gebhart/patrepeval huggingface dataset:
Preparation of bis(trimethylsilyl)aminochlorodimethylaminoborane (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of bis(trimethylsilyl)aminochlorodimethylaminoboraneRichard L. Wells and Harvey L. PaigeCite this: Inorg. Chem. 1971, 10, 7, 1526–1528Publication Date (Print):July 1, 1971Publication History Published online1 May 2002Published inissue 1 July 1971https://pubs.acs.org/doi/10.1021/ic50101a044https://doi.org/10.1021/ic50101a044research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Differential Gene Expression Associated with Soybean Oil Level in the Diet of Pigs (2022)

The aim of this study was to identify the differentially expressed genes (DEG) from the skeletal muscle and liver samples of animal model for metabolic diseases in human. To perform the study, the fatty acid (FA) profile and RNA sequencing (RNA-Seq) data of 35 samples of liver tissue (SOY1.5, n=17 and SOY3.0, n=18) and 36 samples of skeletal muscle (SOY1.5, n=18 and SOY3.0, n=18) of Large White pigs were analyzed. The FA profile of the tissues was modified by the diet, mainly those related to monounsaturated (MUFA) and polyunsaturated (PUFA) FA. The skeletal muscle transcriptome analysis revealed 45 DEG (FDR 10%), and the functional enrichment analysis identified network maps related to inflammation, immune process, and pathways associated with the oxidative stress, type 2 diabetes and metabolic dysfunction. For the liver tissue, the transcriptome profile analysis revealed 281 DEG, which participate in network maps related to neurodegenerative diseases. With this nutrigenomics study, we verified that different levels of soybean oil in the pig diet, an animal model for metabolic diseases in humans, affected the transcriptome profile of skeletal muscle and liver tissue. These findings may help to better understand the biological mechanisms that can be modulated by the diet.
START: A phase III study of L-BLP25 cancer immunotherapy for unresectable stage III non-small cell lung cancer. (2013)

7500 Background: L-BLP25 is a MUC1 antigen specific cancer immunotherapy. We report results from the phase III START study of L-BLP25 in patients (pts) not progressing after primary chemoradiotherapy (CRT) for stage III NSCLC. Methods: From Jan 2007 to Nov 2011, 1513 pts with unresectable stage III NSCLC that did not progress after CRT (platinum based chemo and ≥50 Gy) were randomized (2:1; double-blind) to L-BLP25 (806 µg lipopeptide) or placebo (PBO) SC weekly x 8 then Q6 weeks until disease progression or withdrawal. Cyclophosphamide 300 mg/m 2 x 1 or saline was given 3 days prior to first L-BLP25/PBO dose. Primary endpoint was overall survival (OS). Results: The primary analysis population (n=1239) was defined prospectively to try to account for a clinical hold by excluding pts randomized 6 months (m) before the hold. Arms were balanced for baseline characteristics. Median age was 61 y; 38.2% had stage IIIA and 61.3% IIIB; 65% had concurrent and 35% sequential CRT. Median OS was 25.6 m with L-BLP25 vs. 22.3 m with PBO (adjusted HR 0.88, 95% CI 0.75-1.03, p=0.123). Secondary endpoints time-to-progression and time-to-symptom-progression support consistency of results: HR 0.87 (95% CI 0.75-1.00, p=0.053) and 0.85 (95% CI 0.73-0.98, p=0.023). In predefined subgroup analyses, pts with concurrent CRT (n=806) had median OS of 30.8 m (L-BLP25) vs. 20.6 m (PBO; HR 0.78, 95% CI 0.64-0.95, p=0.016), while median OS with sequential CRT was 19.4 m (L-BLP25) vs. 24.6 m (PBO; HR 1.12, 95% CI 0.87-1.44, p=0.38; interaction p=0.032, Cox PH model). Sensitivity analyses revealed that there was no OS benefit in pts randomized 6 m before the hold (HR 1.09, CI 0.75-1.56, p=0.663). LEBLP25 was well tolerated with no safety concerns identified and no emergent evidence of immune related adverse events. Conclusions: L-BLP25 maintenance therapy in stage III NSCLC was well tolerated, but did not significantly prolong OS. Sensitivity analyses showed a smaller treatment effect due to the clinical hold, suggesting that longer uninterrupted treatment with L-BLP25 is required. Clinically meaningful prolongation of OS was observed in the predefined subgroup of pts with primary concurrent CRT. Clinical trial information: NCT00409188.
Enhanced Gilbert Damping in Thin Ferromagnetic Films (2002)

