gebhart/patrepeval huggingface dataset:
t→cV via SUSY FCNC couplings in the unconstrained MSSM (2004)

We recalculate the branching ratios for t→cV (V=g,γ,Z) induced by SUSY FCNC couplings within the general unconstrained MSSM framework using mass eigenstate approach. Our results show that the branching ratios for these decays are larger than ones reported in previous literatures in the MSSM with R-parity conservation, and they can reach ∼10−4, ∼10−6, and ∼10−6, respectively, for favorable parameter values allowing by current precise experiments. Thus, the branching ratios for t→cg and t→cγ may be measurable at the LHC.
The Cr-Fe (Chromium-Iron) System (1981)

51.996 amu Chromium and bcc iron dissolve in all proportions from Cr to Fe. The ~ and 8 allotropes of Fe unite at over 12 wt.% Cr to form a continuous bcc solid solution, ~SFe, stable at all temperatures up to the solidus. Consequently, the range of the fcc ~-phase is restricted. The element Cr is a stabilizer for a~Fe but not ~Fe.
Personalized Medicine: Progress and Promise (2011)

Personalized medicine is a broad and rapidly advancing field of health care that is informed by each person's unique clinical, genetic, genomic, and environmental information. Personalized medicine depends on multidisciplinary health care teams and integrated technologies (e.g., clinical decision support) to utilize our molecular understanding of disease in order to optimize preventive health care strategies. Human genome information now allows providers to create optimized care plans at every stage of a disease, shifting the focus from reactive to preventive health care. The further integration of personalized medicine into the clinical workflow requires overcoming several barriers in education, accessibility, regulation, and reimbursement. This review focuses on providing a comprehensive understanding of personalized medicine, from scientific discovery at the laboratory bench to integration of these novel ways of understanding human biology at the bedside.
Antidiabetic potential of polyoxotungstates: in vitro and in vivo studies (2014)

Diabetes mellitus is a chronic metabolic disorder continuously affecting people all over the world. A common way to treat diabetes mellitus is to limit the conversion of carbohydrates into glucose which is mediated by glucosidase enzymes. Diabetes mellitus is also famous for its life-threatening microvascular (retinopathy, neuropathy and nephropathy) and macrovascular (atherosclerosis) complications. Aldose reductases present in eye lens (ALR1) and kidney (ALR2) are responsible for microvascular complications. The production of advanced glycation end products (AGEs) is involved in the development of atherosclerosis. The present work was aimed at the synthesis and in vitro/in vivo evaluation of different polyoxotungstates against glucosidases (α- and β), aldose reductases (ALR1 and ALR2) and AGEs to discover a new treatment which may limit the complications associated with diabetes mellitus. The polyanion [P6W18O79](20-) was found to be the most potent inhibitor of α-glucosidase (IC50 = 1.33 ± 0.41 μM), ALR1 (IC50 = 0.4 ± 0.009 μM) and ALR2 (IC50 = 0.38 ± 0.02 μM). Animal studies showed that the polyanion [H2W12O40](6-) was very effective in reducing the blood glucose level to 84.25 ± 5.07 mg dL(-1) when compared with standard antidiabetic drug glibenclamide (150.62 ± 9.35 mg dL(-1)) measured after maximum 8 h of dose administration. The data obtained from in vitro and in vivo experiments confirm that [P6W18O79](20-) and [H2W12O40](6-) could be used as a new treatment of diabetes mellitus.
Selective Loss of α Motoneurons Innervating the Medial Gastrocnemius Muscle in a Mouse Model of Amyotrophic Lateral Sclerosis (1998)

