gebhart/patrepeval huggingface dataset:
Diplacone Isolated from Paulownia tomentosa Mature Fruit Induces Ferroptosis-Mediated Cell Death through Mitochondrial Ca2+ Influx and Mitochondrial Permeability Transition (2023)

The recently defined type of cell death ferroptosis has garnered significant attention as a potential new approach to cancer treatment owing to its more immunogenic nature when compared with apoptosis. Ferroptosis is characterized by the depletion of glutathione (GSH)/glutathione peroxidase-4 (GPx4) and iron-dependent lipid peroxidation. Diplacone (DP), a geranylated flavonoid compound found in <i>Paulownia tomentosa</i> fruit, has been identified to have anti-inflammatory and anti-radical activity. In this study, the potential anticancer activity of DP was explored against A549 human lung cancer cells. It was found that DP induced a form of cytotoxicity distinct from apoptosis, which was accompanied by extensive mitochondrial-derived cytoplasmic vacuoles. DP was also shown to increase mitochondrial Ca<sup>2+</sup> influx, reactive oxygen species (ROS) production, and mitochondrial permeability transition (MPT) pore-opening. These changes led to decreases in mitochondrial membrane potential and DP-induced cell death. DP also induced lipid peroxidation and ATF3 expression, which are hallmarks of ferroptosis. The ferroptosis inhibitors ferrostatin-1 and liproxstatin-1 were effective in counteracting the DP-mediated ferroptosis-related features. Our results could contribute to the use of DP as a ferroptosis-inducing agent, enabling studies focusing on the relationship between ferroptosis and the immunogenic cell death of cancer cells.
Crystal structure of the growth surface of silicon carbide obtained by sublimation (2007)

Structural study of polycrystalline silicon carbide obtained by sublimation performed via X-ray luminescence and X-ray diffraction analysis. It is shown that chemical vapor deposition of silicon carbide results in the formation of grains with the (00.1), (01.1), and (12.3) crystallographic planes parallel to the growth surface. The grains with the (00.1) growth planes are characterized by perfect structure and by red luminescence. Domains with yellow luminescence have a mosaic structure with the (01.1) and (12.3) growth planes.
Output-Boundary Regulation for Nonlinear Nonminimum-Phase Systems (2016)

Exact output tracking requires preview information of the desired output for nonminimum-phase systems. For situations when preview information is not available, this article proposes an output-boundary regulation (OBR) approach that maintains the output-tracking error within prescribed bounds for nonlinear nonminimum-phase systems. OBR transitions the output-tracking error to zero whenever the output error reaches a set magnitude using polynomial output trajectories for each transition. The main contribution is to show that an output-transition-based OBR (O-OBR, which uses post-actuation input to transition the system state after the output-error transition is completed) can enable OBR of more aggressive output trajectories when compared to a state-transition-based OBR (S-OBR) that transitions the full system state and therefore achieves the output transition as well. Results from an example simulation system is used to illustrate the proposed OBR approach and comparatively evaluate the S-OBR and O-OBR approaches, which show that, for the example system, the O-OBR can track 3 times faster desired output trajectory than the S-OBR approach.
A Phase I and pharmacokinetic study of high dose tamoxifen and weekly cisplatin in patients with metastatic melanoma (1997)

A TAM dose of 240 mg/day is the recommended Phase II dose. Based on the 38.5% overall response rate at this dose, the authors have initiated a Phase II study.
Polymorphisms in the P450 c17 (17-Hydroxylase/17,20-Lyase) and P450 c19 (Aromatase) Genes: Association with Serum Sex Steroid Concentrations and Bone Mineral Density in Postmenopausal Women (2004)

The CYP 17 and CYP 19 genes encode 17alpha-hydroxylase/17,20-lyase and aromatase, respectively, both involved in sex hormone synthesis. We investigated the association between 2 common polymorphisms in 1) the promoter region (T-->C substitution) of CYP 17, and 2) exon 3 (G-->A) of CYP 19, bone mineral density (BMD) and serum androgen/estradiol, in a case-control study of 252 postmenopausal women aged 64.5 +/- 9.2 yr (mean +/- SD). There was no significant difference in serum estradiol concentrations between cases (n = 136) and controls (n = 116). The CYP 19 genotype was significantly associated with serum estradiol (P = 0.002). Women with the AA genotype had higher serum estradiol concentrations compared with those with the GG genotype (P = 0.03). In older women, those with the CYP 19 GA and GG genotypes had an increased prevalence of osteoporosis (P = 0.04) and fractures (P = 0.003). We found no significant association between CYP 17 genotype and serum androgens and estradiol concentrations. However, a significant association was seen between BMD values at the femoral neck with CYP 17 genotype in cases (P = 0.04) and in the whole study population (P = 0.012). Subjects with the CC genotype had significantly lower BMD (mean +/- SD: TT, 0.7 +/- 0.16; CC, 0.6 +/- 0.08 g/cm(2); P = 0.006). In conclusion, both CYP 17 and CYP 19 are candidate genes for osteoporosis in postmenopausal women.
RoonRoon: A Wearable Teddy as Social Interface for Contextual Notification (2007)

