gebhart/patrepeval huggingface dataset:
Dust mite, cockroach, cat, and dog allergen concentrations in homes of asthmatic children in the northeastern United States: impact of socioeconomic factors and population density. (2002)

Home exposures to aeroallergens are an important environmental factor in allergic sensitization and in the development and exacerbation of asthma. We assessed variations in home concentrations of dust mite, cockroach, cat, and dog allergens in dust collected in the main living areas of asthmatics' homes by family income, mother's education, dwelling type, population density, household population density, and ethnicity in Connecticut and south-central Massachusetts. Dust samples were collected at the time of home interview in 999 homes as part of an ongoing longitudinal birth cohort study of 1,002 infants and their asthmatic siblings. The analysis employed lower and upper cut points for group 1 dust mite (> or = 2.0 microg/g and > or = 10 microg/g), cockroach (> or = 1.0 U/g and > or = 4.0 U/g), cat (> or = 1.0 microg/g and > or = 8.0 ug/g), and dog (> or = 2.0 microg/g and > or = 10.0 microg/g) allergens. Subject residences were geocoded to assess population density from the U.S. Census, and multiple logistic regression was used to control for confounding. The portion of homes at the lower cut point for dust mite, cockroach, cat, and dog allergens were 46.9%, 24.9%, 42.2%, and 35.6%, respectively; the upper cut point for each of the allergens was reached in 22.4%, 13.4%, 21.0%, and 22.9% of the homes, respectively. In all, 86.0% of the homes had at least one allergen at the lower cut point, and 58.0% had at least one allergen at the upper cut point. Forty-nine percent of the homes had two or more allergens at the lower cut point, and 19.7% had two or more allergens at the upper cut point. Higher education of the mother, higher household income, living in a single-family home in a less densely populated area with fewer people per room, and being a white household were associated with elevated dust mite, cat, and dog allergens and low cockroach allergen. In contrast, low income, living in a multifamily home in a high population density area with a higher occupancy rate per room, and being a Hispanic or black household were associated with elevated cockroach allergens and low concentrations of dust mite, cat, and dog allergens. Although the presence of an individual allergen is more likely associated with one or more socioeconomic or ethnic factors, most homes typically have multiple allergen burdens in excess of concentrations thought to be associated with sensitization and exacerbation of asthma. Mite and cockroach allergens have distinct and opposite associations with socioeconomic factors and population density.
Theory of Heterogeneity in Displacement Reactions (1997)

We investigate the effects of a heterogeneous distribution of affinity constants on association/dissociation and displacement reactions. Through a theoretical analysis, we show that the low-concentration limit of the reaction isotherm depends exclusively on the high-affinity tail of the distribution. If the high-affinity tail decays rapidly, the reaction follows the standard Langmuir isotherm. However, if the high-affinity tail decays slowly, the form of the isotherm crosses over to the Sips isotherm. The threshold for this crossover is different for association/dissociation and displacement reactions. These results have broad implications for the assessment of heterogeneity in displacement assays.
Conformation of a saturated 13-membered ring (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformation of a saturated 13-membered ringB. H. Rubin, M. Williamson, M. Takeshita, F. M. Menger, F. A. L. Anet, B. Bacon, and N. L. AllingerCite this: J. Am. Chem. Soc. 1984, 106, 7, 2088–2092Publication Date (Print):April 1, 1984Publication History Published online1 May 2002Published inissue 1 April 1984https://pubs.acs.org/doi/10.1021/ja00319a031https://doi.org/10.1021/ja00319a031research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Visually induced motion sickness (2008)

A Doctoral Thesis. Submitted in partial fulfillment of the requirements for the award of Doctor of Philosophy of Loughborough University.
A tuning transformer for the automatic adjustment of resonant loop antennas in RFID systems (2005)

