gebhart/patrepeval huggingface dataset:
Nerve‐Sparing Gynecologic Surgery Enabled by A Near‐Infrared Nerve‐Specific Fluorophore Using Existing Clinical Fluorescence Imaging Systems (2023)

Patients undergoing gynecological procedures suffer from lasting side effects due to intraoperative nerve damage. Small, delicate nerves with complex and nonuniform branching patterns in the female pelvic neuroanatomy make nerve-sparing efforts during standard gynecological procedures such as hysterectomy, cystectomy, and colorectal cancer resection difficult, and thus many patients are left with incontinence and sexual dysfunction. Herein, a near-infrared (NIR) fluorescent nerve-specific contrast agent, LGW08-35, that is spectrally compatible with clinical fluorescence guided surgery (FGS) systems is formulated and characterized for rapid implementation for nerve-sparing gynecologic surgeries. The toxicology, pharmacokinetics (PK), and pharmacodynamics (PD) of micelle formulated LGW08-35 are examined, enabling the determination of the optimal imaging doses and time points, blood and tissue uptake parameters, and maximum tolerated dose (MTD). Application of the formulated fluorophore to imaging of female rat and swine pelvic neuroanatomy validates the continued clinical translation and use for real-time identification of important nerves such as the femoral, sciatic, lumbar, iliac, and hypogastric nerves. Further development of LGW08-35 for clinical use will unlock a valuable tool for surgeons in direct visualization of important nerves and contribute to the ongoing characterization of the female pelvic neuroanatomy to eliminate the debilitating side effects of nerve damage during gynecological procedures.
Rhabdomyolysis and HMG-CoA Reductase Inhibitors (2001)

Rhabdomyolysis is a rare but clinically important adverse event of statin monotherapy or combination therapy. Thorough understanding of this condition may help prevent or minimize adverse health outcomes in patents receiving statin therapy.
Prediction of Malingant Plasma Cell Biology Related Survival in AL-Amyloidosis (2019)

Background. Survival in AL-amyloidosis is thought to be primarily determined by signs and symptoms caused by deposition of amyloid light chains, most prominently in the heart. In contrast, molecular characteristics of the underlying malignant plasma cell disease have been described, but are mostly considered less important. Aim of our study is to predict malignant plasma cell biology related survival in AL-amyloidosis by establishing the first gene expression based risk stratification (HDAL) and assessing its independence from clinical serum parameter assessing risk. Methods. CD138+-purified plasma cell samples of 919 patients with malignant plasma cell diseases, i.e. 195 AL-amyloidosis and 724 symptomatic myeloma patients were investigated by gene expression profiling, 124 AL-amyloidosis patients by RNA-sequencing. Gene expression profiling data of AL-amyloidosis patients were spitted in a training (TG, n=99) and a validation group (VG, n=96). A two-step model according to Rème et al. was applied on the training group, including a running log rank test for gene selection and a multi-cut-off running log-rank algorithm for optimal cut-off-selection, leading to a selection of 15 genes associated with good and 44 genes with adverse prognosis. The resulting HDAL-score was validated on the independent VG and our myeloma patient cohort using survival estimates for censored data. Differences between curves were assessed using the Log-rank test. The continuous RNA-Seq HDAL-score (R-HDAL) was subsequently derived to validate the survival association of the selected genes. HDAL was tested for independence with serum parameter assessing clinical staging systems by multivariate Cox regression. Results. Categorical split of the HDAL-score delineates three significantly predictive groups of 48%, 29% and 23% of AL-amyloidosis patients with a median survival of 105, 53 and 3 months in the training, and 72, 33 and 6 months in the validation group, respectively. In symptomatic myeloma patients, HDAL significantly stratifies two groups with a median survival of 128 and 78 months. Thus, HDAL is a malignant plasma biology related derived risk stratification. HDAL and R-HDAL are significantly predictive for survival as continuous parameters. Categorial and continuous HDAL are individually independent predictive from clinical staging systems, i.e. Mayo 2004, 2012 and Euro score, and the assessed serum parameters, i.e. NT-ProBNP, cTNT and dFLC. In conclusion, malignant plasma cell biology related and amyloid deposition mediated survivals in AL-amyloidosis are independent. Prognosis driven by the first component can significantly be assessed by transcriptome profiling (HDAL or R-HDAL). We thank U. Hegenbart and S. Schönland for clinical collaboration in this work. Disclosures Moreaux: Diag2Tec: Other: Co-founder of Diag2Tec company.
Growth of Azolla with Rice and Its Effect on Rice Yield (1981)

