gebhart/patrepeval huggingface dataset:
Bacillus thuringiensis plants expressing Cry1Ac, Cry2Ab and Cry1F are not toxic to the assassin bug, Zelus renardii (2014)

Abstract Cotton‐ and maize‐producing insecticidal crystal (Cry) proteins from the bacterium, Bacillus thuringiensis (Bt), have been commercialized since 1996. Bt plants are subjected to environmental risk assessments for non‐target organisms, including natural enemies that suppress pest populations. Here, we used Cry1F‐resistant Spodoptera frugiperda (J.E. Smith) and Cry1Ac and Cry2Ab‐resistant Trichoplusia ni (Hübner) as prey for the assassin bug, Zelus renardii (Kolenati), a common predator in maize and cotton fields. In tritrophic studies, we assessed several fitness parameters of Z. renardii when it fed on resistant S. frugiperda that had fed on Bt maize expressing Cry1F or on resistant T. ni that had fed on Bt cotton expressing Cry1Ac and Cry2Ab. Survival, nymphal duration, adult weight, adult longevity and female fecundity of Z. renardii were not different when they were fed resistant‐prey larvae ( S. frugiperda or T. ni ) reared on either a Bt crop or respective non‐Bt crops. ELISA tests demonstrated that the Cry proteins were present in the plant at the highest levels, at lower levels in the prey and at the lowest levels in the predator. While Z. renardii was exposed to Cry1F and Cry1Ac and Cry2Ab when it fed on hosts that consumed Bt‐transgenic plants, the proteins did not affect important fitness parameters in this common and important predator.
Information-theoretic feature extraction and selection for robust classification (2009)

Classification performance of recognition tasks can be improved by selection of highly discriminative features from the low-dimensional linear representation of data. High-dimensional multivariate data can be represented in lower dimensions by unsupervised feature extraction techniques which attempts to remove the redundancy in the data and/or resolve the multivariate prediction problems. These extracted low-dimensional features of raw data may not ensure good class discrimination, therefore, supervised feature selection methods motivated by information-theoretic approaches can improve the recognition performance with lesser number of features. Proposed hybrid feature selection methods efficiently selects features with higher class discrimination in comparison to feature-class mutual information (MI), Fisher criterion or unsupervised selection using variance; thus, resulting in much improved recognition performance. Feature-class MI criterion and hybrid feature selection methods are computationally scalable and optimal selectors for statistically independent features.
Natriuretic-like Peptide Lebetin 2 Mediates M2 Macrophage Polarization in LPS-Activated RAW264.7 Cells in an IL-10-Dependent Manner (2023)

Snake natriuretic peptide (NP) Lebetin 2 (L2) has been shown to improve cardiac function and reduce fibrosis as well as inflammation by promoting M2-type macrophages in a reperfused myocardial infarction (MI) model. However, the inflammatory mechanism of L2 remains unclear. Therefore, we investigated the effect of L2 on macrophage polarization in lipopolysaccharide (LPS)-activated RAW264.7 cells in vitro and explored the associated underlying mechanisms. TNF-α, IL-6 and IL-10 levels were assessed using an ELISA assay, and M2 macrophage polarization was determined by flow cytometry. L2 was used at non-cytotoxic concentrations determined by a preliminary MTT cell viability assay, and compared to B-type natriuretic peptide (BNP). In LPS-activated cells, both peptides reduced TNF-α and IL-6 release compared to controls. However, only L2 increased IL-10 release in a sustained manner and promoted downstream M2 macrophage polarization. Pretreatment of LPS-activated RAW264.7 cells with the selective NP receptor (NPR) antagonist isatin abolished both IL-10 and M2-like macrophage potentiation provided by L2. In addition, cell pretreatment with the IL-10 inhibitor suppressed L2-induced M2 macrophage polarization. We conclude that L2 exerts an anti-inflammatory response to LPS by regulating the release of inflammatory cytokines via stimulating of NP receptors and promoting M2 macrophage polarization through activation of IL-10 signaling.
The command of a wheelchair using thoughts and gaze (2012)

