gebhart/patrepeval huggingface dataset:
283 EXPRESSION OF TRANSCRIPTION FACTORS AND MESENCHYMAL DIFFERENTIATION OF STEM CELLS DERIVED FROM WHARTON'S JELLY OF PORCINE UMBILICAL CORD (2007)

Wharton's jelly derived from mesoderm of umbilical cord matrix is an abundant source of stem cells such as mesenchymal and more primitive stem cells that don't raise the ethical issues associated with embryonic stem cells. The Oct-4 POU transcription factor, Nanog , and Sox-2 are expressed in embryonic stem cells and have been implicated in embryonic development and maintenance of pluripotency. The present study examined the expression of early transcription factors, Oct-4 , Nanog , and Sox-2 , and capability of differentiation to osteocytes, adipocytes, and chondrocytes of the cells of Wharton's jelly isolated from porcine umbilical cord. Wharton's jelly was obtained from the umbilical cord of post-natal piglets (immediately after birth). This tissue was diced into 2-mm-diameter explants and attached to tissue culture dishes. Cells were then cultured in DMEM/F12 supplemented with 10% fetal blood serum (FBS), 10 ng mL–1 basic fibroblast growth factor (bFGF), 1 nm dexamethasone, and 10 nm insulin at 38.5°C, 5% CO2 in air. Expression of Oct-4 , Nanog , and Sox-2 by these cells was analyzed by immunocytochemistry and RT-polymerase chain reaction (PCR), and compared with expression by porcine bone marrow MSCs established in our laboratory. Osteogenic, adipogenic, and chondrogenic differentiation were induced following the protocols described earlier (Jin et al . 2007 Int. J. Dev. Biol. 51, 85–90; Mohana Kumar et al . 2007 Mol. Cells, in press). Cells isolated from Wharton's jelly expressed Oct-4 , Nanog , and Sox-2 especially in colonies/clusters, as observed by immunocytochemistry and gene expression by RT-PCR, and this expression was higher than by MSCs isolated from bone marrow. Osteocytes were documented by the formation of the mineral nodules with alkaline phosphatase-positive cells and deposition of calcium. Differentiation into adipocytes was exhibited by oil red O staining of lipid vacuoles. Alcian blue staining for proteoglycans demonstrated the differentiation of chondrogenic cells. In conclusion, the results of the present study suggest that cells isolated from Wharton's jelly have properties of primitive pluripotency and multilineage differentiation. These stem cells, therefore, can serve as an easily accessible and expandable source possessing potential for preclinical applications using a large animal model. This work was supported by Grant No. 20070301034040 from Bio-organ, Republic of Korea .
Secretary treasurer's reports (1977)

article Free Access Share on Secretary treasurer's reports Author: John J. Joyce General Motors Research Labs, Warren, Michigan General Motors Research Labs, Warren, MichiganView Profile Authors Info & Claims ACM SIGMOD RecordVolume 9Issue 1June 1977 pp 3–14https://doi.org/10.1145/984382.984384Published:01 January 1977Publication History 0citation92DownloadsMetricsTotal Citations0Total Downloads92Last 12 Months5Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Trial of Pimavanserin in Dementia-Related Psychosis (2021)

In a trial that was stopped early for efficacy, patients with dementia-related psychosis who had a response to pimavanserin had a lower risk of relapse with continuation of the drug than with discontinuation. Longer and larger trials are required to determine the effects of pimavanserin in dementia-related psychosis. (Funded by Acadia Pharmaceuticals; HARMONY ClinicalTrials.gov number, NCT03325556.).
Catalyst free low temperature direct growth of carbon nanotubes (2005)

A metal catalyst free direct growth process has been developed for the CVD of carbon nanotubes (CNTs) on carbon implanted SiGe islands or Ge dots on Si substrates. From TEM and Raman measurements, the fabricated CNTs are identified as single-walled CNTs (SWNTs) with diameter ranging from 1.2 to 2.1 nm. Essential parts of the substrate preparation after SiGe or Ge dot growth and carbon ion implantation are a chemical oxidation and preheating at 1000/spl deg/C prior to CNT growth. We believe that the lower melting point of Ge and oxidation enhanced surface decomposition assist the formation of carbon clusters.
Bringing Geosciences to K-12 Classrooms: A Teacher Training Program Developed by the Sterling Hill Mining Museum (2019)

