gebhart/patrepeval huggingface dataset:
Intrinsic Defects in MoS2 Grown by Pulsed Laser Deposition: From Monolayers to Bilayers (2021)

Pulsed laser deposition (PLD) can be considered a powerful method for the growth of two-dimensional (2D) transition-metal dichalcogenides (TMDs) into van der Waals heterostructures. However, despite significant progress, the defects in 2D TMDs grown by PLD remain largely unknown and yet to be explored. Here, we combine atomic resolution images and first-principles calculations to reveal the atomic structure of defects, grains, and grain boundaries in mono- and bilayer MoS<sub>2</sub> grown by PLD. We find that sulfur vacancies and Mo<sub>S</sub> antisites are the predominant point defects in 2D MoS<sub>2</sub>. We predict that the aforementioned point defects are thermodynamically favorable under a Mo-rich/S-poor environment. The MoS<sub>2</sub> monolayers are polycrystalline and feature nanometer size grains connected by a high density of grain boundaries. In particular, the coalescence of nanometer grains results in the formation of 180° mirror twin boundaries consisting of distinct 4- and 8-membered rings. We show that PLD synthesis of bilayer MoS<sub>2</sub> results in various structural symmetries, including AA' and AB, but also turbostratic with characteristic moiré patterns. Moreover, we report on the experimental demonstration of an electron beam-driven transition between the AB and AA' stacking orientations in bilayer MoS<sub>2</sub>. These results provide a detailed insight into the atomic structure of monolayer MoS<sub>2</sub> and the role of the grain boundaries on the growth of bilayer MoS<sub>2</sub>, which has importance for future applications in optoelectronics.
Effects of erythromycin, clarithromycin, roxithromycin and azithromycin on murine gut colonization byCandida albicans (2002)

Male Crl:CD1(ICR) BR mice were fed either chow containing Candida albicans or regular chow. The gastrointestinal tract of the C. albicans-fed mice was permanently colonized by the yeast. Groups of C. albicans-colonized mice were subsequently treated either with a macrolide (erythromycin, clarithromycin, roxithromycin or azithromycin) for 10 days or a normal saline solution (controls). Other controls included non-colonized mice receiving the same antibiotics or a saline solution. Our data are as follows: (i) C. albicans-colonized mice treated with each macrolide had highly significant increase in colony counts of C. albicans in their stools compared to C. albicans-colonized mice treated with saline only; (ii) discontinuation of macrolide treatment showed a trend towards lower colony counts, which was not statistically significant (colony counts were sustained even after discontinuation of antibiotic treatment); (iii) dissemination of C. albicans did not occur; (iv) mice fed regular chow treated with the study drugs or saline did not have any yeasts in their stools. In conclusion, oral erythromycin, clarithromycin, roxithromycin and azithromycin cause a modest increase of the C. albicans concentration of the gastrointestinal tract. This increase is not associated with a higher risk of disseminated candidiasis.
Applying an optimized switching strategy to a high gain boost converter for input current ripple cancellation (2017)

This paper discusses applying various switching strategies such as conventional complementary and proportional methods on a specific converter. This converter was recently presented and it can provide high voltage gain and has current ripple cancelation ability at a preselected duty-cycle. The input current ripple is zero when the converter works at a special duty-cycle. But load disturbance leads to output voltage changes that maybe cause the duty-cycle to deviate from its preselected value. In this situation, the input current ripple cannot be completely canceled. The proposed proportional strategy is an optimized method for minimizing input current ripple at other operating duty-cycles and also it provides a voltage gain lower than conventional complementary strategy. Here, the converter's performance is analyzed under two switching strategies and the effect of various strategies has been investigated on converter parameters including output voltage and input current ripple. These considerations are verified by implementing a 100-W prototype of the proposed converter in laboratory.
Ontology-based multimedia contents retrieval framework in smart TV environment (2013)

