gebhart/patrepeval huggingface dataset:
A Continuous Bovine Kidney Cell Line Constitutively Expressing Bovine αVβ6Integrin Has Increased Susceptibility to Foot-and-Mouth Disease Virus (2013)

Foot-and-mouth disease (FMD) is a worldwide problem limiting the trade of animals and their products from affected countries. The rapid isolation, serotyping, and vaccine matching of FMD virus from disease outbreaks is critical for enabling the implementation of effective vaccination programs and to stop the spread of infection during outbreaks. Some primary cells have been shown to be highly susceptible to most strains of FMD virus (FMDV) but are difficult and expensive to prepare and maintain. Since the αVβ6 integrin is a principal receptor for FMDV, we transduced a bovine kidney cell line to stably express both the αV and β6 bovine integrin subunits. This stable cell line (LFBK-αVβ6) showed β6 expression and enhanced susceptibility to FMDV infection for ≥ 100 cell passages. LFBK-αVβ6 cells were highly sensitive for detecting all serotypes of FMDV from experimentally infected animals, including the porcinophilic FMDV strain O/TAW/97. In comparison to other cell types that are currently used for virus isolation, LFBK-αVβ6 cells were more effective at detecting FMDV in clinical samples, supporting their use as a more sensitive tool for virus isolation.
Evaluation Of Rssi-Based Human Tracking (2015)

Publication in the conference proceedings of EUSIPCO, Tampere, Finland, 2000
Author response: Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels (2017)

Pro-nociceptive and pro-inflammatory TRPM3 (transient receptor potential melastatin 3) channels, expressed in somatosensory neurons, are inhibited by activation of Gαi-coupled receptors, such as µ-opioid receptors, in vitro and in vivo.
Effect of controlled volumetric tissue heating with radiofrequency on cellulite and the subcutaneous tissue of the buttocks and thighs. (2006)

Based on the demonstrated results with real-time ultrasound scanning, we have observed that 2 RF treatments on the subcutaneous tissue of the buttocks and thighs provide a volumetric contraction effect in the majority of patients. This validates the primary hypothesis of our protocol and establishes that the RF energy works on the connective tissue of the subcutaneous adipose tissue. This effect should be the same on any other body part.
Regulatory Roles of the N-Terminal Domain Based on Crystal Structures of Human Pyruvate Dehydrogenase Kinase 2 Containing Physiological and Synthetic Ligands , (2005)

Pyruvate dehydrogenase kinase (PDHK) regulates the activity of the pyruvate dehydrogenase multienzyme complex. PDHK inhibition provides a route for therapeutic intervention in diabetes and cardiovascular disorders. We report crystal structures of human PDHK isozyme 2 complexed with physiological and synthetic ligands. Several of the PDHK2 structures disclosed have C-terminal cross arms that span a large trough region between the N-terminal regulatory (R) domains of the PDHK2 dimers. The structures containing bound ATP and ADP demonstrate variation in the conformation of the active site lid, residues 316-321, which enclose the nucleotide beta and gamma phosphates at the active site in the C-terminal catalytic domain. We have identified three novel ligand binding sites located in the R domain of PDHK2. Dichloroacetate (DCA) binds at the pyruvate binding site in the center of the R domain, which together with ADP, induces significant changes at the active site. Nov3r and AZ12 inhibitors bind at the lipoamide binding site that is located at one end of the R domain. Pfz3 (an allosteric inhibitor) binds in an extended site at the other end of the R domain. We conclude that the N-terminal domain of PDHK has a key regulatory function and propose that the different inhibitor classes act by discrete mechanisms. The structures we describe provide insights that can be used for structure-based design of PDHK inhibitors.
Advances in cryo-vacuum test capabilities for dual-band sensors at the kinetic kill vehicle hardware-in-the-loop simulation (KHILS) facility (2004)

The KHILS Vacuum Cold Chamber (KVACC) has formed the basis for a comprehensive test capability for newly developed dual-band infrared sensors. Since initial delivery in 1995, the KVACC chamber and its support systems have undergone a number of upgrades, maturing into a valuable test asset and technology demonstrator for missile defense systems. Many leading edge test technologies have been consolidated during the past several years, demonstrating the level of fidelity achievable in tomorrow's missile test facilities. These technologies include resistive array scene projectors, sub-pixel non-linear spatial calibration and coupled two-dimensional radiometric calibration techniques, re-configurable FPGA based calibration electronics, dual-band beam-combination and collimation optics, a closed-cycle multi-chamber cryo-vacuum environment, personal computer (PC) based scene generation systems and a surrounding class-1000 clean room environment. The purpose of this paper is to describe this unique combination of technologies and the capability it represents to the hardware-in-the-loop community.
Assessment of Suicidal Ideation and Behavior (2017)

