gebhart/patrepeval huggingface dataset:
Supplementary Figure 3 from Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model (2023)

&lt;p&gt;Supplementary Figure 3. Treatment of GL261 glioma-bearing mice with MBZ-NH2 or MBZ-OH&lt;/p&gt;
A Modest Proposal for the Abolition of Custodial Confessions (1989)

More than twenty years ago, the United States Supreme Court held in Miranda v. Arizona that confessions would be per se inadmissible if obtained by police who had failed to inform a criminal suspect of his constitutional rights and the consequences of waiving them.Miranda's rule aimed at dissipating the inherent coerciveness of custodial interrogation.Supreme Court cases subsequent to Miranda, however, gradually have eviscerated the landmark decision.In this Article Professors Irene Merker Rosenberg and Yale L. Rosenberg criticize Miranda as originally fashioned, examine its decline, and propose a new per se rule that deems all custodial statements inadmissible.The authors note that by disingenuously blurring the rule of Miranda, the Supreme Court has made the law difficult to follow and has allowed-perhaps implicitly encouraged-lower courts, prosecutors, and police to ignore the rights of criminal defendants in the same disingenuous manner.
Assay Method Development and Validation for Simultaneous Estimation of Mometasone Furoate and Azelastine HCL for Nasal Spray by RP-HPLC (2019)

<em>A simple, precise, accurate, method was developed and validated for analysis of Mometasone Furoate and Azelastine Hydrochloride in nasal spray formulations. For development, different chromatographic condition and stress conditions like acid, base, peroxide, thermal and humidity as per ICH guidelines were used. Method was developed on reversed-phase C<sub>18</sub> column using a mobile phase consisting of potassium dihydrogen, phosphate buffer and acetonitrile. Other HPLC parameters were flow rare 1 ml/min, detection wavelength 239 nm, injection volume 20 </em><em>µl</em><em> and column temperature 30°C. The developed method was further validated with respect to linearity, precision, accuracy, specificity and robustness. The results obtained were within the acceptance criteria as per ICH guidelines.</em>
Conversion of radiant light energy in photobioreactors (1994)

Abstract The conversion of radiant light energy into chemical affinity by microorganisms in photobioreactors is examined. The kinetics of entropy production in the system is theoretically established from entropy and energy balances for the material and photonic phases in the reactor. A negative chemical affinity term compensated for by a radiant energy term at a higher level of energy characterizes photosynthetic organisms. The local volumetric rate of radiant light energy absorbed, which appears in the dissipation function as an irreversible term, is calculated for monodimensional approximations providing analytical solutions and for general tridimensional equations requiring the solution of a new numerical algorithm. Solutions for the bluegreen alga Spirulina platensis cultivated in photoreactors with different geometries and light energy inputs are compared. Thermodynambic efficiency of the photosynthesis is calculated. The highest value of 15% found for low radiant energy absorption rates corresponds to a maximum quantum yield in the reactor.
Session details: Session 4B: Human-Robot Interaction (2019)

No abstract available.
Opening a Can of Worms (2015)

Opening the capital account is like opening a can of worms for Beijing’s senior leaders, as they would need to implement a whole range of deep-rooted structural reforms that could threaten the stability of the Communist Party. Why does China still want to walk into the Impossible Trinity and “suffer” the consequences? Do the Chinese leaders know what challenges and risks they are facing? One potentially detrimental risk is massive capital flight, which has its structural roots in the corrupted system that China’s senior leaders are aiming to rectify.
Experimental Evaluation of Conditions Affecting Specimen Survivability in Atom Probe Tomography (2015)

