gebhart/patrepeval huggingface dataset:
Cholinergic regulation of arterial pressure by the C1 area of the rostral ventrolateral medulla (1989)

In anesthetized, paralyzed rats intravenous administration of the acetylcholinesterase inhibitor physostigmine (PHY) (100 micrograms/kg) evoked a dose-related rise in arterial pressure (AP) and heart rate (HR) and an associated increase in sympathetic nerve activity (SNA). The responses to PHY were blocked by electrolytic lesions of, or microinjection of kainic acid into, a specific site in the rostral ventrolateral medulla containing a cluster of neurons immunoreactive for the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase and corresponding to the C1 area of the nucleus reticularis rostroventrolateralis (RVL). The C1 area and its surround contain a heretofore unrecognized network of varicose neuronal processes and perikarya labeled immunocytochemically with a monoclonal antibody to the ACh-synthesizing enzyme, choline acetyltransferase (CAT). PHY increased, by over 3-fold, the spontaneous activity of reticulospinal cardiovascular neurons in the C1 area which excite preganglionic sympathetic neurons in the intermediolateral spinal column. The effects of PHY on AP, SNA, and the discharge of reticulospinal neurons were blocked by systemic administration of the muscarinic antagonist scopolamine. Microinjections within the C1 area of the RVL of scopolamine, the M2-selective muscarinic receptor antagonist AF-DX 116, or the high-affinity choline uptake inhibitor hemicholinium-3 blocked the pressor effects of PHY. The nicotinic antagonist hexamethonium and the M1-selective muscarinic receptor antagonist pirenzepine were without effect. We conclude that (1) the increases in AP, HR, and SNA elicited by the systemic administration of PHY result from the augmented action of ACh released from cholinergic terminals within the C1 area of the RVL; (2) the locally released ACh acts through muscarinic receptors of the M2 subtype within the C1 area to produce excitation of intrinsic reticulospinal sympathoexcitatory neurons, thereby increasing the activity of sympathetic preganglionic neurons and consequently elevating AP and HR; and (3) while the specific function of the cholinergic innervation of the C1 area in cardiovascular regulation is unknown, it may contribute to the tonic regulation of AP.
Surface Acidity and Basicity of La2O3, LaOCl, and LaCl3 Characterized by IR Spectroscopy, TPD, and DFT Calculations. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Investigation of retinal damage during refractive eye surgery (2005)

Ultrashort laser pulses are increasingly used in refractive eye surgery to cut inside transparent corneal tissue. This is exploited by the fs-LASIK procedure which affords the opportunity to correct ametropia without any mechanical effects. The cutting process is caused by the optical breakdown occurring in the laser focus. During this process only a certain amount of the pulse energy is deposited into the tissue. The remaining pulse energy propagates further through the eye and interacts with the retina and the strong absorbing tissue layers behind. Therefore this investigation shall clarify if the intensity of the remaining laser pulse and the resulting temperature field can damage the retina and the surrounding tissue. Threshold values of the retinal tissue and theoretical calculations of the temperature field will be presented.
Preparation of the Superconducting Nb3Ge Tape by a Continuous CVD Process (1977)

Superconducting Nb3Ge tapes were produced by a continuous chemical vapour deposition. The critical current density of these tapes was the order of 105 A/cm2 at 100 kOe and 4.2 K. The upper critical field was estimated to be 320 kOe at 0 K. The maximum onset temperature of the superconducting transition was 20.5 K.
Pancreatic Metastasis from Renal Cell Carcinoma Extending into the Main Pancreatic Duct: a Case Report (2002)

