gebhart/patrepeval huggingface dataset:
Analysis of an Ethylnitrosourea-generated Mouse Mutation Defines a Cell Intrinsic Role of Nuclear Factor κB2 in Regulating Circulating B Cell Numbers (2002)

The number of circulating follicular B lymphocytes is normally kept within a precise range despite their dispersion through the body and daily overproduction of precursors in the bone marrow. By establishing a genome wide recessive mutation screen in C57BL/6 mice to identify critical components of immune system regulation, we identified a mutant strain with selective deficiency in recirculating B cells but not immature or peritoneal B1 cells. Analysis of mixed bone marrow chimeras established that the mutation affects a cell autonomous process within B cells that is required for their accumulation after emigrating to peripheral lymphoid organs. The defect is caused by a point mutation in the gene encoding transcription factor nuclear factor (NF)-kappaB2, terminating the encoded protein within the DNA-binding domain. These findings establish the feasibility of analyzing immune regulation by genome wide mutant screens and demonstrates an intrinsic requirement for NF-kappaB2 in regulating circulating follicular B cell numbers.
Heat-shock protein 70 is involved in hyperbaric oxygen preconditioning on decompression sickness in rats (2013)

Decompression sickness (DCS) is a major concern in diving and space walk. Hyperbaric oxygen (HBO) preconditioning has been proved to enhance tolerance to DCS via nitric oxide. Heat-shock protein (HSP) 70 was also found to have protective effects against DCS. We hypothesized that the beneficial effects of HBO preconditioning on DCS was related to levels of elevated HSP70. HSPs (70, 27 and 90) expressed in tissues of spinal cord and lung in rats was detected at different time points following HBO exposure by Western blot. HSP27 and HSP90 showed a slight but not significant increase after HBO. HSP70 increased and reached highest at 18 h following exposure before decreasing. Then rats were exposed to HBO and subjected to simulated air dive and rapid decompression to induce DCS 18 h after HBO. The severity of DCS, along with levels of HSP70 expression, as well as the extent of oxidative and apoptotic parameters in the lung and spinal cord were compared among different groups of rats pretreated with HBO, HBO plus NG-nitro-l-arginine-methyl ester (l-NAME), HBO plus quercetin or normobaric air. HBO preconditioning significantly reduced the morbidity of DCS (from 66.7% to 36.7%), reduced levels of oxidation (malondialdehyde, 8-hydroxyguanine and hydrogen peroxide) and apoptosis (caspase-3 and -9 activities and the number of apoptotic cells). l-NAME or quercetin eliminated most of the beneficial effects of HBO on DCS, and counteracted the stimulation of HSP70 by HBO. Bubbles in pulmonary artery were detected using ultrasound imaging to observe the possible effect of HBO preconditioning on DCS bubble formation. The amounts of bubbles in rats pretreated with HBO or air showed no difference. These results suggest that HSP70 was involved in the beneficial effects of HBO on DCS in rats, suspected be by the antioxidation and antiapoptosis effects.
ChemInform Abstract: REGIO‐ AND STEREOSELECTIVE RING OPENING OF EPOXY ALCOHOLS WITH ORGANOALUMINUM COMPOUNDS LEADING TO 1,2‐DIOLS (1983)

Abstract Die Spaltung des Epoxides (I) mit Trimethylaluminium (II) zum Diol (III) wird untersucht.
B Cell Phenotype-dependent Expression of the Epstein-Barr Virus Nuclear Antigens EBNA-2 to EBNA-6: Studies with Somatic Cell Hybrids (1991)

