gebhart/patrepeval huggingface dataset:
A phase 1b open-label study to evaluate the safety and tolerability of MEDI4736, an anti–PD-L1 antibody, in combination with tremelimumab in subjects with advanced non–small cell lung cancer. (2014)

e19137^ Background: CTLA-4 and PD-L1 are critical, non-redundant, signals responsible for controlling T-cell activation. Clinical trials have shown the therapeutic utility of blocking each of these signals in order to enhance anti-tumor immunity in a proportion of patients. CTLA-4 and PD-L1 targeting agents show similar monotherapy activity in mice implanted with a Kras mutant cancer cell line. When used in combination in the same model, the 2 agents showed significant synergy, resulting in complete tumor regression in all mice treated. These observations suggest that combination therapy may generate greater antitumor activity compared with monotherapy in non–small cell lung cancer (NSCLC). The safety profile of MEDI4736 (M), an anti-PD-L1 antibody, in combination with tremelimumab (T), an anti-CTLA-4 antibody, is being explored using a 4-wk dosing interval in patients (pts) with NSCLC. Methods: This study is evaluating the safety, pharmacodynamics, and preliminary activity of M and T. The study is currently enrolling pts in the dose escalation phase using a 3+3 design. A subsequent dose expansion phase will include immunotherapy-naive and -pretreated cohorts. In addition, intermediate doses will be explored, depending on the observed safety and efficacy profile, using a modified zone-based design. Results: As of January 10, 2013, 3 pts have been treated in Cohort 1 (3 mg/kg [M] and 1 mg/kg [T]): age range is 72–78 years; pts had 1–3 prior treatments; 2 pts have adenocarcinoma, 1 has squamous cell carcinoma. After a follow-up of 8-10 wks, related adverse events include a grade 2 asymptomatic elevated amylase with no grade 3/4 or dose-limiting toxicities reported. Pharmacokinetic and pharmacodynamic data are being analyzed. Conclusions: The current safety profile supports continued dose escalation. The study will also assess pharmacokinetic and pharmacodynamic parameters, including serum and tissue PDL1, immune cell phenotypes, cytokine profiling, and flow. Pharmacogenomic analysis of blood and tumor samples may be performed to examine gene expression patterns at baseline versus changes in response to treatment. Clinical trial information: NCT02000947.
Adaptive Popularity Debiasing Aggregator for Graph Collaborative Filtering (2023)

The graph neural network-based collaborative filtering (CF) models user-item interactions as a bipartite graph and performs iterative aggregation to enhance performance. Unfortunately, the aggregation process may amplify the popularity bias, which impedes user engagement with niche (unpopular) items. While some efforts have studied the popularity bias in CF, they often focus on modifying loss functions, which can not fully address the popularity bias in GNN-based CF models. This is because the debiasing loss can be falsely backpropagated to non-target nodes during the backward pass of the aggregation.
COMMISSIONING OF THE SPARC PHOTO-INJECTOR ∗ (2006)

The SPARC project [1] is born to perform R&amp;amp;D activity headed to realize SASE-FEL experiments at 500nm and higher harmonic generation. The project foresees the real-ization of a high brightness photo-injector able to produce a 150 ÷ 200MeV electron beam to drive FEL process inside a dedicated 12m long undulator. The machine is going to be assembled at LNF and its final configuration is made up of an RF gun, driven by a Ti:Sa laser, injecting into three SLAC type accelerating sections. Nowadays we are work-ing in a photo-injector test phase, aiming to characterize the main hardware components and to investigate the behavior of the e-beam dynamics in the first meters of drift. To do this we utilize the emittance-meter, a home designed diag-nostic device placed just after the RF gun, able to move 1.2 meters along the longitudinal axis to measure beam param-eters. In this paper we report a more accurate description of the project, the status of the single systems constituting the machine and the most important results we obtained in the e-meter phase.
Emerging Connections: Classical and Quantum Optics (2017)

The blurring
Correlation Between Angle Parameters and Central Corneal Thickness in Fuchs Endothelial Corneal Dystrophy (2019)

