gebhart/patrepeval huggingface dataset:
Regulation of Aspartate Family Amino Acid Biosynthesis in Brevibacterium flavum (1970)

Dihydrodipicolinate (DDP)* synthetase and DDP-reductase were partially purified about 30 and 15 folds, respectively, from sonic extracts of Breoibacterium flavum. In contrast with DDP-synthetase from Escherichia coli, the B. flavum enzyme was only slightly inhibited by α, ε-diaminopimelate, a precursor of lysine, but not by lysine itself. Single or simultaneous addition of any other amino acid (s) of aspartate family did not affect the activity significantly. Optimum pH for DDP-synthetase was 8.4 with Tris-HCI buffer. Kms for aspartic-β-semialdehyde and pyruvate at pH 7.5 were 2×10-4M and 1×10-4M, respectively. The formation of DDP-synthetase was not significantly repressed by lysine. DDP-reductase of B. flavum required NADH or NADPH as the cofactor. This enzyme was not inhibited by single or simultaneous addition of aspartate family amino acid (s). From the above results, the regulation mechanism of lysine biosynthesis in B. flavum was discussed.
China Tongxinluo Study for myocardial protection in patients with Acute Myocardial Infarction (CTS-AMI): Rationale and design of a randomized, double-blind, placebo-controlled, multicenter clinical trial (2020)

Acute ST-segment elevation myocardial infarction (STEMI) remains a serious life-threatening event. Despite coronary revascularization, patients might still suffer from poor outcomes caused by myocardial no-reflow and ischemic/reperfusion injury. Tongxinluo (TXL), a traditional Chinese medicine, has been preliminarily demonstrated to reduce myocardial no-reflow and ischemic/reperfusion injury. We further hypothesize that TXL treatment is also effective in reducing clinical end points for the patients with STEMI. METHODS AND RESULTS: The CTS-AMI trial is a prospective, randomized, double-blind, placebo-controlled, multicenter clinical study in China. An estimated 3,796 eligible patients with STEMI from about 120 centers are randomized 1:1 ratio to TXL or placebo groups. All enrolled patients are orally administrated a loading dose of 8 capsules of TXL or placebo together with dual antiplatelet agents on admission followed by 4 capsules 3 times a day until 12 months. The primary end point is 30-day major adverse cardiovascular and cerebrovascular events, a composite of cardiac death, myocardial reinfarction, emergency coronary revascularization, and stroke. Secondary end points include each component of the primary end point, 1-year major adverse cardiovascular and cerebrovascular events, and other efficacy and safety parameters. CONCLUSIONS: Results of CTS-AMI trial will determine the clinical efficacy and safety of traditional Chinese medicine TXL capsule in the treatment of STEMI patients in the reperfusion era.
Supplementary Figure 8 from Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC (2023)

&lt;p&gt;Supplementary Figure 8 - PDF file 215K, Photomicrographs of CO-1686 resistant NCI-H1975 cell (COR) clones and quantification of EGFR siRNA knockdown in COR clones&lt;/p&gt;
Best practice management of CINV in oncology patients: I. Physiology and treatment of CINV. Multiple neurotransmitters and receptors and the need for combination therapeutic approaches. (2010)

Chemotherapy-induced nausea and vomiting (CINV) involves multiple neurotransmitter and receptor systems; thus, its optimal treatment is likely to require a combination of therapies targeting multiple systems. Antiemetic regimens have evolved from use of dopamine antagonists alone to combination regimens such as a corticosteroid plus an antagonist of the serotonin (5-hydroxytryptamine) type 3 receptor or this combination with a neurokinin-1 receptor antagonist. The net result is that antiemetic efficacy has markedly increased with the addition of each new class of agent to treatment regimens. Further research is needed to determine optimal uses of available classes and agents for managing CINV, to elucidate the roles of additional neurotransmitters and receptors in both nausea and vomiting, and to develop new antiemetic agents.
Polyethylene glycol and solutions of polyethylene glycol as green reaction media (2005)

