gebhart/patrepeval huggingface dataset:
Partial Remission after Continuous Oral Acyclovir in Darier's Disease- Two Sisters in a Family (2012)

In addition to bacterial and fungal infection, Darier’s disease may be accompanied by recurrent localized or widespread herpes simplex virus infection. The present paper presents 2 cases with >20-year histories of Darier’s disease in whom specific findings of herpes simplex virus infection were observed by quick Tzanck test with modified preservative Giemsa solution. The test was also performed to follow cytological findings after episodes of herpes simplex virus infection, revealing severe, persistent infection over erosive plaques and in keratotic papules. Continuous therapy with oral acyclovir at 400 mg twice daily was prescribed after a routine 5-day course of acyclovir or valacyclovir. After 3 months of continuous oral acyclovir therapy, itching and pain decreased and normal skin appeared without adverse effects. The quick Tzanck test was thus found to be helpful in detecting the existence of virus-infected cells and monitoring the treatment of Darier’s disease complicated by herpes simplex virus infection.
On improving the product sustainability of metallic automotive components by using the total life-cycle approach and the 6R methodology (2015)

This paper presents a novel methodology involving the use of total life-cycle approach, including the Life-cycle Assessment (LCA) method, for improving the product sustainability performance of metallic automotive components. This involves consideration of all four life-cycle stages (pre-manufacturing - PM, manufacturing - M, use - U and post-use - PU), and integration of the 6R activities (Reduce, Reuse, Recycle, Recover, Redesign and Remanufacture). Various end-of-life (EOL) product scenarios - reuse, remanufacturing, and recycling - are modeled and analyzed within the chosen SimaPro LCA software environment. By using the recently established metrics-based Product Sustainability Index (ProdSI) methodology, final aggregated product sustainability scores for different product EOL options are generated. The validated ProdSI results provide options for improving the overall product sustainability by using the new evaluation methodology. This work also shows that a closed-loop material flow, and multiple life-cycles can be achieved through the use of this new methodology.
Interaction and functional interplay between endoglin and ALK‐1, two components of the endothelial transforming growth factor‐β receptor complex (2005)

Transforming growth factor-beta (TGF-beta) signaling in endothelial cells is able to modulate angiogenesis and vascular remodeling, although the underlying molecular mechanisms remain poorly understood. Endoglin and ALK-1 are components of the TGF-beta receptor complex, predominantly expressed in endothelial cells, and mutations in either endoglin or ALK-1 genes are responsible for the vascular dysplasia known as hereditary hemorrhagic telangiectasia. Here we find that the extracellular and cytoplasmic domains of the auxiliary TGF-beta receptor endoglin interact with ALK-1 (a type I TGF-beta receptor). In addition, endoglin potentiates TGF-beta/ALK1 signaling, with the extracellular domain of endoglin contributing to this functional cooperation between endoglin and ALK-1. By contrast, endoglin appears to interfere with TGF-beta/ALK-5 signaling. These results suggest that the functional association of endoglin with ALK-1 is critical for the endothelial responses to TGF-beta.
A new consensus error grid to evaluate the clinical significance of inaccuracies in the measurement of blood glucose. (2000)

The consensus EGs furnish a new tool for evaluating errors in the measurement of BG for patients with type 1 and type 2 diabetes.
Preparation of Ti-V-Cr Hydrogen Absorption Alloy Powder (2004)

A new method was developed to synthesize the hydrogen storage alloy powders directly from the oxide mixtures. Calcium co-reduction and the molten CaCl2 was applied to reduce the oxides and to form the target alloy simultaneously. As the fundamental confirmation, the binary Ti-V solid solution and the intermetallic compound TiCr2 were prepared. Their oxygen content was controlled below 0.5mass% and the compositional variation of metallic elements was within 5mol% from the desired compositions. These alloy powders could absorb hydrogen after the normal activation treatment.
Optimal decoupling for improved multivariable controller design, applied on an automotive vibration test rig (2004)

