gebhart/patrepeval huggingface dataset:
Baseline Retrobulbar Blood Flow is Predictive of Retinal Nerve Fiber Layer Thickness in Patients with Glaucoma (2012)

Purpose: To examine if baseline retrobulbar blood flow as measured by color Doppler imaging (CDI) is predictive of retinal nerve fiber layer (RNFL) thickness in patients with open angle glaucoma (OAG). Methods: CDI and optical coherence tomography (OCT) parameters at baseline were analyzed as predictors of RNFL thickness after 2 years of follow up using Pearson correlation coefficients. Results: In 100 patients with OAG, baseline retrobulbar blood flow parameters were positively correlated with 2-year retinal nerve fiber layer (RNFL) thickness measurements. Ophthalmic artery (OA) end diastolic velocity (EDV) at baseline was positively correlated to 2-year inferior RNFL thickness (r=0.2, p=0.0432), temporal RNFL thickness (r=0.22, p=0.0252), and RNFL average thickness (r=0.25, p=0.0129) as measured by OCT. Central retinal artery (CRA) peak systolic velocity (PSV) at baseline was positively correlated with 2-year superior RNFL thickness (r=0.27, p=0.0062), nasal RNFL thickness (r=0.28, p=0.0045), and average RNFL thickness (r=0.27, p=0.0064). CRA EDV at baseline was positively correlated with 2-year superior RNFL thickness (r=0.23, p=0.0193), nasal RNFL thickness (r=0.22, p=0.0295), and average RNFL thickness (r=0.24, p=0.014). Nasal posterior ciliary artery (NPCA) PSV at baseline was positively correlated with 2-year superior RNFL thickness (r=0.32, p=0.0013), inferior RNFL thickness (r=0.24, p=0.0177), nasal RNFL thickness (r=0.23, p=0.0246), and RNFL average thickness (r=0.29, p=0.0037). NPCA EDV at baseline was positively correlated with 2-year superior RNFL thickness (r=0.38, p=0.0001), inferior RNFL thickness (r=0.33, p=0.0009), nasal RNFL thickness (r=0.24, p=0.017), and RNFL average thickness (r=0.37, p=0.0001). Temporal posterior ciliary artery (TPCA) PSV at baseline was positively correlated with 2-year superior RNFL thickness (r=0.28, p=0.0051). TPCA EDV at baseline was positively correlated with
Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments (2020)

ABSTRACT Defining the principles of T cell migration in structurally and mechanically complex tumor microenvironments is critical to understanding sanctuaries from antitumor immunity and optimizing T cell-related therapeutic strategies. To enhance T cell migration through complex microenvironments, we engineered nanotextured platforms that allowed us to define how the balance between T cell phenotypes influences migration in response to tumor-mimetic structural and mechanical cues and characterize a mechanical optimum for migration that can be perturbed by manipulating an axis between microtubule stability and force generation. In 3D environments and live tumors, we demonstrate that microtubules instability, leading to increased Rho pathway-dependent cell contractility, promotes migration while clinically used microtubule-targeting chemotherapies profoundly decrease effective migration. Indeed, we show that rational manipulation of the microtubule-contractility axis, either pharmacologically or through genome engineering, results in engineered T cells that more effectively move through and interrogate 3D matrix and tumor volumes. This suggests that engineering cells to better navigate through 3D microenvironments could be part of an effective strategy to enhance efficacy of immune therapeutics.
Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer (2010)

