gebhart/patrepeval huggingface dataset:
Phase 1/dose expansion trial of brentuximab vedotin and lenalidomide in relapsed or refractory diffuse large B-cell lymphoma (2021)

New therapies are needed for patients with relapsed/refractory (rel/ref) diffuse large B-cell lymphoma (DLBCL) who do not benefit from or are ineligible for stem cell transplant and chimeric antigen receptor therapy. The CD30-targeted, antibody-drug conjugate brentuximab vedotin (BV) and the immunomodulator lenalidomide (Len) have demonstrated promising activity as single agents in this population. We report the results of a phase 1/dose expansion trial evaluating the combination of BV/Len in rel/ref DLBCL. Thirty-seven patients received BV every 21 days, with Len administered continuously for a maximum of 16 cycles. The maximum tolerated dose of the combination was 1.2 mg/kg BV with 20 mg/d Len. BV/Len was well tolerated with a toxicity profile consistent with their use as single agents. Most patients required granulocyte colony-stimulating factor support because of neutropenia. The overall response rate was 57% (95% CI, 39.6-72.5), complete response rate, 35% (95% CI, 20.7-52.6); median duration of response, 13.1 months; median progression-free survival, 10.2 months (95% CI, 5.5-13.7); and median overall survival, 14.3 months (95% CI, 10.2-35.6). Response rates were highest in patients with CD30+ DLBCL (73%), but they did not differ according to cell of origin (P = .96). NK cell expansion and phenotypic changes in CD8+ T-cell subsets in nonresponders were identified by mass cytometry. BV/Len represents a potential treatment option for patients with rel/ref DLBCL. This combination is being further explored in a phase 3 study (registered on https://clinicaltrials.org as NCT04404283). This trial was registered on https://clinicaltrials.gov as NCT02086604.
Intense Blue Fluorescence in a Leucine Zipper Assembly (2011)

Fluorescence switching of 7-diethylaminocoumarin-3-carboxylic acid (DEAC) from a dark state to bright blue was achieved through the formation of a 3α-helical bundle structure. The DEAC unit in the leucine zipper assembly showed fluorescence 50 times stronger than that of the DEAC unit alone. The stable 3α-helical bundle structure was essential for the great enhancement of the DEAC fluorescence.
Transfer-Learning-Assisted Multielement Calibration for Active Phased Antenna Arrays (2022)

A transfer-learning-based method for accelerating power-only calibration of phased array antennas by combining the conventional array theory with deep learning is presented in this communication. The existing power-only calibration methods either require a significant number of measurement cycles or have restrictive phase shifter resolution requirements. The proposed array calibration method uses a surrogate model to calibrate all the array elements in one pass without restricting phase resolution requirements. We developed a novel feature extraction scheme (FES) that picks out the most important power features resulting in reduced measurement cycles. The burden of data acquisition for model training is further reduced by relational knowledge transfer learning. The surrogate model acquires its general calibration capability from massive theoretical data, which is easily collected by the radiation multiplication theorem, and captures the detailed nonideal response from a small number of simulations. The proposed methodology has been demonstrated and tested on several arrays for validation. The effectiveness and performance of the method have been verified, and hence, it can serve as a complementary tool to accelerate the calibration process of phased antenna arrays.
Polymethylmethacrylate Membrane and Serum Free Light Chain Removal: Enhancing Adsorption Properties (2013)

PMMA membranes can efficiently adsorb sFLC, but the process is limited by membrane saturation and is different between κ and λ sFLC. The new EAD technique can greatly improve λ removal but only partially act on κ sFLC. Therefore, EAD should be considered a valid economic treatment option without side effects in particular subsets of patients for the removal of sFLC.
Nonvolatile Liquid-Film-Embedded Microfluidic Valve for Microscopic Evaporation Control Without Stiction Problem at Liquid–Air Interfaces (2012)

A critical problem of quick evaporation speed of fluids in the microscopic scale can cause many unexpected results and failures. Here, we introduce evaporation speed controlling effects of a thin liquid-film-based microfluidic valve in a microfluidic droplet ejector. The thin liquid film with nonvolatility and immiscibility exhibited an excellent microfluidic valve function without any stiction problem between valve components and provided a very effective evaporation protection barrier for the microfluids in the device. We have investigated its effectiveness for evaporation control at a microfluidic port with a liquid-air interface. Successful evaporation control by the liquid-film-embedded microfluidic valve has been demonstrated. We believe that this novel approach has immense potential in many microfluidic devices requiring a high level of evaporation control.
Null Test for a Highly Paraboloidal Mirror (2004)

