gebhart/patrepeval huggingface dataset:
Elevated Plasma Level of Soluble F11 Receptor/Junctional Adhesion Molecule-A (F11R/JAM-A) in Hypertension (2009)

These results further support a role of F11 receptor in the pathophysiology of human hypertension.
A noble technique a using force-sensing resistor for immobilization-device quality assurance: A feasibility study (2016)

Many studies have reported that a patient can move even when an immobilization device is used. Researchers have developed an immobilization-device quality-assurance (QA) system that evaluates the validity of immobilization devices. The QA system consists of force-sensing-resistor (FSR) sensor units, an electric circuit, a signal conditioning device, and a control personal computer (PC) with in-house software. The QA system is designed to measure the force between an immobilization device and a patient’s skin by using the FSR sensor unit. This preliminary study aimed to evaluate the feasibility of using the QA system in radiation-exposure situations. When the FSR sensor unit was irradiated with a computed tomography (CT) beam and a treatment beam from a linear accelerator (LINAC), the stability of the output signal, the image artifact on the CT image, and changing the variation on the patient’s dose were tested. The results of this study demonstrate that this system is promising in that it performed within the error range (signal variation on CT beam < 0.30 kPa, root-mean-square error (RMSE) of the two CT images according to presence or absence of the FSR sensor unit < 15 HU, signal variation on the treatment beam < 0.15 kPa, and dose difference between the presence and the absence of the FSR sensor unit < 0.02%). Based on the obtained results, we will volunteer tests to investigate the clinical feasibility of the QA system.
Synthesis, Structure, and Spectroscopy of Silaallyl− and Silapentadienyl−Iridium−Phosphine Complexes (2008)

Silaallyl− and silapentadienyl−iridium−phosphine\ncomplexes have been synthesized via the reaction of “(Me)Ir(PMe&lt;sub&gt;3&lt;/sub&gt;)&lt;sub&gt;3&lt;/sub&gt;” with vinyl- and butadienyldimethylsilanes. Upon\nheating, these complexes lose methane and undergo a variety\nof reactions, including C−H bond activation to produce a five-membered iridasilacycle, CC bond coordination to generate\nan η&lt;sup&gt;1&lt;/sup&gt;,η&lt;sup&gt;2&lt;/sup&gt;-silapentadienyl ligand, and decomposition.
Human immunodeficiency virus and human papilloma virus - why HPV-induced lesions do not spontaneously resolve and why therapeutic vaccination can be successful (2009)

HIV and HPV can both cause chronic infections and are acquired during sexual contact. HIV infection results in a progressive loss of CD4+ T cells that is associated with an increased prevalence of HPV infections, type-specific persistence and an increase in HPV-associated malignancies. On the one hand this illustrates the important role of HPV-specific CD4+ helper T-cell immunity, on the other it shows the Achilles heel of the HPV-specific immune response. The use of highly active antiretroviral therapy (HAART) results in a rapid reduction of HIV and a reconstitution of systemic CD4+ T-cell levels. The use of HAART thus has the potential to raise immunity to HPV but to the surprise of many, the incidence of HPV-induced diseases has increased rather than declined since the introduction of HAART. Here, the knowledge on how HPV-induced diseases develop in the face of a non-compromised immune system will be used to explain why the effect of HAART on HPV-induced diseases is modest at best. Furthermore, exciting new data in the field of therapeutic vaccines against HPV will be discussed as this may form a more durable and clinically successful therapeutic approach for the treatment of HPV-induced high-grade lesions in HIV-positive subjects on HAART.
Long‐term aging effect on led circuit with fe‐based amorphous current transformer (1993)

