gebhart/patrepeval huggingface dataset:
Reliable and Flexible Quality Management Systems in the Automotive Industry: Monitor the Context and Change Effectively (2017)

Suppliers have an increasing role in the automotive industry and Quality Management Standards (QMS) are key requirements to ensure a competent supplier network, with properly selected and qualified suppliers.By surveying IRCA registered auditors concerning ISO 9001:2015 certified organizations, this research highlights the need for the automotive industry OEM and Suppliers to properly monitor the organizational (internal and external) context and identify the key issues that affect the ability of their QMS to deliver quality products, and to plan, design, implement and control change in an effective and timely manner, within the whole supply chain. (c) 2017 The Authors. Published by Elsevier B.V.
Tapering off qubits to simulate fermionic Hamiltonians (2017)

We discuss encodings of fermionic many-body systems by qubits in the presence of symmetries. Such encodings eliminate redundant degrees of freedom in a way that preserves a simple structure of the system Hamiltonian enabling quantum simulations with fewer qubits. First we consider $U(1)$ symmetry describing the particle number conservation. Using a previously known encoding based on the first quantization method a system of $M$ fermi modes with $N$ particles can be simulated on a quantum computer with $Q=N\log{(M)}$ qubits. We propose a new version of this encoding tailored to variational quantum algorithms. Also we show how to improve sparsity of the simulator Hamiltonian using orthogonal arrays. Next we consider encodings based on the second quantization method. It is shown that encodings with a given filling fraction $ν=N/M$ and a qubit-per-mode ratio $η=Q/M&lt;1$ can be constructed from efficiently decodable classical LDPC codes with the relative distance $2ν$ and the encoding rate $1-η$. A family of codes based on high-girth bipartite graphs is discussed. Graph-based encodings eliminate roughly $M/N$ qubits. Finally we consider discrete symmetries, and show how to eliminate qubits using previously known encodings, illustrating the technique for simple molecular-type Hamiltonians.
Specific proliferative response of human lymphocytes to purified soluble antigens from Plasmodium falciparum in vitro cultures and to antigens from malaria patients' sera. (1985)

Antigens of Plasmodium falciparum, in supernatants of in vitro cultures of the parasite were affinity purified on columns prepared with the IgG fraction of the serum of an immune individual. The purified antigens induced proliferation of lymphocytes from persons who had recently had malaria. The responses were strongest with lymphocytes from individuals infected with falciparum and ovale malaria; vivax malaria infections induced a lower level of response and lymphocytes of unsensitized individuals were little affected. Lymphocytes from unsensitized individuals did not respond to the affinity purified antigen preparations from malaria patients' sera indicating that significant amounts of non-specific mitogens were not present.
Cyto/Genotoxicity Study of Polyoxyethylene (20) Sorbitan Monolaurate (Tween 20) (2013)

Polyoxyethylene (20) sorbitan monolaurate (tween 20) is a non-ionic surfactant that is widely used as an emulsifier and stabilizer in pharmaceutical formulations, food and cosmetic industries. Although a number of studies have showed its non-toxic impacts on target cells, still, it is essential to investigate its effect on target cells. Therefore, in the present study, the anti-cell proliferation and cyto/genotoxicity effects of tween 20 are reported to address the possible mechanism for induction of apoptosis. At 40%-50% confluency, A549 cells and human umbilical vein endothelial cells were exposed to tween 20 at a recommended concentration for 24 h. After 24 h, to detect apoptosis and DNA damage, the treated cells were subjected to 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, fluorescein isothiocyanate (FITC)-labeled annexin V flow cytometry, DAPI staining, comet, and DNA ladder assays. Tween 20 decreased the growth of treated cells dose and time dependently, and single-strand DNA cleavage has been confirmed by comet assay. In addition, morphological alteration of DAPI-stained cells showed clear fragmentation in the chromatin and DNA rings within the nucleus of tween 20-treated cells. In addition, flow cytometry and DNA fragmentation assays confirmed DAPI staining assay results and indicated the occurrence of a programmed cell death (apoptosis) in the treated cells. These results demonstrate that, despite consideration of tween 20 as a safe non-ionic surfactant, it can induce apoptosis in target cells.
[Functioning remobilization of the paralyzed vocal cord using the split-vagus nerve procedure in rats the split-vagus nerve procedure in rats]. (2010)

