gebhart/patrepeval huggingface dataset:
Les mystères de la ruelle : la topique du lieu dans le roman précieux (2001)

L’espace privilégié de la ruelle, dès le sous-titre du roman de Michel de Pure, La Pretieuse ou les mystères de la ruelle (1656-1658), acquiert une importance primordiale dans la macrostructure du roman. Un locus amoenus isolé du monde extérieur, cet espace intime féminin devient rapidement une métonymie de la préciosité. La grosse majorité du roman se déroule dans une ruelle et rares sont les discussions des précieuses qui n’en font pas mention. L’accès à la ruelle ou la connaissance des act...
Nucleophilic character of acyl radicals. Absolute rate constant for the acylation of protonated benzothiazole by pivaloyl radical (1976)

The absolute rate consta-t for the addition of pivaloyl radical to protonated benzothiazole is determined by evaluating the ratio of decarbonylation and aromatic attack. The high rate constant (7.1 × 105 l mol–1 s–1 at 5 °C) is discussed in terms of polar effects and a divergence from the classical reactivity: selectivity relationship is suggeste
Improvements Over Drug Blood Levels: Implications from Computerized Math Models (1985)

The clinical use of the 24-hour average serum lithium level does not have the inconsistencies inherent in using the morning serum lithium level as a measure of body exposure to lithium. On a group of 32 inpatients the morning serum lithium level was seen to overlap just 37.2% with the 24-hour body exposure to lithium. This 24-hour average lithium level was found by computerized pharmacokinetic simulation implemented on a microcomputer. This simulation also yielded the renal lithium clearance and permitted prescription of doses based on forecasts of future serum lithium levels.
Atividade antitumoral de metabolitos bacteriano e fungico (2005)

Os potenciais imuno e quimioterapeutico de dois compostos, o imunomodulador agregado proteico de fosfolinoleato-palmitoleato de amonio e magnesio (P-MAPA) produzido por Aspergillus oryzae e o pigmento citotoxico violaceina, produzido pela Chromobacterium violaceum, foram avaliados neste trabalho. Para tanto, foram utilizados os modelos experimentais murinos do carcinoma renal (RENCA), tumor ascitico de Ehrlich (TAE), carcinoma pulmonar de Lewis (3LL) e linhagens de celulas endoteliais e da leucemia mielocitica humana (HL60). Resultados obtidos em experimentos in vivo sugeriram atividade antitumoral para a violaceina nas doses de 0,1 e 1,0 mg kg no modelo experimental do TAE, enquanto o composto P-MAPA, na dose de 5 mg kg, tambem apresentou atividade nos modelos RENCA e 3LL. Alem disso, observou-se uma reducao no numero de metastases pulmonares no grupo de animais inoculados com RENCA e tratados com P-MAPA apos a nefrectomia do rim contendo o tumor primario, indicando uma contribuicao do composto em protocolos de tratamento de doenca residual. Alguns aspectos dos mecanismos envolvidos nestas respostas tambem foram investigados pela analise de diferentes parâmetros celulares e moleculares in vitro e/ou in vivo como a inducao de apoptose, atividade de celulas natural killer e producao de citocinas. O estudo da citotoxicidade da violaceina em culturas de celulas RENCA, TAE e HL60 demonstrou a inducao de processo apoptotico como mecanismo de acao da droga. A apoptose foi estudada utilizando-se a reacao de Feulgen, determinacao de fragmentacao de DNA, avaliacao da atividade de caspases, ensaio de marcacao com Anexina V/PI, alteracoes na expressao da proteina Bcl-2 e no potencial transmembrana mitocondrial (Dy). O potencial antitumoral demonstrado nesta tese para os metabolitos estudados reforca a possibilidade de aplicacao na terapeutica contra o câncer, sendo ainda promissor considera-Ios em estudos futuros de terapia combinada.
Abstract
Caracteristica de secagem e calor especifico da curcuma (curcuma longa L.) (1997)

RESUMO: O conhecimento do calor especifico e das curvas de secagem de materiais biologicos e um ponto-chave nos projetos de equipamento e simulacao de secagem e resfriamento. Este trabalho teve como objetivo obter o calor especifico da curcuma e curvas de secagem. A curcuma foi cortada em fatias, tratada com vapor e submetida a secagem. As curvas de secagem foram determinadas com o ar a 45, 55 e 65oC e velocidade de 1,5 m/s. O calor especifico apresentou uma relacao quadratica com o teor de umidade.