Science, Technology, Engineering and Math (STEM) outreach can be provided to many different stakeholders in the education ecosystem. This includes providing STEM training and experiences to teachers that can make a positive impact in the classroom. STEM covers a broad range of technologies and sciences, and one area that can use further support is the geological sciences. This paper discusses a program to aid in bringing the geosciences into the classroom through a teacher training program conducted at the Sterling Hill Mining Museum. A review of geoscience based outreach programs is presented along with a description of the Sterling Hill Mining Museum teacher training program. Key learning objectives are outlined to aid other teachers interested in bringing these materials, skills and knowledge into the classroom. Survey findings are also presented from the teacher participants that were collected pre, post and approximately six months after the program was conducted. With this data examples provided by participants on how these materials were integrated into the classroom are presented. Overall it is hoped that these findings will bring more geoscience into the classroom.
Problems related to the formation of lateral p–n junctions on channeled substrate (100) GaAs for lasers (1988)

We shall describe the main steps required for molecular-beam epitaxial (MBE) growth on structured GaAs substrates for lasers, in particular, a reproducible etching process develolped for GaAs which yields well-defined and controllable tilt angles. The main parameters determining morphology and doping behavior on a facet are tilt angle Θ, substrate temperature, and the V:III ratio. The limiting values of these three parameters for obtaining good quality n- and p-type films, using Si as a dopant, will be determined. We conclude that a (311A) facet is best suited to obtain plane selective doping without generating a detrimental (111A) plane. As a result of this study, lateral p–n junctions with light emission will be demonstrated showing promise for new device structures such as lasers.
Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta‐analysis (2016)

Oocyte donation pregnancies have increased risk of a range of obstetric and neonatal complications.
Finite element simulation of the fatigue behaviour of a MEMS package (2003)

Finite element analysis (FEA) was carried out to analyse the reliability of the solder sealing of a ceramic based vacuum package under the combined effect of atmospheric pressure loading and thermal cycling. The study focused on the effect of cooling history and geometry on the fatigue life of the solder estimated using Engelmaier's correlation involving shear strain range. The fatigue life predictions suggest a very slight effect of atmospheric pressure exerted on the package lid on fatigue life, suggesting that fatigue life is still largely determined by the thermal mismatch between silicon and ceramic. However, fatigue life was found to be significantly affected by the length of time the solder was left to creep before thermal testing, and this is often an overlooked factor in fatigue life estimation. Another interesting result is that the two sides of the package have similar fatigue lives.
Fingerprint classification using convolutional neural networks and ridge orientation images (2017)

Deep learning is currently popular in the field of computer vision and pattern recognition. Deep learning models such as Convolutional Neural Networks (CNNs) have been shown to be extremely effective at solving computer vision problems with state-of-the-art results. This work uses the CNN model to achieve a high degree of accuracy on the problem of fingerprint image classification. It will also be shown that effective image preprocessing can greatly reduce the dimensionality of the problem, allowing fast training times without compromising classification accuracy, even in networks of moderate depth. The proposed approach has achieved 95.9% classification accuracy on the NIST-DB4 dataset with zero sample rejection.
Pdcd2l Promotes Palmitate-Induced Pancreatic Beta-Cell Apoptosis as a FoxO1 Target Gene (2016)