All 5 working groups agreed that a major barrier to advancement of the field of SI/SB research and the development of new treatments for SI/SB remains the lack of a universally accepted standardized nomenclature and classification system. Achieving alignment on definitions and classification of suicide-related phenomena is critical to improving the detection and assessment of SI/SB, the design of clinical trials for new treatments, and effective public health interventions.
Total recall: a debugging framework for GPUs (2008)

GPUs have transformed from simple fixed-function processors to powerful, programmable stream processors and are continuing to evolve. Programming these massively parallel GPUs, however, is very different from programming a sequential CPU. Lack of native support for debugging coupled with the parallelism in the GPU makes program development for the GPU a non-trivial task. As GPU programs grow in complexity because of scaling in maximum allowed program size and increased demand in terms of realism, debugging GPU code is becoming a major timesink for content developers. In addition to more complex shaders, applications are using multi-pass effects in order to create more convincing reality. In this paper, we present a debugging framework that can be employed to debug complex code running on the GPU in an efficient manner. By observing the API calls of the application that are made to the 3D runtime, the framework can keep track of the program's state in memory. Upon the programmer's request, it is able to capture and deterministically replay the stream of instructions that caused the final write to a pixel of interest. This execution stream includes writes to intermediate render targets and spans across shader boundaries. The stream of instructions can then be replayed on the CPU via emulation and the programmer can debug the straight-line code with ease. We also present a hardware-friendly scheme that can be used to accelerate the debugging process for long-chain multi-pass effects.
Interaction of vitamins and minerals. (1991)

Several nutrients are known to act on the metabolism of other nutrients and also of some non-nutrient substances. The nutritional importance that may be attributed to these interrelationships depends on the levels considered to be physiological for each nutrient, and on their maintenance at acceptable levels in tissues for the defense of the organism. Interaction of vitamins and minerals has been described in several metabolic situations and continues to be investigated by many authors. This interaction occurs in different ways, i.e. starting from the action of vitamins on mineral metabolism, from the action of both types of nutrients in the protection of the organism, and from the action of minerals on vitamin metabolism. The most significant example of vitamin action on mineral metabolism is the role played by vitamin D in calcium and phosphorus metabolism. The interrelationship of vitamin C and some minerals is also discussed, with emphasis on its relationship with iron. With respect to the synergistic action of vitamins and minerals in the defense of the organism, we comment on the main data reported on the biochemical-physiological role of vitamin E and its interaction with selenium. Finally, in reference to the action of minerals on vitamin metabolism, we point out the interaction existing between vitamin A and zinc. Data observed by the author at the experimental level in laboratory animals are reported on the possible interaction of niacin, vitamin B6 and zinc.
Uptake of Cystine by the Yeast Phase of Histoplasma capsulatum (1970)

This report deals with factors affecting the uptake of cystine by the yeast phase of Histoplasma capsulatum. The kinetics of uptake showed a saturation at 70 muM and an average K(m) value of 3 x 10(-5)m. The optimal pH and temperature for transport of cystine were 6.5 and 37 C, respectively. The energy of activation was 14.1 kcal/mole, and the temperature coefficient value was 2.1. A requirement for energy supplied by metabolic activity was demonstrated by the inhibition of incorporation of the amino acid by cells preincubated with either 2,4-dinitrophenol or sodium azide. Although uptake was not inhibited by any single amino acid, a combination of amino acids did cause a decrease in uptake. Thus, the data show that the uptake of cystine by yeast cells of H. capsulatum has the characteristics of a system of transport that requires the expenditure of energy by the cells.
Mode Filters for Oversized Rectangular Waveguides (1968)

In order to suppress trapped-mode resonances and other disturbing phenomena related to the existence of higher-order modes in oversized waveguides, suitable mode filters are required. In this paper such filters are described for rectangular waveguides in which only the dominant H/sub 10/ mode is wanted. The unwanted modes to be suppressed by the mode filters are classified as 1) E/sub mn/ and H/sub mn/ modes with n /spl ne/ 0, and 2) H/sub m0/ modes with m /spl ne/ 1. These two types of modes must be treated separately and require different approaches to the mode-filtering problem. For both classes several constructions of mode filters are described and analyzed.
The distribution of phosphorylation sites among identified proteolytic fragments of mammalian neurofilaments. (1983)

