gebhart/patrepeval huggingface dataset:
Clinical characteristics of patients with non-small cell lung cancer eligible for biology-guided radiotherapy. (2023)

e20523 Background: Biology-guided radiotherapy (BgRT) is a novel radiotherapy modality that uses real-time positron emission tomography (PET) to guide radiotherapy beamlets. BgRT recently received FDA clearance for clinical use using the 18F FDG radiotracer for the treatment of tumors in lung and bone. We sought to identify non-small cell lung cancer (NSCLC) patients who may be candidates for BgRT based on diagnostic FDG PET/CT imaging. Methods: We conducted an IRB-approved retrospective assessment of NSCLC patients diagnosed between 01/01/2006 and 12/31/2013 at a tertiary care center in the United States. Patient and tumor characteristics were verified by an institutional data repository team and through electronic medical record review. Patients were excluded from analysis when documentation of clinical/ imaging findings was insufficient. Frequency of characteristics were interpreted with and without tumor diameter and maximum standardized uptake value (SUV Max ) parameters, to confirm eligibility for BgRT on this novel radiotherapy device. Results: Of the 686 patients eligible for analysis, 523 presented with tumor SUV Max of ≥6 on diagnostic PET imaging and 360 presented with tumor diameters of at least 2 cm and below 5 cm. Of the 277 patients who met both SUV Max and size parameters, respectively, 75 (27.1%), 145 (52.3%), and 57 (20.6%) presented with squamous, adenocarcinoma, or other/unknown histology, and 77 (27.9%), 29 (10.5%), 92 (33.3%), and 78 (28.3%) presented with stage I, II, III, or IV tumors (AJCC 7 th edition). Conclusions: Theoretical applicability of biology-guided radiotherapy was observed in our NSCLC patient cohort. Therefore, despite current limitations of radiotracer uptake thresholds and tumor size restrictions, there is broad potential applicability of this treatment modality, either as a single modality treatment or in conjunction with active systemic therapy. [Table: see text]
Simple physical models for coulomb‐induced frequency shifts and coulomb‐induced inhomogenous broadening for like and unlike ions in fourier transform ion cyclotron resonance mass spectrometry (1991)

Abstract Two simple models which Correspond more closely to physical reality than some prior models are proposed to account for the Coulomb‐induced frequency shifts to lower frequency, Which have been observed in Fourier transform ion cyclotron resonance (FT‐ICR) mass spectrometry. The first model consists of two different‐mass point charges which undergo cyclotron orbits with the same orbit centers at their respective cyclotron frequencies. The model predicts that each excited cyclotron motion should induce a negative frequency shift in the other's cyclotron motion. The model predicts a zero frequency shift for ions of the same mass. The physical basis for the Coulomb‐induced shift is most easily seen in a coordinate frame which rotates at the cyclotron motion of the ion whose frequency is shifted. It is noted that a prior model for Coulomb‐induced frequency shifts is more appropriate for scanning ICR than FT‐ICR and the reason is described for the correctness of the predictions of this less appropriate model. A second model, the line model, is created by extension of the point model. The line model gives rise to a position‐dependent frequency shift which is synonymous with inhomogeneous Coulomb broadening. When a non‐quadrupolar electrostatic trapping field is included in the model, ‘like’ ions become ‘unlike’ and Coulomb‐shifting and Coulomb‐broadening apply, as for ‘like’ ions. The analysis predicts that ICR cells which are designed to have negligible trapping fields over most of their volume will be less sensitive to Coulomb shifting/broadening than ordinary ICR cells.
Investigating the Size-Dependent Static and Dynamic Behavior of Circular Micro-Plates Subjected to Capillary Force (2015)

