gebhart/patrepeval huggingface dataset:
Carbohydrate oxidation disorders of skeletal muscle (2002)

Although major progress has been made in an understanding of the molecular genetic bases of carbohydrate oxidation defects, the pathophysiology of exercise intolerance and muscle weakness remains to be further clarified. Gene therapy and dietary therapeutic regimes appear promising, but need to be actively investigated in the future.
Einfluß von Endothelin-Rezeptor-Antagonisten auf die Ausbildung einer Nephropathie bei Ratten mit Streptozotozin-induziertem Diabetes mellitus (2007)

Zur Beantwortung der Frage, ob die Blockade von Endothelinrezeptoren in einem Diabetes-Modell einen Einfluß auf die Ausprägung von Schädigungszeichen an der Niere hat, wurde eine tierexperimentelle Studie durchgeführt. Dazu wurde bei Wistar-Ratten durch Injektion von Streptozotozin ein Diabetes mellitus induziert. Ein Teil der Tiere wurde mit einem selektiven ETA-Rezeptorblocker (LU 135252), ein weiterer Teil mit einem kombinierten ETA/ETB-Rezeptorblocker (LU 224332) behandelt. Als Kontrolltiere dienten nicht behandelte Diabetische Tiere, sowie behandelte und nicht-behandelte Nicht-Diabetische Tiere. Über einen Zeitraum von 36 Wochen wurden diverse klinische und laborchemische Parameter wiederholt erfasst. Im Anschluß wurden die Nieren aller Tiere lichtmikroskopisch unter Einsatz verschiedener Färbungen und spezieller Verfahren der EDV untersucht. Als Zielparameter für die Nephropathie wurden Proteinurie/Albuminurie, Interstitielle Fibrose und Glomerulosklerose gewählt. Die Untersuchungen des Effektes von Endothelinrezeptoren auf die Entwicklung renaler Schädigungen ergaben eine signifikante Abnahme der Schädigungszeichen unter dem Einfluß des selektiven ETA-Rezeptor-Blockers. Ein zusätzlicher Effekt durch die additive Blockade des ETB-Rezeptors konnte dabei nicht festgestellt werden. Bereits bei anderen Untersuchungen im Zusammenhang mit Nephropathien unterschiedlicher Genese wurde von der Bedeutung des ETA- Rezeptors und des Endothelin-1 berichtet. In der vorliegenden Studie wurde der renoprotektive Effekt selektiver und kombinierter ET-Rezeptorantagonisten, die ab dem Zeitpunkt der Diabetes-Induktion verabreicht wurden, verglichen. Weitere Untersuchungen zu Langzeiteffekten (Verträglichkeit, Wirkungsverlust, Teratogenität), Wechselwirkungen im Zusammenhang mit Ko-Medikamenten (z.B. ACE-Hemmer bzw. AT-II-Rezeptorblocker) und die Anwendbarkeit der bei den in- vitro- bzw. tierexperimentellen Untersuchungen erhobenen Daten auf den Menschen, insbesondere auf die zum Teil hoch komorbiditätsbelasteten Patienten, die von einem entsprechenden therapeutischen Werkzeug profitieren könnten, eröffnen ein weites Feld für zukünftige Untersuchungen.
A model-based simulator for testing rule-based decision support systems for mechanical ventilation of ARDS patients. (1994)

A model-based simulator was developed for testing rule-based decision support systems that manages ventilator therapy of patients with the Adult Respiratory Distress Syndrome (ARDS). The simulator is based on a multi-compartment model of the human body and mathematical models of the gas exchange abnormalities associated with ARDS. Initial testing of this system indicates that model-based simulators are a viable tool for testing rule-based expert systems used in health-care.
Flare‐related Magnetic Anomaly with a Sign Reversal (2003)

In this paper we report a significant magnetic anomaly, specifically an apparent sign reversal of magnetic polarities in small areas of Michelson Doppler Imager (MDI) magnetograms during the impulsive phase of an X5.6 flare on 2001 April 6. Three flare kernels were observed to emit ≥50 keV hard X-rays, which are located in strong magnetic fields of order ±1000-1500 G. We find that the apparent sign reversal began and persisted for a few minutes in all three kernels, in precise temporal and spatial correspondence with the hard X-ray sources. We search for a combination of instrumental and flare-induced line profile effects that can account for this behavior. Our studies provide a viable scenario that the observed transient sign reversal is likely to be produced by distorted measurements when the Ni I 6768 Å line comes into emission or strong central reversal as a result of nonthermal beam impact on the atmosphere in regions of strong magnetic fields.
Unexplained infertility (1993)

