gebhart/patrepeval huggingface dataset:
Orthogonal convolutional modulation for UWB-impulse radio systems: performance analysis and adaptive schemes (2009)

In the context of UWB (ultra-wide band) impulse radio (IR) heterogeneous low data-rate networks, the need for coding/modulation schemes amenable of both coherent and noncoherent detection has emerged. The rationale is the potential coexistence of different classes of nodes, characterized by different complexity and performances. In such scenario, one of the main technical challenges is the design of efficient coding/modulation schemes incorporating forward error correction (FEC) and spreading capabilities, thus providing the necessary processing and coding gain, to guarantee robust communications. In this work, we introduce novel coding schemes exploiting the trellis structure of orthogonal convolutional codes for generating time-hopping sequences suitable for UWB-IR, while simultaneously mapping the information bits onto the transmitted waveforms. Namely, we present a new class of orthogonal convolutional modulation (OCM) schemes, highlighting the trade-offs in terms of coherent vs. non-coherent detection performance. Then we develop an adaptive OCM scheme (AOCM) for application to broadcast transmission in heterogeneous UWB-IR networks, illustrating advantages in terms of energy savings and potential drawbacks.
A technique to train finger coordination and independence after stroke (2010)

The results show significant improvements in finger coordination, force modulation as well as finger independence.
A Textile‐Integrated Polymer Thermoelectric Generator for Body Heat Harvesting (2019)

Abstract Integrating thermoelectric generators (TEGs) into textiles is attractive for body heat harvesting to power wearable electronics. Textile‐integrated TEGs have the advantage of conformity to the body that ensures efficient heat transfer and does not impede movement. Additive printing techniques and solution processable polymer‐based thermoelectric (TE) materials can be used for this purpose. However, a number of fabrication challenges limit the realization of a printed polymer‐based textile TEG using a low cost, scalable, and textile compatible process. In this work, stencil and transfer printing techniques are successfully employed to fabricate a 32‐leg device with a modest fill factor (≈30%) on a commercial sports fabric substrate. PEDOT:PSS and Poly[Na(NiETT)] are formulated into inks and used as the p‐type and the n‐type polymer materials, respectively. The textile‐integrated TE device yields an open circuit voltage of ≈3 mV at Δ T = 3 K. The fabrication process is scaled up to demonstrate an 864‐leg device that yields a voltage output of ≈47 mV. This work is the first demonstration of a textile TEG based on p‐ and n‐type conducting polymers capable of through‐plane body heat harvesting. It serves as a proof‐of‐concept for integrating TE devices into mainstream fabrics and clothing.
Soft handover gain measurements and optimisation of a WCDMA network (2004)

OrangeUK was the first operator in the UK to have an operational WCDMA trial network and in April 1999 it was the first operator within Europe to make live 3G video calls on its then Fujitsu trial WCDMA network. Since then it has chosen Nokia and more recently Alcatel as its UTRAN vendors and has now rolled out the biggest combined 2G/3G network in the UK. This paper initially describes the work undertaken at Orange, investigating the downlink soft handover gain in a WCDMA network. The paper then provides a brief overview of the WCDMA radio optimisation methodology employed by Orange to optimise its WCDMA network.
A thermodynamic tank model for studying the effect of higher hydrocarbons on natural gas storage in metal–organic frameworks (2015)

A thermodynamic model was developed to evaluate the cyclic performance of metal–organic frameworks in adsorbing natural gas containing methane and higher hydrocarbons in a vehicle tank.
Pharmacological evidence for the presence of inhibitory EP2 prostanoid receptors in the pregnant baboon myometrium (1993)

Pharmacological evidence for the presence of inhibitory EP2 prostanoid receptors in the pregnant baboon myometrium. 40th annual meeting of the Society for gynecologic Investigation
2H NMR calculations on polynuclear transition metal complexes: on the influence of local symmetry and other factors (2011)

