gebhart/patrepeval huggingface dataset:
Effect of Young Age on Outcomes in Pediatric Acute Promyelocytic Leukemia (APL): North American Intergroup Study CALGB 9710 (Alliance) (2014)

Abstract Purpose: Clinical trials in APL have generally reported similar outcomes for children and adults. However, sub-group analysis of pediatric patients treated on 2 consecutive trials of the European APL group demonstrated that children &lt;5 years (yr) had an increased risk of relapse (Bally et al., JCO, 2012). Here we report the effect of age &lt; 5 yr on outcome for the North American Intergroup Study C9710. Methods: Outcomes were compared among young children (age &lt;5 yr, n=16) to those of older age (5-12 yr, n=25 and 13-18 yr, n=45) enrolled on C9710. Treatment on C9710 included induction with daunorubicin, cytarabine and ATRA followed by two consolidation cycles with daunorubicin and ATRA and maintenance for one year with ATRA +/- mercaptopurine and methotrexate. Patients of age ≥15 yr were randomized to receive or not receive two 5-week cycles of arsenic trioxide (ATO) before the chemotherapy consolidation. However, analysis in this study of young children compared to those of older age was restricted to patients who did not receive ATO. Results: Clinical remission (CR) rates were similar between the 3 age groups (age &lt;5 yr= 88%, age 5-12 yr= 80%, age 13-18 yr= 82%; P=0.93). Overall survival (OS) Kaplan-Meier estimates were not significantly different (log rank P=0.84), and 5 yr OS rates were 77% (age &lt;5 yr), 80% (age 5-12 yr), and 84% (age 13-18 yr). Similarly, event-free survival (EFS) Kaplan-Meier estimates were not significantly different (log rank P=0.48), and 5 yr EFS rates were 56% (age &lt;5 yr), 47% (age 5-12 yr), and 59% (age 13-18 yr). Young children did not have a higher relapse rate (5-yr cumulative incidence of relapse by age: &lt;5 yr=29%, 5-12 yr=49%, 13-18 yr=29%). Conclusions: Results of this intergroup trial demonstrate that ATRA administration during induction, consolidation and maintenance leads to CR rates &gt;80% and 5 yr OS rates &gt;75%. These results are superior to recently published results of pediatric non-APL acute myeloid leukemia and confirm results from the prior APL intergroup trial (INT0129) that demonstrated that ATRA in induction and/or maintenance significantly improved outcomes for pediatric APL (Gregory et al., Ped Blood and Cancer, 2009). Our sub-group analysis showed no association of age with outcomes in children treated with this regimen. Disclosures Off Label Use: Daunorubicin- labeled for use in AML for adults and for pediatric ALL (not pediatric AML) Arsenic Trioxide- labeled for use in relapsed/refractory APL (not de novo APL) Mercaptopurine and Methotrexate- labeled for use in pediatric ALL (not APL).
STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma (2012)

Constitutive activation of STAT3 is a common feature in many solid tumors including non-small cell lung carcinoma (NSCLC). While activation of STAT3 is commonly achieved by somatic mutations to JAK2 in hematologic malignancies, similar mutations are not often found in solid tumors. Previous work has instead suggested that STAT3 activation in solid tumors is more commonly induced by hyperactive growth factor receptors or autocrine cytokine signaling. The interplay between STAT3 activation and other well-characterized oncogenic "driver" mutations in NSCLC has not been fully characterized, though constitutive STAT3 activation has been proposed to play an important role in resistance to various small-molecule therapies that target these oncogenes. In this study we demonstrate that STAT3 is constitutively activated in human NSCLC samples and in a variety of NSCLC lines independent of activating KRAS or tyrosine kinase mutations. We further show that genetic or pharmacologic inhibition of the gp130/JAK2 signaling pathway disrupts activation of STAT3. Interestingly, treatment of NSCLC cells with the JAK1/2 inhibitor ruxolitinib has no effect on cell proliferation and viability in two-dimensional culture, but inhibits growth in soft agar and xenograft assays. These data demonstrate that JAK2/STAT3 signaling operates independent of known driver mutations in NSCLC and plays critical roles in tumor cell behavior that may not be effectively inhibited by drugs that selectively target these driver mutations.
Low voltage operation of cold field emitters at elevated pressures (2004)

