gebhart/patrepeval huggingface dataset:
Increased therapeutic efficacy induced by tumor necrosis factor alpha combined with platinum complexes and whole-body hyperthermia in rats. (1992)

This study examined the effect of a trimodality therapy of the combination of recombinant human tumor necrosis factor alpha (TNF), whole-body hypertheria (WBH), and cis-diamminedichloroplatinum(II) (CDDP) or cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) (CBDCA) on a fibrosarcoma and normal tissue in F344 rats. TNF (1 x 10(5) units/kg) increased the antitumor effect of both CDDP (1.5 mg/kg) + WBH (2 h at 41.5 degrees C) and CBDCA (30 mg/kg) + WBH. Tumor growth delay, which was 1.9 days for CDDP + WBH and 2.7 days for CBDCA + WBH (P less than 0.01 compared to control), was significantly increased to 2.9 days with TNF + CDDP + WBH and 5.4 days with TNF + CBDCA + WBH (P less than 0.05). WBH, TNF, CDDP or CBDCA alone, TNF + CDDP, TNF + CBDCA, or TNF + WBH had no significant effect on tumor growth. In contrast, administration of TNF did not enhance the CDDP- or CBDCA-mediated dose limiting normal tissue toxicity. CDDP + WBH-mediated acute renal injury and CBDCA + WBH-mediated acute myelosuppression, as determined by blood urea nitrogen and peripheral blood cell counts, respectively, were not increased with the addition of TNF to either dual modality therapy. Histopathologically, addition of TNF produced no significant alterations in the kidney and the bone marrow as compared to CDDP + WBH or CBDCA + WBH. These data show that TNF enhanced the platinum + WBH-mediated antitumor effect without increasing normal tissue toxicity, suggesting that TNF may increase the therapeutic efficacy of CDDP or CBDCA combined with WBH.
Voltammetric determination of surface active compounds at Au and Pt ultramicroelectrodes in flowing solutions (1997)

A new detection method was developed that takes advantage of changes in cyclic voltammograms (recorded with either a platinum or a gold ultramicroelectrode) caused by the adsorption, of inorganic and organic molecules. These changes may include reduction or oxidation of the adsorbate, inhibition of oxygen adsorption, inhibition of hydrogen adsorption, and also changes in the charging current. The detection is carried out in a stripping mode after the accumulation of analyte on the electrode surface for 50–1000 ms. Typical scan rates are between 10 and 1000 V/s. Removal of oxygen from the solutions studied is not required. Electrochemical conditioning of the working electrode is sufficient to insure a stable response for a period of several hours. For strongly adsorbing molecules the linear dynamic range extends over two orders of magnitude from about 10 −7 M to 10 −5 M with the relative standard deviation for replicate determinations lower than 5%. The smallest discernable signal is associated with about 0.1% surface coverage, which corresponds to the adsorption of about 10 −18 mol of analyte on a ultramicroelectrode 5 μm in radius. Keywords: adsorption, cyclic voltammetry, ultramicroelectrode, flow injection.
Split-peak phenomenon in nonlinear chromatography. 1. A theoretical model for irreversible adsorption (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSplit-peak phenomenon in nonlinear chromatography. 1. A theoretical model for irreversible adsorptionAlain. Jaulmes and Claire. Vidal-MadjarCite this: Anal. Chem. 1991, 63, 11, 1165–1174Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/ac00011a020https://doi.org/10.1021/ac00011a020research-articleACS PublicationsRequest reuse permissionsArticle Views120Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Factors affecting occurrence of gastric varioliform lesions: A case-control study (2016)

Seven risk factors and two protective factors are determined for GVLs, which were found to be associated with premalignant abnormalities.
Ballistic transport of holes and phonon replicas in lightly doped GaAs (1997)

