gebhart/patrepeval huggingface dataset:
Domestic Appliances (1999)

Abstract The sections in this article are Appliance Technology Fuzzy Appliances The Benefits of Fuzzy Logic in Appliances The Negative Side The Future Conclusion
Radiation from an electron beam in magnetized plasma: excitation of a whistler mode wave packet by interacting, higher-frequency, electrostatic-wave eigenmodes (2017)

Infrequent, bursty, electromagnetic, whistler-mode wave packets, excited spontaneously in the laboratory by an electron beam from a hot cathode, appear transiently, each with a time duration around ~1 μs. The wave packets have a center frequency f W that is broadly distributed in the range 7 MHz < f W < 40 MHz. They are excited in a region with separate electrostatic (es) plasma oscillations at values of f hf, 200 MHz < f hf < 500 MHz, that are hypothesized to match eigenmode frequencies of an axially localized hf es field in a well-defined region attached to the cathode. Features of these es-eigenmodes that are studied include: the mode competition at times of transitions from one dominating es-eigenmode to another, the amplitude and spectral distribution of simultaneously occurring es-eigenmodes that do not lead to a transition, and the correlation of these features with the excitation of whistler mode waves. It is concluded that transient coupling of es-eigenmode pairs at f hf such that = can explain both the transient lifetime and the frequency spectra of the whistler-mode wave packets (f W) as observed in lab. The generalization of the results to bursty whistler-mode excitation in space from electron beams, created on the high potential side of double layers, is discussed.
Subchronic Pathobiological Response Following Chronic Repetitive Mild Traumatic Brain Injury in an Aged Preclinical Model of Amyloid Pathogenesis (2018)

Repetitive mild traumatic brain injury (r-mTBI) is a risk factor for Alzheimer disease (AD). The precise nature of how r-mTBI leads to, or precipitates, AD pathogenesis remains unclear. In this study, we explore subchronic effects of chronic r-mTBI (12-impacts) administered over 1-month in aged-PS1/APP mice and littermate controls. We investigate specific mechanisms that may elucidate the molecular link between AD and r-mTBI, focusing primarily on amyloid and tau pathology, amyloid processing, glial activation states, and associated clearance mechanisms. Herein, we demonstrate r-mTBI in aged PS1/APP mice does not augment, glial activation, amyloid burden, or tau pathology (with exception of pS202-positive Tau) 1 month after exposure to the last-injury. However, we observed a decrease in brain soluble Aβ42 levels without any appreciable change in peripheral soluble Aβ42 levels. This was accompanied by an increase in brain insoluble to soluble Aβ42 ratio in injured PS1/APP mice compared with sham injury. A parallel reduction in phagocytic receptor, triggering receptor expressed on myeloid cells 2, was also observed. This study demonstrates very subtle subchronic effects of r-mTBI on a preexisting amyloid pathology background, which may be on a continuum toward a slow and worsening neurodegenerative outcome compared with sham injury, and therefore, have many implications, especially in the elderly population exposed to TBI.
Bioactive 5α-Pregnane-Type Steroidal Alkaloids from Sarcococca hookeriana (2008)

The bioassay-guided phytochemical investigation of Sarcococca hookeriana with respect to cholinesterase inhibitory properties has yielded two new 5alpha-pregnane-type steroidal alkaloids, hookerianamides J (1) and K (2), along with eight known compounds (3-10). The structures of 1 and 2 were elucidated by spectroscopic methods. These compounds displayed good to moderate activities in vitro against the enzymes acetylcholinesterase (IC 50 8.1-48.5 microM) and butyrylcholinesterase (IC 50 0.4-4.0 microM). Compounds 1-10 were also tested in vitro for their leishmanicidal activity against Leishmania major and for their antibacterial activities against Bacillus subtilis, Micrococcus luteus, Streptococcus faecalis, and Pseudomonas pallida.
Targeted Training for Subspecialist Care in Children With Medical Complexity (2022)

