gebhart/patrepeval huggingface dataset:
The role of transepithelial transport by M cells in microbial invasion and host defense (1993)

Transepithelial transport of antigens by M cells in the epithelium associated with lymphoid follicles in the intestine delivers immunogens directly to organized mucosal lymphoid tissues, the inductive sites for mucosal immune responses. We have exploited M cell transport to generate and characterize specific monoclonal IgA antibodies that can prevent interaction of pathogens with epithelial surfaces. The relative protective capacities of specific monoclonal IgA antibodies have been tested in vivo by generation of hybridoma tumors that result in secretion of monoclonal IgA into the intestine. Using this method, we have established that secretion of IgA antibodies recognizing a single surface epitope on enteric pathogens can provide protection against colonization or invasion of the intestinal mucosa.
Event - Driven Tactile Learning with Location Spiking Neurons (2022)

The sense of touch is essential for a variety of daily tasks. New advances in event-based tactile sensors and Spiking Neural Networks (SNNs) spur the research in event-driven tactile learning. However, SNN -enabled event-driven tactile learning is still in its infancy due to the limited representative abilities of existing spiking neurons and high spatio-temporal complexity in the data. In this paper, to improve the representative capabilities of existing spiking neurons, we propose a novel neuron model called “location spiking neuron”, which enables us to extract features of event-based data in a novel way. Moreover, based on the classical Time Spike Response Model (TSRM), we develop a specific location spiking neuron model - Location Spike Response Model (LSRM) that serves as a new building block of SNNs <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> The TSRM is the classical SRM in the literature. We add the character “T” to highlight its difference with the LSRM.• Furthermore, we propose a hybrid model which combines an SNN with TSRM neurons and an SNN with LSRM neurons to capture the complex spatio-temporal dependencies in the data. Extensive experiments demonstrate the significant improvements of our models over other works on event-driven tactile learning and show the superior energy efficiency of our models and location spiking neurons, which may unlock their potential on neuromorphic hardware.
Automatic first-breaks picking: New strategies and algorithms (2010)

Abstract We have developed three methods for the automatic picking of first breaks that can be used for marine, dynamite, or vibroseis shot records: a modified Coppens's method, an entropy-based method, and a variogram fractal-dimension method. The techniques are based on the fact that the transition between noise and noise plus signal can be automatically identified by detecting rapid changes in a certain attribute (energy ratio, entropy, or fractal dimension), which we calculate within moving windows along the seismic trace. The application of appropriate edge-preserving smoothing operators to enhance these transitions allowed us to develop an automated strategy that can be used to easily signal the precise location of the first-arrival onset. Furthermore, we propose a mispick-correcting technique to exploit the benefits of the data present in the entire shot record, which allows us to adjust the trace-by-trace picks and to discard picks associated with bad or dead traces. As a result, the consistency of the first-break picks is significantly improved. The methods are robust under noisy conditions, computationally efficient, and easy to apply. Results using dynamite and vibroseis field data show that accurate and consistent picks can be obtained in an automated manner even under the presence of correlated noise, bad traces, pulse changes, and indistinct first breaks.
Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation (2021)

Based on these results, we suggest a role for inflammasome activation/dysregulation in SMI. Our findings further the understanding of possible underlying inflammatory mechanisms and may expose important therapeutic targets in SMI.
Role of FDG PET/CT in Staging of Recurrent Ovarian Cancer (2011)

Ovarian cancer is the fifth leading cause of cancer death among women in the United States and has a high likelihood of recurrence despite aggressive treatment strategies. Detection and exact localization of recurrent lesions are critical for guiding management and determining the proper therapeutic approach, which may prolong survival. Because of its high sensitivity and specificity compared with those of conventional techniques such as computed tomography (CT) and magnetic resonance (MR) imaging, fluorine 18 fluorodeoxyglucose positron emission tomography (PET) combined with CT is useful for detection of recurrent or residual ovarian cancer and for monitoring response to therapy. However, PET/CT may yield false-negative results in patients with small, necrotic, mucinous, cystic, or low-grade tumors. In addition, in the posttherapy setting, inflammatory and infectious processes may lead to false-positive PET/CT results. Despite these drawbacks, PET/CT is superior to CT and MR imaging for depiction of recurrent disease.
KF/alumina catalyzed regioselective benzylation and benzoylation using solvent-free grind-stone chemistry (2012)

