gebhart/patrepeval huggingface dataset:
Virtuoso: Massive Multilingual Speech-Text Joint Semi-Supervised Learning for Text-To-Speech (2022)

This paper proposes Virtuoso, a massively multilingual speech-text joint semi-supervised learning framework for text-to-speech synthesis (TTS) models. Existing multilingual TTS typically supports tens of languages, which are a small fraction of the thousands of languages in the world. One difficulty to scale multilingual TTS to hundreds of languages is collecting high-quality speech-text paired data in low-resource languages. This study extends Maestro, a speech-text joint pretraining framework for automatic speech recognition (ASR), to speech generation tasks. To train a TTS model from various types of speech and text data, different training schemes are designed to handle supervised (paired TTS and ASR data) and unsupervised (untranscribed speech and unspoken text) datasets. Experimental evaluation shows that 1) multilingual TTS models trained on Virtuoso can achieve significantly better naturalness and intelligibility than baseline ones in seen languages, and 2) they can synthesize reasonably intelligible and naturally sounding speech for unseen languages where no high-quality paired TTS data is available.
Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France (2022)

In the context of increasing antimicrobial resistance in Enterobacterales, the management of these UTIs has become challenging. We retrospectively assess the prevalence of antimicrobial resistance in Enterobacterales isolates recovered from urinary tract samples in France, between 1 September 2017, to 31 August 2018. Twenty-six French clinical laboratories provided the susceptibility of 134,162 Enterobacterales isolates to 17 antimicrobials. The most frequent species were <i>E. coli</i> (72.0%), <i>Klebsiella pneumoniae</i> (9.7%), <i>Proteus mirabilis</i> (5.8%), and <i>Enterobacter cloacae</i> complex (2.9%). The overall rate of ESBL-producing Enterobacterales was 6.7%, and ranged from 1.0% in <i>P. mirabilis</i> to 19.5% in <i>K. pneumoniae</i>, and from 3.1% in outpatients to 13.6% in long-term care facilities. Overall, 4.1%, 9.3% and 10.5% of the isolates were resistant to cefoxitin, temocillin and pivmecillinam. Cotrimoxazole was the less active compound with 23.4% resistance. Conversely, 4.4%, 12.9%, and 14.3% of the strains were resistant to fosfomycin, nitrofurantoin, and ciprofloxacin. However, less than 1% of <i>E. coli</i> was resistant to fosfomycin and nitrofurantoin. We identified several trends in antibiotics resistances among Enterobacterales isolates recovered from the urinary tract samples in France. Carbapenem-sparing drugs, such as temocillin, mecillinam, fosfomycin, cefoxitin, and nitrofurantoin, remained highly active, including towards ESBL-E.
Savoirs médicinaux interspécifiques et interactions entre cornacs et éléphants dans le district de Thongmyxay au Laos (2022)

