gebhart/patrepeval huggingface dataset:
A Phase I/II Multicenter, Safety and Efficacy Study of Combination Treatment with Melphalan, Arsenic Trioxide and Vitamin C (MAC) in Patients with Relapsed or Refractory Multiple Myeloma. (2004)

Abstract Background: An urgent need exists for new treatments to overcome chemoresistance in MM patients. Recent in vitro and In vivo studies in our laboratory show that arsenic trioxide (ATO) can sensitize chemoresistant MM cells to melphalan-induced cytotoxic effects. Pre-clinical studies also show the most profound anti-MM effects when ATO, ascorbic acid and melphalan are used in combination compared with the effects observed when the drugs are used alone or combinations of any two of these agents. Based on encouraging results from a pilot study1, a larger, multicenter trial was recently started. Methods: MM patients who showed relapse after responding to first-line chemotherapy and/or having proved to be refractory to chemotherapy are enrolled. Patients received a loading dose of ATO at 0.25 mg/kg IV followed by ascorbic acid 1 g IV days 1–4 of week 1 of each six-week cycle. ATO/ascorbic acid was given twice-weekly for the next 4 weeks of each cycle. Low-dose melphalan (0.10 mg/kg) was administered orally for the first 4 days of each cycle. Patients received a maximum of 6 cycles followed by weekly maintenance treatment with weekly ATO followed by ascorbic acid. The primary objectives of this study are to determine response rate and safety and tolerability of MAC therapy. Results: Twenty patients have received at least one treatment cycle. Preliminary data show that eight (4 PR, 4 MR) of the 14 evaluable patients (57%) had an objective response, an additional three patients achieved stable disease, resulting in a total of 11 patients (79%) with disease control. Since responses were seen after 2 to 5 treatment cycles, it is possible that some patients with stable disease may experience additional disease response. Seven of the eight responding patients had failed two or more treatments: five patients had received prior thalidomide therapy, two had received melphalan and bortezomib, and two patients had undergone autologous peripheral stem cell transplantation. Of the six patients who have now completed the maximal numbers of cycles, four achieved PR, one MR, and one SD. The regimen was well tolerated with few significant side effects reported; mild cytopenias were reported as reversible. Conclusions: These preliminary results in this treatment group of heavily pre-treated MM patients who had either relapsed or were refractory to standard and/or investigational multiple myeloma treatments suggests that the MAC treatment regimen (1) shows efficacy using a low dose of melphalan supporting the preclinical evidence that ATO can sensitize tumors to chemotherapy; (2) is well tolerated; (3) may require multiple cycles before response.
Metal ion nmr application to biological systems (1986)

Publisher Summary This chapter discusses the biological importance of metal ion nuclear magnetic resonance (NMR). Inorganic elements have a multitude of functions in biological systems, such as carriers of ionic signals, triggering of proteins, formation of structures, electron transport, and enzyme catalysis. All essential elements in biological systems and all elements of the periodic table have at least one potentially valuable isotope for NMR studies. This is because the NMR sensitivity of many biologically interesting nuclei is very low. NMR parameters are generally dependent upon the chemical nature of the nuclear environment and on its structure and dynamics. Thus, NMR spectroscopy may be used to identify and characterize metal ion binding sites on biological macromolecules and how these change during the course of biochemical reactions. The possibility of using NMR to determine metal ion populations of individual binding sites on a multisite protein is not matched by many other physical techniques. Metal ion NMR also makes it possible to address such elusive questions as cooperatively or anticooperativity of ion binding. As the relaxation of quadrupolar nuclei usually is caused by fluctuating electrical field gradients at the site of the nucleus, NMR studies can provide insight into ion binding to poly electrolytes, discriminate between nonspecific and specific ion binding, and are in general useful for testing theoretical models of ion binding
Extreme ultraviolet photoabsorption spectra of the Ce VI–Ce X isonuclear sequence (2008)