While metastasis to the pancreas is uncommon, it may occur from renal cell carcinomas (RCCs). We here present a case of pancreatic metastasis from RCC extending into the main pancreatic duct (MPD) in a 66-year-old Japanese man. The patient had a history of RCC treated with a radical nephrectomy 17 years previously and was found to have a mass approximately 2 cm in diameter in the body of the pancreas on radiological images. The patient was suspected of having pancreatic metastasis from RCC and underwent a distal pancreatectomy with splenectomy. Histologically, the tumor consisted of cells arranged in trabecular and alveolar structures with clear or eosinophilic granular cytoplasm, compatible with a metastatic RCC. The pancreatic tumor extended into the MPD with the stream of pancreatic juice. This condition is similar to RCC extension into the renal vein and the inferior vena cava. In conclusion, although extension into the MPD may be rare, such a growth pattern may be characteristic of metastases from RCCs.
DNA Methylation Changes in Atypical Adenomatous Hyperplasia, Adenocarcinoma In Situ, and Lung Adenocarcinoma (2011)

The gradual increase in DNA methylation seen for numerous loci in progressively more transformed lesions supports the model in which AAH and AIS are sequential stages in the development of lung adenocarcinoma. The demarcation of DNA methylation changes characteristic for AAH, AIS and adenocarcinoma begins to lay out a possible roadmap for aberrant DNA methylation events in tumor development. In addition, it identifies which DNA methylation changes might be used as molecular markers for the detection of preinvasive lesions.
Subminiature transducers and their acoustic coupling: State of the art (1979)

Until recently, the transducers that were available to the hearing aid designer imposed major limitations on the performance which could be offered in headworn hearing aids. Within the last decade, however, these limitations have been largely removed. Today's subminiature microphones and earphones permit a wide variety of hearing aid characteristics, up to and including true high-fidelity performance: a claim substantiated in recent physical and psychophysical experiments [Killion, J. Acoust. Soc. Am. Suppl. 1 64, S103(A) (1978)]. The usable performance of subminiature transducers may be largely determined by their acoustic couplings—so much so that a meaningful definition of their frequency response requires that the coupling system be specified—and a crucial factor in recent performance improvements has been a systematic examination of the acoustic coupling systems available to headworn hearing aids. While sometimes considered a nuisance or worse, the acoustic couplings can be exploited in hearing aid design to (a) improve directional performance, (b) provide desirable frequency-response tailoring, and (c) reduce battery drain. Earmold construction in particular becomes increasingly important as the bandwidth of hearing aids is increased. At low (below 1 kHz), medium (1–3 kHz), and high (above 3 kHz) frequencies, the use of earmold venting, damping, and a stepped-diameter sound channel. respectively, can provide substantial (and predictable) modifications to the real-ear response of hearing aids; modifications which can often be performed at the dispenser level. Examples of the performance allowed by today's transducers and acoustic couplings will be given.
Phenotypic Features Associated with Mutations in Steroidogenic Acute Regulatory Protein (2005)

These cases broaden the spectrum of known StAR mutations and suggest that disorders of central nervous system development may arise because of StAR deficiency and/or the metabolic consequences of neonatal adrenal deficiency.
Collusion-secure and cost-effective detection of unlawful multimedia redistribution (2003)

Intellectual property protection of multimedia content is essential to the successful deployment of Internet content delivery platforms. There are two general approaches to multimedia copy protection: copy prevention and copy detection. Past experience shows that only copy detection based on mark embedding techniques looks promising. Multimedia fingerprinting means embedding a different buyer-identifying mark in each copy of the multimedia content being sold. Fingerprinting is subject to collusion attacks: a coalition of buyers collude and follow some strategy to mix their copies with the aim of obtaining a mixture from which none of their identifying marks can be retrieved; if their strategy is successful, the colluders can redistribute the mixture with impunity. A construction is presented in this paper to obtain fingerprinting codes for copyright protection which survive any collusion strategy involving up to three buyers (3-security). It is shown that the proposed scheme achieves 3-security with a codeword length dramatically shorter than the one required by the general Boneh-Shaw construction. Thus the proposed fingerprints require much less embedding capacity. Due to their own clandestine nature, collusions tend to involve a small number of buyers, so that there is plenty of use for codes providing cost-effective protection against collusions of size up to three.
Virus injection v1 (2020)

