gebhart/patrepeval huggingface dataset:
Targeting adenovirus gene delivery to activated tumour-associated vasculature via endothelial selectins (2010)

Clinical experience with adenovirus vectors has highlighted the need for improved delivery and targeting. Tumour-associated endothelium offers an additional mechanism for enhanced viral uptake into tumours which is accessible for systemic gene delivery. Building on expertise in using polymer 'stealthed' viruses for targeting in vivo, adenovirus expressing luciferase (Adluc) was coated with an amino-reactive polymer based on poly [N-(2-hydroxypropyl) methacrylamide] to ablate normal infection pathways. Direct linkage of a monoclonal antibody against E-selectin (MHES) demonstrated E-selectin-specific transduction of tumour necrosis factor-α (TNF-α)-activated endothelial cells. A two-component targeting system using protein G was developed, to provide optimal antibody orientation. We report an enhancement in transduction of TNF-α-activated endothelium in vitro and ex vivo in a human umbilical vein cord model using the MHES antibody. Similarly a virus retargeted using a chimeric P-selectin Glycoprotein Ligand-1-Fc fusion (PSGL-1) protein showed better circulation kinetics and significant uptake into HepG2 xenografts following systemic administration in mice, with 36-fold higher genome copies, compared with non-modified virus. Immunohistochemistry staining of tumour sections from mice treated with PSGL-1-retargeted virus showed a co-localisation of firefly luciferase with CD31 suggesting selective endothelial targeting. Employment of optimal viral modification using protein G will enable exploration and comparison of alternative targeting ligands targeting tumour-associated endothelium.
Phase I and Pharmacokinetic Study of Pemetrexed Administered Every 3 Weeks to Advanced Cancer Patients With Normal and Impaired Renal Function (2006)

Pemetrexed was well tolerated at doses of 500 mg/m2 with vitamin supplementation in patients with GFR > or = 40 mL/min. Additional studies are needed to define appropriate dosing for renally impaired patients receiving higher dose pemetrexed with vitamin supplementation.
Probing Magnetic Pulse Welding of Thin-Walled Tubes (2020)

Magnetic pulse welding is a solid-state joining technology, based on the use of electromagnetic forces to deform and to weld workpieces. Since no external heat sources are used during the magnetic pulse welding process, it offers important advantages for the joining of dissimilar material combinations. Although magnetic pulse welding has emerged as a novel technique to join metallic tubes, the dimensional consistency of the joint assembly due to the strong impact of the flyer tube onto the target tube and the resulting plastic deformation is a major concern. Often, an internal support inside the target tube is considered as a solution to improve the stiffness of the joint assembly. A detailed investigation of magnetic pulse welding of Cu-DHP flyer tubes and 11SMnPb30 steel target tubes is performed, with and without an internal support inside the target tubes, and using a range of experimental conditions. The influence of the key process conditions on the evolution of the joint between the tubes with progress in time has been determined using experimental investigations and numerical modelling. As the process is extremely fast, real-time monitoring of the process conditions and evolution of important responses such as impact velocity and angle, and collision velocity, which determine the formation of a metallic bond, is impossible. Therefore, an integrated approach using a computational model using a finite-element method is developed to predict the progress of the impact of the flyer onto the target, the resulting flyer impact velocity and angle, the collision velocity between the flyer and the target, and the evolution of the welded joint, which are usually impossible to measure using experimental observations.
The retinol esterifying enzyme LRAT supports cell signaling by retinol‐binding protein and its receptor STRA6 (2013)

Vitamin A, retinol, circulates in blood bound to retinol-binding protein (RBP). At some tissues, holo-RBP is recognized by a plasma membrane receptor termed STRA6, which serves a dual role: it mediates transport of retinol from RBP into cells, and it functions as a cytokine receptor that, on binding holo-RBP, activates JAK2/STAT5 signaling. As STAT target genes include SOCS3, an inhibitor of insulin receptor, holo-RBP suppresses insulin responses in STRA6-expressing cells. We have shown previously that the two functions of STRA6 are interdependent. These observations suggest factors that regulate STRA6-mediated retinol transport may also control STRA6-mediated cell signaling. One such factor is retinol metabolism, which enables cellular uptake of retinol by maintaining an inward-directed concentration gradient. We show here that lecithin:retinol acyl transferase (LRAT), which catalyzes esterification of retinol to its storage species retinyl esters, is necessary for activation of the STRA6/JAK2/STAT5 cascade by holo-RBP. In accordance, LRAT-null mice are protected from holo-RBP-induced suppression of insulin responses. Hence, STRA6 signaling, which requires STRA6-mediated retinol transport, is supported by LRAT-catalyzed retinol metabolism. The observations demonstrate that STRA6 regulates key cellular processes by coupling circulating holo-RBP levels and intracellular retinol metabolism to cell signaling.
Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A (2011)

