gebhart/patrepeval huggingface dataset:
EDOT‐diketopyrrolopyrrole copolymers for high bulk hole mobility and near infrared absorption (2015)

ABSTRACT To obtain novel low‐bandgap materials with tailored hole‐transport properties and extended absorption, electron rich 3,4‐ethylenedioxythiophene is introduced as a comonomer in diketopyrrolo[3,4‐ c ]pyrrole copolymers with different aryl flanking units. The polymers are characterized by absorption and photoluminescence spectroscopy, dynamic scanning calorimetry, cyclic voltammetry, and X‐ray diffraction. The charge transport properties of these new materials are studied carefully using an organic field effect transistor geometry where the charge carriers are transported over a narrow channel at the semiconductor/dielectric interface. These results are compared to bulk charge carrier mobilities using space‐charge limited current (SCLC) measurements, in which the charge carrier is transported through the complete film thickness of several hundred nanometers. Finally, charge carrier mobilities are correlated with the electronic structure of the compounds. We find that in particular the thiophene‐flanked copolymer PDPP[T] 2 ‐EDOT is a very promising candidate for organic photovoltaics, showing an absorption response in the near infrared region with an optical bandgap of 1.15 eV and a very high bulk hole mobility of 2.9 × 10 −4 cm 2 V −1 s −1 as measured by SCLC. This value is two orders of magnitudes higher than SCLC mobilities reported for other polydiketopyrrolopyrroles and is in the range of the well‐known hole transporting polymer poly(3‐hexylthiophene). © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016 , 54 , 639–648
Implementing a Collaboratory for Microscopic Digital Anatomy (1996)

The Collaboratory for Microscopic Digital Anatomy (CMDA) will allow biologists at remote locations to acquire over the network three-dimensional data on biological structure using a sophisticated high-voltage electron mi croscope (HVEM) located in San Diego. The CMDA will transparently distribute to high-performance machines on the network computationally intensive tasks for the deriva tion of three-dimensional datasets from HVEM images using tomography and for volume visualization. Implemen tation of the CMDA includes development of automated microscope functions for specimen positioning, image fo cus, registration, and acquisition; an asynchronous com munications system for transporting messages and large data sets between processes; a resource manager for access control and routing of tasks to computing or acqui sition resources; and systems for tomographic reconstruc tion and three-dimensional volume visualization. The CMDA is designed to be extensible to other unique cen tralized instruments. It will increase access to and use of these instruments and high-performance computers by biologists and facilitate remote collaboration.
Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210 (2015)

Autophagy in L. m.-infected host macrophages is a highly regulated cellular process at both the RNA level and the protein level. Autophagy has the potential to clear parasites from the host. The results obtained from experiments with murine host macrophages could be translated in the future to develop innovative and therapeutic antileishmanial strategies for human patients.
Intraoperative Monitoring with Stimulus-Evoked Electromyography during Placement of Iliosacral Screws. An Initial Clinical Study* (1998)

A consecutive series of twenty-seven patients who had thirty acute unstable (type-C) fractures of the pelvic ring was studied prospectively to evaluate the use of stimulus-evoked electromyography to decrease the risk of iatrogenic nerve-root injury during the insertion of iliosacral screws. A prerequisite for inclusion in the study was a normal neurological status preoperatively; somatosensory evoked potentials were monitored to further document the neurological status both before and after insertion of the screw or screws. A total of fifty-one iliosacral screws were inserted, and a current threshold of more than eight milliamperes was selected as the level that indicated that the drill-bit was a safe distance from the nerve root. Four of the fifty-one screws were redirected because of information obtained with stimulus-evoked electromyography. Postoperatively, all patients had a normal neurological status. Computerized tomography, although not accurate for detailed measurements, demonstrated that all of the screws were in a safe, intraosseous position. Monitoring with stimulus-evoked electromyography appears to provide reliable data and may decrease the risk of iatrogenic injury to the nerve roots during operations on the pelvic ring.
High Magnetic Permeability Alloys &ldquo;Hardperm&rdquo; in the Ni-Fe-Nb-W System (1976)

