gebhart/patrepeval huggingface dataset:
Giant Bilateral Renal Angiomyolipomas and Lymphangioleiomyomatosis Presenting after Two Successive Pregnancies Successfully Treated with Surgery and Rapamycin (2011)

We report the case of a 25-year-old woman who presented with abdominal and flank pain with two successive pregnancies and was diagnosed of giant bilateral renal AMLs and pulmonary LAM associated with TSC in the post-partum of her second pregnancy. This case illustrates that in women with TSC rapid growth from renal AMLs and development of LAM may occur with successive pregnancies. It also stresses the potential for preservation of renal function despite successive bilateral renal surgery of giant AMLs. Moreover, the treatment with a low-dose rapamycin may be an option for LAM treatment. Finally, a low-dose rapamycin may be considered as an adjuvant treatment together to kidney-sparing conservative surgery for renal AMLs.
Claisen‐Type Condensation of Vinylogous Acyl Triflates. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Multiple Pinch-Off Points in Memristive Equations: Analysis and Experiments (2019)

Pinched hysteresis behavior is considered evidence of the existence of the memristive element. Recently, the multilobes (more than two) behavior has been discovered in some memristive devices. In this paper, a fractional-order flux/voltage-controlled memristive model is introduced that is able to develop multiple symmetric and asymmetric pinch-off points. Generalized closed-form expressions for the necessary conditions of multiple pinch-off points existence are derived in addition to the coordinates of the pinch-off points in the I - V plane. Closed-form expressions for the minimum and maximum achievable resistances are derived. Moreover, different illustrative numerical examples have been given verifying the calculated expressions. Finally, in order to verify the multiple pinch-off behaviors, the proposed emulator circuit is introduced, analyzed, and verified using both SPICE simulations and experiments to validate the proposed models. Different fractional-order cases have been experimentally tested using different excitation signals such as sinusoidal, square, and triangular signals showing the circuitability to generate the multiple pinch-off points.
Vitamin B12status in health and disease: a critical review. Diagnosis of deficiency and insufficiency – clinical and laboratory pitfalls (2021)

Vitamin B<sub>12</sub> (cobalamin) is an essential cofactor for two metabolic pathways. It is obtained principally from food of animal origin. Cobalamin becomes bioavailable through a series of steps pertaining to its release from dietary protein, intrinsic factor-mediated absorption, haptocorrin or transcobalamin-mediated transport, cellular uptake, and two enzymatic conversions (<i>via</i> methionine synthase and methylmalonyl-CoA-mutase) into cofactor forms: methylcobalamin and adenosylcobalamin. Vitamin B<sub>12</sub> deficiency can masquerade as a multitude of illnesses, presenting different perspectives from the point of view of the hematologist, neurologist, gastroenterologist, general physician, or dietician. Increased physician vigilance and heightened patient awareness often account for its early presentation, and testing sometimes occurs during a phase of vitamin B<sub>12</sub> insufficiency before the main onset of the disease. The chosen test often depends on its availability rather than on the diagnostic performance and sensitivity to irrelevant factors interfering with vitamin B<sub>12</sub> markers. Although serum B<sub>12</sub> is still the most commonly used and widely available test, diagnostics by holotranscobalamin, serum methylmalonic acid, and plasma homocysteine measurements have grown in the last several years in routine practice. The lack of a robust absorption test, coupled with compromised sensitivity and specificity of other tests (intrinsic factor and gastric parietal cell antibodies), hinders determination of the cause for depleted B<sub>12</sub> status. This can lead to incorrect supplementation regimes and uncertainty regarding later treatment. This review discusses currently available knowledge on vitamin B<sub>12</sub>, informs the reader about the pitfalls of tests for assessing its deficiency, reviews B<sub>12</sub> status in various populations at different disease stages, and provides recommendations for interpretation, treatment, and associated risks. Future directions for diagnostics of B<sub>12</sub> status and health interventions are also discussed.
NMR and ESR study of the conformations and dynamical properties of poly(L-lysine) in aqueous solutions (1981)

International audience
Use of Molybdates for Estimating Amount of Olefinic-Type Hydrocarbons in Air (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUse of Molybdates for Estimating Amount of Olefinic-Type Hydrocarbons in AirR. D. MacPheeCite this: Anal. Chem. 1954, 26, 1, 221–225Publication Date (Print):January 1, 1954Publication History Published online1 May 2002Published inissue 1 January 1954https://pubs.acs.org/doi/10.1021/ac60085a040https://doi.org/10.1021/ac60085a040research-articleACS PublicationsRequest reuse permissionsArticle Views18Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Scattering of electromagnetic waves by charged spheres: near-field external intensity distribution (2012)

