gebhart/patrepeval huggingface dataset:
Morphine Antinociception Medullary Pain Modulating Neurons and Reduce Kappa Opioids Inhibit Physiologically Identified (2012)

[PDF] [Full Text] [Abstract] , January 1, 2006; 95 (1): 33-41. J Neurophysiol Wendy Kincaid, Miranda J. Neubert, Mei Xu, Chang Jae Kim and Mary M. Heinricher Role for Medullary Pain Facilitating Neurons in Secondary Thermal Hyperalgesia [PDF] [Full Text] [Abstract] , December 16, 2009; 29 (50): 15828-15835. J. Neurosci. Akiko Okada-Ogawa, Frank Porreca and Ian D. Meng Controls in Dura-Sensitive Medullary Dorsal Horn Neurons Sustained Morphine-Induced Sensitization and Loss of Diffuse Noxious Inhibitory [PDF] [Full Text] [Abstract] , August , 2011; 338 (2): 579-587. J Pharmacol Exp Ther and Kazuo Hanaoka Haihua Shu, Masakazu Hayashida, Hideko Arita, Wenqi Huang, Hui Zhang, Ke An, Guiyun Wu -Opioid Receptors in Mice κ Compromised by -Opioid Receptors and μ Pentazocine-Induced Antinociception Is Mediated Mainly by [PDF] [Full Text] [Abstract] , August , 2011; 106 (2): 731-740. J Neurophysiol Nigel P. Pedersen, Christopher W. Vaughan and MacDonald J. Christie the rostral ventromedial medulla in mice Opioid receptor modulation of GABAergic and serotonergic spinally projecting neurons of
Simulation for a Floating Roof Behavior of Cylindrical Storage Tank due to Wind Load: Part 1 — CFD Analysis (2012)

Floating roofs are used in large cylindrical storage tanks to prevent evaporation of oil. The floating roof is said to vibrate in high winds like undulation of the sea surface. The wind induced, sea-surface-undulation-like vibration may initiate fatigue cracks at welded joints in the floating roof deck. In this two-part study, the authors attempted to simulate the vibration. In Part1 wind flow over an isolated cylindrical oil-storage tank was simulated without considering the motion of the roof. Computed unsteady pressure load data were transferred to structural analyses. Response analyses of the floating roof under the wind load are dealt with in Part2. The present paper describes the wind flow simulation. The computed pressure fluctuation over the roof exhibits broadband spectra and no remarkable dominant frequency. To gain some insights into characteristics of the roof pressure fluctuation and its association with global flow structures, the Snapshot Proper Orthogonal Decomposition (POD), the Dynamic Mode Decomposition (DMD), and the Complex POD were applied.
Simulation of negative permittivity and negative permeability by means of evanescent waveguide Modes-theory and experiment (2005)

In this paper, the theoretical foundations of the equivalence between waveguide propagation below cutoff and artificial plasmas are carefully analyzed through the derivation of the propagation constants of normal modes in waveguides filled with anisotropic plasmas. The equivalence between waveguide and dielectric plasma proposed by Marquees et al., which is valid for evanescent TE modes, has a dual counterpart for magnetic plasmas and evanescent TM modes. This new equivalence states that a negative magnetic permeability medium can be simulated by means of TM modes below their cutoff frequencies. The need of an anisotropic filling of the waveguide for the equivalence between plasmas and evanescent modes is also highlighted. To exemplify the applicability of this new equivalence, a structure that implements a double-negative medium has been proposed. Full-wave simulations of the proposed structure and measurements from an experimental setup are presented, both of which corroborate the new equivalence's validity.
Dengue Vaccines Approach the Finish Line (2007)

The spread of dengue virus (DV) via its Aedes mosquito vector throughout most of the tropics has led to a worldwide resurgence of epidemic dengue, including dengue hemorrhagic fever. For the first time in 60 years, the pipeline of dengue vaccines looks promising. Strains of each of the 4 DV serotypes, attenuated by passage in tissue culture or by recombinant DNA technology, have been formulated into tetravalent vaccines and have entered successful phase 1 and 2 clinical trials in the United States and Southeast Asia. Antibody-dependent enhancement of wild-type DV infections by the vaccine represents a unique safety issue, which is under investigation. The Pediatric Dengue Vaccine Initiative (funded by the Bill and Melinda Gates Foundation), the World Health Organization, industry, the US military, and governments of tropical countries are collaborating to accelerate dengue vaccine development and phase 3 vaccine efficacy trials in countries where dengue is endemic. A protective tetravalent vaccine must be licensed soon if dengue is to be brought under control.
Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells (2010)

