gebhart/patrepeval huggingface dataset:
Experimental and Numerical Investigations of Microcarrier Motions in Simulated Microgravity (1998)

Abstract We are interested in studying the cell/microcarrier motions within the NASA rotating bioreactor system, with the eventual goal of using this description to understand the attachment of cells on microcarriers and the assembly of these cell/bead constructs into three dimensional tissue. In this study, we used both experimental imaging tools and numerical analysis to study the motions of typical microcarrier beads used in the High Aspect Ratio Vessel (HARV). Experimental studies demonstrate that physical properties of the microcarrier beads affect directly the primary radial motion of these particles, and also show that these beads interact and aggregate with each other over time. Numerical analyses using the appropriate governing equations and a Runga-Kutta solution method show that computed results agree with experimental observations on both primary and secondary particle trajectories. From the numerical analysis, we develop an analytical description of a typical particle trajectory in the laboratory frame and develop an experimental apparatus to track a single particle temporally in the bioreactor. Results from this study provide insight into the motion and aggregation of particles in the rotary culture bioreactors over time, and can lead to a better control of the bioreactor mechanical environment.
Antimicrobial susceptibility of Propionibacterium acnes isolated from acne vulgaris. (1999)

Systemic and topical antimicrobial treatment for acne vulgaris remains the mainstay method of therapy in Japan. Strains of Propionibacterium acnes (P. acnes) resistant to erythromycin (EM), clindamycin (CLDM), tetracycline (TC), doxycycline (DOXY) and minocycline (MINO) have been reported. The aim of the present study was to examine the antimicrobial susceptibility to 10 currently used antimicrobial agents of 50 strains of P. acnes isolated from acne lesions and identified using a Rap ID ANA II panel. Minimum inhibitory concentrations (MIC) were determined by the agar dilution method according to the criteria of the Japan Society of Chemotherapy. EM, ampicillin (ABPC), and CLDM were the most potent drugs, followed by MINO, nadifloxacin (NDFX), cephalexin (CEX), DOXY, ofloxacin (OFLX), and TC. In terms of the MIC80, EM and ABPC were the most potent, followed by CLDM, NDFX, MINO, CEX, DOXY, OFLX, TC and gentamycin (GM). Although most of the strains used were susceptible to the antimicrobial agents tested, strains of P. acnes resistant (MIC 12.5 mug/ml) to EM (4%), CLDM (4%), DOXY (2%) and TC (2%) were observed. In this study, no strains of P. acnes resistant to MINO were seen, suggesting that oral MINO is the most useful treatment for acne vulgaris with minimal risk of bacterial resistance.
Spin transport properties of n-polyacene molecules (n = 1–15) connected to Ni surface electrodes: Theoretical analysis (2014)

Using non-equilibrium Green function formalism in conjunction with density functional theory, we explore the spin-polarized transport characteristics of several planar n-acene molecules suspended between two semi-infinite Ni electrodes via the thiol group. We examine the spin-dependence transport on Ni-n-acenes-Ni junctions, while the number of fused benzene rings varies between 1 and 15. Intriguingly, the induced magnetic moments of small acene molecules are higher than that of longer acene rings. The augmentation of fused benzene rings affects both the magnetic and transport features, such as the transmission function and conductance owing to their coupling to the Ni surface contacts via the anchoring group. The interplay between the spin-polarized transport properties, structural configuration and molecular electronic is a fortiori essential in these attractive molecular devices. Thus, this can conduct to the engineering of the electron spin transport in atomistic and molecular junctions. These prominent molecules convincingly infer that the molecular spin valves can conduct to thriving molecular devices.
Structure of thamnosin. Novel dimeric coumarin system (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of thamnosin. Novel dimeric coumarin systemJames P. Kutney, Tadanobu Inaba, and David L. DreyerCite this: J. Am. Chem. Soc. 1968, 90, 3, 813–814Publication Date (Print):January 1, 1968Publication History Published online1 May 2002Published inissue 1 January 1968https://pubs.acs.org/doi/10.1021/ja01005a060https://doi.org/10.1021/ja01005a060research-articleACS PublicationsRequest reuse permissionsArticle Views119Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
T‐cell development: an extrathymic perspective (2006)

