gebhart/patrepeval huggingface dataset:
The Metabolism of Chemically Modified Insulins (1978)

Conference Article| June 01 1978 The Metabolism of Chemically Modified Insulins D. PAPACHRISTODOULOU; D. PAPACHRISTODOULOU *Department of Biochemistry, London SE1 7EH, U.K. Search for other works by this author on: This Site PubMed Google Scholar D. BRANDENBURG; D. BRANDENBURG †Deutsches Wollforschungsinstitut, Aachen, Federal Republic of Germany Search for other works by this author on: This Site PubMed Google Scholar D. I. DRON; D. I. DRON *Department of Biochemistry, London SE1 7EH, U.K. Search for other works by this author on: This Site PubMed Google Scholar R. H. JONES; R. H. JONES ‡Department of Medicine, St. Thomas's Hospital Medical School, London SE1 7EH, U.K. Search for other works by this author on: This Site PubMed Google Scholar P. H. SÖNKSEN; P. H. SÖNKSEN ‡Department of Medicine, St. Thomas's Hospital Medical School, London SE1 7EH, U.K. Search for other works by this author on: This Site PubMed Google Scholar J. H. THOMAS J. H. THOMAS *Department of Biochemistry, London SE1 7EH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1978 Biochemical Society1978 Biochem Soc Trans (1978) 6 (3): 555–557. https://doi.org/10.1042/bst0060555 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation D. PAPACHRISTODOULOU, D. BRANDENBURG, D. I. DRON, R. H. JONES, P. H. SÖNKSEN, J. H. THOMAS; The Metabolism of Chemically Modified Insulins. Biochem Soc Trans 1 June 1978; 6 (3): 555–557. doi: https://doi.org/10.1042/bst0060555 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: GSH, reduced glutathione This content is only available as a PDF. © 1978 Biochemical Society1978 Article PDF first page preview Close Modal You do not currently have access to this content.
Ray-tracing algorithms for fast calculation of the channel impulse response on diffuse IR wireless indoor channels (2000)

A modified Monte Carlo algorithm for the calculation of the impulse response on infrared wireless indoor channels is presented. As is well known, the characteristics of the room where the IR diffuse channel is implemented can lead to problems in communication, such as a multipath penalty on the maximum baud rate or hidden-station situations. Classical algorithms require large computational effort to calculate the impulse response in an ordinary-size room. Monte Carlo offers the possibility of validating the assumptions made for these classic algorithms (basically, the Lambertian nature of all reflections) with a computational complexity that is determined by the accuracy desired by the user. We have developed a mixed ray-tracing-deterministic algorithm that assures that each ray contributes to the final channel response function as many times as it rebounds with an obstacle. It increases dramatically the number of contributions and reduces, to the same extent, the time required for an accurate simulation. Extensive simulation results are presented and are compared with those of other simulation methods. We demonstrate that the method presented here is much faster than Monte Carlo classical simulation schemes. It can be used as a method of simulation in itself or as a validation algorithm for other comparative studies of pulse broadening.
Metro area transparent WDM optical networks (2002)

The performance of transparent metropolitan area networks utilizing cost-effective, application-optimized, optical layer components and fiber is discussed. Results for 2.5 Gb/s and 10 Gb/s per channel bit-rates are presented.
Strategy-proof thermal comfort voting in buildings (2014)

Commercial building is a major energy consumer worldwide; and the heating, ventilating and air-conditioning (HVAC) system dominates the total energy consumption. The current practice of the HVAC systems in most commercial buildings is to adopt a fixed temperature setting; and to avoid occupant complaints, building operators usually choose conservative temperatures settings. This leads to massive energy waste; and many times not good in thermal comfort either.
The Ambiguous Fifties (1998)

