gebhart/patrepeval huggingface dataset:
Sensitivity Analysis of a Neural Network based Avionic System by Simulated Fault and Noise Injection (2018)

The application of virtual sensor is widely discussed in literature as a cost effective solution compared to classical physical architectures. RAMS (Reliability, Availability, Maintainability and Safety) performance of the entire avionic system seem to be greatly improved using analytical redundancy. However, commercial applications are still uncommon. A complete analysis of the behavior of these models must be conducted before implementing them as an effective alternative for aircraft sensors. In this paper, a virtual sensor based on neural network called Smart-ADAHRS (Smart Air Data, Attitude and Heading Reference System) is analyzed through simulation. The model simulates realistic input signals of typical inertial and air data MEMS (Micro Electro-Mechanical Systems) sensors. A procedure to define the background noise model is applied and two different cases are shown. The first considers only the sensor noise whereas the latter uses the same procedure with the operative flight noise. Flight tests have been conducted to measure the disturbances on the inertial and air data sensors. Comparison of the Power Spectral Density function is carried out between operative and background noise. A model for GNSS (Global Navigation Satellite System) receiver, complete with constellation simulator and atmospheric delay evaluation, is also implemented. Eventually, a simple multi-sensor data fusion technique is modeled. Results show good robustness of the Smart-ADAHRS to the sensor faults and a marginal sensitivity to the temperature-related faults. Solution for this kind of degradation is indicated at the end of the paper. Influences of noise on input signals is also discussed.
Quantum Cascade Raman Injection Laser for Mid/Far-Infrared Generation (2005)

We report theory and experimental realization of the first Raman injection laser. It integrates quantum cascade active regions with Raman-active sections where Stokes component of the fundamental laser frequency is generated via intersubband Raman scattering.
Synthesis and photoelectrochemical properties of a fullerene–azothiophene dyad (1999)

In this paper we describe the synthesis, electrochemistry and photophysical behavior of a fullerene-based donor–acceptor dyad (2) in which the donor unit is an azothiophene dye. Dyad 2, prepared in one step starting from C60, commercially available N-methylglycine and thienylazobenzeneamine 1, can be selectively excited in the visible region where the dye has an absorption maximum at 567 nm. Implementation of electrochemical and photophysical data reveals that both intramolecular energy- and electron-transfer are thermodynamically feasible processes. Steady-state luminescence of dyad 2 in CH2Cl2 shows a quenching of the dye singlet excited state (1dye*) and evidence of the fullerene singlet excited state (1C60*) emission. Flash-photolytic experiments, on the other hand, exhibit characteristic differential absorption changes attributed to the C60·––dye·+ charge-separated state. Interestingly, it has been estimated that the energy difference between 1C60* and the charge separated state is very small, leading to the hypothesis that a rapid exchange between the two states occurs. Sensitization of TiO2 with dyad 2 and model compound 3 is also reported and discussed.
Individually Tailored Internet-Based Cognitive-Behavioral Therapy for Daily Functioning in Patients with Parkinson’s Disease: A Randomized Controlled Trial (2020)

ClinicalTrials.gov NCT02627885.
Using a Temporary Silicon Connection in Stereoselective Allylation with Allylsilanes: Application to the Synthesis of Stereodefined 1,2,4‐Triols. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Synthesis of novel 2‐(2‐methylsulfonyl‐1‐methyl‐1H‐imidazol‐5‐yl)‐5‐(alkylsulfonyl)‐1,3,4‐thiadiazoles (2010)

Abstract Starting from 5‐hydroxymethyl‐2‐mercapto‐1‐methyl‐1 H ‐imidazole (1), a series of 2‐(1‐methyl‐2‐methylsulfonyl‐1 H ‐imidazol‐5‐yl)‐5‐alkylthio and 5‐alkylsulfonyl‐1,3,4‐thiadiazole derivatives ( 9a , 9b , 9c , 9d and 10a , 10b , 10c , 10d ) were prepared as potential antimicrobial agents. The structure of the obtained compounds was confirmed by NMR, IR, Mass spectroscopy, and elemental analysis. J. Heterocyclic Chem., (2010)
Prion Replication Occurs in Endogenous Adult Neural Stem Cells and Alters Their Neuronal Fate: Involvement of Endogenous Neural Stem Cells in Prion Diseases (2013)

