gebhart/patrepeval huggingface dataset:
Rational design of class I MHC ligands (1995)

From the knowledge of the three‐dimensional structure of a class I MHC protein, several non natural peptides were designed in order to either optimize the interactions of one secondary anchor amino acid with its HLA binding pocket or to substitute the non interacting part with spacer residues. All peptides were synthesized and tested for binding to the class I MHC protein in an in vitro reconstitution assay. As predicted, the non natural peptides present an enhanced binding to the HLA‐B27 molecule with respect to their natural parent peptides. This study constitutes the first step towards the rational design of non peptidic MHC ligands that should be very promising tools for the selective immunotherapy of autoimmune diseases.
Progress in supervised neural networks (1993)

Theoretical results concerning the capabilities and limitations of various neural network models are summarized, and some of their extensions are discussed. The network models considered are divided into two basic categories: static networks and dynamic networks. Unlike static networks, dynamic networks have memory. They fall into three groups: networks with feedforward dynamics, networks with output feedback, and networks with state feedback, which are emphasized in this work. Most of the networks discussed are trained using supervised learning.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Adopting the Principles of Collagen Biomineralization for Intrafibrillar Infiltration of Yttria‐Stabilized Zirconia into Three‐Dimensional Collagen Scaffolds (2013)

In this paper, we report a process for generating collagen-yttria-stabilized amorphous zirconia hybrid scaffolds by introducing acetylacetone-inhibited zirconia precursor nanodroplets into a poly(allylamine)-coated collagen matrix. This polyelectrolyte coating triggers intrafibrillar condensation of the precursors into amorphous zirconia, which is subsequently transformed into tetragonal yttria-stabilized zirconia after calcination. Our findings represent a new paradigm in the synthesis of non-naturally occurring collagen-based hybrid scaffolds under alcoholic mineralizing conditions.
α-Alkylation of Ketones by Addition of Zinc Enamides to Unactivated Olefins (2004)

A zinc enamide generated from the corresponding N-aryl imine undergoes addition to an unactivated olefin, such as ethylene, 1-octene, and isobutylene, to generate an alpha-alkylated gamma-zincioimine intermediate in good to excellent yield. Terminal and gem-disubstituted olefins react with >99% regioselectivity, allowing the C-C bond formation to take place at the more hindered carbon of the double bond. The organozinc intermediate undergoes further C-C bond formation with a carbon electrophile to give, upon hydrolysis of the imine, an alpha-alkylated ketone bearing a variety of functionalized primary, secondary, and tertiary alkyl groups.
Cytokine balance is restored as patient‐reported outcomes improve in patients recovering from chronic hepatitis C (2019)

These data indicate relationships between PROs and serum biomarkers pre- and post-SVR in CHC. These concomitant changes may have important clinical relevance.
Ethyl 1'-[1-(4-methoxyphenyl)-3-phenoxy-4-phenylazetidin-1-yl]-1,3-dioxo-2′,3′,5′,6′,7′,7a′-hexahydroindan-2-spiro-3′-1′H-pyrrolizine-2′-carboxylate (2008)

In the title compound, C(34)H(32)N(2)O(7), the methyl group and methylene H atoms of the ethoxycarbonyl substituent are disordered over two positions with site occupancy factors for the major and minor conformers of 0.594 (8) and 0.406 (8), respectively. The unsubstituted ring of the pyrrolizine ring system exhibits a twist conformation, the other an envelope conformation. In the crystal structure, mol-ecules are linked through C-H⋯O hydrogen bonds; intramolecular C-H⋯O interactions are also observed.
Optical Fiber Humidity Sensor Based on Lossy Mode Resonances Supported by TiO2/PSS Coatings (2011)

In this work it is presented the fabrication of titanium dioxide (TiO2) and poly(sodium 4-styrenesulfonate) (PSS) resonance supporting coatings onto optical fibers and their utilization as transducers for relative humidity (RH) sensing. The fabrication of the TiO2/PSS coatings has been performed by means of the layer-by-layer (LbL) electrostatic self-assembly technique using the core of optical fibers as the substrate, which permits to generate several resonances in the visible and infrared spectral region. These resonances vary as a function of the refractive index of the medium in contact with the TiO2/PSS layer. Moreover, the water vapor content of the surrounding medium produces a shift of the resonances that enables the monitorization of the RH. This characteristic permits to obtain an optical fiber sensing device based on wavelength detection with fast response times and good repeatability as well as the possibility to perform self-referenced measurements by means of monitoring two resonances.
Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules. (1982)

