gebhart/patrepeval huggingface dataset:
19.2 A 6.4pJ/Cycle Self-Tuning Cortex-M0 IoT Processor Based on Leakage-Ratio Measurement for Energy-Optimal Operation Across Wide-Range PVT Variation (2019)

Wireless sensors for IoT applications have become a prominent computing class and are typically severely power constrained. IoT devices are deployed in a wide range of environments and low power consumption must be guaranteed across a wide temperature range. The combination of dynamic voltage scaling (DVS) and adaptive body biasing (ABB) can achieve minimum total energy per cycle, where dynamic and leakage energy are at an optimal trade-off point [1]. However, due to the dependence of leakage on temperature and workload fluctuations over time, this optimal operating point requires runtime adjustment. Traditional approaches to track an optimal operating point involve repeated measurement of processor power inside a body-bias and supply voltage search loop. However, determining processor power consumption adds significant complexity and/or power overhead since it requires separate measurement of supply voltage and current followed by their multiplication.
Dominio público: Extrañas compañías (2009)

La integracion de cualquier aplicacion en las redes sociales es una opcion cada vez mas popular y los usos que se hacen de estas herramientas son cada vez mas innovadoras. Una de las herramientas que ha surgido recientemente es keynotetweet. Se trata como su nombre indica de la integracion de la aplicacion de presentaciones Keynote con Twitter.
Rat Parotid Gland Cell Differentiation in Three-Dimensional Culture (2010)

The use of polarized salivary gland cell monolayers has contributed to our understanding of salivary gland physiology. However, these cell models are not representative of glandular epithelium in vivo, and, therefore, are not ideal for investigating salivary epithelial functions. The current study has developed a three-dimensional (3D) cell culture model for rat Par-C10 parotid gland cells that forms differentiated acinar-like spheres on Matrigel. These 3D Par-C10 acinar-like spheres display characteristics similar to differentiated acini in salivary glands, including cell polarization, tight junction (TJ) formation required to maintain transepithelial potential difference, basolateral expression of aquaporin-3 and Na+/K+/2Cl- cotransporter-1, and responsiveness to the muscarinic receptor agonist carbachol that is decreased by the anion channel blocker diphenylamine-2-carboxylic acid or chloride replacement with gluconate. Incubation of the spheres in the hypertonic medium increased the expression level of the water channel aquaporin-5. Further, the proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma induced alterations in TJ integrity in the acinar-like spheres without affecting individual cell viability, suggesting that cytokines may affect salivary gland function by altering TJ integrity. Thus, 3D Par-C10 acinar-like spheres represent a novel in vitro model to study physiological and pathophysiological functions of differentiated acini.
TAT Peptide-Functionalized Gold Nanostars: Enhanced Intracellular Delivery and Efficient NIR Photothermal Therapy Using Ultralow Irradiance (2012)

Gold nanoparticles have great potential in plasmonic photothermal therapy (photothermolysis), but their intracellular delivery and photothermolysis efficiency have yet to be optimized. We show that TAT-peptide-functionalized gold nanostars (NS) enter cells significantly more than bare or PEGylated NS. The cellular uptake mechanism involves actin-driven lipid raft-mediated macropinocytosis, where particles primarily accumulate in macropinosomes but may also leak out into the cytoplasm. After 4-h incubation of TAT-NS on BT549 breast cancer cells, photothermolysis was accomplished using 850 nm pulsed laser under 0.2 W/cm(2) irradiation, below the maximal permissible exposure of skin. These results demonstrate the enhanced intracellular delivery and efficient photothermolysis of TAT-NS, promising agents in cancer therapy.
Matched test structures for accurate characterization in millimeter wave range (2014)

