gebhart/patrepeval huggingface dataset:
Detection of specific nitrogen-containing compounds by room-temperature phosphorescence (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetection of specific nitrogen-containing compounds by room-temperature phosphorescenceDavid W. Abbott and Tuan. Vo-DinhCite this: Anal. Chem. 1985, 57, 1, 41–45Publication Date (Print):January 1, 1985Publication History Published online1 May 2002Published inissue 1 January 1985https://doi.org/10.1021/ac00279a015RIGHTS & PERMISSIONSArticle Views126Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (661 KB) Get e-Alerts Get e-Alerts
A calculus for network delay. I. Network elements in isolation (1991)

A calculus is developed for obtaining bounds on delay and buffering requirements in a communication network operating in a packet switched mode under a fixed routing strategy. The theory developed is different from traditional approaches to analyzing delay because the model used to describe the entry of data into the network is nonprobabilistic. It is supposed that the data stream entered into the network by any given user satisfies burstiness constraints. A data stream is said to satisfy a burstiness constraint if the quantity of data from the stream contained in any interval of time is less than a value that depends on the length of the interval. Several network elements are defined that can be used as building blocks to model a wide variety of communication networks. Each type of network element is analyzed by assuming that the traffic entering it satisfies bursting constraints. Under this assumption, bounds are obtained on delay and buffering requirements for the network element; burstiness constraints satisfied by the traffic that exits the element are derived.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Structural and dynamical analysis of integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19 (2020)

Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by the new coronavirus (SARS-CoV-2) is currently responsible for over 500 thousand deaths in 216 countries across the world and is affecting over 10 million people. The absence of FDA approved drugs against the new SARS-CoV-2 virus has highlighted an urgent need to design new drugs. We developed an integrated model of the human cell and the SARS-CoV-2 virus to provide insight into the pathogenetic mechanism of the virus and to support current therapeutic strategies. We show the biochemical reactions required for the growth and general maintenance of the human cell, first of all, in its healthy state. We then demonstrate how the entry of the SARS-CoV-2 virus into the human cell causes biochemical and structural changes, leading to a change of cell functions or cell death. We have completed a comparative analysis of our model and other previously generated cell type models and highlight 48 pathways and over 800 reactions hijacked by the virus for its replication and survival. We designed a new tool which predicts 15 unique reactions as drug targets from our models (the integrated human macrophage, human airway epithelial cells and the SARS-CoV2 virus) and provide a platform for future studies on viral entry inhibition and drug optimisation strategies.
The vascular endothelium in chronic renal failure. (2000)

Chronic renal failure (CRF) is associated with a 20-fold increased risk of cardiovascular death, two principal mechanisms being: sudden, arrhythmic death associated with left ventricular hypertrophy, and ischaemic heart disease, associated with accelerated atherosclerosis. In recent years, the vascular endothelium has been recognised as a large and complex endocrine organ, with many important physiological functions including the control of vascular tone. Endothelial dysfunction, commonly characterised by reduced production of the vasodilator nitric oxide (NO), is thought to be a key initial event in the development of atherosclerosis and is present in patients with hypertension and hyperlipidaemia. While these cardiovascular risk factors are also prevalent in CRF, other factors more specific to uraemia such as accumulation of homocysteine and asymmetric dimethylarginine (endogenous inhibitor of NO synthase) may impair endothelial function. Modulation of endothelial function in CRF may offer a novel strategy to reduce cardiovascular disease.
Use and Work Scope of Oral Health Assistance Personnel as Perceived by Dentists (2012)

The objective of this study was to identify the current status of use and respective work scopes of dental hygienists and nursing assistants as perceived by dentists, thereby obtaining a model for how to efficiently use oral health assistance personnel. This study was based on a self-reported survey administered to a total of 126 dentists. The following findings were observed. Where competition among neighborhood clinics was relatively high, nursing assistants tended to be used as a resource to assist dental hygienists, whereas where it was relatively low, they were more likely to be considered to work as full substitutes for regular dental hygienists. Looking at the scopes of practice, dental hygienists were allowed to deal with matters of preventive care, oral health education, and health insurance claims. On the other hand, nursing assistants were allowed to be in charge of taking X-ray pictures from the outside and inside of mouth and keeping medical devices clean and safe. This study is expected to contribute to establishing more reasonable oral heath personnel structure design decisions.
Valorization of Agri-Food Wastes as Sustainable Eco-Materials for Wastewater Treatment: Current State and New Perspectives (2021)

