gebhart/patrepeval huggingface dataset:
Network machine learning maps phytochemically rich “Hyperfoods” to fight COVID-19 (2021)

In this paper, we introduce a network machine learning method to identify potential bioactive anti-COVID-19 molecules in foods based on their capacity to target the SARS-CoV-2-host gene-gene (protein-protein) interactome. Our analyses were performed using a supercomputing DreamLab App platform, harnessing the idle computational power of thousands of smartphones. Machine learning models were initially calibrated by demonstrating that the proposed method can predict anti-COVID-19 candidates among experimental and clinically approved drugs (5658 in total) targeting COVID-19 interactomics with the balanced classification accuracy of 80-85% in 5-fold cross-validated settings. This identified the most promising drug candidates that can be potentially "repurposed" against COVID-19 including common drugs used to combat cardiovascular and metabolic disorders, such as simvastatin, atorvastatin and metformin. A database of 7694 bioactive food-based molecules was run through the calibrated machine learning algorithm, which identified 52 biologically active molecules, from varied chemical classes, including flavonoids, terpenoids, coumarins and indoles predicted to target SARS-CoV-2-host interactome networks. This in turn was used to construct a "food map" with the theoretical anti-COVID-19 potential of each ingredient estimated based on the diversity and relative levels of candidate compounds with antiviral properties. We expect this in silico predicted food map to play an important role in future clinical studies of precision nutrition interventions against COVID-19 and other viral diseases.
Nonlinear optical conversion in anisotropic 1D photonic crystal structures (2004)

We fabricate aniostropic porous silicon structures, which exhibit 1-D photonic crystal properties. Both second and third harmonics are generated from these structures. We observe a significant enhancement of nonlinear optical signals from nanoporous materials with respect to crystalline materials. These findings are attributed to the nanocrystalline structure of porous Si. The phase matching of nonlinear optical processes becomes possible in birefringent porous Si structures. The variation of symmetry of the nonlinear optical response from the surface of multilayered anisotropic structures is observed.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Environmental Contamination and Childbirth (2020)

In Brief Patients with asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection give rise to SARS-CoV-2 environmental contamination during childbirth.
Ontogeny of somatostatin mRNA‐containing perikarya in the rat central nervous system (1991)

The distribution of neuronal perikarya containing somatostatin mRNA in the developing rat brain was investigated with in situ hybridization histochemistry. This study describes the expression of somatostatin mRNA during selected perinatal stages and demonstrates regional changes in somatostatin mRNA expression at the single cell level. The mRNA expression closely parallels previously reported developmental localization of the peptide (Inagaki et al., 1982; Shiosaka et al., 1982). As early as embryonic day 13 (E13), somatostatin mRNA was observed in discrete spinal cord and brainstem regions. At birth, densely hybridized somata could be seen primarily in ventral and caudal brain areas with small scattered neurons in the hippocampus and dorsal neocortex. After birth, somatostatin mRNA increased in forebrain regions, such as the hippocampus, dorsal neocortex, and caudate. By postnatal day 14 (P14), the distribution in the telencephalic and diencephalic regions approached that of the adult brain. Several brain regions manifested large changes in the density of somatostatin mRNA hybridization during development. For example, the cerebellar vermis and brainstem contained somatostatin mRNA perikarya during early postnatal development but decreased in these regions in the adult. During perinatal development, increases in somatostatin mRNA content were the results of increases in both the number of neurons containing somatostatin mRNA as well as in the amount of this mRNA expressed in each cell. As the brain differentiates, the apparent numbers of somatostatin mRNA containing neurons in certain brain regions are reduced. These data provide evidence for transient somatostatinergic neurons during early development in discrete areas of the occipital cortex, pyriform cortex, cerebellum, and brainstem and suggest that this peptide may play a role in the development of these regions.
Identification of gonadotroph adenomas in men with clinically nonfunctioning adenomas by the luteinizing hormone beta subunit response to thyrotropin-releasing hormone. (1993)

Because of the recent finding that a majority of clinically nonfunctioning pituitary macroadenomas in women could be identified as of gonadotroph origin by their LH beta-subunit responses to TRH, we evaluated in this study the value of the LH beta-subunit response to TRH in identifying gonadotroph adenomas in men with clinically nonfunctioning macroadenomas. Thirty-eight consecutively studied men with clinically nonfunctioning macroadenomas were given TRH iv, and intact FSH and LH and LH beta- and alpha-subunits were measured every 15 min for 90 min before and 90 min after. TRH tests were also performed on 15 healthy, age-matched control men and on 12 men with adenomas secreting GH or PRL. Of the 38 men with clinically nonfunctioning macroadenomas, basal values were supranormal in 10 for FSH and in 6 each for alpha- and LH beta-subunits. Responses to TRH were elevated, compared to the healthy, age-matched controls, in 14 for LH beta-subunit and in 5 each for intact FSH and LH. None of the men with adenomas secreting GH or PRL exhibited supranormal responses to TRH. Of the 38 clinically nonfunctioning adenomas, 35 were established in dispersed cell culture, and 29 secreted readily detectable amounts of intact FSH, LH, and LH beta-subunit, strongly suggesting that these adenomas were of gonadotroph cell origin. We conclude that the LH beta-subunit response to TRH can identify gonadotroph adenomas in men with clinically nonfunctioning adenomas better than can basal concentrations of intact FSH and alpha-subunit, alone or combined, but not as well as it can in women.
Blockchain Technology for Cloud Storage (2020)

