gebhart/patrepeval huggingface dataset:
Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1 (2021)

Protein N-terminal methyltransferases (NTMTs) catalyze the methylation of the α-N-terminal amines of proteins starting with an X-P-K/R motif. NTMT1 has been implicated in various cancers and in aging, implying its role as a potential therapeutic target. Through structural modifications of a lead NTMT1 inhibitor, <b>BM30</b>, we designed and synthesized a diverse set of inhibitors to probe the NTMT1 active site. The incorporation of a naphthyl group at the N-terminal region and an <i>ortho</i>-aminobenzoic amide at the C-terminal region of <b>BM30</b> generates the top cell-potent inhibitor <b>DC541</b>, demonstrating increased activity on both purified NTMT1 (IC<sub>50</sub> of 0.34 ± 0.02 μM) and the cellular α-N-terminal methylation level of regulator of chromosome condensation 1 (RCC1, IC<sub>50</sub> value of 30 μM) in human colorectal cancer HT29 cells. Furthermore, <b>DC541</b> exhibits over 300-fold selectivity to several methyltransferases. This study points out the direction for the development of more cell-potent inhibitors for NTMT1.
Interactive tangible objects as play pieces in a digital tabletop game (2007)

In this paper we present a new type of tangible interface for a digital tabletop game. This interface consists of an interactive tangible object; a play piece representing a bridge in the game ‘Weathergods’ [1]. The game players can not only physically change the appearance of the bridge to manipulate the digital world, the digital world in return can also affect the appearance of this play piece.
Exploring the Feasibility of Electrostatic Shielding for Spacecrafts (2005)

NASA is moving forward towards the agency's new vision for space exploration in the 21st Century encompassing a broad range of human and robotic missions including missions to Moon, Mars and beyond. Exposure from the hazards of severe space radiation in deep space long duration missions is the show stopper. Langley has developed state-of-the-art radiation protection and shielding technology for space missions. The payload penalty demands a very stringent requirement on the design of the spacecrafts for human deep space missions. The exploration beyond low Earth orbit (LEO) to enable routine access to more interesting regions of space will require protection from the hazards of the accumulated exposures of space radiation, Galactic Cosmic Rays (GCR) and Solar Particle Events (SPE), and minimizing the production of secondary radiation is a great advantage. There is a need to look to new horizons for newer technologies. The present investigation explores the feasibility of using electrostatic shielding in concert with innovative materials shielding and protection technologies. The asymmetries of the radiation shielding problem would be exploited in the electrostatics shielding process. The goal is to repel enough positive charge ions so that they miss the spacecraft without attracting thermal electrons. Conclusions are drawn about the advantages the electrostatic shielding, should it be successful, would bring to the radiation protection design process.
Rapid electrofocusing of erythrocyte acid phosphatase (1984)

Abstract A routine method is described for obtaining reproducible erythrocyte acid phosphatase patterns by ultrathin‐layer polyacrylamide gel isoelectric focusing. Electrofocusing of EAP on 0.2 mm thick gels took 30 and 22 min on the Ultrophor and Cold Focus Apparatus, respectively, when the distance separating the electrodes was 5.4 cm. This method, which reduces the cost for focusing EAP, can be ideal for many laboratories interested in EAP phenotyping.
Mechanism of ozonolysis. New route to ozonides (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of ozonolysis. New route to ozonidesRobert W. Murray and Akio. SuzuiCite this: J. Am. Chem. Soc. 1973, 95, 10, 3343–3348Publication Date (Print):May 1, 1973Publication History Published online1 May 2002Published inissue 1 May 1973https://pubs.acs.org/doi/10.1021/ja00791a044https://doi.org/10.1021/ja00791a044research-articleACS PublicationsRequest reuse permissionsArticle Views207Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Site-controlled formation of InGaAs quantum nanostructures-Tailoring the dimensionality and the quantum confinement (2013)

