gebhart/patrepeval huggingface dataset:
Fully Soft 3D-Printed Electroactive Fluidic Valve for Soft Hydraulic Robots (2018)

Soft robots are designed to utilize their compliance and contortionistic abilities to both interact safely with their environment and move through it in ways a rigid robot cannot. To more completely achieve this, the robot should be made of as many soft components as possible. Here we present a completely soft hydraulic control valve consisting of a 3D-printed photopolymer body with electrorheological (ER) fluid as a working fluid and gallium-indium-tin liquid metal alloy as electrodes. This soft 3D-printed ER valve weighs less than 10 g and allows for onboard actuation control, furthering the goal of an entirely soft controllable robot. The soft ER valve pressure-holding capabilities were tested under unstrained conditions, cyclic valve activation, and the strained conditions of bending, twisting, stretching, and indentation. It was found that the max holding pressure of the valve when 5 kV was applied across the electrodes was 264 kPa, and that the holding pressure deviated less than 15% from the unstrained max holding pressure under all strain conditions except for indentation, which had a 60% max pressure increase. In addition, a soft octopus-like robot was designed, 3D printed, and assembled, and a soft ER valve was used to stop the fluid flow, build pressure in the robot, and actuate six tentacle-like soft bending actuators.
Minimally Invasive Iliac Crest Bone Graft Harvesting: A Design and Business Method Overview (2011)

Bone grafts are used commonly in spinal fusion procedures to induce the fusion of adjacent spinal vertebrae. Autologous bone graft (autograft) is taken from the patient’s own bone. This bone graft provides the best fusion rates; however, obtaining the bone graft requires a secondary incision that is time consuming to the surgeon and very painful to the patient. Alternative commercial bone graft solutions exist as well. However, these alternatives produce worse clinical outcomes and greatly increase the cost of health care. We propose a novel medical device for the minimally invasive extraction of autologous bone graft from the iliac crest of a patient. This device will allow physicians to achieve high fusion rates without burdening the hospital with the high costs of alternative products. Here, we overview our current design at a systems level and we demonstrate the market potential for the proposed device and outline a commercialization strategy for bringing this device to market.
Energetics of quaternary III-V alloys described by incorporation and clustering of impurities (2009)

The energetics of alloy formation is generally modeled either by explicit sampling of the possible alloy configurations or by considering only noninteracting impurities in the dilute limit. We describe a model that bridges the two approaches by taking into account the thermodynamic probability to form small clusters by association of impurities, thereby extending the validity of the impurity model to higher concentrations. Since we express the alloy energetics in terms of pair and cluster binding energies there is no need for computationally intensive sampling over the full configuration space. The application to the ${\text{Ga}}_{1\ensuremath{-}x}{\text{In}}_{x}{\text{P}}_{1\ensuremath{-}y}{\text{N}}_{y}$ highlights the importance of short-range ordering due to ``small atom/large atom'' correlation in such quaternary III-V alloys.
Genetic--epidemiologic study of early-onset ischemic heart disease. (1980)

A genetic-epidemiologic study was undertaken of a white Colorado population of 207 patients who had a myocardial infarction before age 55 years. Nineteen independent variables were compared between the 207 cases and 621 controls, matched 3:1. The highest risk ratios were associated with a positive family history for ischemic heart disease (IHD). The heritability of IHD was 63% when families with the monogenic forms of hyperlipoproteinemia were included, and 56% when they were excluded. A risk index was developed that incorporates family history into a data base of risk factors, which can be readily assessed by the clinician obtaining a screening history, physical and standard laboratory tests. A scale of 0-10 was devised and the predictive value of the index was tested against another data set. The efficiency of the index was maximal at a screening level of 5. This study suggests that it is logistically feasible to seek patients at high risk for intensive management in a clinical setting (high-risk strategy) using risk indices similar to the one developed for this study, which emphasize the very important familial component to IHD.
Physical Metaphor for Streaming Media Retargeting (2014)

