gebhart/patrepeval huggingface dataset:
Low temperature process for CMUT fabrication with wafer bonding technique (2010)

We present the successful fabrication of capacitive micromachined ultrasonic transducers (CMUTs) based on low temperature wafer bonding (<;400°C). Such a fabrication process enables the direct integration of CMUTs on top of IC substrates, and requires only two additional lithography steps for fabricating the complete CMUT. Our approach benefits from both the integrated electronics and the well-controlled performance of CMUTs with single-crystal silicon plates. The yield of the CMUTs is almost 100%, and the standard deviation of resonance frequency in air is less than 1% in the whole 4 inch wafer.
Planarized tapered waveguides for high-temperature THz quantum cascade laser frequency combs (2022)

We present a novel planarized double metal waveguide platform for high-performance THz quantum cascade laser frequency combs. The waveguides are embedded in a low-loss polymer (BCB) and have an extended top metallization, resulting in lower waveguide losses and improved RF and thermal properties. A further performance improvement is observed for waveguides with a tapered profile due to nonlinearity-enhancing effects. These free-running devices produce strong single RF beatnotes up to almost −30 dBm at 90 K, nearly three orders of magnitude stronger than for ridge devices. The improved comb performance is maintained for higher operating temperatures, with a 200 GHz comb bandwidth and a single RF beatnote above −60 dBm at a heat sink temperature of 115 K.
Validity of Reported Genetic Risk Factors for Acute Coronary Syndrome (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stary lek nasenny i jego skuteczność kliniczna w schorzeniach o podłożu neurologicznym (2020)

Zolpidem to lek nasenny o budowie niebenzodiazepinowej, który został wprowadzony do praktyki klinicznej na przełomie lat 80 i 90 XX wieku. W ciągu ostatniej dekady zolpidem wzbudził szerokie zainteresowanie, po tym jak opisano kilka przypadków klinicznych, dokumentujących regresję neurologicznych objawów udaru, przywracania sprawności motorycznej u pacjentów z chorobą Parkinsona czy przypadki wybudzenia ze stanu wegetatywnego. Niniejsza praca opisuje efekty kliniczne zaobserwowane u pojedynczych pacjentów jak i przedstawia efekty zolpidemu ocenione w pilotażowych badaniach klinicznych z udziałem małej grupy chorych. Dotychczasowe obserwacje wskazują na obiecujący potencjał terapeutyczny zolpidemu w badaniach klinicznych u subpopulacji chorych cierpiących na różnorodne zaburzenia neurologiczne. Jednakże autorzy licznych prac wskazują na konieczność prowadzenia dalszych badań klinicznych obejmujących szersze grupy chorych, celem wykazania skuteczności u większej populacji pacjentów.
Decoding Spike Trains Instant by Instant Using Order Statistics and the Mixture-of-Poissons Model (2003)

In the brain, spike trains are generated in time and presumably also interpreted as they unfold in time. Recent work (Oram et al., 1999; Baker and Lemon, 2000) suggests that in several areas of the monkey brain, individual spike times carry information because they reflect an underlying rate variation. Constructing a model based on this stochastic structure allows us to apply order statistics to decode spike trains instant by instant as spikes arrive or do not. Order statistics are time-consuming to compute in the general case. We demonstrate that data from neurons in primary visual cortex are well fit by a mixture of Poisson processes; in this special case, our computations are substantially faster. In these data, spike timing contributed information beyond that available from the spike count throughout the trial. At the end of the trial, a decoder based on the mixture-of-Poissons model correctly decoded about three times as many trials as expected by chance, compared with approximately twice as many as expected by chance using the spike count only. If our model perfectly described the spike trains, and enough data were available to estimate model parameters, then our Bayesian decoder would be optimal. For four-fifths of the sets of stimulus-elicited responses, the observed spike trains were consistent with the mixture-of-Poissons model. Most of the error in estimating stimulus probabilities is attributable to not having enough data to specify the parameters of the model rather than to misspecification of the model itself.
Chromogenic Reactions in Microanalytical Chemistry (1969)

