gebhart/patrepeval huggingface dataset:
Cnidicin, a Coumarin, from the Root of Angelica koreana, Inhibits the Degranulation of Mast Cell and the NO Generation in RAW 264.7 Cells (2001)

Cnidicin (1) and five related coumarins were isolated from the root extract of Angelica koreana (Umbelliferae) as active principles responsible for the inhibitory effect on the degranulation process of cultured mast cells. Cnidicin (1) demonstrated a significant inhibition upon the release of beta-hexosaminidase from the cultured RBL-2H3 cells in a dose dependent manner (IC50 value, 25 microM) and upon the nitric oxide production from the activated RAW264.7 cells (IC50 value, 7.5 microM). In agreement with this, cnidicin inhibited the expression of nitric oxide synthase in RAW264.7 cells.
Development and Validation of an Advanced Simulation Model for ORC-Based Systems (2012)

Low-grade heat recovery from solar or geothermal energy may be an eco-friendly resource for electric and thermal energy recovery. The Organic Rankine Cycle (ORC) is one of the main candidates to exploit low-temperature heat sources, otherwise difficult to access using conventional power generation systems. In this paper, an advanced thermodynamic model of an ORC is developed, with the final aim to optimize ORC conversion efficiency, especially for micro-CHP applications. First, a thorough review of issues related to ORC system modeling is presented by analyzing the state-of-the-art experience and advancements. Subsequently, an advanced simulation model is developed, by taking advantage of all the key characteristics of the models presented in the literature. The simulation model is developed in Matlab®/AMESim® environment, which allows system modeling both for steady and transient analysis. The heat source is coupled with the system through a plate heat exchanger, which is modeled using an iterative sub-heat exchanger modeling approach. A scroll expander, modeled in detail by decomposing the behavior of the fluid stream into several steps, is used to extract the useful work. Finally, model predictions for the evaporator and the expander are validated against both numerical and experimental data published in literature. The simulation model of the entire ORC system is also validated against literature data taken on a test bench.
Power Pulsation Decoupling in a Series-Stacked PV- Battery Inverter (2019)

This paper presents the design of an energy buffer decoupling double-line-frequency AC power pulsation from main DC power sources in the single-phase series-stacked PV-battery inverter. As the active decoupling technique reducing the amount of capacitance required to stabilize the DC-bus voltage and achieving elimination of electrolytic capacitors, the series-stacked buffer architecture is adopted. In this work, the focus is on the optimization of the buffer design in the series-stacked PV-battery inverter and presenting the control scheme of the partial-power DC-DC optimizer to avoid processing the double-line-frequency AC current through all the DC sources: a PV string and a battery. The steady-state operation of the AC power pulsation decoupling of the series-stacked PV-battery inverter is demonstrated and verified through the controller hardware-in-the-loop test.
The unrecognized prevalence of chronic kidney disease in diabetes (2005)

Undiagnosed CKD is common in diabetes. Current screening strategies, based on creatinine or albuminuria, fail to identify a considerable number of subjects with CKD. Incorporating eGFR into screening for CKD would identify individuals earlier in the natural history of the disease and enable early effective treatment to delay progression of CKD.
Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: results from the NIH-NHLBI-sponsored Women's Ischaemia Syndrome Evaluation (WISE) study (2005)

Among women undergoing coronary angiography for suspected myocardial ischaemia, PChP in women with no obstructive CAD predicted adverse CV outcomes. Such women might benefit from additional evaluation and aggressive risk factor modification therapy.
Relative Sensitivity and Specificity of Serodiagnostic Tests for Gluten-Sensitive Enteropathy (2020)