Journal Article Experimental Evaluation of Conditions Affecting Specimen Survivability in Atom Probe Tomography Get access TJ Prosa, TJ Prosa CAMECA Instruments, Inc., Madison, WI, USA Search for other works by this author on: Oxford Academic Google Scholar D Lawrence, D Lawrence CAMECA Instruments, Inc., Madison, WI, USA Search for other works by this author on: Oxford Academic Google Scholar D Olson, D Olson CAMECA Instruments, Inc., Madison, WI, USA Search for other works by this author on: Oxford Academic Google Scholar S Strennen, S Strennen CAMECA Instruments, Inc., Madison, WI, USA Search for other works by this author on: Oxford Academic Google Scholar I Martin, I Martin CAMECA Instruments, Inc., Madison, WI, USA Search for other works by this author on: Oxford Academic Google Scholar DJ Larson, DJ Larson CAMECA Instruments, Inc., Madison, WI, USA Search for other works by this author on: Oxford Academic Google Scholar RL Martens, RL Martens Metallurgical and Materials Engineering, University of Alabama, Tuscaloosa, AL, USA Search for other works by this author on: Oxford Academic Google Scholar J Goodwin, J Goodwin Metallurgical and Materials Engineering, University of Alabama, Tuscaloosa, AL, USA Search for other works by this author on: Oxford Academic Google Scholar A Portavoce, A Portavoce Aix-Marseille Universite, IM2NP, F-13397 Marseille Cedex, France Search for other works by this author on: Oxford Academic Google Scholar D Mangelinck D Mangelinck Aix-Marseille Universite, IM2NP, F-13397 Marseille Cedex, France Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 21, Issue S3, 1 August 2015, Pages 849–850, https://doi.org/10.1017/S1431927615005048 Published: 23 September 2015
Excitation Wavelength Dependence of Energy Transfer and Charge Separation in Reaction Centers from Rhodobacter sphaeroides:  Evidence for Adiabatic Electron Transfer (1996)

Femtosecond transient absorption spectroscopy has been used to investigate the excitation wavelength dependence of energy transfer and initial charge separation processes in reaction centers of the purple nonsulfur photosynthetic bacterium Rhodobacter sphaeroides (R-26) at room temperature. The QY transition bands of the bacteriopheophytins (H), bacteriochlorophyll monomers (B), and special pair (P) were selectively excited with pulses of 150 fs duration and 5 nm spectral bandwidth. Absorbance changes were analyzed over the entire wavelength region from 700 to 1000 nm. From this analysis we concluded the following: (1) As seen by others, energy transfer between H, B, and P is extremely fast, occurring on the 100−300 fs time scale. (2) The spectral evolution of the system is excitation wavelength dependent for picoseconds after excitation, implying that vibrational relaxation is not complete on the time scale of either energy transfer or charge separation and suggesting that the pathway of charge separation may be excitation wavelength dependent. (3) The absorbance change spectra of the initial excited states of B and H are not consistent with intensity borrowing between these bands, reopening the question of what gives rise to the complex absorbance changes normally associated with the HA- state. (4) The 10−20 ps component of the stimulated emission decay is excitation wavelength dependent and spectrally different from the dominant 2−3 ps decay of the stimulated emission. This component is unlikely to represent a static conformational heterogeneity in the reaction center charge separation rate. These conclusions lead to the proposal of the following model for energy and electron transfer in the reaction center. Energy transfer in this system is very fast because it is mediated by electron exchange interactions between cofactors (implying relatively strong electronic coupling for electron transfer) and because there is little nuclear displacement between donor and acceptor potential surfaces during energy transfer. Electron transfer is slower than energy transfer because the nuclear displacement is larger, and the rate is limited by movement along the reaction coordinate. Thus, initial electron transfer occurs in the near adiabatic limit before vibrational relaxation is complete. This model would explain many issues which have been difficult to resolve using standard electron transfer models including the difficulty in identifying the P+BA- intermediate and the insensitivity of the initial electron transfer rate to temperature and driving force.
1H NMR Spectroscopic Microanalysis Using Precision Coaxial Tubing and the Limit of Detection. (1992)

高分子中に含まれる末端基や異種結合などの微量成分の同定と定量は高分子の物性や重合反応の理解にとって重要な意味を持つ. NMR用同軸二重試料管を用い, 信号強度の基準となる試料を封じた種々の濃度の基準内管を用意すると, 広範囲の濃度の試料成分の定量を高い精度で行えるので, 微量成分の定量にも有効な手法となる. 本研究では, 同軸二重試料管を用いてNMR用の重水素化溶媒中の残存水素, 水, 微量不純物の定量分析, ならびに, 二重試料管法を用いたNMR分析の定量限界について検討した. 定量限界は, 100MHz 1H NMRで成分量にして1.5ppm, 500MHz 1H NMRでは0.05ppmであり, その分析精度及び正確度は±10%以内であった. 市販の11種類の重水素化溶媒中の残存水素量は0.033～0.929w/v%ですべて保証値以内であった. H2Oの量は0.003～0.045w/v%とかなりばらつきがあり, その他の微量の不純物は総量で水素含有量として15.99～1742×10-5gH/lであった. これらの重水素化溶媒の中には故意に重水を混入させたもののあることがわかった. 例えば, 重アセトンの 1H NMRにはH2OとHDO, 2H NMRにはHDOとD2Oによるシグナルが観測された. さらに, ポリマーの強い吸収とともに存在する微量成分の定量性を調べてNMR装置のダイナミックレンジについて検討し, 末端基定量による分子量測定の精度についても調べた.
Supplementary Methods & Figures S1-S5 from Tracing Founder Mutations in Circulating and Tissue-Resident Follicular Lymphoma Precursors (2023)