We report on InGaAs quantum disks (QDks) controllably formed on the top (001) facet of nano-patterned GaAs pyramidal platforms. The QDks exhibit pyramidal shape with special facets and varied dimensions, depending on the GaAs pyramidal buffer and the amount of InGaAs deposited. The formation of QDks is explained by the overgrowth of an InGaAs layer and thereafter coalescence of small InGaAs islands. Photoluminescence (PL) characteristics of ensemble QDks and exciton features of individual QDks together demonstrate that we may achieve a transition from zero-dimensional (0D) to two-dimensional (2D) quantum structure with increasing QDk size. This transition provides the flexibility to continuously tailor the dimensionality and subsequently the quantum confinement of semiconductor nanostructures via site-controlled self-assembled epitaxy for device applications based on single quantum structures.
Three Pulsars with Marching Subpulses (1970)

High time-resolution studies of individual pulses from the pulsars MP 0031, CP 0808, and CP 0834 reveal subpulse structures which systematically march across the average pulse window from one pulse to the next. It is shown that periodic fluctuations in pulse intensities are manifestations of the same phenomenon.
ChemInform Abstract: Efficient Synthesis of Carbovir and Its Congener via π‐ Allylpalladium Complex Formation by Ring Strain‐Assisted C‐N Bond Cleavage. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The effects of wire diameter and an additional lateral wire on pin and tension-band fixation subjected to cyclic loads (2006)

Despite reports of frequent complications, pin and tension- band wire remains the most common repair of simple olecranon fractures and osteotomies. A recent mechanical study found wire diameter to be the key determinant of pin and tension-band construct strength; models with 1.25-mm wire were much stronger than those with standard 1.0-mm wire exposed to single loads to failure. Additionally, fixation strength was also increased when a lateral wire was used in combination with a standard figure-of-eight wire. The purpose of the present study was to assess any advantages provided by 1.25-mm wire or an additional lateral wire over 1.0-mm wire for pin and tension-band fixation subjected to cyclic loading. Pin and tension-band fixation was applied to plastic olecranon osteotomy models with three wire configurations: 1.0-mm figure-of-eight, 1.25-mm figure-of-eight, and combined 1.0-mm figure-of-eight and lateral. Cyclic load was applied while caudal osteotomy displacement was measured with an extensometer. The three groups were compared in terms of cycles to failure, mean minimum displacement, mean maximum displacement, and mean displacement per cycle. Models with an additional lateral wire survived significantly more cycles than those with a solitary 1.0-mm figure-of-eight wire, although caudal osteotomy displacements were not significantly different. Conversely, models with 1.25-mm wire allowed significantly smaller minimum and maximum displacements than those with 1.0-mm wire, but did not survive significantly more cycles. It therefore appears that clinical use of 1.25-mm wire may improve stability, while use of an additional lateral wire may improve durability.
Safety and Efficacy of Microfocused Ultrasound in Tightening of Lax Elbow Skin (2015)

This pilot study suggests that MFU-V is a safe and promising nonsurgical option for the treatment of skin laxity above the elbow. Based on the positive results of this study, a larger trial is warranted together with testing different treatment densities to optimize this noninvasive approach.
Improving Nickel Exploration using a Purposefully Designed Airborne Electromagnetic System, with an Example from Julimar, Western Australia (2023)

Nickel (NiS) exploration is well suited for geophysical methods; nickel sulphides are generally dense, very electrically conductive and chargeable. In particular, electromagnetic methods are suitable because of a very large conductivity contrast between nickel sulphides and host rocks. The extreme conductivity of massive NiS can cause the decay constant of a potential resource to be very large (Smiarowski and Macnae, 2013), necessitating low-base frequency or ground EM surveys. Ground EM surveys can be time-consuming, very costly, and suffer in difficult to access terrain. In the last 5 years, advances in receiver suspension and receiver construction have made airborne electromagnetic low-base frequency operation possible and greatly improved the ability to explore for NiS. We discuss the changes made to the Xcalibur Helitem, helicopter time domain EM, system to enable low base frequency operation at 6.25 Hz. We then show an example of a low base frequency Helitem survey targeting Nickel performed in the Julimar Region of Western Australia. Of particular interest is the detection of anomalous conductivity outside of the magnetic extent of the Julimar Complex.
Risk Assessment for Polycyclic Aromatic Hydrocarbon NAPLs Using Component Fractions (1999)

