gebhart/patrepeval huggingface dataset:
Grafts and the art of mind's reconstruction (1995)

Abstract The use of neural transplantation to alleviate cognitive deficits is still in its infancy. We have an inadequate understanding of the deficits induced by different types of brain damage and their homologies in animal models against which to assess graft-induced recovery, and of the ways in which graft growth and function are influenced by factors within the host brain and the environment in which the host is operating. Further, use of fetal tissue may only be a transitory phase in the search for appropriate donor sources. Nevertheless, findings from our laboratory and elsewhere have made a prima facie case for successful cognitive reconstruction by graft methods.
Germanium Drift Detectors: from the Idea to the Device (2018)

In order to overcome the energy barrier of 20 keV X-rays, only high-Z materials can provide sufficient detection efficiency and Ge is a natural candidate for drift topologies given the superior properties of carrier transport. On the basis of the established high-quality fabrication capability, times are mature to start a challenging R&D program towards the implementation of Ge drift topologies in a fully planar fabrication process. The planar approach will not only produce a desired and significant jump in spectroscopic performance but will also open the way to the powerful integration of drift and pixelated topologies, leading to optimized detection systems for a wide range of applications with hard X- and gamma rays. The focus of this work is on the technological and design issues in the development of Ge drift detectors in planar technology.
Effect of lenalidomide combined with R-CHOP (R2CHOP) on negative prognostic impact of nongerminal center (non-GCB) phenotype in newly diagnosed diffuse large B-cell lymphoma: A phase 2 study. (2014)

8520 Background: The non-germinal center B-cell like (non-GCB) subtype of diffuse large cell lymphoma (DLBCL) is associated with a worse outcome when treated with RCHOP chemotherapy. Lenalidomide has significant single-agent activity in relapsed DLBCL and might be particularly active in non-GCB DLBCL. We have previously reported that lenalidomide can safely be combined with RCHOP (R2CHOP). This phase 2 study evaluated the efficacy of this combination in newly diagnosed DLBCL and analyzed the outcomes based on DLBCL subtype. Methods: Eligible patients were adults with newly diagnosed, untreated, stages II-IV CD20 positive DLBCL. Patients received oral lenalidomide 25 mg days 1-10 with standard dose R-CHOP every 21 days for 6 cycles. All patients received pegfilgrastim on day 2 of each cycle and aspirin prophylaxis throughout. DLBCL molecular subtype was determined by tumor immunohistochemistry (Hans algorithm) and classified as germinal center B-cell (GCB) vs non-GCB in the R2CHOP patients and 87 control DLBCL patients from the Mayo Clinic Lymphoma Database meeting the same inclusion criteria and treated with conventional RCHOP. Results: 64 DLBCL patients were enrolled. Median age was 65 years (22-87) and 34 patients (53%) had IPI intermediate-high or high. 60 were evaluable for response. The overall response rate was 98% (59/60) with 80% (48/60) complete response (CR). 24 month EFS and OS rates (95% CI) were 59% (48%-74%) and 78% (68-90%), respectively. In RCHOP patients, 24 months PFS and OS were 28% vs 64%, p<0.001 and 46% vs 78% p<0.001 in non-GCB patients vs GCB patients respectively. In contrast, there was no difference in 24 months PFS or OS for R2CHOP treated patients based on non-GCB and GCB subtype, 60% vs. 0.59%, p= 0.83 and 83% vs. 75%, p=0.61 at 2 years respectively. Conclusions: R2CHOP shows promising efficacy in DLBCL. The addition of lenalidomide to RCHOP appears to mitigate the negative impact of non-GCB phenotype on the outcome. A randomized phase 2 study of RCHOP vs. R2CHOP utilizing gene expression profiling classification of DLBCL subtype and led by the Eastern Cooperative Oncology Group (E1412) is currently ongoing. Clinical trial information: NCT00670358.
Studies of Tubulin and Its Polymerisation under Hydrostatic Pressure (2006)

National audience
Bistable molecular conductors with a field-switchable dipole group (2002)

