gebhart/patrepeval huggingface dataset:
A MS-Windows software tool for multimedia e-mail in local area networks (1997)

We propose a MS-Windows based software system for multimedia e-mail in a LAN like Ethernet (10Base-T), so-called 'nonguaranteed QoS LAN'. The proposed software system integrates several functions in the MS-Windows based graphical environment, such as: playing and recording of audio and video signals; speech compression/decompression by using a software implementation of the USA FED STD 1016 CELP 4800 b/s speech coding standard; video compression/decompression by using a software implementation of the ITU-T H.261 p/spl times/64 kb/s standard algorithm; and a part of the system that provides transportation of compressed or uncompressed data over the network. The system enables the sending of short uncompressed multimedia messages (in WAV and AVI formats, for example) and much longer compressed ones through the 10 Mb/s Ethernet packet service system. In the other words, a key feature of the proposed system lays in incorporating of the speech and video standard compression algorithms that enable a considerable reduction of the storage requirements of the LAN terminals and a saving of the required communication bandwidth. Also, the use of speech and video compression algorithms can improve the standardization characteristics of the entire system. The proposed system does not require special hardware modules for the audio and video compression algorithms because the compression/decompression process is based on off-line software implementations.
Application Analysis of Improved K-Means Clustering Based on Simulated Annealing-KNN (2023)

Traditional K-Means algorithm is not only strongly dependent on cluster center, but also difficult to determine the optimal cluster center. The determination of the optimal clustering center is very important for the subsequent clustering analysis. Therefore, in this paper, aiming at the key problem that K-Means algorithm is difficult to determine the clustering center, the reliability of the optimal clustering center determined by the improved K-Means algorithm based on simulated Anneal-KNN is tested by using questionnaire Star to collect data sets. The characteristic data with labels generated by k-means clustering is trained based on the simulated anneal-KNn algorithm. The simulated annealing algorithm seeks the optimal Knn parameter combination and determines the optimal K value. Input the best k value into k-means clustering, identify and screen key feature variables through the importance of predictive variables, and finally conduct cluster analysis for key feature variables. Experimental data show that the optimal k value obtained has strong reliability, and finally the contour coefficient of the clustering model reaches 0.909, which significantly improves the clustering effect compared with the single model or other models.
Human papillomavirus subtypes distribution among 2309 cervical cancer patients in West China (2017)

HPV16 and HPV18 were the most prevalent HPV subtypes among the cervical cancer patients, followed by HPV58, HPV53, and HPV33. 9.13% of the cases appeared to not be associated with HPV. This suggests that HPV testing without the use of cytology may overlook some special types of cervical cancer that account for approximately 10% of all cervical cancer cases.
A home amongst the gum trees (2012)

I am one of the approximately 70,000 ANF members who choose to live in rural or remote Australia. Whilst I commute by train to the city daily for work I escape each evening to my 'home among the gum trees'. Amidst the beauty of the countryside there are challenges, especially with access to health and aged care services. The ANF is one of the 32 national organisations in the National Rural Health Alliance, working collaboratively to improve the health and wellbeing of people in Australia's rural and remote areas. The Alliance is tireless in lobbying the Australian Government on a range of health care inequities experienced by country people, including Indigenous communities.
New methods for leak detection and contour correction in seeded region growing segmentation (2004)

Segmentation, i.e. the labelling of objects in image data, is a crucial step in many medical imaging processing tasks, e.g. operation planning, radio therapy or diagnostics. Seeded region growing is a basic yet effective method for semi-automatic segmentation. Its major drawback is that poor contrast at the organ edges may result in leaks, letting the area grow far beyond the region of interest. We developed a new method to reliably detect the origins of these leak regions and correct the segmentation results. Our approach is based on the observation that leaks are normally characterized by a narrow bottleneck connection to the seed area. We detect this bottleneck by specifying a single point somewhere within the erroneous area and tracing a path back to the seed point, moving along the skeleton of the segmented region. The point on the skeleton with the minimal distance to the contour marks the bottleneck. To cope with minor deviations from the desired result (not featuring a characteristic bottleneck), we optimized our freehand tool to minimize the necessary user interaction. Instead of separately cutting or merging parts of the segmentation, the new tool allows modifications by replacing entire parts of the contour in a single step.
A context aware handheld wayfinding system for individuals with cognitive impairments (2008)

