gebhart/patrepeval huggingface dataset:
Apolipoprotein B48 metabolism in chylomicrons and very low‐density lipoproteins and its role in triglyceride transport in normo‐ and hypertriglyceridemic human subjects (2019)

The intestine secretes apoB48-containing particles not only as chylomicrons but also directly into the VLDL<sub>1</sub> and VLDL<sub>2</sub> density ranges both in the basal state and during dietary lipid absorption. Over the day, apoB48-containing particles appear to comprise about 20-25% of circulating VLDL and, especially in those with elevated triglycerides, form part of a slowly cleared 'remnant' particle population, thereby potentially increasing CHD risk. These findings provide a metabolic understanding of the potential consequences for increased CHD risk when slowed lipolysis leads to the accumulation of remnants, especially in individuals with hypertriglyceridemia.
Lowfat Ice Creams from Freeze-Concentrated Versus Heat-Concentrated Nonfat Milk Solids (1995)

Lowfat vanilla ice creams made from freeze-or heat-concentrated nonfat milk solids were compared in sensory and physical tests. Results did not support the hypothesis that lowfat ice cream made from freeze-concentrated nonfat milk solids would be smoother, ftrrner, slower to melt, lower in cooked flavor, and higher in vanilla flavor than lowfat ice cream made from heat-concentrated nonfat milk solids. Nonfat dry milk solids imparted slightly more smoothness than did dried freeze-concentrated nonfat milk solids. Otherwise, heatconcentrated versus freeze-concentrated products had no effects on sensory attributes when comparisons of liquid and dried forms of the products were made separately. Products from both liquid and dry sources of both types of nonfat milk solids differed little in sensory quality. Apparent viscosity of the mixes and the hardness and melting rate of the frozen products were affected by the source of nonfat milk solids. (
ICP Emission Spectrometry: On the Selection of Analytical Lines, Line Coincidence Tables, and Wavelength Tables (1982)

A thorough knowledge of the spectral emission characteristics of the inductively coupled plasma is a prerequisite for its maximum utilization in atomic emission spectroscopy. Toward this end an Atlas of Spectral Information for Inductively Coupled Plasma, Atomic Emission Spectroscopy has been assembled to provide the analyst with the basic information concerning the analytical capabilities and the potential spectral interferences of the prominent spectral lines of 70 elements. The Atlas contains 232 wavelength scans of 70 elements covering the range of 189 to 517 nm (189 to 597 nm for sodium and the reference blank). The Atlas also contains a listing of 973 prominent lines with estimated detection limits and a detailed collection of coincidence profiles for 281 of the most prominent lines, each with profiles of ten of the most prevalent concomitant elements superimposed. This paper contains a survey of the spectral information contained in the Atlas.
Radical Protection by Sunscreens in the Infrared Spectral Range (2010)

One essential reason for skin ageing is the formation of free radicals by excessive or unprotected sun exposure. Recently, free radical generation in skin has been shown to appear not only after irradiation in the UV wavelength range but also in the infrared (IR) spectral range. Sunscreens are known to protect against radicals generated by UV radiation; however, no data exist for those generated by IR radiation. This paper has investigated four different, commercially available sunscreens and one COLIPA standard with regard to radical formation in the skin after IR irradiation, using electron paramagnetic resonance spectroscopy. The use of sunscreens has led to reduced amounts of radicals compared to untreated skin. Furthermore, absorption and scattering properties and the radical protection factor of the formulations were determined to investigate their influence on the radical protection of the skin. None of these formulations contained an optical absorber in the IR range. The protection efficiency of the sunscreens was shown as being induced by the high scattering properties of the sunscreens, as well as the antioxidants contained in the formulations.
SB-IGFET, II: An ion implanted IGFET using Schottky barriers (1969)

Insulated-gate field-effect transistors have been made, which combine the advantages inherent to Schottky barrier source and drain electrodes with ion implantation. This device has a self-aligned gate structure achieved by using the thick gate electrode as a mask during the ion implantation process.
European Respiratory Society guidelines on long-term home non-invasive ventilation for management of COPD (2019)

