaching an asymptotic level at 21.6 or 26.4 mm depending on the frequency-place map used. Başkent and Shannon [J. Acoust. Soc. Am. 116, 3130-3140 (2004)] showed that speech recognition by implant users was best when the acoustic input frequency was matched onto the cochlear location that normally processes that frequency range, minimizing the spectral distortions in the map. However, if an electrode array is not fully inserted into the cochlea, a matched map will result in the loss of considerable low-frequency information. The results show a strong interaction between the optimal frequency-place mapping and electrode insertion depth. Consistent with previous studies, frequency-place matching produced better speech recognition than compressing the full speech range onto the electrode array for full insertion ranges (20 to 25 mm from the round window). For shallower insertions (16.8 and 19.2 mm) a mild amount of frequency-place compression was better than truncating the frequency range to match the basal cochlear location. These results show that patients with shallow electrode insertions might benefit from a map that assigns a narrower frequency range than patients with full insertions.
Temperature-Responsive Chromatography Using Poly(N-isopropylacrylamide)-Modified Silica (1996)

A new concept in chromatography is proposed that utilizes a temperature-responsive surface with a constant aqueous mobile phase. The surface of the silica stationary phase in high-performance liquid chromatography (HPLC) has been modified with temperature-responsive polymers to exhibit temperature-controlled hydrophilic/hydrophobic changes. Poly(N-isopropylacrylamide) (PIPAAm) was grafted onto (aminopropyl)silica using an activated ester-amine coupling method. These grafted silica surfaces show hydrophilic properties at lower temperatures which, as temperature increases, transform to hydrophobic surface properties. The elution profile of five mixed steroids on an HPLC column packed with this material depends largely on the temperature of the aqueous mobile phase. Retention times increase with increasing temperature without any change in the eluent. Changes in the retention times of hydrophobic steroids were larger than those for hydrophilic steroids. The temperature-responsive interaction between PIPAAm-modified silica and these steroids is proposed to result from changes in the surface properties of the HPLC stationary phase by the transition of hydrophilic/hydrophobic surface-grafted IPAAm polymers. We demonstrate a novel and useful new chromatography system in which surface properties and the resulting function of the HPLC stationary phase are controlled by external temperature changes. This method should be effective in biological and biomedical separations of peptides and proteins using only aqueous mobile phases.
Multiplexed intrinsic optical fibre Fabry-Pérot temperature and strain sensors addressed using white-light interferometry (1999)

The construction and application of low-finesse, intrinsic fibre-optical Fabry-Pérot interferometric sensors is presented. These sensors were interrogated using white-light interferometry. Broadband Fabry-Pérot cavities were formed by pairs of dielectric mirrors prepared by coating the core region of single-mode fibre with titanium dioxide before fusion splicing. We obtained sensor responses to temperature and strain variations with resolutions of 0.01 °C and 0.07 µ, respectively. Multiplexing of two of these sensors was demonstrated both in parallel and in serial arrangements, the latter of which is readily extended to more than five sensors with little increase in system complexity.
Die Struktur des Antibioticums Roridin H. Verrucarine und Roridine, 20. Mitt. [1] (1970)

Abstract Structure 1 has been established for roridin H (C 29 H 36 O 8 ), an antibiotic isolated from Myrothecium verrucaria and formerly namend verrucarin H [3]. Base catalysed hydrolysis of 1 gave the known terpene alcohol verrucarol ( 8 ; C 15 H 22 O 4 ) and myrothecinic acid ( 3 ; C 14 H 18 O 6 ), a previously undescribed dicarboxylic acid. The structure of 3 was determined by spectral methods and by chemical cleavage of the unusual acetal group of dimethyl hexahydromyrothecinoate ( 6 ) by hydrolysis with HCl in the presence of 2, 4‐dinitrophenylhydrazine, producing the 2, 4‐dinitrophenylhydrazone 13 of 3‐methylglutaric acid semialdehyde 10 and methyl 6, 7‐dihydroxy‐octanoate ( 11 ). 13 was transformed in to dimethyl 3‐methylglutarate ( 15 ). Cleavage of 11 with HIO 4 gave acetaldehyde and adipic acid semialdehyde ( 17 ) which was oxidized to adipic acid ( 19 ). The 220 MHz NMR spectra of roridin H ( 1 ) and dimethyl hexahydromyrothecinoate ( 6 ) allowed unequivocal assignment of the signals to the majority of the protons in the antibiotic.
Notiz zur Synthese von Alkyl‐, Cycloalkyl‐ und Aryl‐(4‐aminophenyl)‐sulfonen (1983)

Syntheses of Some Alkyl‐, Cycloalkyl‐ and Aryl‐(4‐aminophenyl)‐sulfones Syntheses of (4‐aminophenyl)‐alkyl, ‐cycloalkyl and ‐aryl sulfones 2 were achieved both by alkylation of 4‐(acetylamino)‐benzenesulfinic acid ( 7 ) to the corresponding acetanilides 9 followed by hydrolysis and by oxidation of the appropriate (4‐nitrophenyl)‐sulfides 11 to (4‐nitrophenyl)‐sulfones 1 with subsequent Béchamp reduction.
NUCLEAR MAGNETIC RESONANCE STUDY ON SOLVENT DEPENDENCE OF SIDE CHAIN CONFORMATIONS OF TYROSINE AND TRYPTOPHAN DERIVATIVES (1981)

