gebhart/patrepeval huggingface dataset:
RECORRIDOS. ALUMNOS DE NUEVO INGRESO REALIZARON PASEOS DE RECONOCIMIENTO POR LOS CAMPOS DE LA UNAM (2011)

ANTES DEL PRIMER DIA DE CLASES YA ESTABAN EN LAS AULAS. MILES DE JOVENES DE PRIMER INGRESO SE DIERON CITA EN LOS PLANTELES DE LA ESCUELA NACIONAL PREPARATORIA, EL COLEGIO DE CIENCIAS Y HUMANIDADES Y FACULTADES PARA, DIJERON, RECIBIR LA BIENVENIDA POR PARTE DE LAS AUTORIDADES, AUNQUE EN REALIDAD LA MAYORIA ESTABA AHI PORQUE TENIA CURIOSIDAD DE SABER COMO SER  EL LUGAR DONDE ESTUDIAR N LOS SIGUIENTES TRES O CUATRO ANOS. PARA GUIAR A LOS NUEVOS UNIVERSITARIOS, DECENAS DE ALUMNOS Y EXALUMNOS COLABORARON CON PROFESORES EN LOS RECORRIDOS POR LAS DIVERSAS INSTALACIONES UNIVERSITARIAS. SE PRESENTAN TESTIMONIOS DE ALUMNOS DE PRIMER INGRESO DE BACHILLERATO Y LICENCIATURA, Y DE LOS GUIAS. ASIMISMO, EN LAS P GINAS CENTRALES, SE INCLUYEN IM GENES DE ALGUNOS DE LOS RECORRIDOS POR LAS INSTALACIONES DE LA UNAM.
Next Generation In-game Message Interfaces (2007)

Instant messenger tools, such as AIM, MSN or ICQ have become fairly popular within the gaming community in the last years. On pair with the intensive use of game specific forums, these tools offer the player the keen advantage of having an individual buddy list with communication options outside the game. However especially next generation MMORPGs with full-screen playing option force the player to completely focus on the in-game chat mechanism. In order to create a satisfying solution for the current situation the parallel use of both applications at the same time is ineffective. This paper presents an integration of the AIM (AOL Instant Messenger) into the Eve-Online client. The integration includes an overview about the underlying network protocol OSCAR as well as a framework with interfaces towards game-engine and chat-protocol. With the very flexible and generic implementation the interfaces can basically be customized for any other games/ chat-client. Furthermore an online-survey concludes the most important information about player in-game chatting behavior.
L-band output network (1991)

In the INMARSAT-3 system, the L-band output network (ONET) interfaces between the SSPAs and the antenna feeds. It provides filtering of the output signal and uses Butler matrix hybrid networks for routing power to one, or all, of the 22 antenna feeds, depending on the relative phasing of the input signals, as set by the preceding beam former. The authors describe the design and performance of the re-entrant cavity bandpass filter, its associated coaxial low pass filter, and the stripline 4*4 matrices. Performance figures are presented for transmission characteristics and phase tracking. Additional to the twenty two identical ONET filters, there is a requirement for a single output filter in the navigation channel. Having higher frequency, lower bandwidth and sharper cut-off than the ONET filter, this was realised in evanescent mode construction. Design and performance details are given.
Bone marrow MSCs in MDS: contribution towards dysfunctional hematopoiesis and potential targets for disease response to hypomethylating therapy (2018)

In the original version of this article there was a mistake in the spelling of the author Sujoy Ghosh, originally spelt Sujoy Gosh. This has now been corrected in both the PDF and HTML versions of the article.
Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex. (1989)

Several genes were found closely associated with major histocompatibility class I and class II beta-chain genes in chicken genomic DNA clusters by hybridizing tissue-specific cDNA probes to cosmid clones. A cDNA probe for one of these genes, probe C12.3 isolated from a chicken liver cDNA library, was used to clone the homologous sequence H12.3 from a human B-lymphoblastoid cell line cDNA library. C12.3 and H12.3 encode exactly the same 317-residue-long protein. The sequence of 12.3 shows significant homology with the two known guanine nucleotide-binding protein beta subunits (GP beta 1 and GP beta 2) and other proteins that all share the same segmented structure with seven internal homologous repeats about 45 residues in length. Unlike the chicken gene, the human H12.3 gene and its mouse counterpart are not located on the same chromosome as the major histocompatibility complex. A possible involvement of the C12.3 gene product in major histocompatibility complex-linked control of lymphocyte proliferation in chickens is discussed.
Synthesis and Explosive Properties of Dinitropicrylbenzimidazoles, and the 'Trigger Linkage' in Dinitropicrylbenzotriazoles (1992)

