gebhart/patrepeval huggingface dataset:
Molecular Characterization of Thyroid Toxicity: Anchoring Gene Expression Profiles to Biochemical and Pathologic End Points (2005)

Organic iodides have been shown to induce thyroid hypertrophy and increase alterations in colloid in rats, although the mechanism involved in this toxicity is unclear. To evaluate the effect that free iodide has on thyroid toxicity, we exposed rats for 2 weeks by daily gavage to sodium iodide (NaI). To compare the effects of compounds with alternative mechanisms (increased thyroid hormone metabolism and decreased thyroid hormone synthesis, respectively), we also examined phenobarbital (PB) and propylthiouracil (PTU) as model thyroid toxicants. Follicular cell hypertrophy and pale-staining colloid were present in thyroid glands from PB-treated rats, and more severe hypertrophy/colloid changes along with diffuse hyperplasia were present in thyroid glands from PTU-treated rats. In PB- and PTU-treated rats, thyroid-stimulating hormone (TSH) levels were significantly elevated, and both thyroxine and triiodothyronine hormone levels were significantly decreased. PB induced hepatic uridine diphosphate-glucuronyltransferase (UDPGT) activity almost 2-fold, whereas PTU reduced hepatic 5 -deiodinase I (5 -DI) activity to < 10% of control in support of previous reports regarding the mechanism of action of each chemical. NaI also significantly altered liver weights and UDPGT activity but did not affect thyroid hormone levels or thyroid pathology. Thyroid gene expression analyses using Affymetrix U34A GeneChips, a regularized t-test, and Gene Map Annotator and Pathway Profiler demonstrated significant changes in rhodopsin-like G-protein-coupled receptor transcripts from all chemicals tested. NaI demonstrated dose-dependent changes in multiple oxidative stress-related genes, as also determined by principal component and linear regression analyses. Differential transcript profiles, possibly relevant to rodent follicular cell tumor outcomes, were observed in rats exposed to PB and PTU, including genes involved in Wnt signaling and ribosomal protein expression.
Persistent Carotid-Vertebrobasilar Anastomosis: Radiologic Findings (1998)

Purpose : To evaluate the radiologic findings of carotid-vertebrobasilar anastomosis and associated anomalies.Materials and Methods : Thirteen patients with fourteen cases of carotid-vertebrobasilar anastomosis collected from January 1992 to December 1997 were reviewed. Clinical diagnosis refered for cerebral angiography were cerebral infarction(n=3), intracranial hemorrhage(n=2), subarachnoid hemorrhage(n=1), brain tumor(n=3), arteriovenous malformation(n=3) and trigeminal neuralgia(n=1). Cerebral angiograms and clinical symptoms were retrospectively analyzed. Results : The fourteen carotid-vertebrobasilar anastomosis consisted of eleven cases of persistent trigeminal artery and three cases of type I proatantal intersegmental artery. Persistent trigeminal arteries were associated with anterior communicating artery aneurysm(n=1), posterior fossa arteriovenous malformation(n=2) and persistent trigeminal artery variant(n=5). Type I proatantal intersegmental arteries were associated with hypoplastic vertebral arteries(n=2): only proximal segment in one, and proximal and distal segments in one case. Only one patient had clinical symptom related to the carotid-vertebrobasilar anastomosis which was trigeminal neuralgia. Conclusion : Knowledge of the anatomical and radiologic findings of carotid-vertebrobasilar anastomosis and associated anomalies will aid in the accurate diagnosis of neurovascular disease and prevent possible complications during surgical and interventional procedures.
The Way In Is the Way Out: Poetry Writing in the Classroom (1998)

Describes how two teachers approach poetry writing with at-risk high school students over a 12-week period, structuring activities to initiate poetry as language play, selecting model poems that are developmentally appropriate, and organizing writing assignments that encourage students to draw on their individual experiences. Discusses conducting a poetry workshop and evaluating students’ poetry.
Improved Ullmann Synthesis of Diaryl Ethers (1983)

Abstract Several diaryl ethers have been synthesized by using indefinitely stable and easily available copper(I) phenyl-acetylenide as condensing agent in Ullmann condensation reaction.
Submaximal angioplasty in the treatment of patients with symptomatic ICAD: a systematic review and meta-analysis (2019)

The findings suggest that SA might be a promising alternative treatment in the treatment of symptomatic ICAD due to its favorable technical profile, periprocedural safety, and long-term efficacy. A randomized clinical trial is warranted to compare the safety and efficacy of SA with 'gold standard' medical treatment.
Anomalous thermoelectric power inSrFeO3−δfrom charge ordering and phase separation (2007)

