gebhart/patrepeval huggingface dataset:
Determination of Pore Sizes and Relative Porosity in Porous Nanoshell Architectures Using Dextran Retention with Single Monomer Resolution and Proton Permeation (2012)

Unilamellar phospholipid vesicles prepared using the polymerizable lipid bis-sorbylphosphatidylcholine (bis-SorbPC) yield three-dimensional nanoarchitectures that are highly permeable to small molecules. The resulting porous phospholipid nanoshells (PPNs) are potentially useful for a range of biomedical applications including nanosensors and nanodelivery vehicles for cellular assays and manipulations. The uniformity and size distribution of the pores, key properties for sensor design and utilization, have not previously been reported. Fluorophore-assisted carbohydrate electrophoresis (FACE) was utilized to assess the nominal molecular weight cutoff limit (NMCL) of the PPN via analysis of retained dextran with single monomer resolution. The NMCL of PPNs prepared from pure bis-SorbPC was equivalent to a 1800 Da linear dextran, corresponding to a maximum pore diameter of 2.6 nm. Further investigation of PPNs prepared using binary mixtures of bis-SorbPC and dioleoylphosphatidylcholine (DOPC) revealed a similar NMCL when the bis-SorbPC content exceeded 30 mol %, whereas different size-dependent permeation was observed below this composition. Below 30 mol % bis-SorbPC, dextran retention provided insufficient mass resolution (162 Da) to observe porosity on the experimental time scale; however, proton permeability showed a marked enhancement for bis-SorbPC ≥ 10 mol %. Combined, these data suggest that the NMCL for native pores in bis-SorbPC PPNs results from an inherent property within the lipid assembly that can be partially disrupted by dilution of bis-SorbPC below a critical value for domain formation. Additionally, the analytical method described herein should prove useful for the challenging task of elucidating porosity in a range of three-dimensional nanomaterials.
SU(3) Quantum Hall Ferromagnetism in SnTe (2016)

The (111) surface of SnTe hosts one isotropic Γ[over ¯]-centered and three degenerate anisotropic M[over ¯]-centered Dirac surface states. We predict that a nematic phase with spontaneously broken C_{3} symmetry will occur in the presence of a perpendicular magnetic field when the N=0 M[over ¯] Landau levels are 1/3 or 2/3 filled. The nematic state phase boundary is controlled by a competition between intravalley Coulomb interactions that favor a valley-polarized state and weaker intervalley scattering processes that increase in relative strength with magnetic field. An in-plane Zeeman field alters the phase diagram by lifting the threefold M[over ¯] Landau-level degeneracy, yielding a ground state energy with 2π/3 periodicity as a function of Zeeman-field orientation angle.
A rotary electromagnetic microgenerator for energy harvesting from human motions (2016)

In this paper, a rotary electromagnetic microgenerator is analyzed, designed and built. This microgenerator can convert human motions to electrical energy. The small size and use of a pendulum mechanism without gear are two main characteristics of the designed microgenerator. The generator can detect small vibrations and produce electrical energy. The performance of this microgenerator is evaluated by being installed peak-to-peak during normal walking. Also, the maximum harvested electrical energy during normal walking is around 416.6 μW. This power issufficient for many applications.
Different mechanisms of action of poly(ethylene glycol) and arginine on thermal inactivation of lysozyme and ribonuclease A (2012)

Abstract Proteins tend to undergo irreversible inactivation through several chemical modifications, which is a serious problem in various fields. We have recently found that arginine (Arg) suppresses heat‐induced deamidation and β‐elimination, resulting in the suppression of thermal inactivation of hen egg white lysozyme and bovine pancreas ribonuclease A. Here, we report that poly(ethylene glycol) (PEG) with molecular weight 1,000 acts as a thermoinactivation suppressor for both proteins, especially at higher protein concentrations, while Arg was not effective at higher protein concentrations. This difference suggests that PEG, but not Arg, effectively inhibited intermolecular disulfide exchange among thermally denatured proteins. Investigation of the effects of various polymers including PEG with different molecular weight, poly(vinylpyrolidone) (PVP), and poly(vinyl alchol) on thermoinactivation of proteins, circular dichroism, solution viscosity, and the solubility of reduced and S ‐carboxy‐methylated lysozyme indicated that amphiphilic PEG and PVP inhibit intermolecular collision of thermally denatured proteins by preferential interaction with thermally denatured proteins, resulting in the inhibition of intermolecular disulfide exchange. These findings regarding the different mechanisms of the effects of amphiphilic polymers––PEG and PVP––and Arg would expand the capabilities of methods to improve the chemical stability of proteins in solution. Biotechnol. Bioeng. 2012; 109: 2543–2552. © 2012 Wiley Periodicals, Inc.
Histoire d'un conflit de travail: Grands Magasins Bruxellois - Octobre-Décembre 1950 (1950)

