gebhart/patrepeval huggingface dataset:
Abstract P321: Substance P is Associated with Hypertension-induced Cardiac Fibrosis (2018)

Myocardial remodelling such as fibrosis is a major contributor to heart failure with preserved ejection fraction. We sought to determine the relationship between substance P (SP), a sensory neuropeptide, and this adverse remodelling. Using the angiotensin II mouse model of pressure overload we determined that Tac1 -/- mice that are genetically deficient in SP were protected from developing cardiac fibrosis (WT + Ang II = 1.452±0.1523% (n=9) vs Tac1 -/- + Ang II = 0.5678±0.078% (n=10), p&lt;0.0001). We then investigated the association between SP and fibrosis in hypertensive individuals. Plasma from consented individuals showed significantly higher levels of SP in the hypertensive group in comparison to the control group (control = 78.3 ±11.54 ng/mL (n=22), hypertensive = 127±17.5 ng/mL (n=43), p=0.023) (Figure). Interestingly, hypertensive males showed significantly higher levels of plasma SP than the male control group (control = 74.94±14.54 ng/mL (n=17), hypertensive = 143.2±23.96 ng/mL (n=29), p&lt;0.002), while no significant difference existed between these groups in females. Plasma levels of procollagen type 1 C-terminal pro-peptide (PICP), a marker of fibrosis, indicated that hypertensive individuals with SP levels greater than one standard deviation from the mean, had significantly higher levels of PICP (below = 5.539±0.688 ng/mL (n=38), above = 10.52±3.75 ng/mL (n=5), p=0.035). These findings indicate that high levels of plasma SP are associated with increased levels of a marker of fibrosis in hypertensive individuals. The human studies combined with the genetically modified mouse studies indicate an important role for SP in hypertension-induced cardiac fibrosis.
Low temperature nanostructured gelling compositions for water shut-off purposes (2019)

This article presents the results of the development and research of low-temperature nanostructured gelling compositions to water shut-off in EOR. The kinetic and rheological tests of gel-forming compounds of different composition were performed. A physical model of filtration was built and the filtration characteristics of the compositions were studied. The effectiveness of use of water shut-off gelling compositions and their increasing of the oil displacement coefficient was investigated.
Hsa_circ_0004662 Accelerates the Progression of Osteoarthritisvia the microRNA-424-5p/VEGFA Axis (2022)

Hsa_circ_0004662 facilitates OA progression via the miR-424-5p/ VEGFA axis.
Organ biodistribution of Germanium-68 in rat in the presence and absence of [Ga-68]Ga-DOTA-TOC for the extrapolation to the human organ and whole-body radiation dosimetry (2013)

Positron Emission Tomography (PET) and in particular gallium-68 (68Ga) applications are growing exponentially worldwide contributing to the expansion of nuclear medicine and personalized management of patients. The significance of 68Ga utility is reflected in the implementation of European Pharmacopoeia monographs. However, there is one crucial point in the monographs that might limit the use of the generators and consequently expansion of 68Ga applications and that is the limit of 0.001% of Germanium-68 (68Ge(IV)) radioactivity content in a radiopharmaceutical. We have investigated the organ distribution of 68Ge(IV) in rat and estimated human dosimetry parameters in order to provide experimental evidence for the determination and justification of the 68Ge(IV) limit. Male and female rats were injected in the tail vein with formulated [68Ge]GeCl4 in the absence or presence of [68Ga]Ga-DOTA-TOC. The tissue radioactivity distribution data was extrapolated for the estimation of human organ equivalent doses and total effective dose using Organ Level Internal Dose Assessment Code software (OLINDA/EXM). 68Ge(IV) was evenly distributed among the rat organs and fast renal excretion prevailed. Human organ equivalent dose and total effective dose estimates indicated that the kidneys were the dose-limiting organs (185±54 μSv/MBq for female and 171±38 μSv/MBq for male) and the total effective dose was 15.5±0.1 and 10.7±1.2 μSv/MBq, respectively for female and male. The results of this dosimetry study conclude that the 68Ge(IV) limit currently recommended by monographs could be increased considerably (>100 times) without exposing the patient to harm given the small absorbed doses to normal organs and fast excretion.
Doubling Expression of the Low Density Lipoprotein Receptor by Truncation of the 3′-Untranslated Region Sequence Ameliorates Type III Hyperlipoproteinemia in Mice Expressing the Human ApoE2 Isoform (2001)

