gebhart/patrepeval huggingface dataset:
Analysis of redox states of protic and aprotic solutions irradiated by low linear energy transfer carbon-ion beams using a 2,2-diphenyl-1-picrylhydrazyl radical (2018)

The quantitative evaluation of changes in the redox state induced by low linear energy transfer (LET) radiations such as the plateau region of heavy-ion beams via formation of reactive oxygen species is of considerable importance to eliminate the adverse effects of radiation therapy on normal tissues adjacent to a tumour. In this study, a 2,2-diphenyl-1-picrylhydrazyl radical (DPPH˙) was used as a redox probe to estimate the redox states of protic and aprotic solutions irradiated by low LET carbon-ion (C-ion) beams. The dose dependence of the decrease in the absorption band due to DPPH˙ (which was solubilised by β-cyclodextrin (β-CD) in water) after irradiation with low LET C-ion beams (13 keV μm<sup>-1</sup>) was similar to that after X-irradiation. Similar results were obtained when H<sub>2</sub>O was replaced with methanol or acetonitrile although the slope values of the plots of the absorbance changes vs. radiation doses were twice larger as compared to the case in β-CD-containing H<sub>2</sub>O. Moreover, DPPH˙ was more susceptible to the C-ion beam than to X-rays in isopropyl myristate (IPM), which is one of the saturated fatty acid esters.
Hematopoietic stem cell transplantation for mitochondrial neurogastrointestinal encephalopathy: A single‐center experience underscoring the multiple factors involved in the prognosis (2021)

Allogenic HSCT could constitute a curative therapeutic option for carefully selected, young, presymptomatic, or mildly affected patients. Timing, donor selection, and optimal conditioning protocol are major determinants of outcome. HSCT is inadvisable in patients with advanced MNGIE disease.
Molecular Aspects Underlying the Vasodilator Action of Molsidomine (1989)

Using different techniques, we measured the kinetics of nitric oxide (NO) liberation from SIN-1, the metabolite of molsidomine, and some related sydnonimines like its thiomorpholinyl analog, compound C 78-0698, and compared it under identical experimental conditions with its biological action at the guanylate cyclase (GC) site, taking this target enzyme as a suitable bioassay. There was a close relationship between half-maximal activation of GC and the velocity of NO release. The thiomorpholinyl analog was slightly more active in NO liberation than SIN-1 and activated the enzyme more rapidly. The kinetics of SIN-1A and SIN-1C formation, determined by high-performance liquid chromatography, could be accurately described by a Bateman equation. Oxyhemoglobin shifted the concentration-response curve of SIN-1 at the isolated soluble GC concentration to the right, whereas methemoglobin was without any effect. The results of our chemical and biochemical studies suggest that velocity and amount of NO formation are the only rate-limiting factors of guanylate cyclase activation by sydnonimines like SIN-1. NO, therefore, exclusively is the mediator of their pharmacodynamic action. In remarkable contrast to nitrate esters like glyceryl trinitrate or isosorbide dinitrate, NO liberation is not dependent on the interaction with thiol-containing compounds like cysteine.
An Ultra-Low Power Subband-Based Electronic Stethoscope (2006)

Electronic stethoscopes are able to offer signal amplification and other benefits over traditional stethoscopes. However, many electronic stethoscopes rely on a personal computer for their signal processing, which reduces portability and requires a relatively large amount of power. This paper presents a low power, portable electronic stethoscope system that is based on a signal processing approach using an over-sampled filterbank. This system is implemented on an ultra-low resource DSP system. The stethoscope incorporates multiple filtering modes as well as audio record and playback (full and half speed) functionality.
Performance of W-CDMA mobile radio with turbo codes using prime interleaver (2002)

This paper evaluates the error rate performance of turbo codes with a new turbo internal interleaver called the prime interleaver (PIL) for turbo-coded W-CDMA mobile radio channel. Turbo coding with the PIL can generate codewords that have a good Hamming weight for a wide range of interleaving lengths (for example, 300-8000 bits) as required in multimedia communication services. Computer simulation results show that the turbo codes with the PIL, exhibit better performance than that with the conventional interleavers, and exhibit better performance than the concatenated coding of convolutional codes and Reed Solomon codes in frequency selective Rayleigh fading environments.
Effects of obesity on balance and gait alterations in young adults. (2012)

