gebhart/patrepeval huggingface dataset:
Characterization and processing of blends of polyethylene terephthalate with several liquid crystalline polymers (1990)

Abstract Blends of an engineering thermoplastic, poly(ethylene terephthalate) (PET), and two liquid crystalline polymers (LCPs) viz., copolyesters of PET and parahydrox‐ybenzoic acid (PHB) in 40/60 mole percent (LCP60) and in 20/80 mole percent (LCP80) were prepared. A blend of LCP60 and LCP80 in 50/50 weight percent (LCP60‐80) was blended with PET. Both flat films and rods were extruded and their properties examined. The morphology of the films investigated using Scanning Electron Microscopy (SEM) revealed that the LCP phase remained as dispersed droplets in the PET matrix. In spite of the lack of fibrillation in these films, the mechanical properties were enhanced to some extent with a maximum at 10 weight percent of the LCP phase. However, in the case of the rods thin fibrils of the LCP phase of the order of 1 μm in diameter were observed provided the composition of the LCP was 20 weight percent or greater. This success In achieving fibrillation is through to be due to the extensional flow fields present at the entrance of the capillary die and the fact that a short L/D ratio die was used. Differential Scanning Calorimetry (DSC) thermograms of the extruded films indicated that the LCP phase may act as a nucleating agent for the crystallization of PET. Rheology of the blends revealed that the complex viscosity of the blends is not much different from that of pure PET. This is attributed to the partial miscibility of the two components. Based on the DSC results and residence times in the extruder, it is concluded that no significant transesterification reactions appear to have: taken place in the blends. The rheology is studied further with respect to the cooling behavior of the pure components and factors important to the fibrillation of the LCP phase and the formation of in ‐ situ reinforced composites are discussed.
Re: Targeted Delivery of a Cisplatin Prodrug for Safer and More Effective Prostate Cancer Therapy In Vivo (2011)

No AccessJournal of UrologyInvestigative Urology1 Oct 2011Re: Targeted Delivery of a Cisplatin Prodrug for Safer and More Effective Prostate Cancer Therapy In Vivo Anthony AtalaM.D. Anthony AtalaAnthony Atala More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.06.017AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Targeted Delivery of a Cisplatin Prodrug for Safer and More Effective Prostate Cancer Therapy In Vivo." The Journal of Urology, 186(4), pp. 1553–1554 © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 186Issue 4October 2011Page: 1553-1554 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony Atala More articles by this author Expand All Advertisement PDF downloadLoading ...
Lipoprotein lipase during heparin infusion: lower activity in hemodialysis patients (2003)

Background: Patients on hemodialysis often have a moderate hypertriglyceridemia in combination with low HDL cholesterol. A contributing factor may be a derangement of the lipoprotein lipase (LPL) system. During dialysis, with heparin as anticoagulant, the enzyme is released into the circulating blood. Methods: We have followed LPL activity and triglycerides during ordinary heparin administration in nine hemodialysis patients and controls matched for age and gender. Blood samples were drawn before heparin administration and at 15, 30, 60, 120, 180 and 240 min. Results: LPL activity peaked at 15 or 30 min and then decreased to a plateau that was only 20% of the peak. The activity was reduced in the patients by about 50% during the peak, and about 20% during the following plateau. During the peak of lipase activity the triglycerides decreased in both groups, but the change was less pronounced in patients, as was expected from the lower circulating lipase activity. During the plateau phase with low lipase activity, the triglycerides increased towards baseline values. Conclusions: During hemodialysis with heparin, there is a peak in LPL activity as well as a reduction in triglycerides during the first hour. Thereafter LPL activity decreases towards a plateau, while triglycerides increase towards baseline. The peak activity of LPL in the patients was only half that in controls, while the plateau was comparable. The data indicate that during and following each dialysis there is a period when LPL activity becomes depleted to a level that is limiting for normal lipoprotein metabolism.
Cognitive Reserve–Mediated Modulation of Positron Emission Tomographic Activations During Memory Tasks in Alzheimer Disease (2004)

