gebhart/patrepeval huggingface dataset:
The method of rational dispatching a sequence of heterogeneous repair works (2018)

For critically important power systems, some repair works should be performed by one repair brigade at the same time. Conditions for performing different works are often characterized by uncertainties. In practice, the term is given for each work, and possible damages exist if the performance of works is not well-timed. Taking into account these factors, the sequence of performing heterogeneous repair works essentially influences the safety and/or efficiency of the power system. The method of rational dispatching of the sequence of heterogeneous repair works considering the requirements of timeliness for their performance is proposed in this paper. The rational sequence of works is established by criteria of minimizing integral damages based on the best choices from different dispatcher technologies and their parameters (such as distribution of work call types by priorities, distribution of call priorities into groups, appointment of technologies inside groups). A possible effect is demonstrated by an example.
Influence of Shape of Cross Section on Properties of GF Reinforced Thermo-Plastics (2010)

Glass-fiber (GF) is good reinforcement because of its large aspect-ratio. GF reinforced thermoplastics (GFRTP) have high mechanical properties, but shortages as that a warp easily occur because of different shrinkage of MD (mold flow direction) and TD (tangential direction of flow). In this study, the effect of new GF having some flat shape of cross section on properties of GFRTP was examined. The modified GF indicated good shrinkage ratio of TD to MD, and restrained the warp of GFRTP. In normal GF, flexural strength and IZOD impact strength of TD went down compared with MD. But for the flat GF, the high reinforcement in TD was indicated same as in MD. Besides the modified GF accompanied with melt polymer at lower share rate in comparison with normal GF and so it indicated good fluidity in mold. The result suggests that the importance of control of fiber shape is same as that of length.
HIV/AIDS and childbirth: a feminist midwife's view. (1992)

This paper explores the impact that the presence of the Human Immunodeficiency Virus has had on the care of pregnant and childbearing women in Victoria and on my professional life as a midwife in private practice and a midwife educator. It provides an overview of my personal experience and discusses how the issues associated with HIV/AIDS have gradually infiltrated the area of midwifery care in our hospital system. The prejudices and practices of the dominant patriarchal medical system have resulted in women being oppressed and controlled in pregnancy and labour in institutions that are supposed to be there to serve their needs.
Relative Reactivities of Organometallic Compounds. XXVII. Triphenylthallium (1939)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRelative Reactivities of Organometallic Compounds. XXVII. TriphenylthalliumHenry. Gilman and R. G. JonesCite this: J. Am. Chem. Soc. 1939, 61, 6, 1513–1515Publication Date (Print):June 1, 1939Publication History Published online1 May 2002Published inissue 1 June 1939https://pubs.acs.org/doi/10.1021/ja01875a051https://doi.org/10.1021/ja01875a051research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dystrophic epidermolysis bullosa pruriginosa: a new case series of a rare phenotype unveils skewed Th2 immunity (2021)

Our study confirms the stereotyped presentation of DEB-Pr with large intra-familial variability in disease expression. Mast cell infiltration, elevated IgE and increased Th2 subset without atopy strongly support a role of Th2-mediated immunity in DEB-Pr, and further argue for new targeted therapeutic options such as dupilumab.
Abstract 2230: Interaction of SJG-136 with cognate sequences of oncogenic transcription factors. (2013)

