gebhart/patrepeval huggingface dataset:
Experimental investigation of geometry and flow effects on acoustic radiation from duct inlets (1983)

An experimental study of the effects of geometry, flow, frequency and source structure on the radiation and reflection of sound from duct inlets has been conducted. This work extends a previous study by comparing two inlet shapes typical of static and flight testing and by considering higher order radial modes. Measurements of the internal and radiated acoustic fields are presented in terms of modal reflection coefficients and absolute radiated pressure directivity. Results indicate that geometry effects associated with these practical inlet shapes become less important for a fixed cutoff ratio as the mode order and frequency are increased. Also, static inflow, while reducing the reflected wave amplitude, is shown to have little effect on radiation directivity regardless of inlet geometry.
Deep Shape from Polarization (2019)

This paper makes a first attempt to bring the Shape from Polarization (SfP) problem to the realm of deep learning. The previous state-of-the-art methods for SfP have been purely physics-based. We see value in these principled models, and blend these physical models as priors into a neural network architecture. This proposed approach achieves results that exceed the previous state-of-the-art on a challenging dataset we introduce. This dataset consists of polarization images taken over a range of object textures, paints, and lighting conditions. We report that our proposed method achieves the lowest test error on each tested condition in our dataset, showing the value of blending data-driven and physics-driven approaches.
Bleomycin-Mediated Electrochemotherapy of Metastatic Melanoma (1996)

This is the first study that documents the antitumor effects of ECT in metastatic melanoma. Although not a cure, it may be an effective alternative to palliative surgery or irradiation in these patients.
Human retinal development: Ultrastructure of the outer retina (1973)

Abstract The morphogenesis of the outer human retina from 6.5 to 18 weeks of gestational age (16–156 mm) was studied by light and electron microscopy. During this period the retinal pigment epithelium changes from a pseudostratified columnar epithelium, with mitoses at its inner edge, to a single layer of cuboidal cells. Initially, mature pigment granules, premelanosomes, polysomes, rough endoplasmic reticulum and a Golgi complex occupy the epithelial cytoplasm. Lateral epithelial surfaces show infoldings and neighboring epithelial cells are bound at their inner borders by a junctional complex consisting of a zonula occludens and zonula adherens. Later, pigment epithelial development is marked by an increase in cytoplasmic organelle content and the appearance of slender processes at the inner epithelial border. Initially, the outer neural retina is formed by a uniform population of elongated cells containing oval nuclei with multiple nucleoli and, in the cytoplasm, mitochondria, polysomes and the Golgi complex. Cell division is common in the proliferative layer at the outer edge of the posterior neural retina until 120 mm crown‐rump length, and cell membrane junctions between outer neuroblasts remain intact during mitosis. Cilia project outwards from outer neuroblasts and invaginate the immediately adjacent pigment epithelium. At 120 mm crown‐rump length, differentiating rods, cones and Müller cell processes are distinguishable and developing ribbon synapses and surface contacts are present at the base of the cone prior to outer segment formation.
Production and Antifungal Activity of Cordytropolone and (-)-Leptosphaerone A From the Fungus Polycephalomyces nipponicus (2019)

Cordytropolone (1) and (−)-leptosphaerone A (2) were isolated from the culture broth of the fungus Polycephalomyces nipponicus. The structures of these two compounds were elucidated by spectroscopic methods and from a comparison of the spectroscopic data with those reported previously. The structure of 1 was confirmed by X-ray crystallography for the first time while the leptosphaerone class (compound 2) was first isolated as its (+)-antipode from the fungus Polycephalomyces ( Cordyceps). The fermentation process was monitored weekly by High performance liquid chromatography analysis for 10 weeks. The predominant compound (1) was produced at ~0.65 mg/mg of dry extract at week 9. Compound 1 exhibited modest antipathogenic fungal activity against Collectrichum musae, Colletotrichum capsici, Colletotrichum gloeosporioides, Fusarium spp. TFPK301, F. spp. FOC1708, and Pestalotia spp. with percentage of mycelial growth inhibition values of 3.74 ± 0.70%, 12.86 ± 1.43%, 0.91 ± 0.56%, 5.46 ± 0.56%, 7.93 ± 0.61%, and 18.75 ± 5.24%, respectively, at 25 μg/mL.
Ultra-Sensitive and Broad Range Phononic-Fluidic Cavity Sensor for Determination of Mass Fractions in Aqueous Solutions (2019)

