gebhart/patrepeval huggingface dataset:
SONAR: a platform for flexible DiffServ/MPLS traffic engineering (2005)

A major opportunity for IP network operators to increase the revenue stream generated by their network is a closer and faster integration of services into the IP broadband network. However, with this integration come responsibilities concerning the quality, availability and continuity of these services, which are much harder to fulfil than the requirements for the current IP data traffic. SONAR (service-oriented networking using adaptive resource control) is a network management and operations platform designed to drive a DiffServ/MPLS network so that these responsibilities can be met. In this paper we discuss and evaluate the architecture and algorithms that are the basis for this platform. The architecture decomposes the network management problem in two components: a centralised path computation and a distributed tunnel management. Finally this hybrid on line/off line adaptive traffic engineering approach is evaluated in an modified NS-2 simulator environment.
Cluster-head Decision Method for Cognitive Radio Based on Wireless Ad-hoc Network (2012)

Ad-hoc networks can be used various environment, which it is difficult to construct infrastructures, such as shadowing areas, disaster areas, war area, and so on. In order to support to considerable and various wireless services, more spectrum resources are needed. However, efficient utilization of the frequency resource is difficult because of spectrum scarcity and the conventional frequency regulation. Ad-hoc networks employing cognitive radio (CR) system that guarantee high spectrum utilization provide effective way to increase the network capacity. In CR based wireless ad-hoc networks, cluster-head decides the existence of primary user using sensing information of primary user from each ad-hoc device. However, it is still defective research to decide cluster head among the a lot of ad-hoc devices. So, in this paper, we show the decision method of cluster head in CR based wireless and detection probabilities of primary user based on decision method of cluster head.
A modified bonded model approach for molecular dynamics simulations of New Delhi Metallo-β-lactamase (2023)

Modelling metalloproteins using the classical force fields is challenging. Several methods have been devised to model metalloproteins in force fields. Of these methods, the bonded model, combined with Restrained Electrostatic Potential (RESP) charge fitting, proved its superiority. The latter method was facilitated by the development of the python-based Metal Centre Parameter Builder (MCPB.py) AmberTool. However, the standard bonded model method offered by the MCPB.py tool may not be appropriate for validating and refining the binding modes predicted by docking when crystal structures are lacking. That is because the representation of coordination interactions between any bound ligand and metal ions by covalent bonds can hinder the flexibility of the ligand. Therefore, a new modification to the standard bonded model approach is proposed here. Molecular dynamics (MD) simulations based on the new modified bonded model (MBM) approach avoid the bias caused by coordination bonds and, unlike hybrid QM/MM MD, allow for sufficient sampling of the binding mode given the currently available computational power. The MBM MD approach reproduced the studied crystal structure conformations of New Delhi Metallo-β-lactamase 1 (NDM-1). Furthermore, the MBM approach described the binding interactions of intact β-lactams with NDM-1 reasonably, and predicted a non-productive binding mode for the poor NDM-1 substrate aztreonam whilst predicting productive binding modes for known good substrates. This study presents a useful MD method for metallo-β-lactamases and provides better understanding of β-lactam substrates recognition by NDM-1. The proposed MBM approach might also be useful in the investigation of other metal-containing protein targets.
SELF- AND AIR-BROADENED LINEWIDTHS OF FORMAL--DEHYDE (1977)

Author Institution: Ames Laboratory-ERDA and Department of Chemistry, Iowa State University
Enantioselective Cross‐couplings between Halide Derivatives and Organometallics by Using Iron and Cobalt Catalysts: Formation of C−C Bonds (2021)

This review highlights the recent achievements of iron- and cobalt-catalyzed enantioselective cross-couplings of halide derivatives with organometallic reagents for the construction of C-C bonds. Synthetic applications of enantioselective cross-couplings to natural products and biologically active compounds are also covered showing the power of these cross-couplings in organic synthesis.
Improving Point-of-Care Testing with Automated Identification Technologies (2005)

From the Massachusetts General Hospital, Boston, Massachusetts. Reprints: Anand Dighe, MD, PhD, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (e-mail: [email protected]).
Integrating Piece and Peer Selection in Content Distribution Networks (2015)