This Letter treats the scattering of electromagnetic waves by an electrically charged spherical particle in near-field approximation. Particular attention is paid to the external intensity distribution at the outer edges of the particle. The difference between scattering by a charged sphere and an electrically neutral sphere is significant only when size parameters exceed unity.
Toward a Cohesive Theory of Polymerization Volume Change, 1 (2005)

Abstract Summary: Rational design of polymer‐based composites must include an understanding of how and why polymerization volume change occurs. Computational chemistry methods offer significant leverage in such processes. An obstacle to their use has been the meager amount of systematic volume change data collected under the same conditions and using the same methods. This work provides volume change data for eight oxiranes using the mercury dilatometry method. Densities of pure monomers are often unknown for newly synthesized compounds, but are required for the correction of the composite to monomer volume change. The densities have been estimated here by the application of a newly‐developed quantum mechanically‐based quantitative structure property relationship (QMQSPR). This computational chemistry model can be used to estimate densities of a large array of organic compounds with sufficient accuracy for most routine purposes. These results are presented herein. Correspondence between experimental and QMQSPR calculated results for densities. image Correspondence between experimental and QMQSPR calculated results for densities.
Preparation of β-Amino Esters and β-Lactams from Nitriles via Aldimine-Borane Complexes (2010)

A one-pot synthesis of β-amino esters has been achieved in 59-75% yield from aromatic and aliphatic nitriles via the condensation of the corresponding non-enolizable and enolizable aldimine-triethylborane complexes, respectively with methyl trimethylsilyl ketene acetals.Grignard-mediated lactamization of the intermediate β-amino esters provides the corresponding -lactams in the same pot in 58-74% overall yield.The first synthesis of a β-lactam (azetidin-2-one) was reported a century ago by Staudinger via the [2+2]-cycloaddition of diphenylketene with benzylidene aniline. 1 The interest in β-lactam molecules arose when the antibiotic properties of the first semi-synthetic penicillin, Penicillin G, were identified nearly seven decades ago. 2 Since then other families of β-lactam antibiotics have been extensively developed and immensely used throughout the world to fight infectious pathogens. 3β-Lactams also serve as important building blocks for the preparation of various natural and synthetic antibiotics. 4In addition, they also serve as versatile intermediates for the synthesis of a variety of protein and non-protein amino acids, peptides, peptidomimetics, taxoid antitumor agents, heterocycles, and other types of compounds. 5Accordingly, the preparation of α-substituted β-lactams and β-amino acids is a topic of interest to organic and medicinal chemists. 6astereoselective alkylation to introduce substitution at the α-carbon has been an efficient method for the preparation of 3,3-dialkyl substituted β-amino acid derivatives. 7One of the general methods for the preparation of α-alkyl substituted β-lactams is the Staudinger cycloaddition reaction between Schiff bases 8 and ketenes obtained from enantiomerically pure β-silyloxy-or β-(silyl)butyric acid chlorides. 9This paper is dedicated to Prof.
REVIEWS Jean Genet: Criminalité et transcendance. By BICKELGISÈLE A. CHILD. (Stanford French and Italian Studies, 55). Saratoga, California, Anma Libri, 1987. 138 pp. (1990)

REVIEWS Jean Genet: Criminalité et transcendance. By GISÈLE A. CHILD BICKEL. (Stanford French and Italian Studies, 55). Saratoga, California, Anma Libri, 1987. 138 pp. DAVID H. WALKER DAVID H. WALKER KEELE Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume XLIV, Issue 3, July 1990, Pages 363–364, https://doi.org/10.1093/fs/XLIV.3.363 Published: 01 July 1990
Mass spectra of ortho substituted 1‐phenyl‐2‐thioureas (1977)

Abstract The mass spectra of some 1‐( o ‐alkylphenyl)‐2‐thioureas have been investigated and deuterium labelling shows that the proton lost in the SH⋅ abstraction originates from the α‐hydrogens in the o ‐alkyl group. The intensity of the fragment ion formed by loss of the o ‐alkyl group increases with the stability of the corresponding alkyl radical.
Real-time Neural Vision For Vehicle Navigation And Safety (2005)

This paper presents an investigation of the application of image analysis, processing and transmission techniques to vehicle navigation and safety. Orthogonalization neural network architectures are used for complex tasks of real time image processing for purposes of navigation and safety, in situations of vehicle maneuvering in unknown and hazardous environments. Hardware-implemented neural networks are used for image processing and compression/decompression on both ends of a communication link between a Traffic Information Center and vehicle.
A Novel Bipolar Wavelength-Time Coding Scheme for Optical CDMA Systems (2004)

We develop a novel bipolar two-dimensional coding scheme for optical code-division multiple-access (OCDMA) communication systems. The coding scheme is based on complementary spectral amplitude coding of broad-band sources in the wavelength domain and as such enables multi-user operation and bipolar signaling. To significantly increase the number of simultaneous users a spreading sequence in the time domain is imposed on the wavelength domain coding. We analyze the performance of a LAN system based on the proposed coding scheme, and show that the coders can be realized via simple and compact hardware.
Beowulf and the Limits of Literature: 1 (1971)

