gebhart/patrepeval huggingface dataset:
Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit (2004)

Serotonin (5-HT) modulates synaptic efficacy in the nervous system of vertebrates and invertebrates. In the nematode Caenorhabditis elegans, many behaviors are regulated by 5-HT levels, which are in turn regulated by the presence or absence of food. Here, we show that both food and 5-HT signaling modulate chemosensory avoidance response of octanol in C. elegans, and that this modulation is both rapid and reversible. Sensitivity to octanol is decreased when animals are off food or when 5-HT levels are decreased; conversely, sensitivity is increased when animals are on food or have increased 5-HT signaling. Laser microsurgery and behavioral experiments reveal that sensory input from different subsets of octanol-sensing neurons is selectively used, depending on stimulus strength, feeding status, and 5-HT levels. 5-HT directly targets at least one pair of sensory neurons, and 5-HT signaling requires the Galpha protein GPA-11. Glutamatergic signaling is required for response to octanol, and the GLR-1 glutamate receptor plays an important role in behavioral response off food but not on food. Our results demonstrate that 5-HT modulation of neuronal activity via G protein signaling underlies behavioral plasticity by rapidly altering the functional circuitry of a chemosensory circuit.
The Neurobiology of Opiate Reinforcement (1998)

This article provides a basic introduction into two commonly used behavioral paradigms used for the assessment of the reinforcing and rewarding effects of drugs in experimental animals. Behavioral as well as neurochemical data regarding the neural basis of opiate reward are then critically reviewed in order to evaluate the neuroanatomical and neurochemical substrates mediating the primary and conditioned reinforcing effects of opiates as well as current hypotheses of drug-induced reward and aversion.
Oral Contraceptives for Dysmenorrhea in Adolescent Girls (2005)

In Brief Objective: To assess whether a low-dose oral contraceptive (OC) is more effective than placebo treatment for dysmenorrhea pain in adolescents. Methods: This was a randomized, double-blind, placebo-controlled clinical trial of 76 healthy adolescents aged 19 years or younger reporting moderate or severe dysmenorrhea. Subjects were randomly allocated to receive either an OC (ethinyl estradiol [E2] 20 μg and levonorgestrel 100 μg) or a matching placebo for 3 months. Participants used their usual pain medications as needed during the trial. The main outcome measure was score on the Moos Menstrual Distress Questionnaire (pain subscale) for the third menstrual cycle on treatment. Secondary outcomes included pain intensity (rated 0 to 10), days of any pain, days of severe pain, hours of pain on worst day, and use of pain medications. Results: The mean Moos Menstrual Distress Questionnaire pain score was lower (less pain) in the OC group than the placebo group (3.1, standard deviation 3.2 compared with 5.8, standard deviation 4.5, P = .004, 95% confidence interval for the difference between means 0.88–4.53). By cycle 3, OC users rated their worst pain as less (mean pain rating 3.7 compared with 5.4, P = .02) and used fewer pain medications than placebo users (mean pain pills used 1.3 compared with 3.7, P = .05). By cycle 3, OC users reported fewer days of any pain, fewer days of severe pain, and fewer hours of pain on the worst pain day than placebo users; however, these differences did not reach statistical significance. Conclusions: Among adolescents, a low-dose oral contraceptive relieved dysmenorrhea-associated pain more effectively than placebo. Level of Evidence: I Oral contraceptives are more effective than placebo treatment for relieving dysmenorrhea pain in adolescents.
HDAC6 Suppresses Let‐7i‐5p to Elicit TSP1/CD47‐Mediated Anti‐Tumorigenesis and Phagocytosis of Hepatocellular Carcinoma (2019)

