gebhart/patrepeval huggingface dataset:
Data from Clinical Pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Tisagenlecleucel is an anti-CD19 chimeric antigen receptor (CAR19) T-cell therapy approved for the treatment of children and young adults with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL).&lt;/p&gt;Patients and Methods:&lt;p&gt;We evaluated the cellular kinetics of tisagenlecleucel, the effect of patient factors, humoral immunogenicity, and manufacturing attributes on its kinetics, and exposure-response analysis for efficacy, safety and pharmacodynamic endpoints in 79 patients across two studies in pediatric B-ALL (ELIANA and ENSIGN).&lt;/p&gt;Results:&lt;p&gt;Using quantitative polymerase chain reaction to quantify levels of tisagenlecleucel transgene, responders (&lt;i&gt;N&lt;/i&gt; = 62) had ≈2-fold higher tisagenlecleucel expansion in peripheral blood than nonresponders (&lt;i&gt;N&lt;/i&gt; = 8; 74% and 104% higher geometric mean Cmax and AUC0-28d, respectively) with persistence measurable beyond 2 years in responding patients. Cmax increased with occurrence and severity of cytokine release syndrome (CRS). Tisagenlecleucel continued to expand and persist following tocilizumab, used to manage CRS. Patients with B-cell recovery within 6 months had earlier loss of the transgene compared with patients with sustained clinical response. Clinical responses were seen across the entire dose range evaluated (patients ≤50 kg: 0.2 to 5.0 × 10&lt;sup&gt;6&lt;/sup&gt;/kg; patients &gt;50 kg: 0.1 to 2.5 × 10&lt;sup&gt;8&lt;/sup&gt; CAR-positive viable T cells) with no relationship between dose and safety. Neither preexisting nor treatment-induced antimurine CAR19 antibodies affected the persistence or clinical response.&lt;/p&gt;Conclusions:&lt;p&gt;Response to tisagenlecleucel was associated with increased expansion across a wide dose range. These results highlight the importance of cellular kinetics in understanding determinants of response to chimeric antigen receptor T-cell therapy.&lt;/p&gt;&lt;/div&gt;
A Fiber-Optic-Based Protocol for Manufacturing System Networks: Part II—Statistical Analysis (1992)

Conceptual development, architecture, statistical and simulation models, and the results of test and verification of a fiber-optic-based protocol have been reported in a sequence of two papers. The protocol uses the unidirectional bus topology and is specifically designed for computer integrated manufacturing (CIM) networks. The architecture of the protocol is formulated in Part I [1]. In this second part, a statistical model of the proposed protocol is formulated for analyzing the network-induced delays and pertinent results of analysis and simulation are presented for different scenarios of network traffic. The major assumptions in formulating the statistical model are: (1) message arrival processes for real-time (RT) and non-real-time (NRT) modes are independent and Markov; and (2) message lengths follow independent general distributions with known statistical properties. The Laplace-Stieltjes transforms of probability distribution functions of queueing delays for RT and NRT messages have been derived. The analytical results for the first two moments of both RT and NRT queueing delays have been compared with those obtained from discrete event simulation.
Novel methodology for the evaluation of symptoms reported by patients with newly diagnosed atrial fibrillation: Application of natural language processing to electronic medical records data (2022)

This study illustrates that NLP can be applied to EMR data to characterize symptom reports in patients with incident AF, and the potential for these methods to inform comparative effectiveness.
Magnetic properties of Fe-rich rare-earth intermetallic compounds with a ThMn12 structure (1988)

Sm(Fe1−xMx)12 ternary compounds based on the tetragonal ThMn12 structure where M is Ti, Si, V, Cr, and Mo were investigated. M atoms have a preference for site occupation. Ti atoms occupy the 8i or 8j site and Cr atoms occupy the 8i site. Curie temperatures on Sm(M,Fe)12 compounds are around 590 K except for the SmMo2Fe10 compound (Tc=483 K). The SmTiFe11 and SmSi2Fe10 compounds have a high saturation magnetization and magnetic anisotropy.
Segmenting merged characters (2003)

