gebhart/patrepeval huggingface dataset:
Maintenance of long‐term potentiation in hippocampal mossy fiber—CA3 pathway requires fine‐tuned MMP‐9 proteolytic activity (2013)

Mechanisms of synaptic plasticity involve proteolytic activity mediated by a complex system of proteases, including members of metalloproteinase (MMP) family. In particular, MMP-9 is critical in LTP maintenance in the Schaffer collateral-CA1 pathway and in the acquisition of hippocampus-dependent memory. Recent studies from this laboratory revealed that in the mossy fiber-CA3 (MF-CA3) projection, where LTP induction and expression are largely presynaptic, MMPs blockade disrupts LTP maintenance and that LTP induction is associated with increased MMP-9 expression. Here we used acute brain slices from MMP-9 knock-out mice and transgenic rats overexpressing MMP-9 to determine how manipulations in endogenous MMP-9 affect LTP in the MF-CA3 projection. Both types of transgenic models showed a normal basal synaptic transmission and short-term plasticity. Interestingly, the maintenance of LTP induced in slices from knock-out mice and overexpressing rats was nearly abolished. However, in the presence of active MMP-9, a gradual fEPSP autopotentiation was observed and tetanization evoked a marked LTP in knock-out mice. Additionally, in MMP-9-treated slices from wild-type mice, fEPSP autopotentiation also occurred and partially occluded LTP. This indicates that exogenous protease can restore LTP in null mice whereas in the wild-type, MMP-9 excess impairs LTP. We expected that LTP maintenance in transgenic rats could be re-established by a partial MMP blockade but non-saturating concentrations of MMP inhibitor were ineffective. In conclusion, we demonstrate that LTP maintenance in MF-CA3 pathway requires fine-tuned MMP-9 activity and raises the possibility that altered MMP-9 level might be detrimental for cognitive processes as observed in some neuropathologies.
Tissue plasminogen activator resistance is an early predictor of posttraumatic venous thromboembolism: A prospective study from the CLOTT research group (2022)

Therapeutic/Care Management; Level II.
High-Performance Superconductor (2004)

This issue of MRS Bulletin provides an overview of the current status of research and development in the area of high-temperature superconductor (HTS) wires. High-temperature oxide superconductors, discovered in the late 1980s, are moving into the second generation of their development. The first generation relied on bismuth strontium calcium copper oxide, and the second generation is based on yttrium barium copper oxide, which has the potential to be less expensive and to perform better. The potential uses of HTS wires for electric power applications include underground transmission cables, oil-free transformers, superconducting magnetic-energy storage units, fault-current limiters, high-efficiency motors, and compact generators. Wires of 10‐100 m in length can now be made, but material and processing issues must be solved before an optimized production scheme can be achieved. This issue covers a range of processing techniques using energetic beams, rolling, and laser and chemical methods to form wires with good superconducting properties.
High‐temperature resins based on aromatic amine‐terminated bisaspartimides (1983)

Abstract Various 4,4′‐bis{ N 2 ‐[4‐(4‐aminophenoxy)phenyl]aspartimido}diphenylmethane (APADM)‐type precursors were synthesized by Michael‐type reaction of an aromatic bismaleimide (1mol) with an aromatic diamine (2 mol) in an aprotic solvent. The structures of these materials were characterized by using Fourier‐transform infrared (FT‐IR), 1 H nuclear magnetic resonance (NMR) and 13 C‐NMR; their curing behaviors and thermal stabilities were evaluated by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The thermal polymerization of APADM by heating it above its melting temperature produced a tough polymer. From these preimidized precursors, graphite‐fiber laminates were prepared and their mechanical properties evaluated. To elucidate the thermal curing mechanism and the structure of the polymer, a model compound, N ‐[4‐(4′‐aminobenzyl) phenyl] aspartimidobenzene was synthesized. The gas‐chromatographic mass spectra of these compounds has suggested a mechanism for their decomposition. The structure of the polymer also was studied by using FT‐IR and 1 H‐NMR.
Molecular and Biological Properties of Human Macrophage Growth Factor, CSF-1 (1986)

