gebhart/patrepeval huggingface dataset:
wall. Ex Baker: A Source of PDE5 Inhibitors (2013)

Kaempferia parviflora Wall. ex Baker has been popularly used as male sexual performance enhancer in Thailand. However, its mechanisms were still unknown. One of the possible mechanism for this remedy is phosphodiesterase 5 (PDE5) inhibition. Among 41 plant extracts, the rhizomes of K. parviflora ethanolic extract could inhibit PDE5 at 50 g/ml. Therefore, eight 7methoxyflavones which are the major the chemical constituents isolated from rhizomes of K. parviflora were further investigated on inhibitory activity against PDE5. Moreover, the selectivity of these compounds on PDE5 over PDE6 was evaluated. The results showed that 7-methoxyflavones from this plant showed inhibition effect toward both enzymes. The most potent PDE5 inhibitor was 5,7-dimethoxyflavone (IC 50 =10.642.09 M, selectivity on PDE5 over PDE6 = 3.71). Structure activity relationship showed that the methoxyl group at C-5 position of 7-methoxyflavones was necessary for PDE5 inhibition. K. parviflora rhizome extract and its 7-methoxyflavone constituents had moderate inhibitory activity against PDE5. This finding provides an explanation for enhancing sexual performance in the traditional use of K. parviflora. Moreover, 5,7dimethoxyflavones could be a useful lead compound for clinically efficacious PDE5 inhibitors.
Metabolism of the Catharanthus Alkaloids: from Streptomyces griseus to Monoamine Oxidase B (1992)

More than three decades after their discovery and implementation in medicine, essentially nothing is known about the metabolism or the implications of metabolism in mechanism of action or toxicity of the Catharanthus alkaloids. The frustrating paucity of information about pathways of metabolism has limited a major source of structure-activity relationship information and has blocked a critical avenue necessary for the logical development of new and more useful Catharanthus alkaloids. Microbial transformations, peroxidases, copper oxidases, mouse and rat cytochrome P-450 systems, and mouse brain and bovine liver monoamine oxidase (MAO) preparations have been explored in the study of Catharanthus alkaloid metabolism. In this report, we present results which have clarified the involvement of enzymatic and chemically catalyzed one-electron oxidations that yield nitrogen-centered cation radicals, iminium, and carbinolamine intermediates, all of which explain how new carbon-carbon and carbon-oxygen bonds form, or break and rearrange. The dimeric Catharanthus alkaloids are recalcitrant to oxidations catalyzed by monoamine oxidases and to both normal and induced P-450 rat microsomal preparations. However, the Catharanthus alkaloids appear to be selective reversible inhibitors of MAO-B. Chemical and biochemical aspects of the metabolic transformations of dimeric Catharanthus alkaloids are reviewed together with the implications of our findings.
Transluminal angioplasty of the abdominal aorta. (1983)

Transluminal angioplasty of the abdominal aorta was performed in 6 women between 49 and 69 years of age with histories of cigarette smoking. Five had a relatively small aorta. This procedure is effective in treating focal aortic stenoses.
Time-Resolved Photoionization Detection of a Single Er3+ Ion in Silicon (2022)

The detection of charge trap ionization induced by resonant excitation enables spectroscopy on single Er<sup>3+</sup> ions in silicon nanotransistors. In this work, a time-resolved detection method is developed to investigate the resonant excitation and relaxation of a single Er<sup>3+</sup> ion in silicon. The time-resolved detection is based on a long-lived current signal with a tunable reset and allows the measurement under stronger and shorter resonant excitation in comparison to time-averaged detection. Specifically, the short-pulse study gives an upper bound of 23.7 μs on the decay time of the <sup>4</sup>I<sub>13/2</sub> state of the Er<sup>3+</sup> ion. The fast decay and the tunable reset allow faster repetition of the single-ion detection, which is attractive for implementing this method in large-scale quantum systems of single optical centers. The findings on the detection mechanism and dynamics also provide an important basis for applying this technique to detect other single optical centers in solids.
B-cell depletion with obinutuzumab for the treatment of proliferative lupus nephritis: a randomised, double-blind, placebo-controlled trial (2022)

NCT02550652.
DING! Dataset Ranking using Formal Descriptions (2009)