The mammalian target of rapamycin (mTOR) kinase is an important component of PTEN/PI3K/Akt signaling pathway, which is frequently deregulated in prostate cancer (CaP). Recent studies suggest that targeting PTEN/PI3K/Akt and mTOR signaling pathway could be an effective strategy for the treatment of hormone refractory CaP. Here, we show that the treatment of androgen-independent and PTEN-negative human CaP PC3 cells with fisetin, a dietary flavonoid, resulted in inhibition of mTOR kinase signaling pathway. Treatment of cells with fisetin inhibited mTOR activity and downregulated Raptor, Rictor, PRAS40 and GbetaL that resulted in loss of mTOR complexes (mTORC)1/2 formation. Fisetin also activated the mTOR repressor TSC2 through inhibition of Akt and activation of AMPK. Fisetin-mediated inhibition of mTOR resulted in hypophosphorylation of 4EBP1 and suppression of Cap-dependent translation. We also found that fisetin treatment leads to induction of autophagic-programmed cell death rather than cytoprotective autophagy as shown by small interfering RNA Beclin1-knockdown and autophagy inhibitor. Taken together, we provide evidence that fisetin functions as a dual inhibitor of mTORC1/2 signaling leading to inhibition of Cap-dependent translation and induction of autophagic cell death in PC3 cells. These results suggest that fisetin could be a useful chemotherapeutic agent in treatment of hormone refractory CaP.
Software-Defined HoneyNet: Towards Mitigating Link Flooding Attacks (2017)

In this paper, we present SDHoneyNet, a SDN based system which exposes fake topology to attackers. SDHoneyNet finds potential bottleneck links by computing the static metric, which is Betweenness Centrality (BC) of the network topology given by the SDN controller. It also calculates the dynamic metric, which is Consumed Bandwidth Rate (CBR) of each link by collecting OF's port statistics. It finds a minimum intersection set containing the nodes that have both high static and dynamic metrics. Then, SDHoneyNet deploys the honey topology where the node degree follows a power-law distribution, to mimic complex networks. We leverage software switches to easily build and deploy the honey topology. We implement the prototype of SDHoneyNet as an SDN application (2,000 lines of Java code) on the ONOS controller.
The Anterior Intercostal Artery Flap: Anatomical and Radiologic Study (2017)

The authors found that the intercostal perforator flap has a consistent vascularization. Computed tomographic angiography is less reliable than dissection in identifying the number of perforators. The authors' findings suggest that intercostal perforator flaps are reliable and consistent flaps for reconstruction of the upper trunk.
German psoriasis registry PsoBest: objectives, methodology and baseline data (2014)

Patients in PsoBest represent patients with a high burden of disease.
Damage formation and substitutionality in 75As++-implanted diamond (1991)

Rutherford backscattering spectrometry (RBS) has been used to study damage formation and substitutionality in synthetic diamonds implanted with 250-keV 75As++ at either 600 °C or room temperature. Lattice damage following implantation at 600 °C was substantially less than damage following room-temperature implantation and appears to be composed of a higher fraction of extended defects. A significant portion of the As implanted at 600 °C was found to be in substitutional lattice sites with substitutional fractions as high as 50%. Changing the ion flux by three orders of magnitude during high-temperature implantation had no effect on either residual damage or substitutionality as indicated by the RBS analysis.
Factors affecting the use of dietetic services by patients with diabetes mellitus (2001)

This study confirmed that many patients with diabetes do not make use of professional dietetic services, and has highlighted some of the routinely documented characteristics that are associated with use of dietetic services. There appears to be scope to improve uptake of dietetic services by patients with diabetes, and to investigate further individual factors that affect access and attendance.
Anti-signal recognition particle autoantibody ELISA validation and clinical associations (2014)

We developed a quantitative ELISA for detecting serum anti-SRP autoantibodies and validated the assay in myositis. Longitudinal assessment of SRP levels by ELISA may be a useful biomarker for disease activity.
Conductive surfaces with dynamic switching in response to temperature and salt (2015)

