gebhart/patrepeval huggingface dataset:
Summary of BISON Development and Validation Activities - NEAMS FY15 Report (2015)

The objective of the NEAMS ToolKit is to develop a “pellet-to-plant” simulation capability useful for predicting performance and safety for a broad range of nuclear reactor power systems. The NEAMS ToolKit has been organized into a Fuels Product Line (FPL) and a Reactor Product Line (RPL) and is modular in design. Within the FPL, a multiscale approach has been adopted in which simulations of fuel performance at the engineering scale are informed by material property and irradiation performance models developed from mesoscale simulations of microstructural evolution. The focus in this report is on development and validation of the engineering-scale fuel performance analysis tool within the FPL, which is BISON. This summary report contains an overview of work performed under the work package enti- tled “FY2015 NEAMS INL-Engineering Scale Fuel Performance & Interface with RPL Tools.” A first chapter identifies the specific FY-15 milestones, providing a basic description of the asso- ciated work and references to related detailed documentation. Where applicable, a representative technical result is provided. A second chapter summarizes major additional accomplishments including 1) a BISON validation paper, 2) a multiphysics coupling paper, 3) application of BI- SON to Reactivity Insertion Accident analysis and 4) use of BISON for uncertainity analysis in fuel modeling. A final chapter outlines FY-16 future work.
Plasmid analysis of Neisseria gonorrhoeae isolates and dissemination of tetM genes in southern Africa 1993-1995 (1997)

One group (145 isolates) of Neisseria gonorrhoeae was collected from municipal clinics in Bloemfontein in 1994 and a second group (65 isolates) in 1995. Penicillin and tetracycline MICs were determined and plasmid analysis performed to monitor antimicrobial susceptibilities in conjunction with the occurrence of plasmids in these isolates. The prevalence of penicillin resistance caused by beta-lactamase plasmids remained constant at 9% during the study period. Three high-level tetracycline-resistant strains (MICs 16 mg/L), the first to be detected in South Africa, were isolated in 1994. Although there was a reduction in the percentage of isolates harbouring 24.5 MDa conjugative plasmids (from 79% in 1994 to 46% in 1995), this was partially counteracted by an increase in TetM-encoding conjugative plasmids (25.2 MDa) from 2% to 18.5%. The tetM genes of 13 isolates shown to exhibit high-level tetracycline resistance were characterized as the American type. The American-type tetracycline resistance plasmid was demonstrated in 11 isolates. Digestion with Bg/l showed that two isolates harboured tetM-encoding plasmids that differed from the American- and Dutch-type plasmids described previously: one isolate contained a plasmid that produced two fragments of different sizes from those of the American-type plasmid and the second isolate possessed an American/Dutch hybrid plasmid. Auxotyping/serotyping and random amplified polymorphic DNA analysis revealed a predominant tetracycline-resistant family (NR/IA-6, genomic group I) in Bloemfontein. As there is a high incidence of chlamydial infections in southern Africa requiring tetracycline therapy, selective pressures exist in the environment for the maintenance and rapid spread of high-level tetracycline-resistant N. gonorrhoeae. It is possible that tetM genes may have emanated from Botswana and/or Namibia to Bloemfontein. The establishment of high-level tetracycline-resistant N. gonorrhoeae in Bloemfontein was seen to be complex as a related group of strains was identified, plasmid dissemination was evident and two new TetM-encoding plasmids were demonstrated. The appearance of these TetM-encoding plasmids indicates either that the American- and Dutch-type plasmids are continuing to evolve or that tetM genes are being introduced into different families of 24.5 MDa conjugative plasmids.
Normalized Design of 90° Phase-Difference Networks (1960)

