gebhart/patrepeval huggingface dataset:
Aldosterone enhances angiotensin II receptor binding and inositol phosphate responses. (1992)

Clinical states in which angiotensin II is increased are often associated with increases in mineralocorticoids. To determine the effects of mineralocorticoids on angiotensin II action, we examined the effects of aldosterone on angiotensin II receptor expression and function in cultured rat vascular smooth muscle cells. Incubation with aldosterone resulted in concentration- and time-dependent increases in angiotensin II receptor number, without changes in binding affinity. For example, incubation with 1 microM aldosterone for 40 hours resulted in 59% increases in angiotensin II receptor number. Increases in angiotensin II receptors were dependent on protein synthesis as evidenced by the time dependency of upregulation and inhibition by cycloheximide. Incubation with aldosterone resulted in enhanced angiotensin II-stimulated phospholipase C activation, as demonstrated by increases in angiotensin II-induced inositol phosphate responses in proportion to the increases in receptor number. In addition, aldosterone prevented angiotensin II-induced downregulation of angiotensin II surface receptors and angiotensin II desensitization of inositol phosphate formation. In summary, aldosterone 1) directly increased angiotensin II receptor number, 2) increased angiotensin II-stimulated inositol phosphate responses, and 3) prevented angiotensin II-induced downregulation and desensitization. In conclusion, aldosterone may potentiate the pressor responses of angiotensin II via effects on angiotensin II receptors.
Soluble Rous Sarcoma Virus Reverse Transcriptases α, αβ, and β Purified from Insect Cells Are Processive DNA Polymerases That Lack an RNase H 3′ → 5′ Directed Processing Activity (1999)

Reverse transcriptase (RT) isolated from Rous sarcoma virus (RSV) consists of heterodimeric RTalphabeta, RTalpha, and RTbeta. The alpha subunit (63 kDa) contains an N-terminal polymerase and a C-terminal RNase H domain. The N terminus of beta (95 kDa) corresponds to alpha with the integrase domain attached to the C terminus (32 kDa). We have constructed baculoviruses expressing the genes for alpha or beta or the entire pol (99 kDa). Infection of insect cells with recombinant virus yielded highly active and soluble RSV RT enzymes that could be purified to >90% homogeneity. HPLC gel filtration showed that alpha is a dimeric enzyme that can be partially monomerized upon the addition of 45% Me(2)SO. DNA synthesis on DNA-DNA and DNA-RNA primer-templates in the presence of competitor substrates revealed that alphabeta and beta as well as alpha are processive polymerases. However, the affinity of beta and alphabeta for primer-template substrates appears to be higher than that of alpha. All RSV enzymes investigated have the potential to displace RNA-RNA duplexes more efficiently than human immunodeficiency virus type 1 RT. Unlike human immunodeficiency virus type 1 RT, RSV RTs can catalyze an initial RNase H endonucleolytic cleavage of the RNA template but not a 3' --> 5' directed processing activity.
Power Subsystem Approach for the Europa Mission (2017)

NASA is planning to launch a spacecraft on a mission to the Jovian moon Europa, in order to conduct a detailed reconnaissance and investigation of its habitability. The spacecraft would orbit Jupiter and perform a detailed science investigation of Europa, utilizing a number of science instruments including an ice-penetrating radar to determine the icy shell thickness and presence of subsurface oceans. The spacecraft would be exposed to harsh radiation and extreme temperature environments. To meet mission objectives, the spacecraft power subsystem is being architected and designed to operate efficiently, and with a high degree of reliability.
A CAF-1–PCNA-Mediated Chromatin Assembly Pathway Triggered by Sensing DNA Damage (2000)

