gebhart/patrepeval huggingface dataset:
Leptin Signaling Modulates Expression of Polycomb and Trithorax Complexes in the Brain of Fat Tissue Implanted Polycystic Ovarian Sindrome Mice (2014)

The Polycystic Ovary Syndrome (PCOS) is the most common androgenic disorder in women during reproductive life. PCOS may also be accompanied by metabolic syndrome and recent studies point to leptin as playing a role in disrupting infertility and in changing the energy balance in obese mice through its action on the hypothalamus. The aim is to assess the expression of the Polycomb & Trithorax Complexes genes in brain of mice transplanted with fat tissue from normal mice, in order to better understand the neuronal mechanisms underlying the reversion of PCOS. Three B6 V-Lepob/J mouse groups: Normal weight, obese and seven-day-treatment obese had their brain RNA extracted and submitted to an 84 Polycomb & Trithorax Complexes genes PCR Array plate and MetacoreTM pathways localization. Genomic profiles obtained were compared to the ones of the normal-weight-mice group. Differentially expressed genes were 13% and 26% respectively to control and treatment. Major changes were in genes: Snai1/31; Smarca1/?17; Dnmt3b/4.7; Ezh1/ 15. Altered genes were associated to canonical pathways and provided 3 networks related to epigenetics. Underlying neuronal changes caused by leptin in obese mice brain, there is an important role being played by the histone code. Here there is evidence that leptin drives the chromatin packing to a more condensed pattern. Upregulation of methyltransferase genes, like Ezh1, favors this thought. In summary the Polycomb & Trithorax complexes might answer for the silencing of some downregulated genes in the obese mice brain when exposed to leptin.
Bandwidth and Sensitivity Enhancement of Piezoelectric MEMS Acoustic Emission Sensor Using Multi-Cantilevers (2022)

The bandwidth and sensitivity of piezoelectric MEMS acoustic emission (AE) sensors are enhanced using multi-cantilevers that are electrically connected in series. Compared with a single-cantilever sensor, the bandwidth and sensitivity are increased 5.3- and 2- fold, respectively, by using an array of 210 cantilevers. By optimizing the silicon-layer thickness, the sensitivity of the single-cantilever sensor can be improved 6- fold. As a result, even a smaller array of 10 cantilevers with the optimized layer thicknesses exhibits 2-fold enhancement of bandwidth and 4-fold enhancement of sensitivity. The AE-wave detection capability is demonstrated by the standard pencil-lead break test.
Lavage type III procollagen N-terminal peptides in human pulmonary fibrosis and sarcoidosis. (1983)

Levels of type III procollagen N-terminal peptide were immunoassayed in sera and bronchoalveolar lavage fluids from healthy volunteers and patients with idiopathic pulmonary fibrosis or sarcoidosis. Peptide levels normalized to protein were higher than corresponding serum levels in all groups, suggesting that the lung is a producer of this peptide. Levels were significantly elevated in both patient groups, suggesting increased rates of type III collagen synthesis. Values were highest in idiopathic pulmonary fibrosis samples. Correlation of peptide levels with clinical severity of disease and lavage cell profiles was poor, perhaps because the latter reflects aspects of the disease process other than that stage in which type III collagen synthesis is altered. Lavage analyses of procollagen peptides may provide an important index of altered collagen synthesis in interstitial lung disease.
A Proposal of Portfolio Choice for Infinitely Divisible Distributions of Assets Returns (2008)

In the paper we present a proposal of augmenting portfolio analysis for the infinitely divisible distributions of returns - so that the prices of assets can follow Lévy processes. In this article we propose a model in which asset prices follow multidimensional Lévy process and the interdependence between assets are described by covariance and multidimensional jump measure. Then we propose to choose the optimal portfolio based on three criteria: mean return, total variance of diffusion and a measure of jump risk. We also consider augmenting this multi-criteria choice setup for the costs of possible portfolio adjustments.
MEASUREMENT OF CONTACT POTENTIAL DIFFERENCES BY ELECTRON INTERFEROMETRY (1964)

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[Drug therapy of migraine]. (1988)

