gebhart/patrepeval huggingface dataset:
Role of the Short Telomeric Repeat Region in Marek's Disease Virus Replication, Genomic Integration, and Lymphomagenesis (2014)

Marek's disease virus (MDV) is a highly oncogenic alphaherpesvirus that infects chickens and causes high economic losses in the poultry industry. MDV integrates its genetic material into host telomeres, a process that is crucial for efficient tumor formation. The MDV genome harbors two arrays of telomeric repeats (TMR) at the ends of its linear genome that are identical to host telomeres and that are termed mTMR and sTMR. mTMR have been recently shown to be involved in MDV integration, while the functions of sTMR remain unknown. Here, we demonstrate that the presence and length of sTMR sequence, but not the exact nucleotide sequence, are crucial for MDV replication. Furthermore, the sTMR contribute to the high integration frequency of MDV and are important for MDV pathogenesis and tumor formation. As a number of herpesviruses harbor arrays of telomeric repeats (TMR), MDV serves as a model to determine the role of the herpesvirus TMR in replication, integration, and pathogenesis.
Identifying monogenic diabetes in a pediatric cohort with presumed type 1 diabetes (2014)

A high frequency of MD from mutations in GCK/HNF1α may be identified among pediatric diabetic patients originally considered to have T1D by performing genetic testing on those patients with multiple clinical risk factors for MD.
Determination of Sulfur by Combustion in Vertical Tube (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Sulfur by Combustion in Vertical TubeD. B. HagermanCite this: Anal. Chem. 1947, 19, 6, 381–383Publication Date (Print):June 24, 1947Publication History Published online1 May 2002Published inissue 24 June 1947https://pubs.acs.org/doi/10.1021/ac60006a007https://doi.org/10.1021/ac60006a007research-articleACS PublicationsRequest reuse permissionsArticle Views24Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ultra Wideband Transient Scattering and Its Applications to Automated Target Recognition (2018)

Reliable radar target recognition has long been the holy grail of electromagnetic sensors. Target recognition based on the singularity expansion method (SEM) uses a time-domain electromagnetic signature and has been well studied over the last few decades. The SEM describes the late time period of the transient target signature as a sum of damped exponentials with natural resonant frequencies (NRFs). The aspect-independent and purely target geometry and material-dependent nature of the NRF set make it an excellent feature set for target characterization. In this chapter, we aim to review the background and the state of the art of resonance-based target recognition. The theoretical framework of SEM is introduced, followed by signal processing techniques that retrieve the targetdependent NRFs embedded in the transient electromagnetic target signatures. The extinction pulse, a well-known target recognition technique, is discussed. This chapter covers recent developments in using a polarimetric signature for target recognition, as well as using NRFs for subsurface sensing applications. The chapter concludes with some highlights of the ongoing challenges in the field.
The neurobiology of pain (1999)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Comparison of pneumococcal polysaccharide and CRM197-conjugated pneumococcal oligosaccharide vaccines in young and elderly adults (1997)

Conjugation of carbohydrate antigens to protein carriers significantly improves the immune response to many carbohydrates. In order to evaluate the potential for this approach to improve the performance of pneumococcal vaccine in the elderly, we evaluated pneumococcal polysaccharide-derived oligosaccharides conjugated to cross-reacting material 197 (CRM197) (CRM-OS) in 49 older adults over 60 years of age (median age, 66 years) and compared the results to those from 50 younger adults under age 45 (median age, 27 years). Subjects were randomly assigned to receive licensed 23-valent polysaccharide vaccine (PS) which contain 25 micrograms of polysaccharide per serotype, or 5-valent CRM-OS, which contains 10 micrograms of oligosaccharide per serotype, in double-blind fashion. Both vaccines were associated with moderate local pain on administration. Antibody responses to type 14 were seen in the majority of both younger and older subjects following administration of both CRM-OS and PS, and there was no significant improvement of responses with CRM-OS in either age group. Antibody responses in young adults to the less immunogenic type 6B were seen in only 36% of subjects receiving PS and in 56% of subjects receiving CRM-OS (P = 0.15), and the geometric mean 6B titer 1 month after vaccination was higher in CRM-OS recipients (10.9 versus 3.7 micrograms/ml; P = 0.04). However, 6B responses were poor following the administration of either vaccine to elderly adults and there was no difference between results with CRM-OS and those with PS in this age group. Relatively few subjects developed measurable mucosal immunoglobulin A responses in nasal secretions following administration of either vaccine. Revaccination of CRM-OS recipients with PS at 2 months did not result in significant additional responses to 6B or 14. Though CRM-OS is possibly more immunogenic in young adults, the formulation of the pneumococcal glycoconjugate vaccine used in this study does not appear to offer an advantage to the elderly for types 6B or 14.
Organization, Ego and the Practice of Alternative Law (1972)

