gebhart/patrepeval huggingface dataset:
Genetic Variants Associated with Circulating Parathyroid Hormone (2016)

Parathyroid hormone (PTH) is a primary calcium regulatory hormone. Elevated serum PTH concentrations in primary and secondary hyperparathyroidism have been associated with bone disease, hypertension, and in some studies, cardiovascular mortality. Genetic causes of variation in circulating PTH concentrations are incompletely understood. We performed a genome-wide association study of serum PTH concentrations among 29,155 participants of European ancestry from 13 cohort studies (<i>n</i>=22,653 and <i>n</i>=6502 in discovery and replication analyses, respectively). We evaluated the association of single nucleotide polymorphisms (SNPs) with natural log-transformed PTH concentration adjusted for age, sex, season, study site, and principal components of ancestry. We discovered associations of SNPs from five independent regions with serum PTH concentration, including the strongest association with rs6127099 upstream of <i>CYP24A1</i> (<i>P</i>=4.2 × 10<sup>-53</sup>), a gene that encodes the primary catabolic enzyme for 1,25-dihydroxyvitamin D and 25-dihydroxyvitamin D. Each additional copy of the minor allele at this SNP associated with 7% higher serum PTH concentration. The other SNPs associated with serum PTH concentration included rs4074995 within <i>RGS14</i> (<i>P</i>=6.6 × 10<sup>-17</sup>), rs219779 adjacent to <i>CLDN14</i> (<i>P</i>=3.5 × 10<sup>-16</sup>), rs4443100 near <i>RTDR1</i> (<i>P</i>=8.7 × 10<sup>-9</sup>), and rs73186030 near <i>CASR</i> (<i>P</i>=4.8 × 10<sup>-8</sup>). Of these five SNPs, rs6127099, rs4074995, and rs219779 replicated. Thus, common genetic variants located near genes involved in vitamin D metabolism and calcium and renal phosphate transport associated with differences in circulating PTH concentrations. Future studies could identify the causal variants at these loci, and the clinical and functional relevance of these variants should be pursued.
Development of New Transparent Conductive Material of Mg(OH 1‐x C x ) 2 (x = 0.1‐0.35) by Magnetron Sputtering (2011)

This chapter contains sections titled: Introduction Experimental procedures Results and discussions Conclusion Acknowledgement Figure captions
Steerable PCA for Rotation-Invariant Image Recognition (2015)

In this paper, we propose a continuous-domain version of principal-component analysis, with the constraint that the underlying family of templates appears at arbitrary orientations. We show that the corresponding principal components are steerable. Our method can be used for designing steerable filters so that they best approximate a given collection of reference templates. We apply this framework to the detection and classification of micrometer-sized particles that are used in a microfluidic diagnostics system. This is done in two steps. First, we decompose the particles into a small number of templates and compute their steerable principal components. Then we use these principal components to automatically estimate the orientation and the class of each particle.
Structure study of hydrated Zr(1%Nb) reactor fuel tube cladding material (2002)

The evaluation of the influence of three most important parameters of synthesis on the structure-texture properties of mesostructured silica, prepared using PLURONIC P123 as a surfactant under weak acidic conditions is reported. These most important parameters are: (1) mixing time, (2) conditions of hydrothermal treatment, and (3) final mixture pH. Aqueous solutions of sodium silicate and hydrochloric acid were used as starting reagents for the syntheses. The results show that both structure and texture properties of mesostructured silica may be varied widely using these parameters. Two most interesting types of mesostructured silica were revealed as a result of this work. The first one includes the systems prepared at relatively short mixing times followed by hydrothermal treatment at relatively low temperatures. The texture of these systems may be described as three dimensional, since it consists of primary (large) and complementary (small and middle) mesopores. This type of systems are very promising for using as templates for synthesys of various derivatives such as mesostructured carbon (e.g., CMK-3). The second one represents the systems prepared at relatively long mixing times and at the mixture pH range of about 3-3.5 followed by hydrothermal treatment at appropriate temperatures. These systems exhibit: (a) highly ordered hexagonal mesostructure of uniformly sized mesopores (without any complementary ones); (b) negligible lattice contraction during calcination, and (c) high stability of the mesostructure relative to additional treatments of calcined forms. This type of systems has to be considered as very promising basis for synthesis of mesostructured element-silicate heterogeneous catalysts.
Chronic neutrophilic leukemia--report of a case and review of the literature. (1990)