A circular null computer-generated hologram (CGH) was used to test a highly paraboloidal mirror (diameter, 90 mm; f number, 0.76). To verify the null CGH test a classic autocollimation test with a flat mirror was performed. Comparing the results, we show that the results of the null CGH test show good agreement with results of the autocollimation test.
Quantitative Hydrogenation at 100-300 Atmospheres (1933)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative Hydrogenation at 100-300 AtmospheresHomer AdkinsCite this: J. Am. Chem. Soc. 1933, 55, 10, 4272–4279Publication Date (Print):October 1, 1933Publication History Published online1 May 2002Published inissue 1 October 1933https://pubs.acs.org/doi/10.1021/ja01337a068https://doi.org/10.1021/ja01337a068research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Las peripecias de Prometeo (2011)

Si en el mito de Prometeo el fuego representa la tecnologia y los numeros el intelecto, tenemos entonces una completa metafora sobre el conocimiento como elemento liberador; la liberacion de las mentes por la ciencia y las matematicas.
Cytological localization of chorionic gonadotropin alpha and placental lactogen mRNAs during development of the human placenta. (1982)

Probes derived from clones bearing cDNAs corresponding to the alpha subunit of human chorionic gonadotropin (hCG) and human placental lactogen (hPL) were used to localize their respective mRNAs cytologically in sections of first trimester and term human placenta. hPL mRNA was exclusively localized to the syncytial layer, hCG alpha mRNA was found in the syncytial layer and also in some differentiating cytotrophoblasts. Hybridization was specific because no signal was observed when labeled pBR322 was hybridized to placental sections or when the placental probes were hybridized to sections of human tonsils. In addition, RNA in placental interstitial cells did not hybridize with hCG alpha and hPL probes. Hybridization with the hCG alpha probe was much greater in first trimester than in term sections, whereas hPL signals were comparable in both first trimester and term placentae. Syncytial formation proceeds through cellular intermediates of cytotrophoblastic origin, and the data suggest that transcription of the hCG alpha gene is initiated before the completion of syncytial formation. In contrast, hPL mRNA synthesis starts later in trophoblast differentiation, likely after the stage of syncytial formation. The data also suggested that hCG alpha mRNA synthesis becomes attenuated but that hPL is transcribed at a rather constant rate during placental development.
Dielectric Properties of Insulating Silicone Rubber due to Frequency Variation (1993)

The dielectric properties of silicone rubbers are very important to investigate the polymer structure. The characteristics of the dielectric absorption in silicone rubbers were studied in the frequency range of 30Hz to at the temperature range of through . As the results of the study, dielectric constant, tangent 5 were measured .
The Breathing Gut – CO2-Elimination über den Darm (2023)

Für die Behandlung der hyperkapnischen respiratorischen Insuffizienz wäre eine alternative Austauschfläche für Kohlendioxid wünschenswert, da die Behandlung eine Herausforderung bleibt: die chronische Therapie mittels nichtinvasiver Beatmung ist mit Problemen bei der Patientencompliance behaftet, während die akute Behandlung mittels Beatmung und extrakorporalen Verfahren mit vielfältigen Komplikationen einhergeht.
PAR-Constrained Multiuser MIMO OFDM based on Convex Optimization and Concentration of Measure. (2016)

In multi-user multiple-input multiple-output (MU-MIMO) orthogonal frequency division multiplexing systems, a block diagonalization (BD) precoding scheme is first designed to aim at minimizing the peak-to-average power ratio (PAR) for a fixed cost, which is a sum of the received SNR loss of users. Then the BD precoder is designed to provide the required PAR at the minimum cost, which is our main goal. By the aid of the concentration of measure property, it is almost exactly able to provide the required PAR on average, and also provide the required performance specified as 0.1 percent PAR in an asymptotic way.
Mitigating prolonged QT interval in cancer nanodrug development for accelerated clinical translation (2013)

Here we show a curcumin encapsulated lipopolymeric hybrid nanoparticle formulation which could protect against QT prolongation and also render increased bioavailability and stability thereby overcoming the limitations associated with curcumin.
The role of stem cell factor (c-kit ligand) and inflammatory cytokines in pulmonary mast cell activation (1996)

