gebhart/patrepeval huggingface dataset:
Data for "Ultrafast deep-ultraviolet study of photoexcited aqueous Ferrioxalate" (2023)

Data repository for the following publication: A. Duque-Prata*, H.-Y. Chen*, L. Müller, M. Oppermann, M. Puppin, C. Serpa, C. Bostedt and M. Chergui, “<em>Ultrafast deep-ultraviolet study of photoexcited aqueous Ferrioxalate</em>”, submitted to ChemPhotoChem Data are divided in 4 numbered folders, organized as follows:<br> Folder "1 - FeOx_scans": This folder contains the raw data of the 6 TA scans of ferrioxalate in water (3.75 mM) obtained upon pumping at 266 nm (280 µJ cm-2 peak fluence)<br> Folder "2 - Water_scan": This folder contains the raw data of 1 TA scan of pure solvent (water)<br> Folder "3 - Wavelength&amp;Time files": This folder contains a file with the calibrated wavelength and a file with the time steps used for TA experiments<br> Folder "4 - FeOx_UV-Vis" - This folder contains the UV-Vis absorption spectrum of ferrioxalate in water
The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy (2015)

Mesenchymal stem cells (MSCs) are ideal for cell-based therapy in various inflammatory diseases because of their immunosuppressive and tissue repair properties. Moreover, their immunosuppressive properties and low immunogenicity contribute to a reduced or weakened immune response elicited by the implantation of allogeneic MSCs compared with other cell types. Therefore, implantation of allogeneic MSCs may be a promising cell-based therapy. In this review, we first summarize the unique advantages of allogeneic MSCs for therapeutic applications. Second, we critically analyze the factors influencing their therapeutic effects, including administration routes, detection time-points, disease models, differentiation of MSCs in vivo, and timing and dosage of MSC administration. Finally, current approaches to allogeneic MSC application are discussed. In conclusion, allogeneic MSCs are a promising option because of their low immunogenicity and immunosuppressive and tissue repair capabilities. Further investigations are needed to enhance the consistency and efficacy of MSCs when used as a cell-based therapy in inflammatory diseases as well as for tissue repair.
Tabellen (2006)

No AccessFaserverbund-KunststoffeApr 2006TabellenGottfried W. EhrensteinGottfried W. Ehrensteinhttps://doi.org/10.3139/9783446457546.008SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2006Pages: 282-289Print ISBN: 978-3-446-22716-3eISBN: 978-3-446-45754-6 Copyright & Permissions© 2006 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Purification and Characterization of PK-120, a Novel Substrate for Plasma Kallikrein, from Guinea Pig Plasma. (1995)

PK-120 is a novel substrate of plasma kallikrein isolated from human plasma. Western blotting using anti-human PK-120 polyclonal antibodies demonstrated the presence of a PK-120-like protein in guinea pig, rat and mouse plasma. We purified the immunoreactive-120 kDa protein from guinea pig plasma by polyethylene glycol fractionation followed by ion-exchange chromatography using Q-Sepharose, heparin-Sepharose, Mono-Q and gel filtration with TSK G3000. The 120 kDa protein thus isolated was similar to human PK-120 with respect to limited proteolysis by kallikrein, amino acid composition, and the N-terminal amino acid sequence, indicating that the immunoreactive 120 kDa protein was guinea pig PK-120.
Novel perspectives on redox signaling in red blood cells and platelets in cardiovascular disease (2021)

