gebhart/patrepeval huggingface dataset:
Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy (2023)

Mutations in genes encoding nuclear envelope proteins lead to diseases known as nuclear envelopathies, characterized by skeletal muscle and heart abnormalities, such as Emery-Dreifuss muscular dystrophy (EDMD). The tissue-specific role of the nuclear envelope in the etiology of these diseases has not been extensively explored. We previously showed that global deletion of the muscle-specific nuclear envelope protein NET39 in mice leads to neonatal lethality due to skeletal muscle dysfunction. To study the potential role of the Net39 gene in adulthood, we generated a muscle-specific conditional knockout (cKO) of Net39 in mice. cKO mice recapitulated key skeletal muscle features of EDMD, including muscle wasting, impaired muscle contractility, abnormal myonuclear morphology, and DNA damage. The loss of Net39 rendered myoblasts hypersensitive to mechanical stretch, resulting in stretch-induced DNA damage. Net39 was downregulated in a mouse model of congenital myopathy, and restoration of Net39 expression through AAV gene delivery extended life span and ameliorated muscle abnormalities. These findings establish NET39 as a direct contributor to the pathogenesis of EDMD that acts by protecting against mechanical stress and DNA damage.
Acrylic Acid 의 반응추출에 미치는 용매의 영향 (1998)

In physical and reactive extraction of acrylic acid using various solvents the equilibrium characteristics of extraction were investigated. The degree of extraction in reactive extraction with Tri-n-octylamine(TOA) was 1.5∼3 times than that in physical extraction. Distribution ratio was constant in methyl isobutyl ketone(MIBK) and n-butylacetate(n-BAc) but was increased with increasing the concentration of acrylic acid in benzene and chloroform. It can be explained by formation of dimers. Maximum extraction loadings of acrylic acid were three in benzene and were two in MIBK, chloroform and n-BAc, and it was found that acrylic acid was extracted as the form of A_3R in benzene and A_2R in MIBK, chloroform and n-BAc. In effect of solvent, the degree of extraction was increased as the difference of solubility parameter of solvent and solute was decreased, and as dielectric constant of solvent was increased.
Evaluating Row Buffer Locality in Future Non-Volatile Main Memories (2018)

DRAM-based main memories have read operations that destroy the read data, and as a result, must buffer large amounts of data on each array access to keep chip costs low. Unfortunately, system-level trends such as increased memory contention in multi-core architectures and data mapping schemes that improve memory parallelism may cause only a small amount of the buffered data to be accessed. This makes buffering large amounts of data on every memory array access energy-inefficient. Emerging non-volatile memories (NVMs) such as PCM, STT-RAM, and RRAM, however, do not have destructive read operations, opening up opportunities for employing small row buffers without incurring additional area penalty and/or design complexity. In this work, we discuss architectural changes to enable small row buffers at a low cost in NVMs. We provide a memory access protocol, energy model, and timing model to enable further system-level evaluation. We evaluate the system-level tradeoffs of employing different row buffer sizes in NVM main memories in terms of energy, performance, and endurance, with different data mapping schemes. We find that on a multi-core CMP system, reducing the row buffer size can greatly reduce main memory dynamic energy compared to a DRAM baseline with large row sizes, without greatly affecting endurance, and for some memories, leads to improved performance.
ChemInform Abstract: Reaction of 5‐Hydroxyimino‐1,3‐dioxine‐4,6‐dione (Isonitroso Meldrum′s Acid) with Carbodiimides to Give Parabanic Acids. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Transpedicle Instrumentation in the Degenerative Spine (1997)

Controversy continues regarding the use of pedicle instrumentation in fusion surgery on the degenerative lumbar spine. Recently, however, published reports are increasingly demonstrative of the positive effect of pedicle fixation on fusion and outcome success in the management of these disorders. Recent developments in surgical technique and implant design have improved operative risk and implant related complications. However, patient selection and demonstration of the underlying pathophysiology of degenerative lumbar motion segment pain remain 2 of the main challenges to clinical practice. The importance of well designed clinical studies are of paramount consequence in the solution of the existing controversies surrounding surgical treatment of the degenerative lumbar spine. Equally significant is the need to establish general and accepted measures of outcome to assess and compare treatment options. Combining study design and accepted outcome assessment will permit the resolution of the remaining controversies. The future of pedicle instrumentation of the degenerative lumbar spine is of necessity tied to the resolution of these remaining points of controversy-only thereafter can the current rate of advances continue.
Gold‐Mediated Isomerization of Cyclooctyne to Ring Fused Olefinic Bicycles (2016)

