gebhart/patrepeval huggingface dataset:
Platelet Depletion Causes Rapid But Transient Activation Of Mouse Bone Marrow Long-Term Hematopoietic Stem Cells To Participate In Stress Thrombopoiesis (2013)

Abstract Hematopoietic stem cells (HSCs) are responsible for the production of various lineages of blood cells throughout life. To ensure the longevity of HSCs and prevent their premature exhaustion, a small population of HSCs termed long-term HSCs (LT-HSCs) is maintained in quiescence under homeostatic conditions. Whether LT-HSCs can exit quiescence rapidly in response to hematopoietic stress to replenish blood cells is not known, and thus was investigated in the present study in an acute but transient platelet depletion mouse model induced by intravenous injection of anti-GPIbα antibody. The results from our study show that in response to platelet depletion LT-HSCs can exit quiescence promptly and then proliferate rapidly to participate in stress thrombopoiesis probably via an alternative differentiation pathway. The mechanism by which platelet depletion causes LT-HSC activation is not due to a direct effect of the antibody on LT-HSCs or activation of platelets, but is attributed to a transient reduction of thrombopoietin (TPO) resulting from the acute depletion of platelets. However, the activated LT-HSCs return to quiescence when blood platelet counts are almost back to normal levels without compromising their function. These findings suggest that there is a very efficient and sensitive feedback regulatory circuitry between quiescent LT-HSCs and platelets, which allows LT-HSCs to directly and promptly respond to hematopoietic stress resulting from an acute loss of platelets. In this response, TPO may function as a switch that can rapidly turn on LT-HSCs to participate in stress thrombopoiesis. Disclosures: No relevant conflicts of interest to declare.
Performance of a patch antenna fabricated from carbon fibers/glass fibers composite material (2013)

International audience
Peroneal intraneural ganglia (2007)

The common peroneal nerve is the peripheral nerve most often affected by intraneural ganglion cysts. Although the pathogenesis of these cysts has been the subject of controversy in the literature, it is becoming increasingly evident that they are of articular origin. Recent recognition of this fact has proven to be significant in reducing recurrences and improving treatment outcomes for patients. The authors present a stepwise method of assessing and treating peroneal intraneural ganglion cysts.
Extending optics to 50 nm and beyond with immersion lithography (2003)

Numerical imaging simulations demonstrate the capability of immersion lithography to print features smaller than 45 nm (35 nm) with good depth of focus at a vacuum wavelength of 193 nm (157 nm). The optical impact of index variation of the immersion liquid is simulated and found to be a shift of focus of 1 nm for each 1 ppm change in the bulk index of the liquid. For an index which varies through the thickness of the liquid (e.g., due to nonuniform temperature), the focus shift is found to be proportional to the total change in optical path length (OPL), with a 1 nm change in OPL leading to a ∼1.5 nm focus shift at 1.3 numerical aperture. A focus offset of 1–3 nm can be expected due to heating during scanning exposure. The possible formation of nanobubbles at resist surfaces is also discussed. While simulations show that even 10 nm thick bubbles at the surface of the resist cause 30% modulation in the aerial image intensity, no evidence of bubbles is seen in open frame immersion exposures. Imaging of 100 nm features is shown using an immersion contact phase-edge technique, with no evidence of bubbles or adverse liquid–resist interactions. Finally, we describe progress in the search for low absorbance liquids for use at 157 nm. Liquid purity, including dissolved O2 and H2O, is found to be critical. The current absorbance record, 0.64±0.07 cm−1, held by perfluorotriglyme (CF3[OCF2CF2]3OCF3), is enough for a 350 μm working distance at 95% transmission.
Coordinated Metabolism of Alcadein and Amyloid β-Protein Precursor Regulates FE65-dependent Gene Transactivation (2004)

