gebhart/patrepeval huggingface dataset:
Immunoglobulin and hepatitis B surface antigen‐specific circulating immune complexes in chronic hepatitis with hepatitis delta virus infection (1990)

IgM, IgG, and HBsAg containing circulating immune complexes (CIC) were determined, by conglutinin (K) and C1q assays, for assessing the role of CIC in hepatitis delta virus (HDV) infection in 54 HBsAg-negative controls and 85 HBsAg-positive patients with chronic hepatitis. The prevalence of HDV markers (HDV antigen and anti-HD) was 24.70% (21/85). CIC were a common feature of HDV infection with 95.24% of patients having at least one abnormal test result. The prevalence of elevated IgM-K, IgG-K, IgM-C1q, and IgG-C1q CIC were 85.71, 85.71, 57.14, and 85.71%, respectively. The prevalence of IgM class CIC were statistically higher in patients with HDV infection than in those without (P = .001 for the K assay and P = .023 for the C1q assay). There was no difference in the prevalence of IgG class CIC. Patients with HDV infection also have significantly higher median levels of IgM K-CIC (P = .002), IgG K-CIC (P = .049), and IgG C1q-CIC (P = .008). In patients with HDV infection, there was positive correlation between IgM C1q-CIC and transaminase levels (r = .519, P = .016 for AST; r = .500, P = .021 for ALT). There was no difference in the prevalence of HBsAg containing CIC between patients with HDV infection (76.19%) and those without (74.60%). In conclusion, IgM class CIC are the major CIC and correlate with disease activity in HDV infection. CIC may play a role in the pathogenesis of HDV infection.
In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion (2001)

The aims of this study were twofold: (i) to determine quantitatively the contribution of glutamate/glutamine cycling to total astrocyte/neuron substrate trafficking for the replenishment of neurotransmitter glutamate; and (ii) to determine the relative contributions of anaplerotic flux and glutamate/glutamine cycling to total glutamine synthesis. In this work in vivo and in vitro (13)C NMR spectroscopy were used, with a [2-(13)C]glucose or [5-(13)C]glucose infusion, to determine the rates of glutamate/glutamine cycling, de novo glutamine synthesis via anaplerosis, and the neuronal and astrocytic tricarboxylic acid cycles in the rat cerebral cortex. The rate of glutamate/glutamine cycling measured in this study is compared with that determined from re-analysis of (13)C NMR data acquired during a [1-(13)C]glucose infusion. The excellent agreement between these rates supports the hypothesis that glutamate/glutamine cycling is a major metabolic flux ( approximately 0.20 micromol/min/g) in the cerebral cortex of anesthetized rats and the predominant pathway of astrocyte/neuron trafficking of neurotransmitter glutamate precursors. Under normoammonemic conditions anaplerosis was found to comprise 19-26% of the total glutamine synthesis, whilst this fraction increased significantly during hyperammonemia ( approximately 32%). These findings indicate that anaplerotic glutamine synthesis is coupled to nitrogen removal from the brain (ammonia detoxification) under hyperammonemic conditions.
Analysis of equine humoral immune responses to the transmembrane envelope glycoprotein (gp45) of equine infectious anemia virus (1991)

Defined segments of the transmembrane envelope glycoprotein (gp45) of equine infectious anemia virus were expressed as TrpLE fusion proteins and examined for their reactivity in Western immunoblots against a diverse panel of equine immune sera. The most immunogenic region of gp45 was localized to its amino terminus, positioned between the hydrophobic fusion and the transmembrane domains. A series of overlapping synthetic peptides were used in enzyme-linked immunosorbent assays to define an immunodominant epitope within this region. In contrast, the carboxy-terminal half of gp45 displayed both weak and variable immunoreactivity with equine immune sera.
Cold-pressed minke whale oil reduces circulating LDL/VLDL-cholesterol, lipid oxidation and atherogenesis in apolipoprotein E-deficient mice fed a Western-type diet for 13 weeks (2018)

