gebhart/patrepeval huggingface dataset:
Differential Expression of HtrA1 and ADAM12 in Placentas from Preeclamptic and Normotensive Pregnancies (2012)

Increases in HtRA1 and ADAM12 placental gene expression in placentas from preeclamptic pregnancies are consistent with some earlier reports of altered serum protein concentrations in preeclamptic pregnancies. This adds to the literature suggesting that defects in placentation (e.g. involving trophoblast invasion) are of etiologic importance in preeclampsia.
Environmental Enteric Dysfunction and the Fecal Microbiota in Malawian Children (2016)

Environmental enteric dysfunction (EED) is often measured with a dual sugar absorption test and implicated as a causative factor in childhood stunting. Disturbances in the gut microbiota are hypothesized to be a mechanism by which EED is exacerbated, although this supposition lacks support. We performed 16S ribosomal RNA gene sequencing of fecal samples from 81 rural Malawian children with varying degrees of EED to determine which bacterial taxa were associated with EED. At the phyla level, Proteobacteria abundance is reduced with severe EED. Among bacterial genera, <i>Megasphaera</i>, <i>Mitsuokella</i>, and <i>Sutterella</i> were higher in EED and <i>Succinivibrio</i>, <i>Klebsiella</i>, and <i>Clostridium_XI</i> were lower in EED. Bacterial diversity did not vary with the extent of EED. Though EED is a condition that is typically believed to affect the proximal small bowel, and our focus was on stool, our data do suggest that there are intraluminal microbial differences that reflect, or plausibly lead to, EED.
Development of stimuli-responsive intelligent polymer micelles for the delivery of doxorubicin (2020)

Doxorubicin is still used as a first-line drug in current therapeutics for numerous types of malignant tumours (including lymphoma, transplantable leukaemia and solid tumour). Nevertheless, to overcome the serious side effects like cardiotoxicity and myelosuppression caused by effective doses of doxorubicin remains as a world-class puzzle. In recent years, the usage of biocompatible polymeric nanomaterials to form an intelligently sensitive carrier for the targeted release in tumour microenvironment has attracted wide attention. These different intelligent polymeric micelles (PMs) could change the pharmacokinetics process of drugs or respond in the special microenvironment of tumour site to maximise the efficacy and reduce the toxicity of doxorubicin in other tissues and organs. Several intelligent PMs have already been in the clinical research stage and planned for market. Therefore, related research remains active, and the latest nanotechnology approaches for doxorubicin delivery are always in the spotlight. Centring on the model drugs doxorubicin, this review summarised the mechanisms of PMs, classified the polymers used in the application of doxorubicin delivery and discussed some interesting and imaginative smart PMs in recent years.
Exact treatment of leaky Rayleigh waves in the presence of a layer (1981)

An exact theory, supported by experimental measurements, of bounded acoustic-beam reflection near the Rayleigh angle from a fluid-solid interface loaded by a solid layer is presented. We derive an analytical expression for the reflection coefficient by applying continuity conditions appropriate for the problem geometry to wave potentials in the three media. The reflected field, including leaky Rayleigh-wave effects, is calculated by evaluating numerically the Fourier integral containing the incident beam transform and the reflection coefficient. The dispersion of the Rayleigh wave speed is deduced from the behavior of the reflection coefficient in the complex plane. We find excellent agreement with measurements of the wave speed over a wide range of frequency and layer thickness in stainless steel samples loaded with copper layers. The beam displacement parameter, which is also deduced from characteristics of the reflection coefficient, displays an unexpected minimum as a function of frequency. Experimental results are compared to theory for the acoustic amplitude distribution in the reflected field, both near and at the Rayleigh angle.
Dynamic and static tomographic renal coincidence imaging with a gamma camera using Rb-82: a feasibility study (2002)

Rb-82, a positron emitter with a half-life of /spl sim/75 s, is a promising radionuclide that can potentially turn the concept of sequential dynamic tomographic renal imaging into reality. In this preliminary investigation, we explored several aspects of renal imaging with Rb-82 on a hybrid single photon emission computed tomography (SPECT)-positron emission tomography (PET) system, which relate to the feasibility of such imaging. First, the resolution of Rb-82 was approximated using the Deluxe ECT phantom with solid spheres (0.95 to 3.18 cm in diameter) and compared with Tc-99m. In addition, the impact of spatial resolution was assessed in-vivo in terms of the visualization of wax objects placed in the kidneys. Furthermore, the possibility of performing dynamic and static tomographic Rb-82 renal imaging was explored. A single 3-mCi Rb-82 bolus and limited angle tomography were used for dynamic imaging, while multiple bolus infusions in combination with either single- or multiple-step acquisitions were used for static imaging. Renal acquisitions were done using New Zealand White Rabbits weighing between 4 and 7 kg. Similar visualization of the cold spheres was noted in the phantom, and better visualization of the wax inserts was noted in the in vivo study for Rb-82 compared to Tc-99m. With decay and resolving time loss correction, the limited-angle dynamic tomographic studies showed the kidneys to have the highest uptake of any organ by 20-30 s. The renal uptake continued to increase up to 120-150 s when it became approximately constant. This significant and relatively constant renal uptake of Rb-82 allowed full tomographic imaging of the kidneys to be performed with multiple bolus infusions. In conclusion, we showed that it is possible to do dynamic renal imaging and due to the short half-life, acquisitions can be repeated every 7 min. This gives the clinician a powerful tool to track changes in the kidney over short intervals.
High-Resolution All-Digital Transmit Beamformer for High-Frequency and Wearable Ultrasound Imaging Systems (2019)