In this paper, We analyzed the field emission current from a tungsten tip, held constant by the feedback circuit at the relatively high current level of 96 nA. The Ar pressure was 10/sup -3/ mbar and the tip-anode spacing a few tens of microns.
Reporter Gene PET for Monitoring Survival of Transplanted Endothelial Progenitor Cells in the Rat Heart After Pretreatment with VEGF and Atorvastatin (2009)

Early survival of transplanted EPCs in the rat myocardium is prolonged by pretreatment with a combination of atorvastatin and VEGF. Reporter gene PET, by successfully quantifying the effect, is an attractive tool for monitoring stem cell survival in vivo.
Distributed-queueing request update multiple access (DQRUMA) for wireless packet (ATM) networks (2002)

In a wireless packet (ATM) network that supports an integrated mix of multimedia traffic, the channel access protocol needs to be designed such that mobiles share the limited communications bandwidth in an efficient manner: maximizing the utilization of the frequency spectrum and minimizing the delay experienced by mobiles. In this paper, we propose and study an efficient demand assignment channel access protocol, which we call distributed-queueing request update multiple access (DQRUMA). The protocol can be used for a wide range of applications and geographic distances. Mobiles need to send requests to the base station only for packets that arrive to an empty buffer. For packets that arrive to a non-empty buffer transmission requests are placed collision-free by piggybacking the requests with packet transmissions. The simulation results show that even with the "worst possible" traffic characteristics, the delay-throughput performance of DQRUMA is close to the best possible with any access protocol. In addition, explicit slot-by-slot announcement of the "transmit permissions" gives the base station a lot of control over the order in which mobiles transmit their packets.
Melanoma Impairs Mouse Heart Function Which Short‐Term Exercise Cannot Restore (2022)

The aim of this study was to investigate whether melanoma impairs intrinsic heart function in mice and whether short‐term voluntary running wheel exercise could reduce the possible negative effects. Additionally, we investigated whether changes in cell size, capillary density, calcium channel levels, metabolic enzyme activities or oxidative stress could explain the possible changes in heart function. Advanced melanoma has been shown to cause cardiac muscle wasting and influence heart function in vivo, we hypothesized that melanoma would also impair intrinsic heart function, which has not been investigated previously. We also hypothesized that voluntary short‐term exercise could reduce the effects of melanoma on cardiac function since exercise training is known to improve cardiovascular function and reduce the negative effects of some cancers. Male mice were divided into untrained tumor‐free group (control) and untrained melanoma group and trained melanoma group. The mice did voluntary running‐wheel exercise until predetermined tumor size after which their hearts were isolated. The cardiac function was measured in retrograde perfusion at a constant pressure in multiple oxygen levels using Langendorff apparatus. The molecular and tissue level markers were measured afterwards. The melanoma animals were not cachectic as indicated lack of body weight loss. The rate of pressure production, pressure amplitude and rate of pressure decline were all significantly lower in the isolated hearts of the melanoma animals as compared to tumor‐free animals. However, the heart function did not differ between the untrained and trained melanoma groups. Furthermore, there were no differences between the groups in the calcium channel levels, reactive oxygen species, catalase activity, lipid peroxidation or citrate synthase and lactate dehydrogenase activity. However, mice from both melanoma groups had significantly lower superoxide dismutase activity as compared to tumor‐free animals, which might reduce the heart’s ability to respond to possible changes in oxidative stress. Exercise trained animals had higher capillary density, but their cell size and heart weights did not significantly differ from the untrained groups. Running wheel exercise did not affect the final tumor growth either even though there was tendency at the beginning of the experiment that running wheel exercise could slow down the tumor growth. One reason for this could be that when melanoma proceeded, the mouse running activity reduced significantly. In conclusion, melanoma is an aggressive cancer that impairs intrinsic heart function even when no cachexia is present. The aggressiveness of melanoma also prevented the short‐term voluntary exercise from alleviating the changes caused by melanoma. Future studies should combine the training to medical cancer treatment in order to estimate whether exercise training could be beneficial as adjunct therapy in melanoma treatment.
Keynote Speaker: Reconstructing Reality: From Physical World to Virtual Environments (2023)