The synthesis of certain dinitropicrylbenzimidazoles and their structural elucidation are described. The explosive properties are discussed, and compared with those of the corresponding benzotriazoles. These comparisons allow the identification of the Pic-N-N=N moiety as containing the 'trigger linkage' for impact initiation of picrylbenzotriazoles.
In vivo efficacy of melanoma internal radionuclide therapy with a 131I‐labelled melanin‐targeting heteroarylcarboxamide molecule (2013)

The development of alternative therapies for melanoma treatment is of great interest as long-term tumour regression is not achieved with new targeted chemotherapies on selected patients. We previously demonstrated that radioiodinated heteroarylcarboxamide ([131I]ICF01012) induced a strong anti-tumoural effect by inhibiting both primary tumour growth and dissemination process in a B16BL6 melanoma model. In our study, we show that a single injection of [131I]ICF01012 (ranging from 14.8 to 22.2 MBq) was effective and associated with low and transient haematological toxicity. Concerning pigmented organs, cutaneous melanocytes and skin were undamaged. In 30% of treated animals, no histological alteration of retina was observed, and in the remaining 70%, damages were restricted to the optic nerve area. Using the Medical Internal Radiation Dose methodology, we determined that the absorbed dose in major organs is very low (<4 Gy) and that a delivery of 30 Gy to the tumour is sufficient for an effective anti-tumoural response. Molecular analyses of treated tumours showed a strong radiobiological effect with a decrease in proliferation, survival and pro-angiogenic-related markers and an increase in tumour suppressor gene expression, melanogenesis and anti-angiogenic markers. All these features are in accordance with a tumour cell death mechanism that mainly occurs by mitotic catastrophe and provide a better understanding of in vivo anti-tumoural effects of [131I] radionuclide. Our findings raise [131I]ICF01012 a good candidate for disseminated melanoma treatment and strongly support transfer of [131I]ICF01012 to clinical trial.
Antibodies to β2‐glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus (1996)

The results suggest that pathogenic aCL is directed against structurally altered beta 2GPI and that enzyme immunoassay for anti-beta 2GPI may prove useful in evaluating the risk of thrombosis and monitoring the clinical course in patients with SLE.
Experiences, attitudes, and perceptions of caregivers of individuals with treatment-resistant schizophrenia: a qualitative study (2018)

Persistent positive symptoms caused significant perceived burden, feelings of being overwhelmed and having no relief, and substantial negative impacts on caregivers' emotional and physical health. To address these substantial unmet needs, policy makers should be aware of the need for practical, social, and emotional support for these caregivers and their families. Additionally, new treatment options for TRS should be developed.
Rolling of Ferromagnetic Ferrite Powder by Use of Synthetic Rubber. (1992)

A magnetic composite material is fabricated by rolling. Anisotropic strontium ferrite powder, Zn-22Al superplastic powder and synthetic rubber are mixed with various mixing ratio and then kneaded. The kneaded compact is rolled at temparature ranging from 50°C to 120°C. It is investigated with regard to fabrication factors such as rolling reduction, rolling temperature, mixing ratio of ferromagnetic powder and Zn-22Al superplastic one, and addition of calcium stearate on characteristics of the magnetic composite material.The magnetic comosite material imparts flexibility under load. It is found that the optimum forming conditions are a reduction of approximately 90% and a rolling temperature of 80°C Residual flux density of the magnetic composite material almost reaches the theoretical value for a given ferrite content per unit volume. This means that orientation of the ferromagnetic powder is accomplished almost completely.
Facial attractiveness prediction using psychologically inspired convolutional neural network (PI-CNN) (2017)

