gebhart/patrepeval huggingface dataset:
Structure of liquid water at high pressures and temperatures (2002)

We report quantitatively accurate structure-factor and radial-distribution-function measurements of liquid water in a diamond-anvil cell (DAC) using x-ray diffraction. During the analysis of our diffraction data, we found it possible (and necessary) to also determine the density. Thus, we believe we present the first-ever diffraction-based determination of a liquid structure factor and equation of state in a DAC experiment.
Adaptive Information Filtering: Learning in the Presence of Concept Drifts (1998)

The task of information ltering is to classify texts from a stream of documents into relevant and nonrelevant, respectively, with respect to a particular category or user interest, which maychange over time. A ltering system should be able to adapt to such concept changes. This paper explores methods to recognize concept changes and to maintain windows on the training data, whose size is either xed or automatically adapted to the current extent of concept change. Experiments with two simulated concept drift scenarios based on real-world text data and eight learning methods are performed to evaluate three indicators for concept changes and to compare approaches with xed and adjustable window sizes, respectively, to each other and to learning on all previously seen examples. Even using only a simple window on the data already improves the performance of the classi ers signi cantly as compared to learning on all examples. For most of the classi ers, the window adjustments lead to a further increase in performance compared to windows of xed size. The chosen indicators allow to reliably recognize concept changes.
System-Level Analysis of MPSoCs with a Hardware Scheduler (2016)

Efficient runtime resource management in heterogeneous Multi-Processor Systems-on-Chip (MPSoCs) for achieving high performance and energy efficiency is one key challenge for system designers. In the past years, several IP blocks have been proposed that implement system-wide runtime task and resource management. As the processor count continues to increase, it is important to analyze the scalability of runtime managers at the system-level for different communication architectures. In this chapter, the authors analyze the scalability of an Application-Specific Instruction-Set Processor (ASIP) for runtime management called OSIP on two platform paradigms: shared and distributed memory. For the former, a generic bus is used as interconnect. For distributed memory, a Network-on-Chip (NoC) is used. The effects of OSIP and the communication architecture are jointly investigated from the system point of view, based on a broad case study with real applications (an H.264 video decoder and a digital receiver for wireless communications) and a synthetic benchmark application.
Alternative Splicing in the Aggrecan G3 Domain Influences Binding Interactions with Tenascin-C and Other Extracellular Matrix Proteins (2004)

The proteoglycans aggrecan, versican, neurocan, and brevican bind hyaluronan through their N-terminal G1 domains, and other extracellular matrix proteins through the C-type lectin repeat in their C-terminal G3 domains. Here we identify tenascin-C as a ligand for the lectins of all these proteoglycans and map the binding site on the tenascin molecule to fibronectin type III repeats, which corresponds to the proteoglycan lectin-binding site on tenascin-R. In the G3 domain, the C-type lectin is flanked by epidermal growth factor (EGF) repeats and a complement regulatory protein-like motif. In aggrecan, these are subject to alternative splicing. To investigate if these flanking modules affect the C-type lectin ligand interactions, we produced recombinant proteins corresponding to aggrecan G3 splice variants. The G3 variant proteins containing the C-type lectin showed different affinities for various ligands, including tenascin-C, tenascin-R, fibulin-1, and fibulin-2. The presence of an EGF motif enhanced the affinity of interaction, and in particular the splice variant containing both EGF motifs had significantly higher affinity for ligands, such as tenascin-R and fibulin-2. The mRNA for this splice variant was shown by reverse transcriptase-PCR to be expressed in human chondrocytes. Our findings suggest that alternative splicing in the aggrecan G3 domain may be a mechanism for modulating interactions and extracellular matrix assembly.
Blind separation of nonstationary and temporally correlated sources from noisy mixtures (2002)