The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors. To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we undertook a two-staged genome-wide association study in BRCA2 mutation carriers. In stage 1 using the Affymetrix 6.0 platform, 592,163 filtered SNPs genotyped were available on 899 young (, 40 years) affected and 804 unaffected carriers of European ancestry. Associations were evaluated using a survival-based score test adjusted for familial correlations and stratified by country of the study and BRCA2*6174delT mutation status. The genomic inflation factor (lambda) was 1.011. The stage 1 association analysis revealed multiple variants associated with breast cancer risk: 3 SNPs had p-values, 10 25 and 39 SNPs had p-values&lt;10(-4). These variants included several previously associated with sporadic breast cancer risk and two novel loci on chromosome 20 (rs311499) and chromosome 10 (rs16917302). The chromosome 10 locus was in ZNF365, which contains another variant that has recently been associated with breast cancer in an independent study of unselected cases. In stage 2, the top 85 loci from stage 1 were genotyped in 1,264 cases and 1,222 controls. Hazard ratios (HR) and 95% confidence intervals (CI) for stage 1 and 2 were combined and estimated using a retrospective likelihood approach, stratified by country of residence and the most common mutation, BRCA2*6174delT. The combined per allele HR of the minor allele for the novel loci rs16917302 was 0.75 (95% CI 0.66-0.86, p = 3: 8 x 10(-5)) and for rs311499 was 0.72 (95% CI 0.61-0.85, p = 6: 6 x 10(-5)). FGFR2 rs2981575 had the strongest association with breast cancer risk (per allele HR = 1.28, 95% CI 1.18-1.39, p = 1: 2 x 10(-8)). These results indicate that SNPs that modify BRCA2 penetrance identified by an agnostic approach thus far are limited to variants that also modify risk of sporadic BRCA2 wild-type breast cancer.
The Power of an Infant's Smile: Maternal Physiological Responses to Infant Emotional Expressions (2015)

Infant emotional expressions, such as distress cries, evoke maternal physiological reactions. Most of which involve accelerated sympathetic nervous activity. Comparatively little is known about effects of positive infant expressions, such as happy smiles, on maternal physiological responses. This study investigated how physiological and psychological maternal states change in response to infants' emotional expressions. Thirty first-time mothers viewed films of their own 6- to 7-month-old infants' affective behavior. Each observed a video of a distress cry followed by a video showing one of two expressions (randomly assigned): a happy smiling face (smile condition) or a calm neutral face (neutral condition). Both before and after the session, participants completed a self-report inventory assessing their emotional states. The results of the self-report inventory revealed no effects of exposure to the infant videos. However, the mothers in the smile condition, but not in the neutral condition, showed deceleration of skin conductance. These findings demonstrate that the mothers who observed their infants smiling showed decreased sympathetic activity. We propose that an infant's positive emotional expression may affect the branch of the maternal stress-response system that modulates the homeostatic balance of the sympathetic and parasympathetic nervous systems.
Induction of Cell Death of Gastric Cancer Cells by a Modified Compound of the Annonaceous Acetogenin Family (2003)

Annonaceous acetogenins are a family of natural products with antitumor activities. The polyether mimic AA005 has been synthesized. The cytotoxic mechanism of AA005 was investigated. It was found that AA005 can induce the cell death of gastric tumor cells. Most AA005-induced cell death is due to necrosis but partial and p53-independent apoptosis is also detected. An expanded study with gastric tumor cells and a cell-free system indicates that AA005 affects NADH:ubiquinone oxidoreductase (complex I; NADH=nicotinamide adenine dinucleotide, reduced form) in the mitochondrial electron transport system. These results show for the first time that the polyether mimic AA005 acts on the same biological target as the natural annonaceous acetogenins.
Standards incorporated by reference in the legislation – the Canadian context (2015)

fichiers/Documents/regards_travail/regardstravail-vol05-02.pdf (2) BNQ 9950-099-2010 Consensual Standardization -Policy and Rules of Procedure.Bureau de normalisation du Qubec.(3) CSA-SDP-2.2-98Canadian Standards Association Directives and guidelines governing standardization, Part 2: Development process.
SRT division diagrams and their usage in designing intergrated circuits for division (1986)

This paper describes the construction and analysis of several diagrams which depict SRT division algorithms. These diagrams yield insight into the operation of the algorithms and the many implementation tradeoffs available in custom circuit design. Examples of simple low radix diagrams are shown, as well as tables for higher radices. The tables were generated by a program which can create and verify the diagrams for different division schemes. Also discussed is a custom CMOS integrated circuit designed which performs SRT division using self-timed circuit techniques. This chip implements an intermediate approach between a fully combinational array and a fully iterative in time method in order to get both speed and small silicon area.
Comparative analysis of density based outlier detection techniques on breast cancer data using hadoop and map reduce (2016)

