gebhart/patrepeval huggingface dataset:
위구르 시인 페르핫 투르순 시의 궤적 ―디스토피아와 대면하는 인문적 지성의 고통 (2020)

With his wife and children, Uyghur poet Perhat Tursun had been dwelling in the old urban center populated by Uyghur people in the southern part of Urumqi, the capital city of Xinjiang, until he was arrested in early 2018 and imprisoned in the so-called Re-education Center. In early 2020, it was reported that he was sentenced to sixteen years imprisonment, the procedure of which has not been made public. This paper will explore the forest of metaphors implanted onto the field of his elaborate poems by Perhat Tursun through the early 21st century, which embodies the ominous signals bearing the vision of distopia initiating the dismantle of Uyghur society. It will put focus on how the poet, who left Islamic belief out for the ocean of humanities during the Springtime in Beijing in late 1980’s, has endeavoured to face the distopia. In the first decade of 21st century under the flag of Great Western Development Program, Perhat Tursun has struggled to keep staring at the dark abyss of distopia with his own human intellectual effort, however, in the second decade, his defiant intellect eventually gives way to the whirlwind entailed by the Urumqi Riot in the summer of 2009. Special concern will be brought on this pathway to his intellectual collapse, which reveals the exhaustion of his capability of resistance against the harsh burden of state violence added to the age-old constraints of Uyghur society.
The use of physical hydrogels of chitosan for skin regeneration following third-degree burns (2007)

International audience
Optical self-injection stabilization of a passively mode-locked quantum dot on silicon laser (2020)

Passively mode-locked InAs/InGaAs quantum dot on silicon lasers emitting at 1310nm are promising sources for high-speed high-capacity communication applications. Optical self-injection stabilization of a monolithic passively mode-locked quantum dot on Silicon laser with an absorber section length to total length ratio of 18% is investigated experimentally. A repetition rate tuning range of 24MHz around the free-running repetition rate of 9.4 GHz and a pulse-to-pulse timing jitter reduction by a factor of 2.5 from 150 fs to 59 fs are achieved for an external optical cavity length of 5.8m with fine-delay control. Obtained experimental results are in good quantitative agreement with simulation results obtained by a stochastic time-domain model.
Iloprost modulates the immune response in systemic sclerosis (2010)

These results suggest that iloprost has anti-inflammatory and immunomodulating effects, reducing TNF alpha production by T cells and the number of T regulatory cells and increasing IL-2 and RANKL.
Coordination of Eye and Head Movements during Reading (2003)

Head movement strategies are rapidly switched between the A4 and 90 degrees text-reading paradigms. They are minimized during A4 text reading but actively assist the gaze strategy during 90 degrees text reading. Horizontal head movement is reduced during A4 reading compared to the equivalent saccadic task and may be suppressed to improve fixation stability. The results support the view that the head and eye movement system is a highly coupled but extremely flexible system.
A detailed simulation of a ‘closed loop’ multi function radar (1998)

A `closed loop' simulation of the BAeDS family of multi function radars has been developed by the Radar Systems group at Cowes. The closed loop nature of a MFR, where the next task executed by the radar depends on the results of previously executed tasks, causes the performance of the radar to be dominated by the effects of positive and negative feedback. Many of the resulting effects can, in practice, be studied only with the aid of a detailed simulation which models all the major parts of the system, including the environment. The model reported here consists of a number of `plug in' sub systems designed to be easily replaced with similar units. This enables different systems to be modelled by changing only the detail of each sub system. The model has proved its worth by demonstrating unexpected behaviour due to feedback. The initial use of the model demonstrated that unforeseen feedback loops, involving the track extractor, rendered the original energy partitioning between surveillance and track initiation, derived on the basis of an open loop model, less than optimal. (7 pages)
Structure and stability of discrete breather in zigzag and armchair carbon nanotubes (2016)

