gebhart/patrepeval huggingface dataset:
A Convenient Synthesis of N4,O3′, O5′-Triacetyl-2′-Ketocytidine (1997)

Abstract A convenient synthesis of the title compound in four steps from cytidine is reported. Key transformations include differentiation of the 2′ position as N4,O3′,O5′-triacetyl-2,2′-anhydrocytidine, opening to the arabino derivative, and oxidation of the 2′ position with the Dess-Martin reagent.
Phase retrieval with sparsity priors and application to microscopy video reconstruction (2013)

International audience
Mapping lung tumor cell drug responses as a function of matrix context and genotype using cell microarrays (2016)

Carcinoma progression is influenced by interactions between epithelial tumor cells and components of their microenvironment. In particular, cell-extracellular matrix (ECM) interactions are known to drive tumor growth, metastatic potential, and sensitivity or resistance to therapy. Yet the intrinsic complexity of ECM composition within the tumor microenvironment remains a barrier to comprehensive investigation of these interactions. We present here a high-throughput cell microarray-based approach to study the impact of defined combinations of ECM proteins on tumor cell drug responses. Using this approach, we quantitatively evaluated the effects of 55 different ECM environments representing all single and two-factor combinations of 10 ECM proteins on the responses of lung adenocarcinoma cells to a selection of cancer-relevant small molecule drugs. This drug panel consisted of an alkylating agent and five receptor tyrosine kinase inhibitors. We further determined that expression of the neuroendocrine transcription factor ASCL1, which has been previously associated with poor patient outcome when co-expressed with the RET oncogene, altered cell responses to drugs and modulated cleavage of the pro-apoptotic protein caspase-3 depending on ECM context. Our results suggest that co-expression of specific ECM proteins with known genetic drivers in lung adenocarcinoma may impact therapeutic efficacy. Furthermore, this approach could be utilized to define the molecular mechanisms by which cell-matrix interactions drive drug resistance through integration with clinical cell samples and genomics data.
Separation and characterization of modified variants of recombinant human insulin-like growth factor I derived from a fusion protein secreted from Escherichia coli (1990)

Human insulin-like growth factor I, IGF-I, was produced in Escherichia coli fused to a synthetic IgG-binding peptide The fusion protein is secreted into the medium during fermentation and was initially purified on an IgG-Sepharose column. After hydroxylamine cleavage, IGF-I was purified to homogeneity. During purification, impurities in the form of modified variants of IGF-I were detected and characterized. The closely related impurities were identified to be a misfolded form of IGF-I, having mismatched disulphide bonds, a form with the single methionine residue in IGF-I oxidized to methionine sulphoxide and a variant in which the methionine residue was substituted by a norleucine residue during protein synthesis. A form proteolytically cleaved between two arginine residue was also detected. These impurities were separated from the major component, native IGF-I, by using reverse-phase h.p.l.c. The modified molecules as well as native IGF-I were characterized both as intact molecules and as fragments, after pepsin digestion, using the techniques of plasma desorption m.s., N-terminal sequencing and amino acid analysis. The oxidized form was 90%, and the norleucine analogue was 70%, as potent as native IGF-I in a biological radioreceptor assay, and the form having mismatched disulphides lacked receptor affinity.
Formation of fluorocarbon films by ultraviolet surface photopolymerization (1974)

The formation of surface-photopolymerized films from six fluorocarbon monomers in the gas phase at low pressure is described. Transparent, low surface-energy films from 250 to 300 Å thick readily formed on glass microscope slides on exposure to an UV source in the presence of the monomer vapor. These films were characterized by water and hydrocarbon contact angles and by surface analysis by x-ray photoelectron spectroscopy (XPS). Although these films strongly adhered to the surface under normal conditions, they could be removed by exposure to an oxygen plasma for a few minutes. Surface analysis by XPS revealed that the fluorocarbon was converted to fluoride ion by plasma treatment.
Pre-Exposure Chemoprophylaxis (PREP) as an HIV Prevention Strategy (2003)

Chemoprophylaxis may be a prevention strategy for the sexual transmission of human immunodeficiency virus (HIV). Evidence suggests that condom use has waned with the availability of antiretroviral medication, at least in some resource-rich settings. Barrier methods of HIV prevention have inherent problems, and the potential for failure. Microbicide research has focused primarily on male-to-female transmission. Analogous to post-exposure prophylaxis, HIV prevention may be achieved by pre-exposure prophylaxis in some settings. Research in this potential strategy may be rewarding.
Planar collimated illumination system using nano-hybrid low index materials (2011)

A nano hybrid organo silicate material system is successfully used to realize a planar area illumination system with a highly collimated light output.
Deficits in Heel-Rise Height and Achilles Tendon Elongation Occur in Patients Recovering From an Achilles Tendon Rupture (2012)

