gebhart/patrepeval huggingface dataset:
Estimation of effective dose equivalent to staff in diagnostic radiology (1988)

The irradiation of staff in diagnostic radiology was simulated for conditions commonly encountered in fluoroscopy. Scattered radiation distributions were produced from diagnostic x-ray beams generated at tube potentials in the range 60-120 kVp, using the abdomen sections of a Rando phantom. Doses to a number of organs in the head and neck were measured using a Rando phantom loaded with lithium fluoride thermoluminescent dosemeters. The torso sections were placed on a water phantom on top of a stand, with film badge dosemeters positioned on the surface of the phantom at the forehead, neck, chest and waist, and the phantom was placed in the radiation field. Doses to organs in the torso were calculated from the waist-level film badge dosemeter reading using normalised organ dose data. Radiation doses to organs below a lead apron, when worn, were estimated from the unshielded dose values using a transmission factor appropriate to the quality of the scattered radiation. The effective dose equivalent (EDE) to the phantom was calculated for various x-ray beam qualities and lead apron thicknesses and compared with the film badge doses. The results indicate that a dosemeter worn at the waist/chest level under a lead apron generally underestimates the EDE. Conversely, dosemeters worn at the forehead/neck tend to overestimate the EDE. It is recommended that a dosemeter is positioned under a lead apron, if worn.
Ventriculoperitoneal shunt in patients with leptomeningeal metastasis (2005)

The authors reviewed 37 patients with leptomeningeal metastasis (LM) who required a ventriculoperitoneal shunt (VP shunt) for management of intracranial hypertension. Improvement was seen in 27 (77%) patients; subdural hematoma developed in one and shunt malfunction in three. Median overall survival was 2 months (range 2 days to 3.6 years) after VP shunt placement, but there was no procedure-related mortality. The prognosis of LM remained poor, but VP shunt can be an effective palliative tool when required.
Tissue factor in cultured cells: metabolic control. (1976)

Tissue factor content of WISH amnion cells in spinner culture increases 3- to 10-fold within 12 hours after subculture, then declines to a basal level within 30 to 50 hours. Maximal development of activity requires fresh serum and fresh medium. When added at the time of subculture, actinomycin D and cycloheximide completely inhibit development of coagulant activity; when added several hours after transfer, these inhibitors suppress the development but do not affect the disappearance of activity. Of the oxidative phosphorylation inhibitors tested, dinitrophenol had no effect whereas carbonyl cyanide m-chlorophenylhydrazone inhibited the activity increase but did not alter the decline. The kinetics of development and decay are similar over a pH range of 6.7 to 7.6 and with fetal calf serum concentration between 5 and 30 per cent. At pH 6.7 or in 30 per cent fetal calf serum, cell division did not occur. 3H-leucine and 35SO4= incorporation into the cell surface coat did not change appreciably during the burst of coagulant activity nor did the levels of naphthylamidase or alkaline phosphatase; 3H-thymidine incorporation reached a peak within 2 hours of the tissue factor maximum.
Mining Data Streams: Systems and Algorithms (2012)

This chapter provides an overview of the key challenges in stream mining and describes stream mining systems, and algorithms designed to overcome these. It discusses the generic challenges that stream mining poses to a variety of data management and data mining problems. The chapter focuses on different algorithms for stream data reduction and stream mining. The key stream processing and mining challenges include stream data management, relational processing on streams, stream indexing, and stream mining. The problem of indexing data streams attempts to create an indexed representation, so that it is possible to efficiently answer different kinds of queries such as aggregation queries or trend-based queries. The types of analysis that need to be performed on streaming data can be arbitrarily complex and may include several sophisticated learning techniques. Stream processing systems are typically designed in the form of distributed systems that are designed to tackle the complex data management and processing issues associated with high-volume data streams.
Enhancing performance of HW/SW cosimulation and coemulation by reducing communication overhead (2006)

