gebhart/patrepeval huggingface dataset:
Purification and Characterization of a Nonspecific Lipid Transfer Protein 1 (nsLTP1) from Ajwain (Trachyspermum ammi) Seeds (2019)

Ajwain (Trachyspermum ammi) belongs to the family Umbelliferae, is commonly used in traditional, and folk medicine due to its carminative, stimulant, antiseptic, diuretic, antihypertensive, and hepatoprotective activities. Non-specific lipid transfer proteins (nsLTPs) reported from various plants are known to be involved in transferring lipids between membranes and in plants defense response. Here, we describe the complete primary structure of a monomeric non-specific lipid transfer protein 1 (nsLTP1), with molecular weight of 9.66 kDa, from ajwain seeds. The nsLTP1 has been purified by combination of chromatographic techniques, and further characterized by mass spectrometry, and Edman degradation. The ajwain nsLTP1 is comprised of 91 amino acids, with eight conserved cysteine residues. The amino acid sequence based predicted three dimensional (3D) structure is composed of four α-helices stabilized by four disulfide bonds, and a long C-terminal tail. The predicted model was verified by using different computational tools; i.e. ERRAT, verify 3D web server, and PROCHECK. The docking of ajwain nsLTP1 with ligands; myristic acid (MYR), and oleic acid (OLE) was performed, and molecular dynamics (MD) simulation was used to validate the docking results. The findings suggested that amino acids; Leu11, Leu12, Ala55, Ala56, Val15, Tyr59, and Leu62 are pivotal for the binding of lipid molecules with ajwain nsLTP1.
Повышение малоцикловой усталостной прочности сталей электростимулированием (1998)

The velocity of ultrasound distribution V in metals and alloys is a structurally sensitive characteristics and can catch the changes, taking place in materials during a deformation and heat treatment. This makes it perspective for diagnostics of materials in time of fatigue loading. The dependence of V on a number of cycles of loading consists of three logical stages with different rate of quantity changes. We used 40, 40H, 70XGSA, X18N10T, 38X2MUA, 08G2S steels. The timely discovery of beginning the critical stage of fatigue on fall of dependence V(n) was used in work for recovery of articles resource on account of external energy action by powerful short one-pole current impulses, created by specially produced of thruster generator.
Inhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein. (1994)

Two flavones, 4',5,7-trihydroxy-6-methoxy flavone (dinatin) and 4',5-dihydroxy-6, 7-dimethoxy flavone (skrofulein), were extracted from Artemisia herba alba L. Dinatin and skrofulein inhibited the binding of [methyl-3H]diazepam to rat brain membranes in vitro with IC50 of 1.3 and 23 mumol.L-1, respectively. The GABA-ratios (the ratio of IC50 values in the absence/presence of GABA in the binding assay) were 1.1 and 1.2 for dinatin and skrofulein, respectively. Both flavones induced a slight increase in [35S] TBPS binding. The data suggest that the flavones are antagonists or partial agonists of benzodiazepine receptors.
Spontaneous activation of NADPH oxidase in a cell-free system: unexpected multiple effects of magnesium ion concentrations (1999)

The role of magnesium ions in the activation of NADPH oxidase has been investigated using flavocytochrome b-245 and either neutrophil cytosol or mixtures of recombinant p40phox, p47phox, p67phox and Rac2. Purified flavocytochrome b-245 is highly active (turnover number 120-150 mol of O2(-)/s per mol of cytochrome haem) in the absence of Mg2+, in marked contrast to neutrophil membranes or detergent-solubilized membranes, which have an absolute requirement for Mg2+ for NADPH oxidase activity. It was also found that Mg2+ affected the anionic amphiphile requirement for oxidase activation, and this was dependent on whether neutrophil cytosol or mixtures of recombinant cytosolic proteins were used in the assay. Unexpectedly we found that, using purified flavocytochrome b-245 and recombinant cytosolic proteins, NADPH oxidase undergoes spontaneous activation in the absence of anionic amphiphiles under Mg2+-free conditions. The results suggest that Mg2+ ions play an important role in NADPH oxidase function, perhaps stabilizing the 260 kDa complex of cytosolic phox proteins or the regulation of a guanine nucleotide-binding protein. We provide evidence that if the latter explanation is correct, the identity of the guanine nucleotide-binding protein is unlikely to be Rap1a.
Reliability of Destructive Leakage Detection Methods for Semirigid Retort Packages (1996)

