gebhart/patrepeval huggingface dataset:
Functional Roles of a C-terminal Signaling Complex of CaV1 Channels and A-kinase Anchoring Protein 15 in Brain Neurons (2011)

Regulation of CaV1.2 channels in cardiac myocytes by the β-adrenergic pathway requires a signaling complex in which the proteolytically processed distal C-terminal domain acts as an autoinhibitor of channel activity and mediates up-regulation by the β-adrenergic receptor and PKA bound to A-kinase anchoring protein 15 (AKAP15). We examined the significance of this distal C-terminal signaling complex for CaV1.2 and CaV1.3 channels in neurons. AKAP15 co-immunoprecipitates with CaV1.2 and CaV1.3 channels. AKAP15 has overlapping localization with CaV1.2 and CaV1.3 channels in cell bodies and proximal dendrites and is closely co-localized with CaV1.2 channels in punctate clusters. The neuronal AKAP MAP2B, which also interacts with CaV1.2 and CaV1.3 channels, has complementary localization to AKAP15, suggesting different functional roles in calcium channel regulation. Studies with mice that lack the distal C-terminal domain of CaV1.2 channels (CaV1.2ΔDCT) reveal that AKAP15 interacts with neuronal CaV1.2 channels via their C terminus in vivo and is co-localized in punctate clusters of CaV1.2 channels via that interaction. CaV1.2ΔDCT neurons have reduced L-type calcium current, indicating that the distal C-terminal domain is required for normal functional expression in vivo. Deletion of the distal C-terminal domain impairs calcium-dependent signaling from CaV1.2 channels to the nucleus, as shown by reduction in phosphorylation of the cAMP response element-binding protein. Our results define AKAP signaling complexes of CaV1.2 and CaV1.3 channels in brain and reveal three previously unrecognized functional roles for the distal C terminus of neuronal CaV1.2 channels in vivo: increased functional expression, anchoring of AKAP15 and PKA, and initiation of excitation-transcription coupling.
Study of Toxin Production by Isolates of Stachybotrys chartarum and Memnoniella echinata Isolated during a Study of Pulmonary Hemosiderosis in Infants (1998)

A cluster of cases of pulmonary hemosiderosis among infants was reported in Cleveland, Ohio, during 1993 and 1994. These unusual cases appeared only in infants ranging in age from 1 to 8 months and were characterized by pulmonary hemorrhage, which caused the babies to cough up blood. A case-control study identified major home water damage (from plumbing leaks, roof leaks, or flooding) as a risk factor for development of pulmonary hemorrhage in these infants. Because of an interest in the possibility that trichothecene mycotoxins might be involved in this illness, a number of isolates of Stachybotrys chartarum were grown in the laboratory on rice, and extracts were prepared and analyzed both for cytotoxicity and for specific toxins. Two isolates of Memnoniella echinata, a fungus closely related to S. chartarum, were also included in these studies. S. chartarum isolates collected from the homes were shown to produce a number of highly toxic compounds, and the profiles of toxic compounds from M. echinata were similar; the most notable difference was the fact that the principal metabolites produced by M. echinata were griseofulvins.
A MEMS-CMOS Microsystem for Contact-Less Temperature Measurements (2021)

This paper presents a microsystem suitable for contact-less human body temperature measurements, as well as for presence, motion and proximity detection. It consists of a 130-nm CMOS-SOI MEMS (Micro-Electro Mechanical System) thermal sensor, referred to as &#x201C;TMOS&#x201D;, and its 130-nm CMOS interface circuit. The TMOS, based on a micromachined transistor, being an active device, features advantages in terms of internal gain: with optimal biasing, indeed, the TMOS achieves 274-<inline-formula> <tex-math notation="LaTeX">$\mu \text{V}/^\circ \text{C}$ </tex-math></inline-formula> input-referred sensitivity at 3-cm distance and 50.33&#x00B0; field-of-view (FOV), outperforming thermopile detectors. The sensor and the interface circuit, featuring a chopper-stabilized-based analog readout with a 12-bit SAR ADC (Successive Approximation Register Analog-to-Digital Converter), were mounted in the same package and extensively measured: the microsystem achieves repeatability and &#x00B1;0.17&#x00B0;C precision, thus satisfying the requirements for contact-less human body temperature measurements; furthermore, its performance as presence, motion and proximity detector was also verified.
SimNet: A new algorithm for measuring brain networks similarity (2015)