The extreme ultraviolet photoabsorption spectra of cerium from five to nine times ionized have been recorded in the 70–120 eV region using the dual laser plasma technique. These represent the highest ion stages observed to date using this method. The spectra below 115 eV were found to be dominated by 4d → 5p transitions from the ground configurations of these ions and the resulting lines were identified with the aid of Hartree–Fock with configuration interaction calculations. Some features due to 4d → 5p transitions from the metastable configurations of ions Ce VI–Ce X were also observed.
Extensibility and Reuse in an Agent-Based Dialogue Model (2006)

Most existing dialogue systems have been developed specifically for some predefined task domain(s), thus the issues of extensibility and reuse of the dialogue model are often not given much attention. In this paper, we describe our work on extending an existing agent-based dialogue model for e-mail management to further handle the calendar task domain. We discuss how our approach can achieve modularity of the dialogue model at the level of agent plans, facilitating the reuse of discourse-level plans and enabling the extension of the dialogue model to cover different application domains
ChemInform Abstract: Regioselective Synthesis of 1‐Alkyl‐1‐phenylhydrazines, 2‐Alkyl‐1‐phenylhydrazines, and 1,2‐Dialkyl‐1‐phenylhydrazines. (1990)

Abstract The hydrazonophosphorane (II), generated by reaction of the hydrazinophosphonium bromide (I) with BuLi, is treated with the alkyl halides (III) to produce the 1‐alkyl‐2‐phenylhydrazines (V) after hydrolysis of the corresponding phosphonium halides (IV).
Depth from Stereo and Polarization of Opaque Non-Lambertian Surfaces (2017)

This paper presents a new approach to depth from stereo in scenes with non-Lambertian surfaces. While these surfaces usually prove to be hard to incorporate in photo-consistency energy minimization, we retrieve additional information about their surface normals from applying a polarization-based approach that computes the degree and angle of polarization at each pixel. Therefore, we set up a stereo camera rig that captures four different rotations of a linear polarizer simultaneously for each camera. While most existing polarization-based approaches to shape reconstruction require a setup with known lighting, our approach uses arbitrary unpolarized illumination. We describe a regularization-based stereo approach that constrains specular surface normals in the scene to lie in the plane of their observed angle of polarization. We derive the mathematical foundations of this approach and present results on virtually generated stereo and real-world stereo imagery.
Laser structuring and modification of surfaces for chemical and medical micro components (2003)

In the production of micro devices for applications in chemistry, biotechnology and medical technologies surface properties become more and more important. The microscale topography and surface chemistry have influence on wetting properties and cell behavior. Therefore the design of material surface determines the success of artificial devices in contact with biological systems. For applications in the field of medical implants laser technologies have been developed for micro structuring of polymers to modify the surface properties with respect to wettability and controlled cell growth. The technology is based on excimer laser treatment of polymer surfaces using laser wavelength 193 nm (ArF) with different fluences and cumulated energies. Depending on the processing parameters and examined polymers either hydrophobic or hydrophilic surfaces can be increased. The water contact angle of polydimethylsiloxane (PDMS) for example can be increased from 113&deg; to approx. 150&deg; so that the surface exhibits the so called lotus effect. The laser generated micro patterns reveal influence on cell density and cell distribution which can be used for cell guidance. Results for cell growing experiments are shown for different polymers.
SPACE-TIME BLOCK CODES WITH MAXIMAL DIVERSITY IN OFDM-BASED SYSTEMS (2009)