Advancement of technology, has furnished several terabytes of data for companies which can be effectively summed under Data Mining. Finding useful pieces of information from such huge data has been the need of the hour. A term called Anomaly Detection [8] is used in the pretext to refer to data objects which do not confer to a notion of normal data objects. There are various density based clustering algorithms[10] used to categorize data objects as normal or anomalous by finding clusters within the data set. LOF[18] finds the anomalous data objects by finding local density of data objects with respect to local density of its neighbors. DBSCAN finds anomalous data objects by finding data objects surrounded by data objects (density) which are far away from the concerned data object. OPTICS an extension of DBSCAN finds clusters of arbitrary sizes. DENCLUE uses a set of density distribution functions. This paper shows the comparison of the density based algorithms i.e. LOF, OPTICS, DBSCAN, DENCLUE based upon parameters such as time taken on single cluster hadoop, noise accuracy detection level, number of anomalous instances detected on high dimensional data, handle varied density, input parameters and complexity etc.
Multiple-slit streak tube imaging lidar (MS-STIL) applications (2000)

Multiple-Slit Streak Tube Imaging Lidar (MS-STIL) represents a new method for using streak tubes in a laser radar configuration. The MS-STIL approach uses several slits instead of the usual single slit to provide a number of additional capabilities over conventional laser radar systems. System configurations for providing 3D single-laser-pulse scannerless imaging, 3D multispectral imaging, 3D multispectral fluorescence imaging, 3D polarimetry, and combined 3D spectro- polarimeters are presented. In addition, a very high-speed laser diagnostic system capable of measuring laser wavefront changes at GHz rates is discussed.
Galvanic Corrosion of Lead by Iron (Oxyhydr)Oxides: Potential Impacts on Drinking Water Quality (2017)

Lead exposure via drinking water remains a significant public health risk; this study explored the potential effects of upstream iron corrosion on lead mobility in water distribution systems. Specifically, galvanic corrosion of lead by iron (oxyhydr)oxides was investigated. Coupling an iron mineral cathode with metallic lead in a galvanic cell increased lead release by 531 μg L<sup>-1</sup> on average-a 9-fold increase over uniform corrosion in the absence of iron. Cathodes were composed of spark plasma sintered Fe<sub>3</sub>O<sub>4</sub> or α-Fe<sub>2</sub>O<sub>3</sub> or field-extracted Fe<sub>3</sub>O<sub>4</sub> and α-FeOOH. Orthophosphate immobilized oxidized lead as insoluble hydroxypyromorphite, while humic acid enhanced lead mobility. Addition of a humic isolate increased lead release due to uniform corrosion by 81 μg L<sup>-1</sup> and-upon coupling lead to a mineral cathode-release due to galvanic corrosion by 990 μg L<sup>-1</sup>. Elevated lead in the presence of humic acid appeared to be driven by complexation, with <sup>208</sup>Pb and UV<sub>254</sub> size-exclusion chromatograms exhibiting strong correlation under these conditions (R<sup>2</sup><sub>average</sub> = 0.87). A significant iron corrosion effect was consistent with field data: lead levels after lead service line replacement were greater by factors of 2.3-4.7 at sites supplied by unlined cast iron distribution mains compared with the alternative, lined ductile iron.
Effect of Thermal Exposure on the Corrosion Properties of an Al-Mg-Sc Alloy Sheet (2000)

The corrosion behaviour of a scandium containing Al-Mg alloy sheet was investigated performing accelerated corrosion tests. The material was studied in an annealed temper (2h at 350°C) and after additional heat treatments at temperatures ranging from 85 to 150°C for time periods up to 3000h. In the annealed condition, the sheet was resistant against intergranular corrosion and stress corrosion cracking and exhibited a moderate susceptibility to exfoliation corrosion. The corrosion resistance was decreased by thermal exposure at temperatures between 85 and 150°C, as indicated by high mass loss and severe exfoliation corrosion attack observed in the NAMLT test and ASSET test, respectively. When alternately immersed in 3.5% NaCI solution under static loading conditions, the scandium bearing Al-Mg alloy was found to be immune against stress corrosion cracking. For sheet material heat treated in the temperature range from 85 to 150°C, environment-induced failure was observed under the severe loading conditions of the slow strain rate testing technique using an aqueous solution of 3% NaCl + 0.3% H 2 O 2 . The deterioration in corrosion resistance of the Al-Mg-Sc alloy sensitised by thermal exposure was associated with grain boundary precipitation of a magnesium rich phase.
Die kindliche Hüftdysplasie und -luxation – wann und wie operieren? (2008)