The primary receptor mediating clearance of apolipoprotein (apo)E- and apoB100-containing lipoproteins from the circulation is the low density lipoprotein (LDL) receptor. Reduced expression of the LDLR is believed to be a precipitating factor in the pathogenesis of type III hyperlipoproteinemia (HLP) in some humans homozygous for the apoE2 allele (APOE*2). To test the effect of genetic changes in LDL receptor expression on the pathogenesis of type III HLP, we have generated a variant allele at the endogenous mouse Ldlr locus that expresses the human LDL receptor transcript. Transcription of the human LDLR minigene is regulated by the endogenous mouse promoter sequence, but a truncation of 3'-untranslated region results in increased mRNA stability. Consequently, in liver of heterozygotes, steady state levels of mouse and human LDLR transcripts are 50 and 180% the levels of total transcript in wild type mice, respectively. Overall, the 2.3-fold normal level of LDLR message in heterozygotes completely ameliorates type III HLP caused by the homozygosity for the human APOE*2 allele, normalizing their plasma lipoprotein profile. We conclude that a modest increase in expression of the LDLR through message stabilization is sufficient to prevent precipitation of type III HLP in mice.
Interactions between a single immunoglobulin-binding domain of protein L from Peptostreptococcus magnus and a human κ light chain (1999)

The placement of a tryptophan residue into a single Ig-bindingdomain of protein L from Peptostreptococcus magnus has been used to examine the binding interactions between the binding domain and light chains (-chains). The fluorescence intensity of the mutant domain increases on the formation of a complex with -chains. This has been used to determine the K d of the complex under a range of conditions by using both pre-equilibrium and equilibrium methods. The K d values determined for the complex with -chains at a number of different pH values are very close to those obtained with the wild-type domain, indicating that the mutation has not substantially affected its binding properties. Examination of the reaction between the mutant domain and -chains by stopped-flow fluorescence shows that complex formation takes place by two discrete, sequential processes. A fast bimolecular reaction, with a rate constant of
Effect of Decontamination Agents on the Microbial Population, Sensorial Quality, and Nutrient Content of Grated Carrots (Daucus carota L.) (2008)

Several decontamination agents including water, sodium hypochlorite, peroxyacetic acid, neutral electrolyzed oxidizing water, and chlorine dioxide gas were tested for their effectiveness to reduce the natural microflora on grated carrots. Microbial reductions of the total aerobic count obtained after the different treatments varied between 0.11 and 3.29 log colony-forming units (cfu)/g. Whether or not a decontamination step induced significant changes in the sensory attributes of grated carrots is highly dependent on the type and concentration of disinfectant. To maintain the nutritional value, the influence of the decontamination agents on carotenoid content, alpha-tocopherol content, total phenols, and antioxidant capacity was studied. Besides the part of the nutrients that was leached away from the cutting areas by water, the nutrient losses caused by adding sanitizers were rather limited. Compared with the untreated carrots alpha-tocopherol content was, however, significantly reduced when 250 ppm of peroxyacetic acid (-80%) or 200 ppm of sodium hypochlorite (-59%) was used. Additional losses in carotenoid content were caused by contact with chlorine dioxide gas (-9%). On the condition of an optimized decontamination process toward time and concentration, the microbial quality of fresh-cut carrots could be improved without negatively influencing their sensory quality and nutrient content.
Encoderless control of synchronous machines with permanent magnets - impact of magnetic design (2010)