This article 'Growth of Azolla with Rice and Its Effect on Rice Yield' appeared in the International Rice Research Newsletter series, created by the International Rice Research Institute (IRRI). The primary objective of this publication was to expedite communication among scientists concerned with the development of improved technology for rice and for rice based cropping systems. This publication will report what scientists are doing to increase the production of rice in as much as this crop feeds the most densely populated and land scarce nations in the world.
Cover Feature: Interface Engineering of MoS2‐Modified Graphitic Carbon Nitride Nano‐photocatalysts for an Efficient Hydrogen Evolution Reaction (ChemPlusChem 7/2020) (2020)

The Cover Feature shows a 2D/2D nanojunction architecture composed of exfoliated graphitic carbon nitride (g-C3N4) flakes and 2H MoS2 nanosheets. By tuning the lateral dimension of the MoS2 layers, this system possesses a balanced combination of relatively high electronic communication and large number of catalytic MoS2 edge sites at the interfacial heterojunctions, thus enabling highly efficient photocatalytic hydrogen production from water. More information can be found in the Full Paper by G. S. Armatas and co-workers (DOI: 10.1002/cplu.202000096).
Natural Orifice Translumenal Endoscopic Surgery: Myth or Reality? (2009)

Interest in natural orifice translumenal endoscopic surgery (NOTES) has blossomed since the publication of transgastric peritoneoscopy in animals in 2004. Laboratory research has demonstrated the feasibility of natural orifice surgery and provided insight into the technical innovations necessary to advance the field. Today, natural orifice surgery is entering the clinical realm, both in hybrid laparoscopic-endoscopic cases and a few pure natural orifice procedures. Although the promise of "scarless" surgery entices clinicians and the public alike, care must be taken to introduce novel techniques as safely as possible with critical evaluation of outcomes.
Rh‐Complex Supported on Magnetic Nanoparticles as Catalysts for Hydroformylations and Transfer Hydrogenation Reactions (2022)

Abstract Herein, we describe a facile protocol for the phosphine complex of Rh anchored on the ultrasmall magnetic nanoparticles for transfer hydrogenation and hydroformylation reactions. A diphenylphosphino‐ferrocenylethyl amine was conjugated with dopamine hydrochloride to form dop‐Fc, which was then anchored on the surface of magnetic nanoparticles to produce Fe 3 O 4 @dop‐Fc. The prepared materials were complexed with a Rh precursor as a catalytic center. XRD, FTIR, SEM, TEM, and XPS were used to investigate the structure and its reactivity. Rh‐complexes of Fe 3 O 4 @dop‐Fc were used to convert terminal olefin to aldehyde using syngas (CO : H 2 1 : 1) under pressure, obtaining up to 99% selectivity for branched aldehyde. The wide applicability of the Fe 3 O 4 @dop‐Fc−Rh construct was tested for the selective transfer hydrogenations of nitroarene and N ‐heteroarene. Particularly, quinoline was quantitatively hydrogenated to 1,2,3,4‐tetrahydroquinoline(py‐THQ) using tetrahydroxydiboron (THDB). Also, the functional group tolerance in the reduction of nitroarene and styrene was evaluated. The robustness of the catalyst was tested by reusing it for multiple cycles.
Search for continuous gravitational waves from 20 accreting millisecond x-ray pulsars in O3 LIGO data (2022)

