gebhart/patrepeval huggingface dataset:
Humoral response to different vaccination schemes against classical swine fever (CSF) successively applied during an outbreak of the disease (2009)

Vaccination against classical swine fever (CSF) is an essential measure for its control in endemic areas, and the Chinese Strain has been used with success in already disease free countries. Nevertheless the complexity of the factors interacting on the epidemiology and control of CSF, when the expected success is not reached with the vaccination of premises, doubts always fall on the vaccine used and the vaccination scheme applied In consecuences, many changes in vaccination scheme by the breeders are frecuently observed whitout positive influence in CSF control. To clarify the CSF recurrence in a herd vaccinated by a different scheme as the one recommended in the national control program, serological samples were taken to different animal groups in three moments. Sample I, to evaluate the response to the vaccination scheme decided by producers (litters on 5 and 40 days); and samples II and III, to know its behaviour after the implementation of the scheme recommended by official veterinary service (litters at weaning, at 33 days). The presence of titres =1:50 in all litters at 3 days of age (Sample I), indicated that primo-vaccination at 5 days is not correct. The absence of protective titres on 22% of the animals (9/41), belonging to the groups with clinical cases of the disease, at only 23-30 days from the second doses, confirmed that the double vaccination scheme at 5 and 40 days was not correct. Although at 33 days of age a risk of vaccinating in the presence of high titres of passive antibodies (=1:50) in 65% of the pigs was present (Sampling II), it was verified that at 37 post-vaccination days all pigs showed high neutralizing antibodies titres (Sampling III). This result, together with the clinical behaviour and humoral response of pigs on pre- fattening demonstrated that primo-vaccination at 33 days was adequate and contributed to the control of clinical manifestation of the diseases in the herd.
The Linux router (2002)

Sure a Linux router is cheaper than a Cisco router, but how does it stack up performance-wise?
Supplementary Table S5 from Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression (2023)

&lt;p&gt;Supplementary Table S5: Proteomic analysis of the IDH2-perturbed cells&lt;/p&gt;
The search for gravitational wave bursts in data from the second LIGO science run (2005)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2005.
Flutter/Limit Cycle Oscillation Analysis and Experiment for Wing-Store Model (2006)

A delta wing experimental model with an external store has been designed and tested in the Duke University wind tunnel. The wing structure is modeled theoretically by using von Karman plate theory that allows for geometric strain-displacement nonlinearities in the plate wing structure. A component modal analysis is used to derive the full structural equations of motion for the wing/store combination system. A three-dimensional time domain vortex lattice aerodynamic model including a reduced-order model aerodynamic technique and a slender-body aerodynamic theory for the store are also used to investigate the nonlinear aeroelastic system. The effects of the store pitch stiffness (attachment stiffness), the span location of store, and the store aerodynamics on the critical flutter velocity and limit cycle oscillations (LCO) are discussed. The correlations between the theory and experiment are good for both the critical flutter velocity and frequency but not good for the LCO amplitude, especially when the store is located near the wing tip. The theoretical structural model needs to be improved to determine LCO response, and improved results are shown in the companion paper as obtained with a higher-order structural model.
Phospholipase D modified with a polyethylene glycol derivative. (1991)

Phospholipase D from Streptomyces sp. AA586, PLDP, was modified with methoxypolyethylene glycol succinimidylsuccinate (ss-PEG), an active derivative of polyethylene glycol. By titration with trinitrobenzene sulfonate (TNBS), approximately 70% of the free amino groups in the enzyme protein were shown to be modified by treatment with ss-PEG. By this modification, the molecular weight of the enzyme was increased, judging from the results of sodium dodecyl sulfate-polyacrylamide gel electrophoresis, gel filtration with Toyopearl HW-55F and TNBS titration. Due to loss of cationic charges, the enzyme protein became eluted faster in high performance liquid chromatography with CM-Toyopearl. By modification with ss-PEG, the enzyme became fairly thermostable, while pH-stability and optimal pH were not influenced. The value of Km for phosphatidylcholine of the hydrolytic reaction increased 2-fold, whereas that of the transphosphatidyl reaction was not significantly altered.
Chlorides in Handcuffs (2011)

While many examples of simple ­interlocked systems have been synthesized, the formation of more complex interlocked structures, such as handcuff catenanes, remains a challenge. The authors synthesized a member of this class of compounds (3) using chloride ions in a template macrocyclization reaction.
The Atypical Hysteresis of [Fe(C6F5Tp)2]: Overlay of Spin‐Crossovers and Symmetry‐Breaking Phase Transition (2021)