Measuring similarity among graphs is recognized as a non-trivial problem. Most of the algorithms proposed so far ignore the spatial location of vertices, which is a crucial factor in the context of brain networks. In this paper, we present a novel algorithm, called “SimNet”, for measuring the similarity between two graphs whose vertices represent the position of sources over the cortex. The novelty is to account for differences at the level of spatially-registered vertices and edges. Simulated graphs are used to evaluate the algorithm performance and to compare it with methods reported elsewhere. Results show that SimNet is able to quantify the similarity between two graphs under a spatial constraint based on the 3D location of edges. The application of SimNet on real data (dense EEG) reveals the presence of spatially-different brain networks modules activating during cognitive activity.
ChemInform Abstract: Synthesis of Isocoumarins and α‐Pyrones via Palladium‐Catalyzed Annulation of Internal Alkynes. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
(CL-218)FACTORS THAT DISCRIMINATE BETWEEN MONOVISION AND BIFOCAL CONTACT LENS PREFERENCE. (2000)

Dutoit, Renee DipOptom, MPhilOptom; Situ, Ping BMed, MSc; Simpson, Trefford DipOptom, PhD; Fonn, Desmond DipOptom, MOptomAuthor Information
Narcissus Alkaloids. Part 26. Alkaloids from Narcissus angustifolius subsp. transcarpathicus (Amaryllidaceae). (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
Molecular conductance switching via controlled alteration of electron delocalization: Quinone-modified oligo(phenylenevinylene) (2009)

Reversible conductance switching in single quinone-modified oligo(phenylenevinylene)s (OPV) was studied using electrochemical scanning tunnel microscopy. The switching was achieved through electrochemical oxidation/reduction in the quinone moiety of the molecule. The strong electron delocalization of the reduced hydroquinone-OPV structure resulted in the high-conductance state, whereas the weaker delocalization of the oxidized quinone-OPV was responsible for the low-conductance state. The ratio of the conductances was measured to be in excess of 40.
Observation of Interband Transitions in Arsenic (1968)

Low on the EL, '-Kg' mass difference similar to those presented in this paper. These workers were apparently ledas mere weto consider as the source of the low cutoff a possible quadratic strong interaction of
On the Modelling and the Prediction of the Vibroacoustic Behaviour of an Aircraft Structure (1992)

This paper summarizes the first step of a long-term research program focusing on the modeling and prediction of the vibrational and acoustical behavior of an aircraft structure.The final goal pursued is to provide the aeronautical industry with guidance for cabin sound-proofing with the help of a versatile, physical and easy-touse model.Two main subjects tackled in this paper are: The free vibrational behavior of the aircraft structure. Effects of the rear pressure bulkhead on the cabin noise. SOMMAIRECe papier rsume la premire tape d'une srie de programme de recherche portant sur la modlisation et la prdiction du comportement vibratoire et acoustique de structure d'avion.L'objectif final est de fournir l'industrie aronautique, l'aide d'un modle qui est la fois physique et propice l'analyse paramtrique, des directives en vue de l'amlioration de la discrtion acoustique dans la cabine.Deux sujets principaux traits sont les suivants: Comportement de vibration libre de la structure d'avion.(2) Effets de la cloison arrire sur le bruit interne de la cabine.1 .
Wafer-scale production of carbon nanofiber probes (2009)