Structure and stability of stationary discrete breathers (DBs) in armchair and zigzag carbon nanotubes (CNTs) are investigated numerically. Precise numerical solutions of DB in CNTs are calculated by a numerical method that couples the Newton-Raphson method and molecular dynamics method. Linear stability analysis is performed by constructing of monodromy matrix of the numerical solution of DB from the numerical results of MD simulation. In both structures of zigzag and armchair carbon nanotube, stationary DBs with higher angular frequency above zone boundary mode exist. Displacement of DB is on cylindrical plane of CNTs. Linear stability analysis shows that DBs in both armchair CNT and zigzag CNT are unstable. The maximum growth rate of the unstable perturbation mode can be calculated numerically. The maximum growth rate of armchair CNT is greater than that of zigzag CNT even when the curvature of the cylindrical plane of zigzag CNT is greater than armchair CNT. In both case of armchair and zigzag CNT, the unstable motion is excited in the direction out of the cylindrical plane of CNTs. Unstable dynamics is suppressed by introducing extensive strain in axial direction of CNT. In this case, motion of the unstable perturbation modes is confined on the cylindrical plane of CNTs
My first and my latest publication (2022)

Abstract The author discusses the lessons he has learned in the process of performing the research that led to his first publication on the photochemistry of β , γ ‐unsaturated ketones in 1970 and to his latest publication on the history of the Woodward–Hoffmann rules in 2022.
4-ary Odor-Shift Keying Using Multi-channel Olfactory Display (2019)

Odor-shift keying, a data modulation technique that encodes digital data by varying odor presentation, was proposed in this paper. A multi-channel olfactory display was used as modulator to release multiple odors whose blending ratio representing different digital data. On the demodulator side, an odor sensing system is used to measure the released smells, revert them into electrical form which is then decoded into the original data by using digital signal processing. The proposed technique can enhance data transfer rate of the communication through odor as carrier. A preliminary experiment was conducted to validate the possibility of the concept of varying the presented odors to represent different binary data. Finally, a string was practically modulated and transmitted by using the proposed technique. The demodulation process can be performed successfully and the data transfer rate was doubled from the previous work.
Femtosecond Laser Photodisruption of the Crystalline Lens for Restoring Accommodation (2011)

International Ophthalmology Clinics: Spring 2011 - Volume 51 - Issue 2 - p 87-95 doi: 10.1097/IIO.0b013e31820f8844
Dynamic Compressive Sensing of Time-Varying Signals Via Approximate Message Passing (2013)

In this work the dynamic compressive sensing (CS) problem of recovering sparse, correlated, time-varying signals from sub-Nyquist, non-adaptive, linear measurements is explored from a Bayesian perspective. While there has been a handful of previously proposed Bayesian dynamic CS algorithms in the literature, the ability to perform inference on high-dimensional problems in a computationally efficient manner remains elusive. In response, we propose a probabilistic dynamic CS signal model that captures both amplitude and support correlation structure, and describe an approximate message passing algorithm that performs soft signal estimation and support detection with a computational complexity that is linear in all problem dimensions. The algorithm, DCS-AMP, can perform either causal filtering or non-causal smoothing, and is capable of learning model parameters adaptively from the data through an expectation-maximization learning procedure. We provide numerical evidence that DCS-AMP performs within 3 dB of oracle bounds on synthetic data under a variety of operating conditions. We further describe the result of applying DCS-AMP to two real dynamic CS datasets, as well as a frequency estimation task, to bolster our claim that DCS-AMP is capable of offering state-of-the-art performance and speed on real-world high-dimensional problems.
Application of Nitrile in Drug Design (2012)

Nitrile-containing compounds comprise a substantial proportion in the therapeutic drugs.It is an important strategy to introduce nitrile substitute in the small molecule for structure-based medicinal chemistry.The application of nitrile in drug design is reviewed.The nitrile can modulate the physicochemical and pharmacokinetic properties to improve bioavailability, enhance the selectivities and binding affinity to target proteins by hydrogen bond interactions, covalent interactions, polar interactions, and π-π interactions.Meanwhile, the nitrile acts as bioisostere of various functional groups such as carbonyl and halogen groups.In addition, introducing the nitrile to drug molecules can block metabolically labile sites to increase the metabolic stability of drugs.
Do Free-Living Amoebae in Treated Drinking Water Systems Present an Emerging Health Risk? (2010)

