gebhart/patrepeval huggingface dataset:
[Effect of thyroxine on methemoglobin content and the activity of antioxidant enzymes of human erythrocytes in vitro]. (1985)

A study was made of the effect of thyroxine in vitro on the activity of antioxidant enzymes: superoxide dismutase (SOD) and catalase, and on the methemoglobin content in the erythrocytes of 23 healthy persons aged 17-25. Erythrocyte incubation was performed in different media: in their own plasma, a weak solution of NaOH, tris-HCl buffer solution (pH 7.4) with thyroxine in the physiological concentration and without it. The enzyme activity was compared in the native and incubated erythrocytes. After the incubation of erythrocytes with thyroxine in their own plasma the SOD and catalase activity showed a statistically significant rise, and the methemoglobin content decreased. This effect was undetectable in the incubation of erythrocytes with thyroxine in tris-buffer solution. Direct incubation of SOD with thyroxine isolated from the erythrocytes did not cause any changes in enzyme activity. Probably the interaction of thyroxine with erythrocyte membrane components is important for the implementation of the hormonal effect. Some unidentified factors contained in the blood plasma may play a role in the SOD activation. The authors discuss thyroxine ab to cause rapid regulation of the activity antioxidant enzymes.
Why Parents Hate TV. (1996)

Activation of the Akt signal-transduction pathway seems to be a crucial event for the induction of parietal cell maturation and differentiation.
Melanocytic Lesions (2022)

Superficial spreading melanoma (SSM) is the most common histological subtype, accounting for up to 66% of all cutaneous melanomas. A SSM is defined as an invasive melanoma that has an in situ component beyond three rete ridges of its invasive component. It is characterized by invasion of malignant melanocytes both singly and in nests upward within the epidermis (pagetoid spread) and radially at the dermo-epidermal junction (DEJ). These histologic features correlate with the dermoscopic features found at the edge of a SSM. Nested melanoma is a histopathologic variant of SSM, characterized by large intraepidermal nests, sharp lateral circumscription, and focal areas of lentiginous proliferation of melanocytes at the DEJ. Nested melanomas usually present as pigmented flat lesions with irregular borders on the trunk and extremities of patients older than 60 years.
Electron beam transport with current above the Alfven--Lawson limit (1989)

The quasisteady state of a magnetized electron beam with a current above the Alfven-Lawson limit in a cylindrical waveguide of finite length is analyzed. The distribution of the electrostatic field, the limiting current, and the critical length of the waveguide are found in a two-dimensional system. The basic characteristics of the beam for the injection of a current above the limit---the position of the virtual cathode, the beam thickness, and the current which can be transported---are determined. The current which can be transported may exceed the theoretical limit. The accuracy of the analytic results is confirmed by comparison with the results of experiments and numerical simulations.
Evaluation of FR901464 analogues in vitro and in vivo (2010)

This study was designed to determine the in vitro and in vivo antitumor behaviour of three analogues of the natural product FR901464. All analogues demonstrated effective inhibition of cell proliferation. Minimal in vivo antitumor activity was observed, warranting further PK and antitumor efficacy studies.
On-Shelf Availability in Retailing (2015)

Ensuring high On-Shelf Availability (OSA) is essential for retailers today. It is a measure of retailer performance. Out-of Stock is a major problem in retailing, as it leads to lost sales and decreased consumer loyalty. The term "Out-of-Stock" is used to describe a situation where a consumer does not find the product on the shelf, at the time he/she wishes to purchase it. The root causes leading to OOS include inventory inaccuracy, unexpected high demand, restock frequency and poor shelf monitoring.
LABORATORY PARASITISM BY PHYMASTICHUS COFFEA (HYMENOPTERA: EULOPHIDAE) UPON NON-TARGET BARK BEETLES ASSOCIATED WITH COFFEE PLANTATIONS (2004)

