gebhart/patrepeval huggingface dataset:
Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. (1995)

The RBTN2 LIM-domain protein, originally identified as an oncogenic protein in human T-cell leukemia, is essential for erythropoiesis. A possible role for RBTN2 in transcription during erythropoiesis has been investigated. Direct interaction of the RBTN2 protein was observed in vivo and in vitro with the GATA1 or -2 zinc-finger transcription factors, as well as with the basic helix-loop-helix protein TAL1. By using mammalian two-hybrid analysis, complexes involving RBTN2, TAL1, and GATA1, together with E47, the basic helix-loop-helix heterodimerization partner of TAL1, could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis, and the data suggest that variations in amounts of complexes involving RBTN2, TAL1, and GATA1 could be important for erythroid differentiation.
Forskning viser vejen for fremtidens spildevandssystemer (2008)

Artiklen beskriver et nyt forskningsprojekt "Storm- and Wastewater Informatics" der over de næste 5 år vil udforske og udvikle muligherne for optimering af afløbs- og spildevandssystemet som helhed. Resultaterne af forskningsprojektet vil være tilgængeligt for alle kommuner og forsyninger.
Mariner Mars 1971 battery design, test, and flight performance (1973)

The design, integration, fabrication, test results, and flight performance of the battery system for the Mariner Mars spacecraft launched in May 1971 are presented. The battery consists of 26 20-Ah hermetically sealed nickel-cadmium cells housed in a machined magnesium chassis. The battery package weighs 29.5 kg and is unique in that the chassis also serves as part of the spacecraft structure. Active thermal control is accomplished by louvers mounted to the battery baseplate. Battery charge is accomplished by C/10 and C/30 constant current chargers. The switch from the high-rate to low-rate charge is automatic, based on terminal voltage. Additional control is possible by ground command or onboard computer. The performance data from the flight battery is compared to the data from various battery tests in the laboratory. Flight battery data was predictable based on ground test data.
Free-space–fiber hybrid distributed optical cross-connect interconnect module (1999)

We propose implementing a large-scale optical cross-connect network based on a free-space-fiber hybrid interconnect system. The free-space portion of the system is designed to handle shuffle operation of optical beams that need to intersect each other. The fiber portion is used to guide these signals to and from optical transceivers, which can be distributed at different locations. A compact and packaged prototype that handles 256x256 input-output channels is demonstrated.
Perfect Chirped Echelle Grating Wavelength Multiplexor: Design and Optimization (2013)

A new method for designing an echelle-type diffraction grating for wavelength division multiplexing (WDM), which is tuned to a single stigmatic point, is introduced. The new grating is defined by the mode and wavelength of operation in a slab waveguide, the position of the waveguides, the order of diffraction, and an arbitrary path, which is called the grating line, upon which individual facets are positioned, blazed, and curved via the outlined algorithm. A systematic design process for echelle gratings (EGs) is presented, covering all the key aspects of this device. A series of rules to improve the performance of any EG WDM device is outlined. A simulated comparison between this device, a standard Rowland grating, and a two stigmatic point grating, was undertaken with the new design performing better and comparably in each case, respectively.
Genomics-guided drawing of malignant regulatory signatures revealed a pivotal role of human stem cell-associated retroviral sequences (SCARS) and functionally-active hESC enhancers (2020)

From patients and physicians perspectives, the clinical definition of a tumor malignant phenotype could be restricted to the early diagnosis of sub-types of malignancies with the increased risk of existing therapy failure and high likelihood of death from cancer. It is the viewpoint from which the understanding of malignant regulatory signatures is considered in this contribution. Analyses from this perspective of experimental and clinical observations revealed the pivotal role of human stem cell-associated retroviral sequences (SCARS) in the origin and pathophysiology of clinically-lethal malignancies. SCARS represent evolutionary- and biologically-related family of genomic regulatory sequences, the principal physiological function of which is to create and maintain the stemness phenotype during human preimplantation embryogenesis. SCARS expression must be silenced during cellular differentiation and SCARS activity remains silent in most terminally-differentiated human cells performing specialized functions in the human body. De-repression and sustained activation of SCARS result in differentiation-defective phenotypes, tissue- and organ-specific clinical manifestations of which are diagnosed as pathological conditions defined by a consensus of pathomorphological, molecular, and genetic examinations as the malignant growth. Contemporary evidence are presented that high-fidelity molecular signals of continuing activities of SCARS in association with genomic regulatory networks of thousands functionally-active enhancers triggering engagements of down-stream genetic loci may serve as both reliable diagnostic tools and druggable molecular targets readily amenable for diagnosis and efficient therapeutic management of clinically-lethal malignancies.
Performance of an inertially coupled, three-mode gravitational wave antenna prototype (1994)

