gebhart/patrepeval huggingface dataset:
P1940Reciprocal regulation of Endothelial-Mesenchymal Transition by MAPK7 and EZH2 activity in Intimal Hyperplasia and Coronary Artery Disease (2019)

Abstract Introduction Endothelial cells play a pivotal role in the formation of neointimal lesions by the acquisition of a fibro-proliferative phenotype through endothelial-to-mesenchymal transition (EndMT). Uniform laminar shear stress activates the mitogen-activated protein kinase 7 (MAPK7) which suppresses EndMT. It is elusive how MAPK7 activity is regulated in fibroproliferative disease. We recently found in intimal hyperplasia the signaling activity of MAPK7 is rapidly lost through the activation microRNA-374b. The histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2), which is the catalytic subunit of the Polycomb Repressive Complex 2, plays a pivotal role in endothelial dysfunction. EZH2 trimethylates lysine 27 on histone 3, which silences gene expression and is elevated in endothelial cells in atherosclerotic lesions. Here, we found the reciprocity that exists between MAPK7 and EZH2 in the regulation of EndMT and in human coronary artery stenosis. Materials and results In endothelial cells, activation of MAPK7 increases the expression of microRNA-101, which represses the expression of EZH2. Reciprocally, the loss of EZH2 coincides with a decreased expression of the Dual Specificity Phosphatase (DUSP)-1 and DUSP-6 – the phosphatases responsible for the dephosphorylation of MAPK7 - which facilitates the activation of MAPK7. H3K27Me3, the repressive histone mark placed by EZH2, is abundantly present in the promoter regions of the miR-200b/a/429 and miR-200c/141 gene clusters, which are responsible for the loss of DUSP-1 and DUSP-6 expression. Endothelial cells deficient in EZH2 have reduced levels of H3K27Me3 at these gene promoters, which associates with the increased expression of miR-200b and miR-200c and concurrent increased MAPK7 activation. In endothelial cells with constitutively active MAPK7 signaling (MEK5D), the enrichment of H3K27Me3 at the promoter regions of miR-200b/a/429 (1.6-fold, p=0.034) and miR-200c/141 (1.9-fold, p=0.035) is decreased, suggesting that MAPK7 activation results in a decreased EZH2 activity. Disbalances in this reciprocal signaling circuit culminate in the induction of EndMT and associate to the severity of human coronary artery stenosis. Conclusion In summary, we show that in endothelial cells there is reciprocity between MAPK7 signaling and EZH2 expression and that disturbances in this reciprocal signaling circuit associate with the induction of EndMT and severity of human coronary artery stenosis. The reciprocity between MAPK7 and EZH2 is governed by a complex mechanism involving microRNAs and the phosphatases DUSP-1 and DUSP-6. Our study contributes to a better understanding of the molecular and epigenetic cascades that underlie EndMT during coronary artery stenosis and might identify novel targets for therapy. Acknowledgement/Funding Mongolian Government Scholarship #621
A Novel Thermally Latent Anionic Initiator. Polymerization of Epoxide with Hydroxylamide Based on Thermal Dissociation (2003)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTA Novel Thermally Latent Anionic Initiator. Polymerization of Epoxide with Hydroxylamide Based on Thermal DissociationFumio Sanda, Tomoyoshi Kaizuka, Atsushi Sudo, and Takeshi EndoView Author Information Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 606-8501, Japan; Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan; Molecular Engineering Institute, Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka 820-8555, Japan; and Department of Polymer Science and Engineering, Faculty of Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan Cite this: Macromolecules 2003, 36, 4, 967–968Publication Date (Web):January 28, 2003Publication History Received10 October 2002Published online28 January 2003Published inissue 1 February 2003https://pubs.acs.org/doi/10.1021/ma0257292https://doi.org/10.1021/ma0257292rapid-communicationACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views554Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Amides,Dissociation,Nuclear magnetic resonance spectroscopy,Organic compounds,Polymerization Get e-Alerts
How IvIg Can Mitigate Covid-19 Disease: A Symmetrical Immune Network Model (2021)