The Alcadeins (Alcs)/calsyntenins and the amyloid beta-protein precursor (APP) associate with each other in the brain by binding via their cytoplasmic domains to X11L (the X11-like protein). We previously reported that the formation of this APP-X11L-Alc tripartite complex suppresses the metabolic cleavages of APP. We show here that the metabolism of the Alcs markedly resembles that of APP. The Alcs are subjected to a primary cleavage event that releases their extracellular domain. Alcs then undergo a secondary presenilin-dependent gamma-cleavage that leads to the secretion of the amyloid beta-protein-like peptide and the liberation of an intracellular domain fragment (AlcICD). However, when Alc is in the tripartite complex, it escapes from these cleavages, as does APP. We also found that AlcICD suppressed the FE65-dependent gene transactivation activity of the APP intracellular domain fragment, probably because AlcICD competes with the APP intracellular domain fragment for binding to FE65. We propose that the Alcs and APP are coordinately metabolized in neurons and that their cleaved cytoplasmic fragments are reciprocally involved in the regulation of FE65-dependent gene transactivation. Any imbalance in the metabolism of Alcs and APP may influence the FE65-dependent gene transactivation, which together with increased secretion of amyloid beta-protein may contribute to neural disorders.
Genitourinary syndrome of menopause. Prevalence and quality of life in Spanish postmenopausal women. The GENISSE study (2018)

The GSM is very prevalent in Spanish postmenopausal women, affecting up to 70% of those consulting the gynecologist. Despite the high prevalence of symptoms and signs and its impact on the women's well-being, GSM remains underdiagnosed and undertreated. Given its relationship with urogynecological conditions, it seems necessary to provide an adequate evaluation of postmenopausal women for identifying potential co-morbidities and providing most adequate treatments. An adequate management of GSM will contribute to an improvement in the quality of life of these women.
Effects of Sustained-Release Diltiazem on Blood Pressure and Serum Lipids (1990)

A randomized, double-blind dose-response study on the antihypertensive action of sustained-release diltiazem was performed in four parallel groups. The aim of the trial was to evaluate the antihypertensive efficacy of sustained-release diltiazem and its dose-dependent clinical and biological tolerance. The four homogeneous groups consisted of 25 patients each who had presented with mild to moderate hypertension (diastolic blood pressure of 95-115 mm Hg) in the supine position. The study protocol comprised three successive periods: a placebo period lasting 14 days to verify the persistence of arterial hypertension under placebo; a first therapeutic period during which each of the 25 patients of the four groups received a single daily dose every morning at 9 a.m. of a capsule containing 0.240, 300, or 360 mg of sustained-release diltiazem over a period of 28 days; and a second therapeutic period during which the patients of the four groups received 240, 300, 360, and 300 mg, respectively. All other antihypertensive treatment had been suspended at least 15 days before the initial period under placebo. The results were evaluated with respect to clinical parameters such as systolic blood pressure, diastolic blood pressure, and heart rate, which were measured at 9 a.m. 24 h after the last administration of the drug on days 14, 28, and 56. The plasma serum levels of diltiazem were measured on days 28 and 56, the biological parameters, including measurements of hepatic and renal function as well as lipid and glucose levels, on days 14 and 56, and electrocardiography was performed on days 14, 28, and 56.(ABSTRACT TRUNCATED AT 250 WORDS)
Ovine Prolactin (PRL) and Dopamine Preferentially Inhibit PRL Release from the Same Subpopulation of Rat Mammotropes* (1986)

Autoregulation of PRL release was studied at the single cell level by the use of a reverse hemolytic plaque assay. Monodispersed pituitary cells from adult male rats were first preincubated with test substances and then coincubated with antirat PRL antiserum before development of plaques with complement. At the conclusion of the assay, the percentage of all pituitary cells in culture that formed plaques was evaluated microscopically, and the rate of plaque development was used as an index for the rate of hormone release. In controls, the maximal percentage of pituitary cells formed PRL plaques within a 1.5-h antibody incubation period, and addition of TRH (1 X 10(-7) M) did not increase this proportion. Treatment with ovine PRL (oPRL, 100 ng/ml) or dopamine (1 X 10(-7) M), either alone or in combination, caused a comparable suppression of the rate of PRL plaque development, which was reversed by the presence of TRH. Pretreatment of cells with the lysosomotropic agent chloroquine (1 X 10(-5) M) overrode dopamine inhibition of PRL plaque development, but did not influence oPRL inhibition. Taken together, these results demonstrate that oPRL inhibits basal, but not TRH-induced, PRL release from rat pituitary cells and support the view that PRL can act at the pituitary level to inhibit its own secretion. Moreover, the equipotency and lack of additivity exhibited by oPRL and dopamine coupled with the differential effects of chloroquine suggest that these factors both act upon the same subpopulation of mammotropes to inhibit PRL release, but by separate intracellular mechanisms.
Parent Ion Scans of Unseparated Peptide Mixtures (1996)

