gebhart/patrepeval huggingface dataset:
Primary structure and differential expression of β‐amylase in normal and mutant barleys (1987)

The primary structure of barley endosperm beta-amylase, an enzyme which catalyses the liberation of maltose from 1,4-alpha-D-glucans, has been deduced from the nucleotide sequence of a cloned full-length cDNA. The mRNA is 1754 nucleotides long [excluding the poly(A) tail] and codes for a polypeptide of 535 amino acids with a relative molecular mass of 59,663. The deduced amino acid sequence was compared with the sequences of ten peptides obtained from the purified enzyme and unambiguous identification was obtained. The N-terminal region of the deduced sequence was identical to a 12-residue cyanogen-bromide-peptide sequence, indicating that beta-amylase is synthesized as the mature protein. A graphic matrix homology plot shows four glycine-rich repeats, each of 11 residues, preceding the C-terminus. Southern blotting of genomic DNA demonstrates that beta-amylase is encoded by a small gene family, while cDNA sequence analysis indicates the presence of at least two types of mRNA in the endosperm. Dot and northern blot analysis show that Hiproly barley contains greatly increased levels of beta-amylase mRNA compared to the normal cultivar Sundance, whereas Risø mutant 1508 contains only trace amounts. These results correlate well with the deposition of beta-amylase during endosperm development in these lines. Low but similar amounts of beta-amylase mRNAs sequences were detected in leaves and shoots from normal and mutant barleys, demonstrating that the mutant lys3a (1508) and lysl (Hiproly) genes do not affect the expression of beta-amylase in these tissues.
The Quest toward limb regeneration: a regenerative engineering approach (2016)

The Holy Grail to address the clinical grand challenge of human limb loss is to develop innovative strategies to regrow the amputated limb. The remarkable advances in the scientific understanding of regeneration, stem cell science, material science and engineering, physics and novel surgical approaches in the past few decades have provided a regenerative tool box to face this grand challenge and address the limitations of human wound healing. Here we discuss the convergence approach put forward by the field of Regenerative Engineering to use the regenerative tool box to design and develop novel translational strategies to limb regeneration.
Oxidation of Iron(II) in Acidic Chloride Solutions (1983)

An experimental study was made of oxidation with air at below 80C of iron(II) chloride solutions with 2 <pHG 5.During the course of oxidation the pH was kept at a constant value by varying the ammonia content in air.It has been found that the formation of r-FeO(OH) with or without a-FeO(OH) takes place by selecting the pH and oxidation temperature, and that the presence of extremely fine 7-FeO(OH) particles in the iron(II) chloride solution facilitates the formation of needlelike r-FeO(OH) particles by oxidation.
Electric and magnetic properties of the morpholinium (TCNQ)2 family (1985)

Dit proefschrift gaat over de fysische eigenschappen van een groep van chemisch nauw verwante TCNQ zouten en het verband tussen deze eigenschappen en de kristalstructuren. TCNQ zouten behoren tot de groep van quasi ééndimensionale organische verbindingen. In deze verbindingen bewegen de elektronen bij voorkeur in één richting namelijk langs de kolommen van TCNQ molekulen, vandaar de naam quasi ééndimensionaal. Dit gedrag treedt niet alleen op in TCNQ zouten, maar ook in vele andere verbindingen zoals die van TTF, peryleen en TMTSF. Deze verbindingen hebben de laatste 25 jaar erg in de belangstelling gestaan vanwege hun vaak ongebruikelijke gedrag en vanwege de in 1964 door Little gedane suggestie dat supergeleiding bij kamertemperatuur mogelijk zou zijn in sommige van deze verbindingen. Inmiddels zijn een aantal organische verbindingen gevonden die inderdaad supergeleidend worden, maar wel bij zeer lage temperatuur (-272'C). ... Zie: Samenvatting
Rotational spectra and van der Waals potentials of Ne–Ar (1995)