Semantic search promises to provide more accurate result than present-day keyword matching-based search by using the knowledge represented logically (i.e., knowledge base). But, the ordinary users don't know well the complex formal query language and schema of the knowledge base. So, the system should interpret the meaning of user's keywords. Such requirements are conspicuous especially in smart media such as smart phone, IPTV and smart TV. In this paper, we describe a framework for the semantic retrieval of multimedia contents. Our framework is ontological knowledge base-driven in the sense that the interpretation process is integrated into a unified structure around a knowledge base, which is built on domain ontologies. Our framework also integrates such components as for knowledge base augmentation by user preference and context. We also present our prototype system we have been developing to test our framework ideas.
High Performance 0.1um CMOS Device with Suppressed Parasitic Junction Capacitance and Junction Leakage Current (2002)

High performance 0.1μm MOSFETs with a 70nm physical gate length and 1.7nm gate oxide thickness are demonstrated. By reducing the parasitic junction capacitance and suppressing the junction leakage current (Ileak,j), high speed/low power transistors are fabricated with a superior driving current. Careful optimization in channel, pocket and source/drain (S/D) doping profile results in a reduction of N+/PW area junction capacitance (Cja) to 0.8fF/μm and P+/NW Cja to 0.7fF/μm. In addition, area diode leakage current (Ileak,a) <50nA/cm2 and periphery diode leakage current (Ileak,p) <0.1fA/μm are achieved. In this work, NMOS drive current and PMOS drive current are 840μA/μm and 380μA/μm respectively, at 1.2V with an off-state current (Ioff) 15nA/μm. With the reduced parasitic capacitance and the high driving current, the unloaded ring oscillator has 10.5ps/stage at 1.2V operation.
The American College of Rheumatology Provisional Composite Response Index for Clinical Trials in Early Diffuse Cutaneous Systemic Sclerosis (2016)

We have developed a CRISS that is appropriate for use as an outcome assessment in RCTs of early dcSSc.
BRAIN SWELLING DUE TO EXPERIMENTAL CEREBRAL INFARCTION: CHANGES IN VASOMOTOR CAPACITANCE AND EFFECTS OF INTRAVENOUS GLYCEROL (1972)

Journal Article BRAIN SWELLING DUE TO EXPERIMENTAL CEREBRAL INFARCTION: CHANGES IN VASOMOTOR CAPACITANCE AND EFFECTS OF INTRAVENOUS GLYCEROL Get access JOHN STIRLING MEYER, JOHN STIRLING MEYER Department of Neurology, Baylor College of Medicine, and the Baylor-Methodist Center for Cerebrovascular ResearchHouston, Texas, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar TETSUAKI TERAURA, TETSUAKI TERAURA Department of Neurology, Baylor College of Medicine, and the Baylor-Methodist Center for Cerebrovascular ResearchHouston, Texas, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar PETER MARX, PETER MARX Department of Neurology, Baylor College of Medicine, and the Baylor-Methodist Center for Cerebrovascular ResearchHouston, Texas, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar KAZUO HASHI, KAZUO HASHI Department of Neurology, Baylor College of Medicine, and the Baylor-Methodist Center for Cerebrovascular ResearchHouston, Texas, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar KEIZO SAKAMOTO KEIZO SAKAMOTO Department of Neurology, Baylor College of Medicine, and the Baylor-Methodist Center for Cerebrovascular ResearchHouston, Texas, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Brain, Volume 95, Issue 4, 1972, Pages 833–852, https://doi.org/10.1093/brain/95.4.833 Published: 01 January 1972 Article history Published: 01 January 1972 Received: 26 January 1972
Overlooking Evolution: A Systematic Analysis of Cancer Relapse and Therapeutic Resistance Research (2011)

Cancer therapy selects for cancer cells resistant to treatment, a process that is fundamentally evolutionary. To what extent, however, is the evolutionary perspective employed in research on therapeutic resistance and relapse? We analyzed 6,228 papers on therapeutic resistance and/or relapse in cancers and found that the use of evolution terms in abstracts has remained at about 1% since the 1980s. However, detailed coding of 22 recent papers revealed a higher proportion of papers using evolutionary methods or evolutionary theory, although this number is still less than 10%. Despite the fact that relapse and therapeutic resistance is essentially an evolutionary process, it appears that this framework has not permeated research. This represents an unrealized opportunity for advances in research on therapeutic resistance.
Influence of repeated exposure of male rats to oestrous odour on their subsequent sexual behaviour. (1984)

