gebhart/patrepeval huggingface dataset:
Analysis of Pathogen Destruction and Leachate Constituents in Deer Mortality Static Windrow Composting (2013)

Approximately 1.1 million deer-vehicle collisions occur in the United States each year. The predominant methods of disposing of these carcasses (landfill and burial) have several costly disadvantages, including long travel distances to landfills, increasing landfill restrictions, and lack of viable burial areas. Some states have found static compost windrows to be an easy and cost-effective carcass management technique. In this study, deer mortality static compost windrows were monitored for 1 year. Windrows were analyzed for pathogen destruction and the degree to which underlying soil filtered leachate contaminants. In response to high windrow temperatures, indicator pathogens E. coli and Salmonella were reduced by 99.99% the first sampling day (Day 7) and ascarids were deemed non-viable by Day 77. Soil filtration of leachate was effective in reducing concentrations of ammonia, chloride, and total organic carbon. Nitrate, a contaminant of particular regulatory concern, had an estimated mass contaminant loss of 1.9 lb/acre, compared to the estimated 8 to 45 lb/acre loss from fertilizer application on agronomic crops in Virginia. Results of this study indicate that with properly constructed static compost windrows, (1) high temperatures destroy indicator pathogens; (2) the natural filtration of leachate through soil reduces deer mortality contaminant concentrations; and (3) the low volume of leachate from windrows results in nominal losses of nitrate and other contaminants. These results will be useful for compost regulators and entities interested in incorporating this practice into regular operations.
A Study of the Adhesion of Electrophoretically Deposited Phosphors (1998)

In the manufacturing of screens for advanced displays, layers of small (1 to 10 μm diam) luminescent particles may be deposited by electrophoretic deposition (EPD). A set of processing variables that enhance the adhesion strength of EPD phosphor deposits has been determined. Postdeposition baking at 425°C for 1 h, addition of water or glycerin and use of instead of in the deposition bath, and control of the particle size distribution can each enhance the adhesion strength of EPD phosphor deposits. When screens were excited by electron bombardment, the chromaticity was unchanged and the brightness was only slightly reduced by these processing conditions.
Synthesis of Nonreducing-sugar Subunit Analogs of Bacterial Lipid A Carrying the Acyloxyacyl Group of Different Carbon Chain Length (1990)

Journal Article Synthesis of Nonreducing-sugar Subunit Analogs of Bacterial Lipid A Carrying the Acyloxyacyl Group of Different Carbon Chain Length Get access Yuji Ogawa, Yuji Ogawa Department of Applied Bioorganic Chemistry, Gifu University, Gifu 501-11, Japan Search for other works by this author on: Oxford Academic Google Scholar Motoji Wakida, Motoji Wakida Department of Applied Bioorganic Chemistry, Gifu University, Gifu 501-11, Japan Search for other works by this author on: Oxford Academic Google Scholar Hideharu Ishida, Hideharu Ishida Department of Applied Bioorganic Chemistry, Gifu University, Gifu 501-11, Japan Search for other works by this author on: Oxford Academic Google Scholar Makoto Kiso, Makoto Kiso Department of Applied Bioorganic Chemistry, Gifu University, Gifu 501-11, Japan Search for other works by this author on: Oxford Academic Google Scholar Akira Hasegawa Akira Hasegawa Department of Applied Bioorganic Chemistry, Gifu University, Gifu 501-11, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 54, Issue 12, 1 December 1990, Pages 3251–3258, https://doi.org/10.1080/00021369.1990.10870454 Published: 01 December 1990 Article history Received: 18 June 1990 Published: 01 December 1990
Converged quantum dynamics calculations for the F+H2 reaction on the well-studied M5 potential-energy surface (1989)

We present converged quantum dynamics calculations for the reaction F+H2(vi=0)→HF(vf=0,1,2,3)+H, where vi and vf denote initial and final vibrational quantum numbers, on potential-energy surface no. 5 of Muckerman.
Synthese des Mastzellen-degranulierenden (MCD-)Peptides aus Bienengift (1979)

