gebhart/patrepeval huggingface dataset:
Modelling of a MEMS-based microgripper: application to dexterous micromanipulation (2010)

MEMS-based microgrippers with integrated force sensor have proved their efficiency to perform dexterous micromanipulation tasks through gripping forces sensing and control. For force control, knowledge based models are more relevant and gives better physical significance than the use of black box models. However this approach is often limited by many problems commonly encountered in the MEMS (micro electromechanical systems) structures such as: complex architectures, nonlinear behaviors and parameters uncertainties due to fabrication process at the micrometer scale. For these reasons theoretical approaches must be compared with experiments. This paper describes a modelling approach of a MEMS-based microgripper with integrated force sensor while handling micro-glass balls of 80μm diameter. Therefore, a state space representation is developed to couple both the dynamics of the actuation and sensing subsystems of the gripper through the stiffness of the manipulated object. A knowledge based model is obtained for small displacements at the tip of the gripper arms (small gripping forces) and is compared with experimental approaches. Good agreements are observed allowing interesting perspectives for the control.
Impact of power uprate on environmental qualification of equipment in nuclear power plants (2002)

Many nuclear power facilities are finding it economically beneficial to increase reactor output, from operating plants, by resorting to power uprates. A power uprate implies that a utility can increase the reactor output, or the megawatts generated, by increasing steam pressure without adding or changing any plant systems. This is perhaps one of the least expensive options for increasing the generating capacity of a power plant. However, a nuclear plant requires a comprehensive review of the plant systems, structures and components to assure their capability to withstand the resulting increased normal and accident plant conditions. A power uprate will typically result in a plant operating at higher than the originally designed environmental conditions. Safety related equipment in nuclear plants is presently qualified to the UFSAR Chapter 15 accident events and the resulting temperatures, pressures, radiation levels etc. These values will increase when the reactor is producing a higher MWe output. Components that are sensitive to the environment must be re-evaluated and assessed to determine their acceptability and operability under the revised environmental conditions. Most safety-related mechanical and electrical equipment will require an assessment from an environmental qualification standpoint. Utilities must perform this task in a systematic, auditable and cost effective manner to optimize their resources and minimize plant costs associated with modifications, replacements or equipment testing. This paper discusses various approaches and provides recommendations to achieve equipment qualification while satisfying the plant's objective of a power uprate.
Low leaf hydraulic conductance associated with drought tolerance in soybean (2007)

Lack of water is the most serious environmental constraint on agricultural production. More efficient use of water resources is a key solution for increased plant productivity in water-deficit environments. We examined the hydraulic characteristics of a 'slow wilting' phenotype in soybean (Glycine max Merr.), PI 416937, which has been shown to have relatively constant transpiration rates above a threshold atmospheric vapor pressure deficit (VPD). The VPD response of PI 416937 was confirmed. Three experiments are reported to examine the hypothesis that the VPD response was a result of low hydraulic conductance in leaves as compared to two other soybean genotypes. Results are reported from experiments to measure transpiration response to VPD when xylem water potential was maintained at zero, leaf rehydration response and leaf carbon assimilation response to petiole cutting. Major interspecific differences in leaf hydraulic properties were observed. The observed low leaf hydraulic conductance in PI 416937 is consistent with an increased water use efficiency, and an increased water conservation by limiting transpiration rates under high evaporative conditions but allowing normal gas exchange rates under more moderate evaporative conditions.
Defect-induced overshoot of quantum Hall plateaus (2000)

Studies on magnetoresistance in the quantum Hall regime show that defects induced by proton irradiation strongly change the transport properties of an AlGaAs/GaAs two-dimensional electron gas. In particular, it is shown that the overshoot of the quantized value of the Hall resistance at odd filling factors can be introduced by these defects. A model, that explains the observation and assumes that the defects which have spins are essential for mediating the electron scattering in the two-dimensional electron gas, is presented.
Structural transformations of heat treated Co-less high entropy alloys (2018)

