gebhart/patrepeval huggingface dataset:
Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes – a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC-MS (2021)

Histone acetylation is an important, reversible post-translational protein modification and a hallmark of epigenetic regulation. However, little is known about the dynamics of this process, due to the lack of analytical methods that can capture site-specific acetylation and deacetylation reactions. We present a new approach that combines metabolic and chemical labeling (CoMetChem) using uniformly 13C-labeled glucose and stable isotope labeled acetic anhydride. Thereby, chemically equivalent, fully acetylated histone species are generated enabling accurate relative quantification of site-specific lysine acetylation in tryptic peptides using high-resolution mass spectrometry. We show that CoMetChem enables site-specific quantification of the incorporation or loss of lysine acetylation over time, allowing the determination of reaction rates for acetylation and deacetylation. Thus, the CoMetChem methodology provides a comprehensive description of site-specific acetylation dynamics.
Thermal and thermoelastic dynamic analysis with Finite Element Analysis, Application to photothermal and thermoelastic microscopies », XVIII EUROSENSORS, Rome, Italy, september 12-15, 2004, (2004)

International audience
Place Recognition in Forests With Urquhart Tessellations (2020)

In this letter, we present a novel descriptor based on Urquhart tessellations derived from the position of trees in a forest. We propose a framework that uses these descriptors to detect previously seen observations and landmark correspondences, even with partial overlap and noise. We run loop closure detection experiments in simulation and real-world data map-merging from different flights of an Unmanned Aerial Vehicle (UAV) in a pine tree forest and show that our method outperforms state-of-the-art approaches in accuracy and robustness.
Energy-saving operation of an electric train at multiple service section based on sensitivity analysis of energy consumption to running time (2012)

An energy-saving train operation is theoretically studied in this paper. Case studies for showing trade-off relationship between train running time and energy consumption are numerically calculated and compared for minimizing energy through optimal time allocations among multiple inter-station sections. Effects of payload on the optimized results are carefully discussed in the study.
Electrochemical Liquid Liquid Synthesis of Semiconductor and Intermetallic Nanomaterials (2021)

This presentation describes the hybrid methodology of electrochemical liquid-liquid-solid (ec-LLS) crystal growth for the synthesis of semiconductor and intermetallic nanostructures. The premise of ec-LLS is that electrodeposition can be coupled with melt-crystal growth through the use of liquid metal cathodes. Electrodeposition of zero-valent metals and metalloids, followed by dissolution into and then precipitation out of the liquid metal, affords low-temperature and rapid crystal growth. This presentation first describes our latest understanding of the governing factors of ec-LLS processes for the preparation of semiconductor nanowires. Following, our latest results for the synthesis of intermetallic nanoparticles by ec-LLS will be demonstrated. The operative design rules for optimal liquid metal cathodes that afford tailored binary and ternary intermetallic nanoparticles will be discussed. An emphasis will be placed on ec-LLS reactions that produce catalytic intermetallic nanomaterials.
Difficult Nasal Polyposis: Evolving Treatments and Remedies (2013)

Program Description: Chronic sinusitis with nasal polyposis has a detrimental impact on quality of life and may exacerbate co‐existing conditions such as asthma. This miniseminar will outline the latest theories on disease pathogenesis as well as promote rational medical and surgical strategies for severe nasal polyposis management. Treatments designed to decrease reliance on systemic steroids, including surgical methods and complementary medical therapeutics such as topical steroid irrigations, macrolides, and anti‐leukotrienes, will be discussed. A panel of international experts will provide the latest innovations in medical and surgical treatments through a case‐based approach of difficult patients and strategies for success illustrating these advancements. Educational Objectives: 1) Interpret current theories on the pathogenesis of nasal polyposis. 2) Recognize the newest medical and surgical treatments for difficult nasal polyposis, including cystic fibrosis. 3) Initiate additional therapeutic measures to appropriately care for patients with severe nasal polyposis.
Working with objects. The OOram Software Engineering Method. (2020)

