gebhart/patrepeval huggingface dataset:
Daily administration of MGCD265 to patients with solid tumors in a dose-escalation phase I study (study 265-101). (2010)

3106 Background: MGCD265 is an orally-available tyrosine kinase inhibitor that targets Met, VEGFR-1, -2, -3, Tie-2 and Ron. Methods: This is a multicenter, open-label, dose escalation study of oral MGCD265 administered once daily as a continuous 21-day cycle. Cohorts of 3-4 patients were enrolled per dose level, initially with dose doubling between cohorts, followed by smaller increments once grade 2 drug-related toxicity is observed. Response is assessed every 2 cycles by RECIST criteria and plasma makers (VEGF, HGF, shed Met and soluble VEGFR2) are being analyzed. Results: The first18 patients received capsules of MGCD265: 4 patients at 24 mg/m2; 3 patients at 48 mg/m2; 4 patients at 96 mg/m2; 3 patients at 150 mg/m2 and 4 patients at 300 mg/m2. Hypertension was observed in one patient at 300 mg/m2 during the first cycle of treatment. This event was considered to be a dose limiting toxicity. Grade 2 adverse events considered at least possibly related to the treatment included: hypertension, anemia, nausea and diarrhea. A tablet formulation was recently introduced at 150 mg/m2 (n=4) and at the 250 mg/m2 dose levels. To date, 5 patients have experienced stable disease. Available archived biopsies obtained prior to MGCD265 treatment from 3 of these 5 patients showed Met protein expression and autophosphorylation. Preliminary PK data indicate a Tmax of approximately 5 hours with a long half-life (∼26 hours). PK profile from tablets and capsules appears similar based on MGCD265 clinical studies. At 150 mg/m2, the steady state plasma concentration is anticipated to be in the range of the exposure at an efficacious dose in xenograft models of Met sensitive tumors. Preliminary PD analyses indicate modulation of VEGF by MGCD265. Conclusions: To date, daily oral administration of MGCD265 has been found to be well tolerated with early signs of activity and at 150 mg/m2, the human exposure is predicted to be in the range of an efficacious dose in preclinical Met sensitive models. In the absence of significant toxicity, this dose could be considered a phase II dose. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration MethylGene MethylGene MethylGene MethylGene
Granulomatous Infectious Diseases Associated with Tumor Necrosis Factor Antagonists (2004)

The relationship between the use of tumor necrosis factor antagonists and onset of granulomatous infection was examined using data collected through the Adverse Event Reporting System of the US Food and Drug Administration for January 1998-September 2002. Granulomatous infections were reported at rates of approximately 239 per 100,000 patients who received infliximab and approximately 74 per 100,000 patients who received etanercept (P<.001). Tuberculosis was the most frequently reported disease, occurring in approximately 144 and approximately 35 per 100,000 infliximab-treated and etanercept-treated patients, respectively (P<.001). Candidiasis, coccidioidomycosis, histoplasmosis, listeriosis, nocardiosis, and infections due to nontuberculous mycobacteria were reported with significantly greater frequency among infliximab-treated patients. Seventy-two percent of these infection occurred < or =90 days after starting infliximab treatment, and 28% occurred after starting etanercept treatment (P<.001). These data indicate a risk of granulomatous infection that was 3.25-fold greater among patients who received infliximab than among those who received etanercept. The clustering of reports shortly after initiation of treatment with infliximab is consistent with reactivation of latent infection.
High-Voltage 4H-SiC Thyristors With a Graded Etched Junction Termination Extension (2011)

For the first time, a graded etched junction termination extension (JTE) is applied to completed 4H-SiC gate turn-off thyristors. These devices demonstrate the feasibility of nonimplanted high-voltage SiC thyristors. The maximal measured forward breakdown voltage of 7.8 kV corresponds very well to the ideal value of 8.1 kV. This letter explains the conceptual procedure to realize an optimal four-step JTE and compares measurement results with those obtained from finite-element simulations.
Inherent temperature compensation of fiber-optic current sensors employing spun highly birefringent fiber (2016)

We investigate the various contributions to the temperature dependence of an interferometric fiber-optic current sensor employing spun highly-birefringent sensing fiber, in particular, the contributions from the fiber retarder at the fiber coil entrance, the spun fiber's birefringence, and the Faraday effect. We theoretically and experimentally demonstrate that an appropriately designed retarder inherently compensates the temperature dependence of the fiber birefringence and the Faraday effect. We demonstrate insensitivity to temperature to within ± 0.2% between -40 and + 85 °C. Furthermore, we analyze the influence of the retarder parameters on the linearity of the recovered magneto-optic phase shift vs. current and determine a set of parameters that results in a perfectly linear relationship.
Control of Pecan Nut Casebearer in Pecans, 1996 (1997)