Co is considered to be one of the main ingredients in superalloys. Co is considered a critical element and its substitution is difficult due to its unique ability to form high temperature stable structures with high mechanical and corrosion/oxidation resistance. High entropy alloys (HEA) represent a relatively new concept in material design. HEA are characterised by a high number of alloying elements, in unusually high proportion. Due to their specific particularities, high entropy alloys tend to form predominant solid solution structures that develop potentially high chemical, physical and mechanical properties. Present paper is studying Co-less high entropy alloys with high potential in severe environment applications. The high entropy alloys based on Al-Cr-Fe-Mn-Ni system were prepared by induction melting and casting under protective atmosphere. The as-cast specimens were heat treated at various temperatures to determine the structure and property behaviour. Samples taken before and after heat treatment were investigated for chemical, physical, structural and mechanical characteristics. Sigma phase composition and heat treatment parameters had major influence over the resulted alloy structure and properties. © Published under licence by IOP Publishing Ltd.
Processing of von Willebrand Factor by ADAMTS-13 (2002)

ADVERTISEMENT RETURN TO ISSUECurrent Topics/Persp...Current Topics/PerspectivesNEXTProcessing of von Willebrand Factor by ADAMTS-13†Dominic W. Chung and Kazuo FujikawaView Author Information Department of Biochemistry, University of Washington, Seattle, Washington 98195 Cite this: Biochemistry 2002, 41, 37, 11065–11070Publication Date (Web):August 15, 2002Publication History Received11 July 2002Published online15 August 2002Published inissue 1 September 2002https://pubs.acs.org/doi/10.1021/bi0204692https://doi.org/10.1021/bi0204692review-articleACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views299Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biopolymers,Cells,Peptides and proteins,Plasma,Polymers Get e-Alerts
The Novel Role of SERPINB9 in Cytotoxic Protection of Human Mesenchymal Stem Cells (2011)

Clinical trials using allogeneic mesenchymal stem cells (MSCs) are ongoing for the purpose of providing therapeutic benefit for a variety of human disorders. Pertinent to their clinical use are the accessibility to sufficient quantities of these cells allowing for repetitive administration, as well as a better understanding of the specific mechanisms by which allogeneic MSCs evade host immune responses that in turn influence their life span following administration. In this report, we sought to characterize and compare human peripheral blood MSCs (hPB-MSCs) with bone marrow-derived MSCs. hPB-MSCs met the established criteria to characterize this cellular lineage, including capacity for self-renewal, differentiation into tissues of mesodermal origin, and expression of phenotypic surface markers. In addition, hPB-MSCs suppressed alloreactive proliferation as well as the production of proinflammatory cytokines. Examination of the mechanisms by which allogeneic MSCs evade the host immune response, which is crucial for their therapeutic use, demonstrated that constitutive expression of serine protease inhibitor 9 (PI-9) on hPB-MSCs and bone marrow-derived MSCs is a major defense mechanism against granzyme B-mediated destruction by NK cells. Similarly, MSCs treated with small interfering RNA for PI-9 increased MSC cellular death, whereas expression of transgenic PI-9 following retroviral transduction protected MSCs. These data significantly advance our understanding of the immunomodulatory role for hPB-MSCs as well as the mechanisms by which they evade host immune responses. These findings contribute to the development of MSC-based therapies for diseases.
Relations internationales et expérience américaine : le voyage au bout de la nuit des étudiants montréalais aux États-Unis (1947-1955) (2021)