Book. Manning/Prentice Hall 1996. ISBN 0-13-452930-8. Distributed by Prentice-Hall for a few months, they then withdrew it from the market without any explanation. Very frustrating. Out of print, copyright has reverted to the author. This dataset is the last draft before publication. Working with objects is the source on a method which takes an evolutionary step forward in object-oriented development practices. OOram adds the intuitively simple but powerful concept of a role to object-oriented models and methods. For example, imagine trying to describe a person as an object. The most effective way to do this would be to independently describe each of the roles that person adopts (parent, employee, and so on) and then define how the person supports them. These ideas form the heart of the OOram approach. 2 reviews: "The first method that deals realistically with reuse, and one of the few that comes close to describing what I do when I design." (Ralph Johnson, University of Illinois) Ian Graham voted this book "One of the Three Best Books" of 1996/97. (JOOP September 97): "This book brings the OOram method before the public, along with its most significant contribution to object-oriented software engineering: role modeling. It also provides plenty of sensible advice for developers adopting object technology, based on the author's evident experience and understanding of the the technical intricacies and human aspects of software development. However, it is a deeply technical book and will put off readers who are not already familiar with an object-oriented programming language."... "As a technical contribution it should become one of the classic texts within the field. The role modeling ideas will undoubtedly influence other object-oriented software engineering methods and I think we will see them quickly adopted in the now emerging third generation methods."
[Incorporation of neoglycolipids into K562 cells. Model for the study of carbohydrate dependent lysis of target cells by natural killer cells]. (1998)

A model system was developed to study the role of cell surface oligosaccharides in cytotoxicity mediated by natural killer (NK) cells. Polymeric glycoconjugates Glyc-PAA-PE and Glyc-PAA(Flu)-PE (where Glyc is the 3-aminopropyl Le(x) residue, PAA is the poly(N-2-hydroxyethylacrylamide) matrix, Flu is the residue of a fluorescein derivative, and PE is the phosphatidylethanolamine residue) were synthesized, and their association with the membranes of living K562 cells was studied.
Magnetostrictive materials and method for improving AC characteristics in same (2001)

The present invention provides Terfenol-D alloys (“doped” Terfenol) having optimized performances under the condition of time-dependent magnetic fields. In one embodiment, performance is optimized by lowering the conductivity of Terfenol, thereby improving the frequency response. This can be achieved through addition of Group III or IV elements, such as Si and Al. Addition of these types of elements provides scattering sites for conduction electrons, thereby increasing resistivity by 125% which leads to an average increase in penetration depth of 80% at 1 kHz and an increase in energy conversion efficiency of 55%. The permeability of doped Terfenol remains constant over a wider frequency range as compared with undoped Terfenol. These results demonstrate that adding impurities, such as Si and Al, are effective in improving the ac characteristics of Terfenol. A magnetoelastic Grüneisen parameter, γme, has also been derived from the thermodynamic equations of state, and provides another means by which to characterize the coupling efficiency in magnetostrictive materials on a more fundamental basis.
Fijación de la tasa de corte en la evaluación de proyectos de inversión: un análisis desde el desarrollo empresario (2007)

Nontuberculous mycobacteria (NTM) have been recognized as an important cause of disease in immunocompromised hosts. Pulmonary disease caused by NTM is increasingly recognized in previously healthy persons. Investigation of pulmonary disease affecting a family of five identified an indoor hot tub as the source of NTM-related disease.
Special Sensor Microwave/Imager (SSM/I) Observations of Hurricane Hugo (1989) (1992)

Data from the Special Sensor Microwave/Imager (SSM/I) on board a Defense Meteorological Satellite Program (DMSP) spacecraft have been used to study the precipitation patterns associated with Hurricane Hugo (1989). Results indicate the intensification of Hugo was associated with increases in SSM/I-derived total latent heat release and increases in heavier rainfall rates near the storm center. This study also shows that SSM/I rainfall rates prior to the landfall of Hugo at Charleston, South Carolina, compared favorably with raingage observations. Additionally, data from the 85-GHz channel was used to monitor the extent of convection near the storm's center. As Hugo intensified, the areal coverage of deep convection increased. Furthermore, the 85-GHz brightness-temperature imagery was useful in determining the location of Hugo's low-level center. These results indicate the potential of using SSM/I data in the analysis and prediction of tropical cyclones in an operational environment.
Matrix analysis and applied linear algebra (2001)