Within the framework of tracking controller design for an automotive vibration test rig, a new control strategy is developed which is applicable to square multiple-input-multiple-output systems (MIMO-systems) with a certain degree of symmetry. Classical MIMO-controller design is a three step procedure: response measurement, MIMO-identification and MIMO-controller design. The latter two steps are often very cumbersome due to the multivariable character of the problem. In. this paper, a new procedure is proposed which replaces the second step with: (1) almost decoupling of the MIMO-system into multiple single-input-single-output systems (SISO-systems) by transformations of the inputs and the outputs; and (2) SISO-identifications of the decoupled systems. Thereby simplifying the control-design step to multiple SISO-controller designs. This paper also discusses the successful application of this new procedure on an industrial automotive vibration test rig.
The effects of diallyl sulfide upon Porphyromonas gingivalis lipopolysaccharide stimulated proinflammatory cytokine expressions and nuclear factor‐kappa B activation in human gingival fibroblasts (2014)

DAS diminished P. gingivalis lipopolysaccharide-stimulated cytokine expression and NF-κB activation in HGFs; we therefore suggest DAS may be beneficial on periodontal inflammation.
Parallel genehunter: implementation of a linkage analysis package for distributed-memory architectures (2002)

We present a parallel algorithm for performing multipoint linkage analysis of genetic marker data on large family pedigrees. The algorithm effectively distributes both the computation and memory requirements of the analysis. We discuss an implementation of the algorithm in the Genehunter linkage analysis package (version 2.1), enabling Genehunter to be run on distributed memory platforms for the first time. Our preliminary benchmarks indicate reasonable scalability of the algorithm for even small fixed-size problems, with parallel efficiencies of 75% or more on up to a few dozen processors.
Anode plasma formation in a diode with carbon fiber cathode (2008)

Summary form only. We report results on the generation of a high-current electron beam in a diode with different type carbon fiber cathodes with and without Csl coating at a pressure of ~8x10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-5</sup> Torr, under an accelerating pulse with amplitude of ~ 300 kV and ~300 ns duration. Different diagnostics which include collimated Faraday cup array, time-resolved multi pin-hole camera, X-ray imaging of the electron beam, fast framing 4Quick05A camera for visible imaging of the cathode plasma light emission and visible time and space resolved spectroscopy were used to study parameters of the generated electron beam and cathode plasma.
Improved Drying in a Pulsation-Assisted Fluidized Bed (2008)

Gas flow pulsation was employed to improve the drying of porous pharmaceutical granules in a cylindrical fluidized bed. In our approach, a fraction of the total flow was oscillating intermittently and periodically, typically at 3 Hz during 2 min and remaining constant during the other 2 min of each 4 min cycle. It was found that such pulsation-assisted fluidization not only shortened the total drying time but also enhanced homogeneity. A transition in fluidization behavior, reflected by a distinct transition in the bed dominant frequencies, was observed.
Technical Aspects of Prone Dependent-Breast Scintimammography (1994)

Objective: We describe the technical aspects of scintimammography for detecting breast cancer in patients with positive mammography or positive clinical findings. Methods: Prone dependent-breast scintimammography was performed on 390 patients evaluated for the presence of breast cancer. Planar images were acquired beginning 5 min following intravenous injection of 20 mCi of 99mTc-sestamibi. Complementary imaging by SPECT was performed in 29 selected cases. Results: The prone dependent-breast position was well tolerated by patients, and resulted in high-quality images with easily identifiable anatomic landmarks. The sensitivity of scintimammography was 96% and specificity was 85% in 62 lesions with pathologic correlation. Interobserver agreement was 96% and intraobserver diagnostic variability was Conclusion: The high ratio of lesion-to-background sestamibi activity and excellent separation of breast tissue from the heart and liver and anterior chest wall provides a reliable noninvasive means of breast cancer detection.
Glucosamine. A nutraceutical in osteoarthritis. (2002)

Recent research suggests that it may not only provide symptomatic pain relief, but may have a role in chondroprotection.
PIC/MCC simulation for a ns-pulsed glow discharge in nitrogen at sub-atmospheric pressure and analysis of its quasi-steady state physics (2023)

