gebhart/patrepeval huggingface dataset:
Online-Monitoring der 5-FU-Konzentration über die MRT-Signalintensität bei der Therapie von Lebermetastasen (2005)

Einleitung: Die derzeit effektivste Therapie nichtresektabler Lebermetastasen ist die regionale, intraarterielle Chemotherapie in Erweiterung mit der zusätzlichen Gabe flussverzögernder Stärkemikrosphären (Embolisation). Es stehen jedoch keine effektiven Kontrollmöglichkeiten über die Effektivität der Chemotherapie während der Durchführung zur Verfügung. Die Aufnahme von Therapeutika in das tumortragende Organ und Tumor kann nur indirekt nach Therapieabschluss bildgebend und am klinischen Verlauf beurteilt werden. Ziel der Studie war es, durch Verkopplung von Therapeutikum und Kontrastmittel in Liposomen über das Enhancement im MRT online Information über die Aufnahme von Zytostatika in das Tumorgewebe zu erhalten. Material und Methoden: Hepatische Implantation von CC531-Adeno-Ca Zellen an 10 WAG/Rij-Ratten. Intrarterielle (A. hepatica) Applikation der Therapie-Diagnostik- Liposomen (5-FU-Gd-SUV-PEG) in Kombination mit embolisierenden Stärke-mikrossphären (DSM). MRT-Untersuchung in vivo zum Nachweis des Kontrastmittel-Anreicherungsverhaltens vor und nach. Die Kontrolle der Korrelation mit der 5-FU Gewebekonzentration erfolgte in vitro über Bestimmung der Zytostatikakonzentration in vitro mittels HPLC in Tumor und Leber.
Heparin Microislands in Microporous Annealed Particle Scaffolds for Accelerated Diabetic Wound Healing (Adv. Funct. Mater. 35/2021) (2021)

Porous Hydrogels In article number 2104337, Donald Griffin and co-workers present heterogeneously distributed heparin microislands within a microporous annealed particle hydrogel as a new type of bioactive scaffold that can promote extensive cell migration and enhanced healing without the addition of exogenous growth factors. This innovative materials-only approach has high translational potential for biomedical applications requiring accelerated tissue integration.
N,N‐Dimethylformamide as a Reaction Medium for Metal Nanoparticle Synthesis (2009)

Abstract The versatility of wet chemical methods has rendered them extremely popular for the preparation of metal nanoparticles with tailored size and shape. This Feature Article reviews the use of N , N ‐dimethylformamide (DMF) for the reduction of metal salts, mainly Au and Ag, while also acting as a solvent. Apart from describing the ability of DMF to reduce metal salts, the effect of different parameters, such as the concentration of capping agent and metal precursors, the presence of preformed seeds acting as catalysts or their crystalline structure, on particle morphology are analyzed. Published reports on the use of different capping agents are summarized, with particular emphasis on the role of poly(vinylpyrrolidone) to determine the morphology of the particles. Finally, a brief overview is provided on the modulation of the optical response in DMF‐based metal nanoparticle colloids with tunable size and shape.
Analysis of pencil graphite samples of various origins using instrumental neutron activation analysis (2007)

Instrumental neutron activation analysis (INAA) was applied for multi-element determination in samples of graphite used in manufacturing of pencils. These samples have been randomly selected from the Egyptian market from different manufacturers and of various origins. Some of these samples are imported from the world market and the others are locally made. The determined elements in these samples were: As, Au, Ce, Co, Cr, Cs, Eu, Fe, Hf, La, Lu, Na, Ni, Rb, Sc, Ta, Th, U, W, Yb and Zn. Some of these elements were major or minor elements where others were trace elements. Standard reference material was used in this analysis. Some of the analyzed samples contain some toxic or undesirable elements such as As, Th and U. In addition some of these elements are present in comparatively high concentration.
Application of laser velocimetry to an unsteady transonic flow (1979)

