gebhart/patrepeval huggingface dataset:
How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells? (2010)

Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic cells, and is a highly complex process that is still understood relatively poorly. Two conserved kinases called Cdc7 (cell division cycle 7) and cyclin-dependent kinase (CDK) are required to establish replication forks during the initiation of chromosome replication, and a key feature of this process is the activation of the replicative DNA helicase in situ at each origin of DNA replication. A series of recent studies has shed new light on the targets of Cdc7 and CDK, indicating that chromosome replication probably initiates by a fundamentally similar mechanism in all eukaryotes.
A Multi-Physics Adaptive Time Step Coupling Algorithm for Light-Water Reactor Core Transient and Accident Simulation (2020)

A new reactor core multi-physics system addresses the pellet-to-cladding heat transfer modeling to improve full-core operational transient and accident simulation used for assessment of reactor core nuclear safety. The rigorous modeling of the heat transfer phenomena involves strong interaction between neutron kinetics, thermal-hydraulics and nuclear fuel performance, as well as consideration of the pellet-to-cladding mechanical contact leading to dramatic increase in the gap thermal conductance coefficient. In contrast to core depletion where parameters smoothly depend on fuel burn-up, the core transient is driven by stiff equation associated with rapid variation in the solution and vulnerable to numerical instability for large time step sizes. Therefore, the coupling algorithm dedicated for multi-physics transient must implement adaptive time step and restart capability to achieve prescribed tolerance and to maintain stability of numerical simulation. This requirement is met in the MPCORE (Multi-Physics Core) multi-physics system employing external loose coupling approach to facilitate the coupling procedure due to little modification of constituent modules and due to high transparency of coupling interfaces. The paper investigates the coupling algorithm performance and evaluates the pellet-to-cladding heat transfer effect for the rod ejection accident of a light water reactor core benchmark.
Long‐term haematological reconstitution following BEAM and autologous transplantation of circulating progenitor cells in non‐Hodgkin's lymphoma (1997)

We report on long-term haematological recovery and clinical outcome after high-dose chemotherapy supported by circulating progenitor cells (CPC) transplantation in non-Hodgkin's lymphoma (NHL) patients, and analyse the role of variables which might influence engraftment. 63 consecutive NHL patients were enrolled in this study. Two groups of patients were considered for analysis: the first 34 patients had untreated diffuse large cell lymphoma with unfavourable prognostic factors. A second group of 29 patients underwent transplantation for resistant or relapsing NHL with low, intermediate and high grade histology. All patients received the BEAM conditioning regimen. As already reported in many studies, all patients showed a rapid haematological reconstitution. 43 patients (68%) achieved long-term complete trilineage engraftment within a median of 107 d from CPC transplantation. The neutrophil count was the first parameter reaching complete normalization, and haemoglobin was the last. Failure to meet the trilineage levels was due to lack of platelet recovery and was more frequent in patients transplanted in the setting of salvage protocols. By Kaplan-Meier analysis, the probability of a full reconstitution was 80% in patients to whom transplant was offered as part of a front-line therapy and 50% when transplant was given in the salvage programmes. Multivariate analysis showed that sustained long-term haematological reconstitution was significantly related to younger age, the time taken to achieve short-term reconstitution, and bone marrow involvement.
Selection of a Fifteen-Minute Work Load on a Treadmill and Bicycle (1972)

Abstract Four male and four female subjects were asked to select work loads on a treadmill and on a bicycle that would exhaust them if they carried out the exercise for 15 min. Heart rate, oxygen uptake, and blood samples were examined during and following the exercise to determine if any internal mechanism was informing the subject of his capability to exercise. Subjects all selected work efforts that were similar with respect to heart rate levels, energy cost, oxygen debts, and ventilation measurements when the bicycle and treadmill exercises were compared. Blood ph and HCO3 levels were only slightly affected by the exercise loads chosen by the women, while the men showed slight metabolic acidosis with work levels selected. Men chose work levels that resulted in heart rates and RQ measurements similar to the women's, while energy levels and debts were twice the level of the female subjects. The most consistent cue, regardless of sex or type of exercise, was a heart rate level of between 165 and 180 and RQ of .90. The work level selected by all subjects was carried out for 15 min. with only slight increases in measurements between the first and last minutes. All subjects felt they had selected the highest work levels they were able to do.
Statistical Inference (1993)