Histone deacetylase 6 (HDAC6) uniquely serves as a tumor suppressor in hepatocellular carcinogenesis, but the underlying mechanisms leading to tumor suppression are not fully understood. To identify comprehensive microRNAs (miRNAs) regulated by HDAC6 in hepatocellular carcinogenesis, differential miRNA expression analysis of HDAC6-transfected Hep3B cells was performed. Using integrative analyses of publicly available transcriptome data and miRNA target prediction, we selected five candidate miRNAs and, through in vitro functional validation, showed that let-7i-5p specifically suppressed thrombospondin-1 (TSP1) in hepatocellular carcinoma (HCC). Ectopic expression of antisense let-7i-5p (AS-let-7i-5p) inhibited in vitro tumorigenesis of HCC cells. In addition, treatments of partially purified TSP1 from culture cell media (ppTSP1) and recombinant TSP1 (rTSP1) exhibited similar effects with AS-let-7i-5p treatment on the same HCC cells, whereas TSP1 neutralizing antibody treatment significantly attenuated these effects. Notably, treatments of HDAC6 plasmid, AS-let-7i-5p, ppTSP1, and rTSP1 significantly suppressed in vitro angiogenesis and metastatic potential of HCC cells, but the co-treatment of TSP1 antibody specific to cluster of differentiation 47 (CD47) binding domain successfully blocked these effects in the same cells. Furthermore, we demonstrated that recovery of HDAC6 elicited let-7i-5p suppression to de-repress TSP1 expression; therefore, it occupied the CD47 receptor to block CD47-SIRPα-mediated anti-phagocytosis of macrophage in HCC. We also observed that HCC-derived exosomal let-7i-5p suppressed TSP1 of recipient hepatocyte cells. Treatments of HDAC6 plasmid, AS-let-7i-5p, and rTSP1 suppressed tumor incidence as well as tumor growth rates in a spontaneous mouse HCC model. Conclusion: Our findings suggest that the HDAC6-let-7i-5p-TSP1 regulatory pathway suppresses neoplastic and antiphagocytic behaviors of HCC by interacting with cell surface receptor CD47 in HCC and neighboring cells of tumor microenvironment, providing a therapeutic target for the treatment of liver malignancy and metastasis.
Human attention and intent analysis using robust visual cues in a bayesian framework (2006)

Human-computer interaction is beginning to permeate all aspects of our lives. As we develop more and more interactive computer systems, it is important to develop proper tools and frameworks for making this interaction more efficient. These types of interactive systems can also increase the safety of everyday tasks. We propose a human attention and intent analysis system based on a probabilistic framework using visual cues to help increase the efficiency and safety of everyday tasks. We will specifically look at the driving task. By combining cues about the vehicle interior and driver, the vehicle state, and the vehicle surround, we can make estimates of the driver's focus of attention and intent. Research contributions will be made in the areas of head pose and facial affect analysis, lane detection and tracking, fusing multiple cues to generate estimates of both attention and intent, and overall system integration. A Bayesian framework allows us to effectively combine multiple modalities of cues from visual information as well as other sensors to generate estimates which take into account the uncertainty of both the observations and the underlying process as well as prior knowledge about the parameters we are estimating. This can help us assess critical situations and feedback information faster and more efficiently than systems that do not take into account the driver's attention or intent. We will also show statistical results demonstrating the accuracy of such a system in real-world conditions using data collected from a 28 different drivers.
Thermal Stability and Thermodynamic Properties of Hybrid Proton-Conducting Polyaryl Etherketones (2006)

The thermal and structural stability of sulfonated cross-linked PEEK (polyether ether ketone) and its silicon-containing class II hybrid derivatives were characterized by combination of mass spectrometry, infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and differential scanning calorimetry. Thermodynamic properties of the hybrids were determined, including glass-transition temperature, degree of crystallinity, and thermal stability. The decomposition processes of the hybrid polymers could be consistently interpreted and their energetics quantitatively determined. The introduction of inorganic silanol moieties improves the thermal stability compared to sulfonated products.
Is Value-Based Value Wasted? Examining Value-Based Insurance Designs Through the Lens of Cost-Effectiveness (2010)

ealth plan sponsors have long sought approaches to care management that not only reduce health care costs but also improve the health of plan members. Nearly a decade ago, disease management programs were first promoted as a possible solution. ] At one time called benefit-based copayments (BBC), the original VBID model called for a shifting of the health plan subsidy away from lowvalue utilization and towards high-value utilization.
Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity (2018)