This protocol is used to inject viral vectors expressing proteins such as ion channels, transcription factors, enzymes, receptors, fluorescent proteins or other non-toxic, non-hazardous payloads. The viral vectors include AAV, Adenovirus, modified RV, Lentivirus, Modified Herpes Simplex Virus, and Pseudorabies Virus. The protocol is often performed in conjunction with the headbar implantation protocol (dx.doi.org/10.17504/protocols.io.bcrsiv6e). Please refer to the headbar implantation protocol for more details.
Controls of event-based nutrient transport within nested headwater agricultural watersheds of the western Lake Erie basin (2018)

Abstract Understanding the processes controlling nutrient delivery in headwater agricultural watersheds is essential for predicting and mitigating eutrophication and harmful algal blooms in receiving surface waters. The objective of this study was to elucidate nutrient transport pathways and examine key components driving nutrient delivery processes during storm events in four nested agricultural watersheds (298–19,341 ha) in the western Lake Erie basin with poorly drained soils and an extensive artificial drainage network typical of the Midwestern U.S. Concentration-discharge hysteresis patterns of nitrate-nitrogen (NO3-N), dissolved reactive phosphorus (DRP), and particulate phosphorus (PP) occurring during 47 storm events over a 6 year period (2004–2009) were evaluated. An assessment of the factors producing nutrient hysteresis was completed following a factor analysis on a suite of measured environmental variables representing the fluvial and wider watershed conditions prior to, and during the monitored storm events. Results showed the artificial drainage network (i.e., surface tile inlets and subsurface tile drains) in these watersheds was the primary flow pathway for nutrient delivery to streams, but nutrient behavior and export during storm events was regulated by the flow paths to and the intensity of the drainage network, the availability of nutrients, and the relative contributions of upland and in-stream nutrient sources. Potential sources and flow pathways for transport varied among NO3-N, PP, and DRP with results underscoring the challenge of mitigating nutrient loss in these watersheds. Conservation practices addressing both nutrient management and hydrologic connectivity will likely be required to decrease nutrient loss in artificially drained landscapes.
Table S2 from Radiomics, Tumor Volume, and Blood Biomarkers for Early Prediction of Pseudoprogression in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibition (2023)

&lt;p&gt;Summary of patient outcome of the individual groups (with landmark analysis) The landmark method was applied, that is all events before 5 months were excluded. 95% confidence intervals were provided in parentheses. PP-only patients were the best performing group, with a similar outcome compared to responding patients. TPD-only patients presented a significantly worse OS of 10 vs. 30 months in the PP-only group (p=0.002, FWER=0.010). Patients with mixed PP&amp;TPD were in between both other groups.&lt;/p&gt;
Absolute Structures of New Megastigmane Glycosides, Foliasalaciosides E1, E2, E3, F, G, H, and I from the Leaves of Salacia chinensis (2008)

Following the investigation of foliasalaciosides A(1), A(2), B(1), B(2), C, and D, seven new megastigmane glycosides named foliasalaciosides E(1)-I (1-7), together with four known constituents, were isolated from the leaves of Salacia chinensis LINN. collected in Thailand. The absolute stereostructures of the new compounds were characterized on the basis of chemical and physicochemical evidence, including the application of the modified Mosher's method.
An association between migraine and cutaneous allodynia (2000)

Recent animal studies on the mechanism of migraine show that intracranial pain is accompanied by increased periorbital skin sensitivity. These findings suggest that the pathophysiology of migraine involves not only irritation of meningeal perivascular pain fibers but also a transient increase in the responsiveness (ie, sensitization) of central pain neurons that process information arising from intracranial structures and skin. The purpose of this study was to determine whether the increased skin sensitivity observed in animal also develops in humans during migraine attacks. Repeated measurements of mechanical and thermal pain thresholds of periorbital and forearm skin areas in the absence of, and during, migraine attacks enabled us to determine the occurrence of cutaneous allodynia during migraine. Cutaneous allodynia is pain resulting from a nonnoxious stimulus to normal skin. In 79% of the patients, migraine was associated with cutaneous allodynia as defined, and in 21% of the patients it was not. The cutaneous allodynia occurred either solely within the referred pain area on the ipsilateral head, or within and outside the ipsilateral head. Cutaneous allodynia in certain well-defined regions of the skin during migraine is an as yet unreported neurological finding that points to hyperexcitability of a specific central pain pathway that subserves intracranial sensation.
From Patches to Honey-Patches (2014)