In optical character recognition (OCR) and document analysis many errors are not caused by inadequate classifier power, but by segmentation errors. Besides broken characters, merged characters constitute the major remaining problem. This paper presents an efficient method for segmenting merged characters. The algorithm combines a statistical adapted cut classifier and a search algorithm, which employs further experts for selecting the proper cut positions from a set of hypotheses. It is designed especially for proportional fonts and even succeeds, if the characters are in italics font style.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Woodworking For Kids: 40 Fabulous, Fun & Useful Things for Kids to Make (1994)

Introduces the tools and techniques of woodworking and provides instructions for various projects.
Isolation of hepatocytes from livers from non-heart-beating donors for cell transplantation (2006)

One of the limitations to hepatocyte transplantation is the restricted availability of donor liver tissue. The aim of this study was to evaluate livers from non-heart-beating donors (NHBDs) as a source of hepatocytes for cell transplantation. A total of 20 livers/segments obtained from NHBD were perfused under good manufacturing practices using a standard collagenase digestion method. The donor liver median warm ischemia time was 15 minutes (range, 11-40 minutes), and cold ischemia time was 13 hours (range, 6-30 hours) prior to cell isolation. The cell viability of the hepatocytes obtained was 52% (1-81%), with a yield of 2.2 x 10(6)(0.2-29.7 x 10(6)) cells per gram of tissue. There was a significant negative correlation between hepatocyte viability and length of both warm ischemia (r = -0.544, P = 0.013) and cold ischemia (r = -0.510, P = 0.022). Preliminary experiments were performed on the viability testing of NHBD livers based on digestion of needle biopsies with collagenase and assessment of the hepatocytes produced. Two of the NHBD cell preparations, which had been cryopreserved, were used as part of a series of cell infusions for hepatocyte transplantation. A 3.5-yr-old girl with Crigler-Najjar syndrome type I received 9.7 x 10(8) NHBD hepatocytes (viability on thawing, 65%), and a 4-month-old boy with inherited clotting factor VII deficiency received 5.0 x 10(8) hepatocytes (viability, 57%). In conclusion, hepatocytes suitable for cell transplantation can be obtained from NHBD livers. Higher viability values may be obtained if both warm and cold ischemia times of donor liver can be reduced prior to processing.
Mass Spectra of Tobacco Alkaloid - Derived Nitrosamines, their Metabolites, and Related Compounds (1981)

Abstract The mass spectra of the tobacco alkaloid - derived nitrosamines NNN, NNK, NNA, NAB and NAtB and of known mammalian metabolites of NNN and NNK are presented. Mass spectra of synthetic derivatives related to these nitrosamines and their metabolites are also included. These spectra will be useful in studies on the occurrence and metabolism of the tobacco alkaloid - derived nitrosamines and in investigations of other compounds related to the tobacco alkaloids.
News at Six: Hepatitis C Special (2014)

This Bristol Myers Squibb-sponsored symposium was chaired by Mark Thursz, who oversaw a novel news bulletin-themed symposium with sessions provided by a distinguished, international team of roving reporters; Charles Gore from the World Hepatitis Alliance, Jean-Michel Pawlotsky from France, Alessandra Mangia from Italy, Ashley Brown and Graham Foster from London, Heiner Wedemeyer from Germany, and Rafael Esteban from Spain.
Modelling brain development to detect white matter injury in term and preterm born neonates (2019)

Premature birth occurs during a period of rapid brain growth. In this context, interpreting clinical neuroimaging can be complicated by the typical changes in brain contrast, size and gyrification occurring in the background to any pathology. To model and describe this evolving background in brain shape and contrast, we used a Bayesian regression technique, Gaussian process regression, adapted to multiple correlated outputs. Using MRI, we simultaneously estimated brain tissue intensity on T1- and T2-weighted scans as well as local tissue shape in a large cohort of 408 neonates scanned cross-sectionally across the perinatal period. The resulting model provided a continuous estimate of brain shape and intensity, appropriate to age at scan, degree of prematurity and sex. Next, we investigated the clinical utility of this model to detect focal white matter injury. In individual neonates, we calculated deviations of a neonate's observed MRI from that predicted by the model to detect punctate white matter lesions with very good accuracy (area under the curve > 0.95). To investigate longitudinal consistency of the model, we calculated model deviations in 46 neonates who were scanned on a second occasion. These infants' voxelwise deviations from the model could be used to identify them from the other 408 images in 83% (T2-weighted) and 76% (T1-weighted) of cases, indicating an anatomical fingerprint. Our approach provides accurate estimates of non-linear changes in brain tissue intensity and shape with clear potential for radiological use.
Spin- and Energy-Dependent Tunneling through a Single Molecule with Intramolecular Spatial Resolution (2010)

