gebhart/patrepeval huggingface dataset:
Determination of Plasma Concentrations of Propofol Associated with 50% Reduction in Postoperative Nausea (1997)

Propofol is generally efficacious in treating postoperative nausea and vomiting at plasma concentrations that do not produce increased sedation. Simulations indicate that to achieve antiemetic plasma propofol concentrations of 343 ng/ml, a bolus dose of 10 mg followed by an infusion of approximately 10 microg x kg(-1) x min(-1) are necessary.
LTE for UMTS - OFDMA and SC-FDMA Based Radio Access (2009)

From the editors of the highly successful WCDMA for UMTS, this new book gives a complete and up-to-date overview of Long Term Evolution (LTE) in a systematic and clear manner. It starts with an in-depth explanation of the background and standardization process before moving on to examine the system architecture evolution (SAE). The basics of air interface modulation choices are introduced and key subjects such as 3GPP LTE physical layer and protocol solutions are described. Mobility aspects and radio resource management together with radio and end-to-end performance are assessed. The voice solution and voice capacity in LTE are also illustrated. Finally, the main differences between LTE TDD and FDD modes are examined and HSPA evolution in 3GPP Releases 7 and 8 is described. LTE for UMTS is one of the first books to provide a comprehensive guide to the standards and technologies of LTE. Key features of the book include: Covers all the key aspects of LTE in a systematic manner Presents full description of 3GPP Release 8 LTE Examines the expected performance of LTE Written by experts actively involved in the 3GPP standards and product development.
Short-term Training is Accompanied by a Down Regulation of ACC2 mRNA in Skeletal Muscle (2006)

Recently, we showed that short-term training induced a rapid increase in IMCL whilst insulin sensitivity tended to improve. Here we investigate molecular adaptations accompanying this physiological training-induced accumulation of IMCL. Nine untrained men (age: 23.3 +/- 3.2 y; maximal power output: 3.8 +/- 0.6 W/kg body weight) trained for two weeks. Before and after training, subjects cycled for three hours and biopsies were taken before and after exercise. mRNA concentrations of ACC2, HSL, LPL, Glut4 and HKII were quantified by RT-PCR and association of Glut4 with the membrane was quantified by immunohistochemical method. Endurance training resulted in a decrease of 29.1 % in ACC2 mRNA (p = 0.02). After training, ACC2 mRNA tended to decrease with acute exercise (- 24.4 % [p = 0.06]). HSL mRNA decreased with acute exercise after training (- 37.3 % [p = 0.002]). LPL mRNA concentrations increased with acute exercise before training (+ 42.4 % [p = 0.05]) and HKII mRNA increased with acute exercise before (+ 72.5 % [p = 0.025]) and after training (+ 99.3 % [p = 0.05]). After acute exercise, more Glut4 was associated with the membrane than before exercise, but it was not affected by training. We conclude that the training-induced increase in IMCL was accompanied by molecular adaptations in muscle to improve fat oxidative capacity, while markers of glucose metabolism were not yet changed. The present data are in line with the hypothesis that the fat oxidative capacity might be more important than the IMCL content in determining insulin sensitivity.
Mehrcyclische Azine mit Heteroatomen in 1‐ und 3‐Stellung, 22. Mitt. Eine einfache Synthese von 2‐Alkylthio‐4‐amino‐thieno[2,3‐d]pyrimidinen (1989)

Abstract Die Reaktion von 2‐Benzoylthioureido‐thiophen‐3‐carbonitrilen D/ 8 , 9 it verd. NaOH liefert die 4‐Amino‐thieno[2,3‐d]pyrimidin‐2 (1H)‐thione E/ 10 , 11. Die Verbindungen D reagieren in alkalischer Lösung mit verschiedenen Alkylhalogeniden in einer Synthesestufe zu den 2‐Alkylthio‐4‐amino‐thieno[2, 3‐d]pyrimidinen F/ 12‐18 in guten Ausbeuten. Die Hydrolyse von F führt zu den 4‐Amino‐thieno[2, 3‐d]pyrimidin‐2 (1H)‐onen G/ 19 , 20 . Die ms Fragmentierung von E/ 10 , 11 und G/ 19 , 20 wird diskutiert.
Crystal structure of a dimeric oxidized form of human peroxiredoxin 5. (2003)

peer reviewed
ERRATUM: Recommendations for the Use of Next-Generation Sequencing and the Molecular Tumor Board for Patients with Advanced Cancer: A Report from KSMO and KCSG Precision Medicine Networking Group (2023)

