gebhart/patrepeval huggingface dataset:
A Comparison of Methods Used to Calculate Extreme Water Levels (2008)

A long-term water elevation record spanning 95 years at Atlantic City, New Jersey has been systematically analyzed to determine the appropriate method to calculate the stage-frequency of extreme water elevations. The annual maximum surge is found to be uncorrelated with the annual maximum water elevation, indicating that a joint probability stochastic analysis is necessary for the determination of extreme water elevations. A statistically significant increase in the recorded annual maximum surge over the past half-century (1960–2006) is evident in the data, reflecting the possible influence of global climate change on the frequency and magnitude of extreme water levels generated by coastal storms.
GSK-3 inhibitors and their potential in the treatment of Alzheimer’s disease (2005)

Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed kinase that has emerged as a promising drug target for several diseases, including various neurological conditions, Type 2 diabetes and cancer. For this reason, a number of drug candidates are being developed to achieve very different goals, any of which could have therapeutic value in the treatment of Alzheimer’s disease (AD). The importance of GSK-3 in so many processes, however, also suggests that issues of side effects will need to be addressed before GSK-3 inhibitors can be used in the clinic. This review discusses the role of GSK-3 in the development of AD, the various approaches that have been used to inhibit GSK-3 activity and the patents describing the use of GSK-3 inhibitors in the treatment of AD.
Performance assessment of the STABLE Microgravity Vibration Isolation Flight Demonstration (1997)

This paper gives an overview of the STABLE (Suppression of Transient Acceleration By LEvitation) actively-controlled electro-magnetic microgravity isolation system developed and successfully flight-tested in orbit on the shuttle during October, 1995. STABLE, fitting entirely within a shuttle middeck locker, was developed under a cooperative agreement between National Aeronautics and Space Administration, Marshall Space Flight Center, and McDonnell Douglas Aerospace. The flight hardware was designed, fabricated, integrated, tested, and delivered for launch during a fivemonth period. A description of the operational principles, design and performance criteria as well as the hardware design itself is presented. Results of the analysis of measured flight data are presented to provide an evaluation of system performance parameters, including acceleration attenuation, assessment of sway space, system power consumption, and other factors critical to the performance of an isolation system. Lessons learned and potential design improvements and evolutions will be discussed. Preliminary analyses show that the acceleration environment aboard STABLE's isolated platform was attenuated by a factor of more than 17 between 0.1 and 100 Hz compared to ambient levels. STABLE's isolation performance appears to be limited by the noise in the accelerometers used to sense the isolated platform's acceleration and by disturbances at multiples of 10 Hz. INTRODUCTION NASA, academic, and commercial consortia are all planning on-orbit microgravity experimentation and research activities aboard virtually all manned spacecraft, including shuttle (STS), Mir, and International Space Station (ISS). These activities include investigations into protein crystal growth, semiconductor fabrication, combustion, and fluid mechanics. The designers of many of these sensitive microgravity payloads are anticipating extended quiescent periods, of up to 30 days duration, during which experimentation will be carried out undisturbed by base acceleration or g-jitter. Mechanical disturbances from crew activities, onboard equipment, acoustics, ventilation, thermal creaking, and other sources threaten to disrupt the microgravity environment for these sensitive payloads, which could reduce scientific return or production quality. Figure 1 compares the predicted vibration environment aboard ISS with the desired environment. Note that ISS analytical predictions do not include vibrations induced by fluid flow, air currents, ventilation, acoustics, experiment equipment (such as pumps, fans, switches, valves), and thermal creak. Although crew disturbances are simulated, no means exist to control crew activities. Many of these disturbance sources are especially significant at lower frequencies, where the microgravity requirement is the most demanding. One solution to this problem is vibration isolation. With these disturbances in mind, over the past five years, McDonnell Douglas Aerospace (MDA) has pursued an independent research and development program on vibration isolation. Beginning in early 1995, MDA
User selection and power schedule for downlink non-orthogonal multiple access (NOMA) system (2015)