Abstract Isomerization reactions of cyclooctyne mediated by N‐heterocyclic carbene supported gold(I) leading to ring‐contraction and the formation of 5/5‐fused bicyclic alkenes have been observed. Isolation and complete characterization, including X‐ray structural data of the cationic gold(I) complexes featuring the precursor alkyne and the product alkenes are also described.
Building Diversity in a Complex Academic Health Center (2013)

For 30 years, the many diversity-related health sciences programs targeting the University of Pittsburgh undergraduate campus, school of medicine, schools of the health sciences, clinical practice plan, and medical center were run independently and remained separate within the academic health center (AHC). This lack of coordination hampered their overall effectiveness in promoting diversity and inclusion. In 2007, a group of faculty and administrators from the university and the medical center recognized the need to improve institutional diversity and to better address local health disparities. In this article, the authors describe the process of linking the efforts of these institutions in a way that would be successful locally and applicable to other academic environments. First, they engaged an independent consultant to conduct a study of the AHC's diversity climate, interviewing current and former faculty and trainees to define the problem and identify areas for improvement. Next, they created the Physician Inclusion Council to address the findings of this study and to coordinate future efforts with institutional leaders. Finally, they formed four working committees to address (1) communications and outreach, (2) cultural competency, (3) recruitment, and (4) mentoring and retention. These committees oversaw the strategic development and implementation of all diversity and inclusion efforts. Together these steps led to structural changes within the AHC and the improved allocation of resources that have positioned the University of Pittsburgh to achieve not only diversity but also inclusion and to continue to address the health disparities in the Pittsburgh community.
ChemInform Abstract: A Microporous Carbon Produced by Arc‐Evaporation. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Grade 2 meningioma and radiosurgery (2015)

Radiosurgery appears to be a safe and effective treatment for the local control of delayed progression after resection of a Grade 2 meningioma. Higher radiation doses similar to those applied for malignant tumors should be recommended when possible.
Model Reference Robust Control of A Class of SISO Systems (1992)

In this paper, a new control design technique, model reference robust control, is introduced for a class of SISO systems which contain unknown parameters, possible nonlinearities, and additive bounded disturbances. The proposed design methodology is a natural but nontrivial extension of model reference adaptive control. Such an extension is not only essential to achieve robust stability and performance for linear time-invariant systems but also presents a further step toward achieving robust stability for time-varying or even nonlinear systems. The designed model reference robust control requires only input and output measurements of the system, compared with the full state feedback and structural conditions on uncertainties required by existing robust control results.
[Experimental morphological study of posttraumatic proliferative vitreoretinopathy prevention by cell adhesion peptide Arg-Gly-Asp-Ser]. (1997)

Proliferative vitreoretinopathy (PVR) was induced in 25 rabbits by injection of autologous adenosine phosphate-activated platelets in the vitreous. Injury to the internal interface retinal membrane as a result of adhesion of aggregated platelets to it, followed by the formation of an epiretinal membrane, underlies the morphogenesis of experimental PVR. Proliferative processes in the retina were paralleled by destructive atrophic changes in it, which might be due to active physiological substances released in the course of aggregation. The development of PVR was inhibited by a synthetic peptide of cell adhesion with Arg-Gly-Asp-Ser amino acid sequence, which was injected simultaneously with autologous activated platelets. Possible receptor mechanisms underlying the phenomenon of inhibition of the proliferative process in the retina of experimental animals are discussed.
Searching for common sequence patterns among distantly related proteins (1995)

We have developed a program Gap Allowing Pattern Explorer (GAPE) to extract amino acid sequence motifs conserved among distantly related proteins. The GAPE program is designed to allow gaps in the sequences. First, this program generates all possible amino acid patterns comprising up to five amino acids. Sequences containing the amino acid residues in the same order as a generated pattern are selected as subsequences, where the differences in the distances between two consecutive amino acids are ignored. Next, the motifs are extracted from the subsequences under conditions in which all four distances between the five amino acids are fixed. At this stage, motifs with gaps in their subsequence are also found by relaxing one of the four fixed distances. The statistical significance for a motif obtained is calculated based on the amino acid composition of the sequences under consideration. When the GAPE program was applied to 59 pyridoxal-phosphate-related sequences and 64 ATP (AMP-forming)-related sequences, motifs extracted with a low expectation of occurrence contained some of the amino acid residues chemically proved to be involved in the ligand recognition.
The beauty of capturing faces: Rating the quality of digital portraits (2015)

Digital portrait photographs are everywhere, and while the number of face pictures keeps growing, not much work has been done to on automatic portrait beauty assessment. In this paper, we design a specific framework to automatically evaluate the beauty of digital portraits. To this end, we procure a large dataset of face images annotated not only with aesthetic scores but also with information about the traits of the subject portrayed. We design a set of visual features based on portrait photography literature, and extensively analyze their relation with portrait beauty, exposing interesting findings about what makes a portrait beautiful. We find that the beauty of a portrait is linked to its artistic value, and independent from age, race and gender of the subject. We also show that a classifier trained with our features to separate beautiful portraits from non-beautiful portraits outperforms generic aesthetic classifiers.
High Power Semiconductor Disk Lasers (2006)

