gebhart/patrepeval huggingface dataset:
Towards statistical machine learning for edge analytics in large scale networks: Real-time Gaussian function generation with generic DSP (2018)

The smart grid (SG) is a large-scale network and it is an integral part of the Internet of Things (IoT). For a more effective big data analytic in large-scale IoT networks, reliable solutions are being designed such that many real-time decisions will be taken at the edge of the network close to where data is being generated. Gaussian functions are extensively applied in the field of statistical machine learning, pattern recognition, adaptive algorithms for function approximation, etc. It is envisaged that soon, some of these machine learning solutions and other gaussian function based applications that have low computation and low-memory footprint will be deployed for edge analytics in large-scale IoT networks. Hence, it will be of immense benefit if an adaptive, low-cost, method of designing gaussian functions becomes available. In this paper, gaussian distribution functions are designed using C28x real-time digital signal processor (DSP) that is embedded in the TMS320C2000 modem designed for powerline communication (PLC) at the low voltage distribution end of the smart grid, where numerous devices that generate massive amount of data exist. Open-source embedded C programming language is used to program the C28x for real-time gaussian function generation. The designed gaussian waveforms are stored in lookup tables (LUTs) in the C28x embedded DSP, and could be deployed for a variety of applications at the edge of the SG and IoT network. The novelty of the design is that the gaussian functions are designed with a generic, low-cost, fixed-point DSP, different from state of the art in which gaussian functions are designed using expensive arbitrary waveform generators and other specialized circuits. C28x DSP is selected for this design since it is already existing as an embedded DSP in many smart grid applications and in other numerous industrial systems that are part of the large scale IoT network, hence it is envisaged that integration of any gaussian function based solution using this DSP in the smart grid and other IoT systems may not be too challenging.
Heterogeneous Nuclear Ribonucleoprotein K Is a DNA-binding Transactivator (1995)

We have previously reported that heterogeneous nuclear ribonucleoprotein K (hnRNP K) binds to the pyrimidine-rich strand of the CT element found in the human c-myc gene and activates CT reporter-driven gene expression in vivo. We now characterize the DNA and protein requirements for the interaction of hnRNP K with the CT element. First, hnRNP K is shown to preferentially bind single-stranded DNA over RNA or native double-stranded DNA. Using specific oligoribonucleotide or deoxyribonucleotide probes with specific or nonspecific RNA or DNA competitors, electrophoretic mobility shift assay revealed hnRNP K to be a DNA-binding protein. Specific binding was not simply a reflection of binding to pyrimidine-rich sequences as the number and arrangement of individual CT elements governed interactions with hnRNP K; at least two CT repeats separated by at least three nucleotides are required for binding, indicating the existence of particular stereochemical constraints regulating CT-hnRNP K complex formation. Deletion analysis showed that hnRNP K possesses several nonoverlapping, DNA binding domains, each capable of specific binding with the CT element and preferring DNA over RNA. Each sequence recognition domain is composed of at least one K homology motif, while a larger portion of hnRNP K may be required for stable RNA binding. Additional experiments indicate that the N-terminal 35 residues of hnRNP K are necessary for transactivating the CT element. These results indicate that hnRNP K is a DNA-binding protein and transcriptional activator.
Nitrogen doped fluorinated amorphous carbon thin films grown by plasma enhanced chemical vapor deposition for low dielectric constant interlayer dielectrics (1996)

Nitrogen doped fluorinated amorphous carbon thin films for low dielectric constant interlayer dielectrics have been investigated. The films were deposited with a parallel-plate plasma enhanced chemical vapor deposition. Source gases were CH4, CF4, and N2. The thermal stability of the films can be improved by the addition of N2. X-ray photoelectron spectroscopy (XPS) measurement revealed that the C-N bonds were formed in the films with the addition of N2. The dielectric constant of the films was increased from 2.1 to 2.4 at the nitrogen concentration of 10%.
Pulmonary Capillary Wedge Pressure Augments Right Ventricular Pulsatile Loading (2011)