The 4in. wafer-scale production of probes tipped with single carbon nanofibers (CNF probes) for scanning probe microscope was achieved by an Ar+-ion-irradiation method. For the wafer-scale production, an arrangement of commercial-type Si cantilevers (tetrahedral Si tips), onto which single CNFs are grown, was optimized to contain 288 cantilevers in a 4in. wafer. The ion-induced CNFs were then batch grown in the wafer scale. Scanning electron microscope observation of 50 of 288 probes randomly selected revealed that the CNFs were linear shaped, ∼400nm in average length and ∼9nm in average radius, and that ∼80% of the probes batch grown were suitable for practical use as qualified probes. Atomic force microscope image of a densely distributed plastic nanocolumn array obtained by the batch-grown CNF probe was clearer and less distorted, compared to that attained by a conventional Si probe. Thus, the ion-irradiation method opened up new route for the wafer-scale production of CNF probes for practical daily use.
Improving the Capacity and Performance of Air-Conditioning Screw Compressors (2006)

Traditional compressor design methods make it very difficult to make significant improvements to screw compressors required for refrigeration and air conditioning applications. The principles which determine the optimum design of such machines are reviewed and, in some cases, redefined. These include rotor profiling, configuration and proportions, clearance distribution and bearing clearances and it is shown that there are conflicting requirements for them when attempting to obtain optimum performance. The best result can thus only be obtained by consideration of all the relevant parameters in an optimisation procedure, which leads to rotor designs that vary according to the specific duty of a machine, rather than follow a standard pattern An outline description is given of a process modelling procedure which has been developed to optimise the design of a compressor by the use of multi variable minimisation methods that take simultaneous account of all these parameters As a result of a collaborative project between industry and an academic institution, this procedure was applied to the design of a new refrigeration screw compressor, which was then built and tested. Its performance was then compared with that of the machine it was intended to replace. It is shown that the optimised design was up to 9% better than the original machine.
Modular Organization of Human Extrastriate Visual Cortex: Evidence from Cytochrome Oxidase Pattern in Normal and Macular Degeneration Cases (1994)

The human extrastriate occipital cortex contains several visual areas that are probably analogues of macaque areas V2, V3, VP, V4 and V5. Tracing of callosal connections has led to the anatomical identification of these areas and to the characterization of some of them by cyto- and myeloarchitecture (Clarke and Miklossy, 1990). The pattern of cytochrome oxidase activity in these visual areas is now described in a normal case and in a case of age-related bilateral macular degeneration. In normal cortex, the laminar distribution of cytochrome oxidase activity was similar in V2, V3, VP, V4 and V5; a prominent dark band covered most of layers III and IV, and its upper and lower limits were gradual. In V2, V3, V4 and V5 but not VP, layer II tended to be darker than the infragranular layers. The overall intensity of the staining varied between areas: VP was very light, V2, V3 and V4 were darker, and V5 was very dark. A different, two-band pattern of cytochrome oxidase activity was found in a restricted region of the posterosuperior precuneus. The bilateral age-related macular degeneration had led to a great loss of ganglion cells in the central, but not in the peripheral retinae. The central representation in the lateral geniculate nuclei showed abnormally weak staining for cytochrome oxidase, particularly in the parvocellular layers. In the cortex, the contrast between lightly and darkly stained regions was greater than in the normal case. In particular, V5 was very heavily stained, and in V1 and V2 there were two different types of dark stripes that may represent compartments driven predominantly by the magnocellular system.
A statistical approach for selecting discriminative features of spatial regions of interest (2007)

