gebhart/patrepeval huggingface dataset:
Geometric and optical isomers of cobalt(III) complexes containing two moles of the cyclic tridentate ligand derived from o-aminobenzaldehyde (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeometric and optical isomers of cobalt(III) complexes containing two moles of the cyclic tridentate ligand derived from o-aminobenzaldehydeSue C. Cummings and Daryle H. BuschCite this: J. Am. Chem. Soc. 1970, 92, 7, 1924–1929Publication Date (Print):April 1, 1970Publication History Published online1 May 2002Published inissue 1 April 1970https://pubs.acs.org/doi/10.1021/ja00710a023https://doi.org/10.1021/ja00710a023research-articleACS PublicationsRequest reuse permissionsArticle Views386Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Draft Genome Sequence of the Putative Marine Pathogen Thalassobius sp. I31.1 (2019)

<i>Thalassobius</i> sp. I31.1 is a putative pathogen involved in epizootic shell disease in the American lobster (Homarus americanus). We report here the draft genome sequence for <i>Thalassobius</i> sp. I31.1 and provide insight into its metabolism and links to environmental pollutant degradation.
The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial (2021)

End-stage renal disease (ESRD) patients on chronic hemodialysis have repeated blood exposure to artificial surfaces that can trigger clot formation within the hemodialysis circuit. Dialyzer clotting can lead to anemia despite erythropoietin and iron supplementation. Unfractionated heparin prevents clotting during hemodialysis, but it is not tolerated by all patients. Although heparin-free dialysis is performed, intradialytic blood entrapment can be problematic. To address this issue, we performed a randomized, double-blind, phase 2 study comparing AB023, a unique antibody that binds factor XI (FXI) and blocks its activation by activated FXII, but not by thrombin, to placebo in 24 patients with ESRD undergoing heparin-free hemodialysis. Patients were randomized to receive a single predialysis dose of AB023 (0.25 or 0.5 mg/kg) or placebo in a 2:1 ratio, and safety and preliminary efficacy were compared with placebo and observations made prior to dosing within each treatment arm. AB023 administration was not associated with impaired hemostasis or other drug-related adverse events. Occlusive events requiring hemodialysis circuit exchange were less frequent and levels of thrombin-antithrombin complexes and C-reactive protein were lower after AB023 administration compared with data collected prior to dosing. AB023 also reduced potassium and iron entrapment in the dialyzers, consistent with less blood accumulation within the dialyzers. We conclude that despite the small sample size, inhibition of contact activation-induced coagulation with AB023 was well tolerated and reduced clotting within the dialyzer. This trial was registered at www.clinicaltrials.gov as #NCT03612856.
Thermostat Interface and Usability: A Survey (2010)

This report investigates the history of thermostats to better understand the context and legacy regarding the development of this important tool, as well as thermostats' relationships to heating, cooling, and other environmental controls. We analyze the architecture, interfaces, and modes of interaction used by different types of thermostats. For over sixty years, home thermostats have translated occupants' temperature preferences into heating and cooling system operations. In this position of an intermediary, the millions of residential thermostats control almost half of household energy use, which corresponds to about 10percent of the nation's total energy use. Thermostats are currently undergoing rapid development in response to emerging technologies, new consumer and utility demands, and declining manufacturing costs. Energy-efficient homes require more careful balancing of comfort, energy consumption, and health. At the same time, new capabilities will be added to thermostats, including scheduling, control of humidity and ventilation, responsiveness to dynamic electricity prices, and the ability to join communication networks inside homes. Recent studies have found that as many as 50percent of residential programmable thermostats are in permanent"hold" status. Other evaluations found that homes with programmable thermostats consumed more energy than those relying on manual thermostats. Occupants find thermostats cryptic and baffling to operate because manufacturers often rely on obscure, and sometimes even contradictory, terms, symbols, procedures, and icons. It appears that many people are unable to fully exploit even the basic features in today's programmable thermostats, such as setting heating and cooling schedules. It is important that people can easily, reliably, and confidently operate thermostats in their homes so as to remain comfortable while minimizing energy use.
Robust State Estimation and Integrity Monitoring within Multi-Sensor Navigation System. (2021)

