gebhart/patrepeval huggingface dataset:
Human thimet oligopeptidase (1993)

We have purified human thimet oligopeptidase to homogeneity from erythrocytes, and compared it with the enzyme from rat testis and chicken liver. An antiserum raised against rat thimet oligopeptidase also recognized the human and chicken enzymes, suggesting that the structure of the enzyme has been strongly conserved in evolution. Consistent with this, the properties of the human enzyme were very similar to those for the other species. Thus human thimet oligopeptidase also is a thiol-dependent metallo-oligopeptidase with M(r) about 75,000. Specificity for cleavage of a number of peptides was indistinguishable from that of the rat enzyme, but Ki values for the four potent reversible inhibitors tested were lower. In discussing the results, we consider the determinants of the complex substrate specificity of thimet oligopeptidase. We question whether substrates containing more than 17 amino acid residues are cleaved, as has been suggested. We also point out that the favourable location of a proline residue and a free C-terminus in the substrate may be as important as the hydrophobic residues in the P2, P1 and P3' positions that have been emphasized in the past.
THE UNIFIED MODEL FOR CURRENT-MODE CONTROL: AN ALTERNATIVE DERIVATION (2004)

The two prevalent s-domain models for current-mode control, the continuous-time model and the unified model, exhibit noticeable differences in their small-signal predictions and therefore have become the subject of comparisons and clarifications. The current letter presents an alternative way of deriving the unified model, thereby providing an additional guide for assessing the validity of the unified model. This letter also presents experimental data that support the accuracy of the unified model.
Hybrid Power Pack (Ultra Capacitor + Battery) for Two Wheelers Fitted with Starter Motor (2009)

&lt;div class="htmlview paragraph"&gt;Self-start two-wheelers, including motorcycles and scooters between 50 - 200 cc capacity, use standard lead-acid battery of 5, 9 and 12 Ah rating as energy source. Battery is a well-known energy source but cannot supply large amount of power in short time. The size of the battery is decided based on the starter motor requirement. Deep discharge at the time of cranking reduces the life of the battery drastically as compared to normal use. Extra factor of safety is provided for cold weather cranking performance, poor maintenance and end of life performance in view of deep discharge. Hence it is heavy and bulky. On the other hand, ultracapacitors can supply large burst of power for short time but can not store much energy (hence limited number of starts). It is seen that in Hybrid Power pack (ultracapacitor + down sized Battery) the major power requirement at the time of cranking is taken by ultracapacitor resulting in reduced load on the battery thereby making it possible to be downsized. This paper describes how a Hybrid Power pack utilizes the strengths of both, resulting in a unit which is economical, maintenance free, low in weight with good cold start capability.&lt;/div&gt;
UNSUPERVISED CHANGE DETECTION IN SAR IMAGES USING A MULTICOMPONENT HMC MODEL (2004)

International audience
Self-assembled DNA–cationic-lipid complexes: Two-dimensional smectic ordering, correlations, and interactions (1998)

We report a synchrotron small-angle x-ray scattering (SAXS) study of the mutilayered, self-assembled structure (complex) that is formed by mixing DNA with cationic liposomes. In these complexes the DNA is confined between charged lipid bilayers and orders as a two-dimensional (2D) smectic liquid crystal. The power-law bilayer-bilayer correlations of the 3D multilayer smectic liquid crystal, which are coupled to the 2D lattice of DNA chains, are found to deviate significantly from those described by the standard Caill\'e model of smectic-$A$ phases. To model the DNA ordering, the 2D smectic correlation function and the corresponding structure factor are derived from the smectic Hamiltonian in harmonic approximation. The resulting line shape is then fitted to the DNA correlation peak. It is found that for samples of higher $d,$ short-range correlations between the DNA in adjacent sheets have to be assumed to explain the data. From the least-square fitting, the 2D DNA interchain compressibility modulus $B$ is extracted as a function of $d$ and discussed in view of different possible microscopic interactions responsible for the ordering.
Instance-Aware Image and Sentence Matching with Selective Multimodal LSTM (2017)

