gebhart/patrepeval huggingface dataset:
Effect of Hochuekkito on Alveolar Macrophage Inflammatory Responses in Hyperglycemic Mice (2012)

Diabetes mellitus reduces immunological activity and increases susceptibility to various infections. Hochuekkito (TJ-41) has been reported to improve the weakened physical condition of various chronic diseases. BALB/c mice were divided into three groups; groups A and B were fed a standard diet, and group C, a TJ-41 diet. Two weeks after starting these diets, hyperglycemia was induced in groups B and C by injection with streptozotocin. Two weeks later, bronchoalveolar lavage was performed. Toll-like receptor (TLR) ligands (TLR2: peptidoglycan, PGN; TLR4: lipopolysaccharide, LPS; TLR5: flagellin, FLG) were used to stimulate alveolar macrophages (AMs), and TNF-α production was measured. Under hyperglycemic conditions and PGN or FLG stimulation, TNF-α production from AMs was significantly reduced in group B compared with group A. However, treatment with TJ-41 (group C) significantly improved the impaired production of TNF-α. These results suggest that, under hyperglycemic conditions, TJ-41 can improve the inflammatory responses of AMs with stimulation of TLR ligands.
Endothelial follicle-stimulating hormone receptor expression in invasive breast cancer and vascular remodeling at tumor periphery (2015)

Endothelial FSHR expression in breast cancer is associated with vascular remodeling at tumor periphery.
Postharvest Decay Risk Associated with Hydrocooling Tomatoes (2000)

Tomatoes (breaker stage) hydrocooled with a cell suspension of Erwinia carotovora subsp. carotovora containing 50 to 200 mg of free chlorine per liter (ppm) (10°C, pH 7) remained decay free during a 10-day storage at 20°C. Sporadic disease appeared during storage of tomatoes similarly cooled with chlorinated water containing spores of Rhizopus stolonifer. In contrast, when chlorine was omitted from the pathogen suspensions, 50 to 100% of the fruit became diseased. A laboratory-scale shower hydrocooler reduced fruit temperatures from 35 to 15°C within 13.3 min, whereas a flume cooler produced the same temperature reduction in 10.5 min. In both systems, tomatoes increased in weight during cooling, evidence for water uptake. Larger weight increases occurred among tomatoes cooled in the shower than in the flume. An upward instead of downward orientation of stem scars under the shower streams led to significantly larger weight increases, presumably because pores in the stem scar were continuously flooded with water. Tomatoes intermittently submerged in cold water (10 2-min immersions followed by 30-s pauses) absorbed significantly less water than those continuously submerged for 20 min. Hydrocooling appears to be a viable method for rapid cooling of tomatoes. Technical refinements in the hydrocooling process that prevent continuous coverage of fruit surfaces by water should reduce water uptake and the associated risk of pathogen internalization. Maintenance of free chlorine at up to 200 ppm in the cooling water and prevention of direct water pressure on fruit should minimize decay risks. No evidence of phytotoxicity was observed among fruit infiltrated with 200 ppm of chlorine. These tomatoes ripened similarly to those that were not cooled or were cooled in tap water.
Multilayered epoxy/glass fiber felt composites with excellently acoustical and thermal insulation properties (2018)

ABSTRACT In this article, a series of epoxy composites consisting of multilayered ultra‐fine glass fiber felts (GFFs) were produced by a hand lay‐up process. The incorporation of GFFs greatly enhances the sound‐absorption and sound‐insulation properties of epoxy composites. It can be mainly attributed to great numbers of voids introduced into the matrix and the increasing interfacial area between glass fiber and epoxy resin, which is confirmed by scanning electron microscopy results. Furthermore, the thermal insulation performance of epoxy/glass fiber felt (EP/GFF) composites is continuously improved with the growing GFF layer, and meanwhile EP/GFF composites exhibit the satisfactory mechanical property. Such novel EP/GFF composites can serve as promising structural, heat‐insulated, and soundproof materials in many multifunctional systems including buildings, aircrafts, constructions, vehicles, etc. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 46935.
Agonist-dependent Phosphorylation and Desensitization of the Rat A3 Adenosine Receptor (1995)

