gebhart/patrepeval huggingface dataset:
SuperB: a Linear High-Luminosity B Factory (2006)

This paper is based on the outcome of the activity that has taken place during the recent workshop on ''SuperB in Italy'' held in Frascati on November 11-12, 2005. The workshop was opened by a theoretical introduction of Marco Ciuchini and was structured in two working groups. One focused on the machine and the other on the detector and experimental issues.. The present status on CP is mainly based on the results achieved by BABAR and Belle. Establishment of the indirect CP violation in B sector in 2001 and of the direct CP violation in 2004 thanks to the success of PEP-II and KEKB e{sup +}e{sup -} asymmetric B Factories operating at the center of mass energy corresponding to the mass of the {Upsilon}(4S ). With the two B Factories taking data, the Unitarity Triangle is now beginning to be over constrained by improving the measurements of the sides and now also of the angles {alpha}, and {gamma}. We are also in presence of the very intriguing results about the measurements of sin2{beta} in the time dependent analysis of decay channels via penguin loops, where b {yields} s{bar s}s and b {yields} s{bar d}d. {tau} physics, in particular LFV search, as well as charm and ISR physics are important parts of the scientific program of a SuperB Factory. The physics case together with possible scenarios for the high luminosity SuperB Factory based on the concepts of the Linear Collider and the related experimental issues are discussed.
Cytomegalovirus Infection (2009)

This chapter contains sections titled: Introduction Molecular and clinical biology Epidemiology and etiology of CMV-associated disease Immune response to CMV infection Clinical description of CMV-associated disease Prevention of CMV infection after HCT Conclusion References
Concept of molecular design towards additive technology for advanced lubricants (2007)

Abstract A simple model to develop novel friction modifiers and anti‐wear agents for synthetic oils was studied. Our attention was focused on the construction of additive molecules to meet the requirement for synthetic oils, which possess a different polarity and solvency from mineral oils. The relation between the molecular structure of additives and their tribological properties were elucidated prior to the preparation of the substance and estimation of its tribological properties. Computer‐assisted chemistry was partly applied to predict the properties of the designed molecules. The adsorptive activity of the conventional fatty acids is insufficient to reduce friction when they were dissolved in polar synthetic oils such as polyethers. Introduction of another carboxyl group into the fatty acid, especially at the carbon atom next to the original carboxyl group, makes the molecule polar; resulting in friction modifiers for polyethers. Conversion of the carboxyl groups into trimethylsilyl esters provides soluble friction modifiers for poly(dimethylsilicone)‐type synthetic oils. A unique lubrication mechanism based on in situ regeneration of the original molecule was proposed for synthetic oils with poor solvency. Importance of adsorptive activity of additive molecule was also pointed out in phosphate‐type anti‐wear additives for polar synthetic oils. We found that both the polarity of additives and that of base oils have to be taken into account in lubricant design. Too much adsorption activity of the molecule caused corrosive wear. Hydrolytic stable compounds reduces corrosive wear to a considerable extent. Introduction of a hydroxyl group into the alkyl moiety of the phosphate ester provides polar molecule with low acidity. The additives reduce wear in synthetic esters even at low concentrations of phosphorus. The lubrication mechanism was also discussed; the novel additives provide a thick boundary film composed of iron phosphate on rubbing surfaces. Moreover, an acceleration of the kinetics of the film formation by the hydroxyl group was observed. Copyright © 2007 John Wiley &amp; Sons, Ltd.
Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system (1983)

