gebhart/patrepeval huggingface dataset:
Mixed-mode chromatography of nucleic acids (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMixed-mode chromatography of nucleic acidsLarry W. McLaughlinCite this: Chem. Rev. 1989, 89, 2, 309–319Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/cr00092a003https://doi.org/10.1021/cr00092a003research-articleACS PublicationsRequest reuse permissionsArticle Views864Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Figure S3 from Glucuronide-Linked Antibody–Tubulysin Conjugates Display Activity in MDR<sup>+</sup> and Heterogeneous Tumor Models (2023)

&lt;p&gt;rat tolerability&lt;/p&gt;
A novel bimodal stethoscope for gastric collection of heart sounds: preliminary results (2019)

Heart sound analysis is commonly used by physicians during auscultations to evaluate cardiac activity as a first line. These sounds originate from heartbeats and the resulting blood flow, and can provide important information about heart function and hemodynamics. The monitoring of heart sounds in patients suffering from chronic cardiac pathologies can be useful to detect or prevent cardiac events. For this purpose, a bimodal implanted gastric stethoscope was developed allowing home monitoring of electrophysiological and mechanical parameters.An in-vivo experiment in pigs was carried out to validate the feasibility of heart sound detection from an accelerometer embedded in a stethoscope prototype implanted in the submucosal layer of the gastric wall. Data recorded over several weeks validate the tolerance and the sensitivity of the device. These promising preliminary results confirm the interest of considering the stomach as a strategic implantation site for heart sound monitoring.
Autofluorescence Lifetimes Measured with Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) Are Affected by Age, but Not by Pigmentation or Gender (2020)

This study helps to understand the FLIO technology better, which will aid in conducting future clinical studies.
Assimilating Coastal Wave Observations in Regional Swell Predictions. Part I: Inverse Methods (1998)

Inverse methods are used to assimilate wave observations into numerical predictions of ocean swell (0.04-0.12 Hz surface waves) propagating over complex continental shelf bathymetry. Model predictions of swell on the shelf can be degraded by the limited accuracy and resolution of the initializing offshore (unsheltered deep water) frequency-directional spectra S o , usually derived from buoy measurements or meteorological hindcasts. The authors use a spectral refraction wave propagation model to find improved estimates of S o that are consistent with both unsheltered and sheltered (altered by coastal bathymetry) observations, and vary smoothly in direction and time.
Design of an artificial skin. IV. Use of island graft to isolate organ regeneration from scar synthesis and other processes leading to skin wound closure (1998)

Deep skin wounds in the adult mammal close spontaneously by epithelialization, wound contraction, and scar synthesis. In previous wound healing studies, it has been unsuccessfully attempted to separate from each other the natural processes that close wounds. In this study, we attempted to isolate skin regeneration from spontaneous processes of wound closure using “island” grafts. A porous analog of the extracellular matrix, composed of a graft copolymer of type I collagen and chondroitin 6-sulfate, was seeded with uncultured autologous keratinocytes and served to induce regeneration of the dermis and the epidermis. Grafts of the copolymer, measuring 1 × 2 cm, were placed in the center of 5 × 6-cm wounds in guinea pigs. By day 14, the edges of the island grafts were clearly separated from the host epidermis and dermis by a distinct bed of granulation tissue. Histologic study of island grafts on day 14 showed that the copolymer grafts had largely degraded and that a new epidermis and dermis had been synthesized in its place. The thickness of the new epidermis increased as the density of cells seeded into the graft increased. No synthesis of epidermis or dermis was observed in the granulation tissue outside the perimeter of the island grafts. We conclude that island grafting allows the study of early events in skin regeneration in isolation from epithelialization, contraction, and scar synthesis. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 39, 531–535, 1998.
Pilot Study of Correlation of Pulp Stones with Cardiovascular Disease (2005)

