gebhart/patrepeval huggingface dataset:
Correction to Role of Glutathione Transferases in the Mechanism of Brostallicin Activation (2010)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Role of Glutathione Transferases in the Mechanism of Brostallicin ActivationSilvia Pezzola, Giovanni Antonini, Cristina Geroni, Italo Beria, Maristella Colombo, Massimo Broggini, Sergio Marchini, Nicola Mongelli, Loris Leboffe, Robert MacArthur, Alessia Francesca Mozzi, Giorgio Federici, and Anna Maria Caccuri*Cite this: Biochemistry 2010, 49, 23, 4930Publication Date (Web):May 18, 2010Publication History Received12 May 2010Published online18 May 2010Published inissue 15 June 2010https://pubs.acs.org/doi/10.1021/bi100755ehttps://doi.org/10.1021/bi100755ecorrectionACS PublicationsCopyright © 2010 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views322Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (556 KB) Get e-AlertscloseSUBJECTS:Antioxidants,Cancer,Peptides and proteins Get e-Alerts
Physiological characterization of human muscle acetylcholine receptors from ALS patients (2011)

Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of motor neurons leading to muscle paralysis. Research in transgenic mice suggests that the muscle actively contributes to the disease onset, but such studies are difficult to pursue in humans and in vitro models would represent a good starting point. In this work we show that tiny amounts of muscle from ALS or from control denervated muscle, obtained by needle biopsy, are amenable to functional characterization by two different technical approaches: "microtransplantation" of muscle membranes into Xenopus oocytes and culture of myogenic satellite cells. Acetylcholine (ACh)-evoked currents and unitary events were characterized in oocytes and multinucleated myotubes. We found that ALS acetylcholine receptors (AChRs) retain their native physiological characteristics, being activated by ACh and nicotine and blocked by α-bungarotoxin (α-BuTX), d-tubocurarine (dTC), and galantamine. The reversal potential of ACh-evoked currents and the unitary channel behavior were also typical of normal muscle AChRs. Interestingly, in oocytes injected with muscle membranes derived from ALS patients, the AChRs showed a significant decrease in ACh affinity, compared with denervated controls. Finally, riluzole, the only drug currently used against ALS, reduced, in a dose-dependent manner, the ACh-evoked currents, indicating that its action remains to be fully characterized. The two methods described here will be important tools for elucidating the role of muscle in ALS pathogenesis and for developing drugs to counter the effects of this disease.
Preparation of Layered Double Hydroxide Microspheres by Spray Drying (2008)

In order to fully exploit their attractive properties in actual practical applications, layered double hydroxide (LDH) materials should be fabricated into macroscopic form. A magnesium−aluminum layered double hydroxide (MgAl-LDH) containing interlayer carbonate anions has been obtained using a synthesis route involving separate nucleation and aging steps, and microspheres of the material formed in a subsequent spray drying process. The resulting products are composed of nanosized LDH particles aggregated into solid microspheres with a diameter of 10−50 μm, a sphericity of 0.84, modal pore access diameter of 87.9 nm, surface area of 43 m2/g, and total pore volume of 1.29 cm3/g. The presence of an accessible diffusion pathway in the macropore domain of the LDH microspheres offers the possibility of enhanced performances in a wide range of applications. Furthermore, the spherical morphology of the materials was retained when the LDHs were converted into solid base catalysts by calcination and subsequent rehydration, indicating the robust nature of the macroscopic particles.
Abstract 2602: Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signaling. (2013)

