gebhart/patrepeval huggingface dataset:
Data from Calcium-Binding Proteins S100A8 and S100A9 as Novel Diagnostic Markers in Human Prostate Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; S100 proteins comprise a family of calcium-modulated proteins that have recently been associated with epithelial tumors. We examined the expression of two members of this family, S100A8 and S100A9, together with the S100 receptor RAGE (receptor for advanced glycation end products) in human prostate adenocarcinomas and in prostatic intraepithelial neoplasia.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Tissue specimens of 75 patients with organ-confined prostate cancer of different grades were analyzed by immunohistochemistry for expression of S100A8, S100A9, and RAGE. In addition, &lt;i&gt;in situ&lt;/i&gt; hybridization of S100A8 and S100A9 was done for 20 cases. An ELISA was applied to determine serum concentrations of S100A9 in cancer patients compared with healthy controls or to patients with benign prostatic hyperplasia (BPH).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; S100A8, S100A9, and RAGE were up-regulated in prostatic intraepithelial neoplasia and preferentially in high-grade adenocarcinomas, whereas benign tissue was negative or showed weak expression of the proteins. There was a high degree of overlap of S100A8 and S100A9 expression patterns and of S100A8 or S100A9 and RAGE, respectively. Frequently, a gradient within the tumor tissue with an increased expression toward the invaded stroma of the prostate was observed. S100A9 serum levels were significantly elevated in cancer patients compared with BPH patients or healthy individuals.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; Our data suggest that enhanced expression of S100A8, S100A9, and RAGE is an early event in prostate tumorigenesis and may contribute to development and progression or extension of prostate carcinomas. Furthermore, S100A9 in serum may serve as useful marker to discriminate between prostate cancer and BPH.&lt;/p&gt;&lt;/div&gt;
Microstructural Characterization of Resistance Artery Remodelling in Diabetes Mellitus (2021)

Our results suggest diabetic microvascular remodelling is likely to be stress-driven, comprising at least 2 stages: (1) Laying down of adventitial bracing fibres that limit outward distension, and (2) Deposition of additional collagen in the media, likely due to the significantly altered mechanical environment. This work represents a step towards elucidating the local stress environment of cells, which is crucial to build accurate models of mechanotransduction in disease.
Recommendations for the detection and diagnosis of Niemann-Pick disease type C (2017)

This publication provides expert recommendations for clinicians who may see patients presenting with the signs and symptoms of NP-C, including general practitioners, pediatricians, neurologists, and psychiatrists.
A Framework of Design for Affordances Using Affordance Feature Repositories (2012)

People interact with artifacts, either products or services, in their lives. These interactions are based on two-way communication between people and artifacts. The characteristics of artifacts that induce natural activities of people, affordances, play critical roles in making interactions successful and meaningful. The notion of affordance features, structural elements of artifacts that provide affordances, has been proposed earlier. In this paper, a methodological framework for design for affordances is proposed where repository of affordance features are used. First affordances are identified through function-task interaction matrices or use activity observations. Using affordance feature repository where many alternative structural elements for a specific affordance are stored together with corresponding design constraints and contexts, affordance features for those identified affordances are retrieved considering similarities between the target design constrains and context and those of the affordance features in the repository. Using the clues given by such affordance features, the new affordance feature is to be designed through an analogical reasoning. We present this design for affordance framework as well as an illustrative case where various designers designed affordance features of a tumbler coffee cup using an affordance feature repository.
Potential targeting of Hep3B liver cancer cells by lupeol isolated from Avicennia marina (2021)