&lt;p&gt;Supplementary Methods and Figures S1-S5&lt;/p&gt;
Surface plasmon resonance sensor based on U-shaped photonic quasi-crystal fiber (2021)

A high-sensitivity surface plasmon resonance (SPR) sensor is designed and analyzed numerically. The sensor is constructed on the eightfold U-shaped photonic quasi-crystal fiber (PQF) and coated with indium tin oxide (ITO). The coupling between the core mode and surface plasmon polariton mode is enhanced due to shortening of the distance between the core and the ITO layer, so that the PQF-SPR sensor exhibits high refractive index (RI) sensitivity in the near-infrared region. The maximum wavelength sensitivity and the corresponding resolution of this sensor are 42,000 nm/RIU and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mn>2.38</mml:mn> </mml:mrow> <mml:mo>×</mml:mo> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msup> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mn>10</mml:mn> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mo>−</mml:mo> <mml:mn>6</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> <mml:mspace width="thickmathspace"/> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi mathvariant="normal">R</mml:mi> <mml:mi mathvariant="normal">I</mml:mi> <mml:mi mathvariant="normal">U</mml:mi> </mml:mrow> </mml:math> , respectively. The average wavelength sensitivity is 12,750 nm/RIU in the refractive index range of 1.306–1.386. This advanced sensor is suitable for the determination of RIs in the near-infrared region.
[ital CP] violation in the [ital B][sup 0] meson system: A crucial test of the standard model (1991)

[ital CP] violation in the electroweak interactions, basic to our understanding of cosmology and particle physics, has been experimentally established for nearly three decades, but we still have no understanding of the phenomenon. A new class of experiments which measure [ital CP]-violating asymmetries in the [ital B][sup 0] system using an asymmetric [ital e][sup +][ital e[minus]] storage ring, promises to distinguish between alternative models.
Equilibriums for the reaction of cysteine and derivatives with formaldehyde and protons (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEquilibriums for the reaction of cysteine and derivatives with formaldehyde and protonsRoland G. KallenCite this: J. Am. Chem. Soc. 1971, 93, 23, 6227–6235Publication Date (Print):November 1, 1971Publication History Published online1 May 2002Published inissue 1 November 1971https://pubs.acs.org/doi/10.1021/ja00752a039https://doi.org/10.1021/ja00752a039research-articleACS PublicationsRequest reuse permissionsArticle Views395Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chicken major histocompatibility complex class II molecules of the B19 haplotype present self and foreign peptides (2006)

The chicken major histocompatibility complex (MHC), or B-complex, mediates genetic resistance and susceptibility to infectious disease. For example, the B19 haplotype is associated with susceptibility to Marek's disease. Here, we describe the sequencing and analysis of peptides presented by B19 MHC class II molecules. A B19/B19 B-cell line was used for the immunoaffinity purification of MHC class II molecules, which was followed by acid elution of the bound peptides. The eluted peptides were then analysed using tandem mass spectrometry. Thirty peptide sequences were obtained, ranging from 11 to 25 amino acids in length. Source protein cellular localization included the plasma membrane, cytosol and endosomal pathway. In addition, five peptides from the envelope glycoprotein of chicken syncytial virus (CSV) were identified. Chicken syncytial virus had been used as a helper virus along with reticuloendotheliosis virus strain T for transformation of B19/B19B cells. Alignment and analysis of the peptide sequence pool provided a putative peptide-binding motif for the B19 MHC class II.
Mutations in the SLC34A2 Gene are Associated with Pulmonary Alveolar Microlithiasis (2006)