Brain regions where systematic relationships (slopes) between subjects' education-IQ and brain activation differ as a function of disease status may mediate the differential ability to cope with (ie, delay or modify) clinical manifestations of AD.
HIGH-GRADIENT MEMS ELECTROMAGNETS FOR PARTICLE BEAM MANIPULATION (2014)

We present the first experimental demonstration of MEMSbased magnetic optics for control of charged particle beams. Combined function (steering and focusing) 4-pole electromagnets with a 600-m bore and 55-m yoke thickness (686-m magnetic length) have been fabricated with a novel MEMS process. These 3D solenoidal multi-pole electromagnets have demonstrated hysteresis-free adjustable 2D steering and focusing of a pC-charge 34-keV electron beam with 24-mT field intensity, 220-T/m field gradient, and potential for pulsed operation beyond 100 kHz. Simple geometric optimizations promise a 4-fold improvement in both field intensity and gradient without further scaling.
Fine Structure of Poly-β-Hydroxybutyric Acid Granules in a Blue-Green Alga, Chlorogloea fritschii (1971)

Granules characterized as poly-beta-hydroxybutyric acid are described in Chlorogloea fritschii, a blue-green alga. They are generally spherical inclusions of slight electron density which are limited by a membrane approximately 3 nm in thickness.
System-in-Package, a Combination of Challenges and Solutions (2007)

System-in-package (SiP) has recently become a significant technology in the semiconductor industry, offering to the consumer applications many new product features without increasing the overall form factor. In this talk, the basic SiP concepts are first discussed, showing difference between SiP and SoC, illustrated by some examples, drawn from real-life cases. The specific challenges are considered from the testing point of view, focussing on the assembled yield and defect level for the packaged SiP. Various bare-die test techniques to find known-good-dies are described including their limitations, followed by two techniques to test the SiP at the system level: functional system test and embedded component test. A brief discussion on future SiP design and test challenges concludes the presentation.
Thermodynamic Considerations Related to Knock: Results From an Engine Cycle Simulation (2018)

The design and development of high efficiency spark-ignition engines continues to be limited by the consideration of knock. Although the topic of spark knock has been the subject of comprehensive research since the early 1900s, little has been reported on the coupling of the engine thermodynamics and knock. This work uses an engine cycle simulation together with a submodel for the knock phenomena to explore these connections. First, the autoignition characteristics as represented by a recent (2014) Arrhenius expression for the reaction time of the end gases are examined for a range of temperatures and pressures. In spite of the exponential dependence on temperature, pressure appears to dominate the ignition time for the conditions examined. Higher pressures (and higher temperatures) tend to enhance the potential for knock. Second, knock is determined as function of engine design and operating parameters. The trends are consistent with expectations, and the results provide a systematic presentation of knock occurrence. Engine parameters explored include compression ratio, engine speed, inlet pressure, start of combustion, heat transfer, and exhaust gas recirculation (EGR). Changes of cylinder pressures and temperatures of the unburned zone as engine parameters were varied are shown to be directly responsible for the changes of the knock characteristics.
An efficient scheduling algorithm for QoS in wireless packet data transmission (2003)

In this paper, we proposed an efficient packet scheduling scheme, where the tradeoff of channel condition and QoS (quality of service) is factored according to the user traffic. It can be performed by adding the exponent term to the part of DRC (data rate control) which indicates the channel condition, in the proportional fair algorithm. With measuring the current level of supporting the QoS and controlling the DRC exponent, the proposed scheme can enhance the overall throughput without violating the QoS threshold.
P.005 A virtual interdisciplinary diagnostic memory clinic: rural patient and caregiver satisfaction (2023)