For system-level simulation of a complex system-on-chip design, multiple hardware simulators and emulators can be combined to work together. The simulation performance in this case is often limited by the communication overhead between simulators and emulators. To reduce the amount of communication in this heterogeneous simulation environment, we propose novel methods to find a time interval during which there are no transactions among simulators based on a dynamic prediction of transaction occurrence time for both software and hardware models. We also propose a simulator scheduling algorithm which allows the simulator to work alone without interaction with others when there is no transaction. By so doing, we reduced the amount of pure communication by a factor of 15 to 67 and, as a result, achieved a speed-up factor of 4 to 40 compared to existing lock-step simulation, as shown by experimental results with various application examples.
The Thermal Isomerization of Trifluoromethyl- and Trifluoroethylcyclopropane1 (1965)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTThe Thermal Isomerization of Trifluoromethyl- and Trifluoroethylcyclopropane1D. W. Placzek and B. S. RabinovitchCite this: J. Phys. Chem. 1965, 69, 7, 2141–2145Publication Date (Print):July 1, 1965Publication History Published online1 May 2002Published inissue 1 July 1965https://pubs.acs.org/doi/10.1021/j100891a001https://doi.org/10.1021/j100891a001research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Crony (1862)

Journal Article Crony Get access A. A. A. A. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s3-I, Issue 3, 18 January 1862, Pages 50-b–50, https://doi.org/10.1093/nq/s3-I.3.50b Published: 18 January 1862
Restricted diffusion and the return to the origin probability at intermediate and long times (1997)

Pulsed field gradient spin echo magnetic resonance measurements on fluid saturated porous media provide a natural framework for the examination of a classic problem in mathematical physics. We examine the overall time dependence of the return to the origin probability (RTOP) with particular emphasis on the intermediate and long time behavior. In the long time limit this probability is related to the electrical conductivity. In periodic geometries we compare the results of eigenvalue expansions and numerical simulations. Here we find that, when the diffusion length is roughly equal to a pore diameter, the normalized RTOP, ${\mathrm{P}}_{\mathrm{s}}$(t), shows a maximum. Thus, the approach to the long time limit is not monotonic. We show that the existence of this maximum can be predicted based on variational arguments. For disordered systems, simulations and experiments are found to be in agreement and again suggest that the behavoir of ${\mathrm{P}}_{\mathrm{s}}$(t) is not monotonic.
Early Estrogen Replacement Therapy Reverses the Rapid Loss of Trabecular Bone Volume and Prevents Further Deterioration of Connectivity in the Rat (1999)

To evaluate the ability of estrogen replacement therapy (ERT) to prevent changes in trabecular bone volume (BV/TV) and connectivity beginning either at ovariectomy (OVX) or 5-13 days after OVX in adult female rats, the right proximal tibial was examined by three-dimensional X-ray tomographic microscopy (XTM) in vivo. Animals had XTM scans of the right tibia and then were randomized into six groups (n = 9). Groups 2-6 had bilateral (OVX), while group 1 was sham-ovariectomized (OVXd) on day 0. Animals were treated with vehicle (groups 1 and 2) or 17beta-estradiol therapy (ERT) at 10 microg/kg three times per week starting at days 0, 5, 8, and 13 post-OVX (groups 3, 4, 5, and 6), until day 50 when they were rescanned by XTM and sacrificed. Trabecular bone structural variables were calculated from XTM data (BV/TVx and beta1/BV/TVx) and standard histomorphometry. Trabecular bone volume (BV/TVx) and the trabecular connections per cubic millimeter of trabecular bone (beta1/BV/TVx) were maintained in both sham-OVXd animals and OVX animals given ERT from the time of OVX. However, OVX + vehicle-treated animals lost 54% BV/TVx and 46% beta1/BV/TVx (p < 0. 01 from day 0). BV/TVx and beta1/BV/TVx decreased rapidly post-OVX to -22% and -25% at day 13 (p < 0.01 from day 0). ERT initiated at day 5, 8, and 13 post-OVX restored BV/TVx to baseline values at day 50 by modestly increasing trabecular plate thickness; however, beta1/BV/TVx was reduced in all OVX groups when compared with their baseline values. ERT also caused a significant reduction in bone turnover compared with OVX + vehicle; however, resorption was suppressed more than formation. These results demonstrate that ERT can restore the lost trabecular bone, but not trabecular connectivity, that occurs soon after OVX by allowing bone formation to continue in previously activated bone remodeling units while suppressing the production of new remodeling units. This may be the mechanism by which prompt intervention with estrogen and other antiresorptive agents can restore bone mass that has been lost from the increase in remodeling space, and thereby reduce the risk of osteoporotic fractures in postmenopausal women.
Insulin-Like Growth Factor (IGF)-II Inhibition of Endometrial Stromal Cell Tissue Inhibitor of Metalloproteinase-3 and IGF-Binding Protein-1 Suggests Paracrine Interactions at the Decidua:Trophoblast Interface during Human Implantation1 (2001)

