gebhart/patrepeval huggingface dataset:
Encouraging Communication and Community Through Making Books About Shared Experiences (2012)

Classroom Storytelling to Enhance Language and Literacy Skills (C-SHELLS) is a guide for helping preschool children “write” books. C-SHELLS is designed to promote communication by using storytelling and book making activities to promote child language and literacy skills and community by helping culturally and linguistically diverse children engage with peers, understand classroom routines, and develop socially appropriate and regulated behaviors. C-SHELLS helps teachers engage children, get them talking, help them make friends, and increase their school readiness. C-SHELLS activities do this by helping children work together to make picture books based on shared classroom experiences. C-SHELLS uses a simple, fun, and engaging approach. In our previous work, parents receiving home visits have used this approach to improve the language skills of children who are English language learners and children who have language delays or related disabilities. Preschool teachers can use this approach with children in their classrooms. C-SHELLS incorporates evidence-based practices that promote children’s language, literacy, and social development. C-SHELLS activities are designed to build preschool children’s communication and behavioral skills within their preschool community. As children learn to organize and talk about experiences, they are learning skills important for later reading and understanding what is read. The C-SHELLS process for creating books is straightforward, and many preschool teachers have made books with young children. However, the benefit of making books depends on children’s engagement, conversation, and participation. A 3-part process is recommended. First, share experiences by encouraging children’s conversation about and interest in an activity. Second, make books by writing down what children say about photos or drawings of the shared experience and organizing words and pictures into a book. Finally, use the books by reading and talking about the books together again and again.
SUNFISH Part 2: 24-Month Efficacy and Safety of Risdiplam in Patients with Type 2 or Non-Ambulant Type 3 Spinal Muscular Atrophy (2021)

Background/Purpose: Spinal muscular atrophy (SMA) is a severe, progressive neuromuscular disease caused by reduced levels of the survival of motor neuron (SMN) protein due to deletions/mutations of the SMN1 gene. Another gene, SMN2, produces only low levels of functional SMN protein. Risdiplam is an oral SMN2 pre-mRNA splicing modifier that increases levels of functional SMN protein and has been approved by the FDA for the treatment of patients with SMA, aged ≥2 months. This study's purpose is to determine the efficacy and safety of risdiplam in patients with Type 2 and non-ambulant Type 3 SMA after 24 months of treatment.
Expanding AirSTAR capability in an existing avionics design (2012)

AirSTARis a UAS designed for flight dynamics and control research; Allows control law injection in-line with internal research pilot commands; Project development in a series of phases; Developed project UAV/RC experience; Developed LaRC policies and procedures; Phase-III utilized a commercial-of-the-shelf (COTS) airframe; Phase-IV flew a 5.5% dynamically scaled generic transport model (GTM) aircraft.
Prognostic Importance of Postbypass Regional Wall-Motion Abnormalities in Patients Undergoing Coronary Artery Bypass Graft Surgery (1989)

Regional wall motion abnormalities (RWMA) detected by intraoperative transesophageal echocardiography (TEE) are thought to be sensitive markers of myocardial ischemia. To assess the prognostic significance of RWMA as compared with other less costly technologies such as electrocardiography (ECG) and hemodynamic measurements [blood pressure (BP) and pulmonary artery (PA) pressure], 50 patients were prospectively studied who were undergoing elective coronary artery bypass graft (CABG) surgery using continuous TEE, ECG (Holter), and hemodynamic measurements during the prebypass, postbypass, and early postoperative intensive care unit (ICU) periods (first 4 h). Echocardiographic and ECG evidence of ischemia was characterized during each of these three periods and related to adverse clinical outcomes (postoperative myocardial infarction, ventricular failure, and cardiac death). Clinicians were blinded to the TEE and ECG information. The prevalence of myocardial ischemia during the perioperative periods was as follows: prebypass, 20% (TEE) versus 7% (ECG); postbypass, 36% (TEE) versus 25% (ECG); ICU 25% (TEE) versus 16% (ECG). Neither prebypass TEE ischemia nor ECG ischemia occurring in any of the three periods predicted adverse outcome. In contrast, postbypass TEE ischemia was predictive of outcome: six of 18 patients with postbypass TEE ischemia had adverse outcomes versus 0 of 32 without TEE ischemia (P = 0.001). Seventy-three percent of the echocardiographic ischemic episodes occurred without acute change (+/- 20% of control) in heart rate, BP, or PA pressure. The authors conclude that: 1) prebypass myocardial ischemia was relatively uncommon, 2) the incidence of ECG and TEE ischemia was highest in the postbypass period, and 3) postbypass RWMA were related to adverse clinical outcome.
Sequential Ensemble Learning for Outlier Detection: A Bias-Variance\n Perspective (2016)

