gebhart/patrepeval huggingface dataset:
Minimal Cost Planning of DVB-H Networks on Existing Wireless Infrastructure (2006)

This paper addresses the problem of efficient planning DVB-H networks assuming that the existing broadcasting and cellular infrastructure can be used in the network deployment. The planning objective consists in deciding which existing cellular sites should be used jointly with the broadcasting towers in a minimum cost deployment. A multi-objective genetic algorithm has been utilized to seek minimum cost network configurations as a function of the area coverage level. We investigate the achievable cost savings offered by a hybrid infrastructure compared to using only the existing broadcasting towers and the cellular sites separately
Damping characteristics of a composite-reinforced stainless-steel plate (1987)

The investigation of damping characteristics of composite-steel laminates was initiated for the Naval Underwater Systems in March 1987. Phase 2 of the Composite Damping Task consists of fabricating a composite laminated stainless-steel plate and comparing the damping characteristics to that of a ''bare'' stainless-steel plate. This report summarizes the activities initiated under Phase II of this project performed at the Enrichment Technology Applications Center, Martin Marietta Energy Systems, Inc.
Search forWbb¯andWHProduction inpp¯Collisions ats=1.96  TeV (2005)

We present a search for Wbb production in pp collisions at sqrt[s]=1.96 TeV in events containing one electron, an imbalance in transverse momentum, and two b-tagged jets. Using 174 pb(-1) of integrated luminosity accumulated by the D0 experiment at the Fermilab Tevatron collider, and the standard-model description of such events, we set a 95% C.L. upper limit on Wbb production of 6.6 pb for b quarks with transverse momenta p(b)(T)>20 GeV and bb separation in pseudorapidity-azimuth space DeltaR(bb)>0.75. Restricting the search to optimized bb mass intervals provides upper limits on WH production of 9.0-12.2 pb for Higgs-boson masses of 105-135 GeV.
Equalization and near-end crosstalk (NEXT) noise cancellation for 20-Gb/s 4-PAM backplane serial I/O interconnections (2005)

Limitations in current backplane environments impede high-speed data transmission above 5 Gb/s. A system architecture to extend the transmission capacities of legacy backplanes is proposed. The incentives for using a four-level pulse amplitude modulation (4-PAM) scheme are also presented. The architecture is built from feed-forward equalizer and tunable filter elements for near-end crosstalk noise cancellation. Each of the circuits is implemented in a standard 0.18-/spl mu/m CMOS process. The building blocks of the architecture, which include an LC ladder, a modified Gilbert-cell multiplier with improved headroom, and a tunable active high-pass filter are described in detail. Results of the architecture are shown demonstrating 20-Gb/s 4-PAM signal transmission.
Comparative pharmacokinetic and tolerability evaluation of two simvastatin 20 mg formulations in healthy Korean male volunteers (2017)

Simvastatin is used to reduce plasma cholesterol by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and is primarily used to treat hypercholesterolemia. This study was conducted to assess the bioequivalence between the generic formulation of simvastatin 20 mg and the branded formulation of simvastatin 20 mg. A generic formulation of simvastatin 20 mg tablet was developed and the pharmacokinetics of the generic formulation were compared with those of the branded formulation of simvastatin 20 mg tablet in 33 healthy male volunteers after a single oral dose in a randomized, open-label, two-period, two-sequence, crossover study. The reference (Zocor®, MSD Korea LTD.) and test (Simvarotin®, Korea Arlico Pharm Co., Ltd.) formulations, two 20 mg tablets each, were administered to all subjects in fasting status. The serial blood samples for pharmacokinetic analysis were collected before dosing and up to 24 hours post-dose, and plasma concentrations of simvastatin were determined by liquid chromatography-tandem mass spectrometry. The pharmacokinetic parameters including T<sub>max</sub>, C<sub>max</sub>, AUC<sub>last</sub>, AUC<sub>inf</sub> and t<sub>½</sub> were calculated for both formulations by non-compartmental method, and the log-transformed C<sub>max</sub> and AUC<sub>last</sub> were compared statistically. Geometric mean ratios (90% confidence intervals) of the test to the reference formulation in C<sub>max</sub> and AUC<sub>last</sub> were 0.9652 (0.8302-1.1223) and 0.9891 (0.8541-1.1455), respectively. No significant differences in tolerability profiles were noted between the two formulations. The two formulations of simvastatin 20 mg tablets exhibited comparable pharmacokinetic profiles and 90% confidence intervals were within the acceptable range of bioequivalence criteria.
Un algorithme ICM basé sur la compacité pour la segmentation des images satellites à très haute résolution (2015)