We propose that calcification of dental pulp may have a similar pathogenesis as calcified atheromas and could lead to use of routine dental radiographs as a rapid screening method for early identification of potential cardiovascular disease (CVD). Fifty-five dental patients ages 20 to 55 were chosen because pulp stones in pulpally noninflamed teeth were not expected in this age group. They completed a questionnaire regarding their CVD status and that of their parents and siblings. Entry criteria included at least one asymptomatic, minimally restored, noncarious molar and no history of gout, renal disease, or renal lithiasis. Patients' periapical radiographs of record were viewed to determine the presence of pulp stones. There was a significant relationship between pre-existing CVD and pulp stones (odds ratio of 4.4 with a 95% confidence interval of 1.1, 18.7), but no relationship was found for family history of CVD and pulp stones (odds ratio of 1.7 with a 95% confidence interval of 0.5, 5.5). Seventy-four percent (14/19) of patients with reported CVD had detectable pulp stones while only 39% (14/36) of patients without a history of CVD had pulp stones. This pilot study demonstrates that patients with CVD have an increased incidence of pulp stones in teeth with noninflamed pulps compared to patients with no history of CVD. No relationship was found between presence of pulp stones and family history of CVD. The findings suggest that dental radiographic determination of the presence or absence of pulp stones may have possibilities for use in CVD screening.
Blood biomarkers in Takotsubo syndrome point to an emerging role for inflammaging in disease pathophysiology (2023)

Abstract Takotsubo syndrome (TTS), an acute cardiac condition characterized by transient wall motion abnormalities mostly of the left ventricle, results in difficulties in diagnosing patients. We set out to present a detailed blood analysis of TTS patients analyzing novel markers to understand the development of TTS. Significant differences in pro-inflammatory cytokine expression patterns, sex steroid and glucocorticoid receptor (GR) expression levels were observed in the TTS patient collective. Remarkably, the measured catecholamine serum concentrations determined from TTS patient blood could be shown to be two orders of magnitude lower than the levels determined from experimentally induced TTS in laboratory animals. Consequently, exposure of endothelial cells and cardiomyocytes in vitro to such catecholamine concentrations did not damage the cellular integrity or function of neither endothelial cells forming the blood brain barrier, endothelial cells derived from myocardium nor cardiomyocytes in vitro. Computational analysis was able to link the identified blood markers, specifically, the pro-inflammatory cytokines and glucocorticoid receptor GR to microRNA (miR) relevant in the ontogeny of TTS (miR-15), and inflammation (miR-21, miR-146a), respectively. Amongst the well-described risk factors of TTS (older age, female gender), inflammaging-related pathways were identified to add to these relevant risk factors or prediagnostic markers of TTS.
The ChemPro-1000: An Evaluation Using Measurements of Sodium, Potassium, and Chloride (1987)

Journal Article The ChemPro-1000: An Evaluation Using Measurements of Sodium, Potassium, and Chloride Get access Ronald H. Ng, PhD, Ronald H. Ng, PhD Department of Laboratory Medicine, University Hospital, Boston University Medical Center, Boston, MA 02118. Search for other works by this author on: Oxford Academic PubMed Google Scholar Marcia Altaffer, MT(ASCP), Marcia Altaffer, MT(ASCP) Department of Laboratory Medicine, University Hospital, Boston University Medical Center, Boston, MA 02118. Search for other works by this author on: Oxford Academic PubMed Google Scholar Bernard Statland, MD, PhD Bernard Statland, MD, PhD Department of Laboratory Medicine, University Hospital, Boston University Medical Center, Boston, MA 02118. Search for other works by this author on: Oxford Academic PubMed Google Scholar Laboratory Medicine, Volume 18, Issue 5, 1 May 1987, Pages 306–309, https://doi.org/10.1093/labmed/18.5.306 Published: 01 May 1987
Nucleolar alterations in human tumor cells induced by vitamin C and K3 during autoschizis (2001)

peer reviewed
5924Lack of the extracellular matrix proteoglycan lumican in mice exacerbates left ventricular dilatation and contractile dysfunction upon pressure overload (2017)

than 3 hours (Fig. Several minute occlusion of the LAD induced a patchy elimination of mitochondrial membrane potentials in the cardiac myocytes (Fig. The occlusion gradually reduced the contraction/relaxation cycle in association with global constriction of the vascular network around the cardiac myocytes (Fig. Release after 5-minute occlusion induced a rapid recovery of the contraction/relaxation cycle, which was followed by cellular permeability of cardiac myocytes and re-dilated vascular networks. Subsequent release induced an accumulation of a large number of leukocytes into the cardiac tissue (Fig.
Aromastoffe der roten Passionsfrucht. Zwei neue Edulanderivate (1979)