Transcription factor FoxO1 is a key regulator of the insulin-signaling pathway, and is reported to play important roles in pancreatic β cell differentiation, proliferation, apoptosis and stress resistance. The multifunctional nature of FoxO1 is due to its regulation of various downstream targets. Previous studies in our lab identified potential FoxO1 target genes using the ChIP-DSL technique and one of those genes, Pdcd2l, was selected for further study. We found that the expression of Pdcd2l was increased with palmitate treatment; the luciferase assay result revealed that enhanced Pdcd2l promoter activity was responsible for the elevation of Pdcd2l expression. ChIP-PCR was performed to confirm the combination of FoxO1 to Pdcd2l promoter, result showing that FoxO1 could bind to Pdcd2l promoter and this binding was further enhanced after palmitate treatment. Overexpression of FoxO1 significantly induced Pdcd2l promoter activity, leading to increased mRNA level; consistently, interference of FoxO1 abolished the increment of Pdcd2l gene expression triggered by palmitate treatment. In addition, overexpression of Pdcd2l could further increase the percentage of apoptotic cells induced by palmitate incubation, whilst interference of Pdcd2l partially reversed the palmitate-induced apoptosis together with activated Caspase-3, indicating that the latter may play a part in this process. Therefore, in this study, we confirmed the binding of FoxO1 to the Pdcd2l gene promoter and studied the role of Pdcd2l in β cells for the first time. Our results suggested that FoxO1 may exert its activity partially through the regulation of Pdcd2l in palmitate-induced β cell apoptosis and could help to clarify the molecular mechanisms of β cell failure in type 2 diabetes.
Vector-valued image regularization with PDE's: a common framework for different applications (2003)

We address the problem of vector-valued image regularization with variational methods and PDEs. From the study of existing formalisms, we propose a unifying framework based on a very local interpretation of the regularization processes. The resulting equations are then specialized into new regularization PDEs and corresponding numerical schemes that respect the local geometry of vector-valued images. They are finally applied on a wide variety of image processing problems, including color image restoration, in-painting, magnification and flow visualization.
Integrated Management for Hessian Fly in Triticale (1991)

A potential limitation to maximum triticale (× Triticosecale Wittmack) production is severe damage by the Hessian fly ( Mayetiola destructor Say). Effects of planting date, systemic insecticide, and genetic resistance on Hessian fly infestation and yield of triticale were studied in field experiments in the Coastal Plain of Georgia. The experimental design consisted of a split‐split plot arrangement of treatments in a randomized complete block design with four replications. Insecticide treatments were disulfoton (DiSyston 15 G, O,O ‐diethyl S ‐2‐ethylthioethyl phosphorodiothioate) applied in furrow at planting at 1.0 lb a.i./acre and cultivars were: ‘Beagle 82’, ‘Florida 201’, ‘Florico’ (spring types) and ‘Morrison’ (facultative winter type). Hessian fly damage was minimal during the first season, but populations were large and damage was severe during the second season. In both seasons, planting early (October) enhanced fall and winter infestations, whereas planting late (December) avoided fall infestations. Spring‐type cultivars yielded the most in later plantings but yields of Morrison were greatest in earlier plantings. Hessian fly infestations were lower in Morrison than the other cultivars during the fall and winter, which suggests that Morrison exhibits partial resistance to the Hessian fly. Use of disulfoton at planting controlled fall and winter infestation in all plantings but did not affect spring infestations. Insecticide use prevented grain yield losses of spring type cultivars on most planting dates in both seasons. Comparing yield losses (43–292 lb/acre) with an estimated gain threshold indicated that insecticide use may be economically justified for triticale in areas with considerable risk of attack by the Hessian fly.
EXPO: a program for full powder pattern decomposition and crystal structure solution (1999)

EXPO is the integration of two programs, EXTRA and SIRPOW.92 , the first devoted to full powder pattern decomposition and the second to the solution and refinement of crystal structures. The program is able to exploit the prior information obtained during the crystal structure solution process for improving the classical decomposition. EXPO also allows preliminary cycles of Rietveld refinement.
ANF disappearance and tissue distribution in rats (1990)

