gebhart/patrepeval huggingface dataset:
Light Water Reactor Sustainability Program Integrated Program Plan (2012)

Nuclear power has safely, reliably, and economically contributed almost 20% of electrical generation in the United States over the past two decades. It remains the single largest contributor (more than 70%) of non-greenhouse-gas-emitting electric power generation in the United States. Domestic demand for electrical energy is expected to experience a 31% growth from 2009 to 2035. At the same time, most of the currently operating nuclear power plants will begin reaching the end of their initial 20-year extension to their original 40-year operating license for a total of 60 years of operation. Figure E-1 shows projected nuclear energy contribution to the domestic generating capacity. If current operating nuclear power plants do not operate beyond 60 years, the total fraction of generated electrical energy from nuclear power will begin to decline - even with the expected addition of new nuclear generating capacity. The oldest commercial plants in the United States reached their 40th anniversary in 2009. The U.S. Department of Energy Office of Nuclear Energy's Research and Development Roadmap (Nuclear Energy Roadmap) organizes its activities around four objectives that ensure nuclear energy remains a compelling and viable energy option for the United States. The four objectives are as follows: (1) develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current reactors; (2) develop improvements in the affordability of new reactors to enable nuclear energy to help meet the Administration's energy security and climate change goals; (3) develop sustainable nuclear fuel cycles; and (4) understand and minimize the risks of nuclear proliferation and terrorism. The Light Water Reactor Sustainability (LWRS) Program is the primary programmatic activity that addresses Objective 1. This document summarizes the LWRS Program's plans.
Conducting polymer‐based flexible supercapacitor (2014)

Abstract Flexible supercapacitors, a state‐of‐the‐art material, have emerged with the potential to enable major advances in for cutting‐edge electronic applications. Flexible supercapacitors are governed by the fundamentals standard for the conventional capacitors but provide high flexibility, high charge storage and low resistance of electro active materials to achieve high capacitance performance. Conducting polymers ( CP s) are among the most potential pseudocapacitor materials for the foundation of flexible supercapacitors, motivating the existing energy storage devices toward the future advanced flexible electronic applications due to their high redox active‐specific capacitance and inherent elastic polymeric nature. This review focuses on different types of CP s‐based supercapacitor, the relevant fabrication methods and designing concepts. It describes recent developments and remaining challenges in this field, and its impact on the future direction of flexible supercapacitor materials and relevant device fabrications.
Pro RESTful APIs (2017)

Discover the RESTful technologies, including REST, JSON, XML, JAX-RS web services, SOAP and more, for building today's microservices, big data applications, and web service applications. This book is based on a course the Oracle-based author is teaching for UC Santa Cruz Silicon Valley which covers architecture, design best practices and coding labs. Pro RESTful APIs: Design gives you all the fundamentals from the top down: from the top (architecture) through the middle (design) to the bottom (coding). This book is a must have for any microservices or web services developer building applications and services. You will: Discover the key RESTful APIs, including REST, JSON, XML, JAX-RS, SOAP and more Use these for web services and data exchange, especially in today's big data context Harness XML, JSON, REST, and JAX-RS in examples and case studies &lt;apply best=" practices=" to=" your=" solutionsâ=" architecture .
The Forced-Commutated Inverter as a Regenerative Rectifier (1978)

The application of a three-phase 120°-gated forced commutated thyristor inverter as a regenerative rectification circuit is discussed. The circuit has the ability to accept or deliver dc current without change of nominal dc voltage magnitude or polarity and also has the capability to instantaneously change from ``motoring'' to ``generating'' and vice versa. An analysis of the circuit is undertaken to provide both the current waveforms and the regulation characteristic, which are compared with those of a conventional rectifier. Theoretical results are compared with those obtained from a laboratory working prototype.
Drosophila Glucosylceramide Synthase (2004)