Out of the knowledge of various headache syndromes the physician has to develop a clear diagnostical and therapeutical concept. This is especially true for migraine. Relevant pathophysiological hypotheses are presented e.g. the neurogenic-vascular model of migraine. Metoclopramide and domperidone in combination with mono-analgesics, ergotamine and nonsteroidal-antiinflammatory drugs are favoured in the treatment of the acute migraine attack. 2 to 4 mg ergotamine for the attack, respectively 16 to 20 mg per month should not be exceeded. Mixed compounds, containing ergots, analgesics, codeine, caffeine, tranquilizers and barbiturates should be avoided as these drugs may induce rebound-headache. A prophylaxis of migraine is indicated if a migraineur suffers from at least 2 attacks per month or if a migraine attack lasts longer than 4 days. In the first place, beta-blockers and flunarizine, in some cases verapamil or naproxen, should be used; the effect of dihydroergotamine is questionable. Because of its severe side effects, methysergide should only be given if all other prophylactic drugs fail. Naproxen is standard medication in the short time prophylaxis of menstrual migraine.
Propionyl-CoA carboxylase inNocardia mediterranei (1984)

The propionyl-CoA carboxylase activity of crude extracts of Nocardia mediterranei fractionated by ammonium sulfate (40-60%) is described.Such an enzyme may play an important role in the biosynthesis of rifamycin as well as in the degradation of various amino acids.The effect of different compounds on the enzymatic reaction have been investigated.Product P8/1-OG and citrate inhibited the enzyme.An activation by the amino acids isoleucine, methionine, threonine and valine was found.The results do not exclude that the same enzyme is responsible for the carboxylation of acetyl-CoA and propionyl-CoA.
The concurrent maturation of mouse and human thymocytes in human fetal thymus implanted in NIH-beige-nude-xid mice is associated with the reconstitution of the murine immune system. (1993)

To determine whether the human thymus provides an environment for the maturation of murine T cells, human fetal thymus and liver (hu-thy/liv) were implanted into congenitally athymic NIH-beige-nude-xid (BNX) mice or C.B-17 scid/scid (SCID) mice. 3 mo after implantation, in contrast to the hu-thy/liv implant in SCID mice, which was populated only with human CD4/CD8 single- and double-positive thymocytes, the hu-thy/liv implant in BNX mice contained a chimeric population of human and mouse CD4/CD8 single- and double-positive thymocytes. Immunohistochemical staining of the hu-thy/liv implant in BNX mice indicated that the population of double-positive mouse thymocytes was localized to discrete areas of the human fetal thymus. Quantitative improvements in mouse T cell and immunoglobulin (Ig) G parameters were observed after grafting of the human fetal thymus and liver tissue into BNX mice. In addition, in contrast to the nonimplanted BNX mice, the implanted BNX mice were capable of mounting a keyhole limpet hemocyanin-specific IgG response and their peripheral T cells were responsive to stimulation with mitogens and antibodies directed to the T cell receptor. Furthermore, after in vivo priming, T cells present in lymph nodes of the implanted BNX mice were capable of mounting an antigen-induced in vitro T cell-dependent proliferative response. Thus, concurrent with the continued maturation of human T cells, murine T cells differentiated within the human fetal thymus implanted in the BNX mice and mediated the phenotypic and functional reconstitution of the murine immune system. Mice with a reconstituted immune system that contain a human thymic implant that is infectible with human immunodeficiency virus (HIV) should prove useful in the investigation of T cell maturation in the thymus and in the evaluation of potential HIV vaccines.
1-Octen-3-ol – the attractant that repels (2015)

Since the discovery in the early 1980s that 1-octen-3-ol, isolated from oxen breath, attracts tsetse fly, there has been growing interest in exploring the use of this semiochemical as a possible generic lure for trapping host-seeking mosquitoes. Intriguingly, traps baited with 1-octen-3-ol captured significantly more females of the malaria mosquito, Anopheles gambiae, and the yellow fever mosquito, Aedes aegypti, than control traps, but failed to attract the southern house mosquito, Culex quinquefasciatus. Additionally, it has been demonstrated that this attractant is detected with enantioselective odorant receptors (ORs) expressed only in maxillary palps. On the basis of indoor behavioral assays it has even been suggested that 1-octen-3-ol might be a repellent to the southern house mosquito. Our approach was two-prong, i.e., to isolate 1-octen-3-ol-sensitive ORs expressed in maxillary palps and antennae of southern house female mosquito, and test the hypothesis that this semiochemical is a repellent. An OR with high transcript levels in maxillary palps, CquiOR118b, showed remarkable selectivity towards ( R)-1-octen-3-ol, whereas an OR expressed in antennae, CquiOR114b, showed higher preference for ( S)-1-octen-3-ol than its antipode. Repellency by a surface landing and feeding assay showed that not only racemic, but enantiopure ( R)- and ( S)-1-octen-3-ol are repellents at 1% dose thus suggesting the occurrence of other ( S)-1-octen-3-ol-sensitive OR(s). Female mosquitoes with ablated maxillary palps were repelled by 1-octen-3-ol, which implies that in addition to OR(s) in the maxillary palps, antennal OR(s) are essential for repellency activity.
Soil management for sustainable food production in Taiwan (1994)