info:eu-repo/semantics/published
Towards 3D Modeling of Buildings using Mobile Augmented Reality and Aerial Photographs (2009)

This paper presents an online partial 3D modeling methodology that uses a mobile augmented reality system and aerial photographs, and a tracking methodology that compares the 3D model with a video image. Instead of relying on models which are created in advance, the system generates a 3D model for a real building on the fly by combining frontal and aerial views. A user's initial pose is estimated using an aerial photograph, which is retrieved from a database according to the user's GPS coordinates, and an inertial sensor which measures pitch. We detect edges of the rooftop based on Graph cut, and find edges and a corner of the bottom by minimizing the proposed cost function. To track the user's position and orientation in real-time, feature-based tracking is carried out based on salient points on the edges and the sides of a building the user is keeping in view. We implemented camera pose estimators using both a least squares estimator and an unscented Kalman filter (UKF). We evaluated the speed and accuracy of both approaches, and we demonstrated the usefulness of our computations as important building blocks for an Anywhere Augmentation scenario.
Conjugated Linoleic Acid Does Not Improve Insulin Tolerance in Mice* (2003)

Mice fed CLA did not have improved insulin tolerances compared with control mice. In some cases, dietary CLA may cause insulin resistance. MH mice seem more sensitive to CLA than ML mice.
Feeding native laying hens diets containing palm kernel meal with or without enzyme supplementations: 1. Feed conversion ratio and egg production (2011)

Oil extraction from the palm kernel produces a large amount of palm kernel meal (PKM), a by-product having considerable potential nutritive value for poultry. Increasing its use and improving its nutritive value in poultry diets is especially important in palm oil-producing countries. This study was aimed at evaluating the effect of the inclusion level of PKM in laying hen diets on egg production and egg quality. One hundred eighty 48-wk-old native laying hens were assigned to 180 cages (1 bird per cage) in a curtain-sided house. Diets were assigned at random to 15 cages each. The experimental diets resulted from a factorial combination of 3 levels of PKM (0, 15, and 30%), 2 levels of a fiber-degrading enzyme [0 and 15 units of β-glucanase (major enzyme) activity/kg of diet; Ronozyme VP, DSM Nutritional Products Inc., Basel, Switzerland], and 2 levels of phytase + protease mixture [0 and 2,000 units of phytase (Ronozyme NP) + 12,500 units of protease (Ronozyme ProAct) activity/kg of diet; both products of DSM Nutritional Products Inc.]. Diets were isocaloric (2,758 kcal of ME/kg) and contained 17.51 to 18.39% CP, and were provided ad libitum together with water for the 6-wk trial. Six-week feed intake increased as the PKM level increased (3,573 vs. 3,791 vs. 4,022 g/hen for the hens fed 0, 15, and 30% PKM, respectively; P ≤ 0.008). Levels of PKM did not affect egg production, feed conversion, or egg weight. Egg quality traits (albumen height, Haugh units, eggshell thickness, and egg surface area) of hens fed 15 or 30% PKM were comparable with those fed the 0% PKM (corn and soybean meal) except that yolk color was paler when the PKM diets were fed (8.15 vs. 7.08 vs. 5.61 for the hens fed 0, 15, and 30% PKM, respectively; P ≤ 0.0001). Because PKM inclusion resulted in no deleterious effects on egg production and quality, no effects of enzyme supplementation could be measured. Depending on consumer preference, a carotenoid source may be needed when PKM is included in the diet at levels of 15% or above.
The effects of spherical aberration on multiphoton fluorescence excitation microscopy (2010)