Medicinal plants are valuable sources of different active constituents that are known to have important pharmacological activities including anticancer effects. Lupeol, a pentacyclic triterpenoid, present in many medicinal plants, has a wide range of biological activities. Although the anticancer activity of lupeol was reported, the published data are inconsistent and the clear mechanism of action has never been assigned. The current study aims at investigating the anticancer specificity and mechanism of lupeol isolated from Avicennia marina, which grows in the desert of the United Arab Emirates. The compound was purified by chromatography and identified by spectroscopy. Compared with a negative control, lupeol caused significant (p < .001) growth inhibitory activity on MCF-7 and Hep3B parental and resistant cells by 45%, 46%, 72%, and 35%, respectively. The mechanism of action of lupeol was further explored by measuring its effect on key players in cancer development and progression, BCL-2 anti-apoptotic and BAX pro-apoptotic proteins. Lupeol significantly (p < .01) downregulated BCL-2 gene expression in parental and resistant Hep3B cells by 33 and 3.5 times, respectively, contributing to the induction of apoptosis in Hep3B cells, whereas it caused no effect on BAX. Furthermore, the immunoblotting analysis revealed that lupeol cleaved the executioner caspase-3 into its active form. Interestingly, lupeol showed no significant effect on the proliferation of monocytes, whereas it caused an increase in the sub-G1 population and a reduction in the apoptosis rates of monocytes at 48 and 72 h, indicative of no immuno-inflammatory responses. Collectively, lupeol can be considered as promising effective and safe anticancer agent, particularly against Hep3B cancer cells.
Single shot transient suppressor (SSTS) for high current high slew rate microprocessor (1999)

Future generation microprocessors are predicted to exhibit heavier loads and faster transients. Conventional voltage regulator modules (VRM) need a large amount of output filter capacitors to meet future requirements and a huge number of decoupling capacitors, mainly due to the presence of parasitic inductance between the VRM and the microprocessor. In this paper, a new active damp concept is presented. By charging some auxiliary capacitors at higher voltage, it is possible to store the amount of charge required by the processor during the step up transient; this extra charge can be locally delivered to the processor in a single shot manner, bypassing the slower VRM. In the same way, this circuit can sink the excess of charge that has to be removed during the step down transient. By using this transient suppressor circuit, a conventional VRM can still provide adequate steady state regulation, while the size of decoupling and filter capacitors can be significantly reduced. Experimental results prove the validity of the concept.
Impact of proton irradiation on strained triple gate SOI p- and n-MOSFETs (2011)

In this work the proton irradiation influence on basic and analog parameters of triple-gate SOI MOSFETs is investigated. The studied devices are strained and unstrained p- and nMuGFETs. The type of stress considered in each case, was the stress that results in a better performance of p- (CESL) and n-devices (sSOI+CESL). Although the results showed the worse behavior for post-irradiated nMOS transistors, a higher immunity to the back interface influence was obtained for post-irradiated pMOS devices and consequently a better analog performance was observed. The unit gain frequency improved for p and nMOS post-irradiated devices.
Block motion estimation using Directional Adaptive Search Window with Early Termination (2007)

Motion estimation (ME) is an important part of H.264 and other video compression standards, which eliminates temporal redundancies at the expense of higher computational complexity. Many adaptive methods have been proposed to reduce the amount of computation involved in ME. In this paper, two improvements are added to the technique using directional adaptive search window (DASW) method: directional search process and early termination. DASW alone can achieve a savings in number of search point computations of between 42% to 60%. By introducing early termination(ET) into motion estimation using DASW, the number of computations could be reduced even further since the search process is terminated immediately if the block is considered as a stationary block. However, DASW-ET incurs a slight degradation of less than 1 dB, in PSNR performance.
Minimum number of links needed for fault-tolerance in cluster-based network (1991)

One of the most difficult problems in network management for large computer networks is to manage a huge amount of network information. The way to overcome the difficulty is to introduce hierarchical control for network management. Additionally, it is said that a locality has a very important role for the design of hierarchical computer networks. The paper proposes a new fault-tolerant topology in a cluster-based network with respect to the locality. The following results are obtained: (1) At least 2n-2 links are needed in the cluster with the fault-tolerant topology, where n is the number of border nodes in the cluster. (2) As far as network connectivity is not losing, updating of routing information at each node can be localized within only the cluster containing failed links.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Developments in plasma enhanced spatial ALD for high throughput applications [3.04] (2016)