The paper addresses environmental protection by valorizing an important agri-food waste category, namely fruit and vegetables with focusing on the main characteristics regarding consumption, waste quantities, and ways for valorizing these materials. Thus, vast research was undertaken in order to emphasize the main commodities and their potential application as adsorbents for organic and inorganic pollutants. The main methods or treatment techniques applied for the valorization of eco-materials as adsorbents were presented and the principal efficiency results were indicated. The advantages and disadvantages of using these eco-materials as adsorbents in wastewater treatment were revealed and future recommendations were established. According to the international statistics, the most purchased and consumed five commodities were studied regarding waste generations as potential conversion into eco-materials with an adsorbent role for water pollutants. Thus, the performances for adsorbents based on fruit wastes (such as citrus, banana, apples, grapes, mango) and vegetable wastes (such as potatoes, tomatoes, cabbage, carrots, cauliflower, and/or broccoli) were studied and highlighted in this research.
A Preliminary Virtual Study on the Feasibility of Transferring Muscular Activation Pattern Behaviors of Psychomotor Exercises (2023)

Research has demonstrated that Taekwondo training helps to enhance the coordination capabilities in people with developmental coordination disorders. These excellent results depend on many factors, including the behavior of the muscular activation patterns of psychomotor exercises during Taekwondo training. Our basic idea is to study the behavior of the muscular activation pattern of Taekwondo training (performed by athletes) and to apply the adapted behavior of the muscular activation pattern to other subjects with reduced coordination capabilities to enhance them, in line with the sustainable human development goals. This paper presents a preliminary feasibility study and a first step in this direction using a virtual simulation. First, the Taekwondo front-kick exercise was studied and reproduced using a virtual human model in OpenSim. Second, some perturbations were applied to the virtual human model to analyze the behavior of the muscular activation patterns. Third, functional electrical stimulation (FES) patterns were properly simulated to reproduce the same sequence (and value) of signals of muscular activation in another subject. The proposed methodology was conceived on the basis of a simple example of a Taekwondo kick by using a virtual human model, but its general application can fit all kinds of psychomotor exercises. If future works confirm the simulation results presented in this paper with real implementation, the methodology proposed here could be applied every time human capabilities must be increased with or without sports training (e.g., remaining seated on a chair or lying on a bed).
IL-3 Inhibits TNF-α-Induced Bone Resorption and Prevents Inflammatory Arthritis (2009)

IL-3, a cytokine secreted by activated T cells is well known to regulate the proliferation, differentiation, and survival of pluripotent hematopoietic stem cells. IL-3 functions as a link between the immune and the hematopoietic system. In this study, we suggest an important new role of IL-3 in inhibition of TNF-alpha-induced bone resorption in vitro and prevention of inflammatory arthritis in mice. We show here that IL-3 potently and irreversibly inhibits TNF-alpha-induced bone resorption in hematopoietic precursors of monocyte/macrophage lineage. IL-3 showed an inhibitory effect on TNF-alpha-induced bone resorption even in the presence of proinflammatory cytokines such as IL-1alpha, TGF-beta(1), TGF-beta(3), IL-6, and PGE(2). We found that IL-3 prevented TNF-alpha-induced c-fos nuclear translocation and AP-1 DNA-binding activity. Interestingly, IL-3 pretreatment prevented the development of inflammatory arthritis in mice induced by a mixture of anti-type II collagen mAbs and LPS. Furthermore, IL-3 prevented cartilage and bone loss in the joints indirectly through inhibition of inflammation. Thus, we provide the first evidence that IL-3, a strong regulator of hematopoiesis, also plays an important role in inhibition of TNF-alpha-induced bone resorption and prevention of inflammatory arthritis in mice.
Research on Danjiang Water Quality Prediction Based on Improved Artificial Bee Colony Algorithm and Optimized BP Neural Network (2021)

In order to ensure “a river of clear water is supplied to Beijing and Tianjin” and improve the water quality prediction accuracy of the Danjiang water source, while avoiding the local optimum and premature maturity of the artificial bee colony algorithm, an improved artificial bee colony algorithm (ABC algorithm) is proposed to optimize the Danjiang water quality prediction model of BP neural network is proposed. This method improves the local and global search capabilities of the ABC algorithm by adding adaptive local search factors and mutation factors, improves the performance of local search, and avoids local optimal conditions. The improved ABC algorithm is used to optimize the weights and thresholds of the BP neural network to establish a water quality grade prediction model. Taking the water quality monitoring data of Danjiang source (Shangzhou section) from 2015 to 2019 as the research object, it is compared with GA-BP, PSO-BP, ABC-BP, and BP models. The research results show that the improved ABC-BP algorithm has the highest prediction accuracy, faster convergence speed, stronger stability, and robustness.
REVIEW OF U.S. ENVIRONMENTAL PROTECTION AGENCY RESEARCH IN OIL-WATER SEPARATION TECHNOLOGY (1975)