The expression of the transformation-associated Epstein-Barr virus (EBV)-encoded nuclear antigens (EBNAs) 1 to 6 and membrane protein LMP-1 was studied in a series of somatic cell hybrids derived from the fusion of the EBV-transformed lymphoblastoid cell line (LCL) KR-4, and the EBV-carrying Burkitt’s lymphoma lines Daudi, P3HR-1 and Raji, with non-B cell lines of fibroblast, erythroid, myeloid and epithelial origin. Expression of EBNAs 2 to 6 was down-regulated in the hybrids in parallel with extinction of the B cell markers CD19, CD20, CD21, CD23, HLA class II, and surface or cytoplasmic immunoglobulin. LMP-1 was expressed independently of EBNA-2 in hybrids derived by the fusion of the LMP-1-positive KR-4 and P3HR-1 cell lines with epithelial and myeloid cells, respectively. LMP-1 was down-regulated in hybrids derived by the fusion of P3HR-1 with an erythroid cell line and in the hybrid between Raji and a mouse fibrosarcoma line. EBNA-1 was the only EBV antigen that was regularly expressed in the hybrids regardless of the dominating cellular phenotype. The autonomous expression of EBNA-1 suggests that its regulatory pathway is independent of phenotype-associated cellular or viral factors. In contrast, the expression of EBNAs 2 to 6 appears to require a B cell environment. EBNA-2 was shown to contribute to the regulation of LMP expression in B cells. We show that in LCL-carcinoma hybrids the dominating epithelial phenotype is permissive for LMP expression in the absence of EBNA-2.
Effectiveness of Purging in an Air-Conditioned Office Building in Singapore (2003)

AbstractThis paper investigates the effectiveness of a Purging System in a high-rise office building in Singapore with the aim of improving indoor air quality. The study initially adopts a continuous monitoring concept to investigate the impact of a daily purging operation on pollutant concentration levels at the low, middle and high floors of the office building. Pollutants investigated include formaldehyde, carbon dioxide, carbon monoxide and total volatile organic compounds (TVOC). This is then followed by purging experiments using sulphur hexafluoride in three different configurations to obtain various ventilation parameters. Finally, Computational Fluid Dynamics (CFD) simulations using FLUENT software are used to corroborate the results. It is shown that purging is effective in reducing indoor TVOC and carbon dioxide concentration, and should be executed at times when the lowest carbon monoxide concentration is registered outdoors. The minimum duration of purging is observed to be 12 minutes, even with a purging fan having a capacity of six air-change-per-hour.Key words:: indoor air qualitysick building syndromepurging systemcontinuous monitoringcomputational fluid dynamicsFLUENT
Processing-Related Issues for the Design and Lifing of SiC/SiC Hot-Section Components (2006)

For successful SiC/SiC engine components, numerous process steps related to the fiber, fiber architecture, interphase coating, and matrix need to be optimized. Under recent NASA-sponsored programs, it was determined that many of these steps in their initial approach were inadequate, resulting in less than optimum thermostructural and life properties for the as-fabricated components. This presentation will briefly review many of these process issues, the key composite properties they degrade, their underlying mechanisms, and current process remedies developed by NASA and others.
Three-Dimensional Diffusion Theory Analysis of the Power Burst Facility (2014)

shown i n Figure 1.The core and test space a r e enclosed i n a water- , -.d f i l l e d v e s s e l approximately 4.57 m (15 f t ) i n diameter and 8.84 m (29 f t ) deep.Active core height is 0.9144 m (3 f t ) .The PBF can ''?operate i n e i t h e r a t r a n s i e n t o r steady-state mode, driving nuclear 'fuel elements located i n t h e c e n t r a l space t o destructive power densities without damaging t h e d r i v e r core.Reactivity is controlled by " .?eight movable control rods and four movable t r a n s i e n t rods, i n t e r -+ -" L _ _ spersed among the c y l i n d r i c a l f u e l rods.Core cooling and neutron .-.:moderation a r e provided by demineralized water c i r c u l a t e d through and,around the core.Drives t h a t position and move t h e control rods and ' t r a n s i e n t rods a r e mounted on a control bridge above the reactor vessel.
Infrared spectroscopic study of the interactions of cations in zeolites with simple molecular probes. Part 2.—Adsorption and polarization of molecular hydrogen on zeolites containing polyvalent cations (1992)

Cationic forms of different zeolites have been studied by diffuse reflectance infrared spectroscopy using low-temperature adsorption of molecular hydrogen as a probe. The frequency of the stretching vibrations of the H—H bond was found to be strongly dependent on the charge of the cations. For alkaline-earth-metal forms of high-silica zeolites the frequency shifts correlated with the polarizing ability (e/r) of the cations. The influence of different factors (hydrolysis of cations and their localization) on hydrogen polarization is also discussed.
Magnetic survey of the San Gabriel Wash (1944)