Under Taiwan’s subtropical conditions and intensive cropping systems, soils suffer from a low pH, and a low organic matter and nutrient content. Chemical fertilizers are used to increase crop production, and good yields have been obtained in past years. However, other soil properties such as low pH, low organic matter content and poor drainage are not being treated by farmers, and are becoming an obstacle to soil productivity. Soil management strategies such as liming, fertilizer recommendations based on soil testing and plant analysis, crop rotation, breaking the hard-pan, and the application of organic materials and biofertilizer are being adopted for sustainable agricultural production in Taiwan.
Vascular Anomalies of the Fundus Oculi: Diagnosis and Treatment (2012)

Vascular anomalies of the fundus oculi represent a heterogeneous group of diseases, which includes sickle-cell retinopathy, hypertension, coats’ disease, parafoveal (juxtafoveal) retinal telangiectasia, retinal arterial macroaneurysm, retinal capillary hemangioma, Eales’ disease, and ocular ischemic syndrome. This chapter discusses the diagnosis and treatment of vascular anomalies of the fundus.
Interferometric four-wave-mixing spectroscopy on bulk GaAs (1997)

A phenomenon in interferometric four-wave mixing is reported which can be used to quantify effects beyond the third-order perturbational limit in a sensitive and intuitive fashion. The experiments on bulk GaAs at T=77 K on a time scale of 10 fs and at excited carrier densities as low as 2.3\ifmmode\times\else\texttimes\fi{}${10}^{14}$${\mathrm{ncm}}^{\mathrm{\ensuremath{-}}3}$ show that the third- order perturbational limit can hardly be reached experimentally.
Optimising time samples for determining area under the curve of pharmacokinetic data using non-compartmental analysis (2019)

The creation of the algorithm and its companion web application allows users with limited pharmacometric or programming training can obtain optimal sampling times for pharmacokinetic studies.
Distributed query optimization by one-shot fixed-precision semi-join execution (2002)

A novel semijoin execution strategy is proposed which allows parallelism and processes multiple semijoins simultaneously. In practice most of the parameters needed for query optimization, such as relation cardinality and selectivity, are of fixed-precision. Imposing this fixed-precision constraint, an efficient distributed query processing algorithm is developed. For situations where the fixed-precision constraint does not apply, a method to truncate the parameters and to use the same algorithm to find near-optimal solutions is proposed. By analyzing the truncation errors, a quantitative comparison between the near-optimal solutions and the optimal ones is provided.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Treatment of acute appendicitis in France by type of hospital: Patient profiles are different but practices and results are the same, a prospective cohort study of 1241 patients (2021)

In this prospective observational study we compared patient characteristics, surgical practices and results, according to the type of hospital to which patients with acute appendicitis were admitted. We extracted data concerning all adults in the French Surgical Association's Multicenter register of patients admitted to emergency or surgical units for acute appendicitis (APPEA) over 4 months in 2016. The APPEA database included 1241 adults. 806 patients (64.9%) were admitted to a University Hospital (UH), 337 (27.2%) to a Regional Hospital (RH) and 98 (7.9%) to Private Clinics (PC). RH admitted significantly older patients (median age 35 [25–53], p=.008) and a higher percentage of obese patients (55 (17.9%) p< .001) than UH (median age 30 [23–45], BMI ≥30: 54 (8.4%)) and PC (median age 33.5 [24–54], BMI ≥30: 9 (10.7%)). Only 17 (1.4%) patients underwent surgery without any preoperative imaging examination. Laparoscopy was significantly more frequent in PC (94.9%) and UH (94.2%) than in RH (86.9%) (p ≤ 0.001). Thirty-day overall mortality (0.24%)) and morbidity (8.2%) were not significantly related to the type of hospital. The median length of hospital stay was longer in RH than in UH: 69 h [45–106] vs 48 [24–96] respectively, (p ≤ 0.001). We observed a significant difference in the characteristics of patients operated on for appendicitis between different types of hospital, and some low inhomogeneity of practices. Nevertheless results in terms of morbi-mortality were comparable with a low rate of morbimortality, allowing future higher proportion of outpatient procedures regardless of the type of hospital.
A method for estimating rain rate and drop size distribution from polarimetric radar measurements (2002)

