gebhart/patrepeval huggingface dataset:
Report of the Committee on Research Enhancement & Transformational Research Collaboration; executive summary (2010)

The University of New Mexico's Office of Research created a committee to study the potential to stimulate cross- and trans-disciplinary research through a planned strategic initiative. This was seen as an important campus research value to capitalize on the emerging grant opportunities provided by data intensive cyber-enabled research and to solve environmental and other global challenges through joint humanities and science approaches.
Impact of organic contamination on 1064-nm laser-induced damage threshold of dielectric mirrors (2006)

The lifetime of optical components submitted to high laser fluences is degraded under organic contaminant environment. The molecular background of the Ligne d'Integration Laser (LIL), prototype of the future Laser Megajoule, might reduce the laser damage threshold of exposed fused silica surfaces. This paper reports the interaction effects between pure model contaminant deposits and a pulsed 1064 nm laser radiation on the coming out of mirror damage. The experimental setup allowed us to condense nanolayers of model contaminants on optics, the deposit impacts were then investigated by Laser Induced Damage Threshold (LIDT) tests in Rasterscan mode. In order to highlight physical processes emphasizing the emergence of optics damage, we characterized the irradiated deposit using interferometric microscopy analysis and spectrophotometric analysis. The challenge was to determine physical and phenomenological processes occurring during the irradiation of a pure contaminant deposit with a 1064 nm pulsed laser and to study the impact of this model contaminant on the LIDT of dielectric SiO<sub>2</sub>/HfO<sub>2</sub> mirrors.
Report Writing (2014)

This chapter conveys what makes a good report, showing how a typical report should be organized and including elements that may or may not appear in every report, such as the introduction, background and information from others, observations, analysis, discussion, conclusions, recommendations, disclaimers, and reference sections, some of which may include several subsections and relevant websites. A good report is clear, well organized, and accessible to its audience. The chapter begins with a discussion of style. Useful reference books on style include The Elements of Style and The Chicago Manual of Style. The chapter argues for some suggestions that will improve a report's readability and better communicate its findings and provides general suggestions for how to organize an effective narrative.
Real-Time Screening of Biocatalysts in Live Bacterial Colonies (2017)

Screening of bacterial colonies to identify new biocatalytic activities is a widely adopted tool in biotechnology, but is constrained by the requirements for colorimetric or tag-based detection methods. Herein we report a label-free screening platform for biotransformations in live colonies using desorption electrospray ionization coupled with ion mobility mass spectrometry imaging (DiBT-IMMS). The screening method is demonstrated for both ammonia lyases and P450 monooxygenases expressed within live bacterial colonies and is shown to enable multiplexing of enzyme variants and substrate libraries simultaneously.
Virtual platform architectures for resource metering in datacenters (2009)

With cloud and utility computing models gaining significant momentum, data centers are increasingly employing virtualization and consolidation as a means to support a large number of disparate applications running simultaneously on a CMP server. In such environments, it is important to meter the usage of resources by each datacenter application so that customers can be charged accordingly. In this paper, we describe a simple metering and chargeback model (pay-as-you-go) and describe a solution based on virtual platform architectures (VPA) to accurately meter visible as well as transparent resources.
Advances in Cardiac Cellular Electrophysiology: Implications for Automaticity and Therapeutics (1988)

Over the past two decades, deadly coronaviruses, with the most recent being the severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) 2019 pandemic, have majorly challenged public health. The path for virus invasion into humans and other ...Read More
The cytotoxin of Actinobacillus pleuropneumoniae (pleurotoxin) is distinct from the haemolysin and is associated with a 120 kDa polypeptide (1991)

Mutants of Actinobacillus pleuropneumoniae strain HK 361 (serotype 2) were isolated which were deficient in type II (Ca2(+)-dependent) haemolysin activity (Hly-). Some of the Hly- mutants secreted a potent, heat-labile extracellular cytotoxic activity against porcine alveolar macrophages. Comparison of cell-free culture supernatant from the parent strain and some Hly- mutants by SDS-PAGE and immunoblotting revealed the loss of a major extracellular polypeptide of 109 kDa. Two Hly- mutants which in addition failed to secrete a 120 kDa polypeptide produced no extracellular cytotoxic activity, suggesting that the 120 kDa protein was the cytotoxin. Antiserum raised to the culture supernatant from a Hly- mutant lacking the 109 kDa polypeptide recognized the 120 kDa band, but not the 109 kDa band, in immunoblots and neutralized the cytotoxic activity, but not the haemolytic activity, of A. pleuropneumoniae. The 120 kDa polypeptide and extracellular cytotoxic activity were widespread among A. pleuropneumoniae strains, but absent from related bacterial pathogens of the pig: Actinobacillus suis, Haemophilus parasuis and Pasteurella multocida. A clear correlation was found between the presence of the 120 kDa polypeptide and cytotoxic activity in culture supernatants. The cytotoxic activity of all the strains tested was neutralized by antibody to the Hly- extracellular material and by convalescent pig serum. It is proposed that the 120 kDa polypeptide represents the cytotoxin of A. pleuropneumoniae, that it is distinct from the haemolysin, and that it be termed pleurotoxin.
A High-Throughput Phenotypic Screen of Cytotoxic T Lymphocyte Lytic Granule Exocytosis Reveals Candidate Immunosuppressants (2014)

