gebhart/patrepeval huggingface dataset:
Experimental Verification of Self-Adapting Data-Driven Controllers in Active Distribution Grids (2021)

Lately, data-driven algorithms have been proposed to design local controls for Distributed Generators (DGs) that can emulate the optimal behaviour without any need for communication or centralised control. The design is based on historical data, advanced off-line optimization techniques and machine learning methods, and has shown great potential when the operating conditions are similar to the training data. However, safety issues arise when the real-time conditions start to drift away from the training set, leading to the need for online self-adapting algorithms and experimental verification of data-driven controllers. In this paper, we propose an online self-adapting algorithm that adjusts the DG controls to tackle local power quality issues. Furthermore, we provide experimental verification of the data-driven controllers through power Hardware-in-the-Loop experiments using an industrial inverter. The results presented for a low-voltage distribution network show that data-driven schemes can emulate the optimal behaviour and the online modification scheme can mitigate local power quality issues.
A coarse-grained red blood cell membrane model to study stomatocyte-discocyte-echinocyte morphologies (2019)

An improved red blood cell (RBC) membrane model is developed based on the bilayer coupling model (BCM) to accurately predict the complete sequence of stomatocyte-discocyte-echinocyte (SDE) transformation of a RBC. The coarse-grained (CG)-RBC membrane model is proposed to predict the minimum energy configuration of the RBC from the competition between lipid-bilayer bending resistance and cytoskeletal shear resistance under given reference constraints. In addition to the conventional membrane surface area, cell volume and bilayer-leaflet-area-difference constraints, a new constraint: total-membrane-curvature is proposed in the model to better predict RBC shapes in agreement with experimental observations. A quantitative evaluation of several cellular measurements including length, thickness and shape factor, is performed for the first time, between CG-RBC model predicted and three-dimensional (3D) confocal microscopy imaging generated RBC shapes at equivalent reference constraints. The validated CG-RBC membrane model is then employed to investigate the effect of reduced cell volume and elastic length scale on SDE transformation, to evaluate the RBC deformability during SDE transformation, and to identify the most probable RBC cytoskeletal reference state. The CG-RBC membrane model can predict the SDE shape behaviour under diverse shape-transforming scenarios, in-vitro RBC storage, microvascular circulation and flow through microfluidic devices.
Micro-electronic monitoring of functional appliance wear (1990)

Measurement of actual bionator wear has so far been confined to a few studies involving only small samples. In this study a micro-electronic timing device was used in a greater number of patients (53 children) after the system proved to be reliable in a pretest involving 18 subjects. The patients were 9-14 years of age and had a timing device fitted in their bionators over a period of 3-6 months. The data were read from the memory chip at the regular treatment sessions every 3-4 weeks. There was evidence that the patients averaged 7.65 hours per day of wear, thus fulfilling only 50-60 per cent of the orthodontist's requirements. Further details and implications of the measurements are discussed.
A uniform constraint-based framework for the verification of infinite state systems (2000)

Automatic verification of infinite state systems is an important area of research. Unlike its finite state counterpart, in spite of the existence of a large body of theoretical and practical results on automatic verification of infinite state systems, there does not exist a uniform framework that is applicable to a large class of systems and that facilitates description of procedures that solves the verification problem for infinite state systems in practice as well as providing tools for reasoning about the termination conditions of such procedures. The purpose of this dissertation is to provide a uniform framework that (1) allows description of infinite state systems at their own level of granularity, (2) allows specifying their properties at a high level, (3) allows description of procedures, that can solve in practice the verification problems for infinite state systems, in a declarative fashion, (4) provides tools to reason about the termination conditions for such procedures, (5) facilitates derivation of abstractions for verification as well as easy incorporation of optimization techniques, (6) allows clear separation of the logical aspects of verification from the combinatorial ones, (7) allows combination of deductive (proof-theoretic) methods with model-theoretic ones and (8) provides, for free, data structures for implicit representation of possibly infinite sets of states.
Design of CRH axle temperature alarm based on digital potentiometer (2016)