We present a new method of blind source separation that is robust with respect to additive white noise. Our method exploits the nonstationarity and temporal structure of sources. The method needs only multiple time-delayed correlation matrices of the observation data at several different time-windowed frames to estimate the mixing matrix. We present an implementation based on the joint diagonalization. Extensive simulations verify the high performance of the proposed method, especially in a low SNR environment.
Association of lipoprotein-associated phospholipase A2 levels with coronary artery disease risk factors, angiographic coronary artery disease, and major adverse events at follow-up (2004)

Higher Lp-PLA2 levels were associated with a higher incidence of major adverse events at follow-up, independently of traditional CAD risk factors and C-reactive protein.
Ostia. Temple de Sérapis (III, XVII, 4) (2019)

Le temple de Sérapis, exhumé en 1939, se situe au nord-ouest de la ville, dans une zone trapézoïdale comprise entre des horrea à l’ouest, la Via della Foce au nord et la Via degli Aurighi au sud. Il fait partie d’un vaste ensemble édilitaire, ordonné autour d’un axe central, la Via del Serapide, qui a été édifié entre 124 et 127 (fig. 6, n° 9 ; fig. 183). L’identification du temple est assurée par les inscriptions retrouvées dans la cour à portique qui le précède (voir infra). Le sanctuaire a...
Three‐repeat and four‐repeat tau isoforms form different oligomers (2021)

Different tauopathies are characterized by the isoform-specific composition of the aggregates found in the brain and by structurally distinct tau strains. Although tau oligomers have been implicated as important neurotoxic species, little is known about how the primary structures of the six human tau isoforms affect tau oligomerization because the oligomers are metastable and difficult to analyze. To address this knowledge gap, here, we analyzed the initial oligomers formed by the six tau isoforms in the absence of posttranslational modifications or other manipulations using dot blots probed by an oligomer-specific antibody, native-PAGE/western blots, photo-induced cross-linking of unmodified proteins, mass-spectrometry, and ion-mobility spectroscopy. We found that under these conditions, three-repeat (3R) isoforms are more prone than four-repeat (4R) isoforms to form oligomers. We also tested whether known inhibitors of tau aggregation affect its oligomerization using three small molecules representing different classes of tau aggregation inhibitors, Methylene Blue (MB), the molecular tweezer CLR01, and the all-D peptide TLKIVW, for their ability to inhibit or modulate the oligomerization of the six tau isoforms. Unlike their reported inhibitory effect on tau fibrillation, the inhibitors had little or no effect on the initial oligomerization. Our study provides novel insight into the primary-quaternary structure relationship of human tau and suggests that 3R-tau oligomers may be an important target for future development of compounds targeting pathological tau assemblies.
Supplementary Table S4: from Cancer Therapy Directed by Comprehensive Genomic Profiling: A Single Center Study (2023)

&lt;p&gt;Comparison of TTF1 between groups&lt;/p&gt;
Development of A UHPLC–MS/MS (SRM) Method for The Quantitation of Endogenous Glucagon and Dosed Glp-1 from Human Plasma (2017)

The LC-MS/MS method offers a viable alternative to immunoassays for quantitation of endogenous glucagon, dosed glucagon and/or dosed GLP-1.
A statistical model describing combined irreversible electroporation and electroporation-induced blood-brain barrier disruption (2016)

The statistical model can be used to describe the dependence of treatment-effects on the number of pulses independent of the experimental setup.
Guidelines for 1D-periodic surface microstructures for antireflective lenses (2010)

Antireflective properties of one-dimensional periodically microstructured lens surfaces (refractive index 1.5) are studied with the Green's function surface integral equation method, and design guidelines are obtained. Special attention is given to the requirement of having practically all incident light transmitted in the fundamental transmission diffraction order. The effect of the presence of higher transmission diffraction orders is studied to determine if such more easily fabricated structures will be useful. The decrease of optimum fill factor of a periodic array of subwavelength ridges with structure period is explained as a waveguiding effect. Near-fields are calculated illustrating standing-wave interference and waveguiding effects for ridge structures, and adiabatic field transformation for tapered structures, including evanescent near-fields in in- and out-coupling regions. The antireflective properties of tapered geometries are considered for a wide range of angles of light incidence. It is found that while the reflection can be very small this rarely implies high transmission into the fundamental transmission diffraction order when higher-order transmission diffraction orders exist. This leads to the guideline that for visible and normally incident light the surface structure period should not be larger than ~300 nm, and a smaller period is needed in the case of oblique light incidence.
Joint ACCP/AACVPR Evidence-Based Clinical Practice Guidelines (2007)

