gebhart/patrepeval huggingface dataset:
Additive antitumour effect of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) and the antioestrogen fulvestrant (Faslodex, ICI 182,780) in breast cancer cells (2004)

A high expression level of epidermal growth factor receptor (EGFR)/HER1 has been suggested to lead to a shorter survival time and resistance to endocrine therapy in patients with breast cancer. To test the hypothesis that inhibition of the EGFR signalling pathway affects the antitumour effect of endocrine therapy, an EGFR tyrosine kinase inhibitor (EGFR-TKI), gefitinib, and an oestrogen receptor (ER) antagonist, fulvestrant, were administered to human breast cancer cells. A total of five human breast cancer cell lines were used. The effects of single or combined treatments with gefitinib and/or fulvestrant on cell growth, cell cycle progression and apoptosis were analysed. Changes in the expression levels of cyclin-dependent kinase inhibitors, p21 and p27, an antiapoptotic factor, Bcl-2, and a proapoptotic factor, Bax, were also investigated. All cell lines tested were sensitive to gefitinib (50% growth inhibitory concentration, 10-28.5 microM). Breast cancer cell lines with a high expression level of HER1 or HER2 were more sensitive to gefitinib than the others. Gefitinib induced a significant G1-S blockade in ER-positive KPL-3C cells. Gefitinib induced significant apoptosis in HER1-overexpressing MDA-MB-231 cells. Gefitinib additively increased the antitumour effect of fulvestrant in all three ER-positive cell lines in a medium supplemented with 17beta-oestradiol. The combined treatment promoted cell cycle retardation in KPL-3C cells, which is associated with an upregulation of p21 by fulvestrant and gefitinib, respectively. Apoptosis was associated with downregulation of Bcl-2 by gefitinib in MDA-MB-231 cells. These results suggest an additive interaction between the EGFR-TKI gefitinib and the antioestrogen fulvestrant in ER-positive breast cancer cells.
Synthesis of the First (1-3:6,7-η-Cyclodecadienyl)ruthenium Complex by the Intramolecular Reaction of an Alkene and a Vinylcyclopropane (2001)

Ein koordinativ ungesättigter Ruthenium(II)-Komplex reagiert mit einem (Alkenylvinyl)cyclopropan zum ersten Cyclodecadienyl-Ruthenium-Komplex (siehe Schema; nicht spezifizierte Koordinationsstellen am Rutheniumzentrum können durch das Solvens (Aceton) oder Acetonitril besetzt sein). Diese beispiellose, mechanistisch interessante Reaktion macht auf präparative Anwendungen neugierig.
Connecting for Care: a protocol for a mixed-method social network analysis to advance knowledge translation in the field of child development and rehabilitation (2022)

This study will integrate network and KT theory in mapping the structure of the CD&R KT network, enhance our understanding of conventional and network-focused KT barriers and facilitators, and provide recommendations to strengthen KT networks. Recommendations can be applied and tested within the field of CD&R to improve KT, with the aim of ensuring children achieve the best health outcomes possible through timely access to effective healthcare.
The Lucent Technologies Softswitch-Realizing the promise of convergence (2002)

The Lucent Technologies Softswitch was created as a result of Project Saras, which was initiated by two Bell Labs researchers. The purpose of Project Saras was to develop a software system that solves several major problems that providers of telephony services now face. Today's public switched communications infrastructure consists of a variety of different networks, technologies and systems, most of which are still based on the wireline circuit-switched structure. The technology, however, is evolving to packet-based networks, and service providers need the ability to interconnect their customers with these flexible and cost-effective networks without losing the reliability, convenience, and functionality of the public switched telephone network. The Lucent Softswitch, formerly known as the PacketStar† IP Services Platform, resulted from a focus on these needs. This Softswitch was initially marketed as a signaling-interoperability and services-creation platform under the umbrella brand name PacketStar for Lucent data networking products. It was renamed in light of the recognition that it represented an emerging concept in the industry called a “softswitch,” referring to a software-based distributed switching-and-control platform. This paper provides a high-level description of the Lucent Softswitch and its application to building next-generation converged networks.
Model Predictive Control of Vehicles on Urban Roads for Improved Fuel Economy (2012)

