gebhart/patrepeval huggingface dataset:
Design of Low-Level Hardware for a Multi-Layered Control Architecture (2022)

Abstract In this work, the low-level (LL) hardware for sensor collection, motor input, and networking with a high-level (HL) controller is presented for robot systems which utilize linear series elastic actuators (LSEAs) for joint actuation. In multi-joint robotic systems, LL controllers rely on sensor readings to control each joint and communicate the obtained information to the HL controller. This research outlines the hardware design of two printed circuit boards (PCBs), as well as the use of an EasyCAT PRO board for communication. An in-house sensor interface shield is designed as an extension of the TM4C123GXL TIVA microcontroller launchpad and another in-house shield connects to the AZBDC12A8 analog servo drive, or rather, the motor controller. These PCBs allow for sensor integration with circuits that route, filter, or manipulate data obtained from the sensors. The goal of the sensor interface shield is to interface between sensors and the microcontroller. The sensor board takes readings from a force sensor, absolute encoder, quadrature encoder, as well as adjusting the pulse-width modulation (PWM) signal that is sent to the motors. The main purpose of the motor shield is to supply power, route the PWM input, and filter the current output of the motor. The final designs for both the shields are built in the PCB design software Eagle. Overall, these boards will allow for better sensor integration for LL controllers which interface with LSEA driven multi-joint robotic systems.
Optimized Multiplex Polymerase Chain Reaction: An Effective Method for Rapid Gap Closure (2004)

Implementation of the whole-genome shotgun sequencing approach to prokaryotes and eukaryotes necessitates methods for rapid gap closure. During a whole-genome shotgun sequencing project, DNA sequences are aligned against each other to create continuous assemblies or contigs (1). However, some areas of the genome are not represented owing to repeats, secondary structure, or toxicity in Escherichia coli. When no cloned template is available for sequencing, these gaps must be resolved by polymerase chain reaction (PCR), testing primers from each contig end against primers from all the other contig ends in all the possible combinations. When dealing with large genomes, generating templates for numerous gaps by only combinatorial PCR is cumbersome and inefficient. Optimized Multiplex PCR (2) provides an effective new method for the rapid closure of a large number of gaps. Its framework for minimizing the number of PCR pipetting steps is achieved by combining Multiplex PCR (3) with a mathematical method (4). Unlike combinatorial PCR, Optimized Multiplex PCR minimizes the number of reactions by combining primers into pools and testing these pools against each other. This method has been successfully implemented in the closure of numerous genomes at The Institute for Genomic Research. In this chapter, we provide a simple guide to the Optimized Multiplex PCR method by describing in detail the steps involved in primer design, primer pooling, Multiplex PCR, and multiplex sequencing.
Biochemical composition and nutritional value of Balanites aegyptiaca (L.) Del fruit pulps from Northern Ferlo in Senegal (2014)

Balanites aegyptiaca, a forest species of socio-economic interest for rural people, was chosen to be planted in the frame-work of the Great Green Wall project in Senegal. Although in vastly demand during food scarcity period before crops harvest, the species&rsquo; fruit is poorly valued despite its important production. In this study, the fruit pulps were harvested at maturity and the biochemical characteristics were accessed in order to better understand the fruit&rsquo;s nutritional value. The moisture, sugars, proteins, amino acids, ash, fat, minerals and some vitamins were determined by standard methods of analysis. The results indicated that the fruits are a good alimentary source of sugar, minerals (mainly potassium) and ascorbic acid. The pulp proteins were qualitatively balanced, but were present only in weak quantities. Its caloric value is high due to the high concentration of sugars. Low humidity should allow a fairly good postharvest fruit conservation. The dietary intake of this fruit for local people is very valuable especially in terms of nutrition. &nbsp; Key words: Balanites aegyptiaca, pulp, biochemical, nutritional value.
Linear multipass processes: a two-dimensional interpretation (1980)

A large class of discrete multipass processes can be viewed as two-dimensional systems of the form proposed by Roesser. It is shown that the criterion for stability along the pass is equivalent to Shanks condition for two-dimensional b.i.b.o. stability. The interplay of ideas between the two disciplines should make possible the emergence of a coherent feedback control and systems theory for multipass processes.
Sizing considerations for ultracapacitors in hybrid energy storage systems (2011)