Background: Saskatchewan’s Rural and Remote Memory Clinic (RRMC) has provided post-diagnostic virtual dementia care for approximately 19 years. In response to the COVID-19 pandemic and a new need for remote dementia diagnosis , we developed a virtual, team-based, interdisciplinary (neurology, neuropsychology, nursing), diagnostic memory clinic (vRRMC). We evaluated patient and caregiver satisfaction with the new virtual clinic. Methods: Semi-structured telephone interviews were conducted with rural vRRMC patients (n=7), caregivers (n= 13), and one patient/caregiver dyad. Ages of respondents ranged from 40 to 70 years old (60% female). Level of diagnosed cognitive dysfunction ranged from subjective cognitive impairment to major neurocognitive disorder. Respondents saved an average of 460 km of travel compared to a trip to Saskatoon. Results: Thematic analysis of responses revealed universal satisfaction with the virtual model. The technology training sessions, offered prior to the first vRRMC visit, was described as important for satisfaction. Analysis of preference for future visits revealed more nuance; some preferred in-person visits and planned to travel for future appointments post-pandemic, while others preferred to maintain the virtual model due to perceived travel burden (cost, time, and inconvenience). Conclusions: When clinically appropriate, virtual diagnostic memory clinics should persist as an option post pandemic for families who experience high travel burden.
Screening Piety, Class, and Romance in Indonesia (2020)

Abstract The collapse of the New Order ushered in what many had hoped would be a new era of openness and transparency for Indonesia. The loosening of laws pertaining to broadcast and print publication gave rise to a proliferation of new media and cultural production. This had a profound effect on everything, from politics, religion, and the economy to popular conceptions of romantic intimacy and personal accomplishment. The question is whether prevailing approaches to media and popular culture are adequate to the task of accounting for these oft-cited transformations in Indonesian public life. Focusing on issues of piety, class, and romance, this article examines a sequence of films, pop songs, and YouTube parody videos to offer a presuppositional critique of the current scholarship. Its central contention is that closer attention to pop culture as a form of ‘argument’ offers an important corrective to the reifying tendencies of prevailing approaches.
Computers do not make art, people do (2020)

The continually evolving relationship between artistic technologies and artists.
Comparison between theory and experiment for turbulence in opposed streams (1993)

Experimental data on the mean axial velocity and the intensity of the radial and axial velocity components on the axis of counterflowing turbulent streams are compared with a previously published Reynolds stress theory. Agreement is found to be satisfactory.
DETECTION OF PERIVASCULAR BLOOD FLOW IN VIVO BY CONTRAST‐ENHANCED INTRACORONARY ULTRASONOGRAPHY AND IMAGE ANALYSIS: AN ANIMAL STUDY (2007)

1. Acute coronary syndromes are mostly the result of coronary plaque rupture. Diagnostic techniques focusing on the early detection of those plaques that are prone to rupture are still limited. Increased neovascularization in the adventitia and within the atherosclerotic plaque have recently been identified as common features of inflammation and plaque vulnerability. Contrast-enhanced intravascular imaging with microbubbles can be used to trace perfusion. 2. In the present study, we examined the perivascular network of the left anterior descending coronary arteries and left circumflex arteries of four domestic, clinically healthy pigs using intracoronary ultrasound after injection of microbubbles with a differential imaging technique (ACES; Computational Biomedicine Laboratory, University of Houston, Houston, TX, USA). Our aim was to detect blood flow into the coronary lumen and perivascular flow in contrast-enhanced images. Eleven regions of interest (ROI), including perivascular structures, were compared with regard to their grey scale level before and after the injection of SonoVue (0.06 mL/kg; Bracco Diagnostics, Princeton, NJ, USA). 3. A statistically significant (P = 0.018) enhancement was found in the echogenicity of the total perivascular space (adventitial region and perivascular vessels), as indicated by an increase in grey level intensity from 8.33 +/- 0.80 (before) to 10.11 +/- 0.88 (after microbubble injection). A significant enhancement of the 11 selected ROI (perivascular structures) was also recorded after the injection of microbubbles (from 7.92 +/- 2.14 to 14.03 +/- 2.44; P = 0.008). 4. We believe that the detection of perivascular structures with contrast-enhanced intracoronary ultrasonography combined with proper image processing may reinforce our future efforts in the detection of vasa vasorum, an active participant in the creation of acute coronary events.
CHK1 Inhibition Synergizes with Gemcitabine Initially by Destabilizing the DNA Replication Apparatus (2015)