Sehr wertvoll zur Therapie der Volkskrankheit Rheumatismus und anderer Entzündungsvorgänge könnte das MCD-Peptid aus Bienengift sein, wenn dieser Stoff in größeren Mengen zur Verfügung stünde. Das Peptid besteht aus 22 Aminosäuren und enthält zwei Disulfidbrücken. Jetzt gelang die erste Totalsynthese.
Diagnosing New York city's noises with ubiquitous data (2014)

Many cities suffer from noise pollution, which compromises people's working efficiency and even mental health. New York City (NYC) has opened a platform, entitled 311, to allow people to complain about the city's issues by using a mobile app or making a phone call; noise is the third largest category of complaints in the 311 data. As each complaint about noises is associated with a location, a time stamp, and a fine-grained noise category, such as "Loud Music" or "Construction", the data is actually a result of "human as a sensor" and "crowd sensing", containing rich human intelligence that can help diagnose urban noises. In this paper we infer the fine-grained noise situation (consisting of a noise pollution indicator and the composition of noises) of different times of day for each region of NYC, by using the 311 complaint data together with social media, road network data, and Points of Interests (POIs). We model the noise situation of NYC with a three dimension tensor, where the three dimensions stand for regions, noise categories, and time slots, respectively. Supplementing the missing entries of the tensor through a context-aware tensor decomposition approach, we recover the noise situation throughout NYC. The information can inform people and officials' decision making. We evaluate our method with four real datasets, verifying the advantages of our method beyond four baselines, such as the interpolation-based approach.
Mission Performance Assessment of Multimode Propulsion for Satellite Servicing Applications (2022)

We assess the mission performance of a multimode (monopropellant-electrospray dual-mode) propulsion system relative to current state-of-the-art chemical, electric, and hybrid chemical-electric propulsion systems for satellite servicing applications. Performance is assessed for both low-Earth orbit servicers (with total mass of approximately 100 kg) and geosyn-chronous orbit servicers (with total mass of approximately 1000 kg). First-order spacecraft sizing routines are developed to determine spacecraft properties for each propulsion system option based on historical data, propulsion system properties, and physical and geometric constraints. The overall servicing missions are decomposed into a set of discrete maneuvers for both servicer concepts. Simulations are developed for each ma-neuver and propulsion system to determine flight performance, including &#x0394;V and time of flight. Finally, metrics of comparison between the different propulsion system options are proposed to illustrate the strengths and weaknesses of each propulsion system option over the candidate mission scenarios. Mission scenarios are composed of admissible sequences of modeled maneuvers. Comparison metrics are then used to highlight the costs and benefits of the assessed propulsion system options relative to each other. Results indicate that the hybrid and multimode systems provide significant mission flexibility for satellite servicing applications, but the multimode does so with a significantly lower structural ratio.
Molecular identification and antifungal susceptibility of clinical fungal isolates from onychomycosis (uncommon and emerging species) (2018)

Onychomycosis is a common nail problem, accounting for up to 50% of all nail diseases. The aim of the present study was to determine the species distribution based on the restriction fragment length polymorphism and susceptibility patterns of the causative agents of onychomycosis. This cross-sectional study was conducted on nail samples collected from 257 patients suspected of onychomycosis during 14 months. Fungal isolates were identified by polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) with the enzymes Msp I, Mva I, Alw I and sequencing. According to the results, out of the 257 patients participating in the study, onychomycosis was diagnosed in 180 (70.03%) cases, among which 51.1% were caused by non-dermatophyte moulds (NDMs), 35% by yeast and 10.6% by dermatophytes. Numerous cryptic species recovered from onychomycosis for the first time. In the majority of cases, novel triazoles and imidazoles (ie, efinaconazole, luliconazole and lanoconazole) showed potent activity in comparison with other antifungal agents. The minimum inhibitory concentration (MIC) of luliconazole and lanoconazole ranged within 0.001 to >1 μg/mL and their geometric mean MICs were 0.0154 and 0.0309 μg/mL against all isolates, respectively. It seems that obtained data will be useful to improve the knowledge of researchers, clinicians and dermatologists about onychomycosis distribution, species diversity and adoption of appropriate treatment.
Fugitive Propositions (1950)