Effective image and sentence matching depends on how to well measure their global visual-semantic similarity. Based on the observation that such a global similarity arises from a complex aggregation of multiple local similarities between pairwise instances of image (objects) and sentence (words), we propose a selective multimodal Long Short-Term Memory network (sm-LSTM) for instance-aware image and sentence matching. The sm-LSTM includes a multimodal context-modulated attention scheme at each timestep that can selectively attend to a pair of instances of image and sentence, by predicting pairwise instance-aware saliency maps for image and sentence. For selected pairwise instances, their representations are obtained based on the predicted saliency maps, and then compared to measure their local similarity. By similarly measuring multiple local similarities within a few timesteps, the sm-LSTM sequentially aggregates them with hidden states to obtain a final matching score as the desired global similarity. Extensive experiments show that our model can well match image and sentence with complex content, and achieve the state-of-the-art results on two public benchmark datasets.
[Recreational usage of dextromethorphan--analysis based on internet users experiences]. (2013)

1. DXM is the popular psychoactive substance which has gained a positive opinion among the Internet users. 2. Easy accessibility of DXM may pose a serious threat to health of young people who experiment with psychoactive substances. 3. The improvement of DXM sales control should be considered.
Mixed Self-Assembled Monolayers of Alkanethiolates on Ultrasmooth Gold Do Not Exhibit Contact-Angle Hysteresis (2004)

We present the first study of mixed alkanethiolate SAMs on ultrasmooth gold surfaces. By eliminating surface roughness, it became possible, for the first time, to investigate wetting properties as a function of surface chemical composition. In three different surface compositions, it was found that contact-angle hysteresis apparently vanished. This suggests that surface chemical heterogeneity does not contribute to contact-angle hysteresis in mixed SAMs on ultrasmooth gold surfaces.
Are Spot Freight Rates Stationary? (2006)

In the recent literature, empirical tests of stationarity of freight rates often conclude that spot freight rates are non-stationary processes. However, many maritime economists would argue that the freight rate cannot exhibit asymptotically explosive behaviour, as implied by non-stationarity, in a perfectly competitive freight market. This paper restates the theoretical arguments behind mean reversion and boundedness of the spot freight rate process and suggests that the failure to reject non-stationarity may be due to the weak power of the tests most frequently used. We employ a non-linear version of the Augmented Dickey–Fuller (ADF) test, based on an exponentially smooth-transition autoregressive model (ESTAR). This test enhances the power against mean-reverting nonlinear alternative hypotheses compared to the linear alternative for traditional ADF tests. Our empirical results show, in line with maritime economic theory, that freight rates in both dry-bulk and tanker markets are non-linear stationary.
Integrated Remote Laser Source for 6G Advanced Antenna Systems (2021)

Future generations of mobile communications promise near unlimited access to information and data sharing with ubiquitous wireless connectivity for any kind of device and application that may benefit from being connected. This poses new design challenges and requires a renewal of the hardware platforms to meet the increased demand of capacity and reliability of the network. Next generation Radio Access Network (RAN) will evolve towards an increase of the radio bandwidth, with carrier frequency extended to the millimeter waves (mmW) range. Other technologies that will be extensively used to increase the RAN capacity will be beamforming and spatial multiplexing with advanced antenna systems (AAS) comprising hundreds of antenna elements. Optical technologies are the natural candidates to support the traffic increase, by providing high-capacity interconnection within the radio unit and towards the base band unit (BBU). However, the higher level of integration of AAS will cause an increase of the temperature to values >100°C, due to power dissipation of RF power amplifiers (PA), digital front-end (DFE) and baseband processing Application Specific Circuits (ASIC). This makes the AAS an inhospitable environment for optical transceivers that include lasers, typically operating at temperatures <85°C. A promising approach to solve this issue is to place the laser outside the transceiver as a remote laser source (RLS) in a less harsh environment or in a thermally controlled environment e.g., in the same cabinet of the BBU. In this article we demonstrate a fully integrated RLS enabling a reduction of power consumption and packaging cost.
Evidence for the Presence of Growth Hormone-Releasing Factor In Blood of Hyperglycemic, Hypophysectomized Rats (1966)