The fundamental physiology of circulating red blood cells (RBCs) and platelets involving regulation of oxygen transport and hemostasis, respectively, are well-described in the literature. Their abundance in the circulation and their interaction with the vascular wall and each other have attracted the attention of other putative physiological and pathophysiological effects of these cells. RBCs and platelets are both important regulators of redox balance harboring powerful pro-oxidant and anti-oxidant (enzymatic and non-enzymatic) capacities. They are also involved in the regulation of vascular tone mainly via export of nitric oxide bioactivity and adenosine triphosphate. Of further importance are emerging observations that these cells undergo functional alterations when exposed to risk factors for cardiovascular disease and during developed cardiometabolic diseases. Under these conditions, the RBCs and platelets contribute to increased oxidative stress by their formation of reactive species including superoxide anion radical, hydrogen peroxide and peroxynitrite. These alterations trigger key changes in the vascular wall characterized by enhanced oxidative stress, reduced nitric oxide bioavailability and endothelial dysfunction. Additional pathophysiological effects are triggered in the heart resulting in increased susceptibility to ischemia-reperfusion injury with impairment in cardiac function. Pharmacological interventions aiming at restoring circulating cell function has been shown to exert marked beneficial effects on cardiovascular function. In this review, we summarize the current knowledge of RBC and platelet biology with special focus on redox biology, their roles in the development of cardiovascular disease and potential therapeutic strategies targeting RBC and platelet dysfunction. Finally, the complex and scarcely understood interaction between RBCs and platelets is discussed.
Modified silicone rubber for use as high voltage outdoor insulators (2005)

Abstract Polymer insulation for outdoor use has become increasingly more important and is expected to dominate the future HV‐outdoor applications. Polymeric insulators were reported to have performed better than porcelain and glass in laboratories and outdoor test sites. This paper reports an experimental investigation concerned with electrical and surface properties of a silicone‐modified polymer in comparison with silicone rubber (SIR), ethylene‐propylene‐diene monomer (EPDM), and alloys of SIR–EPDM. The loss of hydrophobicity of polymeric materials induced by UV, salt spray, and water salinity aging was examined in this work. An ATR–FTIR technique was used to study the surface degradation of polymers occurring during UV aging. Tracking and erosion induced by high‐electrical stresses reduce the lifetime of polymeric materials used for outdoor insulation. The results of standard tests showed that silicone rubber suffers from a deterioration of tracking resistance, caused by the loss of hydrophobicity from the action of water salinity stresses. The silicone‐modified polymer shows good hydrophobicity behavior in environmental conditions and excellent tracking and erosion resistance, as compared to SIR, EPDM, and alloy of SIR–EPDM. © 2005 Wiley Periodicals, Inc. Adv Polym Techn 24:51–61, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/adv.20027
Mean Reversion in Stock Prices: Evidence and Implications (1987)

This paper analyzes the statistical evidence bearing on whether transitory components account for a large fraction of the variance in common stock returns.
Modelling shape distortions in composite products (2004)

Shape distortions often occur after the forming of woven fabric reinforced composite products. The thermomechanical behaviour of the product must be known in order to predict these product distortions. A two-step strategy is proposed to model the thermomechanical behaviour of a product. First, the fibre reorientation during processing is predicted, including the process induced fibre stresses. Secondly, a Classical Laminate Theory based model accounts for the locally changed thermomechanical properties of the composite. The strategy is demonstrated with a hemispherical product.
Calculation of rapid heating of a polydisperse coal charge with allowance for physicon chemical transformations of coal substance (1983)

A method is given for calculating the kinetics of the heating of a polydisperse coal charge in a flowing gaseous dispersion. The coagulation and comminution of the particles in collisions, the loss of mass with a rise in the temperature, the passage of the particles into the plastic state, their swelling, etc., have been taken into account.
5G Multiscale Mobility : A Look at Current and Upcoming Models in the Next Technology Era (2018)

The forthcoming fifthgeneration (5G) mobile wireless system is likely to lead to an increasingly heterogeneous data-demand pattern, including a small number of high-data-rate mobile broadband links and a large number of low-data-rate Internet of Things (IoT) applications. Aspects that govern seamless mobility between different access technologies, cell tiers, cell sectors, and frequency bands will be sensitive to the mobility model of the people, their devices, and the machines. An understanding of such entities will play a fundamental role in the future standardization and exploitation of the 5G technologies. In this article, we provide a comprehensive and general overview about existing mobility models that are useful to characterizing movement patterns across multiple distance and population scales. In doing so, all the models are critically discussed, providing strengths and weaknesses. Finally, open issues and critical design choices are highlighted to serve as guidelines for future research on this topic.
Three Complement-Type Repeats of the Low-Density Lipoprotein Receptor-Related Protein Define a Common Binding Site for RAP, PAI-1, and Lactoferrin (1998)