We screened the National Institutes of Health's Molecular Libraries Small Molecule Repository for inhibitors of cytotoxic T lymphocyte (CTL) lytic granule exocytosis by measuring binding of an antibody in the extracellular solution to a lysosomal membrane protein (LAMP-1) that is transferred to the plasma membrane by exocytosis. We used TALL-104 human leukemic CTLs stimulated with soluble chemicals. Using high-throughput cluster cytometry to screen 364,202 compounds in a 1536-well plate format, we identified 2404 initial hits: 161 were confirmed on retesting, and dose-response measurements were performed. Seventy-five of those compounds were obtained, and 48 were confirmed active. Experiments were conducted to determine the molecular mechanism of action (MMOA) of the active compounds. Fifteen blocked increases in intracellular calcium >50%. Seven blocked phosphorylation of extracellular signal-regulated kinase (ERK) by upstream mitogen-activated protein kinase kinases >50%. One completely blocked the activity of the calcium-dependent phosphatase calcineurin. None blocked ERK catalytic activity. Eight blocked more than one pathway. For 8 compounds, we were unable to determine an MMOA. The activity of 1 of these compounds was confirmed from powder resupply. We conclude that a screen based on antibody binding to CTLs is a good means of identifying novel candidate immunosuppressants with either known or unknown MMOAs.
A New Methodology for Evaluating Guidance Systems for Agricultural Vehicles (2006)

Evaluation of new technologies in agricultural machinery guidance is very important and can help producers choose the right equipment for their applications. At present, comparison between different guidance systems has typically been based on the amount of guidance error (i.e., the deviation of the vehicle from the desired path). This paper proposes a new methodology for evaluating these guidance systems. An RTK-GPS was used to record the exact location of a tractor while the operator used one of seven lightbar guidance systems to drive along parallel passes in the field. Frequency-domain analysis of the tractor path was used to compare the performance of the seven systems. Fourier analysis of the tractor path was performed by dividing the changes in the tractor path into low-, medium-, and high-frequency changes. Guidance systems with lower driving error have more high-frequency changes in the tractor path. This means that there is a tradeoff between the driving accuracy and operator workload. It is suggested that a comparison of the frequency spectrum of the tractor path can be used to better evaluate or compare agricultural guidance systems.
Chemical analysis of particle size fractions from glass melting furnaces. Final report (1981)

The purpose of this research was to identify the size fraction distribution of the various chemical constituents of glass furnace emissions. This would assist researchers in identifying emissions characteristic of glass furnaces; thus, providing design requirements for control technology development programs. The analysis included mass of particulate emissions, particulate size distributions, and analysis of trace metals concentrations in each size fractions.
Analysis and Design of Millimeter-Wave Low-Voltage CMOS Cascode LNA With Magnetic Coupled Technique (2012)

In this paper, the design and analysis of CMOS low-noise amplifiers (LNAs) with a magnetic coupled technique in different cascode topologies are proposed. To minimize the noise figure (NF) and the supply voltage, and to guarantee large 3-dB bandwidth, transformers are designed and placed between the transistors of the cascode devices. Three low supply voltage and wideband LNAs are designed, fabricated, and tested for demonstration. The first LNA uses the magnetic coupled cascode configuration. The second LNA is consisted of magnetic coupled cascode configuration with two amplification stages. The third one-stage LNA is based on the magnetic coupled triple cascode configuration. The first LNA is designed at <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</i> -band while the others are designed at <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> -band, using 90-nm low-power CMOS technology. The <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</i> -band LNA has a gain of 13.8 dB and an NF of 3.8 dB at 37 GHz, with a power consumption of 18 mW at 1.2-V supply voltage. The <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> -band cascode LNA has a gain of 17 dB at 57 GHz and an NF of 4.4 dB at 59.5 GHz with a power consumption of 19.2 mW at 1.2-V supply voltage. The <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> -band triple-cascode LNA has a gain of 13.7 dB at 54 GHz and an NF of 5.3 dB at 59.5 GHz, with a power consumption of 14.4 mW at 1.2-V supply voltage. Compared with the conventional cascode LNAs, the proposed magnetic coupled cascode LNAs have better NF, larger gain bandwidth product, and lower power consumption. The use of the magnetic coupled technique in a multicascode LNA significantly improves the gain performance with a slight degradation of the NF.
Precise Engineering of Nanocrystal Shells via Colloidal Atomic Layer Deposition (2017)