In this paper, Orthogonal Space Time Block Coding (OS-TBC) is combined with linear precoding matrices to improve the exploitation of the different diversities for a multicarrier transmission. The linear precoding matrices based on Hadamard construction are proposed where a simple linear de-precoder can be chosen at the receiver part which performs closely to the Maximum Likelihood (ML) global precoded OSTBC decoder. The system is generalized to different numbers of transmit antennas and different sizes of precoding matrices. Performance results have been obtained in theoretical and real channel environments. It is shown that the combined scheme efficiently exploits the space, time and frequency diversities while using a linear decoder. This system leads to an OSTBC with maximal diversity for more than two antennas when a Zero Forcing (ZF) or a Minimum Mean Square Error (MMSE) equalizer is chosen. 1
Low-Alcohol Beers: Contribution to Blood-Ethanol Concentration and Its Elevation above the UK Legal Limit after 'Topping-up' (2009)

Low-alcohol beers make a significant contribution to blood-ethanol concentration and can increase it above the UK legal limit. Their use as a 'top-up' should be discouraged. Low-alcohol beers have a place as a substitute for normal-strength beverages as a strategy for decreasing alcohol consumption in general and in countries where low legal alcohol limits are in force or being contemplated.
Serious Infections in Elderly Patients with Diabetes Mellitus (2005)

The elevated serum glucose levels associated with diabetes mellitus (DM) alter host immune responses, resulting in a well-documented increase in the predisposition to infectious processes. Furthermore, the cumulative effect of age-related immune senescence, superimposed on this enhanced risk of infections, can lead to serious and life-threatening infections in elderly patients with DM. Because infection associated with aging can frequently present in a subtle and atypical manner, prompt recognition of infection and treatment with appropriate empirical broad-spectrum antimicrobial agents, in conjunction with surgical intervention, is often necessary to eradicate such infections. Common sites of serious infection associated with DM include the head and neck, biliary tract, and urinary tract, as well as the skin, soft tissue, and bony structures of the feet in particular.
miR-125b regulates differentiation and metabolic reprogramming of T cell acute lymphoblastic leukemia by directly targeting A20 (2016)

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic malignancy. Although it has been reported that overexpression of miR-125b leads to T-ALL development, the underlying mechanisms of miR-125b action are still unclear. The goal of this study is to delineate the role of miR-125b in T-ALL development. We found that miR-125b is highly expressed in undifferentiated leukemic T cells (CD4-negative) while its expression is low in differentiated T cells (CD4-positive). Overexpression of miR-125b increased the CD4-negative population in T cells, whereas depletion of miR-125b by miR-125b-sponge decreased the CD4-negative cell population. We identified that A20 (TNFAIP3) is a direct target of miR-125b in T cells. Overexpression of miR-125b also increased glucose uptake and oxygen consumption in T cells through targeting A20. Furthermore, restoration of A20 in miR-125b-overexpressing cells decreased the CD4-negative population in T cell leukemia, and decreased glucose uptake and oxygen consumption to the basal level of T cells transfected with vector. In conclusion, our data demonstrate that miR-125b regulates differentiation and reprogramming of T cell glucose metabolism via targeting A20. Since both de-differentiation and dysregulated glucose metabolism contribute to the development of T-cell leukemia, these findings provide novel insights into the understanding and treatment of T-ALL.
Methylation analysis of the carbohydrate portion of carcinoembryonic antigen. (1976)

The carbohydrate structural units of carcinoembryonic antigen samples isolated from four different tumors were quantitated using gas chromatography-mass spectrometery after methylation and subsequent conversion to their alditol acetates. Different carcinoembryonic antigen preparations showed some quantitative but no qualitative differences in the structural units present. The results indicate that a large portion of the fucose residues in the glycoprotein were linked to N-acetylglucosamine and that most of the branching mannose residues were probably linked to three N-acetylglucosamine residues.
A Max Kernel For Text-Independent Speaker Verification Systems (2006)

In this paper, we present a principled SVM based speaker verification system. A general approach to compute two sequences of frames is developed that enables the use of any kernel at the frame level. An extension of this approach using the Max operator is then proposed. The new system is compared to state-of-the-art GMM and other SVM based systems found in the literature on the Polyvar database. The new system outperforms, most of the time, the other systems, statistically significantly. 1
Pilot trial of tumor‐specific peptide vaccination and continuous infusion interleukin‐2 in patients with recurrent Ewing sarcoma and alveolar rhabdomyosarcoma: An inter‐institute NIH study† (2002)