The location of the recurrent laryngeal nerve fascicles in vagus provides important anatomical guideline for surgery. The split-vagus nerve procedure has a similar treatment effect compared with end-to-end nerve anastomosis. This microsurgical technique provides a new method for repairing recurrent laryngeal nerve.
Resonant laser excitation in a two-level model: a nonlinear Schrödinger equation? (1981)

A nonlinear Schrödinger equation for the dynamics of a resonantly driven two-level model including both T(1) and T(2) processes is presented. This equation is novel in that it can account both for the rate of population flow into an energy level and for the destruction of phase information, i.e., it can account for the system's evolution into a mixed quantum state.
A 2.5 to 10GHz clock multiplier unit with 0.22ps RMS jitter in a 0.18μm CMOS technology (2003)

A fully integrated clock multiplier unit uses 100mW to generate a 10GHz output clock with 0.22ps RMS jitter, exceeding the SONET OC-192 jitter generation specifications. An LC VCO is controlled by a PLL employing a fast linear phase detector in combination with a frequency detector, both running at 2.5GHz. The jitter and power dissipation are lower than that of previous CMOS implementations.
Effect of Substrate Temperature on Electrical Characteristics of (Pb, La)(Zr, Ti)O3 Ultrathin Films Deposited by Metalorganic Chemical Vapor Deposition (1995)

Lanthanum-modified lead zirconate titanate (PLZT) thin films (50-200 nm) were deposited on Pt/SiO 2 /Si substrates by metalorganic chemical vapor deposition (MOCVD). The electrical properties of the films were investigated as functions of the La content and substrate temperature. Ferroelectric PZT films were obtained at a substrate temperature as low as 500° C, and their electric characteristics were improved with increasing substrate temperature. La was adequately solid-dissolved into the PZT above 650° C. PLZT(15/45/55) films having a thickness of 100 nm were found to have good properties for application to capacitors of dynamic random access memory (DRAM), i.e., effective charge density of 80 fF/µ m 2 , dielectric constant of 1000, SiO 2 equivalent thickness of 0.4 nm and leakage current density of 5×10 -8 A/cm 2 . La addition to PZT was effective in reducing the leakage current with an increase in the registration rate.
Random Graphs with Arbitrary Degree Distribution and Their Applications (2000)

Recent work on the structure of social networks and the internet has focussed attention on graphs with distributions of vertex degree that are significantly different from the Poisson degree distributions which have been widely studied in the past. In this paper we develop in detail the theory of random graphs with arbitrary degree distributions. In addition to simple undirected, unipartite graphs, we examine the properties of directed and bipartite graphs. Among other results, we derive exact expressions for the position of the phase transition at which a giant component first forms, the mean component size, the size of the giant component if there is one, the mean number of vertices a certain distance away from a randomly chosen vertex, and the average vertex-vertex distance within a graph. We also apply our theory to some real-world graphs, including the world-wide web and collaboration graphs of scientists and business-people. We demonstrate that in some cases random graphs with appropriate distributions of vertex degree predict with surprising accuracy the behavior of the real world, while in others there is a measurable discrepancy between theory and reality, perhaps indicating the presence of additional social structure in the network which is not captured by the random graph.
A 44-year-old mentally handicapped institutionalized man with acute circulatory collapse. (1994)

A 44-year-old man with a history of hypothyroidism and seizure disorder presented to Hermann Hospital for further evaluation after being found unconscious. The patient, who was mentally handicapped and resided in a skilled nursing facility, had been in his usual state of health until the day of admission. Up to that time, he was able to perform limited self-care skills, walk and eat without assistance, and report daily to the nurse's station to receive prescribed medications. On the day of admission, he did not report as usual and was found in his room unresponsive, pale, and with cyanotic-appear- ing extremities. No peripheral pulse was palpated, and a blood pressure measurement could not be obtained. Emergency medical services (EMS) personnel arrived and immediately administered a bolus of 2.5 L normal saline; subsequently, a weak and rapid femoral pulse was appreciated, and blood pressure was measured at 110/60 mm Hg. No chest compressions were performed. ECG tracings obtained by EMS personnel were not available or reported.
EXTH-42. H3 K27M MUTANT GLIOMAS ARE SELECTIVELY KILLED BY ONC201, A SMALL MOLECULE INHIBITOR OF DOPAMINE RECEPTOR D2 (2017)

