gebhart/patrepeval huggingface dataset:
Murine embryonic stem cell fusion-mediated reprogramming of primary mouse embryonic fibroblasts (2008)

We fused J1 129/SvJae puromycin resistant embryonic stem cells (ESCs) with BALB/c ROSA26βgeo primary mouse embryonic fibroblasts (MEFs) in effort to reprogram the somatic-sourced genome present within hybrids. We purposefully used cells that differed in genetic backgrounds to allow for the detection of the chromosomal source of expression in hybrid cells as no other fusion studies had utilized this strategy which would allow us to develop a tractable system of studying reprogramming events initiated by fusion. Polyethylene glycol 1500 was used to combine the membranes of the two cell types and resulted in the establishment of hybrid lines A3, A4, and A7. Hybrids resembled stem cells in morphology and growth characteristics. Hybrid cell lines were characterized by detecting the presence of somatic-sourced ROSA26βgeo in hybrids and by assaying the chromosomal compliments present within hybrid cells. Gene expression profiles of hybrid cell lines were evaluated by reverse-transcriptase PCR and Affymetrix DNA microarrays which resulted in similar but not identical expression patterns of hybrids as compared to ESCs. Hybrid cells shared many properties of ESCs including pluripotentcy as hybrid cells formed embryoid bodies and expressed markers of all three primordeal germ layers. Evidence of somatic reprogramming was collected by RNA fluorescence in situ hybridization which detected four sites of transcription of the stem cell pluripotency factor Oct4 in hybrid cells. Sequencing of expressed single nucleotide polymorphisms between 129 and BALB/c detected bi-allelic expression of chromatin remodeling genes in hybrid cells and together these results indicate that reprogramming of the somatic genome does indeed take place when fused with ESCs.^
DNA-inspired characterization and detection of novel social Twitter spambots (2019)

Spambot detection is a must for the protection of cyberspace, in terms of both threats to sensitive information of users and trolls that may want to cheat and influence the public opinion. Unfortunately, new waves of malicious accounts are characterized by advanced features, making their detection extremely challenging. In contrast with the supervised spambot detectors largely used in recent years and inspired by biological DNA, we propose an alternative, unsupervised detection approach. Its novelty is based on the idea of modeling online user behaviors with strings of characters representing the sequence of the user&apos;s online actions. Exploiting this nature-inspired behavioral model, the proposed technique lets groups of spambots emerge from the crowd, by comparing the accounts&apos; behaviors. Results show that the proposal outperforms the best-of-breed algorithms commonly employed for spambot detection.
<title>Mode-locked repetition-rate feedback stabilization of semiconductor diode lasers</title> (1993)

Feedback stabilization of the pulse repetition rate is demonstrated for an external cavity mode- locked semiconductor diode laser. The design procedure for repetition rate feedback stabilization is described. We propose feedback stabilization as a method of pulse stabilization for high repetition rate monolithic devices. These monolithic devices are expected to play an important role in applications such as optical clock generation and millimeter-wave clock distribution, but previously no timing stabilization technique had been developed which could be used up to the maximum repetition rates.
Quality of life of prostate cancer (PCa) patients with testosterone deficiency symptoms (TDS) before initiation of gonadotropin-releasing hormone (GnRH) agonist therapy: Subgroup analysis of EQUINOXE study. (2020)

