gebhart/patrepeval huggingface dataset:
Identification and Interpretation of Generalized Two-Dimensional Correlation Spectroscopy Features through Decomposition of the Perturbation Domain (2003)

Generalized two-dimensional correlation spectroscopy offers great scope for revealing the behavior of relationships between components of a system under empirical study. We have developed methods that aid in the interpretation of two-dimensional correlation spectroscopy. These methods include reference patterns for two-dimensional correlation and correlation coefficient maps, their superposition and joint interpretation, and the use of delta functions to decompose them in the perturbation domain. We show how their joint use permits discrimination between similar two-dimensional correlation map features on the basis of different correlation coefficients. We also show how the decomposition of maps into the perturbation domain reflects the dynamic behavior of spectral features over the course of the perturbation and permits discrimination between otherwise highly similar two-dimensional correlation cross-peaks. These approaches simplify the interpretation of two-dimensional correlation spectroscopy maps and facilitate access to their rich information content.
Identification de cultivars de palmier dattier (Phoenix dactylifera L.) par l'amplification aléatoire d'ADN (RAPD) (2000)

L’analyse de l’ADN genomique des feuilles du palmier dattier (Phoenix dactylifera L.) chez quatre cultivars femelles (Deglet nour, Allig, Kentichi, Menakher), un genotype mâle (T23) et leurs descendants hybrides a ete realisee par la technique RAPD (random amplified polymorphic DNA). Des amorces revelant un polymorphisme reproductible au sein de ces genotypes ont ete selectionnees, soit 53 bandes polymorphes (soit 12,5 % du total des bandes) resultant de l’utilisation de 11 amorces selectionnees parmi 122 testees. Les marqueurs RAPD ont permis de caracteriser et de distinguer les differents cultivars, tout en differenciant les geniteurs de leurs descendants. Ils pourraient servir pour l’evaluation du potentiel phœnicicole (qui souffre d’un manque de criteres discriminants), pour l’analyse de la diversite genetique d’un grand nombre des cultivars femelles recenses dans les differents pays du Maghreb et pour assister des programmes de croisements diriges dans la lutte contre le Bayoud (fusariose du palmier dattier).
Revised formula for the density of moist air (CIPM-2007) (2008)

Measurements of air density determined gravimetrically and by using the CIPM-81/91 formula, an equation of state, have a relative deviation of 6.4 × 10−5.
Link-Based Ranking of the Web with Source-Centric Collaboration (2006)

Web ranking is one of the most successful and widely used collaborative computing applications, in which Web pages collaborate in the form of varying degree of relationships to assess their relative quality. Though many observe that links display strong source-centric locality, for example, in terms of administrative domains and hosts, most Web ranking analysis to date has focused on the flat page-level Web linkage structure. In this paper we develop a framework for link-based collaborative ranking of the Web by utilizing the strong Web link structure. We argue that this source-centric link analysis is promising since it captures the natural link-locality structure of the Web, can provide more appealing and efficient Web applications, and reflects many natural types of structured human collaborations. Concretely, we propose a generic framework for source-centric collaborative ranking of the Web. This paper makes two unique contributions. First, we provide a rigorous study of the set of critical parameters that can impact source-centric link analysis, such as source size, the presence of self-links, and different source-citation link weighting schemes (e.g., uniform, link count, source consensus). Second, we conduct a large-scale experimental study to understand how different parameter settings may impact the time complexity, stability, and spam-resilience of Web ranking. We find that careful tuning of these parameters is vital to ensure success over each objective and to balance the performance across all objectives
Estimation of heterosis and pattern of inheritance for elite economic yield traits in opium poppy (<em>Papaver somniferum</em> L.) (2021)