Results are presented of searches for continuous gravitational waves from 20 accreting millisecond x-ray pulsars with accurately measured spin frequencies and orbital parameters, using data from the third observing run of the Advanced LIGO and Advanced Virgo detectors. The search algorithm uses a hidden Markov model, where the transition probabilities allow the frequency to wander according to an unbiased random walk, while the $\mathcal{J}$-statistic maximum-likelihood matched filter tracks the binary orbital phase. Three narrow subbands are searched for each target, centered on harmonics of the measured spin frequency. The search yields 16 candidates, consistent with a false alarm probability of 30% per subband and target searched. These candidates, along with one candidate from an additional target-of-opportunity search done for SAX $\mathrm{J}1808.4\ensuremath{-}3658$, which was in outburst during one month of the observing run, cannot be confidently associated with a known noise source. Additional follow-up does not provide convincing evidence that any are a true astrophysical signal. When all candidates are assumed nonastrophysical, upper limits are set on the maximum wave strain detectable at 95% confidence, ${h}_{0}^{95%}$. The strictest constraint is ${h}_{0}^{95%}=4.7\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}26}$ from IGR $\mathrm{J}17062\ensuremath{-}6143$. Constraints on the detectable wave strain from each target lead to constraints on neutron star ellipticity and $r$-mode amplitude, the strictest of which are ${\ensuremath{\epsilon}}^{95%}=3.1\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}7}$ and ${\ensuremath{\alpha}}^{95%}=1.8\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}5}$ respectively. This analysis is the most comprehensive and sensitive search of continuous gravitational waves from accreting millisecond x-ray pulsars to date.
A hybrid watermark for tamper detection in digital images (2003)

A new hybrid image authentication watermark obtained as a combination of a fragile and a robust watermark is presented. The fragile watermark has good localization and security properties but cannot be used to distinguish malicious changes, such as feature adding or removal, from innocent image processing operations. The hybrid watermark can be used to accurately pinpoint changes as well as distinguish malicious tamper from innocent operations. The authentication can be done without accessing any information about the original image. Examples of tamper detection on real imagery are given. Powerful publicly available image processing software packages such as Adobe PhotoShop or PaintShop Pro make digital forgeries a reality. Feathered cropping enables replacing or adding features without causing detectable edges. It is also possible to carefully cut out portions of several images and combine them together while leaving barely detectable traces. Thus, the classical forensic techniques are not readily applicable to digital imagery.
Compressive (Microscan) Receivers (2005)

The name compressive receiver is given to this kind of receiver because a dispersive delay line (DDL) is used to compress the input radio-frequency (RF) signal to a narrow pulse. It is also referred to as a microscan receiver because a fast sweeping local oscillator (LO) is used to convert the input signals to frequency-modulated (FM) signals. The idea of using a DDL to measure frequency was patented in 1960. The advances in surface acoustic wave (SAW) technology and high-speed logic circuits have revitalized the interest in developing compressive receivers. This chapter discusses compressive receivers for electronic warfare application. It proves the principle of operations, mathematical analysis, and design considerations for compressive receivers.
ChemInform Abstract: Lipase‐Catalyzed Synthesis of Optically Active Amides in Organic Media. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Temporal control of urate oxidase activity during development of the third‐instar larva of Drosophila: The role of 20‐hydroxyecdysone (1982)

Abstract The tissue‐specific enzyme urate oxidase is confined exclusively to the Malpighian tubules of Drosophila melanogaster and expressed only in the third‐instar larva and the adult. Shortly before pupariation urate oxidase activity declines precipitously and is not detectable 24 hours later. That 20‐hydroxyecdysone is the factor that triggers the disappearance of urate oxidase activity in late third‐instar larvae is demonstrated using the temperature sensitive mutant ecd 1 which at the nonpermissive temperature of 29°C fails to accumulate a sufficient concentration of 20‐hydroxyecdysone necessary for puparium formation and thus remains a third‐instar larva for 1 to 2 weeks before death. Both the life cycle and the temporal profile of urate oxidase activity in ecd 1 larvae at 19°C is identical to that of the wild type. However, at 29°C ecd 1 third‐instar larvae retain high urate oxidase activity. A precipitous decline in urate oxidase activity is observed when ecd 1 larvae at 29°C are fed 20‐hydroxyecdysone. These data implicate 20‐hydroxyecdysone in the process that controls the rapid decline of urate oxidase activity at the time of puparium formation. In whole homogenates of Malpighian tubules, the urate oxidase polypeptide was identified in SDS‐polyacrylamide gels by its Rf with respect to homogeneously pure Drosophila urate oxidase and also by immunoprecipitation with rabbit anti‐Drosophila urate oxidase IgG. Throughout development the amount of the urate oxidase polypeptide is correlated with the magnitude of urate oxidase activity.
Strategies for Generating Prolonged Functional Standing Using Intramuscular Stimulation or Intraspinal Microstimulation (2007)

