gebhart/patrepeval huggingface dataset:
Electrophosphorescence from a Polymer Guest–Host System with an Iridium Complex as Guest: Förster Energy Transfer and Charge Trapping (2003)

Abstract We report high‐efficiency green electrophosphorescent light‐emitting diodes obtained by using tris[9,9‐dihexyl‐2‐(phenyl‐4′‐(‐pyridin‐2″‐yl))fluorene]iridium( III ) (Ir(DPPF) 3 ) as the guest, and a blend of poly(vinylcarbazole) (PVK) with 2‐ tert ‐butylphenyl‐5‐biphenyl‐1,3,4‐oxadiazol (PBD) as the host. The electrophosphorescent emission is characteristic of Ir(DPPF) 3 , with its maximum at 550 nm. An external quantum efficiency of 8 % photons per electron and luminous efficiency of 29 cd A –1 , with maximum brightness of 3500 cd m –2 , were achieved at 1 wt.‐% concentration of Ir(DPPF) 3 . The devices exhibited no emission from PVK or PBD, even at the lowest concentration of Ir(DPPF) 3 (0.1 wt.‐%). The results indicate that Förster energy transfer plays a minor role in achieving high efficiencies in these devices. Direct charge trapping appears to be the main operating mechanism.
Mutual privacy-preserving regression modeling in participatory sensing (2013)

As the advancement of sensing and networking technologies, participatory sensing has raised more and more attention as it provides a promising way enabling public and professional users to gather and analyze private data to understand the world. However, in these participatory sensing applications both data at the individuals and analysis results obtained at the users are usually private and sensitive to be disclosed, e.g., locations, salaries, utility usage, consumptions, behaviors, etc. A natural question, also an important but challenging problem is how to keep both participants and users data privacy while still producing the best analysis to explain a phenomenon. In this paper, we have addressed this issue and proposed M-PERM, a mutual privacy preserving regression modeling approach. Particularly, we launch a series of data transformation and aggregation operations at the participatory nodes, the clusters, and the user. During regression model fitting, we provide a new way for model fitting without any need of the original private data or the exact knowledge of the model expression. To evaluate our approach, we conduct both theoretical analysis and simulation study. The evaluation results show that the proposed approach produces exactly the same best model as if the original private data were used without leakage of the fitted model to any participatory nodes, which is a significant advance compared with the existing approaches [1-5]. It is also shown that the data gathering design is able to reach maximum privacy protection under certain conditions and be robust against collusion attack. Furthermore, compared with existing works under the same context (e.g., [1-5]), to our best knowledge it is the first work showing that not only the model coefficients estimation but also a series of regression analysis and model selection methods are reachable in mutual privacy preserving data analysis scenarios such as participatory sensing.
Effects of single-base substitutions within the Acanthamoeba castellanii rRNA promoter on transcription and on binding of transcription initiation factor and RNA polymerase I. (1988)

Single-point mutations were introduced into the promoter region of the Acanthamoeba castellanii rRNA gene by chemical mutagen treatment of a single-stranded clone in vitro, followed by reverse transcription and cloning of the altered fragment. The promoter mutants were tested for transcription initiation factor (TIF) binding by a template commitment assay plus DNase I footprinting and for transcription by an in vitro runoff assay. Point mutations within the previously identified TIF interaction region (between -20 and -47, motifs A and B) indicated that TIF interacts most strongly with a sequence centered at -29 and less tightly with sequences upstream and downstream. Some alterations of the base sequence closer to the transcription start site (and outside the TIF-protected site) also significantly decreased specific RNA synthesis in vitro. These were within the region which is protected from DNase I digestion by polymerase I, but these mutations did not detectably affect the binding of polymerase to the promoter.
A New Biocatalyst for Production of Optically Pure Aryl Epoxides by Styrene Monooxygenase from Pseudomonas fluorescens ST (1999)

We developed a biocatalyst by cloning the styrene monooxygenase genes (styA and styB) from Pseudomonas fluorescens ST responsible for the oxidation of styrene to its corresponding epoxide. Recombinant Escherichia coli was able to oxidize different aryl vinyl and aryl ethenyl compounds to their corresponding optically pure epoxides. The results of bioconversions indicate the broad substrate preference of styrene monooxygenase and its potential for the production of several fine chemicals.
Shigella dysenteriae I enterotoxin: proposed role in pathogenesis of shigellosis (1980)

