gebhart/patrepeval huggingface dataset:
N‐Linked Glycans of Chloroviruses Sharing a Core Architecture without Precedent (2015)

Abstract N‐glycosylation is a fundamental modification of proteins and exists in the three domains of life and in some viruses, including the chloroviruses, for which a new type of core N‐glycan is herein described. This N‐glycan core structure, common to all chloroviruses, is a pentasaccharide with a β‐glucose linked to an asparagine residue which is not located in the typical sequon N‐X‐T/S. The glucose is linked to a terminal xylose unit and a hyperbranched fucose, which is in turn substituted with a terminal galactose and a second xylose residue. The third position of the fucose unit is always linked to a rhamnose, which is a semiconserved element because its absolute configuration is virus‐dependent. Additional decorations occur on this core N‐glycan and represent a molecular signature for each chlorovirus.
Mixed conducting ceramic membranes for gas separation and reaction (1999)

The development of dense ceramic membranes for separating and reacting various gaseous components has been under intense investigation during the past several years. Such applications include the separation of oxygen from air, the partial oxidation of methane and other hydrocarbons, and the separation of hydrogen from synthesis gas or other hydrogen-containing process streams. The US Department of Energy is currently sponsoring major efforts in the development of these membranes for advanced power and fuels production applications. This article provides an overview of the current programme. Particular emphasis is placed on the separation of oxygen from air.
White light speckle method with tandem plates for 3-D displacement and deformation measurement on curved surfaces (1981)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text F. P. Chiang and A. Asundi, "White light speckle method with tandem plates for 3-D displacement and deformation measurement on curved surfaces," Appl. Opt. 20, 2167-2169 (1981) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Head-to-head efficacy and safety of rivaroxaban, apixaban, and dabigatran in an observational nationwide targeted trial (2022)

We demonstrated significant differences in outcomes between the three studied DOACs. The results emphasize the need for randomized controlled trials that will compare rivaroxaban, apixaban, and dabigatran in order to better guide the selection among them.
New modelling formalism for control programs of flexible manufacturing systems (2012)

Proposed in this paper is a modelling formalism, called the FMS control model, which is able to provide a detailed guideline for the implementation of the FMS control program (PLC program). Although, there are numerous simulation models for FMSs describing the system dynamics at the level of discrete event simulation, they cannot be fully utilised for the generation of a real control program involving sensors and actuators. Due to this, PLC programs for FMSs are usually done by the repetitive method of code writing, testing, and debugging until the control objectives are achieved. This is an error-prone and time-consuming task. The proposed FMS control model is described at the level of sensors and actuators. It can support the PLC program generation from the model. Since the FMS control model has been developed by expanding the DEVS formalism, it has a well-defined formalism. The proposed methodology has been implemented and test runs were made.
Field application and evaluation of a rapid immunochromatographic test for detection of Plasmodium falciparum infection among the inhabitants of Lao PDR. (2003)

Field application and evaluation of a rapid immunochromatographic test (ICT) for detection of Plasmodium falciparum infection were performed in 13 villages in a southern province of Lao PDR in 1999. More than 2,000 inhabitants, accounting for 61.8% of the total estimated population, were examined. Malaria infection was confirmed in all villages surveyed by ICT and microscopic diagnosis. The positive rates of P. falciparum malaria by microscopy ranged from 9.7% to 59.2% (mean 27.2%), whereas by ICT they were from 11.6% to 64.5% (mean 29.8%). The positive rates by ICT were generally higher in 8 out of 13 villages. However, a significant difference between the positive rates by microscopy and ICT was not observed in all villages. Plasmodium falciparum infection was actually confirmed by microscopy in 84.1% of specimens that tested positive by ICT. The results by ICT were consistent with those of the microscopic diagnosis, the discrepancy of the results was less than 10% (141/2,066). The ICT was falsely-positive in 4.7% and falsely-negative in 2.1% of the test cases. These results showed the efficacy of ICT not only in the diagnosis of the respective cases, but also in the mass-examination in the field.
Consensus “Cystic Fibrosis: definition, diagnostic criteria, treatment” Section “Microbiology and Epidemiology of chronic respiratory infections in cystic fibrosis” (2016)