CSF-1 belongs to a family of colony-stimulating factors (CSF) that regulate the production of the blood cells (Metcalf 1984). CSF-1 is a specific growth and differentiation factor for bone-marrow progenitor cells of the mononuclear phagocyte lineage and also promotes the proliferation of mature macrophages via specific receptors on the responding cells (Das et al. 1981; Das and Stanley 1982). CSF-1 also has a variety of stimulatory effects on the function of macrophages and monocytes. In this paper, we summarize the cloning of the cDNA and the genomic structure of human CSF-1, and we describe properties of the macrophage growth factor that may make it a useful drug in several clinical settings.
MoCoMapps (2012)

This video demonstrates an experiment in crowdsourcing both map-based data and also the applications that provide the maps, and also presents scenarios of use.
ChemInform Abstract: Flash Vacuum Pyrolysis of Pyrazoles (I) as an Alternative Way to Study Vinylcarbenes. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Comparing the Biomechanical Stability of Cortical Screw Trajectory Versus Standard Pedicle Screw Trajectory for Short- and Long-Segment Posterior Fixation in 3-Column Thoracic Spinal Injury (2019)

CS trajectory is a valid alternative to PS trajectory for thoracic spine fixation in 3-column spinal injuries, and long-segment fixation is superior to short-segment fixation with either.
Surface enhanced Raman spectroscopy of Aurora kinases: direct, ultrasensitive detection of autophosphorylation (2013)

Highly sensitive surface enhanced Raman spectroscopy (SERS) was used to study two of the tumorigenic aurora family kinases, Aurora A and Aurora B in sub-picomole quantities. Significantly, the proteins on conjugating to SERS-active citrate-capped silver nanoparticles retain their enzyme activity as demonstrated by kinase assays, making SERS suitable for studies of enzymatic processes. The ability to differentiate between two structurally similar homologous proteins further corroborates the sensitivity of this technique. Based on the available structural information we demonstrate here that SERS could be used for direct and ultra-sensitive detection of autophosphorylation. The overall reduction in SERS intensity and the presence of bands at 952 and ∼1076 cm−1 confirmed the phosphorylated state of Aurora A. Thus, the detection of autophosphorylation in a full length protein is demonstrated for the first time using SERS, which is critical to attain its active conformation.
Molybdate Corrosion Inhibition in Deaerated and Low-Oxygen Waters (1986)

The inhibiting effect of sodium molybdate on mild steel corrosion in deaerated and low-oxygen concentration waters at pH 9.0 and 60 C was investigated using weight loss and electrochemical test methods. Molybdate was inhibitive at a water oxygen concentration between 1 and 2.5 mg/L. In combinations with sodium nitrite, molybdate exhibited synergistic inhibition at 1 mg/L oxygen. An explanation of the observed synergism is discussed based on the electrochemical study.
Transport of fluid by lens epithelium (1999)

We report for the first time that cultured lens epithelial cell layers and rabbit lenses in vitro transport fluid. Layers of the alphaTN4 mouse cell line and bovine cell cultures were grown to confluence on permeable membrane inserts. Fluid movement across cultured layers and excised rabbit lenses was determined by volume clamp (37 degrees C). Cultured layers transported fluid from their basal to their apical sides against a pressure head of 3 cmH2O. Rates were (in microliter. h-1. cm-2) 3.3 +/- 0.3 for alphaTN4 cells (n = 27) and 4.7 +/- 1.0 for bovine layers (n = 6). Quinidine, a blocker of K+ channels, and p-chloromercuribenzenesulfonate and HgCl2, inhibitors of aquaporins, inhibited fluid transport. Rabbit lenses transported fluid from their anterior to their posterior sides against a 2.5-cmH2O pressure head at 10.3 +/- 0.62 microliter. h-1. lens-1 (n = 5) and along the same pressure head at 12.5 +/- 1.1 microliter. h-1. lens-1 (n = 6). We calculate that this flow could wash the lens extracellular space by convection about once every 2 h and therefore might contribute to lens homeostasis and transparency.
Dynamic matrix controller in wind tunnel flow field based on incomplete step response (2017)