In this report we provide a hypothesis of how intravenous immunoglobulin (IvIg) (pooled therapeutic normal IgG) mitigates the severe disease after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. The disease is caused by an overreaction of the innate immune system producing a cytokine storm and inflicting multiple organ damage. Our interpretation of IvIg therapy hinges on a recent analysis of the immune dysregulation in Covid-19 infection. Previous infections with common cold coronavirus induce suppressor memory B cells that inhibit an immune response to Covid-19. The repertoire of natural antibodies (IvIg) contains suppressing antibodies in a symmetrically balanced network structure. When this repertoire interacts with the imbalanced network in the infected patient, it can neutralize the suppression of an antibody response against Covid-19. The described scenario for IvIg in Covid-19 infection may also apply in the therapy of autoimmune diseases.
Type-I to type-II superlattice transition in strained layers ofInxGa1−xAs grown on InP (1988)

Optical and electronic properties of ${\mathrm{In}}_{\mathrm{x}}$${\mathrm{Ga}}_{1\mathrm{\ensuremath{-}}\mathrm{x}}$As strained-layer superlattices grown on InP have been investigated over the entire range of indium compositions, 0&lt;x&lt;1. We demonstrate a type-I to type-II superlattice transition at x\ensuremath{\lesssim}0.20. Below this critical concentration electrons become confined to the InP layer. Excellent agreement is obtained with a band-structure calculation based on empirical relative valence-band energies and deformation-potential theory. This agreement suggessts that the effect of strain on these relative energies can be neglected.
Le castrum Thigernum retrouvé ? Nouvelles recherches sur les origines de Thiers (Puy-de-Dôme) (2022)

1. Introduction Les origines de la ville de Thiers sont essentiellement connues grâce à la mention d’un Thigernum castrum par Grégoire de Tours. Dans le dernier tiers du vie siècle, il s’agit a priori d’une agglomération partagée en deux « quartiers », correspondant respectivement au castrum assiégé par le roi Thierry autour de 530, où se situe un lieu de culte abritant les reliques de saint Symphorien, et au secteur où prend place une église dédiée à saint Genès, consacrée par l’évêque de Cl...
Low Crosstalk Structure Design and Performance Simulation in 19-core Tellurite Glass Amplification Fiber (2023)

åºäºç©ºåå¤ç¨ææ¯çå¤è¯å çº¤éä¿¡æ ¸å¿ææ ä¹ä¸æ¯ä¿¡éä¸²æ°ï¼è¯¥é®é¢çå­å¨æå¤§å°å½±åçä¼ è¾è·ç¦»åä¿¡å·è´¨éï¼å°¤å ¶æ¯å¨å®½å¸¦å çº¤æ¾å¤§ç³»ç»ä¸­ãæ¬æéç¹è®¨è®ºäºå¼±è¦å19è¯å çº¤çä¸²æ°é®é¢ï¼åæ¶æåºäºä¸ç§å©äºå¤ç»åç¢²é ¸çç»çæ¤åå¶å¤çæ²æ§½è¾ å©å19è¯å çº¤ï¼å¹¶éç¨è¦ååççè®ºåæéå æ³å¯¹æ¨¡åè¿è¡äºç¸å ³æ§è½çæ°å¼ä»¿çï¼ç³»ç»ç ç©¶äºæ²æ§½å°ºå¯¸ãæå°çåå¸åç¸å ³å çº¤åæ°å¯¹è¯é´ä¸²æ°çå½±åãä»¿çç»æè¡¨æï¼ä¼åè®¾è®¡åçå çº¤å¨1 550 nmå¤æ¥æ-156 dB/100 mçä½ä¸²æ°å¼ï¼å¯ä»¥æ»¡è¶³å¤§å®¹éå çº¤éä¿¡ç¨å®½å¸¦å æ¾å¤§å¨çåºç¨éæ±ã
CRISPR/Cas9n-Mediated Deletion of the Snail 1Gene (SNAI1) Reveals Its Role in Regulating Cell Morphology, Cell-Cell Interactions, and Gene Expression in Ovarian Cancer (RMG-1) Cells (2015)

