gebhart/patrepeval huggingface dataset:
The Morphology of Reionization in a Dynamically Clumpy Universe (2022)

A recent measurement of the Lyman-limit mean free path at $z = 6$ suggests it may have been very short, motivating a better understanding of the role that ionizing photon sinks played in reionization. Accurately modeling the sinks in reionization simulations is challenging because of the large dynamic range required if $\sim 10^4-10^8 M_{\odot}$ gas structures contributed significant opacity. Thus, there is no consensus on how important the sinks were in shaping reionization's morphology. We address this question with a recently developed radiative transfer code that includes a dynamical sub-grid model for the sinks based on radiative hydrodynamics simulations. Compared to assuming a fully pressure-smoothed IGM, our dynamical treatment reduces ionized bubble sizes by $10-20\%$ under typical assumptions about reionization's sources. Near reionization's midpoint, the 21 cm power at $k \sim 0.1$ $h$Mpc$^{-1}$ is similarly reduced. These effects are more modest than the $30-60\%$ suppression resulting from the higher recombination rate if pressure smoothing is neglected entirely. Whether the sinks played a significant role in reionization's morphology depends on the nature of its sources. For example, if reionization was driven by bright ($M_{\rm UV} &lt; -17$) galaxies, the sinks reduce the large-scale 21 cm power by at most $20\%$, even if pressure smoothing is neglected. Conveniently, when bright sources contribute significantly, the morphology in our dynamical treatment can be reproduced accurately with a uniform sub-grid clumping factor that yields the same ionizing photon budget. By contrast, if $M_{\rm UV} \sim -13$ galaxies drove reionization, the uniform clumping model can err by up to $40\%$.
Holmium laser resection of the prostate (HoLRP): 2-year follow-up data. (2001)

Medium-term clinical results of HoLRP confirm that patient satisfaction is excellent, with complication rates similar to those historically reported for transurethral resection of the prostate (TURP). The HoLRP technique is an effective and durable surgical alternative to standard TURP.
Storage-based Intrusion Detection: Watching storage activity for suspicious behavior (2002)

Storage-based intrusion detection allows storage systems to transparently watch for suspicious activity.Storage systems are well-positioned to spot several common intruder actions, such as adding backdoors, inserting Trojan horses, and tampering with audit logs.Further, an intrusion detection system (IDS) embedded in a storage device continues to operate even after client systems are compromised.This paper describes a number of specific warning signs visible at the storage interface.It describes and evaluates a storage IDS, embedded in an NFS server, demonstrating both feasibility and efficiency of storage-based intrusion detection.In particular, both the performance overhead and memory required (40 KB for a reasonable set of rules) are minimal.With small extensions, storage IDSs can also be embedded in block-based storage devices.
A new Raman cross section measurement technique monitors the tyrosine environmental dependence of the electromagnetic field strength (1991)

We have developed a new Raman spectroscopic technique which can be used to determine relative Raman intensities as a function of the liquid medium refractive index. We utilize teflon as an external standard. The refractive index dependence of the solid angle of light collection disappears in our sampling geometry and the self-absorption bias is minimized. We observe a refractive index dependence for the Raman intensity for N-acetyl-L-tyrosinamide (NATYR) close to that calculated using previously derived relations which determine the effect of the refractive index on the electromagnetic field strength and upon the Raman scattered intensities. This dependence gives a ca. 25% increased resonance Raman intensity of NATYR in ethylene glycol compared to water for ca. 243 nm excitation. The strong dependence of the Raman intensity upon the environment suggests that UV resonance Raman intensity measurements can be used to monitor the average environmental refractive index of aromatic amino acids in proteins.
Genome-Wide Protein Function Prediction through Multi-Instance Multi-Label Learning (2014)

Automated annotation of protein function is challenging. As the number of sequenced genomes rapidly grows, the vast majority of proteins can only be annotated computationally. Nature often brings several domains together to form multi-domain and multi-functional proteins with a vast number of possibilities, and each domain may fulfill its own function independently or in a concerted manner with its neighbors. Thus, it is evident that the protein function prediction problem is naturally and inherently Multi-Instance Multi-Label (MIML) learning tasks. Based on the state-of-the-art MIML algorithm MIMLNN, we propose a novel ensemble MIML learning framework EnMIMLNN and design three algorithms for this task by combining the advantage of three kinds of Hausdorff distance metrics. Experiments on seven real-world organisms covering the biological three-domain system, i.e., archaea, bacteria, and eukaryote, show that the EnMIMLNN algorithms are superior to most state-of-the-art MIML and Multi-Label learning algorithms.
Geosmithia argillacea: An Emerging Cause of Invasive Mycosis in Human Chronic Granulomatous Disease (2011)

