gebhart/patrepeval huggingface dataset:
Parent–Daughter Transmission of the Androgen Receptor Gene as an Explanation of the Effect of Father Absence on Age of Menarche (2002)

Based on an evolutionary theory of socialization, Belsky and colleagues proposed that girls exposed to a stressful environment, especially when due to father absence in the first 7 years of life, showed an early onset of puberty, precocious sexuality, and unstable relationships as adults. The authors of this article examined an alternative explanation that a variant X-linked androgen receptor (AR) gene, predisposing the father to behaviors that include family abandonment, may be passed to their daughters causing early puberty, precocious sexuality, and behavior problems. The results of a study of 121 White males and 164 White females showed a significant association of the short alleles of the GGC repeat polymorphism of the AR gene with a range of measures of aggression and impulsivity, increased number of sexual partners, sexual compulsivity, and lifetime number of sex partners in males; and paternal divorce, father absence, and early age of menarche in females. These findings support a genetic explanation of the Belsky psychosocial evolutionary hypothesis regarding the association of fathers' absence and parental stress with early age of onset of menarche and early sexual activity in their daughters. A genetic explanation of the father absence effect is proposed in which fathers carrying the AR alleles are more likely to abandon a marriage (father absence) and pass those alleles to their daughters in whom they produce an earlier age of menarche and behavioral problems.
Application of Third-Order Transfer Functions for Edge Enhancement of Signals from Scanned Imaging Systems (1974)

Whenever images are reproduced by the utilization of a time-sequential signal obtained by electron beam scanning or by flying-spot light-scanning of photo-conductive thin-films, etc., onto which an optical image is focused, lack of edge resolution occurs. This is due to a number of intrinsic, uncontrollable factors of the semiconductor, e.g., its finite thickness, finite size of the scanning beam, etc. Such lack of edge resolution makes difficult the determination of the exact configurations of imaged objects. The present paper describes a linear network composed of an operational amplifier arrangement which allows controllable steepening (crispening) of edge resolution even when the peaks of the edges are overemphasized. This is accomplished without causing the post-transient oscillations which conventional devices tend to introduce. The mathematical relationships of the electronic crispening set-up are derived, and transfer functions in the Laplacefrequency-, and time domains are analyzed. The Nyquist diagram of a typical arrangement shows that the system is stable even when it produces, from a unit step input, an output signal with an overshoot of 250%. Further the resulting signal is free of oscillations, in contrast to the second order system which exhibits permanent oscillations when producing an overshoot of only 100%. The phase and amplitude behavior for the second and third order system are compared. It is shown that the phase of the second order system is an increasing function of frequency with a steep slope at the critical value whereas the third order system exhibits a gradually increasing and then decreasing phase. Further, the amplitude response of the second order system rises sharply as resonance is approached, wrhile for the third order system there is a gradual peaking of the amplitude characteristic. The smoothing effect of the system on a signal exhibiting white noise is demonstrated; the out-put signal being virtually free of any noise components.
Diabetes Risk Reduction Diet and Survival after Breast Cancer Diagnosis (2021)

Type II diabetes is associated with poor breast cancer prognosis. To study the association between a diabetes risk reduction diet (DRRD) and survival following breast cancer, we followed 8,482 women with breast cancer from two large cohort studies. Information on diet and other factors was repeatedly measured in validated questionnaires every two to four years. The DRRD includes 9 components: higher intakes of cereal fiber, coffee, nuts, whole fruits and polyunsaturated/saturated fat ratio; and lower glycemic index, trans fat, sugar-sweetened beverages, and red meat. Cumulative average DRRD score was calculated using repeated measures of postdiagnostic diet. Deaths were assessed by family members or via National Death Index. Multivariable-adjusted HRs and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. During a median of 14 years of follow-up since diagnosis, 2,600 deaths occurred among participants, 1,042 of which were due to breast cancer. Women with higher postdiagnostic DRRD score had a 20% lower risk of breast cancer-specific mortality (top vs. bottom quintile HR = 0.80; 95% CI = 0.65-0.97; <i>P</i> <sub>trend</sub> = 0.02) and 34% lower risk of all-cause mortality (HR = 0.66; 95% CI = 0.58-0.76; <i>P</i> <sub>trend</sub> < 0.0001). Compared with women who consistently had lower score (≤median) before and after diagnosis, those whose score improved from low to high had a lower risk of breast cancer-specific mortality (HR = 0.77; 95% CI = 0.62-0.95) and overall mortality (HR = 0.85; 95% CI = 0.74-0.97). These findings demonstrate that greater adherence to DRRD was associated with better survival, suggesting postdiagnosis dietary modification consistent with type II diabetes prevention may be important for breast cancer survivors. SIGNIFICANCE: This study suggests that greater adherence to the diabetes risk reduction diet after diagnosis associates with improved survival outcomes among a large number of breast cancer survivors.
Chromatographic analysis of salicylic compounds in different species of the genus Salix (2007)

