gebhart/patrepeval huggingface dataset:
Divergent effects of amygdala glucocorticoid and mineralocorticoid receptors in the regulation of visceral and somatic pain (2009)

Elevated amygdala activity and increased responsiveness of the hypothalamic-pituitary-adrenal axis have been observed in irritable bowel syndrome (IBS) patients. Recently, we demonstrated that corticosterone (Cort) placed on the amygdala induced anxiety-like behavior coupled with decreased thresholds for visceral and somatic pain in rats. Moreover, these studies suggested that the effects of Cort were dependent on both the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR); however, the specific contributions of these receptors to the interaction between corticosteroids and the amygdala are still unclear. In the present study, we sought to define the distinct roles of amygdaloid GR and MR in anxiety-like behavior, visceral sensitivity, and somatic sensitivity through selective pharmacological activation. Male Fischer 344 rats received bilateral implants on the dorsal margin of the central amygdala containing the GR agonist dexamethasone (Dex), the MR agonist aldosterone (Aldo), or cholesterol as a control. Our results showed that GR or MR activation significantly reduced open arm exploration on the elevated plus maze, a measure of anxiety-like behavior. Aldo increased the number of abdominal muscle contractions in response to all levels of colorectal distension (CRD). In contrast, Dex only increased visceral sensitivity at noxious levels of CRD. Furthermore, GR but not MR activation reduced somatic pain thresholds measured by the mechanical force required to elicit hindlimb withdrawal. In summary, GR and MR mediated-mechanisms induce anxiety and visceral hypersensitivity, whereas somatic sensitivity involves only GR, suggesting that corticosteroids may enhance visceral and somatic sensation via divergent processes originating in the amygdala and involving specific steroid receptor mechanisms.
Synthesis of titania with different shapes (2014)

Titania (TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) has been an important renewable material that is able to convert solar energy into chemical energy in recent years. Therefore, the main focus of this paper centers around different strategies and precursors to prepare TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> with various shapes, e.g. perforated hollow TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , anatase hollow TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> spheres, well-aligned TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and rambutan-like TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /liquid crystal composite, so as to utilize these materials in an environmental-benign way.
Imatinib accelerates progenitor cell‐mediated liver regeneration in choline‐deficient ethionine‐supplemented diet‐fed mice (2016)

Severe chronic hepatic injury can induce complex reparative processes. Ductular reaction and the appearance of small hepatocytes are standard components of this response, which is thought to have both adverse (e.g. fibrosis, carcinogenesis) and beneficial (regeneration) consequences. This complex tissue reaction is regulated by orchestrated cytokine action. We have investigated the influence of the tyrosine kinase inhibitor imatinib on a regenerative process. Ductular reaction was induced in mice by the widely used choline-deficient ethionine-supplemented diet (CDE). Test animals were treated daily with imatinib. After 6 weeks of treatment, imatinib successfully reduced the extent of ductular reaction and fibrosis in the CDE model. Furthermore, the number of small hepatocytes increased, and these cells had high proliferative activity, were positive for hepatocyte nuclear factor 4 and expressed high levels of albumin and peroxisome proliferator-activated receptor alpha. The overall functional zonality of the hepatic parenchyma (cytochrome P450 2E1 and glucose 6 phosphatase activity; endogenous biotin content) was maintained. The expression of platelet-derived growth factor receptor beta, which is the major target of imatinib, was downregulated. The anti-fibrotic activity of imatinib has already been reported in several experimental models. Additionally, in the CDE model imatinib was able to enhance regeneration and preserve the functional arrangement of hepatic lobules. These results suggest that imatinib might promote the recovery of the liver following parenchymal injury through the inhibition of platelet-derived growth factor receptor beta.
Clustering and Recommendation for Semantic Web Service in Time Series (2014)

Promoted by cloud technology and new websites, plenty and variety of Web services are emerging in the Internet. Meanwhile some Web services become outdated even obsolete due to new versions, and a normal phenomenon is that some services work well only with other services of older versions. These laggard or improper services are lowering the performance of the composite service they involved in. In addition, using current technology to identify proper semantic services for a composite service is time-consuming and inaccurate. Thus, we proposed a clustering method and a recommendation method to deal with these problems. Clustering technology is used to classify semantic services according to their topics, functionality and other aspects from plenty of services. Recommendation technology is used to predict the possible preference of a composite service, and recommend possible component services to the composite service according to the history information of invocations and similar composite services. The experiments show that our clustering method with the help of Ontology and TF/IDF technology is more accurate than others, and our recommendation method has less average error than others in the series of missing rate.
An Interspecific Backcross of Lycopersicon esculentum × L. hirsutum: Linkage Analysis and a QTL Study of Sexual Compatibility Factors and Floral Traits (1997)

