gebhart/patrepeval huggingface dataset:
Abrogation of attachment of Infectious Bursal Disease Virus to chicken B cells by treatment of B cells with Soyabean Agglutinin and Wheat Germ Lectin (2008)

Infectious Bursal Disease (IBD) is a viral disease of young chickens with high morbidity and low mortality. The target molecule on B cells for binding of IBD virus (IBDV) is not known. In this study, bursal B cells from chicken aged 6 weeks were treated with either Soyabean Agglutinin (SBA) or Wheat Germ Lectin (WGL) prior to incubation with IBDV. The mean percentages of B cells positive for IBDV binding without and after treatment of B cells with lectins SBA and WGL were 94.48 + 0.47, 88.52 + 0.54 and 88.86 + 0.35, respectively. The differences between the values without and after treatment in case of both the lectins were found to be highly significant (p<0.0001). However, the two lectins did not differ significantly with each other in their effects. ANOVA among the values of the three groups revealed very significant differences (F = 52.778; p = 0.0005) among them. The results suggest that the putative IBDV binding site on B cells may possibly be a lectin binding molecule.
Enrique Fernández, director general de Experis [Entrevista]: "Antes de pensar en retener hay que saber qué talento es el que queremos retener" (2012)

The role of nitric oxide (NO) in the regulation of exocrine secretion was investigated in isolated rat pancreatic acini. NO synthase activity was detected in the extract of acini and purified by ion-exchange and 2',5'-ADP agarose chromatographies. Enzyme activity was determined by conversion of 3H-arginine to 3H-citrulline, by measurement of nitrite (a breakdown product of NO) and by generation of cyclic GMP. Treatment of acini with L-arginine increased nitrite as well as cyclic GMP and amylase release, which were prevented by the nitric oxide synthase inhibitors N-monomethyl-arginine [NMMA] and NG-nitro-L-arginine [NNA]. These nitric oxide inhibitors also blocked carbachol-induced amylase release as well as elevation of acinar cell cyclic GMP. NNA was a potent inhibitor of carbamylcholine-induced amylase release (est. Ki = 2.2 uM). Nitric oxide apparently participates significantly in the overall control of pancreatic acinar cell secretory function.
.ALPHA.-Smooth Muscle Actin-positive Stromal Cells Reactive to Estrogens Surround Endometrial Glands in Rats but not Mice (2005)

In human endometrium, α-smooth muscle actin (α-SMA)-positive stromal cells (SMA-SCs) surround endometrial glands, and the α-SMA expression is regulated by estrogen. The biological significance of these cells remains to be elucidated, and no information is available with regard to their animal counterparts. The present study, therefore, investigated SMA-SCs in the uteri of female Donryu rats and CD-1 mice. SMA-SCs with morphological similarities to those in the human were detected around the endometrial glands in normal cycling rats, but not in mice. Furthermore, the rat SMA-SCs disappeared after ovariectomy but returned with estrogen replacement in a duration-dependent manner, suggesting the regulatory role of estrogens similar to the human situation. Thus, SMA-SCs are present in rats, but not in mice, with characteristics close to their human counterparts. Their biological significance now needs to be elucidated by comparative studies.
Particle-localized AC and DC manipulation and electrokinetics (2009)

Colloidal particles suspended in water respond to direct (DC) or alternating current (AC) fields in a variety of ways, including directional motion along or across the field direction, field-gradient dependent response and induced particle–particle interaction. We review here some of these effects and their applications in new techniques for particle manipulation and assembly, making of novel biomaterials and designing of new self-propelling microdevices. The coupling of the counterionic layer mobility, fluid flows and the resulting particle motion are the basis not only of the classic electrophoretic effects, but also of the recent developments in AC electrohydrodynamics and induced charge electrophoresis of asymmetric particles. We also discuss how dielectrophoresis (particle interaction with external AC field gradients), could be used to manipulate and assemble objects on any size scale. We discuss the interactions leading to the assembly of such structures, ways to simulate the dynamics of the process and the effect of particle size and conductivity on the type of structure obtained. Finally, we demonstrate how an additional level of complexity can be engineered to turn miniature semiconductor diodes into prototypes of self-propelling micromachines and micropumps. The diodes suspended in water propel themselves electro-osmotically when a uniform alternating electric field is applied across the container. Semiconductor diodes embedded in channel walls could serve as distributed microfluidic pumps and mixers powered by a global external field.
The Relevance of Semantic Subtyping (2003)