Abstract The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are sequence-selective DNA minor-groove interacting agents. They have a chiral centre at their C11a(S)-position which provides them with the appropriate 3-dimensional shape to fit securely within the DNA minor-groove. They also possess a “soft” electrophilic imine moiety at their N10-C11 position which can form an aminal linkage with the C2-NH2 group of a guanine base. The PBD dimer SJG-136 is presently in Phase II clinical trials in ovarian cancer and leukaemia. Transcription factors act through direct or indirect binding to specific DNA consensus sequences within gene regulatory regions, or by forming a complex with other proteins which then act as transcription factors. Covalent or non-covalent interaction of small molecules with key consensus DNA bases can prevent a transcription factor from recognizing its cognate sequence, thus preventing expression of genes critical for the survival and proliferation of cancer cells. The cognate sequences of a number of oncogenic transcription factors are unusually rich in GC sequences and provide ideal alkylation substrates (for both inter- and intrastrand cross-links and mono-alkylation) for both PBD dimers (e.g. SJG-136) and PBD monomers, and there is growing evidence that PBDs exert their pharmacological effects through this mechanism. We have developed a reversed-phase ion pair HPLC/MS method as a tool to evaluate the interaction of DNA-binding molecules with oligonucleotides of varying length and sequences. Using this methodology along with custom-designed oligonucleotides containing the cognate sequences of the transcription factors NFκB, AP-1, EGR-1 and Stat3, all of which contain ideal GC-rich binding sequences for SJG-136, we have observed both kinetic and thermodynamic adduct formation with SJG-136. Crucially, we observed a significant difference in rate and extent of adduct formation between the different cognate sequences which could partly explain the differences in activity of SJG-136 toward different tumour cell lines. For example, SJG-136 formed an adduct rapidly with the NFκB sequence (&amp;gt;50% adduct within 3 hours), moderately with the STAT3 (&amp;gt;35% adduct within 3 hours) and EGR-1 cognate sequences (&amp;gt;30% adduct within 3 hours) while showing insignificant adduct formation with the AP-1 cognate sequence (&amp;lt; 5% adduct within 3 hours) even though their GC contents are comparable. These findings add to knowledge of the possible mechanism of SJG-136, and could help with interpretation of the activity of SJG-136 in various biochemical and pharmacological assays. Citation Format: Julia Mantaj, David E. Thurston, Khondaker M. Rahman. Interaction of SJG-136 with cognate sequences of oncogenic transcription factors. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2230. doi:10.1158/1538-7445.AM2013-2230
Variable Immunodominance Hierarchies for H2-M3-Restricted N -Formyl Peptides Following Bacterial Infection (2001)

H2-M3-restricted presentation of N-formyl methionine (f-Met) peptides to CD8(+) T cells provides a mechanism for selective recognition of bacterial infection. In this report we demonstrate that Listeria monocytogenes infection induces distinct CD8(+) T cell populations specific for each of the known Listeria-derived formyl methionine peptides presented by M3. The sum H2-M3-restricted, Listeria-specific T cell response constitutes a major fraction of the total CD8(+) T cell response to primary infection. H2-M3-restricted T cell populations expand synchronously in vivo and achieve peak frequencies approximately 2 days earlier than MHC class Ia-restricted T cell populations. Although cross-recognition of different f-Met peptides by M3-restricted T cells was previously described, costaining of CD8(+) T cells ex vivo with H2-M3 tetramers complexed with different f-Met peptides shows that the majority of Listeria-specific, M3-restricted CD8(+) T cells are peptide specific. In contrast to the highly predictable size and immunodominance hierarchies of MHC class Ia-restricted T cell responses, the magnitudes of T cell responses specific for H2-M3-restricted peptides are remarkably variable between genetically identical mice. Our findings demonstrate that H2-M3-restricted T cell responses are distinct from classically restricted T cell responses to bacterial infection.
A nuclear magnetic resonance study of the self-association of adriamycin and daunomycin in aqueous solution (1985)

A study of the self-association of the anthracycline antibiotics adriamycin and daunomycin was undertaken in D 2 O and methanol using nmr at 400 MHz. From the concentration dependence of the 2 H linewidths obtained on selectively deuterated daunomycin it was determined that daunomycin forms a dimer in aqueous solution. The concentration dependence of the chemical shift of the 4 methoxy group of adriamycin was fit to a dimer model in which only the non-protonated neutral species of adriamycin participated in the self-association process. The data were in agreement with the dimer model if a pK of 7.4 was used. The pH dependence of the self-association was fit to two ionizations, one with a pK of 8.2 and the other with a pK of 8.8. The latter pK was attributed to the ionization of the phenol based on the work of Eksborg. It was concluded that only the deprotonated amine of adriamycin took part in the dimerization process. The dimerization of adriamycin is characterized by a ΔS of approximately 3 cal deg −1 M −1 and a ΔH of −3.45 kcal M −1 . At room temperature the association constant for the dimerization process was found to be 4.0 × 10 5 M −1 . These results were discussed in terms of earlier studies by Barthelemy-Clavey etal., Martin, and Chaires etal.
[Evolution and Development Trend of Lung Cancer Surgical Incision]. (2016)

Minimally invasive, safe and tumor-free are the main principles of the choice of surgical incision in lung cancer surgery. In recent years, with the advances in minimally invasive techniques, single-port video assisted thoracic surgery (VATS), robot-assisted thoracoscopic (RATS), suboxiphoid single-port VATS, simultaneous bilateral VATS pulmonary resection, are emerging approaches, single-port VATS has become one of the most exciting new developments in minimally invasive thoracic surgery in recent years. This paper reviews the evolution and trends of surgical incision in lung cancer surgery.
Let's share CommRad: Effect of radar interference on an uncoded data communication system (2016)

