gebhart/patrepeval huggingface dataset:
The Contribution of Frictional Torque to Loosening at the Cement-Bone Interface in Tharies Hip Replacements* (1996)

We evaluated the results in a series of 170 osteoarthrotic hips (156 patients) at a median of 10.0 years (range, 3.0 to 16.4 years) after a Tharies resurfacing arthroplasty performed with cement. Our purpose was to assess the role of frictional torque in loosening at the cement-bone interface. The hips were divided into three groups on the basis of the diameter of the bearing surface: small (thirty-six, thirty-nine, or forty-three millimeters), medium (forty-seven millimeters), and large (fifty-one or fifty-four millimeters). Comparisons were made with Kaplan-Meier survivorship analysis, with stepwise discriminant analysis of risk factors for aseptic loosening. Revision for aseptic loosening was the end point for survivorship analysis. Despite higher frictional torques due to the increased diameter of the bearing surface and the increased average load, the larger prostheses survived significantly longer than the smaller ones (p=0.002). Stepwise covariate discriminant analysis indicated that the size of the bearing surface was the only factor identified that significantly affected survival. In six patients who had had a bilateral surface replacement with a component of a different size in each hip, the smaller prosthesis always failed first (p=0.001), at an average of seventy-seven months; the larger prosthesis failed at an average of 113 months. Nine patients had had a bilateral replacement with components of the same size, and there was no significant difference in the durations of survival of the two prostheses. Analysis of radiographs and retrieved specimens indicated that, regardless of the size of the component, the mechanism of loosening on both the acetabular and the femoral side of this so-called double-cup replacement was progressive resorption of bone induced by polyethylene wear particles that compromised the fixation of the components. More time was required for the process to disrupt++ the larger fixation area of the larger components. These data indicate that frictional torque was not the primary factor in the loosening of these prostheses with a large bearing surface and that higher friction and frictional torques can be tolerated if the generation of wear debris is sufficiently limited. These findings may be important as alternatives to polyethylene bearing surfaces are investigated.
Aqueous One‐Pot Synthesis of Pyrazoles, Pyrimidines and Isoxazoles Promoted by Microwave Irradiation. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
A locus for a human hereditary cataract is closely linked to the gamma-crystallin gene family. (1987)

Within the human gamma-crystallin gene cluster polymorphic Taq I sites are present. These give rise to three sets of allelic fragments from the gamma-crystallin genes. Together these restriction fragment length polymorphisms define eight possible haplotypes, three of which (Q, R, and S) were found in the Dutch and English population. A fourth haplotype (P) was detected within a family in which a hereditary Coppock-like cataract of the embryonic lens nucleus occurs in heterozygotes. Haplotype P was found only in family members who suffered from cataract, and all family members who suffered from cataract had haplotype P. The absolute correlation between the presence of haplotype P and cataract within this family shows that the gamma-crystallin gene cluster and the locus for the Coppock-like cataract are closely linked [logarithm of odds (lod) score of 7.58 at its maximum at phi = 0]. This linkage provides genetic evidence that the primary cause of a cataract in humans could possibly be a lesion in a crystallin gene.
Highly Functionalized β‐Cyclodextrins by Solid‐Supported Synthesis (2018)

Using covalent capture, a high yielding selective mono-functionalization of heptakis-[6-deoxy-6-(2-aminoethylsulfanyl)]-β-CD with a 5-mercaptopentyl functional group has been achieved. Here, we demonstrate the immobilization of the mono-thiol functionalized β-CD on PEGA resin via a disulfide bond, enabling solid-phase elaboration of the remaining six primary amines. To showcase the potential of this method, the amines were elaborated to tripeptides through standard Fmoc-peptide chemistry. A small library of CD-tripeptide conjugates was generated which, when reduced from the solid support, could be tagged at the released thiol with an environmentally sensitive fluorophore. The resulting library of sensors showed potential for the differential sensing of various bile salts. The described methodology provides a rapid and versatile route to synthesize highly functionalized libraries of CD derivatives that may be tailored towards applications in sensing, catalysis, and multivalent displays.
Asymptomatic Corneal Staining Associated with the Use of Balafilcon Silicone-Hydrogel Contact Lenses Disinfected with a Polyaminopropyl Biguanide-Preserved Care Regimen (2002)

