gebhart/patrepeval huggingface dataset:
Pathways Controlling the Expression of Surface CD21 (CR2) and CD23 (FcεIIR) Proteins in Human Malignant B Cells (1997)

The aim of the present study was to analyze the pathways regulating the expression of CD21 and CD23 B-cell differentiation antigens on human malignant B cells. Exposure of Farage cells, derived from a human B-cell lymphoma, to phorbol 12-myristate 13-acetate (PMA) down-regulated CD21 and CD23 expression, while interleukin 4 (IL4) inhibited the expression of CD21 but augmented CD23 expression. When Farage cells were stained with either anti-CD21 or anti-CD23 monoclonal antibodies (mAb), subsequent exposure to IL4 failed to change the staining of the cells, indicating that IL4 did not affect the turnover of CD21 and CD23 molecules. Inhibition of protein synthesis with cycloheximide (CXM) had no effect on the expression of CD21 molecules, but abrogated their down-regulation by IL4, suggesting that IL4 induced the synthesis of proteins which modify the processing of CD21 molecules. The inhibitory effect of IL4 on the expression of CD21 and its augmentary effect on the expression of CD23 was abrogated by H7 (1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine), an inhibitor of serine protein kinase. Staurosporine, an additional inhibitor of serine kinases also abrogated the effect of IL4 on CD23 expression. H8 (N-(2-[Methylamino]ethyl)-5-isoquinolinesulfonamide), a preferential inhibitor of protein kinases A and G, and genistein, an inhibitor of tyrosine kinases had no effect on IL4-induced modulation of CD21 and CD23 in Farage cells. The exposure of B-chronic lymphocytic leukemia (CLL) cells to PMA reduced the expression of CD21, but increased the expression of CD23. IL4 had no effect on the expression of CD21 on CLL-cells but strongly enhanced the level of CD23. H7, H8 and genistein each abrogated to a different extent the effect of IL4 on the expression of CD23 by CLL-cells. These data indicate that activation of serine/threonine kinases in malignant B cells inhibited the production of CD21 proteins, while different protein kinases appeared to be involved in up- and down-regulation of CD23 in different B lymphocytes.
Structure and permeability of magnetoliposomes loaded with hydrophobic magnetic nanoparticles in the presence of a low frequency magnetic field (2011)

In this paper we describe the effect of a low frequency alternating magnetic field (LF-AMF) on the structure and permeability of magnetoliposomes, i.e. liposomes formulated in the presence of magnetic nanoparticles. Hydrophobic cobalt ferrite nanoparticles (CoFe2O4) coated with a shell of oleic acid were prepared, characterized and employed in the preparation of magnetoliposomes. The stability of the lipid bilayer after the application of an oscillating magnetic field was studied by means of Dynamic Light Scattering (DLS), Small Angle Scattering of X-rays (SAXS) and Differential Scanning Calorimetry (DSC). The enhancement of liposome permeability upon LF-AMF exposure was measured as the self-quenching decrease of the fluorescent molecule carboxyfluorescein (CF) entrapped in the liposome pool. Carboxyfluorescein leakage from magnetoliposomes was investigated as a function of field frequency, time of exposure to the magnetic field, and cobalt ferrite nanoparticles concentration. Kinetics of CF release from LF-AMF treated magnetoliposomes, monitored through the fluorescence intensity increase during time, highlights a slow release of CF during the first hours, followed by a faster release a few hours after the field treatment which leads to a complete leakage of CF. DSC provides insights about the effect of the LF-AMF treatment, showing that the first few hours correspond to a complete loss of the transition peak from the lamellar gel (Lβ) phase to the liquid crystalline (Lα) phase of the PC bilayers. These results suggest that the slow release takes place through the formation of local pores or defects at the membrane level, while the fast release corresponds to an increased permeability of the membrane that can be related to a structural change of the bilayer.
[Radiation moulage therapy of gingival tumors]. (1991)

An irradiation treatment technique, long ago known yet seldom employed, is reported on. With a patient, because of an inoperable gingiva-tumor, after percutan irradiation for complementary purpose radium-moulage treatment was employed. Due to the irradiation treatment the patient became symptomless.
Experimental preparation of an arbitrary tunable Werner state (2017)

We propose a simple and reliable method for engineering a tunable Werner state and realize it experimentally. The whole setup mainly includes a parametric down-conversion source and a controllable depolarization channel which consists of a Sagnac-like interferometer and some complete dephasing operations. The generated Werner states are characterized by quantum tomography, and very high concurrences and state fidelities can be achieved.
Real- time UAV weed scout for selective weed control by adaptive robust control and machine learning algorithm (2016)