Preface 1. Linear equations 2. Rectangular systems and echelon forms 3. Matrix algebra 4. Vector spaces 5. Norms, inner products, and orthogonality 6. Determinants 7. Eigenvalues and Eigenvectors 8. Perron-Frobenius theory of nonnegative matrices Index.
Clinical, Microbiological, and Immunological Characteristics in HIV-Infected Subjects at Risk for Disseminated Mycobacterium avium Complex Disease: An AACTG Study (2005)

The clinical, microbiologic, and immunologic parameters in HIV-infected subjects first presenting with disseminated Mycobacterium avium complex (DMAC) were determined. Four HIV-positive groups not yet on DMAC treatment were enrolled: 19 subjects with CD4 lymphocyte counts < or =50/microl thought to have DMAC on clinical grounds; 18 subjects newly found to have a positive blood culture for MAC; 25 asymptomatic controls (CD4 cell counts < or =50); and 25 asymptomatic controls (CD4 counts 100-250/microl). Outcome measures include comparisons between groups for clinical characteristics; results of cultures from blood, marrow, and gastrointestinal and respiratory tracts; immunological markers from staining of marrow and flow cytometry of circulating lymphocytes; and cytokine production of PBMCs. Only 21% of the 19 patients entered on suspicion of having DMAC grew MAC from blood or marrow. Neither clinical presentation nor laboratory tests differentiated those culture-positive from those culture-negative patients. However, prior PCP or multiple other opportunistic infections were more common in the DMAC group. MAC was isolated from 82% of marrow and 50% of blood specimens from the DMAC group. Respiratory or gastrointestinal colonization was present in 36% of DMAC subjects, but only 5% of non-DMAC subjects with CD4 counts <50 cells/microl. CD8+ cells were more frequent in bone marrow, and CD4 cells recognizing MAC antigen were more frequent in blood from DMAC subjects vs. controls. Results suggest an early stage of tissue dissemination preceding persistent bacteremia, and mucosal entry without persistence of colonization. MAC-specific T cell responses apparently develop and persist during DMAC, but are dysfunctional or too infrequent to prevent persistence.
Accelerating Applications of Metal–Organic Frameworks for Gas Adsorption and Separation by Computational Screening of Materials (2012)

The selection of metal-organic frameworks (MOFs) for gas adsorption and separation has become a significant challenge over the past decade because of the large number of new structures reported every year. We applied a multiscale computational approach to screen existing MOFs for CO(2)/N(2) separation. Pore characteristics of 1163 MOFs were analyzed by the method developed by Haldoupis, Nair, and Sholl (Haldoupis, E.; Nair, S.; Sholl, D. S. J. Am. Chem. Soc.2010, 132, 7528) using a simple steric model. On the basis of the pore size analysis, 359 MOFs were examined by classical molecular simulations. Adsorption and diffusion properties were computed using grand canonical Monte Carlo (GCMC) and molecular dynamics (MD) simulations, respectively. These molecular simulations were used to assess which materials hold the greatest promise as membrane materials for CO(2)/N(2) separations. Finally, density functional theory (DFT) calculations were performed to provide preliminary information on the dynamic framework motion of selected MOFs.
Performance Evaluation of 1.5 kV Solar Inverter With 2.5 kV Silicon Carbide mosfet (2019)

1.5 kV dc link voltage has been a trend for the solar industry. Moving from 1 to 1.5 kV dc voltage can increase string length, enhance inverter conversion ability, increase array block sizes, and improve performance. Multilevel converters are the natural choices while control becomes more complicated. If a simple two-level converter is adopted, the 1.7 kV device may not be applicable considering the voltage derating for certain failure rate. Therefore, devices with higher blocking voltage should be considered. This paper reports for the first time the performance characterization of a 2.5 kV silicon carbide (SiC) mosfet. The potential application of this device for 1.5 kV solar inverter is also evaluated compared to the solutions with a 1.2 kV device.
Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation‐related protein (ADRP) (2010)

