gebhart/patrepeval huggingface dataset:
VEGF: Potential therapy for renal regeneration (2012)

Vascular endothelial growth factor (VEGF) plays a central role in angiogenesis. A number of studies have focused on its role in health and disease and discussed the possibility of VEGF as both a therapeutic tool and target based on its specific actions on vascular proliferation and cell survival. On one side, anti-VEGF therapies are at the fore-front of treatment of many solid tumors, but blockade of VEGF carries collateral effects such as hypertension and renal damage largely due to abnormalities in the microvasculature. On the other hand, recent clinical and experimental evidence has shown the feasibility of using VEGF administration to protect ischemic tissues such as the myocardium or the kidney via stimulation of microvascular proliferation and repair. In this commentary, we discuss the possibility and potential mechanisms of using intra-renal administration of VEGF to preserve the renal microcirculation and, consequently, decrease progressive renal injury in chronic renovascular disease. Targeted administration of VEGF may constitute a novel stand-alone or co-adjuvant intervention with the potential to become a part of a comprehensive plan to protect renal function.
SUMO ylation (2016)

Abstract Eukaryotic cells utilise the dynamic addition and removal of SUMO, a small ubiquitin‐like modifier (UBL), to modulate protein functions, interactions and localisation. Protein SUMOylation involves a cascade of dedicated enzymes that facilitate the covalent modification of specific lysine residues on target proteins with monomers or polymers of SUMO. The cellular homeostasis of SUMOylated proteins is also regulated by SUMO proteases and SUMO‐targeted ubiquitin ligase (STUbLs). SUMO proteases cleave SUMO from modified proteins. In contrast, STUbLs ubiquitinate proteins modified with SUMO chains. Recent data suggests that ubiquitination via STUbLs effects the turnover of SUMOylated proteins as well as the spatio‐temporal composition of complexes that contain SUMO‐modified proteins. Defects in the controlled addition, removal and turnover of SUMO‐modified proteins greatly affect cellular fitness and contribute to developmental defects, cancer and protein aggregation disorders. Key Concepts SUMO encodes a small ubiquitin‐like modifier that is covalently attached to lysines in target proteins. SUMOylation, the process of SUMO conjugation to a target protein, frequently occurs on a lysine situated in a SUMOylation consensus site. SUMO conjugates can be removed from target proteins by SUMO‐specific proteases. Vertebrates express three different SUMO isoforms: SUMO1, SUMO2 and SUMO3, encoded by three different genes. SUMOs can form polymers via internal SUMOylation sites in SUMO2 and SUMO3. Several proteins can bind non‐covalently to SUMOs via SUMO interaction motifs (SIMs). A finely balanced SUMOylation/de‐SUMOylation system is required for eukaryotic life. Cross‐talk between SUMOylation and ubiquitination plays a critical in the turnover of some SUMOylated proteins as well as the spatiotemporal composition of complexes that contain SUMO‐modified proteins.
Top antireflective coating process for immersion lithography (2005)

To accomplish minimizing feature size to sub 60nm, new light sources for photolithography are emerging, such as F2(157nm), and EUV(13nm). However, these new lithographic technologies have many problems to be solved for real device production. In case of F2 lithography, pellicle issue makes it difficult to use of F2 source in mass production. In case of EUV, light source and mask fabrication issues must be solved for real device application. For these reasons, instead of new light sources, extension of dry ArF lithography has been studied for sub 70nm device production by using Resolution Enhancement Technology (RET) such as using high NA tools, off axis illumination, and phase shift mask. Recently, a new technology called ArF immersion lithography is emerging as a next generation lithography. The first problem of this technology is contamination issues that come from the dissolution of contaminants from the photoresist to the immersion liquid. The second is optical problem that comes from the using hyper NA system. To solve these two problems, we have developed top antireflective coating (TARC) material. This TARC material can be coated on resist without damage to the resist property. In addition to, this TARC material is easily developable by conventional 2.38 wt% TMAH solution. The reflective index of this TARC is adjusted to 1.55, so it can act as an antireflective material. To this TARC material for immersion, quencher gradient resist process (QGRP) was applied also. As a result, we could improve resolution and process margin. However, some of resists showed defects that were generated by this TARC material and QGRP. To solve this defect problem, we introduced buffer function to the TARC material. Thanks to this buffer function, we could minimize defects of resist pattern in immersion lithography.
Secondary control of voltage & current unbalance in a multi-bus microgrid using cooperative adjustment of Q−droop gains (2017)

