gebhart/patrepeval huggingface dataset:
CD44 Expression by Leucocytes in Rheumatoid Arthritis and Modulation by Specific Antibody: Implications for Lymphocyte Adhesion to Endothelial Cells and Synoviocytes In Vitro (1997)

Anti-CD44 MoAb IM7 induced the loss of CD44 from mouse leucocytes thereby inhibiting leucocyte migration and joint inflammation in murine arthritis. Thus, targeting CD44 with MoAb may have potential for the treatment of patients with inflammatory joint diseases. Expression of CD44 by peripheral blood (PB) and synovial fluid (SF) leucocytes from rheumatoid arthritis (RA) patients was compared and the ability of IM7 to modulate this expression determined. RASF lymphocytes showed increased CD44 expression compared with those in PB indicative of an activated phenotype. As inflammatory SF did not up-regulate CD44 expression on PB lymphocytes, the increased CD44 expression by SF lymphocytes was a result of the selective homing of CD44(high) cells to the synovium rather than an effect of the synovial environment. RASF granulocytes showed reduced CD44 expression compared with those in PB, again indicative of an activated phenotype. However, this reduction could be induced on PB granulocytes following culture with inflammatory SF and was inhibited by anti-TNF-alpha MoAb, implying that soluble factors in inflammatory SF such as TNF-alpha induced granulocyte activation and CD44 loss. IM7 induced the loss of CD44 from lymphocytes (both from PB and SF) and granulocytes in vitro, but was subsequently re-expressed after 24 h culture in the absence of the MoAb. This loss of CD44 was blocked by serine- and metalloprotease inhibitors implying that IM7 induced the proteolytic cleavage of CD44 by a mechanism similar to that reported for the loss of CD44 from PMA-activated granulocytes. Furthermore, IM7-treated CD44(low) lymphocytes showed reduced adherence to both an endothelial cell line and RA synovial fibroblasts in vitro. The unique ability of IM7 to reduce CD44 expression by lymphocytes suggests that it could prevent lymphocyte extravasation and synovial infiltration in RA as previously reported in murine arthritis.
No linkage of P187S polymorphism in NAD(P)H: Quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population (1999)

Recent genome screening studies have identified novel regions of possible interest for susceptibility to type 1 diabetes. One of these is a 30-35 cM region mapping to 16q22-q24 (D16S515-D16S520), where also the gene encoding NAD(P)H: quinone oxidoreductase (NQO1) maps. Data has suggested association of a polymorphism (P187S) in the NQO1 gene and type 1 diabetes. NQO1 is involved in protection against oxidative stress, which is likely to be involved in beta-cell destruction. By use of the transmission disequilibrium test (TDT), we analyzed the P187S polymorphism for association to type 1 diabetes in a population-based sample of 247 Danish nuclear type 1 diabetic families. Random transmission patterns were observed to all affected offspring (p(tdt) = 0.82), to index cases (P(tdt) = 0.77), as well as to unaffected offspring (P(tdt) = 0.93). Hence, the NQO1 polymorphism is not likely to be an etiological mutation underlying the reported linkage of the 16q22-q24 region.
Advanced EMR Technology (1992)

&lt;div class="htmlview paragraph"&gt;New EMR technologies have been developed in response to customer demand for better process control and reliability. In hand riveting of large panels visual contact between operators is blocked. A reliable means was required to insure that guns could only discharge when properly deployed upon opposing ends of the rivet. A second problem is to satisfy the demand for improved process control in EMR operation. These goals were achieved by implementing a fully digital control scheme for the EMR operation. These new technologies are covered in this paper.&lt;/div&gt;
A proof of existence of whiskered tori with quasi flat homoclinic intersections in a class of almost integrable hamiltonian systems (1995)

Article A proof of existence of whiskered tori with quasi flat homoclinic intersections in a class of almost integrable hamiltonian systems was published on January 1, 1995 in the journal Forum Mathematicum (volume 7, issue Jahresband).
Bacterial Cellulose Scaffolds and Cellulose Nanowhiskers for Tissue Engineering (2013)

As the principle structural polysaccharide in plants, cellulose has been extensively characterized over many decades. In recent years, however, exciting new cellulosic materials have been developed with nanoscale fibrillar structures that have particularly promising applications in the growing field of tissue engineering. The majority of recent studies on cellulose nanomaterials for tissue engineering have employed bacterial cellulose, a material with a profile of properties unique among biomaterials commonly used in tissue engineering scaffolds. In addition, a number of recent studies have explored the biomedical applications of discrete colloidal nanocellulose fibrils known as cellulose nanowhiskers or cellulose nanocrystals. The literature on bacterial cellulose scaffolds for tissue engineering is reviewed, and studies on the biocompatibility of cellulose nanowhiskers and their potential for tissue engineering are discussed. Challenges for future development of these materials and potential future advances are also considered.
Orbital-Angular-Momentum-Based Reconfigurable and “Lossless” Optical Add/Drop Multiplexing of Multiple 100-Gbit/s Channels (2013)

