gebhart/patrepeval huggingface dataset:
Assessing the Impact of Denitrifier-Produced Nitric Oxide on Other Bacteria (2006)

A series of experiments was undertaken to learn more about the impact on other bacteria of nitric oxide (NO) produced during denitrification. The denitrifier Rhodobacter sphaeroides 2.4.3 was chosen as a denitrifier for these experiments. To learn more about NO production by this bacterium, NO levels during denitrification were measured by using differential mass spectrometry. This revealed that NO levels produced during nitrate respiration by this bacterium were in the low muM range. This concentration of NO is higher than that previously measured in denitrifiers, including Achromobacter cycloclastes and Paracoccus denitrificans. Therefore, both 2.4.3 and A. cycloclastes were used in this work to compare the effects of various NO levels on nondenitrifying bacteria. By use of bacterial overlays, it was found that the NO generated by A. cycloclastes and 2.4.3 cells during denitrification inhibited the growth of both Bacillus subtilis and R. sphaeroides 2.4.1 but that R. sphaeroides 2.4.3 caused larger zones of inhibition in the overlays than A. cycloclastes. Both R. sphaeroides 2.4.3 and A. cycloclastes induced the expression of the NO stress response gene hmp in B. subtilis. Taken together, these results indicate that there is variability in the NO concentrations produced by denitrifiers, but, irrespective of the NO levels produced, microbes in the surrounding environment were responsive to the NO produced during denitrification.
Frontispiece: Molecular Flytraps Held Together by Platinum–Platinum Intermetallic Bonds (2023)

Supramolecular Chemistry. In their Communication (e202305525), Mark J. MacLachlan use a single Pt−Pt bond to glue two cyclometalated hosts together and generate a flytrap-like molecule. This compound traps inorganic ions, assembles and disassembles photochemically, and irreversibly transports guests from solution to the solid state.
A Simple and Efficient Quasi-3D Magnetic Equivalent Circuit for Surface Axial Flux Permanent Magnet Synchronous Machines (2018)

This paper presents a simple and efficient magnetic equivalent circuit (MEC) model for surface axial flux permanent magnet synchronous machines. The MEC model is used to solve all the electromagnetic properties of the machine including the no load, full load voltages, cogging torque, torque ripple, and stator iron core losses. Moreover, this approach can be extended for all surface permanent magnet synchronous machines. The main novelty of this approach is the development of a static system, which accounts for the rotation. The model takes into account the rotor rotation via time-dependent permanent magnet magnetization sources. The static system matrix facilitates a very fast solving. In addition, to take into account the three-dimensional (3-D) effect, a multislicing of the machine in the radial direction is done. This boosts the simulation time to only 60 s for six slices and 50 time steps including the nonlinear behavior of the stator elements with a great accuracy. Additionally, the number of elements in the MEC can be adjusted to reduce the computational time. This model is verified by means of 3-D and two-dimensional (2-D) multislice finite-element models. In addition, experimental validations are also provided at the end.
Tai Chi and Pulmonary Rehabilitation Compared for Treatment-Naive Patients With COPD (2018)

ClinicalTrials.gov; No.: NCT02665130; URL: www.clinicaltrials.gov.
ChemInform Abstract: SYNTHESIS OF DL‐SEPTICINE (1980)

Abstract Die Cycloadditionsreaktion von Pyrrolin‐N‐oxid (I) mit dem Bis‐(dimethoxyphenyl)‐butadien (II) liefert zwei stereoisomere Addukte (III) und (IV), von denen (III) bei der Umsetzung mit Zink/Eisessig jedoch nicht zu dem erwarteten Ringschluß führt, sondern (V) ergibt.
Activity of aspirin analogues and vanillin in a human colorectal cancer cell line (2011)