Content Distribution Networks (CDNs) could benefit from peer-to-peer (P2P) network techniques to improve content delivery time by leveraging the upload capacity of the entire network. In most available solutions, peers first select a set of partners, and later select the pieces of content to exchange. It is fundamental instead that both peer and piece selection algorithms are performed in a consistent and integrated way. To this aim, we propose a content distribution protocol that unifies piece and peer selection in a single algorithm which optimizes the swarming effects. Our approach leverages Flajolet-Martin sketches, a technique based on Bloom filters, to estimate the number of distinct pieces in the CDN, and then adopts a fractional knapsack problem approach to effectively utilize the entire upload capacity of each peer. We tested our solution with both simulations and Planetlab experiments, showing how the piece estimation at every peer is a good approximation of the global rarest piece across the network, and not just across the first hop neighborhood. Moreover, we show how our solution improves the average downloading time by up to 20%. If we consider only the fastest 50% of peers, the downloading time is improved by 100%. Furthermore, our solution decreases the average first content uploading time by 80% with respect to standard P2P protocols which use a local rarest first piece selection, and tit-for-tat as peer selection algorithm.
YmdB: a stress-responsive ribonuclease-binding regulator of E. coli RNase III activity (2008)

The broad cellular actions of RNase III family enzymes include ribosomal RNA (rRNA) processing, mRNA decay, and the generation of noncoding microRNAs in both prokaryotes and eukaryotes. Here we report that YmdB, an evolutionarily conserved 18.8-kDa protein of Escherichia coli of previously unknown function, is a regulator of RNase III cleavages. We show that YmdB functions by interacting with a site in the RNase III catalytic region, that expression of YmdB is transcriptionally activated by both cold-shock stress and the entry of cells into stationary phase, and that this activation requires the sigma-factor-encoding gene, rpoS. We discovered that down-regulation of RNase III activity occurs during both stresses and is dependent on YmdB production during cold shock; in contrast, stationary-phase regulation was unperturbed in YmdB-null mutant bacteria, indicating the existence of additional, YmdB-independent, factors that dynamically regulate RNase III actions during normal cell growth. Our results reveal the previously unsuspected role of ribonuclease-binding proteins in the regulation of RNase III activity.
Synthesis and Reactivity of Novel 1H-Isochromeno[3,4-d]imidazol-1-onium Salts (2011)

A straightforward and convenient preparation of 25 novel imidazolium salts from the corresponding 1H-isochromeno [3,4-d]imidazolones is described, employing either a quaternization or a quaternization/anion metathesis strategy.
Editor's evaluation: Selective androgen receptor degrader (SARD) to overcome antiandrogen resistance in castration-resistant prostate cancer (2021)

The rational drug design combining the bioassay identified a novel selective androgen receptor (AR) degrader for both AR and AR-VRs and illustrated the synergistic importance of AR antagonism and degradation in advanced prostate cancer treatment.
Innovative Approach to the Accumulation of Rubrosterone by Fermentation of Asparagus filicinus with Fusarium oxysporum (2015)

Rubrosterone, possessing various remarkable bioactivities, is an insect-molting C19-steroid. However, only very small amounts are available for biological tests due to its limited content from plant sources. Fungi of genus Fusarium have been reported to have the ability to convert C27-steroids into C19-steroids. In this study, Asparagus filicinus, containing a high content of 20-hydroxyecdysone, was utilized to accumulate rubrosterone through solid fermentation by Fusarium oxysporum. The results showed that F. oxysporum had the ability to facilitate the complete biotransformation of 20-hydroxyecdysone to rubrosterone by solid-state fermentation. The present method could be an innovative and efficient approach to accumulate rubrosterone with an outstanding conversion ratio.
A New Method for the One-Step Synthesis of α,β-Unsaturated Carbonyl Systems from Saturated Alcohols and Carbonyl Compounds (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA New Method for the One-Step Synthesis of α,β-Unsaturated Carbonyl Systems from Saturated Alcohols and Carbonyl CompoundsK. C. Nicolaou, Y.-L. Zhong, and P. S. BaranView Author Information Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, California 92037 Department of Chemistry and Biochemistry University of California, San Diego 9500 Gilman Drive, La Jolla, California 92093 Cite this: J. Am. Chem. Soc. 2000, 122, 31, 7596–7597Publication Date (Web):July 21, 2000Publication History Received25 May 2000Published online21 July 2000Published inissue 1 August 2000https://pubs.acs.org/doi/10.1021/ja001825bhttps://doi.org/10.1021/ja001825brapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views20943Altmetric-Citations342LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Addition reactions,Alcohols,Carbonyls,Ketones,Oxidation Get e-Alerts
Chemical tuning of CO2 sorption in robust nanoporous organic polymers (2011)