High resolution optical encoders are used in industrial servo drives with position and/or speed control for providing the respective feedback signals. In applications with lower accuracy requirements resolvers are used as feedback sensors with respect to lower cost. As a resolver is nothing else than an electrical AC machine of special design, there is the basic idea to operate the servo motor itself like a resolver - in parallel to its original drive operation, of course. High frequency resolver signals are injected to the servo motor without disturbing its original purpose (i. e. the production of torque). The reaction of the servo motor on the high frequency signals can be detected by the current sensors, which are available with respect to the current control loop anyway. A lot of schemes and concepts for encoderless AC drive control providing good operation during standstill are already published. Acceptance by industry, however, is not very extended. The main reasons for hesitations in industry are (1) enhanced processing performance being necessary for the controller or signal processor (2) additional sensors or hardware (3) parameters to be adjusted with respect to encoderless control. A high frequency component is superposed to the current control output signal resulting in a high frequency current response, which can be used for detecting the orientation of the rotor. The position dependent high frequency currents can be measured with the standard current sensors available in industrial drives anyway. There is no need for any additional hardware being not available in standard industrial drives. The estimated rotor position is adjusted by a tracking controller, which works without impact of any machine or drive parameter. Therefore it is possible to detect even small anisotropies as typical for synchronous machines with surface mounted permanent magnets. The software effort is comparable to the software for a rotor model of a standard field oriented control for induction machines. Standard microcontrollers used in servo drives with field oriented control are sufficient to perform the sensorless control scheme. The experimental results presented in this contribution show the encoderless control scheme having no limitations with respect to a minimal speed; the drive is able to provide full torque in encoderless operation even at standstill. The control behaviour of position and speed control is equal to a servo drive with resolver feedback. Recent developments show that synchronous machines with conservative magnetic design show better performance in encoderless control than "modern" motor designs. This contribution shows some interesting results obtained from synchronous machines with permanent magnet excitation as well as from synchronous reluctance machines. Future developments and possibilities will be discussed.
The Roscoe distributed operating system (1979)

Roscoe is an operating system implemented at the University of Wisconsin that allows a network of microcomputers to cooperate to provide a general-purpose computing facility. After presenting an overview of the structure of Roscoe, this paper reports on experience with Roscoe and presents several problems currently being investigated by the Roscoe project.
Molecular and Functional Imaging for Detection of Lymph Node Metastases in Prostate Cancer (2013)

Knowledge on lymph node metastases is crucial for the prognosis and treatment of prostate cancer patients. Conventional anatomic imaging often fails to differentiate benign from metastatic lymph nodes. Pelvic lymph node dissection is an invasive technique and underestimates the extent of lymph node metastases. Therefore, there is a need for more accurate non-invasive diagnostic techniques. Molecular and functional imaging has been subject of research for the last decades, in this respect. Therefore, in this article the value of imaging techniques to detect lymph node metastases is reviewed. These techniques include scintigraphy, sentinel node imaging, positron emission tomography/computed tomography (PET/CT), diffusion weighted magnetic resonance imaging (DWI MRI) and magnetic resonance lymphography (MRL). Knowledge on pathway and size of lymph node metastases has increased with molecular and functional imaging. Furthermore, improved detection and localization of lymph node metastases will enable (focal) treatment of the positive nodes only.
Mineralocorticoid receptors/epithelial Na+ channels in the choroid plexus are involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats (2012)

Increase in cerebrospinal fluid (CSF) Na(+) concentration ([Na(+)]) precedes hypertension and is a key step in the development of salt-induced hypertension. In the choroid plexus (CP), epithelial Na(+) channels (ENaCs) have an important role in Na(+) transport from the blood into the CSF. However, it remains unknown whether the mineralocorticoid receptors (MR)/ENaCs pathway in the CP of stroke-prone spontaneously hypertensive rats (SHRSP) is involved in neural mechanisms of hypertension. Therefore, we examined the role of the MR/ENaCs pathway in the CP in the development of hypertension in SHRSP associated with an increase in CSF [Na(+)]. As a marker of MR activation, serum/glucocorticoid-inducible kinase 1 (Sgk1) expression levels in the CP were measured and found to be greater in SHRSP than in Wistar-Kyoto (WKY) rats. CSF [Na(+)] levels were also higher in SHRSP than in WKY rats. In SHRSP, high-salt intake (8%) increased blood pressure and urinary norepinephrine excretion compared with those in animals fed a regular salt diet (0.5%) for 2 weeks. Furthermore, the expression levels of MR, Sgk1 and ENaCs in the CP and the increase in CSF [Na(+)] were greater in SHRSP fed a high-salt diet than in those fed a regular salt diet. These alterations were attenuated by intracerebroventricular infusion of eplerenone (10 μg kg(-1) per day), except for α-ENaC and β-ENaC. We conclude that activation of the MR/ENaCs pathway in the CP contributes to hypertension via an increase in CSF [Na(+)], thereby exaggerating salt-induced hypertension with sympathetic hyperactivation in SHRSP.
Metabolic Inhibition Alters Subcellular Calcium Release Patterns in Rat Ventricular Myocytes (2005)