Journal Article Unexplained infertility Get access P.G. Crosignani, P.G. Crosignani 1Department of Obstetrics and Gynaecology, University of MilanHamilton, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Collins, J. Collins 2Department of Obstetrics and Gynaecology, McMaster UniversityHamilton, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar I.D. Cooke, I.D. Cooke 3Department of Obstetrics and Gynaecology, University of SheffieldSheffield, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Diczfalusy, E. Diczfalusy 4Department of Reproductive Endocrinology, Karolinska InstituteStockholm, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar B. Rubin, B. Rubin 5Via Lipari 4, Milan, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar The recommendations of the ESHRE workshop on 'Unexplained Infertility', held in Anacapri, August 28–29, 1992, are given below. P.G.Crosignani, J.Collins, I.D.Cooke, E.Diczfalusy and B.Rubin prepared the guidelines on behalf of the group. The recommendations of the ESHRE workshop on 'Unexplained Infertility', held in Anacapri, August 28–29, 1992, are given below. P.G.Crosignani, J.Collins, I.D.Cooke, E.Diczfalusy and B.Rubin prepared the guidelines on behalf of the group. Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Reproduction, Volume 8, Issue 6, 1 June 1993, Pages 977–980, https://doi.org/10.1093/oxfordjournals.humrep.a138177 Published: 01 June 1993 Article history Received: 10 February 1993 Accepted: 10 February 1993 Published: 01 June 1993
Simple beam control of end-fire antenna using FSS for MM-wave applications (2017)

In this paper, a simple beam tilting of an end-fire antenna by integrating a Frequency Selective Surface (FSS) at 30 GHz is proposed. A modified uniplanar compact FSS (MUC-FSS) is designed to obtain a bandpass in the desired direction and a bandstop in the other direction. Simulation results of integrating the proposed FSS (1 layer of 3×5 unit cells) under the directors of the antenna show that the main beam radiation tilts in the end-fire direction by +27° and -17° when the FSS structures are rotated by 90° at 30 GHz. A bandwidth from 28GHz to 33 GHz and a realized gain of 11dB are obtained from simulation, without much variation, for the antenna when adding the periodic structure.
Applied the Technology Acceptance Model to Survey the mobile-learning adoption behavior in Science Museum (2015)

Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT: The concept of mobile learning was proposed by Revans from England in 1982 which has been more than 25 years (Revans, 1982). Revans offers an iterative model, successively alternating experience and preparation/reflection, which is a useful paradigm for mobile learning (McDermott et al., 2000). However, scholars perceive mobile learning in different ways. The following section contributes to various explanations of mobile learning by international scholars: m-learning is e-learning through mobile computational devices: Palms, Windows CE machines, even your digital cell phone (Quin, 2001). Mobile learning is a context-based learning by using mobile technology medium and is learner-centered. The flexibility of mobile learning in a proper location allow learners to interact with other learners and instructors and conduct technology-learning, content learning or context-based learning that is proactive, instant, distant /approximate, individual or group-centered. Moreover, learner will experience meaningful knowledge construction through this process (Young et al., 2005). Mobile learning is defined as any educational provision where the sole or dominant technologies are handheld or palmtop devices (Traxler, 2005).
A novel fully automated method for the measurement of sulphoconjugated catecholamines in urine using the Gilson ASTED‐XL sample preparation system and high‐performance liquid chromatography (1999)

Dopamine is produced in the kidney where it causes sodium excretion. Dopamine sulphate is deconjugated in vivo, and may be a physiological reservoir for this active renal dopamine. To investigate the role of dopamine and dopamine sulphate in sodium homeostasis we have developed a fully automated HPLC assay for free, total and sulphoconjugated dopamine. Using the Gilson ASTED-XL sample preparation unit, with temperature controlled racks, urinary free and total dopamine are measured pre-and post-incubation with arylsulphatase. Dopamine sulphate is calculated from the difference between free and total measurements. Acidified 24 h urines are processed automatically. Free dopamine assay follows buffering to pH 7.0, addition of internal standard, addition of EDTA to stabilize free catecholamines at neutral pH, and incubation at 37°C for 30 min. This mixture is trace enriched on a HEMA-SB TEC prior to ion-paired HPLC with amperometric detection. To measure total dopamine the entire process is automatically repeated with addition of arylsulphatase (400 mU/mL urine) at the beginning of the 37°C incubation. The working range of the assay is up to 7 µmol/L total dopamine. Within-and between-run imprecision for dopamine sulphate is less than 3 and 7% respectively. Median dopamine sulphate excretion in 12 normotensive subjects was 4.3 µmol/24 h. Copyright © 1999 John Wiley & Sons, Ltd.
Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity (2022)

