gebhart/patrepeval huggingface dataset:
Self-assembling, protein-based intracellular bacterial organelles: emerging vehicles for encapsulating, targeting and delivering therapeutical cargoes (2011)

Many bacterial species contain intracellular nano- and micro-compartments consisting of self-assembling proteins that form protein-only shells. These structures are built up by combinations of a reduced number of repeated elements, from 60 repeated copies of one unique structural element self-assembled in encapsulins of 24 nm to 10,000-20,000 copies of a few protein species assembled in a organelle of around 100-150 nm in cross-section. However, this apparent simplicity does not correspond to the structural and functional sophistication of some of these organelles. They package, by not yet definitely solved mechanisms, one or more enzymes involved in specific metabolic pathways, confining such reactions and sequestering or increasing the inner concentration of unstable, toxics or volatile intermediate metabolites. From a biotechnological point of view, we can use the self assembling properties of these particles for directing shell assembling and enzyme packaging, mimicking nature to design new applications in biotechnology. Upon appropriate engineering of the building blocks, they could act as a new family of self-assembled, protein-based vehicles in Nanomedicine to encapsulate, target and deliver therapeutic cargoes to specific cell types and/or tissues. This would provide a new, intriguing platform of microbial origin for drug delivery.
Visions: Artists Living with Epilepsy (2003)

Visions: Artists Living with is a magnificent volume which captures beautiful, insightful, and haunting images that reveal the souls of artists touched by epilepsy. This Deluxe Edition comes with a CD-ROM which contains all of the over 200 full-color art reproductions from the book. Each piece of art was created by artists who have epilepsy. The collection not only showcases this artwork, but also celebrates their achievement. Endorsed by the Epilepsy Foundation, this collection should serve as an inspiration to anyone affected by epilepsy. It includes the artists biographies. CD-ROM of the artwork is also available and is included with the Deluxe Edition.
High Energy Mill Processing of Polymer Based Nanocomposites (2008)

Polymer matrix nanocomposites have attracted growing attention due to the potential for significantly improving the properties of the polymer by adding a very small amount of nanoparticles. However, the improvement in properties has been related to the degree of dispersion of the nanoparticles in the polymer matrix and, due to their enormous specific surface area, nanoparticles tend to agglomerate. Thus, processing techniques able to produce complete particle dispersion in polymer matrix are of great interest. The purpose of this work is to present a new processing technique for polymer matrix nanocomposites using a high energy mill as an effective approach to disperse ceramic nanoparticles in a polymer matrix. SiO 2 /epoxy nanocomposites were processed with various SiO 2 contents using the proposed approach. Transmission electron microscopy (TEM) micrographs of the nanocomposites processed indicated good particle dispersion. In addition, agglomerates were not observed on the scanning electron microscopy (SEM) fractographs of the nanocomposites, up to 3wt% SiO 2 . The processed nanocomposites were also characterized by dynamic mechanical analysis (DMA) to investigate the effect of nanoparticles content on the viscoelastic properties and on the glass transition temperature. In summary, the technique was found promising in achieving good levels of particle dispersion in a thermoset polymer matrix.
Large-Scale IP Traffic Matrix Estimation Based on Backpropagation Neural Network (2008)

Traffic matrix estimation is significantly important for operators. However, it is difficult to estimate accurately traffic matrix. This paper proposes a novel method of large-scale IP traffic matrix estimation, termed the backpropagation neural network and iterative proportional fitting procedure (BPNNIPFP). Firstly, we model the large-scale IP traffic matrix estimation using the backpropagation neural network (BPNN) that has been studied widely. By training the BPNN, we can build the model of large-scale IP traffic matrix estimation. Secondly, combined with the model and iterative proportional fitting procedure (IPFP), the good estimations of the large-scale IP traffic matrix are attained. Finally, we use the real data from the Abilene network to validate BPNNIPFP. Simulation results show that BPNNIPFP can perform the accurate estimation of large-scale IP traffic matrix, and track well its dynamics.
COVID-19 Antibodies in Convalescent Plasma Evaluated by the C19-Kodecyte (Anti-SARS-CoV-2 Red Cell) Assay (2021)

