gebhart/patrepeval huggingface dataset:
ENDOTHELIAL EFFECTS OF CHRONIC SILDENAFIL USE AMONG DIABETIC MEN (2008)

You have accessJournal of Urology1 Apr 2008ENDOTHELIAL EFFECTS OF CHRONIC SILDENAFIL USE AMONG DIABETIC MEN Ling Xu De Young, Walter Romano, Stephen E Pautler, KokBin Lim, Mussa Al-Numi, and Gerald B Brock Ling Xu De YoungLing Xu De Young More articles by this author , Walter RomanoWalter Romano More articles by this author , Stephen E PautlerStephen E Pautler More articles by this author , KokBin LimKokBin Lim More articles by this author , Mussa Al-NumiMussa Al-Numi More articles by this author , and Gerald B BrockGerald B Brock More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)61256-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "ENDOTHELIAL EFFECTS OF CHRONIC SILDENAFIL USE AMONG DIABETIC MEN." The Journal of Urology, 179(4S), p. 428 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 428 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Ling Xu De Young More articles by this author Walter Romano More articles by this author Stephen E Pautler More articles by this author KokBin Lim More articles by this author Mussa Al-Numi More articles by this author Gerald B Brock More articles by this author Expand All Advertisement PDF downloadLoading ...
Time-Lapse Elastic Inversion at the Oseberg Field (2002)

A-31 TIME-LAPSE ELASTIC INVERSION AT THE OSEBERG FIELD H. RUTLEDAL 1 R. ELDE 2 AND A-J. VAN WIJNGAARDEN 2 Introduction 1 The Oseberg Field is a major oil and gas field located in the North Sea some 140 km off the coast of Norway. The reservoir comprises sandstones from the Middle Jurassic Brent Group in three eastward-dipping tilted fault-blocks. The northernmost one Alpha North is focused upon in this study. The production from Alpha North started late 1991 with a two front production drive system; gas injection in the initial gas cap and water injection in the water leg. It
Estrogen Receptor (ER) Agonists Differentially Regulate Neuroangiogenesis in Peritoneal Endometriosis via the Repellent Factor SLIT3 (2014)

Endometriosis is an estrogen-dependent neurovascular disorder characterized by growth of endometrial tissue (lesions) outside the uterine cavity. Patients suffer chronic pelvic pain, and it has been proposed that co-recruitment of nerves/blood vessels (neuroangiogenesis) into the lesions is fundamental to the development of painful symptoms. We hypothesized that estrogen-dependent regulation of axonal guidance molecules of the SLIT/ROBO (Roundabout) family could play a role in neuroangiogenesis occurring in endometriosis lesions found on the peritoneal wall. In tissue samples from human patients and a mouse model of endometriosis, concentrations of mRNA encoded by SLIT3 were significantly higher in lesions than normal peritoneum. Estrogen regulation of SLIT3 was investigated using 17β-estradiol and selective agonists for each subtype of estrogen receptor (ER) (ERα agonist, 4,4',4″-(4-propyl-(1H)-pyrazole-1,3,5-tryl) trisphenol; ERβ agonist, 2,3-bis(4-hydroxy-phenyl)-propionitrile [DPN]). In mice, DPN (EC50 0.85) increased Slit3 mRNA concentrations compared with hormone-depleted and 17β-estradiol-treated (EC50 0.1) animals and decreased the density of nerves but not vessels in endometriosis lesions. SLIT3 mRNA concentrations were increased in DPN-treated human endometrial endothelial cells and in 4,4',4″-(4-propyl-(1H)-pyrazole-1,3,5-tryl) trisphenol-treated (EC50 200) rat dorsal root ganglia neurons. Functional assays (neurite outgrowth, network formation) revealed that SLIT3 promotes angiogenesis but decreases neurogenesis. In conclusion, these data suggest that estrogen-dependent expression of SLIT3 may play a key role in regulating nerve-vessel interactions within the complex microenvironment of endometriosis lesions.
Weight loss in nursing home patients: prognostic implications. (1990)

