gebhart/patrepeval huggingface dataset:
Effects of clozapine on adipokine secretions/productions and lipid droplets in 3T3-L1 adipocytes (2017)

Clozapine, a second-generation antipsychotic (SGA), is a cause of side effects related to metabolic syndrome. The participation of serotonin 5-HT<sub>2C</sub> and histamine H<sub>1</sub> receptors in the central nervous system has been reported as a mechanism of the weight gain caused by clozapine. In the present study, we investigated the direct pharmacological action of clozapine on the 3T3-L1 adipocytes and compared it to that of blonanserin, an SGA with low affinity for both receptors. Short-term exposure to clozapine decreased secretion and mRNA expression of leptin. Long-term exposure decreased leptin as well as adiponectin secretion, and further increased lipid droplets accumulation. However, short- and long-term exposures to blonanserin did not affect these parameters. A selective serotonin 5-HT<sub>2C</sub>, but not a histamine H<sub>1</sub>, receptor antagonist enhanced the decreased secretion of leptin induced by short-term exposure to clozapine, but did not affect the increased accumulation of lipid droplets. Our findings indicate that clozapine, but not blonanserin, strongly and directly affected the secretion of adipokines, such as leptin, in adipocytes and caused adipocyte enlargement.
ChemInform Abstract: Diarylallenyliden‐Komplexe mit Pentacarbonylchrom‐ und Wolfram‐Fragmenten. (1982)

Abstract Deprotonierte Derivate von (I) reagieren mit Hexacarbonyl‐chrom bzw. ‐wolfram zu Alkinylacylat‐Komplexen (II), die durch Photolyse in die entsprechenden Alkinyl‐ 146 komplexe (III) übergeführt werden.
Atomic Layer Etching: Rethinking the Art of Etch (2018)

Atomic layer etching (ALE) is the most advanced etching technique in production today. In this Perspective, we describe ALE in comparison to long-standing conventional etching techniques, relating it to the underlying principles behind the ancient art of etching. Once considered too slow, we show how leveraging plasma has made ALE a thousand times faster than earlier approaches. While Si is the case study ALE material, prospects are better for strongly bound materials such as C, Ta, W, and Ru. Among the ALE advantages discussed, we introduce an ALE benefit with potentially broad application-the ALE smoothing effect-in which the surface flattens. Finally, regarding its well-established counterpart of atomic layer deposition (ALD), we discuss the combination of ALE and ALD in tackling real world challenges at sub-10 nm technology nodes.
Improving Brumley and Boneh timing attack on unprotected SSL implementations (2005)

Since the remarkable work of Kocher [7], several papers considering different types of timing attacks have been published. In 2003, Brumley and Boneh presented a timing attack on unprotected OpenSSL implementations [2]. In this paper, we improve the efficiency of their attack by a factor of more than 10. We exploit the timing behavior of Montgomery multiplications in the table initialization phase, which allows us to increase the number of multiplications that provide useful information to reveal one of the prime factors of RSA moduli. We also present other improvements, which can be applied to the attack in [2].
Renfield's Syndrome: A Psychiatric Illness Drawn from Bram Stoker'sDracula (2011)

The myth of vampirism is in the best of health, witness the many films (Karg, Spaite, & Sutherland, 2009; Ross, 1990), studies (Barber, 1988; Finne, 2010; Gaston, 2009; Ponnau, 1997; Pozzuoli, 2010...
Glucosamine modified near-infrared cyanine as a sensitive colorimetric fluorescent chemosensor for aspartic and glutamic acid and its applications (2014)

A near-infrared colorimetric fluorescent chemosensor has been developed and successfully applied to Glu and Asp imaging in living cells.
Practical recommendations on the use of lenalidomide in the management of myelodysplastic syndromes (2008)