The nanoelectrospray ion source (NanoES) developed recently has proven to be an excellent tool for the sequencing of peptides out of unseparated mixtures. At lower levels of analyte, however, it is increasingly difficult to distinguish the peptide ions in the spectrum, limiting the overall sensitivity of the procedure. Scans for the parents of common fragmentation products of peptides such as immonium ions allow determination of peptide ion masses even when these ions have signal-to-noise ratios of < 1 in the mass spectrum. With this technique, concentration limits for sequencing peptides could be improved to < 5 fmol/microL in favorable cases. Parent ions scan were used to identify posttranslational modifications of peptides in mixtures, with phosphorylation and glycosylation as examples. Detecting phosphorylation by parent scans increased sensitivity by 1-2 orders of magnitude. Modified peptides can be subjected to tandem mass spectrometry in the same experiment to localize the modification. The present approach expands the range of application of nanoelectrospray and complements established liquid chromatography/mass spectrometry methods.
Modeling nitrogen plasmas produced by intense electron beams (2016)

A new gas–chemistry model is presented to treat the breakdown of a nitrogen gas with pressures on the order of 1 Torr from intense electron beams with current densities on the order of 10 kA/cm2 and pulse durations on the order of 100 ns. For these parameter regimes, the gas transitions from a weakly ionized molecular state to a strongly ionized atomic state on the time scale of the beam pulse. The model is coupled to a 0D–circuit model using the rigid–beam approximation that can be driven by specifying the time and spatial profiles of the beam pulse. Simulation results are in good agreement with experimental measurements of the line–integrated electron density from experiments done using the Gamble II generator at the Naval Research Laboratory. It is found that the species are mostly in the ground and metastable states during the atomic phase, but that ionization proceeds predominantly through thermal ionization of optically allowed states with excitation energies close to the ionization limit.
The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, MN. III. Correlations and covariances. (1994)

The gender-specific influence that the apolipoprotein E (ApoE) polymorphism has on the correlations and covariances between pairs of nine plasma lipid and apolipoprotein traits (total cholesterol; in triglycerides; high-density-lipoprotein cholesterol; apolipoproteins AI, AII, B, CII, lnCIII, and lnE) was studied in 507 unrelated individuals representative of the adult population of Rochester, MN. Analyses are presented separately for females and males. The Apo E polymorphism had a significant influence on a large number (10 of 36) of correlations and covariances in females and on a small number (3 of 36) in males. The contribution of allelic variation in the Apo E gene to the definition of multivariate measures of the 36-dimensional correlation structure was evaluated. The influence of Apo E genotype on correlation structure was gender dependent. These findings were used to demonstrate how heterogeneity of risk-factor correlations and covariances among genotype-gender subgroups of the population at large may influence the evaluation of risk of coronary artery disease.
Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells (2016)

Glucose is an important inducer of insulin secretion, but it also stimulates long-term adaptive changes in gene expression that can either promote or antagonize the proliferative potential and function of β cells. Here, we have generated time-resolved profiles of enhancer and transcriptional activity in response to glucose in the INS-1E pancreatic β cell line. Our data outline a biphasic response with a first transcriptional wave during which metabolic genes are activated, and a second wave where cell-cycle genes are activated and β cell identity genes are repressed. The glucose-sensing transcription factor ChREBP directly activates first wave enhancers, whereas repression and activation of second wave enhancers are indirect. By integrating motif enrichment within late-regulated enhancers with expression profiles of the associated transcription factors, we have identified multiple putative regulators of the second wave. These include RORγ, the activity of which is important for glucose-induced proliferation of both INS-1E and primary rat β cells.
Person Search in Videos with One Portrait Through Visual and Temporal Links (2018)