Abstract Three insecticides were evaluated for control of PNC on pecans. Trials were conducted at a commercial pecan orchard located near Burneyville, OK (Love Co.). A section of the pecan orchard was divided into 7 blocks of trees, with each block receiving one of the treatments. Each block was ca. one acre in size. The trial used mature native pecan trees. Pretreatment PNC infestation levels were determined on 2 Jun. Twenty nut clusters on seven trees within the treatment area were inspected for the presence of PNC eggs and damage. If an egg or damage was found on any nut within a cluster, the cluster was considered infested. Treatments were applied on 3 and 4 Jun using a FMC Model 577-CP motor driven, air-blast sprayer. The sprayer was calibrated to deliver 100 gpa. Only one application was made. PNC damage was evaluated on 24 Jun by inspecting 25 nut clusters/tree on each of 7-10 trees (175-250 nut clusters per treatment), at 5 to 8 feet above the ground for casebearer entries.
Leakage-Aware Multiprocessor Scheduling (2008)

When peak performance is unnecessary, Dynamic Voltage Scaling (DVS) can be used to reduce the dynamic power consumption of embedded multiprocessors. In future technologies, however, static power consumption due to leakage current is expected to increase significantly. Then it will be more effective to limit the number of processors employed (i.e., turn some of them off), or to use a combination of DVS and processor shutdown. In this paper, leakage-aware scheduling heuristics are presented that determine the best trade-off between these three techniques: DVS, processor shutdown, and finding the optimal number of processors. Experimental results obtained using a public benchmark set of task graphs and real parallel applications show that our approach reduces the total energy consumption by up to 46% for tight deadlines (1.5× the critical path length) and by up to 73% for loose deadlines (8× the critical path length) compared to an approach that only employs DVS. We also compare the energy consumed by our scheduling algorithms to two absolute lower bounds, one for the case where all processors continuously run at the same frequency, and one for the case where the processors can run at different frequencies and these frequencies may change over time. The results show that the energy reduction achieved by our best approach is close to these theoretical limits.
Effects of ascorbic acid and sodium ascorbate on cyclic nucleotide metabolism in human lymphocytes. (1979)

L-ascorbic acid (LAA) augmented cGMP many-fold in highly purified human peripheral blood lymphocytes. The cGMP response occurred within 10 sec and persisted for at least 60 min. D-ascorbic acid (DAA) and dehydroascorbic acid (DHAA) were also equally active in enhancing cGMP concentrations but metabolic precursors of ascorbic acid and other inorganic acids did not increase cGMP levels. Determination of the amount of DHAA contaminating the LAA precluded the possibility that it was solely responsible for the enhanced cGMP levels. The sodium or calcium salts of ascorbic acid did not increase cGMP concentrations. If these neutralized preparations were acidified, increased cGMP concentrations were then noted. In broken cell preparations, LAA, DAA, and DHAA and to a lesser extent sodium ascorbate (NaA) enhanced guanylate cyclase activity while neither inhibited cAMP or cGMP phosphodiesterase (PDE) activity. The possible role of H2O2, fatty acid liberation, prostaglandin production, oxidizing-reducing agents, and free radical formation in mediating the effects of ascorbic acid on cGMP levels were evaluated, but none of these potential mechanisms were definitively proven to be a required intermediary for the cGMP enhancing activity of ascorbic acid. LAA, DHAA or NaA did not induce lymphocyte transformation or modulate lectin-induced mitogenesis.
Organization of Ca 2+ Stores in Vascular Smooth Muscle: Functional Implications (2002)

Much evidence suggests that caffeine/ryanodine (Caf/Ry)-releasable and inositol-1,4,5-trisphosphate (InsP3)-releasable Ca2+ stores in the sarcoplasmic reticulum (SR) of smooth muscles are at least partially distinct. We directly visualized SR stores in primary-cultured rat mesenteric artery myocytes with high-resolution digital imaging and the low-affinity Ca2, indicator, Furaptra (Kd = 75.6 microM). The SR appears to be a continuous tubular network. Nevertheless, SR Ca2+ stores are organized into small, separate, functionally independent compartments. Cyclopiazonic acid (CPA; inhibits SR (Ca2+ pump) and Caf (or Ry) release Ca2+ from different, spatially distinct compartments. Similar heterogeneity is seen with serotonin (acts via InsP3), which unloads only the CPA-sensitive compartments. Some of the SR ('junctional' SR; jSR) lies within 12-15 nm of the plasmalemma (PL). The jSR, the overlying PL microdomains, and the intervening, tiny volume of cytosol form junctional complexes ('PLasmERosomes'). Na+ pumps with high-ouabain-affinity alpha2 or alpha3 subunits, Na+/Ca2+ exchangers, and store-operated channels are confined to these PL microdomains, whereas Na+ pumps with low-ouabain-affinity alpha1 subunits and plasma membrane Ca2+ pumps are uniformly distributed. As a result of this organization, low-dose ouabain can selectively modulate Na+ and Ca2+ concentrations in the PLasmERosomes and jSR Ca2+ stores, and can thereby regulate Ca2+ signalling.
Estimating the State of AC Power Systems using Semidefinite Programming (2011)

