gebhart/patrepeval huggingface dataset:
Instant Messaging or Instant Headache? (2004)

It’s a reality. You have IM (instant messaging) clients in your environment. You have already recognized that it is eating up more and more of your network bandwidth and with Microsoft building IM capability into its XP operating system and applications, you know this will only get worse. Management is also voicing concerns over the lost user productivity caused by personal conversations over this medium. You have tried blocking these conduits for conversation, but it is a constant battle. Tools are now available to make this blocking job easier, such as those from Akonix, FaceTime Communications, and NetIQ, but IM is maturing, and your users are starting to depend on it as an essential business tool.
Posteromediale Unterschenkelverbiegung und Neuroblastom bei Verdacht auf Neurofibromatose Typ I: Kasuistik und Literaturübersicht (2004)

The posteromedial bowing of the lower leg seems to affect more boys as well as the left side. As far as described in all but one case it was the first delivery. Regularly, a limb shortening and pes calcaneovalgus is to be found. 99 children were treated conservatively, 21 got an operation of the affected side. In 19 performed osteotomies no pseudarthrosis occurred. One case of a fracture due to an adequate trauma without healing problems is described.
Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time (2020)

DNA single strand breaks (SSBs) are one of the most frequent DNA lesions in genomic DNA generated either by oxidative stress or during the base excision repair pathways. Here we established a new real-time assay to assess an imbalance of DNA SSB repair by indirectly measuring PARP-1 activation through the depletion of intracellular NAD(P)H. A water-soluble tetrazolium salt is used to monitor the amount of NAD(P)H in living cells through its reduction to a yellow colored water-soluble formazan dye. While this assay is not a direct method, it does not require DNA extraction or alkaline treatment, both of which could potentially cause an artifactual induction of SSBs. In addition, it takes only 4 h and requires less than a half million cells to perform this measurement. Using this assay, we demonstrated that the dose- and time-dependent depletion of NAD(P)H in XRCC1-deficient CHO cells exposed to methyl methanesulfonate. This decrease was almost completely blocked by a PARP inhibitor. Furthermore, methyl methanesulfonate reduced NAD(P)H in PARP-1+/+cells, whereas PARP-1–/– cells were more resistant to the decrease in NAD(P)H. These results indicate that the analysis of intracellular NAD(P)H level using water-soluble tetrazolium salt can assess an imbalance of SSB repair in living cells in real time.
Phosphorylation of theDictyostelium myosin II heavy chain is necessary for maintaining cellular polarity and suppressing turning during chemotaxis (1998)

Conversion of the three mapped threonine phosphorylation sites in the myosin II heavy chain tail to alanines results in a mutant (3XALA) in Dictyostelium discoideum, which displays constitutive myosin overassembly in the cytoskeleton and increased cortical tension. To assess the importance of myosin phosphorylation in cellular translocation and chemotaxis, 3XALA mutant cells have been analyzed by 2D and 3D computer-assisted methods in buffer, in a spatial gradient of cAMP, and after the rapid addition of cAMP. 3XALA cells crawling in buffer exhibit distinct abnormalities in cellular shape, the maintenance of polarity and the complexity of the pseudopod perimeter. 3XALA cells crawling in buffer also exhibit a decrease in directionality. In a spatial gradient of cAMP, the behavioral defects are accentuated. In a spatial gradient, 3XALA cells exhibit a repeating 1- to 2-min behavior cycle in which the shape of each cell changes abnormally from elongate to extremely wide with lateral, opposing pseudopods. At the end of each cycle, 3XALA cells turn 90 degrees into the left or right lateral pseudopod, resulting in a dramatic depression in chemotactic efficiency, even though 3XALA cells are chemotactically responsive to cAMP. These results demonstrate that the phosphorylation of myosin II heavy chain plays a critical role in the maintenance of cell shape and in persistent translocation in a spatial gradient of chemoattractant.
Hydroformylation Catalysis by Arylphosphine Complexes of Rhodium (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydroformylation Catalysis by Arylphosphine Complexes of RhodiumJ. H. Craddock, Arnold Hershman, F. E. Paulik, and J. F. RothCite this: Ind. Eng. Chem. Prod. Res. Dev. 1969, 8, 3, 291–297Publication Date (Print):September 1, 1969Publication History Published online1 May 2002Published inissue 1 September 1969https://pubs.acs.org/doi/10.1021/i360031a016https://doi.org/10.1021/i360031a016research-articleACS PublicationsRequest reuse permissionsArticle Views109Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Sorption of Sb(III) and Sb(V) to Goethite:  Influence on Sb(III) Oxidation and Mobilization (2006)