Abstract The present study investigates the physics of a nanosecond-pulsed microplasma operated at a pressure of 200 mbar with the help of a particle-in-cell simulation with Monte Carlo treatment of collision (PIC/MCC) and (semi-)analytical models. The discharge is ignited in a 1 mm gap between two parallel molybdenum electrodes by applying a voltage in the kV-range for several tens to hundreds of nanoseconds. A PIC/MCC simulation code is developed in order to describe the experiment performed under identical conditions. The simulation includes the external electrical circuit to perform ab-initio calculations of the complete experimental setup. Notable features of the PIC/MCC are (i) the adjustment of super-particle weights to reduce the computational load during drastic changes of the plasma density, which reaches values up to a few <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:msup> <mml:mn>10</mml:mn> <mml:mrow> <mml:mn>19</mml:mn> </mml:mrow> </mml:msup> <mml:msup> <mml:mrow> <mml:mi mathvariant="normal">m</mml:mi> </mml:mrow> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>3</mml:mn> </mml:mrow> </mml:msup> </mml:math> , and (ii) the inclusion of dissociative recombination of the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:msup> <mml:mrow> <mml:msub> <mml:mi mathvariant="normal">N</mml:mi> <mml:mn>4</mml:mn> </mml:msub> </mml:mrow> <mml:mo>+</mml:mo> </mml:msup> </mml:math> ions, which is the key loss process for the charge carriers in the plasma bulk regions. The current and voltage waveforms obtained from the simulation are compared to the experimentally measured ones and good agreement is found. After ignition, the discharge establishes a quasi-steady state exhibiting spatial features similar to a conventional DC glow discharge. Using the PIC/MCC results, reasonable approximations are identified, which allow the development of various analytical fluid models for the individual plasma regions. These models are able to reproduce the key features of the discharge in agreement with the PIC/MCC results. The simplified models for the different discharge regions can be combined to describe the global behaviour of the discharge and—in a next step—might be used to develop computationally efficient global chemistry models that account for the different power dissipation mechanisms along the discharge gap.
Detailed structural analysis of asparagine‐linked oligosaccharides of the nicotinic acetylcholine receptor from Torpedo californica (1992)

The structures of the major oligosaccharide moieties of the nicotinic acetylcholine receptor (AcChoR) protein from Torpedo californica have been reported [Nomoto, H., Takahashi, N., Nagaki, Y., Endo, S., Arata, Y. and Hayashi, K. (1986) Eur. J. Biochem. 157, 233-242] to be high-mannose types. Here we report detailed analyses of the structures of the remaining oligosaccharides in this receptor. The sialylated oligosaccharides released by glycopeptidase (almond) digestion were separated according to the number of sialic acid residues using high-performance anion-exchange chromatography with pulsed amperometric detection. After removal of sialic acid from each fraction, the resulting neutral oligosaccharides were separately pyridylaminated and were analyzed by a combination of sequential exoglycosidase digestion and HPLC, then identified on a two-dimensional sugar map. The structures of two desialylated pyridylamino-oligosaccharides were further analyzed by high-resolution proton NMR. Each oligosaccharide was composed of species containing varying numbers of sialic acids. The desialylated complex-type oligosaccharides of AcChoR consisted of ten, eight and one different biantennary, triantennary and tetraantennary oligosaccharide, respectively. The biantennary oligosaccharides were divided into two groups; oligosaccharides with fucose at the proximal N-acetylglucosamine (six varieties) and oligosaccharides without fucose (four varieties). Each group consisted of species differing in the number of terminal galactose residues. The major component of the biantennary oligosaccharides had two galactose residues at the non-reducing termini. The terminal alpha-galactose residue(s) linked to C3 of beta-galactose were found in the fucose-containing biantennary oligosaccharides (two varieties). The triantennary oligosaccharides were also divided into two groups; oligosaccharides with (four varieties) and without (four varieties) besecting N-acetylglucosamine. These groups were composed of species differing in the number of terminal galactose residues. The major component of the triantennary oligosaccharides was fully galactosylated with three galactose residues. An unusual group, Gal beta 1-3GlcNAc, was present in low levels in the triantennary oligosaccharides. In contrast, the tetraantennary oligosaccharide was composed of only one species, which is fully galactosylated with four galactose residues.
Data Augmentation to Stabilize Image Caption Generation Models in Deep Learning (2019)

