gebhart/patrepeval huggingface dataset:
Influence of Topography on Endothelialization of Stents: Clues for New Designs (2000)

To evaluate the influence of stent design on endothelialization of the stented surface, we placed trapezoidal objects of variable thickness on a confluent culture of endothelial cells and subjected the assembly to flow and shear conditions similar to those found in arteries. After 24 h, we measured and analyzed the area on top of the objects covered by cells and the maximum migration distance from the borders. In addition, we evaluated areas devoid of cells surrounding the objects, which developed after exposure of the assembly to flow. The cell-covered area and migration distance significantly decreased on objects 75 microns thick, and it was nonexistent on objects 250 microns thick. Areas devoid of cells or gaps were largest adjacent to the downflow side of the object, disposed transversely to flow. Cell gaps were smallest along the side aligned with flow. In conclusion, endothelial cell coverage may be impaired by stent wall thickness larger than 75 microns. It is likely that this impairment is related to flow disturbances impairing cell attachment.
Discovering High Utility Episodes in Sequences (2019)

Sequence data, e.g., complex event sequence, is more commonly seen than other types of data (e.g., transaction data) in real-world applications. For the mining task from sequence data, several problems have been formulated, such as sequential pattern mining, episode mining, and sequential rule mining. As one of the fundamental problems, episode mining has often been studied. The common wisdom is that discovering frequent episodes is not useful enough. In this paper, we propose an efficient utility mining approach namely UMEpi: Utility Mining of high-utility Episodes from complex event sequence. We propose the concept of remaining utility of episode, and achieve a tighter upper bound, namely episode-weighted utilization (EWU), which will provide better pruning. Thus, the optimized EWU-based pruning strategies can achieve better improvements in mining efficiency. The search space of UMEpi w.r.t. a prefix-based lexicographic sequence tree is spanned and determined recursively for mining high-utility episodes, by prefix-spanning in a depth-first way. Finally, extensive experiments on four real-life datasets demonstrate that UMEpi can discover the complete high-utility episodes from complex event sequence, while the state-of-the-art algorithms fail to return the correct results. Furthermore, the improved variants of UMEpi significantly outperform the baseline in terms of execution time, memory consumption, and scalability.
Controlling Cells with Light and LOV (2018)

Abstract Optogenetics is a powerful method for studying dynamic processes in living cells and has advanced cell biology research over the recent past. Key to the successful application of optogenetics is the careful design of the light‐sensing module, typically employing a natural or engineered photoreceptor that links the exogenous light input to the cellular process under investigation. Light–oxygen–voltage (LOV) domains, a highly diverse class of small blue light sensors, have proven to be particularly versatile for engineering optogenetic input modules. These can function via diverse modalities, including inducible allostery, protein recruitment, dimerization, or dissociation. This study reviews recent advances in the development of LOV domain‐based optogenetic tools and their application for studying and controlling selected cellular functions. Focusing on the widely employed LOV2 domain from Avena sativa phototropin‐1, this review highlights the broad spectrum of engineering opportunities that can be explored to achieve customized optogenetic regulation. Finally, major bottlenecks in the development of optogenetic methods are discussed and strategies to overcome these with recent synthetic biology approaches are pointed out.
Manual Compared With Electric Vacuum Aspiration for Treatment of Molar Pregnancy (2018)

Manual vacuum aspiration appears to be similar to electric vacuum aspiration for treatment of molar pregnancy and may be associated with less development of uterine synechia.
Onset of efficacy with acute long-acting injectable paliperidone palmitate treatment in markedly to severely ill patients with schizophrenia: post hoc analysis of a randomized, double-blind clinical trial (2011)

In this markedly to severely ill population, acute treatment with 234 mg PP improved psychotic symptoms compared with placebo by day 4. After subsequent injections, observed improvements are suggestive of a dose-dependent effect. No unexpected tolerability findings were noted.
Acoustics of Fluid-Saturated Porous Media (1982)

