gebhart/patrepeval huggingface dataset:
Role of L‐type Ca2+ channels in neural stem/progenitor cell differentiation (2006)

Ca(2+) influx through voltage-gated Ca(2+) channels, especially the L-type (Ca(v)1), activates downstream signaling to the nucleus that affects gene expression and, consequently, cell fate. We hypothesized that these Ca(2+) signals may also influence the neuronal differentiation of neural stem/progenitor cells (NSCs) derived from the brain cortex of postnatal mice. We first studied Ca(2+) transients induced by membrane depolarization in Fluo 4-AM-loaded NSCs using confocal microscopy. Undifferentiated cells (nestin(+)) exhibited no detectable Ca(2+) signals whereas, during 12 days of fetal bovine serum-induced differentiation, neurons (beta-III-tubulin(+)/MAP2(+)) displayed time-dependent increases in intracellular Ca(2+) transients, with DeltaF/F ratios ranging from 0.4 on day 3 to 3.3 on day 12. Patch-clamp experiments revealed similar correlation between NSC differentiation and macroscopic Ba(2+) current density. These currents were markedly reduced (-77%) by Ca(v)1 channel blockade with 5 microm nifedipine. To determine the influence of Ca(v)1-mediated Ca(2+) influx on NSC differentiation, cells were cultured in differentiative medium with either nifedipine (5 microm) or the L-channel activator Bay K 8644 (10 microm). The latter treatment significantly increased the percentage of beta-III-tubulin(+)/MAP2(+) cells whereas nifedipine produced opposite effects. Pretreatment with nifedipine also inhibited the functional maturation of neurons, which responded to membrane depolarization with weak Ca(2+) signals. Conversely, Bay K 8644 pretreatment significantly enhanced the percentage of responsive cells and the amplitudes of Ca(2+) transients. These data suggest that NSC differentiation is strongly correlated with the expression of voltage-gated Ca(2+) channels, especially the Ca(v)1, and that Ca(2+) influx through these channels plays a key role in promoting neuronal differentiation.
Acute renal failure (1999)

Acute renal failure remains an important clinical problem with little progress made in the therapeutic approach over the past 20-30 years. The purpose of this review is to discuss possible etiologies, their diagnosis, differentiation and possible prevention. The pathophysiology of prerenal azotemia and ischemic acute renal failure are also discussed. The importance of understanding different body volume components, the urine analysis and the FE Na(+) are explained.
Safety, tolerability and pharmacokinetics of open label sarcosine added on to anti-psychotic treatment in schizophrenia - preliminary study. (2015)

Sarcosine is a safe compound and might be efficacious in the treatment of schizophrenia.
Supplementary Figure S3 from Genetic Amplification of the NOTCH Modulator LNX2 Upregulates the WNT/β-Catenin Pathway in Colorectal Cancer (2023)

&lt;p&gt;Supplementary Figure S3 PDF file - 2243K, RNAi analysis and measurement of cell viability of amplified and overexpressed chromosome 13 candidate genes&lt;/p&gt;
Transient effects caused by pulsed gas and liquid injections into low pressure plasmas (2010)

The fast injection of liquid droplets into a glow discharge causes significant time variations in the pressure, the chemical composition of the gas and the phases present (liquid and/or solid along with gas). While the variations can be large and important, very few studies, especially kinetic studies, have been published. In this paper we examine the changes brought about in argon plasma by injecting Ar (gas), N2 (gas) hexane (gas) and hexane (liquid droplets). The changes in the RF capacitively coupled power (forward and reflected), electron and ion density (ne, ni), electron temperature (Te) and optical emissions were monitored during the injections. It was found that the Ar injection (pressure change only) caused expected variations. The electron temperature reduced, the plasma density increased and the optical emission intensity remained nearly constant. The N2 and hexane gas injections (chemical composition and pressure changes) also followed expected trends. The plasma densities increased and electron temperature decreased while the optical emissions changed from argon to the injected gas. These all serve to highlight the fact that the injection of evaporating hexane droplets in the plasma caused very little change. This is because the number of injected droplets is too small to noticeably affect the plasma, even though the shift in the chemical composition of the gas caused by evaporation from those same droplets can be very significant. The net conclusion is that using liquid droplets to inject precursors for low pressure plasmas is both feasible and controllable.
Air pollution (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAir pollutionDonald L. FoxCite this: Anal. Chem. 1989, 61, 12, 1–13Publication Date (Print):June 15, 1989Publication History Published online1 May 2002Published inissue 15 June 1989https://pubs.acs.org/doi/10.1021/ac00187a001https://doi.org/10.1021/ac00187a001research-articleACS PublicationsRequest reuse permissionsArticle Views243Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Line scan sampling for visible light communication: Theory and practice (2015)

