gebhart/patrepeval huggingface dataset:
Efficacy, Tolerability, and Impact on Quality of Life of Long-Term Treatment with Manidipine or Amlodipine in Patients with Essential Hypertension (2001)

This double-blind, multicenter trial compared antihypertensive efficacy, tolerability, and impact on quality of life of manidipine and amlodipine in patients with mild-to-moderate essential hypertension. Patients were randomly assigned to 48 weeks of once-daily manidipine, 10-20 mg, or amlodipine, 5-10 mg. Patients who did not respond to treatment after 12 weeks were also given enalapril, 10-20 mg, for the study's duration. The main efficacy end point was equivalence in sitting systolic (SiSBP) and diastolic (SiDBP) blood pressure reduction between the two drugs after 8 weeks (per protocol analysis). An intention-to-treat (ITT) analysis was performed in all patients with at least one efficacy determination during treatment. Quality of life was assessed by the "Subjective Symptoms Assessment Profile" (SSA-P) and "General Well-being Schedule" (GWBS), after 12 weeks of treatment. SiSBP reduction after 8 weeks was equivalent for manidipine (15.2 mm Hg, n = 227) and amlodipine (17.0 mm Hg, n = 219). The corresponding figure for SiDBP was 11.3 mm Hg for manidipine and 12.3 mm Hg for amlodipine. In the larger ITT population SiDBP was similarly and significantly reduced by manidipine (from 102 +/- 5 to 88 +/- 9 mm Hg, n = 241) and amlodipine (from 101 +/- 5 to 87 +/- 8 mm Hg, n = 240). Similar results were observed for SiSBP and standing SBP and DBP. Neither drug changed sitting or standing heart rate compared with baseline. SSA-P scores improved with manidipine but not amlodipine. GWBS total and partial scores increased more with manidipine than with amlodipine. Safety profile favored manidipine, which was associated with significantly less ankle edema than was amlodipine. This study shows for the first time that long-term treatment with the long-acting calcium channel blocker manidipine is as effective as treatment with amlodipine, has a better tolerability profile, and induces greater improvement in quality of life than amlodipine.
FROM UNCERTAIN PROTEIN INTERACTION NETWORKS TO SIGNALING PATHWAYS THROUGH INTENSIVE COLOR CODING (2012)

Discovering signaling pathways in protein interaction networks is a key ingredient in understanding how proteins carry out cellular functions. These interactions however can be uncertain events that may or may not take place depending on many factors including the internal factors, such as the size and abundance of the proteins, or the external factors, such as mutations, disorders and drug intake. In this paper, we consider the problem of finding causal orderings of nodes in such protein interaction networks to discover signaling pathways. We adopt color coding technique to address this problem. Color coding method may fail with some probability. By allowing it to run for sufficient time, however, its confidence in the optimality of the result can converge close to 100%. Our key contribution in this paper is elimination of the key conservative assumptions made by the traditional color coding methods while computing its success probability. We do this by carefully establishing the relationship between node colors, network topology and success probability. As a result our method converges to any confidence value much faster than the traditional methods. Thus, it is scalable to larger protein interaction networks and longer signaling pathways than existing methods. We demonstrate, both theoretically and experimentally that our method outperforms existing methods.
Complete assignments of 1H and 13C NMR data for three new arylnaphthalene lignan from Justicia procumbens (2008)

Three new arylnaphthalene lignans, named neojusticin C (1), procumbenoside C (2) and procumbenoside D (3), have been isolated from the whole plant of Justicia procumbens, together with three known ones, justicidinoside B (4), justicidinoside C (5), and diphyllin-1-O-beta-D-apiofuranoside (6). The complete assignments of 1H and 13C NMR data for three new lignans were first obtained by means of 2D NMR techniques, including HSQC and HMBC.
Thyrotropin-Releasing Hormone Improves Neurologic Recovery After Spinal Trauma in Cats (1982)

Department of Neurology, Uniformed Services University of the Health Sciences, and Department of Medical Neurosciences, Walter Reed Army Institute of Research, Bethesda, Maryland and Washington, District of Columbia N. Engl. J. Med., 305: 1063-1067, October 29, 1981
Effect of Alcohol on Exercise‐Induced Changes in Serum Glucose and Serum Free Fatty Acids (1998)

