gebhart/patrepeval huggingface dataset:
The presence of cerebral white matter lesions and lower skin microvascular perfusion predicts lower cognitive performance in type 1 diabetes patients with retinopathy but not in healthy controls—A longitudinal study (2019)

Abstract Objective Cognitive impairments in type 1 diabetes may result from hyperglycemia‐associated cerebral microangiopathy. We aimed to identify cerebral microangiopathy and skin microvascular dysfunction—as a surrogate marker for generalized microvascular function—as predictors of cognitive performance over time. Methods In this prospective cohort study, 25 type 1 diabetes patients with proliferative retinopathy and 25 matched healthy controls underwent neurocognitive testing at baseline and after follow‐up (3.8 ± 0.8 years). At baseline, 1.5‐T cerebral magnetic resonance imaging was used to detect WML and cerebral microbleeds. Skin capillary perfusion was assessed by means of capillary microscopy. Results In type 1 diabetes patients, but not in healthy controls, the presence of WML (ß = −0.419; P = 0.037) as well as lower skin capillary perfusion (baseline: ß = 0.753; P &lt; 0.001; peak hyperemia: ß = 0.743; P = 0.001; venous occlusion: ß = 0.675; P = 0.003; capillary recruitment: ß = 0.549; P = 0.022) at baseline was associated with lower cognitive performance over time, independent of age, sex, HbA1c, and severe hypoglycemia. The relationship between WML and lower cognitive performance was significantly reduced after adjusting for capillary perfusion. Conclusions These data fit the hypothesis that cerebral microangiopathy is a manifestation of generalized microvascular dysfunction, leading to lower cognitive performance.
Effect of Controlled Atmospheres and Environmental Conditions on the Physicochemical and Sensory Characteristics of Sweet Cherry Cultivar Satin (2022)

Sweet cherry is a highly appreciated seasonal fruit with a high content of bioactive compounds; however, this highly perishable fruit has a relatively short shelf-life period. Here, we evaluated the evolution of the physicochemical and sensory qualities of sweet cherries (Prunus avium (L.) cv. Satin) under different storage conditions, namely at a Farmers’ Organization (FO) and in a Research Centre (RC) under normal and four different conditions of controlled atmosphere for 49 days. Additional parameters were monitored, such as rotten fruit incidence and stem appearance. Temperature was the factor that most influenced the fruit quality changes over the study time. In fact, fruits stored at higher mean temperatures showed higher weight loss, higher variation in CIE-Lab colour parameters, higher firmness loss, and browner and more dehydrated stems and were less appealing to the consumer. Controlled atmosphere conditions showed a smaller decrease in CIE-Lab colour parameters and lower weight loss. The incidence of rotting was very low and was always equal or lower than 2% for all conditions. Thus, RC chamber conditions were able to sustain fruit quality parameters over 28 days under normal atmosphere conditions and 49 days under controlled atmosphere conditions.
Upper airway chemoreflex responses to saline and water in preterm infants (1988)

Laryngeal chemoreflex (LCR) responses elicited by fluid irrigation of the larynx have been described repeatedly in animals, whereas evidence for a similar reflex in human infants is extremely limited. Using nasopharyngeal catheters to instill small volumes of warm saline or water into the pharynx, we examined the incidence and characteristics of such a reflex in nine premature infants. Saline and water elicited the same pattern of responses, which frequently included swallows, central apnea, and airway obstruction and less commonly featured coughs, prolonged apnea, and arousal. With the exception of arousal, the incidence of these responses was significantly greater after delivery of water stimuli than after saline bolus administration. We therefore deduce chemoreceptor involvement in generation of these reflex responses and propose a laryngeal site for this sensory system, as in animals. Since greater potency of water compared with saline was demonstrable in all the infants studied, we further conclude that most preterm infants possess an upper airway chemoreflex.
Design-space exploration for the Kulisch accumulator (2017)

Floating-point sums and dot products accumulate rounding errors that may render the result very inaccurate. To address this, Kulisch proposed to use an internal accumulator large enough to cover the full exponent range of floating-point. With it, sums and dot products become exact operations. This idea failed to materialize in general purpose processors, as it was considered to slow and/or too expensive in terms of resources. It may however be an interesting option in recon-figurable computing, where a designer may use use smaller, more resource-efficient floating-point formats, knowing that sums and dot products will be exact. Another motivation of this work is that these exact operations, contrary to classical floating point ones, are associative, which enables better compiler optimizations. This work therefore compares, in the context of modern FPGAs, several implementations of the Kulisch accumulator: three proposed by Kulisch, and two novel ones. These architectures are implemented in a VivadoHLS-compliant C++ generator that is fully customiz-able. Comparisons targeting Xilinx's Kintex 7 FPGAs show improvement over Kulisch' proposal in both area and speed. In single precision, compared with a naive use of classical operators , the proposed accumulator runs at similar frequency, consumes 10x more resource in single precision, but reduces the overall latency of a large dot product by 25x while vastly improving accuracy.
Mechanism of glycogenolytic action of histamine in rat hepatocytes (1991)