Hepatic stellate cells (HSCs) store retinoids and triacylglycerols in cytoplasmic lipid droplets. Two prominent features of HSC activation in liver fibrosis are loss of lipid droplets along with increase of alpha-smooth muscle actin (alpha-SMA), but the link between these responses and HSC activation remains elusive. In non-adipose cells, adipose differentiation-related protein (ADRP) coats lipid droplets and regulates their formation and lipolysis; however its function in HSCs is unknown. Here, we observed, in human liver sections or primary HSC culture, ADRP localization to lipid droplets of HSCs, and reduced staining coincident with loss of lipid droplets in liver fibrosis and in culture-activated HSCs, consistent with HSC activation. In the LX-2 human immortalized HSCs, with scant lipid droplets and features of activated HSCs, we found that the upregulation of ADRP mRNA by palmitate is potentiated by retinol, accompanied by increased ADRP protein, generation of retinyl palmitate, and lipid droplet formation. ADRP induction also led to decreased expression of alpha-SMA mRNA and its protein, while ADRP knockdown with small interfering RNA (siRNA) normalized alpha-SMA expression. Furthermore, ADRP induction by retinol and palmitate resulted in decreased expression of collagen I and matrix metalloproteinase-2 mRNA, fibrogenic genes associated with activated HSCs, while increasing matrix metalloproteinase-1 mRNA; ADRP knockdown with siRNA reversed these changes. Tissue inhibitor of metalloproteinase-1 was not affected. Thus, ADRP upregulation mediated by retinol and palmitate promotes downregulation of HSC activation and is functionally linked to the expression of fibrogenic genes.
Electric Field Measurements In Photoconductive GaAs Switches (2005)

The Frum-Keldysh effect has been used to measure the electric field distribution in a photoconductive gallium arsenide switch. The results indicate the build-up of electric fields at the anode during lock-on and subsequent dielectric breakdown leading to current filamentation. The diagnostic technique, which has a temporal resolution given by the probe laser, can be extended to provide information on the carrier density distribution and the temperature distribution in the gallium arsenide switch.
Generation of growl-type voice qualities by spectral morphing (2013)

In this paper we introduce a morph-based approach for generating voice source aperiodicities frequently associated with strong vocal expressions, especially in singing. In our approach the excitation characteristics of one signal are combined the fundamental frequency and spectral envelope characteristics of another signal. An exemplar sustained sample of the target voice quality is looped and resampled in the time domain in order to generate a continuous signal matching the input voice's fundamental frequency. This operation preserves most of the sample's voice quality characteristics at the cost of scaling time and frequency dimensions. While we found the temporal scaling to be acceptable in many contexts, the frequency scaling has to be inverted in order to generate appropriate spectral content for the source excitation's entire bandwidth. This can be accomplished by the phase-locked vocoder method of modulating harmonic bands in frequency. Finally, the input signal's harmonic amplitudes and phases are applied to the transformed morph sample, allowing for a simple one-dimensional control of morph amount by linear interpolation with the input signal. The proposed system is evaluated and the results are discussed.
Scanning the Earth's Limb from a High-Altitude Balloon: The Development and Flight of a New Balloon-Based Pointing System (2002)

The development and first flight of a new balloon-borne pointing system is discussed. The system is capable of pointing a platform of optical instruments at an inertial target from a pendulating platform suspended below a high-altitude balloon. It operates in both a traditional occultation-scan mode, to observe solar absorption, and a limb-scan mode, to make measurements of Earth's limb. The system employs integrated sensors and high-level icon-based software (Labview). A microprocessor controller derives real-time estimates of gondola attitude, employing an extended Kalman filter to combine gyro, magnetometer, tilt-sensor, and shaft-encoder information. These estimates are used to develop control demands that point a platform of instruments in elevation and azimuth. The system's first flight was from Vanscoy, Saskatchewan, Canada, on 29 August 2000. Results of the system's performance during this mission are presented. In flight, the system demonstrated a pointing accuracy better than 0.1° (1σ) in elevation and 3° (1σ) in azimuth.
Chemical Analysis of Deposits Separated from Blocked Fuel Filters (2021)

