gebhart/patrepeval huggingface dataset:
Enzymes in Farm Animal Nutrition (2022)

<title>Abstract</title> This third edition explores considerable advances such as the use of enzymes in fish and shrimp diets, new understanding of how phytases function in the animal, NSPase research and enzymes' extended use in ruminant markets. This book also provides comprehensive coverage of all topics relating to the production, use, cooperativity and analysis of feed enzymes. It is fully updated throughout, revealing significant developments such as new methods to deliver enzymes (formulations, encapsulations, and liquid spray systems) and advances in enzyme analysis. It also includes brand new chapters on combinations of enzymes, antibiotic-free diets and how to measure response in feed-enzyme trials. Covering biochemistry, enzymology and characteristics relevant to animal feed use, this book forms a valuable resource for academics and students of animal nutrition and production, as well as professionals in the animal feed industry.
Surface micromachined devices for microwave and photonic applications (1998)

As an enabling technology, Micro Electro Mechanical Systems (MEMS) have continuously provided new and improved design/implementation paradigms for a variety of scientific and engineering applications. In this paper, we review recent advances made in MEMS and its derivative MOEM devices for both microwave and photonic applications.
Classifications of Breast Cancer Images by Deep Learning (2020)

Abstract Background Breast cancer is a leading cause of cancer-related death in women. Classifications of pathological images are important for its diagnosis and prognosis. However, the existing computational methods can sometimes hardly meet the accuracy requirement of clinical applications, due to uneven color distribution and subtle difference in features. Methods In this study, a novel classification method DeepBC was proposed for classifying the pathological images of breast cancer, based on the deep convolution neural networks. DeepBC integrated Inception, ResNet, and AlexNet, extracted features from images, and classified images of benign and malignant tissues. Results Additionally, complex tests were performed on the existing benchmark dataset to evaluate the performance of DeepBC. The evaluation results showed that, DeepBC achieved 92% and 96.43% accuracy rates in classifying patients and images, respectively, with the F1-score of 97.38%, which better than the state-of-the-art methods. Conclusions These findings indicated that, the model had favorable robustness and generalization, and was advantageous in the clinical classifications of breast cancer.
Hydrogen gas sample environment for TOSCA (2014)

The idea of using hydrogen as a fuel has gained immense popularity over many years. Hydrogen is abundant, can be produced from renewable resources and is not a greenhouse gas. However development of hydrogen based technology is impossible without understanding of physical and chemical processes that involve hydrogen sometime in extreme conditions such as high pressure or low and high temperatures. Neutron spectroscopy allows measurement of a hydrogen atom motion in variety of samples. Here we describe and discuss a sample environment kit developed for hydrogen gas experiment in a broad range of pressure up to 7 kbar and temperatures from 4 K to 473 K. We also describe para-hydrogen rig which produces para-hydrogen gas required for studying the rotational line of molecular hydrogen.
Plant Scaffolds Support Motor Recovery and Regeneration in Rats after Traumatic Spinal Cord Injury (2020)

ABSTRACT As of yet, no standard of care incorporates biomaterials to treat traumatic spinal cord injury (SCI). However, intense development of biomaterials for treating SCI has focused on fabricating microscale channels to support the regrowth of axons while minimizing scar formation. We previously demonstrated that plant tissues could be decellularized and processed to form sterile, biocompatible and implantable biomaterials that support cell infiltration and vascularization in vivo . Vascularized plant tissues contain continuous microscale channels with geometries relevant for supporting neural regeneration. We hypothesized that decellularized vascular bundles would support neural regeneration and motor recovery in SCI. Sprague Dawley rats received a complete T8-T9 spinal cord transection and were implanted with acellular plant-derived scaffolds and allowed to recover over 28 weeks. Animals that received the scaffolds alone, with no other therapeutic compounds, demonstrated a significant and stable partial improvement in motor function compared to control animals as early as week 4 post-injury. Hind-limb motor function did not deteriorate over the remaining 28 weeks. Histological analysis revealed minimal astrocyte scarring at the spinal cord - scaffold interface, aligned axonal projection through the scaffolds, populations of serotonergic neurons and Schwann cells, laminin and collagen deposition and the presence of blood vessels. Axonal reconnection via the scaffold was also confirmed by Fluro-gold retrograde tracing. Taken together, our work defines a novel route for building upon naturally occurring plant microarchitectures to support the repair of the spinal cord post-injury. Notably, these results were achieved without the use of growth factors, stem/progenitor cells, or any other interventions.
Global Matching with Overlapping Attention for Optical Flow Estimation (2022)