The mechanism by which histamine induces glycogenolysis was investigated in rat hepatocytes. Histamine induced stimulation of glucose output in hepatocytes in a dose-dependent manner. The maximal effect of the glycogenolytic action of histamine, which was approximately 60% of the maximal glucagon action, was obtained at 10(-6) M. These effects were inhibited by H1 receptor antagonists triprolidine hydrochloride and tripelennamine but not by a H2 receptor antagonist cimetidine. Histamine also increased the activity of phosphorylase a. When 10(-6) M histamine and 5 x 10(-9) M glucagon were added simultaneously, the actions of these two agents were additive. In contrast, there was no additivity when 10(-6) M histamine and 10(-8) M angiotensin II were added. Histamine did not increase adenosine 3',5'-cyclic monophosphate at any doses tested but induced a rapid increase in the cytoplasmic free calcium concentration ([Ca2+]c). Histamine increased [Ca2+]c even in the presence of 1 microM extracellular calcium, an observation suggesting that histamine caused calcium release from an intracellular calcium pool(s). When [3H]inositol-labeled hepatocytes were incubated with histamine, radioactivity in the D-myo-inositol trisphosphate fraction was rapidly increased. These results indicate that histamine acts on rat hepatocytes mainly via H1 receptors and stimulates glycogenolysis by activating the calcium messenger system.
Logic knowledge base refinement using unlabeled or limited labeled data (2010)

In many text mining applications, knowledge bases incorporating expert knowledge are beneficial for intelligent decision making. Refining an existing knowledge base from a source domain to a different target domain solving the same task would greatly reduce the effort required for preparing labeled training data in constructing a new knowledge base. We investigate a new framework of refining a kind of logic knowledge base known as Markov Logic Networks (MLN). One characteristic of this adaptation problem is that since the data distributions of the two domains are different, there should be different tailor-made MLNs for each domain. On the other hand, the two knowledge bases should share certain amount of similarities due to the same goal. We investigate the refinement in two situations, namely, using unlabeled target domain data, and using limited amount of labeled target domain data. 
When there is no manual label given for the target domain data, we re-fine an existing MLN via two components. The first component is the logic formula weight adaptation that jointly maximizes the likelihood of the observations of the target domain unlabeled data and considers the differences between the two domains. Two approaches are designed to capture the differences between the two domains. One approach is to analyze the distribution divergence between the two domains and the other approach is to incorporate a penalized degree of difference. The second component is logic formula refinement where logic formulae specific to the target domain are discovered to further capture the characteristics of the target domain. 
When manual annotation of a limited amount of target domain data is possible, we exploit how to actively select the data for annotation and develop two active learning approaches. The first approach is a pool-based active learning approach taking into account of the differences between the source and the target domains. A theoretical analysis on the sampling bound of the approach is conducted to demonstrate that informative data can be actively selected. The second approach is an error-driven approach that is designed to provide estimated labels for the target domain and hence the quality of the logic formulae captured for the target domain can be improved. An error analysis on the cluster-based active learning approach is presented. We have conducted extensive experiments on two different text mining tasks, namely, pronoun resolution and segmentation of citation records, showing consistent ii improvements in both situations of using unlabeled target domain data, and with a limited amount of labeled target domain data.
Functional granulocyte/macrophage colony stimulating factor receptor is constitutively expressed on neoplastic plasma cells and mediates tumour cell longevity (1998)

It has been shown that granulocyte/macrophage colony stimulating factor (GM-CSF) is able to support myeloma cell propagation in cooperation with interleukin (IL)-6, the major growth factor for malignant plasma cells, although the biological mechanisms involved remain unknown. Therefore we investigated (i) the expression levels of the GM-CSF receptor (GM-CSFR) constituents in three malignant plasma cell lines and in native malignant plasma cells, (ii) the ability of the receptor to mediate common signalling pathways regulating proliferation and cell survival in malignant plasma cell lines, and (iii) the effects of GM-CSF on tumour cell biology. The GM-CSFRalpha subunit was detected in the malignant plasma cell lines RPMI-8226, MC/CAR, IM-9 as well as 6/6 native myeloma cell samples derived from the bone marrow of patients with overt disease. Furthermore, GM-CSFR expression was also detected in the CD19+ fraction from 2/3 bone marrow samples and 5/8 peripheral blood samples derived from patients with malignant plasma cell disorders, but not in the CD19+ fraction of peripheral blood from healthy donors. The expressed cytokine receptor alpha-subunit was able to constitute a functional signalling complex with the ubiquitously expressed GM-CSFRbeta subunit, as demonstrated by the fact that GM-CSF induced the p21-ras/mitogen-activated protein kinase (MAPK) signalling cascade in malignant plasma cell lines. Since this signalling cascade plays an essential role in the mediation of both proliferation and cell survival, we investigated the impact of GM-CSF on these two events. Application of GM-CSF led to an increase of DNA-synthesis in MC/CAR, IM-9 and RPMI-8226 cells. Furthermore, it increased longevity of these malignant plasma cell lines by reducing the rates of spontaneous apoptosis. We conclude that (i) the functional GM-CSFR is commonly expressed on malignant plasma cells and that (ii) GM-CSF promotes the clonal expansion of myeloma cells by inhibiting spontaneous apoptosis and promoting DNA synthesis.
From the Editors (2010)

