gebhart/patrepeval huggingface dataset:
Inhibition of the Transforming Growth Factor β1 Signaling Pathway by the AML1/ETO Leukemia-associated Fusion Protein (2000)

The t(8;21) translocation, found in adult acute myelogenous leukemia, results in the formation of an AML1/ETO chimeric transcription factor. AML1/ETO expression leads to alterations in hematopoietic progenitor cell differentiation, although its role in leukemic transformation is not clear. The N-terminal portion of AML1, which is retained in AML1/ETO, contains a region of homology to the FAST proteins, which cooperate with Smads to regulate transforming growth factor beta1 (TGF-beta1) target genes. We have demonstrated the physical association of Smad proteins with AML1 and AML1/ETO by immunoprecipitation and have mapped the region of interaction to the runt homology domain in these AML1 proteins. Using confocal microscopy, we demonstrated that AML1, and ETO and/or AML1/ETO, colocalize with Smads in the nucleus of t(8;21)-positive Kasumi-1 cells, in the presence but not the absence of TGF-beta1. Using transient transfection assays and a reporter gene construct that contains both Smad and AML1 consensus binding sequences, we demonstrated that overexpression of AML1B cooperates with TGF-beta1 in stimulating reporter gene activity, whereas AML1/ETO represses basal promoter activity and blocks the response to TGF-beta1. Considering the critical role of TGF-beta1 in the growth and differentiation of hematopoietic cells, interference with TGF-beta1 signaling by AML1/ETO may contribute to leukemogenesis.
So‐Called Cellulite (1978)

So‐called cellulite is not a disease in a strict sense. An appropriate term to describe it would be adiposis edematosa. Clinically the condition is characterized by “orange‐peel” skin (enlarged and hyperkeratotic follicular orifices) and the “mattress” phenomenon (flattish protrusions and linear depressions of the skin surface). It is not possible to make an exact distinction between so‐called cellulite and simple obesity. The buttocks and the thighs are the most common sites of the condition. Women of all ages may be affected. When so affected, they complain of a feeling of tightness, heaviness, and tenderness or diffuse spontaneous pain in involved skin. The cause of cellulite, in addition to simple obesity, seems to be the typical inner structure of the subcutis in the female, which is probably dependent on the nature of their hormones. The connection between cutis and subcutis in skin of women displaying the “mattress” phenomenon reveals radial arch‐like structures of the connective tissue, whereas the corresponding structures in males run tangentially. Histologically there are no signs of inflammation. The only pathological changes are slight edema, enlarged lymph vessels in the dermis, and slight degenerative changes in the musculi arrectores pilorum. In the subcutis there is a conspicuous increase in the volume of fat cells. There is no convincing experimental proof of changes in the ground substance of the connective tissue. An increase in the degree of polymerization of the acid glycosaminoglycans has not been shown. For this reason treatment with so‐called “spreading” enzymes does not seem to be rational nor is it indeed effective. Therapy should be restricted to a low‐calorie diet and physiotherapy in the form of exercises, massage, and sports.
Measuring the effect of signal-to-noise ratio on listening fatigue (2010)

Nowadays, by using modern means of communication, people tend to talk longer with each other. This may result in listening fatigue, which hampers cognitive performance. Twenty-four subjects listened to English texts, and answered questions about the text, in two sessions.There was background babble noise added at a signal-to-noise (SNR)ratio of either 0 dB (one session) or 10 dB (the other session). Each session lasted approximately one hour, and every 10 minutes, the listener had to rate his fatigue and effort level on a Borg CR-10 scale. Results show significantly lower fatigue levels at 10 dB than at0 dB, after 20 minutes of listening. For 10-dB SNR, listening effort was significantly lower. In addition, the percentage of correctlyanswered questions was significantly higher at higher signal-to-noise ratio. It is therefore concluded that less noise has a clear positive effect on listening fatigue.
Enzyme Kinetic Measurements Using a Droplet-Based Microfluidic System with a Concentration Gradient (2011)