The class of porous materials studied in this paper are those described as two component composites where both the fluid phase and the solid phase are continuous and interpenetrating. The bulk acoustic propagation in these materials has been shown both theoretically and experimentally to include two types of compressional waves. The fast or normal compressional wave corresponds to an in-phase motion of the fluid and the solid while the slow compressional wave corresponds to and out-of-phase motion. In this paper, a review of the theoretical and experimental work is presented with emphasis on the conditions necessary to observe the two compressional wave behavior in real materials.
Former les futur.e.s ingénieur.e.s aux questions d'égalité femmes-hommes avec des ateliers d'écriture créative (2018)

International audience
Perspective on optical imaging for functional assessment in musculoskeletal extremity trauma surgery (2020)

While there are several optical measurements to directly measure bone function, the choice of tools can determine also the signal strength and depth of sampling. For orthopaedic surgery, real-time data regarding bone and tissue perfusion should lead to more effective patient-specific management of common orthopaedic conditions, requiring deeper penetrance commonly seen with indocyanine green imaging. This will lower morbidity and result in decreased variability associated with how these conditions are managed.
Memory disambiguation to facilitate instruction-level parallelism compilation (1995)

... to support low-level optimization and scheduling. A dynamic approach, the memory conflict buffer, originally proposed by Chen [1], is analyzed across a large suite of integer and floating-point benchmarks. A new static approach, termed sync arcs, involving the passing of explicit dependence arcs from the source-level code down to the low-level code, is proposed and evaluated. This investigation of both dynamic and static memory disambiguation allows a quantitative analysis of the tradeoffs between the two approaches.
Hardware and software support for speculative execution of sequential binaries on a chip-multiprocessor (1998)

Article Hardware and software support for speculative execution of sequential binaries on a chip-multiprocessor Share on Authors: Venkata Krishnan Department of Computer Science, University of Illinois at Urbana-Champaign, IL Department of Computer Science, University of Illinois at Urbana-Champaign, ILView Profile , Josep Torrellas Department of Computer Science, University of Illinois at Urbana-Champaign, IL Department of Computer Science, University of Illinois at Urbana-Champaign, ILView Profile Authors Info & Claims ICS '98: Proceedings of the 12th international conference on SupercomputingJuly 1998 Pages 85–92https://doi.org/10.1145/277830.277852Online:13 July 1998Publication History 50citation495DownloadsMetricsTotal Citations50Total Downloads495Last 12 Months6Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Stable isotope analysis reveals ontogenetic feeding shifts in Pacific blue marlin (Makaira nigricans) off eastern Taiwan (2019)

To gain a better understanding of the trophic ecology of Pacific blue marlin Makaira nigricans off eastern Taiwan, nitrogen and carbon stable isotopes (δ<sup>15</sup> N and δ<sup>13</sup> C) and Bayesian mixing models were used to explore trophic dynamics and potential ontogenetic feeding shifts across M. nigricans of different size classes. Makaira nigricans samples from east of Taiwan (n = 213) and Palau (n = 37), as well as their prey (n = 70), were collected during 2012 and 2013. Results indicated increases in δ<sup>15</sup> N with size, with values of larger size classes (> 200 cm eye-to-fork length; L<sub>EF</sub> ) significantly higher than those < 200 cm L<sub>EF</sub> . Values of δ<sup>13</sup> C were negatively correlated with size. Makaira nigricans > 200 cm L<sub>EF</sub> had the highest estimated trophic position (4.44) and also exhibited ontogenetic changes in trophic position. Large M. nigricans fed more on dolphinfish Coryphaena hippurus and hairtail Trichiurus lepturus, while smaller M. nigricans consumed smaller forage fish (e.g., moonfish Mene maculata) and cephalopods. These changes may relate to greater swimming speeds and vertical habitat use in larger M. nigricans, allowing capture and consumption of larger prey items at higher trophic positions. The high trophic level of M. nigricans east of Taiwan confirms its important role as an apex predator in marine food webs and how ecological role changes with size.
Total Synthesis of 10-Isothiocyanatoguaia-6-ene (1994)