Journal Article Fugitive Propositions Get access Patrick Nowell Smith Patrick Nowell Smith Trinity CollegeOxford Search for other works by this author on: Oxford Academic Google Scholar Analysis, Volume 10, Issue 5, April 1950, Pages 100–103, https://doi.org/10.1093/analys/10.5.100 Published: 01 April 1950
The effects of selenium on glutathione peroxidase activity and radioprotection in mammalian cells (1995)

The media of representative mammalian cell lines were supplemented with low levels of selenium in the form of sodium selenite in order to investigate the effects of selenium on mammalian cells. Following incubation in 30 nM sodium selenite, these cells were assayed for changes in glutathione peroxidase (GPx) activity. The cells examined included NIH 3T3 mouse fibroblasts, PC12 rat sympathetic precursor cells, SupT-1 human lymphocytes, MCF-7{sup adr} human breast carcinoma cells and AA8 Chinese hamster ovary cells. Selenium supplementation resulted in a marginal increase in GPx activity for the NIH 3T3, MCF-7{sup adr} and Supt-1 cells but stimulated GPx activity approximately 5-fold in PC12 and AA8 cells. AA8 cells were selected to evaluate whether selenium supplementation was radioprotective against {sup 60}cobalt gamma irradiation. Protection against radiation-induced mutation was measured by evaluating mutation frequency at the hprt locus. In this assay, preincubation of AA8 CHO cells significantly protected these cells from exposure to 8 Gy.
Long-term effect of anticoagulation following left atrial appendage occlusion with the LARIAT device in patients with nonvalvular atrial fibrillation: impact on thromboembolism, bleeding and mortality. Real life data (2020)

There is no need for OAC after the LAAO procedure. Omitting OAC after an LAAO procedure in AF patients: (1) has similar stroke prevention rates as patients on OAC, (2) has similar bleeding prevention rates as patients on OAC, (3) has similar safety endpoints and long-term efficacy as patients on OAC.
Erratum: Hansen, Lund, Sangill, and Jespersen. Experimentally and Computationally Fast Method for Estimation of a Mean Kurtosis. Magnetic Resonance in Medicine 69:1754–1760 (2013) (2014)

This erratum corrects a misprint in the original article. The correct equation was used in all the analysis, and, therefore, the misprint has no influence on the results or conclusions. In the Supplementary Information, which is available online, the reference to Eq. [12] immediately below Eq. [A14], should instead be a reference to Eq. [13].
Entdeckung konstanter und fluktuierender Echos im Rauschen (2002)

ZusammenfassungIn diesem Kapitel wird einleitend das Prinzip des automatischen Zieldetektors erläutert, das auf dem Neyman-Pearson-Test der Statistik beruht. Dieser Test liefert später auch die Begründung für den allgemeinen Entwurf eines Matched Filters. Die Funktion eines CFAR-Detektors wird nur kurz beschrieben, wegen seiner Bedeutung ist ihm das nachfolgende Kapitel 9 gewidmet.
Sleep-related breathing and sleep-wake disturbances in ischemic stroke (2009)

Sleep-related breathing disturbances and sleep-wake disturbances are frequent conditions that affect stroke outcome. In view of existing treatment options, these conditions deserve the neurologist's awareness.
Dépression, coping et qualité de vie dans la maladie de Parkinson. À propos de 50 patients tunisiens (2010)

ObjectifEvaluer la frequence de la depression et sa correlation avec le coping et la qualite de vie (QdV) chez une population de patients tunisiens atteints de la maladie de Parkinson (MP).Patients et methodeNous avons realise une etude transversale portant sur 50 patients atteints de la MP. L’evaluation de la QdV, de la depression et des strategies de coping a ete realisee respectivement a l’aide d’une version arabisee de l’echelle SF-36, l’echelle MDRS et le Brief-COPE test.Resultats et conclusionsLa depression a ete retrouvee chez 58 % des parkinsoniens. Les strategies de coping les plus utilisees etaient centrees sur l’emotion, en particulier la religion (54 %). L’alteration de la QdV interessait particulierement la limitation emotionnelle (98,6 %) et l’activite physique (60,7 %). La presence d’une depression et l’utilisation d’un coping emotionnel sont associees a une mauvaise QdV et doivent etre considerees dans la prise en charge somato-psychique des patients Tunisiens atteints de la MP.
Studies on the mechanism of desensitization of the parathyroid hormone-stimulated calcium signal in UMR-106 cells: Reversal of desensitization by alkaline phosphatase but not by protein kinase C downregulation (1994)

