gebhart/patrepeval huggingface dataset:
The third ‘CHiME’ speech separation and recognition challenge: Dataset, task and baselines (2015)

The CHiME challenge series aims to advance far field speech recognition technology by promoting research at the interface of signal processing and automatic speech recognition. This paper presents the design and outcomes of the 3rd CHiME Challenge, which targets the performance of automatic speech recognition in a real-world, commercially-motivated scenario: a person talking to a tablet device that has been fitted with a six-channel microphone array. The paper describes the data collection, the task definition and the baseline systems for data simulation, enhancement and recognition. The paper then presents an overview of the 26 systems that were submitted to the challenge focusing on the strategies that proved to be most successful relative to the MVDR array processing and DNN acoustic modeling reference system. Challenge findings related to the role of simulated data in system training and evaluation are discussed.
Surgical Outcomes of Endoscopic Endonasal Versus Transcranial Resection of Craniopharyngiomas (2020)

Domingo, Ricardo; Akinduro, Oluwaseun MD; Sandhu, Sukwinder; Lu, Victor M MS, PhD; Vivas-Buitrago, Tito MD; Herrera, Juan P; Chaichana, Kaisorn L MD; Quinones-Hinojosa, Alfredo MD Author Information
The Age-Precipitations Structure Of Al-Mg-Ge Alloy Aged At 473K (2015)

Abstract The Al-Mg-Ge alloy is one of the age-hardening aluminum alloy after solution heat treatment. It has been proposed that the age-precipitation behavior of Al-Mg-Ge alloy is different from that of Al-Mg-Si alloy according to our previous works about the microstructure on Al-Mg-Ge alloy over-aged at 523K. For example, The hardness of peak aged Al-1.0mass%Mg 2 Ge alloy is higher than that of Al-1.0mass%Mg 2 Si alloy. The precipitates in the over-aged samples have been classified as some metastable phases, such as the β ’-phase and Type-A precipitates and equilibrium phase of β -Mg 2 Ge by TEM observation. There a few reports about microstructure on Al-Mg-Ge alloys observed by TEM for different aging times. The age-precipitations structure of Al-Mg-Ge alloy has not been became clear. In this work, TEM observation was investigated the microstructure on Al-1.0mass%Mg 2 Ge alloy for difference aging times aged at 473K.
Selectivity estimation for predictive spatio-temporal queries (2004)

We propose a cost model for selectivity estimation of predictive spatio-temporal window queries. Initially, we focus on uniform data proposing formulae that capture both points and rectangles, and any type of object/query mobility combination (i.e., dynamic objects, dynamic queries or both). Then, we apply the model to nonuniform datasets by introducing spatio-temporal histograms, which in addition to the spatial, also consider the velocity distributions during partitioning. The advantages of our techniques are (i) high accuracy (1-2 orders of magnitude lower error than previous techniques), (ii) ability to handle all query types, and (iii) efficient handling of updates.
Near‐infrared light‐sensitive liposomes for enhanced plasmid DNA transfection (2016)

Near-infrared (NIR) light-responsive liposomes are attractive carriers for targeted and controlled drug delivery to the superficial organ or tissue (e.g., skin). This work describes the development of NIR-responsive liposomes by incorporating gold nanostars within liposomes composed of Phospholipon 90 g and cholesterol. Following cellular delivery, photothermal effect around the gold nanostar upon NIR stimulation induces microcavitation and liposome phase transition which consequently triggers the release of encapsulated molecules. Taking GFP plasmid as an example, we demonstrate enhanced gene transfection into fibroblasts following NIR treatment.
Performance of Sonication and Microfluidization for Liquid–Liquid Emulsification (1999)