Peptide vaccination as administered in this trial did not alter the dismal clinical outcome for patients with recurrent pediatric sarcomas. Future trials of tumor vaccines in this population should target patient populations with improved immune competence and smaller tumor burdens. Furthermore, optimization of the antigen presenting cell populations may be important for inducing immune responses to peptide antigens.
MarZIC: A Marginal Mediation Model for Zero-Inflated Compositional Mediators with Applications to Microbiome Data (2022)

When analyzing the zero-inflated microbiome composition as the mediators, MarZIC approach has better performance than standard causal mediation analysis approaches and existing competing approach.
Identifying Opportunities to Enhance Environmental Cleaning in 23 Acute Care Hospitals (2007)

We identified significant opportunities in all participating hospitals to improve the cleaning of frequently touched objects in the patient's immediate environment. The information obtained from such assessments can be used to develop focused administrative and educational interventions that incorporate ongoing feedback to the environmental services staff, to improve cleaning and disinfection practices in healthcare institutions.
Regulation of RNA Polymerase III Transcription Involves SCH9-dependent and SCH9-independent Branches of the Target of Rapamycin (TOR) Pathway (2009)

Maf1 is a conserved repressor of transcription that functions at the downstream end of multiple nutrient and stress signaling pathways. How these different signaling pathways converge on Maf1 is not known. Previous work in yeast indicates that protein kinase A (PKA) regulates RNA polymerase (pol) III transcription, in part, by phosphorylating multiple sites in Maf1. Here we present additional evidence for this view and show that a parallel nutrient and stress-sensing pathway involving Sch9, an homologous kinase to metazoan S6 kinase, targets Maf1 at a subset of PKA sites. Using ATP analog-sensitive alleles of PKA and Sch9, we find that these two kinases account for the bulk of the phosphorylation on consensus PKA sites in Maf1. Deletion of Sch9 reduces RNA pol III transcription in a Maf1-dependent manner, yet the cells remain susceptible to further repression by rapamycin and other treatments. Because the rapamycin-sensitive kinase activity of the TORC1 complex is necessary for Sch9 function in vivo and in vitro, our results show that transcriptional regulation of RNA pol III and the coordinate control of ribosomal protein genes can be achieved by Sch9-dependent and -independent branches of the target of rapamycin (TOR) signaling pathway.
Characteristics of top coal fall in front of face support in longwall: A case study (2020)

Top coal fall in front of face support severely affects the safety and productivity in mechanized longwall mining. This paper presents a discontinuous numerical analysis on the important characteristics of the fall such as abutment stress, material failure, and fall mode. A top coal fall model is validated against site observation and past numerical and empirical studies. The numerical results provide further evidence confirming that horizontal stress relaxation, vertical stress concentration, and strength and structure of coal seam control the failure of top coal ahead of support. Top coal fall in longwall mining with large caving height is found in “stress caving” mode or, in other words, “horizontal stress-driven guttering” mechanism. A pre-existing fault running into a mined-out area can facilitate the occurrence of face spall but may not lead to top coal fall. The results of this study are particularly helpful to engineers in developing proper remedy or prevention solutions to top coal/roof fall incidents.
Blood pressure reduction programs for African American women (2005)

African Americans (AA) have a higher prevalence of hypertension and worse cardiovascular and renal outcomes than white Americans. The purpose of this study was to evaluate blood pressure (BP) reduction effectiveness of a two tiered, culturally sensitive, cardiovascular disease (CVD) risk reduction program in moderate and low risk groups of AA women. Participants were assigned to one of two interventions based on the number of CVD risk factors present. The first tier, low level intervention, subjects were AA ≥ 19 years old with a BP ≥ 120/80 who attended free 10-week CVD risk reduction classes led by AA peer health educators. BP and weight were checked weekly. The second tier, higher risk / intensive intervention, subjects were AAs ≥ 40 years with a BP ≥ 120/80 and 1+ additional CVD risk factor(s). These subjects received evaluation, instruction, and follow up with a Nurse Practitioner, Health Educator, and Dietitian in addition to participation in the peer class series. Subjects from both tiers were referred back to their primary care providers for all medication management as needed.
Reductive functionalization of CO2 with amines: an entry to formamide, formamidine and methylamine derivatives (2014)

