gebhart/patrepeval huggingface dataset:
416: The Impact of Altered Annexin I Protein Levels on Apoptosis and Signal Transduction Pathways in Prostate Cancer Cells (2006)

You have accessJournal of UrologyDiscussed Poster, Sunday, May 21, 2006, 1:00 - 4:00 pm1 Apr 2006416: The Impact of Altered Annexin I Protein Levels on Apoptosis and Signal Transduction Pathways in Prostate Cancer Cells Toshiyuki Tsunoda, Alice Lau, Darren R. Tyson, and David K. Ornstein Toshiyuki TsunodaToshiyuki Tsunoda More articles by this author , Alice LauAlice Lau More articles by this author , Darren R. TysonDarren R. Tyson More articles by this author , and David K. OrnsteinDavid K. Ornstein More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)32672-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "416: The Impact of Altered Annexin I Protein Levels on Apoptosis and Signal Transduction Pathways in Prostate Cancer Cells." The Journal of Urology, 175(4S), pp. 135–136 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 135-136 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Toshiyuki Tsunoda More articles by this author Alice Lau More articles by this author Darren R. Tyson More articles by this author David K. Ornstein More articles by this author Expand All Advertisement Loading ...
Mapping the anatomy of the immunodominant domain of the human immunodeficiency virus gp41 transmembrane protein: peptide conformation analysis using monoclonal antibodies and proton nuclear magnetic resonance spectroscopy (1991)

Thirty-six monoclonal antibodies from mice and three from rats were raised against a peptide corresponding to the immunodominant domain of the transmembrane gp41 protein of human immunodeficiency virus (HIV) type 1 (LGLWGCSGKLIC; amino acid residues 598 to 609). Of these, three monoclonal antibodies from the mice and one from a rat also reacted with the corresponding peptide derived from the HIV type 2 transmembrane gp41 protein (amino acid residues 593 to 603; NSWGCAFRQVC). Immunochemical studies using a variety of synthetic peptides indicated that the cross-reactivity was due to antibody binding to CSGKLIC of HIV type 1 or CAFRQVC of HIV type 2. Single amino acid substitutions for a cysteine at either the amino or the carboxy end of the peptide interrupted antibody binding, indicating that the site recognized was the Cys-XXXXX-Cys loop. Similar results were obtained when the 11-mer HIV type 2 gp41 peptide (amino acids 593 to 603) was inoculated into mice to raise monoclonal antibodies. In this instance, of 30 monoclonal antibodies developed, 4 reacted with both HIV type 1 and HIV type 2 peptides. The conformation of a seven-residue peptide, CSGKLIC, corresponding to residues 603 to 609 of the gp41 immunodominant epitope of HIV-1 was investigated by proton nuclear magnetic resonance spectroscopy. The immunologically active form of CSGKLIC contains an intramolecular disulfide bond and maintains a preference for a folded conformation, apparently including a type I reverse turn about the residues SGKL. No such preference is observed for the reduced form of the peptide, which contains two thiol groups. The presence of the disulfide bond is thus integral to the formation of the structure of the loop in solution. In agreement with this finding, elimination of the possibility of loop formation by substitution of S for C at the amino or carboxy termini of the 7-mer is accompanied by the failure of antibody binding to this peptide.
Locking frequency band exposure method for islanding detection and prevention in distributed generation (2014)

This paper presents a novel active method in islanding detection for distributed generation and microgrids. The proposed method, Locking Frequency Band Exposure (LFBE) is a software-based algorithm that utilizes the microgrid frequency. When power demand in the microgrid exceeds the power generation, frequency falls and when the power demand from the grid matches very closely to that of local generation, the frequency does not vary appreciably. In this method, by measuring the variations of command frequency which is created by adding some disturbance to the sampled frequency at the PCC, islanding can be detected. Assuming the exact power match in the microgrid, Tank or Islanding conditions are experienced. It is also possible to discriminate between these two conditions from the microgrid's behavior. This proposed method of detection is shown to be robust, able to detect both islanding and tank, and simple to be implemented.
60 GHz VCO with wideband tuning range fabricated on VLSI SOI CMOS technology (2004)

A 60 GHz cross-coupled differential LC CMOS VCO is presented in this paper, which is optimized for a large frequency tuning range using conventional MOSFET varactors. The MMIC is fabricated on digital 90 nm SOI technology and requires a circuit area of less than 0.1 mm/sup 2/ including the 50 /spl Omega/ output buffers. Within a frequency control range from 52.3 GHz to 60.6 GHz, a supply voltage of 1.5 V and a supply current of 15 mA, the circuit dividers a very constant output power of -6.8 /spl plusmn/ 0.2 dBm and yields a phase noise between -85 to -92 dBc/Hz at 1 MHz frequency offset.
CMOS Compatible Nanoscale Nonvolatile Resistance Switching Memory (2008)