We compare Meyer and Routley's minimal relevant logic B+ with the recent semantics-based approach to subtyping introduced by Frisch, Castagna and Benzaken in the definition of a type system with intersection and union. We show that – for the functional core of the system – such notion of subtyping, which is defined in purely set-theoretical terms, coincides with the relevant entailment of the logic B+.
Electrochemical affinity biosensors for fast detection of gene-specific methylations with no need for bisulfite and amplification treatments (2018)

This paper describes two different electrochemical affinity biosensing approaches for the simple, fast and bisulfite and PCR-free quantification of 5-methylated cytosines (5-mC) in DNA using the anti-5-mC antibody as biorecognition element. One of the biosensing approaches used the anti-5-mC as capture bioreceptor and a sandwich type immunoassay, while the other one involved the use of a specific DNA probe and the anti-5-mC as a detector bioreceptor of the captured methylated DNA. Both strategies, named for simplicity in the text as immunosensor and DNA sensor, respectively, were implemented on the surface of magnetic microparticles and the transduction was accomplished by amperometry at screen-printed carbon electrodes by means of the hydrogen peroxide/hydroquinone system. The resulting amperometric biosensors demonstrated reproducibility throughout the entire protocol, sensitive determination with no need for using amplification strategies, and competitiveness with the conventional enzyme-linked immunosorbent assay methodology and the few electrochemical biosensors reported so far in terms of simplicity, sensitivity and assay time. The DNA sensor exhibited higher sensitivity and allowed the detection of the gene-specific methylations conversely to the immunosensor, which detected global DNA methylation. In addition, the DNA sensor demonstrated successful applicability for 1 h-analysis of specific methylation in two relevant tumor suppressor genes in spiked biological fluids and in genomic DNA extracted from human glioblastoma cells.
Pulling tension monitoring during the melt impregnation of glass roving (2000)

Abstract The force required to pull a 2400 tex glass roving through a melt impregnation compounding process was studied. Pulling force was continuously measured by suspending the double belt puller in a sling held stationary by a force transducer. Process variables such as roving pulling speed, number of cylindrical pins, pin diameter, and melt temperature were studied using polymide 66 and polypropylene polymers. The results suggest that the tension build‐up in the roving is caused by a combination of two effects: viscous shear stresses in a thin polymer‐rich layer between the roving and the pin, as well as frictional forces caused by roving contact with the pin. A simple mathematical model is developed and used to adequately describe the experimental results.
Adaptive Modeling of Receiver Clock for Meter-level DGPS Vertical Positioning (1995)

A significant improvement in the quality of
GPS-derived vertical position estimates has
been demonstrated with an approach
requiring predictable behavior from the
receiver clock. The approach is based on a
structure inherent in the GPS measurements:
errors in the estimates of vertical position and
clock bias obtained from a snapshot of
pseudorange measurements are highly
correlated. This correlation allows us to
compute improved vertical position estimates,
and provides a basis for integrity monitoring.
The practicality of this approach currently rests
on our ability to model the receiver clock
behavior accurately using the past GPS
measurements.
Results are presented on receiver clock
modeling from laboratory and field tests for a
range of commercial products. Several oven-
controlled crystal oscillators and rubidium
oscillators have been found to offer the
requisite stability, and have provided superior
vertical position estimates in field trials,
including flight tests. Clock-aided navigation
cuts the rms vertical position error by a third to
a half, and provides vertical position estimates
of a quality comparable with that of the
horizontal estimates.
Cognitive changes in the preclinical phase of familial Alzheimer's disease (2007)

Few studies have examined the presence of linguistic deficits in the preclinical phase of Alzheimer's disease (AD). A total of 19 healthy carriers of the E280A presenilin-1 gene mutation in chromosome 14 and 21 noncarrier family members from Antioquia, Colombia, were administered a neurolinguistic evaluation of lexical-semantic processes. Both groups were similar in age, educational level, and gender. Carriers scored significantly lower than noncarriers on naming of famous faces. Cognitive changes in lexical-semantic tasks can be detected before the clinical diagnosis of probable familial AD, and a neurolinguistic evaluation may be a useful tool in the early clinical diagnosis of sporadic AD as well.
Effect of oncogenic virus on muscle differentiation. (1975)