We propose reconfigurable optical add/drop multiplexing in a data link using orbital angular momentum (OAM) mode division multiplexing. Adding/dropping of one OAM mode from three multiplexed OAM modes, each carrying 100 Gbit/s QPSK data is demonstrated, with an OSNR penalty of &lt; 2dB.
Enhanced reactivity of dicalcium phosphate dihydrate with fluoride ions by coating with apatite nanoparticles (2021)

The formation of nanoscale precursors on the surface of dicalcium phosphate dihydrate (DCPD) is an important step in various methods; however, this process requires an unstable solution. Herein, we propose a simple method for the deposition of nanoscale fluorapatite (FAp) particles on the surface of DCPD particles using a weakly acidic, aqueous solution containing only calcium, phosphate, and fluoride ions (C-P-F solution). Repeated immersion in the same solution increases the amount of FAp deposition and almost no delay time is observed. Experimental results indicate that approximately 10 wt.% of FAp on the DCPD surface is optimal to enhance its reactivity with fluoride ions. Our results demonstrate an optimum FAp deposition amount on DCPD particles for improved reactivity with fluoride ions, and we achieved an improved surface of the DCPD particle for fluoride immobilization in wastewater and soil environments.
Multi-scale modeling and synthesis of polyester ionomers (2013)

Simulations of microphase separation are carried out using the dissipative particle dynamics (DPD). By varying the concentration and temperature of resin solutions we explore mesomorphologies supported by the all-atom models. We found that for a low degree of functionalization the homogeneously distributed ionomers self-assemble into spherical micelles at solid loads below 31 wt%, subject to the activation energy barrier for the gradual growth of pre-micellar aggregates. Computed optimum aggregation numbers exhibit sensitivity to both the temperature-dependent interfacial tension and the ionic content and compare well with the experimental observations.
Using Silica Sol as a Nanoglue to Prepare Nanoscale Mesoporous Composite Gel and Aerogels (2000)

A composite gel or aerogel is formed by commingling a particulate guest (such as a colloidal or dispersed (i.e., non-colloidal) solid or a powder) with a sol which is either about to gel or in which gelation has just started. After addition of the particulate, the mixture is then permitted to gel into a solid, gelled composite with open pores. This solid, gelled composite is then dried in a manner that prevents the collapse of open pores within the solid, gelled composite in which the gel acts as a nanoglue that holds the particles together.
The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: Phase 2 methodological report (2020)

The American College of Rheumatology and the European League Against Rheumatism have developed new classification criteria for rheumatoid arthritis (RA). The aim of Phase 2 of the development process was to achieve expert consensus on the clinical and laboratory variables that should contribute to the final criteria set.
Simulation of Matrix-Fracture Interaction in Low-Permeability Fractured Unconventional Reservoirs (2017)

Abstract Unconventional reservoirs, such as shale-gas or tight-oil reservoirs, are generally highly fractured, including hydraulic fractures, stimulated and non-stimulated natural fractures of various sizes, embedded in low-permeability formations. One of the main production mechanisms in unconventional reservoirs is the flow exchange between matrix and fracture media. However, due to extremely-low matrix permeability, the matrix/fracture exchange is very slow and the transient flow may last several to tens of years, i.e. almost the entire production life. The commonly-used dual-porosity modelling approach involves a computation of pseudo-steady-state matrix-fracture transfers with homogenized fluid and flow properties within the matrix medium. This kind of model clearly fails to handle the long-lasting matrix/fracture interaction in very-low permeability reservoirs, especially for multi-pahse flow with phase change problems. Moreover, a dual-porosity model is not adapted for the simulation of matrix/fracture exchange when fractures are described by a DFN (Discrete Fracture Network). This paper presents an EDFM (Embedded Discrete Fracture Model) based on the MINC (Multiple INteracting Continua) proximity function to overcome this insufficiency of the conventional dual-porosity model.
Model-based OPC for phase-shifter edge lithography (2002)