A3 adenosine receptor (A3AR) activation contributes to both the cardioprotective and antihypertensive effects of adenosine. To date, no studies have examined the mechanisms by which this receptor undergoes rapid homologous desensitization. Therefore, a functional hemagglutinin epitope-tagged A3AR has been stably expressed in Chinese hamster ovary cells, and its regulation by the AR agonist 5'-N-ethylcarboxamidoadenosine (NECA) has been studied. Cellular exposure to NECA induces rapid (t1/2 = approximately 1 min) A3AR phosphorylation on serine and threonine residues. This is associated with a functional desensitization and a 30-40% reduction in the number of high affinity agonist binding sites as determined by radioligand binding assays. Activation of second messenger-regulated kinases could not mimic the effect of NECA, suggesting a role for G-protein-coupled receptor kinases (GRKs). In vitro phosphorylation assays demonstrate that phosphorylation of agonist-occupied A3ARs is enhanced by GRK2 and that cellular pretreatment with NECA dramatically inhibits subsequent GRK2-mediated phosphorylation in vitro. Therefore, the A3AR is phosphorylated in situ by a kinase similar or identical to GRK2, and this may be involved in rapid functional desensitization of the A3AR.
MRNA-directed synthesis of catalytically active mouse beta-glucuronidase in Xenopus oocytes. (1977)

Catalytically active mouse beta-glucuronidase (beta-D-glucuronide glucuronosohydrolase, EC 3.2.1.31) is formed when Xenopus oocytes are injected with mouse RNA enriched for poly(A)-containing mRNA sequences. With the RNA from androgen-induced kidneys, the efficiency of translation is comparable to that of endogenous Xenopus messenger, and the fidelity of translation is high. Detection of glucuronidase messenger by formation of a catalytically active product is several orders of magnitude more sensitive than detection by incorporation of isotopically labeled amino acids. As well as providing a sensitive technique for examining the regulation of gene expression, the system makes available an opportunity to study the regulation of post-translational polypeptide processing of a lysosomal enzyme.
Abstract 965: Identification of KJ-Pyr-9 as a potent MYC inhibitor (2015)

Abstract We have identified a novel small-molecule inhibitor of MYC, KJ-Pyr-9, from a Kröhnke pyridine library. KJ-Pyr-9 functions as an inhibitor of MYC in biochemical assays, in cells and in xenograft experiments. In vitro, KJ-Pyr-9 binds to MYC as well as MYC-MAX dimers and can disrupt binding of MYC-MAX dimers with E-box DNA. In cells, MYC-MAX dimerization can be disrupted in cells as demonstrated by protein fragment complementation assays. KJ-PYR-9 disrupts the transcriptional targets of MYC. The P493-6 cell line has tetracycline regulatable MYC expression. For this cell line, the transcriptional targets of MYC can be readily observed upon the addition of 0.1 ug/mL doxycycline. Both doxycycline and KJ-PYR-9 negatively regulate MYC transcriptional signatures as determined by GSEA. The growth of a variety of different MYC-dependent cell lines are inhibited, including MYC translocated Burkitt's lymphoma cell lines expressing high levels of MYC as well as solid tumor cell lines expressing moderate amounts of MYC. In vivo, KJ-Pyr-9 effectively blocks the growth of a xenotransplant of MYC-amplified human cancer cells. Citation Format: Jonathan R. Hart, Klaus Bister, Kim D. Janda, Peter K. Vogt. Identification of KJ-Pyr-9 as a potent MYC inhibitor. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 965. doi:10.1158/1538-7445.AM2015-965
Changes in Coronary Perfusion after Occlusion of Coronary Arteries in Kawasaki Disease (2014)

The right coronary artery should be followed up carefully because of possible occlusion of new onset or changes in collaterals.
Low noise position sensitive detector for optical probe beam deflection measurements (1996)

