gebhart/patrepeval huggingface dataset:
Pseudo-synchronous solutions for dissipative non-autonomous systems (2021)

In the framework of KAM theory, the persistence of invariant tori in quasi-integrable systems is proved by assuming a non-resonance condition on the frequencies, such as the standard Diophantine condition or the milder Bryuno condition. In the presence of dissipation, most of the quasi-periodic solutions disappear and one expects, at most, only a few of them to survive together with the periodic attractors. However, to prove that a quasi-periodic solution really exists, usually one assumes that the frequencies still satisfy a Diophantine condition and, furthermore, that some external parameters of the system are suitably tuned with them. In this paper we consider a class of systems on the one-dimensional torus, subject to a periodic perturbation and in the presence of dissipation, and show that, however small the dissipation, if the perturbation is a trigonometric polynomial in the angles and the unperturbed frequencies satisfy a non-resonance condition of finite order, depending on the size of the dissipation, then a quasi-periodic solution exists with slightly perturbed frequencies provided the size of the perturbation is small enough. If on the one hand the maximal size of the perturbation is not uniform in the degree of the trigonometric polynomial, on the other hand all but finitely many frequencies are allowed and there is no restriction arising from the tuning of the external parameters. A physically relevant case, where the result applies, is the spin-orbit model, which describes the rotation of a satellite around its own axis, while revolving on a Keplerian orbit around a planet, in the case in which the dissipation is taken into account through the MacDonald torque.
Immunosuppressive therapy of aplastic anemia: results of a prospective, randomized trial of antithymocyte globulin (ATG), methylprednisolone, and oxymetholone to ATG, very high-dose methylprednisolone, and oxymetholone (1992)

Sixty-eight patients with moderate (n = 15) or severe (n = 53) aplastic anemia were entered into a prospective, randomized, two-arm treatment study comparing antihuman thymocyte globulin (ATG), lower-dose methylprednisolone (LDM) and oxymetholone to ATG, higher-dose methylprednisolone (HDM), and oxymetholone. There were no differences between the two groups when comparing age, sex, etiology of aplasia, disease duration, severity of aplasia, or pretherapy granulocyte counts. Side effects of LDM and HDM were similar. Of the 64 patients evaluable for response to therapy, 12 of 33 (36%) who received LDM had complete, partial, or minimal responses compared with 15 of 31 patients (48%) who received HDM (P = .33). Actuarial survival at 4 years is 43% for patients in the LDM group and 47% for patients in the HDM group (P = .99). Causes of death included hemorrhage, infection, evolution to acute leukemia, and complications of subsequent bone marrow transplantation. Long-term complications included paroxysmal nocturnal hemoglobinuria (n = 3), evolution to myelodysplasia or acute leukemia (n = 6), and recurrent aplasia (n = 6). We were unable to show a significant difference in toxicity, response rate, or survival for patients treated with ATG, oxymetholone, and LDM compared with patients who received ATG, oxymetholone, and HDM.
Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma Presenting as a Suprasellar Mass: Case Report (2003)

Composite PXA-GG, although extremely rare, may present as a pediatric suprasellar mass. The histopathological diagnosis is contingent on the demonstration of distinct coincident PXA and GG components. The prognosis after gross subtotal resection is likely favorable; however, long-term follow-up monitoring is indicated for these rare neoplasms.
Soluble Receptors for Advanced Glycation End Products (sRAGE) as a Predictor of Restenosis Following Percutaneous Coronary Intervention (2010)

Both low serum sRAGE levels and high AGE/sRAGE ratio have predictive value for post-PCI restenosis.
Early road warrior. 2. Competing electric and gasoline vehicles [History] (2004)

This paper relates the historical development of electric and gasoline vehicles and compares the relative advantages and disadvantages of each. The paper also describes how the rapid technological advances in gasoline-fueled automobiles, from the introduction of the first Ford Model T in 1908, resulted in the eventual decline in the popularity of electric vehicles in 1914.
Abrogation of factor-dependence in two IL-3-dependent cell lines can occur by two distinct mechanisms. (1989)

