gebhart/patrepeval huggingface dataset:
The Structure of Costatolide1a,b (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Structure of Costatolide1a,bGeorge H. Stout and Kenneth L. StevensCite this: J. Org. Chem. 1964, 29, 12, 3604–3609Publication Date (Print):December 1, 1964Publication History Published online1 May 2002Published inissue 1 December 1964https://pubs.acs.org/doi/10.1021/jo01035a041https://doi.org/10.1021/jo01035a041research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development and Performance Tests of the Waste Water Diffusers using Acoustic Resonance and Oscillatory Pulsation (1996)

Using the acoustic resonances and oscillatory pulsations considered as the branch of wave technologies, the concept of the acoustic resonance diffusers for waste water treatment which maximize the oxygen transfer efficiency in gas-liquid two phase medium have been proposed, and studies for the principles and performance tests were accomplished. Besides, the design concepts for the low pressure Helmholtz resonator, cylinder and annular type reflection resonator and combined type resonance system have been implemented. The acoustic resonance energy which can speed up the mass transfer process increase the oxygen transfer efficiency, and periodic pulsations generated from the instability of air jet from nozzle make very small air bubbles. Then, the annular type jet resonator(AJR) applying these two principles successfully was evalulated as the most promising device and also the efficiency showing better than conventional diffusers has been verified experimentally.
Electrical stimulation for lower urinary tract dysfunction in children: A systematic review of the literature (2011)

The literature in the area of interest is sparse. Parasacral TENS has been shown to be more effective than sham in randomized trials in treating OAB. This deserves further research to elucidate the optimal parameters and the children for whom it is most useful.
On-chip Cytometry using Lensless Digital Holography (2009)

We illustrate a high-throughput on-chip cytometry platform that records the holographic diffraction pattern of cells/bacteria without using any lenses. These digital in-line holograms contain finger-print information of each cell/bacteria type enabling unambiguous recognition of different micro-objects using pattern recognition.
Transmission of 32 ETDM channels at 40 Gbit/s (1.28Tbit/s capacity) over 3 × 100 km of TeraLight™ fibre (2001)

The transmission of 32 channels at 40 Gbit/s is demonstrated over 3 × 100 km of TeraLight™ fibre. The result was obtained with full ETDM terminal equipment and hybrid Raman/erbium amplifiers.
hERG1 Channels Regulate VEGF-A Secretion in Human Gastric Cancer: Clinicopathological Correlations and Therapeutical Implications (2014)

Our results show that hERG1 (i) is aberrantly expressed in human gastric cancer since its early stages; (ii) drives an intracellular pathway leading to VEGF-A secretion; (iii) can be exploited to identify a gastric cancer patients' group where a combined treatment with antiangiogenic drugs and noncardiotoxic hERG1 inhibitors could be proposed.
Synthesis and biological activities of tachykinin and opioid-related compounds, synthesis of unusual amino acids, and the investigations into the smooth muscle pharmacology of tachykinins. (1989)

Eight cyclic analogues of Substance P were made in order to investigate the conformation of the C-terminal end of the peptide. These analogues were designed to test three literature models describing the active conformation of substance P. Although the potencies of the analogues were low (in the micromolar range), our results support Cotrait's and Hospital's model (1986). Several substance P antagonists were synthesized. These compounds did not demonstrate agonistic activity nor anatagonistic activity. The tryptophan side chain is contributing to the antagonistic activity of these analogues, and not just the chirality of the α-carbon. Highly potent and selective photoaffinity ligands of H-Tyr-D-Pen-Gly-Phe-D-Pen-OH (DPDPE) and D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH₂ (CTP) were synthesized. These compounds will be useful in the isolation of δ and μ opioid receptors. Several new amino acids designed and synthesized to contain both the natural amino acid side chain and a thiol group which can be used to make disulfide constraints. The racemic amino acids made were as follows: (1) 2-amino-4-methyl-2- [(p-methylbenzyl)thiomethyl] pentanoic acid; (2) 2-amino-2- [(p-methylbenzyl)thiomethyl] -3-phenylpropanoic acid; (3) 2-amino-e- [(p-methylbenzyl)thio] pentanoic acid; and (4) 2-amino-3- [(p-methylbenzyl)-thio] -3-phenyl-pentanoic acid. These amino acids will be useful in the conformational restriction of peptides. To investigate the δ-opioid receptor conformation proposed for DPDPE by Hruby et al. (1988) and the μ-opioid receptor conformation proposed for Tyr-c [Abu₂,Gly,Phe,Leu] by Mierke et al. (1988), constrained phenylalanine amino acids were incorporated into H-Try-D-Pen-Gly-Phe-D-Pen-OH (DPDPE) in the four position. Our results indicate that these models are correct. And in an investigation into the physical-chemical properties of the delta opioid receptor, our results suggest that the δ receptor topochemical site for the Phe⁴ residue contains a partial positive charge on its surface and has specific steric requirements.
A Real-Time Polymerase Chain Reaction Assay of the BacteriumEdwardsiella ictaluriin Channel Catfish (2003)