Multiphoton fluorescence excitation microscopy is almost invariably conducted with samples whose refractive index differ from that of the objective immersion medium, conditions that cause spherical aberration. Due to the quadratic nature of multiphoton fluorescence excitation, spherical aberration is expected to profoundly affect the depth dependence of fluorescence excitation. In order to determine the effect of refractive index mismatch in multiphoton fluorescence excitation microscopy, we measured signal attenuation, photobleaching rates and resolution degradation with depth in homogeneous samples with minimal light scattering and absorption over a range of refractive indices. These studies demonstrate that signal levels and resolution both rapidly decline with depth into refractive index mismatched samples. Analyses of photobleaching rates indicate that the preponderance of signal attenuation with depth results from decreased rates of fluorescence excitation, even in a system with a descanned emission collection pathway. Similar results were obtained in analyses of fluorescence microspheres embedded in rat kidney tissue, demonstrating that spherical aberration is an important limiting factor in multiphoton fluorescence excitation microscopy of biological samples.
Detection of High Frequency Oscillations with Teager Energy in an Animal Model of Limbic Epilepsy (2006)

High frequency oscillations (HFO) in limbic epilepsy represent a marked difference between abnormal and normal brain activity. Faced with the difficult of visually detecting HFOs in large amounts of intracranial EEG data, it is necessary to develop an automated process. This paper presents Teager Energy as a method of finding HFOs. Teager energy is an ideal measure because unlike conventional energy it takes into account the frequency component of the signal as well as signal amplitude. This greatly aids in the dissection of HFOs out of the noise and other signals contained in the EEG. Therein, Teager energy analysis is able to detect high-frequency, low-amplitude components that conventional energy measurements would miss.
Postural control characterization according to age and auditory input in cochlear implant users (2020)

<b>Aims/Objectives:</b> Understand the relationship between auditory input and balance motor control. <b>Material and Methods:</b> Twelve prelingual adolescent cochlear implant users (CIU) and 12 adult postlingual CIU were tested by posturography on a force platform with eyes open in two conditions, with the cochlear implant (CI) on and off. Energy consumption (EC) of the body center of pressure sway signal was measured, calculating total EC and divided into three bands of frequencies; low (B1) 0-0.1 Hz, medium (B2) 0.1-1 Hz, and high (B3)1-2 Hz. Wilcoxon and Mann-Whitney tests were used for statistical analysis and the significance level was <i>P </i>≤ 0.05. <b>Results:</b> Prelingual CIU decrease the EC in low and high frequencies throughout the adolescence (<i>P </i>< 0.05) assessed with the CI turned on, while it did not show any modification with the CI off. Postlingual CIU showed a deterioration of PR related to aging when evaluated with the CIU turned off, <i>P </i>< 0.05 in band 1. However, with the CI turned on they had no significant increase in this age range. <b>Conclusions and Significance:</b> The acoustic input improved EC of postural responses in higher and lower frequencies in adolescence and with aging which suggests a relationship with gross and fine movements involved in postural control.
Calcium‐ and magnesium‐dependent interactions between calcium‐ and integrin‐binding protein and the integrin αIIb cytoplasmic domain (2005)

Calcium- and integrin-binding protein (CIB) is a small EF-hand calcium-binding protein that is involved in hemostasis through its interaction with the alphaIIb cytoplasmic domain of integrinalphaIIbbeta(3). We have previously demonstrated that CIB lacks structural stability in the absence of divalent metal ions but that it acquires a well-folded conformation upon addition of Ca(2+) or Mg(2+). Here, we have used fluorescence spectroscopy, NMR spectroscopy, and isothermal titration calorimetry to demonstrate that both Ca(2+)-bound CIB (Ca(2+)-CIB) and the Mg(2+)-bound protein (Mg(2+)-CIB) bind with high affinity and through a similar mechanism to alphaIIb cytoplasmic domain peptides, but that metal-free CIB (apo-CIB) binds in a different manner. The interactions are thermodynamically distinct for Ca(2+)-CIB and Mg(2+)-CIB, but involve hydrophobic interactions in each case. Since the Mg(2+) concentration inside the cell is sufficient to saturate CIB at all times, our results imply that CIB would be capable of binding to the alphaIIb cytoplasmic domain independent of an intracellular Ca(2+) stimulus in vivo. This raises the question of whether CIB can act as a Ca(2+) sensor in alphaIIbbeta(3) signaling or if other regulatory mechanisms such as fibrinogen-induced conformational changes in alphaIIbbeta(3), post-translational modifications, or the binding of other accessory proteins mediate the interactions between CIB and alphaIIbbeta(3). Differences in NMR spectra do suggest, however, that Ca(2+)-binding to the Mg(2+)- CIB-alphaIIb complex induces subtle structural changes that could further modulate the activity of alphaIIbbeta(3).
OrthoInspector 3.0: open portal for comparative genomics (2018)

