gebhart/patrepeval huggingface dataset:
Voxel-Based Interactive Haptic Simulation of Dental Drilling (2009)

Haptics is one of the most important sensations for dentists to prepare cavity in dental surgery, which is however not easy to simulate in a computer system because of the large drilling force and the small speed of movement and material removal. In this paper, we present a fully voxel-based approach to interactively simulate dental drilling. Different from those voxel/mesh hybrid models, the drilling forces are computed directly from the voxel-representation while considering the factors of teeth’s material properties, the posture and forward speed of dentist’s drill and the contact surface area. To overcome force discontinuity caused by removal of tooth material, we define two layers of voxels on drill, where the boundary voxels are only employed to compute force feedback and the interior voxels are adopted to remove materials from teeth. The experimental result shows that our force model can produce smooth and large force feedback at a slow movement on haptic devices. Other than haptic rendering, a real-time filtering method directly using voxel representation has also been developed to improve visual rendering in dental simulation.
Team-It: location-based mobile games for multi-agent coordination and negotiation (demonstration) (2012)

The multi-agent systems community has made great strides investigating issues such as coordination and negotiation. When addressing human or human-agent behavior, very few approaches have addressed a feature that people are embodied in the real-world and act in geospatial environments. In the past, it has been difficult to perform experiments and collect data for such domains. However, with the spread of mobile technology that can run sophisticated applications and return location-based data, we are now in a position to investigate such questions.
Disruption of microtubules in plants suppresses macroautophagy and triggers starch excess-associated chloroplast autophagy (2015)

Microtubules, the major components of cytoskeleton, are involved in various fundamental biological processes in plants. Recent studies in mammalian cells have revealed the importance of microtubule cytoskeleton in autophagy. However, little is known about the roles of microtubules in plant autophagy. Here, we found that ATG6 interacts with TUB8/β-tubulin 8 and colocalizes with microtubules in Nicotiana benthamiana. Disruption of microtubules by either silencing of tubulin genes or treatment with microtubule-depolymerizing agents in N. benthamiana reduces autophagosome formation during upregulation of nocturnal or oxidation-induced macroautophagy. Furthermore, a blockage of leaf starch degradation occurred in microtubule-disrupted cells and triggered a distinct ATG6-, ATG5- and ATG7-independent autophagic pathway termed starch excess-associated chloroplast autophagy (SEX chlorophagy) for clearance of dysfunctional chloroplasts. Our findings reveal that an intact microtubule network is important for efficient macroautophagy and leaf starch degradation.
Phase Behavior of Sparingly Soluble Polyethoxylate Monolayers at the Air−Water Surface and Its Effect on Dynamic Tension (1998)

