gebhart/patrepeval huggingface dataset:
AutoGraph: Predicting Lane Graphs from Traffic Observations (2023)

Lane graph estimation is a long-standing problem in the context of autonomous driving. Previous works aimed at solving this problem by relying on large-scale, hand-annotated lane graphs, introducing a data bottleneck for training models to solve this task. To overcome this limitation, we propose to use the motion patterns of traffic participants as lane graph annotations. In our AutoGraph approach, we employ a pre-trained object tracker to collect the tracklets of traffic participants such as vehicles and trucks. Based on the location of these tracklets, we predict the successor lane graph from an initial position using overhead RGB images only, not requiring any human supervision. In a subsequent stage, we show how the individual successor predictions can be aggregated into a consistent lane graph. We demonstrate the efficacy of our approach on the UrbanLaneGraph dataset and perform extensive quantitative and qualitative evaluations, indicating that AutoGraph is on par with models trained on hand-annotated graph data. Model and dataset will be made available at redacted-for-review.
Divergent Motifs but Overlapping Binding Repertoires of Six HLA-DQ Molecules Frequently Expressed in the Worldwide Human Population (2010)

Knowledge of the binding repertoires and specificities of HLA-DQ molecules is somewhat limited and contradictory, partly because of the scarcity of reports addressing some of the most common molecules and possibly because of the diversity of the techniques used. In this paper, we report the development of high-throughput binding assays for the six most common DQ molecules in the general worldwide population. Using comprehensive panels of single substitution analogs of specific ligands, we derived detailed binding motifs for DQA1*0501/DQB1*0301, DQA1*0401/DQB1*0402, and DQA1*0101/DQB1*0501 and more detailed motifs for DQA1*0501/DQB1*0201, DQA1*0301/DQB1*0302, and DQA1*0102/DQB1*0602, previously characterized on the basis of sets of eluted ligands and/or limited sets of substituted peptides. In contrast to what has previously been observed for DR and DP molecules, DQ motifs were generally less clearly defined in terms of chemical specificity and, strikingly, had little overlap with each other. However, testing a panel of peptides spanning a set of Phleum pratense Ags, and panels of known DQ epitopes, revealed a surprisingly significant and substantial overlap in the repertoire of peptides bound by these DQ molecules. Although the mechanism underlying these apparently contradictory findings is not clear, it likely reflects the peculiar mode of interaction between DQ (and not DR or DP) molecules and their peptide ligands. Because the DQ molecules studied are found in >85% of the general human population, these findings have important implications for epitope identification studies and monitoring of DQ-restricted immune responses.
Synthesis of Cycloalkanones from Dienes and Allylamines Through C—H and C—C Bond Activation Catalyzed by a Rhodium(I) Complex. (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation (2010)

PTEN activation specifically in SMC is a common upstream regulator of multiple downstream events involved in pathological vascular remodelling, including proliferation, de-differentiation, and production of multiple cytokines.
Home M2M networks: Architectures, standards, and QoS improvement (2011)

It is envisioned that home networks will shift from current machine-to-human communications to the machine-to-machine paradigm with the rapid penetration of embedded devices in home surroundings. In this article, we first identify the fundamental challenges in home M2M networks. Then we present the architecture of home M2M networks decomposed into three subareas depending on the radio service ranges and potential applications. Finally, we focus on QoS management in home M2M networks, considering the increasing number of multimedia devices and growing visual requirements in a home area. Three standards for multimedia sharing and their QoS architectures are outlined. Cross-layer joint admission and rate control design is reported for QoS-aware multimedia sharing. This proposed strategy is aware of the QoS requirements and resilience of multimedia services. Illustrative results indicate that the joint design is able to intelligently allocate radio bandwidth based on QoS demands in resource-constrained home M2M networks.
ChemInform Abstract: Methane‐ and Difluoromethanediphosphonate Analogues of Geranyl Diphosphate: Hydrolysis‐Inert Alternate Substrates. (1987)

Abstract The reactions of compounds (I) with isopentenyl diphosphate catalyzed by avian liver farnesyl diphosphate synthetase, leading to farnesyl diphosphate as the exclusive product in each case, are studied kinetically using 3H and 14C radiolabel.
Gene therapeutics and gene therapy for cancer (1994)