As a promising multiple access techniques for 5th generation (5G) wireless systems, non-orthogonal multiple access (NOMA) has received many attentions recently. In this paper, we study the NOMA based downlink multi-user beamforming system, where the base station (BS) tries to transmit information to multiple user clusters and each beam serves one user cluster compromising of two users simultaneously. User selection algorithm is proposed to reduce the interference and improve the system information rate. Moreover, we also provide the user power schedule scheme to guarantee the advantage of the proposed NOMA downlink multi-user beamforming system. Simulation results show that the proposed user selection algorithm and the power schedule scheme can improve the sum-rate of NOMA based downlink multi-user system.
[Troponin release following exercise test in patients with stable angina pectoris - risk factors and prognostic significance]. (2010)

The cTnI release post ExT is more frequently observed in patients with stable CAD with ejection fraction < or = 50%, low physical activity, and max systolic blood pressure > 160 mm Hg at peak ExT. Post ExT cTnI increase in patients with stable CAD did not correlate with the number of atherosclerotic coronary vessels, and had no prognostic implications. Increase of cTnI after ExT did not have any predictive value in respect to acute coronary syndrome and/or death during long-term follow up.
Inferring IoT Device Types from Network Behavior Using Unsupervised Clustering (2019)

The Internet-of-Things (IoT) is increasingly becoming a major challenge for network administrators to monitor and manage connected devices and sensors, ranging from smart-lights to smoke-alarms and security-cameras. In addition to new device offerings, manufacturers tend to automatically perform firmware upgrade from their cloud servers to change functionalities of existing devices that are operational in the field. This makes it difficult to re-train device classification models in order to capture legitimate changes dynamically. In this paper, we develop a modular device classification architecture that allows us to dynamically accommodate legitimate changes in network IoT assets, either addition of a new device type or upgrades of existing types, without replacing the entire set of models. Our contributions are twofold: (1) We identify key traffic attributes that can be obtained from flow-level network telemetry to characterize individual IoT devices. We develop an unsupervised one-class clustering method for each device to detect its normal network behavior. (2) We tune individual device-specific clustering models and use them to classify IoT devices in real-time. We enhance our classification by developing methods for automatic conflict resolution and noise filtering. We evaluate the efficacy of our scheme by applying it to traffic traces of ten real IoT devices, and demonstrate its ability to achieve overall accuracy of more than 94%.
Friction and wear properties of pitch/resin densified carbon carbon composites used for airbrakes (2002)

By use of X ray diffractometry and scanning electron microscope (SEM), the friction and wear results obtained from MM 1000 dynamometer tests of CVI pitch/resin C/C composites were analyzed. By investigating the factors that affected the friction and wear properties, such as matrix carbon, application environment, graphitization degree and brake pressure, etc, friction and wear mechanism of carbon materials were probed. The results indicate that pitch densified CVI initially treated composite is more graphitizable with its graphitization degree up to 62%, and which results in uniform small debris easier to generate, more smooth friction curves with the coefficient of 0.3 ～ 0.4 and relatively higher linear wear and mass loss, compared with CVI/resin C/C composites. It was further proved by SEM observation that tribological behavior of C/C composite was system dependent. Factors determining the friction and wear properties such as the size of debris and its influence on friction and wear, brake pressure, graphization degree and debris film formation interacted and affected each other. The friction and wear mechanism of C/C composites under different high temperature treatments needs further research.
In vitro plant regeneration from leaf expiants of Lycopersicon esculentum (tomato) (1976)

Leaf discs from 15 mutant clones of tomato were tested for their morphogenetic response in Murashige and Skoog medium supplemented with 12 combinations of the growth regulators napthaleneacetic acid (NAA) and benzylaminopurine (BA) and 4 combinations of NAA and zeatin. The results show that either callus, shoots, roots, or shoots and roots can be produced depending upon the hormone concentrations and ratios. Plants were regenerated from 12 of the 15 varieties tested.
Light and electron microscopic studies of bone-titanium interface in the tibiae of young and mature rats (1996)