Pulmonary hypertension and pulmonary fibrosis do not significantly change the hyperbolic dependence between R(PA) and C(PA), and patient age has only minimal effects. This fixed relationship helps explain the difficulty of reducing total right ventricular afterload by therapies that have a modest impact on mean R(PA). Higher pulmonary capillary wedge pressure appears to enhance net right ventricular afterload by elevating pulsatile, relative to resistive, load and may contribute to right ventricular dysfunction.
The Non-destructive Chemical State Analysis of Al-Cu Intermetallic Compound by Ultra-soft X-ray Spectrometer with Al L-alpha. (2007)

Extract Extended abstract of a paper presented at Microscopy and Microanalysis 2007 in Ft. Lauderdale, Florida, USA, August 5 – August 9, 2007
DFT calculations as a powerful tool for ESR spin trapping experiments (2016)

A combined electron spin resonance (ESR) and density functional theory study has been carried out to obtain deeper insight in the reaction mechanism of the photorearrangement of 3-hydroxyindolic nitrones. Also, in this case, the combination of these techniques constitutes a powerful tool when discriminating between different reaction pathways. In particular, density functional theory calculations played an important role for unraveling the overlapping of signals coming from different species in the ESR spin trapping experiments. In the present study, the computed energies and the corresponding ESR parameters of each possible isomer hypothesized have been considered, taking also into account their different possibilities of intramolecular H-bond formation. However, the results obtained indicate that the possibility of intramolecular H-bonding did not play a determinant role in this case. Copyright © 2016 John Wiley & Sons, Ltd.
High Spatial Resolution Imaging Mass Spectrometry of Human Optic Nerve Lipids and Proteins (2015)

The human optic nerve carries signals from the retina to the visual cortex of the brain. Each optic nerve is comprised of approximately one million nerve fibers that are organized into bundles of 800-1200 fibers surrounded by connective tissue and supportive glial cells. Damage to the optic nerve contributes to a number of blinding diseases including: glaucoma, neuromyelitis optica, optic neuritis, and neurofibromatosis; however, the molecular mechanisms of optic nerve damage and death are incompletely understood. Herein we present high spatial resolution MALDI imaging mass spectrometry (IMS) analysis of lipids and proteins to define the molecular anatomy of the human optic nerve. The localization of a number of lipids was observed in discrete anatomical regions corresponding to myelinated and unmyelinated nerve regions as well as to supporting connective tissue, glial cells, and blood vessels. A protein fragment from vimentin, a known intermediate filament marker for astrocytes, was observed surrounding nerved fiber bundles in the lamina cribrosa region. S100B was also found in supporting glial cell regions in the prelaminar region, and the hemoglobin alpha subunit was observed in blood vessel areas. The molecular anatomy of the optic nerve defined by MALDI IMS provides a firm foundation to study biochemical changes in blinding human diseases.
Influence of Glyphosate on Rhizoctonia Root Rot, Growth, and Yield of Barley (1992)

Time intervals between applying glyphosate to kill volunteer cereals and weeds and planting spring barley by direct drilling (no-till) into Rhizoctonia-infested soil were evaluated in field plots at Pendleton, Oregon, and Lacrosse and Lind, Washington. As the interval was shortened from autumn to spring application or from 3 wk to 3 days before planting in the spring, severity of Rhizoctonia root rot increased and grain yield decreased (.)
Possible evidence of virtual resonance in the dayside magnetosphere (2009)

On day 108, 2001, the Sub‐Auroral Magnetometer Network (SAMNET) and Magnetometers along the Eastern Atlantic Seaboard for Undergraduate Research and Education (MEASURE) magnetometer arrays detected dayside magnetic pulsations at a common frequency of ∼15 mHz at all locations below L = 4. This global pulsation event was associated with alignment of the interplanetary magnetic field with the Sun‐Earth axis, a condition known to generate ultralow‐frequency (ULF) waves in front of the bow shock. The event occurred during the early recovery phase of a geomagnetic storm. Magnetic field measured by the GOES 8 geostationary satellite on the dayside indicated elevated broadband (7–80 mHz) ULF power in the compressional component without a strong peak at 15 mHz. These observations suggest that the global pulsations originated from a compressional magnetohydrodynamic eigenmode oscillation of the inner magnetosphere stimulated by a broadband external disturbance. The equatorial Alfvén velocity corresponding to the toroidal frequencies that were determined with the cross‐phase analysis of SAMNET and MEASURE data showed a gradual decrease of the velocity with L without a clear signature of a plasmapause. The observed properties of the global pulsations are consistent with virtual resonance in the inner magnetosphere.
Double-centering method for increasing efficiency of cone-beam X-ray CT reconstruction (2005)