Measurements of mean velocity, turbulent kinetic energy, and turbulent shear stress have been obtained in an unsteady but periodic flow. Polystyrene spheres, 0.35-0.55 microns in diameter, were injected into the tunnel settling chamber to seed the flow for a laser velocimeter. Synchronized counters together with an encoding interface and digital-to-analog converters were used to record the data on an analog tape recorder. Profiles of velocity and turbulence quantities are presented for several times during the periodic flow.
The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum. (1993)

The ryanodine receptor/calcium release channel (CRC) of rabbit skeletal muscle terminal cisternae (TC) of sarcoplasmic reticulum (SR) has been found to be tightly associated with FK-506 binding protein (FKBP-12), the cytosolic receptor (immunophilin) for the immunosuppressant drug FK-506 (Jayaraman, T., Brillantes, A. M., Timerman, A. P., Fleischer, S., Erdjument-Bromage, H., Tempst, P., and Marks, A. (1992) J. Biol. Chem. 267, 9474-9477). In this study, a procedure is described to dissociate FKBP from TC and reconstitute human recombinant FKBP-12 back to the ryanodine receptor so that the role of the immunophilin on CRC activity can be assessed. Titration of TC vesicles with FK-506 dissociates FKBP from the ryanodine receptor. Sedimentation of FK-506-treated vesicles effectively separates the TC from the soluble FKBP-FK506 complex which remains in the supernatant. The FKBP-deficient TC vesicles have altered functional characteristics: 1) the ATP-stimulated calcium uptake rate of TC vesicles is reduced 2-fold; and 2) the threshold concentration of caffeine required to induce calcium release from TC vesicles is decreased. These changes appear to reflect modification of the calcium release channel since: 1) severalfold higher concentrations of FK-506 do not alter the calcium uptake rate of either longitudinal tubules of SR, or TC vesicles in the presence of ruthenium red; 2) human recombinant FKBP reassociates with FKBP-deficient TC but not with control TC or longitudinal tubules of SR; and 3) the reduced Ca2+ uptake rate in FKBP-deficient TC is restored to control values in the FKBP-reconstituted TC. These studies demonstrate that FKBP-12 modulates the CRC of rabbit skeletal muscle sarcoplasmic reticulum.
Lifetimes and NADH quenching of tryptophan fluorescence in pig heart cytoplasmic malate dehydrogenase. (1979)

The time-resolved and steady state fluorescence properties were measured for pig heart cytoplasmic malate dehydrogenase at pH 6.0 and 8.0. The fluorescence decay can be described by two rate processes, according to the functions: I(t) = 0.7e(-t/1.0) + 0.3e(-t/4.4) for the free enzyme and I(t) = 0.7e(-t/0.8) + 0.3e(-t/2.0 for the enzyme . NADH complex. Quenching by NADH of the tryptophan fluorescence is linear. The only effect of pH is to change the association constant for NADH binding; the fluorescence of the free enzyme and the fluorescence quenching by NADH, I-, and acrylamide are unaffected by pH. Thus there are no changes in conformation of the free enzyme or of the NADH complex over the range of pH 6 to 8.
High-Temperature Strength of Directionally Solidified Al<sub>2</sub>O<sub>3</sub>/YAG/ZrO<sub>2</sub> Eutectic Composite (2005)

A2O3/YAG/ZrO2 eutectic Melt-Growth-Composites (MGCs) were unidirectionally solidified by the modified-pulling-down method (MPD) and the Bridgman type method, in which a crucible was brought down at different speeds. The microstructures and crystallographic textures were studied by field emission scanning electron microscopy (FE-SEM) and electron backscattered pattern (EBSP) method. The high-temperature strength was investigated by compression tests. All MGC rods show strong preferred growing orientation, although the structural size of eutectic microstructure among MGC rods was different. The high-temperature strength of MGC rods is dependent on orientation, compression temperature and strain rate. The high-temperature strength of MGC rods is controlled by the anisotropic strength of constituent Al2O3, as well as the structural size of eutectic microstructure.
Novel swing-assist un-motorized exoskeletons for gait training (2009)