A line × tester analysis was conducted to assets the heterosis, heterobeltiosis and economic heterosis of sixty F1’s by crossing 12 lines/females and 5 testers/males of diverse parents for fourteen viable economical traits in Papaver somniferum L. The analysis of variance concluded that parents vs hybrids contrast were recorded only 50% significant for the characters and rest non-significant for the traits like days to flowering (50%), no. of leaves/plant, pedicel length, no. of capsule/plant, Seed yield, dry husk capsule and codeine alkaloid content (%) indicated, existence of plentiful variability among parents and crosses for all the characters studied. The investigational result revealed that hybrids L10×T2, L10×T5, L12×T3 and L12×T4 exhibited the best heterosis over better as well as economic parent both for more than one traits, namely- no. of capsule, capsule index, seed yield (g/plant), dry husk yield (g/plant), morphine, codeine, thebaine, papervine and nosacapine alkaloid content (%) in desirable direction. Therefore, these promising crosses can be recommended for exploitation of heterosis to obtain appropriate segregants for crop improvement program in opium poppy.
Alumina-zirconia machinable abutments for implant-supported single-tooth anterior crowns. (1998)

Innovative materials and application techniques are constantly being developed in the ongoing search for improved restorations. This article describes a new material and the fabrication process of aesthetic machinable ceramic anterior implant abutments. The ceramic material utilized is a mixture of alumina (aluminum oxide) and ceria (cerium oxide) with partially stabilized zirconia (zirconium oxide). The initial core material is a cylinder with a 9-mm diameter and a 15-mm height, obtained by ceramic injection and presintering processes. The resultant alumina-zirconia core is porous and readily machinable. It is secured to the analog, and its design is customized by machining the abutment to suit the particular clinical circumstances. The machining is followed by glass infiltration, and the crown is finalized. The learning objective of this article is to gain a basic knowledge of the fabrication and clinical application of the custom machinable abutments.
<title>Polarized light-scattering measurements of polished and etched steel surfaces</title> (2000)

The directional dependence of the intensity and polarization of light scattered by a series of steel surfaces was measured. The samples differ by polishing procedure. Theories for light scattering from microroughness and permittivity variations are reviews and used to interpret the results. It is shown that the experimental data can be fit to a combination of the two scattering mechanisms, whereby the relative amplitude of the two scattering sources and the complex degree of correlation are treated as adjustable parameters. The fits show at low degree of correlation at high spatial frequencies. This correlation has a characteristic phase, common for all of the samples. Comparison at the fitted roughness power spectral density (PSD) functions with those obtained by atomic force microscopy (AFM) showed reasonable but not perfect agreement. This study demonstrates how measurements of the polarization of scattered light can be used to quantify the scatter from two different scattering sources.
Optically pumped lasing from a single pillar microcavity with InGaAs/GaAs quantum well potential fluctuation quantum dots (2009)

Here, an optical study is presented on cuboidal single pillar microresonators with a quantum-dot-like emitter formed from local fluctuations in the InGaAs/GaAs quantum well potential. By means of microphotoluminescence, emission spectra as a function of the excitation power density were recorded. In the low excitation spectra a number of sharp lines corresponding to the single quantum dots photoluminescence was observed. With increasing excitation power the spectra become dominated by the microcavity modes, on the background of which an intensive and narrow line appears when a certain threshold excitation power is exceeded. A threshold power corresponding to the onset of the superlinear emission intensity power dependence was determined, which is accompanied by a strong decrease in the emission mode linewidth, where both are the distinctive features of the lasinglike behavior. The threshold power density and the exponent of the superlinear part of the input-output characteristic increase with the pillar lateral size (d) and the quality factor (Q), however, they both decrease when plotted as a function of Q/d2, which is the actual figure of merit of the spontaneous emission coupling factor (β). It shows the dominant influence of the volume change effect over the cavity Q (finesse). Thus, larger β values are assigned to the smaller micropillars, in spite of their lower Q values. A quantum dot character of the lasing has been confirmed in a temperature dependent experiment, which showed a number of emission intensity oscillations instead of the expected monotonic decay with the temperature increase, which is a fingerprint of the spectral tuning of the quantum dot emission spectrum through the optical cavity mode.
Multiple Two-Component Systems Modulate Alkali Generation inStreptococcus gordoniiin Response to Environmental Stresses (2009)