In autonomous applications for mobility and transport, a high-rate and highly accurate vehicle states estimation is achieved by fusing measurements of global navigation satellite systems and inertial sensors. Since this kind of state estimation suffers from poor parameterization, environment disturbances, or even software and hardware failures, this paper introduces a novel scheme of multi-sensor navigation system involving extended H$_\infty$ filter for robustness enhancement of the navigation solution and zonotope for protection level generation in combination with vehicle dynamic-model-aided fault detection of the inertial sensor for reliable integrity monitoring. The innovative scheme, applying extended H$_\infty$ filter and zonotope, is shown as part of a tightly-coupled navigation system. Further, the consideration of redundant information, e.g., vehicle dynamic model, for fault detection purpose has long been investigated and is systematically described and discussed using interval analysis theory in current publication. The robustness of the designed approach is validated with real-world data in post-processing: decimeter positioning accuracy is maintained, while the solution of conventional extended Kalman filter diverges from ground truth; the difference is also significant under inertial sensor faults. A real-time implementation of the designed approach is promising and aimed in the future work.
Deviation-based and similarity-based contextual SLIM recommendation algorithms (2014)

Context-aware recommender systems (CARS) have been demonstrated to be able to enhance recommendations by adapting users' preferences to different contextual situations. In recent years, several CARS algorithms have been developed to incorporated into the recommender systems. For example, differential context modeling (DCM) was modified based on traditional neighborhood collaborative filtering (NBCF), context-aware matrix factorization (CAMF) coupled contextual dependency with the matrix factorization technique (MF), and tensor factorization directly models contexts as additional dimensions in the multi-dimensional space, etc. CAMF works well but it is difficult to interpret the latent features in the algorithm. DCM is good for explanation but it may only work well on data sets with dense contextual ratings. Recently, we successfully incorporate contexts into Sparse LInear Method (SLIM) and develop contextual SLIM (CSLIM) recommendation algorithms which take advantages of both NBCF and MF. CSLIM are demonstrated as more effective and promising context-aware recommenders. In this work, we provide the introduction on the framework of the CSLIM algorithms, present the current state of the research, and discuss our ongoing future work to develop and improve our CSLIM models for context-aware recommendations.
Group IV–cobalt complexes as catalysts for silylation and cyclic ether polymerization (1970)

Dicobalt octacarbonyl was found to catalyse the reaction: R32SiH + XH [graphic omitted] XSiR32+ H2(1) where X = R1O, R1CO2, R1CONH + R31SiO but not when X = ArO (R = alkyl, Ar = aryl), while tetrahydrofuran was polymerized to poly-(1,4-butylene oxide)(ca. 50,000 molecular weight) in the presence of dicobalt octacarbonyl and a silane.
Supermode Dispersion and Mode Transitions in Silicon-on-Insulator Waveguide Arrays (2010)

We have measured and modeled the spectral group index of the supermodes of a two channel silicon photonic wire array. We observe the transition from two coupled waveguides to a single guided slot mode.
MAPbBr3 perovskite solar cells via a two-step deposition process (2019)

Organometal halide perovskite solar cells are becoming one of the most competitive emerging technologies. They have reached a power conversion efficiency (PCE) of 22.7% in 10 years. Their high efficiency and simple fabrication process render perovskite solar cells a promising player in the field of third-generation photovoltaics. The deposition methods play an important role in the fabrication of a high quality films. In this paper, we report the preparation of methylammonium lead bromide (MAPbBr<sub>3</sub>) thin film using a two-step method based on the transformation of PbBr<sub>2</sub> into MAPbBr<sub>3</sub> perovskite after dipping in a MABr solution. The effects of the dipping time and the annealing time on the photovoltaic, optical and structural properties of the devices were studied. The dipping time treatments of the inorganic film in organic solution were conducted from 30 s to 15 min. The obtained result showed that the PCE of the devices was improved with the increase of dipping time. In addition, an increase of annealing time induces an enhancement of the perovskite properties. Furthermore, the as-fabricated perovskite solar cell dipped and annealed for 10 min exhibited the highest power conversion efficiency of 4.8% with a short circuit current density of 16.16 mA cm<sup>-2</sup>, an open circuit voltage of 0.84 V, and a fill factor of 35.50.
Visualization of the intrarenal distribution of capillary blood flow (2019)