Recent advances in molecular biology have opened new avenues of basic genetic engineering technology and have made possible the application of this technology in clinical human gene therapy. Replication-defective viral vectors and biocompatible materials, eg, liposomes, have been developed as vehicles to introduce potentially therapeutic genes into mammalian cells. Over the past 2 years, this technology has increased the possibilities for therapy in numerous genetic diseases. Approaches at the molecular level have also demonstrated that one of the mechanisms of human cancer development is overexpression of dominant oncogenes, expression of mutant oncogenes, or specific chromosomal deletions or mutations that induce inactivation of tumor-suppressor activity. This concept suggests that the introduction of antisense oncogenes and wild-type tumor-suppressor genes, eg, p53, could halt or reverse these mechanisms, thus having a therapeutic effect in cancer. Moreover, evidence that the immune system is capable of eliminating tumor cells in numerous animal models has suggested gene therapy approaches for the delivery of cytokines, which promote the activation of cytotoxic immune responses against the malignant tissue. The efficacy of these gene therapy protocols is now being evaluated in both animal model systems and clinical trials. This article reviews recent highlights in this rapidly evolving field.
Frequency response modeling of high voltage power line carrier systems (2004)

Power line carrier (PLC) systems used on high voltage transmission lines for protection purposes have been documented to be susceptible to destructive resonant conditions when excited by a harmonic source. However, previous research has not produced generalized modeling of the PLC systems suitable for predicting the frequency responses of the systems. This paper expands previous research by presenting state-space models of three common types of power line carrier systems. The models presented have been simplified and are suitable for calculating the frequency responses of the PLC systems with practical accuracy.
Insight on the Surface Structure Effect of Free Gold Nanorods on Glucose Electrooxidation (2013)

The physicochemical properties of noble metal such as gold strongly depend on their size, shape, and their surface structure composition. Gold NPs have been studied in electrocatalysis due to their unexpected activity toward the oxidation of organics. The chemical reactions studies on a well-defined shape provide fundamental data on the surface reactivity for understanding and designing novel catalytic materials. Therefore, different gold nanorods (GNRs) were synthesized by chemical growth process. The UV–vis spectroscopy and transmission electron microscopy measurements confirmed their well-defined shape and size distribution. Moreover, the under-potential of lead (UPD), which is a sensitive electrochemical surface characterization tool, has been used to assess GNRs crystallographic structure information. Additionally, the UPD of lead reveals that their crystallographic facets are affected by their growth process. Most importantly, the interaction between GNRs surface and the remaining capping agent (CTAB) adsorbed after cleaning process has a high effect on the lead deposition and also leads to a decrease in the electrochemical activity of GNRs. The activity of different GNRs toward glucose oxidation was also investigated. The correlation between the activity of these materials toward this reaction and their surface structure was established. It shows an enhancement of the electroactivity in the presence of (100) facets.
Friedel–Crafts alkylation catalysed by GaCl3-based liquid coordination complexes (2015)

The high activity and selectivity of liquid coordination complexes as catalysts in Friedel–Crafts alkylation of aromatics at ambient temperature with alphaolefins is demonstrated.
Interpreting optical flow (vision, dynamic scene analysis, generalized hough transform, multiple moving objects, segmentation) (1985)

A new approach for the interpretation of optical flow fields is presented. The flow field, which can be produced by a sensor moving through an environment with several, independently moving, rigid objects, is allowed to be sparse, noisy and partially incorrect. The approach is based on two main stages. In the first stage the flow field is partitioned into connected segments of flow vectors, where each segment is consistent with a rigid motion of a roughly planar surface. Such a segment is assumed to correspond to a part of only one rigid object. This initial organization of the data is utilized in the second stage without the assumption of planar surfaces, and segments are now grouped under the hypothesis that they are induced by a single rigidly moving object and/or by the camera motion. Each hypothesis is tested by searching for 3-D motion parameters which are compatible with all the segments in the corresponding group. Once the motion parameters are recovered, the relative environmental depth can be estimated as well. Experiments based on real and simulated data are presented. Two inherent ambiguities, which may arise due to the presence of noise in the flow field, are analyzed and demonstrated. First, motion parameters of the sensor or a moving object may be extremely difficult to estimate because there may exist a large set of significantly incorrect solutions which induce flow fields similar to the correct one. Second, the decomposition of the flow field into sets corresponding to independently moving objects may be ambiguous because two such objects may induce optical flows which are compatible with the same motion parameters. These ambiguity analyses are general in the sense that they are algorithm-independent. Constraints and parameters which can be recovered even in ambiguous situations are presented.
High-Fidelity and Ultrafast Initialization of a Hole Spin Bound to a Te Isoelectronic Center in ZnSe (2016)

