gebhart/patrepeval huggingface dataset:
Fabrication of functionally graded aerogels, cellular aerogels and anisotropic ceramics (2011)

We report on the fabrication and characterization of anisotropic porous materials: functionally graded, cellular and compositionally anisotropic aerogels and ceramics. This new class of materials was fabricated by photopolymerizing selected regions of a homogeneous monolith using visible light. Visible light is not significantly absorbed and not significantly scattered by organic molecules and oxide nanoparticles in wet gels and it allows fabrication of deeply penetrating, well-resolved patterns. Simple variations of the exposure geometry allowed fabrication of a wide variety of anisotropic materials without requiring layering or bonding.
Diffusion controlled relaxation time and acceleration of velocity of sol-gel transformation for cross-linked metal alginate ionotropic gel complexes (2003)

The rate of gel-growth for spherical ionotropic metal alginate gel droplets has been studied. Experimental observations have shown that the relaxation time of the metal alginate ionotropic gel complexes of the droplet shapes decreased in the order Hg > Cd > Sn ≥ Pb-alginates, whereas the velocity of sinking under gravitational acceleration decreases in the same order. The factors which affect the relaxation time and velocity of acceleration, such as the concentration and viscosity of the alginate sol, the nature and radius of the metal ion as well as the density and pH of the electrolyte solution have been examined. The activation energies indicated that-the stability of these metal alginate gel complexes follows the order Hg > Cd > Pb ∼ Sn alginates. A mechanism consistent with the experimental results has been discussed.
Characterization of monoclonal antibodies against avian reovirus strain S1133 (1996)

Monoclonal antibodies (MAbs) were produced against a vaccinal S1133 strain of avian reovirus. Characterization of six MAbs in Western blotting, radioimmunoprecipitation and gold immunoelectron microscopy revealed that the MAbs were specific to the outer capsid proteins, mu2/mu2c, sigma2 and sigma3. Two of three MAbs, directed against sigma2 protein, neutralized the virus infectivity in a broadly specific manner, whereas the third had no neutralizing activity. The only MAb which reacted with sigma3 protein showed a type-specific neutralizing activity. Two MAbs recognizing the mu2/mu2c proteins failed to neutralize the virus infectivity.
Hypotensive Effects of The Tablets Containing "Lactotripeptides (VPP, IPP)" (2001)

In the present study, a placebo-controlled, double-blind study was conducted to investigate hypotensive effects of the daily intake of tablets containing “Lactotripeptides (Val-Pro-Pro, Ile-Pro-Pro)” chronically for 8 weeks in individuals who had mild or moderate hypertension without treatments with internal drugs (test group ; male/female = 29/13, mean 45.8±11.1 years of age, placebo group ; male/female = 30/9, mean 45.9±9.5 years of age). In the test group, SBP decreased significantly after 2 weeks and 8 weeks of treatment, by 7.4±9.6 mmHg (p<0.001) and 12.4±10.9 mmHg (p<0.001), respectively, and DBP also decreased significantly after 2 weeks and 8 weeks of treatment, by 6.7±13.2 mmHg (p<0.01) and 8.1±12.7 mmHg (p<0.001), respectively, as compared to those before the initiation of intake. In the placebo group, in contrast, no changes in blood pressure were observed during the experimental period. The decrease in SBP and DBP during the experimental period in the test group was significantly greater than in the placebo group. In addition, adverse effects such as dry cough, digestive tract symptoms or abnormal changes were not observed.
Gut Microbiota Dysbiosis Is Associated with Inflammation and Bacterial Translocation in Mice with CCl4-Induced Fibrosis (2011)

Gut microbiota alterations are associated with the development of an inflammatory environment, fibrosis progression and bacterial translocation in carbon tetrachloride-treated mice.
SCL Expression in the Mouse Embryo Detected With a Targeted lacZ Reporter Gene Demonstrates Its Localization to Hematopoietic, Vascular, and Neural Tissues (1999)

