gebhart/patrepeval huggingface dataset:
Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a (2010)

One of the major therapeutic strategy in cystic fibrosis aims at developing modulators of cystic fibrosis transmembrane conductance regulator (CFTR) channels. We recently discovered methylglyoxal alpha-aminoazaheterocycle adducts, as a new family of CFTR inhibitors. In a structure-activity relationship study, we have now identified GPact-11a, a compound able not to inhibit but to activate CFTR. Here, we present the effect of GPact-11a on CFTR activity using in vitro (iodide efflux, fluorescence imaging and patch-clamp recordings), ex vivo (short-circuit current measurements) and in vivo (salivary secretion) experiments. We report that GPact-11a: 1) is an activator of CFTR in several airway epithelial cell lines; 2) activates rescued F508del-CFTR in nasal, tracheal, bronchial, pancreatic cell lines and in human CF ciliated epithelial cells, freshly dissociated from lung samples; 3) stimulates ex vivo the colonic chloride secretion and increases in vivo the salivary secretion in cftr(+/+) but not cftr(-/-) mice; and 4) is selective for CFTR because its effect is inhibited by CFTR(inh)-172, GlyH-101, glibenclamide and GPinh-5a. To conclude, this work identifies a selective activator of wild-type and rescued F508del-CFTR. This nontoxic and water-soluble agent represents a good candidate, alone or in combination with a F508del-CFTR corrector, for the development of a CFTR modulator in cystic fibrosis.
Dysfonctionnement myocardique et choc septique (2004)

Myocardial dysfunction frequently accompanies severe sepsis and septic shock. It is now clear that such a myocardial depression, as evidenced by biventricular alteration, is present during the early phase of sepsis in most patients. Myocardial depression exists despite a fluid loading-dependent hyperdynamic state and usually recovers within 7 to 10 days in survivors. Myocardial dysfunction does not appear to be due to irreversible structural abnormalities nor to myocardial hypoperfusion, but rather linked to many circulating mediators including cytokines. At a cellular level, reduced myocardial contractility could be related in part to apoptosis and induced by both nitric oxide-dependent and nitric oxide-independent mechanisms. However, whatever the mechanism involved, it leads to calcium homeostasis abnormality. The present review describes both the diagnosis procedure and the molecular and cellular pathways of sepsis-induced myocardial depression.
Single-Pass Corn and Stover Harvesters: Development and Performance (2013)

A major constraint on the wider commercial utilization of biomass feedstocks is the dispersed, diverse and low densitynature of crop biomass. For low specific costs, improved or alternative methods are needed to collect, handle, andstore biomass such as corn stover. So far, corn stover collection has depended on baling, initially with smallrectangular balers, then with large round balers. But round-baling of corn stover can be a two- or three-passoperation. Another approach is to hitch a baler directly onto a combine, capture the crop effluent and square-bale it.The problem is that there is a strict limit in stover moisture if bales are to be stored. Balers that are not hitched to thecombine pick up dirt and most of the cobs are left in the field. Several alternative technologies were proposed,developed and successfully demonstrated for a lower cost single-pass system capable of suitable densification foreconomical transport.<br><br>The initial work was supported largely by a DOE grant, DE-FC36-OOGO10695, Handling and Densification forCommercial Processing of Biomass Feedstock.<br><br>The new corn stover harvest systems should be capable of harvesting stover at any level of moisture even while thegrain is being harvested. All the cobs are collected, the stover does not touch the ground and a controlled amount ofresidue can be left to meet any conservation requirements. Several approaches were addressed and the equipmentdescribed here was (a) and (b) Two-tier Heads; (c) a Stover Caddy, that can be used in conjunction with either anunmodified corn head to collect the combine effluent or with (d) a modified Whole Plant Harvesting Head.Collection was facilitated with a modified Stakhand Stover Wagon, (e) a purpose-built Stover wagon with somehydraulic compaction capability and moving floor was fabricated and matched to a Fastrac Tractor.Costs of an On-time harvest were estimated to be as low as $3.76 per ton of stover. Or if the harvest is slowed by thestover collection, the costs per ton was estimated to be $4.36 for the delayed harvest. These figures compare mostfavorably with baling after the grain harvest.
Flow Cytometry and Cell Sorting: Pushing the Technology to the Limit (2005)

Journal Article Flow Cytometry and Cell Sorting: Pushing the Technology to the Limit Get access G van den Engh G van den Engh Institute for Systems Biology, Seattle, Washington Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 11, Issue S02, 1 August 2005, Pages 242–243, https://doi.org/10.1017/S1431927605510274 Published: 01 August 2005
Long-term results of imatinib mesylate therapy in philadelphia chromosome (Ph) positive chronic phase chronic myelogenous leukemia (CML) post interferon-a (IFN) failure M.D. Anderson experience in 261 patients (2004)