Polycyclic aromatic hydrocarbons (PAHs) are important environmental contaminants because of their suspected carcinogenicity. PAH contamination is often found in the form of nonaqueous phase liquids (NAPLs), such as coal tar. These materials are very complex mixtures with the constituent compounds exhibiting a wide range of chemical, physical, and toxicological properties. This makes it difficult to characterize a PAH NAPL and predict its behavior. Lumped metrics, such as total petroleum hydrocarbons (TPH), are often used to specify remediation goals at PAH NAPL sites, but these metrics do not capture the variation in NAPL composition over time and as such do not consider changes in risk over time. This paper presents an alternative method for characterizing PAH NAPLs that is based on the fraction approach developed by the Total Petroleum Hydrocarbon Criteria Working Group (TPHCWG). The fraction approach characterizes the PAH NAPL as a collection of U.S. EPA Priority Pollutants plus hydrocarbon fractions. This approach allows prediction of the NAPL compositional dynamics while retaining some of the simplified analysis of a lumped parameter approach. The fractions and priority pollutants are modeled as NAPL components for performing risks assessments and assessing the potential of remediation strategies. This makes the fraction approach amenable for use in a Risk-Based Corrective Action (RBCA) framework. In this work, the TPHCWG fraction approach was modified for description of NAPL constituents that are solids in their pure states. This was accomplished by assigning an equivalent solid−liquid reference fugacity ratio for each fraction. Thirty-year simulations with two model coal tars are presented, comparing the risk calculations for the fraction approach to those accounting for the complete NAPL composition. These simulations show that the model using the fraction approach predicts similar NAPL compositional dynamics and PAH carcinogenic risk as the model describing all the compounds. Use of the fraction approach at PAH NAPL sites will allow a more accurate accounting of the risk variation than the TPH approach. Additionally, it will emphasize development and use of remediation methods that address risk reduction, not just the reduction in total contaminant mass.
Treatment of infected retained implants (2005)

We have prospectively studied the outcome of infections associated with implants which were retained and treated using a standardised antimicrobial protocol. Over a period of four years, we studied 24 consecutive patients who had symptoms of infection for less than one year, a stable implant, no sinus tract and a known pathogen which was susceptible to recommended antimicrobial agents. The infections involved hip prostheses (14), knee prostheses (5), an internal fixation device (4), and an ankle prosthesis (1). Twenty patients had a successful outcome at a median follow-up of 3.7 years (1.8 to 4.7); four had failure of the implant after a median follow-up of 1.2 years (0.3 to 2.5). The probability of survival without failure of treatment was 96% at one year (95% confidence interval (CI) 88 to 100), 92% at two years (95% CI 80 to 100) and 86% at three years (95% CI 72 to 100). Patients with a short-term infection but with a stable implant, no sinus tract and a known pathogen may be successfully treated by retention of the implant and the use of a standardised regimen of antimicrobial treatment.
ChemInform Abstract: Ruthenium meso‐Tetrakis(2,6‐dichlorophenyl)porphyrin Complex Immobilized in Mesoporous MCM‐41 as a Heterogeneous Catalyst for Selective Alkene Epoxidations. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lightpath Rerouting Strategies in WDM All-Optical Networks Under Scheduled and Random Traffic (2010)

International audience
Optical Measurement Techniques: Fundamentals and Applications (2011)

This chapter contains sections titled: Introduction Light Scattering and Extinction Theory Dynamic Light Scattering Experimental Methods for the Laboratory Optical Measurement Techniques: Ex Situ Sensing Optical Measurement Techniques: In Situ Sensing Conclusions List of Symbols References
Annexe III Liste des éditions du De regimine principum de Gilles de Rome (2011)

