gebhart/patrepeval huggingface dataset:
Parkinson's Disease Spatial Covariance Pattern: Noninvasive Quantification with Perfusion MRI (2010)

Parkinson's disease (PD) is associated with elevated expression of a specific disease-related spatial covariance pattern (PDRP) in radiotracer scans of cerebral blood flow and metabolism. In this study, we scanned nine early-stage patients with PD and nine healthy controls using continuous arterial spin labeling (CASL) perfusion magnetic resonance imaging (pMRI). Parkinson's disease-related metabolic pattern expression in CASL pMRI scans was compared with the corresponding (18)F-fluorodeoxyglucose positron emission tomography values. The PDRP expression was abnormally elevated (P<0.01) in patients scanned with either modality, and the two values were highly intercorrelated (P<0.0001). Perfusion MRI methods can be used for accurate quantification of disease-related covariance patterns.
ChemInform Abstract: GAS‐PHASE REACTIONS OF TRANSITION‐METAL IONS WITH METHYL NITRITE AND NITROMETHANE (1985)

Abstract Die Reaktionen von Fe , Co , Ni" Cu , Rh , Pd+ und Ag+ mit Methylnitrit verlaufen unter oxidativer Einlagerung des Metallions in die schwache MeO‐ NO‐Bindung zu Intermediärprodukten, die bedingt durch die Reaktivitätsunterschiede der Metalle zu verschiedenen Sekundärprodukten führen, deren Struktur durch kollisionsinduzierte Dissoziation und H/D‐Austausch‐Reaktionen untersucht wurde.
Intraosseous Delivery of Lentiviral Vectors Targeting Factor VIII Expression in Platelets Corrects Murine Hemophilia A (2015)

Intraosseous (IO) infusion of lentiviral vectors (LVs) for in situ gene transfer into bone marrow may avoid specific challenges posed by ex vivo gene delivery, including, in particular, the requirement of preconditioning. We utilized IO delivery of LVs encoding a GFP or factor VIII (FVIII) transgene directed by ubiquitous promoters (a MND or EF-1α-short element; M-GFP-LV, E-F8-LV) or a platelet-specific, glycoprotein-1bα promoter (G-GFP-LV, G-F8-LV). A single IO infusion of M-GFP-LV or G-GFP-LV achieved long-term and efficient GFP expression in Lineage(-)Sca1(+)c-Kit(+) hematopoietic stem cells and platelets, respectively. While E-F8-LV produced initially high-level FVIII expression, robust anti-FVIII immune responses eliminated functional FVIII in circulation. In contrast, IO delivery of G-F8-LV achieved long-term platelet-specific expression of FVIII, resulting in partial correction of hemophilia A. Furthermore, similar clinical benefit with G-F8-LV was achieved in animals with pre-existing anti-FVIII inhibitors. These findings further support platelets as an ideal FVIII delivery vehicle, as FVIII, stored in α-granules, is protected from neutralizing antibodies and, during bleeding, activated platelets locally excrete FVIII to promote clot formation. Overall, a single IO infusion of G-F8-LV was sufficient to correct hemophilia phenotype for long term, indicating that this approach may provide an effective means to permanently treat FVIII deficiency.
Driveline Features as Risk Factor for Infection in Left Ventricular Assist Devices: Meta-Analysis and Experimental Tests (2021)