With increasing availability of data in various forms from images, audio, video, 3D models, motion capture, simulation results, to satellite imagery, representative samples of the various phenomena constituting the world around us bring new opportunities and research challenges. Such availability of data has led to recent advances in data-driven modeling. However, most of the existing example-based synthesis methods offer empirical models and data reconstruction that may not provide an insightful understanding of the underlying process or may be limited to a subset of observations. In this talk, I present recent advances that integrate classical model-based methods and statistical learning techniques to tackle challenging problems that have not been previously addressed. These include flow reconstruction for traffic visualization, learning heterogeneous crowd behaviors from video, simultaneous estimation of deformation and elasticity parameters from images and video, and example-based multimodal display for VR systems. These approaches offer new insights for understanding complex collective behaviors, developing better models for complex dynamical systems from captured data, delivering more effective medical diagnosis and treatment, as well as cyber-manufacturing of customized apparel. I conclude by discussing some possible future directions and challenges
ChemInform Abstract: Structure Elucidation of Submilligram Quantities of Natural Products — Application to Haliclamines G and H from the Arctic Marine Sponge Haliclona viscosa. (2013)

Abstract Two new haliclamines (I) are identified directly from the crude extract of an arctic sponge using improved chromatographic conditions and detailed knowledge about the fragmentation pattern of haliclamines.
Progesterone Receptor Isoform Ratio: A Breast Cancer Prognostic and Predictive Factor for Antiprogestin Responsiveness (2016)

The PRA/PRB ratio is a prognostic and predictive factor for antiprogestin responsiveness in breast cancer.
ANALYTICAL STUDY ON COUNTERMEASURE OF UNDERGROUND LINEAR STRUCTURE SUBJECTED TO FAULT DISPLACEMENT (2017)

トンネル等の地中構造物の断層変位に対する対策は，設計規準類に明確な規定は定められていないが，研究レベルではいくつか提案されている．本論文では，それらの対策工の様々な断層条件に対する効果を検証することを目的として，無対策・継手・免震層の3ケースに対して地盤－構造物一体3次元解析によるパラメータスタディを実施し，構造物に発生する曲げモーメント・せん断力・軸力に対して，耐震裕度が小さくなる断層変位の方向，断面力低減に効果的な対策工を比較・整理した．検討の結果，評価する断面力により，耐震裕度が小さくなる断層変位の方向が異なること，評価する断面力により，有効な対策工が異なることがわかった．
Supplemental Figure S2 from Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by Braf<sup>V600E</sup> and Pten Loss (2023)

&lt;p&gt;Supplemental Figure S2 Braf conditioned media does not induce TGFβ activation in CAFs.&lt;/p&gt;
Pre‐operative brachial plexus block compared with an identical block performed at the end of surgery: a prospective, double‐blind, randomised clinical trial (2017)

We evaluated whether pre-emptive analgesia with a pre-operative ultrasound-guided infraclavicular brachial plexus block resulted in better postoperative analgesia than an identical block performed postoperatively. Fifty-two patients undergoing fixation of a fractured radius were included. All patients received general anaesthesia with remifentanil and propofol. Patients were randomly allocated into two groups: a pre-operative block or a postoperative block with 0.5 ml.kg<sup>-1</sup> ropivacaine 0.75%. After surgery, all patients received regular paracetamol plus opioids for breakthrough pain. Mean (SD) time to first rescue analgesic after emergence from general anaesthesia was 544 (217) min in the pre-operative block group compared with 343 (316) min in the postoperative block group (p = 0.015). Postoperative pain scores were higher and more patients required rescue analgesia during the first 4 h after surgery in the postoperative block group. There were no significant differences in plasma stress mediators between the groups. Analgesic consumption was lower at day seven in the pre-operative block group. Pain was described as very strong at block resolution in 27 (63%) patients and 26 (76%) had episodes of mild pain after 6 months. We conclude that a pre-operative ultrasound-guided infraclavicular brachial plexus block provides longer and better analgesia in the acute postoperative period compared with an identical postoperative block in patients undergoing surgery for fractured radius.
Microfabrication of colloidal scanning probes with controllable tip radii of curvature (2009)