Antimony is an element of growing interest for a variety of industrial applications, even though Sb compounds are classified as priority pollutants by the Environmental Protection Agency of the United States. Iron (Fe) hydroxides appear to be important sorbents for Sb in soils and sediments, but mineral surfaces can also catalyze oxidation processes and may thus mobilize Sb. The aim of this study was to investigate whether goethite immobilizes Sb by sorption or whether Sb(III) adsorbed on goethite is oxidized and then released. The sorption of both Sb(III) and Sb(V) on goethite was studied in 0.01 and 0.1 M KClO4 M solutions as a function of pH and Sb concentration. To monitor oxidation processes Sb species were measured in solution and in the solid phase. The results show that both Sb(III) and Sb(V) form inner-sphere surface complexes at the goethite surface. Antimony(III) strongly adsorbs on goethite over a wide pH range (3-12), whereas maximum Sb(V) adsorption is found below pH 7. At higher ionic strength, the desorption of Sb(V) is shifted to lower pH values, most likely due to the formation of ion pairs KSb(OH)6 degrees. The sorption data of Sb(V) can be fitted by the modified triple-layer surface complexation model. Within 7 days, Sb(III) adsorbed on goethite is partly oxidized at pH 3, 5.9 and 9.7. The weak pH-dependence of the rate coefficients suggests that adsorbed Sb(III) is oxidized by 02 and that the coordination of Sb(III) to the surface increases the electron density of the Sb atom, which enhances the oxidation process. At pH values below pH 7, the oxidation of Sb(III) did not mobilize Sb within 35 days, while 30% of adsorbed Sb(III) was released into the solution at pH 9.9 within the same time. The adsorption of Sb(III) on Fe hydroxides over a wide pH range may be a major pathway for the oxidation and release of Sb(V).
Use of a vertical transarticular pin for stabilization of severe ankle fractures. (2003)

Transarticular pin fixation has been used successfully to stabilize severe ankle fractures. This technique is most commonly used as provisional fixation until internal fixation is appropriate. In addition, transarticular pin fixation can be a supplement in cases involving persistent tibiotalar instability after internal fixation and can provide sole definitive fixation of arthritic and osteoporotic ankles. In this article, we describe the surgical technique, report results, and review when transarticular pin fixation may be appropriate. We believe that all orthopedic surgeons should know this technique--especially those treating cases of complex orthopedic trauma.
Inhibition of Histone Demethylase JMJD1A Improves Anti-Angiogenic Therapy and Reduces Tumor-Associated Macrophages (2013)

Antiangiogenic strategies can be effective for cancer therapy, but like all therapies resistance poses a major clinical challenge. Hypoxia and nutrient starvation select for aggressive qualities that may render tumors resistant to antiangiogenic attack. Here, we show that hypoxia and nutrient starvation cooperate to drive tumor aggressiveness through epigenetic regulation of the histone demethylase JMJD1A (JHDM2A; KDM3A). In cancer cells rendered resistant to long-term hypoxia and nutrient starvation, we documented a stimulation of AKT phosphorylation, cell morphologic changes, cell migration, invasion, and anchorage-independent growth in culture. These qualities associated in vivo with increased angiogenesis and infiltration of macrophages into tumor tissues. Through expression microarray analysis, we identified a cluster of functional drivers such as VEGFA, FGF18, and JMJD1A, the latter which was upregulated in vitro under conditions of hypoxia and nutrient starvation and in vivo before activation of the angiogenic switch or the prerefractory phase of antiangiogenic therapy. JMJD1A inhibition suppressed tumor growth by downregulating angiogenesis and macrophage infiltration, by suppressing expression of FGF2, HGF, and ANG2. Notably, JMJD1A inhibition enhanced the antitumor effects of the anti-VEGF compound bevacizumab and the VEGFR/KDR inhibitor sunitinib. Our results form the foundation of a strategy to attack hypoxia- and nutrient starvation-resistant cancer cells as an approach to leverage antiangiogenic treatments and limit resistance to them.
Characteristics and Removal of Filter Cake Formed by Formate-Based Drilling Mud (2008)