Weight loss is commonly used as a screening tool to assess quality of care and nutritional status in the nursing home setting. To evaluate the prognostic value of weight loss, the charts of 199 nursing home patients (414 nursing home patient years; mean age 87 years) were reviewed over a 3-year period. Weights recorded at nursing home admission and during the study period were compared with weights at the time of acute care hospitalization, transfer between levels of nursing home care, change in level of functional status, and death. There were no significant changes in weight before acute care hospitalizations, although patients who died lost an average of 10% of their body weight from the time of nursing home admission (P less than .001). In addition, weight loss was associated with decreased functional ability and transfer to a higher level of nursing home care. Despite the association of weight loss with subsequent morbidity and mortality, moderate weight loss of up to 20% was a poor predictor of mortality. Although weight loss is routinely used as a screening tool in the nursing home setting, it is not a sensitive marker for underlying disease. The efficacy of active intervention in nursing home patients who lose weight requires further study.
Evaluation of Mobility in Persons with Limb Loss Using the Amputee Mobility Predictor and the Prosthesis Evaluation Questionnaire–Mobility Subscale (2014)

This study is a retrospective chart review of standardized outcome measure data assessing mobility in persons with lower-limb loss. Patient charts were reviewed after the recent adoption of outcome measures as standard practice at a multiregion prosthetic practice. The study investigated the effects of amputation level and assigned activity level (K-level) on patient-perceived potential for mobility and functional ambulatory potential. The Amputee Mobility Predictor (AMP) and Prosthesis Evaluation Questionnaire–Mobility Subscale (PEQ-MS) scores were obtained and compared between transtibial and transfemoral patients and stratified by K-level. An analysis of variance (ANOVA) of AMP and PEQ-MS scores yielded significant variation (a = 0.05) for amputation K-levels. A Fisher protected least significant difference post hoc test found that the K3 and K4 groups had significantly higher AMP with prosthesis (AMPPRO) and PEQ-MS scores than those of the K2 group. The AMP and PEQ-MS scores were not found to be significantly different among transtibial and transfemoral amputation levels in the population studied. These two outcome measures have shown promise for differentiating K-level when adopted as standard practice in the clinical setting.
Parametric analysis of the communication satellite characteristics (2009)

Satellite communication has become an essential tool as part of the communication network globally. In order to define the capability of the communication satellite system, a parametric analysis in characterizing the key envelopes of the system requirement need to be established. Therefore, main characteristics such as mass, volume and power need to be identified in order to have a sense of understanding the type of satellite and system capacity that would be practical to be designed for. As the scope of the analysis being conducted was approaching from bus system perspective, the main characteristics would then being translated into analyzing the system capacity through assessment of the allowable payload envelope in the ranges of selected Launch Vehicle, deriving the propulsion system requirement, sizing the power system and describing the associated transponder capability which were the domain of interest in characterizing the satellite features. Results of the analysis would then encapsulate the ranges of feasible system requirement to be pursued further in the design phase.
TripleBit (2013)

The volume of RDF data continues to grow over the past decade and many known RDF datasets have billions of triples. A grant challenge of managing this huge RDF data is how to access this big RDF data efficiently. A popular approach to addressing the problem is to build a full set of permutations of (S, P, O) indexes. Although this approach has shown to accelerate joins by orders of magnitude, the large space overhead limits the scalability of this approach and makes it heavyweight. In this paper, we present TripleBit, a fast and compact system for storing and accessing RDF data. The design of TripleBit has three salient features. First, the compact design of TripleBit reduces both the size of stored RDF data and the size of its indexes. Second, TripleBit introduces two auxiliary index structures, ID-Chunk bit matrix and ID-Predicate bit matrix, to minimize the cost of index selection during query evaluation. Third, its query processor dynamically generates an optimal execution ordering for join queries, leading to fast query execution and effective reduction on the size of intermediate results. Our experiments show that TripleBit outperforms RDF-3X, MonetDB, BitMat on LUBM, UniProt and BTC 2012 benchmark queries and it offers orders of mangnitude performance improvement for some complex join queries.
Applications of Positron Emission Tomography in Neuropsychiatric Pharmaceutical Drug Development (2008)

