gebhart/patrepeval huggingface dataset:
Plasma membrane localization of paralogous leucine permeases Bap2 and Bap3 is regulated by Bul1 (2020)

Abstract Timeliness in expression and degradation of the nutrient permeases is crucial for any organism. In Saccharomyces cerevisiae , post translational regulation of nutrient permeases such as trafficking and turnover are poorly understood. We found that loss of a leucine permease BAP2 , but not other permeases lead to severe growth retardation when the carbon source is glucose or galactose but not glycerol and lactate. Leucine prototrophy suppressed the retardation, showing BAP2 and LEU2 are synthetically lethal. We discovered that loss of BUL1 , an arrestin involved in trafficking of diverse permeases suppressed this lethality. The suppression required another leucine permease, BAP3 . Our results suggest that BUL1 downregulate permeases BAP2 and BAP3 present in plasma membrane through Rsp5 dependent endocytosis. We speculate that by regulating leucine import BUL1 regulates the activity of TORC1.
Prevalence of fatty liver in a general population of Okinawa, Japan. (1988)

A total of 2,574 residents in Yaeyama District of Okinawa, Japan, were investigated using real time ultrasonography to determine the real prevalence of fatty liver in the general population and to define its associated factors. Overall prevalence of fatty liver was 14.0%. Prevalence of fatty liver in persons under 19 years old was only 1.2%, and increased with age to a maximum in persons 40-49 years of age and then decreased. For persons over 20 years old, obesity index and serum levels of triglyceride and total cholesterol were measured, and alcohol consumption was asked. Prevalence of fatty liver was significantly higher in drinkers than non-drinkers (p less than 0.01), and increased with alcohol consumption. Furthermore, in persons not suffering from obesity prevalence of fatty liver was significantly higher in drinkers than in non-drinkers (p less than 0.001). The results of logistic regression analysis indicated that obesity and elevated serum triglyceride level in both sexes, and alcohol in males were significant predictors of fatty liver. In conclusion, prevalence of fatty liver increased with age to a maximum in persons 40-49 years of age and overall was 14.0%. Obesity was the strongest associated factor in both sexes and in males alcohol was also a strong factor.
Encapsulant Materials for High Reliable Bifacial Heterojunction Glass/Glass Photovoltaic Modules (2020)

The main objective of the European project AMPERE was the implementation of a 200 MWp fully automated glass/glass bifacial photovoltaic module pilot line based on silicon heterojunction technology. In this work, the results of the compatibility assessment of different commercial encapsulants with the new module design are presented. The study has been conducted by first testing the durability of each encapsulant and its interaction with the interconnected cells. Later the results have been transferred and validated for full size (72cells) modules by an extended and sequential stress testing sequence. The study showed that polyolefin elastomers are more compatible to heterojunction technology than other commercial encapsulants.
Higher-Level Paradigms for Deadlock-Free High-Performance Systems (1993)

Ab3hact. Tlis is a study rsviewing and developins m.thodolosi * esseatial to ensineels who need io develop low-cost lal ligh-p.llolmance codputins applications. Emersins studalds will lequire lhe adoplion of techniqnes that ofier perfo.nance and se.uliiy lo a lev€l ai l€st lhat provid.d by tlE m.thodolDsies p.esented in ihG 6ludy for n$s nuket enbedded appLicalions Md other a!es. Ou neilodolosiG.re bded upon th. multiprocessing compuiiAg model defrned by CSP atrd irlesiaied wiiiin the occam proeranhins ldn8u!9.. TIb study is lhe.esult of joiri coopelation beiweed rd€archeB and industrial useB in rhe gI ( (u veBiiy of Ke nr, wno lurhored thG srudy) and rhe Nerhensnds (univ*siry ot Twenle and Rierschoren &amp;amp; Eouwers. Rotteidm). This study rcvi.ws rhe gen€ral notion ol deadlock (and livelock) in ptual€l syF tems bded lpon synchlonis.d n.$agc pNnl8 and r.llles lhem to ile mrb wo.se problem of udetected daia-lN in ayRchronous or shar.d-meno.y conmnnicalions. Two d€sisn p*adi8m (I/o-PAR s^d cli.nr.s.ru.&amp;apos;) are prdenied r [ suaruiee Iredon frcn deadloc! Io. synchronG.d connunicalion r€siDe (both corlinuous d nr€sular dara,flo*). Th. pa6dism3 lre bsed lpon lh. lotion oI &amp;apos;synchrods&amp;amp; tion das&amp;apos;for proc * th.l ie clG€d ulder c..lain torms of p&amp;amp;ail€l compcition. Chcking for deadlock-f.eens d.votv6 io ch.clins lhd ih. bNe?roc66 bdon6 io the corrci dN6 rd liat-ti. conp6iiion tu16 rr. obelved. Tle complexity of this cheding is at wo6i O(n&amp;apos;), wh.r. tr is lh. nunber
ChemInform Abstract: SILAETHENES. VIII. GAS‐PHASE PYROLYSIS OF SILICON‐HALOGENATED SILACYCLOBUTANES (1982)