A specific carboxypeptidase that converts enkephalin precursors into enkephalin in adrenal chromaffin granules has been purified and characterized. In the adrenal this enzyme, designated enkephalin convertase, is uniquely localized to the chromaffin granules, which contain enkephalin and precursor peptides. Enkephalin convertase is markedly stimulated by CoCl2 and inhibited by EDTA or 1,10-phenanthroline, unlike the lysosomal carboxypeptidase. The purified enzyme has a high affinity for the hexapeptides [Met5]- and [Leu5]enkephalin-Arg6 (51 and 83 microM, respectively) and a somewhat lower affinity for the hexapeptides [Met5]- and [Leu5]enkephalin-Lys6 (195 and 174 microM). Brain enkephalin convertase shows 10-fold regional variations, unlike other carboxypeptidases, which are uniformly distributed. Enkephalin convertase appears to be associated selectively and physiologically with biosynthesis of the enkephalins.
THE DEGRADATION OF COLCHICINE TO OCTA-HYDRODEMETHOXYDESOXYDESACETAMIDO-COLCHICINE (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE DEGRADATION OF COLCHICINE TO OCTA-HYDRODEMETHOXYDESOXYDESACETAMIDO-COLCHICINEHenry Rapoport and Arthur R. WilliamsCite this: J. Am. Chem. Soc. 1951, 73, 4, 1896–1897Publication Date (Print):April 1, 1951Publication History Published online1 May 2002Published inissue 1 April 1951https://pubs.acs.org/doi/10.1021/ja01148a561https://doi.org/10.1021/ja01148a561research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dissolution fundamentals of 193-nm methacrylate based photoresists (2006)

The dissolution of partially deprotected chemically amplified photoresists is the final step in printing lithographic features. Since this process step can be tuned independently from the design of the photoresist chemistry, measurements of the dissolution behavior may provide needed insights towards improving line-edge roughness. We have studied the dissolution behavior of a model 193-nm photoresist, poly (methyladamantyl methacrylate), as a function of deprotection extent and developer strength. The kinetics of the dissolution process is followed using the quartz crystal microbalance technique. These photoresist films exhibit strong swelling without dissolution over a significant range of deprotection levels. At larger extents of deprotection, we observe a combination of swelling with dissolution. Additionally, we find that the degree of film swelling decreases with tetramethylammonium hydroxide developer concentration. These studies provide the insight needed to better understand the fundamentals of the dissolution of the photoresist - a key step in lithographic process.
A New Approach for Reduced Order Modeling of Mechanical Systems Using Vibration Measurements (2003)

This study investigates the possibilities of obtaining reduced order mass-damping-stiffness models of mechanical systems using state space realizations identified via dynamic tests. It is shown that even when the system is insufficiently instrumented with sensors and actuators, it is still possible to create physically meaningful reduced order mass-damping-stiffness models that incorporate measured and unmeasured degrees of freedom. It is further discussed that certain assumptions, such as having a diagonal mass matrix or having classical damping in the system, allow one to develop alternative reduced order representations with different physical interpretations. The theoretical presentation is supplemented by a numerical example that illustrates the applications of the formulations developed herein.
Synthetic recognition systems : self-assembly and metal chelation (1994)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
Sonofragmentation of Organic Molecular Crystals vs Strength of Materials (2021)

