gebhart/patrepeval huggingface dataset:
Methods to Monitor Fatty Acid Transport Proceeding Through Vectorial Acylation (2009)

The process of fatty acid transport across the plasma membrane occurs by several mechanisms that involve distinct membrane-bound and membrane-associated proteins and enzymes. Among these are the fatty acid transport proteins (FATP) and long-chain acyl CoA synthetases (Acsl). Previous studies in yeast and adipocytes have shown FATP and Acsl form a physical complex at the plasma membrane and are required for fatty acid transport, which proceeds through a coupled process-linking transport with metabolic activation termed vectorial acylation. At present, six isoforms of FATP and five isoforms of ACSL have been identified in mice and man. In addition, there are a number of splice variants of different FATP and Acsl isoforms. The different FATP and Acsl isoforms have distinct tissue expression profiles and different cellular locations suggesting they function in the channeling of fatty acids into discrete metabolic pools. The concerted activity of these proteins is proposed to allow cells to discriminate different classes of fatty acids and provides the mechanistic basis underpinning the selectivity and specificity of the fatty acid transport process.
Vitamin B12 Status in Children With Cystic Fibrosis and Pancreatic Insufficiency (2014)

Serum B12 was elevated in the majority of children with CF and PI. Supplement-based B12 intake was 6 to 10 times the RDA, and strongly predicted elevated serum B12 status. The health consequences of lifelong high supplement-based B12 intake and high serum B12 are unknown and require further study, as does the inversed correlation between serum B12 and forced expiratory volume at 1 second.
Management of Myocarditis-Related Cardiomyopathy in Adults (2019)

Myocarditis is generally a mild and self-limited consequence of systemic infection of cardiotropic viruses. However, patients can develop a temporary or permanent impairment of cardiac function including acute cardiomyopathy with hemodynamic compromise or severe arrhythmias. In this setting, specific causes of inflammation are associated with variable risks of death and transplantation. Recent translational studies suggest that treatments tailored to specific causes of myocarditis may impact clinical outcomes when added to guideline-directed medical care. This review summarizes recent advances in translational research that influence the utility of endomyocardial biopsy for the management of inflammatory cardiomyopathies. Emerging therapies for myocarditis based on these mechanistic hypotheses are entering clinical trials and may add to the benefits of established heart failure treatment.
Regional innovation performance: Evidence from domestic patenting in China (2006)

SummaryThis paper empirically studies the determinants of domestic patenting at a regional level in China. Applying a stochastic frontier approach to a panel of data published by China government for 30 provinces from 1998 to 2004, I explore the relationship between domestic patent grants and variables associated with R&D inputs and time-varying nuanced factors. Results imply that region-specific factors affect the efficiency in the production of three types of patents (namely, invention, utility model, design) quite differently. Industrial structure is one influential factor which determines the efficiency levels of all three types of patenting. High technology industries are not as efficient and innovative as expected. Although the role of educational institution and government support is important in patenting inventions and utility models, it is not significant in patenting designs. Firms’ commitment in innovation helps promote the efficiency in patenting utility models and designs only. It does not significantly affect the efficiency in patenting inventions. It is found that the estimated mean efficiency level is higher in the case of utility model patenting than in other two cases, while the production of design patents is found the most inefficient. Ranking regions by an order of estimated mean efficiency levels, I find that a pattern of center–periphery in innovation efficiency is only observed in the case of invention and utility model patenting, not in the case of design patenting.
Reduction of Iron Loss on Grain-oriented Electrical Steel Sheet Using Vector Magnetic Characteristic Control Technology (2023)

