gebhart/patrepeval huggingface dataset:
Cardiac efficiency (1995)

Journal Article Cardiac efficiency Get access C.L. Gibbs, C.L. Gibbs Department of Physiology, Monash University, Clayton, Vic. 3168, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar C.J. Barclay C.J. Barclay Department of Physiology, Monash University, Clayton, Vic. 3168, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 30, Issue 5, November 1995, Pages 627–634, https://doi.org/10.1016/S0008-6363(95)00161-1 Published: 01 November 1995 Article history Received: 01 May 1995 Accepted: 10 August 1995 Published: 01 November 1995
Applications of Ion Transport in Disordered Solids: Electrochemical Micro‐ionics (2006)

This chapter contains sections titled: Introduction Materials and Ionic Conductivity Lithium-ion-conducting Oxide Glasses in Micro-sources of Power Silver-ion-conducting Chalcogenide Glasses in Solid-state Ionic Memories and Sensors Conclusions References
Aplikasi Sosiologi Bahasa Sunda Berbasis Java 2 Micro Edition (J2ME) (2014)

Bahasa Sunda merupakan salah satu bahasa daerah yang diucapkan/ dipertuturkan di sebelah barat pulau Jawa, di daerah Tatar Sunda. Namun bahasa Sunda juga diucapkan/ dipertuturkan di Jawa Tengah , khususnya di daerah Cilacap dan Berebes. Tetapi saat ini mengenai penyebaran atau sosiologi b ahasa sunda kurang diketahui dan dipahami oleh orang sunda itu sendiri . Pemanfaatan perangkat Handphone sebagai pendamping dalam melaksanakan kegiatan sehari - hari sudah sangat lumrah bagi sebagian orang. Hal ini dikarenakan beberapa Handphone sudah memiliki fungsi dan kemampuan lebih dari sekedar fungsi dasarnya. Salah satu perangkat lunak yang dapat membuat aplikasi Handphone adalah Bahasa Pemrograman Java, khusunya Java 2 Micro Edition (J2ME) dan untuk sistem penyimpanan datanya menggunakan Record Management System (RMS). Pada laporan penelitian ini dikembangkan aplikasi sosiologi bahasa sunda , diharapkan pengguna yang menggunakan perangkat handphone dapat terbantu untuk mengetahui dan mempelajari sosiologi bahasa sunda . Kata kunci : sosiologi , bahasa sunda , J2ME , RMS
Use of an anaerobic sequencing batch reactor for parameter estimation in modelling of anaerobic digestion (2004)

The model structure in anaerobic digestion has been clarified following publication of the IWA Anaerobic Digestion Model No. 1 (ADM1). However, parameter values are not well known, and uncertainty and variability in the parameter values given is almost unknown. Additionally, platforms for identification of parameters, namely continuous-flow laboratory digesters, and batch tests suffer from disadvantages such as long run times, and difficulty in defining initial conditions, respectively. Anaerobic sequencing batch reactors (ASBRs) are sequenced into fill-react-settle-decant phases, and offer promising possibilities for estimation of parameters, as they are by nature, dynamic in behaviour, and allow repeatable behaviour to establish initial conditions, and evaluate parameters. In this study, we estimated parameters describing winery wastewater (most COD as ethanol) degradation using data from sequencing operation, and validated these parameters using unsequenced pulses of ethanol and acetate. The model used was the ADM1, with an extension for ethanol degradation. Parameter confidence spaces were found by non-linear, correlated analysis of the two main Monod parameters; maximum uptake rate (k(m)), and half saturation concentration (K(S)). These parameters could be estimated together using only the measured acetate concentration (20 points per cycle). From interpolating the single cycle acetate data to multiple cycles, we estimate that a practical "optimal" identifiability could be achieved after two cycles for the acetate parameters, and three cycles for the ethanol parameters. The parameters found performed well in the short term, and represented the pulses of acetate and ethanol (within 4 days of the winery-fed cycles) very well. The main discrepancy was poor prediction of pH dynamics, which could be due to an unidentified buffer with an overall influence the same as a weak base (possibly CaCO3). Based on this work, ASBR systems are effective for parameter estimation, especially for comparative wastewater characterisation. The main disadvantages are heavy computational requirements for multiple cycles, and difficulty in establishing the correct biomass concentration in the reactor, though the last is also a disadvantage for continuous fixed film reactors, and especially, batch tests.
OPTICAL ROTATORY DISPERSION STUDIES. XLIII.1 ABSOLUTE CONFIGURATIONAL ASSIGNMENT OF α-SUBSTITUTED CARBOXYLIC ACIDS BY ANOMALOUS ROTATORY DISPERSION OF THEIR ACYLTHIOUREA DERIVATIVES2 (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOPTICAL ROTATORY DISPERSION STUDIES. XLIII.1 ABSOLUTE CONFIGURATIONAL ASSIGNMENT OF α-SUBSTITUTED CARBOXYLIC ACIDS BY ANOMALOUS ROTATORY DISPERSION OF THEIR ACYLTHIOUREA DERIVATIVES2Carl Djerassi and Kjell UndheimCite this: J. Am. Chem. Soc. 1960, 82, 21, 5755–5756Publication Date (Print):November 1, 1960Publication History Published online1 May 2002Published inissue 1 November 1960https://pubs.acs.org/doi/10.1021/ja01506a050https://doi.org/10.1021/ja01506a050research-articleACS PublicationsRequest reuse permissionsArticle Views34Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Systemic Involvement and Uremia in a Patient with Tuberous Sclerosis (1998)