Histone H3 K27M mutations distinguish a subgroup of midline gliomas in children and young adults with devastating prognosis for which there are no effective medical therapies. In a recent phase 2 trial in adult recurrent glioblastoma with ONC201, a small molecule selective antagonist of the dopamine receptor D2 (DRD2) and D3 (DRD3), a 22 year old female with recurrent H3 K27M mutant glioblastoma had tumor regression of 92% that has persisted >15 months. Furthermore, antiseizure medication was discontinued and no ONC201 side effects were observed. Based on this exceptional response, we tested whether H3 K27M mutant gliomas were selectively sensitive to ONC201-induced apoptosis. We tested the effect of ONC201 on the cell viability of a panel of patient-derived glioma tumorsphere lines, including four H3 K27M mutant diffuse intrinsic pontine gliomas (two HIST1H3B and two H3F3A mutant), two H3F3A G34R mutant glioblastomas, and five H3 K27M/G34R wildtype (2 pediatric, 3 adult) glioblastomas. We analyzed expression of DRD2, the target of ONC201, in adult glioblastoma (n=24), pediatric H3 K27M wildtype glioblastoma (n=3) and H3 K27M mutant glioblastoma (n=8) archival tumor tissue using RNASeq. ONC201 was most potently cytotoxic to H3 K27M mutant lines (median IC50 ~0.4 uM) and had modest activity against H3 K27M/G34R wildtype lines (median IC50 ~1.2 uM), while H3 G34R lines were relatively resistant (median IC50 > 10 uM). DRD2 expression was significantly increased in H3 K27M mutant glioblastoma archival tumors relative to H3 K27M wildtype adult/pediatric gliomas. H3 K27M mutant patient-derived glioma tumorspheres appear selectively sensitive to ONC201 in vitro. Expression of DRD2 is comparatively increased in H3 K27M mutant versus wildtype gliomas. Studies to further characterize the impact of DRD2 inhibition in H3 K27M mutant glioma are ongoing, however these preliminary data indicate ONC201 may have clinical utility in H3 K27M mutant gliomas.
A DyI3-catalyzed Mannich-type Reaction of 1-Methylcyclopropanecarboxylate-type Donors for the Stereoselective Synthesis of Pyrrolidines with Quaternary Stereocenters (2008)

Abstract Stereoselective synthesis of functionalized pyrrolidines with all-carbon quaternary stereocenters is described. DyI3 catalyzed the ring opening of cyclopropanecarboxylate equivalents and promoted Mannich-type addition of the resulting α,α-disubstituted enolate intermediates to aryl and isomerizable alkyl imines, giving products in 86–58% yield and &amp;gt;96:4–84:16 diastereoselectivity.
Prolongation of the remission period and reversal of new onset type 1 diabetes with the selective elimination of autoreactive T cells (2016)

Abstract Organ-specific autoimmune diseases such as type 1 diabetes (T1D) are principally mediated by autoreactive T lymphocytes targeting self-antigens. The rapid proliferation and concomitant genomic stress that these T cells undergo during their active immune response to self-antigens affords a unique opportunity for their elimination, since these autoreactive T cells have distinct apoptotic sensitivity as a result of intrinsic DNA damage response upon activation. This sensitivity can be harnessed with a combination of p53 potentiation and cell-cycle checkpoint abrogation (PPCA), selectively eliminating these pathogenic cells while leaving naïve and regulatory T cell populations largely untouched. Using this therapy at the onset of T1D, we are able to significantly reverse new onset T1D (≥200 mg/dL blood glucose) and prolong the remission period in the Nonobese Diabetes (NOD) mouse, representing a novel therapeutic approach with significant translational potential for not only type 1 diabetes, but also other T cell-mediated autoimmune diseases.
Synthesis and high-temperature electrical conductivity of Ln2Ti2O7 and LnYTi2O7 (Ln = Dy, Ho) (2008)