The demand for Blockchain innovation and the significance of its application has inspired ever-progressing exploration in various scientific and practical areas. Even though it is still in the initial testing stage, the blockchain is being viewed as a progressive solution to address present-day technology concerns, such as decentralization, identity, trust, character, ownership of data, and information-driven choices. Simultaneously, the world is facing an increase in the diversity and quantity of digital information produced by machines and users. While effectively looking for the ideal approach to storing and processing cloud data, the blockchain innovation provides significant inputs. This article reviews the application of blockchain technology for securing cloud storage.
Consolidation of Nano-Crystalline Alumina (1996)

Abstract Dense alpha alumina was fabricated from seeded nano-crystalline boehmites. The intrinsic problem of boehmite solubility and hard agglomerate formation was avoided by dispersing gel agglomerates in ethanol. Homogeneous green microstructure and high sintered density were obtained by dry pressing. The superplasticity of nano-crystalline transition alumina was utilized to obtain fully dense, transparent alpha alumina by sinter forging. The effects of seeding and pressure are correlated with the microstructural evolution and densification of alumina.
Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia‐inducible factor 2α (2012)

Hypoxia, via stabilization of HIF2α, regulates the expression of the intestinal iron transporters DMT1 and ferroportin. Here we investigated whether the intestinal copper importer Ctr1 was also regulated by hypoxia. Copper uptake and Ctr1 mRNA expression were significantly increased in Caco-2 cells exposed to hypoxia. To determine whether HIF2α was involved in regulation of Ctr1 expression, we employed three models of HIF2α knockdown (chemical suppression of HIF2α translation in Caco-2 cells; HIF2α-siRNA-treated HuTu80 cells; HIF2α-intestinal knockout mice); Ctr1 mRNA expression was decreased in all three models under normoxic conditions. HIF2α translational inhibitor did not alter Ctr1 expression under hypoxic conditions. We conclude that basal expression of Ctr1 is regulated by HIF2α; however, the induction by hypoxia is a HIF2α-independent event.
Effects of Age and Size on Life Histories and Population Growth of Rhododendron maximum Shoots (1989)

Age- and size-specific shoot life histories were studied with population censuses in June 1984 and June 1985 in an evergreen understory shrub. Rhododendron maximum. Most shoots (65%) survived without branching or flowering, and lesser numbers branched (2%), flowered (20%), or died (23%) during the year between censuses. The probabilities of surviving, branching, flowering or dying were both age- and size-dependent. Small, young shoots increased in leaf area. Flowering occurred most prominently in 3- to 6-year old shoots that had exceeded a leaf area of 200 cm2, and the rate of flowering increased proportionately with size above this threshold. Branching normally occurred in the year following flowering. The age and size distributions of the population shifted significantly between years, indicating a nonequilibrium population. The survival schedule was Deevey Type I, indicating a high degree of “parental care” of young shoots. Age- and age + size-based demographic models predicted a rapid decline of the shoot population over a decade, while a size-based model predicted a much slower decline in shoot numbers. A sensitivity analysis of the models showed that overall shoot population growth was positively influenced by branching shoots and shoots that added leaf area, and negatively influenced by shoots that lost leaf area, died, or flowered. The role of shoot life histories in determining individual plant fitness and ecological dominance is discussed.
Anomalous Phase Inversion in Polymer Blends Prepared by Cryogenic Mechanical Alloying (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTAnomalous Phase Inversion in Polymer Blends Prepared by Cryogenic Mechanical AlloyingArchie P. Smith, Harald Ade, Steven D. Smith, Carl C. Koch, and Richard J. SpontakView Author Information Departments of Materials Science and Engineering, Physics, and Chemical Engineering, North Carolina State University, Raleigh, North Carolina 27695; and Corporate Research Division, The Procter and Gamble Company, Cincinnati, Ohio 45239 Cite this: Macromolecules 2001, 34, 6, 1536–1538Publication Date (Web):February 16, 2001Publication History Received5 July 2000Published online16 February 2001Published inissue 1 March 2001https://pubs.acs.org/doi/10.1021/ma001151phttps://doi.org/10.1021/ma001151prapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views256Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Organic compounds,Polymer morphology,Polymers,Viscosity,X-ray absorption near edge spectroscopy Get e-Alerts
High speed MW-rated induction motor drive system (2017)

