gebhart/patrepeval huggingface dataset:
Determination of weight distribution in the foot (2013)

Recent advance in the development of methods for the measurement of static weight distribution on the foot are reviewed and find that there is no low cost equipment in the present scenario to determine these parameters, developing an economical method will help the doctors to diagnose the weight distribution in the foot and the abnormality based on type of the foot. The major technical challenge is to design the individual weight measuring point without using load cell or pressure sensor, since it increases cost of the equipment. This system involves optical based weight measurement. As an additional feature, it measures the severity of loss of sensation in the foot through a Vibro-tactile threshold sensation technique. This technique help assess the degree of loss of sensation in the foot for a diabetes patient. our project involves two foot plates in which one is designed with seven LED-LDR setup and the other a dummy. Depending on the weight of the person, the intensity of light falling on the LDR from the LED varies. The detected signal is fed to the microcontroller for processing and the output is displayed in a PC monitor.
Erweiterung des Repertoires von katalytischen Antikörpern mit Aldolaseaktivität durch Kombination von reaktiver Immunisierung und Übergangszustandstheorie: neue Enantio- und Diastereoselektivitäten (1999)

Neun effiziente Aldolase-Antikörper wurden durch Verwendung des Haptens 1 hergestellt. Bei diesem Hapten sind die Konzepte der reaktiven Immunisierung und des Übergangszustandsanalogons in einem einzigen Molekül vereint. Die Charakterisierung von zwei solchen Antikörpern ergab, daß sie hocheffiziente (bis zu 1000fach wirksamer als alle bekannten katalytischen Antikörper) und enantioselektive Katalysatoren für Aldol- und Retro-Aldolreaktionen sind und umgekehrte Enantio- und Diastereoselektivitäten wie der Antikörper 38C2 aufweisen.
A MICROFLUIDIC DEVICE FOR BLOOD CELL SORTING AND (2013)

A microfluidic device was developed based on the principle of particle retention using microfilter structures with different pore sizes (10~30µm) and a micro-well structure to automatically separate Red Blood cells (RBCs), White Blood cells (WBCs), and plasma into different compartments so that blood morphology study can be performed easily. The device only allowed pure plasma to come out for further immunoassay analysis. Experiments showed that the device successfully fractionated blood components and the obtained images of various abnormal blood cells including sickle cells and immature granulocytes are indication of a patient's health status. The device presents a more practical way of blood cell analysis compared to conventional blood smears.
Spatiotemporal dynamics of self-pumped phase conjugation in a photorefractive crystal: multipattern storage using incremental recording (1996)

We investigate the spatiotemporal dynamics of self-pumped phase conjugation for superimposed incrementally recorded images. Experimental evidence of time delay in the appearance of phase-conjugation patterns was observed during both the recording and the readout phases.
Beam breakup and the conceptual design of guided and unguided accelerators (1985)

A series of drawings illustrate the beam breakup instability, laser guiding, quadrupole channels, phase mix damping, and cavity model. Model equations are solved for a continuous beam breakup model. (LEW)
Successful Aging in a 70-Year-Old Man With Down Syndrome: A Case Study (2008)

The authors present a case study of a 70-year-old man with Down syndrome ("Mr. C.") who they followed for 16 years and who does not exhibit declines in cognitive or functional capacities indicative of dementia, despite having well-documented, complete trisomy 21. The authors describe the age-associated changes that occurred over 16 years as well as provide detailed information regarding Mr. C.'s health and genetic status. To further emphasize Mr. C.'s successful aging, the authors compared his longitudinal performance profile with that of 2 peers of comparable level of intellectual functioning: 1 similar-aged man with clinical Alzheimer's disease and a younger man who was healthy. The authors present potential explanations for the phenotypic variability observed in individuals with Down syndrome.
Towards an information theoretic framework for location-based data linkage (2018)

