gebhart/patrepeval huggingface dataset:
Reactive Astrocytes as Potential Manipulation Targets in Novel Cell Replacement Therapy of Parkinsons Disease (2005)

Parkinson' disease (PD) is a most common and debilitating degenerative disease resulted from massive loss of dopamine neurons in the substantia nigra pars compacta, which is characterized by severe motor symptoms of tremor, bradykinesia, rigidity and postural instability. Protection of nigral dopamine neurons from progressive degenerative death and cell replacement of novel dopamine neurons are hopeful strategies against PD in humans. The reactive astrocytes or functional activation of astrocytes abundantly occurred in brain insults including trauma, ischemia, and 6-OHDA or MPTP-treated PD animal models. Although they were traditionally assumed to impede neuronal regeneration by forming glial scars, growing evidence has indicated that reactive astrocytes do offer crucial benefits in functional recovery of brain injuries. The reactive astrocytes can produce various neurotrophic factors for neuron survival, synthesize extracellular substrates for axonal outgrowth and synaptogenesis, act as scavengers for free radical and excess glutamate, and promote neurogenesis of neural progenitor cells in the adult brains. We thereafter hypothesize that reactive astrocytes may also play important roles in the protection of nigral dopamine neurons or transplanted dopamine cells through their neurotrophic functions and active interaction with dopamine neurons or neural progenitor cells. Future approaches deserve to target on neurotrophic functions of reactive astrocytes in the basal ganglia and interventions to facilitate survival and axonal regeneration of dopamine neurons or differentiation of dopamine progenitor cells. Novel pharmaceutical and cell replacement strategies will hopefully be developed by potential manipulation of reactive astrocytes in the basal ganglia in prevention and treatment of Parkinson's disease.
A single-degree-of-freedom approach to response perturbation due to feature variability (1999)

This paper presents a technique to assess the impact on model predictions due to feature perturbations on harmonically forced fluid-loaded structural acoustic models. The perspective taken is one of knowledge of a reference state, with a desire to determine the impact on the total radiated acoustic power due to perturbations in the reference state. Such perturbations change the predicted resonance frequencies of a structure under consideration, and hence, change the predicted response amplitudes. The method uses a single-degree-of-freedom response model in the local region of each fluid-loaded resonance, coupled with eigenvalue sensitivities, to estimate the perturbation impact. The sensitivity of the eigenvalues to changes in model detail is derived based on variations in the spatial representation of attached features (e.g., point versus distributed attachments). Elements of the analysis method are not necessarily restricted to model perturbations nor acoustic power, rather they may be used to assess the perturbation of any quadratic response quantity of interest due to changes in resonance frequency. The analysis reveals that the bandwidth of response perturbation increases directly with increasing resonance frequency. This ‘‘proportional bandwidth’’ has bearing upon the so-called midfrequency gap in structural acoustics.
A study of metastatic mode and intraoperative diagnosis on nodal involvement in patients with early gastric cancer. (1987)

早期胃癌370例を対象とし, リンパ節転移様式と転移リンパ節の大きを検索し, リンパ節転移の術中肉眼診断について検討した.転移リンパ節98個の転移様式と個数, 平均長径, 術中肉眼正診率は, 辺縁洞型30個, 6.1mm, 20%, 部分的髄内洞型37個, 7.5mm, 21.6%, 広範囲髄内洞型11個, 6.6mm, 27.3%, 小結節型3個, 7.7mm, 33.3%, 大結節型17個, 8.4mm, 17.6%であり, 転移のないリンパ節1,086個の平均長径は4.5mm, 術中肉眼正診率は97.6%であった.転移リンパ節の長径別術中肉眼正診率は5mm未満13.9%, 5～10mm17.5%, 10～15mm20.0%, 15mm以上58.3%と15mm未満の正診率が低かった.以上より術中肉眼診断を基にしたリンパ節の温存は転移を残す危険性が大きいことが示唆された.
Endoscopic ultrasound of the stomach (1993)