Bacterial strains of Shigella dysenteriae I (3818-T and 3818-O) and Shigella enterotoxin altered myoelectric activity of the small intestine in New Zealand White rabbits. These agents were compared with activity caused by sterile culture broth or sterile saline. The altered myoelectric activity was characterized by two distinct complexes: repetitive bursts of action potentials (RBAP), characteristic of invasive strains of bacteria, and the migrating action potential complex (MAPC), characteristic of noninvasive bacteria. RBAP activity was the predominant myoelectric complex observed with S. dysenteriae strain 3818-T, an invader and toxin producer; S. dysenteriae strain 3818-O, a noninvader and toxin producer; and by Shigella enterotoxin. MAPC activity was present but was significantly less in all cases. These studies of the small intestine demonstrate an alteration in myoelectric activity characterized principally by RBAP activity indicative of invasion.
Apelin Enhances the Effects of Fusobacterium nucleatum on Periodontal Ligament Cells In Vitro (2023)

This study aimed to explore effects of <i>Fusobacterium nucleatum</i> with or without apelin on periodontal ligament (PDL) cells to better understand pathomechanistic links between periodontitis and obesity. First, the actions of <i>F. nucleatum</i> on COX2, CCL2, and MMP1 expressions were assessed. Subsequently, PDL cells were incubated with <i>F. nucleatum</i> in the presence and absence of apelin to study the modulatory effects of this adipokine on molecules related to inflammation and hard and soft tissue turnover. Regulation of apelin and its receptor (APJ) by <i>F. nucleatum</i> was also studied. <i>F. nucleatum</i> resulted in elevated COX2, CCL2, and MMP1 expressions in a dose- and time-dependent manner. Combination of <i>F. nucleatum</i> and apelin led to the highest (<i>p</i> < 0.05) expression levels of COX2, CCL2, CXCL8, TNF-α, and MMP1 at 48 h. The effects of <i>F. nucleatum</i> and/or apelin on CCL2 and MMP1 were MEK1/2- and partially NF-κB-dependent. The combined effects of <i>F. nucleatum</i> and apelin on CCL2 and MMP1 were also observed at protein level. Moreover, <i>F. nucleatum</i> downregulated (<i>p</i> < 0.05) the apelin and APJ expressions. In conclusion, obesity could contribute to periodontitis through apelin. The local production of apelin/APJ in PDL cells also suggests a role of these molecules in the pathogenesis of periodontitis.
Atopy, Asthma, and Emphysema in Patients with Severe α -1-Antitrypysin Deficiency (1997)

Bronchial asthma is characterized by episodic airway obstruction and associated with wheezing, a bronchodilator response, an elevation in total serum IgE, and atopy. To determine whether asthma is more common in subjects with severe alpha 1-antitrypsin deficiency (alpha 1-ATD) and airway obstruction, we compared 38 patients who had this condition (Group 1) with 22 control patients with chronic obstructive pulmonary disease (COPD) (Group 2) and with five subjects with alpha 1-ATD and normal spirometry (Group 3). Subjects were evaluated with a symptom questionnaire, pulmonary function testing, intradermal allergen testing, and serum IgE measurement. Self-reported wheezing was a common symptom in all patient groups, but attacks of wheezing with dyspnea were significantly more common in Group 1. Of those patients with airway obstruction, more than 50% showed a bronchodilator response whether suffering from alpha 1-ATD or not. Atopy was more common in Group 1 than in Group 2 (48% versus 27%). Mean serum IgE for all groups was similar but significantly greater in patients with atopy. We estimated the prevalence of asthma in the study groups on the basis of the criteria of attacks of wheezing, reversible airway obstruction, atopy, and that increased IgE. The proportion of patients with asthma in Group 1 was significantly greater than that in Group 2 (22% versus 5%, p < 0.05). Our study shows that with control for the degree of airway obstruction, asthma, as defined, is more common in patients with alpha 1-ATD than in those without it. We suggest that a lack of alpha 1-AT in airways increases the propensity to develop asthma.
Fast rotor flux control of direct-field-oriented induction motor operating at maximum efficiency using adaptive rotor flux observer (2002)