Background/Case Studies: We had developed a simple and rapid red cell agglutination assay for serologic screening of antibodies to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We evaluated this new C19-kodecyte assay in a cohort of convalescent patients with PCR-confirmed SARS-CoV-2 infection and compared its analytical performance with three established assays. Study Design/Methods: Red cells modified with peptides from SARS-CoV-2 spike protein using the Kode Technology were prepared.We tested plasma samples from 140 convalescent plasma donors and 125 healthy donors that had tested negative for anti-SARS-CoV-2 Total (Ortho). Plasma samples were stored at -30 °C before testing. Testing was performed using the column agglutination technology commonly employed for blood typing. The results were evaluated and compared with the results of a virus neutralization assay and two commercial chemiluminescent antibody tests: Ortho anti-SARS-CoV-2 Total (IgG, IgM and IgA) assay and Ortho anti-SARS-CoV-2 IgG antibody assay. Results/Findings: The median time interval from the onset of symptoms and plasma donation was 94 days (range: 33 - 331 days). Our simple and rapid C19-kodecyte assay detected SARS-CoV-2 antibodies with a specificity of 95.2% and sensitivity of 92.1%. Correlation analysis of measurement data among the different platforms showed a weak to moderate concordance. The Pearson correlation coefficient ranged between 0.21 and 0.28 for C19-kodecyte versus Ortho anti-SARS-CoV-2 Total and Ortho anti-SARS-CoV-2 IgG assays while it was 0.24 between C19-kodecyte and neutralizing titer. Agreements among C19-kodecyte versus Ortho anti-SARS-CoV-2 Total and Ortho anti-SARS-CoV-2 IgG assays were moderate: 0.41 (0.09-0.73) and 0.41 (0.14-0.68), respectively. Conclusions: Sensitivity and specificity of the C19-kodecyte assay are within the estimated range of FDA issued EUA authorized serology tests (88% to 100% sensitivity and 95% to 100% specificity). The low correlation between C19-kodecyte versus Ortho anti-SARSCoV- 2 results and between C19-kodecyte versus neutralizing titer suggests that COVID-19 patients develop a broad antibody repertoire against multiple SARS-CoV-2 proteins and epitopes and different assays detect diverse antibody specificities. Our easily scalable approach using C19-kodecytes can be operated in blood typing laboratories worldwide using common routine setups. The availability of standard blood group serology techniques for SARS-CoV-2 antibody screening could vastly improve assay capacity. This would be particularly useful in developing countries, where dedicated virology and microbiology may be lacking the necessary turnaround capacity.
High frequency relaxation in ferroelectric ceramics containing silver and with TKWB structure (1990)

Abstract The high frequency dependence of the permittivities of a ceramic with composition Ba2AgNb5O15 gives evidence to a relaxation with a Cole-Davidson behavior. Calculations show that the values of the permittivities vs frequency are strongly modified by the porosity, but the Cole-Davidson behavior is not.
Losing Vietnam (2013)

This book chronicles the efforts of U.S. military and State Department officials after the official ceasefire in Vietnam who argued that severe congressional budget reductions would lead to the ultimate defeat of both Cambodia and South Vietnam. It details the catastrophic effects of reduced funding and of conducting “wars by budget.” These reductions portended the ultimate defeats of both South Vietnam and Cambodia and although the warning signs of potential collapses were definitely evident and reported by USSAG, they were generally ignored by superior headquarters. It highlights how analytical studies provided to commanders and staff agencies improved decision making in military operations. By assessing allied capabilities and the strength of enemy operations, this book argues that America’s lack of financial support and resolve doomed both countries to defeat.
Intrinsic expression of host genes and intronic miRNAs in prostate carcinoma cells (2009)