Mutations in the SLC34A2 gene that abolish normal gene function cause pulmonary alveolar microlithiasis.
Alterations in macromolecular composition and cell wall integrity by ciprofloxacin in Mycobacterium smegmatis (1999)

The present study has been undertaken to explore the biochemical mechanism of antimycobacterial action of a potent fluoroquinolone i.e. ciprofloxacin in Mycobacterium smegmatis. Cells grown in the presence of a subinhibitory concentration (IC50) of ciprofloxacin had a significantly lower content of all the major macromolecules i.e. DNA, RNA, proteins and lipids with maximum inhibition in DNA concentration as compared to control. Significant quantitative changes were also observed in the various chemical constituents of cell wall of ciprofloxacin grown cells. A decrease in the number of binding sites for a fluorescent probe L-anilinonapthalene-8-sulphonate (ANS) in ciprofloxacin grown cells suggested structural changes on the cell surface. Significant changes were also observed in the morphology of cells grown in the presence of ciprofloxacin by scanning electron microscopy (SEM). Our results suggest that ciprofloxacin exerts its antimycobacterial activity by affecting the cell wall as well as various macromolecules, particular DNA, the vital component for cell survival and growth.
Epidermodysplasia verruciformis in an HIV-infected man: a case report and review of the literature. (2012)

Epidermodysplasia verruciformis (EV) is a rare genodermatosis, first described by Lewandosky and Lutz in 1922.1 This premalignant lesion has occurred de novo, as well as in patients with impaired cell-mediated immunity, including those infected with HIV, systemic lupus erythematosus2 (SLE), or lymphoma,3 or those who have received a solid organ transplant.4 In immunocompromised and immunocompetent populations, typical clinical findings are similar, and include pityriasis versicolor-like macules, as well as flat papules and lesions resembling verruca plana. Characteristic histologic features of the disease are the coexistence of epidermal thickening, a loose horny layer with a basketweave–like appearance, and the presence of large cells in the spinous and granular layers of the skin, presenting with a large blue-gray cytoplasm often associated with a perinuclear halo.5,6
Experimental study on combined natural and gas-injection enhanced circulation (2004)

Abstract The paper summarises the experimental results obtained in the frame of a research concerning natural and gas-injection enhanced circulation. These phenomena, having an interest for cooling accelerator driven subcritical reactor core systems (ADSs), are addressed making use of a downscaled facility presently operating with water, as a coolant fluid, and air, as gas injected to obtain gas-lifting. Previously published data from the research addressed separately the phenomena of natural circulation and of gas-injection enhanced circulation, comparing the experimental data with RELAP5 code predictions. After a description of the experimental facility and a summary of the previous experimental results, the present work discusses data obtained in experiments in which buoyancy due to temperature differences and voiding generated by air injection are combined. Different air injection flow rates and heating powers are used in this purpose. The quantitative trends obtained in the experiments are analysed and discussed. The expected overwhelming effect of gas-injection enhanced circulation with respect to natural circulation is one of the outcomes of the experimental data in the investigated range of parameters.
HOOKED: A GAME FOR DISCOVERING WHAT MAKES MUSIC CATCHY (2013)

Although there has been some empirical research on earworms, songs that become caught and replayed in one’s memory over and over again, there has been surprisingly little empirical research on the more general concept of the musical hook, the most salient moment in a piece of music, or the even more general concept of what may make music ‘catchy’. Almost by definition, people like catchy music, and thus this question is a natural candidate for approaching with ‘gamification’. We present the design of Hooked, a game we are using to study musical catchiness, as well as the theories underlying its design and the results of a pilot study we undertook to check its scientific validity. We found significant di↵erences in time to recall pieces of music across di↵erent segments, identified parameters for making recall tasks more or less challenging, and found that players are not as reliable as one might expect at predicting their own recall performance.
Molecular characterisation of longitudinally collected circulating cell-free DNA in HPV+ve and HPV-ve oropharyngeal cancer (2020)