Trycyclic antidepressants are often effective in the management of neuropathic pains. To elucidate the mechanism of tricyclic-induced analgesia, amitriptyline and other drugs were injected into lightly anesthetized rats either systemically or via lumbar intrathecal cannulas. Analgesia was assessed by measuring the latency of the tail flick reflex. Using this model, intrathecal amitriptyline (30 micrograms) significantly enhanced the analgesic effect of an intraperitoneal dose of morphine (0.5 mg/kg) that by itself produced no measurable effect. Given systemically, amitriptyline (30 or 100 micrograms intraperitoneally) was ineffective. Cocaine (30 micrograms) also potentiated morphine analgesia, but iprindole, a tricyclic antidepressant with a very weak inhibitory effect on monoamine uptake, was ineffective. This enhancement of analgesia by intrathecal amitriptyline was prevented by pretreating the rats with p-chlorophenylalanine (300 mg/kg). These results are consistent with the hypothesis that amitriptyline produces analgesia by blocking serotonin uptake and therefore enhancing the action of serotonin at the spinal terminals of an opioid-mediated intrinsic analgesia system.
Elevated admission N-terminal pro-brain natriuretic peptide level predicts the development of atrial fibrillation in general surgical intensive care unit patients (2017)

Elevated NT-proBNP at ICU admission in general surgical and trauma patients is predictive of AF development in the first 3 ICU days. Addition of NT-proBNP measurement to known risk factors can improve predictive power and identify patients who might potentially benefit from evidence-based prophylactic treatment for AF.
Software for Simulating Air Traffic (2006)

Future Air Traffic Management Concepts Evaluation Tool (FACET) is a system of software for performing computational simulations for evaluating advanced concepts of advanced air-traffic management. FACET includes a program that generates a graphical user interface plus programs and databases that implement computational models of weather, airspace, airports, navigation aids, aircraft performance, and aircraft trajectories. Examples of concepts studied by use of FACET include aircraft self-separation for free flight; prediction of air-traffic-controller workload; decision support for direct routing; integration of spacecraft-launch operations into the U.S. national airspace system; and traffic- flow-management using rerouting, metering, and ground delays. Aircraft can be modeled as flying along either flight-plan routes or great-circle routes as they climb, cruise, and descend according to their individual performance models. The FACET software is modular and is written in the Java and C programming languages. The architecture of FACET strikes a balance between flexibility and fidelity; as a consequence, FACET can be used to model systemwide airspace operations over the contiguous U.S., involving as many as 10,000 aircraft, all on a single desktop or laptop computer running any of a variety of operating systems. Two notable applications of FACET include: (1) reroute conformance monitoring algorithms that have been implemented in one of the Federal Aviation Administration s nationally deployed, real-time, operational systems; and (2) the licensing and integration of FACET with the commercially available Flight Explorer, which is an Internet- based, real-time flight-tracking system.
Proton-exchanged periodically segmented waveguides in LiNbO_3 (1994)

We report on the characterization of single-mode and multimode proton-exchanged periodically segmented waveguides in lithium niobate. Variation of effective indices of different modes for different annealing times as a function of duty cycle and period of segmentation is presented. It is shown that the proton-exchanged periodically segmented waveguide can be modeled by an equivalent z-invariant depth-independent graded-index waveguide with a Gaussian index distribution. Although the depth of the equivalent waveguide is independent of duty cycle, the peak refractive-index change increases almost linearly with the duty cycle and saturates at large duty cycles. The results should benefit the design of linear and nonlinear devices that are based on segmented waveguides.
Delay in diagnosis of pulmonary tuberculosis: a survey in the Lazio region, Italy (2022)

&#x0D; OBJECTIVE: To estimate patient and health care delays in the diagnosis of PTB and to evaluate associated factors.&#x0D; METHODS: PTB incident cases ≥18 years diagnosed between September 2010 and September 2011 in the Lazio region; information on symptoms and date of onset, health professionals contacts, diagnostic exams performed, and drugs prescribed before diagnosis were collected through a standardized questionnaire. The total delay (TD) was divided into patient delay (PD: from symptoms onset to first contact with healthcare services) and health system delay (HSD: from first contact to diagnosis).&#x0D; RESULTS: 278 cases were evaluated. Median PD,HSD, and TD, were 31, 15, and 77.5 days, respectively. The median PD, HSD, and TD were significantly lower in foreign born patients (26, 10.5, 63.5, vs. 45, 36, 100 days, respectively). Other factors independently associated with longer delay were: absence of fever and presence of weight loss for PD; prior unspecific treatment, absence of cough, consult with a general practitioner, visit to an outpatient clinic, and a PD &lt;30 days for HSD.&#x0D; CONCLUSIONS: In Italy, the delay in TB diagnosis is similar to that estimated in other European countries. Results indicate that actions aimed to reduce diagnostic delay should be primarily addressed to Italian patients.
A European comparative study of serological methods for the diagnosis of infectious bovine rhinotracheitis (1993)