Abstract Objective: Bone marrow-derived mesenchymal stem cells (BM-MSC) migrate to primary tumors and drive tumor progression. This study aimed to identify the molecular mechanisms associated with these heterotypic cellular interactions and analyse their relevance in colorectal cancer (CRC). Design: Paracrine interactions of BM-MSC with CRC cells were studied using collagen invasion assays, cell counts, flow cytometric cell-cycle analysis and tumor xenograft models. The role of neuregulin 1 (NRG1) and the human epidermal growth factor receptor (HER) family pathways were investigated using tyrosine kinase assays, mass spectrometry, pharmacological inhibition, antibody-mediated neutralisation and RNA interference. Transmembrane NRG1 (tNRG1), HER2 and HER3 expression was analysed in primary CRCs (n = 54), adjacent normal colorectal tissues (n = 4), liver metastases (n = 3) and adjacent normal liver tissues (n = 3) by immunohistochemistry. Results: BM-MSC stimulate invasion, survival and tumorigenesis of CRCs through release of soluble NRG1, activating the HER2/HER3-dependent PI3K/AKT signaling cascade in CRC cells. Tumor-associated mesenchymal cells (T-MC) in CRCs demonstrate high tNRG1 expression. HER2 and HER3 show membrane localization in cancer cells of CRC tissue. High tNRG1 expression in T-MC is significantly associated with advanced UICC stage (P = .005) and invasion depth (P = .04) and decreased 5-year progression-free-survival (PFS) (P = .01). Conclusion: Paracrine NRG1/HER3 signals initiated by BM-MSC promote CRC cell progression, and high tNRG1 expression is associated with poor prognosis. Citation Format: Olivier De Wever, Astrid De Boeck, An Hendrix, Hannelore Denys, Geert Braems, Marc Bracke. Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signaling. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2602. doi:10.1158/1538-7445.AM2013-2602
The Clinical Frailty Scale can indicate prognosis and care requirements on discharge in oncology and haemato‐oncology inpatients: A cohort study (2022)

A total of 676 patients were included in the study. Levels of frailty were high (Median CFS 6, 81.8% scored ≥5) and CFS correlated with performance status (R = 0.13: P = 0.047). Patients who were frail (CFS ≥ 5) were less likely to be discharged home (62.9%) compared with those who were not classed as frail (86.1%) (OR 3.6 [95%CI 2.1 to 6.3]: P < 0.001). Higher CFS was significantly associated with poorer prognosis in all ages. Solid organ malignancy (hazard ratio [HR] 2.60 [95%CI 2.05-3.32]) and CFS (HR 1.43 [95%CI 1.29-1.59]; P < 0.001) were independently associated with poorer survival. This study demonstrated that CFS may help predict prognosis in adult oncology inpatients of any age. This may aid informed shared decision-making in this setting. Future work should establish if routine CFS measurement can aid the appropriate prescription of systemic therapy and enable early conversations about discharge planning.
The detection and recognition of arrow markings recognition based on monocular vision (2009)

Road information understanding is a necessary task for both intelligent vehicles and driving assistance systems. Previous research mostly focused on the detection of lane position. Other information provided by arrow markings was scarcely mentioned. In this paper, Arrow extraction is carried out by projection histogram on Inverse perspective image and an arrow markings recognition algorithm is presented based on multi-class support vector machines. An improved Haar wavelet feature extraction approach is utilized to describe the feature of arrow markings. In order to guarantee generalization performance, the F-score method is used for feature reduction. The results show that the algorithm can detect and recognize arrow markings effectively, and it's robust to occlusion by other vehicles or poor visibility.
Ambient Layer‐by‐Layer ZnO Assembly for Highly Efficient Polymer Bulk Heterojunction Solar Cells (2015)

The use of metal oxide interlayers in polymer solar cells has great potential because metal oxides are abundant, thermally stable, and can be used in flexible devices. Here, a layer‐by‐layer (LbL) protocol is reported as a facile, room‐temperature, solution‐processed method to prepare electron transport layers from commercial ZnO nanoparticles and polyacrylic acid (PAA) with a controlled and tunable porous structure, which provides large interfacial contacts with the active layer. Applying the LbL approach to bulk heterojunction polymer solar cells with an optimized ZnO layer thickness of ≈25 nm yields solar cell power‐conversion efficiencies (PCEs) of ≈6%, exceeding the efficiency of amorphous ZnO interlayers formed by conventional sputtering methods. Interestingly, annealing the ZnO/PAA interlayers in nitrogen and air environments in the range of 60–300 °C reduces the device PCEs by almost 20% to 50%, indicating the importance of conformational changes inherent to the PAA polymer in the LbL‐deposited films to solar cell performance. This protocol suggests a new fabrication method for solution‐processed polymer solar cell devices that does not require postprocessing thermal annealing treatments and that is applicable to flexible devices printed on plastic substrates.
Sustained Zero‐Order Release of Intact Ultra‐Stable Drug‐Loaded Liposomes from an Implantable Nanochannel Delivery System (2013)

