gebhart/patrepeval huggingface dataset:
Reaction-torque-based reflected wave rejection for vibration suppression of integrated resonant and time-delay system (2015)

The vibration suppression on a resonant system, based on the reflected wave rejection, has been recently proposed. In the method, the resonant system is modeled through a wave equation, in order to consider high order vibrations and vibration suppression is achieved by eliminating a reflected wave. However, it is difficult to implement such method when there are input and output time-delays, because it requires the implementation of the inverse of a time delay. Under such background, vibration suppression on the integrated resonant and time-delay system by using a modified reflected wave rejection has been proposed. However, a problem still remains, which is to need to use load-position information. Therefore, this paper proposes a novel vibration suppression method for systems including time delays by using a reaction-torque-based reflected wave rejection, which does not use the load position information. The novel reflected wave rejection can estimate and compensate the reflected wave by using motor position and reaction-torque information which is estimated by a reaction-torque observer. The validity of the proposed method is confirmed by experimental results.
A general route to optically pure prostaglandins from a D-glucose derivative (1981)

R. J. Ferrier and P. Prasit, J. Chem. Soc., Chem. Commun., 1981, 983 DOI: 10.1039/C39810000983
Tet2 Controls β cells Responses to Inflammation in Type 1 Diabetes (2020)

Abstract β cells may participate and contribute to their own demise during Type 1 diabetes (T1D). We identified a novel role of Tet2 in regulating immune killing of β cells. Tet2 is induced in murine and human β cells with inflammation but its expression is reduced in surviving β cells. Tet2-KO mice that receive WT bone marrow transplants develop insulitis but not diabetes and islet infiltrates do not eliminate β cells even though immune cells from the mice can transfer diabetes to NOD/ scid recipients. Tet2-KO β cells show reduced expression of inflammatory genes, associated with closed transcription factor binding sites. Tet2-KO recipients are protected from transfer of disease by diabetogenic immune cells. We conclude that Tet2 regulates pathologic interactions between β cells and immune cells and controls intrinsic protective pathways. Modulating TET2 may enable survival of β cells or their replacements in the setting of pathologic immune cells.
The ESO Program and Activities on Laser Guide Stars for Adaptive Optics (2006)

ESO has installed several adaptive optics systems on the VLT telescopes in Chile, and has a robust program to implement Laser Guide Stars. In this article it will be reviewed the status of the LGS Facility, a collaborative project together with Max Planck Institutes in Garching and in Heidelberg, recently installed on Paranal, and its first results. The activities toward multiconjugate LGS-AO, LGS-AO for the European ELT project and the development progress in fiber lasers will also be reviewed.
Fundamentals of cavity-enhanced polarimetry for parity-nonconserving optical rotation measurements: Application to Xe, Hg, and I (2014)

We present the theoretical basis of a cavity-enhanced polarimetric scheme for the measurement of parity-nonconserving (PNC) optical rotation. We discuss the possibility of detecting PNC optical rotation in accessible transitions in metastable Xe and Hg and ground-state I. In particular, the physics of the PNC optical rotation is presented and we explore the line-shape effects on the expected PNC optical rotation signals. Furthermore, we present an analysis of the eigenpolarizations of the cavity-enhanced polarimeter, which is necessary for understanding the measurement procedure and the ability of employing robust background subtraction procedures using two signal reversals. Using recent atomic structure theoretical calculations, we present simulations of the PNC optical rotation signals for all proposed transitions, assuming a range of experimentally feasible parameters. Finally, the possibility of performing sensitive measurements of the nuclear-spin-dependent PNC effects is investigated for the odd-neutron nuclei $^{129}\mathrm{Xe}$ and $^{199}\mathrm{Hg}$ and the odd-proton nucleus $^{127}\mathrm{I}$.
Radio propagation effects of rocket exhaust plasmas. (1965)

Rocket exhaust plasma disturbance on radio transmission between vehicle and ground station noting multipath, forward and backscatter
Cellular epigenetics: control of the size, shape, and spatial distribution of transformed foci by interactions between the transformed and nontransformed cells. (1994)

