gebhart/patrepeval huggingface dataset:
A relational database of protein structure (1989)

Conference Article| October 01 1989 A relational database of protein structure MICHAEL J. E. STERNBERG; MICHAEL J. E. STERNBERG 1Biomolecular Modelling Laboratory, Imperial Cancer Research Fund, P.O. Box 123, Lincoln's Inn Fields, London WC2A 3PX, U.K. Search for other works by this author on: This Site PubMed Google Scholar SUHAIL A. ISLAM SUHAIL A. ISLAM 1Biomolecular Modelling Laboratory, Imperial Cancer Research Fund, P.O. Box 123, Lincoln's Inn Fields, London WC2A 3PX, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1989) 17 (5): 845–847. https://doi.org/10.1042/bst0170845 Article history Received: April 18 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation MICHAEL J. E. STERNBERG, SUHAIL A. ISLAM; A relational database of protein structure. Biochem Soc Trans 1 October 1989; 17 (5): 845–847. doi: https://doi.org/10.1042/bst0170845 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: ISIS, integrated sequence/integrated structure data resource, SQL, structured query language, c.p.u., central processor unit This content is only available as a PDF. © 1989 Biochemical Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Regiospecific Synthesis of Mono-N-substituted Indolopyrrolocarbazoles (2005)

[reactions: see text] Two complementary and efficient strategies have been developed for the regiospecific synthesis of unsymmetrical indolopyrrolocarbazoles (IPCs) mono-N-substituted with a pentacycle. A halogen in position 2 of the intermediate bisindolylmaleimides 3a-e allows a selective Mitsunobu coupling by exploiting the increased acidity of the 2-chloro-substituted indole nitrogen. It also promotes an easier cyclization of bisindolylmaleimides 4a-e and 7b-e to IPCs. Alkylation of the 2-unsubstituted indole-3-carboxamides 2a,b and further processing to the corresponding IPCs gives access to the opposite regioisomers.
EDUCATION PRACTICE Sore Throat and a Red Hypopharynx: Is It Reflux? (2007)

g p Clinical Scenario A 54-year-old woman presents to your gastroenterology linic on a referral from the ear, nose, and throat (ENT) phyician to determine why the patient’s sore throat, cough, and aryngeal irritation are not responding to acid suppressive therpy. The patient reports chronic cough of 18 months in duraion and sore throat that has been persistent for the past year. er primary care physician referred her to an ENT physician, ho, after a laryngoscopic evaluation, informed the patient that e “sees signs of reflux” on her throat. Patient was started on nce daily proton pump inhibitor (PPI) therapy, which she akes before breakfast. However, she reported no improvement fter 6 weeks of therapy. Laryngoscopy was repeated, which ontinued to show irritation of the larynx. Patient was then eferred to you for diagnosis and treatment. Patient reports eing compliant with her medication and denies any heartburn r regurgitation at baseline. She is concerned that if the throat rritation is not treated, she might get throat cancer. How should you proceed with this case? How sensitive or pecific is the laryngoscopic evaluation for GERD? Has the atient been treated adequately, and does she benefit from ndoscopy (esophagogastroduodenoscopy), pH, or impedance onitoring? Would you perform the pH monitoring on or off herapy? If she remains symptomatic, is there a role for surgical undoplication?
Development and absolute frequency measurement of a pair of 778 nm two-photon rubidium standards (2005)

A pair of diode laser frequency standards stabilized to 778 nm two-photon rubidium transitions have been developed and characterized. Their sensitivity to vapour pressure, modulation depth and optical power have been investigated, along with their relative stability and day-to-day reproducibility. The Allan deviation of the standards locked to the 5 2S1/2(Fg = 3)–5 2D5/2(Fe = 5) transition of 85Rb is 9.3 × 10−13τ−1/2 for 1 s < τ < 100 s, reaching a floor of 1 × 10−13 at 100 s. The long-term repeatability of an individual system locked to this line is 1.2 kHz, corresponding to 3.1 parts in 1012. The system-to-system reproducibility is limited by cell impurities to 4.9 kHz and 4.5 kHz, respectively, for this line and the 5 2S1/2(Fg = 2)–5 2D5/2(Fe = 4) transition in 87Rb. The mean observed frequencies for these transitions, averaged for the two systems and corrected for light shift and second-order relativistic Doppler effect, are 385 285 142 375.1 (4.9) kHz and 385 284 566 374.2 (4.5) kHz, respectively.
SURFACE TREATMENT OF POLY (ETHYLENE TEREPHTHALATE) FABRIC WITH POLYETHYLENEIMINE (1997)

