gebhart/patrepeval huggingface dataset:
Local Editing of Cross-Surface Mappings with Iterative Least Squares Conformal Maps (2020)

In this paper, we propose a novel approach to improve a given surface mapping through local refinement. The approach receives an established mapping between two surfaces and follows four phases: (i) inspection of the mapping and creation of a sparse set of landmarks in mismatching regions; (ii) segmentation with a low-distortion region-growing process based on flattening the segmented parts; (iii) optimization of the deformation of segmented parts to align the landmarks in the planar parameterization domain; and (iv) aggregation of the mappings from segments to update the surface mapping. In addition, we propose a new approach to deform the mesh in order to meet constraints (in our case, the landmark alignment of phase (iii)). We incrementally adjust the cotangent weights for the constraints and apply the deformation in a fashion that guarantees that the deformed mesh will be free of flipped faces and will have low conformal distortion. Our new deformation approach, Iterative Least Squares Conformal Mapping (ILSCM), outperforms other low-distortion deformation methods. The approach is general, and we tested it by improving the mappings from different existing surface mapping methods. We also tested its effectiveness by editing the mappings for a variety of 3D objects.
Developmental Regulation of Pyrroline-5-Carboxylate Reductase Gene Expression in Arabidopsis (1997)

At-P5R, a gene encoding the last enzyme of the proline (Pro) biosynthetic pathway in Arabidopsis thaliana, is developmentally regulated. To characterize the cis elements responsible for this developmental regulation, a series of 5' deletions of the At-P5R promoter were transcriptionally fused to a beta-glucuronidase (GUS)-coding region and transformed into Arabidopsis. The complete promoter of At-P5R directs strong GUS activity in root tips, the shoot meristem, guard cells, hydathodes, pollen grains, ovules, and developing seeds, all of which contain rapidly dividing cells and/or are undergoing changes in osmotic potential. This expression pattern is consistent with the function of Pro as an energy, nitrogen, and carbon source and as an osmoticum in response to dehydration. Promoters longer than 212 base pairs (bp) showed the same expression pattern, whereas those shorter than 143 bp did not direct any detectable GUS activity in any organs. This suggests that a 69-bp promoter region located between -212 and -143 bp is necessary to establish the tissue-specific expression of At-P5R during development. The Pro content measured in different organs suggests that, in addition to transcriptional control of the biosynthetic pathway, the transport of Pro may play a role in its distribution within Arabidopsis. Several aspects of the relationship between Pro metabolism and plant physiology are discussed.
Direct modulation of osteoblastic activity with estrogen. (1994)

Estrogens play an important but poorly understood role in the maintenance of skeletal mass. Whereas the mechanisms of estrogen action on bone may be complex, the finding that osteoblasts express estrogen receptors suggests that this class of hormones exerts direct effects on bone cells. To understand how estrogens regulate osteoblastic function, the physiologically active estrogen metabolite 17 beta-estradiol was tested to determine its effects on the well characterized murine osteoblastic cell-line MC3T3-E1. Experiments were designed to identify the effects of estrogen on osteoblastic activities associated with both the formation and the resorption of bone. Estrogen treatment coordinately increased DNA content and alkaline phosphatase activity in MC3T3-E1 cells as much as twofold. The stimulatory effect on alkaline phosphatase was stereospecific, dose-dependent between 0.1 and ten nanomolar, and dependent on the time in culture when the hormone was administered. The effect was also persistent, since alkaline phosphatase activity remained elevated for several days after withdrawal of the hormone. Estrogen increased the levels of messenger RNA for alkaline phosphatase and type-I collagen as well, and these effects also persisted after removal of the hormone. The levels of messenger RNA for osteopontin, another bone-matrix protein, were only slightly affected by estrogen. Finally, estrogen inhibited the activation of adenylate cyclase by three osteotropic agents known to stimulate the resorption of bone: parathyroid hormone, prostaglandin E2, and the beta-adrenergic agonist isoproterenol. Thus, estrogen promoted the expression of traits associated with the formation of bone while reducing cellular responsiveness to hormones that may trigger the resorption of bone.(ABSTRACT TRUNCATED AT 250 WORDS)
Working as a contact center attendant: Relating purpose, meaning, sustainability and mental health (2023)

