gebhart/patrepeval huggingface dataset:
Managing os/400 with operations navigator v5r1 volume 5: performance management (2003)

Graphical monitoring and managing of your system's performance Monitoring and managing your job's performance Viewing your system's performance history OS/400 Operations Navigator is the graphical interface to manage your IBM eServer iSeries runtime environment. Operations Navigator contains major function and interface enhancements over previous releases. This IBM Redbook explains the performance management capabilities through Operations Navigator interfaces. This is the fifth volume in the OS/400 with Operations Navigator V5R1 series, further explaining performance management capabilities as they were introduced in Managing OS/400 with Operations Navigator V5R1, Volume 1: Overview and More, SG24-6226. This redbook describes and provides examples of the following Management Central performance management-related capabilities: - System Monitors (observing real-time system-wide performance metrics) - Job Monitors (observing real-time job-specific performance metrics) - Graph History (observing historical performance metric summary information) - Collection Services (the underlying performance data collection function that supports the monitor and graph history functions as well as input to the Performance Tools for iSeries, 5722-PT1, licensed product functions) - Management Central - Pervasive (Java servlets supporting many of the Management Central System, Job, and Message monitoring functions as well as managing Integrated xSeries Servers via a remote device browser-based product such as a Personal Digital Assistant (PDA) device) An appendix summarizes V5R2 iSeries Navigator performance management-based enhancements.
On Hitting Times for General Quantum Markov Processes (2022)

Random walks (or Markov chains) are models extensively used in theoretical computer science. Several tools, including analysis of quantities such as hitting and mixing times, are helpful for devising randomized algorithms. A notable example is Schöning's algorithm for the satisfiability (SAT) problem. In this work, we use the density-matrix formalism to define a quantum Markov chain model which directly generalizes classical walks, and we show that a common tools such as hitting times can be computed with a similar formula as the one found in the classical theory, which we then apply to known quantum settings such as Grover's algorithm.
International Life Writing (2013)

Introduction Paul Longley Arthur 1. Tense and Tender Ties: Reflections on Lives Recovered from the Intimate Frontier of Empire and Slavery Cassandra Pybus 2. The Politics of Writing Convict Lives: Academic Research, State Archives and Family History Lucy Frost 3. The Murderer and His Victim: Tracing a Lost Convict of the Botany Bay Decision Emma Christopher 4. Narratives of Natural History: Recovering Lost Lineages in Margaret Levyns' Life-Writing Brett M. Bennett 5. The Theology of Materialism: Redeeming the Natural Religion of Robert Chambers and Vestiges Angela Smith 6. Fiction and Testimony in Don DeLillo's Falling Man Jen Webb 7. Recovering Lives Through Art: Hidden Histories and Commemoration in the Works of Katsushige Nakahashi and Dadang Christanto Caroline Turner and Glen St John Barclay 8. Recovering Ocean Island Katerina Martina Teaiwa 9. Unearthing the Past: Dwikozy Revisited Paul Longley Arthur
358. Gene Transfer to the Airway Epithelium Mediated by a Third Generation HIV-1 Based Vector: Efficiency and Role of Heparan Sulfate (2005)