This paper describes a combined current and voltage unbalance compensation scheme for static power converters on a multi-bus microgrid utilizing cooperative regulation on a sparse ad-hoc communication network. The proposed control scheme is both robust to changing network conditions and corrects for sub-optimal gain settings at each distributed generation unit. The scheme is based on local voltage and current measurements by each distributed generation unit on the network, and utilizes a primary and secondary control hierarchy. The scheme is then simulated using Matlab SimPowerSystem to demonstrate operation of the compensation scheme and evaluate its performance.
Identification d'espèces bactériennes par spectrométrie de masse (2013)

Approches omiques globales : Profiling et Phenotypage Moleculaires. Cette journee portera sur l'utilisation des methodes omiques appliquees a differentes molecules (proteines et peptides, glycanes, lipides, metabolites), sur des modeles varies (homme, animal, vegetal, micro-organismes), pour repondre aux questions scientifiques soulevees dans le cadre de programmes Europeens, ANR, PHRC, ou Investissement d'Avenir. A travers ces illustrations, la journee presentera le savoir-faire et les competences de plusieurs plates-formes deployant ces approches en France.
Diamond Grinding Technology of Flexural Strength Test Pieces of Super hard, Brittle, Composite-ceramic Materials and Technological Equipment (2021)

At the present stage of the revolutionary development of technologies, scientists from the leading countries of the world are working intensively to create qualitatively new materials whose physical-mechanical, electrical, thermal or other properties far exceed the basic constructions, armament or other metals used. Such materials are surface, brittle, composite ceramic materials (based on oxide and carbide ceramics, state-of-the-art surface compositions, polycrystalline diamond + Si  SiC and etc.). A progressive process for diamond grinding test samples from composite ceramic materials to determine the bending strength is discussed. The proposed technological process is based on an original and effective method for polishing the flat surfaces of articles made of difficult-to-process and composite materials - low-temperature precision grinding (LPG). Based on the results of many years and multilateral studies in the field of diamond processing of various non-metallic, composite and ceramic materials, optimum conditions for diamond polishing of mentioned materials have been determined and recommended. Technological equipment and equipment for processing composite and ceramic materials are also disclosed.
PROOXIDANT AND ANTIOXIDANT ACTIVITIES OF ROSMARINIC ACID (2012)

ABSTRACT Rosmarinic acid is a fundamental compound of Rosmarinus officinalis. In this work, the intrinsic prooxidant (generation of H2O2 and free radicals by the action of peroxidase) and antioxidant (consumption of H2O2 and free radicals) properties of rosmarinic acid are characterized. In addition, its melanogenic prooxidant activity is characterized as it acts as a substrate of polyphenol oxidase to generate o-quinones, and its antimelanogenic and, so, antioxidant activity as it carries out the suicide inactivation of polyphenol oxidase. The balance between its pro- and antioxidant activities demonstrates that rosmarinic acid can be considered as a net antioxidant. PRACTICAL APPLICATIONS Antioxidants prevent oxidative damage by modulating the oxidative status of cells. The present results indicated that rosmarinic acid is an antioxidant and can act as scavenger of free radicals in biological systems, and could therefore provide health benefits to consumers. Moreover, rosmarinic acid can act as a suicide substrate of polyphenol oxidase and can inhibit the enzymatic browning of vegetables and fruits and melanogenesis in mammals.
Inhomogeneous driving in quantum annealers can result in orders-of-magnitude improvements in performance (2020)

