gebhart/patrepeval huggingface dataset:
Cleavage Of Oligodeoxyribonucleotides From Polymer Supports And Their Rapid Deprotection Under Microwaves (1998)

Abstract Novel conditions for the cleavage of oligodeoxynucleotides from polymer supports and their complete deprotection under microwaves have been developed. The oligonucleotides synthesized using phosphoramidite synthons carrying base labile (Pac, Dmf and t-Bpac) and conventional (Bz for A and C and Pac for G) protecing groups for nucleic bases were deprotected using 0.2M sodium hydroxide (MeOH : H2O:: 1:1, v/v) = Reagent A and 1M sodium hydroxide (MeOH: H2O :: 1:1, v/v = Reagent B, respectively under microwaves. The deprotected oligonucleotides were found to be comparable with the corresponding oligonucleotides deprotected under standard conditions (aq. ammonia at 55°C).
Neural Correlates of Incongruity (2006)

Most of the objects in our environment are familiar and expected in a given situation. A mnemonic advantage can be attributed to the distinctiveness of perceived events. Two types of distinctiveness can be distinguished: primary and secondary distinctiveness. Primary distinctiveness is due to item contrast with respect to the surroundings. The likelihood that an item will be remembered increases as the number of properties shared with its contextual neighbors decreases. Secondary distinctiveness is generated by violation of expectations about the world. Multiple behavioral studies have shown a memory advantage for incongruous versus ordinary material. This result is commonly known as the bizarreness effect. This chapter deals with secondary distinctiveness, which underlies the subjective percept of bizarreness or incongruity. The neural correlates of the encoding of incongruous information are explored in an attempt to understand why it is better remembered. Three interpretations of the bizarreness effect are considered: the attentional or processing-time hypothesis, the distinctiveness hypothesis, and the surprise or expectation violation hypothesis.
Knowledge Maps and the Presentation of Related Information Domains (1992)

Abstract An experiment was conducted to assess the relative effectiveness of multiple-relationship knowledge maps and traditional text for the presentation of related information domains. A secondary purpose was to investigate comparative versus sequential presentations. Knowledge maps were found to be superior to traditional text in acquisition and affect associated with studying for one type of material. Moreover, students in the map groups reported gaining more knowledge about their information processing and study strategies that would help them in future learning than did those in the text groups. However, these results were not replicated with respect to a second sample of text on a different topic. Subject matter and structural parameters that might account for the inability to replicate the knowledge map effect across passages are identified.
SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways (2009)

Changes in cellular ion levels can modulate distinct signaling networks aimed at correcting major disruptions in ion balances that might otherwise threaten cell growth and development. Salt-inducible kinase 1 (SIK1) and salt overly sensitive 2 (SOS2) are key protein kinases within such networks in mammalian and plant cells, respectively. In animals, SIK1 expression and activity are regulated in response to the salt content of the diet, and in plants SOS2 activity is controlled by the salinity of the soil. The specific ionic stress (elevated intracellular sodium) is followed by changes in intracellular calcium; the calcium signals are sensed by calcium-binding proteins and lead to activation of SIK1 or SOS2. These kinases target major plasma membrane transporters such as the Na(+),K(+)-ATPase in mammalian cells, and Na(+)/H(+) exchangers in the plasma membrane and membranes of intracellular vacuoles of plant cells. Activation of these networks prevents abnormal increases in intracellular sodium concentration.
VOLUMIZING HYALURONIC ACID FILLER AS TEMPORARY TISSUE EXPANDER IN LOWER EYELID CICATRICIAL ECTROPION (2017)

We describe the treatment of lower eyelid cicatricial ectropion in a 24 year old male using volumizing hyaluronic acid (HA) filler. One milliliter of Juvéderm Voluma was injected directly under the skin in each lower eyelid to create a large bubble. The filler was dissolved with hyaluronidase (750 I.U. / side) 5 months later, achieving an excellent and stable functional and cosmetic result. There was a 2.4 mm improvement in MRD-2 with the filler in place which decreased to 1.72 mm at 6 months after filler dissolution with hyaluronidase. This resulted in complete resolution of the signs and symptoms of corneal exposure. To date, there have been reports of low density HA injection for the treatment of cicatricial ectropion in elderly patients as well as infants with lamellar ichthyosis. In these cases the HA was injected and left in place to dissolve itself. Our case is the first report of a HA with high G’ properties injected directly under the skin followed by complete dissolution with hyaluronidase once the tissue expansion took place.
Accessing Postsynthetic Modification in a Series of Metal-Organic Frameworks and the Influence of Framework Topology on Reactivity (2008)

