gebhart/patrepeval huggingface dataset:
Using ellipsometry and x-ray photoelectron spectroscopy for real-time monitoring of the oxidation of aluminum mirrors protected by ultrathin MgF2 layers (2019)

To maintain high, broad-band reflectance, thin transparent fluoride layers, such as MgF2, are used to protect the of aluminum mirrors against oxidation since aluminum oxide absorbs short wavelength light. In this study, we present, for the first time, combined X-ray photoelectron spectroscopy (XPS) and ellipsometric (SE) studies of aluminum oxidation as a function of MgF2 over a range of layer thickness (0-6 nm). We also show for the first time, dynamic SE data which, with appropriate modeling, tracks the extent of oxide growth every few seconds over a period of several hours after the evaporated Al + MgF2 bilayer is removed from the deposition chamber, exposing it to the air. For each SE data set, because the optical constants of ultrathin metals films depend strongly on deposition conditions and their thickness, the optical constants for Al, as well as the Al and Al2O3 thicknesses, were fit. SE trends were confirmed by X-ray photoelectron spectroscopy. There is a chemical shift in the Al 2s electron emission peak toward higher binding energy as the metal oxidizes to Al+3. The extent of oxide growth can be modeled from the relative area of each peak once they are corrected for the attenuation through MgF2 layer. This generates an empirical formula: oxide thickness= k*log(t) +b, for the time-dependent aluminum-oxide thickness on aluminum surfaces protected by MgF2 as a function of MgF2 layer thickness. Here, k is a factor which depends only on MgF2 thickness, and decreases with increasing MgF2 thickness. The techniques developed can illuminate other protected mirror systems.
Iterative equalization and decoding with channel shortening filters for space-time coded modulation (2002)

We consider space-time trellis coded modulation in frequency selective channels. We discuss the outage capacity of space-time trellis coded modulation compared to the capacity of the underlying MIMO channel. Furthermore, we derive FIR channel shortening filters which are used as pre-filters for turbo equalization in order to reduce the number of equalizer states. We show that we can compensate for part of the performance loss due to channel shortening by turbo iterations and a transformation of time diversity to a form of spatial diversity.
Modeling of the structure in aqueous solution of the exopolysaccharide produced by Lactobacillus helveticus 766 (2001)

A method is described for constructing a conformational model in water of a heteropolysaccharide built up from repeating units, and is applied to the exopolysaccharide produced by Lactobacillus helveticus 766. The molecular modeling method is based on energy minima, obtained from molecular mechanics calculations of each of the constituting disaccharide fragments of the repeating unit in vacuo, as starting points. Subsequently, adaptive umbrella sampling of the potential of mean force is applied to extract rotamer populations of glycosidic dihedral angles of oligosaccharide fragments in solution. From these analyses, the most probable conformations are constructed for the hexasaccharide-repeating unit of the polysaccharide. After exploring the conformational space of each of the individual structures by molecular dynamics simulations, the different repeating unit conformations are used as building blocks for the generation of oligo- and polysaccharide models, by using a polysaccharide building program. The created models of the exopolysaccharide produced by L. helveticus 766 exhibit a flexible twisted secondary structure and tend to adopt a random coil conformation as tertiary structure.
The effects of modulation combination, target BER, Doppler frequency, and adaptation interval on the performance of adaptive OFDM in broadband mobile channel (2002)

