gebhart/patrepeval huggingface dataset:
Supplementary Table 7 from Relationship of Mammographic Density and Gene Expression: Analysis of Normal Breast Tissue Surrounding Breast Cancer (2023)

&lt;p&gt;Supplementary Table 7 - PDF file 49K, Adjusted relationship of biologically relevant signatures with the Active/Inactive extratumoral microenvironment subtype, mammographic density, and breast composition&lt;/p&gt;
Preliminary evidence for biologic activity of toceranib phosphate (Palladia®) in solid tumours (2011)

The purpose of this study was to provide an initial assessment of the potential biologic activity of toceranib phosphate (Palladia®, Pfizer Animal Health, Madison, NJ, USA) in select solid tumours in dogs. Cases in which toceranib was used to treat dogs with apocrine gland anal sac adenocarcinoma (AGASACA), metastatic osteosarcoma (OSA), thyroid carcinoma, head and neck carcinoma and nasal carcinoma were included. Clinical benefit (CB) was observed in 63/85 (74%) dogs including 28/32 AGASACA [8 partial response (PR), 20 stable disease (SD)], 11/23 OSAs (1 PR and 10 SD), 12/15 thyroid carcinomas (4 PR and 8 SD), 7/8 head and neck carcinomas [1 complete response (CR), 5 PR and 1 SD] and 5/7 (1 CR and 4 SD) nasal carcinomas. For dogs experiencing CB, the median dose of toceranib was 2.8 mg kg(-1) , 36/63 (58.7%) were dosed on a Monday/Wednesday/Friday basis and 47/63 (74.6%) were treated 4 months or longer. Although these data provide preliminary evidence that toceranib exhibits CB in dogs with certain solid tumours, future prospective studies are necessary to define its true activity.
TDS-OFDMA: a novel multiple access system based on TDS-OFDM (2011)

As the key technology of Chinese national digital television terrestrial broadcasting (DTTB) standard, time domain synchronous OFDM (TDS-OFDM) utilizes known training sequence instead of cyclic prefix (CP) as the guard interval between adjacent inverse discrete Fourier transform (IDFT) blocks to achieve better system performance. Until now, TDS-OFDM was primarily used in downlink broadcasting. When TDS-OFDM is directly used in the uplink, it is difficult to eliminate the superposed interferences caused by different training sequences and IDFT blocks from multiple users. To solve this problem, a novel scheme called time domain synchronous orthogonal frequency division multiple access (TDS-OFDMA) is proposed in this paper. The novel space-time frame structure of the TDS-OFDMA scheme is proposed to achieve joint cyclicity reconstruction as well as joint channel estimation at the receiver. Simulation results show that the proposed scheme can achieve better bit error rate (BER) performance than conventional OFDMA system under highspeed mobile environments.
Mass transport properties of auxetic (negative Poisson's ratio) foams (2007)

Abstract An auxetic foam structure is described which has the property of widening when stretched (negative Poisson's ratio behaviour), in contrast to the situation with most materials which narrow when stretched. The fabrication of this material involves a combination of heat and compressive treatments of a conventional commercial air‐filtration foam. The resulting microstructure is examined by scanning electron microscopy (SEM). The pertinent mechanical properties are described in terms of the changes in specimen dimensions and associated strains. From these quantities, Poisson's ratios are determined for the large strain regime involved. The property of being able to open pores by stretching the material is a useful feature in various types of filtration application. In particular, where the long‐term efficiency of the process is hindered by ingress of particles into the system which block the active pore structure, the marriage of permeability and mechanical deformation via a negative Poisson's ratio offers an alternative to other methods of clearance. This notion is illustrated by the use of some very simple tests in which the foam is challenged by glass beads of uniform diameter. Simple air pressure‐drop tests are also performed on auxetic and conventional foams to demonstrate that the change in permeability due to mechanical deformation enables a means of varying the pressure‐drop acting across an auxetic foam to a far greater degree than is possible for the conventional foams. (© 2007 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
A virtual trial framework for quantifying the detectability of masses in breast tomosynthesis projection data (2013)

The authors have demonstrated a novel simulation framework and tools for evaluating DBT systems in an objective, task-specific manner. This framework facilitates further investigation of image quality tradeoffs in DBT.
SUPRAMOLECULAR ASSEMBLIES DNA used to organize gold nanoparticles (1996)