Mechanochemistry, the interface between the chemical and the mechanical worlds, includes the relationship between the chemical and mechanical properties of solids. In this work, fragmentation of organic molecular crystals during ultrasonic irradiation of slurries has been quantitatively investigated. This has particular relevance to nucleation processes during sonocrystallization, which is increasingly used in the processing and formulation of numerous pharmaceutical agents (PAs). We have discovered that the rates of sonofragmentation are very strongly correlated with the strength of the materials (as measured by Vickers hardness and Young's modulus). This is a mechanochemical extension of the Bell-Evans-Polanyi Principle or Hammond's Postulate: the kinetics (i.e., rates) of solid fracture correlate with thermodynamic properties of solids (e.g., Young's modulus). The mechanism of the particle breakage is consistent with a direct interaction between the shockwaves or localized microjets created by the ultrasound (through acoustic cavitation) and the solid particles in the slurry. Comparisons of the sonofragmentation patterns of ionic and molecular crystals showed that ionic crystals are more sensitive to sonofragmentation than molecular crystals for a given Young's modulus. The rates of sonofragmentation are proposed to correlate with the types and densities of imperfections in the crystals.
The gonadotropin‐releasing hormone family of neuropeptides in the brain of human, bovine and rat: identification of a third isoform (1999)

The mammalian gonadotropin-releasing hormone (GnRH-I), which regulates reproduction, was the first isoform of GnRH that was identified in mammals. Recently, we and others have demonstrated the existence of a second isoform of GnRH in the brain of mammals. The presence of a third isoform of GnRH, GnRH-III, in the brain of mammals is reported herein. GnRH-III, extracted from the brain of bovine and human, was purified by high performance liquid chromatography, using two distinct elution programs. In both, GnRH-III was eluted at the same positions as synthetic salmon GnRH, as demonstrated by radioimmunoassay. The luteinizing hormone-releasing activity of purified GnRH-III, using dispersed rat pituitary cells, was found to be similar to that of synthetic salmon GnRH. The total amount of GnRH-III, determined by radioimmunoassay, in the hypothalamus and midbrain of humans and calves is similar to that of GnRH-I. Immunohistochemical studies demonstrated GnRH-III-containing neurons in the hypothalamus and midbrain of human and GnRH-III fibers in the median eminence of rats. The distribution of GnRH-III in the brain suggests that in addition to a putative function as a neurohormone at the hypothalamic-pituitary axis, GnRH-III may have other functions. Our present results suggest that multiple isoforms of GnRH are present in the brain of mammals, and further studies are required in order to elucidate their biological functions.
Compact transmission-line equivalent circuit model for silicon solar cell simulation (2019)

We demonstrate a compact equivalent circuit model for transmission-line representation of monocrystalline silicon solar cell. The model is suitable for solar cell characterization in terms of impedance/admittance spectroscopy. Number of coordinate partition elements necessary to adequately represent the device characteristics is reasonably comparable with the number of solar cell structure epi-layers. This makes the model convenient for transient effect simulations in external electrical circuits where fully distributed transmission-line model is too complex for direct time-domain calculations.
Semiconductor Quantum Bits (2008)

Preface Spin and Charge Qubits 1. Coded Qubit Based on Electron Spin M. Korkusinski and P. Hawrylak 2. Quantum Optical Studies of Single Coupled Quantum Dot Pairs G. J. Beirne, M. Jetter, and P. Michler 3. Nuclear Spin Bi-stability in Semiconductor Quantum Dots A. I. Tartakovskii, M. S. Skolnick, A. Russell, and V. I. Fal'ko 4. Nonequilibrium Optical Spin Cooling in Charged Quantum Dots I. A. Akimov, D. H. Feng, and F. Henneberger Qubit Control, Readout, and Transfer 5. Electron Spin Quantum Bits in Quantum Dots: Initialization, Decoherence, and Control A. Greilich, D. R. Yakovlev, M. Bayer, A. Shabaev, and A. L. Efros 6. Optical Control of Quantum-Dot Spin States M. Atat ure, J. Dreiser, A. Badolato, and A. Imamo_glu 7. Optical Read-out of Single Carrier Spin in Semiconductor Quantum Dots F. Troiani, I. Wilson-Rae, and C. Tejedor 8. Quantum State Transfer from a Photon to an Electron Spin in Quantum Dots and Quantum Dynamics of Electron-Nuclei Coupled System T. Takagahara and O. ^ Cakir Qubit Decoherence 9. Spin Quantum-bits and Decoherence in InAs/GaAs Quantum Dots B. Urbaszek, T. Amand, O. Krebs, P. Renucci, and X. Marie 10. Electron and Hole Spin Dynamics and Decoherence in Quantum Dots D. Klauser, D. V. Bulaev, W. A. Coish, and D. Loss 11. Microscopic Theory of Energy Dissipation and Decoherence in Semiconductor Nanodevices F. Rossi 12. Transient Four-wave Mixing of Excitons in Quantum Dots from Ensembles and Individuals P. Borri and W. Langbein Flying Qubits 13. Light-matter Interaction in Single Quantum Dot - Micropillar Cavity Systems S. Reitzenstein, J.-P. Reithmaier, and A. Forchel 14. Entangled Photons via Biexciton-Resonant Hyperparemetric Scattering K. Edamatsu 15. Entangled Photon Pair Emission and Interference from Single Quantum Dots R. M. Stevenson, R. J. Young, and A. J. Shields Qubit Applications 16. Telecom-wavelength Single-photon Sources Based on Single Quantum Dots M. B. Ward, A. J. Shields, B. Alloing, C. Zinoni, C. Monat, and A. Fiore 17. Quantum Information Processing with Quantum Dots in Photonic Crystals J. Vu_ckovi_c, D. Englund, A. Faraon, I. Fushman, and E. Waks 18. High-Speed Quantum Computers with Semiconductor Spins T. D. Ladd, K. Sanaka, K. M. C. Fu, S. Koseki, D. Press, S. M. Clark, K. De Greve, and Y. Yamamoto 19. Quantum Dots: Single-Photon Sources for Quantum Information M. Scholz, T. Aichele, and O. Benson Author Index Subject Index
Unexpected Self‐Sorting Self‐Assembly Formation of a [4:4] Sulfate:Ligand Cage from a Preorganized Tripodal Urea Ligand (2015)

