gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Structure of 1,5,9‐Trinitrobishomopentaprismane (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Performance of Low-Complexity Greedy Scheduling Policies in Multi-Channel Wireless Networks: Optimal Throughput and Near-Optimal Delay (2012)

In this paper, we focus on the scheduling problem in multi-channel wireless networks, e.g., the downlink of a single cell in fourth generation (4G) OFDM-based cellular networks. Our goal is to design efficient scheduling policies that can achieve provably good performance in terms of both throughput and delay, at a low complexity. While a recently developed scheduling policy, called Delay Weighted Matching (DWM), has been shown to be both rate-function delay-optimal (in the many-channel many-user asymptotic regime) and throughput-optimal (in general non-asymptotic setting), it has a high complexity O(n5), which makes it impractical for modern OFDM systems. To address this issue, we first develop a simple greedy policy called Delay-based Queue-Side-Greedy (D-QSG) with a lower complexity O(n3), and rigorously prove that D-QSG not only achieves throughput optimality, but also guarantees near-optimal rate-function-based delay performance. Specifically, the rate-function attained by DQSG for any fixed integer threshold b > 0, is no smaller than the maximum achievable rate-function by any scheduling policy for threshold b-1. Further, we develop another simple greedy policy called Delay-based Server-Side-Greedy (D-SSG) with an even lower complexity O(n2), and show that D-SSG achieves the same performance as D-QSG. Thus, we are able to achieve a dramatic reduction in complexity (from O(n5) of DWM to O(n2)) with a minimal drop in the delay performance. Finally, we conduct numerical simulations to validate our theoretical results in various scenarios. The simulation results show that our proposed greedy policies not only guarantee a near-optimal rate-function, but also empirically are virtually indistinguishable from the delay-optimal policy DWM.
Construction and Performance Characterization of α-Fe2O3/rGO Composite for Long-Cycling-Life Supercapacitor Anode (2017)

Thumb-ring-like α-Fe2O3 and reduced graphene oxide (rGO) composites, α-Fe2O3/rGO, have been synthesized via a simple hydrothermal method accompanied by surface potential tuning. The obtained samples exhibit good electrochemical performance with a wide negative potential window of −1–0.2 V vs Ag/AgCl when serving as supercapacitor electrodes. There is only about 10% decay after 11 000 cycles of galvanostatic charge–discharge (GCD) test. After a few tens of cycles of cycling activity, the capacitance achieved a stable value of 255 F g–1 at 0.5 A g–1 and 174 F g–1 at 5 mV s–1; 75% of the capacitance was retained when the scan rate increased to 200 mV s–1, indicating satisfactory power density. Most attractively, along with cycling, the α-Fe2O3 particles begin to be well-wrapped by rGO gradually from prior stacked structure, which is supposed to be the key factor for the exceptional high cycling stability.
Supplementary Figures from Optoacoustic Detection of Early Therapy-Induced Tumor Cell Death Using a Targeted Imaging Agent (2023)

&lt;p&gt;Supplementary figures 1 - 4. Caption for video file.&lt;/p&gt;
Ternary Organic Blend Approaches for High Photovoltaic Performance in Versatile Applications (2019)

Abstract Ternary blend approaches are demonstrated as a universal means to improve overall performance of organic photovoltaics (OPVs) in both indoor and outdoor conditions. A comparative study on two donors:one acceptor (2D:1A) and one donor:two acceptors (1D:2A) ternary blends shows that both approaches are universally effective for indoor and outdoor operation; the 1D:2A devices incorporating a nonfullerene acceptor (NFA) benefit from less charge recombination and higher power conversion efficiencies (PCEs) for various irradiation conditions, while the performance of the 2D:1A blends depends on the emission spectrum of the incident light source. The synergistic merits of NFAs and ternary structure in the 1D:2A ternary OPVs secure better performance and generality regardless of the incident lighting. A combination of experimental and theoretical analyses unveils that NFAs optimize packing and arrangement of molecules to build efficient cascade ternary junctions in the 1D:2A blends, which can be important design guidelines for the third component in ternary OPVs. The optimized 1D:2A ternary OPV exhibits a new record PCE of 25.6% under a 200 lux light‐emitting diode (LED) and 26.4% under a 1000 lux LED, and superior durability under industrial relevant thermal stress, suggesting new opportunities in diverse practical applications challenging the currently dominant PV technologies.
Altered Expression of Circulating MicroRNA in Plasma of Patients with Primary Osteoarthritis and In Silico Analysis of Their Pathways (2014)