Les cornacs du district de Thongmyxay au Laos et les éléphants forment une communauté hybride originale composée d'humains et d'une espèce animale représentée à la fois par des individus domestiques et sauvages. Nous avons étudié plus particulièrement les interactions entre l'observation des éléphants par les cornacs et leurs propres pratiques médicinales, humaines et ethnovétérinaires, qui ont fait l’objet de deux publications. À partir de ce matériel, complété par les données collectées sur le statut des éléphants domestiques de village et les interviews de quatre guérisseurs locaux, nous discutons ici dans une approche multispécifique associant données ethnographiques et connaissances éthologiques, les modalités de constructions et d’échanges possibles de savoirs médicinaux entre les deux espèces. Les éléphants ont un statut caractérisé par une double hybridité : sauvage et domestique d’une part, avec des circulations ontologiques d’un état à l’autre, et animal et humain d’autre part. Cette part d’humanité se traduit notamment par l’agentivité qui leur est reconnue dans l’aptitude à se soigner lorsqu’ils sont souffrants, et qui conduit à une utilisation thérapeutique de leurs crottins.Les cornacs intègrent dans leurs soins ethnovétérinaires des plantes dont ils observent l'usage par les éléphants utiliser lorsqu'ils sont malades. Les usages médicinaux qu’ils font de certaines de ces plantes au sein de leur foyer correspondent davantage à leurs observations de ces comportements d'automédication qu'à l'utilisation de ces mêmes items par les guérisseurs locaux, suggérant des transferts de connaissances médicinales des éléphants vers les cornacs.Du fait qu'une partie des éléphants de village de Thongmyxay est toujours périodiquement relâchée et se retrouve au contact des congénères sauvages, l’espace de domestication constitue une interface entre les humains, la forêt et les éléphants sauvages et nous discutons inversement la possibilité de transferts de savoirs des cornacs vers les éléphants de villages à travers les soins ethnovétérinaires qu’ils reçoivent.Ces savoirs précieux pour la santé et le bien-être des humains et des éléphants au Laos sont menacés par la réduction du couvert forestier abritant les ressources utilisées et par la relocalisation des éléphants de village vers les centres à vocation touristique. Ainsi émerge la nécessité de penser la conservation de ces patrimoines immatériels que représentent les savoirs issus de communautés hybrides en termes de patrimoines interspécifiques, impliquant de prendre en compte avec la préservation des écosystèmes abritant les ressources mobilisées dans ces savoirs, le maintien de leur accès à toutes les populations (humaines et animales) qui les utilisent.
Molecular dynamics-derived rotamer libraries for d-amino acids within homochiral and heterochiral polypeptides (2018)

Computational resources have contributed to the design and engineering of novel proteins by integrating genomic, structural and dynamic aspects of proteins. Non-canonical amino acids, such as d-amino acids, expand the available sequence space for designing and engineering proteins; however, the rotamer libraries for d-amino acids are usually constructed as the mirror images of l-amino acid rotamer libraries, an assumption that has not been tested. To this end, we have performed molecular dynamics (MD) simulations of model host-guest peptide systems containing d-amino acids. Our simulations systematically address the applicability of the mirror image convention as well as the effects of neighboring residue chirality. Rotamer libraries derived from these systems provide realistic rotamer distributions suitable for use in both rational and computational design workflows. Our simulations also address the impact of chirality on the intrinsic conformational preferences of amino acids, providing fundamental insights into the relationship between chirality and biomolecular dynamics. While d-amino acids are rare in naturally occurring proteins, they are used in designed proteins to stabilize a desired conformation, increase bioavailability or confer favorable biochemical and physical attributes. Here, we present d-amino acid rotamer libraries derived from MD simulations of alanine-based host-guest pentapeptides and show how certain residues can deviate from mirror image symmetry. Our simulations directly model d-amino acids as guest residues within the chiral l-Ala and d-Ala pentapeptide series to explicitly incorporate any contributions resulting from the chiralities of neighboring residues.
Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. IV. Inhibition of programming for lysis by pharmacologic agents. (1980)

Abstract The mechanism of T cell-mediated cytolysis has previously been resolved into three successive steps: adhesion formation, programming for lysis, and killer cell-independent lysis. In the present report we have examined the effects of a variety of drugs on programming for lysis. Concanavalin A (Con A)-coated specific target cells were incubated with effector cells at 37°C in the absence of Ca++ so that adhesions could form under conditions that did not permit programming for lysis. Such adhesions were shown not to be detached by EDTA or by any of the drugs tested. After adhesion formation, Ca++ and the drug of interest were added to the cultures, and the amount of ensuing lysis was measured. The following drugs were found to block programming for lysis, either partially or completely: trypan blue, benzyl alcohol, lidocaine, dimethylsulfoxide, colchicine, cytochalasin B, dibutyryl cyclic AMP, sodium azide, heparin, and FPTP. Cytochalasin B, however, was shown to block programming for lysis with substantially less potency than adhesion formation. Attempts to demonstrate a sequence of inhibitable steps within programming for lysis were carried out with the following combinations of agents: all possible pairs of the four inhibitors EGTA, trypan blue, FPTP, and benzyl alcohol; EGTA and low temperature; EGTA and sodium azide plus 2-deoxy-D-glucose. No sequence of inhibitable steps was found. The possibility that many or most of the inhibitors studied in these experiments may impede programming for lysis by limiting the closeness of contact between effectors and targets is discussed.
Ring Expansion and Rearrangements of Rhodium(II) Azavinyl Carbenes (2012)