The separation of nine phenol glycosides--salicin, salicortin, 2'-acetylsalicortin, populin, tremulacin, salidroside, triandrin, picein and helicin--by normal phase (NP), reversed phase (RP) HPLC techniques and a coupling of NP and RP monolithic silica columns was studied. Among the above nine compounds only five--salicin, populin, tremulacin, salidroside and triandrin--were resolved in an NP system with a mobile phase comprising hexane/isopropanol/methanol (87:12:1, v/v/v). Optimized separation was performed with two coupled monolithic silica columns of different polarity (bare silica and RP-18). The method was applied to verify the presence of salicylic compounds and other phenolic derivatives in the bark of six species from the genus Salix, namely S. purpurea, S. daphnoides clone 1095, S. alba clone 1100, S. triandra, S. viminalis, and S. herbacea. Gradient elution with a mobile phase composed of acetonitrile and water containing 0.05% of trifluoroacetic acid, with increasing acetonitrile concentration from 3% to 48%, was chosen as optimal. For the selective detection of the salicylic compounds, an evaporative light scattering detector was employed along with a UV detector. The differences in the composition of phenols in the different plant materials were confirmed. Additionally, it must be emphasized that for the first time the presence of 2'-acetylsalicortin was revealed in S. alba clone 1100. Furthermore, an SPE-HPLC method was developed for the rapid analysis of the salicin content, analyzed as free and total fraction, in willow barks. The determined concentrations of total salicin varied from 25.4 mg/g in S. alba clone 1100 to 96.47 mg/g in S. daphnoides clone 1095.
Polylactic Acid/Poly(vinylpyrrolidone) Co-Electrospun Fibrous Membrane as a Tunable Quercetin Delivery Platform for Diabetic Wounds (2023)

Diabetic wound infections (DWI) represent one of the most costly and disruptive complications in diabetic mellitus. The hyperglycemic state induces a persistent inflammation with immunological and biochemical impairments that promotes delayed wound healing processes and wound infection that often results in extended hospitalization and limb amputations. Currently, the available therapeutic options for the management of DWI are excruciating and expensive. Hence, it is essential to develop and improve DWI-specific therapies able to intervene on multiple fronts. Quercetin (QUE) exhibits excellent anti-inflammatory, antioxidant, antimicrobial and wound healing properties, which makes it a promising molecule for the management of diabetic wounds. In the present study, Poly-lactic acid/poly(vinylpyrrolidone) (PP) co-electrospun fibers loaded with QUE were developed. The results demonstrated a bimodal diameter distribution with contact angle starting from 120°/127° and go to 0° in less than 5 s indicating the hydrophilic nature of fabricated samples. The release QUE kinetics, analyzed in simulated wound fluid (SWF), revealed a strong initial burst release, followed by a constant and continuous QUE release. Moreover, QUE-loaded membranes present excellent antibiofilm and anti-inflammatory capacity and significantly reduce the gene expression of M1 markers tumor necrosis factor (TNF)-α, and IL-1β in differentiated macrophages. In conclusion, the results suggested that the prepared mats loaded with QUE could be a hopeful drug-delivery system for the effective treatment of diabetic wound infections.
In vitro reconstitution of human B-cell ontogeny: from CD34(+) multipotent progenitors to Ig-secreting cells. (1998)

