gebhart/patrepeval huggingface dataset:
Towards a self-assembled honeycomb structure via diaminotriptycene metal complexes (2013)

We illustrate a new approach toward the synthesis of a porous supramolecular honeycomb based on triptycene. A coordination polymer has been prepared where the triptycene groups are linked through triptycenesemiquinonediimine platinum complexes, but the product is disordered rather than the intended honeycomb structure. A model platinum complex and its (15)N-labeled isotopomer have been prepared and characterized.
Pneumolysin Is the Main Inducer of Cytotoxicity to Brain Microvascular Endothelial Cells Caused by Streptococcus pneumoniae (2001)

In pneumococcal meningitis it is assumed that bacteria cross the blood-brain barrier (BBB), which consists mainly of cerebral endothelial cells. The effect of Streptococcus pneumoniae on the BBB was investigated with an in vitro BBB model using a human brain microvascular endothelial cell line (HBMEC) and primary cultures of bovine brain microvascular endothelial cells (BBMEC). Within a few hours of incubation with pneumococci, rounding and detachment of the HBMEC were observed, and the transendothelial electrical resistance of the BBMEC monolayer decreased markedly. An S. pneumoniae mutant deficient in pneumolysin did not affect the integrity of the endothelial cell monolayer. Neither cell wall fragments nor isolated pneumococcal cell walls induced changes of endothelial cell morphology. However, purified pneumolysin caused endothelial cell damage comparable to that caused by the viable pneumococci. The cell detachment was dependent on de novo protein synthesis and required the activities of caspase and tyrosine kinases. The results show that pneumolysin is an important component for damaging the BBB and may contribute to the entry of pneumococci into the cerebral compartment and to the development of brain edema in pneumococcal meningitis.
Methods to Monitor and Control Scale in Cooling Water Systems (2001)

Abstract This paper describes two novel methods to monitor the activity of scale control programs used for treatment of open recirculating cooling water systems. The first technique is a reagent based at-line colorimetric method that provides a fundamental understanding of the treatment program performance. Also detailed is a reagentless, on-line flurometric method that directly determines program performance and allows advanced control strategies of both the treatment program and system operation. Evidence is shown that the loss or consumption of the polymer is a sensitive measure of the scaling tendency of a cooling water system. Finally, the use and benefits of polymer consumption to control a cooling system to save water and minimize scale under upset conditions is demonstrated.
The impact of brannerite on the release of plutonium and gadolinium during the corrosion of zirconolite-rich titanate ceramics (2000)

Titanate ceramics have been selected as the preferred waste form for the immobilization of excess plutonium. Corrosion tests are underway to try to understand the long-term behavior of this material. In this paper, results from PCT-B static dissolution tests are used to provide an explanation of the observed corrosion behavior of a zirconolite-based ceramic. Two important observations are made. First, Ca is released at a constant rate [7 x 10{sup {minus}5} g/(m{sup 2} day)] in PCT-B tests for up to two years. Second, the release rates for Pu and Gd increase with time (up to two years) in PCT-B tests. The first observation suggests that the ceramics continue to corrode at a low rate for at least two years in PCT-B tests. The second observation suggests that the release rates of Pu and Gd are controlled by some process or processes that do not affect the release rate of other elements. Evidence indicates that this is due to the preferential dissolution of brannerite from the ceramic.
Gas chromatography based on Micro Electro Mechanical Systems (MEMS) (2018)

International audience
Glutathione transferase of human breast is closely related to transferase of human placenta and erythrocytes. (1986)

An acidic form (pI 4.6) of glutathione transferase has been purified to homogeneity from normal and tumor specimens of human breast. The two proteins did not differ significantly in their molecular and catalytic properties. The enzyme has a molecular weight of 46,000 and is composed of two identical subunits. The data presented, including amino acid composition, substrate specificity and immunological studies, give strong evidence that the glutathione transferase of human breast, placenta and erythrocytes are similar if not identical proteins.
Ligand-based control of nuclearity in (NHC)gold(i) sulfides (2021)