Ensemble methods for classification and clustering have been effectively used\nfor decades, while ensemble learning for outlier detection has only been\nstudied recently. In this work, we design a new ensemble approach for outlier\ndetection in multi-dimensional point data, which provides improved accuracy by\nreducing error through both bias and variance. Although classification and\noutlier detection appear as different problems, their theoretical underpinnings\nare quite similar in terms of the bias-variance trade-off [1], where outlier\ndetection is considered as a binary classification task with unobserved labels\nbut a similar bias-variance decomposition of error.\n In this paper, we propose a sequential ensemble approach called CARE that\nemploys a two-phase aggregation of the intermediate results in each iteration\nto reach the final outcome. Unlike existing outlier ensembles which solely\nincorporate a parallel framework by aggregating the outcomes of independent\nbase detectors to reduce variance, our ensemble incorporates both the parallel\nand sequential building blocks to reduce bias as well as variance by ($i$)\nsuccessively eliminating outliers from the original dataset to build a better\ndata model on which outlierness is estimated (sequentially), and ($ii$)\ncombining the results from individual base detectors and across iterations\n(parallelly). Through extensive experiments on sixteen real-world datasets\nmainly from the UCI machine learning repository [2], we show that CARE performs\nsignificantly better than or at least similar to the individual baselines. We\nalso compare CARE with the state-of-the-art outlier ensembles where it also\nprovides significant improvement when it is the winner and remains close\notherwise.\n
Induction of mammalian DNA topoisomerase I-mediated DNA cleavage and DNA winding by bulgarein (1993)

Bulgarein, a fungal metabolite, induced mammalian topoisomerase I-mediated DNA cleavage in vitro. The cleavage activity of bulgarein was comparable to that of camptothecin at a drug concentration range of 0.025-approximately 5 microM. The DNA cleavage induced by bulgarein was suppressed at concentrations above 12.5 microM. Treatment of a reaction mixture containing bulgarein and topoisomerase I with elevated temperature (65 degrees C) resulted in a substantial reduction in DNA cleavage, suggesting that the topoisomerase I-mediated DNA cleavage induced by bulgarein is through the mechanism of stabilizing the reversible enzyme-DNA "cleavable complex." Intensity of cleaved DNA fragments induced by bulgarein with topoisomerase I was different from that induced by camptothecin. Bulgarein inhibited catalytic activities of both topoisomerase I and topoisomerase II. The changes in absorption spectra of bulgarein in the visible region observed upon addition of increasing amounts of calf thymus DNA indicate that bulgarein interacts with DNA. DNA (un)winding assay by two-dimensional gel electrophoresis showed that bulgarein induced the winding of DNA in the opposite direction to that of an intercalator so that positively supercoiled molecules are produced. Thus, bulgarein represents a new class of drugs which stabilizes the cleavable complex of topoisomerase I and alters the structure of DNA in a manner leading to a tightening of the helical twist.
Design of Logic Circuit Technology for IBM System/370 Models 145 and 155 (1971)

Monolithic System Technology (MST) is a microelectronic circuit family consisting of high-density monolithic circuit chips on ceramic substrates. Using current-switch emitter follower (CSEF) logic, the technology is designed to provide a balanced reflection of cost and performance requirements. One version, MST-2, has been developed for use primarily in the middle range of System/370—the Models 145 and 155. The typical package usually consists of a single multi-circuit chip on a 16-pin module substrate, and the design embodies a number of recent interconnection and packaging developments that make it well suited to large-scale automated production.
Exome sequencing identifies MRPL3 mutation in mitochondrial cardiomyopathy (2011)

