gebhart/patrepeval huggingface dataset:
Development of Dementia, Including Assessment and Interventions (2021)

Adults with Down syndrome show premature aging with a high risk of developing dementia, specifically Alzheimer’s disease. Dementia in people with Down syndrome develops in addition to pre-existing intellectual disability, which poses difficulties in its diagnosis. Determining baseline function and conducting regular assessments are essential to detecting cognitive and functional decline. Comorbid conditions such as epilepsy and depression may also affect dementia presentation. As there is little evidence for effective pharmacological treatment of dementia in adults with Down syndrome, the identification of novel treatment targets is vital. In addition, a better understanding of the time course of the development of dementia will aid in better detection and monitoring of individuals showing early signs of cognitive decline. Early dementia-related changes may include prominent declines in behavior, personality disturbance, and early impairments in memory. Advances in neuroimaging and biomarker detection will further assist in understanding the time course of dementia development in people with Down syndrome.
Ethylene–Propylene Copolymerisations: Effect of Metallocene Structure on Termination Reactions and Polymer Microstructure (2005)

Abstract Summary: Ethylene–propylene (EP) copolymerisations were performed with two sterically different metallocenes activated by methylaluminoxane (MAO) in an attempt to better understand the effect of catalyst structure on termination reactions and polymer microstructure. The metallocene precursors under investigation were rac ‐dimethylsilylbis(2‐methyl‐4‐phenyl‐1‐indenyl)zirconium dichloride ( 1 ) and a more sterically hindered counterpart rac ‐dimethylsilylbis(2‐isopropyl‐4‐[3,5‐dimethylphenyl]indenyl) zirconium dichloride ( 2 ). For both catalyst systems, the most common termination mechanism was chain transfer to aluminium. In addition, for polymer samples polymerised with 1 /MAO, chain growth was terminated by chain transfer to Zr metal in propylene‐rich polymerisations and by chain transfer to ethylene monomer in ethylene‐rich polymerisations. The steric hindrance of 2 was able to suppress the chain transfer to the ethylene monomer, and chain transfer to Zr metal was also found in the ethylene‐rich polymerisations. The greater steric hindrance of 2 also affected the EP copolymer microstructure: regioregularity in the propylene‐rich copolymers was greater and isotacticity less with 2 /MAO than with 1 /MAO. The catalyst precursors used: rac ‐dimethylsilylbis(2‐methyl‐4‐phenyl‐1‐indenyl)zirconium dichloride ( 1 ) and rac ‐dimethylsilylbis(2‐isopropyl‐4‐[3,5‐dimethylphenyl]indenyl) zirconium dichloride ( 2 ). magnified image The catalyst precursors used: rac ‐dimethylsilylbis(2‐methyl‐4‐phenyl‐1‐indenyl)zirconium dichloride ( 1 ) and rac ‐dimethylsilylbis(2‐isopropyl‐4‐[3,5‐dimethylphenyl]indenyl) zirconium dichloride ( 2 ).
Effect of Varying Atrial Sensitivity, AV Interval, and Detection Algorithm on Automatic Mode Switching (1996)

(1) In atrial fibrillation, effective AMS requires more sensitive atrial settings than in NSR; (2) AV intervals as short as 120 ms can interfere with AMS function; and (3) More stringent detection algorithms may be inappropriate for effective AMS function.
Machine-learning model derived gene signature predictive of paclitaxel survival benefit in gastric cancer: results from the randomised phase III SAMIT trial (2021)

UMIN Clinical Trials Registry: C000000082 (SAMIT); ClinicalTrials.gov identifier, 02628951 (South Korean trial).
Fluorescence and chemiluminescence properties of indolylmaleimides: experimental and theoretical studies (2010)

Various indolylmaleimides (IMs) were synthesized, and their fluorescence (FL) and chemiluminescence (CL) were measured. The substitution at the 2-position of the indole ring and the 3- or 4-position of the maleimide moiety caused an obvious change in the FL and CL of the IMs. An almost on-off switching of the FL of the IMs was observed. The intramolecular charge transfer from the indole moiety to the maleimide moiety occurred in 3-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione. In the FL of the IMs, CASPT2 calculations showed deprotonation of the NH group of the indole ring and the maleimide moiety at the excited state. The C[double bond, length as m-dash]C bond in the maleimide moiety was needed for strong CL in the IMs without substitution at the 2-position of the indole ring. The relationships between the FL or CL properties and the structures of the IMs were clarified. These results provide significant information on the rational design of IMs as FL and CL probes.
Influences of Temperature and Oxygen Partial Pressure on Mechanical Properties of La 0.6 Sr 0.4 Co 1− y Fe y O 3−δ (2012)