Zusammenfassung Die angeborene Hüftdysplasie und -luxation stellt durch die Früherkennungsmaßnahme der Hüftsonografie eine Domäne der konservativen Therapie dar. Dennoch kommen auch im deutschsprachigen Raum unerkannte bzw. zu spät festgestellte Hüftgelenksdysplasien und unzureichend behandelte Luxationen vor. Sie bedürfen wegen des zunehmend geringer werdenden Remodellierungspotenzials in den meisten Fällen einer operativen Korrektur. Die operativen Verfahren lassen sich in gelenkzentrierende und pfannenverbessernde Eingriffe sowie Operationen am proximalen Femurende unterteilen. Jede dieser Maßnahmen hat ihren eigenen Indikationsbereich. In bestimmten Fällen müssen die Techniken kombiniert werden. Die Nachbehandlung erfordert nach einer Ruhigstellungsphase die krankengymnastische Mobilisation, die in speziellen Fällen vorübergehend durch Orthesen ergänzt werden sollte. Die Ergebnisse sind bei korrekter Indikationsstellung und Operationstechnik zuverlässig gut. Seltene postoperative Probleme betreffen die Hüftkopfnekrose, die Restdysplasie, die Reluxation, Bewegungseinschränkungen und Beinverkürzungen, die meistens weitere Operationen erforderlich machen. Trotz der Fortschritte im alloarthroplastischen Ersatz des Erwachsenenhüftgelenkes kommt der Wiederherstellung einer optimalen Hüftgelenkszentrierung des Kindes und Jugendlichen nach wie vor eine herausragende Bedeutung zu.
Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction (2015)

LOX family members contribute significantly to the detrimental effects of cardiac remodelling, highlighting LOX inhibition as a potential therapeutic strategy for post-infarction recovery.
Supplementary Fig. 4 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia (2023)

&lt;p&gt;Dual FLT3/LSD1 inhibition suppresses MYC expression and activity.&lt;/p&gt;
Human HLA-B27 gene enhances susceptibility of rats to oral infection by Listeria monocytogenes. (1996)

Germfree rats transgenic for the human genes HLA-B27 and beta 2-microglobulin were colonized with hemolysin-positive (Hly+) or hemolysin-negative (Hly-) strains of Listeria monocytogenes. HLA-B27 rats were very susceptible to infection with Hly+ L monocytogenes none survived beyond 6 days. Conversely, nontransgenic control rats survived alimentary tract colonization with the Hly+ strain, and both transgenic and nontransgenic rats survived colonization with the Hly- strain of L monocytogenes. After colonization with Hly+ L monocytogenes, both transgenic and nontransgenic rats developed severe bowel inflammation which consisted histologically of microab scesses, granulomatous lesions, and ulcers; however, whereas the transgenic rats died within 6 days, only very mild intestinal lesions were seen in nontransgenic rats 10 to 42 days after colonization. Liver and splenic lesions were small and transient in nontransgenic rats. Transgenic and nontransgenic control rats infected with Hly- Listeria developed mild transient diarrhea but showed no histological changes in the intestine. This study thus documents an association between a particular bacterial product (hemolysin produced by L monocytogenes) and the induction of severe inflammatory disease and death in rats expressing HLA-B27 and beta 2-microglobulin.
MIsoMine: a genome-scale high-resolution data portal of expression, function and networks at the splice isoform level in the mouse (2015)