In order to improve the quality of flow field in wind tunnel in China, The 2.4 m × 2.4 m intermittent wind tunnel control Mach number is required to achieve the accuracy of 0.001. Dynamic matric control is a great way to handle multi-variable, time delayed nonlinear control system, and there are nonlinear, time-delayed problems of Mach number control in intermittent wind tunnel. The prediction models use step response coefficients to be the parameters of the wind tunnel system, however, the time of wind tunnel test is about 90s, if the quantity of step response coefficients N is too large, it spends a long time collecting step response coefficients and we have limited time for aircraft blowing test. We need to get four different kinds of step response coefficients. So, we have to use incomplete step response coefficients as prediction model, If the number N is less than the number of the stable value of the step response, the truncation error is generated in the prediction process. In order to get a less number N and at the same time eliminate the truncation error, this paper improves the dynamic matrix control algorithm to get better results.
Aggregation of a semifluorinated n-alkane in perfluorooctane (1993)

The phase behavior of solutions of two semifluorinated n-alkanes, heptadecafluorotetracosane (F(CF2)8(CH2)16H) and pentacosafluorooctacosane (F(CF2)12(CH2)16H), in perfluorooctane and isooctane is studied. Viscosity, dynamic light-scattering, and small-angle neutron-scattering data show the presence of small, nearly spherical aggregates in heptadecafluorotetracosane/perfluorooctane solutions in the liquid phase above the critical micelle concentration. We determined the size and average aggregation number of these aggregates as a function of the fluorohydrocarbon concentration. Small-angle neutron-scattering results show that the perfluorooctane solvent penetrates appreciably into the micellar core.
A plasma initiator using a multi-winding transformer for large tokamak devices and the application to the poloidal field coil power supply system. (1994)

This paper describes a multi-winding transformer as a plasma initiator in tokamak devices and the application to the design of poloidal field coil power supply system. The scale of tokamak device has been considerably increased based on some experimentally obtained scalings of a energy confinement, because the plasma performance has been improved with the current and size parameters. Since large tokamaks require the hybrid functional poloidal field coil system, the each coil power supplies must prepare the high voltage generation circuit for the plasma breakdown, and it causes increase in the number of current interrupters, disconnectors and the resisters. Therefore, the plasma position and shape control tend to be difficult especially in the start-up phase of the discharge. The plasma initiator proposed in this paper makes the plasma initiation circuit to be simple by unification of the high voltage generation circuit. It has similar ampere-turn and permeance distribution with the tokamak device and produces the magnetic field necessary for plasma breakdown. An application to FER tokamak proposed by JAERI is also presented.
Reference Values for Dynamic Responses to Incremental Cycle Ergometry in Males and Females Aged 20 to 80 (2001)

Interpretation of incremental cardiopulmonary exercise tests (CPET) might be enhanced by considering the simultaneous rates of change of certain key variables, e.g., Delta oxygen uptake/Delta work rate (Delta VO(2)/Delta WR), Delta heart rate/Delta VO(2) (Delta HR/Delta VO(2)), Delta ventilation/Delta carbon dioxide production (Delta VE/Delta VCO(2)), and the linearized Delta tidal volume/Delta VE (Delta VT/Delta lnVE) relationships. However, there are no published age- and sex-dependent reference values for these relationships that were appropriately obtained in randomly selected subjects. We therefore prospectively evaluated 120 sedentary individuals (60 male, 60 female, age 20 to 80 yr) who were randomly selected from more than 8,000 subjects, and submitted to standard ramp-incremental CPET on an electronically braked cycle ergometer. We found that sex and age significantly influenced several of the dynamic relationships, in addition to anthropometric attributes (p < 0.05). A comprehensive set of linear prediction equations is provided; the limits of normality (at the 95% confidence level) differed substantially from previous recommendations based on single discrete values. These data therefore provide a frame of reference for assessing the normalcy of the response profiles of four standard indices of metabolic, cardiovascular, and ventilatory function during rapidly incremental cycle ergometry in sedentary males and females up to 80 yr of age.
Dynamics of nonequilibrium thermal entanglement for simple spin chains (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation I. Sinayskiy, N. Pumulo, F. Petruccione; Dynamics of nonequilibrium thermal entanglement for simple spin chains. AIP Conference Proceedings 14 October 2011; 1363 (1): 287–290. https://doi.org/10.1063/1.3630198 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Biofunctional Peptide-Modified Extracellular Vesicles Enable Effective Intracellular Delivery via the Induction of Macropinocytosis (2021)

