gebhart/patrepeval huggingface dataset:
Permeability profiling of all 13 Arabidopsis PIP aquaporins using a high throughput yeast approach (2021)

Abstract Plant aquaporins have many more functions than just transporting water. Within the diversity of plant aquaporins are isoforms capable of transporting signaling molecules, nutrients, metalloids and gases. It is established that aquaporin substrate discrimination depends on combinations of factors such as solute size, pore size and polarity, and post-translational protein modifications. But our understanding of the relationships between variation in aquaporin structures and the implications for permeability is limited. High-throughput yeast-based assays were developed to assess diverse substrate permeabilities to water, H 2 O 2 , boric acid, urea and Na + . All 13 plasma membrane intrinsic proteins (PIPs) from Arabidopsis (AtPIPs) were permeable to both water and H 2 O 2 , although their effectiveness varied, and none were permeable to urea. AtPIP2 isoforms were more permeable to water than AtPIP1s, while AtPIP1s were more efficient at transporting H 2 O 2 with AtPIP1;3 and AtPIP1;4 being the most permeable. Among the AtPIP2s, AtPIP2;2 and AtPIP2;7 were also permeable to boric acid and Na + . Linking AtPIP substrate profiles with phylogenetics and gene expression data enabled us to align substrate preferences with known biological roles of AtPIPs and importantly guide towards unidentified roles hidden by functional redundancy at key developmental stages and within tissue types. This analysis positions us to more strategically test in planta physiological roles of AtPIPs in order to unravel their complex contributions to the transport of important substrates, and secondly, to resolve links between aquaporin protein structure, substrate discrimination, and transport efficiency. One sentence summary Yeast based high throughput assays were developed to assess the permeability of each Arabidopsis PIP aquaporin isoform to water, H 2 O 2 , boric acid, urea and sodium.
JavaScript & DHTML Cookbook (2003)

On numerous online forums for JavaScript and DHTML, the majority of questions begin with How do I...? This new Cookbook provides the answers with a comprehensive collection of problems, solutions, and practical examples. The book's recipes range from simple tasks, such as manipulating strings and validating dates in JavaScript, to entire libraries that demonstrate complex tasks, such as cross-browser positioning of HTML elements and sorting tables.
Estimation of the flux linkage in a direct-torque-controlled drive (2003)

An improved integration method is presented for the estimation of the stator flux linkage for speed- and position-sensorless direct-torque-controlled AC machine drives. The method is based on monitoring the scalar product of the estimated stator flux linkage and the measured stator current. The AC part of the scalar product is extracted using filtering and the correction for the estimated stator flux linkage is formed from that part. Adequate performance is obtained by using simple low-pass filtering. By using adaptive filtering in the extraction, the performance of the drive is excellent. Both simulation and laboratory test results are presented, which show that the presented method works well both in steady state and in transients.
Improved photoenergy properties of low-emissivity coatings deposited by sputtering with an ion gun treatment (2022)

This work studies the effect of ion treatment on low-emissivity (low-e) coatings deposited by magnetron sputtering. Specifically, we have investigated the application of an ion treatment in the dielectric layer before deposition of a layer of silver. This reduces layer roughness which means the silver layer can be deposited with enhanced characteristics. We have also evaluated the etching rate on the SnOx layer due to the ion treatment on already deposit coatings of equal thicknesses. Subsequently, we studied the effects on the coating's photoenergy properties. For equivalent coatings, we found that those treated with ions were more transparent in the visible region, more reflective, and had a lower emissivity, which are essential requirements for low-e coatings applied in architectural glass.
553-P: Differential Effects of High-Intensity Interval Training on Somatosensory and Autonomic Nerve Function in Patients with Type 2 Diabetes (2019)