We investigate the spin- and energy-dependent tunneling through a single organic molecule (CoPc) adsorbed on a ferromagnetic Fe thin film, spatially resolved by low-temperature spin-polarized scanning tunneling microscopy. Interestingly, the metal ion as well as the organic ligand show a significant spin dependence of tunneling current flow. State-of-the-art ab initio calculations including also van der Waals interactions reveal a strong hybridization of molecular orbitals and substrate $3d$ states. The molecule is anionic due to a transfer of one electron, resulting in a nonmagnetic ($S=0$) state. Nevertheless, tunneling through the molecule exhibits a pronounced spin dependence due to spin-split molecule-surface hybrid states.
A New Computer-Aided Method for Sequencing a Polypeptide from the Masses and Edman-Degradation of its Constituent Peptide Fragments (1982)

Recently Edman degradation [1] has been greatly improved and refined for determination of the amino acid sequences of peptides and proteins in subnanomolar quantities, particularly by use of an improved automated sequencer [2]. However, the method generally requires the purification of peptide mixtures generated from the polypeptide or protein to be sequenced. During the past 3 years, we elaborated a method [3,4] for sequencing peptide mixtures, that does not require their purification, by a combination of field- desorption mass spectrometry (FD-MS) and Edman degradation, because the separation and purification of peptide mixtures are still time consuming and tedious procedures.
Near Net-Shape Ultra-High Melting Recession-Resistant Rocket Nozzles II: Low Cost Carbon-Carbon Technology for Use in Ultra-High Temperature Oxidative Environments (2003)

Abstract : Carbon-carbon composites are ideal materials for high temperature structural uses, such as in rocket propulsion components, hypersonic vehicles, and aircraft brakes. In spite of their excellent properties, the use of carbon-carbon composites has been limited because of their high cost and rapid oxidation at elevated temperatures. Two novel approaches to solving these problems are described and these approaches are employed along with a ZrC/W-based nozzle insert to fabricate and test a recession-resistant carbon-carbon rocket nozzle as a potential replacement for solid tungsten nozzles.
Surface Modification of Fibers via Graft-Site Amplifying Polymers (2003)

The surface properties of fibers play critical roles in many applications such as wicking, soil resistance, adhesion, and bio-compatibility. This paper will discuss a new approach to surface modification in which polymers are grafted to naturally occurring graft-sites on the substrate. The surface modifying polymers contain a large number of new graft-sites, thus amplifying the potential graft-sites up to several thousand-fold. Subsequent modification of the graft-site amplifying polymer can be used to alter the surface charge, wettability, and dye-uptake. Critical features of this technology will be presented along with specific examples.
Long-term intensive endurance exercise training is associated to reduced markers of cellular senescence in the colon mucosa of older adults (2023)

Regular endurance exercise training is an effective intervention for the maintenance of metabolic health and the prevention of many age-associated chronic diseases. Several metabolic and inflammatory factors are involved in the health-promoting effects of exercise training, but regulatory mechanisms remain poorly understood. Cellular senescence-a state of irreversible growth arrest-is considered a basic mechanism of aging. Senescent cells accumulate over time and promote a variety of age-related pathologies from neurodegenerative disorders to cancer. Whether long-term intensive exercise training affect the accumulation of age-associated cellular senescence is still unclear. Here, we show that the classical senescence markers p16 and IL-6 were markedly higher in the colon mucosa of middle-aged and older overweight adults than in young sedentary individuals, but this upregulation was significantly blunted in age-matched endurance runners. Interestingly, we observe a linear correlation between the level of p16 and the triglycerides to HDL ratio, a marker of colon adenoma risk and cardiometabolic dysfunction. Our data suggest that chronic high-volume high-intensity endurance exercise can play a role in preventing the accumulation of senescent cells in cancer-prone tissues like colon mucosa with age. Future studies are warranted to elucidate if other tissues are also affected, and what are the molecular and cellular mechanisms that mediate the senopreventative effects of different forms of exercise training.
Regulation of intracellular pH in alveolar epithelial cells (1992)

