gebhart/patrepeval huggingface dataset:
Presence of Oxidized Cholesterol in Caveolae Uncouples Active Platelet-derived Growth Factor Receptors from Tyrosine Kinase Substrates (2000)

Platelet-derived growth factor receptor beta (PDGFRbeta) in fibroblasts is concentrated in caveolae where it controls the tyrosine phosphorylation of multiple proteins. Caveolae are enriched in cholesterol and sphingolipids, but the role of these lipids in PDGFR signal transduction is unknown. We report that introduction of cholest-4-en-3-one into caveolae membranes uncouples PDGFR autophosphorylation from tyrosine phosphorylation of neighboring proteins. Cholest-4-en-3-one appears to interfere with the normal interaction between PDGFR and its partners. The results suggest that tightly packed caveolae lipids form a membrane platform that functions as a lipid scaffold for organizing the molecular interactions of multiple signaling pathways.
Water monitoring system for oil contamination using polymer-coated quartz crystal microbalance chemical sensor (2002)

A water monitoring system with a new chemical sensor for oil contamination was developed. The sensor had an organic polymer film on a quartz crystal microbalance (QCM). The organic film was a hydrocarbon polymer and had high affinities for the organic compounds of petroleum products such as gasoline, kerosene, diesel oil and fuel oil. The monitoring system as composed of a sampling part, a purging part, a humidity control part and a sensor part. The oil in contaminated river water could be detected whose threshold odour number (TON) was less than three. The detecting time was less than 5 min depending on the oil kindness. This system was tested using artificially contaminated river water with the oils, to be found that the sensitivity was kept steady for longer than 6 months with 400 detections of diesel oil and heavy oil. Moreover, the oil kind could be discriminated with only one sensor device by analyzing the desorption response curves obtained by flowing a clean air on the sensor instead of the purging air.
Computational analysis of genome-scale growth-interaction data in Saccharomyces cerevisiae (2014)

University of Minnesota Ph.D. dissertation. August 2014. Major: Computer Science. Advisor: Chad L. Myers. 1 computer file (PDF); xiii, 216 pages, appendices A-B.
Production of 40TBq tritium using neutron-irradiated 6Li-Al alloy. (1988)

A facility was reconstructed for producing tritium in 40 TBq per batch. Gaseous tritium was extracted from neutron-irradiated 6Li-Al alloy targets by heating at 700°C under vacuum and collected in uranium. The recovery yield of tritium was about 100% and the isotopic purity of the product was about 95%. Through the production run, no leakage of tritium from the facility was observed.
A CASE OF HORSESHOE LEIOMYOMA AT THE ESOPHAGOGASTRIC JUNCTION REMOVED BY LAPAROSCOPY-ASSISTED SURGERY (2007)

症例は42歳, 男性. 平成12年に検診にて食道胃接合部の粘膜下腫瘍を指摘され, 経過観察を行っていたが, 平成16年10月の検査で腫瘍の増大を認めたため手術目的にて当科に紹介された. 超音波内視鏡ガイド下穿刺吸引生検にて平滑筋腫と診断されたため, 腹腔鏡下に腫瘍核出術を行った. 術中にS-Bチューブを挿入し, 胃用バルーンにて牽引することで初めて腫瘍が確認され, 食道胃接合部の半周に7cm長の馬蹄形で存在していた. 摘出後, His角の筋層が欠損したため, これを縫合修復し, さらに食道胃接合部左側のみに噴門形成術を追加した. 術後経過良好であり術後消化管造影検査にても通過障害や逆流を認めていない. 食道胃接合部に発生する馬蹄型平滑筋腫は腹腔鏡下手術の良い適応である. 食道胃接合部は逆流防止機構として重要な役割を担っているため, 腫瘍摘出後には噴門形成術を付加するのが良いと考えられた.
User study of emotional visualization dashboard for educational software: Description of the study protocol (2018)

This paper describes a user study plan for the MADE Teacher’s Dashboard, our proposed data visualization dashboard that supports educators to inspect and reflect on the emotional states of students using web learning applications. Our goal was to support the system designer, and indirectly also teachers and students. Our dashboard follows affective learning models and monitors online learner emotions. It uses an open source library that supports tracking of facial features and detection of emotions in real time, identifying six different emotions. We present a user study plan to determine whether the data visualization graph can be interpreted properly.
N‐Formylation of Amines via the Aerobic Oxidation of Methanol over Supported Gold Nanoparticles (2009)