Wenn der Ring zu klein wird: Eine regioselektive und konvergente Methode für Ringerweiterung und Umlagerung von 1-Sulfonyl-1,2,3-triazolen unter Rhodium(II)-Katalyse und N2-Abspaltung zu substituierten Enaminonen und Olefinen wurde entwickelt (siehe Schema). Die Enaminon-Produkte können anschließend in verschiedene Heterocyclen und Ketonderivate umgewandelt werden, aus denen das Sulfonyltriazol spurlos verschwindet. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The role of the GH-IGF-I axis in the regulation of myocardial growth: from experimental models to human evidence (2000)

Journal Article The role of the GH-IGF-I axis in the regulation of myocardial growth: from experimental models to human evidence Get access S Fazio, S Fazio Department of Clinical Medicine, Cardiovascular and Immunological Science, University Federico II Medical School, 80131 Naples, Italy Correspondence should be addressed to S Fazio, Medicina Interna, Via S. Pansini 5, 80131 Napoli, Italy; Fax: +39 081 746 3199 Search for other works by this author on: Oxford Academic Google Scholar E A Palmieri, E A Palmieri Department of Clinical Medicine, Cardiovascular and Immunological Science, University Federico II Medical School, 80131 Naples, Italy Search for other works by this author on: Oxford Academic Google Scholar B Biondi, B Biondi Department of Clinical Medicine, Cardiovascular and Immunological Science, University Federico II Medical School, 80131 Naples, ItalyDepartment of Molecular and Clinical Endocrinology and Oncology, University Federico II Medical School, 80131 Naples, Italy Search for other works by this author on: Oxford Academic Google Scholar A Cittadini, A Cittadini Department of Clinical Medicine, Cardiovascular and Immunological Science, University Federico II Medical School, 80131 Naples, Italy Search for other works by this author on: Oxford Academic Google Scholar L Sacca L Sacca Department of Clinical Medicine, Cardiovascular and Immunological Science, University Federico II Medical School, 80131 Naples, Italy Search for other works by this author on: Oxford Academic Google Scholar European Journal of Endocrinology, Volume 142, Issue 3, March 2000, Pages 211–216, https://doi.org/10.1530/eje.0.1420211 Published: 01 March 2000 Article history Received: 16 June 1999 Accepted: 11 November 1999 Published: 01 March 2000
TS-1 coated mesocellular titano-silica foams as new catalysts for oxidation of bulky molecules (2003)

TS-1 coated Ti-MCF materials have been prepared by the coating procedure using a diluted clear gel solution containing primary TS-1 nano-crystal units. Various techniques such as BET, TEM, FTIR, 29Si MAS NMR were used to monitor the physico-chemical properties of these samples. The coated samples exhibit higher activity and H2O2 selectivity for 1-naphthol hydroxylation compared to those of the parent Ti-MCF and TS-1 samples. Furthermore, a high hydrothermal stability of the mesopore structure and the absence of any Ti leaching during reaction were observed for the coated samples. This could be due to the zeolitic nature and hydrophobicity of the coated samples mesopore surface.
Columbia Atypical Depression (1993)

We summarise a series of studies using a MAOI to help establish the validity of a subgroup of depressives referred to as atypical depressives. Patients with reactive mood meeting DSM-III criteria for depressive illness who had associated atypical features (which include hyperphagia, hypersomnolence, leaden paralysis, and rejection sensitivity) were randomised to imipramine, phenelzine and placebo. Non-responders were crossed over, and in all there were over 400 patient trials. Phenelzine consistently was found to be superior to imipramine. Only in trials which included patients lacking atypical, vegetative symptoms was imipramine found to equal phenelzine. We conclude that the researcher and the clinician should consider the relevance of the atypical depressive syndrome.
Lactate measurement by the capillary method in shocked patients (2008)

Arterial blood lactate is a reliable indicator of tissue oxygen debt and is of value in expressing the degree and prognosis of circulatory failure. Compared with arterial measurement, capillary lactate measurement is easier, faster, cheaper and lowers the incidence of arterial puncture complications. Capillary lactate measurement has been already validated to assess fetal well-being. The aim of this study was to compare arterial and capillary lactate in adult shocked patients.
Antiparkinsonian and anti-levodopa-induced dyskinesia effects obtained by stimulating the same site within the GPi in PD (1998)

Reply from the Authors: We thank Dr. Stanzione et al. for their comments and for reporting the results of two cases where DBS was applied in the GPi. In their patients, parkinsonian motor signs and LIDs were both improved by pallidal stimulation.