A class of bistable ``stator-rotor'' molecules is proposed, where a stationary bridge (stator) connects the two electrodes and facilitates electron transport between them. The rotor part, which has a large dipole moment, is attached to an atom of the stator via a single sigma bond. Hydrogen bonds formed between the rotor and stator make the symmetric orientation of the dipole unstable. The rotor has two potential minima with equal energy for rotation about the sigma bond. The dipole orientation, which determines the conduction state of the molecule, can be switched by an external electric field that changes the relative energy of the two potential minima. Both orientations of the rotor correspond to asymmetric current-voltage characteristics that are the reverse of each other, so they are distinguishable electrically. Such bistable stator-rotor molecules could potentially be used as parts of molecular electronic devices.
A novel experimental technique for the lateral profiling of oxide and interface state charges in hot-hole degraded n-MOSFETs (1998)

A new experimental technique, based on gate-to-drain capacitance C/sub gd//sup s/ and charge pumping (CP) current, is proposed for the lateral profiting of oxide and interface state charges in the LDD region of the n-MOSFETs. The device is injected with hot holes, which are subsequently removed by a low-level channel hot-electron stress. The degree of neutralization is monitored by C/sub gd//sup s/ until complete annihilation of trapped holes is realized. This allows the effects of oxide and interface state charges on CP characteristics to be clearly distinguished, and the spatial profiles of the two charges to be separately determined.
Identifying and Characterizing a Functional HIV-1 Reverse Transcriptase-binding Site on Integrase (2009)

Integrase (IN) from human immunodeficiency virus, type 1 (HIV-1) exerts pleiotropic effects in the viral replication cycle. Besides integration, IN mutations can impact nuclear import, viral maturation, and reverse transcription. IN and reverse transcriptase (RT) interact in vitro, and the IN C-terminal domain (CTD) is both necessary and sufficient for binding RT. We used nuclear magnetic resonance spectroscopy to identify a putative RT-binding surface on the IN CTD, and surface plasmon resonance to obtain kinetic parameters and the binding affinity for the IN-RT interaction. An IN K258A substitution that disrupts reverse transcription in infected cells is located at the putative RT-binding surface, and we found that this substitution substantially weakens IN CTD-RT interactions. We also identified two additional IN amino acid substitutions located at the putative RT-binding surface (W243E and V250E) that significantly impair viral replication in tissue culture. These results strengthen the notion that IN-RT interactions are biologically relevant during HIV-1 replication and also provide insights into this interaction at the molecular level.
Chokes for alternating-phase fed single-layer slotted waveguide arrays (2002)

The alternating-phase fed array with the choke structure which dispenses with any contact between the slotted plate and the groove feed structure is discussed. It is demonstrated that the choke works very effectively to prevent the leakage in the feed waveguide and to keep the antenna efficiency high. A summary is included of the efficiency of various types of planar antennas as a function of antenna gain and frequency. The alternating-phase array achieves high-gain and high-efficiency performance in spite of the simple fabrication dispensing with any contacts.
Adjusting circuit parasitics to optimize converter switching transient behaviour (2003)

It is shown that the influence of parasitic energy storage in a physical converter circuit on converter operation can be modeled with equivalent lumped element circuits that allow SPICE simulations of complete converter circuits by inclusion of the equivalent circuits. The proposed techniques are demonstrated by an example, and the simulated results are verified experimentally. It is shown that the use of high-permittivity ceramic dielectric materials can significantly change the electromagnetic behavior of connecting structures. The concepts can be applied to practical structures and used to improve the converter behavior-for instance, by using the parasitic capacitance for snubbing. This obviates the need for discrete snubber components, leading to circuits with reduced component count, volume, and mass. The main advantage of the method is the significantly reduced switch stresses due to reduced overshoot and oscillation amplitudes. As a result, the switching device ratings can be reduced while maintaining circuit reliability.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Local vibrational densities of states in glasses: Numerical study of a model of amorphous silicon (1994)