SummaryThe IP or IV injection of 3 ml of plasma from hypoglycemic, hypophysecto-mized rats produced a lowering in hypophyse-al growth hormone (GH) on estimation 30 minutes later by the tibial epiphyseal cartilage test for GH. Plasma from untreated or hypoglycemic, intact rats and from untreated hypophysectomized rats was ineffective. No activity was found in plasma from hypogly-cemic, hypophysectomized rats with hypotha-lamic lesions in the ventral pre-mammillary area. The results are interpreted to mean that hypoglycemia results in the appearance of a circulating GH-releasing factor in the blood of hypophysectomized rats.
Ion-Selective Electrodes (1989)

ADVERTISEMENT RETURN TO BOOKPREVChapterNEXTIon-Selective ElectrodesFrom Glasses to Crystals and CrownsJ. D. R. ThomasJ. D. R. ThomasSchool of Chemistry and Applied Chemistry, Redwood Building, University of Wales College of Cardiff, P.O. Box 13, Cardiff CF1 3XF, Wales, United KingdomMore by J. D. R. ThomasDOI: 10.1021/bk-1989-0390.ch021Publication Date (Web):February 7, 2011Publication History Published online7 February 2011Published inprint 1 January 1989Request reuse permissions Copyright © 1989 American Chemical Society. Electrochemistry, Past and PresentChapter 21pp 303-317ACS Symposium SeriesVol. 390ISBN13: 9780841215726eISBN: 9780841225787Chapter Views90Citations-LEARN ABOUT THESE METRICSChapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Electrodes Get e-Alerts
Synthetic atrial natriuretic factor decreases renal tubular phosphate reabsorption in rats (1985)

Atrial natriuretic factor (ANF), a family of peptides isolated from cardiac atria, has marked effects on sodium excretion. A synthetic 26 amino acid sequence of ANF peptide has also been shown to be phosphaturic. However, it is difficult to assess whether the phosphaturia is due to changes in tubular reabsorption of phosphate without control of filtered load of phosphate. In the present study, the hypothesis that ANF peptide decreases tubular phosphate reabsorption was tested by using graded phosphate infusions of 0, 1, 2, and 3 mumol/min in thyroparathyroidectomized rats. Further, reabsorbed phosphate was similarly assessed in rats infused with parathyroid hormone (PTH) to allow comparison with a known phosphaturic hormone. ANF peptide decreased reabsorbed phosphate compared with saline controls (2.72 +/- 0.28 mumol/ml GFR compared with 3.35 +/- 0.35, P less than 0.05) but not as much as a maximally phosphaturic dose of PTH (2.04 +/- 0.13 mumol/ml GFR). We conclude that synthetic ANF peptide decreases tubular phosphate reabsorption in vivo.
Design of a Compact, Multi-Megawatt, Circular TE01 Mode Converter (2006)

Experience gained during the recent operation of high power 11.424 GHz rf sources for accelerators led to new, stricter requirements for system components. One of the basic components of such a system is a mode converter that transforms the rectangular waveguide mode into the TE01 circular waveguide mode. With such a converter, it is possible to minimize the use of WR90 rectangular waveguide which was shown to be a weak part of the previous system at power levels higher than 100 MW and pulse lengths on the order of a microsecond. We used several methods to design a compact mode converter with extremely low parasitic mode conversion. These methods employ HFSS and include multi‐parameter searches, concurrent optimization with a mode‐matching code CASCADE, cascading of resulting S‐matrices, and tolerance analyses. This paper describes the design methods and presents results.
"Para derribar todas las fronteras": un proyecto realizado con inmigrantes latinoamericanos (1998)

La profesora Moyano presenta la labor comunicativa realizada en el marco de Cáritas argentina con grupos de inmigrantes de países del entorno argentino y muestra el interés de este tipo de experiencias.
A Unified 3-D Mobility Model for the Simulation of Submicron MOS Devices (1993)