Optical flow estimation is a fundamental task in computer vision. Recent direct-regression methods using deep neural networks achieve remarkable performance improvement. However, they do not explicitly capture long-term motion correspondences and thus cannot handle large motions effectively. In this paper, inspired by the traditional matching-optimization methods where matching is introduced to handle large displacements before energy-based optimizations, we introduce a simple but effective global matching step before the direct regression and develop a learning-based matching-optimization framework, namely GMFlowNet. In GMFlowNet, global matching is efficiently calculated by applying argmax on 4D cost volumes. Additionally, to improve the matching quality, we propose patch-based overlapping attention to extract large context features. Extensive experiments demonstrate that GMFlowNet outperforms RAFT, the most popular optimization-only method, by a large margin and achieves state-of-the-art performance on standard benchmarks. Thanks to the matching and overlapping attention, GMFlowNet obtains major improvements on the predictions for textureless regions and large motions. Our code is made publicly available at https://github.com/xiaofeng94/GMFlowNet
Soy Protein Isolate Solubility and Surface Hydrophobicity as affected by Antioxidants (1995)

ABSTRACT Addition of tert‐butylhydroquinone or a mixture of butylated hydroxyanisole and tert‐butylhydroquinone (200 ppm on a lipid basis) during SPI processing gave increased protein solibility over that of the control (55%. 56% and 34%. respectively). These increased solubilities correspond to 32% and 18% decrease in oxidation of free sulfhydryls and 20% and 12% reduction in protein oxidation, as determined by protein carbonyl content. Increased protein solubilities, due to added antioxidants, were accompanied by higher total protein surface hydrophobicity, as determined by the sodium dodecyl sulfate (SDS) binding method, and soluble protein hydrophobicity, as determined by the fluorescence probe 8‐anilino‐1‐naphthalene sulfonate (ANS).
Superconducting proximity effect in inverted InAs/GaSb quantum well structures with Ta electrodes (2014)

We present our recent electronic transport results in top-gated InAs/GaSb quantum well hybrid structures with superconducting Ta electrodes. We show that the transport across the InAs−Ta junction depends largely on the interfacial transparency, exhibiting distinct zero-bias behavior. For a relatively resistive interface, a broad conductance peak is observed at zero bias. When a transparent InAs−Ta interface is achieved, a zero-bias conductance dip appears with two coherent-peak-like features forming at bias voltages corresponding to the superconducting gap of Ta. The conductance spectra of the transparent InAs−Ta junction at different gate voltages can be fit well using the standard Blonder-Tinkham-Klapwijk theory.
Proteolytically Activated, Recombinant Anti-Müllerian Hormone Inhibits Androgen Secretion, Proliferation, and Differentiation of Spermatogonia in Adult Zebrafish Testis Organ Cultures (2011)

Anti-Müllerian hormone (Amh) is in mammals known as a TGFβ type of glycoprotein processed to yield a bioactive C-terminal homodimer that directs regression of Müllerian ducts in the male fetus and regulates steroidogenesis and early stages of folliculogenesis. Here, we report on the zebrafish Amh homologue. Zebrafish, as all teleost fish, do not have Müllerian ducts. Antibodies raised against the N- and C-terminal part of Amh were used to study the processing of endogenous and recombinant Amh. The N-terminally directed antibody detected a 27-kDa protein, whereas the C-terminally directed one recognized a 32-kDa protein in testes extracts, both apparently not glycosylated. The C-terminal fragment was present as a monomeric protein, because reducing conditions did not change its apparent molecular mass. Recombinant zebrafish Amh was cleaved with plasmin to N- and C-terminal fragments that after deglycosylation were similar in size to endogenous Amh fragments. Mass spectrometry and N-terminal sequencing revealed a 21-residue N-terminal leader sequence and a plasmin cleavage site after Lys or Arg within Lys-Arg-His at position 263-265, which produce theoretical fragments in accordance with the experimental results. Experiments using adult zebrafish testes tissue cultures showed that plasmin-cleaved, but not uncleaved, Amh inhibited gonadotropin-stimulated androgen production. However, androgens did not modulate amh expression that was, on the other hand, down-regulated by Fsh. Moreover, plasmin-cleaved Amh inhibited androgen-stimulated proliferation as well as differentiation of type A spermatogonia. In conclusion, zebrafish Amh is processed to become bioactive and has independent functions in inhibiting both steroidogenesis and spermatogenesis.
Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity (2014)