RETURN TO ISSUEPREVNewsNEXTSUPRAMOLECULAR ASSEMBLIES DNA used to organize gold nanoparticlesRON DAGANICite this: Chem. Eng. News 1996, 74, 34, 6–7Publication Date (Print):August 19, 1996Publication History Published online12 November 2010Published inissue 19 August 1996https://pubs.acs.org/doi/10.1021/cen-v074n034.p006https://doi.org/10.1021/cen-v074n034.p006newsACS PublicationsCopyright © 1996 American Chemical SocietyArticle Views11Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Colloidal particles,Genetics,Metal nanoparticles,Nanoparticles Get e-Alerts
ATP-citrate-lyase as a target for hypolipidemic intervention. Sulfoximine and 3-hydroxy-.beta.-lactam containing analogs of citric acid as potential tight-binding inhibitors (1992)

Citric acid analogues (+/-)-12a,b and (+/-)-17a,b, where one of the primary carboxylates has been replaced by a sulfoximinoyl and a 3-(3-hydroxy-beta-lactamyl) moiety, respectively, have been synthesized and evaluated as inhibitors of ATP-citrate lyase. The design of these inhibitors was based on methionine sulfoximine and tabtoxinine beta-lactam, potent, tight-binding inhibitors of glutamine synthetase. Both ATP-citrate lyase and glutamine synthetase employ phosphate-carboxylate anhydrides as a method for carboxylate activation during catalysis. Only one diastereomer, (+/-)-12a, displayed weak, reversible inhibition, while the remaining citrate analogues (+/-)-12b and (+/-)-17a,b were inactive against the lyase. No time-dependent inactivation of the enzyme was observed.
Boundary input-to-state stabilization of a damped Euler-Bernoulli beam in the presence of a state-delay (2019)

This paper is concerned with the point torque boundary feedback stabilization of a damped Euler-Bernoulli beam model in the presence of a time-varying state-delay. First, a finite-dimensional truncated model is derived by spectral reduction. Then, for a given stabilizing state-feedback of the delay-free truncated model, an LMI-based sufficient condition on the maximum amplitude of the state-delay is employed to guarantee the stability of the closed-loop state-delayed truncated model. Second, we assess the exponential stability of the resulting closed-loop infinite-dimensional system under the assumption that the number of modes of the original infinite-dimensional system captured by the truncated model has been selected large enough. Finally, we consider in our control design the possible presence of a distributed perturbation, as well as additive boundary perturbations in the control inputs. In this case, we derive for the closed-loop system an exponential input-to-state estimate with fading memory of the distributed and boundary disturbances.
Evaluación técnico-económica de la producción de bioetanol a partir de residuos lignocelulósicos (2008)

El bioetanol es uno de los principales biocombustibles, en estado puro o bien en mezclas con gasolina, para uso en vehículos automotores en países como Brasil y los Estados Unidos de América (EEUU) donde la producción en 2007 alcanza 19,000 y 24,600 MML/año a partir de caña de azúcar y maíz, respectivamente. Sin embargo, la utilización de dichas materias primas compromete y encarece la producción de alimentos para consumo humano y animal y presentan un balance energético (energíabioetanol/energíafósil) poco atractivo. Una alternativa tecnológica que permite superar esos problemas es la utilización de residuos lignocelulósicos como el bagazo de caña de azúcar obtenido en la refinación del azúcar como alternativa en la producción de bioetanol carburante en México. Se construyó una simulación del proceso completo de producción de bioetanol mediante la utilización del software comercial Superpro Designer y que considera únicamente las operaciones unitarias corriente arriba (upstream) de la fermentación de los azúcares para fines de una evaluación técnico-económica. Tal consideración se basa en que el análisis del estado del arte de la tecnología indica que los principales cuellos de botella técnicos y económicos se sitúan en el pretratamiento de la materia lignocelulósica, la sacarificación y la fermentación de las hexosas y pentosas presentes en el bagazo de caña de azúcar. Mediante el tratamiento de los resultados del simulador a diferentes niveles de conversión y utilizando un diseño de superficie de respuesta, el presente trabajo permitió identificar las limitaciones técnicas de la tecnología así como de los parámetros económicos del procesamiento de bagazo de caña de azúcar. Finalmente, los resultados obtenidos se interpretaron tomando como base el escenario de substitución total de los agentes oxigenantes usados en las gasolinas en México.
On the Design of a High Data Rate Underwater Acoustic Receiver (2022)

