gebhart/patrepeval huggingface dataset:
15N NMR spectroscopy 28—solvent effects on the 15N13C coupling constants of amides, imides, ureas and polypeptides (1980)

Abstract The 15 N 13 C coupling constants of 15 N‐enriched acetamide, N ‐acetylglycine anilide, phthalimide, α,α′‐bisphthalimido‐ p ‐xylene, N ‐methyl‐ N ′‐phenylurea, poly‐ L ‐alanine and poly‐ L ‐valine were measured in various solvents. It was found that the 15 N 13 C coupling constants depend largely on the nature of the solvent. Increasing acidity leads to higher one‐bond and lower two‐bond coupling constants. A change of concentration does not have any influence on the 15 N 13 C couplings while a large increase in temperature leads to a slightly lower 1 J (NC). It is concluded that solvent effects may limit the use of 15 N 13 C coupling constants for the elucidation of solvent‐induced conformational changes.
Der erste klinische Einsatz einer dynamischen (Nach-) Registrierung für die Navigation in der FESS (2012)

The first clinical study for use of an automatic algorithm for recognition and reduction of faulty registration of a CT, navigation was successful. The findings suggest that by using automatic intraoperative registration DRS consisting inaccuracy can be reduced. In practice this means an efficient quality improvement of the Navigation.
Electroremediation:  Removal of Heavy Metals from Soils by Using Cation Selective Membrane (1998)

When the electroremediation is used to remove heavy metals from soils, metals may precipitate as hydroxides near the cathode where the pH is raised, which limits the remediation efficiency. The pH rise is caused by the genera tion of hydroxyl ions as a result of cathodic hydrogen evolution reaction during the remediation. In previous studies, a method to deal with the pH impact was developed. In the method, to prevent the transport of the hydroxyl ions into the soil being treated, a length of tube filled with solution and containing no soil is placed between the cathode and the soil. The heavy metals can then preciptate in the water instead of in the soil. In this study, a new method is proposed and developed. A cation selective membrane is placed in front of the cathode to stop the advancement of hydroxyl front toward the anode. This can considerably reduce the water volume needed, while ensuring that the soil being treated is at low pH condition. Thus, metal precipitation could not occur in the soil and heavy metals may migrate out of the soil, and precipitate in the water. Some unexpected phenomena were encounted and solved. Bench-scale experiments have been conducted to remove copper from sand by the method. The experimental results show that a removal efficiency higher than 90% can be reached.
Risk Factors for Nipah Virus Infection among Abattoir Workers in Singapore (2000)

During 10-19 March 1999, 11 workers in 1 of 2 Singaporean abattoirs developed Nipah-virus associated encephalitis or pneumonia, resulting in 1 fatality. A case-control study was conducted to determine occupational risk factors for infection. Case patients were abattoir A workers who had anti-Nipah IgM antibodies; control subjects were randomly selected abattoir A workers who tested negative for anti-Nipah IgM. All 13 case patients versus 26 (63%) of 41 control subjects reported contact with live pigs (P=.01). Swine importation from Malaysian states concurrently experiencing a Nipah virus outbreak was banned on 3 March 1999; on 19 March 1999, importation of Malaysian pigs was banned, and abattoirs were closed. No unusual illnesses among pigs processed during February-March were reported. Contact with live pigs appeared to be the most important risk factor for human Nipah virus infection. Direct contact with live, potentially infected pigs should be minimized to prevent transmission of this potentially fatal zoonosis to humans.
Supplementary Video 7 from Iodide Transporter NIS Regulates Cancer Cell Motility and Invasiveness by Interacting with the Rho Guanine Nucleotide Exchange Factor LARG (2023)

&lt;p&gt;MOV file - 3MB, Time lapse video microscopy of Hek293 cells stably expressing NISwt and transfected with siRNA scrumble&lt;/p&gt;
A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naive Adults (2020)

NCT03162614.
Low-Profile Highly Directive 2D-Beam-Steering Antenna in Ka-band with 3D-printed All-dielectric Sub-wavelength Deflectors (2022)