I am not concerned in this paper to talk about Beowulf for its own sake. I want to take Beowulf as an example of a more general point that seems worth making about literature and in particular about literary studies. It is a point I cannot make directly because if I expressed it in a series of propositions I should be misunderstood. I want to take a number of questions raised by Beowulf , some of which have been discussed in their own right by a series of scholars and with some of which I shall have to take issue: I am not , however, concerned with this or that interpretation of the poem but much more with pointing out certain difficulties in the way of understanding it that do not seem resolvable by conventional methods. I do not believe that these problems are confined to Beowulf but that they are part of the necessary business of understanding any literary work. The difference lies in this: Beowulf is a marginal work from the frontiers of literacy and the beginnings of English society, unlike the works most of us get worked up about which are much more central to our language and our way of life. We must beware of committing what the late R. G. Collingwood called the fallacy of precarious margins—that is arguing from marginal cases as though they were central, but it does seem that marginal situations—as the late Ludwig Wittgenstein has so brilliantly shown—have a power to point to things we take for granted without questioning in more central, more ‘normal’ situations.
Le elettrovalvole e l'interfacciamento elettropneumatico (1994)

Overactive bladder (OAB) is a syndrome causing a sudden and unstoppable need to urinate with significant global prevalence. Several drugs are used to treat OAB; however, they have various side effects. Therefore, new treatment options for OAB are required. A series of novel 5-oxo-<i>N</i>-phenyl-1-thioxo-4,5-dihydro-1<i>H</i>-thiazolo[3,4-<i>a</i>]quinazoline-3-carboxamide derivatives were synthesized and evaluated for their large-conductance voltage- and Ca<sup>2+</sup>-activated K<sup>+</sup> channel activation through a cell-based fluorescence assay and electrophysiological recordings. Several compounds, including a 7-bromo substituent on the heterocyclic system, showed increased channel currents. Among the derivatives, compound <b>12h</b> exhibited potent <i>in vitro</i> activity with a half-maximal effective concentration (EC<sub>50</sub>) of 2.89 μM, good oral pharmacokinetic properties (area under the curve and half-life), and <i>in vivo</i> efficacy in a spontaneously hypertensive rat model.
Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1 (2011)

We have recently shown that inhibition of HRR (homologous recombination repair) by Chk1 (checkpoint kinase 1) inhibition radiosensitizes pancreatic cancer cells and others have demonstrated that Chk1 inhibition selectively sensitizes p53 mutant tumor cells. Furthermore, PARP1 [poly (ADP-ribose) polymerase-1] inhibitors dramatically radiosensitize cells with DNA double strand break repair defects. Thus, we hypothesized that inhibition of HRR (mediated by Chk1 via AZD7762) and PARP1 [via olaparib (AZD2281)] would selectively sensitize p53 mutant pancreatic cancer cells to radiation. We also used 2 isogenic p53 cell models to assess the role of p53 status in cancer cells and intestinal epithelial cells to assess overall cancer specificity. DNA damage response and repair were assessed by flow cytometry, γH2AX, and an HRR reporter assay. We found that the combination of AZD7762 and olaparib produced significant radiosensitization in p53 mutant pancreatic cancer cells and in all of the isogenic cancer cell lines. The magnitude of radiosensitization by AZD7762 and olaparib was greater in p53 mutant cells compared with p53 wild type cells. Importantly, normal intestinal epithelial cells were not radiosensitized. The combination of AZD7762 and olaparib caused G 2 checkpoint abrogation, inhibition of HRR, and persistent DNA damage responses. These findings demonstrate that the combination of Chk1 and PARP1 inhibition selectively radiosensitizes p53 mutant pancreatic cancer cells. Furthermore, these studies suggest that inhibition of HRR by Chk1 inhibitors may be a useful strategy for selectively inducing a BRCA1/2 'deficient-like' phenotype in p53 mutant tumor cells, while sparing normal tissue.
Identification of tumor markers in models of human colorectal cancer using a 19,200-element complementary DNA microarray. (2001)

Metastasis represents a crucial transition in disease development and progression and has a profound impact on survival for a wide variety of cancers. Cell line models of metastasis have played an important role in developing our understanding of the metastatic process. We used a 19,200-element human cDNA microarray to profile transcription in three paired cell-line models of colorectal tumor metastasis. By correlating expression patterns across these cell lines, we have identified 176 genes that appear to be differentially expressed (greater than 2-fold) in all highly metastatic cell lines relative to their reference. An analysis of these genes reiterates much of our understanding of the metastatic process and suggests additional genes, many of previously uncharacterized function, that may be causatively involved in, or at least prognostic of, metastasis. Northern analysis of a limited number of these genes validates the observed pattern of expression and suggests that further investigation and functional characterization of the identified genes is warranted.
Inhibitory effect of intrathecal EGCG on mechanical allodynia and nitric oxide synthase expression in spinal cord in neuropathic pain of rat (2012)