Phase shifter edge lithography (double-exposure method) provides improved image contrast and lithographic resolution. However, it is subject to the problems of optical proximity effects. Therefore, to make this technique practical for use in device manufacturing, it is necessary to understand the characteristics of optical proximity effects and through such understanding establish a practical OPC (Optical Proximity Correction) method to correct them. Since the size of both the phase shift mask (PSM) and the trim mask (a mask used to form a rough gate pattern) significantly affect the wafer CD (critical dimension), an OPC tool which takes the layout of the two masks into account is required. Due to the difficulty in describing a rule-table for both masks, a model-based approach is a suitable means to develop such a tool. A PSM and a trim mask are used to calculate aerial images. In a double-exposure approach, however, mask shape does not define the desired shape. Therefore, an additional layer which defines the desired shape has been introduced. The desired shape is also used to consider the etching effect, which is described in a rule-table and applied to the original layout. With this approach, the desired shape defines the resist shape. To improve computing time, we apply model-based OPC only to specified areas, and rule-based OPC outside of those areas. Because of the large amount of data that must be processed, the designed layout is divided into fractions and compute on a multi-processor system. Previously, we reported improvements in pattern-matching methods to reduce the simulation time. In this paper, we report full-chip- correction performance and results of OPC technology.
Elliptic Curve Signcryption with Encrypted Message Authentication and Forward Secrecy (2009)

Summary This paper presents a comprehensive signcryption scheme based on elliptic curves. In addition to the message confidentiality, nonrepudiation and unforgeability, the proposed scheme achieves forward secrecy and encrypted message authentication needed by firewalls. A judge can resolve disputes by directly verifying the sender’s signature on signcrypted messages without help from the sender and without decrypting the message. Firewalls can securely filter signcrypted messages passing through them without having to do full unsigncryption to verify the sender’s identity. If the sender’s long-term key is compromised, the previous messages signcrypted with that key remain confidential. Elliptic curves are used for their security, key size and bandwidth advantages. The proposed scheme combines these security properties with savings in computational complexity and bandwidth overhead.
4'-Phosphopantetheine, a Cofactor Bound to Guanosine Triphosphate-dependent Acyl Coenzyme A Synthetase (1970)

A small molecular weight cofactor has been isolated from purified preparations of the guanosine triphosphate-spectic acyl coenzyme A synthetase of rat liver mitochondria.The synthetase enzyme becomes inactive on removal of the cofactor, and its characteristic activity is restored by adding back the cofactor to the complete system containing Coi-SH.In its active form, the cofactor possesses sulfhydryl groups, organic phosphate, and pantothenic acid in a ratio of 1: 1: 1.4'-Phosphopantetheine can replace the cofactor in all enzymic assays and shares with the cofactor all chemical and spectral characteristics.
A rationale for assessing the lower-body power profile in team sport athletes (2013)

Training at the load that maximizes peak mechanical power (Pmax) is considered superior for the development of power. We aimed to identify the Pmax load ('optimal load') in the jump squat and to quantify small, moderate, large, and very large substantial differences in power output across a spectrum of loads to identify loads that are substantially different to the optimal, and lastly, to investigate the nature of power production (load-force-velocity profiles). Professional Australian Rules Football (ARF; n = 16) and highly trained Rugby Union (RU; n = 20) players (subdivided into stronger [SP] vs. weaker [WP] players) performed jump squats across incremental loads (0-60 kg). Substantial differences in peak power (Wkg21) were quantified as 0.2-2.0 of the log transformed between-athlete SD at each load, backtransformed and expressed as a percent with 90% confidence limits (CL). A 0-kg jump squat maximized peak power (ARF: 57.7 ± 10.8 Wkg21; RU: 61.4 ± 8.5 Wkg21; SP: 64.4 ± 7.5 Wkg21; WP: 54.8 ± 9.5 Wkg21). The range for small to very large substantial differences in power output was 4.5-55.9% (CL: 3/O1.36) and 2.8-32.4% (CL: 3/O1.31) in ARF and RU players, whereas in SP and WP, it was 3.7-43.1% (CL: 3/O1.32) and 4.3-51.7% (CL: 3/O1.36). Power declined per 10-kg increment in load, 14.1% (CL: 61.6) and 10.5% (CL: 61.5) in ARF and RU players and 12.8% (CL: 61.9) and 11.3% (CL: 61.7) in SP and WP. The use of a 0-kg load is superior for the development of jump squat maximal power, with moderate to very large declines in power output observed at 10-to 60-kg loads. Yet, performance of heavier load jump squats that are substantially different to the optimal load are important in the development of sport-specific force-velocity qualities and should not be excluded.
Classical Boltzmann Theory of Cyclotron Resonance for Warped Surfaces (1957)

A classical Boltzmann model of cyclotron resonance with an energy-independent collision time is developed. An approximate solution of the Boltzmann equation is obtained by expanding the perturbed distribution function $\ensuremath{\Phi}(p, \ensuremath{\Theta}, \ensuremath{\varphi})$, in a Fourier series in $\ensuremath{\varphi}$, where the spherical coordinates are defined with the polar axis along the magnetic field direction. The solution yields a fundamental cyclotron resonance absorption line, which shows line shape anisotropy, as well as a shift in resonance peak with magnetic field direction. The theory also indicates resonance absorption at harmonics of the fundamental cyclotron resonance frequency, due to the warping of the constant-energy surfaces. The results are applied to a calculation of line shapes and harmonic intensities for heavy holes in silicon and germanium.
Properties of charge carriers in ZnS and their effect on the excitation of Mn (1997)