Unprecedented transformations have been developed over the last years to convert amines to formamides, formamidines and methylamines, in the presence of CO<sub>2</sub> as a reagent. These emerging technologies are reviewed in this perspective and the opportunities and challenges facing the practical use of CO<sub>2</sub> in the production of nitrogen molecules are discussed.
cis-2,4,6,8-Tetranitro-1H,5H-2,4,6,8-tetraazabicyclo[3.3.0]octane, the energetic compound `bicyclo-HMX' (2002)

The title compound, C4H6N8O8, represents the energetic mol­ecule commonly called `bi­cyclo-HMX'. It was synthesized because it was expected to be denser than the powerful energetic material HMX, and thus exhibit improved energetic performance. X-ray diffraction analysis showed that this mol­ecule was actually slightly less dense than HMX.
Cryogenic Tank Modeling for the Saturn AS-203 Experiment (2006)

A computational fluid dynamics (CFD) model is developed for the Saturn S-IVB liquid hydrogen (LH2) tank to simulate the 1966 AS-203 flight experiment. This significant experiment is the only known, adequately-instrumented, low-gravity, cryogenic self pressurization test that is well suited for CFD model validation. A 4000-cell, axisymmetric model predicts motion of the LH2 surface including boil-off and thermal stratification in the liquid and gas phases. The model is based on a modified version of the commercially available FLOW3D software. During the experiment, heat enters the LH2 tank through the tank forward dome, side wall, aft dome, and common bulkhead. In both model and test the liquid and gases thermally stratify in the low-gravity natural convection environment. LH2 boils at the free surface which in turn increases the pressure within the tank during the 5360 second experiment. The Saturn S-IVB tank model is shown to accurately simulate the self pressurization and thermal stratification in the 1966 AS-203 test. The average predicted pressurization rate is within 4% of the pressure rise rate suggested by test data. Ullage temperature results are also in good agreement with the test where the model predicts an ullage temperature rise rate within 6% of the measured data. The model is based on first principles only and includes no adjustments to bring the predictions closer to the test data. Although quantitative model validation is achieved or one specific case, a significant step is taken towards demonstrating general use of CFD for low-gravity cryogenic fluid modeling.
Attitudes toward Counterfeit Products and Generation Differentia (2012)

Given growth in international trade in counterfeit products and whereas Consumers are the actual forces behind this counterfeiting trade, so, the study focuses on the demand side of counterfeiting, identifying and examining factors influencing on attitude of consumers of non-deceptive counterfeiting in terms of differences generations in Iran, second most populous country among the countries of Middle East. In this study, based on the four generation and the revolution in Iran, the generations are divided into two generations: combination generation and Y generation and also, Conceptual framework of the study emphasizes that Perceived Risk, Risk Averseness, Price-Quality preference, Subjective Norm, Integrity, Personal Gratification could affect on attitudes toward counterfeit products. Results of SEM from samples of combination generation (52.43%) and Y generation (47.57) indicate that perceived risk and risk averseness have negative impact on attitudes toward counterfeit products and Personal Gratification no impact on it under both of generations but other variables have differences impacts on attitudes. Also in both of generations, the results indicated that attitudes toward counterfeit products are positively related to behavior intentions. Drawing on the results of the research, the researchers suggest that it may be necessary for the marketing practices for these two generations differ.
Planar Schottky Microwave Diodes on 4H-SiC (2005)

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