gebhart/patrepeval huggingface dataset:
Oral immunotherapy for IgE ‐mediated cow's milk allergy: a systematic review and meta‐analysis (2011)

Cow's milk is a common cause of food allergy in children. Children usually outgrow cow's milk allergy by the age of 3-5 years, but some will have persistent symptoms beyond childhood. We performed a systematic review of randomized controlled trials (RCTs) and observational studies to assess the evidence supporting the use of oral immunotherapy in IgE-mediated cow's milk allergy to inform the World Allergy Organization guidelines. Of 1034 screened articles published until May 2011, five RCTs and five observational studies fulfilled a priori specified inclusion criteria. RCTs including 218 patients showed that oral immunotherapy, compared to elimination diet alone, increased the likelihood of achieving full tolerance of cow's milk [relative risk: 10.0 (95% CI: 4.1-24.2)]. Adverse effects of immunotherapy include frequent local symptoms (16% of doses), mild laryngospasm [relative risk: 12.9 (1.7-98.6)], mild asthma [rate ratio: 3.8 (2.9-5.0)], reactions requiring oral glucocorticosteroids [relative risk: 11.3 (2.7-46.5)] or intramuscular epinephrine injection [rate ratio 5.8 (1.6-21.9)]. Results of observational studies were consistent with those of RCTs. Despite the availability of RCTs, the overall low quality of evidence leaves important uncertainty about anticipated effects of immunotherapy due to very serious imprecision of the estimates of effects and the likelihood of publication bias for some of the critical outcomes. A potentially large benefit of oral immunotherapy in patients with cow's milk allergy may be counterbalanced by frequent and sometimes serious adverse effects. Additional, larger RCTs measuring all patient-important outcomes are still needed.
Treatment of Elderly Patients with Squamous Cell Carcinoma of the Head and Neck (2016)

The demographics of squamous cell carcinoma of the head and neck (SCCHN) is marked by a growing number of patients aged 65 and over, which is in line with global projections for other cancer types. In developed countries, more than half of new SCCHN cases are diagnosed in older people, and in 15 years from now, the proportion is expected to rise by more than 10%. Still, a high-level evidence-based consensus to guide the clinical decision process is strikingly lacking. The available data from retrospective studies and subset analyses of prospective trials suffer from a considerable underrepresentation of senior participants. The situation is even more challenging in the recurrent and/or metastatic setting, where usually only palliative measures are employed. Nevertheless, it is becoming clear that, if treated irrespective of chronological age, fit elderly patients in a good general condition and with a low burden of comorbidities may derive a similar survival advantage as their younger counterparts. Despite that, undertreatment represents a widespread phenomenon and, together with competing non-cancer mortality, is suggested to be an important cause of the worse treatment outcomes observed in this population. Due to physiological changes in drug metabolism occurring with advancing age, the major concerns relate to chemotherapy administration. In locally advanced SCCHN, concurrent chemoradiotherapy in patients over 70 years remains a point of controversy owing to its possibly higher toxicity and questionable benefit. However, accumulating evidence suggests that it should, indeed, be considered in selected cases when biological age is taken into account. Results from a randomized trial conducted in lung cancer showed that treatment selection based on a comprehensive geriatric assessment (CGA) significantly reduced toxicity. However, a CGA is time-consuming and not necessary for all patients. To overcome this hurdle, geriatric screening tools have been introduced to decide who needs such a full evaluation. Among the various screening instruments, G8 and Flemish version of the Triage Risk Screening Tool were prospectively verified and found to have prognostic value. We, therefore, conclude that also in SCCHN, the application of elderly specific prospective trials and integration of clinical practice-oriented assessment tools and predictive models should be promoted.
<title>Stress and temperature effects on the performance of polarization-maintaining fibers</title> (1990)

Three stress effects on the state of polarization in high birefringent polarization-maintaining fibers are reviewed. The stresses induced in PM fibers by the different thermal expansion coefficients between the stress-applying parts and the surrounding glass make stress-induced-birefringent fibers very sensitive to temperature variations. Mechanical perturbations can change the polarization state of PM fibers. Temperature changes can enhance any random microbends in wound optical fiber and cause mode coupling. The effect of periodic bends, small-radius bends, and twist and fiber individual crossing in the presence of transverse pressures on the degradation of the state of polarization rotation is investigated. A procedure for evaluating the performance of wound PM fibers in low temperature environments is also discussed.
Direct Assessment of Rabbit Cortical Bone Basic Multicellular Unit Longitudinal Erosion Rate: A 4D Synchrotron-Based Approach (2020)

