gebhart/patrepeval huggingface dataset:
In vivo Role of NAD(P)H:Quinone Oxidoreductase 1 in Metabolic Activation of Mitomycin C and Bone Marrow Cytotoxicity (2007)

NAD(P)H:quinone oxidoreductase 1(-/-) (NQO1(-/-)), NQO1(+/-) along with NRH:quinone oxidoreductase 2(-/-) (NQO2(-/-)), and wild-type (WT) mice were exposed to five once weekly doses of mitomycin C. The mice were euthanized 15 weeks after the first dose. Blood cell counts and histologic analyses were done. WT and NQO2(-/-) mice showed hypocellularity and a significant increase in adipocytes in bone marrow. They also showed anemia because of the loss of RBC and hemoglobin. The neutrophils and platelets were reduced, whereas other blood cell types and tissues were normal. Interestingly, NQO1(-/-) mice showed a complete resistance to mitomycin C-induced bone marrow cytotoxicity and reduction in RBC, hemoglobin, and neutrophils. NQO1(+/-) mice also showed limited resistance to mitomycin C-induced bone marrow cytotoxicity. These data show a major in vivo role of NQO1 in metabolic activation of mitomycin C with implications in mitomycin C chemotherapy.
MODELING OF IMMERSION ULTRASONIC TESTING AND SIMULATION OF SCATTERED WAVES BY FLAWS (2006)

This paper proposes a mathematical model based on a linear time-shift invariant (LTI) system for nondestructive ultrasonic testing (UT). We consider here an entire model of the immersion UT including ultrasonic wave generation in water, transmission from water to solid and vice versa, and scattering by flaws in the solid. A multi-Gaussian beam model is introduced to express wave propagation in both transmission and reception processes. The scattering process is calculated by means of boundary element method. These processes are expressed by frequency dependent modules in the LTI system, and the total output signal is obtained as a product of the modules. The performance of this model is shown by numerical simulations of flaw-echoes from internal and surface-breaking cracks.
Specification and Simulation of Synthetic Multicelled Behaviors (2012)

Recent advances in the design and construction of synthetic multicelled systems in E. coli and S. cerevisiae suggest that it may be possible to implement sophisticated distributed algorithms with these relatively simple organisms. However, existing design frameworks for synthetic biology do not account for the unique morphologies of growing microcolonies, the interaction of gene circuits with the spatial diffusion of molecular signals, or the relationship between multicelled systems and parallel algorithms. Here, we introduce a framework for the specification and simulation of multicelled behaviors that combines a simple simulation of microcolony growth and molecular signaling with a new specification language called gro. The framework allows the researcher to explore the collective behaviors induced by high level descriptions of individual cell behaviors. We describe example specifications of previously published systems and introduce two novel specifications: microcolony edge detection and programmed microcolony morphogenesis. Finally, we illustrate through example how specifications written in gro can be refined to include increasing levels of detail about their bimolecular implementations.
The synthesis of khusimone (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleThe synthesis of khusimoneGeorge Buechi, Arnold Hauser, and Josef LimacherCite this: J. Org. Chem. 1977, 42, 20, 3323–3324Publication Date (Print):September 1, 1977Publication History Published online1 May 2002Published inissue 1 September 1977https://pubs.acs.org/doi/10.1021/jo00440a036https://doi.org/10.1021/jo00440a036research-articleACS PublicationsRequest reuse permissionsArticle Views283Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Figure 4 from Functional Genetic Screens Identify Genes Essential for Tumor Cell Survival in Head and Neck and Lung Cancer (2023)

&lt;p&gt;PDF file - 75K, Deconvolution of AURKB and AURKC siRNA pools in multiple tumor cell lines and the effect of simultaneous knockdown of the aurora kinase genes on cell viability.&lt;/p&gt;
A Wideband Balanced-to-Unbalanced Coupled-Line Power Divider (2016)