Chick muscle cultures infected with wild-type Rous sarcoma virus form myotubes, but these myotubes vacuolate and by day 6 most have degenerated, leaving only large numbers of transformed mononucleated, replicating cells. Muscle cultures infected with a temperature-sensitive mutant (TS) at permissive temperatures behave as cells infected with wild-type Rous sarcoma virus. TS-infected cells reared for 8 days at nonpermissive temperature form contracting myotubes, plus large numbers of fibroblastic cells. If these cultures are lowered to permissive temperature, within 72 hr the myotubes vacuolate and degenerate, whereas the mononucleated cells transform. If replicating TS-transformed cells after 8 days at permissive temperature are shifted to nonpermissive temperature, within 72 hr many cells fuse and form contracting, post-mitotic myotubes. Creatine kinase (ATP:creatine N-phosphotransferase, EC 2.7.3.2) levels parallel the formation and degeneration of myotubes during these temperature shifts. If the viral transforming gene is expressed in the post-mitotic myotubes it is lethal, whereas it is not lethal if expressed in replicating percursor myogenic cells. The viral gene expression at permissive temperature blocks further myogenesis depending on the position of the cells in the myogenic program. The virus does not cancel the replicating, transformed myogenic cells' commitment to, or position in, the myogenic lineage. When the transforming action of the virus is suppressed, the normal myogenic program resumes.
Local J/sub C/ and microstructures of multilayer Bi-2212 composite tape (2002)

We investigated the local J/sub C/ and microstructures of Bi-2212 multilayer tapes. Multilayer tapes were prepared by wrapping four dip-coated sheets with silver foil. These tapes were fabricated with a melt-solidification method with a Pre-Annealing and Intermediate Rolling (PAIR) process. The local J/sub C/ distribution along the transverse direction of the tapes was determined in a nondestructive manner in which a magnetic field with a steep gradient was applied at 77 K, and the I/sub C/ was measured. The microstructures of the superconducting oxide layers were observed by using an optical micrograph and an SEM micrograph. Bi-2212 superconducting oxide layers existed on silver substrates homogeneously, and the silver/oxide interfaces were almost smooth along the silver substrates. From the J/sub C/-profile, J/sub C/ values at the middle region on the tape were low in comparison with the J/sub C/ values in the edge regions. The depression of the J/sub C/ values around the middle region was due to the overlapping of silver foil and, hence, the inferior microstructure.
Fabrication of Monolayers Containing Internal Molecular Scaffolding:  Effect of Substrate Preparation (1998)

The nanoscale design and fabrication of monolayer assemblies is becoming increasingly important for research areas ranging from adhesion to chemical sensors. The formation of molecular scaffolding within a single molecular layer by linking adjacent molecules provides an important means for the nano- to microscale fabrication of such interfacial assemblies. Unfortunately, key factors in the design and fabrication of these internally linked monolayers are often overlooked due to direct analogy with the often studied n-alkyl monolayer systems. In this investigation, the impact of substrate preparation on the resulting monolayer structure is compared for n-alkyl (C18) and internally linked polydiacetylene monolayer assemblies formed on evaporated, sputtered, and colloidal gold surfaces. Polydiacetylene monolayers are fabricated by the spontaneous assembly of diacetylene-containing disulfides followed by photoinduced polymerization. The resulting polydiacetylene monolayers exhibit systematic variations in the degree of polymerization, alkyl chain crystallinity, advancing contact angle, and electron-transfer inhibition with substrate preparation. By all these measures, both the short- and long-range order of these polymerized monolayers are observed to increase substantially on evaporated gold substrates. In contrast, the n-alkyl-based monolayers formed under identical conditions show minimal structural variation. Moreover, surface pretreatment is demonstrated to have a significant impact on the long-range order for both the n-alkyl and polydiacetylene monolayers. These experimental observations implicate domain size as a significant parameter in the fabrication of polydiacetylene monolayers, while exhibiting little or no impact on the apparent structure of n-alkyl-based monolayer assemblies. Ultimately, the successful fabrication of monolayer structures containing internal molecular scaffolding is made possible by the judicious choice of substrate preparation conditions.
Implementation of all-digital wideband RF frequency synthesizers in 65-nm CMOS technology (2011)

This paper presents two all-digital RF frequency synthesizers implemented in 65-nm CMOS: a digital period frequency synthesizer and an all-digital phase-locked loop. This paper is especially focused on the implementation issues and practical challenges of digital frequency synthesizers for wideband radio systems. Moreover, the paper presents implementations and experimental results of these two frequency synthesizers targeted for cognitive radio spectrum sensing applications.
Silicon-Containing Neurotensin Analogues as Radiopharmaceuticals for NTS1-Positive Tumors Imaging (2020)