Abstract The [Fe II (C 6 F 5 Tp) 2 ] spin‐crossover complex is an atypical molecular switch, which can be converted upon annealing between two archetypal spin‐crossover behaviours: from an extremely gradual spin‐crossover to a broad hysteretic spin‐transition (of ca. 65 K). The hysteresis shows an uncommon “rounded shape” that is reproducible upon cycling temperature. In depth structural studies reveal a first crystal phase transition, which occurs upon melting and recrystallizing at high temperature. This first irreversible transition is associated with a radical change in the crystal packing. More importantly, the “rounded and broad” hysteretic transition is shown to occur in a non‐cooperative SCO system and is associated with the occurrence of a symmetry‐breaking phase transition that appears when roughly ca. 50 % of the SCO complexes are switched.
Recombinant porcine factor VIII corrects thrombin generation in vitro in plasma from patients with congenital hemophilia A and inhibitors (2022)

Recombinant porcine factor VIII demonstrated a dose-dependent correction of thrombin generation and clot formation in vitro, dependent on the anti-porcine FVIII inhibitor titer. Procoagulant responses to rpFVIII occurred in plasma containing FVIII inhibitors.
Temporal phase shift measurement in χ/sup (2)/ cascading process using a sonogram technique (2002)

Summary form only given. Optical properties of materials can be retrieved through a complete characterization in intensity and phase of a laser pulse after propagation into the sample. Among all the available techniques, the frequency domain phase measurement (FDPM) technique does offer a direct reconstruction of the pulse without any iterative algorithm and this approach has been applied to analyze the behaviour of the phase for /spl chi//sup (2)/ cascading processes. The cascading effect has been proposed to compensate the self-phase modulation in nonlinear propagation as an adjustable effective third-order nonlinearity. This can be easily seen in the time domain and the corresponding sonogram results have been obtained for a BBO crystal.
p38 MAPK Inhibition Improves Heart Function in Pressure-Loaded Right Ventricular Hypertrophy (2017)

Although p38 mitogen-activated protein kinase (MAPK) is known to have a role in ischemic heart disease and many other diseases, its contribution to the pathobiology of right ventricular (RV) hypertrophy and failure is unclear. Therefore, we sought to investigate the role of p38 MAPK in the pathophysiology of pressure overload-induced RV hypertrophy and failure. The effects of the p38 MAPK inhibitor PH797804 were investigated in mice with RV hypertrophy/failure caused by exposure to hypoxia or pulmonary artery banding. In addition, the effects of p38 MAPK inhibition or depletion (by small interfering RNA) were studied in isolated mouse RV fibroblasts. Echocardiography, invasive hemodynamic measurements, immunohistochemistry, collagen assays, immunofluorescence staining, and Western blotting were performed. Expression of phosphorylated p38 MAPK was markedly increased in mouse and human hypertrophied/failed RVs. In mice, PH797804 improved RV function and inhibited cardiac fibrosis compared with placebo. In isolated RV fibroblasts, p38 MAPK inhibition reduced transforming growth factor (TGF)-β-induced collagen production as well as stress fiber formation. Moreover, p38 MAPK inhibition/depletion suppressed TGF-β-induced SMAD2/3 phosphorylation and myocardin-related transcription factor A (MRTF-A) nuclear translocation, and prevented TGF-β-induced cardiac fibroblast transdifferentiation. Moreover, p38 MAPK inhibition in mice exposed to pulmonary artery banding led to diminished nuclear levels of MRTF-A and phosphorylated SMAD3 in RV fibroblasts. Together, our data indicate that p38 MAPK inhibition significantly improves RV function and inhibits RV fibrosis. Inhibition of p38 MAPK in RV cardiac fibroblasts, resulting in coordinated attenuation of MRTF-A cytoplasmic-nuclear translocation and SMAD3 deactivation, indicates that p38 MAPK signaling contributes to distinct disease-causing mechanisms.
Thermal and heat-flow aspects of actuators for hard disk drives (2002)

Thermal, heat-flow, and airflow characteristics of actuators for hard disk drives (HDDs) were investigated. The major mode of actuator cooling comes from conductive heat transfer, which is caused by the close proximity of components in the actuator. The temperature data was used to deduce the thermal distortion in the actuator. Tracking errors predicted by the actuator model agreed reasonably well with those measured in a test HDD operated at a similar thermal condition. Because of the complicated construction and structure of the hard disk drive's actuator, it can interact with the thermal field causing distortions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Design of a 35-mm photographic objective using axial GRIN materials (1993)

A photographic objective employing axial gradient-index (GRIN) elements is described and compared with a conventional double Gauss lens. Comparable imaging performance and increased relative illumination at the edge of field are realized in the GRIN design even though it has fewer optical elements.
Fairness via Source Throttling (2012)