A BC1 population of the self-compatible tomato Lycopersicon esculentum and its wild self-incompatible relative L. hirsutum f. typicum was used for restriction fragment length polymorphism linkage analysis and quantitative trait loci (QTL) mapping of reproductive behavior and floral traits. The self-incompatibility locus, S, on chromosome 1 harbored the only QTL for self-incompatibility indicating that the transition to self-compatibility in the lineage leading to the cultivated tomato was primarily the result of mutations at the S locus. Moreover, the major QTL controlling unilateral incongruity also mapped to the S locus, supporting the hypothesis that self-incompatibility and unilateral incongruity are not independent mechanisms. The mating behavior of near-isogenic lines carrying the L. hirsutum allele for the S locus on chromosome 1 in an otherwise L. esculentum background support these conclusions. The S locus region of chromosome 1 also harbors most major QTL for several floral traits important to pollination biology (e.g., number and size of flowers), suggesting a gene complex controlling both genetic and morphological mechanisms of reproduction control. Similar associations in other flowering plants suggest that such complex may have been conserved since early periods of plant evolution or else reflect a convergent evolutionary process.
Nanoporous metal formates for krypton/xenon separation (2013)

Metal(II) formates (Co and Ni) show a significantly larger heat of adsorption for xenon than krypton across all loadings due to size selectivity in the primary adsorption site.
I‐Dopa in the treatment of parkinsonism (1970)

Clinical experience over the last decade indicates that 1‐3,4‐dihydroxyphenylalanine ( l ‐dopa, levo dopa) may replace other forms of medical and surgical treatment in a substantial proportion of parkinsonian patients. This therapeutic development has arisen from the application of new concepts derived from a wide range of neuro‐pharmacological investigations. In this review the subject will be considered in the following stages: pharmacological background; therapeutic effects; adverse reactions; pharmacokinetics; other drugs modifying dopaminergic function.
A Study on Textless Back Translation of China Boy From Acculturation Perspective (2018)

Textless back translation refers to the kind of back translation in which the translator retranslates China-themed works written in English language back into the Chinese language. Based on English-Chinese bilingual corpus and acculturation theory, this paper attempts to probe into language features and translation strategies of the textless back translation of American Chinese writer Gus Lee’s novel China Boy . The paper holds that, compared with the original work, the diction of the textless back translation is not richer and less diverse; that the syntactical structure is briefer, making it easier to understand; that the translators attach great importance to the reproduction of the theme of the original while exerting their subjectivity at the textual level; and that the contents, foreword and preface, notes and interview with the author are inserted as its paratexts so as to help the target readers better understand the translators’ thoughts and subjectivity. As to translation strategies, the textless back translation as such, guided by integration and assimilation strategies, tends to adopt domestication in order to restore host cultural elements, which is of significance to the cultural feedback; the translation of this kind, guided by separation strategy, is inclined to employ foreignization in order to emphasize the preservation of guest cultural elements but weaken the reproduction of host cultural elements; the translation, guided by marginalization strategy usually gives rise to mistranslations, in which translators usually need to refer to domestication as so to correctly convey their connotations.
Voice extraction by on-line signal separation and recovery (1999)

The paper presents a formulation and an implementation of a system for voice output extraction (VOX) in real-time and near-real-time realistic real-world applications. A key component includes voice-signal separation and recovery from a mixture in practical environments. The signal separation and extraction component includes several algorithmic modules with a variety of sophistication levels, which include dynamic processing neural networks in tandem with (dynamic) adaptive methods. These adaptive methods make use of optimization theory subject to the dynamic network constraints to enable practical algorithms. The underlying technology platforms used in the compiled VOX software can significantly facilitate the embedding of speech recognition into many environments. Two demonstrations are described: one is PC-based and is near-real-time, the second is digital signal processing based and is real time. Sample results are described to quantify the performance of the overall systems.
Generic framework for high-dimensional fixed-effects ANOVA (2011)

In functional genomics it is more rule than exception that experimental designs are used to generate the data. The samples of the resulting data sets are thus organized according to this design and for each sample many biochemical compounds are measured, e.g. typically thousands of gene-expressions or hundreds of metabolites. This results in high-dimensional data sets with an underlying experimental design. Several methods have recently become available for analyzing such data while utilizing the underlying design. We review these methods by putting them in a unifying and general framework to facilitate understanding the (dis-)similarities between the methods. The biological question dictates which method to use and the framework allows for building new methods to accommodate a range of such biological questions. The framework is built on well known fixed-effect ANOVA models and subsequent dimension reduction. We present the framework both in matrix algebra as well as in more insightful geometrical terms. We show the workings of the different special cases of our framework with a real-life metabolomics example from nutritional research and a gene-expression example from the field of virology.
Plant behaviour dictation using a sliding mode model reference controller (2006)