A branched polyethyleneimine (BPEI) was applied to poly(ethylene terephthalate)(PET) fabric to improve its surface moisture absorption so that the fabric becomes lessliable to retention of electrostatic charg. The durability of this treatment was assessed bywashing and followed by measurement of charge development on the fabric. The treatedsamples showed improved surface wetting compared to the untreated. The results areconsistent with attachment of the BPEI to the PET surface by a cross-linking mechanism.
Identification of Predictive Gene Markers for Multipotent Stromal Cell Proliferation (2016)

Multipotent stromal cells (MSCs) are known for their distinctive ability to differentiate into different cell lineages, such as adipocytes, chondrocytes, and osteocytes. They can be isolated from numerous tissue sources, including bone marrow, adipose tissue, skeletal muscle, and others. Because of their differentiation potential and secretion of growth factors, MSCs are believed to have an inherent quality of regeneration and immune suppression. Cellular expansion is necessary to obtain sufficient numbers for use; however, MSCs exhibit a reduced capacity for proliferation and differentiation after several rounds of passaging. In this study, gene markers of MSC proliferation were identified and evaluated for their ability to predict proliferative quality. Microarray data of human bone marrow-derived MSCs were correlated with two proliferation assays. A collection of 24 genes were observed to significantly correlate with both proliferation assays (|r| >0.70) for eight MSC lines at multiple passages. These 24 identified genes were then confirmed using an additional set of MSCs from eight new donors using reverse transcription quantitative polymerase chain reaction (RT-qPCR). The proliferative potential of the second set of MSCs was measured for each donor/passage for confluency fraction, fraction of EdU+ cells, and population doubling time. The second set of MSCs exhibited a greater proliferative potential at passage 4 in comparison to passage 8, which was distinguishable by 15 genes; however, only seven of the genes (BIRC5, CCNA2, CDC20, CDK1, PBK, PLK1, and SPC25) demonstrated significant correlation with MSC proliferation regardless of passage. Our analyses revealed that correlation between gene expression and proliferation was consistently reduced with the inclusion of non-MSC cell lines; therefore, this set of seven genes may be more strongly associated with MSC proliferative quality. Our results pave the way to determine the quality of an MSC population for a particular cellular therapy in lieu of an extended in vitro or in vivo assay.
Evaluation of Proposed Cab Glass Coating for FAA Control Towers (2013)

Abstract : AFRL assessed the effects of an after-market coating that could possibly be applied to FAA air traffic control tower (ATCT) windows intended to improve visibility out of the towers. Based on the results of the study, there is no reason to believe the coating would degrade vision through the glass for recently coated glass for the room temperature and humidity under which the samples were measured. However, the coating can degrade the view with haze at certain times of the day based on the angle of the sun. With the unexpected result that the coated side of the glazing increased observed haze effects, it is recommended that this phenomenon be investigated further. Additionally, the coating effects the distribution of water droplets from rain in such a way that one would expect improved visibility through the coated windows.
Efficient Heterogeneously Palladium-Catalysed Synthesis of Stilbenes and Bibenzyls (2008)

An alternative heterogeneously palladium catalysed procedure for the synthesis of functional stilbenes and bibenzyls is reported. Starting from aryl bromides and using simple commercially available Pd/C catalyst at a low catalytic rate (1 mol%), stilbenes are obtained with 30-100% GC-yields and bibenzyls are produced in a one-pot fashion with 27-100% GC-yields. The procedure showed, however, some limitations when applied to strongly deactivated aryl bromides that could be in some extent overcome by using corresponding iodo derivatives. Keywords: Stilbene synthesis, bibenzyl synthesis, one-pot synthesis, heterogeneous palladium catalyst
Gold-germanium laser jetting for high temperature (300&#x00B0;C) flip chip application (2014)

