gebhart/patrepeval huggingface dataset:
Handoff from recombinase to replisome: Insights from transposition (2001)

Bacteriophage Mu replicates as a transposable element, exploiting host enzymes to promote initiation of DNA synthesis. The phage-encoded transposase MuA, assembled into an oligomeric transpososome, promotes transfer of Mu ends to target DNA, creating a fork at each end, and then remains tightly bound to both forks. In the transition to DNA synthesis, the molecular chaperone ClpX acts first to weaken the transpososome's interaction with DNA, apparently activating its function as a molecular matchmaker. This activated transpososome promotes formation of a new nucleoprotein complex (prereplisome) by yet unidentified host factors [Mu replication factors (MRF alpha 2)], which displace the transpososome in an ATP-dependent reaction. Primosome assembly proteins PriA, PriB, DnaT, and the DnaB--DnaC complex then promote the binding of the replicative helicase DnaB on the lagging strand template of the Mu fork. PriA helicase plays an important role in opening the DNA duplex for DnaB binding, which leads to assembly of DNA polymerase III holoenzyme to form the replisome. The MRF alpha 2 transition factors, assembled into a prereplisome, not only protect the fork from action by nonspecific host enzymes but also appear to aid in replisome assembly by helping to activate PriA's helicase activity. They consist of at least two separable components, one heat stable and the other heat labile. Although the MRF alpha 2 components are apparently not encoded by currently known homologous recombination genes such as recA, recF, recO, and recR, they may fulfill an important function in assembling replisomes on arrested replication forks and products of homologous strand exchange.
Robustesse en performance des systemes lineaires incertains : placement de poles et cout garanti (1997)

Cette these s'inscrit dans la mouvance des travaux relatifs a la synthese de lois de commandes robustes permettant de conferer au systeme commande un certain niveau de performance. On considere essentiellement des systemes lineaires decrits dans l'espace d'etat et soumis a des incertitudes parametriques. La robustesse en stabilite est envisagee a ravers le concept de stabilisabilite quadratique. La performance quant a elle est abordee dans deux directions. La premiere est une generalisation au cas des systemes incertains du probleme de rejet de perturbation h#2. Il s'agit de minimiser une borne superieure de la norme h#2 de la matrice de transfert entre une perturbation exogene et une sortie controlee. La loi de commande obtenue est qualifiee, dans ce cas, de commande a cout garanti. La deuxieme est fondee sur le placement de poles. En presence de l'incertitude, et contrairement au cas des systemes parfaitement connu, une localisation des poles ne peut se faire que dans une region du plan complexe et non en des points bien definis. Pour des raisons d'efficacite, mais aussi liees a des aspects purement pratiques, la region de placement choisie est un disque. Sont alors developpees des techniques permettant de localiser les poles dans un disque, techniques valables aussi bien pour les systemes a temps continu qu'a temps discret. En outre, lorsque le systeme presente en plus de l'incertitude parametrique, une incertitude liee aux dynamiques rapides negligees, le probleme de robustesse en performance est aborde a travers l'utilisation de la modelisation sous forme de systemes singulierement perturbes incertains. L'efficacite des concepts et des outils numeriques presentes dans cette these est mise en evidence sur deux applications : la commande d'un bras manipulateur souple et la synthese d'une loi de pilotage.
Predicted structures of the cGMP binding domains of the cGMP-dependent protein kinase: a key alanine/threonine difference in evolutionary divergence of cAMP and cGMP binding sites (1989)

Mammalian cGMP- and cAMP-dependent protein kinase show considerable similarity in amino acid sequence, although they specifically bind different cyclic nucleotides. Results of cGMP analogue binding experiments, combined with modeling of the cGMP binding sites by analogy to the structure of the homologous catabolite gene activator protein, suggest that a threonine residue forms a hydrogen bond with the 2-NH2 of cGMP. This threonine is invariant in all cGMP binding domains, but the corresponding residue in 23 out of 24 cAMP binding sites of protein kinases is alanine, which cannot form the same hydrogen bond. This alanine/threonine difference has the potential for discriminating between cAMP and cGMP and may be important in the evolutionary divergence of cyclic nucleotide binding sites.
Spatial Spread of Interocular Suppression is Guided by Stimulus Configuration (2009)

