gebhart/patrepeval huggingface dataset:
QUANTITATIVE MICROBIAL RISK ASSESSMENT OF FERMENTED BEAN PASTES CONTAMINATED WITH CLOSTRIDIUM PERFRINGENS (2021)

This study evaluated Clostridium perfringens risk in fermented bean pastes. The prevalence in fermented bean pastes, development of the predictive model, temperature, time, and consumption data were investigated. A simulation model was prepared in @RISK with the obtained data to calculate the probability of foodborne C. perfringens foodborne illness from fermented bean paste consumption. Only 74 of the 1,097 samples were positive for C. perfringens. The initial contamination level was estimated to be 0.7 log CFU/g. It showed the probability of foodborne C. perfringens infection per person per day upon consumption of fermented bean pastes was 8.0×10−12, which is considered low risk.
Nanoscale interfacial engineering enables highly stable and efficient perovskite photovoltaics (2021)

We present a facile molecular-level interface engineering strategy to augment the long-term operational and thermal stability of perovskite solar cells (PSCs) by tailoring the interface between the perovskite and hole transporting layer (HTL) with a multifunctional ligand 2,5-thiophenedicarboxylic acid. The solar cells exhibited high operational stability (maximum powering point tracking at one sun illumination) with a stabilized <i>T</i> <sub>S80</sub> (the time over which the device efficiency reduces to 80% after initial burn-in) of ≈5950 h at 40 °C and a stabilized power conversion efficiency (PCE) over 23%. The origin of high device stability and performance is correlated to the nano/sub-nanoscale molecular level interactions between ligand and perovskite layer, which is further corroborated by comprehensive multiscale characterization. These results provide insights into the modulation of the grain boundaries, local density of states, surface bandgap, and interfacial recombination. Chemical analysis of aged devices showed that molecular passivation suppresses interfacial ion diffusion and inhibits the photoinduced I<sub>2</sub> release that irreversibly degrades the perovskite. The interfacial engineering strategies enabled by multifunctional ligands can expedite the path towards stable PSCs.
Solar Hydrogen Productivity of Ceria–Scandia Solid Solution Using Two-Step Water-Splitting Cycle (2012)

The reactivity of CeO2–Sc2O3 solid solution for solar hydrogen production via two-step water-splitting reaction has been studied in this work. The CeO2–Sc2O3 solid solution was synthesized by polymerized complex method (PCM) with various Sc content between 0 and 20 mol. %. Analysis results from online direct gas mass spectrometry (DGMS) suggest that Ce3 + formed by CeO2–Sc2O3 solid solution in the O2-releasing step could be completely oxidized by H2O to generate hydrogen and return to Ce4 + in the H2-generation step. A Ce0.97Sc0.03O1.985 generates the largest amount of O2 and H2 among present samples, and the reduction and oxidation ratios are about 9.9% (Ce) and 10% (Ce), respectively. An estimated H2-generation reaction rate is about 4 ml g−1min−1 for Ce0.97Sc0.03O1.985. This value is about seven times greater than that of Ce0.89Zr0.11O2. The high reaction rate of Ce0.97Sc0.03O1.985 makes all formed Ce3 + completely oxidized by H2O in 5 min in the H2-generation step. The reasons for high performance are discussed from the views of lattice distortion and the amount of oxygen vacancies formed in the lattice.
Local Discontinuous Galerkin methods for fractional diffusion equations (2013)

We consider the development and analysis of local discontinuous Galerkin methods for fractional diffusion problems in one space dimension, characterized by having fractional derivatives, parameterized by β ∈[1, 2]. After demonstrating that a classic approach fails to deliver optimal order of convergence, we introduce a modified local numerical flux which exhibits optimal order of convergence 𝒪(hk + 1) uniformly across the continuous range between pure advection (β = 1) and pure diffusion (β = 2). In the two classic limits, known schemes are recovered. We discuss stability and present an error analysis for the space semi-discretized scheme, which is supported through a few examples.
The transport of a reversible proton pump antagonist, 5, 6-dimethyl-2-(4-Fluorophenylamino)-4-(1-methyl-1,2,3, 4-tetrahydroisoquinoline-2-yl) pyrimidine hydrochloride (YH1885), across caco-2 cell monolayers. (2001)