This paper presents a 3D-printed phononic-fluidic cavity sensor to measure volumetric physical properties of a liquid. This device features a new type of acoustic fluid sensor with very high, linear sensitivity in a very broad concentration range, solid-air 3D phononic crystal layers confining a fluidic cavity resonator to generate a strong, well separated cavity resonance within the phononic band gap, and ultra-sensitive determination of sodium chloride and glucose concentrations in aqueous solutions. For NaCl solutions in a device with a cavity resonance around 200 kHz we measure a sensitivity of 1.4 kHz / % resulting in a high resolution of 350 ppm over a concentration range of 0% – 23%.
Clinical Epidemiology Regarding Clinical and Pathophysiological Features of Japanese Patients with Type 2 Diabetes Mellitus (2013)

2型糖尿病は遺伝背景や生活習慣・環境が深く関与することから，その臨床像に大きな人種・民族差（ethnic differences）が存在する．これは基礎的病態から各合併症のリスク因子に至るまで多岐にわたり，たとえばインスリン分泌能やインスリン抵抗性と関連する肥満度は，わが国の患者では欧米人患者より大幅に低い．さらにわが国に多い喫煙が腎症のリスク因子であったり，わが国で少ない果物摂取量と網膜症発症が有意に関連していたりなど，生活習慣との関連も見られる．したがって診療ガイドラインを作成したり，大規模臨床エビデンスを実地診療に適用したりする際には，これらの違いについて十分な配慮が必要である．日本人に最適化された糖尿病予防・治療対策の確立のためには，日本人における大規模臨床研究をさらに推進しデータを集積していく必要がある．
Optimisation of pressurised liquid extraction for antioxidative polyphenolic compound from Momordica charantia using response surface methodology (2016)

Summary Pressurised liquid extraction (PLE) of antioxidant compounds from bitter gourd fruits ( Momordica charantia ) in aqueous ethanolic solvent was investigated using response surface methodology at laboratory scale to understand key impact of extraction variables. Extraction efficiency was optimised by measuring the yield of extraction, total phenolic content (TPC), total flavonoid content (TFC), ferric reducing/antioxidant power assay (FRAP) and radical scavenging activity (RSA). The optimal extraction conditions were reached at 80% ethanol concentration, 10‐min extraction time and at 160 °C. Under these extraction conditions, values of TPC (5.40 ± 0.30 g GAE per 100 g), TFC (1.50 ± 0.10 g QE per 100 g), FRAP (778.55 ± 10 μmol eq Fe (II) g −1 ), yield (178.50 ± 5.50 mg g −1 dc) and RSA (75.50 ± 4.50%) were achieved. Furthermore, statistical analysis revealed that antioxidative attributes of bitter gourd extract were strongly and positively correlated with extraction temperature and ethanol concentration rather than processing time. This study illustrated that PLE has the potential to extract antioxidant compounds from tropical fruit vegetables in an accelerated manner. Furthermore, influential parameters affecting the process could be optimised for further industrial intake.
PDTM-34. TARGETING H3.3G34R/V RE-WIRING OF THE EPIGENOME IN PAEDIATRIC GLIOBLASTOMA OF CHILDREN AND YOUNG ADULTS (2018)