A method of using an adaptive rotor flux observer to rapidly control the rotor flux of direct-field-oriented induction motors driven by a deadbeat rotor flux controller has been developed. The method ensures maximum efficiency in the steady state without degradation of the dynamic response. Furthermore, to solve the problem of flux current variations that arise from small errors in the measurement of the stator voltage and current, a flux current reference is calculated from the appropriate rotor flux in the steady state. Simulation and experimental results for an induction motor have demonstrated that this method yields the maximum efficiency and good speed response to changes in both torque and motor speed without any degradation in the transient characteristics.
Ribosome regulation by the nascent peptide (1996)

Studies of bacterial and eukaryotic systems have identified two-gene operons in which the translation product of the upstream gene influences translation of the downstream gene. The upstream gene, referred to as a leader (gene) in bacterial systems or an upstream open reading frame (uORF) in eukaryotes, encodes a peptide that interferes with a function(s) of its translating ribosome. The peptides are therefore cis-acting negative regulators of translation. The inhibitory peptides typically consist of fewer than 25 residues and function prior to emergence from the ribosome. A biological role for this class of translation inhibitor is demonstrated in translation attenuation, a form or regulation that controls the inducible translation of the chloramphenicol resistance genes cat and cmlA in bacteria. Induction of cat or cmlA requires ribosome stalling at a particular codon in the leader region of the mRNA. Stalling destabilizes an adjacent, downstream mRNA secondary structure that normally sequesters the ribosome-binding site for the cat or cmlA coding regions. Genetic studies indicate that the nascent, leader-encoded peptide is the selector of the site of ribosome stalling in leader mRNA by cis interference with translation. Synthetic leader peptides inhibit ribosomal peptidyltransferase in vitro, leading to the prediction that this activity is the basis for stall site selection. Recent studies have shown that the leader peptides are rRNA-binding peptides with targets at the peptidyl transferase center of 23S rRNA. uORFs associated with several eukaryotic genes inhibit downstream translation. When inhibition depends on the specific codon sequence of the uORF, it has been proposed that the uORF-encoded nascent peptide prevents ribosome release from the mRNA at the uORF stop codon. This sets up a blockade to ribosome scanning which minimizes downstream translation. Segments within large proteins also appear to regulate ribosome activity in cis, although in most of the known examples the active amino acid sequences function after their emergence from the ribosome, cis control of translation by the nascent peptide is gene specific; nearly all such regulatory peptides exert no obvious trans effects in cells. The in vitro biochemical activities of the cat/cmla leader peptides on ribosomes and rRNA suggest a mechanism through which the nascent peptide can modify ribosome behavior. Other cis-acting regulatory peptides may involve more complex ribosomal interactions.
Evolutionary analysis and distribution of type III effector genes in pathogenic Escherichia coli from human, animal and food sources (2010)

Molecular analysis of Shiga toxin-producing Escherichia coli (STEC) from different sources is considered as a major approach to assess their risk potential. However, only limited data are available about the correlation of evolutionary relationship, the presence of major virulence factor genes and the putative risk of an STEC strain for human infection. In this study, we analysed the evolutionary relationship of 136 pathogenic E. coli strains from human, animal and food sources by multi-locus sequence typing (MLST) and molecular subtyping of their Shiga toxin (stx) and intimin (eae) genes. Moreover, the distribution of three type III effector genes, encoded within the locus of enterocyte effacement (LEE), and 16 effector genes, which are encoded outside the LEE, was analysed. One hundred and five strains from different sources harboured 5-15 of the analysed non-LEE-encoded effector genes. In 101 of these strains, the LEE genes eae, map, espF and espG were present simultaneously. Thirty-one isolates deriving mainly from food and patients suffering from haemolytic uraemic syndrome (HUS) were eae-negative and did not carry any of the analysed effector genes. By combination of MLST and virulence gene data, we defined five genetic clusters. Within these clusters a clear-cut affiliation of particular sequence types and the occurrence of certain effector genes was observed. However, in contrast to other studies, a significant correlation between the amount and type of effector genes and the risk to cause HUS could not be demonstrated.
Evaluation of the film and adhesive properties of some block copolymer polyhydroxypolyamides from esterified aldaric acids and diamines (2000)