Microbiology Australia has gone through a major change this year as ASM seeks to contain costs to the Society. Of course many other journals are already online only journals so most readers will be familiar with this format. For Microbiology Australia the change means we have the opportunity to add videos, web links and virtually unlimited supplementary material. We are interested in hearing your stories of how you now use the electronic journal.
Stereoselection in thermal asymmetric Diels-Alder reactions. Electronic vs. steric effects (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselection in thermal asymmetric Diels-Alder reactions. Electronic vs. steric effectsBlanda Stammen, Ulrich Berlage, Richard Kindermann, William S. Sheldrick, Peter Welzel, Wolfgang R. Roth, Manfred Kaiser, and Barbara GuentherCite this: J. Org. Chem. 1992, 57, 24, 6566–6575Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/jo00050a037https://doi.org/10.1021/jo00050a037research-articleACS PublicationsRequest reuse permissionsArticle Views1009Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Monitoring the Progression of Structure–Activity Relationship Information during Lead Optimization (2015)

Lead optimization (LO) in medicinal chemistry is largely driven by hypotheses and depends on the ingenuity, experience, and intuition of medicinal chemists, focusing on the key question of which compound should be made next. It is essentially impossible to predict whether an LO project might ultimately be successful, and it is also very difficult to estimate when a sufficient number of compounds has been evaluated to judge the odds of a project. Given the subjective nature of LO decisions and the inherent optimism of project teams, very few attempts have been made to systematically evaluate project progression. Herein, we introduce a computational framework to follow the evolution of structure-activity relationship (SAR) information over a time course. The approach is based on the use of SAR matrix data structures as a diagnostic tool and enables graphical analysis of SAR redundancy and project progression. This framework should help the process of making decisions in close-in analogue work.
Machine Learning for Better Models for Predicting Bond Prices (2017)

Bond prices are a reflection of extremely complex market interactions and policies, making prediction of future prices difficult. This task becomes even more challenging due to the dearth of relevant information, and accuracy is not the only consideration--in trading situations, time is of the essence. Thus, machine learning in the context of bond price predictions should be both fast and accurate. In this course project, we use a dataset describing the previous 10 trades of a large number of bonds among other relevant descriptive metrics to predict future bond prices. Each of 762,678 bonds in the dataset is described by a total of 61 attributes, including a ground truth trade price. We evaluate the performance of various supervised learning algorithms for regression followed by ensemble methods, with feature and model selection considerations being treated in detail. We further evaluate all methods on both accuracy and speed. Finally, we propose a novel hybrid time-series aided machine learning method that could be applied to such datasets in future work.
Extended Range Performance Model For Thermal Imagers (1988)

Usually, the range performance of thermal imagers is predicted by using the static performance model for thermal imaging systems4 from the Night Vision Laboratory NVL. Most range performance models yield results which are quite similar to the results of the NVL-model. Range-performance measurements with different thermal imagers have proved, that the NVL-model must be modified or extended by following points:-cue-identification-aliasing-vertical MRT-moving images - effective MRT
Metabolic adaptations in brown adipose tissue of the hamster in extreme ambient temperatures (1976)

Cold acclimation caused the following changes in the brown adipose tissue (BAT) of the hamster: the relative weight of the tissue increased, it color darkened, the multilocular structure predominated, and tissue protein content increased while fat content decreased. There was also an increase in the mitochondrial protein content. Heat acclimation had the opposite effects, i.e., the color became lighter, total and mitochondrial protein decreased, fat content increased, and tissue structure was mostly unilocular. Accordingly, cold acclimation was accompanied by increased tissue respiration in the presence of chi-glycerophosphate (chi-GP) and succinate, whereas heat acclimation reduced the respiratory activity of the tissue with these substrates. Isolated BAT mitochondria from cold-acclimated animals increased activities of chi-GP and NADH oxidase, whereas the activities of succinic and cytochrome oxidases and the amount of mitochondrial cytochromes were unchanged. The effects of heat acclimation were more pronounced: there was a decrease in the activities of chi-GP, succinic, NADH, and cytochrome oxidases, as well as in the cytochrome a and a3 content. When respiration of tissue slices on succinate was compared to the maximal potential respiration, as measured with mitochondria disrupted by freezing and thawing, it was found that the relative activity (slices vs. disrupted mitochondria) was highest in cold-acclimated animals and decreased progressively with increasing acclimation temperatures. It is suggested that the differences in the apparent activity of the mitochondria were due to changes in the conformation of the mitochondria as a result of acclimation.
Modern state estimation methods in power systems (2009)