The disappearance of [125I]atrial natriuretic factor (ANF; Ser99-Tyr126) from the circulation and its tissue distribution with or without nonlabeled ANF pretreatment were investigated in normotensive Sprague-Dawley rats. Preadministration of the cold peptide increased plasma radioactivity levels for over 8 min following labeled ANF injection but did not change the half-life of circulating labeled ANF. The metabolic clearance rate (MCR) and volume of distribution in the first, second, and steady state phase were significantly decreased after cold ANF pretreatment. Circulating iodo-labeled ANF was taken up by several organs, even by tissues such as fat or bone, but its urinary excretion was very low. The highest uptake was found in the liver (16 +/- 1% of the injected dose), lung (14 +/- 1%), and kidney (12 +/- 1%), diminishing by 21, 89, and 59%, respectively, after cold ANF preinjection. The brain radioactivity was negligible implying an inability of [125I]ANF to cross the blood-brain barrier. Our data underscore the importance of the uptake-mediated, cold ANF preadministration suppressible clearance of ANF from the circulation, probably one of its basic elimination mechanisms. The liver, lung, and kidney are probably the most important participants in the MCR of ANF.
Gold-catalyzed synthesis of N,O-heterocycles (2010)

The selective synthesis of oxazoles, alkylidene oxazoles, and 1,3-oxazines from N -propargyl carboxamides by choosing gold(III) or gold(I) catalysts and selecting terminal or internal alkynes as substrates is discussed. The mechanistic studies based on labeling experiments and intensive in situ NMR studies indicate an anti -oxyauration step and a proto-deauration with retention of the sterical arrangement at the double bond. The synthetic scope for gold(I) catalysts is very broad, allowing selective conversions to products with properties of chelate ligands, reactions of bromoarenes and the formation of acceptor-substituted oxazoles. With N -heterocyclic carbene (NHC) ligands in the presence of a base, even the vinylgold intermediates of the reactions leading to 1,3-oxazines could be isolated, a reaction with a great potential for future mechanistic studies and future applications of gold catalysis.
Reconfigurable Multifunctional Operation Using Optical Injection-Locked Vertical-Cavity Surface-Emitting Lasers (2009)

In this paper, we extend the system application of optical injection-locked (OIL) vertical-cavity surface-emitting lasers (VCSELs) to future optical networks by realizing multifunctional operation using a filter-assisted OIL-VCSEL scheme that can be reconfigured. By using a single chirp-adjustable injection-locked VCSEL (either single mode or multimode) followed by a tunable delay line interferometer, we experimentally demonstrate three functions, showing ultra-wide band (UWB) monocycle generation, nonreturn-to-zero (NRZ) to pseudoreturn-to-zero (PRZ) data format conversion, and NRZ-data clock recovery at 10 Gb/s.
Monte Carlo Calculation of Noise Near the Potential Minimum of a High-Frequency Diode (1956)

Noise near the potential-minimum of a high-frequency diode has been calculated in this paper using a high speed electronic, digital computer. Random numbers were generated and used to simulate the emission of electrons at the cathode. Electrons emitted were continuously fed into the calculating process and those collected on the anode or returned to the cathode were automatically erased. In this way the electron motions computed by numerical integration followed the actual operation of a one-dimensional space-charge limited diode. The results of this paper are based upon data obtained in the course of 3000 unit time intervals. In each case current and velocity fluctuations near the potential minimum were computed. This basic information permitted the calculation of the reduction in noise current caused by space-charge smoothing. The results were then applied for a calculation of the minimum noise figure for microwave beam-type amplifiers and show a sharp minimum of less than 2 db around 2500 Mc and a maximum of about 7.5 db near 4000 Mc. At very low frequencies the noise figure is small and agrees with existing low-frequency theories. At very high frequencies it approaches the figure corresponding to full shot noise, namely 6.3 db. Within the accuracy of calculation, correlation between current and velocity fluctuations has not been found nor the smoothing in velocity fluctuation.
A Large Scale Study of Web Service Vulnerabilities (2015)

The pervasiveness of Web Services, compounded with seamless interoperability characteristics, introduces security concerns that are to be carefully considered with the envisioned internet architecture. In this paper, we propose a comprehensive study on Web Service vulnerabilities. We consider not only well known Web-based vulnerabilities such as SQL injection, session replay etc, but we also analyze Web-Service specific vulnerabilities and their potential of attacks due to poor service construction and lack of service maintenance. In our analysis, we classify each of the studied vulnerability according to a new taxonomy, discuss remedies and impact, and propose methods of detection based on real-time analysis. Our analysis is supported by the results of a large scale study involving over 2,000 real-world Web Services. Finally, we leverage our empirical finding by introducing a proxy-based solution that shields services and clients from any possible attacks.
Minimisation of circuit complexity of step-up/down three-phase AC to DC converter with sinusoidal input current and unity power factor (1995)