Atomic layer deposition by means of spatial separation of reactive gases is emerging as an industrial manufacturing technology. Integration of non-thermal plasma in spatial ALD machines will further expand the process window towards lower operation temperatures and specific materials requiring radicals (O, N, H, OH, NH etc.). Plasma sources with exceptional dimensional and chemical stability providing flow geometries optimized for efficient radical transport are needed. This paper reports on the initial steps taken to provide and examine the required linear scalable plasma sources. The effectiveness of close-proximity direct and remote plasma sources are demonstrated using thin film deposition of Al2O3 and ZrO2. Paper received the Hans Pulker Award for the best conference paper.
Part II. The Prognostic Significance of Stromal Eosinophilia in Head and Neck Cancer (1987)

The pathologies of 82 head and neck tumors were examined for histologic features suggestive of poor prognoses. Twelve descriptive histopathologic variables, including two grading scales for malignant tumors, were correlated with DNA flow cytometric data and clinical outcome. We found no correlation between the grading scales and DNA flow cytometric data or clinical outcome. Only one of the histopathologic variables--stromal eosinophilia--was found to significantly correlate with favorable outcome (p = .018). Stromal eosinophilia may be an important new prognostic indicator for head and neck cancer.
Multifunctional Superelastic Cellulose Nanofibrils Aerogel by Dual Ice‐Templating Assembly (2021)

Abstract A superelastic aerogel with fast shape recovery performance from large compressive strain is highly desired for numerous applications such as thermal insulation in clothing, high‐sensitive sensors, and oil contaminant removal. Fabrication of superelastic cellulose nanofibrils (CNF) aerogels is challenging as the CNF can assemble into non‐elastic sheet‐like cell walls. Here, a dual ice‐templating assembly (DITA) strategy is proposed that can control the assembly of CNF into sub‐micrometer fibers by extremely low temperature freezing (–196 °C), which can further assemble into an elastic aerogel with interconnected sub‐micron fibers by freezer freezing (−20 °C) and freeze drying. The CNF aerogel from the DITA process demonstrates isotropic superelastic behavior that can recover from over 80% compressive strain along both longitudinal and cross‐sectional directions, even in an extremely cold liquid nitrogen environment. The elastic CNF aerogel can be easily modified by chemical vapor deposition of organosilane, demonstrating superhydrophobicity (164° water contact angle), high liquid absorption (489 g g −1 of chloroform absorption capacity), self‐cleaning, thermal insulating (0.023 W (mK) −1 ), and infrared shielding properties. This new DITA strategy provides a facile design of superelastic aerogels from bio‐based nanomaterials, and the derived high performance multifunctional elastic aerogel is expected to be useful for a wide‐range of applications.
Untersuchungen an hochsubstituierten Äthylenen und Glykolen, XI1) Aufbau und Struktur von tetrasubstituierten Äthanen (1970)

Abstract Jeweils ein kristallines Diastereomeres der Verbindungen 2 und 8 ‐ 12 wird auf neuem Wege dargestellt. Ferner wird das ölige Pregnendion‐Analogon 21 durch Rupe‐Umlagerung von 14 aufgebaut.
Dr. Roger Guerra-García (1933-2020). Roger Guerra-García en la Grandes Alturas (2020)

El Dr. Roger Guerra-García en horas de la tarde de un 11 de agosto de 2020 se ha alejado físicamente de la vida terrenal para dejar perennizado su mensaje de amor al prójimo; falleció dejando como legado sus grandes enseñanzas de cuales numerosas promociones de estudiantes del pregrado y postgrado entre los que me cuento fuimos sus discípulos. El Dr. Roger Guerra-García se recibió en el año 1959 de médico-cirujano en la Facultad de Medicina de la Universidad Nacional Mayor de San Marcos (UNMSM).
Évolution contrastée des gènes eIF4E : conservation chez A. thaliana versus sélection chez le piment (exercée par les virus à ARN ?) (2007)

National audience
Supplementary Figure 1 from CBS9106-Induced CRM1 Degradation Is Mediated by Cullin Ring Ligase Activity and the Neddylation Pathway (2023)