The precession of the magnetization of a ferromagnet is shown to transfer spins into adjacent normal metal layers. This "pumping" of spins slows down the precession corresponding to an enhanced Gilbert damping constant in the Landau-Lifshitz equation. The damping is expressed in terms of the scattering matrix of the ferromagnetic layer, which is accessible to model and first-principles calculations. Our estimates for permalloy thin films explain the trends observed in recent experiments.
Quantitative determination of water sorption by plant cuticles (1991)

Abstract. The water sorption by cuticular membranes (CM) isolated from both leaves and fruit and representing different structural and chemical cuticular types, was measured over the whole range of relative humidities using a magnetic suspension microbalance. The sorption isotherms were generally not linear and sorption increased more rapidly at the highest values of relative humidity. The highest values of water content, at 80–99% r.h., measured for the seven species ranged from 1.1 to 7.7% of the dehydrated weight. Extraction of the soluble cuticular lipids did not result in a decrease of sorption, but only in a lower interspecific dispersion. There was a drastic reduction (63%) in water sorption when polymer matrix membranes (MX) were partially acid‐hydrolysed; but methylation or charging with iron of (MX) did not have any significant effect on water sorption. The data obtained are discussed in relation to cuticular permeability. Two determinants of water permeability were determined: the partition coefficient (K) relating the equilibrium Water concentration of the cuticle to that of the surrounding atmosphere; and the diffusion coefficient (D), calculated from the half‐times of the sorption process in kinetic measurements.
Anxiety, depression, and nature of acne vulgaris in adolescents (2000)

Acne results in higher anxiety in adolescent girls. Although acne and moderate/severe acne are more common in adolescent boys, the severity of acne was found to be similar in boys and girls with acne. Adolescent girls are more vulnerable than boys to the negative psychological effects of acne.
Thermal and electrical properties of glass fiber reinforced o‐cresol novolac epoxy composites cured with allylated phenol novolac hardener (2012)

Abstract An allyl group was introduced into a phenol novolac hardener to improve the thermal and electrical properties of glass fiber reinforced o ‐cresol novolac epoxy composites. Based on 1 H NMR analysis, it was found that the degree of allylation was measured as 12.5% and 15.3% of allylated moieties underwent Claisen rearrangement. Thermal and electrical properties of the prepared composites were investigated by thermal mechanical analysis, dynamic mechanical analysis and dielectric measurements. Their thermal expansion coefficient and glass transition temperature measured by thermal mechanical analysis varied from 20.1 to 18.0 ppm K −1 and 132.5 to 170.9 °C, respectively, due to allylation of the phenol novolac hardener. From the storage modulus at the rubbery plateau, it was confirmed that these improvements were mainly caused by an increase in the crosslink density of the matrix resin owing to allyl groups. The electrical properties of the composites, however, showed no noticeable changes by allylation of the phenol novolac hardener. Copyright © 2012 Society of Chemical Industry
Adenylyl Cyclase Activation Modulates Activity-Dependent Changes in Synaptic Strength and Ca2+/Calmodulin-Dependent Kinase II Autophosphorylation (1999)