6622 Background: The initial results of imatinib in Ph-positive CML in chronic phase post IFN failure were positive with a median follow up times of 17 months. The major cytogenetic (CG) response rate (Ph 5% (p<0.05) or prior hematologic resistance to IFN (p=0.01). Achieving any CG response at 3 months was associated with a 4-year survival rate of 95% (versus 78% for others; p=0.0001); the 4-year FFP rates were 94% versus 64%, respectively (p<0.0001). Achieving a major CG response at 6 months was associated with a 4-year survival rate of 95% (versus 81% for others; p=0.001); the 4-yr FFP rates were 94% versus 68% (p<0.0001). Among 167 patients achieving CG CR, 152 pts had quantitative PCR (QPCR) studies: 82 pts (49%; 31% total) had a major molecular response (QPCR= BCR-ABL/ABL <0.05%) and 38 pts (15%) had a complete molecular response (BCR-ABL undetectable). The 3-yr cumulative major molecular response rate was 55%, and complete molecular response rate 22%. Compared with a historical group of 131 similar patients in CML chronic phase post IFN failure treated with non-imatinib therapies, imatinib was associated with better 4-year survival rates (88%, versus 35% p<0.0001); this survival advantage for imatinib was confirmed by multivariate analysis (p<0.0001). Conclusions: The results with imatinib in CML chronic phase post IFN failure are improving and durable. Major and complete responses are now noted in a substantial proportion of patients with longer follow-up time. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Novartis; Supergen
Objective Assessment of the Utility of Chromoendoscopy with a Support Vector Machine (2018)

Objective assessment by SVM found AIM to be suitable for diagnosis of early GC based on color differences.
Sound absorption in metallic foams (1999)

The sound absorption capacity of one type of aluminum alloy foams—trade name Alporas—is studied experimentally. The foam in its as-received cast form contains closed porosities, and hence does not absorb sound well. To make the foam more transparent to air motion, techniques based on either rolling or hole drilling are used. Under rolling, the faces of some of the cells break to form small sharp-edged cracks as observed from a scanning electronic microscope. These cracks become passage ways for the in-and-out movement of air particles, resulting in sound absorption improvement. The best performance is nevertheless achieved via hole drilling where nearly all of the sound can be absorbed at selected frequencies. Combining rolling with hole drilling does not appear to lend additional benefits for sound absorption. Image analysis is carried out to characterize the changes in cell morphologies due to rolling/compression, and the drop in elastic modulus due to the formation of cracks is recorded. The effects of varying the relative foam density and panel thickness on sound absorption are measured, and optimal relative density and thickness of the panel are identified. Analytical models are used to explain the measured increase in sound absorption due to rolling and/or drilling. Sound absorbed by viscous flow across small cracks appears to dominate over that dissipated via other mechanisms.
Evaluation Of Waste Concrete Road Materials For Use In Oyster Aquaculture – Field Test (2015)

The overall objective of this study was to determine the suitability of recycled concrete aggregate (RCA) from road projects as bottom conditioning material for on-bottom oyster aquaculture in the Chesapeake Bay. During this Phase of the study, the research team placed RCA on test plots in the Chesapeake Bay to evaluate the impact on the benthic community. Miniature oyster reefs were also built to determine potential impacts or disruptions of RCA on the use of traditional harvesting gear. The results of this project showed that (1) There was no significant difference between substrate type (RCA, oyster shell) on benthic community structure, oyster recruitment, and the abundance and size distribution of key faunal species, demonstrating that RCA, as an alternative material, was generally similar to natural oyster shell with regard to ecosystem services provided, and (2) RCA makes a suitable substrate for supporting oysters for aquaculture operations but would require a veneer of old shell to be placed on top so as not to introduce additional weight to the catch when using shaft tongs.
The hypocholesterolemic activity of orally administered polyene macrolides. (1968)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Regioselectivity and diastereoselectivity in free-radical macrocyclization (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegioselectivity and diastereoselectivity in free-radical macrocyclizationNed A. Porter, Brigitte Lacher, Vincent H. T. Chang, and David R. MagninCite this: J. Am. Chem. Soc. 1989, 111, 21, 8309–8310Publication Date (Print):October 1, 1989Publication History Published online1 May 2002Published inissue 1 October 1989https://pubs.acs.org/doi/10.1021/ja00203a059https://doi.org/10.1021/ja00203a059research-articleACS PublicationsRequest reuse permissionsArticle Views612Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Layer Optimization for Power Reduction in Integrated Circuits (2018)