Abstract: "A long-standing challenge for data management is the ability to correctly relate information corresponding to the same entity distributed across databases. Traditional research into record linkage has concentrated on string comparator metrics for records with common, or relatable, attributes. However, spatially distributed data are often devoid of such crucial information for database schema integration. Rather than directly relate schemas, spatially distributed data can be related through location-based linkage algorithms, which link patterns in location-specific attributes (e.g. visit). In this paper we focus on two fundamental algorithms for location-based linkage and we investigate how different distributions of how entities visit locations influence linkage performance. We begin by studying algorithm accuracy for linking real-world data. We then outline a theoretical framework rooted in information theory that allows us to provide insight into observed phenomena. Our framework also provides a useful basis for studying the performance of location-based linkage algorithms: we analyze two opposing cases where location visit patterns arise from uniform and power distributions of entities to locations. We carry out our investigations under both the assumption of complete and incomplete information. Our findings suggest that low skew distributions are more easily linked when complete information is known. In contrast, when information is incomplete high skew distributions lead to higher linkage rates."
Durability of wood-plastic composites (2006)

Deterioration is broadly defined as any negative effect on the properties of a material. The effects can be due to biological attack or to various non-living agents (sunlight, moisture, temperature), but often, deterioration results from a combination of factors. Nowhere is this more evident than with WPCs, owing to the marriage of dissimilar materials. This article examines agents that can damage WPCs, explores methods for limiting this damage, and then addresses long-term methods for assessing WPC properties related to durability.
Insulin Dynamically Regulates Calmodulin Gene Expression by Sequential O-Glycosylation and Phosphorylation of Sp1 and Its Subcellular Compartmentalization in Liver Cells (2005)

O-glycosylation and phosphorylation of Sp1 are thought to modulate the expression of a number of genes in normal and diabetic state. Sp1 is an obligatory transcription factor for constitutive and insulin-responsive expression of the calmodulin gene (Majumdar, G., Harmon, A., Candelaria, R., Martinez-Hernandez, A., Raghow, R., and Solomon, S. S. (2003) Am. J. Physiol. 285, E584-E591). Here we report the temporal dynamics of accumulation of total, O-GlcNAc-modified, and phosphorylated Sp1 in H-411E hepatoma cells by immunohistochemistry with monospecific antibodies, confocal microscopy, and matrix-assisted laser desorption and ionization-time of flight mass spectrometry. Insulin elicited sequential and reciprocal post-translational modifications of Sp1. The O-glycosylation of Sp1 and its nuclear accumulation induced by insulin peaked early (approximately 30 min), followed by a steady decline of O-GlcNAc-modified Sp1 to negligible levels by 240 min. The accumulation of phosphorylated Sp1 in the nuclei of insulin-treated cells showed an opposite pattern, increasing steadily until reaching a maximum around 240 min after treatment. Analyses of the total, O-GlcNAc-modified, or phosphorylated Sp1 by Western blot and mass spectrometry corroborated the sequential and reciprocal control of post-translational modifications of Sp1 in response to insulin. Treatment of cells with streptozotocin (a potent inhibitor of O-GlcNAcase) led to hyperglycosylation of Sp1 that failed to be significantly phosphorylated. The mass spectrometry data indicated that a number of common serine residues of Sp1 undergo time-dependent, reciprocal O-glycosylation and phosphorylation, paralleling its rapid translocation from cytoplasm to the nucleus. Later, changes in the steady state levels of phosphorylated Sp1 mimicked the enhanced steady state levels of calmodulin mRNA seen after insulin treatment. Thus, O-glycosylation of Sp1 appears to be critical for its localization into the nucleus, where it undergoes obligatory phosphorylation that is needed for Sp1 to activate calmodulin gene expression.
Problems of Irrigation in Developing Countries (1999)

This paper describes the crucial importance of irrigated agriculture to developing countries and to the world as a whole. This is followed by a summary of key problems that restrict and diminish the benefits of irrigated agriculture. Solution of these problems will above all require a holistic approach and will require changes in the institutions involved. These institutions include those of the developing countries, of the developed countries that provide aid, and of the international financing and technical-assistance agencies. Engineers in the developed countries have had, and will continue to have, a leading role but will need some redirection. ASCE could provide valuable assistance in this redirection.
Microprocessor control of a hybrid energy system (2003)

