gebhart/patrepeval huggingface dataset:
Figure S2 from Clonotypic Diversification of Intratumoral T Cells Following Sipuleucel-T Treatment in Prostate Cancer Subjects (2023)

&lt;p&gt;Supplementary Figure S2 - Assessments of unique TCR sequences in the blood for healthy donors and for sipuleucel-T-treated subjects were performed on PBMCs taken before the preparation of each sipuleucel-T-treatment. A, TCR sequence profiles in healthy donors and sipuleucel-T-treated subjects with prostate cancer over time. Sipuleucel-T-treated subjects had a significantly higher mean number of productive TCR sequences at baseline (Week 0) compared with Week 2 and Week 4 (P &lt; 0.01, paired t-test on the log scale). No differences in mean productive sequences in healthy donors over time were detected (NS (not significant), paired t-test on the log scale). The number of unique sequences was higher in sipuleucel-T-treated subjects at Week 0 and Week 2 compared with healthy donors (Wilcoxon one-sided test, P = 0.025 and 0.053, respectively). B, Shannon diversity index for TCR repertoire in blood from healthy donors and sipuleucel-T-treated subjects with prostate cancer. The median Shannon diversity index of healthy donors and a sipuleucel-T-treated subject at baseline (Week 0) and Weeks 2 and 4 is shown. TCR sequence diversity was higher in sipuleucel-T-treated subjects compared with healthy donors. Shannon diversity index decreased at Weeks 2 and 4 compared with baseline in sipuleucel-T-treated subjects (P &lt; 0.001), whereas Shannon diversity index remained stable over time in healthy donors.&lt;/p&gt;
A hybrid boost modular multilevel converter-based bipolar high voltage pulse generator (2017)

Conventional Modular Multilevel Converter (MMC) with Half-Bridge Sub-Modules (HB-SMs) can be used effectively as a solid-state high-voltage pulse generator to chop a high-voltage dc input into a bipolar pulsed output voltage without employing neither high-voltage semiconductor switches nor series-connected switches. Nonetheless, its boosting capability is constrained. In this paper, a hybrid boost MMC-based bipolar high-voltage pulse generator is proposed where each arm contains a combination of Full-Bridge SMs (FB-SMs) and HB-SMs. The HB-SMs and FB-SMs have the same rated voltage. The proposed approach is able to generate bipolar pulses, and operates with a wide range of boosting capability. Detailed illustration of the proposed configuration and its operational concept are presented. Simulation models for the proposed approach are built, for different FB-SMs to HB-SMs ratios, using Matlab/Simulink platform. Experimental results for a scaled-down prototype are presented to validate the concept.
Wettability Alteration during Low-Salinity Waterflooding in Carbonate Reservoir Cores (2014)

Abstract Production enhancement by low-salinity waterflood in carbonate formations is a subject of intense speculation. Several mechanisms are attributed to enhanced oil recovery by low-salinity waterflooding in carbonate formations. Review of experimental data in the literature indicates that the main mechanism involves interaction of Na+, Cl−, Ca2+, Mg2+, SO42− and crude oil carboxylate ions (R-COO−) with the rock in the electrical double layer (EDL) near the surface of carbonate pores, leading to wettability alteration. In this study, we performed four seawater floods in heterogeneous low-permeability carbonate cores followed by low-salinity floods. The core permeability is between 0.5 to 1.5 md, and porosity in the range of 18 to 25%. Cores were aged for eight weeks at reservoir pressure and temperature. We also conducted pendant drop oil-brine IFT measurement, and captive oil-droplet contact angle at different brine salinity, with and without the presence of surfactant. The carbonate core flood results show that removing NaCl from seawater or diluting the seawater twice and four times yielded about 8% incremental oil. In one experiment, the change in the effluent ionic concentrations was measured, and it was observed a decrease in Ca2+, Mg2+, Cl−, and SO42−. Using pendant drop IFT measurements, oil-brine IFT increased with decreasing salinity both in presence and in absence of 1,000-ppm surfactant. From captive oil-droplet contact-angle measurements, it was observed that cleaned un-aged carbonate core slabs were water-wet, and became more water-wet as salinity decreased (both in presence and in absence of 1000-ppm surfactant). The wettability of crude-aged carbonate core slabs altered from oil-wet to intermediate-wet as salinity decreased. And, the wettability changed from intermediate-wet to water-wet with decreasing salinity in presence of 1,000-ppm surfactant. Moreover, addition of small amount of surfactant alters the wettability of crude-aged or cleaned un-aged carbonate core slabs towards water-wet. The degree of water-wetness achieved by surfactant solution depends on salinity level.
V950 SELECTIVE RENAL PARENCHYMAL CLAMPING IN ROBOTIC PARTIAL NEPHRECTOMY: INITIAL EXPERIENCE (2010)