We propose a statistical approach based on a supervised framework for reducing the dimensionality of the feature space when characterizing and classifying spatial Regions of Interest (ROIs). Our approach employs the statistical techniques of Bootstra
Ligand-Carrying Gas-Filled Microbubbles:  Ultrasound Contrast Agents for Targeted Molecular Imaging (2004)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTLigand-Carrying Gas-Filled Microbubbles: Ultrasound Contrast Agents for Targeted Molecular Imaging†Alexander L. KlibanovView Author Information Cardiovascular Division, University of Virginia, Charlottesville, Virginia 22908Cite this: Bioconjugate Chem. 2005, 16, 1, 9–17Publication Date (Web):December 30, 2004Publication History Received24 April 2004Revised8 December 2004Published online30 December 2004Published inissue 1 January 2005https://pubs.acs.org/doi/10.1021/bc049898yhttps://doi.org/10.1021/bc049898yreview-articleACS PublicationsCopyright © 2005 American Chemical SocietyRequest reuse permissionsArticle Views3210Altmetric-Citations207LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biopolymers,Bubbles,Ligands,Peptides and proteins,Ultrasound Get e-Alerts
Periodontal regeneration in aggressive periodontitis patients: A systematic review of the literature (2016)

The aim of the present study was to systematically review the existing literature on periodontal regenerative procedures in individuals affected by aggressive periodontitis (AgP). An electronic and manual search was performed using an ad hoc prepared search string. All types of study designs were considered acceptable for inclusion. Data about treated patients, baseline clinical parameters, type of surgery, and outcomes were extracted and recorded. A narrative evaluation of the results was performed. After the article-selection process, a total of 22 full-texts were included in the qualitative synthesis. Twelve papers were case reports; one was a retrospective study; six were non-randomized, comparative studies; and three papers were published on two randomized, controlled trials (RCT). Various biomaterials and surgical techniques were described in the included papers. Based on the existing literature, even considering the relatively low level of evidence, periodontal regenerative surgery could be successfully performed in patients affected by AgP. There is a substantial need of high-quality RCT to support this.
Formation of three-dimensionally integrated nanocrystalline silicon particles by dip-coating method (2015)

Printable technologies using silicon nanoink, in which nanocrystalline silicon (nc-Si) quantum dots are dispersed in solvents, are promising for novel electron and photonic device applications. The dip-coating method is applied for the first time to fabricate three-dimensionally integrated structures of nc-Si quantum dots with a uniform size of 10 nm prepared by the very high frequency plasma decomposition of silane gas. We have clarified the major problem of the dip-coating method, which is the formation of stripe structures. To circumvent this problem, we have proposed two methods: coating onto line-and-space-patterned substrates and utilization of electrophoresis force. We have successfully demonstrated the control of the position and number of layers of nc-Si by using a line-and-space-patterned substrate, however, with a limited shape. We have clarified the conditions of the formation of stripe-free regions by varying applied voltage and nc-Si concentration in the electrophoresis method.
Polycondensation of Malononitrile and Methylenedimalononitrile with Bis(chloromethyl)Aromatic Compounds Using Triethylamine as Acid Acceptor (1973)

Abstract Malononitrile was found to undergo condensation reaction with benzyl chloride to give dibenzylmalononitrile in a quantitative yield under mild conditions when an organic base such as triethylamine was used as acid acceptor in dimethyl sulfoxide. The reaction was applied to the polycondensation of malononitrile and methylenedimalononitrile with p-xylylene dichloride and p,p′-bis(chloromethyl)diphenyl ether, polymers with intrinsic viscosity 0.14–0.22 dl/g being obtained in quantitative yields.
Comparative Study of Sonophotocatalytic, Photocatalytic, and Catalytic Activities of Magnesium and Chitosan-Doped Tin Oxide Quantum Dots (2022)

The present study demonstrates the hydrothermal synthesis of SnO<sub>2</sub> quantum dots (QDs) doped with different concentrations (2, 4 wt %) of magnesium (Mg) and a fixed amount of chitosan (CS). The obtained samples were investigated through a number of characterizations for optical analysis, elemental composition, crystal structure, functional group presence, interlayer spacing, and surface morphology. The XRD spectrum revealed the tetragonal structure of SnO<sub>2</sub> with no significant variations occurring upon the addition of CS and Mg. The crystallite size of QDs was reduced by incorporation of dopants. The optical absorption spectra revealed a red shift, assigned to the reduction of the band gap energy upon doping. TEM analysis proved that the few nanorod-like structures of CS overlapped with SnO<sub>2</sub> QDs, and agglomeration was observed upon Mg doping. The incorporation of dopants little enhanced the <i>d</i>-spacing of SnO<sub>2</sub> QDs. Moreover, the synthesized nanocatalyst was utilized to calculate the degradation percentage of methylene blue (MB) dye. Afterward, a comparative analysis of catalytic activity, photocatalytic activity, and sonophotocatalytic activity was carried out. Notably, 4% Mg/CS-doped QDs showed maximum sonophotocatalytic degradation of MB in basic medium compared to other activities. Lastly, the prepared nanocatalyst was found to be efficient for dye degradation in any environment and inexpensive.
Regulation of Naturally Acquired Mucosal Immunity to Streptococcus pneumoniae in Healthy Malawian Adults and Children (2012)

