gebhart/patrepeval huggingface dataset:
Quercetin/Hydroxypropyl-β-Cyclodextrin Inclusion Complex-Loaded Hydrogels for Accelerated Wound Healing (2022)

This study concentrated on developing quercetin/cyclodextrin inclusion complex-loaded polyvinyl alcohol (PVA) hydrogel for enhanced stability and solubility. Quercetin was encapsulated in hydroxypropyl-β-cyclodextrin (HP-β-CD) by the solvent evaporation method. The prepared quercetin/HP-β-CD inclusion complex showed 90.50 ± 1.84% encapsulation efficiency (%EE) and 4.67 ± 0.13% loading capacity (%LC), and its successful encapsulation was confirmed by FT-IR and XRD. The quercetin/HP-β-CD inclusion complex was well dispersed in viscous solutions of PVA in various amounts (0.5, 1.0, 1.5. 2.5, and 5.0% <i>w/v</i> ratio), and the drug-loaded polymer solution was physically crosslinked by multiple freeze-thaw cycles to form the hydrogel. The cumulative amount of quercetin released from the prepared hydrogels increased with increasing concentrations of the inclusion complex. The introduction of the inclusion complex into the PVA hydrogels had no influence on their swelling ratio, but gelation and compressive strength reduced with increasing inclusion complex concentration. The potential cytotoxicity of quercetin/HP-β-CD inclusion complex hydrogels was evaluated by MTT assay and expressed as % cell viability. The results show biocompatibility toward NCTC 929 clone cells. The inhibitory efficacy was evaluated with 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay, and the results show a higher level of antioxidant activity for quercetin/HP-β-CD inclusion complex hydrogels compared with free quercetin. The findings of our study indicate that the developed quercetin/HP-β-CD inclusion complex hydrogels possess the required properties and can be proposed as a quercetin delivery system for wound-healing applications.
Molecular characterization and potential sources of Citrus tristeza virus in Oman (2011)

A study was conducted to characterize occurrence, molecular variability and potential sources of Citrus tristeza virus (CTV) in Oman. A survey during 2009 and 2010 showed that CTV occurs in most (91%) of the surveyed districts. Moderate to high levels of infection with CTV in lime were detected in northern Oman (15–63%) compared to the south (0–12%). This could be related to the continuous introduction of infected citrus germplasm in the north from abroad, where CTV was detected in 45% of citrus seedlings imported from Syria, Lebanon, India, Pakistan and Egypt. CTV was detected for the first time in sweet lime, sweet lemon, citron, mandarin, sweet orange and sour orange and was found to be associated with stem pitting, stunting, leaf curling and vein clearing symptoms in many of the infected trees and seedlings in Oman. Bi‐directional reverse transcription‐PCR analysis of the coat protein (CP) gene of 22 randomly selected CTV‐positive samples provided evidence that severe strains of CTV exist in Oman. Cloning and sequencing the CP gene of six isolates showed that they have 91–100% nucleotide identity with each other and 96–99% with representative isolates from other parts of the world. Phylogenetic analysis of the CTV isolates showed that four belong to CTV Group 4. However, two isolates formed a separate clade with 100% bootstrap support for separation from Group 5. Phylogenetic analysis and coefficient of differentiation values suggest that the two isolates from Oman constitute a new CTV phylogenetic group.
620. Ready formation of ketals by 4-piperidones (1957)

P. Brookes and J. Walker, J. Chem. Soc., 1957, 3173 DOI: 10.1039/JR9570003173
Ribonucleases (2001)

Abstract Ribonucleases are a very heterogeneous group of enzymes, both with respect to structure and function. They all catalyse the cleavage of phosphodiester bonds, endonucleolytically or exonucleolytically, with more or less specificity. They occur ubiquitously and are involved, directly or indirectly, in almost every cellular process.
Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta (2003)