Activation of the Ca2+- and calmodulin-dependent protein kinase II (CaMKII) and its conversion into a persistently activated form by autophosphorylation are thought to be crucial events underlying the induction of long-term potentiation (LTP) by increases in postsynaptic Ca2+. Because increases in Ca2+ can also activate protein phosphatases that oppose persistent CaMKII activation, LTP induction may also require activation of signaling pathways that suppress protein phosphatase activation. Because the adenylyl cyclase (AC)-protein kinase A signaling pathway may provide a mechanism for suppressing protein phosphatase activation, we investigated the effects of AC activators on activity-dependent changes in synaptic strength and on levels of autophosphorylated alphaCaMKII (Thr286). In the CA1 region of hippocampal slices, briefly elevating extracellular Ca2+ induced an activity-dependent, transient potentiation of synaptic transmission that could be converted into a persistent potentiation by the addition of phosphatase inhibitors or AC activators. To examine activity-dependent changes in alphaCaMKII autophosphorylation, we replaced electrical presynaptic fiber stimulation with an increase in extracellular K+ to achieve a more global synaptic activation during perfusion of high Ca2+ solutions. In the presence of the AC activator forskolin or the protein phosphatase inhibitor calyculin A, this treatment induced a LTP-like synaptic potentiation and a persistent increase in autophosphorylated alphaCaMKII levels. In the absence of forskolin or calyculin A, it had no lasting effect on synaptic strength and induced a persistent decrease in autophosphorylated alphaCaMKII levels. Our results suggest that AC activation facilitates LTP induction by suppressing protein phosphatases and enabling a persistent increase in the levels of autophosphorylated CaMKII.
Amide Synthesis from Alcohols and Amines by the Extrusion of Dihydrogen (2008)

An environmentally friendly method for synthesis of amides is presented where a simple ruthenium catalyst mediates the direct coupling between an alcohol and an amine with the liberation of two molecules of dihydrogen. The active catalyst is generated in situ from an easily available ruthenium complex, an N-heterocyclic carbene and a phosphine. The reaction allows primary alcohols to be coupled with primary alkylamines to afford the corresponding secondary amides in good yields. The amide formation presumably proceeds through a catalytic cycle where the intermediate aldehyde and hemiaminal are both coordinated to the metal catalyst.
Biological activity of angiotensin-(1-7) heptapeptide in the hamster heart. (1990)

Angiotensin II has been reported to have both a positive inotropic effect and a coronary constrictor action in the hamster heart. To study the contribution to these responses of phenylalanine in position 8, we assessed the direct cardiac effects of angiotensin-(1-7), which lacks phenylalanine in position 8. Syrian hamsters were used to determine the effects of angiotensin-(1-7) on cardiac performance in the diseased and normal hearts. We used the isolated isovolumic heart preparation perfused either at a constant pressure of 50 mm Hg or at a constant coronary (myocardial) flow rate of 7 ml/min (seven cardiomyopathic hamsters [CMH] and seven normal hamsters [NH] in each subgroup). At constant perfusion pressure, coronary (myocardial) flow rate decreased (p less than 0.01) in both CMH and NH (-31 +/- 8% vs. -39 +/- 4% of baseline, respectively); but the percent decrease in left ventricular pressure and the first derivative of left ventricular pressure over time (LV + dP/dt) was significant only in NH (-8 +/- 1% and -9 +/- 4%) but not in CMH (-14 +/- 5% and -21 +/- 8%). On the other hand, at a constant coronary (myocardial) flow rate, left ventricular pressure and LV + dP/dt tended to increase in both CMH and NH (+10 +/- 3% and +6 +/- 2% of baseline vs. +7 +/- 7% and +7 +/- 5%, respectively) but these changes were not significant.(ABSTRACT TRUNCATED AT 250 WORDS)
Defect learning methodology applied to microbump process at 20μm pitch and below (2018)