This study describes a modified technique to fill the renal vasculature with a silicon rubber (Microfil) compound and obtain morphologic information about the intrarenal distribution of capillary blood flow under a variety of conditions. Kidneys and cremaster muscles of rats were perfused in vivo with Microfil using a perfusion pressure equal to the animal's mean arterial pressure at body temperature. Microfil did not alter arteriolar diameter or the pattern of flow in the microcirculation of the cremaster muscle. The modified protocol reproducibly filled the renal vasculature, including; glomerular, peritubular, and vasa recta capillaries. We compared the filling of the renal circulation in control rats with that seen in animals subjected to maneuvers reported to alter the intrarenal distribution of blood flow. Infusion of angiotensin II, hypotension, volume expansion, and mannitol- or furosemide-induced diuresis redistributed flow between renal cortical and medullary capillaries. The advantage of the current technique is that it provides anatomical information regarding the number, diameter, and branching patterns of capillaries in the postglomerular circulation critical in determining the intrarenal distribution of cortical and medullary blood flow.
P3‐047: OPTIMIZATION OF FORMYL PEPTIDE RECEPTOR 2 (FPR2) AGONISTS WITH NEUROPROTECTIVE PROPERTIES IN MODELS OF NEUROINFLAMMATION RELATED TO ALZHEIMER'S DISEASE (2019)

recent evidences indicates that dysfunctions in metabolism or in the action of specialized pro-resolving mediators (SPMs) can contribute to the impairment in the resolution phase of the inflammatory response, which culminates in chronic neuroinflammation, a hallmark of Alzheimer's Disease (AD). Resolution of inflammation (RoI) is altered in the brain of AD patients and the administration of SPMs in animal models of AD can reduce the neuropathology and improve cognitive deficits.1 FPR2 is a GPCR that plays a pivotal role in RoI since the SPMs lipoxin A4 and resolvin D1 bind to this receptor. we recently identified a series of drug-like FPR2 agonists with neuroprotective properties in in vitro models of neuroinflammation related to AD. Our FPR2 agonists exert in vitro neuroprotective effects in a dose range (0.5-10 μM), which implies high in vivo dosage requirements and potential unwanted off-target side effects.2 Thus, we designed a set of compounds based on previous structure-activity relationships in order to improve FPR2 agonist potency without affecting drug-like properties. The newly synthesized compounds were tested for their FPR2 agonist activity and stability to oxidative metabolism. The anti-inflammatory and pro-resolving effects of the most promising agonists were evaluated in microglial cell lines stimulated with LPS or IFN-g. The effects on cell viability (MTT assay), cell metabolic activity (LDH activity), and production of inflammatory cytokines were also assessed. the performed structural modifications improved FPR2 agonist potency as several compounds exhibited EC50 values in the nanomolar range (26-100 nM). Moreover, in vitro stability to oxidative metabolism was further increased leading to compounds with better bioavailability. Finally, selected compounds exerted anti-inflammatory effects in the nanomolar dose range, comparable to that of LXA4, in various in vitro models of neuroinflammation.
Inhibitory Actions of Keoxifene on Luteinizing Hormone Secretion in Pituitary Gonadotrophs* (1988)

