gebhart/patrepeval huggingface dataset:
A Page-Hinkley Based Method For Hfos Detection In Epileptic Depth-Eeg (2018)

Publication in the conference proceedings of EUSIPCO, Kos island, Greece, 2017
Scheduling algorithm with priority of active buffer for variable-length IP packet over input-buffered ATM switch (2002)

In the input buffered ATM (asynchronous transfer mode) switches, HoL (head of line) blocking can be eliminated entirely by VOQ (virtual output queuing), in which each input port maintains a separate buffer for each output port. On the other hand, the IP (Internet protocol) traffic has increased explosively, therefore to manage IP packets over ATM, IP-PIM (IP-parallel iterative matching) has been proposed. However, the queue length of other buffers increases with IP-PIM, since the cells of some packets are switched consecutively. Therefore, IP-PIM causes degradation of the packet loss probability. In this paper, by defining the buffer at which cells that belong to a packet arrive in a certain time slot as an active buffer, we propose a new scheduling algorithm that gives priority to an active buffer so that cells which belong to packets can be switched effectively without increasing the queue length. We evaluate the packet loss probability and the mean packet delay by computer simulations. As a result, it is shown that the proposed scheme can improve the packet loss probability with negligible degradation of the mean packet delay.
Novel selective, potent naphthyl TRPM8 antagonists identified through a combined ligand- and structure-based virtual screening approach (2017)

Transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel, is the predominant mammalian cold temperature thermosensor and it is activated by cold temperatures and cooling compounds, such as menthol and icilin. Because of its role in cold allodynia, cold hyperalgesia and painful syndromes TRPM8 antagonists are currently being pursued as potential therapeutic agents for the treatment of pain hypersensitivity. Recently TRPM8 has been found in subsets of bladder sensory nerve fibres, providing an opportunity to understand and treat chronic hypersensitivity. However, most of the known TRPM8 inhibitors lack selectivity, and only three selective compounds have reached clinical trials to date. Here, we applied two virtual screening strategies to find new, clinics suitable, TRPM8 inhibitors. This strategy enabled us to identify naphthyl derivatives as a novel class of potent and selective TRPM8 inhibitors. Further characterization of the pharmacologic properties of the most potent compound identified, compound 1, confirmed that it is a selective, competitive antagonist inhibitor of TRPM8. Compound 1 also proved itself active in a overreactive bladder model in vivo. Thus, the novel naphthyl derivative compound identified here could be optimized for clinical treatment of pain hypersensitivity in bladder disorders but also in different other pathologies.
The NS1 protein of tick-borne encephalitis virus forms multimeric species upon secretion from the host cell (1994)

Flaviviruses elicit a humoral immune response to two virus-encoded, membrane-associated glycoproteins. One is the major virion surface envelope protein (E), which is recognized by antibody, whereas the other is a secreted, heavily glycosylated non-structural protein (NS1). Inoculation with either protein can give rise to a protective immune response, as can the passive transfer of E and NS1 monospecific monoclonal antibodies. Experiments reported here demonstrate that the secreted form of NS1, whether from cells infected with tick-borne encephalitis virus (TBEV) or from cells infected with a defective recombinant adenovirus containing the NS1 gene, occurs chiefly as a pentamer or hexamer and occasionally as a decamer or dodecamer. Intracellular forms of this protein however occur only as dimers. The higher M(r) forms secreted from the cell are exquisitely sensitive to detergent, suggesting they are held together by hydrophobic bonds. Both intracellular and extracellular forms of the dimer can be dissociated by heat, but at different temperatures. Unlike similar proteins from mosquito-borne viruses. NS1 from TBEV-infected cells cannot be dissociated at ambient temperatures by extremes of pH. Studies on the antigenic structure of this protein show it to have several highly conserved epitopes, confirming similar earlier conclusions from amino acid sequence analyses.
Medication Adherence in the General Population (2012)

The major strengths of our study are a representative sample and a novel approach to assess adherence. Nonadherece seems to be commonplace in the general population. Therefore adherence cannot be expected per se but needs special efforts on behalf of prescribers and public health initiatives. Nonadherence to medication should not only be considered as a drug-specific behaviour problem, but as a behaviour pattern that is independent of the prescribed medication.
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L–A hybrid design approach (2014)

