gebhart/patrepeval huggingface dataset:
Production of Naphthoquinone Mycotoxins and Taxonomy of Penicillium viridicatum (1981)

Groups I and II of Penicillium viridicatum were further differentiated on the basis of synthesis of two mycotoxins, xanthomegnin and viomellein. Strains previously classified as group II produced these pigments, whereas those in group I did not. These napthoquinone pigments were quantitated by thin-layer chromatography and high-pressure liquid chromatography. A new mobile phase of toluene and acetic acid effected a baseline separation of the two components. It is proposed that such biochemical distinctions be incorporated into an artificial taxonomic scheme of use to nontaxonomists.
Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. (1992)

We have shown that nontransformed mammalian cells arrest early in the G1 phase of the cell cycle when treated with exceedingly low concentrations of the nonspecific kinase inhibitor staurosporine, whereas transformed cells continue to progress through the cell cycle. We have now treated normal or transformed human skin fibroblasts with four other kinase inhibitors. Three of these inhibitors are highly specific: KT5720 inhibits cAMP-dependent protein kinase, KT5823 inhibits cGMP-dependent protein kinase, and KT5926 inhibits myosin light-chain kinase. The fourth inhibitor K252b has a moderate specificity for protein kinase C but also inhibits the three kinases just mentioned. We have found that these inhibitors reversibly arrest normal human skin fibroblasts at different times in the G1 phase but do not affect the cell cycle progression of transformed cells. The times of arrest within the G1 phase can be divided into two categories. Two of the inhibitors, KT5926 and K252b, act at an early time that is approximately 4 h after the transition from G0 to G1. The cAMP- and cGMP-dependent protein kinase inhibitors KT5720 and KT5823 arrest cells at a later time that is approximately 6 h after the G0/G1 boundary. These data indicate that there are multiple kinase-mediated phosphorylations of different substrates that are essential for the progression of normal cells, but not transformed cells, through the G1 phase. These inhibitors provide us with a set of biochemical probes that should be invaluable in the study of the function of kinases during G1 phase progression of normal cells.
Traumatic stress is linked to a deficit in associative episodic memory (2011)

Individuals with posttraumatic stress disorder (PTSD) are haunted by persistent memories of the trauma, but ironically are impaired in memories of daily life. The current set of 4 experiments compared new learning and memory of emotionally neutral content in 2 groups of patients and aged- and education-matched controls: 20 patients diagnosed with chronic posttraumatic stress disorder (C-PTSD) and 20 patients diagnosed with acute stress disorder (ASD). In all experiments, participants studied a list of stimuli pairs (words or pictures) and were then tested for their memory of the items, or for the association between items in each pair. Results indicated that both types of patients showed associative memory impairment compared to a control group, although their item memory performance was relatively intact. Potential mechanisms underlying such associative memory deficits in posttraumatic patients are discussed.
História e Violência: o caso da Migração para Rondônia (2004)

Este texto trata sobre a relação entre história e violência, bem como também analisa um caso concreto: a migração de luteranos para Rondônia. Os migrantes que compõem a análise desta pesquisa formam um grupo etnicamente coeso. Eles são capixabas descendentes dos pomeranos que migraram para Rondônia na década de 1970.
Molecular Networking Reveals Serpentinine-Related Bisindole Alkaloids from Picralima nitida, a Previously Well-Investigated Species (2020)

Five new monoterpene indole alkaloids (<b>1</b>-<b>5</b>), including four serpentinine-related bisindoles and one alstonine derivative monomer, have been isolated from the aerial parts of <i>Picralima nitida</i>. Their structures were elucidated by analysis of their HRMS and NMR spectroscopic data, and their absolute configurations were deduced from the comparison of experimental and simulated ECD spectra. In addition, two known compounds (<b>6</b> and <b>7</b>), previously undescribed from <i>P. nitida</i>, have also been purified. The compound isolation workflow was guided by a molecular networking-based dereplication strategy. Twenty-three compounds were dereplicated from the EtOH extract of <i>P. nitida</i> and fractions network and were assigned various levels of identification confidence. The antiparasitic activities against <i>Plasmodium falciparum</i> as well as the cytotoxic activity against the MRC-5 cell line were determined for compounds <b>1</b>-<b>7</b>.
Experiences of treating melanoma with vemurafenib at our institution and a discussion of its adverse effects (2016)

