gebhart/patrepeval huggingface dataset:
Detection of Circulating Tumor Cells Using Membrane-Based SERS Platform: A New Diagnostic Approach for ‘Liquid Biopsy’ (2019)

The detection and monitoring of circulating tumor cells (CTCs) in blood is an important strategy for early cancer evidence, analysis, monitoring of therapeutic response, and optimization of cancer therapy treatments. In this work, tailor-made membranes (MBSP) for surface-enhanced Raman spectroscopy (SERS)-based analysis, which permitted the separation and enrichment of CTCs from blood samples, were developed. A thin layer of SERS-active metals deposited on polymer mat enhanced the Raman signals of CTCs and provided further insight into CTCs molecular and biochemical composition. The SERS spectra of all studied cells-prostate cancer (PC3), cervical carcinoma (HeLa), and leucocytes as an example of healthy (normal) cell-revealed significant differences in both the band positions and/or their relative intensities. The multivariate statistical technique based on principal component analysis (PCA) was applied to identify the most significant differences (marker bands) in SERS data among the analyzed cells and to perform quantitative analysis of SERS data. Based on a developed PCA algorithm, the studied cell types were classified with an accuracy of 95% in 2D PCA to 98% in 3D PCA. These results clearly indicate the diagnostic efficiency for the discrimination between cancer and normal cells. In our approach, we exploited the one-step technology that exceeds most of the multi-stage CTCs analysis methods used and enables simultaneous filtration, enrichment, and identification of the tumor cells from blood specimens.
Exact method for numerically analyzing a model of local denaturation in superhelically stressed DNA (1999)

Received 9 December 1997
Editorial (2008)

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A Review of Ring Staple Yarn Spinning Method Development and Its Trend Prediction (2013)

In this article, ring staple single yarn spinning method development has been reviewed after an introductory background about ring spinning principle and ring staple yarn defect problems. The review concludes that previous novel ring staple spinning methods have been developed mainly on a basis of staple spinning strand control enhancements by means of separating single strands into two or several subones, concentrating triangular ring spinning strand, rewrapping protruding fiber ends, and improving online twisting density distribution. Reputed novel ring spinning technologies are included in this review such as siro-spinning, solo-spinning, compact spinning, air-jet spinning, air-suction spinning, and Nu-torque yarn spinning. The inadequacy of some reviewed novel spinning methods is considered as a motility of ring spinning method further development. It is predicted that ring staple spinning can be further developed via increasing spinning efficiency and improving online spinning strand properties.
CFD Studies on Wind Turbine Interactions with the Turbulent Local Flow Field Influenced by Complex Topography and Thermal Stratification (2021)

Abstract. This paper shows the results of CFD studies of turbulent flow fields and their effects on a wind turbine in complex terrain. As part of the WINSENT project a research test site comprising four meteorological masts and two research wind turbines is currently being constructed in the Swabian Alps in Southern Germany. This work is an essential part of the research of the Southern German wind energy research cluster WindForS. The terrain site is characterised by a densely forested escarpment and a flat plateau downstream of the slope. The met masts and wind turbines are built on this plateau. In the first part, high-resolution CFD simulations are performed to separately investigate the effects of the forested escarpment and of thermal stratification on the flow field and on the wind turbine accordingly. In the second part, all the examined effects are combined for a real-life case dated March 2021. There, unstable conditions prevailed and the forest shows low leaf area densities due to the wintertime. It is shown that atmospheric turbulence, forests, orographies, and thermal stratification must be considered when assessing the impact of wind turbines in complex terrain. All of these effects influence the flow field both at the turbine position as well as in its wake. Turbulent structures of the forest wake cross the rotor plane temporarily and thereby affect the turbine inflow. Moreover, convective conditions and upward flows caused by the orography have an impact on the performance output as inclined flows result in asymmetric torque distributions. The wind turbine wake and the forest wake mix further downstream, resulting in a fast decay of the turbine wake. The paper also describes how the turbulent flow in the wake changes in the presence of thermal stratification.
Recurrent convolutional neural network for object recognition (2015)

