gebhart/patrepeval huggingface dataset:
ANALYSIS OF DYNAMIC MEASUREMENTS: NEW CHALLENGES REQUIRE NEW SOLUTIONS (2009)

Abstract − A dynamic measurement can be defined as a measurement where the physical quantity being measured varies with time and where this variation may have a significant effect on the measurement result and the associated uncertainty. New dynamic measurement challenges are arising in a number of metrology areas that have traditionally required only steady state or static characterisation of sensor performance. These challenges may require development of new measurement and calibration methods, as well as new methods for correcting sensor outputs and for the evaluation of uncertainties. This paper reviews these developments with a particular emphasis on the role and relevance of the Guide to the expression of uncertainty in measurement (GUM) [1] and GUM Supplement 1 (GUM S1) [2].
Simple Carrier-Based PWM Technique for a Three-to-Nine-Phase Direct AC–AC Converter (2011)

Multiphase (more than three phases) power electronic converters are required mainly for feeding variable-speed multiphase drive systems. This paper presents one such solution by using a direct ac–ac converter that can be used to supply a nine-phase drive system. The input is a fixed-voltage and fixedfrequency three-phase input, and the output is a variable-voltage and variable-frequency nine-phase output. A simple pulsewidthmodulation technique is developed for the proposed ac–ac converter named as a nonsquare three-to-nine-phase matrixconverter configuration. The developed modulation technique is based on the comparison of a high-frequency carrier signal with the duty ratios. Although the carrier-based scheme is widely employed for the control of back-to-back converters, it has recently been used for controlling a three-to-three-phase matrix converter. This concept is extended in this paper for controlling a threeto-nine-phase matrix converter. With the two techniques that are proposed, one outputs 0.75 of the input magnitude and the other outputs reach 0.762 of the input. This is the maximum value of the output voltage in the linear modulation range that can be achieved in this configuration of the matrix converter. The viability of the proposed control techniques is proved analytically through simulation and an experimental approach.
Fluoride‐Catalyzed Siloxane Exchange as a Robust Dynamic Chemistry for High‐Performance Vitrimers (2023)

Sustainable development of new technologies requires materials having advanced physical and chemical properties while maintaining reprocessability and recyclability. Vitrimers are designed for this purpose; however, their dynamic covalent chemistries often have drawbacks or are limited to specialized polymers. Here, fluoride-catalyzed siloxane exchange is reported as an exceptionally robust chemistry for scalable production of high-performance vitrimers through industrial processing of commodity polymers such as poly(methyl methacrylate), polyethylene, and polypropylene. The vitrimers show improved resistance to creep, heat, oxidation, and hydrolysis, while maintaining excellent melt flow for processing and recycling. Furthermore, the siloxane exchange between different vitrimers during mechanical blending results in self-compatibilized blends without any compatibilizers. This offers a general, scalable method for producing sustainable high-performance vitrimers and a new strategy for recycling mixed plastic wastes.
Abstract LB-356: Micelle-encapsulated thiostrepton: an effective nanomedicine for inhibiting tumor growth (2012)