When the Conservatives came to power under Winston Churchill following the 25 October 1951 elections, half a decade of ambiguity and agonizing about colonial policy ensued. The secretary of state for colonies, Oliver Lyttelton, started off by informing the House of Commons, on 14 November 1951, that the new government would continue the policy of ‘helping the Colonial territories to attain self-government within the British Commonwealth’.1 But Churchill remained a cautious imperialist. His world-view focused on three interlocking circles — the English-speaking peoples, Western Europe, and the Empire/Commonwealth — with Britain in the unique position of being the only participant in all three. His priorities were stated on 29 November 1951: ‘Our first object is the unity and the consolidation of the British Commonwealths and what is left of the former British Empire. Our second, the “fraternal association” of the European-speaking world; and the third, United Europe, to which we are a separate closely — and specially — related friend and ally.’2 In 1954 he was still dreaming of a worthy new Colonial Office building across Parliament Square in Westminster at the ‘Heart of the Empire’.
FireTabletPlus Mobiles Service Interface zu Siemens Brandmeldeanlagen (2011)

Ausgangslage: Siemens Brandmeldeanlagen sind komplexe Systeme, die nicht nur bei der Installation einen sehr hohen Arbeitsaufwand verursachen, sondern auch bei der Instandhaltung und jährlichen Revisionen viel Zeit in Anspruch nehmen. Aus diesem Grund versucht Siemens die dazu nötigen Arbeitsabläufe zu generalisieren und durch technische Hilfsmittel zu unterstützen.Zu diesem Zweck soll das in einer Studienarbeit erstellte Android-Programm FireTablet erweitert und verbessert werden.&#13;\n&#13;\nVorgehen/Technologien: Die vorhandene Software soll in einem ersten Schritt auf Verbesserdungspotential und Erweiterungsmöglichkeiten geprüft werden. Dabei wird in Zusammenarbeit mit unserem Ansprechpartner bei Siemens, gezielt auf die Wünsche des Unternehmens eingegangen. Die Entwicklung konzentriert sich auf die Optimierung des&#13;\ngrafischen Interfaces sowie die Integration der Applikation in den Workflow zur Qualitätssicherung von Brandmeldeanlagen. Um diese Ziele zu erreichen wird weiterhin auf eine Tabletlösung, basierend auf Android, gesetzt. Für die zentrale Datenablage kommt&#13;\nein Webserver zum Einsatz.&#13;\n&#13;\nErgebnis: Mit FireTabletPlus werden Ideen aufgezeigt, die den Arbeitsablauf der regelmässigen Überprüfungen von Brandmeldeanlagen effizienter machen. Die zentral ge-&#13;\nspeicherten Daten einer Anlage können direkt auf das Tablet heruntergeladen werden, wodurch früher erfasste Kommentare und Fehler einsehbar sind. Während des Tests der&#13;\nAnlage unterstützt FireTabletPlus den Servicetechniker durch eine übersichtliche Darstellung&#13;\nder Anlagenstruktur. Feuermelder können auf dem Gebäudeplan markiert und fokusiert werden. Anschliessend können Testergebnisse wieder zentral gespeichert, sowie&#13;\nTestrapporte automatisch generiert und versendet werden. Mit FireTabletPlus können Brandmeldeanlagen sicherer, e�zienter und strukturierter getestet werden.
Investigations on the carcinogenicity of fusarin C — a mutagenic metabolite of Fusarium moniliforme (1986)

The cancer initiating potential of fusarin C, a mutagen produced by Fusarium moniliforme strain MRC 826 was investigated on mouse skin using 12-O-tetradecanoylphorbol-13-acetate as promoter. In neither of these models did fusarin C act as a cancer initiator. Culture material of strain MRC 826, which previously was found to be hepatocarcinogenic in rats, exhibited cancer promoting activity in rat liver using diethylnitrosamine (DEN) as initiator and the induction of gamma glutamyltranspeptidase (GGT)-positive foci as end-point. The culture material of this fungus could also induce the formation of GGT positive foci without DEN initiation. These results seem to indicate that fusarin C is not involved in the hepatocarcinogenic activity of F. moniliforme strain MRC 826.
Offshoring (2010)