Regarding patient safety, this study revealed the heterogeneous aspects and the importance of training future pediatric tertiary care specialists outside their field of expertise involving the multidisciplinary care of CMC. Our results may lay the groundwork for future detailed analysis and development of training boot camps that might be able to aid the improvement of patient safety by decreasing preventable harm by medical errors, especially for vulnerable patient groups, such as CMC in tertiary care pediatrics.
Modified Cycle‐Cast of TNT Based Explosives (1990)

Abstract The gain sizes of TNT‐HNS cast were examined. The results show higher melt temperature of TNT‐HNS mixture produces larger crystals. Based on two assumptions, equilibrium exists among TNT, HNS and nucleant complex 2TNT:HNS, and the dissociation of the nucleant is of endorthermic nature, an one‐stage cycle‐cast process is proposed. This process also yields fine, randomly oriented grain structure as Bofors' cycle‐cast process has claimed.
Direct Amination of Homoenolates Catalyzed by N-Heterocyclic Carbenes (2008)

N-Heterocyclic carbenes derived from N-mesityl-N-methyltriazolium salts are effective catalysts for generating homoenolate species from alpha,beta-unsaturated aldehydes. The unique intermediate adds to the electrophilic nitrogen of 1-acyl-2-aryldiazenes, and the resulting activated carbonyl unit undergoes an intramolecular acylation event. This formal [3+2] cycloaddition between alpha,beta-unsaturated aldehydes and acylaryldiazenes, catalyzed by an N-heterocyclic carbene, produces substituted pyrazolidinones in good yields. This new NHC-catalyzed reaction accommodates aromatic and alkyl alpha,beta-unsaturated aldehydes and various aromatic diazenes. A chiral triazolium salt catalyzes the formation of the pyrazolidinone product in moderate yield and good enantioselectivity. The pyrazolidinones can undergo reductive N-N bond cleavage to give beta-amino acid derivatives.
Near-Optimal Non-Parametric Sequential Tests and Confidence Sequences with Possibly Dependent Observations (2022)

Sequential tests and their implied confidence sequences, which are valid at arbitrary stopping times, promise flexible statistical inference and on-the-fly decision making. However, strong guarantees are limited to parametric sequential tests that under-cover in practice or concentration-bound-based sequences that over-cover and have suboptimal rejection times. In this work, we consider classic delayed-start normal-mixture sequential probability ratio tests, and we provide the first asymptotic type-I-error and expected-rejection-time guarantees under general non-parametric data generating processes, where the asymptotics are indexed by the test's burn-in time. The type-I-error results primarily leverage a martingale strong invariance principle and establish that these tests (and their implied confidence sequences) have type-I error rates asymptotically equivalent to the desired (possibly varying) $α$-level. The expected-rejection-time results primarily leverage an identity inspired by Itô's lemma and imply that, in certain asymptotic regimes, the expected rejection time is asymptotically equivalent to the minimum possible among $α$-level tests. We show how to apply our results to sequential inference on parameters defined by estimating equations, such as average treatment effects. Together, our results establish these (ostensibly parametric) tests as general-purpose, non-parametric, and near-optimal. We illustrate this via numerical simulations and a real-data application to A/B testing at Netflix.
CD1d Activation and Blockade: A New Antitumor Strategy (2009)

CD1d is expressed on APCs and presents glycolipids to CD1d-restricted NKT cells. For the first time, we demonstrate the ability of anti-CD1d mAbs to inhibit the growth of different CD1d-negative experimental carcinomas in mice. Anti-CD1d mAbs systemically activated CD1d(+) APC, as measured by production of IFN-gamma and IL-12. Tumor growth inhibition was found to be completely dependent on IFN-gamma and IL-12 and variably dependent on CD8(+) T cells and NK cells, depending upon the tumor model examined. Anti-CD1d mAb induced greater CD8(+) T cell-dependent tumor suppression where regulatory CD1d-restricted type II NKT cells have been implicated, and were less effective in a NK cell-dependent manner against tumors where T regulatory cells were immunosuppressive. The ability of anti-CD1d mAbs to coincidently activate CD1d(+) APCs to release IL-12 and inhibit CD1d-restricted type II NKT cells makes CD1d an exciting new target for immunotherapy of cancer based on tumor immunoregulation.
Development of a two-dimensional liquid chromatography-tandem mass-spectrometry method for the determination of vitamin D2 in mushrooms (2022)