Phymastichus coffea (LaSalle) is an African parasitoid of adults of the coffee berry borer Hypothenemus hampei (Ferrari) that has been introduced to Mexico and other Central and South American countries for the biological control of this important pest. The present study assessed the host specificity of this parasitoid in the laboratory. We tested the acceptance and parasitism of P. coffea on five species of bark beetle adults commonly found in coffee plantations of Mexico: Hypothenemus crudiae, H. plumeriae, H. eruditus, Scolytodes borealis and Araptus fossifrons. As a control, we used adults of H. hampei‘ the natural host. P. coffea parasitized and successfully completed its life cycle in H. crudiae and H. eruditus, as well as in H. hampei. The degree to which bark beetles were attacked by P. coffea was estimated by percent of parasitism, which was 64% for H. hampei, 14% for H. crudiae, and 6% for H. eruditus. The risk of potential deleterious effects of the parasitoid on non-target organisms in coffee agroecosystems is discussed.
A Population Pharmacokinetic and Pharmacodynamic Analysis of Peginesatide in Patients with Chronic Kidney Disease on Dialysis (2013)

Peginesatide (OMONTYS®) is an erythropoiesis-stimulating agent that was indicated in the United States for the treatment of anemia due to chronic kidney disease in adult patients on dialysis prior to its recent marketing withdrawal by the manufacturer. The objective of this analysis was to develop a population pharmacokinetic and pharmacodynamic model to characterize the time-course of peginesatide plasma and hemoglobin concentrations following intravenous and subcutaneous administration. Plasma samples (n = 2,665) from 672 patients with chronic kidney disease (on or not on dialysis) and hemoglobin samples (n = 18,857) from 517 hemodialysis patients (subset of the 672 patients), were used for pharmacokinetic-pharmacodynamic model development in NONMEM VI. The pharmacokinetic profile of peginesatide was best described by a two-compartment model with first-order absorption and saturable elimination. The relationship between peginesatide and hemoglobin plasma concentrations was best characterized by a modified precursor-dependent lifespan indirect response model. The estimate of maximal stimulatory effect of peginesatide on the endogenous production rate of progenitor cells (Emax) was 0.54. The estimate of peginesatide drug concentration required for 50% of maximal response (EC50) estimates was 0.4 µg/mL. Several significant (P<0.005) covariates affected simulated peginesatide exposure by ≤36%. Based upon ≤0.2 g/dL effects on simulated hemoglobin levels, none were considered clinically relevant.
Efficient strategy for the molecular diagnosis of intractable early-onset epilepsy using targeted gene sequencing (2018)

NGS is a useful diagnostic tool with great utility for patients with EOE. Diagnostic yields can be maximized with a standardized and team-based approach.
Measurement of breast tissue composition with dual energy cone‐beam computed tomography: A postmortem study (2013)

The results of this study suggest that the water, lipid, and protein contents can be accurately measured using dual kVp cone-beam CT. The tissue compositional information may improve the sensitivity and specificity for breast cancer diagnosis.
New material sheets and their applications. (1994)

The application of new material sheets have been increasing in various fields recently. These sheets are made by wet-laid or dry-laid paper making processes. New material sheets have high performances derived from the material itself. Also, these sheets are porous, light weight, and have good convertibility and cost merits. Some application examples such as electrical parts, construction meterials, heat resistant materials, composite materials, and electrical conductive materials are shown in this paper.
Specific ion effects on membrane potential and the permselectivity of ion exchange membranes (2014)

Membrane potential and permselectivity are critical parameters for a variety of electrochemically-driven separation and energy technologies. An electric potential is developed when a membrane separates electrolyte solutions of different concentrations, and a permselective membrane allows specific species to be transported while restricting the passage of other species. Ion exchange membranes are commonly used in applications that require advanced ionic electrolytes and span technologies such as alkaline batteries to ammonium bicarbonate reverse electrodialysis, but membranes are often only characterized in sodium chloride solutions. Our goal in this work was to better understand membrane behaviour in aqueous ammonium bicarbonate, which is of interest for closed-loop energy generation processes. Here we characterized the permselectivity of four commercial ion exchange membranes in aqueous solutions of sodium chloride, ammonium chloride, sodium bicarbonate, and ammonium bicarbonate. This stepwise approach, using four different ions in aqueous solution, was used to better understand how these specific ions affect ion transport in ion exchange membranes. Characterization of cation and anion exchange membrane permselectivity, using these ions, is discussed from the perspective of the difference in the physical chemistry of the hydrated ions, along with an accompanying re-derivation and examination of the basic equations that describe membrane potential. In general, permselectivity was highest in sodium chloride and lowest in ammonium bicarbonate solutions, and the nature of both the counter- and co-ions appeared to influence measured permselectivity. The counter-ion type influences the binding affinity between counter-ions and polymer fixed charge groups, and higher binding affinity between fixed charge sites and counter-ions within the membrane decreases the effective membrane charge density. As a result permselectivity decreases. The charge density and polarizability of the co-ions also appeared to influence permselectivity leading to ion-specific effects; co-ions that are charge dense and have low polarizability tended to result in high membrane permselectivity.
Integration of 3 dimensional parametric building model with geographic information systems in educational facilities planning and management (2004)