Cores in chip-multiprocessors (CMPs) share multiple memory subsystem resources. If resource sharing is unfair, some applications can be delayed significantly while others are unfairly prioritized. Previous research proposed separate fairness mechanisms for each resource. Such resource-based fairness mechanisms implemented independently in each resource can make contradictory decisions, leading to low fairness and performance loss. Therefore, a coordinated mechanism that provides fairness in the entire shared memory system is desirable. This article proposes a new approach that provides fairness in the entire shared memory system, thereby eliminating the need for and complexity of developing fairness mechanisms for each resource. Our technique, Fairness via Source Throttling (FST), estimates unfairness in the entire memory system . If unfairness is above a system-software-set threshold, FST throttles down cores causing unfairness by limiting the number of requests they create and the frequency at which they do. As such, our source-based fairness control ensures fairness decisions are made in tandem in the entire memory system. FST enforces thread priorities/weights, and enables system-software to enforce different fairness objectives in the memory system. Our evaluations show that FST provides the best system fairness and performance compared to three systems with state-of-the-art fairness mechanisms implemented in both shared caches and memory controllers.
Improved therapy for medulloblastoma: targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy (2018)

Aberrant activation and interactions of hedgehog (HH) and PI3K/AKT/mTOR signaling pathways are frequently associated with high-risk medulloblastoma (MB). Thus, combined targeting of the HH and PI3K/AKT/mTOR pathways could be a viable therapeutic strategy to treat high-risk patients. Therefore, we investigated the anti-MB efficacies of combined HH inhibitor Vismodegib and PI3K-mTOR dual-inhibitor BEZ235 together or combined individually with cisplatin against high-risk MB. Using non-MYC- and MYC-amplified cell lines, and a xenograft mouse model, the <i>in vitro</i> and <i>in vivo</i> efficacies of these therapies on cell growth/survival and associated molecular mechanism(s) were investigated. Results showed that combined treatment of Vismodegib and BEZ235 together, or with cisplatin, significantly decreased MB cell growth/survival in a dose-dependent-fashion. Corresponding changes in the expression of targeted molecules following therapy were observed. Results demonstrated that inhibitors not only suppressed MB cell growth/survival when combined, but also significantly enhanced cisplatin-mediated cytotoxicity. Of these combinations, BEZ235 exhibited a significantly greater efficacy in enhancing cisplatin-mediated MB cytotoxicity. Results also demonstrated that the MYC-amplified MB lines showed a higher sensitivity to combined therapies compared to non-MYC-amplified cell lines. Therefore, we tested the efficacy of combined approaches against MYC-amplified MB growing in NSG mice. <i>In vivo</i> results showed that combination of Vismodegib and BEZ235 or their combination with cisplatin, significantly delayed MB tumor growth and increased survival of xenografted mice by targeting HH and mTOR pathways. Thus, our studies lay a foundation for translating these combined therapeutic strategies to the clinical setting to determine their efficacies in high-risk MB patients.
Electromagnetic Buckled Beam Oscillator for Enhanced Vibration Energy Harvesting (2012)

In this work, a nonlinear vibration energy harvester consisting of a buckled beam and an electromagnetic transducer is proposed. An advantage of this device is that there is no need of permanent magnets to create the bistable potential. Theoretical modeling and experimental investigations on a prototype are presented. The prototype demonstrates a peak power of 2.96 mW at resonance of 52 Hz under 0.32 g of acceleration in the unbuckled configuration, while under bistable regime, it shows a gain up to 115% of power. Besides, both systems show a large bandwidth response compared to resonant cantilever devices.
Solid lipid nanaoparticles as new drug delivery system (2011)

The main challenge in cancer chemotherapy is toxic side-effects induced by chemotherapeutic drugs. Thus, alternative methods of drug administration like appropriate drug carrier system is needed to overcome this problem. The main objective of new drug delivery systems is to improve the anti-tumor efficacy of drug and reduce their toxic effects on normal tissues. Recently Solid Lipid Nanoparticles (SLN) as colloidal particulate drug delivery system have received much attention from drug development researchers. The use of solid lipid nanoparticle opens up new perspectives for the formulation of poorly soluble drugs. The SLN is a very complex system with some advantages and disadvantages over other colloidal carrier systems. Tamoxifen, an antiestrogen molecule and strong hydrophobic drug is used as a chemotherapy drug against breast cancers. When tamoxifen encapsulated within solid lipid nanoparticles, it is like free TAM display antitumoral activity against human breast cancer cells. The biological availability of drug is not affected when incorporated into SLN. Therefore SLN could be applied as a drug delivery system for cancer treatments.