Bone-titanium contact was examined in young and mature rats on various days after insertion of pure titanium into the tibia. Under light microscopy, on the 14th day, lamellar mature bone was initially formed, and was seen to make direct contact with the titanium in both groups. In young rats on the 28th day, bone-titanium contact was greater than that in mature animals. On 1-micron sections, an amorphous zone 0.5-1.0 micron thick was found around the titanium, and a slender cell layer lay parallel to the implant, forming the superficial layer of the amorphous zone. Ultrastructurally, these slender cells were identified as osteoblastlike cells and made direct contact with the implant via a 20-50-nm thin amorphous zone. Below this cell layer, a collagen-containing, poorly mineralized zone was present and bordered by lamellar bone with a lamina limitans-like structure. However, this cell layer was absent in places, and therefore the thick amorphous zone without slender cell layer consisted ultrastructurally of a 20-50-nm thin amorphous zone and a poorly mineralized zone bordered by the lamellar bone. Sometimes this poorly mineralized zone was absent, and in such cases, the lamellar bone contacted the titanium by the thin amorphous zone formed on the lamina limitans-like structure. Thus, although bone was seen to make contact with the titanium implant, ultrastructurally a 20-50-nm thin amorphous zone, a slender cell layer, and/or a poorly mineralized zone were interposed between the bone and titanium.
Comparison of Mechanical and Tribological Properties of Nitride and Oxynitride Coatings Based on Chrome and Zirconium Obtained by Cathodic Arc Evaporation (2019)

The results of the investigation of the microstructure, crystal lattice parameter, roughness, microhardness, elasticity modulus, friction coefficient, specific volumetric wear, and adhesion strength for CrN, ZrN, Zr–O–N, and Cr–O–N coatings are presented. The coatings are formed by cathodic arc evaporation and have a cubic lattice. Addition of oxygen to the nitride CrN and ZrN coatings leads to the lattice parameter increasing and the crystallite size decreasing simultaneously. The oxynitride coatings, Cr–O–N and Zr–O–N, possess improved tribological properties in comparison with nitride coatings.
A Patient with Posterior Cortical Atrophy Possesses a Novel Mutation in the Presenilin 1 Gene (2013)

Posterior cortical atrophy is a dementia syndrome with symptoms of cortical visual dysfunction, associated with amyloid plaques and neurofibrillary tangles predominantly affecting visual association cortex. Most patients diagnosed with posterior cortical atrophy will finally develop a typical Alzheimer's disease. However, there are a variety of neuropathological processes, which could lead towards a clinical presentation of posterior cortical atrophy. Mutations in the presenilin 1 gene, affecting the function of γ-secretase, are the most common genetic cause of familial, early-onset Alzheimer's disease. Here we present a patient with a clinical diagnosis of posterior cortical atrophy who harbors a novel Presenilin 1 mutation (I211M). In silico analysis predicts that the mutation could influence the interaction between presenilin 1 and presenilin1 enhancer-2 protein, a protein partner within the γ-secretase complex. These findings along with published literature support the inclusion of posterior cortical atrophy on the Alzheimer's disease spectrum.
Enhanced Megakaryopoiesis and Platelet Activity in Hypercholesterolemic, B6-Ldlr −/− , Cdkn2a -Deficient Mice (2016)

Together, the data suggest that one or more Cdkn2a transcripts modulate platelet production and activity in the setting of hypercholesterolemia, amenable to pharmaceutical intervention. Enhanced platelet production and activation may predispose to arterial thrombosis, suggesting an explanation, at least in part, for the association of 9p21.3 and myocardial infarction.
Low-temperature bonding of laser diode chips using atmospheric-pressure plasma activation of flat topped Au stud bumps with smooth surfaces (2012)

