gebhart/patrepeval huggingface dataset:
Location of histone lysyl residues modified by in vitro acetylation of chromatin (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLocation of histone lysyl residues modified by in vitro acetylation of chromatinLois O. Tack and Robert T. SimpsonCite this: Biochemistry 1979, 18, 14, 3110–3118Publication Date (Print):July 10, 1979Publication History Published online1 May 2002Published inissue 10 July 1979https://pubs.acs.org/doi/10.1021/bi00581a031https://doi.org/10.1021/bi00581a031research-articleACS PublicationsRequest reuse permissionsArticle Views62Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New hole transporting materials for planar perovskite solar cells (2018)

Two new hole transporting materials (HTMs) based on triphenylamine and carbazole core moieties are designed and applied in planar perovskite solar cells. 18.2% power conversion efficiency (PCE) has been achieved, and 84% of the initial performance can be retained after 50 days.
Self‐Assembling Structures of Long‐Chain Sugar‐Based Amphiphiles Influenced by the Introduction of Double Bonds (2005)

Nine phenyl glucoside or galactoside amphiphiles possessing a saturated or unsaturated long alkyl-chain group as the self-assembling unit of a highly organized molecular architecture were synthesized. Their self-assembly properties were investigated by using energy-filtering TEM (EF-TEM), SEM, CD, XRD, and FT-IR techniques. Compound 2, possessing one cis double bond in the lipophilic portion, exhibited twisted helical fibers, which formed a bilayered structure with a 3.59 nm period, while 3 exhibited helical ribbons and left-handed nanotubular structures with 150-200 nm inner diameters and a wall thickness of approximately 20 nm. Very interestingly, 4, possessing three cis double bonds, exhibited a nanotubular structure with an inner diameter of approximately 70 nm and a d spacing value of 4.62 nm. On the other hand, 7, possessing two trans double bonds in the lipophilic region, exhibited crystal- or plate-like structures, which formed a bilayer structure with a d spacing value of 3.93 nm. These results indicate that the self-assembly properties are strongly dependent on the type of double bond. Furthermore, 8 and 9, with the galactopyranose moiety, revealed helical ribbon and well-defined double helical fiber structures, respectively. These findings support the view that the orientation of the intermolecular hydrogen-bonding interaction between the sugar moieties plays a critical role in producing the nanotubular structures. According to CD and powder XRD experiments, the relatively strong intermolecular hydrogen-bonding interaction of the glucopyranoside moiety in 3 and 4 provided a highly ordered chiral packing structure. Even though these compounds formed a weak hydrophobic interaction between lipophilic groups, it led to the formation of the nanotubular structure.
Aspects of socialization (1995)

Socialization is the process that commences from birth onwards whereby we learn the norms expected in our society. Within any given culture there exists an unwritten set of guidelines for various behaviours, such as those involving morality, aggression and the different roles assigned to the sexes.
Kalkulierte parenterale Initialtherapie bakterieller Infektionen: Bakterielle Endokarditis (2020)

This is the twelfth chapter of the guideline "Calculated initial parenteral treatment of bacterial infections in adults - update 2018" in the 2<sup>nd</sup> updated version. The German guideline by the Paul-Ehrlich-Gesellschaft für Chemotherapie e.V. (PEG) has been translated to address an international audience. The bacterial endocarditis is characterised by a constant incidence but a shift in the patient population due to the use of prosthetic heart valves and foreign materials like pacemakers and the increasing application of invasive medical procedures. This is linked to a change in the predominant infecting organisms towards staphylococci. This chapter gives recommendations for the interdisciplinary management of infective endocarditis from the diagnostic workup over prevention to therapy with a focus on antibiotic therapy.
A HDL-independent modeling methodology for heterogeneous system designs (2005)

This paper introduces a description methodology to be used in heterogeneous, multi-HDL (hardware description language) system designs. Complex microelectronic embedded systems contain more and more concurrently designed subsystems, which are mostly coded in different HDLs to get best model performances. Verification of all subsystems in one environment represents a difficult task. This paper focuses on a HDL-independent description methodology, which enables a description of models coded in different HDLs using the same language semantic. Moreover, it supports a verification methodology for heterogeneous systems based on a cosimulation using standard EDA tools. The proposed description methodology has been applied on an application framework for heterogeneous system verification and later on evaluated by an example taken from the automotive industry.
Stochasticity and the Molecular Mechanisms of Induced Pluripotency (2008)