The effect of alcohol on exercise-induced changes in serum glucose, serum free fatty acids, and serum insulin was studied in healthy male volunteers by performing an exhaustive ergometer exercise: (1) followed by alcohol intoxication (induced by 1.5 g of alcohol/kg of body weight); (2) during alcohol intoxication (induced by 0.8 g of alcohol/kg of body weight); and (3) during hangover (13 hr after a dose of 1.5 g of alcohol/kg of body weight). Acute alcohol intake immediately before exercise inhibited the exercise-induced increase in mean serum glucose concentration and caused a mild decrease in serum glucose levels during recovery from exercise. Exercise during hangover also resulted in decreased glucose levels during recovery from exercise. Alcohol administration immediately before or after exercise inhibited the postexercise increase in mean serum free fatty acids concentration. This was not seen during hangover, when blood alcohol concentration had already reached 0. In conclusion, alcohol interferes with the metabolism of carbohydrates during and after anaerobic exercise by decreasing the availability of circulating glucose. Furthermore, during recovery from exercise, alcohol decreases the supply of free fatty acids for the body.
An adapted novel flow cytometry methodology to delineate types of cell death in airway epithelial cells (2020)

Current methodologies to measure apoptotic and necrotic cell death using flow cytometry do not adequately differentiate between the two. Here, we describe a flow cytometry methodology adapted to airway epithelial cells (AEC) to sufficiently differentiate apoptotic and necrotic AEC. Specifically, cell lines and primary AEC (<i>n</i> = 12) were permeabilized or infected with rhinovirus 1b (RV1b) over 48 h. Cell death was then measured <i>via</i> annexin V/propidium iodide (A5/PI) or annexin V/TO-PRO-3 (A5/TP3) staining using a novel flow cytometry and gating methodology adapted to AEC. We show that A5/PI staining could not sufficiently differentiate between types of cell death following RV1b infection of primary AEC. However, A5/TP3 staining was able to distinguish six cell death populations (viable, necrotic, debris, A5<sup>+</sup> apoptotic, A5<sup>-</sup> apoptotic, apoptotic bodies) after permeabilization or infection with RV1b, with phenotypic differences were observed in apoptotic populations. Collectively, using a staining and gating strategy never adapted to AEC, A5/TP3 could accurately differentiate and quantify viable, necrotic, and apoptotic AEC following RV1b infection.
Effects of Pesticides on Filth Fly Predators (Coleoptera: Histeridae, Staphylinidae; Acarina: Macrochelidae, Uropodidae) in Caged Layer Poultry Manure (1990)

A field study on two caged layer poultry operations assessed whether selected pesticides would affect beneficial predators. Sampling was done three times during the 5-wk period before treatment, 3 d after each of two weekly treatments, and 5-6 times during the 10 wk after the second treatment. Cyromazine (0.1%) applied topically had no detrimental effect on any of the predator taxa. Dimethoate (0.5%) applied as a spot treatment to wet areas of the manure also did not reduce predator abundance. Permethrin (0.05%) applied as a direct treatment to the hens resulted in slight reductions in numbers of Histeridae and Staphylinidae in the manure. A resurgence of Fanniinae occurred at one site 3 wk after permethrin application. Treatment of whole houses with dimethoate (0.5%) resulted in short-term reductions (up to 3 wk) of predatory mites and reductions of Histeridae and Staphylinidae for 4-10 wk.
Estimating the Attributable Cost of Physician Burnout in the United States (2019)

Together with previous evidence that burnout can effectively be reduced with moderate levels of investment, these findings suggest substantial economic value for policy and organizational expenditures for burnout reduction programs for physicians.
In memory of Professor Teiji Tsuruta; great mentor in polymeric biomaterials (2017)

Professor Teiji Tsuruta, the emeritus professor of the University of Tokyo and the Founding Editor of the Journal of Biomaterials Science, Polymer Edition, passed away at age of 95 on 18 September ...
A morphological approach to the automatic detection of dark fringes applied to birefringence images (2016)

This work presents a novel approach to detect automatically the position of dark fringes in birefringence images. These positions are important for rheology (study of the flow of matter) applications, as they allow indirect measurements of physical properties of molten polymers without having to interact with the material. Our approach uses mathematical morphology techniques to find the patterns that characterize the fringes and detect the center position of each one of them. The results are compared with manual measurements, revealing the superior precision of our method. They have also been applied to the calculation of the stress field of some polymers with good results.
Fungal Pls1 tetraspanins as key factors of penetration into host plants: a role in re-establishing polarized growth in the appressorium? (2006)