Ho2Ti2O7 and LnYTi2O7 (Ln = Dy, Ho) pyrochlores have been synthesized using hydroxide coprecipitation, mechanical activation, and firing at 1600°C. The bulk and grain-boundary components of their conductivity have been determined for the first time by impedance spectroscopy. The 740°C bulk conductivity of Ho2Ti2O7 is 4 × 10−4 S/cm, and that of HoYTi2O7 is 1 × 10−3 S/cm, with activation energies E a = 1.01 and 1.17 eV, respectively, suggesting that these materials are new oxygen-ion conductors. The bulk conductivity of DyYTi2O7 (3 × 10−4 S/cm at 740°C, E a = 1.09 eV) is almost one order of magnitude lower than that of HoYTi2O7 (1 × 10−3 S/cm at 740°C, E a = 1.17 eV).
Status report on control optimization, stabilization and computer algorithms for aircraft applications. (1978)

Description based on: 22nd, Mar./Sept.1977 Edited by: Michael Athans, Alan S. Willsky, 1979/80-
Efficient pumping scheme for neodymium-doped materials by direct excitation of the upper lasing level (1999)

An efficient pumping scheme that involves direct excitation of the upper lasing level of the Nd(3+) ion is demonstrated experimentally. The results obtained for direct upper laser level pumping of Nd:YAG R2 (869 nm) and Nd:YVO(4) (880 nm) were compared with traditional approximately 808-nm pump band excitation. A tunable cw Ti:sapphire laser was used as the pump source. In Nd:YAG, the oscillator slope efficiency increased by 10% and the threshold decreased by 11%. In Nd:YVO(4), the slope efficiency increased by 5% and the threshold decreased by 11%. These results agree with theory. The increase in optical efficiency indicates that laser material thermal loading can be substantially reduced.
CuH-Catalyzed Enantioselective Intramolecular Reductive Aldol Reactions Generating Three New Contiguous Asymmetric Stereocenters (2008)

Treatment of beta,beta-disubstituted-alpha,beta-unsaturated ketones bearing a ketone residue with in situ generated, catalytic CuH ligated by a nonracemic ligand leads to three newly created adjacent chiral centers. Excellent de's and ee's are obtained for several examples studied.
Ranging Precision Analysis Of Lte Signals (2018)

Publication in the conference proceedings of EUSIPCO, Kos island, Greece, 2017
Second-Degree Interatrial Block in Hemodialysis Patients (2015)

Interatrial conduction delays manifest as a prolonged P-wave duration on surface ECG and the term interatrial block (IAB) has been coined. They are usually fixed, but cases of intermittent IAB have been described, suggesting functional conduction block at the Bachmann bundle region. We report 2 cases of patients on chronic hemodialysis therapy presenting with intermittent IAB.
ChemInform Abstract: A CHIRAL PHOSPHINE (CRC‐PHOS) DERIVED FROM (+)‐Ω‐CIEAMPHANIC ACID. A NEW LIGAND FOR HOMOGENEOUS ASYMMETRIC HYDROGENATION (1981)

Abstract Ausgehend vom Camphansäureester (Ia) wird über die Stufen (Ib) und (Ic) das chirale Phosphin (II) dargestellt, aus dem der kationische Komplex (IV) gewonnen wird.
Fluorescent in situ hybridization (FISH) assessment of chromosome copy number in sperm (1994)

Approximately 15% of all recognized pregnancies end in spontaneous abortions. The overall frequency of chromosome abnormalities in spontaneous abortions is approximately 50%. Thus aneuploidy is a significant cause of fetal wastage. In addition, structural and numerical abnormalities of chromosomes can also lead to birth defects, developmental delay, mental retardation and infertility. Conventional cytogenetic analysis via GTG- and other banding techniques is a powerful tool in the elucidation of the nature of chromosomal abnormalities. Fluorescent in situ hybridization (FISH) enables detection of numerical chromosomal abnormalities, especially trisomies, in intact cells. Using FISH and commercially available biotin-labeled probes, we have initiated a prospective study to assess specific chromosome copy number of preparations of unstained smears from men referred for a male infertility evaluation as well as smears from normal control males chosen randomly from the sample of sperm donors. A total of approximately 19,000 sperm nuclei have been examined thus far. Of those suitable for analysis, 7382 (38.75%) were normal possessing one copy of chromosome 8, 155 (0.81%) were disomic, and 15 (0.079%) had more than two copies of chromosome 8. Comparisons with data available in the literature will be discussed. Work is ongoing to increase the efficiency of hybridization using bothmore » reported and previously untried pretreatment and fixation protocols. We have also initiated studies using multicolor FISH with various chromosome enumeration probes. The assay described here is a potentially powerful tool for detecting rare events such as spontaneous germ cell aneuploidy, aneuploidy detected in semen from men with carcinoma in situ of the testis and aneuploidy induced by potential environmental genotoxicants. It can also be utilized for segregation analysis and for correlating chromosome copy number with germ cell morphology.« less
A simplified bi-state channel model for radio propagation in the Land mobile Satellite System (2009)

