gebhart/patrepeval huggingface dataset:
Neuronal-activity regulated gene expression: emphasis on BDNF (2015)

SpringerPlus 2015, 4(Suppl 1):L1 MicroRNAs (miRNAs) are short, 22-25 nucleotide long transcripts that may suppress entire signaling pathways by interacting with the 3'-untranslated region (3'-UTR) of coding mRNA targets, interrupting translation and inducing degradation of these targets. The long 3'-UTRs of brain transcripts compared to other tissues predict important roles for brain miRNAs. Supporting this notion, we found that brain miRNAs co-evolved with their target transcripts, that non-coding pseudogenes with miRNA recognition elements compete with brain coding mRNAs on their miRNA interactions, and that Single Nucleotide Polymorphisms (SNPs) on such pseudogenes are enriched in mental diseases including autism and schizophrenia, but not Alzheimer's disease (AD). Focusing on evolutionarily conserved and primate-specifi c miRNA controllers of cholinergic signaling ('CholinomiRs'), we fi nd modifi ed CholinomiR levels in the brain and/or nucleated blood cells of patients with AD and Parkinson's disease, with treatment-related diff erences in their levels and prominent impact on the cognitive and anti-infl ammatory consequences of cholinergic signals. Examples include the acetylcholinesterase (AChE)-targeted evolutionarily conserved miR-132, whose levels decline drastically in the AD brain. Furthermore, we found that interruption of AChE mRNA's interaction with the primatespecifi c CholinomiR-608 in carriers of a SNP in the AChE's miR-608 binding site induces domino-like eff ects that reduce the levels of many other miR-608 targets. Young, healthy carriers of this SNP express 40% higher brain AChE activity than others, potentially aff ecting the responsiveness to AD's anti-AChE therapeutics, and show elevated trait anxiety, infl ammation and hypertension. Non-coding regions aff ecting miRNA-target interactions in neurodegenerative brains thus merit special attention.
High-throughput glycoanalytical technology for systems glycobiology (2010)

The development of glycoanalytical HPLC-based high-throughput technology has greatly enhanced the study of glycobiology, facilitating the discovery of disease-related solutions and providing an informative view of glycosylation and its relationship with other biological disciplines in a systems biology approach.
Three Dimensional Positive Contrast Susceptibility Fast Spin Echo MR Imaging with Variable Excitation Pulses and PD Algorithm (2019)

A susceptibility-based positive contrast MR technique is applied to image the MR compatible metallic devices by solving a regularized ℓ1 minimization problem. However, the previous SE/FSE sequence is used for the data acquisition which can result in high SAR and low sampling efficiency in 3D imaging. Therefore, a 3D single slab 3D FSE sequence with slab selective and variable excitation pulse is proposed to implement 3D positive contrast MR imaging for low SAR and acquiring high-resolution 3D images within a shorter timeframe. Furthermore, in order to achieve faster reconstruction and better imaging quality of the 3D positive contrast MRI, the primal-dual iteration algorithm is also used to solve the regularized ℓ1 minimization problem. The visualization of the positive contrast and convergence behaviour of the proposed reconstruction framework base on the first-order PD algorithm were tested and validated on phantom experiments, compared with the previous nonlinear conjugate gradient (NLCG), fast iterative soft thresholding (FISTA) and alternating direction method of multipliers (ADMM) algorithms.
Method for Non-intrusive Electric Current Estimation with Concentrated Magnetic Field (2019)

Contactless current monitoring can play a vital role in electric power distribution side for applications such as power theft control. Operating current can be monitored by contactless magnetic field sensors around the lines. Magnetic flux concentrators (MFCs) are placed to concentrate the magnetic field generated by the current carrying conductor and amplify the magnetic field signals to the magnetic sensors in close vicinity. In this study, three sensors and three MFCs are placed to measure the magnetic field produced by three-phase HV side of the distribution system. Sensors are placed at a distance of 1.2 m from the conductors outside the induction zone. But magnetic fields are weak at this distance. If there is a small change in current through conductors, the resultant magnetic field will also be changed small and at a distance where magnetic fields are already weak, a small change in a magnetic field is difficult for the sensors to be detected. To amplify the weak magnetic field Rectangular shaped Mu metal material base MFCs are designed while the concentration effect can vary by changing the length of MFCs.
[Synthesis and antiinflammatory activity of various 1,4-benzothiazine derivatives]. (1985)