The involvement of protein kinase C (PKC), cAMP-dependent protein kinase (PKA), and other phosphorylation mechanisms in the rapid desensitization of the [Ca2+]i response to parathyroid hormone (PTH) stimulation was investigated in osteoblast-like UMR-106 cells. A 5 minute preincubation of the cell suspension with phorbol 12,13-dibutyrate (PDB) decreased the response to PTH in a concentration-dependent manner. 1-Oleoyl-2-acetyl-r-glycerol (OAG) pretreatment likewise decreased the PTH response. Staurosporine, a potent protein kinase inhibitor, completely prevented the desensitization caused by PDB. These PDB and staurosporine effects were also observed in 3 mM EGTA-containing medium ([Ca2+]free < 10(-8) M). A 5 minute pretreatment of cells with 1 microM forskolin had no effect on the calcium response to PTH. Homologous and PDB-induced desensitizations differed in several respects. Staurosporine pretreatment resulted in only a slight restoration of the PTH response under conditions of homologous desensitization. Chronic treatment with phorbol ester prevented the desensitization of the PTH response by acute phorbol treatment but not the homologous desensitization. Both homologous and PDB-induced desensitization were relieved by alkaline phosphatase treatment, consistent with the involvement of phosphorylation in the desensitization. This alkaline phosphatase effect on desensitization was inhibited by L-phenylalanine. These results suggest that PTH receptor homologous desensitization involves phosphorylation process(es) other than or in addition to those of PKC.
An Efficient Medium Access Control Protocol for under water Acoustic Sensor Network (2011)

a terrestrial wireless communication which uses radio waves, underwater communication relies on acoustic waves. The long latency and limited bandwidth pose great challenges in Underwater Media Access Control (MAC) design. So this paper proposes a new MAC protocol for wireless sensor acoustic network which are adaptable to underwater environment. This new protocol is based on the classic MACA to avoid hidden and exposed node problem. It also address the fragmentation issue, instead of sending a large packet it proposes to send fragmented packets to improve the throughput of the network. It introduces a new binary exponential back-off mechanism to reduce the possibilities of collision and hence to improve the throughput. The simulation result of the proposed protocol shows that its performance is better than the other MAC protocol. The simplicity and throughput stability of proposed MAC make it an appropriate reference MAC protocol.
Abstract A64: Human epidermal growth factor receptor 2 (HER2) directly binds and activates focal adhesion kinase (FAK) to promote oncogenesis (2015)

Abstract Introduction: Human epidermal growth factor receptor 2 (HER2) is known to require focal adhesion kinase (FAK) for cellular transformation, tumor growth, invasion, and metastasis. FAK is overexpressed in nearly all types of human cancer, serving as a molecular scaffold protein to integrate oncogenic growth factor receptors with focal adhesion proteins. We have identified a novel direct protein-protein interaction between HER2 and FAK. In this study, we investigated whether the HER2-FAK direct interaction is required for HER2-dependent oncogenesis and its potential as a novel drug target. Methods: We have taken a multidisciplinary approach (biophysics, biochemistry, molecular modeling, structural biology, and molecular biology) to map the HER2-FAK binding interface and to study the functional aspects of the interaction. Results: Our data indicated that the N-lobe of the HER2 kinase domain directly interacts with the F1 lobe of the FAK FERM domain. In addition, molecular modeling studies have identified a putative HER2-FAK interface suitable for the binding of small molecule inhibitors. Site-directed mutagenesis studies validated this binding interface. Functional data indicated that HER2 directly transphosphorylated FAK at key tyrosine residues, Y397, Y861, and Y925, irrespective of FAK kinase activity. Additionally, kinome reprogramming analysis revealed upregulation of HER2 signaling and maintenance of FAK phosphorylation after FAK-kinase inhibitor treatment. Finally, cellular data suggested that loss of the HER2-FAK interaction, but not FAK-kinase activity, resulted in a defect in Heregulin β1-stimulated cell migration/invasion. Conclusion: We have identified a direct interaction between HER2 and FAK that is required for HER2-dependent oncogenic signaling and is amenable to targeting by small molecule therapeutics. In addition, this interaction mediated a novel drug resistance mechanism whereby HER2 rescued and maintained FAK activation under FAK-kinase inhibition. Citation Format: Timothy Marlowe, Sheila Figel, Felicia Lenzo, Vita Golubovskaya, Elena Kurenova, Alexander Tropsha, William Cance. Human epidermal growth factor receptor 2 (HER2) directly binds and activates focal adhesion kinase (FAK) to promote oncogenesis. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2015 Nov 5-9; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr A64.
Local polynomial periodograms for signals with the time-varying frequency and amplitude (2002)