The oral commensal Streptococcus gordonii must adapt to constantly fluctuating and often hostile environmental conditions to persist in the oral cavity. The arginine deiminase system (ADS) of S. gordonii enables cells to produce, ornithine, ammonia, CO(2), and ATP from arginine hydrolysis, augmenting the acid tolerance of the organism. The ADS genes are substrate inducible and sensitive to catabolite repression, mediated through ArcR and CcpA, respectively, but the system also requires low pH and anaerobic conditions for optimal activation. Here, we demonstrate that the CiaRH and ComDE two-component systems (TCS) are required for low-pH-dependent expression of ADS genes in S. gordonii. Further, the VicRK TCS is required for optimal ADS gene expression under anaerobic conditions and enhances the sensitivity of the operon to repression by oxygen. The known anaerobic activator of the ADS, Fnr-like protein (Flp), appeared to act independently of the Vic TCS. Mutants of S. gordonii lacking components of the CiaRH, ComDE, or VicRK grew more slowly in acidified media and were more sensitive to killing at lethal pH values and to agents that induce oxidative stress. This study provides the first evidence that TCS can regulate the ADS of bacteria in response to specific environmental signals and reveals some notable differences in the contribution of CiaRH, ComDE, and VicRK to viability and stress tolerance between the oral commensal S. gordonii and the oral pathogen Streptococcus mutans.
Tuberous Sclerosis: Current Update (2021)

Tuberous sclerosis complex (TSC) is a relatively rare autosomal dominant neurocutaneous disorder secondary to mutations in the <i>TSC1</i> or <i>TSC2</i> tumor suppressor genes. Although manifestation of the classic triad of seizures, intellectual disability, and facial angiofibromas may facilitate timely diagnosis of TSC, the multisystem features that may indicate TSC in the absence of these manifestations remain highly variable. In addition, patients with TSC are at risk of developing multiple benign and malignant tumors in various organ systems, resulting in increased morbidity and mortality. Thus, imaging plays a critical role in diagnosis, surveillance, and management of patients with TSC. It is crucial that radiologists be familiar with TSC and the various associated imaging features to avoid a delayed or incorrect diagnosis. Key manifestations include cortical dysplasias, subependymal nodules, subependymal giant cell astrocytomas, cardiac rhabdomyomas, lymphangioleiomyomatosis, and angiomyolipomas. Renal angiomyolipomas in particular can manifest with imaging features that mimic renal malignancy and pose a diagnostic dilemma. Other manifestations include dermatologic and ophthalmic manifestations, renal cysts, renal cell carcinomas, multifocal micronodular pneumocyte hyperplasia, splenic hamartomas, and other rare tumors such as perivascular epithelioid tumors. In addition to using imaging and clinical features to confirm the diagnosis, genetic testing can be performed. In this article, the molecular pathogenesis, clinical manifestations, and imaging features of TSC are reviewed. Current recommendations for management and surveillance of TSC are discussed as well. <sup>©</sup>RSNA, 2021.
Synergistic Effect between Sphingosine-1-Phosphate and Chemotherapy Drugs against Human Brain-metastasized Breast Cancer MDA-MB-361 cells (2013)

Sphingosine-1-phosphate (S1P) is an important sphingolipid metabolite regulating key physiological and pathophysiological processes such as cell growth and survival and tumor angiogenesis. Significant research evidence links elevated cellular S1P concentration to cancer cell proliferation, migration and angiogenesis. Physiological levels of S1P are tightly regulated and maintained at the low nanomolar level. In cancer, S1P may exist well beyond the low nanomolar level. Recently, we reported that S1P selectively induces cell apoptosis of the breast cancer MCF7 cell line at concentrations higher than 1 µM and co-administration of 1 µM S1P significantly increased the cytotoxicity of chemotherapy drug docetaxel. In this study, we show that S1P caused minor increases in cell proliferation or apoptosis, in a concentration-dependent manner, yet co-administration of 10 µM S1P exhibited a significant synergistic effect with chemotherapy drugs docetaxel, doxorubicin and cyclophosphamide. S1P increased the cytotoxic potential of each drug by 2-fold, 3-fold, and 10-fold, respectively, against the breast cancer metastatic cell line MDA-MB-361. This synergism may suggest improved anticancer drug therapy by co-administration of exogenous S1P.
Sensory denervation with capsaicin does not influence the critical ischemia time in rat island flaps (1989)

