gebhart/patrepeval huggingface dataset:
Designing BEE: A Hardware Emulation Engine for Signal Processing in Low-Power Wireless Applications (2003)

This paper describes the design of a large-scale emulation engine and an application example from the field of low-power wireless devices. The primary goal of the emulator is to support design space exploration of real-time algorithms. The emulator is customized for dataflow dominant architectures, especially focusing on telecommunication-related applications. Due to its novel routing architecture and application-specific nature, the emulator is capable of real-time execution of a class of algorithms in its application space. Moreover, the dataflow structure facilitates the development of a highly abstracted design flow for the emulator. Simulations and practical measurements on commercial development boards are used to verify that real-time emulation of a low-power TDMA receiver is feasible at a clock speed of 25 MHz.
Synthetic Routes to Thiooligosaccharides and Thioglycopeptides (2005)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic Routes to Thiooligosaccharides and ThioglycopeptidesKandasamy Pachamuthu and Richard R. SchmidtView Author Information Fachbereich Chemie, Universität Konstanz, Fach M 725, D - 78457 Konstanz, Germany Cite this: Chem. Rev. 2006, 106, 1, 160–187Publication Date (Web):December 3, 2005Publication History Received1 June 2005Published online3 December 2005Published inissue 1 January 2006https://pubs.acs.org/doi/10.1021/cr040660chttps://doi.org/10.1021/cr040660cresearch-articleACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views4198Altmetric-Citations239LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbohydrates,Free radicals,Monomers,Peptides and proteins,Thiols Get e-Alerts
Wild-Type p53 Attenuates Cancer Cell Motility by Inducing Growth Differentiation Factor-15 Expression (2011)

A major function of the p53 tumor suppressor is the regulation of the cell cycle and apoptosis. In addition to its well-documented functions in malignant cancer cells, p53 can also regulate cell migration and invasion, which contribute to metastasis. Growth differentiation factor-15 (GDF-15), a member of the TGF-β superfamily, has been shown to be a downstream target of p53 and is associated with diverse human diseases and cancer progression. In this study, we examined the potential role of GDF-15 in p53-regulated cancer cell motility. We show that overexpression of wild-type p53 in two highly invasive p53-null human cancer cell lines, SKOV3 and PC3, attenuated cell migration and the movement through Matrigel. Using wild-type p53 and DNA-binding-deficient p53 mutants, we found that the transcriptional activity of p53 is required in the induction of GDF-15 expression. Cell movement through uncoated and Matrigel-coated transwell decreased in response to treatment with recombinant GDF-15, whereas the cell proliferation was not affected by GDF-15 treatment. Moreover, the induction of GDF-15 expression and secretion by p53 and the reduction in cell movement through Matrigel were diminished by treatment with GDF-15 small interfering RNA. This study demonstrates a mechanism by which p53 attenuates cancer cell motility through GDF-15 expression. In addition, our results indicate that GDF-15 mediates the functions of p53 by autocrine/paracrine action.
A mechanism of increase in the on-current and offcurrent due to a slightly smaller spacer in state-of- the-art p-channel MOS transistors during manufacturing (2006)

Our observation is that both the oncurrent and off-current of state-of- the-art pchannel MOS transistors tend to become larger when the spacer becomes smaller. In this paper, we propose 2 mechanisms involved in this on-current and offcurrent increase due to a slightly smaller spacer. Mechanism A is a decrease in the effective channel length. Because of a TED/BED (transient enhanced diffusion/boron enhanced diffusion) mechanism, the deep p-type D/S implant closer to the channel region makes the p-type D/S extension implant to diffuse farther into the channel region, resulting in a smaller effective channel length L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">eff</inf> . Mechanism B is a decrease in the series resistance. The deep ptype D/S implant moving closer into the channel region also causes a reduction in the D/S series resistance R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">series*</inf> The smaller L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">eff</inf> and R <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">series</inf> together can produce a higher on-current. The smaller Leff also causes a significant increase in off-current.
Electric-field-induced structure in polyacrylonitrile (1979)

Experimental evidence has been obtained for alteration of the molecular organization in polyacrylonitrile which has been given a thermoelectric treatment that creates a persistent electrical polarization. These studies have involved infrared spectroscopy and x-ray diffractometry, and their results have been interpreted as suggesting the existence of dipolar clusters in polarized material. These clusters cause polyacrylonitrile chains to adopt a structure which is different from any previously reported for this material. It is suggested that stability of the polarized state of polyacrylonitrile results, in part, from this new molecular organization. (Author)
Dual Architecture Uplink Demonstration of a 7×622 Mbps SAC-OCDMA PON Using a Burst-Mode Receiver (2008)