Three different destructive testing methods for package integrity (biotesting, dye penetration and electrical conductance) were compared with each other using intact and leaking retort packages. In biotesting, both vegetative cells of Enterobacter aerogenes and spores of Bacillus subtilis were used as test microbes. The biotest results did not significantly differ from each other, most packages with a 50 pm channel leak through the seal area were contaminated. Biotesting with E. aerogenes was regarded as a more favourable method than testing with spores of B. subtilis since it was easier to perform and gas formation in the packages was a simple indicator for product contamination. The electrolytic test was able to discover most of the leaking packages more reliably than the biotests and the dye penetration test. The dye test had similar sensitivity in identifying leaks to that of the biotests. In conclusion, the microbial integrity of packages should not be estimated only by biotests, even if they are generally regarded as the most severe package integrity test methods.
Det sidste hvilested. Om tilhørsforhold og identitetsdannelse blandt muslimer i Danmark (2015)

Et stigende antal muslimske indvandrere og flygtninge vælger i dag at blive begravet i Danmark. Artiklen analyserer deres valg af sidste hvilested på henholdsvis en traditionel og en kommunal kirkegård samt på Danmarks eneste muslimske begravelsesplads i Brøndby, og indkredser derigennem en række markører, der kan udsige noget om identitetsdannelse og tilhørsforhold til den danske majoritetskultur. Analysen indkredser to tendenser i muslimsk begravelseskultur, henholdsvis en sakraliserings- og sekulariseringstendens, som kommer til udtryk der, hvor muslimer har et reelt valg mellem flere begravelsespladser. Det konkluderes, at muslimer i Danmark i al stilhed er i færd med en territorialiseringsproces, der foregår helt uden den turbulens, som ellers ofte præger den offentlige debat om muslimske indvandrere.
Aortic root geometry and stentless porcine valve competence. (1999)

The goal of this study was to characterize medium-term changes in aortic root geometry after stentless aortic valve replacement, the relationship between aortic sinotubular junction and the competence of stentless valves. A total of 205 consecutive patients (mean age 73+/-6 years; 120 men, 85 women) received a Freestyle stentless porcine aortic valve and were studied prospectively by echocardiography from 1 week to 5 years. Internal diameters of outflow tract, annulus, sinus, sinotubular junction, and ascending aortic root were measured at early ejection and indexed to stentless valve size. The degree of stentless valve regurgitation was semiquantified by color Doppler echocardiography. A total of 701 echocardiographic studies were obtained and analyzed; 73% showed a fully competent stentless valve (nAR) and 13% and 14%, respectively, showed a trivial (tAR) or mild (mAR) regurgitation. Sinotubular junction of tAR or mAR was significantly greater than that of nAR (111+/-1.9, 117+/-2.2 vs. 104+/-1.0, percentage of valve size, P<.001). A preoperative diagnosis of aortic regurgitation (110+/-2.6 vs. 104+/-1.0, percentage of valve size, P<.001) and 4 to 5-year follow-up time (116+/-2.2 vs. 107+/-2.9, percentage of valve size, P = .023) were associated with a greater sinotubular junction, although the incidence and mean grade of stentless valve regurgitation did not change significantly during the follow-up period. Up to medium-term follow-up evaluation, the incidence of moderate stentless aortic regurgitation is less than 5%. The nature of valve disease and age-related increase in sinotubular junction may have reduced the cusp coaptation area of the stentless valve and may predict the presence of a trivial or mild regurgitation. Understanding the interrelations between the stentless valve and remodeling of the aging aorta has important implications for both surgical technique and long-term follow-up outcome.
4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere: Synthesis and Biological Evaluation (1994)

4-Deacetyltaxol and 10-acetyl-4-deacetyltaxotere were synthesized for the first time from 7-(triethylsilyl)-4-deacetylbaccatin III. These analogs were found to be inactive in the microtubule assembly assay.
Can Quality Revitalize the Alaskan Salmon Industry? (2004)