N-Heterocyclic carbene (NHC) ligands support gold(I) sulfide complexes of varying nuclearity and charge. For sterically undemanding ligands, gold(I) chlorides react with sulfide to form trigold μ<sub>3</sub>-sulfido cations as the first observed products. The ligand IMes [1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene] supports a monomeric cation, whereas the ICy-(1,3-dicyclohexylimidazol-2-ylidene-) supported cation crystallises as a dimer linked through an aurophilic interaction. The more sterically demanding IDipp [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene] supports a terminal hydrosulfide, a (μ-hydrosulfido)digold cation, and a μ<sub>3</sub>-sulfido cation. Use of the expanded-ring NHC 7Dipp [1,3-bis(2,6-diisopropylphenyl)-4,5,6,7-tetrahydro-1,3-diazepin-2-ylidene] allows the isolation of a neutral digold sulfide.
Twenty-four hour patterns of prolactin secretion during lactation and the relationship to suckling and the resumption of fertility hi breast-feeding women (1996)

In breast-feeding women prolactin released in response to suckling is essential for the maintenance of lactation. This physiological hyperprolactinaemia is also associated with lactational infertility. However, it is not clear whether there is any direct relationship between changes in prolactin per se and the duration of infertility. To address this question, our study determined the pattern of prolactin secretion in relation to suckling and the return of ovarian activity in the same cohort of breast-feeding women. Blood samples were withdrawn at 10 min intervals for 24 h from 09:00 to 09:00 h at either 4 (n = 9) or 8 weeks (n = 11) post-partum when the women had completely suppressed ovarian activity, at the time of the introduction of supplements to the baby (n = 17), a time associated with reduction of suckling activity, at first menses while still breast-feeding (n = 13) and in the follicular phase (n = 9) of the first menstrual cycle after weaning. During sampling, mothers and babies continued their normal pattern of suckling activity. The pattern of prolactin release was very variable at each stage of lactation, depending on the pattern of suckling. Frequent suckling was associated with elevated prolactin concentrations during the 24 h period throughout lactation. When suckling was less frequent, prolactin concentrations fell to baseline values between breast-feeds, but prolactin was released in response to all suckling episodes. An increase in prolactin concentrations at night, independent of suckling, was only evident once breast-feeding had ceased. The prolactin response to suckling declined significantly only after the return of menses at 33.6 +/- 3.5 weeks post-partum. There was no relationship between the duration of amenorrhoea and the plasma concentrations of prolactin over 24 h, or day or night separately, throughout lactation. However, there was a strong correlation (r = 0.843; P < 0.01) between the timing of the introduction of dietary supplements to the baby and the duration of amenorrhoea. These results suggest that there may be no precise link between the release of prolactin during lactation and the duration of lactational infertility in breast-feeding women.
Web-enabled Customer-oriented Product Concept Formation via Laddering Technique and Kohonen Association (2002)

Product concept formation is regarded as a key activity in new product development and manufacturing (NPD&amp;M). It may determine whether a NPD&amp;M project will be successful or not. In the early stage of product concept formation, owing to the huge space of possible solutions as well as incomplete and imprecise information, it is difficult for designers to generate functional attributes and subsequently select customer-preferred design solutions. Although much research has been attempted to tackle this problem, few of them are capable of appropriately making a trade-off between initial design requirements of designers and those of customers. This study aims at establishing a prototype web-based customer-oriented product concept formation system. The prototype system involves customers in generating functional attributes and design alternatives as well as selecting preferred design solutions. To realize these, the laddering technique is first employed to set up a so-called functional attribute hierarchy (FAH) comprising different levels ranging from generic to specific abstraction. With the FAH established, diverse design alternatives can then be configured morphologically using a combination of alternative values. Consequently, through customer interaction via the web, the Kohonen association algorithm is utilized to facilitate the selection of preferred design alternatives according to multicultural customer groups. The details of the prototype system as well as a case study on wood golf club design, which is used to illustrate its capability, are presented in this paper.
Moving toward whole-genome analysis: A technology perspective (2005)