Potassium fluoride-impregnated on alumina catalyzes solvent-free regioselective O-benzylation, benzoylation and cinnamylation of phenols. Reaction proceeds simply by triturating together equivalent amounts of phenol and corresponding halide in the presence of 5 mol% of KF/alumina for 5–20 min with a mortar and pestle, without need for any additive such as phase-transfer catalyst or solvent. Key features of the protocol include its efficiency also for solid–solid precursors and regioselectivity for phenolic hydroxyls versus alcoholic hydroxyls. Utility of the protocol for N- and S-benzylation has also been explored. Products were obtained in excellent yields and the catalyst can be easily recycled several times without significant loss of activity.
Bias-line compensation in multi-stage amplifiers (2011)

In this paper, a novel bias-line compensation (BLC) using inverting current buffer for multi-stage amplifiers is proposed. This technique uses a compensation capacitor connected between the output node and low-impedance bias line, which helps in increasing the bandwidth and improving PSRR. The proposed technique is implemented in a widely-adopted low-voltage, high-gain and wide-swing pseudo-class AB amplifier [1]. The amplifier is conventionally compensated with reverse-nested Miller compensation. The results show that bias-line compensation improves the bandwidth by 50% and PSRR by 5dB with ±1.25V power supplies. The amplifier with bias-line compensation is stable for a capacitive load in the range of 1pF to 200pF. The chip was fabricated in a 0.5μm 2P3M process. Measurement results validate the effectiveness of the proposed method.
Cartesian impedance control for dexterous manipulation (2004)

In this work, a cartesian impedance controller purposely designed for dexterous manipulation is described. Based on the main features of the DLR Hand II, concerning kinematic structure and sensory equipment of fingers, this control strategy allows to overcome the main problems encountered in fine manipulation, namely: effects of the friction (and unmodeled dynamics) on robot performances and occurrence of singularity conditions. The achieved control scheme bas been experimentally validated by testing it on a finger of the DLR Hand.
A Novel Mutation of Glutamate Dehydrogenase (H262Y) in an Infant with Hyperinsulinemic Hypoglycemia and Hyperammonemia (2000)

Article A Novel Mutation of Glutamate Dehydrogenase (H262Y) in an Infant with Hyperinsulinemic Hypoglycemia and Hyperammonemia was published on October 1, 2000 in the journal International Journal on Disability and Human Development (volume 1, issue 4).
Dual RNA-seq of Orientia tsutsugamushi informs on host-pathogen interactions for this neglected intracellular human pathogen (2020)

Studying emerging or neglected pathogens is often challenging due to insufficient information and absence of genetic tools. Dual RNA-seq provides insights into host-pathogen interactions, and is particularly informative for intracellular organisms. Here we apply dual RNA-seq to Orientia tsutsugamushi (Ot), an obligate intracellular bacterium that causes the vector-borne human disease scrub typhus. Half the Ot genome is composed of repetitive DNA, and there is minimal collinearity in gene order between strains. Integrating RNA-seq, comparative genomics, proteomics, and machine learning to study the transcriptional architecture of Ot, we find evidence for wide-spread post-transcriptional antisense regulation. Comparing the host response to two clinical isolates, we identify distinct immune response networks for each strain, leading to predictions of relative virulence that are validated in a mouse infection model. Thus, dual RNA-seq can provide insight into the biology and host-pathogen interactions of a poorly characterized and genetically intractable organism such as Ot.
Hypoxia as a physiological cue and pathological stress for coral larvae (2021)