Snail1 is a transcription factor that induces the epithelial to mesenchymal transition (EMT). During EMT, epithelial cells lose their junctions, reorganize their cytoskeletons, and reprogram gene expression. Although Snail1 is a prominent repressor of E-cadherin transcription, its precise roles in each of the phenomena of EMT are not completely understood, particularly in cytoskeletal changes. Previous studies have employed gene knockdown systems to determine the functions of Snail1. However, incomplete protein knockdown is often associated with these systems, which may cause incorrect interpretation of the data. To more precisely evaluate the functions of Snail1, we generated a stable cell line with a targeted ablation of Snail1 (Snail1 KO) by using the CRISPR/Cas9n system. Snail1 KO cells show increased cell-cell adhesion, decreased cell-substrate adhesion and cell migration, changes to their cytoskeletal organization that include few stress fibers and abundant cortical actin, and upregulation of epithelial marker genes such as E-cadherin, occludin, and claudin-1. However, morphological changes were induced by treatment of Snail1 KO cells with TGF-beta. Other transcription factors that induce EMT were also induced by treatment with TGF-beta. The precise deletion of Snail1 by the CRISPR/Cas9n system provides clear evidence that loss of Snail1 causes changes in the actin cytoskeleton, decreases cell-substrate adhesion, and increases cell-cell adhesion. Treatment of RMG1 cells with TGF-beta suggests redundancy among the transcription factors that induce EMT.
Recombinant Erythropoietin for the Treatment of Anemia in Inflammatory Bowel Disease (1996)

In patients with inflammatory bowel disease and anemia refractory to treatment with iron and vitamins, treatment with oral iron and recombinant erythropoietin can raise hemoglobin levels.
A fast method for detecting and estimating motion in radar images using normalized cross-correlation (2018)

Motion detection and estimation is an important task in several applications of image analysis, including scenarios such as satellite cross-cueing or detecting small shifts in terrain. One widely employed technique for estimating the amount of motion between two images is Normalized Cross-Correlation (NCC), although its computational cost is often prohibitively high for time-sensitive applications. In this work, a previously developed algorithm that uses sum tables to calculate the NCC efficiently for 1-D ultrasound traces is adapted to work for 2-D radar images. The performance of the sum tables algorithm is quantified both theoretically as well as with Synthetic Aperture Radar (SAR) data from the RADARSAT-2 satellite, and is shown to provide time savings of 97% or more compared to the direct method. The algorithm described herein could be used to provide more timely intelligence in situations where it is desirable to detect and estimate the motion of targets using remote sensing.
Performance comparison of NRZ and RZ modulations with and without forward error corrections for free-space optical communication (2005)

Our free-space optical (FSO) communication experiments show that, compared to non-return-to-zero (NRZ) encoding, return-to-zero (RZ) data format is more robust to atmospheric turbulence. A forward error correction coding gain up to 5 dB is obtained at a bit error-rate of 1x10<sup>-15</sup> for FSO link with Reed-Solomon (255,239) generic FEC (GFEC) which is specified in ITU-T G.709 standards. The coding gain increases further up to 1.6 dB with enhanced FEC (EFEC) that adds no additional overheads. Still, the link-margin with both GFEC and EFEC decreases with atmospheric turbulence.
Characterization of the Escherichia coli σS core regulon by Chromatin Immunoprecipitation-sequencing (ChIP-seq) analysis (2015)

In bacteria, selective promoter recognition by RNA polymerase is achieved by its association with σ factors, accessory subunits able to direct RNA polymerase "core enzyme" (E) to different promoter sequences. Using Chromatin Immunoprecipitation-sequencing (ChIP-seq), we searched for promoters bound by the σ(S)-associated RNA polymerase form (Eσ(S)) during transition from exponential to stationary phase. We identified 63 binding sites for Eσ(S) overlapping known or putative promoters, often located upstream of genes (encoding either ORFs or non-coding RNAs) showing at least some degree of dependence on the σ(S)-encoding rpoS gene. Eσ(S) binding did not always correlate with an increase in transcription level, suggesting that, at some σ(S)-dependent promoters, Eσ(S) might remain poised in a pre-initiation state upon binding. A large fraction of Eσ(S)-binding sites corresponded to promoters recognized by RNA polymerase associated with σ(70) or other σ factors, suggesting a considerable overlap in promoter recognition between different forms of RNA polymerase. In particular, Eσ(S) appears to contribute significantly to transcription of genes encoding proteins involved in LPS biosynthesis and in cell surface composition. Finally, our results highlight a direct role of Eσ(S) in the regulation of non coding RNAs, such as OmrA/B, RyeA/B and SibC.
ROTATIONALLY MOLDED LIQUID CRYSTALLINE POLYMERS (2003)

