gebhart/patrepeval huggingface dataset:
Widely tunable polarization-stable fiber lasers (1995)

Four different widely tunable polarization-stable lasers, each based on nonpolarization maintaining erbium-doped fiber are presented. We experimentally examine the effect of output coupling on laser performance, and compare the output power measurements with theoretical predictions. We also discuss the relative costs and construction factors of the four lasers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Bone Morphogenetic Protein 2 Signaling Mediator Smad1 Participates Predominantly in Osteogenic and not in Chondrogenic Differentiation in Mesenchymal Progenitors C3H10T½ (2000)

The role of the bone morphogenetic protein (BMP)-signaling mediator Smad1 in osteogenic or chondrogenic differentiation was investigated in murine parental mesenchymal progenitors C3H10T1/2 and its derivatives constitutively expressing BMP-2 (C3H10T1/2-BMP-2) and, therefore, undergo BMP-mediated osteogenic/ chondrogenic development. The functions of the three Smad1 domains, that is, the N-terminal (MH1) domain, the C-terminal (MH2) domain, and the midregional proline-rich linker domain, were documented and compared with full-length Smadl. We showed that expression of the MH2 domain in parental C3H10T1/2 cells was sufficient to initiate osteogenic differentiation. Interestingly, MH1 was sufficient to initiate transcription of osteogenic marker genes like the osteocalcin or parathyroid hormone/parathyroid hormone-related protein (PTH/PTHrP) receptor. However, MH1 interfered with the histologically distinct formation of osteoblast-like cells. A dominant-negative effect on MH2-mediated osteogenic development in C3H10T1/2 cells was observed by the dose-dependent trans-expression of the midregional linker domain. Importantly, in contrast to osteogenic differentiation, Smad1 and its domains do not mimic or interfere with BMP-2-dependent chondrogenic development as monitored by the inability of MH2 to give rise to histologically distinct chondrocytes in parental C3H10T1/2 cells and by the inefficiency of the MH1 or linker domain to interfere with BMP-2-mediated chondrogenic differentiation.
Parallele Bewegungsplanung in dynamischen Umgebungen (1997)

Dieser interne Bericht gibt einen Ueberblick ueber die aktuellen Forschungsergebnisse aus dem gleichnamigen Projekt. Hierbei wird das Problem der praktikablen Bewegungsplanung fuer Industrieroboter in dynamischen Umgebungen angegangen. Der Grundalgorithmus ohne wesentliche off-line Berechnungen basiert auf der A*-Suche und arbeitet im impliziten, diskretisierten Konfigurationsraum. Die Kollisionen werden im kartesischen Arbeitsraum durch hierarchische Abstandsberechnung im gegebenen CAD-Modell erkannt. Eine zyklische Aufteilung des Suchraums auf die einzelnen Prozessoren ermoeglicht eine gut skalierbare Parallelverarbeitung fuer nachrichten-gekoppelte Rechnersysteme. Die Leistungsfaehigkeit des Bewegungsplaners wird an einem Satz von Benchmark-Problemen validiert. Unterstuetzt durch eine optimale Diskretisierung zeigt der neuartige Ansatz einen linearen Speedup. Fuer Umgebungen mit unbewegten Hindernissen liegen die Laufzeiten im Sekundenbereich. Zur weiteren Beschleunigung der Bewegungsplanung wird erstmalig eine heuristische hierarchische Suche im impliziten Konfigurationsraum eingefuehrt. Fuer zweidimensionale Benchmark-Probleme ergibt die Hierarchisierung eine starke Reduktion des Suchaufwandes.
Infectious complications in transfused patients after radical cystectomy. (2016)

This analysis provides strong observational evidence that PBT is associated with an increased risk of perioperative infectious complications, which may be secondary to transfusion-related immunomodulation. Urologists should aggressively pursue blood conservation strategies and adhere to evidence-based restrictive transfusion thresholds, particularly given the rising rate of PBT.
Coarse-grained strain dynamics and backwards/forwards dispersion (2006)

