gebhart/patrepeval huggingface dataset:
P11.08: Ultrasound detection of nuchal cord before labor in pregnant women at ≥ 41.0 weeks' gestation (2006)

To investigate the ability of an ultrasound performed before labor to detect the presence of a nuchal cord at delivery in pregnant women at ≥ 41.0 weeks' gestation. We scanned 98 pregnant women at ≥ 41.0 weeks' gestation with color Doppler before labor. The presence of a nuchal cord was recorded and classified as present or absent. The labor was leave to evolve or was induced in case of pathology or when pregnancy reached 42.0 weeks. The presence of nuchal cord at delivery was specifically sought and accordingly recorded in the files. The outcomes of labor, delivery and perinatals results were also obtained from the clinical records. A nuchal cord was present at 27.6% of the scans and 29.6% of deliveries. The mean and SD of gestational age and amniotic fluid volume at ultrasound were 41.4 ± 0.3 weeks and 8.3 ± 4.2 cm, respectively. Range of the interval between scan and delivery was 0–5 days (mean 1.9 ± 1.3 days). Spontaneous labor evolved in 40% of women. The mean gestational age and birthweight at delivery were 41.7 ± 0.3 weeks and 3492 g ± 400 g. Overall Cesarean rate was 31.6%. Cesarean was indicated for fetal distress in 11.2% women. The sensitivity of ultrasound in diagnosing a nuchal cord was 58.6% with specificity, positive and negative predictive values of 85.5%, 63% and 83% respectively. The value of the ultrasound before labor to predict the presence of nuchal cord at delivery in women of ≥ 41 weeks' gestation is limited.
Androstenetriol and Androstenediol: Protection Against Lethal Radiation and Restoration of Immunity After Radiation Injury (2000)

Androstenetriol (AET) and Androstenediol (AED) upregulate host immunity, leading to increased resistance against infections. AET augments IL-2, IL-3, IFN gamma levels, and counteracts hydrocortisone immune suppression. AET and AED at a dose of 0.75 mg/- and 8.0 mg/25-g mouse, protected 60 and 70%, respectively, of C57/BL/6J mice irradiated with a lethal dose. These hormones also protected mice irradiated with 6 Gy and infected with a coxsackievirus B4 LD50. AET significantly increased spleen lymphocyte numbers at 7, 14, and 21 days after a 6-Gy exposure. Fluorescent activated cell-sorter analysis of irradiated mice, spleen, and bone marrow showed that AET significantly augmented the myeloid precursor markers, CD11b/Mac-1, and B220 (pan B), as well as the absolute numbers of CD4+/CD8+ cells over the 21 days of testing. Overall, the data are consistent with AET/AED inducing a more rapid recovery of all hematopoietic precursors from the small number of surviving stem cells.
Model Predictive Control and Disturbance Compensation for Engine Test Beds (2020)

Engine test beds play a big role in developing and validating all sorts of drive systems. Utilizing them for Hardware-in-the-Loop (HIL) tests enables parallel development of components and therefore decreases the overall design process time. The controllers for such tests need to be highly accurate in order to justify emulation of real-world operations. When combustion engines are considered, a common problem with engine test beds are the periodic oscillations that are induced by the combustion strokes. Ordinary controllers try to compensate these oscillations and thereby, introduce additional, undesired loads to the device under test (DUT). In this paper, a way to overcome this problem is presented. A model predictive control scheme uses information about future disturbances to regulate the engine speed. The unknown combustion torque is estimated by a parametric Kalman filter. Experimental results on a laboratory setup prove the practicability of the proposed methods.
Joint modeling of longitudinal data with informative cluster size adjusted for zero‐inflation and a dependent terminal event (2021)