Abstract Quantum annealers are special-purpose quantum computers that primarily target solving Ising optimization problems. Theoretical work has predicted that the probability of a quantum annealer ending in a ground state can be dramatically improved if the spin driving terms, which play a crucial role in the functioning of a quantum annealer, have different strengths for different spins; that is, they are inhomogeneous. In this paper we describe a time-shift-based protocol for inhomogeneous driving and demonstrate, using an experimental quantum annealer, the performance of our protocol on a range of hard Ising problems that have been well-studied in the literature. Compared to the homogeneous-driving case, we find that we are able to improve the probability of finding a ground state by up to 10 7 × for Weak–Strong–Cluster problem instances, and by up to 10 3 × for more general spin-glass problem instances. In addition to being of practical interest as a heuristic speedup method, inhomogeneous driving may also serve as a useful tool for investigations into the physics of experimental quantum annealers.
Vitamin D Receptor Genotype rs731236 (Taq1) and Breast Cancer Prognosis (2013)

Several studies have suggested that the anticancerogenous effects of vitamin D might be modulated by genetic variants in the vitamin D receptor (VDR) gene. The association of VDR polymorphisms with breast cancer-specific and all-cause mortality after a breast cancer diagnosis remains, however, largely unexplored. We assessed the association of genetic variants in VDR (rs731236, rs1989969, rs2228570, and 11568820) with breast cancer survival in a sample of 498 patients with breast cancer with a mean age at diagnosis of 61 years from Saarland, Germany, who were followed for up to 5 years with respect to total and breast cancer-specific mortality (56 and 48 events, respectively). Adjusted HRs with 95% confidence intervals (CI) were estimated by Cox regression models. We found that patients with breast cancer homozygous for the rare allele of rs731236 (15% of the women in our cohort) had a tendency toward an increased risk for breast cancer-specific mortality. The HR (95% CI) adjusted for age and breast cancer stage was 2.8 (1.1-7.2) for breast cancer-specific mortality and 2.1 (0.9-4.9) for total mortality. Additional adjustment for family history of breast cancer, radical mastectomy, and body mass index only marginally changed the estimates. No association was found for rs1989969, rs2228570, and rs11568820. Our analysis suggests that VDR polymorphism rs731236 might be associated with breast cancer-specific mortality, and if our findings are confirmed in future bigger studies rs731236 might deserve consideration as a prognostic factor in clinical care of patients with breast cancer.
Development of compact high precision two degree of freedom XY piezoelectric stepping positioner (2008)

In this article, a linear piezoelectric stepping positioner developed by Kang et al. [Rev. Sci. Instrum. 78, 075112 (2007)] is extended to have a two degree of freedom XY linear motion and it is experimentally evaluated. A resolution less than 10nm, a speed of over 0.5mm∕s, push forces of 17.9 and 19.5, and stiffnesses of 6.54 and 5.90N∕μm are attained while maintaining a compact size of 96×96×39mm3 and the required power consumption of 102.74W.
Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine (2015)

These results suggest that among children 5 to 17 months of age, the RTS,S vaccine has greater activity against malaria parasites with the matched circumsporozoite protein allele than against mismatched malaria. The overall vaccine efficacy in this age category will depend on the proportion of matched alleles in the local parasite population; in this trial, less than 10% of parasites had matched alleles. (Funded by the National Institutes of Health and others.).
Stress proteins on the yeast cell surface determine resistance to osmotin, a plant antifungal protein (1997)

Strains of the yeast Saccharomyces cerevisiae differ in their sensitivities to tobacco osmotin, an antifungal protein of the PR-5 family. However, cells sensitive to tobacco osmotin showed resistance to osmotin-like proteins purified from the plant Atriplex nummularia, indicating a strict specificity between the antifungal protein and its target cell. A member of a gene family encoding stress proteins induced by heat and nitrogen limitation, collectively called Pir proteins, was isolated among the genes that conveyed resistance to tobacco osmotin to a susceptible strain. We show that overexpression of Pir proteins increased resistance to osmotin, whereas simultaneous deletion of all PIR genes in a tolerant strain resulted in sensitivity. Pir proteins have been immunolocalized to the cell wall. The enzymatic digestion of the cell wall of sensitive and resistant cells rendered spheroplasts equally susceptible to the cytotoxic action of tobacco osmotin but not to other osmotin-like proteins, indicating that the cell membrane interacts specifically with osmotin and facilitates its action. Our results demonstrate that fungal cell wall proteins are determinants of resistance to antifungal PR-5 proteins.
Skin burns from electrosurgical current. (1983)

