gebhart/patrepeval huggingface dataset:
Antenna Link Transfer Function Factorization Applied to Optimized Channel Design (2006)

A channel broadband factored model is developed and numerically verified with a method of moment (MoM) technique for design of optimized UWB links with real, dispersive antennas. In this study, two-antenna link transfer functions are decomposed into port-load and full-wave dependent components based on general linearity and reciprocity in electromagnetics. Specifically, the port-related components account for antenna termination to the transmitter generator and front-end receiver circuits as antenna loads. In turn, the wave portion, which is associated with link transmission impedance, involves all geometrical factors like antenna shapes and their positioning/pointing in space that account collectively for radiation, propagation and reception. As a result, any link of fixed geometry can be full-wave numerically simulated just once for a suitable set of reference generator/load impedances. Then, all variations in link performance caused by variable port terminations are easily predicted by manipulating the full-wave data obtained for the case of reference antenna port loads. This approach provides some useful physical insights and an optimized co-design procedure for transmitter and receiver impedances to meet several significant performance-related design objectives, such as: i) maximized link energy transmission efficiency; ii) maximum amplitude of received signals; iii) minimized time confinement for signal energy at receiver loads; iv) flatness of magnitude of link transfer functions; and v) minimized group delay deviation. The major results are numerically illustrated for a number of useful far-field line-of-sight link cases with flat and solid dipole antennas operating in up to 3:1 bands and ideally aligned in terms of their gain and polarization matching. Numerical results are given in a normalized form and scalable to any band of interest
Stability of fatty acids in hyperlipoproteinemic plasma during long-term storage. (1976)

Aliquots of hyperlipoproteinemic plasma were stored at -20 degrees C in a nitrogen atmosphere with added disodium ethylenediaminetetraacetate for up to one year, to determine the stability of fatty acids in the four major lipid classes under these conditions. Assays were performed at zero time and at 2, 5, and 12 months. No uniform fatty acid change was found. Minor statistically significant changes were found in total triglyceride fatty acids and in some of the individual fatty acids in cholesterol esters, phospholipid, and free fatty acids. These minor changes could not be accounted for by plasma lipid concentrations, lipolysis, or fatty acid peroxidation. Evidently, plasma can be stored in this manner for as long as a year without substantial change in fatty acids in any of the four major lipid classes.
ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice (2013)

KLF3 is a Krüppel family zinc finger transcription factor with widespread tissue expression and no previously known role in heart development. In a screen for dominant mutations affecting cardiovascular function in N-ethyl-N-nitrosourea (ENU) mutagenized mice, we identified a missense mutation in the Klf3 gene that caused aortic valvular stenosis and partially penetrant perinatal lethality in heterozygotes. All homozygotes died as embryos. In the first of three zinc fingers, a point mutation changed a highly conserved histidine at amino acid 275 to arginine (Klf3(H275R) ). This change impaired binding of the mutant protein to KLF3's canonical DNA binding sequence. Heterozygous Klf3(H275R) mutants that died as neonates had marked biventricular cardiac hypertrophy with diminished cardiac chambers. Adult survivors exhibited hypotension, cardiac hypertrophy with enlarged cardiac chambers, and aortic valvular stenosis. A dominant negative effect on protein function was inferred by the similarity in phenotype between heterozygous Klf3(H275R) mutants and homozygous Klf3 null mice. However, the existence of divergent traits suggested the involvement of additional interactions. We conclude that KLF3 plays diverse and important roles in cardiovascular development and function in mice, and that amino acid 275 is critical for normal KLF3 protein function. Future exploration of the KLF3 pathway provides a new avenue for investigating causative factors contributing to cardiovascular disorders in humans.
Focus-Induced Photoresponse: a novel optoelectronic distance measurement technique (2017)

