gebhart/patrepeval huggingface dataset:
Constitutive activation of LIL-Stat in adult T-cell leukemia cells (2000)

The activation status of a recently identified STAT (signal transducers and activators of transcription) factor, LIL-Stat (lipopolysaccharide [LPS]/IL-1–inducible Stat) in adult T-cell leukemia (ATL) cells was investigated by electrophoretic mobility shift assays using nuclear extracts of leukemic cells from 7 patients with ATL and a GAS (gamma interferon activation site)-like element termed LILRE (LPS/IL-1–responsive element), which is found in the human prointerleukin 1β (IL1B) gene. Spontaneous DNA binding of LIL-Stat was observed in all ATL cells examined. However, in normal human peripheral lymphocytes, DNA binding of LIL-Stat was detected only after stimulation with IL-1. These results demonstrated that LIL-Stat is constitutively activated in ATL cells. Furthermore, our transient transfection studies using LILRE chloramphenicol acetyltransferase (CAT) reporters argue that LIL-Stat in ATL cells functions as a transcriptional activator through binding to the LILRE in theIL1B gene.
Understanding pyrroline‐5‐carboxylate synthetase deficiency: clinical, molecular, functional, and expression studies, structure‐based analysis, and novel therapy with arginine (2011)

Δ(1)-Pyrroline-5-carboxylate synthetase (P5CS) catalyzes the first two steps of ornithine/proline biosynthesis. P5CS deficiency has been reported in three families, with patients presenting with cutis/joint laxity, cataracts, and neurodevelopmental delay. Only one family exhibited metabolic changes consistent with P5CS deficiency (low proline/ornithine/citrulline/arginine; fasting hyperammonemia). Here we report a new P5CS-deficient patient presenting the complete clinical/metabolic phenotype and carrying p.G93R and p.T299I substitutions in the γ-glutamyl kinase (γGK) component of P5CS. The effects of these substitutions are (1) tested in mutagenesis/functional studies with E.coli γGK, (2) rationalized by structural modelling, and (3) reflected in decreased P5CS protein in patient fibroblasts (shown by immunofluorescence). Using optical/electron microscopy on skin biopsy, we show collagen/elastin fiber alterations that may contribute to connective tissue laxity and are compatible with our angio-MRI finding of kinky brain vessels in the patient. MR spectroscopy revealed decreased brain creatine, which normalized after sustained arginine supplementation, with improvement of neurodevelopmental and metabolic parameters, suggesting a pathogenic role of brain creatine decrease and the value of arginine therapy. Morphological and functional studies of fibroblast mitochondria show that P5CS deficiency is not associated with the mitochondrial alterations observed in Δ(1)-pyrroline-5-carboxylate reductase deficiency (another proline biosynthesis defect presenting cutis laxa and neurological alterations).
Magnetization Reversal by Field and Current Pulses in Elliptic CoFeB/MgO Tunnel Junctions With Perpendicular Easy Axis (2016)

We fabricate elliptic CoFeB/MgO magnetic tunnel junctions (MTJs) with perpendicular magnetic easy axis with different in-plane aspect ratios (ARs) from 1 to 4 with the same area as that of a 100 nm diameter circular MTJ. We evaluate their thermal stability factors from magnetization switching probability measurements by using either applied magnetic field pulses or current pulses. The thermal stability factors determined from field-pulse measurement appear to decrease with increasing AR, whereas those from current-pulse measurement depend much less on AR. These results imply that the different drives induce switching through different magnetization reversal modes.
Clinical and Laboratory Biomarkers in the Management of Pancreatic Adenocarcinoma (2012)