Abstract Die Gasphasenpyrolyse der siliciumhalogenierten Silacyclobutane (I) und (II) wird unter verschiedenen Bedingungen untersucht.
RADBALL TECHNOLOGY TESTING IN THE SAVANNAH RIVER SITE HEALTH PHYSICS INSTRUMENT CALIBRATION LABORATORY (2010)

The United Kingdom's National Nuclear Laboratory (NNL) has developed a radiation-mapping device that can locate and quantify radioactive hazards within contaminated areas of the nuclear industry. The device, known as RadBall{trademark}, consists of a colander-like outer collimator that houses a radiation-sensitive polymer sphere. The collimator has over two hundred small holes; thus, specific areas of the polymer sphere are exposed to radiation becoming increasingly more opaque in proportion to the absorbed dose. The polymer sphere is imaged in an optical-CT scanner that produces a high resolution 3D map of optical attenuation coefficients. Subsequent analysis of the optical attenuation data provides information on the spatial distribution of sources in a given area forming a 3D characterization of the area of interest. The RadBallTM technology has been deployed in a number of technology trials in nuclear waste reprocessing plants at Sellafield in the United Kingdom and facilities of the Savannah River National Laboratory (SRNL). This paper summarizes the tests completed at SRNL Health Physics Instrument Calibration Laboratory (HPICL).
Innovative Relentlessly: Enabling Innovation in Aviation While Respecting Its Safety Tradition (2018)

An overview of UTM (UAS (Unmanned Aircraft Systems) Traffic Management) and UAM (Urban Air Mobility).
New approaches to whisker free tin deposits (2004)

In view of their different whisker growth propensities, tin-plated C19400 and C70250 copper lead-frame materials were investigated by atomic force microscopy (AFM) with regard to their intermetallic compound (IMC) characteristics. It was observed that both rate of formation and morphology are distinctively different from each other, whereby approximately twice the amount of IMC formed with C70250 than with C19400. The resultant IMC morphology from both materials consists of a ubiquitous thin IMC layer interspersed with relatively large pyramid-shaped IMC grains. These large grains have formed along the grain boundaries of the tin deposit, whereas the thin part of the IMC layer has grown at the base of the tin grains. The density of the large IMC grains is significantly higher with C70250 than with C19400. This difference is correlated to the tin whisker characteristics of the two tin-plated substrates. A higher density of large IMC grains that results in a reduction of whisker growth is also achieved by tin electrodeposits that show a characteristic crystal texture.
Mechanical and Electrophysiological Properties of the Sarcolemma of Muscle Fibers in Two Murine Models of Muscle Dystrophy: Col6a1−/−and Mdx (2010)

This study aimed to analyse the sarcolemma of Col6a1-/- fibers in comparison with wild type and mdx fibers, taken as positive control in view of the known structural and functional alterations of their membranes. Structural and mechanical properties were studied in single muscle fibers prepared from FDB muscle using atomic force microscopy (AFM) and conventional electrophysiological techniques to measure ionic conductance and capacitance. While the sarcolemma topography was preserved in both types of dystrophic fibers, membrane elasticity was significantly reduced in Col6a1-/- and increased in mdx fibers. In the membrane of Col6a1-/- fibers ionic conductance was increased likely due to an increased leakage, whereas capacitance was reduced, and the action potential (ap) depolarization rate was reduced. The picture emerging from experiments on fibers in culture was consistent with that obtained on intact freshly dissected muscle. Mdx fibers in culture showed a reduction of both membrane conductance and capacitance. In contrast, in mdx intact FDB muscle resting conductance was increased while resting potential and ap depolarization rate were reduced, likely indicating the presence of a consistent population of severely altered fibers which disappear during the culture preparation.
Accelerated Bone Loss in Older Men: Effects on Bone Microarchitecture and Strength (2018)