Radio frequency identification (RFID) systems allow contactless communication between a small portable tag and a reader device. In this paper, we address the problem of performance degradations due to the detuning of resonant reader antennas in the widely used 13.56 MHz frequency band. A novel design of a tuning transformer for the adjustment of the center frequency of resonant loop antennas is proposed. The ferrite core of the transformer is premagnetized using an additional DC winding. The HF and DC windings are decoupled by an iron core. Besides the tuning, the transformer may also be used for impedance matching and for balancing an unbalanced signal. The function of the device was proven by network measurements. Key Words: Loop antenna, resonance tuning, RFID, tunable inductance.
How to Deploy a 10-km Interferometric Radio Telescope on the Moon with Just Four Tethered Robots (2022)

The Far-side Array for Radio Science Investigations of the Dark ages and Exoplanets (FARSIDE) is a proposed mission concept to the lunar far side that seeks to deploy and operate an array of 128 dual-polarization, dipole antennas over a region of 100 square kilometers. The resulting interferometric radio telescope would provide unprecedented radio images of distant star systems, allowing for the investigation of faint ra-dio signatures of coronal mass ejections and energetic particle events and could also lead to the detection of magnetospheres around exoplanets within their parent star&#x0027;s habitable zone. Simultaneously, FARSIDE would also measure the &#x2018;Dark Ages&#x0027; of the early Universe at a global 21-cm signal across a range of red shifts (z &#x007E;50-100). Each discrete antenna node in the array is connected to a central hub (located at the lander) via a communication and power tether. Nodes are driven by cold-operable electronics that continuously monitor (for 5 or more years) an extremely wide-band of frequencies (200 kHz to 40 MHz), which surpass the capabilities of Earth-based telescopes by two orders of magnitude. Achieving this ground-breaking capability requires a robust deployment strategy on the lunar surface, which is feasible with existing, high-TRL technologies (demonstrated or under active development) and is capable of delivery to the surface on next-generation commercial landers, such as Blue Origin&#x0027;s Blue Moon Lander. This paper presents an antenna packaging, placement, and surface deployment trade study that leverages recent advances in tethered mobile robots under development at NASA&#x0027;s Jet Propulsion Laboratory, which are used to deploy a flat, antenna-embedded, tape tether with optical communication and power transmission capabilities. We investigate the feasibility of deploying 4 separate 12-km tethers, each with 64 remotely powered electronics nodes, using just four rovers that trace out a large spiral pattern that is over 10-km in diameter, where each arm in the spiral is precisely laid out and aligned with respect to a global heading (NSEW) to provide dual polarization across the entire array. Further, we provide a detailed design for an instrument/antenna-embedded tether, detail its accommodation within and deployment from a two-wheeled rover, and show how the entire system can be packaged and deployed from a commercial lunar lander system.
Mechanism of Action and In Vitro Activity of 1′,3′-Dioxolanylpurine Nucleoside Analogues against Sensitive and Drug-Resistant Human Immunodeficiency Virus Type 1 Variants (1999)

(-)-Beta-D-1',3'-Dioxolane guanosine (DXG) and 2,6-diaminopurine (DAPD) dioxolanyl nucleoside analogues have been reported to be potent inhibitors of human immunodeficiency virus type 1 (HIV-1). We have recently conducted experiments to more fully characterize their in vitro anti-HIV-1 profiles. Antiviral assays performed in cell culture systems determined that DXG had 50% effective concentrations of 0.046 and 0.085 microM when evaluated against HIV-1(IIIB) in cord blood mononuclear cells and MT-2 cells, respectively. These values indicate that DXG is approximately equipotent to 2', 3'-dideoxy-3'-thiacytidine (3TC) but 5- to 10-fold less potent than 3'-azido-2',3'-dideoxythymidine (AZT) in the two cell systems tested. At the same time, DAPD was approximately 5- to 20-fold less active than DXG in the anti-HIV-1 assays. When recombinant or clinical variants of HIV-1 were used to assess the efficacy of the purine nucleoside analogues against drug-resistant HIV-1, it was observed that AZT-resistant virus remained sensitive to DXG and DAPD. Virus harboring a mutation(s) which conferred decreased sensitivity to 3TC, 2',3'-dideoxyinosine, and 2',3'-dideoxycytidine, such as a 65R, 74V, or 184V mutation in the viral reverse transcriptase (RT), exhibited a two- to fivefold-decreased susceptibility to DXG or DAPD. When nonnucleoside RT inhibitor-resistant and protease inhibitor-resistant viruses were tested, no change in virus sensitivity to DXG or DAPD was observed. In vitro drug combination assays indicated that DXG had synergistic antiviral effects when used in combination with AZT, 3TC, or nevirapine. In cellular toxicity analyses, DXG and DAPD had 50% cytotoxic concentrations of greater than 500 microM when tested in peripheral blood mononuclear cells and a variety of human tumor and normal cell lines. The triphosphate form of DXG competed with the natural nucleotide substrates and acted as a chain terminator of the nascent DNA. These data suggest that DXG triphosphate may be the active intracellular metabolite, consistent with the mechanism by which other nucleoside analogues inhibit HIV-1 replication. Our results suggest that the use of DXG and DAPD as therapeutic agents for HIV-1 infection should be explored.
Nanofabricated Racks of Aligned and Anchored DNA Substrates for Single-Molecule Imaging (2009)