Automatic image caption generation is a challenging AI problem since it requires utilization of several techniques from different computer science domains such as computer vision and natural language processing. Deep learning techniques have demonstrated outstanding results in many different applications. However, data augmentation in deep learning, which replicates the amount and the variety of training data available for learning models without the burden of collecting new data, is a promising field in machine learning. Generating textual description for a given image is a challenging task for computers. Nowadays, deep learning performs a significant role in the manipulation of visual data with the help of Convolutional Neural Networks (CNN). In this study, CNNs are employed to train prediction models which will help in automatic image caption generation. The proposed method utilizes the concept of data augmentation to overcome the fuzziness of well-known image caption generation models. Flickr8k dataset is used in the experimental work of this study and the BLEU score is applied to evaluate the reliability of the proposed method. The results clearly show the stability of the outcomes generated through the proposed method when compared to others.
Biological detection of specific mRNA molecules by microinjection. (1979)

We have used direct microinjection of messenger RNA into individual mouse and human cells to assay for specific translation products. We have been able to detect the synthesis of human fibroblast interferon, thymidine, kinase, hypoxanthine phosphoribosyltransferase, adenine phosphoribosyltransferase, and propionyl-CoA carboxylase in response to injected mRNA. Using the interferon system as a model, we have quantitated interferon synthesis and followed partial purification of interferon mRNA sequences on sucrose density gradients. The methods we have utilized should be applicable to other systems in which sensitive assays exist for gene products and should provide a screening procedure for isolating specific mRNA sequences.
Molecular Genetics of Extranodal Marginal Zone (MALT-Type) B-Cell Lymphoma (1999)

Mucosa-associated lymphoid tissue lymphoma is now classified as extranodal marginal zone B-cell lymphoma. We reviewed the current literature on the biological and genetic mechanisms that lead to the development and progression of this unusual lymphoma. Particular attention was given to the clinical and biological significance of the immunoglobulin genes rearrangement, that has been proposed and widely used both diagnostically and as a tool to monitor the response to antibiotic treatment.
Arranjos produtivos locais e suas influências no desenvolvimento da economia regional (2008)

Resumen pt: Neste artigo, demonstrase o papel dos clusters no desenvolvimento economico regional mediante acooperacao dos atores na cadeia produtiva. Paraisso, utili...
Executable assertions for detecting data errors in embedded control systems (2002)

In order to be able to tolerate the effects of faults, we must first detect the symptoms of faults, i.e. the errors. This paper evaluates the error detection properties of an error detection scheme based on the concept of executable assertions aiming to detect data errors in internal signals. The mechanisms are evaluated using error injection experiments in an embedded control system. The results show that using the mechanisms allows one to obtain a fairly high detection probability for errors in the areas monitored by the mechanisms. The overall detection probability for errors injected to the monitored signals was 74%, and if only errors causing failure are taken into account we have a detection probability of over 99%. When subjecting the target system to random error injections in the memory areas of the application, i.e., not only the monitored signals, the detection probability for errors that cause failure was 81%.
Spectral domain optical coherence tomography with sub-micrometer sensitivity for measurement of central corneal thickness (2019)

We demonstrated a method for measurement of central corneal thickness (CCT) with a sub-micrometer sensitivity using a spectral domain optical coherence tomography system without needing a super broad bandwidth light source. By combining the frequency and phase components of Fourier transform, the method is capable of measurement of a large dynamic range with a high sensitivity. Absolute phases are retrieved by comparing the correlations between the detected and simulated interference fringes. The phase unwrapping ability of the present method was quantitatively tested by measuring the displacement of a piezo linear stage. The human CCTs of six volunteers were measured to verify its clinical application. It provides a potential tool for clinical diagnosis and research applications in ophthalmology.
Oxidation by DNA Charge Transport Damages Conserved Sequence Block II, a Regulatory Element in Mitochondrial DNA (2007)