Young's and shear moduli and Poisson's ratio of La 0.6 Sr 0.4 Co 0.2 Fe 0.8 O 3−δ ( LSCF 6428), La 0.6 Sr 0.4 Co O 3−δ ( LSC ), and La 0.6 Sr 0.4 FeO 3−δ ( LSF ) were investigated in the temperature range from room temperature to 1173 K and in the oxygen partial pressure, P ( O 2 ), range from 1 × 10 −1 to 1 × 10 −4 bar by the resonance method. The Young's and the shear moduli decreased with increasing temperature at low temperatures and drastically increased at intermediate temperatures. The drastic increase was associated with the second‐order phase transition. In contrast, the Poisson's ratios of LSCF 6428, LSC , and LSF decreased around the phase transition temperature. The P ( O 2 ) dependence of the Young's and the shear moduli of LSCF 6428 showed different tendencies depending on temperature. At 873 K, the Young's and the shear moduli were almost independent of P ( O 2 ), whereas they increased with decreasing P ( O 2 ) at 973 K. At 1073 K, they first increased with decreasing P ( O 2 ) under higher P ( O 2 ) and then gradually decreased under lower P ( O 2 ). At 1173 K, they monotonically decreased with decreasing P ( O 2 ). Such complicated P ( O 2 ) dependence were interpreted by complex influences of the phase transition, the chemical expansion and the variation of the oxygen nonstoichiometry and the cation mean valence.
Kardiopulmonale Interaktionen: Kardiovaskuläre Erkrankungen und COPD (2009)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Development of portable sensor for the detection of bacteria: effect of gold nanoparticle size, effective surface area, and interparticle spacing upon sensing interface (2023)

In this study, systematic development of a portable sensor for the rapid detection of Escherichia coli (E. coli) and Exiguobacterium aurantiacum (E. aurantiacum) was reported. A conductive glass was utilized as a substrate and developed the electrode patterns on it. Trisodium citrate (TSC) and chitosan-stabilized gold nanoparticles (AuNPs) (CHI-AuNP-TSC) and chitosan-stabilized AuNPs (CHI-AuNP) were synthesized and utilized as a sensing interface. The morphology, crystallinity, optical properties, chemical structures, and surface properties of immobilized AuNPs on the sensing electrodes were investigated. The sensing performance of the fabricated sensor was evaluated by using an electrochemical method to observe the current changes in cyclic voltammetric responses. The CHI-AuNP-TSC electrode has higher sensitivity toward E. coli than CHI-AuNP with a limit of detection (LOD) of 1.07 CFU/mL. TSC in the AuNPs synthesis process played a vital role in the particle size, the interparticle spacing, the sensor's effective surface area, and the presence of CHI around AuNPs, thus enhancing the sensing performance. Moreover, post-analysis of the fabricated sensor surface exhibited the sensor stability and the interaction between bacteria and the sensor surface. The sensing results showed a promising potential for rapid detection using a portable sensor for various water and food-borne pathogenic diseases.
Enhancing the Electrochemical Performance of Aqueous Processed Li‐Ion Cathodes with Silicon Oxide Coatings (2023)

Lithium-ion battery cathode materials suffer from bulk and interfacial degradation issues, which negatively affect their electrochemical performance. Oxide coatings can mitigate some of these problems and improve electrochemical performance. However, current coating strategies have low throughput, are expensive, and have limited applicability. In this article, we describe a low-cost and scalable strategy for applying oxide coatings on cathode materials. We report synergistic effects of these oxide coatings on the performance of aqueously processed cathodes in cells. The SiO<sub>2</sub> coating strategy developed herein improved mechanical, chemical, and electrochemical performance of aqueously processed Ni-, Mn- and Co-based cathodes. This strategy can be used on a variety of cathodes to improve the performance of aqueously processed Li-ion cells.
Alcoholism: The Influence of Parental Illness (1971)

