gebhart/patrepeval huggingface dataset:
ASS steigert die Expression von EGFR in Magenkarziomzellen und verbessert ihr Ansprechen auf Iressa, einem Hemmstoff der EGFR Tyrosinkinase (2015)

Hintergrund/Einleitung: Rezeptor-Tyrosinkinasen spielen bei der Regulation des Zellwachstums und der Pathogenese maligner Erkrankungen eine bedeutende Rolle. Die Blockade dieser Rezeptoren durch spezifische Antikörper als Form einer Tumortherapie findet für die her2/neu (erbB2) Kinase bereits Anwendung; jedoch existieren mehrere Rezeptoren der EGFR-Familie nebeneinander. Die gezielte Hochregulierung eines Rezeptorsubtypes und dessen anschließende Blockade sollte das Ansprechen maligner Tumoren auf diese Therapieform verbessern.
POSTER: Anomaly-based misbehaviour detection in connected car backends (2016)

As a novel way to protect connected cars, we are developing a Security Information and Event Management System (SIEM) called Security Management of Services in Connected Cars (SeMaCoCa) located in the backend of the connected car. For that we defined a connected car architecture and possible use cases which serve as a basis for the research. Using data from the connected cars and additional information, attacks on individual vehicles or fleets should be recognized. A combination of rule-based-, machine-learning-, deep learning-, real-time-based-, security-algorithms and algorithms for big data are used. Furthermore, we aim for a privacy-friendly solution that does not require the backend operator to have access to cleartext data. The new security system should be able to recognise misbehaviour under the conditions of a permanently growing number and variety of connected cars, upcoming services on the market and related constantly to changing user behavior. The challenge for the security system is, that under these conditions no stable system state exists, that the system can rely on. In this paper, we introduce the architecture of SeMaCoCa, user stories and the idea behind the approach of the system.
Internet Streaming SIMD Extensions (1999)

Because floating-point computation is the heart of 3D geometry, speeding up floating-point computation is vital to overall 3D performance. To produce a visually perceptible difference in graphics applications, Intel's 32-bit processors-based on the IA-32 architecture-required an increase of 1.5 to 2 times the native floating-point performance. One path to better performance involves studying how the system uses data. Today's 3D applications can execute a lot faster by differentiating between data used repeatedly and streaming data-data used only once and then discarded. The Pentium III's new floating-point extension lets programmers designate data as streaming and provides instructions that handle this data efficiently. The authors designed the Internet Streaming SIMD Extensions (ISSE) to enable a new level of visual computing on the volume PC platform. They discuss their results in terms of boosting the performance of 3D and video applications.
A COMPARISON OF THE EFFECTS OF SEVERAL ANTIMITOTIC AGENTS (1954)

A COMPARISON OF THE EFFECTS OF SEVERAL ANTIMITOTIC AGENTS Get access C. C. BOWEN, C. C. BOWEN Search for other works by this author on: Oxford Academic PubMed Google Scholar G. B. WILSON G. B. WILSON Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Heredity, Volume 45, Issue 1, January 1954, Pages 3–9, https://doi.org/10.1093/oxfordjournals.jhered.a106431 Published: 01 January 1954 Article history Received: 13 August 1953 Published: 01 January 1954
A Photonic 1 × 4 Power Splitter Based on Multimode Interference in Silicon–Gallium-Nitride Slot Waveguide Structures (2016)

In this paper, a design for a 1 × 4 optical power splitter based on the multimode interference (MMI) coupler in a silicon (Si)-gallium nitride (GaN) slot waveguide structure is presented-to our knowledge, for the first time. Si and GaN were found as suitable materials for the slot waveguide structure. Numerical optimizations were carried out on the device parameters using the full vectorial-beam propagation method (FV-BPM). Simulation results show that the proposed device can be useful to divide optical signal energy uniformly in the C-band range (1530-1565 nm) into four output ports with low insertion losses (0.07 dB).
Focused Abbreviated Survey MRI Protocols for Brain and Spine Imaging (2023)

