gebhart/patrepeval huggingface dataset:
NATURAL POLYMER VIS A VIS SYNTHETIC POLYMER FOR SOLUBILITY ENHANCEMENT OF SIMVASTATIN (2012)

The enhancement of the oral bioavailability is currently one of the greatest challenges in the development of poorly water soluble drugs. The main objective of work to enhance solubility of Simvastatin (SIM) by use of natural polymer, chitosan (CHI) and Hydroxy propyl methyl cellulose E3LV (HPMCE3LV), synthetic polymer to produce cost effective formulation. Physical mixture, co-grinding method, spray drying method are compared .Co-grinding method applied for preparation of drug polymer complex and compared with the solubility and dissolution of marketed preparation.
Inducing and Administering Tregs to Treat Human Disease (2016)

Regulatory T cells (Tregs) control unwanted immune responses, including those that mediate tolerance to self as well as to foreign antigens. Their mechanisms of action include direct and indirect effects on effector T cells and important functions in tissue repair and homeostasis. Tregs express a number of cell surface markers and transcriptional factors that have been instrumental in defining their origins and potentially their function. A number of immune therapies, such as rapamycin, IL-2, and anti-T cell antibodies, are able to induce Tregs and are being tested for their efficacy in diverse clinical settings with exciting preliminary results. However, a balance exists with the use of some, such as IL-2, that may have effects on unwanted populations as well as promoting expansion and survival of Tregs requiring careful selection of dose for clinical use. The use of cell surface markers has enabled investigators to isolate and expand ex vivo Tregs more than 500-fold routinely. Clinical trials have begun, administering these expanded Tregs to patients as a means of suppressing autoimmune and alloimmune responses and potentially inducing immune tolerance. Studies in the future are likely to build on these initial technical achievements and use combinations of agents to improve the survival and functional capacity of Tregs.
A Linearized, Time Dependent Model of the Heat Transfer and Thermoregulatory Responses Occurring upon Immersion in Cold Water (1982)

Abstract : Twenty males subjects (17 to 28 yrs of age) exhibiting a range of body weights (60 less than or = BW less than or = 95 Kg) and body fat (7% less than or = BF less than or = 23%) underwent total immersion while at rest in water between 36 C and 20 C. Their metabolic heat production, which were measured as functions of time and water temperature, were converted to explicit linear functions of core (T sub re) and skin (T sub s) temperatures for each individual immersion. These were used to define planes of thermogenic activity which allowed the comparison of the onset and magnitude of shivering between individuals of any morphological group. These thermogenic planes show too much steeper slope with respect to the T sub s axis for small, thin men than for heavy, fat men, while men of average weight and fat composition exhibit an intermediate slope. Small, lean men also appear to exhibit thermogenic planes having steeper slopes with respect to the T sub re axis than do average and heavy men. Analysis showed that both metabolic and cardiovascular compensation occurs at higher bath temperatures for small, lean men than heavy fat men. It also showed that body size is more important than body fat content alone in determining maximal total internal insulation. The analysis showed that clothing can lower core temperature rather than elevate it, particularly for some heavy subjects by increasing internal conductances and lowering heat production. This occurs in the face of a net increase in external insulation.
Nucleoside 3'-phosphotriesters as key intermediates for the oligoribonucleotide synthesis. IV. New method for removal of 2,2,2-trichioroethyl group and31NMR as a new tool for analysis of deblocking of intemucleotide phosphate protecting groups (1977)