A hybrid-design approach is undertaken to develop a highly potent and selective inhibitor of human cathepsin L. Studies involving human breast carcinoma MDA-MB-231 cells establish that this inhibitor can successfully block intracellular cathepsin L activity, and retard the cell-migratory potential of these highly metastatic cells.
Mutual Recognition and Ethics: A Hegelian Reformulation of the Kantian Argument for the Rationality of Morality (1995)

Reformulation hegelienne de l'argument kantien selon lequel l'autonomie du sujet rationnel est proportionnelle a sa moralite. Se referant au chapitre 4 de la «Phenomenologie de l'esprit», l'A. montre que Hegel apporte la solution aux problemes de l'integration verticale et de l'individuation horizontale qui se posent des lors que l'on recherche la satisfaction de ses propres desirs
Cordyceps fungi: natural products, pharmacological functions and developmental products (2009)

Recent research advances in the study of Cordyceps, including Cordyceps mushrooms, chemical components, pharmacological functions and developmental products, has been reviewed and discussed. Developing trends in the field have also been appraised.
P‐182: Functional Coatings for Display Applications by a Spray Process (2016)

Antiglare coatings were spray coated on plasma treated glass surfaces followed by low temperature curing at 150 °C for 1 hour. The anti‐glare coatings with embedded mono‐dispersed latex particles can reach a pencil hardness of ≥8H, and a gloss range of 40 to 90 GU. In addition, a novel anti‐fingerprint coating was discussed and showed significantly reduced fingerprint visibility and improved easy‐to‐clean properties.
Pengaruh Kreativitas Siswa Terhadap Prestasi Belajar Materi Akuntasi Kelas XI IPS SMA Swasta Islam Muthmainah Ende (2017)

This study aims to find out: (1) Creativity of students of class XI IPS Islamic Senior School Muthmainnah (2) Student achievement class XI IPS Islamic Senior School Muthmainnah (3) The influence of student creativity on student achievement subjects economic accounting material? Creativity of class XI student of IPS Private High School Muthmainnah Ende is in the high category. Indicated by the average value of student creativity (X) of 85.3. Student achievement class XI IPS Private High School Islamic Muthmainnah Ende is in the good category. This is indicated by the average value of learning achievement (Y) of 82.7. From the analysis there is a positive relationship beetwen the influence of student creativity and learning achievement. From result of calculation value = 25.516 bigger than = ± 2.048, it shows that there is influence of student creativity to learning achievement.
Comparison of Volumetric and Material Balance Estimates of Gas-in-place Washington Cockfield "D" Sand Reservoir (1976)

American Institute of Mining, Metallurgical, and Petroleum Engineers, Inc.This paper was prepared for the Improved Oil Recovery Symposium of the Society of Petroleum Engineers of AIME, to be held in Tulsa, Okla., March 22–24, 1976. Permission to copy is restricted to an abstract of not more than 300 words. Illustrations may not be copied. The abstract should contain conspicuous acknowledgment of where and by whom the paper is presented. Publication elsewhere after publication in the JOURNAL paper is presented. Publication elsewhere after publication in the JOURNAL OF PETROLEUM TECHNOLOGY or the SOCIETY OF PETROLEUM ENGINEERS JOURNAL is usually granted upon request to the Editor of the appropriate journal provided agreement to give proper credit is made. provided agreement to give proper credit is made. Discussion of this paper is invited. Three copies of any discussion should be sent to the Society of Petroleum Engineers office. Such discussion may be presented at the above meeting and with the paper, may be considered for publication in one of the two SPE magazines.Abstract. After development of this gas reservoir complete, the volumetric estimate of gas-in place was about 250 M cf. Net gas production place was about 250 M cf. Net gas production during cycling and subsequent blowdown, which reduced pressure in the reservoir from 4590 psig initially to an average pressure of 540 psig, indicates gas actually in place was about 135 M cf. An in-depth review of the reservoir has been made to determine what combination of problems in core analyses, log interpretations, and problems in core analyses, log interpretations, and geologic considerations led to this 85 percent overestimate of gas-in-place.Introduction. The most common method of determining residual oil saturation as a target for improved recovery is to estimate the oil-in-place originally and then to subtract past oil production and reserves remaining with conventional extraction methods. Recently, other techniques such as conventional well logs in new wells drilled into watered out areas, pressure cores, loginject-log techniques, tracer studies, etc., have been used to measure more directly the residual oil saturation in specific reservoirs. Quite often residual oil saturations actually found have been much lower than those estimated by the material balance method.Most volumetric techniques for estimating free gas-in-place initially are identical to those for determining oil-in-place initially. Early pressure-production performance of Cockfield
Post-transcriptional regulation of the human liver/bone/kidney alkaline phosphatase gene (1991)