The occurrence of AGA and ARA has been compared in a few small groups of patients. With both IIF and ELISA tests Unsworth et al.5 and Volta et al.7 found a higher prevalence of AGA than of ARA in their dermatitis herpetiformis patients on a normal diet (Table 1). In contrast, Ljunghall et al.3 reported more ARA than AGA, i.e., anti-wheat grain antibodies, in their dermatitis herpetiformis patients. We examined ten children with dermatitis herpetiformis and found IgA-ARA in 90% and IgA-AGA in 30% of these patients.6 Later on we also compared the occurrence of AGA to that of EmA in 29 adult dermatitis herpetiformis patients on a normal diet. The frequency of IgA-class AGA was 59% and that of EmA 76%.4 These results, although based on a small group of dermatitis herpetiformis patients, suggest that ARA and EmA may be a better detector of dermatitis herpetiformis patients with mild jejunal damage. However, if we compare the antibody frequencies in patients with severe villous atrophy (SVA), the prevalences are not very different.1,2 Of our dermatitis herpetiformis patients with SVA, 12 (86%) had IgA-AGA, 13 (92%) had IgA-ARA, and 14 (100%) had IgA-EmA (Table 1). Further studies on a large group of patients are needed to confirm which of these tests has the best sensitivity and specificity in detecting dermatitis herpetiformis patients with small intestinal damage.138
Pre-hospital Resuscitation with HBOC-201 and rFVIIa Compared to HBOC-201 Alone in Uncontrolled Hemorrhagic Shock in Swine (2011)

In a previous dose escalation study our group found that combining 90μg/kg rFVIIa with HBOC-201 reduced blood loss and improved physiologic parameters compared to HBOC alone. In this follow-up study in a swine liver injury model, we found that while there were no adverse hematology effects and trends observed in the previous study were confirmed, statistical significance could not be reached. Additional pre-clinical studies are indicated to identify optimal components of a multifunctional blood substitute for clinical use in trauma.
Kerr effect in binary liquid mixtures (1986)

Measurements of the Kerr constant of several binary liquid mixtures are reported. Most of the cases do not show any additivity of the Kerr effect. The results are in qualitative agreement with a mean-field theory that takes into account the local-field corrections, with the only exception the water–lutidine mixture, which presents a consolution point near room temperature. The long-range concentration fluctuations due to the proximity of the critical point strongly influence the electric birefringence of the mixture.
Speeding up cardiac MR segmentation with semi-supervision: applications in cine imaging (2022)

Abstract Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): This material is based upon work supported by the Google Cloud Research Credits program with the award GCP19980904. Background Segmentation is an important postprocessing step in cardiac magnetic resonance (CMR) imaging that enables quantitative assessment of functional parameters. Deep learning can automate the segmentation process, producing accurate contours of cardiac structures while reducing the time required to analyze images and the interobserver variation compared to manual analysis. However, common approaches to training neural networks (NNs) require large amounts of labeled data, which is costly to generate and slows down the development of CMR segmentation NNs for new applications. Semi-supervision is an approach to alleviate this labeling burden by relying on abundant unlabeled data and a smaller amount of labeled data to train NNs. Purpose We propose a novel semi-supervised method to train CMR segmentation NNs. We use the proposed method to train NNs to segment the left ventricle in CMR cine images. Ultimately, we aim to show that semi-supervision can drastically reduce the amount of labeled data required to develop machine learning segmentation applications for CMR while maintaining high performance. Methods Our dataset consists of 1,208 short-axis cine CMR images and 1,244 long-axis cine CMR images. An expert annotator manually segmented the endocardium on the end-diastolic and end-systolic short-axis and long-axis images and the epicardium on the end-diastolic short-axis images. We split the dataset randomly by patient into 60% training, 20% validation, and 20% testing data. We train semi-supervised segmentation networks using a supervised cross-entropy loss to learn from the labeled training data and a cosine embedding loss in addition to a pseudo-labeling step to learn from the unlabeled training data. To evaluate how performance changes with different amounts of labeled training data, we vary the percent of training data that has labels from &amp;lt;1%-100%. We evaluate the predicted segmentation masks using the Dice coefficient. Results Using only 100 labeled image slices, the semi-supervised segmentation NNs achieve a mean Dice coefficient within 1.10% of networks trained with fully labeled training sets, corresponding to &amp;gt;85% reduction in required labeled training data (Table 1). The proposed semi-supervised method improves performance over naïve training by 6.21% for the most limited labeled data setting (i.e., 10 labeled image slices; Figure 1). Conclusion We have shown that NNs trained with limited labeled data achieve high performance on left ventricle segmentation in short-axis and long-axis CMR cines. The proposed approach is flexible and broadly applicable to different CMR segmentation tasks, enabling rapid development of segmentation networks for many cardiac structures and applications. Table 1Figure 1
The Sudan-born in Australia: A statistical profile (2011)