In the present study mice fed a WD supplemented with 1% CWO had reduced formation of atherosclerotic lesions in the aortic arch, reduced serum LDL/VLDL-cholesterol and ox-LDL-cholesterol, increased serum total antioxidant status and reduced body weight compared to mice fed a WD supplemented with 1% CO.
Effect of dislocation density on the performance of InGaN-based MJ solar cell: Analytical approach (2015)

In this study the effect of dislocation density on the performance of InGaN based multi junction solar cell has been calculated analytically. It is found that dislocation density adversely affects the open circuit voltage, short circuit current density and conversion efficiency of a solar cell. Efficiency is found to be improved with the increase in the number of junction (24.4–43.56% for single-six junction solar cells) while considering no dislocation. Whereas it is found that the efficiency is affected when dislocation density (1001−1013m−2) is incorporated for analyzing the performances of either single junction (24.47-8.25%) or multi junction solar cell (43.56-15.25% for six junctions). The effect of dislocation density on minority carrier life time is also been anticipated in this study.
Oviductal fluid protein patterns in the rhesus monkey (Macaca mulatta) during the menstrual cycle (1992)

Oviducts were obtained from monkeys on Days 8, 14, 19 and 25 of the menstrual cycle and changes in the pattern of luminal fluid proteins were examined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Densitometric analysis after periodic acid Schiff's reagent (PAS) and coomassie blue staining of the gels revealed 85 and 95 kDa proteins only up to Day 14 whereas a 130 kDa glycoprotein persisted up to Day 19 and reached a nadir at mid-menstrual cycle (Day 14). The absence of the 130 kDa glycoprotein in the serum and its presence in cytosolic preparations up to Day 19 suggest that it is of oviductal origin. The 130 kDa glycoprotein is of particular interest since it was present in the oviductal fluid during mid cycle, a period when the oviduct participates in gamete transport, fertilization and embryo development. The conclusion drawn from this study is that the protein profile of monkey oviductal fluid changes during the menstrual cycle.
Trends in Contrast Media Research (2001)

From the Department of Radiology, Scott and White Clinic and Hospital, Temple, Texas. Reprint requests: Val M. Runge, MD, Robert and Alma Moreton Centennial Chair in Radiology, Scott and White Clinic and Hospital, Texas A&M University Health Science Center, 2401 South 31st St., Temple, TX 76508; e-mail: [email protected]
Practical Software Measurement: Objective Information for Decision Makers (2001)

Foreword. Preface. Acknowledgements. 1. Measurement: Key Concepts and Practices. Motivation for Measurement. Measurement as an Organizational Discriminator. The Foundation-Project Measurement. What Makes Measurement Work. Measurement Information Model. Measurement Process Model 10. 2. Measurement Information Model. Information Needs. Measurement Construct. Measurement Construct Examples. 3. Plan Measurement. Identify and Prioritize Information Needs. Select and Specify Measures. Integrate the Measurement Approach into Project Processes. 4. Perform Measurement. Collect and Process Data. Analyze Data. Make Recommendations. 5. Analysis Techniques. Estimation. Feasibility Analysis. Performance Analysis. 6. Evaluate Measurement. Evaluate the Measures. Evaluate the Measurement Process. Update the Experience Base. Identify and Implement Improvements. 7. Establish and Sustain Commitment. Obtain Organizational Commitment. Define Measurement Responsibilities. Provide Resources. Review the Measurement Program. Lessons Learned. 8. Measure For Success. Appendix A: Measurement Construct Examples. Milestone Completion. Work Unit Progress: Software Design Progress. Incremental Capability. Personnel Effort. Financial Performance: Earned Value. Appendix B. Information System Case Study. Project Overview. Getting the Project Under Control. Evaluating Readiness for Test. Installation and Software Support. Appendix C. Xerox Case Study. Product and Project Overview. Estimation and Feasibility Analysis. Performance Analysis. Redesign and Replanning. Glossary. Bibliography. Index. 0201715163T09252001
Suicide Gene Therapy for Intrinsically Drug Resistant Solid Tumors (1997)