Practitioners who fit silicone-hydrogel contact lenses on a daily wear basis should be wary of the potential for certain PHMB-containing multipurpose care systems to invoke corneal staining. Switching to non-PHMB based regimens will eliminate this complication in most instances.
NON-ORAL POSTER 63: Can the Q-Tip Test Be Used to Identify Patients at High-Risk of Having Urethrolysis After Midurethral Sling? (2006)

Miller, J R.; Goldberg, R P.; Botros, S M.; Aschkenazi-Steinberg, S O.; Sand, P K. Author Information
Emergence and Future of Exsolved Materials (2021)

Abstract Supported nanoparticle systems have received increased attention over the last decades because of their potential for high activity levels when applied to chemical conversions, although, because of their nanoscale nature, they tend to exhibit problems with long‐term durability. Over the last decade, the discovery of the so‐called exsolution concept has addressed many of these challenges and opened many other opportunities to material design by providing a relatively simple, single‐step, synthetic pathway to produce supported nanoparticles that combine high stability against agglomeration and poisoning with high activity across multiple areas of application. Here, the trends that define the development of the exsolution concept are reviewed in terms of design, functionality, tunability, and applicability. To support this, the number of studies dedicated to both fundamental and application‐related studies, as well as the types of metallic nanoparticles and host or support lattices employed, are examined. Exciting future directions of research are also highlighted.
Cognitive reserve moderates the relationship between hippocampal volume and cognitive decline – but not gait decline (2022)

Abstract Background Cognitive reserve (CR) accounts for individual differences in the relationship between brain health and clinical status. Common proxies of CR include education, and physical and social leisure activities. Greater CR allows individuals to cope better with poor brain health, and thereby delay the onset of cognitive impairment and dementia. Yet, whether CR protects against age‐related gait and cognitive decline is not well‐understood. Here, we examined whether CR moderates the relationship between hippocampal volume (a common marker of brain health) and age‐related decline in gait and cognition. Method Data from 101 LonGenity participants without dementia ( M Age=79.33±6.09 years; 56% women) who had completed one MRI, and up to 3 years of follow‐up testing ( M follow‐up=1.83±0.54 years) was examined. Gait speed was assessed during normal pace walking. Cognition was assessed with 11 neuropsychological tests, and a global cognitive composite. CR proxies (from self‐report), included cognitive (years of education), physical (number of blocks walked per day), and social (volunteering, living with someone) activities. FreeSurfer 6.0 was used to obtain hippocampal volume from structural MRIs. Linear mixed‐effects models adjusted for sex, parental longevity, cognitive impairment, and comorbidities examined the relationship between hippocampal volume and age‐related gait and cognitive decline. Result Education moderated the relationship between hippocampal volume and decline in figure copy performance. The number of blocks walked per day moderated the relationship between hippocampal volume and decline in global cognition, Trail Making Test (TMT)‐A, TMT‐interference, digit symbol substitution and phonemic fluency performance. Living with someone moderated the relationship between hippocampal volume and decline in global cognition, TMT‐interference, and logical memory performance. None of the CR proxies moderated the relationship between hippocampal volume and gait speed decline. Conclusion Cognitive, physical, and social CR proxies moderated the relationship between hippocampal volume and age‐related cognitive decline – not age‐related gait decline. Follow‐up sensitivity analyses, however, suggested that some CR proxies (e.g. education) moderated the relationship between prefrontal volumes and age‐related gait decline – presumably because prefrontal regions are more consistently associated with gait speed. Future studies are need to confirm whether the relationship between CR and age‐related gait and cognitive decline depends on the brain health marker.
Incident Response: Investigating Computer Crime (2001)