Een wetenschappelijke satellite van ESA is gelanceerd, voorheen XMM genoemd en na de lancering "Newton"genoemd. De satellite is nog steeds in werking en heeft een interessant instrument met een lens system bestaande uit coaxiale cylindrische spiegels. Laatstgenoemde reflectoren focusseren de binnenkomende Rontgen stralen in een "grazing incidence"(anders gaat Rontgen straling door het material heen). Nadat een bedrijf (Media-Lario) dit soort coaxiale reflector system ontwikkeld en gebouwd hat , was het noodzakelijk om te zien of zulke hoogwaardige technologie niet voor wat anders gebruikt kon worden. Hieruit is een ontwikkeling voortgekomen om deze technologie te gebruiken voor antennes op de grond. Daaruit is een panel technologie voort gekomen (voor het eerst hierop aangestuurd door de auteur in 1999 in Astron) voor de ALMA radio telescoop antennes. Het heft tot interessante samenwerking geleid met ESO, met Dr. J. Baars die direct de positieve resultaten er van inzag). Genoemde technologie is nu terug te vinden op 25 radio telescoop antennes in het ALMA system van 50+16 radio telescopen.
Control design of a safety restraint system (2002)

In this paper, a numerical tool for the design of controllers each representing an actuator of a smart safety restraint sys-tem, is introduced. The airbags are left out of consideration. The focus is on the design of a controller for the chest ac-celeration of the driver by manipulating the force applied to the belt by the beltforce limiter. The tool is based on local linearizations of the non-linear transfer of the manipulated variable (the beltforce) to the controlled variable (the chest acceleration). Local linearizations are performed at equidis-tant time points during a crash in order to check time invari-ancy and using perturbations with different magnitudes in order to check linearity of the transfer. The identified linear model is used to design a PID controller. For an evalua-tion of the outlined approach, the controller is applied to the (non-linear) model of the US-NCAP crash test, designed in the multibody and finite element package MADYMO. Re-sults for this case are presented and future research topics are indicated. 1
Nanoshell Magnetic Resonance Imaging Contrast Agents (2007)

Nanocontrast agents have great potential in magnetic resonance (MR) molecular imaging applications for clinical diagnosis. We synthesized Au(3)Cu(1) (gold and copper) nanoshells that showed a promising MR contrast effect. For in vitro MR images, the large proton r1 relaxivities brightened T(1)-weighted images. As for the proton-dephasing effect in T(2), Au(3)Cu(1) lightened MR images at the low concentration of 0.125 mg mL(-1) (3.84 x 10(-7) mM), and then the signal continuously decreased as the concentration increased. For in vivo MR imaging, Au(3)Cu(1) nanocontrast agents enhanced the contrast of blood vessels and suggested their potential use in MR angiography as blood-pool agents. We propose that (1) the cooperativity originating from the form of the nanoparticles and (2) the large surface area coordinated to water from their porous hollow morphology are important for efficient relaxivity. In a cytotoxicity and animal survival assay, Au(3)Cu(1) nanocontrast agents showed a dose-dependent toxic effect: the viability rate of experimental mice reached 83% at a dose of 20 mg kg(-1) and as much as 100% at 2 mg kg(-1).
Neurofilament light chain (2015)

This report provides Class III evidence that the NfL electrochemiluminescence immunoassay accurately distinguishes patients with sporadic ALS from healthy controls.
Implementation of an integrated multispecialty poison-control centre in Bangalore, India: results of a pilot implementation (2017)

