gebhart/patrepeval huggingface dataset:
Advanced Vehicle Miles Traveled Estimation Methods for Non-Federal Aid System Roadways Using GPS Vehicle Trajectory Data and Statistical Power Analysis (2019)

It is of interest to federal and state agencies to develop an advanced uniform method for estimation of vehicle miles traveled (VMT) on local roads which can be used as a guideline for agencies nationwide. The purpose of this study is to propose advanced innovative approaches for estimating VMT on local roads and analyze the feasibility of applying these methods. The paper presents a methodology and procedure for estimating local road VMT using GPS vehicle trajectory data and an all-street road network and expands these methodologies and results to determine the minimum required GPS sample size. The Federal Highway Administration and other transportation agencies may consider using these methodologies as a future guide to update VMT estimates with minimal additional cost requirements. The key finding of the research is that it is feasible to use new GPS vehicle trajectory data to estimate VMT on non-Federal Aid System roadways. The sample size of this data allows the application of this new method across the nation. The accuracy of this method was tested for the State of Maryland. Once such statewide GPS data is obtained by a given state, the methodology can be easily applied to that state as well.
Microfluidic Cardiac Cell Culture Model (μCCCM) (2010)

Physiological heart development and cardiac function rely on the response of cardiac cells to mechanical stress during hemodynamic loading and unloading. These stresses, especially if sustained, can induce changes in cell structure, contractile function, and gene expression. Current cell culture techniques commonly fail to adequately replicate physical loading observed in the native heart. Therefore, there is a need for physiologically relevant in vitro models that recreate mechanical loading conditions seen in both normal and pathological conditions. To fulfill this need, we have developed a microfluidic cardiac cell culture model (μCCCM) that for the first time allows in vitro hemodynamic stimulation of cardiomyocytes by directly coupling cell structure and function with fluid induced loading. Cells are cultured in a small (1 cm diameter) cell culture chamber on a thin flexible silicone membrane. Integrating the cell culture chamber with a pump, collapsible pulsatile valve and an adjustable resistance element (hemostatic valve) in series allow replication of various loading conditions experienced in the heart. This paper details the design, modeling, fabrication and characterization of fluid flow, pressure and stretch generated at various frequencies to mimic hemodynamic conditions associated with the normal and failing heart. Proof-of-concept studies demonstrate successful culture of an embryonic cardiomyoblast line (H9c2 cells) and establishment of an in vivo like phenotype within this system.
Strain Dependence of the Critical Temperature $T_{c}$ of Polycrystalline ${\rm Nb}_{3}{\rm Sn}$ Superconductors (2007)

The polycrystalline nature of Nb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn introduces crystal orientation as a possible variable in the strain dependence of the critical properties. It is shown that a dependence of strain sensitivity on crystal orientation implies a dependence on strain of the distribution of T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> , with implications for the functional dependence of strain sensitivity on the strain tensor. The distribution of T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> is found to have an influence on the characteristics of the resistive transition of T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> . Calculations of the resistive transition are done under alternative assumptions for the crystal orientation dependence of strain sensitivity. Available data on the strain dependence of the transition of T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> are contradictory and inconclusive. If strain sensitivity were found to be independent of grain orientation, that would imply a strain dependence on the entire deviatoric strain tensor, through the scalar invariants, including the tetragonal and shear parts. This would be a surprising conclusion given the emphasis on tetragonal strain in Nb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn .
P1819Impact of comorbidities on the predictive value of cardiac MIBG imaging in patients admitted for acute decompensated heart failure: a prospective comparative study (2018)