We demonstrate experimentally the uplink of an incoherent spectral amplitude-coded optical code-division multiple-access passive optical network (PON) using a burst-mode receiver. Error free transmission is achieved for local sources and centralized sources PON architectures.
Nano-Emulsions: Formation, Properties, and Applications (2002)

Nano-emulsions are a class of emulsions with uniform and extremely small droplet size (typically in the range 20-500 nm). Because of their characteristic size, some nanoemulsions appear transparent or translucent to the naked eye (resembling microemulsions) and possess stability against sedimentation or creaming. Nanoemulsions of the oil-in-water (O/W) type have been investigated and used in practical applications for a long time [1-5]. However, they have experienced growing interest and very active development in recent years, as reflected by publications [6-16] and patents [17-27] on this subject.
Pricing Multivariate Contingent Claims Using Estimated Risk-Neutral Density Functions (1997)

Many asset price series exhibit time-varying volatility, jumps, and other features inconsistent with assumptions about the underlying price process made by standard multivariate contingent claims (MVCC) pricing models. This paper develops an interpolative technique for pricing MVCCs ' flexible NLS pricing ' that involves the estimation of a flexible multivariate risk-neutral density function implied by existing asset prices. As an application, the flexible NLS pricing technique is used to value several bivariate contingent claims dependent on foreign exchange rates in 1993 and 1994. The bivariate flexible risk-neutral density function more accurately prices existing options than the bivariate lognormal density implied by a multivariate geometric brownian motion. In addition, the bivariate contingent claims analyzed have substantially different prices using the two density functions suggesting flexible NLS pricing may improve accuracy over standard methods.
Two essential FtsH proteases control the level of the Fur repressor during iron deficiency in the cyanobacterium Synechocystis sp. PCC 6803 (2014)

The cyanobacterium Synechocystis sp. PCC 6803 expresses four different FtsH protease subunits (FtsH1-4) that assemble into specific homo- and heterocomplexes. The FtsH2/FtsH3 complex is involved in photoprotection but the physiological roles of the other complexes, notably the essential FtsH1/FtsH3 complex, remain unclear. Here we show that the FtsH1 and FtsH3 proteases are involved in the acclimation of cells to iron deficiency. A mutant conditionally depleted in FtsH3 was unable to induce normal expression of the IsiA chlorophyll-protein and FutA1 iron transporter upon iron deficiency due to a block in transcription, which is regulated by the Fur transcriptional repressor. Levels of Fur declined in the WT and the FtsH2 null mutant upon iron depletion but not in the FtsH3 downregulated strain. A similar stabilizing effect on Fur was also observed in a mutant conditionally depleted in the FtsH1 subunit. Moreover, a mutant overexpressing FtsH1 showed reduced levels of Fur and enhanced accumulation of both IsiA and FutA1 even under iron sufficiency. Analysis of GFP-tagged derivatives and biochemical fractionation supported a common location for FtsH1 and FtsH3 in the cytoplasmic membrane. Overall we propose that degradation of the Fur repressor mediated by the FtsH1/FtsH3 heterocomplex is critical for acclimation to iron depletion.
Delivery of quantum dot bioconjugates to the cellular cytosol: release from the endolysosomal system (2010)

To realize their full potential as intracellular imaging and sensing reagents, robust and efficient methods for the targeted cellular delivery of luminescent semiconductor quantum dots (QDs) must be developed. We have previously shown that QDs decorated with histidine-terminated polyarginine cell-penetrating peptides (CPP) are rapidly and specifically internalized via endocytosis by several mammalian cell lines with no cytotoxicity. Here we demonstrate the long-term intracellular stability and fate of these QD-peptide conjugates. We found that the QD-peptide conjugates remain sequestered within endolysosomal vesicles for up to three days after delivery. However, the CPP appeared to remain stably associated with the QD within these acidic vesicles over this time period. Hence, we explored a number of techniques to either actively deliver QDs directly to the cytosol or to facilitate the endosomal release of endocytosed QDs to the cytosol. Active methods (e.g., electroporation) delivered only modest amounts of QDs to the cytosol that appeared to form aggregates. Delivery of QDs using polymer-based transfection reagents resulted primarily in the endosomal sequestration of the QDs, although one commercial polymer tested delivered QDs to the cytosol but only after several days in culture and with a considerable degree of polymer-induced toxicity. Finally, a modular, amphiphilic peptide containing functionalities designed for cell penetration and vesicular membrane interaction demonstrated the ability to deliver QDs in a well-dispersed manner to the cytosol. This peptide mediated rapid QD uptake followed by a slower efficient endosomal release of the QDs to the cytosol that peaked at 48 hours post-delivery. Importantly, this QD-peptide conjugate elicited minimal cytotoxicity in two cell lines tested. A more detailed understanding of the mechanism of the peptide's uptake and endosomal escape attributes will lead to the design of further QD conjugates for targeted imaging and sensing applications.
Ultrastructure of Mast Cells and Basophils (2005)