In this review, we examine the concept that aqueous biphasic reactive extraction (ABRE) can successfully integrate the solvent properties of polyethylene glycol (PEG) and its phase-transfer characteristics into a single efficient system which can additionally be manipulated to facilitate the separation of reactants and/or catalysts from products. We also suggest that the properties of these systems may recommend them as being relatively environmentally benign in comparison to the current use of organic solvents in extraction and in reactive extraction. In developing this concept, we review a number of the physical and chemical properties of PEG and aqueous solutions of PEG in the context of recent applications to chemical reaction engineering. Thus, we cover the interesting physical properties of PEG solutions in water, their unique solvent properties, and finally the metal cation coordination ability of PEG solutions. These properties are important in the application of low molecular weight liquid PEG as a solvent in chemical reactions; in the use of PEG as an alternative phase-transfer catalyst (PTC); and in the application of ABRE in the development of alternative pulping processes, catalytic chemistry, and enzymatic catalysis.
Inhibition by Tranilast of the Cytokine-Induced Expression of Chemokines and the Adhesion Molecule VCAM-1 in Human Corneal Fibroblasts (2010)

Inhibition by tranilast of the cytokine-induced expression of eotaxin-1, TARC, and VCAM-1 in human corneal fibroblasts suggests that this drug might prove effective for treatment of the corneal manifestations of ocular allergic inflammation by targeting corneal fibroblasts directly.
Upregulation of CD36, a Fatty Acid Translocase, Promotes Colorectal Cancer Metastasis by Increasing MMP28 and Decreasing E-Cadherin Expression (2022)

Altered fatty acid metabolism continues to be an attractive target for therapeutic intervention in cancer. We previously found that colorectal cancer (CRC) cells with a higher metastatic potential express a higher level of fatty acid translocase (CD36). However, the role of CD36 in CRC metastasis has not been studied. Here, we demonstrate that high expression of CD36 promotes invasion of CRC cells. Consistently, CD36 promoted lung metastasis in the tail vein model and GI metastasis in the cecum injection model. RNA-Seq analysis of CRC cells with altered expression of CD36 revealed an association between high expression of CD36 and upregulation of MMP28, a novel member of the metallopeptidase family of proteins. Using shRNA-mediated knockdown and overexpression of CD36, we confirmed that CD36 regulates MMP28 expression in CRC cells. siRNA-mediated knockdown of MMP28 decreases invasion of CRC cells, suggesting that MMP28 regulates the metastatic properties of cells downstream of CD36. Importantly, high expression of MMP28 leads to a significant decrease in active E-cadherin and an increase in the products of E-cadherin cleavage, CTF1 and CTF2. In summary, upregulation of CD36 expression promotes the metastatic properties of CRC via upregulation of MMP28 and an increase in E-cadherin cleavage, suggesting that targeting the CD36-MMP28 axis may be an effective therapeutic strategy for CRC metastasis.
Combined FE and Particle Swarm algorithm for optimization of high speed PM synchronous machine (2015)

Purpose – The purpose of this paper is to optimize the stator slot geometry of a high-speed electrical machine, which is used as an assist for a turbocharger. Meanwhile, the suitability of the Particle Swarm algorithm for such a problem is to be tested. Design/methodology/approach – The starting point of the optimization is an existing design, for which the Particle Swarm algorithm is applied in conjunction with the transient time-stepping 2D finite element method. Findings – It is found that regardless of its stochastic nature, the Particle Swarm work well for the optimization of electrical machines. The optimized design resulted in an increase of the slot area and increase of the iron loss, which was compensated by a dramatic decrease in the Joule losses. Research limitations/implications – The optimization was concentrated on the stator design whereas the rotor dimensioning was carried out withing the compressor and turbine design. Originality/value – A turbocharger with electric assist is designed optimized and manufactured. The Particle Swarm algorithm is shown to be very stable.
RNA diversity has profound effects on the translation of neuronal nitric oxide synthase (1999)