Repeated measures are often collected in longitudinal follow-up from clinical trials and observational studies. In many situations, these measures are adherent to some specific event and are only available when it occurs; an example is serum creatinine from laboratory tests for hospitalized acute kidney injuries. The frequency of event recurrences is potentially correlated with overall health condition and hence may influence the distribution of the outcome measure of interest, leading to informative cluster size. In particular, there may be a large portion of subjects without any events, thus no longitudinal measures are available, which may be due to insusceptibility to such events or censoring before any events, and this zero-inflation nature of the data needs to be taken into account. On the other hand, there often exists a terminal event that may be correlated with the recurrent events. Previous work in this area suffered from the limitation that not all these issues were handled simultaneously. To address this deficiency, we propose a novel joint modeling approach for longitudinal data adjusting for zero-inflated and informative cluster size as well as a terminal event. A three-stage semiparametric likelihood-based approach is applied for parameter estimation and inference. Extensive simulations are conducted to evaluate the performance of our proposal. Finally, we utilize the Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) study for illustration.
Simultaneous Determination of Organic and Cationic Species in Explosives Residues with Column-Switching Liquid Chromatography-Ion Chromatography System (2011)

A new column-switching method has been proposed for the determination of 14 organic explosives (1,3,5,7-tetranitro-N-methylaniline, 1,3,5-trinitro-1,3,5-triazacyclohexane, 1,3,5-trinitrobenzene, 1,3-dinitrobenzene, nitrobenzene, 2,4,6-N-tetranitro-N-methylaniline, Trinitrotoluene, 4-amino-2,6-dinitrotoluene, 2-amino-4,6-dinitrotoluene, 2,6-dinitrotoluene, 2,4-dinitrotoluene, 2-nitrotoluene, 4-nitrotoluene, and 3-nitrotoluene) and/or five inorganic cations (Na(+), NH(4)(+), K(+), Mg(2+), and Ca(2+)) using liquid chromatography linked to ion chromatography by a switching valve. The mobile phase was methanol-water (40/60, v/v) for a C18 reversed-phase column and 3 mM of methanesulfonic acid (pH 2.5) for a cation-exchange column, respectively. Under the optimal conditions, the 14 organic explosives and the five inorganic cations were separated and detected simultaneously within 45 min. The limits of detection (S/N = 3) of the 14 organic explosives and the five inorganic cations were in the range of 0.0048-0.0333 mg/L and 0.0116-0.1851 mg/L, respectively. The linear correlation coefficients were 0.9971-0.9999, and the relative standard deviation of the retention time and the peak area were 0.02-0.31% and 0.51-3.64%, respectively. The method was successfully applied to the determination of organic explosives and inorganic cations in dust samples.
Blocking Adult Images Based on Statistical Skin Detection (2004)

This work is aimed at the detection of adult images that appear in Internet. Skin detection is of the paramount importance in the detection of adult images. We build a maximum entropy model for this task. This model, called the First Order Model in this paper, is subject to constraints on the color gradients of neighboring pixels. Parameter estimation as well as optimization cannot be tackled without approximations. With Bethe tree approximation, parameter estimation is eradicated and the Belief Propagation algorithm permits to obtain exact and fast solution for skin probabilities at pixel locations. We show by the Receiver Operating Characteristics (ROC) curves that our skin detection improves the performance in the previous work in the context of skin pixel detecton rate and false positive rate. The output of skin detection is a grayscale skin map with the gray level indicating the belief of skin. We then calculate 9 simple features from this map which form a feature vector. We use the fit ellipses to catch the characteristics of skin distribution. Two fit ellipses are used for each skin map---the fit ellipse of all skin regions and the fit ellipse of the largest skin region. They are called respectively Global Fit Ellipse and Local Fit Ellipse in this paper. A multi-layer perceptron classifier is trained for these features. Plenty of experimental results are presented including photographs and a ROC curve calculated over a test set of 5,084 photographs, which show stimulating performance for such simple features.
A 1-Year-Old WithMycobacterium tuberculosisEndocarditis With Mass Spectrometry Analysis of Cardiac Vegetation Composition: Table 1. (2014)