In this paper, we propose a novel design for a high-speed underwater acoustic (UWA) receiver chain. Towards this objective, we introduce a novel closed-loop, adaptive, single-rate Doppler scale estimation and compensation algorithm and a novel dual-domain channel estimation and equalization technique. We validate our results and evaluate the proposed schemes using extensive simulations based on channel models generated from the analysis of the Kauai Acomms MURI 2011 (KAM11) UWA communications experiment's recording. The extensive simulations show that the proposed algorithms exhibit superior performance compared to the state-of-the-art.
A novel adaptive structure of the energy detector applied to cognitive radio networks (2009)

The energy detector (ED) is one of the spectrum sensing techniques that is used in the cognitive radio networks to detect the presence of the primary user (PU) in a certain spectrum band. This technique assumes that the PU is either present or absent during the sensing time. However, the ED's performance degrades in a scenario when the PU is absent and then appears during the sensing time. The ED's performance is evaluated for this scenario and a novel adaptive ED structure is proposed to improve the detector performance. Analytical performance evaluation of the adaptive ED along with simulation results show that the proposed ED structure improves the probability of detection compared to the conventional ED.
Data-Driven Calibration Estimation for Robust Remote Pulse-Oximetry (2019)

Pulse-oximetry has become a core monitoring modality in most fields of medicine. Typical dual-wavelength pulse-oximeters estimate blood oxygen saturation (SpO2) levels from a relationship between the amplitudes of red and infrared photoplethysmographic (PPG) waveforms. When captured with a camera, the PPG waveforms are much weaker and consequently the measurement is more sensitive to distortions and noises. Therefore, an indirect method has recently been proposed where, instead of extracting the relative amplitudes from the individual waveforms, the waveforms are linearly combined to construct a collection of pulse signals with different pulse signatures, each corresponding to a specific oxygen saturation level. This method has been shown to outperform the conventional ratio-of-ratios based methods, especially when adding a third wavelength. Adding wavelengths, however, complicates the calibration. Inaccuracies in the calibration model threaten the performance of the method. Opto-physiological models have been shown earlier to provide useful calibration parameter estimates. In this paper, we show that the accuracy can be improved using a data-driven approach. We performed 5-fold cross validation on recordings with variations in oxygen saturation and optimized for pulse quality. All evaluated wavelength combinations, also without visible red, meet the required ISO standard accuracy with the calibration from the proposed method. This scalable approach is not only helpful to fine-tune the calibration model, but even allows computation of the calibration model parameters from scratch without prior knowledge of the data acquisition details, i.e., the properties of camera and illumination.
Nonunion After Functional Brace Treatment of Diaphyseal Humerus Fractures (2007)

Compared with the epidemiology of acute diaphyseal humerus fractures, nonunions after functional bracing are more likely to follow spiral/oblique fractures that involve the mid- or proximal-third of the diaphysis. Operative treatment can gain union and improve arm function.
An Integrated Workflow for Analysis of ChIP-Chip Data (2008)

Although ChIP-chip is a powerful tool for genome-wide discovery of transcription factor target genes, the steps involving raw data analysis, identification of promoters, and correlation with binding sites are still laborious processes. Therefore, we report an integrated workflow for the analysis of promoter tiling arrays with the Genomatix ChipInspector system. We compare this tool with open-source software packages to identify PU.1 regulated genes in mouse macrophages. Our results suggest that ChipInspector data analysis, comparative genomics for binding site prediction, and pathway/network modeling significantly facilitate and enhance whole-genome promoter profiling to reveal in vivo sites of transcription factor-DNA interactions.
Abstract 5452: Discovery of a novel seleno-leonurine analog as a potential therapeutic for ovarian cancer (2022)