An elegant combination of a large-aperture planar radiating panel and a 2D-scanning part, implemented through a pair of 3D-printed sub-wavelength deflectors, is presented in this paper to demonstrate a low-profile 2D-scanning antenna system in Ka-band. A 28-cm-diameter prototype was manufactured, with in particular the dielectric deflectors fabricated by 3D printing of a high-permittivity and low-loss composite. The total height of the antenna system is only 4 cm, corresponding to 3.8 wavelengths at 29 GHz. The antenna system demonstrates a steering capacity up to 66° in elevation and 360° in azimuth, with a measured realized gain of 33 dBi at 0° and 27.4 dBi at 66° scan angle at 29 GHz. The 3dB-bandwidth is 6.5%, covering the 27.75-29.6GHz range. The measured results validate the simulated steering performance of the system with good agreement and confirm the advantage of using this concept for achieving low-cost, low-profile, lightweight, and simple-configuration 2D-beam-scanning antenna.
Synthesis of 1‐Aryl‐1H‐pyrazolecarbonitriles and related derivatives (1988)

Abstract The synthesis of 1‐aryl‐5‐cyano‐1 H ‐pyrazole‐4‐carboxylic acid, ethyl esters 1 is described. Subsequent chemistry led to relatively simple and unique pyrazole derivatives. Most important of these are 1‐aryl‐5‐(aminocarbonyl)‐1 H ‐pyrazole‐4‐carboxylic acids 2, which are chemical hybridizing agents in wheat and barley. The regioselective hydrolysis of 1‐(3‐chlorophenyl)‐1 H ‐pyrazole‐4,5‐dicarboxylic acid, dimethyl ester (7b) and subsequent chemistry is also described.
MLAA-based RF surface coil attenuation estimation in hybrid PET/MR imaging (2017)

Attenuation correction (AC) for both patient and hardware attenuation of the 511 keV annihilation photons is required for accurate PET quantification. In hybrid PET/MR imaging, AC for stationary hardware components such as patient table and MR head coil is performed using CT{derived attenuation templates. AC for flexible hardware components such as MR radiofrequency (RF) surface coils is more challenging. Registration{based approaches, aligning scaled CT{derived attenuation templates with the current patient position, have been proposed but are not used in clinical routine. Ignoring RF coil attenuation has been shown to result in regional activity underestimation values of up to 18 %. We propose to employ a modified version of the maximum{ likelihood reconstruction of attenuation and activity (MLAA) algorithm to obtain an estimate of the RF coil attenuation. Starting with an initial attenuation map not including the RF coil, the attenuation update of MLAA is applied outside the body outline only, allowing to estimate RF coil attenuation without changing the patient attenuation map. Hence, the proposed method is referred to as external MLAA (xMLAA). In this work, xMLAA for RF surface coil attenuation estimation is investigated using phantom and patient data acquired with a Siemens Biograph mMR. For the phantom data, average activity errors compared to the ground truth was reduced from -8:1% to +0:8% when using the proposed method. Patient data revealed an average activity underestimation of -6:1% for the abdominal region and -5:3% for the thoracic region when ignoring RF coil attenuation.
Resting metabolic rate: a critical, primary care screening test. (2006)

Dear Readers,

At the time of this Webcast recording, I had no idea that a leading manufacturer of handheld indirect calorimeters, HealtheTech in Golden, Colorado, was about to announce its dissolution! I am deeply dismayed by this news, as it seems to be a setback for this very helpful technology. If anyone out there has knowledge of an alternate source of equally precise, handheld RMR devices, please do share.

Warm Regards,

Val Jones, MD, MA

AJuly 05, 2005






Download video file.(19M, mp4)




As the ‘diabesity’ epidemic rages on, 95% of all diets fail, and two thirds of Americans are either overweight or obese.[1,2] All kinds of reasons have been cited for the rise of obesity, yet there is a critical component of the weight management equation that has not received much attention: resting metabolic rate or “RMR.”