A prototype three-mode gravitational wave antenna which employs a two-mode torsional transducer has been constructed and tested. For the torsional transducer the coupling from one stage to the next is via inertial forces, whereas in a conventional transducer the stage-to-stage coupling is proportional to the relative displacements via the springs. Experiments with our antenna-torsional transducer prototype demonstrate a maximum antenna bandwidth of 260 Hz (29% of the antenna resonant frequency of 900 Hz) and a mechanical amplification factor of 40. A mathematical model for the three-mode antenna has been developed and predictions of the system transfer functions and transient response are in close agreement with the measurements. Through the optimization of the transducer parameters we find that maximum fractional antenna bandwidths near 30% may be simultaneously achieved with mechanical amplification factors of 100 or more. Furthermore, the torsional transducer has a larger mechanical gain-antenna bandwidth product than a linear transducer with similar masses.
Fanconi syndrome-associated interstitial lung disease (2022)

A middle-aged man was referred to our respiratory department with dyspnoea progressively deteriorating and non-productive cough over the past 8 months. High-resolution CT revealed multiple bilateral consolidations, traction bronchiectasis, reticular pattern and honeycombing with basal and peripheral predominance. Serology tests were negative. Pulmonary function tests showed moderate restrictive functional impairment and severe reduction in diffusing capacity for carbon monoxide. Meticulous evaluation of patient's medical history revealed recent administration of oral corticosteroid due to pulmonary fibrosis potentially in the context of Fanconi syndrome diagnosed at childhood. The working diagnosis of interstitial lung disease (ILD) as a rare complication of Fanconi syndrome was proposed following multidisciplinary discussion. Despite combination treatment with low doses of corticosteroids and antifibrotic compound, the patient exhibited clinical, radiological and functional deterioration, was admitted to intensive care unit due to respiratory failure following infection-driven progression of fibrotic ILD and finally died.
Computer Network Intrusion Detection Technology (2011)

As an active intrusion detection security protection technology,intrusion detection provides internal attacks and external attacks and misuse of the real-time protection.Mainly expounds network intrusion and the basic concepts of intrusion detection.Introduces the current common intrusion detection technologies,and analyzes problems in intrusion detection system.At the same time,puts forward an intrusion detection model based on neural network BP algorithm for solving the existing problems.
Bone Marrow Tissue Engineering (2002)

The creation of mixed hematopoietic chimerism has become an important clinical strategy for tolerance induction for cellular and organ transplantation, and for the treatment of numerous hematopoietic diseases. Clinical success has been limited however, by host immune response and by competition from host hematopoiesis. Recent data suggests that limited donor stem cell engraftment after minimally myeloablative hematopoietic stem cell (HSC) transplantation may in part be due to MHC associated microenvironmental mismatch resulting in a competitive disadvantage for donor HSC. A strategy to overcome this barrier to stable mixed hematopoietic chimerism would involve concurrent transplantation of a donor bone marrow microenvironment. To test this possibility, we set out to develop a method to tissue engineer a bone marrow microenvironment. One to two murine femurs were mechanically crushed to a fine suspension and were combined in vitro with various delivery vehicles. These constructs were transplanted into syngeneic animals in locations that are known to support transplantation of other tissues. Although bone formation was observed with several conditions, bone marrow formation was noted only within the small bowel mesentery when type I collagen was used as the delivery vehicle. No bone marrow formed when the vehicle was changed to polyglycolic acid or type IV collagen. We have demonstrated that the small bowel mesentery can support bone marrow formation under specific in vivo conditions. Future work will focus on strategies for transplantation of an engineered donor bone marrow environment to facilitate creation of allogeneic mixed hematopoietic chimerism.
Corrections - Retention of the Oxygens at C-2 and C-3 of D-Ribulose 1,5-Biphosphate in the Reaction Catalyzed by Ribulose-1,5-biphosphate Carboxylase (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrections - Retention of the Oxygens at C-2 and C-3 of D-Ribulose 1,5-Biphosphate in the Reaction Catalyzed by Ribulose-1,5-biphosphate CarboxylaseJulia Sue and Jeremy KnowlesCite this: Biochemistry 1979, 18, 19, 4262Publication Date (Print):September 18, 1979Publication History Published online12 November 2003Published inissue 18 September 1979https://pubs.acs.org/doi/10.1021/bi00586a601https://doi.org/10.1021/bi00586a601research-articleACS PublicationsRequest reuse permissionsArticle Views10Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Testing the Mechanical Characteristics and Contacting Behaviour of Novel Manufactured and Assembled Sphere-Tipped Styli for Micro-CMM Probes (2014)

