MP71-14 SIGNIFICANCE OF BUTTYRYLCHOLINESTERASE BEFORE CHEMOTHERAPY AS AN INDEPENDENT PREDICTOR OF OVER-ALL SURVIVAL IN PATIENTS WITH ADVANCED UPPER-TRACT UROTHELIAL CANCER (2017)

You have accessJournal of UrologyBladder Cancer: Upper Tract Transitional Cell Carcinoma I1 Apr 2017MP71-14 SIGNIFICANCE OF BUTTYRYLCHOLINESTERASE BEFORE CHEMOTHERAPY AS AN INDEPENDENT PREDICTOR OF OVER-ALL SURVIVAL IN PATIENTS WITH ADVANCED UPPER-TRACT UROTHELIAL CANCER Takahiro Yoneyama, Masaaki Oikawa, Kazuhisa Hagiwara, Takuma Narita, Toshikazu Tanaka, Kengo Imanishi, Tohru Yoneyama, Kazuyuki Mori, Atsushi Imai, Shingo Hatakeyama, Yasuhiro Hashimoto, Takuya Koie, and Chikara Ohyama Takahiro YoneyamaTakahiro Yoneyama More articles by this author , Masaaki OikawaMasaaki Oikawa More articles by this author , Kazuhisa HagiwaraKazuhisa Hagiwara More articles by this author , Takuma NaritaTakuma Narita More articles by this author , Toshikazu TanakaToshikazu Tanaka More articles by this author , Kengo ImanishiKengo Imanishi More articles by this author , Tohru YoneyamaTohru Yoneyama More articles by this author , Kazuyuki MoriKazuyuki Mori More articles by this author , Atsushi ImaiAtsushi Imai More articles by this author , Shingo HatakeyamaShingo Hatakeyama More articles by this author , Yasuhiro HashimotoYasuhiro Hashimoto More articles by this author , Takuya KoieTakuya Koie More articles by this author , and Chikara OhyamaChikara Ohyama More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2270AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Systemic inflammation is a common host reaction to cancer progression. Serum level of buttyrylcholinesterase (BChE) have been reported to reflect the presence of inflammation and other clinical conditions. BChE is an alphaglycoprotein found in the nervous system and liver. Its serum level is reduced in many clinical conditions, such as liver damage, injury, infection, and malignant disease. We retrospectively evaluated the potential prognostic significance of buttyrylcholinesterase before chemotherapy as an independent predictor of overall survival in patients with advanced upper-tract urothelial cancer. METHODS We treated seventy-four patients (52 men and 22 women) with advanced upper-tract urothelial cancer (UTUC) at our clinic between August 2004 and December 2015. The average age was 69.3 (43–89), and average eGFR was 50.5 (11.6–99.3) ml/minute/1.73m2. Mean observation period was 24.0 (3–96) months. Levels of serum BChE (normal range 168-470 U/L) were measured 1 week before chemotherapy. The average serum level of BChE were 240.6 U/L (53-509). The patients received 2 courses of GCarbo consisted of 800mg/m2 gemcitabine on days 1, 8, and 15 and carboplatin (AUC 4) on day 2. If this regimen was effective, another 2 courses of GCcarbo was performed. If this regimen did not induce any tumor size reduction, we switched to 2 courses of GCarboD (D; 70mg/m2) treatment as second-line treatment. RESULTS GCarbo regimen yielded 5 cases (6.8%) of CR, 32 (43.2%) of PR, and the average duration of response of 11.4 (2–29) months. GCarboD treatment was administered in 21 cases, and yielded 2 (9.5%) PR and a duration of response was 31.5(7-50) months. The median over-all survival period was 14.3 months. When analyzed by serum BChE level, the over-all survival were 22.0 months in the BChE >168 U/L group and 12.0 months in the BChE <168 group (p=0.036). The level of serum BChE showed no association with treatment effect. CONCLUSIONS Serum BChE level before chemotherapy may have the potential to predict over-all survival in patients with advanced upper-tract urothelial cancer. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e951 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Takahiro Yoneyama More articles by this author Masaaki Oikawa More articles by this author Kazuhisa Hagiwara More articles by this author Takuma Narita More articles by this author Toshikazu Tanaka More articles by this author Kengo Imanishi More articles by this author Tohru Yoneyama More articles by this author Kazuyuki Mori More articles by this author Atsushi Imai More articles by this author Shingo Hatakeyama More articles by this author Yasuhiro Hashimoto More articles by this author Takuya Koie More articles by this author Chikara Ohyama More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...