Considering that thousands if not millions of linked datasets will be published soon, we motivate in this paper the need for an efficient and effective way to rank interlinked datasets based on formal descriptions of their characteristics. We propose DING (from Dataset RankING) as a new approach to rank linked datasets using information provided by the voiD vocabulary. DING is a domain-independent link anal- ysis that measures the popularity of datasets by considering the cardinality and types of the relationships. We propose also a methodology to automatically assign weights to link types. We evaluate the proposed ranking algorithm against other well known ones, such as PageRank or HITS, using synthetic voiD descriptions. Early results show that DING performs better than the standardWeb ranking algorithms.
ChemInform Abstract: INTERACTION OF CIS PLATINUM(II) COMPOUNDS WITH POLY(L‐GLUTAMATE). A DOUBLY ANCHORED SPIN‐LABEL AND A DOUBLY ANCHORED CHROMOPHORE‐LABEL (1978)

Abstract Das freie Radikal 4‐Amino‐2,2,6,6‐tetrarnethylpiperidinyl‐1‐oxy reagiert mit K 2 PtI 4 bei anschließender Zugabe von AgNO 3 zum Komplex (I), der zur Markierung von Poly(L‐glutamat), Poly(L‐asparagat) und Poly(L‐lysin) verwendet wird.
Fatigue Model for Fiber-Reinforced Polymeric Composites (2000)

A fatigue model based on cumulative damage is developed for predicting the fatigue life of fiber-reinforced polymeric composites. This model incorporates applied maximum stress, stress amplitude, loading frequency, residual tensile modulus, and material constants as parameters. The model is verified with experimental fatigue data on a glass fiber/vinyl ester composite. While the specimens are exposed to air, freshwater, or seawater at 30°C, they are subjected to tension-tension stress at four levels of applied maximum tensile stress in each of two frequencies. Both the residual mechanical properties at specified loading cycles and the number of cycles at which the specimens fail are measured. The results show that, for the material used in this study, the loss in residual tensile strength and modulus in saltwater is approximately the same as that in freshwater and that the fatigue life in these aqueous environments is shorter than that in air. Numerical analysis is carried out to determine the material constants of the composite. The fatigue model agrees well with the experimental data. The model can be used to predict the fatigue life of the polymeric composites subjected to an applied load in different environments and to predict the residual tensile modulus after a number of cycles of service at a given load.
A General Preparation of Pyridines and Pyridones via the Annulation of Ketones and Esters (2001)

A general preparation of pyridines 4a-f from stabilized ketones 3a-c and aryl ketones 3d-f is described. The annulation of stabilized esters 3g,h gives access to the corresponding 2-pyridones 4g,h. The annulation reactions proceed in fair to excellent yields (46-87%) with vinamidinium hexafluorophosphate salts 2a-d containing electron-withdrawing groups at the beta-position. The mechanism of the reaction was investigated by NMR and proceeds through the formation of a dienaminone intermediate.
Molecular weight dependence of the heats of hydration of some oligomeric ethylene oxides and their methoxyl derivatives (1993)

Abstract The molecular weight dependence of the heat of hydration of the oligomeric ethylene oxides and their monomethoxyl and dimethoxyl derivatives has been studies using microcalorimetry. In all cases the molar heat of hydration decreased rapidly at low molecular weights reaching an asymptote at molecular weights in excess of 400. Equivalent values were obtained between oligomers and blends of the same average molecular weight. The data followed the Flory relationship relating the property of a polymer to the reciprocal of its molecular weight. However, the gradient for the oligomeric ethylene oxides was different from that of the two methoxyl derivatives suggesting a change in chain configuration. © 1993 John Wiley &amp; Sons, Inc.
Big healthcare data: preserving security and privacy (2018)

Big data has fundamentally changed the way organizations manage, analyze and leverage data in any industry. One of the most promising fields where big data can be applied to make a change is healthcare. Big healthcare data has considerable potential to improve patient outcomes, predict outbreaks of epidemics, gain valuable insights, avoid preventable diseases, reduce the cost of healthcare delivery and improve the quality of life in general. However, deciding on the allowable uses of data while preserving security and patient’s right to privacy is a difficult task. Big data, no matter how useful for the advancement of medical science and vital to the success of all healthcare organizations, can only be used if security and privacy issues are addressed. To ensure a secure and trustworthy big data environment, it is essential to identify the limitations of existing solutions and envision directions for future research. In this paper, we have surveyed the state-of-the-art security and privacy challenges in big data as applied to healthcare industry, assessed how security and privacy issues occur in case of big healthcare data and discussed ways in which they may be addressed. We mainly focused on the recently proposed methods based on anonymization and encryption, compared their strengths and limitations, and envisioned future research directions.
Experiments with the nonlinear and chaotic behaviour of the multiplicative algebraic reconstruction technique (MART) algorithm for computed tomography (2004)