This paper has been withdrawn by the authors
Piezoelectricity of PVDF/PUE, PVDF/PMMA and PVDF/PMMA+BaTiO/sub 3/ laminates (1992)

Preparation of piezoelectric laminates by using PVDF polymer film (a), polyester urethane elastomer film (b), PMMA film (c), and (PMMA+BaTiO/sub 3/) composite film (d) is proposed. Three-layered-structure systems of (aba), (aca), and (ada) have been made and conventional electrets based on these laminates have been prepared. The modification of internal layers in the systems leads to a change of their dielectric properties and also the mechanical parameters which determine the piezoelectricity. The origins of piezoelectricity in these systems have been considered on the basis of TSD thermograms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Peer Reviewed: Environmental Technologies at the Nanoscale (2003)

ADVERTISEMENT RETURN TO ISSUEPREVFeaturesNEXTPeer Reviewed: Environmental Technologies at the NanoscaleNanotechnology could substantially enhance environmental quality and sustainability through pollution prevention, treatment, and remediation.Tina Masciangioli and Wei-Xian ZhangCite this: Environ. Sci. Technol. 2003, 37, 5, 102A–108APublication Date (Web):March 1, 2003Publication History Published online1 March 2003Published inissue 1 March 2003https://pubs.acs.org/doi/10.1021/es0323998https://doi.org/10.1021/es0323998newsACS Publications. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views9537Altmetric-Citations459LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (267 KB) Get e-Alertsclose SUBJECTS:Nanoscale Get e-Alerts
Influence of the ELISA format and the hapten-enzyme conjugate on the sensitivity of an immunoassay for S-triazine herbicides using monoclonal antibodies (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of the ELISA format and the hapten-enzyme conjugate on the sensitivity of an immunoassay for S-triazine herbicides using monoclonal antibodiesPeter. Schneider and Bruce D. HammockCite this: J. Agric. Food Chem. 1992, 40, 3, 525–530Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/jf00015a033https://doi.org/10.1021/jf00015a033research-articleACS PublicationsRequest reuse permissionsArticle Views395Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Error-resilient video coding using multiple description motion compensation (2002)

A new approach for multiple description video coding is proposed. It employs a second-order predictor for motion-compensation, which predicts a current frame from two previously coded frames. The coder generates two descriptions, containing the coded even and odd frames, respectively. When only a single description (say, that containing even frames) is received, the decoder can only use previous even frames for prediction. The mismatch between the predicted frames at the encoder and decoder is explicitly coded to avoid error propagation in the ideal MD channels, where a description is either received intact or lost completely. By using the second-order predictor and coding the mismatch signal, one can also suppress error propagation in packet lossy networks where packets in either description can be lost. The predictor and the mismatch signal quantizer can be varied to achieve a wide range of tradeoffs between coding efficiency and error resilience.
Silicon Nitride Coated Silicon Thin Films As Anodes for Li-Ion Batteries (2015)

When using silicon in anodes for Li-ion batteries, there is a tradeoff between using small silicon structures to avoid cracking and having small surface area to reduce electrolyte degradation due to an unstable Solid Electrolyte Interface (SEI). To facilitate the growth of a stable and thin SEI, we propose to coat silicon with a thin layer of silicon nitride. Silicon nitride by itself has been determined to function as a conversion electrode material, forming lithium nitride and elemental silicon during the initial lithiation. Using a thin film model system, we demonstrate the effect of using nitride coatings with different stoichiometry on the cyclability and high rate capacity of the electrodes. The results show that a nitride coating has a positive effect on both the cycling stability and high rate performance.
Thermostable Cellulases / Xylanases From Thermophilic and Hyperthermophilic Microorganisms: Current Perspective (2021)