To solve the test problems of alarm module used for CRH axle temperature monitoring system of the CRRC Qingdao Sifang CO. LTD., this paper analyzed the limitations of traditional debugging method (heating the temperature sensor area with a hot-air gun): long time for heating up, low efficiency. This paper takes the digital potentiometer as the temperature compensation component. We can change the equivalent resistance of PT100 temperature sensor by setting the temperature parameters of system manually through the touch screen and MCU, to simulate the axel temperature rising. Therefore the performance of the new axle temperature monitoring system can be verified through action of the alarm and the emergency brake. The original physical heating mode is replaced by the non-destructive embedded method which completes the test of alarm function of the axle temperature monitoring system.
Fabrication of periodic arrays of needle-like Si nanowires on (001)Si and their enhanced field emission characteristics (2017)

We report here the fabrication and field emission properties of highly-ordered, vertically-aligned tapered Si nanostructure arrays on (001)Si.
Genome-wide analysis ofin vivoTRF1 binding to chromatin restricts its location exclusively to telomeric repeats (2014)

Telomeres are nucleoprotein structures at the ends of eukaryotic chromosomes that protect them from degradation, end-to-end fusions, and fragility. In mammals, telomeres are composed of TTAGGG tandem repeats bound by a protein complex called shelterin, which has fundamental roles in the regulation of telomere protection and length. The telomeric repeat binding factor 1 (TERF1 or TRF1) is one of the components of shelterin and has been shown to be essential for telomere protection. Telomeric repeats can also be found throughout the genome, as Internal or Interstitial Telomeric Sequences (ITSs). Some of the components of shelterin have been described to bind to ITSs as well as other extra-telomeric regions, which in the case of RAP1 exert a key role in transcriptional regulation. Here, we set to address whether TRF1 can be found at extra-telomeric sites both under normal conditions and upon induction of telomere shortening. In particular, we performed a ChIP-sequencing technique to map TRF1 binding sites in MEFs wild-type and deficient for the telomerase RNA component (Terc(-/-)), with increasingly short telomeres. Our findings indicate that TRF1 is exclusively located at telomeres both under normal conditions, as well as under extreme telomere shortening. These results indicate that in mice not all members of shelterin have extra-telomeric roles as it was described for RAP1.
Existing dopaminergic therapies for Parkinson’s disease (2006)

Parkinson’s disease (PD) is a progressive neurological disorder associated with a gradual loss of dopamine neurons in the substantia nigra pars compacta, resulting in diminishing production of dopamine and loss of motor function. Although the aetiology of PD is not understood completely, the recent understanding of the cause of this disease from genetic mutations and the development of a chemical model have provided much deeper insight into the pathogenesis of the disease process. Over the years many different therapeutic agents have been developed to alleviate symptomatic problems in PD. Among these agent, dopaminergic therapy still plays a dominant role as a mainstay treatment agents. In this article, along with levo-dopa (L-dopa), a brief review on different dopamine receptor agonists has been presented. In addition, indirect dopaminergic agents, such as selective monoamine oxidase-B inhibitors and catechol-O-methyltransferase inhibitors, have also been included in the description.
Modeling Rett Syndrome Using Human Induced Pluripotent Stem Cells (2016)

Rett syndrome (RTT) is one of a group of neurodevelopmental disorders typically characterized by deficits in the X-linked gene MECP2 (methyl-CpG binding protein 2). The MECP2 gene encodes a multifunctional protein involved in transcriptional repression, transcriptional activation, chromatin remodeling, and RNA splicing. Genetic deletion of Mecp2 in mice revealed neuronal disabilities including RTT-like phenotypes and provided an excellent platform for understanding the pathogenesis of RTT. So far, there are no effective pharmacological treatments for RTT because the role of MECP2 in RTT is incompletely understood. Recently, human induced pluripotent stem cell (hiPSC) technologies have improved our knowledge of neurological and neurodevelopmental diseases including RTT because neurons derived from RTT-hiPSCs can be used for disease modeling to understand RTT phenotypes and to perform high throughput pharmaceutical drug screening. In this review, we provide an overview of RTT, including MeCP2 function and mouse models of RTT. In addition, we introduce recent advances in disease modeling of RTT using hiPSC-derived neural cells.
Cluster analysis of genetic variants enables reclassification of Crohn’s disease at the molecular level (2009)

peer reviewed
Investigation on the electrochemistry and cytotoxicity of the natural product marcanine A and its synthetic derivatives (2015)

