gebhart/patrepeval huggingface dataset:
Macrophage Infiltration and Cellular Proliferation in the Non-Ischemic Kidney and Heart following Prolonged Unilateral Renal Ischemia (2007)

Rather than affecting a single organ, the present study demonstrates that after prolonged renal ischemia, the contralateral kidney and heart undergo changes in growth factor and chemokine expression, resulting in pathological proliferation and inflammation that can be modulated by blockade of the AT1 receptor.
On the performance of signal-subspace processing-- Part I: Narrow-band systems (1986)

This paper presents an analytical evaluation of detection (determination of the number of sources) and estimation performances of narrow-band signal-subspace processing for multiple-source direction finding. The probabilities of underestimating and overestimating the number of sources are derived, under asymptotic conditions and around the threshold regions, in terms of the choice of a penalty function and signal, noise, and array parameters for the cases of at most two closely spaced sources in the spatially white noise. A scalar measure is introduced for the evaluation of the quality of the estimated signal subspace. Based on the statistics of this measure, performance thresholds are demonstrated for the signal-to-noise ratio, angle separation, and correlation between two equipowered sources.
Arthrobacter siderocapsulatus Dubinina and Zhdanov 1975AL is a later subjective synonym of Pseudomonas putida (Trevisan 1889) Migula 1895AL. (2001)

The taxonomic position of Arthrobacter siderocapsulatus Dubinina and Zhdanov 1975AL was investigated using 16S rDNA, fatty acid and phenotypic analyses. The type strain (NCIMB 11286T) showed 99.85% 16S rDNA similarity to the type strain of Pseudomonas putida. Phenotypic properties of the two strains were compared using API 20NE and BIOLOG kits. Identical reactions were recorded for all tests, except for assimilation of malonic acid. The two strains also showed almost identical cellular fatty acid profiles. On the basis of evidence presented in this and earlier studies, it is proposed that Arthrobacter siderocapsulatus is a later subjective synonym of Pseudomonas putida (Trevisan 1889) Migula 1895AL.
Nuts & bolts (2002)

Take a loony with his pet frog and lunchtime atop a skyscraper will never be the same again. 3D animation, compositing, and procedural city scape.
Fabric Ignition by Flame Impingement (1980)

An apparatus has been constructed and data evaluation techniques developed for quantifying the ease of ignition of fabrics exposed to a small flame. The method takes careful account of fabric moisture content, which can have a substantial influence on this form of ignitability. A proposed specific ignition resistance coefficient, obtained from yes-no trials at preset exposure times, is inde pendent of fabric weight and ambient humidity, so that ignitability can be compared on a common basis.
DNA repair-based classification of melanoma cell lines reveals an effect of mutations in BRAF and NRAS driver genes on DNA repair capacity (2020)

Abstract Melanoma, the most serious form of skin cancer, frequently involves the dysregulation of key signaling pathways. Treatment strategies presently target the MAPK/ERK pathway, which is overactive in melanomas due in part to BRAF and NRAS mutations, and involve inhibitors against mutated BRAF (vemurafenib or dabrafenib) or MEK kinases (cobimetinib or trametinib), or a combination of the two. Using an established biochip technology, we assessed base excision repair (BER) and nucleotide excision repair (NER) activities in a collection of BRAF mutated (A-375, Colo 829, HT-144, Malme-3M, SK-mel5, SK-mel24 and SK-mel28) and NRAS mutated (M18, MZ2 and SK-mel2) melanoma cell lines, as well as wild-type controls (A7, CHL-1). We evaluated both basal activities (i.e., without treatment) and repair capacities after treatment with vemurafenib or cobimetinib alone, or in combination. Our results indicate that globally the DNA repair capacity of the cell lines was determined by the mutation status of the BRAF and NRAS genes, indicating that the MAPK pathway participates in the regulation of both BER and NER. Treatment of BRAF mutated melanoma cells with vemurafenib alone or the vemurafenib/cobimetinib combination, but not cobimetinib alone, led to reduced DNA repair capacity in about 60% of the BRAF mutated samples, indicating that signaling pathway inhibition can alter DNA repair activity. Upregulation of some DNA repair activities was also observed in several of the treated samples, suggesting activation of compensatory signaling pathways upon treatment. The data collectively indicate that mutations in the BRAF and NRAS genes exert distinct regulatory effects on the excision/synthesis steps of the BER and NER pathways and that targeted pharmacological inactivation of the signaling mechanism can translate into specific consequences in DNA repair capacity. The heterogeneity of the responses reported herein could help define subtypes of melanoma that are associated with resistance to targeted therapies.
Shape-Based Image Retrieval Using Spatio-Temporal Relation Computations (2001)