We previously reported that macropinocytosis (accompanied by actin reorganization, ruffling of the plasma membrane, and engulfment of large volumes of extracellular fluid) is an important process for the cellular uptake of extracellular vesicles, exosomes. Accordingly, we developed techniques to induce macropinocytosis by the modification of biofunctional peptides on exosomal membranes, thereby enhancing their cellular uptake. Arginine-rich cell-penetrating peptides have been shown to induce macropinocytosis via proteoglycans; accordingly, we developed peptide-modified exosomes that could actively induce macropinocytotic uptake by cells. In addition, the activation of EGFR induces macropinocytosis; based on this knowledge, we developed artificial leucine-zipper peptide (K4)-modified exosomes. These exosomes can recognize E3 sequence-fused EGFR (E3-EGFR), leading to the clustering and activation of E3-EGFR by coiled-coil formation (E3/K4), which induces cellular exosome uptake by macropinocytosis. In addition, modification of pH-sensitive fusogenic peptides (e.g., GALA) also enhances the cytosolic release of exosomal contents. These experimental techniques and findings using biofunctional peptides have contributed to the development of exosome-based intracellular delivery systems.
Performance Characteristics of Sensor Part in Extensometer Using Strain Gauge (2019)

스트레인게이지를 이용한 연신율계의 측정정밀도를 개선하기 위해서는 센서의 재질과 형상에 따라 시료의 변형에 대한 센서부 변형의 비선형성, 반복성이 중요하다. 이를 위해 이론과 유한요소법을 사용하여 시료의 변형에 따라 센서의 측정성능을 예측할 수 있는 이론식을 유도하였다. 측정실험에 의하여 연신율계 내부의 수감부에 대한 이론에 근거하여 예측한 이론 출력값과 실험값을 비교하였고 결과의 유사성을 확인하였다. 이를 위해 자체 제작한 1/1000 ㎜급 다이얼게이지가 부착된 연신율계 교정기를 사용하였다.
Unmanned aerial vehicle based forest fire monitoring and detection using image processing technique (2016)

Early forest fire alarm systems are critical in making prompt response in the event of unexpected hazards. Cost-effective cameras, improvements in memory, and enhanced computation power have all enabled the design and real-time application of fire detecting algorithms using light and small-size embedded surveillance systems. This is vital in situations where the performance of traditional forest fire monitoring and detection techniques are unsatisfactory. This paper presents a forest fire monitoring and detection method with visual sensors onboard unmanned aerial vehicle (UAV). Both color and motion features of fire are adopted for the design of the studied forest fire detection strategies. This is for the purpose of improving fire detection performance, while reducing false alarm rates. Indoor experiments are conducted to demonstrate the effectiveness of the studied forest fire detection methodologies.
Topic-bridged PLSA for cross-domain text classification (2008)

In many Web applications, such as blog classification and new-sgroup classification, labeled data are in short supply. It often happens that obtaining labeled data in a new domain is expensive and time consuming, while there may be plenty of labeled data in a related but different domain. Traditional text classification ap-proaches are not able to cope well with learning across different domains. In this paper, we propose a novel cross-domain text classification algorithm which extends the traditional probabilistic latent semantic analysis (PLSA) algorithm to integrate labeled and unlabeled data, which come from different but related domains, into a unified probabilistic model. We call this new model Topic-bridged PLSA, or TPLSA. By exploiting the common topics between two domains, we transfer knowledge across different domains through a topic-bridge to help the text classification in the target domain. A unique advantage of our method is its ability to maximally mine knowledge that can be transferred between domains, resulting in superior performance when compared to other state-of-the-art text classification approaches. Experimental eval-uation on different kinds of datasets shows that our proposed algorithm can improve the performance of cross-domain text classification significantly.
Grid-Tied Inverter with Simplified Virtual Synchronous Compensator for Grid Services and Grid Support (2019)