The electrochemistry and cytotoxicity of marcanine A were investigated by electrochemical, computational and cellular studies.
Passenger Flow Predictions at Sydney International Airport: A Data-Driven Queuing Approach (2015)

Time spent in processing zones at an airport are an important part of the passenger's airport experience. It undercuts the time spent in the rest of the airport, and therefore the revenue that could be generated from shopping and dining. It can also result in passengers missing flights and connections, which has significant operational repercussions. Inadequate staffing levels are often to blame for large congestion at an airport. In this paper, we present a stochastic simulation that estimates the operational uncertainty in passenger processing at immigration. Congestion and delays are estimated on arrivals and departures based on scheduled flight departures and arrivals. We demonstrate the use of cellular tracking data in refining the model, and an approach to controlling congestion by adjusting staffing levels.
Transitions de Phase en Series Mesogenes: (1983)

Abstract The polymorphism of the di(4-alkylphenyl) and di(4-alkoxyphenyl) tetrathiafulvalene (TTF) is investigated by optical, crystallographic and calorimetric methods. All the studied derivatives are mesomorphic. The first mesophase is always a smectic G phase; the second one is a nematic N phase for short chains and a smectic C phase for long chains. The entropies corresponding to the passage high-temperature crystalline phase C1 → SG and to the “melting” (C1 → mesophases → isotropic phase I) increase with the length of the chain and with the presence of the oxygen atom in the radical.
Melt viscoelasticity of polypropylenes prepared under different polymerization regimes (2002)

Four samples of polypropylene (PP) prepared under different polymerization regimes were characterized by wide-angle (WAXS) and small-angle (SAXS) x-ray diffraction, by specific heat capacity in the temperature interval from −50 to 220°C (DSC), and by linear viscoelasticity at several fixed temperatures in the interval from 120 to 220°C. Storage G′(ω) and loss G″(ω) shear moduli in the melt state (measured in the frequency window spanning about three decades) were treated to derive the relaxation times spectra h(τ) using the nlreg computer program based on Tikhonov's method of nonlinear regularization. Molecular characteristics were derived from the melt viscoelastic properties of three crystallizable (isotacticity index above 95%) PP samples exhibiting Newtonian melt flow behavior at low angular frequencies. The anomalous viscoelastic behavior in the first heating run of the elastomeric PP in the temperature interval below ca. 170°C, combined with the relevant WAXS, SAXS, and DSC data, was considered as an evidence for the existence of a spatial network of microcrystallites formed by lateral aggregation of stereoregular sequences which were, however, too short for the development of chain-folded, lamellar crystals typical for semi-crystalline homopolymers. The “normal” viscoelastic behavior during the subsequent cooling run from a structureless melt state suggested a very slow kinetics of microcrystallinity development. The results obtained demonstrate a high potential of viscoelastic measurements for structural characterization of poorly crystallizable, elastomeric polymers.
Abstract 13573: Baseline TG/HDL Predicts Future Type 2 Diabetes in a 12-year Follow up of Mexican Americans in Starr County, TX: 2002-2014 (2017)

Introduction: The ratio of plasma triglycerides (TG) to HDL_cholesterol (HDL) was introduced as a tool to identify apparently healthy individuals at increased cardio-metabolic and diabetes risk. Th...
Herringbone structured thin films of alkyl-substituted pentacenes and FET performance (2009)

We have studied alkyl-substituted pentacene derivatives for solution-processing. By incorporation of substituent(s), enhancement of solubility depending on substituted position(s) and substituent(s) was confirmed. Solution-processed films of the derivatives showed highly oriented crystals with herringbone structure. This indicates that molecular aggregation and electronic structure have been preserved after the substitution as expected from molecular design. Thinfilm transistors of the derivatives exhibited large carrier mobility above 1cm<sup>2</sup>/Vs.
A novel rearrangement of trans-tetrahydroabietic acid in sulphuric acid (1974)