Lenalidomide, an oral immunomodulatory agent, has received approval in the USA from the Food and Drug Administration (FDA) for the management of myelodysplastic syndromes (MDS) classified by the International Prognostic Scoring System (IPSS) as low risk or intermediate-1 risk and with a deletion 5q (del(5q)) cytogenetic abnormality. Although some patients with del(5q) have a relatively good prognosis, all del(5q) patients will become transfusion-dependent at some point during the course of their disease. The results of two clinical trials in more than 160 patients with MDS have demonstrated clear therapeutic benefits of lenalidomide, with >60% of patients achieving independence from transfusion during therapy, irrespective of age, prior therapy, sex, or disease-risk assessment. The recommendations presented in this review will aid the safe administration of lenalidomide for the treatment of patients with low-risk or intermediate-1-risk MDS and a del(5q) cytogenetic abnormality, and they will help physicians avoid unnecessary dose reduction or interruption, thus assuring the best efficacy for patients.
It's getting hot in here : temperature gradients inlithium-ion battery packs; Temperature gradients in lithium-ion batterypacks (2015)

A 5 channel, 40A battery cycler was constructed for
the purpose of carrying out thermal studies on Lithium-ion battery
packs. Boston Power Swing Key 442 battery blocks were tested to
determine the magnitude of the temperature gradient over the pack.
The battery blocks were stacked vertically, similar to how they
might be situated on an electric vehicle. They were cycled,
discharged then charged, at a current of 40A in stacks of one, two,
three and four, with and without unidirectional air-cooling from
the top of the pack. The resulting temperature data was analyzed to
see if a temperature gradient over the pack was present. A
correlation was found between placement in the pack and cell
temperature; the lower down in the pack a cell was, and thus the
further from the air flow, the warmer the pack became during
operation. For the four battery test, a maximum temperature
difference of 2.9°C was observed between the hottest and coldest
cells.
Robust clustering of data collected via crowdsourcing (2017)

Crowdsourcing approaches rely on the collection of multiple individuals to solve problems that require analysis of large data sets in a timely accurate manner. The inexperience of participants or annotators motivates well robust techniques. Focusing on clustering setups, the data provided by all annotators is suitably modeled here as a mixture of Gaussian components plus a uniformly distributed random variable to capture outliers. The proposed algorithm is based on the expectation-maximization algorithm and allows for soft assignments of data to clusters, to rate annotators according to their performance, and to estimate the number of Gaussian components in the non-Gaussian/Gaussian mixture model, in a jointly manner.
[Isolation of high osmotic-tolerant mutants of Escherichia coli for succinic acid production by metabolic evolution]. (2012)

Succinic acid production was inhibited by high osmotic pressure caused by the accumulation of sodium ions in the process of two-stage fermentation by Escherichia coli using Na2CO3 as the pH regulator. To enhance the resistance of this strain to osmotic stress, the possibility to isolate high NaCl-tolerant mutant strain of Escherichia coli for succinic acid production by metabolic evolution was investigated. The metabolic evolution system was used as a mutant-generating system, allowing the cells to be continuously cultured at the maximum specific growth rate. The mutant strain can grow at maximum rate in the condition of high osmotic by gradually improving the concentration of NaCl in a continuous culture. Then the high osmotic-tolerant mutant strain of E. coli XB4 was selected with NaCl as the osmo-regulator. When using Na2CO3 as the pH regulator, E. coli XB4 was used in a 7.0 L fermenter during two-stage fermentation. After 60 h anaerobic fermentation, the mutant strain XB4 produced 69.5 g/L succinic acid with a productivity of 1.18 g/(L x h), which were increased by 18.6% and 20% compared with that of the parent strain.
A Comparative Evaluation of Four Automatic Weighing Systems (1979)