Our results suggest that miRNA expression profiles may not predict intrinsic hormone-sensitive environment of PCa cells. More importantly, our data indicate the possibility of additional novel mechanisms for intronic miRNA processing in PCa cells.
Constrained (closed-loop) robot simulation by local constraint propagation (1986)

Robot mechanisms during many typical interactions with their environment have long posed a difficulty to computer simulation. This is due to the coupling of effects from the base and the tip (the closed loop problem), often complicated by mixtures of known and unknown endpoint forces and accelerations. This paper presents a linear-time (recursive) algorithm for the closed-loop forward dynamics of kinematic chains under very general environmental endpoint constraints. The statement of very complex systems of endpoint constraints is particularly easy, and the algorithm is conceptually simple and physically intuitive. The algorithm is then generalized to branching kinematic chains (trees), where every endpoint may be subject to environmental (closed-loop) constraints. The time complexity for constrained kinematic trees remains also linear in the number of joints. An appendix sketches an extension of the algorithm to general kinematic structures with one-dof joints, but containing arbitrary internal closed loops. The time complexity with internal loops is no worse than O(n) + O(l <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , for n joints and l internal loops; for many structures the algorithm attains O(n)+ O[l\log(l)].
Design and performance evaluation of protected Super-EPON Access networks using a dedicated protection ring architecture (2007)

This paper describes and tests the feasibility of a protected super Ethernet passive optical network (Super-EPON). The architecture of the Super-EPON is based on a two-fiber ring that provides protection to the feeder section of the supported EPONs. The performance evaluation of the network is measured by simulating the behavior of dynamic bandwidth allocation (DBA) algorithms with quality of service (QoS) support in the upstream traffic management. The results are examined in terms of mean packet delay, mean bit rate per optical network unit (ONU), time-slot occupation efficiency, data packet loss, and overhead due to Ethernet headers and multi-point control protocol (MPCP) messages.
Preface: Phys. Status Solidi A 206/2 (2009)

Abstract The Seventh International Symposium on Semiconductor Light Emitting Devices (ISSLED 2008) was held in Phoenix, Arizona, on the week of 27 April to 2 May 2008. This Symposium is a new edition of the International Symposium on Blue Laser and Light Emitting Diodes (ISBLLED) series which has been held biannually to provide a platform for scientists and engineers to discuss progress and future trends in the rapidly advancing wide band gap semiconductor science and technologies and their applications into visible and ultraviolet light emitting diodes and diode lasers. The first symposium in the series was organized by Prof. Akihiko Yoshikawa and was held in Chiba, Japan, in 1996. The following symposia were held in Chiba, Japan, in 1998; Berlin, Germany, in 2000; Cordoba, Spain, in 2002; Geongju, Korea, in 2004; and more recently in Montpellier, France, in 2006. The participants were 33 from Asia (16 from Japan), 19 from Europe, and 66 from North America. The ISSLED 2008 scientific program included a total of 14 invited talks and 63 contributed talks. This symposium covered materials and their devices based on GaN, ZnSe, and ZnO semiconductors. The topics included materials growth and characterization, optoelectronic properties, device design and fabrication, white light emitting diodes, ultraviolet emitters and detectors, photonics, device performance and reliability, novel optoelectronic devices and applications, spintronics, and biological applications. The next meeting in this series was proposed, and accepted by the International Advisory Committee, to be held in China, in May 2010, to be organized by Prof. Guoyi Zhang of Peking University (© 2009 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Novel tankyrase-related gene detected with meningioma-specific sera. (2001)