Mast cells play a critical role in allergic airway responses via IgE-specific activation and release of potent inflammatory mediators. In the present study, we have isolated and characterized primary mast cell lines derived from the upper airways of normal mice. The primary mast cell lines were grown and maintained by incubation with interleukin-3 (IL-3) and stem cell factor (SCF) and shown to be c-kit (SCF receptor) positive by flow cytometry. Subsequently, we examined the proliferation of both airway and bone marrow derived mast cell lines in response to inflammatory and hematopoietic cytokines, including SCF, IL-1, IL-3, interferon-gamma, IL-4, and IL-10. The results from the pulmonary mast cell lines were compared with those from bone marrow derived mast cells. Pulmonary mast cell lines were capable of proliferating in response to IL-3, IL-4, IL-10, and SCF, whereas the combination of SCF with the other cytokines did not increase the response over SCF alone. In contrast, the bone marrow-derived mast cells proliferated strongest to SCF or IL-3, but only modestly to IL-4 and IL-10. Furthermore, the combination of SCF with IL-3, but not the other cytokines, exhibited an increase in bone marrow-derived mast cell proliferation. Cytokine-specific stimulation of histamine release in the airway-derived and bone marrow-derived mast cells showed parallel results. SCF was the only cytokine shown to induce substantial histamine release. However, when certain nonhistamine releasing cytokines were combined with SCF, a synergistic increase in histamine release was induced in upper airway, but not bone marrow-derived mast cells. The results of these studies suggest that cytokines differentially modulate induction of proliferation and degranulation of bone marrow and upper airway-derived mast cells and may further indicate a cytokine activational cascade in tissue mast cells.
Preterm births - United States, 2006 and 2010. (2013)

Approximately one third of all infant deaths in the U.S. are related to preterm birth. Infants who survive a preterm birth are at greater risk than those born later in pregnancy for early death and lifelong effects such as neurologic and cognitive difficulties. The rate of preterm births (i.e., <37 completed weeks' gestation) increased approximately 30% during 1981-2006. In 2007, this trend began to reverse; the U.S. preterm birth rate decreased for the fourth consecutive year in 2010, decreasing from the 2006 high of 12.8% to 12.0% in 2010. A total of 4,265,555 births were reported for 2006, including 542,893 preterm births, and 3,999,386 births were reported for 2010, including 478,790 preterm births. Although most of the recent decrease in this rate was among infants born at 34 to 36 weeks' gestation (i.e., late preterm), with a decrease from 9.15% to 8.49% during 2006-2010, the rate of infants born at <34 weeks' gestation (i.e., early preterm) also decreased from 3.66% in 2006 to 3.50% in 2010. Despite improvements in the rate of preterm births, the total number of infants born preterm remains higher than any year during 1981-2001. Substantial differences in preterm birth rates by race/ethnicity persist; additional examination of these differences can provide insight into potential areas for interventions.
An investigation of the behavior of outgassed molecules in thermal vacuums (1986)

The objective is to understand how surfaces outgas and how outgassed substances subsequently condense on other surfaces. Preliminary tests produced calculated mass losses that were found to be in reasonable agreement with mass losses determined by weighing the sample before and after testing on analytical balances. However, using test materials with various molecular properties showed characteristic variations in the ratios of calculated total mass loss to experimental loss. These variations indicate that for some molecules energetic barriers to absorption and desorption can exist between outgassed molecules and the surfaces on which they condense.
84 GBd Faster-Than-Nyquist PAM-4 Transmission Using Only Linear Equalizer at Receiver (2019)

Based on Tomlinson-Harashima precoding, we demonstrate 84 GBd PAM-4 transmission in an intensity-modulation direct-detection system with 33 GHz brick-wall bandwidth limitation. BER below 7% hard-decision FEC threshold is achieved using only linear equalizer at receiver.
Cardioprotective Effects of Nicorandil (1992)

The effects of nicorandil, a nicotinamide nitrate with K(+)-channel-opening activity, was investigated in several models of ischemia-reperfusion injury in conscious and anesthetized dogs or isolated buffer-perfused rat hearts. In several models of reversible ischemic injury (stunned myocardium) in dogs, nicorandil resulted in an enhanced recovery of regional systolic shortening during reperfusion after a single episode of coronary artery occlusion (10-15 min). These beneficial actions of nicorandil were not shared by the nitrovasodilator sodium nitroprusside but were mimicked by the selective K(+)-channel opener EMD 52692. In a model of irreversible ischemia-reperfusion injury (i.e., 2 h of coronary occlusion followed by reperfusion) in anesthetized dogs, nicorandil produced a marked reduction of myocardial infarct size. An equihypotensive dose of the calcium antagonist nifedipine had no significant effect; however, EMD 52692 produced the same reduction in infarct size as had nicorandil. In isolated, perfused rat hearts subjected to 20 min of low-flow (1.0 ml/min) global ischemia followed by 30 min of reperfusion, nicorandil (7 microM) resulted in a significant improvement in the recovery of isovolumic left ventricular minute work during reperfusion compared with untreated hearts. Finally, the results of in vitro experiments indicated that nicorandil (10(-6) to 10(-3) M) produced a concentration-dependent inhibition of superoxide anion free radical production by human and canine neutrophils. The K(+)-channel opener EMD 52692 also inhibited superoxide production in canine neutrophils. These results indicate that nicorandil is a highly efficacious myocardial protective agent in several animal models of reversible or irreversible ischemia-reperfusion injury.(ABSTRACT TRUNCATED AT 250 WORDS)
Crosslinking strategies for silk fibroin hydrogels: promising biomedical materials (2020)