The generation of induced pluripotent stem cells from adult somatic cells by ectopic expression of key transcription factors holds significant medical promise. However, current techniques for inducing pluripotency rely on viral infection and are therefore not, at present, viable within a clinical setting. Thus, there is now a need to better understand the molecular basis of stem cell pluripotency and lineage specification in order to investigate alternative methods to induce pluripotency for clinical application. However, the complexity of the underlying molecular circuitry makes this a conceptually difficult task. In order to address these issues, we considered a computational model of transcriptional control of cell fate specification. The model comprises two mutually interacting sub-circuits: a central pluripotency circuit consisting of interactions between stem-cell specific transcription factors OCT4, SOX2 and NANOG coupled to a differentiation circuit consisting of interactions between lineage-specifying master genes.The molecular switches which arise from feedback loops within these circuits give rise to a well-defined sequence of successive gene restrictions corresponding to a controlled differentiation cascade in response to environmental stimuli. Furthermore, we found that this differentiation cascade is strongly unidirectional: once silenced, core transcription factors cannot easily be reactivated. In the context of induced pluripotency, this indicates that differentiated cells are robustly resistant to reprogramming to a more primitive state. However, our model suggests that under certain circumstances, amplification of low-level fluctuations in transcriptional status (transcriptional "noise") may be sufficient to trigger reactivation of the core pluripotency switch and reprogramming to a pluripotent state. This interpretation offers an explanation of a number of experimental observations concerning the molecular mechanisms of cellular reprogramming by defined factors and suggests a role for stochasticity in reprogramming of somatic cells to pluripotency.
An Efficient Laboratory Matching and Screening Method for Antifouling Substances Using the Blue Mussel,Mytilus edulis, and an Antimicrobial Assay (1992)

Many compounds with attaching repellent activity in the blue mussel assay also showed antifouling activity in the conventional submerged assay. Only those attaching repellents with antimicrobial activity against marine Gram-positive bacteria isolated from slime, as well as Staphylococcus aureus, Bacillus suhtilis, Trichophyton mentagrophytes, and Candida alhicans exhibited antifouling activity. A combination of the blue mussel and antimicrobial assays is suggested to be a simple and efficient screening procedure for antifouling substances.
A new series of mixed-valence lithium titanium(III/IV) phosphates, Li1+xTi2(PO4)3 (0 .ltoreq. x .ltoreq. 2), with NASICON-related structures (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new series of mixed-valence lithium titanium(III/IV) phosphates, Li1+xTi2(PO4)3 (0 .ltoreq. x .ltoreq. 2), with NASICON-related structuresShumin Wang and Shiou Jyh HwuCite this: Chem. Mater. 1992, 4, 3, 589–595Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/cm00021a018https://doi.org/10.1021/cm00021a018research-articleACS PublicationsRequest reuse permissionsArticle Views261Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation (2000)

Tangeretin is a potent regioselective stimulator of midazolam 1'-hydroxylation by human liver microsomes and complementary deoxyribonucleic acid-expressed CYP3A4. However, tangerine juice is unlikely to have any appreciable effect on CYP3A4 in humans. Further studies are required to assess whether in vitro stimulators of CYP3A4 can influence drug metabolism in vivo.
Hybrid Unmanned Aerial Underwater Vehicle: Modeling and simulation (2014)

The complete modeling and simulation of an unmanned vehicle with combined aerial and underwater capabilities, called Hybrid Unmanned Aerial Underwater Vehicle (HUAUV), is presented in this paper. The best architecture for this kind of vehicle was evaluated based on the adaptation of typical platforms for aerial and underwater vehicles, to allow the navigation in both environments. The model selected was based on a quadrotor-like aerial platform, adapted to dive and move underwater. Kinematic and dynamic models are presented here, and the parameters for a small dimension prototype was estimated and simulated. Finally, controllers were used and validated in realistic simulation, including air and water navigation, and the environment transition problem. To the best of our knowledge, it is the first vehicle that is able to navigate in both environment without mechanical adaptation during the medium transitions.
The Leishmania ARL-1 and Golgi Traffic (2008)

