gebhart/patrepeval huggingface dataset:
Concepts of mild memory impairment in the elderly and their relationship to dementia—a review (1992)

Abstract The concept enshrined by Kral (1962) in the term ‘benign senescent forgetfulness’ is reviewed together with a number of other diagnostic terms synonymous with mild memory impairment. Data from epidemiological studies which employ them are presented and the relationship between ‘normal’ ageing, subjective memory complaints and dementia is discussed. Mild memory impairment in late life is associated with an increased risk of developing dementia but it is difficult from present studies to quantify this.
Effects of mirror surface roughness on exposure field uniformity in synchrotron x-ray lithography (1991)

In this paper we discuss the surface roughness tolerances for mirrors used in synchrotron x-ray lithography beamlines. These requirements are different for lithography beamlines than they are for traditional beamlines, which are imaging systems. For imaging optical systems it is desirable to minimize the surface roughness of the mirror in order to reduce the intensity of the scattered light. Proximity print x-ray lithography requires nonimaging optical systems designed to deliver a uniform power distribution at the exposure field. In such applications, the scattering of x rays is less important, provided that the total flux is not too severely degraded. From this point of view it is important to notice that scattering removes power from the central, coherent, beam and redistributes it over a wider angle. The loss in reflectivity is only apparent because energy is conserved in the process. Furthermore, the presence of scattered x rays can be used to improve the uniformity of the power distribution. The requirement on the surface quality of mirrors used for scanning x-ray illumination is thus relaxed with respect to that of typical imaging systems, providing considerable cost savings and simplifying manufacturing. The effect of the scattered light on the uniformity of illumination is dependent on intensity and angular distribution of the scattering. Experimental results will be compared to the results predicted by calculations.
Prognostics Method for Analog Electronic Circuits (2012)

&#x0D; &#x0D; &#x0D; Analog electronic circuits are an integral part of many industrial systems. Failure in such analog circuits during field operation can have severe economic implications. The presence of an expert system that can provide advance warnings on circuit failures can minimize the downtime and improve the reliability of electrical systems. Through successive refinement of circuit’s response to a sweep signal, features are extracted for fault prognosis. From the extracted features, a fault indicator is developed. An empirical model is developed based on the degradation trend exhibited by the fault indicator. Particle filtering approach is used for model adaptation and remaining useful performance estimation. This framework is completely automated and has the merit of implementation simplicity. The proposed framework is demonstrated on two analog filter circuits.&#x0D; &#x0D; &#x0D;
Canada in World Affairs. XI. 1959 to 1961 (1966)

Find information about UTP Journals. University of Toronto Press is Canada’s leading academic publisher and one of the largest university presses in North America, with particular strengths in the social sciences, humanities, and business. The Book Publishing Division is widely recognized in Canada for its strength in history, political science, sociology, Indigenous studies, and cultural studies. Internationally, UTP is a leading publisher of medieval, Renaissance, Italian, Iberian, Slavic, and urban studies, as well as studies in book and print culture.
Heat Transfer in a Complex Trailing Edge Passage for a High Pressure Turbine Blade: Part 1 — Experimental Measurements (2002)

A combined experimental and computational study has been performed to investigate the detailed heat transfer coefficient distributions within a complex blade trailing edge passage. The experimental measurements are made using a steady liquid crystal thermography technique applied to one major side of the passage. The geometry of the trailing edge passage is that of a two-pass serpentine circuit with a sharp 180-degree turning region at the tip. The upflow channel is split by interrupted ribs into two major sub-channels, one of which is turbulated. This channel has an average aspect ratio of roughly 14:1. The spanwise extent of the channel geometry includes both area convergence from root to tip, as well as taper towards the trailing edge apex. The average section Reynolds numbers tested in this upflow channel range from 55,000 to 98,000. The tip section contains a turning vane near the extreme corner. The downflow channel has an aspect ratio of about 5:1, and also includes convergence and taper. Turbulators of varying sizes are included in this channel also. Both detailed heat transfer and pressure distribution measurements are presented. The pressure measurements are incorporated into a flow network model illustrating the major loss contributors.
ADAM‐HCV, a new‐concept diagnostic assay for antibodies to hepatitis C virus in serum (2001)