Rotational molding is a unique process for producing hollow plastic parts. Rotational molding offers advantages of low cost tooling and can produce very large parts with complicated shapes. Products made by rotational molding include water tanks with capacities up to 20,000 gallons, truck bed liners, playground equipment, air ducts, Nylon fuel tanks, pipes, toys, stretchers, kayaks, pallets, and many others. Thermotropic liquid crystalline polymers are an important class of engineering resins employed in a wide variety of applications. Thermotropic liquid crystalline polymers resins are composed of semi-rigid, nearly linear polymeric chains resulting in an ordered mesomorphic phase between the crystalline solid and the isotropic liquid. Ordering of the rigid rod-like polymers in the melt phase yields microfibrous, self-reinforcing polymer structures with outstanding mechanical and thermal properties. Rotational molding of liquid crystalline polymer resins results in high strength and high temperature hollow structures useful in a variety of applications. Various fillers and reinforcements can potentially be added to improve properties of the hollow structures. This paper focuses on the process and properties of rotationally molded liquid crystalline polymers.
Optical Microscopy as a Tool for Studying Sex Differences in Pain and Analgesia (2020)

The sensation of pain is one that is experienced by virtually every human being. However, the same stimulus can evoke experiences that vary wildly from individual to individual, and from occasion to occasion. Some of these differences appear to be related to sex. However, the mechanisms that underlie these differences remain unclear. We have examined several different aspects of these differences using a combination of behavioral, biochemical, and light microscopic methods.
Excess electron transfer in flavin-capped, thymine dimer-containing DNA hairpins (2003)

The transfer of an excess electron through DNA was investigated with DNA hairpins, which contain a flavin cap functioning as an electron donor. A thymine dimer with an open backbone acts as the electron acceptor. The dimer translates the electron capture into a strand break, which is readily detectable by HPLC. Analysis of four hairpins, in which the distance between the flavin donor and the dimer acceptor was systematically increased, revealed a flat distance dependence of the repair efficiency supporting the view that excess electrons hop through DNA using intermediate A-T base pairs as temporary charge carriers.
Safety and efficacy of sofosbuvir/velpatasvir/voxilaprevir in post-liver transplant patients with previous direct-acting antiviral failure: Six case reports (2020)

This case series demonstrate the real-world efficacy and safety of SOF/VEL/VOX in the post liver transplant setting. Treatment was successful with all patients achieving SVR, it was well tolerated, and there were minimal drug-drug interactions with their immunosuppressants.
Augmenting Mobile Phone Interaction with Face-Engaged Gestures (2016)

The movement of a user's face, easily detected by a smartphone's front camera, is an underexploited input modality for mobile interactions. We introduce three sets of face-engaged interaction techniques for augmenting the traditional mobile inputs, which leverages the combination of the head movements with touch gestures and device motions, all sensed via the phone's built-in sensors. We systematically present the space of design considerations for mobile interactions using one or more of the three input modalities (i.e., touch, motion, and head). The additional affordances of the proposed techniques expand the mobile interaction vocabulary, and can facilitate unique usage scenarios such as one-hand or touch-free interaction. An initial evaluation was conducted and users had positive reactions to the new techniques, indicating the promise of an intuitive and convenient user experience.
Forecasting PV Panel Output Using Prophet Time Series Machine Learning Model (2020)

Due to climate change effects, the demand for renewable energy is growing immensely around the world. Photovoltaic (PV) panels are widely popular as a vital source of renewable energy all over the world as well as in Bangladesh. However, besides solar irradiance, the panel output is greatly affected by some of the weather parameters like temperature, humidity, wind, etc. Reliable forecasting of PV panel output is essential for capacity planning in advance to efficiently manage the energy distribution. This paper presents a method to forecast the PV panel output energy using a machine learning model, known as the Prophet Model used for a univariate time series forecasting. For this study, the PV panel generated data are collected from an outdoor experimental set-up throughout the full winter season in Bangladesh. Based on the data, forecasting of one-day-ahead PV panel short circuit current is done, and then the estimation of PV panel output energy is made. The results show the proposed forecasting method to be quite encouraging and reliable one while providing a higher coefficient of determination value with an average 0.9772 for one-day-ahead PV panel output energy forecasting.
600 MHz1H and13C NMR Full Assignments of Two Saponins fromNothapodytes foetida (1996)