This article looks at the characteristics of the Sudan-born and compares the different waves of Sudanese flows to Australia. The Sudan-born are one of the fastest growing groups in Australia, numbering 1259 in 1991, rising to 2397 in 1996. By 2001, numbers had reached 4900. Sudan-born arrivals accelerated during the intercensal period 2001-06, with the population in Australia almost quadrupling to 19,049 in 2006.1 This acceleration was due to Australian government policy changes which resulted in entrants from Africa comprising a majority of the Humanitarian Program intake from 2003-04 to 2006-07, with the Sudanese dominating this flow.
The amino acid sequence analysis of the goat TNF--#alpha# mature peptide (2001)

The gene of the goat tumor necrosis factor (TNF#alpha#) have been cloned utilizing the polymerase chain reaction (PCR). The fragment (576bp) was cloned and sequenced. Then amino acid sequence of goat TNF#alpha# was deduced from the goat TNF#alpha# cDNA. The mature peptide of goat TNF-#alpha# contains 157 amino acids. Comparison goat to sheep, pig, human, mouse, the similarity of the amino acid sequence of TNF#alpha# was 98.1%, 86.0%, 81.5%, and 75.2%, respectively.
Extended Stability of Intravenous 0.9% Sodium Chloride Solution after Prolonged Heating or Cooling (2014)

A sterile intravenous solution of 0.9% sodium chloride that was heated or cooled remained stable and showed no signs of microbial or fungal growth for a period of 199 days. This finding will allow hospitals and emergency medical technicians to significantly extend the expiration date assigned to these fluids and therefore obviate the need to change out these fluids every 28 days as recommended by the manufacturer.
Interactive experience retrieval for a ubiquitous home (2006)

We present the current status of a system for continuous capture and retrieval of multimedia data from a home-like ubiquitous environment. A large number of cameras and microphones are used for video and audio acquisition. Pressure based sensors mounted on the house floor capture footsteps. The image and floor sensor data are analyzed further to add more functionality to a previously developed system. Basic image analysis is combined with interactive rank selection to identify significant events. A preliminary study is conducted on activity classification based on floor sensor data and we present the results. The system can be queried interactively based on date and time, location, persons, sounds and basic activity in terms of footsteps. After a brief discussion of the results and observations, the paper concludes with suggestions for possible future directions.
A study of phylloxera transcriptomes, comparing root and leaf feeding morphs (2013)

absent
Protease-activated receptor 1 is implicated in irritable bowel syndrome mediators–induced signaling to thoracic human sensory neurons (2018)

Proteases and protease-activated receptors (PARs) are major mediators involved in irritable bowel syndrome (IBS). Our objectives were to decipher the expression and functionality (calcium signaling) of PARs in human dorsal root ganglia (DRG) neurons and to define mechanisms involved in human sensory neuron signaling by IBS patient mediators. Human thoracic DRG were obtained from the national disease resource interchange. Expression of PAR1, PAR2, and PAR4 was assessed by immunohistochemistry and quantitative reverse transcription PCR (RT-qPCR) in whole DRG or in primary cultures of isolated neurons. Calcium signaling in response to PAR agonist peptides (PAR-AP), their inactive peptides (PAR-IP), thrombin (10 U/mL), supernatants from colonic biopsies of patients with IBS, or healthy controls, with or without PAR1 or PAR4 antagonist were studied in cultured human DRG neurons. PAR1, PAR2, and PAR4 were all expressed in human DRG, respectively, in 20%, 40%, and 40% of the sensory neurons. PAR1-AP increased intracellular calcium concentration in a dose-dependent manner. This increase was inhibited by PAR1 antagonism. By contrast, PAR2-AP, PAR4-AP, and PAR-IP did not cause calcium mobilization. PAR1-AP-induced calcium flux was significantly reduced by preincubation with PAR4-AP, but not with PAR2-AP. Thrombin increased calcium flux, which was inhibited by a PAR1 antagonist and increased by a PAR4 antagonist. Supernatants from colonic biopsies of patients with IBS induced calcium flux in human sensory neurons compared with healthy controls, and this induction was reversed by a PAR1 antagonist. Taken together, our results highlight that PAR1 antagonism should be investigated as a new therapeutic target for IBS symptoms.
Adenosine 2A Receptor agonists-induced tolerogenic dendritic cell protected kidney from ischemia/reperfusion injury (52.13) (2011)