In order to develop the high efficiency and low loss in transformer, it is essential to reduce iron loss on grain-oriented electrical steel sheet which is one of transformer loss. On the other hand, it is known that the iron loss increases due to the rotating magnetic flux generated at the T-junction of the transformer core, and it is necessary to deal with this problem. A vector magnetic characteristic control technology has been developed that can reduce iron loss under rotating magnetic flux in existing grain-oriented electrical steel sheets. In this paper, we apply the control technology to the existing low iron loss grain oriented electrical steel sheet with a thickness of 0.23 mm, and report the results of verifying the iron loss reduction effect. In addition, the factor of iron loss change was clarified using the two-frequency separation method. Based on the knowledge obtained, we will propose the application of control technology to transformer cores.
Single-Coil, Multisample, Proton Relaxation Method for Magnetic Relaxation Switch Assays (2008)

Nanoparticle based magnetic relaxation switch (MRSw) biosensors offer the opportunity to develop magnetic resonance based in vitro diagnostics. Critical attributes for point of care in vitro diagnostic products include simple instrumentation and ease of use. To this end, high-resolution biexponential analysis was used to permit measurement and assignment of two samples with a single radio frequency detection coil. This approach was used to calibrate and expand the dynamic range of MRSw biosensors in a single step. The potential for easy-to-use MRSw-based diagnostics was demonstrated by combining the method for single-step measurement of two samples with a disposable, plastic cartridge and dried MRSw reagents to obtain a calibrated reading after only two steps: mix and read. Taken together, our results suggest the feasibility of developing magnetic resonance based in vitro diagnostics that offer extreme ease of use and simple instrumentation.
Single-crystalline CoFe nanoparticles encapsulated in N-doped carbon nanotubes as a bifunctional catalyst for water splitting (2020)

We utilize a simple heat-treatment process to synthesize single-crystalline CoFe alloy nanoparticles encapsulated in N-doped carbon nanotubes, which exhibit excellent catalytic activity and superior stability towards overall water splitting.
Metabolic phenotypes and incident type 2 diabetes: Population‐based Panasonic cohort study 6 (2022)

This study demonstrates that it is important to pay attention to the changes in metabolic phenotypes to prevent incident type 2 diabetes in Japanese populations.
The Reaction of Low Molecular Weight Silicic Acids with Molybdic Acid (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Reaction of Low Molecular Weight Silicic Acids with Molybdic AcidG. B. AlexanderCite this: J. Am. Chem. Soc. 1953, 75, 22, 5655–5657Publication Date (Print):November 1, 1953Publication History Published online1 May 2002Published inissue 1 November 1953https://doi.org/10.1021/ja01118a054Request reuse permissionsArticle Views703Altmetric-Citations109LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (419 KB) Get e-Alertsclose Get e-Alerts
Adaptive advantage of oligopetide transporters acquired by horizontal transfer during wine fermentation (2015)

Adaptive advantage of oligopetide transporters acquired by horizontal transfer during wine fermentation. 10. Symposium International d’Œnologie de Bordeaux, Œno2015
Utilization of a Soluble Integrin-Alkaline Phosphatase Chimera To Characterize Integrin α8β1 Receptor Interactions with Tenascin:  Murine α8β1 Binds to the RGD Site in Tenascin-C Fragments, but Not to Native Tenascin-C (1998)

The integrin alpha 8 beta 1 has been reported to bind to fibronectin, vitronectin, and tenascin-C in cell adhesion or neurite outgrowth assays. Here, we describe cDNA cloning of the murine alpha 8 subunit, purification of a recombinant soluble heterodimer consisting of the extracellular domains of the murine alpha 8 and beta1 subunits, and development of a sensitive binding assay using a modified form of this heterodimer fused to alkaline phosphatase (AP). In binding assays, the purified alpha 8 beta 1-AP chimera exhibited the same divalent ion requirements for activation and binding specificity as cell surface alpha 8 beta 1: in the presence of Mn2+ it bound to fibronectin and vitronectin in an RGDS-peptide inhibitable manner. Contrary to previous reports, we found no evidence that alpha 8 beta 1, expressed on K562 cells or as an AP chimera, interacts strongly with native tenascin-C. In binding, adhesion, and spreading assays, significant interactions were observed only to short fragments of tenascin-C containing the third fibronectin type III repeat which contains an RGD sequence. Full length tenascin-C and longer fragments containing this repeat did not appear to serve as ligands, implying that the RGD site in native tenascin-C is a cryptic binding site for this integrin, exposed by removal of adjacent domains. Soluble integrin-AP chimeras should be generally useful for identifying and characterizing integrin interactions with ligands.
Effects of transcutaneous electrical nerve stimulation on physical symptoms in advanced cancer patients receiving palliative care (2019)