By combining exome sequencing in conjunction with genetic mapping, we have identified the first mutation in large mitochondrial ribosomal protein MRPL3 in a family of four sibs with hypertrophic cardiomyopathy, psychomotor retardation, and multiple respiratory chain deficiency. Affected sibs were compound heterozygotes for a missense MRPL3 mutation (P317R) and a large-scale deletion, inherited from the mother and the father, respectively. These mutations were shown to alter ribosome assembly and cause a mitochondrial translation deficiency in cultured skin fibroblasts resulting in an abnormal assembly of several complexes of the respiratory chain. This observation gives support to the view that exome sequencing combined with genetic mapping is a powerful approach for the identification of new genes of mitochondrial disorders.
The performance impact of BPG security (2005)

The border gateway protocol possesses security vulnerabilities, because speakers can lie. Proposed security protocols can address the vulnerabilities, but can significantly increase the performance overheads, which prevent their real-world deployment. Public key cryptography can address these vulnerabilities. We report our research into analyzing recently proposed security protocols and building simulation frameworks to evaluate their costs, and designing and validating techniques to reduce them.
Portable Multi-Hydrophone Array for Field and Laboratory Measurements of Odontocete Acoustic Signals DURIP (2013)

Abstract : The major goal is to build an array in order to measure the directionality of whistle and clicks produced by odontocetes. Beam patterns and depth profiles of acoustic signals of several species of odontocetes can be collected and analyzed in order to provide better verification of signals collected via passive acoustic monitoring. Additionally, because the array is versatile and portable, other sound sources can be measured and described in various environments.
The utility of erythrocyte sedimentation rate values and white blood cell counts after spinal deformity surgery in the early (≤3 months) post-operative period (2012)

In non-infected spinal fusion surgeries, erythrocyte sedimentation rates are in the abnormal range in 78% of patients at 1 month and in 53% of patients at 3 months post-operatively, suggesting that the erythrocyte sedimentation rate is of limited diagnostic value in the early post-operative period.
Variation in the artifact assemblages from five Oxbow sites (1988)

Variation in the Artifact Assemblages from Five Oxbow Sites (
In Vitro Evaluation of Cenderitide‐Eluting Stent I —An Antirestenosis and Proendothelization Approach (2014)

Despite the success that drug-eluting stents (DESs) have achieved for minimizing in-stent restenosis (ISR), the antirestenotic agents used in DES have been implicated in delayed endothelial healing and impairment of endothelial functions. Cenderitide (CD-NP) is a novel antiproliferation chimeric peptide of semiendothelial origin; thus, this paper aims to demonstrate the selectivity aspect of this new peptide via in vitro evaluation on key players in ISR-smooth muscle cells (SMCs) and endothelial cells. The microbicinchoninic acid protein assay was used to investigate the CD-NP release from films and stents. Cenderitide-containing films blended with poly(ethylene glycol) and its copolymer exhibited higher release kinetics compared with neat poly(ε-caprolactone) (PCL) formulation. Cenderitide-eluting stents (CES) was produced by coating bare metallic stents with CD-NP entrapped PCL using an ultrasonic spray coater. The investigation of CD-NP on in vitro cells revealed that CD-NP inhibits human coronary smooth muscle cells (HCaSMCs) proliferation but exhibits no effects on human umbilical vein endothelial cells (HUVECs) proliferation. Moreover, CD-NP released up to 7 days displayed inhibitory effects on SMCs proliferation. The CES produced in this work shows that the released CD-NP inhibits HCaSMCs proliferation but did not hamper HUVECs proliferation in vitro, suggesting that it has potential to reduce ISR without retarding the endothelialization healing in vivo.
Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes. (1988)

