gebhart/patrepeval huggingface dataset:
Synthesis of the Fully Functionalized Bicyclic Core of Garsubellin A (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSynthesis of the Fully Functionalized Bicyclic Core of Garsubellin AK. C. Nicolaou, J. A. Pfefferkorn, S. Kim, and H. X. WeiView Author Information Department of Chemistry and The Skaggs Institute for Chemical Biology The Scripps Research Institute 10550 North Torrey Pines Road La Jolla, California 92037 Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman Drive, La Jolla, California 92093 Cite this: J. Am. Chem. Soc. 1999, 121, 19, 4724–4725Publication Date (Web):May 4, 1999Publication History Received22 February 1999Published online4 May 1999Published inissue 1 May 1999https://pubs.acs.org/doi/10.1021/ja9905445https://doi.org/10.1021/ja9905445rapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1985Altmetric-Citations81LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Anions,Cyclization,Ketones,Lactones,Oxidation Get e-Alerts
Positive biocompatibility of nanocrystalline glass-like carbon thin films (2016)

Este abstract fue publicado en: J Physiol Biochem (2016) (Suppl 1): S1-S111, pg S85
Preparation of Renewable Epoxy-Amine Resins With Tunable Thermo-Mechanical Properties, Wettability and Degradation Abilities From Lignocellulose- and Plant Oils-Derived Components (2019)

One-hundred percent renewable triphenol-GTF-(glycerol trihydroferulate) and novel bisphenols-GDF<sub>x</sub>-(glycerol dihydroferulate) were prepared from lignocellulose-derived ferulic acid and vegetal oil components (fatty acids and glycerol) using highly selective lipase-catalyzed transesterifications. Estrogenic activity tests revealed no endocrine disruption for GDF<sub>x</sub> bisphenols. Triethyl-benzyl-ammonium chloride (TEBAC) mediated glycidylation of all bis/triphenols, afforded innocuous bio-based epoxy precursors GDF<sub>x</sub>EPO and GTF-EPO. GDF<sub>x</sub>EPO were then cured with conventional and renewable diamines, and some of them in presence of GTF-EPO. Thermo-mechanical analyses (TGA, DSC, and DMA) and degradation studies in acidic aqueous solutions of the resulting epoxy-amine resins showed excellent thermal stabilities (<i>T</i> <sub>d</sub>5% = 282-310°C), glass transition temperatures (<i>T</i> <sub><i>g</i></sub> ) ranging from 3 to 62°C, tunable tan α, and tunable degradability, respectively. It has been shown that the thermo-mechanical properties, wettability, and degradability of these epoxy-amine resins, can be finely tailored by judiciously selecting the diamine nature, the GTF-EPO content, and the fatty acid chain length.
Absolute rate constants for hydrocarbon autoxidation. XIV. Termination rate constants for tertiary peroxy radicals (1969)

Absolute rate constants for chain termination by ten t-peroxy radicals have been measured at 30° by the rotating sector technique, the photochemical pre- and after-effect method, and by electron spin resonance. The different methods generally give results in good agreement with one another. The termination rate constants vary from a low of ∼4 × 10 2 M −1 s −1 for t-butylperoxy to a high of ∼3 × 10 4 M −1 s −1 for 1,1-diphenylethylperoxy radicals.
Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart. (1993)

We have cloned and sequenced cDNAs for three isoforms of the L-type voltage-dependent calcium channel beta subunit isolated from a normal human heart cDNA library. One of these subunits, designated beta a, hybridized with a 3.4-kb message, and the other two, designated beta b and beta c, hybridized with a message of approximately 1.9 kb. The presence of both of these latter two messages in human heart was confirmed by polymerase chain reaction methodology. Considering the differences between beta a and beta b/beta c, we find it likely that these messages may be encoded by two different gene sequences, beta a and beta b/beta c, and that the beta b/beta c sequence can be alternatively spliced in the 209-260 region. The data suggest that the human heart presents a different pattern of beta subunit expression from that found in the rat and rabbit heart.
Depth estimation, spatially variant image registration, and super-resolution using a multi-lenslet camera (2010)

With a multi-lenslet camera, we can capture multiple low resolution (LR) images of the same scene and use them to reconstruct a high resolution (HR) image. For this purpose, two major computation problems need to be solved, the image registration and the super resolution (SR) reconstruction. For the first, one major hurdle is the spatially variant shifts estimation, because objects in a scene are often at different depths, and due to parallax, shifts between imaged objects often vary on a pixel basis. This poses a great computational challenge as the problem is NP complete. The multi-lenslet camera with a single focal plane provides us a unique opportunity to take advantage of the parallax phenomenon, and to directly relate object depths with their shifts, and thus we essentially reduced the parameter space from a two dimensional (x, y) space to a one dimensional depth space, which would greatly reduce the computational cost. As results, not only we have registered LR images, the estimated depth map can also be valuable for some applications. After registration, LR images along with estimated shifts can be used to reconstruct an HR image. A previously developed algorithm will be employed to efficiently compute for a large HR image in the size of 1024x1024.
The Detection and Measurement of Infra-Red Radiation (1969)