A compact wideband balanced-to-unbalanced (BTU) out-of-phase power divider (PD) is proposed in this letter. This novel circuit essentially consists of three pairs of cascaded coupled lines and a grounded resistor for output isolation. By using the even- (odd-) mode method analysis and the traditional transmission-line theory, closed-form design equations for equal power division with out of phase from one differential input to two unbalanced outputs, high output isolation and good common-mode suppression are obtained, simultaneously. In addition, an experimental PD is designed and fabricated. The good performance and the consistency between the simulated and measured results verify our design theory.
Targeting the Blood–Brain Tumor Barrier with Tumor Necrosis Factor-α (2022)

The blood-brain tumor barrier represents a major obstacle for anticancer drug delivery to brain tumors. Thus, novel strategies aimed at targeting and breaching this structure are of great experimental and clinical interest. This review is primarily focused on the development and use of a derivative of tumor necrosis factor-α (TNF) that can target and alter the blood-brain-tumor-barrier. This drug, called NGR-TNF, consists of a TNF molecule fused to the Cys-Asn-Gly-Arg-Cys-Gly (CNGRCG) peptide (called NGR), a ligand of aminopeptidase N (CD13)-positive tumor blood vessels. Results of preclinical studies suggest that this peptide-cytokine fusion product represents a valuable strategy for delivering TNF to tumor vessels in an amount sufficient to break the biological barriers that restrict drug penetration in cancer lesions. Moreover, clinical studies performed in patients with primary central nervous system lymphoma, have shown that an extremely low dose of NGR-TNF (0.8 µg/m<sup>2</sup>) is sufficient to promote selective blood-brain-tumor-barrier alteration, increase the efficacy of R-CHOP (a chemo-immunotherapy regimen) and improve patient survival. Besides reviewing these findings, we discuss the potential problems related to the instability and molecular heterogeneity of NGR-TNF and review the various approaches so far developed to obtain more robust and homogeneous TNF derivatives, as well as the pharmacological properties of other peptide/antibody-TNF fusion products, muteins and nanoparticles that are potentially useful for targeting the blood-brain tumor barrier. Compared to other TNF-related drugs, the administration of extremely low-doses of NGR-TNF or its derivatives appear as promising non-immunogenic approaches to overcome TNF counter-regulatory mechanism and systemic toxicity, thereby enabling safe breaking of the BBTB.
Hypothenar Hammer Syndrome in a Computer Programmer: CTA Diagnosis and Surgical and Endovascular Treatment (2009)

Finger ischemia due to embolic occlusion of digital arteries resulting from trauma to the palmar ulnar artery has been termed hypothenar hammer syndrome (HHS). In HHS, arterial thrombosis and/or aneurysm formation with embolization to the digital arteries causes symptoms of ischemia. We describe a patient in whom the initial diagnosis was made on multidetector computed tomographic angiography (CTA), as well as his endovascular and surgical management.
DESIGN OF A LONG-ACTING RECOMBINANT FSH (2007)

The glycoprotein hormone family consists of the pituitary proteins lutropin (LH), follitropin (FSH), thyrotropin (TSH), and the human placental hormone chorionic gonadotropin (CG). They are heterodimers, which share a common α subunit but differ in their hormone-specific β subunits. All of the subunits are glycosylated, containing asparagine-linked oligosaccharides and, in the case of the CGβ subunit, O-linked carbohydrates are also present in a discrete region at the carboxyl end (termed carboxyl terminal peptide or CTP). The complexity of the gonadotropin structure has been a reservoir of numerous fascinating structure-function investigations. The use of recombinant DNA mutagenesis and transfection protocols not only has elucidated new biological findings regarding the glycoprotein hormones, but has led to the design of therapeutic agents. For example, the CTP of the CGβ subunit is essential for the relatively long half-life of hCG in the circulation. Currently, a major issue regarding the clinical use of FSH to induce follicle development in Assisted Reproduction Protocols is its short half-life in vivo, which necessitates multiple injections. Using recombinant DNA techniques, the CTP of the hCGβ was fused to the human FSHβ subunit coding sequence, thereby generating an FSH agonist that exhibited a prolonged circulating half-life and enhanced bioactivity in vivo. Treatment with such long-acting gonadotropins would be less stressful for the patient, requiring fewer injections. Recent clinical trials have demonstrated the expected clinical efficacy of this novel analog. Such a therapeutic agent represents a powerful example of how examining the biology of these hormones can lead to a generation of agonists to aid the clinician and patient in the more comfortable and efficient treatment of reproductive disorders.
Towards an integrated probabilistic analysis of the blackout risk in transmission power systems (2011)