The discussion proposes that work-related sciences, such as ergonomics and psychodynamics of work, can bring another type of rationality to the decision-making processes of companies. The work also needs to be sustainable enough to allow the construction and development of professionals, and the health of working population, while improving the company's performance.
High-rate DFT-based data manipulator (HDDM) algorithm for effective interference mitigation (2020)

Interferences to global navigation satellite system (GNSS) signals are a significant threat to navigation security and reliability. Therefore, there is a continuous need to improve the robustness of receivers through the use of adequate interference mitigation methods. This paper presents the high-rate DFT-based data manipulator (HDDM) algorithm as a robust and efficient interference mitigation method. This method uses a discrete Fourier transform (DFT) to transform the signal to the Fourier domain, to remove strong signal components before transforming back to the time domain. What distinguishes this algorithm from many similar mitigation methods, that also deploy a DFT, is that the DFT is calculated for every sample delay. Thereby highly over-sampling the signal, which allows mitigation to remove an interference without causing distortion effects. Results have shown that the HDDM can potentially provide superior interference mitigation capabilities against frequency-modulated continuous-wave (FMCW) signals, compared to other commonly used mitigation algorithms. Further, the algorithm is suitable for hardware implementations, due to relatively low latency, low memory, and low tuning requirements. The HDDM is an improvement on other multi-spectral techniques, and allows robust and reliable interference removal.
Product Study of the OH, NO3, and O3Initiated Atmospheric Photooxidation of Propyl Vinyl Ether (2006)

A product study is reported on the gas-phase reactions of OH and NO3 radicals and ozone with propyl vinyl ether (PVE). The experiments were performed in a 405 L borosilicate glass chamber in synthetic air at 298 +/- 3 K using long path in situ FTIR spectroscopy for the analysis of the reactants and products. In the presence of NO(x) (NO + NO2) the main products for the OH-radical initiated oxidation of PVE were propylformate and formaldehyde with molar formation yields of 78.6 +/- 8.8% and 75.9 +/- 8.4%, respectively. In the absence of NO(x) propylformate and formaldehyde were formed with molar formation yields of 63.0 +/- 9.0% and 61.3 +/- 6.3%, respectively. In the reaction of NO3 radicals with PVE propylformate 52.7 +/- 5.9% and formaldehyde 55.0 +/- 6.3% were again observed as major products. The ozonolysis of PVE led to the production of propylformate, formaldehyde, hydroxyperoxymethyl formate (HPMF; HC(O)OCH2OOH), and CO with molar formation yields of 89.0 +/- 11.4%, 12.9 +/- 4.0%, 13.0 +/- 3.4%, and 10.9 +/- 2.6%, respectively. The formation yield of OH radicals in the ozonolysis of PVE was estimated to be 17 +/- 9%. Simple atmospheric degradation mechanisms are postulated to explain the formation of the observed products.
Efficient Synthesis of Optically Active Atropisomeric Anilides through Catalytic Asymmetric N-Arylation Reaction (2005)

In the presence of (R)-DTBM-SEGPHOS-Pd(OAc)2 catalyst, N-arylation of ortho-tert-butyl-NH-anilides with 4-nitroiodobenzene proceeds with high enantioselectivity (89-95% ee) to give optically active atropisomeric anilides possessing N-C chiral axis. Furthermore, the intramolecular version of the present catalytic asymmetric N-arylation gave atropisomeric lactams with high optical purity (94-96% ee).
Evaluierung von Merkmalen zur Abbildung von Veränderungen in ungeordneten Bilddaten (2021)

Zusammenfassung Durch das Aufkommen von kostengünstigen und mobilen Kameras ist es möglich, einfach und flächendeckend ungeordnete Bilddaten in großem Umfang zu erheben. Dadurch können Veränderungen von Gebieten bzw. Objekten aufgezeichnet werden. Die Abbildung von objektbezogenen Veränderungen in aufgezeichneten Bildaufnahmen ist jedoch eine Herausforderung, da diese von externen oder szenischen Veränderungen überlagert werden können. Insbesondere der Umgang mit stark variierenden Blickwinkeln ist eine aktuelle Forschungsfrage. In dieser Arbeit wird ein allgemeines Vorgehen zur Repräsentation von Objektveränderungen vorgestellt. Es wird ein Datensatz eingeführt, um den Ansatz auf Realdaten zu evaluieren. In diesem Zusammenhang werden unterschiedliche Konfigurationen getestet und im Nachgang Empfehlungen für eine effektive Parametrierung herausgearbeitet. Im Anschluss wird als Anwendung eine Klassifikation von Objektzuständen vorgestellt.
Effects of Pyributicarb on Squalene Metabolism in Corn and Soybean. (1993)

