gebhart/patrepeval huggingface dataset:
Caspase-1 Contributes toChlamydia trachomatis-Induced Upper Urogenital Tract Inflammatory Pathologies without Affecting the Course of Infection (2007)

Chlamydia trachomatis infection induces inflammatory pathologies in the upper genital tract, potentially leading to ectopic pregnancy and infertility in the affected women. Caspase-1 is required for processing and release of the inflammatory cytokines interleukin-1beta (IL-1beta), IL-18, and possibly IL-33. In the present study, we evaluated the role of caspase-1 in chlamydial infection and pathogenesis. Although chlamydial infection induced caspase-1 activation and processing of IL-1beta, mice competent and mice deficient in caspase-1 experienced similar courses of chlamydial infection in their urogenital tracts, suggesting that Chlamydia-activated caspase-1 did not play a significant role in resolution of chlamydial infection. However, when genital tract tissue pathologies were examined, the caspase-1-deficient mice displayed much reduced inflammatory damage. The reduction in inflammation was most obvious in the fallopian tube tissue. These observations demonstrated that although caspase-1 is not required for controlling chlamydial infection, caspase-1-mediated responses can exacerbate the Chlamydia-induced inflammatory pathologies in the upper genital tract, suggesting that the host caspase-1 may be targeted for selectively attenuating chlamydial pathogenicity without affecting the host defense against chlamydial infection.
Exceptionally high genetic variance of the doubled haploid (DH) population of poplar (2023)

Abstract Doubled haploid (DH) plants have been widely used for breeding and biological research in crops. Populus spp. have been used as model woody plant species for biological research. However, the induction of DH poplar plants is onerous, and limited biological or breeding work has been carried out on DH individuals or populations. In this study, we provide an effective protocol for poplar haploid induction based on an anther culture method. A total of 96 whole DH plant lines were obtained using an F 1 hybrid of Populus simonii × P. nigra as a donor tree. The phenotypes of the DH population showed exceptionally high variance when compared to those of half-sib progeny of the donor tree. Each DH line displayed distinct features compared to those of the other DH lines or the donor tree. Additionally, some excellent homozygous lines have the potential to be model plants in genetic and breeding studies.
Effect of the interface on femtosecond laser damage of a metal-dielectric low dispersion mirror (2021)

Metal-dielectric low dispersion mirrors (MLDM) have a promising application prospect in petawatt (PW) laser systems. We studied the damage characteristics of MLDM and found that the damage source of MLDM (Ag + Al<sub>2</sub>O<sub>3</sub>+SiO<sub>2</sub>) is located at the metal-dielectric interface. We present the effect of the interface on the femtosecond laser damage of MLDM. Finite element analysis shows that thermal stress is distributed at the interface, causing stress damage which is consistent with the damage morphology. After enhancing the interface adhesion and reducing the residual stress, the damage source transfers from the interface to a surface SiO<sub>2</sub> layer, and the damage threshold can be increased from 0.60 J/cm<sup>2</sup> to 0.73 J/cm<sup>2</sup>. This work contributes to the search for new techniques to improve the damage threshold of MLDM used in PW laser systems.
Supplementary Figure 1 from Proangiogenic Factor PlGF Programs CD11b<sup>+</sup> Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors (2023)

Supplementary Figure 1 from Proangiogenic Factor PlGF Programs CD11b&lt;sup&gt;+&lt;/sup&gt; Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Development of polymer coatings for the ProSEDS tether (2000)