This paper proposes a novel visible light communication method which consists of two techniques: a high-speed sampling method called line-scan sampling (LSS) and modulation schemes designed for LSS. LSS utilizes the line scan characteristics of CMOS image sensors and it enables high-speed sampling that is a thousand times faster than image frame-based sampling using conventional smartphones. The modulation schemes compensate for shortcomings of LSS and enable visible light communication without perceptible flicker using both current control and PWM control light sources. In this paper, we describe the principle of LSS and two types of modulation schemes, and discuss their experimentally-measured performance.
Capecitabine, an Oral Fluoropyrimidine Carbamate With Substantial Activity in Advanced Colorectal Cancer: Results of a Randomized Phase II Study (2000)

Capecitabine offers a new, effective treatment option as an oral single agent in advanced CRC. Promising overall response rates were reported for all three regimens. The addition of leucovorin to the intermittent regimen had no marked effect on tumor response or median TTP. The intermittent single-agent capecitabine schedule is proposed for phase III evaluation, based on considerations of toxicity, dose-intensity, response rate, and TTP.
Superdirective Metamaterial-Inspired Electrically Small Antenna Arrays (2013)

International audience
Modeling Power Amplifiers using Memory Polynomials (2005)

In this paper we present measured in- and output data of a power amplifier (PA). We compare this data with an AM-AM and AM-PM model. We conclude that a more sophisticated PA model is needed to cope with severe memory effects. We suggest to use memory polynomials and introduce two approaches to deduce the polynomial coefficients from the measured data: the Least-Squares and Crosscorrelation approaches. We construct PA models according to both approaches, using the measured data. We compare the two PA models with the original AM-AM and AM-PM model.
Lifetime analysis of two commercial PV converters using multi-year degradation modelling (2023)

This paper presents a practical method to perform multi-year degradation modeling for power electronics reliability analysis. It will present how to combine a PV mission profile simplification method with a parameter degradation feedback mechanism. The overall method is presented, along with how to characterize the parameters for the method from experimental results. The method and the characterization method are demonstrated against simulated wear-out curves based on experimental lifetime tests. The whole workflow is applied to analyze two commercial PV generator systems in order to compare the inclusion and exclusion of the degradation feedback on lifetime prediction. All model parameters are shown in the paper, and the used mission profiles will be published available online.
Learning Predictive Representations for Deformable Objects Using Contrastive Estimation (2020)

Using visual model-based learning for deformable object manipulation is challenging due to difficulties in learning plannable visual representations along with complex dynamic models. In this work, we propose a new learning framework that jointly optimizes both the visual representation model and the dynamics model using contrastive estimation. Using simulation data collected by randomly perturbing deformable objects on a table, we learn latent dynamics models for these objects in an offline fashion. Then, using the learned models, we use simple model-based planning to solve challenging deformable object manipulation tasks such as spreading ropes and cloths. Experimentally, we show substantial improvements in performance over standard model-based learning techniques across our rope and cloth manipulation suite. Finally, we transfer our visual manipulation policies trained on data purely collected in simulation to a real PR2 robot through domain randomization.
Synthesis of Pyrazole Carboxylic Acid via Cobalt-Catalyzed Liquid Phase Oxidation (1991)

