gebhart/patrepeval huggingface dataset:
Updating a Synchronous Fluorescence Spectroscopic Virgin Olive Oil Adulteration Calibration to a New Geographical Region (2011)

Detecting and quantifying extra virgin olive adulteration is of great importance to the olive oil industry. Many spectroscopic methods in conjunction with multivariate analysis have been used to solve these issues. However, successes to date are limited as calibration models are built to a specific set of geographical regions, growing seasons, cultivars, and oil extraction methods (the composite primary condition). Samples from new geographical regions, growing seasons, etc. (secondary conditions) are not always correctly predicted by the primary model due to different olive oil and/or adulterant compositions stemming from secondary conditions not matching the primary conditions. Three Tikhonov regularization (TR) variants are used in this paper to allow adulterant (sunflower oil) concentration predictions in samples from geographical regions not part of the original primary calibration domain. Of the three TR variants, ridge regression with an additional 2-norm penalty provides the smallest validation sample prediction errors. Although the paper reports on using TR for model updating to predict adulterant oil concentration, the methods should also be applicable to updating models distinguishing adulterated samples from pure extra virgin olive oil. Additionally, the approaches are general and can be used with other spectroscopic methods and adulterants as well as with other agriculture products.
An Arduino based heartbeat detection device (ArdMob-ECG) for real-time ECG analysis (2022)

This technical paper provides a tutorial to build a low-cost (10-100 USD) and easy to assemble ECG device (ArdMob-ECG) that can be easily used for a variety of different scientific studies. The advantage of this device is that it automatically stores the data and has a built-in detection algorithm for heartbeats. Compared to a clinical ECG, this device entails a serial interface that can send triggers via USB directly to a computer and software (e.g. Unity, Matlab) with minimal delay due to its architecture. Its software and hardware is open-source and publicly available. The performance of the device regarding sensitivity and specificity is comparable to a professional clinical ECG and is assessed in this paper. Due to the open-source software, a variety of different research questions and individual alterations can be adapted using this ECG. The code as well as the circuit is publicly available and accessible for everyone to promote a better health system in remote areas, Open Science, and to boost scientific progress and the development of new paradigms that ultimately foster innovation.
Large-amplitude flapping of an inverted flag in a uniform steady flow – a vortex-induced vibration (2016)

The dynamics of a cantilevered elastic sheet, with a uniform steady flow impinging on its clamped end, have been studied widely and provide insight into the stability of flags and biological phenomena. Recent measurements by Kim et al. ( J. Fluid Mech. , vol. 736, 2013, R1) show that reversing the sheet’s orientation, with the flow impinging on its free edge, dramatically alters its dynamics. In contrast to the conventional flag, which exhibits (small-amplitude) flutter above a critical flow speed, the inverted flag displays large-amplitude flapping over a finite band of flow speeds. The physical mechanisms giving rise to this flapping phenomenon are currently unknown. In this article, we use a combination of mathematical theory, scaling analysis and measurement to establish that this large-amplitude flapping motion is a vortex-induced vibration. Onset of flapping is shown mathematically to be due to divergence instability, verifying previous speculation based on a two-point measurement. Reducing the sheet’s aspect ratio (height/length) increases the critical flow speed for divergence and ultimately eliminates flapping. The flapping motion is associated with a separated flow – detailed measurements and scaling analysis show that it exhibits the required features of a vortex-induced vibration. Flapping is found to be periodic predominantly, with a transition to chaos as flow speed increases. Cessation of flapping occurs at higher speeds – increased damping reduces the flow speed range where flapping is observed, as required. These findings have implications for leaf motion and other biological processes, such as the dynamics of hair follicles, because they also can present an inverted-flag configuration.
Advanced Transceiver Design Study. (1976)

