gebhart/patrepeval huggingface dataset:
Simultaneous three-dimensional velocity and mixing measurements by use of laser Doppler velocimetry and fluorescence probes in a water tunnel (1994)

A water tunnel investigation was conducted to demonstrate the capabilities of a laser-based instrument that can measure velocity and fluorescence intensity simultaneously. Fluorescence intensity of an excited fluorescent dye is directly related to concentration level and is used to indicate the extent of mixing in flow. This instrument is a three-dimensional laser Doppler velocimeter (LDV) in combination with a fluorometer for measuring fluorescence intensity variations. This capability allows simultaneous flow measurements of the three orthogonal velocity components and mixing within the same region. Two different flows which were generated by two models were studied: a generic nonaxisymmetric nozzle propulsion simulation model with an auxiliary internal water source that generated a jet flow and an axisymmetric forebody model with a circular sector strake that generated a vortex flow. The off-body flow fields around these models were investigated in the Langley 16- by 24-Inch Water Tunnel. The experimental results were used to calculate 17 quantities that included mean and fluctuating velocities, Reynolds stresses, mean and fluctuating dye fluorescence intensities (proportional to concentration), and fluctuating velocity and dye concentration correlations. An uncertainty analysis was performed to establish confidence levels in the experimental results. In general, uncertainties in mean velocities varied between 1 and 7 percent of free-stream velocity; uncertainties in fluctuating velocities varied between 1 and 5 percent of reference values. The results show characteristics that are unique to each type of flow.
Configuration and analysis of robust header compression in UMTS (2004)

ROHC Bormann C., et al. (2001) is the new standard for header compression proposed by the IETF (Internet engineering task force) to compress different protocol headers. ROHC needs to be configured to afford the changes in the characteristics of the UMTS radio link and to enable a better compression of the IPv6 flows. In this document we will introduce the characteristics and the behavior of ROHC. Also we study the compression parameters that are recommended as implementation dependent in the ROHC specification and we show how to configure them. This study can help to improve the efficiency and robustness of ROHC when it is used in scarce resources links, such as UMTS.
Theoretical Analysis of Image Processing Using Parameter-Tuning Stochastic Resonance Technique (2007)

Parameter-tuning stochastic resonance has been successfully applied to one-dimensional signal processing. This paper explores the feasibility to extend this technique for image processing. Based on the two-dimensional nonlinear bistable dynamic system, the equation satisfied by the system output probability density function is derived for the first time. The corresponding equation for the one-dimensional system is the famous Fokker-Planck-Kolmogorov (FPK) equation. The stationary solution, eigenvalues and eigenfunctions of this equation are then investigated. The upper bound of the system response speed and the related calculation algorithm which are necessary for the applications of this technique to image processing are also proposed in this paper. Finally, the potential applications of this approach in image processing and some future research are suggested.
Intercalated cytosine motif and novel adenine clusters in the crystal structure of the Tetrahymena telomere (1998)

The cytosine-rich strand of the Tetrahymena telomere consists of multiple repeats of sequence d(AACCCC). We have solved the crystal structure of the crystalline repeat sequence at 2.5 A resolution. The adenines form two different and previously unknown clusters (A clusters) in orthogonal directions with their counterparts from other strands, each containing a total of eight adenines. The clusters appear to be stable aggregates held together by base stacking and three different base-pairing modes. Two different types of cytosine tetraplexes are found in the crystal. Each four-stranded complex is composed of two intercalated parallel-stranded duplexes pointing in opposite directions, with hemiprotonated cytosine-cytosine (C.C+) base pairs. The outermost C.C+base pairs are from the 5'-end of each strand in one cytosine tetraplex and from the 3'-end of each strand in the other. The A clusters and the cytosine tetraplexes form two alternating stacking patterns, creating continuous base stacking in two perpendicular directions along the x - and z -axes. The adenine clusters could be organizational motifs for macromolecular RNA.
Free Salt Dyeing by Treatment of Cotton Fabric Using CarboxyethylChitosan and Synthesized Direct Dyes to Enhance Dyeing Properties andAntibacterial Activity (2023)

Cotton fabrics treated with carboxyethyl chitosan and dyed with direct dyes were found to have higher antibacterial activity upon a concentration of 2.5 wt.%. In addition, the antibacterial activity towards Gram-positive bacteria was reported to be more than Gram-negative bacteria.
Allergisches Kontaktekzem nach intravesikaler Instillation von Mitomycin C: Ein Fallbericht mit Literaturüberblick (2006)