We present the Focus-Induced Photoresponse (FIP) technique, a novel approach to optical distance measurement. It takes advantage of a widely-observed phenomenon in photodetector devices: a nonlinear, irradiance-dependent photoresponse. This means that the output from a sensor is dependent on the total number of photons incident and the size of the area in which they fall. With a certain arrangement of sensor and lens, this phenomenon will cause the output of the sensor to change based on how far in or out of focus an object is. We call this the FIP effect. Here we demonstrate how to use the FIP effect for distance measurements. We show that this technique works with different sensor materials, device types, as well as visible and near infrared light. In principle, any sensor exhibiting a photoresponse that depends nonlinearly on irradiance could be used with the FIP technique. It is our belief that the FIP technique can become an important method for measuring distance.
A comparison of the effectiveness between amniotic membrane homogenate and transplanted amniotic membrane in healing corneal damage in a rabbit model (2011)

Amnion homogenate is as effective as transplanted amniotic membrane in promoting corneal healing in a rabbit model.
A synthetic retinoid antagonist inhibits the human immunodeficiency virus type 1 promoter. (1994)

Retinoids regulate a broad range of biological processes and affect cell growth and differentiation of many cell types, including the immune system. Recently, it was reported that human immunodeficiency virus type 1 (HIV-1) expression in macrophages is enhanced by retinoic acid (RA). Retinoid signals are mediated by the RA receptors (RARs) and retinoid X receptors (RXRs) that bind to specific RA responsive elements (RAREs) in the promoter region of susceptible genes. Here, we report on a RARE in the long terminal repeat (LTR) region that allows activation of the HIV-1 LTR. The RARE is composed of two consensus RARE half-sites (A/GGGTCA) arranged as a palindrome separated by 9 nucleotides and is activated by both RAR/RXR heterodimers and RXR homodimers. We show that the COUP (chicken ovalbumin upstream promoter) orphan receptors also bind to the HIV-1 RARE and repress the retinoid response of the HIV-1 RARE or the HIV-1 LTR. Furthermore, a newly discovered synthetic retinoid is shown to be a potent inhibitor of retinoid-induced activation of the HIV-1 RARE. These observations suggest additional approaches for the inhibition of HIV replication.
Novel sex pheromone desaturases in the genomes of corn borers generated through gene duplication and retroposon fusion (2007)

The biosynthesis of female moth sex pheromone blends is controlled by a number of different enzymes, many of which are encoded by members of multigene families. One such multigene family, the acyl-CoA desaturases, is composed of certain genes that function as key players in moth sex pheromone biosynthesis. Although much is known regarding the function of some of these genes, very little is known regarding how novel genes have evolved within this family and how this might impact the establishment of new sex pheromone blends within a species. We have discovered that several cryptic Delta11 and Delta14 desaturase genes exist in the genomes of the European and Asian corn borers (Ostrinia nubilalis and Ostrinia furnacalis, respectively). Furthermore, an entirely novel class of desaturase gene has arisen in the Ostrinia lineage and is derived from duplication of the Delta11 desaturase gene and subsequent fusion with a retroposon. Interestingly, the genes have been maintained over relatively long evolutionary time periods in corn borer genomes, and they have not been recognizably pseudogenized, suggesting that they maintain functional integrity. The existence of cryptic desaturase genes in moth genomes indicates that the evolution of moth sex pheromone desaturases in general is much more complex than previously recognized.
Intelligent Knowledge Modeling and Distributed Database Constructing for Intelligent Radar Countermeasure (2021)

Intelligent radar countermeasure are the current development trend in the field of radar countermeasure. Knowledge modeling can support the whole process of radar countermeasure. It can not only provide prior knowledge for the countermeasure system but also dynamically update the generated new knowledge. To deal with the rapidly growing mass of knowledge in the knowledge base system, the use of a distributed architecture can ensure the stability of the knowledge base. At present, there are two difficulties in the construction of a knowledge base system in radar countermeasure. First, it is difficult to construct a comprehensive representation for multiple data sources and complex counter-targets. Second, the massive data and knowledge gives huge pressure for storage. To deal with the above problems, we systematically design a hierarchical dynamic knowledge base as well as several sub-databases based on the specific application of intelligent radar countermeasure. Furthermore, the distributed database based on the architecture of Mycat is constructed, which relieves the pressure on storage, reading and writing, as well as the crash risk of a single machine. We have demonstrated the performance of the distributed knowledge base.
Cooperative hybrid-ARQ protocol with network coding (2009)