In this study we describe the ability of two human urotensin-II (hU-II) derivatives [Pen5,Orn8]hU-II(4-11) and [Pen5,DTrp7,Orn8]hU-II(4-11) (urantide) to block hU-II-induced contractions in the rat isolated thoracic aorta. Both compounds competitively antagonized hU-II- induced effects with pKB=7.4+/-0.06 (n=12) and pKB=8.3+/-0.09 (n=12), respectively. In contrast, neither [Pen5,Orn8]hU-II(4-11) nor urantide (1 microm each) was able to modify noradrenaline- or endothelin 1-induced contractile effects. At micromolar concentrations, [Pen5,Orn8]hU-II(4-11) produced weak (< or =25% of hU-II maximum) agonist responses in the rat aorta, whereas urantide was totally uneffective as agonist up to 1 microm. In addition, [Pen5,Orn8]hU-II(4-11) and urantide displaced [125I]urotensin II from specific binding at hU-II recombinant receptors (UT receptors) transfected into CHO/K1 cells (pKi=7.7+/-0.05, n=4 and pKi=8.3+/-0.04, n=4, respectively). To our knowledge, urantide is the most potent UT receptor antagonist so far described, and might represent a useful tool for exploring the (patho)physiological role of hU-II in the mammalian cardiovascular system.
Sterilization of Liquid and Semi-Solid Pharmaceutical Forms Using High Pressure Technology (2002)

The aim of this study was to investigate the use of HHP (High Hydrostatic Pressure) technology as a possible alternative method for decontamination and sterilization of sensitive drugs. We demonstrated the safety of HHP treatment on several sensitive biomolecules. A 10 min. HHP treatment inactivates totally pure suspensions of P. aeruginosa , C. albicans and spores of A. niger , but S. aureus needs a longer HHP duration treatment to be totally inactivated. Endospores appear to be more baroresistant.
Realtime human motion control with a small number of inertial sensors (2011)

This paper introduces an approach to performance animation that employs a small number of motion sensors to create an easy-to-use system for an interactive control of a full-body human character. Our key idea is to construct a series of online local dynamic models from a prerecorded motion database and utilize them to construct full-body human motion in a maximum a posteriori framework (MAP). We have demonstrated the effectiveness of our system by controlling a variety of human actions, such as boxing, golf swinging, and table tennis, in real time. Given an appropriate motion capture database, the results are comparable in quality to those obtained from a commercial motion capture system with a full set of motion sensors (e.g., XSens [2009]); however, our performance animation system is far less intrusive and expensive because it requires a small of motion sensors for full body control. We have also evaluated the performance of our system by leave-one-out-experiments and by comparing with two baseline algorithms.
Prevention of Acute Kidney Injury by Erythropoietin in Patients Undergoing Coronary Artery Bypass Grafting: A Pilot Study (2009)

In our small, pilot trial, prophylactic administration of EPO prevents AKI and improves postoperative renal function. These data are preliminary and require confirmation in a larger clinical trial.
From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics (2009)

These studies show the power of in-silico genetic mapping, and reveal a novel target for treating an important component of opioid addiction.
Comparison of the effectiveness of antibody and cell-mediated immunity against inhaled and instilled influenza virus challenge (2013)

These results demonstrate differences in protection that are dependent on challenge method, and suggest that cell-mediated immunity may be more accurately demonstrated in mouse inhalation studies. Furthermore, the data suggest immune mechanisms generally characterized as incomplete or weak in mouse models using liquid intranasal challenge may offer greater immunity against influenza infection than previously thought.
Controlled Ecological Life Support Systems: CELSS '89 Workshop (1986)

Topics discussed at NASA's Controlled Ecological Life Support Systems (CELSS) workshop concerned the production of edible biomass. Specific areas of interest ranged from the efficiency of plant growth, to the conversion of inedible plant material to edible food, to the use of plant culture techniques. Models of plant growth and whole CELSS systems are included. The use of algae to supplement and improve dietary requirements is addressed. Flight experimentation is covered in topics ranging from a Salad Machine for use on the Space Station Freedom to conceptual designs for a lunar base CELSS.
Wavelets, Ridgelets, and Curvelets for Poisson Noise Removal (2008)