OFDM is one of the promising modulation candidates for a fourth generation broadband mobile communication system because of its robustness against intersymbol interference (ISI). The adaptive modulation scheme is also an efficient scheme to increase the transmission rate by changing the channel modulation scheme according to the estimated channel state information. Since its implementation depends on the channel environment of the system and control period by using feedback information, this paper presents an evaluation for the effects of various modulation scheme combinations, target BER, Doppler frequency, and various adaptation intervals as control period on the performance of adaptive OFDM. We also propose a predicted feedback information scheme which increases the adaptation interval using the predicted power estimation in order to reduce the transmission time of feedback information from receiver to transmitter. Computer simulation results show that the case with BPSK, QPSK and 16QAM modulation combination at target BER 10/sup -2/ achieves 2Mbit/s improvement over other combination cases in high Doppler frequency. On the other hand, at target BER 10/sup -3/, the case with BPSK, QPSK, 8PSK and 16QAM modulation combination achieves 3Mbit/s improvement compared to the case of target BER 10/sup -2/. It is also shown that the predicted feedback information scheme effectively reduces the transmission time of feedback information from the receiver to transmitter.
Plantes de Nouvelle Calédonie, 109. Absouline, Alcaloïde Pyrrolizidinique Nouveau Isole de Hugonia oreogena et Hugonia penicillanthemum (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPlantes de Nouvelle Calédonie, 109. Absouline, Alcaloïde Pyrrolizidinique Nouveau Isole de Hugonia oreogena et Hugonia penicillanthemumKhalid Ikhiri, A. Ahond, C. Poupat, P. Potier, J. Pusset, and T. SévenetCite this: J. Nat. Prod. 1987, 50, 4, 626–630Publication Date (Print):July 1, 1987Publication History Published online1 July 2004Published inissue 1 July 1987https://pubs.acs.org/doi/10.1021/np50052a008https://doi.org/10.1021/np50052a008research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Complémentarité entre réseau véhiculaire et réseau LTE (2013)

International audience
Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression. (1993)

The ability of peroxisome proliferator-activated receptors (PPARs) to induce expression of a reporter gene linked to a peroxisome proliferator-responsive element (PPRE) from either the rat enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase gene or acyl-CoA oxidase [acyl-CoA:oxygen 2-oxidoreductase, EC 1.3.3.6] gene was examined by transient transfection assays in COS cells. Mouse and rat PPARs, as well as Xenopus PPAR alpha (xPPAR alpha) could induce expression of a reporter gene linked to the hydratase/dehydrogenase PPRE in the presence of the peroxisome proliferators ciprofibrate or Wy-14,643, whereas xPPAR beta and xPPAR gamma were ineffective. A similar induction of expression of a reporter gene linked to the acyl-CoA oxidase PPRE was observed with all PPARs except xPPAR beta. Extracts from cells transfected with PPAR-encoding genes contained factors that bound to both PPREs. In vitro synthesized PPARs could interact weakly with both PPREs; however, binding of each PPAR to both PPREs was significantly increased by the addition of COS cell nuclear extracts, demonstrating that efficient PPAR/DNA binding requires auxiliary cofactors. One cofactor was identified as the 9-cis-retinoic acid receptor, RXR alpha (retinoid X receptor alpha). Cooperative DNA binding and heteromerization between RXR alpha and each of the PPARs could be seen with both PPREs. Our results demonstrate that PPAR/PPRE binding and cooperativity with RXR alpha (and other cofactors) are obligatory but not necessarily sufficient for peroxisome proliferator-dependent transcription induction and that distinct PPREs can selectively mediate induction by particular PPARs.
Remote Plasma Device for Surface Modification at Atmospheric Pressure (2009)

Here, a novel atmospheric plasma device is presented, which applies the (remote) afterglow of micro-barrier discharges. The study evaluates its applicability to surface modification of temperature-sensitive particulates. As such, cylindrical samples have been placed in the remote treatment zone of the device, and the effects of treatment time and variable gas mixtures on the surface wettability are investigated. Furthermore, the influence of the excess voltage in He discharge with admixtures of O2, CO2 and N2 and the effect thereof on the water contact angle is described.
A Synthesis of a Spirocyclopropane-1,1'-carbapenem (1987)

The total synthesis of the spira~yclo~ropane 1,l'carbapenem 13 has been achieved through the Wittig cyclization of the phosphorane 11.A modified Simmons-Smith reaction on the olefinic ketone 5 gave the key cyclopropane derivative 1 in good yield.A recent report1 by Shih and ca-workers on the synthesie of 1-8-methylcarbapenems 1 which posses.much improved chemical and metabolic stability than 1-unsubstituted carbapenems has created considerable interest in the chemical modification of the carbapenem ring at the C-1 position of carbapenems.'~~~~i f i ~l l ~, this paper describes an efficient synthesis of a new carbapenem derivative having the cyclopropane ring attached at the C-1 position as depicted in the structure 2.-Hz, lH), 5.21 (d, J = 2.0 Hz, 1H), 5.28 (d, J -11.9 Hz, lH), 5.39 (d, J -2.0 Hz, lH), 5.43 (d.J = 11.9Hz, 1H).All other spectra data were in agreement with the proposed structure.
Differential Involvement of Initiator Caspases in Apoptotic Volume Decrease and Potassium Efflux during Fas- and UV-induced Cell Death (2001)