The helix-loop-helix transcription factor SCL (TAL1) is indispensable for blood cell formation in the mouse embryo. We have explored the localization and developmental potential of cells fated to express SCL during murine development using SCL-lacZ mutant mice in which the Escherichia coli lacZ reporter gene was 'knocked in' to the SCL locus. In addition to the hematopoietic defect associated with SCL deficiency, the yolk sac blood vessels in SCL(lacZ/lacZ) embryos formed an abnormal primary vascular plexus, which failed to undergo subsequent remodeling and formation of large branching vessels. Intraembryonic vasculogenesis in precirculation SCL(lacZ/lacZ) embryos appeared normal but, in embryos older than embryonic day (E) 8.5 to E9, absolute anemia leading to severe hypoxia precluded an accurate assessment of further vascular development. In heterozygous SCL(lacZ/w) embryos, lacZ was expressed in the central nervous system, vascular endothelia, and primitive and definitive hematopoietic cells in the blood, aortic wall, and fetal liver. Culture of fetal liver cells sorted for high and low levels of beta galactosidase activity from SCL(lacZ/w) heterozygous embryos indicated that there was a correlation between the level of SCL expression and the frequency of hematopoietic progenitor cells.
Levisticum officinale hairy root cultures: influence of light and light type on growth and essential oil production (2005)

The essential oils of Levisticum officinale W.D.J. Koch (Apiaceae), including those isolated from the roots, are used in the cosmetic, pharmaceutical and food industries [1]. This perennial and herbaceous plant, commonly known as lovage, is widely known by its aromatic, ornamental and medicinal properties. The effect of light and light type on growth and essential oil production of lovage hairy root cultures was studied by comparison of cultures maintained under “blue-basic” (400-550nm) and “day-light” 16h light photoperiod with control cultures maintained under darkness. All cultures were maintained in SH medium [2] and kept at 24ºC on orbital shakers at 80 r.p.m. Growth was evaluated by fresh weight (f.w.), dry weight (d.w.) and by the dissimilation method. The essential oil samples were isolated by distillation-extraction and analysed by GC and GC-MS. Control hairy root cultures showed a fifteen-fold d.w. biomass increase at the end of the growth period (six weeks), whereas an approximately eight-fold and ten-fold increase was obtained with “blue-basic” and “day-light” grown cultures, respectively. These differences were supported by morphological and histochemical analyses. Major changes were detected in the essential oil composition, but Z-falcarinol was in all cases the major oil constituent: in darkness, “day-light” and “blue-basic” grown cultures (75%, 94% and 61%, respectively).
Methods for Increasing the Efficiency of Organic Light Emitting Diodes (2010)

For ITO-free OLEDs with a high-index layer the outcoupling efficiency was increased by 300% using periodic nanostructuring. Incorporating nanoparticles between the emission layer and the cathode increased the internal quantum efficiency of ITO-OLEDs by 310%.
Overcomplete compact representation of two-particle Green's functions (2018)

Two-particle Green's functions and the vertex functions play a critical role in theoretical frameworks for describing strongly correlated electron systems. However, numerical calculations at the two-particle level often suffer from large computation time and massive memory consumption. We derive a general expansion formula for the two-particle Green's functions in terms of an overcomplete representation based on the recently proposed ``intermediate representation'' basis. The expansion formula is obtained by decomposing the spectral representation of the two-particle Green's function. We demonstrate that the expansion coefficients decay exponentially, while all high-frequency and long-tail structures in the Matsubara-frequency domain are retained. This representation therefore enables efficient treatment of two-particle quantities and opens a route to the application of modern many-body theories to realistic strongly correlated electron systems.
Figure S3 from A Phase Ib Open-Label, Dose-Escalation Study of NUC-1031 in Combination with Carboplatin for Recurrent Ovarian Cancer (2023)

&lt;p&gt;PC PVC of base PK model based on median parameters&lt;/p&gt;
Enterprise integration with ERP and EAI (2003)

Comparing internal and external approaches to enterprise business integration.
PVD-Verfahren und ihre Anwendung zur Herstellung verschleißhemmender Schichten (1982)

Article PVD-Verfahren und ihre Anwendung zur Herstellung verschleißhemmender Schichten was published on January 1, 1982 in the journal Zeitschrift für wirtschaftlichen Fabrikbetrieb (volume 77, issue 1).
Detection of vibrationally excited nitrogen by trapped electron and electron transmission methods (1981)