This classic textbook builds theoretical statistics from the first principles of probability theory. Starting from the basics of probability, the authors develop the theory of statistical inference using techniques, definitions, and concepts that are statistical and natural extensions, and consequences, of previous concepts. It covers all topics from a standard inference course including: distributions, random variables, data reduction, point estimation, hypothesis testing, and interval estimation. &nbsp;Features The classic graduate-level textbook on statistical inference Develops elements of statistical theory from first principles of probability Written in a&nbsp;lucid style accessible to anyone with some background in calculus Covers all key topics of a standard course in inference Hundreds of examples throughout to aid understanding Each chapter includes an extensive set of graduated exercises Statistical Inference, Second Edition is primarily aimed at graduate students of statistics, but can be used by advanced undergraduate students majoring in statistics who have a solid mathematics background. It&nbsp;also stresses the more practical uses of statistical theory, being more concerned with understanding basic statistical concepts and deriving reasonable statistical procedures, while less focused on formal optimality considerations. This is a reprint of the second edition originally published by Cengage Learning, Inc. in 2001.
A data‐driven examination of apathy and depressive symptoms in dementia with independent replication (2023)

We found four classes: no symptoms, apathy, depression and apathy/depression.Apathy conferred a higher probability for agitation.Apathy diagnostic criteria should include accompanying neuropsychiatric symptoms.
The hospital autopsy : a manual of fundamental autopsy practice (2010)

The history of the autopsy The future of the autopsy The role of the autopsy in medical education Autopsies and the law Religious attitudes to death and post-mortem examinations The safe and healthy autopsy Autopsies of people with high-risk infections The external examination The pathology of wounds and injuries The evisceration Dissection of the internal organs Examination of the nervous system Fetal, perinatal and infant autopsies The maternal autopsy Toxicological and biochemical analyses Microbiology of the autopsy Investigating possible anaphylactic deaths Perioperative and postoperative deaths The radiological autopsy The decomposed body and the unascertained autopsy Reconstruction of the body Autopsies and clinical audit Reports, documentation and statements
Simultaneous Measurements of Pressure and Deformation on a UCAV in the SARL (2005)

The assessment of advanced technology in the air force is becoming more reliant on the accuracy and fidelity of numerical predictions. It is expedient therefore, to validate the numerical codes upon which these assessments are based. The validation process requires the direct comparison of experimental measurements and numerical predictions. Among the issues that hinder the comparison of experimental measurements and computational predictions is the accuracy and structural integrity of the physical model. The ability to monitor the structural deformation of the model while simultaneously acquiring experimental data is of significant value. In an effort to resolve this issue, an experimental system that integrates Binary PressureSensitive Paint and Stereo Photogrammetry into a single system has been developed. Stereo Photogrammetry utilizes two images of the model to provide quantitative measurements of the displacement and deformation of the model surface. Pressure-Sensitive Paint allows nonintrusive measurements of pressure with high spatial resolution. Binary-Pressure Sensitive Paint uses a reference channel to compensate for errors that result from variations in temperature and illumination over the model surface. An added advantage of binary pressure-sensitive paint is the elimination of all but a single wind-off measurement, thus increasing tunnel productivity. Here we report the results of several experiments that demonstrate the capability of Binary PressureSensitive Paint in low speed wind tunnels. Finally, the integration of pressure and deformation measurements into a single system is demonstrated by experimental measurements of pressure and deformation on an Unmanned Combat Air Vehicle model in the Subsonic Aerodynamics Research Laboratory wind tunnel at Wright-Patterson Air Force Base.
Femtosecond fiber CPA system emitting 830 W average output power (2010)

In this Letter we report on the generation of 830 W compressed average power from a femtosecond fiber chirped pulse amplification (CPA) system. In the high-power operation we achieved a compressor throughput of about 90% by using high-efficiency dielectric gratings. The output pulse duration of 640 fs at 78 MHz repetition rate results in a peak power of 12 MW. Additionally, we discuss further a scaling potential toward and beyond the kilowatt level by overcoming the current scaling limitations imposed by the transversal spatial hole burning.
Crystallization properties of ultrathin phase change films (2008)

The crystallization behavior of ultrathin phase change films was studied using time-resolved x-ray diffraction (XRD). Thin films of variable thickness between 1 and 50nm of the phase change materials Ge2Sb2Te5 (GST), N-doped GST, Ge15Sb85, Sb2Te, and Ag- and In-doped Sb2Te were heated in a He atmosphere, and the intensity of the diffracted x-ray peaks was recorded. It was found for all materials that the crystallization temperature increases as the film thickness is reduced below 10nm. The increase depends on the material and can be as high as 200°C for the thinnest films. The thinnest films that show XRD peaks are 2nm for GST and N-GST, 1.5nm for Sb2Te and AgIn-Sb2Te, and 1.3nm for GeSb. This scaling behavior is very promising for the application of phase change materials to solid-state memory technology.
Mini‐STAR as bail‐out strategy for percutaneous coronary intervention of chronic total occlusion (2011)