We screened phage libraries using sera from noninfected individuals and patients infected by hepatitis C virus (HCV). By applying different selection and maturation strategies, we identified a wide collection of efficient phage-borne ligands for HCV-specific antibodies. The selected ligands retained their antigenic properties when expressed as multimeric synthetic peptides. Peptides that mimic several immunodominant epitopes of the virus were used to develop a novel type of diagnostic assay which efficiently detects antibodies to HCV in serum. This type of analysis provides a conclusive diagnosis for many patients identified as indeterminate according to presently available serological assays.
Microwave Dielectric Behavior of Wet Soil-Part 1: Empirical Models and Experimental Observations (1985)

This is the first paper in a two-part sequence that evaluates the microwave dielectric behavior of soil-water mixtures as a function of water content, temperature, and soil textural composition. Part I presents the results of dielectric constant measurements conducted for five different soil types at frequencies between 1.4 and 18 GHz. Soil texture is shown to have an effect on dielectric behavior over the entire frequency range and is most pronounced at frequencies below 5 GHz. In addition, the dielectric properties of frozen soils suggest that a fraction of the soil water component remains liquid even at temperatures of -24° C. The dielectric data as measured at room temperature are summarized at each frequency by polynomial expressions dependent upon both the volumetric moisture content m and the percentage of sand and clay contained in the soil; separate polynomial expressions are given for the real and imaginary parts of the dielectric constant. In Part II, two dielectric mixing models will be presented to account for the observed behavior: 1) a semiempirical refractive mixing model that accurately describes the data and requires only volumetric moisture and soil texture as inputs, and 2) a theoretical four-component mixing model that explicitly accounts for the presence of bound water.
Optimising recognition rates for subject independent gait pattern classification (2009)

This paper describes a study which was carried out to determine an optimally performing classification algorithm for the problem of subject independent gait pattern classification. The study utilised a frequency domain based feature vector based on the concept of cepstral coefficients whose generation methodology was optimised in terms of overall system recognition rates. The performance of a number of both linear and nonlinear classification algorithms including neural network and Support Vector Machines was examined. An optimal recognition rate of 78.4±3.2% was achieved using a one-versus-all MLP classier applied to a previously unseen test database of 12 subjects completing ten repetitions of five different human gait patterns including walking on level surfaces, walking up and down stairs and walking up and down ramps. (6 pages)
Lacceryl laccerate: major wax component produced by Anomoneura mori Schwarz (Homoptera: Psyllidae). (1980)

The major wax component secreted by Anomoneura mori Schwarz nymph was identified as lacceryl laccerate, n-dotriacontyl n-dotriacontanoate. Its content in the wax was 93.8%.
Formalization and Analysis of a Resource Allocation Security Protocol for Secure Service Migration (2018)

The advent of virtual machine technology for example, VMware, and container technology, such as Docker, have made the migration of services between different Cloud Systems possible. This enables the development of mobile services that can ensure low latencies between servers and their mobile clients resulting in better QOS. Though there are many mechanisms in place to support for mobile services, a key component that is missing is the development of security protocols that allow the safe transfer of servers to different Cloud environments. In this paper, we propose a Resource Allocation Security Protocol for secure service migration. We explore two approaches; In the first approach, the protocol is developed and formally verified by Automated Validation of Internet Security Protocols and Applications tool. The protocol satisfies the security properties of secrecy and authentication. In addition, nonces are used for replay protection and to ensure freshness. In the second approach, a secure symmetrical session key is used to do the safe transfer and an automatic cryptographic protocol verifier ProVerif is employed to verify secrecy, authentication and key exchange.
Immune complex enhances tolerogenecity of immature dendritic cells via FcγRIIb and promotes FcγRIIb‐overexpressing dendritic cells to attenuate lupus (2011)