Abstract The thiazole antiobiotic, thiostrepton, has been found to suppress the expression of FOXM1, the oncogenic forkhead transcription factor overexpressed in cancer cells. Thiostrepton has also been shown to induce cell death in cancer cells through a proteasome inhibitory mechanism. As thiostrepton is highly hydrophobic, encapsulation into nano-sized delivery vehicles not only aides its solubilization but also improves its targeting for tumors in vivo. This is achieved by encapsulating thiostrepton into the interior of an amphiphilic micelle, composed from an assembly of lipid-PEG (polyethylene glycol) conjugates. In this study, we examined the anti-tumor effects of micelle-thiostrepton in both subcutaneous xenograft models (HepG2 liver cancer, Capan-2 pancreatic cancer and MDA-MB-231 breast cancer) and endogenous liver tumor models (DEN/PB-induced adenocarcinomas). In the case of the xenograft tumor-bearing mice, biodistribution studies showed micelle-thiostrepton to accumulate into both the liver (30% of injected dose) and the xenograft tumors (60% of injected dose) from 4 hours post-administration. In the endogenous liver cancer models, micelle-thiostrepton accumulated into the liver only, allowing a high concentration of tumor-associated thiostrepton drug. Continuous administration of micelle-thiostrepton at doses of 40mg/kg, 3 times a week for 30 days retarded the growth rate of all subcutaneous tumors and reduced the occurrence of adenocarinomas in endogenous liver cancer models. Immunoblotting and immunohistochemical staining revealed that treatment with micelle-thiostrepton inhibited the expression of the oncogenic transcription factor FOXM1 in tumors, a reduction of which generally coincides with suppressed cell proliferation and increased cell death. Furthermore, it was found that the reduced tumor growth rate of thiostrepton-treated tumors was indeed related to increased apoptosis, as indicated by the elevated expression of cleaved caspase-3 in such tumors samples. Our data suggest that the thiazole antibiotic/proteasome inhibitor thiostrepton, when formulated into nanoparticles, may be highly suited as a nanomedicine for treating cancer, particularly that of liver cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-356. doi:1538-7445.AM2012-LB-356
Novel realisation of a broadband high-efficiency continuous class-F power amplifier (2011)

The 6th European Microwave Integrated Circuits (EuMIC 2011), Manchester, United Kingdom, 10-11 October 2011
Self-Renewal of Multipotent Long-Term Repopulating Hematopoietic Stem Cells Is Negatively Regulated by FAS and Tumor Necrosis Factor Receptor Activation (2001)

Multipotent self-renewing hematopoietic stem cells (HSCs) are responsible for reconstitution of all blood cell lineages. Whereas growth stimulatory cytokines have been demonstrated to promote HSC self-renewal, the potential role of negative regulators remains elusive. Receptors for tumor necrosis factor (TNF) and Fas ligand have been implicated as regulators of steady-state hematopoiesis, and if overexpressed mediate bone marrow failure. However, it has been proposed that hematopoietic progenitors rather than stem cells might be targeted by Fas activation. Here, murine Lin(-)Sca1(+)c-kit(+) stem cells revealed little or no constitutive expression of Fas and failed to respond to an agonistic anti-Fas antibody. However, if induced to undergo self-renewal in the presence of TNF-alpha, the entire short and long-term repopulating HSC pool acquired Fas expression at high levels and concomitant activation of Fas suppressed in vitro growth of Lin(-)Sca1(+)c-kit(+) cells cultured at the single cell level. Moreover, Lin(-)Sca1(+)c-kit(+) stem cells undergoing self-renewal divisions in vitro were severely and irreversibly compromised in their short- and long-term multilineage reconstituting ability if activated by TNF-alpha or through Fas, providing the first evidence for negative regulators of HSC self-renewal.
Activation of Sterol-response Element-binding Proteins (SREBP) in Alveolar Type II Cells Enhances Lipogenesis Causing Pulmonary Lipotoxicity (2012)

Pulmonary inflammation is associated with altered lipid synthesis and clearance related to diabetes, obesity, and various inherited metabolic disorders. In many tissues, lipogenesis is regulated at the transcriptional level by the activity of sterol-response element-binding proteins (SREBP). The role of SREBP activation in the regulation of lipid metabolism in the lung was assessed in mice in which both Insig1 and Insig2 genes, encoding proteins that bind and inhibit SREBPs in the endoplasmic reticulum, were deleted in alveolar type 2 cells. Although deletion of either Insig1 or Insig2 did not alter SREBP activity or lipid homeostasis, deletion of both genes (Insig1/2(Δ/Δ) mice) activated SREBP1, causing marked accumulation of lipids that consisted primarily of cholesterol esters and triglycerides in type 2 epithelial cells and alveolar macrophages. Neutral lipids accumulated in type 2 cells in association with the increase in mRNAs regulating fatty acid, cholesterol synthesis, and inflammation. Although bronchoalveolar lavage fluid phosphatidylcholine was modestly decreased, lung phospholipid content and lung function were maintained. Insig1/2(Δ/Δ) mice developed lung inflammation and airspace abnormalities associated with the accumulation of lipids in alveolar type 2 cells, alveolar macrophages, and within alveolar spaces. Deletion of Insig1/2 activated SREBP-enhancing lipogenesis in respiratory epithelial cells resulting in lipotoxicity-related lung inflammation and tissue remodeling.
Pediatric Exposure to E-Cigarettes, Nicotine, and Tobacco Products in the United States (2016)