Metronomic chemotherapy supports the idea that long-term, sustained, constant administration of chemotherapeutics, currently not achievable, could be effective against numerous cancers. Particularly appealing are liposomal formulations, used to solubilize hydrophobic therapeutics and minimize side effects, while extending drug circulation time and enabling passive targeting. As liposome alone cannot survive in circulation beyond 48 h, sustaining their constant plasma level for many days is a challenge. To address this, we develop, as a proof of concept, an implantable nanochannel delivery system and ultra-stable PEGylated lapatinib-loaded liposomes, and we demonstrate the release of intact vesicles for over 18 d. Further, we investigate intravasation kinetics of subcutaneously delivered liposomes and verify their biological activity post nanochannel release on BT474 breast cancer cells. The key innovation of this work is the combination of two nanotechnologies to exploit the synergistic effect of liposomes, demonstrated as passive-targeting vectors and nanofluidics to maintain therapeutic constant plasma levels. In principle, this approach could maximize efficacy of metronomic treatments.
Do Preterm Infants Perceive Temporal Synchrony? An Analysis with the Eye-Tracking System (2017)

The aim of this study was to investigate auditory–visual temporal asynchrony in preterm infants using a habituation procedure coupled with an eye-tracking system in order to examine visual behavior accurately and determine specific visual areas of interest. Sixteen term infants, twelve low-risk near-term (LBW) preterm infants and eight Very Low Birth Weight (VLBW) preterm infants were tested at four months post term. Infants were habituated with an auditory–visual synchronic situation: a visual ball bounced back in synchrony with an auditory sound. In the test phase, an asynchronized situation and a synchronized situation were presented alternately three times. The results showed that VLBW infants spent more time looking at the target before being habituated compared to LBW preterm infants and full-term infants. Specific areas of interest showed that VLBW infants spent less time on the target than LBW and full-term infants and had a more heterogeneous visual exploration. Nevertheless, VLBW infants had the same novelty reaction as the other infant groups. Moreover, the study of areas of interest revealed that whatever the age group, infants looked more at the area where the sound was produced during the asynchronized trial. This result suggests that infants perceive asynchrony. We suggest that VLBW preterm infants show the same ability to habituate and novelty recovery through an early learning experience due to earlier additional extra-uterine exposure.
Last-Minute Bidding and the Rules for Ending Second-Price Auctions: Evidence from eBay and Amazon Auctions on the Internet (2002)

Last-Minute Bidding and the Rules for Ending Second-Price Auctions: Evidence from eBay and Amazon Auctions on the Internet by Alvin E. Roth and Axel Ockenfels. Published in volume 92, issue 4, pages 1093-1103 of American Economic Review, September 2002
The Current Status of Haemoglobin-based Blood Substitutes (1997)

Haemoglobin-based red cell substitutes have recently passed a myriad of safety studies and are now undergoing efficacy evaluation. There are numerous potential benefits with use of these solutions: they are readily available and have a long shelf-life; do not require typing and cross-matching; are free of viral or bacterial contamination; lack the immunosuppressive effects of blood; and have a much lower viscosity than blood. One-third of the 10 million units of blood transfused in the United States each year is utilized in the emergency setting. Therefore, a safe, effective substitute for blood should have significant impact upon the way we resuscitate bleeding patients. In this article, the current status of the various haemoglobin-based red cell substitutes is reviewed.
Vinje, Aasmund Olavsson: Das sprachwissenschaftliche und literarische Werk (2020)