A male patient, aged 78, was found with chronic neutrophilic leukemia (CNL). The patient showed sustained mature neutrophilic leukocytosis, splenomegaly, a high leukocyte alkaline phosphatase score, elevated serum vitamin B12 and uric acid, myeloid hyperplasia and absence of ph' chromosome in the bone marrow, with no evidence suggesting this condition to be a leukemoid reaction to an underlying disease. In addition to the above mentioned features, some functional characteristics of CNL cells were compared with normal cells. CNL is a very rare disease; some thought it as a variant of chronic myelogenous leukemia (CML). In this report a review of the literature is also included.
T020: Interim PET-guided treatment of early-stage nodular lymphocyte-predominant Hodgkin lymphoma: a subgroup analysis of the GHSG HD16 and HD17 studies (2022)

Background: The optimal treatment for patients with early-stage nodular-lymphocyte predominant Hodgkin lymphoma (NLPHL) other than stage IA is undefined. Patients and Methods: We investigated characteristics and outcomes of patients with early-stage NLPHL (favorable: 85 patients; unfavorable: 15 patients) who had treatment within the randomized GHSG HD16 and HD17 studies. Results were compared to those from patients with classical Hodgkin lymphoma (cHL) (favorable: 495 patients; unfavorable: 764 patients) treated within the same studies. Chemotherapy consisted of 2 cycles of ABVD (HD16) or 2 cycles of escalated BEACOPP plus 2 cycles of ABVD („2 + 2“) (HD17). In the experimental study arms, consolidation radiotherapy (RT) was applied on the basis of the result of interim positron emission tomography (PET-2). In the standard arms, consolidation RT was mandatory. Progression-free survival (PFS) and overall survival (OS) were analyzed using the Kaplan-Meier method. Results: In the HD16 and HD17 studies, 62/85 (73%) and 13/15 (87%) NLPHL patients were male as compared to 254/495 (51%) and 337/764 (44%) cHL patients. The median age of patients with NLPHL was 37 years in the HD16 study (cHL: 36 years) and 42 years in the HD17 study (cHL: 31 years). The majority of NLPHL patients included in the HD16 and HD17 studies presented with a typical histopathological growth pattern (HD16: 66%; HD17: 70%) The 5-year PFS for all NLPHL patients was 90.3% (cHL: 90.8%) in the HD16 study and 92.9% (cHL: 95.7%) in the HD17 study. In the HD16 study, the 5-year PFS for the subgroup of PET-2-positive NLPHL patients was 89.3% (cHL: 91.6%); PET-2-negative NLPHL patients had a 5-year PFS of 91.0% (cHL: 90.4%). For PET-2-negative NLPHL patients assigned to the chemotherapy only arm, the 5-year PFS was 83.0% (cHL: 88.2%) whereas PET-2-negative NLPHL patients treated with chemotherapy plus RT had a 5-year PFS of 100% (cHL: 92.3%) (p=0.05). Subgroup analyses according to the PET-2 result were not conducted for NLPHL patients treated within the HD17 study due to the small number of individuals with NLPHL histology included in this trial. The 5-year OS for NLPHL patients treated within the HD16 and HD17 studies was 100% (cHL: 98.6% in HD16; 99.2% in HD17). Conclusion: Contemporary HL-directed treatment results in excellent 5-year outcomes for patients with newly diagnosed early-stage NLPHL and should thus be considered as valid approach for this patient group.
Render for CNN: Viewpoint Estimation in Images Using CNNs Trained with Rendered 3D Model Views (2015)