Alveolar type II epithelial cells in adult mammalian lungs actively transport salt and water, secrete surfactant, and differentiate into type I cells under normal conditions and following lung injury. It has become increasingly apparent that, like all epithelial cells, alveolar pneumocytes have evolved specialized ion transport mechanisms by which they regulate their intracellular pH (pHi). pHi is an important biological parameter in all living cells whose regulation is necessary for normal cellular homeostasis. pHi, and the ion transport mechanisms by which it is regulated, may contribute to many cellular processes, including transcellular transport, cell volume and osmolarity regulation, and intracellular transport, cell volume and osmolarity regulation, and intracellular electrolyte composition. Moreover, changes in pHi may serve as intracellular signals for biological processes such as cell growth, proliferation, and differentiation. We review herein the general principles of pHi regulation in epithelia and describe the mechanisms and effects of pHi regulation in alveolar pneumocytes. Many of the critical issues in current pulmonary research involve processes that pHi is most likely to affect, including maintenance of alveolar epithelial barrier integrity, development and maintenance of epithelial polarity, epithelial proliferation and differentiation, and regulation of transepithelial transport with respect to alveolar fluid balance in normal individuals and in those with excess alveolar fluid (i.e., pulmonary edema). Investigations into the regulation of pHi in alveolar pneumocytes and the regulatory effects of pHi in turn on other cellular processes are likely to yield information important to the understanding of lung biology and pulmonary disease.
Diffraction-Aware Sound Localization for a Non-Line-of-Sight Source (2019)

We present a novel sound localization algorithm for a non-line-of-sight (NLOS) sound source in indoor environments. Our approach exploits the diffraction properties of sound waves as they bend around a barrier or an obstacle in the scene. We combine a ray tracing-based sound propagation algorithm with a Uniform Theory of Diffraction (UTD) model, which simulate bending effects by placing a virtual sound source on a wedge in the environment. We precompute the wedges of a reconstructed mesh of an indoor scene and use them to generate diffraction acoustic rays to localize the 3D position of the source. Our method identifies the convergence region of those generated acoustic rays as the estimated source position based on a particle filter. We have evaluated our algorithm in multiple scenarios consisting of static and dynamic NLOS sound sources. In our tested cases, our approach can localize a source position with an average accuracy error of 0.7m, measured by the L2 distance between estimated and actual source locations in a 7m×7m×3m room. Furthermore, we observe 37% to 130% improvement in accuracy over a state-of-the-art localization method that does not model diffraction effects, especially when a sound source is not visible to the robot.
Enhanced Resolution for Closely-Spaced Objects From Optical Sensor Using FPA Offset (2022)

The problem of measurement extraction for two point targets in the focal plane array (FPA) of an optical sensor has been investigated in (Finelli et al., 2021) and (Lu et al., 2019). However, when the separation between the two targets is too small, they become unresolved—they yield a single unresolved merged measurement. This article presents an effective way to enhance the resolution for two such closely-spaced objects. One frame has the original image of the two targets, while a second frame has the FPA slightly shifted by a fraction of a pixel (called offset frame). The measurement extraction consists of two parts: estimation and detection. First, the targets' positions and intensities are jointly estimated based on the two frames' measurements (the original frame and the offset frame) under the resolved and unresolved target assumptions. The Cramer–Rao lower bound evaluates the estimation accuracy. Second, a hypothesis test is used to decide whether the two targets can be resolved or are unresolved. The generalized likelihood ratio test is used to perform decision making. Simulations investigate the effect of offset types, target separation, and signal-to-noise ratio on the measurement extraction and resolution. It is shown that adding offset to the image can provide more information about the closely-spaced objects, and offset enhances the resolution probability when compared to the two frames without offset.
Backward second-harmonic generation in periodically poled bulk LiNbO_3 (1997)