A challenge to individuals with cognitive impairments in wayfinding is how to remain oriented, recall routines, and travel in unfamiliar areas in a way relying on limited cognitive capacity. According to psychological model of spatial navigation and the requirements of rehabilitation professionals, a novel wayfinding system is presented with an aim to increase workplace and life independence for people suffering from diseases such as traumatic brain injury, cerebral palsy, mental retardation, schizophrenia, Down syndromes, and Alzheimer's disease. This paper describes an approach to providing distributed cognition support of travel guidance for persons with cognitive disabilities. The unique strength of the system is the ability to provide unique-to-the-user prompts that are triggered by context. As this population is very sensitive to issues of abstraction (e.g. icons) and presents the designer with the need to tailor prompts to a 'universe-of-one' the use of images specific to each user and context is implemented. The key to the approach is to spread the context awareness across the system, with the context being flagged by the QR-code tags and the appropriate response being evoked by displaying the appropriate path guidance images indexed by the intersection of specific end-user and context ID embedded in the tags. By separating the context trigger from the pictorial response, responses can be updated independently of the rest of the installed system, and a single QR-code tag can trigger multiple responses in the PDA depending on the end-user and their specific path. A prototype is built and tested in field experiments with real patients. The experimental results show the human-computer interface is friendly and the capabilities of wayfinding are reliable.
Substrate Specificity of α-Galactosidase fromAspergillus niger5–16 (1991)

This paper describes the specificity of Aspergillus niger 5–16 α-galactosidase toward various oligosaccharides having terminal galactose or stub galactose or both on the oligosaccharide. The galactosidase rapidly hydrolyzed p-nitrophenyl-α-d-galactopyranoside, but hardly liberated galactose from melibiose, manninotriose, 63-α-d-galactosylmannotriose, etc. On the other hand, the enzyme tore off the stub galactoses attached to the inner mannoses of the main-chain of galactomannooligosaccharides, but not the terminal galactoses attached to the non-reducing-end mannoses of the main-chain. Thus, the substrate specificity of A. niger 5–16 α-galactosidase is quite different from that of Mortierella vinacea α-galactosidase.
Port interference faults in two-port memories (2003)

A two-port memory contains two similar ports, which can be accessed separately and independent of each other. In this paper, logical fault models are derived for the effect of shorts between the ports. The result is a set of new fault models, based on circuit simulation, together with a new test.
Wafer Bonding for Backside Illuminated Image Sensors (2012)

Backside illuminated image sensors combine small pixel area with high signal-to-noise ratio. Wafer bonding is a key enabling process step for manufacturing of backside illuminated image sensors. The fully CMOS processed image sensor wafer is bonded to a blank silicon carrier wafer and then back thinned to reveal the photodiodes. As a result the photodiodes are on top of the metal interconnects thereby eliminating any shading of the photosensitive area. Plasma activated fusion wafer bonding enables a room temperature wafer bonding with highest wafer-to-wafer alignment accuracy.
Aging response investigation of 2017 Al alloy processed by gravity and squeeze casting (2019)

International audience
Isolation and sequence analysis of dacB, which encodes a sporulation-specific penicillin-binding protein in Bacillus subtilis (1992)

A novel penicillin-binding protein (PBP 5*) with D,D-carboxypeptidase activity is synthesized by Bacillus subtilis, beginning at about stage III of sporulation. The complete gene (dacB) for this protein was cloned by immunoscreening of an expression vector library and then sequenced. The identity of dacB was verified not only by the size and cross-reactivity of its product but also by the presence of the nucleotide sequence that coded for the independently determined NH2 terminus of PBP 5*. Analysis of its complete amino acid sequence confirmed the hypothesis that this PBP is related to other active-site serine D,D-peptidases involved in bacterial cell wall metabolism. PBP 5* had the active-site domains common to all PBPs, as well as a cleavable amino-terminal signal peptide and a carboxy-terminal membrane anchor that are typical features of low-molecular-weight PBPs. Mature PBP 5* was 355 amino acids long, and its mass was calculated to be 40,057 daltons. What is unique about this PBP is that it is developmentally regulated. Analysis of the sequence provided support for the hypothesis that the sporulation specificity and mother cell-specific expression of dacB can be attributed to recognition of the gene by a sporulation-specific sigma factor. There was a good match of the putative promoter of dacB with the sequence recognized by sigma factor E (sigma E), the subunit of RNA polymerase that is responsible for early mother cell-specific gene expression during sporulation. Analysis of PBP 5* production by various spo mutants also suggested that dacB expression is on a sigma E-dependent pathway.
Effects of Defibrotide in Acute Renal Failure due to Thrombotic Microangiopathy (1986)