We describe a long-term, in vitro culture system initiated with CD34(+) or CD34(+)CD38(-) umbilical cord blood hematopoietic progenitors that supports normal human B-lineage development, including the production of mature Ig-secreting B cells. In the first stage (human B-progenitor long-term culture [HB-LTC]), CD34(+) hematopoietic progenitors are cultured on the murine stromal cell line, S17, leading to the sustained production of large numbers of CD10(+), CD19(+) early B progenitors. Reverse transcriptase-polymerase chain reaction (RT-PCR) and three-parameter flow cytometry for VpreB (surrogate light chain), cytoplasmic mu chain, and surface IgM expression were used to characterize the CD19(+) B progenitors present within these cultures. This analysis showed distinct B-lineage subpopulations, including pro-B cells, cycling pre-B cells, and IgM+, IgD-/+ immature B cells. The limited expansion of IgM+ B cells and the immature surface phenotype of this population (IgM+, IgD+, CD10(+), CD38(+)) suggested that HB-LTC conditions were unable to provide appropriate signals for further differentiation. A second culture stage was used to determine if these immature B cells were functionally competent. Purified CD19(+) cells were transferred onto fibroblasts expressing human CD40-ligand in the presence of IL-10 and IL-4. This lead to cell proliferation, modulation of the IgM+ cell surface phenotype to one consistent with an activated mature B cell, secretion of Ig, and isotype switching. Notably, IgM and IgG producing B cells were also generated using two-stage cultures established with highly purified multipotent CD34(+)CD38(-) hematopoietic stem cell progenitors. This culture model should permit detailed in vitro analysis and genetic manipulation of the major transition points in human B ontogeny, beginning with commitment to the B lineage and leading to development and activation of mature B cells.
Model Predictive Control for the Operation of Building Cooling Systems (2011)

This brief presents a model-based predictive control (MPC) approach to building cooling systems with thermal energy storage. We focus on buildings equipped with a water tank used for actively storing cold water produced by a series of chillers. First, simplified models of chillers, cooling towers, thermal storage tanks, and buildings are developed and validated for the purpose of model-based control design. Then an MPC for the chilling system operation is proposed to optimally store the thermal energy in the tank by using predictive knowledge of building loads and weather conditions. This brief addresses real-time implementation and feasibility issues of the MPC scheme by using a simplified hybrid model of the system, a periodic robust invariant set as terminal constraints, and a moving window blocking strategy. The controller is experimentally validated at the University of California, Merced. The experiments show a reduction in the central plant electricity cost and an improvement of its efficiency.
Load-Independent Spin Power Losses of a Spur Gear Pair: Model Formulation (2009)

A physics-based fluid mechanics model is proposed to predict spin power losses of gear pairs due to oil churning and windage. While the model is intended to simulate oil churning losses in dip-lubricated conditions, certain components of it apply to air windage losses as well. The total spin power loss is defined as the sum of (i) power losses associated with the interactions of individual gears with the fluid, and (ii) power losses due to pumping of the oil at the gear mesh. The power losses in the first group are modeled through individual formulations for drag forces induced by the fluid on a rotating gear body along its periphery and faces, as well as for eddies formed in the cavities between adjacent teeth. Gear mesh pumping losses will be predicted analytically as the power loss due to squeezing of the lubricant, as a consequence of volume contraction of the mesh space between mating gears as they rotate. The model is applied to a unity-ratio spur gear pair to quantify the individual contributions of each power loss component to the total spin power loss. The influence of operating conditions, gear geometry parameters, and lubricant properties on spin power loss are also quantified at the end. A companion paper (Seetharaman et al., 2009, “Oil Churning Power Losses of a Gear Pair: Experiments and Model Validation,” ASME J. Tribol., 131, p. 022202) provides comparisons to experiments for validation of the proposed model.
Kyrix: Interactive Pan/Zoom Visualizations at Scale (2019)