We identified 12 miRNA in the plasma of patients with primary OA. Specific miRNA that are altered in the disease could be released into plasma, either due to cartilage damage or to an inherent cellular mechanism. Several miRNA could regulate genes and pathways related with development of the disease; eight of these circulating miRNA are described, to our knowledge, for first time in OA.
5‐Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure‐induced respiratory arrest (2016)

Our data suggest that S-IRA is the primary event leading to death incurred in most DBA/1 and some C57BL/6J mice during PTZ-evoked seizures. Suppression of S-IRA by 5-HTP suggests that 5-HT transmission contributes to the pathophysiology of S-IRA, and that 5-HTP, an over-the-counter supplement available for human consumption, may be clinically useful in preventing SUDEP.
Changes in Drug Utilization during a Gap in Insurance Coverage: An Examination of the Medicare Part D Coverage Gap (2011)

A lack of financial assistance after reaching the gap spending threshold was associated with a doubling in discontinuing essential medications but not switching drugs in 2006 and 2007. Blunt cost-containment features such as the coverage gap have an adverse impact on drug utilization that may conceivably affect health outcomes.
ESTROGEN RECEPTOR-BETA GENOTYPE, SEVEN IMMUNOHISTOCHEMICAL MARKERS, AND HUMAN LUNG CANCER (2010)

Lung cancer is the leading cause of cancer death in the United States. However, few new and effective treatments are available for lung cancer. A comprehensive understanding of the multiple signaling pathways that lead to tumor growth is a prerequisite for more effective and targeted cancer treatments. The purpose of this research was to investigate the relationship between proteins [hepatocypte growth factor (HGF), c-Met, and estrogen receptor-beta (ER-beta)] and gene expression of ER-beta (ESR2) and lung cancer survival along with identifying meaningful expression patterns of seven biomarkers [HGF, c-Met, ER-alpha, ER-beta, progesterone receptor (PR), aromatase, and epidermal growth factor receptor (EGFR)]. We used immunohistochemistry to quantify the expression of seven proteins in primary lung tumor tissues from the Lung Cancer Specialized Program of Research Excellence substudy (N=204). The generalized linear mixed model approach, which controlled for sample type (tissue microarray vs. whole-section), showed high HGF expression associated negatively with advanced cancer stage (Pglobal=0.05) and positively with smoking (Pglobal=0.14). After accounting for stage and other factors, neither HGF nor c-Met expression predicted survival. Using a cluster algorithm, two groups were identified: (Cluster 1: high expression of ER-alpha ER-beta, cytoplasmic PR, EGFR, and aromatase; Cluster 2: high expression of HGF, c-Met, and nuclear PR). Two lung cancer subgroups exhibiting dissimilar 7-protein IHC expression patterns were similar in terms of host and tumor characteristics and in terms of overall survival (log rank test: p=0.69).Among 22 htSNPs of ESR2 gene, we have identified that rare allele of rs1256061 is associated with the maximum ER-beta expression among patients with adenocarcinoma, but not with squamous cell carcinoma.The results of this research enhanced the knowledge of the role of HGF and c-Met on lung cancer survival and also suggested that the relationship between genetic variation of ESR2 gene and protein expression may differ by lung cancer histology. Understanding the roles, the expression patterns, and the genetic of steroid hormones, growth factors and their receptors in lung cancer is of great public health significance because it may enable biologically directed and individually tailored treatment and their possible use as biomarkers for early detection and prevention.
Variation in Recommendations for Modes of Delivery Post Ileal Pouch-Anal Anastomosis (IPAA) in Women with Ulcerative Colitis (2011)