6-methoxy-2-pyridyl(methyl)thiocarbamate] and its effects on lipid biosynthesis were investigated using corn (Zea mays L. cv.
Oncogenic activity of SOX1 in glioblastoma (2017)

Glioblastoma remains the most common and deadliest type of brain tumor and contains a population of self-renewing, highly tumorigenic glioma stem cells (GSCs), which contributes to tumor initiation and treatment resistance. Developmental programs participating in tissue development and homeostasis re-emerge in GSCs, supporting the development and progression of glioblastoma. SOX1 plays an important role in neural development and neural progenitor pool maintenance. Its impact on glioblastoma remains largely unknown. In this study, we have found that high levels of SOX1 observed in a subset of patients correlate with lower overall survival. At the cellular level, SOX1 expression is elevated in patient-derived GSCs and it is also higher in oncosphere culture compared to differentiation conditions in conventional glioblastoma cell lines. Moreover, genetic inhibition of SOX1 in patient-derived GSCs and conventional cell lines decreases self-renewal and proliferative capacity in vitro and tumor initiation and growth in vivo. Contrarily, SOX1 over-expression moderately promotes self-renewal and proliferation in GSCs. These functions seem to be independent of its activity as Wnt/β-catenin signaling regulator. In summary, these results identify a functional role for SOX1 in regulating glioma cell heterogeneity and plasticity, and suggest SOX1 as a potential target in the GSC population in glioblastoma.
The Role of Static Charge in Ultra-Low Alpha Particle Emissivity Measurements (2015)

Electrically-insulating samples placed on the grounded sample tray in ionization detectors perturb the electric field within the detector. The resulting alpha particle emissivity of the samples is reduced depending on the magnitude and polarity of the surface voltage. Data are shown for samples with positive and negative surface charge, as well as methods to both measure and eliminate the effects of the surface charge.
Multi-Energy Metabolic Mechanisms of the FungusFusarium oxysporumin Low Oxygen Environments (2010)

The fungus Fusarium oxysporum produces energy under hypoxic and anoxic conditions by denitrification (nitrate respiration) and ammonia fermentation respectively. Here we found that glucose repressed both of these metabolisms, whereas it supported another anoxic metabolism, hetero-lactic acid fermentation. Ammonia fermentation occurred only after the glucose present in the medium was metabolized to ethanol via alcohol fermentation. During this transition, clear diauxic growth was observed. Glucose regulated the activity of the enzymes involved in ammonia fermentation, hetero-lactic acid fermentation, and denitrification. Highest cell growth was supported by hetero-lactic acid fermentation, followed by denitrification and ammonia fermentation. These results indicate that the energy metabolisms of F. oxysporum are dependent not only on environmental O(2) tension but also on the carbon source, and that ammonia fermentation is an adaptative mechanism acting physiologically as a secondary fermentative mechanism replacing the primary hetero-lactic acid fermentation.
Router supported data regeneration protocols in distributed storage systems (2011)

Distributed storage systems provide reliable data storage by keeping redundancy over a large number of storage nodes in the network. Due to the large number of storage nodes, they can not be regarded as always available. Compared with replications, erasure codes can achieve higher data integrity, such that any k among n storage nodes can recover the original data. Moreover, in order to maintain a consistent degree of redundancy, it is necessary to regenerate new data in a replacement node after a node failure. However, erasure codes require k blocks to be transmitted from other storage nodes to generate a new block, resulting in a high volume of network traffic and a significant bandwidth bottleneck in the network. In this paper, we present a novel idea that we can both save the traffic and time consumed during the regeneration with the support of routers. With the enhanced computing ability, some reconstruction operations in the regeneration process can be performed by supporting routers rather than by the replacement node solely. We also design two router supported data regeneration protocols that make supporting routers provide support transparently to storage nodes and utilize the bandwidth diversity in the network, respectively. Simulation results show that with the help of supporting routers and our protocols, the traffic and time spent during the regeneration can be both reduced significantly.
The Quality of Die-Attachment and Its Relationship to Stresses and Vertical Die-Cracking (1983)

