gebhart/patrepeval huggingface dataset:
Effects of some Antihypertensive Drugs on Cutaneous Blood Flow and Inflammatory Skin Responses Following Allergen Challenge in Guinea Pigs (1987)

The effects of the antihypertensive drugs clonidine, prazosin, and MK 422 (the active parent diacid of enalapril) were studied on the cutaneous blood flow and allergen evoked inflammatory skin reactions in ovalbumin sensitized guinea pigs. The hypotensive effect of the drugs did not significantly change the basal cutaneous blood flow at the time of allergen challenge. MK 422 (0.02 mg/kg) markedly enhanced the wheal and flare reaction following allergen challenge, whereas clonidine (0.005 and 0.05 mg/kg) inhibited the inflammatory response. Prazosin (0.03 mg/kg) did not significantly influence the wheal and flare reaction. Our results indicate that some antihypertensive drugs (clonidine) could be beneficial to antihypertensive patients with inflammatory diseases, while others (ACE-inhibitors) may enhance their inflammatory disorders.
Networks of compound object comparators (2013)

We discuss the theoretical background and some practical implementations of multilayered networks of units, which compare compound objects for the purposes of their identification, matching and parsing. We show how our approach arises from the previous research on fuzzy comparators. We also show in what sense the flow of information in the considered networks follows the principles of rough mereology. Finally, we present some case studies of utilization of networks of comparators in the image and text processing.
Investigation of the conformation changes of myoglobin by an electrochemical method and a biosensing application based on controlled protein unfolding (2015)

The conformational changes of myoglobin (Mb) during urea-induced unfolding were investigated using an electrochemical method.
Supplementary Table from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets (2023)

Supplementary Table from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets
UWB-IR transceiver for millimeter wave WLAN (2006)

The purpose of this paper is to demonstrate the high potentiality in terms of data rate and multiple access of a novel 60 GHz WLAN architecture for smart objects and indoor communication systems. This approach is based on the up-conversion of an ultra wide bandwidth impulse radio signal (IR-UWB) in the 60 GHz frequency range to benefit of the natural advantages of the UWB technique while avoiding the base band limitations (FCC part 15, interferences, antenna size,...). This complete architecture has been designed using a pHEMT foundry process (f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> = 100 GHz). Each mm-wave and base band devices have been tested: mm-wave source, modulator, amplifiers, RF detector and correlator. The final demonstrator is fully monolithically integrated. A space division multiple access (SDMA) multi users is now under test using smart antennas. This is done using quasi-YAGI antennas switched with RF MEMS. In fact, future high data rate WLAN (wireless local area network) will be realized using smart antennas to reduce in the same time the consumption, the link budget and the multipath effects
Influence of silica sources on structure of silica MCM-41 mesoporous molecular sieves (2001)

MCM 41 mesoporous molecular sieve was synthesized from sodium silicate, tetraethyl orthosilicate(TEOS) and cetyltrimethylammonium bromide(CTMA).Influence of different silica sources on synthesis of MCM 41 was investigated by XRD, IR and TG DTG. Possible mechanisms for the synthesis were discussed. Experiment showed that properties of the silica MCM 41 synthesized from TEOS were superior than that from sodium silicate.
The role of interleukin-1 in the dynamics of exercise-induced copeptin (2019)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Performance study of a multithreaded superscalar microprocessor (2002)

This paper describes a technique for improving the performance of a superscalar processor through multithreading. The technique exploits the instruction-level parallelism available both inside each individual stream, and across streams. The former is exploited through out-of-order execution of instructions within a stream, and the latter through execution of instructions from different streams simultaneously. Aspects of multithreaded superscalar design, such as fetch policy, cache performance, instruction scheduling, and functional unit utilization are studied. We analyze performance based on the simulation of a superscalar architecture and show that it is possible to provide support for multiple streams with minimal extra hardware, yet achieving significant performance gain (20-55%) across a range of benchmarks.
Monolithic perovskite/silicon tandem solar cell with >29% efficiency by enhanced hole extraction (2020)