In this paper, we propose a microfluidic device that is capable of generating a concentration gradient followed by parallel droplet formation within channels with a simple T-junction geometry. Linear concentration gradient profiles can be obtained based on fluid diffusion under laminar flow. Optimized conditions for generating a linear concentration gradient and parallel droplet formation were investigated using fluorescent dye. The concentration gradient profile under diffusive mixing was dominated by the flow rate at sample inlets, while parallel droplet formation was affected by the channel geometry at both the inlet and outlet. The microfluidic device was experimentally characterized using optimal layout and operating conditions selected through a design process. Furthermore, in situ enzyme kinetic measurements of the β-galactosidase-catalyzed hydrolysis of resorufin-β-d-galactopyranoside were performed to demonstrate the application potential of our simple, time-effective, and low sample volume microfluidic device. We expect that, in addition to enzyme kinetics, drug screening and clinical diagnostic tests can be rapidly and accurately performed using this droplet-based microfluidic system.
Characterization of Global and Local Textures in Hot Rolled CGO Fe3%Si (2006)

The present work is an attempt to understand the recrystallisation mechanisms in Fe-3% Si alloys used in transformer cores. After secondary recrystallisation silicon steels exhibit a Goss texture with a more or less important spread depending on the details of the processing route, namely, Conventional Grain Orientation CGO or High Permeability Hi-B. The mechanisms of Goss grain formation during hot rolling and primary recrystallisation, as well as those controlling the first steps of abnormal growth, are not yet well understood. The present work mainly deals with texture characterization of the hot rolled state. Surface, quarter and half thickness samples are prepared from hot-rolled sheet. Global and local textures are characterized by neutron diffraction and electron backscattered diffraction, respectively. The Orientation Distribution Functions and the volume fraction of the different texture components are calculated. The components from global texture measurements are (001)[1-10], (112)[1-10] (α fiber ), (011)[100] (Goss) and (111)[1-21] (111) [1-10](γ fiber). EBSD measurements have shown large variations of texture from the surface to the half thickness of the sheet. These local measurements are related to the global results by rotation about the transverse direction. Moreover, the grain size appears to be inhomogeneous.
QUALITY CHANGES OF FRESH-CUT BUTTERHEAD LETTUCE UNDER SUB- AND SUPERATMOSPHERIC OXYGEN CONDITION (2010)

The effects of controlled atmospheres (CA) containing 5 kPa O 2 and 0 kPa CO 2 , 5 kPa O 2 and 15 kPa CO 2 , 75 kPa O 2 and 0 kPa CO 2 , 75 kPa O 2 and 15 kPa CO 2 , and 21 kPa O 2 and 0 kPa CO 2 (as control) on the respiration rates and visual appearance of fresh-cut butterhead lettuce (Lactuca sativa L. var. capitata L.) were studied. The fresh-cut lettuce was stored for 10 days at 7°C. During the same period and the same gas conditions browning was quantified on the lettuce stems using L * , chroma and hue values. This method has been previously applied for lettuce being L * the best parameter related with enzymatic browning. CA did not show a clear influence on the respiration rates of fresh-cut lettuce. Elevated CO 2 treatments decreased the browning on the lettuce stems. Color changes were also slightly delayed on the stems under high O 2 levels. CA with 5 kPa O 2 did not prevent browning. This O 2 level was probably high enough to allow enzymatic browning on the stems. At the end of storage, fresh-cut lettuce stored under superatmospheric (75 kPa) O 2 condition combined with 15 kPa CO 2 had the best visual appearance reducing the enzymatic browning.
Influenza Vaccination: A Comparison of Antibody Response Obtained by Various Methods of Administration (1949)

Summary and Conclusions Two hundred and forty-three adults and children were inoculated by the subcutaneous or interadermal routes with the combined Type A and Type B influenza virus vaccine. The rise in antibody in adults following intradermal inoculation, using 0.1 ml of vaccine, was comparable to that following subcutaneous inoculation of 0.1 ml. In adults, two intradermal inoculations of 0.1 ml each, given three days apart, did not produce antibody-rises which were significantly greater than those following a single intradermal inoculation. The antibody-rise in children, following two intradermal inoculations of 0.1 ml each, was somewhat greater than that following the same doses given subcutaneously.
Impact of the wetting layer thickness on the emission wavelength of direct band gap GeSn/Ge quantum dots (2017)

International audience
Transmitting Properties of Porous Pb(Zr, Ti)O3 Transducer (1992)