The goal of BEWHEELI project is to command and control a powered wheelchair throughout thoughts and gaze. For this purpose, a bi-modal real time collaborative system should be put in place, so it can enhance severely disabled people mobility in hostile indoor environment.
Tunable Frequency-Division Duplex RF Front End Using Electrical Balance and Active Cancellation (2018)

This paper presents a novel, tunable, frequency-division duplexing radio frequency (RF) front end that combines passive and active self-interference (SI) cancellation. An electrical-balance duplexer is used to passively cancel transmitter noise in the receive band, and an active canceller is employed to suppress SI in the transmit (Tx)-band. Subsystem specifications are developed, and a system-level analysis of noise and SI powers in this novel architecture is provided, thereby illustrating its operation. A proof-of-concept demonstrator, built from a software-defined radio and discrete RF components, has been characterized across a range of duplex configurations in the 700-950-MHz range and also at 1900 (Long-Term Evolution (LTE) band 3) and 2600 MHz (LTE band 7). The prototype achieves an impressive 6.0-7.4-dB noise figure in the presence of a +27-dBm LTE uplink Tx blocker for duplex separations of 47.5 MHz and above. The duplexer has also been tested against reference sensitivity test cases defined in the 3GPP LTE specification, demonstrating specification compliant sensitivity in LTE bands 28 (700 MHz), 3, and 7.
(−)-Epicatechin Activation of Endothelial Cell Endothelial Nitric Oxide Synthase, Nitric Oxide, and Related Signaling Pathways (2010)

Recent reports indicate that (-)-epicatechin can exert cardioprotective actions, which may involve endothelial nitric oxide synthase (eNOS)-mediated nitric oxide production in endothelial cells. However, the mechanism by which (-)-epicatechin activates eNOS remains unclear. In this study, we proposed to identify the intracellular pathways involved in (-)-epicatechin-induced effects on eNOS, using human coronary artery endothelial cells in culture. Treatment of cells with (-)-epicatechin led to time- and dose-dependent effects that peaked at 10 minutes at 1 mumol/L. (-)-Epicatechin treatment activates eNOS via serine 633 and serine 1177 phosphorylation and threonine 495 dephosphorylation. Using specific inhibitors, we have established the participation of the phosphatidylinositol 3-kinase pathway in eNOS activation. (-)-Epicatechin induces eNOS uncoupling from caveolin-1 and its association with calmodulin-1, suggesting the involvement of intracellular calcium. These results allowed us to propose that (-)-epicatechin effects may be dependent on actions exerted at the cell membrane level. To test this hypothesis, cells were treated with the phospholipase C inhibitor U73122, which blocked (-)-epicatechin-induced eNOS activation. We also demonstrated inositol phosphate accumulation in (-)-epicatechin-treated cells. The inhibitory effects of the preincubation of cells with the calmodulin-dependent kinase II (CaMKII) inhibitor KN-93 indicate that (-)-epicatechin-induced eNOS activation is at least partially mediated via the Ca(2+)/CaMKII pathway. The (-)-epicatechin stereoisomer catechin was only partially able to stimulate nitric oxide production in cells. Together, these results strongly suggest the presence of a cell surface acceptor-effector for the cacao flavanol (-)-epicatechin, which may mediate its cardiovascular effects.
Fair Scheduling with Multiple Gateways in Wireless Mesh Networks (2009)

This paper addresses the problem of scheduling in Wireless Mesh Networks (WMNs). The paper first discusses existing scheduling algorithms and classifies them based on the technique they use and their implementation frameworks.Then detailed discussions of the proposed scheduling method are presented. Simulation experiments are conducted to compare the performance of fair scheduling with the method that does not use fair scheduling. The simulation results confirm that the proposed scheduling method has better performance with respect to the metrics used for performance evaluation.
A human HAP1 homologue. Cloning, expression, and interaction with Huntingtin. (1999)