Object viewpoint estimation from 2D images is an essential task in computer vision. However, two issues hinder its progress: scarcity of training data with viewpoint annotations, and a lack of powerful features. Inspired by the growing availability of 3D models, we propose a framework to address both issues by combining render-based image synthesis and CNNs (Convolutional Neural Networks). We believe that 3D models have the potential in generating a large number of images of high variation, which can be well exploited by deep CNN with a high learning capacity. Towards this goal, we propose a scalable and overfit-resistant image synthesis pipeline, together with a novel CNN specifically tailored for the viewpoint estimation task. Experimentally, we show that the viewpoint estimation from our pipeline can significantly outperform state-of-the-art methods on PASCAL 3D+ benchmark.
Characterization of Enzyme-Redox Hydrogel Thin-Film Electrodes for Improved Utilization (2014)

Homogeneous, sub-micron thick bioactive films containing redox hydrogels and the enzyme laccase were prepared on gold-coated glass slides via convective self-assembly. Sub-micron film thickness (∼10–50 nm) allowed higher mediator and enzyme utilization by lowering transport limitations. This study demonstrates control of redox hydrogel film morphology by manipulating hydrophilicity, spreading and wetting properties of the hydrogel/electrode interface. Use of a non-ionic surfactant (Triton X-100) enabled spreading of enzyme containing precursor solutions with no negative impact on enzyme activity. Ellipsometry was used to measure film-swelling properties of these systems, square wave voltammetry was employed to estimate the amount of electroactive redox polymer, and cyclic voltammetry enabled estimation of apparent electron diffusivity. This study impacts the design of thin, catalytic films for bioelectronic applications.
Influence of the oxygen concentration of atomic-layer-deposited HfO2 gate dielectric films on the electron mobility of polycrystalline-Si gate transistors (2006)

The influence of the ozone concentration (150–370g∕m3) during the atomic layer deposition of HfO2 gate dielectrics on the dielectric performance of the films and the device performance of metal-oxide-semiconductor field effect transistor (MOSFET) grown on Si was studied. The use of a lower ozone concentration (150g∕m3) produced a HfO2 film with a stoichiometric oxygen concentration, whereas a higher ozone concentration (390g∕m3) produced an oxygen excess HfO2 film. An almost identical Dit to that of the SiO2 gate dielectric film was obtained from the stoichiometric HfO2, whereas the oxygen excess HfO2 gate dielectric produced a much higher Dit with the polycrystalline-Si electrode. The investigation of the interface states using x-ray photoelectron spectroscopy revealed that the excessive oxygen incorporated during the film growth made the interfacial reaction and oxidation serious. This increased the interface trap density and degraded the interface properties. Accordingly, an electron effective mobility of ∼65% of the MOSFET with SiO2 as a gate dielectric was obtained from the stoichiometric HfO2 gate dielectric film. The effective mobility from the MOSFET with the oxygen excess HfO2 film was only ∼45%. The 35% loss of the effective mobility for the stoichiometric HfO2 MOSFET appeared to be due to factors such as carrier scattering by fixed charges and long range optical phonons.
Processing and morphology of molecularly imprinted nylon thin films (2006)

Abstract The characterization of thin, selectively imprinted films of nylon‐6 was performed. Amino acids were used as template molecules. Spin‐cast films were prepared with sizes ranging from 2 μm to 300 nm, depending on the nylon and template concentration in the casting solution. The morphological characteristics of the film surface were examined by atomic force microscopy, and the structure within the films was observed by freeze‐fracture scanning electron microscopy. The film activity was clearly coordinated with the appearance of nanometer‐sized pores both on the surface and within the film. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 101: 2919–2926, 2006
Three-dimensional Myoblast Aggregates--Effects of Modeled Microgravity (2006)

The overall objective of these studies is to elucidate the molecular and cellular alterations that contribute to muscle atrophy in astronauts caused by exposure to microgravity conditions in space. To accomplish this, a three-dimensional model test system was developed using mouse myoblast cells (C2C12). Myoblast cells were grown as three-dimensional aggregates (without scaffolding or other solid support structures) in both modeled microgravity (Rotary Cell Culture System, Synthecon, Inc.) and at unit gravity in coated Petri dishes. Evaluation of HE 2) gene expression alterations occur rapidly (within 12 hours) following exposure to modeled microgravity; and 3) modeled microgravity conditions stimulated myoblast cell differentiation. Achieving a greater understanding of the molecular alterations leading to muscle atrophy will eventually enable the development of cell-based countermeasures, which may be valuable for treatment of muscle diseases on Earth and future space explorations.
Virus Detection: A Review of the Current and Emerging Molecular and Immunological Methods (2021)