We report the first batch-fabrication method to create colloidal scanning probes based on standard micromachining processes. Microfabrication of colloidal probe arrays having smooth surface profiles with radius of curvature ranging from nanometers to tens of microns is successfully demonstrated. A new mold filling technology is developed where bulk-etched cavities with sharp endpoints are transformed into cavities with curved endings via spin coating of a liquid filling material (photoresist). The curved profile is then replicated into a stable metallic mold by evaporating a layer of aluminum, after which mold-transfer scanning probe (SP) fabrication is conducted to create colloidal probes. Multiple control knobs were developed and characterized for accurate control of the tip radius of curvature. By adjusting the solid content of the filling material, the number of spin-coat cycles, and the cavity geometry, different mold profiles and thereby tip radii of curvature were achieved. The new controllable technology allows rapid microfabrication of singular or arrayed colloidal scanning probes with different tip radii of curvature which will be useful for many biological and nanotechnology applications.
Aza‐Henry Reactions of 3,4‐Dihydroisoquinoline (2010)

Abstract The aza‐Henry reaction of 3,4‐dihydroisoquinoline is reported. The reaction is favourable in excess nitromethane under ambient conditions. Isolation of the unstable reaction product is achieved by acylation or alkylation, allowing the synthesis of Reissert‐like compounds in good yields from a one‐pot, three‐component coupling. The rates of reaction for dihydroisoquinoline and the corresponding benzylisoquinolinium ion have been investigated in the presence and absence of base. The reaction with dihydroisoquinoline probably proceeds via an azinic acid tautomer of nitromethane, a reaction pathway unavailable to the isoquinolinium ion. The traditionally problematic reduction of two of the resulting β‐nitroamine derivatives was achieved, providing access to a number of new chiral vicinal diamines.
LRET-Based HTS of a Small-Compound Library for Inhibitors of Bacterial RNA Polymerase (2007)

Resistance mechanisms against whole classes of antibiotics are currently developing faster than research generates new structurally different biologically active agents. The demand for new antimicrobial drugs has not been matched by the speed of discovery. The interface between sigma and core of bacterial RNA polymerase offers an attractive target for drug discovery, and we have previously described the development of a very robust high-throughput assay for this target based on luminescence resonance energy transfer. Here we describe a semiautomated screen of a commercially available library (Chembridge, San Diego, CA) that led to the identification of four small molecules, two of which have activity in preventing in vitro transcription and growth of Escherichia coli.
Application of heparin to chiral separations of antihistamines by capillary electrophoresis (1998)

A study of the chiral separations of antihistamines, including pheniramine, chlorpheniramine, brompheniramine, carbinoxamine and doxylamine in capillary electrophoresis (CE) was accomplished using heparin as a chiral additive (CA) and phosphate buffer as the background electrolyte. Several factors were shown to affect both the selectivity and the migration time, including concentration of heparin, concentration of buffer, and the pH. A dual mechanism involving both inclusion complexation and ionic interactions with heparin is thought to be responsible for the chiral recognition. In the pH range of 2.6-3.5 and reversed polarity, baseline resolutions were obtained using a wide range of buffer and heparin concentrations. Typically, chiral resolution was obtained within 50 min.
Tumor Necrosis Factor-α, Uterine Natural Killer Cells, and Pregnancy (2016)

Tumor Necrosis Factor-α and Pregnancy 1109and SHRSP do not warrant the discussion.Nonetheless, the data presented here are a basis for further studies.Solely, magnesium therapy and early delivery remains for these patients and there are always 2 (if not more) such patients. 13We need more options and the experiments presented here could provide at least food for thought.
ADP-ribosyl transferase and NAD glycohydrolase activities in rat liver mitochondria (1987)