&lt;p&gt;Supplementary Figure 1: CBS9106 reduces CRM1 protein levels through neddylation -mediated degradation in MM.1S cells. (A) MM.1S cells are treated with CBS9106 (50 nM) and/or MLN4924 (100 nM) for indicated period (0-8 hours). (B) Cells are treated with increasing concentrations of MLN4924 (0, 10, 20, 50, or 100 nM) and/or CBS9106 (50 nM) for 24 hours. (A, B) Protein levels of CRM1, CyclinB1, CulNEDD8, p53, PARP, p27, CDT1, and beta-actin are determined by western blot analysis. The measured band density was normalized relative to that of the control sample, with the control value set to 1. MM.1S cells was kindly provided by Dr. H. Yasui (University of tokyo, Tokyo, Japan). Cleaved PARP:clPARP.&lt;/p&gt;
Cocaine Abstinence and Reduced Use Associated With Lowered Marker of Endothelial Dysfunction in African Americans (2015)

The findings of this study revealed a possible association of cocaine abstinence/reduction with lowered ET levels, which suggests that such changes in cocaine use might be beneficial for preventing endothelial damage. Further studies should be conducted to investigate whether ET-1 could be used as a marker for cocaine abstinence and reduction in cocaine use.
SOLUBLE HLA ANTIGENS AND ELISA—A NEW TECHNOLOGY FOR CROSSMATCH TESTING1 (1995)

A soluble HLA ELISA for the detection of donor specific anti-HLA class I IgG antibodies was developed and compared with microlymphocytotoxicity. Donor sHLA was prepared from donor blood or purified blood lymphocytes and captured onto monoclonal antibody coated ELISA plates. After incubation of captured HLA with test serum, bound IgG antibodies were detected using a peroxidase-conjugated anti-human IgG antibody. Serum samples from patients on waiting lists to receive kidney transplants were tested by lymphocytotoxicity (AHG protocol) and/or sHLA ELISA in four different laboratories using HLA preparations from eight organ donors. Concordant crossmatch results were obtained for 854 (99%) of 864 ELISA crossmatches. In contrast, concordant results were obtained for 234 (91%) of 256 lymphocytotoxicity crossmatches. Interlaboratory reproducibility of ELISA results was 99%. In contrast, interlaboratory reproducibility of lymphocytotoxicity assay results was 78%. Endpoint titrations of serum specimens containing anti-HLA antibodies demonstrated equivalent sensitivity of ELISA and AHG lymphocytotoxicity crossmatch and similar sensitivity of ELISA and flow cytometry crossmatch. Specimens tested positive by lymphocytotoxicity without DTT treatment but negative with DTT treatment were tested negative by ELISA. Comparison of lymphocytotoxicity and ELISA crossmatch results showed an agreement of 94%. This demonstrates that detection of anti-donor HLA class I antibodies by ELISA is a reliable alternative to microlymphocytotoxicity testing.
Shape Memory Polyurethanes from Renewable Polyols Obtained by ATMET Polymerization of Glyceryl Triundec‐10‐enoate and 10‐Undecenol (2011)

Abstract The synthesis of branched polyols from glyceryl triundec‐10‐enoate by acyclic triene metathesis polymerization (ATMET) is reported. 10‐Undecenol is used as a monofunctional comonomer to end‐cap polymer chains, functionalize the periphery of the resulting branched materials, and to control the molecular weight. The thus obtained castor oil derived polyols are reacted with 4,4′‐methylenebis(phenylisocyanate) (MDI) to yield a series of semicrystalline polyurethane networks. The investigation of the thermal stability and the thermomechanical and mechanical properties of these thermosets revealed good shape memory properties. magnified image
Coffee Consumption and Type 2 Diabetes Mellitus (2004)