Dans cet article nous proposons une modification pour l’algorithme "Iterated Conditional Modes" (ICM) appliqué à la segmentation d’images à très haute résolution. Pour ce faire, nous introduisons un nouveau critère de convergence basé sur la compacité des clusters et qui repose sur une fonction d’énergie adaptée aux modèles de voisinages irréguliers de ce type d’images. Grâce à cette méthode, nos premières expériences ont montré que nous obtenons des résultats plus fiables en terme de convergence et de meilleure qualité qu’en utilisant l’énergie globale comme critère d’arrêt .
Id2 leaves the chromatin of the E2F4–p130-controlled c-myc promoter during hepatocyte priming for liver regeneration (2006)

The Id (inhibitor of DNA binding or inhibitor of differentiation) helix-loop-helix proteins are involved in the regulation of cell growth, differentiation and cancer. The fact that the molecular mechanisms of liver regeneration are not completely understood prompted us to study the fate of Id2 in proliferating liver. Id2 increases in liver regeneration after partial hepatectomy, following the early induction of its gene. Co-immunoprecipitation shows that Id2 forms a complex with E2F4, p130 and mSin3A in quiescent liver and all these components are present at the c-myc promoter as shown using ChIP (chromatin immunoprecipitation). Activation of c-myc during hepatocyte priming (G0-G1 transition) correlates with the dissociation of Id2 and HDAC (histone deacetylase), albeit p130 remains bound at least until 6 h. Moreover, as the G0-G1 transition progresses, Id2 and HDAC again bind the c-myc promoter concomitantly with the repression of this gene. The time course of c-myc binding to the Id2 promoter, as determined by ChIP assays is compatible with a role of the oncoprotein as a transcriptional inducer of Id2 in liver regeneration. Immunohistochemical analysis shows that Id2 also increases in proliferating hepatocytes after bile duct ligation. In this case, the pattern of Id2 presence in the c-myc promoter parallels that found in regenerating liver. Our results may suggest a control role for Id2 in hepatocyte priming, through a p130 dissociation-independent regulation of c-myc.
In vivo therapy of a murine B cell tumor (BCL1) using antibody-ricin A chain immunotoxins. (1982)

Prolonged remissions were induced in mice bearing advanced BCL1 tumors by the combined approach of nonspecific cytoreductive therapy and administration of a tumor-reactive immunotoxin. Thus, the vast majority of the tumor cells (approximately 95%) were first killed by nonspecific cytoreductive therapy using total lymphoid irradiation (TLI) and splenectomy. The residual tumor cells were then eliminated by intravenous administration of an anti-delta immunotoxin. In three of four experiments, all animals treated in the above fashion appeared tumor free 12-16 wk later. In one experiment, blood cells from the mice in remission were transferred to normal BALB/c recipients, and the latter animals have not developed detectable tumor for the 6 mo of observation. Because 1-10 adoptively transferred BCL1 cells will cause tumor in normal BALB/c mice by 12 wk, the inability to transfer tumor to recipients might indicate that the donor animals were tumor free. In the remainder of the animals treated with the tumor-reactive immunotoxin there was a substantial remission in all animals, but the disease eventually reappeared. In contrast, all mice treated with the control immunotoxin or antibody alone relapsed significantly earlier (3-4 wk after splenectomy).
Hypothyroidism and related comorbidities on the risks of developing tinnitus (2022)

