gebhart/patrepeval huggingface dataset:
Hepatic n-3 Polyunsaturated Fatty Acid Depletion Promotes Steatosis and Insulin Resistance in Mice: Genomic Analysis of Cellular Targets (2011)

Patients with non-alcoholic fatty liver disease are characterised by a decreased n-3/n-6 polyunsaturated fatty acid (PUFA) ratio in hepatic phospholipids. The metabolic consequences of n-3 PUFA depletion in the liver are poorly understood. We have reproduced a drastic drop in n-3 PUFA among hepatic phospholipids by feeding C57Bl/6J mice for 3 months with an n-3 PUFA depleted diet (DEF) versus a control diet (CT), which only differed in the PUFA content. DEF mice exhibited hepatic insulin resistance (assessed by euglycemic-hyperinsulinemic clamp) and steatosis that was associated with a decrease in fatty acid oxidation and occurred despite a higher capacity for triglyceride secretion. Microarray and qPCR analysis of the liver tissue revealed higher expression of all the enzymes involved in lipogenesis in DEF mice compared to CT mice, as well as increased expression and activation of sterol regulatory element binding protein-1c (SREBP-1c). Our data suggest that the activation of the liver X receptor pathway is involved in the overexpression of SREBP-1c, and this phenomenon cannot be attributed to insulin or to endoplasmic reticulum stress responses. In conclusion, n-3 PUFA depletion in liver phospholipids leads to activation of SREBP-1c and lipogenesis, which contributes to hepatic steatosis.
Forced and constrained consensus among cooperating agents (2005)

In this paper we consider the coordination of multiple agents via nearest-neighbor negotiations over a consensus variable. Existing results for single consensus variables are extended to include the cases of forced consensus, when one of the negotiating agents is driven by a setpoint, and of multiple consensus variables separated by hard constraints.
Orthogonal Matching Pursuit for Sparse Quantile Regression (2014)

We consider new formulations and methods for sparse quantile regression in the high-dimensional setting. Quantile regression plays an important role in many data mining applications, including outlier-robust exploratory analysis in gene selection. In addition, the sparsity consideration in quantile regression enables the exploration of the entire conditional distribution of the response variable given the predictors and therefore yields a more comprehensive view of the important predictors. We propose a generalized Orthogonal Matching Pursuit algorithm for variable selection, taking the misfit loss to be either the traditional quantile loss or a smooth version we call quantile Huber, and compare the resulting greedy approaches with convex sparsity-regularized formulations. We apply a recently proposed interior point methodology to efficiently solve all formulations, provide theoretical guarantees of consistent estimation, and demonstrate the performance of our approach using empirical studies of simulated and genomic datasets.
雷黙 處英의 생애와 불교사적 위상 (2018)

뇌묵 처영은 조선 중기를 대표하는 의승장이자 고승으로서 너무도 뚜렷한 위상을 지니고 있다. 하지만, 안타깝게도 우리는 그의 생몰연도에 관한 정보조차 갖고 있지 못하다. 처영과 관계된 기존 학계의 연구성과 역시 초라하다는 표현이 어울릴 정도이다. 이 논문은 이러한 문제점을 인식하면서 처영의 생애와 그가 지니고 있는 불교 사적 위상을 나름대로 살펴보고자 하는...
Sinogram restoration in computed tomography with an edge‐preserving penalty (2015)

Sinogram restoration with the Huber penalty is able to provide better resolution-noise performance than restoration with a quadratic penalty. Additionally, sinogram restoration with the Huber penalty is feasible for helical cone-beam CT and can be applied to clinical data.
Electromagnetically induced transparency inV-,Λ-, and cascade-type schemes beyond steady-state analysis (2005)

We analyze the electromagnetically induced transparency (EIT) in $V$-, $\ensuremath{\Lambda}$-, and cascade-type schemes in a time-dependent way via the Schr\"odinger-Maxwell formalism. We derive explicitly the analytical expressions of the space-time dependent probe field, the corresponding phase shift, absorption or amplification, group velocity, and group velocity dispersion for all the three schemes. These simple analytical expressions not only demonstrate explicitly the similarities and essential differences of the three schemes but also provide a convenient basis for investigating how the many-body effects in solids modify the magnitude, spectral shape, and space and time dependence of EIT and EIT-related quantum coherence phenomena.
Revêtements optiques à structure périodique II: Applications (1981)