Different foods, especially mushrooms, are a valuable source of vitamin D2. However, published concentrations in mushrooms show large variabilities. One reason for this is certainly the high biological variability caused by growth conditions, and another could also be found in the analytical methodology. Therefore, this study aimed to develop a sensitive and highly selective two-dimensional liquid chromatography mass spectrometry (LC-MS/MS) method for vitamin D2 analysis in mushrooms. After validation, the method was applied to four different mushroom species. The developed method with a one-step extraction procedure showed a limit of detection of 0.01 µg vitamin D2/g dry mass (DM), a limit of quantification of 0.05 µg vitamin D2/g DM, and recovery rates between 87.6 and 94.8%. The total run time including the re-equilibration of the columns for the next injection was 7.5 min. After adding increased concentrations of pure substance to Pleurotus ostreatus, Lentinula edodes, and brown and white button mushrooms the standard addition plot showed excellent correlation coefficients (R<sup>2</sup>) of > 0.9994. Mean vitamin D2 concentrations were observed at 0.122 ± 0.007, 0.074 ± 0.005, 0.099 ± 0.007, and 0.073 ± 0.005 µg/g DM. The coefficient of variation (CV) was between 5.1 and 7.6%. This well-optimized, sensitive LC-MS/MS method, with a fast and simple sample preparation and a short run time, can be applied to future studies especially in different mushroom species with variable growing conditions. This will improve our knowledge about the vitamin D2 content in mushrooms.
A comparative study of the effect of addition of CeO x and Li2O on γ-Al2O3 supported copper, silver and gold catalysts in the preferential oxidation of CO (2007)

In the study described in this paper we deposited gold, silver and copper on γ-Al2O3 as nanoparticles (<4 nm) and investigated the behavior of these nanoparticles in the preferential oxidation of CO in presence of H2. In addition, the effect of addition of CeO x and/or Li2O was investigated. All the three metals show preferential oxidation of CO at low temperatures. The oxides added to Au/γ-Al2O3, Ag/γ-Al2O3 and Cu/γ-Al2O3 improve the catalytic performance of the gold, silver and copper. Interesting and synergistic effects were observed when both the CeO x and Li2O were added. Possible mechanisms are proposed.
Dendrimer–silica hybrid mesoporous materials (2011)

Dendrimers and silica inorganic materials are two effective building blocks that have attracted growing interest in both fundamental and applied material chemistry. The fruitful association of these soft and hard skeletons resulted in an unlimited library of materials and nanodevices with different tailored properties. The aim of this review is to shed light on different strategies of combination of dendrimer–silica materials. Special attention has been accorded to the porosity control and the accessibility of the functional groups of these organic–inorganic hybrid mesoporous materials.
Selection of stable features for modeling 4-D affective space from EEG recording (2017)

Recent advances in neuroscience made it possible to understand how the human brain processes emotions and affective states. However, the modeling of emotion remains elusive due to inherent ambiguity and complexity related to the perception of emotions, interpersonal variabilities, and context-specific interpretations. Here, we present a robust method of modeling 4-D continuous affective space (Valence, Arousal, Like, and Dominance). First, we determined the functional areas and frequency bands related to 4-D affective space. Second, we extracted and selected a set of stable features. For both steps, we used two different feature selection methods namely: Recursive Feature Elimination (RFE) and stability selection method. Moreover, compare their performances. For the RFE, we used Random Forest (RF), Support Vector Regression (SVR), Tree-based bagging, and for the stability selection, we used Randomized Lasso as an estimator. Empirical analysis on the DEAP data set shows that the stability selection method consistently provides relevant set of bands, electrode location and features over a range of model parameters. We also observed that only a small number of locations (40%–63%) and certain frequency bands specifically, gamma band frequency over Superior Temporal Gyrus, Supramarginal Gyrus, and Somatosensory Association Cortex were the highest ranked features across the affective dimensions. The selected features using the stability criteria were used to model 4-D affective space using SVR. Empirical analyses shows that the Root Mean Square Error (RMSE) for Valence, Arousal, Dominance, and Like are 2.13, 2.00, 2.07, and 2.11 respectively. In addition, we also compare the performance of this method with feature fusion and ensemble classification. It was observed that the SVR with selected features outperformed all other approaches. The predicted Valence-Arousal-Dominance were converted to categorical emotions for seamless interpretation.
Supplementary Figure 12 from MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells (2023)