This paper proposes a psychologically inspired convolutional neural network (PI-CNN) to achieve automatic facial beauty prediction. Different from the previous methods, the PI-CNN is a hierarchical model that facilitates both the facial beauty representation learning and predictor training. Inspired by the recent psychological studies, significant appearance features of facial detail, lighting and color were used to optimize the PI-CNN facial beauty predictor using a new cascaded fine-tuning method. Experiments indicate that the cascaded fine-tuned PI-CNN predictor is robust to facial appearance variances, and obtains the highest correlation of 0.87 in the SCUT-FBP benchmark database, which is superior to the related hand-designed feature and related deep learning methods.
Close Approximations of Sigmoid Functions by Sum of Steps for VLSI Implementation of Neural Networks (1994)

This paper is devoted to show that there are simple and accurate ways to compute a sigmoid nonlinearity and its derivative in digital hardware by sum of steps, and that threshold gate implementation of such algorithms are area-efficient when compared to other known methods.&amp;lt;E-26&amp;gt; 1. OVERVIEW&amp;lt;E-111&amp;gt; The paper starts by describing classical solutions for digital hardware implementation of the nonlinear activation functions used by artificial neurons, the accent falling on sigmoid nonlinearities. Fresh results from the known literature are mentioned and shortly compared (2. Classical Solutions). But even if approximation techniques are used, the computations involved are quite complex. That is why we introduce a particular sigmoid function (3. A Particular Sigmoid Function). It is not very difficult to show that this particular sigmoid function is equivalent with the classical sigmoid function if the amplification factor (gain) is changed by a constant. As this constant can be used to m...
Supplementary Figure 1 from Methylation of the Polycomb Group Target Genes Is a Possible Biomarker for Favorable Prognosis in Colorectal Cancer (2023)

&lt;p&gt;PDF file - 1106K, Methylation of the PCGT genes is enriched in the tumors. Percentage Methylated Ratio (PMR) in pairs of colon tumors (Tumor) and their matching non-malignant tissues (Normal)&lt;/p&gt;
Competition between protein folding and aggregation: A three-dimensional lattice-model simulation (2001)

Aggregation of protein molecules resulting in the loss of biological activity and the formation of insoluble deposits represents a serious problem for the biotechnology and pharmaceutical industries and in medicine. Considerable experimental and theoretical efforts are being made in order to improve our understanding of, and ability to control, the process. In the present work, we describe a Monte Carlo study of a multichain system of coarse-grained model proteins akin to lattice models developed for simulations of protein folding. The model is designed to examine the competition between intramolecular interactions leading to the native protein structure, and intermolecular association, resulting in the formation of aggregates of misfolded chains. Interactions between the segments are described by a variation of the Go potential [N. Go and H. Abe, Biopolymers 20, 1013 (1981)] that extends the recognition between attracting types of segments to pairs on distinct chains. For the particular model we adopt, the global free energy minimum of a pair of protein molecules corresponds to a dimer of native proteins. When three or more molecules interact, clusters of misfolded chains can be more stable than aggregates of native folds. A considerable fraction of native structure, however, is preserved in these cases. Rates of conformational changes rapidly decrease with the size of the protein cluster. Within the timescale accessible to computer simulations, the folding-aggregation balance is strongly affected by kinetic considerations. Both the native form and aggregates can persist in metastable states, even if conditions such as temperature or concentration favor a transition to an alternative form. Refolding yield can be affected by the presence of an additional polymer species mimicking the function of a molecular chaperone.
Respiratory mechanics in the normal dog determined by expiratory flow interruption (1989)

We recently proposed an eight-parameter model of the respiratory system to account for its mechanical behavior when flow is interrupted during passive expiration. The model consists of two four-parameter submodels representing the lungs and the chest wall, respectively. The lung submodel consists of an airways resistance together with elements embodying the viscoelastic properties of the lung tissues. The chest wall submodel has similar structure. We estimated the parameters of the model from data obtained in four normal, anesthetized, paralyzed, tracheostomized mongrel dogs. This model explains why lung tissue and chest wall resistances should be markedly frequency dependent at low frequencies and also permits a physiological interpretation of resistance measurements provided by the flow interruption method.
Neuroimaging Assessment of Cerebrovascular Reactivity in Concussion: Current Concepts, Methodological Considerations, and Review of the Literature (2016)