Background: Comorbidities are associated with poor clinical outcome in patients with chronic heart failure, and cardiac MIBG imaging also provides prognostic information in patients with heart failure. However, there is no information available on the impact of comorbidities on the prognostic value of cardiac MIBG imaging in patients admitted for acute decompensated heart failure (ADHF). Methods: We studied 354 consecutive ADHF patients with survival discharge. Comorbidity was measured with the Age-adjusted Charlson comorbidity index (ACCI) which is commonly used for the evaluation of the comorbid condition which is weighted and scored, with additional points added for age. Cardiac MIBG imaging were performed just before discharge and the cardiac MIBG heart-tomediastinum ratio (late HMR) were measured on the delayed image. The endpoint was cardiac event defined as a composite of cardiac death and unplanned hospitalization for worsening heart failure. Results: During a follow-up period of 2.11.4 years, 133 patients had cardiac event. At multivariate Cox analysis, ACCI (p=0.0003) and late HMR (p=0.0001) were significantly and independently associated with cardiac event. Patients with high ACCI (6: median value) had a significantly greater risk of cardiac event (47% vs 26%, p=0.0001,). In the subgroup of high ACCI6, patients with low late HMR (<1.55 determined by ROC analysis) had a significantly greater risk of cardiac event (68% vs 37% p<0.0001,). Furthermore, in the subgroup of low ACCI<6, patients with low late HMR (<1.48 determined by ROC analysis) also had a significantly greater risk of the cardiac event (54% vs 26%, p=0.0001, adjusted HR 3.62 [1.94-6.77]).
Secure attribute-based systems (2006)

Attributes define, classify, or annotate the datum to which they are assigned. However, traditional attribute architectures and cryptosystems are ill-equipped to provide security in the face of diverse access requirements and environments. In this paper, we introduce a novel secure information management architecture based on emerging attribute-based encryption (ABE) primitives. A policy system that meets the needs of complex policies is defined and illustrated. Based on the needs of those policies, we propose cryptographic optimizations that vastly improve enforcement efficiency. We further explore the use of such policies in two example applications: a HIPAA compliant distributed file system and a social network. A performance analysis of our ABE system and example applications demonstrates the ability to reduce cryptographic costs by as much as 98% over previously proposed constructions. Through this, we demonstrate that our attribute system is an efficient solution for securely managing information in large, loosely-coupled, distributed systems.
Invading basal cell carcinoma of the jaw: an under-evaluated complex entity. (2001)

Basal cell carcinoma (BCC) is a locally invasive neoplasm, rarely metastatic, yet capable of significant local destruction and disfigurement. Invasion into the bone is uncommon and only a few cases of invasion into facial bones, but never to the mandible or maxilla, have been described. We report three patients with BCC lesions invading their jaws, as a consequence of which either their mandible or maxilla had to be partially resected. This resulted in facial mutilation which required comprehensive multi-disciplinary therapy to restore function and esthetics. Such therapy requires a combination of modalities offered by both plastic and maxillofacial surgeons, as well as oral and dental rehabilitators.
Dual-doped thermographic phosphor particles as surrogates for green fluorescent protein-labeled cells in tests of cytometric neurocatheters (2010)

We investigated the laser-induced fluorescence of particles of a compound thermographic phosphor La2O2S:Eu(1%) and Gd2O2S:Eu(1%) to see if they can serve as a surrogate for cells transfected with the green fluorescent protein, in tests of neurocatheters used for intraparenchymal cell delivery. At an excitation wavelength of 337 nm and a concentration of ≈2×106 particles ml−1, the resulting slurries produced fluorescence intensities at 625 nm that were within a factor of 2 of those produced by similar number densities of relevant cells, thus suggesting the utility of this approach.
Bilateral lameness in horses a kinematic study (1995)

The kinematic pattern of mild bilateral lameness was studied by inducing a supporting limb lameness in both fore-limbs of 11 sound Dutch Warmblood horses. The kinematics of the horses were recorded while they trotted (3.5 m/s) on a treadmill. The locomotion analysis system CODA-3 was used to determine the temporal stride patterns, limb movements as well as head and trunk movement patterns. The transient lameness model, by which pressure-induced pain is evoked on the hoof sole, was used. Differences between left and right limbs as well as between the sound and the lame condition were tested using a paired t-test. Stride and stance duration did not change significantly (p < 0.05) during bilateral lameness compared to the pattern of sound horses. Diagonal advanced placement changed to an earlier placement of both forelimbs. Fetlock hyperextension decreased also in both forelimbs, while the pro- and retraction, hoof impact angle, maximal hoof height, and all hind limb variables remained unchanged. Vertical head and trunk movements tended to decrease, but these changes were not significant. It was concluded that fetlock hyperextension and diagonal advanced placement indicate locomotor disturbances, but that mild bilateral lameness may be difficult to distinguish from individual patterns in single assessments because of the lack of locomotor asymmetries. Evaluation of these variables at regular intervals may allow an early detection of bilateral lameness, which then could be confirmed by diagnostic local anaesthesia.
A case of active pulmonary tuberculosis with hypercalcemia (1987)