Abstract Endoscopic ultrasound (EUS) is the adopted term for the technique which enables endoluminal ultrasound to be performed using a specially designed endoscope with a fixed piezoelectric transducer. Since initial reports described the use of this technique in patients, its use in clinical practice in Europe, the Far East and the USA has been steadily increasing over the past few years. At present the technique is only practised in a very few centres in the UK but it is likely that this will increase in the future. This article describes the present day value of EUS in evaluating gastric pathology.
Convergence of photonics and electronics for Terahertz wireless communications - the ITN CELTA project (2016)

Terahertz wireless communications is expected to offer the required high capacity and low latency performance required from short-range wireless access and control applications. We present an overview of some the activities in this area in the newly started H2020 ITN project CELTA: convergence of electronics and photonics technologies enabling Terahertz applications
Proportional Systems in the History of Architecture: A Conversation with James S. Ackerman (2014)

In November 2010, James S. Ackerman, today the only living participant of the conference ‘De divina proportione’, which was held in Milan in 1951, sat for a video interview that was later shown at the conference ‘Proportional Systems in the History of Architecture’ in Leiden in 2011 to mark the sixtieth anniversary of the Milan conference. In this interview, conducted by Matthew A. Cohen, Ackerman discusses how the study of proportional systems has changed over the past six decades, and thereby provides a unique link between the two conferences. The interview begins with Ackerman’s experiences in northern Italy at the close of World War II, and a few years later at the Milan conference. It considers prevailing twentieth-century attitudes toward proportion up to the time of the conference, and compares them with prevailing medieval and Renaissance attitudes. Ackerman then shares his thoughts on the works and legacies of Rudolf Wittkower, Le Corbusier and Colin Rowe, before exploring the influences of architectural proportional theory on architectural design, and possible relationships between proportional systems and architectural beauty. After exploring changes in the uses of proportional systems that accompanied the rise of Abstract Expressionism, the arc of the interview concludes with Ackerman’s thoughts about the future of proportional systems in light of the evolving role of the computer in architectural practice today.
Förster resonance energy transfer by formation of a mechanically interlocked [2]rotaxane (2013)

A [2]rotaxane has been constructed from a di-pyrene appended pillar[5]arene wheel, a pyridinium axle, and a perylene stopper. It shows efficient Förster resonance energy transfer from pyrene to perylene by formation of a mechanically interlocked [2]rotaxane.
Combating PCR Bias in Bisulfite-Based Cytosine Methylation Analysis. Betaine-Modified Cytosine Deamination PCR (1998)

Sodium bisulfite-induced cytosine deamination/PCR (CDPCR) is currently the most sensitive and robust method to determine the methylation status of all cytosines in a specific DNA sequence. The CDPCR products are directly sequenced with Thermosequenase and capillary electrophoresis; peak areas are then used to determine the mole fraction of methylated cytosines at each site in a single analysis. Here we show that, if the original DNA sample is a mixture of methylated and unmethylated DNA, conventional CDPCR discriminates against the sequence originating from the methylated DNA; CDPCR product does not accurately represent the methylation status of the original DNA sample. While CDPCR bias can lead to serious errors when determining methylation levels, the addition of betaine (N,N,N-trimethylglycine) to the PCR reaction buffer reduces this bias to less than 10%.
Olanzapine With or Without Fosaprepitant for Preventing Chemotherapy Induced Nausea and Vomiting in Patients Receiving Highly Emetogenic Chemotherapy: A Phase III Randomized, Double-Blind, Placebo-Controlled Trial (ALLIANCE A221602) (2023)

This trial did not provide sufficient evidence to support that deletion of the NK-1 receptor antagonist was as good as keeping it, as a part of a 4-drug antiemetic regimen for highly emetogenic chemotherapy (ClinicalTrials.gov Identifier: NCT03578081).
Reactions of iminodimagnesium reagents with 1,4‐quinones: Their structural factors governing the modes of reactions (1994)