The high sensitivity and resolution of Fourier-transform microwave spectroscopy using a pulsed jet coaxial to a Fabry–Perot resonator have been exploited to measure pure rotational transitions of several isotopomers of the weakly polar Ne–Ar van der Waals dimer in natural abundance. Transitions of the most abundant isotopomer, 20Ne–40Ar, could be observed with an excellent signal-to-noise ratio with a single polarization pulse. The ground-state rotational constants for this species yield a zero-point separation of R0≂360.7 pm. Simple model van der Waals potentials have been fit to the microwave transitions for the various isotopomers, providing estimates of the equilibrium spacing at the well minimum of Re=348.0(2) pm. More elaborate potentials based on ab initio calculations or on molecular-beam scattering cross sections and thermodynamic and transport properties have also been tested. The induced electric dipole moment is estimated to be μ0=7.3(1.6)×10−33 C m [0.0022(5) D] by comparison of π/2 polarization pulses with a reference molecule (Ar–CO2) whose dipole moment is known from Stark effect splitting measurements. Uncertainties in parentheses are one standard deviation.
High-Performance Quantum-Dot Superluminescent Diodes (2004)

By inclining the injection stripe of a multiple layer stacked self-assembled InAs quantum dot (SAQD) laser diode structure of 6/spl deg/ with respect to the facets, high-power and broad-band superluminescent diodes (SLDs) have been fabricated. It indicates that high-performance SLD could be easily realized by using SAQD as the active region.
Pretreatment of near Infrared Spectral Data in Fast Biomass Analysis (2010)

The ability to rapidly evaluate the chemical composition of biomass feedstock for purposes of process monitoring and optimisation is useful for gauging the potential applications and value of such feedstocks. Near infrared (NIR) spectroscopy, coupled with multivariate analysis and data pretreatment, was evaluated to remove interference from physical heterogeneity that could mask chemical property responses. Pretreatment methods included standard normal variate (SNV), multiplicative scattering correction (MSC), 1 st derivative with the Savitzky-Golay algorithm (1 st derivative), 2 nd derivative with the Savitzky-Golay algorithm (2 nd derivative), extended multiplicative signal correction (EMSC) and combinations of 1 st derivative/2 nd derivative with SNV. Results indicated that, of these methods, EMSC was most effective for diffuse reflectance NIR analysis of lignocellulosic biomass. The EMSC-pretreated data not only best accessed the chemical similarity of the probed feedstocks in our hierarchical cluster analysis but also consistently led to the overall best prediction of the chemical composition of the biomass.
Vectorial secretion by constitutive and regulated secretory pathways in mammary epithelial cells. (1995)

Lactating mammary epithelial cells synthesize large quantities of milk proteins, which they secrete vectorially at the apical membrane into the alveolar lumen of the gland. Recent work suggested that mammary protein secretion is not wholly constitutive, but may also occur in part through a regulated secretory pathway. This study used mouse mammary epithelial cells cultured on Engelbreth-Holm-Swarm (EHS) matrix to compare the proportions of basally and apically-directed proteins secreted constitutively or in a regulated manner. On EHS matrix, mammary cells formed mammospheres, multicellular structures enshrouded in matrix material, within which they became polarised, formed tight intercellular junctions, and secreted milk proteins vectorially. Protein secreted basolaterally was collected in culture medium, whereas apically-secreted milk proteins accumulated in a closed lumen within the mammosphere, and were recovered by EGTA treatment of the cells in situ. Protein secretion was measured by following the release of radiolabelled protein after pulse-labelling with [35S]-methionine. Basolateral and apical secretion of [35S]-protein appeared complete within 1 h of pulse-labelling, consistent with immediate secretion through constitutive secretory pathways. However, addition of the calcium ionophore ionomycin induced a second wave of secretion in both directions. Ca(2+)-stimulated secretion occurred within 15 min of ionomycin addition, doubled the extent of basolateral and apical secretion, but did not change the populations of proteins secreted. Ionomycin treatment did not affect mammosphere morphology or mammary cell ultrastructure. The results suggest that lactating mammary epithelial cells secrete proteins apically and basolaterally by two pathways, one a Ca(2+)-independent constitutive pathway, the other a regulated pathway stimulated by elevation of intracellular Ca2+.
Producing and Manipulating Functional Liquid Metal Droplets using Magnetic and Electrical Fields (2019)