The theoretical background exists for the design of 90° phase-difference networks. Continued interest in the design of such wide-band networks for single-sideband and other applications indicates the need for methods to ease the computational difficulties inherent in network design involving elliptic functions. Concise design data are given in the form of equations, curves and tables which simplify synthesis of LC or RC all-pass networks by eliminating the above computational difficulties. The normalized design curves presented cover a range of bandwidths of 2000 to 1 and permit the designer to write the response function of all-pass phase-difference networks with over-all complexity of up to 12 real pole-zero pairs.
Prognosis of Pulmonary Embolism with Right Ventricular Dysfunction (2017)

Background: Mortality rate of pulmonary embolism (PE) at 3 months is over 15% for the high risk presentation and varies from 3% to 15% for the intermediate-risk presentation. Thrombolysis in intermediate-risk PE remains a matter of debate.
Methods: We undertook a retrospective study over a 11-year period including patients with high and intermediatehigh- risk PE, hospitalised in a medical ICU in a University hospital, to assess medium and long-term prognosis.
Results: Our series involved 145 patients, of whom 63 presented high risk PE and 82 had an intermediate-highrisk PE. Thirty-six patients (24.8%) died in the intensive care unit (ICU) including high-risk PE: 34/63 (53.9%), of whom 25 after inaugural cardiac arrest (CA); intermediate-high-risk PE: 2/82 (2.4%). On multivariate analysis, high blood lactates (OR: 1.88; IC 95% 1.18-3.02, p=0.0083), resuscitated CA (OR: 12.33; IC 95% 1.1-137.4, p=0.041), low subaortic velocity time integral (VTI) (OR: 9.22, IC 0.38-0.81, p=0.0024) were independent factors of in-ICU mortality. Twenty-seven patients died after ICU discharge. Echocardiographic checks were performed in 63 patients, in which 4 (6.3%) presented a chronic thromboembolic pulmonary hypertension (CTPH).
Conclusion: High-risk PE still has a high mortality rate in the ICU especially when revealed by a cardiac arrest. High blood lactates, resuscitated CA, and low subaortic VTI were independent predictive factors of mortality. In our retrospective cohort, long-term prognosis was good with only 4 cases of CTPH. The low mortality observed with anticoagulant-only treatment do not encourage thrombolysis for management of intermediate-high-risk PE patients.
Reviews (2000)

Abstract Same Sex Domestic Violence: Strategies for change Sandra Lundy and Beth Leventhal (eds) 1999, Sage, 272pp ISBN 0 7619 0323 2 (pbk) £15.99 Ethics and Sex I. Primoratz 1999, Routledge, 205pp ISBN 0 415 09334 1 (pbk) £14.99
Synthesis of Permethrin Metabolites and Related Compounds (1977)

Mono- and dihydroxy derivatives of [1RS]-trans- and [1RS]-cis-permethrin, their ester hydrolysis products, and conjugates of the acid moieties and of 3-phenoxybenzoic acid and 4′-hydroxy-3-phenoxybenzoic acid were prepared for verification and stereochemical assignments of the free and conjugated [14C]-metabolites of the [14C] permethrin isomers. At least 2 different solvent systems were used in each case for cochromatographic identification, with and without derivatization of the compounds. Twenty-nine of the products synthesized are identified as permethrin metabolites in free or conjugated form. These compounds were important in assigning structures for the permethrin metabolites formed in various organisms and enzymatic systems. They should also be useful standards in studies on metabolism of related pyrethroids.
Annexin A1 Interaction with a Zwitterionic Phospholipid Monolayer:  A Fluorescence Microscopy Study (2004)

We present the results of a fluorescence microscopy study of the interaction of annexin A1 with dipalmitoylphosphatidylcholine (DPPC) monolayers as a function of the lipid monolayer phase and the pH of the aqueous subphase. We show that annexin A1-DPPC interaction depends strongly on the domain structure of the DPPC monolayer and only weakly on the subphase pH. Annexin A1 is found to be line active, with preferential adsorption at phase boundaries. Also, annexin A1 is found to form networks in the presence of a domain structure in the monolayer. Our results point toward an important contribution of the unique N-terminal domain to the organization of the protein at the interface.
Resonance magnetometers (1972)