In this article, we present a high delay resolution and all-digital transmit-beamforming circuit for use in high-frequency and wearable ultrasound imaging systems. The proposed transmit beamformer comprises an all-digital delay-locked loop (ADDLL), a cycle-based beamforming delay line (CBDL), and a pulse controller. ADDLL can provide specific digital control code for the CBDL to generate stable and suitable delays to excite array transducer elements without variations in process, voltage, and temperature. CBDL not only provides a finer delay resolution for high-frequency ultrasound imaging systems but also requires a few delay cells to maintain the duty cycle of long prorogation signals, thereby significantly reducing hardware costs. The pulse controller can adjust the number and width of output pulses to meet the requirements of different ultrasonic transducers and Doppler ultrasound color imaging. The proposed transmit beamformer uses a 0.18- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> CMOS technology for a 30-MHz high-frequency linear array with 256 elements, and the focusing depth is from 3.5 to 8.1 mm. The measurement results indicate that the proposed transmit-beamforming design can achieve a maximum time delay of 562.6 ns with an average time resolution of 535 ps. The proposed design offers a smaller volume and finer delay resolution, and it is highly suitable for wearable ultrasound imaging systems.
Perturbation of canonical and non-canonical BMP signaling affects migration, polarity and dendritogenesis of mouse cortical neurons (2018)

Bone morphogenetic protein (BMP) signaling has been implicated in the regulation of patterning of the forebrain and as a regulator of neurogenesis and gliogenesis in the mammalian cortex. However, its role in other aspects of cortical development <i>in vivo</i> remains unexplored. We hypothesized that BMP signaling might regulate additional processes during the development of cortical neurons after observing active BMP signaling in a spatiotemporally dynamic pattern in the mouse cortex. Our investigation revealed that BMP signaling specifically regulates the migration, polarity and the dendritic morphology of upper layer cortical neurons born at E15.5. On further dissection of the role of canonical and non-canonical BMP signaling in each of these processes, we found that migration of these neurons is regulated by both pathways. Their polarity, however, appears to be affected more strongly by canonical BMP signaling, whereas dendritic branch formation appears to be somewhat more strongly affected by LIMK-mediated non-canonical BMP signaling.
Human Cochlear Aqueduct and its Accessory Canals (1977)

The anatomy of the adult human cochlear aqueduct and its surrounding structures, and their normal variations at tomography, microdissection and plastic molding are described. The mean length of the aqueduct is 12.9 mm and the mean width of its funnel-shaped external aperture 4.2 mm. The mean width of the narrowest portion is 0.14 mm. No difference in aqueductal width was found between the youngest and oldest age groups. Complete bony obstruction was revealed at microdissection in 3 out of 82 specimens. In the remaining 79 the entire aqueduct was patent. The aqueduct usually runs parallel to the internal auditory canal when seen from above, and the AP projection is therefore most suitable for tomography. At tomography the entire aqueduct was visualized in 60% of the specimens. The isthmic portion was not visible in 40%. Major reasons for nonvisualization of the entire aqueduct are: 1) a luminal width less than 0.1 mm, 2) a high jugular fossa, 3) a posteriorly directed aqueductal convexity (10%), and 4) bony obliteration (4)%). Accessory canals close to and often wider than the aqueduct may complicate tomographic evaluation of the aqueductal patency. Nonvisualization of the aqueduct at tomography does not necessarily indicate nonpatency.
Long-Lifetime True Green Laser Diodes with Output Power over 50 mW above 525 nm Grown on Semipolar $\{20\bar{2}1\}$ GaN Substrates (2012)

True green GaInN laser diodes with a lasing wavelength above 525 nm under continuous wave operation have been successfully fabricated on semipolar {2021} GaN substrates by improving both the diode structure and epitaxial growth conditions. At a case temperature of 55 °C, their lifetime was estimated to be over 5000 h for an optical output power of 50 mW and over 2000 h at 70 mW.
Cranberry metabolites in urine inhibit bacterial adhesion (2009)

