gebhart/patrepeval huggingface dataset:
Hybrid Artificial Bee Colony Algorithm for a Parallel Batching Distributed Flow-Shop Problem With Deteriorating Jobs (2019)

In this article, we propose a hybrid artificial bee colony (ABC) algorithm to solve a parallel batching distributed flow-shop problem (DFSP) with deteriorating jobs. In the considered problem, there are two stages as follows: 1) in the first stage, a DFSP is studied and 2) after the first stage has been completed, each job is transferred and assembled in the second stage, where the parallel batching constraint is investigated. In the two stages, the deteriorating job constraint is considered. In the proposed algorithm, first, two types of problem-specific heuristics are proposed, namely, the batch assignment and the right-shifting heuristics, which can substantially improve the makespan. Next, the encoding and decoding approaches are developed according to the problem constraints and objectives. Five types of local search operators are designed for the distributed flow shop and parallel batching stages. In addition, a novel scout bee heuristic that considers the useful information that is collected by the global and local best solutions is investigated, which can enhance searching performance. Finally, based on several well-known benchmarks and realistic industrial instances and via comprehensive computational comparison and statistical analysis, the highly effective performance of the proposed algorithm is favorably compared against several algorithms in terms of both solution quality and population diversity.
Oral Microbial Ecology and the Role of Salivary Immunoglobulin A (1998)

In the oral cavity, indigenous bacteria are often associated with two major oral diseases, caries and periodontal diseases. These diseases seem to appear following an imbalance in the oral resident microbiota, leading to the emergence of potentially pathogenic bacteria. To define the process involved in caries and periodontal diseases, it is necessary to understand the ecology of the oral cavity and to identify the factors responsible for the transition of the oral microbiota from a commensal to a pathogenic relationship with the host. The regulatory forces influencing the oral ecosystem can be divided into three major categories: host related, microbe related, and external factors. Among host factors, secretory immunoglobulin A (SIgA) constitutes the main specific immune defense mechanism in saliva and may play an important role in the homeostasis of the oral microbiota. Naturally occurring SIgA antibodies that are reactive against a variety of indigenous bacteria are detectable in saliva. These antibodies may control the oral microbiota by reducing the adherence of bacteria to the oral mucosa and teeth. It is thought that protection against bacterial etiologic agents of caries and periodontal diseases could be conferred by the induction of SIgA antibodies via the stimulation of the mucosal immune system. However, elucidation of the role of the SIgA immune system in controlling the oral indigenous microbiota is a prerequisite for the development of effective vaccines against these diseases. The role of SIgA antibodies in the acquisition and the regulation of the indigenous microbiota is still controversial. Our review discusses the importance of SIgA among the multiple factors that control the oral microbiota. It describes the oral ecosystems, the principal factors that may control the oral microbiota, a basic knowledge of the secretory immune system, the biological functions of SIgA, and, finally, experiments related to the role of SIgA in oral microbial ecology.
Interruption of transmembrane signaling as a novel antisecretory strategy to treat enterotoxigenic diarrhea (1999)

