gebhart/patrepeval huggingface dataset:
Polymorphism of the GRTH/DDX25 gene in normal and infertile Japanese men: a missense mutation associated with loss of GRTH phosphorylation (2007)

The gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is present in Leydig and germ cells of rodents, and is essential for fertility in mice. This study evaluated the incidence of GRTH/DDX25 gene mutations in a group of infertile patients with non-obstructive azoospermia (NOA), 85% with a preponderance of Sertoli cells in the seminiferous tubule and 15% with spermatogenic arrest, and compared them to a group of fertile subjects. Exonic sequences in the GRTH gene were screened using denaturing high-performance liquid chromatography of the genomic DNA from 143 NOA and 100 fertile Japanese men. A unique heterozygous missense mutation Arg(242)His in exon 8 was identified in 5.8% of Sertoli cell-only patients and in 1% of normal subjects. Although the mutant protein was efficiently expressed in COS-1 cells, only the 56 kDa nuclear/cytoplasmic non-phosphorylated species was present, whereas the 61 kDa cytosolic phosporylated species was absent. In addition, a silent mutation was identified in exon 11 in NOA subjects. The Arg(242)His missense mutation of the GRTH/DDX25 gene associated with expression of a protein with reduced basicity, and the absence of the phospho-GRTH species, could be of relevance to some of the functional aspects of the protein that impact on germ cell development and/or function.
Creation of an Atrial Septal Defect Without Thoracotomy (1966)

Transposition of the great vessels (TGV) occurs in approximately 20% of children who die with congenital heart disease.<sup>1</sup>With rare exceptions, patients with this lesion die in the first 6 months of life (50% within the first month). Approximately 40% of patients with TGV have an otherwise normal heart. In recent years, various types of complete corrections for this lesion have been attempted. Mustard et al<sup>2</sup>has simplified these procedures and has reduced mortality to reasonable levels. Best results are obtained in children well beyond 6 months of age. Therefore, it is imperative to provide early palliation that is effective until the optimal age for complete correction and that does not interfere significantly with subsequent surgery. Creation of an interatrial communication seems the best available choice to suit these requirements. The Blalock-Hanlon technique,<sup>3</sup>or some modified version, is commonly used to remove a portion of the atrial
Cloning of a restriction-modification system from Proteus vulgaris and its use in analyzing a methylase-sensitive phenotype in Escherichia coli (1985)

A 4.84-kilobase-pair plasmid was isolated from Proteus vulgaris (ATCC 13315) and cloned into the plasmid vector pBR322. Plasmid pBR322 contains substrate sites for the restriction endonucleases PvuI and PvuII. The recombinant plasmids were resistant to in vitro cleavage by PvuII but not PvuI endonuclease and were found to cause production of PvuII endonuclease or methylase activity or both in Escherichia coli HB101. The approximate endonuclease and methylase gene boundaries were determined through subcloning, Bal 31 resection, insertional inactivation, DNA-dependent translation, and partial DNA sequencing. The two genes are adjacent and appear to be divergently transcribed. Most E. coli strains tested were poorly transformed by the recombinant plasmids, and this was shown by subcloning and insertional inactivation to be due to the PvuII methylase gene. At a low frequency, stable methylase-producing transformants of a methylase-sensitive strain were obtained, and efficiently transformed cell mutants were isolated from them.
Molecular structural effects involved in the interaction of quinolinemethanolamines with DNA. Implications for antimalarial action (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular structural effects involved in the interaction of quinolinemethanolamines with DNA. Implications for antimalarial actionMichael W. Davidson, Billy G. Griggs, David W. Boykin, and W. David WilsonCite this: J. Med. Chem. 1977, 20, 9, 1117–1122Publication Date (Print):September 1, 1977Publication History Published online1 May 2002Published inissue 1 September 1977https://pubs.acs.org/doi/10.1021/jm00219a002https://doi.org/10.1021/jm00219a002research-articleACS PublicationsRequest reuse permissionsArticle Views173Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Rate-programming of nano-particulate delivery systems for smart bioactive scaffolds in tissue engineering (2014)