Background While the role of acute non-invasive ventilation (NIV) has been shown to improve outcome in acute life-threatening hypercapnic respiratory failure in COPD, the evidence of clinical efficacy of long-term home NIV (LTH-NIV) for management of COPD is less. This document provides evidence-based recommendations for the clinical application of LTH-NIV in chronic hypercapnic COPD patients. Materials and methods The European Respiratory Society task force committee was composed of clinicians, methodologists and experts in the field of LTH-NIV. The committee developed recommendations based on the GRADE (Grading, Recommendation, Assessment, Development and Evaluation) methodology. The GRADE Evidence to Decision framework was used to formulate recommendations. A number of topics were addressed under a narrative format which provides a useful context for clinicians and patients. Results The task force committee delivered conditional recommendations for four actionable PICO (target population-intervention-comparator-outcome) questions, 1) suggesting for the use of LTH-NIV in stable hypercapnic COPD; 2) suggesting for the use of LTH-NIV in COPD patients following a COPD exacerbation requiring acute NIV 3) suggesting for the use of NIV settings targeting a reduction in carbon dioxide and 4) suggesting for using fixed pressure support as first choice ventilator mode. Conclusions Managing hypercapnia may be an important intervention for improving the health outcome of COPD patients with chronic respiratory failure. The task force conditionally supports the application of LTH-NIV to improve health outcome by targeting a reduction in carbon dioxide in COPD patients with persistent hypercapnic respiratory failure. These recommendations should be applied in clinical practice by practitioners that routinely care for chronic hypercapnic COPD patients.
Aberrant Inflammation and Lethality to Septic Peritonitis in Mice Lacking STAT3 in Macrophages and Neutrophils (2003)

Stat3 is a transcription factor mediating anti-inflammatory properties of IL-10. In the present study, we demonstrate a pivotal role of Stat3 expressed in innate immune cells during septic peritonitis induced by cecal ligation and puncture (CLP). Mice with targeted disruption of Stat3 in macrophages and neutrophils were succumbed to septic peritonitis induced by CLP. The mice displayed an excessive local and systemic inflammation relative to the control mice, an event that was accompanied by substantial increases in the level of multiple cytokines. Hepatic and renal injury was significantly exacerbated in mice with Stat3 deficiency. Despite enhanced inflammatory responses, the mice failed to facilitate bacterial clearance as compared with the control mice. In addition, the mice exhibited an increased lethality after i.p. inoculation of live bacteria recovered from CLP-mice. In vitro, resident peritoneal macrophages from mice with Stat3 deficiency impaired bactericidal activity relative to the control whereas productions of inflammatory cytokines were significantly augmented when cells were stimulated with a synthetic lipopeptide, macrophage-activating lipopeptide-2 and LPS. Elicited macrophages and neutrophils with Stat3 deficiency also impaired bactericidal activity as compared with those with Stat3. Lysosomal enzyme release, an effector molecule for bacterial clearance, was significantly decreased in elicited leukocytes with Stat3 deficiency while increasing the production of inflammatory cytokines. Altogether, these results suggest that macrophage/neutrophil-specific STAT3 is crucial in not only modulating multiple organ failure associated with systemic inflammation but also intensifying the bactericidal activity, which highlight the significance of cell-specific Stat3 in the protective immunity during sepsis.
SDRAM Delay Fault Modeling and Performance Testing (2007)

DRAM timing parameter testing has always been considered a time-consuming process. This paper presents a systematic approach to analysis and classification of the synchronous DRAM (SDRAM) delay failure modes. Four delay fault models with March expression are proposed to cover important DRAM timing parameters. By at-speed March testing of these four types of delay faults, the authors can verify the DRAM timing specifications.
Poly(phthalidylidenearylene)s. Gelation in the homopolycondensation of 3‐aryl‐3‐chlorophthalides (1993)

