gebhart/patrepeval huggingface dataset:
Characterization of 177Lu-Affibody-HSA bioconjugate for radionuclide therapy of EGFR-expressing head and neck carcinomas (2011)

1735 Objectives The epidermal growth factor receptor (EGFR) is an attractive target for radionuclide therapy of disseminated head and neck carcinomas. EGFR specific Affibodies have shown excellent tumor localizations in PET and SPECT studies, but on the other hand, display extremely high kidney uptakes (>100%ID/g). This represents a critical concern for high doses to the radiation sensitive kidneys. We have recently demonstrated that a human serum albumin (HSA)-HER2 Affibody conjugate exhibits improved pharmacokinetics. The purpose of this study is to further explore whether radiolabeled EGFR-HSA bioconjugates could be suitable for radionuclide therapy of EGFR expressing tumors. Methods HSA was modified by a site-specific conjugation with DOTA-NHS and the bifunctional crosslinker Sulfo-SMCC. The EGFR Affibody analog Ac-Cys-ZEGFR:1907 was then covalently conjugated with the HSA through the sulfo-SMCC, and the resulting bioconjugate DOTA-HSA-ZEGFR:1907 was further radiolabeled with 64Cu and 177Lu. Radiometal labeled DOTA-HSA-ZEGFR:1907 was subjected to in vitro cell uptake and internalization studies using the human oral squamous carcinoma cell line SAS (n=5). PET, SPECT and biodistribution studies were examined using SAS tumor-bearing mice (n=4). Results Radiolabeling with 64Cu as well as with 177Lu resulted in high radiochemical yields (>70%). The in vitro stability of 177Lu-DOTA-HSA-ZEGFR:1907 in mouse serum was >80% at 168 h. Cell uptake studies displayed a significant (8.4% at 4 h) and specific uptake and the internalization of 177Lu-DOTA-HSA-ZEGFR:1907 could be verified. PET and SPECT using 64Cu-DOTA-HSA-ZEGFR:1907 and 177Lu-DOTA-HSA-ZEGFR:1907, respectively showed good tumor imaging contrasts. The imaging results were consistent with the biodistribution data: 177Lu-DOTA-HSA-ZEGFR:1907 displayed good tumor uptakes (5.1% ID/g) and high liver uptakes (31.5% ID/g) and relatively low kidney uptakes (8.5% ID/g) at 72 h p.i. Conclusions 177Lu-DOTA-HSA-ZEGFR:1907 is a promising agent for radionuclide therapy of EGFR expressing head and neck carcinomas
Analysis and results of the 1995 Yuma ground penetration SAR measurements (2002)

In July and October 1995, a large-scale airborne SAR experiment was conducted in Yuma Proving Ground, Yuma, Arizona to investigate ground penetration radar phenomenology and buried target detection. This paper describes the Yuma experiment and measurement results for many tactical, utility, and environmental targets deployed in the test.
Real-time high-quality View-Dependent Texture Mapping using per-pixel visibility (2005)

We present an extension of View-Dependent Texture Mapping (VDTM) allowing rendering of complex geometric meshes at high frame rates without usual blurring or skinning artifacts. We combine a hybrid geometric and image-based representation of a given 3D object to speed-up rendering at the cost of a little loss of visual accuracy.During a precomputation step, we store an image-based version of the original mesh by simply and quickly computing textures from viewpoints positionned around it by the user. During the rendering step, we use these textures in order to map on the fly colors and geometric details onto the surface of a low-polygon-count version of the mesh.Real-time rendering is achieved while combining up to three viewpoints at a time, using pixel shaders. No parameterization of the mesh is needed and occlusion effects are taken into account while computing on the fly the best viewpoints for a given pixel. Moreover, the integration of this method in common real-time rendering systems is straightforward and allows applying self-shadowing as well as other z-buffer effects.
Mapping Mood: An Evolving Emphasis on Frontal-Limbic Interactions (2002)

This chapter focuses on the use of various imaging techniques to elucidate the functional neuroanatomical substrates mediating normal and abnormal mood states. It is in this framework that a model of depression, emphasizing disruption of frontal-subcortical circuits, is discussed.
Low Body Weight as a Potential Surrogate Risk Factor for Progressive Multifocal Leukoencephalopathy (P2.244) (2014)