A comparison is made of serological diagnostic procedures used for infectious bovine rhinotracheitis in the European Community. A panel of 65 sera, including positive, doubtful, negative and diluted samples was dispatched to nine different European laboratories and tested by neutralisation, enzyme-linked immunosorbent assay (ELISA), indirect immunofluorescence and passive haemagglutination, according to the methods used in each laboratory. The results showed good agreement between the various tests for positive and negative sera. However, considerable variability between tests was noted in the "doubtful" category of sera. The highest test sensitivity, as judged by the detection limit for samples serially diluted in negative serum, was found with the blocking ELISAs. A need was identified for international standard reference sera to be made available.
Integration of GIS and educational achievement data for education policy analysis and decision-making (2006)

Effective exploration and analysis of spatially referenced educational achievement data can help educational stakeholders and policy analysts accelerate interpretation of datasets to gain valuable insights. This demonstration will present a system developed in the National Office for Research on Measurement and Evaluation Systems (NORMES) for supporting web-based interactive exploration of state-wide educational data. The statewide statistical summaries are presented in thematic maps generated by Geographic Information System (GIS). Visual analysis of the thematic maps can help educational policy analysts to "see" complex spatial relationships and to detect patterns easily. Linking among GIS maps allows educators to interactively "drill down" through a hierarchy of geopolitical levels and to visualize statistical graphics and tables which are dynamically generated using Hypertext Preprocessor (PHP) script language. Through building up the relationships between maps, graphs, and databases, this interactive system allows administrators to gain an enhanced understanding of what is occurring in schools, and allow the policy analysts to generate more accurate and effective policy decisions.
Defective neutrophil development and specific granule deficiency caused by a homozygous splice-site mutation in SMARCD2 (2020)

This report highlights an important role for SMARCD2 in human myelopoiesis and the curative effect of hematopoietic stem cell transplantation for the hematopoietic features of SMARCD2 deficiency.
ChemInform Abstract: The Highly Stereocontrolled Radical‐Based Addition of a 2,2‐Dichloroacyl Function to a 2‐Oxazolone Heterocycle. A New Approach to MeBmt, the Key Component of Cyclosporin. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Asymmetric Membranes from Two Chemically Distinct Triblock Terpolymers Blended during Standard Membrane Fabrication (2016)

Deviating from the traditional formation of block copolymer derived isoporous membranes from one block copolymer chemistry, here asymmetric membranes with isoporous surface structure are derived from two chemically distinct block copolymers blended during standard membrane fabrication. As a first proof of principle, the fabrication of asymmetric membranes is reported, which are blended from two chemically distinct triblock terpolymers, poly(isoprene-b-styrene-b-(4-vinyl)pyridine) (ISV) and poly(isoprene-b-styrene-b-(dimethylamino)ethyl methacrylate) (ISA), differing in the pH-responsive hydrophilic segment. Using block copolymer self-assembly and nonsolvent induced phase separation process, pure and blended membranes are prepared by varying weight ratios of ISV to ISA. Pure and blended membranes exhibit a thin, selective layer of pores above a macroporous substructure. Observed permeabilities at varying pH values of blended membranes depend on relative triblock terpolymer composition. These results open a new direction for membrane fabrication through the use of mixtures of chemically distinct block copolymers enabling the tailoring of membrane surface chemistries and functionalities.
Discharge/Charge Characteristics of Li-O2 Batteries Using Noble Metal Catalyst Supported on a Carbon-Free Al-Doped ZnO Cathode (2015)