An increasing number of lawyers and law students are trying to work in alternative kinds of law practices. In Chicago, New York, San Francisco, Boston, groups are getting together to form law communes, legal collectives, and people's law offices. They are united in their rejection of the traditional role of the corporate lawyer and in their belief that corporate practice serves only to perpetuate the inequalities that exist in American society.\nAs more people begin to consider new forms of practice, it is important to consider some of the problems they will face in becoming "people's lawyers." The following discussion outlines some of the problems and considerations that one alternative firm had to face. Hopefully these observations and reflections on this firm will provide some idea of the practical problems involved in becoming part of an alternative venture.
Macromol. Chem. Phys. 3/2011 (2011)

Cover: Sugar sticks from polyphosphazene were synthesized by nucleophilic substitution of poly(dichlorophosphazene) with propargylamine and subsequent azide-alkyne “click” reaction of poly[di(propargylamine)phosphazene] with azdio sugar. Further details can be found in the article by X. Huang, X.-J. Huang,* A.-G. Yu, C. Wang, Z.-W. Dai, and Z.-K. Xu on page 272.
Local Electrode Atom Probes: Prospects for 3D atomic-scale metrology applications in the semiconductor and data storage industries (2001)

Recent developments in atom probe technology provide promise of a revolutionary new metrology tool that will offer information about the location and species of the atoms within the sample under investigation. Historically, atom probes have been applied mostly to needle-shaped metal specimens by a small number of experts in the world, and have been confined mostly to the research environment. This is all changing. With the developments in Scanning Atom Probes and Local Electrode Atom Probes, three-dimensional atomic-scale compositional images of almost any material may be obtained from planar specimens (wafers) by non-experts. Furthermore, the data collection rates for three-dimensional images are expected to be orders of magnitude faster than current instruments. Typical images will require hours or minutes to acquire rather than days. These developments suggest that these new atom probes can be applied to problems in the semiconductor and data storage industries on time scales that make them attractive as research tools and valuable as metrology tools.
Line edge roughness: characterization, modeling and impact on device behavior (2003)

Simple analytical expressions are presented, which calculate the impact of line edge roughness on MOSFET parameter fluctuations. It is experimentally demonstrated that LER has no impact on 80 nm gate length transistors. Simulations show LER to become significant for 32 nm channel length devices.
Dynamically reconfigurable microphone arrays (2011)

Robotic sound localization has traditionally been restricted to either on-robot microphone arrays or embedded microphones in aware environments, each of which have limitations due to their static configurations. This work overcomes the static configuration problems by using visual localization to track multiple wireless microphones in the environment with enough accuracy to combine their auditory streams in a traditional localization algorithm. In this manner, microphones can move or be moved about the environment, and still be combined with existing on-robot microphones to extend array baselines and effective listening ranges without having to re-measure inter-microphone distances.
Genotypic Variability in Some Morpho-Physiological Traits in Different Environments and Their Relationship with Cassava (Manihot esculentaCrantz) Root Yield (2020)

Cassava root yield under diverse environments is influenced by morpho-physiological traits that are in turn influenced by genotype, environment, and genotype × environment interaction (GEI). Most GEI analyses in cassava have been limited to root yield with less emphasis on stability of other yield-related traits. This study was carried out to assess the effect of GEI on some morpho-physiological traits in cassava and key traits that are useful for selection in different environments. The study utilized 20 cassava genotypes evaluated in six environments, namely, Fumesua 2013 and 2014, Nyankpala 2013 and 2014 (irrigation), and Nyankpala 2013 and 2014 (no irrigation). The genotypes were arranged in a randomized complete block design (RCBD) with three replications and assessed for a number of morpho-physiological traits, root yield and yield components. The data were subjected to analysis of variance using SAS statistical package. Subsequently, the GGE biplot was used to carry out genotype × environment, genotype × trait, and environment × trait interaction analyses to determine the specificity of genotypic performance and traits linked to particular environments. The results indicated significant (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo>&lt;</mml:mo><mml:mn>0.05</mml:mn></mml:math>) GEI effect on all traits except leaf temperature. The genotype × trait biplot analysis revealed closely related traits and those associated with root yield and genotypes that show weakness in these traits. Both environment × trait biplot and principal component analyses identified traits with higher discriminatory power among genotypes in various environments particularly in the dry environments. These can be used as secondary traits to select drought-tolerant genotypes. From this study, the GGE biplot was useful in identifying traits associated with specific genotypes in different environments to aid in selection. Moderate broad-sense heritability estimates werefound for storage root yield, harvest index, plant height, ratio of storage rootlength to girth, and cassava mosaic disease score indicating that progresscan be made through selection for these traits.
Acute Insulin Responses to Intravenous Glucose and GLP-1 are Independent of Preceding High-frequency Insulin Pulse-defects Induced by Glucose Entrainment in Healthy Humans (2005)