Declining salmon prices, due primarily to expansion of farmed salmon production, have reduced revenues for Alaska's wild salmon fisheries by roughly 62 percent over the past 10 years. One possibility for reversing this trend is to differentiate wild and farmed salmon in consumer markets through quality improvements and marketing. We use a simple conceptual model to highlight the challenges that Alaska's wild salmon industry must overcome before the industry is likely to see significant revenue gains from increased quality. Our tentative conclusion is that product differentiation could increase profits for wild salmon. However, implementation may require significant departures from traditional production and management practices and possibly an amendment to the Alaska state constitution.
Apoptosis and Necrosis Occur in Separate Neuronal Populations in Hippocampus and Cerebellum after Ischemia and Are Associated with Differential Alterations in Metabotropic Glutamate Receptor Signaling Pathways (2000)

It was evaluated whether postischemic neurodegeneration is apoptosis and occurs with alterations in phosphoinositide-linked metabotropic glutamate receptors (mGluRs) and their associated signaling pathways. A dog model of transient global incomplete cerebral ischemia was used. The CA1 pyramidal cells and cerebellar Purkinje cells underwent progressive delayed degeneration. By in situ end-labeling of DNA, death of CA1 and Purkinje cells was greater at 7 days than 1 day after ischemia, whereas death of granule neurons in dentate gyrus and cerebellar cortex was greater at 1 than at 7 days. Ultrastructurally, degenerating CA1 pyramidal neurons and cerebellar Purkinje cells were necrotic; in contrast, degenerating granule neurons were apoptotic. In agarose gels of regional DNA extracts, random DNA fragmentation coexisted with internucleosomal fragmentation. By immunoblotting of regional homogenates, mGluR1alpha, mGluR5, phospholipase Cbeta (PLCbeta), and Galphaq/11 protein levels in hippocampus at 1 and 7 days after ischemia were similar to control levels, but in cerebellar cortex, mGluR1alpha and mGluR5 were decreased but PLCbeta was increased. By immunocytochemistry, mGluR and PLCbeta immunoreactivity dissipated in CA1 and cerebellar Purkinje cell/ molecular layers, whereas immunoreactivities for these proteins were enhanced in granule neurons. It was concluded that neuronal death after global ischemia exists as two distinct, temporally overlapping forms in hippocampus and cerebellum: necrosis of pyramidal neurons and Purkinje cells and apoptosis of granule neurons. Neuronal necrosis is associated with a loss of phosphoinositide-linked mGluR transduction proteins, whereas neuronal apoptosis occurs with increased mGluR signaling.
How do programs become more concurrent (2011)

In the multi-core era, programmers need to resort to parallelism if they want to improve program performance. Thus, a major maintenance task will be to make sequential programs more concurrent. Must concurrency be designed into a program, or can it be retrofitted later? What are the most common transformations to retrofit concurrency into sequential programs? Are these transformations random, or do they belong to certain categories? How can we automate these transformations?
The E2E Dataset: New Challenges For End-to-End Generation (2017)

This paper describes the E2E data, a new dataset for training end-to-end, datadriven natural language generation systems in the restaurant domain, which is ten times bigger than existing, frequently used datasets in this area. The E2E dataset poses new challenges: (1) its human reference texts show more lexical richness and syntactic variation, including discourse phenomena; (2) generating from this set requires content selection. As such, learning from this dataset promises more natural, varied and less template-like system utterances. We also establish a baseline on this dataset, which illustrates some of the difficulties associated with this data.
ChemInform Abstract: Synthesis and Antimicrobial Activity of N10‐ Arylidenehydrazidophenothiazine and Their 4‐Thiazolidinones and 2‐ Azetidinones. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Estimation of Filling and Afterload Conditions by Pump Intrinsic Parameters in a Pulsatile Total Artificial Heart (2015)

A physiological control algorithm is being developed to ensure an optimal physiological interaction between the ReinHeart total artificial heart (TAH) and the circulatory system. A key factor for that is the long-term, accurate determination of the hemodynamic state of the cardiovascular system. This study presents a method to determine estimation models for predicting hemodynamic parameters (pump chamber filling and afterload) from both left and right cardiovascular circulations. The estimation models are based on linear regression models that correlate filling and afterload values with pump intrinsic parameters derived from measured values of motor current and piston position. Predictions for filling lie in average within 5% from actual values, predictions for systemic afterload (AoPmean , AoPsys ) and mean pulmonary afterload (PAPmean ) lie in average within 9% from actual values. Predictions for systolic pulmonary afterload (PAPsys ) present an average deviation of 14%. The estimation models show satisfactory prediction and confidence intervals and are thus suitable to estimate hemodynamic parameters. This method and derived estimation models are a valuable alternative to implanted sensors and are an essential step for the development of a physiological control algorithm for a fully implantable TAH.
Effect of Glycerol Pretreatment on Levoglucosan Production from Corncobs by Fast Pyrolysis (2017)