Bacteria that produce heat-stable enterotoxins (STs), a leading cause of secretory diarrhea, are a major cause of morbidity and mortality worldwide. ST stimulates guanylyl cyclase C (GCC) and accumulation of intracellular cyclic GMP ([cGMP]i), which opens the cystic fibrosis transmembrane conductance regulator (CFTR)-related chloride channel, triggering intestinal secretion. Although the signaling cascade mediating ST-induced diarrhea is well characterized, antisecretory therapy targeting this pathway has not been developed. 2-ChloroATP (2ClATP) and its cell-permeant precursor, 2-chloroadenosine (2ClAdo), disrupt ST-dependent signaling in intestinal cells. However, whether the ability to disrupt guanylyl cyclase signaling translates into effective antisecretory therapy remains untested. In this study, the efficacy of 2ClAdo to prevent ST-induced water secretion by human intestinal cells was examined. In Caco-2 human intestinal cells, ST increased [cGMP]i, induced a chloride current, and stimulated net basolateral-to-apical water secretion. This effect on chloride current and water secretion was mimicked by the cell-permeant analog of cGMP, 8-bromo-cGMP. Treatment of Caco-2 cells with 2ClAdo prevented ST-induced increases in [cGMP]i, chloride current and water secretion. Inhibition of the downstream consequences of ST-GCC interaction reflects proximal disruption of cGMP production because 8-bromo-cGMP stimulated chloride current and water secretion in 2ClAdo-treated cells. Thus, this study demonstrates that disruption of guanylyl cyclase signaling is an effective strategy for antisecretory therapy and provides the basis for developing mechanism-based treatments for enterotoxigenic diarrhea.
Hydrogen Isotope Effects on Aqueous Electrolyte for Electrochemical Lithium‐Ion Storage (2022)

As two stable hydrogen isotopes, protium and deuterium show magnified isotope effects in physicochemical properties due to the significantly varied atomic masses. In this work, aqueous electrolytes based on heavy water (D<sub>2</sub> O) and light water (H<sub>2</sub> O) were prepared to reveal the electrochemical isotope effects between the hydrogen isotopes. The covalent hydrogen-oxygen bond and intermolecular hydrogen bond in D<sub>2</sub> O are much stronger than those in H<sub>2</sub> O, making them thermodynamically more stable. Compared with the H<sub>2</sub> O-based electrolyte, the D<sub>2</sub> O-based electrolyte shows a broader electrochemical window, a higher percentage of coordinated water and a longer lifetime of hydrogen bond. Because of the above electrochemical isotope effects, the D<sub>2</sub> O-based electrolyte shows high anodic stability against operation of high-voltage layered oxide cathode materials including LiCoO<sub>2</sub> and LiNi<sub>0.8</sub> Co<sub>0.1</sub> Mn<sub>0.1</sub> O<sub>2</sub> , which enables long cycle life and favorable rate performance of aqueous Li-ion batteries.
Improved speed near field communication with rotated QPSK constellation and hidden data transmission (2012)

A quadrature phase shift keying (QPSK) modulation with additional data transmission is proposed to improve throughput for near field communications. The additional data is transmitted by the phase rotation of the constellation.
When Did Mycobacterium tuberculosis Infection First Occur in The New World?: An Important Question with Public Health Implications (1995)

"When Did Mycobacterium tuberculosis Infection First Occur in The New World?: An Important Question with Public Health Implications." American Journal of Respiratory and Critical Care Medicine, 151(4), pp. 1267–1268
High-level synthesis for low power based on network flow method (2003)

We propose an effective algorithm for power optimization in behavioral synthesis. In previous work, it has been shown that several hardware allocation/binding problems for power optimization can be formulated as network flow problems and cand be solved optimally. However, in these formulations, a fixed schedule was assumed. In such a context, one key problem is that given an optimal network flow solution to a hardware allocation/binding problem for a given schedule, how to generate a new optimal network-flow solution rapidly for a local change of the given schedule. To this end, from a comprehensive analysis of the relation between network structure and flow computation, we devise a two-step procedure: Step 1) a max-flow computation step which finds a valid (maximum) flow solution while retaining the previous (maximum flow of minimum cost) solution as much as possible and Step 2) a min-cost computation step which incrementally refines the flow solution obtained in Step 1, using the concept of finding a negative cost cycle in the residual graph for the flow. The proposed algorithm can be applied effectively to several important high-level optimization problems (e.g., allocations/bindings of functional units, registers, buses, and memory ports) when we have the freedom to choose a schedule that will minimize power consumption. Experimental results (for bus synthesis) on benchmark problems show that our designs are 4%-40% more power-efficient over the designs produced by a random-move based solution and a clock-step based optimal solution, which is due to a) exploitation of the effect of scheduling and b) optimal binding for every schedule instance. Furthermore, our algorithm is about 2.6 times faster in run time over the full network flow based (optimal) algorithm, which is due to c) our novel (two-step) mechanism which utilizes the previous flow solution to reduce redundant flow computations.
Measures of stored red blood cell quality (2014)