Multi-physics design, simulation and analysis studies on an induction motor drive system rated 1 MW 15,000 RPM 4160 V are presented. Component level manufacturability and materials selection have been performed for the high speed application. Litz wire stator coils have been designed to reduce high frequency proximity losses. Prototype stator coils have been manufactured and tested. The various components of the system have been verified experimentally by bench tests. A novel power electronic drive using high power silicon carbide devices for the high speed application is developed. The complete motor and drive are now being manufactured for full load testing with the new dynamometer system at the eGrid Center of Clemson University.
Chicory extract’s influence on gut bacteria of abdominal obesity rat (2014)

To investigate the efficacy mechanisme of chicory extract interventing abdominal obesity rat from the aspect of gut bacteria.
The AIDS Knowledge Base: A Textbook on HIV Disease From the University of California, San Francisco, and the San Francisco General Hospital (1990)

The editors and authors of this large text are extremely familiar with the problems of the acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV) infection. The book reviews the epidemiology, transmission, testing, natural history, and management of HIV and of the infections associated with AIDS. There is extensive review of the social, legal, and public policy issues surrounding HIV and AIDS. Education and prevention strategies are presented. An extensive bibliography accompanies every chapter with references in many as recent as 1989. Most of the treatment options are up-to-date. Indeed, in the section on zidovudine, the data reflect many of the current concepts on use in patients with CD4 counts below 200 and below 500. It is quite easy to look up specific problems in this text, and although there are almost daily changes depending on the latest issues of the widely quoted medical journals, the basics are present. Such
Modeling Business Insights into Predictive Analytics for the Outcome of IT Service Contracts (2015)

The chances of winning highly valued Information Technology (IT) service contracts are influenced by various factors. Identifying key factors driving the competition and the early prediction of the outcome (either winning or losing such sales opportunities) can have significant business benefits. Given the complexity of IT services, range of potential attributes, and scarcity of comparable data sets, the straightforward approach of developing predictive analytical models that works well in other industries, such as consumer products, tends to achieve lower accuracy in this context. In this paper, we develop an approach that uses business insights and domain knowledge in the classification of several of the attributes influencing the outcome. We show how using this approach in a naïve Bayes predictive analytics framework can vastly improve the prediction accuracy. Further, we discuss two applications of our model, early prioritization of newly validated sales opportunities and optimization of sales force allocation and planning.
Energy Consumption of an LS Excavator Hydraulic System (2007)

This paper presents the results of a simulation study regarding the energy consumption of a load-sensing excavator hydraulic system and discusses the possible energy savings by eliminating the directional control valves. The energy consumption of the excavator hydraulic system has been studied for typical working cycles. For this purpose a coupled multi-body dynamics and hydraulic system model was developed in the Matlab Simulink environment, including a precise measurement-based loss model of the variable displacement pump. Power transmission and dissipation was calculated for each component and subsystem, including pumps, motors, valves, cylinders, transmission lines, and others. The simulation results show the amount of dissipated energy, indicating the major loss sources during various operations. Furthermore, the potential recoverable energy in the cycle is calculated, highlighting the prospective advantages of equipping the existing machine with new pump-controlled actuator technology.
Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase. (1993)

Leukotriene B4 (LTB4) 12-hydroxydehydrogenase was purified to apparent homogeneity from the cytosol fraction of the porcine kidney. The N-terminal amino acid sequence analysis revealed that this enzyme is a novel protein with a molecular weight of 35,000. Although the enzyme is ubiquitously distributed in various tissues and leukocytes of porcine, the kidney and liver had the highest enzyme activities. In the presence of NADP+ as a cofactor, the enzyme catalyzes the conversion of LTB4 to 12-oxo-LTB4, the structure identified by gas chromatography/mass spectrometry. 12-Oxo-LTB4 was further converted by other enzymes to 10,11,14,15-tetrahydro-12-oxo-LTB4, which was determined by proton NMR and gas chromatography/mass spectrometry. 12-Oxo-LTB4 was 100-fold less potent than LTB4 in increasing intracellular calcium concentrations of human leukocytes. 6-trans-LTB4 and LTB4 proved to be the best substrates of the enzyme, whereas various types of monohydroxyeicosatetraenoic acids, 5(S),12(S)-dihydroxyeicosatetraenoic acid, prostaglandins, cortisol, or pregnenolone could not serve as a substrate. These results suggest that the enzyme acts specifically on the 12(R)-hydroxy group of leukotriene B4 and is involved in the metabolic inactivation of LTB4 in the porcine kidney.
Customer Communication Management: the Case Study of the Italian Employment Information System (2006)