Traditional software security patches often have the unfortunate side-effect of quickly alerting attackers that their attempts to exploit patched vulnerabilities have failed. Attackers greatly benefit from this information; it expedites their search for unpatched vulnerabilities, it allows them to reserve their ultimate attack payloads for successful attacks, and it increases attacker confidence in stolen secrets or expected sabotage resulting from attacks. To overcome this disadvantage, a methodology is proposed for reformulating a broad class of security patches into honey-patches - patches that offer equivalent security but that frustrate attackers' ability to determine whether their attacks have succeeded or failed. When an exploit attempt is detected, the honey-patch transparently and efficiently redirects the attacker to an unpatched decoy, where the attack is allowed to succeed. The decoy may host aggressive software monitors that collect important attack information, and deceptive files that disinform attackers. An implementation for three production-level web servers, including Apache HTTP, demonstrates that honey-patching can be realized for large-scale, performance-critical software applications with minimal overheads.
Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues (2000)

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a major metabolite of the tobacco-specific lung carcino- gen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNAL has a chiral center at the 1-position, but little is known about the stereochemical aspects of its metabolic formation from NNK or its further metabolism. We investigated the metabolism of NNK to enantiomers of NNAL in microsomes and cytosol from male F-344 rat liver and lung, female A/J mouse liver and lung, and human liver, as well as in red blood cells from rats, mice and humans. In all systems, (S)-NNAL was the predominant enantiomer formed, ranging from 90 to 98% in the rodent tissues and averaging 64, 90 and >95% in human liver microsomes, liver cytosol and red blood cells, respectively. In rat liver microsomes, (R)- and (S)-NNAL were metabolized at similar rates by alpha-hydroxylation, considered to be the major metabolic activation pathway of NNAL. Pyridine-N-oxidation and adenosine dinucleotide phosphate adduct formation also occurred at similar rates from both enantiomers, while reoxidation to NNK was favored with (S)-NNAL as substrate. In rat lung microsomes, (S)-NNAL was more rapidly metabolized than (R)-NNAL by all oxidative pathways. In human liver microsomes, there were no significant differences in the rates of alpha-hydroxylation, pyridine-N-oxidation and reoxidation to NNK between the two enantiomers. The results of this study demonstrate that (S)-NNAL, the more tumorigenic enantiomer in mice, is preferentially formed from NNK in rodent and human tissues, and is a substrate for oxidative metabolism in rodent and human tissue microsomes.
Oligometastatic Disease in the Liver: The Role of Interventional Oncology (2022)

Oligometastatic disease represents a clinically discrete intermediate stage of cancer progression and is an expanding area of research. While surgical metastatectomy has been recognized for decades as an effective treatment option in select patients, options for metastasis-directed therapy have broadened in scope with advancements in the armamentarium of non- and minimally invasive modalities. Recent preclinical studies investigating the immunology surrounding liver metastases demonstrate treatment resistance to immunotherapy in affected patients and show how locoregional therapy has the ability to overcome this resistance. In this paper, we review advancements in our understanding of oligometastatic disease, metastasis-directed therapy, effect of liver metastasis on response to immunotherapy, and the burgeoning role of image-guided interventions in complementing cancer immunotherapy at the exciting crossroads of interventional oncology and immuno-oncology.
Incidence, clearance, persistence and factors related with high-risk anal HPV persistence in South-East Asian MSM and transgender women (2020)

HIV-positive MSM and TGW had higher risk of persistent anal HR-HPV infection. Prevention program should be made available and prioritized for HIV-positive MSM and TGW where resources are limited.
Wide-Scale Adoption of Photovoltaic Energy: Grid Code Modifications Are Explored in the Distribution Grid (2015)