The effectiveness and versatility of the probes used on micro-co-ordinate measuring machines is currently limited by the dimensions, geometry and quality of the spherical stylus tips available. A shaft fabrication and gluing process is demonstrated to assemble a sphere-tipped stylus for tactile micro-co-ordinate measuring machine probes. The contact behaviour of the manufactured micro-styli is investigated both in a static and a vibrating mode. The ultimate strength of the glue joint is also investigated. It is concluded that the assembly of styli using the presented method is viable, however, that stylus shafts below 40 μm diameter may require new manufacturing methods.
XC- A language for embedded rule based systems (1987)

We report on experiences in the design of the programming language XC. It is an extension of C++ and combines abstract data types with rule based programming. Our design decisions are validated by three application prototypes and by benchmarking XC and OPS83. The experiences raise some critique on the RETE algorithm and on C++ as a host language. However, most of the results are also applicable to other host languages that support data abstraction. XC has been designed specifically to be used in embedded real-time expert systems.
Multilingual spoken-password based user authentication in emerging economies using cellular phone networks (2008)

Mobile phones are playing an important role in changing the socio-economic landscapes of emerging economies like India. A proper voice-based user authentication will help in many new mobile based applications including mobile-commerce and banking. We present our exploration and evaluation of an experimental set-up for user authentication in remote Indian villages using mobile phones and user-selected multilingual spoken passwords. We also present an effective speaker recognition method using a set of novel features called Compressed Feature Dynamics (CFD) which capture the speaker-identity effectively from the speech dynamics contained in the spoken passwords. Early trials demonstrate the effectiveness of the proposed method in handling noisy cell-phone speech. Compared to conventional text-dependent speaker recognition methods, the proposed CFD method delivers competitive performance while significantly reducing storage and computational complexity - an advantage highly beneficial for cell-phone based deployment of such user authentication systems.
Androgens and body composition in the aging male. (2005)

In February 1999 and May 2000, two workshops were held in Cortina, Italy and Montecarlo, respectively, to develop a consensus defining the diagnosis and treatment of acromegaly. The workshops were sponsored by the Italian Society of Endocrinology, the Pituitary Society and European Neuroendocrine Association. Partecipants from all over the world included endocrinologists, neurosurgeons and radiotherapists skilled in the management of acromegaly. This review paper summarizes the main points of the two consensus statements published following these two workshops.
Punctuation annotation using statistical prosody models. (2001)

This paper is about the development of statistical models of prosodic features to generate linguistic meta-data for spoken language. In particular, we are concerned with automatically punctuating the output of a broadcast news speech recogniser. We present a statistical finite state model that combines prosodic, linguistic and punctuation class features. Experimental results are presented using the Hub--4 Broadcast News corpus, and in the light of our results we discuss the issue of a suitable method of evaluating the present task. 1.
Enzymes as reagents in peptide synthesis: enzymatic removal of amine protecting groups. (1975)

A model system is described for the enzymatic deprotection of suitably masked amino groups during stepwise peptide synthesis. Nitrophenyl esters of amino acids, N-protected with trypsin-labile benzyloxycarbonylarginyl groups, were prepared as crystalline, analytically pure picrate salts in a standardized procedure. These intermediates were shown to react with amino compounds to form the expected peptide linkages. A pair of diasteriomeric peptides prepared in this way and featuring benzyloxycarbonylarginyl-L-, AND -D-glutaminyl sequences, respectively, were subjected to tryptic digestion. In both cases, a specific cleavage of the arginyl bond was achieved; however, the peptide containing the L-glutaminyl residue was deprotected much more rapidly than its diasteriomer containing the D-glutaminyl residue. The hydrolysis of the former isomer was not noticeably impeded by the presence of the latter. The results of these studies suggest that C-activated amino-acid derivatives, N-protected with trypsin-labile groups, are readily prepared in convenient form and that the peptide derivatives prepared from these intermediates are readily freed of their amino-protecting groups under mild, aqueous conditions with a potentially useful degree of stereospecificity. Theoretical implications of this first enzyme-catalyzed step in the repetitive cycle of peptide elaboration are discussed along with the procedural advantages implicit in the alternation of strongly and weakly basic groups in the protected and unprotected peptide intermediates, respectively.
Capacity-delay tradeoff for information dissemination modalities in wireless networks (2008)