Neurofilaments were treated with chymotrypsin or with Staphylococcus aureus V8 protease (V8 protease) and the proteolytic fragments in soluble and particulate centrifugal fractions were identified by immune blotting, using antibodies raised against the Mr = 68,000 (P68), 145,000 (P145), and 200,000 (P200) subunits. The data provide further evidence that each of the three subunits has a different disposition within the filament. A Mr = 160,000 fragment of P200, which may correspond to the side arm projections on neurofilaments, was released into solution by chymotrypsin. In contrast, the proteolytic fragments of P68 and P145 were recovered mainly in the particulate centrifugal fraction, indicating that the two subunits are more closely associated with the filament backbone. Proteolytic cleavage studies on neurofilaments that were 32P-labeled in vivo indicated that the phosphorylated domains in P200 and P145 are localized in a restricted segment of each subunit, which occurs between the chymotryptic and V8 protease cleavage sites. No 32P was associated with the bulk of chymotryptic fragments, which are found in the particulate fraction, are about 40,000 daltons in size, and derive from all three neurofilament subunits. Most of the phosphorylation sites in neurofilaments are peripherally located in the projection domain of P200, suggesting that phosphorylation may modulate interactions between neurofilaments and other neuronal components.
Transplantation of Enteric Cells into the Rodent Stomach with Basic Fibroblast Growth Factor (2011)

Enteric cells, isolated from intestinal smooth muscle strips, were transplanted into the syngeneic rodent stomach in collagen gel with and without basic fibroblast growth factor (bFGF). While growth factor delivery did not affect cell viability after transplantation, bFGF promoted the formation of numerous ganglion-like structures at the injection site and adjacent muscularis. Immunohistochemistry staining revealed the presence of peripherin, S100, and synaptophysin in these ganglion-like structures. A small percentage of transplanted enteric cells expressed peripherin in the injection site after transplantation. Enteric cells transplanted with collagen and bFGF may hold potential as a cellular therapeutic for various motility disorders of the gastrointestinal tract.
LDLR Database (second edition): new additions to the database and the software, and results of the first molecular analysis (1998)

Mutations in the LDL receptor gene (LDLR) cause familial hypercholesterolemia (FH), a common autosomal dominant disorder. The LDLR database is a computerized tool that has been developed to provide tools to analyse the numerous mutations that have been identified in the LDLR gene. The second version of the LDLR database contains 140 new entries and the software has been modified to accommodate four new routines. The analysis of the updated data (350 mutations) gives the following informations: (i) 63% of the mutations are missense, and only 20% occur in CpG dinucleotides; (ii) although the mutations are widely distributed throughout the gene, there is an excess of mutations in exons 4 and 9, and a deficit in exons 13 and 15; (iii) the analysis of the distribution of mutations located within the ligand-binding domain shows that 74% of the mutations in this domain affect a conserved amino-acid, and that they are mostly confined in the C-terminal region of the repeats. Conversely, the same analysis in the EGF-like domain shows that 64% of the mutations in this domain affect a non-conserved amino-acid, and, that they are mostly confined in the N-terminal half of the repeats. The database is now accessible on the World Wide Web at http://www.umd.necker.fr
Opening of epoxides with trimethylsilyl cyanide to produce .beta.-hydroxy isonitriles. A general synthesis of oxazolines and .beta.-amino alcohols (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOpening of epoxides with trimethylsilyl cyanide to produce .beta.-hydroxy isonitriles. A general synthesis of oxazolines and .beta.-amino alcoholsPaul G. Gassman and Thomas L. GuggenheimCite this: J. Am. Chem. Soc. 1982, 104, 21, 5849–5850Publication Date (Print):October 1, 1982Publication History Published online1 May 2002Published inissue 1 October 1982https://pubs.acs.org/doi/10.1021/ja00385a078https://doi.org/10.1021/ja00385a078research-articleACS PublicationsRequest reuse permissionsArticle Views919Altmetric-Citations81LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PARMON: a portable and scalable monitoring system for clusters (2000)

Workstation/PC clusters have become a cost-effective solution for high performance computing. C-DAC's PARAM 10000 (or OpenFrame, internal code name) is a large cluster of high-performance workstations interconnected through low-latency and high bandwidth networks. The management and control of such a huge system is a tedious and challenging task since workstations/PCs are typically designed to work as a standalone system rather than part of a cluster. We have designed and developed a tool called PARMON that allows effective monitoring and control of large clusters. It supports the monitoring of critical system resource activities and their utilization at three different levels: entire system, node and component level. It also allows the monitoring of multiple instances of the same component; for instance, multiple processors in SMP type cluster nodes. PARMON is a portable, flexible, interactive, scalable, location-transparent, and comprehensive environment based on client–server technology. The major components of PARMON are parmon-server—system resource activities and utilization information provider and parmon-client—a GUI based client responsible for interacting with parmon-server and users for data gathering in real-time and presenting information graphically for visualization. The client is developed as a Java application and the server is developed as a multithreaded server using C and POSIX/Solaris threads since Java does not support interfaces to access system internals. PARMON is regularly used to monitor PARAM 10000 supercomputer, a cluster of 48+ Ultra-4 workstations powered by the Solaris operating system. The recent popularity of Beowulf-class clusters (dedicated Linux clusters) in terms of price–performance ratio has motivated us to port PARMON to Linux (accomplished by porting system dependent portions of parmon-server). This enables management/monitoring of both Solaris and Linux-based clusters (federated clusters) through a single user interface. Copyright © 2000 John Wiley & Sons, Ltd.
X-Press Compactor for 1000x Reduction of Test Data (2006)