From the Publisher:
This is one of the first books available that explains what to do after you've been hacked. Written by FBI insiders,this book reveals the computer forensics process and offers authoritative solutions designed to counteract and conquer hacker attacks. 
Learn secrets and strategies for recovering from computer crime incidents Respond to security breaches and hacker attacks the right way with help from this insightful and practical guide. You'll get details on the entire computer forensic process and learn the importance of following specific procedures immediately after a computer crime incident occurs. Investigate various software including UNIX,Windows NT,Windows 2000,and application servers. Packed with technical examples and loads of how-to scenarios,this book will show you how to recognize unauthorized access,uncover unusual or hidden files,and monitor Web traffic. Detailed,authoritative,and up to dateIncident Response is the only book you need. 

Plan and prepare for all stages of an investigationincluding detection,initial response,management interaction,and more Learn the importance of evidence handling and storage Perform a trap and trace and learn network protocols Monitor network traffic and detect illicit servers and covert channels Investigate Web server attacks,DNS attacks,and router attacks
The therapeutic potential of inhibitors of the signal transducer and activator of transcription 3 for central nervous system malignancies (2011)

Given their direct antitumor cytotoxic effects, STAT3 inhibitors may exert therapeutic activity in the monotherapy setting but may also have compelling use as immunotherapeutic modulators or as a salvage therapy.
Multiscale visualization using data cubes (2003)

Most analysts start with an overview of the data before gradually refining their view to be more focused and detailed. Multiscale pan-and-zoom systems are effective because they directly support this approach. However generating abstract overviews of large data sets is difficult, and most systems take advantage of only one type of abstraction: visual abstraction. Furthermore, these existing systems limit the analyst to a single zooming path on their data and thus a single set of abstract views. This paper presents: (1) a formalism for describing multiscale visualizations of data cubes with both data and visual abstraction, and (2) a method for independently zooming along one or more dimensions by traversing a zoom graph with nodes at different levels of detail. As an example of how to design multiscale visualizations using our system, we describe four design patterns using our formalism. These design patterns show the effectiveness of multiscale visualization of general relational databases.
At the Edge (2002)

Here lies the vocation of those who preserve our understanding of past theories, who sharpen our sense of the subtle, complex interplay between political experience and thought, and who preserve our memory of the agonizing efforts of intellect to restate the possibilities and threats posed by political dilemmas of the past. —Sheldon S. Wolin, “Political Theory as a Vocation” In the same way in which the great transformation of the first industrial revolution destroyed the social and political structures as well as the legal categories of the ancien regime, terms such as sovereignty, right, nation, people, democracy, and general will by now refer to a reality that no longer has anything to do with what these concepts used to designate—and those who continue to use these concepts uncritically literally do not know what they are talking about. —Giorgio Agamben, Means without Ends: Notes on Politics Looking obliquely at the edges of things, where they come together with other things, can tell you as much about them, often, as can looking at them directly, intently, straight on. —Clifford Geertz, “The Near East in the Far East”
PCR Detection of Babesia ovata from Cattle Reared in Japan and Clinical Significance of Coinfection with Theileria orientalis (2012)

We describe here the clinical significance of coinfection with Theileria orientalis and Babesia ovata in cattle. Anemia status in a herd of dairy cattle in Japan was investigated in relation to infection with these parasites. Our findings indicate that while B. ovata infection might not be the primary cause of anemia in the cattle, it may contribute to the clinical development of anemia in animals coinfected with both B. ovata and T. orientalis.
An integrated intelligent decision support system based on sensor and computer networks (2017)