Ultracapacitors are energy storage devices that can be connected in parallel with batteries to create a hybrid power system. The hybrid configuration provides a higher power density compared to a single battery and leads to an extended life of the batteries. One other issue is the voltage regulation of a battery supplied dc bus subjected to a pulsed load. In the aerospace field the bus voltage must be maintained within certain margins. Batteries subjected to pulsed loads generate terminal voltages with voltage dips that can exceed the voltage regulation band. The purpose of this study is to see to what extent an ultracapacitor placed in parallel with a battery can assist in maintaining a bus voltage within the regulatory limits.
A Numerical Method to Solve Nonsymmetric Eigensystems Applied to Dynamics of Turbomachinery (2019)

In this paper, a canonical transformation is proposed to solve the eigenvalue problem related to the dynamics of rotor-bearing systems. In this problem, all matrices are real, but they may not be symmetric, which leads to the appearance of complex eigenvalues and eigenvectors. The bi-iteration method is selected to solve the original eigenproblem whereas the QR algorithm is adopted to solve the reduced or projected problem. A new canonical transformation of the global eigenproblem which reduces the quadratic eigenproblem to a linear eigenproblem, maintaining numerical stability since all that is required is that the stiffness matrix is well-conditioned, which is always true when it comes to applications in dynamic problems. The proposed technique is good for obtaining dominant eigenvalues and corresponding eigenvectors of real nonsymmetric matrices and it possesses the following properties: (i) the matrix is not transformed, therefore sparsity is maintained, (ii) partial eigensolutions can be obtained and (iii) use may be made of good eigenvectors predictions.
Photocontrolled Reversible Supramolecular Assemblies of an Azobenzene‐Containing Surfactant with α‐Cyclodextrin (2007)

Inclusion and exclusion of an azobenzene-containing surfactant with α-cyclodextrin (α-CD) can be used to fabricate photostimulus-responsive vesicle-like aggregates that can undergo assembly and disassembly reversibly (see picture). The movement of α-CD is like that of a molecular shuttle.
cataract surgical problem (1999)

Journal of Cataract & Refractive Surgery: November 1999 - Volume 25 - Issue 11 - p 1427-1428 doi: 10.1016/S0886-3350(99)00278-3
Ambulatory 24-hour electrocardiographic monitoring following total cavopulmonary connection. (1999)

A total of 72 patients (53 males, 19 females) in the age range 1-22 years (mean 6.4 years) who underwent univentricular repair between April 1990 and May 1997 at our institute were followed up from six months to seven years (mean 3.6 years). Twenty-four hours ambulatory electrocardiographic Holter monitoring was done in all the patients. Thirty-four out of 40 patients (85%) who underwent fenestrated total cavopulmonary connection and 25 out of 32 patients (78%) who underwent non-fenestrated total cavopulmonary connection had normal Holter recording; thus 59 out of 72 (82%) patients had normal findings. Among the fenestrated total cavopulmonary connections, three patients each had atrial tachycardia and sinus bradycardia. In the non-fenestrated group, two patients had atrial tachycardia, three had supraventricular tachycardia, one sinus bradycardia and one had intermittent ventricular tachycardia. No correlation was found between age at surgery, pre-operative morphology, cross clamp time or cardiopulmonary bypass time with post-operative arrhythmia. To conclude, post-operative arrhythmias following total cavopulmonary connection were not related to age at surgery, pre-operative morphology, cross clamp or cardiopulmonary bypass time. However, a larger patient pool and longer follow-up is required for evaluation of any definitive correlation.
Smaller Hippocampal Volume Is Associated With Reduced Posttraumatic Stress Symptoms in Children With Cancer and Survivors Following a Brief Novel Martial Arts-Based Intervention (2023)

Together, hippocampal volume may be a biomarker of PTSS severity and intervention response. Identifying hippocampal volume as a potential biomarker for PTSS severity and intervention response may allow for more informed psychosocial treatments.
Effects of short-term supplementation with bovine lactoferrin and/or immunoglobulins on body mass and metabolic measures: a randomised controlled trial (2016)