It is now well-known that (2)H solid-state NMR techniques can bring a better understanding of the interaction of deuterium with metal atoms in organometallic mononuclear complexes, clusters or nanoparticles. In that context, we have recently obtained experimental quadrupolar coupling constants and asymmetry parameters characteristic of deuterium atoms involved in various bonding situations in ruthenium clusters, namely D(4)Ru(4)(CO)(12), D(2)Ru(6)(CO)(18) and other related compounds [Gutmann et al., J. Am. Chem. Soc., 2010, 132, 11759], which are model compounds for edge-bridging (μ-H) and face-capping (μ(3)-H) coordination types on ruthenium surfaces. The present work is in line with density functional theory (DFT) calculations of the electric field gradient (EFG) tensors in deuterated organometallic ruthenium complexes. The comparison of quadrupolar coupling constants shows an excellent agreement between calculated and observed values. This confirms that DFT is a method of choice for the analysis of deuterium NMR spectra. Such calculations are achieved on a large number of ruthenium clusters in order to obtain quadrupolar coupling constants characteristic of a given coordination type: terminal-D, η(2)-D(2), μ-D, μ(3)-D as well as μ(4)-D and μ(6)-D (i.e. interstitial deuterides). Given the dependence of such NMR parameters mainly on local symmetry, these results are expected to remain valid for large assemblies of ruthenium atoms, such as organometallic ruthenium nanoparticles.
Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways (2016)

Spatio-temporal regulation of intracellular signalling networks is key to normal cellular physiology; dysregulation of which leads to disease. The family of three mammalian tribbles proteins has emerged as an important controller of signalling via regulating the activity of mitogen activated protein kinases (MAPK), the PI3-kinase induced signalling network and E3 ubiquitin ligases. However, the importance of potential redundancy in the action of tribbles and how the differences in affinities for the various binding partners may influence signalling control is currently unclear. We report that tribbles proteins can bind to an overlapping set of MAPK-kinases (MAPKK) in live cells and dictate the localisation of the complexes. Binding studies in transfected cells reveal common regulatory mechanisms and suggest that tribbles and MAPKs may interact with MAPKKs in a competitive manner. Computational modelling of the impact of tribbles on MAPK activation suggests a high sensitivity of this system to changes in tribbles levels, highlighting that these proteins are ideally placed to control the dynamics and balance of activation of concurrent signalling pathways.
Mining for petroleum: feasibility study. Final open file report Mar 1977-Jul 1978 (1978)

Two potential modified in situ methods are described for recovering the 68 pct 'unrecoverable' hydrocarbons in oil reservoirs. For the 300 billion barrels of conventional light crude a drip drainage system is suggested by mining underneath a reservoir and producing from below by controlled gravity flow. For the 200 billion barrels of heavy or viscous oil and tar sands deposits, a flip flop process is described using surface flooding with hot water saturated with surfactant and weighting additives. Mining engineering description of shafts and tunnels required are included as is a discussion of the tunnel proximity to a reservoir. Petroleum engineering flow equations to describe production rates and candidate reserve areas of the United States are described.
Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis (2010)

The DM domain proteins Doublesex- and MAB-3-related transcription factors (DMRTs) are widely conserved in metazoan sex determination and sexual differentiation. One of these proteins, DMRT1, plays diverse and essential roles in development of the vertebrate testis. In mammals DMRT1 is expressed and required in both germ cells and their supporting Sertoli cells. Despite its critical role in testicular development, little is known about how DMRT1 functions as a transcription factor or what genes it binds and regulates. We combined ChIP methods with conditional gene targeting and mRNA expression analysis and identified almost 1,400 promoter-proximal regions bound by DMRT1 in the juvenile mouse testis and determined how expression of the associated mRNAs is affected when Dmrt1 is selectively mutated in germ cells or Sertoli cells. These analyses revealed that DMRT1 is a bifunctional transcriptional regulator, activating some genes and repressing others. ChIP analysis using conditional mutant testes showed that DNA binding and transcriptional regulation of individual target genes can differ between germ cells and Sertoli cells. Genes bound by DMRT1 in vivo were enriched for a motif closely resembling the sequence DMRT1 prefers in vitro. Differential response of genes to loss of DMRT1 corresponded to differences in the enriched motif, suggesting that other transacting factors may modulate DMRT1 activity. DMRT1 bound its own promoter and those of six other Dmrt genes, indicating auto- and cross-regulation of these genes. Many of the DMRT1 target genes identified here are known to be important for a variety of functions in testicular development; the others are candidates for further investigation.
Coconut-Water-Mediated Carbonaceous Electrode: A Promising Eco-Friendly Material for Bifunctional Water Splitting Application (2021)