Decreased BDNF and impaired TRKB signaling contribute to neurodegeneration in Alzheimer's disease (AD). We have shown previously that coumarin derivative LM-031 enhanced CREB/BDNF/BCL2 pathway. In this study we explored if LM-031 analogs LMDS-1 to -4 may act as TRKB agonists to protect SH-SY5Y cells against Aβ toxicity. By docking computation for binding with TRKB using 7,8-DHF as a control, all four LMDS compounds displayed potential of binding to domain d5 of TRKB. In addition, all four LMDS compounds exhibited anti-aggregation and neuroprotective efficacy on SH-SY5Y cells with induced Aβ-GFP expression. Knock-down of TRKB significantly attenuated TRKB downstream signaling and the neurite outgrowth-promoting effects of these LMDS compounds. Among them, LMDS-1 and -2 were further examined for TRKB signaling. Treatment of ERK inhibitor U0126 or PI3K inhibitor wortmannin decreased p-CREB, BDNF and BCL2 in Aβ-GFP cells, implicating the neuroprotective effects are via activating TRKB downstream ERK, PI3K-AKT and CREB signaling. LMDS-1 and -2 are blood-brain barrier permeable as shown by parallel artificial membrane permeability assay. Our results demonstrate how LMDS-1 and -2 are likely to work as TRKB agonists to exert neuroprotection in Aβ cells, which may shed light on the potential application in therapeutics of AD.
Programmiersprachen (1999)

Eine Programmiersprache ist eine zum Formulieren von Programmen geschaffene künstliche Sprache. In diesem Kapitel werden zunächst verschiedene Klassifikationen vorgestellt. Anschließend wird kurz erläutert, welche Aspekte bei der Definition einer Programmiersprache von Bedeutung sind. Detaillierter wird auf die Syntax von Programmiersprachen eingegangen.
Synthesis of Tin Catalyzed Silicon and Germanium Nanowires in a Solvent–Vapor System and Optimization of the Seed/Nanowire Interface for Dual Lithium Cycling (2013)

Silicon and germanium nanowires are grown in high density directly from a tin layer evaporated on stainless steel. The nanowires are formed in low cost glassware apparatus using the vapor phase of a high boiling point organic solvent as the growth medium. HRTEM, DFSTEM, EELS, and EDX analysis show the NWs are single crystalline with predominant ⟨111⟩ growth directions. Investigation of the seed/nanowire interface shows that in the case of Si an amorphous carbon interlayer occurs that can be removed by modifying the growth conditions. Electrochemical data shows that both the tin metal catalyst and the semiconductor nanowire reversibly cycle with lithium when the interface between the crystalline phases of the metal and semiconductor is abrupt. The dually active nanowire arrays were shown to exhibit capacities greater than 1000 mAh g–1 after 50 charge/discharge cycles.
Replacement of spatial axis with temporal axis (1996)

We point out that some of technologies and instruments can be understood by replacing spatial axis with temporal axis.
A Chemical Model for Redox Regulation of Protein Tyrosine Phosphatase 1B (PTP1B) Activity (2005)

Growing evidence indicates that endogenously produced hydrogen peroxide acts as a cellular signaling molecule that (among other things) can regulate the activity of some protein phosphatases. Recent X-ray crystallographic studies revealed an unexpected chemical transformation underlying the redox regulation of protein tyrosine phosphatase 1B, in which oxidative inactivation of the enzyme yields an intrastrand protein cross-link between the catalytic cysteine residue and its neighboring amide nitrogen. This work describes a small organic molecule that serves as an effective model for the redox-sensing assembly of functional groups at the active site of PTP1B. Findings obtained using this model system suggest that the oxidative transformation of PTP1B to its "crosslinked" inactive form can proceed directly via oxidation of the active-site cysteine to a sulfenic acid (RSOH). The remarkably facile nature of this protein cross-link-forming reaction, along with the widespread cellular occurrence of protein sulfenic acids generated via oxidation of cysteine residues, suggests that the type of oxidative protein cross-link formation first seen in the context of PTP1B represents a potentially general mechanism for redox "switching" of protein function. Thus, the chemistry characterized here could have broad relevance to both redox-regulated signal transduction and the toxic effects of oxidative stress.
Estimation and detection issues in matched-field processing (1993)

