gebhart/patrepeval huggingface dataset:
Failure correction in time‐modulated linear arrays (2013)

A technique for failure correction in time‐modulated linear arrays is presented. Starting from the knowledge of the array elements with failures, the on–off behaviour of the switches at the other elements is properly reconfigured to radiate a pattern as close as possible to the ideal one in terms of pattern features. The array reconfiguration is carried out by solving an optimisation problem through the minimisation of a suitable cost function proportional to the mismatch between ideal and reconfigured pattern features. Representative results are reported and discussed to illustrate the effectiveness of the proposed approach as well as to assess the robustness to failures of time‐modulated arrays thanks to their real‐time reconfigurability.
Ligation of CD28 by Its Natural Ligand CD86 in the Absence of TCR Stimulation Induces Lipid Raft Polarization in Human CD4 T Cells (2005)

Stimulation of resting CD4 T cells with anti-CD3/CD28-coated beads leads to rapid polarization of lipid rafts (LRs). It has been postulated that a major role of costimulation is to facilitate LR aggregation. CD86 is up-regulated or expressed aberrantly on immune cells in a wide array of autoimmune and infectious diseases. Using an Ig fusion with the extracellular domain of CD86 (CD86Ig) bound to a magnetic bead or K562 cells expressing CD86, we demonstrated that ligation of CD28 by its natural ligand, but not by Ab, induced polarization of LRs at the cell-bead interface of fresh human CD4 T cells in the absence of TCR ligation. This correlated with activation of Vav-1, increase of the intracellular calcium concentration, and nuclear translocation of NF-kappaB p65, but did not result in T cell proliferation or cytokine production. These studies show, for the first time, that LR polarization can occur in the absence of TCR triggering, driven solely by the CD28/CD86 interaction. This result has implications for mechanisms of T cell activation. Abnormalities in this process may alter T and B cell tolerance and susceptibility to infection.
Site directed mutagenesis of DNA polymerase I (Klenow) from Escherichia coli (1993)

We have reported that a domain containing Arg682 in the Klenow fragment of Escherichia coli DNA polymerase I (pol I) is important for the template-dependent dNTP-binding function [Pandey, V.N., Kaushik, N. A., Pradhan, D. S. & Modak, M. J. (1990) J. Biol. Chem. 265, 3679-3884]. In order to further define the role of Arg682 in the catalytic process, we have performed site-directed mutagenesis of this residue. For this purpose the Klenow-coding region of the DNA-pol-I gene was selectively amplified from the genomic DNA of E. coli and was cloned in an expression vector, pET-3a. This clone under appropriate conditions overproduces the Klenow fragment in E. coli. Using this clone (pET-3a-K) as the template, two mutant polymerase clones were constructed in which arginine has been replaced with either alanine, [R682A] pol I, or lysine [R682K] pol I. Both mutant enzymes showed significantly lower specific activity as compared to the wild-type enzyme. The kinetic analyses of the mutant enzymes indicated a 3-4-fold increase in the Km for the substrate dNTP, a 20-25-fold decrease in the Vmax and an overall decrease in the processive nature of DNA synthesis in both the mutant enzymes. The reverse mutation of Ala682 to the wild-type form Arg682 fully restored the processive nature and the polymerase activity of the enzyme. These observations suggest that the positively charged guanidino group in the side chain of Arg682 is catalytically important but not absolutely essential for synthesis of DNA. Furthermore it appears to maintain high processivity of the DNA synthesis catalyzed by the enzyme.
Early Expression of Tumor Necrosis Factor α and Nuclear Factor Kappa B After Descemet Stripping Endothelial Keratoplasty in Rabbits (2012)

Rabbits with DSEK had a lower rejection rate than rabbits with PKP. NFκB and TNF-α may contribute to the early rejection of corneal allografts.
Partitioned posting files: a parallel inverted file structure for information retrieval (1989)

This paper describes algorithms and data structures for applying a parallel computer to information retrieval. Previous work has described an implementation based on overlap encoded signatures. That system was limited by 1) the necessity of keeping the signatures in primary memory, and 2) the difficulties involved in implementing document-term weighting. Overcoming these limitations requires adapting the inverted index techniques used on serial machines. The most obvious adaptation, also previously described, suffers from the fact that data must be sent between processors at query-time. Since interprocessor communication is generally slower than local computation, this suggests that an algorithm which does not perform such communication might be faster. This paper presents a data structure, called a partitioned posting file, in which the interprocessor communication takes place at database-construction time, so that no data movement is needed at query-time. Algorithms for constructing the data structure are also described. Performance characteristics and storage overhead are established by benchmarking against a synthetic database.
Theoretical and Experimental Investigations on Nonlinear Capacitance and Loading Effects on Power PHEMT's Linearity (2003)