&lt;p&gt;PDF file, 149K, Supplementary Figure S12. RGD Peptide Directed Delivery of Anti-miRs using Liposomes.&lt;/p&gt;
Narrow-band ultraviolet B (NB UV-B) exposures improve mood in healthy individuals differently depending on chronotype (2019)

The evening chronotype is associated with psychological symptoms such as depressed mood, while skin exposure to ultraviolet radiation (UVR) may affect mood and behavior through neural and humoral routes. This pilot study aimed to investigate the impact of whole-body narrow-band (NB) UV-B exposure on current mood state and circulating 25-hydroxyvitamin D3 (25(OH)D<sub>3</sub>), interleukin-6 (IL-6), cortisol and β-endorphin (β-END) levels in healthy participants. Here, eleven healthy women received full-body NB UV-B exposures on four afternoons, and the chronotype was assessed with a shortened version of Horne and Östberg's Morningness-Eveningness Questionnaire (MEQ). Perceived mood was evaluated using the Visual Analogue Scale (VAS), and serum 25(OH)D<sub>3</sub>, IL-6, cortisol and β-END concentrations were monitored daily. Decreasing VAS values showed mood to improve significantly over the five days after the four suberythematous NB UV-B exposures (<i>p</i> = .038), and the more the circadian preference was inclined toward eveningness, the greater the improvement in the mood dimension of wellbeing (<i>p</i> = .021). Baseline mood state was correlated with baseline 25(OH)D<sub>3</sub> (r = -0.54, 95% CI: -0.86 to -0.09) and with baseline cortisol (r = -0.57, 95% CI: -0.87 to -0.04). During the NB UV-B exposures, 25(OH)D<sub>3</sub> increased significantly, as expected, and IL-6 declined significantly by -0.35 (95% CI: -0.69 to -0.07) pg/mL from the initial values of 1.12 ± 0.66 pg/mL (<i>p</i> = .025). In conclusion, in our pilot study, NB UV-B exposure improved mood, especially among those with evening preference for their daily activities, as well as circulating 25(OH)D<sub>3</sub> levels, whereas circulating IL-6 levels decreased. <b>Abbreviations:</b> UVR: Ultraviolet radiation; NB UV-B: narrow-band UV-B; VAS: Visual Analogue Scales; β-END: β-endorphin; IL-6: Interleukin-6.
Acute hepatitis associated with the use of natural product camu-camu (2013)

A 45-year-old previously healthy caucasian man was admitted for pruritus, scleral icterus and dark urine. The patient was reported to have taken a spoon of a preparation containing camu-camu (myrciaria dubia) a day. He took no other drugs and did not drink alcohol or use illicit substance. Laboratory studies reveiled an elevated aspartate transaminase of 403 U/L, and alanine transaminase of 1185 U/L, alkalinephosphatase of 335 U/L, gamma glutamyl transpeptidase of 300 U/L, and elevated total bilirubin of 142 μmol/L. His complete blood count was normal. Tests for viral, metabolic or autoimmune causes of liver injury were negative. Liver biopsy demonstrated centrilobular hepatocellular damage was compatible with drug toxicity which was not of very recent origin. Clinical and laboratory signs of liver injury gradually improved and the patient was discharged. Myrciaria dubia is used as a dietary supplement with antioxidant properties. To our knowledge, this is the first report of liver injury probably related to use of camu-camu. Exclusion of other causes and the histological diagnosis were compatible with drug toxicity render camu-camu which was most likely as the cause of acute heaptitis most likely. It is important to increase the awareness of both clinicians and patients about the potential dangers of herbal remedies in absence of reliable studies of clinical efficacy and benefit-risk assessment.
Automated Left Ventricular Segmentation in Cardiac MRI (2006)