We present a general strategy for a facile synthesis of complex multifunctional nanoscale materials via colloidal atomic layer deposition (c-ALD). The c-ALD technique is based on self-limiting half-reactions of ionic precursors on the surface of a nanocrystal (NC) occurring at room temperature. Using this technique, uniform layers of CdS and ZnS semiconductor shells were epitaxially grown on CdSe semiconductor cores with different shell combinations, leading to the precise control of the optical properties of these heterostructures. All core–shell multicomponent nanoparticles preserve narrow size distributions, phase crystallinity, and shape homogeneity of the initial NCs. Furthermore, we attempted to extend the toolbox of the c-ALD to combine materials with intrinsically different properties, such as Au/CdS core/shell structures with substantial lattice mismatch. The results presented in this work demonstrate great opportunities for creating functional materials with programmable properties for electronics and optoelectronics.
Reducing the Sampling Frequency of Groundwater Monitoring Wells (1995)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTReducing the Sampling Frequency of Groundwater Monitoring WellsVirginia M. Johnson, R. Cary Tuckfield, Maureen N. Ridley, and Rachel A. AndersonView Author Information Environmental Restoration Program, Lawrence Livermore National Laboratory, L-206, P.O. Box 808, Livermore, California 94551, and Savannah River Technology Center, Westinghouse Savannah River Company, P.O. Box 616, Aiken, South Carolina 29802 Cite this: Environ. Sci. Technol. 1995, 30, 1, 355–358Publication Date (Print):December 1, 1996Publication History Received16 May 1995Accepted3 November 1995Revised23 October 1995Published online27 December 1995Published inissue 1 December 1996https://pubs.acs.org/doi/10.1021/es950335uhttps://doi.org/10.1021/es950335ureview-articleACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views340Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Computer simulations,Groundwaters,Impurities,Power,Redox reactions Get e-Alerts
Multipurpose vaginal rings for HIV prevention and non-hormonal contraception (2022)

Vaginal rings releasing antiretrovirals - either alone or in combination with contraceptive progestins - are being developed for contraception and prevention of human immunodeficiency virus (HIV) transmission via vagina. However, hormonal contraceptives are associated with numerous side effects and contraindications, and many women are interested in using hormone-free contraceptives. The aim of this project is to develop multipurpose vaginal rings to release copper and/or zinc ions and dapivirine over a month for contraception and HIV prevention. Ring manufacture, swell testing, and in vitro drug release testing have been conducted. The experimental results obtained currently are encouraging and support the continued development of these ring formulations as a novel and interesting multipurpose prevention technology strategy.
3Q1446 Mechanism of green/red photoconversion of phytochromerelated photoreceptor(Photobiology : Vision & Photoreception4,The 49th Annual Meeting of the Biophysical Society of Japan) (2011)

TheBiophysicalSociety of Japan General IncorporatedAssociation in the presence ofsubstrate, whjch was sirnitar to the case in (6-4) PHR [1], but the frequency change was opposite, Molecular mechanism of photoactivation and phetorepair will be discussed on the basis oF th ¢ spectral comparison between CPD and {6-4) PHR.
Particle Surface Layer Characterization Using Ion Beam Analysis. (1996)

Abstract : Surface contaminants on powders used in powder metallurgy and ceramics processing can be responsible for serious degradation of the product properties. The elimination of such contamination, or at least the tailoring of its properties for improved performance, requires the ability to determine its nature accurately. Ion beam analysis techniques are used to provide quantitative characterization of such contamination. In this report, we describe two methods for adapting well-known backscattering spectroscopy techniques for use on samples consisting of small spherical or cylindrical particles. The limitations and relative strengths and weaknesses, of each method will be discussed. Examples of the use of these methods in conjunction with Rutherford Backscattering Spectroscopy will be shown, although they are also applicable to other types of ion beam analysis.
Silica-based functional fibers with enhanced nonlinearity and their applications (1999)

Silica-based optical fibers are now being used in various applications which utilize nonlinear effects in fiber. In addition to enhancing nonlinearity of optical fibers, tailoring chromatic dispersion is one of the important design issues in such applications. Highly nonlinear dispersion-shifted fibers have been developed, and a very compact wavelength converter module has been demonstrated by using the fiber. Dispersion-flattened and dispersion-decreasing fibers have also been proved to be highly effective for supercontinuum generation.
Nanoparticle Motion within Glassy Polymer Melts (2009)