As an emerging multi-functional material, gallium based room temperature liquid metal attracts particular attentions in a variety of applications in recent years due to its extraordinary mobility and deformability. However, without reliable controllability, the liquid metal greatly reduces its potential applications in many fields. In this study, we proposed a new design of the functional liquid metal obtained by magnetic modification of pure liquid metal with copper-iron alloy nano-particles. The functional liquid metal droplet exhibits similar appearance, mobility, deformability and continuous electrowetting effect in alkaline solutions to those of the pure liquid metal droplet under external electrical field. Meanwhile, it enables to be controlled and manipulated by an external magnetic field precisely and quickly. The surface free energy generated during the wetting process exceeds energy barrier during the magnetic modification process, which allows the copper-iron alloy particles to suspend into the liquid metal and form the functional liquid metal. The mobility and deformability of the functional liquid metal droplet are verified by manipulation tasks in cross-linked channels and sloped channel when applying the integration of the electrical and magnetic fields. The remarkable features of the functional liquid metal represent extensive potentials toward the design of future intelligent soft robots.
The leaking battery: A privacy analysis of the HTML5 Battery Status API. (2015)

We highlight privacy risks associated with the HTML5 Battery Status API. We put special focus on its implementation in the Firefox browser. Our study shows that websites can discover the capacity of users’ batteries by exploiting the high precision readouts provided by Firefox on Linux. The capacity of the battery, as well as its level, expose a fingerprintable surface that can be used to track web users in short time intervals. Our analysis shows that the risk is much higher for old or used batteries with reduced capacities, as the battery capacity may potentially serve as a tracking identifier. The fingerprintable surface of the API could be drastically reduced without any loss in the API’s functionality by reducing the precision of the readings. We propose minor modifications to Battery Status API and its implementation in the Firefox browser to address the privacy issues presented in the study. Our bug report for Firefox was accepted and a fix is deployed.
RSV-Related Thrombocytopenia Associated with Transient Cytogenetic Abnormalities in a Recipient of Umbilical Cord Blood Transplantation (2016)

Respiratory syncytial virus (RSV) infections are associated with thrombocytopenia. The underlying mechanism of thrombocytopenia in this setting is unknown. Herein, we report a case of RSV-related thrombocytopenia associated with transient cytogenetic abnormalities that occurred following umbilical cord blood transplantation.
Distribution of ABO and Rhesus blood groups in gujarat, India : a hospital based study (1998)

Blood group distribution shows a wide geographical variation. It is important for running and planning blood banking services, in a setup, to know the distribution pattern in the place where these services are located and the population it caters to. We carried out a retrospective analysis of voluntary blood donations over the last six months at the Gujarat Cancer and Research Institute (GCRI) to understand the blood group distribution patterns prevailing in Gujarat. During the period from November 1995 to May 1996, a total of 5278 volunteers donated blood. Blood group B was found to be the commonest (35.5 percent) followed by O (32.5 percent), A (23.3 percent) and AV (8.8 percent), 5.8 percent of the total donors were Rhesus negative. A significant difference was observed in blood group distribution compared to earlier series from Gujarat and Southern Indian states, while difference was statistically not significant when compared with other Northern states.
Arbitrary-path fly-scan ptychography (2018)

Ptychography is a coherent diffractive imaging method that can provide a diffraction-limited, robust reconstruction of the sample's complex transmission function without the use of high-quality optics. However, the scanning nature of conventional X-ray ptychography unavoidably requires the mechanical motion of either the illumination probe or the sample. In order to avoid overhead related to breaking and acceleration for every scan position, so-called fly-scan methods were developed. Here, we present an improved variant that removes the limitation of continuous scanning along a linear scanning path and allows for ptychographic reconstruction of scans taken along an arbitrary 2D continuous trajectory. We also demonstrate numerically and experimentally that our method provides significantly improved robustness against noise, particularly for larger fly-scan steps, i.e. sample shift during an exposure, which will gain importance with the advent of 4th generation synchrotron sources, where the available coherent flux may be increased by orders of magnitude. Finally, we show that the use of a spiral scan continuous trajectory alleviates significantly raster grid artifacts.
An effective programmable prefetch engine for on-chip caches (1995)