Some characteristics of the reflection coefficient are considered in this paper. We study how to change the shape of the envelope reflection in the passband and consequently obtain an antireflection coating whatever the number of bases and, for a two-layer bases, the influence of the optical thickness difference on the properties of the deposit.
A Perspective on Frequency-Domain Beamformers in Room Acoustics (2011)

Signals captured by a set of microphones in a speech communication system are mixtures of desired signals and noise. In this paper, a different perspective on frequency-domain beamformers in room acoustics is provided. Specifically, the observed noise signals are divided into coherent and incoherent signal components while no assumptions are being made regarding the number of coherent noise sources and the noise sound field. From this perspective, performance measures are defined and existing beamformers are deduced. In addition, a new and general tradeoff beamformer is proposed that enables a compromise between noise reduction and speech distortion on the one hand, and coherent noise versus incoherent noise reductions on the other hand. The presented performance evaluation shows how existing beamformers and the tradeoff beamformer perform in different scenarios.
Consensus in networked multi-agent systems with adversaries (2011)

In the past decade, numerous consensus protocols for networked multi-agent systems have been proposed. Although some forms of robustness of these algorithms have been studied, reaching consensus securely in networked multi-agent systems, in spite of intrusions caused by malicious agents, or adversaries, has been largely underexplored. In this work, we consider a general model for adversaries in Euclidean space and introduce a consensus problem for networked multi-agent systems similar to the Byzantine consensus problem in distributed computing. We present the Adversarially Robust Consensus Protocol (ARC-P), which combines ideas from consensus algorithms that are resilient to Byzantine faults and from linear consensus protocols used for control and coordination of dynamic agents. We show that ARC-P solves the consensus problem in complete networks whenever there are more cooperative agents than adversaries. Finally, we illustrate the resilience of ARC-P to adversaries through simulations and compare ARC-P with a linear consensus protocol for networked multi-agent systems.
The Basophil-specific Protease mMCP-8 Provokes an Inflammatory Response in the Skin with Microvascular Hyperpermeability and Leukocyte Infiltration (2016)

Basophils have often been erroneously considered to be minor relatives or blood-circulating precursors of tissue-resident mast cells because of some phenotypic similarity between them, including basophilic secretory granules in the cytoplasm. However, recent studies revealed that the repertoire of serine proteases stored in secretory granules is distinct in them. Particularly, mouse mast cell protease 8 (mMCP-8) is specifically expressed by basophils but not mast cells despite its name. Therefore, mMCP-8 is commonly used as a basophil-specific marker, but its functional property remains uncertain. Here we prepared recombinant mMCP-8 and examined its activity in vitro and in vivo Purified recombinant mMCP-8 showed heat-sensitive proteolytic activity when α-tubulin was used as a substrate. One intradermal shot of mMCP-8, not heat-inactivated, induced cutaneous swelling with increased microvascular permeability in a cyclooxygenase-dependent manner. Moreover, repeated intradermal injection of mMCP-8 promoted skin infiltration of leukocytes, predominantly neutrophils and, to a lesser extent, monocytes and eosinophils, in conjunction with up-regulation of chemokine expression in the skin lesion. These results suggest that mMCP-8 is an important effector molecule in basophil-elicited inflammation, providing novel insights into how basophils exert a crucial and non-redundant role, distinct from that played by mast cells, in immune responses.
Multi-Modal Detection Fusion on a Mobile UGV for Wide-Area, Long-Range Surveillance (2019)

We introduce a self-contained, mobile surveillance system designed to remotely detect and track people in real time, at long ranges, and over a wide field of view in cluttered urban and natural settings. The system is integrated with an unmanned ground vehicle, which hosts an array of four IR and four high-resolution RGB cameras, navigational sensors, and onboard processing computers. High-confidence, low-false-alarm-rate person tracks are produced by fusing motion detections and single-frame CNN person detections between co-registered RGB and IR video streams. Processing speeds are increased by using semantic scene segmentation and a tiered inference scheme to focus processing on the most salient regions of the 43° × 7.8° composite field of view. The system autonomously produces alerts of human presence and movement within the field of view, which are disseminated over a radio network and remotely viewed on a tablet computer. We present an ablation study quantifying the benefits that multi-sensor, multi-detector fusion brings to the problem of detecting people in challenging outdoor environments with shadows, occlusions, clutter, and variable weather conditions.
Distribution of parathyroid hormone-2 receptor messenger ribonucleic acid in rat (1996)

