gebhart/patrepeval huggingface dataset:
EXPERIMENTAL STUDIES OF HUMAN BLADDER CANCER: HETEROTRANSPLANTATION TO THE HAMSTER CHEEK POUCH (1967)

SUMMARY An experimental testing method was devised to study in vivo the chemo–responsiveness of human bladder tumours growing as xenografts in the hamster cheek pouch. These tumours maintained their human specificity. Some parallels were observed between the response of these tumours to 5–Fluorouracil and Mitomycin–C and clinical observations of the effectiveness of these drugs in treating patients with bladder cancer.
Adaptive mechanisms in gaze control : facts and theories (1985)

The book will be an important addition for researchers and clinicians interested in the vestibular system, eye movements, motor systems in general, and central nervous system correlates of learning. Science Review Neuroscience Letters
An early postinfection signal mediated by monoclonal anti-beta 2 microglobulin antibody is responsible for delayed production of human immunodeficiency virus type 1 in peripheral blood mononuclear cells (1990)

We recently found (C. Devaux, J. Boucraut, G. Poirier, P. Corbeau, F. Rey, M. Benkirane, B. Perarneau, F. Kourilsky, and J.C. Chermann, submitted for publication) a latency in the human immunodeficiency virus (HIV) type 1 cytopathic effect in the human T-cell lymphotropic virus type I immortalized T-cell line MT4 that was mediated by anti-beta 2 microglobulin (beta 2m) monoclonal antibodies (MAb). Here we describe a delay in viral particle production in peripheral blood mononuclear cells (PBMC) that was mediated by three (B1-1G6, B2-62-2, and HC11-151-1) of four anti-beta 2m MAb tested, the nonefficient MAb (C21-48A) being specific for an epitope on beta 2m that was masked by association with the human leukocyte antigen class I heavy chain. Experiments were designed to determine the mechanism of interference. PBMC incubated with anti-beta 2m MAb before viral exposure were not protected from HIV infection. In addition, anti-beta 2m MAb were not efficient in preventing syncytium formation between HIV-infected PBMC and CD4-positive MT4 cells. In contrast, anti-beta 2m MAb treatment of freshly infected PBMC significantly delayed HIV production in these cells. The window of cell sensitivity to anti-beta 2m MAb treatment took place during a very early post-HIV-binding stage. The possible mechanism of anti-beta 2m MAb action is discussed.
ChemInform Abstract: A NEW μ‐PEROXO COBALT(III) COMPLEX: KINETICS AND MECHANISM OF THE OXYGENATION OF THE BIS(O‐PHENYLENEDIAMINE)COBALT(II) ION (1984)

Abstract Methanollösungen eines Co(II)‐Salzes, die einen großen Überschuß an O‐Phenylendiamin (L) enthalten, absorbieren 0.5 Mol O 2 /Mol Co und führen zur Bildung des Ions (I).
Enhancements in mass cytometry for multiplexing samples and increasing cell detection rate (TECH3P.938) (2015)

Abstract Mass Cytometry uniquely enables high dimensional single cell proteomic analysis for systems-level discovery and comprehensive functional profiling applications. At the core of the technology are the ICP ion source and a fast elemental analyzer designed for metal-conjugated affinity reagents. We show how recent advancements in reagents, sample introduction system and the ion source have simplified data acquisition and improved data quality with the mass cytometry platform. Up to 20 samples from an experiment are barcoded with palladium-based cell tagging reagents, combined into one tube, and stained and run as one sample. This multiplexing improves data quality by eliminating sample-to-sample staining and running variation, increases experimental throughput by reducing the number of tubes that need to be processed and run, and reduces reagent consumption. Since each barcode consists of a unique set of 3 Pd isotopes, the de-barcoding algorithm also filters out most doublets (with more than 3 isotopes). The multiplexed sample is run on the CyTOF using the novel large volume sample introduction system. We will discuss results of modifications to the sample introduction system and the inductively coupled plasma ion source, which enable analysis of large samples at high cell detection rate. Examples of barcoded PBMCs from multiple donors, stained with high dimensional antibody panels that combine deep phenotyping with multiple cytokine or signaling targets will be demonstrated.
Binaural interference in multiple sclerosis: case study. (1995)