This is a retrospective longitudinal study that uses data from the National Health Insurance Research Database (NHIRD) of Taiwan of which hypothyroid patients who received a diagnosis between 2000 and 2010 were selected and followed up until 2011. The primary outcome of this study was the occurrence of tinnitus (ICD-9-CM code 388.3). The relevant comorbidities were selected as potential confounders according to the literature, which included vertigo (ICD-9-CM code 386), insomnia (ICD-9-CM code 780), anxiety (ICD-9-CM code 300.00), and hearing loss (ICD-9-CM code 388-389). The overall incidence of tinnitus was significantly higher in the hypothyroidism cohort than in the non-hypothyroidism cohort (9.49 vs. 6.03 per 1000 person-years), with an adjusted HR of 1.35 (95% CI 1.18-1.54) after adjusting potential confounders. The incidences of tinnitus, as stratified by gender, age, comorbidity, and follow-up time, were all significantly higher in the hypothyroidism cohort than those in the non-hypothyroidism cohort. The incidence of tinnitus significantly increased with age (aHR = 1.01, 95% CI 1.01-1.02). In conclusion, we report the relationship between hypothyroidism and the increased risk for tinnitus. We also found that hypothyroidism patients are at increased risk of developing tinnitus when associated with comorbidities including vertigo, hearing loss, and insomnia.
Entomological evaluation by pool screen polymerase chain reaction of Onchocerca volvulus transmission in Ecuador following mass Mectizan distribution. (2003)

The prevalence of infected and infective black flies was estimated by pool screen polymerase chain reaction (PCR) amplification in the three river basins in Ecuador endemic for onchocerciasis. Mass distribution of ivermectin (Mectizan) resulted in dramatic declines in the prevalence of infected and infective flies. In the Rio Santiago river basin, no infections were detected, suggesting that transmission had ceased. The ratio of infected to infective flies in Simulium exiguum was 10-fold lower than the corresponding ratio for Simulium quadrivittatum, suggesting that S. exiguum is a more-competent vector for Onchocerca volvulus than S. quadrivittatum. However, the prevalence of infective flies in the two species was not different, suggesting that S. quadrivittatum may play an important vectorial role where it is the dominant human-biting species. The data demonstrate that pool screen PCR is an efficient way to monitor transmission in areas subject to control, and to certify an area as free of O. volvulus transmission.
Tunable Synthesis of Mesoporous Silica Particles with Unique Radially Oriented Pore Structures from Tetramethyl Orthosilicate via Oil–Water Emulsion Process (2016)

Numerous studies of the synthesis of mesoporous silica (MPS) particles with tailored properties have been published. Among those studies, tetraethyl orthosilicate (TEOS) is commonly used as a silica source, but tetramethyl orthosilicate (TMOS) is rarely used because its reaction is fast and difficult to control. In this study, MPS particles were synthesized via one-step controlled polymerization of styrene and hydrolysis of TMOS, followed by the addition of hexadecyltrimethylammonium bromide (CTAB) and n-octane. The MPS particles obtained from TMOS generally have small inner pores, but the MPS particles obtained in this study had a unique radially oriented structure, a high surface area up to 800 m2 g–1, and large pores, of size 20 nm. The content of styrene in the emulsion system played a key role in increasing pore sizes of the MPS particles. A plausible mechanism for particle formation based on the phase behavior and type of the emulsion system is proposed. For further research, this material is expected to be useful for various applications, such as in drug delivery, filtration, and catalyst supports.
Pharmacokinetics of levosimendan in pediatric patients evaluated for cardiac surgery (2004)

The pharmacokinetic profile of levosimendan in children with congenital heart disease is similar to that in adult patients with congestive heart failure. The minimal hemodynamic efficacy after the 12 microg/kg levosimendan bolus was probably due to a small dose relative to body surface area.
Multislice ex vivo thermoacoustic imaging of porcine kidneys (2011)

We have added multi-slice acquisition capability to our thermoacoustic testbed. Thermoacoustic signal is generated because test specimens selectively absorb pulsed electromagnetic energy producing rapid thermal expansions that generate ultrasonic pulses. Filtered back-projection reconstruction yields images over an 8 cm field of view. Preliminary reconstructions of porcine kidneys track slice-to-slice progression of calyces, although renal pyramids are not well visualized.
Excited state lifetime and intersystem crossing rate of asymmetric pentaazadentate porphyrin-like metal complexes (2004)

The first singlet excited state lifetimes (τs) of asymmetric pentaazadentate porphyrin-like complexes, [(R-APPC)M]Cln, were measured by the time-correlated single photon counting method. Fluorescent decays of the first singlet excited state for all [(R-APPC)M]Cln were found to be shorter than 0.5ns. The intersystem crossing rates (kisc) were calculated from the τs values and previously measured triplet quantum yields (ϕT). Values for kisc for the complexes ranged from 0.68 to 3.04×109s−1 and are significantly greater than those of silicon naphthalocyanine (SiNc) and lead phthalocyanine (PbPc(CP)4). The values of τs and kisc of the [(R-APPC)M]Cln complexes are sensitive to variations in both the bridging R group and the metal center.
Space-Time Decision-Directed Equalizer for SIMO Systems based on Affine Projection Algorithm (2006)

