gebhart/patrepeval huggingface dataset:
Moment method analysis and genetic algorithm design of shaped beam pillbox antennas (2004)

This paper describes a design methodology for designing shaped beam pillbox antennas using a spectrum of two-dimensional solutions (S2DS) and genetic algorithms. The pillbox antenna is a type of parallel plate waveguide antenna that can be thought of as a cylindrical reflector and feed system confined between two parallel plates. The pillbox antenna can in many respects be analyzed as a two-dimensional structure, or be divided in two two-dimensional problems, as we outline here: one for the parallel plate reflector system and one for the outer two-dimensional horn. The full three-dimensional pattern is obtained by pattern multiplication with a very high degree of accuracy in the region of interest. Likewise, the total gain is efficiently calculated as the product of the elevation gain and the azimuth gain.
Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase. (1986)

The amino acid sequence of the heat-stable inhibitor of the cAMP-dependent protein kinase (PKI) was determined recently [Scott, J. D., Fischer, E. H., Takio, K., Demaille, J. G. & Krebs, E. G. (1985) Proc. Natl. Acad. Sci. USA 82, 5732-5736]. An earlier report [Scott, J. D., Fischer, E.H., Demaille, J. G. & Krebs, E. G. (1985) Proc. Natl. Acad. Sci. USA 82, 4379-4383] showed that at least part of the inhibitory domain of PKI is located in a 20-residue segment extending from residue 11 to residue 30: Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-Ile-Leu-Val-Ser- Ser-Ala . In the present study, we further mapped the inhibitory region of PKI by addition or deletion of residues at both ends of this peptide and by substitutions for specific amino acids. The results show that (i) deletion of residues 25-30 did not change inhibitory activity but addition of residues toward the amino terminus increased the inhibitory potency up to 150-fold (Ki 4.8 nM), to a level approaching that of PKI; (ii) replacement of alanine-21 by serine converted the inhibitor into a substrate having a relatively low affinity (Km 280 microM) for the enzyme; (iii) replacement of alanine-21 by phosphoserine or alpha-aminobutyric acid decreased inhibitory activity by a factor of 120 and 20, respectively; (iv) replacement of serine-13 had essentially no effect, whereas substitution of threonine-16 decreased inhibitory activity. The greatest decreases of inhibitory potency occurred with replacements of the arginines in positions 18 and 19.
Logical Necessity (1948)

It may sometimes be useful in philosophy to state a method of argument in very simple and even over-simplified terms; it may at a certain stage be useful to ignore for the moment the details and difficulties of particular philosophical arguments, and to try to state simply what is commonly assumed in a variety of different and even opposing arguments.
Channel estimation using feedback (2008)

It is well known from the information theory literature that in the presence of a memoryless channel, as well as some channels with memory, the existence of feedback does not improve channel capacity, but can contribute dramatically to the simplification of the encoder and the decoder. In this paper, we focus on estimating the parameters of an unknown channel when a feedback link from the decoder to the encoder is given. We examine different types of channels and study the conditions under which feedback improves the estimation in the sense of the Cramer-Rao bound (CRB). We additionally find what is the best strategy for designing channel input signals and the channel parameter estimator of the receiver. By assuming a certain class of parametric models for the channel, we show that feedback is essential when some nuisance parameters of the model are unknown, but it is superfluous when there are no unknown nuisance parameters.
Dupilumab: human monoclonal antibody against IL-4Ralpha formoderate to severe atopic dermatitis (2017)

Atopic dermatitis (AD) is one of the most common skin disorders with a prevalence of about 20% in children and affecting adults in significant numbers. Moderate to severe AD significantly impairs a patient's quality of life with severe pruritus as a major issue that impairs sleep and contributes to major psychological disturbances. Detailed studies of its pathogenesis have revealed that immune mechanisms are involved including activation of T helper type 2 cells (Th2). Dupilumab is a fully human Ig4 monoclonal antibody directed against the interleukin-4 receptor subunit α (IL-4Rα) of IL-4 and IL-13 receptors. In clinical studies it has been demonstrated to significantly reduce the molecular signature in the skin of patients with AD and to significantly reduce the clinical manifestations of moderate to severe AD. It also very importantly significantly reduces the pruritus of moderate to severe AD thus improving the patients' quality of life. Dupilumab is administered by subcutaneous injection every other week. It was approved by the FDA in March 2017 for the treatment of moderate to severe AD.
Greffes cérébrales: aspects éthiques et scientifiques. (1991)