The changing economic and labor conditions have motivated firms to outsource professional services activities to skilled personnel in less expensive labor markets. This offshoring phenomenon is studied from a political, economic, technological and strategic perspective. Next, an analytical model is developed for achieving strategic advantage from offshoring based on global partnerships. The model studies the impact of offshoring with respect to the complexity and strategic nature of the tasks and presents a decision strategy for obtaining value through offshoring of increasingly complex tasks. The result is an integrated “24-hour knowledge factory” that is based on a sustainable global model rather than a short term fiscal model. This 24-hour paradigm embodies the shift-style workforce that evolved for the manufacturing sector during the Industrial Revolution and relies on a set of critical success factors in the current environment. A case example is provided from IBM to illustrate these underlying critical success factors.
ChemInform Abstract: Asymmetric Synthesis of trans‐2,3‐Piperidinedicarboxylic Acid and trans‐3,4‐Piperidinedicarboxylic Acid Derivatives. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The cleaning method selected for new PEX pipe installation can affect short-term drinking water quality (2015)

The influence of four different cleaning methods used for newly installed polyethylene (PEX) pipes on chemical and odor quality was determined. Bench-scale testing of two PEX (type b) pipe brands showed that the California Plumbing Code PEX installation method does not maximize total organic carbon (TOC) removal. TOC concentration and threshold odor number values significantly varied between two pipe brands. Different cleaning methods impacted carbon release, odor, as well the level of drinking water odorant ethyl tert-butyl ether. Both pipes caused odor values up to eight times greater than the US federal drinking water odor limit. Unique to this project was that organic chemicals released by PEX pipe were affected by pipe brand, fill/empty cycle frequency, and the pipe cleaning method selected by the installer.
Advances in optical access networks (2006)

The EPON (Ethernet passive optical network) standard (IEEE 802.3ah) only covers physical and data link layers; the rest is considered out-of-scope. This article explores several interesting research problems brought forward by the EPON architecture, but left out by the standard.
Low Pressure Chemical Vapor Deposition of Tantalum Silicide (1986)

A process for the low pressure chemical vapor deposition (LPCVD) of tantalum disilicide is described. The process sequence requires the deposition of undoped polysilicon followed by the deposition of tantalum silicide in a single reactor. The chemistry involves the reaction of with to produce a tantalum rich silicide , and a competing reaction of with solid silicon to produce . The tantalum rich silicide phase reacts with the underlying polysilicon during the deposition process and during a post‐deposition anneal to form the silicon saturated phase . The three reactions (a displacement reaction, a silane reaction, and an interdiffusion reaction) compete to determine the film stoichiometry, microstructure, and interface roughness. The LPCVD tantalum silicide microstructure can have fine or coarse grains depending on the tantalum chloride to silane ratio, and silicon whiskers can appear at high ratios of silane to tantalum chloride.
Sex and the New Woman in "The Golden Notebook" (1974)

Doris Lessing is not a feminist, and The Golden Notebook is not a feminist novel ?Lessing's remarks outside her fiction have been numerous and emphatic enough finally convince everyone of these facts.1 But the reasons for a great deal of confusion in the not-so-distant past about the aims of The Golden Notebook are extremely significant, for this novel provides more insight into the lineaments of liberation than any other contemporary work by and about women. Women read Lessing with the same intensity and anxiety that accompany their own philoso phical and pragmatic struggles create a new, viable selfhood. As Alison Lurie says, we come Lessing to find out, first, How it really is, and second, What do about it.2 Because The Golden Notebook asks all the questions that obsess women striving for liberation, it seems imperative find out why Lessing has tried suggest only some of the answers. Moreover, what Lessing considers the novel's true subject?the relation between the individual and his society?far from denying its feminist value only increases its relevance the contemporary women's movement. For women have been dehumanized and victimized largely because of the limitations of their sanctioned social roles and their remoteness from the larger political context in which they exist. If they are emerge as fully developed individuals they must learn establish their own relation the world without relying on men as intermediaries. As a novelist Lessing is famous (in some eyes, infamous) for her inclusiveness, and The Golden Notebook is the last and greatest of her novels be fully inclu sive. While the book explores in detail and in depth virtually every situation, idea and feeling that may involve a woman, Anna herself inquires into all of the world, all of life. The reader who is herself striving be genuinely intellectual as well as liberated feels that she has a true counterpart in Anna, a companion who is in
Alzheimer Amyloid Protein Precursor Is Localized in Nerve Terminal Preparations to Rab5-containing Vesicular Organelles Distinct from Those Implicated in the Synaptic Vesicle Pathway (1996)