Metabolic inhibition (MI) contributes to contractile failure during cardiac ischemia and systolic heart failure, in part due to decreased excitation-contraction (E-C) coupling gain. To investigate the underlying mechanism, we studied subcellular Ca2+ release patterns in whole cell patch clamped rat ventricular myocytes using two-dimensional high-speed laser scanning confocal microscopy. In cells loaded with the Ca2+ buffer EGTA (5 mmol/L) and the fluorescent Ca2+-indicator fluo-3 (1 mmol/L), depolarization from -40 to 0 mV elicited a striped pattern of Ca2+ release. This pattern represents the simultaneous activation of multiple Ca2+ release sites along transverse-tubules. During inhibition of both oxidative and glycolytic metabolism using carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP, 50 nmol/L) and 2-deoxyglucose (2-DG, 10 mmol/L), there was a decrease in inward Ca2+ current (ICa), the spatially averaged Ca2+ transient, and E-C coupling gain, but no reduction in sarcoplasmic reticulum Ca2+ content. The striped pattern of subcellular Ca2+ release became fractured, or disappeared altogether, corresponding to a marked decrease in the area of the cell exhibiting organized Ca2+ release. There was no significant change in the intensity or kinetics of local Ca2+ release. The mechanism is not fully explained by dephosphorylation of L-type Ca2+ channels, because a similar degree of ICa"rundown" in control cells did NOT result in fracturing of the Ca2+ release pattern. We conclude that metabolic inhibition interferes with E-C coupling by (1) reducing trigger Ca2+, and (2) directly inhibiting sarcoplasmic reticulum Ca2+ release site open probability.
Ground-space bilateral teleoperation of ETS-VII robot arm by direct bilateral coupling under 7-s time delay condition (2007)

A bilateral teleoperation experiment with Engineering Test Satellite 7 (ETS-VII) was conducted on November 22, 1999.Round-trip time for communication between the National Space Development Agency of Japan ground station and the ETS-VII was approximately seven seconds.We constructed a bilateral teleoperator that is stable, even under such a long time delay.Several experiments, such as slope-tracing task and peg-in-hole task, were carried out.Task performance was compared between the bilateral mode and the unilateral mode with force telemetry data visually displayed on a screen.All tasks were possible by bilateral control without any visual information.Experimental results showed that kinesthetic force feedback to the operator is helpful even under such a long time delay, and improves the performance of the task.
Evaluation of a smoke evacuator used for laser surgery (1989)

A preliminary study was conducted to determine the effectiveness of a smoke evacuation system used in laser surgery. A 30 W medical CO2 continuous wave (CW) laser was used to make cuts in a pork chop to simulate smoke production during laser surgery. A commercially available smoke evacuation system was used to control the smoke from the simulated surgery. The smoke concentration was measured at 6 in and at 3 and 4 ft from site of laser interaction. The nozzle of the smoke evacuator was located at distances of 2, 6, and 12 in from the surgical site to measure the relative effectiveness of the control. Complete control of smoke was achieved when the nozzle was located at 2 in, but significant amounts of smoke escaped when the nozzle was located at 6 and 12 in. Suggestions for the use of the smoke evacuation system and areas for further study are given.
Component effects on the vanadium oxide thin films phase transition character phenomenon observed (2008)