We report the results from thermoelectric power (TEP), magnetization, and resistivity measurements on a series of oxygen-deficient $\mathrm{Sr}\mathrm{Fe}{\mathrm{O}}_{3\ensuremath{-}\ensuremath{\delta}}$ samples. We find a large anomalous decrease in the TEP below $\ensuremath{\sim}70\phantom{\rule{0.3em}{0ex}}\mathrm{K}$ when $\mathrm{Sr}\mathrm{Fe}{\mathrm{O}}_{3\ensuremath{-}\ensuremath{\delta}}$ is close to the tetragonal ${\mathrm{Sr}}_{8}{\mathrm{Fe}}_{8}{\mathrm{O}}_{23}$ $(3\ensuremath{-}\ensuremath{\delta}=2.875)$ phase. This drop decreases and disappears when $\mathrm{Sr}\mathrm{Fe}{\mathrm{O}}_{3\ensuremath{-}\ensuremath{\delta}}$ approaches the orthorhombic ${\mathrm{Sr}}_{4}{\mathrm{Fe}}_{4}{\mathrm{O}}_{11}$ $(3\ensuremath{-}\ensuremath{\delta}=2.75)$ phase. Similar to other researchers, we find evidence for the onset of antiferromagnetic order at a similar temperature as well as a jump in the resistivity. We argue that the large drop in the TEP is a consequence of Verwey-like charge ordering in the ${\mathrm{Sr}}_{8}{\mathrm{Fe}}_{8}{\mathrm{O}}_{23}$ phase. The decrease in the TEP drop as $\mathrm{Sr}\mathrm{Fe}{\mathrm{O}}_{3\ensuremath{-}\ensuremath{\delta}}$ approaches the ${\mathrm{Sr}}_{4}{\mathrm{Fe}}_{4}{\mathrm{O}}_{11}$ phase is consistent with $\mathrm{Sr}\mathrm{Fe}{\mathrm{O}}_{3\ensuremath{-}\ensuremath{\delta}}$ being a mixture of the ${\mathrm{Sr}}_{8}{\mathrm{Fe}}_{8}{\mathrm{O}}_{23}$ and ${\mathrm{Sr}}_{4}{\mathrm{Fe}}_{4}{\mathrm{O}}_{11}$ phases.
Evaluation of adjunctive mycophenolate for large vessel giant cell arteritis (2020)

To our knowledge, this is the first attempt to assess the effectiveness of any specific agent in LV-GCA. MYC might be both effective in reducing CS exposure and well tolerated in this subpopulation. A future randomized controlled trial is warranted.
Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a (1997)

The human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein causes cellular transformation by deregulating important cellular processes such as DNA repair, transcription, signal transduction, proliferation, and growth. Although it is clear that normal cell cycle control is deregulated during HTLV-1-induced cellular transformation, the effects of Tax on cell cycle control are not well understood. Flow cytometric analyses of human T cells indicate that cell cycle arrest in late G1, at or before the G1/S restriction point, by p16INK4a is relieved by Tax. Furthermore, Tax-dependent stimulation of 5-bromo-2'-deoxyuridine incorporation and transcriptional activation is inhibited by p16INK4a. This result suggests that p16INK4a is able to block Tax-dependent stimulation of DNA synthesis and cell cycle progression into S phase. In vitro binding assays with recombinant glutathione S-transferase fusion proteins and [35S]methionine-labeled proteins indicate that Tax binds specifically with p16INK4a but not with either p21cip1 or p27kip1. Furthermore, sequential immunoprecipitation assays with specific antisera and [35S]methionine-labeled cell lysates subsequent to coexpression with Tax and p16INK4a indicate that the two proteins form complexes in vivo. Immunocomplex kinase assays with cyclin-dependent kinase 4 antiserum indicate that Tax blocks the inhibition of cdk4 kinase activity by p16INK4a. This study identifies p16INK4a as a novel cellular target for Tax and suggests that the inactivation of p16INK4a function is a mechanism of cell cycle deregulation by Tax.
A FROST-HEAVE-PROOFING TECHNIQUE FOR GROUND ANCHORAGES (2004)