BackgroundPoisoning accounts for 30% of suicides in India and accidental and environmental exposures to poisons are frequent. The most common poisonings in India involve insecticides, rodenticides, snakebites, alcohols, sedative hypnotics, opioids, and pain medication. In India in 2017, a few poison information centres exist, but there is no regional integrated poison control and information centre that can be readily accessed by people in the community, where poisonings occur. Here, we describe the implementation of a multispecialty model for an integrated regional poison-control centre in the city of Bangalore, Karnataka.MethodsWe developed a model for a poison control centre that includes specialists from emergency medicine, critical care, pharmacology, paediatrics, psychiatry, preventive medicine, and laboratory diagnostics. The centre provides referral and management advice for poisonings, drug information, psychosocial care with suicide prevention, forensic medicine, and poison education for the general public. Patients are initially treated and stabilised at peripheral hospitals and then transferred by paramedics to a toxicology centre of excellence, or hospital, for poisoning consultation, intensive care management, enhanced elimination measures, and antidote therapy. Computerised software treatment modules have been developed for the most common poisonings for use by health-care providers in other hospitals in Bangalore.FindingsIn 2016, a toxicology centre of excellence was established at the MS Ramaiah Memorial Hospital and Medical College, a major metropolitan hospital in Bangalore, and linked with five peripheral hospitals in Karnataka. The central hospital provides all-hours, low-cost comprehensive poisoning information software and treatment protocols, forensic toxicology testing, reference laboratory analysis, Hazmat decontamination, intensive care management, and an antidote depot for peripheral hospitals.InterpretationAn integrated multispecialty poison control system has been established for the treatment of poisoning in one defined area of a major metropolitan region in India. The project provides poisoning information and a referral system to other surrounding metropolitan hospitals and will soon be rolled out to the entire city of Bangalore (population 10 million people). In response to findings from this pilot phase, we have added more software modules to include treatment of the most commonly encountered poisons. In response to the high rate of intentional poisonings, a suicide prevention and referral centre is being developed and will be located in the same building as the poison control centre. The next phase of the project will include a mobile telecommunications service to the general public in Karnataka (population 65 million). This system of care could be adopted as a model for other states in India to provide affordable, life-saving poison control information, toxicology surveillance, treatment, referral, and poisoning prevention.FundingMS Ramaiah University.
Silica accelerates the selective hydrogenation of CO2 to methanol on cobalt catalysts (2020)

The reaction pathways on supported catalysts can be tuned by optimizing the catalyst structures, which helps the development of efficient catalysts. Such design is particularly desired for CO<sub>2</sub> hydrogenation, which is characterized by complex pathways and multiple products. Here, we report an investigation of supported cobalt, which is known for its hydrocarbon production and ability to turn into a selective catalyst for methanol synthesis in CO<sub>2</sub> hydrogenation which exhibits good activity and stability. The crucial technique is to use the silica, acting as a support and ligand, to modify the cobalt species via Co‒O‒SiO<sub>n</sub> linkages, which favor the reactivity of spectroscopically identified *CH<sub>3</sub>O intermediates, that more readily undergo hydrogenation to methanol than the C‒O dissociation associated with hydrocarbon formation. Cobalt catalysts in this class offer appealing opportunities for optimizing selectivity in CO<sub>2</sub> hydrogenation and producing high-grade methanol. By identifying this function of silica, we provide support for rationally controlling these reaction pathways.
L-Asparagine (2007)

Crystals of anhydrous l-aspargine, C4H8N2O3, were obtained from a saturated aqueous solution. The mol­ecules are in their zwitterionic form. Although the carboxyl group is deprotonated, the distances of the two C O bonds are significantly different [1.2407 (19) and 1.262 (2) Å], due to different hydrogen-bond environments. The conformation of the side chain is trans, which distinguishes it significantly from that of l-asparagine monohydrate.
IL-9 protects against bleomycin-induced lethal lung injury through a prostaglandin-dependent mechanism. (2004)

IL-9 is a Th2 cytokine that exerts pleiotropic activities, and might be involved in the regulation of lung inflammatory processes. To characterize the activity of IL-9 on lung injury, we compared the pulmonary responses to bleomycin (blm) in IL-9 transgenic (Tg5) and wild-type (FVB) mice. Following intratracheal instillation of lethal doses of blm, the mortality rate was markedly reduced in Tg5 mice compared to their wild-type counterparts (ie, 25% mortality for Tg5 versus 85% for FVB mice, 21 days after instillation of 0.05U blm/mouse). Histological and biochemical analyses showed that blm induced less lung injury and less epithelial damage in Tg5 as compared to FVB animals. This protection of Tg5 mice was accompanied by an expansion of eosinophils and B cells in the lungs. In addition, TGF-beta and prostaglandin-E2 (PGE2) levels in broncho-alveolar lavage fluid were also increased in transgenic mice. The contribution of B cells and eosinophils to the protective mechanism did not appear essential since eosinophil-deficient (IL-5 KO) and B-deficient (muMT) mice overexpressing IL-9 were also resistant to high doses of blm. We could rule out that TGF-beta was a key factor in the protective effect of IL-9 by blocking this mediator with neutralizing antibodies. Indomethacin treatment, which inhibited PGE2 production in both strains, suppressed the protection in Tg5 mice, supporting the idea that IL-9 controls blm-induced lung injury through a prostaglandin-dependent mechanism.
Results from the First Full Scale Wind Turbine Equipped with Trailing Edge Flaps (2010)

