gebhart/patrepeval huggingface dataset:
Virtual Texturing (2010)

In this thesis a rendering system and an accompanying tool chain for Virtual Texturing is presented. Our tools allow to automatically retexture existing geometry in order to apply unique texturing on each face. Furthermore we investigate several techniques that try to minimize visual artifacts in the case that only a small amount of pages can be streamed per frame. We analyze the influence of different heuristics that are responsible for the page selection. Alongside these results we present a measurement method to allow the comparison of our heuristics.
A Review of Silicon in Soils and Plants and Its Role in US Agriculture (2016)

Silicon (Si) is the second most abundant element in the earth’s crust and plays a number of important roles in the mineral nutrition of plants. In the past 20 years, the scientific documentation on the benefits of Si to crops has helped establish Si fertilization as an agronomic practice in many agricultural lands worldwide. However, very little information has been consolidated on the use of Si specifically for US agriculture. Consequently, the objectives of this review are to provide (1) information on the dynamics of Si in soil, use, and sources; (2) a history and up-to-date documentation on Si-related research in many areas of US production agriculture; and (3) perspectives on Si as a plant beneficial nutrient and the potential of Si fertilization as an agronomic practice in US crop production systems. The Si-driven mechanisms enhancing the productivity of a wide array of crops under stressed conditions are discussed in this review. Based on the recent 10-year average production level and published shoot Si content, the principal crops grown in the United States can collectively take up 9.55 million tons of Si annually, whereas the annual Si removal rate for the entire US cropland area is estimated at 21.1 million tons. On the basis of this projected annual Si removal rate, adoption of continuous intensive farming systems in the country, low solubility of soil Si, and complex chemical dynamics of Si in soil, increasing plant-available Si levels through fertilization is therefore foreseen a logical agronomic practice for US agriculture.
Anterior lens displacement with age. (1970)

A slight anterior displacement of the lens with age was first postulated by Raeder (1922).
Functional Gene Knockout of NRF2 Increases Chemosensitivity of Human Lung Cancer A549 Cells In Vitro and in a Xenograft Mouse Model (2018)

Recent studies point to the evolution of drug resistance in lung cancer as being centered, at least in part, on the upregulation of various genes involved in controlling efflux or drug inactivation. Among the most important of these genes is Nuclear Factor Erythroid 2-Related Factor (<i>NRF2</i>), considered the master regulator of 100-200 target genes involved in cellular responses to oxidative and/or electrophilic stress. With increased focus on the development of combinatorial approaches for cancer treatment, we utilized CRISPR/Cas9 to disable the <i>NRF2</i> gene in lung cancer cells by disrupting the NRF2 nuclear export signal (NES) domain; phenotypically, the protein is largely blocked from transiting into the nucleus after translation. In tissue culture, cells with this gene knockout were found to have a reduced proliferation phenotype and are more sensitive to chemotherapeutic agents, such as cisplatin and carboplatin. These observations were confirmed in xenograft mouse models wherein the homozygous knockout cells proliferate at a slower rate than the wild-type cells, even in the absence of drug treatment. Tumor growth was arrested for a period of 16 days, with a dramatic decrease in tumor volume being observed in samples receiving the combined action of CRISPR-directed gene editing and chemotherapy.
Neurorobotic fusion of prosthetic touch, kinesthesia, and movement in bionic upper limbs promotes intrinsic brain behaviors (2021)