We report here the carbon dioxide sorption properties for a series of conjugated microporous polymer (CMP) networks. These CMP materials incorporate a range of chemical functionalities including carboxylic acids, amines, hydroxyl groups, and methyl groups. The carboxylic acid functionalised network, rather than its amine analogue, shows the highest isosteric heat of sorption for CO2. This supports recent computational predictions for metal–organic frameworks and suggests that acid-functionalised frameworks could outperform more widely studied amine sorbents in CO2 capture and separation application.
Pyridine-di-phosphonates as chelators for trivalent f-elements: kinetics, thermodynamic and interfacial study of Am(iii)/Eu(iii) solvent extraction (2022)

The fractionation of high-level radioactive waste from nuclear power plants simplifies the handling of its components, and facilitates the reduction of radiotoxic effects on the environment. The search and study of new ligands for solvent extraction, as one of the methods in fractionation, remains a complex and important research task. In this work, four pyridine diphosphonate ligands were synthesized. These ligands are part of the class of the N,O-donor extractants, which are selective towards Am(III). The separation factor SF(Am/Eu) for the best extractant reached values up to 10. The influence of the substituents on the efficiency of extraction and complexation of trivalent f-elements, the kinetics of extraction, and the behavior of the ligand at the interface were described. The effect of nitric acid concentration on the extraction was shown. The stoichiometry of the complexes was determined by slope analysis in solvent extraction experiment and verified by spectrophotometric titration in acetonitrile. Liquid tension experiments with a pendant drop method revealed the interfacial properties of the ligands in "F-3 solvent/H<sub>2</sub>O" and "F-3 solvent/HNO<sub>3</sub>" systems. The relationship between the surface activity and the ligand structure was shown. Studies of the extraction kinetics were performed in a modified Lewis cell. The effect of the ligand structure on the extraction rate was shown. The DFT calculation with the B3LYP density functional was used to explain the extraction properties of the ligands, including selectivity. The calculation of the pre-organization energy of the ligands explained the kinetics and extraction patterns for the studied series.
Expression, Subcellular Distribution and Plasma Membrane Binding of Cathepsin B and Gelatinases in Bone Metastatic Tissue (1996)

The possible application of proteinase inhibitors in the support of anti-tumor chemotherapy requires profound knowledge of the proteinases involved in malignant processes. Therefore, the occurrence of cathepsins B, D, H, L and S and of gelatinases, urokinase plasminogen activator and stromelysins was studied in biopsies of aggressive human bone metastases, of low invading basal cell carcinomas, and in normal placenta as control, by activity measurements and zymographic techniques. Cathepsin B and L, as well as gelatinase B, were shown to be overexpressed in bone metastases, suggesting a function during the metastatic process. Subcellular fractionation allowed detection of differential sorting of cathepsin B and gelatinases in metastatic tissue and also in normal human placenta. Plasma membrane binding could be demonstrated for both cathepsin B and gelatinase B. Whereas cathepsin B is at least partially bound to plasma membranes via alpha 2-macroglobulin and its LRP/alpha 2-macroglobulin receptor, gelatinase B binds to plasma membranes by an unknown mechanism.
[Studies on the prenatally toxic effect of parathionemethyl in Wistar rats compared to cyclophosphamide and trypan blue]. (1976)

Higher yield and performance in plant and animal production will depend on reinforced use of pesticides, particularly alkyl phosphate esters and insecticidal carbamates. Prenatal toxic action of the pesticides used today may be detrimental to human and animal health. Prenatal-toxicological tests, using parathion-methyl, were conducted on the basis of known but modified experimental methods. The vulnerability of a rat strain was tested by applying to it teratogenic model substances (trypan blue and cyclophosphamide). Several oral applications of parathion-methyl (3 ppm) during the sensitive phases of germ formation and growth (fifth to ninth and eleventh to fifteenth or eleventh to nineteenth days from conception) were followed by clear embryotoxic effects, such as retardation and increased resorption. The average number of resorption sites grew from nine in the control group to 20 in the experimental group. Postnatal malformations were not observed.
Studies on the effect of 17alpha-ethinyl-6-estrene-5alpha, 7beta-diol on menstrual cycle and plasma and urinary hormones in normal women. (1975)