Despite improvements in the health service and the available treatment means, the outcome of the majority of patients with advanced pancreatic adenocarcinoma, even in the Western world, is disappointing. This fact necessitates invention and development of clinical and laboratory biomarkers that help us detect early enough those patients who have the worst prognosis, and who may benefit or not from our treatments and individualize thus our management accordingly. In the 2012 American Society of Clinical Oncology (ASCO) Annual Meeting, four interesting scientific works on biomarkers in pancreatic cancer were presented. Two of them presented new clinical data such as the correlation of hand and foot skin reaction with the prognosis of patients treated with capecitabine based treatment (Abstract #4023), and the independent association of early presentation of venous thromboembolic events with poor survival (Abstract #4037). The other two significant abstracts focused on new potential predictive laboratory biomarkers, such as the association of the baseline levels of serum albumin to benefit from bevacizumab enriched treatment (Abstract #4039) and the likely correlation of high insulin growth factor 1 (IGF-1) tissue expression to better prognosis in patients treated with the IGF-1 receptor monoclonal antibody (mAb) MK-0646 (Abstract #4054).
Supplementary Material from Molecular and Immunologic Signatures are Related to Clinical Benefit from Treatment with Vocimagene Amiretrorepvec (Toca 511) and 5-Fluorocytosine (Toca FC) in Patients with Glioma (2023)

&lt;p&gt;Supplementary Figures S1 to S9 and Supplementary Table S1.&lt;/p&gt;
Development and Characterization of Polyurethane and Acrylonitrile Butadiene Styrene and their Compatibilized Blends (2017)

Abstract Novel blends of polyurethane and acrylonitrile butadiene styrene, in both forms, compatibilized and uncompatibilized, were developed by melt reactive extrusion technique in a twin-screw extruder. This technique involved acrylonitrile butadiene styrene grafted maleic anhydride (ABS-g-MAH) as the compatibilizer. The objective of this study was to enhance the rigidity characteristics of polyurethane by melt blending acrylonitrile butadiene styrene into polyurethane using a compatibilizer. The blends were analyzed using different techniques to confirm the occurrence of compatibilization reaction between the parent polymers and the compatibilizer. It is observed that addition of the compatibilizer has improved the mechanical properties of the resultant blends.
XPS core-level shifts and XANES studies of Cu-Pt and Co-Pt alloys (2000)

The K and L2,3 absorption edges and core-level binding-energy shifts for pure Co, Cu and Pt and Co–Pt and Cu–Pt alloys are measured to investigate changes in electronic structures of these alloys. Enhancements and depletion of the white lines in the alloys as compared to pure elements were correlated with changes in the unoccupied density of states upon alloying. We find that the Pt atoms lost d3/2 electrons and gained d5/2 electrons when alloyed with Cu and Co. However, the total 5d occupancy changes of the Pt were very little in Cu–Pt alloys, and this is consistent with the small shifts of Pt 4f core-level binding energy. From the quantitative analysis of Cu and Co K-edge absorption spectra, it is found that Cu and Co have significant valence occupation changes due to dehybridization of p–d states. From these results, we suggest that the core-level shifts are affected mainly by the d-valence electron changes in these alloys. Copyright © 2000 John Wiley & Sons, Ltd.
3,4-Alkylenedioxy ring formation via double Mitsunobu reactions: an efficient route for the synthesis of 3,4-ethylenedioxythiophene (EDOT) and 3,4-propylenedioxythiophene (ProDOT) derivatives as monomers for electron-rich conducting polymers (2002)

3,4-Alkylenedioxy ring functionalized thiophenes (XDOT’s) have been synthesized by double Mitsunobu reactions to yield precursors to monomers for conjugated and electrically conducting polymers, including the commercially important 3,4-ethylenedioxythiophene (EDOT).
Rapid eye movement (REM)-sleep during and after continuous infusion of the oxazoline derivate S3341: a comparison with clonidine. (1984)

The frequency and duration of rapid eye movement (REM)-sleep episodes were examined in normotensive rats during and after cessation of continuous infusion of either clonidine (10 micrograms/kg/h) or the oxazoline derivative S3341 (50 micrograms/kg/h) for 10 days. Both compounds abolished REM-sleep during the infusion. On cessation of the clonidine infusion there was a rebound increase in the frequency and duration of REM-sleep episodes. These episodes were associated with markedly exaggerated blood pressure fluctuations. On cessation of the S3341 infusion, the frequency and duration of REM-sleep episodes returned to control levels. Blood pressure responses were not different from controls. These post-infusion differences may be related to the greater degree of selectivity of S3341 for the alpha 2-adrenoceptor rather than the alpha 1-adrenoceptor subtype.
Resuscitative endovascular balloon occlusion of the aorta during non-ST elevation myocardial infarction: A case report (2018)

Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a hemorrhage control technique that is increasingly being adopted for the management of noncompressible bleeding. In addition to limiting hemorrhage, REBOA increases blood flow to the heart, lungs, and brain. A small number of case reports and animal studies describe the use of REBOA to increase coronary perfusion during cardiopulmonary resuscitation. We report a case in which REBOA may have reversed ST-segment abnormalities during a Type II non-ST elevation myocardial infarction (NSTEMI) in a patient with previous trauma. We describe the presentation, course, and decision making that contributed to the use of REBOA in this case. Additionally, we will present a review of the literature on the effects of REBOA on coronary perfusion.
Surface wave tomography from microseisms in Southern California (2005)

Since it has already been demonstrated that point‐to‐point seismic propagation Green Functions can be extracted from seismic noise, it should be possible to image Earth structure using the ambient noise field. Seismic noise data from 148 broadband seismic stations in Southern California were used to extract the surface wave arrival‐times between all station pairs in the network. The seismic data were then used in a simple, but densely sampled tomographic procedure to estimate the surface wave velocity structure within the frequency range of 0.1–0.2 Hz for a region in Southern California. The result compares favorably with previous estimates obtained using more conventional and elaborate inversion procedures. This demonstrates that coherent noise field between station pairs can be used for seismic imaging purposes.
Blutzuckerselbstkontrolle bei nicht mit Insulin behandelten Typ-2-Diabetikern verbessert das Wohlbefinden, vermindert die Depressivität und reduziert das Ausmaß diabetesspezifischer Belastungen: Ergebnisse der STeP Studie (2011)

Fragestellung: Über den Zusammenhang zwischen der Blutzuckerselbstkontrolle (BZSK) bei nicht mit Insulin behandelten Typ-2-Diabetikern und patientenrelevanten Variablen wie Wohlbefinden, Depressivität oder Ausmaß diabetesspezifischer Belastungen der Patienten gibt es bisher nur wenige aussagekräftige Studien. Diese erbrachten zudem differierende Ergebnisse. In der prospektiven, cluster-randomisierten multizentrischen klinischen Studie STeP (Structured Testing Protocol) wurde diese Fragestellung in einem 1-Jahr-Follow-up untersucht.
Efficient Estimation of Linear Parameters from Correlated Node Measurements over Networks (2014)

We investigate the performance of distributed estimation of static parameters in networks whose nodes make correlated measurements. The measurement models are linear with node specific time-varying observation matrices. The nodes cooperate with their neighbors by exchanging information that allow for approximation of the sufficient statistics in the estimation. We prove that the proposed estimation method is efficient. Specifically, we show that the performances of the distributed estimator and the centralized one are asymptotically the same, i.e., the limit of the ratio of their variances is 1.
The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function (2013)

GPRC6A (GPCR, class C, group 6, subtype A) is a class C GPCR that has been cloned from human, mouse and rat. Several groups have shown that the receptor is activated by a range of basic and small aliphatic L-α-amino acids of which L-arginine, L-lysine and L-ornithine are the most potent compounds with EC50 values in the mid-micromolar range. In addition, several groups have shown that the receptor is either directly activated or positively modulated by divalent cations such as Ca(2+) albeit in concentrations above 5 mM, which is above the physiological concentration in most tissues. More recently, the peptide osteocalcin and the steroid testosterone have also been suggested to be endogenous GPRC6A agonists. The receptor is widely expressed in all three species which, along with the omnipresence of the amino acids and divalent cation ligands, suggest that the receptor could be involved in a broad range of physiological functions. So far, this has mainly been addressed by analyses of genetically modified mice where the GPRC6A receptor has been ablated. Although there has been some discrepancies among results reported from different groups, there is increasing evidence that the receptor is involved in regulation of inflammation, metabolism and endocrine functions. GPRC6A could thus be an interesting target for new drugs in these therapeutic areas.
T-Cell Adoptive Immunotherapy (2004)