A Particle Tracking Velocimetry experiment has been performed in a turbulent flow at intermediate Reynolds number. We present experimentally obtained stretching rates for particle pairs in the inertial range. When compensated by a characteristic time scale for coarse-grained strain we observe constant stretching. This indicates that the process of material line stretching taking place in the viscous subrange has its counterpart in the inertial subrange. We investigate both forwards and backwards dispersion. We find a faster backwards stretching and relate it to the problem of relative dispersion and its time asymmetry.
The Predicted ABC Transporter AbcEDCBA Is Required for Type IV Secretion System Expression and Lysosomal Evasion by Brucella ovis (2014)

Brucella ovis is a major cause of reproductive failure in rams and it is one of the few well-described Brucella species that is not zoonotic. Previous work showed that a B. ovis mutant lacking a species-specific ABC transporter (ΔabcBA) was attenuated in mice and was unable to survive in macrophages. The aim of this study was to evaluate the role of this ABC transporter during intracellular survival of B. ovis. In HeLa cells, B. ovis WT was able to survive and replicate at later time point (48 hpi), whereas an ΔabcBA mutant was attenuated at 24 hpi. The reduced survival of the ΔabcBA mutant was associated with a decreased ability to exclude the lysosomal marker LAMP1 from its vacuolar membrane, suggesting a failure to establish a replicative niche. The ΔabcBA mutant showed a reduced abundance of the Type IV secretion system (T4SS) proteins VirB8 and VirB11 in both rich and acid media, when compared to WT B. ovis. However, mRNA levels of virB1, virB8, hutC, and vjbR were similar in both strains. These results support the notion that the ABC transporter encoded by abcEDCBA or its transported substrate acts at a post-transcriptional level to promote the optimal expression of the B. ovis T4SS within infected host cells.
Techno-economic analysis of thermal power generation in a system with high levels of non-dispatchable renewable energy (2008)

Cyclic operation of base thermal plant in the recently liberalized Irish all-island electricity market is set to increase with the expansion of variable renewable (principally wind) generation. This paper examines the effects of this change of operational regime for existing conventional generation plant.
Water-driven programmable polyurethane shape memory polymer: Demonstration and mechanism (2005)

We demonstrate the new features of a polyurethane shape memory polymer: water-driven actuation and recovery in sequence (i.e., programmable). Hydrogen bonding is identified as the reason behind these features. In addition, the absorbed water is quantitatively separated into two parts, namely, the free water and bound water. Their individual contribution on the glass transition temperature is identified.
Cell-specific upregulation of lung “cancer signature genes” in the small airway epithelium of asymptomatic smokers. (2019)

3109 Background: Most lung cancers are derived from the small airway (6 th -23 rd generations) epithelium (SAE). While a pathogenic mutation in a driver gene is critical to transform a SAE cell to a malignant cell, single cell analysis of lung cancers has demonstrated that individual cancer cells have transcriptional alterations in many “cancer signature genes” (Lambrechts D et al, Nature Med 2018; 24:1277) that are not driver genes, but likely support the malignant state. Based on the concept that dysregulation of many of these genes facilitate the malignant state, we hypothesized that, with the stress of smoking, some of these cancer-supporting transcriptional modifications occur long before the random hit with a driver mutation, providing a soil for the driver mutation. Methods: To assess this hypothesis, we applied drop-seq single cell transcriptome analysis to assess SAE recovered by fiberoptic bronchoscopy and brushing of n = 3 healthy non-smokers and n = 3 healthy smokers. Using unsupervised clustering, 11 cell types were identified including major SAE cell types (basal, intermediate, club, mucous and ciliated), rare epithelial cells (ionocyte, neuroendocrine and undefined NCL hi ) and rare immune/inflammatory cell (Tcell, mast, antigen presenting). Results: Comparison of smokers and nonsmokers showed that smoking significantly altered the transcriptome (n = 426 genes upregulated, n = 572 genes downregulated) in different SAE cell types; 21% -56% of smoking-upregulated genes in the major SAE cell population are identified as “cancer signature genes”, where a number have cell-specific smoking regulated patterns within individual cell types including HSPB1 in mucous cells, ADH7 in ciliated, LAMB3 in basal and intermediate cells, MIF intermediate and club cells, ALDH3A1 in all main SAE cell types. Conclusions: These data support the concept that cigarette smoking, long before the development of cancer, reprograms specific SAE cells to provide the biological soil to support driver genes to function.
Commentary on “Hemodynamic Management of Acute Spinal Cord Injury” (2021)