We report studies on a nanoscale resistance switching memory structure based on planar silicon that is fully compatible with CMOS technology in terms of both materials and processing techniques employed. These two-terminal resistance switching devices show excellent scaling potential well beyond 10 Gb/cm2 and exhibit high yield (99%), fast programming speed (5 ns), high on/off ratio (10(3)), long endurance (10(6)), retention time (5 months), and multibit capability. These key performance metrics compare favorably with other emerging nonvolatile memory techniques. Furthermore, both diode-like (rectifying) and resistor-like (nonrectifying) behaviors can be obtained in the device switching characteristics in a controlled fashion. These results suggest that the CMOS compatible, nanoscale Si-based resistance switching devices may be well suited for ultrahigh-density memory applications.
New Face Recognition Algorithm Adopting Wide Fast Embedded Capsule Networks with Reduced Complexity and Preserved Accuracy (2021)

Computer Vision has come a long way after the introduction of Convolutional Neural Networks, that simulated the first perception layers in the human vision, specially in classification, and segmentation tasks. With Convolutional layers came maximum pooling that is not natural and is the reason for information loss and the lack of preserving spatial information of the patterns, that is why Capsule Networks were introduced. Capsule Networks handle patterns as vectors preserving spatial information of the patterns along with their pose but at the cost of having slow processing and high complexity. Wide Fast Embedded Capsule Networks were introduced as the faster and simpler version of Capsule Networks. However, they could not handle complex datasets like Labeled Faces in the Wild (LFW). That is the reason Wide Fast Embedded Capsule Networks are proposed in this paper to handle intermediate complex datasets like LFW boosting the speed boost, reducing complexity and preserving accuracy. Experimental results show that the speed is tripled, the complexity is reduced by 80.6% and the accuracy is preserved at 93.7%.
ChemInform Abstract: Synthesis of the Antifungal 1‐Benzoxepin Pterulone. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
New Synthetic Routes to Biologically Interesting Geranylated Flavanones and Geranylated Chalcones: First Total Synthesis of (±)‐Prostratol F, Xanthoangelol, and (±)‐Lespeol (2010)

Abstract A new and efficient synthetic approach to biologically interesting geranylated flavanones and geranylated chalcones is described. Thus, the first total syntheses of the geranylated flavanones (±)‐prostratol F ( 1 ), (±)‐8‐geranyl‐3′,4′,7‐trihydroxyflavanone ( 2 ), and (±)‐6‐geranyl‐5,7‐dihydroxy‐3′,4′‐dimethoxyflavanone ( 3 ) were carried out starting from 2,4‐dihydroxyacetophenone ( 10 ) and 2,4,6‐trihydroxyacethophenone ( 17 ) in five to six steps ( Schemes 2 and 3 ). The geranylated chalcones xanthoangelol ( 4 ), 3‐geranyl‐2,3′,4,4′‐tetrahydroxychalcone ( 5 ), (±)‐lespeol ( 6 ), and lespeol derivatives (±)‐ 7 – 9 were synthesized starting from 2,4‐dihydroxyacetophenone ( 10 ) in three to four steps ( Schemes 2 and 6 ).
Protecting your daily in-home activity information from a wireless snooping attack (2008)

In this paper, we first present a new privacy leak in residential wireless ubiquitous computing systems, and then we propose guidelines for designing future systems to prevent this problem. We show that we can observe private activities in the home such as cooking, showering, toileting, and sleeping by eavesdropping on the wireless transmissions of sensors in a home, even when all of the transmissions are encrypted. We call this the Fingerprint and Timing-based Snooping (FATS) attack. This attack can already be carried out on millions of homes today, and may become more important as ubiquitous computing environments such as smart homes and assisted living facilities become more prevalent. In this paper, we demonstrate and evaluate the FATS attack on eight different homes containing wireless sensors. We also propose and evaluate a set of privacy preserving design guidelines for future wireless ubiquitous systems and show how these guidelines can be used in a hybrid fashion to prevent against the FATS attack with low implementation costs.
British News:The ‘Great Anti-Racist Show’? (2002)

In a recent account of the sociology of journalism, Brian McNair claims that 'racism is dying' and that racists are 'increasingly isolated, finding no endorsement of their views from the media' (1998: 31). As this chapter will show, McNair is tragically wrong. The extent to which news media continue to shape the process of racialisation in a variety of terrains, particularly those of crime, social pathology, migration and both normative and progressive whiteness requires careful scrutiny. The capacity for renewal of hostile news messages about groups who are positioned outside the white nation by news producers is regularly demonstrated year after year. Running alongside this significant core of racial hostility and migrant animosity is a parallel set of news stories which counterpose and document an undeniable message of social inclusion, opposition to racism and a vision of racial justice. The nature, scope and extent of these opposing news themes is the focus of this and subsequent chapters.
Ambulatory Extracorporeal Membrane Oxygenation (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Reconfigurable Computing (2014)