Current grid standards largely require that low-power (e.g., several kilowatts) single-phase photovoltaic (PV) systems operate at unity power factor (PF) with maximum power point tracking (MPPT), and disconnect from the grid under grid faults by means of islanding detection. However, in the case of wide-scale penetration of single-phase PV systems in the distributed grid, disconnection under grid faults can contribute to 1) voltage flickers, 2) power outages, and 3) system instability. This article explores grid code modifications for a wide-scale adoption of PV systems in the distribution grid. In addition, based on the fact that Italy and Japan have recently undertaken a major review of standards for PV power conversion systems connected to low-voltage networks, the importance of low voltage ride-through (LVRT) for single-phase PV power systems under grid faults is considered, along with three reactive power injection strategies. Simulations are presented for a PV power system with a LVRT capability and ancillary services. An example of a full-bridge single-phase grid connected system is tested experimentally to demonstrate the potential benefits. Additionally, grid codes for advanced PV systems with the discussed features are summarized.
Area-efficient CMOS charge pumps for LCD drivers (2003)

Area-efficient 4× charge pumps based on the cross-coupled structure that uses the V/sub dd/-2V/sub dd/ outputs alternately to reduce the number of power devices and capacitors are presented. Compared with conventional designs, our best design can save two power transistors, one capacitor, and two level shift circuits. An integrated 4× charge pump is then designed to deliver 100 μA at 9 V using a 0.8-μm AMS high-voltage CMOS process. The topology can be extended to 2n× charge pumps, and a 6× charge pump is also fabricated and tested to demonstrate the validity of the extension.
A Conceptual Review On Strategic Human Resources Management And Planning In Non Profit Motive Organization (2018)

The nonprofit and public sectors are facing significant numbers of impending retirements from the traditionalists and baby boomers in their workforces. In an effort to retain the knowledge base of an agency or to better serve its clients, some organizations have developed creative ways to encourage retirement-eligible employees to remain on the job. Public and nonprofit organizations are driven by the knowledge and skills their employees possess. It is shortsighted for elected officials, board members, funders, executives, and other agency leaders to dismiss the importance of SHRM. As important, organizations must reinforce the importance of human capital and the contribution that knowledge management makes to the effective delivery of services.
Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem–like Cells in an Akt/Foxo3a/TRAIL–Dependent Manner (2015)

Self-renewing colorectal cancer stem/progenitor cells (CSC) contribute to tumor maintenance and resistance to therapy. Therapeutic targeting of CSCs could improve treatment response and prolong patient survival. ONC201/TIC10 is a first-in-class antitumor agent that induces TRAIL pathway-mediated cell death in cancer cells without observed toxicity. We have previously described that ONC201/TIC10 exposure leads to transcriptional induction of the TRAIL gene via transcription factor Foxo3a, which is activated by dual inactivation of Akt and ERK. The Akt and ERK pathways serve as important targets in CSCs. Foxo3a is a key mediator of Akt and ERK-mediated CSC regulation. We hypothesized that the potent antitumor effect of ONC201/TIC10 in colorectal cancer involves targeting CSCs and bulk tumor cells. ONC201/TIC10 depletes CD133(+), CD44(+), and Aldefluor(+) cells in vitro and in vivo. TIC10 significantly inhibits colonosphere formation of unsorted and sorted 5-fluorouracil-resistant CSCs. ONC201/TIC10 significantly reduces CSC-initiated xenograft tumor growth in mice and prevents the passage of these tumors. ONC201/TIC10 treatment also decreased xenograft tumor initiation and was superior to 5-fluorouracil treatment. Thus, ONC201/TIC10 inhibits CSC self-renewal in vitro and in vivo. ONC201/TIC10 inhibits Akt and ERK, consequently activating Foxo3a and significantly induces cell surface TRAIL and DR5 expression in both CSCs and non-CSCs. ONC201/TIC10-mediated anti-CSC effect is significantly blocked by the TRAIL sequestering antibody RIK-2. Overexpression of Akt, DR5 knockdown, and Foxo3a knockdown rescues ONC201/TIC10-mediated depletion of CD44(+) cells and colonosphere inhibition. In conclusion, ONC201/TIC10 is a promising agent for colorectal cancer therapy that targets both non-CSCs and CSCs in an Akt-Foxo3a-TRAIL-dependent manner.