gebhart/patrepeval huggingface dataset:
Direct Bronsted acid-catalyzed derivatization of cellulose with poly(L-lactic acid) and D-mandelic acid (2007)

Article Direct Bronsted acid-catalyzed derivatization of cellulose with poly(L-lactic acid) and D-mandelic acid was published on May 1, 2007 in the journal Nordic Pulp & Paper Research Journal (volume 22, issue 2).
A nationwide study on parathyroid carcinoma (2017)

PC associates with severe primary hyperparathyroidism and must be suspected if calcium ≥1.77 mmol/l. The prevalence of CDC73 germline mutations in PC and APA in Finland is 6%. PC has distinct histopathological characteristics and its incidence has increased over the past decades.
THE PHYSICAL STATES OF ANHYDROUS SODIUM SOAPS (1943)

Density measurements and differential cooling curves have been carried out on sodium stearate and sodium oleate over a range of temperatures. For sodium stearate, the genotypical or unidimensional melting point at 70 °C. found by Thiessen et al. has been corroborated. A large transition has been noted at about 100 °C. and it is suggested that this phase transition is due to a melting in a second dimension at right angles to the molecular axis. A further large transition has been found at 125° to 130 °C. leading to a plastic state in the soap, and it is suggested that this transition point denotes the essential completion of bidimensional melting of the lattice. No further considerable phase change was found up to about 200 °C., when disruption of the polar bonds probably occurs to effect complete disruption of the lattice to the liquid crystalline state. Only the latter transition point was found for sodium oleate at about 135 °C.
Superresolution microscope image reconstruction by spatiotemporal object decomposition and association: application in resolving t-tubule structure in skeletal muscle (2014)

One key factor that limits resolution of single-molecule superresolution microscopy relates to the localization accuracy of the activated emitters, which is usually deteriorated by two factors. One originates from the background noise due to out-of-focus signals, sample auto-fluorescence, and camera acquisition noise; and the other is due to the low photon count of emitters at a single frame. With fast acquisition rate, the activated emitters can last multiple frames before they transiently switch off or permanently bleach. Effectively incorporating the temporal information of these emitters is critical to improve the spatial resolution. However, majority of the existing reconstruction algorithms locate the emitters frame by frame, discarding or underusing the temporal information. Here we present a new image reconstruction algorithm based on tracklets, short trajectories of the same objects. We improve the localization accuracy by associating the same emitters from multiple frames to form tracklets and by aggregating signals to enhance the signal to noise ratio. We also introduce a weighted mean-shift algorithm (WMS) to automatically detect the number of modes (emitters) in overlapping regions of tracklets so that not only well-separated single emitters but also individual emitters within multi-emitter groups can be identified and tracked. In combination with a maximum likelihood estimator method (MLE), we are able to resolve low to medium density of overlapping emitters with improved localization accuracy. We evaluate the performance of our method with both synthetic and experimental data, and show that the tracklet-based reconstruction is superior in localization accuracy, particularly for weak signals embedded in a strong background. Using this method, for the first time, we resolve the transverse tubule structure of the mammalian skeletal muscle.
Logistics systems modeling and simulation (2011)

Modern logistics systems are much more than simply networks of material flow. They involve collaboration between firms that are also competitors. The supply chain can be a key consideration in product design, with its design and operations influenced by concerns about uncertain energy costs, sustainability, economic security, and other complex issues. Because of these and other considerations, the contemporary practice in which an analysis model is the first model of the logistics system is no longer feasible. Rather, what is required for a sustainable practice of simulation in logistics is a model-based approach which begins with a formal language for capturing a defining description of the logistics system itself. This formal language must be sufficiently accessible to the logistics systems stakeholders so that they can validate the resulting system description. The resulting descriptive model will be the basis for subsequent analyses, including simulation. In this context, we address the requirements for such a formal language, describe our initial progress in developing such a language for logistics systems, and place it in the context of prior work on reference models.
Practical outpatient pharmacotherapy for alcohol use disorder (2018)