We present the monolayer phase behavior of several slightly water-soluble linear poly(ethylene glycol) alkyl ether surfactants (CiEj = CH3(CH2)i-1−(O(CH2)2)jOH) and the relationship between the adsorbed monolayer phases, their transitions, and the rate of surface tension reduction. Surface pressure isotherms suggest a first-order phase transition between liquid expanded (L1) and liquid condensed (L2) states for the least soluble amphiphiles: C12E0, C14E1, and C16E2, with transition surface pressures near 20 mN/m at room temperature. In addition, C14E1 isotherms show a possible vertical LS state at higher pressure but below its equilibrium spreading pressure of 46 mN/m. Fluorescence microscopy of spread C14E1 monolayers confirms L1−L2 phase coexistence and reveals coexistence between liquid expanded and gaseous (G) states at low surface pressure. The dynamic assembly of these phases from solution, induced by flow in the subphase, is visualized with fluorescence and monitored with surface tension measurements; results compare well with spread monolayers. These observations show that as surfactant adsorbs to an initially clean air−water interface and phase transitions occur, coexistence gives rise to tension plateaus consistent with those measured for spread monolayers by surface compression. We confirm these results with C14E1 pendant bubble dynamic tension measurements, where the observed pronounced induction period represents G−L1 coexistence, and the intermediate plateau results from an L1−L2 transition.
Data from PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Most patients with prostate cancer treated with androgen receptor (AR) signaling inhibitors develop therapeutic resistance due to restoration of AR functionality. Thus, there is a critical need for novel treatment approaches. Here we investigate the theranostic potential of hu5A10, a humanized mAb specifically targeting free PSA (&lt;i&gt;KLK3&lt;/i&gt;).&lt;/p&gt;Experimental Design:&lt;p&gt;LNCaP-AR (LNCaP with overexpression of wildtype AR) xenografts (NSG mice) and &lt;i&gt;KLK3&lt;/i&gt;_Hi-&lt;i&gt;Myc&lt;/i&gt; transgenic mice were imaged with &lt;sup&gt;89&lt;/sup&gt;Zr- or treated with &lt;sup&gt;90&lt;/sup&gt;Y- or &lt;sup&gt;225&lt;/sup&gt;Ac-labeled hu5A10; biodistribution and subcellular localization were analyzed by gamma counting, PET, autoradiography, and microscopy. Therapeutic efficacy of [&lt;sup&gt;225&lt;/sup&gt;Ac]hu5A10 and [&lt;sup&gt;90&lt;/sup&gt;Y]hu5A10 in LNCaP-AR tumors was assessed by tumor volume measurements, time to nadir (TTN), time to progression (TTP), and survival. Pharmacokinetics of [&lt;sup&gt;89&lt;/sup&gt;Zr]hu5A10 in nonhuman primates (NHP) were determined using PET.&lt;/p&gt;Results:&lt;p&gt;Biodistribution of radiolabeled hu5A10 constructs was comparable in different mouse models. Specific tumor uptake increased over time and correlated with PSA expression. Treatment with [&lt;sup&gt;90&lt;/sup&gt;Y]/[&lt;sup&gt;225&lt;/sup&gt;Ac]hu5A10 effectively reduced tumor burden and prolonged survival (&lt;i&gt;P&lt;/i&gt; ≤ 0.0054). Effects of [&lt;sup&gt;90&lt;/sup&gt;Y]hu5A10 were more immediate than [&lt;sup&gt;225&lt;/sup&gt;Ac]hu5A10 (TTN, &lt;i&gt;P&lt;/i&gt; &lt; 0.0001) but less sustained (TTP, &lt;i&gt;P&lt;/i&gt; &lt; 0.0001). Complete responses were observed in 7 of 18 [&lt;sup&gt;225&lt;/sup&gt;Ac]hu5A10 and 1 of 9 mice [&lt;sup&gt;90&lt;/sup&gt;Y]hu5A10. Pharmacokinetics of [&lt;sup&gt;89&lt;/sup&gt;Zr]hu5A10 were consistent between NHPs and comparable with those in mice. [&lt;sup&gt;89&lt;/sup&gt;Zr]hu5A10-PET visualized the NHP-prostate over the 2-week observation period.&lt;/p&gt;Conclusions:&lt;p&gt;We present a complete preclinical evaluation of radiolabeled hu5A10 in mouse prostate cancer models and NHPs, and establish hu5A10 as a new theranostic agent that allows highly specific and effective downstream targeting of AR in PSA-expressing tissue. Our data support the clinical translation of radiolabeled hu5A10 for treating prostate cancer.&lt;/p&gt;&lt;/div&gt;
Guided and standing Bloch waves in periodic elastic strips (2009)

Elastic waveguiding structures are investigated for guides constructed of periodically alternating media thereby forming a striped waveguide. The guide has finite width with either homogeneous traction-free or clamped boundary conditions on the guide walls, or a combination of these. The band spectrum and associated Floquet–Bloch eigensolutions for these in-plane elastic waveguides are identified. Several features of this guiding structure emerge, and are of interest; in some cases a total stop band at zero frequency is identified providing space for low frequency localized modes: such modes also appear when we create defects in the structured waveguide. The dispersion curves often have maxima and minima of the spectral edges far from the edges of the Brillouin zone and these are related to slow sound or standing waves within the structure. Numerical and asymptotic techniques are developed and discussed, the latter are based on weak contrast, and weak geometric changes, or utilize jump conditions in limits where one medium is thin relative to the other. There are technological applications that could utilize this theory and we demonstrate that imaging is possible using anomalous dispersion.
Best Practices in Mentoring Student Researchers: A Panel Discussion (2008)

UCF faculty from a variety of disciplines will discuss strategies and best practices with regard to mentoring undergraduates in research and creative endeavors. The panel will answer questions about mentoring student researchers with regard to getting started in research, setting deadlines and goals, preparing presentations, writing, and preparing students for graduate school.
Preferential Association of Human Papillomavirus With High-Grade Histologic Variants of Penile-Invasive Squamous Cell Carcinoma (1995)