Abstract In the presence of catalytic amount of cobalt acetate(II), manganese acetate(II) and bromide ion, the selective oxidation of 3,5-dichloro-1,4-dimethylpyrazole with molecular oxygen afforded 3,5-dichloro-1-methylpyrazole-4-carboxylic acid in more than 95% yield.
Planarization Properties of Resist and Polyimide Coatings (1983)

The planarization properties or thickness changes on topographical features are examined in detail for several types of spun‐on polymer films. A profilometer is used to measure the step height changes of isolated line features of various dimensions. The viscosity of the solution appears to give a reasonable indication of the spun‐on planarization properties. However, in many cases, the thermal flow of the polymer during a subsequent curing procedure is the dominant planarization mechanism. Methods for producing highly planarized surfaces with positive resist materials are described along with the effects of feature size on the planarization properties.
NMR study of Galeorhinus japonicus myoglobin (1991)

The molecular structure of the active site of myoglobin from the shark, Galeorhinus japonicus, has been studied by 1H-NMR. Some hyperfine-shifted amino acid proton resonances in the met-cyano form of G. japonicus myoglobin have been unambiguously assigned by the combined use of various two-dimensional NMR techniques; they were compared with the corresponding resonances in Physter catodon myoglobin. The orientations of ThrE10 and IleFG5 residues relative to the heme in G. japonicus met-cyano myoglobin were semiquantitatively estimated from the analysis of their shifts using the magnetic susceptibility tensor determined by a method called MATDUHM (magnetic anisotropy tensor determination utilizing heme methyls) [Yamamoto, Y., Nanai, N. & Chûjô, R. (1990) J. Chem. Soc., Chem. Commun., 1556-1557] and the results were compared with the crystal structure of P. catodon carbonmonoxy myoglobin [Hanson, J. C. & Schoenborn, B. P. (1981) J. Mol. Biol. 153, 117-124]. In spite of a substantial difference in shift between the corresponding amino acid proton resonances for the two proteins, the orientations of these amino acid residues relative to the heme in the active site of both myoglobins were found to be highly alike.
Synthesis and Applications of III–V Nanowires (2019)

Low-dimensional semiconductor materials structures, where nanowires are needle-like one-dimensional examples, have developed into one of the most intensely studied fields of science and technology. The subarea described in this review is compound semiconductor nanowires, with the materials covered limited to III-V materials (like GaAs, InAs, GaP, InP,...) and III-nitride materials (GaN, InGaN, AlGaN,...). We review the way in which several innovative synthesis methods constitute the basis for the realization of highly controlled nanowires, and we combine this perspective with one of how the different families of nanowires can contribute to applications. One reason for the very intense research in this field is motivated by what they can offer to main-stream semiconductors, by which ultrahigh performing electronic (e.g., transistors) and photonic (e.g., photovoltaics, photodetectors or LEDs) technologies can be merged with silicon and CMOS. Other important aspects, also covered in the review, deals with synthesis methods that can lead to dramatic reduction of cost of fabrication and opportunities for up-scaling to mass production methods.
Changes and upgrades to the TFTR tritium program (2003)

The program and facilities necessary for the safe handling of tritium at the Tokamak Fusion Test Reactor (TFTR) have undergone substantial evolutionary changes as the period of deuterium-tritium operation approaches. Details of these changes (which pertain to plasma-exhaust handling, water swamping, molecular sieve regeneration, premixed-gas composition, system venting, and tritium supply to neutral beams) are presented. Tritium and process flow are diagrammed, and equipment arrangements are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Facial Nerve Grading System 2.0 (2009)

FNGS 2.0 incorporates regional scoring of facial movement, providing additional information while maintaining agreement comparable to the original scale. Ambiguities regarding use of the grading scale are addressed.
Pathogenic Bacterium Investigation of Soft Tissue Injury Combined with Raw Surface Infection (2005)