The ability of plant pathogenic fungi to infect their host depends on successful penetration into plant tissues. This process often involves the differentiation of a specialized cell, the appressorium. Signalling pathways required for appressorium formation are conserved among fungi. However, the functions involved in appressorium maturation and penetration peg formation are still poorly understood. Recent studies have shown that Pls1 tetraspanins control an appressorial function required for penetration into host plants and are likely conserved among plant pathogenic fungi. Tetraspanins are small membrane proteins widely distributed among ascomycetes and basidiomycetes defining two distinct families; Pls1 tetraspanins are found in both ascomycetes and basidiomycetes and Tsp2 tetraspanins are specific to basidiomycetes. Both fungal tetraspanins families have similar secondary structures shared with animal tetraspanins. Pls1 tetraspanins are present as single genes in genomes of ascomycetes, allowing a unique opportunity to study their function in appressorium mediated penetration. Experimental evidence suggests that Pls1 tetraspanins are required for the formation of the penetration peg at the base of the appressorium, probably through re-establishing cell polarity.
Methanotrophic Chloroethene Transformation Capacities And 1,1-dichloroethene Transformation Product Toxicity (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMethanotrophic Chloroethene Transformation Capacities And 1,1-dichloroethene Transformation Product ToxicityMark E. Dolan and Perry L. McCartyCite this: Environ. Sci. Technol. 1995, 29, 11, 2741–2747Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/es00011a007https://doi.org/10.1021/es00011a007research-articleACS PublicationsRequest reuse permissionsArticle Views217Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Systematic elucidation of genetic mechanisms underlying cholesterol uptake (2023)

Genetic variation contributes greatly to LDL cholesterol (LDL-C) levels and coronary artery disease risk. By combining analysis of rare coding variants from the UK Biobank and genome-scale CRISPR-Cas9 knockout and activation screening, we have substantially improved the identification of genes whose disruption alters serum LDL-C levels. We identify 21 genes in which rare coding variants significantly alter LDL-C levels at least partially through altered LDL-C uptake. We use co-essentiality-based gene module analysis to show that dysfunction of the RAB10 vesicle transport pathway leads to hypercholesterolemia in humans and mice by impairing surface LDL receptor levels. Further, we demonstrate that loss of function of <i>OTX2</i> leads to robust reduction in serum LDL-C levels in mice and humans by increasing cellular LDL-C uptake. Altogether, we present an integrated approach that improves our understanding of genetic regulators of LDL-C levels and provides a roadmap for further efforts to dissect complex human disease genetics.
Scattering of SH guided wave by a circular cavity in a strip with the serrated boundary (2020)

The problem of dynamic stress concentration in anti-plane motion of a single circular cavity in a serrated boundary strip medium is studied. Firstly, the scattering of SH wave by a circular cavity defect in the straight line boundary strip medium is analysed based on guided wave theory. The scattering of waves around a circular cavity is expressed as series form by the employed wave function expansion method, and compatible scattering guided waves resulting from the reflection of waves off the boundaries of the elastic strip is constructed by repeated image superposition. The coefficients of the wave function expansion are determined based on the stress free condition of circular boundaries with pre-given incident guided waves. Then the center of the cavity is respectively moved to the upper and lower boundaries to form a depression, and the scattering of the SH-wave by the cavity in the strip with the depression is analyzed. The results of finite element method and analytical method are used to verify each other. A number of depressions are set up at the boundary to simulate a serrated boundary. Then the finite element method is used to analyze the SH wave scattering problem in the serrated boundary strip.
Characterization of URB Series Synthetic Cannabinoids by HRMS and UHPLC–MS/MS (2023)

A large number of synthetic cannabinoids are included in new psychoactive substances (NPS) and constitute an open research area in analytical pharmaceutical and toxicology when methods are needed to unambiguously identify these substances and their metabolites in biological fluids. A full molecular characterization of five synthetic molecules of the URB series that is able to interact with the endocannabinoid system was achieved with a high-resolution mass spectrometry (HRMS) in positive ion electrospray ionization and collisional experiments on the protonated parent ions, obtaining characteristic fragmentation patterns. Ultra-high-performance liquid chromatography coupled with a triple quadrupole (UHPLC-MS/MS) has also been used, which can help develop methods for screening and confirming synthetic cannabinoids in biological fluids.
Supplementary Tables S1-S12 from Gene-Level Germline Contributions to Clinical Risk of Recurrence Scores in Black and White Patients with Breast Cancer (2023)

&lt;p&gt;Supplementary Tables S1-S12&lt;/p&gt;
Reliable Code Disseminations Through Opportunistic Communication in Vehicular Wireless Networks (2018)

Large numbers of software-defined sensor devices have formed a basic infrastructure for data collection. One of the challenges is how to update the program codes of devices in a low-cost and reliable style. This paper figures that the vehicular wireless networks (VWNs), combined with a base station (BS) platform, can play a significant role in disseminating program codes in a smart city. A code dissemination algorithm that selects vehicles as disseminators is proposed to accomplish the coverage ratio of codes and benefits of vehicular disseminators in a reliable manner and to reduce the costs of the BS. The algorithm targets to make the disseminators to achieve more coverage regions of a code. The benefit distribution method, which targets the improvement of benefits in suburban regions and encourages vehicle owners, is redefined and differs from previous benefit distribution schemes. Through disseminating, the vehicles can obtain more benefits, and the costs of the BS can be reduced. We ultimately simulate the performances of the selection algorithms with GPS datasets to prove the progressiveness of the “Code Disseminations through Opportunistic Communication in Vehicular Wireless Networks”(CD-VWNs) scheme in terms of coverage and benefits. The benefit-ratio performance criterion can be improved by 21.078% over other models. The coverage-ratio performance criterion can result in an improvement of 31.94% over other selection schemes. The evaluation metric Zr performance criterion can result in an improvement of approximately 25.256%. With the CD-VWNs scheme, loss of codes can be decreased, and the dissemination system remains reliable and survivable.
Role of ABC transporters in cancer chemotherapy (2012)