The ProSEDS mission is designed to provide an on-orbit demonstration of the electrodynamic propulsion capabilities of tethers in space. The ProSEDS experiment will be a secondary payload on a Delta 11 unmanned, expendable booster. A 5 km conductive tether is attached to the deployer baseplate on the Delta 11 second stage and collects current from the low Earth orbit (LEO) plasma to facilitate de-orbit of the Delta II second stage. The conductive tether is attached to a 10-15 km non-conductive tether, which in turn is attached to an endmass. A bare metal tether would have the best conductivity but thermal concerns preclude this design. A conductive polymer developed by Triton Systems has been optimized for optimum conductivity and thermo-optical properties. The current design for the ProSEDS conductive tether is seven individually coated strands of 28 AWG aluminum wire, coated with 12.7 micrometers (0.5 mil) atomic oxygen-resistant conductive polymer composed of a mixture of COR and PANi, wrapped around a braided Kevlar 29 core. Extensive testing has been performed at the Marshall Space Flight Center to qualify this material for flight on ProSEDS. Atomic oxygen exposure has been performed, with solar absorptance and infrared emittance measured before and after exposure. Plasma chamber tests have been completed, as well as tether deployment tests. Also developed for the ProSEDS mission was the insulating polymer TOR-BP. Approximately 200 meters of the conductive tether closest to the Delta II second stage is insulated to prevent any electron reconnection to the tether from the plasma contactor. The insulating material is TOR-BP with a dielectric strength of TBD.
Blueprint: Cyberinfrastructure Center of Excellence (2021)

In 2018, NSF funded an effort to pilot a Cyberinfrastructure Center of Excellence (CI CoE or Center) that would serve the cyberinfrastructure (CI) needs of the NSF Major Facilities (MFs) and large projects with advanced CI architectures. The goal of the CI CoE Pilot project (Pilot) effort was to develop a model and a blueprint for such a CoE by engaging with the MFs, understanding their CI needs, understanding the contributions the MFs are making to the CI community, and exploring opportunities for building a broader CI community. This document summarizes the results of community engagements conducted during the first two years of the project and describes the identified CI needs of the MFs. To better understand MFs' CI, the Pilot has developed and validated a model of the MF data lifecycle that follows the data generation and management within a facility and gained an understanding of how this model captures the fundamental stages that the facilities' data passes through from the scientific instruments to the principal investigators and their teams, to the broader collaborations and the public. The Pilot also aimed to understand what CI workforce development challenges the MFs face while designing, constructing, and operating their CI and what solutions they are exploring and adopting within their projects. Based on the needs of the MFs in the data lifecycle and workforce development areas, this document outlines a blueprint for a CI CoE that will learn about and share the CI solutions designed, developed, and/or adopted by the MFs, provide expertise to the largest NSF projects with advanced and complex CI architectures, and foster a community of CI practitioners and researchers.
Computing minimum-phase factors of polynomials (2006)

The problem of finding the minimum-phase spectral factor of a polynomial is considered. A numerical algorithm is proposed, based on the least squares inverse and approximate polynomial greatest common divisor procedures, which solves the problem in an efficient way. Examples are provided.
Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s. (1990)

ras p21 GTPase-activating protein (GAP) has been proposed to interact with the putative effector domain of ras p21s, and smg p21, a ras p21-like guanine nucleotide binding protein (G protein), has been shown to have the same amino acid sequence as ras p21s in this region. In the present studies, we examined the effects of ras p21 GAP on the GTPase activity of smg p21 purified from human platelets, of smg p21 on the ras p21 GAP-stimulated GTPase activity of c-Ha-ras p21 purified from Escherichia coli, and of c-Ha-ras p21 on the smg p21 GAP1- or -2-stimulated GTPase activity of smg p21. ras p21 GAP stimulated the GTPase activity of c-Ha-ras p21 but not that of smg p21. The GTP-bound form of smg p21, however, inhibited the ras p21 GAP-stimulated GTPase activity of c-Ha-ras p21 in a dose-dependent manner. The half-maximum inhibition by smg p21 was obtained at 0.4 microM which was more potent than previously observed for ras p21 (2-200 microM). The GDP-bound form also inhibited the ras p21 GAP-stimulated GTPase activity of c-Ha-ras p21, but the efficiency was 40-50% that of the GTP-bound form. smg p21 GAP1 and -2 stimulated the GTPase activity of smg p21 but not that of c-Ha-ras p21. c-Ha-ras p21 did not inhibit the smg p21 GAP1- or -2-stimulated GTPase activity of smg p21. These results indicate that ras p21 GAP interacts with smg p21 without the subsequent stimulation of its GTPase activity.
Influence of the vagus nerve on release and action of secretin in dog. (1979)