Energy consumption of a vehicle is greatly influenced by its driving behavior in highly interacting urban traffic. Strategies for fuel efficient driving have been studied and experimented with in various conceptual frameworks. This paper presents a novel control system to drive a vehicle efficiently on roads containing varying traffic and signals at intersections for improved fuel economy. The system measures the relevant information of the current road and traffic, predicts the future states of the preceding vehicle, and computes the optimal vehicle control input using model predictive control (MPC). A typical control objective is chosen to maximize fuel economy by regulating a safe head-distance or cruising at the optimal velocity under bounded driving torque condition. The proposed vehicle control system is evaluated in urban traffic containing thousands of diverse vehicles using the microscopic traffic simulator AIMSUN. Simulation results show that the vehicles controlled by the proposed MPC method significantly improve their fuel economy.
Template Effect of Crystalline Poly(vinyl alcohol) for Selective Formation of Aragonite and Vaterite CaCO3 Thin Films (2003)

Aragonite thin films of calcium carbonate are selectively formed on crystalline poly(vinyl alcohol) matrices in the presence of poly(acrylic acid) in CaCO3 solution. For thin film formation, this is the first example in which aragonite is formed selectively by cooperation of only synthetic organic macromolecules. In contrast, the addition of poly(glutamic acid) results in the formation of vaterite thin films on the crystalline poly(vinyl alcohol) matrices. These results show that crystalline poly(vinyl alcohol) matrices can be used to select the polymorph from aragonite and vaterite by changing the soluble additive.
A single-photon on demand source with decoupled single and multiphoton probabilities: initial results (2003)

We present an analysis of a multiplexed downconversion system designed to pro-duce a single-photon on-demand source, by a multiple delay line trigger, yielding a single-photon certification of the produced photons. We discuss theoretically a simple implementation of the system together with initial experimental results. The advent of photon-based quantum cryptography, communication and computation schemes1–4 is increasing the need for light sources that pro-duce individual photons; as unwanted additional photons can render quantum cryptographic links insecure and degrade quantum-computation efficiencies.5 More specifically, it would be useful to have these photons created in response to an external trigger, or even to have them arrive repetitively at a fixed, but selectable rate. As currently implemented, single-photon sources cannot be made to produce single photons with high probability, while simultane-ously suppressing the probability of yielding two or more photons. Because of this fact, single photon sources cannot really produce single photons on demand. We have previously described a multiplexed parametric downcon-
Sports Injuries in High School Athletes: A Review of Injury-Risk and Injury-Prevention Research (2006)

The risk factors for injury in several specific sports such as soccer, American football, and basketball have been documented. Other sports are less well represented in the current literature. The risk factors for injuries to the ankle, head, and knee have been identified, to a limited degree. Upper-extremity injury risk factors are less well known. There is a need for high-quality prospective studies to further identify injury risk factors and injury-prevention strategies for high school athletes.
Polymerase chain reaction (PCR) for detection of EcoRI polymorphism at the THRB gene (1991)

Polymerase chain reaction (PCR) for detection of EcoRI polymorphism at the THRB gene P.S. Ganly, P.S. Ganly Medical Research Council Clinical Oncology and Radiotherapeutics Unit, Medical Research Council CentreHills Road, Cambridge, CB2 2QH, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar P.H. Rabbitts P.H. Rabbitts Medical Research Council Clinical Oncology and Radiotherapeutics Unit, Medical Research Council CentreHills Road, Cambridge, CB2 2QH, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 13, 11 July 1991, Page 3760, https://doi.org/10.1093/nar/19.13.3760-a Published: 11 July 1991
Steric inhibition of gaseous ionic acetylation (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteric inhibition of gaseous ionic acetylationSteven A. Benezra and Maurice M. BurseyCite this: J. Am. Chem. Soc. 1972, 94, 3, 1024Publication Date (Print):February 1, 1972Publication History Published online1 May 2002Published inissue 1 February 1972https://pubs.acs.org/doi/10.1021/ja00758a067https://doi.org/10.1021/ja00758a067research-articleACS PublicationsRequest reuse permissionsArticle Views33Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Non-contact continuous-wave diffuse optical tomographic system to capture vascular dynamics in the foot (2015)

Dynamic optical tomographic imaging has shown promise in diagnosing and monitoring peripheral arterial disease (PAD), which affects 8 to 12 million in the United States. PAD is the narrowing of the arteries that supply blood to the lower extremities. Prolonged reduced blood flow to the foot leads to ulcers and gangrene, which makes placement of optical fibers for contact-based optical tomography systems difficult and cumbersome. Since many diabetic PAD patients have foot wounds, a non-contact interface is highly desirable. We present a novel non-contact dynamic continuous-wave optical tomographic imaging system that images the vasculature in the foot for evaluating PAD. The system images at up to 1Hz by delivering 2 wavelengths of light to the top of the foot at up to 20 source positions through collimated source fibers. Transmitted light is collected with an electron multiplying charge couple device (EMCCD) camera. We demonstrate that the system can resolve absorbers at various locations in a phantom study and show the system’s first clinical 3D images of total hemoglobin changes in the foot during venous occlusion at the thigh. Our initial results indicate that this system is effective in capturing the vascular dynamics within the foot and can be used to diagnose and monitor treatment of PAD in diabetic patients.
Cockroach Allergen Bla g 2: Structure, Function, and Implications for Allergic Sensitization (2002)