In many meningiomas, alterations of chromosome 22 can be found, and the NF2 (neurofibromatosis type 2) gene, in particular, is of great interest as a putative gene involved in meningioma. Because the NF2 gene is not mutated in all meningiomas, additional genes may be involved. Instead of looking for alterations directly at the DNA level, we used the immune response of meningioma patients to identify immunogenic antigens that may be associated with the disease. We screened a fetal brain cDNA expression library with sera pools from different patients bearing meningioma classified according to the three WHO grades, using the serological identification of antigens by recombinant expression cloning immunological screening method. Here, we report the finding of a new tankyrase-related protein. We found 16 overlapping clones with homologies to tankyrase when we screened the library with the common-type meningioma sera pool and 2 such clones when we screened the library with the atypical meningioma sera. The anaplastic meningioma sera did not identify any tankyrase-related clones. We tested some of the newly identified clones with 13 single sera, 6 of which (37.5%) reacted positively with the tankyrase-related clones. In addition, we screened the tankyrase-related clone with six sera pools from individuals without obvious disease. Although 1 of 24 (4.2%) normal sera reacted with the tankyrase-related clone, we found a striking difference in the frequency of reactivity to this clone by sera from patients bearing tumors corresponding to the three WHO meningioma grades; common-type sera was the most frequently reactive. Northern blot analysis demonstrates expression of the novel tankyrase gene in two common-type meningiomas from patients with immune response.
Intrathecal Acetyl Cholinesterase Inhibitors Produce Analgesia That Is Synergistic with Morphine and Clonidine in Rats (1995)

Intrathecal (IT) administration of acetyl cholinesterase inhibitors produces analgesia through a muscarinic action.The addition of IT cholinergic agonists to IT opioids or alpha2-adrenergic agonists results in enhanced analgesic effects, but it is not clear whether these interactions are synergistic, additive, or less than additive. Dose-response curves for hot plate and tail immersion tests were established for IT neostigmine, physostigmine, and echothiophate in rats. Dose-response curves for hot plate testing were established for IT morphine and clonidine. The effect of maximally effective doses of each of the three cholinergic drugs on hot plate testing was plotted over time. Isobolographic analysis was performed for hot plate testing using neostigmine-morphine and neostigmine-clonidine combinations. The three cholinesterase inhibitors produced profound analgesia on hot plate testing but incomplete analgesia using the tail immersion test. Duration of analgesia on hot plate testing ranged from 45 min for physostigmine to more than 24 h for echothiophate. IT administration of combinations of neostigmine plus morphine and neostigmine plus clonidine both produced significantly more profound analgesia than the calculated additive effects and are, therefore, synergistic in their actions. (Anesth Analg 1995;81:501-7)
The selective reduction of .alpha.,.beta.-unsaturated esters, nitriles and nitro compounds with sodium cyanoborohydride (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe selective reduction of .alpha.,.beta.-unsaturated esters, nitriles and nitro compounds with sodium cyanoborohydrideRobert O. Hutchins, David Rotstein, Nicholas Natale, Joseph Fanelli, and Donald DimmelCite this: J. Org. Chem. 1976, 41, 20, 3328–3329Publication Date (Print):October 1, 1976Publication History Published online1 May 2002Published inissue 1 October 1976https://pubs.acs.org/doi/10.1021/jo00882a029https://doi.org/10.1021/jo00882a029research-articleACS PublicationsRequest reuse permissionsArticle Views1649Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nodal root diameter and node number in maize ( Zea mays L. ) interact to influence plant growth under nitrogen stress (2020)

Abstract Under nitrogen limitation, plants increase resource allocation to root growth relative to shoot growth. The utility of various root architectural and anatomical phenotypes for nitrogen acquisition are not well understood. Nodal root number and root cross-sectional area were evaluated in maize in field and greenhouse environments. Nodal root number and root cross-sectional area were inversely correlated under both high and low nitrogen conditions. Attenuated emergence of root nodes, as opposed to differences in the number of axial roots per node, was associated with substantially reduced root number. Greater root cross-sectional area was associated with a greater stele area and number of cortical cell files. Genotypes that produced few, thick nodal roots rather than many, thin nodal roots had deeper rooting and better shoot growth in low nitrogen environments. Fewer nodal roots offset the respiratory and nitrogen costs of thicker diameter roots, since total nodal root respiration and nitrogen content was similar for genotypes with many, thin and few, thick nodal roots. We propose that few, thick nodal roots may enable greater capture of deep soil nitrogen and improve plant performance under nitrogen stress. The interaction between an architectural and anatomical trait may be an important strategy for nitrogen acquisition. Understanding trait interactions among different root nodes has important implications in for improving crop nutrient uptake and stress tolerance.
The relationship between obsessive-compulsive disorder and religious faith: Clinical characteristics and implications for treatment. (2013)

