gebhart/patrepeval huggingface dataset:
Electrical Properties of (Cr, Ti)Si<SUB>2</SUB> Resistive Films for Thermal Printing Heads (1988)

High-resistivity (Cr, Ti)Si2 thin films favorable for the resistors of thermal printing heads have been prepared by DC magnetron sputtering. The electrical resistivities of (Cr1−xTix)Si2 films show a maximum value of 60 μΩm at x=0.37, which is three times larger than that of the CrSi2 film. By heating the as-deposited (Cr0.63Ti0.37)Si2 film up to 723 K, the resistivity increases by 15%. After it is once heated up to 723 K, there is no change in resistivity by the same heat treatment. Using the (Cr0.63Ti0.37)Si2 film, the resistors of thermal heads with an Al electrode and a SiO2 protective layer were constructed for the wax transfer printing. The resistors have a sufficient lifetime for the pulsed-current load test.Devising the shape of the resistors, the half-tone printing covering a wide range of optical densities divided into 32 steps has been achieved.
An Object-Oriented Language for Real-Time Systems (2004)

AbstractThis article presents a description of the Hard Real-time C+ + language (HRTC++ ) for real-time programming, incorporating timing constraints in a manner consistent with the object-oriented methodology. The C+ + language is extended to accommodate real-time domain features within the encapsulation and inheritance mechanism of the language. The objective is to adopt the benefits of the object-oriented approach to the real-time area, drawing from the contributions that inheritance has rendered to the reuse and consistency of software development. A real-time preprocessor (RTPP ) is described that performs a Temporal Semantic Phase, analyzing and verifying the appropriate usage of the C+ + extensions and their translation to a suitable form for real-time feasibility and schedulability analysis.
Synthesis and bioevaluation of alkyl 2‐cyanoacryloyl glycolates as potential soft tissue adhesives (1986)

A series of alkyl 2-cyanoacryloyl glycolate tissue adhesives were synthesized and characterized by NMR. Physical properties and bond strengths are presented. Within the series, bond strength decreased with increasing molecular weight. Corresponding polymers were evaluated by in vitro and in vivo techniques for biocompatibility. In general, in vitro biocompatibility increased with molecular weight. Based on in vitro and in vivo results, the isobutyl and isoamyl derivatives gave polymers that were most biocompatible, however, the entire series was found to be less reactive than poly(methyl 2-cyanoacrylate) and only the isopropyl derivative polymers more reactive than poly(isobutyl 2-cyanoacrylate). Approximately one-third of the isobutyl polymer biodegraded in vivo after 6 weeks.
Development of a gene cloning system for the hydrogen-producing marine photosynthetic bacterium Rhodopseudomonas sp (1986)

Seventy-six strains of marine photosynthetic bacteria were analyzed by agarose gel electrophoresis for plasmid DNA content. Among these strains, 12 carried two to four different plasmids with sizes ranging from 3.1 to 11.0 megadaltons. The marine photosynthetic bacterium Rhodopseudomonas sp. NKPB002106 had two plasmids, pRD06S and pRD06L. The smaller plasmid, pRD06S, had a molecular weight of 3.8 megadaltons and was cut at a single site by restriction endonucleases SalI, SmaI, PstI, XhoI, and BglII. Moreover, the marine photosynthetic bacterium Rhodopseudomonas sp. NKPB002106 containing plasmid pRD06 had a satisfactory growth rate (doubling time, 7.5 h), a hydrogen-producing rate of 0.96 mumol/mg (dry weight) of cells per h, and nitrogen fixation capability. Plasmid pRD06S, however, had neither drug resistance nor heavy-metal resistance, and its copy number was less than 10. Therefore, a recombinant plasmid consisting of pRD06S and Escherichia coli cloning vector pUC13 was constructed and cloned in E. coli. The recombinant plasmid was transformed into Rhodopseudomonas sp. NKPB002106. As a result, Rhodopseudomonas sp. NKPB002106 developed ampicillin resistance. Thus, a shuttle vector for gene transfer was constructed for marine photosynthetic bacteria.
TOWARDS THE PREDICTION OF COMPLETE PROTEIN–PROTEIN INTERACTION NETWORKS (2001)