Aroma Constituents of the Purple Passion Fruit. Two New Edulan Derivatives The isolation of (2 R *, 4 S *, 4a S *, 8a S *)‐4,4a‐epoxy‐4,4a‐dihydroedulan ( 1 ), and (2 R *, 3 S *, 8a S *)‐3‐hydroxyedulan ( 2 ), two new constituents of the purple passion‐fruit ( Passiflora edulis S IMS ), is reported. Racemic epoxide 1 was synthesized by oxidation of edulan 6 with peracidic acid, and racemate of alcohol 2 was obtained by reduction of ketone 7 , one of the chromic acid oxidation‐products of edulan 6 .
Immunoadsorption therapy in autoimmune encephalitides (2016)

This study provides Class IV evidence that immunoadsorption combined with immunosuppression therapy is effective in patients with autoimmune encephalitis with surface antibodies.
Interface modification of sputtered NiOx as the hole-transporting layer for efficient inverted planar perovskite solar cells (2019)

An appropriately combined triple interface modification, <italic>i.e.</italic>, post-annealing, O<sub>2</sub>-plasma, and KCl treatments, is employed to ameliorate the optoelectronic properties of sputtered NiO<sub>x</sub> films and achieve better device performance.
Initial Results of IEC 62804 Draft Round Robin Testing (2013)

This presentation discusses the Initial round robin results of the IEC 62804 system voltage durability qualification test for crystalline silicon modules.
Automatic assignment of metal-containing peptides in proteomic LC-MS and MS/MS data sets (2017)

Transition metal-containing proteins and enzymes are critical for the maintenance of cellular function and metal-based (metallo)drugs are commonly used for the treatment of many diseases, such as cancer. Detection and characterisation of metallodrug targets is crucial for improving drug-design and therapeutic efficacy. Due to the unique isotopic ratios of many metal species, and the complexity of proteomic samples, standard MS data analysis of these species is unsuitable for accurate assignment. Herein a new method for differentiating metal-containing species within complex LCMS data is presented based upon the Smart Numerical Annotation Procedure (SNAP). SNAP-LC accounts for the change in isotopic envelopes for analytes containing non-standard species, such as metals, and will accurately identify, record, and display the particular spectra within extended LCMS runs that contain target species, and produce accurate lists of matched peaks, greatly assisting the identification and assignment of modified species and tailored to the metals of interest. Analysis of metallated species obtained from tryptic digests of common blood proteins after reactions with three candidate metallodrugs is presented as proof-of-concept examples and demonstrates the effectiveness of SNAP-LC for the fast and accurate elucidation of metallodrug targets.
Atmospheric pollutant emission factors from open burning of agricultural and forest biomass by wind tunnel simulations. Volume 1. Final report (1996)

Atmospheric pollutant emission factors were determined by wind tunnel simulations of spreading and pile fires for 8 different types of fuel including barley, rice and wheat straw, corn stover, almond and walnut tree prunings, and Douglas fir and Ponderosa pine slash. Cereal straws and stover were burned in fires spreading against an impressed wind, pile burns in wood fuels were naturally ventilaled through the side doors. Emission factors were determined for each fuel for CO, NO, NOx, SO2, total hydrocarbons, methane, nonmethane hydrocarbons, total sulfur, CO2, particulate matter, volatile organic matter (VOC), and polycyclic aromatic hydrocarbons (PAH). Elemental compositions of particulate matter were determined by size category. Bulk aerosol absorption coefficients were determined from light transmission measurements through filter samples. Emission rates were correlated against burning conditions and fuel compositions. Factor affecting the burning rates and emission factors included inlet air temperature, loading rate, and wind speed.
Open Patellar Tendon Tenotomy, Debridement, and Repair Technique Augmented With Platelet‐Rich Plasma for Recalcitrant Patellar Tendinopathy (2017)