In recent years, the convolutional neural network (CNN) has achieved great success in many computer vision tasks. Partially inspired by neuroscience, CNN shares many properties with the visual system of the brain. A prominent difference is that CNN is typically a feed-forward architecture while in the visual system recurrent connections are abundant. Inspired by this fact, we propose a recurrent CNN (RCNN) for object recognition by incorporating recurrent connections into each convolutional layer. Though the input is static, the activities of RCNN units evolve over time so that the activity of each unit is modulated by the activities of its neighboring units. This property enhances the ability of the model to integrate the context information, which is important for object recognition. Like other recurrent neural networks, unfolding the RCNN through time can result in an arbitrarily deep network with a fixed number of parameters. Furthermore, the unfolded network has multiple paths, which can facilitate the learning process. The model is tested on four benchmark object recognition datasets: CIFAR-10, CIFAR-100, MNIST and SVHN. With fewer trainable parameters, RCNN outperforms the state-of-the-art models on all of these datasets. Increasing the number of parameters leads to even better performance. These results demonstrate the advantage of the recurrent structure over purely feed-forward structure for object recognition.
Novel (ovario) leukodystrophy related to AARS2 mutations (2014)

Mutations in AARS2 have been found in a severe form of infantile cardiomyopathy in 2 families. We present 6 patients with a new phenotype caused by AARS2 mutations, characterized by leukoencephalopathy and, in female patients, ovarian failure, indicating that the phenotypic spectrum associated with AARS2 variants is much wider than previously reported.
Use of oral ketamine in chronic pain management: A review (2009)

The analgesic effect of ketamine is primarily based on the antagonism of the N-methyl-d-aspartate (NMDA) receptor. Activation of NMDA receptors may play a crucial role in the pathogenesis of chronic pain. Little formal research has been performed on the efficacy and safety of ketamine in chronic pain, especially concerning long-term oral administration. This review provides an overview of the available clinical data on the use of oral ketamine in chronic pain management. A literature search was performed in MEDLINE, EMBASE and the Cochrane Library, resulting in 22 relevant articles. Because most retrieved articles were of a descriptive nature (e.g. case reports and case series) a quantitative analysis was not possible. There was no consistent dose-response relation. A recommended starting dosage in ketamine-naive patients is 0.5 mg/kg racemic ketamine or 0.25 mg/kg S-ketamine as a single oral dose. The dosage is increased by the same amount if required. For a continuous analgesic effect it is usually given 3-4 times daily. The injection fluid can be taken orally. When parenteral ketamine is switched to oral administration the daily dosage can be kept equal and, depending on clinical effect and/or adverse effects, is slowly increased. The pharmacologically active metabolite norketamine is believed to contribute to the analgesic effect of oral ketamine. Lack of evidence regarding efficacy, and the poor safety profile, do not support routine use of oral ketamine in chronic pain management. Oral ketamine may have a limited place as add-on therapy in complex chronic pain patients if other therapeutic options have failed.
The Use of High Frequency Percussive Ventilation (HFPV) in Postoperative Cardiac Surgery Patients Significantly Improves Gas Exchange without Impairment of Hemodynamics (2018)

Improvement in gas exchange, reflected in a significantly improved P/F ratio, wasn't accompanied by worsening in hemodynamic parameters. The significant gains in the P/F ratio were lost when patients were switched to conventional ventilation. This data suggest that HFPV provides significantly better gas exchange compared with CMV and can be safely utilized in postoperative cardiac patients without any significant effect on hemodynamics.
Eosinophil infiltration of human colonic carcinomas as a prognostic indicator. (1983)

In experiments with suspensions of cells from colonic carcinomas, we noted that some colonic carcinomas contain large numbers of eosinophils. We therefore carried out a prospective study with 67 almost consecutive colonic carcinomas in our medical center after optimal fixation and staining for the demonstration of eosinophils. Infiltration of the primary tumor by eosinophils was found to have marked prognostic significance. The proportion (4 of 17 or 23.5%) of carcinomas with more than 30 eosinophils/sq mm that had metastases was significantly less (p = 0.01) than the proportion (31 of 50 or 62.0%) of carcinomas with less than 30 eosinophils/sq mm that had metastases. At 18 months, following the resection of tumor in patients without metastases, all of the patients (9 of 9) with greater than 30 eosinophils/sq mm were alive in contrast to 73.7% (11 of 15) of the patients with less than 30 eosinophils/sq mm. The number of survivors at 18 months for the total population without regard to metastases was significantly greater (p = 0.028) for those with greater than 30 eosinophils/sq mm than for those with less than 30 eosinophils/sq mm. We conclude that the quantitative assessment of eosinophils is one of the most important aspects of the microscopic evaluation of this common human tumor.
Stability of radiomics features in apparent diffusion coefficient maps from a multi-centre test-retest trial (2019)