Sensing DNA damage is crucial for the maintenance of genomic integrity and cell cycle progression. The participation of chromatin in these events is becoming of increasing interest. We show that the presence of single-strand breaks and gaps, formed either directly or during DNA damage processing, can trigger the propagation of nucleosomal arrays. This nucleosome assembly pathway involves the histone chaperone chromatin assembly factor 1 (CAF-1). The largest subunit (p150) of this factor interacts directly with proliferating cell nuclear antigen (PCNA), and critical regions for this interaction on both proteins have been mapped. To isolate proteins specifically recruited during DNA repair, damaged DNA linked to magnetic beads was used. The binding of both PCNA and CAF-1 to this damaged DNA was dependent on the number of DNA lesions and required ATP. Chromatin assembly linked to the repair of single-strand breaks was disrupted by depletion of PCNA from a cell-free system. This defect was rescued by complementation with recombinant PCNA, arguing for role of PCNA in mediating chromatin assembly linked to DNA repair. We discuss the importance of the PCNA-CAF-1 interaction in the context of DNA damage processing and checkpoint control.
New binary sequences with good aperiodic autocorrelations obtained by evolutionary algorithm (1999)

A new binary sequences for lengths up to 100 with good autocorrelation function properties are presented. The results obtained by an evolutionary algorithm are better than other known results in most cases.
Frequency bins for quantum information processing (2021)

Photons offer a myriad of bases for encoding quantum information, including such popular choices as polarization, spatial modes, and time bins. And due to frequency’s inherent stability and compatibility with optical fiber, spectral modes provide a particularly attractive Hilbert space for quantum computation. Yet control and processing of such modes can prove quite challenging, typically requiring complicated operations and strong classical pump fields. In this talk, I will describe our paradigm for universal quantum computation based on frequency-bin qubits and standard lightwave technology: electro-optic phase modulators and Fourier-transform pulse shapers. Our approach offers excellent resource scaling, parallelizability, and compatibility with fiber-optic technology. I will discuss experiments so far, including frequency-bin Hadamard and tritter gates, both with ultrahigh fidelity and broad bandwidth; quantum interference and independent spectral control of two photons in the same optical fiber; and a frequency-bin controlled-NOT, the first of its kind. Such experiments are augmented by Bayesian machine learning techniques, allowing for more detailed gate analysis than possible with conventional approaches. Finally, I will conclude with an outlook on future work, highlighting opportunities to address current challenges and summarizing the potential for our technique, not only in quantum computation proper, but also quantum interconnects, frequency-multiplexed networks, and on-chip integration.
Tris(.eta.5-cyclopentadienyl)(.mu.3-alkylidyne)trinickel clusters: preparation, characterization, and molecular structure (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTris(.eta.5-cyclopentadienyl)(.mu.3-alkylidyne)trinickel clusters: preparation, characterization, and molecular structureHerbert Lehmkuhl, Carl Krueger, Stanislaw Pasynkiewicz, and Joanna PoplawskaCite this: Organometallics 1988, 7, 9, 2038–2040Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/om00099a022https://doi.org/10.1021/om00099a022research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Complex wavenumber decomposition of cylindrical shell vibrations (1990)

An extended Prony technique for analyzing the complex wavenumber content of the velocity field on the surface of a cylinder is described and tested. Radial velocity fields at the surface of a cylinder are decomposed into circumferential harmonics of order n via the FFT yielding vn (z,ω) × exp(±4 inθ). For each n and ω, the axial (z direction) wavenumber dependence consists of a sum of exponentials of the form exp(± ikzz)), where kz, is the wavenumber. There are three types of wavenumbers present on the vibrating cylinder: pure real, pure imaginary, and complex. The real wavenumber corresponds to a freely propagating wave, the imaginary wavenumber to an evanescent or neafield term (generated at discontinuities), and the complex wavenumber to a spatially decaying oscillatory wave. These complex wavenumbers cannot be determined from an axial FFT (as they are in the circumferential case). However, the extended Prony algorithm does extract the imaginary and the complex wavenumbers and determines the amplitudes of excitation of the associated waves. The effectiveness of this algorithm is demonstrated by decomposing the velocity of synthetic data. The effects of measurement noise and structural discontinuites are examined. Applications to experimental data are discussed.
Expression Analysis Of Asthma Candidate Genes During Human And Murine Lung Development (2011)