Ocean deoxygenation events are intensifying worldwide and can rapidly drive adult corals into a state of metabolic crisis and bleaching-induced mortality, but whether coral larvae are subject to similar stress remains untested. We experimentally exposed apo-symbiotic coral larvae of Acropora selago to deoxygenation stress with subsequent reoxygenation aligned to their night-day light cycle, and followed their gene expression using RNA-Seq. After 12 h of deoxygenation stress (~2 mg O<sub>2</sub> /L), coral planulae demonstrated a low expression of HIF-targeted hypoxia response genes concomitant with a significantly high expression of PHD2 (a promoter of HIFα proteasomal degradation), similar to corresponding adult corals. Despite exhibiting a consistent swimming phenotype compared to control samples, the differential gene expression observed in planulae exposed to deoxygenation-reoxygenation suggests a disruption of pathways involved in developmental regulation, mitochondrial activity, lipid metabolism, and O<sub>2</sub> -sensitive epigenetic regulators. Importantly, we found that treated larvae exhibited a disruption in the expression of conserved HIF-targeted developmental regulators, for example, Homeobox (HOX) genes, corroborating how changes in external oxygen levels can affect animal development. We discuss how the observed deoxygenation responses may be indicative of a possible acclimation response or alternatively may imply negative latent impacts for coral larval fitness.
Snowfall: Hardware Stream Analysis Made Easy. (2011)

Field-programmable gate arrays (FPGAs) are chip devices that can be runtime-reconfigured to realize arbitrary processing tasks directly in hardware. Industrial products [Net, Xtr] as well as research prototypes [MTA09, MVB + 09, SLS + 10, TMA11] demonstrated how this capability can be exploited to build highly efficient processors for data warehousing,
Is fruit anatomy involved in variation in fruit starch concentration between Actinidia deliciosa genotypes? (2010)

The role of anatomical traits in carbohydrate accumulation was investigated in fruit of Actinidia deliciosa (A. Chev.) C. F. Liang et A. R. Ferguson (kiwifruit) var. deliciosa by comparing high and low dry matter (DM) accumulating genotypes. DM was shown previously to be correlated with starch concentration in these fruit. Volume proportions of the three fruit tissues (outer pericarp, inner pericarp and central core) did not vary significantly between genotypes or contribute to variation in total fruit DM. The outer pericarp of the kiwifruit berry contains both small and large cells: the size of these cells was not correlated with final fruit size. In high DM genotypes, the relative volume of outer pericarp tissue occupied by small cells (50%) was significantly greater than that in low DM genotypes (43%). Small cells have a higher starch concentration than large cells: the larger proportion of small cells in the outer pericarp of fruit from high DM genotypes accounted for approximately +25% of the measured differences in fruit starch concentration between high and low DM genotypes. We conclude that, although anatomical traits contribute to variation in fruit starch concentration between kiwifruit genotypes, differences in starch content per small cell are important and worthy of further investigation. This is the first time anatomical investigations have been used to examine differences in fruit carbohydrate accumulation in kiwifruit.
Visual syntax does matter: improving the cognitive effectiveness of the i* visual notation (2010)

Goal-oriented modelling is one of the most important research developments in the requirements engineering (RE) field. This paper conducts a systematic analysis of the visual syntax of i*, one of the leading goal-oriented languages. Like most RE notations, i* is highly visual. Yet surprisingly, there has been little debate about or modification to its graphical conventions since it was proposed more than a decade ago. We evaluate the i* visual notation using a set of principles for designing cognitively effective visual notations (the Physics of Notations). The analysis reveals some serious flaws in the notation together with some practical recommendations for improvement. The results can be used to improve its effectiveness in practice, particularly for communicating with end users. A broader goal of the paper is to raise awareness about the importance of visual representation in RE research, which has historically received little attention.
High-Speed Rail: International Lessons for U.S. Policy Makers (2011)