The authors present a three-phase step-up/down AC/DC power converter with minimised circuit complexity while achieving both sinusoidal input curent and unity power factor. Although at the cost of higher rated power and complexity of the coupling inductors, the proposed circuit requires only one active switch and provides proper transformation ratio for matching the input and output voltage levels as well as multiple outputs. Further analysis and design work is necessary in reducing the current peak and voltage stress to make this circuit more practical for high power applications.
Supplementary Data from Gene Expression Profiles Classify Human Osteosarcoma Xenografts According to Sensitivity to Doxorubicin, Cisplatin, and Ifosfamide (2023)

Supplementary Data from Gene Expression Profiles Classify Human Osteosarcoma Xenografts According to Sensitivity to Doxorubicin, Cisplatin, and Ifosfamide
Free Radical Induced Acceleration of Cationic Photopolymerization (1998)

Two new monomers based on α-terpineol were prepared, allyl α−terpineol ether epoxide (III) and 1-propenyl ether α-terpineol epoxide (IV). The photoinitiated cationic polymerizations of these two monomers as well as two model compounds, 1-propenyl α-terpineol ether and methyl α-terpineol ether epoxide, were studied using real-time infrared spectroscopy. Surprisingly, the rates of epoxide ring-opening polymerization of both monomers were greatly enhanced as compared to the model compounds. At the same time, the rate of polymerization of the 1-propenyl ether groups in IV was depressed. Two different mechanisms which involve the free radical induced decomposition of the diaryliodonium salt photoinitiator were proposed to explain the rate acceleration effects.
ReproLite (2014)

Cloud systems have become ubiquitous today -- they are used to store and process the tremendous amounts of data being generated by Internet users. These systems run on hundreds of commodity machines, and have a huge amount of non-determinism (thousands of threads and hundreds of processes) in their execution. Therefore, bugs that occur in cloud systems are hard to understand, reproduce, and fix. The state-of-the-art of debugging in the industry is to log messages during execution, and refer to those messages later in case of errors. In ReproLite, we augment the already widespread process of debugging using logs by enabling testers to quickly and easily specify the conjectures that they form regarding the cause of an error (or bug) from execution logs, and to also automatically validate those conjectures.
Brown Hairy Patch on Trunk (2015)

Teledermatology is a term to describe the provision of dermatologic medical services through telecommunication technology. In this modality, there is transfer of medical information electronically (e.g., clinical history and visual data) on a patient in one location to a provider who is in another location. The construct of this column is such that cases are presented in a standardized teledermatology reader format. This is a case of a brown hair-bearing patch presenting on the trunk.
Fiber‐post bond strength in canals obturated with a cross‐linked gutta‐percha core obturator (2014)

The aim of this in-vitro study was to evaluate the bond strength of fiber posts cemented in a root canal filled using various root-canal obturation techniques. A total of 33 monoradicular samples, treated endodontically, were randomly assigned to three groups according to the root-canal obturation technique: group 1, continuous-wave technique; group 2, plastic-obturator-core technique; and group 3, cross-linked gutta-percha obturator-core technique. Fiber posts were luted in each sample and each was sectioned perpendicular to the post axis. The push-out test was performed using a universal machine and the maximum failure load was recorded in MPa mm(-2) . Several samples were randomly chosen for scanning electron microscopy evaluation. The mean debris and dentinal tubule-opening scores were calculated separately in the coronal and apical portions. Bond strength was significantly higher in group 1 than in groups 2 and 3. Debris scores were significantly higher in the apical portion of groups 2 and 3 than in group 1. Within the limitations of this study it can be affirmed that thermoplasticized alpha gutta-percha seemed to worsen the cleaning of post-space walls and hence reduced fiber-post bond strength.