Bionic prostheses have restorative potential. However, the complex interplay between intuitive motor control, proprioception, and touch that represents the hallmark of human upper limb function has not been revealed. Here, we show that the neurorobotic fusion of touch, grip kinesthesia, and intuitive motor control promotes levels of behavioral performance that are stratified toward able-bodied function and away from standard-of-care prosthetic users. This was achieved through targeted motor and sensory reinnervation, a closed-loop neural-machine interface, coupled to a noninvasive robotic architecture. Adding touch to motor control improves the ability to reach intended target grasp forces, find target durometers among distractors, and promote prosthetic ownership. Touch, kinesthesia, and motor control restore balanced decision strategies when identifying target durometers and intrinsic visuomotor behaviors that reduce the need to watch the prosthetic hand during object interactions, which frees the eyes to look ahead to the next planned action. The combination of these three modalities also enhances error correction performance. We applied our unified theoretical, functional, and clinical analyses, enabling us to define the relative contributions of the sensory and motor modalities operating simultaneously in this neural-machine interface. This multiperspective framework provides the necessary evidence to show that bionic prostheses attain more human-like function with effective sensory-motor restoration.
Late Cenozoic Geology and the Second Oldest Profession (1982)

All soils that are now farmed have been formed or modified by late Cenozoic events. Where these events have been dramatic with glaciers and plate tectonic processes actively intervening, old soils have been obliterated and replaced by newer, inherently more fertile materials. In more placid regions, soils that originated on Tertiary and even Mesozoic landscapes persist, and continue to evolve towards states of low fertility. The inherent fertility of soil, a renewable resource, is largely ignored in modern mechanised agriculture in favour of chemical fertilizers largely mined from non-renewable deposits. A saner attitude once existed, still exists in at least part of the Third World, and should be re-examined as a possible basis for future strategies.
Abstract 4765: MERTK is a potential therapeutic target in osimertinib-resistant non-small cell lung cancer (2019)

Abstract Non-small cell lung cancer (NSCLC) remains a global problem causing more deaths in both men and women than any other cancer worldwide with an urgent need for more efficacious treatments. During the last decade the therapeutic landscape for NSCLC has been profoundly changed with the discovery of activating mutations in Epidermal Growth Factor Receptor (EGFR) (EGFRMT). Osimertinib, a 3rd generation EGFR TKI, was recently FDA-approved as a front-line agent for newly diagnosed EGFRMT NSCLCs due to its superior efficacy relative to earlier-generation EGFR TKIs in the international FLAURA trial. However, unmet clinical needs have arisen in conjunction with osimertinib use, including understanding mechanisms of osimertinib resistance and developing novel approaches to prevent or reverse resistance and/or enhance osimertinib efficacy in responsive patients. Our group previously identified MERTK receptor tyrosine kinase as a potential therapeutic target in NSCLC and developed MRX-2843, a novel small molecule inhibitor with dual MERTK and FLT3 activity, which is currently in Phase I clinical trials. Here, we report upregulation of MERTK and its ligand PROS1 in xenograft tumors derived from the EGFRMT H4006 NSCLC cell line and treated with osimertinib relative to vehicle-treated tumors. MERTK expression was also increased in osimertinib-resistant derivatives of the H4006 and H4011 cell lines generated by culture in escalating doses of osimertinib. However, overexpression of exogenous MERTK in H4006 cells was not sufficient to confer osimertinib resistance. In contrast, stimulation with TAM kinase ligands GAS6 or PROS1 protected H4006 cells from osimertinib treatment, as indicated by restoration of AKT, ERK, and ribosomal S6 phosphorylation in the presence of osimertinib. Together these data implicate MERTK as a mediator of resistance to osimertinib. Indeed, combined treatment with osimertinib and MRX-2843 effectively blocked PI3K-AKT and MAPK-ERK signaling and mediated synergistic inhibition of colony formation in osimertinib-resistant H4006 cells. Thus, MERTK inhibition may be an effective therapeutic strategy to re-sensitize osimertinib-resistant NSCLCs to EGFR TKI treatment. Citation Format: Dan Yan, Justus Huelse, Rebecca Parker, Xiaodong Wang, Stephen V. Frye, H. Shelton Earp, Deborah DeRyckere, Douglas Graham. MERTK is a potential therapeutic target in osimertinib-resistant non-small cell lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4765.
Molybdenum/pure aluminum gate bus line defect reduction for high-resolution thin film transistor liquid crystal displays (2003)