An initial investment of $10.1 billion was made in 2009-2010 in the U.S. High-Speed Intercity Passenger Rail Program. However, due to the difficult fiscal environment, California is currently the only federally funded Core Express high-speed rail project moving forward. In 2011 Congress voted to strip funding from the program. The expiration of the legislation authorizing the high-speed rail program in 2013 provides an opportunity to consider policy changes. This report discusses several funding strategies that have proven to be successful in other countries. Specific policy recommendations are made to better position the federal high-speed rail program for success. Briefly, these are: Strengthen the federal policy and management framework; Prioritize corridors that meet investment criteria; Establish new mechanisms for corridor management; Plan for maximum land development benefits; Focus initially on the Northeast Corridor and California; and Secure adequate and reliable funding.
Synthetic waveforms of axial motion in a borehole with drill string (2017)

This work studies the wave motion in a fluid-filled borehole in the presence of drill string and geological formation. The synthetic waveforms are obtained by a three-dimensional axis-symmetric full-wave numerical simulation in a two-dimensional multi-domain where the medium is uniform with respect to the azimuth. The discretization is performed in cylindrical coordinates. In order to simulate the waves at the origin (axis of the polar radius), a very small radius is used to avoid the singularity. The free-surface and rigid boundary conditions are tested and it is shown that the rigid one constitutes the best approximation. The simulations provide the amplitude distribution and motion diagrams in the borehole vertical cross-sections and at the outer boundary, away from the borehole. Propagation in the presence of hard and soft formations is analysed. The dispersion, the amplitude, and the orbital polarization of the modes excited by a point source acting in the fluid inside a drillstring are considered and examples of comparison with literature results obtained using multi-modal analysis are shown. The proposed approach is more general than the multi-modal analysis, since it allows for arbitrary variations of the properties in the plane of symmetry.
Predictores de recurrencia y resultados en la ablación de la fibrilación auricular paroxística (2025)

Introducción: El aislamiento de las venas pulmonares es actualmente la terapéutica de elección en pacientes con fibrilación auricular paroxística, sintomática y refractaria al tratamiento antiarrítmico. Diferentes grupos abocados al tratamiento de la fibrilación auricular paroxística han publicado su experiencia y se conocen varios predictores de recurrencia. Sin embargo, hasta el presente no se ha reportado en nuestro medio una experiencia similar. Objetivos: Primario: Analizar los predictores de recurrencia posaislamiento de venas pulmonares con radiofrecuencia. Secundario: Evaluar la tasa de éxito y las complicaciones asociadas con el procedimiento. Material y métodos: Análisis prospectivo, observacional, unicéntrico, realizado entre mayo de 2009 y agosto de 2015 de 1.000 casos consecutivos de ablación de fibrilación auricular paroxística con radiofrecuencia y mapeo electroanatómico. Para el análisis del seguimiento se utilizaron 507 aislamientos de venas pulmonares con al menos un año de seguimiento, excluyendo las reablaciones y los pacientes que no cumplieron con todas las visitas de seguimiento. Resultados: En un análisis multivariado utilizando regresión de Cox se observó que la mayor frecuencia de episodios de fibrilación auricular previos a la ablación [HR 1,354 (1,059-1,732); p = 0,016] y la recurrencia temprana (0-3 meses) [HR 4,006 (2,703-5,937); p &lt; 0,0001] fueron los predictores más significativos de recurrencia a los 12 meses. La tasa de mantenimiento de ritmo sinusal al año sin tratamiento antiarrítmico fue del 77,5% para fibrilación auricular paroxística, con una recurrencia del 22,5%. Las complicaciones fueron taponamiento cardíaco con pericardiocentesis en 16 pacientes (1,6%), complicaciones vasculares en 21 (2,1%), ataque isquémico transitorio en 2 (0,2%), parálisis del nervio frénico en 1 (0,1%), pericarditis en 5 (0,5%) y hemotórax en 1 (0,1%). Conclusiones: La mayor frecuencia de episodios de fibrilación auricular previos al aislamiento de venas pulmonares y la recurrencia temprana favorecen la recurrencia al año. El aislamiento de venas pulmonares es un método seguro y eficaz para el control del ritmo en pacientes con fibrilación auricular paroxística, sintomática y refractaria al tratamiento antiarrítmico, con una tasa baja de complicaciones.
Non-steroidal anti-inflammatory drugs and statins in relation to colorectal cancer risk (2009)