Larger CCT was significantly associated with narrower anterior chamber angle width, but not with LV. We showed that the severity of FECD is associated with angle chamber morphology.
Identification of Renox, an NAD(P)H oxidase in kidney (2000)

Oxygen sensing is essential for homeostasis in all aerobic organisms, but its mechanism is poorly understood. Data suggest that a phagocytic-like NAD(P)H oxidase producing reactive oxygen species serves as a primary sensor for oxygen. We have characterized a source of superoxide anions in the kidney that we refer to as a renal NAD(P)H oxidase or Renox. Renox is homologous to gp91(phox) (91-kDa subunit of the phagocyte oxidase), the electron-transporting subunit of phagocytic NADPH oxidase, and contains all of the structural motifs considered essential for binding of heme, flavin, and nucleotide. In situ RNA hybridization revealed that renox is highly expressed at the site of erythropoietin production in the renal cortex, showing the greatest accumulation of renox mRNA in proximal convoluted tubule epithelial cells. NIH 3T3 fibroblasts overexpressing transfected Renox show increased production of superoxide and develop signs of cellular senescence. Our data suggest that Renox, as a renal source of reactive oxygen species, is a likely candidate for the oxygen sensor function regulating oxygen-dependent gene expression and may also have a role in the development of inflammatory processes in the kidney.
Improved risk estimates for carbon tetrachloride. Project status report and technical progress report (1997)

Carbon tetrachloride (CCl{sub 4}) has been used extensively within the Department of Energy (DOE) nuclear weapons facilities. High levels of CCl{sub 4} at these facilities represent a potential health hazard for workers conducting cleanup operations and for surrounding communities. The overall purpose of these studies is to improve the scientific basis for assessing the health risk associated with human exposure to CCl{sub 4}. Specifically, the authors will determine the toxicokinetics of inhaled and ingested CCl{sub 4} in F344/Crl rats. B6C3F{sub 1} mice, and Syrian hamsters. They will also evaluate species differences in the metabolism of CCl{sub 4} by rats, mice, hamsters, and man. Dose-response relationships will be determined in all these studies. This information will be used to improve the physiologically based pharmacokinetic (PBPK) model for CCl{sub 4} originally developed by Paustenbach et al. (1988) and more recently revised by Thrall and Kenny (1996). The authors will also provide scientific evidence that CCl{sub 4}, like chloroform, is a hepatocarcinogen only when exposure results in cell damage, cell killing, and regenerative cell proliferation.
A fragment of Dictyostelium discoideum genomic DNA that complements the URA1 mutation of Saccharomyces cerivisiae. (1982)

A strain of Saccharomyces cerivisiae carrying a mutation in the URA1 gene was transformed with fragments of Dictyostelium DNA inserted into a plasmid capable of replication in E. coli or yeast. Rare prototrophic colonies were recovered that all contained the parent plasmid and an insert of Dictyostelium DNA. Resistance to the antibiotic G418, a function coded by the same plasmid, was also expressed in the prototrophs. Plasmids recovered from the prototrophic yeast could be used to transform E. coli. The E. coli transformants harbored plasmids capable of transforming yeast URA1 mutants to prototrophy. No complementation of the E. coli pyrD mutation, which corresponds to URA1, occurred. Southern blot analysis revealed that the insert of Dictyostelium DNA contained a unique sequence of 1700 base pairs and a repetitive one of 1000 base pairs. Subcloning experiments showed that only the unique sequence was required for complementation, which is independent of the orientation of the Dictyostelium sequence in the plasmid. The repetitive fragment was not linked to the unique sequence in the genome and was probably an artifact of the ligation procedure. The unique sequence hybridized to a Dictyostelium polyA+ RNA species of 1200-1300 bases.
Diversity of genetic backgrounds modulating the durability of a major resistance gene. Analysis of a core collection of pepper landraces resistant to P otato virus Y (2015)