The displacement characteristics of the applied voltage on porous-Pb(Zr, Ti)O 3 (P-PZT) are measured by the laser interferometry system. The static displacement characteristics are measured by applying DC voltage to avoid the interference from the various vibration modes. Also, the dynamic displacement characteristics are measured by applying AC voltage of the resonance frequency at 200 kHz. These displacement characteristics showed a dependence on the porosity of P-PZT, and the displacements increased as the porosity of P-PZT increased. P-PZT is applied to the echo sounder to evaluate the transmitting properties in water, and the improved transmitting sensitivity of 3.5 dB in reference to the conventional (nonporous) PZT, is obtained when the porosity of P-PZT is increased to 27%.
뇌졸중 환자에서 보행 속도와 근활성도 및 족저압의 상관관계 (2009)

Purpose: To examine the correlation between the gait speed and muscle activation or foot pressure in stroke patients. Methods: Twenty five functionally ambulant stroke patients (male/female: 15/10, mean age: 57.65±2.30) were enrolled in this study. The patients were asked to walk on a plate at a self-selected and comfortable speed. Three walking trials were obtained and then averaged for data analysis. The gait speed and foot pressure were measured from a RS-Scan system. Activation of the quadriceps femoris muscle and biceps hamstring muscle (%RVC) were recorded using ProComp InfinitiTM. Results: There was a significant positive correlation between Hamstring muscle activation (%RVC) and gait speed. The gait speed correlated with the foot pressure of the lateral metatarsal zone (M3-5) in the affected side. There was a correlation between the gait speed and the foot pressure of the lateral metatarsal (M3-5) and heel (medial, lateral) zone in the less-affected side. Conclusion: The gait speed is related to hamstring muscle activation and the characteristics of foot pressure. This information was observed in both the affected and less-affected sides, suggesting that rehabilitation programs should be implemented on both sides.
Smart overlay metrology pairing adaptive deep learning with the physics based models used by a lithographic apparatus (2018)

All wafers moving through a microchip nanofabrication process pass through a lithographic apparatus for most, if not all, layers. With a lithographic apparatus providing a massive amount of data per wafer, this paper will outline how physicsbased models can be used to refine UVLS (ultraviolet level sensor) metrology into four unique inputs for use in a deep learning network. Due to the multi-dimensional cross correlation of our deep learning network, we then show that training to a sparse overlay layout with dense inputs results in a hyper dense overly signature. On a testing dataset blind to the training we show that the accuracy of the predictive computational overlay metrology can capture R<sup>2</sup> up to 0.81 of the signature in overlay Y. As a real-world application, we outline how our predictive computational overlay metrology can then be used to designate which wafer combinations, coming from the TWINSCAN system, should have overlay measured with a YieldStar system for possible use with APC (advanced process control).
Liquid–Liquid Phase Separation Produces Fast H-Bond Dynamics in DMSO–Water Mixtures (2020)

Liquid-liquid phase separation is common in complex mixtures, but the behavior of nanoconfined liquids is poorly understood from a physical perspective. Dimethyl sulfoxide (DMSO) is an amphiphilic molecule with unique concentration-dependent bulk properties in mixtures with water. Here, we use ultrafast two-dimensional infrared (2D IR) spectroscopy to measure the H-bond dynamics of two probe molecules with different polarities: formamide (FA) and dimethylformamide (DMF). Picosecond H-bond dynamics are fastest in the intermediate concentration regime (20-50 mol % DMSO), because such confined water exhibits bulk-like dynamics. Each vibrational probe experiences a unique microscopic environment as a result of nanoscale phase separation. Molecular dynamics simulations show that the dynamics span multiple time scales, from femtoseconds to nanoseconds. Our studies suggest a previously unknown liquid environment, which we label "local bulk", in which despite the local heterogeneity, the ultrafast H-bond dynamics are similar to bulk water.
Supplementary Figures S1-S5 from Antibody-Maytansinoid Conjugates Are Activated in Targeted Cancer Cells by Lysosomal Degradation and Linker-Dependent Intracellular Processing (2023)

Supplementary Figures S1-S5 from Antibody-Maytansinoid Conjugates Are Activated in Targeted Cancer Cells by Lysosomal Degradation and Linker-Dependent Intracellular Processing
Analytical Method for Predicting Ferromagnetic Properties of Benzyl-Radical Polymers Based on NBMO Theory (2006)