Accelerated bone loss (ABL) shown on routine dual-energy X-ray absorptiometry (DXA) may be accompanied by microarchitectural changes, increased cortical porosity, and lower bone strength. To test this hypothesis, we performed a cross-sectional study and used high-resolution peripheral quantitative computed tomography (HR-pQCT) scans (Scanco Medical AG, Brüttisellen, Switzerland) to measure estimated bone strength and microarchitecture in the distal radius and distal and diaphyseal tibia. We studied 1628 men who attended the year 14 exam of the Osteoporotic Fractures in Men (MrOS) study. We retrospectively characterized areal bone mineral density (aBMD) change from the year 7 to year 14 exam in three categories: "accelerated" loss, ≥10% loss at either the total hip or femoral neck (n = 299, 18.4%); "expected" loss, <10% (n = 1061, 65.2%), and "maintained" BMD, ≥0% (n = 268, 16.5%). The ABL cut-off was a safety alert established for MrOS. We used regression models to calculate adjusted mean HR-pQCT parameters in men with ABL, expected loss, or maintained BMD. Men who experienced ABL were older and had a lower body mass index and aBMD and experienced greater weight loss compared with other men. Total volumetric BMD and trabecular and cortical volumetric BMD were lower in men with ABL compared with the expected or maintained group. Men with ABL had significantly lower trabecular bone volume fraction (BV/TV), fewer trabeculae, and greater trabecular separation at both the distal radius and tibia than men with expected loss or who maintained aBMD, all p trend <0.001. Men with ABL had lower cortical thickness and lower estimated bone strength, but there was no difference in cortical porosity except at the tibia diaphyseal site. In summary, men with ABL have lower estimated bone strength, poorer trabecular microarchitecture, and thinner cortices than men without ABL but have similar cortical porosity. These impairments may lead to an increased risk of fracture. © 2018 American Society for Bone and Mineral Research.
Supplementary Table from Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma (2023)

Supplementary Table from Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma
<title>High-resolution LED printhead with uniformity compensation</title> (1990)

This paper describes the implementation and performance of high speed light-emitting-diode (LED) printheads. The printhead is essentially a line of LED''s the width of a page and is used for printing on ordinary paper using the electro-photographic process. The printhead design approach adopted by Optotek uses a modular construction with 256 bits per module and a resolution of 300 DPI allowing construction of different sizes using a common building block. The unique design allows uniformity compensation through pulse width modulation of LED drive currents giving nearly equal energy outputs for all pixels. Since the intensity is measured after the printhead has been completely assembled the measurements incorporate variations in drivers LED''s and optics. the intensity measurements are used to burn on board compensation EPROMS providing 4 bits of uniformity compensation for each pixel. A common control for average intensity adjustment is included. Units of various lengths have been provided to a number of printer manufacturers in North America Europe and Japan. A 6144 element printhead is presently in production. This unit operates at a peak LED emission wavelength of 667nm and provides a pixel power of 2. 5 through self focusing fiber optics. A separate serial digital interface for each module allows an effective bitrate of 200 MHz for this unit. The modular design permits implementation of higher resolutions. LED emission wavelength can be tailored to match spectral sensitivity of photoreceptors.
Dielectric, FTIR spectroscopic and atomic force microscopic studies on polypyrrole‐poly(acrylonitrile‐co‐vinyl acetate) composites (2011)

