gebhart/patrepeval huggingface dataset:
ML frame synchronization for the Gaussian channel with ISI (2002)

The problem of locating a periodically inserted frame synchronization pattern in random data for a binary pulse amplitude modulated (PAM) digital communication system over an additive white Gaussian noise (AWGN) channel with intersymbol interference (ISI) is considered. The optimum maximum-likelihood (ML) decision rule for frame synchronization over an AWGN channel with ISI is derived. The performances of an ordinary correlation rule are compared with those of the ML rule. A high SNR (signal-to-noise ratio) approximation to the ML rule, which can be implemented as simply as the correlation rule, is also derived.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Identification and characterization of mouse small intestine mucosal receptors for Escherichia coli K-12(K88ab) (1986)

Adhesion of 3H-labeled Escherichia coli K-12(K88ab) to CD-1 mouse small intestine mucus and brush border preparations, immobilized on polystyrene, was studied. E. coli K12(K88ab) was shown to adhere readily to either crude mucus or brush border preparations, but not to bovine serum albumin. In contrast, the nearly isogenic E. coli K-12 strain, i.e., lacking the K88ab plasmid, did not bind well to either mucus, brush borders, or bovine serum albumin. The adhesion of E. coli K-12(K88ab) to both mucus and brush borders required pilus expression (i.e., growth at temperatures greater than 18 degrees C) and was inhibited by pretreatment of either mucus or brush borders with trypsin, pronase, or sodium metaperiodate and by the presence of D-galactosamine. Crude mucus was fractionated by gel filtration, and the proteins in receptor-containing fractions were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Separated proteins were Western blotted to nitrocellulose. Adhesion of 35SO4-labeled E. coli K-12(K88ab) and 35SO4-labeled E. coli K-12 to Western blots followed by autoradiography revealed two E. coli K-12(K88ab)-specific mucus receptor proteins (57 and 64 kilodaltons). Brush borders contained the same two receptor proteins present in mucus and an additional 91-kilodalton receptor protein.
PULMONARY LIGAMENT METASTASIS ABRUPTLY DEVELOPED AND RAPIDLY ENLARGED 15 YEARS AFTER RESECTION OF RENAL CANCER-A CASE REPORT- (2003)

今回われわれは,腎癌根治術後13年目に孤立性肺転移, 15年目に急速増大した肺靱帯転移を発見し,その両転移巣を同時に切除しえた症例を経験したので報告する.症例は77歳,女性, 1987年左腎細胞癌にて左腎摘出術施行. 2000年4月,胸部X線検査で右肺にcoin lesionが出現.胸部CT上,右肺S3に9mmの腫瘤を認めた. 2002年1月肺穿刺細胞診施行,腎細胞癌肺転移と診断.その際前回CTではなかった, 3cmの腫瘤を右肺S10に認めた.両病巣とも肺部分切除にて切除.病理学的にS3は肺内転移であったが, S10病変は肺外肺靱帯内への転移で,且つ両転移巣間に病理組織学的な違いは観察されなかった.腎癌転移巣では陰影増大の速度や大きさのみで手術適応を判断すべきでなく,その多様な病態を考慮して治療法を選択すべきと考えられた.腎癌の肺靱帯への転移は極めて稀で,調べ得る限り報告がないため報告した.
A note on fractional calculus and the image method for dielectric spheres (1995)

In this note, we present an alternative mathematical way of expressing electrostatic image charges for dielectric spheres using the concept of fractional calculus. It is shown that the distributions of image charges for the dielectric sphere (Lindell's solution) and the image charges for the perfectly conducting ungrounded spheres (Lord Kelvin's solution) can be mathematically related via fractional differintegration, and that the order of such fractional operators depend of the dielectric property of the sphere, i.e., its dielectric constant.
Surmortalité régionale et causes de décès en Belgique et en Wallonie. Tables de mortalité 1979-1982 (1987)

André Robert. Surmortalité régionale et causes de décès en Belgique et en Wallonie. Tables de mortalité 1979-1982 . In: Bulletin de la Classe des lettres et des sciences morales et politiques, tome 73, 1987. pp. 208-309.
Softening traction-separation laws of concrete for determining double-K fracture parameters (2000)