As a partial fulfillment of the requirements in obtaining a degree of Master of Science in Geological Sciences at the California Institute of Technology, the writer was given the task of writing a thesis on the following subject: “Magnetic Survey and interpretation of the results over the San Gabriel wash.” The area is between Monrovia and Azusa, two miles west of Azusa. It is accessible by several roads branching from Foothill Boulevard (U.S. Highway 66) running east and west, passing through Monrovia and Azusa. One of them is the Las Lomas Road going north along the west bank; the other one is an oiled road going to the Cyanide Company plant and continuing as a dirt road along the east bank. The upper part of the wash and the canyon itself can be reached by the State Highway 39 running northward from Azusa. From this road several dirt roads branch out. The wash is too large to make a detailed survey in a short time. Thus, the work done is more or less a reconnaissance survey. It is surrounded by farms, the Cyanide Company plant, private properties and impenetrable jungle-like areas, so that it has not been possible to take readings anywhere. Another disadvantage is that the running water is controlled by the dam, and sometimes it cannot be crossed, due to abundance and speed of water. Big granite boulders covering the whole wash constitute still another disadvantage, making tripod setting very difficult. The work was carried on under the directions of Dr. G.W. Potapenko, Associate Professor of Physics, whose assistance is gratefully acknowledged by the writer.
Repair and reorganization of minced cardiac muscle in the adult newt (Notophthalmus viridescens) (1978)

Abstract Studies of the response of adult mammalian and amphibian ventricle to injury have indicated the formation of a connective tissue scar in the place of the wounded or amputated muscle. It has been demonstrated that amphibian myocytes adjacent to a wound surface, unlike mammalian myocytes, have a proliferative capacity. In the present study, a minced cardiac muscle graft was placed into the adult newt ventricle in order to increase the number of myocytes near a wound surface. With such an increased number of reactive myocytes, it was thought a new wall consisting primarily of muscle might be formed. One‐sixteenth to one‐eighth of the ventricular apex was removed, minced and returned to the amputation surface of the ventricle. General histological and autoradiographic studies were conducted on two sham‐operated animals and on five experimental animals which were killed at 5, 10, 20, 30, 50 and 70 days after surgery. Major events of the repair and reorganization of minced cardiac muscle included blood clot formation followed by necrosis of the blood clot and much of the muscle graft. By ten days, an apparent coalescence of muscle fragments and continuity of ventricular and graft lumina were observed, although the graft area never formed an integrated unit with the wounded ventricular wall. The peak of mitotic activity (3.19%) and thymidine labeling (28.1%) of graft cells, including many cells which resembled cardiac myocytes, was observed at 20 days. At 30 days, the graft was observed as a continuous wall composed primarily of muscle fibers. Several 30‐, 50‐ and 70‐day grafts had rhythmic contractions. These results suggest that amphibian cardiac muscle has histogenetic and proliferative capacities not attributable to mammalian cardiac muscle.
Optimal Training Data Selection for Rule-Based Data Cleansing Models (2011)

Enterprises today accumulate huge quantities of data which is often noisy and unstructured in nature making data cleansing an important task. Data cleansing refers to standardizing data from different sources to a common format so that data can be better utilized. Most of the enterprise data cleansing models are rule based involving lot of manual effort. Writing data quality rules is tedious task and often results in creation of erroneous rules because of the ambiguities that the data presents. A robust data cleansing model should be capable of handling a wide variety of records which is often dependant on the choice of the sample records knowledge engineer uses to write the rules. In this paper we present a method to select a diverse set of data records which when used to create the rule based data cleansing model can cover the maximum number of records. We also present a similarity metric between two records which help in choosing the diverse set of data samples. We also present a crowd sourcing based labeling mechanism to label the diverse records selected by the system so that collective intelligence of crowd can be used to eliminate the errors that occur in labeling sample data. We also present a method to select difficult set of diverse examples so that the crowd and the rule writer services can be effectively utilized to create a better cleansing model. We also present a method selection of such records for updating an existing rule set. We present the experimental results to show the effectiveness of the proposed methods. Results demonstrate an increase of 12% in the number of rules written, using this procedure. We also show that the method identifies records on which the existing model yields lower accuracy than on the records identified by other techniques, and thus identifies records that are more difficult to cleanse for the existing model.
Fast and secure distributed read-only file system (2002)