5例の転移性悪性黒色腫に対しvemurafenibを投与した。年齢は50歳から62歳（平均56.2±4.6歳），男性3例，女性2例，病型はsuperficial spreading melanoma（SSM）が4 例，acral lentigenous melanoma（ALM）が1例であった。効果はcomplete remission（CR）1例，stable disease（SD）2例，中止2例であった。Vemurafenibによる副作用として，QTc延長，薬疹，低K血症などがみられた。 特に，多彩な副作用を呈した1例の経験から，免疫チェックポイント阻害薬投与後のvemurafenibにより重症薬疹が出現しやすいこと，およびvemurafenibとステロイド中等量以上の併用においては，易感染性となる可能性があることを念頭に投与する必要があると考えた。
Applications of MIMO Techniques to Sensing of Cardiopulmonary Activity (2005)

Remote monitoring of cardiopulmonary activity based on Doppler shifts in radio signals shows promise in medical and security applications, however the problems of motion artifacts and presence of multiple subjects limit the usefulness of this technique. By applying MIMO signal processing, it is possible to overcome limitations of current systems and isolate signals from multiple sources.
Super-Resolution 3-D Laser Scanning Based on Interval Arithmetic (2020)

Most 3-D laser scanners are based on 3-D optical triangulation algorithms, where the location of each 3-D point is estimated as the intersection of a camera ray and a plane of light projected by a laser line generator. Since a physical laser-line generator projects a sheet of light of finite thickness, inaccurate measurements and errors result from assuming that the plane of light is infinitesimally thin. We propose a new mathematical formulation for 3-D optical triangulation based on interval arithmetic, where 3-D points are only determined within certain bounds along the camera rays, and multiple measurements are used to tighten these bounds. We propose the line segment cloud as an alternative surface representation to visualize the measurement errors within the proposed framework. We introduce the iterative line segment tightening algorithm to convert line segment clouds into point clouds, as a preprocessing step prior to surface reconstruction. We describe how to construct a low-cost laser-line 3-D scanner, where the camera is fixed with respect to the object and the laser-line generator is mounted on a high-resolution motion platform. We describe a GPU-based implementation where the large number of captured images is processed in real time. Finally, we present some experimental results.
Rheology of a twin liquid crystalline polymer (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRheology of a twin liquid crystalline polymerY. G. Lin, R. Zhou, J. C. W. Chien, and H. H. WinterCite this: Macromolecules 1988, 21, 7, 2014–2018Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/ma00185a022https://doi.org/10.1021/ma00185a022research-articleACS PublicationsRequest reuse permissionsArticle Views155Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Advancing sedation assessment to promote patient comfort. (2002)

As sedation assessment continues to evolve towards a more disciplined and standard part of clinical practice, the use of subjective sedation scales and objective sedation tools such as the BIS monitor continues to grow and show promise. The efforts of critical care nurses and their colleagues to better understand the value of these tools is integral to guiding their use and optimizing patient comfort.
Handbook of reactive chemical hazards (Bretherick, L.) (1980)

ADVERTISEMENT RETURN TO ISSUEPREVBook and Media Revie...Book and Media ReviewNEXTHandbook of reactive chemical hazards (Bretherick, L.)Clifford C. Houk Cite this: J. Chem. Educ. 1980, 57, 10, A295Publication Date (Print):October 1, 1980Publication History Received3 August 2009Published online1 October 1980Published inissue 1 October 1980https://doi.org/10.1021/ed057pA295.2RIGHTS & PERMISSIONSArticle Views223Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
β-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFκB and Nrf2/HO1/NQO1 Pathways (2022)

BCP administration was associated with activated Nrf2/HO1/NQO1 and inhibited TLR4/NFκB pathways with subsequent enhanced anti-oxidative capacity and diminished inflammatory and apoptosis responses.
Coumarin as dipolarophile towards 3,5‐dichloro‐2,4,6‐trimethylbenzonitrile oxide (1994)

Abstract The reaction of coumarin with the title nitrile oxide gives a single regioisomer in high yield. This result is compared with the dipolarophilic behavior of cinnamic acid esters.
Essentials of carbon-carbon composites (1993)

What are carbon-carbon composites and what do they offer, C. Thomas the importance of fibre type and fibre surface in controlling composite properties, E. Walker matrix precursors for carbon-carbon composites, B. Rand manufacturing considerations for carbon-carbon, R. Fisher multidirectional reinforced carbon-carbon, D. Cunningham and C. Thomas relationships between microstructure and mechanical properties in carbon-carbon composites, B. McEnaney and T. Mays mechanics of cracking in brittle matrix composites, L. McCartney the protection of carbon-carbon against oxidation, B. Bines.
Tuning Selective Transport of Biomolecules through Site-Mutated Nucleoporin-like Protein (NLP) Hydrogels (2021)