Development of smart bioactive scaffolds is of importance in tissue engineering, where cell proliferation, differentiation and migration within scaffolds can be regulated by the interactions between cells and scaffold through the use of growth factors (GFs) and extra cellular matrix peptides. One challenge in this area is to spatiotemporally control the dose, sequence and profile of release of GFs so as to regulate cellular fates during tissue regeneration. This challenge would be addressed by rate-programming of nano-particulate delivery systems, where the release of GFs via polymeric nanoparticles is controlled by means of the methods of, such as externally-controlled and physicochemically/architecturally-modulated so as to mimic the profile of physiological GFs. Identifying and understanding such factors as the desired release profiles, mechanisms of release, physicochemical characteristics of polymeric nanoparticles, and externally-triggering stimuli are essential for designing and optimizing such delivery systems. This review surveys the recent studies on the desired release profiles of GFs in various tissue engineering applications, elucidates the major release mechanisms and critical factors affecting release profiles, and overviews the role played by the mathematical models for optimizing nano-particulate delivery systems. Potentials of stimuli responsive nanoparticles for spatiotemporal control of GF release are also presented, along with the recent advances in strategies for spatiotemporal control of GF delivery within tissue engineered scaffolds. The recommendation for the future studies to overcome challenges for developing sophisticated particulate delivery systems in tissue engineering is discussed prior to the presentation of conclusions drawn from this paper.
Supplementary Table 4 from Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening (2023)

Supplementary Table 4 from Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening
Sulfate Requirement for the Growth of U(VI)-Reducing Bacteria in an Ethanol-Fed Enrichment (2007)

ABSTRACT A field experiment at the Oak Ridge Field Research Center has demonstrated the in situ biostimulation of U(VI) reduction with ethanol amendment, but little is known about the stimulated metabolic pathways or composition of the bacterial community mediating the reduction. This work characterized the metabolism and community structure of a sulfate-reducing enrichment developed from sediment from the field site to help address this knowledge gap. Structure was investigated by clone library construction and terminal restriction fragment length polymorphism (T-RFLP) analysis of 16S rDNA. The enrichment used ethanol concomitantly with sulfate, producing acetate. Hydrogen accumulated intermittently. The clone library contained sequences related to Clostridia, Desulfovibrio, Bacteroides, and Synergistes species. The enrichment reduced U(VI), and the reduction rate was 0.055 L/mg volatile suspended solids (VSS)/day. The enrichment's T-RFLP profile was comprised largely of Desulfovibrio-like fragments, and Desulfovibrio species are known to reduce sulfate and U(VI). A second line of enrichments, inoculated from the sulfate-amended enrichment, was maintained without sulfate. After four transfers of the sulfate-free culture, it was found unable to reduce U(VI). This culture's T-RFLP profile was largely comprised of Clostridia-like fragments, and Clostridia ferment ethanol to acetate. The results indicate a sulfate requirement for the growth of U(VI)-reducing organisms in this community.
Real-time Simulation and Visualization of deformable Objects (2008)

In this thesis, I present a framework for physical simulation and visualization of deformable volumetric bodies in real time. Based on the implicit finite element method a multigrid approach for the efficient numerical simulation of elastic materials has been developed. Due to the optimized implementation of the multigrid scheme, 200,000 elements can be simulated at a rate of 10 time steps per second. The approach enables realistic and numerically stable simulation of bodies that are described by tetrahedral or hexahedral grids. It can efficiently simulate heterogeneous bodies---i.e., bodies that are composed of material with varying stiffness---and includes linear as well as non-linear material laws. To visualize deformable bodies, a novel rendering method has been developed on programmable graphics hardware. It includes the efficient rendering of surfaces as well as interior volumetric structures. Both the physical simulation framework and the rendering approach have been integrated into a single simulation support system. Thereby, available communication bandwidths have been efficiently exploited. To enable the use of the system in practical applications, a novel approach for collision detection has been included. This approach allows one to handle geometries that are deformed on the graphical subsystem.
The role of β-glucuronidase in disposition and anti-inflammatory effects of urolithins- gut microbiota-derived metabolites of ellagitannins. (2017)

The gut microbiota metabolism of orally applied natural products has been in recent years indicated as an important factor significantly influencing their therapeutic effects. One of the most extensively studied groups of compounds are ellagitannins, which are metabolized to urolithins- compounds having good bioavailability and being detected in plasma and urine at micromolar concentrations following oral intake of ellagitannin-containing products. In vivo studies conducted for these natural products clearly indicate beneficial health effects towards inflammation-related diseases, which are associated with the formation of urolithins. However, since the majority of in vitro experiments was conducted for urolithin aglycones, they occur incongruent with the results of recent pharmacokinetic studies clearly indicating that glucuronide conjugates are the dominant metabolites present in plasma, tissue and urine [1].
Brass Tone Synthesis by Spectrum Evolution Matching with Nonlinear Functions (1979)