本論文は, グラウンドアンカー頭部に設置した皿ばねの凍上対策としての効果の検証を目的として実施した, 模型地盤の凍上実験結果について述べている. 実験ではアンカーを設置しないで地表面の拘束条件を変化させた場合, および模型地盤内にアンカーを設置し, その頭部に皿ばねを設置した場合と設置しない場合について実施した. その結果, 以下の結論を得た. 1) 凍上時のアンカー緊張力と定着板の凍上変位は双曲線の関係にある. 2) アンカー頭部に皿ばねを設置することによって, 凍上現象に伴う緊張力増加は抑制されるという結果が得られ, 皿ばねの凍上対策としての効果が検証できた. さらに, 本論文ではグラウンドアンカーの凍上対策としての皿ばねの仕様の決定方法を示している.
BALANCING TEXTURE AND OTHER SENSORY FEATURES IN REDUCED FAT SHORT‐DOUGH BISCUITS (2011)

ABSTRACT Shortening in short‐dough biscuits was replaced by a new ingredient, N‐Dulge (a mixture of tapioca dextrin and tapioca starch) at two different levels (10 and 20%). The texture was balanced by replacing part of the flour with resistant starch (RS) (20 and 40%). Nine different formulations were tested by a trained panel and by consumers. The results also correlated with the textural characteristics. The trained panel results showed that the fat replacer increased the hardness and crumbliness, and that these effects were balanced out by the addition of RS. These results correlated well with the instrumental texture parameters. The consumers did not find significant differences in acceptability between the control biscuits (no replacement) and the biscuits with 10% of fat replaced by N‐Dulge and 20% of flour replaced by RS. PRACTICAL APPLICATIONS Biscuits are widely consumed. Short‐dough biscuits, characterized by a high fat content, are one of the most popular types. Nutritionally, it would be advantageous to decrease their fat content while keeping their sensory properties unchanged.
Influence of pH on the heat-induced proteolysis of casein molecules (2001)

Proteolysis of sodium caseinate solution (24·5 g/l) induced by heat treatment at 120 °C at different pH values was studied by measuring nitrogen content and relative fluorescence intensity in the 4% trichloroacetic acid filtrates. The low molar mass peptides corresponding to the soluble nitrogen were identified using liquid chromatography/tandem mass spectrometry. Increase in proteolysis, deduced from the increase in soluble nitrogen content, was observed with heating time (10, 20 and 30 min) and pH (6·0, 7·0, 8·0 and 9·0). The fluorescence measurements showed that the release of peptides containing tryptophan was minimal at pH ∼ 7·0. In parallel, eighteen low molar mass peptides were characterized, of which four came from κ-casein, nine from β-casein and five from α s1 -casein. Peptides were preferentially released under alkaline conditions.
Toxicity of Fatty Acid Salts to German and American Cockroaches (2008)

The toxicity of fatty acid salts to German, Blattella germanica (L.), and American cockroaches, Periplaneta americana (L.), was evaluated. Potassium and sodium laurate caused up to 95% mortality of German cockroaches and 100% mortality of American cockroaches. Even-numbered potassium fatty acid salts, C8–C18, were assessed for toxicity at 0.125, 0.25, 0.5, 1, and 2% concentrations by a 30-s immersion of cockroaches. The more soluble of the fatty acid salts at 2% concentration caused 65–95% mortality of German cockroaches and 100% mortality of American cockroaches. Potassium oleate, C18, was most toxic to both German (LC50 = 0.36%) and American (LC50 = 0.17%) cockroaches. Fatty acid salt solutions on a substrate were tested by placing cockroaches in contact with treated floor tiles immediately after application (wet) or after the solutions had dried. Sodium laurate and potassium caprate caused mortality of German (62 ± 17.4 and 58 ± 12.6%, respectively) and American cockroaches (52 ± 18.5 and 28 ± 4.9%, respectively) on wet tiles, whereas potassium oleate caused mortality of German cockroaches (67 ± 14.1%) only. Dry fatty acids caused no mortality among exposed cockroaches. Fatty acid salt solutions can be effective in killing German and American cockroaches but only when insects are thoroughly wetted with 1–2% fatty acid salt solutions.
Real-Time Channel Management in WLANs: Deep Reinforcement Learning versus Heuristics (2021)

Today's WLANs rely on a centralized Access Controller (AC) entity for managing distributed wireless Access Points (APs) to which user devices connect. The availability of real-time analytics at the AC opens the possibility to automate the allocation of scarce radio resources, continuously adapting to changes in traffic demands. Often, the allocation problem is formulated in terms of weighted graph coloring, which is NP-hard, and custom heuristics are used to find satisfactory solutions. In this paper, we contrast solutions that are based on (and even improve) state of the art heuristics to a data-driven solution that leverages Deep Reinforcement Learning (DRL). Based on both simulation results as well as experiments in a real deployment, we show that our DRL-based scheme not only learns to solve the complex combinatorial problem in bounded time, outperforming heuristics, but it also exhibits appealing generalization properties, e.g. to different network sizes and densities.
Effects of presynchronization and eCG on pregnancy rates to GnRH-based, fixed-time artificial insemination in beef heifers (2010)