Since the idea of differential reflectivity was first proposed the polarimetric radar technique has attracted great attention. Polarization radar measurements such as radar reflectivity (Z/sub HH/), differential reflectivity (Z/sub DR/) specific differential phase shift (K/sub DP/), and linear de-polarization ratio (LDR) have been successfully measured. These polarimetric measurements provide more information about precipitation and allow better characterization of hydrometeors. Z/sub DR/ and K/sub DP/ contain drop size information. Rain rate estimation from radar measurements is based on empirical models such as the Z-R relation, R(Z,Z/sub Dr/) and R(K/sub DP/). The empirical relations cannot give accurate results of estimation for various types of rain and drop size distribution (DSD). Accurate rain rate estimation requires detailed knowledge of rain DSD. In the past, rain DSD was commonly assumed to be an exponential distribution. Some observations, however, indicate that natural rain DSD contains fewer of both very large and very small drops than exponential distribution. The Gamma DSD with three parameters is capable of describing a broader variation in raindrop size distribution than an exponential distribution. The problem is how to retrieve the three parameters from limited radar measurements. The authors propose a method for retrieving DSD parameters and use them to calculate rain rate and the characteristic size.
Mesomorphic Structure of Poly(styrene)-block-poly(4-vinylpyridine) with Oligo(ethylene oxide)sulfonic Acid Side Chains as a Model for Molecularly Reinforced Polymer Electrolyte (2002)

We report self-organized polymer electrolytes based on poly(styrene)-block-poly(4-vinylpyridine) (PS-block-P4VP). Liquidlike ethylene oxide (EO) oligomers with sulfonic acid end groups are bonded to the P4VP block, leading to comb-shaped supramolecules with the PS-block-P4VP backbone. Lithium perchlorate (LiClO4) has been added to the EO-rich domains. Small- and wide-angle X-ray scattering in combination with Fourier transformation infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), ac impedance, and dynamic mechanical spectroscopy (DMA) suggests alternating lamellae of reinforcing glassy PS domains and ionically conducting “nanochannels” consisting of poly(4-vinylpyridinium), oligomeric ethylene oxide sulfonates, and LiClO4. The long period of the self-organization is ca. 300 Å. So far, the ionic conductivity levels remained relatively low, i.e., 10-7−10-6 S/cm at room temperature and 10-5−10-4 S/cm at 80 °C. However, as self-organization of polymeric supramolecules allows combining glassy reinforcing domains and well-plasticized domains consisting of oligomers with high segmental motions, there may exist possibilities to tune feasible combination of electrical and mechanical properties.
Apatite‐forming ability of a zirconia/alumina nano‐composite induced by chemical treatment (2002)

Induction of an apatite-forming ability on a nano-composite of a ceria-stabilized tetragonal zirconia polycrystals (Ce-TZP) and alumina (Al2O3) polycrystals via chemical treatment with aqueous solutions of H3PO4, H2SO4, HCl, or NaOH has been investigated. The Ce-TZP/Al2O3 composite is attractive as a load-bearing bone substitute because of its mechanical properties. The chemical treatments produced Zr-OH surface functional groups, which are known to be effective for apatite nucleation in a body environment. The composite, after chemical treatment, was shown to form a bonelike apatite layer when immersed in a simulated body fluid containing ion concentrations nearly equal to those in human blood plasma. This implies that it may form apatite in the living body and bond to living bone through the apatite layer. This type of bioactive Ce-TZP/Al2O3 composite is therefore expected to be useful as a bone substitute, even under load-bearing conditions.
Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell proliferation, cause DNA double-strand break and trigger caspase-mediated apoptosis through JNK/p38 pathways in human acute promyelocytic leukemia cells (2019)