Glucosylceramide synthase (GlcT-1) catalyzes the formation of glucosylceramide (GlcCer), the core structure of major glycosphingolipids (GSLs), from ceramide and UDP-glucose. Ceramide and its metabolites, such as sphingosine-1-phosphate, are now known to be important mediators of apoptosis and cell survival. Recently, we have shown that GlcT-1 functions to regulate intracellular ceramide levels via glycosylation of ceramide. In this study, we employ the fruit fly Drosophila melanogaster as a model system for understanding the in vivo roles of GlcT-1. We isolated and characterized a GlcT-1 homologue (DGlcT-1) from Drosophila. When DGlcT-1 was expressed in GM-95 cells deficient in GSLs (because of the absence of GlcT-1 activity), these cells regained the ability to synthesize GSLs. Northern blot and in situ hybridization analyses revealed that the expression of DGlcT-1 mRNA was ubiquitous throughout development, suggesting that DGlcT-1 is important for development and differentiation. Indeed, RNA interference experiments demonstrated that the loss of GlcT-1 function enhances apoptotic cell death. Conversely, targeted expression of GlcT-1 partially rescued cell death caused by the proapoptotic factors Reaper and Grim, suggesting that ceramide generation might be one signal pathway that executes the cell death program. We also found that GlcT-1 localized not only in the Golgi apparatus but also in the perinuclear endoplasmic reticulum, providing the first visual evidence of GlcT-1 in membranes. These results indicate that GlcT-1 might down-regulate ceramide generated in these membranes.
HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF THE STABILIZED CYCLOPHOSPHAMIDE METABOLITE 4-HYDROXYCYCLOPHOSPHAMIDE IN PLASMA AND RED BLOOD CELLS (2000)

A reversed-phase high performance liquid chromatographic (HPLC) method for the determination of the activated cyclophosphamide (CP) metabolite 4-hydroxycyclophosphamide (4-OHCP) in human plasma and red blood cells is described. 4-OHCP is very unstable in biological matrices. Therefore, it was treated, immediately after sampling, with semicarbazide to form a stable semicarbazone derivative, which was identified with electron spray mass spectrometry. The derivative was analysed with HPLC with ultraviolet (UV) detection at 230 nm. Sample pre-treatment consisted of a liquid-liquid extraction with ethyl acetate, the chromatography system was a 25 cm C8 column (particle size 5 μm) with a mobile phase of acetonitrile-0.025 M potassium phosphate buffer (15:85 v/v) pH 6.0. After assay optimisation, the method was validated and stability studies were carried out. The method proved linear in clinically relevant concentrations (50-5000 ng/mL). The lower limit of quantitation was 50 ng/mL. Accuracy and precision were below 7% over the full concentration range. A calibration curve in plasma can also be used for the quantification of 4-OHCP in red blood cells. The derivative was found to be stable for at least 11 months when stored at −70 °C. A pharmacokinetic pilot study in a patient treated with 1000 mg/m2 CP in combination with thioTEPA and carboplatin demonstrated the applicability of the assay for the determination of 4-OHCP in plasma and red blood cells.
LDPC Soft Decoding with Reduced Power and Latency in 1X-2X NAND Flash-Based Solid State Drives (2015)

The reliability of the non-volatile NAND flash memories, measured in terms of Raw Bit Error Rate (RBER), is reaching critical levels for traditional error detection and correction. Therefore, to ensure data trustworthiness in nowadays NAND flash-based Solid State Drives, it becomes essential exploiting powerful correction algorithms such as the Low Density Parity Check (LDPC). However, the burdens of this approach materialize in an increased NAND flash power consumption due to the increased memory read latencies that translates in limited disk performance. In this work it is performed a comparison between a standard LDPC decoding approach based on hard and soft decisions and an optimized solution called LDPC NAND- Assisted Soft Decision. The simulation results on 2X, 1X and mid-1X MLC NAND flash-based Solid State Drives in terms of NAND flash I/O power consumption, disk read latencies and performance, favor the adoption of the presented solution.
(Nb, Ti)3Sn Superconducting Magnet Operated at 11 K in Vacuum Using High-Tc (Bi, Pb)2Sr2Ca2Cu3O10 Current Leads (1993)