Abstract Formate-based mud has been used to drill deep gas wells in Saudi Arabia since 2004. This mud typically contains XC-polymer, starch, polyanionic cellulose, and a relatively small amount of calcium carbonate particles. This mud (typically 90 pcf, pH of 10) is used to drill a deep sandstone reservoir (310°F). Various cleaning fluids were proposed to remove drilling mud filter cake; including: solids-free formate brine, formate brine doped with organic acids (acetic, formic, citric, and lactic acids), and enzymes. The main objective of this paper is to assess the effectiveness of these cleaning fluids in removing formate drilling mud filter cake. A dynamic HPHT cell was first used to determine characteristics of the formate mud filter cake. Drilling mud and completion fluids were obtained from the field. The experiments were conducted using ceramic disks at bottom hole conditions. Compatibility tests between formate brine and cleaning fluids were performed at 300°F and 500 psi using HPHT visual cells (see-through cells). Circulation of solids-free formate brine did not remove the external filter cake. Citric acid at 10 wt%, formic acid, and lactic acid were found to be incompatible with formate brine at room temperature. However, these acids were compatible with formate brine at temperatures greater than 122°F. Mixing of these acids with the formate in the field may cause operational problems. Only acetic acid and enzymes were compatible with formate brine. A formula was developed that is compatible at room and reservoir temperature. This formula was effective in removing filter cake. A corrosion inhibitor was added to protect downhole tubulars. This paper will discuss the development of this formula and all tests that led to its development.
Antioxidant and antibacterial activity of extract and phases from stems of Spartium junceum L. growing in Algeria (2016)

This work aimed to evaluate the antioxidant and antibacterial activities of the hydroalcoholic (80% methanol) extract and n -hexane ( n -Hex), chloroform (Chl), ethyl acetate (EtAc), and n -butanol ( n -But) phases from Spartium junceum L. stems collected inAlgeria. Preliminary phytochemical investigations on phenolic compounds have been carried out. The total phenolic content, spectrophotometrically determined, ranged from 71.8095 ± 3.7136 mg GAE/g (extract) to 0.0582 ± 0.0106 mg GAE/g ( n -Hex). By HPLC-PDA analysis flavonoids (flavone derivatives), p-hydroxybenzoic acid, p-hydroxycinnamic acid, and cinnamic acid derivatives were identified both in the extract and phases. S. junceum extract showed a noticeable free radical scavenging effect in the DPPH test (IC 50 = 0.6833 ± 0.0240 mg/mL), mild reducing power, and strong chelating activity (IC 50 = 0.2292 ± 0.0138 mg/mL). Among the phases, n -But displayed the best effect both in the DPPH test and reducing power assay, whereas n -Hex resulted the most active in the ferrous ions chelating activity assay. A positive relationship between DPPH radical scavenging activity and total phenolic content was found. Both the extract and phases exhibited antimicrobial activity against Gram-positive bacteria only. Staphylococcus aureus ATCC 6538 was the most susceptible strain (MIC range: 15.60-250.00 µg/mL), and the Chl phase showed the greatest efficacy. S. junceum extract resulted non-toxic against Artemia salina . The obtained results demonstrate the potential of S. junceum stems as safe sources of natural antioxidant and antimicrobial compounds.
Image Matching via Loopy RNN (2017)