In human pregnancy, insulin-like growth factor (IGF)-II messenger RNA (mRNA) is expressed at the maternal-fetal interface exclusively by the placental trophoblast. Highest levels are expressed by the invading extravillous trophoblasts, which also secrete matrix metalloproteinases as they degrade the decidual extracellular matrix. In contrast, the maternal decidua expresses high levels of IGF-binding protein (IGFBP)-1 and tissue inhibitors of matrix metalloproteinase (TIMPs), both of which inhibit trophoblast invasiveness in vitro. The present study investigated the hypothesis that IGF-II may serve as a paracrine modulator of maternal restraints on invasion, by examining its effects on TIMP-3 and IGFBP-1 expression by decidualized endometrial stromal cells. Human endometrial stromal cells were decidualized in vitro with progesterone (P), after which 0-130 nM IGF-II and IGF analogs were added. IGFBP-1 in conditioned medium was assayed by immunoradiometric assay. In addition, Northern analyses were conducted using a PCR-generated 421-bp complementary DNA (cDNA) fragment corresponding to nucleotides 132-553 of the human TIMP-3 cDNA, and a 934-bp EcoRI fragment of the human IGFBP-1 cDNA. TIMP-3 mRNA transcripts of 2.2, 2.5, and 4.4 kilobases were detected in decidualized stromal cells not treated with IGF-II, but not detected in nondecidualized stromal cells, consistent with its known induction upon decidualization and in response to P. In decidualized stromal cells, IGF-II and Des(1-6) IGF-II, an analog with reduced affinity for IGFBPs, caused a dose-dependent inhibition of TIMP-3 mRNA expression. Long R(3) IGF-I, an IGF analog with minimal affinity for IGFBPs, also significantly inhibited (79 +/- 0.3%) TIMP-3 mRNA expression in these cells at 6 nM. Decidualized stromal cells secreted IGFBP-1 and expressed a 1.5-kilobase IGFBP-1 transcript, which was not detected in nondecidualized cells, consistent with its known induction upon decidualization and in response to P. IGF-II caused a dose-dependent inhibition of IGFBP-1 mRNA expression and protein secretion in decidualized stromal cells when added in molar excess of endogenous IGFBP-1 levels, with virtually complete inhibition at higher concentrations of IGF-II (65 and 130 nM). By comparison, Long R(3) IGF-I inhibited IGFBP-1 expression with a 50% effective dose of 0.2-0.4 nM. These data suggest that the invading trophoblast has the capacity, via IGF-II, to inhibit maternal restraints on trophoblast invasiveness by regulating decidual TIMP-3 and IGFBP-1.
Linearized dynamics equations for the balance and steer of a bicycle: a benchmark and review (2007)