The frequency of exposures to e-cigarettes and nicotine liquid among young children is increasing rapidly and severe outcomes are being reported. Swift government action is needed to regulate these products to help prevent child poisoning. Prevention strategies include public education; appropriate product storage and use away from children; warning labels; and modifications of e-cigarette devices, e-liquid, and e-liquid containers and packaging to make them less appealing and less accessible to children.
Recommendation in an Evolving Service Ecosystem Based on Network Prediction (2014)

Service computing plays a critical role in business automation and we can observe a rapid increase of web services and their compositions nowadays. Web services, their compositions, providers, consumers, and other entities such as context information, collectively form an evolving service ecosystem. Many service recommendation methods have been proposed to facilitate the use of services. However, existing approaches are mostly based on all-time statistics of usage patterns, and overlook the temporal aspect, i.e., the evolution of the ecosystem. As a result, recommendation may consist of obsolete services and also does not reflect the latest trend in the ecosystem. In order to overcome this limitation, we propose an innovative three-phase network prediction approach (NPA) for evolution-aware recommendation. First, we introduce a network series model to formalize the evolution of the service ecosystem and then develop a network analysis method to study the usage pattern with a special focus on its temporal evolution. Afterward a novel service network prediction method based on rank aggregation is proposed to predict the evolution of the network. Finally, using the network prediction model, we present how to recommend potential compositions, top services and service chains, respectively. Experiments on the real-world ProgrammableWeb data set show that our method achieves a superior performance in service recommendation, compared with those that are agnostic to the evolution of a service ecosystem.
Laboratory and Field Evaluation of Cement-Treated Reclaimed Asphalt Pavement Blends as Roadway Base Material (2012)

Reclaimed asphalt pavement (RAP) and granular base materials were collected throughout Texas to evaluate the properties of RAP and RAP blended with virgin or salvage aggregates for roadway base course application. Mixes containing RAP of 100 %, 75 %, and 50 % and treated with Portland cement of different dosages were utilized in a comprehensive laboratory testing program. The factors that affect the properties of cement-treated RAP mixes are identified and a mix design model based on typical RAP and granular base materials in Texas was proposed. The design model was verified by the data from the initial field trial on actual construction projects. The feasibility of using a modulus-based procedure for quality assurance/quality control during construction is discussed.
Obstacle-aware Adaptive Informative Path Planning for UAV-based Target\n Search (2019)

Target search with unmanned aerial vehicles (UAVs) is relevant problem to\nmany scenarios, e.g., search and rescue (SaR). However, a key challenge is\nplanning paths for maximal search efficiency given flight time constraints. To\naddress this, we propose the Obstacle-aware Adaptive Informative Path Planning\n(OA-IPP) algorithm for target search in cluttered environments using UAVs. Our\napproach leverages a layered planning strategy using a Gaussian Process\n(GP)-based model of target occupancy to generate informative paths in\ncontinuous 3D space. Within this framework, we introduce an adaptive replanning\nscheme which allows us to trade off between information gain, field coverage,\nsensor performance, and collision avoidance for efficient target detection.\nExtensive simulations show that our OA-IPP method performs better than\nstate-of-the-art planners, and we demonstrate its application in a realistic\nurban SaR scenario.\n
System and periodic disturbance identification for feedforward-feedback control of flexible spacecraft (1997)