Abstract The current transformer used in a conduction detector switch circuit for lighting up an light emitting diode (LED) for detection of load current in distribution lines has to be small and of low excitation current. Since field‐annealed Fe‐based amorphous cores have high saturation magnetization and the squareness ratio of a hysteresis loop and low coercive force, current transformers that are superior to ferrite cores can be designed. Furthermore, in cases where reliability is required over long periods such as in LED lighting circuits, for the purpose of design, it is necessary to predict what influence is exerted on the circuit characteristics by the aging variations of the amorphous magnetic characteristics [1, 2]. Therefore, recently, based on a prediction method of dc coercive force researched by the present authors [3], aging variation prediction was carried out on ac (60 Hz) coercive force. Next, the ac magnetic characteristics of Fe‐based amorphous cores were approximated by Potter's model [4], LED circuit analysis was carried out by application in a Spice program, and good agreement with experimental results was confirmed. In addition, using the prediction values of aging variation of the cores, on deducing the effect of influence on circuit characteristics it was found that the degradation of LED circuit characteristics at 100°C and 10 6 hours of elapse was minimal, and it is possible to predict the maintenance of excellent characteristics better than in the case of ferrite cores.
Highly Photosensitive Surface Relief Gratings Formation in a Liquid Crystalline Azobenzene Polymer:  New Implications for the Migration Process (2007)

We have recently demonstrated a markedly photosensitive surface relief gratings (SRG) formation in thin films of liquid crystalline azobenzene-containing polymers, which proceeds from a cis-rich state of the azobenzene [Zettsu et al. Adv. Mater. 2001, 13, 1693; Macromolecules 2004, 37, 8692]. Such polymers exhibited unexpected enhancements in the sensitivity to light for the completion of SRG formation, the required energy dose being ∼103-fold lower than that for other azobenzene polymers systems widely employed. Here we report detailed results on the systematic explorations for understanding the migration mechanism. The cis-isomer content at the initial state and irradiation intensity crucially influenced the migration efficiency and the resulting relief structure in nonlinear manners. The Zisman plot showed that the light irradiation leads to a large change in the critical surface tension. Such results strongly suggest that the photochemically induced phase transition and the resulting spatial modulations in the physical properties in the film play the essential roles for the SRG formation. On the basis of this knowledge, the SRG formation via a sensitized excitation was demonstrated for the first time by incorporation of a near-infrared absorbing dye.
Bioactive Organosulfur Compounds of Garlic and Garlic Products (1993)

Garlic (Allium sativum L.) and some of its derived products have well-established biological activities as antibiotics and as agents in reducing the risk factors of cardiovascular disease, and have received growing support as potential anticancer agents. However, because garlic's organosulfur compound composition varies greatly with the method of processing and because analysis of most of these compounds has only been recently achieved, there has been considerable variation in the experimental conditions, and subsequent results, in the biological studies with garlic and garlic products. This chapter discusses the importance of garlic's organosulfur compounds and the many changes that occur in their chemistry when garlic is crushed, cooked, ingested, metabolized, or commercially processed. The large variation in composition of commercial garlic products necessitates standardization of these products, especially for use in biological studies. Rapid pre-hepatic physiological changes occur to as yet undetected compounds in the blood, thus making in vitro and organ perfusion studies of limited value. The clinical studies on the cardiovascular effects of garlic preparations are summarized, and evidence is presented that low doses of allicin (allyl 2-propenethiosulfinate) and the vinyl-dithiin oils are significant blood lipid-reducing agents.
Transformation of 1,3‐Dichloropropene in Soil by Thiosulfate Fertilizers (2000)

Abstract The pesticide 1,3‐dichloropropene (1,3‐D) is considered to be the most promising alternative to methyl bromide for soilborne pest control. The high volatility of 1,3‐D, however, has been shown to result in excessive atmospheric emissions that may impose toxicological effects on workers or residents. This study demonstrated that 1,3‐D was rapidly transformed to nonvolatile products by thiosulfate fertilizers in soil, and that thiosulfate‐facilitated fumigant transformation may be used to reduce 1,3‐D emissions. Transformation of 1,3‐D by thiosulfate was chemically based, and 1,3‐D degradation in soil accelerated proportionally as thiosulfate level in soil increased. At a 4:1 thiosulfate to fumigant molar ratio, the half‐life of 1,3‐D was reduced to only a few hours, as compared with &gt;10 d for nonamended soils. The rate of thiosulfate‐facilitated 1,3‐D transformation was independent of soil types and was higher in moist soils and at high soil temperatures. Transformation occurred at a similar rate for ammonium, calcium, and sodium thiosulfates. As these thiosulfate compounds are commercial fertilizers, amendment of these products at the soil surface during 1,3‐D fumigation may offer an effective and inexpensive approach for reducing 1,3‐D emissions.
Gliese 569B: A Young Multiple Brown Dwarf System? (2001)