Several independent studies have demonstrated the overexpression of NTS<sub>1</sub> in various malignancies, which make this receptor of interest for imaging and therapy. To date, radiolabeled neurotensin analogues suffer from low plasmatic stability and thus insufficient availability for high uptake in tumors. We report the development of <sup>68</sup>Ga-radiolabeled neurotensin analogues with improved radiopharmaceutical properties through the introduction of the silicon-containing amino acid trimethylsilylalanine (TMSAla). Among the series of novel radiolabeled neurotensin analogues, [<sup>68</sup>Ga]<b>Ga-</b>JMV6659 exhibits high hydrophilicity (log <i>D</i><sub>7.4</sub> = -3.41 ± 0.14), affinity in the low nanomolar range toward NTS<sub>1</sub> (<i>K</i><sub>d</sub> = 6.29 ± 1.37 nM), good selectivity (<i>K</i><sub>d</sub> NTS<sub>1</sub>/<i>K</i><sub>d</sub> NTS<sub>2</sub> = 35.9), and high NTS<sub>1</sub>-mediated internalization. It has lower efflux and prolonged plasmatic half-life in human plasma as compared to the reference compound ([<sup>68</sup>Ga]Ga-JMV6661 bearing the minimum active fragment of neurotensin and the same linker and chelate as other analogues). In nude mice bearing HT-29 xenograft, [<sup>68</sup>Ga]Ga-JMV6659 uptake reached 7.8 ± 0.54 %ID/g 2 h post injection. Uptake was decreased to 1.38 ± 0.71 %ID/g with injection of excess of non-radioactive neurotensin. Radiation dose as extrapolated to human was estimated as 2.35 ± 0.6 mSv for a standard injected activity of 100MBq. [<sup>68</sup>Ga]Ga-JMV6659 was identified as a promising lead compound suitable for PET imaging of NTS<sub>1</sub>-expressing tumors.
[A Case of Locally Advanced Rectal Cancer with Abscess and Rectovesical Fistula Curatively Resected Following Preoperative Chemotherapy]. (2017)

A 63-year-old man with bloody stools, anal incompetence, and feeling of fatigue was diagnosed as having a RAS mutanttype rectal cancer with abscess and rectovesical fistula. Computed tomography revealed that the tumor had invaded the seminal vesicle, prostate, and bladder and formed an abscess. In addition, his general condition was poor. Thus, we evaluated the lesion as unresectable. His nutritional status improved, and the infection was controlled after colostomy. Then, we performed chemotherapy with 5-fluorouracil, Leucovorin, and oxaliplatin(FOLFOX)plus bevacizumab. However, after a single course of chemotherapy, the systemic inflammatory reaction was prolonged. Despite treatment of the infection with antibiotics, it was not fully controlled, making it difficult to continue chemotherapy. A new lesion did not appear, but the primary tumor increased in size. Thus, we performed pelvic exenteration. Pathological examination revealed that the tumor was a well-differentiated adenocarcinoma invading the sigmoid colon and bladder. We resected it curatively and administered adjuvant chemotherapy postoperatively. No recurrence was observed during 10 months' follow-up.
Left Atrial Appendage Occlusion Device Embolization (The LAAODE Study): Understanding the Timing and Clinical Consequences from a Worldwide Experience (2021)

LAAODE is common with a reported incidence of 2% in our study. Post-operative device embolization occurred more frequently and was associated with a higher rate of complications than intraoperative device embolizations. Understanding the timings and clinical sequelae of DE can aid physicians with post procedural follow-up and also in the selection of patients for these procedures.
Front Matter: Volume 9702 (2016)

This PDF file contains the front matter associated with SPIE Proceedings Volume 9702, including the Title Page, Copyright information, Table of Contents, Introduction, and the Conference Committee listing.
Phase Separation Prior to Alloying Observed in Vacuum Heating of Hybrid Au/Cu2O Core–Shell Nanoparticles (2016)