A case report of a young, adult male with multiple sclerosis who demonstrates binaural interference is presented. Binaural interference was demonstrated on behavioral and physiologic measures during the active stage. Binaural interference was present, although reduced, during the stage of remission. During remission, binaural interference occurred despite the absence of interaural asymmetry in the audiometric configuration or suprathreshold speech-recognition score. A trial period of left ear amplification was introduced. A possible explanation for the improvement in soundfield suprathreshold speech-recognition score with amplification is the reduction of the binaural-interference effect with monaural amplification of the affected ear when there is bilateral normal-hearing sensitivity.
Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in mice (2007)

Hops (Humulus lupulus, Cannabinaceae) has been used in traditional European medicine as a mild sedative for the treatment of anxiety, nervousness, and insomnia. However, there has been little information available about the underlying sleep inducing mechanism of hops. We have investigated the effects of a hops extract on the rectal body temperature in mice. Hops extract (250 mg kg(-1)) significantly decreased body temperature in male BL6/C57J mice (DeltaT -0.75 +/- 0.07 degrees C) 2 h after oral administration. The effects of the plant extract were comparable with melatonin (50 mg kg(-1); DeltaT -0.66 +/- 0.06 degrees C; 2 h after i.p. injection). The hypothermic effects of melatonin and hops extract were antagonized with the competitive melatonin receptor antagonist luzindole. Thus, our data suggests that the hypothermic--and therefore the sleep-inducing--effects of hops extract are possibly mediated through activation of melatonin receptors.
RCS reduction of dihedral corners (1977)

Corner reflectors are inadvertently formed by many surfaces on ships and military ground vehicles and can be dominant contributors to the radar cross section (RCS). The monostatic return from such structures can be reduced by ensuring that flat surfaces never meet at right angles. A criterion is developed that gives the required angle as a function of the RCS reduction desired and the electrical size of the corner faces.
Greening the internet with nano data centers (2009)

Motivated by increased concern over energy consumption in modern data centers, we propose a new, distributed computing platform called Nano Data Centers (NaDa). NaDa uses ISP-controlled home gateways to provide computing and storage services and adopts a managed peer-to-peer model to form a distributed data center infrastructure. To evaluate the potential for energy savings in NaDa platform we pick Video-on-Demand (VoD) services. We develop an energy consumption model for VoD in traditional and in NaDa data centers and evaluate this model using a large set of empirical VoD access data. We find that even under the most pessimistic scenarios, NaDa saves at least 20% to 30% of the energy compared to traditional data centers. These savings stem from energy-preserving properties inherent to NaDa such as the reuse of already committed baseline power on underutilized gateways, the avoidance of cooling costs, and the reduction of network energy consumption as a result of demand and service co-localization in NaDa.
In-Memory Computing: Advances and Prospects (2019)

IMC has the potential to address a critical and foundational challenge affecting computing platforms today -that is, the high energy and delay costs of moving data and accessing data from memory. In doing so, it takes a disruptive approach to computing systems that requires integrative research across the computing stack. This has appropriately ignited a wide range of research. It is necessary to understand the foundational tradeoffs arising from IMC to better grasp the challenges that must be addressed and evaluate the different approaches being proposed. From here, perspectives may be derived regarding the potential gains IMC can offer, the contexts and conditions on which these depend, and the support they require across the compute stack.
장애인복지의 정책수단유형에 대한 탐색적 연구: 제4차 장애인정책 종합계획을 중심으로 (2013)

본 연구는 정책 목표 달성을 위한 정책 수단들의 중요성을 인식하여 장애인복지정책을 중심으로 어떠한 정책수단이 활용되고 있는지? 그리고 사용되고 있는 정책수단들의 유형적 특징을 분석한 후 정책 수단의 활용에 함의를 도출하고자 하는 것이 목적이다. 이를 위하여 2013~2017년까지 시행되는 제4차 장애인정책종합계획을 대상으로 분석하였다. 제4차 장애인정책종합계획은 4개의 핵심 분야에 19개의 중점과제, 그리고 이를 더욱 세부화한 71개의 세부사업과제들로 구성되어 있는데 분석결과는 다음과 같았다. 제4차 장애인정책종합계획의 정책수단들은 간접규제를 제외한 직접규제 7개, 직접유인 4.5개, 직접 정보 2.5개, 준직접규제 2개, 준직접유인 4개, 준직접정보 5개, 간접유인 31개, 간접정보 15개를 사용하고 있었다. 이로써 장애인복지영역에서는 정책수단으로 강제성과 직접성이 낮은 간접유인과 간접정보 수단들이 세부과제의 약 2/3에 활용되고 있는 것으로 나타났다. 결국 정부의 직접공급은 거의 없고 강제성과 직접성이 낮은 정책수단들이 주로 활용되고 있어 효율성은 높지만 효과성을 담보할 수 있는 정책수단들이 부족하였다. 따라서 향후 정치적 책임성과 관리가능성을 높일 필요가 있다. 이를 위해 준직접규제와 민간의 자율규제인 간접규제 등이 확대될 필요가 있다. 이는 직접규제보다는 정치적 저항이나 가시성이 낮아서 도입하기가 훨씬 용이하다. 또한 간접유인과 간접정보에 집중화된 정책수단들을 정책과제에 맞추어 좀 더 유연하게 다양화하여 활용할 필요가 있다.
Note—Post-Infeasibility Analysis in Linear Programming (1979)