Adult and sexually naive male rats were individually, in repeated sessions, put into a box the floor of which had beforehand been scent-marked by oestrous females. The males of the control group were put into a box which had not been scent-marked. Although the males exposed to scent-marks showed, in two performed tests, significantly more precopulatory activities towards the passively receptive female, they were not able to initiating copulation with her. They initiated copulatory behaviour only in the test when their partner was a female exhibiting ritualized dartings.
A recurrent magnesium-binding motif provides a framework for the ribosomal peptidyl transferase center (2009)

The ribosome is an ancient macromolecular machine responsible for the synthesis of all proteins in all living organisms. Here we demonstrate that the ribosomal peptidyl transferase center (PTC) is supported by a framework of magnesium microclusters (Mg(2+)-muc's). Common features of Mg(2+)-muc's include two paired Mg(2+) ions that are chelated by a common bridging phosphate group in the form Mg((a))(2+)-(O1P-P-O2P)-Mg((b))(2+). This bridging phosphate is part of a 10-membered chelation ring in the form Mg((a))(2+)-(OP-P-O5'-C5'-C4'-C3'-O3'-P-OP)-Mg((a))(2+). The two phosphate groups of this 10-membered ring are contributed by adjacent residues along the RNA backbone. Both Mg(2+) ions are octahedrally coordinated, but are substantially dehydrated by interactions with additional RNA phosphate groups. The Mg(2+)-muc's in the LSU (large subunit) appear to be highly conserved over evolution, since they are unchanged in bacteria (Thermus thermophilus, PDB entry 2J01) and archaea (Haloarcula marismortui, PDB entry 1JJ2). The 2D elements of the 23S rRNA that are linked by Mg(2+)-muc's are conserved between the rRNAs of bacteria, archaea and eukarya and in mitochondrial rRNA, and in a proposed minimal 23S-rRNA. We observe Mg(2+)-muc's in other rRNAs including the bacterial 16S rRNA, and the P4-P6 domain of the tetrahymena Group I intron ribozyme. It appears that Mg(2+)-muc's are a primeval motif, with pivotal roles in RNA folding, function and evolution.
Direct and highly productive conversion of cyanobacteria Arthrospira platensis to ethanol with CaCl2 addition (2018)

We developed an ethanol conversion process using a recombinant amylase-expressing yeast from <i>A. platensis</i> with a high titer, yield, and productivity by adding both lysozyme and CaCl<sub>2</sub>. The direct and highly productive conversion process from <i>A. platensis</i> via yeast fermentation could be applied to multiple industrial bulk chemicals.
A New Internal Mammary Artery Retractor (1990)

A new retractor for asymmetric opening of the chest is presented. The instrument is mainly used for dissection of the internal mammary artery, but other applications are possible such as resection of large mediastinal tumors, or pulmonary resections through median sternotomy. The device is comprised of a standard retractor combined with a tilting mechanism which lifts one side of the chest (following median sternotomy) while depressing the other side, resulting in an asymmetric opening of the thoracic cavity. The retractor has been used routinely since late 1987. As of April 1990 it has been employed in more than 3000 operations, and has appeared to be safe and efficient.
Model structure learning: A support vector machine approach for LPV linear-regression models (2011)

Accurate parametric identification of Linear Parameter-Varying (LPV) systems requires an optimal prior selection of a set of functional dependencies for the parametrization of the model coefficients. Inaccurate selection leads to structural bias while over-parametrization results in a variance increase of the estimates. This corresponds to the classical bias-variance trade-off, but with a significantly larger degree of freedom and sensitivity in the LPV case. Hence, it is attractive to estimate the underlying model structure of LPV systems based on measured data, i.e., to learn the underlying dependencies of the model coefficients together with model orders etc. In this paper a Least-Squares Support Vector Machine (LS-SVM) approach is introduced which is capable of reconstructing the dependency structure for linear regression based LPV models even in case of rational dynamic dependency. The properties of the approach are analyzed in the prediction error setting and its performance is evaluated on representative examples.
Modellgetriebene Entwicklung serviceorientierter Anlagensteuerungen (2017)

Zusammenfassung Serviceorientierte Architekturen ermöglichen flexible Steuerungsstrukturen. Allerdings steigt dadurch die Komplexität beim Engineering der Komponenten des Steuerungsnetzwerks. Im Rahmen dieser Veröffentlichung wird aufgezeigt, dass eine modellgetriebene Entwicklung kombiniert mit einer wiederverwendbaren, modular-aufgebauten Systemsoftware den Umgang mit Komplexität beim Engineering vereinfachen kann.
Method and apparatus for removing heat from electronic devices using synthetic jets (2023)