Thrombotic microangiopathy (TMA) can occur whenever pathogenetic events lead to fibrin deposition in the microcirculation. It has been suggested that intravascular coagulation is important in the development of renal as well as cerebral lesions. The mortality rate in adults varies from 50 to 70%; chronic or progressive renal failure occurs in approximately two thirds of children over 2 years of age. Poor success may be due to therapy being initiated too late or to inappropriate use of antagonistic drugs, or both. In the last 2 years we have treated 8 patients with TMA (5 with thrombotic thrombocytopenic purpura; 3 with hemolytic uremic syndrome) with defibrotide, a new antithrombotic agent extracted from mammalian lungs. At admission all patients had severe renal involvement (serum creatinine 5.3-14.9 mg/dl) and coagulation abnormalities (low platelet count; high levels of circulating fibrin degradation products). There were neurological manifestations in 6 patients. Defibrotide administration was followed in 6 patients by recovery of renal function. In all patients, defibrotide therapy induced the disappearance of neurological manifestations and normalization of coagulation abnormalities. Defibrotide caused no side effects. All patients are alive after 7-22 months of follow-up.
The effect of chronic duct ligation on the vascular and secretory responses of the cat's submaxillary gland (1973)

1. The object of the present experiments was to re-investigate the role of kallikrein in functional hyperaemia in the submaxillary gland of the cat. Kallikrein concentration in the gland and saliva was reduced by ligation of the duct for 2-3 days before the acute experiment, at which time the duct was cannulated proximal to the ligation and blood flow and salivation measured.2. Despite the fall in kallikrein concentration, a normal two-phase vascular response was obtained on continuous stimulation of the chorda-lingual nerve at 1-5 Hz and the progressive increase in blood flow to a constant level characteristic of 10 and 20 Hz stimulation was also seen. Quantitatively, the increase in blood flow following a 10 sec stimulation was reduced to about 75% of control values at all stimulation frequencies used and the maintained vasodilatation was reduced when using continuous stimulation at 1 Hz but not at 10 and 20 Hz.3. The supersensitivity to the vasodilator properties of bradykinin, previously reported to follow duct ligation, was confirmed.4. The increased blood flow produced by chorda-lingual nerve stimulation could be delayed by circulatory arrest. Evidence was obtained suggesting that the vascular response to chorda stimulation delayed by arterial occlusion was not mediated by kallikrein alone.5. It was concluded that kallikrein was not the sole mediator of functional hyperaemia in the cat submaxillary gland but that a combination of vasodilator nerves and kallikrein release explained more phenomena than either hypothesis alone.
Towards robust personal assistant robots: Experience gained in the SRS project (2012)

SRS is a European research project for building robust personal assistant robots using ROS (Robotic Operating System) and Care-O-bot (COB) 3 as the initial demonstration platform. In this paper, experience gained while building the SRS system is presented. A main contribution of the paper is the SRS autonomous control framework. The framework is divided into two parts. First, it has an automatic task planner, which initialises actions on the symbolic level. The planner produces proactive robotic behaviours based on updated semantic knowledge. Second, it has an action executive for coordination actions at the level of sensing and actuation. The executive produces reactive behaviours in well-defined domains. The two parts are integrated by fuzzy logic based symbolic grounding. As a whole, they represent the framework for autonomous control. Based on the framework, several new components and user interfaces are integrated on top of COB's existing capabilities to enable robust fetch and carry in unstructured environments. The implementation strategy and results are discussed at the end of the paper.
5 Jahre Institut für Solarforschung (2016)

Übersicht über die Entwicklung des Instituts für Solarforschung seit Gründung vor 5 jahren
Intraoperative ultrasonography in detection of hepatic metastases from colorectal cancer (1995)

Intraoperative ultrasonography reduces the number of patients with liver metastases from being subjected to superfluous or even harmful liver surgery, and it may increase the number in whom liver surgery will prolong life.
Numerical nonisothermal flow analysis of non‐Newtonian fluid in a nonintermeshing counter‐rotating twin screw extruder (1994)

Abstract A simulation technique for nonisothermal flow analysis of non‐Newtonian fluid in a nonintermeshing counter‐rotating twin screw extruder was developed by modifying the flow analysis network (FAN) method. The local shear viscosity in the flow field was calculated by an iteration method combing the three types of mean shear rate functions. The modified Cross model and an Arrhenius‐type function for temperature dependence were also introduced. Streamlines in the flow field are represented by computing the movements of fluid particles based on the flux fields. The computed residence time from the streamlines led us to solve the energy equation by replacing the coordinate system. The profiles of pressure, shear rate, shear viscosity, temperature, and residence time were simulated. The influence of operating and geometrical parameters on the screw characteristics are discussed. Further, residence time distribution (RTD), strain distribution function (SDF), and interfacial area growth are predicted from the computation of streamlines to analyze the mixing capabilities of the extruder.
Supplementary Data from Tumor Expression Quantitative Trait Methylation Screening Reveals Distinct CpG Panels for Deconvolving Cancer Immune Signatures (2023)

Supplementary Data from Tumor Expression Quantitative Trait Methylation Screening Reveals Distinct CpG Panels for Deconvolving Cancer Immune Signatures
Gadolinium Chloride Attenuates Sepsis-Induced Pulmonary Apoptosis and Acute Lung Injury (2012)

