gebhart/patrepeval huggingface dataset:
Quantitative Trait Loci Controlling Resistance to Gray Leaf Spot in Maize (1993)

Gray leaf spot (GLS) (caused Cercospora zeae‐maydis Theon &amp; Daniels) is a fungal disease of the maize ( Zea mays L.) that can cause significant grain yield reductions. Quantitative resistance to GLS does exist; therefore, one method of controlling the disease is to develop hybrids with genetic resistance. The objective of this study was to identify quantitative trait loci (QTL) and type‐of‐gene action for GLS resistance in segregating families of three single‐cross populations of maize using restriction fragment length polymorphisms (RFLPs). We also attempted to determine the consistency of QTL over environments and populations. Population 1 (POP1) consisted of 139 F 2:3 families evaluated in three environments. Population 2 (POP2) consisted 193 F 2:3 families and Population 3 (POP3) had 144 F 2:3 families; POP2 and POP3 were considered as replicate populations evaluated in separate environments. Families were rated for GLS on a plot basis by a scale of 1 (susceptible) to 9 (resistant), and ratings were taken at 5‐ to 18‐d intervals in each environment. The QTL were identified on the basis of marker associations with GLS means over all ratings taken in an environment, as well as a GLS mean over environments for POP1 and over POP2 and POP3 for the replicate populations. Based on single‐factor ANOVA, detectable individual markers accounted for 4 to 26% of the phenotypic variation. The QTL associated with GLS were inconsistent over environments, but the cause of these differences could not be determined. One region on chromosome 2 was associated with GLS resistance in POP1, POP2, and POP3. Additive gene action was displayed for nearly all markers associated with resistance.
A systematic review of the current evidence regarding interventions for anxiety, PTSD, sleepiness and fatigue in the law enforcement workplace (2019)

Law enforcement is inherently stressful, and police officers are particularly vulnerable to mental and physical disorders. As such, researchers are currently assessing intervention strategies that may combat or manage these psychological, physical and mental issues. To review most recent information regarding anxiety, PTSD, and sleepiness and fatigue and identify the interventions and treatments proposed to overcome work related stressors and associated mental illnesses inflicting law enforcement officers. The EMBASE, OVID MEDLINE and PsycINFO databases were canvassed for articles investigating anxiety, post-traumatic stress disorder, sleepiness, and fatigue. Initial article selections were made based on title, whilst final inclusion was informed by a full critical appraisal with respect to the primary and secondary effects. The systematic search returned 363 records, of which 183 were unique. Following screening, 43 records were included in the final review. The included literature assessed the efficacy of several interventions, and provided a number of recommendations regarding interventions, and policy. Moreover, literature indicates that police officers benefit from interventions targeting work-related stress and potential psychological disorders, if these interventions are continuous. Furthermore, larger controlled studies are required to further elucidate the benefits of psychosocial intervention in law enforcement.
EBNA3C Attenuates the Function of p53 through Interaction with Inhibitor of Growth Family Proteins 4 and 5 (2010)

Epstein-Barr virus (EBV)-encoded EBNA3C is one of the latent proteins essential for the efficient transformation of human primary B lymphocytes into continuously proliferating lymphoblastoid cell lines (LCLs) in vitro through manipulation of a number of major cellular pathways. Although it does not have direct DNA-binding activity, EBNA3C plays a central role in the transcriptional modulation of a wide range of both viral and cellular genes during latent infection. Recently, we showed that EBNA3C can directly bind to the tumor suppressor protein p53 and repress its functions, in part by blocking its transcriptional activity as well as facilitating its degradation through stabilization of its negative regulator, Mdm2. In this study, we further showed that EBNA3C can negatively regulate p53-mediated functions by interacting with its regulatory proteins, the inhibitor of growth family proteins ING4 and ING5, shown to be frequently deregulated in different cancers. Functional mapping revealed that both ING4 and ING5 bound to N-terminal domain residues 129 to 200 of EBNA3C, which was previously demonstrated to associate with p53 and is also essential for LCL growth. In addition, we showed that a conserved domain of either ING4 or ING5 bound to both p53 and EBNA3C in a competitive manner, suggesting a potential role for EBNA3C whereby the ING4 or -5/p53 pathway is modulated in EBV-infected cells. Subsequently, we demonstrated that EBNA3C significantly suppresses both the ING4- and ING5-mediated regulation of p53 transcriptional activity in a dose-dependent manner. A colony formation assay as well as an apoptosis assay showed that EBNA3C nullified the negative regulatory effects on cell proliferation induced by coupled expression of p53 in the presence of either ING4 or ING5 in Saos-2 (p53(-/-)) cells. This report demonstrates a possible role for the candidate tumor suppressor ING genes in the biology of EBV-associated cancers.
Effect of Intramammary Dry Cow Antimicrobial Treatment on Fresh Cow’s Milk Microbiota in California Commercial Dairies (2022)