Abstract Reactions of benzo‐, naphtho‐ and anthraquinone derivatives (unsubstituted and substituted) with aryliminodimagnesium [ArN(MgBr) 2 ] and aryloxymagnesium of a weak electron‐donating ability were studied. In addition to the reduction products (quinhydrones and hydroquinones), nuclear substitution and condensation magnified image products were formed. The efficiency of single electron transfer (SET) from ArN(MgBr) 2 , evaluated by the relative values of the difference between the oxidation and reduction potentials of the reactants (Δ E = E ox – E red ), varies with the electron‐accepting power of quinones. Δ E governs the modes of semiquinone appearance (ESR signals) and the relative amounts of the heat of reactions, reflecting the types and yields of the products. It is concluded that condensation products of both components are produced in the reactions of quinones with the lower SET efficiency by the presence of a fused benzene ring or MeO substituent. The structure–reactivity relationship proposed previously for reactions of various magnesium reagents is extended in the reactions with a variety of quinones even in cases of higher SET efficiency.
Reflectance Spectroscopy and Lunar Sample Science: Finally a Marriage After Far Too Long an Engagement (1998)

Inferences about the igneous and impact evolution of planetary bodies are based upon spectral remote sensing of their surfaces. However, it is not the rocks of a body that are seen by the remote sensing, but rather the regolith, that may contain small pieces of rock but also many other phases as well. Indeed, recent flybys of objects even as small as asteroid Ida have shown that these objects are covered by a regolith. Thus, spectral properties cannot be directly converted into information about the igneous history of the object. It is imperative to fully understand the nature of the regolith, particularly its finer fraction termed soil, to appreciate the possible effects of space weathering on the reflectance spectra. We have initiated a study of our nearest, regolith-bearing body, the Moon, as ground truth for further probes of planetary and asteroidal surfaces. the foundation for remote chemical and mineralogical analyses lies in the physics underlying optical absorption and the linking of spectral properties of materials measured in the laboratory to well understood mineral species and their mixtures. From this statement, it is obvious that there should be a thorough integration of the material science of lunar rocks and soils with the remote-sensing observations. That is, the lunar samples returned by the Apollo missions provide a direct means for evaluation of spectral characteristics of the Moon. However, this marriage of the remote-sensing and lunar sample communities has suffered from a prolonged unconsummated betrothal, nurtured by an obvious complacency by both parties. To make more direct and quantitative links between soil chemistry/mineralogy and spectral properties, we have initiated a program to (1) obtain accurate characterization of the petrography of lunar soils (in terms relevant to remote analyses), coupled with (2) measurement of precise reflectance spectra, with testing and use of appropriate analytical tools that identify and characterize individual mineral and glass components. It is the finest-sized fractions of the bulk lunar soil that dominate the observed spectral signatures.
Modeling splice sites with Bayes networks (2000)

kasif@eecs.uic.edu
Passive cyclic pitch control for horizontal axis wind turbines (1981)

A flexible rotor concept, called the balanced pitch rotor, is described. The system provides passive adjustment of cyclic pitch in response to unbalanced pitching moments across the rotor disk. Various applications are described and performance predictions are made for wind shear and cross wind operating conditions. Comparisons with the teetered hub are made and significant cost savings are predicted.
Experimental investigation of parametric and externally forced motion in resonant MEMS sensors (2008)

In this paper an excitation method employing both harmonic forcing and parametric excitation is applied to a resonant MEMS sensor in order to investigate and characterize the phenomena of parametric resonance and parametric amplification. The motivation for this research is that parametric excitation may be used to significantly reduce the total damping in MEMS sensors in a controllable manner. This is extremely pertinent to devices where the Q-factor is a principal factor in determining sensor performance. In this paper it is shown that, by adjusting the parametric excitation parameters (frequency, amplitude and phase) of an electrostatically actuated and sensed device, the gain of the frequency response function of a mode of vibration may be amplified. The amplification is quantified by the gain factor which is characterized experimentally. The instability regions defining the regions for parametric resonance are also characterized experimentally and compared to theoretical predictions. The boundaries of these instability regions define the thresholds for parametric resonance and play a crucial role in the design of the parametric amplifier.
Brachial Artery Dimensions, Reactivity And Distensibility With Advancing Age (2005)