This paper, presents a novel methodology for small signal equivalent circuit extraction suitable for high frequency characterization up to mm-wave range. This methodology allows the de-embedding and the extraction of RF characteristics by the use of a smart matching at 50Ω of the transistor connected in GSG probe pads. The method has been validated first on a test module based on RFMOS transistor fabricated in BiCMOS 0.25μm technology from NXP Semiconductors. The results of matched RFMOS transistors at 30.5GHz are presented here and show good agreement between measurements/extractions and calculations (e.g. for C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">gs</sub> ). Second, a bipolar transistor matched test structure is investigated. An improvement of transmission gain of matched test structured from -12dB to -0.2dB has been found using measurements and simulated data.
Formation of equiaxed crystal structures in directionally solidified Al-Si alloys using Nb-based heterogeneous nuclei (2016)

The design of chemical compositions containing potent nuclei for the enhancement of heterogeneous nucleation in aluminium, especially cast alloys such as Al-Si alloys, is a matter of importance in order to achieve homogeneous properties in castings with complex geometries. We identified that Al<sub>3</sub>Nb/NbB<sub>2</sub> compounds are effective heterogeneous nuclei and are successfully produced in the form of Al-2Nb-xB (x = 0.5, 1 and 2) master alloys. Our study shows that the inoculation of Al-10Si braze alloy with these compounds effectively promotes the heterogeneous nucleation of primary α-Al crystals and reduces the undercooling needed for solidification to take place. Moreover, we present evidences that these Nb-based compounds prevent the growth of columnar crystals and permit to obtain, for the first time, fine and equiaxed crystals in directionally solidified Al-10Si braze alloy. As a consequence of the potent heterogeneous particles, the size of the α-Al crystals was found to be less dependent on the processing conditions, especially the thermal gradient. Finally, we also demonstrate that the enhanced nucleation leads to the refinement of secondary phases such as eutectic silicon and primary silicon particles.
A low level of TNF-α mediates hemorrhage-induced acute lung injury via p55 TNF receptor (2001)

Acute lung injury after hemorrhagic shock (HS) is associated with the expression of tumor necrosis factor (TNF)-alpha in the lung. However, the role of TNF-alpha and its receptors in this pulmonary disorder remains obscure. This study examined the temporal relationship of pulmonary TNF-alpha production to neutrophil accumulation during HS and determined the role of TNF-alpha in neutrophil accumulation and lung leak. HS was induced in mice by removal of 30% of total blood volume. Lung TNF-alpha was measured by ELISA. Neutrophil accumulation was detected by immunofluorescent staining, and microvascular permeability was assessed using Evans blue dye. Although HS induced a slight and transient increase in lung TNF-alpha, neutrophil accumulation preceded the increase in TNF-alpha. However, lung neutrophil accumulation and lung leak were abrogated in TNF-alpha knockout mice, and both were restored by administration of recombinant TNF-alpha to TNF-alpha knockout mice before HS. Neutrophil accumulation and lung leak were abrogated in mice lacking the p55 TNF-alpha receptor, but neither was influenced by p75 TNF-alpha receptor knockout. This study demonstrates that a low level of pulmonary TNF-alpha is sufficient to mediate HS-induced acute lung injury during HS and that the p55 TNF-alpha receptor plays a dominant role in regulating the pulmonary inflammatory response to HS.
Libra Subsea Achievements and Future Challenges (2019)

Abstract The paper uses a case study approach to present the challenges to develop a large and thick oil carbonate reservoir, full of opportunities but also of uncertainties. Additionally, Libra block development is under a Production Sharing Contract that was awarded to a Consortium where Petrobras is the operator in partnership with Shell, Total, CNOOC Limited and CNPC. This paper will present the main subsea technological achievements made during the execution of the Libra Extended Well Test (EWT) Project so far and also future technologies that will contribute to overcome the full field development challenges.
Is Older Colder or Colder Older? The Association of Age With Body Temperature in 18,630 Individuals (2011)