Single-molecule studies of biological macromolecules can benefit from new experimental platforms that facilitate experimental design and data acquisition. Here we develop new strategies to construct curtains of DNA in which the molecules are aligned with respect to one another and maintained in an extended configuration by anchoring both ends of the DNA to the surface of a microfluidic sample chamber that is otherwise coated with an inert lipid bilayer. This "double-tethered" DNA substrate configuration is established through the use of nanofabricated rack patterns comprised of two distinct functional elements: linear barriers to lipid diffusion that align DNA molecules anchored by one end to the bilayer and antibody-coated pentagons that provide immobile anchor points for the opposite ends of the DNA. These devices enable the alignment and anchoring of thousands of individual DNA molecules, which can then be visualized using total internal reflection fluorescence microscopy under conditions that do not require continuous application of buffer flow to stretch the DNA. This unique strategy offers the potential for studying protein-DNA interactions on large DNA substrates without compromising measurements through application of hydrodynamic force. We provide a proof-of-principle demonstration that double-tethered DNA curtains made with nanofabricated rack patterns can be used in a one-dimensional diffusion assay that monitors the motion of quantum dot-tagged proteins along DNA.
Polyethylene with extremely narrow polydispersity obtained from the new catalyst systems Nb(η5-C5Me5)(η4-diene)Cl2–MAO and Nb(η5-C5Me5)(η4-diene)2–MAO (1994)

Niobium complexes Nb(η5-C5Me5)(η4-diene)Cl2(diene = buta-1,3-diene 1a, isoprene 1b, or 2,3-dimethylbuta-1,3-diene 1c) and Nb(η5-C5Me5)(η4–2,3-dimethylbuta-1,3-diene)23 in the presence of a large excess of methylaluminoxane (MAO)were found to be active catalysts for the polymerization of ethylene to give polyethylen with narrow polydispersities (Mw/Mn as low as 1.05).
Dispersions of Nanocrystalline Cellulose in Aqueous Polymer Solutions: Structure Formation of Colloidal Rods (2012)

The steady-state shear and linear viscoelastic deformations of semidilute suspensions of rod-shaped nanocrystalline cellulose (NCC) particles in 1.0% hydroxyethyl cellulose and carboxymethyl cellulose solutions were investigated. Addition of NCC at the onset of semidilute suspension concentration significantly altered the rheological and linear viscoelastic properties of semidilute polymer solutions. The low-shear viscosity values of polymers solutions were increased 20-490 times (depending on polymer molecular weight and functional groups) by the presence of NCC. NCC suspensions in polymer solutions exhibited yield stresses up to 7.12 Pa. Viscoelasticity measurements also showed that NCC suspended polymer solutions had higher linear elastic moduli than the loss moduli. All of those results revealed the gel formation of NCC particles and presence of internal structures. The formation of a weak gel structure was due to the nonadsorbing macromolecules which caused the depletion-induced interaction among NCC particles. A simple interaction energy model was used to show successfully the flocculation of NCC particles in the presence of nonadsorbing polymers. The model is based on the incorporation of the depletion interaction term between two parallel plates into the DLVO theory for cubic prismatic rod shaped NCC particles.
Salivary cortisol, 17β‐estradiol, progesterone, dehydroepiandrosterone, and α‐amylase in patients with burning mouth syndrome (2012)