Malaria remains a global health burden partly due to <i>Plasmodium</i> parasite resistance to first-line therapeutics. The molecular chaperone heat shock protein 90 (Hsp90) has emerged as an essential protein for blood-stage <i>Plasmodium</i> parasites, but details about its function during malaria's elusive liver stage are unclear. We used target-based screens to identify compounds that bind to <i>Plasmodium falciparum</i> and human Hsp90, which revealed insights into chemotypes with species-selective binding. Using cell-based malaria assays, we demonstrate that all identified Hsp90-binding compounds are liver- and blood-stage <i>Plasmodium</i> inhibitors. Additionally, the Hsp90 inhibitor SNX-0723 in combination with the phosphatidylinositol 3-kinase inhibitor PIK-75 synergistically reduces the liver-stage parasite load. Time course inhibition studies with the Hsp90 inhibitors and expression analysis support a role for <i>Plasmodium</i> Hsp90 in late-liver-stage parasite development. Our results suggest that <i>Plasmodium</i> Hsp90 is essential to liver- and blood-stage parasite infections and highlight an attractive route for development of species-selective <i>Pf</i>Hsp90 inhibitors that may act synergistically in combination therapies to prevent and treat malaria.
Internet of Spacecraft for Multi-planetary Defense and Prosperity (2022)

&lt;p&gt;Recent years have seen unprecedentedly fast-growing prosperity in the commercial space industry. Several privately funded aerospace manufacturers, such as Space Exploration Technologies Corporation (SpaceX) and Blue Origin have innovated what we used to know about this capital-intense industry and gradually reshaped the future of human civilization. As private spaceflight and multi-planetary immigration gradually become realities from science fiction (sci-fi) and theory, both opportunities and challenges are presented. In this article, a review of the progress in space exploration and the underlying space technologies is firstly provided. For the next, a revisit and a prediction are paid and made to the K-Pg extinction event, the Chelyabinsk event, extra-terrestrialization, terraforming, planetary defense, including the emerging near-Earth object (NEO) observation and NEO impact avoidance technologies and strategies. Furthermore, a framework of the Solar Communication and Defense Networks (SCADN) with advanced algorithms and high efficacy is proposed to enable an internet of distributed deep-space sensing, communications, and defense to cope with disastrous incidents such as asteroid/comet impacts. Furthermore, the perspectives on the legislation, management, and supervision of founding the proposed SCADN are also discussed in depth.&lt;/p&gt;
High-resolution temporal reconstruction of ankle joint from dynamic MRI (2018)

Cerebral palsy is the leading cause of motor disabilities affecting children. The ankle is the most common equine musculoskeletal strain in children with cerebral palsy. Despite multiple medical and surgical therapies, postoperative recurrence rate is still very high (48%). A major reason for therapy failure is the lack of knowledge of the ankle joint biomechanics. Dynamic MRI can be used to acquire high resolution static data and low resolution temporal images. However, spatial and temporal data should be combined to provide the most comprehensive point of view to study joint motion. In this paper, we first present an intensity-based registration method to accurately estimate the rigid motion of the ankle bones. Second, we investigate the use of the log-euclidean framework to reconstruct a four-dimensional (3D+time) high-resolution dynamic MRI sequence from a low-resolution dynamic sequence and one high resolution static MR image. The proposed approach has been applied and evaluated on in vivo MRI data acquired for a pilot study on child motor disability. Results demonstrate the robustness of the proposed pipeline and very promising high resolution visualization of the ankle joint.
Serological evidence of swine influenza in Brazil (2012)

The aim of this work was to detect serum antibodies specific to influenza viruses in swine in Brazil. Serum samples of 355 pigs from 17 herds in Minas Gerais state were tested by hemagglutination inhibition (HI) for antibodies against H1N1 swine (SIV) and human influenza viruses, and H3N2 SIV. HI revealed that 158 animals (44·5%) and 11 herds (64·7%) were positive for H1N1 SIV, 36 animals (10·1%) and four herds (23·5%) were positive for H3N2 SIV, and 136 animals (38·3%) and 10 herds (58·8%) were positive for H1N1 human. This study indicates that swine influenza is disseminated throughout Minas Gerais state, Brazil.
Délinquant, délinquance et insécurité: cinquante ans de traitement en Belgique, 1944-1994 (1995)

Doctorat en droit
Novel Mutations of the CYP2A6 Gene in a Thai Population with Lowered Capacity of Coumarin 7-Hydroxylation (2002)