In this manuscript, glycerol was used in corncobs' pretreatment to promote levoglucosan production by fast pyrolysis first and then was further utilized as raw material for chemicals production by microbial fermentation. The effects of glycerol pretreatment temperatures (220⁻240 °C), time (0.5⁻3 h) and solid-to-liquid ratios (5⁻20%) were investigated. Due to the accumulation of crystalline cellulose and the removal of minerals, the levoglucosan yield was as high as 35.8% from corncobs pretreated by glycerol at 240 for 3 h with a 5% solid-to-liquid ratio, which was obviously higher than that of the control (2.2%). After glycerol pretreatment, the fermentability of the recovered glycerol remaining in the liquid stream from glycerol pretreatment was evaluated by <i>Klebsiella pneumoniae</i>. The results showed that the recovered glycerol had no inhibitory effect on the growth and metabolism of the microbe, which was a promising substrate for fermentation. The value-added applications of glycerol could reduce the cost of biomass pretreatment. Correspondingly, this manuscript offers a green, sustainable, efficient and economic strategy for an integrated biorefinery process.
Synaptic delay based artificial neural networks and discrete time backpropagation applied to QRS complex detection (2002)

In this paper we make use of an extension of the backpropagation algorithm to discrete time feedforward networks that include internal time delays in the synapses. The structure of the network is similar to the one presented by Day-Davenport (1993), that is, in addition to the weights of the synaptic connections, we model their length through a parameter that indicates the delay a discrete event suffers when going from the origin neuron to the target neuron through a synaptic connection. Like the weights, these delays are also trainable, and a training algorithm can be obtained that is almost as simple as the backpropagation algorithm, and which is really an extension of it. We present an application of these networks to the task of identifying normal QRS and ventricular QRS complexes in an ECG signal with the network receiving the signal sequentially, that is, no windowing or segmentation is applied.
Masking Kernel for Learning Energy-Efficient Representations for Speaker Recognition and Mobile Health (2023)

Modern smartphones possess hardware for audio acquisition and to perform speech processing tasks such as speaker recognition and health assessment. However, energy consumption remains a concern, especially for resource-intensive DNNs. Prior work has improved the DNN energy efficiency by utilizing a compact model or reducing the dimensions of speech features. Both approaches reduced energy consumption during DNN inference but not during speech acquisition. This paper proposes using a masking kernel integrated into gradient descent during DNN training to learn the most energy-efficient speech length and sampling rate for windowing, a common step for sample construction. To determine the most energy-optimal parameters, a masking function with non-zero derivatives was combined with a low-pass filter. The proposed approach minimizes the energy consumption of both data collection and inference by 57%, and is competitive with speaker recognition and traumatic brain injury detection baselines.
ON THE DESIGN AND ANALYSIS OF ACOUSTIC HORNS FOR ULTRASONIC WELDING (2013)

The acoustic horn plays a very vital part in high energy ultrasonic machining, and its design is critical to the quality and the efficiency of machining. This paper performs the analysis and design of acoustic horns for ultrasonic machining by employing ANSYS finite element software. The results indicate that not only the natural frequencies of horns designed by theoretical models are more close to the vibration frequencies of ultrasonic generators, but also their amplitudes are superior to commercially available horns.
Identification and characterization of a neutral endopeptidase activity in Aplysia californica (1993)