A new series of dihydro-4H-1,4-benzothiazine derivatives was prepared. These compounds were obtained by reductive N-alkylation reaction with sodium borohydride in acetic acid of the corresponding 4H-1,4-benzothiazine. Some of the latter compounds were synthesized by a new synthetic method employing 2-aminobenzenethiol and alkynes as starting material. Preliminary pharmacological data on the antiinflammatory activity of these compounds by using carrageenin paw edema assay are reported.
The metabolic syndrome and its components in pediatric survivors of allogeneic hematopoietic stem cell transplantation (2016)

Metabolic syndrome (MetS) is a known complication after hematopoietic stem cell transplantations (HSCT) that contributes to long-term morbidity. We assessed the prevalence of components of the MetS in pediatric survivors of allogeneic HSCT and identified associated risk factors. Thirty-eight patients, median age at HSCT, 8.5 years, were evaluated at a median of 3.9 years post-HSCT. Overweight or obesity was seen in 23.7% of the patients, 15.8% had hypertension, 15.8% had hypertriglyceridemia, and 13% had low high-density lipoprotein cholesterol levels according to age and gender. Four (10.5%) met the criteria of MetS; all were transplanted for malignant disease. Twelve patients (31.6%) had at least one component of the MetS. The 5-year probability of developing components of the MetS revealed that patients with BMI-Z score ≥0 at HSCT were significantly at higher risk than those with lower BMI-Z. Patients who developed components of the MetS had higher levels of insulin, homeostasis model assessment, uric acid, leptin, and lower adiponectin levels. Multivariable regression analysis revealed that BMI-Z-score >1.036 at time of evaluation was associated with 4.3-fold increased risk (P=.050) and adiponectin levels ≤6 μg/mL were associated with 6.7-fold increased risk of develop components of the MetS (P=.007). Overweight and obesity and adiponectin levels may be useful as markers in HSCT survivors.
Short-tube refrigerant flow restrictors (1982)

Five short-tube refrigerant expansion devices, with L/D ratios from 7.5 to 11.9, were tested on a three-ton split-system heat pump. The test results show that first-stage choking has occurred at the liquid subcooling temperature of 22.2 C/sup 0/ (40.0 F/sup 0/). However, there is no indication that second-stage choking has ever occurred.
Topical DNA Vaccination with DNA/Lipid Based Complex (2005)

Topical DNA vaccines have been shown to elicit both broad humoral and cellular immune response in vivo. The skin is an attractive site for the delivery DNA antigens for DNA vaccination. However, due to skin's barrier properties, the penetration of DNA and the applications of topical vaccination are limited. To improve permeability of stratum corneum and the potency of topical DNA vaccines, efficient delivery systems are needed. Topical vaccination has been achieved using topical application of naked DNA with or without tape stripping and DNA/lipid based complex such as liposomes, niosomes, Transfersomes, or microemulsion. All methods resulted in significant enhancement in humoral and cellular immune response over naked DNA alone. To develop more cost-effective and needle free vaccines, skin targeted immunizations are required. This overview focuses on the comparison of the potency of topical DNA vaccine between naked DNA and DNA-lipid based complex.
A Platinum Acetylide Polymer with Sterically Demanding Substituents:  Effect of Aggregation on the Triplet Excited State (2005)