Choi, J. I.; Jeong, H. J.; Lee, H. G.; Kim, W. M.; Bae, H. B.; Yoon, M. H. Author Information
The Effect of Bromine Substitution upon the Ultraviolet Absorption Spectra of α,β-Unsaturated Ketones (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Effect of Bromine Substitution upon the Ultraviolet Absorption Spectra of α,β-Unsaturated KetonesA. L. Nussbaum, O. Mancera, Ralph Daniels, G. Rosenkranz, and Carl DjerassiCite this: J. Am. Chem. Soc. 1951, 73, 7, 3263–3266Publication Date (Print):July 1, 1951Publication History Published online1 May 2002Published inissue 1 July 1951https://pubs.acs.org/doi/10.1021/ja01151a079https://doi.org/10.1021/ja01151a079research-articleACS PublicationsRequest reuse permissionsArticle Views111Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Celecoxib Oral Solution and the Benefits of Self-Microemulsifying Drug Delivery Systems (SMEDDS) Technology: A Narrative Review (2023)

Oral drugs reformulated in SMEDDS have shown accelerated times to peak plasma drug concentrations and increased maximum plasma concentrations, compared with capsules, tablets, or suspensions. SMEDDS technology increases both drug absorption and bioavailability of lipophilic drugs, compared with other formulations. Clinically, this allows the use of lower doses with improved PK profiles without compromising efficacy, as shown with celecoxib oral solution for the acute treatment of migraine.
Influence of Different Carbohydrates on Flavonoid Accumulation in Hairy Root Cultures of Scutellaria baicalensis (2016)

Carbohydrate sources play important roles in energy and growth of plants. Therefore, in this study, we investigated the optimal carbohydrate source in hairy root cultures (HRCs) of Scutellaria baicalensis infected with Agrobacterium rhizogenes strain R1000. The hairy roots were cultured in half-strength B5 liquid medium supplemented with seven different carbohydrates sources (sucrose, fructose, glucose, galactose, sorbitol, mannitol and maltose), each at a concentration of 100 mM, in order to identify the best carbon sources for the production of major flavones, such as wogonin, baicalin and baicalein. Sucrose, galactose and fructose markedly influenced the production of major flavones and were therefore chosen for subsequent experiments. HRC growth and flavone accumulation were examined following culture with 30, 100 and 150 mM sucrose, galactose and fructose, respectively. From these data, 150 mM sucrose was found to be the optimal carbon source for the enhancement of baicalein production and growth of S. baicalensis HRCs. Fructose caused the greatest increase in baicalin accumulation. Additionally, galactose was the optimal carbon source for wogonin production. These results provide important insights into the optimal growth conditions, particularly the appropriate carbohydrate source, for S. baicalensis.
Deficient Grip Force Control in Schizophrenia: Behavioral and Modeling Evidence for Altered Motor Inhibition and Motor Noise (2014)

Whether upper limb sensorimotor control is affected in schizophrenia and how underlying pathological mechanisms may potentially intervene in these deficits is still being debated. We tested voluntary force control in schizophrenia patients and used a computational model in order to elucidate potential cerebral mechanisms underlying sensorimotor deficits in schizophrenia. A visuomotor grip force-tracking task was performed by 17 medicated and 6 non-medicated patients with schizophrenia (DSM-IV) and by 15 healthy controls. Target forces in the ramp-hold-and-release paradigm were set to 5 N and to 10% maximal voluntary grip force. Force trajectory was analyzed by performance measures and Principal Component Analysis (PCA). A computational model incorporating neural control signals was used to replicate the empirically observed motor behavior and to explore underlying neural mechanisms. Grip task performance was significantly lower in medicated and non-medicated schizophrenia patients compared to controls. Three behavioral variables were significantly higher in both patient groups: tracking error (by 50%), coefficient of variation of force (by 57%) and duration of force release (up by 37%). Behavioral performance did not differ between patient groups. Computational simulation successfully replicated these findings and predicted that decreased motor inhibition, together with an increased signal-dependent motor noise, are sufficient to explain the observed motor deficits in patients. PCA also suggested altered motor inhibition as a key factor differentiating patients from control subjects: the principal component representing inhibition correlated with clinical severity. These findings show that schizophrenia affects voluntary sensorimotor control of the hand independent of medication, and suggest that reduced motor inhibition and increased signal-dependent motor noise likely reflect key pathological mechanisms of the sensorimotor deficit.