Our data confirm an inverse correlation between irisin levels and vertebral fragility fractures, but no significant correlation was found with BMD or lean mass. Irisin may play a protective role on bone health independent of BMD but further studies are needed to clarify the relationship between irisin and bone metabolism.
Equivalent circuit modelling of integrated traveling-wave optical modulator in InP foundry platform (2016)

In this paper we present an electro-optical model for traveling-wave modulator devices utilizing measurement-based equivalent circuit model extraction in conjunction with microwave CAD simulation techniques. Model verification is performed with frequencydomain and time-domain characterization of an integrated Mach-Zehnder modulator from an InP Foundry process.
Providing better support for a class of decision support queries (1996)

Relational database systems do not effectively support complex queries containing quantifiers ( quantified queries ) that are increasingly becoming important in decision support applications. Generalized quantifiers provide an effective way of expressing such queries naturally. In this paper, we consider the problem of processing quantified queries within the generalized quantifier framework. We demonstrate that current relational systems are ill-equipped, both at the language and at the query processing level, to deal with such queries. We also provide insights into the intrinsic difficulties associated with processing such queries. We then describe the implementation of a quantified query processor, Q 2 P, that is based on multidimensional and boolean matrix structures. We provide results of performance experiments run on Q 2 P that demonstrate superior performance on quantified queries. Our results indicate that it is feasible to augment relational systems with query subsystems like Q 2 P for significant performance benefits for quantified queries in decision support applications.
Facile Synthesis of Luminescent AgInS2–ZnS Solid Solution Nanorods (2013)

Highly luminescent semiconducting AgInS2–ZnS solid solution nanorods are successfully prepared by a facile one-pot solvothermal method. The resulting solid solution nanorods with length of 32 ± 5 nm are formed by fast growth of the AgInS2-rich solid solution head, followed by slow growth of the ZnS-rich solid solution tail. Photoluminescence studies on the solid solution nanorods reveal strong photoluminescence with peak emission wavelengths tunable from 650 to 700 nm.
Sputtered Manganese Dioxide as Counterelectrodes in Thin Film Capacitors (1972)

Manganese dioxide films were sputtered with resistivities as low as 0.3 ohm‐cm. (TMM) capacitors were fabricated and found to have dissipation factors of 0.008 at 1 kHz and 0.011 at 100 kHz. Leakage currents for the TMM capacitors were 10−9A when measured at 75V (33% of the anodizing voltage). By chemically removing the sputtered from the capacitors and then replacing the counterelectrodes the effect of sputtering on the dielectric could be observed. It was found that d‐c sputtering conditions increased the dielectric dissipation factor by ≤20% while the conditions caused a 50% increase in the dielectric dissipation factor. The sputtered films were found to be and showed a conduction activation energy of 0.10 eV (±0.01) for and indicating that similar material has been deposited under both sputtering conditions.
Export of a Toxoplasma gondii Rhoptry Neck Protein Complex at the Host Cell Membrane to Form the Moving Junction during Invasion (2009)