The effect of interchain interaction on the triplet excited state is explored in two Pt-acetylide polymers of the type [-trans-Pt(PBu(3))(2)-C triple bond C-Ar-C triple bond C-](n), where Ar is either 1,4-phenylene or is based on the pentiptycene unit (polymers 2 and 3, respectively). To explore the effect of interchain interaction in Pt-acetylide materials, the optical properties of parent polymer 2 are compared with those of polymer 3 in which interchain interaction is precluded by the sterically bulky pentiptycene moiety. Insight into the effect of the pentiptycene unit on packing in the solid state comes from the X-ray structure of monomer 1b, Ph-C triple bond C-[trans-Pt(PBu(3))(2)]-C triple bond C-Ar-C triple bond C-[trans-Pt(PBu(3))(2)]-C triple bond C-Ph. Spectroscopic studies indicate that weak phosphorescence emission from an interchain aggregate is observed from parent polymer 2, both in solution and in the solid state. By contrast, the photophysics of 3 is dominated by the intrachain triplet exciton. Interestingly, the phosphorescence emission of polymer 3 in the solid state is nearly superimposable with that of a single crystal of monomer 1b, suggesting that the solid polymer experiences an environment that is similar to that of the monomer in the crystal.
Guía de Práctica Clínica de la enfermedad diarreica aguda en niños menores de 5 años. Diagnóstico y tratamiento1 (2015)

Como parte del proyecto nacional de Guías de Práctica Clínica (GPC) del Ministerio de Salud, y bajo la coordinación administrativa y financiera del Departamento Administrativo de Ciencia, Tecnología e Innovación (Colciencias), el Grupo desarrollador elaboró una GPC basada en evidencia de novo con base en la más reciente literatura, luego de evaluar la calidad de la evidencia, analizar sus características y formular las mejores recomendaciones para el contexto colombiano. Se utilizó la metodología GRADE, para evaluar los riesgos de sesgos según desenlaces priorizados, y para desarrollar dichas recomendaciones, para dar respuesta a las preguntas prestablecidas y discutidas con el ente financiador. Los miembros del grupo conformaban un multidisciplinario panel, de varias áreas implicadas en la diarrea en niños, y se contó con participación de representante de pacientes y en inclusión de valores y preferencias de madres y padres. En este resumen se presentan las recomendaciones para el diagnóstico y el tratamiento del niño con diarrea en Colombia. As part of the Ministry of Health national Clinical Practice Guidelines (CPG) project, under the administrative and financial coordination of the of the Administrative Department of Science, Technology and Innovation (Colciencias), the Development Group has prepared a CPG based on the evidence gathered in the most recent literature. The quality of the evidence was then evaluated, along with an analysis of its characteristics, in order to improve the recommendations for the Colombian context. GRADE methodology was used to evaluate the risks and biases according to the prioritised outcomes and to develop these recommendations in order to provide the answers to the questions that were pre-established and discussed with the funding body. The members of the group were professionals from all areas involved in diarrhoea in children. It also included patient representatives also took part, and values and preferences of the parents were taken into account. A summary is presented on the recommendations for the diagnosis and treatment of children with diarrhoea in Colombia.
Supplementary Table 1 from Cigarette Experimentation in Mexican Origin Youth: Psychosocial and Genetic Determinants (2023)

&lt;p&gt;XLS - 104K&lt;/p&gt;
Optimal Design for a Portable NMR- and MRI-Based Multiphase Flow Meter (2018)

In this paper, an optimal design for nuclear magnetic resonance and magnetic resonance imaging based multiphase flow meter is presented. The overall apparatus consists of an electromagnetic coil surrounded by 12 rings of Halbach arrays of 12 magnets each. Both the coil and the magnets arrays were simultaneously and optimally designed using a three-dimensional (3-D) finite-element method (FEM) package and particle swarm optimization algorithm. The aim of the design is to uniformly prepolarize the hydrogen spins of the atoms composing the flowing fluid, with a predefined static magnetic field, before they enter into the measurement area within which they are homogenously polarized with a perpendicular ac magnetic field. Cheap and lightweight hardware are the other two design parameters of the design. Results of extensive 3-D simulations of the design indicate that an optimized and homogenous static magnetic field distribution could be achieved within an area of 40 mm diameter and 606 mm length. In addition, using a multiturn coil of 6 cm diameter and 2000 turns, an ac magnetic field of 13 mT amplitude and 112 ppm homogeneity could be achieved, which is enough to handle fluids flowing at speed of up to 2 m/s. Experimental validation, which was done using newly constructed two Halbach arrays of cuboid and trapezoid magnet elements, respectively, indicates a good match with FEM simulations.
Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock (2019)