症例は腹膜炎を合併した活動性肺結核の63才,女性で,やせの改善のために施行したvitamin Dを含むIVHが契機となって高Ca血症が出現した.抗結核薬の投与により胸部異常影の消失,喀痰の結核菌培養陰性に伴い,再上昇していた血清Caの完全な正常化が認められたことから肺結核症に合併した高Ca血症と診断した.活動性肺結核にしばしば伴うvitamin DおよびCaの代謝異常がその基盤に存在したものと推測される.
Crystal structure of recombinant human T-cell cyclophilin A at 2.5 A resolution. (1991)

The structure of the unligated human T-cell recombinant cyclophilin has been determined at 3 A resolution by multipole isomorphous replacement methods and refined at 2.5 A resolution to an R factor of 0.209. The root-mean-square errors of the bond lengths and bond angles are 0.013 A and 2.8 degrees from ideal geometry, respectively. The overall structure is a beta-barrel, consisting of eight antiparallel beta-strands wrapping around the barrel surface and two alpha-helices sitting on the top and the bottom closing the barrel. Inside the barrel, seven aromatic and other hydrophobic residues form a compact hydrophobic core. A loop of Lys-118 to His-126 and four beta-strands (B3-B6) constitute a pocket we speculate to be the binding site of cyclosporin A.
Fundamental insight in soot oxidation over a Ag/Co3O4 catalyst by means of Environmental TEM (2013)

A novel Ag/Co3O4 catalyst for low-temperature soot oxidation has been studied by means of environmental TEM in order to get fundamental insight in the oxidation mechanism. Soot particles generated in diesel engines are responsible for respiratory diseases, lung cancer and affect the climate both locally and globally. Removal of these particles from the exhaust gas is normally carried out by filtration through a ceramic filter. A major disadvantage of this technique is the need for periodic regenerations involving temperature increases in order to oxidize the collected soot. In an effort to minimize the filter regeneration temperature – ideally down to the normal temperature of the exhaust gas - a new catalyst for soot oxidation consisting of Ag nanoparticles supported on Co3O4 has been synthesized using flame spray pyrolysis and characterized using electron microscopy and X-Ray diffraction. Catalytic tests of the novel Ag/Co3O4 system carried out in a flow reactor show high conversion efficiencies. The temperature dependence of the soot oxidation rate for this new system cannot be directly described in terms of the activity of the single Ag and Co3O4 components, but is strongly dependent on preparation method, degree of contact with the soot and temperature range. In order to fully understand the role of the single constituents and the influence of different operating conditions in the overall catalytic activity, flow reactor experiments have been coupled with in situ soot oxidation in an Environmental TEM (ETEM) at different temperatures and gas compositions.
Frequency-dependent polarization of light scattered near theNa D2resonance line (1982)

We report measurements of the degree of linear polarization of scattered light as a function of excitation frequency near the Doppler-broadened $\mathrm{Na} D2$ resonance line. For resonant excitation of the $D2$ line, the hyperfine interaction strongly depolarizes the emitted light due to precession of the electronic angular momentum $\stackrel{\ensuremath{\rightarrow}}{\mathrm{J}}$ prior to spontaneous emission. However, as the laser frequency is tuned away from resonance, the polarization degree sharply rises to the level predicted using a simple $J{M}_{J}$ basis, i.e., neglecting any coupling of the electronic angular momentum $\stackrel{\ensuremath{\rightarrow}}{\mathrm{J}}$ with the nuclear spin $\stackrel{\ensuremath{\rightarrow}}{\mathrm{I}}$. Roughly speaking, there is a transition from $F$ selection rules ($\stackrel{\ensuremath{\rightarrow}}{\mathrm{F}}=\stackrel{\ensuremath{\rightarrow}}{\mathrm{I}}+\stackrel{\ensuremath{\rightarrow}}{\mathrm{J}}$) for resonant excitation to $J$ selection rules for off-resonant excitation. We present a rigorous calculation of the polarization degree with the use of multipole moments of the density matrix which agrees quantitatively with our data and also predicts complicated interference structure when Doppler broadening is negligible. We show that this structure may shift peaks observed in precision laser-spectroscopy experiments. For Doppler-broadened transitions we discuss a simplified approach (based on an approximation to the Voigt profile) which treats separately the contributions of resonant and off-resonant scattering.
Lactate-avid regulatory T cells: metabolic plasticity controls immunosuppression in tumour microenvironment (2021)