B. E. Cross, M. R. Firth and R. E. Markwell, J. Chem. Soc., Chem. Commun., 1974, 930 DOI: 10.1039/C39740000930
Adubação nitrogenada aplicada em cobertura na cultura do trigo na região Sudoeste do Paraná (2011)

A adubacao nitrogenada em trigo e recomendada por especialistas para aumentar a produtividade, dentre as fontes de nitrogenio destaca-se a ureia. O presente trabalho teve como objetivo avaliar o efeito de diferentes doses de nitrogenio em cobertura para a cultura do trigo na regiao de Planalto, PR. A cultivar utilizada foi BRS 220 em sistema de semeadura direta com espacamento entre linhas de 0,17cm obtendo uma densidade de 350 plantas por m². O delineamento utilizado foi o de blocos casualizados, compostos por 5 tratamentos com 4 parcelas e cada parcela foi constituida por uma area de 25,5 m², sendo 10m x 2,55m. Na adubacao de base foi utilizado 320 kg ha¹ do adubo formulado 08-20-20 utilizando uma fonte amidica de nitrogenio. Os tratamentos foram de 0, 30, 60, 90 e 120 kg ha¹ de N (ureia). Foram avaliadas a altura de plantas, tamanho de espigas, produtividade, peso do hectolitro e massa de 1000 graos. A aplicacao de nitrogenio feita em cobertura influencia significativamente na altura de planta, peso de 100 graos, Peso hectolitro e produtividade do trigo.
Dual liquid crystal alignment configuration based on nanoparticle-doped polymer films (2011)

This paper proposes an approach for producing dual liquid crystal (LC) alignment configuration based on nanoparticle-doped polymer films. Experimental results indicate that illuminating a nanoparticle-doped pre-polymer film, coated onto a substrate with a homogeneous alignment layer, with unpolarized UV light through a photomask causes the polymerization of pre-polymer, ultimately generating homogeneous and vertical alignment layers in unpolymerized and polymerized regions, respectively. The dual LC alignment configuration of the homogeneous (vertical) and hybrid alignments can be achieved by combining the treated substrate with another substrate that has a homogeneous (vertical) alignment layer. Additionally, the applications of the dual LC alignment layer in phase gratings and transflective LC displays are demonstrated.
Improvement in fresh fruit and vegetable logistics quality: berry logistics field studies (2014)

Shelf life of fresh fruits and vegetables is greatly influenced by environmental conditions. Increasing temperature usually results in accelerated loss of quality and shelf-life reduction, which is not physically visible until too late in the supply chain to adjust logistics to match shelf life. A blackberry study showed that temperatures inside pallets varied significantly and 57% of the berries arriving at the packinghouse did not have enough remaining shelf life for the longest supply routes. Yet, the advanced shelf-life loss was not physically visible. Some of those pallets would be sent on longer supply routes than necessary, creating avoidable waste. Other studies showed that variable pre-cooling at the centre of pallets resulted in physically invisible uneven shelf life. We have shown that using simple temperature measurements much waste can be avoided using 'first expiring first out'. Results from our studies showed that shelf-life prediction should not be based on a single quality factor as, depending on the temperature history, the quality attribute that limits shelf life may vary. Finally, methods to use air temperature to predict product temperature for highest shelf-life prediction accuracy in the absence of individual sensors for each monitored product have been developed. Our results show a significant reduction of up to 98% in the root-mean-square-error difference between the product temperature and air temperature when advanced estimation methods are used.
Grid Power-Delay Tradeoff for Energy Harvesting Wireless Communication Systems with Finite Renewable Energy Storage (2015)

In this paper, we study the grid power-delay tradeoff in a point-to-point energy harvesting wireless communication system with finite energy storage capacity serving delay-sensitive applications. This communication system is powered by both grid and renewable power sources. First, we consider the average grid power consumption minimization subject to the data queue stability and renewable energy availability constraints. By exploring the optimality property and using the theory of random walks, we transform the grid power minimization problem to an asymptotically equivalent problem. Using the Lyapunov drift approach, we obtain an online dynamic power control policy to solve the asymptotically equivalent problem. Then, we introduce a novel analysis framework to study the grid power-delay tradeoff relationship of the online power control in the small delay regime. Specifically, using continuous-time approximation, dynamic programming and sample-path approach, we obtain bounds on the average delay and grid power consumption, which are asymptotically tight in the small delay regime. Based upon the derived closed-form expressions, we quantify the impacts of energy storage capacity and some other system parameters on the grid power-delay tradeoff.
Role of high tibial osteotomy in chronic injuries of posterior cruciate ligament and posterolateral corner (2010)