Abstract The Friedel‐Crafts homopolycondensations of 3‐(4‐biphenyly)‐3‐chlorophthalide ( 1 a ), 3‐(2‐fluorenyl)‐3‐chlorophthalide ( 1 b ), 3‐(4‐phenoxyphenyl)‐3‐chlorophthalide ( 1 c ), 3‐(4‐phenylthiophenyl)‐3‐chlorophthalide ( 1 d ) were studied. The homopolycondensation of 1 a was found to give linear, fully soluble polymers. A gelation, depending on reaction parameters, can occur in the reactions of 1 b – 1 d . The methylene group of 1 b was shown to be reactive in the course of synthesis, giving cross‐links. Using the NMR pulsed gradient spin echo method, it was found, that degradation of macromolecular chains in the homopolycondensation of 1 c is followed by gelation. A proposed mechanism of gelation is based on the transformation of intermediate acyloxonium complexes. Similar transformations of acyl‐sulfonium complexes are suggested to occur in the course of the homopolycondensation of 1 d .
Transient response of tapping scanning force microscopy in liquids (1996)

Tapping-mode scanning force microscopy in liquids is usually accomplished by acoustic excitation of the cantilever because of the strong viscous damping. Contact of the tip with the sample surface results in a damping of the cantilever amplitude with an anharmonic response. This interaction is modeled as a viscous-damped, one-dimensional harmonic oscillator periodically perturbed by an exponential surface potential. Experimental results verify the validity of the model.
Melt polymer drawn single and multi-capillary fibre-based electroosmotic pumps (2022)

Abstract Microfluidic devices have been employed in micro-analytical systems and microelectronics using inexpensive, customisable fluid-handling automation at the microliter scale. Here we utilise a well-established fibre drawing technique, which offers a range of materials and capillary conformations, that can be utilized within microfluidic devices to control fluid movement via electroosmotic processes to produce a simple electroosmotic pump (EOP). Single capillary EOPs were fabricated from drawn PU capillary fibres with internal diameters ranging from 73 to 200 µm and were shown to be capable of actively transporting a buffer solution using an external driving electric potential. A maximum flow rate of 0.8 ± 0.1 μL/min was achieved for a 73 ± 2 µm diameter PU capillary fibre at an applied potential of 750 V/cm. This flow rate was successfully increased up to 5.3 ± 0.3 μL/min by drawing a multi-capillary array consisting of 4, 5 and 7 capillaries.
Mapping of spinal cord circuits controlling the bladder and external urethral sphincter functions in the rabbit (2004)

Overall, the results indicate that spinal cord networks controlling bladder and EUS activation in the rabbit are overlapping and clustered into columns extending rostrocaudally. The lack of spinal locations producing EUS inhibition and large bladder contractions make the rabbit an unattractive model for studies of neuroprosthetic spinal control of micturition.
Backwards Lasing from Krypton in Atmospheric Air (2020)

We present first evidence of backwards lasing from Krypton present in atmospheric air. Two-photon femtosecond UV excitation leads to stimulated emission at 759nm. The air laser can be used for standoff detection.
Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles (2018)

Collectively, our results indicate that ciliary vesicles may represent a novel mode of intercellular communication within tumors that contributes to GBM pathogenesis. The mitogenic capacity of GBM ciliary vesicles and the molecular mediators of this phenomenon requires further investigation.
Atrazine-Selective Polymers Prepared by Molecular Imprinting of Trialkylmelamines as Dummy Template Species of Atrazine (2000)

Synthetic polymer receptors selective for atrazine have been prepared by molecular imprinting using trialkylmelamines as template molecules in place of atrazine. Trialkylmelamines were shown to be useful as templates for introducing affinity for atrazine into ethylene glycol dimethacrylate-methacrylic acid copolymers. The polymers showed the selective binding capacity for triazine herbicides including atrazine, whereas agrochemicals in other categories were not adsorbed to the imprinted polymers. The group selectivity demonstrated was comparable with that of the original atrazine imprinted polymers. Use of the nonagrochemical template molecules as a substitution to atrazine has made it possible to synthesize herbicide-receptor polymers free from troubles caused by analyte contaminants, which are desired for analytical applications.
Carbon‐13 nmr spectra of the tRNA “wobble” nucleosides 5‐carboxymethyl‐, 5‐carbomethoxymethyl‐, and 5‐carbamoylmethyluridine (1980)