OBJECTIVE To understand the situation of bacteria distribution and drug-resistant bacteria of soft tissue injury combined with raw surface infection and apply the evidence of rational use of antibacterial to doctor. METHODS The data of the patients diagnosed as soft tissue injury and infection from 2001 to 2004 in our hospital were reviewed retrospectively and monitored prospectively. RESULTS Of 228 patients,154 cases executed bacteria monitoring,57 of which suffered hospital infection.Totally 104 samples were bacteria positive,66 strains being G~+ cocci and 34 strains G~-bacilli. CONCLUSIONS When patients are just in hospital,the bacteria are mainly G~+ cocci,and as the time of hospitalization lengthening,the bacteria are varied.The bacteria in patients with hospital infection are mainly G~-cocci;we should enforce the monitoring of antibiotic usage and choose the proper antibiotic on the basis of result of drug sensitivity.
Visual evoked potential actuated brain computer interface: a brain-actuated cursor system (2005)

Flash visual evoked potential (FVEP), induced by OFF-to-ON flash, i.e. flash onset, in a light emitting diode (LED) was used to control four cursor movements (left, right, up, down), and left- and right-button clicks on a screen menu. ON or OFF duration in each flashing sequence was designed to be random so that all flashing sequences were mutually independent. Since FVEPs are time-locked and phase-locked to flash onsets of gazed LEDs, segmenting EEG signals based on the flash onsets of each flashing sequence followed by averaging will sharpen epochs evoked by gazed LEDs. Four inexperienced subjects were asked to generate a sequence of cursor commands. Mean recognition and transfer rates were 88% and 3.74 s/command, respectively.
Pharmacodynamics of Vildagliptin in Patients With Type 2 Diabetes During OGTT (2007)

This randomized, open-label, placebo-controlled, 7-period crossover study assessed dose-response relationships following single oral doses (10-400 mg) of vildagliptin in 16 patients with type 2 diabetes mellitus. Plasma levels of parent drug, dipeptidyl peptidase-4 activity, glucose, insulin, and glucagon were measured during 75-g oral glucose tolerance tests performed after an overnight fast, 30 minutes after drug administration. The t(max) for parent drug was observed between 0.5 and 1.5 hours postdose. Both C(max) and AUC(0-8 h) increased dose proportionately. Both onset and duration of dipeptidyl peptidase-4 inhibition were dose dependent, but >90% inhibition occurred within 45 minutes and was maintained for >/=4 hours after each dose. Glucose excursions and glucagon levels during oral glucose tolerance tests were significantly and similarly decreased after each dose of vildagliptin, and insulin levels were significantly and similarly increased after each dose level. Unlike findings during mixed-meal challenges, vildagliptin increases plasma insulin levels during oral glucose tolerance tests in patients with type 2 diabetes mellitus.
Estimating Price Variability in Agriculture: Implications for Decision Makers (1998)

Abstract Using a stochastic version of the POLYSYS modeling framework, an examination of projected variability in agricultural prices, supply, demand, stocks, and incomes is conducted for corn, wheat, soybeans, and cotton during the 1998–2006 period. Increased planting flexibility introduced in the 1996 farm bill results in projections of significantly higher planted acreage variability compared to recent historical levels. Variability of ending stocks and stock-to-use ratios is projected to be higher for corn and soybeans and lower for wheat and cotton compared to the 1986–96 period. Significantly higher variability is projected for corn prices, with wheat and soybean prices also being more variable. No significant change in cotton price variability is projected.
CNT-sorbents for heavy metals: Electrochemical regeneration and closed-loop recycling (2020)

Heavy metal contamination of aquatic environments is a major concern. Carbon nanotubes (CNTs) are among the most effective adsorbents for heavy metal removal due. However, in practice their high cost and uncertain environmental impact necessitates a closed-loop process through sorbent regeneration and recycling. Our work demonstrates heavy metal adsorption by carboxylic
Ovarian Toxicity from Sirolimus (2012)

Low-dose oral sirolimus appears to increase the risk of menstrual-cycle disturbances and ovarian cysts. Monitoring patients for sirolimus-associated ovarian toxicity may be considered.
The numerical simulation of projectile penetration acceleration distribution based on ANSYS/LS-DYNA (2011)