Concussion is a form of traumatic brain injury (TBI) that presents with a wide spectrum of subjective symptoms and few objective clinical findings. Emerging research suggests that one of the processes that may contribute to concussion pathophysiology is dysregulation of cerebral blood flow (CBF) leading to a mismatch between CBF delivery and the metabolic needs of the injured brain. Cerebrovascular reactivity (CVR) is defined as the change in CBF in response to a measured vasoactive stimulus. Several magnetic resonance imaging (MRI) techniques can be used as a surrogate measure of CBF in clinical and laboratory studies. In order to provide an accurate assessment of CVR, these sequences must be combined with a reliable, reproducible vasoactive stimulus that can manipulate CBF. Although CVR imaging currently plays a crucial role in the diagnosis and management of many cerebrovascular diseases, only recently have studies begun to apply this assessment tool in patients with concussion. In order to evaluate the quality, reliability, and relevance of CVR studies in concussion, it is important that clinicians and researchers have a strong foundational understanding of the role of CBF regulation in health, concussion, and more severe forms of TBI, and an awareness of the advantages and limitations of currently available CVR measurement techniques. Accordingly, in this review, we (1) discuss the role of CVR in TBI and concussion, (2) examine methodological considerations for MRI-based measurement of CVR, and (3) provide an overview of published CVR studies in concussion patients.
Promiscuous Coupling of Receptors to Gq Class α Subunits and Effector Proteins in Pancreatic and Submandibular Gland Cells (1998)

Mice with deficiencies in one or more Gq class alpha subunit genes were used to examine the role of the alpha subunit in regulating Ca2+ signaling in pancreatic and submandibular gland cells. Western blot analysis showed that these cells express three of the four Gq class subunits, Galphaq, Galpha11, and Galpha14 but not Galpha15. Surprisingly, all parameters of Ca2+ signaling were identical in cells from wild type and four lines of mutant mice: 1) Galpha11-/-, 2) Galpha11-/-/Galpha14-/-, 3) Galpha14-/-/Galpha15-/-, and 4) Galphaq-/-/Galpha15-/-. These parameters included the Kapp for several Gq class coupled receptors, induction of [Ca2+]i oscillations by weak stimulation, and a biphasic [Ca2+]i response by strong stimulation. Furthermore, Ca2+ release from internal stores and Ca2+ entry were not affected in cells from any of the mutant mice. We conclude that Galphaq, Galpha11, and Galpha14 promiscuously couple several receptors (m3 muscarinic, bombesin, cholecystokinin, and alpha1 adrenergic) to effector proteins that activate both Ca2+ release from internal stores and Ca2+ entry.
Precision Geodesy Using the Mark-III Very-Long-Baseline Interferometer System (1985)

Very-long-baseline interferometry (VLBI) has been used to make precise measurements of the vector separation between widely separated antennas. The system for acquiring and processing VLBI data known as Mark-III is described. Tests of the system show it to have millimeter-level accuracy on short baselines; measurements of baselines longer than a few hundred kilometers suggest that accuracy is limited by the uncertainty in the calibration of tropospheric path delay to the level of a few centimeters. VLBI experiments conducted between 1976 and 1983 have demonstrated the stability of the North American plate by showing that there is no change in the distance between easternl-California and Massachusetts at the level of a few millimeters per year or greater. Experiments made from 1980 to 1984 indicate that the distance from Massachusetts to Sweden is increasing by 1.7 ± 1 cm/year where the quoted standard deviation includes the estimated effects of systematic atic errors
Inhibitory effect of endostatin expressed by human liver carcinoma SMMC7721 on endothelial cell proliferationin vitro (2002)

Human endostatin can be stably expressed by SMMC7721 cell transferred with human endostatin gene and its product can significantly inhibit the proliferation of human umbilical vein endothelial cell in vitro.
Corrigendum: Pyrrolopyrrole Cyanine Dyes: A New Class of Near‐Infrared Dyes and Fluorophores (2012)

The Supporting Information file has been replaced to indicate that the synthesis was performed by using tert-amylalcohol.
Vascularized Bone Grafting for Reconstruction of Oncologic Defects in the Spine: A Systematic Review and Pooled Analysis of the Literature (2018)