Given the role of the intestinal microbiota in obesity and related disease, strategies to modulate the composition of the intestinal microbiota may augment traditional weight-management approaches. Here, we examined the safety and tolerability of 28 days of supplementation with bovine whey-derived lactoferrin and immunoglobulin supplements in a cross-sectional cohort of free-living adults. Participants (n = 20 each group) received enteric-coated whey-derived bovine lactoferrin (200 mg), immunoglobulin (200 mg or 800 mg), combination lactoferrin/immunoglobuiln supplements (200 mg/200 mg, 200 mg/800 mg) or placebo in a double-blind design. Supplement use was generally well tolerated and routine haematology, and clinical chemistry measures were largely unchanged following supplementation. Measures of body composition remained stable and indices of glycaemic control and blood lipids revealed fluctuations of <5% but were not significantly different between groups. Overall, short-term lactoferrin/immunoglobulin supplementation was well tolerated in this cohort; use of these types of supplements to enhance other weight management strategies should be investigated over extended periods.
Clinician Use of a Palmtop Drug Reference Guide (2002)

Self-reported perceptions by responding clinicians endorse improved access to drug information and improved practice efficiency associated with the use of handheld devices. The clinical and practical value of using these devices in clinical settings will clearly grow further as wireless communication becomes more ubiquitous and as more applications become available.
Production of Caseinophosphopeptides from Na-Caseinates Prepared from the Milk of Several Species by a Proteinase of Lactobacillus helveticus PR4 (2003)

Abstract The aim of this work was to produce caseinophosphopeptides (CPPs) from Na-caseinates prepared from the milk of six species (bovine, sheep, goat, pig, buffalo, human) hydrolyzed by a partially purified proteinase from Lactobacillus helveticus PR4 and to characterize the CPP preparations by RP-FPLC (reversed-phase fast-protein liquid chromatography) and for calcium solubilizing/binding activity. The yield of CPPs ranged from 0.60 to 1.86% of the original proteins. The calcium-solubilizing activity varied from 2.5 (human CPPs) to 11.4 (buffalo CPPs) mg Ca2+ mg−1 CPP. Moreover, minor differences in calcium-binding ability between the CPP from different species were observed. This work showed that CPPs with different calcium-solubilizing activity can be produced from various Na-caseinates by a Lb. helveticus proteinase. Milks having casein-fractions with similar amino acid sequences (e.g., sheep and goat), showed CPPs with the same activity. The data generated in this study show the potential of different caseins to yield CPPs and may help in the selection of milk for the production of functional foods enriched in CPPs.
580 The Safety and Efficacy of Proton-Pump Inhibitors (PPI) Usage in Critical Care Patients for Stress Ulcer Prophylaxis: A Meta-Analysis of Randomized Controlled Trials (2019)

INTRODUCTION: There is some debate in current literature about the safety and efficacy of proton pump inhibitor usage in critical care patients. In this systematic review and meta-analysis we assessed the the Safety and efficacy of proton-pump inhibitors (PPI) usage in critical care patients for stress ulcer prophylaxis METHODS: We searched PubMed, Embase, Web of Science and Cochrane Central Register of Controlled Trials following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement from inception until January 2019. We included randomized controlled trials (RCTs) that examined the efficacy and safety of proton pump inhibitors (PPIs) vs placebo regardless of publication source, status and language with participants older than 18 year old and of any gender who were admitted to medical, surgical or neuro intensive care unit (ICU). We excluded studies in which participants were admitted to ICUs primarily for the management of GI bleeding. Seven eligible studies were included and relevant data was extracted and statistical analysis was performed using Rev Man 5.3. RESULTS: Of 57 potentially eligible studies, we included 7 trials enrolling 4021 patients. The results showed that PPIs are probably more effective for preventing non clinically significant gastrointestinal bleed (GI bleed) [Odds ratio (OR) 0.47; 95% Confidence interval (95% CI) 0.37, 0.6] and clinically significant GI bleed -reported in 4 studies- (OR 0.59, 95% CI 0.40, 0.86). PPIs did not increase the risk of developing infection [including pneumonia and Clostridium difficile infection (c-diff) ] compared with placebo (OR 1.02, 95% CI 0.86, 1.22) even with sub analysis: pneumonia (OR 1.03, 95% CI 0.86, 1.23) and c-diff (OR .80, 95% CI 0.45, 1.44) . Estimates of baseline risks of bleeding varied significantly across studies, only 4 studies reported clinically significant GI bleed, 5 studies reported pneumonia (Definitions of pneumonia varied) and two studies reported on Clostridium difficile infection. CONCLUSION: PPI decreases the clinically significant and non-significant GI bleeding in critical care patients. PPI did not increase the risk of developing infection [including pneumonia and Clostridium difficile infection (c-diff) ] compared with placebo (OR 1.02, 95% CI 0.86, 1.22) even with sub analysis: pneumonia (OR 1.03, 95% CI 0.86, 1.23) and c-diff (OR .80, 95% CI 0.45, 1.44).
Study of Pd mixing during Pd-Cu wire ball formation and impact on wire bond quality (2012)