A rapid (4.5-h) and sensitive assay based on polymerase chain reaction (PCR) was developed to facilitate the early detection of Edwardsiella ictaluri in channel catfish Ictalurus punctatus. A 129-base-pair fragment of a sequence specific to E. ictaluri was amplified with both standard and real-time (quantitative) PCR. The sensitivity of detection was determined to be as low as the equivalent of 2.5 cells in DNA samples from both E. ictaluri cells and mixtures of blood from noninfected catfish and E. ictaluri cells. Infection levels (as determined by real-time PCR) in blood from experimentally challenged fish were compared with brain–heart-infusion-cultured bacterial colony counts to assess the accuracy of the PCR assay. The PCR-based detection level (the equivalent of 105–108 cells/mL) was comparable to that of traditional culturing techniques (106–107 cells/mL). In future applications, this assay will be applied in a comprehensive breeding program to select channel catfish that are resistant to enteric septicemia of catfish.
Current Practices of Adjunctive Therapy for Pertussis at Six Canadian Tertiary Care Pediatric Hospitals (1997)

Pertussis treatment varied widely among the six hospitals studied, and was often not consistent with current Canadian recommendations. The results will allow practitioners to place their practices in a national perspective and provide a baseline for further studies.
Auditory feedback through continuous control of crumpling sound synthesis (2008)

A realtime model for the synthesis of crumpling sounds ispresented. By capturing the statistics of short sonic transients which give rise to crackling noise, it allows for a consistent description of a broad spectrum of audible physical processes which emerge in several everyday interaction contexts.The model drives a nonlinear impactor that sonifies every transient, and it can be parameterized depending on the physical attributes of the crumpling material. Three different scenarios are described, respectively simulating the foot interaction with aggregate ground materials, augmenting a dining scenario, and affecting the emotional content of a footstep sequence. Taken altogether, they emphasize the potential generalizability of the model to situations in which a precise control of auditory feedback can significantly increase the enactivity and ecological validity of an interface.
[Characteristics and in vitro imaging study of matrix metalloproteinase-2 targeting activable cell-penetrating peptide]. (2007)

The study in vitro suggests that the MMP-2 activable cell-penetrating peptides bearing contrast media can detect the MMP2-positive tumor cell.
Cross-Linked Gold-Nanoparticle Membrane Resonators as Microelectromechanical Vapor Sensors (2017)

We report a novel approach for the detection of volatile compounds employing electrostatically driven drumhead resonators as sensing elements. The resonators are based on freestanding membranes of alkanedithiol cross-linked gold nanoparticles (GNPs), which are able to sorb analytes from the gas phase. Under reduced pressure, the fundamental resonance frequency of a resonator is continuously monitored while the device is exposed to varying partial pressures of toluene, 4-methylpentan-2-one, 1-propanol, and water. The measurements reveal a strong, reversible frequency shift of up to ∼10 kHz, i.e., ∼5% of the fundamental resonance frequency, when exposing the sensor to toluene vapor with a partial pressure of ∼20 Pa. As this strong shift cannot be explained exclusively by the mass uptake in the membrane, our results suggest a significant impact of analyte sorption on the pre-stress of the freestanding GNP membrane. Thus, our findings point to the possibility of designing highly sensitive resonators, which utilize sorption induced changes in the membrane's pre-stress as primary transduction mechanism.
Properties of ${\hbox{MgB}}_{2}$ Thin Films and SIS Junctions Fabricated Under Various Fabrication Conditions (2007)

We investigated the optimal conditions to fabricate MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> superconductor-insulator-superconductor junctions. By investigating thin film qualities obtained under various deposition conditions, we found that the critical temperature depended strongly on the Mg sputtering power. Although a higher Mg sputtering power increased the MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> thin film's critical temperature, the dependence of the zero resistance transition width suggested that the higher Mg deposition power produced Mg-rich thin Alms. To evaluate the gap voltage of MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> thin films on c-plane sapphire substrates, we fabricated superconductor- insulator-normal metal junctions and determined that the gap voltage of MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> was 2.0 mV. Using these MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> thin Alms, we produced an MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /SiC/MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> junction and an MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /AlN/MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> junction. For both of these SIS junctions, we obtained clear gap structures, but at this stage, the AlN insulator appeared to be better than the SiC insulator based on current-voltage characteristics. We found that the current-voltage characteristics depend on the MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> thin film quality when using an AlN insulator. Our TEM measurements revealed epitaxial growth of the lower MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> thin films and amorphous-like growth of the upper MgB <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> thin films. We obtained their depth profile with Auger electron spectroscopy, and the profile indicated that the trilayer has a nitrided and oxidized region at the insulator portion.
Automatic procedure for non-coplanar aberration compensation in lensless Fourier transform digital holography (2010)