The following paper describes a part of an experimental work carried out in the research project ATEF. This project is a collaboration between Vestas Wind Systems A/S, Riso DTU and DTU Technical University of Denmark. The aim of the project is to test and validate trailing edge flap systems for load alleviation for wind turbines. The present work covers the first measurements of a trailing edge system ever to be carried out on a full scale turbine. The measurements and the potential load reduction are compared to simulations using aeroelastic tools. These aeroelastic models are tuned to the measurements without flaps. The results show a good agreement between measurements and simulations.
Defect Engineering of Chalcogen‐Tailored Oxygen Electrocatalysts for Rechargeable Quasi‐Solid‐State Zinc–Air Batteries (2017)

A critical bottleneck limiting the performance of rechargeable zinc-air batteries lies in the inefficient bifunctional electrocatalysts for the oxygen reduction and evolution reactions at the air electrodes. Hybridizing transition-metal oxides with functional graphene materials has shown great advantages due to their catalytic synergism. However, both the mediocre catalytic activity of metal oxides and the restricted 2D mass/charge transfer of graphene render these hybrid catalysts inefficient. Here, an effective strategy combining anion substitution, defect engineering, and the dopant effect to address the above two critical issues is shown. This strategy is demonstrated on a hybrid catalyst consisting of sulfur-deficient cobalt oxysulfide single crystals and nitrogen-doped graphene nanomeshes (CoO<sub>0.87</sub> S<sub>0.13</sub> /GN). The defect chemistries of both oxygen-vacancy-rich, nonstoichiometric cobalt oxysulfides and edge-nitrogen-rich graphene nanomeshes lead to a remarkable improvement in electrocatalytic performance, where CoO<sub>0.87</sub> S<sub>0.13</sub> /GN exhibits strongly comparable catalytic activity to and much better stability than the best-known benchmark noble-metal catalysts. In application to quasi-solid-state zinc-air batteries, CoO<sub>0.87</sub> S<sub>0.13</sub> /GN as a freestanding catalyst assembly benefits from both structural integrity and enhanced charge transfer to achieve efficient and very stable cycling operation over 300 cycles with a low discharge-charge voltage gap of 0.77 V at 20 mA cm<sup>-2</sup> under ambient conditions.
A Cosmology Founded on Intrinsic Attributes of Consciousness (2019)

A cosmology grounded in consciousness is described that accounts for well-known but inexplicable phenomena such as near-death and out-of-body experiences, telepathy, remote viewing, and materialization. Configurations of the energy of consciousness are distinguished by the multidimensional property of vibration. Attributes of consciousness include the intrinsic processes of creation and perception. Human and other intelligent beings are self-aware configurations of consciousness and may have independent experiences. A being experiences matter when configurations of consciousness are transformed to sensations by the perceptual process. The cosmology offers new insights into what is possible.
Agent Technologies Designed to Facilitate Interactive Knowledge Construction (2008)

During the last decade, interdisciplinary researchers have developed technologies with animated pedagogical agents that interact with the student in language and other communication channels (such as facial expressions and gestures). These pedagogical agents model good learning strategies and coach the students in actively constructing knowledge during learning. This article describes computer technologies that have been developed during the last decade with tutors that attempt to facilitate deep comprehension (e.g., causal explanations, plans, logical justifications), reasoning in natural language, and inquiry (i.e., question asking, question answering, hypothesis testing). These tutors target high school and college students who learn about topics in science and technology. The primary example is AutoTutor, a system on the Internet that helps students compose answers to deep-reasoning questions and solutions to problems by holding a conversation. AutoTutor's dialogue moves include feedback (positive, neutral, and negative), pumps for more information (“Tell me more.”), hints, prompts to fill in missing words, summaries, corrections of student misconceptions, and answers to student questions. Other learning technologies with agents include the Human Use Regulatory Affairs Advisor (HURAA); Source, Evidence, Explanation, and Knowledge (SEEK) Web Tutor; Interactive Strategy Trainer for Active Reading and Thinking (iSTART); Instruction with Deep-level Reasoning questions In Vicarious Environments (iDRIVE); and Acquiring Research Investigative and Evaluative Skills (ARIES). These systems have been tested on their effectiveness in facilitating knowledge construction. They also have uncovered insights on the prospects of designing agents to effectively communicate in language and discourse.
ChemInform Abstract: Application of the Asymmetric Chelate Enolate Claisen Rearrangement to the Synthesis of Unsaturated Polyhydroxylated Amino Acids. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optimal Design and Control (1995)