Basophils and mast cells are similar but unique secretory cells which play a central role in inflammatory and immediate allergic reactions. In this book, the author reviews the ultrastructural studies of basophils and mast cells performed since the publication of an earlier monograph in 1991. These studies include the use of ultrastructural rules t
ChemInform Abstract: HYDRIDE TRANSFER FROM TRANSITION METAL HYDRIDES TO DIHAPTO ACYL LIGANDS (1985)

Abstract Die Reaktionen des Dihaptoacylliganden in den Zr‐Komplexen (I) mit einer Reihe von Metallhydriden, wie z.B. (Il)‐(IV), werden hinsichtlich einer Wasserstoff‐ übertragung untersucht.
Figure S2 from Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes (2023)

&lt;p&gt;Protein expression levels of R loop regulators in U2AF1(WT)- or U2AF1(S34F)-expressing cells.&lt;/p&gt;
Mixture Properties of Recycled Central Plant Materials (1978)

The objectives of the research reported are to (a) define the material properties of central plant recycled mixes in Texas, (b) compare properties of these recycled mixes with conventional paving mixtures normally used in Texas, (c) evaluate the performance of the pavements containing central plant recycled mixes, and (d) compare performance of pavements constructed with recycled and conventional paving mixtures. Hveem, Marshall, resilient modulus, indirect tensile, direct tensile, and water sensitivity properties are reported for the recycled mixtures compacted both in the laboratory and under normal field procedures. Bituminous mixtures investigated include recycled asphalt concrete and recycled portland cement concrete. Performance is reported in terms of serviceability index as measured by a ride meter and by the use of a visual condition survey. The results of this study indicate that suitable bituminous mixtures can be produced by central plant recycling operations. Performance of pavements containing recycled mixtures appears to be suitable.
Ordering phenomena in thin polystyrene films (1981)

Abstract Ordering of polystyrene (PS) molecules in thin films collapsed from toluene solutions onto a glass substrate by dip coating is studied in relation to the polymer molecular weight and its distribution. The degree of ordering of chain elements is deduced from measurements of film birefringence, between the normal and parallel directions to the film surface, as a function of film thickness. A technique has been developed for measuring this birefringence by monitoring the intensity of laser light passing through the film, as a function of the angle of incidence. Films of monodisperse low‐molecular‐weight PS exhibit high ordering very close to the substrate, but this ordering decays within 1 μm from the glass surface. Films of monodisperse high‐molecular‐weight PS, on the other hand, exhibit a much smaller, but very long‐range degree of order. In a blend of PS of these two molecular weights, as well as in a polydisperse sample, these effects appear in tandem. The long‐range ordering effect, evident in the 100,000 molecular weight polystyrene films, is much smaller in magnitude in lower‐molecular‐weight films, reflecting probably the importance of chain entanglements.
Noisy data-rate limited estimation: renewal codes (2004)

We consider the problem of estimating the state of a system whose observations are transmitted from the sensor to the estimator over a binary symmetric channel (BSC). A coder at the sensor encodes its data into channel inputs. The estimator receives the channel output and estimates the state. There is a perfect 'reverse' channel from the estimator back to the coder, so the coder has full knowledge of the decoder. Such a system model is appropriate when the coder is power limited, but the decoder is not. The existence of a stable estimator (i.e. one with bounded estimation error) depends on two parameters: the degree of instability of the system, and the channel error probability. We present estimators for a subset of these parameters. It is difficult to design of a coder-decoder pair for a stable estimator. Classical codes for the BSC cannot be used, because they introduce large coding delays, hence large errors in the state estimate. We need codes that simultaneously impose very small delays and reduce decoding errors. These considerations point to a rich class of design problems that lie in the intersection of real-time control and communication. Previous work addressed this problem using a non-constructive random coding argument. The estimator presented here is constructive and has very low complexity. Surprisingly, too, our estimator works for parameter values not covered by the random coding argument.
SH2-Bα is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase (1998)

