gebhart/patrepeval huggingface dataset:
Ear-Canal Reflectance, Umbo Velocity, and Tympanometry in Normal-Hearing Adults (2011)

This study has established a database of objective measurements of middle ear function (ECR, umbo velocity, tympanometry) in a population of strictly defined normal-hearing ears. These data will promote our understanding of normal middle ear function and will serve as a control for comparison to similar measurements made in pathological ears.
2PT177 Photo-induced proton transfer of Anabaena sensory rhodopsin(The 50th Annual Meeting of the Biophysical Society of Japan) (2012)

IncorporatedAssociation structure of the chromophore binding region.The N-tcrminal lacking PYP is also photoactive.These facts suggest that the N-terminal regjon ofPYP
The Synthesis of Isothiazoles. I. 3,5-Dichloro-4-isothiazolecarbonitrile and Its Derivatives (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of Isothiazoles. I. 3,5-Dichloro-4-isothiazolecarbonitrile and Its DerivativesW. R. HatchardCite this: J. Org. Chem. 1964, 29, 3, 660–665Publication Date (Print):March 1, 1964Publication History Published online1 May 2002Published inissue 1 March 1964https://doi.org/10.1021/jo01026a033RIGHTS & PERMISSIONSArticle Views1079Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (701 KB) Get e-Alerts Get e-Alerts
Comprehensive Evaluation of Distributed Power Quality Based on Improved Entropy Method (2018)

With distributed generation access to the grid, power quality problems become increasingly prominent. These problems can threaten the safe and stable operation of the power grid. This paper establishes a distributed power quality comprehensive evaluation system. The improved entropy method is used to weight the subjective evaluation value and the objective evaluation value, to perform comprehensive evaluation of the power quality of the distributed distribution network. The subjective evaluation is obtained by the improved analytic hierarchy process, and the objective evaluation value is obtained by efficiency evaluation of the distributed power quality data by super efficiency data envelopment analysis. The results show that the improved entropy method considers both subjective and objective factors, resulting in comprehensive evaluation results that are more comprehensive and objective.
Benefits and Challenges of Tabletop Peripheral Displays (2004)

People tend to gather around tables both for work and for recreation, making them a tempting space to present awareness information. We motivate the use of tables as ambient displays in ubiquitous computing spaces, and reflect on lessons learned from our experiences with the AmbienTable, a prototype tabletop peripheral display deployed in the iRoom.
Malignant astrocytoma in elderly patients (2013)

Current standard of care for elderly patients with malignant astrocytoma involves a treatment strategy based on the MGMT gene promoter methylation status. The role of combined radiotherapy and TMZ chemotherapy and a potential role for the addition of anti-VEGF therapy to radiotherapy are currently addressed in ongoing trials. The lack of favorable prognostic factors in tumor tissue might in part explain the poorer clinical outcome of elderly patients.
Some Organosilicon Compounds Derived from Phenyl Ether (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Organosilicon Compounds Derived from Phenyl EtherHENRY GILMAN and DAVID MILESCite this: J. Org. Chem. 1958, 23, 9, 1363–1365Publication Date (Print):September 1, 1958Publication History Published online1 May 2002Published inissue 1 September 1958https://pubs.acs.org/doi/10.1021/jo01103a036https://doi.org/10.1021/jo01103a036research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Radiation chemistry of nucleotides: 8,5'-cyclonucleotide formation and phosphate release initiated by hydroxyl radical attack on adenosine monophosphates. (1976)

The formation of 8,5′-cycloadenosine 5′-monophosphate (8,5′-cycloAMP) in irradiated solutions of adenosine 5′-monophosphate (5′-AMP) has been quantified over the pH range 2-10. Maxima for G(8,5′-cy...
Atopic Dermatitis: One or Several Diseases? (2008)

Overview | The leading peer-reviewed scientific journal in contact dermatitis, and the only journal in its field that publishes leading research in atopic, contact, occupational, environmental, and drug dermatitis.
Stability in chemical and biological systems: Multistage polyenzymatic reactions (2010)

General principles of the theory of stability of solutions to differential equations are considered. The stability of equations describing the dynamics of changes in reagent concentrations in polyenzymatic biochemical chains is analyzed. Various mechanisms of formation of stable and unstable stationary states are considered, and unbalanced regimes and collapse are analyzed. The influence of systems of toxins and drugs on stability is studied. An interpretation of pathological processes based on stability theory is given.
As(III), As(V), Hg, and Pb Removal by Fe-Oxide Impregnated Activated Carbon (2000)