<b>Background:</b> Risk factors for driveline infection (DLI) in patients with left ventricular assist devices are multifactorial. The aim of this study was to analyze the correlation between mechanical driveline features and DLI occurrence. <b>Methods:</b> A meta-analysis was conducted that included studies reporting DLI rates at 6 months after implantation of any of three contemporary devices (HVAD with Pellethane or Carbothane driveline, HeartMate II, and HeartMate 3). Further, outer driveline diameter measurements and <i>ex-vivo</i> experimental three-point bending and torsion tests were performed to compare the stiffness of the four different driveline types. <b>Results:</b> 21 studies with 5,393 patients were included in the meta-analysis. The mean weighted DLI rates ranged from 7.2% (HeartMate II) to 11.9% (HeartMate 3). The HeartMate II driveline had a significantly lower maximal bending force (Load<sub>max</sub>) (4.52 ± 0.19 N) compared to the Carbothane HVAD (8.50 ± 0.08 N), the HeartMate 3 (11.08 ± 0.3 N), and the Pellethane HVAD driveline (15.55 ± 0.14 N) (<i>p</i> < 0.001). The maximal torque (Torque<sub>max</sub>) of the HeartMate II [41.44 (12.61) mNm] and the Carbothane HVAD driveline [46.06 (3.78) mNm] were significantly lower than Torque<sub>max</sub> of the Pellethane HVAD [46.06 (3.78) mNm] and the HeartMate 3 [95.63 (26.60) mNm] driveline (<i>p</i> < 0.001). The driveline of the HeartMate 3 had the largest outer diameter [6.60 (0.58) mm]. A relationship between the mean weighted DLI rate and mechanical driveline features (Torque<sub>max</sub>) was found, as the the HeartMate II driveline had the lowest Torque<sub>max</sub> and lowest DLI rate, whereas the HeartMate 3 driveline had the highest Torque<sub>max</sub> and highest DLI rate. <b>Conclusions:</b> Device-specific mechanical driveline features are an additional modifiable risk factor for DLI and may influence clinical outcomes of LVAD patients.
Synthesis of New Pyrazoline Derivatives and Its Antimicrobial and Antioxidant Activities (2017)

Resistance gained by microorganism to conventional
antimicrobial agents has lead to the development of new
antimicrobial agents against pathogenic microbes. Chalcones
and their derivatives proved to be an important molecular
scaffold for the search of new pharmaceutically active molecules. Among the various derivatives of chalcones, synthesis of pyrazolines has gained major attention due to their promising biological activities such as anticancer, antimicrobial, antidepressant, immunosuppressive, anti-inflammatory, etc.1−8 Many studies revealed that incorporation of pyrazole moiety into various heterocyclic ring systems gives worthwhile molecules from the biological point of view.9−11 Several marketed drugs such ascelecoxib12 and rimonabant13 contains pyrazole as their core molecular unit.14,15
Finite Radial Reconstruction for Magnetic Resonance Imaging: A Theoretical Study (2016)

Magnetic resonance (MR) imaging is an important imaging modality for diagnostic medicine due to its ability to visualize the soft tissue of the human body in three dimensions (3D) without ionizing radiation. MR imaging however, typically relies on measurement techniques that do not exploit the geometry of discrete Fourier space, so called k-space, where the measurements are made. In this work, we firstly present a novel k-space tiling scheme that utilizes the finite geometry of discrete Fourier space via the discrete Fourier slice theorem. This produces a sampling of k-space that is pseudo-radial, to be more noise and patient-movement tolerant, and pseudo-random, further improving robustness to noise, whilst sampling with sufficient density near the central k-space region, where the majority of power of anatomical images lies. Secondly, we introduce a stable and iterative discrete reconstruction scheme for recovering images from their limited k-space measurements (in the form discrete slices) based on the maximum likelihood expectation maximization approach. We study the performance of the proposed approach using simulated MR measurements in k-space.
The Image chip for high performance 3D rendering (1992)

The Image chip, which accelerates 3D rendering algorithms base on Bresenham's line drawing and Pineda's parallel polygon drawing algorithms, is discussed. With these algorithms, Image can directly draw lines, spans, and triangles in wireframe, hidden-line, and Gouraud-shading modes. Image also directly antialiases vectors or provides antialiasing information to enhance antialiasing of vectors or triangles. Image's operation, separation into layers to maximize performance and simplify the input and output interfaces, and support of advanced rendering effects such as Phong shading and texture mapping are described. The designs of Image's internal architecture, host interface, and memory interface are also described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
[Compressed sensing magnetic resonance image reconstruction based on double sparse model]. (2018)