A patient with tuberous sclerosis who displayed all the manifestations of the disease had severe and refractory anemia and rapidly progressed to renal failure.
The kinetic effect of carbonic anhydrase on CaCO3 phase transformations during carbonation of Ca(OH)2 solutions (2013)

status: Published
Serosurvey for Selected Virus Infections of Wild Carnivores in Taiwan and Vietnam (1999)

Serum samples from two leopard cats (Felis bengalensis) and four Formosan gem-faced civets (Paguma larvata taivana) in Taiwan, September 1995, and nine leopard cats in Vietnam, August and December 1997, were examined for the prevalence of antibodies against feline parvovirus, feline herpesvirus type 1, feline calicivirus and feline immunodeficiency virus. All civets and nine of 11 leopard cats were shown to have antibodies against feline parvovirus (FPV), and FPV's were isolated from mononuclear cells in the peripheral blood of the six leopard cats.
THE GENDER OF THE BARBET GENUS TRICHOLAEMA VERREAUX AND VERREAUX (1987)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Inhibition of CPP32-Like Proteases Rescues Axotomized Retinal Ganglion Cells from Secondary Cell DeathIn Vivo (1998)

The majority of retinal ganglion cells (RGCs) degenerate and die after transection of the optic nerve (ON) in the adult rat. This secondary cell death can primarily be ascribed to apoptosis. Recent work strongly suggests a decisive role for a family of cysteine proteases, termed caspases, as mediators of neuronal apoptosis. In this study, we investigated whether activation of caspases contributes to delayed death of RGCs after axotomy. Intraocular application of various caspase inhibitors rescued up to 34% of RGCs that would otherwise have died 14 d after ON transection. Using a modified affinity-labeling technique, we detected a 17 kDa protease subunit upregulated after axotomy. Upregulation was prevented by caspase inhibitor treatment. The 17 kDa protein was identified as a CPP32-like protease by Western blot analysis and affinity labeling with biotinylated acetyl-Asp-Glu-Val-Asp-aldehyde, which specifically inhibits CPP32-like caspases. In vivo application of the irreversible caspase inhibitor benzyloxycarbonyl-Asp-Glu-Val-Asp-chloromethylketone revealed CPP32-like proteases to be major mediators of caspase-induced apoptosis in axotomized RGCs, because this inhibitor showed an even higher neuroprotective potential than the irreversible wide-range inhibitor benzyloxycarbonyl-Val-Ala-DL-Asp-fluoromethylketone. In summary, the data presented here provide further insight into the mechanisms of injury-induced neuronal apoptosis and could give rise to more effective therapeutic intervention strategies in CNS trauma and neurodegenerative diseases.
Modeling Barton Springs Segment of the Edwards Aquifer Using MODFLOW-DCM (2005)