Due to their strong biomimetic potential, silk fibroin (SF) hydrogels are impressive candidates for tissue engineering, due to their tunable mechanical properties, biocompatibility, low immunotoxicity, controllable biodegradability, and a remarkable capacity for biomaterial modification and the realization of a specific molecular structure. The fundamental chemical and physical structure of SF allows its structure to be altered using various crosslinking strategies. The established crosslinking methods enable the formation of three-dimensional (3D) networks under physiological conditions. There are different chemical and physical crosslinking mechanisms available for the generation of SF hydrogels (SFHs). These methods, either chemical or physical, change the structure of SF and improve its mechanical stability, although each method has its advantages and disadvantages. While chemical crosslinking agents guarantee the mechanical strength of SFH through the generation of covalent bonds, they could cause some toxicity, and their usage is not compatible with a cell-friendly technology. On the other hand, physical crosslinking approaches have been implemented in the absence of chemical solvents by the induction of β-sheet conformation in the SF structure. Unfortunately, it is not easy to control the shape and properties of SFHs when using this method. The current review discusses the different crosslinking mechanisms of SFH in detail, in order to support the development of engineered SFHs for biomedical applications.
Classification, Ontology, and Precision Medicine (2018)

Data-organizing methods have been in place for centuries, but very large data sets have come into being relatively recently. The authors describe terminologies, ontologies, and the changes needed to permit analyses of “big data” that might better serve medical decision making.
Deep learning for automated defect detection in high-reliability electronic parts (2019)

Recent advances in deep learning have shown promising results for anomaly detection that can be applied to the problem of defect detection in electronic parts. In this work, we train a deep learning model with Generative Adversarial Networks (GANs) to detect anomalies in images of X-ray CT scans. The GANs detections can then be reviewed by an analyst to confirm the presence or absence of a defect in a scan, significantly reducing the amount of time required to analyze X-Ray CT scans. We employ a trained GAN via a system referred to in the literature as an AnoGAN. We train the AnoGAN on images of X-Ray CT scans from normal, non-defective components until it is capable of generating images that are indistinguishable from genuine part scans. Once trained, we query the AnoGAN with an image of an X-ray CT scan that is known to contain a defect, such as a crack or a void. By sampling the GANs latent space, we generate an image that is as visually close to the query image as possible. Because the AnoGAN has learned a distribution over non-defective parts, it can only produce images without defects. By taking the difference between the query image and the generated image, we are able to highlight anomalous areas in the defective part. We hypothesize that this work can be used to improve speed and accuracy for quality assurance of manufactured parts by applying machine learning to non-destructive imaging.
Hydrogen-bonded chains inN-(2-nitrophenyl)phenylamine (2001)

Molecules of the title compound, C(12)H(10)N(2)O(2), are markedly non-planar. There is an intramolecular N-H...O hydrogen bond, and the molecules are linked into zigzag chains by a single C-H...O hydrogen bond. Comparisons are made with the supramolecular aggregation in isomeric amino-nitro derivatives, and in some N-methylnitroanilines.
Discrete Walsh-Hadamard transform vector quantization for motion-compensated frame difference signal coding (2003)

Theoretical performance analysis and test simulations showed that the DWHT (discrete Walsh-Hadamard transform) is as good as the DCT (discrete cosine transform) for the encoding of low-correlation MCFD (motion-compensated frame difference) signals. However, the straightforward algorithm for the DWHT makes it a better choice than the DCT. The transform vector quantization (TRVQ) technique is employed for low bit rates. It is also observed that the robustness of the VQ (vector quantization) technique for the MCFD signals is much better than that of the VQ of the still frame images.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Stochastic Gradient Methods with Layer-wise Adaptive Moments for Training of Deep Networks (2019)

We propose NovoGrad, an adaptive stochastic gradient descent method with layer-wise gradient normalization and decoupled weight decay. In our experiments on neural networks for image classification, speech recognition, machine translation, and language modeling, it performs on par or better than well tuned SGD with momentum and Adam or AdamW. Additionally, NovoGrad (1) is robust to the choice of learning rate and weight initialization, (2) works well in a large batch setting, and (3) has two times smaller memory footprint than Adam.
An Anchoring Mechanism Used to Implant a Biosensor in the Small Intestine (2013)

Capsule Endoscopy (CE) has been used in last 10 years in medical diagnosis of intestine disease such as obscure gastrointestinal bleeding(OGIB)[1]. An estimated 19 million Americans[2] suffer from these kinds of small intestine disease. The major limitation of this method is that the incomplete examination found in one research is about 20% of 2300 examinations. Also it results in a small risk of obstructive symptoms. When retention happens, high-cost, quick surgical intervention is required.