"The efficient management of buildings and grounds of colleges and universities require an increased amount of information that is current, well organized and easy to access. This information is first generated at the planning stage of the facility before it is even designed. A seamless database containing current and accurate information about the facility and a tool that allows decision-makers to graphically relate the database with the physical location of the information provides a system to better integrate the decision making process from planning to actual operations and maintenance of the facility. This thesis presents an operational environment for facilities managers that integrates the 3 dimensional parametric building modeling with geographic information systems, both related to a common database, and explores the possible benefits and costs of using this integrated system."
Inhibitory Effect of Ethyl Acetate Extract of the Shaggy Inc Cap Medicinal Mushroom, Coprinus comatus (Higher Basidiomycetes) Fruit Bodies on Cell Growth of Human Ovarian Cancer (2013)

In a previous study, we screened organic extracts of different mushroom mycelia and picked ethyl acetate extract of Coprinus comatus as one of the most active extracts against human ovarian cancer cells. In the current study, we extracted a dry powder of C. comatus fruit bodies using ethyl acetate and examined its effect on the viability of three cell lines originated from human ovarian cancer (ES-2, SKOV-3, and SW-626). This extract was active against all tested cell lines, in a dose-dependent manner (concentrations 50-200 µg/mL, P<0.01). In an attempt to segregate the active fraction, we subjected the extract to chromatography on a silica gel column. The effect of six different fractions and of the crude extract on the viability of ES-2 cells was examined after exposure time of 24 h. Fraction F (last eluted) was significantly more effective than crude extract in the reduction of cell viability (P<0.01). Fraction F was also significantly more active than crude extract in the reduction of viability of SKOV-3 cells. We next identified some of the compounds of fraction F (mainly fatty acids) by gas chromatography-mass spectrometry. In summary, ethyl acetate extract of C. comatus reduced viability of three lines of human ovarian cancer. Fractionation of this extract by a silica gel column enabled the selection of a fraction significantly more active than the original extract.
Can Platelet-Rich Plasma Enhance Tendon Repair? (2008)

In vivo use of PRP, but also of PPP to a certain extent, in tendon injuries might accelerate the catabolic demarcation of traumatically injured tendon matrices and promote angiogenesis and formation of a fibrovascular callus. Whether this will also be beneficial for degenerative tendinopathies remains to be elucidated.
Integrin-like Allosteric Properties of the Catch Bond-forming FimH Adhesin of Escherichia coli (2008)

FimH is the adhesive subunit of type 1 fimbriae of the Escherichia coli that is composed of a mannose-binding lectin domain and a fimbria-incorporating pilin domain. FimH is able to interact with mannosylated surface via a shear-enhanced catch bond mechanism. We show that the FimH lectin domain possesses a ligand-induced binding site (LIBS), a type of allosterically regulated epitopes characterized in integrins. Analogous to integrins, in FimH the LIBS epitope becomes exposed in the presence of the ligand (or "activating" mutations) and is located far from the ligand-binding site, close to the interdomain interface. Also, the antibody binding to the LIBS shifts adhesin from the low to high affinity state. Binding of streptavidin to the biotinylated residue within the LIBS also locks FimH in the high affinity state, suggesting that the allosteric perturbations in FimH are sustained by the interdomain wedging. In the presence of antibodies, the strength of bacterial adhesion to mannose is increased similar to the increase observed under shear force, suggesting the same allosteric mechanism, a shift in the interdomain configuration. Thus, an integrin-like allosteric link between the binding pocket and the interdomain conformation can serve as the basis for the catch bond property of FimH and, possibly, other adhesive proteins.
Imaging the ignition of dense, inhomogenous liquid fuel sprays at elevated temperatures and pressures (2020)