The size-dependent static deflection, pull-in instability and resonant frequency of a circular microplate under capillary force have been studied using modified couple stress elasticity theory. Size-dependency is a phenomenon in which the normalized quantities that classical elasticity theory predicts to be independent of the structure size, such as normalized deflection or normalized frequency, vary significantly as the structure size changes. This phenomenon has been observed in micro-scale structures such as micro-electro-mechanical-systems (MEMS). Since classical elasticity theory is unable to predict the size-dependency, non-classical elasticity theories such as modified couple stress theory have been developed recently. In this paper, modified couple stress theory is used for the first time to develop the governing equation and boundary conditions of circular microplates when subjected to capillary force. Consideration of capillary force is important since it is has a significant role in the mechanical behavior and stability of micro-scale structures in the presence of a liquid bridge. We investigated the static deflection and pull-in instability of microplates using the Galerkin method to assess the effect of size-dependency for static deflection. We observed that, as the ratio of the microplate thickness to length scale parameter (an additional material property suggested in modified couple stress theory to capture the size-dependency) decreases, the normalized deflection of the microplate also decreases. We further observed that the difference between the normalized deflection predicted by classical elasticity theory and the one evaluated using modified couple stress theory is significant when thickness of the microplate is small, but diminishes as thickness increases. Furthermore, we defined a dimensionless number called the dimensionless capillary tension (DCT) as a function of the mechanical, geometrical and size-dependent properties of the microplate as well as the characteristics of the liquid bridge such as the contact angle and the interfacial tension. We showed that for DCT values greater than a threshold evaluated in this paper, pull-in instability happens and the microplate collapses to the substrate. Moreover, we evaluated the size-dependent resonant frequency of the microplate under capillary force as a function of the DCT and obtained the result that the frequency decreases as DCT increases. In addition, our investigation of size-dependency revealed that as the ratio of the microplate thickness to length scale parameter increases, the frequency decreases in a way that for large values of the ratio, it asymptotically approaches the value predicted by classical elasticity theory.
Abstract P4-02-07: Lasofoxifene as a potential treatment for aromatase inhibitor resistant ER positive breast cancer (2022)

Abstract Postmenopausal patients with estrogen receptor positive (ERα+) primary invasive breast cancer are typically treated with aromatase inhibitors (AIs) as first line adjuvant therapy. Patients who become resistant to AIs are treated with fulvestrant and/or CDK4/6 inhibitors, such as palbociclib, as second line therapy. Lasofoxifene, a selective estrogen receptor modulator (SERM), was developed for the treatment of vaginal atrophy and osteoporosis. Our previous studies, performed in an MCF-7 xenograph metastatic breast cancer mouse model with activating ERα mutations, showed that lasofoxifene, both alone and in combination with palbociclib, was more effective than fulvestrant at inhibiting tumor growth and metastasis to the liver, lung, bone and brain. In the current study, we compared the efficacy of lasofoxifene +/- palbociclib to fulvestrant +/- palbociclib combinations in a letrozole-induced, AI-resistant breast tumor model (MCF-7 LTLT cells) that does not express ERα activating mutations. Luciferase-GFP tagged LTLT cells were injected into the mammary ducts of NSG mice (MIND model) and tumor progression was monitored by live luminescence imaging of primary tumors, as well as ex vivo imaging and histochemical analysis of metastatic sites at study endpoint. Primary tumor area was also measured at study endpoint. Lasofoxifene +/- palbociclib was significantly more effective than fulvestrant +/- palbociclib at inhibiting primary tumor growth. In addition, all treatments, except fulvestrant, inhibited bone metastasis versus vehicle. These data show that lasofoxifene is more effective than fulvestrant in this tumor model and suggest that lasofoxifene has potential as an effective therapy for AI resistant breast cancers that do not express ERα activating mutations. Citation Format: Muriel Laine, Marianne E Greene, Tiffany Leng, Justyna D Kurleto, Sophia Li, Barry Komm, Geoffrey L Greene. Lasofoxifene as a potential treatment for aromatase inhibitor resistant ER positive breast cancer [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P4-02-07.
Generation of Solitons and Platicons in Optical Microresonators with Backscattering (2020)