The removal of As(III), As(V), Hg(II), and Pb(II) by virgin and Fe(III) impregnated activated carbons (FeAC) was investigated. Iron-oxide impregnation increased the pHzpc of the carbon from 7.5 to about 8.2–8.7 but did not alter the surface area or the pore volume. The amount of acid or base needed to reach a given pH increased following impregnation, indicating that the FeAC was more active than its non-impregnated counterpart. Metal removal was a function of pH with removal increasing with pH for Hg(II) and Pb(II) and decreasing with pH for As(V). As(III) removal was not a strong function of pH below pH = 5, increased to a maximum at pH ≈ 7, then decreased with increasing pH. As(III) and As(V) removals were about one and two orders of magnitude higher, respectively, for the FeAC compared with the non-impregnated carbon, while Hg(II) and Pb(II) removals were only slightly higher. Fe-impregnation appears to be most effective for the anionic contaminants.
Topology and Membrane Association of Lecithin: Retinol Acyltransferase (2006)

Fatty acid retinyl esters are the storage form of vitamin A (all-trans-retinol) and serve as metabolic intermediates in the formation of the visual chromophore 11-cis-retinal. Lecithin:retinol acyltransferase (LRAT), the main enzyme responsible for retinyl ester formation, acts by transferring an acyl group from the sn-1 position of phosphatidylcholine to retinol. To define the membrane association and localization of LRAT, we produced an LRAT-specific monoclonal antibody, which we used to study enzyme partition under different experimental conditions. Furthermore, we examined the membrane topology of LRAT through an N-linked glycosylation scanning approach and protease protection assays. We show that LRAT is localized to the membrane of the endoplasmic reticulum (ER) and assumes a single membrane-spanning topology with an N-terminal cytoplasmic/C-terminal luminal orientation. In eukaryotic cells, the C-terminal transmembrane domain is essential for the activity and ER membrane targeting of LRAT. In contrast, the N-terminal hydrophobic region is not required for ER membrane targeting or enzymatic activity, and its amino acid sequence is not conserved in other species examined. We present experimental evidence of the topology and subcellular localization of LRAT, a critical enzyme in vitamin A metabolism.
Visit-to-visit variability of fasting plasma glucose as predictor of ischemic stroke: competing risk analysis in a national cohort of Taiwan Diabetes Study (2014)

Besides HbA1c, FPG-CV was a potent predictor of ischemic stroke in type 2 diabetic patients, suggesting that different therapeutic strategies now in use be rated for their potential to (1) minimize glucose fluctuations and (2) reduce HbA1c level in type 2 diabetic patients to prevent ischemic stroke.
Coded aperture subreflector array for high resolution radar imaging (2019)

This paper describes the design and demonstration of a 1024 element coded aperture subreflector array, implemented with single-bit phase shifters that utilize GaN HEMTs to modulate signals upon reflection. An active reflect-array enables digital beamforming using a single 235 GHz radar transceiver. Wafer level fabrication and assembly allows large arrays to be tiled up while maintaining reasonable costs.
Case-based Clinical Decision Support for Breast Magnetic Resonance Imaging (2013)

Breast cancer is the most common cancer (excluding skin cancer) and the second most frequent cause of cancer death among women in the United States. Dynamic contrast-enhanced MRI (DCE-MRI) screening is recommended as an adjunct for mammography for high-risk women and is increasingly used as a key staging tool for newly diagnosed breast cancer. Case-based clinical decision support (CDS) methods mimic natural physicians’ reasoning for diagnosis by reading similar cases that have been previously reviewed and diagnosed. A case-based CDS for breast lesion diagnosis may help physicians to decide whether a queried case is likely to be malignant or benign, thus avoiding misinterpretation and preventing unnecessary biopsies. Most of the case-based approaches in the published literature focus on breast cancer diagnosis based on mammogram and ultrasound images. Extending the case-based approach to DCE-MRI may improve the sensitivity and specificity. The challenge is to design an algorithm by taking more computer-calculated features into account to capture characteristics of malignant lesions. Additionally, there is also a challenge in obtaining the similarity relationship among cases for a case-based CDS system.
Laser resonators of a mirror and corner cube reflector: analysis by the imaging method (1984)

The modes of a laser cavity with a tilted corner cube reflector are simulated by the imaging method; the separate effects for both rotations of the corner cube and the mirror of the cavity are then studied.
Is comprehensive geriatric assessment hospital at home a cost-effective alternative to hospital admission for older people? (2021)