Background: Pulmonary rehabilitation has become a standard of care for patients with chronic lung diseases. This document provides a systematic, evidence-based review of the pulmonary rehabilitation literature that updates the 1997 guidelines published by the American College of Chest Physicians (ACCP) and the American Association of Cardiovascular and Pulmonary Rehabilitation. Methods: The guideline panel reviewed evidence tables, which were prepared by the ACCP Clinical Research Analyst, that were based on a systematic review of published literature from 1996 to 2004. This guideline updates the previous recommendations and also examines new areas of research relevant to pulmonary rehabilitation. Recommendations were developed by consensus and rated according to the ACCP guideline grading system. Results: The new evidence strengthens the previous recommendations supporting the benefits of lower and upper extremity exercise training and improvements in dyspnea and health-related quality-of-life outcomes of pulmonary rehabilitation. Additional evidence supports improvements in health-care utilization and psychosocial outcomes. There are few additional data about survival. Some new evidence indicates that longer term rehabilitation, maintenance strategies following rehabilitation, and the incorporation of education and strength training in pulmonary rehabilitation are beneficial. Current evidence does not support the routine use of inspiratory muscle training, anabolic drugs, or nutritional supplementation in pulmonary rehabilitation. Evidence does support the use of supplemental oxygen therapy for patients with severe hypoxemia at rest or with exercise. Noninvasive ventilation may be helpful for selected patients with advanced COPD. Finally, pulmonary rehabilitation appears to benefit patients with chronic lung diseases other than COPD. Conclusions: There is substantial new evidence that pulmonary rehabilitation is beneficial for patients with COPD and other chronic lung diseases. Several areas of research provide opportunities for future research that can advance the field and make rehabilitative treatment available to many more eligible patients in need. (CHEST 2007; 131:4S–42S)
Low affinity binding of mouse immunoglobulin to human CD5+ B cells (1991)

Polyreactive immunoglobulin (Ig) secreted by CD5-bearing B cells has the capacity to bind a broad range of self and foreign antigens. Flow cytometric analysis was used to detect low-affinity binding of mouse Ig molecules to the surface of CD5-bearing B cells from patients with chronic lymphocytic leukaemia (CLL). Mouse Ig isotypes G, A, and M, and IgG subclasses G1, G2a, and G3 bound to the B cell surface via a mechanism not involving the antigen-binding site of the mouse Ig molecule. Fab and F(ab')2 fragments of mouse Ig associated with the CLL cells in a similar manner to intact Ig, indicating that Fc receptor interactions were not involved. Dissociation of the mouse Ig from the B cell surface by three washing steps distinguished this lower-affinity binding from high-affinity binding which occurs through the antigen-binding site of a mouse monoclonal antibody (MoAb) when it recognizes a specific cell surface epitope. Blocking studies suggest that the low-affinity binding occurred via surface IgM and surface IgD (sIgM/sIgD) on the CD5-bearing B cells. The results are consistent with the expression of polyreactive Ig on the surface of CD5-bearing B cells in CLL.
TrkB (Tropomyosin-Related Kinase B) Controls the Assembly and Maintenance of GABAergic Synapses in the Cerebellar Cortex (2011)