Capsaicin causes release and long-term depletion of neuropeptides from sensory neurons. Recently, critical rat pedicle flaps pretreated with capsaicin have shown decreased survival. In the present study, the effect of systemic capsaicin pretreatment on the no-reflow phenomenon was investigated in the rat. Effective depletion of neuropeptides was confirmed with functional tests and immunohistochemistry. Groin island flaps were exposed to 4, 6, 8, 10 or 12 hours of warm ischemia, and flap survival was judged one week postoperatively. In contrast to previously reported negative effects on pedicle flap survival after pretreatment with capsaicin, the present study showed no difference in flap survival between capsaicin-pretreated rats and controls. It is concluded that depletion of neuropeptides from sensory neurons does not have negative effects on the tissue's ability to withstand prolonged complete ischemia. As this contrasts with the findings in critical pedicle flaps, the influence of sensory neuropeptides and the necrosis mechanisms are likely to be different in these two types of ischemic conditions.
Fourier‐transform infrared assay of bile salt‐stimulated lipase activity in reversed micelles (1994)

A Fourier-transform infrared (FT-IR) spectroscopic method has been developed for assaying the bile salt-stimulated human milk lipase (BSSL, EC3.1) catalyzed hydrolysis of triolein in AOT reversed micelles in iso-octane. At 37 degrees C in 50 mmol dm-3 AOT the molar absorbtivities for the carbonyl stretching frequencies for triolein (at 1751 cm-1) and oleic acid (at 1714 cm-1) were 1646 dm3 mol-1 cm-1 and 743 dm3 mol-1 cm-1, respectively. The rate was linearly dependent upon the concentration of enzyme in the water pool up to 10 mg cm-3 and maximum activity was observed at a ratio (w0) of [H2O]:[AOT] = 16.7. Using these conditions, and in the presence of 10 mmol dm-3 sodium taurocholate (TC), the derived Michaelis-Menten parameters Vmax and Km were 57.5 mumol min-1 mg-1 and 5.53 mmol dm-3, respectively. These results are compared with those obtained in an oil-in-water microemulsion system and are discussed in terms of the relative partitioning of the enzyme and the substrate in the aqueous and oil phases and the interfacial concentration of the substrate in the two systems.
Involvement of Liver X Receptor Alpha in Histone Modifications Across the Target Fatty Acid Synthase Gene (2011)

The liver X receptor alpha (LXRα), a member of the nuclear receptor superfamily, has been shown to regulate the expression of the fatty acid synthase (FAS) gene through direct interaction with the FAS promoter. However, its regulation of gene expression is not completely understood. Histone modifications and chromatin remodeling are closely linked to transcriptional activation of genes. In the present study, we examined the effect of LXRα activation or silencing on histone modifications (i.e., acetylation, methylation, and phosphorylation) across the FAS gene, with the aim to investigate whether LXRα could regulate its target gene expression at the epigenetic level. The addition of LXR agonist T0901317 or ectopic expression of LXRα stimulated the FAS transcription, which was coupled with increased levels of histones H3 and H4 acetylation and H3 phosphorylation and methylation at the LXR response element (LXRE). LXR ligation or overexpression induced distinct histone modification patterns at the distal region 2,272 bp upstream from the transcription start site (TSS) and TSS of the FAS gene. Moreover, RNA interference-mediated downregulation of LXRα impaired the histone acetylation and methylation but not phosphorylation on the FAS gene. In conclusion, we provide evidence that LXRα ligation-mediated transcriptional activation of the FAS gene is associated with LXRα-dependent histone acetylation and methylation rather than phosphorylation on this target gene.
The 'orthogonal algorithm' for optical flow detection using dynamic programming (1992)