This study used 16S rRNA sequencing to evaluate the effects of dry cow antimicrobial therapy on the udder milk microbiota by comparing the microbial populations in milk at dry-off (DRY) (~60 days before calving) and post-partum (FRESH) (4-11 days after calving) from cows receiving an intramammary antibiotic infusion prior to dry-off (IMT) and cows that did not receive treatment (CTL). Milk was collected from 23 cows from the IMT group and 27 cows from the CTL group. IMT and DRY samples had a greater correlation with the genera <i>Brevibacterium</i> and <i>Amaricoccus</i>, and the family Micrococcaceae, when compared to IMT and FRESH samples. CTL group samples collected at DRY had a greater correlation with the genera <i>Akkermansia</i> and <i>Syntrophus,</i> when compared to FRESH samples; no bacterial taxa were observed to have a significant correlation with FRESH samples in the CTL group. DRY samples collected from the CTL group had a greater correlation with the genus <i>Mogibacterium</i> when compared to IMT and CTL samples. For DRY samples collected from the IMT group, a greater correlation with the genus <i>Alkalibacterium</i> when compared to DRY and CTL samples, was observed. The lack of a correlation for FRESH samples between the CTL and IMT treatment groups indicated that intramammary antimicrobial dry cow therapy had no significant effect on the udder milk microbiota post-partum.
Decentralized Blended Acquisition - Are Networks the Next Big Step in Seismic Data Collection? (2013)

Until today, seismic acquisition is carried out with a centralized architecture, the collected information being linear in the number of detectors (N). In the last decades N has been continuously increased, making seismic acquisition systems very complex. It is proposed to break this trend by abandoning the traditional centralized acquisition concept. Instead, it is proposed to concentrate future developments on the promises offered by the network architecture, showing a quadratic behavior in seismic information (N^2). By moving from a single complex, centralized system to a network of simple, decentralized subsystems, robotization becomes a very attractive proposition.
METHOD FOR ADAPTIVE MESH GENERATION BASED ON GEOMETRICAL FEATURES OF 3D SOLID (2006)

为了提供指导指定元素，在适应有限元素网孔产生期间动态地缩放，适应标准第一根据在几何特征和 3D 固体的元素之间的关系被定义。各种各样的模式基于不同资料，几何元素例如顶点，弯，等等，表面然后为产生本地精制网孔被设计。与定义标准的指导，不同模式自动地被选择在适当资料目标上适用编程序在本地特殊区域的元素尺寸。作为结果，元素尺寸的控制信息成功地被规划基于 3D 固体的几何特征盖住全部域。基于的 onDelaunay 三角测量当时是的一个新算法为产生适应有限元素网孔，元素尺寸在是动态地指定了抓住几何特征的 3D 发展了，合适的四面体方面被选择连续地定位内部节点。作为结果，适应网孔 withgood 质量元素被产生。例子证明建议方法能成功地被用于适应有限元素网孔自动产生基于 3Dsolid 的几何特征。
A thermodynamic basis for the electronic properties of molten semiconductors: the role of electronic entropy (2016)

The thermodynamic origin of a relation between features of the phase diagrams and the electronic properties of molten semiconductors is provided. Leveraging a quantitative connection between electronic properties and entropy, a criterion is derived to establish whether a system will retain its semiconducting properties in the molten phase. It is shown that electronic entropy is critical to the thermodynamics of molten semiconductor systems, driving key features of phase diagrams including, for example, miscibility gaps.
A synthesis of enantiomerically enriched propargyl silanes (1998)