This chapter presents a general framework of IDSS-SC, an intelligent decision support system that integrates both sensing and computing subsystems. The structure of IDSS-SC is divided into three logical components: sensing field covered by wireless sensor networks, cyberspace based on computer networks, and command control center for intelligent decision making. The general framework of IDSS-SC we proposed integrates novel solutions in the aforementioned areas such as sensor deployment, data routing, network mapping, and information fusion for intelligent decision support. The application domains of IDSS-SC span from military operations, home-land and global security defense, to environment monitoring. One practical goal of sensor deployment in the design of distributed sensor systems is to achieve an optimal monitoring and surveillance of a target region. IDSS-SC aims at integrating the physical world and the cyberspace into a global self-organizing information space through the emerging sensor and computer science technologies.
Solving integral equations with inverse-designed metagratings at optical wavelengths (2021)

Inverse designed metasurfaces can solve prescribed Fredholm integral equations at optical wavelengths. To this end, a mirror is included to provide the feedback required to perform the Neumann series that solves the equation.
On the sound sources of screech tones radiated from choked circular jets (2001)

The generation mechanism of the screech tone in the helical oscillation mode is mainly investigated using a series of instantaneous schlieren photographs. From the photographs, five evanescent sound sources are observed as prominent points along the jet axis. The sound source for the dominant helical oscillation mode is found to be the second prominent point which moves along a circular orbit in a plane perpendicular to the jet axis and just downstream of the rear edge of the third shock cell. It is shown that the speed of a moving sound source is supersonic and that the Mach cone generated by the moving sound source forms the helical-shaped wave front of the screech tone for the helical oscillation mode of the jet. This idea of the moving sound source is well supported by a measured directionality of the screech tone. Sound sources of the other oscillation modes appearing in the other pressure ratio ranges are also described.
A Ka-Band CW 15.5W 15.6% Fractional Bandwidth GaN Power Amplifier MMIC Using Wideband BPF Inter-stage Matching Network (2019)

This paper has reported a Ka-band 15.5W power amplifier Monolithic Microwave Integrated Circuit (MMIC) using 0.15μm Gallium Nitride (GaN) HEMT with 15.6% fractional bandwidth. To realize a wideband power amplifier in Ka-band, a wideband band-pass filter (BPF) inter-stage matching network (ISMN) consists of the equivalent circuit parameters of inter-stage transistors is proposed. As a result, the fabricated 3-stage single-ended power amplifier MMIC using GaN-HEMT achieves a measured saturation output power (Psat) of 41.9 - 42.2dBm (15.5-16.6W) and peak power added efficiency (PAE) of 16.1 - 20.3% over 15.6% bandwidth in 26.5-31GHz under Continuous Wave (CW) operation. To the best of author's knowledge, that 15.5W output power with 15.6% bandwidth is state-of-the art for GaN power amplifier MMIC under CW operation in Ka-band.
Augmentation procedures using bone substitute materials or autogenous bone - a systematic review and meta-analysis. (2014)

Within the limitation of the meta-analytical approach taken, implant survival seems to be independent of the biomaterial used in MSFA and alveolar ridge augmentation. Therefore, based on the current literature, there is no evidence that AB is superior to BSM. The conclusions are limited by the fact that influence of defect size, augmented volume and regenerative capacity of the defects is not well described in the respective literature.
Abstract 1008: Cell density-related variability in chemotherapeutic resistance patterns in human cancer cells (2022)