Present-day resonance magnetometers form a very broad class of instruments capable of almost any magnetic-field measurement, especially since the advent of new types having a sensitivity of some 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-10</sup> G. However, the wide variety of existing devices makes any comparison between them difficult. This review will therefore put emphasis on the principles of operation and general properties of resonance magnetometers, rather than give many details on models already described in previous surveys such as the one (1967) by Grivet and Malnar [1]. The background thus provided will be applied to a more specific study of existing types.
Quantification of Gallic acid and Catechin in Drakshasava by Validated HPTLC Densitometry (2012)

A simple, precise and accurate HPTLC method has been established for the determination of gallic acid and catechin in test formulations of Drakshasava as Drakshasava-T and Drakshasava-M prepared by traditional and modern method respectively and also in its marketed formulation. Drakshasava is a polyherbal hydro alcoholic preparation and is used to improve digestion, as blood purifier, in the treatment of anaemia and advised as a choice of remedy in respiratory problems. The developed HPTLC method was validated in terms of precision, accuracy, LOD, LOQ and specificity. The amount of gallic acid in Drakshasava-T, M and in its marketed formulation was found to be 0.0256, 0.0254 and 0.0255% w/w respectively while catechin was found to be 0.0195, 0.0193 and 0.0194% w/w respectively. Quantification of gallic acid and catechin in Drakshasava has been reported first time by validated HPTLC. Furthermore, no TLC densitometric methods have been reported for the quantification of gallic acid and catechin from Drakshasava.
Novel active filter system composed of inverter bypass circuit for suppression of harmonic resonance (1999)

We have developed a novel harmonic compensation system consisting of shunt LC filters on the load side, a step-down transformer on the receiving end, and a small-capacity active filter with one end connected to the secondary winding of the transformer and the other to the load bus. The active filter which constitutes the bypass circuit for the main service transformer is current-controlled to give adequate damping of the harmonic resonance caused by the inductance behind the load bus, especially at lower harmonic frequencies. We have installed this new compensation system in combination with a TCR-type SVC and shunt LC filters at the Yamanashi Maglev Test Line. We present an outline of the reactive power and harmonic current compensation systems, and harmonic resonance test results which show satisfactory performance of the active filter. © 1999 Scripta Technica, Electr Eng Jpn, 129(1): 82–90, 1999
A new vision system: programmable logic devices and digital signal processor architecture (PLD+DSP) (2002)

The authors show a way to establish a good structure for an image processing system. Image processing algorithms are classified as a function of the input/output information structure. Then a whole system is created, with different processing architectures inside, one for each group in the classification. The main devices in the whole machine are a digital signal processor (DSP), and specific hardware designs into erasable programmable logic devices (EPLDs). It is shown how these specific designs can be made with a few different printed circuit boards, and specific circuits are loaded from a library into EPLD chips. This library is prepared in the computer, and the machine is easily adapted to a specific application.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Investigational Drug Information (1975)

The drug information appearing in this column is for investigational drugs studied in clinical research protocols being pursued in the Clinical Center at the National Institutes of Health. This same information, in the form of an “Investigational Drug Fact Sheet,” is distributed, prior to its use, to the dispensing pharmacist and the appropriate nursing units involved in the administration of the drugAs with all investigational drugs, the drugs reported in this column have a Notice of Claimed Investigational Exemption for o New Drug (IND) assigned to them by the Food and Drug Administration (F.D.A.).
Determination of piperaquine concentration in human plasma and the correlation of capillary versus venous plasma concentrations (2020)

Capillary and venous plasma PQ measures are nearly identical overall, but not readily exchangeable due to large variation. Further correlation study accounting for disposition phases may be necessary.
Indium-111 labeled tissue plasminogen activator (1985)