It remains unclear, whether exercise training as part of lifestyle intervention has favorable effects on the development or progression of diabetic neuropathy in patients with type 2 diabetes (T2D). Therefore, we assessed peripheral and autonomic nerve fiber function and morphology in patients with T2D as well as in individuals with normal glucose tolerance (CON) before and after a high intensity interval training (HIIT) intervention program over 12 weeks. The T2D group included 20 male individuals ([median (1st; 3rd quartile)] age: 56 (53; 63) years; diabetes duration: 5 (2; 9) years; BMI: 31.2 (28.6; 32.8) kg/m²; HbA1c: 6.9 (6.4; 8.0)%). The CON group was matched for age, sex, and BMI (n=23; age: 57 (53; 60) years; BMI: 30.3 (28.4; 32.2) kg/m²; HbA1c: 5.4 (5.2; 5.7)). Somatosensory and autonomic nerve tests included nerve conduction velocity, quantitative sensory testing, skin biopsy, corneal confocal microscopy, cardiovascular autonomic function tests (CAFT), and spontaneous baroreflex sensitivity (BRS). After 12 weeks of HIIT, no improvement in somatosensory nerve tests was detected in T2D or CON. In both groups, resting heart rate decreased ([mean±SEM] baseline vs. follow-up: T2D: 68.8±2.3 vs. 63.4±1.8 bpm; CON: 65.1±1.8 vs. 60.2±1.9 bpm; both P&amp;lt;0.05). The change in systolic blood pressure after standing up (-13.9±2.6 vs. -9.4±2.2 mmHg) and three BRS sequence analysis indices (e.g., BRS-slope: 7.9±1.9 vs. 12.6±5.1 ms/mmHg) improved in T2D (P&amp;lt;0.05), while the standard deviation of normal RR intervals (SDNN; 36.1±2.6 vs. 55.3±8.8 ms; P&amp;lt;0.05) and coefficient of variation (CV; 3.8±0.3 vs. 5.2±0.7%; P&amp;lt;0.05) improved in CON. In conclusion, while cardiovascular autonomic function improved moderately after 12 weeks of HIIT in male T2D patients, a longer training period may be required to achieve favorable effects on somatosensory nerve function or morphology. Disclosure G.J. Bönhof: None. A. Strom: None. M. Apostolopoulou: None. D. Pesta: None. M. Roden: Advisory Panel; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Poxel SA, Servier. Board Member; Self; Eli Lilly and Company. Research Support; Self; Boehringer Ingelheim Pharmaceuticals, Inc., Sanofi. Speaker's Bureau; Self; Novo Nordisk Inc. D. Ziegler: Advisory Panel; Self; Allergan, TrigoCare. Consultant; Self; Mitsubishi Tanabe Pharma Corporation, Mylan, Novartis Pharmaceuticals Corporation, Wörwag. Speaker's Bureau; Self; Berlin-Chemie AG. Funding German Ministry of Culture and Science of the State of North Rhine-Westphalia; German Federal Ministry of Health; German Federal Ministry of Education and Research
Graph Based Scalable Algorithms with Applications (2014)

The bioavailability of propranolol from a matrix-in-cylinder system for sustained drug delivery, consisting of a hot-melt extruded ethylcellulose pipe surrounding a drug-containing HPMC-Gelucire 44/14 core, was determined. An oral dose of 80 mg propranolol hydrochloride was administered to healthy volunteers (n = 10) in a randomized cross-over study design either as a commercial pellet formulation (Inderal retard mitis) or as a matrix-in-cylinder system. The influence of concomitant food intake on drug release from the matrix-in-cylinder system was also studied. During the first 10 h after administration, the matrix-in-cylinder system resulted in similar plasma levels as the reference formulation Inderal. The concomitant intake of a high-fat, high-calorie breakfast did not cause dose-dumping. Between 10 h and 24 h after administration of the matrix-in-cylinder system, a remarkable increase of the propranolol plasma levels was noticed (compared to Inderal). This effect was even more pronounced under fed conditions. The matrix-in-cylinder system had a relative bioavailability of 156% (fasted conditions) and 222% (fed conditions) compared to the marketed reference product. In order to elucidate the origin of this increased bioavailability, Caco-2 experiments and dog lymph studies were performed. However, none of these experiments was able to provide a conclusive answer.
Die Charakterisierung stochastischer und deterministisch chaotischer Signaleigenschaften von Herzfrequenzvariabilität und Atmung (1994)

Article Die Charakterisierung stochastischer und deterministisch chaotischer Signaleigenschaften von Herzfrequenzvariabilität und Atmung was published on January 1, 1994 in the journal Biomedical Engineering / Biomedizinische Technik (volume 39, issue s1).
[Absence attacks with secondary bilateral synchrony]. (1992)

Three cases with petit mal absence attacks with secondary bilateral synchrony were presented. The interictal EEG showed unilateral focal epileptic discharges in the frontal area with normal background activity. The ictal EEG disclosed 3-Hz generalized symmetrical spike-wave patterns preceded by unilateral focal discharges, which were elicited by hyperventilation. None of the three cases had abnormal neurological findings or abnormal CT findings. All three cases had normal psychomotor development. One case had a history of febrile convulsions. The ictal manifestations were as follows; impairement of consciousness without any other signs in one case, with decreased posture tone in the second, and automatism in the third. The authors suggest that there can be petit mal absence with 3-Hz generalized spike-wave discharges induced by secondary bilateral synchrony.
RF-Sputtered Bi-Substituted Iron Garnet Composite Films for Visible-Range Magnetooptics (2009)

We report on the synthesis of new magneto-optical materials with excellent optical and magneto-optical properties for visible-range and near-infrared applications. Bi-substituted composite garnet films fabricated with excess bismuth oxide content using RF co-sputtering and oven-annealing processes have been found to possess simultaneously record MO quality and uniaxial magnetic anisotropy.
Metronomics as Maintenance Treatment in Oncology: Time for Chemo-Switch (2014)