HIV-1 derived lentiviral (LV) vectors seem to be promising vehicles for gene transfer to the airway epithelium since they integrate in the host genome of non-dividing cells ensuring long-term expression of the transgene. Previous studies have shown that LV vectors could transduce the airway epithelium in vivo from the apical surface, only when tight junctions are disrupted or LV are pseudotyped with heterologous envelopes other than glycoprotein G of the vesicular stomatitis virus (VSV-G). Our study was aimed to investigate the efficiency of an improved VSV-G pseudotyped lentiviral vector, which contains the central polypurine tract (cPPT) and the Woodchuck post-translational regulatory elements, in human respiratory cells and in the murine lung. The vector PPT-GFP was injected intratracheally in C57BL/6 mice at the dose of 4.5|[times]|10E6 TU. After 48 hours, lungs were fixed in paraformaldehyde and cryosections stained with an antibody against GFP. Results show that PPT-GFP transduced the murine airway epithelium in the bronchial and alveolar compartments. Transgene expression was observed also after two weeks of infection with a LV dose of 1|[times]|10E8 TU. Hystological analysis showed no evidence of tissue damage in the lung, suggesting that this LV vector is not cytotoxic. Since heparan sulfate (HS) has been described to mediate infection by VSV-G-pseudotyped retroviral vectors and HIV-1, the expression of this glycosaminoglycan by human respiratory cells and its involvement in LV-mediated gene transfer were studied. Human bronchial epithelial cells (16HBE) and CF tracheal epithelial cells (CFT1) were analyzed for HS expression by flow cytometry and confocal microscopy. HS was expressed by 85-88% of cells, the expression being much stronger on the basolateral side in polarized epithelial cells. To correlate the efficiency of LV mediated transduction with HS expression, polarized CFT1 cells were infected with the lentivirus and some samples were pre-incubated with EGTA (Ethylene glycol-O,O-bis-[2-amino-ethyl]-N,N,N,N,-tetraacetic acid), which disrupts the epithelial tight junctions and allows the LV particles to access the basolateral side of the epithelium. Analysis of GFP expression by FACS indicates that the pre-conditioning increased the transduction efficiency, being the percentage of positive cells of 55%, when the infection was performed without pretreatment, and 71% when the cells were incubated with EGTA. To evaluate the interaction between glycosaminoglycans expressed on the apical surface and lentiviral particles, the LV vector was pre-incubated with heparin and then incubated with 16HBE cells. Heparin determined a dose-dependent inhibition of transduction efficiency up to 65% of untreated vector. Our study shows that 1) The PPT-GFP vector transduce murine airways and human polarized cells, without requirement of disruption of the epithelial barrier integrity and without cytotoxicy 2) HS might be a receptor involved in VSV-G-pseudotyped LV-mediated gene transfer.
Management of scapholunate advanced collapse and scaphoid nonunion advanced collapse without proximal row carpectomy or four corner fusion (2020)

Four corner arthrodesis and proximal row carpectomy are the most common techniques for the management of advanced radiocarpal arthritis due to longstanding scapholunate instability and scaphoid nonunion. The advantages and short comings of each technique have been well defined in the literature. Advancements in joint replacement and arthroscopic surgery have resulted in new operations to manage radiocarpal and midcarpal arthritis. Most of these new procedures are modifications of the two classical operations, but some use modern implants and newer materials. New individualized options, like osteochondral grafting in combination with proximal row carpectomy or (arthroscopic) distal resection of the scaphoid, allowed us to improve our treatment and offer patients less invasive but equally effective procedures. We consider that four corner arthrodesis and proximal row carpectomy should not always be standard management for advanced radiocarpal arthritis.
Determining the Solubility of Organic Compounds in Supercritical Carbon Dioxide Using Supercritical Fluid Chromatography Directly Interfaced to Supercritical Fluid Solubility Apparatus (2016)

The solubilities of benzoin and 3,3′,4,4′-benzophenonetetracarboxylic dianhydride in supercritical fluid carbon dioxide have been measured using static supercritical fluid solubility apparatus directly interfaced to supercritical fluid chromatography (SFC). The method involves increasing the pressure of supercritical fluid carbon dioxide in controlled steps to produce a series of saturated sample solutions that are sequentially analyzed by online SFC. The system requires minimal manual sample manipulation stages and facilitates a self-validation check procedure. Solubility data for benzoin was determined at 308 and 318 K through the pressure range of 12–24 MPa using 2 MPa steps. Solubility data for 3,3′,4,4′-benzophenonetetracarboxylic dianhydride was determined at 328 and 343 K through the pressure range 15–27.5 MPa using 2.5 MPa steps. The Mendéz-Santiago and Teja model has been successfully applied to correlate all sets of experimental solubility data.
Groundwater in fractured bedrock environments: managing catchment and subsurface resources – an introduction (2019)