A comprehensive analysis of the structure of neuronal nitric oxide synthase (nNOS; EC 1.14.13.39) mRNA species revealed NOS1 to be the most structurally diverse human gene described to date in terms of promoter usage. Nine unique exon 1 variants are variously used for transcript initiation in diverse tissues, and each is expressed from a unique 5'-flanking region. The dependence on unique genomic regions to control transcription initiation in a cell-specific fashion burdens the transcripts with complex 5'-mRNA leader sequences. Elaborate splicing patterns that involve alternatively spliced leader exons and exon skipping have been superimposed on this diversity. Highly structured nNOS mRNA 5'-untranslated regions, which have profound effects on translation both in vitro and in cells, contain cis RNA elements that modulate translational efficiency in response to changes in cellular phenotype.
Design study of a solid-state heliogyro solar sail (1990)

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1990.
Enhanced Expression of Rab27A Gene by Breast Cancer Cells Promoting Invasiveness and the Metastasis Potential by Secretion of Insulin-Like Growth Factor-II (2008)

In addition to the functions of transporting melanosome in melanocytes and releasing contents of lytic granules in CTLs, Rab27A was recently shown to be involved in exocytosis of insulin and chromaffin granules in endocrine cells; it was also reported to be expressed in an exceptionally broad range of specialized secretory cells. As autocrine and paracrine cytokines are essential for invasion and metastasis in some solid tumors, blocking them may be an effective strategy to prevent tumor dissemination. In the present study, we show that Rab27A is associated with invasive and metastatic potentials of human breast cancer cells. The overexpression of Rab27A protein redistributed the cell cycle and increased the invasive and metastatic abilities in breast cancer cells both in vitro and in vivo. We also certified that Rab27A conferred the invasive and metastatic phenotypes on breast cancer cells by promoting the secretion of insulin-like growth factor-II (IGF-II), which regulates the expression of p16, vascular endothelial growth factor, matrix metalloproteinase-9, cathepsin D, cyclin D1, and urokinase-type plasminogen activator. These data provide functional evidence that Rab27A acts as a novel mediator of invasion and metastasis promotion in human breast cancer cells, at least in part, through regulating the secretion of IGF-II, suggesting that synergistic suppression of Rab27A and IGF-II activities holds a promise for preventing breast cancer invasion and metastasis.
Electrospray Mass Spectrometry Investigation into the Formation of CPO-27 (2019)

Electrospray ionization mass spectrometry (ESI-MS) has been utilized to investigate the self-assembly processes occurring during the formation of the microporous metal–organic framework CPO-27-M (M = Co, Ni). The mono- and dinuclear building units {M(Hxdhtp)} and {M2(Hxdhtp)}, where Hxdhtp is the organic linker HxC8O6 and fragments thereof, were identified as key species present in the reaction mixture during the product formation. Time-resolved powder X-ray diffraction analysis was used to follow the synthesis and confirmed that no other crystalline products occur in the reaction mixture prior to the crystallization of CPO-27-Ni. When equimolar reactions were performed at room temperature, compounds [(M(H2dhtp)(H2O)4·2H2O] (M = Co, Ni) crystallized instead of CPO-27 obtained at the higher temperature of the solvothermal procedure. It was confirmed that mono- and dinuclear species are key building blocks not only in the formation of CPO-27-M but also in the formation of the 1D chain structure (M(H2dhtp)(H2O)4) obtained from these room-temperature reactions.
Meander: visually exploring the structural variome using space-filling curves (2013)

The introduction of next generation sequencing methods in genome studies has made it possible to shift research from a gene-centric approach to a genome wide view. Although methods and tools to detect single nucleotide polymorphisms are becoming more mature, methods to identify and visualize structural variation (SV) are still in their infancy. Most genome browsers can only compare a given sequence to a reference genome; therefore, direct comparison of multiple individuals still remains a challenge. Therefore, the implementation of efficient approaches to explore and visualize SVs and directly compare two or more individuals is desirable. In this article, we present a visualization approach that uses space-filling Hilbert curves to explore SVs based on both read-depth and pair-end information. An interactive open-source Java application, called Meander, implements the proposed methodology, and its functionality is demonstrated using two cases. With Meander, users can explore variations at different levels of resolution and simultaneously compare up to four different individuals against a common reference. The application was developed using Java version 1.6 and Processing.org and can be run on any platform. It can be found at http://homes.esat.kuleuven.be/~bioiuser/meander.
Bilateral Parallel Force/Position Teleoperation Control (1999)