Colorectal cancer is the third most common cancer and is associated with significant morbidity and mortality. Epidemiological and animal studies indicate that regular acetylsalicylic acid (aspirin) intake is associated with a reduction in the incidence of colorectal cancer. Acetylsalicylic acid (ASA) has also been shown to inhibit colorectal cancer cell proliferation in vitro. The molecular basis for this specific cytotoxicity is an area of considerable debate. To investigate the toxicity of salicylates, the sensitivity of the DNA mismatch repair proficient SW480 human colorectal cancer cell line to four categories of compounds with varying degrees of structural similarity to acetylsalicylic acid was tested. These compounds were: i) salicylic acid analogues with substituents at the 5-position; ii) ASA analogues with extended chain lengths in the acyl group; iii) vanillin (4-hydroxy-3-methoxybenzaldehyde; and iv) bis(2-carboxyphenyl) succinate (BCS) and structurally similar derivatives thereof. It was found that compounds with amino and acetamido substituents at the salicylate 5-position were less toxic than ASA itself. Modifications to the length of the hydrocarbon chain in the acyl groups of ASA analogues also marginally reduced toxicity. Vanillin exhibited relatively limited toxicity against the SW480 colorectal cancer cell line. Commercially available and in-house synthesised BCS (diaspirin) were notably more inhibitory to cell growth than ASA itself, yet retained substantial specificity against colorectal cancer cell lines vs. non-colorectal cancer cell lines. BCS and ASA were toxic to SW480 cells through initiation of necrotic and apoptotic pathways. Fumaroyldiaspirin and benzoylaspirin exhibited greater toxicity than ASA against the SW480 cell line. A novel method for synthesis of BCS, a compound that has erratic commercial availability, is described. We propose that the anti-inflammatory and anticancer capacity of BCS and the other analogues described herein is worthy of investigation.
Cyclic Dimethylsiloxanes as Pseudo Crown Ethers: Syntheses and Characterization of Li(Me2SiO)5[Al{OC(CF3)3}4], Li(Me2SiO)6[Al{OC(CF3)3}4], and Li(Me2SiO)6[Al{OC(CF3)2Ph}4] (2006)

An unexpected guest: The salts LiD5[AlF], LiD6[AlF], and LiD6[AlPhF] (Dn=(Me2SiO)n; [AlF]=Al{OC(CF3)3}4; [AlPhF]=Al{OC(CF3)2Ph}4) are the first host–guest complexes to be synthesized directly from cyclic dimethylsiloxanes, alkali-metal ions, and weakly coordinating anions. Their experimental and calculated structures imply that the cyclic dimethylsiloxanes act as pseudo crown ethers (see structure of [LiD6]+).
Physicochemical properties of surfaces of SBA-15 silicas, according to adsorption-static, gas-chromatographic, and IR spectroscopic data (2015)

Interaction between vapors of organic compounds and water with surfaces of mesoporous silica SBA-15 and silica SBA-15 modified with n-C6F13(CH2)2Si(CH3)2Cl via adsorption under static conditions is studied by means of gas chromatography and IR diffuse reflectance spectroscopy. It is shown that modification notably reduces the energy of disperse and specific interactions, along with the acidity of adsorption centers. Even low concentrations of the grafted groups (0.76 nm–2) allows us to obtain highly hydrophobic coatings on SBA-15 surfaces.
Sensor-Actuated Roboduck Network for Marine Monitoring (2005)

Author(s): Amit Dhariwal; Gaurav S. Sukhatme; Aristides A.G. Requicha; David Caron; Carl Oberg; Beth Stauffer; Eric Shieh
The Influence of Exocyclic Stereochemistry on the Tethered Aminohydroxylation Reaction (2011)

A new strategy that employs an exocyclic stereocenter to effect diastereocontrol in the tethered aminohydroxylation (TA) reaction is applied to the stereoselective synthesis of a range of amino alcohols in good to excellent yields, and with anti selectivities of up to 20:1. The influence of the reaction conditions and substrate parameters on the level of diastereocontrol is described. Furthermore, an "inside alkoxy" model is employed to rationalize the sense and degree of stereoselectivity observed in these systems.
Calculation of Primary Aberrations: Perturbed Optical Systems (2009)