Blood banking underpins modern medical care, but blood storage, necessary for testing and inventory management, reduces the safety and efficacy of individual units of red blood cells (RBCs). Stored RBCs are damaged by the accumulation of their own waste products, by enzymatic and oxidative injury, and by metabolically programmed cell death. These chemical activities lead to a complex RBC storage lesion that includes haemolysis, reduced in vivo recovery, energy and membrane loss, altered oxygen release, reduced adenosine tri-phosphate and nitric oxide secretion, and shedding of toxic products. These toxic products include lysophospholipids that can cause transfusion-related acute lung injury, free iron that can potentiate infections and cause inflammation, and shed microvesicles that can scavenge nitric oxide and potentiate inflammation and thrombosis. However, most of the obvious negative outcomes of RBC storage are uncommon and appear to be related to exceptionally bad units. Generally, the quality of stored RBCs is highly related to the conditions of storage, so refrigerator temperature, intact bags, residual leucocyte counts and visible haemolysis remain excellent general measures. Specific biochemical measures, such as adenosine 5'-triphosphate (ATP) and 2,3-diphosphoglycerate (DPG) concentrations, calcium and potassium content or lipid breakdown products, require specialized measures that are not widely available, involve destructive testing and generally reflect only a part of the storage lesion. This review describes a number of components of the storage lesion and their measurement and attempts to access the utility of the measures.
Multi-Party Cross-Chain Asset Transfers (2022)

&lt;p&gt;With the growing interest in blockchain technology, researchers and developers in different industries are shifting their attention to creating interoperability mechanisms. Existing mechanisms usually encompass asset exchanges, asset transfers, and general data transfers. However, most of the solutions based on these mechanisms only work for two permissionless blockchains falling short in use cases requiring more complex business relationships. Also, contrary to existing legacy systems, there is little standardization for cross-chain communication. Here we present MP-SATP, a resilient multi-party asset transfer protocol built on top of the Secure Asset Transfer Protocol (SATP). Furthermore, we enhance SATP's crash recovery mechanism that directly influences the reliability and performance of our solution. Using MP-SATP, we show how to perform N-to-N resilient asset transfers in permissioned environments by decoupling them into multiple 1-to-1 asset transfers. Our results demonstrate that the latency of the protocol is driven by the latency of the slowest 1-to-1 session; and how the usage of backup gateways avoid the overhead caused by rollbacks. Enterprise-grade environments such as supply-chain management systems can immediately leverage our solution to perform atomic multi-party asset transfers as shown by our use case.&lt;/p&gt;
Haemodynamic effects of magnesium lithospermate B in rats with renal failure (1992)

Abstract A study was performed to investigate the haemodynamic effects of magnesium lithospermate B in rats with renal failure. Urinary excretion of sodium and potassium was significantly increased by administration of magnesium lithospermate B. Blood pressure was significantly lower in the magnesium lithospermate B‐treated group, compared with the control group. In addition, renal tissue blood flow and cerebral blood flow were significantly higher in the magnesium lithospermate B‐treated group, with significantly reduced renal vascular resistance and cerebral vascular resistance compared with the control group. These results confirm that magnesium lithospermate B reduces renovascular hypertension by improving urinary electrolyte excretion and haemodynamics.
The Imipridone ONC201 Induces Apoptosis and Overcomes Chemotherapy Resistance by Up-Regulation of Bim in Multiple Myeloma (2017)