State estimation is an important tool for system operators. The state of the power system is defined by the voltage magnitudes and phase angles at all buses. The state estimator (SE) determines this state based on a set of redundant measurements. The classic steady-state estimator is widely used. Attempts to formulate a dynamic-state estimator have also been made. To speed up the computation, some authors have tried to formulate a distributed SE which can be computed using parallel processing. Recently it became possible to do very accurate synchronized phasor measurements. Now state-of-the-art SE are implemented using data from these measurements. This paper gives an overview of the power system state estimation theory and practise. It is intended to serve as starting point for developing new state estimation techniques.
The α-Macroglobulin Bait Region (1989)

The amino acid sequence of a 90-residue segment of human pregnancy zone protein containing its bait region has been determined. Human alpha 2-macroglobulin, human pregnancy zone protein, and rat alpha 1-macroglobulin, alpha 2-macroglobulin, and alpha 1-inhibitor 3 variants 1 and 2 constitute a group of homologous proteins; but the sequences of their bait regions are not related, and they differ in length (32-53 residues). The alpha-macroglobulin bait region is located equivalently with residues 666-706 in human alpha 2-macroglobulin. In view of the extreme sequence variation of the bait regions, the evolutionary constraints for these regions are likely to differ from those of the remainder of the alpha-macroglobulin structure. The sites of specific limited proteolysis in the bait regions of human pregnancy zone protein and rat alpha 1-macroglobulin, alpha 2-macroglobulin, and alpha 1-inhibitor 3 variants 1 and 2 by a variety of proteinases differing in specificity have been determined and compared with those identified earlier in human alpha 2-macroglobulin. The sites of cleavage generally conform to the substrate specificity of the proteinase in question, but the positions and nature of the P4-P4' sites differ. Most cleavages occur in two relatively small segments spaced by 6-10 residues; and in each case, bait region cleavage leads to alpha-macroglobulin-proteinase complex formation. The rate at which a given proteinase cleaves alpha-macroglobulin bait regions is likely to show great variation. Possible structural features of the widely different bait regions and their role in the mechanism of activation are discussed.
Relationship between carrier-induced index change and feedback noise in diode lasers (1982)

An improved theoretical analysis of single-mode diode laser dynamics reveals that feedback-induced intensity pulsations and frequency modulation are consequences of the carrier-dependent modal refractive index of the laser cavity. A stability criterion based on injection-locking theory indicates that gain-guided diode lasers are more likely to exhibit feedback-induced pulsations than are index-guided devices. Numerical simulation of feedback-induced noise is shown to be in excellent agreement with previously reported experimental data.
Approximate regimes of the H‐F DMO operator (1994)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1994Approximate regimes of the H‐F DMO operatorAuthors: Vigen OhanianConsultantThomas M. SnyderDaniel P. HampsonVigen Ohanian, Thomas M. SnyderLincoln‐Land College, and Daniel P. HampsonHampson Russell Softwarehttps://doi.org/10.1190/1.1822831 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1822831FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1994ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1994 Pages: 1679 publication data© 1994 Copyright © 1994 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Vigen Ohanian, Thomas M. Snyder, and Daniel P. Hampson, (1994), "Approximate regimes of the H‐F DMO operator," SEG Technical Program Expanded Abstracts : 1533-1536. https://doi.org/10.1190/1.1822831 Plain-Language Summary PDF DownloadLoading ...
1.8 petabit/s downstream capacity WDM passive optical network (1997)

We demonstrated the ability to provide 55 Mb/s service to 33.5 million passive optical network (PON) subscribers using an 8-channel sequentially-pulsed 1555 nm integrated multifrequency laser distributed to 4.3 million WDM PON lines through five amplifier/splitter stages. The wavelength-encoded pulses were modulated at 440 Mb/s with an InGaAsP electroabsorption modulator, then after 20 km transmission through single-mode fiber, were demultiplexed with an arrayed-waveguide grating router. Error-free transmission was achieved.
Outcome of pregnancies complicated by severe ovarian hyperstimulation syndrome (OHSS): a follow-up beyond the second trimester (2004)

Although patients with OHSS-complicated pregnancies previously reported a relatively high risk of GDM and PIH, the occurrence rates do not differ from a matched control group of normally responding patients who conceived after IVF.