Positron Emission Tomography (PET) can be used to quantify proteins of interest in the brain, assess the function of these proteins, and quantify cerebral glucose metabolism and blood flow. Its value in neuropsychiatric pharmaceutical drug development is extensive, from the identification of relevant pathophysiology in disease states, to measurement of blood-brain barrier penetration and regional cerebral occupancy of a pharmaceutical agent, to predictions of treatment outcome from a specific pharmacologic intervention in a specific patient. In this paper, we briefly review some basics of brain imaging using PET, and describe its applications to the field of neuropsychiatric pharmaceutical development, including relevant examples from the existing literature. We conclude with a discussion of future developments that will make PET increasingly available and useful for such purposes.
A model of the 1/fnoise in a forward-biased p–n diode (2007)

A model of 1/f noise in forward-biased p–n junction is suggested. The theory links current fluctuations to fluctuations of level occupancy in the density-of-states tail in the space charge region. The model is valid at forward biases for which the recombination current predominates. The 1/f (and 1/f-like) noise appears if the capture cross section of levels in the density-of-states tail decreases exponentially as the distance between a band edge and a level in the energy gap increases (multiphonon capture model). Analytical estimates for the frequency and current dependences of the 1/f noise are obtained.
An event-driven probabilistic model of sound source localization using cochlea spikes (2018)

This work presents a probabilistic model that estimates the location of sound sources using the output spikes of a silicon cochlea such as the Dynamic Audio Sensor. Unlike previous work which estimated the source locations directly from the interaural time differences (ITDs) extracted from the timing of the cochlea spikes, the spikes are used instead to support a distribution model of the ITDs representing possible locations of sound sources. Results on noisy single speaker recordings show average accuracies of approximately 80% on detecting the correct source locations and an estimation lag of <;100ms.
Mesostructural investigation of micron-sized glass particles during shear deformation – An experimental approach vs. DEM simulation (2017)

The interdependency of structure and mechanical features of a cohesive powder packing is on current scientific focus and far from being well understood. Although the Discrete Element Method provides a well applicable and widely used tool to model powder behavior, non-trivial contact mechanics of micron-sized particles demand a sophisticated contact model. Here, a direct comparison between experiment and simulation on a particle level offers a proper approach for model validation. However, the simulation of a full scale shear-tester experiment with micron-sized particles, and hence, validating this simulation remains a challenge. We address this task by down scaling the experimental setup: A fully functional micro shear-tester was developed and implemented into an X-ray tomography device in order to visualize the sample on a bulk and particle level within small bulk volumes of the order of a few micro liter under well-defined consolidation. Using spherical micron-sized particles (30 μm), shear tests with a particle number accessible for simulations can be performed. Moreover, particle level analysis allows for a direct comparison of experimental and numerical results, e.g., regarding structural evolution. In this talk, we focus on density inhomogeneity and shear induced heterogeneity during compaction and shear deformation.
Surgeons Learning Curve of Transforaminal Endoscopic Discectomy for Sciatica (2022)

PTED appears to be safe to be adopted by surgeons naïve to the procedure when they are initially supervised by an experienced senior surgeon. Duration of surgery and risk of repeated surgery are increased during the learning curve, but patient-reported outcomes of the early PTED cases are similar to the outcomes of later PTED cases, and similar to the outcomes of microdiscectomy cases. This study underlines the need for an experienced mentor for surgeons to safely adopt PTED.
Les nanocarbones fluorés : des additifs prometteurs pour la lubrification (2017)

International audience
Vitamin E Modulates Inflammatory Responses Induced by Cigarette Smoke (CS) Exposure in alpha ‐Tocopherol Transfer Protein (TTP) Null Mice (2006)