Pharmacological tests on rats and dogs showed that a novel steroid substance, ORG OI-65 (code name for 17alpha-ethinyl-6-estrene-5alpha, 7beta-diol) has both progestational and estrogenic properties. The effect of this substance on menstrual cycle was studied on 13 healthy fertile women, who received 2 mg of ORG OI-65 daily for 20 consecutive days from the 5th day of cycle. The following parameters were studied during pretreatment and treatment cycles: bleeding pattern, plasma progesterone, urinary excretion of FSH, LH and estrone, vaginal cytology, cervical mucus, endometrium biopsy and basal body temperature. Treatment with ORG OI-65 did not change the bleeding pattern or inhibit ovulation: all 12 cases with ovulatory pretreatment cycles showed evidence of ovulation--timely or delayed--also during ORG OI-65 treatment. The vaginal cytology and cervical mucus remained almost unaffected by the treatment. No serious side-effects were found. The authors conclude that ORG OI-65 2 mg daily is not effective enough for oral contraception.
ChemInform Abstract: H + H2: The Current Status (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Encoding speech in cochlear implants using simultaneous amplitude and rate modulation (2018)

To improve speech perception for cochlear implant (CI) users, it is essential to improve the transmission of temporal envelopes. The most common speech processors deliver temporal envelopes via the CI using fixed-rate amplitude modulated (AM) pulse trains. Psychophysical studies suggest that rate modulation (RM) and AM are perceived by a shared temporal integration mechanism, but the potential for them to constructively combine to encode temporal envelopes has yet to be explored. In this experiment, a speech processing strategy called amplitude and rate temporal modulation was developed to encode speech temporal envelopes with simultaneous AM and RM. The strategy was tested for perception of clean speech at 60 and 40 dBA, and 60 dBA speech in noise (+10 dB SNR). The amount of RM was varied and the amount of AM was held constant to determine whether the addition of RM could enhance the perception of temporal envelopes and improve speech understanding. At the lowest RM amount, speech scores were poorest for all speech conditions. For 60 dBA clean speech and speech in noise, speech scores were significantly better at the highest RM amounts, suggesting that RM combined with AM can be used to enhance perception of temporal envelopes.
Thiosulfate Pharmacokinetics in Normal and Anuric Dogs (1982)

Cyanide (CN) toxicity has recently become increasingly a clinical problem with the greater use of Laetrile for cancer treatment and of sodium nitroprusside for blood pressure control. Sodium thiosulfate is an excellent antidote for CN toxicity but not all aspects of its pharmacokinetics have been adequately studied. Applying a specific thiosulfate assay, we measured endogenous thiosulfate, the response to CN infusion, and disappearance after iv injection in normal and anuric dogs. Endogenous plasma concentration was approximately 1 mg/dl; the bile concentration was 15 times higher but biliary excretion accounted for less than 2%, compared to renal excretion. Cyanide infusion decreased endogenous plasma thiosulfate 33% before death. The fast component of the thiosulfate disappearance curve was similar, 3 min, after iv injection (150 mg/kg), while the second component was markedly prolonged in anuric dogs (239 min) compared to controls (47 min). Therefore, a constant infusion of thiosulfate would appear to be the best method of maintaining the high plasma concentration necessary for CN detoxification during the continuous administration or absorption of CN-producing compounds.
1,3‐Dipolar Cycloadditions in the Synthesis of Carbohydrate Mimics. Part 3. Azides, Diazo Compounds and Other Dipoles (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Architectures supramoléculaires sur la surface de Si(111)-B (2014)

National audience
A HIGH-BRIGHTNESS PRE-ACCELERATED RF-PHOTO INJECTOR (2002)

At Eindhoven University of Technology a project has started aiming at the production of 100 fs, 100 pC electron bunches, with an emittance below 1 π mm mrad. These bunches are compatible with the requirements for a plasma wakefield accelerator or can be used to generate ultra-short XUV/X-ray pulses. The device currently under construction consists of two stages: A photoexcited DC 1 GV/m pre-accelerator, directly followed by a state-of-the-art S-band rf-booster. The field in the first stage is sufficiently high to avoid space-charge explosion at low energies. Therefore magnetic compression is not needed and this in turn eliminates undesirable radiative collective effects, which spoil the emittance. The 1 GV/m field is created in a 2 mm acceleration gap, powered by a 2 MV, 1 ns pulse generator. The second stage increases the energy to 10 MeV using a 100 MV/m 2.5 cell standing wave cavity with axial symmetric incoupling. Simulation results using the GPT code for the combined setup are presented.