The main causative agents of lung infection in patients with cystic fibrosis (CF) are P. aeruginosa, S. aureus and H. influenzae. In the last decade, gram-negative nonfermentative microorganisms (NFMO) - Вurkholderia cepacia complex (Bcc), Stenotrophomonas maltophilia, Achromobacter xylosoxidans and non-tuberculous mycobacteria, fungi of the genus Aspergillus have acquired the clinical significance. It is found that the chronic lung infection in 2/3 of the cases caused by association of microorganisms. Among hospitalized patients, in contrast to outpatients, these associations are represented by two, three or more species of microorganisms. The associations of P. aeruginosa + S. aureus (18,2 %) and P. aeruginosa + Bcc (9,1 %) are the most common. Other representatives - A. xylosoxidans, S. maltophilia and A. baumanii - is often identified in the associations of microorganisms. The focuses of chronic lung infections are formed in patients with increasing age. The dominant pathogens are P. aeruginosa and S. aureus. The methicillinresistant staphylococci and P. aeruginosa strains with a mucoid phenotype are of particular importance for cystic fibrosis patients. Bcc isolates from cystic fibrosis patients in Russia often belong to genomovar III A-B. cenocepacia. The Bcc strains colonize the lower airways of patients with CF and are able for long-term persistence and transmission from patient to patient. The resistance to many antibiotics is the main feature of the P. aeruginosa, S. aureus and Bcc strains. The strains of microorganisms with atypical phenotype (small colony variants) are formed under the action of the antibiotic. Infections caused by Bcc and other NFMO are difficult to identify and we need to use a wide range of bacteriological, biochemical, molecular biological techniques and mass spectrometry.
Organometall‐Imide – Höhervalente Derivate der d‐Metall‐Säuren, 1 Neue Organometall‐Imide des Molybdäns und Wolframs — die direkte Einführung der Cyclopentadienyl‐Gruppe durch Maskierung der hohen Oxidationsstufe (1991)

Organometallic Imido Complexes – Higher Valent Derivatives of the d‐Metal Acids, 1. – New Organometallic Imido Complexes of Molybdenum and Tungsten – Direct Introduction of the Cyclopentadienyl Group by Masking the High‐Oxidation State The molybdenum(VI)bis( tert ‐butylimido) complex MO(N t Bu) 2 ‐Cl 2 is converted into the novel organomolybdenum(VI) derivative (η 5 ‐C 5 H 5 )MO(N t Bu) 2 Cl ( 1 ) in excellent yield. The preparation of the pyridine complex W(N t Bu) 2 Cl 2 py 2 ( 2 ) provides a convenient starting material for an effective synthesis of the related complex (η 5 ‐C 5 H 5 )W(N t Bu) 2 Cl ( 4 ).
A novel broadband microstrip-fed wide slot antenna with double rejection zeros (2003)

A novel broadband microstrip-fed slot antenna with double rejection zeros is proposed and developed by constructing simultaneously a wide-slot radiator and a quarter-wavelength microstrip line resonator. A comprehensive explanation of its operating principle is given by using an equivalent two-pole filtering network, in which the radiation resistance is perceived as the output impedance. Extensive numerical results are then obtained using a commercial electromagnetic simulator to demonstrate its attractive broadband feature. Finally, a few antenna samples are designed, fabricated, and measured to verify the predicted performance. Experimental results exhibit that the bandwidth of this proposed antenna configuration is significantly increased, by up to 32.0%, as compared to 9.0% for its traditional counterpart.
The multi-track angiography catheter: a new tool for complex catheterisation in congenital heart disease. (1996)

The Multi-Track Angio catheter system allows for high quality angiography and pressure recordings during diagnostic and interventional cardiac catheterisation. The advantage of the system is that both angiography and pressure recordings can be performed repeatedly from stable catheter positions using a previously placed guidewire. This reduces the need for guidewire manipulations or catheter exchanges and decreases procedure time and the risk of complications.
A low‐cost density reference phantom for computed tomography (2009)

The authors characterized a commercially available foam composed of polyurethane and polyisocyanurate which is marketed for modeling parts in the aircraft, automotive, and related industries. The authors found that the foam may be suitable for use as a density reference standard in the range below -400 Hounsfield units. This range is coincident with the density of lung tissue. The foam may be helpful in making the diagnosis of lung disease more systematic.
Application of risk-based methods for inspection of nuclear power plant components (1992)