NIH 3T3 cells that are passaged frequently at low density in high (10%) calf serum lose their original capacity to produce transformed foci on a monolayer of nontransformed cells. They can then be used to form a monolayered background for the assay of the number of focus-forming cells from a transformed population. Continuation of the low-density passages for many weeks gives rise to a population that can suppress the full development of foci by a transformed line. The suppression appears to occur only after the background cells have become confluent and contact inhibited. It can also cause the disappearance of light foci that had developed before suppression began. Another subline of cells that were passaged at cloning density only once a week lose their focus-forming capacity more slowly than those passaged thrice weekly. When used as a background for the assay of a transformed line, they permit continuous expansion of the foci, with no sign of suppression. Not only the number and size of foci but also their detailed morphology is influenced by the background on which they are formed. A suppressive background can also determine the spatial distribution of foci, presumably as a result of gradients in local cell density of the background. The permissiveness of a nontransformed cell population for focus formation by transformed cells appears to be related to the capacity of the nontransformed population itself to undergo transformation when exposed to the constraints used to induce transformation. These findings indicate there are many degrees of capacity to suppress focus formation and to overcome suppression. They have significance for tumor development and for the epigenetic interactions of normal development.
Activation of 2-propyn-1-ol derivatives by (arene)ruthenium(II) complexes: new route to (alkenylcarbene)- and (polyenylcarbene)-metal complexes (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTActivation of 2-propyn-1-ol derivatives by (arene)ruthenium(II) complexes: new route to (alkenylcarbene)- and (polyenylcarbene)-metal complexesDidier Pilette, Khalid Ouzzine, Hubert Le Bozec, Pierre H. Dixneuf, Clifton E. F. Rickard, and Warren R. RoperCite this: Organometallics 1992, 11, 2, 809–817Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/om00038a046https://doi.org/10.1021/om00038a046research-articleACS PublicationsRequest reuse permissionsArticle Views282Altmetric-Citations130LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A user-friendly method to analyze cost effectiveness of different electric bus systems (2017)

This paper is an update on a method to analyze and compare electric bus and charging systems from a total\ncost perspective. The method is useful for proposing a suitable combination of bus and charger systems\ndepending on the route specifications, timetables and other local conditions. In this update, a user-friendly\ntool which simplifies the analysis process is presented. The analysis tool enables the user to experimentally\ninvestigate and quantify the trade-offs between parameters such as battery size, charging strategies and\ncharging infrastructure, vehicle fleet and operational costs from a total cost perspective
Randomized study of two "rescue" therapies for helicobacter pylori-infected patients after failure of standard triple therapies (2001)

In patients who failed standard eradicating treatments, a 10-day course of rifabutin with pantoprazole and amoxycillin is more effective and well tolerated than the quadruple therapy.
The global fight to develop antipoverty vaccines in the anti-vaccine era (2018)

Antipoverty vaccines are the vaccines targeting a group of approximately 20 neglected tropical diseases (NTDs), as currently defined by the World Health Organization (WHO). The "antipoverty" moniker refers to the fact that NTDs trap populations in poverty due to their chronic and deleterious effects on child intellect and worker productivity. Therefore, NTD vaccines can be expected to promote both global health and economic advancement. Unfortunately, antipoverty vaccine development has lagged behind vaccines for major childhood infections and pandemic threats, despite evidence for their cost-effectiveness and cost-savings. Currently, the only licensed vaccines for NTDs include those for yellow fever, dengue, and rabies, although several other NTD vaccines for hookworm disease, schistosomiasis, leishmaniasis, and Zika and Ebola virus infections are in different stages of clinical development, while others are at the preclinical development stage. With the exception of the viral NTD vaccines there so far has been minimal industry interest in the antipoverty vaccines, leaving their development to a handful of non-profit product development partnerships. The major scientific and geopolitical hurdles to antipoverty vaccine development are discussed, including a rising antivaccine ("antivax") movement now entering highly populated low- and middle-income countries.
Cytochrome c oxidase dysfunction in sepsis (2007)

Sepsis, the principal cause of death in critically ill patients, is associated with impaired oxygen extraction by tissues. One possible explanation is the development of mitochondrial dysfunction and ineffective oxygen utilization. This abnormality has been termed cytopathic hypoxia. This may be caused by an abnormality in the transport of electrons down the cytochrome chain on the mitochondrial inner membrane. In this article we review our studies on abnormalities in the function of complex IV (cytochrome oxidase), the final electron acceptor in this chain. In addition, we provide evidence that administration of cytochrome c may overcome these abnormalities and provide a novel therapeutic alternative.
An Instance of the Fruiting-Body Formation of Tricholoma matsutake. (1995)

In 1985-1987, the ecology of Shiro which had produced fruiting-body of Tricholoma matsutake was studied in the forest of Pinus densiflora, Sadogashima, Niigata Prefecture. There are three types of Shiro showing circular and crescent with pine root and independent circular with pine root. The latter one developed in the soil which the root of pine tree did not grow well. When the mycelia from the latter Shiro are mixed with the sawdust medium containing several nutrients and LVD (separated sulphite pulp waste from softwood) and incubated in the plastic case at 24°C, the fruiting-body of T. matsutake was formed 90 days after the mixing. The growth of mycelia (Z-1 strain) isolated from the fruiting-body formed in the plastic case was better than those produced in nature. Moreover, Z-1 strain formed some small fruiting-bodies in the sawdust nutrient medium containing LVD and Sphagnum sp. (commercial plant) . Other strains, however, did not form any fruiting-body in the same culture conditions. Therefore, the mycological and physiological characters of Z-1 strain isolated will be examined in further investigation.
Tool Support for Managing Clone Refactorings to Facilitate Code Review in Evolving Software (2017)