We study the motion of nonequilibrium light holes injected into very lightly doped GaAs using a hot-hole three-terminal device. We observe directional multiple longitudinal-optical (LO) phonon emission by the holes. Using transverse magnetic field we observed scattering of light holes into heavy-hole states after the first phonon emission. An unexpected 18 meV shift of the phonon replica spectrum suggests that the Fermi level is pinned in an impurity band, in the gap, formed in the ${\mathrm{p}}^{+}$ regions. We find that the mean-free path of light holes, with energy just below the LO phonon emission threshold, is 300--360 nm. The results are compared with those obtained for electrons.
Fault diagnosis based on confidence level in networked control systems (2010)

A new method of fault diagnosis based on confidence level is presented in networked control systems with multi-step delay. Different controllers are designed, which are shown to render corresponding networked control systems asymptotically stable and mean square exponentially stable.
Practical and Enantiospecific Synthesis of LY303870, a Novel NK-1 Antagonist (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPractical and Enantiospecific Synthesis of LY303870, a Novel NK-1 AntagonistPhilip A. Hipskind, J. Jeffry Howbert, Stephen Cho, Jason S. Cronin, Stuart L. Fort, Francis O. Ginah, Guy J. Hansen, Bret E. Huff, Karen L. Lobb, and Cite this: J. Org. Chem. 1995, 60, 21, 7033–7036Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://doi.org/10.1021/jo00126a069RIGHTS & PERMISSIONSArticle Views354Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (469 KB) Get e-Alerts Get e-Alerts
Damage detection and assessment in fibre-reinforced composite structures with embedded fibre optic sensors-review (2002)

A state-of-the-art review is presented regarding the research and development of in situ fibre optic damage detection and assessment systems (FODDAS) embedded in fibre-reinforced composite structures. Representative individual fibre optic strain sensors and distributed sensor networks are briefly described. A major emphasis is placed on their capabilities for detecting damage, determining damage location and assessing the nature of damage, arising primarily from specific events such as impacts or quasi-static stress overloads. The main features of such systems as custom-built and structure-specific units with minimal human involvement are highlighted. Issues that could affect the validity of the performance of such strain sensors are discussed. Fracture and non-fracture of fibre optic sensors are identified as two fundamentally different approaches for damage detection and their primary features are discussed in relation to location determination and evaluation of the nature of damage. The major advantages and limitations of each approach are discussed. Directions and areas of potential future research in the development of related FODDAS are highlighted.
Design and Implementation of the Mobile IPTV Service Based on the IMS Intelligent Terminal (2011)

This paper introduces the IP Multimedia Subsystem (IMS) and its terminal application. It develops a software system of the IMS intelligent terminal based on Windows Mobile. The paper also introduces the development environment and the overall structure of the IMS terminal and describes the main thread. It presents the complete process of the Internet Protocol Television (IPTV) in detail through elaborating the design of the IMS registration message and IPTV services. IPTV based on the IMS terminal can be played in the experiment network. It verifies the validity and feasibility of the system design by testing.
Impact of global cerebral atrophy on clinical outcome after subarachnoid hemorrhage (2013)

Worse mRS score, NIHSS score, executive functioning, and EQ-5D scores were associated with greater brain atrophy and older age, male sex, and SIRS burden. These data suggest outcome is associated with factors that cause global brain injury independent of focal brain injury.
A TB40/E-Derived Human Cytomegalovirus Genome with an Intact US-Gene Region and a Self-Excisable BAC Cassette for Immunological Research (2017)