The skyrocketing price of gold has driven the rapid adoption of copper wire in semiconductor packaging. Cu wire is being used for increasingly advanced applications requiring copper wire bond to finer bond pad geometries and structures. Palladium coated Cu wire (Pd-Cu wire) has emerged as the preferred material to realize the cost benefits of Cu wire while achieving the same yield and reliability levels as Au wire. However, during the ball bond formation, the Pd-Cu wire is melted causing mixing of the Pd and Cu. This paper presents the results of a fundamental study of Pd-Cu wire mixing during the ball formation process. An Electronic Flame Off (EFO) process is used to form the ball. Pd mixing in the ball due to the EFO condition is studied. Visual appearance and quality of the ball will also be evaluated. Several bonding wires suppliers are analyzed. Resultant hardness of formed ball is measured. The impact on the stability of the bonding process to the aluminum bond pad is studied, including analysis of the bond interface and Al splash during bonding. Through this study fundamental insight into the variability of Pd mixing and appearance in formed ball related to wire supplier and EFO parameter is gained.
Long-term follow-up of glycemic and neurological outcomes in an international series of patients with sulfonylurea-treated ABCC8 permanent neonatal diabetes (2020)

&lt;b&gt;Objective &lt;/b&gt;&lt;br&gt;&lt;p&gt; &lt;i&gt;ABCC8&lt;/i&gt; mutations cause neonatal diabetes that can be transient (TNDM) or less commonly permanent (PNDM); ~90% individuals can be treated with oral sulfonylureas instead of insulin. Previous studies suggested that people with &lt;i&gt;ABCC8-&lt;/i&gt;PNDM require lower sulfonylurea doses and have milder neurological features than those with &lt;i&gt;KCNJ11-&lt;/i&gt;PNDM. However, these studies were short-term and included combinations of permanent and transient forms of &lt;i&gt;ABCC8&lt;/i&gt;-NDM. We aimed to assess the long-term glycemic and neurological outcomes in sulfonylurea-treated &lt;i&gt;ABCC8&lt;/i&gt;-PNDM. &lt;b&gt;&lt;br&gt; Research Design and Methods &lt;/b&gt;&lt;br&gt; We studied all 24 individuals with &lt;i&gt;ABCC8-&lt;/i&gt;PNDM diagnosed in the UK, Italy, France or USA known to transfer from insulin to sulfonylureas before May 2010. Data on glycemic control, sulfonylurea dose, adverse effects including hypoglycemia, and neurological features were analysed using non-parametric statistical methods. &lt;b&gt;&lt;br&gt; Results &lt;/b&gt;&lt;br&gt; Long-term data were obtained for 21/24 individuals (median follow-up 10.0 (4.1-13.2) years). 18/21 remained on sulfonylureas without insulin at most recent follow-up. Glycemic control improved on sulfonylureas (pre-sulfonylurea vs 1-year post-transfer HbA1c 7.2% vs 5.7%, p=0.0004) and remained excellent long-term (1-year vs. 10-year HbA1c 5.7% vs. 6.5%, p=0.04), n=16. Relatively high doses were used (1-year vs 10-year dose 0.37 vs 0.25mg/kg/day glyburide, p=0.50), without any severe hypoglycemia. Neurological features were reported in 13/21 individuals: these improved following sulfonylurea transfer in 7/13. The commonest features were learning difficulties (52%), developmental delay (48%), and ADHD (38%).&lt;b&gt;&lt;br&gt; Conclusions &lt;/b&gt;&lt;br&gt; Sulfonylurea treatment of &lt;i&gt;ABCC8&lt;/i&gt;-PNDM results in excellent long-term glycemic control. Overt neurological features frequently occur and may improve with sulfonylureas, supporting early, rapid genetic testing to guide appropriate treatment and neurodevelopmental assessment. &lt;/p&gt;
Effect of treatment on the expression of estramustine‐binding protein (EMBP) in prostatic cancer patients: An immunohistochemical study (1989)