Upon intravenous injection of tumour necrosis factor (TNF) in mice, a systemic inflammatory response syndrome (SIRS) is initiated, characterized by an acute cytokine storm and induction of vascular hyperpermeability. Connexin43 hemichannels have been implicated in various pathological conditions, e.g. ischemia and inflammation, and can lead to detrimental cellular outcomes. Here, we explored whether targeting connexin43 hemichannels could alleviate TNF-induced endothelial barrier dysfunction and lethality in SIRS. Therefore, we verified whether administration of connexin43-targeting-peptides affected survival, body temperature and vascular permeability in vivo. In vitro, TNF-effects on connexin43 hemichannel function were investigated by single-channel studies and Ca<sup>2+</sup>-imaging. Blocking connexin43 hemichannels with TAT-Gap19 protected mice against TNF-induced mortality, hypothermia and vascular leakage, while enhancing connexin43 hemichannel function with TAT-CT9 provoked opposite sensitizing effects. In vitro patch-clamp studies revealed that TNF acutely activated connexin43 hemichannel opening in endothelial cells, which was promoted by CT9, and inhibited by Gap19 and intracellular Ca<sup>2+</sup>-buffering. In vivo experiments aimed at buffering intracellular Ca<sup>2+</sup>, and pharmacologically targeting Ca<sup>2+</sup>/calmodulin-dependent protein kinase-II, a known modulator of endothelial barrier integrity, demonstrated their involvement in permeability alterations. Our results demonstrate significant benefits of inhibiting connexin43 hemichannels to counteract TNF-induced SIRS-associated vascular permeability and lethality.
Endovascular Treatment of an Internal Iliac Artery Aneurysm Using a Nitinol Vascular Occlusion Plug (2005)

This case illustrates the technical feasibility and successful short-term follow-up of a novel embolization approach to IIA aneurysms in patients with an aortofemoral graft.
Design and Synthesis of Tridentate Facially Chelating Ligands of the [2.n.1]-(2,6)-Pyridinophane Family (2003)

Syntheses are reported for tripyridine macrocycles 2 and 3 and some of their alkyl derivatives. The macrocycles are designed to stabilize to various extents coordinated d(8) metal precursors and d(6) alkane oxidative addition products (Pt(IV)), therefore allowing favorable kinetics and thermodynamics of (e.g., Pt(II)) the cleavage of substrate H-C(sp(3)) bonds. Both the Chichibabin protocol and oxidative coupling of carbanions by copper(I) iodide were used for the macrocyclization step. Crystal structures of singly and doubly protonated 2 establish atom connectivity in the macrocycle, and reveal structural features which are obscured in solution NMR by rapid proton migration.
Thermal Analysis for the Protrusion of Magnetic Head (2003)

The thermal protrusion of a magnetic head was investigated through, first a high-resolution measurement of temperature distribution over the air bearing surface (ABS) and head coil and, second, a numerical calculation of the head protrusion. It was found that the temperature on the ABS results in a “butterfly”-shaped distribution. It was also found that an eddy current induced by high frequency write-current significantly increases the temperature of read/write elements. Moreover, the point of maximum temperature changed from the head core to the write gap when the applied current was switched from DC to AC. It was also found that a write-current induced head protrusion caused more deformation of the alumina over coat in the horizontal direction and that an ambient-temperature-induced head protrusion caused more deformation around the read-write elements. Furthermore, it is clarified that film materials with higher elastic modulus, lower expansion rate, and higher thermal conductivity reduce the head thermal protrusion. Finally, to reduce write-current-induced head protrusion, a novel thermally improved head structure is proposed.
Unique Role of Refractory Ta Alloying in Enhancing the Figure of Merit of NbFeSb Thermoelectric Materials (2017)