There has been extensive growth in both the technical development and the clinical applications of MRI, establishing this modality as one of the most powerful diagnostic imaging tools. However, long examination and image interpretation times still limit the application of MRI, especially in emergent clinical settings. Rapid and abbreviated MRI protocols have been developed as alternatives to standard MRI, with reduced imaging times, and in some cases limited numbers of sequences, to more efficiently answer specific clinical questions. A group of rapid MRI protocols used at the authors' institution, referred to as FAST (focused abbreviated survey techniques), are designed to include or exclude emergent or urgent conditions or screen for specific entities. These FAST protocols provide adequate diagnostic image quality with use of accelerated approaches to produce imaging studies faster than traditional methods. FAST protocols have become critical diagnostic screening tools at the authors' institution, allowing confident and efficient confirmation or exclusion of actionable findings. The techniques commonly used to reduce imaging times, the imaging protocols used at the authors' institution, and future directions in FAST imaging are reviewed to provide a practical and comprehensive overview of FAST MRI for practicing neuroradiologists. <sup>©</sup>RSNA, 2023 Quiz questions for this article are available in the supplemental material.
Accurate MR Image Registration to Anatomical Reference Space for Diffuse Glioma (2020)

To summarize the distribution of glioma location within a patient population, registration of individual MR images to anatomical reference space is required. In this study, we quantified the accuracy of MR image registration to anatomical reference space with linear and non-linear transformations using estimated tumor targets of glioblastoma and lower-grade glioma, and anatomical landmarks at pre- and post-operative time-points using six commonly used registration packages (FSL, SPM5, DARTEL, ANTs, Elastix, and NiftyReg). Routine clinical pre- and post-operative, post-contrast T1-weighted images of 20 patients with glioblastoma and 20 with lower-grade glioma were collected. The 2009a Montreal Neurological Institute brain template was used as anatomical reference space. Tumors were manually segmented in the patient space and corresponding healthy tissue was delineated as a target volume in the anatomical reference space. Accuracy of the tumor alignment was quantified using the Dice score and the Hausdorff distance. To measure the accuracy of general brain alignment, anatomical landmarks were placed in patient and in anatomical reference space, and the landmark distance after registration was quantified. Lower-grade gliomas were registered more accurately than glioblastoma. Registration accuracy for pre- and post-operative MR images did not differ. SPM5 and DARTEL registered tumors most accurate, and FSL least accurate. Non-linear transformations resulted in more accurate general brain alignment than linear transformations, but tumor alignment was similar between linear and non-linear transformation. We conclude that linear transformation suffices to summarize glioma locations in anatomical reference space.
Evaluation of a Mobile Application for Multimodal Land Navigation (2013)

Among many of their countless dismounted roles, U.S. Air Force Battleﬁeld Airmen must navigate in unfamiliar environments with many potential threats while performing their mission objectives. The eﬀectiveness of navigating with a map and compass is compromised in reduced visibility conditions, such as in fog or during nighttime operations. Moreover, focusing on a map draws attention away from the immediate surroundings and reduces their ability to detect threats. To ameliorate this problem, we prototyped auditory and tactile navigation displays controlled only by a mobile phone using its built-in GPS and compass. The auditory and tactile displays direct users towards their destination with 3D audio and vibrotactile cues, respectively. We evaluated the navigation displays on a waypoint navigation task. Results suggest that auditory and tactile displays can guide users to their destination as eﬀectively as a visual display (i.e., a GPS enabled map). Initial ﬁndings justify further development of multimodal navigation displays to increase the eﬃciency of Battleﬁeld Airmen in land navigation tasks.
Highly Energetic Tetraazidoborate Anion and Boron Triazide Adducts (2001)

The first crystal structures of the highly energetic tetraazidoborate anion and boron triazide adducts with quinoline and pyrazine as well as of tetramethylpiperidinium azide have been determined. Synthesis procedures and thorough characterization by spectroscopic methods of these hazardous materials are given. Quantum chemical calculations were carried out for B(N(3))(4)(-), B(N(3))(3), C(5)H(5)N.B(N(3))(3), (N(3))(3)B.NC(4)H(4)N.B(N(3))(3), and the hypothetical C(3)H(3)N(3).[B(N(3))(3)](3) at HF, MP2, and B3-LYP levels of theory. The structure of tetraazidoborate was optimized to S(4) symmetry and confirmed the results obtained from the X-ray diffraction analysis. The dissociation enthalpies for the pyridine (model for quinoline) as well as for the pyrazine adduct were calculated. For pyridine-boron triazide a value of 10.0 kcal mol(-1) (for pyrazine-bis(boron triazide) an average of 2.35 kcal mol(-1) per BN unit) was obtained.
Script Classification and Writer Identification: Two Tasks for a Common Understanding of Cultural Heritage - Dataset (2021)