X-ray photon correlation spectroscopy is employed to investigate the motion of dilute suspensions of gold nanoparticles in low-molecular-weight polystyrene melts. At high temperatures, the observed motion is diffusive, with a rate that follows a Vogel-Fulcher temperature dependence. Closer to the glass transition temperature Tg, diffusion is superseded by a hyperdiffusive process that first becomes observable near a crossover temperature Tc approximately 1.1Tg and is identified with heterogeneous strain in the melts. Following rapid cooling to temperatures sufficiently below Tc, but still above Tg, the hyperdiffusive dynamics displays a time dependence similar to aging in polymer glasses.
High-Fidelity Permeability and Porosity Prediction Using Deep Learning With the Self-Attention Mechanism (2022)

Accurate estimation of reservoir parameters (e.g., permeability and porosity) helps to understand the movement of underground fluids. However, reservoir parameters are usually expensive and time-consuming to obtain through petrophysical experiments of core samples, which makes a fast and reliable prediction method highly demanded. In this article, we propose a deep learning model that combines the 1-D convo- lutional layer and the bidirectional long short-term memory network to predict reservoir permeability and porosity. The mapping relationship between logging data and reservoir parameters is established by training a network with a combination of nonlinear and linear modules. Optimization algorithms, such as layer normalization, recurrent dropout, and early stopping, can help obtain a more accurate training model. Besides, the self-attention mechanism enables the network to better allocate weights to improve the prediction accuracy. The testing results of the well-trained network in blind wells of three different regions show that our proposed method is accurate and robust in the reservoir parameters prediction task.
Communication—Improving Optoelectronic Properties of Electrochemically Deposited Cuprous Oxide Thin-Films by Low-Temperature Post-Deposition Annealing (2017)

The effect of low-temperature post-deposition annealing (PDA) on electrochemically deposited cuprous oxide (ECD-Cu2O) thin-films was investigated. The PDA at 150°C drastically improved optoelectronic properties of ECD-Cu2O films regardless of annealing atmosphere. The films exhibits free exciton luminescence at room temperature and a high hole mobility about 18 cm2/V·s. Moreover, the diffusion length of photo-generated carriers increased around two times compared to the as-deposited film. On the other hands, the PDA at 200°C significantly deteriorated the optoelectronic properties presumably due to the increase of mid-gap defects in the Cu2O films.
Internal optical loss measurements in 1.3 µmInGaAsP lasers (1995)

A highly accurate method of measuring optical loss in individual semiconductor lasers is presented and compared with other methods. Measured loss data for 1.3 µm semiconductor lasers are presented that illustrate the suitability of this technique for studying the dependence of loss on temperature and carrier density.
Thermal Stability of Proteins in Aqueous Polyol Solutions:  Role of the Surface Tension of Water in the Stabilizing Effect of Polyols (1998)

Polyols and sugars are known to increase the thermal stability of proteins in aqueous solutions and lead to their preferential hydration. While the mechanism of action of sugars has been proposed to be essentially due to the increase in the surface tension of water in their presence, polyols including glycerol have been reported to lower the surface tension of water and act via the solvophobic effect. Surface tension measurements of polyols in water carried out by us, on the contrary, indicate a substantial increase in the surface free energy of water. These increments are comparable to those found in the case of sugars. To investigate the role of the surface tension of the solvent medium on the thermal stability of proteins, we have carried out a comprehensive study on the effects of a series of polyols with varying numbers of hydroxyl groups and stereochemistry, such as mannitol, inositol, sorbitol, xylitol, and adonitol, on the thermal stability of five proteins varying in their physicochemical characteristics, viz., ribonuclease A, α-chymotrypsinogen, lysozyme, cytochrome c, and trypsin inhibitor. The studies have been carried out at pH 2.5, 4.0, and 7.0 to elucidate the contribution of the surface charges toward the polyol-mediated thermal stability of proteins. A very good correlation between an increase in the surface tension of water in the presence of a polyol and an increase in the themal stability of proteins has been observed. Correlation of the thermal stability of proteins with physicochemical properties such as net charge and net hydrophobic surface exposed on unfolding indicates that none of these properties is a dominant factor in governing protein thermal stability. The results indicate that polyol-induced water-mediated effects such as an increase in the surface tension of water play a major role in the stabilization of proteins and that the preferential hydration of proteins observed in their presence is a consequence of the increase in the surface free energy of water.
LexiPass methodology: a conceptual path from frames to senses and back. (2006)

In this paper we claim that an integration of FrameNet and WordNet will improve interoperability, user-friendliness and usability of both lexical resources. If the former provides a sophisticated representational structure compared to a narrow lexical coverage, the latter- on the other side- supplies a dense network of word senses and semantic relations although not supporting advanced accessibility (i.e., via frames). According to the integration perspective we present in the paper, we introduce LexiPass methodology, which combines Burchardt’s tool ‘WordNet Detour of FrameNet ’ with basic statistical analysis, enabling frame-guided search and extraction of domain synsets from WordNet.