Cortical bone remodeling is carried out by basic multicellular units (BMUs), which couple resorption to formation. Although fluorochrome labeling has facilitated study of BMU formative parameters since the 1960s, some resorptive parameters, including the longitudinal erosion rate (LER), have remained beyond reach of direct measurement. Indeed, our only insights into this spatiotemporal parameter of BMU behavior come from classical studies that indirectly inferred LER. Here, we demonstrate a 4D in vivo method to directly measure LER through in-line phase contrast synchrotron imaging. The tibias of rabbits (n = 15) dosed daily with parathyroid hormone were first imaged in vivo (synchrotron micro-CT; day 15) and then ex vivo 14 days later (conventional micro-CT; day 29). Mean LER assessed by landmarking the co-registered scans was 23.69 ± 1.73 μm/d. This novel approach holds great promise for the direct study of the spatiotemporal coordination of bone remodeling, its role in diseases such as osteoporosis, as well as related treatments. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Structural and electrochemical investigation of waste newspaper based electrodes for supercapacitor applications (2016)

Abstract There is a general consensus to develop renewable energy storage and conversion technologies to replace fossil fuel energy for sustainable development. Currently, the development of high performance energy storage and conversion devices is an important step on the road to alternative energy technologies. With a special focus on the upgradation of waste to valuable energy, this paper presents an effective synthetic method that utilizes waste newspapers as the precursor to prepare the activated carbon electrodes by the pyrolysis and chemical activation processes. The amorphous nature and surface morphology of the carbon samples were confirmed by XRD and SEM analysis, respectively. Activated waste newspaper carbon (AWNP) showed good electrochemical properties at 800 °C and its specific capacitance at a scan rate of 2 mV/s was found to be 380 F/g. It is important to mention that the source of the raw material is cost effective and suitable for green technology.
Využití akustické denzitometrie v hodnocení viability myokarduu nemocných s chronickou ischemickou chorobou srdeční (2003)

Sedmdesat nemocných s chronickou ischemickou chorobou srdecni
(ICHS) a dysfunkcnimi myokardialnimi segmenty bylo vysetřeno
akustickou densitometrii před planovanou revaskularizaci
myokardu. U 54 nemocných byla provedena revaskularizace alespoň
jedne tepny zasobujici dysfunkcni povodi. Těmto nemocným bylo v
průměrnem odstupu 3 měsiců po operaci nebo intervenci provedeno
kontrolni echokardiograficke vysetřeni se zaměřenim na funkci
revaskularizovaných, původně dyskinetických segmentů. Nalez z
tohoto vysetřeni byl považovan za referencni pro hodnoceni
využitelnosti akusticke densitometrie k diagnostice viability
myokardu. Byl použit 16 segmentarni model leve komory,
akusticka densitometrie byla hodnocena z vysetřeni v
parasternalni dlouhe ose, parasternalni kratke ose v urovni
papilarnich svalů mitralni chlopně a v apikalni ctyřdutinove a
dvoudutinove projekci. Z každeho segmentu byla hodnocena
maximalni amplituda cyklickeho kolisani integrovaneho zpětneho
rozptylu (CVIB - cyclic variation of integrated backscatter).
Ze ziskaných hodnot byla metodou Operacni křivky (ROC -
Receiver Operating Characteristic Curve) nalezena optimalni
hranicni hodnota pro rozliseni viabilniho a irreversibilně
postiženeho myokardu. Hranicni hodnoty CVIB pro anteroseptalni
segmenty, zadni stěnu, septum, lateralni stěnu, dolni stěnu,
předni stěnu a hrot jsou 4,1; 4,3; 4,4; 4,2; 4,5; 4,0 a 4,2 dB
(decibelů). Senzitivita densitometrie pro průkaz viabilniho
myokardu je při užiti těchto hranicnich hodnot 90,8%,
specificita 81,3%, positivni předpovědni hodnota 87,4% a
negativni předpovědni hodnota 86,1%.
Cardiac Troponin After Revascularization Procedures (2006)