Writer identification and Script classification are usually considered as two separated and very different tasks, as well in palaeography as in computer science. Following the ICDAR competition on the CLAMM corpus about script classification and dating, this dataset provides the output created by running two infrastructures created for Script classification at a large scale (medieval scripts) on a more homogeneous dataset with a focus on Writer Identification. If you use the present repository, its data and figures, please consult and cite: Stutzmann, Dominique, Christopher Tensmeyer, and Vincent Christlein. « Writer Identification and Script Classification: Two Tasks for a Common Understanding of Cultural Heritage ». manuscript cultures, 15 (2020): 11-24. https://www.csmc.uni-hamburg.de/publications/mc/files/articles/mc15-02-stutzmann.pdf
Blastocystis subtype distribution in domestic and captive wild bird species from Brazil using next generation amplicon sequencing (2020)

<i>Blastocystis</i> is a food and water borne intestinal parasite commonly identified in humans and many other animals worldwide. Of the nine potentially zoonotic subtypes of <i>Blastocystis</i>, seven have been reported in bird species. However molecular studies of <i>Blastocystis</i> subtype diversity in birds are limited. In this study, fecal samples from 109 domestic and captive wild birds from Minas Gerais, Brazil were tested for the presence of <i>Blastocystis</i> subtypes using PCR and next generation amplicon sequencing of a fragment of the small subunit ribosomal RNA (SSU rRNA) gene. Birds from 11 orders and 38 species from both local markets and bird conservation facilities were sampled. <i>Blastocystis</i> was present in 14.7% of samples, and eight subtypes, six previously reported (ST5, ST6, ST7, ST10, ST14, ST24) and two novel subtypes (named ST27 and ST28), were identified. The most commonly identified subtypes were ST7 and ST6 identified in 10 (62.5%) and 6 (37.5%) of 16 <i>Blastocystis</i> positive samples. At least one of the three zoonotic subtypes identified (ST5, ST6, and ST7) was found in 81.3% of <i>Blastocystis</i> positive samples. Infection with multiple <i>Blastocystis</i> subtypes was common and identified in 62.5% of positive samples. This study is the first to use next generation amplicon sequencing to characterize <i>Blastocystis</i> subtype diversity in birds. The findings presented here confirm that birds may serve as reservoirs of zoonotic subtypes of <i>Blastocystis</i> and that the role of birds in transmission of <i>Blastocystis</i> to humans requires further study.
Mesenchymal Stem Cells and Cancer — for Better or for Worse? (2008)

The importance of the microenvironment and stroma in the evolution and progression of solid tumors has re-emerged in the past few years. Recently, mesenchymal stem cells (MSCs), which are the progenitors of stromal cells and fibroblasts, have also been found to interact with cancer cells. Most commonly isolated from the bone marrow, MSCs are multipotent adult stem cells with immunomodulatory effects and the ability to home to sites of injury. These properties, clearly useful for therapeutic purposes, have recently been found to be abused by cancer cells for their own end. However, reports also show that MSCs can inhibit tumor growth under certain circumstances. This review briefly describes what is currently known about this emerging field of cancer-MSC biology, which is bringing new knowledge to an old disease and may hopefully reveal new ideas and targets for treatment.
Behavioural mechanisms underlying functional response of sea stars Asterias vulgaris preying on juvenile sea scallops Placopecten magellanicus (2021)