The composite of noble metals as electrocatalysts and aluminum-doped ZnO (AZO) as a cathode material were combined and developed into a carbon-free cathode material for Li-O2 batteries and their electrochemical performances were investigated. The Ru was the most effective catalyst with AZO and its content was optimized.
Recent Progress in the Energy Recovery Linac Project in Japan (2010)

Future synchrotron light source using a 5-GeV-class energy recovery linac (ERL) is under proposal by our Japanese collaboration team, and we are conducting active R efforts for that. We are developing super-brilliant DC photocathode guns, two types of cryomodules for both injector and main superconducting linacs, 1.3 GHz high CW-power rf sources, and other important components. We are also constructing a compact ERL for demonstrating the recirculation of low-emittance, high-current beams using those key components. We present our recent progress in this project.
Applications of hybrid learning to automated system design (2002)

The evolution of biological systems demonstrates the potential inherent in nonstructured performance-drive design processes for solving difficult design problems. A hybrid learning testbed is described that uses adaptive learning techniques which differ from conventional highly structured AI techniques and instead emulate nature's methods. The testbed incorporates genetic learning, neural networks, and clustering algorithms. The use of these techniques as a means of automating the design of pattern recognition systems is explored. The testbed provides a tangible focus for studying the key components of automated design: model representations, search strategies, and evaluation criteria. It demonstrates how a variety of adaptive techniques can be applied to the automated design of pattern recognition systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Carbon Nanotubes and Spheres Produced by Modified Ferrocene Pyrolysis (2002)

Single-wall carbon nanotubes (SWCNTs) and well-aligned thin multiwall carbon nanotubes (MWCNTs) were successfully synthesized via pyrolysis of a powder mixture of ferrocene and anthracene or 9,10-dibromoanthracene. It is shown that the size of the MWCNTs can be tuned just by changing the ratio of ferrocene/anthracene in the mixture. A lower ratio resulted in low-diameter MWCNTs containing up to five graphene layers only; a high ratio has led to thick MWCNTs with more than 25 layers. Furthermore, there are two extreme cases, the pyrolysis of powders at a low ratio of 1:7 that gives rise to carbon nanospheres and the pyrolysis of pure ferrocene in a H2 flow that mainly gives rise to metal nanoparticles. When powder mixtures of ferrocene and 9,10-dibromoanthracene are pyrolyzed, both SWCNTs and spherical carbon-coated iron nanoparticles are obtained.
Interfacial fracture parameters of silicon-to-molding compound (2010)

The rapid diversification in microelectronics forebodes more complex system integration, be it for denser function integration or a span of dimensions between various technologies. Products may include more features, perform faster and be cheaper. With these trends the amount of material layers is increasing. This challenges development to a faster rating of material pairings. Delamination is a major issue among the related reliability aspects. When the design or testing steps are accompanied by simulation, fracture mechanical descriptions are increasingly proving helpful. The parameters needed for simulation have to be measured and should be available for different fracture mode mix angles. We investigated the interfacial fracture toughness of the Epoxy Molding Compound (EMC) to Silicon interface. Although difficult to delaminate we could carry out measurements using the Mixed Mode Chisel setup (MMC) that allowed us to induce different stress states at the crack tip at various external load angles. The samples we derived from the molding process of embedded wafer level ball grid arrays. Therefore we were able to use samples made with the same process as in real packaging. The crack tip position was determined by analysis of displacement results by digital image correlation. In order to interpret the sample reaction for extracting fracture mechanical parameters, adequate numerical modeling and simulation was required. The experiments provided the parameters for the models. Establishing the residual stress state in the materials preceded the interface delamination simulation: a two step interpretation. Residual stresses cannot be neglected; indeed they are part of the challenges to delaminate this interface at all. We found energy release rates increasing with fracture mode mix, and such values close to pure tensile opening at the crack tip. We recommend to exclude data from short crack lengths and to carefully expose the sample flanks. The results promise to extend the available interfacial fracture data soon.
Cardiomyocyte Polyploidy and Implications for Heart Regeneration (2019)