Caspase activation and apoptotic volume decrease are fundamental features of programmed cell death; however, the relationship between these components is not well understood. Here we provide biochemical and genetic evidence for the differential involvement of initiator caspases in the apoptotic volume decrease during both intrinsic and extrinsic activation of apoptosis. Apoptosis induction in Jurkat T lymphocytes by Fas receptor engagement (intrinsic) or ultraviolet (UV)-C radiation (extrinsic) triggered the loss of cell volume, which was restricted to cells with diminished intracellular K(+) ions. These characteristics kinetically coincided with the proteolytic processing and activation of both initiator and effector caspases. Although the polycaspase inhibitor benzyloxycarbonyl-Val-Ala-Asp fluoromethyl ketone completely inhibited the Fas-mediated apoptotic volume decrease and K(+) efflux, it was much less effective in preventing these processes during UV-induced cell death under conditions whereby caspase activities and DNA degradation were blocked. To define the roles of specific initiator caspases, we utilized Jurkat cells genetically deficient in caspase-8 or stably transfected with a dominant-negative mutant of caspase-9. The results show that the activation of caspase-8, but not caspase-9, is necessary for Fas-induced apoptosis. Conversely, caspase-9, but not caspase-8, is important for UV-mediated shrunken morphology and apoptosis progression. Together, these findings indicate that cell shrinkage and K(+) efflux during apoptosis are tightly coupled, but are differentially regulated by either caspase-8 or caspase-9 depending on specific pathways of cell death.
Differential expression of surface membrane growth hormone receptor on human peripheral blood lymphocytes detected by dual fluorochrome flow cytometry. (1994)

Although several reports indicate proliferative and functional effects of human GH (hGH) on peripheral blood lymphocytes (PBL), no information is available about hGH receptor (GHR) expression in PBL subsets. Here, the surface membrane GHR levels were investigated in different human PBL subpopulations using a fluorescein isothiocyanate (FITC)-conjugated monoclonal antibody specific for the GHR (mAb263) in dual fluorochrome flow cytometric assays. Strong GHR expression was found in B-cells (CD20+), whereas CD2+ lymphocytes, including T-cells as well as natural killer cells, exhibited considerably lower levels of receptor expression. Similarly, using FITC-labeled recombinant hGH, receptor expression on CD20+ cells was significantly higher than that on CD2+ cells. Abundant expression of GHR in B-lymphocytes was confirmed by reverse transcriptase-polymerase chain reaction analysis of GHR messenger ribonucleic acid from isolated B-cells. Accordingly, the B-cell merits greater consideration as a GH target cell. The use of FITC-labeled mAb263 and hGH is of potential use for the study of GHR levels in patients exhibiting different types of growth disorders. Because of its high specificity for GHR, FITC-labeled mAb263 is also of considerable value for specifically demonstrating the presence of GHR, because hGH may interact with and act through PRL receptor, as shown previously in human neutrophils.
Abstract 2241: SHH pathway in uterine mesenchymal tumors (2014)