The paper presents a two-stage test response compactor with an overdrive section and scan chain selection logic. The proposed solution is capable of handling a wide range of X state profiles, offers compaction much higher than the ratio of scan chains to compactor outputs, and provides excellent diagnostic resolution
Health in environment: reduce surgical site infections by applying Florence nightingale’s environmental theory (2020)

Surgical site infection is one of the most common causes of readmission in hospitals and it also leads to an overall increased burden. This can be decreased by applying basic concepts of Nightingale (1860) "Environmental Theory" while giving care to the patients. Keeping in view Nightingale's environmental theory, this paper aims to discuss the case of a patient suffering from a surgical site infection. It will help readers to understand the environmental factors which affect the patients' health and provide a way to promote healing and fast recovery by modifying their environment.
Supplementary Table 3 from Concordant Effects of Aromatase Inhibitors on Gene Expression in ER<sup>+</sup> Rat and Human Mammary Cancers and Modulation of the Proteins Coded by These Genes (2023)

&lt;p&gt;XLSX file - 426K&lt;/p&gt;
Homo‐ and diblock copolymers of poly(furfuryl glycidyl ether) by living anionic polymerization: Toward reversibly core‐crosslinked micelles (2012)

Abstract We report the synthesis and characterization of well‐defined homo‐ and diblock copolymers containing poly(furfuryl glycidyl ether) (PFGE) via living anionic ring‐opening polymerization using different initiators. The obtained materials were characterized by SEC, MALDI‐TOF MS, and 1 H NMR spectroscopy and molar masses of up to 9400 g/mol were obtained for PFGE homopolymers. If the amphiphilic diblock copolymer PEG‐ block ‐PFGE was dissolved in water, micelles with a PFGE core and a PEG corona were formed. Hereby, the hydrophobic PFGE core domains were used for the incorporation of a suitable bismaleimide and heating to 60 °C induced the crosslinking of the micellar core via Diels‐Alder chemistry. This process was further shown to be reversible. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
A Non-Intrusive Online FPGA Test Scheme Using a Hardwired Network on Chip (2011)

Modern Field Programmable Gate Arrays (FPGAs) posses small features, and have gained popularity in mission-critical systems. However, due to small FPGA features and harsh external conditions that can be faced by a mission-critical system, an FPGA chip can suffer from faults. This in turn raises the need to test an FPGA to ensure a reliable system performance. However, a mission-critical system requires that the test process should be non-intrusive, i.e., applications & FPGA regions that are not being tested remain unaffected. Hence, an online test scheme is required that not only verifies the correctness of an FPGA, but also does not degrade the performance of other, running FPGA applications. In this paper, we propose a Hardwired Network on Chip (HWNoC) as the Test Access Mechanism (TAM). Our online test scheme uses a HWNoC, to perform real-time streaming of test data that is non-intrusive to other communication traffic. Additionally, our online test scheme exhibits approx. 18 and 29 times lower spatial and temporal overheads as compared to existing schemes, respectively.
A Polymorphism in GABRA2 Is Associated With the Medial Frontal Response to Alcohol Cues in an fMRI Study (2010)

These are the first data to suggest that GABRA2 genotype could affect the brain's responses to cues associated with alcohol.
Correction to “Particle dynamics in a hydrodynamic separator subject to transient rainfall‐runoff” (2009)

the last sentence of section 5 contains an error introduced during the production process. The sentence should read as follows.
Can a Humanoid Robot Engage in Heartwarming Interaction Service at a Hotel? (2018)

While more and more robots have been employed in the service industry, the impact of the human--robot social interaction on a heartwarming interaction service mostly remains an open question. For the purpose of exploring the possibility that a humanoid robot engages in a heartwarming interaction service, we developed herein the first prototype of the service system through a humanoid robot and conducted a field study, where a humanoid robot engages in the service for a customer at a hotel to collect a customer's impression of the service by questionnaire. The results demonstrate a humanoid robot's potential of engaging in a heartwarming interaction service that enhances customer satisfaction of the whole service. An exploratory analysis suggests the differences of the impact in sex and long-term interaction. Finally, we discuss the possibility of another application, namely, effective advertisement through a heartwarming interaction with a humanoid robot.