It has been demonstrated that the high-spin stability of benzyl radical oligomers can be predicted without any quantum chemical calculations. This method is composed of three steps: (1) predicting the shapes of nonbonding molecular orbitals (NBMOs), (2) counting up the mixings of NBMOs, and (3) formulating the mixings for the number of radical centers (N). This treatment enables us to predict the high-spin stability evaluated by ab initio MO calculations involving the post-Hartree−Fock method or the density functional theory (DFT) method.
Direction of Maker Education and School Education (2019)

이 연구는 메이커 교육의 등장배경과 학교교육이 나아갈 방향을 탐색하고자 하였다. 연구방법은 문헌연구 로 이루어졌다. 이 연구를 통해 나타난 연구의 결과는 다음과 같다. 첫째, 메이커 교육은 학생들에게 3D 프린 터를 활용한 새로운 교수방법의 대두이며, 학습동기유발과 적극적 학습태도를 가져오며, 창의력을 향상시킨다. 둘째, 학생들이 학습과정에서 서로의 아이디어를 통해 문제를 해결하고자 함으로써 문제해결력을 높여준다. 셋째, 조별 학습은 상호작용 역량을 강화하고, 협력성과 신뢰감을 높여준다. 자신의 아이디어에 대한 시제품을 만드는 학습과정에서 대화를 통해 서로 간에 도움을 줄 수 있고, 이는 관계형성 능력을 향상시키고, 신뢰감을 높여준다. 넷째, 학생들에게 자신의 소질과 적성에 맞는 타고난 재능을 마음껏 발휘할 수 있는 기회부여가 된 다. 그 동안 학교교육은 시간적, 공간적 제약으로 인해 개인의 재능보다는 주어진 교육내용에 중점을 두는 비 중이 높았다. 다섯째, 아이디어가 시제품으로 나올 수 있는 기회의 확대는 시간과 비용절감을 가져올 수 있다. 여섯째, 학생들이 조별로 메이커 활동을 함으로써 적극성과 책임감을 높여주며, 메이커 공간이 제공됨으로써 집중력이 향상된다. 일곱째, 학교교육이 평생교육이나 직업교육과 협력하는 교육의 개방화가 확산된다.
Studies of ion pairing for salts of [M3(.mu.-H,.mu.-CO)(CO)10]- (M = Fe, Ru) (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies of ion pairing for salts of [M3(.mu.-H,.mu.-CO)(CO)10]- (M = Fe, Ru)K. P. Schick, N. L. Jones, P. Sekula, N. M. Boag, J. A. Labinger, and Herbert D. KaeszCite this: Inorg. Chem. 1984, 23, 14, 2204–2207Publication Date (Print):July 1, 1984Publication History Published online1 May 2002Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/ic00182a046https://doi.org/10.1021/ic00182a046research-articleACS PublicationsRequest reuse permissionsArticle Views47Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
UV-GAN: Adversarial Facial UV Map Completion for Pose-invariant Face Recognition (2017)

Recently proposed robust 3D face alignment methods establish either dense or sparse correspondence between a 3D face model and a 2D facial image. The use of these methods presents new challenges as well as opportunities for facial texture analysis. In particular, by sampling the image using the fitted model, a facial UV can be created. Unfortunately, due to self-occlusion, such a UV map is always incomplete. In this paper, we propose a framework for training Deep Convolutional Neural Network (DCNN) to complete the facial UV map extracted from in-the-wild images. To this end, we first gather complete UV maps by fitting a 3D Morphable Model (3DMM) to various multiview image and video datasets, as well as leveraging on a new 3D dataset with over 3,000 identities. Second, we devise a meticulously designed architecture that combines local and global adversarial DCNNs to learn an identity-preserving facial UV completion model. We demonstrate that by attaching the completed UV to the fitted mesh and generating instances of arbitrary poses, we can increase pose variations for training deep face recognition/verification models, and minimise pose discrepancy during testing, which lead to better performance. Experiments on both controlled and in-the-wild UV datasets prove the effectiveness of our adversarial UV completion model. We achieve state-of-the-art verification accuracy, $94.05\%$, under the CFP frontal-profile protocol only by combining pose augmentation during training and pose discrepancy reduction during testing. We will release the first in-the-wild UV dataset (we refer as WildUV) that comprises of complete facial UV maps from 1,892 identities for research purposes.
Lyme disease and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS): an overview (2012)