Developers often perform copy-and-paste activities. This practice causes the similar code fragment (aka code clones) to be scattered throughout a code base. Refactoring for clone removal is beneficial, preventing clones from having negative effects on software quality, such as hidden bug propagation and unintentional inconsistent changes. However, recent research has provided evidence that factoring out clones is not always to reduce the risk of introducing defects, and it is often difficult or impossible to remove clones using standard refactoring techniques. To investigate which or how clones can be refactored, developers typically spend a significant amount of their time managing individual clone instances or clone groups scattered across a large code base. To address the problem, this paper presents a technique for managing clone refactorings, Pattern-based clone Refactoring Inspection (PRI), using refactoring pattern templates. By matching the refactoring pattern templates against a code base, it summarizes refactoring changes of clones, and detects the clone instances not consistently factored out as potential anomalies. PRI also provides novel visualization user interfaces specifically designed for inspecting clone refactorings. In the evaluation, PRI analyzes clone instances in six open source projects. It identifies clone refactorings with 94.1% accuracy and detects inconsistent refactorings with 98.4% accuracy. Our results show that PRI should help developers effectively inspect evolving clones and correctly apply refactorings to clone groups.
Examining the Definition of Ventilator-Associated Pneumonia in the Trauma Setting: A Single-Center Analysis (2023)

<b><i>Background:</i></b> Ventilator associated pneumonia (VAP) is defined by the American College of Surgeons Trauma Quality Improvement Program (ACS TQIP) using laboratory findings, pathophysiologic signs/symptoms, and imaging criteria. However, many critically ill trauma patients meet the non-specific laboratory and sign/symptom thresholds for VAP, so the TQIP designation of VAP depends heavily upon imaging evidence. We hypothesized that physician opinions widely vary regarding chest radiograph findings significant for VAP. <b><i>Patients and Methods:</i></b> The TQIP Spring 2021 Benchmark Report (BR) was used to identify 14 patients with VAP at an academic Level 1 Trauma Center. Critically ill trauma patients (n = 7) who spent at least four days intubated and met TQIP's laboratory and sign/symptom thresholds for VAP but did not appear as VAPs on the BR comprised the control group. For each deidentified patient, four successive chest radiographic images were compiled and arranged chronologically. Cases and controls were randomly arranged in digital format. Blinded physicians (n = 27) were asked to identify patients with VAP based solely on imaging evidence. <b><i>Results:</i></b> Radiographic evidence of VAP was highly subjective (Krippendorff α = 0.134). Among physicians of the same job description, inter-rater reliability remained low (α = 0.137 for trauma attending physicians; α = 0.141 for trauma fellows; α = 0.271 for radiologists). When majority judgment was compared to the TQIP BR, there was disagreement between the two tests (Cohen κ = <sup>-</sup>0.071; sensitivity, 64.3%; specificity, 28.6%). <b><i>Conclusions:</i></b> Current definitions of VAP rely on subjective imaging interpretation and ignore the reality that there are numerous explanations for opacities on CXR. The inconsistency of physicians' imaging interpretation and protean physiologic findings for VAP in trauma patients should preclude the current definition of VAP from being used as a quality improvement metric in TQIP.
Synthesis and luminescence characteristics of conjugated dendrimers with 2,4,6‐triaryl‐1,3,5‐triazine periphery (2005)

Abstract We have synthesized conjugated dendrimer with triazine peripheries, and their luminescence properties were investigated. The dendrimers consist of dendritic triazine wedges for electron transport, distyrylbenzene core as an emitting moiety, and t ‐butyl peripheral groups for good processing properties. The dendrimers have LUMO values of about −2.7 eV possibly because of the triazine moiety with high electron affinity. Photoluminescence study indicates that energy transfer occurs from the triazine wedges to the stilbene bridge, and finally to the core chromophore units due to a cascade decrease of bandgap from the peripheral wedge to core moiety. Therefore, the emission wavelength was determined by the structure of the core unit. The energy transfer efficiency of distyrylbenzene‐cored dendrimers was about 75 and 55% for Trz‐1GD‐DSB and Trz‐2GD‐DSB, respectively. A preliminary electroluminescence property also was investigated. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 254–263, 2006
Revisiting the Site-Competition Doping of 4H-SiC: Cases of N and Al (2020)