When a linear programming problem is found to have no feasible solution, the model-builder generally has no tools for systematically determining why the infeasibility exists and what might be done to eliminate it. The assumption is made, at least implicitly, that if the model has no feasible solution, it is wrong to some fundamental way and must be corrected before it can be of use to the model-builder. In fact, the model may be quite correct as it stands, in the sense that it captures exactly what the model-builder meant for it to capture. When this is the case, discovering the absence of a feasible solution can be useful to the model-builder, and correspondingly, tools for exploring the nature of the infeasiblity can be quite valuable. The purpose of this paper is to develop a set of methods for doing post-infeasibility analysis on linear programming problems. The methods are designed to identify constraints that might be “relaxed” to attain feasibility and estimate the magnitudes of the required changes.
Regulation and Function of NOTCH2 in B-CLL Cells. (2007)

Abstract B-cell chronic lymphocytic leukemia (B-CLL) represents a clonal expansion of self-reactive CD5+ B-lymphocytes which seems to be resistant to apoptosis in vivo. One of the characteristics of B-CLL lymphocytes is the high expression of the B-cell differentiation/activation marker CD23 which we recently identified as a target gene for NOTCH2 signaling. NOTCH2 is implicated in the development/homeostasis of murine CD5+ (B-1a) B-cells, suggesting a function for human NOTCH2 in B-CLL leukemogenesis. Here we show that peripheral B-CLL lymphocytes overexpress a transcriptionally active form of NOTCH2 (N2IC) irrespective of their prognostic marker profile (ie. IgVH mutational status, CD38 expression, and cytogenetics). Although the majority of unstimulated B-CLL samples downregulate their N2IC activity in vitro, DNA-bound N2IC complexes could be maintained by the protein kinase C (PKC) activator TPA (12-O-tetradecanoylphorbol 13-acetate) accompanied by an upregulation of the NOTCH2 target gene CD23 and increased B-CLL cell viability. These effects are sensitive to the PKC-δ selective inhibitor Rottlerin. In 80% of B-CLL cases, NOTCH2 signaling was found to be resistant to the γ-secretase inhibitors (GSI’s) Dapt and compound E, indicative for the expression of truncated forms of NOTCH2 which do not require γ-secretase for processing and function. Inhibition of NOTCH2 either by Dapt in GSI sensitive B-CLL cases or, more specifically, by RNA interference downregulates CD23 expression on the mRNA and protein level and sensitizes B-CLL cells for apoptosis. Since self-reactive B-cells are normally eliminated either by chronic (anergy) or apoptotic (negative selection) B-cell receptor (BCR) signaling, we asked whether NOTCH2 modulates B-cell fate decisions triggered by the BCR. For this reason, we stably transduced the human B-cell line BL41 with constitutive active forms of NOTCH2 and found that NOTCH2 inhibits BCR mediated apoptosis induced by surface-IgM cross-linking. In summary, the data demonstrate that NOTCH2 signaling is deregulated in B-CLL cells and might be critically involved in the PKC-dependent maintenance of their malignant phenotype.
Vilka elever antas till en idrottsskola (2019)