Three experiments were conducted to determine the effects of presynchronization and treatment with equine chorionic gonadotropin (eCG) on corpus luteum (CL) and ovarian follicular development, plasma progesterone concentrations, and pregnancy rates in beef heifers subjected to a gonadotropin releasing hormone (GnRH)-based, fixed-timed AI (TAI) protocol. All heifers were given GnRH on day 0, prostaglandin F 2α (PGF) on day 7, and a second GnRH on day 9 concurrent with TAI (54 h after PGF). In exp. 1 (N = 148), presynchronization with PGF (days -22 and -11) decreased the percentage of heifers with non-luteal plasma progesterone concentrations on day 0 (5.4 vs 29.7%) and day 7 (0 vs 11.6%; P &lt; 0.05), but not on day 9 (74.3 vs. 66.2%; P &gt; 0.20), and reduced the number of heifers in estrus and bred before TAI (P &lt; 0.05). Although presynchronization reduced preovulatory follicle diameter (12.9 ± 0.3 vs. 14.9 ± 0.3 mm; mean ± SEM; P &lt; 0.01), it did not affect TAI pregnancy rates (36.5 vs. 29.7%; P &gt; 0.20). In exp. 2, heifers (N = 128) were presynchronized with melengestrol acetate (MGA) (days -27 to -12), and received a controlled internal drug release (CIDR) on day 0; on day 7, half were given 300 IU of eCG at CIDR removal. Treatment with eCG tended to increase preovulatory follicle diameter in heifers that did not ovulate to GnRH on day 0 (P = 0.06), but did not affect the percentage of heifers with non-luteal plasma progesterone concentrations on day 9 (57.8 vs. 57.8%) or TAI pregnancy rates (48.4 vs. 53.1%; P &gt; 0.20). Experiment 3 was a 2 × 2 factorial arrangement of presynchronization (PGF concurrent with a CIDR on day -7) and eCG treatments (on day 7) applied to heifers in three herds (A, N = 150, B, N = 260 and C, N = 40). All heifers had a once-used CIDR from days 0 to 7. Presynchronization increased the percentage of heifers (Herd A) with low-luteal plasma progesterone concentrations on day 0 (70.7 vs. 22.7%) and day 7 (90.7 vs. 53.3%; P &lt; 0.01), but did not affect the percentage of heifers with non-luteal concentrations of progesterone on day 9 (97.3 vs. 93.3%; P &gt; 0.20). Combined for all herds, presynchronization reduced the prevalence of a CL on day 0 (23.5 vs. 73.7%; P &lt; 0.01), and increased the prevalence of follicles ≥ 10 mm on day 7 (96.8 vs. 86.7%; P &lt; 0.01); however, TAI pregnancy rates (195/439 = 44.4%) were not improved by either presynchronization or eCG treatment (P &gt; 0.20).Key words: Presynchronization, equine chorionic gonadotropin, GnRH, fixed-time artificial insemination, progesterone
Monitoring the Heterogeneous Reaction of LiH and LiOH with H2O and CO2 by Diffuse Reflectance Infrared Fourier Transform Spectroscopy (1983)

Measurement of the reaction of water vapor and carbon dioxide with lithium compounds such as LiH and LiOH has been carried out in situ using diffuse reflectance infrared Fourier transform (DRIFT) Spectroscopy. The bakeable high-vacuum cell, based on a modification of a commercial diffuse reflectance infrared cell is described along with means for controlling the gaseous and thermal environment.
An UWB planar out-of-phase power divider employing microstrip-slot and parallel stripline-microstrip transitions (2006)

The design of a planar out-of-phase power divider with an ultra wideband (UWB) performance is presented. The device employs two substrates with a common ground plane. A coupling between two microstrip lines on the top and bottom substrate layers through a slot in the common ground plane, and a transition from two microstrip lines to a parallel stripline are used to achieve an UWB operation. The simulated and measured results of the proposed divider reveal low insertion losses, good return loss at the three ports and fine isolation between the two output ports across the band 3.1 to more than 11 GHz with high phase stability.
The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma (2020)