SCOPUS: re.j
The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11 (1997)

A new common region of virus integration, Evi11, has been identified in two retrovirally induced murine myeloid leukemia cell lines, NFS107 and NFS78. By interspecific backcross analysis, it was shown that Evi11 is located at the distal end of mouse chromosome 4, in a region that shows homology with human 1p36. The genes encoding the peripheral cannabinoid receptor (Cnr2) and alpha-L-fucosidase (Fuca1) were identified near the integration site by using a novel exon trapping system. Cnr2 is suggested to be the target gene for viral interference in Evi11, since proviruses are integrated in the first intron of Cnr2 and retroviral integrations alter mRNA expression of Cnr2 in NFS107 and NFS78. In addition, proviral integrations were demonstrated within the 3' untranslated region of Cnr2 in five independent newly derived CasBrM-MuLV (mouse murine leukemia virus) tumors, CSL13, CSL14, CSL16, CSL27, and CSL97. The Cnr2 gene encodes a seven-transmembrane G-protein-coupled receptor which is normally expressed in hematopoietic tissues. Our data suggest that the peripheral cannabinoid receptor gene might be involved in leukemogenesis as a result of aberrant expression of Cnr2 due to retroviral integration in Evi11.
Low-Insertion-Loss and Power-Efficient 32 × 32 Silicon Photonics Switch With Extremely High-Δ Silica PLC Connector (2018)

We fabricate a 32 × 32 silicon photonics switch on a 300-mm silicon-on-insulator wafer by using our complementary metal-oxide-semiconductor pilot line equipped with an immersion ArF scanner and demonstrate an average fiber-to-fiber insertion loss of 10.8 dB with a standard deviation of 0.54 dB, and on-chip electric power consumption of 1.9 W. The insertion loss and the power consumption are approximately 1/60, and less than 1/4 of our previous results, respectively. These significant improvements are achieved by design and fabrication optimization of waveguides and intersections on the chip, and by employing a novel optical fiber connector based on extremely-high-Δ silica planar-lightwave-circuit (PLC) technology. The minimum crosstalk was -26.6 dB at a wavelength of 1547 nm, and -20-dB crosstalk bandwidth was 3.5 nm. Furthermore, we demonstrate low-crosstalk bandwidth expansion by using output port exchanged element switches. We achieve a -20 dB crosstalk bandwidth of 14.2 nm, which is four-times wider than that of the conventional element switch based 32 × 32 switch.
Adaptation in Delivering Integrated Care: The Tension Between Care and Evidence-Based Practice (2018)

Clinical practice is assumed to be informed and supported by evidence-based clinical research. Nonetheless, clinical practice often deviates from the research evidence base, sometimes leading and sometimes lagging. Two examples from integrated care in mental health care (care for serious mental illness and collaborative mental health care in primary care settings) illustrate the natural space and therefore tension between evidence and implementation that needs to be better understood. Using the tools and perspectives of both examples, the authors present a framework for the connected relationship between practice and research that is founded on measurement and uses iterative adaptation guided by oversight of and feedback from the stakeholders in this process.
Securing network location awareness with authenticated DHCP (2007)

Network location awareness (NLA) enables mobile computers to recognize home, work and public networks and wireless hotspots and to behave differently at different locations. The location information is used to change security settings such as firewall rules. Current NLA mechanisms, however, do not provide authenticated location information on all networks. This paper describes a novel mechanism, based on public-key authentication of DHCP servers, for securing NLA at home networks and wireless hotspots. The main contributions of the paper are the requirements analysis, a naming and authorization scheme for network locations, and the extremely simple protocol design. The mobile computer can remember and recognize previously visited networks securely even when there is no PKI available. This is critical because we do not expect the majority of small networks to obtain public-key certificates. The protocol also allows a network administrator to pool multiple, heterogeneous access links, such as a campus network, to one logical network identity. Another major requirement for the protocol was that it must not leak information about the mobile host’s identity or affiliation. The authenticated location information can be used to minimize attack surface on the mobile host by making security-policy exceptions specific to a network location.
Design-Considerations regarding Silicon/Graphite and Tin/Graphite Composite Electrodes for Lithium-Ion Batteries (2018)