We report the first cases of invasive mycosis caused by G. argillacea in CGD patients. G. argillacea infections in CGD are often refractory and severe with a high fatality rate. Surgical intervention has been effective in some cases. G. argillacea is a previously underappreciated and frequently misidentified pathogen in CGD that should be excluded when P. variotii is identified morphologically.
Design of turbo-code interleaver using Hungarianmethod (1998)

A method is presented for optimising the structure of the turbo-code interleaver using the Hungarian method (linear sum assignment problem). Numerical results are presented which show a substantial improvement with respect to a random interleaver.
Specific MDR1 P-Glycoprotein Blockade Inhibits Human Alloimmune T Cell Activation In Vitro (2001)

MDR1 P-glycoprotein (P-gp), the multidrug resistance-associated transmembrane transporter, is physiologically expressed by human peripheral immune cells, but its role in cell-mediated immunity remains poorly understood. Here, we demonstrate a novel role for P-gp in alloantigen-dependent human T cell activation. The pharmacologic P-gp inhibitor tamoxifen (1-10 microM) and the MDR1 P-gp-specific mAb Hyb-241 (1-20 microg/ml), which detected surface P-gp on 21% of human CD3(+) T cells and 84% of CD14(+) APCs in our studies, inhibited alloantigen-dependent, but not mitogen-dependent, T cell proliferation in a dose-dependent manner from 40-90% (p < 0.01). The specific inhibitory effect on alloimmune T cell activation was associated with >85% inhibition (p < 0.01) of IL-2, IFN-gamma, and TNF-alpha production in 48-h MLR coculture supernatants. Addition of recombinant human IL-2 (0.1-10 ng/ml) restored proliferation in tamoxifen-treated cocultures. Pretreatment of purified CD4(+) T cells with Hyb-241 mAb before coculture resulted in inhibition of CD4(+) T cellular IFN-gamma secretion. Also, blockade of P-gp on allogeneic APCs inhibited IL-12 secretion. Taken together these results demonstrate that P-gp is functional on both CD4(+) T cells and CD14(+) APCs, and that P-gp blockade may attenuate both IFN-gamma and IL-12 through a positive feedback loop. Our results define a novel role for P-gp in alloimmunity and thus raise the intriguing possibility that P-gp may represent a novel therapeutic target in allograft rejection.
Current Understanding on the Role of Retinal Pigment Epithelium and its Pigmentation (1999)

Retinal pigment epithelium (RPE) is a monolayer of cuboidal cells that is strategically placed between the rod and cone photoreceptors and the vascular bed of the choriocapillaris. It has many important functions, such as phagocytic uptake and breakdown of the shedded photoreceptor membranes, uptake, processing, transport and release of vitamin A (retinol), setting up the ion gradients within the interphotoreceptor matrix, building up the blood-retina barrier, and providing all transport from blood to the retina and back. This short review focuses on the role of the pigment granules in RPE. Although the biology of the pigment granules has been neglected in the past, they do seem to be involved in many important functions, such as protection from oxidative stress, detoxification of peroxides, and binding of zinc and drugs, and, therefore, serve as a versatile partner of the RPE cell. Melanin plays a role in the development of the fovea and routing of optic nerves. New findings show that the melanin granules are connected to the lysosomal degradation pathway. Most of these functions are not yet understood. Deficit of melanin pigment is associated with age-related macula degeneration, the leading cause of blindness.
Novel glassy nematic and chiral nematic oligomers derived from 1,3,5-cyclohexanetricarboxylic and (1R,3S)-(+)-camphoric acids (1994)