Mutations in the superoxide dismutase gene 1 (SOD-1) are found in patients with familial amyotrophic lateral sclerosis (FALS). Overexpression of a mutated human SOD-1 gene in mice results in neurodegenerative disease as result of motoneuron loss in lumbar spinal cord (10). Using this mouse model of FALS, we have established a quantitative assay utilizing the retrograde tracer Fluorogold (FG) to determine the number of motoneurons innervating one skeletal muscle in mice with ongoing disease. In adult wild-type mice, the number of alpha motoneurons retrogradely labeled by an injection of FG into medial gastrocnemius muscle is 50 +/- 7 and this number remains constant from 7 to 18 weeks of age. In mutant mice, the number of alpha motoneurons retrogradely labeled by FG is the same as in wild-type mice at 7 and 9 weeks, but then declines to 36% of that in normal mice at 18 weeks. This decline also correlates positively to severity of motor impairments in these mice as assessed by the hindlimb splay test. In contrast, the number of FG-labeled gamma motoneurons remains relatively unchanged in both wild-type and mutant mice up to 18 weeks. At 18 weeks of age, this apparent alpha motoneuron denervation is paralleled by an average of 55% reduction of MG-muscle mass and 40% weaker performance in the hindlimb splay test. These data suggest that alpha motoneurons are the most vulnerable neuronal subtype in this mouse model of ALS and it is primarily their loss that leads to functional motor deficits. This quantitative bioassay also will be valuable for evaluating novel therapeutics for ALS.
Design of anisotropic metamaterials via optical transformation (2009)

In the past two years, much attention has been paid to the optical transformation, which is based on the metric invariance property of Maxwell's equations. The transformation optics opens up many possibilities and approaches to control and guide the electromagnetic (EM) waves and can be employed to design anisotropic metamaterials. In this talk, we will present the recent progress we have made on this area.
Enhanced absorbance of a strained nanoscale Si-layered system (2003)

Si modifications implemented at the nanoscale lead to optoelectronic and photovoltaic effects that can widen applications of conventional Si devices. The investigation exploits charge carrier and photon flux transformations at a so-called carrier collection limit. Comparison of the collection efficiencies of the same sample with and without a buried nanosystem allows a better understanding of the optical (absorbance) and electronic (carrier collection) behaviors. Experimental evidence for enhanced absorbance of a strained nanoscale Si-layered system has been found.
Near-Infrared Observations of Isophotal Twists in Barred Spiral Galaxies (1996)

We present observations in JHK passbands for 12 barred galaxies and in BI passbands for 9 galaxies in order to study isophotal twists in early- and late-type barred spirals. We also summarize previous observations and examine high-resolution atlas images to compile data on twists as a function of Hubble type. Twists have been detected only in early-type spirals. This result is consistent with the hypothesis that only early- type bars have inner Lindblad resonances and that twists are associated with ILRs. The transition occurs around type SBbc and parallels the transition from bars with relatively flat intensity profiles to bars with exponential profiles in later types.
<title>Evaluation of the ultraviolet/ozone technique for on-orbit removal of photolyzed molecular contamination from optical surfaces</title> (1992)

Molecular species outgassed from spacecraft materials adhere tenaciously to and darken spacecraft surfaces when exposed to solar ultraviolet (UV) radiation. Such deposits severely degrade the performance of optical systems operating at UV and visible wavelengths. Data is presented which demonstrates the feasibility of a UV/Ozone cleaning technique in removing such deposits in a space-compatible configuration without damage to the optical surface. The technique involves the UV irradiation of the optical surface in the presence of low pressure molecular oxygen, resulting in the photolytic formation of ozone (O<SUB>3</SUB>) and subsequent photochemical removal of the contamination.
Enhanced differentiation of embryonic stem cells using co‐cultivation with hepatocytes (2008)