Journal Article Preferential Association of Human Papillomavirus With High-Grade Histologic Variants of Penile-Invasive Squamous Cell Carcinoma Get access Lucie Gregoire, Lucie Gregoire Department of Obstetrics and Gynecology, Wayne State University School of MedicineDetroit, MI Search for other works by this author on: Oxford Academic PubMed Google Scholar Antonio L. Cubilla, Antonio L. Cubilla Instituto de Anatomía Patológica, Universidad Nacional de AsunciónAsunción, Paraguay Search for other works by this author on: Oxford Academic PubMed Google Scholar Victor E. Reuter, Victor E. Reuter Department of Pathology, Memorial Sloan-Kettering Cancer CenterNew York, NY Search for other works by this author on: Oxford Academic PubMed Google Scholar Gabriel P. Haas, Gabriel P. Haas Department of Urology, Wayne State University School of MedicineDetroit, MI Search for other works by this author on: Oxford Academic PubMed Google Scholar Wayne D. Lancaster Wayne D. Lancaster Department of Obstetrics and Gynecology and Center for Molecular Medicine and Genetics, Wayne State University School of MedicineDetroit, MI Wayne D. Lancaster, Ph.D., Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 540 East Canfield Ave., Detroit, MI 48201. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 22, 15 November 1995, Pages 1705–1709, https://doi.org/10.1093/jnci/87.22.1705 Published: 15 November 1995 Article history Received: 20 April 1995 Revision received: 23 August 1995 Accepted: 31 August 1995 Published: 15 November 1995
Oxidation of Cyclohexene to trans-1,2-Cyclohexanediol Promoted by p-Toluenesulfonic Acid without Organic Solvents (2011)

This experiment describes a method for cyclohexene oxidation to trans-1,2-cyclohexanediol using p-toluenesulfonic acid (p-TsOH) as promoter and hydrogen peroxide as oxidant in a biphasic system. This method allows conversions up to 97.9% (monitored by 1H NMR). trans-1,2-Cyclohexanediol was not easily separated from the aqueous solution owing to formation of an azeotropic mixture with water. Destruction of the azeotropic mixture was observed in the presence of sodium p-toluenesulfonate salt (p-TsONa). Therefore, water could be removed by simple distillation after p-TsOH neutralization. Purification of trans-1,2-cyclohexanediol was accomplished by sublimation. The overall reaction, separation, and purification experiment did not require any organic solvent.
Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells (2015)

Tumour stromal macrophages differentiate to tumour-associated macrophages (TAMs) with characteristics of immunosuppressive M2-type macrophages, having a central role in promoting tumour vascularisation, cancer cell dissemination and in suppressing anti-cancer immune responses. Bisphosphonates (BPs) are a group of drugs commonly used as anti-resorptive agents. Further, nitrogen containing BPs like Zoledronate (ZOL), are known to cause unspecific inflammatory reactions hence the hypothesis that its use could modulate TAMs polarization toward a more inflammatory phenotype. We studied the in vitro polarization of J774 murine macrophages upon culture in 4T1 breast cancer cell-conditioned medium (4T1CM) and stimulation with LPS and free and liposome-encapsulated bisphosphonates. In this system, breast cancer soluble factors reduced the pro-inflammatory activation of macrophages but increased the secretion of matrix metalloproteinases (MMPs). In the presence of 4T1CM, a non-cytotoxic dose of liposome-encapsulated ZOL (ZOL-LIP) enhanced the expression of iNOS and TNF-α, markers of M1 activation, but did not diminish the expression of M2-type markers. In contrast, clodronate treatment either as a free drug (CLO) or liposome-encapsulated (CLO-LIP) decreased the expression of the M1-type markers and was highly cytotoxic to the macrophages. Breast cancer cells soluble factors modulate macrophages toward M2 activation state. Bisphosphonates may be applied to counteract this modulation. We propose that ZOL-LIP may be suitable for favouring cytotoxic immune responses by TAMs in breast cancer, whereas CLO-LIP may be appropriate for TAM depletion.
OPENING-WEDGE OSTEOTOMY FOR REVISION OF FAILED CLOSING-WEDGE HIGH TIBIAL OSTEOTOMY (2004)

Tsuda, Eiichi MD; Ishibashi, Yasuyuki MD; Sasaki, Kazuhiro MD; Sato, Hideki MD; Toh, Satoshi MD Author Information
Nucleoporin-regulated MAP kinase signaling in immunity to a necrotrophic fungal pathogen (2016)