We present canonical linearized equations of motion for the Whipple bicycle model consisting of four rigid laterally symmetric ideally hinged parts: two wheels, a frame and a front assembly. The wheels are also axisymmetric and make ideal knife-edge rolling point contact with the ground level. The mass distribution and geometry are otherwise arbitrary. This conservative non-holonomic system has a seven-dimensional accessible configuration space and three velocity degrees of freedom parametrized by rates of frame lean, steer angle and rear wheel rotation. We construct the terms in the governing equations methodically for easy implementation. The equations are suitable for e.g. the study of bicycle self-stability. We derived these equations by hand in two ways and also checked them against two nonlinear dynamics simulations. In the century-old literature, several sets of equations fully agree with those here and several do not. Two benchmarks provide test cases for checking alternative formulations of the equations of motion or alternative numerical solutions. Further, the results here can also serve as a check for general purpose dynamic programs. For the benchmark bicycles, we accurately calculate the eigenvalues (the roots of the characteristic equation) and the speeds at which bicycle lean and steer are self-stable, confirming the century-old result that this conservative system can have asymptotic stability.
Self-organisation through size-exclusion in soft materials (2015)

Can the interplay between steric and electronic properties induced by end-groups be used to dictate self-organisation in soft materials?
Clinical Experience with Upper Tract Urodynamics (1983)

Of 25 upper tract urodynamic studies performed in 22 patients 9 positive results were obtained. The diagnosis of intrinsic ureterovesical junction obstruction was suspected in 11 children but only confirmed in 2. However, in 6 other children changes in bladder volume markedly affected upper tract function. While diuretic renography may confirm obstruction in many doubtful cases, when function is poor and the system is dilated massively a urodynamic study often will be the only definitive diagnostic procedure.
DETECTING BAD DESIGN AND BIAS FROM PATENTS (2021)

Abstract The representation of the product use context is a well established design practice in Engineering Design. Recently, design theory is studying the product interaction involving several cognitive aspects such as the possible conditions in which a wrong interaction occurs. The aim of this paper is to find a quantitative evidence of the causes of these misuses. In particular, this study focuses on the detection of bad design and biases. In this paper, we propose a method that helps to the automatic detection of bad design and biases from patents. The method is based on an approach that defines syntactic rules to detect sentences containing these artifacts. These rules are defined based on an exploratory analysis of the explicit mention of “bad design” and “bias” and then, tested with multiple experiments on a sample of patents. The results give a first quantitative evidence of the presence of bad design and biases in patents and consequently of their importance in the design theory. In particular, it is provided a fine grain analysis of the linguistic structure of sentences containing these artifacts helping designers in detecting automatically them from patents.
Transplantation of Quail Collagen-tailed Acetylcholinesterase Molecules Onto the Frog Neuromuscular Synapse (1997)

The highly organized pattern of acetylcholinesterase (AChE) molecules attached to the basal lamina of the neuromuscular junction (NMJ) suggests the existence of specific binding sites for their precise localization. To test this hypothesis we immunoaffinity purified quail globular and collagen-tailed AChE forms and determined their ability to attach to frog NMJs which had been pretreated with high-salt detergent buffers. The NMJs were visualized by labeling acetylcholine receptors (AChRs) with TRITC-alpha-bungarotoxin and AChE by indirect immunofluorescence; there was excellent correspondence (>97%) between the distribution of frog AChRs and AChE. Binding of the exogenous quail AChE was determined using a species-specific monoclonal antibody. When frog neuromuscular junctions were incubated with the globular G4/G2 quail AChE forms, there was no detectable binding above background levels, whereas when similar preparations were incubated with the collagen-tailed A12 AChE form >80% of the frog synaptic sites were also immunolabeled for quail AChE attached. Binding of the A12 quail AChE was blocked by heparin, yet could not be removed with high salt buffer containing detergent once attached. Similar results were obtained using empty myofiber basal lamina sheaths produced by mechanical or freeze-thaw damage. These experiments show that specific binding sites exist for collagen-tailed AChE molecules on the synaptic basal lamina of the vertebrate NMJ and suggest that these binding sites comprise a "molecular parking lot" in which the AChE molecules can be released, retained, and turned over.
The lipid transporter Mfsd2a maintains pulmonary surfactant homeostasis (2022)