For downhole drilling applications, packages will have to endure extremely harsh conditions, which can easily reach a temperature of 300°C. At such high temperatures, the commonly adopted solder materials are lead-based as they are more readily available in paste and solder ball forms. While multiple studies have been performed on eutectic goldgermanium solder and its reliability at high temperature, little work has been done on the processing and assembly of the material into a flip chip package. This paper aims to study the feasibility of gold-germanium solder assembly through laser jetting process optimization. It is observed that Ge phase coarsening does not occur with laser jetting, compare to reflow process.
Tröger's Base‐Containing Aromatic Polymers with Unexpected Properties Endowed by the Insertion of Alkyne Spacers (2016)

Novel Tröger's base‐containing linear polymers are synthesized by the Pd‐catalyzed polycondensation of 2,8‐disubstituted Tröger's base monomers. Despite the nonplanarity of Tröger's base structure, there is a solubility problem for the resulting polymers. Careful selection of the comonomers and π‐spacers eventually produce high molecular weight polymers. All the polymers show high thermal stabilities with decomposition temperatures ( T d5% ) exceeding 300 °C. The optical and electrochemical properties of Tröger's base‐containing polymers are, to the best of our knowledge, investigated for the first time. They absorb UV light and emit a blue fluorescence in CH 2 Cl 2 solutions with the quantum yield reaching 0.72. The polymers with ethynylene spacers display a remarkable light‐green fluorescence in thin films as a result of excellent intermolecular interactions. Also, the redox activities depend on the chemical structures of the comonomers and π‐spacers. Remarkably, Tröger's base‐fluorene copolymer does not show any oxidation peaks, whereas the ethynylene‐linked copolymer exhibits a well‐defined oxidation at ≈1.1 V (vs Ag/Ag + ). The use of triphenylamine comonomers further enhances the redox activities. A facilitated oxidation occurs at the benzidine subunits, and a faster redox response is revealed by spectroelectrochemical measurements. image
La fabrique de la politique économique équatorienne. Le point de vue d’un acteur clé (2019)

MR. &amp; JFP. Il y a une dizaine d’années, vous aviez donné un entretien à la revue de la Régulation. Vous veniez d’être élu président de la République d’équateur et formuliez un programme intitulé « Plan National de Développement (2007-2025) » ; programme fidèle aux idées proposées dans la campagne par le parti Alianza Pais (Patrie fière et souveraine). Avec le recul de dix ans de mandat, vous avez volontairement quitté le pouvoir pour vivre avec votre famille en Belgique. Quel bilan faites-vou...
<title>Modeling liver motion and deformation during the respiratory cycle using intensity-based free-form registration of gated MR images</title> (2001)

In this paper, we demonstrate a technique for modeling liver motion during the respiratory cycle using intensity-based free-form deformation registration of gated MR images. We acquired 3D MR image sets (multislice 2D) of the abdomen of four volunteers at end-inhalation, end-exhalation, and eight time points in between using respiratory gating. We computed the deformation field between the images using intensity-based rigid and non-rigid registration algorithms. The non-rigid transformation is a free-form deformation with B-spline interpolation between uniformly-spaced control points. The transformations between inhalation and exhalation were visually inspected. Much of the liver motion is cranial-caudal translation, and thus the rigid transformation captures much of the motion. However, there is still substantial residual deformation of up to 2 cm. The free-form deformation produces a motion field that appears on visual inspection to be accurate. This is true for the liver surface, internal liver structures such as the vascular tree, and the external skin surface. We conclude that abdominal organ motion due to respiration can be satisfactorily modeled using an intensity-based non-rigid 4D image registration approach. This allows for an easier and potentially more accurate and patient-specific deformation field computation than physics-based models using assumed tissue properties and acting forces.
Thermoelastic properties and γ’-solvus temperatures of single-crystal Ni-base superalloys (2021)