5,6-Dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3, 4-tetrahydroisoquinoline-2-yl) pyrimidine hydrochloride (YH1885) is under development as a novel acid pump antagonist by Yuhan Research Center. Previous studies have suggested that the AUC and C(max) of orally dosed YH1885 are dose-dependent in the range of 2 to 500 mg/kg. The objective of the present study was to investigate the absorption mechanism of YH1885 using a human colon carcinoma cell line, Caco-2. The cells were grown to confluency on a permeable polycarbonate membrane insert to permit loading of YH1885 on either the apical or basolateral side of the cell monolayer. The flux across the monolayer from the apical to basolateral side was 3 to 5 times greater than that from the basolateral to apical side. The uptake of YH1885 into the Caco-2 cell monolayer was saturable and appeared to be mediated by a high-affinity transporter, with an apparent K(m) of 1.47+/-0.21 microM and a V(max) of 25.14+/-1.16 pmol/cm(2)/40 s. The apical to basolateral transport across the monolayer was Na(+)-independent, H(+)-sensitive, and energy-dependent. The transport was inhibited significantly by the presence of structural analogs of YH1885 (e.g., YH957, YH1070, and YH1041), some pyrimidine nucleobases (uracil and 5-methyluracil), and nucleobase transport inhibitors (e.g., papaverine, dipyridamole, and phloridzin). These results demonstrate that the apical to basolateral transport of YH1885 across the Caco-2 cell monolayer is partially mediated by a nucleobase transport system, which exhibits high-affinity and energy-dependent properties for YH1885. Saturation of this transport system, in addition to the limited solubility of YH1885 (i.e., approximately 5.3 microM), appears to contribute to the dose-dependent bioavailability of the drug.
Supplementary Table 1 from Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer (2023)

Supplementary Table 1 from Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer
Work Function and Catalytic Activity Measurements of an IrO2 Film Deposited on YSZ Subjected to In Situ Electrochemical Promotion (1998)

In order to investigate the origin of the effect of non faradaic electrochem. modification of catalytic activity (NEMCA), a Kelvin probe was used to measure in situ the changes induced in the work function of an IrO2 catalyst film deposited on yttria-stabilized zirconia upon electrochem. supply of O2- to the catalyst under reaction conditions. Ethylene oxidn. was chosen as a model reaction system. For this purpose an electrochem. reactor of novel design was used in which work function measurements could be carried out in situ during kinetic measurements. It was found that the changes in catalyst work function equal to changes in catalyst ohmic-drop-free potential and that the reaction rate depends exponentially on catalyst work function at low applied potentials. [on SciFinder (R)]
Identification and improved control of GTAW voltages utilizing digital series compensation (1980)

Present methods for automatically controlling the voltage of a Gas-Tungsten-Arc-Welding (GTAW) process utilize an analog servo system to regulate the welding electrode to workpiece distance. The controllers currently being used in this facility are characterized by large over-shoot to a step input, and steady-state error due to deadband. An attempt to use microprocessor technology to improve the performance is underway. Such a method of improving the performance of the voltage controllers has been developed using an on-line identification procedure to determine the mathematical model of the present controller. Once an adequate model has been determined, a digital compensation scheme is designed to acquire the desired performance. The identification procedure used was the Model Reference Adaptive Technique, by which a model is postulated and its performance is compared to the actual plant performance for a set of given inputs. The squared error between the plant performance and the predicted performance is then computed over the identification interval. The model parameters are adjusted by an optimization routine to improve the model of the plant. Once the model is optimized to the point of diminishing returns, a digital PI or PID controller is designed. The result is that now the machine behaves in a manner that can be easily adjusted to give significantly improved performance. A relatively inexpensive M6800 microcomputer is used for both the on-line model identification, including the error minimizing routines, and for the realization of the series compensating controller. The software used is Motorola 6800 Assembly Language and Motorola Fortran. The method of improved control is being expanded to include the other welding parameters (current and speed of torch travel) and to other methods of control and state reconstruction, such as the linear regulator and the Kalman filter. Performance comparisons between the linear regulator and PID controller are made.
Characteristic gene expression induced by polyurethane foam/spheroid culture of hepatoma cell line, Hep G2 as a promising cell source for bioartificial liver. (2007)