Ni-Fe-Nb-W alloys were heated in hydrogen atmosphere at 1150°C for 3 hr and then cooled at vairous rates from a temperature above order-disorder transformation points. The highest values of 109000 in initial permeability and 463000 in maximum permeability are obtained for the alloy of 79.45%Ni, 11.54%Fe, 8.51%Nb and 0.50%W when cooled at the rate of 240 and 300°C/hr, respectively. The electrical resistivity of the alloy cooled at 240°C/hr is 74.6 μΩ-cm, its Vickers Hardness being 202. These high permeability Ni-Fe-Nb-W alloys show very low saturation magnetostriction constants.
2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 5. 3',5'-Dimethoxy-4'-substituted-benzyl analogs of trimethoprim (1981)

Forty trimethoprim analogues in which the para substituent in the benzene ring was varied were prepared for antibacterial evaluation. All were very potent inhibitors of Escherichia coli dihydrofolate reductase. The similarity of their inhibitory activities strongly suggested that the side chains beyond the first two atoms were not in contact with the enzyme. However, among 38 ether derivatives which varied widely in their bulk and lipophilicity, very few approached trimethoprim in their broad-spectrum in vitro antibacterial activity. The 4'-methyl and 4'-ethyl analogues and the allyloxy and gamma-chloropropoxy ethers had activities fairly close to that of trimethoprim. The two ethers were chosen for further evaluation in vivo. Neither compound quite matched trimethoprim in efficacy in mice, and their half-lives, as well as that of the beta-methoxyethoxy analogue, were found to be shorter in dogs.
Design of extended end-plate connections for hollow section columns (1996)

Extended end-plate connections have been widely used in moment-resisting steel frames with W-shape columns, due to their sufficient stiffness and moment capacity. In addition, such connections are easy to install and permit good quality control. Extended end-plate connections can also be employed in moment-resisting frames with hollow structural section columns by using high strength blind bolts. These bolts have been developed for installation from one side only where the rear side of the connection is inaccessible. In this study, a quantitative procedure for detailing and designing beam extended end-plate connections for rectangular hollow structural section columns using high strength blind bolts is proposed. The design procedure is consistent with the design philosophy given in limit-state codes. The proposed design is based on the results obtained from an experimental program and an analytical study. Key words: design, end plate, connection, hollow section, blind bolts, steel, frame.
Bond strength of 3D-stacked monocrystalline silicon X-ray mirrors (2017)

This paper investigates the bond strength of flat directly-bonded structured monocrystalline silicon X-ray mirrors. We report on the sample manufacturing method and tensile strength testing measurements used to study the influence of annealing.
Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe (2018)

European populations display low genetic diversity as the result of long term blending of the small number of ancient founding ancestries. However it is still unclear how the combination of ancient ancestries related to early European foragers, Neolithic farmers and Bronze Age nomadic pastoralists can fully explain genetic variation across Europe. Populations in natural crossroads like the Italian peninsula are expected to recapitulate the overall continental diversity, but to date have been systematically understudied. Here we characterised the ancestry profiles of modern-day Italian populations using a genome-wide dataset representative of modern and ancient samples from across Italy, Europe and the rest of the world. Italian genomes captured several ancient signatures, including a non-steppe related substantial ancestry contribution ultimately from the Caucasus. Differences in ancestry composition as the result of migration and admixture generated in Italy the largest degree of population structure detected so far in the continent and shaped the amount of Neanderthal DNA present in modern-day populations.
Oral loading of propafenone: restoring its role before restoring rhythm (2017)

N/A
New Small Nuclear RNA Gene-Like Transcriptional Units as Sources of Regulatory Transcripts (2007)

By means of a computer search for upstream promoter elements (distal sequence element and proximal sequence element) typical of small nuclear RNA genes, we have identified in the human genome a number of previously unrecognized, putative transcription units whose predicted products are novel noncoding RNAs with homology to protein-coding genes. By elucidating the function of one of them, we provide evidence for the existence of a sense/antisense-based gene-regulation network where part of the polymerase III transcriptome could control its polymerase II counterpart.
An Implementation and Experimental Evaluation of Hardware Accelerated Ciphers in All-Programmable SoCs (2017)