When the two eyes view dissimilar monocular stimuli, the resulting interocular suppression can spread beyond the region of explicit stimulus conflict: portions of one rival target will disappear even though there is no competing stimulation at the corresponding location in the other eye's view. In a series of experiments we examined whether this spread of suppression is spatially isotropic or governed by the configuration of the stimulus a portion of which is subject to suppression. Observers reported the incidence of stimulus disappearance at different locations along or nearby the contours of a large figure, part of which was suppressed by presentation of a continuous flash-suppression stimulus to a restricted region of the other eye. For all observers, suppression spread over several degrees along the contours of the figure, but tended not to spread to locations nearby but disconnected from the figure. Suppression spread effectively over a smoothly curved contour, and it spread around a sharp corner defined by two abutting contours, albeit less effectively. Suppression tended not to spread to features within the interior of a figure (a face), even if those features formed an integral part of the figure. A gap within a spatially extended stimulus arrested the spread of suppression, unless that gap appeared to arise from occlusion. Spread of suppression was unrelated to sensory eye dominance and was found with a more conventional binocular rivalry configuration, too. These findings implicate the involvement of neural circuitry in which inhibition propagates along paths of excitation beyond spatial regions of explicit interocular conflict.
Dynamics of reverse annealing for the fully connected p-spin model (2019)

Reverse annealing, a variant of quantum annealing, is investigated by probing quantum transitions in a $p$-spin model and comparing it with the predictions offered by equilibrium statistical mechanics. It is shown that reverse annealing can provide an exponential speedup over conventional quantum annealing for this particular problem.
Evaluation of empirical and fundamental test methods for permanent deformations of bituminous bound materials (2006)

The new European Standards within the EN 13108 series specify several test methods for evaluating permanent deformation behavior of bituminous bound mixtures. In these standards two ways of addressing requirements for asphalt concrete are described: an empirical approach that specifies asphalt concrete in terms of compositional recipes and requirements for constituent materials with additional requirements based on performance related tests (also called empirical tests), such as wheel tracking tests (WTT). The other approach is the fundamental approach that specifies asphalt concrete in terms of performance-based requirements and test methods (also called fundamental tests), such as triaxial cyclic compression tests (TCCT) linked to limited prescription of composition and constituent materials. As part of an European research project, called SAMARIS, several laboratory tests (empirical wheel tracking tests WTT and fundamental cyclic compression tests CCT) and field experiments (full scale tests with alternate loading test devices ALT) on the same hot mix asphalt (HMA) materials have been performed in different laboratories. For the first time, tests results obtained from all these different test methods have been compared to achieve information about their comparability, in particular the comparability of the different wheel tracking test WTT procedures (specified in EN 12697-22) for possible future rationalization of the European Standards EN13108 series. In this paper some test results of these permanent deformation tests (WTT, ALT and CCT) are presented and compared according to their comparability (A). For the covering abstract of the conference see ITRD E212343.
Distribution of CYP2C9 and VKORC1 Risk Alleles for Warfarin Sensitivity and Resistance in the Israeli Population (2010)

Individualized genotype based warfarin therapy is highly relevant in the Israeli population due to the high incidence of genetic variations associated with warfarin sensitivity in all 3 non-mixing subpopulations tested.
Experimental investigation of chemical-looping combustion and chemical-looping gasification of biomass-based fuels using steel converter slag as oxygen carrier (2018)