We have investigated the mechanisms of abrogation of factor-dependence of lymphoid (FL5.12) and myeloid (FDC-P1) interleukin-3 (IL-3)-dependent cell lines following infection of the cells with retroviruses that encode different oncogenes and immediate selection of IL-3-independent growth. As previously reported by others, Abelson-MuLV (Ab-MuLV) transforms both cell lines to factor-independence, and the transformed cells express the viral oncogene, do not produce IL-3, and are tumorigenic. In contrast, IL-3-independent lymphoid and myeloid cell lines recovered after infection with retroviruses that encode v-src or v-fms oncogenes lacked the v-src or v-fms provirus. Three of seven IL-3-independent transformants were rearranged at the IL-3 locus, produced IL-3-specific mRNA, secreted IL-3 into the culture medium, and grew better in the presence of IL-3. These IL-3-independent transformants produced tumors upon inoculation into nude mice, albeit with longer latent periods than Ab-MuLV transformants. The expression of hematopoietic cell markers was compared in parental and IL-3-independent transformants by immunofluorescence and analysis of mRNA levels. Significant elevation of LFA-1 and MHC class I molecules and loss of expression of IL-2-receptor molecules was detected in most IL-3-independent transformants. These differences in antigen expression indicate that additional phenotypic changes accompany transformation to factor-independence.
Ionic Covalent Organic Frameworks with Spiroborate Linkage (2015)

A novel type of ionic covalent organic framework (ICOF), which contains sp(3) hybridized boron anionic centers and tunable countercations, was constructed by formation of spiroborate linkages. These ICOFs exhibit high BET surface areas up to 1259 m(2) g(-1) and adsorb a significant amount of H2 (up to 3.11 wt %, 77 K, 1 bar) and CH4 (up to 4.62 wt %, 273 K, 1 bar). Importantly, the materials show good thermal stabilities and excellent resistance to hydrolysis, remaining nearly intact when immersed in water or basic solution for two days. The presence of permanently immobilized ion centers in ICOFs enables the transportation of lithium ions with room-temperature lithium-ion conductivity of 3.05×10(-5) S cm(-1) and an average Li(+) transference number value of 0.80±0.02. Our approach thus provides a convenient route to highly stable COFs with ionic linkages, which can potentially serve as absorbents for alternative energy sources such as H2, CH4, and also as solid lithium electrolytes/separators for the next-generation lithium batteries.
Reducing pipeline energy demands with local DVS and dynamic retiming (2004)

The quadratic relationship between voltage and energy has made dynamic voltage scaling (DVS) one of the most powerful techniques to reduce system power demands. Recently, techniques such as Razor DVS, voltage overscaling, and Intelligent Energy Management have emerged as approaches to further reduce voltage by eliminating costly voltage margins inserted into traditional designs to ensure always-correct operation. The degree to which a global voltage controller can shave voltage margins is limited by imbalances in pipeline stage latency. Since all pipeline stages share the same voltage, the stage exercising the longest critical path will define the overall voltage of the system, even if other stages could potentially run at lower voltages. In this paper, we evaluate two local tuning mechanisms in the context of Razor DVS, a local voltage controller scheme that allows each pipeline stages it's own voltage level, and a lower cost dynamic retiming scheme that incorporates per-stage clock delay elements to allow longer-latency pipeline stages to "borrow" time from shorter-latency stages.
A new toroidal-meander type integrated inductor with a multilevel meander magnetic core (1994)

A novel toroidal-meander type integrated (TMTI) inductor with a multilevel meander magnetic core has been designed, fabricated, and integrated onto a silicon wafer. In a conventional inductor, conductor wires are wound around magnetic cores. By switching the roles of conductor wire and magnetic core, i.e., by 'wrapping' a magnetic core around a conductor wire, the same effect can be realized in a planar geometry. This geometry has been implemented using multilevel metal interconnection schemes, by interlacing a meander planar conductor with a multilevel meander magnetic core. The total inductor size is 4 mm/spl times/1.0 mm, the coil has 30 turns, and the magnetic material used was electroplated nickel(81%)-iron(19%) Permalloy. An inductance of 30 nH/mm/sup 2/ was achieved at a frequency of 5 MHz. The fabrication sequence of this inductor structure is entirely compatible with post-processing of standard bipolar and CMOS circuitry, as well as the fabrication of multichip module substrates, thus enabling the integration of the inductor structure with control circuitry for applications such as filters, sensors, magnetic microactuators, and low-power voltage converters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Palladium‐Catalyzed Sequential Alkylation—Alkenylation Reactions: Application Towards the Synthesis of Polyfunctionalized Fused Aromatic Rings. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
High-Temperature Synthesis of Materials: Glycothermal Synthesis of Alpha Aluminum Oxide (1997)