The lymph nodes (LNs) harbor a cryptic T-lymphopoietic pathway that is dramatically amplified by oncostatin M (OM). OM-transgenic mice generate massive amounts of T lymphocytes in the absence of Lin(-)c-Kit(hi)IL-7Ralpha- lymphoid progenitors and of reticular epithelial cells. Extrathymic T cells that develop along the OM-dependent LN pathway originate from Lin(-)c-Kit(lo)IL-7Ralpha+ lymphoid progenitors and are different from classic T cells in terms of turnover kinetics and function. Positive selection does not obey the same rules in the thymus and the LNs, where positive selection of developing T cells is supported primarily by epithelial and hematopoietic cells, respectively. Extrathymic T cells undergo enhanced homeostatic proliferation and thereby acquire some properties of memory T cells. Following antigen encounter, extrathymic T-cells initiate proliferation and cytokine secretion more readily than classic T cells, but their accumulation is limited by an exquisite susceptibility to apoptosis. Studies on in vitro and in vivo extrathymic T-cell development have yielded novel insights into the essence of a primary T-lymphoid organ. Furthermore, comparison of the thymic and OM-dependent extrathymic pathways shows how the division of labor between primary and secondary lymphoid organs influences the repertoire and homeostasis of T lymphocytes.
Operationalizing privacy compliance for cloud-hosted sharing of healthcare data (2018)

Complex patient health needs and care delivery models such as patient participatory medicine require the ability to share data across multiple touch points. Achieving systematic performance management of care processes require an infrastructure that addresses interoperability and data standardization while supporting data governance and privacy compliance. In this paper, we present a framework for operationalizing privacy compliance for correlated cloud-hosted data using Data Sharing Agreements (DSAs) in support of performance management of community healthcare. Our focus is to show how DSAs can be used to operationalize privacy compliance for a cloud-hosted surveillance and performance management infrastructure by leveraging selective anonymization based on both organizational and patient consents. This allows a cloud-computing infrastructure to configure processes and services, including anonymization to ensure privacy compliance and a systematic approach to data governance.
Common sequence variants in chemokine-related genes and risk of breast cancer in post-menopausal women. (2013)

Our findings suggest that genetic variants in the 8 candidate genes coding for chemotactic cytokines have little influence in the risk of breast cancer in postmenopausal women. Additional examination of the relationship between CXCL12 rs1801157 and breast cancer risk is warranted.
Ferroelectric Liquid Crystal Display Using Tristable Switching (1990)

Smectic layer structure and switching behavior in antiferroelectric liquid crystals TFMHPOBC, TFMHPDBC and MHPOBC were studied. At the phase transition point between SmC * and SmC A * , discontinuity in the leaning angle and the layer spacing was observed. In the SmA phase, diffraction peaks attributable to the focal conic texture and the planar layer structure were observed, implying that the bookshelf structure and the focal conic texture coexist. Using the tristable switching, we designed the fundamental waveforms for multiplex driving and constructed a prototype antiferroelectric liquid crystal display which works at room temperature.
A comparison of the energy efficiency of selective laser sintering and injection molding of nylon parts (2012)

Purpose The purpose of this paper is to evaluate the energy consumed to fabricate nylon parts using selective laser sintering (SLS) and to compare it with the energy consumed for injection molding (IM) the same parts. Design/methodology/approach Estimates of energy consumption include the energy consumed for nylon material refinement, adjusted for SLS and IM process yields. Estimates also include the energy consumed by the SLS and IM equipment for part fabrication and the energy consumed to machine the injection mold and refine the metal feedstock required to fabricate it. A representative part is used to size the injection mold and to quantify throughput for the SLS machine per build. Findings Although SLS uses significantly more energy than IM during part fabrication, this energy consumption is partially offset by the energy consumption associated with production of the injection mold. As a result, the energy consumed per part for IM decreases with the number of parts fabricated while the energy consumed per part for SLS remains relatively constant as long as builds are packed efficiently. The crossover production volume, at which IM and SLS consume equivalent amounts of energy per part, ranges from 50 to 300 representative parts, depending on the choice of mold plate material. Research limitations/implications The research is limited to material refinement and part fabrication and does not consider other aspects of the life cycle, such as waste disposal, distributed 2 manufacturing, transportation, recycling or use. Also, the crossover volumes are specific to the representative part and are expected to vary with part geometry. Originality/value The results of this comparative study of SLS and IM energy consumption indicate that manufacturers can save energy using SLS for parts with small production volumes. The comparatively large amounts of nylon material waste and energy consumption during fabrication make it inefficient, from an energy perspective, to use SLS for higher production volumes. The crossover production volume depends on the geometry of the part and the choice of material for the mold.
Metabolite composition in breast tumors examined by proton nuclear magnetic resonance spectroscopy. (1999)

Large differences in the metabolite composition of breast tumors and surrounding breast tissues have been documented.
Kinematic optimization of a spherical mechanism for a minimally invasive surgical robot (2004)