Chemical-looping combustion (CLC) is a combustion process with inherent separation of CO2, which is achieved by oxidizing the fuel with a solid oxygen carrier rather than with air. As fuel and combustion air are never mixed, no gas separation is necessary and, consequently, there is no direct energy penalty for the separation of gases. The most common form of design of chemical-looping combustion systems uses circulating fluidized beds, which is an established and widely spread technology.Experiments were conducted in two different laboratory-scale CLC reactors with continuous fuel feeding and nominal fuel inputs of 300 Wth and 10 kWth, respectively. As oxygen carrier material, ground steel converter slag from the Linz–Donawitz process was used. This material is the second largest flow in an integrated steel mill, and it is available in huge quantities, for which there is currently limited demand. Steel converter slag consists mainly of oxides of Ca, Mg, Fe, Si and Mn. In the 300 W unit chemical-looping combustion experiments were conducted with model fuels syngas (50 vol% H2 in CO) and methane at varied reactor temperature, fuel input and oxygen-carrier circulation. Further, the ability of the oxygen-carrier material to release oxygen to the gas phase was investigated. In the 10 kW unit, the fuels used for combustion tests were steam-exploded pellets and wood char. The purpose of these experiments was to study more realistic biomass fuels and to assess the lifetime of the slag when employed as oxygen carrier. In addition, chemical-looping gasification was investigated in the 10 kW unit using both, steam-exploded pellets and regular wood pellets as fuels.In the 300 W unit, up to 99.9 % of syngas conversion was achieved at 280 kg/MWth and 900 °C, while the highest conversion achieved with methane was 60 % at 280 kg/MWth and 950 °C. The material’s ability to release oxygen to the gas phase, i.e., CLOU property, was developed during the initial hours with fuel operation, and the activated material released 1-2 vol% of O2 into a flow of argon between 850 °C and 950 °C. The material’s initial low density decreased somewhat during CLC operation.In the 10 kW, CO2 yields of 75-82 % were achieved with all three fuels tested in CLC conditions, while carbon leakage was very low in most cases, i.e., below 1 %. With wood char as fuel, at a fuel input of 1.8 kWth, a CO2 yield of 92 % could be achieved. The carbon fraction of C2-species was usually below 2.5 % and no C3-species were detected. During chemical-looping gasification investigation a raw gas was produced that contained mostly H2. The oxygen carrier lifetime was estimated to be about 110-170 h. However, due to its high availability and potentially low cost, this type of slag could be suitable for large-scale operation.
Size-isolation of ultrasound-mediated phase change perfluorocarbon droplets using differential centrifugation (2016)

Perfluorocarbon droplets that are capable of an ultrasound-mediated phase transition have applications in diagnostic and therapeutic ultrasound. Techniques to modify the droplet size distribution are of interest because of the size-dependent acoustic response of the droplets. Differential centrifugation has been used to isolate specific sizes of microbubbles. In this work, differential centrifugation was employed to isolate droplets with diameters between 1 and 3 μm and 2 and 5 μm from an initially polydisperse distribution. Further, an empirical model was developed for predicting the droplet size distribution following differential centrifugation and to facilitate the selection of centrifugation parameters for obtaining desired size distributions.
STUDY OF CARBONATION DURABILITY OF SEVERAL ETTRINGITE-ENRICHED PASTES (2019)

Recent reported materials of high energy density for thermochemical heat storage are mostly inorganic rare elements salts, such as SrBr2 and LaCl3.However, their wide use may be hindered due to the high material cost.An affordable cement-based compound, named ettringite, of which energy density (~500 kWh/m 3 ) is comparable, and even higher, than rare elements salts and therefore attracts people's sight.As an alkaline phase in hydrated cement pastes, ettringite could be carbonated by CO2 in the air.The change of this mineral structure upon carbonation could reduce its capacity to store energy.This phenomenon is known to be unstoppable until there is a complete depletion of reactants.Consequently, it is necessary to investigate the carbonation rate of ettringite-based materials for energy storage.In the present work, a large range of characterization methods -such as optical microscopy analysis, mercury intrusion porosimetry (MIP), X-ray fluorescence (XRF), X-ray diffraction (XRD), Thermogravimetric analysis (TGA) -have been carried out to analyse phase structure and phase assemblage.Three series of cement pastes containing different contents of ettringite were firstly prepared.Then, crushed samples of a size of 1-2mm were exposed to an accelerated carbonation environment (composed of 1% CO2 by volume, and 90% relative humidity (RH) at 20°C and ambient pressure) for different durations.The results have highlighted that the carbonation of ettringite-based granules under set conditions went very fast.The XRD patterns confirmed that the calcium carbonates were vaterite and aragonite accompanied with gypsum.Moreover, a bigger content of ettringite seemed to yield a higher carbonation resistance and a less foamy structure.
Microstructure Control of Ni-Zn Ferrite for Thin Films of Magnetic Recording Heads (1992)