2-Amino-1,4-benzenedicarboxylic acid (NH(2)-BDC) has been found to be a compatible building block for the construction of two new metal-organic frameworks (MOFs) that have structures isoreticular to reported MOFs that use 1,4-benzenedicarboxylic acid (BDC) as a building block. DMOF-1-NH(2) (DABCO MOF-1-NH(2)) is a derivative of a previously studied MOF that contains two-dimensional square grids based on NH(2)-BDC and zinc(II) paddle-wheel units; the grid layers are connected by DABCO (1,4-diazabicyclo[2.2.2]octane) molecules that coordinate in the axial positions of the paddlewheel secondary-building units (SBUs). UMCM-1-NH(2) is an NH(2)-BDC derivative of UMCM-1 (University of Michigan Crystalline Material-1), a highly porous MOF reported by Matzger et al., and consists of both NH(2)-BDC and BTB (BTB = 4,4',4''-benzene-1,3,5-triyl-tribenzoate) linkers with Zn(4)O SBUs. The structure of UMCM-1-NH(2) was confirmed by single-crystal X-ray diffraction. By using NH(2)-BDC to generate these MOFs, the pendant amino groups can serve as a chemical handle that can be manipulated via postsynthetic modification with alkyl anhydrides. Reactions of each MOF and different anhydrides have been performed to compare the extent of conversion, thermal and structural stability, and Brunauer-Emmett-Teller surface areas afforded by the resulting materials. Under comparable reaction conditions, (1)H NMR of digested samples show that UMCM-1-NH(2) has conversions comparable to that of IRMOF-3, while DMOF-1-NH(2) only shows high conversions with smaller anhydrides. Under specific reaction conditions, higher conversions were obtained with complete retention of crystallinity, as verified by single-crystal X-ray diffraction experiments. The results presented here demonstrate three important findings: (a) NH(2)-BDC can be used as a surrogate for BDC in a number of MOFs thereby providing a handle for postsynthetic modification, (b) postsynthetic modification is a general strategy to functionalizing MOFs that can be applied to a variety of MOF structures, and (c) the topology and chemical/thermal stability of a MOF can influence the type of chemical reactions and reagents that can be used for postsynthetic modification.
WT1 Immunoprofiling and Comparison of Malignant Mullerian Mixed Tumors of The Female Genital Tract (2010)

A malignant Mullerian mixed tumor (MMMT) is a biphasic homologous or heterologous malignancy of the female genital tract. WT1 (Wilms tumor 1) is both a tumor suppressor gene and oncogene overexpressed in the nuclei of some gynecologic carcinomas. Expression in MMMT is incompletely described. Whole sections from 16 MMMTs were stained with WT1 (N terminus) using a standard immunoperoxidase technique. There were 7 heterologous and 9 homologous tumors and 10 were endometrial, 5 were ovarian, and 1 was of peritoneal origin. The tissue and cell staining pattern and score (intensity by amount) were evaluated and correlated with the tumor subtype and anatomic location. Among the 16 tumors, 81.3% showed mostly stromal and cytoplasmic staining and a score of 3 or 6. Staining was positive in 80% of the endometrial and ovarian tumors and the 1 peritoneal tumor and in all heterologous and 66.7% of the homologous tumors. The immunoprofile correlated with tumor subtype but not with anatomic location. Stromal and epithelial staining was more frequent (83.3%) in homologous tumors and differed significantly (P=0.009) from the heterologous types where stromal staining prevailed (85.7%). MMMT is another genital tract malignancy which can over express WT1 and the immunoprofile may assist in tumor subtyping.
Flexor tendon reconstruction in severely damaged hands. A two stage procedure using a silicone- Dacron reinforced gliding prosthesis prior to tendon grafting (1972)

Our experience with a Dacron-reinforced silicone tendon prosthesis in the reconstruction of flexor tendons of the hand, first reported in 1965, is brought up to date. Currently the prosthesis is usually used as a passive gliding device which is attached only to the distal phalanx. This implant, inserted as the first stage of a two-stage procedure in conjunction with excision of scar and the reconstruction of a proper pulley system, has been demonstrated to stimulate the formation of a sheath Which provides a durable gliding surface and a nutritional mechanism for a tendon graft which begins to glide early.

The indications for this procedure, as well as the preoperative, operative, and postoperative management, are described. The results in five thumbs and sixty-nine fingers, all with less than good conditions for tendon grafting (Boyes' Grades 2, 3, and 5), after follow-ups ranging from six months to eight years, are presented. The complications are also described. The results are compared with those in previously reported comparable cases.