Alcohol use disorder (AUD) is commonly encountered in clinical practice. A combination of psychosocial intervention and pharmacotherapy is the cornerstone of AUD treatment. Despite their efficacy, safety and cost-effectiveness, clinicians are reluctant to prescribe medications to treat individuals with AUD. Given the high rate of relapse with psychosocial intervention alone, increasing patient access to this underutilized treatment has the potential to improve clinical outcome in this difficult-to-treat population. Herein, we provide practical pharmacotherapy strategies to improve treatment outcome for AUD. We review the efficacy and side effects of both on- and off-label agents with a particular focus on clinical applicability. Recommendations are supported by findings from randomized controlled trials (RCT) and meta-analyses selected to be representative, where possible, of current treatment guidelines. The goal of this paper is to help readers use pharmacotherapy with greater confidence when treating patients with AUD.
Mechanically induced image rotation: analogy of the Faraday effect for Orbital Angular Momentum (2011)

A spinning medium is predicted to induce a slight rotation in a transmitted image. We amplify this effect by use of ruby as a slow light medium, giving image rotations of several degrees. In the orbital angular momentum basis set such rotations are analogous to the Faraday effect.
Detection of Single Versus Multiple Antenna Transmission Systems Using Pilot Data (2016)

In this paper, we consider the problem of classifying the transmission system when it is not known a priori whether the transmission is via a single antenna or multiple antennas. The receiver is assumed to be employed with a known number of antennas. In a data frame transmitted by most multiple input multiple output (MIMO) systems, some pilot or training data are inserted for symbol timing synchronization and estimation of the channel. Our goal is to perform MIMO transmit antenna classification using this pilot data. More specifically, the problem of determining the transmission system is cast as a multiple hypothesis testing problem where the number of hypotheses is equal to the maximum number of transmit antennas. Under the assumption of receiver having the exact knowledge of pilot data used for timing synchronization and channel estimation, we consider maximum likelihood (ML) and correlation test statistics to classify the MIMO transmit system. When only probabilistic knowledge of pilot data is available at the receiver, a hybrid ML-based test statistic is constructed using the expectation-maximization algorithm. The performance of the proposed algorithms is illustrated via simulations and comparative merits of different techniques in terms of the computational complexity and performance are discussed.
Evolution of treatment for rheumatoid arthritis (2012)

Treatment for RA has changed profoundly over the past 25 years, evolving from a strategy of providing symptomatic relief, to implementation of therapeutic regimens that impact disease activity and ultimately have been shown to slow or arrest structural joint damage. Drug therapy for RA has evolved from salicylates, to NSAIDs, CSs, DMARDs, MTX, and finally to biologic response modifiers. MTX has become the initial drug of choice in most patients with RA, and some do well on MTX monotherapy without the addition of other agents. Combination regimens including MTX and other conventional DMARDs may be an effective early approach to treatment of RA. The biologic response modifiers (biologics) became available in the late 1990s, based on our understanding of the molecular mediators of synovial inflammation in RA. The first biologics inhibited TNF-α, a cytokine active in host defences against some infections and malignancies, but which also promotes inflammation and bone erosion. Inhibitors of TNF-α are mostly given with MTX, although some can be given as monotherapy. Studies consistently show that combination MTX + TNF-α inhibitor therapy leads to better outcomes than with either agent alone. Tight control strategies, employing objective measures, also lead to improved outcomes. When patients fail treatment with one or more TNF-α inhibitor + MTX, a number of other possible alternatives may be tried, including treatment with biologics having other mechanisms, such as antibodies to certain ILs, other cytokines and inflammatory mediators. Current therapy for RA is such that progression from symptom onset to significant disability is now no longer inevitable, and RA patients can anticipate comfortable and productive lives on medical therapy.
Antiproliferative effect of extracts and pyranonaphthoquinones obtained from Cipura paludosa bulbs (2015)

