gebhart/patrepeval huggingface dataset:
Substrate specificity of citrus alcohol: NAD oxidoreductase (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstrate specificity of citrus alcohol: NAD oxidoreductaseJoseph H. Bruemmer and Bongwoo. RoeCite this: J. Agric. Food Chem. 1971, 19, 2, 266–268Publication Date (Print):March 1, 1971Publication History Published online1 May 2002Published inissue 1 March 1971https://pubs.acs.org/doi/10.1021/jf60174a019https://doi.org/10.1021/jf60174a019research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ultrahigh and persistent optical depths of alkali vapours for quantum memories in hollow-core photonic crystal fibers (2016)

We show the highest (&gt;105) and longest-lived (&gt;3 hours) optical depths of alkali vapours in hollow-core photonic crystal fibres, which we will use to implement a novel noiseless broadband quantum memory scheme for temporal multiplexing.
Video-rate volume imaging confocal microscope based on wavelength / space conversion by use of multichannel spectrometer (2016)

Video-rate volume imaging confocal microscopy employing line-focused confocal microscopy, wavelength/1D-space conversion and a PZT objective scanner was proposed. The system enables 1.4 volumes/s (13 slices) with the axial resolution of 8.4 µm.
REVIEW ON COMPUTATIONAL EXPLOSION MECHANICS (2012)

Exact solution of explosion problem cannot be achieved in most cases because of its strong nonlinearity. And data gained from experiments are very limited because explosion is a strong physical course finished in short duration.Simulation of explosion mechanics and related research has greatly promoted rapid development of both explosion mechanics and weaponry.This paper mainly reviews on explosion mechanics, dynamic constitutive model of material and related engineering applications.
Heterogeneity of the hypoxic state in rat heart is determined at capillary level (1993)

Heterogeneity in the hypoxic state of Tyrode-perfused rat hearts was studied using NADH and Pd-porphine videofluorometry. Ischemic as well as high-flow anoxia resulted in a homogeneous rise of tissue NADH fluorescence, whereas normoxic recovery from both types of anoxia caused transiently persisting patchy fluorescent areas. Patterns were always the same for a given heart. PO2 distribution in the vasculature measured by Pd-porphine phosphorescence showed patterns similar to the NADH fluorescence patterns. Microsphere embolization of the capillaries, but not of arterioles, elicited identical NADH fluorescence patterns as seen during recovery from anoxia without microspheres. High heartbeat rates also caused patchy fluorescent areas but not in the presence of adenosine. Patterns corresponded to those seen during normoxic recovery from anoxia under low beat rates. It is concluded that there are circulatory units in the rat heart at the capillary level that result in the temporary persistence of anoxic areas during recovery from anoxia. These vulnerable areas are the first to be compromised during high heartbeat rates.
FIBROMYALGIA: WHAT IT IS AND HOW IT RELATES TO OTHER UNEXPLAINED ILLNESSES* (2009)

Fibromyalgia (FM), which primarily affects women, is one of several medically unexplained illnesses. In many instances, FM is accompanied by one or more of these illnesses, which often confounds the approach to diagnosis and treatment. Although the pain and tenderness of FM are very real, many patients seen in the primary care setting are not taken seriously and do not receive appropriate treatment. However, the equation has changed with the recent approval of 3 drugs for FM. This article describes FM, reviews the evidence supporting FM as a chronic central pain state (as opposed to a rheumatologic disorder), and explains how FM relates to other medically unexplained illnesses. The article also presents an algorithm for the treatment of FM in clinical practice. (Adv Stud Pharm. 2009;6(5):134-139)
Replication data for: Andreev Modes from Phase Winding in a Full-shell Nanowire-based Transmon (2020)

Replication data for: Andreev Modes from Phase Winding in a Full-shell Nanowire-based Transmon
Comparison of Intraprostatic Ethanol Diffusion Using a Microporous Hollow Fiber Catheter Versus a Standard Needle (2012)