Two techniques for detection of vibrationally excited nitrogen using low-energy electron scattering are described. The first technique uses the trapped electron method to observe excitation from Nv2 into the B3Πg state near threshold. From the known Franck-Condon factors, the contribution from excited vibrational levels may be unfolded. The second technique employs the electron transmission method to detect sharp structure in the total scattering cross section resulting from the formation of temporary negative ions. Because of uncertainties in the total scattering cross sections from each of the vibrational levels, the transmission method is less accurate than the trapped electron technique. As a consistency check, the vibrational temperature of N2 downstream from a microwave discharge is determined as a function of the discharge power. Within their respective error limits, the two methods are in good agreement.
Emotional Creativity as a Resource of Communicative Competence of Students (2015)

Emotional creativity is considered as an internal resource of person’s activity and as a psychological means of successful interaction as the mechanism of a development origin and functioning of communicative competence. The interrelation of emotional creativity indicators and styles of communication of students is investigated. The participants of the research are 100 senior students of Moscow and Nizhny Novgorod universities. Positive connections of emotional creativity and such indicators of communicative competence as priority orientation on the achievement of main objectives of communication, abilities to understand and differentiate the experience, to distinguish emotions of partners in communication, and also to react emotionally in non-standard way in difficult communicative situations are revealed. Negative correlation connection is established with such indicators as domination, conservatism, conformality characterizing a personality as non-confrontational, democratic in behaviour, independent. Development of emotional creativity is one of the problems of improvement of quality of modern university education. The tasks of formation of students’ qualities of the emotional and creative personality and the conditions of emotionally attractive learning through the usage of substantially semantic and active methods of training based on interaction, reflection, creativity are formulated on the basis of the received results. DOI: 10.5901/mjss.2015.v6n6s7p175
The anomalous behavior of physical-chemical parameters during polymerization of organic-inorganic polymer systems based on reactive oligomers (2011)

International audience
Abstract P1-21-03: Unique estrogen receptor alpha turnover, regulation and targeting in invasive lobular breast carcinoma (2020)

Abstract Invasive lobular breast carcinoma (ILC) accounts for 10-15% of breast cancers diagnosed annually. Evidence suggests that endocrine treatment response might differ between invasive ductal carcinoma (IDC) and ILC, and that patients with ILC have worse long-term survival. ILCs are more likely to be estrogen receptor alpha (ER/ERα) positive (90-95%) compared to IDCs (60-70%). We investigated whether there are differences in ER protein steady state levels and/or turn-over rates in ILC that might explain differences in response to endocrine therapy. Analysis of the TCGA dataset revealed lower levels of ESR1 mRNA (P = 0.002) and ERα protein (P = 0.038) in ER+ ILC (n = 137) compared to ER+ IDC (n = 554). Supporting this observation, analysis of tumors from patients treated at UPMC Magee-Women’s Hospital (ILC, n = 143; IDC, n = 877), showed lower ESR1 mRNA (P &amp;lt; 0.005) in ILC and similar ERα protein levels in both subtypes. In both datasets, the correlation between ESR1 mRNA and ERα protein was significantly weaker in ILC suggesting differential post-transcriptional regulation of ER. This was confirmed in in vitro studies showing 17β-estradiol (E2) decreased the rate of degradation and increased half-life of ERα in MDA-MB-134-VI and SUM44PE ILC cell lines, whereas the opposite was observed in IDC cell lines. Further analysis of MDA-MB-134-VI cells revealed that E2 downregulated ubiquitination pathway genes and failed to induce ubiquitination of ERα. To determine potential clinical relevance of our findings, we evaluated the effect of two selective estrogen receptor down-regulators (SERDs) on ERα turnover and E2-induced proliferation of IDC and ILC cell lines. While fulvestrant and AZD9496, a novel orally bioavailable SERD, showed similar effects in IDC cell lines, AZD9496 was less effective than fulvestrant in decreasing ERα protein stability and E2-induced proliferation in ILC cells. Furthermore, AZD9496 exhibited partial agonist activity in growth and gene expression assays in the absence of ligand. Collectively, our data provide evidence for distinct ligand-induced ERα turnover in ILC cell lines. In addition, the novel SERD AZD9496 displays partial agonist activity in ILC cells, and further studies should address whether these observations are causally linked. These results provide a strong rationale for inclusion of ILC subgroups into preclinical and clinical testing of SERDs. Citation Format: Jennifer M Atkinson, Sreeja Sreekumar, Kevin M Levine, Matthew J Sikora, Jian Chen, David J Dabbs, Carolin Meier, Ahmed Basudan, Nilgun Tasdemir, David Boone, Priscilla F McAuliffe, Rachel C Jankowitz, Adrian V Lee, Steffi Oesterreich. Unique estrogen receptor alpha turnover, regulation and targeting in invasive lobular breast carcinoma [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P1-21-03.
Chaos-Enhanced Firefly Algorithm with Automatic Parameter Tuning (2011)