&lt;p&gt;&lt;strong&gt;Background&lt;/strong&gt;&lt;/p&gt;\nhospital level healthcare in the home guided by comprehensive geriatric assessment (CGA) might provide a less costly alternative to hospitalisation for older people.\n\n&lt;p&gt;&lt;strong&gt;Objective&lt;/strong&gt;&lt;/p&gt;\nto determine the cost-effectiveness of CGA admission avoidance hospital at home (HAH) compared with hospital admission.\n\n&lt;p&gt;&lt;strong&gt;Design/intervention&lt;/strong&gt;&lt;/p&gt;\na cost-effectiveness study alongside a randomised trial of CGA in an admission avoidance HAH setting, compared with admission to hospital.\n\n&lt;p&gt;&lt;strong&gt;Participants/setting&lt;/strong&gt;&lt;/p&gt;\nolder people considered for a hospital admission in nine locations across the UK were randomised using a 2:1 randomisation schedule to admission avoidance HAH with CGA (N = 700), or admission to hospital with CGA when available (N = 355).\n\n&lt;p&gt;&lt;strong&gt;Measurements&lt;/strong&gt;&lt;/p&gt;\nquality adjusted life years, resource use and costs at baseline and 6 months; incremental cost-effectiveness ratios were calculated. The main analysis used complete cases.\n\n&lt;p&gt;&lt;strong&gt;Results&lt;/strong&gt;&lt;/p&gt;\nadjusting for baseline covariates, HAH was less costly than admission to hospital from a health and social care perspective (mean −£2,265, 95% CI: −4,279 to −252), and remained less costly with the addition of informal care costs (mean difference −£2,840, 95% CI: −5,495 to −185). There was no difference in quality adjusted survival. Using multiple imputation for missing data, the mean difference in health and social care costs widened to −£2,458 (95% CI: −4,977 to 61) and societal costs remained significantly lower (−£3,083, 95% CI: −5,880 to −287). There was little change to quality adjusted survival.\n\n&lt;p&gt;&lt;strong&gt;Conclusions&lt;/strong&gt;&lt;/p&gt;\nCGA HAH is a cost-effective alternative to admission to hospital for selected older people.
Growth of high quality crack-free AlGaN films on GaN templates using plastic relaxation through buried cracks (2003)

A method is presented to achieve thick high quality crack-free AlGaN layers on GaN. This method uses jointly plastic relaxation and lateral growth. In a first step, plastic relaxation by cracking and misfit dislocation introduction is realized. Then the cracks are overgrown to obtain a smooth surface. By this reproducible technique, we grew smooth metal-organic chemical vapor deposition Al0.2Ga0.8N films with a threading dislocation density as low as 5×108 cm−2. This result is the best ever reported for crack-free AlGaN growth over a large area. The control of the complete plastic relaxation opens up perspectives for the realization of high performance devices. In order to explain the mechanisms involved in the full relaxation of the AlGaN/GaN heterostructure, we propose a relaxation scheme and discuss its different steps.
Microstructural analysis and oxidation protection behavior of Cr–Ni surface coatings of 347 stainless steel by rapid mirror scanning of a high power CO2 laser (2009)

A surface coating technique that uses a 1 kW CO2 laser beam actuated by two high-speed raster-scanning mirrors was utilized to selectively consolidate predeposited powder coatings consisting of 50%Cr-50% Ni (wt %) over the surface of 347 austenitic stainless steel specimens. The oxidation resistance of the coated samples was evaluated by heating them in air at 750 °C for up to 300 h. The migration behavior of the coating elements was studied. Comprehensive characterization of the samples was performed using scanning electron microscopy, energy dispersive spectrochemical analysis, and optical metallography. Surface protective coatings produced by this technique demonstrated a strong metallurgical bond with homogeneous dilution, low porosity, and uniform thickness. Metallographical analysis showed migration of coating species toward the bulk preferentially by means of grain boundary diffusion as a result of high-temperature exposure. Preliminary results from this study demonstrate that the surface modification by high-speed selective raster-scanning of a high-power laser beam is a versatile and expedient technique that could be used for applications that require large surface area coverage for oxidation protection.
Spray Interactions with Turbulence and Vortical Structures (2010)

The interactions of a spray with a turbulent gas flow is important in many applications (e.g., most power and propulsion applications). Two general types of studies exist. In one type, the global and statistical properties associated with a cloud or spray within a turbulent field are considered. In the other type, detailed attention is given to how individual particles behave in a turbulent or vortical field. Some studies consider both perspectives. Most of the research work in the field has been performed on the former type of study. Faeth (1987), Crowe et al. (1988), and Crowe et al. (1996) give helpful reviews of this type of research.
Frontispiece: Sustainable, Oxidative, and Metal‐Free Annulation (2017)

The urgency for the development of more sustainable and environmentally friendly reaction methodologies has been translated into increasing effort towards metal-free C−H bond functionalization. An annulation is considered as the most efficient strategy for the construction of cyclic molecules, since at least two new bonds a formed in a single step using acyclic coupling partners. Merging the benefits of both approaches allows the highly efficient synthesis of different important cyclic molecules from readily available and non prefunctionalized starting materials. New strategies and recent breakthroughs for the oxidative metal-free annulation via C−H bond functionalization are also highlighted in the Concept article by A. P. Antonchick et al. on page 10936 ff.
Induction of mu opioid and cannabinoid receptors by probiotics: A new mechanism of regulation of visceral pain perception (2007)