Transcutaneous electrical nerve stimulation (TENS) is primarily used for pain, but might be useful for various other physical symptoms, including nausea, fatigue, dyspnea, and constipation. However, few studies have used TENS for treating the physical symptoms of patients with advanced cancer. In this crossover trial, we assess the effects of TENS on pain and other physical symptoms in 20 in-patients with advanced cancer receiving palliative care. For 5-day phases between wash out periods of 5 days, patients received TENS or non-TENS. TENS was delivered at four points: the center of the back for mainly nausea and dyspnea, on the back at the same dermatomal level as the origin of the pain (100 Hz), and on both ankle joints for constipation (10 Hz). The intensity of pain and the total opioid dose used during phases were recorded. Physical symptoms were evaluated using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 15 Palliative Care (QLQ-C15-PAL). Hematological and biochemical data were recorded before and after the TENS phase. The average pain and total number of opioid rescue doses were significantly reduced by TENS. TENS tended to improve nausea and appetite loss, but not constipation. There were no effects on hematological and biochemical parameters. Use of TENS could safely improve pain, nausea, and appetite loss in patients with advanced cancer. Although it cannot be used as a substitute for opioids and other pharmaceutical treatment, it may be useful to support palliative care.
Across the Board: Pieter Bruijnincx (2016)

In this series of articles, the board members of ChemSusChem discuss recent research articles that they consider of exceptional quality and importance for sustainability. This entry features Dr. Pieter Bruijnincx, who discusses bio-based approaches to new and existing chemicals for large-scale polymer applications, highlighting that the development of methodologies to obtain key monomers from biomass leads to new chemistry, aids the transition to a more sustainable chemical industry, and fosters new interdisciplinary approaches.
Efficacy of Divalproex vs Lithium and Placebo in the Treatment of Mania (1994)

Both divalproex and lithium were significantly more effective than placebo in reducing the symptoms of acute mania. The efficacy of divalproex appears to be independent of prior responsiveness to lithium.
An Algorithm about Transforming PLC Ladder Diagram to Instruction List Based on Series-Parallel Merging Method (2008)

Usually there are 3 steps in transforming PLC ladder diagram to instruction list: including mapping ladder diagram to AOV digraph, transforming AOV digraph to binary trees and transforming binary trees into instruction list. The second step is the most critical and complicated. This paper proposes a method that can transform the AOV digraph to binary trees by using Series-parallel Merging thought, which is visual and easy to realize. An example of transformation is given, which introduced the algorithm and transforming steps.
New Techniques to Express and Crystallize G Protein‐Coupled Receptors (2010)

This chapter contains sections titled: Introduction Key Problems Limiting Production of 3D GPCR Structures History of GPCR Structures The Search for Other GPCR Structures Protein Purification and Solubilization In Cubo Crystallization Engineering Receptor Stability Structures of the β2AR The Adenosine A2a Receptor Conclusions and Future Developments Acknowledgments References
Practical Application of CFP Technology to Resolve Complex Near Surface Problems and to Estimate a Velocity-depth Model (2009)

Complex topography and highly variable weathering layers in the near surface can severely degrade the quality of seismic data and result in a distorted structural image of the subsurface reflectors. One objective of this work is to compare seismic image q
ChemInform Abstract: CHEMISTRY OF SULFONYL CYANIDES PART 4, DIELS‐ALDER CYCLOADDITIONS OF SULFONYL CYAMIDES WITH DIENES (1974)