Inhibitory interneurons play a critical role in coordinating the activity of neural circuits. To explore the mechanisms that direct the organization of inhibitory circuits, we analyzed the involvement of tropomyosin-related kinase B (TrkB) in the assembly and maintenance of GABAergic inhibitory synapses between Golgi and granule cells in the mouse cerebellar cortex. We show that TrkB acts directly within each cell-type to regulate synaptic differentiation. TrkB is required not only for assembly, but also maintenance of these synapses and acts, primarily, by regulating the localization of synaptic constituents. Postsynaptically, TrkB controls the localization of a scaffolding protein, gephyrin, but acts at a step subsequent to the localization of a cell adhesion molecule, Neuroligin-2. Importantly, TrkB is required for the localization of an Ig superfamily cell adhesion molecule, Contactin-1, in Golgi and granule cells and the absence of Contactin-1 also results in deficits in inhibitory synaptic development. Thus, our findings demonstrate that TrkB controls the assembly and maintenance of GABAergic synapses and suggest that TrkB functions, in part, through promoting synaptic adhesion.
Occlusion Robust Light Field Depth Estimation Using Segmentation Guided Bilateral Filtering (2017)

Although light field data provides abundant cues for depth estimation, light field depth estimation suffers from occlusion and uncertain edges. In this paper, we propose occlusion robust light field depth estimation using segmentation guided bilateral filtering. First, we calculate refocused images from light field data using digital refocusing. Second, we perform support vector machines (SVM) classification to classify occluded pixels and non-occluded pixels. Third, we conduct different cost estimations on occluded and non-occluded pixels, and remove noise by cost volume filtering. Finally, we perform segmentation-guided bilateral filtering to refine the depth map while preserving edges. Experimental results on both synthetic and our own data sets demonstrate that the proposed method achieves light field depth estimation robust to occlusion while successfully preserving edges.
Patterned Staining by Fluorescein-Labeled Oligonucleotides Obtained by in Vitro Selection (1996)

We describe a new means of surface staining using a fluorescent oligonucleotide. A folic acid-specific, fluorescent-labeled oligonucleotide was selected from a group of randomly sequenced oligonucleotides by repeated elution through a folic acid-immobilized column and amplified by the polymerase chain reaction. We then examined the oligonucleotide scattered on a polyester film with folic acid immobilized in a defined pattern, by means of laser fluorescence microscopy. The results showed that the selected oligonucleotide fluoresced exactly following the pattern of immobilized folic acid.
Programação de tripulantes de aeronaves no contexto brasileiro. (2009)

This master of science research treats the Crew Scheduling Problem (CSP), as part of the airlines operational planning. The main aim of the CSP is to assign a set of tasks to crew members, considering the labor regulations, safety rules and policies of companies, such that the crew cost is minimal.
Deep neural network accelerator based on FPGA (2017)

In this work, we propose an efficient architecture for the hardware realization of deep neural networks on reconfigurable computing platforms like FPGA. The proposed neural network architecture employs only one single physical computing layer to perform the whole computational fabric of fully-connected feedforward deep neural networks with customizable number of layers, number of neurons per layer and number of inputs. The inputs, weights and outputs of the network are represented in 16-bit half-precision floating-point number format. The network weights are hard-coded using on-chip memory of FPGA devices, allowing for very fast computation. For performance evaluation, the handwritten digit recognition application with MNIST database is performed, which reported a recognition rate of 97.20% and a peak performance of 15.81 kFPS when using a deep neural network of size 784-40-40-10 on the Xilinx Virtex-5 XC5VLX-110T device. When implementing a deep neural network of size 784-126-126-10 for MNIST database on the Xilinx ZynQ-7000 XC7Z045 device, the recognition rate is 98.16% and the peak performance is 15.90 kFPS.
ChemInform Abstract: Oxidative Cleavage of Methyl Ethers Using the HOF×CH3CN Complex. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Arrhythmogenic Remodeling of the Left Ventricle in a Porcine Model of Repaired Tetralogy of Fallot (2018)

We found an arrhythmogenic substrate with prolonged heterogeneous action potential duration and reduced conduction velocity in the LV of rTOF pigs. This remodeling precedes LV dysfunction and is likely to contribute to ventricular arrhythmias and sudden cardiac death in patients with rTOF.
Analytical modeling of mutually coupled switched reluctance machines under saturation based on design geometry (2015)