You have accessJournal of UrologyLaparoscopic Partial Nx and Single Port Surgery1 Apr 2010V950 SELECTIVE RENAL PARENCHYMAL CLAMPING IN ROBOTIC PARTIAL NEPHRECTOMY: INITIAL EXPERIENCE Davis P. Viprakasit, Hernan O. Altamar, Nicole L. Miller, and S. Duke Herrell Davis P. ViprakasitDavis P. Viprakasit More articles by this author , Hernan O. AltamarHernan O. Altamar More articles by this author , Nicole L. MillerNicole L. Miller More articles by this author , and S. Duke HerrellS. Duke Herrell More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1855AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The creation of a bloodless field during minimally invasive approaches to nephron-sparing surgery often requires complete warm ischemia with renal hilar clamping that can potentially result in subsequent renal damage. We describe our early experience using a laparoscopic clamp to induce selective regional ischemia during robotic-assisted partial nephrectomy without hilar occlusion. METHODS Following transperitoneal renal mobilization and delineation of the renal tumor margin using laparoscopic ultrasound, the laparoscopic clamp is placed across the renal parenchyma 2 to 3-cm proximal to the resection line. After tumor excision, the renal defect is repaired robotically and hemostatic agents are used to aid in achieving compressive hemostasis. RESULTS Three patients with predominantly exophytic renal masses underwent this procedure for elective indications. Mean tumor diameter was 4.9 cm (range 1.2-7.0). Mean selective clamp time was 37 minutes (range 20-52). Estimated blood loss was minimal and no patients required renal hilar clamping. There were no peri-operative complications. Mean change in preoperative and postoperative creatinine was 0.1 (±0.09). Final pathology revealed clear cell and papillary renal carcinomas with no positive margins on frozen or final evaluation. CONCLUSIONS Regional renal parenchymal clamping during robotic partial nephrectomy can be safely and effectively used to create a bloodless operative field in select patients with optimally located renal tumors. Our early experience with this technique allows for frozen pathologic evaluation of the tumor and margin status without concern for warm ischemia and represents another tool for surgeons performing minimally-invasive nephron-sparing surgery. Nashville, TN© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e370 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Davis P. Viprakasit More articles by this author Hernan O. Altamar More articles by this author Nicole L. Miller More articles by this author S. Duke Herrell More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Synthesis of Tungsten Nitrene Complexes as Precursors to Tungsten Nitride. (1995)

Chemical vapor deposition using organometallic precursors (MOCVD) provides a method for the preparation of thin films. Low valent tungsten nitrene complexes were synthesized as potential precursors to tungsten nitride (WN(x)), a material used in diffusion barriers for Si or GaAs semiconductor devices. The original target precursors for MOCVD of WN(x) were the carbonyl-containing complexes (CO)(5-n)(PR3)(n)W-NR, where R is an alkyl or aryl group. Later synthetic work involved the tungsten (IV) imido (or nitrene) complexes (CO) 2I2LW(triple bonds)NPh, which were prepared by oxidation of the zwitterionic species (CO)5WNPhNPhC(OMe)Ph with one equivalent of I2 followed by addition of a the coordinating species L L=THF, pyridine, PMe3, P(OMe)3.
Microbial diversity in various types of paper mill sludge: identification of enzyme activities with potential industrial applications (2016)

This study is the first comprehensive investigation of enzyme-producing bacteria isolated from four sludge samples (primary, secondary, press and machine) collected in a Kraft paper mill. Overall, 41 strains encompassing 11 different genera were identified by 16S rRNA gene analysis and biochemical testing. Both biodiversity and enzymatic activities were correlated with sludge composition. Press sludge hosted the largest variety of bacterial strains and enzymatic activities, which included hydrolytic enzymes and ligninolytic enzymes. In contrast, strains isolated from secondary sludge were devoid of several enzymatic activities. Most strains were found to metabolize Kraft liquor at its alkaline pH and to decolorize industrial lignin-mimicking dyes. Resistance to lignin or the ability to metabolize this substrate is a prerequisite to survival in any paper mill sludge type. We demonstrate here that the bacterial strains found in a typical Kraft paper mill represent a source of potential novel enzymes for both industrial applications and bioremediation.
Toward Parsimony in Shoreline Change Prediction (I): Basis Function Methods (2009)