We here introduce an image/video retargeting method that operates arbitrary aspect ratios resizing achieved in real-time performances. Most of the literature retargeting approaches sacrifice real-time performances in behalf of quality. On the other hand, existing fast methods provide arguable results. We can obtain a valuable trade-off between effectiveness and efficiency. The method named Spring Simulation Retargeting (SSR) is mainly based on a physical springs-based simulation. The media are assumed as flexible objects composed of particles and springs with different local stiffness properties, related to the visual importance of the content. The variation of the object size generates elastic forces which determine a new arrangement of the particles, according to the elongation of their connected springs. The deformations are mostly introduced in regions where low importance content is present, while high saliency regions are preserved as desired. The proposed method is evaluated and compared both for images and videos, against several state of the art methods and a user study is taken to assess the results, showing the value of the approach.
Robotic lake lander test bed for autonomous surface and subsurface exploration of Titan lakes (2012)

We introduce a robotic lake lander test bed that can be operated either stand-alone or as part of a Tier-Scalable Reconnaissance mission architecture to study and field test an integrated hardware and software framework for fully autonomous surface and subsurface exploration and navigation of liquid bodies. The lake lander is equipped with both surface and subsurface sensor technologies. Our particular focus is on Saturn's moon Titan with its hydrocarbon lakes with respect to future missions involving lake landers (e.g., Titan Mare Explorer (TiME) mission), potentially in conjunction with balloons/airships and orbiter-support overhead. This test bed serves as an analog to a Titan unpiloted surface vessel equipped with its own onboard realtime navigation and hazard avoidance system, surface and subsurface exploration sensor suite, and autonomous science investigation software system. As such the test bed helps map out a technical path toward true autonomy for the robotic exploration of the Solar System.
Polymerized hemoglobin restores cardiovascular and kidney function in endotoxin-induced shock in the rat. (1997)

Sepsis and its complications, hypotension, shock, and multiorgan failure continue to represent a significant cause of mortality among hospitalized patients, affecting approximately 200,000 patients per year in the US and 100,000 in Europe (Dal Nogare, A.R. 1991. Am. J. Med. Sci. 302:50-65.). Incidence rates appear to be increasing, probably due to an increase in the population with risk factors such as diabetes or invasive procedures. Activation of cytokines by endotoxins and subsequent formation of nitric oxide is of central pathogeneic importance in sepsis. In this study we show that polymerized bovine hemoglobin (Biopure 2) restores both cardiovascular and renal functions in an endotoxin-induced shock model in rats. These effects are compared to those of the nitric oxide synthase inhibitor N(G)-nitro-L-arginine, and hydroxyethyl starch, the latter currently in clinical use for intravenous volume replacement. Our results clearly indicate that polymerized hemoglobin but not nitric oxide synthase inhibition or volume replacement normalize cardiovascular and kidney function in acute septic shock. This new therapeutic approach is readily applicable to controlled clinical trials because polymerized hemoglobin has been tested in humans and is therefore available for such studies.
Synergism of Antifungal Activity between Mitochondrial Respiration Inhibitors and Kojic Acid (2013)

Co-application of certain types of compounds to conventional antimicrobial drugs can enhance the efficacy of the drugs through a process termed chemosensitization. We show that kojic acid (KA), a natural pyrone, is a potent chemosensitizing agent of complex III inhibitors disrupting the mitochondrial respiratory chain in fungi. Addition of KA greatly lowered the minimum inhibitory concentrations of complex III inhibitors tested against certain filamentous fungi. Efficacy of KA synergism in decreasing order was pyraclostrobin > kresoxim-methyl > antimycin A. KA was also found to be a chemosensitizer of cells to hydrogen peroxide (H₂O₂), tested as a mimic of reactive oxygen species involved in host defense during infection, against several human fungal pathogens and Penicillium strains infecting crops. In comparison, KA-mediated chemosensitization to complex III inhibitors/H₂O₂ was undetectable in other types of fungi, including Aspergillus flavus, A. parasiticus, and P. griseofulvum, among others. Of note, KA was found to function as an antioxidant, but not as an antifungal chemosensitizer in yeasts. In summary, KA could serve as an antifungal chemosensitizer to complex III inhibitors or H₂O₂ against selected human pathogens or Penicillium species. KA-mediated chemosensitization to H₂O₂ seemed specific for filamentous fungi. Thus, results indicate strain- and/or drug-specificity exist during KA chemosensitization.
Identification and characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts reveals their constitutive expression in leukemic and pre-leukemic clones (2016)

