gebhart/patrepeval huggingface dataset:
Truncated C-terminus of fibrillin-1 induces Marfanoid-progeroid-lipodystrophy (MPL) syndrome in rabbit (2018)

Various clinical differences have been observed between patients with the <i>FBN1</i> gene mutation and those with the classical Marfan phenotype. Although <i>FBN1</i> knockout (KO) or dominant-negative mutant mice are widely used as an animal model for Marfan syndrome (MFS), these mice cannot recapitulate the genotype/phenotype relationship of Marfanoid-progeroid-lipodystrophy (MPL) syndrome, which is caused by a mutation in the C-terminus of fibrillin-1, the penultimate exon of the <i>FBN1</i> gene. Here, we describe the generation of a rabbit MPL model with C-terminal truncation of fibrillin-1 using a CRISPR/Cas9 system. <i>FBN1</i> heterozygous (<i>FBN1</i> Het) rabbits faithfully recapitulated the phenotypes of MFS, including muscle wasting and impaired connective tissue, ocular syndrome and aortic dilation. Moreover, skin symptoms, lipodystrophy, growth retardation and dysglycemia were also seen in these <i>FBN1</i> Het rabbits, and have not been reported in other animal models. In conclusion, this novel rabbit model mimics the histopathological changes and functional defects of MPL syndrome, and could become a valuable model for studies of pathogenesis and drug screening for MPL syndrome.
Possibilities for continuous glucose monitoring by a functional contact lens (2010)

This article discusses about the development of a range of fabrication technologies that enable the construction of a sophisticated system for the detection of glucose from the tear film. It also demonstrates the operation of a sensor with enough sensitivity to function on the surface of the eye. Currently, work is being done on integrating these sensors with the related control circuitry on contact lenses. These functional contact lenses hold much promise in biomedical research and patient care in the near future.
Continuous flow measurement of beta radiation using suspended scintillators (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTContinuous flow measurement of beta radiation using suspended scintillatorsEugene T. McGuinness and Martin C. Cullen Cite this: J. Chem. Educ. 1970, 47, 1, A9Publication Date (Print):January 1, 1970Publication History Received3 August 2009Published online1 January 1970Published inissue 1 January 1970https://doi.org/10.1021/ed047pA9RIGHTS & PERMISSIONSArticle Views63Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (8 MB) Get e-Alerts Get e-Alerts
Covalent adaptable networks: smart, reconfigurable and responsive network systems (2013)

Covalently crosslinked materials, classically referred to as thermosets, represent a broad class of elastic materials that readily retain their shape and molecular architecture through covalent bonds that are ubiquitous throughout the network structure. These materials, in particular in their swollen gel state, have been widely used as stimuli responsive materials with their ability to change volume in response to changes in temperature, pH, or other solvent conditions and have also been used in shape memory applications. However, the existence of a permanent, unalterable shape and structure dictated by the covalently crosslinked structure has dramatically limited their abilities in this and many other areas. These materials are not generally reconfigurable, recyclable, reprocessable, and have limited ability to alter permanently their stress state, topography, topology, or structure. Recently, a new paradigm has been explored in crosslinked polymers - that of covalent adaptable networks (CANs) in which covalently crosslinked networks are formed such that triggerable, reversible chemical structures persist throughout the network. These reversible covalent bonds can be triggered through molecular triggers, light or other incident radiation, or temperature changes. Upon application of this stimulus, rather than causing a temporary shape change, the CAN structure responds by permanently adjusting its structure through either reversible addition/condensation or through reversible bond exchange mechanisms, either of which allow the material to essentially reequilibrate to its new state and condition. Here, we provide a tutorial review on these materials and their responsiveness to applied stimuli. In particular, we review the broad classification of these materials, the nature of the chemical bonds that enable the adaptable structure, how the properties of these materials depend on the reversible structure, and how the application of a stimulus causes these materials to alter their shape, topography, and properties.
Dexamethasone Down-Regulates Expression of Triggering Receptor Expressed on Myeloid Cells-1: Evidence for a TNFα-Related Effect (2013)