AbstractFour commercially available automatic weighing systems were comparatively evaluated with a Mettler H20T semimicro balance, manually operated, serving as a control.The approach to the study was to choose 50 test units randomly from five different products (tablets and capsules) with average weights ranging from as low as 125 mg per unit to as high as 750 mg per unit. Each unit from each product was assigned a number from 1 through 50 and was weighed on all five weighing systems in a random sequence. In a second series of measurements one unit of each product, selected randomly, was weighed 20 times on each of the five weighing systems. Data from both series were statistically analyzed and evaluated.Results were similar in both series of experiments and indicated that the Cahn automatic weighing system exhibited the most variability. The Scientech automatic weighing system was the second most variable followed by the other two automatic weighing systems; Sartorius and Mettler. The Mettler H20T, the control, was the least variable. The geometric averages for each product among the weighing systems were statistically different (P≤ 0.05); however, the magnitude of these differences was considered not large enough to be of any practical pharmaceutical interest.The important features of each of the automatic weighing systems are presented and an attempt is made to explain the variabilities observed.
Relationship Between Body Weight and Total Leukocyte Count in Morbid Obesity (1985)

The authors studied the relationship between total leukocyte count and body weight in 42 morbidly obese patients (weight range, 101.5-206.8 kg). None of the patients had a recent history of infection, hematologic disorders, chronic respiratory disease, or were smoking more than 5 cigarettes/day. The range of total leukocyte count was 4.2-12.0 X 10(9) cells/L. Twelve of the 42 patients had a leukocyte count of 10 X 10(9) cells/L. There was a significant correlation between body weight (kg) and total leukocyte count (r = 0.68, P less than 0.001). Morbid obesity should be considered as one of the causes of physiologic leukocytosis.
Transient UWB antenna characterization in GTEM cells (2009)

This contribution presents a novel measurement approach to characterize the pulse reception behavior of UWB antennas using a GTEM cell. By evaluating the respective reception properties the transmit characteristics are calculated via the Lorentz's reciprocity theorem. The cell is excited at its feeding port by an UWB pulse covering a frequency range up to 10 GHz. The antenna is placed inside the testing volume. Due to the fact, that pure TEM propagation predominates within a distinct time interval, electrical small antennas can be characterized with a negligible influence of either field distortion or pulse dispersion effects. Hence, the time-gated receive signal of the antenna can be used to compute the impulse response directly via deconvolution of the incident electric field and the voltage at the antenna's feeding port.
Online mutability of step direction during rapid stepping reactions evoked by postural perturbation (2004)

Stepping reactions are often triggered rapidly in response to loss of balance. It has been unclear whether spatial step parameters are defined at time of step-initiation or whether they can be modulated online, during step execution, in response to sensory feedback about the evolving state of instability. This study explored the capacity to actively alter step direction subsequent to step initiation in six healthy young-adult subjects. To elicit forward-step reactions, subjects were released suddenly from a tethered forward lean. A second perturbation (medio-lateral support-surface translation) was applied at lags of 0-200 ms. Active reaction to the second perturbation was determined primarily through analysis of swing-leg hip-abductor activation. In addition, to gauge the biomechanical consequence of the changes in muscle activation, we compared the measured medio-lateral swing-foot displacement to that predicted by a simple passive mechanical model. Perturbations at 0-100 ms lag evoked active medio-lateral swing-foot deviation, allowing balance to be recovered with a single step. However, when the second perturbation occurred near foot-off (200-ms lag), there was no evidence of active alteration of step direction and subjects typically required additional steps to recover balance. The results suggest that step direction can be reparameterized during early stages of stepping reactions, but that step direction was not actively modulated in response to perturbation arising near start of swing phase.
Review of electrical stimulation in cerebral palsy and recommendations for future directions (2009)

Electrical stimulation (ES) for treatment of neuromuscular disorders is introduced. Various forms of ES are defined. Characteristics of cerebral palsy (CP) and treatment options are given. The clinical objectives of ES for CP treatment are stated. A review of the literature for treatment in CP is given. Several common themes within the literature and limitations in prior studies are explored. The majority of studies have used surface stimulation, which has several inherent limitations. To address these limitations, implanted devices may be used. Implanted device systems include percutaneous stimulation systems, and fully implantable leaded systems. While both of these technologies have advantages over surface stimulation, they also have their own limitations. To further address the limitations of percutaneous and fully implantable leaded systems, the Alfred Mann Foundation has developed a completely implantable, telemetered device known as the Radio Frequency Microstimulator (RFM). Results from a study using the RFM for arm rehabilitation in poststroke patients are given. A list of desirable design features for an ES system for CP is given. The next generation microstimulator device under development at the Alfred Mann Foundation is presented. This device may well serve the needs for ES in CP.
The Indigenous Microbiota and its Potential to Exhibit Probiotic Properties (2015)

