gebhart/patrepeval huggingface dataset:
LMP-1's Transmembrane Domains Encode Multiple Functions Required for LMP-1's Efficient Signaling (2002)

The latent membrane protein-1 (LMP-1) of Epstein-Barr virus (EBV) contributes to the proliferation of infected B lymphocytes by signaling through its binding to cellular signaling molecules. It apparently mimics members of the tumor necrosis factor receptor family, in particular, CD40, by binding a similar set of cellular molecules as does CD40. LMP-1 differs dramatically in its structure from CD40. LMP-1 has six membrane-spanning domains as opposed to CD40's one. LMP-1 also differs from CD40 in its apparent independence of a ligand for its signaling. We have examined the role of LMP-1's membrane-spanning domains in its signaling. Their substitution with six membrane-spanning domains from the LMP-2A protein of EBV yields a derivative which neither coimmunoprecipitates with LMP-1 nor signals to increase the activity of NF-kappaB as does wild-type LMP-1. These observations indicate that LMP-1 has specific sequences in its membrane-spanning domains required for these activities. LMP-1's first and sixth membrane-spanning domains have multiple leucine residues potentially similar to leucine-heptad motifs that can mediate protein-protein interactions in membranes (Gurezka et al., J. Biol. Chem. 274:9265-9270, 1999). Substitution of seven leucines in LMP-1's sixth membrane-spanning domain has no effect on its function, whereas similar substitutions in its first membrane-spanning domain yielded a derivative which aggregates as does wild-type LMP-1 but has only 3% of wild-type's ability to signal through NF-kappaB. Importantly, this derivative complements a mutant of LMP-1 with wild-type membrane-spanning domains but no carboxy-terminal signaling domain. These findings together indicate that the membrane-spanning domains of LMP-1 contribute multiple functions to its signaling.
Narrowly Dispersed Double-Walled Concentric Hollow Polymeric Microspheres with Independent pH and Temperature Sensitivity (2008)

10.1021/ma801988a
Propagating imprecise engineering design constraints (2002)

Constraint based CAD systems are used to manipulate input and output variables by allowing a user to adjust the variables' crisp values. The different variables are iteratively specified and relaxed until a final configuration of variable values is accepted. This paper introduces a method for propagating imprecise (fuzzy) constraints to reduce the number of exploratory iterations required to obtain an acceptable set of values. An imprecision transformation is defined to induce imprecise specifications from specified variables to unspecified variables, either of which can be of the independent input or dependent output type. When the imprecise specifications are placed on the dependent variables exclusively, the transformation reduces to composition. When the imprecise specifications are placed on the input variables exclusively, the transformation becomes Zadeh's extension principle. In a traditional nonfuzzy use of constraint based CAD systems, an over-constrained system of relations must be relaxed by the user. With a fuzzy formulation, however, it is shown that imprecise constraints allow calculations to be made: the values which simultaneously satisfy all of the imprecise constraints can be calculated. Thus, using imprecise quantities in constraint based CAD systems allows much of the iterative user specifications to be calculated by the computing platform instead, reducing the iterative tasks of the designer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Phosphonate Aldehyde Annulation — A One‐Pot Synthesis of Hydroxycycloalkenoic Esters — Application to Analogues of Glycinoeclepin A. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Design and Synthesis of Novel Quinolinone-3-aminoamides and Their α-Lipoic Acid Adducts as Antioxidant and Anti-inflammatory Agents (2007)

A series of N-substituted-quinolinone-3-aminoamides and their hybrids containing the alpha-lipoic acid functionality were designed and synthesized as potential bifunctional agents combining antioxidant and anti-inflammatory activity. The new compounds were evaluated for their antioxidant activity and for their ability to inhibit in vitro lipoxygenase as well as for their anti-inflammatory activity in vivo. In general, the derivatives were found to be potent antioxidant or anti-inflammatory agents. The results are discussed in terms of structure-activity relationships and an attempt is made to define the structural features required for activity.
Effect of Several Temperature Regimes on the Development and Timing of Responsiveness of Males ofTrichoplusia nito the Female Sex Pheromone (1977)