Alcoholism is associated with a high family incidence of both alcoholism and affective disorder (1). First degree male relatives of alcoholic probands have a 50 per cent lifetime expectancy for alcoholism, while first degree female relatives have a 50 per cent lifetime expectancy for affective disorder (1). Children of alcoholic parents raised with that parent show no higher, and perhaps less, alcoholism than children of alcoholic parents raised separately (2). This paper looks at the influence of parental alcoholism or affective disorder on the characteristics of alcoholism in probands, their progeny and siblings.
InGaN-AlInGaN multiquantum-well LEDs (2001)

InGaN-GaN and InGaN-AlInGaN multiquantum-well (MQW) light-emitting diodes (LEDs) were both fabricated and their optical properties were evaluated by photoluminescence (PL) as well as electroluminescence (EL). We found that the PL peak position of the InGaN-AlInGaN MQW occurs at a much lower wavelength than that of the InGaN-GaN MQW. The PL intensity of the InGaN-AlInGaN MQW was also found to be larger. The EL intensity of the InGaN-AlInGaN MQW LED was also found to be larger than that of the InGaN-GaN MQW LED under the same amount of injection current. Furthermore, it was found that EL spectrum of the InGaN-AlInGaN MQW LED is less sensitive to the injection current. These observations all suggest that we can improve the properties of nitride-based LEDs by using AlInGaN as the barrier layer.
Electronic structure and electrochemical properties of the h4−h8 bis (cyclooctatetraene) vanadium (1995)

The h4−h8 bis (cyclooctatetraene) vanadium is a ‘‘sandwich’’ complex with 17 électrons on the external shell of the metallic atom. It presents two types of carbon‐vanadium bonding. One cycle is bonded to the metal by eight carbon atoms, the other one by four carbon atoms only. EPR and ENDOR measurements have shown that this complex exhibits a strong fluxionality in frozen solution down to 30°K. Moreover, cyclic voltametry experiments reveals two oxydation waves. This fact is suprising since the number of electrons in the external shell of such oxydized complexes move away from 18. A study of the geometries and the electronic structures of these complexes has been undertaken using a local density functional technique. These results have been checked by comparison with data obtained from X‐ray diffraction and ENDOR spectra: the optimized geometries are very close to what is found in the solid state and the existence of two types of V‐carbon bonds is confirmed. Moreover the spin densities calculated for hydrogen atoms by LDF fairly coincide with ENDOR data. The LDF study of V(cot)+2 and V(cot)++2 cations allowed an interpretation of the existence of the two oxydation waves: a structural and electronic modification of the complex occurs that maintains close to 18 the number of electrons in the vanadium external shell.
Achieving High Rate Completions with Innovative Thru-Tubing Sand Control (2001)

Abstract An improved through-tubing sand control technique was utilized recently to enhance reservoir recovery and improve life-cycle economics. This coiled tubing-conveyed method uses several technical innovations that improve the reliability of the vent screen sand control completion. The innovations can be shown to: (1) improve the rate at which reserves can be recovered; (2) improve completion efficiency; (3) reduce mechanical risk; (4) reduce completion costs; (5) extend the economic life of the well; and (6) control fines migration.
DRAM Bandwidth Optimal Perspective Transform Engine (2021)

Perspective transform (or Homography) is commonly used algorithms in ADAS and Automated Driving System. Perspective transform is used in multiple use-cases e.g. viewpoint change, fisheye lens distortion correction, chromatic aberration correction, stereo image pair rectification, This algorithm needs high external DRAM memory bandwidth due to inherent scaling, resulting in nonaligned two dimensional memory burst accesses, resulting in large degradation in system performance and latencies. In this paper, we propose a novel perspective transform engine to reduce external memory DRAM bandwidth to alleviate this problem. The proposed solution consists of multiple regions slicing of input video frame with block size tuned for each region. The paper also gives an algorithm for finding optimal region boundaries with corresponding block size tuned for each region. The proposed solution enables average BW reduction of 67% compared to traditional implementation and achieves clock up-to 720 MHz with output pixel throughput of 1 cycle/pixel in 16nm FinFET process node.
Variable Suppression of Serum Thyroxine in Female Mice of Different Inbred Strains by Triiodothyronine Administered in Drinking Water (2010)

Our data provide important, practical information for future in vivo studies in inbred mice: we recommend that responses to TSH be performed in female animals injected with L-T3 i.p. to suppress baseline T4.
ChemInform Abstract: Antiinflammatory Principles and Three New Labdane‐Type Diterpenes Hedychilactones A, B, and C, from the Rhizome of Hedychium coronarium Koeng. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Hierarchical Deep Domain Adaptation Approach for Fault Diagnosis of Power Plant Thermal System (2019)