Containing 33 chapters the book is an invaluable source of information and essential reading for everyone working with probiotics, prebiotics and the gut microbiotflora. Topics range from the different microorganisms used as probiotics (lactobacilli, bifidobacteria, yeast, etc) and techniques and approaches used (metagenomics, etc) to the reviews of the clinical and medical aspects.
Tratamiento conservador de la enfermedad de Müller-Weiss. A propósito de un caso (2019)

Se presenta un caso de enfermedad de Müller-Weiss en el pie izquierdo de un joven de 13 años, jugador de fútbol amateur tratado conservadoramente con plantillas ortopédicas, buscando como objetivo compensar la deformidad en varo del talón, con un seguimiento superior a 2 años. Las molestias han desaparecido, el paciente vuelve a realizar su práctica deportiva y el varismo del talón se ha compensado. Además, la anatomía radiológica es prácticamente normal.
Direct Observation of Stochastic Domain-Wall Depinning in Magnetic Nanowires (2009)

The stochastic field-driven depinning of a domain wall pinned at a notch in a magnetic nanowire is directly observed using magnetic x-ray microscopy with high lateral resolution down to 15 nm. The depinning-field distribution in Ni80Fe20 nanowires considerably depends on the wire width and the notch depth. The difference in the multiplicity of domain-wall types generated in the vicinity of a notch is responsible for the observed dependence of the stochastic nature of the domain-wall depinning field on the wire width and the notch depth. Thus the random nature of the domain-wall depinning process is controllable by an appropriate design of the nanowire.
Study of CO2 desublimation during cryogenic carbon capture using the lattice Boltzmann method (2023)

Cryogenic carbon capture (CCC) can preferentially desublimate $\text {CO}_2$ out of the flue gas. A widespread application of CCC requires a comprehensive understanding of $\text {CO}_2$ desublimation properties. This is, however, highly challenging due to the multiphysics behind it. This study proposes a lattice Boltzmann (LB) model to study $\text {CO}_2$ desublimation on a cooled cylinder surface during CCC. In two-dimensional (2-D) simulations, various $\text {CO}_2$ desublimation and capture behaviours are produced in response to different operation conditions, namely, gas velocity (Péclet number $\textit {Pe}$ ) and cylinder temperature (subcooling degree $\Delta T_{sub}$ ). As $\textit {Pe}$ increases or $\Delta T_{sub}$ decreases, the desublimation rate gradually becomes insufficient compared with the $\text {CO}_2$ supply via convection/diffusion. Correspondingly, the desublimated solid $\text {CO}_2$ layer (SCL) transforms from a loose (i.e. cluster-like, dendritic or incomplete) structure to a dense one. Four desublimation regimes are thus classified as diffusion-controlled, joint-controlled, convection-controlled and desublimation-controlled regimes. The joint-controlled regime shows quantitatively a desirable $\text {CO}_2$ capture performance: fast desublimation rate, high capture capacity, and full cylinder utilization. Regime distributions are summarized on a $\textit {Pe}$ – $\Delta T_{sub}$ space to determine operation parameters for the joint-controlled regime. Moreover, three-dimensional simulations demonstrate four similar desublimation regimes, verifying the reliability of 2-D results. Under regimes with loose SCLs, however, the desublimation process shows an improved $\text {CO}_2$ capture performance in three dimensions. This is attributed to the enhanced availability of gas–solid interface and flow paths. This work develops a reliable LB model to study $\text {CO}_2$ desublimation, which can facilitate applications of CCC for mitigating climate change.
La Nouvelle Loi Interamericaine Modele Sur Les Garanties Mobilieres De L Organisation Des Etats Americains (2002)