This paper presents the first comprehensive capacity-delay tradeoff study for random wireless ad hoc networks under all information dissemination modalities (unicast, multicast, broadcast, anycast) when nodes operate either with multi-packet reception (MPR) or single-packet reception (SPR) capabilities. Our results demonstrate that for unicast, increasing capacity requires additional delay for SPR similar to the results in [1] while MPR incurs no penalty, i.e., we can increase capacity and decrease delay simultaneously for MPR. For multicast, there is no tradeoff for both SPR and MPR. However, similar tradeoff can be observed for broadcast when MPR is used while there is no tradeoff with SPR.
Minimally invasive aortic valve replacement versus aortic valve replacement through full sternotomy: the Brigham and Women's Hospital experience. (2015)

Our study confirms the clinical benefits of minimally invasive AVR via HS, which includes decreased transfusion requirements, ventilation times, intensive care unit and hospital length of stay without compromising short and long term survival compared to conventional AVR via FS.
Pooling morphometric estimates: a statistical equivalence approach (2015)

Changes in hardware or image processing settings are a common issue for large multi-center studies. In order to pool MRI data acquired under these changed conditions, it is necessary to demonstrate that the changes do not affect MRI-based measurements. In these circumstances classical inference testing is inappropriate because it is designed to detect differences, not prove similarity. We used a method known as statistical equivalence testing to address this limitation. Equivalence testing was carried out on three datasets: (i) cortical thickness and automated hippocampal volume estimates obtained from healthy individuals imaged using different multi-channel head coils; (ii) manual hippocampal volumetry obtained using two readers; and (iii) corpus callosum area estimates obtained using an automated method with manual cleanup carried out by two readers. Equivalence testing was carried out using the “two one-sided tests” (TOST) approach. Power analyses of the two one-sided tests were used to estimate sample sizes required for well-powered equivalence testing analyses. Mean and standard deviation estimates from the automated hippocampal volume dataset were used to carry out an example power analysis. Cortical thickness values were found to be equivalent over 61% of the cortex when different head coils were used (q &lt; 0.05, FDR correction). Automated hippocampal volume estimates obtained using the same two coils were statistically equivalent (TOST p = 4.28 × 10 -15 ). Manual hippocampal volume estimates obtained using two readers were not statistically equivalent (TOST p = 0.97). The use of different readers to carry out limited correction of automated corpus callosum segmentations yielded equivalent area estimates (TOST p = 1.28 × 10 -14 ). Power analysis of simulated and automated hippocampal volume data demonstrated that the equivalence margin affects the number of subjects required for well-powered equivalence tests. We have presented a statistical method for determining if morphometric measures obtained under variable conditions can be pooled. The equivalence testing technique is applicable for analyses in which experimental conditions vary over the course of the study.
C-terminal fragment of N-cadherin accelerates synapse destabilization by amyloid-β (2012)

The aetiology of Alzheimer's disease is thought to include functional impairment of synapses and synapse loss as crucial pathological events leading to cognitive dysfunction and memory loss. Oligomeric amyloid-β peptides are well known to induce functional damage, destabilization and loss of brain synapses. However, the complex molecular mechanisms of amyloid-β action resulting ultimately in synapse elimination are incompletely understood, thus limiting knowledge of potential therapeutic targets. Under physiological conditions, long-term synapse stability is mediated by trans-synaptically interacting adhesion molecules such as the homophilically binding N-cadherin/catenin complexes. In this study, we addressed whether inhibition of N-cadherin function affects amyloid-β-induced synapse impairment. We found that blocking N-cadherin function, both by specific peptides interfering with homophilic binding and by expression of a dominant-negative, ectodomain-deleted N-cadherin mutant, resulted in a strong acceleration of the effect of amyloid-β on synapse function in cultured cortical neurons. The frequency of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor-mediated miniature excitatory postsynaptic currents was reduced upon amyloid-β application much earlier than observed in controls. We further hypothesized that ectodomain-shed, transmembrane C-terminal fragments that are generated during N-cadherin proteolytic processing might similarly enhance amyloid-β-induced synapse damage. Indeed, expression of human N-cadherin C-terminal fragment 1 strongly accelerated amyloid-β-triggered synapse impairment. Ectodomain-shed N-cadherin C-terminal fragment 1 is further proteolytically cleaved by γ-secretase. Therefore, both pharmacological inhibition of γ-secretase and expression of the dominant-negative presenilin 1 mutant L166P were used to increase the presence of endogeneous N-cadherin C-terminal fragment 1. Under these conditions, we again found a strong acceleration of amyloid-β-induced synapse impairment, which could be compensated by over-expression of full-length N-cadherin. Intriguingly, western blot analysis of post-mortem brains from patients with Alzheimer's disease revealed an enhanced presence of N-cadherin C-terminal fragment 1. Thus, an inhibition of N-cadherin function by proteolytically generated N-cadherin C-terminal fragment 1 might play an important role in Alzheimer's disease progression by accelerating amyloid-β-triggered synapse damage.