Single-transect methods of shoreline change prediction are unparsimonious, i.e., they tend to overfit data by using more parameters than necessary because they assume that both signal and noise at adjacent transects are independent. Here we introduce some new methods that reduce overfitting by expressing change rate as a linear sum of basis functions. In the method of IC-binning, the basis functions are boxcars—an information criterion is used to assign contiguous alongshore locations into bins within which change rate is constant; the resulting rate is discontinuous but may be useful for beach management. In the polynomial method, the basis functions are polynomials in alongshore distance, and the change rate varies continuously along the beach. In the eigenbeaches method, the basis functions are the principal components of the matrix of shorelines. To choose the number of basis functions in each method, and to compare methods with each other, we use an information criterion. We apply these new methods to shoreline change on Maui Island, Hawaii, briefly here, and in more detail in a companion paper. The polynomial method works best for short beaches with rates that vary slowly in the alongshore direction while eigenbeaches works best for shorelines that are long, or have rates that vary rapidly in the alongshore direction. The Schwarz information criterion and the AICu version of the Akaike information criterion performed well in tests on real data and noisy synthetic data.
Production of Artificiai Fulgurite by Utilizing Rocket Triggered Lightning (1997)

Fulgurite is a kind of mineral produced along the passage of lightning current in the sand, rock, etc., and is characterized by some natural quartz glasses. The production mechanism of fulgurite has not yet been clarified because the lightning is an accidental phenomenon.In the present study, the authors succeeded in the artificial production of the fulgurite from the prepared materials in a container, passing through it lightning currents triggered by rockets.The authors performed the physical and chemical analysis of this fulgurite.So, we will explain the facts that we have observed.(1) We have found the production mechanism of fuigurite.(2) The passage of lightning current is instantaneous (ms). The temperature of the rock rose higher than 1000°C, and was dissipated in the next moment. The cross section of fulgurite has been studied by SEM. It has been found that two kinds of patches, a patch of unaltered material and a patch of the material solidified after the melting, coexist in the small area of a few mm2.It is believed that this is the first success in the artificial production of fulgurite by utilizing rocket triggered lightning in the world.
Metalle in der Medizin (1999)

Nicht nur die etwa 24 essentiellen Elemente, sondern auch nichtessentielle und sogar radioaktive Elemente verfügen über ein enormes medizinisches Potential. Im Kampf gegen Krebs steht Cisplatin, eines der meistverkauften Cytostatica, nicht allein: Andere Platin- sowie Ruthenium- und Titankomplexe werden ebenfalls eingesetzt. Gadolinium(III)-Komplexe können gefahrlos als Kontrastmittel für die NMR-Mikroskopie genutzt werden, und mit den „richtigen”︁ Liganden ist die gezielte Freisetzung von paramagnetischen Ionen sowie von radiodiagnostischen (z. B. 99mTc) und radiotherapeutischen Isotopen (z. B. 186Re) möglich. Superoxid-Dismutase-Mimetica auf Manganbasis, Insulin-Mimetica auf Vanadiumbasis, NO-Fänger auf Rutheniumbasis, Photosensibilisatoren auf Lanthanoidbasis und organische Verbindungen, die gezielt mit Metallionen reagieren, zeigen ein faszinierendes medizinisches Potential.
Preparation of Tl2Ba2CaCu2O8 superconducting thin films on LaAlO3 substrates from metalorganic-chemical-vapor-deposition-prepared precursor films (1991)