7.1 INTRODUCTION The image quality of an optical system is limited not only by its inherent design aberrations, discussed in Chapters 5 and 6 for rotationally symmetric systems, but also by the fabrication and assembly errors of its elements. New aberrations arise when its elements are misaligned with respect to each other owing to lack of the rotational symmetry of the resulting perturbed system. The misalignment of an element may be the decentering of its vertex and/or tilting of its optical axis. The decenter of an element usually refers to a misposition of its vertex in a plane normal to its intended optical axis. The decenter along its optical axis is usually called despace in that the spacing between it and its adjacent element is incorrect. It should be evident that when one or more elements of a system are decentered or tilted, it loses its rotational symmetry since it no longer has a common optical axis. However, when the elements are only despaced, the system retains its common optical axis and, therefore, its rotational symmetry. In this chapter, we discuss how to determine the primary aberrations of a perturbed optical system assuming that they are known for the unperturbed system. The first-order effect of a decenter or a tilt of a surface of a system is to produce a transverse displacement of the image formed by the unperturbed system. Its second-order effect is to introduce some new aberrations. It is shown that a small decenter or a tilt does not change the primary spherical aberration of a system. However, if the spherical aberration of the unperturbed system is not zero, it introduces coma that is independent of the image height but depends on the pupil coordinates in the same manner as the primary coma. Since it exists for an on-axis point object, it is called axial coma. The other primary aberrations generate aberrations in addition to their own kind in pupil coordinates. For example, coma of the unperturbed system produces coma, astigmatism, and field curvature when it is perturbed. The degree of a new aberration in the image height is one less than the degree of the corresponding aberration of the unperturbed system. Thus, the additional coma is independent of the image height, astigmatism varies linearly with it, and distortion varies quadratically. A despace error displaces the image and the exit pupil (unless it is also the aperture stop) longitudinally and changes the values of the image distance and the distance of the image from the exit pupil. Accordingly, it changes the value of the aberrations introduced by the despaced element. In a multisurface system, the positions of the image and exit pupil change for each surface that follows the despaced surface. The change in the aberrations introduced by each surface can be calculated in a similar manner. The general equations for the aberrations introduced by a misaligned surface are derived and the results are applied to two-mirror telescopes discussed in Section 6.8.
In vitro models of collagen biomineralization (2013)

Over the last several years, significant progress has been made toward understanding the mechanisms involved in the mineralization of hard collagenous tissues, such as bone and dentin. Particularly notable are the identification of transient mineral phases that are precursors to carbonated hydroxyapatite, the identification and characterization of non-collagenous proteins that are involved in controlling mineralization, and significant improvements in our understanding of the structure of collagen. These advances not only represent a paradigm shift in the way collagen mineralization is viewed and understood, but have also brought new challenges to light. In this review, we discuss how recent in vitro models have addressed critical questions regarding the role of the non-collagenous proteins in controlling mineralization, the nature of the interactions between amorphous calcium phosphate and collagen during the early stages of mineralization, and the role of collagen in the mineralization process. We discuss the significance of these findings in expanding our understanding of collagen biomineralization, while addressing some of the limitations that are inherent to in vitro systems.
Reduction of relapses of atopic dermatitis with methylprednisolone aceponate cream twice weekly in addition to maintenance treatment with emollient: a multicentre, randomized, double-blind, controlled study (2008)

MPA twice weekly plus an emollient provides an effective maintenance treatment regimen to control AD. Once stabilized, treatment with MPA significantly reduces the risk of relapse and the intensity of itching, and improves the overall patient status.
Cardiac Toxicity Associated with the Anti-VEGF Monoclonal Antibody Bevacizumab (Avastin) in Combination with CHOP (A-CHOP) Chemotherapy for Peripheral T Cell Lymphoma (PTCL): The ECOG 2404 Trial. (2009)