An advanced transceiver design concept is described which outlines the process required for developing a spread spectrum adaptive processing transceiver capable of meeting the ECM threat. The design relies on the optimal integration of pseudo-noise band spreading techniques and adaptive cancellation scheme to achieve greater than 60 dB of anti-jam performance. Basic to the concept is the development of signal estimates and tracking algorithms to correctly control the PN code and the phase and amplitude of the received signals by an adaptive array. The theoretical basis for interconnecting spatial and temporal processors in a single, optimal space - time processor is presented. Appropriate simplifications in the theoretical optimum transceiver processing system are made in order to derive a realistic transceiver baseline architecture. For the baseline system, a paper design was synthesized. Implementation approaches considered were an all-digital approach and an analog approach for the highly adaptive processing subassemblies consisting of an adaptive array, colored noise filter, adaptive matched filter, and signal estimator.
Why You Should Not Play the Numbers Game with Anti-Spyware Vendors (2006)

Abstract Security technology vendors relish throwing out numbers: We have “X” more pattern files or “Y” more algorithms than any other vendor. We have more >>fill in this blank with your most-often- heard sales pitch<< to make you more secure.
Human plasminogen activator inhibitor-1 gene. Promoter and structural gene nucleotide sequences. (1988)

We have determined the nucleotide sequence of the human plasminogen activator inhibitor-1 (PAI-1) gene and significant stretches of DNA which extend into its 5'-and 3'-flanking DNA regions; a total sequence of 15,867 base pairs (bp) is presented. The sequenced 5'-flanking DNA (1,520 bp) contains the essential eukaryotic cis-type proximal regulatory elements CCAAT and TATAA; the more distal 5'-flanking DNA region, as well as some introns, contain sequence elements which share identities with known eukaryotic enhancer elements. A major finding is the identification of a large region of shared nucleotides (comprising of about 520 bp) between the 5'-flanking DNAs of PAI-1 and tissue-type plasminogen activator genes. The length of the PAI-1 5'-untranslated region was found to be 145 bp as determined by nuclease analysis. The remaining PAI-1 structural gene consists of amino acid coding regions (containing a total of 1,206 bp, coding for the 23 amino acids of the signal peptide and 379 amino acids of the mature PAI-1 protein), 8 intron regions (a total of 8,978 bp), and a long 3'-untranslated region of about 1,800 bp which contains several polyadenylation sites. Two types of repetitive DNA elements are located within the PAI-1 structural gene and flanking DNAs: we have found 12 Alu elements and 5 repeats of a long poly (Pur) element. These Alu-Pur elements may represent a subset of the more abundant Alu family of repetitive sequence elements.
Pan-ebolavirus serology study of healthcare workers in the Mbandaka Health Region, Democratic Republic of the Congo (2022)

Although multiple antigenically distinct ebolavirus species can cause human disease, previous serosurveys focused on only Zaire ebolavirus (EBOV). Thus, the extent of reactivity or exposure to other ebolaviruses, and which sociodemographic factors are linked to this seroreactivity, are unclear. We conducted a serosurvey of 539 healthcare workers (HCW) in Mbandaka, Democratic Republic of the Congo, using ELISA-based analysis of serum IgG against EBOV, Sudan ebolavirus (SUDV) and Bundibugyo ebolavirus (BDBV) glycoproteins (GP). We compared seroreactivity to risk factors for viral exposure using univariate and multivariable logistic regression. Seroreactivity against different GPs ranged from 2.2-4.6%. Samples from six individuals reacted to all three species of ebolavirus and 27 samples showed a species-specific IgG response. We find that community health volunteers are more likely to be seroreactive against each antigen than nurses, and in general, that HCWs with indirect patient contact have higher anti-EBOV GP IgG levels than those with direct contact. Seroreactivity against ebolavirus GP may be associated with positions that offer less occupational training and access to PPE. Those individuals with broadly reactive responses may have had multiple ebolavirus exposures or developed cross-reactive antibodies. In contrast, those individuals with species-specific BDBV or SUDV GP seroreactivity may have been exposed to an ebolavirus not previously known to circulate in the region.
Etude de la recombinaison chez les Cucumovirus (2004)