PALAVRAS-CHAVE: Curcuma; calor especifico; secagem.
The Role of Polymer Cations in The Polymerization and Electrical Conductivity of Polycarbazole (1985)

Abstract The high electrical conductivities (lohm−1cm−1) in 3,3' polycarbazole charge transfer complexes originate from hopping of radical cations delocalized over only two carbazole units. Although some intramolecular transport must occur a significant intermolecular hopping component must be present. In fact there is significant evidence from model compound studies that distinct bound states exist between radical cations on adjacent chains. The radical cations in the N-methyl substituted polymers are so stable that the conductivity remains unchanged for months in air. These same radical cations can propagate a polymerization reaction through exposed chain ends in molten iodine or bromine solvents. Polymerizations, charge transfer doping, solvent casting thus can be carried out by simply dissolving monomer in the molten halogen. The polymerizing liquid iodine solutions can be reduced by S2O4,= to produce neutral polymer.
Redundant Communication Architectures: How They Benefit the Oil and Gas Industry (2019)

The International Electrotechnical Commission (IEC) Standard 61850 has become firmly established for substation automation. However, it is now also more than just an Ethernet-based protocol. Now in its second edition, the protocol has expanded into additional power supply areas because it defines the engineering process, data and service models, the conformity test, and all of the communication functions for substations. In doing so, the range of applications for protection devices is expanded. Multifunction devices are designed to protect, automate, measure, and monitor high- and medium-voltage networks. The standard enables using data from devices produced by different manufacturers. Additionally, redundant data transmission within the grid is standardized. To implement such solutions, there are two new Ethernet redundancy protocols: the Parallel Redundancy Protocol (PRP) and high-availability seamless redundancy (HSR), and these protocols were designed for mission- and time-critical applications in which communication interruptions or delays must not occur. Both protocols comply with IEC Standard 62439-3 for high-availability industrial Ethernet communication networks. PRP and HSR allow systems to continue operating even in the event of a malfunction because a communication path remains in place between the two protection devices even if a network fault occurs. This is especially important in sectors such as the oil and gas (O&G) industry to help prevent system outages. This article outlines some redundancy architectures and the benefits they offer the O&G industry.
Large Optical Backplane With Embedded Graded-Index Glass Waveguides and Fiber-Flex Termination (2016)

Introduction of electro-optical circuit board (EOCB) technologies based on embedded glass waveguides in the system enclosure of current data storage, compute, or switch platforms will be instrumental in accommodating the prohibitive bandwidth densities projected in exascale data centers, access networks, and high-performance computing environments in future. The main focus of this paper is, therefore, on the realization of large EOCB backplanes (350 × 465) mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> with passive dual-star interconnect topologies. The waveguides are embedded inside glass panels using a two-step thermal ion exchange process. The fabricated embedded waveguides are then characterized for propagation and coupling losses across different wavelength ranges and for different coupling arrangements. The fabrication process for these large panels is briefly explained accompanied by the lamination process of four separate glass panels. The connectivity between backplane and peripheral cards is addressed using fiber flex termination with two possible waveguide interfaces-actively assembled pluggable interface and passively assembled adhesive bonded interface. A demonstration platform is also finally reported and the viability evaluated for optical connectivity and system efficiency is tested for the whole system containing fiber flex termination.
Feasibility of, Adherence to, and Satisfaction With Video Game Versus Traditional Self-Training of the Upper Extremity in People With Chronic Stroke: A Pilot Randomized Controlled Trial (2019)

Participants demonstrated high adherence to and satisfaction with both self-training programs. More participants continued to play video games after the intervention, indicating its potential to maintain ongoing activity.
Robots móviles para tareas de desminado humanitario (2013)

Trabajo presentado en el XII workshop del programa RoboCity2030-II subvencionado por la Comunidad de Madrid para el periodo 2010-2013
In Vitro Cultured Melissa officinalis Cells as Effective Ingredient to Protect Skin against Oxidative Stress, Blue Light, and Infrared Irradiations Damages (2021)