In conclusion, patients with BMS showed significantly higher levels of cortisol in UWS and of 17β-estradiol in SWS compared with controls.
Rice Chalky Ring Formation Caused by Temporal Reduction in Starch Biosynthesis during Osmotic Adjustment under Foehn-Induced Dry Wind (2014)

Foehn-like extreme hot and dry wind conditions (34°C, >2.5 kPa vapor pressure deficit, and 7 m s(-1)) strongly affect grain quality in rice (Oryza sativa L.). This is a current concern because of the increasing frequency and intensity of combined heat and water-deficit stress under climate change. Foehn-induced dry wind conditions during the grain-filling stage increase ring-shaped chalkiness as a result of spatiotemporal reduction in starch accumulation in the endosperm, but kernel growth is sometimes maintained by osmotic adjustment. Here, we assess the effects of dry wind on chalky ring formation in environmentally controlled growth chambers. Our results showed that hot and dry wind conditions that lasted for >24 h dramatically increased chalky ring formation. Hot and dry wind conditions temporarily reduced panicle water potential to -0.65 MPa; however, kernel growth was maintained by osmotic adjustment at control levels with increased transport of assimilate to the growing kernels. Dynamic tracer analysis with a nano-electrospray-ionization Orbitrap mass spectrometer and quantitative polymerase chain reaction analysis revealed that starch degradation was negligible in the short-term treatment. Overall expression of starch synthesis-related genes was found to be down-regulated at moderately low water potential. Because the events observed at low water potential preceded the packing of starch granules in cells, we concluded that reduced rates of starch biosynthesis play a central role in the events of cellular metabolism that are altered at osmotic adjustment, which leads to chalky ring formation under short-term hot and dry wind conditions.
Lipid production by Yarrowia lipolytica grown on biodiesel-derived crude glycerol: optimization of growth parameters and their effects on the fermentation efficiency (2016)

<italic>Yarrowia lipolytica</italic>, a well-known oleaginous strain for single cell oil (SCO) production was grown in nitrogen-limited flask cultures.
Pathological Features and Imaging Findings in Pancreatic Carcinoma In Situ (2021)

In LP type PCIS, intraductal infiltration of the MPD occurs frequently. There may be multiple lesions, and lesions may recur in the remnant pancreas. Long-term strict follow-up assessments should be implemented for LP type PCIS.
Hybrid vector designs to control the delivery, fate and expression of transgenes (2000)

One of the greatest challenges to gene therapy is the targetting of gene delivery selectively to the sites of disease and regulation of transgene expression without adverse effects. Ultimately, the successful realization of these goals is dependent upon improvements in vector design. Over the years, viral vector design has progressed from various types of replication-defective viral mutants to replication-conditioned viruses and, more recently, to 'gutted' and hybrid vectors, which have, respectively, eliminated expression of non-relevant or toxic viral genes and incorporated desired elements of different viruses so as to increase the efficacy of gene delivery in vivo. This review will focus on the different viral and cellular elements which have been incorporated into virus vectors to: improve transduction efficiencies; alter the entry specificity of virions; control the fate of transgenes in the host cells; and regulate transgene expression.
Thermal Degradation of Polystyrene. 3. A Reappraisal (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal Degradation of Polystyrene. 3. A ReappraisalG. Gordon Cameron, Janet M. Meyer, and Ian T. McWalterCite this: Macromolecules 1978, 11, 4, 696–700Publication Date (Print):July 1, 1978Publication History Published online1 May 2002Published inissue 1 July 1978https://pubs.acs.org/doi/10.1021/ma60064a016https://doi.org/10.1021/ma60064a016research-articleACS PublicationsRequest reuse permissionsArticle Views222Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tyrosine Residues 951 and 1059 of Vascular Endothelial Growth Factor Receptor-2 (KDR) Are Essential for Vascular Permeability Factor/Vascular Endothelial Growth Factor-induced Endothelium Migration and Proliferation, Respectively (2001)

Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) exerts its multiple functions by activating two receptor tyrosine kinases, Flt-1 (VEGFR-1) and KDR (VEGFR-2), both of which are selectively expressed on primary vascular endothelium. To dissect the respective signaling pathways and biological functions mediated by these receptors in primary endothelial cells with two receptors intact, we, recently developed chimeric receptors (EGDR and EGLT) in which the extracellular domain of the epidermal growth factor receptor was fused to the transmembrane domain and intracellular domain of KDR and Flt-1, respectively. With these fusion receptors, we have shown that KDR is solely responsible for VPF/VEGF-induced human umbilical vein endothelial cell (HUVEC) proliferation and migration, whereas Flt-1 showed an inhibitory effect on KDR-mediated proliferation but not migration. To further characterize the VPF/VEGF-stimulated HUVEC proliferation and migration here, we have created several EGDR mutants by site-directed mutagenesis. We show that tyrosine residues 1059 and 951 of KDR are essential for VPF/VEGF-induced HUVEC proliferation and migration, respectively. Furthermore, the mutation of tyrosine 1059 to phenylanaline results in the complete loss of KDR/EGDR-mediated intracellular Ca(2+) mobilization and MAPK phosphorylation, but the mutation of tyrosine 951 to phenylanaline did not affect these events. Our results suggest that KDR mediates different signaling pathways for HUVEC proliferation and migration and, moreover, intracellular Ca(2+) mobilization and MAPK phosphorylation are not essential for VPF/VEGF-induced HUVEC migration.
An Immunohistochemistry-Based Study on Aquaporin (AQP)-1, 3, 4, 5 and 8 in the Parotid Glands, Submandibular Glands and Sublingual Glands of Sj^|^ouml;gren^|^rsquo;s Syndrome Mouse Models Chronically Administered Cevimeline (2013)

Cevimeline is a muscarinic agonist that promotes saliva secretion and is used to treat Sjögren's syndrome (SS), an autoimmune disorder in which the exocrine glands that produce saliva are destroyed. Cevimeline is thought to affect the composition of saliva in part by regulating the localization of aquaporins (AQPs). In this study, we investigated the effects of chronic Cevimeline administration in the salivary glands of SS mice on the immunohistochemical localization of aquaporin (AQP)-1, 3, 4, 5 and 8. We used Cevimeline-untreated SS mice, treated SS mice, discontinued SS mice and untreated normal mice. AQP-5 was found in the apical and lateral membranes of acinar cells in the parotid and submandibular glands of cevimeline-treated SS mice and untreated normal mice. Saliva secretion and AQP-5 localization were sustained in SS mice who were chronically administered Cevimeline and at four weeks after discontinuation. Unlike AQP-5, the localization of AQP-1, 3, 4 and 8 were not affected by Cevimeline administration. Our findings demonstrated that administration of Cevimeline maintains the proper localization of AQP-5 in the acinar cells of the salivary gland, which may promote salivation in chronically treated SS mice. Clinically, this suggests that chronic Cevimeline administration may be useful therapeutically for SS patients suffering from a decrease in saliva secretion by improving the disordered AQP-5 localization.
LSH based outlier detection and its application in distributed setting (2011)

In this paper, we give an approximate algorithm for distance based outlier detection using Locality Sensitive Hashing (LSH) technique. We propose an algorithm for the centralized case wherein the entire dataset is locally available for processing. However, in case of very large datasets collected from various input sources, often the data is distributed across the network. Accordingly, we show that our algorithm can be effectively extended to a constant round protocol with low communication costs, in a distributed setting with horizontal partitioning.