Over the last years, 3D TSV technology and 3D stacking have moved into the preproduction and yield ramp phase. The characterization of many of the different critical modules within the 3D stacking integration flows is becoming more and more crucial. Microbump dimensions are being scaled down to the pitch of 20μm and below. This scaling is required in order to achieve higher interconnect densities. For yielding vertical interconnects in die-to-die and die-to-wafer stacking, highly accurate and repeatable measurements and inspections of microbumps are an absolute must for this technology to become a viable industrial option. Microbump process control is usually a hybrid approach of inspecting the full wafer including all microbumps and specific microbump metrology. This eventually enables correct die classification and selection of known good die for further integration in 3D packages. Prior to being able to classify and disposition die based on microbump integrity, yield critical defect types need to be identified, defect mechanisms need to be understood and dimensional features impacting further processing need to be characterized. This paper addresses these requirements and elaborates on the applied defect learning methodology based on a significant amount of microbump process monitor wafers. Yield loss by every defect type was quantified and root causes for these yield critical defect types were discovered. From this analysis, further process improvement projects can be initiated, parameters for statistical process control derived and known good die for yielding die-to-die and die-to-wafer stacking can be identified and separated from failing die.
Search for Boosted Dark Matter Interacting with Electrons in Super-Kamiokande (2018)

A search for boosted dark matter using 161.9 kt yr of Super-Kamiokande IV data is presented. We search for an excess of elastically scattered electrons above the atmospheric neutrino background, with a visible energy between 100 MeV and 1 TeV, pointing back to the Galactic center or the Sun. No such excess is observed. Limits on boosted dark matter event rates in multiple angular cones around the Galactic center and Sun are calculated. Limits are also calculated for a baseline model of boosted dark matter produced from cold dark matter annihilation or decay. This is the first experimental search for boosted dark matter from the Galactic center or the Sun interacting in a terrestrial detector.
Quantification of dandruff adherence to hair (2005)

Dandruff adherence to hair shafts is a visible annoying phenomenon. The aspect can be recorded by different means including the ultraviolet light-enhanced visualization (ULEV) method and microscopy. We present another quantitative method. Hairs were clipped from the parietal scalp area of 25 volunteers complaining of dandruff. They were firmly applied onto cyanoacrylate-coated microscopic slides. Hairs were lifted up after 15-20 s leaving a cast in the adhesive coat. Dandruff were thus harvested from the hair shafts and remained attached to the cyanoacrylate coat. After staining, the material was submitted to image analysis to derive the dandruff density per unit length of hairs. In 11/25 subjects, a correlation was found between the width of the hair casts and the dandruff density. This method does not collect all dandruff along hair shafts, but data are likely representative of the whole corneocyte load.
Obesity Affects the Liver – The Link between Adipocytes and Hepatocytes (2010)

The incidence of obesity has dramatically increased in recent years. Consequently, obesity and associated disorders such as nonalcoholic fatty liver disease (NAFLD) constitute a serious threat. Therefore, the contribution of visceral adipose tissue to metabolic homeostasis has become a focus of interest. Visceral adipose tissue secretes free fatty acids (FFAs) and hormones, known as adipokines, and thus seems to play a major role in the development of NAFLD. Apoptotic cell death is a prominent feature in nonalcoholic steatohepatitis (NASH). Indeed, toxic FFAs can activate the intrinsic apoptosis pathway in hepatocytes via c-Jun N-terminal kinase (JNK). JNK activates the proapoptotic protein Bim, resulting in Bax activation and enhanced apoptosis, termed 'lipoapoptosis'. Reduced adiponectin levels may establish a proinflammatory milieu, thus increasing vulnerability to lipotoxicity, which promotes progression from simple steatosis to NASH and even advanced hepatic fibrosis. Moreover, obesity seems to be a risk factor for hepatocellular carcinoma, the most frequent liver cancer subtype. Even in acute liver failure, a high body mass index is associated with poor outcome, and recent data suggest a major role of obesity in the progression of chronic hepatitis C and B. This review summarizes current knowledge - highlighting the inflammatory and cytokine view - of the intimate relationship between adipose and liver tissue.
Identification and Mitigation of Conducting Package Losses for Quantum Superconducting Devices (2023)