In animal studies, caloric restriction resulting in increased longevity is associated with a reduction in body temperature, which is strain specific and likely under genetic control. Small studies in humans have suggested that temperatures may be lower among elderly populations, usually attributed to loss of thermoregulation. We analyzed cross-sectional data from 18,630 white adults aged 20-98 years (mean 58.3 years) who underwent oral temperature measurement as part of a standardized health appraisal at a large U.S. health maintenance organization. Overall, women had higher mean temperatures (97.5 ± 1.2°F) than men (97.2 ± 1.1°F; p < .0001). Mean temperature decreased with age, with a difference of 0.3°F between oldest and youngest groups after controlling for sex, body mass index, and white blood cell count. The results are consistent with low body temperature as a biomarker for longevity. Prospective studies are needed to confirm whether this represents a survival advantage associated with lifetime low steady state temperature.
New Directional Electromagnetic Tool For Proactive Geosteering And Accurate Formation Evaluation While Drilling (2005)

A new logging-while-drilling (LWD) technology has been developed and field-tested, which introduces directional electromagnetic (EM) measurements through the use of tilted and transverse current-loop antennas. The multispacing and multifrequency directional measurements enable monitoring distance to formation boundaries and their orientation to facilitate proactive well placement. In combination with conventional LWD resistivity, these directional EM measurements allow for accurate structure and formation resistivity interpretation around the wellbore, independent of mud type. Furthermore, specific antenna combinations provide the capability to detect and characterize resistivity anisotropy in near-vertical wells while drilling. The directional EM tool is designed with a symmetrical transmitter-receiver configuration that optimizes the sensitivity to the desired formation parameters. While canceling the influence of anisotropy and formation dip, adding the symmetrical directional measurements together maximizes the sensitivity to bed boundaries, which is optimal for geosteering. The fact that the antennas are mounted on a conductive collar significantly reduces the large borehole effects that are normally associated with transverse EM measurements in conductive mud. In addition to exploring the physics of the new directional propagation measurements, we will demonstrate their unique applications with field test examples. By detecting and tracking, in real time, formation boundaries up to 15 ft around the wellbore, the directional propagation tool allows for sufficient time to make trajectory adjustments and stay within the reservoir. The bedding orientation information also answers the question, in what direction to steer, which is often ambiguous when relying on traditional propagation measurements. Particularly interesting applications are the placement of wells in thin oil rims and in reservoirs with complex structures such as intrabedded shale silts. Field test examples will also be shown of the enhanced formation evaluation capabilities offered by directional measurements in high-angle and horizontal wells, where formation resistivities can now be determined while accurately accounting for proximate bed boundaries. The ability to measure resistivity anisotropy in near vertical wells will be demonstrated by a field test example where the anisotropy measurement was confirmed by comparing with a conventional propagation resistivity measurement run in a near-by high-angle well.
Rat epididymis‐specific sperm maturation antigens. I. Evidence that the 26 kD 4E9 antigen found on rat caudal epididymal sperm tail is derived from a protein secreted by the epididymis (1994)

Monoclonal antibody 4E9, which was raised against a partially purified detergent extract of rat caudal epididymal sperm, recognizes the tail of sperm from the cauda, but not from caput epididymidis, as well as epithelial cells in a restricted region of the distal caput/corpus epididymidis and proteins in epididymal fluid from corpus and cauda epididymidis. The antigen is apparently a glycoprotein, since it is retained on a Ricinus communis agglutinin I lectin column. Epididymal fluid antigens have apparent M(rs) of 38-26 kD, whereas the membrane-associated form of the molecule has an M(r) of 26 kD. Immunocytochemical data and Western immunoblot data suggest that the membrane antigen is derived from the fluid antigen, which, in turn, is secreted by the epididymal epithelium. Characterization of the membrane antigen indicates that it is tightly associated with the sperm surface, behaving as though it is an integral membrane protein. The antigen persists on ejaculated sperm.
Nouvelles avancées en modélisation cinétique de la thermo-oxydation des matrices époxy-diamine (2016)

