gebhart/patrepeval huggingface dataset:
RAID-x: a new distributed disk array for I/O-centric cluster computing (2000)

A new RAID-x (redundant array of inexpensive disks at level x) architecture is presented for distributed I/O processing on a serverless cluster of computers. The RAID-x architecture is based on a new concept of orthogonal striping and mirroring (OSM) across all distributed disks in the cluster. The primary advantages of this OSM approach lie in: (1) a significant improvement in parallel I/O bandwidth; (2) hiding disk mirroring overhead in the background; and (3) greatly enhanced scalability and reliability in cluster computing applications. All claimed advantages are substantiated with benchmark performance results on the Trojans cluster built at USC in 1999. The authors discuss the issues of scalable I/O performance, enhanced system reliability, and striped checkpointing on distributed RAID-x in a serverless cluster environment.
Long-distance fiber-optical transfer of a radio-frequency control signal for radio-astronomy and sensing applications (2016)

Passive phase-conjugation enables precise fiber-optical transfer of radio-frequency reference signals over long distances, yielding high long-term stability for radio-astronomy and remote-sensing applications without active path-length stabilization
188 INTRAPULMONARY ADMINISTRATION OF MESENCHYMAL STEM CELLS REDUCES ENDOTOXIN-INDUCED ACUTE LUNG INJURY AND MORTALITY IN A MOUSE MODEL. (2006)

<h3>Purpose</h3> Mesenchymal stem cells are bone marrow-derived cells that have the ability to differentiate into cells of different lineages including pulmonary epithelium. Prior studies in lung injury models have focused on administration of stem cells by the intravenous route. Our objective was to test the potential benefit from intrapulmonary administration of mesenchymal stem cells in a mouse model of endotoxin-induced acute lung injury by measuring extravascular lung water and survival. <h3>Methods</h3> The mesenchymal stem cells were obtained from GFP-C57BL/6 mice and were propagated in culture. C57BL/6 mice were used for all experiments, and acute lung injury was established by intratracheal (it) instillation of LPS from <i>E. coli</i> 055:B5 (5 mg/kg). Four hours after LPS instillation, mice received by its instillation either mesenchymal stem cells (750,000 cells in 30 μL) or PBS (30 μL). Mice were followed for 48 hours. The lungs were harvested and blood samples collected at 48 hours or earlier if the mice died. Further experiments using the same protocol were done with bronchoalveolar lavage (BAL) and plasma samples for the measurement of TNF-α and MIP-2 by R&amp;D ELISA kits. <h3>Results</h3> Intrapulmonary mesenchymal stem cells reduced pulmonary edema compared to controls treated with PBS (wet-to-dry lung water 5.4 ± 1.3 vs 6.9 ± 1.2 g water/g dry lung, data as mean ± SD, <i>p</i> &lt; .01, n = 12 for both groups). In addition, the stem cells improved survival over the 48-hour time period (100% in the stem cell group vs 31% in the control group, p &lt; .01, n = 13 for both groups). Furthermore, mesenchymal stem cells decreased both the BAL levels of TNF-α and MIP-2 compared to control mice (BAL TNF-α: 174 ± 92 vs 798 ± 531 pg/mL, p = .02; BAL MIP-2: 207 ± 67 vs 717 ± 567 pg/mL, p = .05; all comparisons are stem cell treated vs control group, n = 6 for both groups). Significant reductions were also found in the plasma levels of TNF-α and MIP-2 in the stem cell versus PBS control mice. <h3>Conclusions</h3> In LPS-induced acute lung injury in mice, the intrapulmonary administration of mesenchymal stem cells reduces the severity of lung injury and improves survival when given 4 hours after LPS instillation into the lung. This benefit appears to be mediated in part through a down-regulation of the acute inflammatory responses to endotoxin.
Cleavage of PITSLRE Kinases by ICE/CASP-1 and CPP32/CASP-3 during Apoptosis Induced by Tumor Necrosis Factor (1997)