OrthoInspector is one of the leading software suites for orthology relations inference. In this paper, we describe a major redesign of the OrthoInspector online resource along with a significant increase in the number of species: 4753 organisms are now covered across the three domains of life, making OrthoInspector the most exhaustive orthology resource to date in terms of covered species (excluding viruses). The new website integrates original data exploration and visualization tools in an ergonomic interface. Distributions of protein orthologs are represented by heatmaps summarizing their evolutionary histories, and proteins with similar profiles can be directly accessed. Two novel tools have been implemented for comparative genomics: a phylogenetic profile search that can be used to find proteins with a specific presence-absence profile and investigate their functions and, inversely, a GO profiling tool aimed at deciphering evolutionary histories of molecular functions, processes or cell components. In addition to the re-designed website, the OrthoInspector resource now provides a REST interface for programmatic access. OrthoInspector 3.0 is available at http://lbgi.fr/orthoinspectorv3.
Dataset for: Dual O+C-band WDM transmission over 1-km hollow core NANF using an O-Band Bismuth-doped fibre amplifier (2020)

Dataset supports: Hong, Yang et al. (2020). Dual O+C-band WDM transmission over 1-km hollow core NANF using an O-Band Bismuth-doped fibre amplifier. 45th European Conference on Optical Communication (ECOC 2019)
Attenuation of Melanoma Invasion by a Secreted Variant of Activated Leukocyte Cell Adhesion Molecule (2008)

Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a marker of various cancers and mesenchymal stem cells, is involved in melanoma metastasis. We have exploited a secreted NH(2)-terminal fragment, sALCAM, to test the hypothesis that ALCAM coordinates tissue growth and cell migration. Overexpression of sALCAM in metastatic melanoma cells disturbed clustering of endogenous ALCAM and inhibited activation of matrix metalloproteinase-2 (MMP-2). Exposure of HT1080 fibrosarcoma cells to sALCAM similarly inhibited MMP-2, suggesting a broader effect on ALCAM-positive tumor cells. In contrast to the previously reported, promotive effects of an NH(2)-terminally truncated, transmembrane variant (DeltaN-ALCAM), sALCAM impaired the migratory capacity of transfected cells in vitro, reduced basement membrane penetration in reconstituted human skin equivalents, and diminished metastatic capacity in nude mice. Remarkably, L1 neuronal cell adhesion molecule (L1CAM/CD171), another progression marker of several cancers including melanoma, was suppressed upon sALCAM overexpression but was up-regulated by DeltaN-ALCAM. The partially overlapping and opposite effects induced by alternative strategies targeting ALCAM functions collectively attribute an integrative role to ALCAM in orchestrating cell adhesion, growth, invasion, and proteolysis in the tumor tissue microenvironment and disclose a therapeutic potential for sALCAM.
Anode Boosted Electrolyzer (2020)

The aim of this project is to develop an anode catalyst and anolyte delivery system in renewably powered flow-Electrolyzers that utilize waste carbon dissolved in non-potable process water as the anolyte to lower the overall cell potential at which hydrogen is generated (Anode-Boosting) while simultaneously purifying a non-potable water source. This project spans several of the desired aspects in the Renewable Hydrogen Transportation Fuel Pathways of interest: it combines renewably sourced energy with waste hydrocarbons, leading to enhanced water-splitting and eventual delivery and distribution of hydrogen for use in fuel cell powered transportation. Deployment of an Anode-Boosted Electrolysis process will provide a significant improvement in the effective energy efficiency for the generation of hydrogen due to a reduced cell potential and the desirable removal of organic impurities in waste water, offering a route to generating clean hydrogen and clean(er) water.
Covalent Binding of Heparin to Functionalized PET Materials for Improved Haemocompatibility (2015)