There is an expanding body of evidence that free-living amoebae (FLA) increase both the numbers and virulence of water-based, human-pathogenic, amoeba-resisting microorganisms (ARM). Legionella spp., Mycobacterium spp., and other opportunistic human pathogens are known to be both ARM and also the etiologic agents of potentially fatal human lung infections. However, comparatively little is known about the FLA that may facilitate ARM growth in drinking water. This review examines the available literature on FLA in treated drinking water systems; in total 26 studies from 18 different countries. FLA were reported to breakthrough the water treatment barrier and enter distribution systems, in addition to the expected post-treatment system ingress. Once in the distribution system there is evidence of FLA colonization and regrowth especially in reservoirs and in-premise plumbing storage tanks. At the point of use the average FLA detection rate was 45% but highly variable (n = 16, σ = 31) due to both differences in both assay methods and the type of water systems examined. This review reveals that FLA are consistently detected in treated drinking water systems around the world and present a yet unquantified emerging health risk. However, more research is urgently required before accurate risks assessments can be undertaken to assess the impacts on human health, in households and institutions, due to exposure to FLA facilitated pathogenic ARM.
Toxicity-Free Hematopoietic Stem Cell Engraftment Achieved with Anti-CD117 Monoclonal Antibody Conditioning (2019)

Successful hematopoietic cell transplantation (HCT) requires vacating recipient hematopoietic stem cell (HSC) niches to permit donor HSC engraftment to provide life-long hematopoietic and immune function. Currently HCT relies on DNA damaging radiation or chemotherapy to achieve HSC niche clearance. We have pursued a non-toxic approach to target and deplete HSC using humanized monoclonal antibody, AMG 191, that binds human CD117 (c-Kit). We opened a Phase 1 dose escalation trial using AMG 191 as the sole conditioning agent to achieve donor HSC engraftment in patients undergoing HCT for severe combined immunodeficiency (SCID).The primary endpoint is to assess the safety of administering AMG 191. Secondary endpoints include AMG 191 pharmacokinetics (PK), host HSC depletion, and determination of the dose of AMG 191 that achieves adequate donor HSC engraftment, defined as >5% donor granulocyte chimerism at 24 weeks. We have completed the first dose cohort of patients receiving 0.1 mg/kg AMG 191 and treated the first two patients in the second cohort (0.3 mg/kg). All five patients tolerated the AMG 191 infusion and the subsequent infusion of their CD34-selectd donor cells without clinical problems. Here we report efficacy in the first two patients, who have reached the 24-week timepoint. Both patients had T-B-NK+ SCID with mutations in the DCLRE1C (Artemis) gene. Both previously received unconditioned HCT as infants, failed to develop donor B cells and remained dependent on exogenous immunoglobulin. CD34-selected mobilized peripheral blood cells from the original donors were infused when the AMG 191 serum level was <100 ng/mL. Beginning at 8 weeks post-HCT both patients showed evidence of increasing peripheral blood CD19+CD20+ B cells. Extended immunophenotype analysis demonstrated that naïve B cells were present, and chimerism studies confirmed that the B cells were of donor origin. The first patient had impaired T cell function prior to his HCT. Significant increases in both naïve CD4+ and CD8+ T cells were observed with clinical improvement beginning at 22 weeks post-HCT. Importantly, starting at 8 weeks these 2 patients demonstrated donor chimerism in purified granulocytes, an indicator of HSC engraftment, which rose from 0% pre-HCT to ≥5% at 24 weeks (Table 1).Conclusion: These data are proof of concept that a humanized monoclonal antibody targeting CD117 can safely clear human HSC niches and facilitate donor HSC engraftment. This study is ongoing and open for enrollment.
First Phenylene Polymers Linked by Sulfonium Groups (1996)

Alternating phenylene units and methylsulfonium groups make up polymer 1, which is formed by polymerizing benzene with sodium methanesulfinate. This reaction is conducted in trifluoromethane-sulfonate, and xylene and diphenyl ether are also suitable monomers.
Environmental and Hormonal Control of Turion Germination in Myriophyllum verticillatum (1976)