In this paper we present a wearable teddy, RoonRoon (a physical embodiment artefact) that acts as a user interface for information services. It can monitor user's physical activity state (walking, standing, running and sitting) and can provide personalized information in a contextual manner minimizing interruptions. RoonRoon has four notification mechanisms: audible beeps, human voice, ambient sound and vibration. Since RoonRoon is intended primarily for mobile use, interaction is managed completely by voice using natural language. This paper describes the design and implementation of RoonRoon. We also present an informal study that reveals end users' impressions towards wearable toys as social interfaces.
Multithread implementation for calculating room impulse responses. (2008)

Modern simulation programs are committed to calculate full impulse responses instead of doing simple mapping presentations. The main problem here is how to obtain such IRs quickly but accurately. The usual algorithm simulates sound propagation by tracing a statistical ensemble of acoustic rays. In this contribution, we deal with a new ray-triangle intersection algorithm, based on a three-dimensional grid scheme, that provides significant performance improvement for ray tracing. We report about the introduction of a uniform grid ray-tracing algorithm, which is optimized for acoustic models and can be up to five times faster (standard Pentium 4) than hierarchical space decomposition. Furthermore, the algorithm has been parallelized, taking advantage of the inherently independent propagation of distinct rays. On multicore processors, the computation employs a variable number of thread tracing groups of rays in parallel. The speed increase is almost linear with the number of cores. An overview is given to explain this approach. To support this fast calculation, an additional algorithm derives a suggested particle number and length from the mean free path properties of the room and the desired detection rate at the receiver. So time-consuming guesses about the selecting particle numbers will be avoided.
Study of InAsN quantum dots on GaAs substrates by molecular beam epitaxy (2006)

Abstract InAsN QDs on (001) GaAs substrates were studied. Each InAsN QD was surrounded by four {011} facets and had a pyramidal shape. However, InAs QDs had a half sphere shape. The InAsN QDs had size distributions with two maxima. This might be explained by the existence of very stable {011} facets and curved surfaces between the {011} facets. The curved surfaces act as the incorporation sites to grow the QD larger. This means that large InAsN QDs will be suppress the further growth, because of the smaller occupations of the curved surfaces to the total surface area of the InAsN QD. Excess In atoms supplied on the {001} plane will accumulate strains and form new small QDs by the Stranski–Krastanow (S–K) growth mode. This turns out two maxima of the size distribution. These results will open the possibility of obtaining the size control and small distributions of the InAsN QDs. We investigated the emission properties of these InAsN QDs. An emission peak of nearly 1300 nm from the InAsN QDs with a plasma power of 350 W was observed. InAsN QDs are an attractive material for achieving emissions in the fiber‐optic communication wavelengths. (© 2006 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Removal of Sulfur and Nitrogen Compounds from Diesel Oil by Adsorption Using Clays as Adsorbents (2017)

Stringent specifications for sulfur compounds content and the need to use oils with large amount of nitrogen compounds are challenges for fuel producers. Adsorption is an alternative process to remove sulfur and nitrogen compounds and clays are promising adsorbents for this removal. In this work, the adsorption performance of different commercial clays—Clay A (attapulgite), Clay B (bentonite), and Clay C (bentonite)—for the removal of sulfur and nitrogen compounds from a real diesel stream was studied through kinetic and isothermal experiments. The bentonite clays showed the best adsorptive capacity for the removal of sulfur and nitrogen compounds, probably due to the presence of Brønsted acid sites. The highest adsorption capacity was observed for Clay B: 0.174 mol kg–1 for sulfur compounds and 0.127 mol kg–1 for nitrogen compounds. Clay A was more selective to the removal of nitrogen compounds. Equilibrium data showed that adsorbate–absorbate and adsorbate–surface interactions predominate for sulfur and nitrogen compounds, respectively, for Clay A and Clay B.
Quantitative structure-activity relationships. 3. A comparison of different Free-Wilson models (1976)