Hepatoma cell line, Hep G2 cells in the PUF/spheroid culture is a promising hepatocyte source for BAL. Microarray analysis revealed a number of characteristic genes altered by the PUF/spheroid.
Computer Aided Interpretation of NDE Signals (1978)

In order to improve NDE reliability, it is important to recover as much as possible of the useful information in NDE waveforms. An on-line minicomputer is ideally suited to both the collection of data and the performance of sophisticated signal processing tasks. Using a variety of signal processing techniques, including windowing, self-normalization (of transducer properties and far-field diffraction effects), transformations (Fourier magnitude and phase transforms, autocorrelations, cepstra), feature extraction and pattern· recognition, it has been possible to obtain information about very small defects, strength of adhesive bonds and acoustic emissions which are not available by conventional means. Examples of these various capabilities are given.
Flexible Superhydrophobic and Superoleophilic MoS2 Sponge for Highly Efficient Oil-Water Separation (2016)

Removal of oils and organic solvents from water is an important global challenge for energy conservation and environmental protection. Advanced sorbent materials with excellent sorption capacity need to be developed. Here we report on a superhydrophobic and superoleophilic MoS2 nanosheet sponge (SMS) for highly efficient separation and absorption of oils or organic solvents from water. This novel sponge exhibits excellent absorption performance through a combination of superhydrophobicity, high porosity, robust stability in harsh conditions (including flame retardance and inertness to corrosive and different temperature environments) and excellent mechanical properties. The dip-coating strategy proposed for the fabrication of the SMS, which does not require a complicated process or sophisticated equipment, is very straightforward and easy to scale up. This finding shows promise for water remediation and oil recovery.
CiraaS (2022)

Cloud computing reduces provider and user costs by multiplexing workloads. Advantages of cloud computing include high utilization by temporal and spatial sharing computing resources and a subscription model that charges only for the resources and time used[1]. As recent cloud computing has evolved to maximize these advantages, microservices [11], function-as-a-service (FaaS) [10], and other more granular and short-lived cloud services have emerged. Today's FaaS are oriented towards fast provisioning, fine-grained billing times, tight memory constraints, stateless processing, and real-time processing [15]. However, since the context switching in CPUs is the bottleneck [8], their processing demands are no longer satisfactorily met. Therefore, a shift is expected toward a more efficient system architecture for cloud computing [10].
Si 29 nuclear magnetic resonance of luminescent silicon (1997)

Nuclear magnetic resonance of Si29 is used to study structural properties of porous silicon and siloxene. Evidence for changes in the chemical shift of porous silicon due to quantum confinement could not be observed. A hydride phase exhibiting a chemical shift of −75 ppm versus tetramethyl silane (TMS) is found in both porous silicon and siloxene. In as-prepared Wöhler siloxene, a chemical shift of −83 ppm versus TMS is assigned to threefold coordinated Si atoms forming a planar polysilane.
Prévalence des anomalies rénales dans l’hépatite B chronique : résultats de l’étude HARPE (2012)