Improved distribution and absent backflow were seen when using the microporous hollow fiber catheter, supporting its potential as a new method to treat prostate disease.
Effect of hyperthermia and chemotherapeutic agents on TRAIL‐induced cell death in human colon cancer cells (2007)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent because of its tumor selectivity. TRAIL is known to induce apoptosis in cancer cells but spare most normal cells. In the previous study [Yoo and Lee, 2007], we have reported that hyperthermia could enhance the cytotoxicity of TRAIL-induced apoptosis. We observed in human colorectal cancer cell line CX-1 that TRAIL-induced apoptotic death and also that mild hyperthermia promoted TRAIL-induced apoptotic death through caspase activation and cytochrome-c release. Although its effects in vivo are not clear, hyperthermia has been used as an adjunctive therapy for cancer. Hyperthermia is often accompanied by chemotherapy to enhance its effect. In this study, CX-1 colorectal adenocarcinoma cells were treated with TRAIL concurrently with hyperthermia and oxaliplatin or melphalan. To evaluate the cell death effects on tumor cells via hyperthermia and TRAIL and chemotherapeutic agents, FACS analysis, DNA fragmentation, and immunoblottings for PARP-1 and several caspases and antiapoptotic proteins were performed. Activities of casapse-8, caspase-9, and caspase-3 were also measured in hyperthermic condition. Interestingly, when analyzed with Western blot, we detected little change in the intracellular levels of proteins related to apoptosis. Clonogenic assay shows, however, that chemotherapeutic agents will trigger cancer cell death, either apoptotic or non-apoptotic, more efficiently. We demonstrate here that CX-1 cells exposed to 42 degrees C and chemotherapeutic agents were sensitized and died by apoptotic and non-apoptotic cell death even in low concentration (10 ng/ml) of TRAIL.
[5-Fluoro-2-(4-methylbenzoyloxy)phenyl](4-methylphenyl)methanone (2006)

In the title compound, C22H17FO3, there are weak inter­molecular C—H⋯O hydrogen bonds resulting in the formation of a polymeric chain.
Synthesis and Trimethylaluminum Additions on γ‐Hydroxy‐δ‐sulfinyl and Sulfonyl Enoates. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Swarm bias-variance analysis of an evolutionary neural network classifier (2006)

In the search of a system satisfying all the requirements of an automated classifier, evolutionary artificial neural networks have been successfully applied to a number of problems, in particular to problems where there is not a deep knowledge of the phenomena and other methods tend to fail. There are many neural models that efficiently solve either function approximation problems in general terms or some particular problems like classification, pattern recognition, clustering and time-series prediction. This success is due to these models main characteristics, in particular those matching the essentials for an automated classifier: keeping bias and variance low. This paper presents a classifier system based on the benefits arising from the interaction between evolutionary algorithms, such as particle swarm optimization, and artificial neural networks. And a bias variance decomposition of the predictive error shows that the success of the proposed approach lies in the ability of the learning algorithm to properly tune the bias/variance trade-off to reduce the prediction error. To measure the performance, the porposed classifier will be tested on three different well known benchmark problems: the Fisher Iris data set, the Australian credit card assessment and the Pima diabetes data set.
Role of superhelicity in homologous pairing of DNA molecules promoted by Escherichia coli recA protein. (1982)

In the presence of ATP and an excess of recA protein, superhelical closed circular DNA (form I DNA) and homologous single-stranded fragments paired to form D-loops in the early stage of incubation and dissociated during subsequent incubation. RecA protein that was not bound to single-stranded DNA ("free recA protein") was shown to be responsible for the dissociation of D-loops. Larger amount of free recA protein gave a lower final yield of D-loops. When the concentration of form I DNA was increased in the presence of a fixed amount of single-stranded DNA, larger amounts of free recA protein were required to produce a certain extent of dissociation. When form I DNA, excess recA protein, and ATP were incubated without single-stranded DNA, or with heterologous single-stranded fragments before the addition of homologous single-stranded fragments, formation and subsequent dissociation of D-loops were observed as in the case when all components of the reaction were added from the start. Therefore, the dissociation of D-loops is a result of the stoichiometric interaction between free recA protein and form I DNA bearing D-loops. In the process of formation and dissociation of D-loops, form I DNA was converted to an inactive substrate without any apparent damage to the DNA. The concentration of free recA protein appeared to decrease during the reaction. These observations revealed that formation and dissociation of D-loops are sequential reactions when form I DNA is the substrate and recA protein is present in excess. The dissociation of D-loops and the inactivation of form I DNA can be explained by a model in which recA protein cooperatively binds to form I DNA from the site of D-loop, resulting in stimulation of unidirectional unwinding of the double helix.
Using neural networks for prediction of the subcellular location of proteins (1998)

Neural networks have been trained to predict the subcellular location of proteins in prokaryotic or eukaryotic cells from their amino acid composition. For three possible subcellular locations in prokaryotic organisms a prediction accuracy of 81% can be achieved. Assigning a reliability index, 33% of the predictions can be made with an accuracy of 91%. For eukaryotic proteins (excluding plant sequences) an overall prediction accuracy of 66% for four locations was achieved, with 33% of the sequences being predicted with an accuracy of 82% or better. With the subcellular location restricting a protein's possible function, this method should be a useful tool for the systematic analysis of genome data and is available via a server on the world wide web.
Postural orthostatic tachycardia syndrome is an under-recognized condition in chronic fatigue syndrome (2008)