Layer promotion is a new technique introduced recently for timing optimization at physical implementation stage of an Integrated Circuit (IC). In this paper, we will use the same idea to reduce the power consumption on the interconnection. We implemented the technique and obtained experimental results on a high-speed design made with 7nm technology node. The success criteria are to achieve the highest power reduction without degrading the circuit performance and keep having a good routing of the interconnection. The new nets re-routing power-aware performs an improvement of 20% of total data nets power and a 6% of the entire design total power. This reduction is achieved by optimizing the routing by 40% of data nets that consume more than 92% of the total power in the interconnection.
Care of the Injured Soldier: A Medical Readiness Role for Clinical Hyperbaric Oxygen Therapy (1985)

A brief review of hyperbaric oxygen treatment and its potential application to the care of the injured soldier has been carried out. At the present time, a modern state-of-the-art clinical hyperbaric facility is under construction at Wright-Patterson Air Force Base in Dayton, Ohio. This facility will have three chambers with the capability for routine treatment of 36 patients each day. Plans are underway for a similar facility at Travis Air Force Base in California. The USAF School of Aerospace Medicine has an active fellowship training program for physicians, physiologists and nurses.
On a feasibility of a resonant stimulated Raman scattering gyroscope (2017)

We report on the detailed feasibility study of a gyroscope based on stimulated Raman scattering (SRS). We present data of the proof of principle experiments involving single mode resonant SRS observed in packaged single mode WGM resonator characterized with extremely low Rayleigh scattering and corresponding small self-locking range. We discuss reciprocity as well as coherence properties of the Raman emission and present data validating the technique.
Hantavirus Pulmonary Syndrome, French Guiana (2010)

gust 2003 that compared HIV prevalence in 426 patients with Buruli ulcer and 613 controls in southern Benin, HIV prevalence among patients with Buruli ulcer was higher (2.6%, 11/426) than among controls (0.3%, 2/613) (odds ratio 8.1) (8). However, none of these reported HIV-positive patients with Buruli ulcer were treated with rifampin/streptomycin and antiretroviral therapy (8).
RifamycinMode of Action, Resistance, and Biosynthesis (2005)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRifamycinMode of Action, Resistance, and BiosynthesisHeinz G. Floss and Tin-Wein YuView Author Information Department of Chemistry, Box 351700, University of Washington, Seattle, Washington 98195-1700 Cite this: Chem. Rev. 2005, 105, 2, 621–632Publication Date (Web):January 12, 2005Publication History Received10 May 2004Published online12 January 2005Published inissue 1 February 2005https://doi.org/10.1021/cr030112jCopyright © 2005 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views7390Altmetric-Citations381LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (445 KB) Get e-AlertsSUBJECTS:Antimicrobial agents,Bacteria,Genetics,Monomers,Peptides and proteins Get e-Alerts
Cyclotides from Pombalia, Noisettia and Viola Genus: Discovery and Inhibitors of Cellular Migration (2015)

Meri Emili F. Pinto, Jenny Najas Z. Garavito, Luma G. Magalhaes, Adriano D. Andricopulo, Christian W. Gruber, Eduardo M. Cilli, Angelo C. Pinto, and Vanderlan S. Bolzani Institute of Chemistry, Sao Paulo State University UNESP, Araraquara, 14800-060, Brazil; Institute of Chemistry, Federal University of Rio de Janeiro UFRJ, Rio de Janeiro, 21941-909, Brazil; Institute of Physics of Sao Carlos, The University of Sao Paulo -USP, Sao Carlos, 13563-120, Brazil; Center for
Murine echocardiography and ultrasound imaging (2010)

Rodent models of cardiac pathophysiology represent a valuable research tool to investigate mechanism of disease as well as test new therapeutics. Echocardiography provides a powerful, non-invasive tool to serially assess cardiac morphometry and function in a living animal. However, using this technique on mice poses unique challenges owing to the small size and rapid heart rate of these animals. Until recently, few ultrasound systems were capable of performing quality echocardiography on mice, and those generally lacked the image resolution and frame rate necessary to obtain truly quantitative measurements. Newly released systems such as the VisualSonics Vevo2100 provide new tools for researchers to carefully and non-invasively investigate cardiac function in mice. This system generates high resolution images and provides analysis capabilities similar to those used with human patients. Although color Doppler has been available for over 30 years in humans, this valuable technology has only recently been possible in rodent ultrasound. Color Doppler has broad applications for echocardiography, including the ability to quickly assess flow directionality in vessels and through valves, and to rapidly identify valve regurgitation. Strain analysis is a critical advance that is utilized to quantitatively measure regional myocardial function. This technique has the potential to detect changes in pathology, or resolution of pathology, earlier than conventional techniques. Coupled with the addition of three-dimensional image reconstruction, volumetric assessment of whole-organs is possible, including visualization and assessment of cardiac and vascular structures. Murine-compatible contrast imaging can also allow for volumetric measurements and tissue perfusion assessment.
Near-Infrared Fluorescence Imaging and Photodynamic Therapy for Liver Tumors (2021)