Prefetching has been shown to be one of several effective approaches that can tolerate large memory latencies. In this paper, we consider a prefetch engine called Hare, which handles prefetches at run time and is built in addition to the data pipelining in the on-chip data cache for high-performance processors. The key design is that it is programmable so that techniques of software prefetching can be also employed in exploiting the benefits of prefetching. The engine always launches prefetches ahead of current execution, which is controlled by the program counter. We evaluate the proposed scheme by trace-driven simulation and consider area and cycle time factors for the evaluation of cost-effectiveness. Our performance results show that the prefetch engine can significantly reduce data access penalty with only little prefetching overhead.
A numerical investigation of the effect of surface wettability on the boiling curve (2017)

Surface wettability is recognized as playing an important role in pool boiling and the corresponding heat transfer curve. In this work, a systematic study of pool boiling heat transfer on smooth surfaces of varying wettability (contact angle range of 5° - 180°) has been conducted and reported. Based on numerical simulations, boiling curves are calculated and boiling dynamics in each regime are studied using a volume-of-fluid method with contact angle model. The calculated trends in critical heat flux and Leidenfrost point as functions of surface wettability are obtained and compared with prior experimental and theoretical predictions, giving good agreement. For the first time, the effect of contact angle on the complete boiling curve is shown. It is demonstrated that the simulation methodology can be used for studying pool boiling and related dynamics and providing more physical insights.
One-Step Bridgehead Acetamidation of Polycycloalkanes through Bromine Oxidation (1977)

Die Oxidation von Polycycloalkanen mit Brom in Acetonitril in Gegenwart von 95%iger Schwefelsaure bei Raumtemperatur fuhrt in guten Ausbeuten zu N-Polycycloalkyl-acetamiden.
Le pronom 'je' après le verbe: retour sur une postposition insolite (2017)

International audience
Celebrating 50 Years of Macromolecules (2017)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTCelebrating 50 Years of MacromoleculesTimothy P. LodgeCite this: Macromolecules 2017, 50, 24, 9525–9527Publication Date (Web):December 26, 2017Publication History Published online26 December 2017Published inissue 26 December 2017https://pubs.acs.org/doi/10.1021/acs.macromol.7b02507https://doi.org/10.1021/acs.macromol.7b02507editorialACS PublicationsCopyright © 2017 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views5067Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (244 KB) Get e-AlertscloseSUBJECTS:Macromolecules,Polymer science,Polymers Get e-Alerts
<title>Crack detection on a cantilever beam using the nearest approximation method</title> (1995)

This paper deals with determination of damage location and magnitude evaluation by measuring the natural frequencies of a structure. A uniform transverse crack, located on a steel cantilever prismatic beam of rectangular cross section, is used as the model for damage. The crack on the beam is assumed to be open during the transverse vibration of the structure, thus the effect of closing and opening of the crack is ignored in the analysis. Euler-Bernoulli beam behavior is modeled and the damage effect (crack location and depth) is modeled as a torsional spring. The equations of motion of the beam with the crack are developed from Hamilton's principle. The natural frequencies for various crack depths and locations are calculated to establish a collection of failure sets. The response from an actual beam is then compared to the collection of failure sets. The failure set that most nearly approximates the actual response is used to identify the crack location and depth. This method is confirmed with the experimental vibration of a steel cantilever beam. This beam has a single damage location and the damage (crack depth) is increased by fatigue loading. The method is valid as long as the response of any of the failure sets do not overlap into the response of other failure sets. The accuracy of this procedure depends upon the type of failure sets used, (mathematical model to predict response) and the response of the system to the actual failure. The advantages and disadvantages of the method are discussed.
Synthesis and Characterization of Water Stable Uranyl(V) Complexes (2021)