This paper investigates the forced ignition of inhomogeneous, dense liquid fuel sprays. The fuel spray is pure n-Heptane, injected with a prototype gasoline direct injector designed by Delphi for the Engine Combustion Network’s Spray G research. This spray is ignited by a laser spark, delivered by a custombuilt high precision laser traverse system. The spray ignition process is recorded with a high-repetition rate schlieren imaging system. The impact of changes in chamber pressure and temperature on ignition probability statistics are investigated. Ignition probability is reduced by increasing chamber pressure and promoted by increasing chamber temperature. At a constant laminar flame speed, the impact of chamber temperature increase is greater than that of chamber pressure increase.
STAT3 and GR cooperate to drive basal-like triple negative breast cancer gene expression and proliferation (2019)

Abstract Breast cancers can be divided into subtypes with different prognoses and treatment responses based on global gene expression differences. Luminal breast cancer gene expression and proliferation are driven by the transcription factors Estrogen Receptor α (ER), FOXA1 and GATA3. Targeting ER is the most effective therapy for treating luminal breast cancer because ER is the master regulator of the luminal gene expression program. In contrast, it is unclear which transcription factors are responsible for driving the gene expression signature that defines basal-like triple negative breast cancer, and there are no targeted therapies approved to treat this aggressive subtype of the disease. This study utilized integrated analysis of DNA methylation, chromatin accessibility, transcription factor binding, and gene expression in large collections of breast cancer cell lines and patient tumors to identify transcription factors responsible for the basal-like gene expression program. The results of this study indicate that glucocorticoid receptor (GR) and signal transducer and activator of transcription 3 (STAT3) bind to the same genomic regulatory regions that are specifically open and unmethylated in basal-like breast cancer. These transcription factors cooperate to regulate expression of hundreds of genes in the basal-like gene expression signature and these downstream genes are associated with poor prognosis in patients. Furthermore, combination treatment with small molecule drugs that inhibit both transcription factors leads to synergistic decreases in cell proliferation in cell lines and patient-derived organoid models. This study demonstrates that GR and STAT3 cooperate to regulate the basal-like breast cancer gene expression program and provides the basis for improved therapy for basal-like triple negative breast cancer through rational combination of STAT3 and GR inhibitors.
A new strategic neurosurgical planning tool for brainstem cavernous malformations using interactive computer graphics with multimodal fusion images (2012)

The authors report a new method for automatic registration of preoperative imaging data from CT, MRI, and 3D rotational angiography for reconstruction into 1 computer graphic. The diagnostic rate of DVA associated with brainstem cavernous malformation was significantly better using interactive computer graphics than with 2D images. Interactive computer graphics was also useful in helping to plan the surgical access corridor.
Endoscopic findings can predict the efficacy of leukocytapheresis for steroid-naive patients with moderately active ulcerative colitis (2008)

LCAP is a useful and safe therapy for steroid-naive UC patients with moderate disease activity. Moreover, the efficacy of the treatment can be predicted on the basis of endoscopic findings.
Preresonance Raman studies of poly(L‐lysine), poly(L‐glutamic acid), and deuterated N‐methylacetamides (1978)

Abstract The Raman spectra of poly( L ‐lysine) with various structures, ionized poly( L ‐glutamic acid), and deuterated N ‐methylacetamides have been observed using visible and the 257.3‐nm laser lines as the light source. Most of the Raman bands with significantly enhanced intensities in the uv‐excited spectra of the polymers have been assigned to the vibrations associated with the CO and C–N stretching modes, the amide I, II, III, I′, II′, and III′, with reference to the results obtained for simple amide molecules including the deuterated N ‐methylacetamides. Several amide frequencies have been newly identified and the structures of the polymers have been discussed through the comparison of the Raman and ir amide frequencies.
Ein homoleptischer oktaedrischer Nickel(IV)‐Komplex mit sehr starken Zinn(II)‐σ‐Donorliganden (2008)

Von Stannaboraten umhüllt sind die Metallzentren der homoleptischen oktaedrischen MIV-Komplexe [M(SnB11H11)6]8− (M = Ni, Pd, Pt). Spektroskopische Daten und die quadratisch-planare Struktur des entsprechenden vierfach koordinierten NiII-Komplexes [Ni(SnB11H11)4]6− liefern umfassende Beweise für die ausgeprägten σ-Donoreigenschaften des [SnB11H11]2−-Liganden.
Microstructure Study of Ti-6Al-4V Brazed with Ti-15Cu-15Ni Filler Metal / Gefügeuntersuchung von Hartlötverbindungen an Ti-6Al-4V mit dem Zusatzwerkstoff Ti-15 Cu-15Ni (1993)