La prise en charge thérapeutique des néphropathies doit tenir compte de la fragilité de la personne âgée. Afin de mieux l'appréhender, des évaluations gériatriques standardisées peuvent être proposées. Elles permettent ainsi de mieux repérer les patients fragiles et de leur proposer des traitements plus adaptés, dont la iatrogénie est moindre. Cet article a pour objet de se focaliser sur les néphropathies les plus fréquentes chez les patients âgés et analyser leur prise en charge spécifique néphrogériatrique. Pour le reste, l'ensemble des néphropathies rencontrées à l'âge moyen peuvent être observées chez le sujet âgé, le plus souvent avec une présentation clinique similaire. Nous centrerons cet article sur les néphropathies les plus fréquemment et les plus spécifiquement observées chez les patients âgés (à l'exception des néphropathies associées aux gammapathies monoclonales qui sont en dehors du champ d'analyse de cette revue), ainsi que sur les particularités de prise en charge liées au grand âge.In our aging population, kidney disease management needs to take into account the frailty of the elderly. Standardized geriatric assessments can be proposed to help clinicians apprehend this dimension in their daily practice. These tools allow to better identify frail patients and offer them more personalized and harmless treatments. This article aims to focus on the kidney diseases commonly observed in elderly patients and analyze their specific nephrogeriatric care modalities. It should be noticed that all known kidney diseases can be also observed in the elderly, most often with a quite similar clinical presentation. This review is thus focused on the diseases most frequently and most specifically observed in elderly patients (except for monoclonal gammopathy associated nephropathies, out of the scope of this work), as well as the peculiarities of old age nephrological care.
Effects of signal intensity level and noise-simulated hearing loss on auditory language processing persons with aphasia (2007)

This study assessed the role of presentation level and high-frequency audibility in auditory processing of participants with aphasia (PWA). Performance of PWA was compared to non-brain-injured participants (NBIP) on the Computerized Revised Token Test (C-RTT) at varying signal intensity levels, and under normal and simulated hearing loss conditions. The PWA performed significantly more poorly than the NBIP under both conditions. Maximum performance required significantly higher presentation levels in the simulated hearing loss condition than in quiet; with similar gain and level requirements were observed for both groups. The results will be discussed relative to auditory language processing in PWA.
Fast learning of biomimetic oculomotor control with nonparametric regression networks (2002)

Accurate oculomotor control is one of the essential pre-requisites of successful visuomotor coordination. Given the variable nonlinearities of the geometry of binocular vision as well as the possible nonlinearities of the oculomotor plant, it is desirable to accomplish accurate oculomotor control through learning approaches. We investigate learning control for a biomimetic active vision system mounted on a humanoid robot. By combining a biologically inspired cerebellar learning scheme with a state-of-the-art statistical learning network, our robot system is able to acquire high performance visual stabilization reflexes after about 40 seconds of learning despite significant nonlinearities and processing delays in the system.
Unconventional Source of Neurotoxic Protein Aggregation from Organelle Off-Target Bax∆2 in Alzheimer’s Disease (2023)

Protein aggregates are a hallmark of Alzheimer’s disease (AD). Extensive studies have focused on β-amyloid plaques and Tau tangles. Here, we illustrate a novel source of protein aggregates in AD neurons from organelle off-target proteins. Bax is a mitochondrial pore-forming pro-death protein. What happens to Bax if it fails to target mitochondria? We previously showed that a mitochondrial target-deficient alternatively spliced variant, Bax∆2, formed large cytosolic protein aggregates and triggered caspase 8-mediated cell death. Bax∆2 protein levels were low in most normal organs and the proteins were quickly degraded in cancer. Here, we found that 85% of AD patients had Bax∆2 required alternative splicing. Increased Bax∆2 proteins were mostly accumulated in neurons of AD-susceptible brain regions. Intracellularly, Bax∆2 aggregates distributed independently of Tau tangles. Interestingly, Bax∆2 aggregates triggered the formation of stress granules (SGs), a large protein-RNA complex involved in AD pathogenesis. Although the functional domains required for aggregation and cell death are the same as in cancer cells, Bax∆2 relied on SGs, not caspase 8, for neuronal cell death. These results imply that the aggregation of organelle off-target proteins, such as Bax∆2, broadens the scope of traditional AD pathogenic proteins that contribute to the neuronal stress responses and AD pathogenesis.
Aspects, mechanism, and biological relevance of mitochondrial protein nitration sustained by mitochondrial nitric oxide synthase (2004)