Abstract Bei der Reaktion der entsprechenden Sulfonylcyanide (I) mit den Butadienen (II) werden unter milden Bedingungen (20‐72°C) über in situ gebildete Diels‐Alder‐Addukte die Pyridine (III) und die Pyridone (IV) erhalten.
Computer-Aided Deduction of Mass Spectra Detected on a Photographic Plate.III.Background and Sample Background(Undesired Components in a Mixture)Subtraction (1974)

The procedure by which the peaks arising from the background can be checked and subtracted has been reported. The mass spectra of the background and sample were detected in separate runs of the plate under controlled conditions, and were stored in separate dimensions in a computer. The checks and subtractions were carried out on the basis of difference in exact masses and of the ratio of intensities. A similar procedure was also be applied to the checks and subtractions of the reactants(sample background)in a reaction mixture to afford only a spectrum of the species produced by the reaction. The subtractions of the background and sample background were examined for a mixture of benzophenone(I), 2, 4-dinitrophenylhydrazine(II)and2, 4-dinitrophenylhydrazone of I being taken I and II as sample backgrounds. The utility and limitation of the procedure have been described and discussed.
Why RTS-CTS is not your ideal wireless LAN multiple access protocol (2005)

Although request-to-send clear-to-send (RTS-CTS) has been introduced as a uniform improvement over carrier sense multiple access (CSMA) in a wireless LAN environment, it is not. As it tries to solve the hidden-stations problem of CSMA, it creates new problems derived from the interaction among its control and data packets. We systematically identify and classify the sequences of events where CSMA and RTS-CTS depart from an ideal behavior, and we define a reference configuration and an analytical model on the basis of which a comparative study of protocol performance is made. The results show that RTS-CTS falls short of an ideal protocol, in some cases performing even worse than CSMA. This is especially noticeable in situations where the interaction between control packets in RTS-CTS prevents transmissions that under CSMA could occur concurrently and successfully.
Querying physicians' beliefs in career choice studies: the limitations of introspective causal reports. (1993)

Numerous studies in family medicine literature explore the determinants of physicians' specialty and practice location choices. A research approach frequently used in these studies has been to ask study physicians what led them to make specific career choices, labeled here as the introspective causal reports study design. This paper explores the validity of introspective causal reports and their usefulness in making health manpower policy recommendations. The accuracy of people's beliefs about the causes of their own behaviors is examined, and social psychology literature is drawn upon in this examination. Data are presented characterizing the use of introspective causal reports in recent family medicine literature. Recommendations are made for stronger research designs in future physician career choice determinant studies.
Crystal structure of GeI4 at 100 K and 297 K (1993)

Abstract The crystal structure of GeI 4 was refined using 100 K and 297 K X-ray data. GeI 4 crystallizes in the cubic space group P 2 1 / a [unk] (No 205) with a = 11.861(1) Å at 100 K and 12.0303(6) Å at 297 K. Analysis of the displacement parameters gives no hint for rigid body motion.
Nucleation and annihilation of magnetic vortices in sub-micron permalloy dots (2001)

The magnetization reversal processes in Fe/sub 20/Ni/sub 80/ dot arrays have been studied both experimentally and theoretically. The circular-shaped dots with thickness of 60 nm and variable diameters of 0.2-0.8 /spl mu/m were fabricated by using electron-beam lithography and lift-off technique. A size dependent vortex nucleation, annihilation and initial susceptibility were determined from magneto-optical hysteresis loops. With increasing dot diameter the nucleation and annihilation fields decrease, whereas the initial susceptibility exhibits a linear increase. The experimental data were compared to the results of analytical calculations taking into account magnetostatic interactions, exchange and Zeeman energies for a planar array of magnetically soft circular dots.
Supplementary Figure 4 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth (2023)

&lt;p&gt;PDF file - 252K, Effect of Pyr1 on NEK11 and MLK1 activity&lt;/p&gt;
Improvement of electrochemical performance of rechargeable lithium–selenium batteries by inserting a free-standing carbon interlayer (2014)