Many dieters assume that they have slow metabolisms and must starve themselves to lose any weight at all. In fact, the opposite is true in many cases: Dieters can have fairly hefty caloric needs, and undercutting themselves by more than 500 calories per day will cause undue hunger and drastically decrease diet adherence.[3]

In an ongoing study of obese New Yorkers, resting metabolic rates among women of equal ages and body mass indexes varied by as much as 700 calories a day, and men by as much as 1000 calories a day.[4] This suggests very strongly that “one diet does not fit all.” Moreover, attempts to predict a patient's metabolic rate with the Harris-Benedict equation, among others, often yields inaccurate results.[5,6]

Resting metabolic rate measurement is easier than ever, as handheld devices have replaced the cumbersome “metabolic carts” of exercise physiology labs.[7] Indirect calorimeters measure oxygen consumption (VO2) to determine RMR by means of a 5- to 10-minute breath test. The cost to consumer is perhaps $20 a test, and since RMR represents about 75% to 80% of daily caloric needs, it is fairly easy to calculate an appropriate calorie target for weight loss, taking into account general activity levels.[3]

I think that RMR should be part of regular screening performed by primary care physicians and healthcare professionals involved in assisting patients with weight loss. Dieting without an individualized caloric goal is like driving a car without a steering wheel. Maybe this is part of the reason why America has so many “nutritional casualties?”

That's my opinion and I'd like to hear yours. I'm Dr. Val Jones, Editor of MedGenMed's eSection on Clinical Nutrition & Obesity.

Sign Up now for a free monthly email that brings you the top features from MedGenMed.

Readers are encouraged to respond to George Lundberg, MD, Editor of MedGenMed, for the editor's eyes only or for possible publication via email: ten.epacsdem@grebdnulg
Identification, cloning and expression of Pseudomonas aeruginosa Ps-x putative urate oxidase gene in Escherichia coli. (2004)

In a previous study we reported for the first time the isolation and characterization ofurate oxidase enzyme from Pseudomonas aeruginosa. In this work we isolated and cloned a 1.350 kilobase DNA fragment that encode a putative urate oxidase gene from the genomic library of P. aeruginosa Ps-x. The nucleotide sequence of the cloned DNA insert revealed an open reading frame that encodes a protein of a molecular weight of 54.0 kDa. The cloned DNA fragment showed an uricolytic activity when expressed in E. coli DH5alpha. Surprisingly, the nucleotide sequence of the cloned gene showed more than 99% identity to the gene encoding hypothetical protein of P. aeruginosa PAO1. Moreover, the sequence of the cloned gene was closely similar to the corresponding uricase gene of Cellulomonas flavigena (44% similarity), but showed lower similarity values to that of Bacillus sp. BT-90 (24% similarity), Candida utilis (24% similarity). Interestingly, the isolated uricase gene showed closer similarity to uricase from yeast-like symbiotic fungi Beauveria bassiana (35%), Tolypocladium inflatum (29%), Paecilomyces tenuipes (27%) and Cerataphis fransseni (24%).
Objective metrics of patient activity: Use of wearable trackers and patient reported outcomes in predicting unexpected healthcare events in cancer patients undergoing highly emetogenic chemotherapy. (2018)

6519 Background: Functional status and predictors that identify those cancer patients at risk for unplanned hospitalization can have broad implications for the health care system and clinical trials. We evaluated the feasibility of monitoring physical activity (PA) using wearable activity trackers in cancer patients on highly emetogenic chemo as well as potential correlations between PA and unplanned healthcare events (UHE) and ECOG scores. Methods: This study was conducted as a multi-institutional single arm observational clinical trial of 65 patients with solid tumors undergoing highly emetogenic chemo based on Hesketh classification. We measured PA by analyzing daytime hourly metabolic equivalents (1 MET = resting metabolic rate) from 10 AM - 7 PM over 60 days via Microsoft band 2. Patient reported outcome data was collected using smartphone apps. UHE were collected by review of medical records over the 60 days of band wear plus 90 days of clinical follow up. Results: Data was successfully captured from 41 of the 65 activity trackers. Patients were compliant with wearing the activity trackers for > 7 of 9 total hrs on 67.7% of study days. Only 9 out of 41 patients exhibited > 60 hours of non-sedentary activity, defined as > 1.5 METs, over the 60-day band wear period. Mean step counts/day were similar between higher and lower PA groups at 2564 steps/d and 2261 steps/d respectively. 9 patients with > 60 hrs of 1.5 METs had significantly fewer UHE compared to the 32 patients with < 60 hrs of 1.5 METs (p = 0.02). The physician reported ECOG scores had no correlation with PA or UHE. Conclusions: In solid tumor patients undergoing highly emetogenic chemo regimens, activity trackers are feasible and identify those patients with a profile of lower activity that predicts UHE. Incorporation of activity trackers has the potential to identify patients who are at need for interventions to prevent hospitalization and may also predict the subset of patients enrolled in clinical trials who are more likely to record serious adverse events.
Phosphorus Recovery in Surface Runoff from Swine Lagoon Effluent by Overland Flow (1997)