Hard rocks, including crystalline igneous, metamorphic and strongly cemented sedimentary and carbonate rocks, cover about 50% of the Earth's land surface (Singhal & Gupta 2010). Globally, the volume of groundwater contained in hard rock aquifers is not well constrained (Comte et al. 2012) but locally they can be important aquifers (MacDonald et al. 2012), albeit with low groundwater storage and poor primary porosity and permeability. Groundwater flow in these hard rocks is commonly observed to be associated with water-bearing discontinuities, such as fractures, joints and faults (Mazurek 2000; Berkowitz 2002; Font-Capo et al. 2012), and in the weathered regolith (Wright 1992; Chilton & Foster 1995; Deyassa et al. 2014). Structural elements such as fault zones also strongly govern the behaviour of these systems (Forster & Evans 1991; Lopez & Smith 1995; Bense et al. 2013). The nature, abundance, orientation and connectivity of these water-bearing features are largely governed by the history and nature of structural deformation of the bedrock, and commonly impose strong anisotropic flow and transport parameters on these bedrock aquifers (Hsieh et al. 1985; Bour & Davy 1997; Mortimer et al. 2011). Weathering processes furthermore lead to an alteration of bedrock composition and associated aquifer properties resulting in enhanced fracture connectivity and an overall vertical stratification/zonation of bulk aquifer properties, ranging from highly altered shallow regolith horizons to more competent sparsely fractured bedrock at depth (Dewandel et al. 2006; Krasný & Sharp 2007; Lachassagne et al. 2011).
Baits as a tool for population control of the formosan subterranean termite (2003)

Localized application of arsenic dust was one of the preferred approaches for population control of subterranean termites in the late 1800s to early 1900s in the United States. In the 1950s when the long-lasting and inexpensive cyclodienes were registered, soil barrier treatments become the standard technique for the termite control industry. Because of the large colony size, application of soil termiticides beneath a structure usually does not impact C. formosanus colony, and the surviving colony continues to produce alates and foragers that further infest nearby areas. Following the discovery of molting inhibitory effects of hexaflumuron against subterranean termites in the late 1980s, numerous field studies demonstrated that colonies of C. formosanus could be eliminated by application of hexaflumuron baits. Although it has been established that baits can be used to kill colonies of C. formosanus, there is a need to implement a program to manage C. formosanus populations in a large area.
Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium yoelii liver stage (2021)

Both subunit and attenuated whole-sporozoite vaccination strategies against Plasmodium infection have shown promising initial results in malaria-naive westerners but less efficacy in malaria-exposed individuals in endemic areas. Here, we demonstrate proof of concept by using a rodent malaria model in which non-neutralizing antibodies (nNAbs) can directly interfere with protective anti-circumsporozoite protein (CSP) humoral responses. We characterize a monoclonal antibody, RAM1, against Plasmodium yoelii sporozoite major surface antigen CSP. Unlike the canonical PyCSP repeat domain binding and neutralizing antibody (NAb) 2F6, RAM1 does not inhibit sporozoite traversal or entry of hepatocytes in vitro or infection in vivo. Although 2F6 and RAM1 bind non-overlapping regions of the CSP-repeat domain, pre-treatment with RAM1 abrogates the capacity of NAb to block sporozoite traversal and invasion in vitro. Importantly, RAM1 reduces the efficacy of the polyclonal humoral response against PyCSP in vivo. Collectively, our data provide a proof of concept that nNAbs can alter the efficacy of malaria vaccination.
A nano-tensile tester for creep studies (2011)

Free-standing metallic thin films are increasingly used as structural components in MEMS. In commercial devices, long-term reliability is essential, which requires determining time-dependent mechanical properties of these films. The uniaxial tensile test is a preferred method due to uncomplicated determination of the stress and strain state. However, at the MEMS-scale this method is not straightforward: specimen handling and loading, force and deformation measurement need careful consideration. Here we discuss the challenges of the application and measurement of nano-Newton forces, nanometer deformations and micro-radians rotation alignment ensuring negligible bending in on-chip tensile test structures during long periods. We then present a novel tensile-testing instrument with in-situ capabilities in SEM and Optical Profilometry. The design solutions to measure these small forces and deformations whilst ensuring a uniaxial stress state will be presented.
Immunofluorescent localization of antithrombin III in human skin (1982)

The presence in clinically normal human skin of the proteinase inhibitor antithrombin III (ATIII) has been studied by indirect immunofluorescence (IF) microscopy. The IF staining reaction for ATIII in skin tissue sections was most prominent in vessel wall structures. The simultaneous use of fluorescent staining techniques for nuclear DNA revealed that ATIII antigen tends to be concentrated at the level of the vascular endothelial basement membrane, in contrast to the typical intra-endothelial distribution of Factor VIII related antigen. Although our findings indicate that ATIII is normally associated with dermal vessel walls, it remains to be seen whether its presence there is of importance, e.g. in modulating inflammatory skin responses.
Nearest neighbor voting in high dimensional data: Learning from past occurrences (2012)