The coexistence of decomposition, phase segregation, and alloying behaviors of Au@Cu2O core–shell nanoparticles were found through in situ heating transmission electron microscopy imaging and spectral-analysis techniques. Thermally induced compositional variations (from Cu2O to Cu) were observed to be present in the nanoparticle shells, which was followed by a spontaneous occurrence of Au–Cu alloying. The higher-Cu loading (1:10 Au/Cu) sample displays a clear Cu/Cu2O phase segregation driven by the internal stresses resulting from lattice mismatch. Cu extrusions also occur in this sample after storage in ethanol for 10 days. These in situ observations/findings may help enhance a fundamental understanding of remarkable experimental aspects arising in catalytic processes and other applications as well as provide a valuable reference for testing/refining potential models of hybrid nanoparticles in theoretical calculations.
Phase II study of concurrent cetuximab (C225) plus definitive thoracic radiotherapy (XRT) followed by adjuvant docetaxel in poor prognosis patients with locally advanced non-small cell lung cancer (LA-NSCLC). (2012)

7065 Background: Recursive partitioning analysis has shown that ECOG PS ≥ 2, male gender, or age &gt; 70 are prognostic of poor outcome in LA-NSCLC pts. Concurrent chemoradiotherapy improves survival, but toxicity is concerning in this frail pt cohort. We therefore opened this trial of concurrent definitive-dose XRT (70 Gy in 35 fractions) and C225 (250 mg/m 2 /dose), followed by adjuvant C225 and docetaxel (60 mg/m2 q3weeks x 3 cycles). Methods: Eligible patients had pathologically-proven LA-NSCLC (stage IIA – “dry” IIIB), not surgically resectable. They had ECOG PS 2 OR weight loss ≥5% in 3 months OR age &gt;70. The primary objective was progression-free survival (PFS). Secondary objectives included overall survival (OS) and overall response rate (ORR). Results: From 5/2008 to 11/2010, 32 pts were evaluated for our single-institution, IRB-approved prospective clinical trial. 3 pts were screen-failures and 2 more withdrew consent prior to treatment, leaving 27 evaluable patients. 1 was removed due to poor therapy compliance and 2 were taken off trial due to grade 3 toxicity from the C225 loading dose, but were followed under intent-to-treat analysis. Median follow-up and OS was 10.5 months. Median PFS was 7.8 months. ORR = 59.3%. 8 early/sudden deaths were reported, so the trial closed early: radiation pneumonitis (RP) was the apparent cause in 1 and probably/possibly in 4 others, with insufficient information in 2 additional pts; 1 pt died of failure to thrive. Of the remaining pts, 3 developed grade 3+ RP and 2 had grade 2 RP. Conclusions: Pts enrolled on this trial had improved OS compared with poor-PS historical controls (10.5 vs 6.3 months) and comparable OS compared with good-PS historical controls (10.5 vs 11.9 months) treated with RT (Werner-Wasik M et al. Int J Radiat Oncol Biol Phys. 2000;48:1475-82). However, pulmonary toxicity is a concern. Analysis of RP events is ongoing. Updated results will be presented at the meeting.
Analysis of Amylin Consensus Sequences Suggests That Human Amylin Is Not Optimized to Minimize Amyloid Formation and Provides Clues to Factors That Modulate Amyloidogenicity (2020)

The neuropancreatic polypeptide hormone amylin forms pancreatic islet amyloid in type-2 diabetes. Islet amyloid formation contributes to β-cell death in the disease and to the failure of islet transplants, but the features which influence amylin amyloidogenicity are not understood. We constructed an amino acid sequence alignment of 202 sequences of amylin and used the alignment to design consensus sequences of vertebrate amylins, mammalian amylins, and primate amylins. Amylin is highly conserved, but there are differences between human amylin and each consensus sequence, ranging from one to six substitutions. Biophysical analysis shows that all of the consensus sequences form amyloid but do so more slowly than human amylin in vitro. The rate of amyloid formation by the primate consensus sequence is 3- to 4-fold slower than human amylin; the mammalian consensus sequence is approximately 20- to 25-fold slower, and the vertebrate consensus sequence is approximately 6-fold slower. All of the consensus sequences are moderately less toxic than human amylin toward a cultured β-cell line, with the vertebrate consensus sequence displaying the largest reduction in toxicity of 3- to 4-fold. All of the consensus sequences activate a human amylin receptor and exhibit only modest reductions in activity, ranging from 3- to 4-fold as judged by a cAMP production assay. The analysis argues that there is no strong selective evolutionary pressure to avoid the formation of islet amyloid and provides information relevant to the design of less amyloidogenic amylin variants.