Objective: To assess the association between body weight and PML Background: Patient weight as a risk marker for Progressive Multifocal Leukoencephalopathy (PML) has been previously proposed by our group. Data previously presented suggests that weight may serve as a surrogate for natalizumab drug concentration and saturation with higher levels found in lower weight populations. Additional support for an association of weight and the pharmacokinetics of natalizumab is provided in the natalizumab label which states clearance increases with body weight. Methods: A real world cohort of 934 patients was obtained from three Multiple Sclerosis clinics in the US in addition to 826 patients from Sweden. A cohort of 36 PML patients from multiple clinics throughout the US and EU was compared by weight, age and therapy duration. Results: The US natalizumab infusing real world population (median 77 kg) is significantly heavier than the Swedish population (median 69 kg). The PML population weights (median 65.5 kg) were similar in both EU and US groups. When comparing a US infusing population versus a US PML population a statistically significant difference is observed. The US population is significantly older than the EU population and appears to be older than those patients studied in the pivotal trials. Data regarding the association of body weights to natalizumab concentration and saturation will be presented. PML prevalence data in both the US and the EU will also be presented. Conclusions: • A significant difference in weight is seen between the US population and both the Swedish and PML population cohorts. • Body weights may serve as a surrogate marker given the absence of commercially available natalizumab concentration or lymphocyte saturation levels. •Could the differences that are seen in PML prevalence between US and EU populations be at least partially explained by the population weight disparities with higher body weights providing a protective effect against PML development?
Dynamic Survey of Architectural Heritage by High-Speed Microwave Interferometry (2005)

The authors propose the use of a high-speed interferometric radar for remotely measuring both transient displacements and steady-state vibrations of architectural heritage structures in order to test their stability conditions. Demonstrative results of application of the technique to a prominent cultural heritage artwork, the tower of Giotto in Florence, Italy, are reported.
ChemInform Abstract: Intramolecular Radical Cyclization Approach to the Synthesis of Periplanone B. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Electrochromic Contrast Enhancement of Nanostructured Poly(3,4-ethylenedioxythiophene)-Polystyrene Sulfonate Films by Composition/Morphology Control (2009)

Poly(3,4-ethylenedioxythiophene) (PEDOT) films have been electropolymerized from an aqueous micellar polyethylene glycol (PEG) based solution containing sodium poly(styrenesulfonate) (NaPSS) and lithium trifluoromethanesulfonate. On varying the NaPSS content in the electrodeposition bath, two strikingly different nanostructured morphologies were obtained for ensuing PEDOT:PSS films and these have been correlated to the electrochemical and optical performance of the films. The films grown from the formulation with EDOT:NaPSS in a 1:3 weight ratio comprise of a nanoparticulate structure with a to date scarcely reported hexagonal structure. The film surface is also characterized by some unusual floral shapes encompassing elongated grains. TEM studies reveal that in the 1:3 film two dimensional (planar) PEDOT chains are stacked on top of each other with a vertical separation of 4.63 A. On the other hand the film generated from a 1:1 solution shows a texture wherein a random segregation of PSS particles is seen and this adversely affects the electrochromic response of the film. The larger charge storage capacity (4.9 mC cm(-2)), better charge reversibility during coloration and bleaching, good electrochemical cycling stability up to 2500 cycles, higher electronic conductivity and a superior coloration efficiency of 233 cm2 C(-1) at a photopic wavelength of 550 nm under ion intercalation levels of 0.058 to 1.2 mC cm(-2) shown by 1:3 film as compared to the performance of the 1:1 film are ramifications of fast ion movement promoted by the novel microstructure and the hexagonal modification which has rarely been achieved in PEDOT:PSS films.
Acoustic Array Measurements of a 1:10.6 Scaled Airbus A340 Model (2004)

Acoustic array measurements were carried out on a 1:10.6 scaled Airbus A340 model. Tests were done in both the open jet and a closed test section of the DNW-LLF wind tunnel. The purpose of these measurements was to investigate several noise reduction concepts for high-lift devices (slats and flaps) in landing configuration. The possibilities and limitations of arrays for the determination of quantitative results are discussed. Besides the identification of dominant noise source regions with conventional beamforming, local source spectra were determined using a power integration method. For the open jet results, the integration method was applied with and without the ’diagonal removal’ (DR) technique, in which the main diagonal of the cross-power matrix is discarded. It is shown that application of DR results in meaningful local spectra, whereas without DR the results are obscured by the influence of the main diagonal. On the other hand, by comparing integrated spectra with absolute sound levels on farfield microphones, it is shown that the application of DR, in combination with coherence loss, results in significantly reduced absolute levels. However, while the absolute sound levels can be too low, level differences between configurations can be accurately determined under certain conditions. From the closed test section array results, dominant source regions are identified as a function of frequency and angle-ofattack. These results are quantified by application of the integration method to several source areas on the wing. The local and overall effect of noise reduction devices is assessed. The effect of coherence loss on the absolute levels is investigated by varying the effective array size.
The counselor as gatekeeper : social interaction in interviews (1982)