Endogenous retroviruses (ERVs) constitute a substantial portion of mammalian genomes, and their retrotransposition activity helped to drive genetic variation, yet their expression is tightly regulated to prevent unchecked amplification. We generated a series of mouse mutants and embryonic stem (ES) cell lines carrying "deletable" and "rescuable" alleles of the lysine-specific demethylase LSD1/KDM1A. In the absence of KDM1A, the murine endogenous retrovirus MuERV-L/MERVL becomes overexpressed and embryonic development arrests at gastrulation. A number of cellular genes normally restricted to the zygotic genome activation (ZGA) period also become up-regulated in Kdm1a mutants. Strikingly, many of these cellular genes are flanked by MERVL sequences or have cryptic LTRs as promoters that are targets of KDM1A repression. Using genome-wide epigenetic profiling of Kdm1a mutant ES cells, we demonstrate that this subset of ZGA genes and MERVL elements displays increased methylation of histone H3K4, increased acetylation of H3K27, and decreased methylation of H3K9. As a consequence, Kdm1a mutant ES cells exhibit an unusual propensity to generate extraembryonic tissues. Our findings suggest that ancient retroviral insertions were used to co-opt regulatory sequences targeted by KDM1A for epigenetic silencing of cell fate genes during early mammalian embryonic development.
Effect of acute oral administration of alcohol on superoxide anion production from mouse alveolar macrophages (1993)

The production of superoxide anions (superoxide) from alveolar macrophages stimulated or not with opsonized zymosan was investigated in the mouse after acute oral administration of alcohol (6.5 g/kg). Superoxide production was assayed using a nitroblue tetrazolium (NBT) reduction and chemiluminescence assay. In the absence of opsonized zymosan, superoxide concentration was not affected 1 h after ethanol treatment but was significantly increased 15 and 24 h after treatment. In the presence of opsonized zymosan, a biphasic response was observed. Superoxide production was significantly reduced 1 and 3 h after administration but was increased 15 and 24 h after treatment. One hour after treatment, the percentage of cells that phagocytized opsonized zymosan and reduced NBT was significantly decreased, whereas 24 h after alcohol treatment, phagocytosis was normal and the percentage of cells reducing NBT was significantly increased. The activity of cytosolic superoxide dismutase from alveolar macrophages was not altered 1 h after administration but was significantly reduced 24 h later. Considering the functions of alveolar macrophages in the defense of the lung, these alterations in the production of reactive oxygen species after ingestion of alcohol could explain why alcoholics are more sensitive to pulmonary infections.
Linear solvation energy relationship development for adsorption of synthetic organic compounds by carbon nanomaterials: an overview of the last decade (2020)

The LSER models for adsorption of SOCs by CNMs profoundly depend on compound properties, adsorbent characteristics and the background solution.
Ten-year clinical outcomes in N0 ER+ breast cancer patients with Recurrence Score-guided therapy (2019)

