gebhart/patrepeval huggingface dataset:
Cobalt-Catalyzed Stereoretentive Hydrogen Isotope Exchange of C(sp3)–H Bonds (2017)

Cobalt dialkyl complexes bearing <i>α</i>-diimine ligands proved to be active precatalysts for the nondirected, C(sp<sup>3</sup>)-H selective hydrogen isotope exchange (HIE) of alkylarenes using D<sub>2</sub> gas as the deuterium source. Alkylarenes with a variety of substitution patterns and heteroatom substituents on the arene ring were successfully labeled, enabling high levels of incorporation into primary, secondary, and tertiary benzylic C(sp<sup>3</sup>)-H bonds. In some cases, the HIE proceeded with high diastereoselectivity and application of the cobalt-catalyzed method to enantioenriched substrates with benzylic stereocenters provided enantioretentive hydrogen isotope exchange at tertiary carbons.
Voice user interface principles for a conversational agent (2004)

In this paper, we describe the user interface principles guiding the design of a conversational agent capable of speech enabling multiple applications, and provide a sample of its typical dialog.
Effect of rabbit antibodies against angiotensin‐II on the pressor response to angiotensin‐II and renal hypertension in the rat (1968)

1. In the intact or nephrectomized rat, the pressor responses to synthetic angiotensin-II-amide, beta-angiotensin-II and native "rat angiotensin" could be inhibited by intravenous injection of rabbit serum containing antibodies against synthetic angiotensin-II-amide.2. The pressor responses to vasopressin or noradrenaline were not influenced by anti-angiotensin serum.3. A single injection of anti-angiotensin serum inhibited the pressor responses to angiotensin-II-amide for a period of 2.5 hr.4. Intravenous infusion or daily intraperitoneal injection of anti-angiotensin serum did not influence blood pressure levels in renal hypertensive rats.
Unraveling multi-dimensional data using pDView (2011)

We present the pattern development view (pDView) system for multidimensional scientific data visualization. The pDView system relies on a novel pattern development tree (pDTree) structure to unravel patterns in multidimensional data without having to rely on visualizations that require either significant degrees of projections that eliminate certain dimensions at the expense of the others or introduce significant visual overhead due to overly-rich multi-dimensional graphic interfaces. Instead, pDView maps data along all its relevant dimensions onto a pDTree structure, capturing and visualizing the underlying fundamental relationships. The user is able to vary contextual parameters to observe the strength and robustness of these relationships under different situations.
Total Synthesis of (−)‐Ophiodilactone A and (−)‐Ophiodilactone B (2013)

Abstract The first asymmetric total synthesis of (−)‐ophiodilactone A and (−)‐ophiodilactone B, isolated from the ophiuroid (Ophiocoma scolopendrina), is reported. The key features of the synthesis include the highly stereocontrolled construction of the structurally congested γ‐lactone/δ‐lactone skeleton through an asymmetric epoxidation, diastereoselective iodolactonization, and intramolecular epoxide‐opening with a carboxylic acid, and biomimetic radical cyclization of ophiodilactone A to ophiodilactone B.
Analysis of grain-boundary electromigration (1978)

A general analysis for grain-boundary electromigration applicable for type-A, -B, and -C diffusion kinetics is presented. Following Whipple’s approach in analyzing grain-boundary diffusion, solutions for composition profiles have been derived for isolated boundaries (for type-B and -C kinetics) and for interacting boundaries (for type-A kinetics). Asymptotic expressions for the exact solution have been obtained using the method of steepest descents and conditions for their validity are specified. The asymptotic solutions with opposite driving forces can be linearly combined into two relationships which relate the slopes of the composition profiles directly to the grain-boundary diffusivity and the effective charge. These relationships provide useful formulas to analyze the edge profiles measured in cross-stripe experiments. Martin’s solution was found to provide a reasonable approximation for the composition profile within the valid range of the asymptotic solutions.
Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans. (1994)