Exposure to German cockroach (Blattella germanica) allergens is associated with the development of chronic respiratory diseases, especially asthma. The mechanism by which allergic patients develop specific immunoglobulin E (IgE) responses to environmental allergens is unknown. However, recent reports provided evidence that enzyme activity, especially proteolytic activity, was a major contributor to allergenicity. Bla g 2 is one of the most potent cockroach allergens (prevalence of IgE responses of 60 to 80%) and shows homology to the aspartic proteinase family of enzymes. We investigated whether the allergenicity of Bla g 2 was linked to its putative enzymatic function. A molecular model of Bla g 2, based on the high resolution crystal structures of pepsin and chymosin, showed that the overall three-dimensional structure of Bla g 2 was similar to that of aspartic proteinases with a well-defined binding pocket. However, critical amino acid substitutions in the catalytic triads and in the "flap" region of the molecule suggested that Bla g 2 was inactive and homologous to mammalian pregnancy-associated glycoproteins. This was confirmed experimentally by enzyme assay. The results show dissociation between enzymatic activity and allergenicity for Bla g 2 and suggest that other genetic and environmental factors are important determinants of sensitization.
Heterogeneous sonocatalysis with nickel powder (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHeterogeneous sonocatalysis with nickel powderKenneth S. Suslick and Dominick J. CasadonteCite this: J. Am. Chem. Soc. 1987, 109, 11, 3459–3461Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/ja00245a047https://doi.org/10.1021/ja00245a047research-articleACS PublicationsRequest reuse permissionsArticle Views632Altmetric-Citations129LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Structure of a Protected C3‐C10 Subunit of Erythromycin and Its C8 Epimer. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
LAUNCHPADS: A System for Processing Ad Hoc Data. (2006)

An Introduction to PADS. Ideally, any data we ever encounter will be presented to us in standardized formats, such as XML. Why? Because for formats like XML, there are a whole host of software libraries, query engines, visualization tools and even programming languages specially designed to help users process
Celular de Guerrilha: usos subversivos da tecnologia móvel no Brasil (Monográfico). (2015)

Assim que uma tecnologia e implementada em uma cultura, e possivel observar usos sociais imprevistos pelos seus inventores ou produtores. As pessoas criam estrategias para aproveitar o novo recurso. Usando teorias de interacao social e abordagem etnografica em situacoes cotidianas de uso do telefone celular no Brasil, observamos como as pessoas usam esta tecnologia para comunicacao interpessoal. Este artigo aborda tres usos subversivos da telefonia movel: i) estrategias de codificacao; ii) gerenciamento de cartoes SIM; e iii) os usos criminosos de telefones celulares.

As soon as a technology is implemented in a culture, it is possible to observe social uses that were not intended by the inventors or producers of that technology. People create strategies to take advantage of the new resource. Using social interaction theories and an ethnographic approach in the natural setting of cell phone use in Brazil, we observed how people use the mobile phone technology for interpersonal communication. This paper addresses three subversive uses of mobile technology, namely, i) strategies of mobile phone coding; ii) SIM card management; and iii) criminal uses of mobile phones.

Tan pronto una tecnologia se implementa en una cultura, es posible observar usos sociales imprevistos por sus inventores o productores. Las personas crean estrategias para aprovechar un nuevo recurso disponible. A traves de teorias sobre la interaccion social y un enfoque etnografico en el entorno natural de uso de telefonos moviles en Brasil, se observo como la gente usa la telefonia movil para su comunicacion interpersonal. Este articulo aborda tres usos subversivos de la telefonia movil: i) estrategias de codificacion; ii) gestion de la tarjeta SIM; y iii) usos criminales de telefonos moviles.
Comparison of a Novel Liquid (Adcon-P®) and a Sodium Hyaluronate and Carboxymethylcellulose Membrane (Seprafilm™) in Postsurgical Adhesion Formation in a Murine Model (2003)

This study suggests that both Adcon-P and Seprafilm trade mark decrease the incidence of postoperative adhesions and the difficulty of adhesiolysis in the murine cecal abrasion model. However, Adcon-P appeared to be superior to Seprafilm. This agent is an attractive device that requires additional studies.
Superlubricious surface mimicking articular cartilage by grafting poly(2‐methacryloyloxyethyl phosphorylcholine) on orthopaedic metal bearings (2008)