For immunological research on the human cytomegalovirus (HCMV), a virus that combines the broad cell tropism of clinical isolates, efficient replication in cell culture, the complete set of MHC-I modulator genes, and suitability for genetic engineering is desired. Here, we aimed to generate a genetically complete derivative of HCMV strain TB40/E as a bacterial artificial chromosome (BAC) with a self-excisable BAC cassette. The BAC cassette was inserted into the US2-US6 gene region (yielding TB40-BACKL7), relocated into the UL73/UL74 region with modifications that favor excision of the BAC cassette during replication in fibroblasts, and finally the US2-US6 region was restored, resulting in BAC clone TB40-BACKL7-SE When this BAC clone was transfected into fibroblasts at efficiencies >0.1%, replicating virus that had lost the BAC cassette appeared within 2 weeks after transfection, grew to high titers, and displayed the broad tropism of the parental virus. The degree of MHC-I down-regulation by this virus was consistent with functional restoration of US2-US6. To enable detection of infected cells by flow cytometry, an enhanced green fluorescent protein (EGFP)-expression cassette was inserted downstream of US34A, yielding the fluorescent virus RV-TB40-BACKL7-SE-EGFP.
Metastability tolerant mesochronous synchronization (2007)

In this work, a new synchronization scheme for mesochronous communication is proposed. This design has better metastability tolerance compared to state-of-the-art synchronizers. It has low latency and is only composed of standard digital components. This solution avoids the prevalent assumption, in many contemporary synchronizing techniques, of solving the metastability in half a clock cycle. The new design achieves latency as low as one clock cycle for a 500 MHz, system clock, under 0.18 micron TSMC technology. A proof of concept simulation is performed and a comprehensive design methodology is proposed.
Affinity of Fatty Acid for rRat Intestinal Fatty Acid Binding Protein:  Further Examination (1996)

The enhancement of the fluorescence quantum yield of 1,8-anilinonaphthalenesulfonic acid (ANS) upon binding to intestinal fatty acid protein (I-FABP) was exploited to devise an assay for free I-FABP. With this assay, we monitored the competition for free I-FABP between ANS and fatty acids and thereby extracted values for the dissociation constants (KFA) of fatty acids for I-FABP. We obtained these constants for the I-FABP ligands oleic acid, arachidonic acid, and palmitic acid. In addition, we measured the dependence of KFA for oleic acid upon temperature and at two pH values. From these data, we calculate the van't Hoff enthalpy of oleic acid binding. This enthalpy is compared with the enthalpies of binding obtained directly from titration calorimetry. Our experiments with the fluorescence-based assay generate values of KFAwhich disagree with older values obtained from calorimetry and other methods. Our own calorimetric data were analyzed with a view to improving the technique involved in subtraction of a “reference” dilution of the ligand into solution in the absence of the protein. By this maneuver, we obtained “corrected” titrations which could be fitted to values of KFA more in agreement with the values we determined via the fluorescence-based assay than were the older literature values. Our new values for KFA also agree substantially with values derived using a complementary assay technique, one measuring the concentration of free fatty acid, that has recently been developed by Richieri et al. [Richieri et al. (1995) J. Biol. Chem. 270, 15076−15084]. We compare the values of ΔH°, ΔS°, and ΔCp° for fatty acid binding we have obtained in this work with those we found in earlier work with ANS binding to I-FABP [Kirk et al. (1996) Biophys. J. 70, 69−83]. Our interpretation of the origin of the thermodynamic changes for ANS binding in our earlier work is here substantiated and extended to include an evaluation in physical terms of the interaction of I-FABP with fatty acids.
Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas (2009)

We showed that SP cells existed in bone sarcoma cell lines. SP cells of MFH2003 had cancer-initiating ability in vitro and in vivo. The gene profiles of SP cells could serve as candidate markers for CSCs in bone sarcomas.
Which method should be used for brain connectivity analysis? (2013)

One possible way to examine brain connectivity is to study correlations between signals recorded from different areas. The recent trends couple the signal processing based on data-driven mathematical methods with graph analysis performed on the connectivity matrix. The connectivity matrices can be evaluated by using several methods, and different toolboxes are available. The aim of the proposed platform is to create an embedded environment where it is possible to study brain connectivity through different methods and at the same time to compare the results. For this purpose different procedures are developed: from frequency and lag selection in the case of time or frequency varying analyses, to binary graph creation and binary and weighted graph comparisons. This software is realized with a high level of modularity, making it possible to integrate new analysis methods and clustering approaches.
Immersed boundary method predictions of shear stresses for different flow topologies occuring in cerebral aneurysms (2010)