Cet article porte sur une série de rencontres qui ont eu lieu de 1947 à 1955 entre les étudiants de l’Université de Montréal et leurs confrères américains dans différentes villes de part et d’autre de la frontière. À l’occasion des événements organisés par les Clubs des relations internationales (CRI), les Udémiens se sont transformés en ambassadeurs patentés du Québec à l’étranger et ont par la suite raconté en détail leurs aventures. Leur « moment américain » a bousculé plusieurs de leurs représentations et les a incités à explorer de nouvelles avenues pour articuler le rôle de la jeunesse, l’expérience du temps propre au Canada français et la mission de l’université francophone en Amérique. Je montre que l’approche critique qu’ont adoptée les Udémiens par rapport aux discours de leurs aînés et particulièrement de leurs professeurs, tout en leur ouvrant un espace discursif propre, tenait justement à cette remise en jeu de certaines idées reçues par l’affirmation d’un enracinement en Amérique qui mettait en valeur, mais pour mieux les projeter dans le futur, l’exception(nalité) canadienne-française et son patrimoine culturel européen et français.
A framework for femtocells to access both licensed and unlicensed bands (2011)

Cellular operators have been offloading data traffic from their licensed bands to unlicensed bands through a large number of WiFi hotspots over the past years. Although this approach improves the cellular network capacity to some extent, it falls short of getting significant throughput gains. In this paper, it is argued that femtocells, covering a short range, can be a perfect platform to jointly exploit the merits of both licensed and unlicensed frequency bands. In particular, a framework is proposed for a femtocell to simultaneously access both licensed and unlicensed bands. The performance of coexisting femtocell and WiFi networks operating over a fully-utilized unlicensed band are analytically modeled and are verified via simulations. Impact of femtocell channel access parameters on the performance of WiFi and cellular networks is also investigated, shedding light on how a femtocell can best adjust its channel access parameters to coexist with incumbent unlicensed spectrum users like WiFi networks.
Generation of 10^11 contrast 50 TW laser pulses (2006)

We demonstrate what we believe to be the highest-contrast (10(11)), multiterawatt, chirped-pulse amplification (CPA) Ti:sapphire laser by applying the modified cross-polarized-wave (XPW) generation method. This method produces a contrast improvement of 3 orders of magnitude using microjoule input energy. Microjoule energy can be achieved by direct amplification without the complications of a double CPA system. The 10(11) contrast is sufficient for experiments on high-damage-threshold solid targets with focused intensities up to 10(22) W/cm(2).
An extendable modular endoprosthetic system for bone tumour management in the leg (1990)

A modular endoprosthetic system has been developed at the Groningen University Hospital and the University of Twente. The system can bridge a defect resulting from the resection of a malignant bone tumour which has developed around the knee joint of a child. Since the other healthy leg continues to grow, the system includes an element whose length can be adjusted non-invasively by using an external magnetic field. In addition to this lengthening element, there are one hip and two knee components, connectors of various lengths, and fixation elements. The paper describes the elements of the modular endoprosthetic system. Tables are created by means of which the elemental composition of such an endoprosthesis can be determined for each individual patient.
Selective internalization of self-assembled artificial oil bodies by HER2/neu-positive cells (2010)