Abstract In this study, Poly(acrylonitrile‐ co ‐vinyl acetate) [P(AN‐ co ‐VAc)] composite films were fabricated by chemical polymerization of pyrrole (Py) with cerium(IV) (Ce(IV)) on P(AN‐ co ‐VAc) matrix. The effect of amount of Py and temperature on the composite film properties was studied in a frequency range starting from 0.05 Hz to 10 MHz and in a temperature range from 0 to 250°C. The electric modulus provides a good description of the dielectric relaxation of the conducting polymer composites. The atomic force microscopy images of the polypyrrole (PPy)‐P(AN‐co‐VAc) composites show the polymerization of Py on P(AN‐co‐VAc) matrix producing different sized grainy orientations resulting in higher conductivity values that increase with average grain size. The real [(ε′) or ε′(ω)] and imaginary [(ε″) or ε″(ω)] parts of the permittivity of PPy‐P(AN‐ co ‐VAc) composite were comparatively higher than PPy‐Polyacrylonitrile (PAN) and P(AN‐ co ‐VAc). It was also seen that the conductivity of PPy‐P(AN‐co‐VAc) composite was considerably higher than PPy‐PAN and P(AN‐co‐VAc) itself. POLYM. COMPOS., 2011. © 2011 Society of Plastics Engineers
Active Faults and Associated Tectonic Stress in the Coso Range, California. (1981)

The Coso Range contains faults that have been active in the Holocene. Some of these faults have moved about 100 years ago, possibly with the 1872 Owens Valley earthquake. Exploratory trenches exposed offsets up to 3.4 meters for one faulting event. Thus, a magnitude of 7.5 could be expected on these faults based on displacement vs. length equations. Recent local and regional earthquakes have caused property damage in the city of Ridgecrest. The tectonics of the Coso Range has been described as having arcuate and ring faults both of which suggest the presence of a circumscribed subsidence bowl or caldera-like feature. Data presented in this paper suggest the tectonism of the Coso Range is in transition between stresses from the right-slip San Andreas fault-plate interaction, and the extensional tectonics of the Basin in Range province. Arcuate faults in the Coso Range are interpreted to have been produced by the regional stress field rather than being from volcanogenic origin. Focal mechanisms of small-magnitude earthquakes support the stress directions indicated by local fault patterns. Fumeroles in the area are primarily associated with oblique-slip faults, rather than with arcuate or ring faults. The geothermal reservoir is, therefore, much different from that of a caldera or subsidence bowl, and the overall geothermal potential is probably less than the earlier estimates.
Reconstruction of Patterns of Differential Subsidence Using an Episodic Stratigraphic Model (1986)

Applying a general model of episodic stratigraphic accumulation, the Hypothesis of Punctuated Aggradational Cycles (PACs), it is possible to reconstruct patterns of differential subsidence within short time intervals in the Appalachian Foreland Basin. As small-scale (1–5 m thick) time-stratigraphic shallowing-upward cycles, PACs provide the necessary chronologic and palaeoenvironmental control for discriminating the amount of stratigraphic thickness attributable to differential subsidence. Correlation of PACs in the shallow carbonate facies of the Keyser Formation of central Pennsylvania permits precise determination of significant differential subsidence between localities only 60 km apart. Over this distance an 11·5 m difference in stratigraphic thickness (30 m versus 18·5 m) can be attributed to differential subsidence by establishing correlative horizons which were topographically level surfaces at the time of deposition. Correlation is accomplished by dividing the entire section into PACs at each locality, tracing individual PACs between pairs of localities and by correlating three major deepening events, distinguished at all localities by marked facies changes. Two PACs, one at the bottom of the sequence studied and one in the middle of the Keyser Formation aggraded to sea-level and were selected for subsidence analysis. The tops of each of these PACs once represented essentially horizontal synchronous surfaces. Difference in stratigraphic thickness between these surfaces can only be explained by differential subsidence. Differential subsidence (11·5 m in 60 km of distance) was progressively greater toward the south and was introduced into the stratigraphic record non-uniformly (more in some PACs than in others). Only by applying a model of small-scale episodic accumulation is it possible to recognize the synchronous palaeoisotopographic surfaces necessary for interpreting basin dynamics at this scale. In that PACs are predicted to occur in all facies affected by relative sea-level fluctuations, this method has potential for very detailed reconstruction of the patterns and amounts of differential subsidence in the stratigraphic record, especially in nearshore facies.
Single-cell DNA Methylome and 3D Multi-omic Atlas of the Adult Mouse Brain (2023)