Abstract Leonurine is an active alkaloid that is extracted from Traditional Chinese Medicine Herba leonuri. It has been reported to be beneficial for cardiovascular diseases, including atherosclerosis, acute and chronic myocardial infarction (MI), and ischemic stroke. Mao et al. illustrated that leonurine could up-regulate the expression of phosphorylated p38 and down-regulate phosphorylated Akt expression through inhibiting mitochondrial pathway, thus suppressing the proliferation and promoting lung cancer cell apoptosis. Accumulating evidence suggest that the extract of Leonurus sibiricus transgenic roots could induce apoptosis in different grades of human glioma cells and significantly promotes cisplatin sensitivity in cervical cancer cells via repressing cell proliferation, improving intrinsic cell apoptosis and inhibiting the expression of P-Gp and MRP1 protein, which has potential therapeutic value in cervical cancer treatment. In the present study, we designed and synthesized several selenium analogs of leonurine and their cytotoxicity were assessed using four different ovarian cancer cell lines viz. OVCAR-3, OVCAR-10, ES2, and drug resistant HeyA8 cells. Compared to the control and leonurine group, compound 834 inhibited the ovarian cancer cell viability in dose- and time-dependent manner. The IC50 values of compound 834 was 4.6 µM, 3.8 µM, 6.2 µM, and 5.7 µM for OVCAR-3, HeyA8, OVCAR-10, and ES2 cells, respectively, while for leonurine the IC50 value was &amp;gt;500 µM for 48 h treatment. To further acquaint the effect of 48 h treatment on cell proliferation, we performed trypan blue cell viability assay, trypan blue dye exclusion assay, Annexin V/7-AAD, Caspase 3/7 apoptosis assays and Western blotting of apoptotic proteins involved in apoptosis. Compound 834 significantly induced apoptosis in OVCAR-3 and HeyA8 cells in dose dependent manner. Upregulation of several apoptotic proteins, as evident by Western blot, suggested that 834 causes induction of apoptotic pathways efficiently. Further, the cell cycle analysis showed a significant arrest of OVCAR-3 and HeyA8 cells in the S-phase, which was further confirmed by the analysis of cyclin A2, cyclin-E1, p21 and p27 proteins expression. Conclusively, our research revealed that leonurine analog 834 significantly induces apoptosis in ovarian cancer cells via repressing cell proliferation, improving intrinsic cell apoptosis and inhibiting the expression of several signaling proteins, which has potential therapeutic value in ovarian cancer treatment. Citation Format: Asif Raza, Jacek Krzeminski, Shantu Amin, Arun Sharma. Discovery of a novel seleno-leonurine analog as a potential therapeutic for ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5452.
Evolution of methotrexate resistance of human acute lymphoblastic leukemia cells in vitro. (1985)

A human acute lymphoblastic T-cell line, MOLT-3, was fed with Roswell Park Memorial Institute Medium 1640 supplemented with 10% fetal bovine serum and antibiotics which contained increasing concentrations of methotrexate (MTX). The development of drug resistance was associated initially with progressive decrease in MTX transport. When the cells became 200-fold resistant, a rise in the dihydrofolate reductase was noted which was short-lived in the absence of the drug. A 10,000-fold increase in MTX resistance was accompanied, in addition to further decrease in MTX transport, by a 10-fold increase in the dihydrofolate reductase activity. While the purely transport-related resistant cell lines had a collateral sensitivity to lipid-soluble antifols, the sublines which had both transport- and enzyme-related MTX resistance contained a subpopulation highly resistant to these antifols. Chromosome analysis of the subline with increased dihydrofolate reductase activity showed an expanded abnormally banded region in chromosome 5.
A Power Control-Based MF-TDMA Resource Allocation Scheme for Next Generation Military Satellite Communication Systems (2012)

