gebhart/patrepeval huggingface dataset:
Two Decades of Full-Depth Current Velocity Observations From a Moored Observatory in the Central Equatorial Atlantic at 0°N, 23°W (2022)

© The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Tuchen, F., Brandt, P., Hahn, J., Hummels, R., Krahmann, G., Bourlès, B., Provost, C., McPhaden, M., &amp; Toole, J. Two decades of full-depth current velocity observations from a moored observatory in the central equatorial Atlantic at 0°N, 23°W. Frontiers in Marine Science, 9, (2022): 910979, https://doi.org/10.3389/fmars.2022.910979.
Integration by design (2003)

As goes history, so goes research: this year, activity in areas of retrovirus research related only indirectly have provoked events that are notable when considered together. Last summer it was reported that a patient in one X-linked severe combined immunodeficiency retroviral vector gene therapy trial had developed leukemia. Now disquietingly, there has been a second such event, and a third patient is reported to have a vector insertion near the same gene (LMO2) as observed in the other two individuals (1). Meanwhile, in a basic research laboratory, experiments have moved us another step closer to understanding the mechanics of insertion specificity for retrovirus-type integrases (IN). As reported in this issue of PNAS, investigators have produced active retroviruslike elements with synthetic insertion specificities (2). Dan Voytas and colleagues at Iowa State University (Ames) study the Saccharomyces long terminal repeat (LTR)-retrotransposon Ty5, which targets heterochromatic regions (3). Now, in an elegant adaptation of the two-hybrid system, the 6-aa Ty5 targeting domain (TD) was exchanged for two heterologous domains shown to mediate interaction of their respective proteins with protein partners. When domains from those partners were produced fused to the LexA DNA-binding domain, targeting to LexA-binding sites was observed. Although integration specificity in the system was by no means absolute, these results are of interest to genetic engineers and future gene therapists.
Determination of Indaziflam and its metabolite residues in black grapes (2017)

A simple and inexpensive method was developed using liquid - liquid extraction, together with high performance liquid chromatographic method with UV detection for determination of indaziflam and its metabolite (diamino triazine) residues in black grapes. The method was validated using fruit samples spiked with indaziflam and its metabolite (diamino triazine) at different fortification levels (0.05 and 0.5 µg/g). Average recoveries (using each concentration six replicates) ranged 84-97%, with relative standard deviations less than 3%, calibration solutions concentration in the range 0.05-5.0 µg/mL and limit of detection (LOD) and limit of quantification (LOQ) were 0.05µg/g and 0.02µg/g respectively. Finally the fruit residue samples were analyzed by HPLC.
A fast nonlinear method for parametric imaging of myocardial perfusion by dynamic (13)N-ammonia PET. (2001)

The statistical performance of NRE is competitive with WNLR and superior to Patlak analysis for parametric imaging of myocardial perfusion. NRE is a fast nonlinear alternative to Patlak analysis and other fast linearizing methods for parametric imaging. NRE should be applicable to many other tracers and tracer kinetic models.
Peeling force for an electrostatically charged sheet on a grounded surface (1995)

This paper examines the force required to peel an electrostatically-charged, insulated sheet from direct contact with a ground plane. The problem has its origins in our work on the electrostatics of parachutes but may also be applied to the handling of paper and polymer sheets, insulating textile webs, and thin sheets of tissue-like paper. Experimental peeling force measurements are compared to the forces computed from both a numerically simulated discrete charge model and a simpler analytical model based on large rectangular charge distributions oriented at right angles to the ground plane.
Characterization of fracture mechanisms occurring in vivo in growing rods: how can it help in clinical practice? (2019)

Study design: X-rays and fracture surface analysis of seven growing rods in three patients with severe early onset scoliosis. Objective: (i) Determination of fracture mechanisms in Ti-6Al-4V alloy, Ti Cp 2 and Co-Cr alloy rods. (ii) Investigation of the factors of complication and of strategies to reduce risk of rod fracture. Summary of Background Data: Growing rod fracture is a complication of fusionless surgeries in EOS. Only few studies explored fracture mechanisms and impact on clinical practice is unclear. Methods: Seven rods from three patients treated for EOS were characterized by preoperative, pre-fracture X-rays and after-fracture X-rays. Fracture surface analysis was performed using Scanning Electron Microscopy (SEM). Results: SEM fractography analysis revealed similar features, independent of rod composition and diameter. Fracture is the result of low-cycle fatigue, caused by repeated bending action in anteroposterior direction. This bending moment results from forces aligned parallel to rod axis due to scoliotic curve correction and gravity, and forces acting perpendicular due to bending movement of the spine. Multiple initiation sites were detected. Conclusion: Strategies to minimize fracture events imply adaptations of material properties and geometry to patient morphology, scoliosis characteristics, including sagittal alignment, and spine behavior.
Satoshi Nakamoto and the Origins of Bitcoin -- The Profile of a 1-in-a-Billion Genius (2022)