The low-density lipoprotein receptor-related protein (LRP) is a 600-kD scavenger receptor that binds a number of protein ligands with high affinity. Although some ligands do not compete with each other, binding of all is uniformly blocked by the 39-kD receptor-associated protein (RAP). RAP is normally found in the endoplasmic reticulum and seems to function as a chaperone for LRP. To identify the binding sites for RAP, lactoferrin, and plasminogen activator inhibitor-1 (PAI-1), a bacterial expression system has been developed to produce soluble LRP fragments spanning residues 783-1399. These residues overlap most of the CNBr fragment containing the second cluster of complement-type repeats (C). Solid phase binding assays show that 125I-RAP binds to fragments containing three successive complement-type repeats: C5-C7. PAI-1 and lactoferrin bind to the same fragments. A fragment containing C5-C7 also blocks uptake and degradation of 125I-RAP by fibroblasts in a concentration-dependent manner. Binding competition experiments show that RAP, PAI-1, and lactoferrin each inhibit the binding of the others, suggesting that at this site in LRP, RAP acts as a competitive, rather than an allosteric, inhibitor of PAI-1 and lactoferrin binding. © 1998 by The American Society of Hematology.
Platelet-derived Growth Factor Activates p38 Mitogen-activated Protein Kinase through a Ras-dependent Pathway That Is Important for Actin Reorganization and Cell Migration (1999)

Members of the mitogen activated protein (MAP) kinase family, extracellular signal-regulated kinase, stress-activated protein kinase-1/c-Jun NH2-terminal kinase, and p38, are central elements that transduce the signal generated by growth factors, cytokines, and stressing agents. It is well known that the platelet-derived growth factor (PDGF) activates extracellular signal-regulated kinase, which leads to cellular mitogenic response. On the other hand, the role of the other MAP kinases in mediating the cellular function of PDGF remains unclear. In the present study, we have investigated the functional role of the other MAP kinases in PDGF-mediated cellular responses. We show that ligand stimulation of PDGF receptors leads to the activation of p38 but not stress-activated protein kinase-1/c-Jun NH2-terminal kinase. Experiments using a specific inhibitor of p38, SB203580, show that the activation of p38 is required for PDGF-induced cell motility responses such as cell migration and actin reorganization but not required for PDGF-stimulated DNA synthesis. Analyses of tyrosine residue-mutated PDGF receptors show that Src homology 2 domain-containing proteins including Src family kinases, phosphatidylinositol 3-kinase, the GTPase-activating protein of Ras, the Src homology 2 domain-containing phosphatase SHP-2, phospholipase C-gamma, and Crk do not play a major role in mediating the PDGF-induced activation of p38. Finally, the expression of dominant-negative Ras but not dominant-negative Rac inhibited p38 activation by PDGF, suggesting that Ras is a potent mediator in the p38 activation pathway downstream of PDGF receptors. Taken together, our present study proposes the existence of a Ras-dependent pathway for the activation of p38, which is important for cell motility responses elicited by PDGF stimulation.
The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation (2018)

Superoxide dismutase-1 (SOD1) mutants, including those with unaltered enzymatic activity, are known to cause amyotrophic lateral sclerosis (ALS). Several destabilizing factors contribute to pathogenicity including a reduced ability to complete the normal maturation process which comprises folding, metal cofactor acquisition, intra-subunit disulphide bond formation and dimerization. Immature SOD1 forms toxic oligomers and characteristic large insoluble aggregates within motor system cells. Here we report that the cysteine-reactive molecule ebselen efficiently confers the SOD1 intra-subunit disulphide and directs correct SOD1 folding, depopulating the globally unfolded precursor associated with aggregation and toxicity. Assisted formation of the unusual SOD1 cytosolic disulphide bond could have potential therapeutic applications. In less reducing environments, ebselen forms a selenylsulphide with Cys111 and restores the monomer-dimer equilibrium of A4V SOD1 to wild-type. Ebselen is therefore a potent bifunctional pharmacological chaperone for SOD1 that combines properties of the SOD1 chaperone hCCS and the recently licenced antioxidant drug, edaravone.
Crystal structure of p-chloro-N-benzylhexahomotriazacalix[3]arene and of the complex of its zwitterionic form with neodymium(III) nitrate (2000)