This paper explores the relationship between religion and obsessive– compulsive disorder (OCD), with particular interest in religion’s possible influence in the development of OCD and its impact on treatment outcome. The paper begins with a review of theoretical and research literatures concerning religious involvement, research evidence linking religious involvement and physical and mental health, and theoretical linkages supporting both positive and negative religious effects on health. Following this, we provide a general overview and description of OCD and information concerning the prevalence and incidence of religiously based OCD. Next, extant research linking religion and OCD is presented. Information relevant to the clinical treatment of OCD with religious content is discussed. Finally, practice implications for clinicians and clergy are provided.
Three-dimensional Optical Transfer Function for Weak Aberrations (1995)

Abstract The phase variations of the three-dimensional optical transfer function for incoherent optical systems with weak aberrations of different types are developed in algebraic form. Both single Seidel terms and Zernike sums are considered.
Bioremediation Technology Development and Application to the Alaskan Spill (1991)

ABSTRACT Bioremediation was used to clean oil-contaminated shorelines in Prince William Sound following the Exxon Valdez oil spill. Among the approaches considered for enhancing natural rates of oil biodegradation, nutrient applications became the principal focus. Bioremediation studies were conducted in a cooperative effort of Exxon, the U.S. Environmental Protection Agency, and scientists in academia. Field testing of nutriation of indigenous oil-eating microorganisms was conducted early in the summer of 1989, and full-scale application followed. Monitoring during the fall and winter of 1989–90 revealed the evident benefit of the technique and supported additional applications in 1990. The efficacy of bioremediation was demonstrated by measurement of numbers of hydrocarbon-degrading microorganisms, microbial hydrocarbon-degrading activities, and chemical changes in residual oil. This paper discusses laboratory and field programs demonstrating the efficacy and environmental safety of bioremediation, and reviews the materials and methods chosen for large-scale application.
Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway (2009)

Acyclic retinoid (ACR) is currently under clinical trial as an agent to suppress the recurrence of hepatocellular carcinoma (HCC) through its ability to induce apoptosis in premature HCC cells. ACR has an anticancer effect in vivo as well, although it shows weak apoptosis-inducing activity against mature HCC cells, suggesting the existence of an additional action mechanism. In this study, we investigated the antiangiogenic activity of ACR. ACR inhibited angiogenesis within chicken chorioallantoic membrane (CAM) in as similar a manner as all-trans retinoic acid (atRA). Although suppression of angiogenesis by atRA was partially rescued by the simultaneous addition of angiopoietin-1, suppression of angiogenesis by ACR was not rescued under the same condition at all. Conversely, although suppression of angiogenesis by ACR was partially inverted by the simultaneous addition of vascular endothelial growth factor (VEGF), suppression of angiogenesis by atRA was not affected under the same condition. These results suggested that mechanisms underlying the suppression of angiogenesis by ACR and atRA were different. ACR selectively inhibited the phosphorylation of VEGF receptor 2 (VEGFR2) and of extracellular signal-regulated kinase (ERK) without changing their protein expression levels, and inhibited endothelial cell growth, migration, and tube formation. The inhibition of the phosphorylation of ERK, endothelial growth, migration, tube formation, and angiogenesis by ACR was rescued by the overexpression of constitutively active mitogen-activated protein kinase (MAPK). Finally, ACR, but not atRA, inhibited HCC-induced angiogenesis in a xenografted CAM model. These results delineate the novel activity of ACR as an antiangiogenic through a strong inhibition of the VEGFR2 MAPK pathway.