We examined the effects of co-cultivated hepatocytes on the hepatospecific differentiation of murine embryonic stem (ES) cells. Utilizing an established mouse ES cell line expressing high or low levels of E-cadherin, that we have previously shown to be responsive to hepatotrophic growth factor stimulation (Dasgupta et al., 2005. Biotechnol Bioeng 92(3):257-266), we compared co-cultures of cadherin-expressing ES (CE-ES) cells with cultured rat hepatocytes, allowing for either paracrine interactions (indirect co-cultures) or both juxtacrine and paracrine interactions (direct co-cultures, random and patterned). Hepatospecific differentiation of ES cells was evaluated in terms of hepatic-like cuboidal morphology, heightened gene expression of late maturation marker, glucose-6-phosphatase in relation to early marker, alpha-fetoprotein (AFP), and the intracellular localization of albumin. Hepatocytes co-cultured with growth factor primed CE-ES cells markedly enhanced ES cell differentiation toward the hepatic lineage, an effect that was reversed through E-cadherin blockage and inhibited in control ES cells with reduced cadherin expression. Comparison of single ES cell cultures versus co-cultures show that direct contact co-cultures of hepatocytes and CE-ES cells maximally promoted ES cell commitment towards hepatodifferentiation, suggesting cooperative effects of cadherin-based juxtacrine and paracrine interactions. In contrast, E-cadherin deficient mouse ES (CD-ES) cells co-cultured with hepatocytes failed to show increased G6P expression, confirming the role of E-cadherin expression. To establish whether albumin expression in CE-ES cells was spatially regulated by co-cultured hepatocytes, we co-cultivated CE-ES cells around micropatterned, pre-differentiated rat hepatocytes. Albumin localization was enhanced "globally" within CE-ES cell colonies and was inhibited through E-cadherin antibody blockage in all but an interfacial band of ES cells. Thus, stem cell based cadherin presentation may be an effective tool to induce hepatotrophic differentiation by leveraging both distal/paracrine and contact/juxtacrine interactions with primary cells of the liver.
Application of Markov Decision Processes to pipeline data (2010)

TRANSP-OR
Catalysis by the Tumor-Suppressor Enzymes PTEN and PTEN-L (2015)

Phosphatase and tensin homologue deleted from chromosome ten (PTEN) is a lipid phosphatase tumor suppressor that is lost or inactivated in most human tumors. The enzyme catalyzes the hydrolysis of phosphatidylinositol-(3,4,5)-trisphosphate (PIP3) to form phosphatidylinositol-(4,5)-bisphosphate (PIP2) and inorganic phosphate. Here, we report on the first continuous assay for the catalytic activity of PTEN. Using this assay, we demonstrate that human PTEN is activated by the reaction product PIP2, as well as in solutions of low salt concentration. This activation is abrogated in the K13A variant, which has a disruption in a putative binding site for PIP2. We also demonstrate that PTEN-L, which derives from alternative translation of the PTEN mRNA, is activated constitutively. These findings have implications for catalysis by PTEN in physiological environments and could expedite the development of PTEN-based chemotherapeutic agents.
Nutrient Requirements of Poultry (1994)

Nutrient requirements of poultry , Nutrient requirements of poultry , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
The Primordial Inflation Explorer (PIXIE) Mission (2010)

The Primordial Inflation Explorer (PIXIE) is an Explorer-class mission to map the absolute intensity and linear polarization of the cosmic microwave background and diffuse astrophysical foregrounds over the full sky from frequencies 30 GHz to 6 THz (1 cm to 50 &mu;m wavelength). PIXIE uses a polarizing Michelson interferometer with 2.7 K optics to measure the difference spectrum between two orthogonal linear polarizations from two co-aligned beams. Either input can view either the sky or a temperature-controlled absolute reference blackbody calibrator. The multimoded optics and high etendu provide sensitivity comparable to kilo-pixel focal plane arrays, but with greatly expanded frequency coverage while using only 4 detectors total. PIXIE builds on the highly successful COBE/FIRAS design by adding large-area polarization-sensitive detectors whose fully symmetric optics are maintained in thermal equilibrium with the CMB. The highly symmetric nulled design provides redundant rejection of major sources of systematic uncertainty. The principal science goal is the detection and characterization of linear polarization from an inflationary epoch in the early universe, with tensor-to-scalar ratio r &lt;&lt; 10<sup>-3</sup>. PIXIE will also return a rich data set constraining physical processes ranging from Big Bang cosmology, reionization, and large-scale structure to the local interstellar medium.
Apprentissage statistique et regularisation pour la regression (1997)