New technology enables efficient, large-scale analysis of the whole genome, genetic variations, and gene expression. Genomic analysis has profound clinical, economic, and social implications for health care.
Reference and Representation (1996)

this paper was supported by the Royal Netherlands Academy of Arts and Sciences (KNAW), and by the ESPRIT basic research project DYANA. For their stimulating ideas I am glad I can thank Irene Heim, Hans Kamp, Fred Landman and Ede Zimmermann, besides, of course, Jeroen Groenendijk, Martin Stokhof and Frank Veltman. The dynamic turn taken with these last-mentioned systems of interpretation raises a number of theoretical questions. In the first place there is the question to what extent old-fashioned concepts of static semantic systems can be retained, or may have to be re-assessed when interpretation and meaning merge. For instance, although DRT does employ familiar concepts of satisfaction and truth for its language of DRSs, it is not clear from the outset how these concepts apply to the
ChemInform Abstract: PREPARATION AND PROPERTIES OF SOME HYDROCORPHINOID NICKEL(II) COMPLEXES (1982)

Abstract Die Umsetzung des Ni(II)‐corphinat‐Komplexes (I) mit Zn in AcOH/MeOH führt zu dem 18,19‐Dihydro‐Komplex (II).
Small signal model extraction procedure for RF SoS MOSFETs (2006)

Silicon on Sapphire technology holds significant promise for the implementation of millimeter wave and radio frequency systems and circuits. Circuits built using this technology have higher linearity. The sapphire insulating substrate allows for very tow coupling between circuit components and the realization of higher quality factor inductors due to reduced induced eddy currents in the substrate, Unfortunately many foundry process development kits do not support millimeter wave frequency design. The extraction procedures successful at lower frequencies for lumped circuit extraction are prone to failure at higher frequencies. This paper proposes a multi-step extraction procedure that is shown to accurately extract model parameters at higher frequencies. The contributions of this paper are: 1) A small signal model extraction procedure that permits accurate extraction of parameters at millimeters wave frequencies. 2) A small signal equivalent millimeter wave frequency model for Silicon on Saphire (SOS).
ChemInform Abstract: Molecular Structure and Smectic Properties: The Substituent Effect on the Smectic A Phase in Biphenyl Ester Systems (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fully Integrated Differential Distributed VCO in 0.35-$\mu{\hbox {m}}$ SiGe BiCMOS Technology (2007)

We present a fully integrated differential distributed voltage-controlled oscillator implemented in a 0.35-mum SiGe BiCMOS technology. The delay variation by a positive feedback tuning technique, adopted from the ring oscillators, is demonstrated as a fine-tuning alternative, which results to an approximately 420-MHz tuning range. The phase noise is -98 dBc/Hz at 1-MHz offset from the 14.25-GHz carrier. An integrated output buffer isolates the oscillator from the measurement equipment. The measured output power is -17.5 dBm and the overall power consumption of the chip is 138.1 mW employing two power supplies of 3.2 and 4.2 V, respectively
Preparation of 1, 3‐dioleoyl‐2‐palmitoylglycerol‐rich structured lipids from basa catfish oil: Combination of fractionation and enzymatic acidolysis (2015)