In order to denoise Poisson count data, we introduce a variance stabilizing transform (VST) applied on a filtered discrete Poisson process, yielding a near Gaussian process with asymptotic constant variance. This new transform, which can be deemed as an extension of the Anscombe transform to filtered data, is simple, fast, and efficient in (very) low-count situations. We combine this VST with the filter banks of wavelets, ridgelets and curvelets, leading to multiscale VSTs (MS-VSTs) and nonlinear decomposition schemes. By doing so, the noise-contaminated coefficients of these MS-VST-modified transforms are asymptotically normally distributed with known variances. A classical hypothesis-testing framework is adopted to detect the significant coefficients, and a sparsity-driven iterative scheme reconstructs properly the final estimate. A range of examples show the power of this MS-VST approach for recovering important structures of various morphologies in (very) low-count images. These results also demonstrate that the MS-VST approach is competitive relative to many existing denoising methods.
Heavy Truck Safety - The Need To Know (1981)

&lt;div class="htmlview paragraph"&gt;This paper provides an overview of the current state of knowledge on medium and heavy truck safety and reviews the results of truck safety research sponsored by the Motor Vehicle Manufacturers Association.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;A number of issues have been raised about the accident experience of trucks, and the injuries and fatalities sustained by occupants. The diverse viewpoints and perceptions which exist on the reasons for these accidents and what countermeasures should be taken are reviewed.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The evolutionary nature of truck accident research is presented, pointing out that sufficient detailed accident and injury data are lacking. Corresponding information on truck configuration, size, weight and exposure data remain inadequate. The role of the vehicle, driver, and highway environment in accident causation must be known and methods to achieve this goal are examined.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Despite these limitations, there is progress in understanding the causes of truck accidents. MVMA-sponsored studies, including those which led to identification of “conspicuity” as an accident avoidance measure, are reviewed. Finally, recommendations for a comprehensive heavy truck accident causation study are presented.&lt;/div&gt;
Diagnostic Challenges and Solutions in Systemic Amyloidosis (2023)

Amyloidosis refers to a clinically heterogeneous group of disorders characterized by the extracellular deposition of amyloid proteins in various tissues of the body. To date, 42 different amyloid proteins that originate from normal precursor proteins and are associated with distinct clinical forms of amyloidosis have been described. Identification of the amyloid type is essential in clinical practice, since prognosis and treatment regimens both vary according to the particular amyloid disease. However, typing of amyloid protein is often challenging, especially in the two most common forms of amyloidosis, i.e., the immunoglobulin light chain amyloidosis and transthyretin amyloidosis. Diagnostic methodology is based on tissue examinations as well as on noninvasive techniques including serological and imaging studies. Tissue examinations vary depending on the tissue preparation mode, i.e., whether it is fresh-frozen or fixed, and they can be carried out by ample methodologies including immunohistochemistry, immunofluorescence, immunoelectron microscopy, Western blotting, and proteomic analysis. In this review, we summarize current methodological approaches used for the diagnosis of amyloidosis and discusses their utility, advantages, and limitations. Special attention is paid to the simplicity of the procedures and their availability in clinical diagnostic laboratories. Finally, we describe new methods recently developed by our team to overcome limitations existing in the standard assays used in common practice.
Differential plant response to toxins and elicitor proteins released by the potato and tomato pathogens Alternaria solani and Alternaria alternata (2022)

Abstract Early blight of potato and tomato, caused principally by Alternaria solani , results in extensive damage to foliar tissues. Symptoms are seen as expanding necrotic lesions. Lesions are sometimes surrounded by a halo of chlorotic tissue, however the basis for presence or absence of the distinctive halo have not been determined. To dissect the basis for lesion development a series of Alternaria-associated toxins and potential elicitor proteins were tested in potato and tobacco. Infiltration of leaves demonstrated that, while most of the pure toxins did not have a visible effect, two anthraquinones, bostrycin and altersolanon A, elicited a strong necrosis-mediated response. Extracts of solid and liquid cultures of A. solani yielded anthraquinones that also elicited a necrotic response. Two potential elicitor proteins were identified and cloned from the potato brown spot and early blight pathogens Alternaria alternata and A. solani, respectively. Agrobacterium-mediated infiltration and expression of the A. alternata xyloglucanase cel12-A and A. solani Hrip1 revealed that cel12-A had no apparent effect, whereas Hrip1 induced expanding tissue death and development of chlorotic halos. Development of chlorotic halos was dependent on leaf age, with older leaves exhibiting halos. It is proposed that specific toxin and elicitor production, in conjunction with tissue susceptibility mediate the outcomes of early blight symptoms.
Analysis of aromatic DNA adducts and 7,8-dihydro-8-oxo- 2′-deoxyguanosine in lymphocyte DNA from a case–control study of lung cancer involving minority populations (2000)