Content-based retrieval of multimedia information is one of the most difficult research topics in multimedia computing and information retrieval. In this paper, we present a visual system which allows content-based retrieval of still image. The recognition algorithms we used are based on spatio-temporal relations. Two approaches and algorithms were developed based on the similarity between polygons. The system is incorporated with a visual interface which allows the user to specify polygons as the shape specification of pictures. The preliminary experience shows that, within an image database containing about 300 bitmapped images, the system is able to retrieve correct information of a high satisfaction.
Is there a Future for the STEM? (1978)

By this time virtually everyone involved in electron microscopy has heard of the STEM, many are familiar with some of its capabilities and a few--a very few--are expert in Its use. This type of microscope has been worthy of notice for only a very few years because it was only in 1971 that we were able to show that it was a serious contender in the high resolution game by demonstrating that it could produce images of heavy atoms (Crewe et al., 1970).
Advantages of RuOx Bottom Electrode in the Dielectric and Leakage Characteristics of (Ba,Sr)TiO 3 Capacitor (1996)

The crystal structure and electrical properties of (Ba,Sr)TiO 3 (BST) films were investigated with three different bottom electrodes, Ti/Pt, RuO x and RuO x /Pt. On the RuO x and RuO x /Pt electrodes BST films were preferentially grown along the same orientations of electrodes, whereas BST films have no preferential orientation on the Pt electrode. The interfacial reaction, oxygen deficiency and hillock formation in the BST capacitors were obviously prevented by the RuO x bottom electrode, resulting in a high dielectric constant (300–305) and low leakage current density (10 -9 A/cm 2 ).
The synthesis of LiMo4O6, Zn0.5Li Mo4O6 and Li Mo4O6 (x ≈ 0.1) from InMo4O6 (1995)

Ion exchange and intercalation chemistry of InMo4O6 were found to be possible due to the open channels in this structure (approximately 1.95Åacross at narrowest constriction). The In+ cation could be replaced with Li+ via ion exchange, with little change in the lattice parameters of the structure (InMo4O6a = 9.665(1)Å, c = 2.864(1)Å; LiMo4O6a = 9.698(1)Å, c = 2.855(1)Å) due to the rigidity of the bonds holding the Mo4O6 structural framework together. Most of the Li+ could then be removed by reaction with an iodine solution in acetonitrile. Zinc or indium cations could then be intercalated into the “empty” structure at relatively low temperatures (500 °C).
Hypermutation takes the driver’s seat (2015)

Most pediatric tumors have only very few somatic mutations. However, a recent study revealed that a subset of tumors from children with congenital biallelic deficiency of DNA mismatch repair exhibits a mutational load surpassing almost all other cancers. In these ultra-hypermutated tumors, somatic mutations in the proofreading DNA polymerases complement the congenital mismatch repair deficiency to completely abolish replication repair, thereby driving tumor development. These findings open several possibilities for exploiting ultra-hypermutation for cancer therapy.
Small fields: Nonequilibrium radiation dosimetry (2007)