The mystery about the ingenious creator of Bitcoin concealing behind the pseudonym Satoshi Nakamoto has been fascinating the global public for more than a decade. Suddenly jumping out of the dark in 2008, this persona hurled the decentralized electronic cash system "Bitcoin", which has reached a peak market capitalization in the region of 1 trillion USD. In a purposely agnostic, and meticulous "lea-ving no stone unturned" approach, this study presents new hard facts, which evidently slipped through Satoshi Nakamoto's elaborate privacy shield, and derives meaningful pointers that are primarily inferred from Bitcoin's whitepaper, its blockchain parameters, and data that were widely up to his discretion. This ample stack of established and novel evidence is systematically categorized, analyzed, and then connected to its related, real-world ambient, like relevant locations and happenings in the past, and at the time. Evidence compounds towards a substantial role of the Benelux cryptography ecosystem, with strong transatlantic links, in the creation of Bitcoin. A consistent biography, a psychogram, and gripping story of an ingenious, multi-talented, autodidactic, reticent, and capricious polymath transpire, which are absolutely unique from a history of science and technology perspective. A cohort of previously fielded and best matches emerging from the investigations are probed against an unprecedently restrictive, multi-stage exclusion filter, which can, with maximum certainty, rule out most "Satoshi Nakamoto" candidates, while some of them remain to be confirmed. With this article, you will be able to decide who is not, or highly unlikely to be Satoshi Nakamoto, be equipped with an ample stack of systematically categorized evidence and efficient methodologies to find suitable candidates, and can possibly unveil the real identity of the creator of Bitcoin - if you want.
Electronic Number Plate Generation for Performance Evaluation (2022)

The authors have been involved in real world analysis of Automatic Number Plate Recognition (ANPR) data and systems particularly for law enforcement applications. As a result of such work with Law Enforcement Agencies, contributions have been made to the revision of the British Standards for ANPR. This led to the research team developing performance evaluation measures from an end-to-end system perspective. One such measure was the generation of synthetic image datasets suitable for ANPR performance evaluation. The prime requirement for any ANPR system is data accuracy. This paper reports the initial work and progress made using defined synthetic images to test and assess ANPR engines using a structured methodology.
Particle simulations of ion cloud in a magnetic field (1998)

This work describes a 3D time-dependent particle simulation algorithm used to model the electrodynamics of ion clouds in magnetic fields. The algorithm includes step-wise sequential stages of field evaluation, particle push, and boundary detection. Composite fields due to the ion cloud are computed by superimposing solutions for discrete point sources, together with the use of ground plane and image plane symmetries. A second-order modified Euler predictor-corrector method is used for integration of the equations of motion. Results are presented for an ion cloud under the influence of a bias E-field and the B-field from a magnetized spherical carrier bead used in laser printing applications. We consider cases with the dipole axis oriented parallel and perpendicular to the direction of cloud motion.
Novel Example-Based Method for Super-Resolution and Denoising of Medical Images (2014)

In this paper, we propose a novel example-based method for denoising and super-resolution of medical images. The objective is to estimate a high-resolution image from a single noisy low-resolution image, with the help of a given database of high and low-resolution image patch pairs. Denoising and super-resolution in this paper is performed on each image patch. For each given input low-resolution patch, its high-resolution version is estimated based on finding a nonnegative sparse linear representation of the input patch over the low-resolution patches from the database, where the coefficients of the representation strongly depend on the similarity between the input patch and the sample patches in the database. The problem of finding the nonnegative sparse linear representation is modeled as a nonnegative quadratic programming problem. The proposed method is especially useful for the case of noise-corrupted and low-resolution image. Experimental results show that the proposed method outperforms other state-of-the-art super-resolution methods while effectively removing noise.
System level analysis of fast, per-core DVFS using on-chip switching regulators (2008)