The design and synthesis of tripodal ligands 1-3 based upon the N-methyl-1,3,5-benzenetricarboxamide platform appended with three aryl urea arms is reported. This ligand platform gives rise to highly preorganized structures and is ideally suited for binding SO4 (2-) and H2 PO4 (-) ions through multiple hydrogen-bonding interactions. The solid-state crystal structures of 1-3 with SO4 (2-) show the encapsulation of a single anion within a cage structure, whereas the crystal structure of 1 with H2 PO4 (-) showed that two anions are encapsulated. We further demonstrate that ligand 4, based on the same platform but consisting of two bis-urea moieties and a single ammonium moiety, also recognizes SO4 (2-) to form a self-assembled capsule with [4:4] SO4 (2-) :4 stoichiometry in which the anions are clustered within a cavity formed by the four ligands. This is the first example of a self-sorting self-assembled capsule where four tetrahedrally arranged SO4 (2-) ions are embedded within a hydrophobic cavity.
Inline-fähige Prüftechnik von Lithium-Ionen-Batterien/Inline test systems for the electrode production of lithium-ion batteries (2021)

Bei der Fertigung von Batteriezellen in millionenfacher Anzahl ist eine gleichbleibend hohe Qualität von großer Bedeutung und die Sicherstellung eine ebensolche Herausforderung. Daneben sind Aspekte wie Kostenreduktion und Ressourcenschonung entscheidend für die zukünftige Verbreitung von Lithium-Ionen-Batterien für die Elektromobilität aber auch für den vermehrten Anwendungsfall der stationären Energiespeicherung. Produktionsintegrierte Prüfsysteme gekoppelt mit KI-basierten Datenkonzepten sind ein zentrales Element für eine effektive Qualitätssicherung und damit eine erhöhte Gesamtwirtschaftlichkeit in einer digitalen Batterieproduktion. &amp;nbsp; In battery cell production, it is of great importance and an equally great challenge to produce millions of units of consistently high quality. In addition, aspects such as cost reduction and resource conservation are crucial for the future spread of lithium-ion batteries for electromobility but also for the increased use in stationary energy storage. Production-integrated testing systems coupled with AI-based data concepts are a central element for effective quality assurance and thus increased overall cost-effectiveness in digital battery production.
Supplementary document for Second harmonic generation of spatiotemporal optical vortices (STOVs) and conservation of orbital angular momentum - 5162141.pdf (2021)

simulations, detailed experimental setup, simple model for STOV splitting
A fully-integrated detector for NMR microscopy in 0.13&#x03BC;m CMOS (2013)