Abstract Assessment of chemosensitivity and resistance varies with cancer cell of origin, drug and culture conditions. However, it is also not uncommon to find multiple different IC50 values for the same chemotherapeutic treatments acting on the same tumor cell lines. The aim of this research was to investigate this discrepancy in phenotypes and elucidate relevant variables that influence them. We assessed chemosensivity as a function of tumor cell density by plating TOV-21G ovarian, HT29 colorectal, and U2OS osteosarcoma cell lines in 96-well plates at various seeding densities per well and treated them with various concentrations of cisplatin, 5-fluorouracil (5-FU), and etoposide, respectively. CellTiter Glo assays were performed at 72 hours of treatment to determine IC50. Cisplatin IC50 for TOV-21G cells plated at 50,000, 20,000, 10,000, 5,000, 2,000, 1,000, and 500 cells/well were 12.00 μM, 5.47 μM, 3.16 μM, 2.45 μM, 2.54 μM, 2.83 μM, and 2.66 μM, respectively. Etoposide IC50 for U2OS cells plated at the same seeding densities were 6.50 μM, 5.19 μM, 3.23 μM, 2.98 μM, 2.49 μM, 2.13 μM, and 1.88 μM, respectively. IC50 values for HT29 cells treated with 5-FU at 2,000, 1,000, and 500 cells/well were 35.89 μM, 19.74 μM, and 13.42 μM, respectively. TOV-21G, U2OS, and HT29 cells all showed differences in IC50 values depending on cell plating density. TOV-21G and U2OS cells both showed a gradual decrease and plateau in IC50 as the cancer cell density decreased from 50,000 cells/well to 500 cells/well. HT29 cells displayed a sharper IC50 decrease as the cell density decreased from 2,000 cells/well to 500 cells/well. Our experiments demonstrate that IC50 values are not static at 72 hours and that tumor cell density is an important variable in influencing observed tumor resistance to traditionally effective drugs. As the density of cancer cells increases, the cells develop more resistance to the associated chemotherapy and require higher quantities of drug to achieve the same level of growth inhibition. We are currently exploring underlying molecular mechanisms that may influence these changes in IC50 including cell survival signaling proteins, cell-cell contact or growth factors that may influence cell density-related chemoresistance. Citation Format: Thomas Brown, Ujwal Punyamurtula, Jill Strandberg, Wafik S. El-Deiry. Cell density-related variability in chemotherapeutic resistance patterns in human cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1008.
Discovery of peptide probes to modulate oxytocin-type receptors of insects (2018)

The oxytocin/vasopressin signalling system is conserved across the animal kingdom. In insects, the role of oxytocin-type (inotocin) neuropeptides has only been studied in locusts, beetles and ants, but their physiology continues to be poorly understood. One reason for this knowledge deficit is the lack of available research tools to complement functional genomics efforts. Consequently, ligands to probe insect inotocin receptors are essential. In this study, we sought to identify novel agonists and antagonists of the inotocin receptor from the representative model species Tribolium castaneum and Lasius niger. Drawing upon known ligands of the human receptors, we examined the pharmacology of the plant-derived cyclotide kalata B7 and the synthetic oxytocin analogue atosiban. Kalata B7 is a weak partial agonist of both inotocin receptors. This is the first reported direct interaction of cyclotides with an insect receptor, an observation that may explain their presumed role in herbivore defence. Furthermore, we discovered atosiban is an antagonist of the Tribolium receptor, which may provide a useful probe to investigate the functionality of inotocin signalling in beetles and related insect species. Our findings will enable further examination of insect inotocin receptor pharmacology and physiology, and may trigger studies to comprehend the interaction of plant cyclotides and insects.
GEN01-5: Adaptive Linear Precoded DMT as an Efficient Resource Allocation Scheme for Power-Line Communications (2006)

In this paper, we propose to apply adaptive loading principles to linear precoded digital multitone (LP-DMT). This new approach can especially be exploited in the powerline context, since it requires the knowledge of the channel at the transmitter. We first show that maximal waveform capacity is achieved when orthogonal matrices are used to linearly precode the multitone signal. A practical loading algorithm based on tone clustering is then developed to handle the configuration of the system. This algorithm assigns tones, size of preceding matrices, bits and energies in order to maximize the total throughput of the system. The optimization procedure is led under power spectral density (PSD) limitations and finite order modulations constraint. Through simulations over power line channels, it is shown that the new adaptive LP-DMT system takes advantage of the carrier merging effect offered by the precoding function and then outperforms the non-precoded DMT system.