Article Microstructure Study of Ti-6Al-4V Brazed with Ti-15Cu-15Ni Filler Metal / Gefügeuntersuchung von Hartlötverbindungen an Ti-6Al-4V mit dem Zusatzwerkstoff Ti-15 Cu-15Ni was published on November 1, 1993 in the journal Practical Metallography (volume 30, issue 11).
Distinct Bearing Faults Detection in Induction Motor by a Hybrid Optimized SWPT and aiNet-DAG SVM (2018)

The demand of condition monitoring of induction motors (IM) is progressively increasing to maintain the performance of several important sectors in industry. This issue is of great importance since it prevents IM from failing and breaking down. As most of IM faults occur in bearings, the bearing fault detection (BFD) has become the main topic targeting the optimization of unscheduled downtime and maintenance cost of IM. Besides, emphasizing the causes and predicting failure consequences depend on the identification of the fault type. This paper is motivated by the advances in signal processing techniques and machine-learning systems. This study proposes a novel hybrid approach for BFD based on Optimized Stationary Wavelet Packet Transform for feature extraction and artificial immune system nested within support vectors machines for fault classification. The motor current signatures analysis offers a cost-effective method for BFD. To evaluate the approach, the current signals were collected under various bearing conditions and load levels. The experiment results prove the efficiency of the proposed approach.
Conversion of Benzylic Bromides to Benzaldehydes Using Sodium Nitrate As an Oxidant (2010)

A simple and effective approach for the synthesis of benzaldehydes from benzylic bromides is reported using sodium nitrate as an oxidant with 10% sodium hydroxide. Benzyl bromide is oxidized to benzaldehyde in 91% yield with 98% conversion at 120 °C, whereas 82% of benzyl alcohol is obtained at a temperature of 80 °C in 80 min with 20% sodium nitrate solution.
Genetic Dissection of Vasculitis, Myeloperoxidase-Specific Antineutrophil Cytoplasmic Autoantibody Production, and Related Traits in Spontaneous Crescentic Glomerulonephritis-Forming/Kinjoh Mice (2006)

The spontaneous crescentic glomerulonephritis-forming/Kinjoh (SCG/Kj) mouse is a model of human crescentic glomerulonephritis and vasculitis associated with the production of the myeloperoxidase (MPO)-specific antineutrophil cytoplasmic autoantibody (MPO-ANCA). Although the disease is mediated initially by mutation of the Fas gene (lpr), SCG/Kj mice also have non-Fas predisposing genetic factors. To define these factors, genome-wide quantitative trait locus (QTL) mapping was performed on female (B(6)x SCG/Kj) F(2) intercross mice. Fourteen non-Fas QTLs were identified. QTLs of glomerulonephritis were located on chromosomes 1, 10, 13, 16, and 17, vasculitis on chromosomes 1 and 17, splenomegaly on chromosome 1, hypergammaglobulinemia on chromosomes 1, 2, 4, 6, 7, 11, 13, and 17, antinuclear Ab on chromosomes 1, 8, 10, and 12, and MPO-ANCA production on chromosomes 1 and 10. Significant QTLs derived from SCG/Kj on chromosomes 1, 2, 7, and 13 were designated Scg-1 to Scg-5, respectively, and those derived from B(6) on chromosomes 4, 6, 17, and 10 were designated Sxb-1 to Sxb-4, respectively. Two loci linked to MPO-ANCA production on chromosomes 1 and 10 were designated Man-1 and Man-2 (for MPO-ANCA), respectively. Although both Scg-1 and Scg-2 were on chromosome 1 and shared several functions, it was of interest that aberrant MPO-ANCA production was exclusively controlled by Man-1, the centromeric half region of the Scg-2 chromosomal segment. We also examined the epistatic effects between the lpr mutation and non-Fas susceptibility genes. QTLs are discussed in relation to previously described loci, with emphasis on their candidate genes.
Bioinspired Molecular Design of Light‐Harvesting Multiporphyrin Arrays. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.