Quantitative radiomics features, extracted from medical images, characterize tumour-phenotypes and have been shown to provide prognostic value in predicting clinical outcomes. Stability of radiomics features extracted from apparent diffusion coefficient (ADC)-maps is essential for reliable correlation with the underlying pathology and its clinical applications. Within a multicentre, multi-vendor trial we established a method to analyse radiomics features from ADC-maps of ovarian (n = 12), lung (n = 19), and colorectal liver metastasis (n = 30) cancer patients who underwent repeated (<7 days) diffusion-weighted imaging at 1.5 T and 3 T. From these ADC-maps, 1322 features describing tumour shape, texture and intensity were retrospectively extracted and stable features were selected using the concordance correlation coefficient (CCC > 0.85). Although some features were tissue- and/or respiratory motion-specific, 122 features were stable for all tumour-entities. A large proportion of features were stable across different vendors and field strengths. By extracting stable phenotypic features, fitting-dimensionality is reduced and reliable prognostic models can be created, paving the way for clinical implementation of ADC-based radiomics.
ChemInform Abstract: Coordination Chemistry of Group 13 Monohalides (2011)

Abstract Review: 135 refs.
Utilisation de modèles pré-cliniques murins orthotopiques et transgéniques pour l'évaluation d'approches immunothérapeutiques dans le traitement du cancer (2014)

Dans l’approche experimentale de l’immunotherapie des tumeurs solides, les modeles murins sont utilises pour des raisons de rapidite et de reproductibilite. Le plus souvent, les modeles tumoraux murins sont ectopiques ce qui constitue un modele artificiel qui ne reflete qu’une partie de la realite biologique de tumeurs provenant de diverses origines.Mon projet de these a consiste a mettre au point de nouveaux modeles pre-cliniques murins permettant de mieux mimer les situations pathologiques des tumeurs solides chez l’homme. Pour cela, je me suis notamment interessee a un modele orthotopique de cancer du rein (implantation de cellules RenCa ou RenCa-MUC1 dans la capsule renale) et a un modele spontane de cancer du sein (souris MMTV-PyMT). Ces modeles ont ensuite permis l’evaluation de trois differentes approches d’immunotherapie a savoir la therapie virale oncolytique, la vectorisation d’antigenes tumoraux au moyen d’un vecteur viral ainsi que la therapie via un anticorps monoclonal.
Ultrasensitive detection of DNA by the PCR-Induced generation of DNAzymes: The DNAzyme primer approach (2006)

The ultrasensitive detection of DNA is achieved by PCR-induced evolution of a DNAzyme.
In situ Formation of Polystyrene in Adsorbed Surfactant Bilayers on Precipitated Silica (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIn situ Formation of Polystyrene in Adsorbed Surfactant Bilayers on Precipitated SilicaJohn H. O'Haver, Jeffrey H. Harwell, Edgar A. O'Rear, Linda J. Snodgrass, and Walter H. WaddellCite this: Langmuir 1994, 10, 8, 2588–2593Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/la00020a017https://doi.org/10.1021/la00020a017research-articleACS PublicationsRequest reuse permissionsArticle Views367Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Polymerization in Coordination Nanospaces (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Loss Analysis for Combined Wind and Surge in Hurricanes (2011)

Residential buildings in coastal areas are often at risk to hurricanes, which can result in both wind and surge damage. In the United States, economic losses average approximately $US5.4 billion annually from hurricanes, and more than 75% of declared federal disasters are a result of flooding. Although current design codes do consider load combinations, these are generally for nonenvironmental (natural hazard) loading and focus on dead and live loads; their combination with each environmental load is considered individually. This paper presents correlations between hurricane winds and wind-induced surge from a flood standpoint to estimate the loss to residential construction from combined wind and surge using assembly-based vulnerability. The method presented for estimating loss from combined wind and surge in hurricanes may be used for design code assessment and calibration, retrofit planning for buildings in coastal areas, disaster-planning purposes, and potentially insurance underwriting.
Automatic fish sounds classification (2018)

The work presented in this paper focuses on the use of acoustic systems for passive acoustic monitoring of ocean vitality for fish populations. Specifically, it focuses on the use of acoustic systems for passive acoustic monitoring of ocean vitality for fish populations. To this end, various indicators can be used to monitor marine areas such as both the geographical and temporal evolution of fish populations. A discriminative model is built using supervised machine learning (random-forest and support-vector machines). Each acquisition is represented in a feature space, in which the patterns belonging to different semantic classes are as separable as possible. The set of features proposed for describing the acquisitions come from an extensive state of the art in various domains in which classification of acoustic signals is performed, including speech, music, and environmental acoustics. Furthermore, this study proposes to extract features from three representations of the data (time, frequency, and cepstral domains). The proposed classification scheme is tested on real fish sounds recorded on several areas, and achieves 96.9% correct classification compared to 72.5% when using reference state of the art features as descriptors. The classification scheme is also validated on continuous underwater recordings, thereby illustrating that it can be used to both detect and classify fish sounds in operational scenarios.
Voltage-Induced Material Removal for Electrochemical Mechanical Planarization of Copper in Electrolytes Containing NO[sub 3][sup −], Glycine, and H[sub 2]O[sub 2] (2005)