Skin is being increasingly exposed to artificial blue light due to the extensive use of electronic devices, which can induce cell oxidative stress, causing signs of early photo aging. The Melissa officinalis phytocomplex is a new standardized cosmetic ingredient obtained by an in vitro plant cell culture with a high content of rosmarinic acid. In this study, we examine the activity of the Melissa officinalis phytocomplex to protect skin against blue light and infrared damages, evaluating the ROS (Radical Oxygen Species) level in keratinocyte cell line from human skin (HaCaT) and Nrf2 (Nuclear factor erythroid 2-related factor 2), elastin, and MMP1 (Matrix Metalloproteinase 1) immunostaining in living human skin explants ex vivo. This phytocomplex demonstrates antioxidant activity by reducing ROS production and thus the oxidant damage of the skin caused by UV and blue light exposure. In addition, it inhibits blue light-induced Nrf2 transcriptional activity, IR-induced elastin alteration, and IR-induced MMP-1 release. This Melissa officinalis phytocomplex is a new innovative active ingredient for cosmetic products that is able to protect skin against light and screen exposure damages and oxidative stress.
Solubility, Diffusivity, and Permeability of Gases in Phosphonium-Based Room Temperature Ionic Liquids:  Data and Correlations (2007)

Reported are the solubility, diffusivity, and permeability data for various gases in five phosphonium-based ionic liquids at 30 °C, as determined with a lag-time technique. The ionic liquids have a viscosity range of 200−3000 cP. The gas solubilities and diffusivities of the phosphonium-based ionic liquids are of the same magnitude as the gas solubilities for the more familiar imidazolium-based liquids. The gas diffusivity appears to be inversely proportional to the viscosity with an average power of 0.35 for the phosphonium-based ionic liquids. This is in contrast to the power of 0.6 for the imidazolium-based ionic liquids, suggesting that the viscosity−diffusivity relationship varies for different classes of ionic liquids. Despite the generally higher viscosities of the phosphonium-based RTILs compared to the imidazolium-based RTILs, the similarity in thermodynamic and transport properties allows the consideration of the phosphonium-based RTILs as low-cost alternatives for reaction media or separation agents. The gases tested were carbon dioxide, ethylene, propylene, butene, and 1,3-butadiene. Also reported are the permeabilities of methane, nitrogen, and oxygen.
Design of Digital Filters for Frequency Weightings Required for Risk Assessments of Workers Exposed to Vibration (2007)

Many workers are exposed to vibration in their industrial environment. Vibration can be transmitted through a vehicle seat or a hand-held power tool. Excessive vibration exposure may cause health problems and therefore it is important that the worker's vibration exposure is assessed, which may require measurement by the equipment manufacturer or the employer. Human exposure to vibration may be measured using accelerometers; however, weighting filters are required to correlate the physical vibration measurements to the human's response to vibration. ISO 2631, BS 6841 and ISO 5349-1 describe suitable weighting filters, but do not explain how to implement them for digitally recorded acceleration data. ISO 8041 Annex C suggests a method but does not provide a solution. By using the bilinear transform, it is possible to transform the analogue equations given in the standards into digital filters. This paper describes the implementation of the weighting filters as digital IIR (Infinite Impulse Response) filters and provides all the necessary formulae to directly calculate the filter coefficients for any sampling frequency. Thus, the filters in the standards can be implemented in any numerical software.
Molecular dynamics analysis of the effects of GTP, GDP and benzimidazole derivative on structural dynamics of a cell division protein FtsZ fromMycobacterium tuberculosis (2018)