A balance of inhibitory and activating signals determines the function of dendritic cells (DCs) in the immune response, which may be regulatory or stimulatory. Defects of inhibitory receptor FcγRIIb are involved in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE), in which high levels of circulating immune complexes (IC) exist. Our previous study showed that IC/Ig can suppress TLR4-triggered inflammatory responses in macrophages via FcγRIIb. This led us to question whether IC/Ig can polarize FcγRIIb-overexpressing DCs (DC-FcγRIIb) to be tolerogenic, thus attenuating lupus progression once infused in vivo. First, we found that IC/Ig markedly inhibited LPS- or CpG-induced DC maturation, enhanced tolerogenicity of DCs via FcγRIIb, and induced massive prostaglandin E2 (PGE2) secretion from DCs, both contributing to T-cell hyporesponsiveness. Endogenous Ig and lupus-derived IC also exhibited the same effect. DC-FcγRIIb, transfected with recombinant adenovirus encoding FcγRIIb, displayed enhanced tolerogenic function and produced more PGE2 in the presence of IC, thus further inhibiting T-cell responses. Importantly, in vivo infusion with DC-FcγRIIb significantly reduced kidney damage and prolonged the survival of lupus-prone MRL/lpr mice either before or after the onset of clinic lupus. Therefore, administration of DC-FcγRIIb may be a new approach to attenuate lupus progression.
Tahiti Field: Assessment of Uncertainty in a Deepwater Reservoir UsingDesign of Experiments (2006)

Tahiti prospect in deepwater Gulf of Mexico is a three-way anticlinal structure trapped against salt, with primary pay sands ranging from 24,000 to 27,000 ft TVD. The field contains several hydrocarbon-bearing turbidite sands. The discovery well was drilled in 2002, and two appraisal wells were drilled soon afterwards. Due to significant uncertainties remaining after appraisal, probabilistic methods were used to assess development plan alternatives and reserves. The primary purpose of this paper is to show the integrated earth modeling and reservoir simulation workflow, which incorporates uncertainty analysis and experimental design.The first step of the reservoir simulation workflow was the identification of the uncontrollable parameters that might influence performance predictions. These uncontrollable parameters included the earth model, water-oil contact location, faulting and compartmentalization, reservoir anisotropy, aquifer support, relative permeability curves, pore volume compressibility, rock compaction and dilation, fluid characterization, skin factor and well pressure drawdown. The analysis of available information from Tahiti field and analog fields with simple statistical techniques allowed the unbiased estimation of low, medium and high values of each uncontrollable parameter. The second step was the application of design of experiments to evaluate the impact of each uncertainty on reservoir performance. Monte Carlo simulation was used to estimate P10, P50 and P90 oil recovery and discounted oil recovery for each reservoir. Finally, we developed reasonable P10, P50 and P90 reservoir simulation models that incorporate the full range of each significant reservoir uncertainty.Probabilistic production forecasts for primary depletion and waterflood strategies supported project decisions like number of pre-drills, total well count, bottom-hole locations, waterflood strategies and facility capacity. Reservoir simulation results also supported proved reserves estimation and economic evaluation of the project.
The Transport of Choline (2002)

Choline has many physiological functions throughout the body that are dependent on its available local supply. However, since choline is a charged hydrophilic cation, transport mechanisms are required for it to cross biological membranes. Choline transport is required for cellular membrane construction and is the rate-limiting step for acetylcholine production. Transport mechanisms include: (1) sodium-dependent high-affinity uptake mechanism in synaptosomes, (2) sodium-independent low-affinity mechanism on cellular membranes, and (3) unique choline uptake mechanisms (e.g., blood-brain barrier choline transport). A comprehensive overview of choline transport studies is provided. This review article examines landmark and current choline transport studies, molecular mapping, and molecular identification of these carriers. Information regarding the choline-binding site is presented by reviewing choline structural analog (hemicholinium-3 and 15, and other nitrogen/methyl-hydroxyl compounds) inhibition studies. Choline transport in Alzheimer's disease, brain ischemic events, and aging is also discussed. Emphasis throughout the article is placed on targeting the choline transporter in disease and use of this carrier as a drug delivery vector.
ChemInform Abstract: THE STRUCTURE OF SOME ANTIBIOTICS FROM THE SPONGE IRCINIA STROBILINA (1975)