Natural selective filtering systems (e.g., the extracellular matrix, nuclear pores, and mucus) separate molecules selectively and efficiently, and the detailed understanding of transport mechanisms exploited in these systems provides important bioinspired design principles for selective filters. In particular, nucleoporins consist of consensus repeat sequences that are readily utilized for engineering repeat proteins. Here, the consensus repeat sequence of Nsp1, a yeast nucleoporin, is polymerized to form a nucleoporin-like protein (NLP) and mutated to understand the effect of sequence on selective transport. The hydrophilic spacers of the NLPs were redesigned considering net charge, charge distribution, and polarity. Mutations were made near to and far from the FSFG interacting domain to explore the role of highly conserved residues as a function of spatial proximity. A nuclear transport receptor-cargo complex, nuclear transport factor 2-green fluorescent protein (NTF2-GFP), was used as a model for changes in transport. For mutations of the charged spacer, some mutations of highly conserved charged residues were possible without knocking out selective transport of the NTF2, but the formation of regions of clustered negative charge has an unfavorable effect on nuclear transporter permeation. Thus, positive net charge and alternating positive and negative charge within the hydrophilic spacer are advantageous for recognition and selective transport. In the polarity panel, mutations that increased the interaction between NTF2-GFP and the gel led to decreased permeation of the NTF2-GFP due to blocking of the interface and inability of the NTF2-GFP to transport into the gel. Therefore, these results provide a strategy for tuning selective permeability of biomolecules using the artificially designed consensus repeat-based hydrogels.
Activation of Gq-Coupled Receptors in Astrocytes Restores Cognitive Function in Alzheimer’s Disease Mice Model (2023)

Alzheimer's disease (AD) is one of the most widespread neurodegenerative diseases. Most of the current AD therapeutic developments are directed towards improving neuronal cell function or facilitating Aβ amyloid clearance from the brain. However, some recent evidence suggests that astrocytes may play a significant role in the pathogenesis of AD. In this paper, we evaluated the effects of the optogenetic activation of Gq-coupled exogenous receptors expressed in astrocytes as a possible way of restoring brain function in the AD mouse model. We evaluated the effects of the optogenetic activation of astrocytes on long-term potentiation, spinal morphology and behavioral readouts in 5xFAD mouse model of AD. We determined that in vivo chronic activation of astrocytes resulted in the preservation of spine density, increased mushroom spine survival, and improved performance in cognitive behavioral tests. Furthermore, chronic optogenetic stimulation of astrocytes resulted in the elevation of EAAT-2 glutamate uptake transporter expression, which could be a possible explanation for the observed in vivo neuroprotective effects. The obtained results suggest that the persistent activation of astrocytes may be considered a potential therapeutic approach for the treatment of AD and possibly other neurodegenerative disorders.
Distinct protein expression and activity of transglutaminases found in different epidermal tumors (2014)

We investigated protein expression and in situ activity of transglutaminases (TGs) in normal skin and various epidermal neoplasms. In normal skin, TG1 protein expression and TG activity were found at keratinocyte cell membranes in upper epidermis and granular layer, respectively. In seborrhoeic keratosis, TG1 protein was expressed evenly throughout tumors, while TG activity increased in gradient fashion from lower tumor area to cornified layer. In squamous cell carcinoma, TG1 protein was expressed at inner side of cell membranes, whereas TG activity was found in cytoplasm predominantly at horn pearls. In basal cell carcinoma, weak TG activity was found in cytoplasm of all tumor cells without the presence of TG1 protein. Immunoblotting and in situ activity assays using specific substrate peptides confirmed that TG2, but not TG1, contributed to the TG activity. These results suggested that different expression and activation of TGs may contribute to characteristics of the skin tumors.
<title>Application of CO laser for frequency-selective surface heat treatment of polymer materials</title> (1998)

Frequency selected Q-switched e-beam controlled-discharge CO- laser has been researched and developed for surface heat treatment of polymeric materials [poly(ethyleneterephthalate) and nylon] having strong absorption bands near wavelength of approximately 6 micrometer. The laser generates pulses (including short ones with duration (tau) <SUB>0.1</SUB> approximately 1 - 10 microsecond(s) ) having different spectral content within 4.9 - 6.5 micrometer spectral range. Different geometry and methods of irradiation were used to process samples with the laser radiation of different temporal, spectral and energy density characteristics. Different types of microstructure were formed on the surfaces of the samples. Experimental conditions corresponding to each type of microstructure were defined. Visual (macro) changes of polymeric material properties (if any) and their correlation with formed microstructures were analyzed.
Sparing radiation‐induced damage to the physis by radioprotectant drugs: Laboratory analysis in a rat model (1999)