We analyze for the first time the relation between the shape of the local vibrational densities of states (LDOSs) and the local environments of atoms in glasses. We calculated the LDOSs in model silicon glasses by use of a recursion method. The glasses are produced by a constant pressure molecular dynamics method with a three-body potential by Stillinger and Weber. The transverse optic (TO) peaks reduce in height with an increase of the number of the coordinated atoms. The heights of the TO peaks also decrease with the increase of the number of the coordinated atoms that have (2,3,0) Voronoi signature. The heights of the transverse acoustic peak are insensitive to the number of bonds. The origin of the decrease of the TO peak is discussed. The slopes of the low frequency side of the LDOSs are insensitive to the local structure of the glasses. The long-range force field in the present glass is the same as that in the crystal state.
An analysis on porosity formation in A356 aluminium alloy castings (2002)

AbstractThe work on porosity formation and kinetic hydrogen redistribution in A356 aluminium alloy castings by Chiesa et al. was re-examined and analysed in the present study on a semi-empirical basis. The calculated volume percent of porosity in A356 aluminium castings from this study, Vp(%) = K'C0{1—exp[—(tf/tτ) n]}/Pg, can satisfactorily explain the experimental work by Chiesa et al. In the equation, K’,n are constant; C0 is the initial hydrogen content of melt; tf, ttau; are the local solidification time and relaxation time, respectively; and Pg is the gas pressure in the pore.Keywords: porosity formationaluminiumcastinghydrogen
Electron-phonon interaction effects on the direct gap transitions of nanoscale Si films (2011)

This study shows that the dielectric function of crystalline Si quantum wells (c-Si QW) is influenced by both carrier confinement and electron-phonon interactions. The energy shifts and lifetime broadening of the excitonic E1 direct gap transition of c-Si QWs from 2 to 10 nm are found to have a significant dimensional and temperature dependence that can be traced to changes in the phonon dispersion of nanoscale films. The influence of electron-phonon interactions on the dielectric function was verified by altering the phonon dispersion using different dielectric layers above a 5 nm c-Si QW.
In‐situ Investigations of Co@Al2O3 Ammonia Decomposition Catalysts: The Interaction between Support and Catalyst (2022)

Abstract Cracking of ammonia, a hydrogen carrier with high storage capacity, gains increasing attention for fuel cell systems for heavy load transportation. In this work, we studied the influence of metal loading and synthesis temperatures on the properties of Co@Al 2 O 3 catalysts. The combination of in situ bulk characterization methods with in situ surface spectroscopy provides insights into the structure‐property relation of the Co catalyst on the γ‐Al 2 O 3 support. At too high temperatures, the formation of CoAl 2 O 4 during synthesis or during the catalytic reaction itself results in inactive mixed metal aluminium spinels which do not contribute to the catalytic reaction. The amount of ‘active’ Co catalyst thus varies significantly as well as its catalytic activity. The latter is correlated to the size of the reduced Co particles on the alumina support. The experiments also highlight that the state of the catalyst changes after reaction which strongly emphasizes the necessity of in situ studies.
Recanalization of the Collecting Lymphatics in Rabbit Hind Leg (2006)

The present study demonstrated that mature collecting lymphatics are able to regenerate in the adult tissues.
Microplasma devices fabricated in silicon, ceramic, and metal/polymer structures: arrays, emitters and photodetectors (2003)

Recent advances in the development of microplasma devices fabricated in a variety of materials systems (Si, ceramic multilayers, and metal/polymer structures) and configurations are reviewed. Arrays of microplasma emitters, having inverted pyramidal Si electrodes or produced in ceramic multilayer sandwiches with integrated ballasting for each pixel, have been demonstrated and arrays as large as 30 × 30 pixels are described. A new class of photodetectors, hybrid semiconductor/microplasma devices, is shown to exhibit photoresponsivities in the visible and near-infrared that are more than an order of magnitude larger than those typical of semiconductor avalanche photodiodes. Microdischarge devices having refractory or piezoelectric dielectric films such as Al2O3 or BN have extended lifetimes (∼86% of initial radiant output after 100 h with an Al2O3 dielectric) and controllable electrical characteristics. A segmented, linear array of microdischarges, fabricated in a ceramic multilayer structure and having an active length of ∼1 cm and a clear aperture of 80 × 360 µm2, exhibits evidence of gain on the 460.3 nm transition of Xe+, making it the first example of a microdischarge-driven optical amplifier.
Enantioselective Approach to Quinolizidines: Total Synthesis of Cermizine D and Formal Syntheses of Senepodine G and Cermizine C (2013)