Aimed at the problem that the initial fracture toughness K ini Ic depends on the shape of softening traction separation law used in the calculation, this paper point out that, the values of w s and σ s at the breaking point on the bilinear softening traction separation curve will influence on the K ini Ic . Under the condition of w s being equal to critical crack tip opening displacement and introducing a parameter named λ which is associated with the deformation property of concrete, the determination of K ini Ic will directly depend on the value of λ . To compare the results of K ini Ic evaluated with different shapes of softening traction separation law with that measured from the experiment on three point bending notched beams, the shape of softening traction separation law which makes the above two results agree well can be obtained to evaluate the K ini Ic . Thus the suitable bilinear softening traction separation law is presented for determining the double K fracture parameters.
Calculation of the energy characteristics of a pulse-periodic electron-beam-controlled CO2laser with a cooled active mixture (1982)

The optimal excitation conditions and energy characteristics are calculated for a pulse-periodic electron-beam-controlled CO2 laser with a cooled active mixture. A comparison is made with the characteristics of electron-beam-controlled lasers operating at room temperature. It is shown that cryogenic cooling of the active mixture enables the average output power of pulse-periodic industrial electron-beam-controlled CO2 lasers to be increased by a factor of 2–3.
Optimized Laplacian Generalized Classifier Neural Network (2018)

A new variant of Generalized Classifier Neural Network (GCNN) is proposed. The traditional GCNN uses Gaussian RBF kernel where appropriate smoothing parameter is estimated using gradient descent based optimization. In this work, the Gaussian RBF kernel is replaced by Laplace kernel and optimal smoothing parameter is estimated using population-based optimization Sine Cosine Algorithm with a novel fitness function. This proposed method known as Sine Cosine Algorithm based Laplacian Generalized Classifier Neural Network (S-LGCNN). Different performance measures such as Accuracy, Specificity and F1-score are used to perform an analysis. Proposed method is tested on benchmark datasets and results are compared with other classifiers such as traditional GCNN, Logarithmic learning for GCNN, One pass learning for GCNN, probabilistic neural network and extreme learning machine. According to the test results, the proposed method can be considered an efficient way to improvise classification performance.
Featured Article: Inhibition of glutathione synthesis distinctly alters mitochondrial and cytosolic redox poise (2014)

The glutathione couple GSH/GSSG is the most abundant cellular redox buffer and is not at equilibrium among intracellular compartments. Perturbation of glutathione poise has been associated with tumorigenesis; however, due to analytical limitations, the underlying mechanisms behind this relationship are poorly understood. In this regard, we have implemented a ratiometric, genetically encoded redox-sensitive green fluorescent protein fused to human glutaredoxin (Grx1-roGFP2) to monitor real-time glutathione redox potentials in the cytosol and mitochondrial matrix of tumorigenic and non-tumorigenic cells. First, we demonstrated that recovery time in both compartments depended upon the length of exposure to oxidative challenge with diamide, a thiol-oxidizing agent. We then monitored changes in glutathione poise in cytosolic and mitochondrial matrices following inhibition of glutathione (GSH) synthesis with L-buthionine sulphoximine (BSO). The mitochondrial matrix showed higher oxidation in the BSO-treated cells indicating distinct compartmental alterations in redox poise. Finally, the contributory role of the p53 protein in supporting cytosolic redox poise was demonstrated. Inactivation of the p53 pathway by expression of a dominant-negative p53 protein sensitized the cytosol to oxidation in BSO-treated tumor cells. As a result, both compartments of PF161-T+p53(DD) cells were equally oxidized ≈20 mV by inhibition of GSH synthesis. Conversely, mitochondrial oxidation was independent of p53 status in GSH-deficient tumor cells. Taken together, these findings indicate different redox requirements for the glutathione thiol/disulfide redox couple within the cytosol and mitochondria of resting cells and reveal distinct regulation of their redox poise in response to inhibition of glutathione biosynthesis.
Origins of metabolic complications in obesity (2011)

It is essential to understand the qualitative component of lipid species involved in cellular toxicity and the molecular mechanisms mediating these toxic effects to identify new therapeutic targets.
Impact of complex wireless environments on rate adaptation algorithms (2011)