Among the iterative reconstruction algorithms for tomography, the multiplicative algebraic reconstruction technique (MART) has two advantages that make it stand out from other algorithms: it confines the image (and therefore the projection data) to the convex hull of the patient, and it maximizes entropy. In this paper, we have undertaken a series of experiments to determine the importance of MART nonlinearity to image quality. Variants of MART were implemented aiming to exploit and exaggerate the nonlinear properties of the algorithm. We introduce the Power MART, Boxcar Averaging MART and Bouncing MART algorithms. Power MART is linked to the relaxation concept. Its behaviour is similar to that of the chaos of a logistic equation. There appears to be an antagonism between increasing nonlinearity and noise in the projection data. The experiments confirm our general observation that regularization as a means of solving simultaneous linear equations that are underdetermined is suboptimal: it does not necessarily select the correct image from the hyperplane of solutions, and so does not maximize the image quality:x-ray dose ratio. Our investigations prove that there is scope to optimize CT algorithms and thereby achieve greater dose reduction.
Deep Meta-Learning: Learning to Learn in the Concept Space (2018)

Few-shot learning remains challenging for meta-learning that learns a learning algorithm (meta-learner) from many related tasks. In this work, we argue that this is due to the lack of a good representation for meta-learning, and propose deep meta-learning to integrate the representation power of deep learning into meta-learning. The framework is composed of three modules, a concept generator, a meta-learner, and a concept discriminator, which are learned jointly. The concept generator, e.g. a deep residual net, extracts a representation for each instance that captures its high-level concept, on which the meta-learner performs few-shot learning, and the concept discriminator recognizes the concepts. By learning to learn in the concept space rather than in the complicated instance space, deep meta-learning can substantially improve vanilla meta-learning, which is demonstrated on various few-shot image recognition problems. For example, on 5-way-1-shot image recognition on CIFAR-100 and CUB-200, it improves Matching Nets from 50.53% and 56.53% to 58.18% and 63.47%, improves MAML from 49.28% and 50.45% to 56.65% and 64.63%, and improves Meta-SGD from 53.83% and 53.34% to 61.62% and 66.95%, respectively.
Semiconductor Beacons Light Up Cell Structures (1998)

Quantum dots are all the rage among physicists and chemists. Now these multitalented flecks of semiconductor, which can serve as components in tiny transistors and emit light in rainbow hues, look set to catch biologists' eyes as well. In this issue of Science, two separate teams of researchers report using quantum dots as fluorescent tags capable of tracing specific proteins within cells.
Analysis of Escherichia coli Ribosomal Proteins by an Improved Two Dimensional Gel Electrophoresis. II. Characterization of Fonr New Proteins (1986)

Journal Article Analysis of Escherichia coli Ribosomal Proteins by an Improved Two Dimensional Gel Electrophoresis. II. Characterization of Fonr New Proteins Get access Akira WADA Akira WADA Department of Physics, Faculty of Science, Kyoto UniversitySakyo-ku, Kyoto, Kyoto 606 Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 100, Issue 6, October 1986, Pages 1595–1605, https://doi.org/10.1093/oxfordjournals.jbchem.a121867 Published: 01 October 1986 Article history Received: 19 June 1986 Published: 01 October 1986
Bacillus cereus bacteraemia: comparison between haematologic and nonhaematologic patients (2016)