232 Background: Both PCa and TDS risk increase with age. Patients may therefore suffer from both conditions, and their quality of life (QoL) be reduced. Unexpectedly, multivariate analysis of the EQUINOXE study (NCT02630641) identified baseline TDS as a significant factor improving QoL after 6 months of GnRH agonist therapy. We therefore aim to analyze baseline parameters of this subgroup. Methods: EQUINOXE was a French prospective, multicenter, non-interventional study. Urologists recruited partner-patient couples with PCa for whom androgen deprivation therapy (ADT) was indicated. Data were collected at inclusion and after 6 months of treatment, on QoL (WHOQOL-BREF), perception of disease (B-IPQ), symptoms of the disease (QLQ-PR25) and perception of cohesion within the patient-partner relationship (dyadic adjustment, DAS-16). TDSat baseline, determined by QLQ-PR25 “treatment related symptoms” score ≥25/100, was the main parameter identified by multivariate analysis in improvement of QoL (OR [95% CI]: 3.0 [1.46, 6.17]. Post hoc subgroup analysis was made to compare baseline parameters of patients with and without TDS. Results: 487 patients were included in this analysis, 26% of whom had TDS at baseline. Symptoms were (quite a bit or very much): feeling of less masculinity (55.2%), hot flushes (41%), weight gain (40.1%) and enlarged nipples (23.1%). Patients with TDS were slightly older than those without TDS (75.3±8.3vs 73.8±8y.o), had significantly worse performance Status (0-1-2+ in 37.0-45.7-17.3% vs 52.8-36.4-10.8%, p=0.0153) and suffered more frequently from recurrent PCa (35.7% vs 24.7%, p=0.0175). Symptoms other than urinary and sexual (but including asthenia) were more frequent (p=0.0126). All dimensions of WHOQOL-BREF were rated significantly worse. Total score of illness (B-IPQ) was worse: 42.2±8.2 vs39.1±9.4, p=0.0040. Cohesion in the couple (DAS score) was worse: 98.6±22.3 vs107.3±20.9, p=0.0006. Conclusions: Patients with TDS experienced at baseline a worse cohesion of the couple and a lower QoL than patients without TDS but benefited relatively more from ADT in term of QoL. Clinical trial information: NCT02630641.
Derivation of Lanthanide Series Crystal Field Parameters From First Principles (2019)

Two series of lanthanide complexes have been chosen to analyze trends in the magnetic properties and crystal field parameters (CFPs) along the two series: The highly symmetric LnZn<sub>16</sub> (picHA)<sub>16</sub> series (Ln=Tb, Dy, Ho, Er, Yb; picHA=picolinohydroxamic acid) and the [Ln(dpa)<sub>3</sub> ](C<sub>3</sub> H<sub>5</sub> N<sub>2</sub> )<sub>3</sub> ⋅3H<sub>2</sub> O series (Ln=Ce-Yb; dpa=2,6-dipicolinic acid) with approximate three-fold symmetry. The first series presents a compressed coordination sphere of eight oxygen atoms whereas in the second series, the coordination sphere consists of an elongated coordination sphere formed of six oxygen atoms. The CFPs have been deduced from ab initio calculations using two methods: The AILFT (ab initio ligand field theory) method, in which the parameters are determined at the orbital level, and the ITO (irreducible tensor operator) decomposition, in which the problems are treated at the many-electron level. It has been found that the CFPs are transferable from one derivative to another, within a given series, as a first approximation. The sign of the second-order parameter <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msubsup><mml:mi>B</mml:mi> <mml:mrow><mml:mn>0</mml:mn></mml:mrow> <mml:mn>2</mml:mn></mml:msubsup> </mml:math> differs in the two series, reflecting the different environments. It has been found that the use of the strength parameter S allows for an easy comparison between complexes. Furthermore, in both series, the parameters have been found to decrease in magnitude along the series, and this decrease is attributed to covalent effects.
Distributed Public Key Infrastructure and PSK Exchange Based on Blockchain Technology (2018)

Public key distribution and device authentication remain the main security challenges in many systems and applications. Existing solutions are based on Public Key Infrastructures (PKI) backed by Certificate Authorities (CA) to validate the authenticity of the devices. However, distributing and provisioning certificates for each client showed to be impractical especially for Internet of Things (IoT) devices. In this paper we propose a distributed PKI (Public Key Infrastructure) platform based on the Ethereum Blockchain. It contains a decentralized key-store that holds the public keys of all devices, and includes a generic protocol for PSK (Pre-Shared Keys) distribution. PSK keys can then be used by PSK-based security protocols (TLS-PSK, DTLS-PSK, SRTP...) for securing the communication channel between two devices. This platform includes a client-side module, a public key management module configured on the server, and a smart contract software deployed on the Ethereum Blockchain network. This generic platform can be used by many applications for client and server authentication, data integrity, and secure peer to peer communications. Moreover, this promising system may potentially eliminate the trust requirement imposed by the existing PKI/CAs infrastructure on clients.
Weight-aware robot motion planning for lift-to-pass action (2014)