We experimentally demonstrate backward second-harmonic generation in periodically poled LiNbO(3) with a 3.3- microm domain period. We observed higher-order phase matching near 1490, 1600, and 1700 nm (fundamental) for the 19th, 18th, and 17th orders, respectively, with a maximum conversion efficiency of 0.02%.
Efficient frequency domain selective scrambling of digital video (2003)

Multimedia data security is very important for multimedia commerce on the Internet such as video-on-demand and real-time video multicast. Traditional cryptographic algorithms/systems for data security are often not fast enough to process the vast amount of data generated by multimedia applications to meet real-time constraints. This paper presents a joint encryption and compression framework in which video data are scrambled efficiently in the frequency domain by employing selective bit scrambling, block shuffling and block rotation of the transform coefficients and motion vectors. The new approach is very simple to implement, yet provides considerable levels of security and different levels of transparency, and has a very limited adverse impact on compression efficiency and no adverse impact on error resiliency. Furthermore, it allows transcodability/scalability, and other content processing functionalities without having to access the cryptographic key and perform decryption and re-encryption.
A General, Neutral Beckmann Rearrangement of Ketoximes. The Isolation of an Intermediate (1974)

Abstract A short time ago1 we reported that treatment of (EJ or (3-aldoximes with 1, l'-carbonyldiimidazole yielded the corresponding nitrile, Co2 and imidazole.
X-ray absorption spectroscopy of silicates for in situ, sub-micrometer mineral identification (2003)

We present X-ray absorption near-edge structure (XANES) spectroscopy of 11 silicate and aluminosilicate minerals and two glasses at the SiK and SiL2,3, and OK edges. The similar nearestneighbor environments lead to similar spectral lineshapes at each edge, but the fine-structure differences allow individual and groups of structurally similar minerals to be distinguished. By combining spectra and their first energy derivative from three absorption edges, we show that every mineral studied is distinguishable with XANES. This background work, combined with X-ray PhotoElectron Emission spectroMicroscopy (X-PEEM), allows non-destructive in situ, sub-micrometer (to 35 nm) X-ray analysis of materials, including silicate inclusions, which has not been possible previously. Images and spectra from a 7 μm × 3.5 μm quartz inclusion in zircon are presented as a test of this novel technique in geology.
Spinal cord potentials evoked by cutaneous afferents in the monkey (1977)

1. Negative intermediary cord potentials and the equivalent field potentials were recorded from the surface or within the monkey lumbosacral spinal cord in response to stimulation of myelinated afferent fibers in cutaneous or mixed nerves of the hindlimb. 2. Cord potentials resembling the N1 and N2 potentials described in the cat spinal cord were found but, in addition, activation of small myelinated fibers produced a later potential named here the N3-wave. By use of a subtraction technique, it is estimated that the N3-wave has a latency of 11.4 (+/- 3.5 SD) ms from the time of arrival of the volley in the largest affs at 9 (+/- 3) ms after its onset, and the wave lasts 23 (+/- 5.7) ms. 3. The N3-wave is not lost following spinal cord transection, but may instead be enhanced. It is thus due to neural circuitry intrinsic to the lumbosacral spinal cord. 4. The longitudinal distribution of the N3-wave is similar to that of the N1- and N2-waves. 5. The field potential associated with the N3-wave and recorded from within the spinal cord has two negative foci in some animals: near the dorsalmost part of the dorsal horn and in an area equivalent to Rexed's laminae IV-VI. The field potential reverses in sign in the ventral horn. 6. The N3-wave is evoked by Adelta fibers. This was shown by grading the stimulus strength, by measuring the conduction delay for producing the wave when stimuli are applied either proximally or distally on the sural nerve, and by showing that the N3-wave persists when the Aalphabeta fibers are anodally blocked. 7. There is often a late burst discharge in spinal neurons, including spinothalamic tract neurons, which can be attributed to Adelta fibers and which corresponds in time to the N3-wave. 8. It is proposed that the N3-wave can be used as a monitor of the central effects of Adelta fibers in the spinal cord.