The purpose of this research was to evaluate and compare liquid-liquid emulsions (water-in-oil and oil-in-water) prepared using sonication and microfluidization. Liquid-liquid emulsions were characterized on the basis of emulsion droplet size determined using a laser-based particle size analyzer. An ultrasonic-driven benchtop sonicator and an air-driven microfluidizer were used for emulsification. Sonication generated emulsions through ultrasound-driven mechanical vibrations, which caused cavitation. The force associated with implosion of vapor bubbles caused emulsion size reduction and the flow of the bubbles resulted in mixing. An increase in viscosity of the dispersion phase improved the sonicator's emulsification capability, but an increase in the viscosity of the dispersed phase decreased the sonicator's emulsification capability. Although sonication might be comparable to homogenization in terms of emulsification efficiency, homogenization was relatively more effective in emulsifying more viscous solutions. Microfluidization, which used a high pressure to force the fluid into microchannels of a special configuration and initiated emulsification via a combined mechanism of cavitation, shear, and impact, exhibited excellent emulsification efficiency. Of the three methodologies, sonication generated more heat and might be less suitable for emulsion systems involving heat-sensitive materials. Homogenization is in general a more effective liquid-liquid emulsification method. The results derived from this study can serve as a basis for the evaluation of large-scale liquid-liquid emulsification in the microencapsulation process.
1.1 to 1.6GHz distributed differential oscillator global clock network (2005)

A distributed differential oscillator global clock network using on-chip spiral inductors is designed in a 0.18 /spl mu/m 1.8V CMOS technology. The 2mm/spl times/2mm resonant clock network has a tank Q of 4.3, achieves more than an order of magnitude less jitter than a conventional non-resonant tree-driven-grid global clock network, and uses almost three times less power.
Abstract 2904: EGFR-targeted gold liposome for molecular imaging and therapy on NSCLC cells (2012)

Abstract Nanotechnologies are in development for monitoring drug delivery and therapeutic effect for cancer. However, tumor-targeted multifunctional nanoparticles for imaging of and therapy of lung cancer are not available. The Epidermal growth factor receptor (EGFR) is overexpressed in approximately 80% of non-small cell lung cancer (NSCLC) and is a target for novel therapeutics, however, the clinical results using EGFR inhibitors for NSCLC treatment had mixed results. These results indicate that EGFR expression or its mutational status is solely not a reliable marker to determine the outcome. Therefore, we have developed liposome (120nm) encapsulated with colloidal gold that are conjugated to therapeutic anti-EGFR antibodies (Katayama Chemical Industries Co. Ltd. Osaka, Japan) to determine the molecular specific imaging of NSCLC. The colloidal gold is used for optical imaging and the anti-EGFR antibody for therapy. In the present study, we investigated in vitro effect of these liposomes on EGFR-expressing (HCC827 and H1299) and EGFR-null (H520) NSCLC cells. EGFR-targeted liposome exhibited a strong antitumor effect on EGFR-expressing NSCLC cells. On the other hands, no significant growth inhibitory effects were observed on non-targeted liposome-treated cells. Intriguingly, treatment with EGFR-targeted liposome resulted in significantly higher cell death as compared with anti-EGFR antibody and liposome alone. Furthermore, reflected polarizing microscopy showed that the concentration of EGFR-targeted liposome bound to EGFR-expressing NSCLC cells increased, but EGFR-null cells did not. When EGFR was inhibited pharmacologically, the binding efficiency of EGFR-targeted liposome was attenuated on EGFR-expressing NSCLC cells. These findings indicate that EGFR-targeted liposome are selectively bound and delivered to EGFR expressing NSCLC cells but not the EGFR-null NSCLC cells. We are currently determining in vivo effect of EGFR-targeted liposome using subcutaneous HCC827 and H520 tumor models. Our findings demonstrated that EGFR-targeted liposome is a promising agent for therapy and molecular imaging of NSCLC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2904. doi:1538-7445.AM2012-2904
Visualization of a Guinea Pig T Lymphocyte Surface Component Cross-Reactive with Immunoglobulin (1978)