The medical magnetic resonance (MR) image reconstruction is one of the key technologies in the field of magnetic resonance imaging (MRI). The compressed sensing (CS) theory indicates that the image can be reconstructed accurately from highly undersampled measurements by using the sparsity of the MR image. However, how to improve the image reconstruction quality by employing more sparse priors of the image becomes a crucial issue for MRI. In this paper, an adaptive image reconstruction model fusing the double dictionary learning is proposed by exploiting sparse priors of the MR image in the image domain and transform domain. The double sparse model which combines synthesis sparse model with sparse transform model is applied to the CS MR image reconstruction according to the complementarity of synthesis sparse and sparse transform model. Making full use of the two sparse priors of the image under the synthesis dictionary and transform dictionary learning, the proposed model is tackled in stages by the iterative alternating minimization algorithm. The solution procedure needs to utilize the synthesis and transform K-singular value decomposition (K-SVD) algorithms. Compared with the existing MRI models, the experimental results show that the proposed model can more efficiently improve the quality of the image reconstruction, and has faster convergence speed and better robustness to noise.
Up-Gridding from Geological Model to Simulation Model: Review, Applications and Limitations (2004)

Abstract In recent years, several papers have presented methods for choosing an optimal coarse grid suitable for dynamic simulation, given a multi-million cell geological model as starting point. Usually these methods include some technique for measuring how well the coarse simulation grid represents the response of the original fine scale grid. In this paper, we describe a software package we have produced based on these methods. We discuss some of the difficulties encountered in applying the published methods to realistic reservoir models. We present our experience in using the methods in real case studies, both successfully and otherwise. Finally, we discuss the limitations of this type of approach to up-gridding.
Stability in Escherichia coli of an antibiotic resistance plasmid from Bacteroides fragilis (1981)

A Bacteroides fragilis strain resistant to penicillin G, tetracycline, and clindamycin was screened for the presence of plasmid deoxyribonucleic acid (DNA). Agarose gel electrophoresis of ethanol-precipitated DNA from cleared lysates of this strain revealed two plasmid DNA bands. The molecular weights of the plasmids were estimated by their relative mobility in agarose gel and compared with standard plasmids with known molecular weights. The molecular weights were 3.40 +/- 0.20 x 10(6) and 1.95 +/- 0.05 x 10(6) for plasmids pBY1 and pBY2, respectively. Plasmid DNA purified by cesium chloride-ethidium bromide gradient centrifugation was used to transform a restriction- and modification-negative strain of Escherichia coli. Penicillin G- and tetracycline-resistant transformants were screened for the presence of plasmid DNA. A plasmid band corresponding to a molecular weight of 1.95 x 10(6) was present in all transformants tested. Curing experiments demonstrated that the plasmid, referred to as pBY22 when present in transformants, was responsible for penicillin G and tetracycline resistance. Plasmid pBY22 was mobilized and transferred to other E. coli strains by plasmid R1drd-19. Stability of pBY22 was examined in different E. coli strains and was shown to be stably maintained in both restriction-negative and restriction-positive strains. Unexpectedly, pBY2 and pBY22 were resistant to digestion by 12 different restriction endonucleases.
Electromagnetic form factors of nucleon resonances from CLAS (2019)

Exclusive single and double meson photo- and electroproduction reactions are the largest sources of information on the spectrum and structure of nucleon resonances. The excited states of the nucleon manifest as a complex interplay between the inner core of three dressed quarks and the external meson-baryon cloud. Various N* with distinctively different structure appear as unique laboratory where many features of strong QCD can be explored. With combination of nearly 4π acceptance of the CLAS detector and continuous electron beam (Jefferson Lab, USA) it is possible to obtain physics observables of the major reaction channels in the N* excitation region. The results on the electromagnetic transition form factors of N(1440)1/2 + and N(1520)3/2 - are presented.
Interpolated array minimum variance beamforming for correlated interference rejection (2002)

Signal cancellation causes the performance of conventional adaptive beamformers to severely deteriorate in environments containing interference sources that are correlated with the signal. We propose an algorithm which overcomes the signal cancellation problem for wideband signals. The proposed algorithm applies array manifold interpolation to perform frequency domain averaging, which reduces the correlation between the signals and the interference sources. In contrast to other algorithms that apply frequency averaging, the algorithm proposed does not require any preliminary estimation or prior information on the interference environment.
Answering XML queries by means of data summaries (2007)