A simple, low-cost modification of lithium–selenium (Li–Se) cells by placing a carbon interlayer between the selenium electrode and the separator has been investigated to significantly improve the electrochemical performance of Li–Se cells.
Reduction in Gram-positive pneumonia and antibiotic consumption following the use of a SDD protocol including nasal and oral mupirocin (2001)

The objective of this prospective, randomized, double-blind study was to evaluate the effect of the addition of mupirocin to the 'classical' topical SDD regimen (tobramycin 80 mg, polymyxin E 100 mg, amphotericin B 500 mg) on the development of ICU-acquired infections due to gram-positive bacteria. The study was carried out in an intensive care unit (ICU) of a 1400-bed community hospital. All patients admitted to the ICU during a 16-month period, who were expected to require mechanical ventilation for more than 24 hours, were randomized to receive either the 'classical' SDD regimen (Group A) or a modified regimen with mupirocin (Group B). Data from 223 patients requiring mechanical ventilation for at least 48 hours, who were neither infected nor receiving antibiotics on ICU admission, was analysed. A 2% paste containing tobramycin, polymyxin E and amphotericin B was applied every 6 hours in the oropharynx to the patients in Group A, while in Group B this formula was modified with the addition of 2% mupirocin. In Group B 0.2 ml of a 2% mupirocin ointment was also applied four times daily in both nostrils. Patients in Group A received a soft paraffin ointment as a placebo indistinguishable from mupirocin. Patients in both groups received the classic SDD regimen through the nasogastric tube. Systemic antibiotic prophylaxis was not used. Data on lower airway infection, and blood infection, infections of intravascular catheters, antibiotic consumption and expenditures for antibiotics were analysed. The diagnosis of ventilator-associated pneumonia (VAP) was based on quantitative cultures of protected specimen brush samples (PSB) or on the results of distal broncho-alveolar lavage (BAL). One hundred and four patients received the 'classical' SDD and 119 the modified regimen. Overall 29 patients, 20 in Group A and nine in Group B (p < 0.02) had a total of 33 cases of pneumonia. There were 23 episodes of pneumonia in Group A and 10 in Group B (p < 0.02). Gram-positive bacteria were isolated from samples in 17 episodes in Group A and six in Group B (p < 0.02). Staphylococcus aureus was isolated in nine cases of pneumonia in Group A and once in the 'mupirocin' group (p < 0.05). MRSA were isolated in seven out of nine cases in Group A and in the only case in Group B. There were no differences in the isolation of gram-negative bacilli. Antibiotic consumption and cost were lower in Group B. In conclusion, our data show that the topical use of a modified formula of SDD, with the addition of mupirocin to the oral paste and in the anterior nares, is associated with a reduction in lung infections caused by gram-positives and in a reduction in antibiotic consumption and in the overall expenditure for antibiotics.
Comparison of Physicochemical Properties of Korean and Chinese Red Bean Starches (2003)

The physicochemical properties of starches from Korean and Chinese red bean were investigated. Korean red bean starch (KRBS) contained lower water content, but higher crude fat and carbohydrate content than those of Chinese red bean starch (CRBS). The round shape of starch granules from Korean and Chinese red bean was observed. The granule size of KRBS was smaller than that of CRBS. The whiteness of KRBS (87.22%) was significantly higher than that (86.16%) of CBRS. X-ray diffraction patterns between KRBS and CRBS were not significantly different, resulting in showing C type. There was significant difference in amylose content between KRBS and CRBS. The blue value of KRBS was 1.02, which was higher than that of CRBS. Swelling power of KRBS was higher up to than that of CRBS, but then decreased. Solubility showed the same pattern as the swelling power. Our findings suggest that Korean red bean has better quality than Chinese red bean in terms of the physicochemical properties.
Simulation‐Based Optimization I: Regeneration, Common Random Numbers, and Selection Methods (2003)

This chapter includes the following topics: Background Regenerative Systems Optimization with Finite-Difference and Simultaneous Perturbation Gradient Estimators Common Random Numbers Selection Methods for Optimization with Discrete-Valued θ Concluding Remarks