The estimation of the time-varying IF /spl Omega/(t) and amplitude A(t) of harmonic signals is considered. The nonparametric local polynomial approximation (LPA) is used in order to develop two new estimators, which enable one to estimate /spl Omega/(t), /spl Omega//sup (1)/(t), ..., /spl Omega/((m/sub /spl omega//-1))(t) and A(t), A/sup (1)/(t), ..., A((m/sub A/))(t), where m/sub /spl omega// and m/sub A/ are the degrees of the LPA of the phase and the amplitude. The a priori amplitude information about /spl Omega/(t), A(t) and their derivatives can be incorporated in order to improve the estimates. The estimators of the IF and the amplitude have forms of generalized periodograms and Fourier transforms respectively, where a polynomial function appears in the degree of the complex exponent usual for the Fourier transform. The asymptotic bias and covariance are obtained for the new estimators. In particular, it is shown that one of the new estimators ensures complete compensation of the disturbing influence of the time-varying amplitude for the estimation of the IF and vice versa.
Conformation of endo-bicyclo[3.3.1]nonan-3-ol. New synthesis of oxaadamantane (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformation of endo-bicyclo[3.3.1]nonan-3-ol. New synthesis of oxaadamantaneM. Fisch, Stephen H. Smallcombe, Jean C. Gramain, M. A. McKervey, and J. E. AndersonCite this: J. Org. Chem. 1970, 35, 6, 1886–1890Publication Date (Print):June 1, 1970Publication History Published online1 May 2002Published inissue 1 June 1970https://pubs.acs.org/doi/10.1021/jo00831a036https://doi.org/10.1021/jo00831a036research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation (2003)

Although the physiological role of uncoupling proteins (UCPs) 2 and 3 is uncertain, their activation by superoxide and by lipid peroxidation products suggest that UCPs are central to the mitochondrial response to reactive oxygen species. We examined whether superoxide and lipid peroxidation products such as 4-hydroxy-2-trans-nonenal act independently to activate UCPs, or if they share a common pathway, perhaps by superoxide exposure leading to the formation of lipid peroxidation products. This possibility can be tested by blocking the putative reactive oxygen species cascade with selective antioxidants and then reactivating UCPs with distal cascade components. We synthesized a mitochondria-targeted derivative of the spin trap alpha-phenyl-N-tert-butylnitrone, which reacts rapidly with carbon-centered radicals but is unreactive with superoxide and lipid peroxidation products. [4-[4-[[(1,1-Dimethylethyl)-oxidoimino]methyl]phenoxy]butyl]triphenylphosphonium bromide (MitoPBN) prevented the activation of UCPs by superoxide but did not block activation by hydroxynonenal. This was not due to MitoPBN reacting with superoxide or the hydroxyl radical or by acting as a chain-breaking antioxidant. MitoPBN did react with carbon-centered radicals and also prevented lipid peroxidation by the carbon-centered radical generator 2,2'-azobis(2-methyl propionamidine) dihydrochloride (AAPH). Furthermore, AAPH activated UCPs, and this was blocked by MitoPBN. These data suggest that superoxide and lipid peroxidation products share a common pathway for the activation of UCPs. Superoxide releases iron from iron-sulfur center proteins, which then generates carbon-centered radicals that initiate lipid peroxidation, yielding breakdown products that activate UCPs.