Abstract The 13 C nmr chemical shifts have been measured for 5‐carboxymethyluracil 2 , 5‐carbo‐methoxymethyluracil 3 , their 2‐thio derivatives 4 and 5 , respectively, as well as of the three β‐D‐ribonucleosides, 5‐carboxymethyluridine 7 , 5‐carbomethoxymethyluridine 8 , and 5‐carbamoyl‐methyluridine 9 . In addition, the 13 C‐ 1 H coupling constants for 2 and 7 have, also been obtained.
Random Oracles and Auxiliary Input. (2007)

Abstract. We introduce a variant of the random oracle model where oracle-dependent auxiliary input is allowed. In this setting, the adversary gets an auxiliary input that can contain information about the random oracle. Using simple examples we show that this model should be preferred over the classical variant where the auxiliary input is independent of the random oracle. In the presence of oracle-dependent auxiliary input, the most important proof technique in the random oracle model—lazy sampling—does not apply directly. We present a theorem and a variant of the lazy sampling technique that allows one to perform proofs in the new model almost as easily as in the old one. As an application of our approach and to illustrate how existing proofs can be adapted, we prove that
Insights into rumen microbial biosynthetic gene cluster diversity through genome-resolved metagenomics (2020)

Abstract Ruminants are critical to global food security as they transform lignocellulosic biomass into high-quality protein products. The rumen microbes ferment feed to provide necessary energy and nutrients for the ruminant host. However, we still lack insight into the metabolic processes encoded by most rumen microbial populations. In this study, we implemented metagenomic binning approaches to recover 2,809 microbial genomes from cattle, sheep, moose, deer, and bison. By clustering genomes based on average nucleotide identity, we demonstrate approximately one-third of the metagenome-assembled genomes (MAGs) to represent species not present in current reference databases and rumen microbial genome collections. Combining these MAGs with other rumen genomic datasets permitted a phylogenomic characterization of the biosynthetic gene clusters (BGCs) from 8,160 rumen microbial genomes, including the identification of 5,346 diverse gene clusters for nonribosomal peptide biosynthesis. A subset of Prevotella and Selenomonas BGCs had higher expression in steers with lower feed efficiency. Moreover, the microdiversity of BGCs was fairly constant across types of BGCs and cattle breeds. The reconstructed genomes expand the genomic representation of rumen microbial lineages, improve the annotation of multi-omics data, and link microbial populations to the production of secondary metabolites that may constitute a source of natural products for manipulating rumen fermentation.
Perfect-Frequency-Converter Metasurface Consisting of Twin Time-Modulated Radiators (2020)

We introduce a perfect-frequency-converter meta-surface based on the effects of inharmonic photonic transition in twin time-modulated radiating patches. The medium is characterized with a periodic temporal modulation and a tailored aperiodic spatial profile. Such an aperiodic spatial profile provides aperiodic photonic bandgaps which prevent photonic transitions to unwanted time harmonics. Full-wave simulation results demonstrate a pure frequency conversion. The unique property of the proposed platform is the large frequency difference between the incident and transmitted waves. Therefore, this makes it suitable for modern wireless telecommunication systems.
PARANEOPLASTIC SYNDROMES AFFECTING THE CENTRAL NERVOUS SYSTEM (1997)

Paraneoplastic syndromes affecting the nervous system are rare neurologic syndromes caused by cancer but not ascribable to metastases. Any portion of the nervous system may be involved in a paraneoplastic syndrome. The pathogenesis of these disorders appears to be an immune reaction against antigens shared by the cancer and the nervous system. Some disorders, such as the Lambert-Eaton myasthenic syndrome, are effectively treated by removal of autoantibodies directed against the presynaptic cholinergic synapse. In other disorders, such as paraneoplastic cerebellar degeneration or paraneoplastic sensory neuronopathy, neither removal of the autoantibody nor treatment of the cancer is effective.
Computational analysis of the transcriptional regulation of pentose utilization systems in the gamma subdivision of Proteobacteria (2001)