One of the most conserved features of the invasion process in Apicomplexa parasites is the formation of a moving junction (MJ) between the apex of the parasite and the host cell membrane that moves along the parasite and serves as support to propel it inside the host cell. The MJ was, up to a recent period, completely unknown at the molecular level. Recently, proteins originated from two distinct post-Golgi specialised secretory organelles, the micronemes (for AMA1) and the neck of the rhoptries (for RON2/RON4/RON5 proteins), have been shown to form a complex. AMA1 and RON4 in particular, have been localised to the MJ during invasion. Using biochemical approaches, we have identified RON8 as an additional member of the complex. We also demonstrated that all RON proteins are present at the MJ during invasion. Using metabolic labelling and immunoprecipitation, we showed that RON2 and AMA1 were able to interact in the absence of the other members. We also discovered that all MJ proteins are subjected to proteolytic maturation during trafficking to their respective organelles and that they could associate as non-mature forms in vitro. Finally, whereas AMA1 has previously been shown to be inserted into the parasite membrane upon secretion, we demonstrated, using differential permeabilization and loading of RON-specific antibodies into the host cell, that the RON complex is targeted to the host cell membrane, where RON4/5/8 remain associated with the cytoplasmic face. Globally, these results point toward a model of MJ organization where the parasite would be secreting and inserting interacting components on either side of the MJ, both at the host and at its own plasma membranes.
Measurement and scale‐up of secondary nucleation kinetics for the potash alum‐water system (1979)

Abstract Secondary nucleation kinetics for potash alum in draft‐tube baffled crystallizers have been determined from steady state crystal size distributions measured down to about 5 μm. Differences in nucleation rates were found for crystallizers of similar geometry but different capacity. Models relating the frequency of crystal/propeller collisions to crystallizer geometry and operating parameters were compared. In general, these successfully accounted for the observed differences in nucleation rates.
GH Treatment in Adults with Chronic Liver Disease: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study (2002)

Patients with chronic liver disease (CLD) are catabolic and GH-resistant. The effects of supraphysiological recombinant human GH (rhGH; 0.2 IU·kg−1·d−1) treatment in adults with CLD were assessed in a randomized, double-blind, placebo-controlled cross-over trial (4-wk dietary run-in, 4-wk treatment, and 2-wk wash-out phases). Nine adults with mild- to moderate-severity CLD participated (median age, 49 yr; three males and six females; Child's classification A in six and B in three). Biopsy-proven etiologies were: alcohol (four patients), primary biliary cirrhosis (three patients), non-A, non-B, non-C hepatitis (one patient), and cryptogenic (one patient). Treatment with rhGH increased serum IGF-I (median increase over placebo, +93 μg·liter−1; P = 0.004), IGF-binding protein-3 (+0.9 mg·liter−1: P = 0.004), and acid labile subunit (+10.7 nm; P = 0.004). Total body potassium (+8.0 g; P = 0.023), body weight (+1.6 kg; P = 0.008), and total body water (by bioelectrical impedance; +4.9 kg; P = 0.004) increased. Resting metabolic rate (+313 ml·kg−1·min−1; P = 0.004) and lipid oxidation (+1072.0 kcal·d−1; P = 0.032) increased. Metabolic changes included increased fasting plasma glucose (+1.2 mm; P = 0.008), insulin (+33.8 mU·liter−1; P = 0.004), C-peptide (+0.7 nm; P = 0.004), and free-fatty acids (+0.1 mEq·liter−1; P = 0.04). Clinical side effects included worsening edema and ascites. Hepatocellular function did not change. Therefore, rhGH treatment in CLD: 1) overcame hepatic GH resistance; 2) may have improved whole-body protein catabolism; 3) increased lipolysis and lipid oxidation; 4) increased insulin resistance; and 5) had potent antinatriuretic effects. Long-term safety and efficacy require further assessment.
Who is the ‘smart’ resident in the digital age? The varied profiles of users and non-users in the contemporary city (2019)

This paper is centred on the levels of participation in digital municipal platforms, and its goals are threefold: (1) to assess the normative aspirations and limitations of policy makers and key actors in the municipality with regard to the smart resident idea, with a focus on participation and privacy; (2) to assess and categorise levels of participation in varied social and geographic contexts in the city; and (3) to assess the possible link between participation and privacy practices among users. Empirically, this paper studies the practices of the inhabitants of Tel Aviv-Yafo City, with a focus on the use of digitised services provided by the municipality and the use of the celebrated project ‘Digi-Tel’ – a digital card that offers to the inhabitants of the city services, discounts, targeted information and benefits around the city. The assessment of the inhabitants’ practices is based on a survey that was conducted in four neighbourhoods with different socio-economic, ethnic and geographical characteristics. The survey is supplemented with interviews of prominent figures in the Tel Aviv-Yafo municipality to understand their views on participation and privacy. The paper concludes with a discussion of the varied profiles of the users and non-users of digital platforms in the city, revealing their complex approach to participation in the digital age.
Further characterization of Δ8-sphingolipid desaturases from higher plants (2000)