본 논문에서는 차기 군 위성통신망 체계에서 서로 다른 통신 능력을 갖는 이기종 단말을 동일 중계기 대역폭내에서 효과적으로 통합하여 운용하기 위해 전력제어를 적용한 MF-TDMA 자원할당기법을 제안한다. 제안하는 알고리즘은 burst 크기 결정 단계와 burst 구조 결정단계의 2단계로 수행된다. 먼저 burst 크기 결정 단계에서는 각 단말의 채널 상태를 기반으로 링크 버짓을 분석하여 적용 가능한 ACM 레벨과 이에 따른 burst 크기를 결정한다. 다음으로 burst 구조 결정단계에서는 앞서 도출된 각 단말 별 burst 크기를 기반으로 시간-주파수 축 상에서 할당 가능한 burst 구조를 도출하고 각 구조 별 가용 Power spectral density(PSD) 구간을 계산한다. 이기종 단말을 단일 중계기로 통합하기 위해 각 burst의 가용 PSD 구간 내에서 전력제어를 수행하며, 동일 PSD 구간을 갖는 burst를 그룹화하여 MF-TDMA 프레임 내에 할당한다. 추가적으로 할당되지 못하고 남는 슬롯에 대한 자원할당 효율을 향상시키기 위해 설정된 PSD 구간 내에서 ACM 레벨을 조절하여 빈 슬롯을 활용할 수 있는 방안을 적용하였다. 제안하는 알고리즘은 주파수 사용효율, 슬롯할당 거부율 및 burst packing 효율 측면에서 기존 방식과 비교하였으며, 기존 방식에 비해 우수한 성능을 제공함을 확인하였다. In this paper, an efficient power control based MF-TDMA resource allocation scheme is proposed for next generation military satellite communication systems. The proposed scheme has the flexibility is used to support heterogeneous terminals with differ in transmission capabilities. The method can be divided into two parts : burst size calculation and burst structure determination. At first, we estimate the link budget taken into account a dynamic satellite link state variation. Then, applicable ACM level and burst size is chosen. In burst structure determination phase, we reorganize the burst structure in time-frequency domain by controlling limited power, bandwidth, time resources. In particular, we compensate the power spectral density among different terminals to integrate them in same transponder, Furthermore, we increase the packing efficiency by controlling the ACM level of the burst in applicable power spectral density range. Simulation results show that the method increase the spectral efficiency and burst packing efficiency. In addition, slot allocation rejection ratio is successfully reduced.
Intravenous genetic mesothelin vaccine based on human adenovirus 40 inhibits growth and metastasis of pancreatic cancer (2012)

High pancreatic cancer mortality and poor prognosis are caused by the difficulty for early diagnosis and extremely low rates of resection because of metastasis. Mesothelin overexpression in pancreatic cancer is a remarkable biomarker for tumor progression, especially for invasion and metastasis. Here, we generated a novel replication-defective recombinant adenovirus 40 (rAd40), whose gene delivery properties are totally different from a conventional rAd5. In this study, we have identified intravenous administration with rAd40 expressing mouse mesothelin (Msln) as an effective prophylactic cancer vaccine against metastatic lesions of pancreatic cancer in mice. Intravenous administration of rAd40 (rAd40 i.v.) achieved transgene delivery in wider range of organs compared to rAd5 i.v., while rAd5 was distributed mainly to the liver, spleen, and lungs. Additionally, rAd40 i.v. showed less transduction of the liver or inflammatory responses, resulted in reduced liver toxicity compared to rAd5 i.v. Also, more robust systemic antigen-specific immune responses were stimulated by rAd40 i.v. Pretreatment with a single ovalbumin-expressing rAd40 i.v. prevented tumor growth in mouse subcutaneous models of ovalbumin-expressing pancreatic cancer. When used with Msln-expressing rAd40 i.v., Msln protein expression and metastases were suppressed in a syngeneic orthotopic mouse model of pancreatic cancer, corresponding to the detection of Msln- and tumor-specific cytotoxic T lymphocyte (CTL). Our novel methods generated antitumor effects against antigen-expressing tumors through antigen- and tumor-specific CTL-mediated immunity. Thus, our results indicate that a rAd40-based intravenous vaccine provides a new strategy for the effective control of metastatic pancreatic cancer and novel therapy against other cancers and infectious diseases.
A 1-V 8.1-$\mu$ W PPG-Recording Front-End With > 92-dB DR Using Light-to-Digital Conversion With Signal-Aware DC Subtraction and Ambient Light Removal (2019)

This letter reports on a photoplethysmogram (PPG) readout IC (ROIC), comprising an ultralow-power recording front-end and a 2-channel light-emitting diode (LED) driver. The front-end uniquely employs a continuous-time, first-order, incremental delta-sigma modulator (I-AΣM) for direct light-to-digital conversion in a single stage with duty-cycled operation for power savings. Moreover, the I-AΣM enables reconfigurable operation in intermittent conversion phases that allows the direct measurement of dc and ambient light-induced components of the photodiode current for signal-aware on-the-fly cancellation to recover the small ac PPG signal. Fabricated in 0.18-μm 1P/6M CMOS, the PPG ROIC features a high dynamic range of 92.7 dB, dissipates 8.1 μW and 1.95 mW in the recording front-end and the LED (with its driver), respectively, with ~10% duty cycling, and is validated by high-fidelity PPG recording from a human subject fingertip using an infrared LED.