In contrast to several inbred strains of mice that develop Th1-associated anticandidal protection, DBA/2 mice are highly susceptible to systemic infection with Candida albicans cells of the attenuated variant PCA-2, and fatal outcome is observed in concurrence with sustained CD4+ cell production in vitro of IL-4 and IL-10. These Th2 cytokines were previously shown to inhibit nitric oxide (NO) production and yeast killing by activated macrophage cultures. We now show that macrophages from DBA/2 mice, either intact or infected with PCA-2, have lower capacity than resistant strains to synthesize NO in response to IFN-gamma. However, when treated with anti-IL-10 Abs at the time of infection, DBA/2 mice survived challenge and displayed increased production of NO in vitro after IFN-gamma activation. Cure was associated with the onset of footpad responses and durable protection, and higher frequencies of IFN-gamma-secreting cells were found in splenic CD4+ lymphocytes that expressed lower levels of IL-4 and IL-10 mRNA. Therefore, in DBA/2 mice, IL-10 contributes significantly to the selection of a Th2 response and lethality after PCA-2 challenge. An IL-10-induced defect in the activation and/or expansion of IFN-gamma-producing Th1 cells, IL-10 suppression of yeast killing, and the relative inability of DBA/2 macrophages to produce adequate levels of candidacidal NO may all contribute to the abnormal susceptibility of these mice to candidiasis.
Creating segmented databases from free text for text retrieval (1991)

Article Free Access Share on Creating segmented databases from free text for text retrieval Authors: Lisa F. Rau Artificial Intelligence Laboratory, GE Research and Development Center, Schenectady, NY Artificial Intelligence Laboratory, GE Research and Development Center, Schenectady, NYView Profile , Paul S. Jacobs Artificial Intelligence Laboratory, GE Research and Development Center, Schenectady, NY Artificial Intelligence Laboratory, GE Research and Development Center, Schenectady, NYView Profile Authors Info & Claims SIGIR '91: Proceedings of the 14th annual international ACM SIGIR conference on Research and development in information retrievalSeptember 1991 Pages 337–346https://doi.org/10.1145/122860.122894Online:01 September 1991Publication History 8citation444DownloadsMetricsTotal Citations8Total Downloads444Last 12 Months11Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Video quality of experience in the presence of accessibility and retainability failures (2014)

Accurate Quality of Experience measurement for streaming video has become more crucial with the increase in demand for online video viewing. Quantifying video Quality of Experience is a challenging task. Significant efforts to quantify video Quality of Experience have primarily focused on the measurement of Quality of Experience for videos with network and compression related impairments. These impairments, however, may not always be the only main factors affecting Quality of Experience in an entire video viewing session. In this paper, we evaluate Quality of Experience for entire video viewing sessions, from the beginning to the end. In doing so, we evaluate videos with temporary interruptions as well as those with permanent interruptions or failures. We consider two types of failures, namely Accessibility and Retainability failures, and present the results of two subjective studies. These results indicate: (a) Accessibility and Retainability failures are rated lower compared to temporary interruption impairments; (b) Accessibility failures are rated close to the lowest value on the rating scale; and (c) the traditionally used 5-point scale to measure video Quality of Experience is not sufficient in the presence of Accessibility and Retainability failures.
Application of intrathecal trastuzumab for treatment of meningeal carcinomatosis in HER2-overexpressing metastatic breast cancer (2008)

1138 Background: When the humanized anti-HER2 monoclonal antibody trastuzumab is given intravenously, very little reaches the cerebrospinal fluid (CSF). Thus, carcinomatous meningitis may occur in patients with complete systemic remission induced by trastuzumab therapy. Intracerebral injections in rats with meningeal carcinomatosis have shown an increase in survival without clinical or histologic toxic effects. Three cases of meningeal dissemination from breast cancer treated with intrathecally administered trastuzumab have been reported clinically without any significant adverse events. Here we report a case of a 66-year-old woman with HER2-overexpressing metastatic breast cancer who suffered from meningeal carcinomatosis and was treated with intrathecal trastuzumab. Results: The patient developed invasive apocrine carcinomas (six involved nodes, hormone receptor-negative and HER2 3+) in her right breast and was initially treated with mastectomy and axillary nodal dissection followed by chemotherapy (CEF; cyclophosphamide, doxorubicine, and 5-fluorouracil followed by docetaxel) and radiotherapy (50 Gy). Two years later, the patient had episodes of vertigo and headaches. MRI and CSF analysis indicated brain metastasis and meningeal carcinomatosis without any metastatic lesions other than these metastatic sites. An Ommaya reservoir for intrathecal treatment with methotrexate and cytarabine was placed surgically, and the patient was treated with intrathecal chemotherapy and whole-brain radiotherapy (40Gy). Meningeal enhancement and brain tumor on MRI and tumor cell counts in CSF still remained after the maximal treatment cycle. As the next choice of treatment, intrathecal therapy with weekly trastuzumab (25 mg/body) was begun after approval of IRB. After 6 injections of trastuzumab, malignant cells in CSF disappeared and interestingly the brain tumor shrank. The patient still continues intrathecal trastuzumab without any clinical toxic effects. Conclusions: Considering the few options for treatment of meningeal dissemination in MBC, this approach might be a viable method of treatment for meningeal dissemination of HER2-positive MBC patients through appropriate clinical trials. No significant financial relationships to disclose.
Noise figure of saturated 1310-nm polarization insensitive multiple-quantum-well optical amplifiers (1996)