A prototype hybrid energy system consisting of a diesel-alternator operating in parallel with a battery-inverter has been assembled and tested. The controller is based on a single-chip microprocessor and is designed to optimize the operation of the system. Management of the system is based on current system status as well as system constants. The theory behind the operation of the system and the development of the control software are described, and some of the results obtained with the prototype system are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias (2015)

BCR-ABL-mediated leukemias, either Chronic Myeloid Leukemia (CML) or Philadelphia positive Acute Lymphoblastic Leukemia (ALL), are the paradigm of targeted molecular therapy of cancer due to the impressive clinical responses obtained with BCR-ABL specific tyrosine kinase inhibitors (TKIs). However, BCR-ABL TKIs do not allow completely eradicating both CML and ALL. Furthermore, ALL therapy is associated with much worse responses to TKIs than those observed in CML. The identification of additional pathways that mediate BCR-ABL leukemogenesis is indeed mandatory to achieve synthetic lethality together with TKI. Here, we review the role of BCR-ABL/protein kinase CK2 interaction in BCR-ABL leukemias, with potentially relevant implications for therapy.
Insulinotropic Effect of Citrullus colocynthis Fruit Extracts (2000)

Infusions of Citrullus colocynthis Schrad. (Cucurbitaceae) fruits are traditionally used as antidiabetic medication in Mediterranean countries, but to our knowledge no studies have been undertaken so far to determine the possible mechanisms involved in the antidiabetic properties of the fruit. The present study was designed to investigate whether these fruits possess insulinotropic effects. For this purpose, different extracts of Citrullus colocynthis seed components were obtained: RN II (crude extract), RN VI (hydro-alcoholic extract), RN X (purified extract) and RN XVII (beta-pyrazol-1-ylalanine), the major free amino acid present in the seeds. The insulin secretory effects of these different extracts were evaluated in vitro in the isolated rat pancreas and isolated rat islets in the presence of 8.3 mM glucose. All tested extracts, when perfused for 20 min at 0.1 mg/ml, immediately and significantly stimulated insulin secretion. This effect was transient. In addition, the purified extract (RN X) provoked a clear dose-dependent increase in insulin release from isolated islets. Moreover, a significant and persistant increase in pancreatic flow rate appeared during RN VI, RN X and RN XVII perfusions. In conclusion, our results show that different Citrullus colocynthis seed extracts have an insulinotropic effect which could at least partially account for the antidiabetic activities of these fruits.
In silico characterization and expression analyses of sugarcane putative sucrose non-fermenting-1 (SNF1) related kinases (2001)

Sucrose non-fermenting-1-related protein kinases (SnRKs) may play a major role in regulating gene expression in plant cells. This family of regulatory proteins is represented by sucrose non-fermenting-1 (SNF1) protein kinase in Saccharomyces cerevisiae, AMP-activated protein kinases (AMPKs) in mammals and SnRKs in higher plants. The SnRK family has been reorganized into three subfamilies according to the evolutionary relationships of their amino acid sequences. Members of the SnRK subfamily have been identified in several plants. There is evidence that they are involved in the nutritional and/or environmental stress response, although their roles are not yet well understood. We have identified at least 22 sugarcane expressed sequence tag (EST) contigs encoding putative SnRKs. The amino acid sequence alignment of both putative sugarcane SnRKs and known SnRKs revealed a highly conserved N-terminal catalytic domain. Our results indicated that sugarcane has at least one member of each SnRK subfamily. Expression pattern analysis of sugarcane EST-contigs encoding putative SnRKs in 26 selected cDNA libraries from the sugarcane expressed sequence tag SUCEST database has indicated that members of this family are expressed throughout the plant. Members of the same subfamily showed no specific expression patterns, suggesting that their functions are not related to their phylogenic relationships based on N-terminal amino acid sequence phylogenetic relationships.
Block-based Programming Enabling Students to Gain and Transfer Knowledge with a No-code Approach (2021)