In this work, a sliding mode approach to model reference control of fully actuated electromechanical systems affine with control is presented. Instead of the traditional state error regulator between the desired model and the actual plant, the proposed approach utilizes the fact that on sliding mode, plant is enforced to remain on the sliding manifold. Performance of the controller is demonstrated on simulations and experiments on a piezoactuator. Results show that the approach is effective in dictating the nonlinear plant to behave as the desired linear model, so as to drive the piezoactuator for 1 nm step with only an open loop position controller in addition to the sliding mode model reference controller proposed
Supplementary Table 2 from The Humoral Immune System Has a Key Prognostic Impact in Node-Negative Breast Cancer (2023)

Supplementary Table 2 from The Humoral Immune System Has a Key Prognostic Impact in Node-Negative Breast Cancer
Crystal Growth and Characterization of II-VI Compound Light Emitting Diodes with Novel Superlattice Quasi-Quaternary Cladding Layers on InP Substrates (1998)

1998 International Conference on Solid State Devices and Materials,Crystal Growth and Characterization of II-VI Compound Light Emitting Diodes with Novel Superlattice Quasi-Quaternary Cladding Layers on InP Substrates
Performance Evaluation of Complex Product Development (2009)

In this paper a conceptual performance evaluation framework is proposed and discussed. The aim of the framework is to present a tool to stakeholders, involved in dynamic complex product development ...
A multiparametric study of gold nanoparticles cytotoxicity, internalization and permeability using anin vitromodel of blood–brain barrier. Influence of size, shape and capping agent (2019)

Gold nanoparticles (AuNPs) have biomedical application on imaging and due to increased optical performance, star-shaped AuNPs are of special interest. Because shape, size and capping greatly influence their toxicokinetics and toxicodynamics, a systematic multiparametric comparative study of the influence of these parameters on the cytotoxicity, internalization, and in vitro permeability was conducted in human Cerebral Microvascular Endothelial Cell line (hCMEC/D3), an <i>in vitro</i> model of the human blood-brain barrier (BBB). AuNPs of different size (14 nm and ∼50 nm), shape (spheres and stars), and coating (11-mercaptoundecanoic acid or MUA and sodium citrate) were synthesized and fully characterized. The time- and concentration-dependent cytotoxic profile of the tested AuNPs differed for the different AuNPs. Generally, toxicity was greater for stars relative to sphere-shaped AuNPs, and citrate coating was more toxic than MUA. Regarding the influence of size, smaller-sized AuNPs were more cytotoxic when compared at the same Au concentration. However, when the concentration of AuNPs was expressed as the number of AuNPs/mL, a higher degree of cytotoxicity was noted for the larger ̴50 nm AuNPs. To understand the influence of size, shape and capping, a systematic study design, in which only one of the variables changes, is determinant for correct data interpretation. Considering the results herein presented, for the sake of comparison of differently-sized AuNPs, it is preferable to design the study based upon the number of nanoparticles, since at a fixed Au concentration the number of particles available to promote effect is higher for smaller-sized AuNPs. Cellular internalization also differed among the tested AuNPs; although all were unable to cross the in vitro BBB, the intracellularly accumulated AuNPs can induce cell damage and later compromise BBB integrity and permeability.
FIM Regularity for Gaussian Semi-Blind MIMO FIR Channel Estimation (2006)

We consider the problem of semi-blind (SB) channel estimation for multiple-input multiple-output (MIMO) finite impulse response (FIR) channels. We motivate a Fisher information matrix (FIM) based analysis of the semi-blind estimation problem and demonstrate that the semi-blind FIM can be written as the sum of a blind FlM J <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">B</sup> and training symbol FTM J <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sup> . We show that the blind FIM J <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">B</sup> is rank deficient and establish the minimum number of training symbols necessary to achieve regularity (full-rank) of the FIM for identifiability. We also illustrate that an SB scheme can potentially be very efficient compared to an exclusively training based scheme since it estimates very few un-constrained parameters. It is then demonstrated that the rank deficiency of the FIM for an irreducible MIMO FIR channel arises because of a unitary (rotation) matrix indeterminacy. Based on this analysis a semi-blind algorithm is proposed for MIMO FIR channel estimation
Multimedia Workstations: Electronic Assistants for HealthCare Professionals (1996)