&lt;div&gt;Biodiesel was found to be the best candidate to replace diesel fuel mainly due to being renewable, biodegradable, and non-toxic and reduce greenhouse gases, which cause global warming. Nowadays, biodiesel is blended with diesel fuel in different concentrations depending on the country of usage and is used in diesel engines. Concerns about biodiesel were raised after premature fouling of fuel filters were reported before meeting their mileage requirement. Three filters from Brazil were analyzed using different techniques (Energy Dispersive X-Ray [EDX], Fourier Transform Infrared Spectroscopy [FTIR], Thermogravimetric Analysis [TGA], Time of Flight-Secondary Ion Mass Spectrometry [ToF-SIMS], and Gas Chromatography/Mass Spectrometry [GC/MS]) to understand the chemical composition of the filter deposits and highlight the main compounds responsible for the blockage. EDX showed that the deposits are mainly composed of carbon (C) and oxygen (O) with traces of sodium (Na), calcium (Ca), iron (Fe), phosphorus (P), and other elements. FTIR showed that the dominant bands in the filter deposits spectra are attributed to C-O bonds with a broad OH peak always present. TGA showed that the deposits vaporize at three different regions with peak temperatures around 250°C, 350°C, and 480°C, which correspond to the vaporization of glycerol, sterol glucosides (SGs), and metal carboxylates, respectively. Combining the data from the previous techniques, it was concluded that the filter deposits are mainly organic in nature with glycerol and SGs as the main compounds forming the bulk of the filter deposits with metal carboxylates present in lower amounts. This conclusion was further confirmed by ToF-SIMS and GC/MS where all three compounds were detected. In addition, free sterols and monoglycerides (MGs) were also detected in the deposits with traces of diglycerides and triglycerides also present.&lt;/div&gt;
Bartonella kosoyi sp. nov. and Bartonella krasnovii sp. nov., two novel species closely related to the zoonotic Bartonella elizabethae, isolated from black rats and wild desert rodent-fleas (2020)

The genus <i>Bartonella</i> (Family: <i>Bartonellaceae</i>; Order: <i>Rhizobiales;</i> Class: Alphaproteobacteria) comprises facultative intracellular Gram-negative, haemotropic, slow-growing, vector-borne bacteria. Wild rodents and their fleas harbor a great diversity of species and strains of the genus <i>Bartonella</i>, including several zoonotic ones. This genetic diversity coupled with a fastidious nature of the organism results in a taxonomic challenge that has led to a massive collection of uncharacterized strains. Here, we report the genomic and phenotypic characterization of two strains, members of the genus <i>Bartonella</i> (namely Tel Aviv and OE 1-1), isolated from <i>Rattus rattus</i> rats and <i>Synosternus cleopatrae</i> fleas, respectively. Scanning electron microscopy revealed rod-shaped bacteria with polar pili, lengths ranging from 1.0 to 2.0 µm and widths ranging from 0.3 to 0.6 µm. OE 1-1 and Tel Aviv strains contained one single chromosome of 2.16 and 2.23 Mbp and one plasmid of 29.0 and 41.5 Kbp, with average DNA G+C contents of 38.16 and 38.47 mol%, respectively. These strains presented an average nucleotide identity (ANI) of 89.9 %. <i>Bartonella elizabethae</i> was found to be the closest phylogenetic relative of both strains (ANI=90.9-93.6 %). The major fatty acids identified in both strains were C<sub>18:1</sub>ω7<i>c</i>, C<sub>18 : 0</sub> and C<sub>16 : 0</sub>. They differ from <i>B. elizabethae</i> in their C<sub>17 : 0</sub> and C<sub>15 : 0</sub> compositions. Both strains are strictly capnophilic and their biochemical profiles resembled those of species of the genus <i>Bartonella</i> with validly published names, whereas differences in arylamidase activities partially assisted in their speciation. Genomic and phenotypic differences demonstrate that OE 1-1 and Tel Aviv strains represent novel individual species, closely related to <i>B. elizabethae</i>, for which we propose the names <i>Bartonella kosoyi</i> sp. nov. and <i>Bartonella krasnovii</i> sp. nov.
Antiquarische Bücher als Senke luftgetragener Schadstoffe (1999)

Abstract Warum zerfallen alte Bücher und Urkunden? Umweltfaktoren spielen eine Rolle, doch welche Bedeutung kommt historischen Lagerbedingungen zu? Die Cellulose alter Bücher fungiert in der Tat als Schadstoffsenke: Über längere Zeiträume hinweg werden Stickstoff‐ und Schwefeloxide sowie Chlorwasserstoff aus der Atmosphäre eingetragen.