CS induced pulmonary inflammatory responses have been reported to be associated with oxidative stress and decreased levels of vitamin E (alpha‐tocopherol, a‐T), possibly due to increased utilization and turnover ( AJCN 2005; 81 :–103). In order to clarify possible vitamin E related modulations of inflammatory responses and oxidative stress we investigated the effects of a‐ and gamma (g)‐T on acute CS in mice with &lt; 10% of normal plasma and lung tissue a‐T levels due to a genetic defect of a‐tocopherol transfer protein (TTP KO). Mice (4 weeks old) were fed a‐ (35 mg/kg diet) or g‐T (1000 mg/kg diet) for 8–10 weeks and exposed to 60 mg/m3 CS, 6 hr/day for 3 days. Endpoints measured included a‐ &amp; g‐T levels, g‐T metabolites (g‐CEHC), inflammatory responses (IL‐1b, MIP‐2, MMP‐9 &amp; COX‐2) and oxidative stress markers (4‐HNE, HO‐1, CuZnSOD &amp; MnSOD). While a‐ &amp; g‐T levels were not changed, g‐CEHC levels were decreased after CS in both WT and TTP KO mice. HO‐1 and MnSOD were upregulated by CS as compared to air exposed WT and TTP KO mice. At basal level, HO‐1, MnSOD and MMP‐9 were increased in TTP KO mice as compared to WT mice. HO‐1, MnSOD, MMP‐9 and IL‐1b were upregulated when high g‐T diet was fed to WT and TTP KO mice either exposed air or CS. The results suggest that TTP KO mice are more susceptible to CS induced pulmonary inflammation and that vitamin E administration modulates these responses.
Export of metabolites by the proteins of the DMT and RhtB families and its possible role in intercellular communication (2006)

The earlier published and new experimental data are summarized on the properties of the genes encoding the membrane proteins of the DMT family (RhtA (YbiF), EamA (YdeD), YijE, YddG, YedA, PecM, eukaryotic nucleoside phosphate sugar and hexose phosphate transporters), the RhtB/LysE family (RhtB, RhtC, LeuE, YahN, EamB (YfiK), ArgO (YggA), CmaU), as well as some other families (YicM, YdhC, YdeAB, YdhE (NorE)). These proteins are involved in the export of amino acids, purines, and other metabolites from the cell. The expression of most of the genes encoding these proteins is not induced by the substrates they transport but is controlled by the global regulation systems, such as the Lrp protein, and activated by the signal compounds involved in the intracellular communication. The level of expression, assessed in experiments on translational fusion of the corresponding bacterial genes with the beta-galactosidase gene, depends on the growth phase of the bacterial culture, composition of the medium, and some stress factors, such as pH osmolarity or decreased aeration. The efflux of normal cell metabolites is assumed to be the natural function of these proteins. This function may play a role in density-dependent behavior of cell populations (quorum sensing). It may have been enhanced in the course of evolution via specialization of these proteins in the efflux of compounds derived from metabolic intermediates and adjusted to the role of transmitters.
Molecular cloning of a diverged homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells. (1993)

Adult vascular smooth muscle cells dedifferentiate and reenter the cell cycle in response to growth factor stimulation. Here we describe the molecular cloning from vascular smooth muscle, the structure, and the chromosomal location of a diverged homeobox gene, Gax, whose expression is largely confined to the cardiovascular tissues of the adult. In quiescent adult rat vascular smooth muscle cells, Gax mRNA levels are down-regulated as much as 15-fold within 2 h when these cells are induced to proliferate with platelet-derived growth factor (PDGF) or serum growth factors. This reduction in Gax mRNA is transient, with levels beginning to rise between 8 and 24 h after mitogen stimulation and returning to near normal by 24 to 48 h. The Gax down-regulation is dose dependent and can be correlated with the mitogen's ability to stimulate DNA synthesis. PDGF-AA, a weak mitogen for rat vascular smooth muscle cells, did not affect Gax transcript levels, while PDGF-AB and -BB, potent mitogens for these cells, were nearly as effective as fetal bovine serum. The removal of serum from growing cells induced Gax expression fivefold within 24 h. These data suggest that Gax is likely to have a regulatory function in the G0-to-G1 transition of the cell cycle in vascular smooth muscle cells.
A novel method for quantifying arm motion similarity (2015)