In multiple myeloma, despite recent improvements offered by new therapies, disease relapse and drug resistance still occur in the majority of patients. Therefore, there is an urgent need for new drugs that can overcome drug resistance and prolong patient survival after failure of standard therapies. The imipridone ONC201 causes downstream inactivation of ERK1/2 signaling and has tumoricidal activity against a variety of tumor types, while its efficacy in preclinical models of myeloma remains unclear. In this study, we treated human myeloma cell lines and patient-derived tumor cells with ONC201. Treatment decreased cellular viability and induced apoptosis in myeloma cell lines, with IC50 values of 1 to 1.5 μM, even in those with high risk features or TP53 loss. ONC201 increased levels of the pro-apoptotic protein Bim in myeloma cells, resulting from decreased phosphorylation of degradation-promoting Bim Ser69 by ERK1/2. In addition, myeloma cell lines made resistant to several standard-of-care agents (by chronic exposure) were equally sensitive to ONC201 as their drug-naïve counterparts, and combinations of ONC201 with proteasome inhibitors had synergistic anti-myeloma activity. Overall, these findings demonstrate that ONC201 kills myeloma cells regardless of resistance to standard-of-care therapies, making it promising for clinical testing in relapsed/refractory myeloma.
Application of Grating Substrate Fabricated by Nanoimprint Lithography to Surface Plasmon Field-Enhanced Fluorescence Microscopy and Study of Its Optimum Structure (2009)

Nanoimprint lithography (NIL) has recently been expected to be applied in the field of nanobiology. Substrates with a subwavelength grating pattern covered with metal layers can provide grating-coupled surface plasmon resonance (GC-SPR) under suitable condition. The GC-SPR field can selectively excite a fluorescent dye bound to the substrate and its fluorescence can be enhanced. In our earlier work, using a glass substrate with a grating fabricated by photolithography and dry etching, fluorescence images of labeled cells were taken with high sensitivity under a fluorescence microscope. However, this fabrication process requires a great deal of time. The replication of the subwavelength grating pattern on a polymer film by thermal NIL has an advantage in fabrication process economy. In this study, a grating substrate fabricated by NIL was applied to fluorescence microscopic observation based on GC-SPR and it provided more than six-times enhanced fluorescence images.
Effect of Matrix-Modulating Enzymes on the Cellular Uptake of Magnetic Nanoparticles and on Magnetic Hyperthermia Treatment of Pancreatic Cancer Models In Vivo (2021)

Magnetic hyperthermia can cause localized thermal eradication of several solid cancers. However, a localized and homogenous deposition of high concentrations of magnetic nanomaterials into the tumor stroma and tumor cells is mostly required. Poorly responsive cancers such as the pancreatic adenocarcinomas are hallmarked by a rigid stroma and poor perfusion to therapeutics and nanomaterials. Hence, approaches that enhance the infiltration of magnetic nanofluids into the tumor stroma convey potentials to improve thermal tumor therapy. We studied the influence of the matrix-modulating enzymes hyaluronidase and collagenase on the uptake of magnetic nanoparticles by pancreatic cancer cells and 3D spheroids thereof, and the overall impact on magnetic heating and cell death. Furthermore, we validated the effect of hyaluronidase on magnetic hyperthermia treatment of heterotopic pancreatic cancer models in mice. Treatment of cultured cells with the enzymes caused higher uptake of magnetic nanoparticles (MNP) as compared to nontreated cells. For example, hyaluronidase caused a 28% increase in iron deposits per cell. Consequently, the thermal doses (cumulative equivalent minutes at 43 °C, CEM43) increased by 15-23% as compared to heat dose achieved for cells treated with magnetic hyperthermia without using enzymes. Likewise, heat-induced cell death increased. In in vivo studies, hyaluronidase-enhanced infiltration and distribution of the nanoparticles in the tumors resulted in moderate heating levels (CEM43 of 128 min as compared to 479 min) and a slower, but persistent decrease in tumor volumes over time after treatment, as compared to comparable treatment without hyaluronidase. The results indicate that hyaluronidase, in particular, improves the infiltration of magnetic nanoparticles into pancreatic cancer models, impacts their thermal treatment and cell depletion, and hence, will contribute immensely in the fight against pancreatic and many other adenocarcinomas.
Why Does Space Feel the Way it Does? Towards a Principled Account of Spatial Experience (2019)