Most existing matching algorithms are one-off algorithms, i.e., they usually measure the distance between the two image feature representation vectors for only one time. In contrast, human's vision system achieves this task, i.e., image matching, by recursively looking at specific/related parts of both images and then making the final judgement. Towards this end, we propose a novel loopy recurrent neural network (Loopy RNN), which is capable of aggregating relationship information of two input images in a progressive/iterative manner and outputting the consolidated matching score in the final iteration. A Loopy RNN features two uniqueness. First, built on conventional long short-term memory (LSTM) nodes, it links the output gate of the tail node to the input gate of the head node, thus it brings up symmetry property required for matching. Second, a monotonous loss designed for the proposed network guarantees increasing confidence during the recursive matching process. Extensive experiments on several image matching benchmarks demonstrate the great potential of the proposed method.
Delivery of Aerosolized Liposomal Amikacin as a Novel Approach for the Treatment of Nontuberculous Mycobacteria in an Experimental Model of Pulmonary Infection (2014)

Pulmonary infections caused by nontuberculous mycobacteria (NTM) are an increasing problem in individuals with chronic lung conditions and current therapies are lacking. We investigated the activity of liposomal amikacin for inhalation (LAI) against NTM in vitro as well as in a murine model of respiratory infection. Macrophage monolayers were infected with three strains of Mycobacterium avium, two strains of Mycobacterium abscessus, and exposed to LAI or free amikacin for 4 days before enumerating bacterial survival. Respiratory infection was established in mice by intranasal inoculation with M. avium and allowing three weeks for the infection to progress. Three different regimens of inhaled LAI were compared to inhaled saline and parenterally administered free amikacin over a 28 day period. Bacteria recovered from the mice were analyzed for acquired resistance to amikacin. In vitro, liposomal amikacin for inhalation was more effective than free amikacin in eliminating both intracellular M. avium and M. abscessus. In vivo, inhaled LAI demonstrated similar effectiveness to a ∼25% higher total dose of parenterally administered amikacin at reducing M. avium in the lungs when compared to inhaled saline. Additionally, there was no acquired resistance to amikacin observed after the treatment regimen. The data suggest that LAI has the potential to be an effective therapy against NTM respiratory infections in humans.
Indoor Large-Scale MIMO-Based RSSI Localization with Low-Complexity RFID Infrastructure (2020)

Indoor localization based on unsynchronized, low-complexity, passive radio frequency identification (RFID) using the received signal strength indicator (RSSI) has a wide potential for a variety of internet of things (IoTs) applications due to their energy-harvesting capabilities and low complexity. However, conventional RSSI-based algorithms present inaccurate ranging, especially in indoor environments, mainly because of the multipath randomness effect. In this work, we propose RSSI-based localization with low-complexity, passive RFID infrastructure utilizing the potential benefits of large-scale MIMO technology operated in the millimeter-wave band, which offers channel hardening, in order to alleviate the effect of small-scale fading. Particularly, by investigating an indoor environment equipped with extremely simple dielectric resonator (DR) tags, we propose an efficient localization algorithm that enables a smart object equipped with large-scale MIMO exploiting the RSSI measurements obtained from the reference DR tags in order to improve the localization accuracy. In this context, we also derive Cramer-Rao lower bound of the proposed technique. Numerical results evidence the effectiveness of the proposed algorithms considering various arbitrary network topologies, and results are compared with an existing algorithm, where the proposed algorithms not only produce higher localization accuracy but also achieve a greater robustness against inaccuracies in channel modeling.
Induced Pluripotent Stem Cells (iPSCs) and Gene Therapy: A New Era for the Treatment of Neurological Diseases (2021)

To date, gene therapy has employed viral vectors to deliver therapeutic genes. However, recent progress in molecular and cell biology has revolutionized the field of stem cells and gene therapy. A few years ago, clinical trials started using stem cell replacement therapy, and the induced pluripotent stem cells (iPSCs) technology combined with CRISPR-Cas9 gene editing has launched a new era in gene therapy for the treatment of neurological disorders. Here, we summarize the latest findings in this research field and discuss their clinical applications, emphasizing the relevance of recent studies in the development of innovative stem cell and gene editing therapeutic approaches. Even though tumorigenicity and immunogenicity are existing hurdles, we report how recent progress has tackled them, making engineered stem cell transplantation therapy a realistic option.
Meniscus coated high open-circuit voltage bi-layer solar cells (2012)