A calibrated and physically based mobility model is developed for three-dimensional simulation of submicron metal-oxide-semiconductor (MOS) devices, in which the inversion layer mobility is emphasized. This inversion layer mobility can be generalized into a local form, i.e., expressed as functions of the local electric field at each grid point, so that it is well suited for device simulation. The resulting 3-D mobility model accurately characterizes the significant physical scattering effects including the Coulomb screening effect, quantum channel broadening effect, surface roughness scattering, structure-induced lateral surface scattering and velocity saturation limited effects. Results show that this new model can be incorporated into device simulators for accurately predicting drain currents of submicron LDD MOS devices. Moreover, the results compare more favorably with the experimental data than do those for other reported models.
Mitotic Phosphorylation Stimulates DNA Relaxation Activity of Human Topoisomerase I (2008)

Human DNA topoisomerase I (topo I) is an essential mammalian enzyme that regulates DNA supercoiling during transcription and replication. In addition, topo I is specifically targeted by the anticancer compound camptothecin and its derivatives. Previous studies have indicated that topo I is a phosphoprotein and that phosphorylation stimulates its DNA relaxation activity. The locations of most topo I phosphorylation sites have not been identified, preventing a more detailed examination of this modification. To address this issue, mass spectrometry was used to identify four topo I residues that are phosphorylated in intact cells: Ser(10), Ser(21), Ser(112), and Ser(394). Immunoblotting using anti-phosphoepitope antibodies demonstrated that these sites are phosphorylated during mitosis. In vitro kinase assays demonstrated that Ser(10) can be phosphorylated by casein kinase II, Ser(21) can be phosphorylated by protein kinase Calpha, and Ser(112) and Ser(394) can be phosphorylated by Cdk1. When wild type topo I was pulled down from mitotic cells and dephosphorylated with alkaline phosphatase, topo I activity decreased 2-fold. Likewise, topo I polypeptide with all four phosphorylation sites mutated to alanine exhibited 2-fold lower DNA relaxation activity than wild type topo I after isolation from mitotic cells. Further mutational analysis demonstrated that Ser(21) phosphorylation was responsible for this change. Consistent with these results, wild type topo I (but not S21A topo I) exhibited increased sensitivity to camptothecin-induced trapping on DNA during mitosis. Collectively these results indicate that topo I is phosphorylated during mitosis at multiple sites, one of which enhances DNA relaxation activity in vitro and interaction with DNA in cells.
Truly Low Temperature Sintering of Printed Copper Ink Using Formic Acid (2018)

Abstract Low cost electronics are targeted by using solution‐based, upscalable printing technologies, focusing on cost‐efficient materials and additive processes to yield conducting structures with minimal material consumption. Copper nanoparticles (CuNPs) can form the basis for such processes. However, due to the susceptibility of Cu to oxidation, the usual postdeposition treatment methods include expensive and instrumentally elaborate flash lamp and laser sintering approaches. A simple, truly low temperature (130 °C), easy to scale process is reported by using formic acid to sinter structures that are inkjet‐printed using an industrial scale CuNP ink. Electrical conductivity of up to 16% bulk Cu is observed when sintering is carried out at 130 °C and more than 25% bulk Cu conductivity is observed above 150 °C. Four‐point measurements and photoemission spectroscopy detail the formation of a conducting Cu film under the influence of formic acid. Adhesion and bending tests confirm the stability of the thin (&lt;500 nm) printed structures to up to 2% tensile strain. The developed sintering process is specifically targeted for flexible low cost and low temperature compatible plastic substrates such as polyethylene terephthalate. The results underline the suitability of the inkjet process for upscalable Cu electrode production in electronic devices.
Distal Femoral Fixation: A Biomechanical Comparison of the Standard Condylar Buttress Plate, a Locked Buttress Plate, and the 95-Degree Blade Plate (1997)

A condylar buttress plate with locked screws is a valid concept for improving fixation stability.
Toward little heat-affected area of fused silica materials using short pulse and high power CO2 laser (2019)