Dress code: formyl. Gold nanoparticles supported on NiO catalyze the one-pot N-formylation of amines with methanol and molecular oxygen to produce formamide at a selectivity of 90 %. This process generates methyl formate in situ, followed by reaction with amines.
Novel Fast Color-Converter for Visible Light Communication Using a Blend of Conjugated Polymers (2015)

Visible Light Communications (VLC) is a promising new technology which could offer higher data transmission rates than existing broadband RF/microwave wireless technologies. In this paper, we show that a blend of semiconducting polymers can be used to make a broadband, balanced color converter with a very high modulation bandwidth to replace commercial phosphors in hybrid LEDs for visible light communications. The resulting color converter exploits partial Förster energy transfer in a blend of the highly fluorescent green emitter BBEHP-PPV and orange-red emitting MEH-PPV. We quantify the efficiency of the photoinduced energy transfer from BBEHP-PPV to MEH-PPV, and demonstrate modulation bandwidths (electrical-electrical) of ∼200 MHz, which are 40 times higher than commercially available phosphor LEDs. Furthermore, the VLC data rate achieved with this blend using On–Off Keying (OOK) is many times (∼35) higher than that measured with a commercially available phosphor color converter.
Synthesis and Physical Properties of Choline Carboxylate Ionic Liquids (2012)

A series of choline carboxylate ionic liquids (ILs) have been synthesized by neutralization of choline hydroxide solution with acetic, propanoic, butanoic, pivalic, and hexanoic acids. The salts so obtained were characterized by NMR spectroscopy, thermal methods, and elemental analysis. Key physical properties (density, viscosity, and refractive index) were measured for the propanoate, butanoate, and hexanoate salts at temperatures from (293.15 to 353.15) K. The densities were used to estimate the molecular volumes, standard entropies, crystal lattice energies, and thermal expansion coefficients. All five choline carboxylates were found to have cytotoxicities (IC50 values) above 10 mM toward the human breast cancer cell line, MCF-7, indicating they are much less toxic than common imidazolium-based ILs.
Defining Species-Specific Immunodominant B Cell Epitopes for Molecular Serology of Chlamydia Species (2015)

Urgently needed species-specific enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies against Chlamydia spp. have been elusive due to high cross-reactivity of chlamydial antigens. To identify Chlamydia species-specific B cell epitopes for such assays, we ranked the potential epitopes of immunodominant chlamydial proteins that are polymorphic among all Chlamydia species. High-scoring peptides were synthesized with N-terminal biotin, followed by a serine-glycine-serine-glycine spacer, immobilized onto streptavidin-coated microtiter plates, and tested with mono-specific mouse hyperimmune sera against each Chlamydia species in chemiluminescent ELISAs. For each of nine Chlamydia species, three to nine dominant polymorphic B cell epitope regions were identified on OmpA, CT618, PmpD, IncA, CT529, CT442, IncG, Omp2, TarP, and IncE proteins. Peptides corresponding to 16- to 40-amino-acid species-specific sequences of these epitopes reacted highly and with absolute specificity with homologous, but not heterologous, Chlamydia monospecies-specific sera. Host-independent reactivity of such epitopes was confirmed by testing of six C. pecorum-specific peptides from five proteins with C. pecorum-reactive sera from cattle, the natural host of C. pecorum. The probability of cross-reactivity of peptide antigens from closely related chlamydial species or strains correlated with percent sequence identity and declined to zero at <50% sequence identity. Thus, phylograms of B cell epitope regions predict the specificity of peptide antigens for rational use in the genus-, species-, or serovar-specific molecular serology of Chlamydia spp. We anticipate that these peptide antigens will improve chlamydial serology by providing easily accessible assays to nonspecialist laboratories. Our approach also lends itself to the identification of relevant epitopes of other microbial pathogens.
IMARI: multi-Interventional program for prevention and early Management of Anastomotic leakage after low anterior resection in Rectal cancer patIents: rationale and study protocol (2020)