A technology for the glycothermal synthesis of α-Al2O3 particles of controlled size and shape has been developed. This technique allows for the production of anisometrically shaped particles with controlled morphology and size distribution. Morphological control of particle shape is described as a function of reaction conditions in which platelet morphologies are produced at high shear rates and polyhedra are formed at low shear rates. Particle size control is also investigated via the use of seed materials which promote epitaxial growth, thereby reducing the surface energy contribution to the nucleation barrier, α-Al2O3 seed materials can be used to form particle sizes as small as 100-200 nm without agglomeration. α-Fe2O3 seeds have similar effects in comparison with the α-Al2O3 seeds, but require higher values of seed number concentration to achieve equivalent particle size effects. Morphological control is unaffected by seeding additions.
Influence of Hypercholesterolemia and Adventitial Inflammation on the Development of Aortic Aneurysm in Rabbits (1997)

Abdominal aortic aneurysms are characterized by intimal atherosclerosis, disruption and attenuation of the elastic media, and a variable adventitial inflammatory infiltrate. We have developed an animal model of this disorder to evaluate the contribution of hypercholesterolemia, medial injury, and adventitial inflammation to aneurysmal dilatation. To accomplish this, we used periaortic application of calcium chloride, which induced both medial injury with calcification and endothelial injury. Ultrasonography was used to demonstrate the dilatation and thickening of the aortic wall. Over the first 3 weeks after periaortic application of 0.25 mol/L CaCl2, the external aortic diameter increased from 3.5 +/- 0.5 to 4.2 +/- 0.8 mm, but the ID remained unchanged. This apparent wall thickening was accompanied by vascular remodeling, and biochemical changes included approximately 50% reduction in tissue hydroxyproline concentration and increased activity of gelatinases (matrix metalloproteinase [MMP]-2 and MMP-9). Independently, cholesterol feeding to induce hypercholesterolemia or the concomitant periaortic application of thioglycollate had little effect on the histological, biochemical, or diameter changes. Together, hypercholesterolemia and thioglycollate were associated with rapid aortic dilatation in CaCl2, treated animals but not controls: after 3 weeks, the ID and OD had doubled, the OD increasing from 3.5 +/- 0.4 to 7.1 +/- 0.4 mm, P = .005. The remarkable feature that accompanied this dilatation was the infiltration of cells, mostly foamy macrophages, into the adventitia, with a further reduction in hydroxyproline concentration. Adventitial inflammation may provide the critical stimulus to dilatation of an aorta with preexisting intimal and medial injury.
Cord blood leptin and gains in body weight and fat mass during infancy (2016)

These are the first data to show that associations between higher cord blood leptin and slower weight gain during infancy are driven by lower increases in adiposity, at least in early infancy.
Cis, anti, cis‐Tricyclo[5.3.0.02,6]deca‐4,9‐dione (1977)

Abstract The chemical behavior and some physical properties (dipole moment, IR. vs. Raman spectra) of the titled compound are not fully consistent with a strictly centrosymmetric structure which might be expected for the anti configuration. The carbonyl groups are less reactive toward nucleophilic reagents and sp 2 → sp 3 transformations as compared to cyclopentanone systems.
On-chip enucleation of oocyte using untetherd micro-robot with gripping mechanism (2013)

We developed a highly functional untethered micro-robot that can manipulate cells with high gripping force in a micro-fluidic chip. The robot has gripping mechanism which is actuated by magnetic power. A permanent magnet is attached at the center of the gripping mechanism, and an electrical magnet controls the position of the magnet from the bottom of the micro-fluidic chip. The open-close accuracy of the gripper is about 3.0 μm. We succeeded in cutting of zona pelucida of oocyte and enucleation by using this micro-robot.
Active pixel and photon counting imagers based on poly-Si TFTs: rewriting the rule book on large area flat panel x-ray devices (2009)