Denna artikel diskuterar rekryteringen till en högstadieskola som specialiserar sig på fysisk aktivitet och idrott. Två årgångar flickor och pojkar följs över tid, från 13 till 15 års ålder (n=176). De antogs till skolan i hård konkurrens med en grupp som sökte men inte kom in (n=437). De antagna valdes ut på grundval av sina idrottsliga meriter, inte utifrån deras betyg. Skolans idrottsverksamhet grundar sig därmed på talangidentifikation, och arbetar, förutom med skolkunskapsförmedling, med idrottslig talangutveckling. Vilka elever antas till en idrottsskola? Ett av syftena med den longitudinella och flervetenskapliga studien Malmö Youth Sport Study (MYSS) är att redovisa vilka som utväljs och att analysera resultatet utifrån olika faktorer – genusrelaterade, fysiska, psykologiska och sociala. Det visar sig att det finns ett antal sociala och socioekonomiska faktorer som påverkar talangidentifieringen. De faktorer som artikeln pekar på är föräldrarnas socioekonomiska status och omfattningen av deras idrottskapital, samt elevernas betyg och födelsekvartal.
Sociologues et consultants, du mépris à l'envie (1970-2016) (2016)

International audience
Crystal structures of pentafluoroxenon(1+) tetrafluorometallate(1-) (metal = silver, gold) and their relevance to the basicity and oxidizability of tetrafluorometallate(1-) (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal structures of pentafluoroxenon(1+) tetrafluorometallate(1-) (metal = silver, gold) and their relevance to the basicity and oxidizability of tetrafluorometallate(1-)Karel Lutar, Adolf Jesih, Ivan Leban, Boris Zemva, and Neil BartlettCite this: Inorg. Chem. 1989, 28, 18, 3467–3471Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/ic00317a014https://doi.org/10.1021/ic00317a014research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Use of endovascular stents in three dogs with Budd-Chiari syndrome (2009)

Endovascular stents may be an appropriate palliative treatment for dogs with clinical signs attributable to BCS.
Effectiveness of BNT162b2 COVID-19 Vaccination in Children and Adolescents (2023)

BNT162b2 protected children and adolescents against mild to moderate and severe COVID-19. VE was lower during Omicron predominance including BA.4/BA.5, waned after dose 2 but increased after a monovalent booster. Children and adolescents should receive all recommended COVID-19 vaccinations.
Synthesis of C1 inhibitor (C1-INA) by a human monocyte-like cell line, U937. (1985)

Human monocytes are known to synthesize many of the components of complement, including C1-INA. In this report we demonstrate that the human monocyte-like cell line U937 is also capable of synthesizing functional C1-INA. This was shown in several ways, including 1) incorporation of tritiated amino acids into antigenic C1-INA, immunoprecipitation, and detection by fluorography; 2) a sensitive ELISA, which allowed quantitation of antigenic C1-INA in cell lysates, and 3) a C2-dependent hemolytic assay in which the functional activity of U937 C1-INA was assayed. Data from the ELISA indicate that U937 cells contain between 2.1 to 12.8 ng of C1-INA per 1 X 10(6) cells. Furthermore, fluorescence-activated cell sorter analysis revealed that approximately 16% of U937 cells carry C1-INA as a surface bound antigen. Other proteins found to be synthesized by U937 cells include C1r, C8, and possibly alpha-2-macroglobulin. These results suggest that the U937 cell line could be a convenient and valuable model for the study of monocyte C1-INA synthesis and physiology.
An in vitro/ex vivo human lung infection model for studying the macrophage innate immune response to Ebola virus Kikwit (2018)

Abstract Ebola virus causes a severe and often fatal hemorrhagic fever in people, for which no approved vaccines or therapeutics are available. Disease pathogenesis and countermeasure studies are typically performed using animal models; however, ex vivo models recapitulating human immune responses may provide valuable information. We optimized engineered lung tissue constructs comprised of human lung epithelial cells and human endothelial cells that mimic the vascularized lower airway alveolar tissue micro-environment to study the human innate immune response to Ebola virus Kikwit (EBOV/Kik). Human lung tissue macrophages are difficult to obtain due to practical and ethical considerations, so macrophages were chemically derived from human monocytes. We inoculated the constructs, in the presence and absence of monocyte derived macrophages (MDM), and quantified cytokines/chemokines secreted on days 0, 3, 6, 9, and 15 post-infection using 29-plex and 1-plex human cytokine/chemokine kits. Prior to infection, MDM were secreting IL-13, MCP-1, MIP-1a, MIP-1b; however, these levels rapidly declined by day 3 post-infection (pi). The MDM secreted peak levels of IL-4, IFN-a2, Eotaxin, IL-12P40, and IFNg at day 6pi, and IL-1ra peaked at day 9 pi. In response to EBOV/Kik, the human lung epithelial cells in the engineered lung tissue construct secreted G-CSF, IL-1ra, IL-8, IP-10, and PDGF-AA/BB. G-CSF and IL-8, cytokines known to mobilize hematopoietic progenitors from bone marrow to blood and recruit neutrophils to sites of infection, were abundantly secreted by both endothelial cells and macrophages in response to infection. This model system may be a valuable resource to the field to study human immune responses during acute infections.
3D recording for archaeological fieldwork (2003)