Trialregister.nl ( NL8261 ), January 2020.
Cerebral Vascular Mean Transit Time in Healthy Humans: A Comparative Study with PET and Dynamic Susceptibility Contrast-Enhanced MRI (2006)

Cerebral vascular mean transit time (MTT), defined as the ratio of cerebral blood volume to cerebral blood flow (CBV/CBF), is a valuable indicator of the cerebral circulation. Positron emission tomography (PET) and dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) are useful for the quantitative determination of MTT in the clinical setting. The aim of this study was to establish a normal value set of MTT as determined by PET and by DSC-MRI and to identify differences between these methods. Seven healthy volunteers were studied with (15)O-PET (H(2)(15)O and C(15)O) and gradient-echo echo-planar DSC-MRI at 1.5 T. In the DSC-MRI study with bolus injection of contrast agent, deconvolution analysis was performed. Comparison of gray-to-white matter ratios showed fairly good agreement between PET and DSC-MRI for all parameters (relative CBV, relative CBF, and relative MTT), confirming the validity of relative measurements with DSC-MRI. However, quantitative MTT measured by DSC-MRI was significantly shorter than that measured by PET in cerebral cortical regions (2.8 to 3.0 secs for DSC-MRI versus 3.9 to 4.3 secs for PET) and the centrum semiovale (3.5 secs for DSC-MRI versus 4.8 secs for PET). These discrepancies may be because of the differences in the intrinsic sensitivity of each imaging modality to vascular components; whereas PET measurement of CBV is equally sensitive to all vascular components, measurement with DSC-MRI originates from the microvasculature in the vicinity of the brain parenchyma. This underlying difference may influence interpretation of MTT determined by PET or by DSC-MRI for patients with cerebrovascular disease.
PT047 Effects of short-term exercise training on the plasma lipids, lipid transfer to HDL and cytokine levels in patients with heart failure (2014)

Hypoxemia increases corrected QT dispersion (QTcD), which is the difference between the maximum and minimum QT intervals and is a strong risk factor for cardiovascular mortality. The aim of this study was to investigate the QTcD in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS), and the relationship between the QTcD and 123I-metaiodo-benzylguanidine (MIBG) cardiac imaging, which reflects cardiac sympathetic activity.A university hospital.Forty-eight OSAHS patients without cardiac diseases (mean [± SD] age, 45.9 ± 10.8 years; apnea-hypopnea index [AHI] 51.9 ± 18.5 events per hour) who underwent polysomnography before treatment and on the first night of nasal continuous positive airway pressure (nCPAP) treatment.Before and after nCPAP treatment was started, we measured the QTcD with computer software, before, during, and after sleep, as well as the washout rate of the MIBG administered for cardiac imaging. As a control, QTcD was also measured in the morning from 26 healthy subjects.Before treatment, the mean QTcD during sleep (65.0 ± 14.6 ms) was greater than that before sleep (57.0 ± 13.5 ms; p < 0.0001). Meanwhile, after 1 night of nCPAP therapy, the QTcD during sleep (50.6 ± 11.4 ms) decreased from that before treatment (p < 0.0001) and was smaller than the QTcD before sleep (56.2 ± 13.3 ms; p = 0.003). Before treatment, the QTcD during sleep correlated with the AHI (r = 0.38; p = 0.009) and the percentage of time that Sao2 was < 90% (Sao2 < 90% time) [r = 0.34; p = 0.018]. The QTcD did not correlate with the body mass index or the washout rate of MIBG. However, the washout rate of MIBG correlated with the AHI and the Sao2 < 90% time.Nocturnal QTcD is increased in OSAHS patients but is decreased by nCPAP therapy independently of cardiac sympathetic function.
Enhancement of charge transport in methylammonium lead halide thin films via solvent vapor annealing (Conference Presentation) (2018)