Pathogen-responsive mitogen-activated protein kinase (MAPK or MPK) cascades relay signals from activated immune receptors across the nuclear envelope to intranuclear targets. However, in plants, little is known about the spatial control of MAPK signaling. Here, we report that the Arabidopsis (Arabidopsis thaliana) nuclear pore complex protein Nup88/MOS7 is essential for immunity to the necrotrophic fungus Botrytis cinerea The mos7-1 mutation, causing a four-amino acid deletion, compromises B. cinerea-induced activation of the key immunoregulatory MAPKs MPK3/MPK6 and reduces MPK3 protein levels posttranscriptionally. Furthermore, MOS7 contributes to retaining a sufficient MPK3 abundance in the nucleus, which is required for full immunity to B. cinerea Finally, we present a structural model of MOS7 and show that the mos7-1 mutation compromises interactions with Nup98a/b, two phenylalanine-glycine repeat nucleoporins implicated in maintaining the selective nuclear pore complex permeability barrier. Together, our analysis uncovered MOS7 and Nup98 as novel components of plant immunity toward a necrotrophic pathogen and provides mechanistic insights into how these nucleoporins coordinate nucleocytoplasmic transport to mount a robust immune response.
A skin friction balance using air bearings (1970)

In this note a new type of skin friction balance is described. The elemental surface in the balance is floated on an air bearing and the skin friction force is resisted by a spring, the deflection of which is determined by a position sensor. The balance may be adaptable to different surface geometries and used for unsteady as well as steady flows.
Baseline Assessment of Circulating MicroRNAs Near Diagnosis of Type 1 Diabetes Predicts Future Stimulated Insulin Secretion (2020)

Type 1 diabetes is an autoimmune disease resulting in severely impaired insulin secretion. We investigated whether circulating microRNAs (miRNAs) are associated with residual insulin secretion at diagnosis and predict the severity of its future decline. We studied 53 newly diagnosed subjects enrolled in placebo groups of TrialNet clinical trials. We measured serum levels of 2,083 miRNAs, using RNA sequencing technology, in fasting samples from the baseline visit (<100 days from diagnosis), during which residual insulin secretion was measured with a mixed meal tolerance test (MMTT). Area under the curve (AUC) C-peptide and peak C-peptide were stratified by quartiles of expression of 31 miRNAs. After adjustment for baseline C-peptide, age, BMI, and sex, baseline levels of miR-3187-3p, miR-4302, and the miRNA combination of miR-3187-3p/miR-103a-3p predicted differences in MMTT C-peptide AUC/peak levels at the 12-month visit; the combination miR-3187-3p/miR-4723-5p predicted proportions of subjects above/below the 200 pmol/L clinical trial eligibility threshold at the 12-month visit. Thus, miRNA assessment at baseline identifies associations with C-peptide and stratifies subjects for future severity of C-peptide loss after 1 year. We suggest that miRNAs may be useful in predicting future C-peptide decline for improved subject stratification in clinical trials.
Evaluation of the geometric phase of a two-level atom manipulated on the Bloch sphere using a time-domain atom interferometer (2007)

The geometric manipulation of the quantum states of two-level atoms with two laser-controlled resonant $\ensuremath{\pi}$ pulses with a relative phase difference was evaluated using a time-domain atom interferometer comprising a cold sodium atom ensemble and two copropagating two-photon Raman pulses. It was verified that the relative phase shift between two states is double the control phase difference and that the rotation around the axis 3 of the Bloch sphere can be controlled by geometric manipulation.
Purification in an active form of the phage ø29 protein p4 that controls the viral late transcription (1987)

The phage phi 29 protein p4, that controls viral late transcription, was highly purified from Escherichia coli cells harbouring a gene 4-containing plasmid. This protein, representing about 6% of the total cellular protein, was obtained in a highly purified form. The protein was characterized as p4 by amino acid analysis and NH2-terminal sequence determination. The purified protein was active in an in vitro transcription assay, allowing specific initiation of transcription at the phi 29 A3 late promoter in the presence of Bacillus subtilis sigma 43-RNA polymerase holoenzyme.
URL Problem Statement and Directions (2015)

This document lays out the problem space of possibly conflicting
standards between multiple organizations for URLs and things like
them, and proposes some actions to resolve the conflicts. From a user
or developer point of view, it makes no sense for there to be a
proliferation of definitions of URL nor for there to be a
proliferation of incompatible implementations. This shouldn't be a
competitive feature. Therefore there is a need for the organizations
involved to update and reconcile the various Internet Drafts,
Recommendations, and Standards in this area.
Hydrogenated Amorphous Silicon—Material Properties and Device Applications (2006)

This chapter contains sections titled: Introduction Preparation and Structural Properties of Amorphous Silicon Density of States Distribution in the Energy Gap Optical Properties Transport Properties Recombination of Excess Carriers Device Applications Thin-film Solar Cells References
[Antibiotic-impregnated prostheses: eclectic indications]. (1996)