Spinal cord injury (SCI) often results in the loss of the ability to stand. The goal of this study was to implement a functional electrical stimulation (FES) system for restoring prolonged periods of standing after SCI. For this purpose, we tested two control strategies: open-loop and closed-loop control, and two stimulation paradigms: non-interleaved intramuscular stimulation (IM-S) and interleaved intraspinal microstimulation (ISMS). The experiments were conducted in anesthetized cats. Stimulation was applied to the muscles through IM-S electrodes implanted in the main knee and ankle extensor muscles, or to the spinal cord through ultra-fine ISMS wires implanted within the ventral horn of the lumbosacral enlargement. The cats were partially supported over parallel force plates and accelerometers were secured to the hindlimbs above and below the ankle joint. Ground reaction forces and knee and ankle joint angles were measured by the force plates and accelerometers, respectively. The closed-loop controller used these feedback signals to modulate the amplitude of stimulation applied to the extensor muscles. The open-loop controller applied constant levels of stimulation which were determined before the onset of each trial. The duration of standing achieved using closed-loop control of IM-S was significantly longer than that achieved with open-loop control (approximately 2 times longer). The increase in the duration of standing corresponded with a decrease in the rate of force decay and a lower average injected current during closed-loop control. Standing was further improved with the use of ISMS. Closed-loop control of interleaved ISMS resulted in a period of standing > 3 times longer than the best trial generated using non-interleaved IM-S. There was also a significant improvement in the balance of force between the two hindlimbs. The results suggest that a system which uses closed-loop control in conjunction with interleaved ISMS could achieve prolonged FES standing in people with SCI.
Mécanique des matériaux à topologie autobloquante (2007)

Les matériaux à topologie autobloquante sont un nouvel exemple de "matériaux hybrides", intermédiaires entre les matériaux et les structures, tout comme les composites, les mousses structurales, les matériaux enchevêtrés, les structures sandwich. Ils sont constitués de blocs élémentaires ajustés périodiquement et maintenus en contact par des conditions aux limites de compression. Nous avons étudié expérimentalement l'influence du coefficient de frottement et des conditions limites sur le comportement en indentation d'assemblages de blocs ostéomorphes réalisés en glace. Nous avons modélisé par éléments finis le contact avec frottement entre deux blocs ostéomorphes élastiques, en fonction du confinement par les autres blocs et du coefficient de frottement. Nous implémentons actuellement un code C++ basé sur la méthode des éléments discrets qui utilisera les lois locales déterminées par éléments finis pour simuler le comportement élastique et l'endommagement de grandes structures autobloquantes.
Mitigating the influence of industrially relevant disturbances on LME severity of dissimilar resistance spot welded advanced high-strength steels (2023)

The third generation of advanced high-strength steels (3G-AHSS) has been developed to provide high strength and high ductility, which attract automakers. To protect these materials from corrosion during service, these materials are typically coated with zinc. During resistance spot welding (RSW), the zinc coating can melt, allowing it to penetrate into the grain boundaries (GBs), and lead to liquid metal embrittlement (LME) phenomena. Concerns regarding LME susceptibility have impacted the industrial application of 3G-AHSS; therefore, its mitigation has become a top focus for automakers. Several possible strategies for lowering LME severity by altering welding parameters have been proposed to mitigate LME in similar spot weld joints. However, these strategies were not tested on a dissimilar spot weld joint. Therefore, in this work, 1.4 mm gauge thickness galvanized (GI-coated) 3G-980 AHSS was joined with 0.6 mm thick Interstitial Free (IF) steel. In this work, current pulsation and ultra-short hold time were proposed to minimize LME severity. The robustness of the developed welding schedule was then tested on welds made with industrial disturbance factors such as pre-strained sheets (between 0 to 80% of 3G-980 material yield strength) and electrode misalignment (between 0° to 10° misalignment) compared to baseline parameters. In severe circumstances of disturbance factors, the resulting optimized welding schedule decreased LME cracking and showed improved resistance to LME, lowering LME severity by 41% for the extreme pre-strain condition and 27% for the extreme misalignment angle.
The effects of an elastic solid surface layer on the radial pulsations of gas bubbles (1995)