Reduction of ethyl 3-methyl-, 3-isopropyl- and 3-n-pentyl-3-[dimethyl(phenyl)silyl]propanoates 4 with DIBAL to the aldehydes 5, enol trifluoromethanesulfonate (triflate) formation using trifluoromethanesulfonic (triflic) anhydride and 2,6-di-tert-butylpyridine, and elimination using LDA, gives the propargyl silanes 8. The esters 4 could also be prepared enantiomerically enriched (11), and the final products are the enantiomerically enriched propargyl (homochiral) silanes 14.
Influence of the Injection Pressure on the Combustion Performance and Emissions of Small GDI Engine Fuelled with Bio-Ethanol (2011)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Non-intrusive measurements were carried out in an optical spark ignition GDI engine in order to characterize the chemical and physical processes involved using gasoline and bio-ethanol fuel. In particular, an optical 4 strokes small single cylinder engine for two wheel vehicles was used. It was equipped with an elongated piston with a wide sapphire window in the head and quartz cylinder. Exhaust emissions and engine performances were evaluated during the imaging and spectral measurements in order to investigate the spray characteristics and flame propagation with high spatial and temporal resolution. Several engine conditions based on homogeneous charge mixture conditions were investigated considering the effect of injection pressure and ethanol fuel too. The simultaneous use of the high injection pressure and bio-ethanol showed to be a valid answer to reduction of pollutants without worsening the performances.&lt;/div&gt;&lt;/div&gt;
Defect induced ferromagnetic ordering in epitaxial Zn 0.95 Mn 0.05 O films on sapphire (0 0 0 1) (2019)

We report the influence of Mn dopant on magnetic properties of Zn<sub>0.95</sub>Mn<sub>0.05</sub>O (ZMO)/Al<sub>2</sub>O<sub>3</sub>(0 0 0 1) hetero-epitaxial systems grown by using pulsed-laser deposition. The room temperature (RT) intrinsic ferromagnetic (FM) ordering verified by superconducting quantum interference device magnetometer and x-ray magnetic circular dichroism spectrum of Mn L <sub>2,3</sub> edges is ascribed to the substitutional Mn atoms in the Zn site of ZnO. Mn in ZMO has a tetrahedral local symmetry instead of the octahedral symmetry of MnO, after verifying the absence of the Mn-related impurities or clusters in ZMO epitaxial film by Mn K-edge and Zn K-edge x-ray absorption spectroscopy spectrum, as well as the analysis of long-range structural ordering on Renninger scan of forbidden (0 0 0 5) reflection in x-ray diffraction, transmission electron microscopy and Raman spectrum. Comparison of x-ray absorption spectra of ZMO with those of ZnO epilayers at O K-, Zn K-, and L <sub>3</sub>-edges indicates that the substitution of the Zn site with Mn enhances the charge-transfer (CT) transition and the presence of Zn vacancies (V<sub>Zn</sub>) also dominate the photoluminescence (PL) spectrum, implying that the formation of numerous V<sub>Zn</sub> defects plays an important role in activating FM interactions. The strong CT effect and the existence of high-density V<sub>Zn</sub> suggest that the intrinsic RT FM ordering of insulating ZMO is a result of the formation of the bound magnetic polarons (BMPs) that interact with each other via intermediate magnetic impurities.
Advances in Agrochemicals: Ion Channels and G Protein-Coupled Receptors (GPCRs) as Targets for Pest Control (2017)

An expanding and often upwardly mobile global population requires large improvements in the quantity and quality of food production as well as freedom from the ravages of disease carrying insect vectors. This necessitates that new options and approaches for insect control be developed. Increasing pest resistance to existing insecticides, a changing regulatory landscape, and shifts in pest spectrum due to changes in climate and agronomic practices, including transgenic plants, all present challenges to developing new insect control agents. The agrochemical industry has been developing synthetic organic insecticide solutions to insect pest problems for more than 70 years. Early efforts produced just a few insecticide classes/modes of action (MoA), each with a large number of different active ingredients. More recent industry efforts have been focused on an increasingly diverse array of insecticide classes, most often coupled to new or underexploited MoAs, but with each class having only a few members. A wide range of approaches have been and continue to be employed in the discovery of these more recent commercial offerings as well as the insecticides currently under development. In spite of the decline in the number of agrochemical companies in the US, EU and Asia that are now involved in insecticide discovery, innovative solutions continue to be found. Powered by the availability of new research tools and an increase in the size of many of the remaining agrochemical companies, robust discovery platforms are being built which will provide additional novel insect control products in the future.
Quantitative Concentration Mapping with AFM-SECM (2020)