Share Icon Share Twitter Facebook Reddit LinkedIn Reprints and Permissions Cite Icon Cite Search Site Citation R. A. Smith, F. E. Jones, R. P. Chasmar, Herbert Malamud; The Detection and Measurement of Infra-Red Radiation. Physics Today 1 July 1969; 22 (7): 83. https://doi.org/10.1063/1.3035697 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentPhysics Today Search Advanced Search
The Application of Visualization and Simulation in a Dismantling Process (2007)

The lack of as-built drawings and information for many old nuclear facilities impedes the planning for a decommissioning. Traditional manual walkthroughs subject workers to lengthy exposure to radiological and other hazards. And also there have been a delay in the dismantling schedules and that in an increase in the amount of waste, which have caused a heavy expenditure for the decommissioning cost. In order for a 3D model to represent the real dismantling operation environment, realistic dismantling activities and scenarios were modeled. We present a dismantling digital mock-up system that can show a dismantling process through an animation and enable us to evaluate the major parameters that can directly affect the cost in a static simulation as a preview to the dismantling activities on a hypothetical dismantling environment. We carried out a prototype 3D animation and a simulation system for dismantling the thermal column in Korean Research Reactor-1(KRR-1). The results show that the modeling of a realistic scenario makes it possible to demonstrate the adequacy of the design and can provide operators with a high fidelity under the real working conditions.
Velocity estimation and downward continuation by wavefront synthesis (1978)

Abstract A 'wave stack' is any stack over a common shot or geophone gather in which the moveout is independent of time. It synthesizes a particular wavefront by superposition of the many spherical wavefronts of raw data. Unlike the common midpoint stack, wave stacks retain the important property of being the sampling of a wave field and, as such, permit wave-equation treatment of formerly difficult or impossible problems.Seismic sections of field data generated by wave stacks that synthesized slanted downgoing plane waves showed a similarity in appearance to the common midpoint stacks. In signal-to-noise ratio they lay between the single offset section and the midpoint stack. The angle selectivity of the slanted plane-wave stacks permitted detection of a reflector that was not visible on either the midpoint stack or the raw gathers.Simple velocity estimation in slant frame coordinates differs only in detail from standard frame coordinates. Because of the wave field character of data that have been slant plane-wave stacked, wave-equation techniques can be used to generalize migration and velocity estimation to regions in which exist a strong lateral velocity inhomogeneity within the distance of a cable spread.
Coordination of Voluntary and Stimulus-Driven Attentional Control in Human Cortex (2005)

Visual attention may be voluntarily directed to particular locations or features (voluntary control), or it may be captured by salient stimuli, such as the abrupt appearance of a new perceptual object (stimulus-driven control). Most often, however, the deployment of attention is the result of a dynamic interplay between voluntary attentional control settings (e.g., based on prior knowledge about a target's location or color) and the degree to which stimuli in the visual scene match these voluntary control settings. Consequently, nontarget items in the scene that share a defining feature with the target of visual search can capture attention, a phenomenon termed contingent attentional capture. We used functional magnetic resonance imaging to show that attentional capture by target-colored distractors is accompanied by increased cortical activity in corresponding regions of retinotopically organized visual cortex. Concurrent activation in the temporo-parietal junction and ventral frontal cortex suggests that these regions coordinate voluntary and stimulus-driven attentional control settings to determine which stimuli effectively compete for attention.
Modelling flavoenzymatic charge transfer events: development of catalytic indole deuteration strategies (2016)

The formation and chemistry of flavin-indole charge transfer (CT) complexes has been studied using a model cationic flavin. The ability to form a CT complex is sensitive to indole structure as gauged by spectroscopic, kinetics and crystallographic studies. Single crystals of sufficient quality of a flavin-indole CT complex, suitable for X-ray diffraction, have been grown, allowing solid-state structural analysis. When CT complex formation is conducted in d4-methanol, an efficient and synthetically useful C-3 indole deuteration is observed.
Synthesis of Acrylonitriles via Mild Base Promoted Tandem Nucleophilic Substitution‐Isomerization of α‐Cyanohydrin Methanesulfonates (2020)

Abstract Main observation and conclusion We have developed an efficient synthesis of acrylonitriles via mild base promoted tandem nucleophilic substitution‐isomerization of α‐cyanohydrin methanesulfonates with alkenylboronic acids. This transition metal‐free protocol works under simple and mild conditions and offers good chemical yields for a wide range of substrates and demonstrates good functional group tolerance. image
Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer (2006)