Le modèle cinétique mis au point pour décrire la thermo-oxydation de plusieurs substrats polyméthyléniques linéaires, dans des études antérieures menées au laboratoire PIMM, a été généralisé avec succès aux matrices époxy-diamine (EPO-DA) dans le cadre du projet de recherche « COMPosites Tièdes et INNovants » financé par le Fonds Unique Interministériel (FUI COMPTINN). Il est dérivé d’une réaction en chaîne radicalaire amorcée par décomposition des hydroperoxydes qui se propage par l’intermédiaire des liaisons C-H situées en α des hétéroatomes (O et N). De plus, il couple la diffusion d’oxygène et sa consommation chimique dans une équation bilan, donnant ainsi accès aux profils des évènements chimiques dans l’épaisseur des échantillons ainsi qu’à leur évolution au cours du temps. Les différents paramètres de ce modèle ont été identifiés avant de vérifier son pouvoir prédictif. D’une part, les propriétés de transport d’oxygène ont été compilées de la littérature ou déterminées par perméation d’oxygène au laboratoire. D’autre part, les constantes de vitesse et les rendements des actes chimiques élémentaires ont été déterminés par méthode inverse à partir d’essais de thermo-oxydation menés entre 0,21 et 20 bars d’oxygène et entre 120 et 200 ◦C sur des films minces de matrice TACTIX. Au final, le modèle prédit fidèlement les valeurs des critères de vieillissement rapportées dans la littérature pour les matrices EPO-DA ou mesurées dans le cadre de ce projet de recherche, comme la vitesse maximale d’oxydation, la pression d’oxygène critique ou l’épaisseur de la couche oxydée.
Scalable on-the-fly detection of the first races in parallel programs (1998)

Detecting races is important for debugging shared-memory parallel programs, because the races result in unintended nondeterministic executions of the programs. Most on-thefly techniques to detect the races cause the central bottlenecks of serializing all accesses of each thread to a shared variable. The amount of such bottlenecks can be reduced in case of detecting the first races that may cause the other races. This paper presents a new scalable on-the-fly technique which reduces the central bottlenecks to serializing at most two accesses of each thread to a shared variable for detecting the first races in parallel programs. It is important to detect the first races efficiently, because the removal of the Iirst races can make other races disappear.
Gossypol binds to a high‐affinity binding site on human serum albumin (1983)

The triterpene gossypol competes with bilirubin for a high-affinity binding site on human serum albumin. Similar competition between bilirubin and gossypol occurs in the binding of these ligands to the glutathione S-transferases from human liver and placenta. In each case, gossypol and bilirubin exhibit similar binding constants. The binding properties of gossypol may generally mimic those of bilirubin.
Integrated devices for advanced modulation formats (2004)

We describe the application of GaAs modulator integration within high performance transmitter modules for enhanced optical transmission using advanced modulation formats at 10 Gb/s and above.
Tris[4-(2-pyridylmethyleneamino)phenol]iron(II) bis(perchlorate) (2007)

In the title compound, [Fe(C(12)H(10)N(2)O)(3)](ClO(4))(2), the metal center is coordinated by six N atoms from the three bidentate chelating ligands in a distorted octa-hedral coordination geometry, with overall formation of the meridional (OC-6-21) isomer. Inter-molecular O-H⋯O hydrogen bonds between the hydroxyl groups of the cation and the counter-anions form an infinite one-dimensional chain in the c-axis direction.
More than a gut feeling - sonographic prenatal diagnosis of imperforate anus in a high-risk population (2014)

In a CAKUT population, absence of the AM in the posterior perineal triangle in the axial trans-perineal view emerges as an important sonographic marker for prenatal diagnosis of AA.
Integration of Material Flow Management Tools in Workplace Environments (2005)