Abstract NKT cell activation initiates the kidney ischemia/reperfusion injury (IRI) immune response. There are no effective treatments available on acute kidney injury (AKI) to date. DCs represent a new and promising immunotherapeutic approach for autoimmune diseases. Adenosine 2a receptor (A2aR) agonist, ATL313, protected kidney from IRI. We hypothesize that ATL313 programs DCs into tolerogenic DCs during a-galactosylceramide (aGC) priming in vitro, which protected the kidney from IRI by suppressing NKT cell activation. Both kidney pedicles were clamped in B6 mice for 24 mins and then released for 24 hrs. BMDCs were cultured and loaded with aGC(0.1nM) w or w/o ATL313(1nM). Cells were adoptively transferred to naive WT mice 2 days prior to the surgery. ATL313-treated aGC loaded WT DC (WT DC-aGC-ATL) significantly protected kidney IRI with lower plasma creatinine compared with DC-aGC control (P&amp;lt;0.001), which was not seen in A2aRKO DC-aGC-ATL treated mice (P&amp;gt;0.05). Mice receiving WT DC-aGC had significantly increased plasma IFN-g level (P&amp;lt;0.01), while mice receiving WT-DC-aGC-ATL had significantly lower level (P&amp;lt;0.01). ATL313 has no effect on CD1d/aGC complexes (L363) on DCs, but decreased IA, CD86 and CD40 expression on WT not A2aRKO DC-aGC. ATL313-induced tolerogenic DCs have increased IL-10 mRNA expression compared with DC-aGC (P&amp;lt;0.05). A2aR agonist-induced toerogenic DCs is a unique and potent cell-based strategy to attenuate IRI by blocking DC-NKT cell immunological synapses.
Mechanical and electrophysiological effects of protamine on isolated ventricular myocardium: evidence for calcium overload (1994)

The loss of the normal force-frequency relation, partial depolarisation, rise in resting tension, and appearance of rested state rapid cooling contractures suggest that unbound protamine can lead to excess intracellular Ca2+, mediated by an alteration in membrane ionic conductances.
Selective Coregulator Function and Restriction of Steroid Receptor Chromatin Occupancy by Hic-5 (2015)

Steroid receptors (SRs) bind specific DNA regulatory sequences, thereby activating and repressing gene expression. We previously showed that transcriptional coregulator Hic-5 facilitates glucocorticoid regulation of some genes but blocks glucocorticoid regulation of others. Here, in a genome-wide analysis, Hic-5 depletion dramatically increased the global number of sites occupied by glucocorticoid receptor (GR) α (the major GR isoform), and many binding sites blocked by Hic-5 were associated with genes for which Hic-5 also blocked glucocorticoid-regulated expression. Hic-5 had similar effects on GRγ (a splice variant of GRα) and estrogen receptor α (ERα), facilitating hormonal regulation of some genes and blocking hormonal regulation of others. As with GRα, Hic-5 blocking of hormonal gene regulation mediated by GRγ and ERα was associated with blocking of GRγ and ERα occupancy at nearby sites. Hic-5 supported hormonal regulation of many more genes for GRα than for GRγ or ERα and thus exhibited selective coregulator functions for different SRs. In contrast, the number of Hic-5-blocked genes was similar for all 3 SRs. In addition to classic coregulator activity, Hic-5 influences the genomic occupancy of multiple SRs and thereby blocks some aspects of hormonal regulation. Thus, Hic-5, because of its tissue-specific expression, could contribute to tissue-specific genomic occupancy and gene regulation by SRs.
PRELIMINARY SELECTION OF BASIC PARAMETERS OF DIFFERENT TORSIONAL VIBRATION DAMPERS INTENDED FOR USE IN MEDIUM-SPEED DIESEL ENGINES (2012)