The functional response characterises the relationship between prey density and the consumption rate of individual predators. Typically, it is studied by fitting a model to observations of predation rate at different prey densities. The behavioural mechanisms underlying a functional response are not well understood, and estimates of model parameters seldom conform to observations of behaviour. We have developed a mechanistic approach that directly incorporates behavioural observations into characterisation of the functional response. Laboratory experiments were used to record predation rates and observe foraging behaviour of sea stars Asterias vulgaris preying on juvenile sea scallops Placopecten magellanicus at different densities. Experiments were conducted in tanks with no sediment and tanks with sediment. Behavioural data from the experiments were used to calculate parameters of functional response models Th (handling time per prey) and a (rate of successful search). On both substrates, Th remained constant across prey density, while a was density-dependent. An inverse quadratic was used to describe a and was incorporated into a functional response model. Estimates of a were also obtained by fitting the functional response model to the predation rate data using regression analysis. These estimates of a were highly consistent with the estimates calculated from behavioural data. On both substrates, sea stars preying on scallops had a Type III sigmoid-shaped functional response; on sediment, predation rate decreased at high prey densities. Sea star ability to capture attacked prey was probably the mechanism underlying the observed responses. In general, behavioural information can lead to better understanding of observed functional responses. © Inter-Research 2006.
Synthesis and Structure of a New Lithium Amide Ligand Precursor:  A Tridentate Nitrogen-Based Donor Set of the Formula N(SiMe2CH2NMe2)2. Synthesis and Structure of the Group 4 Amides MCl3[N(SiMe2CH2NMe2)2] (M = Ti, Zr, Hf) (1997)

The new lithium amide LiN(SiMe(2)CH(2)NMe(2))(2) was prepared by reaction of NH(3) with the corresponding silylamine Me(2)NSiMe(2)CH(2)NMe(2) followed by addition of butyllithium. This lithium derivative exists as a dimer in the solid state wherein the two lithium ions are bridged by the two amido units with the amine arms of each unit bonded to opposite lithium centers in an overall pseudo D(2) structure; however, in solution, a fluxional process serves to interconvert the enantiomeric forms of the dimer unit. The coordination chemistry of the lithium amide dimer has been investigated; reaction with a series of group 4 starting halides, MCl(4), leads to the corresponding complexes MCl(3)[N(SiMe(2)CH(2)NMe(2))(2)], where M = Ti, Zr, and Hf. The structures of these starting trihalides in solution and in the solid state are presented.
2A2-K05 Synthesizing method of Friction Sensation using Vibration : The Relationship between Cutaneously Perceived Friction and Stick-Slip Vibration (2009)

The relationship between cutaneous sensation of friction and skin dynamic deformation is not investigated enough. We conducted observations of stick-slip phenomena using a high-speed camera for representing friction sensation, which could be delivered by the proposed vibratory stimulation method. We confirmed the relationships of stick-slip vibration frequencies with normal forces and hand velocities. We also confirmed the relationships of normal force with kinematic friction coefficients and the spring coefficient of the stick-slip model. The parameters of the stick-slip model were identified based on the observations. Finally, friction display using vibratory stimulation based on the identified stick-slip model showed improvements in representing realistic friction sensation.
Proactive control of group revision assistance management using p2p technology (2005)

This paper describes the prototype and evaluations of the GRAM (group revision assistance management), a peer-to-peer (P2P) and a proactive mechanism based revision management system. GRAM enables the software developer to exercise proactive version control of a development project, thus preventing serious problems from being caused by other systems. GRAM performs revision collision prevention and software source code synchronization in a potential overlay network of peers connected via the Internet/LAN/WAN. This system provides four special features in comparison with other version management systems: (1) higher system reliability and robustness; (2) effective revision collision prevention using proactive agents; (3) context-aware environment for team software revision; and (4) unified XML format for configurations and history files as well as system and agent exchange messages. Each peer of GRAM system has a unique identifier using the JXTA framework, and holds two spaces: a shared space synchronized with other peers and a workspace for the user's ordinary editing. Experimental results obtained with a prototype implementation on an enumerated network confirm GRAM's efficiency.
1730. Real-World Use Of Dalbavancin In A US Tertiary Referral Center (2022)