Thymus-derived lymphocytes (T cells) show exquisite specificity in recognition of antigens, but the nature of the cell surface receptor is controversial. Although antigen recognition mediated by immunoglobulin variable (V) regions remains the minimal hypothesis, it has been extremely difficult to definitely establish the presence of immunoglobulins on these cells. Chicken antibodies, produced against the (Fab')2fragment of mouse immunoglobulin G (IgG) and purified by binding to and elution from IgG-Sepharose 4B, bind to an endogenously synthesized surface component of guinea pig T cells. The binding occurred via a cross-reaction with murine k chain and a heavy chain determinant localized in the Fd region, and was visualized by immunofluorescence and immunoelectronmicroscopy using both transmission and scanning techniques. These data provide direct evidence for the presence of a surface component related to immunoglobulin on T lymphocytes.
A short stereocontrolled synthesis of hydroxyethylene dipeptide isosteres (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA short stereocontrolled synthesis of hydroxyethylene dipeptide isosteresD. Michael Jones, Bo Nilsson, and Michael SzelkeCite this: J. Org. Chem. 1993, 58, 8, 2286–2290Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/jo00060a052https://doi.org/10.1021/jo00060a052research-articleACS PublicationsRequest reuse permissionsArticle Views292Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Self-similar two-particle separation model (2007)

We present a new stochastic model for relative two-particle separation in turbulence. Inspired by material line stretching, we suggest that a similar process also occurs beyond the viscous range, with time scaling according to the longitudinal second-order structure function S2(r), e.g.; in the inertial range as ε−1∕3r2∕3. Particle separation is modeled as a Gaussian process without invoking information of Eulerian acceleration statistics or of precise shapes of Eulerian velocity distribution functions. The time scale is a function of S2(r) and thus of the Lagrangian evolving separation. The model predictions agree with numerical and experimental results for various initial particle separations. We present model results for fixed time and fixed scale statistics. We find that for the Richardson-Obukhov law, i.e., ⟨r(t)2⟩=gεt3, to hold and to also be observed in experiments, high Reynolds numbers are necessary, i.e., Reλ&amp;gt;O(1000), and the integral scale needs to be large compared to initial separation, i.e., L∕r0&amp;gt;30 and d∕L&amp;gt;3 need to be fulfilled, where d is the size of the field of view. Removing the constraint of finite inertial range, the model is used to explore separation dynamics in the asymptotic regime. As Reλ→∞, the distance neighbor function takes on a constant shape, almost as predicted by the Richardson diffusion equation. For the Richardson constant we obtain that g→0.95 as Reλ→∞. This asymptotic limit is reached at Reλ&amp;gt;1000. For the Richardson constant g, the model predicts a ratio of gb∕gf≈1.9 between backwards and forwards dispersion.
Image mirror symmetry density enabled by delay and coincidence detection in spiking neural networks (Conference Presentation) (2020)

Neuromorphic computing has made tremendous advances in computing efficiency by modeling computers after the brain primarily by applying a spiking model of information. Spiking models inherently maximize efficiency in noisy environments by placing the energy of the signal in a minimal time. However, many neuromorphic computing models ignore time delay between nodes, choosing instead to approximate connections between neurons as instantaneous weighting. With this assumption, many complex time interactions of spiking neurons are lost. Here, we show that the coincidence detection property of a spiking-based feed-forward neural network enables mirror symmetry. Testing this algorithm exemplary on geospatial satellite image data sets reveals how symmetry density enables automated recognition of man-made structures over vegetation. We further demonstrate that the addition of noise improves feature detectability of an image through coincidence point generation.
Prognostic impact of pSTAT3 on overall survival (OS) in gastrointestinal (GI) cancers: Data from 3 phase 3, randomized controlled trials (RCTs). (2021)