The effects of obesity on the balance and gait parameters like step width and foot angle (degree of toe out) in young adults were studied. 60 subjects of both the genders were taken. 30 were taken as a control group (non-obese, BMI < 25) and 30 were taken as experimental group (obese, BMI 30 >). Functional Reach Test (FRT) was used for Balance Testing and the Footprint method was used for Gait parameters measurements. The value of functional reach test in females was 11.90 +/- 0.12 inches in control group and 7.01 +/- 1.80 inches in experimental group (t = 5.31, P < 0.001) and in males, it was 16.45 +/- 0.72 inches in control and 11.66 +/- 0.53 inches in experimental group (t = 6.47, P < 0.001). The degree of toe out in females was 6.66 +/- 0.08 degrees for control and 8.13 +/- 0.21 degrees for experimental group (t = 4.08, P < 0.01) and in males, it was 6.59 +/- 0.04 for control and 9.79 +/- 0.51 for experimental group (t = 6.53, P < 0.001). The step width was found to be 4.41 +/- 0.15 inches (control group) and 6.27 +/- 0.35 inches (experimental) in males (t = 4.53, P < 0.01) and it was 3.95 +/- 0.03 inches (control) and 3.42 +/- 1.05 inches (experimental) in females (t = 0.77, P > 0.05). We concluded that obesity has a negative impact on balance of an individual. The degree of toe out was more in obese group as compared to normal BMI group in both genders. The Step Width measurement was more in males of obese group than that in males of normal BMI group but it showed statistically insignificant when compared in females of both groups.
The Cleave and Fill Tool: An All-Hexahedral Refinement Algorithm for Swept Meshes. (2000)

Sweeping algorithms provide the ability to generate all hexahedral meshes on a wide variety of three-dimensional bodies. The work presented here provides a method to refine these meshes by first defining a path through either the source or the target mesh and next by locating the sweeping layer to initiate the refinement. A major contribution of this work is the ability to automatically find a minimal distance path through the target or source mesh. The refinement is accomplished by using the pillowing procedure as proposed by Mitchell. [1] Keywords: mesh generation, hexahedral meshing, refinement, sweeping, 2 -D 3 samitch@sandia.gov 4 drwhite@sandia.gov 5 rjmeyer@sandia.gov Scott Mitchell, David White, and Ray Meyers work at Sandia National Laboratories, a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy under Contract DE-AC04-94AL8500. 1. INTRODUCTION Three-dimensional finite element analysis ...
Early detection of deep pressure ulcers (2007)

Deep pressure ulcers are hard to detect at an early stage because they start in deep tissue layers under intact skin. The aim of this project is to develop a pre-screening method to detect early skeletal muscle damage by measuring the rise of biomarkers present in blood or urine. For this it is necessary to know how tissue damage evolves over time, how this is reflected in a rise in levels of biochemical markers, and to understand the kinetics of this process.
122 Differential CD4 T cell subset depletion at mucosal sites in HIV infection (2009)

Acute HIV infection is characterized by massive loss of CD4 T cells from the gastrointestinal (GI) tract. Th17 cells are critical in the defense against microbes, particularly at mucosal surfaces. We analyzed Th17 cells in the blood, GI tract and broncheoalveolar lavage (BAL) of HIV-infected and uninfected humans, and SIV-infected and uninfected sooty mangabeys. We found that (i) human Th17 cells are specific for extracellular bacterial and fungal antigens, but not common viral antigens; (ii) Th17 cells are infected by HIV in vivo, but not preferentially so; (iii) CD4 T cells in blood of HIV-infected individuals are skewed away from a Th17 phenotype towards a Th1 phenotype with cellular maturation; (iv) there is significant loss of Th17 cells in the GI tract of HIV-infected individuals (v) Th17 cells are not preferentially lost from the BAL of HIV-infected individuals and (vi) SIV-infected sooty mangabeys maintain healthy frequencies of Th17 cells in the blood and GI tract. These observations further elucidate the immunodeficiency of HIV disease and may provide a mechanistic basis for the mucosal barrier breakdown that characterizes HIV infection. Finally, these data may help account for the non-progressive nature of non-pathogenic SIV infection in sooty mangabeys.
Computational Simulations of the Interaction of Lipid Membranes with DNA-Functionalized Gold Nanoparticles (2011)