There has been ample evidence from analytical studies done in recent years that brass harmonic spectra (and probably those of other wind instruments) are somehow related to spectra which can be produced by the nonlinear distortion of a variable amplitude sine wave. It is the purpose of this paper to review this evidence and present some results of attempts to synthesize brass tones using this technique.
Clinical applications of corneal confocal microscopy (2008)

Corneal confocal microscopy is a novel clinical technique for the study of corneal cellular structure. It provides images which are comparable to in-vitro histochemical techniques delineating corneal epithelium, Bowman's layer, stroma, Descemet's membrane and the corneal endothelium. Because, corneal confocal microscopy is a non invasive technique for in vivo imaging of the living cornea it has huge clinical potential to investigate numerous corneal diseases. Thus far it has been used in the detection and management of pathologic and infectious conditions, corneal dystrophies and ecstasies, monitoring contact lens induced corneal changes and for pre and post surgical evaluation (PRK, LASIK and LASEK, flap evaluations and Radial Keratotomy), and penetrating keratoplasty. Most recently it has been used as a surrogate for peripheral nerve damage in a variety of peripheral neuropathies and may have potential in acting as a surrogate marker for endothelial abnormalities.
Bis[N,N′-diisopropyl-N-(trimethylsilyl)benzamidinium] di-μ-chloro-bis[tetrachlorozirconate(IV)] dichloromethane disolvate (2003)

The structure of the salt of the di-mu-chloro-bis[tetrachlorozirconate(IV)] anion and the N,N'-isopropyl-N-(trimethylsilyl)benzamidinium cation, (C(16)H(29)N(2)Si)(2)[Zr(2)Cl(10)].2CH(2)Cl(2), is reported. The anion lies about an inversion centre and shows a substantially octahedral coordination around Zr, while the structure of the cation is unequivocally assigned as that of a benzamidinium ion.
57‐3: Folded Pixel Circuit Design in Grain‐Boundary Free (100) Oriented LTPS Stripes Fabricated by Selective CW‐laser Lateral Crystallization (2018)

Effects of scan conditions on grain‐boundary‐free (100) oriented LTPS films by the CW laser lateral crystallization were investigated. Overlapped scans generated grain‐boundaries at the scan regions. A new selective one‐time scan was proposed for high precision mobile OLED panels, where LTPS circuits of neighboring pixels were folded along the scan.
Effects of age and smoking on endothelial function assessed by quantitative cardiovascular magnetic resonance in the peripheral and central vasculature (2015)

Results suggest CMR biomarkers of endothelial function to be sensitive to age and smoking independent of each other.
Effects of the dipole moment on charge transport in disordered molecular solids (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of the dipole moment on charge transport in disordered molecular solidsPaul M. Borsenberger and John J. FitzgeraldCite this: J. Phys. Chem. 1993, 97, 18, 4815–4819Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/j100120a038https://doi.org/10.1021/j100120a038research-articleACS PublicationsRequest reuse permissionsArticle Views887Altmetric-Citations138LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Enhanced light output of an InGaN/GaN light emitting diode with a nano-roughened p-GaN surface (2005)

This investigation describes the development of an InGaN/GaN light emitting diode (LED) with a nano-roughened top p-GaN surface using an Ni nano-mask and laser etching. The light output of the InGaN/GaN LED with a nano-roughened top p-GaN surface is 1.55 times that of a conventional LED, and the wall-plug efficiency is 68% higher at 20 mA. The series resistance of the InGaN/GaN LED was reduced by 32% by the increase in the contact area of the nano-roughened surface.
Non-Electrolytic Formation of Al-Oxide Surface Layers by Reversion of Hydrotalcite (1998)

Abstract Polycrystalline hydrated aluminum oxide coatings with high corrosion resistance have been produced on Al alloys using non-toxic, non-electrolytic methods. These coatings are formed by a two stage process consisting of immersion in an alkaline Li-salt solution to form a hydrotalcite coating followed by immersion in boiling distilled water. Immersion in boiling water transforms the hydrotalcite to hydrated aluminum oxide (bayerite). This process has been termed “reversion”. Reversion coatings can be formed in 30 minutes or less and exhibit corrosion resistances near that of anodized coatings. Reversion coating morphology, structure and composition are presented. The corrosion resistance of reversion coatings is compared to the corrosion resistance of coatings produced by chromate conversion and electrolytic anodization.
Speciation of Gold Nanoparticles by Ex Situ Extended X-ray Absorption Fine Structure and X-ray Absorption Near Edge Structure (2016)