<abstract> <b>Abstract.</b> Typically, herbicides are applied uniformly to the entire field rather than be applied to the critical areas where they‘re most needed. And existing weed identification approaches, such as manual visual scouting and ground-based proximal sensing, are labor intensive, time consuming, and do not scale easily to large areas. To facilitate more efficient farming, new technologies must be developed that can achieve optimal weed management and increase the crop yield by a magnitude. To date, rapid advances in UAV technology has enabled sufficient lifting capacity and endurance to support high resolution imagery over large areas. With the FAA planning to integrate UAVs into the national airspace (NAS), UAV-based aerial weed scouting is now possible to bring promising significant benefits for farmers. An unmanned aerial vehicle based aerial weed scout with machine vision system was proposed and developed for the weed identification with the sensing capability from far above the field to close to the canopy, and measuring the plant/weed density (weed infestation rate)/weed species. The canopy was segmented from the background by greenness selection and thresholding. The crop row and its centroid line was calculated and masked by its pixel density. The anomalous weed patches between the crop rows was identified and its population was mapped. For species identification, a machine learning approach is used. Convolutional Neural Network (CNN) as one of deep learning method has the advantage of less neuron weight, easy for training and good robust performance in displacement, scale and deformation, which is promising for the weed specifies classification and probability assessment. The previous weed distribution mapping and individual weed extraction helps to generate the training data and highlights their own features, which could ensure the weed identification classifier robustness and efficiency. The preliminary result shows the specific weed type could be classified probably. The results show that the proposed approach will provide an efficient and promising tool for farmers‘ weed identification and the resulting infestation mapping will enable a better weed control recommendation.<b><sc> </sc></b>
Sulfuryl Fluoride Promoted Thiocyanation of Alcohols: A Practical Method for Preparing Thiocyanates (2020)

A novel SO2F2-promoted thiocyanation method for the one-step synthesis of thiocyanates through C–O bond cleavage of readily available alcohols with ammonium thiocyanate as the thiocyanating agent was developed. The method avoids the use of additional catalyst, and a variety of (hetero)arene, alkene and aliphatic alcohols reacted with high efficiency in ethyl acetate under mild conditions to afford the corresponding thiocyanates in excellent to quantitative yields with broad functional-group compatibility.
Bio-inspired hybrid microelectrodes: a hybrid solution to improve long-term performance of chronic intracortical implants (2014)

The use of implants that allow chronic electrical stimulation and recording in the brain of human patients is currently limited by a series of events that cause the deterioration over time of both the electrode surface and the surrounding tissue. The main reason of failure is the tissue inflammatory reaction that eventually causes neuronal loss and glial encapsulation, resulting in a progressive increase of the electrode-electrolyte impedance. Here, we describe a new method to create bio-inspired electrodes to mimic the mechanical properties and biological composition of the host tissue. This combination has a great potential to increase the implant lifetime by reducing tissue reaction and improving electrical coupling. Our method implies coating the electrode with reprogrammed neural or glial cells encapsulated within a hydrogel layer. We chose fibrin as a hydrogel and primary hippocampal neurons or astrocytes from rat brain as cellular layer. We demonstrate that fibrin coating is highly biocompatible, forms uniform coatings of controllable thickness, does not alter the electrochemical properties of the microelectrode and allows good quality recordings. Moreover, it reduces the amount of host reactive astrocytes - over time - compared to a bare wire and is fully reabsorbed by the surrounding tissue within 7 days after implantation, avoiding the common problem of hydrogels swelling. Both astrocytes and neurons could be successfully grown onto the electrode surface within the fibrin hydrogel without altering the electrochemical properties of the microelectrode. This bio-hybrid device has therefore a good potential to improve the electrical integration at the neuron-electrode interface and support the long-term success of neural prostheses.
A broadly protective anti-influenza neuraminidase monoclonal antibody (VAC11P.1100) (2015)

Abstract Hemagglutinin (HA) and neuraminidase (NA) are the major surface glycoproteins of influenza viruses and the main targets of vaccine-induced antibodies (Abs). While several broadly neutralizing anti-HA Abs can cross-protect against diverse influenza subtypes, NA-specific Abs could only protect partially against strains from the same subtype. Through comprehensive bioinformatics analyses of all publicly available influenza A and B NA sequences, we found a universally conserved 9-mer peptide (ILRTQESEC) amongst all influenza NA proteins (amino acids 222-230). Growth kinetics of recombinant viruses with single alanine substitutions within this epitope proved its crucial roles in viral fitness and replication. Importantly, a monoclonal Ab (HCA-2 mAb) raised against this sequence showed broad in vitro inhibition against multiple strains from all influenza A NA subtypes (N1-N9) and influenza B lineages. It also provided in vivo heterosubtypic protection against lethal doses of H1N1 and H3N2 strains. Amino acid residues I222 and E227, located in close proximity to the active site, were found to be indispensable for inhibition by HCA-2 mAb. These findings reveal the essential role of this highly-conserved sequence in NA function and viral replication and show that it is sufficiently exposed to allow access of inhibitory Abs during the course of infection. Thus, it could represent a potential target for novel antivirals or vaccines against diverse strains of influenza A and B viruses.
The Behavior of Zeta Potential of Silica Suspensions (2014)