Around 15% of cerebral hemispheric glioblastomas (GBM) of children and young adults harbour G34R/V mutations in H3F3A, encoding the histone H3.3 variant. These tumours have a peak incidence in late adolescence but are found up to 30yrs of age, and have conflicting data as to their prognosis compared to histone wild-type cases. As little is known about its role in tumorigenesis, we sought to explore the underlying biology of H3.3G34R/V mutant GBM and identify novel avenues for therapeutic intervention through genomic, epigenomic and drug screening approaches in primary-patient-derived cultures. In combined retrospective and prospective cohorts of pHGG samples, H3.3G34R/V tumours formed a highly distinct methylation subgroup marked by global hypomethylation. They are enriched in several whole chromosomal arm DNA copy number losses, which at 4q appears to converge along with somatic mutation on the F-box protein family member FBXW7, known to play a role in MYCN stabilization. MYCN was previously identified to be differentially bound by H3K36me3, and we further identified a novel MYCN signature to be highly expressed in H3.3G34R/V tumours. Expression of the H3.3G34R/V mutation in pGBM cells leads to loss of H3K36me3 in cis, and differential genomic binding of the activating mark globally. This appears linked to distinct H3K36me3 enhancer profiles by ChIP-seq, with consistent targeting of lysine 36 demethylases KDM2A/KDM4A. Additional super-enhancers identified in H3G34R/V cells include NOTCH1 and SF3A2, with both Notch signalling and splicing factor gene expression signatures significantly upregulated in patient samples. Screening against a library of >400 chemotherapeutics and small molecules identified a specific dependency for H3.3G34R/V cells on several agents targeting AURKA (as previously linked to MYCN upregulation) but also multiple chemotypes of proteasome inhibitors and the survivin inhibitor YM155. These data identify new rationally-based therapeutic options for exploration in this subset of paediatric/young adult GBM.
Fourier-transform magnetophotoluminescence spectroscopy of donor-bound excitons in GaAs (1994)

High-resolution Fourier-transform photoluminescence spectroscopy combined with the resonant photoexcitation technique was used to study in detail the Zeeman effect on excitons bound to the neutral donors in high purity epitaxial GaAs. The neutral donor g-factor depends on the magnetic-field intensity and orientation in agreement with the predictions of the five-level k\ensuremath{\cdot}p theory. The neutral-donor excited-state energies measured in a range of magnetic field from 0 to 12 T are in an excellent agreement with appropriately scaled calculations for the hydrogen atom. The correspondence between transitions having the same initial state but having as a final state either the nuetral-donor ground state (principal transitions) or a neutral donor excited state (two electron satellites) was established using resonant excitation and was verified by the angular dependences of the peak energies. Linear and circular polarizations of the 2${\mathit{p}}_{\mathrm{\ensuremath{-}}}$, ${2\mathrm{p}}_{0}$, and 2${\mathit{p}}_{+}$ two-electron satellites are consistent with the assignment of zero angular momentum to the ground state of the donor-bound exciton and we show that the transition energies for these components can be calculated with a 0.03-meV accuracy over the range from 0 to 12 T.
Supplementary Data from Tumor Drug Concentration and Phosphoproteomic Profiles After Two Weeks of Treatment With Sunitinib in Patients with Newly Diagnosed Glioblastoma (2023)

Supplementary Data from Tumor Drug Concentration and Phosphoproteomic Profiles After Two Weeks of Treatment With Sunitinib in Patients with Newly Diagnosed Glioblastoma
(Invited) Safe, High-Energy-Density, Solid-State Li Batteries (2018)