Little is known about the role of most asthma susceptibility genes during human lung development. Genetic determinants for normal lung development are not only important early in life, but also for later lung function. To investigate the role of expression patterns of well-defined asthma susceptibility genes during human and murine lung development. We hypothesized that genes influencing normal airways development would be over-represented by genes associated with asthma. Asthma genes were first identified via comprehensive search of the current literature. Next, we analyzed their expression patterns in the developing human lung during the pseudoglandular (gestational age, 7-16 weeks) and canalicular (17-26 weeks) stages of development, and in the complete developing lung time series of 3 mouse strains: A/J, SW, C57BL6. In total, 96 genes with association to asthma in at least two human populations were identified in the literature. Overall, there was no significant over-representation of the asthma genes among genes differentially expressed during lung development, although trends were seen in the human (Odds ratio, OR 1.22, confidence interval, CI 0.90-1.62) and C57BL6 mouse (OR 1.41, CI 0.92-2.11) data. However, differential expression of some asthma genes was consistent in both developing human and murine lung, e.g. NOD1, EDN1, CCL5, RORA and HLA-G. Among the asthma genes identified in genome wide association studies, ROBO1, RORA, HLA-DQB1, IL2RB and PDE10A were differentially expressed during human lung development. Our data provide insight about the role of asthma susceptibility genes during lung development and suggest common mechanisms underlying lung morphogenesis and pathogenesis of respiratory diseases.
Increased p130Cas activity induces smooth muscle cell proliferation and migration in idiopathic pulmonary arterial hypertension (2011)

Introduction: p130 Cas is a docking protein integrating and regulating extracellular cues and intracellular signaling pathways that controls cell proliferation and motility. Therefore, we hypothesize that p130 Cas contributes to excessive migration and proliferation of PA-SMCs in idiopathic Pulmonary Arterial Hypertension (iPAH). Methods: Protein and phosphorylation levels of p130 Cas were quantified by Western blot in surgically resected lung specimens from iPAH-patients and normal subjects. To assess the functional role of p130 Cas in iPAH and controls, we evaluated migration and proliferation of cultured PA-SMCs with and without p130 Cas inhibition by siRNA. Results: We observed significantly elevated p130 Cas protein expression and activity in iPAH-patients compared to controls. In addition, decreasing p130 Cas signaling by RNA-interference reduced to similar levels both the migration and proliferative potentials of IPAH and control PA-SMCs. The decreased migration and proliferation are respectively mediated by decreased matrix metalloproteinase (MMP)-2 release and by decreased mitogen-activated protein kinase (MAPK) activation. Conclusions: These results demonstrate that p130 Cas protein expression and activity induces PA-SMC proliferation and migration in iPAH, suggesting p130 Cas as an attractive drug target for PAH therapy.
Detection of cervical intraepithelial neoplasia using impedance spectroscopy: a prospective study (2005)

Cervical impedance spectrometry provides a potentially promising screening tool with similar sensitivity and specificity to currently used screening tests, but with the potential advantage of providing instant results. Further work is currently being undertaken to improve the probe in its clinical use.
Gender differences in reaching top roles in banking: a cross-sectional study performed by bankers work in province of Pisa (2022)

&#x0D; The financial industry is a pivot of the economy and plays an important social role.&#x0D; Goal of this study was to analyze factors associated with the framing level in banking in the province of Pisa.&#x0D; We collected data about age, gender, framing level, workplace and type of bank for bankers in Pisa through trade unionists.&#x0D; We collected data on 2018 workers and we found significant associations between framing level and aged over 40 years (OR = 4.5; 95% CI: 2.9-6.9), workplace in Pisa (OR = 0.30; 95% CI: 0.20-0.44) and male gender (OR = 2.89; 95% CI: 1.98-4.21).&#x0D; The first two factors are explainable with organizational characteristics. In fact for becoming manager you already have to work a number of year and in cities rather than in the surrounding municipalities, consistent with the size of bank.&#x0D; However, the third factor, already known in the literature in other work areas, requires further studies for explaining causes and helping to implement actions to reduce the gender gap.&#x0D;
Evolution of the mammalian dentate gyrus (2015)