A conduction-cooled superconducting magnet using high- T c oxide current leads was successfully demonstrated. We succeeded in constructing the (Nb, Ti) 3 Sn multifilamentary superconducting magnet system without liquid helium, which is operated at 11 K in vacuum using a cryocooler and generates a magnetic field of 4.6 T in a 50 mm bore (38 mm room temperature bore). Use of (Bi, Pb) 2 Sr 2 Ca 2 Cu 3 O 10 current leads effectively contributed to realization of the compact cryostat with large current leads of 500 A.
Ultrasound Phantom Using Thin Wires for the Depiction of Calcification -Comparison of Cross-Sections of Wire Targets and Mass Targets- (2011)

We report on a technique to construct an ultrasound calcification phantom using wires. Employment of the proper angle of the measurement plane to a wire target can adjust its effective size to that of a mass target. To acquire this angle of the measurement plane we compared the scattering cross-sections of 0.2, 0.1, 0.05 and 0.03 mm diameter copper wires, and copper cylinders that are 0.2 and 0.1 mm in size. The experiments were conducted using a commercial ultrasonographic device with a 7.5 MHz linear array probe. The scattering cross-section of a wire is severely reduced as the angle of the measurement plane to that wire decreases. At a depth of 2 cm the scattering cross-sections of the 0.2 and 0.1 mm copper cylinders are equivalent to the scattering cross-section of a 0.1 mm diameter copper wire, when the measurement plane angles to the wire are 87.6 and 87.0 degrees for the 0.2 and 0.1 mm copper cylinders, respectively. This result indicated that the employment of the proper angle of the measurement plane can adjust the effective size of a wire target to the size of a mass target, and consequently fulfills the requirements for use as a calcification phantom.
Rabbit antithymocyte globulin–induced serum sickness disease and human kidney graft survival (2015)

This study was funded by Société d'Accélération du Transfert de Technologies Ouest Valorisation, the European FP7 "Translink" research program, the French National Agency of Research, Labex Transplantex, the Natural Science and Engineering Research Council of Canada, and the Canadian Foundation for Innovation.
Artichoke plume moth: Chemical control now possible if applications of proper chemicals are correctly timed (1951)

Commercial production of the globe artichoke is limited to several coastal counties–San Mateo, Santa Cruz, Monterey, San Luis Obispo, and Santa Barbara–where approximately 8,000 acres are grown.
Quantitative Analysis of Aspirin, Phenacetin, and Caffeine Mixtures by Nuclear Magnetic Resonance Spectrometry. (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative Analysis of Aspirin, Phenacetin, and Caffeine Mixtures by Nuclear Magnetic Resonance Spectrometry.D. P. HollisCite this: Anal. Chem. 1963, 35, 11, 1682–1684Publication Date (Print):October 1, 1963Publication History Published online1 May 2002Published inissue 1 October 1963https://pubs.acs.org/doi/10.1021/ac60204a043https://doi.org/10.1021/ac60204a043research-articleACS PublicationsRequest reuse permissionsArticle Views1952Altmetric-Citations108LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Master Curve Establishment and Complex Modulus Evaluation of SBS-Modified Asphalt Mixture Reinforced with Basalt Fiber Based on Generalized Sigmoidal Model (2020)

Basalt fiber has been proved to be a good modified material for asphalt mixture. The performance of basalt fiber modified asphalt mixture has been widely investigated by extensive researches. However, most studies focused on ordinary static load tests, and less attention was paid to the dynamic mechanical response of asphalt mixture incorporating with basalt fiber. This paper aims to establish the master curve of complex modulus of asphalt mixture incorporating of styrene-butadiene-styrene (SBS) polymer and basalt fiber using the generalized Sigmoidal model. Both loading frequency and temperature were investigated for dynamic mechanical response of asphalt mixture with basalt fiber. In addition, based on the time-temperature superposition principle, the master curves of complex modulus were constructed to reflect the dynamic mechanical response at an extended reduced frequency range at an arbitrary temperature. Results indicated that the generalized Sigmoidal model in this paper could better reflect the dynamic mechanical response accurately with correlation coefficients above 0.97, which is utilized to predict the dynamic mechanical performances accurately. Simultaneously, the modulus values exhibit an increasing trend with loading frequency and decrease versus temperature. However, the phase angle values showed different trends with frequency and temperature.
Complexities of the interaction of Ni(II), Pd(II) and Pt(II) pyrrole-imine chelates with human serum albumin (2023)