Abstract Background Dalbavancin is a lipoglycopeptide with prolonged half-life currently approved for treatment of bacterial skin and soft tissue infections. Off-label uses of dalbavancin include multiple Gram-positive infections requiring long-term antibiotics use. However, clinical data regarding Dalbavancin use in the real-world setting remains limited. Methods We conducted a retrospective cohort study of all adult inpatients who were administered ≥1 dose of Dalbavancin between November 2017 and March 2022. Results Forty-nine adults were identified. Dalbavancin was used to treat skin/soft tissue infections in 9 patients (18.8%). Off-label uses accommodated for the majority of patients, with diagnoses included: bloodstream infection (24, 50%), osteomyelitis (9,18.8%), native valve infective endocarditis (6,12.5%), native septic arthritis (6,12.5%), epidural abscess (4,8.3%), catheter-related bacteremia (3,6.3%) prosthetic joint infection (3,6.3%), and diabetic foot infection (1,2.1%). No patients with prosthetic valve infective endocarditis were identified. Staphylococcus aureus was the most common treated pathogen: MRSA (15, 35.7%), MSSA (17, 40.5%). Other pathogens included: Streptococcus (2,4.8%), Enterococcus (4,9.5%), coagulase negative Staphylococcus (5,11.9%), other gram positive (4,9.5%), none (2,4.8%). Among patients who completed therapy, overall cure, and clinical response as assessed at day 42 was achieved in 29 (96.7%) of patients,1 patient (3.3%) had relapse due to noncompliance with antimicrobial suppressive regimen. Intravenous drug use was the most common cause among patients who did not complete treatment (10, 58.8%). Adverse events included mild elevation in liver function tests, which were reversible and were not definitively related to the treatment. No rashes or infusion related reaction were reported. There were no adverse events resulting in drug discontinuation. Conclusion Real-world, including off-label, use of Dalbavancin appears safe and is associated with favorable treatment responses. Therefore, it should be considered as an alternative treatment approach in certain patient population including at risk population that may otherwise discharge from the hospital with no antimicrobial treatment or suboptimal oral antibiotics. Disclosures All Authors: No reported disclosures.
A Mechanistic Model of Top-of-the-Line Corrosion (2007)

A mechanistic model is developed to predict the general corrosion rate at the top of a gas pipeline. This model covers the three main processes involved in the top-of-the-line corrosion (TLC) phenomena: the dropwise condensation, the behavior of the chemistry in the condensed water, and the corrosion at the steel surface. The dropwise condensation process is modeled based on the heat and mass-transfer theory and is used to predict the condensation rate. The breakdown of species concentrations in the droplet is established through the main thermodynamic and chemical equilibrium. The general corrosion rate is predicted using the kinetics of the electrochemical reactions at the steel surface and by taking into account the mass-transfer and chemical reactions occurring inside the droplet. Finally, the accuracy of the predictions of the model is evaluated by comparison with experimental data.
Lupus low disease activity state attainment in the phase 3 TULIP trials of anifrolumab in active systemic lupus erythematosus (2023)

NCT02446912 and NCT02446899.
Molecular and particulate depositions for regional myocardial flows in sheep. (1990)

The deposition of microspheres in small tissue regions is not strictly flow dependent. In comparison with the soluble flow marker 2-iododesmethylimipramine (IDMI), deposition of 16.5-microns microspheres was mildly but systematically biased into high flow regions of rabbit hearts (Bassingthwaighte JB, Malone MA, Moffett T-C, King RB, Little SE, Link JM, Krohn KA. Am J Physiol 1987;253 (Heart Circ Physiol 22):H184-H193). To examine the possibility of bias in larger hearts, a similar study was undertaken in sheep. 141Ce- and 103Ru-labeled 16.5-microns microspheres in one syringe and 125I- and 131I-DMI in another syringe were injected simultaneously into the left atrium of five open-chest sheep while obtaining reference blood samples from the femoral artery. In six other sheep, one microsphere type and one IDMI were used. Hearts were removed 1 minute after injection, cut into approximately 254 pieces averaging 217 mg, and regional deposition densities calculated for each tracer from the isotopic counts. Correlations in the five animals between the two differently labeled IDMIs and between the two microspheres were both greater than or equal to 0.98. In all 11 sheep, scatter plots of microsphere deposition densities versus IDMI densities showed that differences between microspheres and IDMI had substantially more scatter (0.84 less than r less than 0.98) but were not random. Microsphere depositions tended to be lower than IDMI depositions in low flow regions and higher in high flow regions, in accord with the expected bias that at a bifurcation a microsphere is most likely to enter the branch with higher flow. There was less bias ascribable to endomyocardial/epicardial maldistribution. Thus, while microsphere depositions appear to err systematically with respect to flow when the regions of interest are small enough that the diameters of their arterioles are only a few times those of the microspheres, microspheres are, in sheep as in rabbits, adequate for estimating regional flows.