Because the well-known site-competition and step-controlled epitaxy rules cannot reasonably describe all the incorporation processes of the main impurities (Al and N) into 4H-SiC during epitaxy, the concept of replacement incorporation was proposed and applied to explain the experimental results published so far. In this model, the transient formation of C or Si vacancies at the surface or sub-surface of terraces is proposed to play a key role by destabilizing the impurities sitting on them. In addition to the availability of these vacancies at the surface, desorption was proposed to be a very important limiting process for Al incorporation while only occasionally relevant for N incorporation. The main 4H-SiC epitaxial growth parameters are reviewed and discussed according to the proposed replacement model.
Optimizing Particle-Mediated Epidermal Delivery of an Influenza DNA Vaccine in Ferrets (2012)

Particle-mediated DNA delivery technologies ("gene guns") have been shown in both animal and clinical studies to be an effective means of increasing the immunogenicity and protective efficacy of DNA vaccines. The primary goal in optimizing particle-mediated epidermal delivery (PMED) vaccination in different animal models is to achieve delivery of DNA-coated gold beads into the viable epidermis. Two key para-meters that influence this outcome include the delivery pressure, which controls the penetrative force of the beads into the skin, and the anatomical site of DNA delivery. Although the ferret has been extensively used as an experimental model for influenza infection in humans, very few studies have investigated the capacity for PMED DNA vaccination to induce protective immune responses in ferrets. Here we describe methods to optimize DNA vaccine delivery using the PowderJect XR1 gene delivery in ferrets. We first assess the effects of firing pressure on both the delivery of DNA-coated gold beads into the desired epidermal layer and the degree of DNA vaccine reporter gene expression at the target site. Second, we evaluate the impact of vaccination site (skin or tongue) on DNA vaccine immunogenicity by measuring serum antibody responses to the model antigens influenza virus hemagglutinin and hepatitis B core antigen. Results from these studies support the use of the PowderJect XR1 device in ferrets for the study of prophylactic and therapeutic DNA vaccines against clinically important diseases such as influenza virus infection.
Monotone decomposition of 2-additive Generalized Additive Independence models (2018)

The GAI (Generalized Additive Independence) model proposed by Fishburn is a generalization of the additive value function model, which need not satisfy preferential independence. Its great generality makes however its application and study difficult. We consider a significant subclass of GAI models, namely the discrete 2-additive GAI models, and provide for this class a decomposition into nonneg-ative monotone terms. This decomposition allows a reduction from exponential to quadratic complexity in any optimization problem involving discrete 2-additive models, making them usable in practice.
Polyplex Based On Polycarbonate Polymers For An Efficient Delivery Of An Anti-Angiogenic siRNA (2014)

To meet the challenge of gene therapy and deliver small-interfering RNA (siRNA) into the cytoplasm of target cells, several barriers must be overcome. The most widely used polymeric vector is polyethylenimine (PEI) but its cytotoxicity limits its use in vivo. As a safe alternative, we designed and synthesized guanidium and morpholino functionalized biocompatible polycarbonate polymer that are able to complex the siRNA with a significantly lower cytotoxicity than PEI [1]. The siRNA used in the study is specifically targeted against histone deacetylase 7 (HDAC7) mRNA. The specific shutdown of HDAC7 protein disturbs the angiogenic process of endothelial cells, making it an attractive target for an anti-angiogenic therapy, interfering with the cancerous tumor growth and metastasis development [2].
TAVR Risk Scoring Using Established versus New Scoring Systems: Role of the New STS/ACC Model (2017)

Objectives: Despite more than ten years of clinical experience with transcatheter aortic valve replacement (TAVR) a reliable risk score model is not yet available. Only recently a TAVR-specific risk score model has been developed: the STS/ACC TAVR in-hospital mortality risk score. This study validates the STS/ACC TAVR score for predicting in-hospital mortality and compares its ability to predict 30-day mortality with that of four other established risk models (EuroScore I, EuroScore II, STS-PROM, and German AKL) at a tertiary care center in Germany.
Comparison of laboratory threshold criteria in drug‐induced liver injury detection algorithms for use in pharmacovigilance (2020)

More stringent criteria (DEWG and DILIN) performed better in terms of PPV, specificity, accuracy and F-measure. CIOMS performed better in terms of sensitivity. An algorithm with high sensitivity is useful in pharmacovigilance for detecting rare events and to avoid missing cases. Requiring at least two abnormal liver chemistries during hospitalization and text-word searching in the discharge summaries decreased false positives without loss in sensitivity.