Advances in radiation treatment with beamlet-based intensity modulation, image-guided radiation therapy, and stereotactic radiosurgery (including specialized equipments like CyberKnife, Gamma Knife, tomotherapy, and high-resolution multileaf collimating systems) have resulted in the use of reduced treatment fields to a subcentimeter scale. Compared to the traditional radiotherapy with fields > or =4 x 4 cm2, this can result in significant uncertainty in the accuracy of clinical dosimetry. The dosimetry of small fields is challenging due to nonequilibrium conditions created as a consequence of the secondary electron track lengths and the source size projected through the collimating system that are comparable to the treatment field size. It is further complicated by the prolonged electron tracks in the presence of low-density inhomogeneities. Also, radiation detectors introduced into such fields usually perturb the level of disequilibrium. Hence, the dosimetric accuracy previously achieved for standard radiotherapy applications is at risk for both absolute and relative dose determination. This article summarizes the present knowledge and gives an insight into the future procedures to handle the nonequilibrium radiation dosimetry problems. It is anticipated that new miniature detectors with controlled perturbations and corrections will be available to meet the demand for accurate measurements. It is also expected that the Monte Carlo techniques will increasingly be used in assessing the accuracy, verification, and calculation of dose, and will aid perturbation calculations of detectors used in small and highly conformal radiation beams. rican Association of Physicists in Medicine.
Setting Performance Goals and Evaluating Total Analytical Error for Diagnostic Assays (2002)

Total analytical error should be estimated either directly by the distribution-of-differences method or by simulation. A systems engineering approach that uses allocation of the total analytical error goal into error source goals provides a cost-effective approach to meeting total analytical error. Because outliers can cause serious laboratory error, the inclusion of outlier rate estimates from large studies (e.g., those conducted by manufacturers) would be helpful in assessing assay quality.
Chapter 4. Air quality and climate in the Mediterranean region (2016)

Ambient air ranks number one among the natural resources vital to human beings, with an average individual daily need of 12 kg. Due to the specificities of the Mediterranean region (sunny, hot and dry climate; long-range transport converging over the basin), air pollution in reactive compounds over the Mediterranean is often higher than in most European inland regions. Climate change (increase in temperature and drought) and anthropogenic pressure (growing population) should significantly impact the regional air quality. As a result, Mediterranean inhabitants who are already regularly exposed to pollutant loads well above WHO air quality recommendations will be further exposed, resulting in an excess of premature deaths. Exposure monitoring and win-win strategies should be developed in the future both to improve air quality and develop a low carbon economy. The evolution of emissions under climate change is not always clear and much uncertainty remains around present emissions from large urban-industrial centers, although recent progress has been made on emissions of the different regional sources of pollutants. It has been established that the regional climate and water cycle are affected by atmospheric chemistry. By reducing solar radiation at the surface, aerosols reduce the yearly average precipitation in the Mediterranean by 10%, which is a major issue since water is already scarce. Aerosols could further reduce precipitations by reducing the size of cloud droplets or through the formation of cloud droplets and ice crystals. Moreover, recent in situ and model experiments indicate that anthropogenic nitrogen and desert dust phosphorus deposition in nutrient-depleted surface seawater favors phytoplankton development, which stimulates the sink of atmospheric CO2 into marine sediments. But Saharan dust deposition by rain also stimulates bacterial growth, which reemits CO2. The net effect of desert dust deposition at large scales needs to be established.
A Three-Way Accuracy Comparison of the Dexcom G5, Abbott Freestyle Libre Pro, and Senseonics Eversense CGM Devices in an Outpatient Study of Subjects with Type 1 Diabetes (2018)