Abstract Bovine Leukemia Virus (BLV) is a deltaretrovirus closely related to the Human T-cell leukemia virus-1 (HTLV-1). Cattle are the natural host of BLV where it integrates into B-cells and produces a lifelong infection. Most infected animals remain asymptomatic but following a protracted latency period about ∽5% develop an aggressive leukemia/lymphoma, mirroring the disease trajectory of HTLV-1. The 5’LTRs of both the BLV and HTLV-1 proviruses are transcriptionally silent in tumors, however they are not entirely quiescent, with the HLTV-1 antisense transcript HBZ and the BLV microRNAs constitutively expressed in tumors. Here, using RNA-seq, we demonstrate that in addition to microRNAs, the BLV provirus also constitutively expresses two antisense transcripts in all BLV infected samples examined. The first transcript (AS1) has alternate potential polyadenylation sites generating a short transcript of ∽600bp (aS1-S) and a less abundant longer transcript of ∽2200bp (AS1-L). Alternative splicing also creates a second transcript of ∽400bp (AS2) utilizing the first exon of AS1. Production of AS transcripts from the 3’LTR was supported by reporter assays demonstrating that the BLV LTR has substantial and Tax-independent antisense promoter activity. BLV AS transcripts predominantly localize in the nucleus. Examination of protein coding potential showed AS2 to be non-coding, while the AS1-S/L transcripts coding potential is ambiguous, with a small potential open reading frame (ORF) of 264bp present. The AS1-L transcript overlaps the BLV microRNAs transcribed in the sense direction. Using high throughput sequencing of RNA-ligase-mediated (RLM) 5’ RACE products, we show that the perfect complementary between the transcripts leads to RNA-induced silencing complex (RISC) mediated cleavage of AS1-L. Furthermore, experiments using BLV proviruses where the microRNAs were removed or inverted point to additional transcriptional interactions between the two viral RNA species. Knock down of AS1-S/L using locked nucleic acids (LNAs) showed no obvious effect on the cells phenotype. While a detailed elucidation of the BLV antisense transcripts function remains in the future, the constitutive expression in all samples examined, points to a vital role for the transcripts in the life cycle and oncogenic potential of BLV.
Characterization of protons accelerated from a 3 TW table-top laser system (2017)

Characterization of protons accelerated from a 3 TW table-top laser system, Bellido, P., Lera, R., Seimetz, M., Cruz, A. Ruiz-de la, Torres-Peirò, S., Galán, M., Mur, P., Sánchez, I., Zaffino, R., Vidal, L., Soriano, A., Sánchez, S., Sánchez, F., Rodríguez-Álvarez, M.J., Rigla, J.P., Moliner, L., Iborra, A., Hernández, L., Grau-Ruiz, D., González, A.J., García-Garrigos, J.J., Díaz-Caballero, E., Conde, P., Aguilar, A., Roso, L., Benlloch, J.M.
Polarization dependence of absorption and laser induced surface damage thresholds in wire grid polarizers (1989)

We report a theoretical and experimental study of the absorption of wire grid polarizers vs orientation and wavelength. Measurement of absorption and surface damage thresholds are in good agreement with the theory.
An electron microscope study of gametangia in the green seaweed Halimeda tuna (1994)

Abstract The gametangia of the green seaweed Halimeda tuna are spherical bodies of diameter up to 250–300 μm. They are clustered in groups of 8–10 on hundreds of threads sprouting from all pale white segments of the fertile individuals. In addition to gametes, starch-containing chloroplasts, naked starch grains and two types of spherical bodies different in size and ultrastructure are the main corpuscular components. A layer of amorphous material of irregular thickness underlies the walls which are finely and evenly rough, structureless, electron translucent and 1–1.5 μm thick. Gametangia with superficial wall warts were found also.
Reliable Recall of Spontaneous Activity Patterns in Cortical Networks (2009)

Irregular ongoing activity in cortical networks is often modeled as arising from recurrent connectivity. Yet it remains unclear to what extent its presence corrupts sensory signal transmission and network computational capabilities. In a recurrent cortical-like network, we have determined the activity patterns that are better transmitted and self-sustained by the network. We show that reproducible spiking and subthreshold dynamics can be triggered if the statistics of the imposed external drive are consistent with patterns previously seen in the ongoing activity. A subset of neurons in the network, constrained to replay temporal pattern segments extracted from the recorded ongoing activity of the same network, reliably drives the remaining, free-running neurons to call the rest of the pattern. Comparison with surrogate Poisson patterns indicates that the efficiency of the recall and completion process depends on the similarity between the statistical properties of the input with previous ongoing activity The reliability of evoked dynamics in recurrent networks is thus dependent on the stimulus used, and we propose that the similarity between spontaneous and evoked activity in sensory cortical areas could be a signature of efficient transmission and propagation across cortical networks.
Pharmacodynamic effects of the fetal estrogen estetrol in postmenopausal women: results from a multiple-rising-dose study (2017)