OPINION article Front. Oncol., 10 April 2014Sec. Cancer Molecular Targets and Therapeutics Volume 4 - 2014 | https://doi.org/10.3389/fonc.2014.00076
Copolymers of Pyridine Analogs of Chalcone with Butadiene (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCopolymers of Pyridine Analogs of Chalcone with ButadieneC. S. Marvel, L. F. Coleman, George P. Scott, W. K. Taft, and B. G. LabbeCite this: Ind. Eng. Chem. 1956, 48, 2, 214–218Publication Date (Print):February 1, 1956Publication History Published online1 May 2002Published inissue 1 February 1956https://pubs.acs.org/doi/10.1021/ie50554a019https://doi.org/10.1021/ie50554a019research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Myth of the Sebaceous Cyst (1964)

Arguments are presented to show that the sebaceous cyst is nonexistent. It is a variety of keratinous cyst. The cysts usually given this name are lined not by sebaceous but by keratinizing cells resembling those of the buccal mucosa. Hardened cell membranes are not formed. The fragile cells therefore break, liberating the horny contents.
New GM1 Ganglioside Derivatives for Selective Single and Double Labelling of the Natural Glycosphingolipid Skeleton (2009)

Abstract Selective single and double labelling of the natural ganglioside GM1 enables one to introduce various markers into different parts of the glycosphingolipid molecule without changing the natural skeleton. To that end, N ‐Fmoc‐2‐amino‐, N ‐Fmoc‐18‐amino‐ and S ‐(ethoxythiocarbonyl)‐18‐mercaptostearic acids have been prepared and coupled with the primary amino group in the sphingosine part of lyso‐GM1 and deAc‐deAcyl‐GM1 gangliosides. The products of these coupling reactions – building blocks 16a , 16b , 16c , 26 and 27 – may be used for the synthesis of GM1 derivatives with one or two fluorescent dye moieties or other labels of various polarities. Examples of various labelling strategies, using hydrophilic and lipophilic photostable fluorescent dyes, have been made available. The GM1 derivatives 17a , 22a and 23c labelled with the fluorescent dye ATTO 647N or the doubly labelled derivative 25b can be used as probes in fluorescence correlation spectroscopy (in conventional microscopy or stimulated emission depletion nanoscopy) to study the diffusion of lipid analogues in model or live cell membranes.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2009)
Helper Data Algorithms for PUF-Based Key Generation: Overview and Analysis (2014)

Security-critical products rely on the secrecy and integrity of their cryptographic keys. This is challenging for low-cost resource-constrained embedded devices, with an attacker having physical access to the integrated circuit (IC). Physically, unclonable functions are an emerging technology in this market. They extract bits from unavoidable IC manufacturing variations, remarkably analogous to unique human fingerprints. However, post-processing by helper data algorithms (HDAs) is indispensable to meet the stringent key requirements: reproducibility, high-entropy, and control. The novelty of this paper is threefold. We are the first to provide an in-depth and comprehensive literature overview on HDAs. Second, our analysis does expose new threats regarding helper data leakage and manipulation. Third, we identify several hiatuses/open problems in existing literature.
Using textual information from LVCSR transcripts for phonetic-based spoken term detection (2008)

This paper presents a spoken term detection method, based on automatic speech recognition and phonetic representation. The proposed method combines textual search in word transcripts obtained with a large vocabulary continuous speech recognizer system and phonetic search in the phonetization of these transcripts, to accurately locate the occurrences of a list of keywords in a broadcast corpus. Textual information from the transcripts and an efficient rescoring scheme are used to improve the performance of the phonetic search. Our experiments show that the proposed method outperforms the baseline textual and phonetic searches by its ability to separate correct detections from false alarms.
Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats (2010)