A novel cooperative Hybrid-ARQ protocol was presented on the basis of network coding (C-HARQ-NC). Two users communicated with the base station with the assistance of a relay node. Relay node responded the repeat request and processed two users' incremental redundancy frames with physical-layer network coding, i.e. signal superposition modulation, before transmitting to the base station. Multi-user joint detection and joint soft decision decoding were adopted at the base station. Compared with traditional Hybrid-ARQ protocol, the C-HARQ-NC protocol can achieve better performance on flat Rayleigh fading channel, and approximates the performance of cooperative Hybrid-ARQ protocol without network coding with fewer hardware and bandwidth resources.
Diamond: a material for acoustic devices (2008)

Abstract Diamond has been foreseen to replace silicon for high power, high frequency electronic applications or for devices that operates in harsh environments. However, diamond electronic devices are still in the laboratory stage due to the lack of large substrates and the complexity of diamond doping. On another hand, surface acoustic wave filters based on diamond are commercially available. Diamond is especially suited for acoustic applications because of its exceptional mechanical properties. The other properties of diamond such as bio‐inertness and chemical stability certainly make of diamond a key material for the next generation of acoustic sensors. In this article, we try to detail the interest of diamond films in composite acoustic applications and review the different type of acoustic devices/sensors. (© 2008 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Abstract 4972: High-throughput functional profiling of dedifferentiated liposarcoma cell lines (2011)

Abstract We previously profiled several adult soft-tissue sarcoma subtypes using sequencing, copy number analysis, and gene expression arrays. This high-throughput genetic profiling revealed dozens of candidate genes deserving of further functional validation. To prioritize genes, we performed a pooled shRNA screen to identify essential genes in liposarcoma. Dedifferentiated liposarcoma (DDLS) served as a model for this approach as multiple robust cell lines are available. Five DDLS cell lines (DDLS8817, LPS141, FU-DDLS-1, RDD8107, and LP6) were infected with a pool of 54,020 lentiviral shRNAs targeting ∼11,000 genes (median 5 shRNAs per gene) and passaged for 16 doublings. DNA was extracted and hairpin sequences were PCR amplified and hybridized to a custom microarray that interrogates all shRNAs in the pool. shRNAs were ranked according to their differential abundance between early and late passages. Genes corresponding to the most significantly depleted shRNAs are presumed to affect cell proliferation and are candidate oncogenes. We compared the pattern of hairpin depletion in the DDLS cell lines to a panel of over 60 cell lines representing other common cancers screened with the same pooled shRNA library. The 5 DDLS cell lines clustered into 3 distinct groups. Only one gene appeared to be essential in all 3 groups: WWTR1 (TAZ1), a master-regulator of adipocyte differentiation. Twenty-eight genes appeared essential in at least two DDLS groups including MDM2 and ZBTB2, both reported to negatively regulate the tumor suppressor gene TP53. Low-throughput in vitro experiments have confirmed that WWTR1 knockdown using two shRNA clones inhibits LPS141 proliferation by 78 and 75% after 4 days as compared to scramble (p=0.004 and 0.06 respectively). Our complementary genome-scaled functional screen has confirmed a known oncogene in DDLS and revealed additional candidate genes that appear to have a role in proliferation. Further integration of existing datasets may nominate additional genes essential for liposarcoma pathogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4972. doi:10.1158/1538-7445.AM2011-4972
Organic Cation Transporter Variation and Response to Smoking Cessation Therapies (2014)

The functional OCT2 Ser270Ala polymorphism is nominally statistically significantly associated with abstinence among European-ancestry treatment-seeking smokers after adjustments for pharmacotherapy, demographics, population genetics, and without adjustment for multiple testing of 7 SNPs. Replication of these preliminary findings in additional randomized controlled trials of smoking cessation therapies and from multiple continental populations would describe another pharmacogenetic role for SLC22A2/OCT2.
Studies on Seven-membered Ring Compounds. XXII. Preparation of Tropylium Ions Having Fused Heterocyclic Systems (1967)