This paper presents a theoretical and experimental analysis of the phase conversion phenomena in a power PHEMT transistor. Relationships between the linearity of the device and the intrinsic gate-source capacitance CGS, gate-drain capacitance CGD ,transconductance GM as well as the load impedance ZL ,are explained. A judicious choice of the transistor’s operating conditions allows to reduce thephaseconversion AM/PM. In the case of PHEMT devices, the behaviors of CGS,CGD,GM elements and ZL value induce internal compensation phenomena between the intrinsic non-linearities.
Contrasting Pathology of the Stress Granule Proteins TIA-1 and G3BP in Tauopathies (2012)

Stress induces aggregation of RNA-binding proteins to form inclusions, termed stress granules (SGs). Recent evidence suggests that SG proteins also colocalize with neuropathological structures, but whether this occurs in Alzheimer's disease is unknown. We examined the relationship between SG proteins and neuropathology in brain tissue from P301L Tau transgenic mice, as well as in cases of Alzheimer's disease and FTDP-17. The pattern of SG pathology differs dramatically based on the RNA-binding protein examined. SGs positive for T-cell intracellular antigen-1 (TIA-1) or tristetraprolin (TTP) initially do not colocalize with tau pathology, but then merge with tau inclusions as disease severity increases. In contrast, G3BP (ras GAP-binding protein) identifies a novel type of molecular pathology that shows increasing accumulation in neurons with increasing disease severity, but often is not associated with classic markers of tau pathology. TIA-1 and TTP both bind phospho-tau, and TIA-1 overexpression induces formation of inclusions containing phospho-tau. These data suggest that SG formation might stimulate tau pathophysiology. Thus, study of RNA-binding proteins and SG biology highlights novel pathways interacting with the pathophysiology of AD, providing potentially new avenues for identifying diseased neurons and potentially novel mechanisms regulating tau biology.
Novel and simplified passive intermodulation distortion measurement using vector network analyzer (2014)

This paper presents novel and simplified test setups for passive intermodulation (PIM) distortion measurement using vector network analyzer (VNA). The proposed test setups can provide certain automation with 57% test time reduction and instruments reduction for modern microwave test industry. 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> -order PIM distortion measurements for a GSM1800 frequency band cavity filter were implemented using 2-port, 4-port Agilent VNA and classic spectrum analyzer, respectively. Measurements comparisons are also implemented and discussed.
Testing a Web Application Involving Web Browser Interaction (2009)

Web applications become more and more complex. Thus, systematic approaches for Web application testing are needed. Existing methods take into consideration only those actions provided by the application itself and do not involve actions provided by the browser, such as the usage of backward and forward buttons. Base on existing testing techniques, this paper addresses an approach to discovering possible inconsistencies caused by interactions with Web browser buttons and the property of a Web page related to Web browser buttons. A navigation tree considering the role of the browser buttons while navigating a Web application is constructed. Three adequacy criteria based on user actions are presented for test case selection. For illustration, a simple inquiring balance system of a Web application is exemplified.
Effects of abstentions on voting procedures in three-candidate elections (1979)

This article deals with decision making in living systems at the levels of the organization, society, or supranational system. Abstention rates have a significant effect on the propensities of different voting procedures to elect the global Condorcet majority candidate in a three-candidate election when it exists. Hence any comparison of voting procedures that is concerned about the election of a global Condorcet candidate should reckon with abstention rates that may obtain for different procedures. Precise and approximate Condorcet propensities as functions of abstention rates are derived for the following voting rules for large electorates: Condorcet rules, including Black's rule; weighted scoring rules, including plurality and Borda rules; approval voting; and runoff elections in which a weighted scoring rule is used to eliminate one of the three candidates after the first ballot.
Supplementary materials and Supplementary Figures 1-9 from GnRH-R–Targeted Lytic Peptide Sensitizes <i>BRCA</i> Wild-type Ovarian Cancer to PARP Inhibition (2023)

&lt;p&gt;Supplementary Materials. Chemical structure and amino acid sequence of EP-100. Supplementary Figure S1. Expression and localization of GnRH-R in ovarian cancer cells. Supplementary Figure S2. The effects of GnRH-R loss on the cytotoxicity of EP-100. Supplementary Figure S3. Effects of doxorubicin, paclitaxel, olaparib, topotecan, and cisplatin on the viability of ovarian cancer cells. Supplementary Figure S4. Combined effects of EP-100 with doxorubicin, paclitaxel, topotecan and cisplatin on ovarian cancer cells. Supplementary Figure S5. Protein expressions as detected by RPPA assay. Supplementary Figure S6. The combined effect of treatment with EP-100 and olaparib in a subcutaneous mice model. Supplementary Figure S7 (related to Supplementary Figure S1 and Supplementary Figure S2). The original figures of the Western Blotting bands for GnRH-R expression. Supplementary Figure S8 (related to Figure 4A). Representative comets from comet assays. Supplementary Figure S9 (related to Figure 4C and D). Representative images from immunofluorescence assay.&lt;/p&gt;
4-N-pyridin-2-yl-benzamide nanotubes compatible with mouse stem cell and oral delivery inDrosophila (2010)