Passing an object between two humans is a very natural and seamless operation, mainly thanks to non-verbal cues which facilitate the process. Just from action observation, humans can easily anticipate where and when a passing movement will end and how heavy the transported object is. But how could this natural understanding be ported to non-human agents? We introduce a simple robotic architecture to enable the iCub humanoid robot to visually recognize the weight of an object and select a lift-to-pass motion which implicitly communicates such information to the action partner. In this work we mainly focus on the building and training of the procedural memory module needed to store the association between the mass of an object and its visual appearance, and we propose how such a model can be used to successively select communicative lifting motions.
Restriction capillaries as an innovative mixing principle for intermediate solvent exchange in multidimensional analysis (2017)

status: Published
Quality of Life in a 2-Year Follow-up: Signs of PNP Predicting Cognitive Functioning in Survivors Treated in the HD10–12 Trials of the German Hodgkin Study Group (GHSG). (2008)

Abstract Purpose: Hodgkin Lymphoma (HL) is one of the best curable cancers in adults. Thus, current research is focusing on the increasing proportion of HL survivors with respect to the long-term consequences of therapy. Especially health related quality of life (QoL) needs thorough investigation since this is relevant for HL patients, complex and so far there is limited knowledge. QoL incorporates different aspects such as general QoL, fatigue, emotional, physical, role, social, sexual and cognitive functions. This analysis is focusing on QoL in the HD10–12 trials of the GHSG with special emphasis on cognitive functions (CF) and possible predictors in a 2 year follow-up. Methods: Patients of the GHSG trials HD10–12 completed the QLQ-C30, the MFI20 and some additional items at the time of diagnosis, after chemotherapy, after radiotherapy and at follow-up examinations. We describe the courses of the QLQ-C30 scales with means and 95%-confidence intervals for each measurement point and in relation to the respective norm values. In accordance with well established criteria, we used a cut off point of 10 points below the expected value to define self reported cognitive deficits (CD). In multiple regressions we analysed the role of the following predictors for cognitive functions 2 years after treatment: age, sex, disease stage, treatment modality, baseline score of cognitive functioning and symptoms of peripheral neuropathy (PNP) before and after chemotherapy application. Results: In the sample of 3608 patients all scales showed abnormal values from the beginning, further deterioration to the end of chemotherapy and continuous recovery from the end of radiotherapy on. Most scales improved clearly beyond their pre-treatment values but only physical functioning finally approached normal values. The CF scale showed a remarkable flat long term course and, opposed to the other scales, reached no improvement beyond the pre-treatment level. In 1044 patients with baseline and 2 year results, 439 met the criteria of relevant CD at baseline. Of these, 60.4% still felt handicapped after 2 years and 39.6% were in the range of normal values. 605 patients reported no CD at baseline and 69.6 % of them remained unaffected after 2 years (30.4% had developed CD). After adjustment for age, sex, disease stage, treatment modality and CF baseline scores, the regression analyses showed significant impact of symptoms of PNP before (p&amp;lt;.001) and after (p=.002) chemotherapy on CF after 2 years. Conclusion: In this large prospective study most QoL domains are remarkably improved after recovery from HL. In contrast CD occur frequently and show virtually no improvement. Symptoms of PNP as well as baseline values of CF are specifically predictive of future cognitive complaints. Further studies are necessary to investigate whether these results could be used for treatment modification or the development of intervention strategies.
Enolate Additions to a Chiral 3-Hydroxypropionate 2,3-Dication Equivalent. Enantioselective Synthesis of β,δ-Dihydroxy Esters (1997)