Based on the findings in this series, antibiotic impregnated stents should be indicated only in selected patients due to the extra cost: past history of local infection, ruptured aneurysms, femoro-tibial stents, cross or axillo-femoral revascularization for which the rate of stent infection is 6.3 - 3.2 and 1.4%, immunodeficient patients, multiple reoperations, post-irradiation arteritis and situations known to involve major risk of infection.
Conservative management of gastric emphysema with hepatoportal venous gas (2015)

A 43-year-old man with a history of viral hepatitis and active intravenous drug use presented with a 4-day history of severe nausea and coffee-ground emesis, followed by acute onset of colicky abdominal pain and non-bloody diarrhoea. On examination, he was tachycardic, but otherwise haemodynamically stable and afebrile. There was tenderness in the right upper quadrant, with no rebound or guarding and bowel sounds were normoactive. Initial laboratory investigations revealed raised urea of 24 mM/L, normal lactate and no leucocytosis.

A CT of the abdomen and pelvis with contrast revealed gastric pneumatosis (figure 1) with hepatoportal venous gas (HPVG; figure 2) and signs of parenchymal …
Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis (2020)

Visceral leishmaniasis (VL) affects millions of people across the world, largely in developing nations. It is fatal if left untreated and the current treatments are inadequate. As such, there is an urgent need for new, improved medicines. In this paper, we describe the identification of a 6-amino-<i>N</i>-(piperidin-4-yl)-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidine scaffold and its optimization to give compounds which showed efficacy when orally dosed in a mouse model of VL.
Optical properties of diamond-like carbon synthesized by plasma immersion ion processing (1999)

Hard and transparent diamond-like carbon (DLC) films have been prepared on low temperature substrates by using the C2H2-Ar plasma immersion ion processing (PIIP) method. The optical properties of the DLC films deposited on poly(methylmethacrylate) (PMMA), silicon wafers, and glass plates were systematically examined. It was found that careful control of substrate bias was needed for favorable growth of DLC films with low atomic hydrogen contents, high hardness and mass densities, and excellent optical properties. The resultant DLC films exhibited a high hardness of above 22 GPa, an optical gap energy larger than 1.9 eV, a low refractive index of 1.87, and very high optical transmittance in the visible light range. The study confirmed that C2H2-Ar PIIP with low negative bias voltages and suitable C2H2/Ar gas ratios can process optically transparent and hard protective DLC films on PMMA plastics.
Die TGK-Novelle 2012 (2012)

Am 10.05.2012 ist das zur Aenderung telekommunikationsrechtlicher (TKG-AendG) in Kraft getreten: Die damit vorgenommene Novellierung des Telekommunikationsgesetzes (TKG) dient der Umsetzung eines im Herbst 2009 verabschiedeten Pakets von europarechtlichen Aenderungsrichtlinien zur Regulierung elektronischer Kommunikationsnetze und -dienste. Darueber hinaus enthaelt das Gesetz eine Reihe von Regelungen zu aktuellen nationalen regulierungs- und verbraucherschutzrechtlichen Themen. Nach einem langen und kontroversen Rechtsetzungsverfahren verabschiedete der Rat am 25.11.2009 zwei Aenderungsrichtlinien, mit denen der im Jahr 2002 geschaffene europarechtliche Rahmen fuer elektronische Kommunikationsnetze und -dienste umgestaltet wurde. Vorrangige Zielsetzung des Reformpakets 2009 war es, die Wettbewerbsentwicklung auf dem europaeischen Binnenmarkt und den Ausbau neuer, hochleistungsfaehiger Netze der elektronischen Kommunikation zu staerken und Anreize fuer Investitionen in neue Hochgeschwindigkeitsnetze zu schaffen, die europaeische Harmonisierung voranzutreiben und die Verbraucherrechte im Bereich des Kunden- und Datenschutzes sowie der Datensicherheit zu verbessern. Das EU-Reformpaket war bis zum 25.05.2011 in nationales Recht umzusetzen. Die Paragrafen 77c bis 77e TKG raeumen Betreibern oeffentlicher Telekommunikationsrechte Rechte zur Mitbenutzung solcher oeffentlicher Infrastrukturen (Bundesfernstrassen, Bundeswasserstrassen, oeffentlichen Eisenbahninfrastrukturen) ein, die zum Aus- und Aufbau von Netzen der naechsten Generation genutzt werden koennen. (A)