	Key words: Drug delivery systems, solid lipid nanoparticles.
Identified key genes related to carotid atheroma plaque from gene expression chip (2016)

As one of the leading reason in morbidity and death in the world, atherosclerosis is usually associated with vessel stenosis, ulceration, and inflammatory cell infiltration. However, the formation mechanism of atheroma plaque is unknown. In this research, we have used bioinformatics tools to identify 118 differential expression genes from a GEO dataset. Besides, we also revealed KYNU as a crucial gene in atheroma plaque development.
Transition‐Metal Complexes Featuring Z‐Type Ligands: Agreement or Discrepancy between Geometry and dn Configuration? (2007)

Liganden sind Gold wert: Die Koordination von ambiphilen Diphosphanylboran-Liganden an AuCl ergibt ungewöhnliche quadratisch-planare Gold(I)-Komplexe. NBO-Analysen und 197Au-Mößbauer-Spektroskopie geben Aufschluss über die Eigenschaften der Gold→Boran-Wechselwirkung. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2007/z703518_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Estimating allergenicity of latex gloves using Hev b 1 and hevamine. (2010)

Our results suggest that the measurement of residual extractable total proteins is not sufficient to assess the allergenicity of latex gloves and that Hev b 1 and hevamine may be used as indicator allergens in areas where they are major latex allergens, such as Taiwan.
Influence of Mg2+-ions on the properties of rat heart mitochondria in dependence on the preparation. (1978)

1. The preparation of rat heart mitochondria with Potter-Elvehjem homogenizer results in mitochondria showing stimualtion of respiration induced by Mg2+. This stimualtion is neither caused by adherent hexokinase nor by energy-dependent magnesium accumulation (Mg2+ content in the presence of 10 mM glutamate: 22 nmoles/mg protein; in the presence of glutamate plus antimycin A 21 nmoles/mg protein). 2. The effect of added magnesium is excluded by addition of carboxyatractyloside. This demonstrates the activity of an ATPase outside of the mitochondrial inner membrane. 3. A simple and rapid method for the preparation of Mg2+-insensitive rat heart mitochondria is presented. The minced heart is pressed through a normal syringe and then treated with trypsin. 4. A comparison of mitochondria of both preparations shows that there is no difference in magnesium content and no energy-dependent magnesium influx.
Optimisation of Bile Production during Normothermic Preservation of Porcine Livers (2002)

Machine perfusion of livers may provide a mechanism for extended preservation of marginal donor organs before transplantation, as well as a method for viability assessment. It has proved possible in a series of experimental porcine liver perfusions to maintain liver viability for up to 72 h. However, a reduction in bile production with associated histological evidence of cholestasis was seen after 10 h of perfusion, damaging the biliary canaliculi during the preservation period and leaving these organs in an unacceptable condition for transplantation. It was proposed that reduction in bile production was the result of a relentless depletion of available bile salts, gut recirculation not being possible and de-novo synthesis being unable to keep up with loss. This was proved by measuring porcine native bile acids within serial perfusate and bile samples using gas chromatography mass spectrophotometry. It was shown that all three native pig bile acids were decreased to 30% of their original value by 20 h of unsupplemented perfusion. An infusion of taurocholate managed to maintain bile production at physiological levels throughout the 20-h period (8 mL/h +/- 0.75). It was successfully incorporated by the porcine livers into bile. We propose to use this circuit as a novel means of preserving donor livers for transplantation in which the organ is maintained at normal body temperature and perfused with blood. This will reduce ischaemia reperfusion injury and may enable prolonged preservation. The modification described ensures optimal bile production over the entire perfusion period, preventing inspissation and subsequent damage to the canaliculus.
Case study of active array feed compensation with sidelobe control for reflector surface distortion (2003)

The feasibility of electromagnetically compensating for reflector surface distortions has been investigated. The performance characteristics (gain, sidelobe level, null location, beamwidth, etc.) of large communication antenna systems degrade as the reflector surface distorts mainly due to thermal effects from a varying solar flux. The techniques described can be used to maintain the design performance characteristics independently of thermal effects on the reflector surface. It is assumed that the surface characteristics (x, y, z, its first and second derivatives) under distortion conditions are known. Surface error compensating techniques with an array feed are examined using an offset parabolic reflector geometry and a sinusoidal distortion profile.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Comparison of Six Different Regimens for the Control of Atrophic Rhinitis in Swine (1990)

Effectiveness of six different programs of atrophic rhinitis (AR) control was evaluated under field conditions. Efficacy of treatments was recognized on the basis of--comparative evaluation of the average daily gain (ADG), morphometric examination of turbinate bones and computer conchal morphometry (TPR). Usefulness of the evaluated regimes differed significantly. TPR appeared to be the most objective method for AR evaluation. Correlation between severity of turbinate atrophy and ADG was only partial.