Circulating endothelial cells (CECs) as well as bone-marrow-derived endothelial precursor cells (EPC) play an important role in neovascularisation and tumour growth. To study the impact of neoadjuvant chemotherapy on the amounts of CEC and their precursor cells, mature CEC and their progenitors were quantified by flow cytometry in peripheral blood of breast cancer patients during anthracycline and/or taxane based neoadjuvant chemotherapy and subsequent surgery in comparison to age-matched healthy controls. Cell numbers were tested for correlation with serum levels of angiopoietin-2, erythropoietin, endostatin, endoglin, VEGF and sVCAM-1 as well as clinical and pathological features of breast cancer disease. Circulating endothelial cells were significantly elevated in breast cancer patients and decreased during chemotherapy, whereas EPC (CD34+/VEGFR-2+) as well as their progenitor cell population CD133+/CD34+ and the population of CD34+ stem cells increased. Concomitantly with the increase of progenitor cells an increase of VEGF, erythropoietin and angiopoietin-2 was observed. These data suggest that chemotherapy can only reduce the amounts of mature CEC, probably reflecting detached cells from tumour vessels, whereas the EPC and their progenitors are mobilised by chemotherapy. Since this mobilisation of EPC may contribute to tumour neovascularisation an early antiangiogenic therapy in combination with chemotherapy could be beneficial for the success of cancer therapy.
Characterization of Arabidopsis AtAMT2, a High-Affinity Ammonium Transporter of the Plasma Membrane (2002)

AtAMT2 is an ammonium transporter that is only distantly related to the five members of the AtAMT1 family of high-affinity ammonium transporters in Arabidopsis. The short-lived radioactive ion (13)NH(4)(+) was used to show that AtAMT2, expressed in yeast (Saccharomyces cerevisiae), is a high-affinity transporter with a K(m) for ammonium of about 20 microM. Changes in external pH between 5.0 and 7.5 had little effect on the K(m) for ammonium, indicating that NH(4)(+), not NH(3), is the substrate for AtAMT2. The AtAMT2 gene was expressed in all organs of Arabidopsis and was subject to nitrogen (N) regulation, at least in roots where expression was partially repressed by high concentrations of ammonium nitrate and derepressed in the absence of external N. Although expression of AtAMT2 in shoots responded little to changes in root N status, transcript levels in leaves declined under high CO(2) conditions. Transient expression of an AtAMT2-green fluorescent protein fusion protein in Arabidopsis leaf epidermal cells indicated a plasma membrane location for the AtAMT2 protein. Thus, AtAMT2 is likely to play a significant role in moving ammonium between the apoplast and symplast of cells throughout the plant. However, a dramatic reduction in the level of AtAMT2 transcript brought about by dsRNA interference with gene expression had no obvious effect on plant growth or development, under the conditions tested.
Melatonin Maintains Homeostasis and Potentiates the Anti-inflammatory Response in Staphylococcus aureus-Induced Mastitis through microRNA-16b/YAP1 (2022)

<i>Staphylococcus aureus</i> is a highly infectious pathogen and is a considerable threat to food hygiene and safety. Although melatonin is thought to exert an ameliorative effect on bovine mastitis, the regulatory mechanisms are unclear. In this study, we first verified the therapeutic effect of melatonin against <i>S. aureus</i> in vitro and in vivo, a screening of differentially expressed miRNAs and mRNAs among the blank, and <i>S. aureus</i> and melatonin + <i>S. aureus</i> groups by high-throughput sequencing identified miR-16b and <i>YAP1</i>, which exhibited 1.95-fold upregulated and 1.05-fold downregulated expression, respectively. Moreover, epigenetic studies showed that <i>S. aureus</i> inhibited miR-16b expression by methylation (increased DNMT1 expression). Additionally, the <i>DNMT1</i> expression level was significantly decreased by melatonin treatment, which might indicate that the inhibition of <i>DNMT1</i> by melatonin reduces the effect of <i>S. aureus</i> on miR-16b. The flow cytometry, scanning and transmission electron microscopy, EdU assay, and cell morphology results indicated that miR-16b in bovine mammary epithelial cells (in vitro) and in mice (in vivo) can modulate the maintenance of homeostasis and potentiate the anti-inflammatory response. In addition, <i>YAP1</i> was demonstrated to be the target gene of miR-16b through quantitative real-time polymerase chain reaction, western blot, RNA immunoprecipitation, and functional assays. This study indicates that melatonin inhibits <i>S. aureus</i>-induced inflammation via microRNA-16b/<i>YAP1</i>-mediated regulation, and these findings might provide a new strategy for the prevention of bovine mastitis, facilitating further studies good of zoonotic diseases caused by <i>S. aureus</i> infection.
Agility and Traction for a Lunar Rough Terrain Exploration Rover (2011)