A previously cloned cDNA from Helianthus annuus codes for a fusion protein composed of an N-terminal cytochrome b(5) and a C-terminal desaturase domain. For a functional identification, this cDNA was expressed in Saccharomyces cerevisiae and the structures of sphingolipid long-chain bases were analysed. The expression of this sunflower enzyme resulted in the formation of new Delta(8)-trans/cis-phytosphingenine from C(18)- and C(20)-phytosphinganine present in wild-type yeast cells. To elucidate the substrate specificity, the recently cloned Delta(8)-sphingolipid desaturases from Arabidopsis thaliana and Brassica napus were expressed in the yeast mutant sur2Delta that lacked the sphinganine C(4)-hydroxylase and was thus unable to form phytosphinganine. Long-chain base analysis of the transformed mutant cells did not show any conversion of C(18)- or C(20)-sphinganine into Delta(8)-sphingenine, whereas exogenously added C(18)-phytosphinganine was desaturated to Delta(8)-trans/cis-phytosphingenine. Furthermore, GLC-MS analysis did not reveal the presence of any Delta(9)-regioisomers as reported before. These results show that the sunflower gene codes for a Delta(8)-sphingolipid desaturase which accepts C(18)- and C(20)-phytosphinganine. The absence of Delta(8)-sphingenine as desaturation product in the transformed mutant suggests that C(4)-hydroxylation of sphinganine precedes Delta(8)-desaturation. Therefore, in yeast, the substrate for the plant Delta(8)-sphingolipid desaturase seems to be the phytosphinganine residue.
Secure and efficient mobile agent application reuse using patterns (2001)

As wide-area open networks like the Internet and intranets grow larger, mobile agent technology is attracting more attention. Mobile agents are units of software that can deal with environmental changes and the various requirements of open networks through features such as autonomy, mobility, intelligence, cooperation, and reactivity. In addition, some people consider the agent technology as a promising solution to the reuse issue because of the aspect of the agents as highly adaptable software components. However, since the usual development methods of secure mobile agent applications are not sufficiently investigated, the technology is not yet widespread. In this paper, we propose a formal framework that supports mobile agent application development and reuse with consideration of the trade-offs between the security issues and the performance issues. In our framework, we design a mobile agent application by building a computational cost model and a security model, and combining patterns so that the combination satisfies the models. Therefore we can develop the application considering the security and the performance trade-offs. Since the models and the patterns are presented according to a formal framework, we can make sure that the pattern combination satisfies the models rigorously. In addition, if the security policy of the new environment is different from the old one in reusing the system in a new organization, we can easily modify and adapt the behavior because the pattern application can be figured out automatically by an algorithm.
Selectivity of 4,5,6,7‐tetrabromobenzotriazole, an ATP site‐directed inhibitor of protein kinase CK2 (‘casein kinase‐2’) (2001)

The specificity of 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase-2 (CK2), has been examined against a panel of 33 protein kinases, either Ser/Thr- or Tyr-specific. In the presence of 10 microM TBB (and 100 microM ATP) only CK2 was drastically inhibited (>85%) whereas three kinases (phosphorylase kinase, glycogen synthase kinase 3 beta and cyclin-dependent kinase 2/cyclin A) underwent moderate inhibition, with IC(50) values one--two orders of magnitude higher than CK2 (IC(50)=0.9 microM). TBB also inhibits endogenous CK2 in cultured Jurkat cells. A CK2 mutant in which Val66 has been replaced by alanine is much less susceptible to inhibition by TBB as well as by another ATP competitive inhibitor, emodin. These data show that TBB is a quite selective inhibitor of CK2, that can be used in cell-based assays.