Internet users increasingly rely on publicly available data for everything from software installation to investment decisions. Unfortunately, the vast majority of public content on the Internet comes with no integrity or authenticity guarantees. This paper presents the self-certifying read-only file system, a content distribution system providing secure, scalable access to public, read-only data.The read-only file system makes the security of published content independent from that of the distribution infrastructure. In a secure area (perhaps off-line), a publisher creates a digitally signed database out of a file system's contents. The publisher then replicates the database on untrusted content-distribution servers, allowing for high availability.The read-only file system avoids performing any cryptographic operations on servers and keeps the overhead of cryptography low on clients, allowing servers to scale to a large number of clients. Measurements of an implementation show that an individual server running on a 550-Mhz Pentium III with FreeBSD can support 1,012 connections per second and 300 concurrent clients compiling a large software package.
The Charcot Foot (2013)

Charcot joint is an uncommon but often missed complication of the neuropathic diabetic foot. Prompt recognition and treatment with plantar pressure redistribution can prevent unnecessary amputation.
Harnessing Hafnium‐Based Nanomaterials for Cancer Diagnosis and Therapy (Small 32/2023) (2023)

Hafnium-Based Nanomaterials The clinical translation of hafnium oxide for cancer radiotherapy has aroused extensive interest on Hf-based nanomaterials for biomedical application. In article number 2300341, Gan Tian, Wenyan Yin, and co-workers comprehensively summarize the recent advances in synthesis, computed tomography (CT)-involved diagnosis and radiotherapy-related synergistic cancer therapy of Hf-based nanomaterials. More efforts will be invested in these promising Hf-based nanomedicines as clinical candidates in the future.
The outcomes of glucose abnormalities in pre‐diabetic chronic hepatitis C patients receiving peginterferon plus ribavirin therapy (2012)

Successful eradication of HCV improves glucose abnormalities in pre-diabetic CHC patients.
Low copy number vectors for expression of fused genes to Î²-galactosidase inEscherichia coli (1991)

A series of six expression vectors, pXM184Lac.A, B, C, pXM184Z.A, B, C, based on the low copy plasmid pACYC184 that allow for expression of proteins fused to beta-galactosidase in Escherichia coli is described. A level of 50,000 units of beta-galactosidase is routinely observed and is easily identifiable on protein gels. This paper also reports the tight regulation of expression of the Trc promoter in these vectors using the LacIq repressor.
Wireless communications engineering education via Augmented Reality (2016)

The widespread adoption of wireless devices in all aspects of the public's daily lives and the growing demand for professionals in the wireless communications field demonstrate the need for in-depth wireless engineering education. This increased demand triggered many academic institutions to start offering courses and programs in this area. As a part of our previous work, we provided a platform for students to keep up with the improvements in the wireless communications field and gain hands-on experience using Software Defined Radios (SDR). However, existing coursework and curricula in wireless networking is challenged by the fact that it is difficult to intuitively visualize how the nodes in the network are operating in a way that is linked to the everyday world. In this paper, we introduce visualizations of wireless lab exercises using an Augmented Reality (AR) mobile app. The AR app is designed and built for a wide selection of wireless communications courses, where we are able to visualize links between wireless nodes, antenna radiation patterns, and data throughput. In this paper, we experimentally assess and present the benefits of introducing AR-based visualization tools into wireless communications courses at both the undergraduate and graduate level in terms of student interest and change in skill level.
Synthesis and Structure Resolution of RbLaF4 (2012)

The synthesis and structure resolution of RbLaF(4) are described. RbLaF(4) is synthesized by solid-state reaction between RbF and LaF(3) at 425 °C under a nonoxidizing atmosphere. Its crystal structure has been resolved by combining neutron and synchrotron powder diffraction data refinements (Pnma,a = 6.46281(2) Å, b = 3.86498(1) Å, c = 16.17629(4) Å, Z = 4). One-dimensional (87)Rb, (139)La, and (19)F MAS NMR spectra have been recorded and are in agreement with the proposed structural model. Assignment of the (19)F resonances is performed on the basis of both (19)F-(139)La J-coupling multiplet patterns observed in a heteronuclear DQ-filtered J-resolved spectrum and (19)F-(87)Rb HMQC MAS experiments. DFT calculations of both the (19)F isotropic chemical shieldings and the (87)Rb, (139)La electric field gradient tensors using the GIPAW and PAW methods implemented in the CASTEP code are in good agreement with the experimental values and support the proposed structural model. Finally, the conductivity of RbLaF(4) and luminescence properties of Eu-doped LaRbF(4) are investigated.
Relationship between biological activity and dipole moment in benzo[a]phenothiazines. (1998)