Cipura paludosa bulbs produce active principles with relevant antiproliferative potential, such as naphthoquinone derivatives, identified as eleutherine, isoeleutherine, and eleutherol. This is the first report indicating C. paludosa with antiproliferative potential.
Exact analysis of low-finesse multimode fiber extrinsic Fabry-Perot interferometers (2004)

A straightforward theory is presented to accurately model the light inferences in a low-finesse multimode fiber extrinsic Fabry-Perot (FP) interferometer. The effect on the fringe visibility of the gap length, sensor structure imperfections, and modal power distributions is explored. The analysis is particularly useful in the design and optimization of sensors that use an extrinsic FP cavity as the sensing element.
Density-Weighted Concentric Ring Trajectory using simultaneous multi-band acceleration: 3D Metabolite-cycled Magnetic Resonance Spectroscopy Imaging at 3 T (2019)

Abstract Simultaneous multi-slice or multi-band parallel imaging is frequently used in fMRI to accelerate acquisition. In this study, we propose a new a non-water-suppressed multi-band MRSI using a density weighted concentric ring trajectory (DW-CRT) acquisition. The properties of multi-band acquisition scheme were compared against single-band acquisition in phantoms and in-vivo experiments. High-quality spectra were acquired for all simultaneously acquired three slices from a limited volume of interest with an in-plane resolution of 5 × 5 mm2 in 19.2 min. The achieved in vivo spectral quality of the multi-band method allowed the reliable metabolic mapping of four major metabolites with Cramér-Rao lower bounds below 50%, using a LCModel analysis. Metabolite maps and LCModel quality metrics were compared between multi-band and single-band acquisition schemes for both phantom and in-vivo measurements. Structural similarity (SSIM) index and conventional coefficient of variance analysis of both phantom and in-vivo measurements revealed a SSIM index higher than 0.83, corresponding to a coefficient of variance of less than 30%. These findings demonstrate that our multi-band DW-CRT MRSI demonstrate a multi-band acceleration, simultaneously acquired 3 slices, with no apparently loss in spectral quality, reducing scan time by a factor of 3 without any significant penalty.
Untangling text data mining (1999)

The possibilities for data mining from large text collections are virtually untapped. Text expresses a vast, rich range of information, but encodes this information in a form that is difficult to decipher automatically. Perhaps for this reason, there has been little work in text data mining to date, and most people who have talked about it have either conflated it with information access or have not made use of text directly to discover heretofore unknown information.
Significant contribution of phenyl centroid···I–C(sp2) Coulombic donor–acceptor attractions to the buildup of a crystal structure (2004)

The X-ray crystallographic analysis of racemate 5 revealed distinct phenyl centroid···I–C(sp2) Coulombic dono–acceptor attractions, which are responsible for the inhibition of a certain mode of polymorphic transition inducing Preferential Enrichment.
Localization Procedures in Patients With Persistent or Recurrent Hyperparathyroidism (1994)

We currently recommend using ultrasonography and technetium Tc99m sestamibi scanning and magnetic resonance imaging for patients with recurrent or persistent HPT. Selective venous catheterization with a parathyroid hormone assay is done selectively. Localization tests decrease morbidity and improve overall results in these patients.
Functionalized hexagonal boron nitride nanomaterials: emerging properties and applications (2016)

Functionalization is an important way to breed new properties and applications for a material. This review presents an overview of the progresses in functionalized hexagonal boron nitride (h-BN) nanomaterials. It begins with an introduction of h-BN structural features, physical and chemical properties, followed by an emphasis on the developments of BN functionalization strategies and its emerging properties/applications, and ends with the research perspectives. Different functionalization methods, including physical and chemical routes, are comprehensively described toward fabrication of various BN derivatives, hetero- and porous structures, etc. Novel properties of functionalized BN materials, such as high water solubility, excellent biocompatibility, tunable surface affinities, good processibility, adjustable band gaps, etc., have guaranteed wide applications in biomedical, electronic, composite, environmental and "green" energy-related fields.
Experimental study on permeable dam technique to control rural non-point pollution in Taihu basin (2006)