Our results demonstrate that complication rates using VBG are similar to those reported in studies using non-VBG for similar spinal reconstructions; however, fusion rates are better. Given rapid fusion and possible hardware independence, VBG may be useful in reconstructing defects in patients with longer life expectancies and/or with a history of chemoradiation and/or infection at the site of tumor resection.
Automatic boundary detection on cardiac magnetic resonance image sequences for four dimensional visualization of the left ventricle (2002)

The authors describe a knowledge-based system for detecting the interior and exterior boundaries of the left ventricle (LV) from time-varying cross-sectional images of the beating heart obtained noninvasively by magnetic resonance imaging (MRI). The system automatically classifies and measures cardiac function through estimates of LV wall thickness, wall motion, etc. The system is knowledge based and it makes use of Dempster-Shafer theory to manage the knowledge. This theory is also used to control the flow of system information for more efficient use of limited computational resources and memory space.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The new XCAT series of digital phantoms for multi-modality imaging (2010)

We developed a series of 4D Extended Cardiac-Torso (XCAT) phantoms for multimodality imaging research. Highly detailed whole-body anatomies for the initial adult male and female were previously defined for the XCAT using nonuniform rational b-spline (NURBS) surfaces based on the Visible Male and Female anatomical datasets from the National Library of Medicine. To extend the XCAT beyond these adult models, we utilized innovative methods in computational anatomy to efficiently create new phantoms by mapping the template XCAT anatomy (male or female) to match the anatomical framework provided by patient CT data. We applied these methods to create a series of 4D XCAT phantoms representing both genders with varying ages, heights, and weights from pediatric to adult patients. Forty-seven phantoms were created in total, 25 male and 22 female, each containing thousands of anatomical objects. To demonstrate the usefulness of the phantoms, we show example simulation studies in PET, SPECT, and CT using publicly available simulation packages. As demonstrated in the pilot studies, the 4D XCAT series can produce realistic imaging data when combined with accurate models of the imaging process. Distributed to the research community, such a unique library of computational models will have a widespread use in imaging research to quantitatively evaluate and improve imaging devices and techniques and to investigate the effects of anatomy and motion.
Tri(tert-butyl)phosphinoxid, -imin, -methylen und -boran / Tri(tert-butyl)phosphine Oxide, Imine, Methylene and Borane (1978)

Abstract Tri(tert-butyl)phosphine Oxide, Imine, Methylene, Borane Tri(tert-butyl)phosphine oxide, imine, methylene and borane have been prepared and their properties investigated. The imine is chemically inert due to strong steric hindrance. Its thermal decomposition at 200 °C leads to tri(tert-butyl)-pliosphine, in contrast to the methylene analogue which undergoes reductive elimination of isobutene. Both the oxide and borane are thermally very stable (&gt; 250 °C).
Rapid target allopurinol concentrations in the hypoxic fetus after maternal administration during labour (2013)

The study is registered in the Dutch Trial Register (NTR1383) and the Clinical Trials protocol registration system (NCT00189007).
Self‐Assembled Peptide Amphiphile Nanofibers for Controlled Therapeutic Delivery to the Atherosclerotic Niche (2021)

Atherosclerotic plaque remains the leading contributor to cardiovascular disease and requires invasive surgical procedures for its removal. Nanomedicine offers a minimally invasive approach to alleviate plaque burden by targeted therapeutic delivery. However, nanocarriers are limited without the ability to sense and respond to the diseased microenvironment. In this study, targeted self-assembled peptide amphiphile (PA) nanofibers were developed that cleave in response to biochemical cues expressed in atherosclerotic lesions-reactive oxygen species (ROS) and intracellular glutathione-to deliver a liver X receptor agonist (LXR) to enhance macrophage cholesterol efflux. The PAs released LXR in response to physiological levels of ROS and reducing agents and could be co-assembled with plaque-targeting PAs to form nanofibers. The resulting LXR PA nanofibers promoted cholesterol efflux from macrophages <i>in vitro</i> as well as LXR alone and with lower cytotoxicity. Further, the ApoA1-LXR PA nanofibers targeted plaque within an atherosclerotic mouse model <i>in vivo</i> and activated ATP-binding cassette A1 (ABCA1) expression as well as LXR alone with reduced liver toxicity. Taken together, these results demonstrate the potential of self-assembled PA nanofibers for controlled therapeutic delivery to the atherosclerotic niche.