Many metaheuristic algorithms are nature-inspired, and most are population-based. Particle swarm optimization is a good example as an efficient metaheuristic algorithm. Inspired by PSO, many new algorithms have been developed in recent years. For example, firefly algorithm was inspired by the flashing behaviour of fireflies. In this paper, the author extends the standard firefly algorithm further to introduce chaos-enhanced firefly algorithm with automatic parameter tuning, which results in two more variants of FA. The author first compares the performance of these algorithms, and then uses them to solve a benchmark design problem in engineering. Results obtained by other methods will be compared and analyzed.
Abnormal methylation of the calcitonin gene marks progression of chronic myelogenous leukemia (1991)

The clinical aspects of disease progression in chronic myelogenous leukemia (CML) are well established, but the nature of the molecular events responsible is not known. We have previously reported a consistent pattern of novel sites of methylation in the 5′ region of the calcitonin (CT) gene and other chromosome 11p loci in acute myelogenous and and lymphoid leukemias. In the present study, CT gene methylation patterns were investigated in peripheral blood from 51 patients with CML. Abnormal patterns were found in only 2 of 31 patients in chronic phase, but in 5 of 8 patients in accelerated phase, and in 11 of 12 patients in blast crisis (P less than .005). For one patient studied in blast crisis, abnormal CT gene methylation was found in the peripheral blast cells but not in the granulocytes. In two of three patients studied with CML and having normal peripheral cell patterns, abnormal patterns were found in marrow blast cells. In one patient, only partial normalization of the CT gene methylation pattern was seen after chemotherapy induction of a second chronic phase and the patient relapsed 5 months later. Our findings indicate that abnormal methylation of the 5′ region of the CT gene is regularly a marker of disease progression in CML which may prove clinically useful. This abnormal methylation site is part of an imbalance in DNA methylation that may play a role in the progressive genetic instability which characterizes the advancing stages of CML.
Parity-Time Symmetry and Exceptional Points for Flexural-Gravity Waves in Buoyant Thin-Plates (2020)

We derive and apply a transfer matrix method (M-matrix) coupling liquid surface waves and flexural-gravity waves in buoyant thin elastic plates. We analyze the scattering matrix (S-matrix) formalism for such waves propagating within a Fabry-Perot like system, which are solutions of a sixth order partial differential equation (PDE) supplied with adequate boundary conditions. We develop a parity-time (PT)-symmetry theory and its applications to thin elastic floating plates. The sixth order PDE governing the propagation of these waves leads to six by six M and S matrices, and results in specific physical properties of the PT-symmetric elastic plate systems. We show the effect of geometry and gain/loss on the asymmetric propagation of flexural-gravity waves, as well as a Fano-like line-shape of the reflection signature. Importantly, we show the possibility of obtaining coherent perfect absorber-laser (CPAL) using simple thin structures.
Correction to Virus Bioresistor (VBR) for the Detection of the Bladder Cancer Marker DJ-1 in Urine at 10 pM in One Minute (2020)

The author list contained an error: Gregory A. Weiss was not identified as a corresponding author. Both of the corresponding authors, Gregory A. Weiss and Reginald M. Penner, are indicated in this Addition and Correction.
Insights into the Electrochemical Behavior of Mercury on Graphene/SiC Electrodes (2019)

Fast and real time detection of Mercury (Hg) in aqueous solutions is a great challenge due to its bio-accumulative character and the detrimental effect on human health of this toxic element. Therefore, development of reliable sensing platforms is highly desirable. Current research is aiming at deep understanding of the electrochemical response of epitaxial graphene to Mercury exposure. By performing cyclic voltammetry and chronoamperometry measurements as well as density functional theory calculations, we elucidate the nature of Hg-involved oxidation-reduction reactions at the graphene electrode and shed light on the early stages of Hg electrodeposition. The obtained critical information of Hg behavior will be helpful for the design and processing of novel graphene-based sensors.
Bimetallic Ru–Pd and Trimetallic Ru–Pd–Cu Assemblies on the Carborane Cluster Surface (2021)