The evolution of resistance-breaking capacity in pathogen populations has been shown to depend on the plant genetic background surrounding the resistance genes. We evaluated a core collection of pepper (Capsicum annuum) landraces, representing the worldwide genetic diversity, for its ability to modulate the breakdown frequency by Potato virus Y of major resistance alleles at the pvr2 locus encoding the eukaryotic initiation factor 4E (eIF4E). Depending on the pepper landrace, the breakdown frequency of a given resistance allele varied from 0% to 52.5%, attesting to their diversity and the availability of genetic backgrounds favourable to resistance durability in the plant germplasm. The mutations in the virus genome involved in resistance breakdown also differed between plant genotypes, indicating differential selection effects exerted on the virus population by the different genetic backgrounds. The breakdown frequency was positively correlated with the level of virus accumulation, confirming the impact of quantitative resistance loci on resistance durability. Among these loci, pvr6, encoding an isoform of eIF4E, was associated with a major effect on virus accumulation and on the breakdown frequency of the pvr2-mediated resistance. This exploration of plant genetic diversity delivered new resources for the control of pathogen evolution and the increase in resistance durability.
Cellular Imaging with High-Performance Two-Photon Absorbing Fluorescent Contrast Agents (2006)

A new series of high-performing two-photon absorbing fluorescent contrast agents for cellular imaging were prepared. The spectral properties of these photostable, highly fluorescent, fluorophores, along with two- photon fluorescence imaging of live cells are presented.
Design of Self-adaptive Damping Controller to Low Frequency Power Oscillation in Interconnected Power Systems Based on Variable Frequency Transformer (2011)

Variable frequency transformer(VFT) is a new type of flexible AC transmission systems(FACTS) device for interconnecting power systems asynchronously.In this paper,the basic structure and functions of VFT were introduced,the performance of VFT to damp low frequency power oscillation was studied,and a new type of self-adaptive damping controller including system model and calculation program was developed by means of VFT and Prony method.Two simulation systems respective for a typical 4 generators power system and a complex practical power system with VFT devices were build up by means of power system analysis software package(PSASP),and the adaptivity and efficiency of self-adaptive damping controller were tested and verified with carefully studied under different conditions.
Detecting news reporting using audio/visual information (2003)

This paper proposes an integrated approach to discriminate news reporting from everything else in broadcast news data based on both audio and visual information. The separation of news reporting segments from others not only can provide useful indices for video streams but also serves as a pre-processing step for tasks such as speaker identification and speech recognition so that only speech segments are passed on for further processing. A set of audio and visual features are adopted that aim at capturing the intrinsic properties of the underlying classes. Four types of classifiers (threshold fuzzy, Gaussian Mixture Model based, and Support Vector Machine) are tested. Some of the experimental results are presented and discussed in the paper.
Can Animal Skin Diseases or Current Transgenic Mice Serve as a Model for Hidradenitis Suppurativa? (2012)

The pathogenesis of hidradenitis suppurativa (HS) is still enigmatic, and a valid animal model for HS is currently not available. The recent discovery of γ-secretase mutations in a subpopulation of patients with HS suggested γ-secretase transgenic mice as a model for HS pathogenesis. However, the discrepancies between human HS and these mice are daunting. We critically review cases of animal HS and transgenic γ-secretase mouse models for HS and discuss the criteria which should be met for a representative pathogenic model.
Adsorption of Aqueous Nucleobases, Nucleosides, and Nucleotides on Compost-Derived Humic Acid. 2. Naturally Occurring Purines (1996)