Letters17 August 2004Coffee Consumption and Type 2 Diabetes MellitusFrank B. Hu, MD, PhD, Walter C. Willett, MD, DrPH, and JoAnn E. Manson, MD, DrPHFrank B. Hu, MD, PhDFrom Harvard School of Public Health and Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115.Search for more papers by this author, Walter C. Willett, MD, DrPHFrom Harvard School of Public Health and Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115.Search for more papers by this author, and JoAnn E. Manson, MD, DrPHFrom Harvard School of Public Health and Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-4-200408170-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Louria asked whether nut consumption confounded the inverse association between coffee consumption and type 2 diabetes mellitus in our study. We reran the analyses controlling for nut intake; the results remained virtually unchanged, suggesting that this confounding is unlikely to explain our findings.Dr. Schaefer also raised the issue of confounding by other dietary and lifestyle factors. However, coffee consumption tends to be associated with smoking, unhealthy diet, and less exercise. Thus, such confounding would have biased the relationship between coffee consumption and type 2 diabetes mellitus toward a positive association. In an ecological analysis, Dr. Schaefer ... Author, Article, and Disclosure InformationAffiliations: From Harvard School of Public Health and Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCoffee Consumption and Risk for Type 2 Diabetes Mellitus Eduardo Salazar-Martinez , Walter C. Willett , Alberto Ascherio , JoAnn E. Manson , Michael F. Leitzmann , Meir J. Stampfer , and Frank B. Hu Coffee Consumption and Type 2 Diabetes Mellitus Donald B. Louria Coffee Consumption and Type 2 Diabetes Mellitus Benjamin Schaefer Coffee Consumption and Type 2 Diabetes Mellitus Federico Soriguer , Gemma Rojo-Martínez , and Isabel Esteva de Antonio Coffee Consumption and Type 2 Diabetes Mellitus John H. Glaser and Sheila K. Glaser Coffee Consumption and Type 2 Diabetes Mellitus Donald A. Gerber Metrics 17 August 2004Volume 141, Issue 4Page: 323-324KeywordsCoffeeExerciseFactor analysisFoodGlucoseGlucose intoleranceInsulinMilkOral glucose tolerance testType 2 diabetes ePublished: 17 August 2004 Issue Published: 17 August 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Latent volumetric structure of the human brain: Exploratory factor analysis and structural equation modeling of gray matter volumes in healthy children and adults (2007)

Previous studies have investigated patterns of volumetric covariance (i.e. intercorrelation) among brain regions. Methodological issues, however, have limited the validity and generalizability of findings from these prior studies. Additionally, patterns of volumetric covariance have often been assumed to reflect the presence of structural networks, but this assumption has never been tested formally. We identified patterns of volumetric covariance, correlated these patterns with behavioral measures, and tested the hypothesis that the observed patterns of covariance reflect the presence of underlying networks. Specifically, we performed factor analysis on regional brain volumes of 99 healthy children and adults, and we correlated factor scores with scores on the Stroop Word-Color Interference Test. We identified four latent volumetric systems in each hemisphere: dorsal cortical, limbic, posterior, and basal ganglia. The positive correlation of the right posterior system with Stroop scores suggested that larger latent volumes are detrimental to inhibitory control. We also applied Structural Equation Modeling (SEM) to our dataset (n = 107) to test whether a model based on the anatomical pathways within cortico-striatal-thalamic-cortical (CSTC) circuits accounts for the covariances observed in our sample. The degree to which SEM predicted volumetric covariance in the CSTC circuit depended on whether we controlled for age and whole brain volume in the analyses. Removing the effects of age worsened the fit of the model, pointing to a possible developmental component in establishing connections within CSTC circuits. These modeling techniques may prove useful in the future for the study of structural networks in disease populations.
Probing an extended region ofΔm2with rapidly oscillating7Besolar neutrinos (2002)

If ${}^{7}\mathrm{Be}$ solar neutrinos can be observed in real time experiments, then an extended region of $\ensuremath{\Delta}{m}^{2}$ can be probed by a proper analysis of the rapidly changing phase of vacuum oscillations due to the eccentricity of the Earth's orbit about the Sun. For the case of maximal vacuum mixing, a kind of Fourier analysis of expected data for one year's time could uniquely pick out $\ensuremath{\Delta}{m}^{2}$ if it lies in the region $\ensuremath{\sim}{10}^{\ensuremath{-}10}--(6\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}9}){(\mathrm{eV})}^{2}.$
Extra-terrestrial nuclear power stations : transportation and operation (2005)

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 2005.