This work demonstrates polymer brushes grafted from conductive polymer films which display dynamic surface switching dependent on salt, temperature and electrode potential. The electroactivity presented by the conductive polymer and the responsiveness of the grafted brushes leads to an interface with multiple control parameters. Here, we demonstrate this concept by grafting of uncharged brushes of poly(ethylene glycol)methyl ether methacrylates from conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT), and observe a temperature- and salt-induced switch of brush conformation, and their effect on the electrochemistry of the material. The switching conditions can be tailored by copolymerizing monomers with different numbers of ethylene glycol units. In addition, these surfaces exhibit antifouling properties, leading to potential applications such as electrically-addressable biointerfaces.
Fragment‐based screening and hit‐based substructure search: Rapid discovery of 8‐hydroxyquinoline‐7‐carboxylic acid as a low‐cytotoxic, nanomolar metallo β‐lactamase inhibitor (2021)

Metallo-β-lactamases (MBLs) are zinc-containing carbapenemases that inactivate a broad range of β-lactam antibiotics. There is a lack of β-lactamase inhibitors for restoring existing β-lactam antibiotics arsenals against common bacterial infections. Fragment-based screening of a non-specific metal chelator library demonstrates 8-hydroxyquinoline as a broad-spectrum nanomolar inhibitor against VIM-2 and NDM-1. A hit-based substructure search provided an early structure-activity relationship of 8-hydroxyquinolines and identified 8-hydroxyquinoline-7-carboxylic acid as a low-cytotoxic β-lactamase inhibitor that can restore β-lactam activity against VIM-2-expressing E. coli. Molecular modeling further shed structural insight into its potential mode of binding within the dinuclear zinc active site. 8-Hydroxyquinoline-7-carboxylic acid is highly stable in human plasma and human liver microsomal study, making it an ideal lead candidate for further development.
Motion Planning for Assembly Task Partner Robot (2017)

Collaborative robots that are able to coexist with workers are in demand, hence many companies have developed these robots recently. In our laboratory, we have developed assembly task partner robots beforehand. These robots need to avoid collisions with workers moving in the shared workspace. We have carried out collision avoidance motion planning using the RRT algorithm within the space where time axis is added to the C-space of robot. However, there was an issue that computation cost was unstable due to the random nature of RRT algorism. Therefore, we tried stabilizing the computation cost by choosing sampling points from probabilistically collision-free area that is modeled using GMM.
Estimates of the Fourier Amplitude Decay of Electron Micrographs of Single Particles (2000)

Abstract Several structures of single particles have been resolved to 7-9 Å using electron cryomicroscopy. This field is now poised to make the next step, to near atomic (3-4 Å) resolution. Signal to noise ratio is the critical factor determining the amount of data required for a structural determination at higher resolution. When properly weighted, signal to noise ratio is additive as image data is averaged coherently, however, this relies on perfect alignment of the noisy images. Typical refinement algorithms require as high a signal to noise ratio as possible for accurate alignment. We report a method, which allows accurate, routine determination of signal to noise ratio and other image parameters, both for data quality assessment and microscope quality tracking. Figure la shows a typical 400 kV electron image of ice-embedded herpesvirus capsids. The incoherent sum of the Fourier transforms of particle images (Fig. lb) shows that the data contains information out to a resolution of 7 Å. When rotationally averaged, this power spectrum can be expressed as:
A New Model for Stratification of Treatment Intensity in Relapsed Pediatric Hodgkin Lymphoma (2020)

Introduction High-dose chemotherapy and autologous hematopoietic stem cell transplantation (AHSCT) are standard for most relapsed/refractory Hodgkin lymphoma (R/R HL). Although some do not require AHSCT for cure, there is no standard therapy or inclusion criteria for this group. The ongoing trial CheckMate CA209-744 (NCT02927769) tests a risk-stratified, response-based algorithm for patients aged 5-30 years with R/R HL. In it, LR patients who attain complete metabolic response to chemoimmunotherapy receive consolidative radiation but omit AHSCT. Low risk (LR) relapse is defined as relapse of stage IA, IIA 3-12 months from completing ≤3 cycles of chemotherapy or stage I, II, and IIIA relapsing >1 year from therapy completion. Standard risk (SR) relapse includes all other relapses and all patients with B symptoms or extranodal disease at relapse or relapse in a prior radiation field. To broaden the definition of LR R/R HL, we retrospectively investigated the overall survival (OS) of pediatric patients with R/R HL using two novel definitions of LR relapse.
Acrolein inhalation acutely affects the regulation of mitochondrial metabolism in rat lung (2022)