The PTH2 receptor is a recently identified G protein-coupled receptor activated by PTH. Its amino acid sequence is most similar to the PTH/PTHrP receptor, but unlike the PTH/PTHrP receptor, it is activated by PTH and not by PTH-related peptide. We previously demonstrated using Northern blots that expression of PTH2 receptor messenger RNA was greatest within the brain and occurred at lower levels in pancreas, testis, and placenta. We have now obtained a complementary DNA encoding the rat PTH2 receptor and used it to study the distribution of the PTH2 receptor using in situ hybridization histochemistry. PTH2 receptor messenger RNA is abundantly expressed in arterial and cardiac endothelium and at lower levels in vascular smooth muscle. It is also abundant in the lung, both within bronchi and in the parenchyma, and is present within the exocrine pancreas. It is expressed by sperm in the head of the epididymis. A small number of cells associated with the vascular pole of renal glomeruli express the receptor. These data suggest that the PTH2 receptor may be responsible for PTH effects in a number of physiological systems.
논문 : 한국 수출입 함수추정에 관한 연구 (1998)

수출함수에 대한 실증분석은 경제정책적 측면에서 커다란 중요성을 갖고 있다. 수출의 가격 및 소득탄력성 등이 실증적으로 추정되면 그 결과는 많은 정책적 함의를 갖게 되기 때문이다. 그런데 지금까지 수출함수에 관한 많은 실증적 연구의 경우 환위험변수가 함수추정과정에 포함되지 않았다는 관점에서 모형설정의 적정성이 확보되지 못하였다. 이와 같은 모형설정의 불완전성 때문에 추정결과 얻게 되는 수출의 가격 및 소득탄력성 등은 실제의 수출행태를 대변하지 못하게 된다. 본 연구에서는 수출함수 추정을 위한 모형설정에서 환위험변수를 직접 포함시킴으로써 보다 진정한 수출행태를 반영하는 수출함수를 추정하고 있다. 그리고 실증 연구결과 환위험의 증가는 한국의 수출에 심각한 영향을 미치는 것으로 나타났다. 따라서 안정적인 수출을 유지하기 위해서는 외환시장의 안정이 매우 중요한 정책적 관심사가 되어야 한다.
Effect of a Single Quantum Rotational Excitation on State-to-State Dynamics of theO(D1)+H2→OH+HReaction (2002)

Crossed molecular beams scattering experiments on the O(1D)+H2 reaction have been carried out in order to study the effect of the reagent (H2) rotational excitation on the detailed dynamics of this benchmark insertion reation. Experimental results indicate that a single quantum rotational excitation of H2 has a significant impact on the product state distributions at the forward and backward scattering directions, while very little effect has been found in the sideway scattering direction. No clear patterns of this effect are found in the OH-product state distributions, indicating that the single quantum excitation on the dynamics is rather complicated.
ChemInform Abstract: Chemistry in Water (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Stabilizing Coacervate by Microfluidic Engulfment Induced by Controlled Interfacial Energy (2019)

Low interfacial energy, an intrinsic property of complex coacervate, enables the complex coacervate to easily encapsulate desired cargo substances, making it widely used in encapsulation applications. Despite this advantage, the low interfacial energy of the complex coacervate makes it unstable against mechanical mixing, and changes in pH and salt concentration. Hence, a chemical cross-linker is usually added to enhance the stability of the complex coacervate at the expense of sacrificing all intrinsic properties of the coacervate, including phase transition of the coacervate from liquid to solid. In this study, we observed an abrupt increase in the interfacial energy of the coacervate phase in mineral oil. By controlling the interfacial energy of the coacervate phase using a microfluidic device, we successfully created double engulfed PEG-diacrylate (PEGDA) coacervate microparticles, named DEPOT, in which the coacervate is engulfed in a cross-linked PEGDA shell. The engulfed coacervate remained as a liquid phase, retained its original low interfacial energy property to encapsulate the desired cargo substances, and infiltrated into the target site by a simple solvent exchange from oil to water.
Exploring cell membrane water exchange in aquaporin-4-deficient ischemic mouse brain using diffusion-weighted MRI (2021)