At 34 skin sites on anesthetized pigs, graded levels of average electrosurgical current density, J (A/cm2), at 500 kHz were delivered for specified times (t sec) to cause thermal injury. The severity of cutaneous response was determined by gross and microscopic study 56 hours later. The product J2t has been defined as the relative energy density factor, and is proportional to the delivered energy that determines skin heating. Nine of 10 sites that received low energy density factor exposure (J2t = 0.20-0.70 A2/cm4.sec-1) exhibited maximum skin temperatures of 38-47 degrees C beneath the electrodes, and subsequently has either no damage or as mild second-degree burn lying just beyond the electrode contact zone. At 9 of 11 sites exposed to a medium energy density factor (J2t = 0.70-1.60), the maximum skin temperatures below the electrodes were between 49 and 55 degrees C, with single or multiple rings of second-degree burns located just inside or beyond the rim of the electrode. At all 13 sites exposed to high energy density (J2t = 1.60-7.50), the maximum skin temperatures beneath the electrodes were 55-81 degrees C, and severe burns were produced with white to brownish, dry, firm, third-degree burns surrounded by peripheral rings of second-degree burns. No significant skin damage was produced with skin temperatures less than 45 degrees C (an energy density factor of 0.75). These data identify the temperature and energy density factor necessary to produce lesions on porcine skin.
A new lead-free 1D hybrid copper perovskite and its structural, thermal, vibrational, optical and magnetic characterization (2021)

A 1D perovskite, (C<sub>5</sub>H<sub>14</sub>N<sub>2</sub>) CuCl<sub>4</sub>, is stabilized as alternative lead-free material for more environmentally friendly solar cells. The absence of magnetic properties results from the cancelation of antiferromagnetic and ferromagnetic contributions.
ChemInform Abstract: CIRCUMAMBULATORY REARRANGEMENTS OF 1,7‐BRIDGED HOMOTROPYLIUM CATIONS (1979)

Abstract Behandlungen des Iodtetraens (I) und des Iodtrienons (III) mit Ag‐acetat bzw. DBN liefern die Azulen‐Derivate (II) und (IV).
On the Sensitivity and Spatial Resolution of Transient Pressure and Tracer Data for Heterogeneity Characterization (1997)

Summary This paper examines the sensitivities of interwell tracer and transient-pressure response to spatial distribution of permeability heterogeneity. On the basis of these sensitivities, we describe a formalism to quantify the resolution and spatial averaging associated with estimates of permeabilities derived through inversion of tracer and/or pressure data. The resolution is a measure of the effectiveness of the data in estimating local-scale (gridblock) permeabilities. The spatial averaging kernels quantify the inherent averaging associated with our estimates because of limited data or sampling. By examining the resolution and averaging kernels as a function of various data types, we can evaluate quantitatively the relative importance of tracer vs. pressure data for heterogeneity characterization and the improvement in estimates obtained by combining the data types. We illustrate the concepts by application to transient-pressure and tracer response from five-spot patterns and also to an experimental tracer response from a well-characterized slab of Antolini sandstone. Tracer data is found to yield much better resolution compared to transient-pressure response. Also, both transient-pressure and tracer data appear to resolve barriers to flow better rather than channels to flow.
Building-block synthesis of porphyrin light-harvesting arrays (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBuilding-block synthesis of porphyrin light-harvesting arraysSreedharan Prathapan, Thomas E. Johnson, and Jonathan S. LindseyCite this: J. Am. Chem. Soc. 1993, 115, 16, 7519–7520Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ja00069a068https://doi.org/10.1021/ja00069a068research-articleACS PublicationsRequest reuse permissionsArticle Views2054Altmetric-Citations244LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Step conformal solid electrolyte deposited by ALD on robust 3D silicon scaffold for on chip Li-ion microbattery (2016)