Abstract The failure of available anticancer drugs to cure the common human solid tumors is thought to be caused by their poor selective toxicity. As demonstrated herein, suicide gene therapy offers the potential to improve selective toxicity.
Enabling Ferroelectric Memories in BEoL - towards advanced neuromorphic computing architectures (2021)

Advanced non-volatile memory concepts such as the 1T1C ferroelectric (FE) random-access memory (FeRAM) and the 1T1C FE field-effect transistor (FeFET) can be realized by connecting a metal-ferroelectric-metal (MFM) capacitor placed in the back end of line (BEoL) of a microchip to the drain and gate contacts of a standard logic device, respectively. With the vertical distributed select devices in the front-end of line (FEoL) and the storage elements in the BEoL, both concepts increase the effective memory density of a microchip without introducing major changes in the FEoL fabrication technology. However, for advanced neuromorphic computing architectures, the 1T1C FeFET is the device of choice, since it provides non-destructive readout. The most promising material for the integration of FE non-volatile memory functionalities into the BEoL is Zr doped HfO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> (HZO). It crystallizes at low temperatures in the orthorhombic phase (the one with FE properties) and with a polycrystalline structure. The latter is important to enable analogue like switching in synaptic devices. Herein, the above-mentioned memory concepts are introduced and key steps to optimize the HZO films for the BEoL integration and for the neuromorphic computing use case are described.
TD-LTE network indoor offloading study in a realistic metropolitan scenario (2013)

In the wireless broadband network, most traffic are generated from indoor users. Meanwhile the indoor coverage is identified as the major bottleneck especially in dense urban environment with high-rising buildings. In this paper, the TD-LTE network downlink performance of indoor is studied with various network deployment options, including outdoor Macro cell, outdoor Micro cell, indoor distributed antenna system (DAS), indoor Femto cell, and their combinations in a realistic large-scale dense urban scenario. Since a DAS cell consists of several or even tens of access points (AP), the computation load is too high to be accepted when calculating the received signal power and the interference power by traditional widely-used methodology. Thus a new DAS model is proposed to decrease the computation complexity to a reasonable level in the simulation. To have more accurate channel modeling, the real three-dimensional (3D) city map of the investigated area is employed. A 3D ray-tracing tool is used to estimate the large scale propagation occurring between outdoor sites and buildings. The traffic offloading features of Micro, DAS, and Femto cell are evaluated through system simulations.
Selecting Query Term Alternations for Web Search by Exploiting Query Contexts (2008)

Query expansion by word alterations (alternative forms of a word) is often used in Web search to replace word stemming. This allows users to specify particular word forms in a query. However, if many alterations are added, query traffic will be greatly increased. In this paper, we propose methods to select only a few useful word alterations for query expansion. The selection is made according to the appropriateness of the alteration to the query context (using a bigram language model), or according to its expected impact on the retrieval effectiveness (using a regression model). Our experiments on two TREC collections will show that both methods only select a few expansion terms, but the retrieval effectiveness can be improved significantly.
IN VIVO ACTIVITY OF LEFLUNOMIDE (1999)

These studies reveal that the blood levels of A77 1726 in Lewis rats satisfy in vitro requirements for both inhibition of de novo pyrimidine synthesis and protein tyrosine kinase activity. Our data also illustrate that the in vivo mechanism of immunosuppression by leflunomide is complex and is affected by at least the following four factors: type and vigor of the immune response, availability of uridine for salvage by proliferating lymphocytes, species being investigated, and concentration of serum A77 1726.
Shoulder instability: impact of glenohumeral arthrotomography on treatment. (1986)