The protection of confidential information has become very important with the increase of data sharing and storage on public domains. Data confidentiality is accomplished through the use of ciphers that encrypt and decrypt the data to impede unauthorized access. Emerging heterogeneous platforms provide an ideal environment to use hardware acceleration to improve application performance. In this paper, we explore the performance benefits of an AES hardware accelerator versus the software implementation for multiple cipher modes on the Zynq 7000 All-Programmable System-on-a-Chip (SoC). The accelerator is implemented on the FPGA fabric of the SoC and utilizes DMA for interfacing to the CPU. File encryption and decryption of varying file sizes are used as the workload, with execution time and throughput as the metrics for comparing the performance of the hardware and software implementations. The performance evaluations show that the accelerated AES operations achieve a speedup of 7 times relative to its software implementation and throughput upwards of 350 MB/s for the counter cipher mode, and modest improvements for other cipher modes.
Complementation Mapping of Skeletal and Central Nervous System Abnormalities in Mice of the piebald Deletion Complex (1996)

The s15DttMb, s36Pub, s1Acrg and s24Pub piebald deletion alleles belong to a set of overlapping deficiencies on the distal portion of chromosome 14. Molecular analysis was used to define the extent of the deletions. Mice homozygous for the smallest deletion, s15DttMb, die shortly after delivery and display alterations in the central nervous system, including hydrocephalus and a dorsally restricted malformation of the spinal cord. These mice also display homeotic transformations of vertebrae in the midthoracic and lumbar regions. Homozygous s27Pub mice contain a point mutation in the piebald gene, survive to weaning, and display no central nervous system or skeletal defects, arguing that the s15DttMb phenotype results from the loss of genes in addition to piebald. A larger deletion, s36Pub, exhibits additional cartilage malformations and defects in the anterior axial and cranial skeleton. The skeletal defects in both s15DttMb and s36Pub mice resemble transformations associated with the targeted disruption of Hox genes and genes encoding the retinoic acid receptors, which play a role in the specification of segmental identity along the anteroposterior axis. Complementation analysis of the s15DttMb and s36Pub phenotypes, using two additional deletions, localized the gene(s) associated with each phenotype to a defined chromosomal region.
Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly (2018)

Centrosomes are required for faithful chromosome segregation during mitosis. They are composed of a centriole pair that recruits and organizes the microtubule-nucleating pericentriolar material. Centriole duplication is tightly controlled in vivo and aberrations in this process are associated with several human diseases, including cancer and microcephaly. Although factors essential for centriole assembly, such as STIL and PLK4, have been identified, the underlying molecular mechanisms that drive this process are incompletely understood. Combining protein proximity mapping with high-resolution structural methods, we identify CEP85 as a centriole duplication factor that directly interacts with STIL through a highly conserved interaction interface involving a previously uncharacterised domain of STIL. Structure-guided mutational analyses in vivo demonstrate that this interaction is essential for efficient centriolar targeting of STIL, PLK4 activation and faithful daughter centriole assembly. Taken together, our results illuminate a molecular mechanism underpinning the spatiotemporal regulation of the early stages of centriole duplication.
KineAssist: Design and Development of a Robotic Overground Gait and Balance Therapy Device (2008)

Design and development of the KineAssist proceeded more rapidly in the context of a small company than would have been possible in most institutional research contexts. A prototype KineAssist has been constructed and has received US Food and Drug Administration (FDA) classification and institutional review board clearance for initial human studies. The acceptance of KineAssist will ultimately depend on improved patient outcomes, the use of this new tool by therapists, the ease of use of the system, and the recognition of the unique value it brings to therapeutic recovery.
Effect of Auger recombination on the threshold characteristics of semiconductor injection lasers (1982)