The dentate gyrus (DG), a part of the hippocampal formation, has important functions in learning, memory, and adult neurogenesis. Compared with homologous areas in sauropsids (birds and reptiles), the mammalian DG is larger and exhibits qualitatively different phenotypes: 1) folded (C- or V-shaped) granule neuron layer, concave toward the hilus and delimited by a hippocampal fissure; 2) nonperiventricular adult neurogenesis; and 3) prolonged ontogeny, involving extensive abventricular (basal) migration and proliferation of neural stem and progenitor cells (NSPCs). Although gaps remain, available data indicate that these DG traits are present in all orders of mammals, including monotremes and marsupials. The exception is Cetacea (whales, dolphins, and porpoises), in which DG size, convolution, and adult neurogenesis have undergone evolutionary regression. Parsimony suggests that increased growth and convolution of the DG arose in stem mammals concurrently with nonperiventricular adult hippocampal neurogenesis and basal migration of NSPCs during development. These traits could all result from an evolutionary change that enhanced radial migration of NSPCs out of the periventricular zones, possibly by epithelial-mesenchymal transition, to colonize and maintain nonperiventricular proliferative niches. In turn, increased NSPC migration and clonal expansion might be a consequence of growth in the cortical hem (medial patterning center), which produces morphogens such as Wnt3a, generates Cajal-Retzius neurons, and is regulated by Lhx2. Finally, correlations between DG convolution and neocortical gyrification (or capacity for gyrification) suggest that enhanced abventricular migration and proliferation of NSPCs played a transformative role in growth and folding of neocortex as well as archicortex.
A Simple Theory for the Hofmeister Series (2013)

In cells, biological molecules function in an aqueous solution. Electrolytes and other small molecules play important roles in keeping the osmotic pressure of the cellular environment as well as the structure formation and function of biomolecules. The observed empirical rules such as Hofmeister series are still waiting for molecular interpretations. In this Perspective, we will discuss a simple and self-consistent theory that takes into account the cooperative effects of cations and anions in affecting water/air surface tension, water activity, and the solubility of model compounds including polypeptides. Molecular dynamics simulations used to test these theoretical models will also be discussed.
All Solid State Lithium–Sulfur Battery Using a Glass-Type P2S5–Li2s Electrolyte (2014)

Introduction Lithium-sulfur battery has attracted great attention since its electrochemical process, i.e. 16Li + S8 = 8Li2S, theoretically provides a specific energy of 2500 Wh Kg -1 much larger than the 650 Wh Kg -1 of the conventional lithium battery presently offered by the market and largely used in the electronic devices. However, to realize the practical battery based on the sulfur cathode, its red-ox shuttle of polysulfide originated in the dissolution into the organic electrolyte is strongly required to prevent for improving the charge/discharge cycle ability. On the contrary, solid state sulfide electrolytes are of considerable practical concern in these days. Application of a solid-state ion conductor is one of promising candidates for avoiding the red-ox shuttle due to the dissolution of polysulfide in Li-S battery. Its applicability of Li 2 S-P 2 S 5 based solid electrolyte to the sulfur cathode has been reported using Li-In alloy for the anode 1) . To obtain higher energy density, we adopted pure Li and verified its applicability to the all solid-state Li-S battery. Experimental A solid state lithium ion conductor was prepared by using high energy ball milling method. Li2S:P2S5=80:20 mol% (SE) was adopted. A coin cell, 2032 was prepared by stacking and compressing Li foil, SE, and sulfur/MCMB(50:50wt%) mixture. The loading level of net sulfur was approximately 0.9mgcm -2 . Another cell configuration, a compression metal cell was also used for verifying the electrochemical performances. The electrochemical measurements were mostly performed at 80 o C. The details are given in our previous paper 2) . Results and Discussion The Li/Li2S–P2S5/S-MCMB cell was prepared and its electrochemical characteristics were evaluated by Galvanostatic charge discharge cycle at 80 °C. The average discharge potential was approximately 2.1 V and a cycling capacity of 400 mAh g −1 at a C/20 rate was observed. The cycling tests show ca.100% Coulombic efficiency and stable capacity. However, only 25% of the theoretical capacity of the sulfur electrode was obtained in this system, because of the high resistance of the solid–solid interface at the cathode side and the associated ohmic polarization during cycling. Nevertheless, the very stable capacity of 400 mAh g −1 at a working voltage of 2.1 V results in a theoretical energy density of 840 Wh kg −1 , In addition, the solid cell here reported is characterized by very high safety level, since the cell is completely based on solid-state. The details of the electrochemical characteristics on anode and cathode including recent progress are given in the poster. 1) M. Nagao, A. Hayashi, M. Tatsumisago, J. Mater. Chem. 22 (2012) 10015–10020 2) M. Agostini, Y. Aihara, T. Yamada, B. Scrosati, J. Hassoun, Solid State Ionics 244 (2013) 48–51
Batatasin III a derivative of dihydrostilbene compound from Yam Peel of Uwi Tuban and Its Antioxidant Activity (2018)