C. F. M. Rose, M. J. Toogood, D. T. Burns, A. G. Fogg and E. J. Newman, Proc. Soc. Anal. Chem., 1969, 6, 20 DOI: 10.1039/SA9690600020
Single-molecule vibrational spectroscopy and microscopy: CO on Cu(001) and Cu(110) (1999)

Single-molecule vibrations of four isotopes of CO on Cu(001) and Cu(110) at 8 K have been measured by inelastic electron tunneling spectroscopy with the scanning tunneling microscope (STM-IETS). While the low energy hindered rotation exhibits strong intensity, the C-O stretch approaches the present detection limit of STM-IETS. By performing vibrational microscopy, the spatial distribution of the hindered rotation intensity is found to be more localized than the topographic depression in constant current images.
Antidermatophytic Action of Resorcinol Derivatives: Ultrastructural Evidence of the Activity of Phenylethyl Resorcinol against Microsporum gypseum (2016)

In this work, we evaluated the antidermatophytic activities of three resorcinol derivatives that have a history of use in dermo-cosmetic applications to discover molecules with multiple dermatological activities (i.e., multi-target drugs), thereby reducing the cost and time necessary for new drug development. The antidermatophytic activities of the three skin lighteners were evaluated relative to the known antifungal drug fluconazole on nine dermatophytes responsible for the most common dermatomycoses: <i>Microsporum gypseum</i>, <i>Microsporum canis</i>, <i>Trichophyton violaceum</i>, <i>Arthroderma cajetani</i>, <i>Trichophyton mentagrophytes</i>, <i>Epidermophyton floccosum</i>, <i>Nannizzia gypsea</i>, <i>Trichophyton rubrum</i> and <i>Trichophyton tonsurans</i>. Among the three tested resorcinols, only two showed promising properties, with the ability to inhibit the growth of all tested dermatophytes; additionally, the IC<sub>50</sub> values of these two resorcinols against the nine dermatophytes confirmed their good antifungal activity, particularly for phenylethyl resorcinol against <i>M. gypseum</i>. Ultrastructural alterations exhibited by the fungus were observed using scanning electron microscopy and transmission electron microscopy and reflected a dose-dependent response to treatment with the activation of defence and self-preservation strategies.
Principled animation of artificial intelligence algorithms (2002)

Visualization is an important component of modern computing. By animating the course of an algorithm's temporal execution, many key features can be elucidated. The author has developed a general framework, termed Call-Graph Caching (CGC), for automating the construction of many complex AI algorithms. By incorporating visualization into CGC interpreters, principled animations can be automatically displayed as AI computations unfold. Systems that support the automation animation of AI algorithms must address these three design issues: how to represent AI data structures in a general, uniform way that leads to perspicuous animation and efficient redisplay; how to coordinate the succession of graphical events; and how to partition AI graphs to provide for separate, uncluttered displays. CGC provides a natural and effective solution to all these concerns. The author describes the CGC method, including detailed examples, and discusses why CGC works well for animation. He discusses the CACHE system, the CGC environment for AI algorithm animation. Finally, the author demonstrates the animation of several AI algorithms-RETE match, linear unification, arc consistency, chart parsing, and truth maintenance-all of which have been implemented in CACHE.
Mathematical description of microbiological reactions involving intermediates (2000)

Stoichiometric relationships for biological reactions involving intermediate formation are developed from microbial reaction fundamentals and thermodynamic principles. Biological reactions proceed through intermediates, which sequester carbon and electrons whenever their degradation is relatively slow. Modeling intermediate formation and subsequent utilization requires evaluation of the distribution of electrons, energy, and macronutrients (C and N) between energy-generating pathways and cell-synthesis pathways for each step in the mineralization of the primary electron-donor substrate. We describe how energy and electron balances are utilized to predict the stoichiometry for each step of a multi-step degradation process. Each stoichiometric relationship developed predicts substrate utilization, cell growth, and the formation of other products (e.g., H2CO3 or H+) for one step in the pathway to full mineralization. A modeling example demonstrates how different kinetics for each step in the degradation of nitrilotriacetic acid (NTA) leads to observed patterns in experimental results, such as a delay in the release of H2CO3 after NTA is removed from solution. © 2000 John Wiley & Sons, Inc. Biotechnol Bioeng 67: 35–52, 2000.
Advanced diffuse reflectance spectroscopy for studies of photochromic/photoactive solids (2019)