The use of optically active dicarbonyl cyclopentadienyliron(vinyl ether) BF(4) salts, 3 and 4, as enantioselective 3-hydroxypropionate 2,3-dication equivalents is outlined. Complexes 3 and 4 are readily available by exchange etherification of 2, and these have been transformed to enantiomeric dicarbonyl (eta-cyclopentadienyliron)(eta(2)-1-methoxypropene) BF(4) 5 and ent-5. Complex 5 has been converted to the corresponding p-methoxybenzyloxy vinyl ether complex 7 by exchange etherification. Condensation of this salt with a number of terminal and nonterminal enolates yields adducts, which are then transformed by redox-promoted alkoxycarbonylation, followed by alcohol deprotection, to optically active 2-methyl-3-hydroxy-5 keto esters. 1,3-Reduction of these ketols can be effected to give either syn- or anti-1,3-diols and thence their related pentanolides.
Observations on an introduced bud scale, Physokermes hemicryphus (Homoptera: Coccidae), infesting Norway spruce in Idaho (2004)

An introduced bud scale on Norway spruce (Picea abies (L.) Karst. (Pinaceae)) in Idaho, formerly thought to be Physokermes piceae Schrank (Homoptera: Coccidae), is identified as Physokermes hemicryphus (Dalman). Secondary lateral branches of infested Norway spruce become pendent as a result of growing abnormally in length relative to diameter. The scale reproduces by parthenogenesis in North America; no male is known there. Mature females in situ resemble a branch bud. An average of 2.2 females occurred per infested node. They grew larger in late May, at which time they protruded visibly from beneath branch bud scales of the previous year and became immersed in their secreted honeydew. At maturity, females contained a prolific number of eggs (290858). The eggs hatched into nymphs within the rigid exoskeleton of the dead female in late June. Nymphs emerged during July and migrated distally along a branch. They overwintered as second (final) instars attached to needles or beneath bud scales at the branch node from which the current-year terminal emanated. Four species of hymenopterous parasites were reared from adult scales. Of these, Americencyrtus sp. (Hymenoptera: Encyrtidae) was most abundant. It parasitized a majority of first instar nymphs but allowed them to develop to maturity the following spring before destroying their embryonic eggs and emerging in synchrony with appearance of nymphs of unparasitized females.
Multi-functionalization of helical block copoly(α-peptide)s by orthogonal chemistry (2011)

Diblock copoly(α-peptide)s bearing functional side-chains (i.e., azido or allyl) that are readily derivatized by “click” chemistry have been synthesized by primary amine-initiated sequential polymerization of the corresponding N-carboxyanhydrides (NCAs). Facile derivation of the side-chains has been demonstrated, in which mannose moieties are quantitatively attached via the alkyne–azide [2 + 3] Huisgen cycloaddition to form amphiphilic block copoly(α-peptide)s that retain their helical conformations in solution. Allyl side-chains residing in the hydrophobic core can be further functionalized with high efficiency by radical thiol–ene addition reactions despite the tendency of the amphiphilic precursors to aggregate.
Work in progress - teaching speech signal processing and coding using LabVIEWTM (2007)

This paper presents a visual programming and visualization tool for use in covering signal processing aspects of speech coding in a DSP class. The tool is based on the National Instruments LabVIEW™ environment. The framework of this tool was built using existing C code as a library along with LabVIEW’s native functionallties. Standardized linear predictive coding algorithms have been implemented; these are used to demonstrate in our DSP classes how digital filters and signal modeling is utilized in cellular and military communications. Experiments covered include the introduction of speech synthesis models, parameterization of speech in terms of filter and excitation parameters, and robustness of speech parameters to additive and channel noise. The tool provides capabilities for both quantitative and subjective assessment of the synthesized speech signal. An assessment process for the tool is in place and preliminary results will be presented at the conference.
Applying coordinate transformations to multi-DOF shaker control (2006)

The dynamic characteristics of test fixtures, test articles and multiple shakers or actuators for multi-degree-of-freedom (MDOF) dynamic testing may cause the number of desired degrees of freedom for MDOF operations to not match the number of exciters or control transducers being used. Thus, it is often necessary to transform the response from multiple control transducers and the capability of multiple exciters that are being used from actuator space to MDOF space and vice-versa to effectively perform such tests. These operations are now capable of being directly performed within the software used for MDOF control to increase test flexibility and greatly reduce test setup time. This article describes current applications of these techniques with multiple shakers and examines the control of torsional motion in large plates as a by-product of coordinate transformation.
Magneto-rheological variable inertia flywheel (2018)