Tandem solar cells that pair silicon with a metal halide perovskite are a promising option for surpassing the single-cell efficiency limit. We report a monolithic perovskite/silicon tandem with a certified power conversion efficiency of 29.15%. The perovskite absorber, with a bandgap of 1.68 electron volts, remained phase-stable under illumination through a combination of fast hole extraction and minimized nonradiative recombination at the hole-selective interface. These features were made possible by a self-assembled, methyl-substituted carbazole monolayer as the hole-selective layer in the perovskite cell. The accelerated hole extraction was linked to a low ideality factor of 1.26 and single-junction fill factors of up to 84%, while enabling a tandem open-circuit voltage of as high as 1.92 volts. In air, without encapsulation, a tandem retained 95% of its initial efficiency after 300 hours of operation.
Depletion of high-content CD14+ cells from apheresis products is critical for successful transduction and expansion of CAR T cells during large-scale cGMP manufacturing (2021)

With the US Food and Drug Administration (FDA) approval of four CD19- and one BCMA-targeted chimeric antigen receptor (CAR) therapy for B cell malignancies, CAR T cell therapy has finally reached the status of a medicinal product. The successful manufacturing of autologous CAR T cell products is a key requirement for this promising treatment modality. By analyzing the composition of 214 apheresis products from 210 subjects across eight disease indications, we found that high CD14<sup>+</sup> cell content poses a challenge for manufacturing CAR T cells, especially in patients with non-Hodgkin's lymphoma and multiple myeloma caused by the non-specific phagocytosis of the magnetic beads used to activate CD3<sup>+</sup> T cells. We demonstrated that monocyte depletion via rapid plastic surface adhesion significantly reduces the CD14<sup>+</sup> monocyte content in the apheresis products and simultaneously boosts the CD3<sup>+</sup> content. We established a 40% CD14<sup>+</sup> threshold for the stratification of apheresis products across nine clinical trials and demonstrated the effectiveness of this procedure by comparing manufacturing runs in two phase 1 clinical trials. Our study suggests that CD14<sup>+</sup> content should be monitored in apheresis products, and that the manufacturing of CAR T cells should incorporate a step that lessens the CD14<sup>+</sup> cell content in apheresis products containing more than 40% to maximize the production success.
β-Fibrillogenesis from Rigid-Rod β-Barrels: Hierarchical Preorganization Beyond Microns (2001)

Delightful order and beauty is exhibited by novel supramolecular architectures constructed from preorganizing rigid-rod molecules which first self-assemble into β-barrel tertiary structures (left) and then transform into higher-order quaternary structures (right), that is, “rigid-rod β-fibrils”.
Data from Integrative Analysis of Genomic Aberrations Associated with Prostate Cancer Progression (2023)

&lt;div&gt;Abstract&lt;p&gt;Integrative analysis of genomic aberrations in the context of trancriptomic alterations will lead to a more comprehensive perspective on prostate cancer progression. Genome-wide copy number changes were monitored using array comparative genomic hybridization of laser-capture microdissected prostate cancer samples spanning stages of prostate cancer progression, including precursor lesions, clinically localized disease, and metastatic disease. A total of 62 specific cell populations from 38 patients were profiled. Minimal common regions (MCR) of alterations were defined for each sample type, and metastatic samples displayed the most number of alterations. Clinically localized prostate cancer samples with high Gleason grade resembled metastatic samples with respect to the size of altered regions and number of affected genes. A total of 9 out of 13 MCRs in the putative precursor lesion, high-grade prostatic intraepithelial neoplasia (PIN), showed an overlap with prostate cancer cases (amplifications in 3q29, 5q31.3-q32, 6q27, and 8q24.3 and deletions in 6q22.31, 16p12.2, 17q21.2, and 17q21.31), whereas postatrophic hyperplasia (PAH) did not exhibit this overlap. Interestingly, prostate cancers that do not overexpress ETS family members (i.e., gene fusion–negative prostate cancers) harbor differential aberrations in 1q23, 6q16, 6q21, 10q23, and 10q24. Integrative analysis with matched mRNA profiles identified genetic alterations in several proposed candidate genes implicated in prostate cancer progression. [Cancer Res 2007;67(17):8229–39]&lt;/p&gt;&lt;/div&gt;
Degenerative aneurysm of the descending aorta. Endovascular treatment (2007)