International audience
F-18 Fluorodeoxyglucose PET/CT as a Diagnostic Tool in Orbital Inflammatory Disorders (2021)

FDG-PET/CT enabled accurate reclassification of more than one-quarter of patients with SD, especially extraorbital lymphomas.
A Long Short-Term Memory-Based Model for Kinesthetic Data Reduction (2023)

This article proposes a novel mathematical model for teleoperation over communication networks. For teleoperation over a communication network, a high packet rate can result in inefficient data transmission and cross-traffic problems, leading to extra delay and jitter. This article proposes an long short-term memory (LSTM)-based mathematical model which focuses on kinesthetic data reduction without loss of transparency during the transmission process through joint training combined with haptic data and perceptual deadband. Since the LSTM network can deal with a time series of haptic data, we further test the system performance through practically collected data. We investigate the packet rate and perceptual transparency of the proposed mathematical model by comparing with the conventional deadband. Additionally, we compare the proposed mathematical model with the perceptual deadband-based codecs. Simulation results show that the proposed solution further reduces the packet rate when dealing with haptic data without noticeable distortion. Also, comparing with the current just noticeable difference perceptual threshold, the proposed mathematical model helps improve the practicality of the bilateral teleoperation system without losing transparency.
[Recovery of chronic hepatitis B- delta infection by zidovudine and recombinant interferon alpha combination therapy in a patient with Kaposi's sarcoma associated with HIV infection]. (1992)

A 39 years old homosexual male suffering from chronic type B hepatitis superinfected by HDV, and positive for anti-HIV1 was treated with zidovudine associated with high doses of recombinant interferon alpha for onset of an extensive cutaneous Kaposi sarcoma. Other than the long-lasting disappearance of Kaposi's lesions, this therapy was followed by complete recovery from hepatitis B and D. Serological and hepatic clearance of both viruses was marked by two successive cytolytic peaks separated by a 9 month interval. The patient's immunologic status has remained stable at 30 months. To our knowledge, such a success had never been reported in the literature and the clearance of both hepatitis B and D viruses in an AIDS patient stands in sharp contrast with the usual rapidly progressive evolution of those triple coinfections. This phenomenon illustrates the potential benefits of zidovudine in association with high dose of interferon alpha in HIV patients suffering from hepatitis D.
Real-time Interference Identification via Supervised Learning: Embedding\n Coexistence Awareness in IoT Devices (2018)

Energy sampling-based interference detection and identification (IDI) methods\ncollide with the limitations of commercial off-the-shelf (COTS) IoT hardware.\nMoreover, long sensing times, complexity and inability to track concurrent\ninterference strongly inhibit their applicability in most IoT deployments.\nMotivated by the increasing need for on-device IDI for wireless coexistence, we\ndevelop a lightweight and efficient method targeting interference\nidentification already at the level of single interference bursts. Our method\nexploits real-time extraction of envelope and model-aided spectral features,\nspecifically designed considering the physical properties of signals captured\nwith COTS hardware. We adopt manifold supervised-learning (SL) classifiers\nensuring suitable performance and complexity trade-off for IoT platforms with\ndifferent computational capabilities. The proposed IDI method is capable of\nreal-time identification of IEEE 802.11b/g/n, 802.15.4, 802.15.1 and Bluetooth\nLow Energy wireless standards, enabling isolation and extraction of\nstandard-specific traffic statistics even in the case of heavy concurrent\ninterference. We perform an experimental study in real environments with\nheterogeneous interference scenarios, showing 90%-97% burst identification\naccuracy. Meanwhile, the lightweight SL methods, running online on wireless\nsensor networks-COTS hardware, ensure sub-ms identification time and limited\nperformance gap from machine-learning approaches.\n