The effect of keoxifene (LY 156 758) on GnRH-stimulated LH release and its ability to antagonize estrogen actions were investigated in rat anterior pituitary cells. Estrogens exert either stimulatory or inhibitory effects on GnRH-induced LH secretion in rat pituitary cells depending on the incubation time with the steroid. When pituitary cells were treated for 24 h with 10(-9) M estradiol, the LH response to GnRH was clearly enhanced, and this effect was completely inhibited by 300 nM keoxifene. Short term treatment (4 h) of pituitary cells with 10(-9) M estradiol inhibits GnRH-stimulated LH release, and this effect was also blocked by keoxifene in a dose-dependent manner. In the absence of exogenous estrogen the treatment of pituitary cells for 4 h with increasing concentrations of keoxifene reduced the LH response to 10(-9) M GnRH only at very high concentrations (10(-5) M) of the antiestrogen. After treatment for 24 h, the inhibitory effect of keoxifene was evident at concentrations greater than or equal to 10(-8) M, with a reduction of GnRH-induced LH release by up to 60%. The effects of the antiestrogen were also analyzed in a dynamic culture system, in which pituitary cells grown on microcarrier beads were continuously perifused with medium and stimulated with GnRH in a pulsatile fashion. The LH response to a 2 min pulse of 10(-9) M GnRH was reduced in magnitude after 40 min of perifusion with 10(-9) M estradiol. When keoxifene (300 nM) was present at the same time, the LH response was identical to that observed in vehicle-treated cells. At the concentration of 300 nM, keoxifene per se did not change the responsiveness of the pituitary cells to the GnRH stimulus. These findings show that keoxifene is a potent antagonist of both positive and negative estrogen actions in the pituitary gonadotroph. In addition, after short term treatment with high concentrations or after long term treatment, keoxifene itself exerts an inhibitory effect on GnRH-induced LH secretion.
Isolation and Structural Studies of Human Milk Oligosaccharides That Are Reactive with a Monoclonal Antibody MSW 1131 (1991)

We have determined the structures of six oligosaccharides isolated from human milk using a monoclonal antibody, MSW 113. The isolation involved affinity chromatography on a column of the immobilized monoclonal antibody and high-performance liquid chromatography. From the results of 500 and 600 mHz 1H NMR spectroscopy and fast atom bombardment-mass spectrometry their structures were deduced to be: [formula; see text] Two of these oligosaccharides, numbers 4 and 5, have not previously been described. All of them bound to MSW 113, but their reactivities are weaker than those of sialyl-Le(a) oligosaccharides. The results indicate that MSW 113 reacts with oligosaccharides with the mono- and disialyl-Le(a), and other sialyl type 1 structures.
Using Multi-agent and Case-Based Reasoning for Collaboration in a Supply Chain (2004)

The importance of collaboration in a supply chain has led several scholars to suggest diverse approaches. Questions still remain concerning the best way of dealing with collaboration and conflicts under demand and supply uncertainties. This research proposes a model based on case-based reasoning and multi-agents for supply chain collaboration and information sharing (MACBR-SCM). The MACBR-SCM is implemented as a web service to facilitate communications among multiagents. The MACBR-SCM is validated for various collaboration mechanisms. The results of the statistical tests reveal the importance of enhanced collaboration for the best performance.
Sparse inversion SVD method for dispersion extraction of ultrasonic guided waves in cortical bone (2015)

In the study, we propose a sparse inverse singular value decomposition (SI-SVD) technique, which combines SVD and a least-squares sparse inversion method to improve the resolution of the ultrasonic (US) guided waves (GW) spectrum of long cortical bones. The method was assessed using synthetic data and experimental signals recorded on a 4-mm thick bone-mimicking plate. The results illustrated that the SI-SVD technique can achieve a more accurate determination of the dispersion relationships with enhanced noise filtering, which should be helpful to the USGW-based assessment of long cortical bone.
Synthesis and Swelling Kinetics of Poly(Dimethylaminoethyl acrylate methyl chloride quaternary-co-itaconic acid) Hydrogels (1999)

Hydrogels of dimethylaminoethyl acrylate methyl chloride quaternary and itaconic acid have been synthesized with different monomer ratios. The swelling process of the different xerogels immersed in water was monitored by the weight increase as a function of time. The swelling isotherms consisted of a steep initial portion and leveled off asymptotically to the equilibrium swelling limit. The experimental data suggest clearly that the swelling process obeys second-order kinetics. The rate constant and the equilibrium water content were determined for every monomer ratio from the experimental straight lines obtained according to the kinetics equation. Both magnitudes decreased as the itaconic acid content in the xerogel increased.
Association Between Serum Relaxin and Subsequent Shoulder Instability (2016)