We present a statistical method for the prediction of protein--protein interactions within an organism. This approach is based on the treatment of proteins as collections of conserved domains, where each domain is responsible for a specific interaction with another domain. By characterizing the frequency with which specific domain--domain interactions occur within known interactions, our model can assign a probability to an arbitrary interaction between any two proteins with defined domains. Domain interaction data is complemented with information on the topology of a network and is incorporated into the model by assigning greater probabilities to networks displaying more biologically realistic topologies. We use Markov chain Monte Carlo techniques for the prediction of posterior probabilities of interaction between a set of proteins; allowing its application to large data sets. In this work we attempt to predict interactions in a set of 40 human proteins, known to form a connected network, and discuss methods for future improvement.
Target recognition by vibration frequency analysis: a comparison of laser vibrometry and acoustic methods (2003)

Target recognition is an important issue on the military battlefield. Vibration signatures are robust and independent on target orientation. Hence, they are interesting to use for classification and identification of targets. Various sensors can be used to measure signatures induced by target vibrations, such as laser vibrometry and acoustic sensors. The output from both sensors can be presented as a frequency spectrum that represents the target vibrations. A field trial was conducted where some military targets were investigated. Simultaneous data were taken with two sensors: i) a laser vibrometry system consisting of a 1.55 &#956;m eye-safe coherent laser radar; and ii) an acoustic data logging system with Bruel & Kjaer free field microphone and amplifier as the sensor part. The range to the targets was between 25 and 100 meters. Results from the field trial are reported and a comparison of the data from the sensors is presented.
Implementing wireless networks with transition mechanisms (2003)

The deployment of wireless networks based on IPv4 is spreading quickly all over the world. However, there is a strong shortage of public IPv4 addresses. Because of this, IPv6 has recently, received a new push of development. Most of the advances related to IPv6 are concerned to the development of transition mechanisms allowing IPv6 hosts to communicate through an existing IPv4 infrastructure or yet, permitting the communication between IPv4 and IPv6 hosts. This paper addresses the issue of using private IP addresses for implementing Mobile IP in wireless networks using IPv4/IPv6 transition mechanisms. An overview of the published IPv4/IPv6 transition mechanisms is presented, then, a new mechanism, called Transparent IPv6, which combines features of existing mechanisms, is proposed. The Transparent IPv6 mechanism consists in virtually assigning IPv6 addresses to IPv4 hosts without modifying user devices. This technique could be used to permit the deployment of wireless networks without requiring public IPv4 addresses, using legacy IPv4 equipments.
Development of virtual reality bike with cylindrical MR fluid brake (2012)

Cycling is a healthy and moderate aerobic exercise for the elderly and it works well not only to their physical functions but also to their mentalities. In order for the exercise machine that can facilitate the moderate aerobic exercise for users who cannot do real cycling, we have developed the virtual reality bike (VR Bike) with a cylindrical MR fluid brake. The aim of this paper is to describe (1) the development and integration of the total system of the VR Bike, and (2) the implementation of the controller for the pedaling torque in the straightway driving with slopes. The cylindrical MR fluid brake was connected to the pedal of a belt-driven bicycle and used to control pedal resistances depending on the environment of the virtual world. We formulated the torque characteristics of the brake and controlled the pedaling torque with the input current. Data of a 3D map were loaded in the VR Bike system and a subject ride a bike in the virtual world. The main controller calculated the dynamics of the bike and determined the pedaling resistance. Time profiles of the traveling speed and pedal torque during climbing up and down the slope were evaluated. Though quantitative evaluation has not conducted, the proposed system changes the pedal resistance depending on the conditions of the bike.
A Similarity Measure for Automatic Audio Classification (1997)

This paper presents recent results using statistics generated by a MMI-supervised vector quantizer as a measure of audio similarity. Such a measure has proved successful for talker identification, and the extension from speech to general audio, such as music, is straightforward. A classifier that distinguishes speech from music and non-vocal sounds is presented, as well as experimental results showing how perfect classification accuracy may be achieved on a small corpus using substantially less than two seconds per test audio file. The techniques a presented here may be extended to other applications and domains, such as audio retrieval-by-similarity,musical genre classification, and automatic segmentation of continuous audio.
High Intensity Supersonic Molecular Beam Apparatus (1964)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation R. Campargue; High Intensity Supersonic Molecular Beam Apparatus. Rev. Sci. Instrum. 1 January 1964; 35 (1): 111–112. https://doi.org/10.1063/1.1718676 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioReview of Scientific Instruments Search Advanced Search |Citation Search
NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia (2021)