La recombinaison entre genomes viraux est un processus qui participe a la conservation et l’evolution du genome viral. L’objet du travail presente dans cette these etait de detecter l’apparition de molecules recombinantes entre deux cucumovirus, le virus de la mosaique du concombre (CMV) et le virus de l’aspermie de la tomate (TAV). Au cours d’une coinfection sur des plants de tabac, nous avons pu identifier par RT-PCR des molecules recombinantes dans la region 3’ non codante de l’ARN 3 de ces virus. L’observation des differents sites de recombinaison nous a permis d’identifier deux points chauds de recombinaison. L’un d’eux etait situe au niveau du promoteur de synthese du brin negatif, dans une region qui a souvent ete impliquee dans la recombinaison. Le second etait situe dans une region impliquee dans la generation de l’ARN 5 subgenomique. Il a ete propose que l’ARN 5 soit genere par une reconnaissance d’un promoteur subgenomique putatif. Il etait ensuite interessant de savoir si l’apparition de molecules recombinantes pouvait avoir un impact sur le developpement de l’infection virale. Cette question a ete adressee par l’etude des proprietes biologiques de virus possedant un ARN 3 recombine. Lorsque les virus recombinants ont ete inocules seuls sur les deux plantes hotes utilisees, le tabac et l’arabette, aucun symptome particulier n’a ete developpe. Il etait interessant de constater que ces virus avaient ete generes de facon detectable au cours d’une coinfection, et qu’ils etaient capables d’infecter de facon efficace les hotes testes. Leur impact au niveau de la population virale pourrait acquerir une importance dans le cas d’infection sur d’autres plantes hotes.
Nondegenerate Surface-Wave Mode Coupling Between Dielectric Waveguides (1975)

A new variational derivation of the coupling coefficient is given for the problem of nondegenerate surface-wave modes on parallel dielectric waveguides. The results coincide with those of a number of different methods in the literature on the degenerate case, but all give distinct results in the nondegenerate case. These differences are examined and compared with the exact solution, whereby the approximations involved can be evaluated for the case of two parallel slab waveguides.
Plant Terpenoids: Biosynthesis and Ecological Functions (2007)

Abstract Among plant secondary metabolites terpenoids are a structurally most diverse group; they function as phytoalex‐ins in plant direct defense, or as signals in indirect defense responses which involves herbivores and their natural enemies. In recent years, more and more attention has been paid to the investigation of the ecological role of plant terpenoids. The biosynthesis pathways of monoterpenes, sesquiterpenes, and diterpenes include the synthesis of C5 precursor isopentenyl diphosphate (IPP) and its allylic isomer dimethylallyl diphosphate (DMAPP), the synthesis of the immediate diphosphate precursors, and the formation of the diverse terpenoids. Terpene synthases (TPSs) play a key role in volatile terpene synthesis. By expression of the TPS genes, significant achievements have been made on metabolic engineering to increase terpenoid production. This review mainly summarizes the recent research progress in elucidating the ecological role of terpenoids and characterization of the enzymes involved in the terpenoid biosynthesis. Spatial and temporal regulations of terpenoids metabolism are also discussed.
Abstract P211: Association Between Urbanization-related Change in Diet, the Gut Microbiota and Microbiome-related Metabolites in a Rapidly Urbanizing Environment in China (2020)