The distinctly better results obtained in our series lead us to conclude that the two-stage procedure described is the one of choice for properly selected old injuries where the conditions are less than optimum for tendon grafting.
Switching On Luminescence by the Self‐Assembly of a Platinum(II) Complex into Gelating Nanofibers and Electroluminescent Films (2010)

A platinum(II) emitter is able to self-assemble into gelating nanofibers, leading to an unprecedented 90 % photoluminescence quantum yield. Electroluminescent devices processed in solution can be doped with the aforementioned complex. Picture: a) Emission (—) and excitation spectra (- - - -) and photos of the gel, b) REM, and c) TEM images of the nanofibers. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Photoinduced Electron Transfer Double Fragmentation: An Oxygen-Mediated Radical Chain Process in the Cofragmentation of Aminopinacol Donors with Organic Halides (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoinduced Electron Transfer Double Fragmentation: An Oxygen-Mediated Radical Chain Process in the Cofragmentation of Aminopinacol Donors with Organic HalidesLiaohai Chen, Mohammad S. Farahat, Hong Gan, Samir Farid, and David G. WhittenCite this: J. Am. Chem. Soc. 1995, 117, 23, 6398–6399Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/ja00128a046https://doi.org/10.1021/ja00128a046research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A new multi-tier adaptive military MANET security protocol using hybrid cryptography and signcryption (2010)

Mobile Ad-hoc NETworks (MANETs) are expected to play an important role in tactical military networks by providing infrastructureless communication. However, maintaining secure and instant information sharing is a difficult task especially for highly dynamic military MANETs. To address this requirement, we propose a new multi-tier adaptive military MANET security protocol using hybrid cryptography and signcryption. In our protocol, we bring novelties to secure military MANET communication for three main points: Cryptographic methods used in MANETs, hybrid key management protocols and structural organization of the military MANETs. As a new approach, we use hybrid cryptography mechanisms and Elliptic Curve Pintsov-Vanstone Signature Scheme (ECPVSS) that provide security and performance advantages when compared to some traditional cryptographic methods. Furthermore, multi-leveled security approach of our protocol provides adaptive solutions according to the requirements of different military units in the MANET. We also use a hybrid key management technique that combines the benefits of both decentralized protocols with single point of failure resistivity and centralized protocols with low rekeying cost. Last, the proposed network structure facilitates certification and key management for the MANET by providing flexibility for Mobile Backbone Network (MBN) tiers.
Etude du neurodéveloppement dans un modèle expérimental de RCIU (2015)

Plenary invited conference Régulations épigénétiques.
Integrated Enzyme‐Based Biofuel Cells–A Review (2009)

Abstract Enzyme‐based biofuel cells provide versatile means to generate electrical power from biomass or biofuel substrates, and to use biological fluids as fuel‐sources for the electrical activation of implantable electronic medical devices, or prosthetic aids. This review addresses recent advances for assembling biofuel cells based on integrated, electrically contacted thin film‐modified enzyme electrodes. Different methods to electrically communicate the enzymes associated with the anodes/cathodes of the biofuel cell elements are presented. These include: (i) The reconstitution of apo‐enzymes on relay‐cofactor monolayers assembled on electrodes, or the crosslinking of cofactor‐enzyme affinity complexes assembled on electrodes. (ii) The immobilisation of enzymes in redox‐active hydrogels associated with electrodes. (iii) The use of nano‐elements, such as carbon nanotubes, for the electrical contacting of the enzyme electrodes comprising the biofuel cells. All three methods are implemented for the electrical contacting of oxidases and dehydrogenases with electrodes acting as anodes of biofuel cells, and for the electrical wiring of bilirubin oxidase, cytochrome oxidase, and laccase with electrodes, that yield the cathode units of the biofuel cells. Different methods to control the biofuel cells, operation by external stimuli are discussed, including the application of external magnetic fields, and the electrochemical switching of the biofuel cell operation.
Planning Feature of Open Classroom in Open Elementary School - Focused on the Open Space - (1999)

This study aims to suggest guidelines of open classroom in open elementary school. It consists of following three parts. The first part takes a theoretical review of open education and open classroom. And the second makes analysis of architectural characteristics of open classroom as case studies which are analyzed in terms of modul, function and ratio of open space, etc. The last part is user need analysis of the open space.
Prognostic impact of cytogenetic abnormalities in patients with de novo acute nonlymphocytic leukemia (1989)