The following acknowledgment was inadvertently omitted. Cloning of human HAP1 was initiated in the laboratory of Dr. Christopher Ross at The Johns Hopkins University, and the initial cloning work was supported by NINDS National Institutes of Health Grant NS 16375 and the DeVelbiss Fund.
Metal-Free Multicomponent Syntheses of Pyridines (2014)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTMetal-Free Multicomponent Syntheses of PyridinesChristophe Allais, Jean-Marie Grassot, Jean Rodriguez*, and Thierry Constantieux*View Author Information Aix Marseille Université, Centrale Marseille, CNRS, iSm2 UMR 7313, 13397 MARSEILLE, France*E-mail: [email protected]*E-mail: [email protected]Cite this: Chem. Rev. 2014, 114, 21, 10829–10868Publication Date (Web):October 10, 2014Publication History Received19 February 2014Published online10 October 2014Published inissue 12 November 2014https://pubs.acs.org/doi/10.1021/cr500099bhttps://doi.org/10.1021/cr500099breview-articleACS PublicationsCopyright © 2014 American Chemical SocietyRequest reuse permissionsArticle Views9483Altmetric-Citations417LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aldehydes,Aromatic compounds,Cations,Pyridines,Reaction products Get e-Alerts
Use of Bromodeoxyuridine, Proliferating Cell Nuclear Antigen, and Nucleolar Organizer Regions in the Multiparametric Assessment of Proliferating Potency in Cervical Intraepithelial Neoplasia (1995)

The authors analysed of the proliferative activity of intraepithelial neoplasia of the cervix utilizing the labeling index of monoclonal antibody to Bromodeoxyuridine (BrdU) or proliferating cell nuclear antigen (PCNA), and the number of Nucleolar organizer regions (Ag-NOR). The BrdU labeling index (B.L.I.) for normal squamous epithelium, mild dysplasia, and moderate dysplasia were significantly lower than for severe dysplasia or carcinoma in situ. The PCNA labeling index (P.L.I.) for normal squamous epithelium, mild dysplasia, and moderate dysplasia were significantly lower than for severe dysplasia or carcinoma in situ. The number of Ag-NOR dots of normal squamous epithelium and mild dysplasia were lower than those of severe dysplasia or carcinoma in situ. There are significantly positive correlations of the B.L.I., P.L.I., and the number of Ag-NORs in cervical intraepithelial neoplasia.
Towards Visually Explaining Similarity Models (2020)

We consider the problem of visually explaining similarity models, i.e., explaining why a model predicts two images to be similar in addition to producing a scalar score. While much recent work in visual model interpretability has focused on gradient-based attention, these methods rely on a classification module to generate visual explanations. Consequently, they cannot readily explain other kinds of models that do not use or need classification-like loss functions (e.g., similarity models trained with a metric learning loss). In this work, we bridge this crucial gap, presenting a method to generate gradient-based visual attention for image similarity predictors. By relying solely on the learned feature embedding, we show that our approach can be applied to any kind of CNN-based similarity architecture, an important step towards generic visual explainability. We show that our resulting attention maps serve more than just interpretability; they can be infused into the model learning process itself with new trainable constraints. We show that the resulting similarity models perform, and can be visually explained, better than the corresponding baseline models trained without these constraints. We demonstrate our approach using extensive experiments on three different kinds of tasks: generic image retrieval, person re-identification, and low-shot semantic segmentation.
Determination of Gamma-hydroxybutyrate in Water and Human Urine by Solid Phase Microextraction-Gas Chromatography/Quadrupole Ion Trap Spectrometry (2001)

A simple method of detection was developed for gamma-hydroxybutyrate (GHB). The method involves the derivatization of GHB using a hexyl-chloroformate procedure in aqueous media (such as water or urine), extraction of the derivatization product directly from the sample using solid-phase microextraction, and subsequent separation and detection with gas chromatography quadrupole ion trap mass spectrometry. The deuterated form of GHB (GHB-D6) is used as an internal standard for quantitation. The method was linear for GHB-spiked pure water samples from 2 to 150 microg/mL GHB with a detection limit of 0.2 microg/mL. Spiked urine samples showed linearity from 5 to 500 microg/mL GHB with a detection limit of 2 microg/mL. The SPME-GC/MS method is applied to actual case samples, and the results are compared to those values obtained using a conventional GC/MS method. Sensitivity and linearity are comparable to those seen using traditional methods of separation, yet the SPME method is superior due to the simplicity, speed of analysis, reduction in solvent waste, and ability to differentiate between GHB and gamma-butyrolactone (GBL).
The Design of Tetrode Transistor Amplifiers (1956)