Osteoblasts express high levels of liver/bone/kidney alkaline phosphatase (LBK AP), an enzyme critical for bone formation. Other tissues and cell types generally express much lower levels of LBK AP and correspondingly lower levels of mRNA. In light of our early observations that the human LBK AP promoter is expressed equally when transfected into a variety of different cells, we have carried out a detailed study of LBK AP gene expression in Saos-2 cells which are osteoblast-derived and express high levels of LBK AP mRNA, and in HepG2 hepatoblastoma cells which express LBK AP mRNA at levels which are approximately 1000-fold lower. Our results indicate that both of these cells utilize the same promoter sequences to initiate transcription of their LBK AP genes at roughly the same rates. Moreover, the stability of cytoplasmic LBK AP mRNA is equal in both cell types. The lack of any apparent buildup of unspliced precursor mRNA in the nucleus of HepG2 cells leads us to the conclusion that splicing (and nuclear export) is equivalent. It is therefore likely that differential expression is controlled at a very early step post-transcription, possibly by sequences that destabilize the nascent RNA in HepG2 cells. We reason that these destabilizing sequences are located in the gene's introns because a transfected LBK AP minigene, comprised of the full length cDNA and flanking sequences, is expressed efficiently in both cell types.
Micromirrors connected in series for low voltage operation in vacuum (2013)

Micromirrors connected in series were fabricated and studied for decreasing operation voltage and investigating an energy loss of resonant mirror. Three identical mirrors (center-mirror and side-mirrors) were connected by torsion bars. The torsion bars of center-mirror were not fixed to substrate; the other sides of the torsion bars of side-mirrors were fixed to the substrate. The motions of the mirrors connected in series were studied. Using the third-mode resonance of series-mirror, the motion of center-mirror was identical to that of a single mirror in the first-mode resonance. The energy loss of mirror was studied by comparing the quality-factors of the series-mirror in the third-mode resonance and the single mirror in the first-mode resonance in vacuum. The quality-factor of the series-mirror was higher than that of the single mirror. The operation voltage of the series-mirror was decreased under the resonant condition in vacuum. The improvements in quality-factor and operation voltage of the series-mirror in the third-mode resonance were explained by the reduced anchor loss due to the virtual supporting of the center-mirror.
Measuring Binding Constants of Cucurbituril-Based Host–Guest Interactions at the Single-Molecule Level with Nanopores (2019)

Cucurbiturils are one type of widely used macrocyclic host compound in supramolecular chemistry. Their peculiar properties have led to applications in a wide variety of research areas such as fluorescence spectroscopy, drug delivery, catalysis, and nanotechnology. However, the solubilities of cucurbiturils are rather poor in water and many organic solvents, which may cause accuracy problems when measuring binding constants with traditional methods. In this report, we aim to develop an approach to measure the binding constants of cucurbituril-based host-guest interactions at the single-molecule level. First, we covalently attach different guest compounds to the side-chain of DNA molecules. Then, excess cucurbiturils are incubated with DNA probes to form the host-guest complexes. Next, the modified DNA hybrids are threaded through α-hemolysin nanopore to generate highly characteristic current events. Finally, statistical analyses of the obtained events afford the binding constants of cucurbiturils with various molecules. This new approach provides a simple and straightforward method to compare binding strength of different host-guest complexes and may find applications for quantifying other macrocycle-based host-guest interactions.
Lipid synthesis in isolated rat hepatocytes: activation by insulin and vanadate and inhibition by ouabain. (1984)