Defect mode analysis for pure aluminum was done to improve fabrication of very large high-resolution thin film transistor liquid crystal displays with very low gate line delay. Mouse hole defects in pure aluminum films are caused by the stress voiding due to the heating/cooling process and by vacancy diffusion. An oxygen treatment between the molybdenum and aluminum depositions is very effective in completely suppressing mouse hole formation. An additive material is also effective in suppressing mouse holes because of the reduction in grain size and the vacancy pinning. Blisters are created during heating processes and can be suppressed by using a MoTa/Mo/aluminum structure or by removal of the undercoat layer.
Infinite Groups 1994 (1996)

The series is aimed specifically at publishing peer reviewed reviews and contributions presented at workshops and conferences. Each volume is associated with a particular conference, symposium or workshop. These events cover various topics within pure and applied mathematics and provide up-to-date coverage of new developments, methods and applications.
Novel cooling technique for operation of quasi four-level solid-state laser (2005)

We report a novel cooling technique for solid-state laser, which provides opportunity for liquid nitrogen temperature. The cooling holder does not have any windows on the laser beam path in order to minimize dispersion-related effects and nonlinear absorption under femtosecond laser operation. cw laser oscillation of 4% Yb<sup>3+</sup>-doped Y<sub>2</sub>O<sub>3</sub> ceramics at 120 K temperature and 450 mW output power at 1030 nm, as obtained.
Both the Structure and DNA Binding Function of the Barrier-to-Autointegration Factor Contribute to Reconstitution of HIV Type 1 Integration in Vitro (2000)

Retroviral integration is mediated by viral preintegration complexes (PICs), and human immunodeficiency virus type 1 (HIV-1) PICs treated with high salt lose their in vitro integration activity. Barrier-to-autointegration factor (BAF) is a host protein that efficiently restores PIC activity, but the mechanism(s) by which BAF participates in HIV-1 integration remains largely unknown. Here we developed a gel shift assay to study BAF DNA binding, and analyzed 14 mutant proteins containing substitutions of conserved residues for binding and PIC reconstitution activities. Although wild-type BAF efficiently bound double-stranded DNA, binding to single-stranded DNA, RNA, or an RNA/DNA hybrid was not detected, suggesting that BAF associates with retroviral cDNA relatively late during reverse transcription. Although some of the BAF mutant proteins efficiently bound DNA, others were defective for binding. Mutants that bound DNA efficiently reconstituted HIV-1 integration, even though in one case binding was just 0.2% of wild-type BAF. Although misfolded mutants did not reconstitute integration, a structurally intact DNA binding-defective mutant displayed partial activity at high BAF concentration. We therefore conclude that both BAF protein structure and its DNA binding activity play roles in reconstituting HIV-1 integration in vitro.
Comparison of Rates of Positivity for Bordetella pertussis by Real-Time PCR between Specimens Collected with Rayon Swabs on Aluminum Wire Shaft in Amies Gel with Charcoal and Specimens Collected with Flocked Swabs in Universal Viral Transport Medium during an Epidemic (2014)

A comparison of real-time PCR positivity rates for Bordetella pertussis between specimens collected with rayon swabs on an aluminum wire shaft in Amies gel with charcoal and those collected with flocked swabs in universal viral transport medium during an epidemic revealed that their performances were comparable.
Data from MUC4 Mucin Potentiates Pancreatic Tumor Cell Proliferation, Survival, and Invasive Properties and Interferes with Its Interaction to Extracellular Matrix Proteins (2023)