In this paper, we present a fully integrated receiver for NMR microscopy applications realized in a 0.13 μm CMOS technology. The chip co-integrates a planar detection coil together with a complete low-IF downconversion receiver consisting of a low noise amplifier, a quadrature downconversion mixer, a baseband amplifier stage and line drivers. The chip operates from a single 1.5V supply and consumes about 12mA of current. The active chip area is about 350×450 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The detector's measured input referred voltage noise density at the operating frequency of 300 MHz is 260 pV/√Hz resulting in a measured spin sensitivity of 2×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">13</sup> spins/√Hz. Preliminary imaging experiments demonstrate the chip's capability of recording micron resolution MR images in imaging times which significantly advance the state-of-the-art.
The Throughput of Packet Broadcasting Channels (2009)

Packet broadcasting is a form of data communications architecture which can combine the features of packet switching with those of broadcast channels for data communication networks. Much of the basic theory of packet broadcasting has been presented as a byproduct in a sequence of papers with a distinctly practical emphasis. In this paper we provide a unified presentation of packet broadcasting theory. In Section II we introduce the theory of packet broadcasting data networks. In Section III we provide some theoretical results dealing with the performance of a packet broadcasting network when the users of the network have a variety of data rates. In Section IV we deal with packet broadcasting networks distributed in space, and in Section V we derive some properties of power-limited packet broadcasting channels, showing that the throughput of such channels can approach that of equivalent point-to-point channels.
Numerical simulation of metal interconnects of power semiconductor devices (2010)

This paper presents a methodology and a software tool – R3D – for extraction, simulations, analysis, and optimization of metal interconnects of power semiconductor devices. This tool allows an automated calculation of large area device Rdson value, to analyze current density and potential distributions, to design sense device, and to optimize a layout to achieve a balanced and optimal design. R3D helps to reduce the probability of a layout error, and drastically speeds up and improves the quality of layout design.
Über die Reaktion von Ketenen mit o‐Chinonen, IV. Cyclische Addukte aus o‐Chinonen und Dimethylketeniminen (1966)

Abstract N ‐substituierte aliphatische Ketenimine bilden, analog Diphenylketeniminen, mit o ‐Chinonen cyclische 1:1‐Addukte (Tab. 1), die Lactonanile sind.
Synchronized-by-Default Concurrency for Shared-Memory Systems (2017)

We explore a programming approach for concurrency that synchronizes all accesses to shared memory by default. Synchronization takes place by ensuring that all program code runs inside atomic sections even if the program code has external side effects. Threads are mapped to atomic sections that a programmer must explicitly split to increase concurrency.
Two-stage optical limiting fiber amplifier using a synchronized etalon filter (1998)

We demonstrate a two-stage optical limiting erbium-doped fiber amplifier (OLA) using an interstage synchronized etalon filter and an isolator. The proposed OLA shows higher gain, lower noise figure, and wider dynamic range (>30 dB) than conventional two-stage erbium-doped fiber amplifiers (EDFAs) with an interstage isolator. In addition, this OLA is well suited for the use in wavelength-division multiplexed (WDM) networks since the synchronized etalon filter has multiple passbands at the standardized WDM wavelengths.
Numerical and Experimental Investigation of Field Distribution in Waveguide Filled with Anisotropic Single Negative Metamaterial (2005)

A field distribution in a rectangular waveguide filled with anisotropic single-negative (SNG) metamaterial is analyzed theoretically, numerically and experimentally. A highly simplified scenario with ideal lossless, continuous (either mu-negative (MNG) or epsilon-negative (ENG)) filling material is used in theoretical analysis. The results show that distributions of magnitudes of E and H fields are similar to the associated distributions in ordinary waveguide (filled with double-positive (DPS) material) that operates above cut-off frequency. However, the crucial difference, responsible for recently demonstrated peculiar phenomenon of backward wave propagation below cut-off is a pattern of field lines of either H field (a case with MNG filling) or E field (a case with ENG filling). Numerical approach that dealt with realistic structures (double-ring-resonator-based MNG metamaterial and thin-wire-based ENG metamaterial) confirmed existence of backward-wave propagation. Two experimental waveguides filled with double-ring resonators (an MNG filling) and thin wires (an ENG filling) were successfully designed, manufactured and tested in 8 GHz band. The backward-wave propagation was verified by measurement of a phase distribution along a waveguide with the help of a small E field probe.