Efficient transport of reaction intermediates between active sites can improve the efficiency of multi-site reactions 1–3 . Experimental detection of these nanometer length scale transport mechanisms is enabled by Scanning Electrochemical Microscopy (SECM). Electrochemical measurements can allow for concentration profile mapping to elucidate the transport processes in experimental systems. SECM can correlate position dependent responses to properties of the system. There is a significant impact on the response profile due to the SECM tip’s presence at the nanoscale. Finite Element Analysis (FEA) has been used to understand and remove these in situ tip effects. The calculated concentration, using current-flux relations, can be complex near sites generating flux through reactions and/or transport. Additionally, uncertainties such as tip positioning in relation to the interface site can further complicate the response. Quantitative concentration fields can more readily be interpreted through FEA, by matching the experimental tip response. Electrodeposited platinum nanoparticles were imaged topographically and electrochemically with a Bruker AFM-SECM (Figure 1). The positive response over the nanoparticles vs. the planar HOPG sites allows for kinetic response imaging. The model is parameterized through approach curves and verified though SECM mapping correlation. We have previously applied FEA to correlate experimental in situ results to in operando conditions. Here, we use this approach to generate corrected concentration profiles. We use Pt nanoparticle catalysts deposited on HOPG, to develop surface property correlations. In this way, a comparison can be drawn between in situ and in operando approaches. References (1) Schuhmann, W. Amperometric Enzyme Biosensors Based on Optimised Electron-Transfer Pathways and Non-Manual Immobilisation Procedures. Rev. Mol. Biotechnol. 2002 , 82 (4), 425–441. (2) Wheeldon, I.; Minteer, S. D.; Banta, S.; Barton, S. C.; Atanassov, P.; Sigman, M. Substrate Channelling as an Approach to Cascade Reactions. Nat. Chem. 2016 , 8 (4), 299–309. (3) Liu, Y.; Hickey, D. P.; Guo, J. Y.; Earl, E.; Abdellaoui, S.; Milton, R. D.; Sigman, M. S.; Minteer, S. D.; Calabrese Barton, S. Substrate Channeling in an Artificial Metabolon: A Molecular Dynamics Blueprint for an Experimental Peptide Bridge. ACS Catal. 2017 , 7 (4), 2486–2493. Figure 1
Dynamic testing of ADCs using wavelet transforms (2002)

This paper introduces a new method for evaluating non-idealities in ADCs using wavelet transforms. Compared with conventional testing methods, this method can shorten the test time and improve test quality during production testing of ADCs.
Dermatological infections in the immunocompromised host (1998)

The data from the most recent studies concerning infection with human herpes virus 8 strongly support a pathogenic role for this virus in the tumoral hyperplasia which is a feature of Kaposi's sarcoma. The results from the first studies of the sensitivity of human herpes virus 8 to antiviral drugs were also published last year. This review also concerns bacterial and mycobacterial infections showing unusual presentation, important trials in the prevention of infection with varicella zoster virus by using vaccination in children with leukemia, and a controlled therapeutic study in HIV-infected patients presenting with early syphilis.
Cerebrospinal fluid analysis in 108 patients with progressive multifocal leukoencephalopathy (2020)

This comprehensive, retrospective study on CSF diagnostic analysis in PML patients provides insight into the CSF of those patients. It demonstrates that CSF composition in PML patients may be specific for the underlying condition that predisposes for the development of PML and thus data have to be interpreted in this context.
Ecdysone agonists - mechanism of action and application onSpodopteraspecies (1999)

Laboratory assays using artificial diet demonstrated that tebufenozide (RH-5992) and the new structural analogue, RH-2485 (proposed common name methoxyfenozide), possess strong ecdysone-like activity against last-instar larvae of the beet armyworm, Spodoptera exigua, and the cotton leafworm, Spodoptera littoralis, leading to precocious lethal moulting. LC50 values showed that the activity of RH-2485 (0.38 mg AI litre−1) was about twice that of tebufenozide (0.60 mg AI litre−1) in S. exigua, whereas in S. littoralis respective LC50 values were 1.15 mg AI litre−1 and 9.51 mg AI litre−1. The retention-fate curves of 14C-radiolabelled ecdysone agonist could not explain the differential toxicity values between species and compounds. Ingestion of the oxidase inhibitor piperonyl butoxide (PB) synergized the toxicity of the ecdysone agonist, indicating the importance of oxidative detoxifcation in Spodoptera larvae, and may raise the possible use of PB as synergist for this group of insecticides, or for monitoring resistance due to increased oxidation. © 1999 Society of Chemical Industry
High-level synthesis of an enhanced Connex memory (2002)