The comparative approach to the recognition of transcription regulatory sites is based on the assumption that as long as a regulator is conserved in several genomes, one can expect that sets of co-regulated genes (regulons) and regulatory sites for the regulator in these genomes are conserved as well. We used this approach to analyze the ribose (RbsR), arabinose (AraC), and xylose (XylR) regulons of gamma Proteobacteria for which (almost) completely sequenced genomes were available. Candidate binding sites for RbsR and AraC were detected. The improved XylR site consensus was proposed. Potential new members of the xylose regulons were found in the Escherichia coli, Salmonella typhi, and Klebsiella pneumoniae genomes. The function of these new xylose-regulated operons is likely to be the utilization of oligosaccharides containing xylose. Finally, candidate cAMP receptor-protein sites were identified in the regulatory regions of the majority of RbsR-, AraC-, and XylR-regulated operons.
Achondroplasia: pathogenesis and implications for future treatment (2010)

Current research into the pathogenesis of achondroplasia has expanded our understanding of the mechanisms of FGFR3-induced disease and has increased the number of approaches that we may use to potentially correct it. Further research is needed to validate these approaches in preclinical models of achondroplasia.
MINORITY CARRIER LIFETIME IN ION-IMPLANTED AND ANNEALED SILICON (1970)

Results are presented of an investigation to determine whether minority carrier lifetime within ion-implanted layers can be restored to preirradiation levels by annealing. Reverse-recovery measurements were conducted on diffused diodes damaged on the low-doped side by light doses of carbon. The results show that practically complete recovery can be obtained, but annealing beyond the 400°C range associated with light-dose lattice reordering to as high as 600–650°C is required.
Electric field effect in a conducting binary critical mixture (1980)

Abstract We investigate the change in the concentration-concentration correlation function to lowest order in an electric field, when the electric field is applied to a conducting binary critical mixture so that power is dissipated. We obtain an estimate of the size of the electric field, as a function of temperature, which must be applied in order that an appreciable effect is obtained. We briefly apply our results to a critical mixture of isobutyric acid and water.
Supplementary Figure 1 from A Phase I/II, Multiple-Dose, Dose-Escalation Study of Siltuximab, an Anti-Interleukin-6 Monoclonal Antibody, in Patients with Advanced Solid Tumors (2023)

&lt;p&gt;PDF file - 25KB, Supplementary Figure S1. Patient disposition: AE, adverse event. KRAS, Kirsten rat sarcoma-2. PD, progressive disease. q2w, every 2 weeks. q3w, every 3 weeks.&lt;/p&gt;
Distribution and subunit structure of insulin receptors in rat renal glomeruli (1989)

Conference Article| August 01 1989 Distribution and subunit structure of insulin receptors in rat renal glomeruli DAVID C. W. MURRAY; DAVID C. W. MURRAY *Division of Biochemistry, U.M. D.S. (St Thomas's Hospital), London SE1 7EH, U.K. Search for other works by this author on: This Site PubMed Google Scholar DIETRICH BRANDENBURG; DIETRICH BRANDENBURG †Deutsches Wollforschungsinstitut, D-5100 Aachen, F.R.G. Search for other works by this author on: This Site PubMed Google Scholar J. HYWEL THOMAS J. HYWEL THOMAS *Division of Biochemistry, U.M. D.S. (St Thomas's Hospital), London SE1 7EH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1989) 17 (4): 652. https://doi.org/10.1042/bst0170652 Article history Received: November 25 1988 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation DAVID C. W. MURRAY, DIETRICH BRANDENBURG, J. HYWEL THOMAS; Distribution and subunit structure of insulin receptors in rat renal glomeruli. Biochem Soc Trans 1 August 1989; 17 (4): 652. doi: https://doi.org/10.1042/bst0170652 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: Napa, 2-nitro, 4-azidophenylacetyl This content is only available as a PDF. © 1989 Biochemical Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Lewis Acid Catalysis in Aqueous Media (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Adaptive algorithms for constrained ARMA signals in the presence of noise (2005)

A new family of algorithms is developed for adaptive parameter estimation of constrained autoregressive moving-average (ARMA) signals in the presence of noise. These algorithms utilize a priori known information concerning the signal's properties, such as its spectral shape or a spatial domain characteristic. Special cases include autoregressive (AR) and band-pass spectrum signals in the presence of noise, signal deconvolution and image deblurring.