In-service inspections (ISIs) can play a significant role in minimizing equipment and structural failures. All aspects of inspections, i.e., objectives, method, timing, and the acceptance criteria for detected flaws can affect the probability of component failure. Where ISI programs exist, they are primarily based on prior experience and engineering judgment. At best, some include an implicit consideration of risk (probability of failure multiplied by consequence). Since late 1988, a multidisciplined American Society of Mechanical Engineers (ASME) Research Task Force on Risk-Based Inspection Guidelines has been addressing the general question of how to formally incorporate risk considerations into plans and requirements for the ISI of components and structural systems. The task force and steering committee that guided the project have concluded that appropriate analytical methods exist for evaluating and quantifying risks associated with pressure boundary and structural failures. With the support of about a dozen industry and government organizations, the research group has recommended a general methodology for establishing a risk-based inspection program that could be applied to any nuclear system or structural system.
14‐19 Education: legacy, opportunities and challenges (1998)

ABSTRACT This paper begins with an analysis of the changes in 14—19 education from the beginning of the 1980s until the last government's White Paper 14‐19 Education: Learning to Compete, which appeared in March 1997. It then considers the tensions in this legacy before exploring some of the issues that might be involved in realising the Labour Party's aims as set out, before the General Election, in their policy document Aiming Higher. Finally, the authors speculate, in light of developments since the Labour Party's victory on 2 May, on a possible scenario for the next decade and outline the kind of 14–19 system that we might be wanting to try to develop in the future.
Sustained-Release Ganciclovir Therapy for Treatment of Cytomegalovirus Retinitis (1992)

A surgically implantable device for sustained intravitreal release of ganciclovir has been developed. The device delivers ganciclovir intraocularly over approximately 4 to 5 months. Eight patients with acquired immunodeficiency syndrome (AIDS) and associated cytomegalovirus (CMV) retinitis were recruited as part of a phase 1 study. Thirteen eyes with active CMV retinitis underwent surgical implantation of the ganciclovir device. All eyes showed resolution of the CMV retinitis; none showed progression. Visual acuity remained unchanged in three eyes, improved in six eyes, and decreased in four eyes. Surgical complications included mild vitreous hemorrhage, astigmatism, and suprachoroidal placement of the device. Retinal detachment occurred in three eyes as the retinitis resolved. This new intraocular drug delivery system offers many advantages compared with intravenous therapy or repeated intravitreal ganciclovir injections for the management of CMV retinitis in patients with AIDS.
Role of Follicular Dendritic Cells in the Early HIV‐1 Infection: In vitro Model without Specific Antibody (2004)

About 90% of HIV-1 RNA in the lymph nodes is reported to localize in follicular dendritic cellsnetwork (FDC-NW) as early as several days after infection and as much as that in the late stage. But the mechanism remains to be fully understood. To elucidate the role of follicular dendritic cells (FDC) in the early stage of HIV-1 infection, FDC-like cell strains (FDCLC) were established and they were characterized in the co-culture system with T cells for their effect on HIV-1 trapping and replication in p24 immunoassay, immunohistochemistry as well as confocal and electronmicroscopy. Established FDCLC were positive for CNA-42, S-100alpha and intercellular desmosome-like junctions. L-SIGN and DC-SIGN were also detected in FDCLC. Alu-HIV-1 PCR analysis showed no HIV-1 integration in FDCLC. FDCLC trapped HIV-1 and transferred them to uninfected MOLT-4 T cells (MOLT-4) efficiently in the absence of specific antibody. FDCLC also accelerated HIV-1 replication in HIV-1-pre-exposed MOLT-4. These unique FDCLC effects were explained, at least partly, by the fact that FDCLC up-regulated CD4 expression in MOLT-4 and helped T cells escape from apoptosis in the co-culture. These data suggest that FDC/FDCLC engage not only in trapping but also in active expansion of HIV-1 in the absence of specific antibody.
Coulomb Blockade Observed in InAs/AlGaSb Nanostructures Produced by an Atomic Force Microscope Oxidation Process (1999)