The purpose of this paper is to show how the use of a Customer Communication Management system can be inserted into the Italian Employment Information System (EMPL-IS). Such system, framed into the Italian Plan of eGovernment, is intended to explore, process and automatically match job vacancies and offers in the National Job Workfare. The Italian EMPL-IS belongs to the National and Local Public Administrations (specifically Regions and Provinces). Since Public Administrations, differently from enterprises and other business entities, can not choose their customers, customer care deserves special attention. Therefore, effective customer care can be achieved through Customer Relationship Management techniques. This paper presents how information gained from the customers¿ opinions can be used as a powerful instrument to tune the system and to obtain a constructive user feedback to improve actual service delivery.
Benut jou tyd doeltreffend (2003)

Hierdie artikel deur Hettie Smit van Potchefstroom het in Die Gereformeerde Vroueblad van Februarie 2001 verskyn. Met die skrywer se toestemming plaas ons dit in hierdie uitgawe van Die Kerkblad. (In die Maart 2001-uitgawe van die Vroueblad het die skrywer wenke vir effektiewe tydsbenutting gegee, maar weens beperkte ruimte volstaan ons met hierdie bydrae.)
Linearized segmentation method for measuring the phase transfer function of a silicon Mach–Zehnder modulator by using the beat-frequency technique (2020)

A linearity segmentation method for measuring the phase shift curve of silicon Mach-Zehnder modulators (SMZMs) as a function of applied electric field is presented. Applying a small sinusoidal signal to the traveling-wave electrode of the SMZM, the upper and lower arms of the SMZM produce differential phase modulation effect. Meanwhile, a local oscillator source with a wavelength-adjustable function is employed to heterodyne the intensity modulated optical signal of the SMZM; thus, the modulated intensity signal in the optical field domain is transformed into the low-frequency electric field domain. Meanwhile, a balanced detector with a low-speed transimpedance amplifier is exploited to realize photoelectric conversion, which can suppress the direct-current component and improve the anti-noise ability. Extracting the beat-frequency and first-order harmonic sideband signals in the case of phase bias is 0 and <i>π</i>, respectively, the phase shift slopes of the upper and lower arms can be calculated under different reverse PN voltages, and we can achieve the phase shift as a function of the modulation frequency and reverse PN voltage. The proposed method is supported by the simulation and measurement results and the key parameters of the SMZM, such as the radio frequency half-wave voltage, chirp characteristic, 3 dB bandwidth, etc., can be acquired from the phase shift curves of the upper and lower arms.
Improved Outcomes of Haploidentical Hematopoietic Cell Transplantation with Total Body Irradiation-Based Myeloablative Conditioning in Acute Lymphoblastic Leukemia (2020)

The optimal myeloablative conditioning (MAC) for patients undergoing haploidentical hematopoietic cell transplantation (haplo-HCT) is unknown. We studied the outcomes of total body irradiation (TBI)-based versus chemotherapy (CT)-based MAC regimens in patients with acute lymphoblastic leukemia (ALL). The study included 427 patients who underwent first haplo-HCT with post-transplantation cyclophosphamide (PTCy), following TBI-based (n = 188; 44%) or CT-based (n = 239; 56%) MAC. The median patient age was 32 years. Fludarabine-TBI (72%) and thiotepa-busulfan-fludarabine (65%) were the most frequently used TBI- and CT-based regimens, respectively. In the TBI and CT cohorts, 2-year leukemia-free survival (LFS) was 45% versus 37% (P = .05), overall survival (OS) was 51% versus 47% (P = .18), relapse incidence (RI) was 34% versus 32% (P = .44), and nonrelapse mortality (NRM) was 21% versus 31% (P < .01). In the multivariate analysis, TBI was associated with lower NRM (hazard ratio [HR], 0.53; 95% confidence interval [CI], 0.33 to 0.86; P = .01), better LFS (HR, 0.71; 95% CI, 0.52 to 0.98; P =.04), and increased risk for grade II-IV acute graft-versus-host disease (GVHD) (HR, 1.59; 95% CI, 1.08 to 2.34; P = .02) compared with CT-based MAC. The type of conditioning regimen did not impact RI, chronic GVHD, OS, or GVHD-free, relapse-free survival after adjusting for transplantation-related variables. TBI-based MAC was associated with lower NRM and better LFS compared with CT-based MAC in patients with ALL after haplo-HCT/PTCy.
The Future of Augmented Reality Gaming (2007)

Entertainment systems are one of the successful utilisations of augmented reality technologies to real world applications. This chapter provides my personal insights into the future directions of the use of augmented reality with gaming applications. This chapter explores a number of advances in technologies that may enhance augmented reality gaming. The features for both indoor and outdoor augmented reality are examined in context of their desired attributes for the gaming community. A set of concept games for outdoor augmented reality are presented to highlight novel features of this technology.