In our modern society, the electrical grid has become one of the most critical infrastructures. Even if feedback from the electrical sector is very positive, electricity generation and transmission cannot be considered as totally reliable activities. A residual blackout risk remains, especially as new ways of generating electricity and operating the grid develop. To study the grid reliability, deterministic criteria are usually considered. Probabilistic risk assessment methods have also been developed, but they usually neglect the dependencies between failures and the dynamic evolution of the grid in the course of a transient: yet a blackout is due to cascading failures in the grid. There is a strong coupling between events, since the loss of an element increases the stress on others and, hence, their probability to fail. Our purpose is therefore to develop an integrated probabilistic approach to blackout analysis, capable of handling the dynamic response of the grid to stochastic initiating perturbations and the event sequences they possibly entail. This approach is adapted from dynamic reliability methodologies, by accounting for the different characteristic times and processes of different cascading phases leading to a blackout. This paper focuses on the modeling adopted for the first phase, ruled by thermal transients. The goal is to identify dangerous cascading scenarios (possibly leading to a blackout) and calculate their frequency. A Monte Carlo code derived from this methodology is validated on a test grid. Some dangerous scenarios are presented and their frequency calculated by this method is compared with the classical estimation.
Portable perfusion phantom for quantitative DCE‐MRI of the abdomen (2017)

The perfusion phantom reduced variability in quantitating contrast concentration and K<sup>trans</sup> values of human abdominal tissues across different MR units, but static phantom did not. The perfusion phantom has the potential to facilitate multi-institutional clinical trials employing quantitative DCE-MRI to evaluate various abdominal malignancies.
Correlation Among Obesity Factors in Stroke in Korea (2003)

As average life span has lengthened, the prevalence of stroke has been rising. Stroke can be a cause of death or leave irreversible neurologic deficit, so the prevention of stroke is drawing more and more social concern. There have been many suggested risk factors for stroke such as hypertension, atrial fibrillation, smoking, hyperlipidemia, carotid artery stenosis, diabetes mellitus (DM), obesity, cardiovascular disease, atherosclerosis, etc.. Among them, hypertension, hyperlipidemia, DM and atherosclerosis are common in the obese. Obesity is the excess accumulation state of fat and can be diagnosed when fat distribution is over 25% in men, 30% in women. Body mass index (BMI) and waist to hip (W/H) ratio are generally used in assessing obesity. Obesity seems to associate with stroke closely, but this association still has not been explained perfectly. Therefore, we investigated obesity factors in stroke subjects and referents.
Brain microenvironment-induced reduction in microRNAs to promote metastatic tumor growth, drug resistance, and survival. (2013)