La Nouvelle Loi Interaméricaine Modèle Sur Les Garanties Mobilières De L´ Organisation Des Etats Américains Get access Boris Kozolchyk, Boris Kozolchyk Search for other works by this author on: Oxford Academic Google Scholar John M. Wilson John M. Wilson Search for other works by this author on: Oxford Academic Google Scholar Uniform Law Review, Volume 7, Issue 1, January 2002, Pages 130–131, https://doi.org/10.1093/ulr/7.1.130 Published: 01 January 2002
Neuropsychiatric symptoms and Quality of Life in patients with very mild and mild Alzheimer's disease (2010)

NPS are common even in the early stages of AD. NPS were significantly associated with caregiver assessment of the patient's QoL but not with patients' self-assessed QoL. Depression decreases QoL, but may remain unrecognized in AD patients, emphasizing the need for careful and structured assessment of NPS before deciding on the appropriate treatment.
Polymeric monolithic materials: Syntheses, properties, functionalization and applications (2007)

The synthetic particularities for the synthesis of polymer-based monolithic materials are summarized. In this context, monoliths prepared via thermal-, UV- or electron-beam triggered free radical polymerization, controlled TEMPO-mediated radical polymerization, polyaddition, polycondensation as well as living ring-opening metathesis polymerization (ROMP) will be covered. Particular attention is devoted to the aspects of controlling pore sizes, pore volumes and pore size distributions as well as functionalization of these supports. Finally, selected, recent applications in separation science, (bio-) catalysis and chip technology will be summarized.
2D phaseless super-resolution (2017)

In phaseless super-resolution, we only have the magnitude information of continuously-parameterized signals in a transform domain, and try to recover the original signals from these magnitude measurements. Optical microscopy is one application where the phaseless super-resolution for 2D signals arise. In this paper, we propose algorithms for performing phaseless super-resolution for 2D or higher-dimensional signals, and investigate their performance guarantees.
Análise estrutural de florestas de restinga associadas a depósitos marinhos pleistocênicos e holocênicos na Bacia do Rio Itaguaré, Bertioga (SP) (2011)

As relações entre as fitofisionomias de vegetação de Restinga e o substrato sedimentar presentes nas planícies costeiras brasileiras ainda são pouco conhecidas. Este trabalho apresenta os aspectos estruturais do componente arbóreo de dois tipos de florestas de Restinga (Floresta baixa - FbR e Floresta alta - FaR) associadas a três depósitos marinhos quaternários de diferentes gerações, presentes na planície costeira da bacia do Rio Itaguaré, em Bertioga (SP), e descreve as variações espaciais nos teores de alguns elementos químicos do solo, associados a esses remanescentes florestais. Para o estudo da vegetação foi empregado o método de parcelas, que estabelece a análise de todos os indivíduos com DAP (diâmetro à altura do peito) ≥ 10 cm. Os parâmetros levantados foram densidade, área basal e altura dos indivíduos. Os resultados mostraram que a FbR apresenta as menores amplitudes diamétricas e alturas dos indivíduos arbóreos e menor dispersão das alturas quando correlacionadas com o diâmetro (relação alométrica entre altura e DAP). Na FaR foi possível identificar variações na estrutura em função da idade do depósito marinho, do quimismo e da evolução dos solos associados, de forma que a floresta se apresenta melhor desenvolvida nos depósitos mais antigos, além de mostrar a maior correlação positiva para a relação alométrica. Percebe-se também a importância da camada orgânica depositada sobre o solo para o equilíbrio da dinâmica da ciclagem dos nutrientes disponibilizados para as plantas. De acordo com os parâmetros da legislação ambiental vigente as fitofisionomias estudadas encontram-se em estágio avançado de regeneração (FbR) e em estado primário ou nativo (FaR).