A method of increasing the efficiency of hardware-based circular and helical cone beam x-Ray CT reconstruction is presented. During reconstruction, an image slice at any arbitrary axial position is created by backprojecting reconstructed image pixels to corresponding positions on the detector array. This is computationally inefficient for cylindrical arrays because the backprojection equations for the channel and segment positions involve time-consuming arctangent calculations. Since the detector array matrix is smaller than the reconstruction matrix, backprojection speed can be increased if the system geometry is changed so that the arctangent calculations are performed on the detector array matrix rather than the reconstruction matrix. The most efficient configuration is where a row of reconstructed image pixels projects to a single row of detector channels with constant segment number and constant spacing along the channels. This configuration can be achieved by double centering; which consists of reprojecting the original cylindrical array projection data onto a flat virtual detector located in the xz plane. A double-centering algorithm with corresponding cone-beam reconstruction algorithm has been developed and implemented on a PC for the circular case. Cone-beam circular projection data from a ball phantom has been generated by simulation, double-centered, and reconstructed. The image quality of the double-centered reconstructions has been assessed, and the details and tradeoffs of practical implementation from an image quality standpoint are discussed.
Therapy of advanced prostate cancer with granulocyte macrophage colony-stimulating factor. (1999)

Granulocyte macrophage colony-stimulating factor is a pleiotropic cytokine capable of inducing systemic immune responses against experimental and human tumors. To evaluate the efficacy of GM-CSF treatment in patients with hormone-refractory prostate cancer, we conducted sequential Phase II studies in 36 men with progressive disease after androgen deprivation and antiandrogen withdrawal. In a first cohort of patients (n = 23), GM-CSF was administered s.c. at a dose of 250 microg/m2 daily for 14 days of a 28-day treatment period. After we observed oscillating prostate-specific antigen (PSA) responses in several patients in this first cohort, a second trial was performed in which patients (n = 13) received maintenance GM-CSF (250 microg/m2 three times weekly) after the first 14 days of daily GM-CSF. All patients were treated until disease progression. Response was assessed by evaluation of serial changes in serum PSA and sequential imaging studies. In cohort I, 10 of 22 patients (45%) had a PSA versus time plot with a sawtooth pattern, with PSA declining during GM-CSF therapy and climbing during the off-therapy period; 5 patients had at least two consecutive declines in PSA, with a median response duration of 3.5 months. All but one patient in cohort II experienced a decline in PSA (median decline, 32%), but a PSA decline greater than 50% and sustained for more than 6 weeks was seen in only one patient, who had a >99% decline in PSA and an improvement in bone scan lasting for 14+ months. Changes in PSA levels could not be attributed to direct or indirect effects of GM-CSF on the PSA assay or down-regulation of PSA expression by GM-CSF. Toxicity was very mild, consisting primarily of transient constitutional symptoms and injection site reactions. These data suggest that GM-CSF may have antitumor activity in advanced prostate cancer, and the use of GM-CSF may be a confounding variable when PSA responses are used as an end point in clinical trials evaluating new regimens for the treatment of advanced prostate cancer.
Modified cellulose acetate membranes for desalination (1984)

Abstract Residual hydroxyl groups of commercially available cellulose acetate (39.9% acetyl) have been reacted partially with phenyl isocyanate. The characteristics of these modified polymers have been studied. Membranes have been cast from these polymers to study their potentiality as reverse osmosis membranes. The work has been further extended to investigated the stability of these modified CA under the influence of high temperature and γ irradiation.
TERT Promoter Mutation as an Independent Prognostic Marker for Poor Prognosis MAPK Inhibitors-Treated Melanoma (2020)