Emerging evidence suggests that multiple aspartate-specific cysteine proteases (caspases (CASPs)) play a crucial role in programmed cell death. Many cellular proteins have been identified as their substrates and serve as markers to assay the activation of CASPs during the death process. However, no substrate has yet been unambiguously identified as an effector molecule in apoptosis. PITSLRE kinases are a superfamily of Cdc2-like kinases that have been implicated in apoptotic signaling and tumorigenesis. In this paper we report that tumor necrosis factor (TNF)-mediated apoptosis is associated with a CrmA- and Bcl-2-inhibitable cleavage of PITSLRE kinases, indicating a role for CASPs. Testing of seven murine CASPs for their ability to cleave p110 PITSLRE kinase alpha2-1 in vitro revealed that only CASP-1 (ICE (interleukin-1beta-converting enzyme)) and CASP-3 (CPP32) were able to produce the same 43-kDa cleavage product as observed in cells undergoing TNF-induced apoptosis. Mutational analysis revealed that cleavage of p110 PITSLRE kinase alpha2-1 occurred at Asp393 within the sequence YVPDS, which is similar to that involved in the CASP-1-mediated cleavage of prointerleukin-1beta. TNF-induced proteolysis of PITSLRE kinases was still observed in fibroblasts from CASP-1(0/0) mice. These data implicate CASP-3 as a potentially important CASP family protease responsible for the cleavage of PITSLRE kinases during TNF-induced apoptosis.
Tight Approximation Bounds for the Seminar Assignment Problem (2016)

The seminar assignment problem is a variant of the generalized assignment problem in which items have unit size and the amount of space allowed in each bin is restricted to an arbitrary set of values. The problem has been shown to be NP-complete and to not admit a PTAS. However, the only constant factor approximation algorithm known to date is randomized and it is not guaranteed to always produce a feasible solution. In this paper we show that a natural greedy algorithm outputs a solution with value within a factor of $(1 - e^{-1})$ of the optimal, and that unless $NP\subseteq DTIME(n^{\log\log n})$, this is the best approximation guarantee achievable by any polynomial time algorithm.
Effect of Pregnancy, Postnatal Growth, and Gender on Renal Sulfate Transport (1999)

Serum sulfate concentrations are increased in infants, young children, and pregnant women, compared with adult values. The objective of this investigation was to examine the influences of age, gender, and pregnancy on renal sulfate transport using guinea pigs as an animal model. Membrane vesicles were isolated from the kidney cortex of male animals at four different ages, from male and female adult animals, and from pregnant and nonpregnant female animals. There were no significant differences in marker enzymes for the brush-border membrane (BBM) or basolateral membrane (BLM) among all groups examined. Uptake was determined by a rapid filtration method and membrane fluidity by measuring the steady-state fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene. The Vmax values for Na+ /sulfate co-transport in BBM were significantly increased with decreasing age, whereas the Km for this process was unchanged. The Vmax and Km for Na + /sulfate co-transport in BBM of pregnant animals were significantly higher than the values in the nonpregnant group. Bicarbonate-driven anion exchange of sulfate in BLM was not different among the different age groups. The Vmax for the bicarbonate/sulfate exchange process in BLM was not different between pregnant and nonpregnant groups; however, the Km for this process in BLM of pregnant animals was significantly greater than the value in nonpregnant animals. There were no gender-related differences in sulfate transport in BBM or BLM isolated from adult male and female animals. Renal BBM fluidity was increased with decreasing age and in pregnant animals, suggesting that altered membrane fluidity may represent one possible mechanism to explain the increased sodium/sulfate uptake in young and pregnant animals. The higher Vmax for Na+/sulfate co-transport in young and pregnant animals suggests that there is an increased density of co-transporter protein or an increase in the rate of movement of the carrier protein (i.e., turnover) once loaded with sodium and sulfate. This increased conservation of inorganic sulfate in young and pregnant guinea pigs may be related to the increased demand for sulfated substrates, such as sulfated glycosaminoglycans, during growth and development.
A global comparison of the cost of patented cancer drugs in relation to global differences in wealth (2017)

Cancer drugs are less affordable in middle-income countries than in high-income countries. Differential pricing may be an acceptable policy to ensure global affordability and access to highly active anti-cancer therapies.
2.09-µm degenerate femtosecond OPO with over 60% conversion efficiency and 0.6-W output (2014)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text K. A. Ingold, A. Marandi, C. W. Rudy, and R. L. Byer, "2.09-µm degenerate femtosecond OPO with over 60% conversion efficiency and 0.6-W output," in CLEO: 2014, OSA Technical Digest (online) (Optica Publishing Group, 2014), paper SM2I.4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Detection of moving obstacles for mobile robot using laser sensor (2011)