In mammals, most cardiomyocytes (CMs) become polyploid (they have more than two complete sets of chromosomes). The purpose of this review is to evaluate assumptions about CM ploidy that are commonly discussed, even if not experimentally demonstrated, and to highlight key issues that are still to be resolved. Topics discussed here include (<i>a</i>) technical and conceptual difficulties in defining a polyploid CM, (<i>b</i>) the candidate role of reactive oxygen as a proximal trigger for the onset of polyploidy, (<i>c</i>) the relationship between polyploidization and other aspects of CM maturation, (<i>d</i>) recent insights related to the regenerative role of the subpopulation of CMs that are not polyploid, and (<i>e</i>) speculations as to why CMs become polyploid at all. New approaches to experimentally manipulate CM ploidy may resolve some of these long-standing and fundamental questions.
ChemInform Abstract: Photochemistry of the Nitrogen‐Thiocarbonyl Systems. Part 11. Photoreaction of N‐2‐Alkenylthiophthalimides: 1,4‐Dithiane Formation by Intra‐ and Intermolecular Two‐Fold Photoreactions and the X‐Ray Analysis of the Dithianes. (1987)

Abstract Irradiation of the imides (I) produces a mixture of the stereoisomeric bridged dithianes (II) and (III).
Transient depletion of specific immune cell populations to improve adenovirus‐mediated transgene expression in the liver (2014)

Transient CD4(+) T-cell depletion using antibodies is a clinically feasible procedure that allows efficient Ad redosing. Systemic administration of clodronate liposomes may further increase the safety and efficacy of vectors.
Arthropod Vectors and Vector-Borne Bacterial Pathogens in Yosemite National Park (2011)

Ticks, fleas, and vector-borne pathogens were surveyed in diverse small mammals in Yosemite National Park, California, from 2005 to 2007. A total of 450 unique captures of small mammals was collected during a 3-yr period and yielded 16 species of fleas and 10 species of ticks, including known vectors of Anaplasma phagocytophilum and Borrelia burgdorferi and plague. Serology was performed for A. phagocytophilum, spotted fever group Rickettsia spp., B. burgdorferi, and Yersinia pestis. A. phagocytophilum exposure was identified in 12.1% of all wild small mammals tested, with seropositive animals in 10 species, notably Belding's ground squirrels (Spermophilus beldingi), jumping mice (Zapus princeps), and voles (Microtus sp.). Spotted fever group Rickettsia spp. exposure was detected in 13.9% of all small mammals tested, with seropositive animals in eight species. Additionally, 37.0% of rodents in five species tested were seropositive for B. burgdorferi. No individuals were seropositive for Y. pestis. No animals were polymerase chain reaction positive for any pathogen tested. These results provide baseline data for future research and prediction of emerging vector-borne disease in Yosemite National Park, as well as adding to the known ranges and host species for tick and fleas in California.
A case of fulminant hepatic failure due to cyproterone acetate in a patient with cryptogenic liver cirrhosis (2009)

Cyproterone acetate is an antiandrogenic drug that has been used in prostatic cancer. The drug is thought to be well-tolerated but has hepatotoxic effects. An 89 year-old man treated with cyproterone acetate 300 mg/d for prostatic cancer presented with a hepatotoxic reaction. Toxic hepatitis was diagnosed and cyproterone acetate was stopped immediately. The patient was treated with supportive management and a corticosteroid, but he died 28 days after administration due to liver failure. A liver biopsy performed after his death revealed the presence of acute hepatitis with cirrhosis. Underlying cirrhosis was not suspected before his death. Ultimately, the case was diagnosed as fulminant hepatic failure due to cyproterone acetate with underlying cryptogenic liver cirrhosis. This case and current literature highlight the hepatotoxic potential of cyproterone acetate and illustrate the importance of clinical surveillance, especially in patients with unrecognized liver disease.