In hybrid halide perovskite, the effectiveness of charge transport in relation to film microstructure and processing has remained elusive. In this study we succeeded in tuning grain size and grain boundary chemistry through solvent vapor annealing, which resulted in an increase in charge-carrier mobility by one order of magnitude. To understand the mechanism responsible for the enhanced charge transport, we performed a series of complementary measurements. Atomic force microscopy revealed an increase in grain size and uniformity, and optical microscopy showed a macroscopic reorganization of the film structure. X-ray diffraction measurements of the MAPbI3-xClx films confirmed the removal of preferential orientation after 20 min of solvent annealing at room temperature, in N,N-dimethylformamide. The presence of additional peaks was assigned to the formation of the solvent complex MAI:DMF:PbI2 and the PbI2:DMF ligand, and the content of these phases was monitored as a function of annealing time. Charge-carrier mobility was evaluated from field-effect transistor measurements in devices with gold top contacts and SiO2 bottom-gate dielectric. We obtained ambipolar transport, with both hole and electron mobility exceeding 10cm2/Vs at room temperature. We propose that this remarkable enhancement in electrical properties resulted from an increase in the grain size and passivation of grain boundaries via formation of intermediate solvent complexes formed from unreacted material. This work has allowed us to gain unprecedented insight into the impact of film morphology on charge transport in perovskite materials, an important milestone towards achieving high-performance optoelectronic devices such as transistors, photovoltaics, light emitting diodes, and photodetectors.
Electronic and Nonlinear Optical Materials:  The Role of Theory and Modeling (2000)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTElectronic and Nonlinear Optical Materials: The Role of Theory and ModelingShashi P. KarnaView Author Information Air Force Research Laboratory, Space Vehicles Directorate, 3550 Aberdeen Avenue, Southeast, Kirtland Air Force Base, New Mexico 87117-5776Cite this: J. Phys. Chem. A 2000, 104, 20, 4671–4673Publication Date (Web):May 2, 2000Publication History Published online2 May 2000Published inissue 1 May 2000https://pubs.acs.org/doi/10.1021/jp001296yhttps://doi.org/10.1021/jp001296yeditorialACS PublicationsCopyright © 2000 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views750Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (22 KB) Get e-AlertscloseSUBJECTS:Defects,Materials,Molecular electronics,Nonlinear optics,Theoretical models Get e-Alerts
Mo-ZrO2Solid Acid Catalyst For Transesterification of β-Ketoesters (1999)

Abstract An efficient and mild method for transesterification of β-ketoester catalyzed by Mo-Z1O2 solid acid catalyst is described.
Novel dipeptide aldehydes are proteasome inhibitors and block the MHC-I antigen-processing pathway (1995)

Class I MHC (MHC-I) molecules present peptides derived from Ag that are processed in the cytosol. The proteasome is a multicatalytic protease complex that is present in the cytosol and has been implicated in cytosolic Ag processing. Novel dipeptide aldehydes were designed, synthesized, and demonstrated to specifically inhibit the chymotrypsin-like protease activity of isolated proteasomes, but produced relatively little inhibition of cathepsin B, a vacuolar cysteine protease. The inhibitors were membrane permeable and inhibited intracellular cleavage of a membrane-permeable fluorogenic substrate of the chymotrypsin-like proteasome activity. When a model Ag, OVA, was introduced into the cytoplasm of M12.B6 murine B cells by electroporation, the proteasome inhibitors blocked its processing for subsequent presentation by MHC-I molecules. The inhibitors had little effect on class II MHC processing of exogenous Ag. The potencies of different inhibitors for blockade of MHC-I Ag processing correlated directly with their potencies for inhibition of the chymotrypsin-like proteasome activity. In contrast, conventional inhibitors of vacuolar cysteine proteases (e.g., leupeptin and benzyloxycarbonyl-Phe-Ala-CHN2) had little effect on MHC-I processing or the chymotryspin-like activity of isolated proteasomes. These results directly demonstrate that inhibition of proteasome activity blocks MHC-I Ag processing, confirming a role for proteasomes in this pathway. Moreover, they suggest that the chymotrypsin-like activity of the proteasome may be of major importance to the cytosolic processing of at least some Ag.
Synthesis, Characterization, and Stereocomplex-Induced Gelation of Block Copolymers Prepared by Ring-Opening Polymerization of l(d)-Lactide in the Presence of Poly(ethylene glycol) (2003)