4147 Background: Retrospective studies of phosphorylated STAT3 (pSTAT3, a regulator of gene expression) in cancer-lineage cells have suggested it is a biomarker of poor prognosis. We analyzed data from 3 phase 3 RCTs (BRIGHTER [T1; NCT02178956], CO.23 [T2; NCT01830621], CanStem111P [T3; NCT02993731]) to evaluate the prognostic impact of pSTAT3 on OS in GI cancer patients (pts). Methods: pSTAT3 was evaluated in archival tumor tissue from pts with gastric or gastroesophageal junction adenocarcinoma (T1), colorectal cancer (T2), or pancreatic cancer (T3) who received standard of care in the control arms (CTL) of their respective trials. pSTAT3 positive (+) or negative (−) status was determined by detecting pSTAT3 in both tumor and tumor microenvironment (TME) cells in a laboratory-developed immunohistochemistry (IHC) assay (T1; T2), later developed into the investigational pSTAT3 IHC D3A7 assay (Agilent Technologies, Inc.) (T3). The positivity cutoff requires a sample have both a TME score of 2 and ≥5% of tumor cells staining positively for pSTAT3. Pre-analytical variables (eg, specimen collection, handling, and processing), tumor indication, and slight differences in the assays used for each study may contribute to relative differences in evaluable rates between studies. In an exploratory analysis, OS was compared in pSTAT3+ vs pSTAT3− pts via an unstratified log-rank test. Results: In each study, intent-to-treat pts with evaluable pSTAT3 results were considered pSTAT3-evaluable. This abstract includes pSTAT3-evaluable pts randomized to the CTL arms (T1: n/N=248/357, 69.5%; T2: n/N=110/144, 76.4%; T3: n/N=243/569, 42.7%). Baseline characteristics are presented in the table. Median (m) OS was shorter in pts with pSTAT3+ tumors across all studies (T1 hazard ratio [HR]=1.32 [95% confidence interval (CI): 1.00, 1.74]; T2 HR=2.40 [1.50, 3.83]; T3 HR=1.08 [0.77, 1.50]). Conclusions: In pSTAT3-evaluable populations from 3 RCTs across GI cancers, CTL pts with pSTAT3+ (vs pSTAT3−) tumors had shorter mOS. These results suggest that pSTAT3 positivity may be a biomarker of poor clinical outcome. Clinical trial information: NCT02178956; NCT01830621; NCT02993731. [Table: see text]
Determination of the intramolecular disulfide bond arrangement and biochemical identification of the glycosylation sites of the nonstructural protein NS1 of Murray Valley encephalitis virus (2001)

The 12 cysteine residues in the flavivirus NS1 protein are strictly conserved, suggesting that they form disulfide bonds that are critical for folding the protein into a functional structure. In this study, we examined the intramolecular disulfide bond arrangement of NS1 of Murray Valley encephalitis virus and elucidated three of the six cysteine-pairing arrangements. Disulfide linkages were identified by separating tryptic-digested NS1 by reverse-phase high pressure liquid chromatography and analysing the resulting peptide peaks by protein sequencing, amino acid analysis and/or electrospray mass spectrometry. The pairing arrangements between the six amino-terminal cysteines were identified as follows: Cys(4)-Cys(15), Cys(55)-Cys(143) and Cys(179)-Cys(223). Although the pairing arrangements between the six carboxy-terminal cysteines were not determined, we were able to eliminate several cysteine-pairing combinations. Furthermore, we demonstrated that all three putative N-linked glycosylation sites of NS1 are utilized and that the Asn(207) glycosylation site contains a mannose-rich glycan.
Abstract 4401: Antibody-mediated targeting of the uPA proteolytic activity neutralizes uPA functions in vivo (2010)

Abstract Urokinase-type plasminogen activator (uPA) plays a central role in tissue remodeling processes, during both normal physiological conditions and cancer progression. Most of our understanding of the role of uPA in vivo is derived from studies using gene-targeted uPA-deficient mice. To enable in vivo studies on the acute and specific interference with uPA functionality in adult mice, we have now developed murine monoclonal antibodies (mAbs) directed against murine uPA by immunization of uPA-deficient mice with the recombinant protein. Guided by ELISA, Western blotting, SPR and enzyme kinetic analyses, we have selected two highly potent and inhibitory anti-uPA mAbs (mU1 and mU3). Both mAbs recognize epitopes located on the B-chain of uPA that encompasses the catalytic site. In activity assays in vitro, mU1 blocked uPA-catalyzed plasminogen activation as well as plasmin-mediated pro-uPA activation, whereas mU3 only was directed against the first of these reactions. We provide evidence that acute disruption of uPA activity in the adult mouse was effective with mU1, but not mU3, because only mU1 rescued mice treated with a uPA-activable anthrax pro-toxin. Moreover, systemic administration of mU1 (i) delayed wound healing in tissue-type plasminogen activator (tPA)-deficient mice, and (ii) impaired uPA-mediated hepatic fibrinolysis in tPA-deficient mice, resulting in a phenotype mimicking that of uPA;tPA double-deficient mice. Importantly, these results demonstrate the specific antagonist-directed targeting of mouse uPA at the enzyme activity level in normal physiological processes in vivo. Preliminary results indicate that wild-type mice, which have been transplanted with murine Lewis lung carcinoma cells, display significant reduction in primary tumour growth, when treated with mU1 as compared to placebo-treated (i.e. PBS-treated) littermates. We thus suggest that mU1 is an excellent mAb candidate for therapeutic intervention studies in mouse cancer models. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4401.
Review of Waste Energy Resource in Vehicle Engine Exhaust (2012)