The noise figure degradation due to saturation by amplified spontaneous emission of high-gain 1310-nm polarization insensitive multiple-quantum-well optical amplifiers has been investigated systematically by studying amplifiers of different lengths. It is found that the intrinsic noise figure of 4 dB of a device with 20-dB single-pass gain is degraded to about 5 dB for a device having 36-dB single-pass gain. This degradation in noise figure is very modest, compared to results reported earlier for semiconductor optical amplifiers with bulk-gain media, illustrating the benefits of using a quantum-well gain medium in semiconductor optical amplifiers.
Definition of terms relating to the non-ultimate mechanical properties of polymers (Recommendations 1998) (1998)

Abstract
Complexes of 1,2-bis(aryl-imino)acenaphthene (Ar-BIAN) ligands with some heavy p-block elements (2006)

The new Ar-BIAN complexes [(mes-BIAN)InCl(3)(THF)] (1), [(mes-BIAN)(2)Tl][PF(6)] (2), [(dipp-BIAN)SnCl(4)] (3), [(dipp-BIAN)SbCl(3)] (4), [(dipp-BIAN)BiCl(3)] (5) and [(mes-BIAN)BiCl(3)] (6) have been prepared by treatment of the neutral mes- and dipp-substituted BIAN ligands with the p-block reagents InCl(3), TlPF(6), SnCl(4), SbCl(3), and BiCl(3). The molecular structures of complexes 1-6 have been determined by single-crystal X-ray diffraction methods. However, only the atom connectivity was established for 5.
Conclusion: rethinking the implications of EMNEs' rise (2013)

The aim of this book has been to better understand the extent, nature and roots of the competitive advantage of emerging market multinational enterprises (EMNEs) and, in particular, the ways in which their internationalisation is contributing to the enhancement of that competitive advantage. To do so we examined three, inter-related factors that might potentially help EMNEs build competitive advantage: innovation, value-chain configuration and cross-border mergers and acquisitions (M&A); we compared and contrasted the experience of firms from each of the BRIC countries (Brazil, Russia, India and China). We now step back to draw some conclusions from this analysis.
Barium: An Efficient Cathode Layer for Bulk-heterojunction Solar Cells (2013)

We report Barium (Ba) cathode layer for bulk-heterojunction solar cells which enhanced the fill factor (FF) of p-DTS(FBTTh2)2/PC71BM BHJ solar cell up to 75.1%, one of the highest value reported for an organic solar cell. The external quantum efficiency exceeds 80%. Analysis of recombination mechanisms using the current-voltage (J-V) characteristics at various light intensities in the BHJ solar cell layer reveals that Ba prevents trap assisted Shockley-Read-Hall (SRH) recombination at the interface and with different thicknesses of the Ba, the recombination shifts towards bimolecular from monomolecular. Moreover, Ba increases shunt resistance and decreases the series resistance significantly. This results in an increase in the charge collection probability leading to high FF. This work identifies a new cathode interlayer which outclasses the all the reported interlayers in increasing FF leading to high power conversion efficiency and have significant implications in improving the performance of BHJ solar cells.
Impact of high-temperature implantation of Mg ions into GaN (2020)