The side-to-side difference found in maximal heel-rise height can be explained by a difference in Achilles tendon length in patients recovering from an Achilles tendon rupture. Minimizing tendon elongation appears to be an important treatment goal when aiming for full return of function.
Stabilization of Ucon LB‐550‐X stationary phase film by hydrogen chloride (1987)

Abstract The influence of gaseous hydrogen chloride on the efficiency and thermal stability of a Ucon LB‐550‐X stationary phase film has been studied under various working conditions. The efficiency of capillary columns was found to be unchanged or even increased, and the upper working temperature increased by 40–50°C. Nor did the action of hydrogen chloride change the polarity of the columns studied.
Sudden Ionospheric Disturbance Grid. (1974)

The technique described will allow controllers to quickly determine (1) whether a short wave fade in progress will affect any of their hf circuits, (2) the degree to which each circuit is affected, (3) alternative frequencies, and (4) alternative traffic routes available. The only required input parameter is 1 - 8A X-ray flux. The computer program continuously displays the LOF over any number of preselected hf transmission paths in predictive, real-time, or historical mode. The technique was designed primarily for naval commands which control hf systems covering large geographical areas, such as Communication Area Management Sections at Navy Communications Stations and HF Direction Finding Net Control.
Commercial manufacturing practices applied to phased array radars (2010)

Transmit/Receive Modules for Phased Array Radar are often identified as a key cost driver for the system. The cost structure of the module is driven by both the performance specifications and the choices made in design and manufacturing of the module. Seeking a path to dramtically lower the cost of T/R modules for phased array systems, commercial processes and practices have been adopted for the MMIC design, MMIC packaging and module construction. These new manufacturing approaches offer a path to cost reduction while maintaining a high level of performance.
Possible Involvement of Retinylidene Phospholipid in (1974)

SUMMARY Rhodopsin regeneration from opsin and all-trons-retinal involves two discrete reactions: isomerization of all-transretinal to II-cr (b) 450- to 460~nm light is the most effective for isomerization; (c) the isomerizing activity of partially delipidated rod outer segments is restored by added phosphatidylethanolaine (phosphatidylcholine is without effect and phosphatidylserine is inhibitory); (d) phosphatidylethanolamine can form a complex with all-irans-retinal and is active in the isomerization reaction; and (e) treatment of rod outer segments with guanidine hydrochloride or trichloroacetic acid, extreme pH values (1 and 13), or heat completely denatures opsin protein but affects isomerizing activity only slightly. From these results, we conclude that the isomerizing activity of rod outer segments is not of enzymic nature but can be accounted for by formation of a protonated Schiff base between phosphatidylethanolamine and all-trans-retinal. Kinetic data suggest that about 30% of the phosphatidylethanolaine molecules associated with rod outer segments are involved in complex formation with all-frans-retinal and retinal remains in the complex after photoisomerization.
Endothelin Receptor Antagonists (2006)

In our effort to obtain antagonists of the ET receptors, rational design based on agonist structure played a crucial part in the strategy that led to SB 209670. In vivo pharmacological studies with SB 209670, both in our own laboratories and through the work of others, have done much to elucidate potential roles for ET in the etiology of disease and to establish the therapeutic potential of ET receptor antagonists. Hampered in our search for an orally effective agent by the poor bioavailability of SB 209670, intestinal permeability screening was used to discover SB 217242, an antagonist with excellent oral characteristics. The key contributions outlined above toward the design of SB 217242 emphasize the multi-disciplinary approach used in today’s drug discovery efforts.
Temperature and energy efficiency optimization in multi-phase induction heating systems (2013)

Multiphase induction heating is a powerful solution for industrial metal heating. An innovative and optimized combination of the supply currents which is presented in this paper, looks for improving the temperature profile. The resonant inverter and inductor losses of this given structure are calculated for each optimized solution and lead to a maximization of the efficiency.
Thymic Requirement for Clonal Deletion During T Cell Development (1989)

During T cell differentiation, self tolerance is established in part by the deletion of self-reactive T cells within the thymus (negative selection). The presence of T cell receptor (TCR)-alpha beta + T cells in older athymic (nu/nu) mice indicates that some T cells can also mature without thymic influence. Therefore, to determine whether the thymus is required for negative selection, TCR V beta expression was compared in athymic nu/nu mice and their congenic normal littermates. T cells expressing V beta 3 proteins are specific for minor lymphocyte stimulatory (Mlsc) determinants and are deleted intrathymically due to self tolerance in Mlsc+ mouse strains. Here it is shown that V beta 3+ T cells are deleted in Mlsc+ BALB/c nu/+ mice, but not in their BALB/c nu/nu littermates. Thus, the thymus is required for clonal deletion during T cell development.
Buck-Boost Type MPPT Circuit Suitable for Photovoltaic Generation of Vehicle Installation (2018)