Purpose: Fertility may be negatively affected in women with ulcerative colitis (UC) after ileal pouch-anal anastomosis (IPAA). However, it is unclear whether women who do conceive after IPAA should undergo vaginal delivery or cesarean section (CS). There are no formal consensus guidelines in this setting among gastroenterologists (GI), colorectal surgeons (CRS) and obstetricians (OB) who often co-manage these patients. This can lead to variation in care, a marker of poor quality. Furthermore, contrasting recommendations by different specialists may be confusing for the patient. Aim: To determine if there is variation among physicians in their recommendations for mode of delivery post-IPAA in a cohort of female UC patients. Methods: A total of 105 patients of child-bearing age at the time of IPAA (18-44 years old) performed by a single surgeon were surveyed via telephone and/or email using a survey instrument developed with input from GIs (n=2) and CRS (n=1) with expertise in IBD. Survey questions included patient demographics, IBD and surgical history, pregnancy history including any infertility work-up, recommendations regarding modes of delivery and delivery history. Results: A total of 44 (42%) patients (mean age; 38 years) specifically answered the survey question regarding mode of delivery recommended by their physicians (OB, High-risk OB, Midwife, GI, CRS). Half of these patients stated they did not discuss this with their physicians as they had no immediate plans (45%) or future plans (55%) for pregnancy post IPAA. Of the 22 seeking a recommendation, all 17 patients who asked their CRS were recommended to undergo CS. Twelve patients also asked a total of 16 OBs; 10 recommended vaginal delivery, 5 recommended CS, and 1 deferred recommendation until a later date. Four patients asked their GI doctor; 2 recommended CS and 2 were given no recommendation. One patient also asked a midwife, who recommended vaginal delivery. Seven had 13 full-term pregnancies; 6 women had a total of 9 CS, and 1 had a total of 4 vaginal deliveries. Of the 15 women who had not yet conceived, 5 were undergoing infertility work-up and 10 had electively deferred conception. However, at the time of a potential future pregnancy, 8 would elect for CS based on previous CRS recommendation, 1 would elect for vaginal delivery despite a CS recommendation and 6 were undecided. Conclusion: In our cohort, there was disconcordance between CRS and OB recommendations for mode of delivery post-IPAA. Patients tended to follow the recommendation of the CRS more than the OB. A study is underway to further examine variation in recommendations among different specialties managing women with IBD of childbearing age pre- and post-IPAA.
Tree search based configurable joint detection and decoding algorithms for MIMO systems (2016)

It has been shown that the Configurable Joint Detection-Decoding (CJDD) algorithms in MIMO systems can effectively reduce the complexity and improve the signal quality. Since the CJDD approach is based on the tree search algorithms and there exists various kinds of such methods with different characteristics, it is of great importance to explore the trade-offs between each algorithm and their impacts on different aspects of system performances. In this paper, we study the CJDD algorithm based on three types of tree search approaches: breadth-first search, depth-first search, and the Fano algorithm. We explicitly elucidate the advantages and disadvantages of each algorithm on the basis of timing complexity, area complexity, and run-time variability. Our goal is to shed more lights on the design and application of tree search type approaches on the MIMO wireless communication systems for different system design considerations.
Flexible Terahertz Metamaterials for Frequency Selective Surfaces (2013)

While recent years have seen great advances in the generation, detection, and application of terahertz frequency radiation, this region of the electromagnetic spectrum still suffers from a lack of efficient and effective frequency specific optical components. While such terahertz devices do exist, they are often limited by the materials they are based on and a lack of frequency selectivity and tunability. Metamaterial devices can provide frequency resonant behavior in the form of transmissive and reflective filters. Such a frequency selective surface can also be made tunable via the use of a flexible substrate. In this talk, we will highlight work involving the design, fabrication, and characterization of terahertz metamaterial devices based on flexible substrates. Finite element method simulations have been utilized to design a split-ring resonator (SRR) structure on a flexible SU8 polymer substrate with a targeted 250 GHz resonant response. Multiple configurations of SRR arrays have been fabricated on free standing SU8 substrates. These devices have subsequently been characterized using terahertz time-domain spectroscopy and imaging systems. The metamaterial devices have shown selective transmission and reflection over a narrow range of frequencies near the targeted resonance at 250 GHz. Details of both the design, fabrication, and characterization will be discussed.
Signs of aging‐related inflammation and adaptive reserves of aged mesenteric lymphatic vessels (2011)

