gebhart/patrepeval huggingface dataset:
Multimodal nanoscale imaging of chromatin with super resolution microscopy and partial wave spectroscopy (Conference Presentation) (2018)

We demonstrate a multimodal imaging methodology to probe the nanoscale environment of cells. The system combines partial-wave spectroscopic (PWS) microscopy and spectroscopic photon localization microscopy (SPLM). PWS quantifies the nanoarchitecture of cells with sensitivity to structures between 20 and 200 nm. SPLM is a newly developed super-resolution imaging technique based upon the principles of single-molecule localization microscopy and spectroscopy. In addition to allowing super-resolution imaging, SPLM provides inherent molecular-specific spectroscopic information of targeted structures visualized when dyes are used. Combining both of these modalities into a single instrument allows nanoscale characterization of the super-resolution molecular imaging provided by SPLM as it relates to nanoscale structural information provided by PWS. As an example, we labeled RNA polymerase in HeLa cells and showed correlations between the locations of the RNA polymerase visualized by SPLM and the nanoscale structure of the chromatin measured by PWS. Such information is crucial in understanding the role of specific molecules in regulating the chromatin structure and gene expression. More broadly, this instrument can give insight into the molecular pathways of diseases and therapeutic treatments of those diseases, while simultaneously showing the effects on chromatin topology.
The TOPSAR interferometric radar topographic mapping instrument (1992)

The authors have augmented the NASA DC-8 AIRSAR instrument with a pair of C-band antennas displaced across track to form an interferometer sensitive to topographic variations of the Earth's surface. During the 1991 DC-8 flight campaign, data were acquired over several sites in the US and Europe, and topographic maps were produced from several of these flight lines. Analysis of the results indicate that statistical errors are in the 2-4-m range, while systematic effects due to aircraft motion are in the 10-20-m range. The initial results from development of a second-generation processor show that aircraft motion compensation algorithms reduce the systematic variations to 2 m, while the statistical errors are reduced to 2-3 m.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Scientific Opinion on the safety assessment of the process “MKF‐Ergis”, used to recycle post‐consumer PET into food contact materials (2014)

International audience
CHARGE SCREENING IN THE FINITE TEMPERATURE SCHWINGER MODEL (1996)

We compute the effective action and correlators of the Polyakov loop operator in the Schwinger model at finite temperature and discuss the realization of the discrete symmetries that occur there. We show that, due to nonlocal effects of massless fermions in two space–time dimensions, the discrete symmetry which governs the screening of charges is spontaneously broken even in an effective one-dimensional model, when the volume is infinite. In this limit, the thermal state of the Schwinger model screens an arbitrary external charge; consequently the model is in the deconfined phase, with the charge of the deconfined fermions completely screened. In a finite volume we show that the Schwinger model is always confining.
Effect of Sodium Dodecyl Sulfate on Surface Roughness and Nucleation Mechanisms of Electrodeposited CuInSe2Films (2012)

In this study, the p-type CuInSe2 thin films were fabricated by using pulse electrodeposition with anionic surfactant sodium dodecyl sulfate (SDS) as an additive. The effect of the SDS on the surface roughness and the nucleation mechanisms of electrodeposited CuInSe2 films have been investigated in detail. It was found that films fabricated in electrolyte containing SDS surfactant are smooth and compact compared to those fabricated in electrolyte without the SDS surfactant. AFM images show that the self-assembly of SDS molecules can form directional and oblique lines lying on the Mo surface. These oblique lines can form a monolayer to change the nucleation mechanisms of films from the instantaneous to the progressive mode. The vibration modes of the chalcopyrite structure and the identification of CuxSe secondary phases were examined by micro-Raman spectrometry, which showed a decrease in secondary phases when SDS concentration was increased from 0.3 mM to 5 mM.
Automated generation of intent-based 3D Illustrations (1991)

This paper describes an automated intent-based approach to illustration. An illustrution is a picture that is designed to fulfill a communicative intent such as showing the location of an object or showing how an object is manipulated. An illustration is generated by implementing a set of stylistic decisions, ranging from determining the way in which an individual object is lit, to deciding the general composition of the illustration. The design of an illustration is treated as a goal-driven process within a system of constraints. The goal is to achieve communicative intent; the constraints are the illustrative techniques an illustrator can apply.We have developed IBIS (Intent-Based Illustration System), a system that puts these ideas into practice. IBIS designs illustrations using a generate-and-test approach, relying upon a rule-based system of methods and evaluators. Methods are rules that specify how to accomplish visual effects, while evaluators are rules that specify how to determine how well a visual effect is accomplished in an illustration. Examples of illustrations designed by IBIS are included.
Effect of Unsteady Stator Wake—Rotor Double-Leakage Tip Clearance Flow Interaction on Time-Average Compressor Performance (2003)

A study has been conducted, using unsteady three-dimensional Reynolds-averaged Navier-Stokes simulations to determine the impact on rotor performance of the interaction between upstream (steady defect and time-varying defect) stator wakes and rotor tip clearance flow. The key effects of the interaction between steady stator wakes and rotor tip clearance flow are: 1) a decrease in loss and blockage associated with tip clearance flow; 2) an increase in passage static pressure rise. Performance benefit is seen in the operability range from near design to high loading. The benefit is modest near design and increases with loading. Significant beneficial changes due to the stator-rotor interaction occur when the phenomenon of tip clearance flow double-leakage is present. Double-leakage occurs when the tip clearance flow passes through the tip gap of the adjacent blade. It is detrimental for compressor performance. The effect of strong stator-rotor interaction is to suppress double-leakage on a time-average basis. Double-leakage typically takes place at high loading but can be present at design condition as well, for modern highly loaded compressor. A benefit due to unsteady interaction is also observed in the operability range of the rotor. A new generic causal mechanism is proposed to explain the observed changes in performance. It identifies the interaction between the tip clearance flow and the pressure pulses, induced on the rotor blade pressure surface by the upstream wakes, as the cause for the observed effects. The direct effect of the interaction is a decrease in the time-average double-leakage flow through the tip clearance gap so that the stream-wise defect of the exiting tip flow is lower with respect to the main flow. A lower defect leads to a decrease in loss and blockage generation and hence an enhanced performance compared to that in the steady situation. The performance benefits increase monotonically with loading and scale linearly with upstream wake velocity defect. With oscillating defect stator wakes, rotor performance shows dependence on oscillation frequency. Changes in the tip region occur at a particular reduced frequency leading to (1) decrease in blockage, and (2) increase in passage loss. The changes in rotor performance at a particular reduced frequency are hypothesized to be associated with the inherent unsteadiness of the tip clearance vortex and its resonance behavior excited by the oscillating wakes.
Morphological Change of Fibroblast Cells on Titanium and Platinum Cultured at Anodic and Cathodic Potentials (2008)

To understand cellular response against applied potential on different electrode materials, cell morphology and cell coverage of murine fibroblast L929 cultured on Ti and Pt electrodes were examined. Anodic and cathodic potentials were applied on Ti and Pt using a potentiostat. At the anodic potentials of 800 and 950 mV vs. Ag/AgCl, no cells kept a normal shape on both Ti and Pt. At the cathodic potential of −350 mV, the cells on Ti were normally extended ; whereas some of the cells on Pt were aggregated or round. At −1000 mV, the cells had spherical shape on Ti, while the Pt surface was covered by white precipitates with no cell remained. The change in cell morphology and the decrease in coverage at anodic potentials were significantly larger than those at the cathodic potentials. The morphological change of L929 on Ti was rather smaller than that on Pt at the same potentials, which is probably because the electric filed around the cells on Ti is smaller than that on Pt owing to the surface oxide film on Ti. These facts indicate that the cell response to the applied potential depends on the azimuth of electric field and electrode materials.
End-to-end disaster recovery planning: From art to science (2010)

We present the design and implementation of ENDEAVOUR - a framework for integrated end-to-end disaster recovery (DR) planning. Unlike existing research that provides DR planning within a single layer of the IT stack (e.g. storage controller based replication), ENDEAVOUR can choose technologies and composition of technologies across multiple layers like virtual machines, databases and storage controllers. ENDEAVOUR uses a canonical model of available replication technologies at all layers, explores strategies to compose them, and performs a novel map-search-reduce heuristic to identify the best DR plans for given administrator requirements. We present a detailed analysis of ENDEAVOUR including empirical characterization of various DR technologies, their composition, and a end-to-end case study.
Data from Imaging Breast Cancer Chemotherapy Response with Light (2023)

&lt;div&gt;Abstract&lt;p&gt;Diffuse optical spectroscopy (DOS), which is used to image tumor metabolic response to neoadjuvant chemotherapy (NAC), shows large changes in tumor functional parameters with significant reductions in oxy- and deoxyhemoglobin for responders versus nonresponders. Although investigational, DOS may provide a cost-effective, risk-free method for optimizing NAC drug and dosing strategies for individual patients. Clin Cancer Res; 16(9); 2486–8. ©2010 AACR.&lt;/p&gt;&lt;/div&gt;
Development of an autonomous bridge deck inspection robotic system (2017)

Abstract The threat to safety of aging bridges has been recognized as a critical concern to the general public due to the poor condition of many bridges in the United States. Currently, the bridge inspection is conducted manually, and it is not efficient to identify bridge condition deterioration in order to facilitate implementation of appropriate maintenance or rehabilitation procedures. In this paper, we report a new development of the autonomous mobile robotic system for bridge deck inspection and evaluation. The robot is integrated with several nondestructive evaluation (NDE) sensors and a navigation control algorithm to allow it to accurately and autonomously maneuver on the bridge deck to collect visual images and conduct NDE measurements. The developed robotic system can reduce the cost and time of the bridge deck data collection and inspection. For efficient bridge deck monitoring, the crack detection algorithm to build the deck crack map is presented in detail. The impact‐echo (IE), ultrasonic surface waves (USW), and electrical resistivity (ER) data collected by the robot are analyzed to generate the delamination, concrete elastic modulus, corrosion maps of the bridge deck, respectively. The presented robotic system has been successfully deployed to inspect numerous bridges in more than ten different states in the United States.
Promoter hijack reveals pericentrin functions in mitosis and the DNA damage response (2013)

Centrosomes, the principal microtubule-organizing centers of animal somatic cells, consist of two centrioles embedded in the pericentriolar material (PCM). Pericentrin is a large PCM protein that is required for normal PCM assembly. Mutations in PCNT cause primordial dwarfism. Pericentrin has also been implicated in the control of DNA damage responses. To test how pericentrin is involved in cell cycle control after genotoxic stress, we disrupted the Pcnt locus in chicken DT40 cells. Pericentrin-deficient cells proceeded through mitosis more slowly, with a high level of monopolar spindles, and were more sensitive to spindle poisons than controls. Centriole structures appeared normal by light and electron microscopy, but the PCM did not recruit γ-tubulin efficiently. Cell cycle delays after ionizing radiation (IR) treatment were normal in pericentrin-deficient cells. However, pericentrin disruption in Mcph1-/- cells abrogated centrosome hyperamplification after IR. We conclude that pericentrin controls genomic stability by both ensuring appropriate mitotic spindle activity and centrosome regulation.
Transmigration of CD34+ Cells Across Specialized and Nonspecialized Endothelium Requires Prior Activation by Growth Factors and Is Mediated by PECAM-1 (CD31) (1998)