Abstract Background: Uterine leiomyoma (ULM) and leiomyosarcoma (ULMS) are smooth muscle tumors with distinct clinical behavior that can cause infertility and even lead to death. Little is known about the factors that influence these tumors biology. Identification of new molecular markers can help in the differential diagnosis between ULM from low grade ULMS. It was demonstrated that activation of the Sonic Hedgehog (SHH) signaling pathway is related to the development of several tumors, through its activity in the cell proliferation and differentiation. Here, we investigated the protein expression profile of SHH, PTCH1, SMO and GLI1 both ULM (including non-typical leiomyomas) and ULMS. Methods: We selected 57 samples of ULMS and 30 samples of ULM (10 samples non-typical - ULMA). All tissues were used in TMA construction. Immunohistochemistry reaction was performed using monoclonal antibody against SHH (1:50), PTCH (1:100), SMO (1:100) and GLI-1 (1:200) using sodium citrate pH 6,0 in pressure cooker. Results were evaluated by Aperio® automated method. Results: Our preliminary data showed similar protein profile between the leiomyosarcoma and non-typical leiomyoma. GLI 1 and PTCH showed higher expression compared to leiomyoma and myometrium (p&amp;lt;0.05). SMO, and SHH showed higher expression only in leiomyossarcomas (p&amp;lt;0.05). Conclusions: Ours preliminary results showed that expression of Sonic Hedgehog pathway members might play an important role in uterine smooth tumors, since ULMS showed higher levels of these proteins. However, the role of these proteins interactions must be clarified. Citation Format: Natalia Garcia, Faila C. Souza, Nilo Bozzini, Glauco Baiocchi, Isabela W. Cunha, Fernando A. Soares, Edmund C. Baracat, Kátia C. Carvalho. SHH pathway in uterine mesenchymal tumors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2241. doi:10.1158/1538-7445.AM2014-2241
Assessment of Total and Free Mycophenolic Acid in Transplant Patient Plasma by Enzyme Receptor Assay (2005)

s: Ninth International Congress of Therapeutic Drug Monitoring and Clinical Toxicology: Louisville, Kentucky April 23-28, 2005
Late‐Stage Aryl C−H Bond Cyclopropenylation with Cyclopropenium Cations (2023)

Abstract Herein, we disclose the first regio‐, site‐ and chemoselective late‐stage (hetero)aryl C−H bond cyclopropenylation with cyclopropenium cations (CPCs). The process is fast, operationally simple and shows an excellent functional group tolerance in densely‐functionalized drug molecules, natural products, agrochemicals and fluorescent dyes. Moreover, we discovered that the installation of the cyclopropene ring in drug molecules could not only be used to shield against metabolic instability but also as a synthetic tool to reach medicinally‐relevant sp 3 ‐rich scaffolds exploiting the highly‐strained nature of the cyclopropene ring with known transformations.
Choosing a reference phase for a dynamic tumor tracking treatment: A new degree of freedom? (2019)

Although no general dependency of the applied dose on the selected reference phase could be found, the choice of the reference phase can have great impact on the organ at risk dose for some patients. Thus, the choice of the reference phase used for patient positioning should be considered during treatment planning since it can be seen as a new degree of freedom of a treatment based on tracking.
Regulation of Cholesterol Homeostasis and Lipid Metabolism in Skeletal Muscle by Liver X Receptors (2002)

Recent studies have identified the liver X receptors (LXRalpha and LXRbeta) as important regulators of cholesterol and lipid metabolism. Although originally identified as liver-enriched transcription factors, LXRs are also expressed in skeletal muscle, a tissue that accounts for approximately 40% of human total body weight and is the major site of glucose utilization and fatty acid oxidation. Nevertheless, no studies have yet addressed the functional role of LXRs in muscle. In this work we utilize a combination of in vivo and in vitro analysis to demonstrate that LXRs can functionally regulate genes involved in cholesterol metabolism in skeletal muscle. Furthermore we show that treatment of muscle cells in vitro with synthetic agonists of LXR increases the efflux of intracellular cholesterol to extracellular acceptors such as high density lipoprotein, thus identifying this tissue as a potential important regulator of reverse cholesterol transport and high density lipoprotein levels. Additionally we demonstrate that LXRalpha and a subset of LXR target genes are induced during myogenesis, suggesting a role for LXR-dependent signaling in the differentiation process.
Towards Multi-modal Finger Presentation Attack Detection (2018)