The reactive advanced glycation end product (AGE) precursor methylglyoxal (MGO) and MGO-derived AGEs are associated with diabetic vascular complications and also with an increase in oxidative stress. Glyoxalase-I (GLO-I) transgenic rats were used to explore whether overexpression of this MGO detoxifying enzyme reduces levels of AGEs and oxidative stress in a rat model of diabetes. Rats were made diabetic with streptozotocin, and after 12 weeks, plasma and multiple tissues were isolated for analysis of AGEs, carbonyl stress, and oxidative stress. GLO-I activity was significantly elevated in multiple tissues of all transgenic rats compared with wild-type (WT) littermates. Streptozotocin treatment resulted in a 5-fold increase in blood glucose concentrations irrespective of GLO-I overexpression. Levels of MGO, glyoxal, 3-deoxyglucosone, AGEs, and oxidative stress markers nitrotyrosine, malondialdehyde, and F2-isoprostane were elevated in the diabetic WT rats. In diabetic GLO-I rats, glyoxal and MGO composite scores were significantly decreased by 81%, and plasma AGEs and oxidative stress markers scores were significantly decreased by ∼50%. Hyperglycemia induced a decrease in protein levels of the mitochondrial oxidative phosphorylation complex in the gastrocnemius muscle, which was accompanied by an increase in the lipid peroxidation product 4-hydroxy-2-nonenal, and this was counteracted by GLO-I overexpression. This study shows for the first time in an in vivo model of diabetes that GLO-I overexpression reduces hyperglycemia-induced levels of carbonyl stress, AGEs, and oxidative stress. The reduction of oxidative stress by GLO-I overexpression directly demonstrates the link between glycation and oxidative stress.
The Automatist Storytelling System : putting the editor's knowledge in software (1996)

Thesis (M.S.)--Massachusetts Institute of Technology, Program in Media Arts & Sciences, 1996.
Local Search with Very Large-Scale Neighborhoods for Optimal Permutations in Machine Translation (2006)

We introduce a novel decoding procedure for statistical machine translation and other ordering tasks based on a family of Very Large-Scale Neighborhoods, some of which have previously been applied to other NP-hard permutation problems. We significantly generalize these problems by simultaneously considering three distinct sets of ordering costs. We discuss how these costs might apply to MT, and some possibilities for training them. We show how to search and sample from exponentially large neighborhoods using efficient dynamic programming algorithms that resemble statistical parsing. We also incorporate techniques from statistical parsing to improve the runtime of our search. Finally, we report results of preliminary experiments indicating that the approach holds promise. 1
On the existence of a neutral region (2012)

Consider a given space, e.g., the Euclidean plane, and its decomposition into Voronoi regions induced by given sites. It seems intuitively clear that each point in the space belongs to at least one of the regions, i.e., no neutral region can exist. As simple counterexamples show this is not true in general, but we present a simple necessary and sufficient condition ensuring the non-existence of a neutral region. We discuss a similar phenomenon concerning recent variations of Voronoi diagrams called zone diagrams, double zone diagrams, and (double) territory diagrams. These objects are defined in a somewhat implicit way and they also induce a decomposition of the space into regions. In several works it was claimed without providing a proof that some of these objects induce a decomposition in which a neutral region must exist. We show that this assertion is true in a wide class of cases but not in general. We also discuss other properties related to the neutral region, among them a one related to the concentration of measure phenomenon.
ChemInform Abstract: Asymmetric Ring Opening Reactions of Symmetrical N‐Acylaziridines with Thiols Catalyzed by Chiral Dialkyl Tartrate‐Diethylzinc Complexes. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Primary Events in Vision Probed by Ultrafast Laser Spectroscopy (1984)

This review will deal with the early events immediately following the absorption of a photon in the retina, the ultrafast optical methods that have been developed to study them and the various theoretical models that attempt to describe them.
Robust Technologies towards Automatic Speech Recognition in Car Noise Environments (2006)

This paper presents the research on robust automatic speech recognition (ASR) in car noise environments. In the front-end design, speech enhancement technologies are used to suppress the background noise in frequency domain, and then spectrum smoothing is implemented both in time and frequency index to compensate those spectrum components distorted by noise over-reduction. In acoustic model training, we propose to use an immunity learning scheme, in which pre-recorded car noises are artificially added to clean training utterances with different signal-to-noise ratios (SNR) to imitate the in-car environments. After analyzing the SNR and noise spectrum of real in-car utterances, we further refine the immunity training set by adjusting the distribution of SNR and increasing the proportion of training noises that has a similar characteristic. Evaluation results of isolated phrase recognition show that the ASR system with proposed technologies achieves the average error rate reduction (ERR) of 90.68% and 79.08% for artificial car noisy speech and real in-car speech respectively, when compared with the baseline system in which no robust technology is used
Dumbbell shaped nickel nanocrystals synthesized by a laser induced fragmentation method (2011)

Dumbbell shaped nickel nanoparticles have been synthesized for the first time by laser induced fragmentation of bulk nickel powder in aqueous sodium dodecyl sulfate. The focused output of the third harmonic from a nanosecond pulsed Nd:YAG laser operating at 35 mJ/pulse energy was used for the photo-fragmentation of micron size particles suspended in 50 mM aqueous medium. Nickel anisotropic nanocrystals have been grown by recrystallisation of nickel particles due to laser plasma generated in sodium dodecyl sulfate solution. The Vibrating Sample Magnetometer measurements of dumbbell shaped nickel nanostructure show their good ferromagnetic nature. The mechanism of the synthesis of nanostructure through melting and fragmentation has been also discussed.