Males of Trichoplusia ni (Hübner), the cabbage looper moth, were maintained at two constant temperature regimes, 25° and 15°C, as well as at an alternating 25° day:15° night regime. The males held at constant 15° required at least 9 days following emergence from the pupa to acquire maximal responsiveness to the synthetic female sex pheromone, cis -7-dodecenyl acetate, whereas those held at constant 25° or at 25:15° were maximally responsive by 3–5 days following emergence. Within a 10-hr scotophase, males held at 25°, 25:15°, and 15° achieved maximal pheromone responsiveness by the 7th, 3rd, and 1st hours, respectively, after the onset of darkness. This advancing of the diel expression of responsiveness with reducing temperatures is similar to that seen earlier for the time of release of pheromone by T. ni females. Males conditioned at the more natural, fluctuating (25:15°) temperatures tended to be 3 to 6-times more responsive to pheromone than those maintained at the constant (25° or 15°) temperatures.
One-step synthesis of S,B co-doped carbon dots and their application for selective and sensitive fluorescence detection of diethylstilbestrol (2018)

S,B co-doped carbon dots were synthesized, and their application in the detection of diethylstilbestrol.
Implementation of advanced process control-perspectives from academia (1998)

A successful collaboration between academia and industry in the implementation of advanced process control is one that develops new theory or methodology and also addresses a relevant industrial problem. Collaboration can provide significant benefits to an academic research group. However, there are a series of issues that must be addressed for the interaction to be successful. These benefits and issues are discussed in this paper.
From deterministic to fuzzy decision-making in artificial cells (2020)

Building autonomous artificial cells capable of homeostasis requires regulatory networks to gather information and make decisions that take time and cost energy. Decisions based on few molecules may be inaccurate but are cheap and fast. Realizing decision-making with a few molecules in artificial cells has remained a challenge. Here, we show decision-making by a bistable gene network in artificial cells with constant protein turnover. Reducing the number of gene copies from 10<sup>5</sup> to about 10 per cell revealed a transition from deterministic and slow decision-making to a fuzzy and rapid regime dominated by small-number fluctuations. Gene regulation was observed at lower DNA and protein concentrations than necessary in equilibrium, suggesting rate enhancement by co-expressional localization. The high-copy regime was characterized by a sharp transition and hysteresis, whereas the low-copy limit showed strong fluctuations, state switching, and cellular individuality across the decision-making point. Our results demonstrate information processing with low-power consumption inside artificial cells.
Acidocalcisomes ofPhytomonas françaiPossess Distinct Morphological Characteristics and Contain Iron (2004)

Acidocalcisomes are acidic calcium storage compartments described initially in trypanosomatid and apicomplexan parasites, and recently found in other unicellular eukaryotes. The aim of this study was to identify the presence of acidocalcisomes in the plant trypanosomatid Phytomonas françai. Electron-dense organelles of P. françai were shown to contain large amounts of oxygen, sodium, magnesium, phosphorus, potassium, calcium, iron, and zinc as determined by X-ray microanalysis, either in situ or when purified using iodixanol gradient centrifugation or by elemental mapping. The presence of iron is not common in other acidocalcisomes. In situ, but not when purified, these organelles showed an elongated shape differing from previously described acidocalcisomes. However, these organelles also possessed a vacuolar H+-pyrophosphatase (V-H+-PPase) as determined by biochemical methods and by immunofluorescence microscopy using antibodies against the enzyme. Together, these results suggest that the electron-dense organelles of P. françai are homologous to the acidocalcisomes described in other trypanosomatids, although with distinct morphology and elemental content.
Engineered neuron-targeting, placental mesenchymal stromal cell-derived extracellular vesicles for in utero treatment of myelomeningocele (2021)