We have developed transformational, and intrinsically safe, all-solid-state Li-ion batteries (SSLiBs), by incorporating high conductivity garnet-type solid Li-ion electrolytes into tailored tri-layer microstructures, by low-cost solid oxide fuel cell (SOFC) fabrication techniques to form electrode supported dense thin-film (~10μm) solid-state electrolytes. The microstrucurally tailored porous garnet scaffold support increases electrode/electrolyte interfacial area, overcoming the high impedance typical of planar geometry SSLiBs resulting in an area specific resistance (ASR) of only ~2 to 7 Ωcm -2 at room temperature. The unique garnet scaffold/electrolyte/scaffold structure further allows for charge/discharge of the Li-metal anode and cathode scaffolds by pore-filling, thus providing high depth of discharge ability without mechanical cycling fatigue seen with typical electrodes. Moreover, these scalable multilayer ceramic fabrication techniques, without need for dry rooms or vacuum equipment, provide for dramatically reduced manufacturing cost. Fabrication of supported dense thin-film garnet electrolytes, their ability to cycle Li-metal at high current densities with no dendrite formation, and results for Li-metal anode/garnet-electrolyte based batteries with a number of different cathode chemistries will be presented.
Segmentation morphologique d'images scanners 3D de l'abdomen (2002)

We describe in this paper a segmentation method for 3D CT-scan images of the abdomen based on mathematical morphology.We use a connected operator h-min to reduce the number of regional minima of the gradient image, then we apply the watershed to obtain a mosac image.We obtain a simplified image with large flat-zones that correspond to organs.Rsum.Dans cette communication nous dcrivons une mthode de segmentation pour les images scanners 3D de l'abdomen, fonde sur la morphologie mathmatique.Nous montrons l'utilit d'utiliser un oprateur connexe de type h-min pour rduire le nombre de minima rgionaux de l'image gradient.Nous appliquons ensuite une ligne de partage des eaux pour obtenir une image mosaque.Cette image constitue une simplification de l'image de dpart et contient de larges zones plates qui peuvent correspondre aux organes d'intrt.
Spatial Modeling of Visual Field Data for Assessing Glaucoma Progression (2013)

by using CAR priors, we have modeled the spatial correlation in the eye. combining this with physiologic information, we are able to provide a novel method for VF analysis. model diagnostics, sensitivity, and specificity show our model to be apparently superior to CURRENT POINT-wise linear regression methods. (http://www.anzctr.org.au number, ACTRN12608000274370.).
Transgenic Bt rice lines producing Cry1Ac, Cry2Aa or Cry1Ca have no detrimental effects on Brown Planthopper and Pond Wolf Spider (2017)

Transgenic rice expressing cry genes from the bacterium Bacillus thuringiensis (Bt rice) is highly resistant to lepidopteran pests. The brown planthopper (BPH, Nilaparvata lugens) is the main non-target sap-sucking insect pest of Bt transgenic rice. The pond wolf spider (PWS, Pardosa pseudoannulata) is one of the most dominant predators of BPH in rice fields. Consequently, the safety evaluation of Bt rice on BPH and PWS should be conducted before commercialization. In the current study, two experiments were performed to assess the potential ecological effects of Bt rice on BPH and PWS: (1) a tritrophic experiment to evaluate the transmission of Cry1Ac, Cry2Aa and Cry1Ca protein in the food chain; and (2) binding assays of Cry1Ac, Cry2Aa and Cry1Ca to midgut brush border membrane proteins from BPH and PWS. Trace amounts of the three Cry proteins were detected in BPH feeding on Bt rice cultivars, but only Cry1Ac and Cry2Aa proteins could be transferred to PWS through feeding on BPH. In vitro binding of biotinylated Cry proteins and competition assays in midgut protein vesicles showed weak binding, and ligand blot analysis confirmed the binding specificity. Thus, we inferred that the tested Bt rice varieties have negligible effects on BPH and PWS.
Industrially scalable and cost-effective synthesis of 1,3-cyclopentanediol with furfuryl alcohol from lignocellulose (2016)

A new route for the synthesis of renewable 1,3-cyclopentanediol was developed by rearrangement of furfuryl alcohol to 4-hydroxycyclopent-2-enone followed by hydrogenation.
Androgen receptor pathway inhibitors, prostate cancer, and older adults: a global Young International Society of Geriatric Oncology drug review (2023)