The nearby late M star Gliese 569B was recently found by adaptive optics imaging to be a double with separation ~1 AU. To explore the orbital motion and masses, we have undertaken a high resolution (~0.05 arcsec) astrometric study. Images were obtained over 1.5 years with bispectrum speckle interferometry at the 6.5m MMT and 6m SAO telescopes. Our data show motion corresponding to more than half the orbital period, and constrain the total mass to be > 0.115 M_solar, with a most probable value of 0.145 M_solar. Higher masses cannot be excluded without more extended observations, but from statistical analysis we find an 80% probability that the total mass is less than 0.21 M_solar. An infrared spectrum of the blended B double obtained with the MMT has been modeled as a blend of two different spectral types, chosen to be consistent with the measured J and K band brightness difference of a factor ~2. The blended fit is not nearly as good as that to a pure M8.5+ template. Therefore we hypothesize that the brighter component likely has two unresolved components with near equal masses, each the same as the fainter component. If Gl 569B is a triple our dynamical limits suggest each component has a mass of 50 (+23/-4) M_jupiter. We infer an age for the system of 300 Myr, from its kinematic motion which places its as a member of the Ursa Major moving group. All the above parameters are consistent with the latest DUSTY evolutiuon models for brown dwarfs.
Dependence of the activity of beef heart mitochondrial ATPase on the properties of the catalytic metal ion (1987)

Several divalent metal ions were used as kinetic probes of the beef heart mitochondrial adenosinetriphosphatase (F1) under a variety of conditions, and the relationship between the properties of the catalytic metal ion and the catalytic activity of the enzyme was examined. Vmax for ATP hydrolysis was largest when metal ions characterized by intermediate values of acidity of coordinated water molecules (pKa) and metal-nucleotide stability constants (Kstab) were present. As temperature increased, the peak of Vmax vs. pKa (or Kstab) shifted to lower initial values of pKa or Kstab. The solvent deuterium isotope effect on Vmax (DV) was normal and largest when the metal ion present during F1-catalyzed ATP hydrolysis was most acidic and the metal nucleotide stability constant was large. When an active site tyrosine on F1 was nitrated, Vmax was most affected when the metal ion present was least acidic and the metal nucleotide stability constant was small. The isotope effect on V/K (DV/K) was normal, small, and apparently independent of the metal ion present. ADP inhibition of F1-catalyzed ATP hydrolysis is competitive, and the Ki is independent of the metal ion present. The degree of Pi inhibition of F1 is dependent on the metal ion present. The inhibition by Pi is competitive at low temperature and becomes noncompetitive as temperature increases. These and previous results support a mechanism whereby a water molecule coordinated to the metal ion of an enzyme-bound gamma-monodentate metal-ATP complex is deprotonated to begin a series of events whereby a beta,gamma-bidentate metal-ATP complex is produced. Upon hydrolysis, the bond between the metal ion and the beta-phosphate of ADP in the Pi-metal-ADP complex is broken before products (ADP and metal-Pi) are released.
Brain Slice Stimulation Using a Microfluidic Network and Standard Perfusion Chamber (2007)

We have demonstrated the fabrication of a two-level microfluidic device that can be easily integrated with existing electrophysiology setups. The two-level microfluidic device is fabricated using a two-step standard negative resist lithography process 1. The first level contains microchannels with inlet and outlet ports at each end. The second level contains microscale circular holes located midway of the channel length and centered along with channel width. Passive pumping method is used to pump fluids from the inlet port to the outlet port 2. The microfluidic device is integrated with off-the-shelf perfusion chambers and allows seamless integration with the electrophysiology setup. The fluids introduced at the inlet ports flow through the microchannels towards the outlet ports and also escape through the circular openings located on top of the microchannels into the bath of the perfusion. Thus the bottom surface of the brain slice placed in the perfusion chamber bath and above the microfluidic device can be exposed with different neurotransmitters. The microscale thickness of the microfluidic device and the transparent nature of the materials [glass coverslip and PDMS (polydimethylsiloxane)] used to make the microfluidic device allow microscopy of the brain slice. The microfluidic device allows modulation (both spatial and temporal) of the chemical stimuli introduced to the brain slice microenvironments.
Effect of Macro-Cyclic Bifunctional Chelators DOTA and NODAGA on Radiolabeling and In Vivo Biodistribution of Ga-68 Cyclic RGD Dimer (2019)