Abstract The present work shows that thermal expansion experiments can be used to measure the γʼ-solvus temperatures of four Ni-base single-crystal superalloys (SX), one with Re and three Re-free variants. In the case of CMSX-4, experimental results are in good agreement with numerical thermodynamic results obtained using ThermoCalc. For three experimental Re-free alloys, the experimental and calculated results are close. Transmission electron microscopy shows that the chemical compositions of the γ- and the γʼ-phases can be reasonably well predicted. We also use resonant ultrasound spectroscopy (RUS) to show how elastic coefficients depend on chemical composition and temperature. The results are discussed in the light of previous results reported in the literature. Areas in need of further work are highlighted. Graphical abstract
Customized instruction-sets for embedded processors (1999)

It is generally believed that there will be little more variety in CPU architectures, and thus the design of Instruction-Set Architectures (ISAs) will have no role in the future of embedded CPU design. Nonetheless, it is argued in this paper that architectural variety will soon again become an important topic, with the major motivation being increased performance due to the customization of CPUs to their intended use. Five major barriers that could hinder customization are described, including the problems of existing binaries, toolchain development and maintenance costs, lost savings/higher chip cost due to the lower volumes of customized processors, added hardware development costs, and some factors related to the product development cycle for embedded products. Each is discussed, along with potential, sometimes surprising, solutions.
Colliding Interfaces in Old and New Diffuse-interface Approximations of\n Willmore-flow (2012)

This paper is concerned with diffuse-interface approximations of the Willmore\nflow. We first present numerical results of standard diffuse-interface models\nfor colliding one dimensional interfaces. In such a scenario evolutions towards\ninterfaces with corners can occur that do not necessarily describe the adequate\nsharp-interface dynamics.\n We therefore propose and investigate alternative diffuse-interface\napproximations that lead to a different and more regular behavior if interfaces\ncollide. These dynamics are derived from approximate energies that converge to\nthe $L^1$-lower-semicontinuous envelope of the Willmore energy, which is in\ngeneral not true for the more standard Willmore approximation.\n
Manipulation of a Single Charge in a Double Quantum Dot (2004)

We manipulate a single electron in a fully tunable double quantum dot using microwave excitation. Under resonant conditions, microwaves drive transitions between the (1,0) and (0,1) charge states of the double dot. Local quantum point contact charge detectors enable a direct measurement of the photon-induced change in occupancy of the charge states. From charge sensing measurements, we find T1 approximately 16 ns and a lower bound estimate for T*(2) of 400 ps for the charge two-level system.
Meteorological accuracy requirements for aerobraking orbital transfer vehicles (1984)

Accuracy requirements for the prediction of atmospheric density for a transfer mission from geosynchronous orbit to low earth orbit using an aerobraking orbital transfer vehicle are presented. Uniform density variations such as would occur seasonally and diurnally were considered as well as density 'pockets' similar to what may have been observed on some of the Space Shuttle Orbiter entry flights. Variations in the lift-to-drag ratio from 0.3 to 1.5 were evaluated, with the values of the ratio of the vehicle weight to the product of the aerodynamic lift coefficient and the aerodynamic reference area ranging from 20 to 100 lb/sq ft. The results of the study indicated no problems for the range of lift-to-drag ratio values considered for uniform density variations of at least + or - 50 percent. However, density 'pockets' created problems if variations of + or - 30 percent from nominal occurred over altitude ranges of 1,000 to 10,000 ft.
SignalStrength basedServiceDiscovery(53D) in Mobile Ad Hoc Networks (2005)