A dihydrostilbene derivative compound, namely 3,3-dihydroxy-5-methoxybibenzyl or batatasin III (1) was isolated from the yam peel of Dioscorea alata L. The structure of compound 1 has been elucidated based on spectroscopy UV-Vis, 1D and 2D NMR Analysis. The IC50 of DPPH radical scavenging of this compound (206.82 μg/mL) lower than ethyl acetate extract (109.99 μg/mL), but higher than methanol extract (893.59 μg/mL).
An Efficient Content-Addressable Memory Implementation Using Dynamic Routing (2001)

Content addressable memories are important components in high-speed networking equipment. This paper describes the design of a wide CAM suitable for use as an IPv6 traffic classifier for a 622Mb/s communications link. The design flow uses a combination of standard design tools in conjunction with JBits, a low-level configuration API for manipulating programmable resources. The CAMs are 320 bits wide to accommodate a full IPv6 header. The most powerful wildcarding possible is supported, ranging from dont cares on single bits of the header, all the way through to dont cares for the whole header. A priority mechanism has been designed which allows explicit priority encoding to be used without required a costly sorting network. This is performed by dynamic routing, whereby routes are determined at run-time between the match units and the priority encoder. This allows a smaller, faster implicit priority encoder to be used, whilst still allowing priority to be explicitly defined. An experimental set-up is shown, which allows 128 320-bit patterns to be matched at 50.9 Msearches/s.
Delayed Tooth Eruption in Membrane Type-1 Matrix Metalloproteinase Deficient Mice (2003)

Membrane-type 1 matrix metalloproteinase (MT1-MMP) is expressed highly in mineralizing tissues including bones and teeth. Mice deficient in MT1-MMP (-/-) display severe defects in skeletal development including dwarfism, osteopenia, and craniofacial abnormalities. Death occurs in these mice by about 3 weeks of age. Since MT1-MMP is expressed by the ameloblasts of the enamel organ and by the odontoblasts of the dental papilla, we asked if the developing teeth were adversely affected in the knockout animals. Molars from MT1-MMP -/- mice and controls were examined by histological, X-ray, and SEM analysis at 4, 18-20, and 25 days of postnatal development. At 4 days of development the molars from the -/- mice appeared histologically normal. At 18-20 days of development, the first molars of the -/- mice had apparently normal tooth crowns with normal dentin and enamel; however, the roots were truncated and the teeth had not yet erupted. In contrast to the -/- mice, the first molars of the 18-20-day control animals had erupted. SEM analysis of a -/- first molar and incisor revealed a normal enamel prism pattern. However, X-ray analysis demonstrated that tooth eruption was delayed by approximately 5 days and that the tooth roots were abnormally short in the knockout animals. Since MT1-MMP-deficient mice have been demonstrated to display a generalized increase in bone resorption, these data suggest that inefficient growth of bone surrounding the tooth root complex causes a delay in tooth eruption.