Surface activation by atmospheric-pressure plasma has been used for low-temperature bonding of laser diode (LD) chips. Coined Au stud bumps with smooth surfaces (Ra: 1.3 nm) and Au thin film electrodes (Ra: 2.1 nm) of LD chips were activated by Ar+O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> or Ar+H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> atmospheric-pressure plasma for 30 s and bonded in ambient air at low-temperature (25-150°C). Bonding strength was high enough to exceed the strength requirement of MIL-STD-883F, method 2019 (×2). The measured results of light-current-voltage (L-I-V) characteristics of the LD chips indicated no degradation after bonding.
Suicide Notes (1993)

Detailed case reports of incidents of suicide and attempted suicide on the London Underground railway system between 1985 and 1989 were examined for the presence of suicide notes. The incidence of note-leaving was 15%. Notes provided little insight into the causes of suicide as subjectively perceived, or strategies for suicide prevention.
Supplementary Figure Legends 1-9 from The OPCML Tumor Suppressor Functions as a Cell Surface Repressor–Adaptor, Negatively Regulating Receptor Tyrosine Kinases in Epithelial Ovarian Cancer (2023)

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Electroactive polyurethane/siloxane derived from castor oil as a versatile cardiac patch, part I: Synthesis, characterization, and myoblast proliferation and differentiation (2015)

Tissue-engineered cardiac patch aims at regenerating an infarcted heart by improving cardiac function and providing mechanical support to the diseased myocardium. In order to take advantages of electroactivity, a new synthetic method was developed for the introduction of an electroactive oligoaniline into the backbone of prepared patches. For this purpose, a series of electroactive polyurethane/siloxane films containing aniline tetramer (AT) was prepared through sol-gel reaction of trimethoxysilane functional intermediate polyurethane prepolymers made from castor oil and poly(ethylene glycol). Physicochemical, mechanical, and electrical conductivity of samples were evaluated and the recorded results were correlated to their structural characteristics. The optimized films were proved to be biodegradable and have tensile properties suitable for cardiac patch application. The embedded AT moieties in the backbone of the prepared samples preserved their electroactivity with the electrical conductivity in the range of 10<sup>-4</sup> S/cm. The prepared films were compatible with proliferation of C2C12 and had potential for enhancing myotube formation even without external electrical stimulation. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 775-787, 2016.
Corrosión de armaduras embebidas en hormigón carbonatado (1981)

Not available
Atomic-scale Characterization of Restructured PtCu Nanocubes (2015)

Bimetallic nanoparticles are of increasing interest due to the mutual influence of different neighboring atoms that leads to catalytic behavior different than that of a monometallic cluster [1]. The catalytic properties of these materials are dependent on the catalyst atoms at the edge and/or corner[2], i.e., surface of the nanoparticle. Motivated by previous studies Here we have used microscopy and spectroscopy techniques to provide direct evidence of atomic-scale elemental distributions within the NCs post-synthesis gas reactions.
Composites comprising biologically-synthesized nanomaterials (2023)

The present disclosure describes composite materials containing a polymer material and a nanoscale material dispersed in the polymer material. The nanoscale materials may be biologically synthesized, such as tellurium nanorods synthesized by Bacillus selenitireducens. Composite materials of the present disclosure may have optical limiting properties and find use in optical limiting devices.
Complete sequences of organelle genomes from the medicinal plant Rhazya stricta(Apocynaceae) and contrasting patterns of mitochondrial genome evolution across asterids (2014)

Organelle genomes of Rhazya stricta provide valuable information for improving the understanding of mitochondrial genome evolution among angiosperms. The genomic data have enabled a rigorous examination of the gene transfer events. Rhazya is unique among the eight sequenced asterids in the types of events that have shaped the evolution of its mitochondrial genome. Furthermore, the organelle genomes of R. stricta provide valuable genomic resources for utilizing this important medicinal plant in biotechnology applications.
Deep Basement Construction an Auckland Case Study (1999)