The wide deployment of biometric verification systems has also unveiled security and privacy issues. Among other vulnerabilities, presentation attacks directed to the capture device pose a severe security threat. That is, a gummy finger (known as presentation attack instrument, PAI) can be used to impersonate another subject and thereby gain illegal access to the system. To prevent such attacks, presentation attack detection (PAD) techniques have been proposed in the last decade. For the particular case of fingerprints, most approaches are based on conventional optical or capacitive sensors, acquiring a single image, and which can thus detect only a limited number of PAIs. In this work, we present a new multi-modal PAD approach based on a recently developed capture device, which is able to acquire four different types of samples: i) finger photos, ii) finger vein samples, iii) multi-spectral short wave infrared images, and iv) laser speckle contrast image sequence samples. Different ad-hoc algorithms have been developed for each set of images. The experimental evaluation over 35 PAIs, part of them used only at the test stage, shows the efficiency of the proposed approach in a realistic scenario, with an APCER of 6.6% for a BPCER of 0.2%.
Understanding subsalt illumination through ray-trace modeling, Part 2: Dipping salt bodies, salt peaks, and nonreciprocity of subsalt amplitude response (2001)

The interest in subsalt imaging has been fueled by numerous discoveries beneath salt in the Gulf of Mexico in the last decade. A most effective tool in making these discoveries is 3-D prestack depth migration (PreSDM), which allows imaging of reflectors under the salt sheets and of detached bodies of irregular shape. Ray-trace modeling can simulate seismic illumination problems such as shadow zones or seismic focusing and allow better interpretation of subsalt seismic data.
Cisplatin vestibular ototoxicity: Preliminary report. (1982)

Abstract Sixteen patients were monitored for vestibular ototoxicity while receiving cisplatin in dosages of 180 mg/M 2 . The incidence of preexisting vestibular functional abnormalities (31%) was higher than the incidence of ototoxicity (18%). Although the number of patients was not large enough for meaningful statistical comparison, the incidence of vestibular ototoxicity from cisplatin was low for the dosage levels employed. Based upon the results of this study, the following recommendations are made for monitoring cisplatin vestibular ototoxicity. 1 . All patients should receive vestibular tests prior to cisplatin administration. 2 . Subjects, who have reduced (or asymmetric) vestibular function upon pretherapy testing, should be monitored at least weekly for any change in function while receiving cisplatin. 3 . Subjects who are normal prior to therapy need to be tested only when cumulative doses exceed 400 mg. The severe nausea and vomiting associated with cisplatin chemotherapy is not related to vestibular ototoxicity.
A P2P intrusion detection system based on mobile agents (2004)

Traditional intrusion detection systems have a central coordinator with a static hierarchical architecture. We propose a peer-to-peer intrusion detection system that has no central coordinator. Our approach is like that of a "neighborhood watch". A virtual neighborhood is created where neighbors take on the task of looking out for each other. When an intrusion occurs they observe this intrusion and inform the residents about this intrusion and collectively take action. We use cooperating, mobile agents for intrusion detection. Each site periodically sends mobile agents to visit and check up on its neighbors and report back. When inconsistent or anomalous behavior is observed, the observer-neighbor initiates a voting process to take action against the compromised site.
Cutting off ciliary protein import: intraflagellar transport after dendritic femtosecond-laser ablation (2020)

Primary cilia, organelles protruding from the surface of eukaryotic cells, act as cellular antennae to detect and transmit signals from the extracellular environment. They are built and maintained by continuous cycles of intraflagellar transport (IFT), where ciliary proteins are transported between the ciliary base and tip. These proteins originate from the cell body because cilia lack protein synthesis machinery. How input from the cell body affects IFT and ciliary function is not well understood. Here, we use femtosecond-laser ablation to perturb the dendritic input of proteins to chemosensory cilia in living <i>Caenorhabditis elegans</i>. Using fluorescence microscopy, we visualize and quantify the real-time response of ciliary proteins to dendritic ablation<i>.</i> We find that the response occurs in three distinct stages. First, IFT dynein is activated within seconds, redistributing IFT components toward the ciliary base; second, the ciliary axoneme shortens and motors slow down; and third, motors leave the cilium. Depletion of ATP by adding azide also results in IFT slowdown and IFT components leaving the cilium, but not in activation of retrograde IFT. These results indicate that laser ablation triggers a specific mechanism important for IFT regulation that allows the cilium to rapidly adapt to changes in the outside environment.