1,3‐dioleoyl‐2‐palmitoylglycerol (OPO)‐rich structured lipids were successfully prepared from basa catfish oil by a two‐step process, namely, fractionation to enrich triacylglycerol (TAG) fractions with high content of sn‐2 palmitic acid and Lipozyme RM IM‐catalyzed acidolysis of the fractionated products with free fatty acids from high oleic acid sunflower oil to increase the content of OPO. In the first step, the content of sn‐2 palmitic acid of solid fraction was increased from 49.34 to 60.42% after programmed temperature treatment of basa catfish oil at 60°C for 30 min followed by 30°C for 12 h. In the second step, the solid fraction was used for transesterification with the fatty acids from high oleic acid sunflower oil and the conditions selected for acidolysis reactions were as follows: substrate molar ratio, 1:6 (fatty acids/solid fat); enzyme load, 12 wt%; reaction temperature, 50°C; and reaction time, 2 h. Under these conditions, the contents of sn‐2 plamitic acid and sn‐1, 3 oleic acid were 57.80 and 79.21%, respectively, and the content of POO was increased from 20.13% in the basa catfish oil to 43.80% in the enzymatic product, which indicated high content of OPO. Practical applications: Basa catfish oil is a type of newly discovered oil occurring in nature with similar fatty acid composition and distribution to human milk fat. Preparation of OPO‐rich structured lipids from basa catfish oil is a new method which is important for development of human milk fat substitutes. This process for OPO‐rich structured lipid preparation practically developed by combination of dry fractionation and enzymatic acidolysis has great potential for use in infant formula industry. Basa catfish oil was found to have similar triacylglycerol (TAG) structure to that of human milk fat. The oil was used to produce OPO‐rich structured lipids via a two‐step approach. The first step is to enrich TAG fractions with palmitic acid (PA) at sn‐2 position by low‐temperature fractionation, and the second step is to incorporate more oleic acid (OA) in sn‐1, 3 positions of triacylglycerols by Lipozyme RM IM‐catalyzed acidolysis. The final product had 22.29% total PA, 58.43% PA at sn‐2 position, 80.16% OA at sn‐1, 3 positions, and the content of POO was 43.80%, which indicated high content of OPO.
The Autographa californica Baculovirus Genome: Evidence for Multiple Replication Origins (1992)

The Autographa californica multinucleocapsid nuclear polyhedrosis virus (AcMNPV), which is used for the overexpression of eukaryotic genes and is being engineered for possible use as a viral insecticide, has a circular, supercoiled genome of approximately 128 kilobases. Despite its widespread use, little is known about the mechanism by which AcMNPV replicates. Evidence is presented in this report that AcMNPV origins of DNA replication are repeated sequences each containing several closely related imperfect palindromes that are present in six regions distributed around the genome. Although AcMNPV infection-dependent plasmid replication was initiated by a single complete palindrome, the amount of replication was substantially increased in plasmids containing six or eight palindromes.
Compressed Sensing for Thoracic MRI with Partial Random Circulant Matrices (2012)

The use of Circulant matrix as the sensing matrix in compressed sensing (CS) scheme has recently been proposed to overcome the limitation of random or partial Fourier matrices. Aside from reducing computational complexity, the use of circulant matrix for MR image offers the feasibility in hardware implementations. This paper presents the simulation of compressed sensing for thoracic MR imaging with circulant matrix as the sensing matrix. The comparisons of reconstruction of three different type MR images using circulant matrix are investigated in term of number of samples, number of iteration and signal to noise ratio (SNR). The simulation results showed that Circulant Matrix works efficiently for encoding the MR image of respiratory organ, especially for smooth and sparse image in spatial domain.
Polycystic Kidney Disease (2015)

Polycystic kidney disease (PKD) is characterized by the presence of fluid-filled cysts in the kidneys. It is the fourth most common cause of chronic renal insufficiency or end-stage kidney disease. This book focuses on the basic and clinical aspects of the burgeoning PKD research under three sections. Section 1 provides a comprehensive guide to the diagnosis, management and treatment of PKD. Section 2 covers most of the fundamental molecular and cellular mechanisms underlying PKD, and how this knowledge is contributing to the development of potential novel therapeutic agents. Finally, section 3 focuses on extra-renal or secondary complications of PKD. Number of chapters 20; Contributors: 48; Figures: 42; Tables: 12; Pages: 488.
Electronic version is freely available. Hardcover copies are available at books@codonpublications.com
Animal Welfare as a Design Goal in Technology Mediated Human-Animal Interaction (2014)