We present here the characterisation of the Leishmania small G protein ADP-Ribosylation Factor-Like protein 1 (ARL-1). The ARL-1 gene is present in one copy per haploid genome and conserved among trypanosomatids. It encodes a protein of 20 kDa, which is equally expressed in the insect promastigote and mammalian amastigote forms of the parasite. ARL-1 localises to the Trans-Golgi Network (TGN); N-terminal myristoylation is essential for TGN localisation. In vivo expression of the LdARL-1/Q74L and LdARL-1/T51N mutants (GTP- and GDP-bound blocked forms respectively) shows that GDP/GTP cycling occurs entirely within the TGN. This is contrary to previous reports in yeast and mammals, where the mutant empty form devoid of nucleotide has been considered as the GDP-blocked form. The dominant-negative empty form mutant LdARL-1/T34N inhibits endocytosis and intracellular trafficking from the TGN to the Lysosome/Multivesicular Tubule and to the acidocalcisomes; these defects are probably related to a mislocalisation of the GRIP domain-containing vesicle tethering factors which cannot be recruited to the TGN by the cytoplasmic LdARL-1/T34N. Thus, besides the functional characterization of a new mutant and a better understanding of ARL-1 GDP/GTP cycling, this work shows that Leishmania ARL-1 is a key component of an essential pathway worth future study.
The pelota locus encodes a protein required for meiotic cell division: an analysis of G2/M arrest in Drosophila spermatogenesis (1995)

During Drosophila spermatogenesis, germ cells undergo four rounds of mitosis, an extended premeiotic G2 phase and two meiotic divisions. In males homozygous for mutations in pelota, the germline mitotic divisions are normal, but the cell cycle arrests prior to the first meiotic division; pelota males are therefore sterile. Chromosomes begin to condense in these mutants, but other meiotic processes, including nuclear envelope breakdown and spindle formation, do not occur. The arrest phenotype closely resembles that of mutations in the Drosophila cdc25 homolog twine. Although meiosis is blocked in pelota and twine homozygotes, spermatid differentiation continues. pelota is also required for patterning in the eye and mitotic divisions in the ovary. We have cloned the pelota locus and show it encodes a 44 x 10(3) M(r) protein with yeast, plant, worm and human homologs.
Sound and Quasi-Complete Detection of Infeasible Test Requirements (2015)

In software testing, coverage criteria specify the requirements to be covered by the test cases. However, in practice such criteria are limited due to the well-known infeasibility problem, which concerns elements/requirements that cannot be covered by any test case. To deal with this issue we revisit and improve state-of-the-art static analysis techniques, such as Value Analysis and Weakest Precondition calculus. We propose a lightweight greybox scheme for combining these two techniques in a complementary way. In particular we focus on detecting infeasible test requirements in an automatic and sound way for condition coverage, multiple condition coverage and weak mutation testing criteria. Experimental results show that our method is capable of detecting almost all the infeasible test requirements, 95% on average, in a reasonable amount of time, i.e., less than 40 seconds, making it practical for unit testing.
ChemInform Abstract: Micelles in Organic Synthesis: Aldol Reactions in Aqueous Micelles of Cetyltrimethylammonium Bromide. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Characterization and model-based design validation of 3D printed cookies (2017)

Additive manufacturing is revolutionizing processing in many applications including 3D food printing. A Fused Deposition Modelling printing method was developed to produce cookies. In order to design food of particular texture, a fine element model was established to predict the mechanical properties of structured products. Cookie structures were engineered to achieve desirable texture properties in silico and dedicated print files were created for 3D printing. In order to validate the model, the properties of the printed cookies were measured and analysed. Compression tests were performed to determine Young’s modulus. X-ray micro-CT imaging was applied to characterize the 3D microstructure of the printed cookies samples. Micro-CT imaging provided a better understanding about the effects of the 3D printing process on cookie structure. Finally, a better fit of the prediction model was obtained by adjusting the model geometry to the scanned printed structure, which indicates the importance of structure integrity for mechanical properties of printed cookies.
Modeling Trust in Online Social Networks to Improve Adolescent Health Behavior (2010)