Hubness is a recently described aspect of the curse of dimensionality inherent to nearest-neighbor methods. This paper describes a new approach for exploiting the hubness phenomenon in k-nearest neighbor classification. We argue that some of the neighbor occurrences carry more information than others, by the virtue of being less frequent events. This observation is related to the hubness phenomenon and we explore how it affects high-dimensional k-nearest neighbor classification. We propose a new algorithm, Hubness Information k-Nearest Neighbor (HIKNN), which introduces the k-occurrence informativeness into the hubness-aware k-nearest neighbor voting framework. The algorithm successfully overcomes some of the issues with the previous hubness-aware approaches, which is shown by performing an extensive evaluation on several types of high-dimensional data.
Farce and Michael Frayn (1983)

"Is God?", asks Professor George Moore in Stoppard's Jumpers. "Is farce?" might be a question for today's theatre and for the same reason that bothers Moore and his wife, Dotty, in their speculation on God. How can farce exist in a society which has lost all its certainties and loosened all the rigid social and moral structures which were the launching pad for the farces of the past? The special pleasure of the form, as Eric Bentley has said, is that "Inhibitions are momentarily lifted, repressed thoughts are admitted into consciousness, and we experience that feeling of power and pleasure, generally called elation". But how if society is busy encouraging us not to repress but to express and feel free? It may be an illusion, but the assumption that freedom is our ambience does present problems for the farce writer looking for something fixed and solid to support the wild balancing acts which are the special triumph of the form.
Regulation of raft‐dependent endocytosis (2007)

Raft-dependent endocytosis is in large part defined as the cholesterol-sensitive, clathrin-independent internalization of ligands and receptors from the plasma membrane. It encompasses the endocytosis of caveolae, smooth plasmalemmal vesicles that form a subdomain of cholesterol and sphingolipid-rich lipid rafts and that are enriched for caveolin-1. While sharing common mechanisms, like cholesterol sensitivity, raft endocytic routes show differential regulation by various cellular components including caveolin-1, dynamin-2 and regulators of the actin cytoskeleton. Dynamin-dependent raft pathways, mediated by caveolae and morphologically equivalent non-caveolin vesicular intermediates, are referred to as caveolae/raft-dependent endocytosis. In contrast, dynamin-independent raft pathways are mediated by non-caveolar intermediates. Raft-dependent endocytosis is regulated by tyrosine kinase inhibitors and, through the regulation of the internalization of various ligands, receptors and effectors, is also a determinant of cellular signaling. In this review, we characterize and discuss the regulation of raft-dependent endocytic pathways and the role of key regulators such as caveolin-1.
The Race for Dominance: OLED or LCOS Microdisplays in Augmented and Virtual Reality (2018)

When I was invited to be the guest editor of this edition of Information Display, display engines for augmented reality (AR) and virtual reality (VR) came to mind, as this topic continues to be the subject of hot debate in our industry. I have colleagues residing in different camps with regard to which microdisplay will be the dominant player in this escalating market, so I reached out to Barry Young and Po King Li, both highly respected technical experts in the field who have different opinions on the subject. Our own work at Luminit leverages both of these technologies, along with LED-and laser-illuminated MEMs devices, and so we are more than a passive stakeholder in this race for dominance. Barry Young's article, "OLED Displays and the Immersive Experience," offers a realistic view of the challenges facing the industry in creating a truly enveloping AR or VR experience. He notes that while augmented-and virtual-reality consumer products may give famous CEOs a lot of buzz, end-user acceptance is lagging, due largely to price and the awkward and bulky headsets currently available. In spite of the hardware and software challenges, however, he emphasizes the advantages of OLED microdisplays for creating a truly immersive VR experience. Advantages in latency, contrast ratio, response time, and black levels, he notes, as well as advancements in luminance, make OLED microdisplays ideal for both VR and AR.
Advances in Boston Keratoprosthesis: Enhancing Retention and Prevention of Infection and Inflammation (2007)

Khan, Bilal F. MD; Harissi-Dagher, Mona MD; Khan, Danish M. MD; Dohlman, Claes H. MD, PhD Author Information
Effector CD4 T cells with stem cell-like properties mediate chronic intestinal inflammation (2017)