In order to localize amyloid protein precursor (APP) in nerve terminals, we have immunoisolated vesicular organelles from nerve terminal preparations using antibodies to Rab5 and synaptophysin. These immunoisolates were then analyzed by electron microscopy and by immunoblotting. The synaptophysin immunoisolates represented a nearly homogeneous population of small synaptic vesicles, with less than 10% contamination by other organelles, and very little APP. In contrast, Rab5 immunoisolates contained, in addition to small synaptic vesicles, substantial numbers of large uni- and bilamellar vesicles and high levels of APP. Thus, it appears that nerve terminal APP is contained predominantly in large vesicular organelles, distinct from synaptic vesicles and from the synaptic vesicle recycling pathway.
Global development and adaptive behaviour in children with early‐onset epilepsy: a population‐based case–control study (2018)

Children with early-onset epilepsy are at significant risk of intellectual disability. Developmental impairment is associated with use of polytherapy but not with any seizure parameters. Developmental profiles in young children with epilepsy differ from other conditions.
[Non-invasive brain stimulation for the treatment of depression]. (2020)

Depression is one of the most common psychiatric disorders and is a heavy burden, not only for the patient and his or her environment but also in economic and social terms. 35% of depressed patients do not recover after standard treatment with medication or psychotherapy. There is a need for more effective treatment options for depression. In recent decades, new forms of brain stimulation have been developed for the treatment of depression, the most important of which is transcranial magnetic stimulation (TMS). TMS uses magnetic pulses to influence brain activity. Meta-analyses show approximately 30-40% of patients respond to treatment with repetitive TMS. The depression goes into remission in about 20-30% of cases. Research has led to new treatment protocols and variations on the conventional TMS method. More research into the effectiveness of these developments is needed. We recommend using TMS as an add-on treatment more often when the patient has completed two steps of the treatment guideline.
Introduction to redundant arrays of inexpensive disks (RAID) (2003)

The authors discuss various types of RAIDs (redundant arrays of inexpensive disks), a cost-effective option to meet the challenge of exponential growth in the processor and memory speeds. They argue that the size reduction of personal-computer (PC) disks is the key to the success of disk arrays. While large arrays of mainframe processors are possible, it is certainly easier to construct an array from the same number of microprocessors (or PC drives). With advantages in cost-performance, reliability, power consumption, and floor space, the authors expect RAIDs to replace large drives in future I/O systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
An overlap-contention free true-single-phase clock dual-edge-triggered flip-flop (2015)

Dual-edge-triggered (DET) synchronous operation is a very attractive option for low-power, high-performance designs. Compared to conventional single-edge synchronous systems, DET operation is capable of providing the same throughput at half the clock frequency. This can lead to significant power savings on the clock network that is often one of the major contributors to total system power. However, in order to implement DET operation, special registers need to be introduced that sample data on both clock-edges. These registers are more complex than their single-edge counterparts, and often suffer from a certain amount of clock-overlap between the main clock and the internally generated inverted clock. This overlap can cause contention inside the cell and lead to logic failures, especially when operating at scaled power supplies and under process variations that characterize nanometer technologies. This paper presents a novel, static DET flip-flop (DET-FF) with a true-single-phase clock that completely avoids clock overlap hazards by eliminating the need for an inverted clock edge for functionality. The proposed DET FF was implemented in a standard 40nm CMOS technology, showing full functionality at low-voltage operating points, where conventional DET-FFs fail. Under a near-threshold, 500mV supply voltage, the proposed cell also provides a 35% lower CK-to-Q delay and the lowest power-delay-product compared to all considered DET-FF implementations.
Analyse et optimisations de transistors à effet de champ à hétérojonction pour l'amplification de puissance dans la bande Ka (1995)