As the lensless Fourier transform digital holography is applied into the microscopic phase-contrast imaging on the live cells, the motion of the cells will lead to the non-coplanarity phenomena between the object and the reference source. This could result in the imaging aberration. An effective and robust autofocus procedure based on the phase distribution is presented in the paper. With the initial measurement of the distance between the reference source and the hologram, the optimum parameters corresponding to the phase-contrast image can be achieved by a single hologram, combined with the linearity fitting. The lensless Fourier transform digital holographic system is built and the experiments on the phase-contrast imaging of the live cervical carcinoma cells are performed. Finally, the good experiment results are demonstrated. Both the theoretical analysis and the experimental investigation verify the feasibility and validity of the automatic procedure for the non-coplanar aberration compensation.
Application of plasma jet to the inhibition of the proliferation of hepatic malignant cells via reactive oxygen species generation (2019)

Abstract In vitro treatment of hepatic malignant cells with plasma‐activated medium conjugated with gemcitabine was investigated with a He plasma jet generated by a two‐ring dielectric barrier discharge (DBD) reactor. The DBD reactor was operated by high‐voltage pulses of alternating polarity (frequency: 20 kHz; pulse width: 4 µs). The electron density of plasma plume was estimated to be 9×10 12 to 10×10 12 cm −3 , and the jet temperature was around 36℃. The plasma jet exhibited the inhibitory effects on the growth of hepatic malignant cells via the generation of reactive oxygen species, which could be potentially applicative in anticancer therapies. The optimization of the operating parameters and configuration of the plasma jet would help increase the possibility in practical cancer treatments.
Bladder response to urethral flow in the awake ewe. (2001)

International audience
Robust stratification of breast cancer subtypes using differential patterns of transcript isoform expression (2017)

Breast cancer, the second leading cause of cancer death of women worldwide, is a heterogenous disease with multiple different subtypes. These subtypes carry important implications for prognosis and therapy. Interestingly, it is known that these different subtypes not only have different biological behaviors, but also have distinct gene expression profiles. However, it has not been rigorously explored whether particular transcriptional isoforms are also differentially expressed among breast cancer subtypes, or whether transcript isoforms from the same sets of genes can be used to differentiate subtypes. To address these questions, we analyzed the patterns of transcript isoform expression using a small set of RNA-sequencing data for eleven Estrogen Receptor positive (ER+) subtype and fourteen triple negative (TN) subtype tumors. We identified specific sets of isoforms that distinguish these tumor subtypes with higher fidelity than standard mRNA expression profiles. We found that alternate promoter usage, alternative splicing, and alternate 3'UTR usage are differentially regulated in breast cancer subtypes. Profiling of isoform expression in a second, independent cohort of 68 tumors confirmed that expression of splice isoforms differentiates breast cancer subtypes. Furthermore, analysis of RNAseq data from 594 cases from the TCGA cohort confirmed the ability of isoform usage to distinguish breast cancer subtypes. Also using our expression data, we identified several RNA processing factors that were differentially expressed between tumor subtypes and/or regulated by estrogen receptor, including YBX1, YBX2, MAGOH, MAGOHB, and PCBP2. RNAi knock-down of these RNA processing factors in MCF7 cells altered isoform expression. These results indicate that global dysregulation of splicing in breast cancer occurs in a subtype-specific and reproducible manner and is driven by specific differentially expressed RNA processing factors.
Model-driven systems development (2006)

Traditional systems development methods are designed to create a “point solution”—that is, a solution for a specific and static set of requirements. These methods result in systems that are sluggish in their response to dynamic conditions and changing requirements, expensive to maintain over extended periods of time, and prone to system failure. As an alternative to this approach, this paper describes a model-driven approach to systems development, which extends traditional systems engineering methods and is well-suited to a systems development environment characterized by rapidly changing conditions and requirements. We describe how model-driven systems development is performed by using the RUP® (Rational Unified Process® for Systems Engineering) architecture framework and transformation methods, which have been refined over eight years of field experience by Rational®, IBM, and our clients.
Towards automated optoelectrowetting on dielectric devices for multi-axis droplet manipulation (2013)