Relationship between the biological activity and two different dipole moments were investigated in 9 benzo[a]phenothiazines [1-8] by calculating the dipole moment with the PM3 method. 12H-Benzo[a]phenothiazine [1], 9-methyl-12H-benzo[a]phenothiazine [2], 10-methyl-12H-benzo[a]phenothiazine[3] and 11-methyl-12H-benzo[a]phenothiazine [4] induced monocytic differentiation of human myelogenous leukemic cell lines and displayed antitumor activity. These active compounds showed a significantly smaller value of calculated ground-state dipole moment (mu g) and larger value of first excited-state dipole moment (mu e). The mu e/mu g ratio of four active compounds [1-4] ranged from 3.25 to 4.38, whereas that of three inactive compounds [5,6,7] ranged from 1.77 to 2.72. These two different dipole moments might be useful parameters for estimation of the biological activity of benzo[a]phenothiazines [1-8].
The Competent Manager: A Model for Effective Performance (1982)

Competence and Job Performance. The Research Design and Methods. The Goal and Action Management Cluster. The Leadership Cluster. The Human Resource Management Cluster. The Directing Subordinates Cluster. The Focus on Others Cluster. Specialized Knowledge. An Integrated Competency Model. Interpretation by Sector and Managerial Level. Summary and Implications. Appendixes. Index. Figures.
Characterization of electron transport at high fields in silicon-on-insulator devices: a Monte Carlo study (2005)

The high field transport regime of single gate (SG) SOI MOSFETs has been the subject of an in-depth characterization. To study this, we have used a Monte Carlo simulator where all the major features involved in the description of the transport of state-of-the-art SOI devices are taken into account: quantization, non-parabolic band structure, phonon and surface roughness scattering. It has been shown that the behaviour of stationary electron velocity curves versus the longitudinal electric field is different to what we found in standard bulk devices. Particularly, it is very interesting that different saturation velocity values show up in the simulations. We found different curves corresponding to different effective fields when both phonon and surface roughness scattering mechanisms are taken into consideration. In addition, it was observed that the electron velocity obtained was dependent on the silicon layer thickness even when the same effective field was taken into account. Clear dependence of the saturation velocity has also been depicted in the delta parameter (representing the abrupt variations of the oxide-semiconductor surface) used in the surface roughness scattering model. Finally, we have performed simulations on double gate (DG) MOSFETs and observed different saturation velocities when we change the thickness of the intrinsic silicon slab.
Influence ofGlomus intraradiceson Black Foot Disease Caused byCylindrocarpon macrodidymumonVitis rupestrisUnder Controlled Conditions (2006)

We examined the influence of an arbuscular-mycorrhizal fungus, Glomus intraradices (INVAM CA 501), on black foot disease caused by the fungus Cylindrocarpon macrodidymum on Vitis rupestris cv. St. George under controlled conditions. Mycorrhizal or nonmycorrhizal grape rootings were inoculated with the pathogen. Eight months following inoculation with the pathogen, we evaluated disease severity, vine growth, and mycorrhizal colonization. Mycorrhizal plants developed significantly less leaf and root symptoms than nonmycorrhizal plants (P = 0.04 and P < 0.0001, respectively). Only nonmycorrhizal grape rootings inoculated with the pathogen had significantly less dry root and leaf weights compared with the noninoculated control (P = 0.0021 and P = 0.0017, respectively). Mycorrhizal colonization was high (48.3% for the noninfected control and 54.5% for plants infected with C. macrodidymum) and not significantly affected by inoculation with C. macrodidymum (P = 0.2256). Thus, V. rupestris preinoculated with G. intraradices were less susceptible to black foot disease than nonmycorrhizal plants. Results from this study suggest that preplant applications of G. intraradices may help prevent black foot disease in the nursery and in the vineyard.