An analytical model of the winding flux linkage is proposed for fully pitched mutual coupled switched reluctance motors (MCSRM). Basic magnetic field laws are used for the derivation phase winding fluxes of the machine. The model is not empirical and does not require any finite element analysis (FEA) data. The model only takes in the dimensions of the machine as inputs and then calculates the winding flux linkage at any current and rotor position. The model is applicable for the rotor positions where the stator and rotor poles overlap. There are some assumptions which are described initially. Then the step by step procedure of flux linkage calculation is provided. The flux linkages predicted through the model is compared with the FEA results.
Bayesian reservoir characterization (2002)

This research aims to provide a complete solution for reservoir properties determination, including estimation and uncertainty analysis. The strengths of this reservoir characterization methodology is: i) uncertainty analysis and ii) integration of multiple geophysical data-sets, rock physics analysis and prior information in a straightforward way provided by the Bayesian framework. The inference problem reported on this paper is formulated to solve the problem of porosity estimation. The sources of information are pre-stack seismic data; well log data and core samples. The reservoir is considered a volume composed of cells. The final solution is a probability density function (pdf) for porosity for each cell of the reservoir volume. These pdfs, call posterior pdfs, represent deductions about porosity and incorporate all related uncertainties. The waveform elastic inversion is incorporated in this methodology to access the porous medium physical property information from pre-stack seismic data. Geostatistical modelling is incorporated to access the porous medium spatial variability information from well-log data. The methodology is implemented to consider a reservoir composed for block cells. One posterior pdf is computed for each reservoir cell. Two cell volumes present the final result. One is constructed with the modes of the posterior pdfs related to each cell and represents the estimated porosity model, and the other is constructed with the confidence interval of the posteriors pdfs and represents a measure of the related uncertainties.
Salpingoscopy: Light microscopic and electron microscopic correlations (1992)

In order to examine the ability of salpingoscopy to diagnose intratubal pathology, 32 fallopian tubes were evaluated salpingoscopically and histologically. Both flexible and rigid salpingoscopes were used, and observations were documented by intratubal photography. Salpingoscopic criteria were established and each criterion assigned a numerical value. Each tube was evaluated for patency, mucosal fold architecture, erythema, adhesions, and dilatation. Based on these criteria, tubes were graded as normal or as abnormal with mild, moderate, or severe changes. Histologically, each tube was evaluated for patency, epithelial changes, vascularity, dilatation, adhesions, and active inflammation. Six tubes with significant histologic findings and two histologically normal fallopian tubes were also examined by transmission electron microscopy. In five discordant cases, histology revealed epithelial and stromal changes not detected by salpingoscopy. Fallopian tubes with severe disease were diagnosed by both methods. Transmission electron microscopy of histologically abnormal tubes showed flattening of the epithelium with markedly reduced ciliary distribution, degenerating secretory epithelial cells with large intracellular vacuoles, and swollen nuclei containing sparse chromatin. Our results indicate that salpingoscopic observations are consistent with histologic findings when endotubal disease is severe. However, moderate pathologic changes as documented by light microscopy and transmission electron microscopy were frequently not diagnosed salpingoscopically, even with magnification.
A New Coordination Mode for the Tripodal [Te(NtBu)3]2− Dianion: Preparation and Structures of {ClIn[Te(NtBu)3]}2 and {LiIn[Te(NtBu)3]2}·LiCl (2002)

The complexes {ClIn[Te(NtBu)3]}2 (1) and {LiIn[Te(NtBu)3]2}· LiCl (2) are formed from the reaction of InCl3 (or InCl) with {Li2[Te(NtBu)3]}2 in toluene. The [Te(NtBu)3]2− dianions in the centrosymmetric dimer 1 act as tridentate [bis(N,N′-monodentate), μ2-N′′] ligands bridging two indium atoms. Complex 2 involves a spirocyclic indium centre bis(N,N′-chelated) by two [Te(NtBu)3]2− ions. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)