In the development and application of highly dynamic mechanical systems, major problems can arise from usually unwanted accompanying processes, such as torsional vibrations. The internal combustion engine is a typical dynamic system with a high probability of fracture of a system part due to the effects of torsional vibrations. In engineering practice, the IC engine crankshaft fracture due to torsional vibrations is prevented by using additional devices that allow the transfer of critical vibration modes of the crankshaft out of the IC engine operating range, or devices damping the resulting twist angle amplitudes. This paper presents a possible approach to defining parameters of torsional oscillatory systems of IC engines needed for a preliminary selection of basic parameters of various types of torsional vibration dampers, such as the elastic damper, the balance weight damper and the dual mass flywheel. The proposed physical and mathematical models and methods of defining the input parameters were compared with experimental results.
Odd-bit triangular quadrature amplitude modulations (2009)

Adaptive modulation is a technique which alters constellation size depending on channel condition to achieve highspeed data transmission. However, the well-known modulation schemes transmitting odd bits per symbol, such as 8-ary phase shift keying (PSK) and cross quadrature amplitude modulation (cross QAM), are generally not considered as a candidate for the adaptive use due to their inherent power inefficiency. In this paper, we address three triangular quadrature amplitude modulations (TQAMs), i.e. regular, optimum and suboptimum TQAMs, to improve transmission efficiency for such odd-bit modulations. We suggest optimum and suboptimum bit stream mapping methods and a simple and optimum detection method for the proposed constellations. Analysis and simulation show that optimum and suboptimum TQAMs can provide the power gains of 1.80 dB and 1.64 dB over the conventional 8-ary PSK at a target symbol error rate of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> while maintaining low detection complexity.
Phosphofructokinase control in muscle: nature and reversal of pH-dependent ATP inhibition (1986)

The kinetic and regulatory properties of rabbit muscle phosphofructokinase (PFK:EC 2.7.1.11) have been reexamined in an attempt to clarify how the enzyme could achieve significant catalytic rates over the physiological pH range (down to 6.4). At 5.0 mM ATP, the apparent Km for fructose 6-phosphate (fructose 6-P) increases by at least 50-fold as the pH is decreased from 7.67 to 6.8 in 50 mM N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid-KOH buffer at 25 degrees C (7.50 to 6.63 at 37 degrees C). This effect can be nearly completely abolished in the presence of 10 microM fructose 2,6-bisphosphate (fructose 2,6-P2), with the greatest percentage change seen at low pH. In this case, the rabbit enzyme behaves as if the ATP concentration was low (1.0 mM) at any given pH. Conversely, at high ATP levels and a low pH of 6.8 at 25 degrees C, PFK behaves in the presence of fructose 2,6-P2 as if the pH has been increased to approximately 7.15 or a 0.35 pH unit shift at any given fructose 6-P concentration. At physiological concentration of fructose 6-P (0.1 mM), the positive effectors glucose 1,6-bisphosphate (glucose 1,6-P2) and either AMP, inorganic phosphate, or NH4+ were found to be, respectively, 60 and 40% as effective as fructose 2,6-P2 in reversing this pH-dependent ATP inhibition over the physiological pH range. In combination, however, glucose 1,6-P2 plus AMP were as effective as fructose 2,6-P2.(ABSTRACT TRUNCATED AT 250 WORDS)
Natural languages and the Chomsky hierarchy (1985)

The central claim of the paper is that NL stringsets are regular. Three independent arguments are offered in favor of this position: one based on parsimony considerations, one employing the McCullogh-Pitts (1943) model of neuruns, and a purely linguistic one. It is possible to derive explicit upper bounds for the number of (live) states in NL acceptors: the results show that finite state NL parsers can be implemented on present-day computers. The position of NL stringsets within the regular family is also investigated: it is proved that NLs are counter-free, but not locally testable.
S-Band EBID amplifier (1972)

A prototype microwave S-band amplifier utilizing Electron Beam Irradiated Diodes (EBID) has been built and evaluated. The amplifier consists of an electron beam forming and modulating structure, a high voltage accelerating region, a reverse bias silicon diode target section, and an output circuit. A helix was designed for optimum velocity modulation of the electron beam at a beam potential of 1 kv. The low beam velocity allows for a long interaction time in a relatively short helix. A subsequent post acceleration region provides a bombardment potential of 10 kv for the EBID diode. Hot test results of the EBID amplifier showed that the velocity modulation of the electron beam current was better than 80%.