Abstract— The subjects of this investigation are the transport of charge carriers and the spatial efficiency in thin‐film electroluminescent devices based on ZnS: Mn. Measurements with optional UV illumination were performed on a set of probe layer samples. The transfer of electrons and holes was studied and by comparing transient measurements with the steady‐state situation the creation of positive space charge during the first pulses is revealed and its location is estimated.
Structuring the student research experience (2000)

The benefits of working in a research group are clear: students develop domain expertise, gain an understanding and appreciation of the research process and its practice, and acquire team, communication, problem-solving, and higher-level thinking skills. Students with this experience are better equipped to make informed judgments about technical matters and to communicate and work in teams to solve complex problems. However, it is difficult to provide a quality experience to large numbers of students, particularly to students of differing abilities.The Systems and Software Engineering Affinity Research Group model provides a socialization mechanism and infrastructure that supports the development and management of large research groups that engage undergraduate and graduate students, who have a wide range of skill levels and experiences, in research and projects. This non-hierarchical model integrates students into both small research groups and an encompassing large research group, and uses structured activities to develop their research, technical, communication, and group skills.In this paper we introduce the model and report how the model meets independently developed Best Practice guidelines for student research experiences and we provide indicators of success for use by other projects.
Channel Profile Independent Usage of Convolutional Neural Networks for Receiver Chain Optimization (2020)

One of the most innovative techniques is using convolutional neural networks (CNNs) for predicting and pre-scheduling the different tasks in the receiver chain. Using CNNs as a pre-processor leads to optimizing receiver efficiency to maximize packet transmission reliability while minimizing the complexity of receiver processing. This state of art technique showed high accuracy using a supervised deep learning classification for raw base-band packets. Although the approach is considered a blind technique, in literature it is dependent on the channel power delay profile (PDP). i.e. there are different CNNs for each channel profile with fixed Doppler frequency shifts. Besides that, for some channel profiles, there is an overfitting problem that leads to performance degradation at higher SNR levels. Here we propose a solution for both issues, first by introducing regularization to eliminate the over-fitting problem appeared in literature, then we introduce a channel profile independent approach which significantly reduces the system complexity by replacing multiple CNNs with one and eliminating the need for prior identification of channel's PDP. And finally, we propose also an SNR values-based order training technique that allows tuning the performance vs SNR.
Flexible, Free-Standing Polymer Membranes Sensitized by CsPbX3 Nanocrystals as Gain Media for Low Threshold, Multicolor Light Amplification (2022)

Lead halide perovskite nanocrystals (NCs) are highly suitable active media for solution-processed lasers in the visible spectrum, owing to the wide tunability of their emission from blue to red via facile ion-exchange reactions. Their outstanding optical gain properties and the suppressed nonradiative recombination losses stem from their defect-tolerant nature. In this work, we demonstrate flexible waveguides combining the transparent, bioplastic, polymer cellulose acetate with green CsPbBr<sub>3</sub> or red-emitting CsPb(Br,I)<sub>3</sub> NCs in simple solution-processed architectures based on polymer-NC multilayers deposited on polymer micro-slabs. Experiments and simulations indicate that the employment of the thin, free-standing membranes results in confined electrical fields, enhanced by 2 orders of magnitude compared to identical multilayer stacks deposited on conventional, rigid quartz substrates. As a result, the polymer structures exhibit improved amplified emission characteristics under nanosecond excitation, with amplified spontaneous emission (ASE) thresholds down to ∼95 μJ cm<sup>-2</sup> and ∼70 μJ cm<sup>-2</sup> and high net modal gain up to ∼450 and ∼630 cm<sup>-1</sup> in the green and red parts of the spectrum, respectively. The optimized gain properties are accompanied by a notable improvement of the ASE operational stability due to the low thermal resistance of the substrate-less membranes and the intimate thermal contact between the polymer and the NCs. Their application potential is further highlighted by the membrane's ability to sustain dual-color ASE in the green and red parts of the spectrum through excitation by a single UV source, activate underwater stimulated emission, and operate as efficient white light downconverters of commercial blue LEDs, producing high-quality white light emission, 115% of the NTSC color gamut.
Modular blue fluorescent RNA sensors for label-free detection of target molecules (2010)

A blue fluorescent RNA was applied to modular blue fluorescent RNA sensors, wherein a "recognition" event of the target molecule by the aptamer domain is transmitted through a "communication" module, to a "signaling" fluorescent RNA domain, which "lights up".