The organic and eco-friendly materials are extended to prevail over the worldwide energy crisis where bio-inspired carbonaceous electrode materials are being prepared from biogenic items and wastes. Here, coconut water is sprayed over three-dimensional (3D) nickel foam for obtaining a carbonaceous electrode material, i.e., C@Ni-F. The as-prepared C@Ni-F electrode has been used for structural elucidation and morphology evolution studies. Field emission scanning electron microscopy analysis confirms the vertically grown nanosheets of the C@Ni-F electrode, which is further employed in the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER), where excellent OER and HER performances with small overpotentials of 219 and 122 mV and with stumpy Tafel slopes, i.e., 27 and 53 mV dec<sup>-1</sup>, are respectively obtained, suggesting a bifunctional potential of the sprayed electrode material. Moreover, sustainable bifunctional performance of C@Ni-F proves considerable chemical stability and moderate mechanical robustness against long-term operation, suggesting that, in addition to being a healthy drink to mankind, coconut water can also be used for water splitting applications.
Single‐Crystal Multilayer Nitride, Metal, and Oxide Structures on Engineered Silicon for New‐Generation Radio Frequency Filter Applications (2020)

Molecular beam epitaxy is used for growth of structures with ScAlN for radio frequency filter applications. The nitride layers are grown directly on Si substrates for surface acoustic wave resonators, Lamb acoustic wave resonators, and on an epitaxial Mo on Er 2 O 3 buffer layer on Si for film bulk acoustic resonators (FBARs). The crystal structure of the ScAlN layer is defined by Sc concentration. It can vary from wurtzite to hexagonal. Good crystal quality of the Mo layer results in low sheet resistance which is very close to that of the bulk material. Enhanced electroacoustic performance is achieved in fabricated acoustic devices. A Lamb acoustic wave resonator with ScAlN grown directly on Si demonstrates a high coupling factor (4.8%) and figure of merit ( Q × k t 2 ) (9.1) at a resonance frequency of 9.02 GHz. A fundamental resonance frequency 4.32 GHz is achieved for an FBAR device fabricated using the structure with the nitride layer on an epitaxial metal electrode. At the 4.32 GHz resonance frequency, the extracted figure of merit of the resonator is 10.6.
Inherited dup(17)(p11.2p11.2): Expanding the phenotype of the Potocki–Lupski syndrome (2013)

Potocki-Lupski syndrome (PTLS, OMIM: 610883) is a microduplication syndrome characterized by infantile hypotonia, failure to thrive, cardiovascular malformations, developmental delay, intellectual disability, and behavior abnormalities, the latter of which can include autism spectrum disorder. The majority of individuals with PTLS harbor a de novo microduplication of chromosome 17p11.2 reciprocal to the common recurrent 3.6 Mb microdeletion in the Smith-Magenis syndrome critical region. Here, we report on the transmission of the PTLS duplication across two generations in two separate families. Individuals in these families presented initially with developmental delay, behavior problems, and intellectual disability. We provide a detailed review of the clinical and developmental phenotype of inherited PTLS in both families. This represents the second report (second and third families) of PTLS in a parent-child pair and exemplifies the under-diagnosis of this and likely other genetic conditions in adults with intellectual disability and/or psychiatric disorders.
Regulation of intracellular free calcium in normal murine keratinocytes (1991)