&lt;div&gt;Abstract&lt;p&gt;MUC4, a transmembrane mucin, is aberrantly expressed in pancreatic adenocarcinomas while remaining undetectable in the normal pancreas. Recent studies have shown that the expression of &lt;i&gt;MUC4&lt;/i&gt; is associated with the progression of pancreatic cancer and is inversely correlated with the prognosis of pancreatic cancer patients. In the present study, we have examined the phenotypic and molecular consequences of &lt;i&gt;MUC4&lt;/i&gt; silencing with an aim of establishing the mechanistic basis for its observed role in the pathogenesis of pancreatic cancer. The silencing of &lt;i&gt;MUC4&lt;/i&gt; expression was achieved by stable expression of a &lt;i&gt;MUC4&lt;/i&gt;-specific short hairpin RNA in CD18/HPAF, a highly metastatic pancreatic adenocarcinoma cell line. A significant decrease in &lt;i&gt;MUC4&lt;/i&gt; expression was detected in &lt;i&gt;MUC4&lt;/i&gt;-knockdown (CD18/HPAF-siMUC4) cells compared with the parental and scrambled short interfering RNA–transfected (CD18/HPAF-Scr) control cells by immunoblot analysis and immunofluorescence confocal microscopy. Consistent with our previous observation, inhibition of &lt;i&gt;MUC4&lt;/i&gt; expression restrained the pancreatic tumor cell growth and metastasis as shown in an orthotopic mouse model. Our &lt;i&gt;in vitro&lt;/i&gt; studies revealed that MUC4-associated increase in tumor cell growth resulted from both the enhanced proliferation and reduced cell death. Furthermore, &lt;i&gt;MUC4&lt;/i&gt; expression was also associated with significantly increased invasiveness (&lt;i&gt;P&lt;/i&gt; ≤ 0.05) and changes in actin organization. The presence of MUC4 on the cell surface was shown to interfere with the tumor cell-extracellular matrix interactions, in part, by inhibiting the integrin-mediated cell adhesion. An altered expression of growth- and metastasis-associated genes (&lt;i&gt;LI-cadherin, CEACAM6, RAC1, AnnexinA1, thrombomodulin, epiregulin, S100A4, TP53, TP53BP, caspase-2, caspase-3, caspase-7, plakoglobin&lt;/i&gt;, and &lt;i&gt;neuregulin-2&lt;/i&gt;) was also observed as a consequence of the silencing of &lt;i&gt;MUC4&lt;/i&gt;. In conclusion, our study provides experimental evidence that supports the functional significance of MUC4 in pancreatic cancer progression and indicates a novel role for MUC4 in cancer cell signaling. (Mol Cancer Res 2007;5(4):309–20)&lt;/p&gt;&lt;/div&gt;
Electrical properties of silicon implanted with boron ions of MeV energy (1973)

Abstract Buried p +-type layers have been produced in silicon substrates by implanting boron ions of 3 or 8 MeV with doses of 1012-3·1014 cm−2 Experimental techniques such as junction staining, capacitance-voltage and electrical sheet measurements, have been used to evaluate carrier concentration profiles, electrical activity, and effective mobility of the buried layers as a function of temperature in the range of 350-1000°C.
Attempt to Control Spatial Distribution of Nano-Gold Particles Using Nanoporous Surfaces of FeAl Single Crystal (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
An Epistle for Two (1970)

Journal Article An Epistle for Two Get access ARTHUR FREEMAN ARTHUR FREEMAN Cambridge, Massachusetts Search for other works by this author on: Oxford Academic Google Scholar The Library, Volume s5-XXV, Issue 3, September 1970, Pages 226–236, https://doi.org/10.1093/library/s5-XXV.3.226 Published: 01 September 1970
Adaptive Power Control with Online Model Estimation for Chip Multiprocessors (2011)

As chip multiprocessors (CMPs) become the main trend in processor development, various power and thermal management strategies have recently been proposed to optimize system performance while controlling the power or temperature of a CMP chip to stay below a constraint. The availability of per-core dynamic voltage and frequency scaling (DVFS) also makes it possible to develop advanced management strategies. However, most existing solutions rely on open-loop search or optimization with the assumption that power can be estimated accurately, while others adopt oversimplified feedback control strategies to control power and temperature separately, without any theoretical guarantees. In this paper, we propose a chip-level power control algorithm that is systematically designed based on optimal control theory. Our algorithm can precisely control the power of a CMP chip to the desired set point while maintaining the temperature of each core below a specified threshold. Furthermore, an online model estimator is designed to achieve analytical assurance of control accuracy and system stability, even in the face of significant workload variations or unpredictable chip or core variations. To further improve system performance, we also integrate dynamic cache resizing into our control framework so that power can be shifted among CPU cores and the shared L2 cache. Empirical results on a physical testbed show that our controller outperforms two state-of-the-art control algorithms by having better SPEC benchmark performance and more precise power control. In addition, extensive simulation results demonstrate the efficacy of our algorithm for various CMP configurations.
The real alternative? A comparison of German real estate returns with bonds and stocks (2017)