The present article reports novel opportunities of diffuse reflectance (DR) spectroscopy extended through the use of a cryostat accessory for UV-vis-NIR spectrophotometers to investigate temperature dependences of DR spectra at the fundamental absorption edge of semiconductors at T = 90-600 K. Examined are rutile TiO<sub>2</sub>, a photochromic rutile TiO<sub>2</sub> with strong absorption in the visible region, and the halide double perovskite Cs<sub>2</sub>AgBiBr<sub>6</sub> that exhibited two optical band-to-band transitions in low-temperature DR spectra. Also reported are DR spectral and kinetics measurements of the separation of photogenerated charge carriers in various trap sites, their thermostimulated detrapping and their recombination in two different photochromic materials. The similarity between absorption and temperature-programmed annealing (TPA) spectra induced in the UV and Vis regions yielded physical evidence of the photo-formation of charge carriers upon Vis-light excitation of intrinsic defects (F-type centers) in yellow rutile TiO<sub>2</sub>. High-temperature oxidative/reductive treatments of samples, together with spectral and kinetics measurements were performed in situ with the accessory. Results led to assigning color centers in yellow TiO<sub>2</sub> to Ti<sup>3+</sup> centers as deep electron traps, and to the establishment of several types of Ti<sup>3+</sup>-based color centers that include extra-negatively charged Ti <sup>δ+</sup> centers (3 > δ > 2). Photochromic occurrences are also elucidated in the Bi-doped perovskite CsPbBr<sub>3</sub> under illumination in the region of intrinsic absorption and annealing of photoinduced absorption at T = 200-400 K. These phenomena are described in terms of the photogeneration of charge carriers followed by their trapping, which yielded Bi-related electron color centers responsible for the photoinduced absorption and for the thermostimulated detrapping of photoholes that ultimately recombine with the trapped electrons. The establishment of photochromism in the perovskites may lead to a further understanding of photoinduced and dark reversible phenomena in halide perovskites and halide perovskite-based solar cells.
Antimicrobial herbs against Staphylococcus aureusa and Propionibacterium acnes (2010)

Acne is a common skin condition in adolescence and usually resulted in scarring. Its main effects are psychological, like self-esteem reduction and depression. Pathogenesis of acne are four major factors, including increased sebum production by overactive oil glands, retention hyperkeratosis to block the skin pores, activity of normal skin bacteria (Staphylococcus aureus and Propionibacterium acnes) and inflammation. In this study, 30 herbal plants were extracted by 50% methanol, and the anti-S. aureusa activity of herb extracts were evaluated. The results showed 50% methanol extracts of 7 herbal plants had more significant activity than the others, while the clear zone of Hydrocotyle verticillata, Acanthopanax trifoliatus, Wikstroemia indica, Berchemia lineata were all 11.0mm; Origanum majorana was 11.5mm; Salvia plebeia was 13.0mm and Myristica fragrans was 13.5mm. Among the 30 herb extracts, M. fragrans displayed the strongest anti-S. aureus activity and the minimum inhibitory concentration (MIC) was 0.64mg. P. acnes was also pathogenesis of acne and was used as target bacteria in this study. The MIC of M. fragrans 50% methanol extract was 0.64mg against P. acnes. M. fragrans, a high essential oil content spice, showed potential antimicrobial activity and anti-inflammation effects in vitro and in vivo. The essential oils of M. fragrans were extracted by hydrodistillation and analyzed by GC-MS. In agar well-diffusion method, the MIC of the essential oil from M. fragrans against S. aureusa and P. acnes were 80% and 20%, respectively. Therefore, we suggested that M. fragrans were a potential material to develop anti-acne cosmetics.
Improvement of absorption characteristics and reduction of irritation on stomach of flurbiprofen by complexation with various cyclodextrins. (1987)