The Fujita-Ban model and the classical Free-Wilson model are shown to be linearly related: the de novo group contributions obtained by one model are linear transformations of those obtained by the other model. An example is given to illustrate this linear dependence. The Fujita-Ban model is characterized by a number of advantages as compared with the classical Free-Wilson model: no transformation of the structural matrix and no symmetry equations are necessary; all group contributions are based on an arbitrarily chosen reference compound, preferably the unsubstituted compound; the constant term, which is the theoretically predicted activity value of the reference compound, and the values of the group contributions are not markedly influenced by addition or elimination of a compound; the problem of linear dependence (the singularity problem) sometimes can be circumvented by preparation of a contracted matrix; if the unsubstituted compound is chosen as reference compound, the group contributions are numerically equivalent to Hansch-derived group contributions; therefore, the Hansch approach and the Fujita-Ban model can be combined to a mixed approach. Taking all these facts into consideration, the Frujita-Ban model is recommended as the most suitable approach for the calculation of de novo group contributions.
A Double Precision High Speed Convolution Processor (1989)

There exist several convolution processors on the market that can process images at video rate. However, none of these processors operates in floating point arithmetic. Unfortunately, many image processing algorithms presently under development are inoperable in integer arithmetic, forcing the researchers to use regular computers. To solve this problem, we designed a specialized convolution processor that operates in double precision floating point arithmetic with a throughput several thousand times faster than the one obtained on regular computer. Its high performance is attributed to a VLSI double precision convolution systolic cell designed in our laboratories. A 9X9 systolic array carries out, in a pipeline manner, every arithmetic operation. The processor is designed to interface directly with the VME Bus. A DMA chip is responsible for bringing the original pixel intensities from the memory of the computer to the systolic array and to return the convolved pixels back to memory. A special use of 8K RAMs allows an inexpensive and efficient way of delaying the pixel intensities in order to supply the right sequence to the systolic array. On board circuitry converts pixel values into floating point representation when the image is originally represented with integer values. An additional systolic cell, used as a pipeline adder at the output of the systolic array, offers the possibility of combining images together which allows a variable convolution window size and color image processing.
Overcoming the Lack of Labeled Data: Training Intrusion Detection Models Using Transfer Learning (2019)

Deep learning (DL) techniques have recently been proposed for enhancing the accuracy of network intrusion detection systems (NIDS). However, keeping the DL based detection models up to date requires large amounts of new labeled training data which is often expensive and time-consuming to collect. In this paper, we investigate the viability of transfer learning (TL), an approach that enables transferring learned features and knowledge from a trained source model to a target model with minimal new training data. We compare the performance of a NIDS model trained using TL with a NIDS model trained from scratch. We show that TL enables detection models to perform much better at identifying new attacks when there is relatively less training data available.
Robust Mutual Information-Based Multi-Image Registration (2019)

Image registration is of crucial importance in image fusion such as pan-sharpening. Mutual information (MI)-based methods have been widely used and demonstrated effectiveness in registering multi-spectral or multi-modal images. However, MI-based methods may fail to converge in searching registration parameters, resulting mis-registration. In this paper, we propose an outlier robust method to improve the robustness of MI-based registration for multiple rigid transformed images. In particular, we first generate registration parameter matrices using a MI-based approach, then we decompose each parameter matrix into a low-rank matrix of inlier registration parameters and a sparse matrix corresponding to outlier parameter errors. Results of registering multi-spectral images with random rigid transformations show significant improvement and robustness of our method.
What's next for the Irish pub? (2020)

Canadian singer-songwriter Joni Mitchell's 1970’s hit "Big Yellow Taxi" had the immortal lines: "don’t it always seem to go/That you don’t know what you got/'Til its gone". With our favourite watering holes absent from our lives since mid-March - and perhaps some not reopening after a five-month hiatus until mid-August - these lyrics may resonate with many in how much we have taken our pubs for granted. When regular pub-goers do take their first tentative steps towards a socially distanced rendezvous with their local pub, it’s a reunion that may be quietly savoured by some, but one that’s postponed by others, punters and publicans alike.
Association of High Pretransplant sIL-6R Plasma Levels with Acute Tubular Necrosis in Kidney Graft Recipients (2006)

High pretransplant sIL-6R plasma levels are associated with an increased risk of ATN and might contribute to the development of ATN early posttransplant. Our data suggest that preactivation of the recipient's immune system increases the risk of ATN.
An NMR study of some substituted 1,3‐ and 1,4‐bistrifluoromethylbenzenes (1973)

Abstract Contrary to an earlier report, the metallation of 1,3‐bistrifluoromethylbenzene with n‐butyllithium is found to take place at the 4‐ and 2‐positions. Lithiation of 1,4‐bistrifluoromethylbenzene and subsequent carboxylation gives exclusively the 2‐carboxylic acid. Structures are assigned on the basis of PMR data (100 and 220 MHz). The effects of coupling between aromatic protons and trifluoromethyl groups and the aromatic chemical shifts brought about by esterification are discussed for a series of bistrifluoromethylbenzoic acids.
POSSIBLE INTRAFAMILIAL TRANSMISSION OF TOXOCARA CAUSING EOSINOPHILIC MENINGITIS IN AN INFANT (2008)