Prostate cancer is a disease of older adults that has undergone a significant therapeutic paradigm shift in the last decade with the emergence of novel androgen receptor pathway inhibitors (ARPis). One of the more commonly used ARPis is enzalutamide. This drug, along with darolutamide and apalutamide, initially received approvals in the metastatic castrate-resistant prostate cancer setting but is now utilized frequently in the metastatic castrate-sensitive and non-metastatic castration-resistant settings. Landmark phase III data illustrating ARPi efficacy in older adults are limited to those with excellent performance status. However, its role in unfit older prostate cancer patients remains to be explored in the context of a narrative review. This first-of-its-kind drug review aims to shed light on the most up-to-date evidence behind the unique toxicity profile of ARPis in the context of geriatric vulnerabilities such as cognitive and functional impairment, along with potential solutions and supporting evidence that exists to circumvent these issues in the vulnerable older adult.
Electro-Absorption Modulator Chirp Profile Influence on DEML Modulation Scheme at 10 Gb/s (2012)

International audience
CD56 Expression Is an Indicator of Poor Clinical Outcome in Patients With Acute Promyelocytic Leukemia Treated With Simultaneous All-Trans-Retinoic Acid and Chemotherapy (2000)

The expression of CD56 is significantly associated with inferior CR duration and survival in patients with APL who were treated with modern frontline treatment that included ATRA and simultaneous chemotherapy. Combined with other well-established prognostic factors such as WBC count, CD56 expression at diagnosis might be used to build prognostic scores for risk-adapted therapy in APL.
The biology of vernix caseosa (2006)

The biology and physical properties of the uniquely human skin cream 'vernix caseosa' are discussed. This material coats the foetal skin surface during the last trimester of gestation and provides multiple beneficial functions for the foetus and newborn infant. Vernix has a complex structure similar to stratum corneum but lacks lipid lamellae and is more plastic due to the absence of desmosomal constraints. In utero, vernix is made in part by foetal sebaceous glands, interacts with pulmonary surfactant, detaches into the amniotic fluid, and is swallowed by the foetus. At the time of birth, vernix has a remarkably constant water content approximating 80%. Postnatally, vernix is simultaneously a cleanser, a moisturizer, an anti-infective, and an anti-oxidant. Vernix facilitates acid mantle development and supports normal bacterial colonization. Its hydrated cellular structure and unusual lipid composition provide a 'best' solution for the needs of the foetus and newborn, not least of which is the attraction of caregivers. Vernix is an important natural biomaterial of potential interest to cosmetic scientists, and other disciplines involved in product development and therapies targeting the complex interface between the stratum corneum and a changing terrestrial environment.
Halostagnicola kamekurae sp. nov., an extremely halophilic archaeon from solar salt (2010)

A novel extremely halophilic archaeon, strain 194-10(T), was isolated from a solar salt sample imported into Japan from the Philippines. Strain 194-10(T) was pleomorphic, neutrophilic and mesophilic and required at least 10 % (w/v) NaCl but no MgSO(4) . 7H(2)O for growth; it exhibited optimal growth at 15 % (w/v) NaCl and 60 mM MgSO(4) . 7H(2)O. Strain 194-10(T) grew at 20-45°C (optimum, 30°C) and pH 6.0-9.0 (optimum, pH 6.5-7.0). The G+C content of its DNA was 59.8 mol%. 16S rRNA gene sequence analysis revealed closest proximity to Halostagnicola larsenii XH-48(T) (98.5 % similarity), the sole representative of the genus Halostagnicola. Polar lipid analysis revealed that strain 194-10(T) contained phosphatidylglycerol and phosphatidylglycerol phosphate methyl ester (the latter derived from both C(20)C(20) and C(20)C(25) archaeol) and several unidentified glycolipids. The results of DNA-DNA hybridization (20.7 % relatedness between Hst. larsenii JCM 13463(T) and strain 194-10(T)) and physiological and biochemical characteristics allowed differentiation of strain 194-10(T) from Hst. larsenii XH-48(T). Therefore, strain 194-10(T) represents a novel species of the genus Halostagnicola, for which the name Halostagnicola kamekurae sp. nov. is proposed, with the type strain 194-10(T) (=DSM 22427(T) =JCM 16110(T) =CECT 7536(T)).
Monitoring Gold Nanorod Synthesis on Surfaces (2004)