Lipid synthesis from [1-14C] acetate was stimulated by insulin in rat hepatocytes. Vanadate also enhanced lipid synthesis, although its effect was about 2-3 times higher than that of insulin, whereas ouabain significantly decreased hepatic lipid synthesis. The stimulatory effects of both insulin and vanadate were not dependent on extracellular Ca2+. Also, this stimulation was not mimicked by either ouabain or ouabain plus vanadate, even though they are expected to induce a non-specific increase of cytoplasmic Ca2+ concentration. These results suggest that insulin and vanadate stimulation of lipid synthesis may not be mediated by changes in Ca2+ fluxes through plasma membrane.
Quantum technology for a new generation of inertial sensors (2016)

Advances in laser cooling of atoms have produced a new generation of inertial sensors based on matter-wave interferometers, which are becoming an essential technology for accurate positioning or geodesy.
DIFFERENTIAL EFFECT OF HYPERTONIC SALINE DURING HYPOTENSIVE RESUSCITATION IN RATS SUBJECTED TO HEMORRHAGIC/TRAUMATIC SHOCK (HTS) (2006)

Background: Small volume resuscitation with hypertonic saline (HS) is a possible approach to overcome the preclinical phase. Aim: In the present study, we tested the effect of hypotensive resuscitation with HS on hemodynamic parameters, and mitochondrial function in a rat model of HTS. Methods: Rats were subjected to a midline laparotomy, hemorrhage (MAP = 30 - 35 mmHg until decompensation), partial resuscitation with 4 ml/kg of 7.5% NaCl (HS) or normal saline (NS) followed by an infusion ofRinger's solution to maintain MAP at 40-45 mmHg for 40min (hypotensive state). Finally, animals were fully resuscitated with Ringer's solution and shed blood. Results: HTS was associated with a significant reduction inMAP, cardiac index (CI) and stroke volume (SV), which was normalized at the end of resuscitation. Hypotensive resuscitation with HS resulted in significantly lower CI andSV during the permissive hypotensive period (CI: 197 ± 50vs. 129 ± 46 mL/min/kg and SV: 0.22 ± 07 vs. 0.15 ± 05mL/beat). At the same time systemic vascular resistance was, at least trend wise, higher in HS than in NS treated animals (1.94 ± 0.06 vs. 2.71 ± 0.75 mmHg/mL/min/kg).HS treatment prevented the significant increase in creatine kinase and lactate dehydrogenase activity after resuscitation. In addition, the significantly reduced mitochondrial activity in the liver at the end of experiment (133 ± 12 vs. 109 ± 15 nM O2/min/mg, laboratory controls vs. NS group) was prevented by HS treatment (125 ± 13nM O2/min/mg). Conclusion: Our data suggest that HStreatment during hypotensive resuscitation might decrease heart performance but might also improve mitochondrial function thereby preventing secondary organ damage after hemorrhage and resuscitation.
Toxicity of a trivalent organic arsenic compound, dimethylarsinous glutathione in a rat liver cell line (TRL 1215) (2006)

These findings suggest that the significant cytotoxicity induced by DMAs(III)G may not be seen in healthy humans, even if DMAs(III)G is formed in the body from As(III).
ChemInform Abstract: Rh‐Catalyzed Addition of Arylboroxines to Cyclic N‐(Isopropanesulfinyl)ketimines. (2013)

Abstract A wide range of cyclic amine products is available and the sulfinyl group can be smoothly removed.
Model Based Vehicle Tracking for Autonomous Driving in Urban Environments (2008)

Situational awareness is crucial for autonomous driving in urban environments. This paper describes moving vehicle tracking module that we developed for our autonomous driving robot Junior. The robot won second place in the Urban Grand Challenge, an autonomous driving race organized by the U.S. Government in 2007. The tracking module provides reliable tracking of moving vehicles from a high-speed moving platform using laser range finders. Our approach models both dynamic and geometric properties of the tracked vehicles and estimates them using a single Bayes filter per vehicle. We also show how to build efficient 2D representations out of 3D range data and how to detect poorly visible black vehicles. Experimental validation includes the most challenging conditions presented at the UGC as well as other urban settings.
A finite element multifrontal method for 3D CSEM modeling in the frequency domain (2012)