Einleitung: Mitomycin C ist ein alkylierendes Chemotherapeutikum, das standardmäßig zur Rezidivprophylaxe von oberflächlichen Urothelkarzinomen der Harnblase intravesikal instilliert wird. Hautreaktionen nach der Instillationstherapie sind in der Literatur beschrieben, wobei deren Pathomechanismus nicht eindeutig geklärt ist. Anhand eines Falles aus unserer Klinik führten wir diagnostische Testungen und eine Literaturrecherche durch, um Informationen über die Ätiologie und Inzidenz solcher Hautreaktionen zu erhalten.
Immunoregulation through membrane proteins modified by reducing conditions induced by immune reactions (2012)

Selected disulfide bonds in membrane proteins are labile and are thus susceptible to changes in redox potential and/or the presence of thiol isomerase enzymes. Modification of these disulfide bonds can lead to conformational changes of the protein that in turn may alter protein activity and function. This occurs in the entry of several enveloped viruses into their host cells, e.g. HIV, hepatitis C virus and Newcastle disease virus. Labile disulfide bonds are also important in platelet activation, cytokine signalling and in a variety of diseases including cancer and arthritis. In this review we will concentrate on recent advances in understanding the conditions that lead to disulfide bond reduction in membrane proteins and their effects in regulating immune function.
Synthesis of Acetylated Konjac Glucomannan and Effect of Degree of Acetylation on Water Absorbency (2001)

Konjac glucomannan was acetylated with acetic anhydride under different conditions to reduce the unusually high water absorbency of native konjac. The dependence of the degree of substitution (DS) on the reaction conditions and the influence of the DS on the water absorbency were investigated. The most efficient method for the acetylation was refluxing konjac in acetic anhydride in the presence of sodium hydroxide catalyst. The water absorbency rapidly decreased with increasing DS. Fully acetylated product was obtained within 12 h, which exhibited 1.0 g/g water absorbency vs the 105.4 g/g absorbency of native konjac. Because of the exponential decrease of water absorbency with increasing DS, a relatively small DS is sufficient to significantly suppress the absorption of water.
In Vivo Biological Purging for Lymph Node Metastasis of Human Colorectal Cancer by Telomerase-Specific Oncolytic Virotherapy (2010)

Our results indicate that intratumoral injection of OBP-301 mediates effective in vivo purging of metastatic tumor cells from regional lymph nodes, which may help optimize treatment of human cancer, especially gastrointestinal malignancies.
从“邮件门”谈数据管理的三点启示 (2015)

当事情没有按计划进行时,总会有人说,亡羊补牢,未为晚矣。最近,有人披露希拉里·克林顿在担任美国国务卿期间没有使用政府专用电子邮箱,而是自己的私人邮箱。这一做法遭到了众人的强烈反对。希拉里的这一做法,其动机引来了诸多激烈的争论。但事实是,每个机构(从政府到私营部门)都要了解我们进行信息管理的必要方法。毕竟,希拉里·克林顿犯了企业环境中常见的错误,因为使用私人邮箱和设备处理公务将把机构置于风险之中。但对于其行为尤其是动机的争论,并不能从根本上解决将风
Beneficial Effect of Angiotensin-Blocking Agents on Graft Fibrosis in Hepatitis C Recurrence after Liver Transplantation (2004)

The administration of angiotensin-blocking agents may be beneficial to reduce the development of graft fibrosis in hepatitis C recurrence after liver transplantation.
IEC 61850-based WLAN peer-to-peer feeder protection improvement in smart grid substation automation system (2015)

The development of a computational platform of a communication network for an automation system using the precepts of IEC 61850 has become a great trend in substation automation systems (SASs) research. Recent developments in wireless communication technologies, especially the IEEE802.11 have enabled cost-effective remote control systems with a capability of monitoring, control and protection in the real-time operating conditions of substations. The message delay and throughput in substation automation while using the WLAN and smart grid must satisfy the standard requirements specified in the IEC 61850-5. In this paper, the end-to-end (ETE) delay of IEC 61850-based messages and operating time of the over current protection using the WLAN-based communication network has been evaluated using Opnet Modeler Edition 18.0.
Evidence for Diversifying Selection on Erythrocyte-Binding Antigens of Plasmodium falciparum and P. vivax (2003)