Purpose The purpose of this paper is to evaluate how real estate returns behaved over the last two decades in relation to the other two asset types. This allows a direct evaluation of how investors make allocation choices and perceive risks and rewards offered by properties in the context of changing market conditions. Design/methodology/approach A de-smoothed MSCI index is used to reflect direct property returns and control for both income and capital returns within it. Indirect property returns are approximated by the RX Real Estate index. By supplementing this data with an analysis of trends in both space and capital markets it is possible to relate investor behavior to events affecting other assets. Findings It is possible to identify three distinctive periods characterized by different correlation of returns and behavior of investors: before the crisis of 2008, the crisis period between 2008 and 2012 and recovery afterwards. These appear to have corresponded to different stages of the economic cycle. Interestingly, performance of asset classes has also differed over that period suggesting that at different points in the cycle asset allocation decisions may have been made differently. Practical implications It appears that as investments over the last 15 years real assets in Germany behaved similarly to bonds. It is possible that this phenomenon was driven by an aversion to the stock market and its associated risk which became a concern after the financial crisis of 2008. Over the downturn that followed the market shock investors appear to have turned to assets with simpler risk profiles like direct real estate and government debt. On the other hand, the correlation between direct property investment index and stock returns has been found to be small but negative. This shows not only that the two asset classes were often driven by different factors but also suggests that diversification was, at least theoretically, possible. Originality/value Direct real estate investment returns have repeatedly been found to exhibit characteristics similar to those found in bond as well as equity markets (Eichholtz and Hartzell, 1996; Clayton and MacKinnon, 2003) but little research examines the correlation between returns offered by those asset classes in a mature financial and property market. In addition, the recent financial crisis provided a dynamically changing investment which is ideal for investigating structural relationships between assets.
A Signaling Lipid Associated with Alzheimer’s Disease Promotes Mitochondrial Dysfunction (2016)

Fundamental changes in the composition and distribution of lipids within the brain are believed to contribute to the cognitive decline associated with Alzheimer's disease (AD). The mechanisms by which these changes in lipid composition affect cellular function and ultimately cognition are not well understood. Although "candidate gene" approaches can provide insight into the effects of dysregulated lipid metabolism they require a preexisting understanding of the molecular targets of individual lipid species. In this report we combine unbiased gene expression profiling with a genome-wide chemogenomic screen to identify the mitochondria as an important downstream target of PC(O-16:0/2:0), a neurotoxic lipid species elevated in AD. Further examination revealed that PC(O-16:0/2:0) similarly promotes a global increase in ceramide accumulation in human neurons which was associated with mitochondrial-derived reactive oxygen species (ROS) and toxicity. These findings suggest that PC(O-16:0/2:0)-dependent mitochondrial dysfunction may be an underlying contributing factor to the ROS production associated with AD.
Management of all-optical WDM networks: First results of European research project MOON (2002)

This paper presents first results of the European research project MOON. It is organized as follows. As a starting point, basic concepts of all-optical networks which are relevant for management are described. The results are compared with the Synchronous Digital Hierarchy (SDH) which is the state-of-the-art transport technique. Then, the general architecture for a TMN conforming management of all-optical networks is illustrated. As a main point of the paper, the impact of transparency limitations on transmission, OAM (operation, administration, maintenance), and management is discussed. A functional architecture will be presented which describes the network in a formalized way. Based on this description, different approaches for the transmission of OAM overhead are addressed. The information model of MOON is described and compared to the SDH model. Finally, concepts for the implementation of the management system are presented.