We have had similar therapeutic results and agree that the GPi can be proposed as a target for DBS. The main purpose of our study,1 however, was not to discuss the therapeutic issues of pallidal stimulation in patients with PD but to provide pathophysiologic information on this specific target. Briefly, using quadripolar …
ChemInform Abstract: Triterpenes Possessing an Unprecedented Skeleton Isolated from Hydrolyzate of Total Saponins from Gynostemma pentaphyllum. (2012)

Abstract Isolation, structure determination and cytotoxicity of five novel triterpenes, gypensapogenins A—D, (I)—(IIb), as well as glucopyranoside of gypensapogenin D (IIc), are described.
The Important Role of Tetrahedral Ti4+ Sites in the Phase Transformation and Photocatalytic Activity of TiO2 Nanocomposites (2008)

Highly photoactive, tetrahedral Ti4+ sites can be created, other than in zeolite cavities and on silica substrate, in mixed-phase TiO2 nanocomposites. The tetrahedral Ti4+ species was shown to be an intermediate formed during the thermally driven phase transformation from anatase to rutile.
4D digital holographic microscopy (2017)

Summary form only given. 4D Digital Holographic Microscopy (4D-DHM) is a new technique capable of performing 3D imaging of moving objects. 3D reconstruction is made from a single hologram, but is restricted to sparse objects that occupy only small part of the volume. For a sequence of holograms, 4D-DHM therefore performs 4D (x; y; z and t) imaging. 4D-DHM is well suited to image micro circulation, and has been validated imaging red blood cells circulating in a zebrafish embryo in vivo [1-3].The principle of the 4D DHM is illustrated by Fig. ( (a) . The setup is an upright microscope, which has been modified to perform Digital Holographic Microscopy (DHM) in transmission. The white light illumination is replaced by a laser, which is split in two beams of different directions. To perform holographic detection a reference arm (ELO field) is added on the detection side. The field E scattered by the object interferes with ELO, and a camera records sequences of frames. These frames are used to calculate the holograms, and to reconstruct in 3D the field scattered by the sample. By a proper analysis of this information, 3D images of the blood vessels, and 4D images of the moving red blood cells (RBCs) can be obtained see Fig,( (b) to (d).
A Self-Tuning Dynamic Voltage Scaled Processor Using Delay-Error Detection and Correction (2006)

In this paper, we present the implementation and silicon measurements results of a 64bit processor fabricated in 0.18mum technology. The processor employs a delay-error detection and correction scheme called Razor to eliminate voltage safety margins and scale voltage 120mV below the first failure point. It achieves 44% energy savings over the worst case operating conditions for a 0.1% targeted error rate at a fixed frequency of 120MHz
Small inverter-interfaced distributed energy resources for reactive power support (2011)

The use of small inverter-interfaced distributed energy resources for reactive power support is discussed. While the primary function of these resources is to deliver active power, they can also be used to provide reactive power, often identified as an ancillary service by a utility. Given the large and increasing number of small grid-connected inverters, the total reactive power that can be collectively provided under proper control is substantial. The paper discusses inverter configurations for reactive power production, and presents distributed control strategies that enable these resources to provide reactive power support.
Etude de la ene-cyclisation de trifluoromethylcetones -ethyleniques : acces a des systemes cycliques porteurs du groupe cf#3 (1993)