Multi-b-value multi-diffusion-time diffusion-weighted imaging may be useful for in vivo research and clinical diagnosis of aquaporin-4-related diseases.
Design of Folate-Linked Liposomal Doxorubicin to its Antitumor Effect in Mice (2008)

The results of this study will be beneficial for the design and preparation of ligand-targeting carriers for cancer treatment.
Tuneable stochastic domain-wall trajectories in a nanoscale magnetic Galton board (2021)

In this work , we describe the design, realisation and characterization of the magnetic version of the Galton Board, an archetypal statistical device originally designed to exemplify normal distributions. Although simple in its macroscopic form, achieving an equivalent nanoscale system poses many challenges related to the generation of sufficiently similar nanometric particles and the strong influence that nanoscale defects can have in the stochasticity of random processes. We demonstrate how the quasi-particle nature and the chaotic dynamics of magnetic domain-walls can be harnessed to create nanoscale stochastic devices [1]. Furthermore, we show how the direction of an externally applied magnetic field can be employed to controllably tune the probability distribution at the output of the devices, and how the removal of elements inside the array can be used to modify such distribution.
ChemInform Abstract: SYNTHESIS AND NMR STUDIES OF 2‐FLUOROTRIPHENYLPHOSPHINES AND THEIR DERIVATIVES (1983)

Abstract Aus den Chlorphosphinen (I) und dem aus (II) und Butyllithium hergestellten 2‐Fluorphenyllithium werden die Triarylphosphine (III) erhalten, die in die Derivate (IV) und (VI) übergeführt werden.
"O Navio Negreiro", de Castro Alves (2020)

A análise do poema “O Navio Negreiro”, de Castro Alves, leva-nos a perceber a posição tomada pelo autor contra a escravatura, revelando compaixão e uma visão emotiva da viagem dos escravos e do seu fado. The analysis of the poem “O Navio Negreiro”, by Castro Alves, makes us realize the author’s position against slavery, always expressing some compassion and an emotive vision of the slaves’ travel and of their fate.
Abstract 662: Generation and characterization of antibodies specific for IL1RAP antigen to target quiescent and proliferating AML leukemic stem cells (2014)

Abstract We have isolated and characterized blast cells and leukemic stem cells (LSCs) enriched from AML patients and identified cell surface targets selectively expressed on AML blast cells and LSCs and not their normal hematopoietic stem cell counterparts. A series of potent, specific, monoclonal antibodies (mAbs) have been generated against one of these AML LSC targets, IL1RAP. IL1RAP mAb clones were characterized for patient binding properties and also evaluated in in vitro cell based assays and in in vivo tumor xenograft models. These monoclonal antibodies demonstrated promising binding profiles in primary AML patients’ samples and robust anti-tumor activity in in vitro cell based assays and in vivo tumor xenograft models. Specifically, select clones have a high degree of specific binding to AML primary patient samples (&amp;gt;90%), and specifically kill primary patient AML cells in complement-dependent cytotoxicity assays. These IL1RAP clones are being evaluated for inhibition of clonogenic potential of AML patient samples in vitro in colony forming assays and against normal clonogenic hematopoietic bone marrow derived stem cells. Select IL1RAP mAb clones evaluated in orthotopic AML tumor xenograft models have shown potent inhibition of tumor engraftment as well as significant tumor growth inhibition effects ranging from 80-90%. Because a key driver of LSC resistance is their quiescence, we also evaluated the antitumor effect of IL1RAP mAbs on quiescent AML cells in vitro. In summary, the patient binding profiles and in vitro and in vivo efficacy against AML cells indicates that targeting IL1RAP is a promising therapeutic approach for the treatment of AML and has the potential for effective eradication of AML LSCs and long term remission in the clinic. Citation Format: Ping Jiang, Sharmili Roy, Jen Huang, Trang Dao-Pick, Jennifer Lu, Madhavi Mishra, Jeffrey Lin, Eric D. Hsi, Robert J. Tressler, Holger Karsunky. Generation and characterization of antibodies specific for IL1RAP antigen to target quiescent and proliferating AML leukemic stem cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 662. doi:10.1158/1538-7445.AM2014-662
IRQDebloat: Reducing Driver Attack Surface in Embedded Devices (2022)