This introduction to the special section on Reconfigurable Computing briefly discusses the history and current state of the field and introduces the articles in the special section.
Combining Gold and Photoredox Catalysis: Visible Light-Mediated Oxy- and Aminoarylation of Alkenes (2013)

A room-temperature intramolecular oxy- and aminoarylation of alkenes with aryldiazonium salts has been developed using a novel gold and photoredox dual-catalytic system. The compatibility of these two catalytic modes has been established for the first time and demonstrates the potential of this system as a method to expand the scope of nucleophilic addition reactions to carbon-carbon multiple bonds.
A Power-Aware Test Methodology for Multi-Supply Multi-Voltage Designs (2008)

This paper describes the challenges of testing low-power designs that use the commonly used multi-supply multi-voltage (MSMV) and power shut-off (PSO) design methodology. We describe a novel solution to address the manufacturing test of an MSMV/PSO design by using power-mode specifications to map multiple power modes to their target test modes and enhancing the DFT and ATPG methodology to enable a comprehensive test methodology. We provide experimental results and future directions for power-aware test.
The Lehman Brothers Bankruptcy A: Overview (2014)

On September 15, 2008, Lehman Brothers Holdings, Inc., the fourth-largest U.S. investment bank, sought Chapter 11 protection, initiating the largest bankruptcy proceeding in U.S. history. The demise of the 164-year old firm was a seminal event in the global financial crisis. Under the direction of its long-time Chief Executive Officer Richard Fuld, Lehman had been very successful pursuing a high-leverage, high-risk business model that required it to daily raise billions of dollars to fund its operations. Beginning in 2006, Lehman began to invest aggressively in real-estate-related assets and soon had significant exposures to housing and subprime mortgages, just as these markets began to sour. Lehman employed a cadre of accountants and risk professionals to continually monitor its balance sheet, key ratios, and risks. It undertook desperate and some questionable actions to stay alive. Nevertheless, Lehman ultimately failed because of an inability to finance itself. This overview case provides background information about Lehman’s business and key personnel and also the economic environment during 2006-2008. It may be utilized individually or in connection with any of the other seven YPFS Lehman case studies.
Smoking Behavior in Arab Americans: A Systematic Review (2016)

Background: In the United States (US), Arab Americans who maintain traditional cultural norms after their immigration are more likely to continue smoking as a form of social interaction. Arab Americans and their families are at a high risk for poor health outcomes related to smoking. Objective: This systematic review aimed to explore the smoking behavior, prevalence and use among Arab Americans and examine studies addressing the effect of acculturation on this behavior. Results: The majority of the studies included focused on smoking prevalence and cessation. Some discussed the impact of acculturation and health beliefs on the smoking behavior of Arab American adolescents. Only two smoking cessation programs have been developed for Arab Americans, despite the high prevalence of both cigarette and water-pipe smoking in this community. Conclusion: The scarcity of research on smoking among Arab Americans has impeded the development of interventions that improve health outcomes and reduce health disparities.
A 70 Gbps 16:1 Multiplexer and a 60 Gbps 1:16 Demultiplexer in a SiGe BiCMOS Technology (2006)

The authors present circuits for at-rate processing of high speed serial data for optical communication applications, implemented in the IBM 8HP SiGe BiCMOS technology. Specifically, the authors describe a 16:1 multiplexer and a 1:16 demultiplexer, each assembled into a package designed to support 80 Gbps data rates. The maximum speed of the packaged components (multiplexer: 70 Gbps, demultiplexer: 60 Gbps) is among the highest reported to date for this generation SiGe technology, particularly for circuits with this level of complexity (>10,000 transistors)
A serum heterodimer from hagfish (Eptatretus stoutii) exhibits structural similarity and partial sequence identity with immunoglobulin. (1991)

We have isolated, characterized, and partially sequenced immunoglobulin from the most primitive extant nonvertebrate craniate, the hagfish, a jawless fish that may have diverged from the vertebrate lineage more than 500 million years ago. The 160-kDa protein, which is a minor serum component, is composed of two different heavy chains of 69 and 74 kDa and a light chain of 29 kDa and resembles known immunoglobulin on the basis of an equimolar ratio of heavy and light chains, N-linked glycosylation of heavy chains, presence of intra- and interchain disulfide bonds, and polydispersity of each peptide chain. High molecular mass (polymeric) as well as low molecular mass (monomeric) forms were isolated from serum. The hagfish immunoglobulin is unique in that each heterodimer is composed of two different heavy chains and two light chains. The partial peptide maps and amino acid compositions of the two heavy chains differ; the chains do not crossreact immunologically. Slight crossreactivity of the 74-kDa heavy chain with antisera against purified shark immunoglobulin and some conservation of amino acid sequences, including those surrounding a cysteine, suggest that the isolated protein is an immunoglobulin.
Development of Pt-Co-Mn Ternary Alloy Catalyst for PEFCs (2014)