Auger recombination on the threshold characteristics of semiconductor injection lasers is studied. (AIP)
Reference Command Shaping Using Specified-Negative-Amplitude Input Shapers for Vibration Reduction (2004)

Residual vibrations can be greatly reduced by using specially-shaped reference command signals. Input shaping is one such technique that reduces vibration by convolving a sequence of impulses with any desired reference command. Several types of useful impulse sequences have been developed. Most of these have contained only positively valued impulses. However, rise time can be improved by using some negative impulses in the sequence. Unfortunately, the use of negative impulses can excite unmodeled high modes. A new type of impulse sequence containing negative impulses is proposed. These sequences are designed to fill the performance gap between all-positive impulse sequences and the negative sequences previously developed. A proof governing the worst case scenario provides an upper bound on high-mode excitation. The resulting class of impulse sequences allows the designer to make a precise trade off between rise time and vibration reduction.
P‐148: Temperature Dependence of Degradation in Organic Light‐Emitting Diodes (2009)

Abstract Prolonged operation of an OLED degrades the luminance and alters the voltage‐dependent capacitance. The loss of luminance in simple blue and green fluorescent OLEDs is linearly correlated with internal charge accumulation at the HTL|LEL interface. The shapes of the EL decay curve and the transition‐voltage‐rise curve are independent of temperature. Proper scaling of the time axis makes plots of EL or transition voltage vs. time at different temperatures to coincide. The resulting universal decay curves are not altered by the introduction of the fluorescent dopant, suggesting that the degradation processes are the same in the doped and undoped devices. Red fluorescent OLEDs of more complicated structure degrade in a dopant‐dependent manner.
OFFSHORE-PLATFORM DECOMMISSIONING PERCEPTIONS CHANGE (1997)

The oil and gas industry has seen a change in the perceptions about decommissioning offshore facilities. Now, decommissioning projects are being planned ahead of actual field development, and new concepts derived during decommissioning often are used to provide feedback for new development projects. The current trends and concepts applicable to decommissioning can be summarized as: advanced planning; engineered solutions; research and development; reuse; expanded use of offshore reefs; and deepwater disposal. Planning the platform decommissioning ahead of time (at least 2 years before production ceases) is key to a safe, environmentally conscious, and efficient decommissioning project. The paper discusses decommissioning projects, engineered solutions, research and development; reuse of platforms, and deepwater disposal.
ChemInform Abstract: Total Synthesis of the Proposed Structure of (+)‐Tolyporphin A O,O‐Diacetate. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Use of Inorganic Compounds in Photodynamic Therapy: Improvements in Methods and Photosensitizer Design (2017)

PDT is a suitable treatment option for several diseases however there are several challenges and limitations. The incorporation of NPs in the field of PDT is an extremely promising avenue which can be utilized to improve the execution of PDT. Furthermore, the use of inorganic compounds was noted to be frequented in the development of PSs and NP conjugates. The patents presented addressed the associated problems with PDT but there still remains an opportunity for continued research efforts so that more clinical applications are possible.
Supplementary Methods, Figure 1, Table 1 from Myocardin Functions as an Effective Inducer of Growth Arrest and Differentiation in Human Uterine Leiomyosarcoma Cells (2023)

Supplementary Methods, Figure 1, Table 1 from Myocardin Functions as an Effective Inducer of Growth Arrest and Differentiation in Human Uterine Leiomyosarcoma Cells
Experiment study on the rubber and fly ash of modified asphalt (2011)

This paper mainly used rubber and fly ash to modify matrix asphalt, expecting to get the reasonable rubber dosage and fly ash. The production technology of rubber asphalt, including cutting temperature, cutting time, production process, was determined by the laboratory experiment at different craft conditions according to rubber asphalt performance; The effects of different rubber particle size, dosage and fly ash dosage for modified asphalt penetration, low-temperature ductility, softening point and elastic restitution were analyzed to determine rubber particle size, optimal rubber dosage and fly ash dosage. They will affect the modified asphalt performance.
Stockholms etniska delning. Polarisering på arbets- och bostadsmarknaden. (2008)