Single phase Tl2Ba2CaCu2O8 thin films have been deposited on single-crystal LaAlO3 substrates, (100) orientation, via a two-step deposition process. First, Ba-Ca-Cu-O precursor films were deposited by metalorganic chemical vapor deposition (MOCVD) using barium, calcium, and copper-tetramethyl-heptanedionate, (tmhd)2, source materials under reduced pressure in an oxygen/argon atmosphere. Substrate temperatures were between 500 and 600 °C. Thallium was then incorporated by heating the films in a confined surface configuration with an unfired pellet of Tl2Ba2CaCu2Ox composition at 870 °C for 0.1 h. The resultant films (0.5–1 μm thick) showed a preferred orientation with the c axis normal to the substrate. The superconducting properties were characterized by resistance and mutual inductance versus temperature and by critical current measurements. Zero resistance temperatures as high as 98 K and Jc values close to 1×104 A/cm2 at 77 K were observed.
Cellular environment-responsive nanomaterials for use in gene and siRNA delivery: molecular design for biomembrane destabilization and intracellular collapse (2016)

Currently, the main target of the nanocarrier-mediated siRNA delivery systems is liver. The targeting of non-hepatic tissue is the next challenge. In this case, the design of neutral particle with well-organized intracellular trafficking, as well as an identification of the promising ligand is needed.
Non-iterative joint channel equalisation and channel decoding (2003)

A non-iterative turbo equaliser scheme is proposed, which outperforms the iterative turbo equaliser by about 0.7 dB at a BER of 10/sup -3/ over a symbol-spaced two-path channel and by about 3.4 dB at a BER of 10/sup -3/ over a five-path Gaussian channel.
Effect of ethmoid sinus cavity on dose distribution at interface and how to correct for it: Magnetic field with photon beams (2003)

Recent work proposed the use of magnetic field as a solution to reduce the undesirable effect of air cavities on dose after the air/tissue interface. In contrast to the published work that looks into the problem with slab geometries, in this work we use actual anatomy based on CT images and the magnetic flux from a Helmholtz coil-pair configuration to investigate the problem and to evaluate the efficacy of the proposed solution. The EGS4 phantom was created using CT scans of the head at the level of the ethmoid sinus. The sinus measures 1.95 x 2.18 x 2.00 cm3. The grid size used is 0.15 x 0.15 x 0.4 cm3. Three different radiation beams, 1 x 1, 2 x 2, and 4 x 4 cm2, all 6 MV irradiate the phantom in two different configurations: single beam and parallel opposed. The magnetic field has three different strengths: 0.0, 0.5, and 1.0 T. These represent the maximum strength achieved in the middle of the configuration, between the two coils. The depth of the second buildup region in the absence of the magnetic field was used as the normalization point for the purpose of analysis. Dose was then scored at 0.23 cm after the air/tissue interface. A second phantom, very similar to the CT-based phantom, was created, but with the sinus cavity filled with unit-density tissue; everything else remained the same. This phantom provides a base to investigate the effect of the air cavity on dose. The phantom was termed the phantom without air, or PWA for short. We use the terms "dose reduction ratio" (DRR), defined as one minus the ratio of the dose in PWA to the dose with the presence of the cavity multiplied by 100% and the "dose improvement ratio" (DIR), defined as the ratio of dose with B to that without B, to evaluate the reduction in dose due to the cavity and the improvement in dose with magnetic field, respectively. For single beam geometry, the reduced dose ranged from 41% (1 x 1 cm2 beam) to less than 2% (4 x 4 cm2 beam). For the same single beam geometry, DIR ranged from 1.13 to 1.00 (DIR = 1 indicates no change) with 0.5 T, whereas it ranged from 1.44 to 1.05 for 1.0 T magnets. When an opposing beam was used, the reduced dose was not as severe, such that DRR ranged from 24% to less than 2%. Whereas the dose improvement ranged from 1.08 to 1.00 for 0.5 T, and from 1.23 to 1.01 for 1.0 T.
Phenylthiocarbamide taste sensitivity is associated with sinonasal symptoms in healthy adults (2014)

This study provides evidence that T2R38 functionality in the tongue correlates with nasal symptoms in healthy individuals.
Efficient Scalable Hydrothermal Synthesis of MnO2 with Controlled Polymorphs and Morphologies for Enhanced Battery Cathodes (2023)