Energy recovery from vehicle engine exhaust has attracted considerable interest recently. Key parameters associated with the engine exhaust, including temperature, mass flow rate, maximum extractable energy, and optimum location for energy extraction all factor strongly into the materials research and device design for waste heat recovery. This review paper compiles available data in literature on the vehicle engine exhaust resources for several different vehicles, and under various operational conditions. Three vehicles types, namely, mid-size sedans, light duty trucks, and heavy duty trucks, have been considered, and the driving cycles including Federal Test Procedure (FTP) series, Highway Fuel Economy Test (HFET) and New European Driving cycle (NEDC) are considered in this review. The results show the average temperatures at highway driving cycle and city driving cycle remain in the ∼500–650°C and ∼200–400 °C range, respectively. The mass flow rate varies significantly with vehicle size. The available thermal power calculated based on the collected data is 3–10 kW.© 2012 ASME
While Tinkering With the β-Cell… Metabolic Regulatory Mechanisms and New Therapeutic Strategies (2002)

A common feature of the two major forms of human diabetes is the partial or complete loss of insulin secretion from beta-cells in the pancreatic islets of Langerhans. In this article, we review the development of a set of tools for studying beta-cell biology and their application to understanding of fuel-mediated insulin secretion and enhancement of beta-cell survival. Insights into these basic issues are likely to be useful for the design of new drug and cell-based diabetes therapies.
An Official American Thoracic Society Statement: Position Statement on ATS Activities for the Promotion of Respiratory and Sleep/Wake Health and the Care of the Critically Ill in the United States (2009)

The American Thoracic Society's Mission, Core Principles, and Vision provide clear guidance for the formulation of specific strategies that will serve to promote improved respiratory health and care of the critically ill in the United States.
APLA: Indexing Arbitrary Probability Distributions (2007)

The ability to store and query uncertain information is of great benefit to databases that infer values from a set of observations, including databases of moving objects, sensor readings, historical business transactions, and biomedical images. These observations are often inexact to begin with, and even if they are exact, a set of observations of an attribute of an object is better represented by a probability distribution than by a single number, such as a mean. In this paper, we present adaptive, piecewise-linear approximations (APLAs), which represent arbitrary probability distributions compactly with guaranteed quality. We also present the APLA-tree, an index structure for APLAs. Because APLA is more precise than existing approximation techniques, the APLA-tree can answer probabilistic range queries twice as fast. APLA generalizes to multiple dimensions, and the APLA-tree can index multivariate distributions using either one-dimensional or multidimensional APLAs. Finally, we propose a new definition of k-NN queries on uncertain data. The new definition allows APLA and the APLA-tree to answer k-NN queries quickly, even on arbitrary probability distributions. No efficient k-NN search was previously possible on such distributions.
Supplementary Figure 1 from Identification of Key Regions and Genes Important in the Pathogenesis of Sézary Syndrome by Combining Genomic and Expression Microarrays (2023)

Supplementary Figure 1 from Identification of Key Regions and Genes Important in the Pathogenesis of Sézary Syndrome by Combining Genomic and Expression Microarrays