There are no published studies directly comparing the accuracy of continuous glucose monitoring (CGM) devices in the outpatient setting. We tested the performance of the Dexcom G5, Abbot Freestyle Libre Pro, and Senseonics Eversense (an implantable CGM approved in Europe) during a 6-week, free-living, outpatient bionic pancreas study involving 23 subjects with type 1 diabetes who wore all 3 devices concomitantly. The primary outcome was the mean absolute relative difference (MARD) vs. plasma glucose (PG) values measured with the Nova Biomedical StatStrip Xpress meter that was also used for calibrations according to the manufacturer's instruction (except for Libre Pro that is not calibrated). We compared PG values with CGM readings when they were available from all 3 CGMS in the 5 minutes preceding the PG values (n=829 sets). Since the Libre Pro records readings every 15 minutes, we also did a two-way comparison between the G5 and the Eversense that allowed a higher number of comparisons (n=2277 sets). Statistical significance was determined using a repeated measurements model fitted with the generalized estimating equation method. All 3 CGM systems produced higher average MARDs than during in-clinic studies. However, since all three CGM systems were worn by the same individuals and used the same meter for calibration and as comparator, we were able to directly compare their performance under real-world conditions. In the 3-way comparison Eversense achieved the lowest nominal MARD (14.8%) followed by Dexcom G5 (16.3%) and Libre Pro (18.0%) (Eversense vs. Libre Pro p=0.004, other comparisons p=NS). In the 2-way comparison the MARD difference between Eversense (15.1%) and G5 (16.9%) was statistically significant (p=0.008). We found that the point accuracy of the Eversense was significantly better than two other CGM systems. The Eversense CGM system may be useful to provide glucose values to artificial pancreas devices. Disclosure R.Z. Jafri: None. C.A. Balliro: None. F. El-Khatib: Stock/Shareholder; Self; Beta Bionics. Employee; Self; Beta Bionics. M. Maheno: None. M.A. Hillard: None. A.J. O'Donovan: None. R. Selagamsetty: None. H. Zheng: None. E. Damiano: Other Relationship; Self; Beta Bionics. S.J. Russell: Other Relationship; Self; Beta Bionics, Novo Nordisk Inc.. Advisory Panel; Self; Companion Medical, Tandem Diabetes Care, Inc., Unomedical a/s. Research Support; Self; Beta Bionics, Zealand Pharma A/S, MITRE Corporation.
Endoscopic spine surgery—increasing usage and prominence in mainstream spine surgery and spine societies (2020)

While Dr. Parvis Kambin described the first endoscopic view of the herniated disc in 1988, technical and technological limitations prevented initial widespread adoption of spinal endoscopy (1). However, shortly thereafter, Dr. Kambin’s description of the safe working zone, Kambin’s triangle (2), helped to establish the viability of endoscopic and other minimally invasive spinal surgical (MISS) techniques. A relatively rapid expansion in the number of relevant surgical techniques followed over the next several decades.
Projective Surface Matching of Colored 3D Scans (2005)

We present a new method for registering multiple 3D scans of a colored object. Each scan is regarded as a color and range image of the object recorded by a pinhole camera. Consider a pair of cameras that see overlapping parts of the objects. For correct camera poses, the actual image of the overlap area in one camera matches the rendition of the overlap area as seen by the other camera. We define a mismatch score summarizing discrepancies in color, range, and silhouette between pairs of images, and we present an algorithm to efficiently minimize this mismatch score over camera poses.
Variation in Photosynthetic Pigments and Plastoquinone Contents in Sugar Beet Chloroplasts with Changes in Leaf Copper Content (1984)

The changes in the contents of chlorophyll (Chl) a, Chl b, carotenoid, and plastoquinone in sugar beet (Beta vulgaris) chloroplasts were investigated during Cu deficiency and resupply. With the onset of Cu deficiency, extrachloroplastic Cu decreased more rapidly than chloroplast Cu, which eventually accounted for all of the Cu present in the leaf. The ultrastructure of Cu-deficient chloroplasts did not differ from the control except in very young, severely deficient leaves. During Cu depletion and resupply, Chl a, Chl b, carotenoid, and plastoquinone contents changed concomitantly. Because of the concurrent changes in the contents of terpenoid-containing pigments and plastoquinone with Cu depletion and resupply, we suggest that Cu might be involved in the regulation of the early steps of terpenoid biosynthesis prior to the formation of geranyl-geranyl-pyrophosphate.
Vibrational and Rotational Collision Processes (1980)

This chapter contains sections titled: Introduction Survey of Experimental Methods Intermolecular Potentials Dynamics Kinematics Inversion of Experimental Data Sensitivity Analysis in Molecular Dynamics
Crizotinib in Combination With Chemotherapy for Pediatric Patients With ALK+ Anaplastic Large-Cell Lymphoma: The Results of Children's Oncology Group Trial ANHL12P1 (2022)