ABSTRACT The U.S. Environmental Protection Agency has sponsored two separate research contracts in the field of oil-water separation for the fiscal year 1974. One project, with Pollution Abatement Research, Inc., of Dallas, Texas, concerns the development of a chemically assisted, back-washable coalescer with chemically assisted backwash solids scrubber. This device is designed for use on offshore oil production platforms, although it has a wide potential of applicability. Preliminary tests made with large-volume samples of produced water from an offshore oil production platform yielded very promising results with less than 10 ppm produced oil in the effluent water. The second project, with the Ben Holt Company of Pasadena, California, is to develop a new concept of adsorption of oil-contaminated water onto a regenerable coked surface. The project is aimed at chemically stabilized emulsions and dissolved oils. A bench-scale device has been built, and testing has proven the feasibility of the concept. The rationale for the development of each of these devices is presented along with detailed information concerning test results of each device.
Mind Wandering While Driving (2015)

Distracted driving has been identified as a major concern in highway safety. Research to-date, however, has largely focused on distraction related to external events or intentional engagement in non-driving activities. Internal distraction (“mind wandering”) is now being recognized as a significant source of driver distraction that requires rigorous study. There are substantial challenges in detecting, measuring, and addressing mind wandering while driving. Panelists with expertise in driver distraction in general, and mind wandering in particular, will discuss both scientific and pragmatic issues in addressing this problem. Each panelist will present a brief perspective on the problem from the point of view of their experience and expertise. This will be followed by an open discussion period.
Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation and Function by Mitogen-activated Protein Kinase (1997)

Increased serine phosphorylation of insulin receptor substrate-1 (IRS-1) has been observed in several systems to correlate with a decreased ability of the insulin receptor to tyrosine-phosphorylate this endogenous substrate and to inhibit its subsequent association with phosphatidylinositol 3-kinase. In the present studies we have examined the potential role of the mitogen-activated protein (MAP) kinase in the increased serine phosphorylation of IRS-1 observed in human embryonic kidney cells treated with an activator of protein kinase C, phorbol 12-myristate 13-acetate. First, recombinantly produced kinase was shown to phosphorylate intact IRS-1 in a way that decreased the ability of isolated insulin receptor to phosphorylate the tyrosines recognized by the SH2 domains of the phosphatidylinositol 3-kinase. Second, an inhibitor of MAP kinase activation, PD98059, blocked the phorbol 12-myristate 13-acetate-induced inhibition of the insulin-stimulated increase in IRS-1 associated phosphatidylinositol 3-kinase. Third, activation of MAP kinase in intact cells via a regulatable upstream kinase, a RAF:estrogen receptor construct, could also inhibit the insulin-stimulated increase in IRS-1-associated phosphatidylinositol 3-kinase. Fourth, an in gel kinase assay showed that MAP kinase was the primary renaturable kinase in cell extracts capable of phosphorylating an IRS-1 fusion protein. Finally, IRS-1 was found to associate in coprecipitation studies with endogenous MAP kinase. These studies implicate MAP kinase as one of the kinases capable of phosphorylating and regulating IRS-1 tyrosine phosphorylation.
Investigation of significant inputs for pavement rehabilitation design in the Pavement-ME (2018)

The Pavement-ME can design different flexible or rigid pavement rehabilitation scenarios. A set of quantitative and qualitative input variables are considered to characterize the new and existing pavement layers and predict the damage accumulation in these layers. To evaluate the impact of the inputs on the predicted performance for the rehabilitation options, sequential analyses were performed to assess the main and interactive effects of each input. Continuous responses surface models for interactive effects were obtained using artificial neural network. Furthermore, a normalized sensitivity index was used to quantify the significance of main and interactive effects. The following rehabilitation options were included in this paper: hot mix asphalt (HMA) over HMA, HMA over jointed plain concrete pavement (JPCP), HMA over fractured JPCP, and JPCP over JPCP. The results of the study can assist the highway agencies’ efforts to implementing the Pavement-ME, especially when the majority of pavement designs are related to rehabilitation of the existing highways.
Metritis en endometritis bij hoogproductief melkvee (2009)