We explored genetic polymorphisms in a Thai population which exhibited a low capacity to metabolize coumarin. The following two silent single nucleotide polymorphisms (SNPs) were found: 1) SNP, 020228Kiyotani001; GENE NAME, CYP2A6; ACCESSION NUMBER, NT_011139; LENGTH, 25 base; 5'-AAACTACCTGCAG/TCTGAACACAGAG-3'. 2) SNP, 020228Kiyotani002; GENE NAME, CYP2A6; ACCESSION NUMBER, NT_011139; LENGTH, 25 base; 5'-AATCCCCAGCAC/TTTCCTGAATGAG-3'. These two mutations (G144A and C1245T), which were located in exon 1 and exon 8 of the CYP2A6 gene, were found in two subjects among nine poor metabolizers for coumarin.
Mathematical Evaluation of the Amino Acid and Polyphenol Content and Antioxidant Activities of Fruits from Different Apricot Cultivars (2011)

Functional foods are of interest because of their significant effects on human health, which can be connected with the presence of some biologically important compounds. In this study, we carried out complex analysis of 239 apricot cultivars (Prunus armeniaca L.) cultivated in Lednice (climatic area T4), South Moravia, Czech Republic. Almost all previously published studies have focused only on analysis of certain parameters. However, we focused on detection both primary and secondary metabolites in a selection of apricot cultivars with respect to their biological activity. The contents of thirteen biogenic alpha-L-amino acids (arginine, asparagine, isoleucine, lysine, serine, threonine, valine, leucine, phenylalanine, tryptophan, tyrosine, proline and alanine) were determined using ion exchange chromatography with UV-Vis spectrometry detection. Profile of polyphenols, measured as content of ten polyphenols with significant antioxidant properties (gallic acid, procatechinic acid, p-aminobenzoic acid, chlorogenic acid, caffeic acid, vanillin, p-coumaric acid, rutin, ferrulic acid and quercetrin), was determined by high performance liquid chromatography with spectrometric/electrochemical detection. Moreover, content of total phenolics was determined spectrophotometrically using the Folin-Ciocalteu method. Antioxidant activity was determined using five independent spectrophotometric methods: DPPH assay, DMPD method, ABTS method, FRAP and Free Radicals methods. Considering the complexity of the obtained data, they were processed and correlated using bioinformatics techniques (cluster analysis, principal component analysis). The studied apricot cultivars were clustered according to their common biochemical properties, which has not been done before. The observed similarities and differences were discussed.
Combinatorial Auction-Based Two-Stage Matching Mechanism for Mobile Data Offloading (2017)

In this paper, we study the problem of mobile data offloading for a network that contains multiple mobile network operators (MNOs), multiple WiFi or femtocell access points (APs) and multiple mobile users (MUs). MNOs offload their subscribed MUs' data traffic by leasing the unused Internet connection bandwidth of third party APs. We propose a combinatorial auction-based two-stage matching mechanism comprised of MU-AP matching and AP-MNO matching. The MU-AP matching is designed to match the MUs to APs in order to maximize the total offloading data traffic and achieve better MU satisfaction. Conversely, for AP-MNO matching, MNOs compete for APs' service using the Nash bargaining solution (NBS) and the Vickrey auction theories and, in turn, APs will receive monetary compensation. We demonstrated that the proposed mechanism converges to a distributed stable matching result. Numerical results demonstrate that the proposed algorithm well capture the tradeoff among the total data traffic, social welfare and the QoS of MUs compared to other schemes. Moreover, the proposed mechanism can considerably offload the total data traffic and improve the network social welfare with less computation
Digital Video Broadcasting (DVB) the future of television (1998)

Digital Video Broadcasting (DVB) has become the synonym for digital television and for data broadcasting world-wide. DVB services have recently been introduced in Europe, in Northand South America, in Asia, Africa and Australia. This article aims at describing what DVB is all about and at introducing some of the technical background of a technology that makes possible the broadcasting of „datacontainers“ in which all kinds of digital data up to a datarate of 38 Mbit/s can be transmitted at bit-error rates in the order of 10.
Azabenzocycloheptenones. Part XIII. Ring expansion of 1,2-dihydroquinoline derivatives (1971)