Patellar tendinopathy is a disabling condition that frequently affects the athletic population, especially athletes undergoing repetitive impact forces as a result of jumping and landing activities. Most cases are initially treated conservatively, but if symptoms persist, surgical treatment is warranted. Options for surgical treatment include both arthroscopic and open techniques. The purpose of this Technical Note is to detail our open patellar tendon tenotomy, debridement, and repair technique augmented with platelet-rich plasma.
Linkage Disequilibrium (2014)

Abstract The nonrandom association between alleles at different loci is termed linkage disequilibrium. This note discusses the origin of this concept, its theoretical genetic basis, its estimation and tests of significance, and applications. Linkage disequilibrium studies are critical in human disease gene mapping and is now a major area of research with the availability of variation of the human genome sequence.
Sarcopenia: Effects on Body Composition and Function (2003)

Sarcopenia is the loss of muscle mass that happens to everyone with age. However, the rate of sarcopenia and the severity of its sequelae vary greatly according to health status, physical activity, and possibly diet. In this review, I discuss the potential mechanisms of sarcopenia and some ideas about prevention and treatment.
Determination of Free-Radical Propagation Rate Coefficients of Butyl, 2-Ethylhexyl, and Dodecyl Acrylates by Pulsed-Laser Polymerization (1996)

Analysis of the molecular weight distributions (MWDs) of polymer produced by pulsed-laser polymerization (PLP) is an effective method for the determination of free-radical propagation rate coefficients (kp). The PLP technique has been successfully applied to many slowly propagating monomers, but kp determination by PLP for faster propagating systems such as the acrylates is more difficult. Experimental conditions for the polymerization must be selected so that laser pulses are the dominant chain-starting and chain-stopping events. Interference from excessive chain-transfer reactions, or from termination reactions which are either too fast or too slow, results in MWDs which are not suitable for kp determination. Guidelines for design of successful experiments are outlined using an extensive n-butyl acrylate data set, from which kp has been determined over the temperature range 5−30 °C; limited data for n-dodecyl acrylate and 2-ethylhexyl acrylate are also presented.
Stakeholder-based decision support model for selection of alternative water sources - A path towards sustainable industrial future in Vietnam (2022)

The combined effect of climate change, rapid industrialisation and traditional water use has created freshwater stress situations in industrial delta regions. Alternative Water Sources (AWSs) offer opportunities to mitigate the freshwater stress issue and, thus, contribute to a sustainable industrial future. This study developed a Decision Support Model (DSM) to assist the decision-makers in selecting the most feasible AWS. In the study location, Tan Thuan Export and Processing Zone (TTZ) of Ho Chi Minh City, rainwater, industrial effluent and brackish water were selected as AWS options and evaluated for technical, environmental, economic, social and institutional criteria. The stakeholder organisations representing government organisations, industrial-zone management organisations and enterprises were selected as decision-makers based on their willingness to explore AWSs. Four DSM scenarios were derived from the varying decision-making power of the selected stakeholder organisations. The results obtained from applying DSM in TTZ showed rainwater as the most feasible AWS for all the scenarios, while the rank of other AWSs fluctuated for different scenarios. To implement the result of DSM in practice, the government should not only focus on formulating clear technological guidelines on AWS quality but also on providing subsidies and creating an environment of social acceptance of AWSs. The DSM allows the decision-makers to determine the most capable AWS in mitigating freshwater stress issues and the changes required to shift towards these AWSs.
Bis(trimethylsilyl)phosphinodithioformates, the phosphorus analogues of dithiocarbamates; X-ray structure of [Zr(cp)2(Cl)(η2-S2CPR2)] and its thermolysis product [{Zr(cp)2(µ-S)}2](cp =η-C5H5, R = SiMe3) (1987)