The near-ubiquity of large area, active matrix, flat-panel imagers (AMFPIs) in medical x-ray imaging applications is a testament to the usefulness and adaptability of the relatively simple concept of array pixels based on a single amorphous silicon (a-Si:H) TFT coupled to a pixel storage capacitor. Interestingly, the fundamental advantages of a-Si:H thin film electronics (including compatibility with very large area processing, high radiation damage resistance, and continued development driven by interest in mainstream consumer products) are shared by the rapidly advancing technology of polycrystalline silicon (poly-Si) TFTs. Moreover, the far higher mobilities of poly-Si TFTs, compared to those of a- Si:H, facilitate the creation of faster and more complex circuits than are possible with a-Si:H TFTs, leading to the possibility of new classes of large area, flat panel imagers. Given recent progress in the development of initial poly-Si imager prototypes, the creation of increasingly sophisticated active pixel arrays offering pixel-level amplification, variable gain, very high frame rates, and excellent signal-to-noise performance under all fluoroscopic and radiographic conditions (including very low exposures and high spatial frequencies), appears within reach. In addition, it is conceivable that the properties of poly-Si TFTs could allow the development of large area imagers providing single xray photon counting capabilities. In this article, the factors driving the possible realization of clinically practical active pixel and photon counting imagers based on poly-Si TFTs are described and simple calculational estimates related to photon counting imagers are presented. Finally, the prospect for future development of such imagers is discussed.
Malfunction data management system for facility life cycle maintenance (2003)

In order to perform effective maintenance throughout the facility life cycle, it is necessary to have an information management system. which can support it effectively. In this paper, we propose a system to collect the malfunction data and that for the prediction of component deterioration of the facility as a part of the facility information management system. The former system is to support the collection of malfunction data with reference to a facility model, which represents the hierarchical structure of the facility. The latter system is to predict the potential deterioration occurring on the facility components based on the knowledge collected by the malfunction data collection system.
Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway Hyperresponsiveness (2012)

We established a diphtheria toxin (DT)-based conditional deletion system using Il4 enhancer elements previously shown to be specific for IL-4 production in mast cells (MCs) or basophils (Mas-TRECK and Bas-TRECK mice). DT treatment of Bas-TRECK mice resulted in specific deletion of basophils, whereas both MCs and basophils were deleted in Mas-TRECK mice. DT-treated Mas-TRECK mice had impaired passive cutaneous anaphylaxis, IgE-mediated passive systemic anaphylaxis, and IgE-mediated chronic allergic inflammation, whereas DT-treated Bas-TRECK mice had impaired IgE-mediated chronic allergic inflammation. Using these mice, we also sought to tease out the role of MCs and basophils in airway hyperresponsiveness (AHR). Although MC deletion resulted in a slight increase in basal Ag-specific IgE levels and significant increases in basal IgE levels, we found that this deletion markedly impaired the AHR effector phase and was accompanied by decreased histamine levels. By contrast, basophil deletion had no effect on the AHR effector phase or on IgE production induced by systemic OVA immunization. Our results, using these newly established Mas-TRECK and Bas-TRECK models, demonstrated an indispensable role for MCs as effector cells in AHR.
Novel Therapeutic Targets for Sepsis: Regulation of Exaggerated Inflammatory Responses (2012)