The review article by Lee et al. 1 addresses a topic of significant importance in the extensively multifaceted management of patients suffering from acute spinal cord injuries (SCIs). It has been almost three decades since the term secondary injury was recognized as the most crucial pathophysiological process influencing clinical outcomes in the postinjury period. 2 Ischemia due to compromised spinal cord perfusion was shown to be one of the major components of the secondary injury cascade. This finding led to one of the most essential components of acute SCI management, in that adequate spinal cord perfusion shall be maintained through avoidance of systemic hypotension and support of mean arterial pressure (MAP).
Mind the Semantic Gap: Policy Intent Inference from Network Metadata (2021)

Network Policy management is a tedious and laborious task because of scale and dynamic changes in the network. The advent of Softwarized Networks has led to a renewed interest in intent-based network policy management. Intent-based Networking provides a structured way of specifying the intent of policies which are automatically translated and compiled into network device configuration. While this top-down approach of policy intent to policy configuration has worked well for cloud-native infrastructures such as data centers, it has not seen much adoption in legacy networks. We believe one of the primary reasons for this is the semantic gap between policy intents and policy configurations. The problem is further exacerbated by the heterogeneity, scale-on-the-fly, fragmentation, and lack of structure in non-intent native networks. We introduce Policy Intent Inference (PII) System to bridge the semantic gap with its advanced inference layer that extracts the policy intents from policy configurations fragmented over disparate network devices. We adopt a bottom-up approach to extract all policies within network devices, abstract them into a structured data model, and with the use of clustering and information retrieval techniques, build an optimal solution to extract network-wide policy intents from the underlying network that eases policy management especially policy troubleshooting, reducing the configuration clutter and reducing the time taken to compile and resolve conflicts in policies.
The respiratory burst-inhibiting acid phosphatase AcpA is not essential for the intramacrophage growth or virulence ofFrancisella novicida (1999)

Acid phosphatases capable of inhibiting the respiratory burst of neutrophils have been identified in certain intracellular pathogens. Here we evaluate the role of AcpA, a respiratory burst-inhibiting acid phosphatase of Francisella, in the virulence and intracellular growth of this organism. An F. novicida acpA null mutant was created and found to exhibit wild-type growth kinetics in both cell-line and inflammatory mouse macrophages. The acpA mutant also shows wild-type replication in the spleens of experimentally infected mice. These data suggest that AcpA is not essential for the intracellular growth or virulence of F. novicida.
Transparent Barrier Coatings Update: Flexible Substrates (1993)

SiO x thin films continue to be developed for polymeric flexible substrates. During the past year significant progress has been made on plasma deposition onto PET, LDPE, BOPP and BON polymer films. In addition, the first two 1.5 meter wide plasma roll coaters were completed and installed. The current state of the roll-to-roll coating developments on BOPP, LDPE, PET and BON will be reported for the 0.3 meter wide roll coater, R9, the 0.66 meter wide roll coater, Flex-1, along with data from the 1.5 meter wide coater, Flex-3, oper ations. The article focuses on a new stretch tester that measures oxygen trans mission of stretched SiO x coated polymers. Data from the plasma coatings along with comparative measurements made on commercially available evapo rated products clearly shows a strong inverse relationship between the SiO x coating thickness and the onset of failure (strain) S f . Plasma coatings were stretched to 11.9% before failure occurred while the evaporated materials degraded at S f = 2-3%. The stretch tester is a repeatable technique to assess the convertibility of the SiO x coated polymers and to make quantitative assess ments between competitive materials. A model is also presented outlining the key parameters in achieving gas barrier properties with thin SiO x and AlO x coatings.
A pilot study of group exercise training (GET) for women with primary breast cancer: feasibility and health benefits (2002)