The goal of this study was to explore the occurrence of nitrated proteins in mitochondria given that these organelles are endowed with a mitochondrial nitric oxide (NO.-) synthase and considering the important role that mitochondria have in energy metabolism. Our hypothesis is that nitration of proteins constitutes a posttranslational modification by which NO.- exhibits long-term effects above and beyond those bioregulatory ones mediated through the interaction with cytochrome c oxidase. Our studies are aimed at understanding the mechanisms underlying the nitration of proteins in mitochondria and the biological significance of such a process in the cellular milieu. On promoting a sustained NO.- production by mitochondria, we investigated various aspects of protein nitration. Among them, the localization of nitrated proteins in mitochondrial subfractions, the identification of nitrated proteins through proteomic approaches, the characterization of affected pathways, and depiction of a target sequence. The biological relevance was analyzed by considering the turnover of native and nitrated proteins. In this regard, mitochondrial dysfunction, ensuing nitrative stress, may be envisioned as the result of accumulation of nitrated proteins, resulting from an overproduction of endogenous NO.- (this study), a failure in the proteolytic system to catabolize modified proteins, or a combination of both. Finally, this study allows one to gain understanding on the mechanism and nitrating species underlying mitochondrial protein nitration.
Short and Efficient Synthesis of Coronene Derivatives via Ruthenium-Catalyzed Benzannulation Protocol (2005)

[reaction: see text] TpRuPPh3(CH3CN)2PF6 (3 mol %) was very active in catalytic benzannulation of 1-phenyl-2-ethynylbenzenes in dichloroethane (60 degrees C, 36 h) to afford phenanthrene in 95% yield. This method is applicable to the synthesis of various polycyclic aromatic hydrocarbons via two- and four-fold benzannulations, including various substituted coronene derivatives (53-86% yields) using this catalyst at a moderate loading (10 mol %).
Simultaneous control of 2DOF upper-limb prosthesis with body compensations-based control: a multiple cases study (2022)

International audience
Synaptic Plasticity in Mammalian Photoreceptors Prepared as Sheets for Retinal Transplantation (2003)

Adult photoreceptor sheets, a potential graft preparation for retinal transplantation, show a rapid retraction of axon terminals toward the cell bodies during culture. Although retraction may impede synaptic integration after transplantation, this intrinsic plasticity could be redirected to stimulate graft-host interaction.
Twelve‐week RBC storage (2003)

It is possible to store RBCs for 12 weeks with acceptable recovery and 0.6 percent hemolysis and with normal 2,3 DPG concentrations for 2 weeks.
The DoF of the asymmetric MIMO interference channel with square direct link channel matrices (2014)

This paper studies the sum Degrees of Freedom (DoF) of K-user asymmetric MIMO Interference Channel (IC) with square direct link channel matrices, that is, the u-th transmitter and its intended receiver have M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">u</sub> ϵ N antennas each, where M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">u</sub> need not be the same for all u ϵ [1 : K]. Starting from a 3-user example, it is shown that existing cooperation-based outer bounds are insufficient to characterize the DoF. Moreover, it is shown that two distinct operating regimes exist. With a dominant user, i.e., a user that has more antennas than the other two users combined, it is DoF optimal to let that user transmit alone on the IC. Otherwise, it is DoF optimal to decompose and operate the 3-user MIMO IC as an (M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> + M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> + M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> )-user SISO IC. This indicates that MIMO operations are useless from a DoF perspective in systems without a dominant user. The main contribution of the paper is the derivation of a novel outer bound for the general K-user case that is tight in the regime where a dominant user is not present; this is done by generalizing the insights from the 3-user example to an arbitrary number of users.