Malaria parasite antigens involved in erythrocyte invasion are primary vaccine candidates. The erythrocyte-binding antigen 175K (EBA-175) of Plasmodium falciparum binds to glycophorin A on the human erythrocyte surface via an N-terminal cysteine-rich region (termed region II) and is a target of antibody responses. A survey of polymorphism in a malaria-endemic population shows that nucleotide alleles in eba-175 region II occur at more intermediate frequencies than expected under neutrality, but polymorphisms in the homologous domains of two closely related genes, eba-140 (encoding a second erythrocyte-binding protein) and psieba-165 (a putative pseudogene), show an opposite trend. McDonald-Kreitman tests employing interspecific comparison with the orthologous genes in P. reichenowi (a closely related parasite of chimpanzees) reveal a significant excess of nonsynonymous polymorphism in P. falciparum eba-175 but not in eba-140. An analysis of the Duffy-binding protein gene, encoding a major erythrocyte-binding antigen in the other common human malaria parasite P. vivax, also reveals a significant excess of nonsynonymous polymorphisms when compared with divergence from its ortholog in P. knowlesi (a closely related parasite of macaques). The results suggest that EBA-175 in P. falciparum and DBP in P. vivax are both under diversifying selection from acquired human immune responses.
Epithelial Cell Migration and Proliferation Patterns During Initial Wound Closure in Normal Mice and an Experimental Model of Limbal Stem Cell Deficiency (2020)

Our findings show the dimensions of the corneal wound dictate involvement of LSCs. Our data suggest that divergent findings by different groups on the dynamics of wound healing can be in part owing to differences in the wounding models used.
A Multi-accuracy-Level Approximate Memory Architecture Based on Data Significance Analysis (2016)

Approximate memory is a promising technology for emerging recognition, mining and vision applications. These applications require the processing of large volumes of data to achieve energy-efficiency with negligible accuracy loss. This paper proposes a multi-level approximate memory architecture based on data significance analysis. In this architecture, a memory array is divided into several separated banks with different predefined accuracy levels. A key novelty of this work is the design of a memory controller that distributes data to the memory banks according to the results of data significance analysis. When applied to a DCT (Discrete Cosine Transform) processing module, the proposed approximate memory controller can achieve over 60% power saving with onchip memory model of multiple supply voltage SRAM banks, at the cost of a marginal output PSNR (Peak Signal to Noise Ratio) degradation of 3.34 dB.
Peripheral Blood B Cell Subset Skewing Is Associated with Altered Cell Cycling and Intrinsic Resistance to Apoptosis and Reflects a State of Immune Activation in Chronic Hepatitis C Virus Infection (2010)

Chronic hepatitis C virus (HCV) infection is associated with B cell activation, although underlying mechanisms are unclear. To investigate B cell regulation during HCV infection, we measured bulk B cell CpG and Staphylococcus aureus Cowan-induced IgG Ab-secreting cell (ASC) frequency, HCV and tetanus-specific ASC frequency, BCR- and CD40L-dependent CD80/CD86 expression, and activation of memory CD4 cells. Immature transitional, naive, resting memory, mature activated, tissue-like memory, and plasma B cell subset frequencies, cell cycling, and intrinsic apoptosis were quantified. We observed intact or enhanced tetanus-specific and total IgG ASC frequency, serum IgG, BCR- and CD40L-dependent CD80/CD86 expression, and CD40L-dependent bulk B cell activation of memory CD4 cells in HCV infection. HCV-specific ASCs were observed in HCV-infected but not control subjects, although frequencies were lower compared with tetanus-specific cells. Immature transitional and mature activated B cell subset frequencies were increased in HCV-infected subjects, with immature transitional frequency associated with liver inflammation and serum B cell-activating factor. Mature activated B cells less commonly expressed Ki67, more commonly expressed Bcl2, and were more intrinsically resistant to apoptosis, whereas immature transitional B cells more commonly expressed Ki67, the latter associated with plasma HCV level. Taken together, these results indicate that in the setting of chronic HCV infection, a state of activation results in B cell subset skewing that is likely the result of alterations in homeostasis, cell cycling, and intrinsic resistance to apoptosis and that results in an overall intact or enhanced B cell response to BCR and CD40L.
Correction: Gastric peroral endoscopic pyloromyotomy versus gastric electrical stimulation in the treatment of refractory gastroparesis: a propensity score-matched analysis of long term outcomes (2020)