Abstract Pan and zoom are basic yet powerful interaction techniques for exploring large datasets. However, existing zoomable UI toolkits such as Pad++ and ZVTM do not provide the backend database support and data‐driven primitives that are necessary for creating large‐scale visualizations. This limitation in existing general‐purpose toolkits has led to many purpose‐built solutions (e.g. Google Maps and ForeCache) that address the issue of scalability but cannot be easily extended to support visualizations beyond their intended data types and usage scenarios. In this paper, we introduce Kyrix to ease the process of creating general and large‐scale web‐based pan/zoom visualizations. Kyrix is an integrated system that provides the developer with a concise and expressive declarative language along with a backend support for performance optimization of large‐scale data. To evaluate the scalability of Kyrix, we conducted a set of benchmarked experiments and show that Kyrix can support high interactivity (with an average latency of 100 ms or below) on pan/zoom visualizations of 100 million data points. We further demonstrate the accessibility of Kyrix through an observational study with 8 developers. Results indicate that developers can quickly learn Kyrix's underlying declarative model to create scalable pan/zoom visualizations. Finally, we provide a gallery of visualizations and show that Kyrix is expressive and flexible in that it can support the developer in creating a wide range of customized visualizations across different application domains and data types.
Molecularly Smooth Self-Assembled Monolayer for High-Mobility Organic Field-Effect Transistors (2016)

Despite the need for molecularly smooth self-assembled monolayers (SAMs) on silicon dioxide surfaces (the most common dielectric surface), current techniques are limited to nonideal silane grafting. Here, we show unique bioinspired zwitterionic molecules forming a molecularly smooth and uniformly thin SAM in "water" in <1 min on various dielectric surfaces, which enables a dip-coating process that is essential for organic electronics to become reality. This monomolecular layer leads to high mobility of organic field-effect transistors (OFETs) based on various organic semiconductors and source/drain electrodes. A combination of experimental and computational techniques confirms strong adsorption (W<sub>ad</sub> > 20 mJ m<sup>-2</sup>), uniform thickness (∼0.5 or ∼1 nm) and orientation (all catechol head groups facing the oxide surface) of the "monomolecular" layers. This robust (strong adsorption), rapid, and green SAM represents a promising advancement toward the next generation of nanofabrication compared to the current nonuniform and inconsistent polysiloxane-based SAM involving toxic chemicals, long processing time (>10 h), or heat (>80 °C).
Adiponectin as a Link Between Type 2 Diabetes and Vascular NADPH Oxidase Activity in the Human Arterial Wall: The Regulatory Role of Perivascular Adipose Tissue (2014)

Oxidative stress plays a critical role in the vascular complications of type 2 diabetes. We examined the effect of type 2 diabetes on NADPH oxidase in human vessels and explored the mechanisms of this interaction. Segments of internal mammary arteries (IMAs) with their perivascular adipose tissue (PVAT) and thoracic adipose tissue were obtained from 386 patients undergoing coronary bypass surgery (127 with type 2 diabetes). Type 2 diabetes was strongly correlated with hypoadiponectinemia and increased vascular NADPH oxidase-derived superoxide anions (O2˙(-)). The genetic variability of the ADIPOQ gene and circulating adiponectin (but not interleukin-6) were independent predictors of NADPH oxidase-derived O2˙(-). However, adiponectin expression in PVAT was positively correlated with vascular NADPH oxidase-derived O2˙(-). Recombinant adiponectin directly inhibited NADPH oxidase in human arteries ex vivo by preventing the activation/membrane translocation of Rac1 and downregulating p22(phox) through a phosphoinositide 3-kinase/Akt-mediated mechanism. In ex vivo coincubation models of IMA/PVAT, the activation of arterial NADPH oxidase triggered a peroxisome proliferator-activated receptor-γ-mediated upregulation of the adiponectin gene in the neighboring PVAT via the release of vascular oxidation products. We demonstrate for the first time in humans that reduced adiponectin levels in individuals with type 2 diabetes stimulates vascular NADPH oxidase, while PVAT "senses" the increased NADPH oxidase activity in the underlying vessel and responds by upregulating adiponectin gene expression. This PVAT-vessel interaction is identified as a novel therapeutic target for the prevention of vascular complications of type 2 diabetes.
Role of sulfhydryl groups in induction of cell surface down-modulation and shedding of extracellular domain of human TNF receptors in human histiocytic lymphoma U937 cells. (1994)

