gebhart/patrepeval huggingface dataset:
Integrating Manufacturing Execution and Business Management systems with soft computing (2010)

A Manufacturing Execution System (MES) is a highly complex, large, multi-task application that is used to manage production in companies and factories. It monitors and tracks every aspect of all factory-based manufacturing processes. One of the challenges of a MES is to find ways of integrating it with other information techology (IT) systems; i.e., business process management (BPM) systems, so that compatible information may be shared between both systems. This work studies the integration of a local company MES into a BMP to assist with budgeting, in which a data set is gathered from the MES and a soft computing model helps the expert with cost-level estimation. Various modelling methods are used, such as fuzzy rule based ones, in order to determine whether white box or black box models are suitable for the task. The results of the study show how information may be integrated between manufacturing and business management software.
Antiviral agents. 5H-as-Triazino[5,6-b]indoles (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntiviral agents. 5H-as-Triazino[5,6-b]indolesJan M. Z. Gladych, Roy Hornby, John H. Hunt, David Jack, John J. Boyle, Robert J. Ferlauto, Richard F. Haff, Charles G. Kormendy, Fredrick J. Stanfield, and Richard C. StewartCite this: J. Med. Chem. 1972, 15, 3, 277–281Publication Date (Print):March 1, 1972Publication History Published online1 May 2002Published inissue 1 March 1972https://doi.org/10.1021/jm00273a017RIGHTS & PERMISSIONSArticle Views249Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (444 KB) Get e-Alerts Get e-Alerts
Choice of Short-Term and Long-Term Debt in Five Eastern European Countries (2005)

This Article is brought to you for free and open access by Scholarly Commons at Hofstra Law. It has been accepted for inclusion in Journal of International Business and Law by an authorized administrator of Scholarly Commons at Hofstra Law. For more information, please contact
A novel T cell evasion mechanism in persistent RNA virus infection. (2014)

Hepatitis C virus (HCV) and GB virus type C (GBV-C) are associated with impaired T cell function despite the fact that HCV replicates in hepatocytes and GBV-C in a small proportion of lymphocytes. Recently, we showed that HCV and GBV-C E2-envelope proteins reduce T cell activation via the T cell receptor (TCR) by competing for phosphorylation with a critical kinase in the TCR signaling cascade (Lck). E2 interfered with TCR signaling in E2 expressing cells and in bystander cells. The bystander effect was mediated by virus particles and extracellular microvesicular particles (exosomes). Multiple kinase substrate sites are predicted to reside on viral structural proteins and based on bioinformatic predictions, many RNA virus pathogens may interfere with TCR signaling via a similar mechanism. Identification of T cell inhibitory effects of virus structural proteins may provide novel approaches to enhance the immunogenicity and memory of viral vaccines.
PDK1 inhibition is a novel therapeutic target in multiple myeloma (2012)

The present data suggest that the Warburg effect is operative in MM cells. As PDK1 is not overexpressed in normal tissues, PDK1 inhibition could serve as a novel therapeutic approach.
Characterization of sol-gel prepared WO3 thin films as a gas sensor (1999)

Tungsten trioxide (WO3) thin films have been prepared by the sol-gel process and annealed at different temperatures of 400, 500, 600, and 700 °C for 1 h. The morphology, microstructure, crystalline structure, and composition of the films have been analyzed using scanning electron microscopy (SEM), x-ray diffraction, Rutherford backscattering spectroscopy (RBS), and x-ray photoelectron spectroscopy (XPS) techniques. The SEM analysis showed that the films annealed at 400 °C are smooth and uniform. However, these evolved as granular at an annealing temperature of 500 °C. The films annealed at still higher temperatures have two distinct grains of different shapes and sizes. The films annealed below 400 °C are amorphous. Annealing at 500 °C resulted in the films having polycrystalline structure. RBS and XPS characterization have revealed that the films annealed at 400 °C are stoichiometric. Annealing above this temperature resulted in the films becoming off-stoichiometric. The electrical resistance of the films annealed at 500 °C increased 18 times when exposed to 175 ppb O3 gas compared to the air exposure, with the response time being as short as 1–2 min.
Performance Improvement of Nanocatalysts by Promoter-Induced Defects in the Support Material: Methanol Synthesis over Cu/ZnO:Al (2013)

Addition of small amounts of promoters to solid catalysts can cause pronounced improvement in the catalytic properties. For the complex catalysts employed in industrial processes, the fate and mode of operation of promoters is often not well understood, which hinders a more rational optimization of these important materials. Herein we show for the example of the industrial Cu/ZnO/Al2O3 catalyst for methanol synthesis how structure-performance relationships can deliver such insights and shed light on the role of the Al promoter in this system. We were able to discriminate a structural effect and an electronic promoting effect, identify the relevant Al species as a dopant in ZnO, and determine the optimal Al content of improved Cu/ZnO:Al catalysts. By analogy to Ga- and Cr-promoted samples, we conclude that there is a general effect of promoter-induced defects in ZnO on the metal-support interactions and propose the relevance of this promotion mechanism for other metal/oxide catalysts also.
Crosslinking of actin filaments is caused by caldesmon aggregates, but not by its dimers (1985)

A recent report by Bretscher [(1984) J. Biol. Chem. 259, 12873-12880] showed that caldesmon prepared by his method crosslinks actin filaments to form thick bundles. This is in contrast to the results of previous work that caldesmon binds to F-actin but does not cause any gelation [(1981) Proc. Natl. Acad. Sci. USA 78, 5652-5655]. The present work clearly showed that caldesmon purified according to Bretscher does not cause any gelation of F-actin. However, caldesmon aggregates formed by concentration or by freeze-thawing gelated F-actin to form bundles.
Table S2 from Investigation of Antigen-Specific T-Cell Receptor Clusters in Human Cancers (2023)

&lt;p&gt;Three common HLA alleles predicted by NetMHC with strong binding affinities to a HSFX1 derived 9-mer peptide (HSFX1: 384-392).&lt;/p&gt;
New trends in space x-ray optics (2017)

The X-ray optics is a key element of various X-ray telescopes, X-ray microscopes, as well as other X-ray imaging instruments. The grazing incidence X-ray lenses represent the important class of X-ray optics. Most of grazing incidence (reflective) X-ray imaging systems used in astronomy but also in other (laboratory) applications are based on the Wolter 1 (or modified) arrangement. But there are also other designs and configurations proposed, used and considered for future applications both in space and in laboratory. The Kirkpatrick-Baez (K-B) lenses as well as various types of Lobster-Eye optics and MCP/Micropore optics serve as an example. Analogously to Wolter lenses, the X-rays are mostly reflected twice in these systems to create focal images. Various future projects in X-ray astronomy and astrophysics will require large segments with multiple thin shells or foils. The large Kirkpatrick-Baez modules, as well as the large Lobster-Eye X-ray telescope modules in Schmidt arrangement may serve as examples. All these space projects will require high quality and light segmented shells (bent or flat foils) with high X-ray reflectivity and excellent mechanical stability. The Multi Foil Optics (MFO) approach represent a promising alternative for both LE and K-B X-ray optical modules. Several types of reflecting substrates may be considered for these applications, with emphasis on thin float glass sheets and, more recently, high quality silicon wafers. This confirms the importance of non- Wolter X-ray optics designs for the future. Future large space X-ray telescopes (such as IXO) require precise and light-weight X-ray optics based on numerous thin reflecting shells. Novel approaches and advanced technologies are to be exploited and developed. In this contribution, we refer on results of tested X-ray mirror shells produced by glass thermal forming (GTF) and by shaping Si wafers. Both glass foils and Si wafers are commercially available, have excellent surface microroughness of a few 0.1 nm, and low weight (the volume density is 2.5 g cm<sup>-3</sup> for glass and 2.3 g cm<sup>-3</sup> for Si). Technologies are needed to be exploited; how to shape these substrates to achieve the required precise Xray optics geometries without degradations of the fine surface microroughness. Although glass and recently silicon wafers are considered to represent most promising materials for future advanced large aperture space Xray telescopes, there also exist other alternative materials worth further study such as amorphous metals and glassy carbon [1]. In order to achieve sub-arsec angular resolutions, principles of active optics have to be adopted.
Data from A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms (2023)

&lt;div&gt;Abstract&lt;p&gt;Myeloproliferative neoplasms (MPN) are chronic blood diseases with significant morbidity and mortality. Although sequencing studies have elucidated the genetic mutations that drive these diseases, MPNs remain largely incurable with a significant proportion of patients progressing to rapidly fatal secondary acute myeloid leukemia (sAML). Therapeutic discovery has been hampered by the inability of genetically engineered mouse models to generate key human pathologies such as bone marrow fibrosis. To circumvent these limitations, here we present a humanized animal model of myelofibrosis (MF) patient-derived xenografts (PDX). These PDXs robustly engrafted patient cells that recapitulated the patient's genetic hierarchy and pathologies such as reticulin fibrosis and propagation of MPN-initiating stem cells. The model can select for engraftment of rare leukemic subclones to identify patients with MF at risk for sAML transformation and can be used as a platform for genetic target validation and therapeutic discovery. We present a novel but generalizable model to study human MPN biology.&lt;/p&gt;Significance:&lt;p&gt;Although the genetic events driving MPNs are well defined, therapeutic discovery has been hampered by the inability of murine models to replicate key patient pathologies. Here, we present a PDX system to model human myelofibrosis that reproduces human pathologies and is amenable to genetic and pharmacologic manipulation.&lt;/p&gt;&lt;p&gt;&lt;i&gt;This article is highlighted in the In This Issue feature, p. 2945&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
The centromeric part of the human natural killer (NK) receptor complex: lectin‐like receptor genes expressed in NK, dendritic and endothelial cells (2001)

The human natural killer (NK) receptor complex encompasses a region of about 2 Mb on the short arm of chromosome 12. It contains at least 18 lectin-like receptor genes, of which some are expressed in NK and NK/T cells and function as NK receptors. Close to the CD94 and NKG2 NK receptor genes in the centromeric part, a novel family of genes, expressed in myeloid, dendritic and/or endothelial cells, recently became evident. These genes encode a receptor for oxidized low density lipoprotein in endothelial cells and three other receptors potentially serving regulatory functions in dendritic cells. Although the overall structure of the human NK receptor complex is similar to the syntenic rodent regions, the centromeric part lacks the cluster of Ly49 genes. This supports the notion that recognition of MHC class Ia molecules has evolved separately in rodents and humans in the lectin-like Ly49 and the killer immunoglobulin-like receptors, respectively. In the telomeric part, other lectin-like genes expressed in different hematopoietic lineages are found. The receptors of the NK receptor complex apparently serve important functions in several leukocytes and in endothelial cells, and the exact role of these receptors, their ligands, and their distinct and co-ordinate regulation in different cell lineages warrants further investigation.
Stability of Synthetic Rubber Dispersions. II. Coagulation of Neoprene Latices by Freezing. (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStability of Synthetic Rubber Dispersions. II. Coagulation of Neoprene Latices by Freezing.H. W. WalkerCite this: J. Phys. Chem. 1947, 51, 2, 451–460Publication Date (Print):February 1, 1947Publication History Published online1 May 2002Published inissue 1 February 1947https://doi.org/10.1021/j150452a011RIGHTS & PERMISSIONSArticle Views116Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (525 KB) Get e-Alerts
Effect of vigabatrin (gamma-vinyl GABA) on amino acid levels in CSF of epileptic patients. (1988)

Vigabatrin (gamma-vinyl GABA) is a new anticonvulsive drug that irreversibly inhibits the activity of GABA transaminase. The effect of vigabatrin on neurotransmission-related amino acids in CSF of 28 epileptic patients was studied and the relationship between the amino acid pattern and clinical response during 7 months of administration of vigabatrin. Of this study population, 46% had more than 50% decrease in seizure frequency (responders). In 54% the seizures decreased less than 50% (nonresponders). In the whole study group, the levels of total GABA during vigabatrin treatment were 283%, free GABA 197%, homocarnosine 310% and glycine 128% that of the levels at baseline in the same patients. Glutamate, glutamine, aspartate, asparagine, and taurine concentrations did not change. The amino acid pattern in CSF during administration of vigabatrin did not differ significantly in responders and nonresponders. The study suggests that both GABAergic and glycinergic neurotransmission are affected by vigabatrin. The changes in CSF levels of neurotransmitter amino acids are, however, not necessarily related to the clinical response.
3D particle-in-cell simulations of small-diameter self-magnetic-pinch diodes (2012)

Flash x-radiography usually involves the creation of a pulse of intense bremsstrahlung whose duration is short compared to the motion of the object being radiographed. In many applications it is also desirable to have a very bright source that produces high-spatial-resolution images. For these applications a figure-of-merit (FOM) that provides a measure of the source brightness can be defined as, FOM = D/R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , where D is the dose in CaF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> at a distance of 1 m from the source and R (usually referred to as the radiographic spot size) is a number that characterizes the spatial extent of the radiation source. One method of creating a high FOM source uses a self-magnetic-pinch (SMP) electron-beam diode. [1] In relevant experiments on RITS-6 [2] and Mercury [3] inductive voltage adders IVA's, magnetically-insulated electron-flow in the adder can be a significant fraction of the current available to drive the SMP. It is believed that the magnetically-insulated flow produces an undesirably large radiographic spot if it is allowed to strike the x-ray target. Therefore, the approach adopted on RITS-6 and Mercury has been to dump this electron flow prior to the x-ray target. This usually involves the use of very large hardware and a loss of up to 50% of the available current. In this talk, we will present results from 3D LSP [4] particle-in-cell simulations of the coupling of magnetically-insulated electron-flow to an SMP diode. These simulations show that asymmetries in the electrical power-flow can cause the radiographic spot to wander. These simulations further show that nearly all the electrical current can be coupled to the SMP diode. However, in this situation the radiographic spot size is larger than cases without electron-flow in the SMP diode. In this paper we use LSP to explore methods of stabilizing the position and reducing the size of the radiographic spot.
Nano-Focusing and Leveling System Based on Improved Phase Analysis (2016)