So far, exploration rovers on moon and mars limited there traverses to mostly flat and easy surfaces. On the other hand, there is Opportunity or the Mars Exploration Rover-B (MER-B) getting stuck in a 30 cm sand-dune on April 26, 2005. It took until June 4, 2005 for the rover to reach firm ground again. However, many important areas to be explored on mars and moon will require a rover to travel through uneven terrain covered with rocks, craters, and crevices. This paper presents the results of preliminary work in designing and testing a locomotion system offering high agility and wheels for the Extreme Rough Terrain Lunar Exploration Rover (ERTLER). The goal of the ERTLER is to position itself on top of lava tubes or steep crater walls, to install a drill-rig, to drill and extract a sample from inside a closed section of a tube. The locomotion concept is based on wheels mounted on six individually articulated legs. To add further agility, the head section can be separately articulated around three axis. Similar to a scraper, ERTLER is capable to make tight turns. Having each wheel individually powered and articulated will allow it to overcome steep slopes, cross crevices or inchworm itself out of difficult situations. The paper will present the tests of the first prototype in a mock lunar surfaces consisting of lunar soil simulant, craters, and rocks. A special section will focus on the design and testing of a rough-terrain wheel.
Dummy-feature placement for chemical-mechanical polishing uniformity in a shallow-trench isolation process (2002)

Manufacturability of a design that is processed with shallow-trench isolation (STI) depends on the uniformity of the chemical-mechanical polishing (CMP) step in STI. The CMP step in STI is a dual-material polish for which all previous studies on dummy-feature placement for single-material polish by Kahng et al. (1999), Tian et al. (2000), and Chen et al. (2000) are not applicable. Based on recent semiphysical models of polish-pad bending by Ouma et al (1998), local polish-pad compression by Grillaert (1999) and Smith (1999), and different polish rates for materials present in a dual-material polish by Grillaert (1999) and Tugbawa et al. (1999), this paper derives a time-dependent relation between post-CMP topography and layout pattern density for CMP in STI. Using the dependencies derived, the first formulation of dummy-feature placement for CMP in STI is given as a nonlinear-programming problem. An iterative approach is proposed to solve the dummy-feature placement problem. Computational experience on four layouts from Motorola is given.
Exposition temporaire “Face of medicine” à l’Intermediatheque Museum de Tokyo (2017)

Bonté Frédéric. Exposition temporaire “Face of medicine” à l’Intermediatheque Museum de Tokyo. In: Revue d'histoire de la pharmacie, 104e année, N. 396, 2017. pp. 579-580.
Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device (2016)

Three-dimensional (3D) tumor spheroid possesses great potential as an in vitro model to improve predictive capacity for pre-clinical drug testing. In this paper, we combine advantages of flow cytometry and microfluidics to perform drug testing and analysis on a large number (5000) of uniform sized tumor spheroids. The spheroids are formed, cultured, and treated with drugs inside a microfluidic device. The spheroids can then be harvested from the device without tedious operation. Due to the ample cell numbers, the spheroids can be dissociated into single cells for flow cytometry analysis. Flow cytometry provides statistical information in single cell resolution that makes it feasible to better investigate drug functions on the cells in more in vivo-like 3D formation. In the experiments, human hepatocellular carcinoma cells (HepG2) are exploited to form tumor spheroids within the microfluidic device, and three anti-cancer drugs: Cisplatin, Resveratrol, and Tirapazamine (TPZ), and their combinations are tested on the tumor spheroids with two different sizes. The experimental results suggest the cell culture format (2D monolayer vs. 3D spheroid) and spheroid size play critical roles in drug responses, and also demonstrate the advantages of bridging the two techniques in pharmaceutical drug screening applications.
Dynamic Aha1 co‐chaperone binding to human Hsp90 (2019)

Hsp90 is an essential chaperone that requires large allosteric changes to determine its ATPase activity and client binding. The co-chaperone Aha1, which is the major ATPase stimulator in eukaryotes, is important for regulation of Hsp90's allosteric timing. Little is known, however, about the structure of the Hsp90/Aha1 complex. Here, we characterize the solution structure of unmodified human Hsp90/Aha1 complex using NMR spectroscopy. We show that the 214-kDa complex forms by a two-step binding mechanism and adopts multiple conformations in the absence of nucleotide. Aha1 induces structural changes near Hsp90's nucleotide-binding site, providing a basis for its ATPase-enhancing activity. Our data reveal important aspects of this pivotal chaperone/co-chaperone interaction and emphasize the relevance of characterizing dynamic chaperone structures in solution.