Ruthenium(II) complexes with 6-methyl-2-thiouracil cis-[Ru(6m2tu)<sub>2</sub>(PPh<sub>3</sub>)<sub>2</sub>] (1) and [Ru(6m2tu)<sub>2</sub>(dppb)] (2) (where PPh<sub>3 = </sub>triphenylphosphine; dppb = 1,4-bis(diphenylphosphino)butane; and 6m2tu = 6-methyl-2-thiouracil) are potent cytotoxic agents and able to bind DNA. The aim of this study was to evaluate in vitro cellular underlying mechanism and in vivo effectiveness of these ruthenium(II) complexes in human acute promyelocytic leukemia HL-60 cells. Both complexes displayed potent and selective cytotoxicity in myeloid leukemia cell lines, and were detected into HL-60 cells. Reduction of the cell proliferation and augmented phosphatidylserine externalization, caspase-3, -8 and -9 activation and loss of mitochondrial transmembrane potential were observed in HL-60 cells treated with both complexes. Cotreatment with Z-VAD(OMe)-FMK, a pan-caspase inhibitor, reduced Ru(II) complexes-induced apoptosis. In addition, both metal complexes induced phosphorylation of histone H2AX (S139), JNK2 (T183/Y185) and p38α (T180/Y182), and cotreatment with JNK/SAPK and p38 MAPK inhibitors reduced complexes-induced apoptosis, indicating DNA double-strand break and activation of caspase-mediated apoptosis through JNK/p38 pathways. Complex 1 also reduced HL-60 cell growth in xenograft model. Overall, the outcome indicated the ruthenium(II) complexes with 6-methyl-2-thiouracil as a novel promising antileukemic drug candidates.
Summary of the evidence file demonstrating completion of the NIF Project Completion Criteria (2014)

This document summarizes the results of performance verification tests on NIF that demonstrate it has met its performance-related Project Completion Criteria (PCC). It includes measurements made on NIF with the NIF diagnostics, the calibration of these diagnostics and the supporting analyses that verify the NIF performance criteria have been met.
Role of Intraoperative Skeletal Scintigraphy in the Localization of Osteoblastomas (2000)

Osteoblastoma is a rare neoplasm that accounts for 1% of all primary bone tumors. It is histologically benign but locally aggressive and has a high tendency to recur if it is not resected completely. A case illustrating the use of intraoperative skeletal scintigraphy to facilitate complete removal of a recurrent aggressive osteoblastoma of L5 is presented.
Mathematical modeling of venous ulcer healing rates after implantation of keratinocytes: New ways to predict the efficacy of wound healing after regenerative methods (2010)

The treatment of patients with leg ulcers is both time consuming as well as costly. We found predictable and objective parameters with a mathematical model, which will help to assess wound healing in an individual. The basic principle of our mathematic model is that cells of the neoepithelium are under the influence of different stress factors. We identified correlations between the parameters of our equation and the ulcer area and ulcer duration, based on wound size reduction by a new epithelial layer, and we estimated the survival rates of the transplanted keratinocytes. Our model is consistent with our clinical data and seems applicable for analogous situations, e.g., transplantations of cells to wounds. By this method, we are able to compare qualitatively different treatments and different materials for wound healing even in small groups of patients in an objective way.
PHASE VOLUME CHANGES ACCOMPANYING WATER EXTRACTION FROM AQUEOUS ELECTROLYTE SOLUTIONS BY 1-OCTANOL (1995)

ABSTRACT The extraction of water by 1-octanol was calculated as a function of aqueous electrolyte concentration and initial O/ volume ratio for a series of representative salts, including LiC1, NaC1, KC1, NaNO3, NaCIO4, MgCl2, and CaCl2 These results were then used to calculate the resultant phase-volume changes and aqueous-electrolyte-concentration changes. Such corrections are necessitated for precise extraction measurements employing 1-octanol as a diluent, especially as the O/A phase ratio exceeds unity.
Effect of a conjugate of daunomycin and antibodies to rat alpha-fetoprotein on the growth of alpha-fetoprotein-producing tumor cells. (1982)

Daunomycin was covalently attached via a dextran bridge to specific antibodies against rat alpha-fetoprotein produced in a horse. The effect of this conjugate on an alpha-fetoprotein-producing tumor was investigated in terms of cytotoxicity and inhibition or retardation of tumor development. Under the experimental conditions used, the covalent conjugate was by both criteria more efficient than either daunomycin alone or a mixture of daunomycin and specific antibodies or a conjugate of daunomycin with horse immunoglobulin. These results show that the conjugate may be useful as a specific cytotoxic agent against alpha-fetoprotein-producing tumors.
Evaluation of different wavelet constructions (designs) for analysis of protein sequences (2003)

We have shown previously that digital signal processing methods and in particular wavelets can be used to analyze linear sequences of amino acids to reveal the informational content of proteins. In addition, we have shown that Morlet wavelets are the most suitable for the identification of active sites within the protein sequence. Here, we modify the Morlet function to optimise it for the use in protein analysis.