Advances in surgical technology allow physicians to more effectively provide care to their patients. Minimally invasive surgery (MIS) has revolutionized the way a significant number of procedures are performed. Advances in technology have led to the fusion of MIS techniques and robotic devices; however, such systems are currently large and cumbersome. By optimizing a spherical mechanism based on in-vivo data collected during MIS procedures, this paper focuses on a bottom-up approach in developing a new class of surgical robot arms. The spherical mechanism is a rotational manipulator with all axes intersecting at the center of the sphere. Locating the rotational center of the mechanism at the MIS port makes this class of mechanism a suitable candidate for the first two links of a surgical robot for both minimally invasive and open surgery. For optimizing the mechanism structure, the forward and inverse kinematics, as well as the Jacobian matrix, were derived. Using the Jacobian, mechanism isotropy was considered as the performance metric. The dexterous workspace (DWS) is defined as a high dexterity region defined by a right circular cone with a vertex angel of 60/spl deg/ in which 95% of the tool motions are contained based on in-vivo measurements. The extended dexterous workspace (EDWS) is defined as the workspace required to reach the entire abdominal cavity with MIS instruments and defined by a cone with an elliptical cross section created by two orthogonal vertex angels of 60/spl deg/ and 90/spl deg/. Optimization across both the DWS and a superset of the EDWS led to a mechanism configuration with link length angles of 74/spl deg/ and 60/spl deg/ that maximizes kinematic performance and compactness. The workspace of this design covers the entire EDWS and is the optimal design for the next generation of surgical manipulator. By directly applying in-vivo experimental data from MIS in order to optimize the spherical manipulator a design that maximizes performance and minimizes size has been developed. A pair of prototype manipulators is developed based on these results.
Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain. (1994)

We have cloned a novel receptor tyrosine kinase that has an unusual ectodomain. The extracellular sequence consists of 416 amino acids and has none of the structural motifs that have been found in other receptor tyrosine kinases. The 150 amino acids in the amino terminus of the receptor is homologous to a putative phospholipid-binding sequence that is found also in other cell adhesion molecules such as the neuronal A5 antigen and coagulation factors V and VIII. The kinase domain has a short cytoplasmic tail and contains a short insert between subdomains I and II. The structure of this receptor kinase suggests that it belongs to a new family of receptors involved in cell-cell interactions. The cell adhesion kinase (Cak) is expressed at low levels in most adult tissues and expression is highest in the brain and lung. Using fluorescence in situ hybridization and interspecific backcross mapping, the Cak gene was localized to human chromosome 6 and mouse chromosome 17.
An ATP-dependent L-carnitine transporter in Listeria monocytogenes Scott A is involved in osmoprotection (1995)

Listeria monocytogenes is a gram-positive, psychotrophic, food-borne pathogen which is able to grow in osmotically stressful environments. Carnitine (beta-hydroxy-L-tau-N-trimethyl aminobutyrate) can contribute significantly to growth of L. monocytogenes at high osmolarity (R. R. Beumer, M. C. te Giffel, L. J. Cox, F. M. Rombouts, and T. Abee, Appl. Environ. Microbiol. 60:1359-1363, 1994). Transport of L-[N-methyl-14C]carnitine in L. monocytogenes was shown to be energy dependent. Analysis of cell extracts revealed that L-carnitine was not further metabolized, which supplies evidence for its role as an osmoprotectant in L. monocytogenes. Uptake of L-carnitine proceeds in the absence of a proton motive force and is strongly inhibited in the presence of the phosphate analogs vanadate and arsenate. The L-carnitine permease is therefore most likely driven by ATP. Kinetic analysis of L-carnitine transport in glucose-energized cells revealed the presence of a high-affinity uptake system with a Km of 10 microM and a maximum rate of transport (Vmax) of 48 nmol min-1 mg of protein-1. L-[14C]carnitine transport in L. monocytogenes is significantly inhibited by a 10-fold excess of unlabelled L-carnitine, acetylcarnitine, and tau-butyrobetaine, whereas L-proline and betaine display, even at a 100-fold excess, only a weak inhibitory effect. In conclusion, an ATP-dependent L-carnitine transport system in L. monocytogenes is described, and its possible roles in cold adaptation and intracellular growth in mammalian cells are discussed.
Chondroitin 6‐sulphate synthesis is up‐regulated in injured CNS, induced by injury‐related cytokines and enhanced in axon‐growth inhibitory glia (2005)