TREM-1/sTREM-1 is a novel site of action of dexamethasone. This action is associated with down-regulation of gene expression and is mediated by TNFα.
Decentralized control of hybrid systems (2002)

The key issue of a multi agent system is the decentralized control and optimization of a given global system which is normally of large scale. In this connection features like stability, controllability, and observability are important aspects. The paper deals with control structures of decentralized agent driven hybrid systems. In addition some stability features of decentralized hybrid systems are discussed. An example of agent control of two coupled heaters shows that even stable systems may show periodic behavior.
Coordinated Self-Configuration of Virtual Machines and Appliances Using a Model-Free Learning Approach (2012)

Cloud computing has a key requirement for resource configuration in a real-time manner. In such virtualized environments, both virtual machines (VMs) and hosted applications need to be configured on-the-fly to adapt to system dynamics. The interplay between the layers of VMs and applications further complicates the problem of cloud configuration. Independent tuning of each aspect may not lead to optimal system wide performance. In this paper, we propose a framework, namely CoTuner, for coordinated configuration of VMs and resident applications. At the heart of the framework is a model-free hybrid reinforcement learning (RL) approach, which combines the advantages of Simplex method and RL method and is further enhanced by the use of system knowledge guided exploration policies. Experimental results on Xen-based virtualized environments with TPC-W and TPC-C benchmarks demonstrate that CoTuner is able to drive a virtual server cluster into an optimal or near-optimal configuration state on the fly, in response to the change of workload. It improves the systems throughput by more than 30 percent over independent tuning strategies. In comparison with the coordinated tuning strategies based on basic RL or Simplex algorithm, the hybrid RL algorithm gains 25 to 40 percent throughput improvement.
Vertical MOS Transistors with 70nm Channel Length (1995)

Vertical nMOS transistors with channel lengths down to 70nm and thin gate oxides have been fabricated using LPCVD epitaxy for the definition of the channel region instead of fine line lithography. The devices show drain current and transconductance values comparable to very advanced planar transistors. For the shortest channel length a stronger increase of current is observed and is attributed to ballistic and floating substrate effects. Besides high saturation currents due to very short channel lengths a higher integration density seems to be feasible using this vertical transistor technology.
Channel modeling and adaptive equalization of indoor radio channels (1989)

The authors analyze the benefits of using a decision feedback equalizer (DFE) in the indoor radio environment and examine the results of performance predictions for different channel modelings. It is found that a QPSK/DFE modem with second-order diversity can operate at a data rate that is an order of magnitude higher than a QPSK (quadratic-phase-shift-keying) modem without equalization. A given set of measured profiles of the channel impulse response is interpreted using continuous and discrete channel models. The continuous channel model is represented by the delay power spectrum and the discrete channel model by the envelope delay power spectrum and the arrival rate of the paths. The sensitivity of the performance to the shape of the delay power spectrum, and the arrival rate of the paths is analyzed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Interactions with Hydrophobic Clusters in the Urea‐Unfolded Membrane Protein OmpX (2007)

A denatured membrane protein in 8 M urea was characterized. Two hydrophobic clusters, separated by 50 amino acids in the polypeptide chain, are shown to bind independently to detergent micelles (see picture). Long-range interactions between the two clusters are not observed. These observations provide new insights into protein folding mechanisms. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z703367_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The anti-tumor activities of Neferine on cell invasion and oxaliplatin sensitivity regulated by EMT via Snail signaling in hepatocellular carcinoma (2017)