Foreword by John J. Gumperz. Preface. Gatekeeping in Counseling: Processes of Social Selection in Face-to-Face Interaction: An Interview. The Interview as a Social Occasion. A Social and Cultural Ecology of Communication, Empathy, and Rapport. Conclusion. Social Identity and the Organization of Discourse in the Interviews: Basic Concepts. Discourse Organization as Definition of Situation. Through the Looking Glass: The Selective Revelation of Social Identity within the Encounter. The Encounter in Relation to the World Outside It. Research Methods and Procedures: An Overview: Some Principles for the Procedures. Converting Information from the Audiovisual Record into Data. Aspects of Social Organization in Communicative Performance: The Social Organization of Communicative Action. Social Steering at the Level of the Discourse Topic. Social Steering within and across Utterances--The Role of Rhythm in Conversational Cooperation. Discussion. Cultural Organization and Its Effects on the Social Organization of Performance: Cultural Organization in Communication. Cultural Difference and Interactional Rhythm. Cultural Difference and Conversational Cooperation during Explanations. Conclusions. Contrasts in Ways of Asking Questions and Telling Advice: Turning Point I--Discussion of Grades and Courses. Turning Point II--Discussion of the Student's Future Goals Turning Point I--Advice about the Student's Future Goal. Conclusion. Overall Patterns and Summary Evidence: Overview of the Variables. Results. Some Implications for Practice and for Research: Review of Findings and Interpretations. The Interview as a Partially Bounded Encounter. Social Ecology and the Politics of Communicative Knowledge. Implications for Counseling Practice. Some Options for Institutional Change. Options for Counselor Education. Implications for Research in Interactional Sociolinguistics. Appendix A: Scoring Comemberhip Levels for the Interviews: Step I. Determining the Comembership Salience Profile for Each Counselor. Step II. Determing the Comembership Score for Each Interview. Appendix B: Equipment and Its Use in Filming and Recording. Appendix C: Examples of Summary Tables and Corresponding Examples of Transcripts. Appendix D: Descriptions of Uncomfortable Moments and Asymmetry Segments Coding and Procedures. References. Subject Index.
Relation of BMI and Physical Activity to Sex Hormones in Postmenopausal Women (2006)

These associations may, in part, explain the positive associations between overweight/obesity and a sedentary lifestyle on breast cancer risk.
ChemInform Abstract: Properties and Catalytic Applications of Carbon Nanotubes (2013)

Abstract Review: 114 refs.
Virulence regulator AphB enhances toxR transcription in Vibrio cholerae (2010)

Our data indicate that V. cholerae possesses an additional regulatory loop that use AphB to activate the expression of two virulence regulators, ToxR and TcpP, which together control the expression of the master virulence regulator ToxT.
X-Ray Investigation of the High Temperature Structure of (CH3)3NHCdCl3 (1983)

The structural phase transitions in a linear chain compound (CH 3 ) 3 NHCdCl 3 were investigated by an X-ray photographic method. It was found that the high temperature phase above 374 K belongs to the orthorhombic Pbnm (Z=8) rather than to the hexagonal P6 3 /m (Z=6) which was proposed by Chapuis and Zuniga. The structure of this high temperature phase was argued to be characterized by an orientationally disordered state of the trimethyl ammonium ions. An analogy to the triangular Ising lattice is also refered.
Pharmacokinetics and Tissue Distribution of 14 C-Labeled Grape Polyphenols in the Periphery and the Central Nervous System Following Oral Administration (2010)

Grape polyphenols confer potential health benefits, including prevention of neurodegenerative diseases. To determine the absorption and tissue distribution of the complex grape polyphenol mixture, (14)C-labeled polyphenols were biosynthesized by grape cell suspension cultures, during co-incubation with radioisotopically labeled sucrose, and fractionated into polyphenolic subfractions. The pharmacokinetics and distribution of grape polyphenols into blood, brain, and peripheral interstitial fluid were determined by tracking the (14)C label. The blood peak (14)C concentration of the fractions ranged from 15 minutes to 4 hours. Absorption and tissue distribution varied greatly between fractions. Concentrations in interstitial fluid were lower than in blood. The amount of residual label in the brain at 24 hours ranged from 0.1% to 1.7% of the dose, depending on the fraction. (14)C label found in the brain tissue and brain microdialysate indicated that grape polyphenols or their metabolites are able to cross the blood-brain barrier. Using (14)C-labeled plant polyphenols it is possible to track the compounds or their metabolic products into any tissue and determine distribution patterns in spite of low concentrations. A central question regarding the potential role of dietary polyphenolics in neurodegenerative research is whether they are bioavailable in the brain. Our observations indicate that some grape-derived polyphenolics do reach the brain, which suggests their potential value for applications in neurodegenerative disorders.
The duration of human ocular Chlamydia trachomatis infection is age dependent (1999)