Flurbiprofen (FP), nonsteroidal antiinflammatory drug, is poorly soluble in water and sometimes causes an adverse reaction due to a stimulant property to stomach after oral administration. The inclusion complexes of FP with natural β-and γ-cyclodextrin (β-, γ-CyD) or methylated β-CyD, heptakis(2, 6-di-O-methyl)-β-CyD (DM-β-CyD) and heptakis(2, 3, 6-tri-O-methyl)-β-CyD (TM-β-CyD), in a 1:1 molar ratio were prepared, and then their dissolution, absorption characteristics and the irritation of the gastric mucosa of rats were compared with those of FP. The dissolution rate of FP from capsules in JP XI No. 1 was significantly increased by the inclusion complexation (γ->DM-β->β->TM-β-CyD complex>FP alone). The serum levels of FP following the oral administration in form of complex to rats are higher than after the drug alone (DM-β-≈γ->β->TM-β-CyDcomplex> FP alone). The gastric damages induced by a single administration of complexes with β-, γ-and TM-β-CyD were less than that of FP alone, while gastric damage induced by DM-β-CyD complex was same as FP alone. The enhanced bioavailability and reduced gastric damage of FP by complexation with natural β-and γ-CyD suggested the possibility of smaller doses and fewer adverse effects in FP therapy.
Targeted Advertising on Social Networks Using Online Variational Tensor Regression (2022)

This paper is concerned with online targeted advertising on social networks. The main technical task we address is to estimate the activation probability for user pairs, which quantifies the influence one user may have on another towards purchasing decisions. This is a challenging task because one marketing episode typically involves a multitude of marketing campaigns/strategies of different products for highly diverse customers. In this paper, we propose what we believe is the first tensor-based contextual bandit framework for online targeted advertising. The proposed framework is designed to accommodate any number of feature vectors in the form of multi-mode tensor, thereby enabling to capture the heterogeneity that may exist over user preferences, products, and campaign strategies in a unified manner. To handle inter-dependency of tensor modes, we introduce an online variational algorithm with a mean-field approximation. We empirically confirm that the proposed TensorUCB algorithm achieves a significant improvement in influence maximization tasks over the benchmarks, which is attributable to its capability of capturing the user-product heterogeneity.
Synthesis and characterization of novel orange-emitting iridium(III) complexes with diphenylquinoline ligands containing fluorinated substituent (2006)

Three new cyclometalated iridium(III) complexes based on ligands of diphenylquinoline with fluorinated substituents were prepared, and characterized by elemental analysis (EA), H-1 NMR, and mass spectroscopy (MS). The photophysical and electrophosphorescent properties of the complexes were briefly discussed.
ChemInform Abstract: Regiospecific Synthesis of N2‐Aryl 1,2,3‐Triazoles from 2,5‐Disubstituted Tetrazoles via Photochemically Generated Nitrile Imine Intermediates. (2015)

Abstract The preparation of the substrates by copper‐catalyzed coupling of 5‐aryl‐tetrazoles with aryl boronic acids to the corresponding 2,5‐diaryltetrazoles is described.
Automatic synthesis of computation interference constraints for relative timing verification (2009)

Asynchronous sequential circuit or protocol design requires formal verification to ensure correct behavior under all operating conditions. However, most asynchronous circuits or protocols cannot be proven conformant to a specification without adding timing assumptions. Relative Timing (RT) is an approach to model and verify circuits and protocols that require timing assumptions to operate correctly. The process of creating path-based RT constraints has previously been done by hand with the aid of a formal verification engine. This time consuming and error prone method vastly restricts the application of RT and the capability to implement circuits and protocols. This paper describes an algorithm for automatic generation of RT constraints based on signal traces generated from a formal verification (FV) engine that supports relative timing constraints. This algorithm has been implemented in a CAD tool called Automatic Relative Timing Identifier based on Signal Traces (ARTIST) which has been embedded into the FV engine. A set of asynchronous and clocked designs and protocols have been verified and proven to be hazard-free with the RT constraints generated by ARTIST which would have taken months to perform by hand. A comparison of RT constraints between hand-generated and ARTIST generated constraints is also described in terms of efficiency and quality.
Life History of Pink Hibiscus Mealybug,Maconellicoccus hirsutus(Hemiptera: Pseudococcidae) on ThreeHibiscusRosa-SinensisCultivars (2012)