Prion diseases are irreversible progressive neurodegenerative diseases, leading to severe incapacity and death. They are characterized in the brain by prion amyloid deposits, vacuolisation, astrocytosis, neuronal degeneration, and by cognitive, behavioural and physical impairments. There is no treatment for these disorders and stem cell therapy therefore represents an interesting new approach. Gains could not only result from the cell transplantation, but also from the stimulation of endogenous neural stem cells (NSC) or by the combination of both approaches. However, the development of such strategies requires a detailed knowledge of the pathology, particularly concerning the status of the adult neurogenesis and endogenous NSC during the development of the disease. During the past decade, several studies have consistently shown that NSC reside in the adult mammalian central nervous system (CNS) and that adult neurogenesis occurs throughout the adulthood in the subventricular zone of the lateral ventricle or the Dentate Gyrus of the hippocampus. Adult NSC are believed to constitute a reservoir for neuronal replacement during normal cell turnover or after brain injury. However, the activation of this system does not fully compensate the neuronal loss that occurs during neurodegenerative diseases and could even contribute to the disease progression. We investigated here the status of these cells during the development of prion disorders. We were able to show that NSC accumulate and replicate prions. Importantly, this resulted in the alteration of their neuronal fate which then represents a new pathologic event that might underlie the rapid progression of the disease.
Préparation de la poly-DL-phénylalanine en hélice par polymérisation de la DL-benzyl-4 oxazolidine dione-2-5 (1963)

Nous avons étudié la polymérisation de la DL-benzyl-4 oxazolidine dione-2,5 pour préparer des échantillons peu polydisperses de poly-DL-phenylalanine en hélice ayant des masses moléculaires aussi variées que possible. Les meilleurs résultats ont été obtenus en initiant la polymérisation par le méthanolate de sodium dans le chloroforme; la masse moléculaire des produits est limitée à 120 000 dans les conditions expérimentales décrites ci-dessous. Le même initiateur dans le dioxane permet d'atteindre des masses moléculaires un peu plus élevées mais il faut éliminer un taux variable de polymères dont la configuration hélicoïdale est irrégulière.
Iloprost attenuates hyperoxia-mediated impairment of lung development in newborn mice (2018)

Cyclooxygenase-2 (COX-2/PTGS2) mediates hyperoxia-induced impairment of lung development in newborn animals and is increased in the lungs of human infants with bronchopulmonary dysplasia (BPD). COX-2 catalyzes the production of cytoprotective prostaglandins, such as prostacyclin (PGI<sub>2</sub>), as well as proinflammatory mediators, such as thromboxane A2. Our objective was to determine whether iloprost, a synthetic analog of PGI<sub>2</sub>, would attenuate hyperoxia effects in the newborn mouse lung. To test this hypothesis, newborn C57BL/6 mice along with their dams were exposed to normoxia (21% O<sub>2</sub>) or hyperoxia (85% O<sub>2</sub>) from 4 to 14 days of age in combination with daily intraperitoneal injections of either iloprost 200 µg·kg<sup>-1</sup>·day<sup>-1</sup>, nimesulide (selective COX-2 antagonist) 100 mg·kg<sup>-1</sup>·day<sup>-1</sup>, or vehicle. Alveolar development was estimated by radial alveolar counts and mean linear intercepts. Lung function was determined on a flexiVent, and multiple cytokines and myeloperoxidase (MPO) were quantitated in lung homogenates. Lung vascular and microvascular morphometry was performed, and right ventricle/left ventricle ratios were determined. We determined that iloprost (but not nimesulide) administration attenuated hyperoxia-induced inhibition of alveolar development and microvascular density in newborn mice. Iloprost and nimesulide both attenuated hyperoxia-induced, increased lung resistance but did not improve lung compliance that was reduced by hyperoxia. Iloprost and nimesulide reduced hyperoxia-induced increases in MPO and some cytokines (IL-1β and TNF-α) but not others (IL-6 and KC/Gro). There were no changes in pulmonary arterial wall thickness or right ventricle/left ventricle ratios. We conclude that iloprost improves lung development and reduces lung inflammation in a newborn mouse model of BPD.
Cardiac surgery considerations and lessons learned during the COVID‐19 pandemic (2020)