Pulmonary surfactant is a lipoprotein complex essential for lung function, and insufficiency or altered surfactant composition is associated with major lung diseases, such as acute respiratory distress syndromes, idiopathic pulmonary fibrosis, and chronic obstructive pulmonary disease. Pulmonary surfactant is primarily composed of phosphatidylcholine (PC) in complex with specialized surfactant proteins and secreted by alveolar type 2 (AT2) cells. Surfactant homeostasis on the alveolar surface is balanced by the rates of synthesis and secretion with reuptake and recycling by AT2 cells, with some degradation by pulmonary macrophages and loss up the bronchial tree. However, whether phospholipid (PL) transporters exist in AT2 cells to mediate reuptake of surfactant PL remains to be identified. Here, we demonstrate that major facilitator superfamily domain containing 2a (Mfsd2a), a sodium-dependent lysophosphatidylcholine (LPC) transporter, is expressed at the apical surface of AT2 cells. A mouse model with inducible AT2 cell-specific deficiency of Mfsd2a exhibited AT2 cell hypertrophy with reduced total surfactant PL levels because of reductions in the most abundant surfactants, PC containing dipalmitic acid, and PC species containing the omega-3 fatty acid docosahexaenoic acid. These changes in surfactant levels and composition were mirrored by similar changes in the AT2 cell lipidome. Mechanistically, direct tracheal instillation of fluorescent LPC and PC probes indicated that Mfsd2a mediates the uptake of LPC generated by pulmonary phospholipase activity in the alveolar space. These studies reveal that Mfsd2a-mediated LPC uptake is quantitatively important in maintaining surfactant homeostasis and identify this lipid transporter as a physiological component of surfactant recycling.
Flip angle profile correction for T1 and T2 quantification with look‐locker inversion recovery 2D steady‐state free precession imaging (2012)

Fast methods using balanced steady-state free precession have been developed to reduce the scan time of T₁ and T₂ mapping. However, flip angle (FA) profiles created by the short radiofrequency pulses used in steady-state free precession deviate substantially from the ideal rectangular profile, causing T₁ and T₂ mapping errors. The purpose of this study was to develop a FA profile correction for T₁ and T₂ mapping with Look-Locker 2D inversion recovery steady-state free precession and to validate this method using 2D spin echo as a reference standard. Phantom studies showed consistent improvement in T₁ and T₂ accuracy using profile correction at multiple FAs. Over six human calves, profile correction provided muscle T₁ estimates with mean error ranging from excellent (-0.6%) at repetition time/FA = 18 ms/60° to acceptable (6.8%) at repetition time/FA = 4.9 ms/30°, while muscle T₂ estimates were less accurate with mean errors of 31.2% and 47.9%, respectively.
High-speed memory architectures for multimedia applications (1997)

In order to meet the requirements for multimedia applications, several approaches to DRAM architecture have emerged. Instead of a single, common memory device, several advanced approaches, such as extended data out (EDO) DRAM, and synchronous DRAM (SDRAM) will each play a major role in the future memory market. Furthermore, advanced interface technologies, such as Rambus RAM (RDRAM), RamLink, and SyncLink are very promising for future-generation memory. Also, application-specific memory, such as cache DRAM (CDRAM), enhanced DRAM (EDRAM), and video DRAM (VRAM) offer unique characteristics to improve performance in particular applications. Since it is beneficial to understand which type of high-speed memory can improve the speed performance of a particular system most effectively, this article discusses the fundamental concepts of these recent high-speed performance memory architectures to aid in the selection of memories for multimedia applications.