The residual stresses after die-attachment have been studied experimentally using a test chip with diffused resistor strain gauges. Extensive measurements are reported for the following dieattachment/leadframe combinations: Au-Si/Alloy 42, epoxy adhesive/ Copper 194, and polyimide adhesive/Copper 194. Two-dimensional distributions of the stresses in the device surface are shown, and additional thickness measurements of the adhesive layer are used to assess the amount of stress relaxation occuring in adhesive die-attachment. Large variations in the measured stresses were found for die-attachment with polyimide adhesive. Thickness measurements and radiography showed that the stress variations are caused by large voids formed during the drying cycle of the adhesive. The effect of voids on die-attachment stresses is analyzed, and its potential as a cause of vertical die-cracking is discussed.
Application of Twisted Retarders to a Cholesteric Liquid Crystal Polarizer for the Control of Output Polarization States (2009)

The possibility of applying twisted retarders to a cholesteric liquid crystal polarizer for the control of polarization states has been investigated. In particular, we have focused on the application of twisted retarders to the conversion of circular polarization states into linear polarization states. It has been found that circular polarization states could be converted into arbitrary linear polarization states using twisted retarders. We have fabricated left-handed twisted retarder films using commercially available liquid crystals. Their optical characteristics were experimentally investigated and found to be in good agreement with theoretical expectations.
A New Type of Non-Kekulé Diradicals with Triplet Ground States. I. Polymethine Systems (2006)

Abstract It is shown theoretically that the ground state of a new class of non-Kekulé polymethine molecules can be a triplet state with non-degenerate singly occupied MOs. The investigated polymethine cyanine cations, polymethine oxonol anions, and neutral polymethine merocyanines are derivatives of the stable 2-azaphenalenyl radical whose pentamethine fragment is part of the polymethine chain.
Photoelectrochemical Characterization of Sprayed α‐Fe2O3 Thin Films: Influence of Si Doping and SnO2 Interfacial Layer (2008)

α ‐Fe 2 O 3 thin film photoanodes for solar water splitting were prepared by spray pyrolysis of Fe(AcAc) 3 . The donor density in the Fe 2 O 3 films could be tuned between 10 17 –10 20 cm −3 by doping with silicon. By depositing a 5 nm SnO 2 interfacial layer between the Fe 2 O 3 films and the transparent conducting substrates, both the reproducibility and the photocurrent can be enhanced. The effects of Si doping and the presence of the SnO 2 interfacial layer were systematically studied. The highest photoresponse is obtained for Fe 2 O 3 doped with 0.2% Si, resulting in a photocurrent of 0.37 mA/cm 2 at 1.23 V RHE in a 1.0 M KOH solution under 80 mW/cm 2 AM1.5 illumination.
The Interpretation of Marker Experiment Conducted during Formation of Higher Oxide on the Surface of Lower Oxide (2015)

The marker method in studying the formation mechanism and defect structure of higher oxide during oxidation of lower oxide has been discussed. The approach to this problem needs specific treatment, both in experimental procedure and in the interpretation of results. It has been shown that the correct results of marker experiments in the case of highly defected substrates can be obtained, if these substrates before the marker deposition process are submitted to homogenization under highest oxidant activity, at which they remain stable at a given temperature. In addition, the nonstoichiometry must be considered in formulating appropriate chemical reactions, being the basis for foreseeing the location of markers in the interior of reaction product. The other very important problem consists in the possibility of the formation of reaction product not only on the surface of oxidized substrate but also inside of this substrate. In such a situation, the formulation of final conclusions concerning the crystalline lattice disorder from marker position should be combined with considerations of chemical reactions and transport processes occurring in a given substrate.
Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation (2001)