The application of one- and two-dimensional nuclear magnetic resonance techniques to the structure elucidation of two saponins from Nothapodytes foetida is reported. Detailed structural information about the sapogenin, protobassic acid, and the oligosaccharidic chains, including sugar sequence and position of glycosidation, is provided.
Recombinant factor VIIa for hemorrhagic stroke treatment at earliest possible time (FASTEST): Protocol for a phase III, double-blind, randomized, placebo-controlled trial (2021)

In the US, FASTEST will be first NIH StrokeNet Trial with an Exception from Informed Consent which allows enrollment of non-communicative patients without an immediately identifiable proxy.
NF-κB Hyperactivation in Tumor Tissues Allows Tumor-Selective Reprogramming of the Chemokine Microenvironment to Enhance the Recruitment of Cytolytic T Effector Cells (2012)

Tumor infiltration with effector CD8(+) T cells (T(eff)) predicts longer recurrence-free survival in many types of human cancer, illustrating the broad significance of T(eff) for effective immunosurveillance. Colorectal tumors with reduced accumulation of T(eff) express low levels of T(eff)-attracting chemokines such as CXCL10/IP10 and CCL5/RANTES. In this study, we investigated the feasibility of enhancing tumor production of T(eff)-attracting chemokines as a cancer therapeutic strategy using a tissue explant culture system to analyze chemokine induction in intact tumor tissues. In different tumor explants, we observed highly heterogeneous responses to IFNα or poly-I:C (a TLR3 ligand) when they were applied individually. In contrast, a combination of IFNα and poly-I:C uniformly enhanced the production of CXCL10 and CCL5 in all tumor lesions. Moreover, these effects could be optimized by the further addition of COX inhibitors. Applying this triple combination also uniformly suppressed the production of CCL22/MDC, a chemokine associated with infiltration of T regulatory cells (T(reg)). The T(eff)-enhancing effects of this treatment occurred selectively in tumor tissues, as compared with tissues derived from tumor margins. These effects relied on the increased propensity of tumor-associated cells (mostly fibroblasts and infiltrating inflammatory cells) to hyperactivate NF-κB and produce T(eff)-attracting chemokines in response to treatment, resulting in an enhanced ability of the treated tumors to attract T(eff) cells and reduced ability to attract T(reg) cells. Together, our findings suggest the feasibility of exploiting NF-κB hyperactivation in the tumor microenvironment to selectively enhance T(eff) entry into colon tumors.
Recent results from pixelated TlBr detectors with Tl electrodes operated at room-temperature (2016)

Thallium-bromide (TlBr) is a viable alternative to CZT for room-temperature gamma ray spectroscopy because of its high atomic number, high density, and wide band-gap. Sub-1% FWHM energy resolution at 662 keV has been achieved on 5 mm thick pixelated devices, however, these results are mostly limited to stable operation at -20°C. During room-temperature operation, the devices degrade and fail, a phenomenon known as polarization. Polarization is likely caused by bulk-to-contact interactions facilitated by ionic conduction. In 2008, Hitomi et al. found that room-temperature lifetime could be extended by applying Tl electrodes. In this work we verify stable room-temperature performance of a 4.1 mm thick pixelated TlBr detector with Tl electrodes. Energy resolution, mobility-lifetime product, and resistivity are characterized and presented. Resolutions of 1.6% and 1.2% FWHM are achieved for all depths and cathode-side events only, respectively. A very high electron mobility-lifetime product is calculated: 3.1±0.2 ·10-2 cm2/V.
Writing and erasing efficiency analysis on optical-storage media using scanning surface potential microscopy (2006)

The authors demonstrate a rapid and convenient method for the determination of writing and erasing laser powers in phase-change media based on scanning surface potential microscopy using a conductive tip. Commercially available digital versatile disks that are rewritable with initialization process are measured in experiments. The results of measurement show that when the disk is rotating at 3.5m∕s linear velocity, the adequate writing and erasing of laser power are 10–15 and 4–8mW, respectively. The critical laser power for crystallization conversion is 8mW. The method used for this research can be satisfyingly applied to the development of new phase-change recording materials.