Human serum albumin (HSA) efficiently transports drugs in vivo: most are organic. Here, HSA binding affinity and site specificity are shown to depend on the identity of the d8 metal ion in Ni(II), Pd(II) and Pt(II) chelates of the bis(pyrrole-imine) ligand H2PrPyrr. Fluorescence quenching data for native and probe-bound HSA showed sites close to Trp-214 (subdomain IIA) are targeted. The Stern-Volmer constants, KSV, ranged from 10^4 M^(-1) to 10^5 M^(-1) while the affinity constants, Ka, ranged from 3.5 x 10^3 M^(-1) to 1 x 10^6 M^(-1) at 37 degrees Centigrade, following the order Pd(PrPyrr) > Pt(PrPyrr) > Ni(PrPyrr) > H2PrPyrr. Ligand uptake is enthalpically driven, hinging mainly on London dispersion forces. Induced CD spectra for the protein-bound ligands could be simulated by hybrid QM:MM TD-DFT methods, proving that the metal chelates neither decompose nor demetallate after uptake by HSA. Transport and delivery of the metal chelates by HSA in vivo could therefore be feasible.
Absence of 566C >T mutation in exon 7 of the FSHR gene in Indian women with premature ovarian failure (2009)

The form of premature ovarian failure (POF) corresponding to the Mendelian Inheritance in Man (MIM) code number 311360 is defined as a cessation of menses (amenorrhea) accompanied by elevated gonadotropin levels before the age of 40 years. In this form of POF, the cause of ovarian failure is an inactivating mutation of the follicle stimulating hormone receptor (FSHR) gene. A 566CNT mutation in exon 7 of the FSHR gene, predicting an alanine to valine substitution at residue 189 of the highly-conserved extracellular ligand-binding domain of the protein, was reported in a genetic study of 6 multiplex Finnish families [1]. Although the development of secondary sexual characteristics varied for the affected female members of these families, all had hypergonadotropic hypogonadism and follicular maturation arrested between the primordial and preantral stages, and all were homozygous for the mutation. In a subsequent study, the authors showed that the 566CNT mutation in FSHR suppresses the gene's targeting of the cell membrane, probably because of alterations in the intracellular folding of the corresponding protein [2]. The authors indicated that treating individuals homozygous for the mutationwith high doses of recombinant follicle stimulating hormone did not produce functional responses of the ovaries or testes. The aim of the present study was to determine whether the 566CNT inactivating mutation of the FSHR gene was present in Indianwomenwith POF. Fiftywomenyounger than 40 years and diagnosed as having POFwere recruited at the Institute of Genetics and Hospital for Genetic Diseases, Osmania University Hyderabad and Maternal Health and Research Trust, Hyderabad, India. The study was approved by the ethics committee for biomedical research of the Institute of Genetics and Hospital for Genetic Diseases of Osmania University, Hyderabad, India. Informed consent was obtained from all participants. All study patients had their medical and gynecologichistory takenandunderwenta complete clinical examination. Age at menarche and menopause were noted, as well as maternal
Azimuthal seismic scattering analysis of fractures (2017)