The bioconversion of lignocellulose into monosaccharides is critical for ensuring the continual manufacturing of biofuels and value-added bioproducts. Enzymatic degradation, which has a high yield, low energy consumption, and enhanced selectivity, could be the most efficient and environmentally friendly technique for converting complex lignocellulose polymers to fermentable monosaccharides, and it is expected to make cellulases and xylanases the most demanded industrial enzymes. The widespread nature of thermophilic microorganisms allows them to proliferate on a variety of substrates and release substantial quantities of cellulases and xylanases, which makes them a great source of thermostable enzymes. The most significant breakthrough of lignocellulolytic enzymes lies in lignocellulose-deconstruction by enzymatic depolymerization of holocellulose into simple monosaccharides. However, commercially valuable thermostable cellulases and xylanases are challenging to produce in high enough quantities. Thus, the present review aims at giving an overview of the most recent thermostable cellulases and xylanases isolated from thermophilic and hyperthermophilic microbes. The emphasis is on recent advancements in manufacturing these enzymes in other mesophilic host and enhancement of catalytic activity as well as thermostability of thermophilic cellulases and xylanases, using genetic engineering as a promising and efficient technology for its economic production. Additionally, the biotechnological applications of thermostable cellulases and xylanases of thermophiles were also discussed.
Dispersion compensation by active predistorted signal synthesis (1985)

Techniques for the synthesis of an optical signal predistorted to compensate for fiber dispersion are discussed theoretically. A scheme for very high bit rate (>10 Gbit/s) time-division-multiplexed transmission is proposed which neither requires extremely short pulse sources nor suffers from their inherent dispersion limitations. The rudimentary aspects of the techniques have been verified experimentally by demonstrating both enhanced and degraded transmission of a 4-GHz modulated signal at 1.55 μm over 10-30 km of optical fiber.
A Reputation Mechanism for Virtual Reality - Five-Sense Oriented Feedback Provision and Subjectivity Alignment (2011)

In this paper, we propose a reputation mechanism for virtual marketplaces. The proposed approach is based on five-sense oriented feedback provision with the support of existing virtual reality technologies. We have conducted user studies to analyse users' attitude towards this new approach. These studies reveal that users prefer virtual marketplaces with our proposed reputation mechanism over that with traditional reputation mechanisms, and that our mechanism can effectively ensure user's trust in the virtual marketplaces and simultaneously promote user's trust in other users. Our approach is based on feedback from other users. Feedback from users could be very subjective and misleading for other users. Hence, we propose a novel mechanism to align subjective user feedback before reputation computations in virtual marketplaces. Results of our experiment demonstrate that with our feedback alignment approach, buyers can more accurately model sellers' reputation.
Experiences in local networking at USF (2002)

Some of the experiences in networking at the University of South Florida (USF) College of Engineering are described. The LAN selection process and the wiring requirements are outlined. Two networks, the transcendental operating system (TOPS) and the 3Com Ethernet, are reviewed for implementation in this college environment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Alkylation of Porous Silicon by Direct Reaction with Alkenes and Alkynes (1998)

The hydrogen-terminated surface of porous silicon (PS) is sufficiently reactive for the uncatalyzed hydrosilation of alkenes and alkynes. These modifications produce dramatic changes to both the physical and chemical properties of the PS.
Generation of 8 fs, 125 mJ Pulses Through Optical Parametric Chirped Pulse Amplification (2009)

We report generation of three-cycle, 8 fs, 125 mJ optical pulses in a noncollinear optical parametric chirped-pulse amplifier (NOPCPA). These 16 TW laser pulses are compressed to within 6% of their Fourier limit.
Bisphenol A imprinted polymer adsorbents with selective recognition and binding characteristics (2005)

Imprinted copolymers, which highly recognized and bound bisphenol A (Bis A), were synthesized by using covalent imprinting technique. Bisphenol A dimethacrylate (BADM) was used as a template monomer in the copolymerization with a crosslinkable monomer of divinyl benzene (DVB), ethylene glycol dimethacrylate (EGDM) or N,N’-methylenebisacrylamide (MBAA). The resultant copolymer was hydrolyzed in acidic or basic condition. It was found that the Bis A imprinted copolymers of EGDM and MBAA had no selectivity to Bis A, because the crosslinker dissociated by the hydrolysis reaction and thus comprehensive imprinted sites were not formed. On the other hand, imprinted copolymer of DVB showed excellent selectivity to differentiate Bis A from bisphenol E and bisphenol F (Bis F). Characterization of the copolymers suggested that the DVB copolymer had resistance to the acid and alkali conditions. Effect of recognition by the Bis F imprinted polymer was also compared with that of the Bis A imprinted polymer, when DVB and bisphenol F dimethacrylate were copolymerized. The Bis F imprinted copolymer was able to recognize Bis F in ethanol solution, however showed higher binding capacity for both Bis A and Bis F in water solution without recognition. Therefore, hydrophobic interaction between Bis A and the imprinted site enhanced the binding capacity with high selectively for the BADM-co-DVB imprinted copolymer.
Climatic turn in migration studies? Geographical perspectives on the relationship between climate and migration (2016)

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Bacteriological quality of organically grown leaf lettuce in Norway (2005)

These results suggest that organically grown lettuce may be contaminated with E. coli and L. monocytogenes during cultivation.