Portable, embedded systems place ever-increasing demands on high-performance, low-power microprocessor design. Dynamic voltage and frequency scaling (DVFS) is a well-known technique to reduce energy in digital systems, but the effectiveness of DVFS is hampered by slow voltage transitions that occur on the order of tens of microseconds. In addition, the recent trend towards chip-multiprocessors (CMP) executing multi-threaded workloads with heterogeneous behavior motivates the need for per-core DVFS control mechanisms. Voltage regulators that are integrated onto the same chip as the microprocessor core provide the benefit of both nanosecond-scale voltage switching and per-core voltage control. We show that these characteristics provide significant energy-saving opportunities compared to traditional off-chip regulators. However, the implementation of on-chip regulators presents many challenges including regulator efficiency and output voltage transient characteristics, which are significantly impacted by the system-level application of the regulator. In this paper, we describe and model these costs, and perform a comprehensive analysis of a CMP system with on-chip integrated regulators. We conclude that on-chip regulators can significantly improve DVFS effectiveness and lead to overall system energy savings in a CMP, but architects must carefully account for overheads and costs when designing next-generation DVFS systems and algorithms.
Bioluminescent response of the dinoflagellate Lingulodinium polyedrum to developing flow: Tuning of sensitivity and the role of desensitization in controlling a defensive behavior of a planktonic cell (2005)

Dinoflagellate bioluminescence is believed to serve a defensive function, decreasing grazing at night. Previous characterization of bioluminescence stimulated by fully developed flows might have underestimated the true sensitivity of bioluminescence by not observing the initial response. Also, it has been suggested that bioluminescence may be more sensitive to time-varying flow than to constant flow conditions. We used developing laminar Couette flow to characterize the sensitivity of the initial bioluminescent response of the dinoflagellate Lingulodinium polyedrum in time-varying flow. Both the absolute sensitivity (threshold) and dynamic sensitivity were consistent with that determined previously in fully developed flows, although there were differences between different cultured isolates of the same species and between those isolates and cells harvested from a unialgal bloom of the same species. When the rate of increase of shear was varied while keeping the maximum shear level similar, the threshold was independent of the rate of increase of shear. Surprisingly, the integrated bioluminescence was strongly dependent on the rate of increase of shear. The mechanism behind the preferential response to rapidly increasing shear was determined to be desensitization. Desensitization may influence which naturally occurring flows strongly stimulate bioluminescence either by allowing cells to avoid producing a primary response in certain slowly changing flows or, more generally, to avoid the cost of repeated stimulation when entrained in environmental flows containing above-threshold shears.
Comparison between Schottky Diodes with Oxide Ramp Termination on Silicon Carbide and Diamond (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
The kinetic profile and clinical implication of SCC-Ag in squamous cervical cancer patients undergoing radical hysterectomy using the Simoa assay: a prospective observational study (2020)

The Simoa SCC-Ag prototype was established for clinical settings. The SCC-Ag levels were higher in patients with risk factors, whereas the kinetic trend of SCC-Ag might be mainly affected by postoperative adjuvant therapy. These data indicate that the SCC-Ag level might be a good predictor for the status of cervical cancer, including disease aggressiveness and treatment response.
Synthesis and characterization of monometallic and bimetallic mixed-ligand complexes of iron(II) containing 2,2'-bipyrimidine or 2,3-bis(2-pyridyl)pyrazine (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of monometallic and bimetallic mixed-ligand complexes of iron(II) containing 2,2'-bipyrimidine or 2,3-bis(2-pyridyl)pyrazineKaren J. Brewer, W. Rorer Murphy Jr., and John D. PetersenCite this: Inorg. Chem. 1987, 26, 20, 3376–3379Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/ic00267a032https://doi.org/10.1021/ic00267a032research-articleACS PublicationsRequest reuse permissionsArticle Views371Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optimal registration of object views using range data (1997)

This paper deals with robust registration of object views in the presence of uncertainties and noise in depth data. Errors in registration of multiple views of a 3D object severely affect view integration during automatic construction of object models. We derive a minimum variance estimator (MVE) for computing the view transformation parameters accurately from range data of two views of a 3D object. The results of our experiments show that view transformation estimates obtained using MVE are significantly more accurate than those computed with an unweighted error criterion for registration.
Fundamentals of Fuel Cells (2009)

Fundamentals of fuel cells including polymer electrolyte fuel cell (PEFC), phosphoric acid fuel cell (PAFC), alkaline fuel cell (AFC), molten carbonate fuel cell (MCFC) and solid oxide fuel cell (SOFC), are presented. Three types of overpotential, activation overpotential, ohmic overpotential and concentration overpotential, are described. Polarization curves in PEFC and SOFC are also presented for better understanding of dominant factors that determine overall cell performance.
Simultaneous detection of E. coli K12 and S. aureus Using a Continuous Flow Multijunction Biosensor (2016)