Since a few decades, dairy cows have shown a steep increase in milk production, which is unfortunately accompanied by a dramatic decline in reproductive performance. In these high yielding cows there are more puerperal problems than in low yielding cows, such as retained placenta, acute metritis and abnormal vaginal discharge. Cows affected by retained placenta and/or acute metritis are furthermore at a significantly higher risk of other typical ‘dairy cow diseases’ as acetonaemia, left displaced abomasum and cystic ovarian disease. Therefore it is important that puerperal metritis is treated properly with broadspectrum antibiotics both parenterally and intra-uterine during 1 – 3 days depending on the severity of the symptoms. Cows with chronic endometritis need no treatment before 30 days post partum. From day 30 on they should be treated twice with prostaglandins at an interval of 14 days. A challenge for the future is to clearly determine all risk factors for uterine disease. One of the major risk factors is a retained placenta. Correct nutrition during the dry off period and a normal calving process under hygienic conditions are the paramount factors in the prevention of this risk factor.
Deep X‐Ray Imaging of the Central 20 Parsecs of the Galaxy with Chandra (2003)

This chapter contains sections titled: Introduction The Bipolar Lobes The Cometary Source, CXOGC 5174539.7-290020
Diffuse Optical Tomography of the Breast: Initial Validation in Benign Cysts (2008)

DOT can visualize benign cysts in the breast and elucidate their high water and low total hemoglobin content by spectroscopic analysis.
Heuristic approaches to the design of a cybernetic electroanalytical instrument (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHeuristic approaches to the design of a cybernetic electroanalytical instrumentHari GunasinghamCite this: J. Chem. Inf. Comput. Sci. 1986, 26, 3, 130–134Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/ci00051a008https://doi.org/10.1021/ci00051a008research-articleACS PublicationsRequest reuse permissionsArticle Views29Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Heat Treatment Effect on the Metal Contact of High-Tc(Pb, Bi)SrCaCuO Superconductor (1991)

Better metal electrode can be obtained by heat treatment which causes deeper diffusion of metal particles into the (Pb, Bi)SrCaCuO superconductor to improve contacts between metal electrodes and the sample. However, high- T c phase of the specimen was destroyed at 700°C and the sample showed semiconducting behaviour. Low room temperature contact resistivity was obtained about 3.21×10 -4 (Ω-cm 2 ) and 2.34×10 -6 (Ω-cm 2 ) at 77 K for a sample with evaporating silver electrodes and annealed at 600°C for 2 hours. Non-ohmic contacts are observed for the indium and aluminum terminals.
FORMS: Fine-grained Polarized ReRAM-based In-situ Computation for Mixed-signal DNN Accelerator (2021)

Recent work demonstrated the promise of using resistive random access memory (ReRAM) as an emerging technology to perform inherently parallel analog domain in-situ matrix-vector multiplication—the intensive and key computation in deep neural networks (DNNs). One key problem is the weights that are signed values. However, in a ReRAM crossbar, weights are stored as conductance of the crossbar cells, and the in-situ computation assumes all cells on each crossbar column are of the same sign. The current architectures either use two ReRAM crossbars for positive and negative weights (PRIME), or add an offset to weights so that all values become positive (ISAAC). Neither solution is ideal: they either double the cost of crossbars, or incur extra offset circuity. To better address this problem, we propose FORMS, a fine-grained ReRAM-based DNN accelerator with algorithm/hardware co-design. Instead of trying to represent the positive/negative weights, our key design principle is to enforce exactly what is assumed in the in-situ computation— ensuring that all weights in the same column of a crossbar have the same sign. It naturally avoids the cost of an additional crossbar. Such polarized weights can be nicely generated using alternating direction method of multipliers (ADMM) regularized optimization during the DNN training, which can exactly enforce certain patterns in DNN weights. To achieve high accuracy, we divide the crossbar into logical sub-arrays and only enforce this property within the fine-grained sub-array columns. Crucially, the small sub-arrays provides a unique opportunity for input zero-skipping, which can significantly avoid unnecessary computations and reduce computation time. At the same time, it also makes the hardware much easier to implement and is less susceptible to non-idealities and noise than coarse-grained architectures. Putting all together, with the same optimized DNN models, FORMS achieves 1.50× and 1.93× throughput improvement in terms of $\frac{{GOPs}}{{s \times m{m^2}}}$ and $\frac{{GOPs}}{W}$ compared to ISAAC, and 1.12× ~2.4 × speed up in terms of frame per second over optimized ISAAC with almost the same power/area cost. Interestingly, FORMS optimization framework can even speed up the original ISAAC from 10.7 × up to 377.9×, reflecting the importance of software/hardware co-design optimizations.