Evidence is accumulating for physical activity as an effective, well-tolerated, highly rewarding complementary behavioral intervention for enhancing quality of life (QOL) as well as fitness among individuals with chronic and even terminal illnesses. However, relatively few studies have examined the feasibility and potential health benefits of supervised, structured exercise programs for sedentary women with primary breast cancer. Forty women over the age of 45 with primary breast cancer participated in a course of group exercise training (GET) delivered in a structured format three times per week for 16 weeks. GET emphasizes physical activities that promote aerobic fitness, strength, and flexibility. Assessments of fitness/vigor and QOL were conducted prior to, during, and upon completion of the program. Results demonstrated that GET was feasible, safe, and well-tolerated. Moreover, the participants experienced significant health benefits over the course of the intervention in multiple dimensions of fitness/vigor (aerobic capacity, strength, flexibility) as well as QOL (increased positive affect, decreased distress, enhanced well-being, and improved functioning). Discussion highlights the need for inclusion of physical activity programs in comprehensive, complementary treatment regimes for breast cancer patients.
3-[3,5-Dimethoxy-2-(trimethylsilyl)phenyl]-4-trimethylsilylsydnone (2007)

The title compound, C16H26N2O4Si2, is a mesoionic compound of the sydnone class. Its mol­ecular structure reveals the two planar ring fragments mutually twisted by 74.88 (10)°. The crystal packing is characterized by a one-dimensional mol­ecular array generated by C—H⋯O inter­actions.
Transistor-level estimation of worst-case delays in MOS VLSI circuits (1992)

The authors present three algorithms for efficient worst-case delay estimation in transistor groups using transistor-level delay models and timing simulation techniques. The first algorithm, dynamic path selection (DPS), determines the path with the longest delay in a transistor group. If the group consists of series-parallel transistor combinations, the time complexity is linear. The second algorithm, delay subnetwork enumeration (DSE), complements the DPS method by taking into account logic dependencies. The paths with the shortest delay are computed using the dynamic cut selection (DCS) algorithm. These techniques have been implemented in the static timing analyzer TAMIA to provide fast and accurate worst-case delay estimation for digital CMOS circuits.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Geometrical magnetothermopower inn- andp-type InSb (2001)

In a previous paper [Heremans et al., Phys. Rev. Lett. 86, 2098 (2001)] we reported how the geometry of a sample of lightly p-type InSb can be manipulated to create a very large change of the thermoelectric power with magnetic field. That effect was called the geometrical magnetothermopower (GMT). In this paper, we review and extend the results in p-type InSb, and present a study of the GMT in n-type InSb. We conclude that, in semiconductors with two types of carriers of different mobilities, the GMT effect makes the thermopower change from being dominated by a high-mobility carrier at zero magnetic field to being dominated by a low-mobility carrier at high field, even when the low-mobility carrier is the minority carrier. We complete the study of the reciprocity relations in macroscopic two-contact thermoelectric systems by adding to the experimental verification of the Kelvin relation the new observation that the GMT is an even function of magnetic field, even in asymmetric geometries. Finally, we model the GMT in both n- and p-type InSb using classical transport theory, and show how this model predicts that the GMT effect can lead to an increase of the thermoelectric power factor, and of the figure of merit, by over 80%.
Faculty Opinions recommendation of Is blood transfusion associated with an increased risk of infection among spine surgery patients?: A meta-analysis. (2019)

BACKGROUND: Blood transfusions are associated with many adverse outcomes among spine surgery patients, but it remains unclear whether perioperative blood transfusion during spine surgery and postoperative infection are related. Recently, many related cohort studies have been published on this topic.METHODS: This study was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The PubMed, Embase, and Cochrane Library databases were searched for eligible published studies. The Newcastle-Ottawa Scale (NOS) was used to assess the methodological quality of the studies, and a random-effects model was used to calculate the odds ratios (ORs) with 95% CIs. Sensitivity analyses were conducted to explore the source of heterogeneity.RESULTS: The final analysis included 8 cohort studies with a total of 34,185 spine surgery patients. These studies were considered to be of high or moderate quality based on their NOS scores, which ranged from 5 to 9. Pooled estimates indicated that blood transfusion increased the infection rate (OR, 2.99; 95% CI, 1.95 to 4.59; I = 86%), which was consistent with the sensitivity analyses.CONCLUSIONS: Our results suggest that perioperative blood transfusion is a risk factor for postoperative infection among spine surgery patients. Further study is necessary to identify other influencing factors and to establish the mechanism underlying this relationship. Additional measures may be needed to reduce unnecessary blood transfusions during spine surgery. PMID: 31305412
Scintigraphic diagnosis of protein-losing enteropathy secondary to amyloidosis. (2005)