One of the major public health findings in recent years has been the discovery of the strong impact of an individual's social network on the individual's health as well as habits. A number of studies have shown that physical health factors such as obesity, emotional health factors such as happiness, and habits such as smoking and exercise are significantly impacted by the individual's social network. Based on this, there has been increasing interest in the application of network theory and system dynamics to the study of public health.&#13;\n&#13;\nAmong a range of public health issues, adolescent health is particularly important for a number of reasons. First, given their developmental stage, adolescents are particularly sensitive to, and impacted by, their social networks. Second, many lifelong health habits or risk behaviors are established during adolescence (e.g. cigarette smoking, alcohol use). Third, adolescents represent the future workforce of the nation, thus their long-term health is critically important for the economy. This makes it especially important to study the impact of social networks on adolescent health.&#13;\n&#13;\nWhile the invention of the Internet, Web, mobile phones and personal digital assistants have revolutionized many walks of life, the most relevant to our present discussion is the creation of various online social networking sites (e.g. Facebook, MySpace, Twitter). These sites allow new forms of person-to-person interactions, with negligible cost, low latency, and high bandwidth; with the overall effect being one of dramatically increasing the intensity and continuity of communication between people. Many end up spending more attention on online social networks, often at the expense of face-to-face interaction. While this 'attention displacement' from the physical world to the online world potentially raises interesting socio-psychological questions on its own, the fact that the online world is having a significant impact on our lives is unquestioned. Given that usage of online social networking sites is growing at a very rapid rate among adolescents, essentially having become a de facto socialization mechanism in this age group, its impact on adolescent health is expected to be commensurately high, and thus a correspondingly important area of inquiry.&#13;\n&#13;\nWhile on the one hand the new information and communication technologies have created the tools for new means (and kinds) of socialization, as a complement, the tremendous data collection abilities of these very same technologies provide a perfect opportunity to study these socializations at a granularity which was previously unimaginable. Use of advanced computational methods to analyze detailed behavioral data is bringing about a revolution in the way social science questions can be studied, and has led to the rapid emergence of the discipline of computational social science.&#13;\n...&lt;br /&gt;[NOTE - Abstract continues in actual report]
BETTER THAN MINT (2007)

RETURN TO ISSUEPREVNewsNEXTBETTER THAN MINTACS MEETING NEWS: Medicinal chemistry methods lead to new cooling compounds that are more potent and last longer than mentholSOPHIE L. ROVNERView Author Information C&EN WASHINGTONCite this: Chem. Eng. News 2007, 85, 39, 95Publication Date (Print):September 24, 2007Publication History Published online29 October 2010Published inissue 24 September 2007https://pubs.acs.org/doi/10.1021/cen-v085n039.p095https://doi.org/10.1021/cen-v085n039.p095newsACS PublicationsCopyright © 2007 American Chemical SocietyArticle Views33Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Flavor,Manufacturing,Neurophysiology,Plants,Quality management Get e-Alerts
A novel germline mutation in CDK4 codon 24 associated to familial melanoma (2017)

Germline mutations of the CDK4 gene have been reported in 18 familial cutaneous melanoma (CM) cases worldwide, with only 2 substitutions, the c.70C&amp;gt;T,p.Arg24Cys and c.71G&amp;gt;A,p.Arg24His, described to date. Moreover, the acquired CDK4 p.Asn41Ser variant has been related to sporadic metastatic malignant melanoma. we report the molecular studies of a familial case of CM carrying the new germline CDK4 c.71G&amp;gt;T,p.Arg24Leu. modulators.
Age‐related differences in testicular microcirculation (1990)

Different aspects of testicular microcirculation were studied in rats aged 20, 24 or 90 days, in order to determine if maturational changes in the testis could influence its vasculature. Using laser Doppler flowmetry, it was found that vasomotion was not present in 20-day-old rats, but it could be induced by hCG-treatment given 32 h prior to flow measurements. In rats aged 24 days vasomotion was present in the testis but it was not influenced by hCG treatment, in contrast to adult rats in which testicular vasomotion disappeared after hCG treatment. In all age-groups, hCG treatment induced an increase in testicular interstitial fluid (IF) volume, which was most pronounced in young rats. In young rats, as in adults, there was an increase in the volume density of polymorphonuclear (PMN) leucocytes in testicular blood vessels after hCG treatment. However, rats aged 20 or 24 days did not exhibit any significant extravascular migration of leucocytes as occurred in adult rat testis after hCG injection. The deposition of colloidal carbon particles observed in adult rats after hCG-treatment was also not seen in young rats. It is concluded that the vasculature of the immature rat testis responds to hCG stimulation with an increase in IF volume. However, when compared to adult rats, different mechanisms may be operating because no evidence for opening of inter-endothelial cell gaps was observed in the testis of young rats.
The non-uniformity of imaging devices and its impact in quantitative studies (1977)

info:eu-repo/semantics/published