Exposure of the airways to cigarette smoke (CS) is the primary risk factor for developing several lung diseases such as Chronic Obstructive Pulmonary Disease (COPD). CS consists of a complex mixture of over 6000 chemicals including the highly reactive α,β-unsaturated aldehyde acrolein. Acrolein is thought to be responsible for a large proportion of the non-cancer disease risk associated with smoking. Emerging evidence suggest a key role for CS-induced abnormalities in mitochondrial morphology and function in airway epithelial cells in COPD pathogenesis. Although in vitro studies suggest acrolein-induced mitochondrial dysfunction in airway epithelial cells, it is unknown if in vivo inhalation of acrolein affects mitochondrial content or the pathways controlling this. In this study, rats were acutely exposed to acrolein by inhalation (nose-only; 0-4 ppm), 4 h/day for 1 or 2 consecutive days (n = 6/group). Subsequently, the activity and abundance of key constituents of mitochondrial metabolic pathways as well as expression of critical proteins and genes controlling mitochondrial biogenesis and mitophagy were investigated in lung homogenates. A transient decreasing response in protein and transcript abundance of subunits of the electron transport chain complexes was observed following acrolein inhalation. Moreover, acrolein inhalation caused a decreased abundance of key regulators associated with mitochondrial biogenesis, respectively a differential response on day 1 versus day 2. Abundance of components of the mitophagy machinery was in general unaltered in response to acrolein exposure in rat lung. Collectively, this study demonstrates that acrolein inhalation acutely and dose-dependently disrupts the molecular regulation of mitochondrial metabolism in rat lung. Hence, understanding the effect of acrolein on mitochondrial function will provide a scientifically supported reasoning to shortlist aldehydes regulation in tobacco smoke.
Data Warehouse Architecture – Leading the next generation Data Science (2020)

The present study emphasizes the importance of the data warehouse as an important tool to maintain both ancient and present data, The study provides insight into the significant components of data warehouse architecture with its specific usage in the information science domain. In recent year ears, there has been a rapid expansion of the applicative properties of data warehousing owing to its wage in mobile and other social media platforms, In the current scenario, there has been a gradual shift in big data science towards green computing to overcome the environmental issues which have resulted in establishing data centers. The centers are gaining impute importance across the global especially in countries like America which is technology0oriented and is serving to maintain long lasting working environments.
Spectroscopy-on-chip applications of silicon photonics (2013)

In recent years silicon photonics has become a mature technology enabling the integration of a variety of optical and optoelectronic functions by means of advanced CMOS technology. While most efforts in this field have gone to telecom and datacom/interconnect applications, there is a rapidly growing interest in using the same technology for sensing applications, ranging from refractive index sensing to spectroscopic sensing. In this paper the prospect of silicon photonics for absorption, fluorescence and Raman spectroscopy on-a-chip will be discussed. To allow spectroscopy in the visible and near infrared the silicon photonics platform is extended with silicon nitride waveguides.
Classified comfort noise generation for efficient voice transmission (2006)

Comfort noise insertion during speech pause has been applied to Voice-over-IP and wireless networks for increasing bandwidth efficiency. We present two classified comfort noise generation (CCNG) schemes using Gaussian Mixture classifiers (GMM-C). Our first scheme employs a classified prototype background noise codebook with the prototype noise waveform chosen using a GMM-C. The second scheme utilizes a classified enhanced excitation codebook. The new CCNG algorithms provide better comfort noise during speech pauses and a smaller misclassification rate. We have retrofitted the scheme into existing speech transmission system, such as ITU-T G.711/Appendix II and G.723.1/Annex A. The perceived quality of a voice conversation of the novel system has been noticeably enhanced for car and babble noise. For the G.711 system, a large improvement is obtained for car noise while the largest amelioration is for babble noise in the G.723.1 system.
In vivo evaluation of antioxidant and anti-inflammatory activity of different extracts of date fruits in adjuvant arthritis. (2004)