<b><i>Introduction:</i></b> The advent of the Germanium-68 (Ge-68)/Gallium-68 (Ga-68) generator has contributed enormously to a plethora of molecular imaging approaches for <i>in vivo</i> identification of tumor characteristics. The present study compares the effect of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and 1,4,7-triazacyclononane,1-gluteric acid-4,7-acetic acid (NODAGA) bifunctional chelators on radiolabeling of arginine-glycine-aspartic acid (RGD) dimer, an antagonist of integrin α<sub>v</sub>β<sub>3</sub> with Ga-68 and their biodistribution in C57BL/6 mice bearing melanoma and in patients with breast carcinoma. <b><i>Methods:</i></b> Radiolabeling parameters for DOTA-(RGD)<sub>2</sub> and NODAGA-(RGD)<sub>2</sub> with Ga-68 were optimized in-house. After quality control procedures, preclinical studies were done in C57BL/6 mice bearing melanoma. The percent radioactivity associated with per gram of various organs and tumor (% ID/g) was analyzed. Positron emission tomography-computed tomography patient imaging was performed in clinically diagnosed locally advanced breast carcinoma patients (<i>n</i> = 30). The uptake of various organs and lesions for both radiotracers was compared. <b><i>Results:</i></b> Radiolabeling yield >95% was obtained by heating 15-20 μg of peptide at 95°C for 5-10 min and 3.5-4.0 reaction pH. NODAGA-(RGD)<sub>2</sub> could also be radiolabeled at room temperature, but 40-50 μg peptide was required. Animal biodistribution study revealed the kidney as the major excretory organ for both the radiotracers. Maximum counts were observed in tumor at 45 min. During the clinical study, liver, spleen, bilateral brain ventricles, salivary glands, and intestines were the organs with physiological uptake of both Ga-68-DOTA-(RGD)<sub>2</sub> and Ga-68 NODAGA-(RGD)<sub>2</sub>. The major excretory route was through kidneys. All primary lesions were picked by both the radiotracers. Additionally, in 5 patients, metastatic lesions were also picked up. <b><i>Conclusion:</i></b> DOTA- and NODAGA-chelated RGD<sub>2</sub> were successfully radiolabeled with Ga-68. Good tumor to background contrast exhibited by Ga-68-DOTA-(RGD)<sub>2</sub> and Ga-68 NODAGA-(RGD)<sub>2</sub> in both preclinical and clinical studies suggested that both radiotracers can be used as potential molecular tools for imaging angiogenesis.
Identification of 2, 3-Octanediol, 2-Hydroxy-3-octanone and 3-Hydroxy-2-octanone from Male Xylotrechus chinensis CHEVROLAT as Possible Sex Pheromones (Coleoptera : Cerambycidae) (1987)

In the extract of field-collected male cerambycid beetles Xylotrechus chinensis CHEVROLAT, three components were found as male-characteristic scent principles by gas liquid chromatography (GLC). Their chemical structures were identified as 2, 3-octanediol, 2-hydroxy-3-octanone and 3-hydroxy-2-octanone, by comparison of their GLC retention times with those of authentic compounds using a fused silica capillary column and also comparison of their mass fragmentation patterns derived from a capillary GC/MS with authentic compounds.
[Lewis Acid]+[Co(CO)4]− Complexes: A Versatile Class of Catalysts for Carbonylative Ring Expansion of Epoxides and Aziridines (2002)

Mit Lewis-Säuren zu β-Lactonen und β-Lactamen: Mit Komplexen des Typs [Lewis-Säure]+[Co(CO)4]−, z. B. 1 und 2, lässt sich in die C-O- und die C-N-Bindung von Epoxiden und Aziridinen effizient, stereoselektiv und unter milden Bedingungen eine Carbonylgruppe inserieren, wobei β-Lactone bzw. β-Lactame entstehen. Merkmal beider mechanistisch gleichen Reaktionen ist die Konfigurationsumkehr an der Position der CO-Insertion. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2002/z18813_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Importance Sampling Microfacet‐Based BSDFs using the Distribution of Visible Normals (2014)