Germination, or outgrowth, of Myriophyllum verticillatum turions involves a series of visible changes starting with reflexing of leaves followed by extension and curving of the axis, and then by root formation. Before abscission, turions grow out in response to long days (16 hr) but not short days (8 hr). After abscission, turions show maximal dormancy which can be fully broken by a cold treatment (4 C). Turions are heterogeneous in degree of dormancy and ability to respond to less complete dormancy-breaking treatments, e.g., long days at 20 C. Cytokinins (10-6 m) break dormancy of non-cold-treated turions, whereas gibberellic acid (GA3) is ineffective except at high concentrations (10-3 m). Continuous treatment with cytokinins causes abnormal development after germination. GA3, on the other hand, induces apparently normal development even at high concentration. Indoleacetic acid (IAA) induces outgrowth only at high concentrations (10-3 - 10-4 m), but these concentrations also produce abnormal development. Abscisic acid (ABA, 10-5 m) retards outgrowth of cold-treated turions and can completely suppress it in non-cold-treated turions. The activity of ABA-like substances in turions remains about the same before and during germination, whereas other (unidentified) acidic inhibitors decrease markedly. The cytokinin activity changes in a complex pattern.
Involvement of ADP-ribosylation Factor 1 in Cholera Toxin-induced Morphological Changes of Chinese Hamster Ovary Cells (2001)

ADP-ribosylation factor 1 (ARF1) was originally found as a cofactor in CT-catalyzed ADP-ribosylation of Galpha(s) but is now known to participate in vesicle trafficking. We asked whether ARF1 function in vesicular trafficking is necessary for CT-induced morphological changes in Chinese hamster ovary (CHO) cells, which result from increased intracellular cAMP. Brefeldin A treatment of cells suppressed CT action, confirming a requirement for Golgi integrity. Overexpression of a GFP-ARF1 fusion protein did not affect the morphological changes induced by CT, but changes were reduced in cells overexpressing guanine nucleotide exchange-defective ARF1(T31N) or GTP hydrolysis-deficient ARF1(Q71L) mutants. In cells expressing these mutants, 8-bromo-cAMP induced changes similar to those seen in cells transfected with ARF1 or vector. Inhibition of CT action was specific for mutants of ARF1 and not reproduced by analogous mutants of ARF5 or ARF6. ARF1(Q71L) was mostly colocalized with betaCOP, but ARF5(Q71L) less so. ARF6(Q67L) did not colocalize with betaCOP and was partially associated with the plasma membrane. These data are consistent with the conclusion that ARF1 influenced CT action in cells by its specific function in the vesicular transport pathway used by CT to travel from plasma membrane to Golgi to ER.
Use of Artificial Neural Networks to Investigate the Surface Roughness in CNC Milling Machine (2014)

In order to sustain in the global market competitiveness, maintaining the quality of the component plays a key role to satisfy the customer requirements. Quality can be determined by its surface roughness or by its surface finish. In this work, optimization of machine tool parameters is carried out for CNC milling machine. Machine tools can be used effectively by considering the optimal cutting parameters like speed, feed, and depth of cut. However these parameters greatly influence on the material removal rate and surface finish. This paper aims to investigate the surface roughness values at various speeds, feed and depth of cut conditions by using Artificial Neural Networks. ANN results show that there is no significant difference between the experimental values and predicted roughness values. From these results, conclude that the ANN is best suitable and accurate for solving the cutting parameter optimization.
A Model for Personalized in Vivo Analysis of Human Immune Responsiveness (2012)

Studies of human immune diseases are generally limited to the analysis of peripheral blood lymphocytes of heterogeneous patient populations. Improved models are needed to allow analysis of fundamental immunologic abnormalities predisposing to disease and in which to assess immunotherapies. Immunodeficient mice receiving human fetal thymus grafts and fetal CD34(+) cells intravenously produce robust human immune systems, allowing analysis of human T cell development and function. However, to use humanized mice to study human immune-mediated disorders, immune systems must be generated from adult hematopoietic cells. Here, we demonstrated robust immune reconstitution in mice with hematopoietic stem cells (HSCs) aspirated from bone marrow of adults with type 1 diabetes (T1D) and healthy control volunteers. In these humanized mice, cryopreservation of human leukocyte antigen allele-matched fetal thymic tissue prevented allogeneic adult HSC rejection. Newly generated T cells, which included regulatory T cells (T(regs)), were functional and self-tolerant and had a diverse repertoire. The immune recognition of these mice mimicked that of the adult CD34(+) cell donor, but the T cell phenotypes were more predominantly "naïve" than those of the adult donors. HSCs from T1D and control donors generated similar numbers of natural T(regs) intrathymically; however, peripheral T cells from T1D subjects showed increased proportions of activated or memory cells compared to controls, suggesting possible HSC-intrinsic differences in T cell homeostasis that might underlie immune pathology in T1D. This "personalized immune" mouse provides a new model for individualized analysis of human immune responses that may provide new insights into not only T1D but also other forms of immune function and dysfunction as well.
The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase (2017)