The hemocompatibility of vascular grafts made from poly(ethylene terephthalate) (PET) is insufficient due to the rapid adhesion and activation of blood platelets that occur upon incubation with whole blood. PET polymer was treated with NH<i><sub>x</sub></i> radicals created by passing ammonia through gaseous plasma formed by a microwave discharge, which allowed for functionalization with amino groups. X-ray photoelectron spectroscopy characterization using derivatization with 4-chlorobenzaldehyde indicated that approximately 4% of the -NH₂ groups were associated with the PET surface after treatment with the gaseous radicals. The functionalized polymers were coated with an ultra-thin layer of heparin and incubated with fresh blood. The free-hemoglobin technique, which is based on the haemolysis of erythrocytes, indicated improved hemocompatibility, which was confirmed by imaging the samples using confocal optical microscopy. A significant decrease in number of adhered platelets was observed on such samples. Proliferation of both human umbilical vein endothelial cells and human microvascular endothelial cells was enhanced on treated polymers, especially after a few hours of cell seeding. Thus, the technique represents a promising substitute for wet-chemical modification of PET materials prior to coating with heparin.
Protecting the triplet excited state in sterically congested platinum porphyrin (2013)

Platinum tetrakis(2,4,6-triethylphenyl)porphyrin (Pt-1) was synthesized and its structural (X-ray), electrochemical and photophysical properties were fully characterized. Comparative studies of Pt-1 and its unsubstituted analog PtTPP show the effect of sterically congesting ortho-substituents on the dynamics of the triplet excited states. Lowered quenching rates by 3-4 times were observed for Pt-1vs. PtTPP in the presence of oxygen and perylene, and in concentration (self)-quenching experiments.
A review of the relationship between intolerance of uncertainty and threat appraisal in anxiety (2019)

Abstract The development and conceptual relationship of the constructs of threat appraisal (TA) and intolerance of uncertainty (IU) are explored in the context of anxiety disorders. A narrative review tracking the development of these constructs and their relationship is undertaken. There is some evidence to suggest that the interaction between the components of threat appraisal (probability × cost) may partially account for or provide a theoretical framework which explains presenting levels of anxiety. Furthermore, research suggested that IU is a construct which contributes to a broad range of anxiety disorders. It was concluded that distinctive cognitive biases linked with IU – such as interpreting ambiguous and uncertain (both positive and negative) information as highly concerning – suggests that IU is interpreted negatively independent of threat appraisal. These findings mean a number of issues remain unclear, including whether IU in anxiety-provoking situations is sufficient in itself – independent of threat appraisal – in eliciting high levels of anxiety. Additionally, it is unclear whether threat appraisal and IU act as independent constructs, or more in an interactive manner in anxiety. To achieve further clarity on these issues, methodological recommendations for future research are made. Key learning aims (1) To understand the conceptual foundations of TA and IU in the cognitive model of anxiety. (2) To understand the empirical evidence supporting the role of both TA and IU in anxiety. (3) To appreciate the potential relationship between these concepts in anxiety.
Portable RBC Flumes for Furrows and Earthen Channels (1984)

ABSTRACT A new style of portable flow-measuring flume has been designed for furrows and unlined channels. These flumes are relatively easy to install and operate. Sensitivity to leveling has been decreased by placing the stilling well near the flume throat. They are long-throated flumes and require very little head loss for satisfactory operation. They are simple to construct since they consist of a short trapezoidal section with a contraction inserted in the flume bottom. Rating tables are provided for several standard sizes with capacities ranging from 1.5 to 50 L/s (0.05 to 1.8 ftVs).
Gas-phase structure and conformation of the glycosidase and ceramide glucosyltransferase inhibitor N-benzyl deoxynojirimycin (2004)

The deoxynojirimycin (DNJ) family of imino sugars are glucose analogues with an NH group replacing the oxygen atom in the pyranose ring. They are powerful inhibitors of glycosidases and ceramide glucosyltransferases. The conformation of N-benzyl-DNJ, isolated in the gas phase, is studied using a combination of resonant two-photon ionization (R2PI), UV/UV hole-burn, and IR ion-dip spectroscopies in conjunction with electronic structure theory calculations. Three distinct conformers, one major and two minor, are present and all three are assigned to structures in which the exocyclic hydroxymethyl group is axial to the piperidine ring (gauche- to the ring nitrogen). This contrasts with the preferred equatorial (gauche+) orientation observed for simple glucosides and may well contribute to the stronger binding of some enzymes to DNJ-based inhibitors compared to their natural glucoside substrates.