A conceptual framework in which the model-based, space-time acoustic signal processing procedure known as matched field processing (MFP) can be handled in a consistent manner is established. A framework for strong-signal MFP based on standard statistical estimation theory, in which MFP is regarded as essentially an estimation problem in the strong-signal regime, is developed. In the weak-signal case, the necessary requirement of detection dictates that MFP then be considered a joint detection-estimation task. It is demonstrated that, generally, MFP is essentially a space-time processing problem rather than simply an array processing (spatial processing only) procedure. An overview of the processing schemes used to date in MFP is given, showing how these methods relate to the optimal space-time structure. Weak-signal detection and estimation scenarios relevant to MFP are then noted. Present methods for dealing with the inherent instability of MFP algorithms (mismatch) are discussed. The current status of MFP is summarized, and recommendations for future research are made.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A step towards an artificial skin: a novel supermacroporous anisotropic cryogel for wound healing applications (2010)

Objectives: Various artificial skin products are available to the surgeon; however they are not used extensively in the clinic, mainly due to their low efficiency or high cost. To address these limitations we have produced a novel supermacroporous gelatine cryogel scaffold with a highly sophisticated ordered anisotropic pore structure. The material was characterized and assessed in vitro for its skin substitution potential. Methods: The cryogel was characterized morphologically by confocal laser scanning and scanning electron microscopy. The dynamic elasticity and viscosity were assessed to characterize its mechanical properties. The cryogel was seeded with primary human fibroblasts or keratinocytes to assess its cytotoxicity and biocompatibility. The rates of cellular migration, proliferation and protein deposition were assessed immunohistochemically over a 28-day period. Keratinocytes were also seeded onto the cryogel scaffold to assess the ability to form a bilayered artificial skin. The performances of a gelatin cryogel were compared with those of a commercially available dermal regeneration template, Integra®. Results: The gelatin cryogel scaffold demonstrated a supermacroporous, highly sophisticated, ordered, anisotropic pore structure. The material was mechanically similar to Integra®. The cryogel was found to be biocompatible and non-toxic to human skin cells, supporting active cellular migration and proliferation. The keratinocytes formed a continuous differentiated layer on the surface of the gelatine cryogel scaffold, mimicking the native skin bilayered structure. Conclusions: The large size of interconnected gradient pores, biocompatibility and small production costs of gelatine cryogels make them a promising material for tissue engineering and regenerative medicine, to treat burns and chronic wounds.
Nuclear receptor co-repressor NCOR2 and its relation to GPER with prognostic impact in ovarian cancer (2023)

Abstract Purpose The significance of the non-classical G-protein coupled estrogen receptor (GPER) as positive or negative prognostic factor for ovarian cancer patients remains still controversial. Recent results indicate that an imbalance of both co-factors and co-repressors of nuclear receptors regulate ovarian carcinogenesis by altering the transcriptional activity through chromatin remodeling. The present study aims to investigate whether the expression of the nuclear co-repressor NCOR2 plays a role in GPER signaling which thereby could positively impact overall survival rates of ovarian cancer patients. Methods NCOR2 expression was evaluated by immunohistochemistry in a cohort of 156 epithelial ovarian cancer (EOC) tumor samples and correlated to GPER expression. The correlation and differences in clinical and histopathological variables as well as their effect on prognosis was analyzed by Spearman´s correlation, Kruskal-Wallis-test and Kaplan-Meier-estimates. Results Histologic subtypes were associated with different NCOR2 expression patterns. More specifically, serous and mucinous EOC demonstrated a higher NCOR2 expression ( P = 0.008). In addition, high nuclear NCOR2 expression correlated significantly with high GPER expression (cc = 0.245, P = 0.008). A combined evaluation of both, high NCOR2 (IRS &gt; 6) and high GPER (IRS &gt; 8) expression revealed an association of a significantly improved overall survival (median OS 50.9 versus 105.1 months, P = 0.048). Conclusion Our results support the hypothesis that nuclear co-repressors such as NCOR2 may influence the transcription of target genes in EOC such as GPER. Understanding the role of nuclear co-repressors on signaling pathways will allow a better understanding of the factors involved in prognosis and clinical outcome of EOC patients.
GIS ECOBAG : Programme P1 Hydro-écologie du fleuve Garonne à l'étiage : évaluation de la capacité d'assimilation de l'hydrosystème Garonne à l'étiage, contribution à sa modélisation hydro-écologique (1999)