Abstract Total synthesis of a unique isothiocyano sesquiterpene, 10-isothiocyanatoguaia-6-ene, was achieved utilizing the oxidative radical cyclization reaction of a bicyclo[4.1.0]heptanol derivative with Mn(pic)3 as the key step.
Figure S2. Downregulation of MHC class I on CD11b+Gr-1+ cells from anti-PD-1 resistant tumors. from Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy (2023)

&lt;p&gt;This figure shows that CD11b+Gr-1+ cells from anti-PD-1 resistant tumors also show downregulation of MHC class I molecules&lt;/p&gt;
An area-efficient, 0.022-mm2, fully integrated resistor-less relaxation oscillator for ultra-low power real-time clock applications (2017)

In this paper, we propose a fully integrated and area-efficient resistor-less relaxation oscillator (ROSC) for ultra-low power real-time clock (RTC) applications. The proposed ROSC is based on a conventional ROSC and modified to be area-efficient circuit configuration, without using resistors. The proposed ROSC consists of a bias current source, proportional to absolute temperature (PTAT) voltage source, current mode ROSC, shunt regulator, and output logic circuit. The PTAT voltage source and shut regulator are used to compensate for the temperature characteristics of the ROSC. By implementing our proposed ROSC in a 65-nm CMOS process, the area was 0.022 mm2. Simulated results demonstrated that our proposed ROSC generates 32.5-kHz clock frequency and achieves ultra-low power dissipation of 271 nW. The temperature and voltage dependences of the oscillation frequency were 138ppm/°C and 13.9ppm/mV, respectively. Monte Carlo statistical simulations showed that the mean, standard deviation, and the coefficient of variation are 32.3 kHz, 0.6 kHz, and 1.9%, respectively.
REVIEWS OF MUSIC (1966)

REVIEWS OF MUSIC Get access Blow John, Six Suites, ed. by Howard Ferguson. ( Stainer & Bell, London, 1965, 12s. 6d.) Intabolatura nova di balli {Venice, 1551), ed. by William Oxenbury & Thurston Dart. ( Stainer & Bell, London, 1965, 10s. 6d.) J. D. J. D. Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume 47, Issue 3, July 1966, Pages 283–284, https://doi.org/10.1093/ml/47.3.283 Published: 01 July 1966
Endovascular Perfusion Augmentation for Critical Care: Partial Aortic Occlusion for Treatment of Severe Ischemia–Reperfusion Shock (2018)

Using a swine model of severe shock, the addition of EPACC to SCC significantly reduced fluid resuscitation requirements and improved blood pressure. This is the first description of a new therapy for patients in refractory shock or in resource-limited settings.
49. LA RUTA CRISTERA: VALORACIÓN DE UN PRODUCTO TURÍSTICO RELIGIOSO (2014)

Universidad complutense de Madrid
Facultad de Geografia e Historia
Consejo Espanol de Estudios Iberoamericanos
Asociacion de Geografos Espanoles de America Latina
Asociacion de Geografos Espanoles
Centro de Ciencias Humanas y Sociales
Centro de Estudios Territoriales Ibero Americanos
Instituto Complutense de Estudios Internacionales
Universidad de Extremadura
Parque Nacional de Monfrague
Monolithic FFF-Printed, Biocompatible, Biodegradable, Dielectric-Conductive Microsystems (2017)

We report additively manufactured biodegradable microsystems composed of dielectric and electrically conductive layers. The devices were made via fused filament fabrication (FFF), which is arguably the simplest and cheapest commercial 3-D printing technology, done with the most inexpensive printing hardware. The base constitutive material is polylactic acid (PLA)-a biodegradable polymer made of cornstarch that can be doped with micro and nanoparticles to change its physical properties, e.g., become electrically conductive. The devices were monolithically manufactured using a commercial dual extruder 3-D-printer. The feature resolution and surface topography of the printing technology was characterized for both dielectric and conductive materials; their outgassing rates were measured and their cytotoxicity was investigated. The gauge factor of the conductive PLA was measured. Basic electrical components, cantilevers, and electrohydrodynamic liquid ionizers with integrated extractor electrode and threaded microfluidic port were demonstrated.
PTS-Mediated Regulation of the Transcription Activator MtlR from Different Species: Surprising Differences despite Strong Sequence Conservation (2015)