We demonstrate the optical initialization of a hole-spin qubit bound to an isoelectronic center (IC) formed by a pair of Te impurities in ZnSe, an impurity-host system providing high optical homogeneity, large electric dipole moments, and potentially advantageous coherence times. The initialization scheme is based on the spin-preserving tunneling of a resonantly excited donor-bound exciton to a positively charged Te IC, thus forming a positive trion. The radiative decay of the trion within less than 50 ps leaves a heavy hole in a well-defined polarization-controlled spin state. The initialization fidelity exceeds 98.5% for an initialization time of less than 150 ps.
Temperature insensitive high-precision refractive-index sensor using two concatenated dual-resonance long-period gratings (2013)

In this Letter we report on fabricating and analyzing a temperature insensitive refractometer based on two concatenated dual-resonance long-period gratings (LPGs) with an appropriate inter-grating space (IGS) in between. The IGS provides a temperature-dependent extra phase difference between the core and cladding modes, making the refractometer similar to a Mach-Zehnder interferometer with its arms phase shifted. We demonstrate that an appropriate IGS can produce temperature-insensitive resonance wavelengths. The interferometer is highly stable over a wide range of temperature (20°C-100°C). The measured refractive index sensitivity for aqueous solutions (1.333-1.343) is ~2583 nm/RIU, which is the highest reported so far for biological samples. The interferometer can be used for various other temperature-immune sensing applications also.
A prospective study of the rate of progression in compensated, histologically advanced chronic hepatitis C (2011)

Among patients with advanced hepatitis C who failed peginterferon and ribavirin therapy, the rate of liver-related outcomes, including death and liver transplantation, is high, especially once the CTP score reaches at least 7.
Pimecrolimus 1% Cream in Non-Specific Inflammatory Recurrent Balanitis (2007)

Pimecrolimus 1% cream is promising in relieving symptoms and signs of non-specific balanitis during flares and controlling the disease during long-term follow-up.
PW performance ion acceleration from the LANL 200TW Trident laser facility (2009)

The high contrast front-end for the 200 TW Trident laser has shown in recent experiments the importance roles that Amplified Spontaneous Emission (ASE) and prepulse contrast play in laser-ion acceleration. Ion energies above 58 MeV with efficiencies of greater than 5% into ions above 4 MeV have been observed. Scalings for, laser energy, intensity, and target thickness are presented and compared to other empirical scalings and theories, including results of the new ultra-high contrast >10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-10</sup> Optical Parametric Chirped-Pulse Amplification (OPCPA) front-end system.
Increased Expression of Activation‐Induced Cytidine Deaminase is Associated with Anti‐CCP and Rheumatoid Factor in Rheumatoid Arthritis (2009)

Rheumatoid arthritis (RA) is associated with higher levels of autoantibodies and IL-17. Here, we investigated if ectopic lymphoid follicles and peripheral blood mononuclear cells (PBMCs) from RA patients exhibit increased activation-induced cytidine deaminase (AID), and if increased AID is correlated with serum levels of autoantibodies and IL-17. The results of immunohistochemical staining showed that organized AID(+) germinal centres were observed in six of the 12 RA synovial samples, and AID(+) cells were found almost exclusively in the B-cell areas of these follicles. Aggregated but not organized lymphoid follicles were found in only one OA synovial sample without AID(+) cells. Significantly higher levels of AID mRNA (Aicda) detected by RT-PCR were found in the PBMCs from RA patients than PBMCs from normal controls (P < 0.01). In the PBMCs from RA patients, AID was expressed predominately by the CD10(+)IgM(+)CD20(+) B-cell population and the percentage of these cells that expressed AID was significantly higher than in normal controls (P < 0.01). AID expression in the PBMCs correlated significantly and positively with the serum levels of rheumatoid factor (RF) (P </= 0.0001) and anti-cyclic citrullinated peptide (CCP) (P = 0.0005). Serum levels of IFN-gamma (P = 0.0005) and IL-17 (P = 0.007), but not IL-4, also exhibited positive correlation with the expression of AID. These results suggest that the higher levels of AID expression in B cells of RA patients correlate with, and may be associated with the higher levels of T helper cell cytokines IFN-gamma and IL-17, leading to the development of anti-CCP and RF.
THE INTERACTION OF THE FACTOR VIII/vWF COMPLEX WITH IMMOBILISED METAL AFFINITY CHROMATOGRAPHY (IMAC) MATRICES (1987)