PURPOSE To examine brachial artery diameter, reactivity, distensibility, and pulse pressure from the second through the tenth decade of life. METHODS A total of 86 men (Age: 56±24, Range: 81, Min: 18, Max: 99 years) underwent highresolution ultrasonography (Toshiba Power vision SSA-380A, 7.5-MHz linear array transducer) of the brachial artery before and after 5 minutes of forearm occlusion. Prior to imaging subjects were instructed to fast and refrain from exercise for 12hr and alcohol for 48hr. Following 10min of supine rest, baseline images were obtained in longitudinal view. In addition, blood pressure and heart rates were obtained through out the procedure. Subsequently, subjects were categorized according to decade of life. Diastolic and systolic images were analyzed using semi-automated edge-detecting analysis software (Medical Imaging Applications, LLC). Brachial artery flow-mediated dilation (BAFMD) was defined as the percent change (%) in vessel diameter from rest to peak dilation following 5 min of forearm occlusion. Brachial arterial distensibility was characterized as a change in vessel cross-sectional area between diastole and systole over a change in pulse pressure (Kool M et al. 1994). Pulse pressure (PP) was calculated as systolic minus diastolic blood pressure RESULTS:For each decade of life resting brachial artery diameter (RBA) and PP increased. In contrast, BAFMD and distensibility decreased. These changes were best described by the following linear regressions: RBA=2.29+0.18* decade of life, r2=0.26 (Increase of 0.16 mm/decade); PP=19.71+4.79*decade of life, r2=0.35 (Increase of 4.26 mmHg/decade); BAFMD=11.77- 0.91* decade of life, r2=0.26 (Decrease of 0.80 %/decade); Distensibility =0.0015+ 0.00008* decade of life, r2=0.07, p=0.001 (Decrease of 0.7*10 -4μ/kPa/decade). Finally, BAFMD was significantly related to the RBA (r=−0.703, p=0.01), distensibility (r=0.426, p=0.01), and PP (r=−0.454, p=0.01. The influence of PP on BAFMD across the decades is described by the following equation: BAFMD=10.44–0.09*PP, r2=0.16. CONCLUSIONS These data confirm that advancing age is associated with increased resting diameter, reduced reactivity and distensibility of the brachial artery. A widening of PP may be a contributing factor or consequence of these vascular changes. Supported by the National Institute on Aging [P01 (AG022064091A1)] and the Louisiana Board of Regents through the Millennium Trust Health Excellence Fund [HEF (2001–06)02]
Neuroadapted Yellow Fever Virus Strain 17D: a Charged Locus in Domain III of the E Protein Governs Heparin Binding Activity and Neuroinvasiveness in the SCID Mouse Model (2008)

A molecular clone of yellow fever virus (YFV) strain 17D was used to identify critical determinants of mouse neuroinvasiveness previously localized to domain III of the neuroadapted SPYF-MN virus envelope protein. Three candidate virulence substitutions (305F-->V, 326K-->E, and 380R-->T) were individually evaluated for their roles in this phenotype in a SCID mouse model. The virus containing a glutamic acid residue at position 326 of the envelope protein (326E) caused rapidly lethal encephalitis, with a mortality rate and average survival time resembling those of the parental SPYF-MN virus. Determinants at positions 380 (380T) and 305 (305V) did not independently affect neuroinvasiveness. Testing a panel of viruses with various amino acid substitutions at position 326 revealed that attenuation of neuroinvasiveness required a positively charged residue (lysine or arginine) at this position. Molecular-modeling studies suggest that residues 326 and 380 contribute to charge clusters on the lateral surface of domain III that constitute putative heparin binding sites, as confirmed by studies of heparin inhibition of plaque formation. The neuroinvasiveness of YFVs in the SCID model correlated inversely with sensitivity to heparin. These findings establish that residue 326 in domain III of the E protein is a critical determinant of YFV neuroinvasiveness in the SCID mouse model. Together with modeling of domain III from virulent YFV strains, the data suggest that heparin binding activity involving lysine at position 326 may be a modulator of YFV virulence phenotypes.
Laser microprocessing of stent for medical therapy (2002)

In the medical application of stent therapy, especially in coronary heart disease, a metallic stent of high quality demands the ability for precision micromaterial processing. It possesses an inherent advantage of adequate radio-opacity. This paper describes the fabrication of such a metallic stent of length 20 mm and dia. 2.1 mm with an annular tube thickness of 0.2 mm, by using a pulsed Nd:YAG laser. Fine structures with a slit width of 0.1 mm and a pitch better than 0.4 mm are created with sharpness and low roughness in the cut surface. Some features of the reduced heat affected zone and dross removal process of the cut surface are also discussed.
The use of microsatellite genotyping for population studies in the pig with individual and pooled DNA samples (2003)