We fabricated and characterized an InAs/AlGaSb single electron transistor produced by the atomic force microscope (AFM) oxidation process. The structure of the transistor we developed has two in-plane gate electrodes which are separated from the current channel by a 0.1-µm-wide gap defined by AFM oxidation and selective GaSb/AlGaSb and InAs etching processes. A complete transistor operation, including clear pinch-off characteristics is achieved by applying negative gate voltages at 4.2 K. Near the pinch-off, an island is formed in the middle of the InAs channel by depleting narrow InAs constrictions fabricated on both sides of the island. We observed a Coulomb gap of 1.6 mV, which is consistent with the estimated self-capacitance of the island. The oscillatory behavior in the I – V characteristics suggests a contribution of quantum effects to the electron tunneling process.
Automatically patching errors in deployed software (2009)

We present ClearView, a system for automatically patching errors in deployed software. ClearView works on stripped Windows x86 binaries without any need for source code, debugging information, or other external information, and without human intervention.
Effects of Atorvastatin on Bone in Postmenopausal Women with Dyslipidemia: A Double-Blind, Placebo-Controlled, Dose-Ranging Trial (2007)

Clinically relevant doses of atorvastatin that lower lipid levels had no effect on bone mineral density or biochemical indices of bone metabolism in this study, suggesting that such oral agents are not useful in the prevention or treatment of osteoporosis.
IMPLEMENTATION OF A SYSTEMS APPROACH TO PAVEMENT DESIGN (ABRIDGMENT) (1974)

A systems analysis model for pavements has been implemented in Florida, Kansas, and Louisiana. A computer program for the design of flexible pavements using the AASHO Interim Guide as a structural subsystem has been developed and can be implemented within any state. It incorporates most of the major variable involved in pavement design in a realistic way. Revisions required to accommodate the unique factors of each state can usually be made with a minimum of reprogramming effort. Collateral improvements such as construction cost simulation and pavement feedback data systems are required to provide reliable input data and, in the long run, to verify the assumptions made in design.
Amorphous and Crystalline Polyesters Based on 1,4‐Cyclohexanedimethanol (2004)

This chapter contains sections titled: Notation Introduction 1,4-Cyclohexanedimethanol 1,3- and 1,2-Cyclohexanedimethanol: Other CHDM Isomers Synthesis of CHDM-based Polyesters Poly(1,4-Cyclohexylenedimethylene Terephthalate) Glycol-modified PCT Copolyester: Preparation and Properties CHDM-modified PET Copolyester: Preparation and Properties Dibasic-acid-modified PCT Copolyester: Preparation and Properties Modification of CHDM-based Polyesters with Other Glycols and Acids Acknowledgments References
Red Cell Preservation in Protein‐Poor Media: III. Protection Against in vitro Hemolysis (1981)

Red cells stored under blood bank conditions normally show less than 1% spontaneous in vitro hemolysis even after 5 weeks; larger hemolysis may be found if the cells are suspended and stored in a saline-adenine-glucose (SAG) solution with very little trapped plasma. Delay of the addition of the suspension medium, return of 25 ml plasma after a maximal plasma harvest, addition of mannitol 10-30 mmol.1(-1) to the suspension medium were alternative and effective ways of keeping the spontaneous lysis within normal limits. Mechanical traumatization (centrifugation or shaking) caused considerably more damage to the red cells when these were highly concentrated than when they were diluted. A cell suspension in SAG is a more suitable product for hemotherapy than strongly packed red cell concentrates.
Supplementary Figures 1 - 5, Tables 1 - 4 from αB-Crystallin: A Novel Regulator of Breast Cancer Metastasis to the Brain (2023)

&lt;p&gt;PDF file - 797K, Figure S1. Barrier phenotype of human brain microvascular endothelial cells and astrocytes in monocultures and co-cultures. Figure S2. alpha/beta-crystallin does not affect cell viability of TNBC cells in standard monolayer culture. Figure S3. alpha/beta-crystallin overexpression increases liver metastases in an orthotopic model of TNBC. Figure S4. Silencing alpha/beta-crystallin inhibits liver metastases in an orthotopic model of TNBC. Figure S5. alpha/beta-crystallin does not affect proliferation or apoptosis in primary mammary tumors and brain metastatic lesions determined at autopsy. Table S1. Patient characteristics Table S2. alpha/beta-crystallin expression in paired tumors. Table S3. Association of alpha/beta-crystallin expression with breast cancer subtype. Table S4. Incidence of metastases in mice in orthotopic models of TNBC .&lt;/p&gt;
An interactive fur modeling technique (1997)