Abstract The application of parallel force/position control to teleoperation systems is considered in this paper. Higher priority is given to position control at the master side and to force control at the slave side of the teleoperation system. The stability and performance of the proposed controller is investigated by analyzing the three decoupled systems obtained from projecting the closed-loop system dynamics onto the slave task-space orthogonal directions. Experimental results demonstrate the excellent force and position tracking performance provided by the new controller.
Children included in randomised controlled trials of biologics in inflammatory bowel diseases do not represent the real‐world patient mix (2022)

Most children with IBD who initiate biologics would not have been eligible to be included in the corresponding regulatory RCTs. The outcomes of ineligible patients were worse than for eligible patients. Results from RCTs should be interpreted with caution when applied to clinical practice.
Rational use and interpretation of urine drug testing in chronic opioid therapy. (2007)

Urine drug testing (UDT) has become an essential feature of pain management, as physicians seek to verify adherence to prescribed opioid regimens and to detect the use of illicit or unauthorized licit drugs. Results of urine drug tests have important consequences in regard to therapeutic decisions and the trust between physician and patient. However, reliance on UDT to confirm adherence can be problematic if the results are not interpreted correctly, and evidence suggests that many physicians lack an adequate understanding of the complexities of UDT and the factors that can affect test results. These factors include metabolic conversion between drugs, genetic variations in drug metabolism, the sensitivity and specificity of the analytical method for a particular drug or metabolite, and the effects of intentional and unintentional interferants. In this review, we focus on the technical features and limitations of analytical methods used for detecting drugs or their metabolites in urine, the statistical constructs that are pertinent to ordering UDT and interpreting test results, and the application of these concepts to the clinical monitoring of patients maintained on chronic opioid therapy.
Additive regularizarion of topic models with fast text vectorizartion (2020)

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Toward Self-Supervised Feature Learning for Online Diagnosis of Multiple Faults in Electric Powertrains (2020)

This article proposes a novel online fault diagnosis scheme for industrial powertrains without using historical faulty or labeled training data. The proposed method combines a one-class support vector machine (SVM) based anomaly detection and supervised convolutional neural network (CNN) algorithms to online detect multiple faults and fault severities under variable speeds and loads. The one-class SVM algorithm is to derive a score for defining faults or health classes in the first stage, and the resulting health classes are used as the training data for the CNN-based classifier in the second stage. Within this framework, the self-supervised learning of the proposed CNN algorithm allows the online diagnosis scheme to learn features based on the latest data. The effectiveness of the scheme is validated via a comparison study using experimental data from an in-house test setup. Finally, the online implementation of the proposed scheme on the test setup is briefly introduced.
Natural clay binder based extrudates of mesoporous materials: improved materials for selective adsorption of natural and biogas components (2011)

The effects of natural clay binder based extrusion, on the selective adsorption properties of mesoporous materials were investigated in context of natural gas and biogas purification. Two mesoporous adsorbent materials, namely porous clay heterostructures (PCH) and MCM-41 were shaped into cylindrical extrudates, using a natural montmorillite clay binder. The effect of extrusion with clay binder was evaluated in three steps; (i) effects on structural properties, which were studied with low temperature nitrogen adsorption and XRD techniques; (ii) effect on adsorption capacity, which were evaluated with high pressure adsorption isotherms (up to 1000 kPa) for three main natural gas and biogas component gases which are CO2, C2H6, and CH4; (iii) effects of extrusion on selective adsorption properties of materials were investigated, for two commercially significant binary separations (CO2/CH4 and C2H6/CH4). Results show that, in general, extrusion caused an increase in mesoporosity of the final material; but in the case of MCM-41, an increase in microporosity has also been noticed. The order of maximum adsorption was found to be CO2 > C2H6 > CH4 with each material and the capacity of adsorption decreases to a different extent (dependent on gas) on extrusion. Variation in selectivity of these materials with pressure was studied and discussed. Both extrudates show satisfactorily high selectivity values than minimum requisite for an adsorbent to be used in separation process. However among all the four materials, the extrudate of MCM-41 was found most suitable, in terms of separation possibilities/applications.
Observations of atmospheric absorption lines from a stabilised balloon platform and measurements of stratospheric winds (1982)