1MAC principles were used to investigate the binding of Factor VIII/vWF from either Al(OH)3 - absorbed citrated PPP or cryoprecipitate using citrate-saline buffers. Factor VIII/ vWF showed high affinity for both Zn2+ - or Cu2+ - immobilised on biscarboxymethylaminoSepharose 4B at ambient room temperature, but no interaction with Ca2+, Mg2+, Mn2+ or Cd2+ - immobilised matrices. Factor VIII/vWF could be re-eluted as a single component from Zn2+ - columns using either decreasing pK, or increasing competitor ligandconcentrations. In pK gradients comprising 14mM citrate, 2.14mM CaCl2, 0.15m NaCl Factor VIII eluted at pH 6.50, whereas in pH gradients comprising 0.1m Tris, 2.5mM CaCl2 pH 7.5 and 0.1M succinate, 2.5mM CaCl2 pH 5.5 Factor VIII eluted at pH 6.06. Citrate behaves as a competitor ligand; at 4° in citrate buffer Factor VIII did not bind. In citrate-saline buffers pH 7.2 Factor VIII could be reeluted in high yield (100% Factor VIII:Ag; 70% VIII:C; 90% vWF:Ag) through application of linear competitor ligand gradients (at 11.5mM imidazole, 15.4mM dl-Eistidine, 45mM L-Lysine, or 1.7% BSA) , whereas 1.0M NaCl or 1.0M NH4Cl were ineffective. The Factor VIII activities co-eluted ahead of, but incompletely resolved from the re-eluted Fg and Fn. If 5 mg/ml. BSA was incorporated into the buffers Factor VIII was quantitatively recovered in the column wash - through fractions leaving all the Fg and Fn bound to the matrix.
Leveraging Anisotropy for Coupled Optimization of Thermal Transport and Light Transmission in Micro‐Structured Materials for High‐Power Laser Applications (2020)

Abstract Maximum operating power densities in ceramic laser media scale with thermal conductivity k . This requires larger grain sizes in polycrystalline ceramics to reduce phonon scattering at grain boundaries. However, smaller grain sizes are preferred to minimize light scattering in the Rayleigh regime in polycrystals made from birefringent materials such as AlN and Al 2 O 3 , which are otherwise appealing for their high k . An optimization challenge arises from the opposite scaling laws governing the effects of grain sizes on k and light transmission. Here, this is tackled by introducing anisotropically microstructured materials (columnar/disk‐shaped grains) as the lasing media, and allowing orthogonal heat transfer and lasing directions. For columnar grains, larger grain sizes along the c ‐axis help maintain high k for good heat dissipation, while preserving light transmission properties in the orthogonal lasing and pumping directions. Analytical models for the thermal conductivity in such structures are presented and verified using Monte‐Carlo ray‐tracing simulations. Similarly, an approximate Rayleigh–Gans–Debye model is used to predict light transmission and verified with exact simulations using FEM software. Finally, the tradeoff between thermal and optical phenomena is captured in a new anisotropic figure‐of‐merit tensor, which is optimized for the microstructure that maximizes lasing media performance in AlN and Al 2 O 3 model systems.
Establishing an accurate numerical model for the 2D-simulation of buried contact cells [solar cells] (2002)