An analytical model is proposed to investigate properties of composite electrodes that utilize more than one active material. We demonstrate how the equations can be applied to aid in the design of electrodes by comparing silicon-graphite and tin-graphite composite negative electrodes as examples with practical relevance. Based on simple assumptions, the results show how volume expansion tolerance and initial porosity are important factors for the achievable gravimetric and volumetric capacities as well as volumetric energy density. A Si-alloy/graphite composite electrode is used as an experimental system to corroborate the formulated analysis. Kinetic limitations are also addressed based on a novel heuristic approach.
1046. Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) Administered as a Booster to Adults ≥ 59 Years of Age (2021)

Abstract Background MenACYW-TT (MenQuadfi®, Sanofi) is a quadrivalent (serogroups A, C, W, and Y) meningococcal tetanus toxoid conjugate vaccine. It was recently approved for use in persons aged ≥ 2 years in the US and persons aged ≥ 1 year in Europe and certain other countries; trials in infants as young as 6 weeks are ongoing. This study evaluated seroresponse after a MenACYW-TT booster given to adults who received either quadrivalent meningococcal polysaccharide vaccine (MSPV4) or MenACYW-TT three years earlier at age ≥ 56 years. Immune persistence up to 7 years after primary vaccination was also evaluated. Methods This was a Phase 3 randomized, open-label study (NCT04142242) of adults aged ≥ 59 years who participated in previous studies of MenACYW-TT vs MPSV4 (NCT01732627 and NCT02842866). The study was conducted in the US and Puerto Rico. Immune response and persistence were assessed with a serum bactericidal assay using human complement (hSBA). Sufficiency of the vaccine seroresponse was considered demonstrated if the lower limit of the 1-sided 97.5% CI for the percentage of subjects with an hSBA vaccine seroresponse against serogroups A, C, W and Y was &amp;gt; 40%. Safety data were collected up to 30 days after booster vaccination. Results A total of 471 persons were enrolled. Sufficiency of a MenACYW-TT booster was demonstrated for MPSV4- and for MenACYW-TT-primed subjects. hSBA seroresponse rates were higher among MenACYW-TT- vs MPSV4-primed subjects (79.3%–93.1% vs 49.2%–60.8%, respectively). Three to 7 years after primary vaccination, hSBA geometric mean titers (GMTs) and seroprotection rates (SPRs) declined in both MenACYW-TT- and MPSV4-primed subjects, with hSBA GMTs and SPRs for serogroups C, W, and Y generally remaining higher for MenACYW-TT- vs MPSV4-primed subjects; those for serogroup A were similar regardless of priming vaccine. Rates of adverse events following a MenACYW-TT booster were similar between MenACYW-TT- and MPSV4-primed subjects. No safety concerns were identified. Conclusion A MenACYW-TT booster was well tolerated and immunogenic when administered to either MPSV4- or MenACYW-primed adults aged ≥ 59 years. Up to 7 years after primary vaccination, immune persistence for serogroups C, W, and Y tended to be greater for MenACYW-TT vs MPSV4. Disclosures Corwin A. Robertson, MD, MPH, FACP, Sanofi Pasteur (Employee, Other Financial or Material Support, Stockholder) Alexandre Selmani, PhD, Sanofi Pasteur (Employee) Katherine Galarza, MD, Sanofi Pasteur (Employee) Philipp Oster, MD, Sanofi Pasteur (Employee, Stockholder)
Cellular Functionality on Nanotubes of Ti-30Ta Alloy (2014)

Recent studies have identified strong correlations between anodized metals and the production of highly biomimetic nanoscale topographies. These surfaces provide an interface of enhanced biocompatibility that exhibits a high degree of oxidation and surface energy. In this study, Human dermal fibroblasts (HDF, neonatal) were utilized to evaluate the biocompatibility of Ti-30Ta nanotubes after 1 day of culture. The anodization process was performed in an electrolyte solution containing HF (48%) and H 2 SO 4 (98%) in the volumetric ratios 1:9 with the addition of 5% dimethyl sulfoxide (DMSO) at 35V for 40 min. Cellular analysis identified improved fibroblast functionality on the nanotube surface, showing increased elongation, and extracellular matrix production on the Ti-30Ta nanotubes. The results presented identify improved cellular interaction on Ti-30Ta nanotubes as compared to the control substrates. Thus, the formation of the nanotube on Ti30Ta alloy may have potential application as interface for implantable devices.
Antiretroviral activity of two polyisoprenylated acylphloroglucinols, 7-epi-nemorosone and plukenetione A, isolated from Caribbean propolis (2010)