The formal syntheses of C5-epi-senepodine G and C5-epi-cermizine C have been accomplished through a novel diastereoselective, intramolecular amide Michael addition process. The total synthesis of cermizine D has been achieved through use of an organocatalyzed, heteroatom Michael addition to access a common intermediate. Additional key steps of this sequence include a matched, diastereoselective alkylation with an iodomethylphenyl sulfide and sulfone-aldehyde coupling/reductive desulfurization sequence to combine the major subunits. The utility of a Hartwig-style C-N coupling has been explored on functionally dense coupling partners. Diastereoselective conjugate additions to α,β-unsaturated sulfones have been investigated, which provided the key sulfone intermediate in just six steps from commercially available starting materials. The formal syntheses of senepodine G and cermizine C have been accomplished through an intramolecular cyclization process of a N-Boc-protected piperidine sulfone.
Carbonyl insertion reaction of iron pentacarbonyl with nonaromatic nitro compounds (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbonyl insertion reaction of iron pentacarbonyl with nonaromatic nitro compoundsHoward AlperCite this: Inorg. Chem. 1972, 11, 5, 976–980Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 May 1972https://pubs.acs.org/doi/10.1021/ic50111a012https://doi.org/10.1021/ic50111a012research-articleACS PublicationsRequest reuse permissionsArticle Views171Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin (2021)

Previous studies have shown that agonists of GPR17 stimulate, while antagonists inhibit feeding. However, whole body knockout of GPR17 in mice of the C57Bl/6 strain did not affect energy balance, whereas selective knockout in oligodendrocytes or pro-opiomelanocortin neurons provided protection from high fat diet-induced obesity and impaired glucose homeostasis. We reasoned that whole body knockout of GPR17 in mice of the 129 strain might elicit more marked effects because the 129 strain is more susceptible than the C57Bl/6 strain to increased sympathetic activity and less susceptible to high fat diet-induced obesity. Consistent with this hypothesis, compared to wild-type mice, and when fed on either a chow or a high fat diet, GPR17 -/- mice of the 129 strain displayed increased expression of uncoupling protein-1 in white adipose tissue, lower body weight and fat content, reduced plasma leptin, non-esterified fatty acids and triglycerides, and resistance to high fat diet-induced glucose intolerance. Not only energy expenditure, but also energy intake was raised. Administration of leptin did not suppress the increased food intake in GPR17 -/- mice of the 129 strain, whereas it did suppress food intake in GPR17 +/+ mice. The only difference between GPR17 +/- and GPR17 +/+ mice of the C57Bl/6 strain was that the body weight of the GPR17 -/- mice was lower than that of the GPR17 +/+ mice when the mice were fed on a standard chow diet. We propose that the absence of GPR17 raises sympathetic activity in mice of the 129 strain in response to a low plasma fuel supply, and that the consequent loss of body fat is partly mitigated by increased energy intake.
End‐capped oligothiophenes—new model compounds for polythiophenes (1992)

New end‐capped oligothiophenes (see figure) have been synthesized via nickel‐catalyzed Grignard cross‐coupling reaction. Dueto the reactive positions in the terminal thiophene units being blocked it is possible to accurately characterize the spectroscopic and electrochemical properties of the materials. Estimation of the properties of an 'ideal' polythiophene consisting of 'infinite' chains can be made via extrapolation. magnified image
Supplementary Fig 13 from WNT/β-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers (2023)

&lt;p&gt;Sup Fig 13&lt;/p&gt;
Do Bismuth Complexes Hold Promise as Antileishmanial drugs? (2018)