Chondroitin sulphate proteoglycans (CSPGs) are up-regulated in the CNS after injury and inhibit axon regeneration mainly through their glycosaminoglycan (CS-GAG) chains. We have analysed the mRNA levels of the CS-GAG synthesizing enzymes and measured the CS-GAG disaccharide composition by chromatography and immunocytochemistry. Chondroitin 6-sulfotransferase 1 (C6ST1) is up-regulated in most glial types around cortical injuries, and its sulphated product CS-C is also selectively up-regulated. Treatment with TGFalpha and TGFbeta, which are released after brain injury, promotes the expression of C6ST1 and the synthesis of 6-sulphated CS-GAGs in primary astrocytes. Oligodendrocytes, oligodendrocyte precursors and meningeal cells are all inhibitory to axon regeneration, and all express high levels of CS-GAG, including high levels of 6-sulphated GAG. In axon growth-inhibitory Neu7 astrocytes C6ST1 and 6-sulphated GAGs are expressed at high levels, whereas in permissive A7 astrocytes they are not detectable. These results suggest that the up-regulation of CSPG after CNS injury is associated with a specific sulphation pattern on CS-GAGs, mediating the inhibitory properties of proteoglycans on axonal regeneration.
Operating temperature effect in WO<inf>3</inf> films for gas sensing (2013)

WO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> film sputtered on Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> was used to sense ppm concentrations of NO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and NH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> gas. The optimum working temperature of the amorphous film was found to be 200°C for both the gases, in accordance with literature. However, thermo-gravimetric analysis of the films predicts a different mechanism from that in literature which speculates that there is loss of water molecules from WO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> at 200°C and therefore better sensing response. Thermo-gravimetric analysis shows that there is an increase in weight percentage in air at 200°C, which we speculate to be due to optimum surface oxygen content which leads to better sensing response. Raman spectroscopy at 200°C supports our speculation by showing no structural change in the WO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> compound and no shifting of the ~700 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> peak which is indicative of water loss. Furthermore, there was a marked change in the heating-cooling hysteresis at 200°C, which could result from the optimum surface oxygen content changing the electron transport properties The 200°C may also be regarded as a new transition temperature in WO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> although the transition is not structural (electron-phonon coupling) but is electronic in nature (electron-electron correlation) and this transition temperature could be linked to the optimum sensing temperature of WO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> .
FRAGMENTATION INDEX OF RAW MUSCLE AS A TENDERNESS PREDICTOR OF STEAKS FROM USDA COMMERCIAL AND UTILITY CARCASSES (1980)

ABSTRACT Loin steaks were removed from USDA Commercial (n=38) and Utility (n=42) beef carcasses to facilitate study of Fragmentation Index (PI). Tenderness was assessed by the Warner‐Bratzler shear (WBS) and a trained, 8‐member sensory panel. To determine the minimum time required to obtain the FI for fresh and frozen raw longissimus muscle, three drying times were studied (10 min, 40 min, and 22 hr). Simple correlation coefficients relating FI to WBS force value and sensory tenderness rating were: fresh muscle FI (10 min), 0.60 and ‐0.60; frozen muscle FI (40 min), 0.73 and ‐0.69, respectively. USDA grade factors and simultaneous consideration of all all measures of fragmentation accounted for 14.1 and 61.1%, respectively, of the observed variation in WBS force values. PI determined from frozen longissimus muscle accounted for 18.6‐23.8s more of the observed variation in cooked meat tenderness than FT of fresh muscle. The best two‐variable regression model accounted for 56.6% of the observed variation in WBS force value.
The Child Behavior Checklist Together with the ADHD Rating Scale Can Diagnose ADHD in Korean Community-Based Samples (2005)

These findings suggest that the combined use of the CBCL and the ARS could serve as a rapid and useful clinical method of predicting or even diagnosing children with ADHD in epidemiologic case definitions.
Autopsy Findings After Intracranial Thrombectomy for Acute Ischemic Stroke (2010)

In this highly selected group of patients, the vascular pathological abnormalities affecting basal arteries were variable, but complicated atherosclerosis was a common finding. Extensive irreversible brain necrosis before therapeutic procedures may have contributed to deaths.
Pulsed Flow Turbine Design Recommendations (2021)

A preliminary analysis of turbine design, fit for pulsed flow is proposed in this paper. It focuses on an academic 2D configuration using inviscid flows, since pressure loads due to wave propagation are several order of magnitude higher than friction and viscous effects do not significantly impinge on the inviscid part. As such, a large parametric study is carried out using the design of experiments methodology. A performance indicator adapted to unsteady environment is carefully defined before detailing the factors chosen for the design of experiments. Since the number of factors is substantial, a screening design to identify the factors influence on the output is first established. The non-influential factors were then omitted in a more quantitative study of the output law. The surface response calculation allows to determine the factors level favouring the best output. Consequently, the main trends in the turbine design driven by a pulsed flow can be stated.