A significant proportion (≈20%) of patients undergoing percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery develop elevated levels of creatine kinase MB isoform (CK-MB) afterward. Large increases in the concentration of CK-MB after PCI are associated with the risk of death, myocardial infarction, and repeat revascularization. However, the prognostic significance of modest elevations (less than five times the upper limit of normal [ULN]) after PCI remains controversial. It has been shown in some studies have shown that even minor elevations in CK or CKMB levels (more than one time the ULN) after PCI are associated with worse outcomes, but other studies have shown no association between small elevations in CK or CK-MB (less than five times the ULN) and recurrent cardiac events. Following CABG, almost all patients have elevated levels of CK-MB and the clinical significance is less well established. However, clinical studies show that large elevations (more than five times ULN) are associated with worse prognosis. Cardiac troponin is elevated more frequently after PCI and CABG. A number of procedure-related factors contribute to the rises in troponin, including unrecognized complications of PCI (distal embolization, minor side-branch occlusion), inflammation, direct cardiac manipulation, and direct current defibrillation during CABG. Although troponin levels are helpful in diagnosing periprocedural myonecrosis as well as predicting long-term outcomes, the optimal diagnostic and prognostic cutoff levels remain to be determined. Moreover, to date, the appropriate clinical response to these findings remains uncertain.
Purification and characterization of a hemolysin produced by Vibrio cholerae biotype El Tor: another toxic substance produced by cholera vibrios (1979)

A thermolabile direct hemolysin from an El Tor cholera vibrio strain has been isolated and partially characterized as a simple protein of ca. 20,000 molecular weight. In addition to its hemolytic activity, the hemolysin is cytotoxic, cardiotoxic, and rapidly lethal. In these respects it resembles the thermostable direct hemolysin/cytotoxin/cardiotoxin/lethal toxin of Vibrio parahaemolyticus and certain other bacterial hemolysins, although there are other significant differences. Because identical diseases are produced by both hemolytic and nonhemolytic cholera vibrios, the El Tor hemolysin may be presumed to be pathogenetically irrelevant. These observations raise the question of "When is a toxic substance also a toxin?"
An overview of gene therapy in head and neck cancer (2013)

Gene therapy is a new treatment modality in which new gene is introduced or existing gene is manipulated to cause cancer cell death or slow the growth of the tumor. In this review, we have discussed the different treatment approaches for cancer gene therapy; gene addition therapy, immunotherapy, gene therapy using oncolytic viruses, antisense ribonucleic acid (RNA) and RNA interference-based gene therapy. Clinical trials to date in head and neck cancer have shown evidence of gene transduction and expression, mediation of apoptosis and clinical response including pathological complete responses. The objective of this article is to provide an overview of the current available gene therapies for head and neck cancer.
Immunologic injury of cultured cells infected with measles virus. I. role of IfG antibody and the alternative complement pathway. (1975)

In these studies, a number of human cell lines including epithelial, neural, glial, and lymphoid cells infected with several strains of measles virus were found to be lysed upon incubation with fresh sera from humans containing antibody measles virus. In all instances, the cytolytic event was mediated by alternative complement (C) pathway without a significant contribution from classical pathway. In contrast, isolated measles virus in conjunction with antibody was found to selectively activate the classical C pathway. Measles antibodies of the IgG class, but not the IgA class, possessed cytolytic potential against cells infected with measles virus. Human IgG antibodies could directly activate the alternative C pathway. No defect was found in cytolytic measles antibody in sera or cerebrospinal fluid from patients with subacute sclerosing panencephalitis, nor was the alternative C pathway impaired in sera from these patients. Sera from newborn humans exhibited a functional alternative C pathway.
Current status of COREX technology and recent developments (2003)

The results achieved with the COREX plants presently in operation show that this technology is a true alternative to the conventional blast furnace. With the experience gained from these plants, continuing developments have been made for the COREX process itself (recycling of steel plant wastes and use of other raw materials), for the equipment design and in the area of investment costs and profitability.
A Criterion for the Crack Initiation in Reinforced Composite Materials with Dispersed Flat Inclusions (1982)