Abstract Aus obiger Spezies werden die beiden antibiotisch wirksamen Furyl‐lactone (Ia) und (IIIa) isoliert und ihre Strukturen aufgeklärt.
Closed-form capacity expressions for SIMO channels with correlated fading (2005)

The closed-form capacity expressions for single- input multiple-output (SIMO) channels are investigated in frequency-flat correlated Rayleigh and Rician fading environ- ments. Exact closed-form expressions for the ergodic capacity and the complementary cumulative distribution function (CCDF) of the channel capacity (outage capacity) are derived for correlated Rayleigh channels. For correlated Rician channels, the exact closed-form capacity expressions are hard to derive due to its complicated distribution. Rather than using brute force, we tackle this issue by adopting some statistical approximations and obtain simple and accurate closed-form expressions based on the results of Rayleigh channels. The accuracy of these theoretical results is verified through computer simulations. Moreover, these closed- form expressions have very low computation complexity which makes them very useful for practical computations.
ChemInform Abstract: A New Hypoxia Inducible Factor‐2 Inhibitory Pyrrolinone Alkaloid from Roots and Stems of Piper sarmentosum. (2012)

Abstract A new trimethoxycinnamoyl‐2‐pyrrolidinone alkaloid, named langkamide (I), is isolated along with two known trimethoxycinnamoyl derivatives from roots and stems of the pepper shrub Piper sarmentosum.
Optimal trajectories for a liquid piston compressor/expander in a Compressed Air Energy Storage system with consideration of heat transfer and friction (2012)

For a Compressed Air Energy Storage (CAES) approach to be viable, the air compressor/expander must be sufficiently powerful and efficient. Since efficiency is governed by heat transfer, there is a generally a tradeoff between efficiency and compression/expansion time (or power). In this paper, we determine Pareto optimal compression/expansion profiles for a liquid piston air compressor/expander that maximizes efficiency (power) for a given power (efficiency). Compared to previous works, a numerical optimization approach is proposed that allows for more general heat transfer model, the consideration of the viscous friction, and system limitations in the optimization. The resulting optimal profiles are compared to other trajectories. At compression ratio of 10, the optimal profile results in 10%-40% increase in power density relative to other methods. Optimal geometries that trades off friction and heat transfer improvement can also be determined using this method.
The kinetics of sulfation of calcium oxide. [Quarterly] project status report, February 27, 1989--May 31, 1989 (1989)

Studies of the sulfation rate behavior show an initial fast rate followed by a rate decrease. It is generally agreed that product layer diffusion limitations are the explanation for this behavior. Many investigators tried to model this observed rate change, more or less successfully. No agreement has been reached, however, as to the value of the produce layer diffusivity. Hence, in this work we want to investigate the mechanism of this process. In addition to understanding the initial kinetics, two questions will be focused on. First, we should understand what is diffusing. It appears that the driving force for this diffusion phenomenon is not first order with the SO{sub 2} concentration in the gas. This would indicate that some other, intermediary step is occurring. The second question concerns the composition of the product layer. Different conditions at the start of the reaction were observed to produce different diffusion rates at a later stage. The microscopic appearance of the product layer also appeared to be different.
Generation of Factor VIII Coagulant Activity by Isolated, Perfused Neonatal Pig Livers and Adult Rat Livers (1979)

Isolated, normal, neonatal pig livers released VIII:C into perfusates of porcine von Willebrand blood lacking VIIIR:AG and VIII:RWF. Neonatal von Willebrand livers released VIII:C only when partially purified VIIIR:AG was added to the von Willbrand blood. Adult rat livers, perfused with frozen-thawed erythrocytes suspended in Tyrode's solution containing 6% bovine serum albumin and hence no VIIIR:AG released VIII:C only when serum, adsorbed serum or cryoprecipitate from rat plasma was added to the perfusate. Cycloheximide blocked the release of VIII:C from rat liver.
Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue (2019)