We describe a simplified method for the synthesis of gold nanorods on surfaces. Gold colloid seeds were deposited by electrostatic attraction onto silicon wafers and grown in a HAuCl4 solution by surfactant-assisted, seed-mediated synthesis. Microscopic analysis of the nanoparticle ensemble allowed direct observation of several aspects of the anisotropic growth of gold nanorods. Individual seed particles were observed to produce individual nanorods with yields similar to those of previous reports with the seed particles in solution. A minimum seed diameter of 17 nm was required for nanorod nucleation, and this minimum was the same for surfactants with both 12- and 16-carbon chains. However, the chain length affected the isometric seed growth rate, which was faster for the shorter chain surfactant. Altering the surfactant headgroup disrupted the growth anisotropy and produced no nanorods.
Structural transformations in dinuclear zinc complexes involving Zn–Zn bonds (2007)

Reduction of Zn(2)(mu-eta(2)-Me(2)Si(NDipp)(2))(2) with 4 equiv. of KC(8) resulted in a dramatic structural transformation into [(eta(2)-Me(2)Si(NDipp)(2))ZnZn(eta(2)-Me(2)Si(NDipp)(2))](2-) featuring a Zn-Zn bond instead of [Zn(2)(micro-eta(2)-Me(2)Si(NDipp)(2))(2)](2-); the mechanism of the observed structural transformations arising from the Zn-Zn bond formation involving the intermediate of [Zn(2)(mu-eta(2)-Me(2)Si(NDipp)(2))(2)](-) was elucidated by elaborate computations.
Stones (1996)

Division of Urologic Surgery, Department of Surgery and The Comprehensive Kidney Stone Center, Duke University Medical Center, Durham, North Carolina 27710, USA
Chemistry of N-Acetylneuraminic Acid (Neu5Ac) (2004)

シアル酸 (Neu5Ac, Neu5Gc, andKDN) は単糖の中で最も複雑な構造もつ化合物である。シアル酸は分子量320程度の小さな分子にもかかわらず多くの官能基から構成されている。またそれらの官能基が条件によって糖特有の平衡状態とる。このことがシアル酸の合成化学を始めるにあたり難くしている。シアル酸は種々の試薬に大変敏感に反応する性質を持っているので、目的化合物を合成するには経験的な反応条件が必要となる。ここでは、既に報告されている沢山の論文の中からシアル酸の中で最も代表的なN-アセチルノイラミン酸についてNeu5Ac特有の反応と基本的な反応の紹介と、簡単な反応によるNeu5Acの挙動からその化学的な多様性について述べる。
Mechanisms of fluoroquinolone resistance in genetically related strains of Staphylococcus aureus (1997)

Fluoroquinolone resistance in Staphylococcus aureus results from amino acid substitutions at particular locations in the DNA gyrase A and B subunits as well as in the topoisomerase IV A subunit and from NorA-mediated efflux. More than one resistance mechanism may be present in a single strain. Fluoroquinolone-resistant derivatives of SA-1199, a methicillin-susceptible S. aureus strain, were selected in vivo or in vitro, and their mechanisms of fluoroquinolone resistance were identified. We found that many of the resistance mechanisms described above can develop in derivatives of a single parent strain, either singly or in combination, and can arise in a single step. Variances in MICs for strains with the same apparent resistance mechanisms likely are due to the presence of new or undetected but established means of fluoroquinolone resistance. NorA-mediated resistance can occur in the apparent absence of topoisomerase mutations and in some strains may be the result of a promoter region mutation causing increased expression of norA. However, increased expression of norA can occur independently of this mutation, suggesting that a regulatory locus for this gene exists elsewhere on the chromosome.