ABSTRACT There has been a recent increase in the use of controlled-source electromagnetic (CSEM) surveys in the exploration for oil and gas. We developed a modeling scheme for 3D CSEM modeling in the frequency domain. The electric field was decomposed in primary and secondary components to eliminate the singularity originated by the source term. The primary field was calculated using a closed form solution, and the secondary field was computed discretizing a second-order partial differential equation for the electric field with the edge finite element. The solution to the linear system of equations was obtained using a massive parallel multifrontal solver, because such solvers are robust for indefinite and ill-conditioned linear systems. Recent trends in parallel computing were investigated for their use in mitigating the computational overburden associated with the use of a direct solver, and of its feasibility for 3D CSEM forward modeling with the edge finite element. The computation of the primary field was parallelized, over the computational domain and the number of sources, using a hybrid model of parallelism. When using a direct solver, the attainment of multisource solutions was only competitive if the same factors are used to achieve a solution for multi right-hand sides. This aspect was also investigated using the presented methodology. We tested our proposed approach using 1D and 3D synthetic models, and they demonstrated that it is robust and suitable for 3D CSEM modeling using a distributed memory system. The codes could thus be used to help design new surveys, as well to estimate subsurface conductivities through the implementation of an appropriate inversion scheme.
Estrogen receptor level determines sex-specific in vitro transcription from the Xenopus vitellogenin promoter. (1990)

Female-specific expression of the Xenopus laevis vitellogenin gene was reconstituted in vitro by addition of recombinant vaccinia-virus-produced estrogen receptor to nuclear extracts from male livers, in which this gene is silent. Transcription enhancement was at least 30 times and was selectively restricted to vitellogenin templates containing the estrogen-responsive unit. Thus, in male hepatocytes, estrogen receptor is the limiting regulatory factor that in the female liver controls efficient and accurate sex-specific expression of the vitellogenin gene. Furthermore, the Xenopus liver factor B, which is essential in addition to the estrogen receptor for the activation of this gene, was successfully replaced in the Xenopus extract by purified human nuclear factor I, identifying factor B of Xenopus as a functional homolog of this well-characterized human transcription factor.
Positive Frequency of Sequences Arising from Neutral Difference Equations (2014)

By making use of frequency measures, in this paper we consider the positive frequency of sequences, which is produced by a class of neutral difference equations. The last example shows that our results are feasible.
Polyisoprenylated Cysteinyl Amide Inhibitors Deplete K-Ras and Induce Caspase-dependent Apoptosis in Lung Cancer Cells (2019)

Background: Non-small cell lung cancers (NSCLC) harboring mutation-induced dysregulation of Ras signaling present some of the most difficult-to-manage cases, since directly targeting the constitutively active mutant Ras proteins has not resulted in clinically useful drugs. Therefore, modulating Ras activity for targeted treatment of cancer remains an urgent healthcare need. Objective: In the current study, we investigated a novel class of compounds, the polyisoprenylated cysteinyl amide inhibitors (PCAIs), for their anticancer molecular mechanisms using the NSCLC cell panel with K-Ras and/or other mutant genes. Methods: The effect of the PCAIs on intracellular K-Ras levels, cell viability, apoptosis, spheroid and colony formation were determined. Results: Treatment of the lung cancer cells with the PCAIs, NSL-RD-035, NSL-BA-036, NSL-BA- 040 and NSL-BA-055 resulted in concentration-dependent cell death in both K-Ras mutant (A549, NCI-H460, and NCI-H1573), N-Ras mutant (NCI-H1299) and other (NCI-H661, NCI-H1975, NCIH1563) NSCLC cells. The PCAIs at 1.0 -10 μM induced the degeneration of 3D spheroid cultures, inhibited clonogenic cell growth and induced marked apoptosis via the extrinsic pathway. The most potent of the PCAIs, NSL-BA-055, at 5 μM induced a seven-fold increase in the activity of caspase- 3/7 and a 75% selective depletion of K-Ras protein levels relative to GAPDH in A549 cells that correlated with PCAIs-induced apoptosis. NSL-BA-040 and NSL-BA-055 also induced the phosphorylation of MAP kinase (ERK 1/2). Conclusion: Taken together, PCAIs may be potentially useful as targeted therapies that suppress NSCLC progression through disruption of Ras-mediated growth signaling.