We used arthrotomography to study the glenoid labrum in 114 patients. Sixty-nine of the patients had anatomic instability of the shoulder (including recurrent dislocation and subluxation of the shoulder), and 45 patients had functional instability of the shoulder (denoted by chronic pain, clicking of the joint, and the sensation that an unstable condition exists without the objective signs of it). Labral tears were revealed arthrotomographically in 86% of the patients with anatomic instability, while only 40% of the patients with functional instability had labral abnormalities, and these were primarily of minor severity. Fifty-six patients (44 of whom had anatomic instability; 12, functional instability) required surgery. The surgical findings were correlated with the arthrotomographic findings, and no false-positive results were revealed. However, arthrotomography demonstrated only part of the pathologic condition of two patients. These results confirm that there is a strong correlation between labral pathologic conditions and anatomic instability of the shoulder. Arthrotomographic studies have a great impact on the selection of therapy in cases of both anatomic and functional instability of the shoulder.
Magnetic Bioactive and Biodegradable Hollow Fe-Doped Hydroxyapatite Coated Poly(l-lactic) Acid Micro-nanospheres (2013)

Superparamagnetic iron-substituted hydroxyapatite nanocrystals (FeHA) were used as a particulate emulsifier for the preparation of hybrid polymeric–inorganic materials by Pickering emulsion. As result, magnetic hollow micro-nanospheres (ranging from 2 μm to 500 nm) made of a polymeric shell of poly(l-lactic) acid coated with FeHA have been prepared. Several hybrid composites containing different amounts of inorganic phase loaded to the polymeric shell were prepared. The amount of FeHA strongly affected the chemical-physical features of the spheres such as size, polymer crystallinity, surface charge, and magnetization. They displayed good biocompatibility toward bone marrow mesenchymal stem cells, and the spheres coated with higher amount of FeHA exhibited better cell proliferation than those coated with lower amount. These magnetic materials have potential uses as building blocks for the preparation of scaffolds for hard tissue regeneration as well as carriers of biomolecules for nanomedical applications.
Correction to “A Xylochemically Inspired Synthesis of Lamellarin G Trimethyl Ether via an Enaminone Intermediate” (2019)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "A Xylochemically Inspired Synthesis of Lamellarin G Trimethyl Ether via an Enaminone Intermediate"Robin KlintworthRobin KlintworthMore by Robin Klintworth, Charles B. de KoningCharles B. de KoningMore by Charles B. de Koninghttp://orcid.org/0000-0003-4525-5130, Till OpatzTill OpatzMore by Till Opatzhttp://orcid.org/0000-0002-3266-4050, and Joseph P. Michael*Joseph P. MichaelMore by Joseph P. Michaelhttp://orcid.org/0000-0002-2307-8068Cite this: J. Org. Chem. 2019, 84, 22, 15008Publication Date (Web):November 4, 2019Publication History Published online4 November 2019Published inissue 15 November 2019https://pubs.acs.org/doi/10.1021/acs.joc.9b02925https://doi.org/10.1021/acs.joc.9b02925correctionACS PublicationsCopyright © 2019 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views751Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (273 KB) Get e-Alertsclose Get e-Alerts
Abstract 5463: Cyclophilin A Mediates Endothelial Damage and Promotes Recruitment of Inflammatory Cells and Atherosclerosis (2009)