We compared two different cases. In case 1, we estimated the torque applied by the human joints when walking with the device using the joint kinematic data and interface force-torque sensors. In case 2, we calculated the required torque to perform a similar gait only using the kinematic data collected from joint motion sensors. On analysis, we found that at 2.0 mph, the device was effective in reducing the maximum hip torque requirement and the knee joint torque during the beginning of the swing. These behaviors were retained as the treadmill speed was changed between 1-4 mph. These results were remarkable considering the simplicity of the dynamic model, model uncertainty, non-ideal spring behavior, and friction in the joints. We believe that the results can be further improved in the future. Nevertheless, this promises to provide a useful and effective methodology for design of un-motorized exoskeletons to assist and train swing of motor-impaired patients.
A Monte Carlo Thermal Radiative Transfer Solver with Nonlinear Elimination (2023)

In this paper, we present a new Monte Carlo method for solving the thermal radiative transfer (TRT) equations via the method of nonlinear elimination (NLEM). This method is inspired by the previous application of NLEM to thermal radiation diffusion. Our approach, called diffusion accelerated Implicit Monte Carlo (DAIMC), is a hybrid technique which combines a Monte Carlo method for solving a purely-absorbing transport equation and a diffusion solution that accounts for effective scattering, or absorption–reemission. The method aims to improve the implicitness of the traditional implicit Monte Carlo (IMC) method. We derive DAIMC generally for 3D Cartesian geometries, but in this paper, we present results and analysis in 1D slab geometry. These preliminary results indicate that DAIMC implementations may provide more accurate and robust TRT solutions than IMC in certain test problems.
Site-specific immobilization of proteins on non-conventional substrates via solvent-free initiated chemical vapour deposition (iCVD) process (2014)

Currently, the development of protein chips faces new requirements of improved environmental stability, disposability, and cost-effectiveness for their wide applicability in our daily life. Here, we demonstrate a new protein detection platform on low-cost plastic and paper substrates. To achieve this platform, a highly selective thiol–ene photochemical reaction between vinyl functionality on the surface and cysteine-linked protein was utilized to immobilize the relevant proteins on the disposable substrates. First, the surface of the flexible substrates was modified with a vinyl-containing polymer, poly(2,4,6,8-tetravinyl-2,4,6,8-tetramethyl cyclotetrasiloxane) (pV4D4), via a solvent-free initiated chemical vapour deposition (iCVD) process. Next, on the vinyl functionalized surface, cysteine-linked proteins were covalently immobilized by a UV-assisted thiol–ene click reaction. The solvent-free characteristic of iCVD enabled us to directly pattern the functionality on the substrate via shadow mask patterning. On the patterned substrate, selective immobilization of the proteins was possible. With four model proteins, including two fluorescent proteins, single-chain variable fragment (scFv), and non-immunoglobulin protein scaffold (human kringle domain), we successfully demonstrated the immobilization of proteins on various substrates including polyethylene (PE) film and chromatography paper.
Characterization of Schwannomin Role in Protein Translation (2001)

Abstract : We demonstrated that schwannomin interacts with the eukaryotic initiation factor 3 (eIF3) p110 subunit eight and now investigate the role of schwannomin in eIF3 function. eIF3 is required for the 40 S ribosomal subunit bound to the ternary complex (eIF2-GTP-methionine) to interact with the 5' end of the mRNA, and is required for progression of protein translation. Keeping with our Objectives and Statement of Work, we have: (1) verified the interaction of schwannomin and p110 by using the non-transcriptionally-based ras-rescue yeast two-hybrid system, (2) produced and validated two high-quality p110 antibodies, (3) determined the cross-reactivity of our anti-p110 antibodies in mouse rat and human cells, (4) co-immunoprecipitated schwannomin and p110 using one of the new p110 antibodies, (5) cloned the full-length p110 cDNA and validated its expression, (6) co-localized p110 and schwannomin in STS26T schwannoma cells by confocal microscopy, (7) developed a NF2 inducible tet-off MEF cell line for the study on p110 function, (8) narrowed the region of p110 interaction in schwannomin to p110 amino acids 327-635 by yeast two-hybrid, (9) cloned eight plasmids for further narrowing of the p110 region of interaction with schwannomin by in vitro methods, and (10) showed the effects of NF2 mutations_on p110 interaction by the yeast two-hybrid method.
Breaking the Computational Bottleneck: Design of Near-Optimal High-Memory Spatially-Coupled Codes (2021)