e22030 Background: Brain metastases remain a serious obstacle that negatively impacts cancer patient survival. Most deaths due to cancer result from the progressive growth of metastatic, drug-resistant lesions. Moreover, the incidence of brain metastases is rising as a result of an aging population, superior imaging modalities, earlier cancer detection and more effective treatment of systemic disease. Methods: To investigate the role of the brain microenvironment in metastasis, tumor cells were co-cultured with astrocytes - the most abundant normal cell type in the metastatic brain tumor niche. This led to increased tumor cell viability, proliferation and chemoresistance. Microarray-based profiling was then performed to address the effect of the brain microenvironment on miRNA expression levels in tumor cells. Results: Profiling revealed that astrocyte co-culture reduced miRNAs-768-3p, 886-5p and 200c in tumor cells. Inhibition of miRNA-768-3p increased KRas expression, and a specific binding site was identified in the KRas 3’UTR and validated using a luciferase construct. miRNA-768-3p levels were reduced in patient-derived brain metastases relative to normal adult brain. Additionally, miRNA-768-3p was also lower in brain metastases compared to the primary tumors in matched paired samples. Our data demonstrates that the brain microenvironment modulates miRNA-768-3p in metastatic lesions to enhance KRas-mediated tumor survival and promote metastasis. Conclusions: The brain microenvironment regulates the expression of individual miRNAs in tumor cells to promote growth, survival and drug resistance. The brain microenvironment down-regulates the level of certain miRNAs to promote oncogenic signaling and tumor growth while our studies indicate that chemically-engineered miRNA mimics can restore the loss-of-function to reduce the viability of cancer cells. miRNA replacement therapy is a promising and novel therapeutic concept that could save thousands of patients from ineffective treatment, improve patient quality-of-life, overall survival and reduce the devastating impact of brain metastases on the healthcare system.
Phase-ordering kinetics of cemetery organization in ants (1998)

The clustering of dead bodies by ants is simulated, using a cellular automaton model, the rules of which are carefully derived from experiments. Starting from a random spatial distribution of corpses, a cemetery organizes itself into clusters of corpses. The dynamics of clustering can be compared to the phase-ordering kinetics of a bidimensional idealized magnetic system with a scalar conserved order parameter. In particular, scaling relations are found for the structure factor and the dynamics of cluster growth, which can be compared with those predicted by the theory of phase-ordering kinetics. Observed exponents are consistent with those expected in early stage phase-ordering kinetics.
Solvent Pressure Effects in Free Radical Reactions. 2. Reconciliation of the Gas and Condensed Phase Chlorination of Cyclopropane (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvent Pressure Effects in Free Radical Reactions. 2. Reconciliation of the Gas and Condensed Phase Chlorination of CyclopropaneJames M. Tanko and N. Kamrudin SulemanCite this: J. Am. Chem. Soc. 1994, 116, 12, 5162–5166Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/ja00091a020https://doi.org/10.1021/ja00091a020research-articleACS PublicationsRequest reuse permissionsArticle Views115Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modeling the Cochlea (2017)

… the assumption of a ‘passive’ cochlea, where elements are brought into mechanical oscillation solely by means of the incident sound, is not tenable. The degree of resonance of the elements of the cochlea can be measured, and the results are not compatible with the very heavy damping which must arise from the viscosity of the liquid. For this reason the ‘regeneration hypothesis’ is put forward, and it is suggested that an electromechanical action takes place whereby a supply of electrical energy is employed to counteract the damping.—“The physical basis of the action of the cochlea,” Thomas Gold (1948)
New Synthetic Approach for Azolopurines and Analogs (1982)

n e s , i .e .d e r i v a t i v e s o f 1 , 2 , 4 -t r iazolo(3.4-!)purine (3) and p y r r o l o ( 2 . 1 -! ) p u r i n e (z), and f o r some pyrazolo(3.4-2)pyrimidines( ~, l ~) .
Quelle place pour la dissection sous-muqueuse endoscopique dans le traitement des cancers superficiels sur oesophage de Barrett? (2016)

La dissection sous-muqueuse endoscopique permet la résection carcinologique des cancers superficiels digestifs. Sa supériorité sur la mucosectomie endoscopique a été démontrée pour les cancers superficiels épidermoïdes de l'oesophage. L'intérêt de la dissection sous-muqueuse dans le traitement des adénocarcinomes superficiels de l'oesophage reste controversé. Nous avons évalué l'efficacité et le taux de complications de la dissection sous-muqueuse dans le traitement des cancers superficiels développés sur oesophage de Barrett.
Identification of miRNA-eQTLs in maize mature leaf by GWAS (2020)