In this article, we describe our experience designing and teaching a curriculum on mobile software development that has benefitted from the no-code philosophy leveraging the power of block-based programming tools. We review a journey of 10 years using block-based programming platforms to lay foundations on software development skills, and empower the creative potential of high school students. Our objective is to provide a review of the evolution, capabilities and technical coverage of the block-based software platforms, and to discuss the impact that we have observed on users and developers who have become acquainted on the use of block-based programming tools through our courses
Blockchain Radio Access Network (B-RAN): Towards Decentralized Secure Radio Access Paradigm (2019)

The relentless growth of wireless applications and data traffic continues to accentuate the long felt need for decentralized, self-managed, and cooperative network architectures. Enlightened by the power of blockchain technology, we propose a blockchain radio access network (B-RAN) architecture and develop decentralized, secure, and efficient mechanisms to manage network access and authentication among inherently trustless network entities. We further identify promising advanced functions made possible by adopting blockchain for open radio access networks. Our test results demonstrate the benefits of the B-RAN architecture. We also present a number of challenges and future research directions.
Validity and Repeatability of Saccadic Response Times Across the Visual Field in Eye Movement Perimetry (2013)

SRT as a measure for visual field responsiveness may be a potential marker to detect risk areas in specific parts of the visual field.
Splitting of the focal spot of a high numerical-aperture objective in free space (2002)

Reported in this letter is a phenomenon that the focal spot of a high numerical-aperture objective in free space can split into two spots if a ring beam is used for illumination. Diffraction by a high numerical-aperture objective results in a depolarization such that the diffracted field in the focal region includes not only a component with the same polarization as the incident beam, but also orthogonal and longitudinal components. The use of a ring beam enhances the relative contribution from the longitudinal component. As a result, a single focal spot splits into two spots along the incident polarization direction. It is revealed theoretically that for an objective of given numerical aperture there is a threshold of the central obstruction size of a ring beam for the appearance of a two-peak focus.
Hybrid Seismic Denoising Using Higher‐Order Statistics and Improved Wavelet Block Thresholding (2016)

We introduce a nondiagonal seismic denoising method based on the continuous wavelet transform with hybrid block thresholding (BT). Parameters for the BT step are adaptively adjusted to the inferred signal property by minimizing the unbiased risk estimate of Stein (1980). The efficiency of the denoising for seismic data has been improved by adapting the wavelet thresholding and adding a preprocessing step based on a higher‐order statistical analysis and a postprocessing step based on Wiener filtering. Application of the proposed method on synthetic and real seismic data shows the effectiveness of the method for denoising and improving the signal‐to‐noise ratio of local microseismic, regional, and ocean bottom seismic data.
A New United Atom Force Field for Adsorption of Alkenes in Zeolites (2008)

A new united atom force field was developed that accurately describes the adsorption properties of linear alkenes in zeolites. The force field was specifically designed for use in the inhomogeneous system and therefore a truncated and shifted potential was used. With the determined force field, we performed a comparative study on the adsorption behaviors of ethene and propene in four pure-silica small-pore eight-membered-ring zeolites, CHA, DDR, ITE, and IHW (named Chabazite, DD3R, ITQ-3, and ITQ-32, respectively), characterized for their paraffin/olefin separation capability. The different macroscopic adsorption behaviors of alkenes in the four zeolites were elucidated and related to their structures with the microscopic information obtained from the molecular simulations providing useful information for further rational design of such zeolites with tailored properties.
Chemical, enzymological and pharmacological equivalence of urokinases isolated from genetically transformed bacteria and human urine. (1985)