A number of structurally different block copolymer polyhydroxypolyamides (PHPAs), produced by condensation polymerization of activated aldarates with 1o diamines, were evaluated for their water and methanol solubility and film-forming and adhesive properties. The polymers are composed of a single aldaric acid and a single diamine unit, a single aldaric acid and two diamine units, two aldaric acids and a single diamine unit, or two aldaric acids and two diamine units. The aldaryl monomer units in the polymers were derived from D-glucaric, xylaric, and galactaric (mucic) acids. A number of alkylenediamines and heteroatom (oxygen and nitrogen)-containing diamines were employed as comonomers. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 77: 3085–3092, 2000
Binge Alcohol Intake After Hypergravity Stress Sustainably Decreases AMPK and Transcription Factors Necessary for Hepatocyte Survival (2016)

These results show that binge alcohol exposure in mice immediately following a +9 Gz hypergravity stress persistently decreased AMPKα and other key molecules required for hepatocyte survival, and these changes may be reversed by repetitive hypergravity loads.
TMT - A TLB Tag Management Framework for Virtualized Platforms (2009)

The rise in multi-core architectures has led to the abundance of computing resources on a chip. Virtualization has emerged as a way to efficiently partition and share these resources. Thus, the emphasis in micro-architecture design, especially in ×86, has shifted towards providing hardware support for better performance of VMs on bare metal. One of the areas of focus for these efforts is the Translation Lookaside Buffer (TLB). Recent modifications in the TLB include the addition of tags as a part of the TLB entry and the incorporation of hardware primitives to perform tag comparison during TLB lookup. In this paper we present the Tag Manager Table (TMT), a low-latency management architecture for tagging the TLB entries using process-specific identifiers (based on the CR3 register in ×86), and thereby reducing the number of flushes and the miss rate in the TLB. Using a full system simulation approach, we investigate the performance benefit of these tags and explore how it varies with the size of the TMT, the TLB architecture and the workload characteristics. We also perform a sensitivity analysis and quantify the relative importance of all these factors in determining the benefit from CR3 tagging. While our focus is on virtualized platforms, this approach is equally applicable for non virtualized environments.
Nano-materials for adhesive-free adsorbers for bakable extreme high vacuum cryopump surfaces (2023)

A cryosorber panel having nanomaterials used for the cryosorption material, with nanomaterial either grown directly on the cryopanel or freestanding nanomaterials attached to the cryopanel mechanically without the use of adhesives. Such nanomaterial cryosorber materials can be used in place of conventional charcoals that are attached to cryosorber panels with special low outgassing, low temperature capable adhesives. Carbon nanotubes and other nanomaterials could serve the same purpose as conventional charcoal cryosorbers, providing a large surface area for cryosorption without the need for adhesive since the nanomaterials can be grown directly on a metallic substrate or mechanically attached. The nanomaterials would be capable of being fully baked by heating above 100.degree. C., thereby eliminating water vapor from the system, eliminating adhesives from the system, and allowing a full bake of the system to reduce hydrogen outgassing, with the goal of obtaining extreme high vacuum where the pump can produce pressures below 1.times.10.sup.-12 Torr.
Optimization of a Renewable Energy Supply System on a Remote Area: Berlenga Island Case Study (2011)

HOMER software was used to technical and economically assess two renewable energy supply (RES) system configurations -PV-only (80 kW) and PV (34 kW)/WT (36 kW), both with a three day storage capacity and requiring 11kW of electric power -proposed by a partnership project responsible for the implementation of sustainable measures on a Portuguese small island.HOMER calculation showed insufficient storage capacity for both RES system proposed, so extra storage capacity should be added.Economically, life cycle cost (NPC) of the cheaper configuration (PV/WT) resulting from HOMER calculation was significantly lower (20%) than the one advanced by the project.On a second stage, HOMER was used to compute an optimal RES system configuration to attend water desalination and street lighting electric additional loads.The optimal configuration -PV (25 kW)/WT (18kW) -costs 18% less than the equivalent PV/WT system proposed by the project when the same additional load is considered.Sensitivity analysis on the electric load showed the cost difference between project's and HOMER's proposals fading as the load increased.Variation on wind speed average demonstrated the significance of data accuracy: using NASA's average wind speed data the NPC increased on 15% compared to using wind speed values revealed on a monitoring campaign on the island.
Synthetic aperture LADAR techniques (2012)