Due to the popularity of mobile computing devices, 802.11-based wireless networks have become common place. A critical but unspecified component of 802.11 is transmission rate adaptation. Rate adaptation is difficult to do because it requires accurately estimating channel conditions while experiencing distinctly different wireless phenomena such as multi-path fast fading, nodal mobility, environmental mobility and hidden terminal interference. Rate adaptation algorithms use various methods to estimate channel conditions but these methods can be inaccurate in complex wireless environments causing incorrect adaptations. In this paper, we investigate the impact of inaccurate channel estimation methods by studying two rate adaptation algorithms, CHARM and SampleRate. We emulate high fidelity versions of both algorithms, using QualNet and evaluate their performance under environmental mobility and hidden terminal interference conditions. We found that the performance of both algorithms degrade dramatically due to inaccurate estimations caused by stale channel information. We propose two optimization techniques, REGS SINR and IntRec, to counteract these inaccuracies and implement them for CHARM and SampleRate. The proposed optimization techniques increase the performance dramatically for CHARM, up to 340% for environmental mobility and more than 290% for hidden terminal interference. We saw similar improvements of 220% and 88% for SampleRate.
A phage-like bacteriocin of Rhizobium trifolii (1973)

An inducible bacteriocin produced by a strain of Rhizobium trifolii was partially purified by ammonium sulfate precipitation and differential centrifugation. Examination of fractions of this material banded in sucrose gradients showed a close correlation between bacteriocin activity and presence of phage-like particles observed by electron microscopy. The particles have a head diameter of about 50 nm and have short tails. Buoyant density of intact particles in cesium chloride was 1.46 g/cm 3 , as compared with 1.49 g/cm 3 for a reference rhizobiophage. The apparent nucleoprotein nature of the bacteriocin was confirmed by the ultraviolet absorption spectrum of CsCl-banded material. Double-stranded DNA of density 1.720 g/cm 3 (compared with 1.716 g/cm 3 for DNA of the phage) was identified in bacteriocin fractions obtained from CsCl density equilibrium gradients. This density was identical with that of DNA from both induced and noninduced bacterial cells of the producing strain. These characteristics and the inability to reproduce in sensitive bacteria identify the bactericidal agent as a large bacteriocin of the defective phage type. Some apparent differences between this bacteriocin and other, partly characterized bacteriocins of R. trifolii are discussed.
First-in-human phase I study of an oral HSP90 inhibitor, TAS-116, in advanced solid tumors. (2017)

2546 Background: TAS-116 is an oral non-ansamycin, non-purine, and non-resorcinol highly selective inhibitor of HSP90α/β. The objective of this FIH study was to determine the MTD and investigate the safety, tolerability, PK, PD (HSP70 protein levels in PBMCs), and antitumor activity of TAS-116. Methods: The study is being conducted in Japan and the UK. Patients with advanced solid tumors received escalating doses of TAS-116 once daily (QD) with an accelerated titration design. After the MTD was determined, safety and tolerability of 5 days on / 2 days off per week administration (QDx5) at the MTD in QD was explored. In parallel, the MTD with every other day administration (QOD) was evaluated by using a 3 + 3 design. Results: As of 20 September 2016, 52 patients were enrolled. TAS-116 was evaluated at doses of 4.8 to 150.5 mg/m 2 /day in the QD schedule and doses of 107.5 to 295.0 mg/m 2 /day in the QOD schedule. The MTD was 107.5 mg/m 2 /day with QD and 210.7 mg/m 2 /day with QOD. QDx5 at the MTD in QD using a flat dose of 160 mg was evaluated. The most common adverse events in all regimens were gastrointestinal disorders and increased creatinine. DLTs were observed in 4 patients in QD (night blindness, visual disorder, AST/ ALT/gamma-GTP elevations, and anorexia) and in 2 patients in QOD (platelet count decreased, febrile neutropenia, pneumonia, respiratory failure, and septic shock). Reversible eye disorders were observed in all schedules, but those observed in QDx5 were limited to grade 1. The PK level demonstrated dose proportionality without unexpected accumulation under repeated administration. Dose-related HSP70 induction of PBMCs was observed. As of 20 September 2016, three confirmed durable PRs by RECIST were observed (239 days in GIST and 173 days in NSCLC with QD; 293 + days in NSCLC with QOD). PR and SD ≥ 12 weeks were observed in 15 out of 47 patients. Conclusions: TAS-116 had an acceptable safety profile under all schedules, especially QDx5. Preliminary antitumor activity was demonstrated with evidence of target engagement. Dose expansion at the MTD in this phase 1 study and the phase 2 study in patients with GIST are ongoing. Parts of this study will be expanded to the US with an amended study protocol. Clinical trial information: NCT02965885.
Eliminating synchronization bottlenecks in object-based programs using adaptive replication (1999)