MnO2 is a versatile, cost-effective transition metal oxide that has attracted interest in multiple domains, including as an active cathode material or catalyst for electrochemical energy storage in batteries. Hydrothermal methods are among the most efficient approaches for MnO2 synthesis. These approaches enable facile, versatile production of MnO2 in any of its crystalline phases (α, β, δ, etc.), with the dominant product being determined by reaction conditions such as precursor concentration and temperature. These benefits unfortunately come with impractically low product yields (∼9%) and long reaction times. Here, we report that low-molecular weight, water-soluble polymers function as effective nucleating agents for the hydrothermal synthesis of MnO2. For fundamental reasons, these polymers are also reported to promote large (10- to 40-fold) increases in reaction rate and yield. We evaluate the physical and crystallographic features of the synthesized MnO2 and find that depending upon the reaction conditions, the polymer-assisted synthesis yields dominantly δ-MnO2 or β-MnO2. The as-prepared δ-MnO2 materials with extra interlayer water are studied as electrodes for aqueous Zn-ion battery applications and are shown to support long-duration storage at both moderate and high rates.
A Study of Factors Affecting CO2 Corrosion and Inhibitor Effectiveness Using a Multi-Phase Flowloop (2009)

Abstract A mini-flowloop was developed to study CO2 corrosion and corrosion/erosion interactions, and to assess the effectiveness of inhibitors under conditions that simulate multi-phase pipelines. The mini-flowloop was used to study the effect of testing time, steel chemistry, velocity, temperature, fluid chemistry, sand and inhibitors on corrosion rates. The measured corrosion rates in inhibited and uninhibited solutions using the mini-flowloop were significantly different from those measured using other methods such as the Greene cell method. The effect of adding 1/2% Cr to the steel did not improve its CO2 corrosion resistance as has been claimed by some suppliers. The presence of oil in a brine solution increased the corrosion rates for both inhibited and uninhibited solutions. The CO2 corrosion rate increased slightly with increasing flow rate suggesting that the corrosion mechanism is partially diffusion controlled. At high flow rates, the presence of sand enhanced corrosion of steel in both uninhibited and inhibited solutions while at low flow rates sand had no effect on corrosion rates in uninhibited solutions, but it had a profound effect on the rates in inhibited solutions. The water soluble inhibitor was effective in controlling uniform corrosion, but failed to control pitting corrosion for tests conducted in 100% water solution. In 90% water-10% oil solution, the effectiveness of the inhibitor decreased and the corrosion rate increased compared to the oil-free case, but pitting was not observed. When a de-emulsifier was added to a solution inhibited by the water soluble inhibitor, corrosion rate increased dramatically. The oil soluble inhibitor was not successful in controlling pitting corrosion at low flow rates or uniform corrosion at high flowrates.
Recruitment and gene expression profile of mononuclear phagocytes during E. tenella infection: influence of microbiota (2022)

International audience
The preparation and biodistribution of a technetium-99m triaminodithiol complex designed to reflect regional cerebral blood flow (1985)

Recently, interest in the development of radiotracers for brain imaging has increased. Technetium complexes of diaminodithiol (DADT) ligands have been shown to be stable, neutral, lipid soluble, and shown to cross the blood:brain barrier. A new ligand, N-Piperidinylethyl-DADT has been synthesized which forms two complexes with Tc-99m when stannous chloride is used as a reducing agent for Tc-99m pertechnetate. Biodistribution studies of both complexes in mice showed one to have a 2.2% of the injected dose of the tracer in the brain at 5 minutes post intravenous injection with 0.53% of the dose remaining in the brain at 30 minutes post injection. Brain-to-blood ratios at these times were 5.3 and 3.0 respectively. Imaging studies were conducted in a monkey and a baboon in which rapid uptake of the tracer in the brain was observed and clear brain images were obtained. Time activity curves showed peak uptake in the brain at approximately 5 to 7 minutes post intravenous injection followed by a plateau of about 11 minutes. The half-lives for clearance of the tracer from the brains of the monkey and baboon were found to be 63 and 58 minutes respectively. This preliminary evaluation suggests that this tracer shows promise formore » brain imaging in humans.« less
Nonlinear analysis for hardware Trojan detection (2015)

As an important content of chip security, Hardware Trojan detection has attracted a lot of attention. The existing Hardware Trojan detection methods based on side-channel power consumption are effective. The main existing Hardware Trojan detection methods based on side-channel power consumption analysis mainly concentrate on linear features but ignore the features of Hardware Trojan in nonlinear space. This paper proposes a nonlinear detection method based on side-channel power consumption information, it extracts and magnifies features of Hardware Trojan in nonlinear space and achieves Hardware Trojan detection. The results of experiment show that the nonlinear analysis method proposed in this paper can detect the Hardware Trojan effectively in nonlinear space.