Abstract A study was conducted in Alabama to determine P removal by overland flow of swine lagoon effluent on bermudagrass ( Cynodon dactylon L.‘Russell’) and annual ryegrass ( Lolium multiflorum Lam). Treatments included ammonium nitrate at 560 kg N ha −1 yr −1 , three rates of lagoon effluent which provided 560, 1120, and 2240 kg N ha −1 yr −1 and 71, 142, and 284 kg P ha −1 yr −1 , respectively, and a control. Experiments were conducted at 5 and 10% slopes on a Marvyn loamy sand (fine‐loamy, siliceous, thermic Typic Kanhapludults). The length of slope from application site to collection site was 6.1 m. Surface runoff was collected and sampled monthly for dissolved and sediment P. The results indicated that higher concentrations of P were found during the early spring and summer seasons when treatments were applied. Concentrations of dissolved P and total P exceeded critical values associated with accelerated eutrophication. No significant differences were found for sediment P concentrations on either 5 or 10% slopes for any of the three rates of P application. Phosphorus applications did not significantly affect dissolved P concentrations on the 5% slope, but there were significant treatment effects for dissolved P concentrations on the 10% slope. Slope did not significantly affect dissolved P concentration but significantly affected sediment P concentration. Total P mass losses in surface runoff were &lt;0.6 kg P ha −1 on the 5% slope and 1.0 kg P ha −1 on the 10% slope during the research period.
Design and Testing of a Wireless Portable Carbon Nanotube-Based Chemical Sensor System (2006)

The design and preliminary testing results of a wireless portable carbon nanotube-based chemical sensor system are presented in this paper. The overall sensor system consists of a chemical sensor module, a microcontroller-based data acquisition module, a multiplexer and constant current source module, and a wireless communication module. The chemical sensor module is based on use of an interdigited electrode (IDE) configuration. A layer of single-walled carbon nanotubes (SWNTs) is laid on the IDE electrodes. Chemical sensing is based on detection of changes in the conductivity of the SWNT network. The system has 32 channels of chemical sensing elements. It is self-contained and portable, and wirelessly transmits measurement data to a PC via an 802.11b wireless LAN. Preliminary results on chemical detection and chemical selectivity are described.
Human gesture recognition using Kinect camera (2012)

In this paper, we propose a comparison of human gesture recognition using data mining classification methods in video streaming. In particular, we are interested in a specific stream of vector of twenty body-joint positions which are representative of the human body captured by Kinect camera. The recognized gesture patterns of the study are stand, sit down, and lie down. Classification methods chosen for comparison study are backpropagation neural network, support vector machine, decision tree, and naive Bayes. Experimental results have shown that the backpropagation neural network method outperforms other classification methods and can achieve recognition with 100% accuracy. Moreover, the average accuracy of all classification methods used in this study is 93.72%, which confirms the high potential of using the Kinect camera in human body recognition applications. Our future work will use the knowledge obtained from these classifiers in time series analysis of gesture sequence for detecting fall motion in a smart home system.
Cardiovascular effect of epinephrine in endodontic microsurgery: a review (2013)

Epinephrine is one of the most widely-used vasoconstrictors in dental treatment including endodontic microsurgery. However, the systemic safety of epinephrine has been in debate for many years because of its potential risk to cause cardiovascular complications. The purpose of this review was to assess the cardiovascular effect of epinephrine use in endodontic microsurgery. Endodontic microsurgery directly applies epinephrine into the bone cavity, and the amount is reported to be much larger than other dental surgeries. Moreover, when considering that systemic potency of intraosseous application is reported to be comparable to intravenous application, the systemic influence of epinephrine could be increased in endodontic microsurgery. Besides, pre-existing cardiovascular complications or drug interactions can enhance its systemic influence, resulting in increased susceptibility to cardiovascular complications. Although clinical studies have not reported significant complications for patients without severe systemic complications, many epinephrine-induced emergency cases are warning the cardiovascular risk related with pre-existing systemic disease or drug interactions. Epinephrine is a dose-sensitive drug, and its hypersensitivity reaction can be fatal to patients when it is related to cardiovascular complications. Therefore, clinicians should recognize the risk, and the usage of pre-operative patient evaluation, dose control and patient monitoring are required to ensure patient's safety during endodontic microsurgery.
TECHNICAL NOTE: Estimating beef-cattle forage demand: Evaluating the animal unit concept (2012)