In this study, we report the first case of Mycobacterium tuberculosis endocarditis in an immunocompetent child born in the United States. Mass spectrometry of the vegetation identified coagulation, humoral immune proteins, neutrophil granule proteins, and histones. Few neutrophils on histopathology suggest that neutrophil extracellular traps may contribute to tuberculous endocardiac mass formation.
Association of an APOBEC mutational signature, mutational load, and BRCAness with inflammation and PD-L1 expression in HNSCC. (2017)

e14613 Background: Immune checkpoints are an emerging treatment target in head and neck squamous cell carcinoma (HNSCC). Expression of PD-L1 and an IFNG immune signature have been shown as biomarkers of response. In this study we analyzed mutational signatures to identify recurrent mutational patterns associated with inflammation. Methods: HNSCC mutation and gene expression data were downloaded (n = 496, TCGA). Inflamed tumors were identified through upregulation of a predefined 6-gene IFNG immune signature. Mutational load, base exchange motifs and a BRCAness signature were analyzed in inflamed and non-inflamed tumors. Results were validated in independent datasets of cervical, urothelial and lung cancer (TCGA). Results: Total mutational load did not correlate with tumor inflammation (r = -0.03, p = 0.5). An APOBEC-associated tCw (thymine – cytosine – adenine/thymine) mutational signature was significantly associated with inflammation (r = 0.26, p = 2.923e-09). The tCw signature was furthermore correlated with the expression of PD-L1 and other immune checkpoints (r = 0.19, p = 1.723e-05). The TCW mutational signature correlated with the expression of APOBEC3 genes. Expression of APOBEC3 genes also correlated with tumor inflammation (r = 0.62, p &lt; 2.2e-16). As a second mutational signature, indels and an independent BRCAness signature were significantly enriched in non-inflamed tumors (p = 6.464e-14). Enrichment of an APOBEC mutational signature in inflamed tumors could be validated in cervical and urothelial carcinoma but not NSCLC. Conclusions: In HNSCC, overall mutational load is not associated with inflammation. BRCAness is significantly associated with immune-desertion whereas expression of APOBEC genes and an APOBEC mutational signature significantly correlates with the expression of PD-L1 and a T-cell inflamed signature. These findings suggest that a specific mutational pattern might serve as a biomarker for immune checkpoint inhibition in cancer.
Surveillance robotics: analyzing scenes by colors analysis and clustering (2004)

We describe a surveillance system which allows a mobile robot, operating within a familiar setting, to detect unexpected changes in the environment (i.e., presence or absence of objects or persons, unexpectedly opened/closed doors or windows, etc.). To achieve this, the robot "looks at" the environment through a TV camera; next, it compares what "it sees" in a specific moment with what "it should see" at that same location. In particular, an approach is proposed for images comparison which requires to find color clusters in the color histograms corresponding to the images to be compared: by analyzing the color clusters in the two images, the systems detects similarities or differences between them and consequently deduces if something has changed in the scene. Since the techniques proposed in literature usually rely on the geometrical characteristics of the objects to be detected (besides cromination), "ad hoc" algorithms have been implemented for color clusters comparison; the proposed techniques can be used alone or in cooperation with existing pattern recognition methods in order to increase the performance of the whole system.
The suitability of sapphire for laser windows (1999)

The present paper deals with the experimental measurement of absorption coefficients using (i) the differential dual-beam spectro-photometry method and (ii) an intra-cavity optical loss measurement technique. The absorption coefficient is measured experimentally in the region from the visible to the near IR. Criteria for choosing sapphire windows of optimum thickness, when they are subjected to a pressure difference of 1 atm, to avoid fracture or significant optical distortion of the laser beam are studied. Intra-cavity optical losses in such windows for Brewsterization and skew-angle inclusions are estimated. The study relates to various laser wavelengths, namely 337.1 nm, 448.0 nm, 632.8 nm, , , and .
Reduction in dental caries with four concentrations of sodium fluoride in a dentifrice: a meta-analysis evaluation. (2001)