Viruses are ubiquitous in the environment. While many impart no deleterious effects on their hosts, several are major pathogens. This risk of pathogenicity, alongside the fact that many viruses can rapidly mutate highlights the need for suitable, rapid diagnostic measures. This review provides a critical analysis of widely used methods and examines their advantages and limitations. Currently, nucleic-acid detection and immunoassay methods are among the most popular means for quickly identifying viral infection directly from source. Nucleic acid-based detection generally offers high sensitivity, but can be time-consuming, costly, and require trained staff. The use of isothermal-based amplification systems for detection could aid in the reduction of results turnaround and equipment-associated costs, making them appealing for point-of-use applications, or when high volume/fast turnaround testing is required. Alternatively, immunoassays offer robustness and reduced costs. Furthermore, some immunoassay formats, such as those using lateral-flow technology, can generate results very rapidly. However, immunoassays typically cannot achieve comparable sensitivity to nucleic acid-based detection methods. Alongside these methods, the application of next-generation sequencing can provide highly specific results. In addition, the ability to sequence large numbers of viral genomes would provide researchers with enhanced information and assist in tracing infections.
Novel Inhibitors of Matrix Metalloproteinase Gene Expression as Potential Therapies for Arthritis (2004)

Matrix metalloproteinases are a family of endopeptidases that collectively degrade all components of the extracellular matrix at neutral pH. During the progression of arthritis, MMPs mediate the degradation of cartilage, which consists largely of Type II collagen fibrils and proteoglycans. The collagenases, a subgroup of MMPs, have the singular ability to cleave intact collagens and may provide a rate-limiting step in cartilage destruction. In arthritic lesions, collagenase-1 (matrix metalloproteinase-1) and collagenase-3 (matrix metalloproteinase-13) mediate the irreversible destruction of cartilage, suggesting that these enzymes are therapeutic targets. We describe the role of metalloproteinases in the destruction of connective tissues in arthritis and the treatment strategies that have been developed to block matrix metalloproteinases in an attempt to prevent this destruction. We also discuss novel compounds that may selectively inhibit these cartilage-degrading enzymes, providing opportunities to develop new therapeutic approaches.
The late Neoproterozoic Dahanib mafic-ultramafic intrusion, South eastern Desert, Egypt: Is it an Alaskan-type or a layered intrusion? (2017)