Le sujet de cette these est l'etude et l'utilisation de l'apprentissage statistique et de la regularisation sur des problemes de regression. On s'interesse plus particulierement a l'identification de systemes et a la modelisation de series temporelles par des modeles lineaires d'une part et connexionnistes non-lineaires d'autre part. Les regressions parametriques lineaires et non-lineaire sont brievement presentees, et les limites de la regression simple sont illustrees en utilisant le concept d'erreur de generalisation. Ainsi definis, ces problemes sont incorrectement poses, et necessitent donc l'utilisation de regularisation pour obtenir des solutions correctes. Ceci introduit un ou plusieurs hyper-parametres qui controlent le niveau de regularisation et dont l'optimisation est effectuee en estimant l'erreur de generalisation. Plusieurs methodes sont presentees a cet effet. Ces developpements sont utilises pour s'attaquer a deux problemes particuliers. Dans le premier, il s'agit de determination des entrees necessaires a la modelisation d'une serie temporelle, par l'intermediaire d'une methode iterative s'appuyant sur l'estimation de la generalisation. Dans le second, on etudie une fonctionnelle de regularisation particuliere qui present l'interet d'effectuer un elagage des parametres inutiles du modele en conjonction avec son effet regularisant. Cette derniere partie utilise des estimateurs bayesiens qui sont aussi presentes de facon generale dans la these.
Reversible C–H Activation in Zirconaaziridine Species: Characterization and Bonding of a Bridging (Amino)alkylidene Complex Active in Alkyne Hydroaminoalkylation (2022)

Efforts to synthesize a low-coordinate zirconaaziridine complex supported by a bis(ureate) ligand resulted in the formation of bridging aminoalkylidene 2. Complex 2 is a rare example of an aminoalkylidene complex featuring a μ(η2:η2)-N,C binding mode. This complex was fully characterized by single-crystal X-ray diffraction, NMR spectroscopy, and LIFDI-MS. Analysis of the natural localized molecular orbitals (NLMOs) showed a σ-bonding interaction between the alkylidene carbon and each zirconium center with significant delocalization of the Zr1–C1 σ bond into Zr2, thereby explaining the significant differences in the Zr–C bond lengths observed in the solid state. A solution-phase equilibrium between complex 2 and the putative zirconaaziridine species was supported by evaluating the reactivity of 2 in alkyne hydroaminoalkylation. The reaction of diphenylacetylene with complex 2 produced a five-membered metallacycle product, a key intermediate in alkyne hydroaminoalkylation. This reaction was greatly accelerated in the presence of pyridine, suggesting that the presence of neutral donors is essential to favor the formation of reactive zirconaaziridine complexes. In addition, the catalytic activity of complex 2 in the benchmark hydroaminoalkylation reaction of diphenylacetylene with N-benzylaniline was established.
Hormonal control of the biosynthesis of hamster oviductin (1995)

In several mammalian species, the epithelial secretory cells of the oviduct synthesize and secrete specific glycoproteins that become associated with the zona pellucida of the ovulated oocyte. These glycoproteins are collectively designated as oviductins. A monoclonal antibody directed against hamster oviductin was used to study the ontogeny of this glycoprotein. Indirect immunofluorescence experiments performed on sections of hamster oviduct revealed that the glycoprotein begins to be secreted in 10-day-old females and that all of the oviductal secretory cells showed fluorescent staining by day 14. The intensity of the immunofluorescence reaction reached a maximum in the 28-day-old females. The oviducts of the 7-day-old hamster incorporated [35S]methionine in vitro into several proteins; however, the production and secretion of detectable amounts of radiolabeled oviductin only began at 14 days of age and reached a maximum at day 28 of age. It appears that the ontogeny of oviductin parallels the hormone dependent changes leading to sexual maturation and that its maximum secretion is already established at the time of the first ovulatory cycle. These results are substantiated by the fact that the production of oviductin is induced in estradiol-treated, but not progesterone or non-treated prepubertal animals, as determined by indirect immunofluorescence experiments.
Validation of Measures to Improve Rail Vehicle Crashworthiness (1996)

The authors describe development work in the area of crashworthiness of railway vehicles carried out during a four year period in the UK. Specific areas of investigation include vehicle overriding and the collision behaviour of complete trains or rakes of vehicles. Developments in crashworthiness by European railways are also discussed.
Cloning, characterization and expression of the Zymononas mobilis eda gene that encodes 2‐keto‐3‐deoxy‐6‐phosphogluconate aldolase of the Entner‐Doudoroff pathway (1991)