Most previous theoretical investigations of gas bubble dynamics have assumed an uncontaminated gas–liquid interface. Recently, however, the potential importance of layers of surface active agents on bubble dynamics has been increasingly recognized. In this work it is assumed that a continuous layer of incompressible, solid elastic material separates the gas from the bulk Newtonian liquid. Elasticity is modeled to include viscous damping. A Rayleigh–Plesset-like equation describing the dynamics of such surface-contaminated gas bubbles is derived. The equation predicts that the surface layer supports a strain that counters the Laplace pressure and thereby stabilizes the bubble against dissolution. An analytical solution to this equation which includes both the fundamental and second-harmonic response is presented. The dispersion relation describing the propagation of linear pressure waves in liquids containing suspensions of these bubbles also is presented. It is found that (1) the resonance frequencies of individual bubbles tend to increase as the modulus of rigidity increases; (2) the damping provided by the viscosity of the shell dominates thermal effects for bubble radii less than ∼10 μm; (3) the attenuation coefficient in a bubbly liquid decreases as either the rigidity or the viscosity of the surface layer increases; (4) encapsulated bubbles with shell rigidity greater than ∼85 MPa provide a greater total scattering cross section per unit attenuation in the lower biomedical frequency range than do free bubbles of the equivalent size.
Pluripotent human stem cells for the treatment of retinal disease (2011)

Despite advancements made in our understanding of ocular biology, therapeutic options for many debilitating retinal diseases remain limited. Stem cell-based therapies are a potential avenue for treatment of retinal disease, and this mini-review will focus on current research in this area. Cellular therapies to replace retinal pigmented epithelium (RPE) and/or photoreceptors to treat age-related macular degeneration (AMD), Stargardt's macular dystrophy, and retinitis pigmentosa are currently being developed. Over the past decade, significant advancements have been made using different types of human stem cells with varying capacities to differentiate into these target retinal cell types. We review and evaluate pluripotent stem cells, both human embryonic stem cells and human induced pluripotent stem cells, as well as protocols for differentiation of ocular cells, and culture and transplant techniques that might be used to deliver cells to patients.
Energy efficient prefetching and caching (2004)

Permission is granted for noncommercial reproduction of the work for educational or research purposes.
El contrato de concesión de obras públicas y su financiación privada (2011)

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Blood Velocity in an Experimental Iris Tumor (1998)

* BACKGROUND AND OBJECTIVE: Greene strain melanoma was implanted into the irides of eight nonpigmented rabbits to evaluate the blood flow in tumor vasculature. * MATERIALS AND METHODS: Conventional scanning laser ophthalmoscopy was used in conjunction with fluorescent microsphere angiography (FMA). Changes were documented on SVHS videotape for later analysis. Individual microsphere movement was tracked through the tumor vessels. Subsequently, blood velocity measurements were taken. * RESULTS: The tumor vessels were poorly organized and inefficient. Tumor blood velocity was up to 2.5 times slower compared with normal blood velocity in the unaffected iris of the same eye of the same rabbit (P = .05). Tumor blood flow could be qualitatively visualized in real time in the live rabbit model. * CONCLUSION: The ability to visualize fluorescent microspheres within the poorly organized tumor vasculature coupled with the reduced blood velocity in the tumor helps to explain the success of hyperthermic tumoricidal therapy, and may allow for development of more efficient and selective drug delivery systems and tumoricidal agents. [Ophthalmic Surg Lasers 1998;29:506-509.]
Supplementary Figure 2 from A Targeted RNAi Screen of the Breast Cancer Genome Identifies <i>KIF14</i> and <i>TLN1</i> as Genes That Modulate Docetaxel Chemosensitivity in Triple-Negative Breast Cancer (2023)

&lt;p&gt;PDF File - 35K, Annexin V staining by flow cytometry 24 hours after addition of 1nM docetaxel to MDA-MB-231 cells.&lt;/p&gt;