Protein-losing enteropathy is an uncommon syndrome of excessive loss of protein via the gastrointestinal mucosa. 99mTc-dextran scintigraphy was performed on a 42-year-old woman with protein-losing enteropathy. She had secondary amyloidosis due to rheumatoid arthritis. Abnormal leakage of the radiotracer was observed in the mid-abdominal region suggesting the site of protein loss. It is concluded that 99mTc-dextran scintigraphy is useful as a noninvasive and simple test for the imaging and confirmation of diagnosis in protein-losing enteropathy.
Synthesis, Characterization, and Properties of Tethered Polystyrene-b-polyacrylate Brushes on Flat Silicate Substrates (2000)

Surface-immobilized polystyrene-b-polyacrylate brushes have been synthesized on silicate substrates from chlorine-terminated polystyrene (PS) brushes by atom transfer radical polymerization (ATRP). ATRP of methyl methacrylate (MMA), methyl acrylate (MA), and (N,N-dimethylamino)ethyl methacrylate (DMAEMA) produced tethered diblock copolymer brushes, which were characterized by ellipsometry, FTIR-ATR, tensiometry, and XPS. “Control” polymerizations supported a radical mechanism for the MMA polymerization. The thickness of the polyacrylate terminal block was controlled by free initiator concentration. All three diblock copolymer brushes underwent self-reorganization and exhibited different surface properties in response to different solvent treatments. For PS-b-PMMA and PS-b-PMA brushes, treatment with CH2Cl2 resulted in localization of PMMA and PMA at the air interface; treatment with cyclohexane localized the PS block at the air interface. PS-b-PDMAEMA brushes exhibited a similar behavior using cyclohexane and THF/H2O (v/v = 1:1).
Impact of coronary artery disease on outcomes of severe aortic stenosis treatment with transcatheter aortic valve implantation (2019)

The short- and mid-term outcomes of TAVI patients with CAD, despite higher risk profile, did not differ from the outcomes of treatment in patients without CAD.
Detection of text marks on moving vehicles (2004)

Vehicle text marks are unique features which are useful for identifying vehicles in video surveillance applications. We propose a method for finding such text marks. An existing text detection algorithm is modified such that detection is increased and made more robust to outdoor conditions. False alarm is reduced by introducing a binary image test which remove detections that are not likely to be caused by text. The method is tested on a captured video of a typical street scene.
A MyD88-Deficient Mouse Model Reveals a Role for Nramp1 in Campylobacter jejuni Infection (2006)

Campylobacter jejuni is a major worldwide cause of enteric illnesses. Adult immunocompetent mice are not susceptible to C. jejuni infection. However, we show here that mice deficient in the adaptor protein myeloid differentiation factor 88 (MyD88), which is required for signaling through most Toll-like receptors, can be stably colonized by C. jejuni but not by isogenic derivatives carrying mutations in known virulence genes. We also found that Nramp1 deficiency increases the mouse susceptibility to C. jejuni infection when administered systemically. These results indicate that MyD88-deficient mice could be a useful model to study C. jejuni colonization and reveal a potential role for Nramp1 in the control of this bacterial pathogen.
Effect of sitagliptin on glucose control in adult patients with Type 1 diabetes: a pilot, double-blind, randomized, crossover trial (2011)

Sitagliptin significantly improved overall glucose control, including postprandial and 24-h glucose control, in adult patients with Type 1 diabetes, while significantly reducing prandial insulin requirements. Further investigation is warranted in patients with Type 1 diabetes in a larger cohort designed to assess both clinical outcomes and mechanism of action.