Rapid detection and identification of potentially harmful bacteria is ideal for food manufacturers to prevent foodborne illness outbreaks. Continuous monitoring method of foodborne pathogens levels and trends in food gives real-time results. Therefore, the objectives of this study were to fabricate and characterize the continuous flow multijunction biosensor for simultaneous detection of Escherichia coli K12 and Staphylococcus aureus. Junction biosensors were fabricated using gold plated tungsten wires coated with polyethylenimine and single walled carbon nanotubes. Each junction was functionalized with streptavidin and biotinylated antibodies specific to E. coli K12 and S. aureus. Then, single or 2 biosensors for each targeted analyte were connected to tubing, perpendicular to the flow direction. Pure serial diluted samples of E. coli K12 and S. aureus and microbial cocktail samples were continuously pumped at a 0.0167 mL/s into the detection zone. Changes in the electric current by biorecognition reactions between antibody and antigens were calculated. The developed junction sensor coupled with the fluidic channel showed the enhancement of the electric signal responses for detection of E. coli K12, compared to the stationary sensor. A linear regression was observed for both the E. coli and S. aureus functionalized array sensors in the detection range of 10(2) to 10(5) CFU/mL. Multiplexed detection of bacteria at the sensing levels as low as 10(2) CFU/mL for E. coli K12 and S. aureus was achieved within 2 min. Therefore, the continuous flow multijunction biosensor shows potential for rapid and continuous multiplexed detection of foodborne pathogens.
AUTOMATIC ACTIVE CONTOURS PROPAGATION IN A SEQUENCE OF MEDICAL IMAGES (2006)

In this paper we present a new algorithm to track an organ in a sequence of medical images in order to achieve a 3D reconstruction. The automatic method that we propose allows the tracking of the external contour of the anatomical organ in all the sequence from one contour initialized by the user on the first image. The required operations for our tracking method are the region-based active contours segmentation. The objects localization with dynamic prediction of displacements is based on the level-set functions and the definition of the region of interest for the robust local estimation of the image model. An application of this method is the 3D reconstruction of abdominal aorta.
An Investigation of Single-Event Transients in C-SiGe HBT on SOI Current Mirror Circuits (2014)

The single-event effect sensitivity of three different commonly employed current mirror circuits, as well as an unconventional inverse-mode current mirror, all implemented in C-SiGe (NPN + PNP) HBT on SOI technology are investigated. Comparisons of the measured data of the basic NPN and PNP current mirror circuits show higher single-event radiation tolerance of PNP SiGe HBTs compared with NPN SiGe HBTs. The concept of utilizing inverse-mode SiGe HBTs in current mirror circuits is investigated. Measurement results validate the feasibility of employing inverse-mode PNP SiGe HBTs in current mirrors and show an excellent resilience against ion-strikes. Full 3-D NanoTCAD models of the SiGe HBTs are developed and used in mixed-mode TCAD simulations (within Cadence) to validate the measurement results. Finally, based on the measurement data and analysis of the four current mirrors, some practical suggestions and observations are offered for operation of such circuits in extreme environments.
Cancer Immunotherapy in Diffuse Large B-Cell Lymphoma (2018)

Remarkable progress has been made in the field of cancer immunotherapy in the past few years. Immunotherapy has become a standard treatment option for patients with various cancers, including melanoma, lymphoma, and carcinomas of the lungs, kidneys, bladder, and head and neck. Promising immunotherapy approaches, such as chimeric antigen receptor (CAR) T cell therapy and therapeutic blockade of immune checkpoints, in particular cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 pathway (PD-1/PD-L1), have boosted the development of new therapeutic regimens for patients with cancer. Immunotherapeutic strategies for diffuse large B-cell lymphoma (DLBCL) include monoclonal anti-CD20 antibody (rituximab), monoclonal anti-PD-1 antibodies (nivolumab and pembrolizumab), monoclonal anti-PD-L1 antibodies (avelumab, durvalumab, and atezolizumab) and chimeric antigen receptor (CAR) T cell therapy. In this review, we outline the latest highlights and progress in using immunotherapy to treat patients with DLBCL, with a focus on the therapeutic blockade of PD-1/PD-L1 and CAR T cell therapy in DLBCL. We also discuss current clinical trials of PD-1/PD-L1 and CAR T cell therapy and review the challenges and opportunities of using immunotherapy for the treatment of DLBCL.