We develop a shape-based coarse-grained (SBCG) model for DNA-functionalized gold nanoparticles (DNA-Au NPs) and use this to study the interaction of this potential antisense therapeutic with a lipid bilayer model of a cell membrane that is also represented using a coarse-grained model. Molecular dynamics simulations of the SBCG model of the DNA-Au NP show structural properties which coincide with our previous atomistic models of this system. The lipid membrane is composed of 30% negatively charged lipid (1,2-dioleoyl-sn-glycero-3-phosphoserine, DOPS) and 70% neutral lipid (1,2-dioleoyl-sn-glycero-3-phosphocholine, DOPC) in 0.15 M sodium chloride solution. Molecular dynamics (MD) simulations of the DNA-Au NP near to the lipid bilayer show that there is a higher density of DOPS than DOPC near to the DNA-Au NP since sodium counterions are able to have strong electrostatic interactions with DOPS and the DNA-Au NP at the same time. Using a steered MD simulation, we show that this counterion-mediated electrostatic interaction between DNA-Au NP and DOPS stabilizes the DNA-Au NP in direct contact with the lipid. This provides a model for interaction of DNA-Au NPs with cell membranes that does not require protein mediation.
Inheritance and chromosome location of Alp, a gene controlling aluminum tolerance in ‘Dayton’ barley (1997)

Abstract Aluminum (Al) toxicity is a major limiting factor in acid soils and more adequate genetic tolerance is needed to improve barley adaptation and production in affected regions. To study the inheritance and chromosome location of the Alp gene controlling Al tolerance in ‘Dayton’ barley the primary trisomics of sensitive ‘Shin Ebisu 16’ were crossed to ‘Dayton’. Parental, F 1 and F 2 seedlings were grown in nutrient solution containing 0.03, 0.06 and 0.09mM Al. and classified for tolerance by haematoxylin staining of the roots. In diploid F 2 progeny, Alp was inherited as a single gene, dominant at 0.06mM and recessive at 0.09 mM concentrations, as indicated by the 3:1 and 1:3 (tolerant: sensitive) segregation ratios, respectively. Segregation of the trisomic Frderived F 2 seedlings at 0.06mM Al deviated significantly from the 3:1 only for the triplo 4/‘Dayton’ cross. Data for this cross fit the expected trisomic ratios, indicating that the Alp gene is distally located from the centromere on chromosome 4. These results confirm that tolerance is simply inherited, but expression of tolerance is dependent on Al concentration and allele dose.
Dopant diffusion in C-doped Si and SiGe: physical model and experimental verification (2003)

We show that B and P exhibit suppressed, and As and Sb enhanced diffusion in C-rich Si. This can be well described by coupled diffusion of C and Si point defects. We present a physical model for the impact of C on dopant diffusion in Si and SiGe and demonstrate its reliability in the context of device characteristics of heterojunction bipolar transistors, which constitute a most sensitive tests for dopant diffusion on the nm scale.
Data from A Novel B7-H6–Targeted IgG-Like T Cell–Engaging Antibody for the Treatment of Gastrointestinal Tumors (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Advanced-stage gastrointestinal cancers represent a high unmet need requiring new effective therapies. We investigated the antitumor activity of a novel T cell–engaging antibody (B7-H6/CD3 ITE) targeting B7-H6, a tumor-associated antigen that is expressed in gastrointestinal tumors.&lt;/p&gt;Experimental Design:&lt;p&gt;Membrane proteomics and IHC analysis identified B7-H6 as a tumor-associated antigen in gastrointestinal tumor tissues with no to very little expression in normal tissues. The antitumor activity and mode of action of B7-H6/CD3 ITE was evaluated in &lt;i&gt;in vitro&lt;/i&gt; coculture assays, in humanized mouse tumor models, and in colorectal cancer precision cut tumor slice cultures.&lt;/p&gt;Results:&lt;p&gt;B7-H6 expression was detected in 98% of colorectal cancer, 77% of gastric cancer, and 63% of pancreatic cancer tissue samples. B7-H6/CD3 ITE-mediated redirection of T cells toward B7-H6–positive tumor cells resulted in B7-H6–dependent lysis of tumor cells, activation and proliferation of T cells, and cytokine secretion in &lt;i&gt;in vitro&lt;/i&gt; coculture assays, and infiltration of T cells into tumor tissues associated with tumor regression in &lt;i&gt;in vivo&lt;/i&gt; colorectal cancer models. In primary patient-derived colorectal cancer precision-cut tumor slice cultures, treatment with B7-H6/CD3 ITE elicited cytokine secretion by endogenous tumor-infiltrating immune cells. Combination with anti-PD-1 further enhanced the activity of the B7-H6/CD3 ITE.&lt;/p&gt;Conclusion:&lt;p&gt;These data highlight the potential of the B7-H6/CD3 ITE to induce T cell–redirected lysis of tumor cells and recruitment of T cells into noninflamed tumor tissues, leading to antitumor activity in &lt;i&gt;in vitro, in vivo&lt;/i&gt;, and human tumor slice cultures, which supports further evaluation in a clinical study.&lt;/p&gt;&lt;/div&gt;
Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome (2004)