Carbon disulphide inserts under ambient conditions into the Zr–P bond of [Zr(cp)2(PR2)X][cp =η-C5H5, R = SiMe3] to yield [Zr(cp)2(η2-S2CPR2)X][X = Cl (1a) or Me (1b)](having the novel phosphinodithioformato ligand, a phosphorus analogue of the dithiocarbamate), which upon heating affords [{Zr(cp)2(µ-S)}2](3){also obtained from S8 and [Zr(cp)2(PR2)X](X = Me or PR2)}; the [graphic omitted] and [graphic omitted] rings in (1a) and (3) are planar and the P environment in (1a) is pyramidal, with 〈Zr–S〉 2.686(8)(1a) and 2.483(3)Å(3) and SZrS′ 63.4(2)(1a) and 89.5(2)°(3).
RETICULAR MACULAR DISEASE IS ASSOCIATED WITH MULTILOBULAR GEOGRAPHIC ATROPHY IN AGE-RELATED MACULAR DEGENERATION (2013)

Autofluorescence and infrared imaging demonstrates that RMD is nearly always present with multilobular GA in age-related macular degeneration. Furthermore, GA lobules frequently develop in areas of RMD, suggesting progression of a single underlying disease process.
PRE COLONOSCOPY MEDICAL EVALUATION – A MODEL PROGRAM TO FACILITATE SCREENING OR SURVEILLANCE COLONOSCOPY (2004)

Purpose: Screening colonoscopy is increasingly utilized for prevention and early detection of colorectal cancer (CRC). Current practice requires a pre procedure medical evaluation because of the risks involved. The evaluation is usually done by the referring physician (MD) or the gastroenterologist who performs the procedure. This can be time consuming and may deter patients from self referral for the procedure. As part of our Cancer Prevention and Wellness Program, we tested a model in which a nurse practitioner (NP) performs this pre procedure evaluation. Our purpose was to determine if this NP model program can safely and efficiently evaluate patients for screening colonoscopy. Methods: Patients who presented to our program seeking screening or surveillance for CRC were evaluated by NP's to determine eligibility for screening or surveillance colonoscopy (based on institutional approved guidelines), and medical appropriateness and safety. Patients had a history and physical exam performed by the NP's, lab tests, and were given instructions on bowel preparation for colonoscopy. Those with significant GI symptoms were referred to a gastroenterologist. Those with other active medical problems were referred to an internist. A retrospective chart review was performed. Results: Over a one year period 215 patients presented to the program seeking screening or surveillance colonoscopy. 145 (67.5%) were cleared for colonoscopy by the NP's and did not require evaluation by an MD prior to procedure. 70 patients required an MD evaluation prior to colonoscopy (58 patients by a gastroenterologist, 12 by an internist). 60 of these patients followed up with their referral appointments. In total, 184 (85.6%) patients presented for the colonoscopy procedure. Colonoscopy reached the cecum in 181 (98%) patients. There were no medical complications related to the colonoscopy procedures, nor perforations or bleeding. Conclusions: Pre colonoscopy medical evaluation can be safely and efficiently performed by NP's, eliminating the need for evaluation by the gastroenterologist or other MD. This may facilitate access, simplify the process, and increase utilization of screening colonosocpy by the general population.
Standard transthoracic echocardiography and transesophageal echocardiography views of mitral pathology that every surgeon should know. (2015)

The mitral valve is the most commonly diseased heart valve and the prevalence of mitral valve disease increases proportionally with age. Echocardiography is the primary diagnostic imaging modality used in the assessment of patients with mitral valve disease. It is a noninvasive method which provides accurate anatomic and functional information regarding the mitral valve and can identify the mechanism of mitral valve pathology. This is especially useful as it may guide surgical repair. This is increasingly relevant given the growing trend of patients undergoing mitral valve repair. Collaboration between cardiac surgeons and echocardiographers is critical in the evaluation of mitral valve disease and for identification of complex valvular lesions that require advanced surgical skill to repair. This article will provide an overview of transthoracic and transesophageal assessment of common mitral valve pathology that aims to aid surgical decision making.