A volume-penalizing immersed boundary method is presented that facilitates the computation of incompressible fluid flow in complex flow domains. We apply this method to simulate the flow in cerebral aneurysms, and focus on the accuracy with which the flow field and the corresponding shear stress field are computed. The method is applied to laminar, incompressible flow in curved cylindrical vessels and in a model aneurysm. The time-dependent shear stress distributions over the vessel walls are visualized and interpreted in terms of the flow fields that develop. We compute shear stress levels at two different Reynolds numbers, corresponding to a steady and an unsteady flow. In the latter situation strong fluctuations in the shear stress are observed, that may be connected to raised risk-levels of aneurysm rupture.
Automatic detection of the words that will become unintelligible through Japanese accented pronunciation of English (2013)

This study examines automatic detection of the words that will be unintelligible if they are spoken by Japanese speakers of English. In our previous study By using the results, in this study, we define the words that are very unintelligible through Japanese accented English pronunciation and also define the words that are rather unintelligible. Then, by using Classification And Regression Tree (CART) with linguistic features and lexical features only, we examine automatic detection of these words. After that, we introduce an additional feature derived by considering phonological and phonotactic differences between Japanese and English. This additional feature is found to be very effective and our proposed method can detect very unintelligible words and rather unintelligible words automatically with F1-scores of 65.44 and 70.45 [%], respectively.
Light Trapping for High Efficiency Heterojunction Crystalline Si Solar Cells (2011)

Light trapping plays an important role to achieve high short circuit current density (Jsc) and high efficiency for amorphous/crystalline Si heterojunction solar cells. Si heterojunction uses hydrogenated amorphous Si for emitter and back contact. This structure of solar cell posses highest open circuit voltage of 0.747 V at one sun for c-Si based solar cells. It also suggests that over 25% record-high efficiency is possible with further improvement of Jsc. Light trapping has two important tasks. The first one is to reduce the surface reflectance of light to zero for the solar spectrum that Si has a response. The second one is to increase the effective absorption length to capture all the photon. For Si heterojunction solar cell, surface texturing, anti-reflectance indium tin oxides (ITO) layer at the front and back are the key area to improve the light trapping.
Fluorescence IgG immunosensor based on a micro flow cell containing controlled pore glass as immobilisation support (2000)

Biosensor miniaturisation often requires the construction of micro volume cells using micro-machining techniques. In this work, a micro flow cell made of a transparent polymer [poly(methyl methacrylate)] developed for using with a fluorescence immunoglobulin G (IgG) immunosensor is described. The micro flow cell provides space to enclose a small amount of controlled pore glass (CPG), a transparent support that can host and covalently bind the biomolecules. The immobilisation of IgG on CPG permits the development of an optical immunosensor for the detection of fluorescein isothiocyanate (FITC)-labelled anti-IgG. In this immunosensor the excitation light is provided by an argon ion laser and guided by an optical fibre to the flow cell, where the fluorescence signal is filtered by a long-pass barrier filter (OG515) and then detected by a close positioned photodiode. This signal was found to be proportional to the amount of anti-IgG–FITC bound to the immobilised IgG during a direct immunochemical reaction. Characterisation of the CPG as an optical medium and immobilisation support was performed. CPG produces intense light scattering and good permeability to fluids, and also a typical immobilisation rate for IgG of about 90% of the initial amount of antibody. The described immunosensor shows a detection limit for anti-IgG–FITC of 6.3 nM and a sensitivity of 9.5 μV nM−1. This immunoptode developed with a micro flow cell has been shown to be a suitable system for the detection of immunoglobulins.
Revealing the Complex Nature of Bonding in the Binary High-Pressure Compound FeO2 (2021)