The prevailing multi-drug resistance in <i>Mycobacterium tuberculosis</i> continues to remain one of the main challenges to combat tuberculosis. Hence, it becomes imperative to focus on novel drug targets. Filamenting temperature-sensitive mutant Z (FtsZ) is an essential cell division protein, a eukaryotic tubulin homologue and a promising drug target. During cytokinesis, FtsZ polymerises in the presence of GTP to form Z-ring and recruits other proteins at this site that eventually lead to the formation of daughter cells. Benzimidazoles were experimentally shown to inhibit <i>Mtb</i>-FtsZ, with one of the benzimidazole derivatives, M1, being reported to have the minimum inhibitory concentration (MIC) value of 3.13 µg/mL. In the present study, mechanism of destabilisation of FtsZ in the presence of M1 was computationally investigated in the presence of its substrate GTP/GDP employing molecular dynamics (MD) simulation analysis, principal component analysis (PCA), molecular mechanics combined with the generalised Born and surface area continuum salvation (MM-GBSA) and density functional theory (DFT). From the analyses, it is proposed that binding of M1 in the inter-domain cleft induces structural changes in the GTP-binding region that affect GTP binding, thus switching the preference of this protein towards depolymerised state and eventually inhibiting the cell division. Hence, this study provides mechanistic insights into the design of novel benzimidazole inhibitors against <i>Mtb</i>-FtsZ. Communicated by Ramaswamy H. Sarma.
Performance of thermo-optic components based on dielectric-loaded surface plasmon polariton waveguides (2013)

Theoretical analysis of thermo-optic (TO) modulation with dielectric-loaded surface plasmon polariton waveguide (DLSPPW) components at telecom wavelength of 1.55 μm is presented with simulations performed using the finite-element method (FEM). The investigated DLSPPW configuration consists of a 1 μm-thick and 1 μm-wide polymer ridge placed on a 50 nm-thin gold stripe and supported by a buffer layer material covering a Si wafer. Our analysis covers a broad range of parameters, including the buffer layer thickness, its thermal conductivity and the metal stripe width and takes into account the effect of isolation trenches structured along the heated part of waveguide. The results of our simulations agree well with the reported experimental data and provide valuable information for further development of TO plasmonic components with low switching powers, fast responses and small footprints.
Sex and racial differences in bladder cancer presentation and mortality in the US (2008)

Significant differences in tumor characteristics and age at presentation did not fully account for the excess hazard of death from BC among women and African Americans. Other factors, such as choice and efficacy of therapies, differences within a given tumor characteristic group, and/or host factors also may play important roles.
Accessible Optical Wireless Pedestrian-Support Systems for Individuals with Visual Impairment (2014)

We construct a pedestrian support system using visible-light communication with self-illuminated bollards. The system is designed for the requirements of people with weak eyesight and the elderly to notify them of danger and obstacles such as steps and signals. The luminescent color that the color temperature of 2000 K, that is orange, is suitable for communication. And we demonstrate prototype models of visible-light communication with 4PPM modulation format. Moreover, we carry out evaluation experiments with visually impaired people to determine the best distance for danger notification.
Enzymatic isolation of osteoblasts from fetal rat calvaria (1977)

Abstract A microanatomical study of the immature rat calvarium was performed in order to develop a method for the isolation of osteoblasts by enzymatic means. Although generalized osteogenesis was evident in fetal rats, differential growth patterns were observed beginning at 19 days in utero. Considerable portions of the endocranial periosteal bone surface were lined by flattened, less active cells; discrete areas also contained multinucleated osteoclasts. Cell counts of whole calvaria revealed that one fifth of the total cell population were osteoblasts, most of which were located in the central portions of the frontal and parietal bones. Prior excision of these segments permitted the subsequent removal of virtually all periosteal tissues. Cleaned 19‐day fetal bones, incubated in crude collagenase for two hours, released about 40,000 cells/calvarium, consisting of 85‐90% osteoblasts and lesser amounts of connective tissue and bone marrow elements. Because of the relatively small sizes of most extraneous cells, purity on a cell volume basis was approximately 95%. It is predicted this preparation will be useful in the investigation of certain aspects of osteoblastic function.
Removal kinetics of Bacillus cereus spores from a stainless 2. Removal kinetics modelling: Influence of adhesion conditions (2000)

International audience
Synthesis and evaluation of [123I]‐indomethacin derivatives as COX‐2 targeted imaging agents (2009)