Although the development of mitogen-activated protein kinase (MAPK) inhibitors has greatly improved the prognosis of <i>BRAF</i><sup>V600</sup> cutaneous melanomas, the identification of molecular indicators for mutated patients at risk of early progression remains a major issue. Using an amplicon-based next-generation-sequencing (NGS) assay that targets cancer-related genes, we investigated co-occurring alterations in 89 melanoma samples. We analyzed both their association with clinicopathological variables and clinical significance in terms of progression-free survival (PFS) and overall survival (OS) according to <i>BRAF</i> genotyping. Among co-occurring mutations, <i>TERT</i> promoter was the most frequently mutated gene. Although no significant difference in PFS was observed in the presence or absence of co-occurring alterations to <i>BRAF</i><sup>V600</sup>, there was a trend of longer PFS for patients harboring <i>TERT</i> c.-124C>T mutation. Of most interest, this mutation is an independent marker of good prognosis in subgroups of patients with poor prognosis (presence of brain metastasis and elevated level of lactate dehydrogenase, LDH). Moreover, combination of elevated LDH level, presence of brain metastasis, and <i>TERT</i> c.-124C>T mutation was identified as the best fit model for predicting clinical outcome. Our work revealed the potential interest of c.-124C>T status determination in order to refine the prognosis of <i>BRAF</i><sup>V600</sup> melanoma under mitogen-activated protein kinase (MAPK) inhibitors.
"Thirty days hath September" (1902)

Journal Article "Thirty days hath September" Get access O. O. H. O. O. H. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s9-X, Issue 252, 25 October 1902, Page 331, https://doi.org/10.1093/nq/s9-X.252.331d Published: 25 October 1902
Impaired innate immune response of leukocytes from ascitic fluid of patients with spontaneous bacterial peritonitis (2015)

An ascitic microenvironment can condition the immune response of cells from cirrhotic patients with spontaneous bacterial peritonitis. To characterize this response, we determined the cytokine concentrations in ascitic fluid and analyzed the phenotype and function of ascitic leukocytes at diagnosis and after antibiotic-induced resolution in sterile ascites and ascitic fluid of 2 spontaneous bacterial peritonitis variants: positive and negative bacteriological culture. At diagnosis, a high concentration was found of IL-6 and IL-10 in the ascitic fluid from negative and positive bacteriological culture. The IL-6 concentration correlated with the percentage of neutrophils (R = 0.686, P < 0.001). In this context, positive and negative culture neutrophils had an impaired oxidative burst, and, after the antibiotic, the negative culture spontaneous bacterial peritonitis burst was fully recovered. Higher concentrations of IL-6 and IL-10 correlated with the presence of low granular CD 14(low) macrophages (R = -0.436, P = 0.005 and R = 0.414, P = 0.007, respectively). Positive culture spontaneous bacterial peritonitis macrophages expressed the lowest levels of CD16, CD86, CD11b and CD206, and HLA-DR, suggesting an impaired global function. Treatment increased all markers on the positive culture macrophages and CD11b and CD86 on negative culture macrophages. In negative culture spontaneous bacterial peritonitis, this increase was accompanied by phagocytic function recovery. The antibiotics then reverted the marker levels on positive and negative culture macrophages to the levels on sterile ascitis macrophages and restored ascitic negative culture cell function.
Volume Bragg Grating Tuned Large Mode Area Fiber Laser (2008)

A narrow linewidth ytterbium-doped large-mode area VBG-tuned fiber laser is demonstrated. The output power was &gt;4.3W (77% slope efficiency) and the tuning range was 33 nm (5 GHz linewidth) with nearly diffraction limited output (M2&lt;1.3).
Novel LRR-ROC Motif That Links the N- and C-terminal Domains in LRRK2 Undergoes an Order–Disorder Transition Upon Activation (2023)