Abstract NbFeSb‐based half‐Heusler alloys have been recently identified as promising high‐temperature thermoelectric materials with a figure of merit zT &gt; 1, but their thermal conductivity is still relatively high. Alloying Ta at the Nb site would be highly desirable because the large mass fluctuation between them could effectively scatter phonons and reduce the lattice thermal conductivity. However, practically it is a great challenge due to the high melting point of refractory Ta. Here, the successful synthesis of Ta‐alloyed (Nb 1− x Ta x ) 0.8 Ti 0.2 FeSb ( x = 0 – 0.4) solid solutions with significantly reduced thermal conductivity by levitation melting is reported. Because of the similar atomic sizes and chemistry of Nb and Ta, the solid solutions exhibit almost unaltered electrical properties. As a result, an overall zT enhancement from 300 to 1200 K is realized in the single‐phase Ta‐alloyed solid solutions, and the compounds with x = 0.36 and 0.4 reach a maximum zT of 1.6 at 1200 K. This work also highlights that the isoelectronic substitution by atoms with similar size and chemical nature but large mass difference should reduce the lattice thermal conductivity but maintain good electrical properties in thermoelectric materials, which can be a guide for optimizing the figure of merit by alloying.
Throughput in the ARPANET - Protocols and measurement (1977)

The speed at which large files can travel across a computer network is an important performance measure of that network. In this paper we examine the achievable sustained throughput in the ARPANET. Our point of departure is to describe the procedures used for controlling the flow of long messages (multipacket messages) and to identify the limitations that these procedures place on the throughput. We then present the quantitative results of experiments which measured the maximum throughput as a function of topological distance in the ARPANET. We observed a throughput of approximately 38 kbit/s at short distances. This throughput falls off at longer distances in a fashion which depends upon which particular version of the flow control procedure is in use; for example, at a distance of 9 hops, an October 1974 measurement gave 30 kbit/s, whereas a May 1975 experiment gave 27 kbit/s. The two different flow control procedures for these experiments are described, and the sources of throughput degradation at longer distances are identified, a major cause being due to a poor movement of critical limiting resources around in the network (this we call phasing). We conclude that flow control is a tricky business, but in spite of this, the ARPANET throughput is respectably high.
Biodegradation of Poly(Lactic Acid) Biocomposites under Controlled Composting Conditions and Freshwater Biotope (2021)

The influence of additives such as natural-based plasticiser acetyl tributyl citrate (ATBC), CaCO<sub>3</sub> and lignin-coated cellulose nanocrystals (L-CNC) on the biodegradation of polylactic acid (PLA) biocomposites was studied by monitoring microbial metabolic activity through respirometry. Ternary biocomposites and control samples were processed by a twin-screw extruder equipped with a flat film die. Commonly available compost was used for the determination of the ultimate aerobic biodegradability of PLA biocomposites under controlled composting conditions (ISO 14855-1). In addition, the hydro-degradability of prepared films in a freshwater biotope was analysed. To determine the efficiency of hydro-degradation, qualitative analyses (SEM, DSC, TGA and FTIR) were conducted. The results showed obvious differences in the degradation rate of PLA biocomposites. The application of ATBC at 10 wt.% loading increased the biodegradation rate of PLA. The addition of 10 wt.% of CaCO<sub>3</sub> into the plasticised PLA matrix ensured an even higher degradation rate at aerobic thermophilic composting conditions. In such samples (PLA/ATBC/CaCO<sub>3</sub>), 94% biodegradation in 60 days was observed. In contrast, neat PLA exposed to the same conditions achieved only 16% biodegradation. Slightly inhibited microorganism activity was also observed for ternary PLA biocomposites containing L-CNC (1 wt.% loading). The results of qualitative analyses of degradation in a freshwater biotope confirmed increased biodegradation potential of ternary biocomposites containing both CaCO<sub>3</sub> and ATBC. Significant differences in the chemical and structural compositions of PLA biocomposites were found in the evaluated period of three months.
Space, time, seeing and hearing: cortical mechanisms of sensing (2011)

Item consists of a digitized copy of a video recording of a Vancouver Institute lecture given by Max Cynader on November 10, 1990. Original video recording available in the University Archives (UBC VT 215).
The heritability of coronal and sagittal phenotype in idiopathic scoliosis: a report of 12 monozygotic twin pairs (2020)

Analysis of biplanar curve characteristics in monozygotic twins showed that all twin pairs were affected by idiopathic scoliosis. However, only 33% of the pairs had similar coronal and sagittal spinal phenotypes. Based on this limited dataset, the hypothesis can be formulated that besides genetic pre-disposition, the individual (inherited) sagittal profile plays a role in the development of different coronal curve type.