Arm CZ of ANHL12P1 demonstrated that the addition of CZ to standard treatment prevented relapses during therapy for children with ALCL, MDD predicted EFS, and the addition of CZ resulted in unexpected thromboembolic events. Overall survival and EFS rates are consistent with the highest reported outcomes for children with ALCL.
The Next Influenza Pandemic (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Calculation Study on the Synthesis Routes of Oh-Al<sub>13 </sub>Cluster (2011)

Based on the method of LST/QST improved in the molecular orbital DMol 3 program, with the aid of the minimum energy path (MEP) in the climbing image nudged elastic band (CI-NEB) method, the Oh-Al 13 cluster is investigated under different synthesis process, i.e . Al 6 +Al 7 →Al 13 . The results show that: there are two stages in the synthesis reaction: the distortion stage and the configuration revolution stage. In the first stage, the metastable structures are forced to change into stable structures. In the configuration evolution stage, two different cases exist. For the synthesis of crystal clusters it is an automatic exothermic reaction if all reactants being of typical crystal symmetrical elements, i.e., Al 6 +Al 7M ®Oh-Al 13 . While an energy barrier must be overcome if one of reactants having fivefold or tenfold symmetrical axes, i.e .,Al 6 +Al 7 、Al 6M +Al7 and Al 6M +Al 7M . So the five-symmetry structures are only appearing in rapidly solidified processes except crystallization processes.
Mutation analysis in the coding sequence of thymidine kinase 1 in breast and colorectal cancer (2003)

We report the first mutational study of thymidine kinase 1 (TK1) performed in human solid tumors. We sequenced cDNAs representing the complete coding region of TK1 in human breast (n=22) and colorectal (n=26) cancer. Codon 106 near the ATP binding site constantly differed (ATG --> GTG; Met --> Val) from the one deposited by Bradshaw and Deininger in the Genbank database (Accession number NM_003258). Silent polymorphisms at codon 11 (CCC --> CCT; Pro --> Pro) and codon 75 (GCG --> GCA; Ala --> Ala) were frequently detected in tumors as well as in normal tissues. In breast cancer the two polymorphisms were observed in 63.6% of the samples analyzed. No significant association could be found between polymorphisms and TK activity. In colorectal cancer the incidence of the two changes was 73.1% and 69.2%, respectively. Interestingly, one colon cancer with high cytosolic TK activity displayed two missense mutations located in and near the putative phosphorylation site by tyrosine kinase (s) (TAT --> CAT; Tyr --> His) and by cAMP-, cGMP-dependent protein kinase (TAC --> TGC; Tyr --> Cys), respectively; adjacent normal mucosa showed no mutation. This may open new avenues that imply TK1 activity in tumor cell proliferation.
Placental amino acid transport (1995)

Normal fetal growth and development depend on a continuous supply of amino acids from the mother to the fetus. The placenta is responsible for the transfer of amino acids between the two circulations. The human placenta is hemomonochorial, meaning that the maternal and fetal circulations are separated by a single layer of polarized epithelium called the syncytiotrophoblast, which is in direct contact with maternal blood. Transport proteins located in the microvillous and basal membranes of the syncytiotrophoblast are the principal mechanism for transfer from maternal blood to fetal blood. Knowledge of the function and regulation of syncytiotrophoblast amino acid transporters is of great importance in understanding the mechanism of placental transport and potentially improving fetal and newborn outcomes. The development of methods for the isolation of microvillous and basal membrane vesicles from human placenta over the past two decades has contributed greatly to this understanding. Now a primary cultured trophoblast model is available to study amino acid transport and regulation as the cells differentiate. The types of amino acid transporters and their distribution between the syncytiotrophoblast microvillous and basal membranes are somewhat unique compared with other polarized epithelia. These differences may reflect the unusual circumstance of this epithelium that is exposed to blood on both sides. The current state of knowledge as to the types of transport systems present in syncytiotrophoblast, their regulation, and the effects of maternal consumption of drugs on transport are discussed.