強化複合材の分散相からのき裂初生の解明は複合材の強度研究上不可欠である.本報告では,分散偏平介在物を有する強化複合材において偏平介在物先端における応力の特異性の強さに着目して偏平介在物先端からのき裂初生について検討した.偏平金属介在物を埋め込んだエポキシ樹脂試験片を作製し,光弾性試験および引張試験を行い偏平介在物先端からのき裂初生に関するクライテリオンを提案した.
Word similarity computation based on HowNet (2015)

Word similarity computation has important applications in many areas, such as natural language processing, intelligence information retrieval, document clustering, automatic answering, word sense disambiguation, machine translation etc. This article makes an intensive study of word similarity computation based on HowNet and the word similarity is computed in three steps: (1) computes sememes similarity, (2) computes concepts similarity using the weight sum method of sememes similarity, (3) takes the maximum similarity of concepts as words similarity. This article mainly introduces numbering the sememes and presents a more accurate method of decomposing the concept description type. The experiment shows that the algorithm of word similarity presented in this article is simple and feasible, and the computed results are relatively consistent with awareness.
Adenosine and adenosine analogues are more toxic to chronic lymphocytic leukemia than to normal lymphocytes (1983)

We compared the effect of adenosine and adenosine analogues on the phytohemagglutinin-induced proliferative response of blood lymphocytes from normal subjects and patients with chronic lymphocytic leukemia. As measured by the inhibition of thymidine or leucine incorporation, adenosine was more toxic to chronic lymphocytic leukemia (CLL) than to normal lymphocytes. This difference was not affected by the removal of adherent cells. The patients' B lymphocytes were more susceptible to adenosine toxicity than normal B lymphocytes. Similar responses were noted in T lymphocytes from both sources. Differential susceptibility was also observed with deoxyadenosine and adenosine analogues, including 5'deoxyadenosine. Uridine rescue from adenosine toxicity was observed for normal and CLL lymphocytes. In the presence of uridine, there was no difference in the residual inhibition of CLL as compared to normal lymphocytes. Intact CLL lymphocytes metabolized 14C-adenosine at a much lower rate than normal lymphocytes. While it appears that the greater toxicity of adenosine to CLL lymphocytes reflects the impaired catabolism of this nucleoside by these cells, evidence is presented that this is not the only mechanism underlying the differential susceptibility. These results may serve as the basis for further pharmacologic investigations of adenosine and adenosine deaminase inhibitors in chronic lymphocytic leukemia.
Real-time Phase Correction for High-SNR Fieldable Dual-Comb Spectroscopy (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text F. R. Giorgetta, G. Ycas, E. Baumann, G. Truong, K. C. Cossel, E. M. Waxman, I. Coddington, W. C. Swann, and N. R. Newbury, "Real-time Phase Correction for High-SNR Fieldable Dual-Comb Spectroscopy," in Light, Energy and the Environment, OSA Technical Digest (online) (Optica Publishing Group, 2016), paper FW2E.6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Cancer Stage Prediction Based on Patient Online Discourse (2010)

Forums and mailing lists dedicated to particular diseases are increasingly popular online. Automatically inferring the health status of a patient can be useful for both forum users and health researchers who study patients ’ online behaviors. In this paper, we focus on breast cancer forums and present a method to predict the stage of patients ’ cancers from their online discourse. We show that what the patients talk about (content-based features) and whom they interact with (social networkbased features) provide complementary cues to predicting cancer stage and can be leveraged for better prediction. Our methods are extendable and can be applied to other tasks of acquiring contextual information about online health forum participants. 1
HCTU and TCTU: New Coupling Reagents — Development and Industrial Aspects (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Exposure of neonates to Respiratory Syncytial Virus is critical in determining subsequent airway response in adults (2006)

Neonatal RSV exposure results in long term pulmonary inflammation and exacerbates allergic airways disease. The early increase in TNF-alpha in the bronchoalveolar lavage implicates this inflammatory cytokine in orchestrating these events. Finally, the data presented emphasize IL-13 and TNF-alpha as potential therapeutic targets for treating RSV induced-asthma.
Integrated measuring system for the detection of the revolutions of LIGA microturbines in view of a volumetric flow sensor (1992)