The transmigration of hematopoietic progenitor cells (HPCs) across vascular endothelium is a critical step in the homing of transplanted stem cells, but the molecular basis for this is unknown. We used mobilized peripheral blood CD34(+) selected cells and cultured bone marrow microvascular (BMECs) and human umbilical vein endothelial cells (HUVECs) to investigate the adhesion and transendothelial migration of HPCs. Colony-forming cells (CFCs) in freshly isolated CD34(+) cells showed high levels of adhesion to both forms of endothelium (28% +/- 4% and 38% +/- 6% of granulocyte-macrophage colony-forming cells [GM-CFCs] adhering to HUVECs and BMECs, respectively), but were unable to migrate to any significant extent across either (1.0% +/- 0.3% and 1.1% +/- 0.6% of GM-CFCs migrating across HUVECs and BMECs, respectively). Greater than 95% of peripheral blood CD34(+) cells are in G0/G1 of the cell cycle, but after 48 to 72 hours of stimulation with growth factors (interleukin-3 [IL-3] 12 ng/mL, stem cell factor 10 ng/mL, and IL-6 10 ng/mL), 28% +/- 5% of cells were in S+G2/M. Growth factor stimulation had no effect on the adhesion of mobilized CFCs but resulted in enhanced migration of these cells (9.8% +/- 1.6% and 12. 6% +/- 3.1% of GM-CFCs migrating across HUVECs and BMECs, respectively; P < .01, n = 6). Assessment of cell proliferation by the 3H-thymidine suicide method showed that, whereas 11.7% +/- 3.3% of proliferating CFCs transmigrated across endothelium, only 1.3% +/- 0.3% of nonproliferating CFCs did so (P < .05, n = 5). Transmigration of growth factor-activated CFCs was inhibited by anti-CD18 monoclonal antibody (MoAb; 50% +/- 18% inhibition) and by anti-platelet endothelial cell adhesion molecule-1 (PECAM-1) MoAb (70.8% +/- 7.1% inhibition; P < .05, n = 3). IL-1 stimulation of HUVECs had no significant effect on CD34(+) cell transmigration, but caused marked enhancement of neutrophil migration. Stem cell homing may depend, in part, on the ability of local cytokines to upregulate the transmigratory ability of these cells. The transmigration of HPCs shares at least some molecular pathways with that of mature cells (CD18 and PECAM-1), but is differently affected by endothelial activation.
The chemistry of Stemona alkaloids: An update (2010)

Covering: 1999 to August 2009. Previous review: Nat. Prod. Rep., 2000, 17, 117
2-Tetrahydropyridylindoles as histamine and serotonin antagonists (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-Tetrahydropyridylindoles as histamine and serotonin antagonistsRobert N. Schut, Frederick E. Ward, O. J. Lorenzetti, and Enrique HongCite this: J. Med. Chem. 1970, 13, 3, 394–397Publication Date (Print):May 1, 1970Publication History Published online1 May 2002Published inissue 1 May 1970https://pubs.acs.org/doi/10.1021/jm00297a014https://doi.org/10.1021/jm00297a014research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mercury-Neon Tube (1964)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Alan J. Bearden; Mercury-Neon Tube. Am. J. Phys. 1 March 1964; 32 (3): xx. https://doi.org/10.1119/1.1970231 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAmerican Association of Physics TeachersAmerican Journal of Physics Search Advanced Search |Citation Search
Spatiotemporal representation of long-delayed systems: An alternative approach (2020)

Dynamical systems with long-delay feedback can exhibit complicated temporal phenomena, which once reorganized in a two-dimensional space are reminiscent of spatiotemporal behavior. In this framework, a normal forms description has been developed to reproduce the dynamics, and the opportunity to treat the corresponding variables as true space and time has since been established. However, recently, an alternative approach has been proposed [F. Marino and G. Giacomelli, Phys. Rev. E 98, 060201(R) (2018)2470-004510.1103/PhysRevE.98.060201] with a different interpretation of the variables involved, which better takes into account their physical character and allows for an easier determination of the normal forms. In this paper, we extend such idea and apply it to a number of paradigmatic examples, paving the way to a rethinking of the concept of spatiotemporal representation of long-delayed systems.
Forced oscillation technique to assess exercise and post-exercise bronchodilator responses in preterm-born children (2018)