Transcranial direct current stimulation (tDCS) is increasingly used as a form of noninvasive brain stimulation to treat psychiatric disorders; however, its mechanism of action remains unclear. Prolonged visual stimulation (PVS) can enhance evoked EEG potentials (visually evoked potentials, VEPs) and has been proposed as a tool to examine long-term potentiation (LTP) in humans. The objective of the current study was to induce and analyze VEP plasticity and examine whether tDCS could either modulate or mimic plasticity changes induced by PVS. Thirty-eight healthy participants received tDCS, PVS, either treatment combined or neither treatment, with stimulation sessions being separated by one week. One session consisted of a baseline VEP measurement, one stimulation block, and six test VEP measurements. For PVS, a checkerboard reversal pattern was presented, and for tDCS, a constant current of 1 mA was applied via each bioccipital anodal target electrode for 10 min (Fig. S1). Both stimulation types decreased amplitudes of C1 compared to no stimulation (F = 10.1; p = 0.002) and led to a significantly smaller increase (PVS) or even decrease (tDCS) in N1 compared to no stimulation (F = 4.7; p = 0.034). While all stimulation types increased P1 amplitudes, the linear mixed effects model did not detect a significant difference between active stimulation and no stimulation. Combined stimulation induced sustained plastic modulation of C1 and N1 but with a smaller effect size than what would be expected for an additive effect. The results demonstrate that tDCS can directly induce LTP-like plasticity in the human cortex and suggest a mechanism of action of tDCS relying on the restoration of dysregulated synaptic plasticity in psychiatric disorders such as depression and schizophrenia.
Ventricular contracture and compliance changes with global ischemia and reperfusion, and their effect on coronary resistance in the rat. (1977)

We measured ventricular contracture and compliance (passive distensibility) of the isolated rat heart during and after 30 minutes of complete global ischemia. The passive filling or distensibility curves of intra-left ventricular pressure vs. volume were linear between 0 and 30 mm Hg during the control, ischemic, and reperfusion periods. During ischemia the effective stiffness (distensibility slope) of the ventricle increased from the preischemic control of 0.229 0.027 to 0.514 0.083 mm Hg/pl (P < 0.005); with reperfusion, stiffness markedly increased to 1.743 0.442 mm Hg//tl (P < 0.001 vs. control). The changes in passive distensibility were parallel to changes in contracture which occurred when the ventricle was held in the isovolumic condition; during ischemia, contracture increased the preischemic diastolic pressure of -2 1 to 17 3 mm Hg (P < 0.001); in the early reperfusion period intense ventricular contracture occurred to a pressure of 75 6 mm Hg (P < 0.001 vs. preischemic control). After 30 minutes of reperfusion contracture pressure decreased to 34 7 mm Hg, (P < 0.001 vs. control). Contracture during reperfusion was associated with a parallel increase in the coronary vascular resistance; postischemic contracture may thus contribute to the no reflow phenomenon observed with attempted reperfusion of ischemic myocardium. The severity of contracture which occurred during ischemia and reperfusion was inversely related to the amount of ischemic tissue lactate accumulation and did not correlate with changes in tissue water content. Thus, global ischemia and reperfusion markedly decreased passive ventricular compliance; in the intact animal ventricular filling could be impaired by this process and diastolic pressure measurements would reflect the change in compliance as well as in ventricular contractile function.
ChemInform Abstract: SUBSTITUENTENEINFLUESSE AUF DIE ELEKTRONENSTOSS‐INDUZIERTE FRAGMENTIERUNG VON PHENOXASTANNINEN (1971)