We study the influence of backscattering on generation and properties of dissipative Kerr solitons and platicons in high-Q optical microresonators. We show that interaction of the forward and backward waves can significantly modify existence and stability domains of the solitonic pulses.
Well-characterized olefin metathesis catalysts that contain molybdenum (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTWell-characterized olefin metathesis catalysts that contain molybdenumJohn S. Murdzek and Richard R. SchrockCite this: Organometallics 1987, 6, 6, 1373–1374Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/om00149a048https://doi.org/10.1021/om00149a048research-articleACS PublicationsRequest reuse permissionsArticle Views1140Altmetric-Citations170LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DDRE-10. IMMUNE PROFILES ASSOCIATE WITH OUTCOMES IN HLA-A*02:01+, H3.3K27M+ PATIENTS WITH DIFFUSE MIDLINE GLIOMAS TREATED WITH H3.3K27M PEPTIDE VACCINE COMBINED WITH POLY-ICLC: A PNOC REPORT (2020)

Abstract BACKGROUND Patients with diffuse midline gliomas (DMG), including diffuse intrinsic pontine glioma (DIPG), have dismal outcomes. We previously described the H3.3K27M mutation as a shared neoantigen in HLA-A*02.01+ H3.3K27M+ DMGs. Within the Pacific Pediatric Neuro-Oncology Consortium, we assessed the safety and efficacy of an H3.3K27M-targeted peptide vaccine. PATIENTS AND METHODS Newly diagnosed patients aged 3–21 years with positive HLA-A*02.01+ and H3.3K27M+ status were enrolled into two strata after completion of radiation therapy: Stratum A for DIPG (n=19); Stratum B for non-pontine DMG (n=10). Vaccine was administered in combination with poly-ICLC every three weeks for eight cycles, followed by once every six weeks. Immunological responses were assessed in peripheral blood mononuclear cells using mass cytometry. RESULTS 19 patients enrolled in Stratum A (median age=11 years) and 10 in Stratum B (median age=13 years). There were no grade 4 treatment-related adverse events (TRAE). Injection site reaction was the most commonly reported TRAE. Overall survival (OS) at 12 months was 40% (95% CI, 22% to 73%) for Stratum A and 39% (95% CI, 16% to 93%) for Stratum B. The median OS was 16.1 months in patients exhibiting an expansion of H3.3K27M-reactive CD8+ T-cells compared to 9.8 months for their counterparts (p=0.05). DIPG patients with below-median baseline levels of myeloid-derived suppressor cells had prolonged OS compared to their counterparts (p&amp;lt; 0.1). Immediate pre-treatment dexamethasone administration inversely associated with H3.3K27M-reactive CD8+ T-cell responses. However, neither tumor size or bulk CD8+ T-cell status was significantly associated with OS. CONCLUSION Administration of the H3.3K27M-specific vaccine is well tolerated. Patients with H3.3K27M-specific CD8+ immunological responses demonstrated prolonged OS compared to non-responders.
Exploring silicon oxycarbide films for photonic waveguides (2018)

Silicon oxycarbide thin films deposited with reactive rf magnetron sputtering are exploited to fabricate photonics waveguides with two high refractive indices of 1.58 and 1.82 exhibiting index contrast of 8% and 18% with silica glass. The propagation losses are estimated in the telecom wavelength range and the results demonstrate the potential of silicon oxycarbide for photonics applications.
Suppression of IL-12 Production by Tristetraprolin through Blocking NF-кB Nuclear Translocation (2013)