An algorithm for optical flow detection is introduced. It is based on an iterative search for a displacement field that minimizes the L/sub 1/ or L/sub 2/ distance between two images. Both changes are sliced into parallel and overlapping strips. Corresponding strips are aligned using dynamic programming. Two passes are performed using orthogonal slicing directions. This process is iterated in a pyramidal fashion by reducing the spacing and width of the strips. This algorithm provides very-high-quality matching for calibrated patterns as well as for human visual sensation. The results appear to be at least as good as those obtained with classical optical flow detection methods.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Planar circular loop antennas with self-biased magnetic film loading (2008)

A circular loop antenna with self-biased magnetic film loading at 1.7 GHz is presented. The proposed circular loop antenna is realised by cascading a microstrip loop and a tuning stub. Self-biased NiCo-ferrite magnetic films were used to tune the working frequency of the loop antenna. Three different cases of antennas with films loading were designed and analysed. Antennas with self-biased magnetic films loading working at 1.7 GHz with a tuning range of 50–400% of the antenna bandwidth were achieved.
Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis. (1997)

The early endosome is the first vacuolar compartment along the endocytic pathway. It is the site of internalization and initial processing of amyloid precursor protein (APP) and apolipoprotein E (ApoE), two proteins of etiological importance in Alzheimer's disease, and a putative site of beta-amyloid peptide (Abeta) formation. Here, we identify early endosomes in human pyramidal neurons, using specific compartmental markers and morphometry, and show that in Alzheimer's disease individual endosomes display up to 32-fold larger volumes than the normal average. Endosomal enlargement contributed to an average 2.5-fold larger total endosomal volume per neuron, implying a marked increase in endocytic activity. Endosomal alterations were evident in most pyramidal neurons in Alzheimer brain, detectable at early stages of the disease but absent in several other neurodegenerative disorders examined. In addition, mature and proenzyme forms of the proteases cathepsin B and cathepsin D, a candidate APP secretase, were identified in most early endosomes in Alzheimer brains but were detectable in only a minor proportion of endosomes in normal brain. Expression of the cation-dependent 46 kDa mannose 6-phosphate receptor was elevated in pyramidal neurons of Alzheimer brains, which could be a possible basis for the altered cathepsin trafficking pattern. Enhanced endocytic activity, coupled with increased trafficking to endosomes of proteases, which may have the ability under pathological conditions to generate Abeta, constitutes a potential mechanism by which beta-amyloidogenesis may become accelerated in sporadic AD and also be subject to influences by ApoE.
Cyclic Aminoacyloins. II. F-Strain Limitation of Transannular Interaction between N and CCO (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclic Aminoacyloins. II. F-Strain Limitation of Transannular Interaction between N and CCONelson J. Leonard and Michinori ŌkiCite this: J. Am. Chem. Soc. 1954, 76, 13, 3463–3465Publication Date (Print):July 1, 1954Publication History Published online1 May 2002Published inissue 1 July 1954https://pubs.acs.org/doi/10.1021/ja01642a027https://doi.org/10.1021/ja01642a027research-articleACS PublicationsRequest reuse permissionsArticle Views98Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Physics of Cancer: The Impact of Heterogeneity (2011)

It is a common mistake to view cancer as a single disease with a single possible cure which we have just not found yet. In reality cancer takes on many forms that share a common symptom: uncontrolled cell growth and successful invasion of cancer colonies to remote regions of the body. The key reason why we may never be able to defeat cancer may lie in the extreme heterogeneity of the population of the cells in a tumor: there is no one magic bullet. We will try in this review to show how the developing field of the physics of biological heterogeneity can help us understand and quantify the emergent heterogeneity that makes cancer such a fundamental puzzle.
Safety of direct stenting with the Endeavor stent: results of the Endeavor II continued access registry. (2007)

Direct stenting with the Endeavor stent as deemed feasible by the operator, was safe and effective, and comparable to the results of implantation following predilatation.