The purpose of this study was to examine the level of smoking-related aromatic DNA adducts and oxidative DNA damage in current smokers from a lung cancer case-control study in African Americans and Mexican Americans. In addition, mutagen sensitivity (bleomycin-induced chromatid breaks), a marker of genetic susceptibility, was assessed in these patients and correlated with the level of DNA damage. Lymphocyte DNA from cases and age-, sex-, and ethnicity-matched controls was analyzed for aromatic DNA adducts (43 cases and 47 controls) and the level of 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dG) was determined in 46 cases and 48 controls using 32P-postlabeling. Overall, lung cancer cases had significantly (P < 0.05) higher levels of aromatic DNA adducts and 8-oxo-dG (mean±SEM; 6.03±1.16/108 nucleotides and 5.82±0.77/105 nucleotides, respectively) compared to the controls (2.80±0.36/108 nucleotides and 3.65±0.56/105 nucleotides, respectively). The case-control differences for these two biomarkers were especially evident in current smokers. Both male and female lung cancer cases had higher levels of aromatic DNA adducts compared to the corresponding controls but only in men was the difference statistically significant (P=0.002). Cases who started smoking at earliest age had highest levels of aromatic DNA adducts and 8-oxo-dG. The level of aromatic DNA adducts in lung cancer cases, but not controls, was positively correlated with bleomycin-induced chromatid breaks (P=0.011). In contrast, the level of 8-oxo-dG was not correlated with mutagen sensitivity in either cases or controls or with the level of aromatic DNA adducts. The data suggest that levels of both aromatic DNA adducts and 8-oxo-dG may be useful in predicting risk of lung cancer in these minority populations. The correlation between aromatic DNA adducts and mutagen sensitivity in lung cancer cases and the trend for higher levels of DNA damage in cancer cases who started smoking earliest are particularly interesting and merit further study. Mol. Carcinog. 27:34–46, 2000. © 2000 Wiley-Liss, Inc.
Al2O3 Coatings Deposited By ALD on Al Alloys (2015)

The key question that was addressed in this work is the following: would a uniform surface layer of aluminium oxide on aluminium alloys be protective against corrosion despite the presence of intermetallic Al-Cu particles? To answer this question, well defined aluminium oxide coatings were deposited by atomic layer deposition (ALD) on the surface of a model binary aluminium-copper alloy (Al-Cu5%wt.) in which copper-rich particles were produced by ageing. The corrosion resistance of uncoated, mechanically polished aluminium alloy samples covered by a native oxide layer was compared with the one of aluminium alloy samples protected by a 20 nm thick Al 2 O 3 layer deposited by Atomic Layer Deposition (ALD). Detailed surface analysis was performed by X-ray Photoelectron Spectroscopy (XPS), Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and Scanning Electron Microscopy (SEM) on the samples before and after immersion in 0.01M NaCl + 0.3 % vol. H 2 O 2 (pH=6.2). The polished Al-Cu alloy with a thin native oxide layer (around 5 nm, as measured by XPS), exhibits a copper enrichment at the oxide/Al alloy interface, clearly evidenced by ToF-SIMS depth profiling. The ToF-SIMS chemical images and EDX analysis confirmed the presence of copper-rich intermetallics (Al 2 Cu) in the interfacial oxide/substrate region. A short immersion (~7 min) of this alloy in a near neutral NaCl solution lead to severe surface modifications: formation of mixed aluminium-copper oxide layer rich in CuO and Cu(OH) 2 (as shown by XPS), and formation of an inhomogeneous, thick aluminium oxide deposit (as shown by SEM and ToF-SIMS imaging). Localized corrosion in the vicinity of the intermetallic particles (well known as trenching around particles) is clearlyobserved by SEM and ToF-SIMS imaging. A significant improvement on corrosion resistance was observed after deposition of the 20 nm-thick Al 2 O 3 ALD coating. Despite the presence of intermetallics at the oxide/substrate interface (observed in the SEM) no significant corrosion occurred in the chloride solution, the Al 2 Cu particles remained intact, and no trenching around them was observed. In conclusion, the formation of a good quality alumina layer on the Al-5%Cu alloy is beneficial for its corrosion resistance. The coating can be deposited by ALD without prior removal of the intermetallic particles.
Energy Scavenging and Nontraditional Power Sources for Wireless Sensor Networks (2005)