Adequate adaptation of mesenteric lymphatic vessels (MLV) to various volumetric loads is vital for whole‐body fluid/macromolecule homeostasis, lipid adsorption, and immunity. Such adaptive reserves are greatly diminished in aged MLV due to severe alterations in their stretch‐ and shear‐induced contractile responses. We recently found signs of shear‐independent, NO‐dependent depletion of contractility in MLV isolated from adult (9 mo old) and aged (24 mo old) F‐344 rats. Subsequent experiments with high‐speed imaging of aged MLV in vivo provided additional evidence of significant aging‐induced contractile depression in this lymphatic network. Results of experiments with non‐selective nitric oxide synthase (NOS) inhibition by L‐NAME, performed both in and ex vivo, support the idea of constant activation of inducible NOS (iNOS) in aged MLV. These findings correlate with elevated immunohistochemical labeling of iNOS in aged MLV and with the biochemical signs of a chronic inflammatory environment in and around of aged lymphatic wall. Cumulatively, these findings demonstrate a link between age‐related inflammation and functional disturbances in aged MLV, which leads to their diminished ability to adapt effectively to normal and potential abnormal volumetric challenges in elderly. NIH RO1 AG030578, HL094269.
New Cathepsin Inhibitors to Explore the Fluorophilic Properties of the S2 Pocket of Cathepsin B: Design, Synthesis, and Biological Evaluation (2011)

Fluor-in or out? Based on β,β-difluorinated cycloaliphatic amino acids, a library of new dipeptide nitriles was evaluated as human cathepsin inhibitors. The orientation of the fluorinated face relative to the protein structure of cathepsin B was elucidated by molecular modeling and NMR studies (see figure). For (R)-configured eutomers, the fluorine atoms are directed to the S2 pocket, whereas in (S)-configured distomers, the fluorinated face is solvent-exposed. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
C-H Functionalization via C-H Activation and C-C Bond Formation with Arylsilanes (2007)

A novel methodology for performing the ortho arylation of acetanilides via C-H activation and cross-coupling with trialkoxyarylsilanes is introduced. Cu(OTf)2 is hereby used as oxidant and AgF as fluoride source activating the trialkoxy­silanes for cross-coupling.
Modularity and community structure in networks (2006)

Many networks of interest in the sciences, including social networks, computer networks, and metabolic and regulatory networks, are found to divide naturally into communities or modules. The problem of detecting and characterizing this community structure is one of the outstanding issues in the study of networked systems. One highly effective approach is the optimization of the quality function known as "modularity" over the possible divisions of a network. Here I show that the modularity can be expressed in terms of the eigenvectors of a characteristic matrix for the network, which I call the modularity matrix, and that this expression leads to a spectral algorithm for community detection that returns results of demonstrably higher quality than competing methods in shorter running times. I illustrate the method with applications to several published network data sets.
ON THE CORRECTNESS OF HARDWARE SCHEDULING MECHANISMS FOR OUT-OF-ORDER EXECUTION (1998)

Hardware scheduling mechanisms are commonly used in current processors in order to make better use of instruction level parallelism. So far, such a mechanism is considered to be correct, if it avoids the standard structural and data hazards. However, based on two classical scheduling mechanisms, it will be shown that this condition is neither sufficient nor necessary for the correctness of such a mechanism, and that deadlocks are a serious matter in out-of-order execution as well. In addition, the paper provides sufficient conditions for the correctness of scheduling mechanisms.
Nitroimidazoles Part 9. Synthesis, molecular docking, and anticancer evaluations of piperazine-tagged imidazole derivatives (2021)