Tristetraprolin (TTP), an mRNA-binding protein, plays a significant role in regulating the expression of adenylate-uridylate-rich elements containing mRNAs. Mice deficient of TTP (TTP(-/-)) develop a systemic autoimmune inflammatory syndrome characterized by cachexia, conjunctivitis, and dermatitis. IL-12 plays a crucial role in immune defense against infectious and malignant diseases. In this study, we found increased production of IL-12 during endotoxic shock and enhanced Th1 cells in TTP knockout mice. The levels of IL-12 p70 and p40 protein as well as p40 and p35 mRNA were also increased in activated macrophages deficient of TTP. In line with these findings, overexpression of TTP suppressed IL-12 p35 and p40 expression at the mRNA and promoter level, whereas it surprisingly had little effects on their mRNA stability. Our data showed that the inhibitory effects of TTP on p35 gene transcription were completely rescued by overexpression of NF-кB p65 and c-Rel but not by the p50 in activated macrophages. Our data further indicated that TTP acquired its inhibition on IL-12 expression through blocking nuclear translocation of NF-кB p65 and c-Rel while enhancing p50 upon stimulation. In summary, our study reveals a novel pathway through which TTP suppresses IL-12 production in macrophages, resulting in suppression of Th1 cell differentiation. This study may provide us with therapeutic targets for treatment of inflammatory and autoimmune disorders.
Pharmacologic treatments for the behavioral symptoms associated with autism spectrum disorders across the lifespan. (2012)

This review outlines pharmacologic treatments for the behavioral symptoms associated with autism spectrum disorders (ASDs) in children, adolescents, and adults. Symptom domains include repetitive and stereotyped behaviors, irritability and aggression, hyperactivity and inattention, and social impairment. Medications covered include serotonin reuptake inhibitors (SRIs), mirtazapine, antipsychotics, psychostimulants, atomoxetine, α-2 agonists, D-cycloserine, and memantine. Overall, SRIs are less efficacious and more poorly tolerated in children with ASDs than in adults. Antipsychotics are the most efficacious drugs for the treatment of irritability in ASDs, and may be useful in the treatment of other symptoms. Psychostimulants demonstrate some benefit for the treatment of hyperactivity and inattention in individuals with ASDs, but are less efficacious and associated with more adverse effects compared with individuals with ADHD. D-cycloserine and memantine appear helpful in the treatment of social impairment, although further research is needed.
Optical coherence tomography for the diagnosis of human otitis media (2013)

We report the application of Optical Coherence Tomography (OCT) to various types of human cases of otitis media (OM). Whereas conventional diagnostic modalities for OM, including standard and pneumatic otoscopy, are limited to visualizing the surface information of the tympanic membrane (TM), OCT is able to effectively reveal the depth-resolved microstructural below the TM with a very high spatial resolution. With the potential advantage of using OCT for diagnosing different types of OM, we examined in-vivo the use of 840 nm wavelength, and OCT spectral domain OCT (SDOCT) techniques, in several human cases including normal ears, and ears with adhesive and effusion types of OM. Peculiar positions were identified in two-dimensional OCT images of abnormal TMs compared to images of a normal TM. Analysis of A-scan (axial depth-scans) data from these positions could successfully identify unique patterns for different constituents within effusions. These OCT images may not only be used for constructing a database for the diagnosis and classification of OM, but they may also demonstrate the feasibility and advantages for upgrading the current otoscopy techniques.
ChemInform Abstract: Stereoselective Synthesis of α‐C‐(Alkynyl)‐glycosides via Ring‐ Opening of α‐1,2‐Anhydrosugars. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death (2014)