Background- Cyclophilin A (CyPA) is a proinflammatory cytokine that is highly expressed in vascular smooth muscle cells (VSMC) in mice and humans and is also secreted from VSMC in response to reactive oxygen species (ROS). Development of atherosclerosis involves endothelial cell (EC) dysfunction and activation, vascular inflammatory cytokine release, macrophage migration/activation, and differentiation into foam cells. Based on involvement of CyPA in ROS signaling, we hypothesized that CyPA expression would be proatherogenic. Methods and Results- Using the ApoE −/− mouse model, we compared atherosclerosis development following genetic deletion of CyPA (ApoE −/− CyPA −/− ) in mice fed a high fat diet for 16 wks. Atherosclerosis was assessed by oil-red O (ORO) staining and was significantly greater in ApoE −/− mice compared with ApoE −/− CyPA −/− mice (% ORO, en face aorta; 19.3±7.5 vs. 8.2±2.0, P &lt;0.01). Immunostaining of aortic cusp revealed significant reduction of CD45 + cells, CD3 + cells, and Mac3 + cells in ApoE −/− CyPA −/− compared with ApoE −/− mice, supporting the role of CyPA in inflammatory cell recruitment. En face aortic TUNEL staining revealed significant reduction of EC apoptosis in ApoE −/− CyPA −/− compared with ApoE −/− mice (count/area; 23.1±5.5 vs. 6.8±3.2, P &lt;0.01). Moreover, ApoE −/− CyPA −/− mice had reduced expression of vascular cellular adhesion molecule 1 (VCAM-1) and increased expression of eNOS compared to ApoE −/− mice, suggesting a key role for CyPA in EC inflammation. These features were not altered by reconstitution of bone marrow cells from ApoE −/− CyPA −/− mice, suggesting that vascular-derived CyPA plays a crucial role in progression of atherosclerosis. Mechanistic experiments revealed that CyPA may be important for MCP-1 secretion from VSMC. These data are consistent with findings in humans where expression of CyPA, migration of inflammatory cells, and adhesion molecule expression are significantly augmented in ruptured atherosclerotic plaque areas of patients with acute coronary syndromes. Conclusion- CyPA is a novel mediator of atherogenesis by promoting EC damage, adhesion molecule expression, and inflammatory cell migration.
Long-Term Oral Administration of Memory-Enhancing Doses of Tacrine in Mice: A Study of Potential Toxicity and Side Effects (1987)

Recently, tacrine (1, 2, 3, 4-tetrahydro-9-aminoacridine; THA; TAC) has received international attention as an oral agent capable of relieving some of the cognitive symptoms accompanying Alzheimer's disease (AD). When given acutely and parenterally (by injection), tacrine has also enhanced memory retention in animals and man. This study evaluates the clinical potential of this agent by assessing toxicity and major side effects of a memory-enhancing dose of tacrine in mice. Groups of mice received either tacrine or vehicle (placebo) orally for 4 to 6 months. A lack of toxicity after this prolonged treatment with TAC was indicated by: (a) no significant impairment on a battery of behavioral toxicity tests; (b) improved memory retention; (c) a significant but only slight elevation of ornithine transcarbamylase activity in blood serum; (d) no abnormality as revealed with light microscopy of liver tissue; and (e) no gross organ pathology in visceral organs.
Proteinase yscD (oligopeptidase yscD) (1994)

The yeast PRD1 gene, encoding proteinase yscD, was cloned by complementation of the prd1-6 point mutation. Sequencing of the gene revealed an open reading frame of 2.136 kb, encoding a protein of 712 amino acids with a calculated molecular mass of 81.8 kDa. The sequence HEGLG beginning at residue 501 represents the HEXXH motif, unique for the zinc metallo-peptidases. Sequence comparison revealed complete identity of the proteinase yscD gene with a recently published open reading frame of yeast chromosome III. We found 34.8% identity between proteinase yscD and rat metalloendopeptidase (thimet oligopeptidase, EP 24.15). Proteinase yscD hydrolyzes several chromogenic and fluorogenic peptides that are substrates of thimet oligopeptidase. N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoic acid, a compound designed as specific inhibitor of EP 24.15, is also a strong inhibitor of the yeast enzyme. Proteinase yscD is a nonvacuolar enzyme. 3-5% of the total enzyme activity can be detected in the intermembrane space of mitochondria. In a mutant carrying a deletion of the PRD1 gene no proteinase yscD activity is detectable in the cytoplasm and in mitochondria of these cells. They do not show any grossly altered phenotype but exhibit a decrease in the intracellular degradation of peptides. This suggests a function of proteinase yscD in the late stages of protein degradation.
A secure, distributed and scalable infrastructure for remote generation and use of cryptographic keys (2020)

This paper outlines an ad-hoc architectural design and a practical implementation of a secure, distributed, fault tolerant and scalable infrastructure comprised of a distributed network of electronics hardware systems that remotely generate cryptographic keys, store them, digitally sign cryptographic transactions based on such keys, and record the transactions on a blockchain. The proposed solution is suitable to service both crypto-finance and non-finance applications, and the physical infrastructure is designed to be implemented using off-the-shelf industrial electronics, which further sustains the already scalable-by-design infrastructure architecture.