Abstract New piperazine-tagged imidazole derivatives were synthesized via reaction of 1-alkyl/aryl-5-bromo-2-alkyl-4-nitro-1 H -imidazoles 1 – 3 with piperazine nucleophiles. Nine selected compounds were assessed for their antiproliferative inhibition potency against five human cancer cell lines (MCF-7, PC3, Du145, HepG2 and Dermal/Fibroblast). Compounds 7 and 10 are the most potent anticancer agents on HepG2 cell line with IC 50 values of (5.6 ± 0.5 µm) and (29.6 ± 7.6 µm) respectively, and on MCF-7 with IC 50 values of (32.1 ± 5.6 µm) and (46.2 ± 8.2 µm) respectively. The molecular docking of compounds 7 and 10 has been studied, and the results reveal that the newly designed piperazine-tagged imidazole derivatives bind to the hydrophobic pocket and polar contact with high affinity.
Stroke in Users of Low-Dose Oral Contraceptives (1996)

Stroke is rare among women of childbearing age. Low-estrogen oral-contraceptive preparations do not appear to increase the risk of stroke.
Synthesis of deuterated ent -beyeranes. Stereospecific reduction of a 4-axial aldehyde (1982)

Reduction of the 4a-axial aldehyde group in ent -3,19-dioxobeyer-15-en-17-oic acid (1) by sodium borohydride is shown to occur by attack on the Si -face of the carbonyl group. The synthesis of some ent -beyerane derivatives stereospecifically labelled with deuterium at C19 is described.
On-Chip Photovoltaic Energy Conversion in Bulk-CMOS for Indoor Applications (2014)

Modeling and design aspects of on-chip photovoltaic energy conversion, voltage boosting and storage in bulk CMOS are investigated under the constraints of indoor illumination and small form factor. A power-supply architecture consisting of a photovoltaic converter, a clock generator, a charge-pump and a storage capacitor is considered. Maximization of the recharging rate of the capacitor at the low end of irradiance is adopted as the aim of design optimization. First, photodiodes available for conversion in bulk CMOS are comparatively evaluated, and potentially the most efficient ones are experimentally characterized for the typical range of indoor irradiance. Next, a generic model is developed and experimentally verified for a clock generator powered by a converter built with these photodiodes. This is followed by the modeling and experimental verification of a Dickson charge-pump whose single-device rectifier is free of body effect and near-ideal in forward characteristic. These models are based on the subthreshold operation of devices as necessitated by optimization under the limitations of bulk-CMOS stacking and indoor irradiance. Guidelines for design optimization are derived from these models. Experimental work is based on two test chips fabricated in 0.18- μm bulk CMOS with deep n-well option.
Report on a European Community meeting on strategies for development and use of a future HIV vaccine (1990)

Ancelle-Park, Rosemary A.; Coutinho, Roel A.; Brunet, Jean-Baptiste; Piot, Peter; Goudsmit, Jaap; Koch, Meinrad A. Author Information
The efficiency of single institutional review board review in National Institute of Child Health and Human Development Cooperative Reproductive Medicine Network–initiated clinical trials (2018)

A single institutional review board reduced time for initial review and approval of protocols and informed consents, although time for the entire process was increased, as individual institutions retained oversight of components of required regulatory review. In order to best achieve the National Institute of Health's goals for improved efficiency in initiation and conduct of multisite clinical research, greater coordination with local institutional review boards is key to streamlining and accelerating initiation of multisite clinical research.
The Pathophysiology of Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) (2008)

Cardiac surgery associated acute kidney injury (CSA-AKI) is a significant clinical problem. Its pathogenesis is complex and multifactorial. It likely involved at least six major injury pathways: exogenous and endogenous toxins, metabolic factors, ischemia and reperfusion, neurohormonal activation, inflammation and oxidative stress. These mechanisms of injury are likely to be active at different times with different intensity and probably act synergistically. Because of such complexity and the small number of randomised controlled investigations in this field only limited recommendations can be made. Nonetheless, it appears important to avoid nephrotoxic drugs and desirable to avoid hyperglycemia in the peri-operative period. The duration of cardiopulmonary bypass should be limited whenever possible. Off-pump surgery, when indicated, may decrease the risk of AKI. Invasive hemodynamic monitoring focussed on attention to maintaining euvolemia, an adequate cardiac output and an adequate arterial blood pressure is desirable. Echocardiography may be useful in minimizing atheroembolic complications. The administration of N-acetylcysteine to protect the kidney from oxidative stress is not recommended. There is marked lack of randomised controlled trials in this field.