Worldwide, invasive pneumococcal disease caused by Streptococcus pneumoniae is most common in young children. In adults, disease rates decline following intermittent colonization and the acquisition of naturally acquired immunity. We characterized mucosal and systemic pneumococcal-specific T-cell responses in African children and adults who contend with intense rates of colonization, up to 100% and 60% respectively. We find most Malawian children have high pneumococcal-specific T-cell responses in tonsil tissue and peripheral blood. In addition, frequent commensalism generates CD25(hi) (Tregs) which modulate mucosal pneumococcal-specific T-cell responses in some children and ≥50% of adults. We propose that immune regulation may prolong pneumococcal colonization and predispose vulnerable individuals to disease.
Efficient Quantum Transforms (1997)

Quantum mechanics requires the operation of quantum computers to be unitary, and thus makes it important to have general techniques for developing fast quantum algorithms for computing unitary transforms. A quantum routine for computing a generalized Kronecker product is given. Applications include re-development of the networks for computing the Walsh-Hadamard and the quantum Fourier transform. New networks for two wavelet transforms are given. Quantum computation of Fourier transforms for non-Abelian groups is defined. A slightly relaxed definition is shown to simplify the analysis and the networks that computes the transforms. Efficient networks for computing such transforms for a class of metacyclic groups are introduced. A novel network for computing a Fourier transform for a group used in quantum error-correction is also given.
A new multi-view regression approach with an application to customer wallet estimation (2006)

Motivated by the problem of customer wallet estimation, we propose a new setting for multi-view regression, where we learn a completely unobserved target (in our case, customer wallet) by modeling it as a "central link" in a directed graphical model, connecting multiple sets of observed variables. The resulting conditional independence allows us to reduce the maximum discriminative likelihood estimation problem to a convex optimization problem for exponential linear models. We show that under certain modeling assumptions, in particular, when there exist two conditionally independent views and the noise is Gaussian, this problem can be reduced to a single least squares regression. Thus, for this specific, but widely applicable setting, the "unsupervised" multi-view problem can be solved via a simple supervised learning approach. This reduction also allows us to test the statistical independence assumptions underlying the graphical model and perform variable selection. We demonstrate the effectiveness of our approach on our motivating problem of customer wallet estimation and on simulation data.
Association Between Plasma Antibody Responses and Risk for Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome (2018)

Antibody profiles that include plasma IgM, Lam-IgM, Lam-IgG, and/or GXM-IgM may have value in furthering our understanding of C-IRIS pathogenesis and hold promise as candidate biomarkers of C-IRIS risk.
Supplementary Figures from ATIP3, a Novel Prognostic Marker of Breast Cancer Patient Survival, Limits Cancer Cell Migration and Slows Metastatic Progression by Regulating Microtubule Dynamics (2023)

&lt;p&gt;Supplementary Figures PDF file - 486K, Figure S1. Low levels of ATIP3 associate with decreased overall and relapse-free survival of the patients;Figure S2. Anti-metastatic effects of ATIP3 in vivo; Figure S3. ATIP3 inhibits breast cancer cell proliferation and migration; Figure S4. ATIP3 regulates MT dynamics; Figure S5. Characterization of ATIP3 domains&lt;/p&gt;