Human telomerase, a cellular reverse transcriptase (hTERT), is a nuclear ribonucleoprotein enzyme complex that catalyzes the synthesis and extension of telomeric DNA. This enzyme is specifically activated in most malignant tumors but is usually inactive in normal somatic cells, suggesting that telomerase plays an important role in cellular immortalization and tumorigenesis. Terminal maturation of tumor cells has been associated with the repression of telomerase activity. Using maturation-sensitive and -resistant NB4 cell lines, we analyzed the pattern of telomerase expression during the therapeutic treatment of acute promyelocytic leukemia (APL) by retinoids. Two pathways leading to the down-regulation of hTERT and telomerase activity were identified. The first pathway results in a rapid down-regulation of telomerase that is associated with retinoic acid receptor (RAR)-dependent maturation of NB4 cells. Furthermore, during NB4 cell maturation, obtained independently of RAR by retinoic X receptor (RXR)-specific agonists (rexinoids), no change in telomerase activity was observed, suggesting that hTERT regulation requires a specific signaling and occurs autonomously. A second pathway of hTERT regulation, identified in the RAR-responsive, maturation-resistant NB4-R1 cell line, results in a down-regulation of telomerase that develops slowly during two weeks of all-trans retinoic acid (ATRA) treatment. This pathway leads to telomere shortening, growth arrest, and cell death, all events that are overcome by ectopic expression of hTERT. These findings demonstrate a clear and full dissociation between the process of tumor cell maturation and the regulation of hTERT mRNA expression and telomerase activity by retinoids. We propose telomerase expression as an efficient and selective target of retinoids in the therapy of tumors.
Inhibition of radiation-induced nuclear factor-kappaB activation by an anti-Ras single-chain antibody fragment: lack of involvement in radiosensitization. (2002)

We have shown previously that the transduction of a number of human tumor cell lines with an adenovirus (AV1Y28) expressing a single-chain antibody fragment (scFv) directed against Ras proteins results in radiosensitization. Because Ras is involved in the regulation of a number of transcription factors, we have determined the effects of this adenovirus on the activation of nuclear factor-kappaB (NF-kappaB), a radiation-responsive transcription factor associated with cell survival. In U251 human glioma cells, radiation-induced NF-kappaB was significantly attenuated by prior transduction of the anti-Ras scFv adenovirus. This effect appeared to involve an inhibition of IkappaB kinase activity and IkappaBalpha phosphorylation. Inhibitors to the Ras effectors mitogen-activated protein kinase kinase, phosphatidylinositol 3-kinase, and p38, however, did not reduce radiation-induced NF-kappaB. Whereas AV1Y28 inhibited NF-kappaB activation by hydrogen peroxide and ferricyanide, it had no effect of tumor necrosis factor-alpha-induced NF-kappaB activation. These results are consistent with a novel Ras-dependent, oxidant-specific signaling pathway mediating the activation of NF-kappaB. In additional cell lines radiosensitized by AV1Y28, radiation-induced NF-kappaB activation was also inhibited by the anti-Ras scFv, whereas in cell lines not radiosensitized, radiation did not activate NF-kappaB. This correlation suggested that AV1Y28-mediated radiosensitization involved the inhibition of radiation-induced NF-kappaB activation. However, inhibition of NF-kappaB activation via the expression of a dominant-negative form of IkappaBalpha in U251 cells had no effect on radiation-induced cell killing and did not influence AV1Y28-mediated radiosensitization. Therefore, whereas AV1Y28 inhibits radiation-induced NF-kappaB activation, this process does not appear to play a direct role in its radiosensitizing actions.
MUSE: a software oscilloscope for clusters and grids (2004)

Oscilloscopes and their cousins, logic analyzers, are the tools of choice for difficult electronic hardware problems. In the hands of a skilled engineer or technician, these tools can be used to solve stubborn problems. The key to the utility of oscilloscopes is the depth of detail they provide and their flexibility, which allows the level of detail to be adjusted to fit the task at hand. Distributed applications, which run on computing clusters and computational grids, are also complex and difficult to tame. We need tools to understand their complexities and the ability to choose the level of detail to fit the task, whether the task be debugging, tuning, monitoring or controlling. The MAGNET User-Space Environment (MUSE) has been designed as a "software oscilloscope" for computing clusters and computational grids. It is a toolkit for applications and developers to obtain detailed information about the environment on the host. The information can be used on-line or saved for off-line analysis. It has low overhead and allows the level of detail to be adjusted. Furthermore, MUSE monitors without requiring the modification or relinking of applications. It has been designed to make it easy to develop "adaptive applications" - applications that are aware of their environment and can adapt to changes.