In this study, estetrol treatment showed dose-dependent estrogenic effects on endocrine parameters, bone turnover markers, and lipids and lipoproteins. The effect on triglycerides was small as were the effects on hemostatic variables. These results support the further investigation of estetrol as a candidate for hormone therapy. Quantitatively, the effects of 10 mg estetrol were similar to the study comparator 2 mg estradiol valerate.
Determination of surface nematic liquid crystal anchoring strength using nano-scale surface grooves (2013)

Based on several nano-scale groove models, we propose a new technique to simultaneously determine the azimuthal and polar surface anchoring strengths of nematic liquid crystal (LC). The optical analysis of LCs on a grooved surface made by nanoimprinting lithography was performed on special alignment material, using a typical rubbing process. In our approach, using a polarizing microscope, we can determine the LC alignment exactly as it is in a parallel state, rather than a twisted state. This simple proposed method gives an accurate value of the surface LC anchoring of various surfaces, as well as simultaneously measuring the azimuthal and polar anchoring energy.
Identifying the Specific Causes and the Determinants of Outcome in Kidney Recipients with Transplant Glomerulopathy (2018)

Background Understanding the specific causes of TG and its long-term consequences at population scale is lacking. Methods This study includes all kidney allograft biopsies performed between January 2004 and January 2014 in three French referral centers and one Canadian center showing TG (Banff cg score≥1 by light microscopy). All TG cases were extensively phenotyped and systematically assessed using light microscopy, immunohistochemistry (IH), immunofluorescence (IF), together with circulating anti-HLA-DSA at the time of biopsy. Results Among the 8,207 post-transplant allograft biopsies performed during the inclusion period, 552 (6.7%) presented with double contours and corresponded to 385 patients. Three predominant overlapping etiologies accounted for 466 (84.4%) cases. 417 biopsies showed antibody-mediated injury (75.5%), 90 biopsies showed TMA (16.3%), 65 showed MPGN (11.8%), while 86 (15.6%) remained equivocal with no specific cause identified (Figure 1). The median time of TG diagnosis post-transplant was 33.18 months (IQR: 12.12 – 78.72 months). Kidney allograft survival after TG diagnosis was 69.4% at 3 years, 57.1% at 5 years, 43.3% at 7 years and 25.5% at 10 years (Figure2). After adjusting for donor, recipient and transplant characteristics, immunological and histological parameters, we identified the following independent factors associated with long-term allograft survival in patients with TG: eGFR (HR: 0.96; CI 95% (0.95-0.98); p<0.001) and proteinuria level (squared transformation) (HR: 2.16; CI 95% (1.76-2.65); p<0.0001) at the time of biopsy, deceased donor (HR: 1.62; CI 95% (1.11-2.40); p=0.016), delay between transplantation and TG diagnosis (log transformation) (HR:1.31; CI 95% (1.16-1.49); p<0.001), vasculitis Banff score (HR: 1.66; IC 95% (1.04-2.65); p=0.032) and TG biopsy with ongoing disease process (HR: 1.55; IC 95% (1.01-2.391); p=0.047). Conclusion Using a large cohort of kidney recipients with a diagnosis of TG and a systematic phenotyping, we identify three overlapping pathways in TG: ABMR, TMA and MPGN. The identification of the main independent determinants of TG prognosis may help improving risk stratification and define specific causes and disease process in patients with TG.
Value of the venous-arterial PCO2 gradient to reflect the oxygen supply to demand in humans (1998)

deltaPCO2 can be reliably used at the bedside for informing on the adequacy of CI with respect to a given metabolic condition, and particularly for detecting changes in oxygen demand (e.g., the changes accompanying drug-induced changes in CI). In this regard, deltaPCO2, together with O2 ER and SVO2, can help to assess the adequacy of CI to global oxygen demand.
Role of Some Agricultural and Industrial By‐products in Modifying Soil Physical Properties (1980)