In real-world applications, e.g. law enforcement and video retrieval, one often needs to search a certain person in long videos with just one portrait. This is much more challenging than the conventional settings for person re-identification, as the search may need to be carried out in the environments different from where the portrait was taken. In this paper, we aim to tackle this challenge and propose a novel framework, which takes into account the identity invariance along a tracklet, thus allowing person identities to be propagated via both the visual and the temporal links. We also develop a novel scheme called Progressive Propagation via Competitive Consensus, which significantly improves the reliability of the propagation process. To promote the study of person search, we construct a large-scale benchmark, which contains 127K manually annotated tracklets from 192 movies. Experiments show that our approach remarkably outperforms mainstream person re-id methods, raising the mAP from 42.16% to 62.27%.
Abstract 5684: Protein homeostasis modulation is critical for cancer cell survival upon chaperone mediated proteotoxic stress (2022)

Abstract Cancer cells survive under extreme environments that alter protein homeostasis, thereby provoking cellular stress responses, such as the unfolded protein response (UPR) and the integrated stress response (ISR). These pathways increase the expression of molecular chaperones to prevent the accumulation of toxic proteins in the cell. One molecular chaperone in particular, Hsp70, plays a central role in both cellular protection and the response to proteotoxic insults. This is perhaps most evident in cancer cells, some of which overexpress Hsp70 and thrive even when harboring high levels of misfolded, aggregated, and/or unassembled protein complexes. In an effort to define how cells compensate for compromised proteostasis, we examined the adaptive response in breast cancer cells after challenge with a specific Hsp70 inhibitor. We first showed that established breast cancer cell lines bin into classes based on their sensitivity to the drug. We next discovered that resistant cells have higher autophagy levels compared to the more sensitive lines. Moreover, gene and protein expression studies and imaging methods showed that autophagy was further induced by Hsp70 inhibition in resistant breast cancer cells. Consistent with the fact that Hsp70 normally targets aberrant proteins for degradation, our data indicated that resistance to compromised Hsp70 activity arose from elevated levels of autophagy. We next showed that Hsp70 inhibition specifically triggers the ISR pathway. Unexpectedly, protection against the Hsp70 inhibitor was dependent on the ISR sensor, GCN2, which is most commonly associated with the amino acid starvation response. In contrast, sensitive cells succumbed to Hsp70 inhibition by activating the PERK pathway. These data reveal an unexpected route through which cancer cells can adapt to chaperone targeted-proteotoxicity and position GCN2 and autophagy as critical compensatory mechanisms for cancer cells when proteostasis is compromised. Citation Format: Sara Sannino, Jeffrey L. Brodsky. Protein homeostasis modulation is critical for cancer cell survival upon chaperone mediated proteotoxic stress [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5684.
Tracing patterns and attention: humanoid robot cognition (2000)

Humanoid robots promise to lead us toward more effective and informative interactions between humans and robotic devices. The authors introduce mechanisms for attention control and pattern categorization as the basis for cognition in a humanoid robot.
Centre-manifold reduction of bifurcating flows (2015)

Abstract In this paper we describe a general and systematic approach to the centre-manifold reduction and normal form computation of flows undergoing complicated bifurcations. The proposed algorithm is based on the theoretical work of Coullet &amp; Spiegel ( SIAM J. Appl. Maths , vol. 43(4), 1983, pp. 776–821) and can be used to approximate centre manifolds of arbitrary dimension for large-scale dynamical systems depending on a scalar parameter. Compared with the classical multiple-scale technique frequently employed in hydrodynamic stability, the proposed method can be coded in a rather general way without any need to resort to the introduction and tuning of additional time scales. The method is applied to the dynamical system described by the incompressible Navier–Stokes equations showing that high-order, weakly nonlinear models of bifurcating flows can be derived automatically, even for multiple codimension bifurcations. We first validate the method on the primary Hopf bifurcation of the flow past a circular cylinder and after we illustrate its application to a codimension-two bifurcation arising in the flow past two side-by-side circular cylinders.
Forced Air Cooling of a High-Speed Permanent Magnet Motor (2018)