Detection of moving obstacles is a difficult problem of mobile robot navigation. Considering the dynamic unknown environments as research background, an autonomous detection method of moving obstacles based on laser sensor is presented. The polar-coordinates-based nearest neighbor approach is adopted to realize the spatial clustering of obstacles according to the ranging data of laser sensor. The characteristic parameters of clustering obstacles are analyzed. With the analysis of time association, the matching and classification algorithms of obstacles are designed. Finally, using a circular “puffing” method to update the parameters of moving obstacles. Simulation results show the effectiveness of the method.
Introduction to the special issue on human-computer interaction and collaborative virtual environments (2000)

Recent advances in both communication systems and collaboration technologies have resulted in a convergence of communication and interactive systems supporting different forms of collaboration across a community of users. Work on technology-mediated collaboration has traditionally taken one of two broad approaches. The first is to focus on the work activity itself, and to find ways to distribute and coordinate that activity across different individuals, perhaps working at different times and in different locations. This approach is embodied in many of the groupware products currently emerging in the marketplace. The second is to focus on the environment within which work takes place, whether that environment is the physical setting or the computational workspace, and find ways to allow people to come together in that environment to achieve collaborative work. This approach has tended to exploit the nature and organization of space as a means of managing work. The application of spatial concepts has considered both augmenting existing physical spaces with electronically sensitive physical artefacts, and virtual spaces into which users project their presence.
Improving atlantis TTI model building: OBN+NATS, prism waves & 3D RTM angle gathers (2011)

Ocean Bottom Node (OBN) acquisition has provided many advantages for building a more accurate salt geometry and subsalt velocity at Atlantis. Around the end of 2009, BP started to reprocess the data and rebuild the salt model using a Tilted Transverse Isotropy Reverse Time Migration (TTI RTM) workflow. TTI RTM 3D Angle Gather technology, developed in early 2010, was used in both supra‐salt and subsalt velocity tomography updates, taking advantage of the full azimuthal coverage of the OBN acquisition. RTM's capacity to image prism waves also contributed to the imaging and interpretation of complex salt fingers in the survey. Furthermore, migrating OBN common receiver gathers was more efficient than migrating towed‐streamer common shot gathers and allowed us to test over one hundred different salt scenarios. The TTI model building was a success and the subsalt image at Atlantis was substantially improved.
Enhancement of ZigBee and Wi-Fi security by a robust and fast chaotic algorithm (2011)

The security protocols used in ZigBee and Wi-Fi networks rely on stream cipher algorithms, like RC4 (Used in WEP and WPA) or AES-CTR (in WPA2), to encrypt data before transmission. RC4 is a fast algorithm, but represents some major flaws. AES is a very robust algorithm, but it is time consuming. For some industrial and medical applications, these algorithms don't respect the real-time and robustness requirements at the same time. Therefore, new fast stream ciphers where proposed in the eStream project, but also these ciphers has shown some weaknesses. On the other hand, chaotic functions properties have encouraged their use in crypto-systems for data security. In this paper, a new chaotic encryption algorithm is presented, to be used for data encryption in some industrial and medical applications where robustness and real time are both essential. It is composed from two perturbed PWLCM chaotic maps. Then, to quantify the security level and rapidity of our proposed algorithm, we compare it to the eStream finalist candidates and to the AES-CTR algorithm.
Preliminary Evaluation of Bt-Paba/Pas Test in Tropical Diabetes (1990)