This paper proposes a buck-boost type MPPT circuit suitable for photovoltaic generation of solar car. By using an analog circuit for MPPT control, high conversion efficiency and weight reduction could be achieved by an accurate maximum power point tracking of photovoltaic generation. In order to reduce power conversion loss on wide voltage variation of the battery, buck-boost type dc-dc converter is used as a main power converter of the MPPT circuit. The proposed MPPT circuit which led to 12 sets of series-parallel was used for the solar car named "2017 Tokai Challenger" for the race and confirmed advantageous photovoltaic power generation.
The significance of protein in food intake and body weight regulation (2003)

Protein is more satiating than carbohydrate and fat in the short term, over 24 h and in the long term. Thermogenesis plays a role in this satiety effect, but the role of satiety hormones still needs to be elucidated. On the short-term 'fast' proteins are more satiating than 'slow' proteins, and animal protein induces a higher thermogenesis than vegetable protein. In the longer term the higher postabsorptive satiety and thermogenesis are sustained irrespective of the protein source. High-protein diets affect body weight loss positively only under ad-libitum energy intake conditions, implying also a decreased energy intake. Body composition and metabolic profile are improved. Additional protein consumption results in a significantly lower body weight regain after weight loss, due to body composition, satiety, thermogenesis, and energy inefficiency, while the metabolic profile improves. Implications from these findings are: for practice, recommendations for increasing the percentage of energy from protein while reducing energy intake; for clinical research, assessment of the paradox of increasing the percentage energy from a highly satiating macronutrient; of the potential roles of protein in a negative and positive energy balance; assessment of possibilities of replacing dietary protein by effective amino acids or peptides that may show a similar impact on body weight regulation.
Update 1 of: Mass Accommodation and Chemical Reactions at Gas−Liquid Interfaces (2011)

ADVERTISEMENT RETURN TO ISSUEReviewNEXTUpdate 1 of: Mass Accommodation and Chemical Reactions at Gas−Liquid InterfacesPaul Davidovits*, Charles E. Kolb, Leah R. Williams, John T. Jayne, and Douglas R. WorsnopView Author Information Chemistry Department, 2609 Beacon Street, Boston College, Chestnut Hill, Massachusetts 02467, United States Center for Aerosol and Cloud Chemistry, Aerodyne Research, Inc., 45 Manning Road, Billerica, Massachusetts 01821, United States This is a Chemical Reviews Perennial Review. The root paper of this title was published in Chem. Rev.2006, 106 (4), 1323−1354, DOI: 10.1021.cr040366k; Published (Web) March 16, 2006. Updates to the text appear in red type.*Phone: 617-552-3617. Fax: 617-552-2705. E-mail: [email protected]Cite this: Chem. Rev. 2011, XXXX, XXX, XXX-XXXPublication Date (Web):April 13, 2011Publication History Received27 October 2010Published online13 April 2011Published inissue 13 April 2011https://pubs.acs.org/doi/10.1021/cr100360bhttps://doi.org/10.1021/cr100360breview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views2135Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aerosols,Cluster chemistry,Interfaces,Liquids,Molecules Get e-Alerts
Insulin-like growth factor-binding protein-3 gene -202 A/C polymorphism is correlated with advanced disease status in prostate cancer. (2003)

The circulating level of insulin-like growth factor-binding protein-3 (IGFBP-3) is inversely associated with the risk of prostate cancer (PCa) and its progression and may be modulated by the A/C polymorphism at position -202 in the promoter region of IGFBP-3. This study was conducted to evaluate the role of the A/C polymorphism as a genetic modifier in the etiology of PCa and its disease status. The polymorphism was analyzed by a PCR restriction fragment-length polymorphism technique in 307 PCa patients, 221 benign prostatic hyperplasia (BPH) patients, and 227 male controls. No significant difference in the genotype frequency was found between the PCa or BPH patients and controls (PCa versus control, P = 0.316; BPH versus control, P = 0.964). Regarding the tumor stage, the C allele was more frequently observed in patients having tumors with higher stage (P for trend = 0.002). When the PCa patients with localized disease (stage A + B + C) were considered as reference, those with CC and AC genotype had a significantly increased risk of metastatic disease (stage D) compared with those with AA genotype [age-adjusted odds ratio (aOR) = 3.89, 95% confidence interval (CI) = 1.42-10.64, P = 0.008, and aOR = 1.68, 95% CI = 1.01-2.79, P = 0.044, respectively]. The presence of the C allele appeared to be associated with an increased risk of metastatic PCa with a gene dosage effect (aOR = 1.82, 95% CI = 1.23-2.68, P = 0.002). Similarly, significant findings were also observed when PCa patients were compared between those with organ-confined disease (stage A + B) and those with extra-prostatic extension (stage C + D). Furthermore, the C allele was present more frequently in patients with higher tumor grade. In conclusion, the IGFBP-3 -202 A/C polymorphism was not associated with susceptibility to PCa and BPH in Japanese men, but the presence of the C allele may cumulatively increase the risk for tumor metastasis and for having tumors with a biologically more aggressive phenotype. Because of the significant differences in incidence of clinically evident PCa according to racial backgrounds, the conjecture should be further examined in different racial populations.
Adaptive Multi-Channels Allocation in LoRa Networks (2020)