Spectrum sharing between radar and communications systems is currently under investigation because of the high demand for new wireless services and shortage of available bandwidth. To effectively design their coexistence, it is crucial to understand how current unaltered radar and communication systems would affect one another. This paper investigates the effect of radar interference on an uncoded data communication system where the optimal Maximum-A-Posteriori decoder is used and where the bandwidth of the radar system is much larger than the one of the communication system. Conclusions depend on how the radar interference power, measured by the Interference-to-Noise ratio (INR), compares with the intended signal power, measured by the Signal-to-Noise ratio (SNR). For the case of real-valued modulation schemes, three regimes emerge: (a) Treat interference as Gaussian noise: when INR<;SNR it is optimal to use the threshold decoder for Gaussian noise only. The probability of error increases with INR. (b) Interference cancellation: when INR>>SNR the optimal receiver estimates the radar interference and subtracts it from the received signal; in the process of canceling interference, part of the useful signal is also cancelled, which reduces the effective SNR at the receiver. The probability of error exhibits an irreducible error floor, which can be exactly characterized and behaves like a narrow-band fading channel with multiplicative fading that is perfectly known at the receiver. (c) When INR≈SNR, the probability of error attains its maximum value, thus indicating that there is a worst operating INR for any given SNR.
Cytoprotective Effects of a Novel Nrf2 Activator, RS9, in Rhodopsin Pro347Leu Rabbits (2015)

Activation of Nrf2 signaling has potential as a novel approach for the prevention and treatment of RP, not only by driving intrinsic antioxidant enzymes, but also by inhibiting inflammatory responses. Although microspheres were employed in this study, small implants that release more compounds might be a realistic method for clinical trials.
A Proposed Framework for Calibration of Available Bandwidth Estimation Tools (2006)

Examining the validity or accuracy of proposed available bandwidth estimation tools remains a challenging problem. A common approach consists of evaluating a newly developed tool using a combination of simple nstype simulations and feasible experiments in situ (i.e., using parts of the actual Internet). In this paper, we argue that this strategy tends to fall short of establishing a reliable "ground truth," and we advocate an alternative in vitro-like methodology for calibrating available bandwidth estimation tools that has not been widely used in this context. Our approach relies on performing controlled laboratory experiments and using tools to visualize and analyze the relevant tool-specific traffic dynamics. We present a case study of how two canonical available bandwidth estimation tools, SPRUCE and PATHLOAD, respond to increasingly more complex cross traffic and network path conditions. We expose measurement bias and algorithmic omissions that lead to poor tool calibration. As a result of this evaluation, we designed a calibrated available bandwidth estimation tool called YAZ that builds on the insights of PATHLOAD. We show that in head to head comparisons with SPRUCE and PATHLOAD, YAZ is significantly and consistently more accurate with respect to ground truth, and reports results more quickly with a small number of probes.
Haters Gonna Hate? How Removing Downvote Option Impacts Discussion Culture in Online Forum. (2020)

This study examines the implications of a policy to remove the downvote option from an online discussion forum. Our analysis shows that after the downvote option is removed, both the number of posts and replies significantly increase. Interestingly, the average sentiment of the replies does not change significantly, which suggests that the removal of downvote option does not necessarily lead to users expressing negative impressions in their replies instead. We also find that the frequencies of product attribute related words significantly increase after the policy change. Finally, the average Gini coefficient of topics per post significantly decreases, suggesting that the topic distribution in replies became more diverse after the policy change. The latter two results together suggest that after the policy change users tend to post replies that are richer in information content. Our findings suggest that removing the downvote option may positively influence the discussion culture on the platform.
Occurrence of two somatostatin variants in the frog brain: characterization of the cDNAs, distribution of the mRNAs, and receptor-binding affinities of the peptides. (1996)