Abstract Abstract 1671 Poster Board I-697 Background Bevacizumab (Avastin), a humanized monoclonal antibody directed against vascular endothelial growth factor (VEGF-A), is approved in combination with chemotherapy in lung, colorectal, breast and brain cancers. VEGF-A expression is reported in all lymphoma subtypes, with strongest expression in PTCL. Given the relatively poor prognosis of PTCL with standard therapy, we combined bevacizumab (A) with CHOP in the ECOG 2404 phase II trial. Methods Untreated PTCL pts with a normal baseline cardiac ejection fraction received bevacizumab 15 mg/ kg IV and CHOP chemotherapy on day 1 for 6-8 cycles. Patients (pts) with CR/PR/SD received maintenance therapy with bevacizumab 15 mg/ kg IV q 3 weeks for 4 cycles. Due to the reported 3.7% incidence of cardiac toxicity associated with bevacizumab in metastatic breast cancer pt previously exposed to anthracyclines (Avastin package insert), cardiac function was monitored prospectively with ejection fraction (EF) determination at the completion of A-CHOP prior to the start of bevacizumab maintenance. Results Among 33 pts who came off study, toxicity data are available for all and coded using CTCAE Version 3.0. 22 received at least 4 cycles of A-CHOP (median treatment duration 3.6 months (&lt; 1-10.6 months). One or more designated cardiac toxicities were recorded for 5 of these 22 pts. Congestive heart failure (CHF), defined as grade 2-4 left ventricular dysfunction was recorded in 4 pt (18%, 90% CI 5.2%-40.3%): grade 4 (n=1), grade 3 (n=3). In 3 pts clinical CHF occurred after A-CHOP x 6 and in one during bevacizumab maintenance after A-CHOP x 8. The median time to development of a cardiac adverse event was 5 months (3.5 – 8.8 months). One pt required a ventricular assist device in addition to medical management. In 3 of the 4 pts, ongoing medical management for CHF has been required. Other cardiac toxicities included ventricular arrhthymia (one grade 4, one grade 2), and one grade 2 cardiac troponin elevation. In addition, one patient experienced sudden death of uncertain cause. Three pts developed thromboses or embolic toxcities (two grade 4 and one grade 3). Conclusions We observed four cases of clinical CHF early after cumulative doxorubicin doses of 300-400 mg/m2 in our study, The incidence of CHF among study patients who received 4 or more A-CHOP cycles is concerning and suggests that bevacizumab may potentiate the adverse cardiac effects of anthracyclines, resulting in clinically significant toxicity. Careful monitoring of cardiac function is warranted in ongoing trials combining bevacizumab and doxorubicin in lymphomas and solid tumors to assess long-term safety and better understand underlying mechanisms and risks. Disclosures No relevant conflicts of interest to declare.
Préparation de nanothermites réactives désensibilisées (2022)

Safer handling of sensitive energetic materials is the main concern of nanothermites development. These compositions, made from a metal oxide and a metallic fuel, show interesting reactive properties but also an extreme sensitivity to electrostatic discharge leading to make their handling hazardous. The aim of the thesis is to purpose safer and reactive nanothermites by additive’s adding. Due to their high electrical conductivities, the conducting polymers, polyaniline and polypyrrole, were chosen to rapidly dissipate the charges through the medium and so delay the ignition of nanothermite (raise of sensitivity threshold). These additives are added with a powdered way within the nanothermite and then as a composite with the oxide or with the oxide and aluminium. Depending on the way of polymers’ introduction, its morphology or mass content, different nanothermites could be obtained with various sensitivity and reactive properties. Thus, the oxide-polymer structuration enables a raise of sensitivity threshold, with a small amount of polymer, while keeping an acceptable reactivity.
An overview of the crash dynamics failure behavior of metal and composite aircraft structures (1991)

An overview of failure behavior results is presented from some of the crash dynamics research conducted with concepts of aircraft elements and substructure not necessarily designed or optimized for energy absorption or crash loading considerations. Experimental and analytical data are presented that indicate some general trends in the failure behavior of a class of composite structures that includes fuselage panels, individual fuselage sections, fuselage frames, skeleton subfloors with stringers and floor beams without skin covering, and subfloors with skin added to the frame stringer structure. Although the behavior is complex, a strong similarity in the static/dynamic failure behavior among these structures is illustrated through photographs of the experimental results and through analytical data of generic composite structural models.
Highly Oriented Growth of Catalytically Active Zeolite ZSM‐5 Films with a Broad Range of Si/Al Ratios (2017)

Highly b-oriented zeolite ZSM-5 films are critical for applications in catalysis and separations and may serve as models to study diffusion and catalytic properties in single zeolite channels. However, the introduction of catalytically active Al<sup>3+</sup> usually disrupts the orientation of zeolite films. Herein, using structure-directing agents with hydroxy groups, we demonstrate a new method to prepare highly b-oriented zeolite ZSM-5 films with a broad range of Si/Al ratios (Si/Al=45 to ∞). Fluorescence micro-(spectro)scopy was used to monitor misoriented microstructures, which are invisible to X-ray diffraction, and show Al<sup>3+</sup> framework incorporation and illustrate the differences between misoriented and b-oriented films. The methanol-to-hydrocarbons process was studied by operando UV/Vis diffuse reflectance micro-spectroscopy with on-line mass spectrometry, showing that the b-oriented zeolite ZSM-5 films are active and stable under realistic process conditions.
Supplementary Figure 1B from CIP2A Modulates Cell-Cycle Progression in Human Cancer Cells by Regulating the Stability and Activity of Plk1 (2023)

&lt;p&gt;PDF file, 962K, Immunohistochemical analysis of CIP2A and Plk1 expression in various human cancer specimens.&lt;/p&gt;
Empirical Mode Decomposition-Based DC Measurement for Photovoltaic Power Generation System (2022)

Due to the advantages such as being clean and safe, photovoltaic (PV) power generation has become an emerging industry of widespread concern in the world. However, the connection of PV inverters and the unknowability of environmental factors cause effective operation status information submerged in interference. To this end, this paper proposes a PV-DC signal de- noising method based on empirical mode decomposition (EMD) combined with wavelet adaptive threshold. The frequency-domain waveform characteristics of different operating conditions are investigated by analyzing theoretical model and fault recording data. The fast Fourier transform (FFT) based on Hanning window is used to extract the frequency-domain features. Extensive test results using simulation data demonstrate the feasibility of the proposed method.
Heterologous Protein Production from the Inducible MET25 Promoter in Saccharomyces cerevisiae (2005)

Heterologous protein production late in Saccharomyces cerevisiae fermentations is often desirable because it may help avoid the unintentional selection of more rapidly growing, non-protein-expressing cells or allow for the expression of toxic proteins. Here, we describe the use of the MET25 promoter for the production of human serum albumin (HSA) and HSA-fusion proteins in S. cerevisiae. In media lacking methionine, the MET25 promoter yielded high expression levels of HSA and HSA fused to human glucagon, human growth hormone, human interferon alpha, and human interleukin-2. More importantly, we have shown that this system can be used to delay heterologous protein production until late log phase of the growth of the culture and does not require the addition of an exogenous inducer.
Islet Encapsulation Using Chondrocyte (2014)

Diabetes mellitus is one of the leading metabolic diseases that cause an increasing rate of mortality and morbidity. Recently, rather than the current drug treatment, pancreatic islet transplantation has been regarded as a potentially promising strategy for insulin-dependent diabetes mellitus while preventing complications such as kidney damage, vascular damage, nerve damage, and blindness. Recently, a number of advanced islet encapsulation techniques have been designed to enhance the efficiency of islet transplantation, including cell sheet engineering and generation of 3D islet spheroids by high density suspension system (HDSS).
High resolution techniques for the fabrication of small area Josephson tunnel junctions (1981)

Superconducting tunnel junction devices as small as 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-10</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> have been made using novel self-aligning techniques in conjunction with optical or e-beam lithography. This process has been used to fabricate complete circuits and multijunction arrays under well controlled conditions, using a single resist patterning step.
Short-Wavelength Spin-Wave Transducer Using the Transmission of Spin-Waves Across Two Magnetic Films (2023)

There has been growing interest in using spin waves as an alternative information carrier or state variable. One proposed use of spin waves is to utilize the diffraction and interference of spin waves to perform highly parallelized computing of specific functions. This new class of devices would require isotropic dispersion relations. The subject of this work is a transducer designed to convert electrical signals into short-wavelength forward-volume spin waves. Short-wavelength spin waves would enable spin-wave devices to scale down to smaller sizes and potentially allow the use of films that are CMOS compatible but suffer from higher damping. This work presents a new design of electrical-to-spin-wave transducers that can excite short-wavelength spin waves by first exciting large-wavelength (<inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$1.43~\mu \text{m}$ </tex-math></inline-formula> for example) spin waves using relatively large coplanar waveguides (CPWs). The spin waves are then transformed into short-wavelength (132 nm) spin waves by traveling into an adjacent film where their wavelengths decrease significantly. Simulations show that this design is able to excite spin waves with significantly larger amplitudes (<inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$10\times $ </tex-math></inline-formula>) than an appropriately sized CPW on top of the magnetic film with the same input power.