This paper presents a method to identify the control-to-output dynamics of a flexible spacecraft when it is disturbed single or multiple periodic disturbances. The disturbance profiles are unknown, but their periods are assumed to be known. Available for identification are the excitation signals at the control inputs and the resultant output responses, which include the effect of the unknown, and possibly dominating disturbances. The paper offers a formulation that uniquely separates the effect of the control excitation from that of the unknown periodic disturbances so that both the control-to-output dynamics and the disturbance effect are identified correctly. This information can then be used to design both feedback and feedforward controllers. The formulation introduces a special mechanism that makes any periodic disturbance input automatically appear periodic in the output after a prespecified, generally 'small' number of time steps. This will occur regardless of the system dynamics which can be highly damped, lightly damped, or even unstable. This critical feature allows transient data to be used, eliminating the need to wait for steady-state, which is unsatisfactory for lightly-damped flexible structures. The method is illustrated by several examples, including vibration control of a communications satellite. (Author)
Studies on cytochrome c. Part I. Synthesis of the protected hexadecapeptide (sequence 1–16) of Baker's Yeast iso‐1‐cytochrome c (1973)

Abstract The general strategy for the synthesis by conventional procedure of N‐ and C‐terminal fragments and of the entire sequence of baker's yeast iso‐1‐cytochrome c is discussed. The synthesis of the N ‐benzyloxycarbonylhexadecapeptide tert ‐butoxycarbonylhydrazide corresponding to the sequence 1–16 of the apoprotein is described in detail.
Learning to control partial differential equations: Regularized Fitted Q-Iteration approach (2016)

This paper formulates a class of partial differential equation (PDE) control problems as a reinforcement learning (RL) problem. We design an RL-based algorithm that directly works with the state of PDE, an infinite dimensional vector, thus allowing us to avoid the model order reduction, commonly used in the conventional PDE controller design approaches. We apply the method to the problem of flow control for time-varying 2D convection-diffusion PDE, as a simplified model for heating, ventilating, air conditioning (HVAC) control design in a room.
Fluorescent antitumor titanium(iv) salen complexes for cell imaging (2018)

Two differently substituted fluorescent salen Ti(iv) complexes were developed. One was inactive on human cancer cells, whereas the other showed high cytotoxicity. Based on live cell imaging, both complexes penetrated the cell, but were not detected in the nuclei. Moreover, the inactive complex was trapped in endocytic vesicles, whereas the active complex accumulated in the perinuclear region and inflected phototoxicity upon continuous irradiation.
Experimental and modeling study of diauxic lag of Pseudomonas denitrificans switching from oxic to anoxic conditions. (1998)

We have shown that Pseudomonas denitrificans undergo a diauxie when switching from dissolved oxygen to nitrate as terminal electron acceptor. The length of time under aeration significantly affected the length of the diauxic lag, whereas the presence or absence of nitrate in the culture under aeration had a marginal effect. Nitrate consumption was very low during the lag period and then increased rapidly, coinciding with exponentially increasing biomass concentrations. Biochemical rate expressions that account for enzyme synthesis and activity in response to culture conditions and enzyme specific levels were developed. The new model successfully predicts the different lengths of diauxic lags observed in the experiments as well as the growth pattern and nitrate uptake.
Glycoengineering of Cyanobacterial Thylakoid Membranes for Future Studies on the Role of Glycolipids in Photosynthesis (2005)