Sites of oxidative damage in mitochondrial DNA have been identified on the basis of DNA-mediated charge transport. Our goal is to understand which sites in mitochondrial DNA are prone to oxidation at long range and whether such oxidative damage correlates with cancerous transformation. Here we show that a primer extension reaction can be used to monitor directly oxidative damage to authentic mitochondrial DNA through photoreactions with a rhodium intercalator. The complex [Rh(phi)2bpy]Cl3 (phi = 9,10-phenanthrenequinone diimine) binds to DNA without sequence specificity and, upon photoactivation, either promotes strand breaks directly at the binding site or promotes one-electron oxidative damage; comparing the sites of base oxidation to direct strand breaks reveals the oxidative damage that arises from a distance through DNA-mediated charge transport. Significantly, base oxidation by charge transport overlaps with known mutational hot spots associated with cancers at nucleotides surrounding positions 263 and 303; the latter is known as conserved sequence block II and is vital to DNA replication. Since DNA base oxidation at conserved sequence block II should weaken the ability of damaged mitochondrial genomes to be replicated, DNA-mediated charge transport may provide a protection mechanism for excluding damaged DNA.
The BioScope corpus: biomedical texts annotated for uncertainty, negation and their scopes (2008)

Statistics are reported on corpus size, ambiguity levels and the consistency of annotations. The corpus is accessible for academic purposes and is free of charge. Apart from the intended goal of serving as a common resource for the training, testing and comparing of biomedical Natural Language Processing systems, the corpus is also a good resource for the linguistic analysis of scientific and clinical texts.
Heat production in microwave-irradiated thermocouples (1986)

It has been known for some time that the irradiation of metallic thermometers by microwaves during clinical hyperthermia can lead to artifactual readings. We describe here a series of measurements in which this effect has been quantitatively studied. In particular, the data yield values for the conversion coefficient describing the rate of heat production per unit length of a thermocouple array per watt applied power which can be compared with the rate of heat production in the same volume of tissue. The degree of artifact in the temperature recording depends on the thermal resistance of the protective materials surrounding the array, and this thermal resistance has also been determined. It has been shown that measures taken to reduce the temperature artifact do not compromise the response time of the probe.
ANZOP ACOFT Melb 2019 true time delay (2020)

A microwave photonic true time delay line based on an integrated Kerr comb source with 49 GHz free spectral range was proposed and demonstrated. We theoretically analyze the performance of a phased array antenna and show that this large channel count results in a highangular resolution and wide beam-steering tunable range.
Computer Aided Technique for Finger Print Image Enhancement and Minutiae Extraction (2013)

Biometrics is the science and technology of measuring and analyzing biological data of human body, extracting a feature set from the acquired data, and comparing this set against to the template set in the database. Biometric techniques are gaining importance for personal authentication and identification as compared to the traditional authentication methods. User verification systems that use a single biometric indicator often have to contend with noisy sensor data, restricted degrees of freedom, and unacceptable error rates. To represent the large amount of data in the biometric images an efficient feature extraction method is needed. This paper presents the feature extraction of fingerprint image processing stages such as image Preprocessing, Converting the image in to gray scale, Image Enhancement can be performed with the help of Discrete Fourier transformation, image Binarization, image segmentation, image thinning, Minutiae Extraction after Minutiae Extraction again segmentation technique is used .In finger print images there are foreground regions and background regions where foreground region show the ridges and valleys while the background regions are to be left out. .The foreground regions have high value while the background regions have low values. Segmentation separates the foreground region from the background image for the reliable extraction of minutiae. The feature extraction is the first step used for matching used in biometric recognition. After feature extraction the next step is preprocessing of Minutiae. The extracted feature is called as templates, which is used in matching.