Abstract Magnesium (Mg) ion implantation into gallium nitride (GaN) at 1000 °C is proposed. Since ion implantation and annealing occur simultaneously in high-temperature implantation, it is considered that Mg ions can be introduced at an appropriate position upon their implantation. GaN vertical diodes implanted with Mg ions were fabricated and current–voltage measurements were performed. As a result, clear rectifying properties were confirmed in a sample that was implanted with Mg ions at 1000 °C and annealed after implantation. However, the sample subjected to Mg ion implantation at RT and annealed after implantation showed no clear rectification. These results show that high-temperature implantation of Mg ions at 1000 °C reduces Mg ion implantation-induced damage and simultaneously activates Mg ions upon their implantation.
The role of functional phosphoric acid ester monomers in the surface treatment of yttria-stabilized tetragonal zirconia polycrystals (2017)

This study aimed to evaluate the bond strength of a resin cement to yttria-stabilized tetragonal zirconia polycrystals (Y-TZPs) treated with three different phosphate functional monomers containing primers by measuring the water contact angle. Seventy Y-TZP discs were divided into seven experimental groups (n=10), including an untreated (control) group. Specimens were treated with one of the following monomers: MDP (MD), GPDM (GP), and Phenyl-P (PP). After primer application and air drying, half the treated specimens were ultrasonically cleaned in ethanol for 2 min (MD-e, GP-e, and PP-e), and contact angles were measured. The tensile bond strength test was performed after storage for 24 h in 37°C water. The contact angle on the MD-e surface (64°) was significantly higher than that on the Con, GP-e, and PP-e surfaces (51°-52°). The application of the MDP-containing primer resulted in significantly higher bond strength between Y-TZP ceramics and a resin cement.
Dependence of Chromatosome Structure on Linker Histone Sequence and Posttranslational Modification (2018)

Linker histone (LH) proteins play a key role in higher-order structuring of chromatin for the packing of DNA in eukaryotic cells and in the regulation of genomic function. The common fruit fly (Drosophila melanogaster) has a single somatic isoform of the LH (H1). It is thus a useful model organism for investigating the effects of the LH on nucleosome compaction and the structure of the chromatosome, the complex formed by binding of an LH to a nucleosome. The structural and mechanistic details of how LH proteins bind to nucleosomes are debated. Here, we apply Brownian dynamics simulations to compare the nucleosome binding of the globular domain of D. melanogaster H1 (gH1) and the corresponding chicken (Gallus gallus) LH isoform, gH5, to identify residues in the LH that critically affect the structure of the chromatosome. Moreover, we investigate the effects of posttranslational modifications on the gH1 binding mode. We find that certain single-point mutations and posttranslational modifications of the LH proteins can significantly affect chromatosome structure. These findings indicate that even subtle differences in LH sequence can significantly shift the chromatosome structural ensemble and thus have implications for chromatin structure and transcriptional regulation.
Music Therapy in Japan (1991)

Music Therapy in Japan Get access Cheryl Dileo Maranto Cheryl Dileo Maranto Temple University Search for other works by this author on: Oxford Academic PubMed Google Scholar Music Therapy Perspectives, Volume 9, Issue 1, 1991, Page 106, https://doi.org/10.1093/mtp/9.1.106 Published: 01 January 1991
Partially coherent illumination in interferometers for optical testing (1998)

In the last few years one can observe a renaissance of partially coherent illumination in interferometers. The reason behind is the roughening of wavefronts due to dust diffraction, inhomogeneities, and the remaining micro-roughness of all optical components within the light path. Illumination with the TEM 00 mode of a laser will show these effects in the interference pattern rather clearly /1/. Because of the heterodyne advantage of interferometry small scattered light amplitudes result in rather pronounced modulations of the lateral intensity distribution of the laser beam and inevitably give rise to small lateral phase modulations on the order of 1/100 of a light wave. These small phase variations can easily be detected in a laser interferogram even if the light has carefully been filtered with the help of a pinhole in the collimation optics. The amount of phase uncertainty introduced in the measurement of surface shapes and other parameters of optical components depends on the type of interferometer as well as the amount of tilt fringes in the interferogram.
High‐temperature magnetic properties of anisotropic MnBi/NdFeB hybrid bonded magnets (2015)