A combined X-ray absorption near edge structure (XANES) and extended X-ray absorption fine structure (EXAFS) methodology is here presented on a series of partially and fully reduced Au(III) samples. This allows monitoring the relative fraction of Au(III) and Au(0) in the studied samples, displaying a consistent and independent outcome. The strategy followed is based, for the first time, on two structural models that can be fitted simultaneously, and it evaluates the correlation among strongly correlated parameters such as coordination number and the Debye-Waller factor. The results of the present EXAFS and XANES approach can be extended to studies based on X-ray absorption spectroscopy experiments for the in situ monitoring of the formation of gold nanoclusters.
Cover Image, Volume 39, Issue 12 (2018)

On the Front Cover: This cover image is based on the Research Article The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function by Martina Proietti Onori et al., Pages 2008–2024. DOI: 10.1002/humu.23647.
<title>Absolute phase measurement with extrinsic Fabry-Perot optical fiber sensors</title> (1996)

This paper describes the use of the first and second optical return paths in a moderate to high finesse Fabry-Perot sensor to measure the absolute phase in extrinsic Fabry- Perot interferometric (EFPI) sensors. Path-matched differential interferometry (PMDI) using high finesse EFPI sensors, a low finesse Fabry-Perot read-out interferometer, and a broadband light source consisting of amplified spontaneous emission (ASE) from an erbium-doped fiber amplifier (EDFA) is used to illustrate the idea. The first and second multiple paths in the Fabry-Perot read-out sensor are used to provide two distinct path-match conditions from the same scanning Fabry-Perot read-out interferometer. The difference in fringe numbers between the centers of two orders of interference fringe packets formed by the distinct path-match conditions makes possible a simple method of measuring the cavity length of EFPI sensors, which in turn can be used to measure absolute phase and the corresponding strain. Sensor cavity length measurement using the multiple return paths in the high finesse Fabry-Perot sensor is compared with measurements made using the modulation transfer function found using an optical spectrum analyzer. Then the multiple return path technique is then used to make strain measurements on a cantilever beam. Comparisons with resistance strain gate measurements are favorable. Characterization tests indicate that the proposed technique has a cavity length measurement resolution on the order of 1.1. micrometer, which translates to a strain resolution of 28 (mu) (epsilon) for a 4 cm gage length sensor.
Laser ionization spectroscopy of CD/sub 3/ via the 3p/sub z/ /sup 2/A''/sub 2/ Rydberg state (1989)

Nascent CD/sub 3/ radicals produced by photodissociation of CD/sub 3/I after absorption of 266 nm radiation by the A-italic-tilde state are studied using the photofragment imaging technique. Two-photon, resonance-enhanced, multiphoton ionization ((2+1) REMPI) probes CD/sub 3/ via the 3p/sub z/ /sup 2/A'/sub 2/ Rydberg excited electronic state. CD/sub 3/I photodissociation at 266 nm is found to produce ground-electronic-state CD/sub 3/ radicals with substantial vibrational excitation of the ..nu../sub 2/ umbrella mode. Rotational constants are determined for v = 0, 1, and 2 of ..nu../sub 2/ in the 3p/sub z/ excited state by analysis of the spectra. A first-order perturbation and diagonalization procedure is used to generate potential energy curves for the umbrella mode in both the ground and excited electronic states and Franck--Condon factors for various transitions between the states. These results should prove useful when employing REMPI to characterize methyl radicals in many environments.
Void dynamics in low pressure acetylene plasmas (2014)

We studied a capacitively coupled RF plasma with constant flow of argon and acetylene. These plasmas are able to spontaneously form dust particles under certain conditions, resulting in a cloud of particulates up to micrometer sizes levitated in the plasma. After the dust cloud has been formed, a region without dust develops. This dust-free zone is roughly shaped as an ellipsoid and is referred to as void. Concurrently, the dust particles grow in size. During its expansion the void suddenly stops growing and even shrinks, to shortly thereafter resume its expansion. We dubbed this the ‘hiccup’. The processes are periodical and reproducible. Several techniques that are time resolved (microwave cavity resonance spectroscopy, plasma impedance monitoring) and in addition spatially resolved (laser scattering, emission analysis) are used to shed light on the intriguing phenomenon. We infer the hiccup is induced by coagulation of a new batch of dust particles inside the void.