In this paper, a simplified channel model for land mobile satellite systems (LMSS) is proposed, which makes use of Ricean fading for the line-of-sight (LOS) scenario and composite Nakagami-m/Gamma fading for the shadowed scenario. The closed form expressions for the probability density function (pdf) and the moment generating function for the signal strength are derived. The proposed model is shown to compare favorably to existing models. Furthermore, the proposed model offers an effective and tractable technique to access performance of digital communication system for LMSS channels.
Estrogen Blocks Early T Cell Development in the Thymus (1996)

The study demonstrates that estrogen but not progesterone blocks T cell development in the thymus. However, contrary to our expectation, estrogen deprivation by oophorectomy does not enhance T cell development.
Placebo-controlled trial of hydrazine sulfate in patients with newly diagnosed non-small-cell lung cancer. (1994)

This trial failed to demonstrate any benefit for patients who received hydrazine sulfate.
Data Mining (2015)

DMIN is an international conference that serves researchers, scholars, professionals, students, and academicians who are looking to both foster working relationships and gain access to the latest research results. The 2014 Congress was composed of research presentations, keynote lectures, invited presentations, tutorials, panel discussions, and poster presentations. Selected Topics: Real-World Data Mining Applications, Challenges, and Perspectives, Classification, Clustering, Association, Web, Text, Multimedia Mining, Data Mining.
Indirect ELISA and Indirect Immunofluorescent Antibody Assay for Detecting the Antibody against Murine Norovirus S7 in Mice (2010)

To evaluate murine norovirus (MNV) infection in laboratory mice, we attempted to develop an enzyme-linked immunosorbent assay (ELISA) system and an indirect immunofluorescent antibody (IFA) assay for detecting the anti-MNV-S7 antibody in mice. MNV-S7, which was isolated in Japan, was used in both assays. The antigen for ELISA was prepared by ultracentrifugation of culture supernatants of RAW 264 cells infected with MNV-S7. Positive sera were obtained from 6-week-old, female C57BL/6JJcl mice inoculated orally with MNV-S7. IFA against infected RAW 264 cells was able to discriminate positive sera from negative sera. Indirect ELISA was performed using 96-well ELISA plates coated with formalin-treated MNV-S7 antigen. In this ELISA system, mouse sera obtained 2 weeks after infection or later showed significantly high OD values and were judged positive. An equal level of anti-MNV-S7 antibody response was observed in BALB/cAJcl, C57BL/6JJcl, DBA/2JJcl, and Jcl:ICR mice; whereas, C3H/HeJJcl mice demonstrated slightly lower antibody production 4 weeks after infection. We also used this ELISA system to evaluate 77 murine serum samples obtained from 15 conventional mouse rooms in research facilities in Japan and found that approximately half of the serum samples contained antibody to MNV-S7. We found that some serum samples were negative for antibodies to mouse hepatitis virus and Mycoplasma pulmonis but positive for antibody to MNV-S7. The results suggest that the MNV infection is more prevalent than other infections such as mouse hepatitis virus and Mycoplasma pulmonis in conventional mouse colonies in Japan, as is the case in other areas of the world.
Variable thickness shear layer aerodynamics revisited (1977)

The constant boundary-layer thickness (BLT) figuring in the Ventres (1975) Kernel function can be replaced by a slowly varying BLT, in the case of shear layers of slowly varying thickness. A simplification of the extension by Chi (1976) of Ventres' solution is put forward. The Kernel function in this instance relates pressure on the lifting surface to downwash over the surface. The results should also apply, formally, to three-dimensional compressible unsteady flows, but the accuracy in assuming slowly varying shear BLT remains to be determined. All variants of the shear layer model fail when the shear layer thickness varies rapidly.