The 21-gene Recurrence Score (RS) assay is a validated prognosticator/predictor of chemotherapy (CT) benefit in early-stage estrogen receptor (ER)-positive breast cancer (BC). Long-term data from real-life clinical practice where treatment was guided by the RS result are lacking. We performed exploratory analysis of the Clalit Health Services (CHS) registry, which included all CHS patients with node-negative ER+ HER2-negative BC who underwent RS testing between 1/2006 and 12/2009 to determine 10-year Kaplan-Meier estimates for distant recurrence/BC-specific mortality (BCSM) in this cohort. The analysis included 1365 patients. Distribution of RS results: RS 0-10, 17.8%; RS 11-25, 62.5%; RS 26-100, 19.7%. Corresponding CT use: 0, 9.4, and 69.9%. Ten-year distant recurrence rates in patients with RS 0-10, 11-25, and 26-100: 2.6% (95% confidence interval [CI], 1.1-6.2%), 6.1% (95% CI, 4.4-8.6%), and 13.1% (95% CI, 9.4-18.3%), respectively (<i>P</i> < 0.001); corresponding BCSM rates: 0.7% (95% CI 0.1-5.1%), 2.2% (95% CI, 1.3-3.7%), and 9.5% (95% CI, 6.0-14.9%) (<i>P</i> < 0.001). When the analysis included patients treated with endocrine therapy alone (95.5/87.5% of patients with RS 0-10/11-25), 10-year distant recurrence and BCSM rates for RS 0-10 patients were 2.7% (95% CI, 1.1-6.5%) and 0.8% (95% CI, 0.1-5.3%), respectively, and for RS 11-25 patients, 5.7% (95% CI, 3.9-8.3%) and 2.0% (95% CI, 1.1-3.7%), respectively. For RS 11-25 patients, no statistically significant differences were observed in 10-year distant recurrence/BCSM rates between CT-treated and untreated patients; however, this should be interpreted cautiously since the number of events was low and patients were not randomized. In conclusion, in node-negative ER+ HER2-negative BC patients, where treatment decisions in real-life clinical practice incorporated the RS, patients with RS 0-25 (~80% of patients, <10% CT use) had excellent outcomes at 10 years. Patients with RS 26-100 had high distant recurrence risk despite CT use and are candidates for new treatment approaches.
Mobile Internet Monetization: A Methodology to Monitor in Real Time the Cellular Subscriber Transactional Itinerary, from Mobile Advertising Exposure to Actual Purchase (2011)

The deployment of broadband mobile networks and the surging sales of Smart phones, tablets and 3G data keys are boosting mobile Internet usage among much wider audiences. Obtaining reliable information on mobile Internet traffic, online user behavior and mobile advertising exposure has become critical for the industry, notably the telecom and media sectors. The Network Intelligence Solution (NIS) is a new market research methodology, based on the analysis of anonymised Internet Protocol (IP) information transiting on mobile networks. This methodology enables real-time tracking of mobile Internet user traffic and behavior as well as online advertising exposure, while fully respecting the subscriber's privacy. The measurements delivered with this methodology are aiming at a two-fold objectives · Bring the most effective solution to monetize the mobile Internet space. · Deliver a future-proof universal measurement methodology that will become a "global currency unit". The objective of this research paper is to present how this new methodology delivers reliable and accurate measurements of mobile advertising exposure enhanced with socio-demographic profiling and enables monitoring of the transactional process, across the full awareness-engagement-conversion itinerary.
The long-term outcome of the modified external dacryocystorhinostomy (2017)

External dacryocystorhinostomy (DCR) is still the gold standard procedure for treating nasolacrimal duct obstruction or chronic dacryocystitis.&#x0D; Purpose: to evaluate the long-term functional outcome of the modified technique of external dacryocystorhinostomy.&#x0D; Materials. 55 patients (61 eyes) with lacrimal drainage system disorders who underwent the modified technique of external DCR between 2013-2015 were involved in the study. In this modified procedure of external DCR, anastomosis was created by suturing only anterior flaps of the lacrimal sac and nasal mucosa and excision of the posterior flaps. The mean age of the patients was 65.8 12.38 years (range, 27-87 years), including 47 females and 8 males. The mean follow-up time was 19.4 6.9 months (range, 4-33 months). The success rate was recorded during the follow-up period. Cosmetic result of surgery was interpreted by the patients.&#x0D; Results. Criteria for surgical success were defined as no or minimal intermittent epiphora, no reflux on lacrimal irrigation postoperatively and a positive functional dye test. The modified external DCR with only anterior flap anastomosis had a success rate of 93.4%. 4 patients (6.6%) had recurrence of epiphora and not patent lacrimal system to irrigation. In our study, the operation time of DCR varies from 25-40 minutes. After surgery 15 of 55 patients (27.3%) described the incision scar as invisible and 3 of 55 patients (5.5%) graded it as very visible, hypertrophic scar. Five of 55 patients (9.1%) were not satisfied with the appearance of the incision.&#x0D; Conclusion. The present study concludes that modified external DCR with anterior flaps anastomosis only is a simple, less time consuming surgical technique that is easy to perform and the outcome is comparable to conventional DCR.
A two year controlled trial examining the effectiveness of ursodeoxycholic acid in primary biliary cirrhosis (1994)