Adoptive transfer originally referred to the ability to confer protective immunity on a naïve host via infusion of T lymphocytes from an immune donor. This term now also encompasses a strategy of cancer therapy in which autologous T cells are acquired from a tumor-bearing host then activated and numerically expanded ex vivo prior to reinfusion. It has been nearly 50 yr since Mitchison’ s initial observation that adoptive transfer of “cellular elements” from immune hosts could accelerate rejection of tumor transplants in naïve recipients (1). Since then, considerable progress has been made in defining T lymphocytes as the central component of the antitumor response with the ability to directly kill tumor cells and orchestrate other host effector mechanisms. With the importance of T cells firmly established, tumor-reactive T-cell clones have been successfully used as probes to identify tumor-associated antigens that are currently being investigated as vaccine reagents.
Identifying Wrong Links between Datasets by Multi-dimensional Outlier Detection (2014)

Abstract. Links between datasets are an essential ingredient of Linked Open Data. Since the manual creation of links is expensive at large-scale, link sets are often created using heuristics, which may lead to errors. In this paper, we propose an unsupervised approach for finding erroneous links. We represent each link as a feature vector in a higher dimen-sional vector space, and find wrong links by means of different multi-dimensional outlier detection methods. We show how the approach can be implemented in the RapidMiner platform using only off-the-shelf com-ponents, and present a first evaluation with real-world datasets from the Linked Open Data cloud showing promising results, with an F-measure of up to 0.54, and an area under the ROC curve of up to 0.86.
Cholinergic Vasodilatation of Coronary Resistance Vessels in Dogs, Baboons and Goats (1990)

Intracoronary infusion of acetylcholine produces a prompt increase in coronary blood flow in dogs, but a paradoxical decrease has been reported in baboons and cattle. The action of acetylcholine was reexamined in anesthetized dogs, baboons and goats, with the coronary circulation pump perfused at constant pressure and the heart rate held constant with electrical pacing. Intracoronary infusions of low doses of acetylcholine produced coronary vasodilatation and an increase in coronary venous oxygen tension without a change in cardiac contractility (dP/dt) or myocardial oxygen consumption in all three species. High doses of acetylcholine produced coronary vasodilatation only in dogs, but resulted in a decrease in cardiac contractility and myocardial oxygen consumption accompanied by a decrease in coronary flow in baboons and goats. It is concluded that low doses of acetylcholine produce coronary vasodilatation in all three species, and that the decrease in coronary blood flow observed in baboons and goats at high doses is probably due to local metabolic vasoconstriction secondary to the negative inotropic effects of acetylcholine.
In Situ Crosslinking of Highly Porous Chitosan Scaffolds for Bone Regeneration: Production Parameters and In Vitro Characterization (2017)

Various methods of chitosan scaffold production are reported in the literature so far. Here, in situ crosslinking with glutaraldehyde is reported for the first time. It combines pore formation and chitosan crosslinking in a single step. This combination allows incorporation of fragile molecules into 3D porous chitosan scaffolds produced by simple and gentle lyophilization. In this study, parameters of in situ crosslinking of porous chitosan scaffold formation as well as their effect on degradation and bioactivity of the scaffolds are examined. The scaffolds are characterized in the context of their prospective application as bone substitute material. The addition of calcium phosphate phases (hydroxyapatite, brushite) to the macroporous chitosan scaffolds allows manipulation of the bioactivity that is investigated by incubation in simulated body fluid (SBF). The bioactivity is significantly influenced by the modus of changing the fluid (static, daily‐, and twice‐a‐week change). Scaffolds are morphologically characterized by means of scanning electron microscopy, and the mechanical stability is tested after incubation in SBF and phosphate‐buffered saline.
Equipment and Instrumentation to Develop Nonlinear Optical Materials for Photonic and Laser Technologies. (1994)

Abstract : Acquiring the necessary infrastructure for conducting research in the area of photonic and laser technologies, the major objective of this proposal, has been accomplished through the acquisition of a number of key instruments. Our newly established Laser Assisted Experiments (LAE) facility is now equipped to conduct experiments related to all three major nonlinear optical (NLO) phenomena of polymers: (1) second order NLO effect, applicable to second harmonic generation and linear electrooptic effect (2) third order NLO effect, applicable to integrated optics such as optical switching and optical data processing and (3) photorefractive effect, applicable to real time holography and optical phase conjugation.
Mitigating the Impact of Noise on Nonlinear Frequency Division Multiplexing (2020)