Synthetic Aperture Ladar (SAL) system performance is generally limited by the chirp ranging sub-system. Use of a high bandwidth linearized chirp laser centered at 1.55 microns enables high resolution ranging. Application of Phase Gradient Autofocus (PGA) to high resolution, stripmap mode SAL images and the first demonstration of Interferometric SAL (IFSAL) for topography mapping are shown in a laboratory setup with cross range resolution commensurate with the high range resolution. Projective SAL imaging is demonstrated as a proof of concept. Finally spotlight mode SAL in monostatic and bistatic configurations is explored.
FATE (2012)

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The tumor suppressive role of PRMT6 in regulating the pathogenesis of hepatocellular carcinoma (2015)

This journal suppl. entitled: Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA
Inhibition of Histone Deacetylase Class I but not Class II Is Critical for the Sensitization of Leukemic Cells to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis (2006)

From work done largely on derived cell lines, it has been suggested that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) might be a therapeutic target for many forms of malignancy. However, use of primary tumor cells, including chronic lymphocytic leukemic (CLL) cells, has shown inherent resistance to TRAIL. Although the molecular basis for this resistance remains unknown, treatment with histone deacetylase inhibitors (HDACi) often sensitizes resistant cells to TRAIL-induced apoptosis. We used structurally diverse HDACi to ascertain which HDAC needs to be inhibited for the sensitization. Inhibition of HDAC class I but not class II is required for sensitization to TRAIL-induced apoptosis of CLL cells and various cell lines. Using different HDACi together with small interfering RNA for HDAC1, HDAC2, HDAC3, and HDAC6, we report that inhibition of HDAC1 and HDAC2 but not HDAC3, HDAC6, and HDAC8 are primarily responsible for sensitization to TRAIL-induced apoptosis. Based on these data and our previous studies, we propose that a clinical trial in CLL is warranted using a combination of a selective HDACi that inhibits HDAC1 and/or HDAC2 together with a form of TRAIL that signals through TRAIL receptor 1.
Studies on Vitamin B<sub>1</sub> and Related Compounds. XXXIII (1952)

An Attempt was made to utilize the decomposition of thiaminase by sulfurous acid for the synthesis of allied compounds but it could not be made successfully. For example, reaction of N-benzylpyridinium chloride and aniline, in the presence of sulfurous acid, failed to yield the desired N-benzylaniline. Reaction of N-[2′-amino-4′-hydroxypteridyl-(6′)]-methyl-4-methyl-5-β-hydroxyethylthiazolium iodide and N-(p-aminobenzoyl)-glutamic acid, in the presence of sulfurous acid, also failed to give any indication of the formation of folic acid. Therefore, the relationship between this decomposition reaction and chemical structure was examined, and as a result, it was found that compounds in which the 2-position of the pyrimidine nucleus is substituted with ethyl radical (III) or the 4-position with methylamino radical (II) are decomposed almost similar to the case of thiamine (I), but that hydroxythiamines are not decomposed at all. In this case, the amino radical at 4-position has an important significance. Compounds in which the thiazole nucleus is substituted with methyl (IX), ethyl (X) or carbethoxyl (XI) in the 5 position, are also decomposed, the decomposition being promoted by the addition of aniline. However, the compounds in which the pyrimidine nucleus has been substituted with nitrobenzyl (VI), (VII), (VIII), or in which the thiazole nucleus has been substituted with benzothiazole (XII) are entirely indifferent to the decomposition.The effect of the addition of thiamine analogs during this reaction to the decomposition of thiamine was examined from which it was learned that nitrobenzyl homologs (VI), (VII), (XIV) and 2′-methyl-4′-aminopyrimidyl homologs (XI) and (XVI) tended to inhibit decomposition, while o-aminobenzyl homologs (XIII) and (XV), and benzothiazole homologs (XII) promoted decomposition. Hydroxythiamine (IV) seemed to give no effect.