Forty-six patients with primary biliary cirrhosis from a single centre were studied in a randomized placebo-controlled trial to determine the effectiveness of ursodeoxycholic acid (UDCA) over a 2 year period. The two groups were well-matched at baseline. For each parameter, by calculating the difference between the median changes with time between the UDCA group and the placebo group, it was found that from entry, with respect to placebo, there were differences between median changes (MCD) favouring the UDCA group in bilirubin (MCD 5 mumol/L [95% confidence interval (CI) 1 to 12] at 1 year and 5 mumol/L (95% CI 1 to 9) at 2 years), alkaline phosphatase MCD 242 iu/L (95% CI 107 to 360) at 1 year and 268 iu/L (95% CI 146 to 424) at 2 years and aspartate aminotransferase MCD 26 iu/L (95% CI 12 to 41) at 1 year and 37 iu/L (95% CI 16 to 64) at 2 years. Within the UDCA group, there was long-term fall in alkaline phosphatase [median fall 116 iu/L (95% CI 93 to 378) at 2 years and aspartate aminotransferase [median fall 18 iu/L (95% CI 6 to 47) at 2 years; however, the major change in bilirubin was a modest rise over 2 years in the placebo group [median rise 2 mumol/L (95% CI 1 to 9)]. Changes in albumin, prothrombin ratio and immunoglobulins were generally minor and not significant.(ABSTRACT TRUNCATED AT 250 WORDS)
S100A12 Serum Levels and PMN Counts Are Elevated in Childhood Systemic Vasculitides Especially Involving Proteinase 3 Specific Anti-neutrophil Cytoplasmic Antibodies (2018)

<b>Objectives:</b> Chronic primary systemic vasculitidies (CPV) are a collection of rare diseases involving inflammation in blood vessels, often in multiple organs. CPV can affect adults and children and may be life- or organ-threatening. Treatments for adult CPV, although effective, have known severe potential toxicities; safety and efficacy of these drugs in pediatric patients is not fully understood. There is an unmet need for biologic measures to assess the level of disease activity and, in turn, inform treatment choices for stopping, starting, or modifying therapy. This observational study determines if S100 calcium-binding protein A12 (S100A12) and common inflammatory indicators are sensitive markers of disease activity in children and adolescents with CPV that could be used to inform a minimal effective dose of therapy. <b>Methods:</b> Clinical data and sera were collected from 56 participants with CPV at study visits from diagnosis to remission. Serum concentrations of S100A12, C-reactive protein (CRP) and hemoglobin (Hb) as well as whole blood cell counts and erythrocyte sedimentation rate (ESR) were measured. Disease activity was inferred by physician's global assessment (PGA) and the pediatric vasculitis activity score (PVAS). <b>Results:</b> Serum concentrations of standard markers of inflammation (ESR, CRP, Hb, absolute blood neutrophil count), and S100A12 track with clinically assessed disease activity. These measures-particularly neutrophil counts and sera concentrations of S100A12-had the most significant correlation with clinical scores of disease activity in those children with vasculitis that is associated with anti-neutrophil cytoplasmic antibodies (ANCA) against proteinase 3. <b>Conclusions:</b> S100A12 and neutrophil counts should be considered in the assessment of disease activity in children with CPV particularly the most common forms of the disease that involve proteinase 3 ANCA. <b>Key messages</b>: - In children with chronic primary systemic vasculitis (CPV), classical measures of inflammation are not formally considered in scoring of disease activity. - Inflammatory markers-specifically S100A12 and neutrophil count-track preferentially with the most common forms of childhood CPV which affect small to medium sized vessels and involve anti neutrophil cytoplasmic antibodies (ANCA) against proteinase-3.
Degenerate Four-Wave Mixing and Optical Bistability in Manganese-Oxide-Doped Glasses (1988)

Glasses doped with CdS x Se 1− x microcrystallites have recently attracted interest because of their large third-order nonlinearities and fast response times. [1] Optical bistability with a fast switching time has already been observed. [2] Optical nonlinear properties of CdS x Se 1− x -doped glasses are explained by the band-filling mode [3] , which is applied to the nonlinear property of other materials at frequencies around the bandgap. Thus, new glass materials doped with various microcrystallites having different bandgaps are expected to have similar nonlinear properties. However, there are few reports on nonlinear glass materials other than CdS x Se 1− x -doped glasses.
Erratum zu: Die Weiterbildungssituation in der HNO-Heilkunde in Deutschland (2021)