The preparation of tropylium ions having a fused oxazole, imidazole or thiazole nucleus is described. The heating of 2-benzoylaminotropone (I) and dimethyl sulfate produced 2-phenyloxazolotropylium ion (IIIa). The disproportionation reaction of IIIa with aqueous alkali gave 2-phenyl-6H-cycloheptoxazole (V) and 2-phenyl-6H-cycloheptoxazol-6-one (IV), The structures of which were proved by the reactions shown in Chart 1 and by examination of the spectra. 2-Phenylthiazolotropylium ion (XVIIb) and 1-p-tolyl-2-phenylimidazolotropylium ion (XXI) were prepared, respectively, by the simple dissolution of 2-benzoylaminotroponthion (XVI) and 2-benzoylamino-N-p-tolyltroponeimine (XX) in dilute hydrochloric acid. Treatment of both ions XVIIb and XXI with aqueous alkali resulted in the disproportionation reaction in which the former gave XVIII and XIX and the latter XXII and XXIII. The NMR spectra of the ions, XVII and XXI, showed the significant contribution of the tropylium ion structure of these compounds.
Abstract 921: TLR5 agonists enhance anti-tumor immunity and overcome resistance to immune checkpoint therapy (2020)

Abstract Despite the success of immune checkpoint therapies (ICT) in achieving durable responses in subsets of cancer patients, not all patients respond to these types of therapies. Primary and adaptive resistance to immunotherapies present a considerable obstacle in achieving enhanced survival in a broader population of patients. Innate immune activators have been actively pursued for their antitumor potential. Herein, we report that a syngeneic 4T1 mammary carcinoma murine model for established highly refractory triple negative breast cancer showed enhanced survival when treated intra-tumorally with the TLR5 agonist flagellin, in combination with intra-peritoneal antibodies targeting CTLA-4 and PD-1. Long-term survivor mice showed immunologic memory upon tumor re-challenge and a distinctive immune activating cytokine profile that engaged both innate and adaptive components of the immune system. Of note, low serum levels of G-CSF at weeks 6 and 7 correlated highly with enhanced survival at week 18 (Hazzard Ratio 11, p &amp;lt; 0.01, n=11). Furthermore, we also observed enhanced survival with combination TLR5 agonist plus ICT in the poorly immunogenic B16-F10 melanoma tumor model. Combination immune checkpoint therapy plus innate immune activation with TLR5 agonists may offer a new therapeutic strategy to treat ICT-refractory solid tumors. Citation Format: Caleb Gonzalez, Sarah Williamson, Seth Gammon, David Piwnica-Worms. TLR5 agonists enhance anti-tumor immunity and overcome resistance to immune checkpoint therapy [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 921.
Real-Time Digital Signatures for Time-Critical Networks (2017)

The secure and efficient operation of time-critical networks, such as vehicular networks, smart-grid, and other smart-infrastructures, is of primary importance in today's society. It is crucial to minimize the impact of security mechanisms over such networks so that the safe and reliable operations of time-critical systems are not being interfered. For instance, if the delay introduced by the crypto operations negatively affects the time available for braking a car before a collision, the car may not be able to safely stop in time. In particular, as a primary authentication mechanism, existing digital signatures introduce a significant computation and communication overhead, and therefore are unable to fully meet the real-time processing requirements of such time-critical networks. In this paper, we introduce a new suite of real-time digital signatures referred to as Structure-free and Compact Real-time Authentication (SCRA), supported by hardware acceleration, to provide delay-aware authentication in time-critical networks. SCRA is a novel signature framework that can transform any secure aggregate signature into a signer efficient signature. We instantiate SCRA framework with condensed-RSA, BGLS, and NTRU signatures. Our analytical and experimental evaluation validates the significant performance advantages of SCRA schemes over their base signatures and the state-of-the-art schemes. Moreover, we push the performance of SCRA schemes to the edge via highly optimized implementations on vehicular capable system-on-chip as well as server-grade general purpose graphics processing units. We prove that SCRA is secure (in random oracle model) and show that SCRA can offer an ideal alternative for authentication in time-critical applications.
A Bayesian Algorithm for Distributed Network Localization Using Distance and Direction Data (2018)