Despite 7-epi-nemorosone and plukenetione A sharing some structural core elements, the mechanism of action involved in their antiretroviral activity seems to be different. We propose that 7-epi-nemorosone inhibits the viral replication by interrupting the Akt/PKB signaling cascade, as was demonstrated previously in various cell lines. Since plukenetione A effectively inhibits the enzymatic activity of MMLV reverse transcriptase at concentrations that show antilentiviral activity, we suggest that this small molecule acts by interfering with the enzyme's catalytic site.
Review: Role of the augmentation index in hypertension (2008)

Recent studies have revealed the clinical usefulness of central blood pressure (BP) as an index of risk for cardiovascular disease. The arterial pulse waveform is the sum of the forward pressure wave generated by left ventricular ejection and a backward propagating wave that is subsequently reflected from the peripheral site, and the time point at which these forward and backward propagating waves merge and the amplitude of the reflected (backward) wave affect the level of central BP. The augmentation index (AIx) has been proposed as a measure of the wave reflection, and its clinical usefulness has also been evaluated. In the process, the non-linear relationship between age and AIx, the prognostic value of AIx, and the various effects of antihypertensive drugs on AIx have been shown. However, the clinical usefulness of AIx has not been established, and several questions about its use remain. Future studies will be needed to address these questions, and may contribute to important changes in the management of cardiovascular disease. In this review, we present recent findings on the AIx and discuss the role of this parameter in clinical practice.
VEGFR-2 conformational switch in response to ligand binding (2016)

VEGFR-2 is the primary regulator of angiogenesis, the development of new blood vessels from pre-existing ones. VEGFR-2 has been hypothesized to be monomeric in the absence of bound ligand, and to undergo dimerization and activation only upon ligand binding. Using quantitative FRET and biochemical analysis, we show that VEGFR-2 forms dimers also in the absence of ligand when expressed at physiological levels, and that these dimers are phosphorylated. Ligand binding leads to a change in the TM domain conformation, resulting in increased kinase domain phosphorylation. Inter-receptor contacts within the extracellular and TM domains are critical for the establishment of the unliganded dimer structure, and for the transition to the ligand-bound active conformation. We further show that the pathogenic C482R VEGFR-2 mutant, linked to infantile hemangioma, promotes ligand-independent signaling by mimicking the structure of the ligand-bound wild-type VEGFR-2 dimer.
Die Beteiligung junger Werktätiger an der Durchsetzung des wissenschaftlich-technischen Fortschritts in der Industrie : Bericht 'Schöpfertum' zur Komplexstudie 1984 (1985)

Als Bestandteil der "Komplexstudie '84" wurde diese Studie unter Kombinaten und Kombinatsbetrieben durchgeführt, die besondere Erfolge bei der Meisterung des wissenschaftlich-technischen Fortschritts haben. Im Hinblick auf ihre Stellung zur Durchsetzung des wissenschaftlich-technischen Fortschritts werden drei Gruppen miteinander verglichen: (1) Arbeiter, (2) Angestellte ohne und (3) mit Hochschulabschluß bzw. Fachhochschulabschluß. Die Einstellung der jungen Werktätigen zur Meisterung des wissenschaftlich-technischen Fortschritts wird u.a. anhand der zentralen Lebensorientierung und der Beteiligung an wichtigen politisch-ökonomischen Aktivitäten herausgearbeitet. In einem zweiten Schritt der Auswertung der Daten werden ausgewählte Bedingungen für die Beteiligung an der MMM (Messe der Meister von Morgen)-Bewegung und Neuerertätigkeit erfaßt. Dazu gehören die Einschätzung der eigenen Kenntnisse und Fähigkeiten zur Beteiligung daran, das Interesse an Fragen des wissenschaftlich-technischen Fortschritts, Probleme des kollektiven Klimas und des eigenen aktiven generellen und exponatsspezifischen Informationsverhaltens. (ICA)
Cowden's disease: a further indication for prophylactic mastectomy. (1986)