In tetrapods, only one gene encoding a somatostatin precursor has been identified so far. The present study reports the characterization of the cDNA clones that encode two distinct somatostatin precursors in the brain of the frog Rana ridibunda. The cDNAs were isolated by using degenerate oligonucleotides based on the sequence of the central region of somatostatin to screen a frog brain cDNA library. One of the cDNAs encodes a 115-amino acid protein (prepro-somatostatin-14; PSS1) that exhibits a high degree of structural similarity with the mammalian somatostatin precursor. The other cDNA encodes a 103-amino acid protein (prepro-[Pro2, Met13]somatostatin-14; PSS2) that contains the sequence of the somatostatin analog (peptide SS2) at its C terminus, but does not exhibit appreciable sequence similarity with PSS1 in the remaining region. In situ hybridization studies indicate differential expression of the PSS1 and PSS2 genes in the septum, the lateral part of the pallium, the amygdaloid complex, the posterior nuclei of the thalamus, the ventral hypothalamic nucleus, the torus semicircularis and the optic tectum. The somatostatin variant SS2 was significantly more potent (4-6 fold) than somatostatin itself in displacing [125I-Tyr0, D-Trp8] somatostatin-14 from its specific binding sites. The present study indicates that the two somatostatin variants could exert different functions in the frog brain and pituitary. These data also suggest that distinct genes encoding somatostatin variants may be expressed in the brain of other tetrapods.
Valley-orbit splittings for the donor states in GaP (1981)

We report on a calculation of the role of the "camel's-back" structure in determining valley-orbit splittings for the low-lying states in GaP:S. We find a splitting of about 49 meV between the lowest-lying state of ${\ensuremath{\Gamma}}_{1}({A}_{1})$ symmetry and that of ${\ensuremath{\Gamma}}_{3}(E)$ symmetry. The relative oscillator strength ratios for the two-electron transition luminescence lines are estimated. Both the line positions and oscillator strength ratios for these states are in reasonably good agreement with the experimental data.
Augmented reality system to assist inexperienced pool players (2016)

Pool and billiards are amongst a family of games played on a table with six pockets along the rails. This paper presents an augmented reality tool designed to assist unskilled or amateur players of such games. The system is based on a projector and a Kinect 2 sensor placed above the table, acquiring and processing the game on-the-fly. By using depth information and detecting the table’s rails (borders), the balls’ positions, the cue direction, and the strike of the ball, computations predict the resulting balls’ trajectories after the shot is played. These results—trajectories, visual effects, and menus—are visually output by the projector, making them visible on the snooker table. The system achieves a shot prediction accuracy of 98% when no bouncing occurs.
Abstract 5012: Characterizing the functional significance of PDGFRAK385I and PDGFRAK385L extracellular domain mutations in the newly defined myxoid glioneuronal tumor (2023)

Abstract In 2021, the World Health Organization (WHO) approved new diagnostic guidelines that stratify central nervous system (CNS) tumors based on molecular, transcriptomic, and epigenetic analysis instead of relying solely on phenotypic characterization and added twenty-two new CNS tumor entities based on these guidelines. Our focus is on one of these newly defined entities—myxoid glioneuronal tumors—a slow growing, mucinous glial tumor defined by a pathognomonic dinucleotide substitution in the extracellular domain of PDGFRA p.K385I/L. PDGFRA p.K385I/L remains a variant of unknown significance, however, constitutive activation of PDGFRA is well established as a pharmacologically actionable, oncogenic driver present in a variety of tumor types. Here we report the functional characterization of PDGFRAK385I and PDGFRAK385L by assessing transforming potential using Ba/F3 cells and immortalized human astrocytes. Our results demonstrate that both p.K385I and K385L substitutions are oncogenic, driving cytokine-independent Ba/F3 cell growth and anchorage-independent colony formation. Western blot analysis of downstream cellular signaling pathways in the absence of PDGF-ligand further confirm the activating nature of these mutations, showing robust phosphorylation of PDGFRA and constitutive phosphorylation of downstream signaling effectors ERK1/2, SHP2, and STAT3. To assess whether PDGFRAK385I and PDGFRAK385L are pharmacologically actionable, we tested multiple tyrosine kinase inhibitors with known activity against PDGFRA aberrant cancers using our mutant-transformed PDGFRA Ba/F3 cells. We found that the PDGFRAK385I and PDGFRAK385L mutants were sensitive to inhibitors axitinib, AZD-3229, and avapritinib at therapeutically relevant concentrations. Further, these mutants showed resistance to imatinib, nilotinib, and crenolanib underscoring the importance of pharmacogenomic investigation. No appreciable difference in sensitivity or resistance profiles was observed between the two mutants. In summary, our findings indicate that these previously uncharacterized p.K385I/L extracellular domain mutations in PDGFRA are oncogenic and represent a pharmacologically actionable target that could be harnessed to increase therapeutic options in the setting of myxoid glioneuronal tumors. Citation Format: Catherine Z. Beach, Romel Somwar, Matthew D. Wood, Monika A. Davare. Characterizing the functional significance of PDGFRAK385I and PDGFRAK385L extracellular domain mutations in the newly defined myxoid glioneuronal tumor. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5012.