In this experiment, the microstructural changes during sintering of Ni-Zn ferrites used as the substrate for magnetic recording heads of thin films have been studied by SEM, XRD and XPS. The results obtained are sammarized as follows.(1) No precipitates were recognized on the specimen furnace-cooled from 1423 K during sintering in air. ZnO precipitates, however, were observed at the grain boundary, especially at the triple point of the specimen furnace-cooled from 1453 K. These precipitates have been elongated along grain boundaries of the specimen furnace-cooled from 1453 K after holding at this temperature for 10.8 ks.(2) While the above mentioned ZnO precipitates were not observed on the specimen sintered in O2 atmosphere, the grain coarsening was observed and the residual pores were also recognized inside the grain.(3) The existence of Ni3+ ion was detected by XPS on the specimen prepared by HIP process at 1373 K for 18 ks under 120 MPa after sintering in air at 1453 K for 10.8 ks, where the ratio of Ni3+/(Ni2++Ni3+) was confirmed to be 3%.
Nonlinear‐Dispersive Similaritons of Passive Fibers: Applications in Ultrafast Optics (2017)

Similariton pulses with their distinctive property of self-similar propagation, recently have attracted the attention of researchers due to fundamental interest and prospective applications in ultrafast optics and photonics, particularly for high-power pulse amplification, optical telecommunications, ultrafast all-optical signal processing, etc. From a practical point of view, both the parabolic similariton of active fiber and the nonlinear-dispersive (NL-D) similariton of passive fiber are of interest for applications to ultrafast optics and photonics, namely, for femtosecond signal generation, characterization, delivery, and processing. This chapter subjects the generation and applications of broadband NL-D similariton to nonlinear ultrafast photonics. It reviews the studies of the nature and peculiarities of the NL-D similaritons generated in passive fiber and specificity of broadband similaritons with applications to ultrafast photonics. The chapter presents similariton-induced time lensing, aberrationfree spectral focusing, similariton-based spatiotemporal imaging, and self-referencing spectral interferometry methods. Finally, it discusses the prospects of similaritons for material characterization, and for simple femtosecond signal characterization.
Evaluation Of Leg-to-leg Bioelectrical Impedance Analysis In Assessing Body Composition Of High-school Wrestlers (2005)

PUPOSE To evaluate the accuracy of leg-to-leg bioelectrical impedance analysis (BIA) in assessing FFM using the TANITA: TBF-300WA in comparison to hydrostatic weighing (HW) and skinfolds (SK) in high-school (HS) wrestlers in hydrated state. METHODS Body composition was determined by BIA, HW, and 3-site (SK) in 129 HS wrestlers (Mean ± SD, age: 15.5 ± 1.3, height 1.70 ± 0.08 m, body mass 65.6 ± 13.1 kg). For all methods, body density (Db) was converted to percent body fat (%BF) using the Brozek equation. Hydration state was quantified by evaluating urine specific gravity. RESULTS There were no significant differences for estimated fat-free mass (FFM) between BIA (56.9 ±8.4 kg) and HW (56.2 ± 9.9 kg) or between SK (56.1 ± 8.9 kg) and HW. The standard errors of estimate for FFM with HW as the reference method were 3.64 kg for BIA and 1.97 kg for SK. Significant correlations were found for FFM between HW and BIA (r = 0.93, P < 0.001), and between HW and SK BIA (r = 0.98, P < 0.001). The FFM difference between BIA and HW was significantly correlated with the FFM average of the two methods (r = −0.39, P < 0.001). The FFM difference between SK and HW was also significantly correlated with the FFM average (r = −0.44, P < 0.001). CONCLUSIONS This study demonstrates that the TANITA: TBF-300WA BIA analyzer estimates FFM within an acceptable range when compared to HW in a high-school wrestlers.
ChemInform Abstract: COORDINATION CHEMISTRY OF FUNCTIONAL PHOSPHORUS YLIDES. IV. CRYSTAL STRUCTURE E OF 2‐METHYL‐2‐(TRIPHENYLPHOSPHONIO)DITHIOPROPIONATE AND 3,5‐DIISOPROPYLIDENE‐1,2,4‐TRITHIOLANE. COURSE OF THE BETAINE‐TRITHIOLANE REARRANGEMENT (1983)