The design of tetrode transistor amplifiers encounters problems of the type that occurs with other transistor uses. Desired frequency characteristics, limitations of parasitic elements, and other practical considerations impose constraints on the range of terminations that can be employed. With many transistors, one can terminate a transistor so that it will oscillate without external feedback; this oscillation or other exceedingly sensitive terminations must be avoided. The two-port parameters of the transistor in any orientation in which it is to be used constitute the fixed or given information which is the starting point of the amplifier design. Using this starting point, methods are developed by which one can select, on simple bases, the kinds of terminations that will be suitable. To facilitate the design of amplifiers, a set of charts has been developed from which one can read power gain and input impedance as functions of the load termination. Illustrative tetrode amplifiers are described. These include a common base 20-mc video amplifier, a common-emitter 10-mc video amplifier, an IF amplifier centered at 30 mc, and an IF amplifier centered at 70 mc. Predicted and measured gains are compared.
An Extension of a Theorem of G. Szego and Its Application to the Study of Stochastic Processes (1954)

Ulf Grenander, Murray Rosenblatt, An Extension of a Theorem of G. Szego and Its Application to the Study of Stochastic Processes, Transactions of the American Mathematical Society, Vol. 76, No. 1 (Jan., 1954), pp. 112-126
Blue Emissive fac/mer‐Iridium (III) NHC Carbene Complexes and their Application in OLEDs (2021)

Abstract The photophysical and electrochemical properties of N‐heterocyclic carbene complexes of Iridium (III) (Ir(C ^ C:) 3 , where C ^ C: = N‐phenyl,N‐methyl‐pyrazinoimidazol‐2‐yl (pmpz), N,N‐di‐p‐tolyl‐pyrazinoimidazol‐2‐yl (tpz)) are reported. Facial and meridional isomers of Ir(pmpz) 3 are prepared, but only the facial isomer can be isolated for Ir(tpz) 3 . The fac ‐Ir(pmpz) 3 and fac ‐Ir(tpz) 3 complexes have emission maxima at 465 nm in polystyrene, whereas the emission maximum of mer ‐Ir(pmpz) 3 is redshifted to 495 nm. The emission energies and photoluminescent quantum yield (Φ PL ) in solution decrease on going from nonpolar to polar solvents; however, all the complexes are efficient emitters in polystyrene at room temperature (Φ PL = 88–96%) and 77 K. Blue phosphorescent organic light emitting diodes employing fac ‐Ir(tpz) 3 as an emissive dopant achieves a high external electroluminescence efficiency (≈18 ± 1%) and brightness (29 000 cd m −2 ) at low current density.
The Fe–S proteome of Escherichia coli: prediction, function, and fate (2022)

Iron-sulfur (Fe-S) clusters are inorganic ubiquitous and ancient cofactors. Fe-S-bound proteins contribute to most cellular processes, including DNA replication and integrity, genetic expression and regulation, metabolism, biosynthesis, and most bioenergetics systems. Also, Fe-S proteins hold a great biotechnological potential in metabolite and chemical production, including antibiotics. From classic biophysics and spectroscopy methodologies to recent development in bioinformatics, including structural modeling and chemoproteomics, our capacity to predict and identify Fe-S proteins has spectacularly increased over the recent years. Here, these developments are presented and collectively used to update the composition of Escherichia coli Fe-S proteome, for which we predict 181 occurrences, i.e. 40 more candidates than in our last catalog, and equivalent to 4% of its total proteome. Besides, Fe-S clusters can be targeted by redox active compounds or reactive oxygen and nitrosative species, and even be destabilized by contaminant metals. Accordingly, we discuss how cells handle damaged Fe-S proteins, i.e. degradation, recycling, or repair.
All-Optical Electrochemiluminescence (2023)