Service discovery isanimportant partofrealization towards ubiquitous computing withself-configurable mobile ad hocnetworks. However, itisfaced bythechallenge ofnetwork dynamics duetonodemobility. Inthispaper, we propose a signal strength basedservice discovery framework inmobile ad hocnetworks. Service discovery iscarried outselectively along reliable links bymonitoring thequalities ofwireless connections toneighbor nodes. We showbysimulation that, compared to non-selective distributed service discovery, ourapproach achieves higher service success ratio, less message overhead andshorter service discovery latency. I.INTRODUCTION Service discovery inMobile AdhocNETworks(MANET) isanimportant partofrealization towards service access anytime, anywhere. However, itposes greater challenges than intraditional distributed systems, since service failure more often results fromdisconnection duetohostmigration (1). Therefore, transient wireless mediumanddevice roaming require adedicated service discovery approach inMANET. Thebasic criteria forevaluating aservice discovery scheme
Traffic models in broadband networks (1997)

Traffic models are at the heart of any performance evaluation of telecommunications networks. An accurate estimation of network performance is critical for the success of broadband networks. Such networks need to guarantee an acceptable quality of service (QoS) level to the users. Therefore, traffic models need to be accurate and able to capture the statistical characteristics of the actual traffic. We survey and examine traffic models that are currently used in the literature. Traditional short-range and non-traditional long-range dependent traffic models are presented. The number of parameters needed, parameter estimation, analytical tractability, and ability of traffic models to capture marginal distribution and auto-correlation structure of the actual traffic are discussed.
A kind of new method to construct the strengthening buffer sequences and its characteristics (2011)

In this paper a new kind of the strengthening buffer operators is established to expand the research of buffer operators in grey systems, and it's feasibility and effectiveness are confirmed by an numerical example. Furthermore, the problem of contradictions between quantitative analysis and qualitative analysis in pretreatment for vibration data sequences is also resolved effectively. The paper is divided into five sections including introduction of the basic grey system theory and the motivation of this research, the establishment of the basic concepts, the construction of strengthening buffer sequences and their characteristics, numerical example demonstration and final conclusions.
Helminth infection promotes colonization resistance via type 2 immunity (2016)

Increasing incidence of inflammatory bowel diseases, such as Crohn's disease, in developed nations is associated with changes to the microbial environment, such as decreased prevalence of helminth colonization and alterations to the gut microbiota. We find that helminth infection protects mice deficient in the Crohn's disease susceptibility gene Nod2 from intestinal abnormalities by inhibiting colonization by an inflammatory Bacteroides species. Resistance to Bacteroides colonization was dependent on type 2 immunity, which promoted the establishment of a protective microbiota enriched in Clostridiales. Additionally, we show that individuals from helminth-endemic regions harbor a similar protective microbiota and that deworming treatment reduced levels of Clostridiales and increased Bacteroidales. These results support a model of the hygiene hypothesis in which certain individuals are genetically susceptible to the consequences of a changing microbial environment.
PET Molecular Imaging of Hypoxia in Ischemic Stroke: An Update (2015)

Hypoxia, a condition of insufficient oxygen availability to support metabolism, occurs when the vascular supply is interrupted, as in stroke. The identification of the hypoxic and viable tissue in stroke as compared with irreversible lesions (necrosis) has relevant implications for the treatment of ischemic stroke. Traditionally, imaging by positron emission tomography (PET), using 15O-based radiotracers, allowed the measurement of perfusion and oxygen extraction in stroke, providing important insights in its pathophysiology. However, these multitracer evaluations are of limited applicability in clinical settings. More recently, specific tracers have been developed, which accumulate with an inverse relationship to oxygen concentration and thus allow visualizing the hypoxic tissue non invasively. These belong to two main groups: nitroimidazoles, and among these the 18F-Fluoroimidazole (18F-FMISO) is the most widely used, and the copper-based tracers, represented mainly by Cu-ATSM. While these tracers have been at first developed and tested in order to image hypoxia in tumors, they have also shown promising results in stroke models and preliminary clinical studies in patients with cardiovascular disorders, allowing the detection of hypoxic tissue and the prediction of the extent of subsequent ischemia and clinical outcome. These tracers have therefore the potential to select an appropriate subgroup of patients who could benefit from a hypoxia-directed treatment and provide prognosis relevant imaging. The molecular imaging of hypoxia made important progress over the last decade and has a potential for integration into the diagnostic and therapeutic workup of patients with ischemic stroke.