This paper proposes a novel task-independent method for quantifying arm motion similarity that can be applied to any kinematic/dynamic variable of interest. Given two arm motions for the same task, not necessarily with the same completion time, it plots the time-normalized curves against one another and generates four real-valued features. To validate these features we apply them to quantify the relationship between healthy and paretic arm motions of chronic stroke patients. Studying both unimanual and bimanual arm motions of eight chronic stroke patients, we find that inter-arm coupling that tends to synchronize the motions of both arms in bimanual motions, has a stronger effect at task-relevant joints than at task-irrelevant joints. It also revealed that the paretic arm suppresses the shoulder flexion of the non-paretic arm, while the latter encourages the shoulder rotation of the former.
A Volume Averaged Finite-Volume Model for Solidification of Magnesium Alloys on a General Unstructured Collocated Grid (2014)

A formulation used to simulate the solidification process of magnesium alloys is developed based upon the volume-averaged finite-volume method on unstructured collocated grids. In casting the single equation formulation, a non-zero volume fraction gradient has been considered, and resulting additional terms are well reasoned. For discretization, the most modern approximations for gradients and hessians are used and novelties are outlined. The formulation is tested for a wedge-shaped magnesium alloy casting to predict the cooling curves and the grain size at six embedded thermocouples. The current predictions compare well against previously reported experimental results.
Sodium Thiosulphate as a Promising Therapeutic Option to Treat Calciphylaxis (2006)

A 35-year-old haemodialysis-dependent woman with chronic renal failure developed large, very painful necrotic ulcers and necrosis on the thighs, buttocks and the abdomen with signs of fast progression. The skin biopsy specimens showed a broad necrosis of the epidermis and thrombosed dermal vessels with focal calcium deposits within the wall. In addition, laboratory findings presented an increased product of serum calcium and phosphate concentrations. Thus, we diagnosed calciphylaxis on the basis of clinical, biochemical and histopathological criteria. We initiated a therapy in which our patient was treated with intravenous sodium thiosulphate 3 times weekly. Already after 2 weeks of treatment, no new lesions were detectable and there was a dramatic pain relief. In the following 4 weeks, a successive decline of the ulcers and the healing of individual tissue defects could be seen. Four months after the start of the therapy, the patient underwent successful renal transplantation. Thus, the intravenous therapy of calciphylaxis with sodium thiosulphate might be a new effective alternative in the treatment of this life-threatening disease.
Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors (2018)

DNA sequence and epigenetic information embedded in chromatin must be faithfully duplicated and transmitted to daughter cells during cell division. However, how chromatin assembly and DNA replication are integrated remains unclear. We examined the contribution of the Tousled-like kinases 1 and 2 (TLK1/TLK2) to chromatin assembly and maintenance of replication fork integrity. We show that TLK activity is required for DNA replication and replication-coupled nucleosome assembly and that lack of TLK activity leads to replication fork stalling and the accumulation of single-stranded DNA, a phenotype distinct from ASF1 depletion. Consistent with these results, sustained TLK depletion gives rise to replication-dependent DNA damage and p53-dependent cell cycle arrest in G<sub>1</sub>. We find that deficient replication-coupled de novo nucleosome assembly renders replication forks unstable and highly dependent on the ATR and CHK1 checkpoint kinases, as well as poly(adenosine 5'-diphosphate-ribose) polymerase (PARP) activity, to avoid collapse. Human cancer data revealed frequent up-regulation of <i>TLK</i> genes and an association with poor patient outcome in multiple types of cancer, and depletion of TLK activity leads to increased replication stress and DNA damage in a panel of cancer cells. Our results reveal a critical role for TLKs in chromatin replication and suppression of replication stress and identify a synergistic lethal relationship with checkpoint signaling and PARP that could be exploited in treatment of a broad range of cancers.
Measurement of Erythema and Tanning Responses in Human Skin Using a Tri-Stimulus Colorimeter (1988)

A 'Minolta Tri-Stimulus Colorimeter II' was evaluated for obtaining objective measurements of early changes in erythema and tanning. The meter showed a subtle, continuous transition between the primary erythematous response and the delayed tanning of skin which was below the visual threshold for detection. Thereafter, the a* (redness) value of the meter showed a significant linear correlation with the dermatologist's perception of erythema while the b* (yellow) value showed a significant correlation with the perception of tanning. This capability of the tri-stimulus colorimeter to simultaneously evaluate the hue and saturation of skin color affords an improved opportunity to quantitate the transition from erythema to tanning without subjective bias.