μ opioid receptor (MOR) and receptors for cannabinoids (CB1 and CB2), which belong to the G protein coupled receptor family, are expressed in the central nervous system where they exert analgesic effect. In the gut, they are especially expressed by epithelial cells and mediate analgesic effects. To evaluate the ability of different strains of probiotics 1) to induce MOR, CB1 and CB2 expression and 2) to regulate visceral pain perception by this mechanism. In vitro, colonic epithelial cells HT-29 were incubated for 0 to 6h with different strains of probiotics or bacteria (100 CFU/cell): L. acidophilus (NCFM), L. salivarius (UCC118), L. paracasei (Lpc 37), Bifidobacteria (BL04 and Bi07), a commensal E. coli, and an enteropathogenic E.coli (LF82) strain. The involvement of NF-κB activation on MOR and CB expression was assessed by comparing the effect of bacteria in wild-type mouse embryonic fibroblast (MEF p65+/+) or deleted for the p65 protein (MEF p65-/-). In vivo, Balb/c mice were orally fed with L. acidophilus NCFM (10e9 CFU) during 15 days. MOR and CB expression was evaluated in the colon of mice at the protein level by immunohistochemistry. The effect of NCFM (10e9 CFU) on visceral pain was investigated in a colorectal distension model (CRD) in rats having or not visceral hypersensitivity induced by butyrate instillation. By comparison with resting cells, NCFM (1±1 vs 145±65, p<0.01) and UCC118 (1±1 vs 28±8, p<0.01) were the most effective strains to induce rapidly a strong expression of MOR in epithelial cells. This induction was similar to the positive control consisting to HT-29 cells stimulated by optimal dosage of TNFα. Induction of CB1 (1±1 vs 3.7±0.8, p<0.05) and CB2 (1±1 vs 4.4±0.98, p<0.01) expression was limited to the NCFM strain. Other tested probiotic strains or bacteria did not affect MOR or CB expression. NCFM-induced MOR and CB expression was NF-κB dependent and only present in MEF p65+/+. In vivo, administration of NCFM in mice strongly enhanced colonic levels of MOR, CB1 and CB2. In rats, this strain decreased visceral perception allowing a 20% increase of physiological pain threshold. In animals with colonic hypersensitivity, NCFM administration increased by 44% the pain threshold, an effect equivalent to a subcutaneous injection of 1mg/kg morphine. L. acidophilus NCFM is the most effective strain to induce expression of MOR and CB in colonic epithelial cells. These findings suggest that modulation of the gut microbiota may regulate analgesia through the induction of MOR and CB expression, which may be used as new markers to screen functional bacterial strains with analgesic properties (patent applications FR04/09966-PCT EP05/010880).
KEMM: A Knowledge Engineering Methodology in the Medical Domain (2008)

Medical research and clinical practice deal with complex and heterogeneous data. This requires a systematic approach for semantic integration of information to support clinicians in their daily tasks.
Synthesis, structure, and properties of the complex [Cu(L)Cl] ∙ 2H2O (2016)

The crystal structure of copper(II) complex with the HL ligand obtained from 3-[4-carboxyphenylazo] penta-2,4-dione and ethylenediamine (En) was determined by X-ray diffraction. The crystals are orthorhombic: a = 7.329(3), b = 15.393(5), c = 18.474(7) Å, V = 2084.1(12) Å3, space group P212121, Z = 4, ρ(calcd.) = 1.486 g/cm3, R = 0.0441. The copper atom is coordinated by four nitrogen atoms of two En ligands and by the chlorine atom in an axial position according to the extended square pyramid geometry (4 + 1) (CIF file CCDC no. 1436882).
Virtual Deformation Control of the X-56A Model with Simulated Fiber Optic Sensors (2014)

A robust control law design methodology is presented to stabilize the X-56A model and command its wing shape. The X-56A was purposely designed to experience flutter modes in its flight envelope. The methodology introduces three phases: the controller design phase, the modal filter design phase, and the reference signal design phase. A mu-optimal controller is designed and made robust to speed and parameter variations. A conversion technique is presented for generating sensor strain modes from sensor deformation mode shapes. The sensor modes are utilized for modal filtering and simulating fiber optic sensors for feedback to the controller. To generate appropriate virtual deformation reference signals, rigid-body corrections are introduced to the deformation mode shapes. After successful completion of the phases, virtual deformation control is demonstrated. The wing is deformed and it is shown that angle-of-attack changes occur which could potentially be used to an advantage. The X-56A program must demonstrate active flutter suppression. It is shown that the virtual deformation controller can achieve active flutter suppression on the X-56A simulation model.