Am 18. Februar 1859 verabschiedete Vinje sich als Berichterstatter der dänischsprachigen Zeitschrift Drammens Tidende von seiner Leserschaft und verkündete, künftig nur noch auf norwegisch – d. h. im ‚landsmaal‘, dem späteren ‚nynorsk‘ – publizieren zu wollen, und zwar in seiner kurz zuvor gegründeten Zeitschrift Dølen. Als Anlass gab er an, dass es zu dem erhofften langsamen Wandel von der offiziellen dänischen Schriftsprache zu einem sich an der Mündlichkeit orientierten Norwegisch vermutlich niemals kommen werde. Hintergrund war die auch nach dem Anschluss Norwegens an Schweden von 1814 bestehende Dominanz der dänischen Sprache in allen Bereichen der Schriftlichkeit.
Experimental Medicine Study to Measure Immune Checkpoint Receptors PD‐1 and GITR Turnover Rates In Vivo in Humans (2020)

Development of monoclonal antibodies (mAbs) targeting immune-checkpoint receptors (IMRs) for the treatment of cancer is one of the most active areas of investment in the biopharmaceutical industry. A key decision in the clinical development of anti-IMR mAbs is dose selection. Dose selection can be challenging because the traditional oncology paradigm of administering the maximum tolerated dose is not applicable to anti-IMR mAbs. Instead, dose selection should be informed by the pharmacology of immune signaling. Engaging an IMR is a key initial step to triggering pharmacologic effects, and turnover (i.e., the rate of protein synthesis) of the IMR is a key property to determining the dose level needed to engage the IMR. Here, we applied the stable isotope labeling mass spectrometry technique using <sup>13</sup> C<sub>6</sub> -leucine to measure the in vivo turnover rates of IMRs in humans. The <sup>13</sup> C<sub>6</sub> -leucine was administered to 10 study participants over 15 hours to measure <sup>13</sup> C<sub>6</sub> -leucine enrichment kinetics in 2 IMR targets that have been clinically pursued in oncology: GITR and PD-1. We report the first measurements of GITR and PD-1 median half-lives associated with turnover to be 55.6 and ≥ 49.5 hours, respectively. The approach outlined here can be applied to other IMRs and, more generally, to protein targets.
A Comparative Study of online P2P Lending in the USA andChina (2012)

Peer-to-Peer (P2P) lending provides online users an innovative loaning and investment vehicle without the intermediation of financial institutions. However, the research on online P2P lending is still scarce. In this study we review relevant literature and conduct a comparative study of online P2P lending practices in the USA and China. We find that two categories of credit information, “hard” and “soft” information, may have profound influences on lending outcomes in both countries, but lenders in China is more reliable on “soft” information. This study provides valuable insights for future research and practices and enriches the understanding of online P2P lending across countries.
Free Radicals and Antioxidants: Opportunities for Enhancing Treatment of Epilepsy with Personalized Medicine (2020)