This paper discusses the cooling of a 100 kW high-speed permanent-magnet (PM) motor, with a maximum circumferential velocity of 117 m/s. The electrical losses have been calculated by a two-dimensional time-stepping finite element model and the cooling has been analyzed with computational fluid dynamics. Calorimetric measurements have been performed on a prototype. Computational and experimental results are compared for three different operation points. The results of the study indicate a need for improved steady-state models of high-speed PM motors. Available simulation tools overestimate rotor heating and underestimate stator heating. It is urged for further experimental and simulation analyzes.
Impact of angiotensin receptor blockers on mortality after hospitalization for symptomatic lower extremity artery disease (2020)

Angiotensin receptor blockers at discharge after hospitalization for symptomatic LEAD is associated with a better survival compared with ACEI or no ACEI/ARB.
SERUM IMMUNOREACTIVE INTERLEUKIN 1 IN RENAL TRANSPLANT RECIPIENTS (1988)

A solid-phase radioimmunoassay was used for monitoring serum interleukin 1 levels in 12 renal transplant recipients. From 10-fold to 20-fold elevations of interleukin 1 occurred in association with 10 of 12 graft rejection episodes. The interleukin 1 elevation preceded the clinical rejection diagnosis by an average of one day in transplant recipients with initially functioning grafts, and by two days in recipients with delayed onset of graft function. The results show that the release of interleukin 1 into the circulation is an early event in renal allograft rejection and demonstrate the potential utility of interleukin 1 antigenic assays in the early diagnosis of rejection.
TGF-.BETA. Completely Blocks the Formation of Small-Cell Colonies: Effects of Mito-inhibitory Factors on the Proliferation of Primary Cultured Rat Hepatocytes. (1995)

The proliferation of primary cultured rat hepatocytes was observed in serum-free modified DMEM supplemented with 10 mM nicotinamide and 10 ng/ml EGF. These proliferating cells were mainly mononucleate and formed small-cell colonies after 4 days of culture. In the present experiment primary cultured hepatocytes were treated with Activin A, IL-1 beta, IL-6, and TGF-beta, which have been shown to be inhibitors of the DNA synthesis of rat hepatocytes, to examine whether these four inhibitors could suppress the formation of small-cell colonies. The initial DNA synthesis of more than 50% of the cells was dose-dependently inhibited by all the factors and the strongest inhibition was demonstrated in the cells treated with TGF-beta. Although Activin A and IL-6 did not block the colony development when the agents were administered at 96 h, just before the time when the cells started to form colonies, TGF-beta and IL-1 beta could inhibit the colony formation completely and partially, respectively. Transient treatment (48-72 h) with TGF-beta was enough to suppress colony development, while Activin A and IL-6 did not block the formation of colonies. IL-1 beta partially suppressed this formation. However, continuous administration (48-144 h) of IL-beta as well as TGF-beta stimulated the detachment of the cells from dishes and the remaining hepatocytes failed to form colonies. In addition, only TGF-beta could inhibit the DNA synthesis of most small cells in the established colonies as well as that of relatively large hepatocytes. Neither Activin A, IL-1 beta nor IL-6 could inhibit the DNA synthesis of the small cells. Thus, only TGF-beta could completely inhibit both the DNA synthesis of any type of hepatocyte and the formation of small-cell colonies.
Codebook Adaptation for Quantized MIMO Beamforming Systems (2006)

Quantized multiple-input multiple-output (MIMO) beamforming systems use predesigned codebooks for the quantization of transmit beamforming vectors. The quantized vector, which is conveyed to the transmitter using a low-rate feedback channel, is used for transmission to provide significant diversity and array gain. The codebook for quantization is a function of the channel distribution, and is typically designed for fixed channel distributions. In this paper, we propose a channel adaptive feedback strategy for arbitrary channel distributions, and present a simple codebook design methodology based on the channel statistics. The codebook for quantization is dynamically chosen rom a structured set of pre-designed codebooks, called the code set, wherein all codebooks are derived from one mother codebook. Simulations illustrate that the proposed method can improve error rate performance in correlated and/or channels with strongly line-of-sight components