1. The role of cholinergic nerve on plasma concentration of immunoreactive secretin and pancreatic bicarbonate secretion was investigated in conscious and anaesthetized dogs. 2. In conscious dogs with gastric and pancreatic fistulae, I.V. administration of 2-deoxy-D-glucose (2-DG) potentiated the pancreatic bicarbonate secretion stimulated by duodenal acidification. 3. In conscious dogs with same preparation, I.V. administration of atropine inhibited the pancreatic bicarbonate secretions stimulated by duodenal acidification or exogenous secretin. 4. Neither 2-DG nor atropine had any effect on endogenous release of secretin. 5. In anaesthetized dogs, pancreatic bicarbonate secretion stimulated by duodenal acidification was decreased by bilateral cervical vagotomy. However, plasma secretion concentration achieved by duodenal acidification was not different from that of pre-vagotomy state. 6. The data indicate that the changes of cholinergic tone do not affect release of endogenous secretin but alter the exocrine pancreatic bicarbonate secretion stimulated by secretin.
Pharmacology of Anti-CD3 Diphtheria Immunotoxin in CD3 Positive T-Cell Lymphoma Trials (2010)

Anti-CD3 recombinant diphtheria immunotoxin, A-dmDT(390)-bisFv(UCHT1), consists of the catalytic and translocation domains of diphtheria toxin fused to two single chain Fv fragments of an anti-CD3epsilon monoclonal antibody (UCHT1). A-dmDT(390)-bisFv(UCHT1) is capable of killing CD3(+) T-lymphoma cells and normal T cells specifically in the femtomolar concentration range. To study pharmacology of A-dmDT(390)-bisFv(UCHT1) in patients with CD3(+) T-cell lymphoma in a phase I clinical trial, (1) highly sensitive bioassay using Jurkat cells for measuring drug levels, (2) ELISA for measuring anti-DT antibody titer, and (3) 5-color FACS analysis method for measuring changes of subtype T-cell population were developed. In addition to evaluating drug efficacy and pharmacokinetics in patients, it is important to correlate pre-existing anti-DT antibody levels with maximum drug concentration in serum and extent of T-cell depletion because pre-existing anti-DT antibodies due to DPT (Diphtheria, Pertussis, and Tetanus) immunization can neutralize diphtheria immunotoxin. We observed that at the lowest treatment dose (2.5 microg/kg: twice daily for 4 days) A-dmDT(390)-bisFv(UCHT1) depletes greater than 99.0% of normal T cells in all six patients for a short period of time (2-3 days) and that there is no association of C (max) and extent of T-cell depletion with the pre-existing anti-DT antibody titer.
High resolution neutron imaging of water in PEM fuel cells (2008)