Human toxocariasis can result from the inadvertent ingestion of embryonated eggs of Toxocara canis or Toxocara cati from environmental sources such as dirt, sand, or foods carrying contaminated soil. We report a case in an infant resulting in eosinophilic meningitis and prolonged fever. The case illustrates probable intrafamilial transmission, a mode of transmission that has not been previously documented.
Two Novel Mitogen-Activated Protein Signaling Components, OsMEK1 and OsMAP1, Are Involved in a Moderate Low-Temperature Signaling Pathway in Rice (2002)

Rice (Oryza sativa) anther development is easily damaged by moderately low temperatures above 12 degrees C. Subtractive screening of cDNA that accumulated in 12 degrees C-treated anthers identified a cDNA clone, OsMEK1, encoding a protein with features characteristic of a mitogen-activated protein (MAP) kinase kinase. The putative OsMEK1 protein shows 92% identity to the maize (Zea mays) MEK homolog, ZmMEK1. OsMEK1 transcript levels were induced in rice anthers by 12 degrees C treatment for 48 h. Similar OsMEK1 induction was observed in shoots and roots of seedlings that were treated at 12 degrees C for up to 24 h. It is interesting that no induction of OsMEK1 transcripts was observed in 4 degrees C-treated seedlings. In contrast, rice lip19, encoding a bZIP protein possibly involved in low temperature signal transduction, was not induced by 12 degrees C treatment but was induced by 4 degrees C treatment. Among the three MAP kinase homologs cloned, only OsMAP1 displayed similar 12 degrees C-specific induction pattern as OsMEK1. A yeast two-hybrid system revealed that OsMEK1 interacts with OsMAP1, but not with OsMAP2 and OsMAP3, suggesting that OsMEK1 and OsMAP1 probably function in the same signaling pathway. An in-gel assay of protein kinase activity revealed that a protein kinase (approximately 43 kD), which preferentially uses myelin basic protein as a substrate, was activated by 12 degrees C treatment but not by 4 degrees C treatment. Taken together, these results lead us to conclude that at least two signaling pathways for low temperature stress exist in rice, and that a MAP kinase pathway with OsMEK1 and OsMAP1 components is possibly involved in the signaling for the higher range low-temperature stress.
Reversible splenial lesion syndrome due to oxcarbazepine withdrawal: case report and literature review (2018)

Background Reversible splenial lesion syndrome is a distinct entity radiologically characterized by a reversible lesion in the splenium of the corpus callosum. According to previous reports, this condition may be associated with antiepileptic drug use or withdrawal. We herein report a case of reversible splenial lesion syndrome associated with oxcarbazepine withdrawal. Case Report A 39-year-old man presented with an 8-year history of epileptic seizures. During the previous 3 years, he had taken oxcarbazepine irregularly. One week prior to admission, he withdrew the oxcarbazepine on his own, and the epilepsy became aggravated. Magnetic resonance imaging (MRI) revealed an isolated lesion in the splenium of the corpus callosum with slight hypointensity on T1-weighted imaging and slight hyperintensity on T2-weighted imaging. Regular oxcarbazepine was prescribed. Over a 5-month follow-up period, repeat MRI showed that the abnormal signals in the splenium of the corpus callosum had completely disappeared. Conclusion Reversible splenial lesion syndrome is a rare clinicoradiological disorder that can resolve spontaneously with a favorable outcome. Clinicians should be aware of this condition and that oxcarbazepine withdrawal is a possible etiological factor.
Optical Testing Using Laser Feedback Metrology (1990)

The sensitivity of laser diodes to small amounts of optical feedback provides the basis for a remarkably simple and versatile tool for interferometric metrology of optical elements and systems. The tool uses a simple optical scanner and phase tracking to analyse wavefronts and is particularly useful for obtaining surface profiles of strongly aspheric mirrors. Surface profiles have been obtained to an accuracy of 100 nm in the presence of extremely high (1011/mm) departures from spherical.
Power Flattening Techniques for Radioisotopic Thermoelectric Generators (1984)

The objective of this program was to investigation of a novel means of reducing the potential ecologic hazards that may be associated with radiosotopic thermoelectric generators (RTG's). A number of short lived isotopes have lower toxicities and are more ecologically acceptable than the Plutonium 238 used at present. In addition, the shorter half lives significantly reduce the time period during which isotope encapsulation must be assured (approximately 10 half lives). The technical approach involves the use of a gas controlled heat pipe to maintain a nearly constant heat input to the thermoelectric converter in spite of the decay profile of a short lived isotopic heat source. Excess thermal power available early in life, is automatically shorted around the thermoelectric module by way of the heat pipe. A development model of a gas controlled heat pipe capable of performing the required task was constructed and tested during this program.