Correction to: Gastric peroral endoscopic pyloromyotomy versus gastric electrical stimulation in the treatment of refractory gastroparesis: a propensity score-matched analysis of long term outcomesEndoscopy 2020; 52(05): 349-358DOI: 10.1055/a-1111-8566
Selective depletion of alloreactive donor T cells by anti-CD25immunotoxin in allogeneic transplantation (2005)

Selective depletion of alloreactive donor T cells by anti-CD25
immunotoxin in allogeneic transplantation
Dependence of stoichiometry of lithium niobate nanocrystals on initial lithium to niobium ratios in the synthesis step (2017)

Ferroelectric nanocrystals show promise for application in forming hybridized nonlinear materials with liquid crystals. It is well known that bulk single crystals of lithium niobate (LiNbO3) are most easily grown in a congruent (lithium-deficient) form but can also be grown in a stoichiometric form. This is controlled by the specific growth conditions and the stoichiometric ratio r = MLi/(MLi + MNb), where M is the molar fraction. This work explores the dependence of the stoichiometry of LiNbO3 nanocrystals on the value of r in the synthesis step. Batches of LiNbO3 nanocrystals were synthesized using a sol-gel method. The nanocrystals were analysed via SEM and Raman spectroscopy to gain information about their morphology, stoichiometry, defect content, and phase. For bulk crystals, previous work has demonstrated that the spectral widths of specific Raman modes strongly depend on r. For the nanocrystals, the Raman spectra indeed reveal that the resultant nanocrystal stoichiometry depends on the initial r used in the synthesis step. In addition, a close examination of the Raman spectra reveals the presence of an extra phase in batches with r > 55%. Somewhat counterintuitively, this phase is identified by its Raman spectra to be LiNb3O8, a relatively lithium-poor phase compared to LiNbO3. Avoiding this extra phase, we find that high quality, roughly spherical LiNbO3 nanocrystals can be synthesized for r between 52 and 54%.
A novel method for preparation of soluble a-keratin proteins in a high yield (2007)

Wool keratin fibers were solubilized in water without any degradation of wool keratin proteins by the derivatization of disulfide (SS) bonds of cystine residues to carboxymethyl alanyl disulfide (CMAD) groups. After the reduction of wool with 0.2M thioglycolic acid (TGA) in 8M urea at pH 10 for 48h at 25C, 0 .2M dithiodiglycolic acid (DTDG) was added to the solution containing swollen wool fibers and gently stirred for 24h, and then adjusted to pH7.0 with acetic acid, and finally 0.2M sodium bromate was added slowly to the neutral solution, and then the solution was filtered to remove residues after standing for 24h. The filterate containing soluble CMAD wool keratin proteins was fractionated using Sephadex G25, and the fractions were freeze-dried before weighing. The yield obtained was 95.2% on the basis of dry wool fiber. The yield was found to be functions not only of the concentrations of TGA and DTDG, but also the time of reduction and oxidation and pH as well. SDS-gel electrophoresis patterns of CMAD wool keratin proteins prepared below pH 10 were very similar to the wool protein derivatives. FT-IR showed that the soluble wool keratin proteins contain considerable amount of carboxyl groups associated with the CMAD side chain.
Palm Oil (2005)

Abstract The rapid expansion in world production of palm oil over the last three decades has attracted the attention of the oils and fats industry. Many are interested to know how palm oil has been able to compete successfully to gain an increasing share of the international oils and fats markets. The increasing importance of palm oil has naturally led to a steady buildup of scientific, techinical, and trade data and information. This chapter will provide the reader with an understanding of the role of the palm oil industry in the international oils and fats market, the technology involved in extracting and processing of the oil, and the various quality parameters useful in understanding the applications of palm oil products. Some of the common applications of palm oil in food and nonfood end products are described.
Identification of the Spectrin Subunit and Domains Required for Formation of Spectrin/Adducin/Actin Complexes (1996)