Den kalla och varma staden staller huvudstadens utveckling under de senaste decennierna i centrum. Bokens artiklar behandlar ur ett brett samhallsvetenskapligt perspektiv hur staden har bidragit ...
Daunorubicin can eliminate iPS-derived cancer stem cells via ICAD/CAD-independent DNA fragmentation (2019)

<b>Aim:</b> To identify a drug that can effectively eliminate these cancer stem cells (CSCs) and determine its mode of action. <b>Methods:</b> CSCs were obtained from mouse induced pluripotent stem cells (miPSCs) using cancer cell-conditioned media. Drug screening was performed on these cells or after transplantation into mice. Apoptosis was analyzed by flow cytometry and western blotting. <b>Results:</b> Drug screening studies showed that daunorubicin, a topoisomerase II inhibitor, is specifically cytotoxic to miPS-CSCs. Daunorubicin-induced apoptosis was found to be associated with p53 accumulation, activation of the caspase cascade, and oligonucleosomal DNA fragmentation. Treatment with the caspase inhibitor abolished daunorubicin-induced DNA fragmentation and was therefore considered to act downstream of caspase activation. This was also suppressed by treatment with a Ca<sup>2+</sup>-specific chelator, which suggested that CAD endonuclease does not contribute. Moreover, no obvious ICAD reduction/degradation was detected. <b>Conclusion:</b> Daunorubicin effectively eliminated CSCs, which are dependent on the p53/caspase signaling cascade. The current findings provided the basis for further studies on CSC-targeted drugs for the development of cancer treatment strategies.
Abstract IA17: From functional genomics to new targets in pediatric oncology (2020)

Abstract The sequencing of human genomes harkened a new era of pediatric cancer investigations. Indeed, genomic discoveries, such as the identification of ALK mutations in neuroblastoma, Philadelphia-like fusions in acute B-cell acute lymphoblastic leukemia (B-ALL), and NTRK fusions in infantile fibrosarcoma, have led to early successes in the application of genomically informed, targeted therapy for children with cancer. While these new drugs have become an important part of the pediatric cancer armamentarium, many children with cancer still lack targeted therapies. Thus, new therapeutic approaches are still needed. Approaches such as RNA interference and CRISPR-Cas9 have transformed the functionalizing of the genome and offer promise for identifying new cancer therapeutic targets. We have applied genome-scale CRISPR-CAS9 screening to identify novel therapeutic targets in pediatric malignancies through the development of a Pediatric Cancer Dependency Map. We screened the Broad Institute’s Avana library in over 100 pediatric cancer cell lines and compared their dependencies to over 600 nonpediatric cell lines. Novel targets emerging from these efforts will be discussed. Citation Format: Kimberly Stegmaier. From functional genomics to new targets in pediatric oncology [abstract]. In: Proceedings of the AACR Special Conference on the Advances in Pediatric Cancer Research; 2019 Sep 17-20; Montreal, QC, Canada. Philadelphia (PA): AACR; Cancer Res 2020;80(14 Suppl):Abstract nr IA17.
S-Adenosyl-L-Methionine protects the probiotic yeast, Saccharomyces boulardii,from acid-induced cell death (2013)

In toto, given the observation that many of the proven health benefits of S. boulardii are dependent on cell viability, our data suggests that taking S. boulardii and AdoMet together may be a more effective treatment for gastrointestinal disorders than taking the probiotic yeast alone.
Distinguishing between similar tubular objects using pulse reflectometry: a study of trumpet and cornet leadpipes (2002)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
Clinical and Morphological Conditions in Capsular Contracture Formed around Silicone Breast Implants (2007)

The authors demonstrated a positive correlation (p < 0.05) between the clinical classification (Baker score I to IV) and the histological classification introduced by Wilflingseder (Wilflingseder score I to IV). An exact histological classification is needed to describe precisely the morphological changes in capsular contracture.
Fabrication of (MoSi2-SiC)/TiAl functionally gradient materials by gas-pressure combustion sintering process. (1990)

Fabrication of (MoSi2-SiC