A novel delivery carrier was developed using artificial oil bodies (AOBs). Plant seed oil bodies (OBs) consist of a triacylglycerol matrix surrounded by a monolayer of phospholipids embedded with the storage protein oleosin (Ole). Ole consists of a central hydrophobic domain with two amphiphatic arms that extrude from the surface of OBs. In this study, a bivalent anti-HER2/neu affibody domain (ZH2) was fused with Ole at the C terminus. After overproduction in Escherichia coli, the fusion protein (Ole-ZH2) was recovered to assemble AOBs. The size of self-assembled AOBs was tailored by varying the oil/Ole-ZH2 ratio and pH to reach a nanoscale. Upon co-incubation with tumor cells, the nanoscale AOBs encapsulated with a hydrophobic fluorescence dye were selectively internalized by HER2/neu-overexpressing cells and displayed biocompatibility with the cells. In addition, the ZH2-mediated endosomal entry of AOBs occurred in a time- and AOB dose-dependent manner. The internalization efficiency was as high as 90%. The internalized AOBs disintegrated at the non-permissive pH (e.g. in acidic endosomes) and the cargo dye was released. Results of in vitro study revealed a sustained and prolonged release profile. Taken together, our findings indicate the potential of AOBs as a delivery carrier.
Data from Safety, Pharmacokinetics, and Pharmacodynamics of AMG 102, a Fully Human Hepatocyte Growth Factor–Neutralizing Monoclonal Antibody, in a First-in-Human Study of Patients with Advanced Solid Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The aims were to assess the safety, pharmacokinetics, maximum tolerated dose, and antitumor activity of AMG 102, a fully human hepatocyte growth factor/scatter factor (HGF/SF)–neutralizing monoclonal antibody, in patients with solid tumors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Patients (&lt;i&gt;N&lt;/i&gt; = 40) with refractory advanced solid tumors were enrolled into six sequential dose-escalation cohorts (0.5, 1, 3, 5, 10, or 20 mg/kg AMG 102 i.v. every 2 weeks) and a dose-expansion cohort (20 mg/kg AMG 102 every 2 weeks). Safety, anti–AMG 102 antibody formation, pharmacokinetics, tumor response, and exploratory biomarkers were assessed.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; AMG 102 was well tolerated up to the planned maximum dose of 20 mg/kg, and the maximum tolerated dose was not reached. Treatment-related adverse events were generally mild and included fatigue (13%), constipation (8%), nausea (8%), vomiting (5%), anorexia (5%), myalgia (5%), and hypertension (5%). Two patients experienced dose-limiting toxicities: one patient (0.5 mg/kg cohort) experienced grade 3 hypoxia and grade 3 dyspnea and one patient (1 mg/kg cohort) experienced grade 3 upper gastrointestinal hemorrhage. No anti–AMG 102 antibodies were detected, and AMG 102 had linear pharmacokinetics within the dose range investigated. Sixteen of 23 (70%) evaluable patients had a best response of stable disease with progression-free survival ranging from 7.9 to 40 weeks. Circulating levels of the biomarker HGF/SF (bound and unbound) increased in a dose-dependent manner, whereas soluble c-Met concentrations were generally similar across doses.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; AMG 102 is safe and well tolerated, has a favorable pharmacokinetic profile, and will be further investigated as a monotherapy and in combination with other agents. Clin Cancer Res; 16(2); 699–710&lt;/p&gt;&lt;/div&gt;
Biological markers in breast carcinoma.I. Incidence of abnormalities of CEA, HCG, three polyamines, and three minor nucleosides (1975)

Patients with breast carcinoma were screened for abnormal concentrations of CEA, HCG, putrescine, spermidine, spermine, pseudouridine, N2, N2-dimethylguanosine, and 1-methylinosine. Abnormal polyamine levels occurred in less than 15% of the patients. Among the nucleosides, N2, N2-dimethylguanosine was the most frequently abnormal, occurring in 57% of the patients with metastatic disease. CEA levels were abnormal in 30% of postoperative N+ patients and 74% of patients with metastatic disease, while HCG elevations were found in 45% and 50%, respectively. All the patients with one or more marker abnormalities could be detected by measuring only CEA, N2, N2-dimethylguanosine, and HCG. Among these three tests, a singular marker abnormality occurred in 35.8% of the patients, and all three tests were abnormal in 21.8% of the patients. The performance of these three tests in each patient revealed one or more abnormalities 97% of the patients with metastatic disease, and 67% of the postoperative N+ patients.
High-Speed 1.3-$\mu\hbox{m}$ p-i-n GaNAsSb/GaAs Waveguide Photodetector (2010)