Fault diagnosis of a thermal system under varying operating conditions is of great importance for the safe and reliable operation of a power plant involved in peak shaving. However, it is a difficult task due to the lack of sufficient labeled data under some operating conditions. In practical applications, the model built on the labeled data under one operating condition will be extended to such operating conditions. Data distribution discrepancy can be triggered by variation of operating conditions and may degenerate the performance of the model. Considering the fact that data distributions are different but related under different operating conditions, this paper proposes a hierarchical deep domain adaptation (HDDA) approach to transfer a classifier trained on labeled data under one loading condition to identify faults with unlabeled data under another loading condition. In HDDA, a hierarchical structure is developed to reveal the effective information for final diagnosis by layerwisely capturing representative features. HDDA learns domain-invariant and discriminative features with the hierarchical structure by reducing distribution discrepancy and preserving discriminative information hidden in raw process data. For practical applications, the Taguchi method is used to obtain the optimized model parameters. Experimental results and comprehensive comparison analysis demonstrate its superiority.
Serological humoral immunity following natural infection of children with high burden gastrointestinal viruses (2023)

Acute gastroenteritis (AGE) is a major cause of morbidity and mortality worldwide, resulting in an estimated 440,571 deaths of children under age 5 annually. Rotavirus, norovirus, and sapovirus are leading causes of childhood AGE. A successful rotavirus vaccine has reduced rotavirus hospitalizations by more than 50%. Using rotavirus as a guide, elucidating the determinants, breath, and duration of serological antibody immunity to AGE viruses, as well as host genetic factors that define susceptibility is essential for informing development of future vaccines and improving current vaccine candidates. Here, we summarize the current knowledge of disease burden and serological antibody immunity following natural infection to inform further vaccine development for these three high-burden viruses.
Parallel architecture for high-speed Lempel-Ziv data coding/decoding (1998)

Along with progress in computers and network techniques, it is necessary to ensure that the transmission and storage of quantities of information be made more efficient. To solve this problem, many data compression techniques have been developed and applied in various fields. A speed-up of data processing is required in various systems that handle large quantities of information. However, it will be difficult to satisfy the requirement to speed up data compression by software or in a single CPU. Thus, it is desirable to create high-speed data compression/decompression hardware using VLSI/ULSI techniques. In this paper, the parallel architecture PAHL-C is proposed to implement an LZ77 coding algorithm, one of the most effective coding algorithms for various kinds of information. PAHL-C is designed to accelerate data compression. It improves the throughput of data compression by reducing redundancy in the search for the longest matching string of symbols, a task that requires most computation time in LZ77 coding. PAHL-C is designed in logic circuitry by using the PARTHENON high-level synthesis system and its performance is evaluated. We find that the throughput is about 20 or 25 MByte/s. Furthermore, the PAHL-D LZ77 decoding parallel architecture is proposed and its performance is evaluated. It is shown that PAHL-C and PAHL-D can be integrated into a PAHL system effectively. © 1998 Scripta Technica, Syst Comp Jpn, 29(8): 28–37, 1998
Three-Dimentional Optical Storage Medium Using Arranged Nano-spheres (2008)

In this study, we have developed a multi-layered optical storage medium with nano-spheres as the recording medium. We made a three-layered medium of spheres and thereby realized a three-dimensional high-density optical storage system. Using a reflection confocal optical system, we read out clock signals from the medium. The system records data and reconstructs it jitter-free.
Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases (2017)

A large diversity of 2-aminoimidazolone alkaloids is produced by various marine invertebrates, especially by the marine Calcareous sponges <i>Leucetta</i> and <i>Clathrina</i>. The phylogeny of these sponges and the wide scope of 2-aminoimidazolone alkaloids they produce are reviewed in this article. The origin (invertebrate cells, associated microorganisms, or filtered plankton), physiological functions, and natural molecular targets of these alkaloids are largely unknown. Following the identification of leucettamine B as an inhibitor of selected protein kinases, we synthesized a family of analogues, collectively named leucettines, as potent inhibitors of DYRKs (dual-specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) and potential pharmacological leads for the treatment of several diseases, including Alzheimer's disease and Down syndrome. We assembled a small library of marine sponge- and ascidian-derived 2-aminoimidazolone alkaloids, along with several synthetic analogues, and tested them on a panel of mammalian and protozoan kinases. Polyandrocarpamines A and B were found to be potent and selective inhibitors of DYRKs and CLKs. They inhibited cyclin D1 phosphorylation on a DYRK1A phosphosite in cultured cells. 2-Aminoimidazolones thus represent a promising chemical scaffold for the design of potential therapeutic drug candidates acting as specific inhibitors of disease-relevant kinases, and possibly other disease-relevant targets.
Abstract 15507: Effect of Intensive Blood Pressure Control on Residual Lifespan in the SPRINT Trial (2019)