This paper describes adsorption of the aqueous purines adenine (10), adenosine (11), adenosine 5‘-monophosphate (12), guanosine (13), and guanosine 5‘-monophosphate (14) on compost-derived humic acid (HA) over the solute concentration (12−1200 μM) and temperature (10.0−40.0 °C) ranges used with pyrimidine solutes in Part 1. Nucleobase 10 and nucleosides 11 and 13 are neutral under the experimental conditions, while nucleotides 12 and 14 are monoanions. All the purines interact with HA, but only adenine causes HA dissolution at pH 5−6 and temperatures above 25.0 °C, as found with cytosine and (−)nicotine. The IR spectrum of the soluble adenine−HA product indicates strong interaction with carboxylic and phenolic HA groups that is not due to simple proton transfer. Pyrimidines and purines are adsorbed in sequence on three HA sites A, B, and C. Most of the data fit the Langmuir model to generate site capacities vA, vB and vC and equilibrium constants KA, KB, and KC for each solute and site. Average site capacities increase 〈vA〉 < 〈vB〉 < 〈vC〉, while equilibrium constants at 25.0 °C decrease KA > KB > KC. Site capacities vi are independent of temperature and solute molar mass or charge, indicating adsorption through solute nucleobase units. Adenine has unusually high average 〈vA〉 and 〈vB〉 related to its ability to dissolve HA at pH 6, but 〈vC〉 is unexceptional. The equilibrium constant data show that compost-derived HA sites have quite different solute selectivities. For example, site A discriminates poorly between the solutes thymine (4), thymidine (5), and 11 while site C has a strong preference for 4. These selectivities could influence animal, plant, soil, and sediment biochemistry. Linear correlation of the enthalpies and entropies for adsorption of every solute at each HA site points to a common underlying adsorption mechanism.
A search based approach to entity recognition (2014)

ERD 2014 was a research challenge focused on the task of recognition and disambiguation of knowledge base entities in short and long texts. This write-up describes Magnetic-IISAS team's approach to the entity recognition in search queries with which we have participated in ERD 2014 challenge. Our approach combines techniques of information retrieval, gazetteer based annotation and entity link graph analysis to identify and disambiguate candidate entities. We built a search index with multiple structured fields extracted from Wikipedia, Freebase and DBPedia. When processing a query, we first retrieve top matching entities from the index. For all retrieved entities, we gather plausible verbalizations, surface forms, that retrieved entities may be referred to with. We match gathered entity surface forms against the original query to confirm the entity relevance to the query. Finally, we exploit Wikipedia link graph to asses the similarity of candidate entities for the purpose of disambiguation and further candidate filtering. In the paper we discuss successful as well as unsuccessful attempts to improve the quality of system results that we have tried during the course of the challenge.
Lesson of the Week: Near fatal chickenpox during prednisolone treatment (1994)

The incidence of chickenpox (varicella) is increasing; thus, the proportion of cases in England and Wales in those over 14 years of age has increased from 10% to 25% between 1970 and 1990.1 Although usually mild among children, varicella is often severe and occasionally life threatening in adults, particularly in those whose immune systems have been suppressed by disease or treatment with corticosteroids.2,3 Corticosteroids are widely prescribed: over 5.5 million prescriptions for systemic corticosteroids were issued by general practitioners in the United Kingdom for the year ending September 1993 (Intercontinental Medical Statistics, personal communication). We describe a case of severe chickenpox in a patient being treated with high dose corticosteroids and put forward recommendations to reduce the risk of further cases.

Patients taking corticosteroids who are susceptible to chickenpox must receive immediate prophylaxis on contact with varicella; the steroid card should be amended

### Case report

We admitted a 27 year old woman with a 36 hour history of severe lower back pain. She had been taking steroids for six weeks; she started taking prednisolone 60 mg daily for idiopathic thrombocytopenia, but for the two weeks before admission she had been taking 30 mg daily. Twenty four hours after admission she developed a fever of 37.8°C and a maculopapular eruption with vesicles over the neck and shoulders. Vesicular fluid contained herpes virus particles, and we confirmed varicella zoster virus by immunofluorescence. The patient had not had chickenpox before, but she had been in contact with fellow students from her college, where there had been a number of recent cases.

We started treatment with …
8TH INTERNATIONAL PAPER AND COATING CHEMISTRY SYMPOSIUM 2012: The use of fluorescence microscopy and image analysis to characterize the porous structure in micro fibrillar cellulose gel – Part I: Brownian motion (2013)

Article 8TH INTERNATIONAL PAPER AND COATING CHEMISTRY SYMPOSIUM 2012: The use of fluorescence microscopy and image analysis to characterize the porous structure in micro fibrillar cellulose gel – Part I: Brownian motion was published on May 1, 2013 in the journal Nordic Pulp & Paper Research Journal (volume 28, issue 2).
Issues in Practice (1984)