Tumor invasion and chemotherapy resistance, which are associated with epithelial-mesenchymal transition (EMT), remain as major challenges in hepatocellular carcinoma (HCC) treatment. Neferine, a natural component of Nelumbo nucifera, have been proven the antitumor efficiency in cancer, but the effects of Neferine on HCC invasion and chemosensitivity need to be elucidated. Applying multiple assays of cell proliferation, flow cytometry, immunofluorescence staining, qRT-PCR, Western blot, fluorescence molecular tomography imaging, the influences of Neferine on EMT-regulated viability, apoptosis, invasion, and oxaliplatin (OXA) sensitivity were assessed in HCC cells of HepG2 and Bel-7402, as well as in xenograft animal models in vivo. Here, we reported that Neferine had no obvious effects on HCC cells proliferation, but significantly enhanced cytotoxicity and apoptosis caused by OXA in vitro and in vivo. Through an upregulation of E-cadherin and downregulation of Vimentin, Snail and N-cadherin, Neferine suppressed EMT-induced migration and invasion abilities of HCC cells. TGF-β1 cancelled the effects of Neferine on the migration and invasion of HCC cells. Snail overexpression or TGF-β1-induced EMT attenuated Neferine-mediated OXA sensitization in HCC. Together, our data suggest that Neferine enhances oxaliplatin sensitivity through an inhibition of EMT in HCC cells. Neferine may be used as an OXA sensitizer in HCC chemotherapy.
Stability of Bacillus thuringiensis and Baculovirus heliothis on Soybean Foliage2 (1974)

The half-life of spores and endocrystals of Bacillus thuringiensis Berliner on soybean leaves was less than 24 h, since 65% of the insecticidal activity, and 90% of the spore viability, was lost during the 1st day. However, some insecticidal activity could be detected at 7 days postapplication. The half-life of the nucleopolyhedrosis virus of Heliothis (Baculovirus heliothis) was >2 <3 days. Viral activity could not be detected after 14 days' exposure on soybean leaves.
Safety and Efficacy of Low Anterior Resection for Rectal Cancer (1999)

The use of preoperative chemoradiation results in increased operative time, blood loss, and pelvic abscess formation but does not increase the rate of anastomotic leaks or the length of hospital stay after low anterior resection for rectal cancer. The 5-year actuarial overall survival rate for patients undergoing curative resection exceeded 80%, with a local recurrence rate of 10%.
The genetic link between the Chinese bamboo partridge (Bambusicola thoracica) and the chicken and junglefowls of the genus Gallus. (1995)

Further comparison of mitochondrial control-region DNA base sequences of 16 avian species belonging to the subfamily Phasianinae revealed the following: (i) Generalized perdicine birds (quails and partridges) are of ancient lineages. Even the closest pair, the common quail (Coturnix coturnix japonica) and the Chinese bamboo partridge (Bambusicola thoracica), maintained only 85.71% identity. (ii) The 12 species of phasianine birds previously and presently studied belonged to three distinct branches. The first branch was made exclusively of members of the genus Gallus, while the second branch was made of pheasants of the genera Phasianus, Chrysolophus, and Syrmaticus. Gallopheasants of the genus Lophura were distant cousins to these pheasants. The great argus (Argusianus argus) and peafowls of the genus Pavo constituted the third branch. The position of peacock-pheasants of the genus Polyplectron in the third branch was similar to that of the genus Lophura in the second branch. Members of the fourth phasianine branch, such as tragopans and monals, were not included in the present study. (iii) The one perdicine species, Bambusicola thoracica, was more closely related to phasianine genera Gallus and Pavo than to members of other perdicine genera. The above might indicate that Bambusicola belong to one-stem perdicine lineage that later splits into two sublineages that yielded phasianine birds, one evolving to Gallus, and the other differentiating toward Pavo and its allies.
ChemInform Abstract: Synthesis and Properties of Cyclopropanated 2,2′‐Binaphthoquinones. (1990)

Abstract Some title compounds are prepared by addition of diazomethane to the binaphthoquinone (I).
Proportional decline of Anopheles quadriannulatus and increased contribution of An. arabiensis to the An. gambiae complex following introduction of indoor residual spraying with pirimiphos-methyl: an observational, retrospective secondary analysis of pre-existing data from south-east Zambia (2018)