We report the design of an optical position sensor that uses two discrete photodiodes electrically connected in parallel, with opposing polarities. A lens provides optical gain and restricts the acceptance angle of the detector. The response of the device to displacements of an optical spot is similar to that of a conventional bicell type position sensitive detector. However, the discrete photodiode design enables simpler electronic amplification with inherently less electrical noise than the bicell. Measurements by the sensor of the pointing noise of a focused helium–neon laser as a function of frequency demonstrate high sensitivity and suitability for optical probe beam deflection experiments.
Initial investigation of mathematical morphology for the digital extraction of the skeletal characteristics of trabecular bone. (1997)

Modification of the morphological filter enhanced the extraction of skeletal characteristics of trabecular bone. A morphological filter may be a useful adjunct in computer-aided structural analysis of bone.
Metal Complexes of Alizarin II—The Structure of Some Metal Complexes of Alizarin other than Turkey Red (1963)

The molecular structures of some complexes of alizarin have been established. It has been shown that all these compounds have the sane general type of structure and that they consist of a complex anion (a chelate of alizarin with a trivalent metal) with a uni‐, bi‐ or quadri‐valent metal cation. Before complex formation, salt formation of the alizarin molecule is necessary, because otherwise complex formation will be very slow.
Bioavailability of selenium from raw and cooked ground beef assessed in selenium-deficient Fischer rats. (1994)

The data suggest that bioavailability of Se from ground beef is greater than that from either selenite or selenate.
Maturation and Effects of In‐Utero Brain Ischemia on IL‐1 and IL‐6 Protein Expression in Ovine White Matter and Cerebral Cortex (2010)

We examined the effects of maturation and ischemia‐reperfusion (IR) injury on changes in IL‐1β and IL‐6 protein expression in the ovine brain. Ovine fetuses were studied after 30 min of bilateral carotid artery occlusion and 72 h of reperfusion. Fetal and maternal control groups had no ischemia. IL‐1β and IL‐6 protein expression was compared between cerebral cortex (CC) and white mater (WM) in the same study groups using Western immunoblot. IR resulted in a 26% decrease in IL‐1β in CC and a 173% increase in WM as compared to the control fetuses. IL‐1β was 34% higher in WM than CC after IR. IL‐6 expression did not change in CC or WM after ischemia. IL‐1β was 31% higher in maternal than fetal control CC and 61% higher in maternal than fetal control WM. IL‐1β was 59% higher in fetal control CC than WM and 25% higher in maternal CC than WM. IL‐6 expression was significantly higher in maternal CC as compared to fetal control; there were no differences between fetal control and maternal WM. However, IL‐6 was 36% higher in control fetal WM compared to CC. IR results in down regulation of IL‐1β expression in fetal CC and up regulation in WM, and does not affect IL‐6 expression in either region. There is a differential response between IL‐1β and IL‐6 after ischemia in fetal CC and WM. There are also regional differences in IL‐1β and IL‐6 expression in normal fetal and maternal brain.
SFBC MIMO-OFDM peak-to-average power ratio reduction by polyphase interleaving and inversion (2006)

Many PAPR reduction schemes have been proposed for OFDM systems. Among these, the signal scrambling methods such as the partial transmit sequences (PTS) (S. H. Muller, et al., 1997) and selective mapping (SLM) (R. W. Bauml, et al., 1996) are attractive as they obtain better PAPR property by modifying OFDM signals without distortion. These schemes can also be applied to a SFBC MIMO-OFDM system, which is advantageous for dispersive channels, in a straightforward way by performing signal scrambling on data sequence before it is distributed to the transmit antennas according to employed encoding scheme. Note however that in the case of PTS PAPR reduction in the time domain is not possible, which leads to prohibitively large complexity of such scheme. In this letter, we introduce more effective approach, the polyphase interleaving and inversion (PII) PAPR scheme and its reduced complexity version (RC-PII), which is designed to suppress peaks in SFBC-OFDM, transmit diversity.
Four-channel, long-wavelength transmitter arrays incorporating passive laser/singlemode-fiber alignment on silicon waferboard (2003)