The hexitol D-mannitol is transported by many bacteria via a phosphoenolpyruvate (PEP):carbohydrate phosphotransferase system (PTS). In most Firmicutes, the transcription activator MtlR controls the expression of the genes encoding the D-mannitol-specific PTS components and D-mannitol-1-P dehydrogenase. MtlR contains an N-terminal helix-turn-helix motif followed by an Mga-like domain, two PTS regulation domains (PRDs), an EIIB(Gat)- and an EIIA(Mtl)-like domain. The four regulatory domains are the target of phosphorylation by PTS components. Despite strong sequence conservation, the mechanisms controlling the activity of MtlR from Lactobacillus casei, Bacillus subtilis and Geobacillus stearothermophilus are quite different. Owing to the presence of a tyrosine in place of the second conserved histidine (His) in PRD2, L. casei MtlR is not phosphorylated by Enzyme I (EI) and HPr. When the corresponding His in PRD2 of MtlR from B. subtilis and G. stearothermophilus was replaced with alanine, the transcription regulator was no longer phosphorylated and remained inactive. Surprisingly, L. casei MtlR functions without phosphorylation in PRD2 because in a ptsI (EI) mutant MtlR is constitutively active. EI inactivation prevents not only phosphorylation of HPr, but also of the PTS(Mtl) components, which inactivate MtlR by phosphorylating its EIIB(Gat)- or EIIA(Mtl)-like domain. This explains the constitutive phenotype of the ptsI mutant. The absence of EIIB(Mtl)-mediated phosphorylation leads to induction of the L. caseimtl operon. This mechanism resembles mtlARFD induction in G. stearothermophilus, but differs from EIIA(Mtl)-mediated induction in B. subtilis. In contrast to B. subtilis MtlR, L. casei MtlR activation does not require sequestration to the membrane via the unphosphorylated EIIB(Mtl) domain.
Learner-Controlled Computing: A Description and Rationale (1975)

This paper discusses a use of technology in which the student controls the computer (e.g., computer programming) instead of it controlling the student (e.g., drill-and-practice). A description of the nature of this mode of computer use is provided, and some examples are given. A rationale for learner control is discussed in terms of cognitive and affective outcomes of computing. The cognitive outcomes include relatively specific learning and thinking skills and more general systematic methods of problem solving. Affective outcomes include self-confidence, curiosity and exploratory behaviors, and motivation.
Electrocatalysis of 2,6-Dinitrophenol Based on Wet-Chemically Synthesized PbO-ZnO Microstructures (2022)

In this approach, a reliable 2,6-dinitrophenol (2,6-DNP) sensor probe was developed by applying differential pulse voltammetry (DPV) using a glassy carbon electrode (GCE) decorated with a wet-chemically prepared PbO-doped ZnO microstructures’ (MSs) electro-catalyst. The nanomaterial characterizing tools such as FESEM, XPS, XRD, UV-vis., and FTIR were used for the synthesized PbO-doped ZnO MSs to evaluate in detail of their optical, structural, morphological, functional, and elemental properties. The peak currents obtained in DPV analysis of 2,6-DNP using PbO-doped ZnO MSs/GCE were plotted against the applied potential to result the calibration of 2,6-DNP sensor expressed by ip(µA) = 1.0171C(µM) + 22.312 (R2 = 0.9951; regression co-efficient). The sensitivity of the proposed 2,6-DNP sensor probe obtained from the slope of the calibration curve as well as dynamic range for 2,6-DNP detection were found as 32.1867 µAµM−1cm−2 and 3.23~16.67 µM, respectively. Besides this, the lower limit of 2,6-DNP detection was calculated by using signal/noise (S/N = 3) ratio and found as good lowest limit (2.95 ± 0.15 µM). As known from the perspective of environment and healthcare sectors, the existence of phenol and their derivatives are significantly carcinogenic and harmful which released from various industrial sources. Therefore, it is urgently required to detect by electrochemical method with doped nanostructure materials. The reproducibility as well as stability of the working electrode duration, response-time, and the analysis of real environmental-samples by applying the recovery method were measured, and found outstanding results in this investigation. A new electrochemical research approach is familiarized to the development of chemical sensor probe by using nanostructured materials as an electron sensing substrate for the environmental safety (ecological system).
GM‐CSF in the treatment of Felty syndrome (1991)