Low molecular weight urokinase (LUK), which was prepared from E. coli containing a plasmid coding for human pro-urokinase, has an amino acid sequence identical to that of LUK isolated from human urine (uLUK) but lacks the carbohydrate side chain at Asn 144 of the B chain. This chemical difference results in an altered mobility in SDS polyacrylamide gel electrophoresis and an apparently increased specific activity of the E. coli-derived product (cLUK) in diffusion-limited test systems (fibrin agar plate tests). Comparative enzymological investigations in homogeneous phases reveal that the active centers and the substrate recognition sites of cLUK and uLUK are congruent. No significant difference between the enzymes was detectable in the following parameters: Michaelis constants and maximum velocities with the synthetic substrate S-2444; activation rates of human and porcine plasminogen; specificity for ten chromogenic substrates; inhibition constants for the competitive inhibitor benzamidine; inhibition by placental urokinase inhibitor and polyclonal antibodies. Further, cLUK and uLUK dissolved fibrin clots prepared from human plasma in vitro with essentially identical velocities. Both, cLUK and uLUK efficiently lysed injected emboli in rabbits and prevented renal fibrin deposition and death due to endotoxin infusion in rats. It is concluded that cLUK, despite the lack of the carbohydrate side chain, is functionally identical and pharmacologically equivalent to uLUK.
Physical organic probes of interfacial wettability reveal the importance of surface dipole effects (2000)

The interfacial wettabilities of self-assembled monolayers (SAMs) on gold generated from trifluoromethyl- and methyl-terminated alkanethiols were evaluated using a combination of non-polar, polar protic and polar aprotic contacting liquids. The wettabilities for the non-polar hydrocarbon liquids indicate that the fluorinated films are wet less than the hydrocarbon films, demonstrating the non-ideal nature of dispersive interactions between hydrocarbons and fluorocarbons. In contrast, the wettabilities for the polar liquids revealed that the fluorinated films were wet more than the hydrocarbon films. The presence of interactions between the dipoles of the liquid molecules and oriented CF3–CH2 dipoles at the monolayer surface was proposed to rationalize the observed trends. Furthermore, the wettabilities of the polar aprotic liquids exhibited an inverse odd–even trend that supports the existence of oriented dipole effects upon wettability. The influence of the dipoles on the interfacial wettabilities was further examined using a series of SAMs generated from terminally fluorinated hexadecanethiols having an increasing degree of fluorination. As the dipoles were buried further into the monolayer surface, their influence on the wettabilities decreased. The interfacial energies of wetting for these films were evaluated in terms of their works of adhesion. These analyses provided evidence for the contribution of oriented dipoles to the interfacial interactions of organic thin films, in addition to the commonly recognized contributions of dispersive and acid–base interactions. Copyright © 2000 John Wiley & Sons, Ltd.
Visualization of corneal vascularization in peripheral hypertrophic subepithelial corneal opacification with OCT angiography (2018)

Optical coherence tomography angiography allows better visualization of corneal neovascularization than slit lamp photography in patients with PHSCO. Corneal opacifications were found predominantly nasally, which was reflected by a local enlargement of corneal thickness.
The New Moving Ground System of the Pininfarina Wind Tunnel (2007)

&lt;div class="htmlview paragraph"&gt;Starting from September 2006, a new Moving Ground System is in operation in the Pininfarina wind tunnel. This system has replaced the old one, in service since 1995, which was the first in the world with a narrow belt integrated into the balance/turntable.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The new Moving Ground System has a number of improvements, namely: &lt;ul class="list nostyle"&gt; &lt;li class="list-item"&gt; &lt;div class="htmlview paragraph"&gt;- An increased top speed, up to 250 Km/h.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt; &lt;div class="htmlview paragraph"&gt;- A much longer and slightly wider central belt, e.g. it is 6.7 m long and 1.1 m wide.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt; &lt;div class="htmlview paragraph"&gt;- Two additional belts at the sides.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt; &lt;div class="htmlview paragraph"&gt;- A number of innovative features that make this system well suited for testing racing cars.&lt;/div&gt;&lt;/li&gt;&lt;/ul&gt;&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;In particular, this system has two additional belts at the sides of the central belt to cover the part of the ground that is under the car front end, for a width of 2.5 m and a length of 1.5 m.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This feature, patented by Pininfarina, greatly improves the simulation of the flow under the front wing of a Formula 1 car or under the front end of a racing car.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Details are shown in the paper.&lt;/div&gt;