Abstract Novel nematic and chiral nematic liquid crystals capable of vitrification have been synthesized using 1,3,5-cyclohexanetricarboxylic and (1R,3S)-(+)-camphoric acids as the base structures to which cyanotolan, cyanobiphenyl, methoxybiphenylbenzoate nematogenic groups, (S)-(−)-1-phenylethylamine and (S)-(+)-1,3-butanediol chiral moieties are attached. Once the glassy state is induced by quenching or controlled cooling from the isotropic state, these liquid crystals showed no detectable tendency towards crystallization upon heating through the glass transition temperature. In all cases, the ΔC p and ΔH c values resulting from the DSC heating scans are comparable to those previously reported for polymer analogues and other low molar mass glassy liquid crystals. In the nematic series with varying spacer lengths, both T g and T c are consistently lower than the linear polymer counterparts, in contrast to the siloxane-based systems. It was also demonstrated that cholesteric mesomorphism can be induced following one of the three approaches: chiral nematic mixture, chiral nematic cyclic cooligomer, and pendant nematogenic groups attached to a chiral ring.
Overcoming RNAi transduction in leukocytes using targeted and stabilized nanoparticles. (2010)

RNAi-based approaches have contributed significantly to the improved understanding of gene expression and function in vitro. The ability to apply these strategies in vivo to validate the role of specific genes in normal or pathological conditions, and to induce gene silencing, has led to new possibilities for using RNAi as a novel therapeutic modality. However, the translation of RNAi from an effective genomic tool into clinical applications has been hindered by the challenge of delivering RNAi molecules to their target tissues by systemic administration, particularly to hematopoietic cells. This feature review describes the current systemic RNAi delivery platforms targeted to leukocytes, with a focus on the integrin-targeted stabilized nanoparticles strategy, which uses leukocyte integrins for the delivery of siRNAs exclusively to cells of the immune system.
Multiple Plastikstents vs. selbst-expandierende Metallstents in der endoskopischen Behandlung von Anastomosenstenosen nach orthotoper Lebertransplantation: Erste Daten einer multizentrischen prospektiv randomisierten Studie (2015)

Ungefähr 10 Prozent aller Patienten nach orthotoper Lebetransplantation (LTx) entwickeln biliäre Anastomosenstenosen. Wir führten eine internationale, multizentrische, sowie prospektiv randomisierte Studie zum Vergleich der endoskopischen Behandlung mittels multiplen Plastik Stents (MPS) und selbst-expandierenden Metallstents (cSEMS) durch.
Adipose Tissue-Derived Stem Cell Imaging Using Cadmium-Free Quantum Dots (2013)

Quantum dots (QDs) have received much attention for biomolecule and cell imaging applications because of their superior optical properties such as high quantum efficiency, size-tunable emission, and resistance to photobleaching process. However, QDs that are commercially available contain cadmium (Cd), a highly toxic element. Thus, the development of Cd-free and less toxic QDs is strongly desired. In this study, we developed Cd-free QDs (ZnS-coated ZnS-AgInS2 solid solution nanoparticles with a sulfo group: ZnS-ZAIS-SO3H) and investigated the ability of this material to label stem cells. ZnS-ZAIS-SO3H could be transduced into mouse adipose tissue-derived stem cells (mASCs) using octaarginine peptides (R8), known as cell-penetrating peptides. The optimal ratio of ZnS-ZAIS-SO3H:R8 was found to be 1:100 for labeling mASCs. More than 80% of mASCs labeled with 500 nM ZnS-ZAIS-SO3H were found to be alive, and the proliferation rates of labeled mASCs were maintained at the same rate as that of nonlabeled mASCs. In addition, no abnormalities in the morphology of mASCs labeled with ZnS-ZAIS-SO3H could be observed. These data suggest that ZnS-ZAIS-SO3H may be effective for the labeling of mASCs.
Letter to the Editor (1999)

and any increase in pressure is prevented by connecting the two femoral arteries with a blood reservoir. Our results I read the nicely written and interesting review by Kojda also indicate that the sympathetic discharge is not affected and Kotteberg I found very interesting the section by the NO-inhibition ''per se'', but, before and after devoted to the chronotropic effects of NO. I agree with the NO-inhibition, it can be reduced to the same extent by the conclusions of the authors that NO has a positive chrono-same increase in pressure. In their paper Ward and Angus tropic effect which has been described and explained.
Table S1 from Glypican-1 Is a Novel Target for Stroma and Tumor Cell Dual-Targeting Antibody–Drug Conjugates in Pancreatic Cancer (2023)