The Barton Springs segment of the Edwards Aquifer is the sole source of water supply for about 45,000 people in and immediately south of Austin, Texas. For water management purposes, it is important to be able to predict the availability of groundwater in response to future development and potential droughts. The Edwards Aquifer comprises heterogeneous carbonate rock strata that have developed a well-connected network of karst conduits. This karstic geological structure makes aquifer characterization and groundwater modeling challenging. Previously, Scanlon et al. (2001) developed a two-dimensional groundwater model for the Barton Springs segment using MODFLOW. The karst conduits were not explicitly represented in the model. Instead, the study area was divided into 9 zones for which the transmissivities were obtained through calibration. We revisit Scanlon et al.'s work in this study by using MODFLOW-DCM, a MODFLOW module developed to represent flow through karstic aquifers. MODFLOW-DCM adopts a dual-conductivity approach in which the aquifer is conceptualized as being composed of two interacting flow systems, i.e., the background matrix and the karst conduits. This approach allows karst aquifers to be modeled as coupled systems, and thus allows aquifer dynamics related to karst conduit flows to be accurately simulated. Our preliminary results show improved matching of both water level measurements and spring discharges records.
Efecto del Si en la estabilidad térmica del Tic en aluminio fundido (2012)

In order to assess the effect of Si on the thermal stability of TiC in molten Al, TiC particles were incorporated into Al melts of high purity and Al-7wt.%Si. The composites were heat treated between 500°C and 1000°C and held at temperature for 48 and 6 h for the pure Al matrix and the Al-7wt.%Si alloy, respectively. The samples were characterised by scanning electron microscopy, X-ray diffraction and image analysis. The findings revealed that TiC slowly reacts in solid state, but the reactivity increases in liquid state with temperature to a maximum at 725°C and 800°C for pure Al and the Al-7wt.%Si alloy, respectively. The degradation of TiC particles in the Al melts resulted in the precipitation and growth of intermetallics into blocky shapes and little blocks of Al4C3. The latter phase was seen to coat the remaining TiC particles in heavily reacted samples. At temperatures larger than 725°C, the reaction between TiC and Al to form TiAl3 and Al4C3 decreased and between 800°C and 1000°C, dissolution of TiC in Al produces Al4C3 in decreasing levels as the temperature increases. In the Al-7wt.%Si alloy, this tendency was observed at temperatures larger than 800°C. Energy dispersive Xray analysis of the intermetallics formed in the Al-7wt.%Si alloy and X-ray patterns of the heat treated samples indicated an average composition of TiAl2.39Si0.39 with the crystalline structure of the TiAl3 phase. Comparison of the remaining TiC fractions in the Al melts reveal that Si enhances the kinetics of the dissolution of TiC and that the mechanism is different at “low” and “high” temperatures.
Cloud aided safety-based route planning (2014)

This paper proposes a novel multi-objective route planning approach within the framework of a Vehicle-to-Cloud-to-Vehicle (V2C2V) architecture. Time and road risk index (RRI) are both considered as metrics. To evaluate road segment risk, an accident database from the Highway Safety Information System (HSIS) is processed to build a comprehensive road risk assessment model. Route planning is formulated as a multi-objective network flow problem and further reduced to a Mixed Integer Programming (MIP) problem. A real-world case study, route planning through the city of Columbus, Ohio, is presented. The Vehicle-to-Cloud-to-Vehicle (V2C2V) based implementation of our safety-based route planning approach is proposed to facilitate access to real-time information and computing resources.
Editorial (2011)

Editorial Hung T KhongUniversity of South Alabama, Mitchell Cancer institute, Mobile, AL, USAWith the completion of the human genome project and the explosion of knowledge derived from genomics, proteomics, metabolomics, and other-omics, there are a vast and ever increasing number of potential druggable targets and therapeutic candidates. Each of these targets can be considered a potential biomarker that serves as a risk assessment tool and/or a biological predictor of prognosis and treatment outcome. For example, the risk of developing breast cancer in a woman who has inherited a deleterious breast cancer antigen (BRCA)1 mutation is five times that of a woman in the general population.1 When cells are damaged by chemotherapy, DNA damages are often repaired by the BRCA pathway. In cells that are deficient in BRCA functionality, an alternative pathway such as the base excision repair pathway is utilized. This pathway is dependent on poly (ADP-ribose) polymerase (PARP) being fully functional.2 Therefore, BRCA1-deficient cancer cells are exquisitely sensitive to the combinationof PARP inhibitor and chemotherapy.3,4 In this case, BRCA1 serves as a biomarker for both risk of developing breast cancer and favorable outcome to certain treatments.
Hazel Patricia Galvin (2015)