It seems likely that An. arabiensis is not only more behaviourally resilient against IRS than An. gambiae, but also than An. quadriannulatus populations exhibiting indoor-feeding, human-feeding and nocturnal behaviours that are unusual for this species. Routine, programmatic entomological monitoring of dynamic vector population guilds will be critical to guide effective selection and deployment of vector control interventions, including supplementary measures to tackle persisting vectors of residual malaria transmission like An. arabiensis.
Mesoplodon densirostris transmission beam pattern estimated from passive acoustic bottom mounted hydrophones and a DTag recording (2008)

The transmission beam pattern of a female Mesoplodon densirostris tagged on October 23, 2006 in the Tongue of the Ocean, Bahamas is estimated using data from a Woods Hole Oceanographic Institution DTag and simultaneous recordings from broadband, bottom mounted hydrophones at the Atlantic Undersea Test and Evaluation Center, Andros Island, Bahamas. The bottom mounted hydrophones are used to localize the tagged animal and measure the received level of each click. Pitch, roll and heading from the DTag are used to determine the horizontal and vertical aspect angles relative to the hydrophone. An estimate of the M. densirostris horizontal and vertical transmission beam pattern based on four dives will be presented.
ChemInform Abstract: THE REGION OF STABILITY OF GREEN RUST II IN THE ELECTROCHEMICAL POTENTIAL‐PH EQUILIBRIUM DIAGRAM OF IRON IN SULPHATE MEDIUM (1975)

Abstract Bei der Oxidation von Fe(OH) 2 in sulfathaltigen Lösungen wird der Vorgang Abeobachtet.
Fixing the Java bytecode verifier by a suitable type domain (2002)

The Java Virtual Machine embodies a verifier which performs a set of checks on bytecode programs before their execution. The verifier performs a data-flow analysis applied to a type-level abstract interpretation of the code. The current implementations of the bytecode verifier present a significant problem: there are legal Java programs which are correctly compiled into a bytecode that is rejected by the verifier. Also the more powerful verification techniques proposed in several papers suffer from the same problem. In this paper we propose to enhance the bytecode verifier to accept such programs, maintaining the efficiency of current implementations. The enhanced version is based on a domain of types which is more expressive than the one used in standard verification.
Perceptual Quality Metric for H.264 Low Bit Rate Videos (2006)

This paper proposed an objective video quality metric designed for automatically assessing the perceived quality of digitally compressed multimedia videos using H.264 video compression. The rationale in proposing perceptual-based metric is because traditional measure, peak signal-to-noise ratio (PSNR), has been found to correlate poorly with subjective quality ratings, particularly at much lower bit rates. In this paper, computational models have been applied to emulate human visual perception based on a combination of local and global modulating factors. The proposed video quality metric has been tested on GIF and QCIF video sequences compressed using H.264 video compression technique at various bit rates (24-384 Kbps) and frame rates (7.5-30 Hz). Performance of the proposed metric with respect to subjective scores will be reported and a comparison with PSNR and also the video structural similarity method (being one of the best video quality metric for high bit rate videos recently reported in the literature) will also be provided in this paper
An Objective Analysis Method for Perceptual Quality of a Virtual Bass System (2015)

Due to the physical size and frequency response constraints of miniaturized and flat panel loudspeakers, low frequency reproduction from these loudspeakers is generally limited and unsatisfactory. The virtual bass system (VBS) enhances the bass performance of such loudspeakers by tricking the human brain to perceive the fundamental frequency from its higher harmonics. Problematically, the additional harmonics from VBS can also introduce perceptual distortion and reduce the audio quality. Therefore, a reliable method to assess the quality of VBS-enhanced signals is necessary in the designing of VBS. Since subjective experiments are often time-consuming and may be inconsistent, it is desirable to develop an objective assessment method for VBS. Earlier studies only utilized some simple objective metrics, which generally do not consider the human auditory model and are unable to accurately predict the perceptual quality of VBS. In this paper, we introduce a perceptual quality-assessment method for VBS based on the model output variables (MOVs) of the ITU Recommendation ITU-R BS.1387. Suitable combinations of MOVs are selected to derive perceptual quality metrics that correlate closely to the subjective quality. A verification experiment is presented to justify the accuracy of the metrics.
CD11/CD18-independent neutrophil adherence to inducible endothelial-leucocyte adhesion molecules (E-LAM) in vitro. (1989)