Abstract We present a new approach to microfacet‐based BSDF importance sampling. Previously proposed sampling schemes for popular analytic BSDFs typically begin by choosing a microfacet normal at random in a way that is independent of direction of incident light. To sample the full BSDF using these normals requires arbitrarily large sample weights leading to possible fireflies. Additionally, at grazing angles nearly half of the sampled normals face away from the incident ray and must be rejected, making the sampling scheme inefficient. Instead, we show how to use the distribution of visible normals directly to generate samples, where normals are weighted by their projection factor toward the incident direction. In this way, no backfacing normals are sampled and the sample weights contain only the shadowing factor of outgoing rays (and additionally a Fresnel term for conductors). Arbitrarily large sample weights are avoided and variance is reduced. Since the BSDF depends on the microsurface model, we describe our sampling algorithm for two models: the V‐cavity and the Smith models. We demonstrate results for both isotropic and anisotropic rough conductors and dielectrics with Beckmann and GGX distributions.
A novel method for solvent fractionation of two CLA isomers (2006)

Abstract Conjugated linoleic acid (CLA) is commercially available as a mixture consisting of almost equal amounts of the cis ‐9,trans‐11‐CLA ( c9 , t 11) and trans ‐10, cis ‐12‐CLA ( t 10, c 12) isomers. Separation of the two isomers is highly significant since each exhibits different biochemical properties. Highly efficient separation could be accomplished by crystallization in acetone (solvent) of the two CLA isomers (solutes) in the presence of medium‐chain fatty‐acid (MCFA) additives. The relative concentration ratios of the two CLA isomers in the solvent‐crystallized materials varied depending on which MCFA were added. Addition of lauric and decanoic acids resulted in the crystals predominantly containing t 10, c 12, whereas octanoic acid yielded those predominantly containing c 9, t 11. We have confirmed that onetime solvent crystallization using decanoic acid and octanoic acid additives increased the t 10, c 12 and c 9, t 11 concentrations, and that repeated solvent crystallization resulted in the ratio of c 9, t 11 to t 10, c 12 of at least 4∶96 or 98∶2.
Elastase and Cathepsin G from Primed Leukocytes Cleave Vascular Endothelial Cadherin in Hemodialysis Patients (2014)

Elastase and cathepsin G are elevated in the plasma of HD patients, originating from primed PMNLs. In these patients, chronic elevation of these enzymes contributes to cleavage of VE-cadherin and possible disruption of endothelial integrity.
Light Source Estimation with Analytical Path-tracing (2017)

We present a novel algorithm for light source estimation in scenes reconstructed with a RGB-D camera based on an analytically-derived formulation of path-tracing. Our algorithm traces the reconstructed scene with a custom path-tracer and computes the analytical derivatives of the light transport equation from principles in optics. These derivatives are then used to perform gradient descent, minimizing the photometric error between one or more captured reference images and renders of our current lighting estimation using an environment map parameterization for light sources. We show that our approach of modeling all light sources as points at infinity approximates lights located near the scene with surprising accuracy. Due to the analytical formulation of derivatives, optimization to the solution is considerably accelerated. We verify our algorithm using both real and synthetic data.
A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-κB-regulated promoters (2004)

Glucocorticoid receptor (GR)-mediated transrepression of the transcription factors AP-1 and NF-kappaB, responsible for most of the anti-inflammatory effects of glucocorticoids, is initiated by the tethering of GR to the promoters of target genes. We report that this tethering is mediated by a nuclear isoform of the focal adhesion LIM domain protein Trip6. Trip6 functions as a coactivator for both AP-1 and NF-kappaB. As shown by chromatin immunoprecipitation, Trip6 is recruited to the promoters of target genes together with AP-1 or NF-kappaB. In the presence of glucocorticoids, GR joins the Trip6 complex. Reducing the level of Trip6 by RNA interference or abolishing its interaction with GR by dominant-negative mutation eliminates transrepression. We propose that GR tethering to the target promoter through Trip6 forms the basis of transrepression, and that Trip6 exerts its nuclear functions by acting as a molecular platform, enabling target promoters to integrate activating or repressing signals.