A series of block copolymers were synthesized by ring-opening polymerization of l(d)-lactide in the presence of mono- or dihydroxyl poly(ethylene glycol) (PEG) using zinc metal as a catalyst. The resulting diblock and triblock copolymers with relatively short polylactide (PLA) blocks were characterized by various analytical techniques such as 1H NMR, SEC, DSC, and X-ray diffraction. The data showed that the copolymers were semicrystalline materials with predominant PEG crystallization although PLA blocks crystallized slightly in some cases. Solubilization tests showed that both the composition and molar mass are determining factors in the water solubility of the copolymers. Bioresorbable hydrogels were prepared from aqueous solutions containing both poly(l-lactide)/PEG and poly(d-lactide)/PEG block copolymers. Hydrogel formation resulted from stereocomplexation occurring between poly(l-lactide) and poly(d-lactide) blocks.
Evaluation of lithography simulation model accuracy for hotspot-based mask quality assurance (2007)

Mask topography has effects on important components of optical image formation at 45nm node and beyond, and therefore, the lithography simulation model required for hotspot-based mask quality assurance has to incorporate mask topography effects. Since calculation of mask topography effects involves physical phenomena different from those encountered in resist processes, we propose the concept of the mask & resist dual fitting method that splits the general experimental model into the experimental resist model and the experimental mask model. To realize mask & resist dual fitting, we have developed an experimental mask model, namely, the mask topography approximate model. The mask & resist dual fitting method can improve model fitting accuracy and improve prediction accuracy at hotspots.
Instantaneous Axes of Rotation of the Lumbar Intervertebral Joints (1988)

Lateral radiographs of ten normal individuals were studied to determine the location of the instantaneous axis of rotation (IAR) of every lumbar vertebra for the movements of flexion and extension from the upright position and flexion from the fully extended position; and errors involved in the technique were quantified to establish confidence limits for the results of the calculations. The distribution of the IARs was found to fall within a small range from the mean location at each level, particularly for the movement of flexion from the extended position. Within-observer and between-observer errors occurred in tracing and superimposing radiographs and marking x and y coordinates. Unacceptably large errors occur when the movement of the joint is less than 5 degrees, and only the IAR for flexion from extension can be plotted with acceptable confidence. This result invalidates the notion that plotting centrodes may be of diagnostic value in recognizing mechanical disorders. The determination of a single extension to flexion IAR may be of more value clinically, to which end this study provides essential normative data.
Abstract IA22: Single cell proteomics to capture human dysplasia and dysfunction (2020)

Abstract Single cell analysis, starting with the earliest low parameter fluorescent cytometry and microscopy experiments, helped define the major cell subsets of human cellular systems as we understand them today. Now, a novel combination of elemental mass spectrometry with single cell analysis (mass cytometry – CyTOF, Science 2011) and imaging (multiplexed ionbeam imaging – MIBI, Nature Med. 2014, Cell 2018) offers routine examination of &amp;gt;50 parameters without fluorescent agents or interference from spectral overlap using heavy metal isotopes as reporters. With these platforms, we have reached new levels of organizational understanding in human pathobiology. Here, we will review the evolution of these technologies and present our latest efforts to create assays with these platforms in order to quantify multiple levels of regulation including metabolism, proteome dynamics, and chromatin content regulating the epigenome. Further to this, we will highlight recent efforts to leverage structural characteristics of leukemia dysplasias to facilitate automated identification and classification from multiplexed single cell datasets (Tsai &amp; Glass et al. Nature Med. 2020). Overall, these new approaches can reveal new layers of human cellular organization and structure that can be exploited to understand dysfunction in general and provide avenues for more automated and robust clinical classification. Citation Format: Sean Bendall. Single cell proteomics to capture human dysplasia and dysfunction [abstract]. In: Proceedings of the AACR Virtual Special Conference on Tumor Heterogeneity: From Single Cells to Clinical Impact; 2020 Sep 17-18. Philadelphia (PA): AACR; Cancer Res 2020;80(21 Suppl):Abstract nr IA22.
Appendix C: List of Abbreviations (2017)

Diagnostic Algorithms for Common GI Symptoms 2ND Edition This page contains the DOI reference links for the online version of the Rome IV book, volumes I and II. If you have a Rome Online subscription and are logged in,