p-Chloro-N-benzylhexahomotriazacalix[3]arene reacts with neodymium(III) nitrate to form a 1∶1 complex in which the cation is bound to the three phenoxide oxygen atoms and to three bidentate nitrate ions. In the uncomplexed ligand, the three phenolic oxygen atoms form hydrogen bonds with the nitrogen atoms, whereas, in the complexed form, the three amine groups are transformed into ammonium cations by intramolecular transfer of protons (zwitterionic form) and form hydrogen bonds with the complexed phenoxide groups. The formation of this complex is peculiar among other lanthanide complexes of calixarenes since it occurs without addition of a basic agent, other than the amine groups included in the ligand molecule itself.
Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters (2015)

Neurotransmitter:sodium symporters (NSSs) terminate neurotransmission by Na(+)-dependent reuptake of released neurotransmitters. Previous studies suggested that Na(+)-binding reconfigures dynamically coupled structural elements in an allosteric interaction network (AIN) responsible for function-related conformational changes, but the intramolecular pathway of this mechanism has remained uncharted. We describe a new approach for the modeling and analysis of intramolecular dynamics in the bacterial NSS homolog LeuT. From microsecond-scale molecular dynamics simulations and cognate experimental verifications in both LeuT and human dopamine transporter (hDAT), we apply the novel method to identify the composition and the dynamic properties of their conserved AIN. In LeuT, two different perturbations disrupting Na(+) binding and transport (i.e. replacing Na(+) with Li(+) or the Y268A mutation at the intracellular gate) affect the AIN in strikingly similar ways. In contrast, other mutations that affect the intracellular gate (i.e. R5A and D369A) do not significantly impair Na(+) cooperativity and transport. Our analysis shows these perturbations to have much lesser effects on the AIN, underscoring the sensitivity of this novel method to the mechanistic nature of the perturbation. Notably, this set of observations holds as well for hDAT, where the aligned Y335A, R60A, and D436A mutations also produce different impacts on Na(+) dependence. Thus, the detailed AIN generated from our method is shown to connect Na(+) binding with global conformational changes that are critical for the transport mechanism. That the AIN between the Na(+) binding sites and the intracellular gate in bacterial LeuT resembles that in eukaryotic hDAT highlights the conservation of allosteric pathways underlying NSS function.
Real-time target classification and tracking by using outdoor PTZ cameras at the edge (2022)

Tracking with a Pan-Tilt-Zoom (PTZ) camera has been a research topic in computer vision for many years. Compared to tracking with a still fixed camera, the images captured with a PTZ camera are highly dynamic because the vision becomes difficult under some realistic conditions such as fast camera movements, occlusion and similar objects to the tracked target. Also, compensating for these problems is even more complex on edge system. With the increasing availability of small single-board computers with high parallel processing power capabilities, tracking objects using an onboard computer in real time has become feasible. Although these onboard computers allow a wide variety of computer vision methods to be executed, there is still a need to optimize these methods for running time and power consumption. This paper proposes a hybrid application with low CPU consumption for surveillance objects to detect and track at the edge. To detect the target at the beginning and in the case where the track has been lost, we use the deep learning based YOLOv3 model. This model provides one of the best trade-offs between speed and accuracy in the literature. A kernelized correlation filter is used to track the detected object in real-time. Combining these two algorithms provides high accuracy and speed even on onboard computers. Under a real-time streaming condition, the proposed method yields better results than the original KCF in tracking accuracy and outperforms a deep learning-based tracker when a target has a vast movement.
Full-Electrochemical Preparation of Conducting/Insulating Binary Polymer Films (2001)

Binary polymer films consisting of an insulating polymer and a conducting polymer have been successfully prepared by sequential electropolymerization of the parent monomers. The insulating polymer (polyacrylonitrile or polyethylacrylate) is formed under cathodic polarization in a potential range where the growing chains are chemically grafted onto the nickel or carbon electrode. The conducting polymer (polybithiophene or polypyrrole) is formed by electrooxidation of the parent monomer. The electrochemical reactions and the electrochemical properties of the films have been analyzed by cyclic voltammetry and chronoamperometry. The influence of the main experimental parameters on the composition and morphology of the films has been investigated by X-ray photoelectron spectroscopy and atomic force microscopy. This approach strongly improves the adhesion of the conducting polymer as a result of its combination with the grafted polyacrylonitrile. This combination of insulating and conducting polymers is a way to tune the electroactivity of the conjugated chains.
Effect of Nb on Transformation Kinetics and Mechanical Properties in Zr-Al-Ni-Cu Metallic Glasses (2010)

The effect of Nb addition on the nucleation and grain growth behaviors has been investigated in the monolithic Zr65Al7.5Ni10Cu12.5Nb5 metallic glass. Nb has been well-known as an element for icosahedral quasicrystalline (QC) phase formation in the primary crystallization stage as well as for improving mechanical properties and corrosion resistance. The grain growth rate of the QC phase at near the crystallization temperature is 1.2×10−9 m/s, which is approximately 10 times smaller than that of the primary fcc Zr2Ni phase in the Zr65Al7.5Ni10Cu17.5 metallic glass. In contrast, nucleation rate increases drastically by Nb addition. It can be calculated as 1.2×1021/m3 s, which is approximately 105 times larger than that of the Zr65Al7.5Ni10Cu17.5 alloy. The results indicate that Nb is a very effective element for controlling grain growth and nucleation rates. Good plasticity is exhibited in the as-cast alloy, however, it is lost drastically even after the structural relaxation as well as the QC precipitation. Such significant change may be attributed to the local ordering and/or phase separating tendencies by a positive chemical affinity of the Zr-Nb pair.
Synthesis, Leishmanicidal Activity, Structural Descriptors and Structure–Activity Relationship of Quinoline Derivatives (2018)

Principal component analyses and hierarchical cluster analyses suggested volume and polar surface area as possible structural descriptors for the leishmanicidal activity. Furthermore, a comparison between molecular electrostatic potentials and leishmanicidal activities afforded a reasonable structure-activity relationship.
An experimental study to determine task size for rollback recovery systems (1988)

The effects of using a recovery cache to save the variables of a program are studied. A novel optimization model for rollback is formulated to include the effects of a recovery cache in rollback systems. The parameters of the model proposed are the maximum recovery time, the cache size, and the save and load time associated with the task size. The results are also discussed of an experimental study conducted to estimate the parameters of the programs that are critical for arriving at a suitable task size or cache size to minimize the cost of recovery.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
173. ABSOLUTE FLOW ESTIMATIONS USING DUPLEX PULSED SONOGRAPHY (1984)

McGahan, John P. M.D.; Lantz, Bo M.T. M.D.; Walter, John P. Ph.D., M.D. Author Information
Ortho metalations of ring-substituted benzyldimethylamines by butyllithium and condensations with benzophenone. Nucleophilic mechanism Cyclizations to phthalans (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrtho metalations of ring-substituted benzyldimethylamines by butyllithium and condensations with benzophenone. Nucleophilic mechanism Cyclizations to phthalansKarl Phillip Klein and Charles R. HauserCite this: J. Org. Chem. 1967, 32, 5, 1479–1483Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 May 1967https://pubs.acs.org/doi/10.1021/jo01280a038https://doi.org/10.1021/jo01280a038research-articleACS PublicationsRequest reuse permissionsArticle Views452Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts