gebhart/patrepeval huggingface dataset:
Unsupervised Face Annotation by Mining the Web (2008)

Searching for images of people is an essential task for image and video search engines. However, current search engines have limited capabilities for this task since they rely on text associated with images and video, and such text is likely to return many irrelevant results. We propose a method for retrieving relevant faces of one person by learning the visual consistency among results retrieved from text correlation-based search engines. The method consists of two steps. In the first step, each candidate face obtained from a text-based search engine is ranked with a score that measures the distribution of visual similarities among the faces. Faces that are possibly very relevant or irrelevant are ranked at the top or bottom of the list, respectively. The second step improves this ranking by treating this problem as a classification problem in which input faces are classified as psilaperson-Xpsila or psilanon-person-Xpsila; and the faces are re-ranked according to their relevant score inferred from the classifierpsilas probability output. To train this classifier, we use a bagging-based framework to combine results from multiple weak classifiers trained using different subsets. These training subsets are extracted and labeled automatically from the rank list produced from the classifier trained from the previous step. In this way, the accuracy of the ranked list increases after a number of iterations. Experimental results on various face sets retrieved from captions of news photos show that the retrieval performance improved after each iteration, with the final performance being higher than those of the existing algorithms.
Mining the liver proteome for drug targets for sepsis* (2007)

National Jewish Medical and Research Center, Denver, CO The authors have not disclosed any potential conflict of interest.
Estimating the number of sources: An efficient maximization approach (2015)

Estimating the number of sources received by an antenna array have been well known and investigated since the starting of array signal processing. Accurate estimation of such parameter is critical in many applications that involve prior knowledge of the number of received signals. Information theoretic approaches such as Akaikes information criterion (AIC) and minimum description length (MDL) have been used extensively even though they are complex and show bad performance at some stages. In this paper, a new algorithm for estimating the number of sources is presented. This algorithm exploits the estimated eigenvalues of the auto correlation coefficient matrix rather than the auto covariance matrix, which is conventionally used, to estimate the number of sources. We propose to use either of a two simply estimated decision statistics, which are the moving increment and moving standard deviation as metric to estimate the number of sources. Then process a simple calculation of the increment or standard deviation of eigenvalues to find the number of sources at the location of the maximum value. Results showed that our proposed algorithms have a better performance in comparison to the popular and more computationally expensive AIC and MDL at low SNR values and low number of collected samples.
Phase I study of LY573636-sodium, an acylsulfonamide anti-cancer compound with a novel mechanism of action, administered as 2-hour IV infusion in patients with advanced solid tumors (2007)

2515 Background: LY573636 -sodium (hereafter referred to as LY573636 ) is a novel anti-cancer compound that induces apoptosis by a mitochondrial-mediated mechanism. Methods: A phase I study was conducted to determine the maximum tolerated dose (MTD) and pharmacokinetic (PK) profile of LY573636 administered as an intravenous infusion over 2 hours every 21 days. Results: 53 patients (pts) were enrolled on study, 16 males, 37 females, with a median age of 58 (range: 18–83). LY573636 was dose-escalated using a flat dosing paradigm in the first 34 patients (range 100 mg to 2400 mg). PK analysis of this cohort revealed that LY573636 had a low total plasma clearance (CL = 0.02L/hr) and terminal elimination half-life of approximately 340 hours due to high-albumin binding (∼99%). The dose limiting toxicity (DLT) for the flat dose escalation was bone marrow (BM) suppression, which included CTC (ver2) grade 3/4 thrombocytopenia/neutropenia. In some patients, significant BM suppression occurred in cycle 2 and later, attributed to the accumulation of albumin-bound drug with repeated flat dosing. Based on these findings, the dose-finding strategy was modified to an idealized dosing paradigm which calculated LY573636 doses based on pt lean body weight, and used a loading/maintenance dose regimen to achieve a specific Cmax target value. All 3 pts in the first 400 μg/mL Cmax cohort completed at least 2 cycles and no DLTs were reported. Of the 16 pts enrolled to the 420 μg/mL targeted dose group: 1 pt reported a DLT, a transient grade 3 elevation of ALT/AST which did not recur in subsequent cycles; 8/16 pts received 4 or more cycles prior to disease progression and 2 remain on treatment. Overall, 23/53 pts had stable disease (SD) after 2 or more cycles. Seven pts received &gt;8 cycles (SD &gt; 6 mos), including heavily pre-treated pts with ovarian cancer, non-small cell lung cancer, soft tissue sarcoma, and thymoma. Conclusions: LY573636 is a novel anti-cancer compound with a unique mechanism of action. The most common DLT was BM suppression. The individualized, target Cmax dose of 420 μg/mL has been taken forward into phase II clinical trials. No significant financial relationships to disclose.
Pankreaskarzinom 2018 – reif für personalisierte Therapiekonzepte? (2019)

Zusammenfassung Epidemiologie Die 5-Jahres-Überlebensrate (5-JÜR) aller Pankreaskarzinompatienten liegt mit rund 6 % sehr niedrig und die potenziell kurative Operation ist nur bei 15 – 20 % der Erkrankten möglich. Durch häufigeren Einsatz und Kombination systemischer Chemotherapeutika konnte in den letzten Jahren eine verbesserte Lebenserwartung erreicht werden. Resektables Stadium Nach vollständiger operativer Resektion eines Pankreaskarzinoms trägt eine adjuvante Chemotherapie zur Verlängerung des Gesamtüberlebens bei. Mittel der Wahl sind Gemcitabin oder 5-Fluorouracil (5-FU) und Folinsäure (FS). Kürzlich konnte für die Kombination aus Gemcitabin und Capecitabin (Gem-Cap) eine signifikante Verlängerung des Gesamtüberlebens im Vergleich zur Gemcitabin-Monotherapie gezeigt werden. Für den Einsatz einer adjuvanten Radiochemotherapie gibt es derzeit keine Empfehlung. Borderline-resektables Stadium Eine neoadjuvante Therapie hat bei Pankreaskarzinomen außerhalb klinischer Studien keinen Stellenwert. Eine Ausnahme stellen borderline-resektable Pankreaskarzinome dar. Fortgeschrittenes Stadium (M1) Patienten mit fortgeschrittenem oder metastasiertem Pankreaskarzinom profitieren von einer Chemotherapie. Für Patienten mit gutem ECOG-Status konnte kürzlich in 2 Phase-III-Studien eine signifikante Lebenszeitverlängerung durch die Kombination aus Gemcitabin plus nab-Paclitaxel (Gem-Nab) sowie durch das Kombinationsschema aus Folinsäure, 5-FU, Irinotecan und Oxaliplatin (FOLFIRINOX) gezeigt werden. In der Zweitlinie steht nanoliposomales Irinotecan oder Oxaliplatin kombiniert mit 5FU/FS (OFF) zur Verfügung. Personalisierte Therapien Die molekulare Charakterisierung des Pankreaskarzinoms hat Fortschritte gemacht und bietet schon heute Ansätze zur personalisierten Medizin. Bei gutem ECOG-Status sollte vor Zweitlinientherapie eine MSI-H/dMMR-Analyse erfolgen, um den möglichen Einsatz einer Checkpoint-Inhibitor-Therapie zu evaluieren. Bei BRCA-Mutationen kann die Gabe von PARP-Inhibitoren vielversprechend sein.
BDNF Promotes Differentiation and Maturation of Adult-born Neurons through GABAergic Transmission (2012)

Brain-derived neurotrophic factor (BDNF) has been implicated in regulating adult neurogenesis in the subgranular zone (SGZ) of the dentate gyrus; however, the mechanism underlying this regulation remains unclear. In this study, we found that Bdnf mRNA localized to distal dendrites of dentate gyrus granule cells isolated from wild-type (WT) mice, but not from Bdnf(klox/klox) mice where the long 3' untranslated region (UTR) of Bdnf mRNA is truncated. KCl-induced membrane depolarization stimulated release of dendritic BDNF translated from long 3' UTR Bdnf mRNA in cultured hippocampal neurons, but not from short 3' UTR Bdnf mRNA. Bdnf(klox/klox) mice exhibited reduced expression of glutamic acid decarboxylase 65 (a GABA synthase), increased proliferation of progenitor cells, and impaired differentiation and maturation of newborn neurons in the SGZ. These deficits in adult neurogenesis were rescued with administration of phenobarbital, an enhancer of GABA(A) receptor activity. Furthermore, we observed similar neurogenesis deficits in mice where the receptor for BDNF, TrkB, was selectively abolished in parvalbumin (PV)-expressing GABAergic interneurons. Thus, our data suggest that locally synthesized BDNF in dendrites of granule cells promotes differentiation and maturation of progenitor cells in the SGZ by enhancing GABA release, at least in part, from PV-expressing GABAergic interneurons.
Socially-aware gateway-based content sharing and backup (2011)

The amount of data that home users generate, store, and share with their friends via a multitude of devices has grown significantly in the past few years. In our paper, we assume that every household is equipped with a home gateway that stores and manages the data collected by the home users. To accelerate the content sharing and backup for such users, we propose an efficient backup scheme that hinges upon gateway interactions exploiting the users' social networking in- formation. We formulate this problem as a Budgeted Maximum Coverage (BMC) problem and we numerically compute the optimal content backup solution under a synthetic social network scenario. Then, we compare it with two different content placement strategies for gateways with various quota sizes, in a realistic synthetic social network.
Online Learning for Inexact Hypergraph Search (2013)

Online learning algorithms like the perceptron are widely used for structured prediction tasks.For sequential search problems, like left-to-right tagging and parsing, beam search has been successfully combined with perceptron variants that accommodate search errors (Collins and Roark, 2004;Huang et al., 2012).However, perceptron training with inexact search is less studied for bottom-up parsing and, more generally, inference over hypergraphs.In this paper, we generalize the violation-fixing perceptron of Huang et al. (2012) to hypergraphs and apply it to the cube-pruning parser of Zhang and McDonald (2012).This results in the highest reported scores on WSJ evaluation set (UAS 93.50% and LAS 92.41% respectively) without the aid of additional resources.
Application of the Wave Propagation Approach to Sandwich Structures: Vibro-Acoustic Properties of Aluminum Honeycomb Materials (2018)

Sandwich structures are manufactured using multiple combinations of materials for core and laminates. The real performances are influenced by variability in the composing layers and even by the uncertainties introduced while bonding them together. Therefore, experimental tests are usually the preferred way to assess the most important parameters required to develop and to characterize the product, the main downsides lying in their cost and time consumption. This work explores a practical application of the wave propagation approach by means of a case study, in which some significant properties of an aluminum honeycomb panel are obtained starting from simple vibro-acoustic tests carried out on beam specimens. After determining the frequency-dependent bending stiffness function, the sound transmission loss is predicted and compared with the experimental results obtained in sound transmission suites. The same vibro-acoustic tests are used to estimate the core shear modulus. Finally, a parametric study is proposed to show how this technique can be effectively used in the early design stage, when producing physical samples is often impossible due to time and money constraints. The method proved to be a reliable and powerful tool in all the tested applications, providing good results with limited computational effort.
Modeling and inverting radio occultation signals in the moist troposphere (2001)

Accurate modeling of radio occultation signals is performed by solving the Helmholtz equation with the use of a multiple‐phase‐screen technique. Refractivity is assumed spherically symmetric, and vertical profiles are reproduced from high‐resolution tropical radiosondes. As a result, the characteristics of the signals, which are important for their tracking in low Earth orbit, are evaluated: the spectral bandwidth, ∼50 Hz, and the random phase acceleration, ∼1000 Hz/s. The complex signals are inverted with the use of two radio holographic methods: back propagation and sliding spectral (radio optics). For the back propagation method, finding the position of the auxiliary trajectory which provides an unambiguous bending angle function of impact parameter appears to be a problem. For the sliding spectral method a simple technique, which takes into account the whole spectral content of the signal without identification and selection of local spectral maxima, is introduced and tested. The sliding spectral method allows for the stable reconstruction of bending angles and refractivity with vertical resolution of ∼0.5 km. The small‐scale laminated structure of refractivity results in propagation of radio occultation signals down to significantly lower observation altitudes than in the case of smooth refractivity. Information content of radio occultation signals at those low altitudes is important for the radio holographic inversions.
Effect of Oxalate on Function of Kidney Mitochondria (1989)

The effects of oxalate on kidney mitochondria were evaluated in vitro to test whether oxalate exposure leads to derangement(s) in mitochondrial function that could in turn promote the formation of kidney stones. Our previous studies demonstrated that oxalate is transported across the mitochondrial membrane via the dicarboxylate carrier. The present studies indicated that oxalate competitively inhibits the uptake and oxidation of exogenous malate and succinate in isolated mitochondria but has no effect on mitochondrial respiration in the presence of a mixture of glutamate plus malate or glutamate plus pyruvate. Oxalate attenuates the increase in mitochondrial respiration produced by the uncoupler CCCP or by the Ca2+ ionophore A23187, and the latter effect is more pronounced in kidney than in liver mitochondria. The apparent Ki of oxalate for the response to Ca2+ ionophore is 1.9 +/- 0.3 mM in kidney and 6.1 +/- 0.2 mM in liver mitochondria. Similarly, the ability of oxalate to attenuate calcium-induced swelling of mitochondria is more dramatic in kidney than in liver mitochondria (apparent KiS of 1.7 +/- 0.1 and 18.2 +/- 0.7 mM, respectively). Oxalate has no effect on the rate of calcium uptake by energized mitochondria or on the rate of ruthenium red-insensitive calcium efflux from mitochondria in either tissue. The above findings indicate that oxalate interacts with the inner mitochondrial membrane or with processes controlling membrane integrity to a greater extent in kidney than liver mitochondria. The effects of oxalate on membrane permeability or integrity may be more important than its effects on mitochondrial energy production or calcium sequestration in the pathogenesis of calcium oxalate microlith formation in the kidney.
Centralized Scheduling and Channel Assignment in Multi-Channel Single-Transceiver WiMax Mesh Network (2007)

The IEEE 802.16a standard defines WiMax mesh network, using the base station (BS) as a coordinator for the centralized scheduling. This paper proposes a centralized scheduling algorithm for WiMax mesh networks. In our scheme, each node has one transceiver and can be tuned between multiple channels, intending to eliminate the secondary interference for reducing the length of scheduling. We first study the problem when sufficient channels are supported, then extend our solution to the case with insufficient number of channels. Both the scheduling algorithm and the channel assignment strategies are included. The simulation results show that the multi-channel single-transceiver MAC can reduce the length of scheduling substantially as compared with the single channel system, and double channel may provide a performance similar to the multiple channels.
Isolation and characterization of a new strain ofCellulomonas flavigena (1990)

A cellulolytic bacterium was isolated from leaf litter. Its nutritional characteristics and most of its morphological features closely resemble those of ATCC # 482, which is considered to be the type species of Cellulo~ monasflavigena (Stackebrandt and Keddie in Bergey's Manual of Systematic Bacteriology). However, when stationary phase cells from cultures using a minimal medium containing an excess carbon and energy source are compared, a very prominent morphological difference is manifest. Phase contrast microscopy and transmission electron microscopy indicate the presence of large swollen polar structures in the type species. The absence of such structures from the new isolate and the production of large amounts of an extracellular polysaccharide indicate that it is a new strain of Cellulomonasflavigena.
Resting B cells from New Zealand Black mice demonstrate a defect in apoptosis induction following surface IgM ligation (1996)

New Zealand Black (NZB) mice spontaneously develop autoimmune disease, usually characterized by an autoimmune hemolytic anemia, and NZB genes are essential for a severe systemic lupus-like disease in (NZB x NZW)F1 mice. We have found that resting B cells from NZB mice demonstrate a pronounced defect, compared with five normal strains, in apoptosis induction after cross-linking with anti-IgM Abs. In contrast, spontaneous apoptosis of NZB B cells in culture was similar to normal strains. B cells from young (NZB x SM/J)F1 and (NZB x NZW)F1 mice underwent apoptosis normally, indicating that the NZB defect in apoptosis is a recessive trait. However, older (8-32 wk) predisease (NZB x NZW)F1 mice manifested a similar defect in apoptosis induction. The analysis of NXSM recombinant inbred mice derived from NZB and SM/J, in addition to backcross mice, suggested that the NZB apoptosis defect is a multigenic trait. Interestingly, resting B cells form B6.lpr and B6gld mice underwent apoptosis following anti-IgM treatment at a level similar to that of the C57BL/6 parental strain. Thus, the induced apoptosis of resting B cells and the NZB defect are likely not related to either Fas or Fas ligand. We propose that this phenotypic defect in apoptosis induction, or the biochemical alteration that underlies the defect, may be casually related to autoimmune disease in NZB mice and its contribution to lupus-like disease in (NZB x NZW)F1 mice.
Vapor-phase Graft-copolymerization of Methyl Methacrylate onto Polypropylene Fibers by Pre-irradiation Technique (1973)

前照射法を用いてポリプロピレン繊維に対するメタクリル酸メチルの気相グラフト重合を行ない,反庵過程をスプリングバランス法で追跡した。グラフト反応による繊維の重量増加はグラフト反応温度が高いほど低くなる。モノマーの蒸気圧およびγ線前照射線量が増加するとグラフト反応速度も増加する。一般に重量増加速度は反応時間の増加とともに徐々に低下するが,グラフト温度が低いときにはむしろ加速的に進行する。グラフト繊維は包含ホモポリマーをほとんど含んでいないことが知られた。反応過程におけるグラフト率の増加をグラフト率の増加にともなうモノ一収着量の増大を考慮した反応機構から説明した。段階的に徐冷したグラフト試料の示差走査熱量測定により再結晶におよぼすグラフト分枝の影響を検討した。
Nuez de Macadamia a Japón (2019)

Este trabajo surge de la interrogante de si es posible exportar nuez de macadamia a Jaon, y a partir de esa premisa es que se comienza a dar forma a un plan de negocios que implica una metodologia adecuada para su elaboracion. El presente proyecto constituye la parte de investigacion y documentacion necesaria para la elaboracion del p lan de negocios para la empresa Esfuerzo Campesino de la Montana S.C. de C.V., para exportar nuez de macadamia a Japon, ademas de las pertinentes proyecciones financieras para que tenga toda la informacion para una adecuada toma de decisiones en cuento a la inversion requerida. La empresa se encuentra ubicada en el municipio de Huatusco, lugar que se considera como uno de los principales productores de nuez de macadamia en el estado de Veracruz.
Gebüsche, Hecken, Waldmäntel, Feldgehölze (2004)

Hecken und Waldränder stellen komplexe Ökosysteme entlang eines starken Nutzungs- und Lichtgradienten dar. Auch Gebüsche und Feldgehölze zeichnen sich durch große Rand- und Übergangsbereiche aus. In Feldgehölzen finden aufgrund ihrer geringen Flächengröße und den überall wirksamen Randeinflüssen Offenlandarten Lebensräume. In diesen Landschaftsbestandteilen finden sich auf engem Raum sehr unterschiedliche Lebensbedingungen. Damit kommt ihnen eine große Bedeutung für den Artenschutz zu. In den meisten Bundesländern sind Hecken gesetzlich geschützt. Dennoch werden Hecken auch heute noch beseitigt. Eine “schleichende” Zurückdrängung und abschließende völlige Vernichtung durch Umnutzung des Standorts muss für intensiv genutzte Gebiete Deutschlands angenommen werden. Valide Bilanzierungen hierüber fehlen. Insbesondere Neupflanzungen im Rahmen von Maßnahmen der Flurneuordnung oder des Ausgleichs von umwelterheblichen Eingriffen sind hiervon betroffen Folgende Entwicklungsziele sind aus Sicht des Naturschutzes im Hinblick auf eine Pflege vorhandener und Schaffung neuer Strauchformationen anzustreben: (1) Landschaftsgestaltung, (2) Botanischer Artenschutz, (3) Botanischer Biotopschutz, (4) Zoologischer Arten- und Biotopschutz, (5) Integrierter Pflanzenschutz, (6) Ressourcenschutz und Landschaftsentwicklung.
A masking-threshold-adapted weighting filter for excitation search (1996)

Most LPC-based audio coders improve the reproduction quality by using predictor coefficients to embody perceptual masking in noise spectral shaping. Since the predictor coefficients were originally derived to characterize sound production models, they cannot precisely describe the human ear's nonlinear responses to frequency and loudness. We report on new approaches to exploiting the masking threshold in the design of a perceptual noise-weighting filter for excitation searches. To track the nonstationary evolution of a masking threshold, an autoregressive spectral analysis with finite order has been shown to be capable of providing sufficient accuracy. In seeking a faster response, an artificial neural network was also trained to extract autoregressive modeling parameters of the masking threshold from typical audio signals via mapping. Furthermore, we propose the concept of sinusoidal excitation representation to better track the intrinsic characteristics of prediction error signals. Simulation results indicate that the combined use of a multisinusoid excitation model and a masking-threshold-adapted weighting filter allows the implementation of an LPC-based audio coder that delivers near transparent quality at the rate of 96 kb/s.
Multiple Fano resonances in spoof localized surface plasmons (2014)

We present the occurrence of bright modes and dark modes in spoof localized surface plasmons (LSPs) generated by ultrathin corrugated metallic disks. As two such disks with asymmetric geometries are placed in close proximity, we find that dark modes (in multipoles) of one disk emerge by coupling with the bright modes (in dipoles) of the other disk. Then we further observe multiple Fano resonances due to destructive interferences of dark modes with the overlapping and broadened bright modes. These Fano line-shapes clearly exhibit the strong polarization dependence. We design and fabricate the ultrathin corrugated bi-disk structure in the microwave frequency, and the measurement results show reasonable agreement with theoretical predictions and numerical simulations. Such multiple Fano resonances could be exploited for the plasmonic devices at lower frequencies.
Non-oral pyogenic granuloma in pregnancy: a report of two cases. (1994)

Clinical experience suggests that the prevalence of pyogenic granulomas in pregnancy is not as high as has been reported in the literature. The relation of non-oral lesions to pregnancy is unknown.