Although our results confirm the inverse association between NSAIDs use and colorectal cancer risk, they do not support a risk reduction in statin users, or an interaction effect of combined NSAIDs and statin use.
Preparation of Porous Anatase Coating from Sol‐Gel‐Derived Titanium Dioxide and Titanium Dioxide‐Silica by Water‐Vapor Exposure (1999)

The effects of water vapor on the crystallization behavior of sol‐gel‐derived titanium dioxide (TiO 2 ) thin films that contained 0‐50 mol% silica (SiO 2 ) were investigated. Anatase formed on exposure to water vapor at 60°‐180°C, with a simultaneous decrease in the concentration of OH groups. An increase in the SiO 2 content of the exposed films led to an increase in the average crystalline size. Because crystallization of the exposed films of the films was not accompanied by shrinkage, porous anatase coatings were obtained via exposure at a relatively low temperature. Phase separation of the immiscible TiO 2 ‐SiO 2 system was induced with water vapor, which resulted in acceleration of the crystallization of the sol‐gel films.
Immunological observations and transcriptomic analysis of trimester‐specific full‐term placentas from three Zika virus‐infected women (2019)

These findings should translate to improve clinical prenatal screening procedures for virus-infected pregnant patients.
Modelling and Simulation of GPS Multipath Propagation (2020)

Multipath introduces error into the Global Positioning System (GPS) accuracy, which is difficult to mitigate. This paper aims to review the multipath propagation and its effect on GPS applications, through the modeling of a single reflected signal propagation behavior. Furthermore, the multipath rejection of two commercially available GPS antennas are studied. It is observed that shaping the antenna radiation pattern as well as its polarisation properties plays an important role in mitigating the multipath error.
Iso-Carrier Density Comparison of Compensation Effects on Highly Doped Solargrade Silicon Solar Cells (2010)

This study investigates the compensation effects at iso-carrier density on two intentionally compensated multicrystalline ingots grown from Solar-Grade Silicon feedstocks purified using metallurgical routes. The effects of the dopant compensation on both ingots were studied at the wafer and the solar cell levels at given equilibrium carrier densities, in order to allow a relevant investigation of the compensation effects on the overall electrical properties. At the wafer level the majority carrier mobility and the carrier lifetime were investigated. At the cell level, I-V characteristics under standard illumination were studied. In the light of all the characterization results, we propose physical mechanisms that explain the iso-carrier density differences in electrical properties observed between the two ingots.
The Past, Present, and Future of Geodemographic Research in the United States and United Kingdom (2013)

This article presents an extensive comparative review of the emergence and application of geodemographics in both the United States and United Kingdom, situating them as an extension of earlier empirically driven models of urban socio-spatial structure. The empirical and theoretical basis for this generalization technique is also considered. Findings demonstrate critical differences in both the application and development of geodemographics between the United States and United Kingdom resulting from their diverging histories, variable data economies, and availability of academic or free classifications. Finally, current methodological research is reviewed, linking this discussion prospectively to the changing spatial data economy in both the United States and United Kingdom.
Investigation of Ru/TiN Bottom Electrodes Prepared by Chemical Vapor Deposition (2004)

Ru thin films were prepared by metalorganic chemical vapor deposition (MOCVD) using cyclopentadienyl-propylcyclopentadienlylruthenium(II) [RuCp(i-PrCp)] and the nucleation behaviors of Ru films on Ta 2 O 5 , TiN, Si 3 N 4 , SiO 2 , TiO 2 substrates were investigated. It appeared that the difference in nucleation behaviors on various substrates is due to the bonding type between atoms in substrate materials. The nucleation property of Ru films on TiN was successfully improved by plasma treatment of the TiN substrate using Ar before film deposition. It was found that the Ar plasma treatment selectively removes N ions from the surface, makes the TiN surface more metallic or ionic (due to the residual Ti-O bonding), and reduces the nucleation barrier. In addition, the oxidation resistance of Ru/TiN layers was improved by H 2 annealing, which made the Ru films more dense.