Following the in vivo investigation of thiotetronate assembly in Lentzea sp. and in S. thiolactonus NRRL 15439 (Havemann et al., Chem. Commun., 2017, DOI: 10.1039/c6cc09933e), the minimal set of genes required for thiolactomycin production was determined through heterologous expression and the mechanism for polyketide assembly was established in vitro through incubation of recombinant TlmB with its substrates in the presence of either nonhydrolysable or hydrolysable chemical probes. The results presented here constitute unequivocal evidence of enzymatic processing by an unusual iterative polyketide synthase.
Evaluation of the Adequacy between the Workload and the Number of State Midwives and Maieuticians Practicing in the Gynecology-Obstetrics Departments of the University Hospitals of Burkina Faso (2022)

Objective: To evaluate the adequacy between the workload and the number of midwives and state midwives practicing in the gynecology-obstetrics services of the university hospitals of Burkina Faso. Methodology: This is a multicenter study conducted in 4 university hospitals representing this country (for brevity referred here to as A, B, C, and D) from May 1, 2018, to April 30, 2019. The Workload Indicators of Staffing Need (WISN) method was used to analyze the workload. Results: Dystocic delivery was the activity that took the most time. Inpatient activities were the most performed in terms of volume. At the University Hospitals D and C, there was an over-staffing of midwives and maïeuticians with a ratio of 1.93 and 2.12 respectively. At University Hospital B, the workload was in line with the existing number of State midwives and maieuticians. A low workload pressure (04%) was found at the University Hospital A. Conclusion: In most of the University Hospital Centers, there was no match between the workload and the number of midwives and maïeuticians. These results highlight the need for redeplayment of midwives and maïeuticians in order to ensure good health coverage for midwives and maïeuticians.
Unusual C-6 Lithiation of 2-Chloropyridine-Mediated by BuLi−Me2N(CH2)2OLi. New Access to 6-Functional-2-chloropyridines and Chloro-bis-heterocycles (2000)

The reaction of 2-chloropyridine with alkylithium generally results in nucleophilic addition leading to the loss of chlorine atom while exclusive directed ortho metalation is obtained using LDA. Herein it is shown that the BuLi-Me(2)N(CH(2))(2)OLi (BuLi-LiDMAE) superbase promotes an unprecedented regioselective C-6 lithiation. The method was successfully applied to the preparation of potentially useful chlorinated pyridinic and bis-heterocyclic synthons.
A VLIW Vector Media Coprocessor With Cascaded SIMD ALUs (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> High-definition video applications, such as digital TV and digital video cameras, require high processing performance for high-quality visual images in addition to a complex video CODEC. Pre-/postprocessing to improve video quality is becoming much more important because requirements for pre-/postprocessing vary among applications and processing algorithms have not been stabilized. Therefore, a new processor architecture that has a highly parallel datapath is needed. In this paper, we introduce a VLIW vector media coprocessor, “vector coprocessor (VCP),” that includes three asymmetric execution pipelines with cascaded SIMD ALUs. To improve performance efficiency, we reduce the area ratio of the control circuit while increasing the ratio of the arithmetic circuit. The total gate count of VCP is 1268 kgates and its maximum operating frequency is 300 MHz at 90-nm CMOS process. Some of the processing kernels in an adaptive prefilter that is applied to preprocessing for video encoding are evaluated. In the case of the edgeness and the sum of absolute differences, the performance is 183 giga operations per second. VCP offers enough performance for HD video processing and good cost-performance while all processing pipeline units operate effectively. </para>