This paper proposes a grid-connected inverter whose control is enhanced with a Simplified Virtual Synchronous Compensator (S-VSC) working in parallel with the traditional inverter current control loops. The goal of the integration of this model into the inverter control scheme is to provide grid services, such as virtual inertia behavior, current harmonic compensation, as well as reactive grid support during faults. The S-VSC is only in charge of providing the aforementioned services, working therefore always at a low power level. On the other hand, the main power references are sent directly to the inverter control loops. This way, a more stable and damped operation of the inverter is obtained. The proposed structure has been implemented on a 15 kVA grid-connected inverter for experimental validation.
Hacia una política de investigación en la Universidad Pontificia Bolivariana (1985)

La condicion de subdesarrollo que padecen los paises del tercer mundo solo podra superarse con un sinnumero de avances complejos de diversa categoria. Pero, en esta gama de perspectivas se encuentra presente de manera clara, la necesidad imperiosa de realizar mas y mejores investigaciones en todos los campos de la ciencia y de la tecnologia. Pensar que todo esta inventado en los paises desarrollados, es una posicion excesivamente comoda que lleva necesariamente al mantenimiento del atraso vigente. (…)
Stimulating Erythropoiesis: Future Perspectives (2008)

The introduction of recombinant human erythropoietin (rHuEpo) nearly 20 years ago has revolutionised the management of patients with CKD, providing the opportunity for safe long-term anaemia correction without the attendant risks identified with blood products. Based on our expanding knowledge in this area, there are many exciting and innovative new approaches to anaemia correction that stand on, or are close to, the threshold of yielding products ready for clinical use. Recently, an Epo-related molecule called continuous Epo receptor activator has been licensed in Europe, and other molecules are in various processes of development, including Epo mimetic peptide. The search goes on for orally active antianaemic therapies, and several strategies are being investigated. Furthermore, it is now clear that in addition to the anaemia-correction properties of erythropoiesis-stimulating agents, there is the potential for cytoprotection by prevention of cellular apoptosis. This effect could be used in the prevention of ischaemia-reperfusion injury as well as other conditions associated with acute kidney injury and other disease processes. The aim of this article is to discuss these possible future strategies, focusing in particular on those with a reasonable likelihood of a pharmaceutical product that is likely to be used clinically.
FAILURE OF ADRENERGIC α AND β RECEPTOR BLOCKADE TO ELEVATE THE TSH AND PROLACTIN RESPONSE TO TRH IN HYPERTHYROIDISM (1975)

SUMMARY The effects of adrenergic α and β receptor blockade on the thyrotrophin and prolactin responses to TRH were studied in groups of hyperthyroid patients who received either oral propranolol and phenoxybenzamine or intravenous propranolol and rogitine. The flat TSH and prolactin responses to TRH in the untreated hyperthyroid patients were not altered by oral or intravenous adrenergic α and β receptor blockade suggesting that catecholamines do not play a major role in the feedback suppression of TSH and prolactin in hyperthyroidism.
<title>Characterization of chirped phase masks for UV applications by writing and investigation of fiber Bragg gratings</title> (1997)

We describe the characterization of chirped phase masks made by electron beam writing and reactive ion etching in pure silica. The phase masks are designed to be used as diffractive optical elements in the process of manufacturing of fiber Bragg gratings (FBG). With the technologies available at our institutes grating structures with periods less than 200 nm can be realized in fused silica. Phase masks for writing ideally chirped FBG would require grating structures with continuously changing period. However because of the limited position accuracy of any e-beam writer, it is not possible to generate the desired continuous variation of the grating period. There appear discrete displacement steps with deviations of some nanometers. We obtain some information about the parameters of the phase mask from the properties of written fiber gratings. A sequence of short fiber gratings is written in order to characterize the phase mask. We use a slit to expose a definite small part of the phase mask pattern during the writing process of each short fiber grating. The center wavelength of each fiber grating is analyzed.