The incidence of thoracic aortic aneurysms has a rate of occurrence of 10.9 cases per 100,000 person/year, with an estimated 5-year risk of rupture ranging from 16% (diameter between 4 and 5.9 cm) to 31% (6 cm or more). Despite increasing awareness of the important role of early diagnosis in treatment options, guidelines about therapeutic strategies are actually lacking, as well as definite evidence of pharmacological treatment able to resolve or delay the disease progression. Endovascular treatment proposed as alternative to surgery has been considered a therapeutic innovation, especially because of low invasiveness, which allows to treat even high surgical risk patients. The procedure is performed under general anesthesia, mechanical ventilation and blood pressure invasive monitoring (right radial artery cannulation). The common femoral artery or external iliac artery are used for access after surgical exposure. After exposition of the artery, a 6F sheath is inserted and 5000 UI of heparin administered. Angiography is then performed to identify the lesion, landing zones and its relation to side branches. Endovascular stent-graft is thus loaded on an extra-stiff guidewire and delivered, with induced hypotension, under fluoroscopic and transesophageal echo control. Post procedural angiography and echocardiography control are performed to reveal the final result.
Clinical documents: attribute-values entity representation,context, page layout and communication. (2003)

This paper presents how acquisition, storage and communication of clinical documents is implemented at the University Hospitals of Geneva. Careful attention has been given to user-interfaces, in order to support complex layouts, spell checking, and templates management with automatic prefilling. A dual architecture has been developed for storage using an entity-attribute-value unified database and a consolidated, patient-centered, layout-respectful file-based storage, providing both representation power and speed of access. This architecture allows a great flexibility for storing a continuum of data types, ranging from simple typed values to complex clinical reports. Finally, communication is entirely based on HTTP-XML internally, and a HL-7 CDA interface V2 is currently studied for external communication. Some of the problems encountered, mostly related to the typology of documents and the ontology of clinical attributes are evoked.
Conservation of Digestive Enzymes (2002)

The traditional understanding is that an entirely new complement of digestive enzymes is secreted by the pancreas into the small intestines with each meal. This is thought to be necessary because, like food itself, these enzymes are degraded during digestion. In this review we discuss experiments that bring this point of view into question. They suggest that digestive enzymes can be absorbed into blood, reaccumulated by the pancreas, and reutilized, instead of being reduced to their constituent amino acids in the intestines. This is called an enteropancreatic circulation of digestive enzymes.
Involvement of a nuclear factor-kappa B-like protein in induction of the macrophage colony-stimulating factor gene by tumor necrosis factor (1991)

The macrophage colony-stimulating factor (M-CSF) is required for the growth and differentiation of mononuclear phagocytes. Previous studies have demonstrated that tumor necrosis factor (TNF) induces transcription of the M-CSF gene in human myeloid cells. The present work examined the effects of TNF on cis-acting elements in the M-CSF promoter. Deleted forms of the M-CSF promoter were linked to the chloramphenicol acetyltransferase (CAT) gene and transfected by electroporation into HL-60 promyelocytic leukemia cells. The results demonstrate that an enhancer responsive to TNF stimulation is located between positions -406 and -344 upstream to the transcription start site. The fragment from positions -419 to -304 was cloned 5′ to the heterologous thymidine kinase (TK) promoter and linked to the CAT gene. Both orientations of this fragment enhanced TK-promoter activity in TNF- treated HL-60 cells. The results of gel mobility shift assays with the - 419 to -304 fragment demonstrate binding of a constitutive nuclear protein. A TNF-inducible protein also bound to this fragment and resulted in a different mobility pattern. Binding of the TNF-induced nuclear protein to the -419 to -304 fragment was inhibited by an oligonucleotide containing the nuclear factor-kappa B (NF-kappa B) consensus sequence. DNA footprinting demonstrated protection of an NF- kappa B binding site at positions -377 to -368. Methylation interference assays showed that the TNF-induced protein made contact points with guanine residues in the same NF-kappa B sequence. Taken together, the findings provide evidence for involvement of an NF-kappa B-like factor in transcriptional regulation of the M-CSF gene.
Effect of CoQ homologues on reactive oxygen generation by mitochondria (2008)