This chapter describes how information technology (IT) support for industrial ecology can be integrated in a workplace environment, providing a homogeneous user interface and role-based access to information. The term “industrial ecology” comprises all activities of a company in regard to the natural environment. These can be, among others: operative tasks (e.g., handling of hazardous materials), compliance tasks (e.g., preparing declarations to be submitted to authorities), as well tasks involved in building up an environmental management system. It may also include innovative new approaches, such as “Design for Environment” or recycling oriented design. Other terms with a similar connotation are “cycle-oriented industry” or “integrated production”. To the user it is not really relevant which application furnishes the data he or she accesses. Rather, the user wants the data to be served in a harmonized way and adapted to his or her specific work context; the user wishes to use it in material flow models and he or she needs to utilize the data in cooperative work processes. Computer support and data aggregation are therefore only one aspect. Additionally it is required to work with adequate tools for creating and using material flow models as well as for supporting communication in business processes. The result is a “Business Package for Industrial Ecology”.
Synthesis of benzocyclobutenone containing polymers for UV curable pressure sensitive adhesive applications (2005)

Synthesis of novel benzocyclobutenone (BCBO) containing polymers provide for residual-free pressure sensitive adhesives (PSA's) that can be readily UV photo-crosslinked without the need for conventional photoinitiators.
Unsteady Surface Element Method (1981)

A method for the solution of transient heat conduction problems, called the unsteady surface element (USE) method, is developed and applied to several problems. The method is intended for thermally contacting bodies of similar or dissimilar geometries such as occur in contact conductance and intrinsic thermocouple problems. The method utilizes Duhamel’s integral in several ways. Two different procedures are presented, one utilizing temperature-based kernels and the other uses heat flux-based kernels. One of the given applications is to the intrinsic thermocouple problem. Several solutions are given and the results agree very well with two finite difference solutions.
Engine fault detection using angle domain signal envelope algorithm (2013)

Vibration signals from internal combustion engines contain strong noise and nonstationary characteristics in the time domain, which cause difficulties when attempting to detect and diagnose incipient faults in engines using signal features. In order to improve the success rate and broaden the applicability of engine incipient fault detection, a new concept of angle domain signal envelope analysis is proposed. The new method uses an encoder to acquire an engine rotational vibration signal using equal angle sampling. Angle domain synchronous averaging is used to denoise the original signal, and engine incipient fault features are extracted by the angle domain signal envelope algorithm. Experimental results using signals recorded from an engine with a connecting rod bearing with improper fit clearance have shown that the angle domain signal envelope algorithm can extract useful features from the vibration signal. The effectiveness of the new detection algorithm was verified. The engine fault detection method based on an angle domain signal envelope algorithm provides a new way to detect and diagnose engine incipient faults.
The Frustrated Host Response to Legionella pneumophila Is Bypassed by MyD88-Dependent Translation of Pro-inflammatory Cytokines (2014)

Many pathogens, particularly those that require their host for survival, have devised mechanisms to subvert the host immune response in order to survive and replicate intracellularly. Legionella pneumophila, the causative agent of Legionnaires' disease, promotes intracellular growth by translocating proteins into its host cytosol through its type IV protein secretion machinery. At least 5 of the bacterial translocated effectors interfere with the function of host cell elongation factors, blocking translation and causing the induction of a unique host cell transcriptional profile. In addition, L. pneumophila also interferes with translation initiation, by preventing cap-dependent translation in host cells. We demonstrate here that protein translation inhibition by L. pneumophila leads to a frustrated host MAP kinase response, where genes involved in the pathway are transcribed but fail to be translated due to the bacterium-induced protein synthesis inhibition. Surprisingly, few pro-inflammatory cytokines, such as IL-1α and IL-1β, bypass this inhibition and get synthesized in the presence of Legionella effectors. We show that the selective synthesis of these genes requires MyD88 signaling and takes place in both infected cells that harbor bacteria and neighboring bystander cells. Our findings offer a perspective of how host cells are able to cope with pathogen-encoded activities that disrupt normal cellular process and initiate a successful inflammatory response.