<i>Bacillus cereus</i> bacteraemia can be severe, especially among patients with haematologic malignancy. We retrospectively reviewed first episodes of true <i>B. cereus</i> bacteraemia (more than one positive bottle plus signs of infection) at our institution between 1997 and 2013 with the aim to compare haematologic versus nonhaematologic patients and analyse episodes with complicated outcome. Among 56 episodes of positive-blood cultures for <i>B. cereus,</i> 21 were considered significant. Median age was 54 years (range 23-82 years). Ten patients (48%) had a haematologic malignancy; all were neutropenic at the time of <i>B. cereus</i> bacteraemia. Nonhaematologic patients were either intravenous drug users (<i>n</i> = 3, 14%), polytraumatized (<i>n</i> = 3, 14%) or had multiple chronic comorbidities (<i>n</i> = 5, 24%). Most episodes were hospital acquired (15, 71%). Sources of bacteraemia were intravascular catheter (<i>n</i> = 11, 52%), digestive tract (<i>n</i> = 6, 29%), drug injection (<i>n</i> = 3, 14%) and wound (<i>n</i> = 1, 5%). Adequate antibiotic therapy was provided to 18 patients (86%) during a median of 17 days (range 2-253 days). The intravascular catheter was removed in eight cases (42%). Three haematologic patients had a complicated course with neurologic complications (meningoencephalitis and cerebral abscesses). Complications appeared to be associated with catheter infection (100% of complicated cases vs. 29% of noncomplicated cases). In conclusion, <i>B. cereus</i> bacteraemia can have a complicated course in a subset of patients, mainly those with haematologic malignancy. Catheter infection may be associated with a worse outcome with frequent neurologic complications.
Liquid chromatography-UV irradiation-hydride generation-atomic fluorescence spectrometry for selenium speciation (2000)

The coupled technique liquid chromatography-UV irradiation-hydride generation-atomic fluorescence spectrometry (LC-UV-HG-AFS) is proposed for selenite, selenate, selenocystine (SeCys) and selenomethionine (SeMet) determination. Separation was performed by using an anionic exchange column and a phosphate buffer as the mobile phase. Hydride generation and UV irradiation were optimised. The detection limits obtained permitted the determination of the four species at trace level concentrations. The method was validated by analysing two water certified reference materials, in which only selenite was detected.
Primary Isolated CABG Restrictive Blood Transfusion Protocol Reduces Transfusions and Length of Stay (2020)

Background: Cardiac surgeries use 10%–15% of red blood cells transfused in the United States, despite benefits of limiting transfusions. We sought to evaluate the the feasibility and impact of a restrictive transfusion protocol on blood use and clinical outcomes in patients undergoing isolated primary coronary artery bypass grafting (CABG). Methods: Blood conservation measures, instituted in 2012, include preoperative optimization, intraoperative anesthesia and pump fluid restriction with retrograde autologous priming and vacuum-assisted drainage, use of aminocaproic acid and cell saver, intra- and postoperative permissive anemia, and administration of iron and lowdose vasopressors if needed. Medical records of patients who underwent isolated primary CABG from 2009–2012 (group A; n=375) and 2013–2016 (group B; n=322) were compared. Results: CABG with grafting to 3 or 4 coronary arteries was performed in 262 (70%) and 222 (69%) patients and bilateral internal thoracic artery grafting in 202 (54%) and 196 (61%) patients in groups A and B, respectively. Mean preoperative and intraoperative hematocrit was 40.3% and 40.7%, 28.9% and 29.4% in groups A and B, respectively. Total blood transfusion was 24% and 6.5%, intraoperative transfusion 10% and 1.2%, postoperative transfusion 19% and 5.3% (p<0.0001 for all) in groups A and B, respectively. Median postoperative length of stay was 5.0 days in group A and 4.5 days in group B (p =.02), with no significant differences between groups in mortality or morbidity. Conclusions: A restrictive transfusion protocol reduced blood transfusions and postoperative length of stay without adversely affecting outcomes following isolated primary CABG.
Block Copolymer Templating Syntheses of Mesoporous Metal Oxides with Large Ordering Lengths and Semicrystalline Framework (1999)

A simple and general procedure has been developed for the syntheses of ordered large-pore (up to 14 nm) mesoporous metal oxides, including TiO2, ZrO2, Nb2O5, Ta2O5, Al2O3, SiO2, SnO2, WO3, HfO2, and mixed oxides SiAlOy, Al2TiOy, ZrTiOy, SiTiOy, ZrW2Oy. Amphiphilic poly(alkylene oxide) block copolymers were used as structure-directing agents in nonaqueous solutions for organizing the network-forming metal oxide species. Inorganic salts, rather than alkoxides or organic metal complexes, were used as soluble and hydrolyzable precursors to the polymerized metal oxide framework. These thermally stable mesoporous oxides have robust inorganic frameworks and thick channel walls, within which high densities of nanocrystallites can be nucleated. These novel mesoporous metal oxides are believed to be formed through a mechanism that combines block copolymer self-assembly with alkylene oxide complexation of the inorganic metal species.
Site-Specific Anticancer Effects of Dietary Flavonoid Quercetin (2013)