Transforming growth factor alpha (TGF-alpha) is a 50-amino acid peptide, previously demonstrated only in transformed cell lines and human tumors, which is structurally homologous to epidermal growth factor (EGF). TGF-alpha expression in keratinocytes from normal individuals, patients with psoriasis, and patients with malignant skin diseases was investigated using an mAb raised against synthetic human TGF-alpha. mAb A1.5 reacted with TGF-alpha, but not EGF, in a sensitive ELISA. Keratinocytes in eight nodular basal cell carcinomas, one morpheic basal cell carcinoma, and one squamous cell carcinoma demonstrated intense membranous immunoperoxidase staining with mAb A1.5. Of even greater interest was the observation that the overlying normal epidermis, as well as the epidermis from five normal skin specimens, were stained by the mAb. Keratinocytes in plaques from 18 psoriasis patients were more intensely stained than those from normal skin. Cultured normal keratinocytes demonstrated membranous staining with mAb A1.5. Absorption of mAb A1.5 with synthetic human TGF-alpha completely removed the reactivity of mAb A1.5 with both basal cell tumors and normal epidermis. The demonstration of TGF-alpha in normal keratinocytes suggests that it plays a role in normal keratinocyte growth, wound healing, and in the pathogenesis of acanthosis.
Supplementary Figure 8 from MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma (2023)

&lt;p&gt;PDF file - 264K, Quantitation of protein expression.&lt;/p&gt;
Multimodal 3D and 2D face authentication approachusing extended LBP and statistic local features proposed (2013)

International audience
Ratiometric detection and imaging of endogenous hypochlorite in live cells and in vivo achieved by using an aggregation induced emission (AIE)-based nanoprobe (2016)

An AIE-based fluorescent nanoprobe (MTPE-M) has been developed and used for ratiometric detection of hypochlorite with high selectivity and sensitivity. More importantly, its application in live cells and zebrafish for ratiometric imaging of endogenous ClO(-) has also been achieved.
[Persistence of virus in swine stock and breeding farms following an outbreak of Aujeszky's disease]. (1984)

On seven fattening farms and seven breeding farms, investigations were carried out to examine whether Aujeszky virus was capable of persisting in particular animal groups or units of the farm as a productive infection following a virologically verified outbreak. After an outbreak on fattening farms, virus persisted temporarily as newly arrived piglets became systematically infected. On the farms on which this could be accurately followed, virus persistence continued for at least 1 1/2 to 2 months. However, this cycle of infection was found to be interrupted on each farm within approximately three months after the outbreak, which resulted in a gradual return to a totally sensitive animal population, so that new outbreaks could occur. On the seven swine breeding farms, virus persistence in the farrowing house was examined by placing seronegative sentinel piglets with sows during the immediate post-partum period. Twelve sentinel piglets were placed in the various farrowing houses for a total period of sixty-seven weeks, during which time 172 sows farrowed. None of these piglets became seropositive during their stay on the breeding farms. The results of this study show that Aujeszky's disease virus did not persist on breeding farms and that the productive infection on fattening farms in only transient following an outbreak. Therefore, it is very likely that new outbreaks of the disease are due to reintroduction of Aujeszky's disease virus on the farm. Though the role of latent carrier animals cannot be totally disregarded, natural reactivation of latent virus is believed an exception rather than the general rule.
Supplementary Figure S5 from Identification of Patients with Recurrent Glioblastoma Who May Benefit from Combined Bevacizumab and CCNU Therapy: A Report from the BELOB Trial (2023)

&lt;p&gt;Mutations segregate in distinct molecular subtypes.&lt;/p&gt;
A platform for implantable medical device validation (2010)

Designing bug-free medical device software is difficult, especially in complex implantable devices that may be used in unanticipated contexts. In the 20-year period from 1985 to 2005, the US Food and Drug Administration's (FDA) Maude database records almost 30,000 deaths and almost 600,000 injuries from device failures [8]. There is currently no formal methodology or open experimental platform to validate and verify the correct operation of medical device software. To this effect, a real-time Virtual Heart Model (VHM) has been developed to model the electrophysiological operation of the functioning (i.e. during normal sinus rhythm) and malfunctioning (i.e. during arrhythmia) heart. We present a methodology to extract timing properties of the heart to construct a timed-automata model. The platform exposes functional and formal interfaces for validation and verification of implantable cardiac devices. We demonstrate the VHM is capable of generating clinically-relevant response to intrinsic (i.e. premature stimuli) and external (i.e. artificial pacemaker) signals for a variety of common arrhythmias. By connecting the VHM with a pacemaker model, we are able to pace and synchronize the heart during the onset of irregular heart rhythms. The VHM has been implemented on a hardware platform for closed-loop experimentation with existing and virtual medical devices. The VHM allows for exploratory electrophysiology studies for physicians to evaluate their diagnosis and determine the appropriate device therapy. This integrated functional and formal device design approach will potentially help expedite medical device certification for safer operation.
Applications of thin graded-index films to solar absorbers (1977)