Mutations in LRRK2, a large multi-domain protein kinase, create risk factors for Parkinson's Disease (PD). LRRK2 has seven well-folded domains that include three N-terminal scaffold domains (NtDs) and four C-terminal domains (CtDs). In full-length inactive LRRK2 there is an additional well-folded motif, the LRR-ROC Linker, that lies between the NtDs and the CtDs. This motif, which is stabilized by hydrophobic residues in the LRR and ROC/COR-A domains, is anchored to the C-Lobe of the kinase domain. The LRR-ROC Linker becomes disordered when the NtDs are unleashed from the CtDs following activation by Rab29 or by various PD mutations. A key residue within the LRR-ROC Linker, W1295, sterically blocks access of substrate proteins. The W1295A mutant blocks cis-autophosphorylation of S1292 and reduces phosphorylation of heterologous Rab substrates. GaMD simulations show that the LRR-Linker motif, P + 1 loop and the inhibitory helix in the DYGψ motif are very stable. Finally, in full-length inactive LRRK2 ATP is bound to the kinase domain and GDP:Mg to the GTPase/ROC domain. The fundamentally different mechanisms for binding nucleotide (G-Loop vs P-Loop) are captured by these GaMD simulations. In this model, where ATP binds with low affinity (μM range) to N-Lobe capping residues, the known auto-phosphorylation sites are located in the space that is sampled by the flexible phosphates thus providing a potential mechanism for cis-autophosphorylation.
Green CVD—Toward a sustainable philosophy for thin film deposition by chemical vapor deposition (2021)

Thin films of materials are critical components for most areas of sustainable technologies, making thin film techniques, such as chemical vapor deposition (CVD), instrumental for a sustainable future. It is, therefore, of great importance to critically consider the sustainability aspects of CVD processes themselves used to make thin films for sustainable technologies. Here, we point to several common practices in CVD that are not sustainable. From these, we offer a perspective on several principles for a sustainable, “Green CVD” philosophy, which we hope will spur research on how to make CVD more sustainable without affecting the properties of the deposited film. We hope that these principles can be developed by the research community over time and be used to establish research on how to make CVD more sustainable and that a Green CVD philosophy can develop new research directions for both precursor and reactor design to reduce the precursor and energy consumption in CVD processes.
Palladium(II)‐Catalyzed Aerobic Intermolecular Cyclization of Acrylic Acid with Alkenes to α‐Methylene‐γ‐butyrolactones (2011)

Abstract The methodology in this article is a palladium(II)/copper(II)‐ or palladium(II)‐catalyzed intermolecular cyclization of acrylic acid with alkenes to produce α‐methylene‐γ‐butyrolactone derivatives using molecular oxygen as an environmentally benign oxidant. In this system, the carboxylato, especially trifluoroacetato, or trimethylacetato ligand, plays a quite important role to afford a high catalytic activity by suppressing the deposition of palladium(0) black.
MyWear: A Novel Smart Garment for Automatic Continuous Vital Monitoring (2021)

Wearables are getting large acceptance in the continuous monitoring of health status and physiological data. Medical devices and their connectivity through Internet along with the electronics health record (EHR) and AI analytics making smart healthcare possible. Internet-of-Medical-Things (IoMT)-end devices like wearables and implantables are key for smart healthcare. Smart garment is a specific wearable which can be used for smart healthcare. This paper presents the design and development of a smart garment called MyWear that continuously monitors and collects physiological data. It can analyze muscle activity, stress levels, and heart rate variations and send all the data to the cloud. Through abnormal variations in vitals, it can also predict the risk of heart failure and with the in-built alert system, it can notify the associated medical officials if necessary. We also propose a deep neural network model that classifies heartbeat data into abnormalities with 96.9% accuracy and 97.3% precision.
Single-Nucleotide Polymorphisms of MMP-2 Gene in Stroke Subtypes (2008)

Our study demonstrates an association of the MMP-2 gene with the development of lacunar stroke, and no association of MMP-2 with other stroke subtypes.
A Computerized System for Remote Monitoring of Subterranean Termites near Structures (2001)

Sensors comprising wooden stakes painted with conductive circuits of silver particle emulsion were inserted in Sentricon stations in soil near structures. Sensors were wired to a datalogger that was programmed to test for circuit breakage every 2 h and store the data in its memory. A host computer was programmed to access the datalogger through telephone communication lines for data download every 4 d. The computerized monitoring system was tested in three remote sites, and site visits were conducted monthly for 6 mo to examine system accuracy in detecting termite activity. The mean monthly accuracy for the system to correctly report the presence (true positive) or absence of termites (true negative) in the stations was 85%, but the accuracy at 6 mo after system installation ranged from 41 to 79%. Mean sensor longevity, defined as the time for a sensor circuit to break in the absence of termites, was ≈4.4 mo.