<h3>Abstract</h3> The striatum and subthalamic nucleus (STN) are considered to be the primary input nuclei of the basal ganglia. Projection neurons of both striatum and STN can extensively interact with other basal ganglia nuclei, and there is growing anatomical evidence of direct axonal connections from the STN to striatum. There remains, however, a pressing need to elucidate the organization and impact of these subthalamostriatal projections in the context of the diverse cell types constituting the striatum. To address this, we carried out monosynaptic retrograde tracing from genetically-defined populations of dorsal striatal neurons in adult male and female mice, quantifying the connectivity from STN neurons to spiny projection neurons, GABAergic interneurons, and cholinergic interneurons. In parallel, we used a combination of <i>ex vivo</i> electrophysiology and optogenetics to characterize the responses of a complementary range of dorsal striatal neuron types to activation of STN axons. Our tracing studies showed that the connectivity from STN neurons to striatal parvalbumin-expressing interneurons is significantly higher (~ four-to eight-fold) than that from STN to any of the four other striatal cell types examined. In agreement, our recording experiments showed that parvalbumin-expressing interneurons, but not the other cell types tested, commonly exhibited robust monosynaptic excitatory responses to subthalamostriatal inputs. Taken together, our data collectively demonstrate that the subthalamostriatal projection is highly selective for target cell type. We conclude that glutamatergic STN neurons are positioned to directly and powerfully influence striatal activity dynamics by virtue of their enriched innervation of GABAergic parvalbumin-expressing interneurons.
Functional thin films on surfaces (2015)

The motion of a thin viscous film of fluid on a curved surface exhibits many intricate visual phenomena, which are challenging to simulate using existing techniques. A possible alternative is to use a reduced model, involving only the temporal evolution of the mass density of the film on the surface. However, in this model, the motion is governed by a fourth-order nonlinear PDE, which involves geometric quantities such as the curvature of the underlying surface, and is therefore difficult to discretize. Inspired by a recent variational formulation for this problem on smooth surfaces, we present a corresponding model for triangle meshes. We provide a discretization for the curvature and advection operators which leads to an efficient and stable numerical scheme, requires a single sparse linear solve per time step, and exactly preserves the total volume of the fluid. We validate our method by qualitatively comparing to known results from the literature, and demonstrate various intricate effects achievable by our method, such as droplet formation, evaporation, droplets interaction and viscous fingering.
What the Orphan Drug Act Has Done Lately for Children With Rare Diseases: A 10-Year Analysis (2012)

The ODA incentives have led to increased product availability for RDs overall, with an increasing number of marketing approvals for children this past decade.
Data from <i>BRCA1</i> Mutation Analysis of 41 Human Breast Cancer Cell Lines Reveals Three New Deleterious Mutants (2023)

&lt;div&gt;Abstract&lt;p&gt;Germ line mutations of the &lt;i&gt;BRCA1&lt;/i&gt; gene confer a high risk of breast cancer and ovarian cancer to female mutation carriers. The BRCA1 protein is involved in the regulation of DNA repair. How specific tumor-associated mutations affect the molecular function of BRCA1, however, awaits further elucidation. Cell lines that harbor &lt;i&gt;BRCA1&lt;/i&gt; gene mutations are invaluable tools for such functional studies. Up to now, the HCC1937 cell line was the only human breast cancer cell line with an identified &lt;i&gt;BRCA1&lt;/i&gt; mutation. In this study, we identified three other &lt;i&gt;BRCA1&lt;/i&gt; mutants from among 41 human breast cancer cell lines by sequencing of the complete coding sequence of &lt;i&gt;BRCA1&lt;/i&gt;. Cell line MDA-MB-436 had the 5396 + 1G&gt;A mutation in the splice donor site of exon 20. Cell line SUM149PT carried the 2288delT mutation and SUM1315MO2 carried the 185delAG mutation. All three mutations were accompanied by loss of the other &lt;i&gt;BRCA1&lt;/i&gt; allele. The 185delAG and 5396 + 1G&gt;A mutations are both classified as pathogenic mutations. In contrast with wild-type cell lines, none of the &lt;i&gt;BRCA1&lt;/i&gt; mutants expressed nuclear BRCA1 proteins as detected with Ab-1 and Ab-2 anti-BRCA1 monoclonal antibodies. These three new human &lt;i&gt;BRCA1&lt;/i&gt; mutant cell lines thus seem to be representative breast cancer models that could aid in further unraveling of the function of BRCA1. (Cancer Res 2006; 66(1): 41-5)&lt;/p&gt;&lt;/div&gt;
Susceptibility of the two-dimensional electron gas: Diamagnetic spikes and gaps in the density of states (1987)