The stereoselectively beta-deuterated species of Ac-Ar-NHMe, Ac-Ar-OH and Ac-Ar-OEt (Ar = Tyr and Trp) and H-Trp-NHMe were synthesized. 270-MHz 1H n.m.r. spectra of the normal and deuterated species of these aromatic amino acid derivatives were analyzed. For most of the tyrosine and tryptophan derivatives in various polar and nonpolar solvents, the lower-field and higher-field beta-proton signals were found to be due to the pro-S and pro-R protons, respectively. However, the alternative assignments apply for H-Trp-NHMe in aqueous solution and for Ac-Tyr-NHMe and Ac-Trp-NHMe in nonpolar solvents. Such alternative assignments of beta-proton signals were also found for H-Phe-NHMe, Ac-PHe-NMe2 and Ac-Phe-OtBu. From the analyses of the 1H n.m.r. spectra of tyrosine and tryptophan derivatives, the vicinal coupling constants and rotamer populations about the C alpha-C beta bond were determined in various solvents. The rotamer populations of H-Trp-NHMe, Ac-Ar-NHMe, Ac-Ar-OH and Ac-Ar-OEt depend significantly on solvent polarity. Each of these four types of derivatives exhibits specific solvent-polarity dependences of rotamer populations. The solvent dependences of rotamer populations were substantially reduced on replacement of alpha-carbonyl group by methylene group, suggesting the effect of this carbonyl group in the solvent dependence of rotamer populations.
Identification of the transforming activity of Indian hedgehog by retroviral expression screening (2009)

To identify novel cancer-promoting genes in biliary tract cancer (BTC), we constructed a retroviral cDNA expression library from a clinical specimen of BTC with anomalous pancreaticobiliary duct junction (APBDJ), and used the library for a focus formation assay with 3T3 fibroblasts. One of the cDNAs rescued from transformed foci was found to encode Indian hedgehog homolog (IHH). The oncogenic potential of IHH was confirmed both in vitro with the focus formation assay and in vivo with a tumorigenicity assay in nude mice. The isolated IHH cDNA had no sequence alterations, suggesting that upregulation of IHH expression may contribute to malignant transformation. Quantitation of IHH mRNA among clinical specimens has revealed that the expression level of IHH in BTC with APBDJ is higher than that in BTC without APBDJ and than in non-cancerous biliary tissues. Our data thus implicate a direct role of IHH in the carcinogenesis of BTC with APBDJ.
87. Heart and Lung Transplants From HCV-Viremic Donors to Uninfected Patients: Longer-Term Follow-Up (2019)

Abstract Background The DONATE HCV Trial demonstrated that hearts and lungs can be safely transplanted from HCV-infected donors using a shortened, 4-week, pre-emptive course of direct-acting antivirals (DAA). The 6-month results from that study of 35 patients are encouraging, but longer-term data from a larger cohort are needed to better define the risk–benefit profile. Methods We conducted a single-center trial to transplant thoracic organs from HCV viremic donors, irrespective of HCV genotype, to HCV-uninfected adults. Sofosbuvir/velpatasvir, a pan-genotypic DAA, was pre-emptively administered for 4 weeks, beginning within hours of transplant. The primary outcome was a composite of HCV clearance and graft survival at 6 months post-transplant. Secondary outcomes included graft survival and mortality at 12 months and the occurrence of grade 3 or higher adverse events (AEs). This protocol is IRB approved and all participants provided written informed consent (NCT03086044). Results Between March 2017 and March 2019, 57 participants were enrolled: 46 received lung and 11 received heart transplants. The median donor HCV viral load (VL) was 889,817 IU/mL (IQR 212,062–4,641,078). Of the 57 recipients, 53 (93%) had detectable HCV VL immediately after transplant, with median VL of 1,460 IU/mL (IQR 463–6,618). HCV VL became negative by about 2 weeks and subsequently remained undetectable in all participants. Forty-nine of 49 (100%) and 34 of 35 (97%) participants were alive with excellent graft function and an undetectable HCV VL at 6 months and 1-year post-transplant, respectively. No treatment-related serious AEs were identified. Outcomes between transplant recipients from HCV donors vs. non-HCV donors were similar, including the occurrence of renal failure, respiratory failure, and non-HCV infections. Conclusion In patients who received thoracic organs from HCV viremic donors, a 4-week antiviral treatment course initiated within hours of transplant prevented the establishment of HCV infection. These data demonstrate that thoracic organs from HCV viremic donors can be transplanted safely with excellent graft and recipient survival at 12 months with a similar AE profile compared with transplant recipients who received thoracic organs from non-HCV donors. Two-year outcomes will be available in October 2019. Disclosures All Authors: No reported Disclosures.
Generating entanglement between quantum dots with different resonant frequencies based on dipole-induced transparency (2008)