Benign prostatic hyperplasia (BPH) is a quite common illness but its etiology and mechanism remain unclear. Neural epidermal growth factor-like like 2 (NELL2) plays multifunctional roles in neural cell growth and is strongly linked to the urinary tract disease. Current study aims to determine the expression, functional activities and underlying mechanism of NELL2 in BPH. Human prostate cell lines and tissues from normal human and BPH patients were utilized. Immunohistochemical staining, immunofluorescent staining, RT-polymerase chain reaction (PCR) and Western blotting were performed. We further generated cell models with NELL2 silenced or overexpressed. Subsequently, proliferation, cycle, and apoptosis of prostate cells were determined by cell counting kit-8 (CCK-8) assay and flow cytometry analysis. The epithelial-mesenchymal transition (EMT) and fibrosis process were also analyzed. Our study revealed that NELL2 was up-regulated in BPH samples and localized in the stroma and the epithelium compartments of human prostate tissues. NELL2 deficiency induced a mitochondria-dependent cell apoptosis, and inhibited cell proliferation via phosphorylating extracellular signal-regulated kinase 1/2 (ERK1/2) activation. Additionally, suppression of ERK1/2 with U0126 incubation could significantly reverse NELL2 deficiency triggered cell apoptosis. Consistently, overexpression of NELL2 promoted cell proliferation and inhibited cell apoptosis. However, NELL2 interference was observed no effect on EMT and fibrosis process. Our novel data demonstrated that up-regulation of NELL2 in the enlarged prostate could contribute to the development of BPH through enhancing cell proliferation and inhibited a mitochondria-dependent cell apoptosis via the ERK pathway. The NELL2-ERK system might represent an important target to facilitate the development of future therapeutic approaches in BPH.
Content Delivery Network Interconnection (CDNI) Request Routing Extensions (2020)

Open Caching architecture is a use case of Content Delivery Networks
Interconnection (CDNI) in which the commercial Content Delivery
Network (CDN) is the upstream CDN (uCDN) and the ISP caching layer
serves as the downstream CDN (dCDN). The extensions specified in this
document to the CDNI Metadata Interface (MI) and the Footprint and
Capabilities Interface (FCI) are derived from requirements raised by
Open Caching but are also applicable to CDNI use cases in general.
Architecture framework for business components (2002)

The term business component has become a prominent buzzword in the IS professional lingo. Component based software engineering promises to be the next breakthrough in controlling the exploding complexity and cost of systems development and maintenance. However, there is no agreed upon model that defines what these components are, how they fit into the overall OO domain, and how they relate to systems architectures. There are also very few, if any, software frameworks developed to support construction of systems from business components. The paper first introduces a business component model and then describes a particular software framework. The framework has been developed at System Software Associates and supports construction of system from software components implementing well articulated and reusable business concepts.
Rhodium-Catalyzed Double [2 + 2 + 2] Cycloaddition of 1,4-Bis(diphenylphosphinoyl)buta-1,3-diyne with Tethered Diynes:  A Modular, Highly Versatile Single-Pot Synthesis of NU-BIPHEP Biaryl Diphosphines (2007)

Rhodium-catalyzed double [2 + 2 + 2] cycloaddition of 1,4-bis(diphenylphosphinoyl)buta-1,3-diyne with tethered diynes provides a straightforward, single-pot procedure for the synthesis of a new class of tropos biaryl diphosphine, NU-BIPHEP. This methodology represents a significant improvement on existing multistep procedures. Enantiopure Lewis acid platinum complexes of these diphosphines are highly efficient catalysts for carbonyl-ene and Diels-Alder reactions, and ruthenium diphosphine-diamine complexes catalyze the asymmetric reduction of ketones to give ee's that rival those obtained with their BINAP counterpart.
Metallaphotoredox Difluoromethylation of Aryl Bromides (2018)