The COVID-19 pandemic has transformed cardiac surgical practices. Limitations in intensive care resources and personal protective equipment have required many practices throughout the globe to pause elective operations and now slowly resume operations. However, much of cardiac surgery is not elective and patients continue to require surgery on an urgent or emergent basis during the pandemic. This continued need for providing surgical services has introduced several unique considerations ranging from how to prioritize surgery, how to ensure safety for cardiac surgical teams, and how best to resume elective operations to ensure the safety of patients. Additionally, the COVID-19 pandemic has required a careful analysis of how best to carry out heart transplantation, extra-corporeal membrane oxygenation, and congenital heart surgery. In this review, we present the many areas of multidisciplinary consideration, and the lessons learned that have allowed us to carry out cardiac surgery with excellence during the COVID-19 pandemic. As various states experience plateaus, declines, and rises in COVID-19 cases, these considerations are particularly important for cardiac surgical programs throughout the globe.
ChemInform Abstract: Synthesis of Pharmaceutically Active Compounds Containing a Disubstituted Piperidine Framework. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Phase I/II study of carboplatin and oral etoposide with granulocyte-colony stimulating factor in advanced nonsmall cell lung cancer (1995)

Background. A combination of carboplatin (CBDCA) and oral etoposide is better tolerated than, and as effective as, more aggressive chemotherapy regimens in patients with advanced nonsmall cell lung cancer (NSCLC). A Phase I/II study was conducted to determine whether the addition of the granulocyte-colony stimulating factor (G-CSF) allows the administration of higher doses of CBCDA. Methods. The starting dose of CBDCA was 300 mg/m2 on day 1 every 28 days, in combination with a fixed dose of oral etoposide 50 mg/m2/day days 1-21. G-CSF (5 m̈g/kg/day subcutaneously) was administered from day 7 until postnadir neutrophil count of more than 10,000/mm3, and from day 25 through day 28. Results. From March 1991 to November 1993, 39 previously untreated patients with NSCLC (18 Stage IIIb and 21 Stage IV) entered this trial. Overall eight patients experienced dose-limiting toxicity in the first two courses. Five of them were older than 70 years. Age, CBDCA dose, CBDCA area under the curve (AUC), and performance status were correlated with severe neutropenia and thrombocytopenia, but carboplatin AUC was the only independent variable predictive of severity of both at multiple regression analysis. Thrombocytopenia was the major dose-limiting toxicity in this study. The maximum tolerated CBDCA dose and AUC were 600 mg/m2 and 8 respectively. No treatment-related death occurred. There was 1 (2.5%) complete response and 14 (36%) partial responses (overall response rate of 38.5%). AUC was more predictive of response achievement than carboplatin dose. Higher carboplatin dose and AUC were also associated with longer survival by univariate analysis, but by Cox regression analysis age was the only parameter independently predictive of survival. Conclusion. The administration of G-CSF permits safe escalation of CBDCA dose and AUC up to 600 mg/m2 and 8 respectively, in combination with a fixed dose of oral etoposide. Age older than 70 years represents a major obstacle to dose escalation. The increase of the body exposure to carboplatin seems to be associated with a better outcome. The determination of CBDCA AUC permits a better prediction of myelotoxicity and response rate. Cancer 1995;75:1568-77.
Thietanes. IV. Rearrangement of 2,4-diphenylthietane oxides (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThietanes. IV. Rearrangement of 2,4-diphenylthietane oxidesRaymond M. Dodson, Philip D. Hammen, and Jane Y. FanCite this: J. Org. Chem. 1971, 36, 18, 2703–2708Publication Date (Print):September 1, 1971Publication History Published online1 May 2002Published inissue 1 September 1971https://pubs.acs.org/doi/10.1021/jo00817a028https://doi.org/10.1021/jo00817a028research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prostaglandins (1965)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Off-Label Thrombolysis Is Not Associated With Poor Outcome in Patients With Stroke (2010)

Off-license thrombolysis was not associated with poorer clinical outcome, except for age >80 years, nor with increased rates of symptomatic intracerebral hemorrhage. The current extensive list of contraindications should be re-evaluated when data from ongoing randomized trials and observational studies become available.
Chromosome 8 alterations accompany tumorigenesis in renin-SV40 T antigen transgenic mice. (1994)

s.c. and abdominal tumors from interspecific hybrid, transgenic mice containing the SV40 early region linked to a renin enhancer/promoter were analyzed for loss of heterozygosity to identify chromosomal regions involved in tumorigenesis. A very high frequency of loss of heterozygosity/partial loss of heterozygosity or allelic imbalance involving the distal regions of chromosome 8 was observed in the s.c. tumors (76%) with frequent amplification (3-6 times) of the corresponding proximal regions including Junb, suggesting that chromosome 8 breakage and amplification promotes tumorigenesis in these mice.
Non-Contact Blood Pressure Measurement Scheme Using Doppler Radar (2019)