The objective of this study was to test the hypothesis that high-frequency oscillations in insulin release is a part of the mechanistic basis of a prompt and adequate insulin response to iv-glucose and GLP-1 exposure. In ten healthy subjects, five different insulin release patterns were induced for 360 min using computer-based glucose infusion (glucose delivered in a constant, a regular pulsatile, an irregular pulse frequency, an irregular pulse amplitude or a regular but very fast-pulsatile manner) in healthy subjects. The amount of glucose infused was identical in all five protocols (24 mg/kg/h). After 360 min, insulin secretion was assessed by means of a first-phase insulin secretion test (25 g glucose) and injection of GLP-1 (9 microg). By frequent blood sampling and analysis of insulin concentration, glucose-induced entrainment was evident in all protocols except in the constant infusion and the very fast-pulse protocol. The first-phase insulin release to glucose and GLP-1-induced insulin release were, however, comparable in the protocols. We therefore conclude from this short-term experimental setting in healthy subjects that beta-cell response to either iv-glucose or GLP-1 is independent of the preceding regularity of oscillations in insulin release.
POLYPOIDAL CHOROIDAL VASCULOPATHY FEATURES VARY ACCORDING TO SUBFOVEAL CHOROIDAL THICKNESS (2020)

Total lesion areas and polypoidal lesion areas tend to be larger in eyes with increasing SFCT. Choroidal background may influence the phenotype or progression pattern of PCV.
Original Article Mimotopic peptide immunotherapy for the treatment of multiple sclerosis, an inflammatory autoimmune disease (2013)

Several lines of evidence suggest that mast cells play a key role in the pathogenesis of Multiple Sclerosis (MS). The contribution of mast cells likely depends upon specific adherence to myelin surface-bound IgE, which trig - gers degranulation and the release of enzymes that damage central nervous system (CNS) neurons. To block mast cell degranulation, a peptide-based system was developed to neutralize endogenous, myelin-targeting autoantibod- ies, thus halting the pathological autoimmune process. Development of the MS therapeutic involved: (1) identifica - tion of relevant myelin epitopes; (2) estimation of endogenous autoantibody quantities to be neutralized; (3) syn- thesis of epitope mimicking/autoantibody-neutralizing peptides; (4) subcutaneous administration of the peptides; and (5) assessment, over time, of clinical presentation together with matching, residual autoantibody levels. An open label, interventional study was performed involving a single MS patient and five control subjects as a first step towards a potentially larger, more elaborate investigation. The study encompassed serological testing to confirm the IgE-positive status of the MS patient and negative status of the controls, an eight month course of peptide-based im- munotherapy, and assessment of therapeutic efficacy and potentially adverse effects. Treatment of the MS patient with the peptide-based therapy resulted in a reduction in myelin-specific IgE titers and marked clinical improvement. No subjects experienced adverse effects. Thus, peptide-based immunotherapy could provide improved clinical sta- tus or life-long remission to MS patients. Substantiation of this premise requires a follow-up examination by other investigators and institutions with larger and more extensive clinical trials.
New emerging correlates of weight satisfaction in women: husband -related factors and caffeine intake (2015)

Ba ckground : Weight satisfaction is an important determinant of weight-related behaviors and may result in overweight, obesity or eating disorders. To assess weight satisfaction and its related factors, including dietary intake and spouse- related factors, in adult women. M ethods : This is a descriptive-analytic cross-sectional study carried out in North of Iran. Through random sampling, 450 women aged 22-55 years under coverage of health centers were recruited from May 2012 to February 2013. Data were collected by face to face interviewing the individuals. Participants’ height, and weight and waist circumferences were recorded. Body mass index (BMI)  was calculated. We used the 24-hour recall questionnaire to estimate food intake in two days of the week. Weight satisfaction was evaluated through questioning. Multivariate logistic regression was used to determine the major factors related to weight satisfaction. Results : Weight satisfaction was 62.4% among women. About 70% of women were overweight or obese (BMI≥ 25 kg/m2). The odds of weight dissatisfaction were higher in younger, healthy individuals and those who take more caffeine on a daily basis. Moreover, the odds of weight dissatisfaction were lower in underweight/normal weight (BMI< 25 kg/m2) women and the overweight women. In addition, the rate of dissatisfaction was significantly higher in women who believed their  husbands are  dissatisfied about  their  weight and  women whose husbands were in fact dissatisfied about their weight. Conclusion : Weight satisfaction was prevalent in participants and related to age, disease status, caffeine intake, BMI and husband-related factors.
Effects of pitavastatin on atherosclerotic-associated inflammatory biomarkers in people living with HIV with dyslipidemia and receiving ritonavir-boosted atazanavir: a randomized, double-blind, crossover study (2023)