This appendix of the book contains a list of publications of De Regimine Principum of Giles of Rome. This book deals with the different translations into Old French of Giles of Rome's De Regimine Principum (1279) and their readership. It establishes a census of all the manuscripts containing a French translation of the Treaty of Giles of Rome. For each of them, particular attention has been paid to the various elements (materials, shapes, production sites, reading marks, brands possession) that allow one to reconstruct their history. The purpose of this book is, on the basis of a review of manuscripts, to place the different French translations in their general context and understand the historical and social conditions of their transmission and dissemination. For that purpose, one can consider the manuscript in both its material and intellectual dimension. The original text of the chapter is in French.Keywords: De regimine principum; Giles of Rome; Old French; readership; translations
Excimer-Mediated Intermolecular Charge Transfer in Self-Assembled Donor–Acceptor Dyes on Metal Oxides (2019)

When conjugate molecules are self-assembled on the surface of semiconductors, emergent properties resulting from the electronic coupling between the conjugate moieties are of importance in the interfacial electron-transfer dynamics for photoelectrochemical and optoelectronics devices. In this work, we investigate the self-assembly of triphenylamine-oligothiophene-perylenemonoimide (PMI) molecules, denoted as BH4, on metal oxide surfaces via UV-vis absorption, photoluminescence, and transient near-infrared absorption spectroscopies and molecular dynamics simulations, and we report the excimer formation due to the π-π interaction of the PMI units between the neighboring dye molecules. To our best knowledge, this is the first experimental observation of intermolecular excimer formation when conjugate donor-acceptor molecules form a self-assembled monolayer. In addition, a long-lived (4.3 μs) intermolecular charge separation is observed, and a new excimer-mediated intermolecular charger-transfer mechanism is proposed. This work demonstrates that, through the design of dye molecules, the excited complexes or aggregates can provide a pathway to slow down the recombination rate in photoelectrodes that utilize donor-acceptor dyad molecules.
Effect of Cation Substitution on Bipolar Resistance Switching Behavior in Epitaxially Grown NiO Films (2010)

Epitaxial NiO films (epi-NiO) were successfully doped with Al by performing sequential deposition of NiO and AlO x by pulsed laser deposition. Surface morphology and crystallinity were confirmed by atomic force microscope images and X-ray diffraction, indicating that the samples were grown epitaxially. Resistance switching (RS) phenomena of Al-doped NiO films were investigated using epitaxial SrRuO 3 (SRO) and CaRuO 3 (CRO) as the bottom (BE) and top electrode (TE), respectively. When the epi-NiO/SRO interface was modified by inserting either a 1-nm-thick epitaxial AlO x layer or a 5-nm-thick epitaxial 10% Al-doped NiO (Al 0.1 Ni 0.9 O x ) layer, the RS of epi-NiO remained unchanged. However, when the CRO/epi-NiO interface was modified by inserting a 1-nm-thick epitaxial AlO x layer or a 5-nm-thick Al 0.1 Ni 0.9 O x layer, switching behavior was significantly changed; in the case of the 1-nm-thick epitaxial AlO x layer, the switching behavior completely disappeared, while in the case of 5-nm-thick Al 0.1 Ni 0.9 O x layer, number of cells which exhibited RS was drastically decreased. The switching phenomena may be suppressed due to the presence of Al cations whose free energy for oxidation is much lower than that of Ni. Our experimental results suggest that oxygen ions migration at the TE/epi-NiO interface may play a critical role in bipolar RS of epi-NiO. The relation between RS and free energy for oxidation is discussed.
Introduzione. L'inattualità della televisione (2009)