The lipid composition of thylakoid membranes is conserved from cyanobacteria to angiosperms. The predominating components are monogalactosyl- and digalactosyldiacylglycerol. In cyanobacteria, thylakoid membrane biosynthesis starts with the formation of monoglucosyldiacylglycerol which is C4-epimerized to the corresponding galactolipid, whereas in plastids monogalactosyldiacylglycerol is formed at the beginning. This suggests that galactolipids have specific functions in thylakoids. We wanted to investigate whether galactolipids can be replaced by glycosyldiacylglycerols with headgroups differing in their epimeric and anomeric details as well as the attachment point of the terminal hexose in diglycosyldiacylglycerols. For this purpose putative glycosyltransferase sequences were identified in databases to be used for functional expression in various host organisms. From 18 newly identified sequences, four turned out to encode glycosyltransferases catalyzing final steps in glycolipid biosynthesis: two alpha-glucosyltransferases, one beta-galactosyltransferase and one beta-glucosyltransferase. Their functional annotation was based on detailed structural characterization of the new glycolipids formed in the transformant hosts as well as on in vitro enzymatic assays. The expression of alpha-glucosyltransferases in the cyanobacterium Synechococcus resulted in the accumulation of the new alpha-galactosyldiacylglycerol which is ascribed to epimerization of the corresponding glucolipid. The expression of the beta-glucosyltransferase led to a high proportion of new beta-glucosyl-(1-->6)-beta-galactosyldiacylglycerol almost entirely replacing the native digalactosyldiacylglycerol. These results demonstrate that modifications of the glycolipid pattern in thylakoids are possible.
INVESTIGATION OF SEVERAL HIGH TEMPERATURE REACTIONS INVOLVING CYANOGEN AND LIKE COMPOUNDS AS HIGH BRIGHTNESS CHEMICAL PYROTECHNIC SOURCES (1968)

Abstract : The use of a cyanogen-oxygen gaseous detonation system has been demonstrated successfully to pump both neodymium and ruby solid state lasers. Several types of pumping fixtures have been evaluated and the energy input in terms of radiation temperature have been correlated to mixture ratio, initial pressure, ignition geometry, and vessel geometry. A complete study of the radiation output of the cyanogen-oxygen gaseous detonation system including the effect of inert gas addition (helium, argon and xenon) was undertaken. The radiation temperature of the cyanogen-oxygen detonation using 52% cyanogen with the initial system pressure at 3 atm was 6300K. The use of inert additives yielded temperatures as high as 8000K. Emission spectra were taken of the detonation together with detonation velocity measurements.
Joint Precoder and Receiver Design for AF Non-Simultaneous Two-Way MIMO Relaying (2015)

We investigate a joint design of linear precoders and receivers for multiple-input multiple-output non-simultaneous two-way relaying (NS-TWR). Unlike conventional two-way relaying, the base station in NS-TWR performs two-way relaying with two different users-a transmit-only user and a receive-only user (RUE). The RUE experiences back-propagating interference (BI). The proposed design cancels this BI and provides beamforming gain over existing designs. For NS-TWR, we maximize the weighted sum-rate (WSR) through joint power allocation, by solving a sequence of geometric programs. The precoder and the receiver designs as well as the power allocation program are then extended for a multi-user system with multiple transmit-only and receive-only users. With exhaustive simulations, we show that the proposed design provides significantly better WSR than the existing ones. The proposed design is also evaluated in a cellular framework using realistic path loss models, to assess the system-level performance gain achievable.
[Digitalization in clinical microbiology]. (2022)

Reflections on digitalization in clinical microbiology are presented. The advantages and limitations of digital processing of microbiological data for individuals and the human population are considered.
Gas Chromatography (2004)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTGas ChromatographyGary A. Eiceman, Jorge Gardea-Torresdey, Ed Overton, Ken Carney, and Frank DormanView Author Information Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico 88003-0001 Department of Chemistry, University of Texas, El Paso, El Paso, Texas 79968 Louisiana State University, Baton Rouge, Louisiana 70803 Restek Corporation, Bellefonte, Pennsylvania 1682, and Chemistry Department, Juniata College, 1700 Moore Street, Huntingdon, Pennsylvania 16652 Cite this: Anal. Chem. 2004, 76, 12, 3387–3394Publication Date (Web):May 18, 2004Publication History Published online18 May 2004Published inissue 1 June 2004https://pubs.acs.org/doi/10.1021/ac0400663https://doi.org/10.1021/ac0400663review-articleACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views1740Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chromatography,Modulators,Organic compounds,Phenyls,Separation science Get e-Alerts