Sepsis is a devastating and complex syndrome and continues to be a major cause of morbidity and mortality among critically ill patients at the surgical intensive care unit setting in the United States. The occurrence of sepsis and septic shock has increased significantly over the past two decades. Despite of highly dedicated basic research and numerous clinical trials, remarkable progress has not been made in the development of novel and effective therapeutics. The sepsis-induced physiologic derangements are due largely to the host responses to the invading microorganism in contrast to the direct effects of the microorganism itself. Sepsis, the systemic inflammatory response to infection, is marked by dysregulated production of pro-inflammatory cytokines. Although pro-inflammatory cytokine production is normally indispensable to protect against pathogens and promote tissue repair, the dysregulated and prolonged production of these cytokines can trigger a systemic inflammatory cascade mediated by chemokines, vasoactive amines, the complement and coagulation system, and reactive oxygen species (ROS), amongst others. These mediators collectively lead to multiple organ failure, and ultimately to death. In this regard, the role of inflammation in the pathophysiology of sepsis, although still incompletely understood, is clearly critical. Recent findings resulting from vigorous investigations have contributed to delineate various novel directions of sepsis therapeutics. Among these, this review article is focused on new promising mechanisms and concepts that could have a key role in anti-inflammatory strategies against sepsis, including 1) "inflammasome": a multiprotein complex that activates caspase-1; 2) "the cholinergic anti-inflammatory pathway": the efferent arm of the vagus nerve-mediated, brain-to-immune reflex; 3) "stem cells": unspecialized and undifferentiated precursor cells with the capacity for self-renewal and potential to change into cells of multiple lineages; 4) "milk fat globule-EGF factor VIII (MFG-E8)": a bridging molecule between apoptotic cells and phagocytes, which promotes phagocytosis of apoptotic cells.
Evidence that L-(+)-lactate dehydrogenase deficiency is lethal in Streptococcus mutans (1994)

In order to construct an effector strain for the replacement therapy of dental caries, we wished to combine the properties of low-level acid production and high-level colonization potential in a strain of Streptococcus mutans. To this end, we made a deletion in the lactate dehydrogenase (LDH) gene cloned from the bacteriocin-producing S. mutans strain JH1000. However, we were unable to substitute the mutant for the wild-type allele by transformation with linear DNA fragments. The mutated gene, carried on a suicide vector, was shown by Southern analysis to integrate into the JH1000 chromosome to yield transformants carrying both the wild-type gene and mutated LDH gene. Three spontaneous self-recombinants of one heterodiploid strain were isolated by screening 1,500 colonies for a loss of the tetracycline resistance encoded by the gene used to mark the LDH deletion. In all three cases, Southern analysis showed that a loss of tetracycline resistance was accompanied by a loss of the mutated LDH gene, resulting in restoration of the wild-type genotype. However, screening the same number of colonies for self-recombinants that did not make lactic acid during anaerobic growth in Todd-Hewitt broth failed to identify clones in which the wild-type allele was lost. A second, simpler screening of more than 80,000 colonies grown aerobically on glucose tetrazolium medium to identify low-level-acid-producing colonies was also unsuccessful. These results are interpreted as indicating that LDH deficiency is lethal in S. mutans under the cultivation conditions used in these experiments. The physiological bases for this hypothesis are described.
Muscular Gene Transfer Using Nonviral Vectors (2008)

Skeletal muscle is a target tissue of choice for the gene therapy of both muscle and non-muscle disorders. Investigations of gene transfer into muscle have progressed considerably from the expression of plasmid reporter genes to the production of therapeutic proteins such as trophic factors, hormones, antigens, ion channels or cytoskeletal proteins. Viral vectors are intrinsically the most efficient vehicles to deliver genes into skeletal muscles. But, because viruses are associated with a variety of problems (such as immune and inflammatory responses, toxicity, limited large scale production yields, limitations in the size of the carried therapeutic genes), nonviral vectors remain a viable alternative. In addition, as nonviral vectors allow to transfer genetic structures of various sizes (including large plasmid DNA carrying full-length coding sequences of the gene of interest), they can be used in various gene therapy approaches. However, given the lack of efficiency of nonviral vectors in experimental studies and in the clinical settings, the overall outcome clearly indicates that improved synthetic vectors and/or delivery techniques are required for successful clinical gene therapy. Today, most of the potential muscle-targeted clinical applications seem geared toward peripheral ischemia (mainly through local injections) and cancer and infectious vaccines, and one locoregional administration of naked DNA in Duchenne muscular dystrophy. This review updates the developments in clinical applications of the various plasmid-based non-viral methods under investigation for the delivery of genes to muscles.
Supplementary Table 1 from Immunodetection of DNA Repair Endonuclease ERCC1-XPF in Human Tissue (2023)

Supplementary Table 1 from Immunodetection of DNA Repair Endonuclease ERCC1-XPF in Human Tissue