The synthesis of well-defined heterometallic complexes remains a frontier challenge in inorganic chemistry. We report an approach that relies on the sequential insertion of electrophilic metal fragments into electron-rich Ru-B bonds of the η<sup>2</sup>-BB-carboryne complex (POBBOP)Ru(CO)<sub>2</sub> [POBBOP = 1,7-OP(<sup>i</sup>Pr)<sub>2</sub>-<i>m</i>-2,6-dehydrocarborane]. Utilizing this synthetic strategy, bimetallic (POBBOP)(Ru)(CO)<sub>2</sub>[Pd(P<sup>t</sup>Bu<sub>3</sub>)] and trimetallic (POBBOP)(Ru)(CO)<sub>2</sub>[Pd(P<sup>t</sup>Bu<sub>3</sub>)](CuBr) complexes were selectively prepared. Structural and theoretical analysis of the features of chemical bonding within Ru-B-B-Cu and Ru-B-B-Pd fragments is presented.
Long-term effects of hydrogel properties on human chondrocyte behavior (2010)

Hydrogels provide a 3-dimensional network for embedded cells and offer promise for cartilage tissue engineering applications. Nature-derived hydrogels, including alginate, have been shown to enhance the chondrocyte phenotype but are variable and not entirely controllable. Synthetic hydrogels, including polyethylene glycol (PEG)-based matrices, have the advantage of repeatability and modularity; mechanical stiffness, cell adhesion, and degradability can be altered independently. In this study, we compared the long-term in vitro effects of different hydrogels (alginate and Factor XIIIa-cross-linked MMP-sensitive PEG at two stiffness levels) on the behavior of expanded human chondrocytes and the development of construct properties. Monolayer-expanded human chondrocytes remained viable throughout culture, but morphology varied greatly in different hydrogels. Chondrocytes were characteristically round in alginate but mostly spread in PEG gels at both concentrations. Chondrogenic gene (COL2A1, aggrecan) expression increased in all hydrogels, but alginate constructs had much higher expression levels of these genes (up to 90-fold for COL2A1), as well as proteoglycan 4, a functional marker of the superficial zone. Also, chondrocytes expressed COL1A1 and COL10A1, indicative of de-differentiation and hypertrophy. After 12 weeks, constructs with lower polymer content were stiffer than similar constructs with higher polymer content, with the highest compressive modulus measured in 2.5% PEG gels. Different materials and polymer concentrations have markedly different potency to affect chondrocyte behavior. While synthetic hydrogels offer many advantages over natural materials such as alginate, they must be further optimized to elicit desired chondrocyte responses for use as cartilage models and for development of functional tissue-engineered articular cartilage.
LaSrGaO4 substrate gives oriented crystalline YBa2Cu3O7−y films (1991)

As-grown YBa2Cu3O7−y (YBCO) thin films of 70 nm thickness have been prepared on LaSrGaO4(001), (100), and (110) single-crystal substrates at 700 °C using ArF laser ablation deposition. The c-axis oriented thin films with smooth surface morphology are obtained on LaSrGaO4 (001) and (100) substrates. The zero resistance temperatures (Tc) of the films on the (001) and (100) substrates are 90.0 K, and 88.1 K, respectively. On the (110) substrate, (110) YBCO planes grow epitaxially. The resistance perpendicular to the c axis in this film is 1/3 of that parallel to the c axis, showing Tc⊥=85.9 K and Tc∥=84.4 K, respectively. These results suggest that a LaSrGaO4 substrate having a low dielectric constant is an excellent substrate for the epitaxial growth and device application of high-Tc YBa2Cu3O7−y superconducting films.
DUAL CHANNEL ECHO POSTFILTERING FOR HANDS-FREE MOBILE TERMINALS (2012)

In mobile communications, speech is often degraded by ambient noise and acoustic echo. Both problems have attracted a high level of research interest over the last decades. Recently dual channel solutions for noise reduction have been investigated and can yield better performance than single channel solutions. This paper presents an analysis of the echo problem based on recordings with a handsfree dual channel mock-up phone and proposes a novel residual echo power spectral density (PSD) estimator that uses two microphone signals instead of one. The proposed PSD estimate is compared to an existing single channel residual echo PSD estimator before being assessed within an echo postfilter. Our experiments show that the proposed dual-channel echo PSD outperforms the single channel postfilter, especially at low signal to echo ratios.