The mini-STAR technique is a promising strategy for the treatment of CTO lesions, achieving a high procedural success rate and low occurrence of procedural adverse events.
Selective Amplification of rDNA Internal Transcribed Spacer Regions to DetectOphiosphaerella korraeandO. herpotricha (1994)

The internal transcribed spacer (ITS) regions of the rDNA of Ophiosphaerella herpotricha and O. korrae (=Leptosphaeria korrae) were amplified with the universal primers ITS4 and ITS5. Amplifications of genomic DNA from O. herpotricha isolates always resulted in a single 590-bp fragment, whereas amplifications of O. korrae isolates resulted in a single fragment of either 590 or 1,019 bp. Primers specific for O. herpotricha (OHITS1 and OHITS2) and O. korrae (OKITS1 and OKITS2) were derived from sequence analyses of the ITS regions. The OHITS primers amplified a 454-bp fragment from DNA of O. herpotricha but not from DNA of O. korrae or 29 other fungal or bacterial species [...]
Smart-tag based data dissemination (2002)

Monitoring wide, hostile areas requires disseminating data between fixed, disconnected clusters of sensor nodes. It is not always possible to install long-range radios in order to cover the whole area. We propose to leverage the movement of mobile individuals, equipped with smart-tags, to disseminate data across disconnected static nodes spread across a wide area. Static nodes and mobile smart-tags exchange data when they are in the vicinity of each other; smart-tags disseminate data as they move around. In this paper, we propose an algorithm for update propagation and a model for smart-tag based data dissemination. We use simulation to study the characteristics of the model we propose. Finally, we present an implementation based on Bluetooth smart-tags.
Architecture for body sensor networks (2005)

Recent advances in wireless sensor networks have facilitate the realisation of pervasive health monitoring for both homecare and hospital environments. The concept of Body Sensor Networks (BSN) has been introduced recently where miniaturised wearable or implantable wireless sensors are used for continuous monitoring of patients. To facilitate research and development in BSN, a BSN hardware development platform, called BSN node, is proposed by Imperial College London. With its compact, low power and flexible design, the BSN nodes provide a versatile developing environment for pervasive healthcare applications.
Mid-IR Supercontinuum Generation in ZBLAN Fibers with High Output Power and High Conversion Efficiency (2015)

Supercontinuum generation is performed in ZrF4-BaF2-LaF3-AlF3-NaF (ZBLAN) fibers pumped by a thulium (Tm3+)-doped silica fiber laser, which is simultaneously actively Q-switched and actively mode-locked. High power operation and efficient broadening towards the mid-IR wavelength region is presented.
NetAcet: prediction of N-terminal acetylation sites (2004)

We present here a neural network based method for prediction of N-terminal acetylation-by far the most abundant post-translational modification in eukaryotes. The method was developed on a yeast dataset for N-acetyltransferase A (NatA) acetylation, which is the type of N-acetylation for which most examples are known and for which orthologs have been found in several eukaryotes. We obtain correlation coefficients close to 0.7 on yeast data and a sensitivity up to 74% on mammalian data, suggesting that the method is valid for eukaryotic NatA orthologs.
Genomic Identification of Low-Density Granulocytes and Analysis of Their Role in the Pathogenesis of Systemic Lupus Erythematosus (2019)

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the presence of low-density granulocytes (LDGs) with a heightened capacity for spontaneous NETosis, but the contribution of LDGs to SLE pathogenesis remains unclear. To characterize LDGs in human SLE, gene expression profiles derived from isolated LDGs were characterized by weighted gene coexpression network analysis, and a 92-gene module was identified. The LDG gene signature was enriched in genes related to neutrophil degranulation and cell cycle regulation. This signature was assessed in gene expression datasets from two large-scale SLE clinical trials to study associations between LDG enrichment, SLE manifestations, and treatment regimens. LDG enrichment in the blood was associated with corticosteroid treatment as well as anti-dsDNA, low serum complement, renal manifestations, and vasculitis, but the latter two of these associations were dependent on concomitant corticosteroid treatment. In addition, LDG enrichment was associated with enrichment of gene signatures induced by type I IFN and TNF irrespective of corticosteroid treatment. Notably, LDG enrichment was not found in numerous tissues affected by SLE. Comparison with relevant reference datasets indicated that LDG enrichment is likely reflective of increased granulopoiesis in the bone marrow and not peripheral neutrophil activation. The results have uncovered important determinants of the appearance of LDGs in SLE and have emphasized the likely role of LDGs in specific aspects of lupus pathogenesis.
P08.06: Fetal renal to abdominal ratio a constant measurement throughout gestation (2014)