Article Free Access Share on Eliminating synchronization bottlenecks in object-based programs using adaptive replication Authors: Martin Rinard Laboratory for Computer Science, Massachusetts Institute of Technology Laboratory for Computer Science, Massachusetts Institute of TechnologyView Profile , Pedro Diniz University of Southern California, Information Sciences Institute University of Southern California, Information Sciences InstituteView Profile Authors Info & Claims ICS '99: Proceedings of the 13th international conference on SupercomputingJune 1999 Pages 83–92https://doi.org/10.1145/305138.305167Published:01 May 1999Publication History 8citation289DownloadsMetricsTotal Citations8Total Downloads289Last 12 Months7Last 6 weeks6 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Molecular Fabric Structure Formed by the 1D Coordination Polymer, [Pb(bpe)(O2CCH3)(O2CCF3)] (2007)

Crystallization of trans-1,2-bis(4-pyridyl)ethylene (bpe) with PbII acetate in the presence of CF3COOH yielded [Pb(bpe)(O2CCH3)(O2CCF3)]n, and the solid-state structure contains spiral 1D coordination polymers entangled in a “warp and weft” interwoven structure. The absence of any weak interactions between the tangled strands in the 2D sheets make this a true molecular fabric structure.
Percutaneous Coronary Intervention Using Crosswire NT in Total Occlusion of Coronary Artery (2002)

Background and Objectives:Despite marked advances in the design of percutaneous coronary intervention hardware, total occlusion remains associated with a low primary success rate. The most common cause of failure is the inability to cross the lesion with a guidewire. We report the results of a non-randomized singlecenter investigation using a hydrophilic coated guidewire (Crosswire). Subjects and Methods:We analyzed the angiographic results of 92 patients (68 males, 24 females, age 58.8±9.7 years-old) who underwent angioplasty utilizing Crosswire for either total (TIMI flow 1) or subtotal occlusion at Chonnam National University Hospital between December 2000 and July 2001. Results:Clinical diagnoses of the studied subjects revealed 40 cases of acute myocardial infarction, 15 of myocardial infarction, 29 of unstable angina and 8 of stable angina. The primary success rate was 79.3% (73/92), the success rate in total occlusion was 69.0% (40/58), and that of the chronic total occlusion cases among the total occlusion group was 64.3% (18/28). The success rates in the use of Crosswire as the first and second choice were 85.7% and 78.8%, respectively. The abrupt occlusive lesions, complex lesions more than type B2, and presence of collateral circulation were all associated with a lower success rate. Coronary artery perforation occurred in one case. Conclusion:The new nitinol hydrophilic wire, Crosswire, is a safe and effective tool for the recanalization of total occlusive coronary lesion. (Korean Circulation J 2002;32(2):125-130)
The synthesis, mesomorphic behaviour and physical properties of a chiral liquid crystal exhibiting an antiferroelectric smectici phase (1996)

Abstract A new, highly chiral liquid crystalline material exhibiting two antiferroelectric phases is reported. The material is a phenyl biphenyl carboxylate, and both the synthesis and the physical properties are described in detail. Measurements of the electro-optic switching, spontaneous polarisation, tilt angle and viscosity are presented across the entire mesophase ranges. The optical switching characteristics of the material, together with the current pulse, clearly show that the phase below the antiferroelectric chiral smectic C phase is also antiferroelectric. Physical property measurements indicate that the phase is one of the higher order smectic phases, which is identified as smectic I* by miscibility studies. It is concluded that the phase is the antiferroelectric hexatic chiral smectic I phase.
Parallel‐hierarchical neural network for 3D object recognition (2003)