Conference Abstract| January 01 1990 Preliminary Evaluation of Bt-Paba/Pas Test in Tropical Diabetes P Gagjee; P Gagjee 1Department of Gastroenterology, Royal Infirmary, Manchester M13 9WL, England and the Diabetes Research Centre, Madras 600013, India Search for other works by this author on: This Site PubMed Google Scholar P Pemberton; P Pemberton 1Department of Gastroenterology, Royal Infirmary, Manchester M13 9WL, England and the Diabetes Research Centre, Madras 600013, India Search for other works by this author on: This Site PubMed Google Scholar R Lobley; R Lobley 1Department of Gastroenterology, Royal Infirmary, Manchester M13 9WL, England and the Diabetes Research Centre, Madras 600013, India Search for other works by this author on: This Site PubMed Google Scholar C Chaloner; C Chaloner 1Department of Gastroenterology, Royal Infirmary, Manchester M13 9WL, England and the Diabetes Research Centre, Madras 600013, India Search for other works by this author on: This Site PubMed Google Scholar C Snehalatha; C Snehalatha 1Department of Gastroenterology, Royal Infirmary, Manchester M13 9WL, England and the Diabetes Research Centre, Madras 600013, India Search for other works by this author on: This Site PubMed Google Scholar V Mohan; V Mohan 1Department of Gastroenterology, Royal Infirmary, Manchester M13 9WL, England and the Diabetes Research Centre, Madras 600013, India Search for other works by this author on: This Site PubMed Google Scholar J Braganza J Braganza 1Department of Gastroenterology, Royal Infirmary, Manchester M13 9WL, England and the Diabetes Research Centre, Madras 600013, India Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1990) 78 (s22): 37P. https://doi.org/10.1042/cs078037P Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation P Gagjee, P Pemberton, R Lobley, C Chaloner, C Snehalatha, V Mohan, J Braganza; Preliminary Evaluation of Bt-Paba/Pas Test in Tropical Diabetes. Clin Sci (Lond) 1 January 1990; 78 (s22): 37P. doi: https://doi.org/10.1042/cs078037P Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1990 The Biochemical Society and the Medical Research Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Influence of Some 6-Methoxy-Aminobenzothiazole Derivatives on Corrosion of Ferrous and Nonferrous Metals Under Vapor-Phase Conditions (2003)

Use of vapor-phase corrosion inhibitors is one of the most effective methods for preventing atmospheric corrosion during transport and storage. In an attempt to develop multimetal vapor-phase corrosion inhibitors, five aminobenzothiazole derivatives were synthesized to investigate their inhibiting action on corrosion of mild steel, copper, and brass at 100% relative humidity by weight loss and potentiodynamic polarization methods. 6-methoxy-aminobenzothiazole cinnamate exhibited the best performance among all the studied compounds by giving &amp;gt;90% inhibition efficiency for all the metals investigated. All the inhibitors shifted corrosion potential of all metals significantly to the noble direction, indicating that they are predominantly anodic inhibitors.
Scaffolds for Cell and Tissue Engineering (2006)

Abstract The aim of tissue engineering is to combine the disciplines of engineering and biology to help the body's own regenerative mechanisms to repair diseased or damaged tissue to its original state and function. One strategy is to seed a patient's progenitor cells on a scaffold, which will act as a support and stimulus of tissue growth. The cells will lay down tissue in the shape of the scaffold and this biocomposite can be implanted into a defect with the scaffold dissolving as the tissue regenerates. Scaffold design is one of the important aspects of this strategy and will be discussed in this entry. The entry discusses the criteria for an ideal scaffold and the use of bioinert, bioresorble, and bioactive materials. The use of polymers, ceramics, glasses, and composites as scaffold materials and the processing techniques used to create tissue scaffolds are described and the advantages of using each material and each processing technique are discussed.
Figure S3 from Spatial Architecture and Arrangement of Tumor-Infiltrating Lymphocytes for Predicting Likelihood of Recurrence in Early-Stage Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Figure S3. Boxplots corresponding to the top SpaTIL features. (a) D1, (b) D2, (c) D3, and (d) D4.&lt;/p&gt;
Supplementary Figure Legend from Frequent Mutational Activation of the PI3K-AKT Pathway in Trastuzumab-Resistant Breast Cancer (2023)

&lt;p&gt;PDF file - 66K&lt;/p&gt;
Robust demarcation of 17 distinct Bacillus species clades, proposed as novel Bacillaceae genera, by phylogenomics and comparative genomic analyses: description of Robertmurraya kyonggiensis sp. nov. and proposal for an emended genus Bacillus limiting it only to the members of the Subtilis and Cereus clades of species (2020)