A technique for modeling fur, but not long human hair, quickly, using the facilities of common graphics workstations is described. The user selects a variety of parameters to achieve the desired appearance for a particular animal, such as hair density, length, stiffness, and color properties. Undercoat and overcoat may have separate specifications, and degrees of randomness may be specified, for added realism. Standard GL facilities are used for modeling, lighting, and rendering. Hair density is automatically adjusted for viewing distance to compensate for the limit of single pixel resolution, thus avoiding the tendency to ''melt'' into a surface of uniform appearance. Gravitational effects are approximated. Four drawing methods are compared: single line, polyline, nurbs curve, and nurbs surface. The polyline method is judged to offer reasonable realism at substantially faster rendering rates than previously reported hair techniques.
Clinical Characteristics of Diabetic Patients Transferred to Korean Referral Hospitals (2014)

We investigated the clinical characteristics of diabetic patients and identified specific problems in diabetic management prior to the transfer. We also found several problems in the medical system, which were divided into three medical institutions having different roles in Korea. Our findings suggested that the relationships among medical institutions have to be improved, particularly for diabetes.
Validation Of A Functional Biomarker Of Brain Energy Deficit In Huntington Disease (P1.011) (2014)

Objective: To validate functional biomarkers of brain energy deficit in Huntington disease (HD) using 31P-magnetic resonance spectroscopy (MRS). Background: HD is an autosomal dominant neurodegenerative disease caused by a CAG repeat expansion in the HTT gene. Energy metabolism has been a major focus of HD research for many years due to several observations in both patients and models of the disease. However, there are currently no validated in vivo biomarkers of brain energy metabolism in HD. Methods: We coupled noninvasive 31P-MRS with activation of the occipital cortex in order to measure the levels of phosphocreatine (PCr) and inorganic phosphate (Pi) before (rest), during (activation) and after (recovery) a visual stimulus. We studied 25 HD patients at an early stage of the disease (including 10 patients scanned 18 months before), 10 presymptomatic carriers and 28 controls. Results: In controls, we confirmed a significant increase in Pi/PCr ratio (p=0.022) during brain activation - reflecting increased ATP synthesis and ADP levels - followed by a significant return to baseline levels during recovery (p=0.008). In HD patients, we confirmed an abnormal energetic profile with unchanged Pi/PCr ratio during and after visual stimulation, reflecting altered mitochondrial bioenergetics as previously shown. In HD patients, the MRS profiles were stable over one-month and eighteen-month intervals. Importantly, brain energy profile was also abnormal in the presymptomatic group. Conclusions: We confirmed that we can reliably capture an abnormal energetic profile in HD in response to visual cortex activation. This profile is stable over time suggesting that it can be used as an outcome measure in clinical trials, especially those targeting the mitochondria. The identification of an abnormal profile in presymptomatic carriers confirms that altered bioenergetics play an early role in the pathogenesis of HD and are, therefore, a therapeutic target of choice. Study supported by Ipsen.
Refractory hyperglycaemia induced by glucose-insulin-potassium infusion in acute myocardial infarction. (2006)

BACKGROUND: Recent randomised clinical trials have not confirmed the beneficial effects of glucose-insulin-potassium (GIK) infusion observed in experimental models of myocardial ischaemia and infarction. METHODS: We investigated glucose levels and insulin dose in 107 patients treated with reperfusion therapy and GIK for acute myocardial infarction. RESULTS: Despite high insulin infusion rates, persistent hyperglycaemia occurred in 37% of the patients. These patients had significantly larger infarctions, as measured by enzyme release (p=0.006). In a multivariate model predicting high troponin levels, refractory hyperglycaemia remained a significant parameter (p=0.02). CONCLUSION: These findings suggest that refractory hyperglycaemia caused by high-dose glucose infusion may, at least in part, explain the discrepancy between the experimental and clinical data.