Combining cell-cycle checkpoint kinase inhibitors with the DNA-damaging chemotherapeutic agent gemcitabine offers clinical appeal, with a mechanistic rationale based chiefly on abrogation of gemcitabine-induced G2-M checkpoint activation. However, evidence supporting this mechanistic rationale from chemosensitization studies has not been consistent. Here we report a systematic definition of how pancreatic cancer cells harboring mutant p53 respond to this combination therapy, by combining mathematical models with large-scale quantitative biologic analyses of single cells and cell populations. Notably, we uncovered a dynamic range of mechanistic effects at different ratios of gemcitabine and CHK1 inhibitors. Remarkably, effective synergy was attained even where cells exhibited an apparently functional G2-M surveillance mechanism, as exemplified by a lack of both overt premature CDK1 activation and S-phase mitotic entry. Consistent with these findings, S-G2 duration was extended in treated cells, leading to a definable set of lineage-dependent catastrophic fates. At synergistic drug concentrations, global replication stress was a distinct indicator of chemosensitization as characterized molecularly by an accumulation of S-phase cells with high levels of hyperphosphorylated RPA-loaded single-stranded DNA. In a fraction of these cells, persistent genomic damage was observed, including chromosomal fragmentation with a loss of centromeric regions that prevented proper kinetochore-microtubule attachment. Together, our results suggested a "foot-in-the-door" mechanism for drug synergy where cells were destroyed not by frank G2-M phase abrogation but rather by initiating a cumulative genotoxicity that deregulated DNA synthesis.
Impact of Pubertal Maturation and Chronologic Age on Sex Steroids in Peripubertal Girls (2019)

Chronologic age as well as time relative to onset of puberty provided unique information regarding estradiol and estrone concentrations in peripubertal girls. Serum estrogen concentrations should be evaluated with reference to chronologic age and race.
Intrinsically Honeycomb‐Patterned Hydrogenated Graphene (2021)

Since the advent of graphene ushered the era of 2D materials, many forms of hydrogenated graphene have been reported, exhibiting diverse properties ranging from a tunable bandgap to ferromagnetic ordering. Patterned hydrogenated graphene with micron-scale patterns has been fabricated by lithographic means. Here, successful millimeter-scale synthesis of an intrinsically honeycomb-patterned form of hydrogenated graphene on Ru(0001) by epitaxial growth followed by hydrogenation is reported. Combining scanning tunneling microscopy observations with density-functional-theory (DFT) calculations, it is revealed that an atomic-hydrogen layer intercalates between graphene and Ru(0001). The result is a hydrogen honeycomb structure that serves as a template for the final hydrogenation, which converts the graphene into graphane only over the template, yielding honeycomb-patterned hydrogenated graphene (HPHG). In effect, HPHG is a form of patterned graphane. DFT calculations find that the unhydrogenated graphene regions embedded in the patterned graphane exhibit spin-polarized edge states. This type of growth mechanism provides a new pathway for the fabrication of intrinsically patterned graphene-based materials.
Growth, characterization, and waveguide lasing of Yb3+, Lu3+, Gd3+ co-doped KY(WO4)2 thin layers (2009)

Monoclinic crystals of KY(WO4)2 (KYW) doped with different rare-earth ions are among the highly promising materials for building compact solid-state lasers. We report the liquid phase epitaxy (LPE) growth of 3-5 µm thick KYW:Gd3+, Lu3+, Yb3+ layers for Yb3+ concentrations of 1.2, 1.7, and 2.4 mol% and 30 to 40-µm-thick KYW:Gd3+, Yb3+ (20 mol%) layers. The concentration of the dopants Yb3+, Lu3+, and Gd3+ in the grown film were determined by laser ablation inductively coupled plasma - mass spectrometry (LA-ICP-MS). The growth conditions were optimized, leading to crack-free layers for all investigated Yb3+ concentrations. X-ray investigations have confirmed the high crystallinity of the films. Based on the Gd3+, Lu3+ co-doped thin films, planar waveguide lasers operating on the Yb3+ transition at 1025 nm were demonstrated. Due to the co-doping, resulting in high refractive-index difference between film and substrate, very thin waveguides with strong light confinement were obtained, thus allowing for a pump threshold of laser operation as low as 18 mW. The highest slope efficiency versus absorbed pump power and output power were 82.3% and 195 mW, respectively.
First principle‐based simulation of ethane steam cracking (2010)