L'amelioration permanente des performances des transistors a effet de champ, en termes de frequence, puissance ou rendement, a conduit ces composants a remplacer progressivement les tubes a vide dans les amplificateurs hyperfrequences. De plus, depuis quelques annees, l'extraordinaire explosion des applications grand public comprenant des circuits de puissance hyperfrequences (radiocommunication sans fil, telecommunications par satellite, systemes d'anti-collision, d'auto-peage, et de surveillance de la circulation) a renforce cette tendance. La premiere partie de ce travail developpe une methode de caracterisation specifique en statique et en hyperfrequence petit signal des transistors a effet de champ millimetriques en vue d'une utilisation en puissance. Des analyses sont effectuees afin de determiner les principales limitations de ces composants. Des solutions sont envisagees afin d'ameliorer leurs performances. La suite du travail porte sur la caracterisation de ces transistors en fonctionnement grand signal dans la bande de frequence 26-40 GHz a partir de bancs de mesures en puissance classiques. L'etude continue avec une recherche de l'influence des polarisations drain source et grille source et du developpement total de grille sur les comportements en puissance des composants. La derniere partie presente un systeme automatise de mesures grand signal dans la bande Ka qui permet d'effectuer des mesures en mode load pull a charge active ou en analyseur de reseau standard et d'avoir acces a toutes les grandeurs caracteristiques (gains, puissances, rendements). Ces mesures et analyses ont pour objectifs l'amelioration de la technologie pour les applications de puissance et la validation des modeles non lineaires utilises pour la conception de circuits hybrides ou monolithiques.
Targeted Nanoswitchable Inhibitors of Protein–Protein Interactions Involved in Apoptosis (2018)

Progress in drug delivery is hampered by a lack of efficient strategies to target drugs with high specificity and precise spatiotemporal regulation. The remote control of nanoparticles and drugs with light allows regulation of their action site and dosage. Peptide-based drugs are highly specific, non-immunogenic, and can be designed to cross the plasma membrane. In order to combine target specificity and remote control of drug action, here we describe a versatile strategy based on a generalized template to design nanoswitchable peptides that modulate protein-protein interactions upon light activation. This approach is demonstrated to promote photomodulation of two important targets involved in apoptosis (the interactions Bcl-xL-Bak and MDM2-p53), but can be also applied to a large pool of therapeutically relevant protein-protein interactions mediated by α-helical motifs. The template can be adjusted using readily available information about hot spots (residues contributing most to the binding energy) at the protein-protein interface of interest.
Influence of light absorption on the performance characteristics of UV LEDs with emission between 239 and 217 nm (2019)

The development of ultraviolet AlGaN multiple quantum well (MQW) light emitting diodes (LEDs) in the wavelength range between 239 and 217 nm is presented. The effects of aluminum composition in the MQW active region and of the underlying AlxGa1−xN:Si current spreading layer on the emission characteristics and operating voltages are investigated. A strong reduction in output power is observed with decreasing emission wavelength which is partly attributed to light absorption within the underlying AlxGa1−xN:Si. Additionally, a reduced carrier injection efficiency is identified as the root cause for the reduced emission power with decreasing emission wavelength. Emission powers at a dc current of 20 mA between 310 and 0.15 μW have been achieved for LEDs emitting between 239 and 217 nm. The maximum light output in pulsed mode operation of these LEDs ranged between 4.6 mW and 3.6 μW, respectively.