For the data represented in Table 2, we have corrected the level of evidence of K-CAT level 2 and 3.As the table shown, prospective phase I/II trials required for K-CAT level 2 include clinical trials across tumor types, such as basket trials.For the clinical benefit of specific cancer types, expert consensus is needed.K-CAT level 3A requires a retrospective study or case series with potential clinical benefit in s specific tumor types.K-CAT level 3B is revised from a retrospective study as clinical studies show potential clinical benefits in other indications.The corrected version of the table is below.
Virus Evolution (2001)

Abstract Viruses act as independent evolutionary units in continuous interaction with their host organisms. The evolutionary strategies of DNA and RNA viruses differ.
Field Translocation of Mountain Pine Beetles Suggests Phoretic Mite Communities Are Locally Adapted, and Mite Populations Respond Variably to Climate Warming (2021)

Temperature is a key determining factor in the population dynamics of forest insects and their associated biota. Bark beetles, often considered key agents of change in forest ecosystems, are particularly affected by warming in their environment. Beetles associate with various phoretic mite species that have direct/indirect effects on beetle fitness and population dynamics, although there is limited knowledge of how temperature affects these communities. Here, we use a field reciprocal translocation experiment with the addition of a novel "warming" environment to represent future changes in local environment in two populations of a keystone bark beetle species (<i>Dendroctonus ponderosae</i>). We hypothesize that mite community abundances as carried by bark beetles are significantly altered when not in their native environments and when subjected to climate warming. We use multivariate generalized linear models based on species abundance data to show that mite community compositions significantly differ across different field climates; and that these patterns diverge between source populations, indicating local adaptation. Our study offers foundational information on the general effects of simulated climate-warming on the compositional shifts of common and abundant biotic associates of mountain pine beetles and may be used as a model system for other important insect-mite systems.
Discovery of benzothiazole-based thiazolidinones as potential anti-inflammatory agents: anti-inflammatory activity, soybean lipoxygenase inhibition effect and molecular docking studies (2022)

Despite the greatest achievement in the development of anti-inflammatory agents in the last two decades, the current clinical drugs suffer from a variety of complications in community settings and hospital. There is still an urgent need to design novel molecules with better safety profile and with different molecular targets from those in current clinical use. The aim of this research was to discover a series of benzothiazole-based thiazolidinones with lipoxygenase (LOX) inhibitory activity as a mechanism of anti-inflammatory action. Carrageenan-induced mouse foot paw oedema assay was carried out to determine the anti-inflammatory activity, while LOX inhibition was examined through the conversion of sodium linoleate to 13-hydroperoxylinoleic acid. Molecular docking studies were performed using AutoDock 4.2 software. The anti-inflammatory activity of the title compounds was determined in a range of 18.4%-69.57%, where compound #3 was found to be the most potent (69.57%) and also to be more active than the reference drug indomethacin (47%). Moreover, compound #3 showed the highest LOX inhibitory activity with IC<sub>50</sub> of 13 μM being less potent to that of the reference NDGA (IC<sub>50</sub> = 1.3 μM). Compound #3 has been identified as lead compound for further modification in an attempt to improve anti-inflammatory and LOX inhibitory activities.
Principles of an atomtronic battery (2013)