In a strong magnetic field, ${\mathrm{Br}}_{2}$-graphite intercalation compounds behave as nearly ideal two-dimensional (2D) hole gases, with nonoverlapping Landau levels, leading to large diamagnetic spikes in the susceptibility. These spikes are broadened by sample inhomogeneities, corresponding to \ensuremath{\sim}0.4% density fluctuations. As a byproduct of the analysis, some general features of the 2D susceptibility are clarified.
CSC 59940: Topics in Front End Web Application Development (syllabus) (2018)

Syllabus for the course "CSC 59940 - Front-End Web Application Development" delivered at the City College of New York in Spring 2018 by Michelle Shu and David Moon as part of the Tech-in-Residence Corps program.
Glycan Sequence‐Dependent Nod2 Activation Investigated by Using a Chemically Synthesized Bacterial Peptidoglycan Fragment Library (2013)

Nucleotide oligomerization domain-containing protein 2 (Nod2), an innate immune receptor, recognizes bacterial cell-wall peptidoglycan (PGN), the minimum ligand of which is muramyl dipeptide (MDP). Enzymatic digestion of PGN appears to be important for Nod2 recognition. PGN is degraded by muramidase or glucosamidase through a process that produces two types of glycan sequence; glycans containing GlcNAcβ(1→4)MurNAc or MurNAcβ(1→4)GlcNAc. In this report, a range of disaccharide or tetrasaccharide fragments of each sequence were chemically synthesized, and their activities in stimulating human Nod2 (hNod2) were investigated. The results reveal that hNod2 recognitions is dependent on the glycan sequence, as demonstrated by comparing the activities of glycans with the same peptide moieties. (MurNAcβ(1→4)GlcNAc)(2) -containing structures exhibited stronger activity than those containing (GlcNAcβ(1→4)MurNAc)(2) . The results suggest that differences in the enzymatic degradation process affect the host's immunomodulation process.
Mining Symbionts of a Spider‐Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones (2020)

Abstract A spider‐transmitted fungus ( Rhizopus microsporus ) that was isolated from necrotic human tissue was found to harbor endofungal bacteria ( Burkholderia sp.). Metabolic profiling of the symbionts revealed a complex of cytotoxic agents (necroximes). Their structures were characterized as oxime‐substituted benzolactone enamides with a peptidic side chain. The potently cytotoxic necroximes are also formed in symbiosis with the fungal host and could have contributed to the necrosis. Genome sequencing and computational analyses revealed a novel modular PKS/NRPS assembly line equipped with several non‐canonical domains. Based on gene‐deletion mutants, we propose a biosynthetic model for bacterial benzolactones. We identified specific traits that serve as genetic handles to find related salicylate macrolide pathways (lobatamide, oximidine, apicularen) in various other bacterial genera. Knowledge of the biosynthetic pathway enables biosynthetic engineering and genome‐mining approaches.
Development of Automatic Manipulation Device for Acupuncture (AMDA) (2014)

Needle lifting and thrusting manipulation is one of common skills in acupuncture. However, there exists artificial error in frequency and amplitude due to individual difference when performing lifting and thrusting during acupuncture. For providing stable and quantified effects and higher frequency when doing lifting and thrusting manipulation, a well controlled device is needed. The aim of this article is to report the preliminary results of the development of Auto Manipulation Device for Acupuncture (AMDA) and characterization of its functional parameters. A tissue-simulating Agar gel phantom with 4.8%, 5.2%, and 5.4% concentrations was prepared and used for characterization of the AMDA. Tests of the linearity, reliability and safety of the AMDA were implemented with conditions of different drive voltages, frequencies, and simulated tissues. Our preliminary results have demonstrated the developed AMDA its plausibility in the clinical application of acupuncture.