Gadolinium chloride (GdCl3), a Kupffer cells inhibitor, attenuates acute lung injury; however, the mechanisms behind this effect are not completely elucidated. We tested the hypothesis that GdCl3 acts through the inhibition of lung parenchymal cellular apoptosis. Two groups of rats were injected intraperitoneally with saline or E. coli lipopolysaccharide. In two additional groups, rats were injected with GdCl3 24 hrs prior to saline or LPS administration. At 12 hrs, lung injury, inflammation, and apoptosis were studied. Lung water content, myeloperoxidase activity, pulmonary apoptosis and mRNA levels of interleukin-1 β , -2, -5, -6, -10 and TNF- α rose significantly in LPS-injected animals. Pretreatment with GdCl3 significantly reduced LPS-induced elevation of pulmonary water content, myeloperoxidase activity, cleaved caspase-3 intensity, and attenuated pulmonary TUNEL-positive cells. GdCl3 pre-treatment upregulated IL-1 β , -2 and -10 pulmonary gene expression without significantly affecting the others. These results suggest that GdCl3 attenuates acute lung injury through its effects on pulmonary parenchymal apoptosis.
Regio- and stereospecific oxidation of fluorene, dibenzofuran, and dibenzothiophene by naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816-4 (1996)

The regio- and stereospecific oxidation of fluorene, dibenzofuran, and dibenzothiophene was examined with mutant and recombinant strains expressing naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816-4. The initial oxidation products were isolated and identified by gas chromatography-mass spectrometry and nuclear magnetic resonance spectrometry. Salicylate-induced cells of Pseudomonas sp. strain 9816/11 and isopropyl-beta-D-thiogalactopyranoside-induced cells of Escherichia coli JM109(DE3)(pDTG141) oxidized fluorene to (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene (80 to 90% relative yield; > 95% enantiomeric excess [ee]) and 9-fluorenol (< 10% yield). The same cells oxidized dibenzofuran to (1R,2S)-cis-1,2-dihydroxy-1, 2-dihydrodibenzofuran (60 to 70% yield; > 95% ee) and (3S,4R)-cis-3, 4-dihydroxy-3,4-dihydrodibenzofuran (30 to 40% yield; > 95% ee). Induced cells of both strains, as well as the purified dioxygenase, also oxidized dibenzothiophene to (+)-(1R,2S)-cis-1,2-dihydroxy-1, 2-dihydrodibenzothiophene (84 to 87% yield; > 95% ee) and dibenzothiophene sulfoxide (< 15% yield). The major reaction catalyzed by naphthalene dioxygenase with each substrate was stereospecific dihydroxylation in which the cis-dihydrodiols were of identical regiochemistry and of R configuration at the benzylic center adjacent to the bridgehead carbon atom. The regiospecific oxidation of dibenzofuran differed from that of the other substrates in that a significant amount of the minor cis-3,4-dihydrodiol regioisomer was formed. The results indicate that although the absolute stereochemistry of the cis-diene diols was the same, the nature of the bridging atom or heteroatom influenced the regiospecificity of the reactions catalyzed by naphthalene dioxygenase.
Ras Regulates NFAT3 Activity in Cardiac Myocytes (2001)

Multiple distinct signal transduction pathways have been implicated in the development of cardiac myocyte hypertrophy. These hypertrophic pathways include those regulated by the Ras superfamily of small GTPases and a separate calcineurin-regulated pathway that culminates in the activation of the transcription factor NFAT3. In this report, we demonstrate a functional interaction between Ras-regulated and calcineurin-regulated pathways. In particular, expression in neonatal myocytes of a constitutively active form of Ras (V12ras), but not activating mutants of Rac1, RhoA, or Cdc42, results in an increase in NFAT activity. Similarly, expression of an activated Ras, but not other small GTPases, results in the nuclear translocation of an NFAT3 fusion protein. Expression of a dominant negative ras gene product blocks phenylephrine-stimulated NFAT transcriptional activity and the ligand-stimulated NFAT3 nuclear localization. Ras proteins appear to function upstream of calcineurin, because cyclosporin A blocks the ability of V12ras to stimulate NFAT-dependent transcription and nuclear localization. Similarly, expression of a dominant negative ras gene inhibits phenylephrine-stimulated calcineurin activity. Pharmacological inhibition of MEK1 or expression of a dominant negative form of c-Raf or ERK2 inhibits phenylephrine-stimulated NFAT3 activation. Conversely, NFAT activity was stimulated by expression of constitutively active forms of c-Raf or MEK1. Taken together, these results imply that, in cardiac myocytes, a Ras-regulated pathway involving stimulation of mitogen-activated protein kinase regulates NFAT3 activity.