This paper introduces a space-time decision feedback equalizer whose coefficients are recursively renewed on the basis of the modified affine projection algorithm (APA). Despite its effectiveness against the rank deficiency problem, the complexity of the conventional APA utilizing the sample matrix inversion (SMI) is considerable. Furthermore, the shift invariance property could not be exploited in the case of the space-time decision directed equalizer (STDE) application. To overcome such challenges, this paper introduces an APA employing hyperplane projection scheme reducing the computational complexity without any degradation of convergence characteristic and tracking capability. The performance of the proposed equalization methodology is verified by showing its superior bit error rate (BER) behaviors via performing adaptive STDE under single-input-multiple-output (SIMO) wireless multipath fading channel
Antigenicity and immunogenicity of recombinant glutamate-rich protein of Plasmodium falciparum expressed in Escherichia coli (1995)

A recombinant Plasmodium falciparum glutamate-rich protein (GLURP) was produced in Escherichia coli as a nearly full-length protein. In order to map immunodominant regions on GLURP, the nonrepetitive amino-terminal region (R0) as well as the central repeat region (R1) and the carboxy-terminal repeat region (R2) were also produced as separate products. All four purified gene products reacted specifically with serum samples from adults living in an area of Liberia where malaria is holoendemic. It appears that the human immune response against GLURP is primarily directed against the R2 region because 94% of the serum samples reacted with this region in an immunoassay. Antibody reactivity against the R0 region was also observed in 75% of the serum samples, while the R1 region showed only weak antibody-binding activity. When the nearly full-length GLURP molecule was adsorbed to Al(OH)3 it was found to be immunogenic in mice. In these experiments, the antibody response was almost exclusively directed against the R2 region. When anti-GLURP sera were obtained from rabbits immunized with the three regions, R0, R1, and R2, respectively, they recognized in immunoprecipitation experiments authentic GLURP from P. falciparum grown in vitro. These results demonstrate that GLURP produced in E. coli can induce a humoral immune response against GLURP derived from blood-stage parasites.
Determining the Syringyl/Guaiacyl Lignin Ratio in the Vessel and Fiber Cell Walls of Transgenic Populus Plants (2016)

Observation of the spatial lignin distribution throughout the plant cell wall provides insight into the physicochemical characteristics of lignocellulosic biomass. The distribution of syringyl (S) and guaiacyl (G) lignin in cell walls of a genetically modified Populus deltoides and its corresponding empty vector control were analyzed with time-of-flight secondary ion mass spectrometry (ToF-SIMS) and then mapped to determine the S/G lignin ratio of the sample surface and specific regions of interest (ROIs). The surface characterizations of transgenic cross-sections within 1 cm vertical distance of each other on the stem possess similar S/G lignin ratios. The analysis of the ROIs determined that there was a 50% decrease in the S/G lignin ratio of the transgenic xylem fiber cell walls.
Emotional and behavioural problems in subgroups of children with chronic illness: results from a large‐scale population study (2009)

The increased rate of emotional and behavioural problems in children with chronic illness, especially neurological disorders, emphasizes the importance of early detection of mental health problems in these children.
Modelling of Two-component Yarns Part I: The Compressibility of Yarns (1997)

AbstractThis paper considers the compression properties of yarns. A model is proposed which predicts the behaviour of yarns in compression; the model takes account of the structural characteristics of yarns and the finite dimensions of fibres. A device is described which has been successfully used to measure the effects of compression forces on the dimensions of yarn cross-sections.A comparison between the theoretical behaviour of yarns and experimental results demonstrates the good predictive ability of the theory.
What caused the outbreak of ESBL-producing Klebsiella pneumoniae in a neonatal intensive care unit, Germany 2009 to 2012? Reconstructing transmission with epidemiological analysis and whole-genome sequencing (2015)