Embedded and IoT devices often come with a wide range of hardware functionality, but any particular end user may only use some small subset of these features. However, even unused hardware features are accompanied by potentially buggy driver code, which increases the attack surface of the device. In this paper, we introduce IRQDebloat, a system for disabling unwanted hardware features through automated firmware rewriting. Building on the insight that external inputs to the system are typically delivered through interrupt requests (IRQs), IRQDebloat systematically explores the interrupt handling code in the target firmware, identifies the handler function for each peripheral, and finally rewrites target firmware to disable the handlers that correspond to undesired hardware features. In our experiments we demonstrate IRQDebloat’s effectiveness and generality by identifying IRQ handlers across four different operating systems (Linux, FreeBSD, VxWorks, and RiscOS) and seven different embedded platforms, and disabling selected peripherals on real-world hardware (a Raspberry Pi and a Valve Steam Link). On the Steam Link, we survey the attack surface and find that disabling selected peripherals could block up to 44 CVEs found in the Linux kernel over the past five years.
Detection of Two Chromatin Proteins Which Bind Specifically to the 5′-Flanking Region of the Rat Prolactin Gene (1985)

We employed a protein gel blotting procedure to search for nuclear proteins from rat pituitary cells that bind preferentially to the 5'-flanking region of the rat prolactin gene. By gel blots of chromatin proteins from GH3 rat pituitary tumor cells with a 32P-labeled prolactin genomic clone, we detected two major binding proteins with molecular weights of approximately 44,000 and 48,000, designated NP44 and NP48, respectively. Both NP44 and NP48 are minor chromatin proteins which are extracted at low salt concentrations (0.4 M NaCl) and exhibit a range of slightly acidic isoelectric variants. NP44 and NP48 were detected at similar levels in chromatin extracts of GH3 cells, the prolactin-negative GC cell variant of the GH3 cells, and normal rat pituitary tissue. Considerably lower levels of these two proteins were found in chromatin extracts from rat liver and rat C6 glial cells. NP44 and NP48 exhibit DNA sequence specificity, as evidenced by their strong binding to the upstream flanking region of the prolactin gene, but only very weak binding to plasmid DNA, rat prolactin or growth hormone cDNAs, or upstream flanking regions of two other rat genes. By analyzing subclones of a rat prolactin genomic clone, we established that NP44 and NP48 bind to at least two sites, which are located between 0.4 and 2.0 kilobases (region I) and between 2.0 and 4.8 kilobases (region II) upstream of the transcription initiation site. These findings are discussed in the context of a possible functional association between the strong binding of NP44 and NP48 to the prolactin 5'-flanking region and pituitary-specific expression of the prolactin gene.
Value added consultancy (2002)

The author argues that the value to a client of using a consultant in their team can only really be quantified at the conclusion of a project, when all things are considered and the final deliverable begins to show some tangible benefits.
Imaging the Drying of Surfaces by Infrared Thermography (2004)

Infrared (IR) thermography was used to monitor the drying of water from both smooth and rough surfaces. An analysis using the coefficient of variance (COV) of the temperature shows the point at which surface dryout begins. The dry spots that develop on a surface lead to temperature variations across the surface. The COV reflects these variations and is a sensitive measure of the early stages of dryout. The shape of the COV profile as the surface approaches dryness depends on the roughness of the surface. For rough surfaces such as wood, the COV climbs because differences in heat transfer to the heterogeneous wood surface are accentuated. Changes in the COV are much smaller for polymer films deposited on metal surfaces but are still dependent upon surface roughness.
An expeditious synthesis of methyl 5-(2-amino 4-arylthiazolyl) acetates using microwave irradiation (2006)

Al-Ameen College of Pharmacy, Hosur Road, Bangalore-560 027, India <em>E-mail </em>: Mattimarad@yahoo.com PES College of Pharmacy, Hanumanth Nagar, Bangalore-560 050, India <em>Manuscript received 4 July 2005, revised 19 September 2006, accepted 21 September 2006</em> 2,4,5-Trisubstituted thiazole derivatives can be prepared conveniently by condensation or methyl 3-bromo 3-aroyl propionates with thiourea and (un)substituted phenyl thiourea under microwave irradiation in good yields. The structures of the newly synthesized compounds are characterized by spectral data and elemental analysis.