In order to control rural non-point pollution in Taihu basin, the permeable dam (PD)technique which combines constructed wetlands principles and rapid filtration mechanics was designed. The PD technique can bear shock load of water quality and quantity of rural non-point pollution by utilizing riverway cubage. Through the manipulative seepage of dam, water head is afforded for latter treatment units. The results of four months' running experiments showed that the seepage calculation of permeable dam was adapted to be calculated by the trapezoidal seepage, and the PD met the prospective requirement of holding a 14000m~3 runoff which occurred once per five days. The TN and TP removal rate of PD were 15.59% and 23.44%, respectively.
Multi-Pole Components of Magnetic Field in Dipole Magnets Wound With High $T_{\rm c}$ Superconductor Tape and Feasibility of Their Accelerator Applications (2010)

Applications of high superconductors to accelerator magnets are attractive from the viewpoint of cooling cost reduction and that of generating very high magnetic field at low temperature. However, in magnets using cosine-theta like coils, three-dimensional shape of coil ends and magnetic field quality might be concerns, because most of practical high superconductors are with flat tape shape. We studied the field quality of dipole magnets wound with high superconductor tapes. Case studies on magnetic field design were made for dipole magnets wound with coated conductors: we designed two magnets and calculated multi-pole components of the magnetic field to evaluate their field qualities. The torsion/bending tolerance of coated conductors was studied experimentally to clarify the feasibility of three-dimensional winding. The influence of the shielding current in high superconductor tapes on field quality was discussed based on the numerical electromagnetic field analysis of superconductors.
Efficient geometrically exact continuous collision detection (2012)

Continuous collision detection (CCD) between deforming triangle mesh elements in 3D is a critical tool for many applications. The standard method involving a cubic polynomial solver is vulnerable to rounding error, requiring the use of ad hoc tolerances, and nevertheless is particularly fragile in (near-)planar cases. Even with per-simulation tuning, it may still cause problems by missing collisions or erroneously flagging non-collisions. We present a geometrically exact alternative guaranteed to produce the correct Boolean result (significant collision or not) as if calculated with exact arithmetic, even in degenerate scenarios. Our critical insight is that only the parity of the number of collisions is needed for robust simulation, and this parity can be calculated with simpler non-constructive predicates. In essence we analyze the roots of the nonlinear system of equations defining CCD through careful consideration of the boundary of the parameter domain. The use of new conservative culling and interval filters allows typical simulations to run as fast as with the non-robust version, but without need for tuning or worries about failure cases even in geometrically degenerate scenarios. We demonstrate the effectiveness of geometrically exact detection with a novel adaptive cloth simulation, the first to guarantee to remain intersection-free despite frequent curvature-driven remeshing.
Development and Testing of a Method for the Systematic Discovery and Utilization of Novel QTLs in the Production of Improved Crop Varieties: Tomato as a Model System (1995)