Surgery with fluorescence equipment has improved to treat the malignant viscera, including hepatobiliary and pancreatic neoplasms. In both open and minimally invasive surgeries, optical imaging using near-infrared (NIR) fluorescence is used to assess anatomy and function in real time. Here, we review a variety of publications related to clinical applications of NIR fluorescence imaging in liver surgery. We have developed a novel nanoparticle (indocyanine green lactosome) that is biocompatible and can be used for imaging cancer tissues and also as a drug delivery system. To date, stable particles are formed in blood and have an ~10-20 h half-life. Particles labeled with a NIR fluorescent agent have been applied to cancer tissues by the enhanced permeability and retention effect in animals. Furthermore, this article reviews recent developments in photodynamic therapy with NIR fluorescence imaging, which may contribute and accelerate the innovative treatments for liver tumors.
C-51 * Differences in Neuropsychological Test Performance at 3 Months Post-Injury among CT Positive and CT Negative Mild TBI Patients (2014)

Objective: The purpose of this study was to examine 3-month neuropsychological outcomes following mTBI (GCS 13–15) in participants with and without positive CT scans. Method: 321 participants with mTBI (GCS score >12) from the prospective multicenter Transforming Research and Clinical Knowledge (TRACK-TBI) study were included in the current analyses, 44% of whom had positive CT scans acquired at the Emergency Department. Participants received a 3-month follow up assessment on neuropsychological measures including Trail Making Test (TMT), WAIS-IV Processing Speed (PSI) Index, and California Verbal Learning Test (CVLT). Psychiatric and TBI history, and post-concussion symptoms (Rivermead Post-Concussion Symptoms Questionnaire–RPQ) were also obtained. Results: Using ANOVA, the CT+ group demonstrated significantly lower PSI scores (F = 4.46, p < .01), CVLT Total Learning Trials 1–5 (F = 28.04, p < .001), CVLT Short Delay Free Recall (F = 21.26, p < .01), and CVLT Long Delay Free Recall (F = 26.62, p < .01) scores compared to the CT- group. Differences remained after controlling for age, psychiatric history and prior TBI. Conclusion(s): Individuals with mTBI are often conceptualized homogeneously with respect to severity and recovery. However, results demonstrate variability within this group at 3-months post-injury. Those who were CT+ had poorer neurocognitive performance relative to those who were CT-, even after accounting for demographic and pre-injury factors. This underscores the heterogeneity within individuals with mTBI and highlights the importance of serial follow-up including neurocognitive measures.
Intracochlear force measurements during electrode insertion: Recommendation for evaluation, comparability and presentation (2023)

Objective Intracochlear pressure and force are assumed to be important factors during cochlea implant electrode insertion. Residual hearing preservation surgery is aiming to minimize the occurrence of both factors. While for the occurrence of intracochlear pressure max. value and the peak frequency are important parameter, intracochlear force is commonly less detailed described. Partial insertional estimation of force can make the impression of a low force value although the insertion is not completed and the max. force described. The aim of this study was to compare force measurement parameter e.g. speed and insertion depth in terms of relevance for hearing preservation.
Attempted definition by immunoblotting of the causes of reactivity in suspected false-positive sera in theBrucella oviscomplement fixation test (1996)

Seventy-nine suspected false-positive sera, obtained over 1 year from routine submissions for Brucella ovis serological testing, were used in this study. These sera, which exhibited titres in the complement fixation test, but which because of their epidemiological history and their reactions in the enzyme-linked immunosorbent assay and gel diffusion test were suspected to be false positives, were further analysed by immunoblotting. In blots, using B. ovis antigens, rough lipopolysaccharide was identified as the major, immuno-reactive bacterial component. Antibodies against this macromolecule were present in 46.8% of the suspected false-positive sera. In order to find out if rough lipopolysaccharides from other bacterial species could be the possible cause for the suspected false positivity, 23 sera with highest complement fixation titres were reacted in blots with cell extracts from Escherichia coli, Yersinia enterocolitica, Yersinia pseudotuberculosis, Bortedella bronchiseptica, Actinobacillus seminis, Campylobacter fetus fetus, Campylobacter jejuni, Mycobacterium paratuberculosis, Mycobacterium phlei, Corynebacterium pseudotuberculosis and pure lipopolysaccharides from Escherichia coli and Salmonella typhimurium. Despite high frequencies of antibody reaction with proteins in most of these bacterial cell extracts, which reflect the presence of infections with these bacteria, immuno-staining in the rough lipopolysaccharide region was not observed.
Time-Dependent Model of an Acousto-Optic Tunable Filter for Multiple-Channel Operations (1995)

With its wide tunability and multiple-channel switching capability, the integrated version of acousto-optic tunable filters (AOTF’s) has shown healthy development in recent years for wavelength-division-multiplexing (WDM) optical-communication network applications as 2 × 2 and 4×4 frequency-selective optical switches.