Abstract Many therapeutic agents have been tried with variable success in the treatment of Felty neutropenia, but the reports are anecdotal. We now describe the second trial of recombinant granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), in a splenectomized, infected patient with Felty syndrome.
Automated scoring of the Rey-Osterrieth Complex Figure Test using a deep-learning algorithm (2019)

Abstract Objective To validate a fully automated scoring algorithm for the Rey-Osterrieth Complex Figure Test (ROCFT) by comparing the scoring results of the algorithm to the results of human raters. Method The algorithm consisted of a cascade of deep neural networks which were trained on human rater scores to extract the 18 segments of the figure, and to quantify the patient’s performance. Algorithm results were compared to six expert raters for 303 drawings. We tested whether the average correlation between algorithm scores and scores by all human raters was equivalent to the average inter-rater correlation (with equality bound Δr &lt; .05). The immediate and delayed recall trial were used; the copy trial showed a strong ceiling effect. Results The mean Pearson correlation between raters was .94 (SD = 0.01). The correlation between to algorithm and the raters was .88 (SD = 0.02). A two-one-sided t-tests (TOST) equivalence test showed that these correlations were not strictly equivalent, t(5) = 4.02, p = .995, 95% CI [0.35, 0.52]. Conclusions Although not strictly equivalent to human ratings, the algorithm’s performance is high, approaching a level of reliability found among human raters. We expect that improved individual segment detection will bring the algorithm scoring accuracy on par with that of human raters. Algorithmic scoring of the ROCFT will likely save valuable time and lead to higher levels of standardization in clinical practice.
Application of Linear-Frequency-Modulated Continuous-Wave (LFMCW) Radars for Tracking of Vital Signs (2014)

This paper focuses on the exploitation of linear-frequency-modulated continuous-wave (LFMCW) radars for noncontact range tracking of vital signs, e.g., respiration. Such short-range system combines hardware simplicity and tracking precision, thus outperforming other remote-sensing approaches in the addressed biomedical scenario. A rigorous mathematical analysis of the operating principle of the LFMCW radar in the context of vital-sign monitoring, which includes the explanation of key aspects for the maintenance of coherence, is detailed. A precise phase-based range-tracking algorithm is also presented. Exhaustive simulations are carried out to confirm the suitability and robustness against clutter, noise, and multiple scatterers of the proposed radar architecture, which is subsequently implemented at the prototype level. Moreover, live data from real experiments associated to a metal plate and breathing subjects are obtained and studied.
Compressed-domain Video Processing (2003)

compressed domain processing, transcoding, video editing, MPEG, splicing, reverse play, frame rate conversion, interlace to progressive, motion vector resampling Video compression algorithms are being used to compress digital video for a wide variety of applications, including video delivery over the Internet, advanced television broadcasting, video streaming, video conferencing, and video storage and editing. The impressive performance of modern compression algorithms, combined with the growing availability of video encoders and decoders and low-cost computers, storage devices, and networking equipment, makes it evident that between video capture and video playback, video will be handled in compressed video form. The resulting end-toend compressed digital video systems motivate the need to develop efficient algorithms for handling compressed digital video.
Sigma-Delta Pulse Width Modulator: Jitter Analysis (2018)

High accuracy pulse width modulation (PWM) is crucial for saturating devices such as optical communication systems, control and energy efficient amplification. In this paper we propose a closed-loop PWM architecture, called Sigma-Delta (ΣΔ) PWM, showing jitter robustness and compensation for some PWM inaccuracies arising from clock imprecision. The ΣΔ-PWM architecture trades oversampling and some increases in architectural complexity to gain in signal quality, leveraging on the noise shaping capability of the ΣΔ loop. Analytical results as well as numerical simulations assess the impact of timing jitter as key parameter in PW modulators.