To evaluate whether the fetal renal to abdominal (RTA) ratio remains constant throughout pregnancy and whether this ratio can be a potential diagnostic landmark for CAKUT cases (congenital abnormalities of the kidney and urinary tract). During the study period, 119 pregnant women with a singleton normal pregnancy were eligible for the study group. In an axial view, the antero-posterior diameter of the kidney was measured at the level of the renal pelvis with a well-defined vertebral body. The abdominal diameter was measured antero-posteriorly at the same level. All measurements were performed by high-resolution trans-abdominal or a trans-vaginal transducer (according to the gestational age). The median gestational age was 30 weeks of gestation (range 14–40). Fetal RTA ratio was found to be constant throughout pregnancy from early second trimester to term. RTA ratio ranged between 0.27-0.29. CAKUT cases had a significantly higher RTA ratio as in solitary kidney(0.35),pelvic kidney (0.33), multicystic dysplastic kidneys (0.43) and beckwith wiedemann syndrome(0.47). On the other hand, in case of dysplastic kidneys a significantly lower RTA ratio was shown (0.21). Supporting information can be found in the online version of this abstract Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Prediction the clinical outcomes of cancer patients after peptide vaccination. (2019)

e14295 Background: Neoantigen vaccines can activate T-cells that specifically kill tumor cells. However, most vaccine peptides, selected either as HLA-binders or as HLA-presented epitopes, do not induce T-cell responses in HLA allele-matched individuals. We hypothesized that personal-epitopes (PEPIs) binding to multiple autologous HLA-alleles induce potent T-cell responses. Methods: Epitopes binding to single HLA and PEPIs binding to 3 autologous HLA-alleles were identified with our novel and validated PEPI Test (CE Marked) and correlated with CD8+ and CD4+ T-cell responses of (pre)malignant patients vaccinated with Synthetic Long Peptides (SLPs) in 2 clinical trials. A Model Population of 433 HLA-genotyped individuals was used to determine the percentage of subjects with PEPIs from SLPs (PEPI-Score). As a proof of principle, a personal vaccine was developed matching with 14 HLA-alleles of a cancer patient with PEPIs from 12 tumor-antigens. T-cell reactivities were tested by interferon-γ ELISPOT. Results: There was no correlation between single HLA-binding epitopes and HPV-specific T-cell responses of patients. In contrast, there was 90% and 69% agreement between HLA-class-I PEPIs and CD8+ T-cell responses (p &lt; 0.001) and HLA-class-II PEPIs and CD4+ T-cell responses (p = 0.005), respectively. PEPI-Score predicted the T-cell response rate of SLP vaccine clinical trials. As predicted by the PEPI Test, personal vaccine treatment activated tumor-specific T-cells: 91% and 100% of the vaccine peptides elicited CD8+ and CD4+ T-cell responses, respectively. Conclusions: A patient’s HLA genotype is a major determinant of vaccine responses and PEPIs are genetic biomarkers of T-cell responses. PEPI Test prediction of vaccine responses can be utilized by clinicians for selecting the vaccine treatment and for the development of highly immunogenic personal vaccines matched to a patient’s complete HLA genotype (NCT03391232).
Fluorigenic reagents for primary and secondary amines and thiols in high-performance liquid chromatography. A review (1984)

K. Imai, T. Toyo'oka and H. Miyano, Analyst, 1984, 109, 1365 DOI: 10.1039/AN9840901365
On the Electrochemical Behavior and Passivation of Copper and Brass (Cu70∕Zn30) Electrodes in Concentrated Aqueous KOH Solutions (2006)

We report on the study of the electrochemical behavior of copper and brass electrodes in concentrated aqueous solutions. Passive films are formed on the surface of anodically polarized, pure polycrystalline copper and a alloy (α-brass), in aqueous 30% (7 M) and 45% (11.7 M) electrolyte solutions, at two characteristic potentials (corresponding to the two major anodic peaks in the voltammograms of these systems). The structure and composition of the films were determined by ex situ X-ray diffraction (XRD), in situ and ex situ micro-Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and atomic force microscopy (AFM). The formation of crystalline cubic , on the surface of Cu and electrodes in highly concentrated solutions, occurs at potentials above vs a standard hydrogen electrode (SHE). A porous passive layer is formed at potentials above vs SHE on pure Cu surfaces. In a solution, this surface layer consists of , while in a solution, the surface films comprise a structure with the as the inner layer. The anodic polarization of (α-brass) leads to a complete dezincification of the surface, at potentials vs SHE, in both electrolyte solutions. Porous surface layers are formed on brass at these anodic potentials and have duplex structure, , where the content increases with an increase in the concentration. At potentials vs SHE, the layer shows a preferential orientation of (020).