Abstract In this paper, the authors propose a parallel‐hierarchical neural network that can recognize multiple 3D objects from 2D projection images. The proposed network focuses on a parallel‐hierarchical structure and memory‐based recognition assistance, which are characteristics of the excellent vision systems that living organisms have, and refers to the neocognitron, which models the parallel‐hierarchical structure of vision systems. The amount of calculations is reduced by deleting cells having a low degree of importance based on competition between cells and detecting features that differ for each cell. The network not only can recognize an object, but can also estimate its orientation at the same time. The memory‐based recognition assistance is modeled by performing iterative processing during which the input image approaches a learning image based on the orientation estimation result. Weights are determined by sequentially presenting learning images, and no teaching signal is necessary. This is done in a short time since it is not an iterative learning method. The network performance was evaluated by using five objects from COIL‐100. Images that were obtained by photographing each object after it was rotated 60° at a time around the vertical axis were used for the learning images. The experiments checked the recognition rates for various 2D projection images that were obtained from the 3D objects. These results verified the effectiveness of the proposed neural network as a 3D object recognition technique. © 2003 Wiley Periodicals, Inc. Syst Comp Jpn, 35(1): 1–12, 2004; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/scj.10579
A retrospective look at students enrolled in an upper-level horse science class: Factors that affect classroom performance1,2 (2013)

The objective of this study was to retrospectively analyze demographic variables and academic preparation of students to determine how these factors relate to student performance in ASI 521 Horse Science, an upper-level course offered in the Department of Animal Sciences and Industry (ASI) at Kansas State University (KSU). Data were collected for 264 students enrolled in the course from 2008 to 2010. Students who took the course in 2008 received greater final percentages than those who took the course in subsequent years (P = 0.0016). Females tended to receive greater percentages than males (P = 0.096). Location of origin of students did not affect percentages earned (P > 0.26). Although class standing (P = 0.35) did not affect the final percentages that students earned, transfer students received lesser final percentages in the course (P = 0.020). If students were majoring in ASI, they fared better than those in other majors (P = 0.0097), but pre-veterinary medicine students performed similarly to non-pre-veterinary students (P = 0.49). Enrollment in the equine certificate program (which requires students to complete 20 credit hours of equine coursework) did not affect percentages earned (P = 0.89) nor did completion of any individual equine class before enrolling in ASI 521 (P > 0.19). Test scores earned on the American College Testing Program standardized test during high school were not reflective of classroom performance (P = 0.51), but KSU grade point average (GPA) was highly predictive (P < 0.0001), regardless of the term for which GPA was calculated. Students in the course took an identical comprehensive test at the beginning and end of the semester, and those test scores were also predictive of final percentage earned in ASI 521 (P ≤ 0.0002). In general, students with greater GPA performed better in ASI 521, so strategies aimed at improving classroom performance may best be targeted toward students with histories of poor academic performance.
Preparation of imidazopyridinecarboxamide derivatives for use as GSK3 modulators. (2008)

Title compds. I [Q = halo; R1 = CH2NR3R4; each R2 independently = H or alkyl; R3 and R4 = together with the atoms to which they are attached form an (un)substituted heterocyclic ring contg. one or more heteroatoms selected from N, O, or S; R6 = H or alkyl; R7 = H, (un)substituted alkyl, alkylaryl, aryl, or heteroaryl], and their pharmaceutically acceptable salts, are prepd. and disclosed as glycogen synthase kinase-3 (GSK3) modulators. Thus, e.g., II•HCl was prepd. by cyclocondensation of 5-bromopyridine-2,3-diamine with terephthalic monomethyl ester followed by chlorination, iodination, sapon., amidation with morpholine, redn., and coupling with carbon monoxide and 3-methoxy-1-propanamine. I were evaluated in GSK3β scintillation proximity assays, e.g., II•HCl demonstrated an Ki value of 390 nM. [on SciFinder(R)]
Hagen, Gerd (2022)

Gerd Anna Dorothea Hagen (1928–2007) was an eminent social worker, educator, innovator, administrator, and campaigner for children’s rights in Norway. She worked tirelessly her entire professional life pioneering, developing, and promoting educational programs for child protection and social work professionals. Her creativity, enthusiasm, and leadership greatly contributed to establishing Norway’s reputation as a champion of children’s rights and well-being.
Separating Rigid Motion for continuous Shape Evolution. (2009)

A method is proposed for the construction of descent directions for the minimization of energy functionals defined for plane curves. The method is potentially useful in a number of image analysis problems, such as image registration and shape warping, where the standard gradient descent curve evolutions are not always feasible. The descent direction is constructed by taking a weighted average of the three components of the gradient corresponding to translation, rotation, and deformation. Our approach differs from previous work in the field by the use of implicit representation of curves and the notion of normal velocity of a curve evolution. Thus our theory is morphological and well suited for implementation in the level set framework.