XML is a rather verbose representation of semistructured data, which may require huge amounts of storage space. We propose a summarized representation of XML data, based on the concept of instance pattern, which can both provide succinct information and be directly queried. The physical representation of instance patterns exploits itemsets or association rules to summarize the content of XML datasets. Instance patterns may be used for (possibly partially) answering queries, either when fast and approximate answers are required, or when the actual dataset is not available, for example, it is currently unreachable. Experiments on large XML documents show that instance patterns allow a significant reduction in storage space, while preserving almost entirely the completeness of the query result. Furthermore, they provide fast query answers and show good scalability on the size of the dataset, thus overcoming the document size limitation of most current XQuery engines.
Automated High-Throughput Genotyping for Study of Global Epidemiology of Mycobacterium tuberculosis Based on Mycobacterial Interspersed Repetitive Units (2001)

Large-scale genotyping of Mycobacterium tuberculosis is especially challenging, as the current typing methods are labor-intensive and the results are difficult to compare among laboratories. Here, automated typing based on variable-number tandem repeats (VNTRs) of genetic elements named mycobacterial interspersed repetitive units (MIRUs) in 12 mammalian minisatellite-like loci of M. tuberculosis is presented. This system combines analysis of multiplex PCRs on a fluorescence-based DNA analyzer with computerized automation of the genotyping. Analysis of a blinded reference set of 90 strains from 38 countries (K. Kremer et al., J. Clin. Microbiol. 37:2607-2618, 1999) demonstrated that it is 100% reproducible, sensitive, and specific for M. tuberculosis complex isolates, a performance that has not been achieved by any other typing method tested in the same conditions. MIRU-VNTRs can be used for analysis of the global genetic diversity of M. tuberculosis complex strains at different levels of evolutionary divergence. To fully exploit the portability of this typing system, a website was set up for the analysis of M. tuberculosis MIRU-VNTR genotypes via the Internet. This opens the way for global epidemiological surveillance of tuberculosis and should lead to novel insights into the evolutionary and population genetics of this major pathogen.
Supplementary Table 2 from Altered TGF-β Signaling in a Subpopulation of Human Stromal Cells Promotes Prostatic Carcinogenesis (2023)

Supplementary Table 2 from Altered TGF-β Signaling in a Subpopulation of Human Stromal Cells Promotes Prostatic Carcinogenesis
Impact of the environment on Egyptian civilization before the pharaohs (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImpact of the environment on Egyptian civilization before the pharaohsRalph O. Allen, Hany Hamroush, and Daniel J. StanleyCite this: Anal. Chem. 1993, 65, 1, 32A–43APublication Date (Print):January 1, 1993Publication History Published online22 September 2008Published inissue 1 January 1993https://doi.org/10.1021/ac00049a002RIGHTS & PERMISSIONSArticle Views227Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (9 MB) Get e-Alerts Get e-Alerts
The Role of Extralinguistic Factor in the Formation of German Toponymicon (On the Way of Example of Ideological Component in Northern and Eastern Germany from 1933 to the 1990s) (2011)

The article, which focuses on place names of Northern and Eastern Germany, conclusively shows that renaming is one of the most obvious symbols of social change and that toponymy plays an important political role under certain circumstances. The new paradigm of anthropocentric linguistics opens the way for interdisciplinary research and enables to make the most out of extra-linguistic factor in the analysis of extra-linguistic studies. The author examines the types of renaming, their specific features, which are characteristic of different periods. The general trends of oikonyms’ renaming are also examined in detail. The author shows that place-names are cultural heritage; they serve as reference points in space and time. During its existence, they accumulate unique information about the history, culture and language of people.
A new experimental trial protocol for laboratory investigations of bitumen fumes : Influence of stirring and steamed water on emissions (2008)