Zeta potential is one of the most relevant parameters controlling the rheological behavior of ceramic suspensions. In this work, it was observed that for pH values below the isoelectric point (IEP), the positive value of zeta potential of water suspensions of α-quartz and α-cristobalite, experiences a sudden steep increase with the increase in specific surface area of the powders. For pH values above the IEP, the zeta potential values of crystalline forms of silica (α-quartz and α-cristobalite), get gradually more negative with the increase in pH. Conversely in the case of vitreous silica, for pH values above 6, there occurs a steep change towards more negative values of zeta potential than those presented by quartz and cristobalite. These findings have not yet been accounted for in the DLVO theory but may provide subsidies for better understanding of how to stabilize and destabilize crystalline and vitreous silica water suspensions.
Inhomogeneous Degradation of Graphite Anodes in Li-Ion Cells: A Postmortem Study Using Glow Discharge Optical Emission Spectroscopy (GD-OES) (2016)

Durability and performance of Li-ion cells are impaired by undesirable side reactions, observed as capacity decreases and resistance increases during their usage. This degradation is caused by aging mechanisms on the material level including surface film formation, especially in the case of graphite-based anodes. The present study evaluates the applicability of glow discharge optical emission spectroscopy (GD-OES) as a powerful tool to study aging-induced film formation on graphite anodes of Li-ion cells, including deposition of metallic Li. The technique provides depth-resolved information on the elemental distribution in the samples from the anode surface to the current collector (through-plane resolution). Additionally, conducting GD-OES depth profiling at different positions of an aged graphite anode reveals differences in surface film growth across the anode plane (in-plane resolution). After verification of the GD-OES method by well-established analytical techniques, aged anodes from commercial state-of-the-art Li-ion cells are analyzed. The results show through-plane and in-plane inhomogeneity in surface film growth: local island-like Li deposition is revealed for 16Ah pouch cells cycled at 45 °C and high charging current density while a more homogeneous Li plating gradient is found for cycling 26650-type cells at −20 °C.
Visual and odour cues: plant responses to pollination and herbivory affect the behaviour of flower visitors (2015)

Summary Plants evolved strategies to attract pollinators that are essential for reproduction. However, plant defence against herbivores may trade off with pollinator attraction. Here, we investigated the role of inducible plant secondary metabolites in such a trade‐off. Our objective was to reveal the mechanisms underlying the effects of induced plant responses to pollination and herbivory. We assessed how responses of plants to pollination and insect herbivory affect the behaviour of flower visitors. Subsequently, we investigated how the production of volatile and non‐volatile compounds changes after pollination and herbivory. Both herbivores and pollinators induced important phenotypic changes in flowers. Brassica nigra plants respond to pollination and herbivory with changes in the profile of volatiles and non‐volatiles of their flowers. Our results show that butterflies use different cues when searching for an oviposition site or a nectar source. Pollination status influenced the behaviour of butterflies, but not that of syrphid flies. We discuss the results in the context of the trade‐off between defence and reproduction in plants and suggest that systemic responses to herbivores can interfere with local responses to pollination. Therefore, these responses must be addressed in an integrated way because, in nature, plants are simultaneously exposed to herbivores and pollinators.
Analysis of communication requirements for intelligent transportation systems: methodology and examples (2002)

The intelligent transportation system (ITS) utilizes technological advances in computers, electronics, and communications in order to improve the effectiveness of the entire surface transportation system. The communication system which connects all of the ITS components has to be adequate in addressing the user requirements. The definition and analysis of the ITS communication system is essential to demonstrate the ability of an ITS architecture in providing all of the intended user services. In this paper, we define the subsystems of an ITS physical architecture and perform data loading analysis on the RF communication link between the vehicles and the infrastructure.
Highly Diastereo‐ and Enantioselective Synthesis of 5‐Substituted 3‐Pyrrolidin‐2‐ones: Vinylogous Michael Addition under Multifunctional Catalysis (2011)

A direct line: A direct organocatalytic asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactams with α,β-unsaturated ketones has been developed (see scheme; Boc=tert-butoxycarbonyl, Trp=tryptophan, Ts=4-toluenesulfonyl). The resulting Michael products, 5-substituted 3-pyrrolidin-2-ones, could be obtained in excellent yields with excellent enantio- and diastereoselectivity. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Limits of Smart Radio Resource Assignment in GEO Satellite Communications (2021)