The objective of this experiment was to evaluate the effect of BW and physiological status of a beef animal on forage intake. The experiment was repeated over 2 yr with 6 replications of 3 treatments per year: cow-calf pair (CCP, BW = 629 kg), nonlactating cow (NLC, BW = 503 kg), and yearling steer (YS, BW = 305 kg). The CCP was treated as one unit, with the sum of cow BW and calf BW comprising CCP BW. Calves averaged 42 d of age and 73 kg at the start of the experiment each year. Animals were housed in individual pens and fed grass hay harvested from subirrigated meadow (11% CP) in quantities sufficient for ad libitum intake. Intake of DM, OM, DM that disappeared in vitro, and NDF were greatest (P < 0.01) for CCP, intermediate for NLC, and least for YS. As a percentage of BW, the CCP had greater (P < 0.01) intake of DM, OM, DM that disappeared in vitro, and NDF than did both the NLC and YS, which were not different (P > 0.05) from each other. When expressed as a percentage of metabolic BW (BW0.75), intake of DM, OM, DM that disappeared in vitro, and NDF were greatest (P < 0.01) for CCP, intermediate for NLC, and least for YS. Results indicate that intake differences among cattle of different physiological states should be considered when calculating forage demand for stocking rate or feeding purposes.
Stromal-Based Signatures for the Classification of Gastric Cancer (2016)

Treatment of metastatic gastric cancer typically involves chemotherapy and monoclonal antibodies targeting HER2 (ERBB2) and VEGFR2 (KDR). However, reliable methods to identify patients who would benefit most from a combination of treatment modalities targeting the tumor stroma, including new immunotherapy approaches, are still lacking. Therefore, we integrated a mouse model of stromal activation and gastric cancer genomic information to identify gene expression signatures that may inform treatment strategies. We generated a mouse model in which VEGF-A is expressed via adenovirus, enabling a stromal response marked by immune infiltration and angiogenesis at the injection site, and identified distinct stromal gene expression signatures. With these data, we designed multiplexed IHC assays that were applied to human primary gastric tumors and classified each tumor to a dominant stromal phenotype representative of the vascular and immune diversity found in gastric cancer. We also refined the stromal gene signatures and explored their relation to the dominant patient phenotypes identified by recent large-scale studies of gastric cancer genomics (The Cancer Genome Atlas and Asian Cancer Research Group), revealing four distinct stromal phenotypes. Collectively, these findings suggest that a genomics-based systems approach focused on the tumor stroma can be used to discover putative predictive biomarkers of treatment response, especially to antiangiogenesis agents and immunotherapy, thus offering an opportunity to improve patient stratification. Cancer Res; 76(9); 2573-86. ©2016 AACR.
Chemoinformatics : concepts, methods, and tools for drug discovery (2004)

In the post-genomic era, the role informatics technologies plays in chemical and pharmaceutical research has become increasingly important in data management and lead-compound identification. In Chemoinformatics: Concepts, Methods, and Tools for Drug Discovery, well-recognized pioneers and investigators from diverse professional environments survey the key concepts in the field, describe cutting-edge methods, and provide exemplary pharmaceutical applications. The authors explain the theory behind the crucial concepts of molecular similarity and diversity, describe the challenging efforts to use chemoinformatics approaches to virtual and high-throughput screening, and illuminate the latest developments in multidimensional QSAR analysis. Other topics of interest include the use of partitioning algorithms and classification methods for analyzing large compound databases, screening sets, and virtual screening for active molecules; different approaches to target class-specific library design; the generation of novel classes of molecular descriptors; and Web-based tools for chemical database access and management. Also presented are different methods for describing molecular chirality and conformational parameters and for predicting the drug-like character and basic ADME properties of compounds based on modeling their putative interactions with cytochrome P450 isoforms. State-of-the-art and user-friendly, Chemoinformatics: Concepts, Methods, and Tools for Drug Discovery illuminates the conceptual and methodological diversity of this rapidly evolving field and offers instructive examples of cutting-edge applications in the drug discovery process