Development of pavement bituminous materials using steamed water to foam bitumen has been recently observed. Besides, it is well known that stirred warm bitumen generates organic emissions. Although some methods already exist to generate and characterize bitumen fumes, no specific study has been published involving bitumen in the presence of steamed water. In order to fill this gap, LCPC has developped a test bench allowing to collect and to analyse the emissions of emitted Total Organic Compounds 'TOC(e)' from bitumen in temperature and stirring controlled conditions. The influence of bitumen stirring and steamed water addition on organic fumes were studied thanks to the development of an experimental trial protocol. This study highlights the influence of the stirring process on TOC emissions as well as their progressive exhaustion during long-term tests. The additions of steamed water to the bitumen leads to an increase of emitted Total Organic Compounds. These results can be interpreted as a stripping water chemical mechanisms.
Electron spin resonance studies of radicals and radical-ions in solution. Part IV. Further intermediates in the reduction of aromatic nitro- and nitroso-compounds (1966)

The oxidation and reduction of nitrosobenzene, phenylhydroxylamine, and some of their derivatives have been studied by electron spin resonance methods in a variety of solvents. From the observed spectra the species PhNO– and PhṄHO have been identified. PhNO– is observed only in strongly alkaline solution and in the immediate vicinity of the cathode during the electrolytic reduction of nitrosobenzene. In neutral or acid solution PhNO–is replaced by PhNHO which is identical with the first oxidation product of phenylhydroxylamine. The role of these paramagnetic species in the reduction of aromatic nitro-compounds is discussed briefly.
Bestimmung der Lebenszeit der nach akuter Blutung gebildeten Rattenerythrozyten (C14‐Hämin) (1962)

Abstract F orssberg , A. und B. T ribukait . Bestimmung der Lebenszeit der nach akuter Blutung gebildeten Rattenerythrozyten (C 14 ‐Hamin). Acta physiol. scand. 1962. 54. 152–158. – The average life time of rat erythrocytes following an acute bleeding was found to be about 55 days, similar to that of normal animals. The rats were bled 1/3 of their blood volume by heart puncture. On the third day they were given 10 μC C 14 ‐2‐glycine each intraperitoneally. The hemin was isolated from volumes of 0.1–0.2 ml blood drawn from the tail vein and the specific activity was computed. Simultaneously the total amount of hemin was determined following the CO method, giving the total haemin activity. The hemin of the control animals was found to retain 0.2–0.3 % of the injected activity against 0.4–0.5 % in the anemic ones. The hemin activity in both groups of animals remained on a plateau level for 40 days, and fell thereafter exponentially up to the 85th day.
In Vivo Imaging of Bone Regeneration Induced by Angiogenic and Osteoinductive Hydrogel Scaffolds (2006)

Hydrogel scaffolds releasing angiogenic and osteoinductive molecules were used to induce bone growth in a bone defect model. Optical coherence tomography was utilized to characterize morphological changes during the temporal progression of bone regeneration.
Development of High Voltage Pulse Power Supply for Microwave Tube Applications (2017)

This paper describes about the design and development of high voltage DC pulse power supply for high power applications. The system has variety of features such as independent control of Pulse Repetition Frequency (PRF), Pulse Duration (Ton) and pulse amplitude. PC based wireless pulse generation and control unit with Graphical User Interface (GUI) having variable/controlled PRF (10Hz-1 kHz) and T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> (10-100μ s) is developed for gating pulse generation. Two sets of -25kV, 10A pulse power supplies are connected in series to achieve -50kV, 10A pulse output voltage. High voltage DC pulse power supply is used for the characterization of high power microwave tube and testing applications. To verify the proposed design, simulation and experimental results on resistive load are presented in this paper.
Applications of surface textures produced with natural lithography (1983)

Surface textures with carefully controlled size, order, and morphology can be prepared by using monolayers of colloidal particles to form a lithographic mask. Microstructures produced from the mask are identical and of predetermined size because monodisperse colloidal particles can be obtained in sizes ranging from ∼200 Å–30 μm. Ordering of particles, and hence, surface texture can be either random or periodic depending upon the method used to deposit the particles. Several applications of reproducible fine structure fabricated on the surface of large area substrates are discussed.