Introduction: Numerous studies suggest that there are rural-urban differences in gut microbial community, partially due the Westernization of diet. However, most studies are based on short-term follow-up and cannot assess how the transition from traditional to Western diets over time shapes human gut microbiota and whether these microbiota changes subsequently impact the metabolomic profile of the host. Hypothesis: We hypothesize that trajectories in diet shape components of the gut microbial community, with strong associations for microbiota and microbiome-mediated metabolites. Methods: We used growth mixture models to estimate individual-specific intercepts (current % calories from animal source food in 2015) and slopes (change in % calories from animal source food from 1991-2015) in 1,468 adults from the population-based China Health and Nutrition Survey (CHNS) across 20 years of urbanization-related change. We then tested the association between the gut microbiota genera in 2015 with these intercepts and slopes in linear regression models, allowing for interactions between the intercepts and slopes. In the subset of the sample with metabolomic measures collected (n = 500), we then tested whether bacteria associated with change in diet (FDR corrected p-values &lt; 0.05 from the joint test of both main effect and interaction) were associated with microbiome-related metabolites using linear regression models. Results: Controlling for current % calories from animal source food, we found 57 gut microbiota measures that were significantly associated with the rate of change in % animal source calories, with the majority (19%) coming from the order Clostridiales. For 55 gut microbiota measures, we found evidence that the association between current diet and gut microbiota was modified by the rate of change in diet. Thirty-two microbiome-related metabolites, over 50% of which were involved in the benzoate metabolism or food component pathways, were associated with these gut microbiota measures. Conclusions: Our findings suggest that long-term change in calories consumed from animal source foods may shape the composition of the gut microbial community. Further, our metabolome findings suggest that pathways linking diet and the microbiome through microbial metabolites may be particularly relevant.
Congestive Heart Failure Update: New Cardiac Peptides in Diagnosis and Treatment (2004)

ABSTRACT: The Studies of Left Ventricular Dysfunction (SOLVD) trials demonstrated that early intervention in congestive heart failure (CHF) improves survival. However, early CHF is mainly a clinical diagnosis based on New York Heart Association criteria and, until recently, no easy and inexpensive screening test existed. There are now several such tests that employ radioimmunoassays (RIAs) to measure cardiac peptides in a single plasma sample; results help determine the likelihood that CHF is present but do not definitively establish the diagnosis. The vessel dilator RIA is the most specific and sensitive for differentiating persons with mild CHF from healthy ones; intravenous administration of this cardiac peptide hormone has beneficial hemodynamic, diuretic, and natriuretic properties in persons who have CHF. Brain natriuretic peptide (BNP) measured by fluorescence immunoassay is useful in the emergency department, because a result may be obtained in as little as 15 minutes. This assay may indicate CHF; further tests are recommended to define the diagnosis. BNP increases with other causes of dyspnea, including pulmonary hypertension, pulmonary emboli, and renal failure, so it is not specific for CHF. BNP also increases with age, and measured values are higher in women than in men.
The universal approximation power of finite-width deep ReLU networks (2018)

We show that finite-width deep ReLU neural networks yield rate-distortion optimal approximation (Bölcskei et al., 2018) of polynomials, windowed sinusoidal functions, one-dimensional oscillatory textures, and the Weierstrass function, a fractal function which is continuous but nowhere differentiable. Together with their recently established universal approximation property of affine function systems (Bölcskei et al., 2018), this shows that deep neural networks approximate vastly different signal structures generated by the affine group, the Weyl-Heisenberg group, or through warping, and even certain fractals, all with approximation error decaying exponentially in the number of neurons. We also prove that in the approximation of sufficiently smooth functions finite-width deep networks require strictly smaller connectivity than finite-depth wide networks.
Evidence of self-inhibition by filamentous fungi accounts for unidirectional hyphal growth in colonies (1998)

Hyphal growth in filamentous fungi proceeds in an unidirectional radial pattern from a point inoculation. An inhibitor produced, secreted, and absorbed by the advancing hyphae has been speculated to account for directional growth. Working with Mucor and Aspergillus, laboratory evidence is provided for the production of an inhibitory by the advancing hyphae of these filmentous fungi that precludes back growth. Strains of Mucor and Aspergillus inoculated in agar on a 0.45-mm membrane filter placed on agar surfaces grow radially beyond the filter perimeter and onto the agar surface. Removal of the filter pad does not result in hyphal extension back into the clear zone underlying the membrane filter. Inoculation of the clear zone with a fresh Mucor or Aspergillus spore suspension does not result in hyphal growth. Instead, germinating spores show aberrant and aborted hyphae. The fungal inhibitor shows cross-reactivity between Mucor and Aspergillus, is resistant to pronase (10 mg/mL) but not chloroform inactivation, and passes through dialysis tubing with a molecular weight cutoff of 3500.
<title>X-ray generation from Nd laser-irradiated gas puff targets</title> (1994)