A vital role of adrenoceptors in metabolism and energy balance has been well documented in the heart, skeletal muscle, and adipose tissue. It has been only recently demonstrated, however, that activation of the mechanistic target of rapamycin (mTOR) makes a significant contribution to various metabolic and physiological responses to adrenoceptor agonists. mTOR exists as two distinct complexes named mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) and has been shown to play a critical role in protein synthesis, cell proliferation, hypertrophy, mitochondrial function, and glucose uptake. This review will describe the physiological significance of mTORC1 and 2 as a novel paradigm of adrenoceptor signalling in the heart, skeletal muscle, and adipose tissue. Understanding the detailed signalling cascades of adrenoceptors and how they regulate physiological responses is important for identifying new therapeutic targets and identifying novel therapeutic interventions. LINKED ARTICLES: This article is part of a themed section on Adrenoceptors-New Roles for Old Players. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.14/issuetoc.
Cytoplasmic polyadenylation of Toll mRNA is required for dorsal-ventral patterning in Drosophila embryogenesis (1998)

Toll encodes a receptor that is critical for dorsal-ventral patterning in the early Drosophila embryo. Previous data have suggested that the accumulation of Toll protein in the embryo temporally correlates with elongation of the poly (A) tail of the message. Here, we demonstrate that Toll mRNA is translationally activated by regulated cytoplasmic polyadenylation. We also identify a 192 nucleotide regulatory element in the Toll 3' UTR that is necessary for robust translational activation of Toll mRNA and also regulates polyadenylation. UV crosslinking analyses suggest that two proteins bind specifically to the 192 nucleotide element. One or both of these proteins may be factors that are required for translational regulation or cytoplasmic polyadenylation. These studies demonstrate that regulated polyadenylation plays a critical role in the Drosophila dorsal-ventral patterning system.
Diamine oxidase knockout mice are not hypersensitive to orally or subcutaneously administered histamine (2022)

Inactivation of exogenous histamine is not driven by enzymatic degradation and kidney filtration. Treatment with recombinant human DAO strongly reduced histamine-induced core body temperature loss, histamine concentrations and prevented the development of severe clinical symptoms.
Data from CD200 Checkpoint Reversal: A Novel Approach to Immunotherapy (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Advances in immunotherapy have revolutionized care for some patients with cancer. However, current checkpoint inhibitors are associated with significant toxicity and yield poor responses for patients with central nervous system tumors, calling into question whether cancer immunotherapy can be applied to glioblastoma multiforme. We determined that targeting the CD200 activation receptors (CD200AR) of the CD200 checkpoint with a peptide inhibitor (CD200AR-L) overcomes tumor-induced immunosuppression. We have shown the clinical efficacy of the CD200AR-L in a trial in companion dogs with spontaneous high-grade glioma. Addition of the peptide to autologous tumor lysate vaccines significantly increased the median overall survival to 12.7 months relative to tumor lysate vaccines alone, 6.36 months.&lt;/p&gt;Experimental Design:&lt;p&gt;This study was developed to elucidate the mechanism of the CD200ARs and develop a humanized peptide inhibitor. We developed macrophage cell lines with each of four CD200ARs knocked out to determine their binding specificity and functional response. Using proteomics, we developed humanized CD200AR-L to explore their effects on cytokine/chemokine response, dendritic cell maturation and CMV pp65 antigen response in human CD14&lt;sup&gt;+&lt;/sup&gt; cells. GMP-grade peptide was further validated for activity.&lt;/p&gt;Results:&lt;p&gt;We demonstrated that the CD200AR-L specifically targets a CD200AR complex. Moreover, we developed and validated a humanized CD200AR-L for inducing chemokine response, stimulating immature dendritic cell differentiation and significantly enhanced an antigen-specific response, and determined that the use of the CD200AR-L downregulated the expression of CD200 inhibitory and PD-1 receptors.&lt;/p&gt;Conclusions:&lt;p&gt;These results support consideration of a CD200AR-L as a novel platform for immunotherapy against multiple cancers including glioblastoma multiforme.&lt;/p&gt;&lt;/div&gt;