We present an automated left ventricular (LV) myocardial boundary extraction method. Automatic localization of the LV is achieved using a motion map and an expectation maximization algorithm. The myocardial region is then segmented using an intensity-based fuzzy affinity map and the myocardial contours are extracted by cost minimization through a dynamic programming approach. The results from the automated algorithm compared against the experienced radiologists using Bland and Altman analysis were found to have consistent mean bias of 7% and limits of agreement comparable to the inter-observer variability inherent in the manual method.
A Novel Additively-Manufactured Pressure Transducer for Zero-Power Wireless Sensing (2022)

This work presents a pressure transducer consisting of a 3D coupled-line directional coupler, where the distance between lines varies with the applied pressure. In particular, two quarter-wave microstrip lines facing each other are aligned one on top of the other so that part of the signal flowing in one line is coupled to the other line. When pressure is applied, the distance between lines reduces, while coupling increases. That way, different pressure levels are converted into different coupling values. Two parallel-plate waveguides connect the microstrip line on the top layer to the bottom layer, so that all four ports of the directional coupler are realized on the same layer. The circuit is manufactured with stereolithography 3D printing. Selective metallization is performed embossing the desired patterns on the 3D printed dielectric and then applying silver nanoparticle ink to the protruding areas with a brush. A proof-of-concept prototype, working at 3 GHz, was manufactured and tested. The proposed prototype features a change of the transmission coefficient between the input and the coupled ports from −15.6 dB to −12.4 dB for an applied pressure of 278 kPa compared to zero pressure state, thereby proving the working principle of the circuit. The proposed transducer can be used in a harmonic transponder, and the pressure information can be retrieved from the amplitude difference of the signals at the direct and coupled ports. The obtained results open the door to a new class of pressure transducers that are based on additively-manufactured radio-frequency components, and are suitable for passive wireless sensors.
A structural induction theorem for processes (1989)

Article Free Access Share on A structural induction theorem for processes Authors: R. P. Kurshan AT&T Bell Laboratories, Murray Hill, NJ AT&T Bell Laboratories, Murray Hill, NJView Profile , K. McMillan Carnegie Mellon University, Pittsburgh, PA Carnegie Mellon University, Pittsburgh, PAView Profile Authors Info & Claims PODC '89: Proceedings of the eighth annual ACM Symposium on Principles of distributed computingJune 1989 Pages 239–247https://doi.org/10.1145/72981.72998Online:01 June 1989Publication History 121citation550DownloadsMetricsTotal Citations121Total Downloads550Last 12 Months19Last 6 weeks5 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Supplementary Figure Legends from Enhancement of Cancer Radiation Therapy by Use of Adenovirus-Mediated Secretable Glucose-Regulated Protein 94/gp96 Expression (2023)

Supplementary Figure Legends from Enhancement of Cancer Radiation Therapy by Use of Adenovirus-Mediated Secretable Glucose-Regulated Protein 94/gp96 Expression
Supplemental Table S2 from The Histone Demethylase Jumonji Coordinates Cellular Senescence Including Secretion of Neural Stem Cell–Attracting Cytokines (2023)

&lt;p&gt;Table S2. Lists of genes defining IPA analyses of "Cancer"- and "Inflammatory response"-related, and those common to both.&lt;/p&gt;
Studies on the Golf Swing : 8th Report, Study on A New 2-link Model (2004)

This paper aims at addressing the dynamic simulation capability of the three different types of the two dimensional double pendulum models for the golf swing. In the studies on the golf swing motion, there is no discussion about the dynamic simulation capability of the model. Comparing with the simulation results for the four intermediate level golfers and three advanced level golfers by using the three models, the influence of the difference of the simulation models on the required torques of the neck and wrist joints are discussed here. The results show the same dynamic simulation capability of the three models. The difference of the golfer's level can be evaluated by the time variation of the distance between the neck and wrist joints during the downswing.