International audience
Use of Liner Drilling Technology as a Solution to Hole Instability and Loss Intervals: A Case Study Offshore Indonesia (2010)

Summary The Banuwati field offshore southeast Sumatra, Indonesia, presents major challenges to both drilling and liner running operations because of the problematic lower Baturaja limestone formation, which is a carbonate reef structure known for severe lost-circulation conditions. The operator previously had experienced severe losses with wellbore-stability issues while drilling this formation with the inability to set the 7-in. drilling liner at the planned depth in Well A-3. The liner had to be pulled out of the hole, leading to the eventual abandonment of the existing openhole section and resulting in the sidetracking of the well. Liner-while-drilling technology was identified as the most suitable solution for setting the planned 7-in. drilling liner through the loss interval because of the following: Documented lost-circulation problems have been minimized or eliminated through the use of liner drilling technology possibly attributed to the "smear effect" (Fontenot et al. 2004) phenomenon.The liner system selected provided for high torsional capability as well as the requirement for both a mechanical and a pressure event to release the setting tool, thus minimizing the chances of premature release.A drill shoe with a displaceable polycrystalline-diamond-compact (PDC) cutting structure was used to drill the 8½-in. hole section and subsequently displaced before cementing so as to allow drill out with a conventional drill bit and bottomhole assembly (BHA). This paper will discuss the implementation of liner drilling technology in the Banuwati field project. This technology was used to drill successfully through the known lost-circulation zone with the 7-in. liner cemented in place, allowing the operator to reach the completion objectives while realizing a savings of more than USD 1 million.
Global Named Patient Use Program of Afatinib in Advanced Non-Small-Cell Lung Carcinoma Patients Who Progressed Following Prior Therapies (2018)

Time to treatment failure durations and objective response rates were encouraging.
Studies on an Inhibitor of Erythropoiesis. II. Inhibitory Effects of Serum from Uremic Rabbits on Heme Synthesis in Rabbit Bone Marrow Cultures (1975)

The effects of sera from anephric rabbits on the rate of heme synthesis in erythroid cells were studied in vitro in rabbit bone marrow cultures. Sera from nephrectomized rabbits significantly (p smaller than 0.05) inhibited 59-Fe incorporation into heme in normal rabbit bone marrow cultures incubated with erythropoietin (ESF) when compared with the response in control culutres with normal serum and ESF. This inhibitory activity increased exponentially with increasing concentrations of the serum in cultures suggesting that a higher concentration of the inhibitor is present in uremia and may be the result of the failure to excrete the inhibitor. This suggests that the retention of this inhibitor may play an important role in the mechanism of the anemia of uremia. The inhibitor of heme synthesis is a low molecular weight substance.
Cancers beget mutations versus mutations beget cancers. (1994)

Despite the plethora of "oncogenes" and "tumor suppressor genes," the hypothesis that cancer is usually the result of genomic mutations may be wrong. We should at least examine the alternative hypothesis, for which there is considerable evidence, that mutations do not commonly beget cancer, but rather that cancer phenotypes result from confused or aberrant patterns of normal-gene expression; the abnormal patterns are postulated to result from epigenetic mechanisms rather than from mutations. The epigenetic hypothesis that I am proposing suggests that cancers may exhibit mutations primarily because replicative errors at inactive sites in the cancer genome may be repaired slowly or not at all, but the mutations so produced, occurring at already inactivated sites in the genome, may have limited biological significance. Thus, it may be more correct to say that cancers beget mutations than it is to say that mutations beget cancers.
Nonpeptide αvβ3 Antagonists. Part 9. Improved Pharmacokinetic Profile Through the Use of an Aliphatic, Des‐amide Backbone. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
DEKKER'S “BACK-DOOR'D ITALIAN”: “1 HONEST WHORE”, II. i. 355 (1960)

DEKKER'S “BACK-DOOR'D ITALIAN”: “1 HONEST WHORE”, II. i. 355 Get access ROBERT K. TURNER, JR. ROBERT K. TURNER, JR. Virginia Military Institute Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 7, Issue 1, 1 January 1960, Pages 25–26, https://doi.org/10.1093/nq/7-1-25 Published: 01 January 1960