We examined the mechanisms involved in neutrophil adherence to cultured human umbilical vein endothelial cells (HEC) induced by direct stimulation of the neutrophils by phorbol myristate acetate (PMA), formylmethionyl-leucyl-phenylalanine (FMLP), or the calcium ionophore A23187 (neutrophil-dependent adherence), or by pretreatment of HEC with interleukin-1 (IL-1), tumour necrosis factor (TNF) or lipopolysaccharide (LPS) (endothelial-dependent adherence). Two distinct mechanisms for neutrophil adherence to HEC were demonstrated by performing adherence assays: (i) at 37 degrees versus 4 degrees; (ii) in the presence of Ca2+ only versus Mg2+ only; and (iii) in the presence or absence of monoclonal antibodies (mAb) to the CD11/CD18 adhesion complex of neutrophils. A CD11/CD18-dependent mechanism (i.e. inhibited by anti-CD18 mAb) was identified that was active in the presence of Mg2+ only but not of Ca2+ only, and at 37 degrees but not at 4 degrees. A CD11/CD18-independent mechanism (i.e. not inhibited by anti-CD18 mAb) was active at 4 degrees and at 37 degrees, and in the presence of Ca2+ only and of Mg2+ only. Neutrophil-dependent adherence induced by FMLP or PMA occurred solely via the CD11/CD18-dependent mechanism, whereas endothelial-dependent adherence induced by a 4-hr pretreatment with IL-1, TNF, or LPS involved both CD11/CD18-dependent and/independent mechanisms. CD11/CD18-deficient neutrophils isolated from a patient with leucocyte adherence deficiency (LAD) maintained the ability to adhere to LPS-pretreated HEC in the presence of Ca2+ only, indicating that this mechanism of adherence involves a receptor on the neutrophil distinct from CD11/CD18. Furthermore, the disappearance of the CD11/CD18-independent, but not of the CD11/CD18-dependent mechanism of adherence, in HEC treated with TNF for 24 hr suggests that the two mechanisms of neutrophil adherence also involve distinct inducible endothelial-leucocyte adhesion molecules (E-LAM).
The Role of Na+/H+ Exchange and Growth Factors in Pulmonary Artery Smooth Muscle Cell Proliferation (1996)

Chronic hypoxia produces pulmonary hypertension, in part because of hypertrophy and hyperplasia of pulmonary artery smooth muscle cells (PA SMC). Platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) have been shown to stimulate SMC proliferation and may be involved in these vascular changes. Both factors cause a rise in intracellular pH (pHi) in systemic vascular SMC through stimulation of the Na+/H+ exchanger, an event that has been thought to be permissive, allowing cell proliferation in response to the growth factor. The present studies examined the possibility that the activation of Na+/H+ exchange is involved in the PA SMC mitogenic response to these growth factors. Na+/H+ exchange activity was assessed by monitoring pHi in cultured cells using the pH-sensitive dye, 2'7'-bis(carboxyethyl)-5(6)-carboxyfluorescein (BCECF). PDGF (60 ng/ml) exposure led to a marked activation of Na+/H+ exchange, evidenced by a rise in pHi (mean +/- SEM) of 0.20 +/- 0.03 pH units (n = 5, P < 0.05). EGF (60 ng/ml) exposure produced a rise in pHi of 0.27 +/- 0.03 pH units (n = 5, P < 0.05). Dimethyl amiloride (DMA, 50 microM), a competitive inhibitor of Na+/H+ exchange, blocked the pH response to PDGF and EGF. PA SMC showed a proliferative response when exposed to PDGF and EGF which was attenuated by 50 microM DMA (n = 6). Thus, activation of the Na+/H+ exchanger may be important in pulmonary cell signaling in response to growth factors as it has been found to be in systemic vessels.