&lt;p&gt;Supplementary Table S1&lt;/p&gt;
Radiotherapy patterns of care in gastric adenocarcinoma: a single institution experience. (2015)

PC has become more prevalent in patients treated at Emory following publication of the MAGIC trial in 2006. OS, but not recurrence rates, has also improved since publication. Although improved survival is suggestive of improved care, the question of optimal treatment regimen remains open. Further prospective comparisons of PC and aCRT are needed to identify patient and disease parameters that may guide therapy selection.
Biocompatibility of poly(ethylene glycol)/poly(acrylic acid) interpenetrating polymer network hydrogel particles in RAW 264.7 macrophage and MG‐63 osteoblast cell lines (2008)

Hydrogel polymers comprise a novel category of synthetic materials being investigated for use in cartilage replacement. One candidate compound, a poly(ethylene glycol)/poly(acrylic acid) (PEG/PAA) interpenetrating polymer network (IPN), was developed for use in corneal prostheses and was recently engineered for potential orthopedic use. The current study examined the effects of particles of this compound on two cell lines (MG-63 osteoblast-like cells and RAW 264.7 macrophages) over a 48-h time course. To mimic the effects of wear debris, particles of the compound were generated and introduced to the cells. In the MG-63 cell line, the particles had no significant effect on cell viability measured by PicoGreen assay and trypan blue exclusion. In contrast, a significant decrease in cell viability was detected in the Raw 264.7 macrophage cells at the final timepoint with the highest concentration of hydrogel (3.0% v:v). A concentration- and time-dependent increase in TNF-alpha release characteristic of other known biocompatible materials was also detected in RAW 264.7 cells, but nitric oxide and interleukin (IL)-1beta showed no response. In addition, the MG-63 cell line demonstrated no IL-6 response. Particles of the PEG/PAA IPN thus seem to stimulate biological responses similar to those in other biocompatible materials.
Cyclic AMP receptor protein and cyclic AMP-dependent protein kinase activity in rabbit peritoneal neutrophils. (1983)

The cAMP receptor protein and cAMP-dependent protein kinase activity in rabbit peritoneal neutrophils have been identified. The cAMP receptor protein in either the plasma membrane or cytosol fractions, identified by photoaffinity labeling with 8-N3-[32P]cAMP, has an apparent molecular weight of 54,000. The cytosol and membrane receptor proteins have apparent dissociation constants for 8-N3-[32P]cAMP of 0.20 microM and 0.06 microM, respectively. The molecular weight and dissociation constant for 8-N3-[32P]cAMP of this cAMP receptor protein are similar to what has been known for RII, the regulatory subunit of the type II cAMP-dependent protein kinase. Unlike the human neutrophils, no evidence of RI activity was detected. cAMP-dependent protein kinase activity was identified by using histone as a substrate. Subcellular fractionation studies showed that the cAMP receptor protein and the cAMP-dependent protein kinase activity are most enriched in the cytosol fraction.
Sim-to-Real Transfer for Biped Locomotion (2019)

We present a new approach for transfer of dynamic robot control policies such as biped locomotion from simulation to real hardware. Key to our approach is to perform system identification of the model parameters μ of the hardware (e.g. friction, center-of-mass) in two distinct stages, before policy learning (pre-sysID) and after policy learning (post-sysID). Pre-sysID begins by collecting trajectories from the physical hardware based on a set of generic motion sequences. Because the trajectories may not be related to the task of interest, presysID does not attempt to accurately identify the true value of μ, but only to approximate the range of μ to guide the policy learning. Next, a Projected Universal Policy (PUP) is created by simultaneously training a network that projects μ to a low-dimensional latent variable η and a family of policies that are conditioned on η. The second round of system identification (post-sysID) is then carried out by deploying the PUP on the robot hardware using task-relevant trajectories. We use Bayesian Optimization to determine the values for η that optimize the performance of PUP on the real hardware. We have used this approach to create three successful biped locomotion controllers (walk forward, walk backwards, walk sideways) on the Darwin OP2 robot.
An Introduction to Random Indexing (2005)