An accurate numerical model is established for the simulation of buried contact solar cells in two dimensions. The physical parameters and the approximations are discussed as well as the procedures that lead to the foundations of the model. The model is applied to bifacial solar cells with three different rear surface configurations: passivated by a thermally grown oxide (A); by a dopand-induced floating junction (B); and with a contacted junction (C). Especially when the cell is situated in a light-concentrating roof tile, configuration C performed far better than A and B. The two-dimensional effects of resistive losses in the semiconductor region of the solar cell are also discussed.
Correction to: Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome (2019)

Following publication of the original article [1], the authors reported an error in Figure 4 as the wrong figure was used.
Efficient Byzantine Broadcast in Wireless Ad-Hoc Networks (2005)

This paper presents an overlay based Byzantine tolerant broadcast protocol for wireless ad-hoc networks. The use of an overlay results in a significant reduction in the number of messages. The protocol overcomes Byzantine failures by combining digital signatures, gossiping of message signatures, and failure detectors. These ensure that messages dropped or modified by Byzantine nodes will be detected and retransmitted and that the overlay will eventually consist of enough correct processes to enable message dissemination. An appealing property of the protocol is that it only requires the existence of one correct node in each one-hop neighborhood. The paper also includes a detailed performance evaluation by simulation.
Computed Tomography and Cardiac Magnetic Resonance in Ischemic Heart Disease (2016)

Ischemic heart disease is a complex disease process caused by the development of coronary atherosclerosis, with downstream effects on the left ventricular myocardium. It is characterized by a long preclinical phase, abrupt development of myocardial infarction, and more chronic disease states such as stable angina and ischemic cardiomyopathy. Recent advances in computed tomography (CT) and cardiac magnetic resonance (CMR) now allow detailed imaging of each of these different phases of the disease, potentially allowing ischemic heart disease to be tracked during a patient's lifetime. In particular, CT has emerged as the noninvasive modality of choice for imaging the coronary arteries, whereas CMR offers detailed assessments of myocardial perfusion, viability, and function. The clinical utility of these techniques is increasingly being supported by robust randomized controlled trial data, although the widespread adoption of cardiac CT and CMR will require further evidence of clinical efficacy and cost effectiveness.
System/360 and Beyond (1981)

The evolution of modern large-scale computer architecture within IBM is described, starting with the announcement of System/360 in 1964 and covering the latest extensions to System/370. Emphasis is placed on key attributes and on the motivation for providing them, and an assessment is made of the experience gained in the implementation and use of the architecture. The main approaches are discussed for obtaining implementations at widely differing performance levels, and a number of significant implementation parameters for all processors are listed.
Preclinical Activity of the Oral Proteasome Inhibitor MLN9708 in Myeloma Bone Disease (2014)

Given favorable data on pharmacologic properties and emerging clinical safety profile of MLN9708, it is conceivable that this proteasome inhibitor may achieve bone beneficial effects in addition to its antimyeloma activity in patients with myeloma.
Use of Sealed Grafts in the HeartMate II Left Ventricular Assist Device Inflow and Outflow Conduits (2014)

Gelatin-impregnated nonporous sealed grafts were introduced in the inflow and outflow conduits for use with the HeartMate II (HMII) to eliminate preclotting procedures and to reduce operative bleeding. We compared results of 67 patients who received first-time left ventricular assist devices (LVADs) with sealed inflow and outflow grafts (S-graft group) with a preceding 65 patients who received an LVAD with nonsealed grafts (NS-graft group). Overall, the amount of blood product transfusions was less in the S-graft group than that in the NS-graft group (red blood cells, 4.9 ± 4.5 vs. 8.0 ± 9.4 units, p = 0.022; fresh-frozen plasma, 5.0 ± 3.0 vs. 8.7 ± 9.3 units, p = 0.004; platelets, 2.9 ± 1.1 vs. 4.5 ± 3.5 units, p = 0.001; and cryoprecipitate, 1.2 ± 0.9 vs. 2.01 ± 1.9 units, p = 0.002). Within a follow-up period of 6 months, no device-related infections or strokes occurred in the S-group, but the NS-group had one (1.5%) driveline infections and four (6%) strokes. The 30 days survival rate was not significantly different between groups (p = 0.053), but favored the S-group (97%) over the NS-group (88%). Use of a HMII with a sealed graft on the inflow and outflow conduits is associated with less postoperative bleeding and may have helped to decrease the frequency of postoperative adverse events.