Abstract Das Additionsprodukt des P‐Ylids (I) und CS 2 , das Betain (II), liefert als thermisches Folgeprodukt das Dialkylidentrithiolan (IV), das wahrscheinlich durch [3 + 2]‐Cycloaddition des Thioketens (III) und des Betains (II) unter Triphenylphosphin‐Eliminierung entsteht.
Anti-NMDA receptor encephalitis: Pathogenic mechanisms and treatment algorithm (2012)

Since the discovery of anti-NMDA receptor encephalitis in 2007, it has become the most frequent and best studied CNS disorder caused by antibodies to cell surface or synaptic proteins. The disorder preferentially affects young women, although men and children can also be affected. The association with an underlying tumor, usually a teratoma, varies according to the patient’s age, gender, and ethnicity. The associated neuropsychiatric syndrome develops in stages and is highly predictable, with limited variation among individuals and age. The antibodies are directed against the N-terminal domain of the NR1 subunit of the NMDAR, and their levels, relative to total IgG, are always higher in CSF than serum. Multiple studies have confirmed an intrathecal synthesis of antibodies probably by the meningealand brain-infiltrating plasma cells. In vitro and in vivo studies show structural and functional effects of the antibodies resulting in a specific reduction of the levels of synaptic NMDAR by a mechanism of antibody capping, cross-linking and internalization of the receptors. These effects correlate with the antibody titers and are reversible upon removing the antibodies. In addition, the antibodies abrogate NMDAR-mediated currents potentially altering the mechanisms of synaptic plasticity. Cortical injection of antibodies results in an increase of glutamate release, enhancing the excitability of the motor cortex. Autopsy studies have confirmed a decrease of NMDAR levels in the brain regions with higher concentration of antibodies. Overall, these antibody effects coupled with the characteristic clinical syndrome resemble those predicted from models of genetic or pharmacological decrease of NMDAR function. All of these findings must be considered for the development of treatment strategies that should be directed not only to remove antibodies from serum but also to abrogate the inflammatory infiltrates and synthesis of antibodies within the CNS.
Determination of spatial and temporal characteristics as an aid to neural network cloud classification (1997)

Previous studies of cloud classification from meteorological satellite imagery have shown that artificial neural networks (ANNs) perform as well as, or better than, statistical pattern recognition when multispectral features, supplemented with selected textural features, are used. These features, however, represent only a subset of the full range of features available in this imagery. Spatial characteristics based on the shape of clouds, and temporal characteristics, derived from image sequences, can be more direct pointers to cloud type. In this paper the methods for the determination of such parameters are described, some results are presented, and the effectiveness of the methods are discussed.
Development of laser turning using femtosecond laser ablation (2002)

Ablation using femtosecond-lasers has taken much attention for micromachining with the advantages of efficient ultra-thin layer peeling without undesirable thermal effects for both opaque and transparent materials. In this work, we have proposed the femtosecond-laser turning based on the fact that femtosecond-laser ablation is a promising technique for excellent surface finishing techniques. The effect of the machining conditions such as focusing condition, energy of laser pulse and plural scanning, on the thickness of peeling layer for various kinds of materials (PMMA, silica glass, silicon, copper and aluminum) have been investigated. As a result, the important information for the laser turning as a practical application of the femtosecond lasers were obtained.
SLOW AND FAST STRUCTURE OF SECONDARY - PARTICLE BEAMS OF THE BEVATRON (1956)

This report summarizes the results of a coordinated investigation of the structure of the secondary-particle beams of the Bevatron.The debunching and spiral in time of the primary beam have been determined for typical experimental conditions.Two of the methods of secondary-beam production, which are discussed here, have been used extensively in cloud-chamber and counter-type experiments.Three new methods of secondary-beam production have been studied in some detail.The radiofrequency structure, s'ynchrotron oscillation structure, magnet-ripple structure, and duration of the secondarybeam pulse are reported for each of these methods.
Delegation of Work Within a Patient-Centered Medical Home (2022)

Findings indicated a need for clear guidance on roles and responsibilities within the team. Patient-centered medical home team members need information about the scope of practice of each professional group to allow providers to function at the top of their scope of practice and ensure effective delegation.