Results on high-power optically pumped semiconductor disk lasers are reviewed. Multi-Watt emission with differential efficiencies larger than 40% and power-densities up to 15 kW/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> is demonstrated in the near-infrared wavelength range of 920-1050 nm
ChemInform Abstract: REBe2B5O11 (RE: Y, Gd): Rare‐Earth Beryllium Borates as Deep‐Ultraviolet Nonlinear‐Optical Materials. (2014)

Abstract Colorless block single crystals of the title compounds are obtained from a melt of Y 2 O 3 or Gd 2 O 3 , BeO, B 2 O 3 , and Li 2 O (Pt crucible, 1100 °C).
LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia (2015)

An LKB1-dependent signalling cassette, involving but not restricted to AMPKα1, is required in pancreatic alpha cells for the control of glucagon release by glucose.
Inductive Single-Electron Transistor (2004)

We demonstrate a sensitive method of charge detection based on radio-frequency readout of the Josephson inductance of a superconducting single-electron transistor. Charge sensitivity 1.4 x 10(-4) e/square root Hz, limited by a preamplifier, is achieved in an operation mode which takes advantage of the nonlinearity of the Josephson potential. Owing to reactive readout, our setup has more than 2 orders of magnitude lower dissipation than the existing method of radio-frequency electrometry. With an optimized sample, we expect uncoupled energy sensitivity below variant Planck's over h in the same experimental scheme.
Nitrogen Removal by Anammox Biofilm Column Reactor at Moderately Low Temperature (2017)

The anaerobic ammonium oxidation (anammox) as a new biological approach for nitrogen removal has been considered to be more cost-effective compared with the combination of nitrification and denitrification process. However, the anammox bioreactors are mostly explored at high temperature (&gt;300C) in which temperature controlling system is fully required. This research was intended to develop and to apply anammox process for high nitrogen concentration removal at ambient temperature used for treating wastewater in tropical countries. An up-flow biofilm column reactor, which the upper part constructed with a porous polyester non-woven fabric material as a carrier to attach the anammox bacteria was operated without heating system. A maximum nitrogen removal rate (NRR) of 1.05 kg-N m3 d-1 was reached in the operation days of 178 with a Total Nitrogen (TN) removal efficiency of 74%. This showed the biofilm column anammox reactor was successfully applied to moderate high nitrogen removal from synthetic wastewater at moderately low temperature. Keywords: Anammox, biofilm column reactor, ambient temperature, nitrogen removal
Reduction of Cu2O nanocrystals: reactant-dependent influence of capping ligands and coupling between adjacent crystal planes (2011)

A systematic study of the reduction behavior of various types of uniform Cu2O nanocrystals reveals that the surface blocking effect exerted by the capping ligand on the reduction behavior of the Cu2O nanocrystals depends not only on the type of capping ligand but also on the reactant and that coupling between adjacent crystal planes occurs for Cu2O nanocrystals exposing two types of crystal planes during the reduction reactions and exerts great influence on the reduction kinetics of the involved crystal planes.
TerraSAR-X in-orbit antenna model verification results (2007)

TerraSAR-X is a highly flexible X-band radar satellite. Its primary objective is the acquisition of high quality SAR images in a multitude of possible acquisition modes. The great amount of antenna patterns needed for image acquisition requires an antenna model accurately describing all beams. To guarantee the required image quality, the model is verified in-orbit. As TerraSAR-X is scheduled for launch in June 2007, this paper will present the necessity of the antenna model and the methods to verify it.
Optimal multicast scheduling in input-queued switches (2002)

This paper focuses on multicast support in input-queued packet switches with internal multicast capabilities. Besides providing an overview of some alternative architectures and algorithms proposed in the literature, the paper brings two original contributions. First, multicast traffic admissibility conditions are defined, and theorems showing intrinsic performance losses of input-queued with respect to output-queued switch architectures are proved. Second, the optimal scheduling discipline in transferring multicast packets from switch inputs to switch outputs is defined. From the definition of the optimal multicast scheduling discipline, the formal characterization of the sustainable multicast traffic region naturally follows. Both results aim at a correct formal definition of the considered problem, in order to identify a sound starting point for the design of heuristics that approximate the optimal solution at a complexity compatible with available technologies.
Emotion-Based End-to-End Matching Between Image and Music in Valence-Arousal Space (2020)