Aseptic loosening of the artificial hip joint with osteolysis due to the wear particles from polyethylene cup has remained as a serious issue. To reduce this wear and develop a novel artificial hip joint system, we produced a superlubricious metal-bearing material: for this, we grafted a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer onto the surface of a cobalt-chromium-molybdenum (Co-Cr-Mo) alloy. For ensuring long-term benefit retention of poly(MPC) on the Co-Cr-Mo alloy for application as a novel artificial hip joint system, several issues must be considered: strong bonding between poly(MPC) and Co-Cr-Mo surface, high mobility of free end groups of the poly(MPC) layer, and high density of the introduced poly(MPC). Considering these issues, we introduced a 3-methacryloxypropyl trimethoxysilane (MPSi) intermediate layer and a photoinduced graft polymerization technique to create a strong covalent bond between the Co-Cr-Mo substrate and the poly(MPC) chain via the MPSi layer. The thickness and density of the poly(MPC) layer on the surface increased with the MPC concentration and photoirradiation time. The grafted poly(MPC) layer successfully provided super-lubricity to the Co-Cr-Mo surface. The poly(MPC)-grafted crosslinked polyethylene/poly(MPC)-grafted Co-Cr-Mo or cartilage/poly(MPC)-grafted Co-Cr-Mo bearing interface mimicking natural joints showed an extremely low friction coefficient of 0.01, which is as low as that of natural cartilage interface. A superlubricious metal-bearing surface would enable the development of a novel biocompatible artificial hip joint system-artificial femoral head for partial hemiarthroplasty and metal-on-polymer/metal type for total hip arthroplasty.
Clinical applications of pharmacogenetics in HIV (2008)

Given on behalf of Dr. Elizabeth Phillips, Dr. Mallal presents pharmacogenetics and pharmacogenomics in clinical practice. Polymorphisms in both hosts and pathogens constitute a large challenge in therapy. Pathogenic adaptability, as seen in HIV, will shape the response to particular drug interventions. Similarly, the host genetic makeup will also affect the response to treatment. Drugs therefore help us elucidate these polymorphic backgrounds.&#13;\n&#13;\nPharmacogenetics refers to a clinical entity (phenotype) that is further characterized by genetics (genotype). Conversely, pharmacogenomics attempts to identify the genotype in order to predict the risk of developing a particular phenotype.&#13;\n&#13;\nPharmacogenetic and pharmacogenomic approaches in choosing an optimal antiretroviral regimen are exemplified in abacavir hypersensitivity reactions. Clinical diagnosis of abacavir hypersensitivity has been shown to yield false positives (CNA3005, CNA30024). This over diagnosis subsequently leads to prompt discontinuation of abacavir which incurs significant healthcare costs. A study by Dr. Phillips and colleagues (2005) demonstrated that disrupting treatment too early resulted in increased consultations with emergency physicians and/or specialists with higher costs for services. Furthermore, it took longer for these patients to achieve undetectable viral loads.&#13;\n&#13;\nStudies show that abacavir hypersensitivity can be more accurately diagnosed with the patch test. Dr. Mallal reiterates the differences between pharmacogenetics and pharmacogenomics by pointing out that patch testing should be employed in abacavir sensitized individuals, therefore serving as a diagnostic test and not a predictive test.
An adaptive interactive agent for route advice (1999)

Current route advice systems present a single route to the driver based on static evaluation criteria, with little or no recourse if the driver finds this solution unsatisfactory.In this paper, we propose a more flexible approach and its implementation in the Adaptive Route Advisor.Our system behaves more like a human travel agent, using driver preferences, when known, and working with him or her to find a satisfactory route.The route advisor predicts what route a driver will prefer based on a model of driver preferences, and, if the predicted route is unsatisfactory, it generates additional routes based on interaction with the driver.The route that the driver eventually selects serves as feedback to improve the preference model.We present a pilot study on using these route selections to construct a personalized model.As the preference model becomes more accurate, the need for interaction decreases and the driver receives better route advice.
Characterization of freshly isolated bone marrow mesenchymal stromal cells from healthy donors and patients with multiple myeloma: transcriptional modulation of the microenvironment (2020)

Characterization of freshly isolated bone marrow mesenchymal stromal cells from healthy donors and
From urban underground space (UUS) to sustainable underground urbanism (SUU): Shifting the focus in urban underground scholarship (2021)

This viewpoint argues that for sustainable urban development the relationship between the city and the ground beneath it needs increased attention. The underground volume might provide additional urban space, but it cannot be treated in the same way as above-ground space. Cross-disciplinary research and professional collaboration are needed to better understand (a) the variety of processes at play, and (b) the role of geotechnical engineers and geoscientists in working towards sustainable underground urbanism.