The interaction of different polypeptide growth factors with their cell surface receptors, which are typically rich in cysteine, is modulated by sulfhydryl (SH) reagents. Because the extracellular domain of both human TNFRs are likewise rich in cysteine residues, we examined the effect of SH reagents on these receptors in human histiocytic lymphoma U937 cells, which express both p60 and p80 forms. Iodoacetamide induced down-regulation of cell surface TNFRs in a dose- and time-dependent manner. Down-regulation was complete at 10 mM IAA for 1 h at 37 degrees C. The decrease was minimal at 4 degrees C. The down-modulation was also observed with other cell-permeable and -impermeable thiol reagents. The expression of other cell surface molecules such as CD3, CD11b, CD23, and CD25 were not affected. IAA induced the down-regulation of TNFR on cells of both epithelial and myeloid origin. With the use of receptor-specific Abs, we found that the kinetics of down-modulation of the p60 and p80 receptors by IAA were very similar. We also found that down-modulation was not a result of internalization but rather of the shedding of the receptors, as ascertained by receptor-ligand cross-linking analysis, immunoassay, Western blot analysis, and ligand-blot analysis. When TNFRs with a molecular mass of 80 kDa disappeared from the cell surface, a 42-kDa polypeptide appeared in the medium. Thus, we demonstrate that SH reagents down-regulate TNFRs by inducing shedding of both receptors from the cell surface, most likely by activating an endopeptidase that cleaves the receptor.
Flexible Phased Array Shape Reconstruction (2021)

Lightweight, flexible phased arrays enable new applications by dynamically changing shape during deployment and operation. However, these shape changes must be tracked and accounted for by changing the element excitation in order for the array to continue proper operation. We propose a framework for reconstructing the shape of a flexible phased array using only measurements of mutual coupling between the antennas in the array. The framework is demonstrated using a passive 2.5 GHz phased array and fixed to 8 different frames of known radii of convex and concave curvature. Our results show the ability to reconstruct shape to within ≈ 0.04λ position error, even in cases where the phased array is bent dramatically, without any advanced knowledge or additional information. The framework is modular and can be easily adapted to other phased array systems with different antennas, frequencies, and physical constraints.
Defining ‘progression’ and triggers for curative intervention during active surveillance (2015)

Active surveillance for low-risk prostate cancer is well tolerated in the intermediate-long term time frame. Further refinement of the surveillance approach is ongoing, incorporating MRI, targeted biopsies and molecular biomarkers to improve appropriate patient selection and triggers for intervention.
PROSE Treatment for Ocular Chronic Graft-Versus-Host Disease as a Clinical Network Expands (2015)

PROSE treatment of ocular cGVHD has increased in the last decade with the establishment of BostonSight network clinics across the United States. Patients treated at network clinics showed similar levels of baseline visual function and SRGHS, and achieved a similar high level of improvement in visual function as those treated at the main center. Patient-reported measures of functional status are useful in evaluating treatment options for patients with cGVHD. PROSE treatment has significant positive impact on the visual function of patients with ocular cGVHD regardless of whether the patient is treated at the main center or at a network site.
Negative‐working photoresist based on a first‐generation dendrimer consisting of 4,4‐diphenylpentyloxy units (2005)

Abstract A first‐generation dendrimer ( 2 ), containing phenol groups in the exterior for solubilization in aqueous alkaline solutions, was evaluated as a new negative‐working, alkaline‐developable photoresist material. A negative‐working photoresist based on 2 , 4,4′‐methylenebis[2,6‐bis(hydroxymethyl)phenol] as a crosslinker, and diphenyliodonium 9,10‐dimethoxyanthracene‐2‐sulfonate as a photoacid generator was demonstrated. This resist gave a clear negative pattern through postbaking at 90 °C after exposure to UV light, which was followed by development with a 2.38% aqueous tetramethyl ammonium hydroxide solution at room temperature. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 1210–1215, 2005
Diastereoselective Synthesis of Fused Lactone-Pyrrolidinones; Application to a Formal Synthesis of (−)-Salinosporamide A (2014)

A mild, diastereoselective synthesis of fused lactone-pyrrolidinones using an oxidative radical cyclization is reported. The methodology is demonstrated in a formal synthesis of (-)-salinosporamide A.
Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity (2019)

This paper shows that quantitative leptin expression is controlled by redundant cis elements and trans factors that interact with the proximal promoter together with a long noncoding RNA.