Extreme pressures and temperatures are known to drastically affect the chemistry of iron oxides, resulting in numerous compounds forming homologous series nFeOmFe_{2}O_{3} and the appearance of FeO_{2}. Here, based on the results of in situ single-crystal x-ray diffraction, Mössbauer spectroscopy, x-ray absorption spectroscopy, and density-functional theory+dynamical mean-field theory calculations, we demonstrate that iron in high-pressure cubic FeO_{2} and isostructural FeO_{2}H_{0.5} is ferric (Fe^{3+}), and oxygen has a formal valence less than 2. Reduction of oxygen valence from 2, common for oxides, down to 1.5 can be explained by a formation of a localized hole at oxygen sites.
Rabacfosadine for naïve canine intermediate to large cell lymphoma: Efficacy and adverse event profile across three prospective clinical trials (2020)

While current lymphoma therapies induce remission in most dogs, drug-resistant relapse is common, creating a need for novel agents. Rabacfosadine (RAB), a double prodrug of the acyclic nucleotide phosphonate 9-(2-phosphonylmethoxyethel) guanine (PMEG), preferentially targets lymphoma cells with reduced systemic toxicity compared with PMEG. Previous studies evaluating RAB administered every 21 days have suggested efficacy in both naïve and relapsed subjects; however, no large studies of RAB as a single agent have been reported in previously untreated dogs with intermediate to large cell lymphoma. The purpose of this study was to evaluate the safety and efficacy of RAB in dogs with previously untreated (excluding corticosteroids) lymphoma. Sixty-three dogs received up to five RAB treatments every 21 days (16 at 0.82 mg/kg and 47 at 1.0 mg/kg) as a 30 minutes intravenous infusion, with (n = 23) or without (n = 40) concurrent corticosteroids. Response assessment and adverse event (Ae) evaluation were performed every 21 days via Veterinary Cooperative Oncology Group (VCOG) criteria. The overall response rate was 87% (52% CR, 35% PR). The overall median progression free interval was 122 days (199 for CR, 89 for PR and 153 days for all responders). T-cell immunophenotype and corticosteroid pre-treatment were predictive of inferior outcomes on multivariate analysis. AEs were most commonly of gastrointestinal origin (hyporexia/diarrhoea) and generally resolved with supportive treatment and/or dosage adjustment. Three dogs experienced VCOG-CTCAE grade 5 delayed pulmonary fibrosis. In conclusion, RAB administered every 3 weeks is generally well tolerated and demonstrates substantial antitumour activity in dogs with previously untreated intermediate to large cell lymphoma.
The multi-position calibration of the stiffness for atomic-force microscope cantilevers based on vibration (2015)

Calibration of the stiffness of atomic force microscope (AFM) cantilevers is critical for industry and academic research. The multi-position calibration method for AFM cantilevers based on vibration is investigated. The position providing minimum uncertainty is deduced. The validity of the multi-position approach is shown via theoretical and experimental means. We applied it to the recently developed vibration method using an AFM cantilever with a normal stiffness of 0.1 N m−1. The standard deviation of the measured stiffness is 0.002 N m−1 with a mean value of 0.189 N m−1 and the relative combined uncertainty is approximately 7%, which is better than the approach using the single position at the tip of the cantilever.
Evaluation of the shielding effects on printed-circuit-board transformers using ferrite plates and copper sheets (2002)

This paper presents an effective shielding technique and a simple structure for printed-circuit-board (PCB) transformers. The performance of PCB transformers using the proposed shielding technique is evaluated using thin ferrite plates and copper sheets. Without affecting the transformer energy efficiency, the shielding method under investigation can achieve 28 dB shielding effectiveness (SE), which is much higher than the SE (about 4 dB) obtained by shielding the transformer windings with only two ferrite plates. The proposed PCB transformer structure is very simple and has high energy efficiency (>90%) for Megahertz operation.