Background: SPRINT (Systolic Blood Pressure Intervention Trial) showed that intensive blood pressure (BP) control (systolic BP target <120mmHg) was superior to standard BP control (<140mmHg), reduc...
Purification of an H+-Translocating Inorganic Pyrophosphatase from Vacuole Membranes of Red Beet (1989)

An H(+)-translocating inorganic pyrophosphatase (PPase) was isolated and purified from red beet (Beta vulgaris L.) tonoplast. One major polypeptide of molecular weight 67 kilodalton copurified with fluoride-inhibitable PPase activity when subjected to one-dimensional polyacrylamide gel electrophoresis. Overall, a 150-fold purification of the PPase was obtained, from the tonoplast fraction, through anion exchange chromatography of the detergent-solubilized membranes followed by ammonium sulfate precipitation and gel filtration chromatography. The purified polypeptide showed no cross-reactivity with antibodies raised against the 67 kilodalton subunit of the tonoplast ATPase.
Association between air quality satisfaction, family relationships, and depression symptoms among middle-aged and elderly chinese people: the mediation role of perceived health status (2022)

Family relationships, air quality satisfaction, and perceived health status influenced depression symptoms. The effects of family relationships and air quality satisfaction on depression symptoms were significantly mediated by perceived health status. Therefore, perceived health status aspects should be considered when conducting targeted intervention toward depression symptoms among middle-aged and elderly adults.
PROPOSAL OF DETECTION METHOD OF TRAFFIC FAULT UNDER LARGE-SCALE DISASTER BY PROBE VEHICLE TRAJECTORY (2018)

現状，大規模災害時の交通障害の把握は，CCTVや巡視員の目視による把握が主となっており，監視箇所が限定されるという課題がある．そこで，本研究では三次元（時間×二次元空間）のプローブ軌跡データを用いて，大規模災害時に広範囲かつ，リアルタイムに道路ネットワーク全体の交通障害を検出する手法を提案した．具体的には，熊本地震時の被災状況と三次元プローブ軌跡データの特徴を分析した．その特徴を踏まえ，平常時と災害時にリアルタイムに収集される三次元プローブ軌跡データの類似度算出から交通障害による異常な挙動の車両を検出する手法を提案した．手法検証の結果，三次元プローブ軌跡データのみで異常車両を検出し，交通障害の検出可能性を示した．
Therapy with a Combination of Low Doses of Interleukin 12 and Chloroquine Completely Cures Blood-Stage Malaria, Prevents Severe Anemia, and Induces Immunity to Reinfection (1999)

The immunoregulatory cytokine interleukin 12 (IL-12) induces host resistance against experimental malaria. In this study, we tested the feasibility of using IL-12 in combination with chloroquine (CQ) to rescue susceptible A/J mice from lethal blood-stage Plasmodium chabaudi AS infection. Combined treatment with low doses of CQ and IL-12 resulted in a >15-fold reduction in the parasite load and 100% survival of A/J mice with established infections. Compared to control mice, which succumbed to severe anemia, CQ-plus-IL-12-treated mice had significantly higher early- and late-stage erythroid-cell progenitors in the bone marrow and spleen, resulting in significantly higher hematocrits, erythrocyte counts, and percentages of reticulocytes. Production of parasite-specific gamma interferon (IFN-gamma) by splenocytes from these mice was upregulated >20-fold relative to controls in parallel with enhanced IFN-gamma mRNA expression. Further, enhanced responsiveness to IL-12 and increased downstream IFN-gamma production in CQ-plus-IL-12-treated mice was evident from increased mRNA expression for the beta1 and beta2 subunits of IL-12 receptor in the splenocytes. Moreover, this combined therapy induced higher levels of anti-malaria antibodies than did CQ alone as well as sterile immunity against reinfection. Because IL-12 can be used at low doses and is effective even in established infections, it may be feasible to use this immunochemotherapeutic approach in human malaria.