Epidemiological and phylogenetic analyses consistently indicated that there were additional, undiscovered cases prior to the onset of microbiological screening and that the spread of the pathogen remained undetected over several years, driven predominantly by person-to-person transmission. Whole-genome sequencing provided valuable information on the onset, course and size of the outbreak, and on possible ways of transmission.
Homodecoupled 1,1‐ and 1,n‐ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine (2015)

Abstract Cryptospirolepine is the most structurally complex alkaloid discovered and characterized thus far from any Cryptolepis specie. Characterization of several degradants of the original, sealed NMR sample a decade after the initial report called the validity of the originally proposed structure in question. We now report the development of improved, homodecoupled variants of the 1,1‐ and 1,n‐ADEQUATE (HD‐ADEQUATE) NMR experiments; utilization of these techniques was critical to successfully resolving long‐standing structural questions associated with crytospirolepine.
Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1–ADIPOQ (2010)

Adiponectin is an adipocyte-secreted protein involved in a variety of metabolic processes, including glucose regulation and fatty acid catabolism. We conducted a genome-wide association study to investigate the genetic loci associated with plasma adiponectin in 1776 unrelated Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS). Our strongest signal for adiponectin mapped to the gene CDH13 (rs3865188, P ≤ 7.2 × 10(-16)), which encodes a receptor for high-molecular-weight forms of adiponectin. Strong association was also detected near the ADIPOQ gene (rs864265, P = 3.8 × 10(-9)) and at a novel signal 100 kb upstream near KNG1 (rs11924390, P = 7.6 × 10(-7)). All three signals were also observed in 1774 young adult CLHNS offspring and in combined analysis including all 3550 mothers and offspring samples (all P ≤ 1.6 × 10(-9)). An uncommon haplotype of rs11924390 and rs864265 (haplotype frequency = 0.050) was strongly associated with lower adiponectin compared with the most common C-G haplotype in both CLHNS mothers (P = 1.8 × 10(-25)) and offspring (P = 8.7 × 10(-32)). Comprehensive imputation of 2653 SNPs in a 2 Mb region using as reference combined CHB, JPT and CEU haplotypes from the 1000 Genomes Project revealed no variants that perfectly tagged this haplotype. Our findings provide the first genome-wide significant evidence of association with plasma adiponectin at the CDH13 locus and identify a novel uncommon KNG1-ADIPOQ haplotype strongly associated with adiponectin levels in Filipinos.
Recyclage des matériaux composites: Etat de l'art et perspectives (2015)

National audience
A z‐gradient array for simultaneous multi‐slice excitation with a single‐band RF pulse (2017)

The possibility of multi-slice excitation with a single-band RF pulse using a z-gradient array is validated in simulations and phantom experiments. Magn Reson Med 80:400-412, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Effect of Season, Walking Surface and Sire Identification on Thin Soles in Dairy Cattle (2007)

Thin soles have become a major economic problem in large total confinement dairies in the United States. The cause appears to be multifactorial and relates to factors that result in an increase in sole horn wear. Factors such as the distance cows have to walk on concrete to be milked, poor cow comfort, claw horn moisture content and horn quality, heat stress and overtrimming have been implicated. The purpose of this study was to: a) investigate the incidence of thin soles over a period of 12 months from two herds in relation to month of year b) determine the incidence of thin soles in first lactation cows in Herd 1 for the 9 months prior and 9 months following installation of rubber on walk ways and c) determine any sire effect on thin soles for first lactation cows in Herd 1.
Do family physicians make good sentinels for influenza? (1993)

Family physicians provide sensitive, timely, and accurate community influenza morbidity data that complement data from other surveillance systems. This information enables monitoring of the type, timing, and intensity of influenza activity and can help health care workers implement prevention or control measures.
Automatic speech emotion recognition using recurrent neural networks with local attention (2017)

Automatic emotion recognition from speech is a challenging task which relies heavily on the effectiveness of the speech features used for classification. In this work, we study the use of deep learning to automatically discover emotionally relevant features from speech. It is shown that using a deep recurrent neural network, we can learn both the short-time frame-level acoustic features that are emotionally relevant, as well as an appropriate temporal aggregation of those features into a compact utterance-level representation. Moreover, we propose a novel strategy for feature pooling over time which uses local attention in order to focus on specific regions of a speech signal that are more emotionally salient. The proposed solution is evaluated on the IEMOCAP corpus, and is shown to provide more accurate predictions compared to existing emotion recognition algorithms.