Abstract The importance of uranyl(V) (UO 2 + ) species associated with environmental and geologic applications is becoming increasingly evident, but the tendency of the uranyl(V) cation to disproportionate in water has prevented the isolation of stable complexes. Here we demonstrate that in the presence of the tridentate complexing dipicolinate (dpa 2− ), a ligand highly abundant in soil, the uranyl(V) species can be stabilized and isolated in anoxic basic water. Stable uranyl(V) dipicolinate complexes are readily formed from the reduction of the uranyl(VI) analogue both in organic solution and in basic water, and their solution and solid‐state structure were determined. A bis‐dpa U V O 2 + complex was obtained from water at pH 10, while at higher pH values, a trinuclear mono‐dpa cation‐cation complex was isolated. These results present the second ever isolated water stable uranyl(V) complex. Moreover, we demonstrate that dipicolinate complexes of U VI O 2 2+ , U V O 2 + and U IV are strongly luminescent with a signature characteristic of each oxidation state. This provides unique examples of luminescent U V and U IV compounds.
Studies of Peptide Antibiotics. XIII. Synthesis of Retrogramicidin S (1968)

Abstract In order to investigate a contribution for an antibacterial activity of a direction of the peptide bonds in gramicidin S molecule, retrogramicidin S with the reverse peptide sequence was prepared through a cyclization reaction of linear decapeptide active ester in pyridine. The cyclization of linear pentapeptide active ester yielded a mixture of retrocyclosemigramicidin S and retrogramicidin S. Retrogramicidin S thus obtained exhibited a weak activity against Bacillus subtilis and Staphylococcus aureus, whereas retrocyclosemigramicidin S showed no activity against any of microorganisms tested.
Frequência de esteatose e esteato-hepatite em necropsias por morte violenta em população adulta (2017)

\n INTRODUÇÃO: A Doença Hepática Gordurosa (DHG) é considerada um dos grandes problemas de saúde pública do novo milênio, impulsionada sobretudo pela epidemia de obesidade. Está relacionada com alta morbidade, piora da qualidade de vida e custos econômicos para a sociedade. Existem duas formas histopatológicas iniciais inseridas dentro da DHG: a esteatose e a esteato-hepatite que podem evoluir para cirrose e hepatocarcinoma. A maior parte da literatura sobre epidemiologia da doença hepática gordurosa utiliza desenhos retrospectivos e meios diagnósticos não invasivos, embora o padrão ouro seja a biópsia hepática. Medidas preventivas e de controle adequados deverão ser tomadas baseadas em informações epidemiológicas envolvendo população \\"sadia\\". A excelente correspondência das alterações histopatológicas encontradas no cadáver em relação ao vivo permite extrapolar dados da frequência de esteatose e esteato-hepatite encontradas em uma população jovem vítima de morte violenta para uma população \\"normal\\". Contudo, não há estudo prévio que avalie frequência e fatores preditivos de esteatose e esteatohepatite em fígados de cadáver. O objetivo deste estudo foi avaliar a esteatose e a esteato-hepatite em fígados de adultos vítimas de morte violenta. MÉTODOS: As amostras foram coletadas de 224 adultos submetidos a autópsia forense a partir de setembro de 2011 a abril de 2013. Dados antropométricos e do fígado foram registrados. O exame histopatológico foi realizado em seis amostras obtidas com base em diferentes lóbulos de cada fígado. Cada amostra foi tratada com quatro corantes: hematoxilina-eosina, Perls, pricosirius e tricrômio de Masson. Desfechos de interesse foram a presença de esteatose, esteato-hepatite, fibrose e siderose. RESULTADOS: A amostra apresentou uma média de idade de 40 anos. A esteatose foi diagnosticada em 48,2% dos casos e esteato-hepatite em 2,7%. Uma alta prevalência de fígado gorduroso foi verificada entre homens e indivíduos mais velhos, sendo a faixa etária mais atingida entre 41-60 anos. Os fatores significativamente associados com o aumento do risco de esteatose foram circunferência abdominal (p &lt; 0,001), IMC(p &lt; 0,001), peso do fígado (p=0,002), assim como a presença de siderose (p=0.018). CONCLUSÃO: A alta prevalência de esteatose hepática foi detectada em biópsias pós-morte de uma população jovem. Uma vez que esta doença pode ter consequências clínicas severas, esse dado é importante para avaliar medidas preventivas para a doença hepática gordurosa e suas graves consequências\n