Adducin is an actin-binding protein that has been proposed to function as a regulated assembly factor for the spectrin/actin network. This study has addressed the question of the subunit and domains of spectrin required for formation of spectrin/adducin/actin complexes in in vitro assays. Quantitative evidence is presented that the beta-spectrin N-terminal domain plus the first two alpha-helical domains are required for optimal participation of spectrin in spectrin/adducin/actin complexes. The alpha subunit exhibited no detectable activity either alone or following association with beta-spectrin. The critical domains of beta-spectrin involved in complex formation were determined using recombinant proteins expressed in bacteria. The N-terminal domain (residues 1-313) of beta-spectrin associated with F-actin with a Kd of 26 microM, and promoted adducin binding to F-actin with half-maximal activation at 110 nM. Addition of the first alpha-helical domain (residues 1-422) lowered the Kdfor F-actin by 4-fold to 6 microM, but also reduced the capacity by 3-fold and had no effect on interaction with adducin. Further addition of the second alpha-helical domain (residues 1-528) did not alter binding to F-actin but resulted in a 2-fold increased activity in promoting adducin binding with half-maximal activation at 50 nM. Addition of up to eight additional alpha-helical domains (residues 1-1388) resulted in no further change in F-actin binding or association with adducin. These results demonstrate an unanticipated role of the first repeat of beta-spectrin in actin binding activity and of the second repeat in association with adducin/actin, and imply the possibility of an extended contact between adducin, spectrin, and actin involving several actin subunits.
Molecular Expression and Characterization of Erythroid-Specific 5-Aminolevulinate Synthase Gain-of-Function Mutations Causing X-Linked Protoporphyria (2013)

X-linked protoporphyria (XLP) (MIM 300752) is a recently recognized erythropoietic porphyria due to gain-of-function mutations in the erythroid-specific aminolevulinate synthase gene (ALAS2). Previously, two exon 11 small deletions, c.1699_1670ΔAT (ΔAT) and c.1706_1709ΔAGTG (ΔAGTG), that prematurely truncated or elongated the ALAS2 polypeptide, were reported to increase enzymatic activity 20- to 40-fold, causing the erythroid accumulation of protoporphyrins, cutaneous photosensitivity and liver disease. The mutant ΔAT and ΔAGTG ALAS2 enzymes, two novel mutations, c.1734ΔG (ΔG) and c.1642C>T (p.Q548X), and an engineered deletion c.1670-1671TC>GA p.F557X were expressed, and their purified enzymes were characterized. Wild-type and ΔAGTG enzymes exhibited similar amounts of 54- and 52-kDa polypeptides on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), whereas the ΔAT and p.F557X had only 52-kDa polypeptides. Compared to the purified wild-type enzyme, ΔAT, ΔAGTG and Q548X enzymes had increased specific activities that were only 1.8-, 3.1- and 1.6-fold, respectively. Interestingly, binding studies demonstrated that the increased activity Q548X enzyme did not bind to succinyl-CoA synthetase. The elongated ΔG enzyme had wild-type specific activity, kinetics and thermostability; twice the wild-type purification yield (56 versus 25%); and was primarily a 54-kDa form, suggesting greater stability in vivo. On the basis of studies of mutant enzymes, the maximal gain-of function region spanned 57 amino acids between 533 and 580. Thus, these ALAS2 gain-of-function mutations increased the specific activity (ΔAT, ΔAGTG and p.Q548X) or stability (ΔG) of the enzyme, thereby leading to the increased erythroid protoporphyrin accumulation causing XLP.
A Fast and Accurate Plane Detection Algorithm for Large Noisy Point Clouds Using Filtered Normals and Voxel Growing (2010)

International audience
CTA-determined tricuspid annular dilatation is associated with persistence of tricuspid regurgitation after transcatheter aortic valve replacement (2023)

In patients undergoing TAVR for severe AS and concomitant at least moderate TR at baseline, TAD is a predictor of TR persistence, which is associated with increased 2-year all-cause mortality.
Insole pedometer with piezoelectric energy harvester and 2V organic digital and analog circuits (2012)

Energy harvesting is an enabling technology for realizing an ambient power supply for wireless sensor nodes and mobile devices. By using flexible photovoltaic cells and piezoelectric films, we can readily harvest ambient energy if flexible energy harvesters can be realized. Conventional silicon circuits, however, are not best suited to realizing flexible large-area energy harvesters because they are not mechanically conformable to uneven surfaces such as shoes. To address this challenge, we propose an organic insole pedometer with a piezoelectric energy harvester in this paper as the first step toward ambient energy harvesting using organic flexible electronics.