Estramustine-binding protein (EMBP) was determined immunohistochemically in prostatic cancer (PC) specimens taken from patients before and after therapy. The EMBP staining intensity was correlated with the tumor malignancy grade in untreated PCs. The effect of various treatments (i.e., androgen-withdrawal therapy, treatment with estramustine phosphate or radiation) on the expression of EMBP was also investigated. Although a rabbit polyclonal antiserum raised against rat EMBP was used all through the study, all untreated PCs (n = 53) examined so far displayed a positive immunoreaction. The staining intensity was higher in moderately and poorly differentiated than in well-differentiated tumors. Furthermore, two types of staining patterns were observed, that is, a diffuse type in about 70% and a focal in the remaining cases, which might reflect the multifocal appearance of PCs. The prognostic significance of these staining patterns is discussed. Irrespective of the treatment used, EMBP staining was reduced to lower or undetectable levels in PCs where cytological as well as clinical regression were indicated after 6-30 months of therapy. In nonresponders or patients with refractory disease, however, EMBP expression reappeared and returned to pretreatment levels. In a short-term follow-up, the diminuation of EMBP was evident as early as 10 days after androgen-withdrawal therapy and persisted as long as the patient responded to therapy. When estramustine phosphate was given as secondary treatment to hormone refractory PCs, EMBP decreased to undetectable levels in 3/4 of the specimens, suggesting response to therapy. In conclusion, a decreased EMBP staining was well correlated with favorable cytological regression as well as with clinical regression, whereas unchanged staining intensity was indicative of clinical progression and a poor cytological regression grade. The high levels of EMBP in moderately and poorly differentiated tumors as well as in relapsing PCs, despite continued androgen withdrawal, strongly support a regulation of EMBP that is not under androgenic control. Based on the present findings, we suggest the use of EMBP as a therapy marker. Provided that immunohistochemical measurements can be performed on fine-needle aspirates, EMBP analysis may be a direct and early means to distinguish between responding patients and nonresponders.
Bubble Behavior of a Large‐Scale Bubble Column with Elevated Pressure (2004)

Abstract Gas holdups and the rising velocity of large and small bubbles are measured using the dynamic gas disengagement approach in a pressured bubble column of 0.3 m in diameter and 6.6 m in height. The effects of superficial gas velocity, liquid surface tension, liquid viscosity, and system pressure on the gas holdups and the rising velocity of small and large bubbles are investigated. The holdup of large bubbles and the rising velocity of small bubbles increase with increasing liquid viscosity and liquid surface tension. Meanwhile, the holdup of small bubbles and the rising velocity of a swarm of large bubbles decrease. Moreover, the holdup of large bubbles and the rising velocity of a swarm of small bubbles decrease with increasing system pressure. A correlation for the holdup of small bubbles is obtained from experimental data.
Auto-scaling techniques for elastic data stream processing (2014)

Typical use cases like financial trading or monitoring of manufacturing equipment pose huge challenges regarding end to end latency as well as throughput towards existing data stream processing systems. Established solutions like Apache S4 or Storm need to scale out to a large set of hosts to meet these challenges. An ideal system can react to workload changes by on demand acquisition or release of hosts. Thereby, it can handle unexpected peak loads as well as improve the average utilization of the system. This property is called elasticity.
The deep-subsurface sulfate reducer Desulfotomaculum kuznetsovii employs two methanol-degrading pathways (2018)

Methanol is generally metabolized through a pathway initiated by a cobalamine-containing methanol methyltransferase by anaerobic methylotrophs (such as methanogens and acetogens), or through oxidation to formaldehyde using a methanol dehydrogenase by aerobes. Methanol is an important substrate in deep-subsurface environments, where thermophilic sulfate-reducing bacteria of the genus Desulfotomaculum have key roles. Here, we study the methanol metabolism of Desulfotomaculum kuznetsovii strain 17<sup>T</sup>, isolated from a 3000-m deep geothermal water reservoir. We use proteomics to analyze cells grown with methanol and sulfate in the presence and absence of cobalt and vitamin B12. The results indicate the presence of two methanol-degrading pathways in D. kuznetsovii, a cobalt-dependent methanol methyltransferase and a cobalt-independent methanol dehydrogenase, which is further confirmed by stable isotope fractionation. This is the first report of a microorganism utilizing two distinct methanol conversion pathways. We hypothesize that this gives D. kuznetsovii a competitive advantage in its natural environment.
Facing the SARS-CoV-2 (COVID-19) outbreak with IL-6R antagonists (2020)

Cite this article as: Corominas H, Castellví I, Domingo P, Casademont J. Facing the SARS-CoV-2 (COVID-19) outbreak with IL-6R antagonists. Eur J Rheumatol 2020; 7(Suppl 2): S107-9.