Spatially-coupled (SC) codes, known for their threshold saturation phenomenon and low-latency windowed decoding algorithms, are ideal for streaming applications and data storage systems. SC codes are constructed by partitioning an underlying block code, followed by rearranging and concatenating the partitioned components in a convolutional manner. The number of partitioned components determines the memory of SC codes. In this paper, we investigate the relation between the performance of SC codes and the density distribution of partitioning matrices. While adopting higher memories results in improved SC code performance, obtaining finite-length, high-performance SC codes with high memory is known to be computationally challenging. We break this computational bottleneck by developing a novel probabilistic framework that obtains (locally) optimal density distributions via gradient descent. Starting from random partitioning matrices abiding by the obtained distribution, we perform low-complexity optimization algorithms that minimize the number of detrimental objects to construct high-memory, high-performance quasi-cyclic SC codes. We apply our framework to various objects of interests, from the simplest short cycles, to more sophisticated objects such as concatenated cycles aiming at finer-grained optimization. Simulation results show that codes obtained through our proposed method notably outperform state-of-the-art SC codes with the same constraint length and optimized SC codes with uniform partitioning. The performance gain is shown to be universal over a variety of channels, from canonical channels such as additive white Gaussian noise and binary symmetric channels, to practical channels underlying flash memory and magnetic recording systems.
Human recombinant glutamate oxaloacetate transaminase 1 (GOT1) supplemented with oxaloacetate induces a protective effect after cerebral ischemia (2014)

Blood glutamate scavenging is a novel and attractive protecting strategy to reduce the excitotoxic effect of extracellular glutamate released during ischemic brain injury. Glutamate oxaloacetate transaminase 1 (GOT1) activation by means of oxaloacetate administration has been used to reduce the glutamate concentration in the blood. However, the protective effect of the administration of the recombinant GOT1 (rGOT1) enzyme has not been yet addressed in cerebral ischemia. The aim of this study was to analyze the protective effect of an effective dose of oxaloacetate and the human rGOT1 alone and in combination with a non-effective dose of oxaloacetate in an animal model of ischemic stroke. Sixty rats were subjected to a transient middle cerebral artery occlusion (MCAO). Infarct volumes were assessed by magnetic resonance imaging (MRI) before treatment administration, and 24 h and 7 days after MCAO. Brain glutamate levels were determined by in vivo MR spectroscopy (MRS) during artery occlusion (80 min) and reperfusion (180 min). GOT activity and serum glutamate concentration were analyzed during the occlusion and reperfusion period. Somatosensory test was performed at baseline and 7 days after MCAO. The three treatments tested induced a reduction in serum and brain glutamate levels, resulting in a reduction in infarct volume and sensorimotor deficit. Protective effect of rGOT1 supplemented with oxaloacetate at 7 days persists even when treatment was delayed until at least 2 h after onset of ischemia. In conclusion, our findings indicate that the combination of human rGOT1 with low doses of oxaloacetate seems to be a successful approach for stroke treatment.
Supplementary Figure 3 from Ionizing Radiation Induces Frequent Translocations with Delayed Replication and Condensation (2023)

Supplementary Figure 3 from Ionizing Radiation Induces Frequent Translocations with Delayed Replication and Condensation
Inbred phenotypic data and non‐additive effects can enhance genomic prediction models for hybrid grain sorghum (2023)