Lab-on-a-chip technology scales down multiple laboratory processes to a chip capable of performing automated biochemical analyses. Electrowetting on dielectric (EWOD) is a digital microfluidic lab-on-a-chip technology that uses patterned electrodes for droplet manipulation. The main limitations of EWOD devices are the restrictions in volume and motion of droplets due to the fixed size, layout, and addressing scheme of the electrodes. Optoelectrowetting on dielectric (OEWOD) is a recent technology that uses optical sources and electric fields for droplet actuation on a continuous surface. We describe an open surface light-actuated OEWOD device that can manipulate droplets of multiple volumes ranging from 1 to 50 μL at voltages below 45 V. To achieve lower voltage droplet actuation than previous open configuration devices, we added a dedicated dielectric layer of high dielectric constant (Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> with ε <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> of 9.1) and significantly reduced the thickness of the hydrophobic layer. The device is capable of transporting droplets at speeds as high as 12 mm/sec using a data projector as an optical source. We developed a multiple axis contact pad design to apply lateral electric fields along different axes to achieve multi-axis droplet movement. We demonstrated microfluidic operations including droplet merging, mixing, and parallel droplet motion. Further, the OEWOD device is capable of droplet transportation using a tablet computer's LCD screen as an optical source.
Function and solution structure of the Arabidopsis thaliana RALF8 peptide (2019)

We report the recombinant preparation from Escherichia coli cells of samples of two closely related, small, secreted cysteine-rich plant peptides: rapid alkalinization factor 1 (RALF1) and rapid alkalinization factor 8 (RALF8). Purified samples of the native sequence of RALF8 exhibited well-resolved nuclear magnetic resonance (NMR) spectra and also biological activity through interaction with a plant receptor kinase, cytoplasmic calcium mobilization, and in vivo root growth suppression. By contrast, RALF1 could only be isolated from inclusion bodies as a construct containing an N-terminal His-tag; its poorly resolved NMR spectrum was indicative of aggregation. We prepared samples of the RALF8 peptide labeled with <sup>15</sup> N and <sup>13</sup> C for NMR analysis and obtained near complete <sup>1</sup> H, <sup>13</sup> C, and <sup>15</sup> N NMR assignments; determined the disulfide pairing of its four cysteine residues; and examined its solution structure. RALF8 is mostly disordered except for the two loops spanned by each of its two disulfide bridges.
Comparison of gain recovery dynamics among multiple quantum-well optical amplifiers with different confinement structures (1991)

Semiconductor optical amplifiers fabricated from InGaAs/InGaAsP multiple quantum-well (MOW) laser diodes have demonstrated large saturation powers.1,2 Previously, we have reported that the gain recovery time in such amplifiers can be dominated by a fast time constant (<10 ps) assigned to carrier diffusion.3 Such a rapid recovery will be beneficial for applications to high-speed lightwave systems. In this work, we report a systematic study of the dependence of this rapid gain recovery process on the device structure and demonstrate that the results are indeed consistent with carrier diffusion. From these results it is clear that amplifier structures can be engineered for rapid gain recovery.
Constructive Neural Networks and Their Application to Ship Multidisciplinary Design Optimization (2007)

This paper presents a neural network-based response surface method for reducing the cost of computer-intensive optimizations for applications in ship design. In the approach, complex or costly analyses are replaced by a neural network, which is used to instantaneously estimate the value of the function(s) of interest. The cost of the optimization is shifted to the generation of (smaller) data sets used for training the network. The focus of the paper is on the use and analysis of constructive networks, as opposed to networks of fixed size, for treating problems with a large number of variables, say around 30. The advantages offered by constructive networks are emphasized, leading to the selection and discussion of the cascade correlation algorithm. This topology allows for efficient neural network determination when dealing with function representation over large design spaces without requiring prior experience from the user. During training, the network grows until the error on a small set (validation set), different from that used in the training itself (training set), starts increasing. The method is validated for a mathematical function for dimensions ranging from 5 to 30, and the importance of analyzing the error on a set other than the training set is emphasized. The approach is then applied to the automated computational fluid dynamics-based shape optimization of a fast ship configuration known as the twin H-body. The classical approach yields a design improvement of 26%, whereas the neural network-based method allows reaching a 34% improvement at one fifth of the cost of the former. Based on the analysis of the results, areas for future improvements and research are outlined. The results demonstrate the potential of the method in saving valuable development cycle time and increasing the performance of future ship designs.