Information on the effects of fluoride concentrations above 1,100 ppm in dentifrices is not extensive in the literature. The objective of this meta-analysis was to examine and compare the anticaries effectiveness (in terms of DMFS scores) of 1,700 ppm, 2,200 ppm and 2,800 ppm F- ion (as sodium fluoride) dentifrices vs. an 1,100 ppm F- ion (as sodium fluoride) control dentifrice based on results from six double-blind, randomized clinical studies, each conducted over a two- to three-year period. The studies each enrolled approximately 1,200-2,000 male and female school children per treatment group in grades I through 8, and were conducted in areas with low fluoride content water supplies in the states of Indiana, Pennsylvania, Ohio and Oregon. Separate meta-analyses were performed on the study results (DMFS increment scores determined by visual-tactile examinations supplemented with radiographs) for the one-year, two-year and three-year examinations. Comparisons of the 1,700 ppm F-, 2,200 ppm F-, and 2,800 ppm F- groups vs. the 1,100 ppm F- group were based on pooling the effect sizes for these comparisons from the individual studies. The effect sizes were calculated in two different ways, reflecting the analyses that were performed in the original studies: 1) effects based on the sample means and variances; and 2) effects based on the adjusted sample means and mean squared error from an analysis of covariance. The results obtained from this meta-analysis provide evidence that the use of a 2,800 ppm F- ion, as sodium fluoride, dentifrice results in statistically significantly lower caries increment than the use of an 1,100 ppm F- ion, as sodium fluoride, dentifrice. This result was noted after one, two, and three years of dentifrice use. The 1,700 ppm F- and 2,200 ppm F- dentifrice groups showed some directional advantages over the 1,100 ppm F- dentifrice group, however the analysis did not establish these groups as statistically significantly better than 1,100 ppm F-. The meta-analysis based on analysis of covariance results was somewhat more sensitive to treatment group differences than the analysis based on sample means and variances, as was expected.
From Target to Drug: Generative Modeling for the Multimodal Structure-Based Ligand Design (2019)

Chemical space is impractically large, and conventional structure-based virtual screening techniques cannot be used to simply search through the entire space to discover effective bioactive molecules. To address this shortcoming, we propose a generative adversarial network to generate, rather than search, diverse three-dimensional ligand shapes complementary to the pocket. Furthermore, we show that the generated molecule shapes can be decoded using a shape-captioning network into a sequence of SMILES enabling directly the structure-based de novo drug design. We evaluate the quality of the method by both structure- (docking) and ligand-based [quantitative structure-activity relationship (QSAR)] virtual screening methods. For both evaluation approaches, we observed enrichment compared to random sampling from initial chemical space of ZINC drug-like compounds.
Akt phosphorylation is required for heat acclimation‐induced neuroprotection (2007)

Long-term heat exposure, known as heat acclimation (HA; 30 days at 34 +/- 1 degrees C) is neuroprotective against traumatic brain injury. Acclimated mice were previously found to display improved functional recovery as well as an increase in the levels of the specific erythropoietin receptor. As the activation of this receptor is known to facilitate functional recovery on one hand and the phosphorylation and activation of Akt, an intracellular kinase which regulates anti-apoptotic pathways on the other, in this study we investigated whether HA affects Akt phosphorylation prior to and following injury and whether this step is required for development of HA-induced neuroprotection. Akt phosphorylation was blocked using Triciribine (TCN), a compound shown to block the phosphorylation process without affecting upstream effectors of this kinase, and several post-injury functional end-point measures were subsequently evaluated. Acclimation led to a post-injury increase in the levels of phosphorylated Akt, resulting in higher levels when compared with normothermic controls at 4 h post-injury (63.6 +/- 5.2% and 42.7 +/- 3.7%, respectively, p </= 0.05). This increase was diminished following TCN administration. Post-injury TCN treatment abolished the HA-induced functional benefits, including effects on motor and cognitive functions as well as the attenuation of edema formation. We therefore suggest that Akt phosphorylation is essential for HA-induced neuroprotection after traumatic brain injury.
Rapid diagnosis of enterovirus infection by magnetic bead extraction and polymerase chain reaction detection of enterovirus RNA in clinical specimens (1993)