We present what is, to the best of our knowledge, how the components affect the phase transition character of the vanadium oxide thin films. The vanadium oxide thin films are prepared on zinc selenide by a DC magnet sputtering method for the first time; the components are achieved by the x-ray photoelectron spectroscopy (XPS). The films are annealed to tune their components. A spectral transmittance study has been made from 2.5 to 25.0 μm. We can see that, except for doping, different components can change the phase transition characters of the films. The components can affect the phase transition temperature, hysteresis cycle, and the transmittance.
Privacy Preserving in Blockchain Based on Partial Homomorphic Encryption System for Ai Applications (2018)

The synergy between artificial intelligence and blockchain is increasing in the computing environment. To realize this blockchain technology making its way into applications such as healthcare, financial services, Internet of Things and much more., that use artificial intelligence making it more defendable to attacks. The current blockchain technology uses different encryption algorithms such as SHA256, MD5 etc. The blockchain attacks such as collision attack, primage attack and attacks on wallet motivated us to experiment on partial homomorphic encryption to enhance the strength of blockchain technology. This article considers i) Goldwasser- Micali and ii) Paillier encryption schemes for the comparative evaluation study with a focus on data privacy techniques. We believed and proved that the above two encryption schemes that were considered have less processing time and provide more strength to the possible attacks. While we present our preliminary results in this study, we discuss the pros and cons of the Goldwasser-Micali, Paillier and non-homomorphic encryption schemes that are expected to add value to blockchain technology to be used in Artificial Intelligence (AI) applications.
Rab6 and the secretory pathway affect oocyte polarity inDrosophila (2007)

The Drosophila oocyte is a highly polarized cell. Secretion occurs towards restricted neighboring cells and asymmetric transport controls the localization of several mRNAs to distinct cortical compartments. Here, we describe a role for the Drosophila ortholog of the Rab6 GTPase, Drab6, in establishing cell polarity during oogenesis. We found that Drab6 localizes to Golgi and Golgi-derived membranes and interacts with BicD. We also provide evidence that Drab6 and BicD function together to ensure the correct delivery of secretory pathway components, such as the TGFalpha homolog Gurken, to the plasma membrane. Moreover, in the absence of Drab6, osk mRNA localization and the organization of microtubule plus-ends at the posterior of the oocyte were both severely affected. Our results point to a possible connection between Rab protein-mediated secretion, organization of the cytoskeleton and mRNA transport.
A Digital Current Control of Quasi-Z-Source Inverter With Battery (2012)

This paper presents a fixed frequency operating sliding mode (SM) current control method with fast response and improved stability. Different from the conventional SM control with variable switching frequency, the fixed-frequency SM controller is proposed to control the modulation index and shoot-through duty ratio of the voltage-fed quasi-Z-source inverter (qZSI), which will not increase the passive components and filter design difficulty. A large-signal dynamic model of the system has been established, which can be used for the system stability control in a wide operating range. By using linear approximation, the system small-signal model is also obtained to analyze the control system stability and transient response. Compared with the conventional current mode controller, the proposed SM controller can achieve faster response, lower current ripple and better stability for qZSI when the supply and load variation is large. Experimental results are presented to demonstrate the validity of the theoretical design and the effectiveness of the proposed controller.
A Cluster of Cutaneous Leishmaniasis Associated with Human Smuggling (2011)

Cutaneous leishmaniasis (CL) is rarely seen in the United States, and the social and geographic context of the infection can be a key to its diagnosis and management. Four Somali and one Ethiopian, in U.S. Border Patrol custody, came to the United States by the same human trafficking route: Djibouti to Dubai to Moscow to Havana to Quito; and then by ground by Columbia/Panama to the United States-Mexico border where they were detained. Although traveling at different times, all five patients simultaneously presented to our institution with chronic ulcerative skin lesions at different sites and stages of evolution. Culture of biopsy specimens grew Leishmania panamensis. Soon thereafter, three individuals from East Africa traveling the identical route presented with L. panamensis CL to physicians in Tacoma, WA. We document here the association of a human trafficking route and new world CL. Clinicians and public health officials should be aware of this emerging infectious disease risk.