There must be a reason why an experience feels the way it does. A good place to begin addressing this question is spatial experience, because it may be more penetrable by introspection than other qualities of consciousness such as color or pain. Moreover, much of experience is spatial, from that of our body to the visual world, which appears as if painted on an extended canvas in front of our eyes. Because it is ‘right there’, we usually take space for granted and overlook its qualitative properties. However, we should realize that a great number of phenomenal distinctions and relations are required for the canvas of space to feel ‘extended’. Here we argue that, to be experienced as extended, the canvas of space must be composed of countless spots, here and there, small and large, and these spots must be related to each other in a characteristic manner through connection, fusion, and inclusion. Other aspects of the structure of spatial experience follow from extendedness: every spot can be experienced as enclosing a particular region, with its particular location, size, boundary, and distance from other spots. We then propose an account of the phenomenal properties of spatial experiences based on integrated information theory (IIT). The theory provides a principled approach for characterizing both the quantity and quality of experience by unfolding the cause-effect structure of a physical substrate. Specifically, we show that a simple simulated substrate of units connected in a grid-like manner yields a cause-effect structure whose properties can account for the main properties of spatial experience. These results uphold the hypothesis that our experience of space is supported by brain areas whose units are linked by a grid-like connectivity. They also predict that changes in connectivity, even in the absence of changes in activity, should lead to a warping of experienced space. To the extent that this approach provides an initial account of phenomenal space, it may also serve as a starting point for investigating other aspects of the quality of experience and their physical correspondents.
A Revised Tangible Employment Action Analysis: Just What is an Undesirable Reassignment? (2006)

Introduction 386 I. Background 388 A. The Emergence of Sexual Harassment in Employment Discrimination 388 B. Developing the Law of Sexual Harassment 389 C. Reviewing the Inconsistencies in Employer Liability for Supervisor Sexual Harassment 390 D. Ellerth, Faragher and Suders, and the Tangible Employment Action Distinction 391 II. Defining “Tangible Employment Action”: Looking at Courts’ Mistaken Interpretation of “Undesirable Reassignment” 393 A. Courts Mistakenly Search for an “Adverse” Employment Action and Rely on Misleading Cases When Determining Whether an Employee Has Suffered a Tangible Employment Action 394 B. Though the Supreme Court Has Directed Otherwise, Courts Still Concentrate on Finding an Economic Harm..399 III. Changing the Way Courts Interpret “Undesirable Reassignment” in Determining Employer Liability 401 A. The Supreme Court’s Main Objective: Finding an Official Act of the Enterprise 401 B. Employing an Objective Standard: What Would the Reasonable Person Do? 404
Disambiguating biomedical acronyms using EMIM (2011)

Expanding a query with acronyms or their corresponding 'long-forms' has not been shown to provide consistent improvements in the biomedical IR literature. The major open issue with expanding acronyms in a query is their inherent ambiguity, as an acronym can refer to multiple long-forms. At the same time, a long-form identified in a query can be expanded with its acronym(s); however, some of these may be also ambiguous and lead to poor retrieval performance. In this work, we propose the use of the EMIM (Expected Mutual Information Measure) between a long-form and its abbreviated acronym to measure ambiguity. We experiment with expanding both acronyms and long-forms identified in the queries from the adhoc task of the TREC 2004 Genomics track. Our preliminary analysis shows the potential of both acronym and long-form expansions for biomedical IR.
Differences in initial electrocardiographic findings between ST-elevation myocardial infarction due to left main trunk and left anterior descending artery lesions (2019)

A large reciprocal ST-segment depression in inferior leads and ST-segment depression in lead V5 are useful ECG findings allowing determination of STEMI due to an LMT lesion.