p-aminobenzoic acid (PABA), a structural moiety of many commercial drugs, is self-assembled with linker alkyl side chains to form tubular nanostructures. The tubes exhibited fluorescence either intrinsic or from fluorescent molecules embedded in the wall during self-assembly. Uptake and inter-cellular delivery of the conjugated nanotubes in human cancer cells and in mouse embryonic stem cells were demonstrated by fluorescence imaging and flow cytometry. Biocompatibility, cytotoxicity and clearance were monitored both ex vivo in mouse multipotent embryonic stem cells and in vivo in adult Drosophila. Accumulation of nanotubes had no adverse effects and abnormalities on stem cell morphology and proliferation rate. A distinct distribution of two separate nanotubes in various internal organs of Drosophila interprets that accumulation of nanomaterials might be interdependent on the side chain modifications and physiological settings of cell or tissue types. Unlike carbon nanomaterials, exposure of PABA nanotubes does not produce any hazards including locomotion defects and mortality of adult flies. Despite differential uptake and clearance from multiple live tissues, the use of self-assembled nanotubes can add new dimensions and scope to the development of dual-purpose oral carriers for the fulfilment of many biological promises.
Local Heat Increases Blood Flow and Oxygen Tension in Wounds (1987)

The effect of local hyperthermia on subcutaneous tissue oxygen tension (Psqo2) and perfusion was investigated in eight patients (13 trials) using a subcutaneously implanted oxygen tonometer. Application of heat increased subcutaneous tissue temperature and Psqo2. Mean Psqo2 during oxygen breathing rose by 39.5 mm Hg, an 80% increase over the average baseline Psqo2. The corresponding mean subcutaneous temperature increased 4.0 degrees C. A significant linear correlation was found between the change in Psqo2 and subcutaneous temperature. There was an average threefold increase in local perfusion estimated by using the Fick principle. The data reaffirm the value of local hyperthermia in treating contaminated wounds and suggest a mechanism for its ability to ameliorate infections. The mechanism implies that local heat may have prophylactic value as well.
Mutual coupling reduction between two closely spaced inverted-F antennas (2015)

Recent demands for miniaturized, lightweight, high data rate, and reliable wireless devices motivated researches and designers of wireless systems to adopt the use of multiple input-multiple output MIMO antenna arrays with close proximity of each other. One of the difficulties is to overcome the problems associated with the low isolation between any two closely spaced antennas. The low profile, small size, ease of fabrication, and simplicity of design encourage the use of the IFA/PIFA antennas. In this paper, two vertical IFA antennas with close separation of λ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</inf> /15 (<< λ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</inf> /2) fed by coaxial lines are combined in an array operating at the frequency of 2.5 GHz. The two antennas are deployed on a ground backed substrate of 50 mm × 50 mm in length and width respectively and a thickness of 1.524 mm with a relative permittivity, ε <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</inf> of 10.2. Each IFA consists of a monopole as the main radiator with a length of 38 mm and a diameter of 1.22 mm placed 11 mm above the ground plane. The separation between the feeding point and the grounded end of the radiating element is 10 mm. The consequence of positioning the antenna in the proximity of each other is the high mutual coupling. To decrease the resulted effects, a new Defected Ground Structure (DGS) has been proposed. A rectangular slot of 32 mm and width of 1.5 mm with a strip line of 29 mm in length and a width of 1 mm have been introduced to the ground plane. The final proposed array with the DGS is shown in the attached figure. The Defected Ground Structure (DGS) has the effect of reducing the interaction between the antennas, main radiators, by restricting the current flow in the ground plane. A parametric study has been carried out to obtain the optimum dimensions of the structure using Ansys High Frequency Structure Simulator (HFSS). The S-Parameters of the design are shown in the enclosed figure. The antenna has an operating frequency of 2.5 GHz. A total isolation level of -22 dB has been achieved by the proposed structure at the operating frequency. The array with the proposed ground structure provides a gain of 3.9 dB at 2.5 GHz when the two ports are excited. This structure is a good candidate for reducing the mutual coupling between two vertical IFA for application utilizing MIMO techniques.
Information Communication Technology Revolutionizing Tourism (2005)