We studied the relationship between age and prevalence, duration and incidence of clinical and laboratory evidence of ocular Chlamydia trachomatis infection in a cohort of Gambian subjects examined bi-weekly for 6 months. The duration of disease and infection, estimated by stratified survival analysis, proportional hazards regression and Weibull modelling, was markedly age-dependent. The estimated median duration of disease was 13.2 weeks in 0-4-year-old subjects and 1.7 weeks in those age 15 and over. Adjustment for multiple infections, and for missing observations did not alter this trend. The cumulative incidence rate of disease was reduced threefold with age. More rapid disease resolution is the main source of reduction in prevalence of active trachoma and ocular C. trachomatis infection with age; disease incidence was reduced to a lesser extent. This age-dependent resolution may be effected by adaptive cellular immune mechanisms. Mechanisms responsible for natural immunity should receive appropriate emphasis in vaccine design.
Modifications to the von Laue statistical distribution of the times to breakdown at a polymer-oil interface (2017)

A statistical analysis has been undertaken to determine the statistical and formative times associated with breakdowns along a polymer-oil interface under impulse conditions. Early analysis was based on an assumption that the breakdown data followed the von Laue Distribution. However, it was found that in the Laue plots there were deviations from the expected straight line behavior at short times to breakdown, which may be due to a normal distribution in values of the formative times. In addition, the plots showed multiple straight line sections, which suggested that changes were occurring to the breakdown processes during the experimental run, or that more than one mechanism of breakdown was occurring. Values of the statistical time ts and the formative time t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</sub> were determined from the data by making choices on the straight line section to be considered, and ignoring the effects of the normal distribution on the derived values of t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> and t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</sub> . The present paper is focused on further development of this statistical method, including a rigorous analysis of the experimental data, taking into account the effect that a normal distribution of the formative times has on the derived values of t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> sand t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</sub> . Optimal fits in terms of three parameters: t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> , t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</sub> , and σ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</sub> (the standard deviation of the formative time) have been derived using Kolmogorov-Smirnov statistics to quantify the quality of fit. The quality of these fits and the applicability of this approach is discussed.
Outbreaks in a Rapidly Changing Central Africa — Lessons from Ebola (2018)

Outbreaks in a Rapidly Changing Central Africa Economic and demographic change across Central Africa exacerbates the risk of infectious disease epidemics. But population growth and increasing income and education can also spur demand for infrastructure to support sustainable development, including basic health services.
The Challenge of Establishing Reliable Screening Tests for Selecting Anticancer Metal Compounds (2011)

IntroductionTumor Cell Growth Inhibition and Cell Death Screening AssaysMetal-Based Anticancer Compounds and Gene Expression Microarray TechnologiesMetal-Based Anticancer Compounds and the Proteomic ApproachConcluding Remarks
Abstract 3498: The Association of Breastfeeding in Infancy and Adult Cardiovascular Disease Risk Factors: The Framingham Third Generation Cohort (2007)

Background: Public health recommendations advocate breastfeeding in infancy as a means to reducing later-life obesity. However many prior studies relating breastfeeding to cardiovascular (CVD) risk factors have been limited by lack of adjustment for maternal and participant confounding factors. Methods: In 962 Framingham Third Generation participants (mean age = 41 yrs, 54% women) we related history of breastfeeding (yes vs. no) and CVD risk factors in young-mid adulthood. Breastfeeding data was ascertained via questionnaire from mothers enrolled in the Framingham Offspring Study. Dependent variables were body mass index (BMI), HDL-cholesterol (HDL-c), total cholesterol, triglycerides, fasting blood glucose, C-reactive protein (CRP), systolic (SBP) and diastolic blood pressure (DBP). Covariates for multivariable adjustment were age, sex, hypertension medications, lipid treatment, smoking, birth order, oral contraceptives, hormone replacement, physical activity, education, maternal smoking, maternal education, and maternal BMI. Low HDL was defined as &lt; 50 mg/dL (women) and &lt; 40 mg/dL(men). Adiposity categories were defined by BMI normal [&lt; 25], overweight [≥ 25 to &lt; 30] and obese [≥ 30 kg/m 2 ]. Generalized estimating equations (GEE) were used to account for sibling correlations. Results: Overall 26% of participants were reported by their mother to have been breastfed. Compared to non-breastfed individuals, breastfed offspring had lower adult BMI [adjusted mean 26.1 kg/m 2 vs. 26.9 kg/m 2 , p = 0.04) and higher adult HDL-c levels [adjusted mean HDL 56.6 mg/dL relative to 53.7 mg/dL p = 0.01] in multivariable-adjusted models. Breastfeeding was not associated with other examined adult CVD risk factors. Upon adjustment for BMI the association between breastfeeding and HDL was attenuated (p = 0.09). Breastfeeding was associated with high versus low HDL (multivariable-adjusted OR = 1.55, p = 0.04) but not with overweight or obesity versus normal weight (p = 0.26, 0.13 respectively). Conclusions: Breastfeeding in infancy is inversely associated with adult BMI and positively associated with HDL-c. Associations between breastfeeding and BMI appear to mediate most of the association with HDL-c.