con cambiamenti o adeguamenti tecnologici, abbiamo assistito all'enunciazione di ci che sembra l'inevitabile destino di un mezzo ritenuto ormai obsoleto, che lascer (o avrebbe gi dovuto lasciare) il posto a mezzi pi dinamici, personalizzati, che superino definitivamente la trasmissione broadcasting.E, proprio in questi giorni, stiamo assistendo all'ennesima riflessione in tal senso, in concomitanza anche stavolta con un adeguamento tecnologico: il cosiddetto switch off, cio il passaggio al digitale terrestre di tutta la televisione italiana -processo che altri stati hanno ormai effettuato da anni e ormai metabolizzato.Cito al proposito alcuni brani tratti da un recente articolo, intitolato "Televisione.I nuovi bisogni dello spettatore in frantumi", di Edmondo Berselli su La Repubblica (19 novembre 2009, pp.
Gradient - An Adaptive Fault-tolerant Routing Algorithm for 2D Mesh Network-on-Chips (2012)

International audience
ChemInform Abstract: BIOLOGICALLY ACTIVE CYCLOPEPTIDES‐ LYSINE ANALOGS OF POLYMYXINS ANTIBIOTICS M, D, E AND B (1977)

Abstract Die Cyclisierung der Heptapeptide (I) bis (IV) gelingt am besten mit Äthoxyacetylen und Anwendung der p‐Nitrophenyl‐Methode.
Distance aware collision avoidance protocol for ad-hoc underwater acoustic sensor networks (2007)

This paper proposes a channel access protocol for ad-hoc underwater acoustic networks which are characterized by long propagation delays and unequal transmit/receive power requirements. The protocol saves transmission energy by avoiding collisions while maximizing throughput. It is based on minimizing the duration of a hand-shake by taking advantage of the receiver's tolerance to interference when the two nodes are closer than the maximal transmission range. Nodes do not need to be synchronized, can move, are half-duplex, and use the same transmission power. This protocol achieves a throughput several times higher than that of the slotted FAMA, while offering similar savings in energy. Although carrier sensing ALOHA offers a higher throughput, it wastes much more power on collisions.
Supplementary Table 5 from Large-scale Transcriptome Analyses Reveal New Genetic Marker Candidates of Head, Neck, and Thyroid Cancer (2023)

Supplementary Table 5 from Large-scale Transcriptome Analyses Reveal New Genetic Marker Candidates of Head, Neck, and Thyroid Cancer
Correlations of SELENOF and SELENOP genotypes with serum selenium levels and prostate cancer (2018)

These results indicate an interaction between selenium status and selenoprotein genotypes that may contribute to the disparity in prostate cancer incidence and outcome experienced by African Americans.
PATHOGEN FATE IN WASTEWATER SOIL ABSORPTION SYSTEMS AS AFFECTED BY EFFLUENT QUALITY AND SOIL CLOGGING GENESIS (2013)

Over 25% of the US population and 37% of all new development is served by onsite and smallscale wastewater systems, the majority of which rely on percolation of primary treated effluentthrough soil to achieve purification prior to recharge to the ground water. Attempts to exploit thebenefits of decentralized system approaches have resulted in innovations in design approaches andtechnologies that are emerging at a growing rate. In some cases, modifications to historicalpractice are warranted and supported by a sound scientific and engineering foundation. In others,design practice has evolved ahead of the knowledge needed to support such change. One suchsituation concerns the trend where wastewater soil absorption systems (WSAS) are being designedutilizing a higher level of pretreatment than provided by the common septic tank (e.g., sand filteror constructed wetland) to enable elevated hydraulic loading rates and smaller soil treatmentsystems (either in infiltration area or depth of vadose zone soil). These practices may be soundbased on hydraulics, but purification of contaminants of concern, especially pathogenic bacteriaand virus has not been proven. This paper discusses the need for a more fundamentalunderstanding of the fate and transport of pathogens in WSASs. The relationship betweenhydraulic loading rate and quality of applied effluent and their effect on pathogen purificationperformance is required to utilize soil-aquifer systems effectively while preventing drinking watercontamination.
Resin adhesion to caries‐affected dentine after different removal methods (2006)

Besides the differences in adhesives, different caries removal methods seem to influence resin adhesion to caries-affected dentine.