High tibial osteotomy (HTO) is a surgical procedure used to change the mechanical weight-bearing axis and alter the loads carried through the knee. Conventional indications for HTO are medial compartment osteoarthritis and varus malalignment of the knee causing pain and dysfunction. Traditionally, knee instability associated with varus thrust has been considered a contraindication. However, today the indications include patients with chronic ligament deficiencies and malalignment, because an HTO procedure can change not only the coronal but also the sagittal plane of the knee. The sagittal plane has generally been ignored in HTO literature, but its modification has a significant impact on biomechanics and joint stability. Indeed, decreased posterior tibial slope causes posterior tibia translation and helps the anterior cruciate ligament (ACL)-deficient knee. Vice versa, increased tibial slope causes anterior tibia translation and helps the posterior cruciate ligament (PCL)-deficient knee. A review of literature shows that soft tissue procedures alone are often unsatisfactory for chronic posterior instability if alignment is not corrected. Since limb alignment is the most important factor to consider in lower limb reconstructive surgery, diagnosis and treatment of limb malalignment should not be ignored in management of chronic ligamentous instabilities. This paper reviews the effects of chronic posterior instability and tibial slope alteration on knee and soft tissues, in addition to planning and surgical technique for chronic posterior and posterolateral instability with HTO.
Mutation detection using ENDO1: Application to disease diagnostics in humans and TILLING and Eco-TILLING in plants (2008)

We introduce a cost-effective tool based on a simplified purification protocol of a mismatch-specific and sensitive endonuclease, ENDO1. Especially, we report the successful applications of ENDO1 in mutation diagnostics in humans, fingerprinting of complex population of viruses, and in TILLING and Eco-TILLING in plants.
Hyperbaric Oxygen Therapy and Tissue Regeneration: A Literature Survey (2022)

By addressing the mechanisms involved in transcription, signaling, stress reaction, apoptosis and cell-death, cellular structure and cell-to-cell contacts, adhesion, migration as well as inflammation; HBO upregulates processes involved in repair while mechanisms perpetuating tissue damage are downregulated. Many experimental and clinical studies, respectively, cover wound healing, regeneration of neural tissue, of bone and cartilage, muscle, and cardiac tissue as well as intestinal barrier function. Following acute injury or in chronic healing problems HBO modulates proteins or molecules involved in inflammation, apoptosis, cell growth, neuro- and angiogenesis, scaffolding, perfusion, vascularization, and stem-cell mobilization, initiating repair by a variety of mechanisms, some of them based on the modulation of micro-RNAs. HBO affects the oxidative stress response via nuclear factor erythroid 2-related factor 2 (Nrf2) or c-Jun N-terminal peptide and downregulates inflammation by the modulation of high-mobility group protein B1 (HMGB-1), toll-like receptor 4 and 2 (TLR-4, TLR-2), nuclear factor kappa-B (NFκB), hypoxia-inducible factor (HIF-1α) and nitric oxide (NO•). HBO enhances stem-cell homeostasis via Wnt glycoproteins and mammalian target of rapamycin (mTOR) and improves cell repair, growth, and differentiation via the two latter but also by modulation of extracellular-signal regulated kinases (ERK) and the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) pathway. The HBO-induced downregulation of matrix metalloproteinases-2 and 9 (MMP-2/-9), rho-associated protein kinase (ROCK) and integrins improve healing by tissue remodeling. Interestingly, the action of HBO on single effector proteins or molecules may involve both up- or downregulation, respectively, depending on their initial level. This probably mirrors a generally stabilizing potential of HBO that tends to restore the physiological balance rather than enhancing or counteracting single mechanisms.
Bistability of Limit Cycles in a Free‐Running VCSEL (2013)

International audience