Cultured normal murine keratinocytes maintain a basal cell phenotype in medium with a Ca2+ concentration of 0.05 mM and differentiate when exposed for 28-48 h to medium supplemented with extracellular Ca2+ greater than 0.10 mM. Previous studies have documented Ca2+ activation of signaling pathways in the plasma membrane and tightly regulated cellular responses to small incremental changes in extracellular Ca2+. To determine if changes in free cytosolic calcium (Cai) are associated with these early signaling events, digital image analysis of fura-2-loaded keratinocytes was used to measure Cai in individual cells. Basal keratinocytes in 0.05 mM Ca2+ display a biphasic Cai increase when exposed to greater than 0.1 mM Ca2+ in serum-containing medium. These separate phases were controlled by different media components. Initial peak Cai occurred rapidly (within 60 s), was transient (lasting less than 5 min), and resulted from release of 10-20% of total intracellular Ca2+ stores. Peak Cai depended on serum concentration and was independent of extracellular Ca2+. This transient Cai response was lost as keratinocytes differentiated. Plateau Cai level was sustained (greater than 24 h) and depended on extracellular Ca2+, but not serum. The magnitude of plateau Cai increased incrementally following increases in extracellular Ca2+ as small as 0.02 mM. A similar biphasic Cai increase was noted in cultures of murine dermal fibroblasts stimulated by 1.2 mM Ca2+ and serum. However, fibroblasts did not lose the serum response in high-Ca2+ medium, and plateau Cai was not sensitive to small changes in extracellular Ca2+.(ABSTRACT TRUNCATED AT 250 WORDS)
ChemInform Abstract: First Enantioselective Total Synthesis of a Naturally Occurring Dolabellane. Revision of Absolute Configuration. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Modeling a Full Scale Landslide Test (2011)

The power of the finite element analysis method is clearly demonstrated in this case study. Finite element analysis was used to evaluate the Platepile method for stabilizing shallow landslides. The Platepile Method consists of the installation of arrays of steel elements driven vertically into the slope at spacing of 1 meter (4 feet) horizontally and 1 to 3 meters (4 to 10 feet) up and down the slope. A field testing program included full scale landslide tests. Finite element modeling predicted the maximum layer that could be stabilized by 2 meters (6 feet) long. A second full scale field test was performed to validate the effectiveness of the method for the maximum predicted layer thickness. The following discussion describes the Platepile method, the program for testing the validity of the concept and the use of finite element modeling to develop numerous varying configurations of slope conditions and soil parameters.
Synthesis and CYP24A1-Dependent Metabolism of 23-Fluorinated Vitamin D3 Analogues (2019)

Two novel 23-fluorinated 25-hydroxyvitamin D<sub>3</sub> analogues were synthesized using Inhoffen-Lythgoe diol as a precursor of the CD-ring, efficiently. Introduction of the C23 fluoro group was achieved by the deoxy-fluorination reaction using <i>N</i>,<i>N</i>-diethylaminosulfur trifluoride or 2-pyridinesulfonyl fluoride (PyFluor). Kinetic studies on the CYP24A1-dependent metabolism of these two analogues revealed that (23<i>S</i>)-23-fluoro-25-hydroxyvitamin D<sub>3</sub> was more resistant to CYP24A1-dependent metabolism than its 23<i>R</i> isomer.
New Directions In DSP From Texas Instruments (2005)

This paper describes what Texas Instruments is doing to provide further advances in the three areas of market direction. The paper details how the company has, in the past, made advancements and suggests some future ideas under consideration. Please note that the future ideas, discussed in this paper, are speculative in nature and therefore none of these ideas should be construed as a plan to develop or offer any product or service by Texas Instruments. The future ideas sections are in italics. Please interpret these accordingly.
The Role of Animal Models for Research on Severe Malaria (2012)