)This study was carried out to evaluate the antioxidant and anti-inflammatory activity of methanolic and water extracts of the edible portion of date fruits (Phoenix dactylifera of date fruits (Phoenix dactylifera of date fruits ( L., Family Palmae) and methanolic extract of date seeds in adjuvant arthritis in rats, a model of chronic inflammation. Acute oral toxicity of the different extracts was carried out to determine their safety as functional foods. The results revealed that oral administration of the methanolic and aqueous extracts of edible portion of date fruits suppressed the swelling in the foot significantly by 67.8 and 61.3% respectively, while the methanolic extract of date seeds showed significant reduction by 35.5%. Antioxidant state (plasma vitamin C, E and A and β-carotene) increased significantly on administration of different extracts, while plasma level of MDA reduced significantly. Methanolic extract of edible portion of the fruit was the best in reducing foot swelling, ESR and plasma fibrinogen and in normalizing the plasma level of antioxidants. Adjuvant arthritic rats showed significant reduction in body weight gain and food efficiency ratio. Administration of any of the extracts produced significant increase in body weight gain and food efficiency ratio. Acute lethal toxicity test showed that the safest extract was the methanolic of edible portion of the fruit followed by the water extract that showed complete safety up to 6 g/kg mice weight. Methanolic extract of the seed showed LD50 equal to 6.75 g/kg mice.
The Vaginal Virome—Balancing Female Genital Tract Bacteriome, Mucosal Immunity, and Sexual and Reproductive Health Outcomes? (2020)

Besides bacteria, fungi, protists and archaea, the vaginal ecosystem also contains a range of prokaryote- and eukaryote-infecting viruses, which are collectively referred to as the "virome". Despite its well-described role in the gut and other environmental niches, the vaginal virome remains understudied. With a focus on sexual and reproductive health, we summarize the currently known components of the vaginal virome, its relationship with other constituents of the vaginal microbiota and its association with adverse health outcomes. While a range of eukaryote-infecting viruses has been described to be present in the female genital tract (FGT), few prokaryote-infecting viruses have been described. Literature suggests that various vaginal viruses interact with vaginal bacterial microbiota and host immunity and that any imbalance thereof may contribute to the risk of adverse reproductive health outcomes, including infertility and adverse birth outcomes. Current limitations of vaginal virome research include experimental and analytical constraints. Considering the vaginal virome may represent the missing link in our understanding of the relationship between FGT bacteria, mucosal immunity, and adverse sexual and reproductive health outcomes, future studies evaluating the vaginal microbiome and its population dynamics holistically will be important for understanding the role of the vaginal virome in balancing health and disease.
Innate Immune Responses in NF-κB-Repressing Factor-Deficient Mice (2005)

NF-kappaB-repressing factor (NRF) is a transcriptional silencer protein that specifically counteracts the basal activity of several NF-kappaB-dependent promoters by direct binding to specific neighboring DNA sequences. In cell culture experiments, the reduction of NRF mRNA leads to a derepression of beta interferon, interleukin-8, and inducible nitric oxide synthase transcription. The X chromosome-located single-copy NRF gene is ubiquitously expressed and encodes a protein of 690 amino acids. The N-terminal part contains a nuclear localization signal, the DNA-binding domain, and the NF-kappaB-repressing domain, while the C-terminal part is responsible for double-stranded RNA binding and nucleolar localization. To study the function of NRF in a systemic context, transgenic mice lacking the NRF gene were created. Against predictions from in vitro experiments, mice with a deletion of the NRF gene are viable and have a phenotype that is indistinguishable from wild-type mice, even after challenge with different pathogens. The data hint towards an unexpected functional redundancy of NRF.
Incorporation of guanidinium ions in CuII-[MV(CN)8]3− double-layered magnetic systems (2013)

The incorporation of guanidinium ions (Hgua+) in Cu(II)–M(V) systems results in the formation of two isostructural coordination polymers (Hgua)Cu(II)[M(V)(CN)8], M = W (1); Mo (2), which reveal a double-layered structure separated by guanidinium ions. The magnetic measurements reveal long range magnetic ordering with critical temperatures of 32.8 and 27.5 K for 1 and 2, respectively. Moreover, both assemblies exhibit hysteresis loops with coercive fields of 300 Oe for 1 and 50 Oe for 2, and a spin-flip transition around 120 Oe.