The Association between the Myelodysplastic Syndromes and Crohn Disease (1992)

Brief Reports15 October 1992The Association between the Myelodysplastic Syndromes and Crohn DiseaseCharis Eng, MD, PhD, Francis A. Farraye, MD, Lawrence N. Shulman, MD, Mark A. Peppercorn, MD, Celeste M. Krauss, MD, Jean M. Connors, MD, Richard M. Stone, MDCharis Eng, MD, PhD, Francis A. Farraye, MD, Lawrence N. Shulman, MD, Mark A. Peppercorn, MD, Celeste M. Krauss, MD, Jean M. Connors, MD, Richard M. Stone, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-8-661 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe myelodysplastic syndromes are a heterogeneous group of bone marrow stem-cell disorders characterized by peripheral cytopenias and hypercellular dysplastic bone marrows (1, 2). The myelodysplastic syndromes, as defined in the French-American-British classification (2), include refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia. Crohn disease, an inflammatory bowel disease, is characterized by specific pathologic and endoscopic gastrointestinal mucosal findings; these include chronic inflammation, noncaseating granulomas, skip lesions, and aphthous ulcerations (3). Unlike the frequent occurrence of clonal chromosomal abnormalities in the bone marrow cells of patients...References1. ListGarewalSandberg AHA. The myelodysplastic syndromes: biology and implications for management. J Clin Oncol. 1990;8:1424-41. CrossrefMedlineGoogle Scholar2. BennettCatovskyDanielFlandrinGaltonGralnick JDMGDH. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol. 1982;51:189-99. CrossrefMedlineGoogle Scholar3. Podolsky D. Inflammatory bowel disease. N Engl J Med. 1991;325:928-37, 1008-16. CrossrefMedlineGoogle Scholar4. KonstantinovaNedkova-Bratanowa BN. Chromosomal aberrations in patients with ulcerohemorrhagic colitis. Digestion. 1969;2:329-37. CrossrefMedlineGoogle Scholar5. GreensteinGennusoSacharHeimannSmithJanowitz ARDTHH. Extraintestinal cancers in inflammatory bowel disease. Cancer. 1985;56:2914-21. CrossrefMedlineGoogle Scholar6. Mir MadjlessiFarmerWeick SRJ. Inflammatory bowel disease and leukemia. Dig Dis Sci. 1986;31:1025-31. CrossrefMedlineGoogle Scholar7. GreenShuttleworthBowenBentley ADDD. Cutaneous vasculitis in patients with myelodysplasia. Br J Haematol. 1990;74:364-70. CrossrefMedlineGoogle Scholar8. PomeroyOkenRydellFilice CMRG. Infection in the myelodysplastic syndromes. Am J Med. 1991;90:338-44. CrossrefMedlineGoogle Scholar9. Mitelman F. Catalog of Chromosome Aberrations in Cancer. 2d edition. New York: Alan R. Liss, Inc.; 1985:538. Google Scholar10. McKusick V. Mendelian Inheritance in Man: Catalogs of Autosomal Dominant, Autosomal Recessive, and X-linked Phenotypes. 8th edition. Baltimore, Maryland: The Johns Hopkins University Press; 1988: xcviii. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Dana-Farber Cancer Institute, Brigham and Women's Hospital, Beth Israel Hospital, Harvard Community Health Plan, and Harvard Medical School, Boston, Massachusetts. For current author addresses, see end of text. 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