As a rapid and efficient processing technology, CO2 laser processing has been applied to remove fused silica materials. However, thermal effect caused by CO2 laser would lead to thermal modification layer, thermal deformation and residual stress in processed fused silica optics. To reduce the thermal effect, high power and short pulse CO2 laser is applied to remove the surface material of fused silica. In this work, a model coupling the physical processes of heat transfer and phase transition was established to simulate the complex interaction of CO2 laser with fused silica. Then, the model was applied to investigate the evolutions of temperature distribution and surface morphology involved in the laser ablating and melting processes. The results indicate that with the increase of laser power and decrease of pulse width, positive effect would take place that the radius-depth ratio of ablating area increases and the heat-affected area becomes smaller. For the application of CO2 laser with 0.2 μs pulse width and 800 kW peak power, fused silica material would quickly reach the ablation state. The ablation depth is less than 1 μm, and the thickness of heat-affected area is about 80 nm. It means that the high power and short pulse CO2 laser is equivalent to a hot grinding ball head, which can remove the material rapidly with small heat-affected area on fused silica surface. The simulation results of line scanning processing with CO2 laser were finally compared with the experiment ones, which verified the feasibility of the established model. The suggestions and prospective for improving the model were put forward as well.
Importance of Anterograde Visualization of the Coronary Venous Network by Selective Left Coronary Angiography Prior To Resynchronization (2007)

A coronary angiographical study, including examination of the coronary venous return prior to implantation of a CRT device, can simplify the device implant and allows patient-specific preselection of appropriate tools for the procedure.
Cyclosporine A modifies immune-mediating and therapeutic efficacy of allogeneic perivascular porcine endothelial cell implants (141.51) (2009)

Abstract Non-syngeneic endothelial cell embedded within 3D-matrices (MEEC) when placed in the vascular adventitia control vascular repair processes. Host immunity directed against engrafted allogeneic tissue is a predominant Th1-driven immune response and a major impediment for graft survival. We aimed to identify if cyclosporine A (CsA) would enhance immune compatibility and therapeutic efficacy of allogeneic MEEC. Pigs (n=4/group) underwent balloon injury of both carotid arteries and received a 12 days course of CsA (group 1), perivascular implants of porcine MEEC (group 2), combination of CsA and MEEC (group 3) or were left untreated (group 4). Host immune reactivity was analyzed after 28 and 90 days in 2 pigs/group respectively. No immune reactivity against MEEC was observed in treatment groups 1 and 4. MEEC treatment alone (group 2) induced formation of IgG1 antibodies specific for the allogeneic EC and differentiation of host splenocytes into Th2 but not Th1 cytokine-producing cells. CsA-therapy reduced the frequency of IgG1 antibodies and Th2-cytokine producing splenocytes upon MEEC treatment (group 3). Compared with groups 1 and 4 treatment with MEEC (group 2) significantly inhibited luminal occlusion 28 and 90 days after balloon injury. CsA-treatment reduced the ability of MEEC to inhibit luminal occlusion. MEEC are powerful regulators of vascular injury. MEEC failed to induce a significant Th1-driven allo-immune response but induced differentiation of splenocytes into Th2-cytokine producing cells. This induction and their therapeutic efficacy were alleviated by a 12 day course of CsA. Adventitial MEEC implants -even of allogeneic sources and without immunosuppressive treatment- may be useful in decreasing luminal narrowing in a clinical setting.
A Fully-Differential Complementary Hartley VCO in 0.18 $\mu$m CMOS Technology (2010)

In this letter, a new complementary Hartley (C-Hartley) voltage controlled oscillator (VCO) with fully differential outputs is proposed, in which the self-biasing configuration is introduced to solve the biasing difficulty of a Hartley VCO by employing a five-port transformer. The proposed C-Hartley VCO with the center frequency of 5.6 GHz is implemented in a 1P6M 0.18 μm CMOS process. The measurement result shows that the phase noise is -123.6 dBc/Hz at 1 MHz offset frequency, while dissipating 6.5 mA from 1.6 V supply with the FOM of -188.5 dBc.
Synthesis and CO2/CH4 separation performance of Bio-MOF-1 membranes (2012)

Herein we present the preparation of continuous and reproducible Bio-MOF-1 membranes supported on porous stainless steel tubes. These membranes displayed high CO(2) permeances for equimolar mixtures of CO(2) and CH(4). The observed CO(2)/CH(4) selectivities above one indicate that the separation is promoted by competitive adsorption.