Electrochemiluminescence (ECL) is widely employed for medical diagnosis and imaging. Despite its remarkable analytical performances, the technique remains intrinsically limited by the essential need for an external power supply and electrical wires for electrode connections. Here, we report an electrically autonomous solution leading to a paradigm change by designing a fully integrated all-optical wireless monolithic photoelectrochemical device based on a nanostructured Si photovoltaic junction modified with catalytic coatings. Under illumination with light ranging from visible to near-infrared, photogenerated holes induce the oxidation of the ECL reagents and thus the emission of visible ECL photons. The blue ECL emission is easily viewed with naked eyes and recorded with a smartphone. A new light emission scheme is thus introduced where the ECL emission energy (2.82 eV) is higher than the excitation energy (1.18 eV) via an intermediate electrochemical process. In addition, the mapping of the photoelectrochemical activity by optical microscopy reveals the minority carrier interfacial transfer mechanism at the nanoscale. This breakthrough provides an all-optical strategy for generalizing ECL without the need for electrochemical setups, electrodes, wiring constraints, and specific electrochemical knowledge. This simplest ECL configuration reported so far opens new opportunities to develop imaging and wireless bioanalytical systems such as portable point-of-care sensing devices.
Lewis Acid Catalyzed Intramolecular Allylic Substitution of Bis(trichloroacetimidates): A Versatile Approach to Racemic Unsaturated Amino Acids (2011)

Lewis acid catalyzed cyclization of trichloroacetimidates derived from 1,4-butenediols and 1,5-butenediols was achieved to give 4-vinyl oxazolines and 4-vinyloxazines in good to excellent yields. The cyclization products were transformed to protected unsaturated α- and β-amino acids, thus demonstrating the novel approach to access these important classes of compounds.
Being Thrifty on a $100K Wage (2015)

Understanding how families manage their finances represents a highly important research agenda given the recent economic climate of debt and uncertainty. To have a better understanding of the economics in domestic settings, it is very important to study the ways money and financial issues are collaboratively handled within families. Using an ethnographic approach, we studied the everyday financial practices of fifteen middle-income families. Our preliminary results show that there is a strong tendency to live frugally; that, people apply various and creative mechanisms to minimize their expenses and save money seemingly irrespectively of their income. To this end we highlight some implications for designing technologies to support household financial practices.
A base station adaptive antenna for downlink transmission in a DS-CDMA system (2002)

Multi-rate services are flexibly available by a DS-CDMA technique. Since high-bit rate signals have high transmitted power, they cause large multiple access interference (MAI) to low-bit rate users. A base station adaptive antenna has been studied to suppress the large MAI from the high-speed users. In an uplink case, the adaptive antenna for the low-speed user needs to reduce the received power of the high-speed signals. This is carried out by forming nulls toward the high-bit rate users. In the downlink case, however, the adaptive antenna for the high-speed user needs to reduce the transmitted power toward many low-bit rate users. If there are many low-speed users, we have a shortage of the freedom of the array pattern. That is, the interference to the low-bit rate users cannot be rejected. We propose a novel adaptive array structure to reduce the interference for many user environment.
“No Coding” of Glucose Test Strips: A Roche Perspective (2008)

We eliminated the handling step of coding and retained all the advantages of coding. In Roche's newest all-in-one glucose meter, the ACCU-CHEK Compact Plus system, the batch-specific code is integrated into the drum that contains the glucose test strips. As a result, changing the drum containing the glucose test strips automatically changes the glucose test strip code. Patients with diabetes who use the ACCU-CHEK Compact Plus glucose meter do not have to be concerned with coding.
ISS: The Interactive Smart home Simulator (2009)

Digital homes provide the best services to home's occupants by using modern devices, home appliances that integrate transparently and simplify usability in the home. However, the realization in the real environment is difficult and takes a long time from building the scratch. Thus, to support the implementation in the real smart home, it is necessary to demonstrate that thing can be done in the simulator which deals with virtual appliances and devices models the real smart home environment. In this paper, we propose ISS, an Interactive Smart home Simulator system focusing on controlling and simulating the behavior of an intelligent house. The developed system aims to provide architects, designers a simulation and useful tool for understanding the interaction between environment, people and the impact of embedded and pervasive technology on in daily life. In this research, the smart house is considered as an environment made up of independent and distributed devices interacting to support user's goals and tasks. Therefore, by using ISS, the developer can realize the relationship among virtual home space, surrounded environment, users and home appliances.