Herein, we report a convenient and broadly applicable strategy for the difluoromethylation of aryl bromides by metallaphotoredox catalysis. Bromodifluoromethane, a simple and commercially available alkyl halide, is harnessed as an effective source of difluoromethyl radical by silyl-radical-mediated halogen abstraction. The merger of this fluoroalkyl electrophile activation pathway with a dual nickel/photoredox catalytic platform enables the difluoromethylation of a diverse array of aryl and heteroaryl bromides under mild conditions. The utility of this procedure is showcased in the late-stage functionalization of several drug analogues.
Molecular Characterization of Striated Muscle-Specific Gab1 Isoform as a Critical Signal Transducer for Neuregulin-1/ErbB Signaling in Cardiomyocytes (2016)

Grb2-associated binder (Gab) docking proteins regulate signals downstream of a variety of growth factors and receptor tyrosine kinases. Neuregulin-1 (NRG-1), a member of epidermal growth factor family, plays a critical role for cardiomyocyte proliferation and prevention of heart failure via ErbB receptors. We previously reported that Gab1 and Gab2 in the myocardium are essential for maintenance of myocardial function in the postnatal heart via transmission of NRG-1/ErbB-signaling through analysis of Gab1/Gab2 cardiomyocyte-specific double knockout mice. In that study, we also found that there is an unknown high-molecular weight (high-MW) Gab1 isoform (120 kDa) expressed exclusively in the heart, in addition to the ubiquitously expressed low-MW (100 kDa) Gab1. However, the high-MW Gab1 has been molecularly ill-defined to date. Here, we identified the high-MW Gab1 as a striated muscle-specific isoform. The high-MW Gab1 has an extra exon encoding 27 amino acid residues between the already-known 3rd and 4th exons of the ubiquitously expressed low-MW Gab1. Expression analysis by RT-PCR and immunostaining with the antibody specific for the high-MW Gab1 demonstrate that the high-MW Gab1 isoform is exclusively expressed in striated muscle including heart and skeletal muscle. The ratio of high-MW Gab1/ total Gab1 mRNAs increased along with heart development. The high-MW Gab1 isoform in heart underwent tyrosine-phosphorylation exclusively after intravenous administration of NRG-1, among several growth factors. Adenovirus-mediated overexpression of the high-MW Gab1 induces more sustained activation of AKT after stimulation with NRG-1 in cardiomyocytes compared with that of β-galactosidase. On the contrary, siRNA-mediated knockdown of the high-MW Gab1 significantly attenuated AKT activation after stimulation with NRG-1 in cardiomyocytes. Taken together, these findings suggest that the striated muscle-specific high-MW isoform of Gab1 has a crucial role for NRG-1/ErbB signaling in cardiomyocytes.
Fast Gain Control in an Erbium-Doped Fiber Amplifier (1996)

In a recent study1 power transients in chains of highly pumped, deeply saturated erbium-doped fiber amplifiers (EDFA’s) were demonstrated to occur on time scales much faster than those for an individual amplifier.
FLOW ANDDISPERSION INURBANAREAS (2002)

▪ Abstract Increasing urbanization and concern about sustainability and quality of life issues have produced considerable interest in flow and dispersion in urban areas. We address this subject at four scales: regional, city, neighborhood, and street. The flow is one over and through a complex array of structures. Most of the local fluid mechanical processes are understood; how these combine and what is the most appropriate framework to study and quantify the result is less clear. Extensive and structured experimental databases have been compiled recently in several laboratories. A number of major field experiments in urban areas have been completed very recently and more are planned. These have aided understanding as well as model development and evaluation.
An Alzheimer's Disease-Linked Loss-of-Function CLN5 Variant Impairs Cathepsin D Maturation, Consistent with a Retromer Trafficking Defect (2018)

In a whole-exome sequencing study of multiplex Alzheimer's disease (AD) families, we investigated three neuronal ceroid lipofuscinosis genes that have been linked to retromer, an intracellular trafficking pathway associated with AD: ceroid lipofuscinosis 3 (CLN3), ceroid lipofuscinosis 5 (CLN5), and cathepsin D (CTSD). We identified a missense variant in CLN5 c.A959G (p.Asn320Ser) that segregated with AD. We find that this variant causes glycosylation defects in the expressed protein, which causes it to be retained in the endoplasmic reticulum with reduced delivery to the endolysosomal compartment, CLN5's normal cellular location. The AD-associated CLN5 variant is shown here to reduce the normal processing of cathepsin D and to decrease levels of full-length amyloid precursor protein (APP), suggestive of a defect in retromer-dependent trafficking.
Isolated thrombocytopenia in patients infected with HIV: Treatment with intravenous gammaglobulin (1988)