POTS is a frequent finding in patients with CFS/ME. We suggest that clinical evaluation of patients with CFS/ME should include response to standing. Studies are needed to determine the optimum intervention strategy to manage POTS in those with CFS/ME.
Effects of the cationic protein poly‐L‐arginine on airway epithelial cells in vitro (2002)

The results point to poly-L-arginine induced membrane damage, resulting in increased permeability, loss of cell-cell contacts and generalized cell damage.
Coverage Analysis In Downlink Poisson Cellular Network With κ-μ Shadowed Fading (2016)

The downlink coverage probability of a cellular network, when the base station locations are modeled by a Poisson point process, is known when the desired channel is Nakagami distributed with an integer shape parameter. However, for many interesting fading distributions such as Rician, Rician shadowing, κ-μ, η-μ, etc., the coverage probability is unknown. κ-μ shadowed fading is a generic fading distribution whose special cases are many of these popular distributions known so far. In this letter, we derive the coverage probability when the desired channel experiences κ-μ shadowed fading. Using numerical simulations, we verify our analytical expressions.
Distributed Queue-Based Locking Using Advanced Network Features (2005)

A distributed lock manager (DLM) provides advisory locking services to applications such as databases and file systems that run on distributed systems. Lock management at the server is implemented using first-in-first-out (FIFO) queues. In this paper, we demonstrate a novel way of delegating the lock management to the participating lock-requesting nodes, using advanced network primitives such as remote direct memory access (RDMA) and atomic operations. This nicely complements the original idea of DLM, where management of the lock space is distributed. Our implementation achieves better load balancing, reduction in server load and improved throughput over traditional designs.
Effects of Preview Time on Human Control Behavior in Rate Tracking Tasks (2016)

In many practical control tasks, human controllers (HC) can preview the trajectory they must follow in the near future. This paper investigates the effects of the length of previewed target trajectory, or preview time, on HC behavior in rate tracking tasks. To do so, a human-in-the-loop experiment was performed, consisting of a combined target-tracking and disturbance-rejection task. Between conditions the preview time was varied between 0, 0.1, 0.25 0.5 0.75 or 1 s, capturing the complete human control-behavioral adaptation from zero- to full-preview tasks, where the performance remains constant. The measurements were analyzed by fitting a HC model for preview tracking tasks to the data. Results show that optimal performance is attained when the displayed preview time is higher than 0.5 s. When the preview time increases, subjects exhibit more phase lead in their target response dynamics. They respond to a single point on the target ahead when the preview time is below 0.5 s and generally to two different points when more preview is displayed. As the model tightly fits to the measurement data, its validity is extended to different preview times
Abstract LB-384: A-to-I miR-378a-3p editing prevents melanoma progression via regulation ofPARVA expression (2018)

Abstract Although recent studies have shown that adenosine-to-inosine (A-to-I) RNA editing occurs in microRNAs (miRNAs), the effects of A-to-I miRNAs editing on melanoma growth and metastasis are yet to be determined. Previously we have reported that metastatic melanoma cell lines and tumor specimens have reduced expression of ADAR1 and consequently are impaired in their ability to perform A-to-I microRNA (miRNA) editing. Here we report that miR-378a-3p is undergoing A-to-I editing only in the non-metastatic but not in metastatic melanoma cells. The function of the edited form is different from its wild-type counterpart. The edited form of miR-378a-3p preferentially binds to the 3'UTR of the PARVA oncogene and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype. Indeed, edited miR- 378a-3p but not its WT form inhibits melanoma metastasis in vivo. These results further emphasize the role of RNA editing in melanoma progression. Citation Format: Einav Shoshan, Guermarie Velazquez-Torres, Enrique Fuentes-Mattei, Cristina Ivan, Menashe Bar-Eli. A-to-I miR-378a-3p editing prevents melanoma progression via regulation ofPARVA expression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr LB-384.
A critical review of anagrelide therapy in essential thrombocythemia and related disorders (2005)

Thrombocytosis is a common clinical problem and it represents either a primary myeloid disorder (a clonal process) or a reactive phenomenon. While reactive thrombocytosis is often inconsequential, clonal thrombocytosis may require cytoreductive therapy to prevent thrombohemorrhagic complications. In this regard, a controlled clinical trial has previously demonstrated the efficacy of hydroxyurea in reducing the risk of thrombosis in high-risk patients with essential thrombocythemia (ET). Despite the absence of similar evidence for clinical benefit, the platelet-lowering agent anagrelide has been widely used in both ET and polycythemia vera (PV) and recent reports of serious side-effects suggest that such practice might be detrimental to patients. In the current review we provide basic drug information as well as a critical assessment of anagrelide treatment in ET and related disorders.
A prospective randomized trial examining health care utilization in individuals using multiple smartphone-enabled biosensors (2016)