We identified SH2-Balpha as an insulin-receptor-binding protein based on interaction screening in yeast hybrid systems and co-precipitation in cells. SH2-Balpha contains pleckstrin-homology ('PH') and Src homology 2 (SH2) domains and is closely related to APS (adapter protein with a PH domain and an SH2 domain) and lnk, adapter proteins first identified in lymphocytes. SH2-Balpha is ubiquitously expressed and is present in rat epididymal adipose tissue, liver and skeletal muscle, physiological sites of insulin action. On SDS/PAGE, SH2-Balpha migrates at a molecular mass of 98 kDa, although the predicted size of SH2-Balpha is 79.6 kDa. Insulin causes an electrophoretic mobility shift. SH2-Balpha can be immunoprecipitated using anti-(insulin receptor) antibody from insulin-stimulated cells. Anti-phosphotyrosine antibody or the growth factor receptor-binding protein 2 (Grb2) SH2 domain precipitate SH2-Balpha after insulin stimulation, suggesting that SH2-Balpha is tyrosine-phosphorylated and may be a substrate for the insulin receptor. The SH2-Balpha SH2 domain did not interact with insulin-receptor substrate (IRS) proteins or epidermal-growth-factor receptor. Mutation of the juxtamembrane and C-terminus of the insulin receptor did not abolish the interaction with the SH2 domain. This was further confirmed using a panel of activation-loop single point mutants where mutation of Tyr1158, Tyr1162 and Tyr1163 abolished interaction. Thus SH2-Balpha is a likely component in the insulin-signalling pathway and may function as an alternative signalling protein by interacting with the activation loop of the insulin-receptor cytoplasmic domain.
Synthesis and properties of a redox-switchable calix[6]arene-based molecular lasso (2019)

A self-complexing lasso-like molecule has been synthesised as the first example of a calix[6]arene-based [1]pseudorotaxane. This artificial molecular lasso can be switched between self-threaded and dethreaded structures by redox stimulation.
Concurrent execution semantics and sequential simulation algorithms for the metropolis meta-model (2002)

This paper presents the simulation techniques that are available in Metropolis, an inter-disciplinary research project that develops a design methodology, supported by a comprehensive design environment and tool set, for embedded systems. System behavior is non-deterministic in general, especially in the beginning of the design process, when several key decision, such as the mapping on an implementation platform, have not yet been made, and thus the traces obtainable by simulation are not unique even under the same input sequence. One may want to visit as many traces as possible for regression tests at the final stage of designs, or may just need one valid trace for a quick validation of the design at an early stage. Our techniques can adapt to these different objectives easily. They are also platform-independent in that simulation using different languages, such as SystemC 2.0, Java, and C++ with a thread library, are possible. This feature is important for co-simulation between designs captured in Metropolis and those that have been already designed in other languages.
Suggestion to Complete the Canonical Genetic Code: The Proteomic Code and Nucleic Acid Assisted Protein Folding (2016)

Background: This research was carried out to provide a summary of a series of bioinformatical observations between 2002 and 2012 concerning the structure of nucleic acids and codons, the interaction between codons and nucleic acids and the general concept of translation. Methods: Public databases and resources, together with assays to determine the free folding energies in various codon residues, were utilized during this study. Results: This study demonstrates that widely-held paradigms within the field of molecular biology should be modified. In particular, it suggests that codons developed in association with the encoded amino acids, and that wobble bases are not randomly chosen in synonymous codons, since these have well-defined roles in determining the structure of nucleic acids and their folding energies. Furthermore, the proteomic code determines that co-locating amino acids are preferentially encoded by complementary codons (at least at the 1st and 3rd codon positions), and structural information transfer between nucleic acids and proteins during translation requires direct contact between “dedicated” amino acids and their codons. In addition, this study highlights the fact that there is a tRNA cycle that allows the possibility of direct codon amino acid contact. Conclusions: These observations provide a more complete understanding of the redundant Genetic Code and the mechanism of protein folding. Furthermore, the proteomic code provides the first real possibility for scientists to design interacting peptides that have high affinity and specificity for target peptides, with the potential to accelerate the growth of affinity assays and the integration of large numbers of affinity tests into chips.
Cutting Edge: Parathyroid Hormone Facilitates Macrophage Efferocytosis in Bone Marrow via Proresolving Mediators Resolvin D1 and Resolvin D2 (2014)

Bone marrow macrophages stimulate skeletal wound repair and osteoblastic bone formation by poorly defined mechanisms. Specialized proresolving mediators of inflammation drive macrophage efferocytosis (phagocytosis of apoptotic cells) and resolution, but little is known regarding this process in the bone marrow. In this study, metabololipidomic profiling via liquid chromatography mass spectrometry revealed higher levels of specialized proresolving mediators in the bone marrow relative to the spleen. The endocrine and bone anabolic agent parathyroid hormone increased specialized proresolving mediator levels, including resolvins (Rvs), in bone marrow. Human and murine primary macrophages efferocytosed apoptotic osteoblasts in vitro, and RvD1 and RvD2 (10 pM-10 nM) enhanced this process. These findings support a unique profile of specialized lipid mediators in bone marrow that contribute to a feedback system for resolution of inflammation and maintenance of skeletal homeostasis.