Abstract Anisotropic MnBi/NdFeB (MnBi contents of 0 wt%, 20 wt%, 40 wt%, 60 wt%, 80 wt%, and 100 wt%) hybrid bonded magnets were prepared by molding compression using MnBi powders and commercial hydrogenation disproportionation desorption and recombination (HDDR) NdFeB powders. Magnetic measurements at room temperature show that with MnBi content increasing, the magnetic properties of the MnBi/NdFeB hybrid bonded magnets all decrease gradually, while the density of the hybrid magnets improves almost linearly. In a temperature range of 293–398 K, the coercivity temperature coefficient of the hybrid magnets improves gradually from −0.59 %·K −1 for the pure NdFeB bonded magnet to −0.32 %·K −1 for the hybrid bonded magnet with 80 wt% MnBi, and the pure MnBi bonded magnet exhibits a positive coercivity temperature coefficient of 0.61 %·K −1 .
Crossover Pharmacokinetic Analysis Comparing Intravenous and Intraperitoneal Administration of Tobramycin (1986)

Journal Article Crossover Pharmacokinetic Analysis Comparing Intravenous and Intraperitoneal Administration of Tobramycin Get access J. J. Walshe, J. J. Walshe Departments of Medicine and Pharmacy, State University of New York at Buffalo, Erie County Medical Center, Buffalo, New York Please address requests for reprints to Dr. John J. Walshe, Department of Medicine, Renal Division, SUNY at Buffalo, Erie County Medical Center, 462 Grider Street, Buffalo, New York 14215. Search for other works by this author on: Oxford Academic PubMed Google Scholar G. D. Morse, G. D. Morse Departments of Medicine and Pharmacy, State University of New York at Buffalo, Erie County Medical Center, Buffalo, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar D. M. Janicke, D. M. Janicke Departments of Medicine and Pharmacy, State University of New York at Buffalo, Erie County Medical Center, Buffalo, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar M. A. Apicella M. A. Apicella Departments of Medicine and Pharmacy, State University of New York at Buffalo, Erie County Medical Center, Buffalo, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 153, Issue 4, April 1986, Pages 796–799, https://doi.org/10.1093/infdis/153.4.796 Published: 01 April 1986 Article history Received: 27 June 1985 Revision received: 15 November 1985 Published: 01 April 1986
1H and 13C NMR spectral assignments of 2,4‐diaryl‐substituted cycloalkyl[d]pyrimidines (2002)

Abstract The proton and carbon spectra of new 2,4‐diaryl‐substituted cycloalkyl[ d ]pyrimidines prepared in a simple one‐pot reaction, are reported. Copyright © 2002 John Wiley &amp; Sons, Ltd.
Chemoprevention of Indirect and Direct Chemical Carcinogenesis by Carotenoids as Oxygen Radical Quenchersa (1988)

Beta-carotene (BC) and canthaxanthine (CX), two carotenoids with and without pro-vitamin A activity, respectively, were found to help to prevent benzo[a]pyrene (BP)-induced skin carcinogenesis in the dark and BP photocarcinogenesis (UV 300-400 nm) when given as an oral supplement to female Swiss albino mice. The same experimental procedure was adapted to 8-methoxypsoralen (8-MOP) photoinduction of mammary carcinomas in mice. Here also, the two carotenoids were strongly antitumorigenic. Indeed, 8-MOP photomutagenesis, tested in S. typhimurium TA 102, appeared to depend on a two-step reaction, namely an oxygen-independent DNA-8-MOP photoadduct, followed by an oxygen-dependent second step, sensitive to carotenoids. This result suggests that dietary carotenoids (powerful antioxidant molecules) might prevent the carcinogenic risk caused by substances that are transformed into ultimate carcinogens by oxidative processes which are indirectly carcinogenic. Finally, to verify whether supplemental carotenoids can affect carcinogenesis where neither light excitation nor oxidative metabolic processes are involved, an experimental attempt was made on gastric carcinogenesis induced in rats by the direct carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The results demonstrate that supplemental carotenoids do not affect initiation and progression stages, but do prevent the progression stage of dysplasias to infiltrating gastric carcinomas. Thus, this provides strong presumptive evidence for oxygen radical involvement in the later stages of this neoplastic development, as recently reported in the literature. As far as mutagenicity in S. typhimurium is concerned, carotenoids do not exert, as expected, any protective effect on MNNG mutagenic activity. The above experimental data suggest that supplemental carotenoids, instead of sunscreen preparations, can be adopted by outdoor workers to prevent skin cancer. Accordingly, such natural antioxidants may be useful in human chemoprevention against neoplasias of the lung, breast, urinary bladder, and colon and rectum even after radical surgery.