The eda gene that encodes 2-keto-3-deoxy-6-phosphogluconate aldolase of the Entner-Doudoroff pathway was cloned from Zymomonas mobilis by genetic complementation of an Escherichia coli mutant. The gene is present in a single copy on the Z. mobilis genome and is not tightly linked to the edd gene. Nucleotide sequence analysis of the eda region revealed that the structural gene is 627 bp long and capable of encoding a protein of 208 amino acids with a deduced molecular weight of 21,505. The eda gene is monocistronic and is transcribed from a single promoter. The transcriptional initiation site was determined and an improved consensus promoter sequence for Z. mobilis was derived. High-level expression of the eda gene can be attributed to very efficient translational initiation caused by the high quality of the ribosome-binding site and stability of the mRNA, which has a decay rate of 7.6 min. A comparison of highly expressed Z. mobilis genes indicated that the relative quality of the ribosome-binding sites of these genes might play an important role in determining the level of enzyme synthesis. This possibility is discussed with regard to the role of gene expression in co-ordinating the enzyme levels of the Entner-Doudoroff glycolytic pathway.
TAN: a packet switched network for VLSI testing (2004)

In this paper, we introduce the idea of using packet switched network as the mode of communication between automatic test equipment and the VLSI chip under test in a multisite ATE architecture. We show that our architecture, which we refer to as test area network reduces the complexity and time involved in testing tens of chips at a time. To increase the ATE utilization, we distribute a portion of ATE's task of signature verification to the intelligent test-heads, which are now capable of applying patterns and verifying signatures produced by the chip being tested. Our analysis and empirical results indicate a speed up of 4 to 10 by using existing network infrastructure.
Epigenome-wide meta-analysis of DNA methylation and childhood asthma (2019)

Background: Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. Objective: We sought to identify differential DNA methylation in newborns and children related to childhood asthma. Methods: Within the Pregnancy And Childhood Epigenetics consortium, we performed epigenome-wide meta-analyses of school-age asthma in relation to CpG methylation (Illumina450K) in blood measured either in newborns, in prospective analyses, or cross-sectionally in school-aged children. We also identified differentially methylated regions. Results: In newborns (8 cohorts, 668 cases), 9 CpGs (and 35 regions) were differentially methylated (epigenome-wide significance, false discovery rate &lt; 0.05) in relation to asthma development. In a cross-sectional meta-analysis of asthma and methylation in children (9 cohorts, 631 cases), we identified 179 CpGs (false discovery rate &lt; 0.05) and 36 differentially methylated regions. In replication studies of methylation in other tissues, most of the 179 CpGs discovered in blood replicated, despite smaller sample sizes, in studies of nasal respiratory epithelium or eosinophils. Pathway analyses highlighted enrichment for asthma-relevant immune processes and overlap in pathways enriched both in newborns and children. Gene expression correlated with methylation at most loci. Functional annotation supports a regulatory effect on gene expression at many asthma-associated CpGs. Several implicated genes are targets for approved or experimental drugs, including IL5RA and KCNH2. Conclusion: Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age. Cross-sectional associations in children can reflect both risk for and effects of disease. Asthma-related differential methylation in blood in children was substantially replicated in eosinophils and respiratory epithelium.
PREOPERATIVE USE OF STATIN AND INSULIN RESISTANCE IN CARDIAC SURGERY (2011)

Non-diabetic hypercholesterolemic patients scheduled for elective coronary artery bypass graft surgery were included in the study. Patients who were on lipophilic statin therapy (atorvastatin, rosuvastatin) were allocated to the statin group. Hypercholesterolemic patients who were not previously treated with lipophilic statin were allocated to the control group.
Application of statistical process control to the software process (1992)

Article Free Access Share on Application of statistical process control to the software process Author: Mark A. Lantzy BTG, Inc., 1945 Old Gallows Road, Vienna, Virginia BTG, Inc., 1945 Old Gallows Road, Vienna, VirginiaView Profile Authors Info & Claims WADAS '92: Proceedings of the ninth Washington Ada symposium on Ada: Empowering software users and developersJuly 1992 Pages 113–123https://doi.org/10.1145/257683.257717Online:16 July 1992Publication History 13citation1,001DownloadsMetricsTotal Citations13Total Downloads1,001Last 12 Months10Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF