gebhart/patrepeval huggingface dataset:
PSVIII-22 Effect of nitro-treatment on ruminal metabolism of poultry litter nonprotein nitrogen. (2018)

Poultry litter (PL) is a valuable nitrogen feed source for ruminants whose gut microbes transform the nitrogen in uric acid into microbial protein. Evidence indicates that nitro-treatment may improve the feed value of composted PL by inhibiting degradation of its nonprotein nitrogen (NPN) during composting but it is not known what effect residual nitrocompounds may have on ruminal NPN metabolism. In this study, freshly collected ruminal fluid from a pasture-reared cow was incubated anaerobically (10 mL/tube) at 39oC in closed-culture tubes supplemented with 0.2 g ground alfalfa, 0.15 g of one-year-old PL and with or without 20 mM 3-nitropropionate (NPA) or ethyl nitroacetate (ENA), concentrations previously shown to be inhibitory of uric acid degradation. Analysis of uric acid, urea and ammonia concentrations measured at 0, 6 and 24 h revealed rates of uric acid and urea disappearance in nitro-treated cultures did not differ from controls (0.10, 0.07 and 0.19 µmol urea 0.09, 0.05 and 0.07 µmol uric acid per mL incubation fluid for controls, NPA- and ENA-treated cultures, respectively). Rates of ammonia accumulations in NPA-treated cultures were similar to controls but lower in ENA-treated cultures (0.16, 0.17 and 0.09 µmol/mL, respectively). Effects of nitro-treatment were observed on headspace gas accumulations, although this was not unexpected as the nitrocompounds are known methane-inhibitors. Less gas volume accumulated in NPA- and ENA-treated cultures compared to controls (26, 21 and 18 mL, respectively) and methane production was lower in NPA- and ENA-treated cultures than controls (0.7, 0.5 and 21 µmol/mL, respectively). Hydrogen accumulations were similar between NPA-treated cultures and controls but higher in ENA-treated cultures (0.1, 0.4 and 0.9 µmol/mL, respectively). These results indicate that residual nitrocompounds in nitro-treated PL will have little if any adverse effect on ruminal NPN metabolism and may beneficially contribute to lowering methane emissions.
ChemInform Abstract: NEGATIVELY SUBSTITUTED TRIMETHYLENECYCLOPROPANE DIANIONS (1976)

Abstract Durch Umsetzung von Tetrachlorcyclopropen (I) mit den aktiven Methylenverbindungen (II) werden die zwitterionischen Methylencyclopropene (III) erhalten.
Toric morphisms and fibrations of toric Calabi-Yau hypersurfaces (2002)

Special fibrations of toric varieties have been used by physicists, e.g. the school of Candelas, to construct dual pairs in the study of Het/F-theory duality. Motivated by this, we investigate in this paper the details of toric morphisms between toric varieties. In particular, a complete toric description of fibers -both generic and non-generic -, image, and the flattening stratification of a toric morphism are given. Two examples are provided to illustrate the discussions. We then turn to the study of the restriction of a toric morphism to a toric hypersurface. The details of this can be understood by the various restrictions of a line bundle with a section that defines the hypersurface. These general toric geometry discussions give rise to a computational scheme for the details of a toric morphism and the induced fibration of toric hypersurfaces therein. We apply this scheme to study the family of complex 4-dimensional elliptic Calabi-Yau toric hypersurfaces that appear in a recent work of Braun-Candelas-dlOssa-Grassi. Some directions for future work are listed in the end.
A Chemical Approach to Generate Molecular Diversity Based on the Scaffold of Cyclic Decapeptide Antibiotic Tyrocidine A (2003)

ADVERTISEMENT RETURN TO ISSUEPREVReportNEXTA Chemical Approach to Generate Molecular Diversity Based on the Scaffold of Cyclic Decapeptide Antibiotic Tyrocidine AChuanguang Qin, Xianzhang Bu, Xiaoming Wu, and Zhihong GuoView Author Information Department of Chemistry and Biotechnology Research Institute, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China Cite this: J. Comb. Chem. 2003, 5, 4, 353–355Publication Date (Web):June 13, 2003Publication History Received12 March 2003Published online13 June 2003Published inissue 1 July 2003https://pubs.acs.org/doi/10.1021/cc0300255https://doi.org/10.1021/cc0300255brief-reportACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views604Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Antimicrobial agents,Cyclization,Peptides and proteins,Precursors,Scaffolds Get e-Alerts
Researching of biochemical degradation of electronic materials in fluid electrolytic mediums (2006)

A human body environment has a very composite chemical temper, which includes cations of metals, anions of salts and organic acids. Degradable processes that arise in this medium between biological system and implanted metallic modules chosen as biomaterials by the reason of superior mechanical properties that allow them to be used in load-applications can be harmful and must be explained. The standards ISO 10993 Part 15:2000, Part 17: 2002 and Part 18: 2003 determinate test claims for identification and quantification of bound medical products from metals and alloys; a document of German Institute for Standardization DIN 50905 Part 2: 1987 gives a general guidance on methods of metals corrosion explorations and corrosion testing. Accordingly to these standards investigation of chemical stability of the selected materials (in this case System 1 consist of FR4 with layers of Cu (85 mum) -Ni (6-7mum) -Pd (0.25 mum) -Au (0.06 mum); System 2 consist of Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> substrate with thick film AgPt; System 3 -a silicon wafer, phosphor doted, crystallographic orientation <1 0 0>, thickness 375 mum) under dynamic influence of 0.9% NaCl water solution, synthetic blood plasma (SBF -simulated body fluid) and simulate liquor cerebrospinalis fluid during assigned time in settled conditions have been carried out, processes of surface degradation and alteration have been analyzed.
Towards a Rigorous Assessment of Systems Biology Models: The DREAM3 Challenges (2010)

DREAM provides valuable feedback to practitioners of systems biology modeling. Lessons learned from the predictions of the community provide much-needed context for interpreting claims of efficacy of algorithms described in the scientific literature.
Novel rare genetic variants in idiopathic pulmonary fibrosis (2020)

<b>The study by Nathan and co-workers on rare surfactant protein A genetic variants in patients with familial IPF illustrates the power of rare disease research consortia, and highlights the challenges in developing individualised approaches for IPF patients</b>https://bit.ly/35uC5lw
Molecular analysis of the serotyping antigens of Neisseria meningitidis (1992)

Molecular approaches to the rapid analysis of the serotyping antigens of Neisseria meningitidis, the class 2 and 3 outer membrane proteins (OMPs), were developed, evaluated, and used to study 12 antigenic variants of these proteins. A primer set for the polymerase chain reaction (PCR) amplification of the genes encoding these antigens was devised. Low-stringency amplification of meningococcal chromosomal DNA with this primer set resulted in the amplification of two products from each strain, whereas at higher stringencies only one product was amplified in most strains. Southern hybridization techniques and restriction analyses were used to differentiate the PCR products amplified at high stringencies from strains expressing class 2 or class 3 OMPs; these PCR products were further characterized by the determination of their nucleotide sequences, confirming that they represented the amplified class 2 and class 3 OMP genes. Analyses of these and other nucleotide sequences enabled the construction of a phenogram illustrating the interrelationships between Neisseria OMP genes. The comparative analysis of deduced amino acid sequences revealed conserved and variable regions of the proteins; the latter probably correspond to surface loops on the protein and hence are potentially exposed to the immune system. Further analyses of the primary structures of these related porins from Neisseria species enabled construction of models of the secondary structure of these antigens and comparison of these models with those previously published. The methods reported in the present work are rapid reproducible procedures for the analysis of antigenic variants of these proteins.
Predictors of left ventricular reverse remodeling after percutaneous therapy for mitral regurgitation with the MitraClip system (2020)

LVRR occurs in half of the patients after MC and is associated with reduced MACCE rates at follow-up. Combined information on residual/recurrent MR, baseline LVEF and gender predict LVRR after MC procedure. While residual/recurrent MR is the independent predictor for the absence of LVRR in DMR, in FMR only severe residual TR independently predict LVRR.
Polycyclic polyprenylated acylphloroglucinols: natural phosphodiesterase-4 inhibitors from Hypericum sampsonii (2016)

Seven novel PPAPs and 23 known analogs were isolated from <italic>Hypericum sampsonii</italic>, some of which were identified as potent PDE4 inhibitors.
Transglutaminase in Foods and Biotechnology (2023)