Dibromocarbene reacts with 4-ethoxy-1,2-dihydro-1-p-tolylsulphonylquinolines to give adducts which can be converted in fair yield into 4-bromo-5-ethoxy-1-p-tolylsulphonyl[1]benzazepines and in poor yield into 4-bromo-1,2-dihydro-1-p-tolylsulphonyl[1]benzazepin-5-ones. 4-Ethoxy-1,2-dihydro-2-methyl-1-p-tolylsulphonylquinolines do not react with dihalogenocarbenes but an N-methylsulphonyl analogue reacts with dibromocarbene and the adduct can be ring-expanded to 2-methyl[1]benzazepine derivatives.
재활용 횟수에 따른 폴리프로필렌 및 탄소섬유 강화 PP 복합재료의 물성 변화 관찰 (2013)

탄소섬유(CF) 강화 폴리프로필렌(PP) 복합재료의 수요는 증가되고 있다. 본 연구에서는 재활용 횟수에 따라 변화되는 복합재료의 물성 변화를 관찰하였다. CF 함량을 20% 함량으로 조성한 복합재료에 대해서 재활용 횟수에 따른 기계적 물성 평가를 진행하였다. 인장, 굴곡, Izod 동적 피로 실험에 따른 영향을 확인하였다. CF/PP 복합재료의 계면 물성을 평가하기 위해 젖음성 평가와 파단면을 FE-SEM으로 확인하였다. 재활용 횟수에 따라 섬유와 기지는 변화된다. CF/PP 복합재료는 재활용 할수록 섬유와 기지간의 계면에 열 데미지와 분쇄 과정에 의한 결합력 감소가 확인하였다.
Raw Sewage Harbors Diverse Viral Populations (2011)

At this time, virology is focused on the study of a relatively small number of viral species. Specific viruses are studied either because they are easily propagated in the laboratory or because they are associated with disease. The lack of knowledge of the size and characteristics of the viral universe and the diversity of viral genomes is a roadblock to understanding important issues, such as the origin of emerging pathogens and the extent of gene exchange among viruses. Untreated wastewater is an ideal system for assessing viral diversity because virion populations from large numbers of individuals are deposited and because raw sewage itself provides a rich environment for the growth of diverse host species and thus their viruses. These studies suggest that the viral universe is far more vast and diverse than previously suspected.
Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2 (2017)

Copper is an essential element for proper organismal development and is involved in a range of processes, including oxidative phosphorylation, neuropeptide biogenesis, and connective tissue maturation. The copper transporter (Ctr) family of integral membrane proteins is ubiquitously found in eukaryotes and mediates the high-affinity transport of Cu<sup>+</sup> across both the plasma membrane and endomembranes. Although mammalian Ctr1 functions as a Cu<sup>+</sup> transporter for Cu acquisition and is essential for embryonic development, a homologous protein, Ctr2, has been proposed to function as a low-affinity Cu transporter, a lysosomal Cu exporter, or a regulator of Ctr1 activity, but its functional and evolutionary relationship to Ctr1 is unclear. Here we report a biochemical, genetic, and phylogenetic comparison of metazoan Ctr1 and Ctr2, suggesting that Ctr2 arose over 550 million years ago as a result of a gene duplication event followed by loss of Cu<sup>+</sup> transport activity. Using a random mutagenesis and growth selection approach, we identified amino acid substitutions in human and mouse Ctr2 proteins that support copper-dependent growth in yeast and enhance copper accumulation in Ctr1<sup>-/-</sup> mouse embryonic fibroblasts. These mutations revert Ctr2 to a more ancestral Ctr1-like state while maintaining endogenous functions, such as stimulating Ctr1 cleavage. We suggest key structural aspects of metazoan Ctr1 and Ctr2 that discriminate between their biological roles, providing mechanistic insights into the evolutionary, biochemical, and functional relationships between these two related proteins.
Next place prediction using mobility Markov chains (2012)

In this paper, we address the issue of predicting the next location of an individual based on the observations of his mobility behavior over some period of time and the recent locations that he has visited. This work has several potential applications such as the evaluation of geo-privacy mechanisms, the development of location-based services anticipating the next movement of a user and the design of location-aware proactive resource migration. In a nutshell, we extend a mobility model called Mobility Markov Chain (MMC) in order to incorporate the n previous visited locations and we develop a novel algorithm for next location prediction based on this mobility model that we coined as n-MMC. The evaluation of the efficiency of our algorithm on three different datasets demonstrates an accuracy for the prediction of the next location in the range of 70% to 95% as soon as n = 2.