Cette these est consacree a l'etude de la carbonyl-ene-cyclisation de trifluoromethylcetones -ethyleniques dont nous avons montre les applications, beaucoup plus diversifiees qu'en serie non fluoree. Nous avons mis en evidence les differents types de la ene-cyclisation (type i, type ii, type iii). Cette etude a permis de preparer des systemes monocycliques de structures diverses (5, 6, 7 et 8 chainons) et des systemes bicycliques (serie decaline et hydrindane) trifluoromethyles. Ces reactions s'effectuent avec d'excellents rendements et un bon controle stereoselectif. Nous avons pu egalement engendrer des ene-cyclisations a partir de double liaisons mono- et 1,2-disubstituees, connues pour etre particulierement peu reactives. Enfin nous avons utilise le motif cocf#3 comme initiateur de reactions de dicyclisation. Ce qui a permis d'acceder a des systemes tricycliques trifluoromethyles, en particulier a un analogue du podocarpatriene avec un bon rendement et une bonne selectivite
SplitX (2013)

There is a growing body of research on mechanisms for preserving online user privacy while still allowing aggregate queries over private user data. A common approach is to store user data at users' devices, and to query the data in such a way that a differentially private noisy result is produced without exposing individual user data to any system component. A particular challenge is to design a system that scales well while limiting how much the malicious users can distort the result. This paper presents SplitX, a high-performance analytics system for making differentially private queries over distributed user data. SplitX is typically two to three orders of magnitude more efficient in bandwidth, and from three to five orders of magnitude more efficient in computation than previous comparable systems, while operating under a similar trust model. SplitX accomplishes this performance by replacing public-key operations with exclusive-or operations. This paper presents the design of SplitX, analyzes its security and performance, and describes its implementation and deployment across 416 users.
Stabilized Space-time FEM and its Applications to Free-surface Flows (2000)

We present parallel 3D finite element computations of unsteady, incompressible free-surface flows. The approach is based on the Deformable-Spatial-Domain / Stabilized Space-Time (DSD/SST) finite element formulation, which takes automatically into account the motion of the free surface. The free-surface height is governed by a kinematic free-surface condition, which is also solved with a stabilized formulation. The mesh update can be achieved with general or special-purpose mesh moving schemes. The general mesh update schemes describe the mesh as a fictitious solid material, subject to appropriate constitutive relations. These relations can take the form of linear elasticity, or more complex nonlinear equations. The parallel implementation based on MPI message-passing standard is fully portable, and have been demonstrated to be scalable on a range of architectures. Examples will include a 3D computation of a flow past a spillway of a dam. Key Words: Space-Time Methods, Free-Surface Flow, Parallel Computing 1.
ISOLATION BY DISTANCE IN THE ATLANTIC COD, GADUS MORHUA, AT LARGE AND SMALL GEOGRAPHIC SCALES (2001)

Genetic isolation by distance (IBD) has rarely been described in marine species with high potential for dispersal at both the larval and adult life-history stages. Here, we report significant relationships between inferred levels of gene flow and geographic distance in the Atlantic cod, Gadus morhua, at 10 nuclear restriction-fragment-length-polymorphism (RFLP) loci at small regional scales in the western north Atlantic region (< 1600 km) that mirror those previously detected over its entire geographic range (up to 7300 km). Highly significant allele frequency differences were observed among eight northwestern Atlantic populations, although the mean FST for all 10 loci was only 0.014. Despite this weak population structuring, the distance separating populations explained between 54% and 62% of the variation in gene flow depending on whether nine or 10 loci were used to estimate Nm. Across the species' entire geographic range, highly significant differences were observed among six regional populations at nine of the 10 loci (mean FST= 0.068) and seven loci exhibited significant negative relationships between gene flow and distance. At this large geographic scale, natural selection acting in the vicinity of one RFLP locus (GM798) had a significant effect on the correlation between gene flow and distance, and eliminating it from the analysis caused the coefficient of determination to increase from 17% to 62%. The role of vicariance was assessed by sequentially removing populations from the analysis and was found to play a minor role in contributing to the relationship between gene flow and distance at either geographic scale. The correlation between gene flow and distance detected in G. morhua at small and large spatial scales suggests that dispersal distances and effective population sizes are much smaller than predicted for the species and that the recent age of populations, rather than extensive gene flow, may be responsible for its weak population structure. Our results suggest that interpreting limited genetic differences among populations as reflecting high levels of ongoing gene flow should be made with caution.