ADP-ribosyl transferase and NAD glycohydrolase activities have been estimated in mitochondria in mitoplasts as well as in other submitochondrial fractions. A high activity of these two enzymes was present in mitoplasts as compared to the outer membrane preparation or intermembrane compartment. Inhibitor studies provide strong evidence for the involvement of ADP-ribosyl transferase in the process of ADP-ribosylation of mitochondrial proteins. When NAD glycohydrolase was blocked by nicotinamide or 3-aminobenzamide, the incorporation of ADP-ribose into mitochondrial proteins still occurs. ADP-ribosyl transferase activity could also be detected when NAD glycohydrolase was separated by hydroxylapatite chromatography. The protein-linked ADP-ribose moiety appears to be an oligomer in mitochondria.
Hematopoietic Expression of Oncogenic BRAF Promotes Aberrant Growth of Monocyte-Lineage Cells Resistant to PLX4720 (2013)

This study supports the development of pathway-targeted therapeutics in the treatment of BRAF(V600E)-expressing hematopoietic neoplasms in the monocyte/histiocyte lineage.
Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle (2021)

The cavin proteins are essential for caveola biogenesis and function. Here, we identify a role for the muscle-specific component, Cavin4, in skeletal muscle T-tubule development by analyzing two vertebrate systems, mouse and zebrafish. In both models, Cavin4 localized to T-tubules, and loss of Cavin4 resulted in aberrant T-tubule maturation. In zebrafish, which possess duplicated cavin4 paralogs, Cavin4b was shown to directly interact with the T-tubule-associated BAR domain protein Bin1. Loss of both Cavin4a and Cavin4b caused aberrant accumulation of interconnected caveolae within the T-tubules, a fragmented T-tubule network enriched in Caveolin-3, and an impaired Ca2+ response upon mechanical stimulation. We propose a role for Cavin4 in remodeling the T-tubule membrane early in development by recycling caveolar components from the T-tubule to the sarcolemma. This generates a stable T-tubule domain lacking caveolae that is essential for T-tubule function.
Development of dry control technology for emissions of mercury in flue gas (1995)

In flue gases from coal-combustion systems, mercury in either the elemental state or its chloride form (HgCl{sub 2}) can be predominant among all the possible mercury species present; this predominance largely depends on the chlorine-to-mercury ratio in the coal feeds. Conventional flue-gas cleanup technologies are moderately effective in controlling HgCl{sub 2} but are very poor at controlling elemental mercury. Experiments were conducted on the removal of elemental mercury vapor by means of a number of different types of sorbents, using a fixed-bed adsorption system. Of the four commercial activated carbons evaluated, the sulfur-treated carbon sample gives the best removal performance, with good mercury-sorption capacities. Promising removal results also have been obtained with low-cost minerals after chemical treatments. These inorganic sorbents could potentially be developed into a cost-effective alternative to activated carbons for mercury removal.
Purification and characterization of a novel dipeptidase from carp ordinary muscle. (1998)

A novel dipeptidase was purified to homogeneity from the crude extract of carp ordinary muscle with an increase in specific activity of 4041-fold and a 4% recovery rate. The enzyme was determined to have molecular weights of 54,000 after reduction and 106,000 without reduction, indicating that it is composed of two sulfide-linking molecules of subunit peptide chains of identical molar size. The optimum hydrolysis pH and temperature of the enzyme were evaluated by l-leucine-glycine to be pH 8.5 and 40 degreesC, respectively, and it was markedly stable in the weak alkaline region and at temperatures below 30 degreesC. Dipeptide hydrolysis of the enzyme was inhibited by metalloprotease inhibitors, sulfide-specific reagents, metal chelating reagents and reductants. In addition, sulfide-affinity bivalent metals potently inactivated the enzyme, while Mg2+ and Mn2+ activated it to different extents, and Mn2+ was also effective on the restoration of the nearly completely inactivated enzyme. The enzyme had a broad range of action on dipeptides that are composed of only l-amino acids, such as l-leucine, l-methionine, l-phenylalanine, and l-valine at the C-terminal and l-alanine, l-leucine, l-methionine, and l-valine at the N-terminal, but it had no catalytic action on dipeptides containing l-proline and d-amino acids, tripeptides, and peptide derivatives.