Parklands Apartments is a sixteen storey hotel development on the fringe of Auckland's CBD with thirteen storeys above ground and three basement car park floors. Within the constrained site there was a steep cross fall such that the excavation on the road frontage was the full three storeys deep whilst at the back of the site the excavation was limited to a single storey. To facilitate the construction of the basement and satisfy the concerns of adjacent property owners three different construction methods were adopted bottom-up, top-down and open excavation. Soil nailing was utilised on two elevations to provide temporary support as the excavation progressed to the basement formation. The paper describes the preliminary investigations and basement construction techniques adopted. Load test results on prototype and production soil nails are presented. The influence of installation methods and the performance of the nails in terms of load displacement and wall deformations are discussed.
J164011 Study of Patterning with Surface Periodic Structures for Low Surface Damage of Counterpart (2012)

In related research, femtosecond laser-induced periodic surface structures (FLIPSSs) have been well developed to achieve grooved structures with submicron spacing (700nm) and amplitude (200nm). FLIPSSs can be formed on various kinds of materials using linearly polarized femtosecond laser pulses with low fluence that is slightly above the ablation threshold. FLIPSSs with submicron scale periodical pitch and groove depth generate extremely high load carrying capacity under submicron clearance sliding conditions However, when start-up or rest of sliding, FLIPSSs have possibilities to increase damage of counterpart surface such as wear because of little load carrying capacity. In this study, in order to decrease damage of counterpart surface, FLIPSSs were offset from the polished sliding surface, and the effect of offset depth for load carrying capacity was evaluated by both numerical analysis and ring-on-disk test using PAO4 (18.82Cp @ 37°C) as lubricant. As a result, it was confirmed that intermittent spiral FLIPSSs pattern can ease up damage of counterpart surface, although inhibit decrease of load carrying capacity.
Immune modulating drug MP1032 with SARS-CoV-2 antiviral activity in vitro: A potential multi-target approach for prevention and early intervention treatment of COVID-19 (2020)

Abstract At least since March 2020, the multiorgan disease COVID-19 has a firm grip on the world. Although most of the cases are mild, patients from risk populations could develop a cytokine storm, which is characterized by a systemic inflammatory response leading to acute respiratory distress syndrome and organ failure. The present paper will introduce the small molecule MP1032, describe its mode of action, and give rationale why it is a promising option for prevention/treatment of SARS-CoV-2-induced cytokine storm. MP1032 is a phase-pure anhydrous polymorph of 5-amino-2,3-dihydro-1,4-pthalazinedione sodium salt that exhibits good stability and bioavailability. The physiological action of MP1032 is based on a multi-target mechanism including localized, self-limiting antioxidant activities that were demonstrated in a model of lipopolysaccharide (LPS)-induced joint inflammation. Furthermore, immune-regulatory and PARP-1 modulating properties, coupled with antiviral effects against SARS-CoV-2 were shown in various cell models. Efficacy has been preclinically elucidated in LPS-induced endotoxemia, a model with excessively activated immune responses that shares many similarities to COVID-19. So far, during oral clinical development with three-months daily administrations, no serious adverse drug reactions occurred highlighting the outstanding safety profile of MP1032.
ChemInform Abstract: Palladium‐Catalyzed Decarboxylative [4 + 3] Cyclization of γ‐Methylidene‐δ‐valerolactones with 1,1‐Dicyanocyclopropanes (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Heterogeneity of oxygen delivery in normoxic and hypoxic states: a fluorometer study (1978)

An on-line, real-time histogram display of heterogeneity of oxygen delivery to perfused and in situ organs is afforded by a flying-spot fluorometer that provides excitation for either oxidized flavoprotein of the mitochondrial space or reduced pyridine nucleotide of mitochondrial and cytosolic spaces. Emission from the two fluorochromes is acquired at 10(4) to 10(5) data points/s and histograms of the fluorescence intensity versus the number of occurrences of that intensity are displayed at 1--10 times per second. The histograms show alterations of the intensity and of the degree of heterogeneity of the redox states of perfused heart with model coronary occlusion, of perfused and in situ rat liver, and of rat and gerbil models of stroke. The percentage change of oxygen delivery to the intracellular space can be calculated from the areas under the histogram.