Designing technology mediated human-animal interaction with the animal welfare as a design goal calls for understanding of animal welfare issues. This paper discusses the notion of animal welfare and specifically focuses on domestic dogs (canis familiaris) as an example case. Strategies for mediating relatedness are discussed and an initial framework to support designing tactile interactions for human-animal interaction is presented. Paper builds its reasoning upon scientific research on human-animal interaction and welfare, and identifies issues for future work in this area.
Cyclophosphamide mechanism of action in preclinical tecemotide studies (2013)

Meeting abstracts Tecemotide is a MUC1 antigen-specific therapeutic cancer vaccine. In phase III clinical studies, delivery of tecemotide is preceded by a single low dose of cyclophosphamide (CPA) to inhibit regulatory T cells (Tregs) and enhance the response to the tumor-associated antigen. Here,
Error propagation and the achievable throughput-delay trade-off in wireless networks (2011)

New results on the achievable trade-off between the per-node throughput T(n) and the average delay D(n) in a static wireless network of n nodes are presented for physical link models. For links modeled by channels with additive white Gaussian noise with power-law attenuation, a trade-off of only D(n) = ⊖ (n (log n) T(n)) is guaranteed for T(n) = ⊖(n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-½</sup> ). This follows from showing that there is significant information loss in the network due to error propagation, unless the length of the channel code employed is sufficiently high. Constraining the block length to be bounded yields worse trade-offs: only ⊖(n (log n) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> T(n)) is guaranteed for optimal throughput, provided there is rich fading diversity.
Designing Primers for Whole Genome PCR Scanning Using the Software Package GenoFrag (2007)

Whole-genome polymerase chain reaction (PCR) scanning (WGPS) is based on the PCR amplification of small-sized chromosomes (e.g., bacterial chromosomes) by long-range PCR with a set of primers designed using a reference strain and applied to amplify several other strains. Such an approach of genome variability has specific requirements for the selection of primers and the design of primer pairs for the optimal coverage of the chromosome. To facilitate such analysis, we have developed GenoFrag, a software package for the design of primers optimized for whole-genome scanning by long-range PCR. GenoFrag works in a two-step procedure: first, a list of primers is selected according to the basic criteria, and second, the list of primer candidates is used for the coverage of the whole chromosome. These two steps are presented here with a part of the algorithm scripts developed for this software. Examples of what can be done using GenoFrag are illustrated by results obtained from the online version of the software. GenoFrag has already been validated in long-range (LR)-PCR experiment on several bacterial species. It is a robust and reliable tool for primer design for WGPS.
Ectopic expression of the PISTILLATA homologous MdPI inhibits fruit tissue growth and changes fruit shape in apple (2018)

Fruit shape represents a key trait that consumers use to identify and select preferred cultivars, and although the manipulation of this trait is an opportunity to create novel, differentiated products, the molecular mechanisms regulating fruit shape are poorly understood in tree fruits. In this study, we have shown that ectopic expression of <i>Malus domestica PISTILLATA (MdPI),</i> the apple ortholog of the floral organ identity gene <i>PISTILLATA (PI),</i> regulates apple fruit tissue growth and shape. <i>MdPI</i> is a single-copy gene, and its expression is high during flower development but barely detectable soon after pollination. Transgenic apple plants with ectopic expression of <i>MdPI</i> produced flowers with white sepals and a conversion of sepals to petals. Interestingly, these plants produced distinctly flattened fruit as a consequence of reduced cell growth at the basipetal position of the fruit. These altered sepal and fruit phenotypes have not been observed in studies using <i>Arabidopsis</i>. This study using apple has advanced our understanding of PI functions outside the control of petal and stamen identity and provided molecular genetic information useful for manipulating fruit tissue growth and fruit shape.
Diagnostic performance of the ARCHITECT C-Peptide immunoassay (2009)

The ARCHITECT C-Peptide assay measures C-peptide rapidly, accurately, and precisely in human serum, plasma and urine. It provides useful improvements for beta-cell function testing and for evaluating the clinical status of a patient in combination with other diabetes markers.