Introduction: Epileptic seizures and antiepileptic drugs (AEDs) are a source of oxygen stress. Oxygen stress can have negative effects. These effects which can be prevented are largely unknown in clinical epileptology. Objective: The objective of the study is to discuss (a) homeostatic oxidant, antioxidant imbalance due to epileptic seizures and AEDs, (b) the protective factors that help prevent oxygen stress (OS), and personalized medicine based on pharmacogenomics and diet as therapeutic challenges in epilepsy. Discussion: Experimental models of epileptic seizures evoked by various means suggest that seizures can cause neuronal destruction. This is accompanied by an increased activity of free radicals and a reduction of total antioxidant capacity (in red blood cells, blood serum, and cerebrospinal fluid). A number of antioxidants have been found to attenuate the negative effects of OS and act neuroprotectively if they are administered prior to seizure occurrence: vitamins (C, E), trace elements (Se, Zn), melatonin, erdosteine, or natural herbal extracts. New AEDs (GBP, LEV, LTG, and TGB) cause no, or very little, OS as opposed to other drugs (CBZ, PHT, PB, VPA, TPM, or OXC), which have pronounced albeit heterogeneous and dose-dependent effects. It is suggested that AEDs should be administered together with free radical sweepers (vitamins, trace elements, electrolytes, melatonin) and other anti-oxidizing substances. Conclusions: (1) Epileptic seizures and AEDs cause OS. The effects vary greatly depending, among other things, on the daily drug dose. (2) The findings of research using a variety of seizure models are more unequivocal than the findings of research on patients with epilepsy. This suggests that the relations among seizures, AEDs, OS etiology, and OS consequences are complex. (3) Since existing AEDs cause OS, it is necessary to develop a new approach to AED treatment. (4) It is important to know the patient’s specific characteristics, including previous history, lifestyle, age, gender, weight, diet, environment, etc. They can be valuable tools to improve the quality of life of a person suffering from epilepsy. This concept of managing the patient health is called targeted medicine or personalized medicine.
Translational research strategy: an essential approach to fight the spread of antimicrobial resistance (2014)

Translation research strategy in infectious diseases, combining the results from basic research with patient-orientated research, aims to bridge the gap between laboratory findings and clinical infectious disease practice to improve disease management. In an era of increasing antimicrobial resistance, there are four main areas of clinical and scientific uncertainty that need to be urgently addressed by translational research: (i) early diagnosis of antibiotic-resistant infections and the appropriateness of empirical antibiotic therapy; (ii) the identification of reservoirs of antibiotic-resistant pathogens; (iii) the development of new antibiotics with lower propensities to evoke resistance; and (iv) the development of new non-antibiotic drugs to be used in the prevention of the spread of resistant bacterial strains. Strict European collaboration among major stakeholders is therefore essential. Appropriate educational tools to train a new generation of scientists with regard to a multifaceted approach to antimicrobial resistance research should be developed. Key areas include the support and implementation of European networks focused on translational research and related education activities, making potential therapeutics more attractive to investors and helping academic investigators to determine whether new molecules can be developed with clinical applicability.
Extrahippocampal Contributions to Age Differences in Human Spatial Navigation (2006)

The hippocampus (HC) and associated neural structures are hypothesized to contribute to individual differences in human spatial navigation. However, functional imaging studies and theoretical models underscore the importance of extrahippocampal regions as well. The purpose of the present study was to examine age differences in virtual environment navigation and to assess possible relationships between navigation and structural integrity of hippocampal and extrahippocampal brain regions. Healthy adult volunteers completed a virtual navigation task and underwent magnetic resonance imaging to assess volumes of the caudate nucleus (CN), cerebellum, HC, prefrontal, and primary visual cortices. Results demonstrated robust age-related differences in place learning. Moreover, individual differences in regional brain volumes as well as performance on the tests of memory and executive functions contributed to age differences in human place learning. High performance in a virtual navigation task was associated with larger volume of the CN and prefrontal gray and white matter. Larger hippocampal volume was associated with improved performance in the young but not old participants. We conclude that human navigation requires both hippocampal and extrahippocampal brain systems and draws on executive resources for successful performance.
Site-induced differences in spontaneous metastasis of MO4 mouse fibrosarcoma cells. (1985)

MO4 mouse fibrosarcoma cells metastasized to the lungs and to the regional lymph nodes from a subcutaneous tumour in the pinna when they were derived from a tumour in the tail or from lung metastases. In contrast, no metastases were found when MO4 cells were derived from a tumour in the pinna or from the parent cell line. Cells from tumours in the pinna produced metastatic tumours when they were implanted in the tail but not in the pinna. The type of implant-spheroidal cell aggregate, freshly cut tumour fragment or precultured tumour fragment- had no influence on the metastatic behaviour of the resulting tumour. These observations confirm the concept that local factors at the growth site of a tumour influence the metastatic behaviour of that tumour.