Individually addressable, four-channel transmitter arrays operating at a wavelength of 1.3 mu m have been developed based on a hybrid optoelectronic integration approach called silicon waferboard. This approach uses micromachined silicon substrates as a platform for integration of electronic, optoelectronic, and optical components. It should lead toward the development of optical multichip modules. Silicon waferboard uses mechanical alignment features fabricated on the surface of a silicon chip to permit passive optical alignment of components such as lasers and optical fibers. The transmitter array comprises a four-channel InGaAsP-InP laser array that is passively aligned to four single-mode fibers held in V-grooves. The transmitter array also includes a four-channel GaAs MESFET driver array chip that provides high-speed drive currents to the individual lasers. The laser array, driver array, and optical fibers are all spaced on 350- mu m centers. which results ill a transmitter array that fits within a width of only 2 mm. Packages with high-speed electrical and optical I/Os have also been designed to accommodate the transmitter array waferboards for use in system applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Storage device performance prediction with CART models (2004)

This work explores the application of a machine learning tool, CART modeling, to storage devices. We have developed approaches to predict a device's performance as a function of input workloads, requiring no knowledge of the device internals. Two uses of CART models are considered: one that predicts per-request response times (and then derives aggregate values) and one that predicts aggregate values directly from workload characteristics. After training on the device in question, both provide reasonably-accurate black box models across a range of test traces from real environments. An expanded version of this paper is available as a technical report [1].
Habitat- and prey-selection of imperial eagles (Aquila heliaca) (2009)

The globally threatened eastern imperial eagle (Aquila heliaca) reaches the western border of its range in the Carpathian Basin, which is the largest known population outside Russia and Kazakhstan. An increasing trend of this population in Hungary and also in the nearby areas of Slovakia has been reported since the 1980’s, when the number of breeding pairs supposedly reached the historical minimum. In the present study we evaluated the dynamics of the Hungarian imperial eagle population between 2001 and 2009. As a result of the continuous increase of the population the monitoring program revealed 105 nesting pairs by 2009. While an expansion of the breeding area towards lowland agricultural habitats was observed, the ratio of pairs inhabiting the historical mountainous breeding habitats decreased from 50% to only 15% during the study period. The frequency of the twoand three-chick broods in respect to single-chick broods increased comparing to the 1980-2000 period showing a higher average annual productivity of the population (1.15 fledglings per nesting pair). Besides the favourable changes in population trend and productivity, the area expansion in the recently occupied lowland habitats also raised several new threats to the population, such as the increased number of illegal poisoning incidents and more frequent collisions with vehicles. Horvath, M., Szitta, T., Fater, I., Kovacs, A., Demeter, I., Firmanszky, G. & Bagyura, J. 2009. Acta Zoologica Bulgarica (in press).
Assay Systems for Profiling Deubiquitinating Activity (2020)

Deubiquitinating enzymes regulate various cellular processes, particularly protein degradation, localization, and protein-protein interactions. The dysregulation of deubiquitinating enzyme (DUB) activity has been linked to several diseases; however, the function of many DUBs has not been identified. Therefore, the development of methods to assess DUB activity is important to identify novel DUBs, characterize DUB selectivity, and profile dynamic DUB substrates. Here, we review various methods of evaluating DUB activity using cell lysates or purified DUBs, as well as the types of probes used in these methods. In addition, we introduce some techniques that can deliver DUB probes into the cells and cell-permeable activity-based probes to directly visualize and quantify DUB activity in live cells. This review could contribute to the development of DUB inhibitors by providing important information on the characteristics and applications of various probes used to evaluate and detect DUB activity in vitro and in vivo.
Improving defect localization techniques with laser beam with specific analysis and set-up modules (2012)

This paper describes a way to improve commonly used static laser stimulation techniques. Several analysis and set-up modules are presented to enrich them. Quickly assembled, combinable and easily adaptable, they allow for example to face atypical failure analysis cases. Effectiveness of this methodology is verified by two cases study. The proposed methodology further extends the capabilities of Laser Stimulation techniques in debug design and characterization domains.
Cross-Reactive B-Cell Epitopes of Microbial and Human Heat Shock Protein 60/65 in Atherosclerosis (2003)

Antibodies to microbial HSP60/65 recognize specific epitopes on human HSP60. These cross-reactive epitopes were shown to serve as autoimmune targets in incipient atherosclerosis and might provide further insights into the mechanisms of early atherogenesis.
Reduction of experimental myocardial infarct size by pre-treatment with magnesium sulfate in rats. (1991)