Abstract Für die Elektronenstoß‐induzierte Fragmentierung der fünf Phenoxastannine (I) und der verwandten Verbindungen (II) und (III) wird die Ablösung eines an Zinn gebundenen Radikals als einleitender Schritt ermittelt.
π-Cationic cyclisations of N-acyliminium ions from imide-ester functionality: Use of olefin as nucleophile (1999)

International audience
Removal of hexavalent chromium in carbonic acid solution by oxidizing slag discharged from steelmaking process in electric arc furnace (2014)

Hexavalent chromium (Cr(VI)) is well-known to be a strong oxidizer, and is recognized as a carcinogen. Therefore, it is regulated for drinking water, soil, groundwater and sea by the environmental quality standards all over the world. In this study, it was attempted to remove Cr(VI) ion in a carbonic acid solution by the oxidizing slag that was discharged from the normal steelmaking process in an electric arc furnace. After the addition of the slag into the aqueous solution contained Cr(VI) ion, concentrations of Cr(VI) ion and total chromium (Cr(VI) + trivalent chromium (Cr(III)) ions decreased to lower detection limit of them. Therefore, the used slag could reduce Cr(VI) and fix Cr(III) ion on the slag. While Cr(VI) ion existed in the solution, iron did not dissolve from the slag. From the relation between predicted dissolution amount of iron(II) ion and amount of decrease in Cr(VI) ion, the Cr(VI) ion did not react with iron(II) ion dissolved from the slag. Therefore, Cr(VI) ion was removed by the reductive reaction between Cr(VI) ion and the iron(II) oxide (FeO) in the slag. This reaction progressed on the newly appeared surface of iron(II) oxide due to the dissolution of phase composed of calcium etc., which existed around iron(II) oxide grain in the slag
PON Test Systems – From theory to field deployments (2011)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. Ponchon and A. Champavère, "PON Test Systems – From theory to field deployments," in Optical Fiber Communication Conference/National Fiber Optic Engineers Conference 2011, OSA Technical Digest (CD) (Optica Publishing Group, 2011), paper NMD3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Advanced optical signal processing of broadband parallel data signals (2016)

Optical signal processing may aid in reducing the number of active components in communication systems with many parallel channels, by e.g. using telescopic time lens arrangements to perform format conversion and allow for WDM regeneration.
Suture wear particles cause a significant inflammatory response in a murine synovial airpouch model (2018)

There were no differences observed between the biological reactivity of commonly used intact orthopaedic sutures A, B, and C. However, wear particles of suture C elicited a significantly greater inflammatory response than intact suture alone. This was confirmed by increased numbers of multinucleated giant cells as well as MMP ( -1,-2,-9,-13) expression. Further studies are needed to determine whether this inflammatory response may play a role in the development of post-arthroscopic glenohumeral chondrolysis or interfere with biological healing. These findings have important clinical implications relating to surgical technique and surgical implant design.
Molecular genetic evidence for the involvement of a specific polygalacturonase, P2c, in the invasion and spread of Aspergillus flavus in cotton bolls (1997)

Isolates of Aspergillus flavus can be differentiated based on production of the polygalacturonase P2c. One group of isolates produces P2c, whereas the other group does not. In general, the group that produces P2c causes more damage and spreads to a greater extent in cotton bolls than those isolates that do not produce P2c. To determine whether P2c contributes to disease, the expression of pecA, the gene previously determined to encode P2c, was genetically altered. Adding the pecA gene to a strain previously lacking the gene resulted in the ability to cause significantly more damage to the intercarpellary membrane and the ability spread to a greater extent within the adjacent locule compared to the abilities of a control transformant. Conversely, eliminating the expression of pecA by targeted disruption caused a significant reduction in aggressiveness compared to that of a nondisrupted control transformant. These results provide direct evidence that P2c contributes to the invasion and spread of A. flavus during infection of cotton bolls. However, other factors not evaluated in this study also contribute to aggressiveness.