A nano-focusing and leveling system (FLS) based on improved phase analysis is proposed to measure the wafer height in lithography. Different from traditional methods, this paper applies a grating-based mark to conduct the measurement according to the principle of the Moiré effect. The phase analysis is also improved based on the fringe frequency feature, which is quantitatively analyzed for the first time. As a result, the wafer height can be measured with nanoscale precision. Compared with the existing FLS, the proposed method can get higher precision. Both the simulations and experiments are carried out to verify the feasibility and accuracy of the proposed method.
Intracellular aspects of muscle cells of <i>Gallus gallus</i> at 72 hpi with 17DD virus. (2015)

&lt;p&gt;(A) Skeletal muscle cells detected by confocal microscopic analysis; (B) Airyscan super-resolution microscopy of the same field of view in a 0.16 μm optical slice showing a vesicular pattern of virus protein expression. Yellow fever virus proteins detected in green (A) or in white (B), nuclei stained with DAPI in blue (A).&lt;/p&gt;
TransBTS: Multimodal Brain Tumor Segmentation Using Transformer (2021)

Transformer, which can benefit from global (long-range) information modeling using self-attention mechanisms, has been successful in natural language processing and 2D image classification recently. However, both local and global features are crucial for dense prediction tasks, especially for 3D medical image segmentation. In this paper, we for the first time exploit Transformer in 3D CNN for MRI Brain Tumor Segmentation and propose a novel network named TransBTS based on the encoder-decoder structure. To capture the local 3D context information, the encoder first utilizes 3D CNN to extract the volumetric spatial feature maps. Meanwhile, the feature maps are reformed elaborately for tokens that are fed into Transformer for global feature modeling. The decoder leverages the features embedded by Transformer and performs progressive upsampling to predict the detailed segmentation map. Extensive experimental results on both BraTS 2019 and 2020 datasets show that TransBTS achieves comparable or higher results than previous state-of-the-art 3D methods for brain tumor segmentation on 3D MRI scans. The source code is available at https://github.com/Wenxuan-1119/TransBTS
Serum Vitamin D Concentration and Prostate Cancer Risk: A Nested Case-Control Study (2008)

The findings of this large prospective study do not support the hypothesis that vitamin D is associated with decreased risk of prostate cancer; indeed, higher circulating 25(OH)D concentrations may be associated with increased risk of aggressive disease.
Environmental Mycobacteriosis and Drinking Water: An Emerging Problem for Developed Countries (2009)

ISEE-0334 Background and Objective: Rates of pulmonary environmental mycobacteriosis (EM) appear to be increasing among developed countries during the past 20 years. EM is caused by multiple species of pathogenic mycobacteria that have been recovered from soil, water, water aerosols, biofilms and drinking water. Humans acquire infection primarily from environmental sources. Drinking water is one documented source of exposure implicated in human EM colonization and infection, but overall, the epidemiology of EM is poorly characterized. Our goal is to summarize and describe the evidence to date of the risk of pulmonary EM from exposure to drinking water sources. Methods: We performed a systematic review of the peer-reviewed literature. We included only those reports describing an epidemiologic and/or molecular association between human pulmonary EM and drinking water. Results: We identified 43 reports of pulmonary EM with documented drinking water sources of exposure in North America, Europe and Japan. Seventeen (40%) of these were associated with nosocomial exposures; 10 isolates from drinking water, 7 isolates from processed or modified drinking water. Fifteen (35%) reports described hot tub exposures. Nine (21%) reports described isolation from home drinking water. Multiple species of mycobacteria were isolated. Conclusion: Drinking water is a well-established source of EM. However, this review identified that many reports describe potential contamination events associated with drinking water quality that was modified after the original point of use; these include water processing, ice making machines, or drinking water further used for recreation or bathing. The extent of detection and reporting bias associated with these published reports is unknown. Population-based studies of individuals are needed to further characterize the risk of EM colonization and infection associated with drinking water exposures. This is an abstract of a proposed presentation and does not necessarily reflect EPA policy.