Neat bi-layer solar cells of a fullerene acceptor and a cyanine dye donor were prepared using meniscus coating. Meniscus coating is very material efficient and leads to high quality pinhole-free films. The cells exhibit high open circuit voltages of 1 volt, only 0.8 eV below the band gap of the cyanine dye. This is one of the smallest differences reported for organic solar cells and illustrates an almost optimal donor-acceptor energy level alignment.
Laterally connected ‘trimesogens’ (1995)

Lateral fixing of three rod-like 4,4″-didecyloxy-p-terphenyl-units gives liquid crystalline materials with a broad smectic A-mesophase and a considerably increased stability with respect to the nematic phase of the parent 4,4″-didecyloxy-2′-methyl-p-terphenyl.
Hypermethylation Silences Wnt Inhibitory Factor 1 in Nasopharyngeal Carcinoma (2006)

Restricted accessAbstractFirst published January 2006Hypermethylation Silences Wnt Inhibitory Factor 1 in Nasopharyngeal CarcinomaE.G. Thung, J. Chou, […], L. You, Z. Xu, and D.M. Jablons+2-2View all authors and affiliationsVolume 54, Issue 1_supplhttps://doi.org/10.1177/108155890605401S28
Acoustic transfer of protein crystals from agarose pedestals to micromeshes for high-throughput screening (2014)

Acoustic droplet ejection (ADE) is an emerging technology with broad applications in serial crystallography such as growing, improving and manipulating protein crystals. One application of this technology is to gently transfer crystals onto MiTeGen micromeshes with minimal solvent. Once mounted on a micromesh, each crystal can be combined with different chemicals such as crystal-improving additives or a fragment library. Acoustic crystal mounting is fast (2.33 transfers s(-1)) and all transfers occur in a sealed environment that is in vapor equilibrium with the mother liquor. Here, a system is presented to retain crystals near the ejection point and away from the inaccessible dead volume at the bottom of the well by placing the crystals on a concave agarose pedestal (CAP) with the same chemical composition as the crystal mother liquor. The bowl-shaped CAP is impenetrable to crystals. Consequently, gravity will gently move the crystals into the optimal location for acoustic ejection. It is demonstrated that an agarose pedestal of this type is compatible with most commercially available crystallization conditions and that protein crystals are readily transferred from the agarose pedestal onto micromeshes with no loss in diffraction quality. It is also shown that crystals can be grown directly on CAPs, which avoids the need to transfer the crystals from the hanging drop to a CAP. This technology has been used to combine thermolysin and lysozyme crystals with an assortment of anomalously scattering heavy atoms. The results point towards a fast nanolitre method for crystal mounting and high-throughput screening.
Supplementary Figure 1 from Pharmacokinetic Modeling of Tumor Bioluminescence Implicates Efflux, and Not Influx, as the Bigger Hurdle in Cancer Drug Therapy (2023)

Supplementary Figure 1 from Pharmacokinetic Modeling of Tumor Bioluminescence Implicates Efflux, and Not Influx, as the Bigger Hurdle in Cancer Drug Therapy
Repression of Oct-4 during embryonic cell differentiation correlates with the appearance of TRIF, a transiently induced DNA-binding factor. (1999)

The Oct-4 gene encodes a transcription factor that is essential for maintaining the mouse germline. It is expressed during the earliest stages of embryogenesis, is downregulated during gastrulation, and is thereafter constrained to the germ cell lineage. Retinoic acid induced differentiation of embryonal carcinoma cells is also accompanied by a decrease in Oct-4 expression. We have previously shown that downregulation of Oct-4 expression is mediated by a hormone regulatory element (HRE). This element is located within the basal promoter and overlaps with a GC box that is crucial for Oct-4 promoter activity. The HRE is composed of three direct repeats with 1 and 0 spacing. In this study, we demonstrate that the doublet of direct repeats with 0 spacing (DR0) is bound by two novel factors. The initial repression of Oct-4 by retinoic acid coincides with the disappearance of the first factor (named UCF for undifferentiated cellular factor) and the appearance of a transiently induced factor (TRIF) which forms a larger complex with DR0 in electrophoretic mobility shift assays. These observations support the hypothesis that downregulation of the Oct-4 gene during early mouse embryogenesis involves the repression of its promoter by TRIF.