Optimal water management in Polymer Electrolyte Membrane (PEM) fuel cells is critical to improving the performance and durability of fuel cell systems especially during transient, start-up and shut-down operations. For example, while a high water content is desirable for improved membrane and catalyst ionomer conductivity, high water content can also block gas access to the triple-phase boundary resulting in lowered performance due to catalyst and gas diffusion layer (GDL) flooding. Visualizing liquid water by neutron imaging has been used over the past decade to study the water distribution inside operating fuel cells. In this paper, the results from our imaging at NIST using their recently installed higher resolution ({approx} 25 mm) Microchannel Plate (MCP) detector with a pixel pitch of 14.7 mm are presented. This detector is capable of quantitatively imaging the water inside the MEA (Membrane Electrode Assembly)/GDL (Gas Diffusion Layer) of working fuel cells and can provide the water profiles within these various components in addition to the channel water. Specially designed fuel cells (active area = 2.25 cm{sup 2}) have been used in order to take advantage of the full detector resolution. The cell design is illustrated in a figure where one of the current collector/end plates is shown. The serpentine pattern was machined into a block of aluminum and plated with nickel and then gold to form the flow field. The measurements were performed using beam no. 1 and aperture no. 2 with a fluence rate of 1.9 x 10{sup 6} neutrons cm{sup -2} sec{sup -1}. The cells were assembled with Gore{sup TM} Primea{sup R} MEAs and SGL Sigracet {sup R} 24 series GDLs (PRIMEA, GORE-SELECT and GORE are trademarks of W. L. Gore & Associates, Inc). All the cells were tested at 80 {sup o}C with 1.2 stoichiometry H{sub 2} and 2.0 stoichiometry air flows.
Long‐Term Surveillance of Treated Hyperparathyroidism for Multiple Endocrine Neoplasia Type 1: Recurrence or Hypoparathyroidism? (2015)

LSPX is highly associated with recurrence and TPX with continuous hypoparathyroidism, also after long-term follow-up. SPX should be the chosen method in the majority of patients with MEN1 HPT.
A Compact High Resolution Projector Utilizing A Laser-Diode Addressed Liquid Crystal Light Valve (1987)

A compact, high resolution, large screen projector,which can project a B4 size image at maximum 3000 x 3000 pixel resolution onto a maximum 2 meter square screen, has been developed. This projector size is compact and has low power consumption in comparison with the former projector using a gas laser, for example, an Argon laser, a big Xenon lamp with high power consumption and the liquid crystal light valve (LCLV) with complex thermal control mechanism. The projector measures 430 mm (W) x 365 mm (H) x 595 mm (D) and has less than 1kW (100 VAC,10 A) power consumption, using high power laser-diodes, a compact Xenon lamp (300 W) and the LCLVs installed in a compact cassette holder with thermal control mechanism. Furthermore, the projector can project a controllable cursor image, overlapping a B4 size document image, onto the screen, using two LCLVs projection and laser beam path changed by a moving mirror.
Augmenting paper to enhance community information sharing (2000)

Paper is traditionally considered as a major gap between the physical and electronic worlds, especially after the many attempts that have failed to attain a completely digital world. Paper based artifacts have many affordances that people want to continue to exploit.
Selectivity of Liquid Membrane Cadmium Microelectrodes Based on the IonophoreN,N,N′,N′-Tetrabutyl-3,6-dioxaoctanedithioamide (1998)

The selectivity of heavy metal ion-selective electrodes has often been inadequately characterized in the past. Only recently, alternative methods have become available to assess the response toward highly discriminated ion solutions. In this article, the selectivity of vibrating liquid membrane cadmium-selective microelectrodes was characterized using the separate solution method, the fixed interference method, the matched potential method, and Bakker's method which demands one to condition the electrode membrane in discriminated ion solutions prior to measurement. In this study, the matched potential method gave selectivity values for the two least discriminated ions, lead(II) and copper(II), that were comparable to the ones obtained with SSM. Bakker's method, on the other hand, was the only method that reveals the extremely high ion selectivity over all other discriminated ions. This study shows that carrier-based cadmium microelectrodes possess sufficient selectivity for many in situ applications, and that experimental biases may sometimes lead to experimental selectivity coefficient variations of about 12 orders of magnitude depending on the chosen method.
Pretrauma Cognitive Ability and Risk for Posttraumatic Stress Disorder (2007)

Preexposure cognitive ability is a risk or a protective factor for PTSD. The variance in PTSD explained by preexposure cognitive ability is accounted for entirely by common genetic factors. Lower cognitive ability may be a marker of less adaptive coping against adverse mental health consequences of exposure to potentially traumatic events. Further study of the potential mechanisms through which cognitive ability confers risk is needed.
Diamondlike carbon film deposition using a reactive pulsed electromagnetic inductive plasma process (1989)