To clarify the evolutionary relationships and classification of <i>Bacillus</i> species, comprehensive phylogenomic and comparative analyses were performed on >300 <i>Bacillus/Bacillaceae</i> genomes. Multiple genomic-scale phylogenetic trees were initially reconstructed to identify different monophyletic clades of <i>Bacillus</i> species. In parallel, detailed analyses were performed on protein sequences of genomes to identify conserved signature indels (CSIs) that are specific for each of the identified clades. We show that in different reconstructed trees, most of the <i>Bacillus</i> species, in addition to the Subtilis and Cereus clades, consistently formed 17 novel distinct clades. Additionally, some <i>Bacillus</i> species reliably grouped with the genera <i>Alkalicoccus, Caldalkalibacillus, Caldibacillus, Salibacterium</i> and <i>Salisediminibacterium</i>. The distinctness of identified <i>Bacillus</i> species clades is independently strongly supported by 128 identified CSIs which are unique characteristics of these clades, providing reliable means for their demarcation. Based on the strong phylogenetic and molecular evidence, we are proposing that these 17 <i>Bacillus</i> species clades should be recognized as novel genera, with the names <i>Alteribacter</i> gen. nov.<i>, Ectobacillus</i> gen. nov., <i>Evansella</i> gen. nov.<i>, Ferdinandcohnia</i> gen. nov.<i>, Gottfriedia</i> gen. nov.<i>, Heyndrickxia</i> gen. nov.<i>, Lederbergia</i> gen. nov.<i>, Litchfieldia</i> gen. nov.<i>, Margalitia</i> gen. nov.<i>, Niallia</i> gen. nov.<i>, Priestia</i> gen. nov.<i>, Robertmurraya</i> gen. nov.<i>, Rossellomorea</i> gen. nov.<i>, Schinkia</i> gen. nov.<i>, Siminovitchia</i> gen. nov., <i>Sutcliffiella</i> gen. nov. and <i>Weizmannia</i> gen. nov. We also propose to transfer '<i>Bacillus kyonggiensi</i>s' to <i>Robertmurraya kyonggiensis</i> sp. nov. (type strain: NB22=JCM 17569<sup>T</sup>=DSM 26768). Additionally, we report 31 CSIs that are unique characteristics of either the members of the Subtilis clade (containing the type species <i>B. subtilis</i>) or the Cereus clade (containing <i>B. anthracis</i> and <i>B. cereus</i>). As most <i>Bacillus</i> species which are not part of these two clades can now be assigned to other genera, we are proposing an emended description of the genus <i>Bacillus</i> to restrict it to only the members of the Subtilis and Cereus clades.
High-average power, room temperature operation of PPMgLN OPO (2000)

In recent years, a 1mum DPSSL has achieved high power and highly efficient operation with good beam quality. This progress of DPSSL and improvement of the wavelength converter are expanding available wavelength range of solid state lasers.
[Vertigo in children]. (1994)

Oto-neurologic investigation in the child with vertigo is fundamentally important. In 3% of cases, it reveals the presence of a cerebral tumour. Technical difficulties in examining a child under 5 years of age stem from their fear of the dark, insecurity in a medical setting and a labile attention span. Major causes are migraine (in 28% of cases) and childhood idiopathic paroxysmal vertigo, and recurring vestibular disorders (13% of cases). Classic disorders such as Ménière's disease are rare in the child (3% of cases), as are benign paroxysmal positional vertigo and cupulolithiasis (only 5% of children with vertigo).
Studies on Glomerular Permeability Using Inert Polymers (2015)

Dextrans and other macromolecular inert polymers such as polyvinyl pyrrolidone fulfil all the criteria of an ideal test material for measuring glomerular permeability. Following a single intravenous injection of radioactively labelled polydisperse material serial plasma and urine samples can be analysed by gel filtration chromatography and the polymer fractionated into its constituent molecular sizes. Polymer of molecular size 24 A is capable of passing through the glomerulus as readily as water while material larger than 60 A is affectively excluded from the glomerular filtrate and one can determine the clearance of 20--30 intermediate molecular sized fractions. The accumulated data can be analysed by a number of different theoretical mathematical models; furthermore the technique can be employed in the study of proteinuria induced by vasoactive amines such as renin or angiotensin.