Abstract Implementation of genomic prediction can bolster rates of genetic gain in sorghum improvement and permit more efficient allocation of resources within hybrid breeding programs. In the present study, alternative genomic prediction models were compared to assess the potential benefits of including inbred phenotypic records, dominance effects, and genotype‐by‐environment (G×E) interactions in predicting hybrid grain sorghum performance. Comparisons were made in a set of 395 hybrid combinations derived from 92 parental inbred lines tested in a sparse multi‐environment trial. Phenotypic data were collected on hybrids and inbreds for days to mid‐anthesis, grain yield, and plant height, and genomic data on parental inbreds were collected by genotyping × sequencing. A significant increase in prediction accuracy was observed when modeling G×E effects; however, dominance effects did not contribute to the overall predictive ability of models in this data set. Including phenotypic data from parental lines significantly improved the prediction of hybrid merit by as much as 17% for days to mid‐anthesis, 14% for grain yield, and 33% for plant height when there were no testcross records for a given parental line. Alternatively, similar improvements were not as consistent when the training set included lines already tested in hybrid combinations. Thus, hybrid crop breeders can further optimize genomic predictions for un‐testcrossed lines by including non‐additive effects and inbred data.
Magnetic‐Field Tunable Intertwined Checkerboard Charge Order and Nematicity in the Surface Layer of Sr2RuO4 (Adv. Mater. 32/2021) (2021)

Sr2RuO4 Surface Layers As reported by Peter Wahl and co-workers in article number 2100593, small structural distortions in the surface layer of Sr2RuO4 create a system with radically different properties compared to the bulk, giving rise to multiple van Hove singularities and nematic and checkerboard charge orders. The image shows the structure of the van Hove singularity in reflection from the checkerboard order and nematicity, which are both required to understand the new exciting physics.
Resealed Erythrocytes As Carriers For Salbutamol Sulphate (1995)

Resealed erythrocytes as carriers for salbutamol sulphate were prepared as a novel drug delivery system for controlled release therepy by hypotonic haemolysis technique. In vitro drug release study was carried out by dialysis technique. The product was lyophillised. In vivo studies in guinea pigs using histamine chamber showed promising results.
The challenge of time: Clock‐drawing and cognitive function in the elderly (1986)

Abstract This study compares the ‘clock‐drawing test’ to two standardized cognitive screens in an elderly population. A newly developed hierarchical classification of errors in clock‐drawing correlated well with the severity of scores on both cognitive and screens and also demonstrated acceptable standards for sensitivity and specificity. Clock‐drawing appears to be a practical test which can be useful for clinicians as a screen for cognitive impairment in old age and possibly as a marker of change in cognitive status.
On the Dual Role of N-Heterocyclic Carbenes as Bases and Nucleophiles in Reactions with Organic Halides (2011)

The synthetic consequences of different basicities, nucleophilicities, and sterics of N-heterocyclic carbenes have been studied in reactions of imidazolin-2-ylidenes with organic halides. Highly nucleophilic and less basic carbenes cleanly gave alkyli­deneimidazolines, the deoxy analogues of Breslow-type intermediates. More basic NHCs engaged in unwanted deprotonation or dehydrohalogenation reactions.
Nickel(II) complexes with the [NiNxSey] chromophore in different coordination geometries: search for a model of the active site of [FeNiSe] hydrogenases (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNickel(II) complexes with the [NiNxSey] chromophore in different coordination geometries: search for a model of the active site of [FeNiSe] hydrogenasesNarayan Baidya, Bruce C. Noll, Marilyn M. Olmstead, and Pradip K. MascharakCite this: Inorg. Chem. 1992, 31, 14, 2999–3000Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/ic00040a002https://doi.org/10.1021/ic00040a002research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
21010 Liquid Behavior in Liquid Food Containers under Impact Drop (2014)

Recently, a new container for liquid of food products, which consists of a case made of a sheet of recycled paper and a liquid-packaging bag with a pouring lip made of a plastic film has been developed. The improvement of the resistance of the new container to drop impact is desired because the resistance is not adequately. To improve the resistance, it is important to investigate the relationship between the deformation of the case and the liquid behavior in the bag. In this study, the liquid behavior in the bag inserted in a transparent thin plastic case and the deformation of the case subjected to drop impact was observed using a high speed camera. In addition, the relationship between the deformation of the case and the liquid behavior in the bag was investigated. Results indicated that the deformation of the case was closely related to the liquid behavior in the bag.