Cytosine DNA methylation is essential in brain development and has been implicated in various neurological disorders. A comprehensive understanding of DNA methylation diversity across the entire brain in the context of the brain's 3D spatial organization is essential for building a complete molecular atlas of brain cell types and understanding their gene regulatory landscapes. To this end, we employed optimized single-nucleus methylome (snmC-seq3) and multi-omic (snm3C-seq<sup>1</sup>) sequencing technologies to generate 301,626 methylomes and 176,003 chromatin conformation/methylome joint profiles from 117 dissected regions throughout the adult mouse brain. Using iterative clustering and integrating with companion whole-brain transcriptome and chromatin accessibility datasets, we constructed a methylation-based cell type taxonomy that contains 4,673 cell groups and 261 cross-modality-annotated subclasses. We identified millions of differentially methylated regions (DMRs) across the genome, representing potential gene regulation elements. Notably, we observed spatial cytosine methylation patterns on both genes and regulatory elements in cell types within and across brain regions. Brain-wide multiplexed error-robust fluorescence in situ hybridization (MERFISH<sup>2</sup>) data validated the association of this spatial epigenetic diversity with transcription and allowed the mapping of the DNA methylation and topology information into anatomical structures more precisely than our dissections. Furthermore, multi-scale chromatin conformation diversities occur in important neuronal genes, highly associated with DNA methylation and transcription changes. Brain-wide cell type comparison allowed us to build a regulatory model for each gene, linking transcription factors, DMRs, chromatin contacts, and downstream genes to establish regulatory networks. Finally, intragenic DNA methylation and chromatin conformation patterns predicted alternative gene isoform expression observed in a companion whole-brain SMART-seq<sup>3</sup> dataset. Our study establishes the first brain-wide, single-cell resolution DNA methylome and 3D multi-omic atlas, providing an unparalleled resource for comprehending the mouse brain's cellular-spatial and regulatory genome diversity.
Body sway predicts romantic interest in speed dating (2020)

Social bonding is fundamental to human society, and romantic interest involves an important type of bonding. Speed dating research paradigms offer both high external validity and experimental control for studying romantic interest in real-world settings. While previous studies focused on the effect of social and personality factors on romantic interest, the role of non-verbal interaction has been little studied in initial romantic interest, despite being commonly viewed as a crucial factor. The present study investigated whether romantic interest can be predicted by non-verbal dyadic interactive body sway, and enhanced by movement-promoting ('groovy') background music. Participants' body sway trajectories were recorded during speed dating. Directional (predictive) body sway coupling, but not body sway similarity, predicted interest in a long-term relationship above and beyond rated physical attractiveness. In addition, presence of groovy background music promoted interest in meeting a dating partner again. Overall, we demonstrate that romantic interest is reflected by non-verbal body sway in dyads in a real-world dating setting. This novel approach could potentially be applied to investigate non-verbal aspects of social bonding in other dynamic interpersonal interactions such as between infants and parents and in non-verbal populations including those with communication disorders.
Multi‐target tracking in clutter using a high pulse repetition frequency radar (2015)

In this study, two algorithms of single‐target tracking in clutter using a high pulse repetition frequency radar are extended: the Gaussian mixture measurement likelihood‐integrated track splitting (GMM‐ITS) algorithm and the enhanced multiple models (MM) to multi‐target tracking algorithm, that is, the GMM‐joint ITS algorithm and the enhanced MM‐joint probabilistic data association algorithm, respectively. Both algorithms are extended on the basis of the optimal Bayes approach that creates track clusters for determining the nearby tracks that share measurements by enumerating and evaluating all the feasible joint measurement allocations. In all cases, the track trajectory probability density function is a Gaussian mixture, and both algorithms enable false track discrimination using the probability of target existence.
Performance Modeling of a Power Management/Control System. (2002)

This paper develops a performance model for a class of soft real time systems. The incentive came from a specific commercial system; however the resulting model can have other applications. The model incorporates a set of properties that are not all common in prior models such as a queueing network with a polled serving pattern, programmable priority levels, multiple message classes, network-load-dependent multiple service, and a subset of queues with direct feedback. The analytical model can estimate performance parameters for both the overall queuing network and its specific queues. The model can be used to aid design decisions at an early stage, and can be used for later system calibration and diagnosis. Both the performance model and a sample application are described.