Hereditary pancreatitis (HP) is an autosomal dominant disease that displays the features of both acute and chronic pancreatitis. Mutations in human cationic trypsinogen (PRSS1) are associated with HP and have provided some insight into the pathogenesis of pancreatitis, but mechanisms responsible for the initiation of pancreatitis have not been elucidated and the role of apoptosis and necrosis has been much debated. However, it has been generally accepted that trypsinogen, prematurely activated within the pancreatic acinar cell, has a major role in the initiation process. Functional studies of HP have been limited by the absence of an experimental system that authentically mimics disease development. We therefore developed a novel transgenic murine model system using wild-type (WT) human PRSS1 or two HP-associated mutants (R122H and N29I) to determine whether expression of human cationic trypsinogen in murine acinar cells promotes pancreatitis. The rat elastase promoter was used to target transgene expression to pancreatic acinar cells in three transgenic strains that were generated: Tg(Ela-PRSS1)NV, Tg(Ela-PRSS1*R122H)NV and Tg(Ela-PRSS1*N29I)NV. Mice were analysed histologically, immunohistochemically and biochemically. We found that transgene expression is restricted to pancreatic acinar cells and transgenic PRSS1 proteins are targeted to the pancreatic secretory pathway. Animals from all transgenic strains developed pancreatitis characterised by acinar cell vacuolisation, inflammatory infiltrates and fibrosis. Transgenic animals also developed more severe pancreatitis upon treatment with low-dose cerulein than controls, displaying significantly higher scores for oedema, inflammation and overall histopathology. Expression of PRSS1, WT or mutant, in acinar cells increased apoptosis in pancreatic tissues and isolated acinar cells. Moreover, studies of isolated acinar cells demonstrated that transgene expression promotes apoptosis rather than necrosis. We therefore conclude that expression of WT or mutant human PRSS1 in murine acinar cells induces apoptosis and is sufficient to promote spontaneous pancreatitis, which is enhanced in response to cellular insult.
一个好“机”两个帮 (1995)

如果单处理器无法满足应用需求,也许双处理器可以胜任。随着发掘多处理器威力的桌面操作系统(如NetWare MP、OS/2 for SymmetricalMultiprocessing 和 Windows NT)的日渐增多,单处理器 PC 日显弱小。多处理器 PC 在 UNIX 领域早已大显身
Eradication ofHelicobacter pylori: therapies and clinical implications (1992)

This review presents a critical evaluation of the role of Helicobacter pylori eradication in the management of peptic ulcer disease and non-ulcer dyspepsia. On current evidence, H. pylori eradication therapy seems likely to emerge as the most rational and cost-effective treatment for duodenal ulcer. The role of H. pylori eradication in the treatment of gastric ulcer and non-ulcer dyspepsia is unclear and requires further study. The emerging problem of antibiotic resistance in H. pylori is of major clinical importance and a prime cause of treatment failure. There is increasing evidence of a link between H. pylori and gastric cancer but it is premature to recommend large-scale eradication of H. pylori as a valid strategy for the primary prevention of gastric cancer. The search continues for the ideal H. pylori eradication regimen.
Frank H. Westheimer (1912–2007) (2007)

ADVERTISEMENT RETURN TO ISSUEPREVIn FocusNEXTFrank H. Westheimer (1912–2007)E. J. Corey†* and D. E. Koshland, Jr.‡*View Author Information† Department of Chemistry and Chemical Biology, Conant Chemistry Lab, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138 ‡ Department of Molecular and Cell Biology, University of California, Berkeley, 16 Barker Hall #3202, Berkeley, California 94720-3202 * Corresponding authors, [email protected], [email protected]Cite this: ACS Chem. Biol. 2007, 2, 7, 449–450Publication Date (Web):July 20, 2007Publication History Received12 July 2007Accepted12 June 2007Published online20 July 2007Published inissue 1 July 2007https://pubs.acs.org/doi/10.1021/cb7001297https://doi.org/10.1021/cb7001297newsACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views243Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical reactions,Electrostatics,Military science,Students Get e-Alerts
Implant Drill Characteristics: Thermal and Mechanical Effects of Two-, Three-, and Four-Fluted Drills (2016)

Within the limitations of the study, a two-fluted drill would be preferred for osteotomy preparation due to its level of heat generation, whereas a three-fluted drill showed favorable cutting efficiency.
BEGINNING EXPERIMENTS WITH SEGMENTED NaI(Tl) SCINTILLATION DETECTORS. (2006)

Abstract not provided.