<b>Introduction:</b> Forced oscillation technique (FOT) is a useful tool for measuring airway mechanics in children. We assessed FOT before/after exercise and after post-exercise bronchodilator therapy in preterm-born children. <b>Methods:</b> From 70 children, mean age 11.6 years, recruited in our on-going RHiNO (Respiratory Health Outcomes in Neonates) study, 13 (PT<sub>low</sub>) and 39 (PT<sub>C</sub>) preterm-born children of ≤34 weeks’ gestation were classified according to their predicted %FEV<sub>1</sub> of ≤85% or &gt;85% respectively; and 18 (T<sub>C</sub>) were term-born. FOT was performed at baseline, after maximal exercise and after post-exercise salbutamol. <b>Results:</b> Baseline resistance averaged across 6-32Hz (Rrs<sub>6-32</sub>), at 6Hz (Rrs<sub>6</sub>) and at 20Hz (Rrs<sub>20</sub>), were greater in the PT<sub>low</sub> group compared to T<sub>C</sub> (Rrs<sub>6-32</sub> 5.8 vs 4.6 hPa.s/L; Rrs<sub>6</sub> 6.7 vs 4.7 hPa.s/L, Rrs<sub>20</sub> 5.6 vs 4.5 hPa.s/L, although not statistically different at Rrs<sub>20</sub>). Lower (more negative) reactance (Xrs) at 6 and 20Hz, and lower compliance (C), were noted in the PT<sub>low</sub> group compared to the two control groups (Xrs<sub>6</sub> -3.4 vs -1.8 vs -1.7 hPa.s/L; Xrs<sub>20</sub> -1 vs -0.2 vs 0 hPa.s/L; C 7.8 vs 12.7 vs 13.5 ml/hPa). Exercise did not have an appreciable effect on impedance. Following bronchodilators, all parameters essentially improved in all groups with the greatest improvements observed in the PT<sub>low</sub> group, although not all differences reached statistical significance. <b>Conclusions:</b> Exercise appeared not to impact on FOT-assessed airway mechanics in preterm children; however, post-exercise bronchodilators improved resistance and reactance in preterm subjects.
Partial Deficiency of Muscle Carnitine Palmitoyltransferase with Normal Ketone Production (1978)

RECURRENT rhabdomyolysis is a feature of conditions in which skeletal-muscle metabolism of carbohydrates is defective, as in deficiency of muscle phosphorylase1 , 2 and phosphofructokinase.3 In addition, two patients have been described in whom recurrent myoglobinuria resulted from an impairment in fat oxidation due to a deficiency of carnitine palmitoyltransferase in skeletal muscle.4 These patients also demonstrated diminished ketone production in spite of high levels of plasma free fatty acids and increasing plasma triglyceride levels during prolonged fasting, suggesting a deficiency of carnitine palmitoyltransferase in the liver.4 We report below the clinical and biochemical findings in a patient with recurrent myoglobinuria and . . .
Type 2 diabetes mellitus worsens neurological injury following cardiac arrest: an animal experimental study (2018)

In a cardiac arrest model, neuronal injury is increased in type 2 diabetes mellitus animals compared with non-diabetic controls. Although this study lacks to uncover the specific mechanisms causing increased neuronal injury, the establishment of a cardiac arrest model of type 2 diabetes mellitus lays the important foundation for further experimental investigations within this field.
Convolution algorithm for the Lorentz function (1979)

An algorithm for the accelerated convolution of the Lorentz function with spectral line data has been developed. The method involves the decomposition of the Lorentz function into subfunctions spanning finite domains. The subfunctions are convolved independently with line data at appropriate sampling intervals. The spectral absorption is obtained by superposition of the independent convolutions. A criterion for the specification of the sampling interval is described.
Iron‐Catalyzed Mild and Selective Hydrogenative Cross‐Coupling of Nitriles and Amines To Form Secondary Aldimines (2017)

Abstract The first example of a base‐metal‐catalyzed homogeneous hydrogenative coupling of nitriles and amines to selectively form secondary cross‐imines is reported. The reaction is catalyzed under mild conditions by a well‐defined (iPr‐PNP)Fe(H)Br(CO) pincer pre‐catalyst and catalytic t BuOK.