Products of multiexon genes, especially in higher organisms, are a mixture of isoforms with different or even opposing functions, and therefore need to be treated separately. However, most studies and available resources such as Gene Ontology provide only gene-level function annotations, and therefore lose the differential information at the isoform level. Here we report MIsoMine, a high-resolution portal to multiple levels of functional information of alternatively spliced isoforms in the mouse. This data portal provides tissue-specific expression patterns and co-expression networks, along with such previously published functional genomic data as protein domains, predicted isoform-level functions and functional relationships. The core utility of MIsoMine is allowing users to explore a preprocessed, quality-controlled set of RNA-seq data encompassing diverse tissues and cell lineages. Tissue-specific co-expression networks were established, allowing a 2D ranking of isoforms and tissues by co-expression patterns. The results of the multiple isoforms of the same gene are presented in parallel to facilitate direct comparison, with cross-talking to prioritized functions at the isoform level. MIsoMine provides the first isoform-level resolution effort at genome-scale. We envision that this data portal will be a valuable resource for exploring functional genomic data, and will complement the existing functionalities of the mouse genome informatics database and the gene expression database for the laboratory mouse. Database URL: http://guanlab.ccmb.med.umich.edu/misomine/
INVESTIGATION INTO IDENTIFICATION OF FAULTS IN A SMALL HSDI DIESEL ENGINE USING ACOUSTIC EMISSION (2004)

In this study a method of identifying faults in a small four cylinder, four stroke, normally aspirated HSDI diesel engine, type Lister-Petter 4X90, using acoustic emission (AE) was investigated. The study was confined to injector faults and leakage of the exhaust manifold gasket although the findings could, in principle, be applied to other types of fluid-mechanical malfunction. Simultaneous measurements of AE, cylinder no. 1 pressure and needle lift, crankshaft speed and torque were acquired for a range of speeds and loads. Using features extracted from the raw AE signal, wavelet transformation and statistical techniques it has been shown, that AE can identify these faults over a range of engine operating conditions. The advantage of using AE over more traditional methods is that the non-intrusive nature of the sensors can result in reduced set up times and therefore cost. Engine condition can have a significant effect on combustion quality in a diesel engine which in turn can compromise engine performance. As a result there have been many
An approach to graphics system design (1974)

A discussion of some of the problems that arise in the design of high-level general-purpose device-independent graphics systems is presented. These problems are shown to be most easily solved by avoiding the use of complex display data structures prior to the picture transformation process. The use of a display file containing the transformed picture is proposed instead. This approach restricts the range of display equipment suitable for use as output devices but does not prevent the use of high-performance equipment. The use of a small set of high-level graphic input functions is also suggested and it is shown why this appears to be the best solution to the problem of programming graphic input devices. Included, too, is an outline description of a graphics system designed along the proposed lines.
Proof of concept of a multimodal intravital molecular imaging system for tumour transpathology investigation (2021)

Abstract Background Transpathology highlights the interpretation of the underlying physiology behind molecular imaging. However, it remains challenging due to the discrepancies between in vivo and in vitro measurements and difficulties of precise co-registration between trans-scaled images. This study aims to develop a multimodal intravital molecular imaging (MIMI) system as a tool for in vivo tumour transpathology investigation. Methods The proposed MIMI system integrates high-resolution positron imaging, magnetic resonance imaging (MRI) and microscopic imaging on a dorsal skin window chamber on an athymic nude rat. The window chamber frame was designed to be compatible with multimodal imaging and its fiducial markers were customized for precise physical alignment among modalities. The co-registration accuracy was evaluated based on phantoms with thin catheters. For proof of concept, tumour models of the human colorectal adenocarcinoma cell line HT-29 were imaged. The tissue within the window chamber was sectioned, fixed and haematoxylin–eosin (HE) stained for comparison with multimodal in vivo imaging. Results The final MIMI system had a maximum field of view (FOV) of 18 mm × 18 mm. Using the fiducial markers and the tubing phantom, the co-registration errors are 0.18 ± 0.27 mm between MRI and positron imaging, 0.19 ± 0.22 mm between positron imaging and microscopic imaging and 0.15 ± 0.27 mm between MRI and microscopic imaging. A pilot test demonstrated that the MIMI system provides an integrative visualization of the tumour anatomy, vasculatures and metabolism of the in vivo tumour microenvironment, which was consistent with ex vivo pathology. Conclusions The established multimodal intravital imaging system provided a co-registered in vivo platform for trans-scale and transparent investigation of the underlying pathology behind imaging, which has the potential to enhance the translation of molecular imaging.