In this paper, we consider an IoT dedicated network corresponding to a non licensed LoRa Low Power Wide Area Network. The LoRa network operates in the unlicensed 868 MHz band within a total bandwidth of 1 MHz divided into 8 orthogonal channels of 125 kHz each. Despite the high level of interference, this network offers long range communications in the order of 2 to 5 km in urban areas and 10 to 30 km in rural areas. To efficiently mitigate this high level of interference, LoRa network essentially relies on a Chirp Spread Spectrum (CSS) modulation and on repetition diversity mechanisms. The LoRa CSS modulation spreads the signal within a band of 125 kHz using 6 possible spreading factors (from 7 to 12) to target data rates (starting from 5 kbps for the closest node to 300 bps for the furthest ones). The repetition diversity mechanisms enable the data recovery when the transmission is subject to bad channel conditions or/and high interference levels. Although the CSS modulation protects edge-cell's devices from the high level of interference induced by nodes in the proximity of the gateway, it fails to protect nodes at the edge of a given SF region and several trials are required to recover the packet. In this paper, we propose an adaptive multi-channels allocation policy that attributes multiple adjacent channels of 125 kHz for nodes situated at the edge of SF zones. We study the impact of this adaptive sub-band allocation on the gateways' intensities, the rate distribution and the power consumption. Our results are based on a statistical characterization of the interference in the network as well as the outage probability in a typical cell.
A computer classification of psychiatric patients (1967)

A new numerical classification procedure and the results that were obtained when this procedure was applied to a group of psychiatric patients is discussed in this paper.
Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation (2011)

Recipient antigen-presenting cells (APCs) initiate GVHD by directly presenting host minor histocompatibility antigens (miHAs) to donor CD8 cells. However, later after transplantation, host APCs are replaced by donor APCs, and if pathogenic CD8 cells continue to require APC stimulation, then donor APCs must cross-present host miHAs. Consistent with this, CD8-mediated GVHD is reduced when donor APCs are MHC class I(-). To study cross-presentation, we used hosts that express defined MHC class I K(b)-restricted miHAs, crossed to K(b)-deficient backgrounds, such that these antigens cannot be directly presented. Cross-priming was surprisingly efficient, whether antigen was restricted to the hematopoietic or nonhematopoietic compartments. Cross-primed CD8 cells were cytolytic and produced IFN-γ. CD8 cells were exclusively primed by donor CD11c(+) cells, and optimal cross-priming required that they are stimulated by both type I IFNs and CD40L. In studying which donor APCs acquire host miHAs, we made the surprising discovery that there was a large-scale transfer of transmembrane proteins from irradiated hosts, including MHC class I-peptide complexes, to donor cells, including dendritic cells. Donor dendritic cells that acquired host MHC class I-peptide complexes were potent stimulators of peptide-specific T cells. These studies identify new therapeutic targets for GVHD treatment and a novel mechanism whereby donor APCs prime host-reactive T cells.
Effect of menopause and hormone replacement therapy on urinary excretion of pyridinium cross‐links: a longitudinal and cross‐sectional study (1992)

Urinary pyridinoline and deoxypyridinoline, new markers of bone resorption, remain fairly constant in the years before the menopause and start to increase about 6 months after the last menstrual bleeding. This increase is reversed by hormone replacement therapy.
Thermal and Mechanical Properties of Blends and Composites from HDPE and Date Pits Particles (2008)

The date pits flour was used as a filling material in composition with high density polyethylene (HDPE). The blending proportions were: (1) 10% date pits, 90% HDPE; (2) 20% date pits, 80% HDPE; (3) 30% date pits, 70% HDPE; and (4) 40% date pits, 60% HDPE. Thermal conductivities, specific heat, and melt flow index of the blends were determined. The thermal conductivities ranged from 0.460 to 0.720 W/(m°C) and specific heats ranged from 1.10 to 5.30 kJ/(kg°C). The tensile and flexural tests on composite plates, fabricated by compress molding, indicated that strength and strain values decreased with increase in the percentage of date pits. There was no significant difference between flexural moduli of elasticity of the composites, but tensile modulus had the highest value at 30% blend. Moduli of elasticity of the composites were lower than the plates prepared from virgin HDPE at 180°C. It was presumed that high temperature processing of pure HDPE altered its original properties and consequently increased its modulus of elasticity.