In Egypt, mafic-ultramafic complexes have been classified into three major types: incomplete ophiolite sequences; Alaskan-type intrusions, concentrically-zoned bodies formed in a subduction arc environment; and layered intrusions, vertically-zoned bodies intruded in post-collisional tectonic environments and rift-related bodies associated with the opening of the Red Sea. We present new field work, geochemical data, mineral chemistry and interpretations for the late Neoproterozoic Dahanib mafic-ultramafic intrusion in the South Eastern Desert of Egypt (northernmost Arabian--Nubian Shield, ANS). The Dahanib intrusion shows no evidence of metamorphism or deformation, with excellent preservation of intrusive contacts, well-preserved textures and primary mineralogy. Field relations indicate that it is younger than the surrounding metamorphic rocks and syn-tectonic granitoids. The intrusion is composed of a basal suite of ultramafic rocks (dunite, lherzolite, wehrlite and pyroxenite) and an overlying suite of mafic rocks (olivine gabbronorite, gabbronorite and anorthosite). It displays evident layering of modal abundance, visible directly in outcrop, as well as cryptic layering discernible through changes in mineral compositions. The western and eastern lobes of the Dahanib intrusion occur in the form of a lopolith with readily correlated layers, especially in the upper mafic unit. The present-day dip of the layering decreases from the ultramafic units into the mafic sequence. Structural and compositional relations show that the ultramafic units are cumulates from a high-Mg tholeiitic parent magma emplaced at deep crustal levels and evolved via fractional crystallization rather than any kind of residual mantle sequence. Fo content of olivine and Mg# of pyroxenes display a systematic decrease from ultramafic to mafic rocks, well-correlated with whole-rock Mg#. Spinels in ultramafic samples vary from Cr-rich to Al-rich and have Mg# and Fe^3+^\# similar to spinels from typical stratiform complexes and clearly different from those found in ophiolitic and Alaskan-type complexes. Although the mafic and ultramafic units are clearly related and can be derived from common parent magma, they were not emplaced coevally; rather, they represent different pulses of magma. The Dahanib mafic--ultramafic intrusion does not display any features that convincingly identify it as a typical Alaskan-type body, particularly the lack of clinopyroxenite and hornblendite, rarity of primary hornblende, and the notable abundance of orthopyroxene and plagioclase in its rocks. Our results confirm that it is more akin to a layered mafic-ultramafic intrusion with a multistage evolution. It was emplaced into a stable post-orogenic cratonic setting, with a trace element signature indicating contamination of the mantle source by previous subduction events.
ChemInform Abstract: Large Water‐Soluble Cyclophanes with Convergent Intracavity Functionality. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Studies on Coördination Compounds. III. The Chelating Tendencies of β-Diketones with the Chlorides of Copper(II), Nickel and Barium in Water—Dioxane Solutions (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on Coördination Compounds. III. The Chelating Tendencies of β-Diketones with the Chlorides of Copper(II), Nickel and Barium in Water—Dioxane SolutionsLeGrand G. Van Uitert, W. Conard Fernelius, and Bodie E. DouglasCite this: J. Am. Chem. Soc. 1953, 75, 2, 457–460Publication Date (Print):January 1, 1953Publication History Published online1 May 2002Published inissue 1 January 1953https://pubs.acs.org/doi/10.1021/ja01098a059https://doi.org/10.1021/ja01098a059research-articleACS PublicationsRequest reuse permissionsArticle Views142Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
RADIATION EFFECTS IN DIELECTRIC MATERIALS. (1968)

A model that explains observed polarization effects in insulators is proposed. A set of nonlinear partial differential equations applying to this model is given; this cannot in general be solved in closed form but may prove amenable to computer solution. The results of some sapphire irradiation experiments are presented showing the effect on polarization of different surface contact treatments. The results of conductivity measurements on different samples of sapphire show radiation-induced conductivity in Czochralski-grown single crystals to be approximately 2.5 times that in Verneuile-grown crystals. Also, results of proton-irradiation experiments on Mylar are presented and their applicability as a test of the van Lint-Nichols theory of ionization effects in irradiated dielectrics is discussed. A new formulation for the radiation-induced conductivity in insulators is presented which predicts a linear dependence on dose rate. Radiation experiments on polyethylene capacitor structures show a linear dependence of the prompt conductivity on dose rate over three orders of magnitude and show no dose dependence effect for a wide range of radiation pulse widths. (Author)
Secure Networking in the Sun Environment. (1986)

We present an authentication system that greatly improves the security of Sun&amp;apos;s network environment. The system uses DES encryption and public key cryptography to authenticate both users and machines in the network. The system is general enough to be used by other UNIX+ and non--UNIX systems. Introduction Sun&amp;apos;s Remote Procedure Call (RPC) mechanism has proved to be a very powerful primitive for building network services. The most well--known of these services is the Network File System (NFS), a service that provides transparent file--sharing between heterogenous machine architectures and operating systems. The NFS is not without its shortcomings, however. Currently, an NFS server authenticates a file request by authenticating the machine making the request, not the user. On a system accessing files with the NFS, it is a simple matter of running the su command to impersonate the rightful owner of the file. But the security weaknesses of the NFS are nothing new. The familiar command rlo...
Improved Oral Anticoagulation After a Dietary Vitamin K–Guided Strategy (2009)

A vitamin K-guided management strategy to adjust long-term oral anticoagulation is feasible and safe and may result in an increased chance of reaching target levels of INR.