Lyme disease (LD) is a complex, multisystemic illness. As the most common vector- borne disease in the United States, LD is caused by bacterial spirochete Borrelia burgdorferi sensu stricto, with potential coinfections from agents of anaplasmosis, babesiosis, and ehrlichiosis. Persistent symptoms and clinical signs reflect multiorgan involvement with episodes of active disease and periods of remission, not sparing the coveted central nervous system. The capability of microorganisms to cause and exacerbate various neuropsychiatric pathology is also seen in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), a recently described disorder attributed to bacterium Streptococcus pyogenes of group A beta-hemolytic streptococcus in which neurologic tics and obsessive-compulsive disorders are sequelae of the infection. In the current overview, LD and PANDAS are juxtaposed through a review of their respective infectious etiologies, clinical presentations, mechanisms of disease development, courses of illness, and treatment options. Future directions related to immunoneuropsychiatry are also discussed.
Glycemic Profiles of Healthy Individuals with Low Fasting Plasma Glucose and HbA1c (2011)

Scant data exists on glucose profile variability in healthy individuals. Twenty-nine healthy subjects without diabetes (86% male; mean age, 38 years) were measured by a CGM system and under real-life conditions. The median percentage of time spent on the blood glucose >7.8 mmol/L for 24 hrs was greater than 10% in both NFG and IFG groups. When subjects were divided into either NFG group (i.e., FPG levels of <5.6 mmol/L; n = 22) or IFG group (FPG levels of 5.6-6.9 mmol/L; n = 7), all CGM indicators investigated but GRADE scores, including glucose variability measures, monitoring excursions, hyperglycemia, hypoglycemia, and 24-hour AUC, did not differ significantly between the two groups. GRADE score and its euglycemia% were significantly different between the two groups. Among various CGM indicators, GRADE score may be a sensitive indicator to discriminate glucose profiles between subjects with NFG and those with IFG.
Comparison of subpixel image registration algorithms (2009)

Research into the use of multiframe superresolution has led to the development of algorithms for providing images with enhanced resolution using several lower resolution copies. An integral component of these algorithms is the determination of the registration of each of the low resolution images to a reference image. Without this information, no resolution enhancement can be attained. We have endeavored to find a suitable method for registering severely undersampled images by comparing several approaches. To test the algorithms, an ideal image is input to a simulated image formation program, creating several undersampled images with known geometric transformations. The registration algorithms are then applied to the set of low resolution images and the estimated registration parameters compared to the actual values. This investigation is limited to monochromatic images (extension to color images is not difficult) and only considers global geometric transformations. Each registration approach will be reviewed and evaluated with respect to the accuracy of the estimated registration parameters as well as the computational complexity required. In addition, the effects of image content, specifically spatial frequency content, as well as the immunity of the registration algorithms to noise will be discussed.
Computer Reconstruction of Plant Growth and Chlorophyll Fluorescence Emission in Three Spatial Dimensions (2012)

Plant leaves grow and change their orientation as well their emission of chlorophyll fluorescence in time. All these dynamic plant properties can be semi-automatically monitored by a 3D imaging system that generates plant models by the method of coded light illumination, fluorescence imaging and computer 3D reconstruction. Here, we describe the essentials of the method, as well as the system hardware. We show that the technique can reconstruct, with a high fidelity, the leaf size, the leaf angle and the plant height. The method fails with wilted plants when leaves overlap obscuring their true area. This effect, naturally, also interferes when the method is applied to measure plant growth under water stress. The method is, however, very potent in capturing the plant dynamics under mild stress and without stress. The 3D reconstruction is also highly effective in correcting geometrical factors that distort measurements of chlorophyll fluorescence emission of naturally positioned plant leaves.
Induction of Labour (2016)

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A Carbon Material as a Strong Protonic Acid (2004)

Incomplete carbonization of sulfoaromatic hydrocarbons results in a carbon material that consists of small polycyclic aromatic carbon sheets with attached SO3H groups (see picture). This insoluble solid acid exhibits remarkably high activity in the formation of ethyl acetate, the hydrolysis of cyclohexyl acetate, and the hydration of 2,3-dimethyl-2-butene.