Abstract Increased IFNγ production is a hallmark of mucosal CD4 T cells in inflammatory bowel disease (IBD) patients; however, the role of this cell population in intestinal inflammation remains controversial. To elucidate this, viable IFNγ producing and non-producing CD4 T cells were isolated from mice with colitis and examined for the ability to confer disease. Paradoxical to the proinflammatory nature of IFNγ, CD4 T cells producing IFNγ cause attenuated pathology upon transfer, while IFNγ non-producing cells result in severe intestinal inflammation. The pathogenic IFNγ non-producing cells exhibit a “"stem cell-like"” gene expression pattern, maintaining genes associated with multipotency including Sell, Tcf7, Lef1, Klf2, and Wnt10a. Consistent with the “stem cell-like” gene signature, IFNγ non-producing CD4 T cells show higher cell survival, superior mitochondrial function, as well as functional plasticity. Conversely, IFNγ producing CD4 T cells express terminal differentiation markers, such as Klrg1, Tim3, Zeb2 and Prdm1, and are more susceptible to cell death. These divergent phenotypes correlate with the glycosyltransferase ST6Gal1. IFNγ nonproducing cells maintain higher levels of St6gal1 mRNA during colitis, while IFNγ producing cells downregulate St6gal1 gene expression. Furthermore, when IFNγ nonproducing cells lose ST6Gal1 activity, they become terminally differentiated, more susceptible to apoptosis and less pathogenic compared to IFNγ nonproducing cells with high ST6Gal1 activity. Together, these data indicate that effector CD4 T cells exist in a spectrum of differentiation states during IBD, from stem cell-like to terminally differentiated, which are associated with IFNγ production and ST6Gal1 activity.
Electrochemistry of Liquid-Liquid Interfaces (2023)

The electrified interface is an important aspect of all heterogeneous chemical systems. It is a vital feature of many biochemical systems as well as of other less complex systems, including, for example, colloids, gels, artificial membranes, and metal-electrolyte interfaces. Steady-state mesurements were carried out in Japan by Watanabe and co-workers, who investigated a wide range of surface-active agents at the water-methyl isobutyl ketone, water-butanol, and water-pentanol interfaces. This chapter shows the relationships between the quantities and the current ideas on the possible physical pictures of the ITIES. The amount of data for ionic standard Gibbs energy of transfer or partition is still rather limited. During the recent years, the model of ionic solvation of Abraham and Liszi has been used for this type of prediction.
Longitudinal Changes in Magnetic Resonance Spectroscopy in Pediatric Concussion: A Pilot Study (2019)

<b>Background:</b> Nearly 20% of US adolescents report at least one lifetime concussion. Pathophysiologic models suggest that traumatic biomechanical forces caused by rotational deceleration lead to shear stress, which triggers a neurometabolic cascade beginning with excitotoxicity and leading to significant energy demands and a period of metabolic crisis for the injured brain. Proton magnetic resonance spectroscopy (<sup>1</sup>H MRS) offers a means for non-invasive measurement of neurometabolic changes after concussion. <b>Objective:</b> Describe longitudinal changes in metabolites measured <i>in vivo</i> in the brains of adolescent patients with concussion. <b>Methods:</b> We prospectively recruited 9 patients ages 11 to 20 who presented to a pediatric Emergency Department within 24 h of concussion. Patients underwent MRI scanning within 72 h (acute, <i>n</i> = 8), 2 weeks (subacute, <i>n</i> = 7), and at approximately 1 year (chronic, <i>n</i> = 7). Healthy, age and sex-matched controls were recruited and scanned once (<i>n</i> = 9). <sup>1</sup>H MRS was used to measure N-acetyl-aspartate, choline, creatine, glutamate + glutamine, and myo-inositol concentrations in six regions of interest: left and right frontal white matter, posterior white matter and thalamus. <b>Results:</b> There was a significant increase in total thalamus glutamate+glutamine/choline at the subacute (<i>p</i> = 0.010) and chronic (<i>p</i> = 0.010) time points, and a significant decrease in total white matter myo-inositol/choline (<i>p</i> = 0.030) at the chronic time point as compared to controls. <b>Conclusion:</b> There are no differences in <sup>1</sup>H MRS measurements in the acute concussive period; however, changes in glutamate+glutamine and myo-inositol concentrations detectable by <sup>1</sup>H MRS may develop beyond the acute period.