This paper identifies a number of key changes in Information Communication Technologies (ICT) that gradually revolutionize the tourism industry. E-tourism and the Internet in particular support the interactivity between tourism enterprises and consumers and as a result they re-engineer the entire process of developing, managing and marketing tourism products and destinations. All stakeholders related to tourism and hospitality, therefore, gradually see their role being changed and new opportunities and challenges emerging. The paper demonstrates that future of e-Tourism will be focused on consumer centric technologies to ensure that the new sophisticated and experienced consumers are served. Therefore, agile strategies are required at both strategic and tactical management levels to develop the ‘info- structure’ for tourism organizations to manage their internal functions, their relationships with partners and their interactions with all stakeholders including consumers. Only those organizations that appreciate the opportunities which ICTs bring and manage their resources successfully will be able to enhance their innovation and competitiveness in the future.
Factors Influencing Recurrence after Surgical Treatment of Odontogenic Maxillary Sinusitis: An Analysis from the Oral and Maxillofacial Surgery Point of View (2023)

The aim of the study was to determine the factors influencing the development of recurrence after the surgical treatment of odontogenic maxillary sinusitis in an oral and maxillofacial surgery clinic over a 7-year period. Demographic and anamnesis data, clinical and radiological findings, treatment and outcome were analyzed. A multivariable analysis was performed to find associations between patient age, causative focus, surgical access for sinus revision, multilayer closure with a buccal fat pad, inferior meatal antrostomy (IMA) for temporary sinus drainage and sinusitis recurrence. A total of 164 patients with a mean age of 51.7 years were included. Sinusitis recurrence was observed in nine patients (5.48%) within 6 months after primary surgery. No significant correlation was detected between patient age, causative focus, surgical access for sinus revision, multilayer closure with a buccal fat pad, IMA for sinus drainage and the development of recurrence (<i>p</i> > 0.05). Patients with a history of antiresorptive-related osteonecrosis of the jaw showed a significant tendency toward disease recurrence (<i>p</i> = 0.0375). In conclusion, except for antiresorptive administration, none of the investigated variables were related to a higher risk of sinusitis recurrence. We encourage a combined approach of intraoral removal of the infective focus and sinus drainage via FESS, as well as an individual treatment decision in a multidisciplinary setting with collaboration between dentistry, maxillofacial surgery and otorhinolaryngology to avoid sinusitis recurrence.
Testing method of steering vibration based on human sensitivity (2018)

The steering vibrations include the useful information, such as road condition, for the drivers. Therefore, the various evaluations about relations of the steering vibration characteristics and the road information are carried out. In this paper, the human vibration sensitivities of the steering vibration concerned with the road information were evaluated first. It is clarified that the vibration direction of frequency band more than 20Hz can’t be discriminated and the sensitivity of the vibration power is decrease at an incline of 10dB/dec for frequency. Next, the evaluating method of the steering vibration using the steering simulator was examined based on the human vibration sensitivities. As a result, it was clarified that the steering vibration can be evaluated by the vibration combination of the rotational vibration and the translation vibration more than 20 Hz.
Sade eudémoniste: la quête du bonheur entre mouvement et repos (2018)

La figure du marquis de Sade est généralement exclue des différentes études qui reconstruisent l’histoire du bonheur en tant que concept philosophique.1 Cette omission semble être motivée par deux axes. Sur un plan général, Sade, comme tous les auteurs témoins de la mise en échec des valeurs des Lumières par la Révolution, est associé au déclin de l’eudémonisme qui caractérise le passage du dix-huitième au dix-neuvième siècle (le soi-disant tournant des Lumières), lorsque ‘l’idée du bonheur meurt en plusieurs manières, en suivant ou en anticipant l’épuisement des forces d’expansion de la modernité’.2 Sur un plan plus spécifique, cependant, l’œuvre du ‘divin marquis’ a souvent été rejetée comme une déformation pathologique de la réflexion sur le bonheur du dix-huitième siècle, jusqu’à être considérée, en conclusion, comme une forme d’anti-eudémonisme. Cette hypothèse sert de la base aux rares réflexions sur l’œuvre sadienne que l’on peut trouver dans L’Idée du bonheur dans la littérature et la pensée françaises au xviiie siècle par Robert Mauzi, la plus influente étude sur l’idée de félicité en France à l’âge classique.3
Conservation Science (2018)

Conservation science, also known as heritage science, is an interdisciplinary field that focuses on preserving artistic and cultural heritage objects and contributes to an understanding of their context. Characterizing individual materials and their deterioration yields knowledge of the structure and properties of a heritage object and, along with identifying degradation pathways, furthers development of conservation treatments. Research also determines the ideal environmental conditions for heritage objects, for example, appropriate relative humidity and temperature ranges and lighting conditions. Recommendations for appropriate materials for exhibiting, storing, and transporting objects as well as for use in conservation treatments are also based on conservation science research. Conservation scientists specialize in specific analytical techniques and apply expert knowledge of sampling, sample preparation, data interpretation, and the significance of the results for cultural heritage. These professionals work closely with others, for example conservators, archaeologists, art historians, and curators.