A continuous cuffless non-contact blood pressure (BP) measurement scheme using Doppler radar is proposed. This non-contact BP estimation scheme uses the periods in which the heart beats and periods in which the heart contracts. These periods are obtained using Doppler radar signals. Diastolic BP (DBP) was estimated using the period in which the heart contracts. Pulse pressure (PP) was estimated using one period in which the heart beats and one period in which the heart contracts. Systolic BP (SBP) was obtained by the sum of the estimated DBP and PP. The correlation of the estimated BP and the BP acquired by the BP monitor was calculated. The correlation coefficients were 0.79 for SBP, 0.88 for DBP, and 0.81 for PP. The BP was successfully measured in a contactless manner.
A study of copper ions in silver-halide photochromic glasses (1977)

Measurements of optical absorption, kinetics, electron-spin resonance, and flash photolysis, as well as x-ray fluorescence and wet-chemical analysis, have been applied to a series of silver-halide photochromic glasses having precisely controlled variations in silver and copper concentrations as well as in the size of the precipitated silver-halide microphases. These combined experimental data have enabled us to clarify the manner in which copper enters the microphases and the mechanisms whereby it affects their photochromic properties. Most notably, we have succeeded in determining the site and valence-state distribution of copper ions, produced by the separation of the microphases. We have demonstrated, for example, that copper enters the silver-halide phase only as cuprous ions, which then act as the dominant hole traps in the photochromic darkening process. Optical absorption of these cuprous ions in the silver-halide phase was also found to make a major contribution to the absorption edge observed in the undarkened photochromic glasses. The increase of thermal fade rate with increasing copper content is discussed in light of these new experimental results.
Dual-Level Compressed Aggregation: Recovering Fields of Physical Quantities from Incomplete Sensory Data (2011)

Although wireless sensor networks (WSNs) are powerful in monitoring physical events, the data collected from a WSN are almost always incomplete if the surveyed physical event spreads over a wide area. The reason for this incompleteness is twofold: i) insufficient network coverage and ii) data aggregation for energy saving. Whereas the existing recovery schemes only tackle the second aspect, we develop Dual-lEvel Compressed Aggregation (DECA) as a novel framework to address both aspects. Specifically, DECA allows a high fidelity recovery of a widespread event, under the situations that the WSN only sparsely covers the event area and that an in-network data aggregation is applied for traffic reduction. Exploiting both the low-rank nature of real-world events and the redundancy in sensory data, DECA combines matrix completion with a fine-tuned compressed sensing technique to conduct a dual-level reconstruction process. We demonstrate that DECA can recover a widespread event with less than 5% of the data, with respect to the dimension of the event, being collected. Performance evaluation based on both synthetic and real data sets confirms the recovery fidelity and energy efficiency of our DECA framework.
Lithiophosphinoferrocenes. A route to polyphosphines and ring-substituted ferrocenophanes (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLithiophosphinoferrocenes. A route to polyphosphines and ring-substituted ferrocenophanesIan R. Butler and William R. CullenCite this: Organometallics 1986, 5, 12, 2537–2542Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/om00143a023https://doi.org/10.1021/om00143a023research-articleACS PublicationsRequest reuse permissionsArticle Views958Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multi-Turn Response Selection for Chatbots with Deep Attention Matching Network (2018)

Xiangyang Zhou, Lu Li, Daxiang Dong, Yi Liu, Ying Chen, Wayne Xin Zhao, Dianhai Yu, Hua Wu. Proceedings of the 56th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers). 2018.
Porcine lung mesenchymal stromal cells possess differentiation and immunoregulatory properties (2015)

Here, we demonstrate that MSCs can be isolated from porcine lung and that these cells, similar to human lung MSCs, possess in vitro proliferation, differentiation and immunomodulatory functions. Thus, these cells may serve as a model system to evaluate the contribution of lung MSCs in modulating the immune response, interactions with resident epithelial cells and tissue repair in a pig model of human lung diseases.
<title>Bulk micromachining for sensors and actuators</title> (2000)

Silicon bulk micromachining which is based on a silicon etching and a glass- silicon anodic bonding plays important roles to make micro sensors and micro actuators. Three dimensional microfabrication of other functional materials as piezoelectric materials are also important to develop high performance microactuators, micro energy source and so on. Vacuum sealing is required to prevent a viscous dumping for packages micromechanical sensors. Extremely small structures as microprobe are required for high resolution, high sensitivity and quick response. As sophisticated microsystems which are made of many sensors, circuits and actuators are required for example for maintenance tools used in a narrow space. Developments for those required will be described.