Abstract Background Ewing sarcoma is an aggressive bone cancer in children and young adults that contains a pathognomonic chromosomal translocation: t(11;22)(q24;q12). The encoded protein, EWS/FLI, fuses the low-complexity amino-terminal portion of EWS to the carboxyl-terminus of FLI. The FLI portion contains an ETS DNA-binding domain and adjacent amino- and carboxyl-regions. Early studies using non-Ewing sarcoma cellular models provided conflicting information on the role of these adjacent regions in the oncogenic function of EWS/FLI. We therefore sought to define the specific contributions of each FLI region to EWS/FLI activity in an appropriate Ewing model, and in doing so, to better understand Ewing sarcoma development mediated by the fusion protein. Methods We used a “knock-down/rescue” system to replace endogenous EWS/FLI expression with mutant forms of the protein in Ewing sarcoma cells and tested these for oncogenic transformation using soft-agar colony forming assays. These data were complemented by DNA-binding assays using fluorescence anisotropy, genomic localization assays using CUT&amp;RUN, transcriptional regulation studies using luciferase reporter assays and RNA-sequencing, as well as chromatin accessibility assays using ATAC-sequencing. Results We found that the DNA-binding domain and short flanking regions of FLI were required for oncogenic transformation, gene expression, genomic localization and chromatin accessibility when fused to the amino-terminal EWS-portion from EWS/FLI, but that the remaining regions of FLI were dispensable for these functions. Removal of a carboxyl-terminal alpha-helix from the short flanking regions of the DNA-binding domain of FLI created a hypomorphic EWS/FLI that retained normal DNA binding, genomic localization, and chromatin accessibility, but had significantly restricted transcriptional activity and a near total loss of oncogenic transformational capacity. Conclusions The DNA-binding domain and carboxyl-terminal short flanking region of FLI are the only portions of FLI required for EWS/FLI-mediated oncogenic transformation in a Ewing sarcoma cellular context. In addition to the well-defined DNA-binding function of FLI, this additional alpha-helix immediately downstream of the DNA-binding domain contributes a previously-undescribed function in gene regulation and oncogenic transformation. Understanding the function of this critical region could provide new therapeutic opportunities to target EWS/FLI in Ewing sarcoma.
Reasoning Strategies in Smart Cyber-Physical Systems (2015)

Cyber-physical systems are integrations of computerized physical things in the environment that are merged by communications, and computations using embedded systems and networks. To make the compo ...
Combination of Baseline LDH, Performance Status and Age as Integrated Algorithm to Identify Solid Tumor Patients with Higher Probability of Response to Anti PD-1 and PD-L1 Monoclonal Antibodies (2019)

Predictive biomarkers of response to immune-checkpoint inhibitors (ICIs) are an urgent clinical need. The aim of this study is to identify manageable parameters to use in clinical practice to select patients with higher probability of response to ICIs. Two-hundred-and-seventy-one consecutive metastatic solid tumor patients, treated from 2013 until 2017 with anti- Programmed death-ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) ICIs, were evaluated for baseline lactate dehydrogenase (LDH) serum level, performance status (PS), age, neutrophil-lymphocyte ratio, type of immunotherapy, number of metastatic sites, histology, and sex. A training and validation set were used to build and test models, respectively. The variables' effects were assessed through odds ratio estimates (OR) and area under the receive operating characteristic curves (AUC), from univariate and multivariate logistic regression models. A final multivariate model with LDH, age and PS showed significant ORs and an AUC of 0.771. Results were statistically validated and used to devise an Excel algorithm to calculate the patient's response probabilities. We implemented an interactive Excel algorithm based on three variables (baseline LDH serum level, age and PS) which is able to provide a higher performance in response prediction to ICIs compared with LDH alone. This tool could be used in a real-life setting to identify ICIs in responding patients.
Systematic Method to Assess Small-Signal Stability of DC-Distributed Power-System-Architecture (2013)

The objective of this paper is to present a simplified method to analyze small-signal stability of a power system and provide performance metrics for stability assessment of a given power-system-architecture. The stability margins are stated utilizing a concept of maximum peak criteria (MPC), derived from the behavior of an impedance-based sensitivity function that provides a single number to state the robustness of the stability of a well-defined minor-loop gain. For each minor-loop gain, defined at every system interface, the robustness of the stability is provided as a maximum value of the corresponding sensitivity function. Typically power systems comprise of various interfaces and, therefore, in order to compare different architecture solutions in terms of stability, a single number providing an overall measure of the whole system stability is required. The selected figure of merit is geometric average of each maximum peak value within the system, combined with the worst case value of system interfaces.