The radioprotectant compound amifostine (S-2[3-aminopropylamino]-ethylphosphorothioic acid), administered prior to radiotherapy, has been demonstrated to provide differential protection of normal cells from the damaging effects of ionizing radiation. The aim of this pilot was to determine if amifostine could preserve the integrity of, or minimize the damage to, the physis during exposure to radiation in an animal model. Thirty weanling Sprague-Dawley rats were randomized into five groups of six animals each. Groups 1 and 2 received a single exposure to radiation consisting of 12.5 and 17.5 Gy, respectively. Groups 3 and 4 received similar exposures of 12.5 and 17.5 Gy, respectively, but with prior administration of amifostine at 100 mg/kg. Group 5 (control) received neither radiation nor amifostine. At 6 weeks, femoral and tibial lengths were measured in treated and untreated hindlimbs and compared with the baseline lengths to calculate growth. Concordant with previous reports in the literature, the radiation doses of 12.5 and 17.5 Gy reduced net femoral growth in length by a mean of 23% (range = 12-33%, SD = 7.41) and 59% (range = 54-64%, SD = 4.45), respectively, in the irradiated limb. Amifostine reduced anticipated growth loss normally resulting from a single 12.5-Gy radiation dose by 48.9% in the femur, 13.1% in the tibia, and 27.6% overall in the total limb (p < or = 0.05). Similarly, anticipated growth loss from a single 17.5-Gy radiation dose was reduced by 30.8% in the femur, 20.3% in the tibia, and 25.7% overall in the total limb (p < or = 0.05). Amifostine administered prior to clinically relevant radiation exposures significantly reduced the amount of anticipated growth arrest in our animal model.
Recognition of 3D package shapes for single camera metrology (2014)

Many applications of 3D object measurement have become commercially viable due to the recent availability of low-cost range cameras such as the Microsoft Kinect. We address the application of measuring an object's dimensions for the purpose of billing in shipping transactions, where high accuracy is required for certification. In particular, we address cases where an object's pose reduces the accuracy with which we can estimate dimensions from a single camera. Because the class of object shapes is limited in the shipping domain, we perform a closed-world recognition in order to determine a shape model which can account for missing parts, and/or to induce the user to reposition the object for higher accuracy. Our experiments demonstrate that the addition of this recognition step significantly improves system accuracy.
Supplementary Table TS1 from Targeting NEDDylation is a Novel Strategy to Attenuate Cisplatin-induced Nephrotoxicity (2023)

&lt;p&gt;Genes altered by 2 fold change or more by pevonedistat treatment.&lt;/p&gt;
A genomic classifier to improve prediction of metastatic disease within 5 years after surgery in node-negative high-risk prostate cancer patients managed by radical prostatectomy without adjuvant therapy. (2015)

154 Background: Surgery is a standard first line therapy for most intermediate-high risk men diagnosed with prostate cancer. While clinical factors such as tumor grade, stage and prostate specific antigen (PSA) are currently used to identify patients at risk of cancer recurrence, novel biomarkers that can improve risk stratification and distinguish local from systemic recurrence are needed. The Decipher Genomic Classifier (GC) is a validated model for predicting men at risk of metastasis. We evaluated its performance in predicting metastatic disease within 5 years after surgery (rapid metastasis, RM) in an independent cohort. Methods: Tumors and clinicopathologic data were obtained from a cohort of 2,641 RP patients treated between 1987-2008 at Cleveland Clinic. The final study cohort consisted of 15 RM patients and 154 patients as non-RM controls who met the following criteria: 1) preoperative PSA&gt;20 ng/mL, stage pT3 or margin positive, or Gleason score ≥8; 2) pathologic node negative; 3) undetectable post-RP PSA; 4) no neoadjuvant or adjuvant therapy; and 5) minimum 5 year follow-up for the controls. Results: RM patients developed metastasis with a median of 2.3 (IQR: 0.8-5) years. In multivariable analysis, GC was a significant predictor of RM (OR=1.48, p=0.018) after adjusting for clinical risk factors. GC had the highest c-index, 0.77, compared to the Stephenson model (c-index 0.75) and CAPRA-S (c-index 0.72) as well as a panel of previously reported prostate cancer biomarkers unrelated to GC. Integration of GC into the Stephenson nomogram increased the c-index from 0.75 (95% CI: 0.65-0.85) to 0.79 (95% CI: 0.68-0.89). Conclusions: GC was independently validated as a genomic metastasis signature for predicting RM in a cohort of high-risk men treated with RP and managed conservatively without any adjuvant therapy. Integration of GC into clinical nomograms led to improvement in prediction of RM. GC may further allow identification of men most at risk for metastatic progression who should be considered for multimodal therapy or inclusion in clinical trials.