Wireless sensor networks are poised to become a very significant enabling technology in many sectors. While there has been a significant research effort in this area for a number of years, only more recently have companies begun to offer standard wireless sensor platforms and customized wireless sensor network solutions. Almost all of the available platforms are designed to run on batteries that have a very limited lifetime. However, longer lifetimes are necessary if wireless sensor networks are to become a ubiquitous part of our environment. While progress can be made by reducing the power consumption, eventually alternative power sources will need to be employed. This chapter reviews many potential power sources for wireless sensor nodes. Traditional power sources, such as batteries, are reviewed along with emerging technologies and currently untapped sources. Potential power sources are classified as energy reservoirs, power distribution methods, or power scavenging methods, which enable wireless nodes to be completely self-sustaining. Several power sources capable of providing power on the order of 100 µW/cm3 for very long lifetimes are feasible. It is the authors' opinion that no single power source will suffice for all applications, and that the choice of a power source needs to be considered on an application-by-application basis.
Bidirectional reflection functions from surface bump maps (1987)

The Torrance-Sparrow model for calculating bidirectional reflection functions contains a geometrical attenuation factor to account for shadowing and occlusions in a hypothetical distribution of grooves on a rough surface. Using an efficient table-based method for determining the shadows and occlusions, we calculate the geometric attenuation factor for surfaces defined by a specific table of bump heights.Diffuse and glossy specular reflection of the environment can be handled in a unified manner by using an integral of the bidirectional reflection function times the environmental illumination, over the hemisphere of solid angle above a surface. We present a method of estimating the integral, by expanding the bidirectional reflection coefficient in spherical harmonics, and show how the coefficients in this expansion can be determined efficiently by reorganizing our geometric attenuation calculation.
Linking capacity loss and retention of nickel hexacyanoferrate to a two-site intercalation mechanism for aqueous Mg2+ and Ca2+ ions (2019)

Prussian blue analogues (PBAs) are promising cation intercalation materials for electrochemical desalination and energy storage applications. Here, we investigate the mechanism of capacity fade and degradation of nickel hexacyanoferrate (NiHCFe) during galvanostatic cycling in aqueous electrolytes that are rich in either Mg2+ or Ca2+. We combine experimental characterization, first principles electronic structure calculations, statistical mechanics and lattice-percolation modeling of electron transfer to elucidate the mechanisms responsible for the degradation of NiHCFe and its partial retention of capacity. Electrochemical characterization of porous NiHCFe electrodes suggests a two-site intercalation mechanism, while spectroscopy reveals the presence of Ni2+ and Fe(CN)63- ions in the electrolyte post cycling in Mg2+(aq). Using simple coprecipitation reactions, we show that Mg2+ and Ni2+ can coexist in the lattice framework, forming stable PBAs. Galvanostatic cycling of these PBAs shows that the presence of Mg2+ in the lattice framework results in the dissolution of Mg1.5FeIII(CN)6 in water during oxidation. We propose that Mg2+ can partially substitute Ni2+ ions in the lattice framework during galvanostatic cycling, displacing the substituted Ni2+ ions into interstitial sites. Based on differential capacitance analysis we show that Mg2+ intercalates into interstitial sites at ∼0.45 V vs. Ag/AgCl and it displaces Ni2+ in the lattice framework at ∼0.05 V vs. Ag/AgCl. Substitution of Ni2+ leads to Fe(CN)63- and Ni2+ ions being removed into the electrolyte during oxidation. Using first principles density functional theory (DFT) calculations combined with a statistical mechanics model, we verify the thermodynamic feasibility of the proposed reaction mechanism and predict the fraction of Ni2+ ions being substituted by Mg2+ during intercalation. Further, analysis of the electron density distribution and local density of states indicates that Mg2+ ions can act as insulating defects in the lattice framework that render certain Fe ions electrically inactive and likely contribute to capacity fade along with dissolution of Fe(CN)63-.