Drinking cranberry juice has been shown to prevent urinary tract infections (UTIs) in some clinical studies, but the mechanisms for this benefit remain unclear. It is suggested that cranberry metabolites in urine help prevent bacterial adhesion to uroepithelial cells, which is the first step of infection. We used atomic force microscopy (AFM) to determine the adhesion forces between a clinical strain of E. coli (CFT073) and a silicon nitride probe. Bacteria were bound to a glass slide and incubated in urine for 45 minutes. Urine samples were collected from a volunteer at 0, 2, 4, 6, or 8 hours after consuming 16 oz of either cranberry juice cocktail (CJC) or water. The AFM analysis demonstrated the adhesion forces of bacteria incubated in urine after CJC consumption were lower than those of bacteria incubated in urine after water consumption. whereas bacterial adhesion forces in samples with cranberry metabolites decreased from 1.25 plusmn 0.75 nN (0 hrs after consumption) to 0.38 plusmn 0.2 nN (8 hrs after consumption), adhesion forces in samples collected after water consumption showed no statistically significant temporal difference. These results suggest that cranberry metabolites in urine can inhibit bacterial adhesion for at least 8 hours after consumption.
Thymectomy and Chronic Relapsing Experimental Allergic Encephalomyelitis in Guinea Pigs (1984)

Chronic relapsing experimental allergic encephalomyelitis (EAE) was induced in young Dunkin Hartley guinea pigs by a single sensitization with guinea pig spinal cord homogenate. The effect of either newborn thymectomy or young adult thymectomy on the clinical course of chronic and relapsing EAE was studied and evaluated statistically by Student's t test. All the animals that underwent thymectomy showed a significant delay in the onset of the disease compared with control groups. In addition, in the young adult guinea pigs in which thymectomy was done, the incidence of clinical disease was decreased. No substantial differences, however, were observed in the severity of the disease and number of remissions or relapses between guinea pigs in which thymectomy was done and in which clinical symptoms developed and controls.
Digital signal processing software packages for IBM-PC and IBM-PC with DSP-16. (1989)

NA
A Computational Method for Modeling Fracture in Disordered Media: From Single Crack Growth to Fragmentation. (2011)

Abstract not provided.
Partitioned garbage collection of a large object store (1997)

We present new techniques for efficient garbage collection in a large persistent object store. The store is divided into partitions that are collected independently using information about inter-partition references. This information is maintained on disk so that it can be recovered after a crash. We use new techniques to organize and update this information while avoiding disk accesses. We also present a new global marking scheme to collect cyclic garbage across partitions. Global marking is piggybacked on partitioned collection; the result is an efficient scheme that preserves the localized nature of partitioned collection, yet is able to collect all garbage.
Isolation of Large-Terminal Sequences of BAC Inserts Based on Double-Restriction-Enzyme Digestion Followed by Anchored PCR (2003)

Large insert libraries are critical in genome-related research. Bacterial artificial chromosome (BAC) libraries are widely used in plant, animal, and human research; the ends of BAC clones are used as probes for chromosome walking and to confirm overlapping of contigs, as well as RFLP markers for mapping. Several methods have been developed to isolate BAC ends, including subcloning methods, plasmid rescue, and polymerase chain reaction (PCR)-based methods such as inverse PCR, thermal asymmetric interlaced PCR (TAIL-PCR), and Vectorette PCR (1, and references therein). Here, we described BAC end isolation based on double-restriction-enzyme digestion followed by anchored PCR. The BAC vector in the examples used here is pBeloBAC11 (2). Other vectors can be used, but the specific designation of left or right ends as used here may be different depending on the particular vector used.
An overview of electrical burns (1998)

Although patients with electrical burns constitute only about 5 % of the patients admitted with burns, the injury is often devastating for the patient. Because of injury to vital structures like nerves and tendons, there is a very high incidence of loss of function apart from a high rate of amputation. Various theories have been given to explain the pathophysiology and the typical pattern of injury seen in the electric burn. Our experience of large number of patients at Safdarjang hospital shows that the blood vessels show the least resistance to electrical current and the typical distribution of injury in the wrist, elbow and axilla can be explained on this. The progression of injury is due to venous and arterial thrombosis and early intervention must be aimed at augmenting it by flap cover.
Photon Irradiation Effects on Oxide Surface Electrochemistry and Oxide Microstructure of Zircaloy 4 in High-Temperature Water (2021)