This paper reports the first experimental investigations of soft x-ray generation from Nd laser- irradiated gas puff targets. The gas puff targets were made by the pulsed injection of gas (SF<SUB>6</SUB> or Kr) into a vacuum chamber. To irradiate the gas puff targets a Nd-glass laser was used, which generated 1-ns pulses of up to 15 J in energy. The gas flow was initiated by a fast solenoid valve synchronized with a laser pulse. Spatial, spectral and temporal measurements show that intense soft x-ray emission from the laser-irradiated gas puff targets is produced. Using the presented technique one can obtain a new type of a laser plasma x-ray source (LPXS), which has some advantages over LPXS with a solid target, such as reproducibility of target conditions and no sputtering by target debris produced in the laser plasma.
Structural transitions in bovine factor X associated with metal binding and zymogen activation. Studies using conformation-specific antibodies. (1982)

Conformation-specific antibodies against distinct regions of Factor X were employed to locate antigenic determinants which are altered during zymogen activation or by metal binding. Anti-Factor X antibodies, raised in rabbits against Factor X, were purified by affinity chromatography using Factor X covalently bound to Sepharose. Quantitative equilibrium and kinetic measurements of precipitation of Factor X and Factor Xa by antibodies indicated differences in the antigenic structure of the zymogen and the enzyme form of factor X. The factor X antibodies were further fractionated by sequential immunoabsorption using fragments of Factor X and Factor Xa. With conformation-specific antibodies directed against the heavy chain and the light chain of Factor X, zymogen activation was shown to involve a structural transition in the heavy chain but not the light chain. Antibodies directed against the activation peptide domain 1-51 of the heavy chain, the trypsin-like region of the heavy chain 52-290, and the substrate-binding site suggest a generalized conformational transition in the heavy chain. Antibodies were isolated which are specific for the Factor X:Ca(II) complex and bind to Factor X only in the presence of metal ions. Subfractions were directed against either the heavy chain or the light chain, indicating that both the heavy chain and the light chain of Factor X undergo a metal-induced conformational transition. Half-maximal antibody-factor X interaction was observed at 0.13 mM CaCl2 for the light chain and 0.7 mM CaCl2 for the heavy chain. These results indicate that zymogen activation is limited to structural changes in the heavy chain, but metal binding is associated with changes in the structure of both the heavy and light chains. Metal-dependent binding of Factor X to the platelet Factor Xa receptor after activation may involve surfaces of the heavy as well as the light chains.
High Efficient Interleaved Multi-channel dc/dc Converter Dedicated to Mobile Applications (2006)

In the transportation field, the empty weight of the vehicle has to be as light as possible in order to have the highest energetic efficiency. For onboard storage electrical systems, DC/DC converters are usually used to control the power flows in the vehicle. This paper focuses on two different DC/DC converter applications: high current/low voltage on the one hand and low current/high voltage on the other hand. For all power mobile applications, a standard dc/dc converter is not realizable due to mass and volume constraints. As the inductor is usually the biggest and heaviest component in the system, it is important to develop a new structure allowing the reduction of its size and weight. The chosen technology is based on interleaved channels operating in discontinuous mode, also using reverse conduction of power MOSFET transistors. For both of the cases described above, a prototype has been built composed of 8 and 4 channels respectively. The first converter is used for power assistance (250 A/18 V) using the MOS reverse conduction property. In this particular case, efficiency is up to 96.3 %. The second is developed for a mobile solar application (3.8 A/270 V). Efficiencies are up to 98.4 %