Both images and music can convey rich semantics and are widely used to induce specific emotions. Matching images and music with similar emotions might help to make emotion perceptions more vivid and stronger. Existing emotion-based image and music matching methods either employ limited categorical emotion states which cannot well reflect the complexity and subtlety of emotions, or train the matching model using an impractical multi-stage pipeline. In this paper, we study end-to-end matching between image and music based on emotions in the continuous valence-arousal (VA) space. First, we construct a large-scale dataset, termed Image-Music-Emotion-Matching-Net (IMEMNet), with over 140K image-music pairs. Second, we propose cross-modal deep continuous metric learning (CDCML) to learn a shared latent embedding space which preserves the cross-modal similarity relationship in the continuous matching space. Finally, we refine the embedding space by further preserving the single-modal emotion relationship in the VA spaces of both images and music. The metric learning in the embedding space and task regression in the label space are jointly optimized for both cross-modal matching and single-modal VA prediction. The extensive experiments conducted on IMEMNet demonstrate the superiority of CDCML for emotion-based image and music matching as compared to the state-of-the-art approaches.
Human papillomavirus vaccines: who will pay, who will receive, when to administer? (2007)

The availability of a prophylactic human papillomavirus (HPV) vaccine for the prevention of cervical cancer and its precursors offers the potential to reduce cervical cancer incidence, mortality, and related morbidity. In addition, HPV vaccination has the potential to reduce existing cervical cancer disparities. Policy and implementation issues, including vaccine funding and identification of whom to vaccinate and when, will affect the success of HPV vaccination in achieving its potential. While many public and private programs are available to cover the costs of vaccination, each has challenges and limitations. The high cost of the HPV vaccine in particular will substantially add to the burden of vaccine financing and delivery. Even as HPV vaccination for the prevention of cervical cancer is introduced and promoted, it remains critical that women undergo regular screening regardless of whether they have been vaccinated.
Exact analysis of co-channel interference in a shadowed-Nakagami/shadowed-Rician channel model (2002)

To characterize the transmission environment of a microcellular system, ideally we would like to use a model which allows the line-of-sight component in both the desired and interfering signals, i.e. Rican signals. It should also allow different Rice factors, different shadowing spreads, and even different transmitted powers (i.e. irregular cell sizes). The problem, however, is that an exact analysis of such a shadowed-Rician (desired)/shadowed-Rician (interfering) model containing all the variations mentioned above hasn't been found. We show the exact analysis of a model of a similar kind-the only difference is that the the Rican desired signal is replaced by a Nakagami signal. That is, we offer an exact analysis for a shadowed-Nakagami (desired)/shadowed-Rican (interfering) model. It has been shown that a Rican distribution can be closely approximated by a Nakagami distribution. The offered analytical technique can be viewed as a good approximation for a shadowed-Rican (desired)/shadowed-Rican (interfering) model. The model we analyze also includes all the previously mentioned flexibilities-different Rice factors, different shadowing spreads and different cell sizes.
Statistical analysis and transfer of coarse-grain pictorial style (2005)

We show that image statistics can be used to analyze and transfer simple notions of pictorial style of paintings and photographs. We characterize the frequency content of pictorial styles, such as multi-scale, spatial variations, anisotropy properties, us-ing a multi-scale and oriented decomposition, the steerable pyramid. We show that the average of the absolute steerable coefficients as a function of scale characterizes simple notions of &amp;quot;look &amp;quot; or style. We extend this approach to account for image non-stationarity, that is, we capture and transfer the spatial variations of multi-scale content. In addition, we measure the standard deviation of the steerable coefficients across orientation, which characterizes image anisotropy and permits analysis and transfer of oriented structures. We focus on the statistical features that can be transferred. Since we couple analysis and transfer, our statistical model and transfer tools are consistent with the visual effect of pictorial styles. For this reason, our technique leads to more intuitive ma-nipulation and interpolation of pictorial styles. In addition, our statistical model can
Bunch Length Measurements Using Coherent Smith-Purcell Radiation With Several Gratings at CLIO (2018)

Coherent Smith Purcell radiation allows the measurement of a beam longitudinal profile through the study of the emission spectrum of the radiation emitted when a grating is brought close from the beam. In order to increase the dynamic range of our measurements we have used several gratings and we report on the measured bunch form factor using this technique. We report on these measurements and on the background rejection used.
SENSITIVE PARAMETER DEPENDENCE OF AUTOCORRELATION FUNCTION IN PIECEWISE LINEAR MAPS (2007)

This paper is principally concerned with the effect of splitting and permuting, or shifting, the branches of an onto piecewise linear map, with particular regard to the effect on the autocorrelation of the associated chaotic sequence. This is shown to be a chaotic function of the shifting parameter of the map, and its sensitivity with respect to minute changes in this parameter is termed autocorrelation chaos. This paper presents both analytical and computational studies of the phenomenon.