Ein Erratum zu dieser Publikation wurde veröffentlicht: 10.1007/s00106-020-00838-9
Heat treatment effect on 17-4PH stainless steel manufactured by Atomic Diffusion Additive Manufacturing (ADAM) (2021)

A growing interest is observed in industry for metallic additive manufacturing. Atomic Diffusion Additive Manufacturing (ADAM) is a new extrusion-based process. The mechanical behavior of metallic materials obtained via ADAM has not been analyzed much. In the present work, a microscale experimental investigation was performed to study the behavior of 17-4PH stainless steel. The effect of heat treatment on the mechanical properties of the material was also examined.
Pyridoxamine, an Inhibitor of Advanced Glycation End Product (AGE) Formation Ameliorates Insulin Resistance in Obese, Type 2 Diabetic Mice (2010)

There is a growing body of evidence that the formation and accumulation of advanced glycation end products (AGE) have been known to progress under diabetic conditions, thereby being involved in diabetic vascular complications. Further, we, along with others, have recently found AGE could disturb insulin actions in cultured adipocytes and skeletal muscles. However, the pathological role of AGE in insulin resistance in vivo is not fully understood. Therefore, in this study, we examined whether pyridoxamine, an inhibitor of AGE formation could ameliorate insulin resistance in KK-A(y) mice, a model animal of obese, type 2 diabetes. Fasting blood glucose, serum levels of insulin and AGE in KK-A(y) mice were elevated as the mice got older (from 5 weeks old to 15 weeks old). Serum levels of AGE were positively correlated with insulin (R(2)=0.3956, P=0.002) in KK-A(y) mice. Administration of pyridoxamine dose-dependently decreased fasting insulin levels and improved insulin sensitivity in KK-A(y) mice of 10 weeks old, although it did not affect fasting blood glucose levels. Our present study suggests the involvement of AGE in insulin resistance in KK-A(y) mice. Inhibition of AGE formation may be a novel therapeutic target for improving insulin resistance in diabetes with obesity.
SEDIMENTATION OF BINARY MIXTURES OF PARTICLES OF UNEQUAL DENSITIES AND OF DIFFERENT SIZES (1985)

A model is developed for the sedimentation from a suspension of two particle species of unequal densities and of different sizes. The composition and the thickness of various layers in the sediments are predicted using graphical and analytical methods. The model predictions were in excellent agreement with experimental results, when the particle size ratio was ≥ 108. When size ratio of the particles was 2.60 and 4.31 the agreement occurred in about 50 percent of the cases.
Structure of an asymmetric bridged binuclear copper(II) complex (1985)

Le μ-{N,N',N'',N''', μ-O-bis[(dimethylamino)-3 propyliminomethyl]-2,6 methyl-4 phenolato} μ-hydroxo diperchlorato de cuivre (II) monohydrate ou C 19 H 32 Cl 2 Cu 2 N 4 O 10 •H 2 O cristallise dans C2/c avec Z=8; affinement jusqu'a R=0,038. La maille asymetrique comprend le cation dinucleaire macrocyclique, deux ions perchlorate et une molecule d'eau. Pyramides quadratiques deformees autour des atomes Cu
Occurrence of microplastics in commercial marine dried fish in Asian countries (2021)

The major risk of microplastics in marine environments is the bioaccumulation in marine organisms. Plastic ingestion by marine organisms has been investigated and recently more attention has been given to microplastics in seafood. However, it is seldom reported the occurrence of microplastics in marine commercial dried fish products available for human consumption. Here, we report the occurrence of microplastics in 14different marine dried fish products from seven Asian countries. Microplastics were observed in most dried fish, with fibers representing ~80% of the total-microplastics. The major plastic polymers, identified using Micro-Raman spectroscopy, included polyethylene (35%), polyethylene terephthalate (26%), polystyrene (18%), polyvinyl chloride (12%), and polypropylene (9%). The highest count, in either per individual (1.92 ± 0.12) or per gram of dried fish (0.56 ± 0.03), were found in Etrumeus micropus from Japan. Marine dried fish, which are typically eaten whole, may contribute to the ingestion of microplastics by humans, posing potential health risks especially in Asian countries. Further studies are needed to identify the occurrence of smaller sized microplastics and nanoplastics and their potential health impacts.