A reliable, accurate, and affordable positioning service is highly required in wireless networks. High-resolution estimates of distance and direction data are available in most current and emerging wireless systems. Combining these two sensing modalities can improve the estimation performance and identifiability of the cooperative localization problem, and reduce its sensitivity to the geometry of anchor nodes, i.e., the reference nodes with known locations. However, this is still an open and challenging research problem. In this paper, the novel Message Passing Hybrid Localization (MPHL) algorithm is proposed to solve the problem of cooperative distributed localization using joint distance and direction estimates without any prior information. A statistical model is formulated for the problem, and approximate minimum mean square error (MMSE) estimates of the node locations are computed. The proposed MPHL algorithm is a distributed technique based on belief propagation and Markov chain Monte Carlo sampling. Numerical results are presented showing that the average localization error is significantly reduced in almost every simulation scenario, about 50% in most cases, compared to the state of the art. This improvement in localization performance is due to close approximation of a statistically optimal MMSE estimator.
MONOAMINES AS POSSIBLE MEDIATORS IN THE REGULATION OF FAST AXOPLASMIC FLOW (1976)

Abstract —The effect of drugs which have been shown to alter monoamines in the CNS on the rate of fast axoplasmic flow of [ 3 H]leucine labelled material in the rat sciatic nerve was examined. Drugs which deplete monoamines led to a decrease while those which increase the level of monoamines led to an increase in the rate of fast axoplasmic flow. Monoaminergic drugs were also found to alter the amount of [ 3 H]leucine incorporated into spinal cord.
The illumination angle dependency of CPV solar cell electrical performance (2017)

CPV systems aim to deliver electrical power at lower cost than will be possible with traditional photovoltaics. To achieve this, maximum performance from the solar cells should be obtained, while minimizing the cost of balance-of-system. Therefore it is important that CPV optical systems are evaluated in terms of their impact on solar cell performance. One attribute of particularly lens based CPV systems is the variance in incidence angles of light at the solar cell surface, especially when a secondary optic element is employed. The electrical performance of TJ CPV solar cells for varying angles of incident illumination is studied in detail. The solar cells suffer a loss of performance of up to 58% for oblique illumination. Calculations and ray tracing simulations show that optical losses are caused by Fresnel reflections off the ARC, and scattered reflections off the front metal grid due to surface roughness. Additionally the merit of using secondary optics in spite of this effect is shown for symmetrical CPV systems. For asymmetrical (i.e. prism based) systems however, the loss of performance may be substantially larger. Therefore grid orientation and design in respect to the optical system should be taken into account and optimized in such systems.
Phosphatases: Counterregulatory role in inflammatory cell signaling (2002)

Cellular responses to external stimuli proceed through multiply complex signal transduction networks. The manner by which signals are propagated from the cell's surface to the nuclei is, in large part, dependent on the phosphorylation of signaling proteins mediated by kinases. As in most biological systems, this process of kinase-mediated phosphorylation is balanced by the presence of a dephosphorylating system comprised of a number of families of phosphatases. The purpose of this review is to describe the various members of the main classes of phosphatases and to examine their role in regulating signal transduction pathways relevant to critical illness. Because recent work has provided key insight into the role of kinase-mediated signaling pathways, such as the mitogen-activated protein kinase and inhibitor of nuclear factor-kappaB kinase pathways, in inflammatory states, emphasis has been placed on the regulation of these events. It is hoped that deriving novel insight into the regulatory phosphatases will allow a greater understanding of inflammatory cell signaling events and potentially identify novel sites for therapeutic intervention in the future.