Effect of CoQ compounds (Qs) on reactive oxygen (ROS) generation by mitochondrial complex I was studied using rat liver mitochondria and chemiluminescence probe L012. Kinetic analysis revealed that short chain Qs, such as Q2 and idebenone enhanced ROS generation by mitochondrial NADH oxidase system by a succinate-inhibitable mechanism. Lipid peroxidation in mitochondrial membranes induced by NADH and iron was inhibited by short chain Qs. The inhibitory activity was enhanced by co-oxidation of succinate as determined by chemiluminescence method and by electron spin resonance spectroscopy. These results suggested that the reduced form of short chain Qs inhibited mitochondrial ROS generation and lipid peroxidation.
THE HYPOTENSIVE MECHANISMS OF THE NEW ANTIANGINAL DRUG, N-(2-HYDROXYETHYL)NICOTINAMIDE NITRATE (SG-75) IN BEAGLE DOGS (1981)

The hypotensive mechanisms of N-(2-hydroxyethyl) nicotinamide nitrate (SG-75, Nicorandil) were studied in anesthetized dogs. Intravenous injections of SG-75 (0.03–1 mg/kg) decreased systemic blood pressure (SBP) and increased peripheral (coronary, renal, mesenteric and femoral) blood flow (PBF) dose-dependently. The duration of the PBF increase, however, was much shorter than that of the SBP decrease. When peripheral vascular beds were perfused by means of a pump under a constant perfusion pressure near the SBP, the duration and magnitude of the SBP decrease and the PBF increase were equal. In doses of 0.03–0.3 mg/kg i.v., SG-75 did not significantly affect pulse pressure, heart rate, aortic blood flow, left ventricular pressure (LVP) and LVdP/dt max. Intra-arterial injections of SG-75 (0.003–1 mg) increased coronary, renal, mesenteric and femoral blood flow dose-dependently, without affecting SBP and cardiac function. In heart-lung preparations the drug (0.1–2 mg) did not cause cardio-depression. No hypotensive effect was observed following the administration of SG-75 (3 mg) into the cisterna magna. The results indicate that the hypotensive effect of SG-75 may be due mainly to its peripheral mechanisms, relating to vasodilation.
α2‐Adrenoceptors are not involved in the regulation of striatal glutamate release: Comparison to dopaminergic inhibition (1991)

Striatal slices from the rat were loaded with [3H]glutamate ([3H]Glu) and superfused in order to measure release of radioactivity at rest and during potassium-evoked depolarization. Addition of KCl (22-40 mmol/liter) to the perfusion fluid enhanced the release of tritium in a concentration-dependent manner, and this release was abolished by omission of CaCl2. High-performance liquid chromatography (HPLC) separation coupled with radiochemical detection revealed that 23% and 41% of the tritium efflux detected in the perfusion fluid under resting conditions and during potassium stimulation, respectively, was due to [3H]Glu. At the end of the superfusion about 63% of residual tritium content in the tissue was [3H]Glu. Tritium efflux in response to KCl excess was significantly higher from striatum dissected from 6-hydroxydopamine-pretreated rats. Apomorphine decreased the KCl-evoked release of [3H]Glu, and haloperidol exerted the opposite effect. Yohimbine, which antagonized the decrease of dopa accumulation elicited by apomorphine in NSD-1015 and gamma-butyrolactone-pretreated rat caudate nucleus, also reversed the apomorphine inhibition of the release of [3H]Glu evoked by depolarization. The selective alpha 2-adrenoceptor antagonist CH-38083, however, did not modify the apomorphine inhibition of [3H]Glu release or dopa accumulation, and the alpha 2-adrenoceptor agonist xylazine did not alter tritium efflux from striatum preloaded with [3H]Glu. These findings suggest that release of glutamate (Glu) from the corticostriatal pathway is under tonic control of dopamine released from nigrostriatal neurons, and alpha 2-adrenoceptors are not involved in the regulation of glutamatergic transmission in the rat striatum.(ABSTRACT TRUNCATED AT 250 WORDS)
Pattern of c-Fos expression induced by tail suspension test in the mouse brain (2017)