Fractures play a very crucial role in reservoir characterization. Their properties not only affect the subsurface hydro-carbon distribution but also the oil recovery, well design and risk assessment. Therefore, it is paramount to characterize the fractures using a minimized amount of computation and field testing efforts. In this work, we develop an integral based numerical modeling method, which explicitly simulates fractures in terms of the displacement-discontinuity in the seismic wavefield. The fractures are explicitly modeled as linear-slip boundaries on the numerical mesh. This approach allows a comprehensive investigation of the effect of source-to-fracture azimuth, which is defined as the angle between the fractures and wave source, on the wave scattering induced by fractures. This investigation includes three different types of fractures: a single fracture, multiple parallel aligned fractures and intersecting fractures. The results in term of fracture indices show a clear trend of this source-to-fracture azimuth effect. Finally, we establish a correlation between source-to-fracture azimuth and wave scattering, which, in turn, lays the foundation for a future inversion algorithm to quantify fracture properties. Presentation Date: Wednesday, September 27, 2017 Start Time: 8:55 AM Location: 330A Presentation Type: ORAL
Evaluation of Salacia Species as Anti‐diabetic Natural Resources Based on Quantitative Analysis of Eight Sulphonium Constituents: A New Class of α‐Glucosidase Inhibitors (2014)

Two analytical protocols were successfully applied to analyse 32 Salacia samples, and revealed that sulphoniums (1-8) had characteristic distributions due to the plant part and/or due to geographical region.
Targeting estrogen receptor beta (ERβ) for treatment of ovarian cancer: importance of KDM6B and SIRT1 for ERβ expression and functionality (2018)

Estrogen receptor (ER) β has growth inhibitory and chemo drug potentiating effect on ovarian cancer cells. We studied the dependence of ERβ function on the presence of KDM6B and SIRT1 in human ovarian cancer cells in vitro. Activation of ERβ with the subtype-selective agonist KB9520 resulted in significant inhibition of human ovarian cancer cell growth. KB9520-activated ERβ had an additive effect on growth inhibition in combination with cisplatin and paclitaxel, respectively. Loss of KDM6B expression had a negative effect on ERβ function as a ligand-dependent inhibitor of ovarian cancer cell growth. In contrast, loss or inhibition of SIRT1 deacetylase activity restored ligand-activated ERβ functionality. Presented data suggest that selective targeting of ERβ with an agonist potentiate chemotherapy efficacy for the treatment of ovarian cancer and that downregulation or inhibition of SIRT1 may further enhance its therapeutic effect.
Enriched video semantic metadata: Authorization, integration, and presentation (2003)

Abstract An enriched video metadata framework including video authorization using VAST, metadata integration, and user level applications is presented. The Video Annotation and Summarization Tool (VAST) is a novel video metadata authorization system that integrates both semantic and visual metadata. Balance between accuracy and efficiency is achieved by adopting a semi‐automatic authorization approach. Semantic information such as video annotation is integrated with the visual information under a XML schema. Results from user studies and field experiments using the VAST metadata demonstrated that the enriched metadata were seamlessly incorporated into application level programs such as the Interactive Shared Educational Environment (ISEE). Given the VAST metadata, a new video surrogate called the smartlink video surrogate was proposed and deployed in the ISEE. VAST has become a key component of the emerging Open Video Digital Library toolkit.
A model‐driven approach to predicting dependability of WS‐CDL based service composition (2011)

Abstract Web Service Choreography Description Language (WS‐CDL) is a mainstream standard for the description of peer‐to‐peer collaborations for the participants of service composition. To predict the dependability of composite service processes specified in WS‐CDL allows service designers and user to decided whether the process meets the nonfunction requirements of trustworthiness, and to choose the process with better dependability to those with identical function. Unfortunately, very limited research attention is paid to dependability of WS‐CDL. In this paper, we propose a model‐driven approach for dependability prediction of composite service built on WS‐CDL. The main innovation of this research includes a complete translation from WS‐CDL to generalized stochastic Petri nets (GSPN) and a dependability (using process‐normal‐completion‐probability as the metric of dependability of service composition) calculation algorithm based on GSPN. We also validate the accuracy of the approach in the experimental study by showing 95% confidence intervals obtained from experimental dependability results that cover the corresponding theoretical prediction values. Copyright © 2011 John Wiley &amp; Sons, Ltd.