In our paper we examine the seeming reluctance to discuss in any depth the issues implicit in the practice of Management Education and Development. We ask whether this is a case of myopia or phobia. The paper serves as an introduction to the overall theme of this special issue.
DNA sequence representation without degeneracy (2003)

Graphical representation of DNA sequence provides a simple way of viewing, sorting and comparing various gene structures. A new two-dimensional graphical representation method using a two- quadrant Cartesian coordinates system has been derived for mathematical denotation of DNA sequence. The two-dimensional graphic representation resolves sequences' degeneracy and is mathematically proven to eliminate circuit formation. Given x-projection and y-projection of any point on the graphical representation, the number of A, G, C and T from the beginning of the sequence to that point could be found. Compared with previous methods, this graphical representation is more in-line with the conventional recognition of linear sequences by molecular biologists, and also provides a metaphor in two dimensions for local and global DNA sequence comparison.
ECONOMIC GROWTH AND ENVIRONMENTAL DEGRADATION IN CANADA: AN EMPIRICAL ANALYSIS OF THE ENVIRONMENTAL KUZNETS CURVE (2010)

The Environmental Kuznets Curve (EKC) hypothesis postulates an inverted U-shaped relationship between measures of environmental degradation and per capita income. This paper empirically tests the validity of the EKC hypothesis in Canada for per capita emissions of green house gases (GHG), CO2, NOX, SOX, CO, and total particulate matter (TPM) emissions. The regression equations estimated are quadratic and cubic functions of per capita GDP. The type of data used are provincial and territorial level cross-sectional panel data and country level time-series data. The study finds that per capita emissions of GHG and CO exhibit inverted-U relationships with per capita GDP. In contrast, per capita SOX and TPM emissions follow a U-shape curve, In addition, per capita CO2 emissions may follow either an inverted U or an N shape curve. Furthermore, this study finds insufficient empirical evidence of an EKC for per capita NOX emissions.
REVIEW: From nociception to pain perception: imaging the spinal and supraspinal pathways (2005)

Functional imaging techniques have allowed researchers to look within the brain, and revealed the cortical representation of pain. Initial experiments, performed in the early 1990s, revolutionized pain research, as they demonstrated that pain was not processed in a single cortical area, but in several distributed brain regions. Over the last decade, the roles of these pain centres have been investigated and a clearer picture has emerged of the medial and lateral pain system. In this brief article, we review the imaging literature to date that has allowed these advances to be made, and examine the new frontiers for pain imaging research: imaging the brainstem and other structures involved in the descending control of pain; functional and anatomical connectivity studies of pain processing brain regions; imaging models of neuropathic pain-like states; and going beyond the brain to image spinal function. The ultimate goal of such research is to take these new techniques into the clinic, to investigate and provide new remedies for chronic pain sufferers.
Eltropuls-Plasmanitrieren, ein neues Verfahren der Wärmebehandlungstechnik (1983)

Article Eltropuls-Plasmanitrieren, ein neues Verfahren der Wärmebehandlungstechnik was published on December 1, 1983 in the journal Zeitschrift für wirtschaftlichen Fabrikbetrieb (volume 78, issue 12).
Boosting photonic quantum computation with moderate nonlinearity (2021)

We present a new pathway towards fault-tolerant photonic quantum computing by using moderate nonlinearity to improve elementary computation operations. This improvement can lead to a three orders-of-magnitude reduction of the resource overhead in large-scale computations.
Orientational epitaxy of a wall near the commensurate-incommensurate phase transition (1982)

The authors consider a physisorbed monolayer of rare gas atoms on graphite near the commensurate-incommensurate (C-I) phase transition. They calculate the energy associated with a small rotation of a wall, to second order in the rotation angle. The wall will be titled with respect to the symmetry axis of the substrate if the two-dimensional compressibility K-1 and the shear modulus mu satisfy K<or approximately=3.8 mu . This condition corresponds to non-central forces between adatoms, and therefore is not fulfilled by the rare gas interatomic interaction. They conclude that the walls created at the C-I transition are not rotated, and that rotation should take place in the I phase.