Abstract Oropharyngeal squamous cell carcinoma (OPSCC) is an increasing global health problem and is divided into two types dependent on association with human papillomavirus (HPV), with a more favourable prognosis in virus-associated tumours. Current methods of establishing viral aetiology, assessing response to therapy and clinical monitoring rest on tissue biopsy, clinical examination and post-treatment imaging. However, tissue biopsy is invasive and carries significant risk of morbidity, and post-treatment scans are frequently indeterminate. Analysis of cell-free DNA (cfDNA) from the circulation provides a minimally invasive method for detecting and monitoring cancer-derived DNA fragments, with the potential for enhancing clinical care. Through the longitudinal collection of 166 blood samples in 67 OPSCC patients we evaluate the utility of three cfDNA analysis methods: droplet digital PCR (ddPCR) and fragment size analysis in both HPV+ve and HPV-ve disease, and ultra-deep sequencing in patients with HPV-ve disease. We show that ddPCR analysis of cfDNA for five HPV types (16, 18, 31, 33 &amp; 35) is strongly concordant with existing clinical assays (p16 immunohistochemistry (IHC) and quantitative PCR analysis of solid tumour tissue) and that cfDNA fragment size was reduced in OPSCC patients compared to healthy controls. Sequential ddPCR measurements of cfDNA HPV copy number showed a decrease to undetectable levels in all 30 HPV+ve patients in at least one of their post-treatment samples and a corresponding increase in cfDNA fragment size in patients who had a complete response to chemoradiotherapy. In two HPV+ve patients, clinical decision-making based on HPV ddPCR of cfDNA may have led to earlier detection of relapse in one patient or avoided surgical exploration in a second patient, which led to resection of tissue that did not harbour malignancy. In HPV-ve disease, ultra-deep sequencing identified tumour-derived somatic mutations of circulating cfDNA in genes such as TP53 and members of the ERBB family that are potential markers of therapeutic responsiveness and patient prognosis. Together our data suggest that analysis of circulating cfDNA can enhance current clinical strategies for assessing therapeutic response and disease monitoring in both HPV+ve and HPV-ve OPSCC.
Feasibility study of heavy oil recovery in the Permian Basin (Texas and New Mexico) (1993)

This report is one of a series of publications assessing the feasibility of increasing domestic heavy oil production. Each report covers select areas of the United States. The Permian Basin of West Texas and Southeastern New Mexico is made up of the Midland, Delaware, Val Verde, and Kerr Basins; the Northwestern, Eastern, and Southern shelves; the Central Basin Platform, and the Sheffield Channel. The present day Permian Basin was one sedimentary basin until uplift and subsidence occurred during Pennsylvanian and early Permian Age to create the configuration of the basins, shelves, and platform of today. The basin has been a major light oil producing area served by an extensive pipeline network connected to refineries designed to process light sweet and limited sour crude oil. Limited resources of heavy oil (10'' to 20'' API gravity) occurs in both carbonate and sandstone reservoirs of Permian and Cretaceous Age. The largest cumulative heavy oil production comes from fluvial sandstones of the Cretaceous Trinity Group. Permian heavy oil is principally paraffinic and thus commands a higher price than asphaltic California heavy oil. Heavy oil in deeper reservoirs has solution gas and low viscosity and thus can be produced by primary and by waterflooding. Because of the nature of the resource, the Permian Basin should not be considered a major heavy oil producing area.
GaN-Based Surface-Emitting Lasers Using Micro-Facets Fabricated by Selective-Area Epitaxy (2007)

GaN microfacets have been grown by selective-area metalorganic vapor phase epitaxy (SA-MOVPE) and applied to GaN-based surface-emitting lasers. The crystal orientation of the microfacets was strictly controlled by the shapes of the mask-openings and growth conditions so that vertical and inclined microfacets were obtained. Hexagonal microprisms (HMPs) of GaN with 5-50μm in diameters have extremely smooth vertical side walls of GaN {10 1 0} microfacets. These GaN HMPs lase by optical pumping and have the inscribed hexagonal optical paths. Additionally, GaN-based horizontal cavity surface-emitting lasers (HCSELs) were successfully fabricated. The GaN-based HCSELs have Fabry-Perot cavity and outer micromirrors, which consist of SA-MOVPE grown {11 2 0} vertical and {11 2 2} inclined microfacets, and lased at room temperature by pulsed current injection. The laser beam emitted laterally from a Fabry-Perot cavity {11 2 0} vertical micromirror is reflected by a {11 2 2} inclined outer micromirror so as to be directed upward. The GaN-based HCSEL has a current-confining structure because the incorporation probability of p-type dopants (Mg) is strongly influenced by facet orientation (growth direction).