PD25-02 DIAGNOSTIC ACCURACY OF PROBE BASED CONFOCAL LASER ENDOMICROSCOPY IN BLADDER CANCER (2015)

You have accessJournal of UrologyBladder Cancer: Detection and Screening II1 Apr 2015PD25-02 DIAGNOSTIC ACCURACY OF PROBE BASED CONFOCAL LASER ENDOMICROSCOPY IN BLADDER CANCER Seong Uk Jeh, Hae Do Jung, Jong Kyou Kwon, Ho Won Kang, Joo Yong Lee, Kang Su Cho, Won Sik Ham, Yong Jin Kang, and Young Deuk Choi Seong Uk JehSeong Uk Jeh More articles by this author , Hae Do JungHae Do Jung More articles by this author , Jong Kyou KwonJong Kyou Kwon More articles by this author , Ho Won KangHo Won Kang More articles by this author , Joo Yong LeeJoo Yong Lee More articles by this author , Kang Su ChoKang Su Cho More articles by this author , Won Sik HamWon Sik Ham More articles by this author , Yong Jin KangYong Jin Kang More articles by this author , and Young Deuk ChoiYoung Deuk Choi More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1651AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Probe based confocal laser endomicroscopy (pCLE) is a novel optical technology designed for real-time, in vivo histological assessment without taking biopsy. We evaluate the diagnostic accuracy of pCLE in prospective examination of bladder neoplastic lesions. METHODS Patients were prospectively recruited to undergo transurethral resection of bladder (TURBT) based on abnormal cystoscopy. After white-light cystoscopy (WLC), CLE was performed to obtain diagnostic images. Confocal images were compared to histologic result using sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). RESULTS In total 51 patients with 104 lesions were evaluated comprising 19 benign lesions (2 papilloma, 16 inflammation, 1 low malignant potential) and 85 malignant lesions (12 low grade, 55 high grade, 18 carcinoma in situ). The pCLE was found to have a cancer detection rate of 96.47%, and a false positive rate of 8.9%. The overall sensitivity for diagnosis of high grade papillary tumor versus low grade papillary tumor was 89.09% (95% confidence interval [CI], 80.85-97.33), specificity was 75.00% (95% CI, 50.5-99.5), PPV was 94.23% (95% CI, 87.89-100.57), and the NPV was 60.00% (95% CI, 35.21-84.79). The overall sensitivity for diagnosis of CIS versus inflammation was 83.33% (95% CI, 66.12-100.55), specificity was 62.50% (95% CI, 38.78-86.22), PPV was 71.43% (95% CI, 52.11-90.75), and the NPV was 76.92% (95% CI, 54.02-99.83). CONCLUSIONS The pCLE is promissing method for detection of malignant lesion, high grade papillary tumor and carcinoma in situ (CIS). Therefore, use of pCLE may minimize the recurrence and positive resection margins associated with conventional white-light cystoscopic biopsy, ensure complete TURBT. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e560 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Seong Uk Jeh More articles by this author Hae Do Jung More articles by this author Jong Kyou Kwon More articles by this author Ho Won Kang More articles by this author Joo Yong Lee More articles by this author Kang Su Cho More articles by this author Won Sik Ham More articles by this author Yong Jin Kang More articles by this author Young Deuk Choi More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...