We describe a rapid method for extraction and detection of enterovirus RNA in clinical samples. By using magnetic bead technology, enterovirus RNA was efficiently and rapidly extracted from cerebrospinal fluid, stool, saliva, blood, pericardial fluid, urine, and cryopreserved or formalin-fixed solid tissue. Enterovirus RNA was then detected by reverse transcription followed by polymerase chain reaction amplification with primers designed to allow detection of most enterovirus serotypes. For detection of enteroviruses in specimens from patients with acute enteroviral disease, the overall sensitivity of enzymatic RNA amplification was greater than that of cell culture isolation, especially in blood specimens and in stool specimens from patients with acute cardiac disease. Enterovirus RNA was also detected in cryopreserved and archival formalin-fixed myocardial tissue from patients with acute myocarditis and chronic dilated cardiomyopathy. The ability to study archival specimens is of particular value in conducting retrospective investigation. The RNA extraction procedure used was considerably faster than extraction methods using organic reagents, used less hazardous reagents, and was of similar sensitivity. This detection protocol may therefore be useful both for the diagnosis of enterovirus infection and in studying the pathogenesis of acute and chronic enterovirus-induced disease.
A High Speed All-Optical NAND Logic Gate Using Four-Wave Mixing (2015)

We demonstrate a high speed all-optical NAND gate based on four-wave mixing Bragg scattering in highly nonlinear fiber. A 15.2-dB depletion of the signal is obtained and time domain measurements show 10-Gb/s NAND operation.
Word length, sentence length and frequency – Zipf revisited (2004)

Abstract. This paper examines data from English, Swedish and German in order to find a theoretical distribution that describes the observed relation between word length and frequency. In Swedish and English, most word tokens consist of three letters only, while shorter or longer words occur less frequently. We found that the equation with the general form f exp = a * L b * c L (a variant of the so‐called gamma distribution) approximates the observed frequencies reasonably well. This formula incorporates both the fact that the number of possible words increases with word length, and the fact that longer words tend to be avoided, presumably because they are uneconomic. To our knowledge this formula has not been proposed to describe word frequency data. We examined frequency distributions of word length in Swedish and English, and explored different variants of the equation by systematically varying the a, b and c parameters. Subsequently, we also applied the formula to the frequency distribution of sentence length in English, and found an almost perfect fit for a corpus consisting of different text genres. Moreover, the data showed that the formula can be used to distinguish between different kinds of text genres.
Dissecting the labdane‐related diterpenoid biosynthetic gene clusters in rice reveals directional cross‐cluster phytotoxicity (2021)

Rice (Oryza sativa) is a staple food crop and serves as a model cereal plant. It contains two biosynthetic gene clusters (BGCs) for the production of labdane-related diterpenoids (LRDs), which serve important roles in combating biotic and abiotic stress. While plant BGCs have been subject to genetic analyses, these analyses have been largely confined to the investigation of single genes. CRISPR/Cas9-mediated genome editing was used to precisely remove each of these BGCs, as well as simultaneously knock out both BGCs. Deletion of the BGC from chromosome 2 (c2BGC), which is associated with phytocassane biosynthesis, but not that from chromosome 4 (c4BGC), which is associated with momilactone biosynthesis, led to a lesion mimic phenotype. This phenotype is dependent on two closely related genes encoding cytochrome P450 (CYP) mono-oxygenases, CYP76M7 and CYP76M8, from the c2BGC. However, rather than being redundant, CYP76M7 has been associated with the production of phytocassanes, whereas CYP76M8 is associated with momilactone biosynthesis. Intriguingly, the lesion mimic phenotype is not present in a line with both BGCs deleted. These results reveal directional cross-cluster phytotoxicity, presumably arising from the accumulation of LRD intermediates dependent on the c4BGC in the absence of CYP76M7 and CYP76M8, further highlighting their interdependent evolution and the selective pressures driving BGC assembly.