Marfan syndrome is a connective tissue disorder caused by mutations in the gene encoding fibrillin-1 (FBN1). A dominant-negative mechanism has been inferred based upon dominant inheritance, mulitimerization of monomers to form microfibrils, and the dramatic paucity of matrix-incorporated fibrillin-1 seen in heterozygous patient samples. Yeast artificial chromosome-based transgenesis was used to overexpress a disease-associated mutant form of human fibrillin-1 (C1663R) on a normal mouse background. Remarkably, these mice failed to show any abnormalities of cellular or clinical phenotype despite regulated overexpression of mutant protein in relevant tissues and developmental stages and direct evidence that mouse and human fibrillin-1 interact with high efficiency. Immunostaining with a human-specific mAb provides what we believe to be the first demonstration that mutant fibrillin-1 can participate in productive microfibrillar assembly. Informatively, use of homologous recombination to generate mice heterozygous for a comparable missense mutation (C1039G) revealed impaired microfibrillar deposition, skeletal deformity, and progressive deterioration of aortic wall architecture, comparable to characteristics of the human condition. These data are consistent with a model that invokes haploinsufficiency for WT fibrillin-1, rather than production of mutant protein, as the primary determinant of failed microfibrillar assembly. In keeping with this model, introduction of a WT FBN1 transgene on a heterozygous C1039G background rescues aortic phenotype.
Recent Experience With Routine Patch Test Screening (1968)

Experience with patch test screening has been analyzed, and a modern patch test screening series presented. The screening series we find useful differs from most other recommended series in emphasizing medicaments and mixtures. While our experience deals only with patients from the western United States, the majority of conclusions should apply to patients elsewhere in North America. The proposed screening series is suggested as a step in the modernization of screening series so as to increase the clinically useful information extracted from routine patch testing. We find patch test screening valuable providing it is used to supplement, and not to supplant, patch testing with suspected environmental agents.
Navigating the landscape of nonlinear mechanical metamaterials for advanced programmability (2020)

We consider a flexible mechanical metamaterial comprising an elastomeric matrix with an embedded square array of circular holes. First, we use the deflated continuation technique of bifurcation analysis to explore its complex energy landscape, characterized by multiple bifurcations from which stable and unstable branches emanate. We then investigate how this landscape can be used to design materials with advanced programmability. We find that the response of the system can be constantly reprogrammed through local manipulation, moving it from one stable branch to another, and that small targeted imperfections can be harnessed to enhance such programmability.
Tunable band-reject filter and suppression of in-band interfering signals in mobile communication (2015)

For supporting a more efficient usage of available spectrum by mobile communication in unlicensed bands, a solution for robust and frequency agile receivers is proposed. Interfering signals of increased power level, expected in these bands, get acceptable as they are reduced by a tunable band-reject filter controlled by the digital receiver unit. The interfering signal position gets identified, the filter stopband gets moved on this position, and distortions of the wanted signal get compensated. A performance evaluation is done on a lab set-up based on hardware prototypes and on implemented control algorithms.
Active Guidance of Framework Development (1995)

. An app op iate combination of objecto iented p og amming concepts allows the development not only of single eusable components but also of semifinished a chitectu es (= f amewo ks).
Feature hashing for large scale multitask learning (2009)

Empirical evidence suggests that hashing is an effective strategy for dimensionality reduction and practical nonparametric estimation. In this paper we provide exponential tail bounds for feature hashing and show that the interaction between random subspaces is negligible with high probability. We demonstrate the feasibility of this approach with experimental results for a new use case --- multitask learning with hundreds of thousands of tasks.
CuInS2 Quantum Dot and Polydimethylsiloxane Nanocomposites for All‐Optical Ultrasound and Photoacoustic Imaging (Adv. Mater. Interfaces 20/2021) (2021)