The pink hibiscus mealybug, Maconellicoccus hirsutus Green, is a widespread invasive pest of Hibiscus rosa-sinensis in Florida and elsewhere. We evaluated 3 cultivars of H. rosa-sinensis expected to have high (‘President’), low (‘Double Red’), and intermediate (‘Joanne’) levels of susceptibility to this pest. We found little evidence that M. hirsutus responded differently among the 3 cultivars in terms of survival, development rate, size, or oviposition period in laboratory tests at a permissive temperature. However, higher average fecundity (377 eggs per female) was observed on “President” compared with the other 2 cultivars (≈ 300 eggs/female). The Fl generation developed on all varieties, with similar cumulative survival rates of 71, 74, and 76% on “Double Red”, “Joanne” and “President” cultivars, respectively. In greenhouse tests over 9 wk, feeding symptoms of stunted and deformed plant terminals (“bunchy top”) were observed in all cultivars but increased more rapidly in “President”, especially after the 4th wk post infestation. Significantly higher mealybug populations were also observed on “President” compared with the other 2 cultivars, reaching an average of ≈ 50 and 1,400 insect per terminal after the first and second generations, 30 and 60 d post infestation, respectively, on this variety. Although none of the hibiscus varieties tested were resistant to M. hirsutus in our studies, selection (or breeding) of additional cultivars tolerant to feeding symptoms may be useful in low management input landscapes for M. hirsutus infested areas, especially in conjunction with biocontrol programs.
Simulation Modeling and Analysis with ARENA (2011)

Simulation Modeling and Analysis with Arena is a highly readable textbook which treats the essentials of the Monte Carlo discrete-event simulation methodology, and does so in the context of a popular Arena simulation environment. It treats simulation modeling as an in-vitro laboratory that facilitates the understanding of complex systems and experimentation with what-if scenarios in order to estimate their performance metrics. The book contains chapters on the simulation modeling methodology and the underpinnings of discrete-event systems, as well as the relevant underlying probability, statistics, stochastic processes, input analysis, model validation and output analysis. All simulation-related concepts are illustrated in numerous Arena examples, encompassing production lines, manufacturing and inventory systems, transportation systems, and computer information systems in networked settings.· Introduces the concept of discrete event Monte Carlo simulation, the most commonly used methodology for modeling and analysis of complex systems· Covers essential workings of the popular animated simulation language, ARENA, including set-up, design parameters, input data, and output analysis, along with a wide variety of sample model applications from production lines to transportation systems· Reviews elements of statistics, probability, and stochastic processes relevant to simulation modeling* Ample end-of-chapter problems and full Solutions Manual* Includes CD with sample ARENA modeling programs
Synthesis and properties of homogeneously doped Nb2O5〈Dy〉 and a LiNbO3〈Dy〉growth charge (2014)

We have studied conditions for the synthesis of niobium pentoxide and a lithium niobate growth charge doped with dysprosium, which was added to niobium hydroxide obtained through extraction processing of rare-metal-containing raw materials. The phase composition of Nb2O5〈Dy〉 precursors was determined by X-ray diffraction and IR spectroscopy. Using inductively coupled plasma mass spectrometry in combination with a laser ablation sampling system, we examined the Dy dopant profile in Nb2O5 powder samples and the LiNbO3 growth charge. The Nb2O5 precursors and the growth charge synthesized using them were shown to be chemically uniform in composition. The present results are of importance for the growth of defect-free lithium niobate single crystals of optical quality, highly uniform in composition, with a predetermined doping level.
Study of scaling in a plate heat exchanger under guided ultrasonic waves (2021)

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