An asymmetric atom trap is investigated as a means to implement a ``battery'' that supplies ultracold atoms to an atomtronic circuit. The battery model is derived from a scheme for continuous loading of a nondissipative atom trap proposed by Roos et al. [C. F. Roos, P. Cren, D. Guery-Odelin, and J. Dalibard, Europhys. Lett. 61, 187 (2003)]. The trap is defined by longitudinal and transverse trap frequencies ${f}_{z}$ and ${f}_{\ensuremath{\perp}}$ and corresponding trap energy heights ${U}_{z}$ and ${U}_{\ensuremath{\perp}}$. The battery's ability to supply power to a load is evaluated as a function of an input atom flux and power, ${I}_{\mathrm{in}}$ and ${P}_{\mathrm{in}}={I}_{\mathrm{in}}(1+\ensuremath{\epsilon}){U}_{z}$, respectively, where $\ensuremath{\epsilon}$ is an excess fractional energy. For given trap parameters, the battery is shown to have a resonantly optimum value of $\ensuremath{\epsilon}$. The battery behavior can be cast in terms of an equivalent circuit model; specifically, for fixed input flux and power the battery is modeled in terms of a Th\'evenin equivalent chemical potential and internal resistance. The internal resistance establishes the maximum power that can be supplied to a circuit, the heat that will be generated by the battery, and the noise that will be imposed on the circuit. We argue that any means of implementing a battery for atomtronics can be represented by a Th\'evenin equivalent and that its performance will likewise be determined by an internal resistance.
Laboratory Study of Injection Strategy for Low-Tension-Gas Flooding in High Salinity, Tight Carbonate Reservoirs (2018)

Abstract It has been experimentally observed that Low-Tension-Gas (LTG) flooding can be a suitable enhanced oil recovery (EOR) method for low-permeability carbonate reservoirs with high salinity and hard formation brine. LTG flooding improves oil recovery by combining two effects: a reduction of the interfacial tension (IFT) between oil and water and mobility control through the formation of in-situ foam with an injected gas. However, the high cost of chemicals and/or the limited supply of gas can make this process economically challenging. In order to optimize the LTG process, an injection strategy has been designed such that the oil recovery can be maximized, using a minimum amount of the injected gas and the surfactant, thereby ensuring a more economically-viable recovery process. A low-permeable (&amp;lt;10 md) Middle Eastern limestone reservoir with a high formation brine salinity (~200,000 ppm and hardness 19,000 ppm) is the target reservoir of this study. Surfactant injection strategy was optimized by varying the concentration and pore volumes of the surfactant slug injected. Nitrogen gas was co-injected during select time periods throughout the entire chemical injection in order to identify the significance of mobility control during the crucial phases of the LTG flooding. The coreflood results emphasized the significance of the injection of gas, even at lower foam quality, for the maintenance of mobility control. Ultimate oil recovery of over 60% (residual oil post waterflood) was achieved, even after reducing the surfactant concentration by 75% and inducing a different in-situ salinity profile as compared to earlier studies. An innovative method for measuring surfactant adsorption using Liquid Chromatography and Mass Spectrometry (LC-MS) was developed, which could provide individual dynamic adsorption data for each of the three classes of surfactants used.
Suppression of IgE-mediated disease by rapid desensitization with anti-FcεRIα mAb (HYP3P.345) (2014)

Abstract IgE-mediated mast cell and basophils activation is critical for the pathogenesis of anaphylaxis, drug allergy, food allergy and allergic skin disorders and contributes to the pathogenesis of asthma and allergic rhinitis. We recently demonstrated that IgE-mediated anaphylaxis in mice can be safely blocked by rapid desensitization with ascending doses of an anti-mouse FcεR1α Abs, starting with a dose too small to induce detectable disease and ending with a dose that induces anaphylaxis if injected into previously untreated mice (JACI, 131:1555-64, 2013). We have now modified this approach, which removes IgE from mast cells, to make it human-applicable, faster and safer. To do this, we: (1) generated a chimeric anti-human FcεR1α mAb that has V regions from a mouse anti-human FcεR1α mAb (15.1) and C regions from human IgG1; (2) substituted a mAb that binds FcεR1 regardless of whether it is associated with IgE for a mAb that only binds FcεR1 that is not IgE-associated; and (3) mutated the γ1 chain C region to increase its affinity for the inhibitory receptor, FcγRIIB. The potential usefulness of this approach has been demonstrated in IgE-mediated anaphylaxis models in mice that express human, instead of mouse FcεRIα and in human cord blood-reconstituted NSGS mice, which generate human mast cells, basophils and IgE-secreting B cells. These observations suggest that full development of this approach should provide a way to safely and rapidly suppress IgE-mediated human allergy.
Cyclic distributed garbage collection without global synchronization (1998)