We describe a method for generating entanglement between two spatially separated dipoles coupled to optical microcavities. The protocol works even when the dipoles have different resonant frequencies and radiative lifetimes. This method is particularly important for solid-state emitters, such as quantum dots, which suffer from large inhomogeneous broadening. We show that high fidelities can be obtained over a large dipole detuning range without significant loss of efficiency. We analyze the impact of higher-order photon number states and cavity resonance mismatch on the performance of the protocol.
Organic, Organometallic and Bioorganic Catalysts for Electrochemical Reduction of CO2 (2017)

A broad review of homogeneous and heterogeneous catalytic approaches toward CO<sub>2</sub> reduction using organic, organometallic, and bioorganic systems is provided. Electrochemical, bioelectrochemical and photoelectrochemical approaches are discussed in terms of their faradaic efficiencies, overpotentials and reaction mechanisms. Organometallic complexes as well as semiconductors and their homogeneous and heterogeneous catalytic activities are compared to enzymes. In both cases, their immobilization on electrodes is discussed and compared to homogeneous catalysts in solution.
Zinc(II) and copper(II) binding to serum albumin. A comparative study of dog, bovine, and human albumin. (1994)

Metal binding strategies employing low molecular weight chelators and equilibrium dialysis were used to investigate several unresolved aspects of zinc and copper binding to serum albumin. Direct measurement of histidine binding to bovine serum albumin when the histidine is presented either as a metal-chelate or alone provides no evidence for an albumin-metal-histidine ternary complex. Using previously determined intrinsic constants for Zn(II) and Cu(II), we have measured zinc binding to bovine serum albumin in the presence of saturating amounts of copper. The results of these experiments unambiguously show that zinc and copper bind at separate noninteracting sites on this protein. The intrinsic constants for zinc and copper binding to dog serum albumin have been determined. Contrary to previous reports, we find that dog serum albumin has a specific high affinity site for copper, log10K 10.17 for Cu(II) compared to 6.85 for Zn(II) at the separate site.
Schizophrenia and Other Psychosis in Asians and Asian Americans (2012)

Chapter 5 explores schizophrenia and other psychosis in Asians and Asian Americans. It includes issues related to nosology and manifestations of psychosis (epidemiology, symptomatology, culture-bound symptoms, differential diagnosis and misdiagnosis, and the degree of fit between DSM nosology/diagnostic schemes and Asian populations. Etiological model are discussed ('biological' models, environmental effects mediated through 'biological' mechanisms, psychosocial etiological models, etiological models and Asian populations), issues related to the treatment, clinical course, and outcome, family involvement, and stigma.
Rapid Manipulation of the Spatial Coherence (2015)

Efficient method for manipulating the spatial coherence of a laser is presented. Different mutual intensity coherence functions, such as cosine or Bessel functions, are obtained, and number of modes is controlled in 1D and 2D.
In vitro comparative evaluations of the postantifungal effect: synergistic interaction between flucytosine and fluconazole against Candida albicans (1991)

In vitro comparative evaluations were performed to study the efficacy of combinations of flucytosine and fluconazole in producing a postantifungal effect (PAFE) on Candida albicans. Initial studies were done to determine MIC, FIC (fractional inhibitory concentration) and optimal PAFE parameters. A turbidometric method was used to measure yeast cell growth following exposure to different concentrations of the two drugs for periods of 0.5, 1 or 2 h at temperatures of 30 degrees C and 37 degrees C. The PAFE was determined by the difference in time (h) required for growth of the control and test cultures to reach the 0.5 absorbance level following removal of the drug by dilution. Ten strains of C. albicans were then assayed (30 degrees C; 2 h exposure time) and a synergistic PAFE was evidenced with the two drugs at concentrations well below their individual MICs. PAFEs ranging from 3.8 to 10.5 h, which persisted for 1.2-2.5 h longer than those achieved with either agent separately, were evidenced when flucytosine and fluconazole were combined (flucytosine: fluconazole ratios of 1:16-1:32) at concentrations ranging from 0.024 to 0.098 micrograms ml-1 and 0.78 to 1.56 micrograms ml-1 respectively. The concentrations of each agent required to produce an optimal PAFE varied according to the C. albicans strain being assayed.
Multirate adaptive inferential estimation (1992)

An adaptive inferential algorithm is developed for estimation and control of multirate systems. The output y is measured J times slower than the secondary process output v and the input u, but an output estimate Ye is produced at each sampling interval of v and u. Compared with previous work on multirate inferential systems, the proposed algorithm has a more formal theoretical basis. For example, the output y is related to the secondary output v not only through external stochastic disturbances but also through the internal system structure. Convergence properties are formally proven for the case of zero external stochastic disturbances, and a simplified algorithm is proposed for practical applications. Simulated results illustrate the convergence properties of the algorithm and the improvement obtained in simple feedback control systems.