Detailed cytogenetic analyses were performed on specimens from 198 patients with de novo acute nonlymphocytic leukemia (ANLL), including high-resolution banding studies in 79 patients. One hundred ninety-two patients received induction therapy with daunorubicin and cytosine arabinoside (Ara-C) with an overall complete response rate (CR) of 63%. Responding patients received repetitive cycles of Ara-C-based intensification therapy. Clonal abnormalities were detected in 69% of the patients with specimens adequate for cytogenetic analysis. Certain cytogenetic changes were closely associated with French-American-British (FAB) morphology, age, and outcome: t(8;21) (closely associated with FAB M2), t(15;17) (associated with FAB M3), and abn 16q22 (associated with FAB M4EOS) tended to occur in younger patients and were associated with favorable outcomes in terms of both CR rate and long-term disease-free survival. In contrast, 19% of patients who had -5/5q- and or -7/7q- and seven patients with trisomy 8 were older, had a poor prognosis, and usually failed to achieve remission (CR) because of chemotherapy-resistant leukemia. The adverse effect on CR rate and duration in this group of patients was independent of age, and there was no association with particular morphologic subtypes. These data suggest that cytogenetic findings should influence future therapeutic choices. In particular, patients with abnormalities associated with poor responses may be considered for investigational approaches and may also provide insights into mechanisms of drug resistance.
Delta‐tocotrienol suppresses Notch‐1 pathway by upregulating miR‐34a in nonsmall cell lung cancer cells (2012)

MicroRNAs (miRNAs) are small noncoding RNAs that play critical roles in regulating various cellular functions by transcriptional silencing. miRNAs can function as either oncogenes or tumor suppressors (oncomirs), depending on cancer types. In our study, using miRNA microarray, we observed that downregulation of the Notch-1 pathway, by delta-tocotrienol, correlated with upregulation of miR-34a, in nonsmall cell lung cancer cells (NSCLC). Moreover, re-expression of miR-34a by transfection in NSCLC cells resulted in inhibition of cell growth and invasiveness, induction of apoptosis and enhanced p53 activity. Furthermore, cellular mechanism studies revealed that induction of miR-34a decreased the expression of Notch-1 and its downstream targets including Hes-1, Cyclin D1, Survivin and Bcl-2. Our findings suggest that delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit NSCLC cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents.
Green Tea Upregulates the Low-Density Lipoprotein Receptor through the Sterol-Regulated Element Binding Protein in HepG2 Liver Cells (2001)

Green tea from Camellia sinensis lowers plasma cholesterol in animal models of hypercholesterolemia. The aim of this study was to determine the effects of green tea on the expression of the hepatic low-density lipoprotein (LDL) receptor, a cell surface protein involved in the control of plasma cholesterol. Incubating human HepG2 liver cells in culture with green tea increased both LDL receptor binding activity and protein. An ethyl acetate extract of green tea, containing 70% (w/w) catechins, also increased the LDL receptor binding activity, protein, and mRNA, indicating that (1) the effect was at the level of gene transcription and that (2) the catechins were the active constituents. The mechanism by which green tea up-regulated the LDL receptor was then investigated. Green tea decreased the cell cholesterol concentration (-30%) and increased the conversion of the sterol-regulated element binding protein (SREBP-1) from the inactive precursor form to the active transcription-factor form. Consistent with this, the mRNA of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis, was also increased by green tea. In conclusion, green tea up-regulated the LDL receptor in HepG2 cells. The effect was most likely mediated through SREBP-1 in response to a decrease in the intracellular cholesterol concentration. The LDL receptor may therefore play a role in the hypocholesterolemic effect of green tea in vivo.
Spatial SQL: a query and presentation language (1994)

Recently, attention has been focused on spatial databases, which combine conventional and spatially related data, such as geographic information systems, CAD/CAM, or VLSI. A language has been developed to query such spatial databases. It recognizes the significantly different requirements of spatial data handling and overcomes the inherent problems of the application of conventional database query languages. The spatial query language has been designed as a minimal extension to the interrogative part of SQL and distinguishes from previously designed SQL extensions by: the preservation of SQL concepts; the high-level treatment of spatial objects; and the incorporation of spatial operations and relationships. It consists of two components, a query language to describe what information to retrieve and a presentation language to specify how to display query results. Users can ask standard SQL queries to retrieve nonspatial data based on nonspatial constraints, use Spatial SQL commands to inquire about situations involving spatial data, and give instructions in the Graphical Presentation Language, GPL to manipulate or examine the graphical presentation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
<title>Measurement of transducer directivity function</title> (2001)

A method for measuring the directivity function of transient fields with a new type of hydrophone that can be located at any convenient distance from the transducer is presented. Fields from planar and focused transducers, for both continuous wave and pulsed excitation, are measured via the new method, and the results compared against conventional measurements as well as against theoretical predictions. The directivity function for pulsed fields is best expressed as a complex directivity spectrum, and images of this fundamental transducer field characteristic are shown to encode a number of unexpected features. The definition and measurement of the directivity function, is not dependent on continuous wave or far-field conditions, and laboratory implementation of the theory is via a new type of hydrophone, with some unusual properties. It is concluded that precise and unambiguous measurement of transducer directivity patterns are straight forward to perform provided a relatively simple, but novel, technique is used. Images of the informative directivity spectrum may be obtained with ease.