Pitavastatin treatment increases basic FGF levels, and lowers HLA-DR<sup>+</sup>CD38<sup>-</sup>CD4<sup>+</sup> T cells, and PD1<sup>+</sup>CD4<sup>+</sup> T cells. Further study on the effects of pitavastatin on preventing cardiovascular diseases in PLHIV should be pursued.
A Functional Study on CysLT<sub>1</sub> Receptors in Human Eosinophils (2002)

CysLTs induce migration and enhance degranulation in eosinophils via CysLT(1). Accordingly, interaction of CysLTs and CysLT(1) on eosinophils has the potential to play a prominent role in the pathophysiology of asthma.
A System Call Randomization Based Method for Countering Code-Injection Attacks (2009)

Code-injection attacks pose serious threat to today's Internet. The existing code-injection attack defense methods have some deficiencies on performance overhead and effectiveness. To this end, we propose a method that uses system called randomization to counter code injection attacks based on instruction set randomization idea. System calls must be used when an injected code would perform its actions. By creating randomized system calls of the target process, an attacker who does not know the key to the randomization algorithm will inject code that isn't randomized like as the target process and is invalid for the corresponding de-randomized module. The injected code would fail to execute without calling system calls correctly. Moreover, with extended complier, our method creates source code randomization during its compiling and implements binary executable files randomization by feature matching. Our experiments on built prototype show that our method can effectively counter variety code injection attacks with low-overhead.
Performance Analysis of Z-source Inverter Fed Induction Motor Drive (2012)

This paper presents performance analysis and simulation of maximum constant boost-control with third harmonic injection methods for the Z-source inverter, which can obtain maximum voltage boost for a fixed modulation index. The Z-source inverter is a recently invented a new power conversion concept mainly developed for fuel cell vehicular applications. The Z-source inverter is very advantageous over traditional inverters and it can be employed in all ac and dc power conversion applications. All traditional PWM methods can be used to control Z-source inverter. Maximum constant boost control methods eliminates the low-frequency ripples in the inductor current and capacitor voltage by maintaining the shoot-through duty cycle constant, and minimize the voltage stresses of switching devices at the same time. The Maximum boost control method is suitable for relatively high output frequency only, but in the maximum constant boost control method the Z-source network design is independent of the output frequency and determined only by the switching frequency. In this paper Z-source inverter parameters such as boost factor, output dc link voltage, capacitor voltage, output ac voltage, voltage gain etc. are determined for maximum constant boost control method for a fixed modulation index and these results are verified by simulation and experiments.
Noninvasive measurement of small-solute pulmonary microvascular permeability using a multicompartment indicator dilution-diffusion model (2002)

Measurement of pulmonary capillary permeability with small solutes in the intact organism has traditionally required multiple indicators. To enable measurement of permeability (as permeability-surface area product, PS), we developed a mathematical model based on indicator dilution and diffusion that has PS as a parameter, and which can be it to time-activity curves of a radioactively labeled small solute. Experimental validation of the technique in an experimental canine model of hydrostatic and permeability pulmonary edema resulted in PS measurements that here comparable to previously reported values, and were able to discriminate permeability pulmonary edema from normal and hydrostatic pulmonary edema.
Membranverankerung und Intervesikel-Transfer eines Derivats des Antibiotikums Moenomycin A (1999)

Die Verankerung von Moenomycin A 1 in der bakteriellen Cytoplasmamembran ist essentiell für seine antibiotische Wirksamkeit. Erste Erkenntnisse über die Stärke dieser Wechselwirkung und die Kinetik des diffusionsvermittelten Transfers zwischen Vesikeln wurden unter Verwendung eines Cumarin-markierten Moenomycin-A-Derivats durch fluoreszenzspektroskopische Methoden erhalten.
Thermal outgassing of vacuum glazing (1999)

Vacuum glazing consists of two sheets of glass separated by a narrow evacuated space. In this article we describe investigations of the causes of thermally induced degradation of vacuum glazing. It is shown that the rate of increase of pressure within the glazing during high temperature aging is mainly determined by the diffusion of water out of near-surface regions in the glass. In addition, adsorption of water molecules onto the internal surfaces influences the temperature dependence of the pressure in a degraded glazing. A prediction is made of the likely upper limit of the thermally induced degradation of vacuum glazing, and hence its properties as a thermal insulator, for a given production schedule and under conditions representative of practical applications.