The solar absorptance of a single ideal film on an idealized metallic substrate has been calculated as a function of its optical constants to determine the optimum parameters for selective absorber applications. High normal solar absorptances (>0.9) are possible for single uniform interference films if n < 1.5 and 0.2 < k < 0.8, values that are achievable using cermet materials. Grading the refractive index of single interference films improves the absorptance, with optimum results given by a uniformly increasing dielectric constant through the layer. With such a linear grading to air, normal solar absorptances of greater than 0.9 can be achieved for n < 1.5 and 0.1 < k < 5. Grading an absorbing material with a dielectric also improves the performance of the absorbing material. For bulk films, the optimum profile with minimum material is one where the dielectric constant increases slowly at the surface of the film.
Orca: a language for parallel programming of distributed systems (1992)

A detailed description is given of the Orca language design and the design choices are discussed. Orca is intended for applications programmers rather than systems programmers. This is reflected in its design goals to provide a simple, easy-to-use language that is type-secure and provides clean semantics. Three example parallel applications in Orca, one of which is described in detail, are discussed. One of the existing implementations, which is based on reliable broadcasting, is described. Performance measurements of this system are given for three parallel applications. The measurements show that significant speedups can be obtained for all three applications. The authors compare Orca with several related languages and systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Elektronikus dokumentumok: a legmunkaigényesebb dokumentumfajta (2002)

The method described here aims at a complex approach of registering, organising and providing access to electronic documents in a library envi-ronment. Registration of available electronic documents from subscribed databases, electronic journals to free Internet documents of higher edu-cational and scientific value is based on the cataloguing services of the ILS. The catalogue records - in addition to bibfiographic information - contain subject classification numbers, subject headings, exact description of the availabiuty of the documents with URLs if relevant. The documents thus become available through the online catalogue, which presents them merged into the general col-lection of the Ubrary. For those looking for electronic documents only and prefer gateway type access to them automated processes create al-phabetic and thematic lists based on the MARC records and place them on the library home page. The items on the lists select some of the information present in the bibliographic record concen-trating on titles, summaries, contents and above all URLs and other availabiuty information. The sys¬tem is made complete with a URL checking mechanism, which warn cataloguers of changes in the availabiuty of documents. The URL and data maintenance work is again done in the MARC records with normal cataloguing tools. (http//www.HbMnideb.hu - both for the catalogue with electronic documents and the web lists.)
SOX7 and SOX18 are essential for cardiogenesis in Xenopus (2005)

Early in vertebrate development, endodermal signals act on mesoderm to induce cardiogenesis. The F-type SOXs SOX7 and SOX18beta are expressed in the cardiogenic region of the early Xenopus embryo. Injection of RNAs encoding SOX7 or SOX18beta, but not the related F-type SOX, SOX17, leads to the nodal-dependent expression of markers of cardiogenesis in animal cap explants. Injection of morpholinos directed against either SOX7 or SOX18mRNAs lead to a partial inhibition of cardiogenesis in vivo, while co-injection of SOX7 and SOX18 morpholinos strongly inhibited cardiogenesis. SOX7 RNA rescued the effects of the SOX18 morpholino and visa versa, indicating that the proteins have redundant functions. In animal cap explants, it appears that SOX7 and SOX18 act indirectly through Xnr2 to induce mesodermal (Eomesodermin, Snail, Wnt11), organizer (Cerberus) and endodermal (endodermin, Hex) tissues, which then interact to initiate cardiogenesis. Versions of SOX7 and SOX18 with their C-terminal, beta-catenin interaction domains replaced by a transcriptional activator domain failed to antagonize beta-catenin activation of Siamois, but still induced cardiogenesis. These observations identify SOX7 and SOX18 as important, and previously unsuspected, regulators of cardiogenesis in Xenopus.