Kidney plasma membranes of Aplysia californica were shown to contain an endopeptidase activity which cleaved [Leu]enkephalin (Tyr-Gly-Gly-Phe-Leu) and [Leu]enkephalinamide (Tyr-Gly-Gly-Phe-Leu-NH2) at the Gly3-Phe4 bond, as determined by reverse-phase h.p.l.c. analysis of metabolites. The optimal pH was shown to be 6.5. The bivalent cation chelating agent, 1,10-phenanthroline protected [Leu]enkephalin from degradation, suggesting that this enzyme is a metallopeptidase. The degradation of [Leu]enkephalin was also abolished by the neutral endopeptidase-24.11 inhibitors RB104 (2-[(3-iodo-4-hydroxyl)-phenylmethyl]-4-N-[3-(hydroxyamino-3-oxo-1- phenylmethyl)-propyl]amino-4-oxobutanoic acid), HABCO-Gly [(3-hydroxy-aminocarbonyl-2-benzyl-1-oxypropyl)glycine], phosphoramidon and thiorphan, with IC50 values of 1 nM, 1 microM, 20 microM and 30 microM respectively. By contrast, the angiotensin-converting enzyme inhibitor captopril and the serine proteinase inhibitor phenylmethanesulphonyl fluoride were without effect. Phase separation experiments using Triton X-114 showed that about 64% of the neutral endopeptidase activity in the Aplysia kidney membrane corresponds to an integral membrane protein. A specific radioiodinated inhibitor ([125I]RB104) was shown to bind the Aplysia endopeptidase with high affinity; the KD and Bmax. values were 21 +/- 5 pM and 20.3 +/- 5 fmol/mg of proteins respectively. This inhibitor was used to determine the molecular form of the enzyme, after separation of solubilized membrane proteins on SDS/PAGE and transfer on to nitrocellulose membranes. A single protein band with an apparent molecular mass of 140 kDa was observed. The labelling was abolished by specific neutral endopeptidase inhibitors. This study provides the first biochemical characterization of an endopeptidase with catalytic properties similar to those of neutral endopeptidase-24.11 in the mollusc Aplysia californica.
An introduction to the architecture of the Intel iAPX 432 (1983)

The paper describes salient architectural features of the Intel iAPX 432, a recent innovative microprocessor design. It is intended as a companion to a recently published paper (Witten, 1981) which surveys the architectures of the new generation of 16-bit microprocessors, but which was written prior to the announcement of the iAPX 432. The novelty of the new processor lies chiefly in its sophisticated segmentation structure and the design of its instruction set; these are covered in a tutorial fashion and related to earlier developments in computer architecture
The phenolic constituents and free radical scavenging activities of Gynura formosana Kiamnra (2004)

Abstract Gynura formosana Kiamnra (Compositae) is a herbal folk medicine that is a popular vegetable in Taiwan. The free‐radical scavenging activities of a 70% aqueous acetone extract from the herb G formosana were evaluated. Bioassay‐guided fractionation, column separation on Diaion, Toyopearl HW 40(C), Sephadex LH‐20 and MCI CHP20P, and high‐performance liquid chromatography (HPLC) were used to isolate for the first time in G formosana four potent phenolics [caffeic acid ( I ), quercetin 3‐ O ‐rutinoside ( II ), kaempferol 3‐ O ‐rutinoside ( III ) and kaempferol 3‐ O ‐robinobioside ( IV )]. The IC 50 values of 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging activity for compounds I – IV were 6.7, 7.7, 300.3 and 286.7 µ M , respectively, and, for superoxide radical scavenging activity, they were 187.3, 25.8, 55.3 and 87.4 µ M , respectively. Using a spin trapping electron spin resonance (ESR) method, caffeic acid ( I ) and quercetin 3‐ O ‐rutinoside ( II ) exhibited good hydroxyl radical activity. The free radical scavenging activity of G formosana phenolics may improve the economic value of this herb and assist in its development as a health food. Copyright © 2004 Society of Chemical Industry
Photoacoustic imaging probe for detecting lymph nodes and spreading of cancer at various depths (2017)

We propose a compact and easy to use photoacoustic imaging (PAI) probe structure using a single strand of optical fiber and a beam combiner doubly reflecting acoustic waves for convenient detection of lymph nodes and cancers. Conventional PAI probes have difficulty detecting lymph nodes just beneath the skin or simultaneously investigating lymph nodes located in shallow as well as deep regions from skin without any supplementary material because the light and acoustic beams are intersecting obliquely in the probe. To overcome the limitations and improve their convenience, we propose a probe structure in which the illuminated light beam axis coincides with the axis of the ultrasound. The developed PAI probe was able to simultaneously achieve a wide range of images positioned from shallow to deep regions without the use of any supplementary material. Moreover, the proposed probe had low transmission losses for the light and acoustic beams. Therefore, the proposed PAI probe will be useful to easily detect lymph nodes and cancers in real clinical fields.