Experimental myocardial infarction was induced in albino rats by administration of isoprenaline hydrochloride, 85 mg/kg, sc, daily for two consecutive days. Such rats were pretreated with either saline or magnesium sulfate (60 mg/kg) po, daily for three weeks, to serve as control or treated groups respectively. Heart specimens were taken for gross and histological examination at 24 hr, on 5th day, 12th day and 21st day. Infarct size was significantly reduced in the magnesium-treated group (P less than 0.05). We conclude that magnesium sulfate exerted a potent prophylactic effect in limiting infarct size in rats.
Operando Near-Ambient Pressure X-ray Photoelectron Spectroscopy Study of the CO Oxidation Reaction on the Oxide/Metal Model Catalyst ZnO/Pt(111) (2019)

The identification of the active sites in heterogeneous catalysis is important for a mechanistic understanding of the structure–reactivity relationship. Among others, the oxide/metal boundaries are expected to contain the active sites in various catalytic reactions. To reveal their nature and their chemical evolution under reaction conditions, the catalytic role of an oxide/metal system consisting of well-ordered ZnO nanoislands grown on Pt(111) in low-temperature CO oxidation was studied by near-ambient pressure X-ray photoelectron spectroscopy (NAP-XPS) in operando conditions, and additionally by ultra-high vacuum scanning tunneling microscopy. To illustrate the special role played by the oxide/metal boundaries, a systematic comparative study of ZnO/Pt(111) with the pristine Pt(111) surface was undertaken. The regimes where mass transfer limitation starts to occur were identified using NAP-XPS and mass spectrometry measurements in combination, allowing a sound discussion on the relation between steady-state molar fractions of reactants/product and surface reactivity. Via the measurement of the steady-state CO2 molar fraction, we observed that the CO oxidation reaction rate over the ZnO/Pt(111) system is superior to that over Pt(111) in a temperature range extending to 410 K. The pivotal, albeit unexpected, role of ZnO-bound hydroxyls was clearly highlighted by the observation of the chemical signature of the CO + OH associative reaction at the ZnO/Pt boundaries. The carboxyl formed at low temperature (410 K) can be the intermediate species in the CO oxidation reaction, the OHs at the Pt/ZnO boundary being the cocatalyst, which explains the synergistic effect of ZnO and Pt. However, the species formed at higher temperature (from 445 K) are formates that would essentially be spectators.
42.1: Invited Paper: Display Electronics Required for AMLCDs with Pixel Level Data‐Line Multiplexing (2003)

Abstract The Pixel Level Data‐Line Multiplexing was demonstrated with high‐resolution AMLCDs last year. This technique reduces the numbers of data‐driver chips, data‐lines, and crossovers of data/gate‐lines by one‐half with the a‐Si technology. The advantages of applying this technique are lower‐cost, lower power‐consumption, and higher‐robustness especially for wide format like digital TV. This invited paper will focus on display electronics required to support the Pixel Level Data‐Line Multiplexing array.
Characterization of secretory leukocyte protease inhibitor as an inhibitor of implantation serine proteinases (2007)

Abstract We have recently identified and characterized two i mplantation s erine p roteinase genes, ISP1 and ISP2, which give rise to a dimeric proteinase, ISP that facilitates embryo invasion during peri‐implantation period. As many proteinases have cognate serpins that regulate their proteolytic activity, we have been investigating anti‐tryptases, expressed during this window of implantation. Here, we report the differential expression of secretory leukocyte protease inhibitor (SLPI) in uterine endometrium around the implantation period. The co‐localization of SLPI and ISP suggests the possibility that SLPI is an ISP serpin and that expression of SLPI may lead to a reduction in ISP activity. The expression of SLPI is down regulated during the window of embryo‐uterine receptivity. Our results are consistent with a model suggesting that the drop in SLPI expression may help to refine the opening of the window of implantation, by allowing the proteolytic activity of embryo invasive serine proteinases such as the ISPs. Mol. Reprod. Dev. 75: 1136–1142, 2008. © 2007 Wiley‐Liss, Inc.