Abstract A consistent set of ab initio‐based kinetic and thermodynamic data is applied for the simulation of an ethane steam cracking furnace. The thermodynamic data are calculated using accurate quantum chemical CBS‐QB3 calculations including corrections for hindered internal rotation. The kinetics are obtained from CBS‐QB3‐based group additive models. With these thermodynamic and kinetic data, simulations for pilot and industrial ethane steam cracking reactors over a wide range of process conditions are performed. It is shown that, without adjusting any parameter, the main product yields can be predicted within 15% rel. of the experimentally observed cracking yields. This indicates the tremendous potential of integrating ab initio methods with engineering models for accurate reactor simulations. © 2010 American Institute of Chemical Engineers AIChE J, 2011
ChemInform Abstract: Electrochemical Reduction of Perfluoroacyl Halides. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High-dimensional Time Series Prediction with Missing Values (2015)

High-dimensional time series prediction is needed in applications as diverse as demand forecasting and climatology. Often, such applications require methods that are both highly scalable, and deal with noisy data in terms of corruptions or missing values. Classical time series methods usually fall short of handling both these issues. In this paper, we propose to adapt matrix matrix completion approaches that have previously been successfully applied to large scale noisy data, but which fail to adequately model high-dimensional time series due to temporal dependencies. We present a novel temporal regularized matrix factorization (TRMF) framework which supports data-driven temporal dependency learning and enables forecasting ability to our new matrix factorization approach. TRMF is highly general, and subsumes many existing matrix factorization approaches for time series data. We make interesting connections to graph regularized matrix factorization methods in the context of learning the dependencies. Experiments on both real and synthetic data show that TRMF outperforms several existing approaches for common time series tasks.
Regulator of G‐protein Signaling 2 (RGS2) inhibits androgen‐independent activation of androgen receptor in prostate cancer cells (2006)

Hormones acting through G protein-coupled receptors (GPCRs) can cause androgen-independent activation of androgen receptor (AR) in prostate cancer cells. Regulators of G-protein Signaling (RGS) proteins, through their GTPase activating protein (GAP) activities, inhibit GPCR-mediated signaling by inactivating G proteins. Here, we identified RGS2 as a gene specifically down-regulated in androgen-independent prostate cancer cells. Expression of RGS2, but not other RGS proteins, abolished androgen-independent AR activity in androgen-independent LNCaP cells and CWR22Rv1 cells. In LNCaP cells, RGS2 inhibited Gq-coupled GPCR signaling. Expression of exogenous wild-type RGS2, but not its GAP-deficient mutant, significantly reduced AR activation by constitutively activated GqQ209L mutant whereas silencing endogenous RGS2 by siRNA enhanced GqQ209L-stimulated AR activity. RGS2 had no effect on RGS-insensitive GqQ209L/G188S-induced AR activation. Furthermore, extracellular signal-regulated kinase 1/2 (ERK1/2) were found to be involved in RGS2-mediated regulation of androgen-independent AR activity. In addition, RGS2 functioned as a growth suppressor for androgen-independent LNCaP cells whereas androgen-sensitive LNCaP cells with RGS2 silencing had a growth advantage under steroid-reducedconditions. Finally, RGS2 expression level was significantly decreased in human prostate tumor specimens. Takentogether, our results suggest RGS2 as a novel regulator of AR signaling and its repression may be an important step during prostate tumorigenesis and progression.