ABSTRACT This study investigated the feasibility and efficiency of neuron-targeting hybrid placental mesenchymal stromal cell-derived extracellular vesicles (PMSC-EVs), engineered by membrane fusion with Targeted Axonal Import (TAxI) peptide modified, TrkB agonist 7,8-DHF-loaded liposomes for treatment of myelomeningocele (MMC) via intra-amniotic cavity administration. The prepared TAxI modified liposomes with 7,8-DHF were used to fuse with PMSC-EVs. Different fusion approaches were investigated and freeze-thaw-extrude method was found to be the optimal. The engineered PMSC-EVs had a uniform particle size and efficiently loaded 7,8-DHF. It also had typical markers of native EVs. Freeze-thaw-extrude process did not change the release profile of 7,8-DHF from engineered EVs compared to TAxI modified, 7,8-DHF loaded liposomes. The engineered EVs could elicit TrkB phosphorylation depending on the incorporation of 7,8-DHF while native EVs did not. The engineered EVs increased neurite outgrowth of apoptotic cortical neurons induced by staurosporine, suggesting that they exhibited neuroprotective function. In a rodent model of MMC, neuron-targeting, engineered EVs became an active targeting delivery system to MMC defect sites. Pups treated with engineered EVs had the lowest density of apoptotic cells and displayed a therapeutic outcome. The study suggests the potential use of engineered hybrid, active neuron-targeting EVs for the in utero treatment of MMC.
Effect of Venous Valves on Grafts for Coronary Artery Bypass (1992)

The effect of venous valves on blood flow and patency in grafts of the long saphenous vein for coronary artery bypass is examined. Our experimental model involved both diastolic-predominant blood flow and transient systolic regurgitation, and the waveform was similar to that of in vivo coronary circulation. In this model, blood flow was assessed in the presence or absence of venous valves. It was found that coronary artery blood flow was significantly greater in the presence of venous valves. Angioendoscopy showed that the movement of the graft valves was strong and rhythmic. It seems that valve preservation may be desirable in grafts for coronary artery bypass.
Coronary Artery Bypass Graft Disease (1995)

To prevent vein graft disease, surgeons should bypass diseased coronary arteries with at least one arterial graft and take measures during the surgery to avoid endothelial injury to vein grafts. Treatment with antiplatelet agents decreases the vein graft occlusion rate. When graft atherosclerosis causes symptoms, reoperation will probably prolong life if an old graft to the left anterior descending coronary artery is diseased. Reoperation increases a patient's chance for survival if the surgeon uses at least one arterial graft.
A New Power Management IC Architecture for Envelope Tracking Power Amplifier (2011)

A new supply modulator architecture for robust performance against the battery voltage variation is presented. The resulting modulator is an optimized power management integrated circuit (PMIC) for an envelope tracking (ET) power amplifier (PA). The basic topology of the PMIC is based on a hybrid switching amplifier combining a wideband class-AB buffered linear amplifier and a highly efficient switching-mode buck converter in a master-slave configuration. The additional boost converter regulates the supply voltage of the linear amplifier, while the supply of the buck converter is directly coupled to the battery. The proposed supply modulator achieves max/min efficiencies of 76.8/69.3% over the entire battery voltage range. The ET PA is operated at 4.5 V, providing higher output power, efficiency, and gain than at nominal 3.5-V design. The robust performance of the proposed PMIC is demonstrated.
Perceptual Quality Assessment of UGC Gaming Videos (2022)