Abstract A novel series of iodinated indomethacin derivatives was synthesized, and evaluated as selective inhibitors of COX‐2. Two candidate compounds N ‐( p ‐iodobenzyl)‐2‐(1‐( p ‐chlorobenzoyl)‐5‐methoxy‐2‐methyl‐1 H ‐indol‐3‐yl)acetamide (3) and 1‐( p ‐iodobenzyl)‐5‐methoxy‐2‐methyl‐3‐indoleacetic acid (9) possessed optimum properties suitable for potential in vivo imaging. Arylstannane precursors for radioiododestannylation were synthesized in 70–85% yield from the iodo compounds by reaction with hexabutylditin and tetrakis (triphenylphosphine)palladium(0) in refluxing dioxane. Radioiododestannylation was conducted by reaction with carrier‐added Na[ 123 I] in the presence of Chloramine‐T in an EtOAc/H 2 O binary system under acidic conditions (pH 3.5), allowing direct isolation of the labeled products by separation of the organic phase. Radioiodinated products [ 123 I]3 and [ 123 I]9 were recovered in a decay‐corrected radiochemical yield of 86–87% and radiochemical purity of 98–99%. Copyright © 2009 John Wiley &amp; Sons, Ltd.
Jitter-constrained camera scheduling in CCTV surveillance networks (2016)

CCTV-based surveillance networks are widely used for security in public places. An important installation problem is to assign a camera schedule with which the system can choose which camera to record its video frames to storage at a certain time. Because of the resource constrained and bandwidth limitation, only a subset of raw video frames can be recorded for a camera. For security concerns, it is expected that the captured frames from the same camera should have equal temporal distance between any two successive ones. If all the distances are not the same, there is jitter. An optimal schedule should minimize the amount of temporal jitter as well as ensure that the jitter between two successive video frames is not greater than a bound. In this paper, the formulation of the scheduling problems is presented. Furthermore, efficient scheduling algorithm is proposed to find feasible schedules given a jitter bound. Experimental results show the efficiency and practicability of the proposed algorithms.
Significant Improvement of Mechanical Properties for Polyvinyl Alcohol Film Prepared from Freeze/Thaw Cycled Gel (2013)

The mechanical properties of polyvinyl alcohol (PVA) films prepared by evaporating water from freeze/thaw cycled gel were investigated as a function of the number of freeze/thaw cycles. The maximum stress of the PVA film prepared by freeze/thaw cycling was larger than that prepared without the freeze/thaw cycle process. The largest maximum stress was 46.2 MPa for a film prepared with 10 freeze/thaw cycles, which was twice as large as that for a cast PVA film without freeze/thaw cycling (22.3 MPa). This is due to the formation of small crystallites during the freeze/thaw cycle process. Furthermore, when the film was annealed at 130°C, the maximum stress was as high as 181 MPa which was comparable to that for PVA films prepared using additives. The crystallinity is not the main factor that determines the maximum stress for either the non-annealed or annealed freeze/thaw cycled films, but the glass transition temperature is well correlated with the maximum stress, irrespective of the annealing process. This is due to the different molecular morphology; the non-annealed freeze/thaw cycled film consists of many small crystallites, but the annealed film consists of larger crystallites formed during the annealing process.
Design, Synthesis and Biological Activity Testing of Library of Sphk1 Inhibitors (2022)

Our team discovered a moderate SphK1 inhibitor, <b>SAMS10</b> (IC<sub>50</sub> = 9.8 μM), which was screened by computer-assisted screening. In this study, we developed a series of novel diaryl derivatives with improved antiproliferative activities by modifying the structure of the lead compound <b>SAMS10</b>. A total of 50 new compounds were synthesized. Among these compounds, the most potent compound, named <b>CHJ04022Rb,</b> has significant anticancer activity in melanoma A375 cell line (IC<sub>50</sub> = 2.95 μM). Further underlying mechanism studies indicated that <b>CHJ04022R</b> exhibited inhibition effect against PI3K/NF-κB signaling pathways, inhibited the migration of A375 cells, promoted apoptosis and exerted antiproliferative effect by inducing G2/M phase arrest in A375 cells. Furthermore, acute toxicity experiment indicated <b>CHJ04022R</b> exhibited good safety in vivo. Additionally, it showed a dose-dependent inhibitory effect on the growth of xenograft tumor in nude mice. Therefore, <b>CHJ04022R</b> may be a potential candidate for the treatment of melanoma.
Productivity, the Workforce, and Technology Education (1991)

Scholarly Communication is a dynamic landscape, and we are continually evolving. Many scholarly communications activities have spun-off into their own departments, such as VT Publishing and Digital Imaging and Preservation Services, and Digital Library Development. Our focus is on supporting the creation and dissemination of scholarship.