The main utility of electrochemical mechanical planarization (ECMP) is its low-pressure planarization capability, which is necessary for processing the new interconnect structures that contain mechanically fragile porous low permittivity dielectrics. Controlling the surface reactions (that is, controlling the voltage-induced material removal) in ECMP, however, requires a carefully designed combination of a number of electrochemical input variables (voltage activation program and electrolyte composition). In the present work, we study the main experimental factors for designing these parameters and present results for rectangular-voltage-pulse modulated dissolution of Cu in electrolytes containing , glycine, and hydrogen peroxide.
Empirical analysis of the impact of collaborative care in internal medicine: Applications to length of stay, readmissions, and discharge planning (2023)

This paper presents original insights about the benefits of collaborative care in an internal medicine inpatient service at a Texas academic medical center. Collaborative care requires close and frequent coordination among all members of a patient care team - providers, case managers, social workers, specialists, and other clinical and professional staff. Hospitals and clinicians are concerned with whether the benefits accrued to patients and hospital operations outweigh the resource requirements imposed by this innovative integrated care approach. To investigate outcomes, the approach was implemented by one of its five teaching teams at the medical center hospital. Researchers then developed statistical models that suggested the effect of collaborative care on patient length of stay and discharge planning was favorable and statistically significant. Lasso and stepwise regression models were estimated that suggested a 9% decrease in expected length of stay –without increased readmissions – and an increased likelihood of being discharged before 2 pm to enable improved patient throughput and bed turnover. Additional patient survey data confirmed that patient satisfaction remained high for patients under the care of the collaborative care team. Discussions with hospitalists and nurses during and after implementation indicated that the new approach required a change in logistics and how patient care was performed. Our research suggests there is a corresponding ‘learning effect’ – the impact was more pronounced and significant once an attending physician had two or more separate rotations on the collaborative care team.
Level of Human Growth Hormone (hGH) in Urine Determined by A Highly Specific and Sensitive Sandwich Enzyme Immunoassay (1986)

Abstract Levels of human growth hormone (hGH) in urine samples were determined by a highly specific and sensitive sandwich enzyme immunoassay, which had little cross-reaction with human luteinizing hormone, human follicle-stimulating hormone, human thyroid-stimulating hormone and human prolactin. The volume of urine samples used was 0.05 ml. Urine hGH levels in normal subjects, aged less than 2 yr, 2-5 yr, 6-15 yr and 28-35 yr (male) were 78-113, 19-51, 7.8-25 and 1.1-5.2 ng/g of creatinine, respectively. In dwarfism patients aged 6-15 yr, urine hGH levels were < 0.2-6.0 ng/g of creatinine.
Pharmacokinetics of clarithromycin in Helicobacter pylori eradication therapy in patients with liver cirrhosis (2000)

The 2-week low-dose lansoprazole-based triple therapy tested is a simple, effective and well-tolerated regimen for H. pylori eradication in patients with liver cirrhosis.
Caputo-Type Modification of the Erdélyi-Kober Fractional Derivative (2007)

The Caputo fractional derivative is one of the most used definitions of a fractional derivative along with the Riemann-Liouville and the Grünwald-Letnikov ones. Whereas the Riemann-Liouville definition of a fractional derivative is usually employed in mathematical texts and not so frequently in applications, and the Grünwald-Letnikov definition – for numerical ap-proximation of both Caputo and Riemann-Liouville fractional derivatives, the Caputo approach appears often while modeling applied problems by means of fractional derivatives and fractional order differential equations. In the mathematical texts and applications, the so called Erdélyi-Kober (E-K) fractional derivative, as a generalization of the Riemann-Liouville fractional derivative, is often used, too. In this paper, we investigate some properties of the Caputo-type modification of the Erdélyi-Kober fractional derivative. The relation between the Caputo-type modification of the E-K fractional derivative and the classical E-K fractional derivative is the same as the relation between the Caputo fractional derivative and the Riemann-Liouville fractional derivative, i.e. the operations of integration and dif-ferentiation are interchanged in the corresponding definitions. Here, some new properties of the classical Erdélyi-Kober fractional derivative and the respective ones of its Caputo-type modification are presented together.