The authors have demonstrated that it is possible to detect the number of revolutions of the LIGA microturbines easily and with high accuracy using a fiber optical system. The main advantage is that the fibre is integrated in the microstructure level. The microturbines have been driven for nearly 100 million revolutions. So far flow rates from 10 sccm min-1 to 50 sccm min-1 have been detected. As there is also a defined correlation between the number of revolutions and the flux of the gas it seems possible to use these microturbines as volumetric flow sensors.
‘Click cyclic ADP-ribose’: a neutral second messenger mimic (2014)

Analogues of the potent Ca(2+) releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca(2+) release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators.
Neuronal membrane proteasomes regulate neuronal circuit activity in vivo and are required for learning-induced behavioral plasticity (2023)

Protein degradation is critical for brain function through processes that remain incompletely understood. Here, we investigated the in vivo function of the 20S neuronal membrane proteasome (NMP) in the brain of <i>Xenopus laevis</i> tadpoles. With biochemistry, immunohistochemistry, and electron microscopy, we demonstrated that NMPs are conserved in the tadpole brain and preferentially degrade neuronal activity-induced newly synthesized proteins in vivo. Using in vivo calcium imaging in the optic tectum, we showed that acute NMP inhibition rapidly increased spontaneous neuronal activity, resulting in hypersynchronization across tectal neurons. At the circuit level, inhibiting NMPs abolished learning-dependent improvement in visuomotor behavior in live animals and caused a significant deterioration in basal behavioral performance following visual training with enhanced visual experience. Our data provide in vivo characterization of NMP functions in the vertebrate nervous system and suggest that NMP-mediated degradation of activity-induced nascent proteins may serve as a homeostatic modulatory mechanism in neurons that is critical for regulating neuronal activity and experience-dependent circuit plasticity.
Analyse des structures et milieux continus (1994)

SOMMAIRE : 1e PARTIE : Connaissances de base et analyse elastique. 1.Contrainte et principe d'equivalence. 2.De l'essai de traction a quelques principes fondamentaux. 3.Notion de securite. 4.Traction et compression. 5.Flexion plane. 6.Flexion oblique et flexion composee. 7.Proprietes mecaniques des materiaux. 8.Torsion uniforme. 9.Contraintes dues a l'effort tranchant. 10.Deformee des poutres soumises a flexion simple. 11.Sollicitation composee - Cisaillement direct - Assemblages. 12.Principes des travaux virtuels et calcul des deplacements. 13.Energie. - DEUXIEME PARTIE : Plasticite et analyse limite. 14 : Traction plastique. 15.Flexion plastique plane. 16.Calcul de la charge limite des structures hyperstatiques simples. 17.Theoremes fondamentaux de l'analyse limite. 18.Flexion plastique composee et simple. 19.Torsion plastique uniforme. TROISIEME PARTIE : Instabilite par flambement. 20 : Flambement des poutres. 21.Flambement plan des pieces industrielles. 22.Instabilite energetique
La prestation compensatoire et les droits démembrés de propriété (2004)

International audience
Systematic audit of third-party android phones (2014)

Android has become the leading smartphone platform with hundreds of devices from various manufacturers available on the market today. All these phones closely resemble each other with similar hardware and software features. Manufacturers must therefore customize the official Android system to differentiate their devices. Unfortunately, such heavily customization by third-party manufacturers often leads to serious vulnerabilities that do not exist in the official Android system. In this paper, we propose a comparative approach to systematically audit software in third-party phones by comparing them side-by-side to the official system. Specifically, we first retrieve pre-loaded apps and libraries from the phone and build a matching base system from the Android open source project repository. We then compare corresponding apps and libraries for potential vulnerabilities. To facilitate this process, we have designed and implemented DexDiff, a system that can pinpoint fine structural differences between two Android binaries and also present the changes in their surrounding contexts. Our experiments show that DexDiff is efficient and scalable. For example, it spends less than two and half minutes to process two 16.5MB (in total) files. DexDiff is also able to reveal a new vulnerability and details of the invasive CIQ mobile intelligence software.