[Departement_IRSTEA]GMA [TR1_IRSTEA]GMA3-Altérations physico-chimiques et biologiques des écosystèmes d'eau courante [Coll_IRSTEA]Etude Cemagref, Groupement de Bordeaux, n° 34
ChemInform Abstract: A Simple One‐Pot Synthesis of Silylated and Acylated Cyanohydrins. (1987)

Abstract Carbonyl compounds (I) react with chlorotrimethylsilane (II) or the acyl chlorides (IV) in the presence of lithium cyanide to produce the silylated or acylated cyanohydrins (III) and (V) respectively.
A bioinspired recursive analog VLSI network for 3D spatiotemporal receptive fields (2006)

This work presents the use of a two-layered recursive network to produce biomimetic visual spatiotemporal bandpass receptive fields. Simulation results of the transistor network based on an array of spatially coupled polyphase Gm-C filters are also included. Our bioinspired approach captures the essence of efficient processing in recursive cortical networks and at the same time backed by the vigorous analytical tools found in cellular neural network theory within the CAS community.
RRAM-based 7T1R nonvolatile SRAM with 2x reduction in store energy and 94x reduction in restore energy for frequent-off instant-on applications (2015)

This study proposes a 7T1R nonvolatile SRAM (nvSRAM) to 1) reduce store energy by using a single NVM device, 2) suppress DC-short current during restore operations through the use of a pulsed-overwrite (POW) scheme, and 3) achieves high restore yield by using a differentially supplied initialization (DSI) scheme. This initialization-and-overwrite (IOW) 7T1R nvSRAM improves breakeven-time (BET) by 6+x, compared to previous nvSRAMs. We fabricated a 16Kb IOW-7T1R nvSRAM using HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> RRAM and a 90nm process. This represents the first ever silicon verified single-NVM nvSRAM macro. Measurements obtained in test-mode confirm that the proposed nvSRAM reduces store energy by 2x and restore energy by 94x, compared to 2R-based nvSRAMs.
Frequency of Immune Thrombocytopenia in Newborns: A Prospective Study (1997)

Thrombocytopenia is a common condition in distressed newborns, but little is known about thrombocytopenia in an unselected cohort of neonates. In an attempt to address this issue, a multicenter prospective study was conducted in three obstetrical wards of AP-HP in Paris. We found the frequency of neonatal thrombocytopenia (<150 x 10(9)/L) to approximate 0.9% (48 of 5,632 appropriate samples). An immune mechanism was likely to be the cause of thrombocytopenia in 10 of the 33 cases studied, implying an incidence of 0.3% of immune neonatal thrombocytopenia in the general population. The frequency of alloimmune thrombocytopenia was 1.5/1,000 liveborn neonates, and 1/1,000 when considering anti-HPA-1a allo-immunization. Because thrombocytopenia, whatever its cause, was often silent and delayed, it appears that the only way to detect neonatal thrombocytopenia in time to prevent its potential disastrous complications would be to perform a systematic neonatal blood sampling for platelet count. All cases of ascertained thrombocytopenia should then be screened for an immune mechanism to enable early detection of autoimmune diseases in mothers and careful monitoring of subsequent pregnancies and deliveries, leading to appropriate prevention of potential severe deleterious effects in the offspring.
Beyond 5G URLLC Evolution: New Service Modes and Practical\n Considerations (2021)

Ultra-reliable low latency communications (URLLC) arose to serve industrial\nIoT (IIoT) use cases within the 5G. Currently, it has inherent limitations to\nsupport future services. Based on state-of-the-art research and practical\ndeployment experience, in this article, we introduce and advocate for three\nvariants: broadband, scalable and extreme URLLC. We discuss use cases and key\nperformance indicators and identify technology enablers for the new service\nmodes. We bring practical considerations from the IIoT testbed and provide an\noutlook toward some new research directions.\n