In this report we show an algorithm for cyclic distributed garbage collection that does not require global coordination and is tolerant to message, network, and process failures. Most of the cyclic distributed garbage collectors use mark-and-sweep to find the transitive closure of objects that are reached from the global roots. The main disadvantage of mark-and-sweep is that it requires global coordination to know when the mark-phase has ended. Our algorithm takes a more radical approach and uses back-tracing instead of mark-and-sweep to eliminate the need for global synchronization. Starting from an object that is suspected to be garbage, the algorithm recursively traces back the references that point to the suspect to find the transitive closure of objects that reach the suspect. If this closure does not contain any root, then the objects in the closure are collected. Local garbage collectors have to be modified to provide back-references for local proxies (representation of remote o...
Stereoselective Anionic Polymerization of Amino-Substituted Masked Disilenes (2005)

Stereoselective anionic polymerization of the amino-substituted masked disilene 1, 2-dibutylamino-2,3,3-trimethyl-1-phenyl-2,3-disilabicyclo[2.2.2]octa-5,7-diene, is reported. When the polymerization of 1 was initiated with silyl anions or butyllithium, it produced a highly ordered alternating polymer structure with a diad distribution where the ratio of m/r varies from ∼1:3 to 1:9 depending on the metal ion in the anionic initiator and the polymerization temperature.
PHARMACOLOGICAL STUDIES ON FATIGUE I (1972)

Considerable investigation has been done as to whether or not a particular drug is effective for recovery of an animal after it has become exhausted. Experiments have included screening antifatigue effect on animals, but applications have not been generally established. Effects of drugs on psychological fatigue as seen in man can hardly be inferred from tests on animals. Even physiological effects of some stimulants differ, depending on the cause of exhaustion (1). There is reason to believe that enforced exercise involves stress not present in spontaneous exercise (2). As psychological and physiological factors as yet remain obscure, fatigue itself is hard to define. The present paper reports attempts to determine simple pharmacological methods for screening effects of drugs on exhausted states of animals.
Vigilancia de la salud, derecho a la intimidad y Covid-19 (2020)

En este trabajo se plantea, a la luz de la situación que estamos viviendo con la pandemia declarada por la OMS el pasado 11 de marzo de 2020, ocasionada por el COVID-19, una serie de aspectos relacionados con la vigilancia de la salud y el derecho a la intimidad de la persona trabajadora. Concretamente, se trata de ver cuál es la capacidad de las empresas para obligar a las personas trabajadoras a someterse a un reconocimiento médico con el fin de determinar su estado de salud en relación con el COVID-19, o la posibilidad de que las empresas lleven a cabo prácticas consistentes en realizar un reconocimiento médico con carácter previo a la contratación, o solicitar a las personas candidatas a un puesto de trabajo información sobre si han pasado el COVID-19.
Variations in Potassium Channel Genes Are Associated With Breast Pain in Women Prior to Breast Cancer Surgery (2014)

Preoperative breast pain in women with breast cancer may result from a number of causes. Previous work from our team found that breast pain occurred in 28.2% of women (n = 398) who were about to undergo breast cancer surgery. The occurrence of preoperative breast pain was associated with a number of demographic and clinical characteristics, as well as variation in two cytokine genes. Given that ion channels regulate excitability of sensory neurons, we hypothesized that variations in potassium channel genes would be associated with preoperative breast pain in these patients. Therefore, in this study, we evaluated for associations between single-nucleotide polymorphisms and inferred haplotypes among 10 potassium channel genes and the occurrence of preoperative breast pain in patients scheduled to undergo breast cancer surgery. Multivariable logistic regression analyses were used to identify those genetic variations that were associated with the occurrence of preoperative breast pain while controlling for age and genomic estimates of and self-reported race/ethnicity. Variations in four potassium channel genes: (1) potassium voltage-gated channel, delayed rectifier, subfamily S, member 1 (KCNS1); (2) potassium inwardly rectifying channel, subfamily J, member 3 (KCNJ3); (3) KCNJ6; and (4) potassium channel, subfamily K, member 9 (KCNK9) were associated with the occurrence of breast pain. Findings from this study warrant replication in an independent sample of women who report breast pain following one or more breast biopsies.
Molecular-Dynamics Analysis of the Structural Properties of Silica during Cooling (2008)