Ligamentous laxity correlates with shoulder instability. Relaxin is a hormone that has been linked to laxity in the knee and has been shown to be a risk factor for anterior cruciate ligament (ACL) injury. This study prospectively evaluated the association between relaxin and acute shoulder instability. A prospective cohort study of 1050 young athletes was performed between 2006 and 2010. The authors conducted a nested case-control analysis within this cohort to evaluate the association between preinjury serum relaxin concentration and the likelihood of subsequent shoulder instability. The study compared 53 patients who had shoulder instability and 53 control subjects who were matched for sex, age, height, and weight. The serum relaxin concentration in preinjury baseline samples was tested with enzyme-linked immunosorbent assay analysis in duplicate. Independent t tests were performed to identify differences in mean serum relaxin concentration between patients with shoulder instability and uninjured control subjects. Logistic regression was used to evaluate whether preinjury baseline serum relaxin concentration was associated with the subsequent likelihood of shoulder instability. Of the 53 patients with instability, 13 (25%) had a detectable serum relaxin concentration compared with 9 (17%) of uninjured control subjects (P=.34). Mean serum relaxin concentration in the injury group was 3.69±1.78 pg/mL and 2.20±0.97 pg/mL in uninjured control subjects (P=.02). Increased serum relaxin concentration was associated with the subsequent likelihood of acute shoulder instability. Subjects were 2.18 times (odds ratio, 2.18; 95% confidence interval, 1.01-4.76) more likely to have acute shoulder instability during the follow-up period for every 1-pg/mL increase in serum relaxin concentration at baseline. The findings suggest that serum relaxin concentration is associated with a risk of subsequent shoulder instability in young athletes. Further research on the role of relaxin in shoulder instability is warranted. [Orthopedics. 2016; 39(4):e724-e728.].
Hybridoma-derived human suppressor factors: Inhibition of growth of tumor cell lines and effect on cytotoxic cells (1991)

With the objective of developing human T-T cell hybrids producing B-cell growth factor, we fused concanavalin A-activated T lymphocytes with cells of the Jurkat T cell line. The hybrids were selected on the basis of their ability to form colonies in soft agar, whereas the parent Jurkat T cell line did not. T-T cell hybrids were HLA-typed, screened by functional tests, and recloned by limiting dilution. In addition to obtaining B-cell growth factor-producing hybrids, we also obtained certain other T-T cell hybrids (as determined by HLA-typing) producing suppressor factors inhibiting proliferative responses and antibody production by human lymphocytes. Subsequently, a suppressor factor with similar inhibitory properties was identified in supernatants of the Jurkat T cell line. However, the Jurkat factor exhibited different biochemical and functional properties than the hybridoma-derived suppressor factors. Using two-parameter cell cycle analysis and the metachromatic fluorochrome acridine orange, we found that the hybridoma-derived 160 and 169 suppressor factors arrested phytohemagglutinin-induced proliferative of peripheral blood mononuclear cells in the G0/G1 phase of the cell cycle, whereas the Jurkat suppressor factor arrested proliferation in the S phase. Incubation of peripheral blood mononuclear cells with the 160, 169, or Jurkat suppressor factors for 24 hr at 37 degrees C, followed by washing, did not alter their cell cycle progression (or RNA content) in response to stimulation with phytohemagglutinin. The hybridoma-derived 160 and 169 suppressor factors and the Jurkat factor inhibited the growth but not the viability of cells from the following human tumor cell lines: A673 sarcoma cell line, SK-LC-6 and SK-LC-14 lung cell lines, SB, Raji, and Daudi lymphoblastoid cell lines, and FARR malignant melanoma cell line. In contrast, it did not affect the growth of murine L1210 cells and FS-4 normal human diploid fibroblasts. The hybridoma-derived 160 suppressor factor was selected to investigate its effect on cell-mediated cytotoxicity. The 160 suppressor factor did not inhibit natural killer cytotoxicity or its augmentation by interferon alpha or interleukin 2 or the generation of lymphokine-activated killer cells. However, this factor partially inhibited the generation of specific T cell-mediated cytotoxicity.