In recent years, with the vigorous development of the video game industry, the proportion of gaming videos on major video websites like YouTube has dramatically increased. However, relatively little research has been done on the automatic quality prediction of gaming videos, especially on those that fall in the category of "User-Generated-Content" (UGC). Since current leading general-purpose Video Quality Assessment (VQA) models do not perform well on this type of gaming videos, we have created a new VQA model specifically designed to succeed on UGC gaming videos, which we call the Gaming Video Quality Predictor (GAME-VQP). GAME-VQP successfully predicts the unique statistical characteristics of gaming videos by drawing upon features designed under modified natural scene statistics models, combined with gaming specific features learned by a Convolution Neural Network. We study the performance of GAME-VQP on a very recent large UGC gaming video database called LIVE-YT-Gaming, and find that it both outperforms other mainstream general VQA models as well as VQA models specifically designed for gaming videos. The new model will be made public after paper being accepted.
Effects of albumin supplementation on microvascular permeability in septic patients (2002)

Albumin has a stabilizing effect on endothelium and helps maintain capillary permeability to macromolecules. Critically ill patients with sepsis may have profound hypoalbuminemia, but the effect of this hypoalbuminemia on microvascular permeability is unknown. To determine the degree and potential importance of this effect, we measured the transcapillary escape rate (TER) of (125)I-labeled albumin in 12 adult patients fulfilling American College of Chest Physicians/Society of Critical Care Medicine criteria for septic shock. We measured TER over a 90-min baseline period and then repeated these measurements immediately after the rapid infusion of 200 ml of 20% albumin. At baseline, patients had a mean serum albumin concentration of 10.3 +/- 3.8 g/l, which, at 30 min after the albumin infusion, was 18.5 +/- 3.7 g/l. The baseline TER was 6.7 +/- 1.5%/h, with a postinfusion TER of 6.4 +/- 2.1%/h (P = 0.550). Albumin supplementation sufficient to nearly double serum concentrations in profoundly hypoalbuminemic septic patients had no clinically significant effect in reducing microvascular permeability.
The no free lunch theorems: complexity and security (2003)

One of the main challenges for decision scientists in the 21st century will be managing systems of ever increasing complexity. As systems like electrical power grids, computer networks, and the software that controls it all grow increasingly complex, fragility, bugs, and security flaws are becoming increasingly prevalent and problematic. It is natural then to ask what consequences this growing complexity has on our ability to manage these systems. In this paper, we take a first step toward addressing this question with the development of the fundamental matrix, a framework for analyzing the broad qualitative nature of decision making. With the fundamental matrix we explain in a qualitative way many theorems and known results about optimization, complexity, and security. The simplicity of the explanations leads to new insights toward potential research directions. Like other "theories" dealing with broad fundamental properties, however, the fundamental matrix has certain limitations that make it largely descriptive. Thus, instead of claiming the last words our goal is to stimulate a dialog and debate that may one day lead to a prescriptive science of complexity.
Infectious Hepatitis (1967)

The identification of two types of infectious hepatitis with distinctive clinical, epidemiological, and immunological features provided an explanation for the occurrence of second attacks of the disease. One type resembled classical infectious hepatitis (IH); it was characterized by an incubation period of 30 to 38 days, a relatively short period of abnormal serum transaminase activity (3 to 19 days), a consistently abnormal thymol turbidity, and a high degree of contagion. The other type resembled serum hepatitis (SH); it was characterized by a longer incubation period (41 to 108 days), a longer period of abnormal transaminase activity (35 to 200 days) and a relatively normal thymol turbidity. Contrary to commonly accepted concepts, the SH type was moderately contagious. Patients with IH type were later proved to be immune to the same type. Patients with the SH type were not immune to the IH type infection.
Identification of the Electron-Diffusion Region during Magnetic Reconnection in a Laboratory Plasma (2008)

We report the first identification of the electron-diffusion region, where demagnetized electrons are accelerated to super-Alfvénic speed, in a reconnecting laboratory plasma. The width of the electron-diffusion region scales with the electron skin depth [ approximately (5.5-7.5)c/omega_{pe}] and the peak electron outflow velocity scales with the electron Alfvén velocity [ approximately (0.12-0.16)V_{eA}], independent of ion mass.
Renin‐Angiotensin System Blockade in Aortic Stenosis: Implications Before and After Aortic Valve Replacement (2020)