In the past years, nonlinear frequency division multiplexing (NFDM) has been investigated as a potentially revolutionary technique for nonlinear optical fiber communication. However, while NFDM is able to exploit the Kerr nonlinearity, its performance lags behind that of conventional systems. In this work, we first highlight that current implementations of NFDM are strongly suboptimal, and, consequently, oversensitive to noise: the modulation does not ensure a large minimum distance between waveforms, while the detection is not tailored to the statistics of noise. Next, we discuss improved detections strategies and modulation techniques, proposing some effective approaches able to improve NFDM. Different flavors of NFDM are compared through simulations, showing that (i) the NFDM performance can be significantly improved by employing more effective detection strategies, with a 5.6 dB gain in Q-factor obtained with the best strategy compared to the standard strategy; (ii) an additional gain of 2.7 dB is obtained by means of a simple power-tilt modulation strategy, bringing the total gain with respect to standard NFDM to 8.3 dB; and (iii) under some parameters range (rate efficiency η≤30%), the combination of improved modulation and detection allows NFDM to outperform conventional systems using electronic dispersion compensation.
2008: The Year of Revitalization (2008)

Look for innovations in products and services that focus on career and professional development
Excitation of Plasma Waves Propagating Transverse to the Uniform External Magnetic Field (1965)

Using the perturbation method, the motion of an electron in a perturbed longitudinal plasma wave is studied. The wavelength of the wave is assumed to be small compared with the electron Larmor radius. The criterion for excitation and damping of the plasma wave is then obtained. Frequencies of waves which are excited are found to be nearly equal to integral mltiples of the electron cyclotron frequency. The result is applied to the explanation of the phenomenon of high cyclotron harmonics radiation.
Sofa dermatitis (2010)

Furniture components can cause contact allergies. In the last years several cases of eczema after sofa contact have been reported. Typically the skin lesions develop on the back, the buttocks, the dorsal aspects of the thighs and arms and are often very resistant to topical corticoid therapy. Dimethylfumarate (DMF) is postulated to be the causative agent for this Type IV hypersensitivity reaction. DMF is an antimicrobial substance, which is used in asian upholstered furniture industry amongst others. We report the case of a 65-year old patient with generalised severely itching maculopapular, partly eczematous skin lesions on the buttocks, back, abdomen and arms. The resistance to therapy, several relapses after discharge from hospital as well as the detailed history lead us to the tentative diagnosis. The sofa dermatitis was proven by positive patch testing with furniture material and dimethylfumarate.
Cell Identifier Assignment in Two-Tier Femtocell Networks (2013)

Small cells, mainly femtocells, are believed to be a way how to deal with mobile data traffic growth in the upcoming years. To enable easy and massive femtocell deployments, a distributed method of Physical Cell Identifier (PCI) assignment should be implemented in Femtocell Access Points among other self-organizing functionalities. In this paper, we propose such a distributed algorithm enabling correct PCI assignment in a collision-free manner and resolving all confusion events based on neighbouring cells' PCIs. The proposed algorithm is compared with the classical random algorithm by taking into account various femtocell densities, PCI ranges and sizes of neighbourhood area. Based on obtained results, the proposed algorithm leads to fewer confusion events and lower signalling network overhead even in dense femtocell environments such as office buildings or homes in city centres.
Determining morphological structures’ stiffness values of tumor tissue by optical coherence elastography (2020)

As was shown earlier in the animal experiments, compression optical coherence elastography (OCE) is a highly sensitive method for studying the morphological features of biological tissues. An attempt was made to study the possibilities of the OCE method for identifying and differentiating from each other various morphological structures in human tissues. Postoperative samples of human breast cancer and human colon cancer were studied. Histological examination identified areas of morphological structures - (I) adipose tissue, (II) stroma and (III) tumor tissue in breast cancer samples; and areas of (I) mucous membrane and (II) tumor tissue in colon cancer samples. For these areas, an accurate comparison was made with OCE images and stiffness ranges for morphological structures were obtained. This observation allows us to make a conclusion that OСE can be a promising method for studying the structure of human tissue in clinics.