A reactive pulsed electromagnetic inductive plasma process has been developed and used to deposit amorphous carbon films in methane discharges. The plasma state was investigated by analyzing spectral intensity emitted from H atoms and molecular fragments CH, which were produced by methane dissociation. The films deposited with this technique have outstanding characteristics due to the magnetohydrodynamic effect, good adhesion to room-temperature substrates, wide optical gap, highly insulating, and diamondlike structure. The film properties are correlated with excitation temperature and intensity ratio between specified spectral lines. Furthermore, it is shown that a pulsed plasma process combined with an rf glow discharge deposits amorphous carbon films that contain crystalline particles.
Silicon field emitter cathodes: Fabrication, performance, and applications (1998)

This article gives an overview of fabrication and performance of a class of vacuum microelectronic devices, namely, silicon tip-on-post field emitter arrays (FEAs). Experimental data illustrating the device performance are presented in the context of requirements for field emission flat panel display and microwave power amplifier applications. Critical geometrical parameters of the device are discussed, and a fabrication process flow designed to optimize these parameters is described. Equipment and methods for testing electrical performance of the FEAs and results thus generated are presented. Specifically, emission current versus gate voltage characteristics for arrays with tips formed using anisotropic (crystallographic–orientation–dependent) or isotropic etching techniques, uniformity of these characteristics across a 4 in. diameter substrate, stability of emission current in ultrahigh vacuum conditions, and changes in emission current upon exposure to active gases at varying pressure are discussed.
The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC): An ASC-IAC-Sponsored System for Reporting Salivary Gland Fine-Needle Aspiration (2018)

The diagnostic role of salivary gland fine-needle aspiration (SG-FNA) is well established in the preoperative evaluation of patients with salivary gland lesions. At present, most salivary SG-FNA specimens are diagnosed based on conventional diagnostic criteria. However, there exists a lack of uniform reporting for these specimens to guide the clinical management of patients. This void motivated a group of experienced cytopathologists to spearhead the development of a uniform reporting system. This international panel, under the sponsorship of the American Society of Cytopathology (ASC) and the International Academy of Cytology (IAC), gathered in September 2015 at the European Congress of Cytology, held in Milan, Italy, to propose the “Milan System for Reporting Salivary Gland Cytopathology” (MSRSGC). This effort sparked the interest of many and brought forth an agreement to develop an evidence-based tiered classification consisting of 6 diagnostic categories. It is hoped that this standard reporting system will enhance the overall effectiveness of SG-FNA reporting across institutions, with the ultimate result being better communication and improved patient care.
An electronically adjustable bandpass filter (2003)

An electronically adjustable bandpass filter based on the state-variable configuration is developed such that independent control of center frequency, quality factor, and gain is achieved. Electronic tuning of these parameters is accomplished with operational transconductance amplifiers is subcircuits which simulate floating resistors. Linearity of center frequency versus control input and relative independence are demonstrated for a wide input dynamic range.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A power-saving modulation technique for time-of-flight range imaging sensors (2011)

Time-of-flight range imaging cameras measure distance and intensity simultaneously for every pixel in an image. With the continued advancement of the technology, a wide variety of new depth sensing applications are emerging; however a number of these potential applications have stringent electrical power constraints that are difficult to meet with the current state-of-the-art systems. Sensor gain modulation contributes a significant proportion of the total image sensor power consumption, and as higher spatial resolution range image sensors operating at higher modulation frequencies (to achieve better measurement precision) are developed, this proportion is likely to increase. The authors have developed a new sensor modulation technique using resonant circuit concepts that is more power efficient than the standard mode of operation. With a proof of principle system, a 93-96% reduction in modulation drive power was demonstrated across a range of modulation frequencies from 1-11 MHz. Finally, an evaluation of the range imaging performance revealed an improvement in measurement linearity in the resonant configuration due primarily to the more sinusoidal shape of the resonant electrical waveforms, while the average precision values were comparable between the standard and resonant operating modes.