Abstract In a pot culture study, saw dust, vermiculite, lignite, magnesium oxide, wheat straw, paddy shell, ground nut shell and farm yard manure (FYM) were incorporated in to wet sandy loam and clay soils at the rate of 30 g/kg. Relative changes in soil structure and moisture retention were evaluated at the end of 160 day incubation period. All the amendments except vermiculite, ground nut shell and FYM in sandy loam soil and except vermiculite, lignite, magnesium oxide in clay soil significantly increased MWD and aggregates &gt; 1 mm. Structural index was significantly improved by all the amendments except vermiculite and FYM in sandy loam and vermiculite and magnesium oxide in clay soil. Moisture retention and release in clay soil in the wet range (0 to 0.33 bar) were considerably increased by soil amendments except magnesium oxide, vermiculite and lignite. Almost all the amendments significantly increased moisture retention in the wet range in sandy loam soil. However, moisture release at 50 mbar was reduced only by wheat straw in sandy loam soil.
Macromol. React. Eng. 5–6/2011 (2011)

Cover: A combination of two metallocene catalysts, each with different comonomer incorporation capabilities, can be used to tailor-make chemical composition distribution characteristics of ethylene/1-olefin copolymers by following the appropriate copolymerization recipe obtained from the proposed bimodality criterion. Further details can be found in the article by K. Narkchamnan, S. Anantawaraskul,* and J. B. P. Soares on page 198.
Development and assessment of sensitive immuno‐PCR assays for the quantification of cerebrospinal fluid three‐ and four‐repeat tau isoforms in tauopathies (2012)

Characteristic tau isoform composition of the insoluble fibrillar tau inclusions define tauopathies, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and frontotemporal dementia with parkinsonism linked to chromosome 17/frontotemporal lobar degeneration-tau (FTDP-17/FTLD-tau). Exon 10 splicing mutations in the tau gene, MAPT, in familial FTDP-17 cause elevation of tau isoforms with four microtubule-binding repeat domains (4R-tau) compared to those with three repeats (3R-tau). On the basis of two well-characterised monoclonal antibodies against 3R- and 4R-tau, we developed novel, sensitive immuno-PCR assays for measuring the trace amounts of these isoforms in CSF. This was with the aim of assessing if CSF tau isoform changes reflect the pathological changes in tau isoform homeostasis in the degenerative brain and if these would be relevant for differential clinical diagnosis. Initial analysis of clinical CSF samples of PSP (n = 46), corticobasal syndrome (CBS; n = 22), AD (n = 11), Parkinson's disease with dementia (PDD; n = 16) and 35 controls revealed selective decreases of immunoreactive 4R-tau in CSF of PSP and AD patients compared with controls, and lower 4R-tau levels in AD compared with PDD. These decreases could be related to the disease-specific conformational masking of the RD4-binding epitope because of abnormal folding and/or aggregation of the 4R-tau isoforms in tauopathies or increased sequestration of the 4R-tau isoforms in brain tau pathology.
Impaired Basal Thermal Homeostasis in Rats Lacking Capsaicin-sensitive Peripheral Small Sensory Neurons (2007)

We studied the effects of selective loss of capsaicin-sensitive primary sensory neurons on thermosensation and thermoregulation in rats. Neonatal capsaicin treatment in rats caused a remarkable decrease in the number of small-diameter neurons in the dorsal root ganglion (DRG) compared with their number in the control rats. Gene expression analysis for various thermo-sensitive transient receptor potential (TRP) channels indicated marked reductions in the mRNA levels of TRPV1 (70%), TRPM8 (46%) and TRPA1 (64%), but not of TRPV2, in the DRG of capsaicin-treated rats compared with those in the control rats. In addition to the heat and cold insensitivity, capsaicin-treated rats showed lower rectal core temperature, higher skin temperature and decreased sensitivity to ambient temperature alteration under normal housing at room temperature, suggesting impaired thermosensation and change in thermoregulation in the rats. Uncoupling protein 1 (UCP1) expression and the thermogenic ability in brown adipose tissues were attenuated in the capsaicin-treated rats. These results indicate a critical role of capsaicin-sensitive sensory neurons in both heat and cool sensation and hence in basal thermal homeostasis, which is balanced by heat release and production including UCP1 thermogenesis, following sensation of the ambient temperature.