Until recently, archaeologists have had limited 3D recording options because of the complexity and expense of the necessary recording equipment. We outline a system that helps archaeologists acquire 3D models without using equipment more complex or delicate than a standard digital camera.
Identification of the Catalytic Residues of α-Amino Acid Ester Hydrolase from Acetobacter turbidans by Labeling and Site-directed Mutagenesis (2002)

The alpha-amino acid ester hydrolase from Acetobacter turbidans ATCC 9325 is capable of hydrolyzing and synthesizing the side chain peptide bond in beta-lactam antibiotics. Data base searches revealed that the enzyme contains an active site serine consensus sequence Gly-X-Ser-Tyr-X-Gly that is also found in X-prolyl dipeptidyl aminopeptidase. The serine hydrolase inhibitor p-nitrophenyl-p'-guanidino-benzoate appeared to be an active site titrant and was used to label the alpha-amino acid ester hydrolase. Electrospray mass spectrometry and tandem mass spectrometry analysis of peptides from a CNBr digest of the labeled protein showed that Ser(205), situated in the consensus sequence, becomes covalently modified by reaction with the inhibitor. Extended sequence analysis showed alignment of this Ser(205) with the catalytic nucleophile of some alpha/beta-hydrolase fold enzymes, which posses a catalytic triad composed of a nucleophile, an acid, and a base. Based on the alignments, 10 amino acids were selected for site-directed mutagenesis (Arg(85), Asp(86), Tyr(143), Ser(156), Ser(205), Tyr(206), Asp(338), His(370), Asp(509), and His(610)). Mutation of Ser(205), Asp(338,) or His(370) to an alanine almost fully inactivated the enzyme, whereas mutation of the other residues did not seriously affect the enzyme activity. Circular dichroism measurements showed that the inactivation was not caused by drastic changes in the tertiary structure. Therefore, we conclude that the catalytic domain of the alpha-amino acid ester hydrolase has an alpha/beta-hydrolase fold structure with a catalytic triad of Ser(205), Asp(338), and His(370). This distinguishes the alpha-amino acid ester hydrolase from the Ntn-hydrolase family of beta-lactam antibiotic acylases.
Current source inverter with bi-directional switches (2023)

A switching circuit includes a diode, a semiconductor switch, and a first bidirectional switch. The semiconductor switch is configured to conduct a first current from a second terminal to a third terminal of the semiconductor switch when a first on-state signal is sent to a first terminal of the semiconductor switch. An anode of the diode is connected to the second terminal of the semiconductor switch, and a cathode of the diode is connected to the third terminal of the semiconductor switch. The first bidirectional switch includes a first terminal, a second terminal connected to the anode of the diode, and a third terminal and is configured to conduct a second current from the second terminal to the third terminal or from the third terminal to the second terminal when a second on-state signal is sent to the first terminal of the first bidirectional switch.
1306 Active Seat Suspension for a Small Vehicle : Considerations for Sensory Evaluation with Multiple Regression Analysis (2005)

A small active seat suspension has been designed and manufactured for a one-seat electric vehicle. Our aim was to develop a vibration-isolation system for the driver's seat suspension using active control. However, the evaluation of ride comfort during the electric vehicle running has depended on subjective judgement by drivers. Thus, it is necessary to evaluate the correlation of subjective judgement with objective judgement according to physical values, i.e., vibrations. In this study, ride comfort ratings evaluated subjectively by the "Paired Comparison Method" were compared with the measured acceleration of the seat surface. As a result, we confirmed a good correlation between the subjective judgement and the physical values.
[Participation of hippocampal neurons on the stages of feeding behavior]. (1977)

Activity of 65 hippocampal single units was recorded during an instrumental feeding behaviour in three rabbits. Different neurons fire or change their spontaneous activity in one or more behavioural acts, which constitute the consecutive behaviour. In one or the other behavioural act single unit discharges occur both after and before some intermediate results. Participation of hippocampus in organization of the consecutive behaviour is discussed.