In light of the recent controversies over the role of animal models for research into the development of new treatments for severe malaria, particularly cerebral disease, a group of scientists came together to discuss the relative merits of a range of animal models and their overlap with the complex clinical syndromes of human disease. While it was not possible to fully resolve differences over the utility of the Plasmodium berghei ANKA model of experimental cerebral malaria, the meeting did bring the two research communities closer together to identify further work to provide information needed to validate the model and revitalise the development of other animal models displaying features of human pathology. The driving force behind this was the desire to ensure better translation of experimental findings into effective treatments for severe malaria.
Impact of mask absorber on EUV imaging performance (2010)

EUVL requires the use of reflective optics including a reflective mask. The reticle blank contains a reflecting multilayer, tuned for 13.5nm actinic light, and an absorber which defines the dark areas. The oblique incidence of light in combination with the small wavelength in comparison to the mask topography causes a number of effects which are unique to EUV, such as an H-V CD offset and an orientation dependent pattern placement error. These so-called shadowing effects can be mitigated by a smart choice of materials and thicknesses in the absorber stack. In this paper we will provide a comparison of the imaging performance of three reticles with different mask absorber stacks exposed on ASML's two alpha demo tools. We will focus on the imaging performance of 32nm L/S through pitch. Not only is the impact of the mask absorber stack on shadowing evaluated, but also on process windows and MEEF. The experimental data is compared to simulations to support the observations and to provide a more in-depth analysis of the impact of the various layers in the mask stack on CDU at wafer level. The results will be used to estimate the impact on CDU performance of the NXE:3x00 for 27 and 22nm node applications, providing guidance for mask manufacturing for HVM process development.
Expression of Amplified cDNA Sequences Encoding Human Interleukin 2 in Human Cells (1987)

Expression of human interleukin 2 (IL-2) at high levels has been achieved in human cells by cotransfection and subsequent coamplification of the transfected sequences. IL-2 production by these cells reached 2700 U/ml of culture medium. This productivity was higher than the 100U/ml attained by concanavalin A (ConA) stimulated human leukaemic Jurkat, T cells. A plasmid, pSDI, containing human IL-2 cDNA and mouse dihydrofolate reductase (DHFR) cDNA was con-structed, and cotransfected with plasmid pSV2neo at a 10:1 molar ratio, into Hela (human epitheloid carcinoma) cells by the DNA-calcium phosphate coprecipitation technique. Transformants producing IL-2 were easily obtained among antibiotic G418 resistant colonies. Cells resistant to increased levels of methotrexate (MTX) secreted a large amount of IL-2 as a result of coamplification of DHFR cDNA and IL-2 cDNA. Expression of IL-2 cDNA was stimulated by removing a G-C stretch which was present between Simian Virus 40 (SV40) early promoter and IL-2 cDNA. Plasmid pSDI was rescued from the transformed Hela cells and shown to be present in the intact form among the amplified cellular DNA.
Processing and 3D printing of SiCN polymer‐derived ceramics (2021)

Abstract Preceramic polymer resins are attractive for the 3D printing of net‐shaped ceramic components. Recently various processes have been demonstrated for 3D printing of polymer‐derived ceramics (PDCs). Ultimately in these processes, the process outcomes strongly depend on the process parameters. In particular, for PDCs the ceramic density, and ceramic yield are affected by the catalyst concentration and cross‐linking duration. Here, we use thermal analysis and FTIR to quantify the interrelation of the process parameters on the process outcome for polysilazanes and demonstrate 3D printing of PDC components based on the best‐identified process parameters. The results of this work can be used as guidelines for future additive manufacturing of PDCs.
Exponential improvement of the sign problem via contour deformations in the 2+1D XY model at non-zero density (2022)

We studied the 2+1 dimensional XY model at nonzero chemical potential on deformed integration manifolds with the aim of alleviating its sign problem. We investigated several proposals for the deformations and managed to considerably improve on the severity of the sign problem with respect to standard reweighting approaches. In this talk I present numerical evidence that a significant reduction of the sign problem can be achieved which is exponential in both the squared chemical potential and the spatial volume. Furthermore, I discuss a new approach to the optimizaiton procedure, based on reweighting, that sensibly reduces its computational cost.