Modern cultivated varieties carry only a small fraction of the variation present in the gene pool. The narrow genetic basis of modern crop plants is a result of genetic bottlenecks imposed during early domestication and modern plant breeding. The wild ancestors of most crop plants can still be found in their natural habitats and Germplasm Centers have been established to collect and maintain this material. These wild and unadapted resources can potentially fuel crop plant improvement efforts for many years into the future (Tanksley and McCouch 1997). Unfortunately, scientists have been unable to exploit the majority of the genetic potential warehoused in germplasm repositories. This is especially true as regards to the improvement of quantitative traits like yield and quality. One of the major problems is that much of the wild germplasm is inferior to modern cultivars for many of the quantitative traits that breeders would like to improve. Our research, focusing on the tomato as a model system, has shown that despite their inferior phenotypes, wild species are likely to contain QTLs that can substantially increase the yield and quality of elite cultivars (de Vicente and Tanksley 1992, Eshed and Zamir 1994, Eshed et al. 1996). Using novel population structures of introgression lines (ILs; Eshed and Zamir 1995) and advanced backcross lines (AB; Tanksley et al. 1996) we identified and introduced valuable QTLs from unadapted germplasm into elite processing tomato varieties. Populations involving crosses with five Lycopersicon species (L. pennellii (Eshed and Zamir 1994; Eshed et al. 1996; Eshed and Zamir 1996), L. hirsutum (Bernacchi et al. 1998), L. pimpinellifolium (Tanksley et al. 1996), L. parviflorum (unpub.), L. peruvianum (Fulton et al. 1997) have been field and laboratory tested in a number of locations around the world. QTLs from the wild parent were identified that improve one or more of the key quantitative traits for processing tomatoes (yield, brix, sugar and acid composition and earliness) by as much as 10-30%. Nearly isogenic lines (QTL-NILs) have been generated for a subset of these QTLs. Each QTL-NIL contains the entire genome of the elite cultivated parent except for a segment (5-40 cM) of the wild species genome corresponding to a specific QTL. The genetic material and information that was developed in this program is presently used by American and Israeli seed companies for the breeding of superior varieties. We expect that in the next few years these varieties will make a difference in the marketplace.
Chinese clinical guidelines for continuous glucose monitoring (2018 edition) (2019)

Blood glucose monitoring is an important part of diabetes management. Continuous glucose monitoring (CGM) technology has become an effective complement to conventional blood glucose monitoring methods and has been widely applied in clinical practice. The indications for its use, the accuracy of the generated data, the interpretation of the CGM results, and the application of the results must be standardized. In December 2009, the Chinese Diabetes Society (CDS) drafted and published the first Chinese Clinical Guideline for Continuous Glucose Monitoring (2009 edition), providing a basis for the standardization of CGM in clinical application. Based on the updates of international guidelines and the increasing evidence of domestic studies, it is necessary to revise the latest CGM guidelines in China so that the recent clinical evidence can be effectively translated into clinical benefit for diabetic patients. To this end, the CDS revised the Chinese Clinical Guideline for Continuous Glucose Monitoring (2012 Edition) based on the most recent evidence from international and domestic studies.
Measurements of average heat-transfer and friction coefficients for subsonic flow of air in smooth tubes at high surface and fluid temperatures (1951)

An investigation of forced-convection heat transfer and associated pressure drops was conducted with air flowing through smooth tubes for an over-all range of surface temperature from 535 degrees to 3050 degrees r, inlet-air temperature from 535 degrees to 1500 degrees r, Reynolds number up to 500,000, exit Mach number up to 1, heat flux up to 150,000 btu per hour per square foot, length-diameter ratio from 30 to 120, and three entrance configurations. Most of the data are for heat addition to the air; a few results are included for cooling of the air. The over-all range of surface-to-air temperature ratio was from 0.46 to 3.5.
Abstract 16528: Impact of Alirocumab on Apolipoprotein B, Non-High-Density Lipoprotein Cholesterol, and Triglycerides in Patients With and Without Moderate Chronic Kidney Disease (2016)

Introduction: Mixed dyslipidemia, characterized by high triglycerides (TGs) and non-high-density lipoprotein cholesterol (non-HDL-C), is frequently observed in chronic kidney disease (CKD) patients...
Plasma complement and vascular complement deposition in patients with coronary artery disease with and without inflammatory rheumatic diseases (2017)

The independent association of IRD status with MCI and the observed C3d deposition supports the unique relationship between rheumatic disease, and, in particular, SLE with the complement system. Exaggerated systemic and vascular complement activation may accelerate CVD, serve as a CVD biomarker, and represent a target for new therapies.