Nanocomposites for Multimodality Optical Ultrasound and Photoacoustic Imaging In article number 2100518, Semyon Bodian, Richard J. Colchester, and co-workers develop a nanocomposite by integrating CuInS2 quantum dots within a polydimethylsiloxane matrix and deposited onto the distal end of an optical fiber. The wavelength-selective optical absorption enables co-registered all-optical ultrasound and photoacoustic imaging, using absorbed laser light for ultrasound generation and transmission of photoacoustic excitation light. This nanocomposite will enable molecular and microstructural clinical imaging particularly intravascular imaging. Figure design: Amy Warnock.
Maximum Virtual Inertia From DC-Link Capacitors Considering System Stability at Voltage Control Timescale (2021)

In power electronics-dominant systems (PEDSs), the declining-inertia issue is one of the most significant challenges to tackle. The inertia emulation from DC-link capacitors is one cost-effective and application-friendly solution to enhance the system inertia. Although the virtual inertia control of the DC-link capacitor supports the grid frequency with a relatively long-term effect, it affects the dynamic of the power converter at multiple timescales. In turn, the maximum effective virtual inertia from the DC-link capacitor is limited by the operation condition of the converter. Thus, to properly design the virtual inertia control, the dynamics of the faster timescale than the inertia emulation should be addressed. With the above, this article analyzes the maximum virtual inertia of DC-link capacitors based on a multi-timescale model of power converters. First, the system stability considering virtual inertia control of DC-link capacitors is analyzed in the submodel at the voltage control timescale (VCT), where the virtual inertia control parameters are accordingly tuned on a pre-designed converter. Then, the maximum effective virtual inertia is identified in the submodel at the rotor motion timescale (RMT). The exploration and findings in this article are beneficial to the power converter design and future inertia placement optimization in PEDSs. Case studies on a hardware-in-the-loop platform are conducted to validate the proposed model and the analysis method.
Computional modeling of University budget and finance (2013)

The discrete time mathematical model describing fundamental processes of the university, i.e. interdynamics among students, lectures and finances is presented. The model consists of three differential equations.
The Biochemistry and Genetics of Microbial Perchlorate Reduction (2006)

The identification and analysis of the genes encoding perchlorate reductase and chlorite dismutase has provided not only a building block for pathway understanding, but has also provided a tool for bioremediative and phylogenetic studies. On-going genome sequencing will further facilitate transcriptional profiling under perchlorate-reducing conditions via microarray analyses. This analysis will give a more inclusive look into transcriptional expression patterns associated with the perchlorate metabolism. While further advancements in the genetic analysis of perchlorate-reducing bacteria continue, the recent development of a genetic system in D. aromatica will provide an invaluable tool for corroborating microarray results and solidifying hypotheses regarding microbial perchlorate metabolism.
Role of hydroxypropyl-&beta;-cyclodextrin on freeze-dried and gamma-irradiated PLGA and PLGA&ndash;PEG diblock copolymer nanospheres for ophthalmic flurbiprofen delivery (2012)

Poly(D,L-lactide-co-glycolide) and poly(D,L-lactide-co-glycolide) with poly(ethylene glycol) nanospheres (NSs) incorporating flurbiprofen (FB) were freeze-dried with several cryoprotective agents and sterilized by γ-irradiation. Only when 5.0% (w/v) hydroxypropyl-β-cyclodextrin (HPβCD) was used, a complete resuspension by manual shaking and almost identical particle size of the NSs was obtained after freeze-drying. In vitro drug release and ex vivo corneal permeation of NSs with and without HPβCD were evaluated. The presence of HPβCD resulted in a reduction of burst effect, providing a more sustained release of the drug. A significant decrease in the FB transcorneal permeation of NSs containing HPβCD was obtained, related to the slower diffusion of FB observed in the in vitro results. The uptake mechanism of the NSs was examined by confocal microscopy, suggesting that NSs penetrate corneal epithelium through a transcellular pathway. Ocular tolerance was assessed in vitro and in vivo by the Eytex™ and Draize test, respectively. Long-term stability studies revealed that γ-irradiated NSs stored as freeze-dried powders maintained their initial characteristics. Stability studies of the resuspended NSs after 3 months of storage in the aqueous form showed that NSs were stable at 4°C, while formulations stored at 25°C and 40°C increased their initial particle size.