The structural properties of SiO2 liquid during cooling have been investigated by molecular dynamics simulations. The interatomic forces acting on the particles are calculated by the modified Tersoff potential parameters. The glass transition temperature and structural properties of the resulting SiO2 system at various temperatures have been investigated. The fivefold coordinations of Si and threefold coordinations of O atoms were observed, and the coordination defects of system decrease with decreasing temperature up to 17 % at 300 K. The self-diffusion coefficients for Si and O atoms drop to almost zero below 3000 K. The structures were distorted at high temperatures, but very stable atomic network persisted up to high temperature in the liquid state.
Multifunctional liquid crystal elastomers: Large electromechanical and electro-optical effects (2008)

A multifunctional main chain liquid crystal elastomer (MCLCE) with large mechanical and optical effects in applied electric fields is investigated, when MCLCE is swollen in a low molecular weight liquid crystal, 4-n-pentyl-4-cyanobiphenyl, a nematic solvent. The size change by the field effects is linearly proportional to the transmittancy change. This suggests the possibility of broad application as a field-induced-optical actuator device.
A Novel Viewpoint on the Anticipatory Postural Adjustments During Gait Initiation (2021)

Anticipatory postural adjustments (APAs) are the coordinated muscular activities that precede the voluntary movements to counteract the associated postural perturbations. Many studies about gait initiation call APAs those activities that precede the heel-off of the leading foot, thus taking heel-off as the onset of voluntary movement. In particular, leg muscles drive the center of pressure (CoP) both laterally, to shift the body weight over the trailing foot and backward, to create a disequilibrium torque pushing forward the center of mass (CoM). However, since subjects want to propel their body rather than lift their foot, the onset of gait should be the CoM displacement, which starts with the backward CoP shift. If so, the leg muscles driving such a shift are the prime movers. Moreover, since the disequilibrium torque is mechanically equivalent to a forward force acting at the pelvis level, APAs should be required to link the body segments to the pelvis: distributing such concentrated force throughout the body would make all segments move homogeneously. In the aim of testing this hypothesis, we analyzed gait initiation in 15 right-footed healthy subjects, searching for activities in trunk muscles that precede the onset of the backward CoP shift. Subjects stood on a force plate for about 10 s and then started walking at their natural speed. A minimum of 10 trials were collected. A force plate measured the CoP position while wireless probes recorded the electromyographic activities. Recordings ascertained that at gait onset APAs develop in trunk muscles. On the right side, Rectus Abdominis and Obliquus Abdominis were activated in 11 and 13 subjects, respectively, starting on average 33 and 54 ms before the CoP shift; Erector Spinae (ES) at L2 and T3 levels was instead inhibited (9 and 7 subjects, 104 and 120 ms). On the contralateral side, the same muscles showed excitatory APAs (abdominals in 11 and 12 subjects, 27 and 82 ms; ES in 10 and 7 subjects, 75 and 32 ms). The results of this study provide a novel framework for distinguishing postural from voluntary actions, which may be relevant for the diagnosis and rehabilitation of gait disorders.
Intranasal flumazenil and naloxone to reverse over‐sedation in a child undergoing dental restorations (2009)

We describe a 3-year-old child who became over-sedated after receiving intranasal (IN) midazolam (0.53 mg.kg(-1)) and IN sufentanil (1 mcg.kg(-1)) for dental restorations in the dental office. Desaturation was attributed to laryngospasm, which was managed with positive pressure ventilation and oxygen. The sedation was reversed with a combination of IN flumazenil and naloxone.