Even after 70 years, pentavalent antimonials sodium stibogluconate and meglumine antimoniate remain the most important and cost-effective antileishmanial drugs. However, the drugs cannot be delivered orally and treatment involves intravascular or intramuscular injections for 28 days under strict medical monitoring due to the toxicity of Sb(III). The main alternatives, amphotericin B, pentamidine and miltefosine, are expensive and not without their own problems. Bismuth sits below antimony in the periodic table and is considered to be relatively nontoxic to humans while being capable of providing powerful antimicrobial activity. This review describes recent efforts into developing antileishmanial Bi(III) and Bi(V) drugs, which may resemble Sb analogs in effect and mode-of-action while providing lower mammalian cell toxicity and opportunities of oral delivery. Within the last 10 years, various studies concerning bismuth-based compounds as potential antileishmanial agents have been published. This review seeks to summarize the relevant studies and draw a conclusion as to whether bismuth complexes have the potential to be effective drugs.
The spark ignition of mixtures of asym.-dimethylhydrazine and nitric oxide (1940)

D. A. Bamford and C. H. Bamford, Trans. Faraday Soc., 1940, 36, 1036 DOI: 10.1039/TF9403601036
Cloning and functional expression of a degradation-resistant novel isoform of p27Kip1 (2000)

p27(Kip1) is an inhibitor of cyclin-dependent kinases. It has been implicated as having a role in the induction of growth arrest at the G(1) phase of the cell cycle in response to anti-mitogenic signals such as cell contact and serum starvation. Proteasome-mediated degradation plays an important role in the rapid inactivation of p27(Kip1), causing quiescent cells to re-enter the cell cycle. Although the existence of a second isoform has been suggested, no such isoform was isolated. Through screening of a cDNA library derived from growth-arrested confluent porcine endothelial cells, we obtained clones for a novel isoform of p27(Kip1) in addition to the original isoform. The novel isoform differed from the original isoform at the C-terminus. The tissue-specific expression of the original and novel isoforms was demonstrated at the mRNA and protein levels. An in vitro degradation assay demonstrated this novel isoform to be resistant to proteasome-mediated destruction. The expression as a fusion protein with green fluorescent protein revealed this isoform to be targeted to the nucleus by a bipartite nuclear-localization signal with a C-terminal part different from that of the original isoform. The expression of the novel isoform caused the growth arrest of HeLa cells and an accumulation of cells in the G(0)/G(1) phase, and this effect was similar to that seen with the original isoform. The present study suggests that the novel isoform functions as a negative regulator of the cell cycle, and may play a distinct role. The novel isoform was named p27(Kip1R) because of its resistance to degradation.
Supplementary Fig. S4 from Impact of HER2 Heterogeneity on Treatment Response of Early-Stage HER2-Positive Breast Cancer: Phase II Neoadjuvant Clinical Trial of T-DM1 Combined with Pertuzumab (2023)

&lt;p&gt;Relationship between ERBB2 copy number and pCR. A, Median HER2/CEP17 ratio for the overall population acording to pCR results. P-value is from a Wilcoxon test. B, Median HER2/CEP17 ratio for the hormone receptor-positive and hormone receptor-negative subsets according to pCR results. P-value is from a Wilcoxon test. C, Median HER2/CEP17 ratio for each of the six core biopsy areas from each tumor and association with pCR. A-C, Red represents patients without pCR, and blue represents patients with pCR.&lt;/p&gt;
Wideband non-coherent MIMO capacity (2005)

We consider a multiple-input, multiple-output (MIMO) wideband Rayleigh block fading channel, where the channel state is unknown to both the transmitter and the receiver. With only an average power constraint, we compute the capacity of this channel and consider its interaction with the coherence length, number of transmit and receive antennas and receive signal-to-noise ratio (SNR) per degree of freedom. We establish how large the coherence length has to be in order for the non-coherent channel to have a "near coherent" performance in the wideband regime. More specifically, we show that if the coherence length of the channel is above a certain SNR (bandwidth) dependent threshold, the non-coherent and coherent capacities are the same in the large bandwidth regime. We also propose a signaling scheme that is near-optimal in the wideband regime