The authors report the demonstration of high-speed GaNAsSb/GaAs p-i -n waveguide photodetector grown by molecular beam epitaxy technique. A 0.4- m-thick GaNAsSb core layer with 3.3% of N and 8% of Sb for detection wavelength over 1.3 m is sandwiched by GaAs and AlGaAs cladding layers. The device exhibits a record value of cutoff frequency of 16.5 GHz.
Radiotherapy or Autologous Stem-Cell Transplantation for Primary CNS Lymphoma in Patients Age 60 Years and Younger: Long-Term Results of the Randomized Phase II PRECIS Study (2022)

<i>Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in</i> JCO <i>or elsewhere, for which the primary end point has already been reported.</i>We previously reported the results of a randomized phase II study in patients with newly diagnosed primary CNS lymphoma (age 18-60 years). Patients were treated with high-dose methotrexate-based induction chemotherapy followed by whole-brain radiotherapy (WBRT) or high-dose chemotherapy (thiotepa-busulfan-cyclophosphamide) with autologous stem-cell transplantation (ASCT). The median follow-up was 33 months. In this report, we provide long-term data (median follow-up, 8 years) regarding the outcomes and toxicities. Fifty-three and 44 patients received induction chemotherapy followed by WBRT or ASCT, respectively. Their 8-year event-free survival from random assignment was 67% and 39% in the ASCT and WBRT arms, respectively (<i>P</i> = .03), with a significantly lower risk of relapse after ASCT (hazard ratio, 0.13; <i>P</i> < .001). One third of patients who relapsed after WBRT were alive after salvage treatment. Five and four patients died of ASCT and WBRT-related toxicities, respectively. The 8-year overall survival was 69% and 65% in the ASCT and WBRT arms, respectively (not significant). Balance (52% <i>v</i> 10%, <i>P</i> ≤ 0.001) and neurocognition (64% <i>v</i> 13%, <i>P</i> < .001) significantly deteriorated after WBRT compared with ASCT during the follow-up. This study shows that 40 Gy WBRT should be avoided in first-line treatment because of its neurotoxicity and suboptimal efficacy in reducing relapses while ASCT appears to be highly efficient in preventing relapses.
Pore Collapse in Weakly Cemented and Porous Rocks (1994)

Withdrawal of fluids from hydrocarbon reservoirs results in a decrease in pore pressure which in turn leads to an increase in effective stress on rock matrix. Such a situation may lead to the occurrence of pore collapse in reservoirs having weakly cemented, porous rocks. It is considered to be a potential problem in several producing reservoirs. Numerical simulation of a compacting reservoir due to pore collapse requires an appropriate constitutive model. Consequently, a constitutive model based on the concept of elasto-plasticity using isotropic hardening is developed to predict pre and post-pore collapse behavior of reservoir rocks. An experimental study is carried out on a high-porosity rock susceptible to pore collapse for different stress paths. The developed constitutive model is tested with respect to two different materials exhibiting such behavior. Parameters for the model are evaluated based on the experimental results, highlighting the procedure involved. Further, the data is used to demonstrate the strengths and the weaknesses of the constitutive model. Experimental data for the second material is obtained from literature. Satisfactory agreement is achieved between experimental data and model predictions.
Neuraxial drug delivery in pain management: An overview of past, present, and future (2023)

Activation of neuraxial nociceptive linkages leads to a high level of encoding of the message that is transmitted to the brain and that can initiate a pain state with its attendant emotive covariates. As we review here, the encoding of this message is subject to a profound regulation by pharmacological targeting of dorsal root ganglion and dorsal horn systems. Though first shown with the robust and selective modulation by spinal opiates, subsequent work has revealed the pharmacological and biological complexity of these neuraxial systems and points to several regulatory targets. Novel therapeutic delivery platforms, such as viral transfection, antisense and targeted neurotoxins, point to disease-modifying approaches that can selectively address the acute and chronic pain phenotype. Further developments are called for in delivery devices to enhance local distribution and to minimize concentration gradients, as frequently occurs with the poorly mixed intrathecal space. The field has advanced remarkably since the mid-1970s, but these advances must always address the issues of safety and tolerability of neuraxial therapy.