The tail suspension test (TST) has been widely used as a screening assay for antidepressant drugs. However, the neural substrates underlying the stress response and antidepressant-like effect during the TST remain largely unknown despite the prevalence of this test. In the present study, we used immunohistochemistry to examine alterations in c-Fos expression as a measure of neuronal activity in the mouse brain after acute administration of the antidepressant drugs nortriptyline or escitalopram (or saline as a control) with or without a subsequent TST session. We found that without the TST session, nortriptyline administration enhanced the density of c-Fos-immunoreactive cells in regions of the central extended amygdala, paraventricular hypothalamic nucleus, and relevant regions of the brain stem, whereas escitalopram did not change c-Fos expression in any region. Following the TST in the absence of antidepressant drugs, we observed a significant increase in c-Fos-positive cell density in a number of brain regions within the limbic telencephalon, hypothalamus, and brain stem. We detected a statistically significant interaction using an analysis of variance between the main effects of the drug and stress response in four regions: the infralimbic cortex, lateral septal nucleus (intermediate part), ventrolateral preoptic nucleus, and solitary nucleus. Following the TST, escitalopram but not nortriptyline increased c-Fos-positive cell density in the infralimbic cortex and ventrolateral preoptic nucleus, whereas nortriptyline but not escitalopram increased c-Fos expression in the solitary nucleus. Both antidepressants significantly increased c-Fos expression in the lateral septal nucleus (intermediate part). The present results indicate that neuronal activity increases in septo-hypothalamic regions and related structures, especially the lateral septal nucleus, following administration of drugs producing an antidepressant-like effect in mice subjected to the TST.
Performance and Long-term Durability of Nanostructured Ni Anodes Doped with Transition Metals prepared by Spray Mist Dryer (2009)

Various additives for Ni anodes mixed with ScSZ prepared by spray mist dryer are examined for SOFCs in order to improve their anodic activity and long-term durability. Among the additives examined, it is found that the addition of Mn was highly effective to improve anode activity and sulfur tolerance. In case 5 mol% Mn was added to Ni, at 800 oC and 200 mA/cm2 for 50 % pre-reformed CH4 fuels (S/C = 2.5), the initial cell voltage drop by 5 ppm H2S was ca. 30 mV, which was less than half of the initial cell voltage drop for undoped Ni-cermet anodes. Mn-oxide reacts with NiO during preparation, while Ni metal nanoparticles will be segregated after reduction and Mn-oxide acts as pinning sites to depress grain growth and agglomeration of Ni particles, leading to lower anodic overvoltage and higher sulfur tolerance. Long-term durability up to 3000 hours has been verified.
The SGML handbook (1990)

PART ONE, TUTORIALS: Introduction to generalized markup Basic concepts Additional concepts Link in a nutshell PART TWO, OVERVIEW OF THE STANDARD: Introduction Text processing application SGML application SGML document Processing model Storage model Character sets Markup declaration Conformance PART THREE, SGML ANNOTATED PART FOUR, 8879 ANNEXES APPENDICES INDEX COLOPHON.
An arbitrary two-qubit computation in 23 elementary gates or less (2004)

Quantum circuits currently constitute a dominant model for quantum computation according to M. Nielsen and I. Chuang (2000). Our work addresses the problem of constructing quantum circuits to implement an arbitrary given quantum computation, in the special case of two qubits. We pursue circuits without ancilla qubits and a small number of elementary quantum gates by A. Barenco et al. (1995) and G. Song and A. Klappenecker (2003) as possible. Our lower bound for worst-case optimal two-qubit circuits calls for at least 17 gates: 15 one-qubit rotations and 2 CNOTs. To this end, we constructively prove a worst-case upper bound to 23 elementary gates, of which at most 4 (CNOTs) entail multi-qubit interactions. Our analysis shows that previous known synthesis algorithms, although more general, entail much larger quantum circuits than ours in the special case of two qubits. One such algorithm according to G. Cybenko (2001) has a worst case of 61 gates of which 18 may be CNOTs. Our technique rely on the KAK decomposition from Lie theory as well as the polar and spectral (symmetric Shur) matrix decompositions from numerical analysis. They are related to the canonical decomposition of two-qubit gate with respect to the "magic basis" of phase-shifted Bell states by N. Khaneja et al. (2001) and M. Lewenstein et al. (2001). We extend this decomposition in terms of elementary gates for quantum computation.