The increasing costs of health care and the economic reality has produced an interesting paradox for the health professional to perform more clinical work with fewer support personnel. Moreover, an explosion of the knowledge-base that underlies sound clinical care not only makes effective time management critical, but also knowledge management compelling. A multimedia workstation is an electronic assistant for the busy health professional that can help with administrative tasks and give access to clinical information and knowledge networks. The multimedia nature of processed information reflects an evolution of medical technologies that involve more and more complex objects such as video sequences or digitized signals. Analysis of the 445 Medline-indexed publications for the January 1991 to December 1994 period, that included the word "workstation" either in their title or in their abstract, helps in refining objectives and challenges both for health professionals and decision makers. From an engineering perspective, development of a workstation requires the integration into the same environments of tools to localize, access, manipulate and communicate the required information. The long-term goal is to establish an easy access in a collaborative working environment that gives the end-user the feeling of a single virtual health enterprise, driven by an integrated computer system when the information system relies on a set of heterogeneous and geographically distributed components. Consequences in terms of migration from traditional client/server architectures to more client/network architectures are considered.
Nasal Mast Cell Response to Natural Allergen Exposure (1989)

A redistribution of mast cells into the epithelium and towards the mucosal surface was previously observed during the allergy season in individuals allergic to birch pollen. We have therefore attempted to investigate in greater detail the role of mast cells in mucosal allergy by the study of the morphological and biochemical changes that occur in the nasal mucosa of allergic individuals during natural allergen exposure. An activation of the intraepithelial mast cells was indicated by the observation of ultrastructural signs of a secretory activity. We also found that the normal strong correlation between mast cell numbers and histamine content in the nasal mucosa was absent in specimens taken during allergen exposure, which was interpreted as a result of a release of histamine from the mast cells with the appearance of a transient, non-mast cell pool of tissue histamine. Furthermore, the histamine content of the nasal mucosa during the pollen season was strongly correlated to the severity of symptoms experienced by the patients. These observations provide additional evidence that mucosal mast cells have a pathogenetic role in continuous allergic airway disease.
The gut microbiota-related metabolite phenylacetylglutamine associates with increased risk of incident coronary artery disease (2020)

The levels of 33 plasma metabolites were correlated with the gut microbiota. Out of these, PAG was associated with an increased risk of future CAD independently of other cardiovascular risk factors. Our results highlight a link between the gut microbiota and CAD risk and should encourage further studies testing if modification of PAG levels inhibits development of CAD.
Disinfective Effect of the Ultra Sonic Ozone Washer. (1997)

The disinfecting effects of an ultra sonic ozone washer were evaluated in antiseptic-resistant strains of methicillin-resistant Staphylococcus aureus (MRSA). Two antiseptic-sensitive strains and two antiseptic-resistant strains were killed after treatment with the washer. (The leakage of the ozone gas from the washer was not detected.) The resin-plates to which gingival bacteria, Candida albicans and gingivalis bacteria, Streptococcus sanguis, adhered, were used as a model for the washing of an artificial tooth. The numbers of these bacteria detected before the washing, were both 107 cfu/ml while those detected in washing water before washing with ozonized water were respectively none and 104 cfu/ml. Only 10-20 colonies were grown on the resin-plates of both bacteria. A resin-plate adhering Helicobacter pylori, which is presumed to be associated with active chronic gastritis and duodenal ulcer diseases, was also tested. Bacteria of 108 cfu/ml before the washing was not detected in washing water after washing with ozonized water. Only 10-20 colonies were grown on the resin-plate. These results clearly confirmed that the ultra sonic ozone washer are a useful means for disinfecting instruments and devices contaminated with antisepticresistant strains of MRSA and an artificial tooth.
[Endorphins 1989: neuroendocrine aspects]. (1989)

Endorphins represent a family of brain peptides having an opioid core structure responsible for their morphinomimetic activity. We present an overview of the biology of endorphins including their origin, neuroanatomical distribution, regulatory mechanisms and interaction with opioid receptors taking neuronal cellular function in situ as our focal point of interest. Differential biochemical processing and regulatory mechanisms both at the pre- and post-translational level in the various brain areas contribute to the biochemical and functional diversity of peptides generated from common precursors in keeping with the selective needs and functions of neuronal circuits. Physiological significance requires interaction of the various endogenous ligands thus generated with appropriate receptors, sometimes located well beyond the distance of a synaptic cleft as demonstrated by the diverging ligand/receptors neurochemical topographical maps. Physiological analysis reveals a multitude of potential interactions between peptides and classical neurotransmitters in part as a result of their common subcellular location within individual synaptic vesicles but also in relation to qualitatively different post-synaptic effects and metabolism, enhancing the complexity of their potential role in neuronal function. Endorphins may contribute to major neuroendocrine systems such as analgesia, endocrine and autonomic function, mental function and behavior. Their implication in various neuropsychiatric and endocrine clinical disorders will be briefly reviewed.