Cowden's disease (multiple hamartoma syndrome) is a syndrome involving abnormalities of multiple organ systems. Transmitted in an autosomal dominant pattern, it carries a high frequency of mammary carcinoma in early middle age in affected women. The hyperkeratotic cutaneous and gingival markers of the disease are its principal overt manifestations. Prophylactic bilateral total mastectomy with optional immediate reconstruction is recommended for women Cowden's disease. An illustrative family with the disease is presented in which one affected young woman was found to have invasive mammary carcinoma with regional metastasis at the time of prophylactic mastectomy.
Charge transfer process for carbon-related center in semi-insulating carbon-doped GaN (2018)

Electron paramagnetic resonance (EPR) spectroscopy was used to study the point defects in 2 × 1017–1019 cm−3 C-doped GaN substrates grown by hydride vapor phase epitaxy. The intensity of an isotropic signal with g = 1.987 ± 0.001 increased monotonically with the carbon concentration, indicating that the EPR signal represents a carbon-related defect. In each sample, the signal intensity increased under illumination with photon energy greater than 2.75 eV, and the photo-induced signal decreased with subsequent illumination at 0.95 eV. A second signal, well-documented to be a shallow donor, appeared along with the g = 1.987 signal in the most lightly doped samples. The appearance of the donor confirms that the photo-induced increase is caused by excitation of an electron to the conduction band and implies that a defect level for the carbon-related center is about 1 eV above the valence band edge, consistent with temperature-dependent Hall measurements.
Low angular-dispersion microwave absorption of a metal dual-period nondiffracting hexagonal grating (2005)

The microwave (11.3&amp;lt;λ0&amp;lt;16.7mm) reflectivity response of a nondiffracting dual-period hexagonal grating is explored. In three directions at 60° to each other, the aluminum grating has a repeat period of 7.2mm in which are three equally spaced grooves, one being slightly shallower than the other two. This dual-period (λg and λg∕3) structure exhibits strong microwave absorption at several different frequencies. In addition, some of the absorptions are almost completely independent of the angle of incidence and polarization of the microwave radiation.
Mutagenesis of codon 248 of the human p53 tumor suppressor gene by N-ethyl-N-nitrosourea. (1994)

Base pair mutations in the p53 tumor suppressor gene are among the most frequently observed genetic changes in human malignancies. Several mutational hotspots have been identified and tumor- and tissue-specific differences have been observed. We studied the mutability of hotspot codon 248, CGG, in human fibroblasts in response to the alkylating agent N-ethyl-N-nitrosourea (ENU) by MspI RFLP/PCR analysis. Alkylating agents are implicated as etiological agents in carcinogenesis in the gut and other tissues in the human. ENU induced preferentially G to A transitions in the non-transcribed strand. The predominant mutation involving the G-residue of the CpG dinucleotide was observed with an absolute frequency of 4 x 10(-7). The corresponding C to T transition in the first position of codon 248 was observed at several fold lower frequency suggesting more efficient excision repair of the transcribed strand. The G to A transition in the third position of codon 248 occurred at low frequency. Our results are compatible with a role for aliphatic alkylating agents in human tumors with codon 248 mutations since almost all mutations reported in this codon are transitions in the CpG-dinucleotide.
P1.13 - Application of a Touch-Probe Array for the Parallel Measurement of Microstructures (2009)

This paper deals with the development of a coordinate measuring machine for parallel tactile probing of microstructures. The particular challenges due to the parallel probing will be discussed and the concluding results regarding the construction, the control and the calibration will be outlined.
Efficient algorithms for lateral gene transfer problems (2001)

This paper develops a model for lateral gene transfer events (a.k.a. horizontal gene transfer events) between a set of gene trees T1, T2, …, Tk and a species tree S. To the best of our knowledge, this model possesses a higher degree of biological and mathematical soundness than any other model proposed in the literature. Among other biological considerations, the model respects the partial order of evolution implied by S. Within our model, we identify an activity parameter that measures the number of genes that are allowed to be simultaneously active in the genome of a taxa and show that finding the most parsimonious scenario that reconciles the disagreeing gene trees with the species tree is doable in polynomial time when the activity level and number of transfers are small, but intractable in general. To the best of our knowledge, all other models proposed in the literature assume implicitly that the activity is one. Finally, using a dataset of bacterial gene sequences from [4], our implementations found 5 optimal scenarios; one of which is the scenario proposed by the authors in [4].