In this study, PtCoX (X = Mn, Ni, Fe, Cr, Ti, Cu, Zn, Mo, V, Sn, In, Pd, Ir, Ru, Au) / High surface area carbon (HSAC) ternary alloys catalysts were synthesized and investigated about activity for the oxygen reduction reaction (ORR). PtCoMn / C showed the highest activity for ORR in all catalysts evaluated. XRD studies showed the formation of Pt 3 Mn and Pt 3 Co in the alloy structure by applying high temperature heat treatment. This result suggests that the mixture of Pt 3 Mn and Pt 3 Co alloys are highly active species for oxygen reduction reaction.
Improved Mycobacterium tuberculosis clearance after the restoration of IFN‐γ + TNF‐α + CD4 + T cells: Impact of PD‐1 inhibition in active tuberculosis patients (2020)

Abstract Prolonged therapy, drug toxicity, noncompliance, immune suppression, and alarming emergence of drug resistance necessitate the search for therapeutic vaccine strategies for tuberculosis (TB). Such strategies ought to elicit not only IFN‐γ, but polyfunctional response including TNF‐α, which is essential for protective granuloma formation. Here, we investigated the impact of PD‐1 inhibition in facilitating protective polyfunctional T cells (PFTs), bacillary clearance, and disease resolution. We have observed PD‐1 inhibition preferentially rescued the suppressed PFTs in active tuberculosis patients. In addition, polyfunctional cytokine milieu favored apoptosis of infected MDMs over necrosis with markedly reduced bacillary growth (≪CFU) in our in vitro monocyte‐derived macrophages (MDMs) infection model. Furthermore, the animal study revealed a significant decline in the bacterial burden in the lungs and spleen of infected mice after in vivo administration of α‐PD‐1 along with antitubercular treatment. Our findings suggest that rescuing polyfunctional immune response by PD‐1 inhibition works synergistically with antituberculosis chemotherapy to confer improved control over bacillary growth and dissemination. In summary, our data strongly indicate the therapeutic potential of α‐PD‐1 as adjunct immunotherapy that can rejuvenate suppressed host immunity and enhance the efficacy of candidate therapeutic vaccine(s).
Sequence requirements for self-splicing of theTetrahymena thermophilapre-ribosomal RNA (1985)

The sequence requirements for splicing of the Tetrahymena pre-rRNA have been examined by altering the rRNA gene to produce versions that contain insertions and deletions within the intervening sequence (IVS). The altered genes were transcribed and the RNA tested for self-splicing in vitro. A number of insertions (8-54 nucleotides) at three locations had no effect on self-splicing activity. Two of these insertions, located at a site 5 nucleotides preceding the 3'-end of the IVS, did not alter the choice of the 3' splice site. Thus the 3' splice site is not chosen by its distance from a fixed point within the IVS. Analysis of deletions constructed at two sites revealed two structures, a hairpin loop and a stem-loop, that are entirely dispensable for IVS excision in vitro. Three other regions were found to be necessary. The regions that are important for self-splicing are not restricted to the conserved sequence elements that define this class of intervening sequences. The requirement for structures within the IVS for pre-rRNA splicing is in sharp contrast to the very limited role of IVS structure in nuclear pre-mRNA splicing.
A Prudent Decision (2011)

An updated prudential agreement regime could soon be introduced. Alan Graham questions whether this will be beneficial or whether it will simply create more compliance for the sector.
transmission of the Ambystoma tigrinum virus to alternative hosts (2001)

Ambystoma tigrinum virus (ATV) is a lethal virus originally isolated from Sonora tiger salamanders Ambystoma tigrinum stebbinsi in the San Rafael Valley in southern Arizona. USA. ATV is implicated in several salamander epizootics. We attempted to transmit ATV experimentally to fish and amphibians by injection, water bath exposure, or feeding to test whether ATV can cause clinical signs of infection or be recovered from exposed individuals that do not show clinical signs. Cell culture and polymerase chain reaction of the viral major capsid protein gene were used for viral detection. Salamanders and newts became infected with ATV and the virus was recovered from these animals, but virus could not be recovered from any of the frogs or fish tested. These results suggest that ATV may only infect urodeles and that fish and frogs may not be susceptible to ATV infection.