In this paper, the limits in terms of offered capacity for a non-precoded geostationary (GEO) satellite communication system is investigated. In particular, we focus on the smart radio resource assignment as a technique to manage the interference across the multi-beam pattern of the GEO system. In this context, a joint power and carrier allocation problem is formulated to maximize the capacity of the system. The formulated optimization problem is non-convex and difficult to solve. Hence, we propose to address the frequency allocation first by assuming an equal power distribution, followed by the optimal power assignment to maximize the sum-capacity. Numerical evaluations are presented comparing the proposed method with a precoded-based system and with benchmark resource allocation schemes, showing the benefits of the proposed technique and identifying the limits of a non-precoded GEO satellite communications system.
Statistical investigations of an ENIG Nickel film morphology by Atomic Force Microscopy (2016)

The morphology of a Nickel layer grown by an Electroless Nickel Immersion Gold (ENIG) technique used for microelectronics interconnections is determined by Atomic Force Microscopy (AFM) investigations. The root mean square (rms) roughness, determined over a scanned area is a function of the AFM scanned area size. In this work, we propose to consider the dynamic scale theory and the power spectrum density (PSD) analysis in order to perform a comprehensive determination of the surface properties of the ENIG nickel layer. Results highlight the existence of a first regime with a roughness exponent of 0.95 and a fractal dimension (DF) of the nickel film about 2.05. This case study is presented in order to propose further investigations. In fact, same experimental procedure should be performed in a magnetic shielded zone where a very low noise level is available such as the Low-Noise Underground Laboratory (LSBB) of Rustrel (France).
Random-access communication with multiple reception (1990)

Communication over a random multiple-access (RMA) broadcast channel with multiple reception capability is considered. Multiple reception refers to the assumption that a collision is defined as the simultaneous transmission of more than d packets, where d>or=2. In most previous studies of RMA channels, it was assumed that d=1, that is, whenever more than one source tries to use the same slot, a collision occurs, and all the messages involved must be retransmitted. In practice, however, it might be possible to construct RMA systems where simultaneous transmission of d or fewer packets, where d>or=2, is successful. In this work, the author presents conflict resolution algorithms and determine lower bounds to the capacity of such RMA channels for many different feedback models. It is shown that the packet transmission rates (throughput) reported previously can be achieved under much less restricted feedback models.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Inhibition of late sodium current attenuates ionic arrhythmia mechanism in ventricular myocytes expressing LaminA-N195K mutation (2016)

Inhibition of late I<sub>Na</sub> may be an effective therapy in preventing arrhythmia in patients with LmnaN195K mutation-related DCM.
The Effect of Newer Generation Lithotripsy Upon Renal Function Assessed by Nuclear Scintigraphy (1995)

Newer generation lithotriptors may limit renal damage while permitting satisfactory treatment of renal calculi.
Synthesis and spectroscopic characterization of cadmium(II) complexes of thiones and thiocyanate (2008)

Cadmium(II) complexes of thiones and thiocyanate, [(>C=S)2Cd(SCN)2], have been prepared and characterized by IR and NMR spectroscopy. An upfield shift in the >C=S resonance of thiones in the 13C NMR and downfield shift in N–H resonance in 1H NMR are consistent with sulfur coordination to cadmium(II). The presence of ν(N–H) of thiones in IR spectra of the complexes indicates the thione forms of the ligands in the solid state; some contribution of the thiolate form was observed in one complex. The appearance of a band around 2100 cm−1 in IR and a resonance around 132 ppm in 13C NMR indicates the binding of thiocyanate to cadmium(II).
Coherent array processing of gps sonobuoys (2010)

Underwater target tracking in ocean environment has attracted considerable interest in both military and civilian applications.Towards this purpose, sonobuoys are among the most capable sonar systems used in underwater environments.Sonobuoys are used to detect and track underwater objects emitting sounds.Recently GPS receivers have been integrated to sonobuoy systems to provide accurate information about sonobuoys positions.An accurate knowledge of geographic positions of deployed sonobuoys is critical for the conduct of antisubmarine warfare (ASW) operations and detected target localization.It enables processing array of GPS sonobuoys thus improving the target tracking accuracy.Considering that sonobuoy positions are accurately known, the main factors influencing the operation of sonobuoys would be the interference sources and background noise.professional supervision, critical discussions and immeasurable contributions.I would
Problem localization strategies for pragmatics processing in natural-language front ends (1984)

Problem localization is the identification of the most significant failures in the AND-OR tree resulting from an unsuccessful attempt to achieve a goal, for instance, in planning, backward-chaining inference, or top-down parsing. We examine heuristics and strategies for problem localization in the context of using a planner to check for pragmatic failures in natural language input to computer systems, such as a cooperative natural language interface to Unix™ Our heuristics call for selecting the most hopeful branch at ORs, but the most problematic one at ANDs. Surprise scores and special-purpose rules are the main strategies suggested to determine this.