Architectural deficiencies in symbolic processing systems are generated by the lack of an appropriate implementation of their memory functions. There are many well-defined memory functions, but there isn't yet an adequate structural implementation for any of them. The main memory functions are usually software implemented as data structures, using RAM as hardware support, but having low performance in applications because all implementations rely on sequential mechanisms. The Connex Memory (CM), involves a base-level structural parallelism that would increase the performance in tree/list processing. This paper is concerned with the synthesis of an enhanced version of CM. Specific applications of the CM include list processing, set operations, string matching and Prolog-like computation.
French neonatal society position paper stresses the importance of an early family‐centred approach to discharging preterm infants from hospital (2019)

Discharge preparations may improve the transition from hospital to home and the outcomes for the parents and newborn preterm infant. This early family-centred approach should be structured, coordinated and based on individual needs and circumstances.
Ellagitannins and Complex Tannins from Quercus petraea Bark (1994)

The ellagitannins 2,3-(S)-hexahydroxydiphenoyl-glucose, pedunculagin, vescalagin, and castalagin; the flavanoellagitannins acutissimin A, acutissimin B, eugenigrandin A, guajavin B, and stenophyllanin C; and the procyanidinoellagitannin mongolicanin have been isolated from the bark of Quercus petraea. The ellagitannin fraction had a weak antisecretory effect.
Mechanism of action of des-His1-[Glu9]glucagon amide, a peptide antagonist of the glucagon receptor system. (1993)

We have investigated the mechanisms through which des-His1-[Glu9]glucagon amide functions as a peptide antagonist of the glucagon receptor/adenylyl cyclase system. Studies with radiolabeled peptides identified that (i) the antagonist bound to intact hepatocytes according to a single first-order process, whereas the rate of association of glucagon with the same preparation could be described only by the sum of two first-order processes; (ii) the interaction of the antagonist with saponin-permeabilized hepatocytes was not affected by the addition of GTP to the incubation medium or by the elimination of Mg2+, whereas the interaction of glucagon with the same cell preparation was modified significantly by the presence of the nucleotide or by the absence of the divalent metal ion; (iii) the dissociation of antagonist from intact hepatocytes incubated in buffer was complete, whereas that of agonist was not; and (iv) the antagonist bound to intact hepatocytes at steady state according to a single binding isotherm (as did both agonist and antagonist in permeabilized hepatocytes), whereas glucagon bound to the intact cell system with two clearly defined apparent dissociation constants. A model is presented for the mechanism of action of the glucagon antagonist in which the analog binds to glucagon receptors in a Mg(2+)- and GTP-independent fashion and in which resulting ligand-receptor complexes fail to undergo sequential adjustments necessary for the stimulation of adenylyl cyclase.
1.3-&lt;tex&gt;$mu$&lt;/tex&gt;m Uncooled DFB Laser-Diode Module With a Coupled Differential Feed for 10-Gb/s Ethernet Applications (2004)

A coaxial 10-Gb/s 1.3-/spl mu/m distributed feedback (DFB) laser-diode module with a coupled differential feed has been developed. The differential cascaded feed with the characteristic impedance of 100 /spl Omega/, which consists of a 140-/spl Omega/ ground-signal-signal-ground (GSSG) leads, a small-sized 60-/spl Omega/ feed-through, and a 140-/spl Omega/ wire-bonding pad, provides less sensitivity to the lead length. Integrating with 25-/spl Omega/ matching resistances and a 60-/spl Omega/ differential microstrip line, whose length corresponds to one eighth of wavelength at 7 GHz, gives wide-band impedance matching between the feed and the laser diode portion with small power loss. Experiment shows good return loss of greater than 9 dB at 10 GHz, and small change of bit error rate (BER) up to the lead length of 4 mm. With a newly developed 250-/spl mu/m cavity laser chip, we have demonstrated stable eye diagrams with the mask margins of 31 and 29% at case temperature of 0 and 85/spl deg/C, respectively.