Low-loss superconducting rf devices are required when used for quantum computation. Here, we present a series of measurements and simulations showing that conducting losses in the packaging of our superconducting resonator devices affect the maximum achievable internal quality factors (Qi) for a series of thin-film Al quarter-wave resonators with fundamental resonant frequencies varying between 4.9 and 5.8 GHz. By utilizing resonators with different widths and gaps, different volumes of the stored electromagnetic energy were sampled thus affecting Qi. When the backside of the sapphire substrate of the resonator device is adhered to a Cu package with a conducting silver glue, a monotonic decrease in the maximum achievable Qi is found as the electromagnetic sampling volume is increased. This is a result of induced currents in large surface resistance regions and dissipation underneath the substrate. By placing a hole underneath the substrate and using superconducting material for the package, we decrease the ohmic losses and increase the maximum Qi for the larger size resonators.
Otimização do processo de recuperação e concentração da bromelina utilizando membranas cerâmicas (2009)

The processes of separation for membranes present an alternative technically and economically attractive  to recover and purify proteins. These processes demand little energy, besides presenting great specificity  in separation. Bromelain is a proteolytic enzyme that has a high medicinal value. Its action includes:  inhibition of the platelet aggregation, fibrinolytic activity, anti-inflammatory, antitumoral, increased  absorption of other drugs, facilitating digestion, healing accelerator, etc.. In view of the importance of the  above-mentioned enzyme was held above the optimization of the recovery and concentration of  bromelain from pineapple (Ananas comosus) using ceramic membranes.
A New Phlebovirus Associated with Severe Febrile Illness in Missouri (2012)

Two men from northwestern Missouri independently presented to a medical facility with fever, fatigue, diarrhea, thrombocytopenia, and leukopenia, and both had been bitten by ticks 5 to 7 days before the onset of illness. Ehrlichia chaffeensis was suspected as the causal agent but was not found on serologic analysis, polymerase-chain-reaction (PCR) assay, or cell culture. Electron microscopy revealed viruses consistent with members of the Bunyaviridae family. Next-generation sequencing and phylogenetic analysis identified the viruses as novel members of the phlebovirus genus. Although Koch's postulates have not been completely fulfilled, we believe that this phlebovirus, which is novel in the Americas, is the cause of this clinical syndrome.
Intelligent Design of Automobile Fixtures with Genetic Algorithms (2007)

The design of an automobile fixture system should meet several interference-free requirements while locating fixture positions, e.g. (1) interference-free among various fixture modules, (2) interference-free among work pieces and fixture modules during clipping and moving and (3) interference-free among machining tools and fixture modules. Furthermore, a good design also needs to minimize the cost by selecting proper fixtures from the existed modular fixtures under clip-force limitations in the specification. To achieve multiple complex constraints and cost-minimum requirement, real-coded genetic algorithm (RGA) is proposed to resolve the optimum problem. Comparing to the traditional try-and-error method, the design based on this work is obviously cost-effective and time-saving by cutting down the total deign time and fixture assembling time due to the capability of finding more precise and complete solution.
Histology of Healing Split-Thickness, Full-Thickness Autogenous Skin Grafts and Donor Sites (1965)

ALTHOUGH skin grafting is an ancient art, the processes of graft healing have been carefully observed and reported only during the past 90 years. The several histologic studies, however, have suffered from a variety of defects. Most have described only a few grafts or have reported on the events of only the first few days after grafting. In 1954, Gillman et al<sup>1</sup>reported the most extensive study. Even this work, based on observations of Thiersch split-thickness grafts placed on six human volunteers and followed up as long as 80 days, had several shortcomings. Split-thickness grafts were grafted onto Thiersch donor sites, thus introducing a very artificial situation. Multiple grafts were placed on a relatively small area of the forearm; the size of the biopsy was limited, and it is probable that the biopsies influenced subsequent healing. This paper reports in detail the histologic changes which occur in donor sites