Stabilization and reusability of enzyme transglutaminase (TGM) are important goals for the enzymatic process since immobilizing TGM plays an important role in different technologies and industries. TGM can be used in many applications. In the food industry, it plays a role as a protein-modifying enzyme, while, in biotechnology and pharmaceutical applications, it is used in mediated bioconjugation due to its extraordinary crosslinking ability. TGMs (EC 2.3.2.13) are enzymes that catalyze the formation of a covalent bond between a free amino group of protein-bound or peptide-bound lysine, which acts as an acyl acceptor, and the γ-carboxamide group of protein-bound or peptide-bound glutamine, which acts as an acyl donor. This results in the modification of proteins through either intramolecular or intermolecular crosslinking, which improves the use of the respective proteins significantly.
Supplementary Material for: Superiority in Quality of Life Improvement of Biologics over Conventional Systemic Drugs in a Swiss Real-Life Psoriasis Registry (2017)

<b><i>Background:</i></b> Randomized controlled trials have shown the efficacy of systemic treatments in moderate-to-severe psoriasis. Clinical outcomes in psoriasis patients under real-world conditions are less well understood. <b><i>Objective:</i></b> This study compared Psoriasis Area and Severity Index (PASI) and Dermatological Life Quality Index (DLQI) improvement in all psoriasis patients registered in the Swiss Dermatology Network for Targeted Therapies. We asked whether outcomes differed between 4 treatment strategies, namely biologic monotherapy versus conventional systemic monotherapy, versus combined biologic and conventional systemic drugs, and versus therapy adaptation (switching from one type to another). <b><i>Methods:</i></b> PASI and DLQI within 1 year after onset of systemic treatment, measured at 3, 6, and 12 months, were compared among the 4 groups using generalized linear mixed-effects models. <b><i>Results:</i></b> Between March 2011 and December 2014, 334 patients were included; 151 received conventional systemic therapeutics, 145 biologics, 13 combined treatment, and 25 had a therapy adaptation. With regard to the absolute PASI, neither the biologic cohort nor the combined treatment cohort significantly differed from the conventional systemic therapeutics cohort. The odds of reaching PASI90 was significantly increased with combined therapy compared to conventional systemic therapeutics (<i>p</i> = 0.043) and decreased with a higher body mass index (<i>p</i> = 0.041). At visits 3 and 4, the PASI was generally lower than at visit 2 (visit 3 vs. visit 2, <i>p</i> = 0.0019; visit 4 vs. visit 2, <i>p</i> &lt; 0.001). After 12 months, patients with biologic treatment had a significantly lower DLQI than those with conventional systemic therapeutics (<i>p</i> = 0.001). <b><i>Conclusion:</i></b> This study suggests that after 1 year of treatment, biologics are superior in improving the subjective disease burden compared to conventional systemic drugs.
The Impact of Iron Core Model on Dynamic Behavior of Three-Phase Power Transformer Dynamic Model (2015)

This paper deals with the evaluation of various dynamic models for modeling of three-limb core power transformers. Due to the specific construction of such transformers, the magnetic fluxes in individual core limbs are interdependent. For applications, such as simulations and testing protection devices and algorithms, adequate prediction of inrush currents waveforms is crucial and indispensable. In this paper, various different dynamic models are tested where the limitations of standard models that are available in commercial program packages are pointed out. Two groups of models are evaluated separately: standard three-phase models composed of three-single phase transformer models and advanced three-phase models, where the topology of the magnetic circuit is considered. Furthermore, in both transformer model groups, three different material descriptions are evaluated, where linear, non-linear, and hysteretic material properties are considered. The comparison between measured and calculated waveforms of inrush currents is used to evaluate individual models. The comparison of evaluated models shows that standard dynamic models cannot provide proper waveforms of inrush currents regardless of which magnetically non-linear behavior of the iron core is considered. For adequate modeling of discussed transformers the consideration of the topology of the magnetic circuit is crucial.
A fiber distribution system for microcellular radio (1994)

A new fiber distribution system for mobile phone networks is proposed. In the system, at the base station, a single high power low relative intensity noise Nd:YAG laser is employed and shared by many microcells. At the radio port, an optical coupler is used to split the optical power into two ways: one for the downstream signal detection and the other remodulated by an amplitude modulator for the upstream signal. With proper frequency allocation, some intermodulation distortion can be prevented from falling into the band of the upstream signal. Theoretical analysis shows that this system, in conjunction with thermal noise suppression and modulator linearization techniques, may increase the channel capacity and enhance frequency reuse significantly.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Mechanical Properties of Orbital Fat and Its Encapsulating Connective Tissue (2011)