An apparatus for removing heat comprises a heat sink having a cavity, and a synthetic jet stack comprising at least one synthetic jet mounted within the cavity. At least one rod and at least one engaging structure to provide a rigid positioning of the at least one synthetic jet with respect to the at least one rod. The synthetic jet comprises at least one orifice through which a fluid is ejected.
Synthesis, antimicrobial evaluation, QSAR and in Silico ADMET studies of decanoic acid derivatives. (2011)

Various derivatives of decanoic acid (CD) have been synthesized and evaluated against Gram positive B. subtilis, S. aureus and Gram negative E. coli bacteria as well a sagainst fungi C. albicans and A. niger. Quantitative structure activity relationship (QSAR) models for antimicrobial activities were developed using multiple linear regression and cross validated by leave one out (LOO) approach. QSAR studies indicated that activity against Gram positive bacteria was governed by lipophilicity of the compounds while topologicalsteric nature of the molecule was deciding factor for antifungal activity. Further, in silico ADMET studies showed that compounds CD12, 19, 20 and 23 could be explored further for other activities.
Supplementary Table 5 from Transcriptome-Wide Association Study Identifies New Candidate Susceptibility Genes for Glioma (2023)

&lt;p&gt;Supplementary Table 5: Table of module color with module size and associated Z-statistics. Modules were created by clustering according to the Amygdala tissue using WGCNA11. These modules of gene number "moduleSize" were applied to each tissue in turn and the Z-statistic ("Zsummary.pres") is a quantitive measure of module preservation relative to Amygdala. (a) Anterior cingulate cortex (BA24); (b) Caudate (basal ganglia); (c) Cerebellar Hemisphere; (d) Cerebellum; (e) Cortex; (f) Frontal Cortex (BA9); (g) Hippocampus; (h) Hypothalamus; (i) Nucleus accumbens (basal ganglia); (j) Putamen (basal ganglia); (k) Spinal cord (cervical c-1); (l) Substantia nigra.&lt;/p&gt;
A Case for Variability-Aware Policies for NISQ-Era Quantum Computers (2018)

Recently, IBM, Google, and Intel showcased quantum computers ranging from 49 to 72 qubits. While these systems represent a significant milestone in the advancement of quantum computing, existing and near-term quantum computers are not yet large enough to fully support quantum error-correction. Such systems with few tens to few hundreds of qubits are termed as Noisy Intermediate Scale Quantum computers (NISQ), and these systems can provide benefits for a class of quantum algorithms. In this paper, we study the problems of Qubit-Allocation (mapping of program qubits to machine qubits) and Qubit-Movement(routing qubits from one location to another to perform entanglement). We observe that there exists variation in the error rates of different qubits and links, which can have an impact on the decisions for qubit movement and qubit allocation. We analyze characterization data for the IBM-Q20 quantum computer gathered over 52 days to understand and quantify the variation in the error-rates and find that there is indeed significant variability in the error rates of the qubits and the links connecting them. We define reliability metrics for NISQ computers and show that the device variability has the substantial impact on the overall system reliability. To exploit the variability in error rate, we propose Variation-Aware Qubit Movement (VQM) and Variation-Aware Qubit Allocation (VQA), policies that optimize the movement and allocation of qubits to avoid the weaker qubits and links and guide more operations towards the stronger qubits and links. We show that our Variation-Aware policies improve the reliability of the NISQ system up to 2.5x.
Map Building Using Cheap Digital Cameras (2007)

Cheap digital cameras are readily available. They can be mounted on robots and used to build maps of the surrounding environment. However, these cameras suffer from several drawbacks such as a narrow field of view, low resolution and limited range due to perspective. These limitations can cause traditional approaches to Simultaneous Localization and Mapping to fail due to insufficient information content in the visual sensor data. This paper discusses these issues and presents a solution for indoor environments.
Data from Histone Deacetylase Cytoplasmic Trapping by a Novel Fluorescent HDAC Inhibitor (2023)