Workshop on Optimal Design and Control (1994 : Blacksburg, VA)Optimal design and control : proceedings of the workshop onOptimal Design and Control, Blacksburg, Virginia, April 8-9, 1994 /Jeffrey Borggaard...[et ah], editors.p. cm. - (Progress in systems and control theory ; v. 19)Includes bibliographical references.ISBN 0-8176-3808-3 (acid-free paper).1. Automatic control—Congresses. 2. Mathematical optimization--Congresses. I. Borggaard, Jeffrey, 1964- . 0. Title.III. Series.TJ212.W675 1994 95-10230629.8~dc20 CIPPrinted on acid-free paper© 1995 Birkhauser Boston
Linking to Web Knowledge Bases and Applications to Web Search (2014)

The development and availability of Web knowledge repositories, in particular Wikipedia, as the largest, inter-linked, and up-to-the-minute encyclopedic collection, have changed remarkably not only the way in which people fulfill their informational needs on the Web but also the way in which information can be organized and provided by Web search engines. The talk will focus on the task of entity extraction and linking to Wikipedia and other Web knowledge repositories. It will also cover work that employs such entity repositories in conjunction with query logs of commercial Web search engines to address Web information retrieval tasks such as context-aware search, query suggestion, question answering, retrieval of support for factual statements, and automatic aggregation of topic pages as an alternative to the ten blue links.
Random and partially random acoustic arrays (1978)

J. C. Lockwood Computer Sciences Corporation, 2251 San Diego Avenue, San Diego, CA 92110 Statistical properties of the beampatterns of three-dimensional random arrays of arbitrary geometry are derived. The class of random arrays studied differs from those previously analyzed in that it includes partially random arrays. A partially random array is defined, for purposes of this paper, as an array in which the element positions are random variables subject to constraints that create some degree of either non-randomness or interdependence. An example of a partially random array is an array in which several hydrophones are suspended in each of a large number of vertical strings. The elements are all randomly positioned, but the elements in each string lack independence in their horizontal positions. A methodology for analyzing partially random arrays is developed in which the full array is decomposed into a number of subarrays. The subarrays are chosen so that the element positions of each are independent and have the same probability density function. The properties of the random subarrays are combined to yield expressions for the expected value and variance of the pattern function of the composite partially random array. The expected value of the directivity index is also given in terms of the pattern function statistics. [Work supported by the Naval Ocean Systems Center.]
Preliminary studies of the enhanced electrochemiluminescence of 2,3-diaminonaphthalene in the presence of specific metal ions (1998)

Electrochemiluminescence (ECL) of 200 ppm 2,3-diaminonaphthalene (2,3-DAN) was studied alone and in conjunction with 100 ppm of 34 different metal and non-metal ions and revealed three relatively intense ECL responses from interactions of 2,3-DAN with Au+, Fe+3 and V+5. ECL responses from Cr+6 or Ru+3 with 2,3-DAN were less intense, but noteworthy, as was the coloured fluorescent product of the non-metal ion Se+4 interaction with 2,3-DAN. Several intense 2,3-DAN-metal ion ECL reactions were studied in greater detail and revealed various titration curves with ionic detection limits in the low ppm range, using a fixed level (200 ppm) of 2,3-DAN.