Although there exists a correlation between autoclave and in-reactor zirconium alloy performances, consistent oxidation kinetics discrepancies in these two environments have been observed and a fundamental understanding of the oxidation kinetics enhancement under irradiation is still lacking. Recent results obtained at the Advanced Test Reactor by the Naval Nuclear Laboratory show that photon irradiation significantly affects zirconium corrosion kinetics. In reactors, various photon sources are present in the core from ultraviolet (UV) to gamma (γ) rays. This study aims at characterizing the effect of UV and γ rays on the corrosion mechanism of Zircaloy-4. To this end, a state-of-the-art autoclave equipped with sapphire windows and connected to a recirculation loop has been installed. Zircaloy-4 coupons were exposed for 7 days at 260°C with and without recirculation or UV irradiation (or both). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) oxide characterizations show the presence of iron (Fe)-rich oxide deposits on top of the zirconium oxide where the sample has been irradiated by UV. The deposit concentration is larger in the static corrosion case and does not significantly influence the zirconium oxidation kinetics. A mechanism is proposed to explain the nucleation of these deposits and the relationship to Chalk River Unidentified Deposit nucleation is discussed. In another experiment, Zircaloy-4 coupons have been irradiated at the MIT reactor in neutron+gamma, gamma, and unirradiated loop conditions. The in-core specimens were exposed to ~1021 n/m2 fast neutron fluence in 290°C water at 7 MPa. Oxide layers have been characterized by SEM and TEM. The oxide grain size, t-ZrO2 fraction, fiber texture, and m-ZrO2 twin boundaries’ density were characterized. The results indicate that, at low dpa, the neutron + γ irradiated sample has a more protective oxide than the γ-irradiated sample, which has a more protective oxide than the nonirradiated sample.
Key to effective video retrieval (1998)

Article Key to effective video retrieval: effective cataloging and browsing Share on Authors: Dulce Ponceleon IBM Almaden Research Center, 650 Harry Road, San Jose, CA IBM Almaden Research Center, 650 Harry Road, San Jose, CAView Profile , Savitha Srinivasan IBM Almaden Research Center, 650 Harry Road, San Jose, CA IBM Almaden Research Center, 650 Harry Road, San Jose, CAView Profile , Arnon Amir IBM Almaden Research Center, 650 Harry Road, San Jose, CA IBM Almaden Research Center, 650 Harry Road, San Jose, CAView Profile , Dragutin Petkovic IBM Almaden Research Center, 650 Harry Road, San Jose, CA IBM Almaden Research Center, 650 Harry Road, San Jose, CAView Profile , Dan Diklic School of Engineering, Santa Clara University, 500 El Camino Real, Santa Clara, CA School of Engineering, Santa Clara University, 500 El Camino Real, Santa Clara, CAView Profile Authors Info & Claims MULTIMEDIA '98: Proceedings of the sixth ACM international conference on MultimediaSeptember 1998 Pages 99–107https://doi.org/10.1145/290747.290760Published:01 September 1998 40citation1,156DownloadsMetricsTotal Citations40Total Downloads1,156Last 12 Months13Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Reflexões sobre o Programa de Pós-Graduação em História Social - trinta anos (2012)

Em julho de 2012, em celebração dos trinta anos de criação do Programa de Pós-Graduação em História Social da Universidade Federal do Rio de Janeiro, o Comitê Editorial de Topoi solicitou a Francisco Falcon que escrevesse uma narrativa acerca das origens e do desenvolvimento do programa. Esse texto foi, a seguir, enviado a José Murilo de Carvalho e Marieta de Moraes Ferreira, que por sua vez desenvolveram suas próprias reflexões a partir das questões propostas por Francisco Falcon. Publicamos aqui este diálogo entre três professores que não só participaram da construção do PPGHIS, mas que ajudaram a desenvolver os estudos de pós-graduação em história no Brasil.
Molecular Cloning and Sequence of a Cholesterol-Repressible Enzyme Related to Prenyltransferase in the Isoprene Biosynthetic Pathway (1987)

Differential hybridization and molecular cloning have been used to isolate CR39, a cDNA which hybridizes to a 1.2-kilobase (kb) mRNA in rat liver. The level of CR39 mRNA was increased seven- to ninefold over normal levels by dietary cholestyramine and mevinolin and decreased about fourfold compared with normal levels by cholesterol feeding or administration of mevalonate. Similar changes in the mRNA levels of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and HMG-CoA synthase were observed under the various conditions. In vitro translation of either CR39 hybrid selected RNA or 1.2-kb CR39 RNA generated by an SP6 in vitro transcription system produced a polypeptide of 39,000 daltons. As deduced from the nucleotide sequence of a full-length CR39 cDNA, the rat CR39 polypeptide contained 344 amino acids and had a molecular weight of 39,615. The predicted amino acid composition and submit molecular weight of the rat CR39 were very similar to those of prenyltransferases isolated from chicken, pig, and human. The sequence of amino acid residues 173 through 203 in the rat CR39 polypeptide showed that 17 out of 30 matched an active-site peptide of avian liver prenyltransferase. Thus, alterations in the rate of cholesterogenesis resulted in the coordinate regulation of three mRNAs encoding HMG-CoA reductase, HMG-CoA synthase, and CR39, the latter being tentatively identified as prenyltransferase.