Aortic stenosis (AS) is a common valvular heart disease in the aging population that is characterized by a variable period of asymptomatic phase before development of symptoms and severe AS. Mortality and morbidity is substantial even after aortic valve replacement, in part related to persistent left ventricular hypertrophy, diastolic dysfunction, and heart failure. Renin-angiotensin system (RAS) blockade therapy is associated with modulation of adverse left ventricular remodeling, reduction in myocardial hypertrophy, and fibrosis, resulting in clinical improvements in patients with congestive heart failure There are emerging data to suggest benefit of RAS blockade in patients with AS before and after AVR with regard to potentially slower progression of aortic valve calcification, left ventricular mass and survival benefit in favor of RAS blockade group before AVR, and also survival benefit in patients after AVR. We review the available data to understand the role of RAS blockade before AVR and in patients undergoing surgical AVR and transcatheter AVR. There are significant survival advantages of RAS inhibition in patients with AS undergoing surgical AVR or transcatheter AVR. On the basis of existing literature, adequately powered randomized trials are needed to evaluate the role of RAS inhibition in patients with AS.
The surprising blindness in modern psychiatry: do guidelines really guide? (2016)

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Simple preoperative computed tomography image analysis shows good predictive performance for pathological vessel invasion in clinical stage IA non-small cell lung cancer (2012)

Vessel invasion had the greatest impact on recurrence in clinical stage IA non-small cell lung cancer. Our simple computed tomography image analysis showed good predictive performance for vessel invasion.
Paleogenomics of Echinoderms (2006)

Paleogenomics propels the meaning of genomic studies back through hundreds of millions of years of deep time. Now that the genome of the echinoid Strongylocentrotus purpuratus is sequenced, the operation of its genes can be interpreted in light of the well-understood echinoderm fossil record. Characters that first appear in Early Cambrian forms are still characteristic of echinoderms today. Key genes for one of these characters, the biomineralized tissue stereom, can be identified in the S. purpuratus genome and are likely to be the same genes that were involved with stereom formation in the earliest echinoderms some 520 million years ago.
Microstreaming induit par les oscillations non sphériques d'une bulle micrométrique (2018)

International audience
Multiple cutaneous and uterine leiomyomata resulting from missense mutations in the fumarate hydratase gene. (2005)

Multiple cutaneous and uterine leiomyomata (MCL) is an autosomal dominant disorder characterized by the development of benign smooth muscle tumours (leiomyomas) in the skin and uterus of affected women, and in the skin of affected men. In rare cases, MCL has been associated with a predisposition to the rare type II papillary renal cell cancer, also known as hereditary leiomyomatosis and renal cell cancer. The genetic locus for MCL has been mapped to chromosome 1q42.3-43 and subsequently, germline mutations in the fumarate hydratase (FH) gene have been identified. In addition, analysis of FH in some tumours of MCL patients revealed a second mutation inactivating the wild-type allele, suggesting that FH may function as a tumour suppressor gene. Here, we report two cases of MCL patients with FH mutations, designated as T287P and R190L. T287P represents a novel mutation of a highly conserved amino acid of the FH protein. In addition, a patient with an unusual clinical presentation of MCL was found to have the recurrent mutation, R190L, raising the possibility of incorporating FH sequencing as a diagnostic tool. Our findings extend the allelic series of mutations in FH and support its status as the underlying cause of MCL.
The Relevance of Interictal Bold Changes to Lateralize Seizure Focus Using Simultaneous EEG-fMRI (2015)

EEG-fMRI can be helpful additional tool in the pre-surgical work-up of refractory epilepsy particularly when lateralization with other modalities is conflicting or inconclusive.
Artificial Immune System Based Data Miner (2011)

The goal of this project is to show how to solve data mining classification problems using Clonal Selection Algorithm (CLONALG). A comparisons has been proposed between the CLONALG and other classification techniques to show the performance and the accuracy of it.