A triple-etalon Fabry-Perot interferometer has been flown from a high altitude balloon platform as part of a development programme to implement a suggestion that stratospheric winds could be measured from a suitable spaceborne high resolution interferometer by observing the Doppler shifts of absorption lines in the visible light spectrum of sunlight backscattered (by Rayleigh or Mie scattering) from the Earth's atmosphere.
Salvage Chemotherapy for Refractory and Relapsed Posttransplant Lymphoproliferative Disorders (PTLD) After Treatment With Single-Agent Rituximab (2007)

CHOP salvage therapy achieved a favorable overall response rate of 70% in this setting, indicating that PTLD generally remains chemotherapy-sensitive after progression following first-line rituximab.
The Cholyl Glycine-1-<sup>14</sup>C Breath Test in Various Gastrointestinal Disorders (1979)

The cholyl glycine-1-14C breath test was evaluated in a variety of gastrointestinal disorders. 138 tests were performed in 106 patients. Methods of data expression were evaluated and the cumulative 8-hour value was used. In 27 control patients the upper limit of the normal was found to be 78. A good correlation was found between the peak values and the cumulative 8-hour values (r = 0.95, p less than 0.01). The reproducibility of the test was good (r = 0.985, p less than 0.05). Abnormal results were found in 12 out of 13 cases with resection of the ileum and 11 out of 14 cases with Crohn's disease of the distal small bowel. The test was normal in cases with diseases of the proximal small bowel (celiac, Whipple's and Chron's diseases). The test was also normal in patients with colitis. It was abnormal in some of the cases after cholecystectomy and in most cases with carcinoma of the pancreas. The breath test was useful in monitoring the results of treatment in bacterial overgrowth of the small bowel. False negative results were observed after antibiotic treatment. The method seems to be more sensitive than the Schilling test in diagnosing disease of the distal small bowel.
Chronic paracetamol treatment influences indices of reactive oxygen species accumulation in the aging Fischer 344 X Brown Norway rat aorta. (2012)

Previous reports have demonstrated that increased levels of reactive oxygen species (ROS) and alterations in cell signaling characterize aging in the Fischer 344 X Brown Norway (FBN) rat aorta. Other work has suggested that increases in ROS may be related to vascular wall thickening and the development of hypertension. Paracetamol (acetaminophen) is a potent antioxidant that has been found to diminish free radicals in ischemia-reperfusion studies. However, it remains unclear whether chronic paracetamol administration influences signaling or ROS accumulation in the aging aorta. FBN rats (27 months old; n=8) were subjected to 6 months of treatment with a therapeutic dose of paracetamol (30 mg/kg/day) and compared to age-matched untreated FBN rat controls (n=8). Compared to measurements in the aortae of 6-month old animals, tunica media thickness, tissue superoxide levels, and protein oxidation levels were 38 ± 7%, 92 ± 31%, and 7 ± 2% higher in the aortae of 33-month control animals (p ≤0.05). Chronic paracetamol treatment decreased tunica media thickness and the amount of oxidized protein by 13 ± 4% and 30 ± 1%, respectively (p ≤0.05). This finding of diminished aortic thickening was associated with increased phosphorylation (activation) of the mitogen activated protein kinases and diminished levels of the anti-apoptotic protein Bcl-2. Taken together, these data suggest that chronic paracetamol treatment may decrease the deleterious effects of aging in the FBN rat aorta.