&lt;div&gt;Abstract&lt;p&gt;Inhibitors of histone deacetylases (HDAC) are an important emerging class of drugs for the treatment of cancers. HDAC inhibitors are currently under evaluation in clinical trials as single agents and as sensitizers in combinations with chemotherapies and radiation therapy. Although these drugs have important effects on cancer cell growth and functions, the mechanisms underlying HDAC inhibitor activities remain to be fully defined. By using rational drug design, compound 2, a fluorescent class II HDAC targeting inhibitor, was synthesized and observed to accumulate in the cytoplasmic compartments of treated cells, but not in the nuclei. Furthermore, immunostaining of inhibitor exposed cells for HDAC4 showed accumulation of this enzyme in the cytoplasmic compartment with concomitant increased acetylation of tubulin and nuclear histones. These observations support a mechanism by which nuclear histone acetylation is increased as a result of HDAC4 trapping and sequestration in the cytoplasm after binding to compound 2. The HDAC inhibitor offers potential as a novel theranostic agent, combining diagnostic and therapeutic properties in the same molecule. &lt;i&gt;Mol Cancer Ther; 10(9); 1591–9. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Urinary Fibrin/Fibrinogen Derivatives (1975)

* Presented at the Postgraduate Course and Workshop “Progress in Fibrinolysis”, Milano, Italy, March 6–8, 1975.
The Protein-tyrosine Phosphatase SHP-2 Is Required during Angiotensin II-mediated Activation of Cyclin D1 Promoter in CHO-AT1A Cells (2000)

Angiotensin II (Ang II) binds to specific G protein-coupled receptors and is mitogenic in Chinese hamster ovary (CHO) cells stably expressing a rat vascular angiotensin II type 1A receptor (CHO-AT(1A)). Cyclin D1 protein expression is regulated by mitogens, and its assembly with the cyclin-dependent kinases induces phosphorylation of the retinoblastoma protein pRb, a critical step in G(1) to S phase cell cycle progression contributing to the proliferative responses. In the present study, we found that in CHO-AT(1A) cells, Ang II induced a rapid and reversible tyrosine phosphorylation of various intracellular proteins including the protein-tyrosine phosphatase SHP-2. Ang II also induced cyclin D1 protein expression in a phosphatidylinositol 3-kinase and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK)-dependent manner. Using a pharmacological and a co-transfection approach, we found that p21(ras), Raf-1, phosphatidylinositol 3-kinase and also the catalytic activity of SHP-2 and its Src homology 2 domains are required for cyclin D1 promoter/reporter gene activation by Ang II through the regulation of MAPK/ERK activity. Our findings suggest for the first time that SHP-2 could play an important role in the regulation of a gene involved in the control of cell cycle progression resulting from stimulation of a G protein-coupled receptor independently of epidermal growth factor receptor transactivation.
Controllable Synthesis of Pure-Phase Rare-Earth Orthoferrites Hollow Spheres with a Porous Shell and Their Catalytic Performance for the CO + NO Reaction (2010)

Pure perovskite LnFeO3 (Ln = La, Pr−Tb) hollow spheres with porous shell and solid spheres (Ln = Dy−Yb, Y) have been successfully synthesized via calcination of a Ln-Fe citrate complex precursor, which was prepared via a convenient and effective hydrothermal method. The reaction parameters to obtain the Ln-Fe citrate complex with Ln/Fe = 1:1 can be calculated using a diagram of reaction species distribution in the solution. The calculated value was coincident well with the experimental one. The composition and the thermal decomposition processes of the Ln-Fe citrate complex were investigated carefully, using elemental analysis, inductively coupled plasma analysis (ICP), energy-dispersive spectroscopy (EDS), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). The formation mechanism of the Ln-Fe citrate complex hollow spheres was proposed as an acidic digestion ripening process. Furthermore, all 13 pure-phase LnFeO3 microspheres had an excellent catalytic performance for the NO + CO reaction. The experimental results showed that the completed conversion of NO and specific selectivity of N2 were achieved, which could be comparable with the noble metal catalysts and better than that of LnFeO3 nanoparticles synthesized via the Pechini process. In addition, the LnFeO3 microspheres exhibited good chemical stability and almost invariable catalytic activity during the lifetime test lasting for 96 h.