A novel vibration absorber based on variable inertia flywheel by using magnetorheological fluid (MRVIF) was proposed in this study. The effect of rotational speed and the excitation current applied to MR damper on the moment of inertia are analytically developed. Under different rotation speeds and excitation currents, the moment of inertia is calculated. To verify the effectiveness of the proposed MRVIF, the prototype of MRVIF was manufactured. Experiments are performed to validate the effectiveness and the variable characteristics of the moment of inertia of the MRVIF under different excited conditions. The results show that the moment of inertia of the MRVIF can semi-actively be tuned. The test results are in good agreement with the simulation results.
Influence of ingesting a carbohydrate‐electrolyte solution on endurance capacity during intermittent, high‐intensity shuttle running (1995)

The aim of this study was to examine the effects of ingesting a carbohydrate-electrolyte solution on endurance capacity during a prolonged intermittent, high-intensity shuttle running test (PIHSRT). Nine trained male games players performed two exercise trials, 7 days apart. On each occasion, they completed 75 min exercise, comprising of five 15-min periods of intermittent running, consisting of sprinting, interspersed with periods of jogging and walking (Part A), followed by intermittent running to fatigue (Part B). The subjects were randomly allocated either a 6.9% carbohydrate-electrolyte solution (CHO) or a non-carbohydrate placebo (CON) immediately prior to exercise (5 ml kg-1 body mass) and every 15 min thereafter (2 ml kg-1 body mass). Venous blood samples were obtained at rest, during and after each PIHSRT for the determination of glucose, lactate, plasma free fatty acid, glycerol, ammonia, and serum insulin and electrolyte concentrations. During Part B, the subjects were able to continue running longer when fed CHO (CHO = 8.9 +/- 1.5 min vs CON = 6.7 +/- 1.0 min; P < 0.05) (mean +/- S.E.M.). These results show that drinking a carbohydrate-electrolyte solution improves endurance running capacity during prolonged intermittent exercise.
THE RECOGNITION METHOD OF RESERVOIR WITH GAS-CAP (2007)

There are a variety of development schemes that can be used to exploit reservoir with gas-cap,from the basic principles of reservoir with gas-cap development,through the analysis of oil and gas reservoir characteristics of the water distribution in lunan1 Well area in Xinjiang ShiXi Oilfield,and the study of further recognition about the reservoir with gascap,a identification method is summarized.Application eigenvalue method and the production of dynamic information law is proposed to identify the reservoir with gas-cap.A good result is obtained when application on LuNan 1 wells to identify the practical method.
DICTIONARY OF THE ECONOMIC PRODUCTS OF INDIA pages 401 to 479 (2014)

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Using mobile phones as acoustic sensors for high-throughput mosquito surveillance (2017)

The direct monitoring of mosquito populations in field settings is a crucial input for shaping appropriate and timely control measures for mosquito-borne diseases. Here, we demonstrate that commercially available mobile phones are a powerful tool for acoustically mapping mosquito species distributions worldwide. We show that even low-cost mobile phones with very basic functionality are capable of sensitively acquiring acoustic data on species-specific mosquito wingbeat sounds, while simultaneously recording the time and location of the human-mosquito encounter. We survey a wide range of medically important mosquito species, to quantitatively demonstrate how acoustic recordings supported by spatio-temporal metadata enable rapid, non-invasive species identification. As proof-of-concept, we carry out field demonstrations where minimally-trained users map local mosquitoes using their personal phones. Thus, we establish a new paradigm for mosquito surveillance that takes advantage of the existing global mobile network infrastructure, to enable continuous and large-scale data acquisition in resource-constrained areas.
Direct Bar Code Writing in Turning Operations (2013)

The paper presents a method to store data in a workpiece directly during its manufacturing process. During turning a sort of bar code can be added to a workpiece by simply modifying its surface. The code can be written by using the same tool used for rough-turning or finishing, can be fully automatized and the new microtexture can be easily read along all the cylindrical surface. The written code involves a limited length and does not alter deeply the functional characteristic of the surface, while the wide lateral surface prevents the information to be lost as a consequence of dents and scratches.