Food-derived flavonoid quercetin, widely distributed in onions, apples, and tea, is able to inhibit growth of various cancer cells indicating that this compound can be considered as a good candidate for anticancer therapy. Although the exact mechanism of this action is not thoroughly understood, behaving as antioxidant and/or prooxidant as well as modulating different intracellular signalling cascades may all play a certain role. Such inhibitory activity of quercetin has been shown to depend first of all on cell lines and cancer types; however, no comprehensive site-specific analysis of this effect has been published. In this review article, cytotoxicity constants of quercetin measured in various human malignant cell lines of different origin were compiled from literature and a clear cancer selective action was demonstrated. The most sensitive malignant sites for quercetin revealed to be cancers of blood, brain, lung, uterine, and salivary gland as well as melanoma whereas cytotoxic activity was higher in more aggressive cells compared to the slowly growing cells showing that the most harmful cells for the organism are probably targeted. More research is needed to overcome the issues of poor water solubility and relatively low bioavailability of quercetin as the major obstacles limiting its clinical use.
A Reconfigurable Passive RF-to-DC Converter for Wireless IoT Applications (2019)

In this brief, we present a reconfigurable rectifier, which makes it feasible to harvest energy with net-zero energy consumption, i.e., without draining power from battery, in a wide input power range. The proposed topology can operate with low input power signals and can be fine-tuned for a specific operating frequency in a wide frequency range from several MHz to GHz in remotely powered systems. A prototype is fabricated in 0.35-μm standard CMOS process and occupies 0.019 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Although the proposed rectifier supports four different rectifier topologies, on silicon it only occupies the footprint of a single rectifier. At 13.56 MHz with 2.2 mW input power, the four-switch rectifier topology yields 82% power conversion efficiency (PCE), while the hybrid topology (diodes + switches) provides 81% PCE at 11.2 mW input power. The rectifier operates with input power as low as 1.1 mW, at which level the PCE is still reasonable at 65.2%. This allows a wireless device at low power level to operate at extended read range. This reconfigurable rectifier is especially suitable for Internet of Things mobile application, where the power of the incoming signal changes by the distance between the power source and the device.
Cutting Edge: T Cell Responses to B.1.1.529 (Omicron) SARS-CoV-2 Variant Induced by COVID-19 Infection and/or mRNA Vaccination Are Largely Preserved (2022)

Several studies have demonstrated that the SARS-CoV-2 variant-of-concern B.1.1.529 (Omicron) exhibits a high degree of escape from Ab neutralization. Therefore, it is critical to determine how well the second line of adaptive immunity, T cell memory, performs against Omicron. To this purpose, we analyzed a human cohort (<i>n</i> = 327 subjects) of two- or three-dose mRNA vaccine recipients and COVID-19 postinfection subjects. We report that T cell responses against Omicron were largely preserved. IFN-γ-producing T cell responses remained equivalent to the response against the ancestral strain (WA1/2020), with some (∼20%) loss in IL-2 single or IL-2<sup>+</sup>IFN-γ<sup>+</sup> polyfunctional responses. Three-dose vaccinated participants had similar responses to Omicron relative to post-COVID-19 participants and exhibited responses significantly higher than those receiving two mRNA vaccine doses. These results provide further evidence that a three-dose vaccine regimen benefits the induction of optimal functional T cell immune memory.
Towards semantic services for sensor-rich information systems (2005)

This paper describes the architecture and programming model of a semantic-service-oriented sensor information system platform. We argue that the key to enabling scalable sensor information access is to define an ontology and associated sensor information hierarchy for interpretation of raw data streams. The ontological abstraction allows a sensing system to optimize its resource utilization in collecting, storing, and processing data. We describe the SONGS architecture that uses an automatic service planning to convert declarative user queries into a service composition graph, and performs compile-time and run-time optimizations for resource-aware execution of the service composite in a sensor network, building on the sensor information hierarchy. We motivate and demonstrate the SONGS platform using a parking garage example