There is an increasing need to understand the mechanical properties of human orbital fat and its encapsulating connective tissue (OFCT), but such knowledge is not available in the current literature. The purpose of the present study is to examine the mechanical properties of the OFCT. From 5 pairs of 76- to 92-year-old Caucasian human eyes and 33 5- to 7-month-old porcine eyes, 5 human and 11 porcine OFCT samples were dissected at the posterior pole or adjacent to the pole in the vertical, horizontal, and radial directions. Sample dimensions were fixed or measured. Tensile tests were performed on the samples in body-temperature saline. The stress-strain relationship was first approximately linear and then became nonlinear. The linear, the neo-Hookean, and the Mooney-Rivlin constants are reported in Tables 1 and 2. No statistical difference was found among their properties in the different directions in either the human or the porcine samples. Statistical differences were found between the human and the porcine material constants in the horizontal and radial directions. Among our material models, only the Mooney-Rivlin model was able to capture the mechanical properties of the OFCT in large deformation properly. The Mooney-Rivlin model was especially adaptive to the human data. This is the first time the mechanical properties of the human and porcine OFCT have been examined in the literature. We believe our data will provide valuable information to others regarding designing implant biomaterials in orbital treatments and developing computer models to study orbital biomechanics.
ChemInform Abstract: 1,n‐Dicarbanionic Titanium Intermediates from Monocarbanionic Organometallics and Their Application in Organic Synthesis (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fiber Film or Tape Forming Potential of Polyphosphazenes (1989)

Abstract : This report deals with the potential of polyphosphazene homopolymers for their fiber/tape forming ability. Several polymers have been synthesized, characterized and used for this purpose. Key words: Solution NMR, elemental analysis, Gel permeation, Scanning electron microscope, Density.
Abstract PR11: Antigen dominance hierarchies shape tumor T-cell phenotypes and immunotherapy responses (2020)

Abstract In order to drive a productive T-cell response to checkpoint immunotherapy, tumors must be sufficiently antigenic. However, antigens vary in their degree of immunogenicity and consequently drive T-cell responses of different magnitudes and quality. In a genetically engineered mouse model of lung adenocarcinoma expressing model T-cell antigens, we find that antigen dominance hierarchies are established in tumors, where the T-cell response is largely focused on a dominant epitope as observed in viral infections. Interestingly, while T cells responding to a subdominant antigen are fewer in number, we find that they are less exhausted and express more markers of memory cells. T cells responding to the dominant antigen rapidly contract, while those responding to the subdominant antigen persist better over time. Despite their seemingly greater functional potential, T cells responding to the subdominant antigen fail to respond significantly to checkpoint immunotherapy in the context of this dominance hierarchy. Remarkably, removal of the dominant antigen unleashes the subdominant response and these cells expand to fill the effector niche previously occupied by the dominant response. Current experiments are testing the ability of vaccination to “break dominance” and improve the contribution of the subdominant response to tumor control. These findings could have great relevance to the design of personalized cancer vaccines, where targeting subdominant antigens over dominant antigens may lead to surprising therapeutic benefit. This abstract is also being presented as Poster B36. Citation Format: Megan L. Burger, Grace E. Crossland, Jason M. Schenkel, David A. Canner, Tyler Jacks. Antigen dominance hierarchies shape tumor T-cell phenotypes and immunotherapy responses [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology and Immunotherapy; 2019 Nov 17-20; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2020;8(3 Suppl):Abstract nr PR11.
Intramolecular excimer formation of meso- and rac-2,4-di(2-pyrenyl)pentane and meso- and rac-bis[1-(2-pyrenyl)ethyl] ether (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular excimer formation of meso- and rac-2,4-di(2-pyrenyl)pentane and meso- and rac-bis[1-(2-pyrenyl)ethyl] etherP. Collart, S. Toppet, and F. C. De SchryverCite this: Macromolecules 1987, 20, 6, 1266–1271Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/ma00172a018https://doi.org/10.1021/ma00172a018research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Treatment of Aortocoronary Vein Graft Lesions With Membrane-Covered Stents (2000)

Membrane-covered stents appear to be a safe and efficient treatment strategy associated with a low incidence of restenosis and target-vessel revascularization. Compared with previous studies, the investigated device is not associated with an increase in mortality or late vessel occlusions.