Although radiolabeled fibrinogen has been used successfully for detection of thromboemboli by imaging, plasminogen activators offer the advantage of clot detection after active fibrin deposition has ceased. The authors have labeled recombinant tissue plasminogen activator (rTPA) with indium-111 (In) and studied its properties in vivo. Using the cyclic anhydride and standard methodology, an average of about 1 DTPA group per molecule was attached and the protein was labeled with In to a specific activity of 2-3 mCi/mg. Size exclusion HPLC showed each preparation to be of high radiochemical purity and that the In was bound only to the DTPA groups. In vivo clot localization was investigated using a canine clot model in which thrombogenic catheters are placed in a femoral artery and/or in the jugular vein prior to the administration of labeled rTPA. After administration of 0.5-1.0 mg of In-rTPA, blood and serum activity levels were found to decrease with a half time of 8 +- 1 min. in good agreement with the literature value of 7 min. for unlabeled rTPA. Clot:blood and clot:serum ratios were found to increase rapidly, in one study reaching 6.3 after 31 min. Because of the short residence time of rTPA in blood, activity inmore » cardiac and pulmonary blood pools decreased rapidly such that clots were visualized within minutes of injection. The authors conclude that rTPA may be labeled with In without destroying the molecule's ability to localize in clot and that, with this agent, useful images of forming clot may be obtained within one hour of administration. This protein may therefore be ideal for imaging pulmonary and cardiac thromboemboli by gamma scintigraphy.« less
Deflected Versus Preshaped Soft Pneumatic Actuators: A Design and Performance Analysis Toward Reliable Soft Robots (2021)

Soft pneumatic actuators (SPAs) are customizable and conformable devices that enable desired motions in soft robots. Interactions with the environment or handling during their fabrication could introduce defects into SPAs that affect their performance. These defects could lead to high-stress concentrations in the SPA body and heterogeneous, unrepeatable, or inconsistent expansion affecting their reliability. In this work, we aim to improve the reliability of soft robots by modeling and characterizing the performance of SPAs with widely used chamber shapes and cross-sectional geometries under variable loading conditions. We also compare their capacity to provide homogeneous, repeatable, and time-wise consistent expansion with low-stress concentrations and provide a set of principles for the design of reliable SPAs. Expansion of SPAs with Straight chambers demonstrated to be more repeatable, with an average deviation of 0.06 mm and showed more than a thousand times less stress than any other chamber types. The expansion of preshaped SPAs with helical chambers showed to be up to 500% more homogeneous and 300% more efficient than their deflected counterparts. SPAs with squared cross-sectional geometries displayed more than 1000 times more time-wise consistent expansion over their circular counterparts. We conclude that SPAs that retain less potential energy or are less affected by its effects are more reliable. We derive these results into a set of principles for the design of reliable SPAs. These principles offer solutions to make informed decisions before fabrication to mitigate the most common reliability problems for SPAs and soft robots.
Controlling the Recognition and Reactivity of Alkyl Ammonium Guests Using an Anion Coordination-Based Tetrahedral Cage (2018)

Caged structures have found wide application in a variety of areas, including guest encapsulation and catalysis. Although metal-based cages have dominated the field, anion-coordination-based cages are emerging as a new type of supramolecular ensemble with interesting host-guest properties. In the current work, we report a C<sub>3</sub>-symmetric tris-bis(urea) ligand based on the 2,4,6-triphenyl-1,3,5-triazine spacer, which assembles with phosphate anions to form an A<sub>4</sub>L<sub>4</sub>-type (A = anion, L = ligand) tetrahedral cage, 3, with unusually high packing coefficients (up to 99.5% for the best substrate). Cage 3 is able to adjust its size and shape (from 136 to 216 Å<sup>3</sup>) by bending of the triphenyltriazine plane. This allows it to accommodate relatively large guests. In the case of DABCO, inclusion within the cage allows the degree of methylation to be controlled and the monomethylated product to be isolated cleanly under conditions where mixtures of the mono- and dimethylated adduct are obtained in the absence of cage 3.
Analysis of Rabbit Vascular Responses to DBI, an Ingol Derivative Isolated from Euphorbia canariensis (1997)