Multidrug resistance (MDR) in cancer cells can significantly attenuate the response to chemotherapy and increase the likelihood of mortality. The major mechanism involved in conferring MDR is the overexpression of ATP-binding cassette (ABC) transporters, which can increase efflux of drugs from cancer cells, thereby decreasing intracellular drug concentration. Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs. This editorial highlights some major findings related to ABC transporters and current strategies to overcome MDR.
A microcomputer-based instrument for applications in platinum resistance thermometry (1983)

Platinum resistance thermometers are widely used in temperature measurements not only for calibration purposes but also in industrial applications. A new automatic instrument is described which can determine the actual value of the resistance of a platinum resistance thermometer in less than 0.52 s with a resolution of 8 PPM. The self-heating index can also be determined and the instrument is able to multiplex up to eight different platinum resistances. The temperature is calculated by using the interpolation formulae defined by the International Practical Temperature Scale of 1968 (IPTS-68).
Protein kinase associated with tubulin: affinity chromatography and properties (1976)

Rat brain tubulin purified by colchicine-agarose affinity chromatography contains protein kinase activity. The kinase activity can be separated completely from tubulin by chromatography on casein columns and is not subsequently retained by colchicine affinity columns. Protein kinase activity associated with purified tubulin does not correlate with the total content of protein kinase activity in brain homogenates, since microtubules isolated from 48 000g fetal brain supernatants contain twice as much protein kinase activity than adult microtubules, although the total protein kinase activity is twice as high in the 48 000g adult supernatant. The protein kinase of tubulin preparations, while corresponding to a different molecule than tubulin, is probably not simply the result of contamination. These observations are interpreted in terms of specific associations between protein kinase and tubulin complexes. The protein kinase-tubulin association may be an important determinant in the regulation of tubulin function. Fetal tubulin polymerizes twice as well as adult tubulin in the absence of glycerol at the same tubulin concentration. The preferred substrate for the protein kinase either in vivo or in vitro (pH 7.4, 37 degrees C) is a specific high-molecular-weight protein, distinct from tubulin, which copurifies with tubulin through different kinds of isolation procedures (i.e., colchicine affinity chromatography and ammonium sulfate precipitation followed by diethylaminoethyl-cellulose chromatography). The tubulin-associated protein kinase is completely dependent on cyclic adenosine monophosphate (Km=10(-7)M), as demonstrated by the complete suppression of activity upon addition of the protein kinase modulator, a well-known specific inhibitor of cAMP-dependent protein kinases
Out‐of‐plane shear‐axial failure in slender rectangular reinforced concrete walls (2022)

Abstract On 22 February 2011, one of the main structural walls of one of the tallest buildings in Christchurch, New Zealand (Grand Chancellor Hotel), had an extremely brittle and unusual failure that significantly damaged the building, severely compromising its structural stability. To this date, this peculiar failure mode has not yet been fully investigated and understood. Moreover, currently, it is not possible to identify and assess walls that are prone to this failure mode. Following recent findings based on experimental investigations, this failure mode was identified as out‐of‐plane shear‐axial failure. A Finite Element (FE) model was developed in DIANA to capture this failure mode, and through a numerical parametric study, the key parameters that contribute to the development of this failure mode in rectangular reinforced concrete (RC) walls were identified. Solid elements were used for the concrete material and embedded truss elements for the steel reinforcement. Bar buckling was not included in this investigation due to the limitation of DIANA in implementing the bar buckling and Menegotto‐Pinto models together, among which the latter was found to be more influential on the behaviour of RC walls investigated in this study. Based on the numerical and experimental studies conducted, an analytical method is proposed to: (1) identify rectangular walls prone to out‐of‐plane shear‐axial failure as a first‐level check for both design and assessment purposes; and (2) determine the out‐of‐plane drift capacity of rectangular walls prone to out‐of‐plane shear‐axial failure. Design recommendations are provided for rectangular walls prone to out‐of‐plane shear‐axial failure.
A slotted waveguide quasi-optical power amplifier (2003)

A power amplifier array based on a slotted waveguide power divider is presented. The advantages of this structure are its low profile and ease of fabrication. Efficient heat sinking of power devices is achieved. An X-band version of the power amplifier using eight MESFETs was designed and fabricated. An output power of 14 W was obtained.