Background. Mobile health and digital medicine technologies are becoming increasingly used by individuals with common, chronic diseases to monitor their health. Numerous devices, sensors, and apps are available to patients and consumers-some of which have been shown to lead to improved health management and health outcomes. However, no randomized controlled trials have been conducted which examine health care costs, and most have failed to provide study participants with a truly comprehensive monitoring system. Methods. We conducted a prospective randomized controlled trial of adults who had submitted a 2012 health insurance claim associated with hypertension, diabetes, and/or cardiac arrhythmia. The intervention involved receipt of one or more mobile devices that corresponded to their condition(s) (hypertension: Withings Blood Pressure Monitor; diabetes: Sanofi iBGStar Blood Glucose Meter; arrhythmia: AliveCor Mobile ECG) and an iPhone with linked tracking applications for a period of 6 months; the control group received a standard disease management program. Moreover, intervention study participants received access to an online health management system which provided participants detailed device tracking information over the course of the study. This was a monitoring system designed by leveraging collaborations with device manufacturers, a connected health leader, health care provider, and employee wellness program-making it both unique and inclusive. We hypothesized that health resource utilization with respect to health insurance claims may be influenced by the monitoring intervention. We also examined health-self management. Results & Conclusions. There was little evidence of differences in health care costs or utilization as a result of the intervention. Furthermore, we found evidence that the control and intervention groups were equivalent with respect to most health care utilization outcomes. This result suggests there are not large short-term increases or decreases in health care costs or utilization associated with monitoring chronic health conditions using mobile health or digital medicine technologies. Among secondary outcomes there was some evidence of improvement in health self-management which was characterized by a decrease in the propensity to view health status as due to chance factors in the intervention group.
Adaptive Movable Neural Interfaces for Monitoring Single Neurons in the Brain (2011)

Implantable microelectrodes that are currently used to monitor neuronal activity in the brain in vivo have serious limitations both in acute and chronic experiments. Movable microelectrodes that adapt their position in the brain to maximize the quality of neuronal recording have been suggested and tried as a potential solution to overcome the challenges with the current fixed implantable microelectrodes. While the results so far suggest that movable microelectrodes improve the quality and stability of neuronal recordings from the brain in vivo, the bulky nature of the technologies involved in making these movable microelectrodes limits the throughput (number of neurons that can be recorded from at any given time) of these implantable devices. Emerging technologies involving the use of microscale motors and electrodes promise to overcome this limitation. This review summarizes some of the most recent efforts in developing movable neural interfaces using microscale technologies that adapt their position in response to changes in the quality of the neuronal recordings. Key gaps in our understanding of the brain-electrode interface are highlighted. Emerging discoveries in these areas will lead to success in the development of a reliable and stable interface with single neurons that will impact basic neurophysiological studies and emerging cortical prosthetic technologies.
Accurate calculation of eye diagrams and bit error rates in optical transmission systems using linearization (2002)

We present a novel linearization method to calculate accurate eye diagrams and bit error rates (BERs) for arbitrary optical transmission systems and apply it to a dispersion-managed soliton (DMS) system. In this approach, we calculate the full nonlinear evolution using Monte Carlo methods. However, we analyze the data at the receiver assuming that the nonlinear interaction of the noise with itself in an appropriate basis set is negligible during transmission. Noise-noise beating due to the quadratic nonlinearity in the receiver is kept. We apply this approach to a highly nonlinear DMS system, which is a stringent test of our approach. In this case, we cannot simply use a Fourier basis to linearize, but we must first separate the phase and timing jitters. Once that is done, the remaining Fourier amplitudes of the noise obey a multivariate Gaussian distribution, the timing jitter is Gaussian distributed, and the phase jitter obeys a Jacobi-/spl Theta/ distribution, which is the periodic analogue of a Gaussian distribution. We have carefully validated the linearization assumption through extensive Monte Carlo simulations. Once the effect of timing jitter is restored at the receiver, we calculate complete eye diagrams and the probability density functions for the marks and spaces. This new method is far more accurate than the currently accepted approach of simply fitting Gaussian curves to the distributions of the marks and spaces. In addition, we present a deterministic solution alternative to the Monte Carlo method.