In this paper, the theoretical analysis, field testing, ANSYS finite element analysis software was adopted to analyze the process of projectile penetration. Which established the body of missile and concrete target to obtain the acceleration distribution of missile. So as to provide theoretical support of missile structure, damage assessment, verify the feasibility of solving problems in high-speed penetration response analysis based on ANSYS/LS-DYNA non-linear dynamic finite element analysis.
Maximizing Charge Injection Limits of Iridium Oxide Electrodes with a Programmable Anodic Bias Circuit (2021)

Efficacious stimulation of neural tissues requires high charge injection capacity while minimizing electrode polarization. Applying anodic bias on certain electrode materials is a way to enhance charge injection both <i>in vitro</i> and <i>in vivo</i>. We developed an embedded neurostimulator system that enabled a digital control of user-defined bias levels, without requiring a potentiometer or external voltage source. Comparison of charge injection with and without anodic-bias, as well as at different bias potentials were conducted in phosphate-buffered saline with Blackrock iridium oxide microelectrodes. Results showed that a nine-fold increase in current intensity and charge injection capacity, was achieved with a 0.7 V anodic bias and within electrochemically safe limits.
A national stratification of the global macroeconomic burden of central nervous system cancer (2022)

Macroeconomic losses vary across high- and low-income settings and appear to be region specific. These differences may be explained by differences in regional access to screening and diagnosis, population-level genetic predispositions, and environmental risk factors. Mortality-to-incidence ratios are higher in low- and middle-income countries than in high-income countries, highlighting possible gaps in treatment access. Quantification of macroeconomic losses related to CNS cancer can help to justify the spending of finite resources to improve outcomes for neuro-oncological patients globally.
The Performance of Distance Education Video in Java (2000)

The tremendous growth in both Java and multimedia present an opportunity for cross-platform distance education systems exploiting the power of audio and video to enhance the education process. However, little research has been done on evaluating Java multimedia performance nor on assessing its viability as a platform for distance education. In this paper, we present experiments that measure the multimedia performance of an MPEG-1 client in Java, and evaluate its potential as a distance education platform considering both video frame rate and jitter. We find Just-In-Time compilation, local media access and processor choice significantly affect multimedia performance, while choice of operating system, Java virtual machine and garbage collection have a negligible effect on multimedia performance. While overall Java still lags considerably behind multimedia performance in C==, suitable video performance can be achieved in Java, which, if carefully deployed, promises to enhance distance education systems.
Governance of arteriolar oscillation by ryanodine receptors (2003)

To investigate the role of ryanodine receptors in glomerular arterioles, experiments were performed using an isolated perfused hydronephrotic kidney model. In the first series of studies, BAYK-8644 (300 nM), a calcium agonist, constricted afferent (19.6 +/- 0.6 to 17.6 +/- 0.5 microm, n = 6, P < 0.01) but not efferent arterioles. Furthermore, BAYK-8644 elicited afferent arteriolar oscillatory movements. Subsequent administration of nifedipine (1 microM) inhibited both afferent arteriolar oscillation and constriction by BAYK-8644 (to 19.4 +/- 0.5 microm). In the second group, although BAYK-8644 constricted afferent arterioles treated with 1 microM of thapsigargin (19.7 +/- 0.6 to 16.8 +/- 0.6 microm, n = 5, P < 0.05), it failed to induce rhythmic contraction. Removal of extracellular calcium with EGTA (2 mM) reversed BAYK-8644-induced afferent arteriolar constriction (to 20.0 +/- 0.5 microm). In the third series of investigations, ryanodine (10 microM) but not 2-aminoethoxyphenyl borate (100 microM) abolished afferent arteriolar vasomotion by BAYK-8644. In the fourth series of experiments, in the presence of caffeine (1 mM), the stronger activation of voltage-dependent calcium channels by higher potassium media resulted in greater afferent arteriolar constriction and faster oscillation. Our results indicate that L-type calcium channels are rich in preglomerular but not postglomerular microvessels. Furthermore, the present findings suggest that either prolonged calcium influx through voltage-dependent calcium channels (BAYK-8644) or sensitized ryanodine receptors (caffeine) is required to trigger periodic calcium release through ryanodine receptors in afferent arterioles.