Word space models enjoy considerable attention in current research on semantic indexing. Most notably, Latent Semantic Analysis/Indexing (LSA/LSI; Deerwester et al., 1990, Landauer & Dumais, 1997) has become a household name in information access research, and deservedly so; LSA has proven its mettle in numerous applications, and has more or less spawned an entire research field since its introduction around 1990. Today, there is a rich flora of word space models available, and there are numerous publications that report exceptional results in many different applications, including information retrieval (Dumais et al., 1988), word sense disambiguation (Schutze, 1993), various semantic knowledge tests (Lund et al., 1995, Karlgren & Sahlgren, 2001), and text categorization (Sahlgren & Karlgren, 2004). This paper introduces the Random Indexing word space approach, which presents an efficient, scalable and incremental alternative to standard word space methods. The paper is organized as follows: in the next section, we review the basic word space methodology. We then look at some of the problems that are inherent in the basic methodology, and also review some of the solutions that have been proposed in the literature. In the final section, we introduce the Random Indexing word space approach, and briefly review some of the experimental results that have been achieved with Random Indexing.
Synthesis and Structure of [(C5Me5)2Mo2S4·SO3]: Concerning the Oxidation of Sulfur Ligands in Transition‐Metal Complexes (1987)

The first bidentate thiosulfate ligand was found in the title compound 1. Compound 1 is formed in 17% yield upon oxidation of the SO3-poorer complex in solution with atmospheric oxygen. This reaction could begin with the isomerization of the precursor to complexes with terminal MoS groups.
Comparison of Morphological Measurements Extracted From Digitized Dental Radiographs With Lumbar and Femoral Bone Mineral Density Measurements in Postmenopausal Women (2000)

The MO measurements used in this study were weakly correlated with lumbar spine and femoral BMDs, with no clear trends discernible in this population of postmenopausal women with no or mild periodontal disease.
Fluorescence Enhancement in an Array of "Trapped Rainbows" (2011)

Cancer is one of the life-taking diseases worldwide and among cancer-related death; colorectal cancer is the third most. Though conventional methods of treatment are available, multidrug resistance and side effects are predominant. Physicians and scientists are working side by side to develop an effective medicament, which is safe and cost-effective. However, most failures are obtained when focused on the clinical perspective. This review mainly brings out the correlation between the curcumin and its use for the mitigation of colorectal cancer, the use of curcumin as a chemotherapeutic agent, chemosensitizer, and in a combination and synergistic approach. The pharmacokinetics and pharmacodynamics properties of curcumin and its formulation approach helps in giving an idea to develop new approaches for the treatment of colorectal cancer using curcumin.
Dulaglutide, a long-acting GLP-1 analog fused with an Fc antibody fragment for the potential treatment of type 2 diabetes. (2010)

Dulaglutide (LY-2189265) is a novel, long-acting glucagon-like peptide 1 (GLP-1) analog being developed by Eli Lilly for the treatment of type 2 diabetes mellitus (T2DM). Dulaglutide consists of GLP-1(7-37) covalently linked to an Fc fragment of human IgG4, thereby protecting the GLP-1 moiety from inactivation by dipeptidyl peptidase 4. In vitro and in vivo studies on T2DM models demonstrated glucose-dependent insulin secretion stimulation. Pharmacokinetic studies demonstrated a t1/2 in humans of up to 90 h, making dulaglutide an ideal candidate for once-weekly dosing. Clinical trials suggest that dulaglutide reduces plasma glucose, and has an insulinotropic effect increasing insulin and C-peptide levels. Two phase II clinical trials demonstrated a dose-dependent reduction in glycated hemoglobin (HbA1c) of up to 1.52% compared with placebo. Side effects associated with dulaglutide administration were mainly gastrointestinal. To date, there have been no reports on the formation of antibodies against dulaglutide, but, clearly, long-term data will be needed to asses this and other possible side effects. The results of several phase III clinical trials are awaited for clarification of the expected effects on HbA1c and body weight. If dulaglutide possesses similar efficacy to other GLP-1 analogs, the once-weekly treatment will most likely be welcomed by patients with T2DM.
A histogram-based method for detection of faces and cars (2002)

We describe a statistical method for 3D object detection. We represent the statistics of both object appearance and non-object appearance using a product of histograms. Each histogram represents the joint statistics of a subset of wavelet coefficients and their position on the object. Our approach is to use many such histograms representing a wide variety of visual attributes. Using this method, we have developed the first algorithm that can reliably detect human faces that vary from frontal view to full profile view and the first algorithm that can reliably detect cars over a wide range of viewpoints.