These identified significant miR-eQTLs contribute to the diversity of miRNA expression in the maize penal at the developmental stages of mature leaves in maize, and the positive and negative regulation between miRNA and its target genes has also been uncovered.
Drop Dead Data - What to expect Securing Data instead of Channels (2015)

In this paper we conduct a performance evaluation of privacy protocols for Information Centric Networking (ICN). Our contribution is three-fold: Firstly, we define a simple but complete performance framework for comparing current and future solutions. Secondly, we conjecture and prove the existence of unsafe replicas, namely cached content that remains available to users whose access has been revoked. Thirdly, we propose a performant protocol that solves the problem of unsafe replicas without tampering with the caching functionality of ICN.
Compact Thermal-Diffusivity-Based Temperature Sensors in 40-nm CMOS for SoC Thermal Monitoring (2017)

An array of temperature sensors based on the thermal diffusivity (TD) of bulk silicon has been realized in a standard 40-nm CMOS process. In each TD sensor, a highly digital voltage-controlled oscillator-based ΣΔ ADC digitizes the temperature-dependent phase shift of an electrothermal filter (ETF). A phase calibration scheme is used to cancel the ADC's phase offset. Two types of ETF were realized, one optimized for accuracy and one optimized for resolution. Sensors based on the accuracy-optimized ETF achieved a resolution of 0.36 °C (rms) at 1 kSa/s, and inaccuracies of ±1.4 °C (3σ, uncalibrated) and ±0.75 °C (3σ, room-temperature calibrated) from -40 °C to 125 °C. Sensors based on the resolution-optimized ETFs achieved an improved resolution of 0.21 °C (rms), and inaccuracies of ±2.3 °C (3σ, uncalibrated) and ±1.05 °C (3σ, room-temperature calibrated). The sensors draw 2.8 mA from supply voltages as low as 0.9 V, and occupy only 1650 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , making them some of the smallest smart temperature sensors reported to date, and well suited for thermal monitoring applications in systems-on-chip.
714 (2014)

Rittayamai, Nuttapol1,2; Katsios, Christina3,4; Beloncle, Francois3,5; Friedrich, Jan3,4; Brochard, Laurent3,4 Author Information
Safe Robot Learning in Assistive Devices through Neural Network Repair (2023)

Assistive robotic devices are a particularly promising field of application for neural networks (NN) due to the need for personalization and hard-to-model human-machine interaction dynamics. However, NN based estimators and controllers may produce potentially unsafe outputs over previously unseen data points. In this paper, we introduce an algorithm for updating NN control policies to satisfy a given set of formal safety constraints, while also optimizing the original loss function. Given a set of mixed-integer linear constraints, we define the NN repair problem as a Mixed Integer Quadratic Program (MIQP). In extensive experiments, we demonstrate the efficacy of our repair method in generating safe policies for a lower-leg prosthesis.
Brazilian Red Propolis—Chemical Composition and Botanical Origin (2006)

Propolis contains resinous substances collected by honey bees from various plant sources and has been used as a traditional folk medicine since ca 300 BC. Nowadays, the use of evidence-based complementary and alternative medicine (CAM) is increasing rapidly and so is the use of propolis in order to treat or support the treatment of various diseases. Much attention has been focused on propolis from Populus sp. (Salicaceae) and Baccharis dracunculifolia (Asteracea), but scientific information about the numerous other types of propolis is still sparse. We gathered six samples of red propolis in five states of Northeastern Brazil. The beehives were located near woody perennial shrubs along the sea and river shores. The bees were observed to collect red resinous exudates on Dalbergia ecastophyllum (L) Taub. (Leguminosae) to make propolis. The flavonoids of propolis and red resinous exudates were investigated using reversed-phase high-performance liquid chromatography and reversed-phase high-performance thin-layer chromatography. We conclude that the botanical origin of the reddish propolis is D. ecastophyllum. In areas where this source (D. ecastophyllum) was scarce or missing, bees were collecting resinous material from other plants. Propolis, which contained the chemical constituents from the main botanical origin, showed higher antimicrobial activity.