We have analysed the effects of 7,12-O-diacetyl-8-O-benzoil-2,3-diepiingol (DBI), an ingol derivative isolated from E. canariensis, on isometric tension developed by isolated rabbit basilar and carotid arteries. Concentration-response curves to DBI (10(-8) - 3 x 10(-5) M) were obtained cumulatively in both arteries at resting tension and active tone (KCI, 50 mM). At resting tension, DBI induced a concentration-dependent contraction, which was not inhibited in Ca(2+)-free medium. H7 (1-(5-isoquinoline sulphonyl)-2-methylpiperazine dichloride) (10(-4) M) inhibited the DBI-induced contraction both in basilar and in carotid arteries. Calmidazolium (10(-4) M) inhibited the maximum contraction of the carotid artery to DBI, and completely abolished the response in the basilar artery. In pre-contracted basilar arteries DBI induced a concentration-dependent relaxation that was not modified by incubation with NG-nitro-L-arginine (L-NOARG; 10(-5) M) or indomethacin (10(-5) M). In the carotid artery with active tone DBI induced further contractions, which were not significantly modified by L-NOARG (10(-5) M) and were potentiated by indomethacin (10(-5) M). These results suggest that DBI contracts rabbit basilar and carotid arteries by a mechanism that is independent of extracellular Ca2+ and involves the participation both of protein kinase C and of calmodulin. DBI relaxes basilar but not carotid arteries by a mechanism independent of the liberation of nitric oxide and prostacyclin. In the carotid artery prostacyclin but not nitric oxide partially counteracts the contractile action of DBI.
A case for dynamic view management (2001)

Materialized aggregate views represent a set of redundant entities in a data warehouse that are frequently used to accelerate On-Line Analytical Processing (OLAP). Due to the complex structure of the data warehouse and the different profiles of the users who submit queries, there is need for tools that will automate and ease the view selection and management processes. In this article we present DynaMat, a system that manages dynamic collections of materialized aggregate views in a data warehouse. At query time, DynaMat utilizes a dedicated disk space for storing computed aggregates that are further engaged for answering new queries. Queries are executed independently or can be bundled within a multiquery expression. In the latter case, we present an execution mechanism that exploits dependencies among the queries and the materialized set to further optimize their execution. During updates, DynaMat reconciles the current materialized view selection and refreshes the most beneficial subset of it within a given maintenance window. We show how to derive an efficient update plan with respect to the available maintenance window, the different update policies for the views and the dependencies that exist among them.
A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds (2015)

Selective Inhibitor of Nuclear Export (SINE) compounds are a family of small-molecules that inhibit nuclear export through covalent binding to cysteine 528 (Cys528) in the cargo-binding pocket of Exportin 1 (XPO1/CRM1) and promote cancer cell death. Selinexor is the lead SINE compound currently in phase I and II clinical trials for advanced solid and hematological malignancies. In an effort to understand selinexor-XPO1 interaction and to establish whether cancer cell response is a function of drug-target engagement, we developed a quantitative XPO1 occupancy assay. Biotinylated leptomycin B (b-LMB) was utilized as a tool compound to measure SINE-free XPO1. Binding to XPO1 was quantitated from SINE compound treated adherent and suspension cells in vitro, dosed ex vivo human peripheral blood mononuclear cells (PBMCs), and PBMCs from mice dosed orally with drug in vivo. Evaluation of a panel of selinexor sensitive and resistant cell lines revealed that resistance was not attributed to XPO1 occupancy by selinexor. Administration of a single dose of selinexor bound XPO1 for minimally 72 hours both in vitro and in vivo. While XPO1 inhibition directly correlates with selinexor pharmacokinetics, the biological outcome of this inhibition depends on modulation of pathways downstream of XPO1, which ultimately determines cancer cell responsiveness.