Isolated thrombocytopenia occurs frequently in patients infected with HIV. Studies of mechanisms of thrombocytopenia and clinical response to therapy suggest that the thrombocytopenia is often antibody mediated (ITP). The best approach to treatment of these patients is uncertain in that the routine modalities (steroids, splenectomy, vinca alkaloids) that are used to increase the platelet count in patients with classic ITP are known to be immunosuppressive. We report here the results of intravenous gammaglobulin (IVGG) treatment of 22 patients with HIV-related acute and chronic ITP who had severe thrombocytopenia and bleeding symptoms. Only one patient had an opportunistic infection at the time of treatment. Eight patients were homosexual, eight had hemophilia, three were i.v. drug abusers, two children had congenital acquisition of HIV, and one was the wife of an HIV + i.v. drug abuser. The average pretreatment platelet count was 22,000/microliter (hemophiliacs were treated at higher platelet counts than were the other patients), and the mean peak platelet count measured on days 5 to 8 was 182,000/microliter. Nineteen of 22 patients had peak platelet counts greater than 50,000/microliter following IVGG and 17/22 had peak counts greater than 100,000/microliter. After the initial infusions, all but three refractory patients could maintain adequate platelet counts with IVGG alone infused no more often than once every 2 weeks. The outcomes for the 22 patients after multiple maintenance IVGG infusions were remission, 5; stable without therapy, 1; maintenance, 13; and refractory, 3. The eight hemophiliacs with ITP responded better than did the eight homosexual ITP patients; their mean peak platelet count was 227,000/microliter versus 142,000/microliter in the homosexuals. In summary, patients with HIV-related ITP without opportunistic infections responded well to IVGG, with peak platelet counts comparable to those of ITP patients not infected with HIV. IVGG may be a useful therapy of ITP in HIV+ patients, since it appears to be less immunosuppressive than are conventional therapies, and none of the 22 HIV+ patients developed an opportunistic infection while receiving IVGG alone.
Anionic Fries' Type Reaction in Aryl Tetramethyldiamidophosphates (1992)

Abstract N-BuLi lithiates aryl tetramethyldiamidophosphates adjacent to the tetramethyldiamidophosphate group, which migrates to the adjacent position.
A ±5-V CMOS analog multiplier (1987)

A four-quadrant CMOS analog multiplier is presented. The device is nominally biased with /spl plusmn/5-V supplies, has identical full-scale single-ended x and y inputs of /spl plusmn/4 V, and exhibits less than 0.5% nonlinear error at 75% of full-scale swing. Operation with supplies as low as /spl plusmn/2.5 V is also possible. A comparison of theoretical and experimental results obtained from fabrication of the multiplier in a 3-/spl mu/m p-well CMOS process is made.
A novel method based on a Mask R-CNN model for processing dPCR images (2019)

The flow of Mask R-CNN model for processing digital polymerase chain reaction (dPCR) fluorescence images.
Seed Dormaney in Acer: Maturation in Relation to Dormancy inAcer PseudoplatanusL (1973)

Maturation of Acer pseudoplatanus seeds comprises three phases. The first is a growth phase lasting for about 100 d, during which fresh weight and dry weight increase steadily. The end of the growth phase is marked by a temporary cessation of weight increase and is followed by a phase of reserve accumulation extending for a further 60 d. During this phase levels of extractable lipid, soluble and insoluble carbohydrate, protein, and membrane-bound ribosomes show a marked increase. The third phase is a period of desiccation, lasting at least 30 d. The kind of dormancy exhibited by the immature seed is characteristic of the stage of maturation. Before the desiccation phase the embryo has no capacity for germination even when subjected to treatments known to promote germination in the mature seed. In the desiccation phase the seed becomes responsive to chilling, but a wide range of hormones and other substances known to promote seed germination are ineffective. Embryos contain a persistently high level of acidic inhibitors throughout maturation. The level of neutral inhibitors, initially high, showed a marked drop after 150 d and remained low for the rest of the maturation period.