gebhart/patrepeval huggingface dataset:
Regional myocardial hybernation detected by low-dose dobutamine stress MRI in minipigs with prolonged left ventricular dyssynchronous contraction (2008)

Purpose: Neuregulin-1 (NRG-1) is a paracrine growth factor released from endothelial cells in the heart. It stimulates ErbB2 and ErbB4 receptors on cardiomyocytes. Paracrine NRG-1 signalling in the myocardium is activated after exposure to anthracyclines and protects against the development of toxic cardiomyopathy. Conversely, inhibition of NRG-1 signalling after administration of trastuzumab, a monoclonal anti-ErbB2 antibody, exacerbates anthracycline-induced left ventricular (LV) dysfunction. The role of NRG-1 and ErbB activation in other forms of LV dysfunction is still incompletely understood. In this study, we hypothesized that myocardial NRG-1/ErbB signalling is activated during overdrive pacing-induced heart failure. Methods: Nineteen male beagle dogs with pacing-induced heart failure (HF) over 4 to 7 weeks underwent weekly echocardiograms and endomyocardial biopsies. Relative mRNA expression of target genes was measured with real-time RT-PCR. Phosphorylated ErbB2 and ErbB4 were measured by immunoprecipitation and Western blotting after sacrifice in 6 normal dogs, in 6 dogs with moderate HF (4 weeks of pacing) and in 7 dogs with overt congestive HF (7 weeks of pacing). Results: Rapid right ventricular pacing increased LV end-diastolic volume (64±4.3 ml/m2 at baseline and 113±7.2 ml/m2 at week 7, p<0.001) and decreased LV ejection fraction (67±1.6% at baseline and 37±2.6% at week 7, p<0.001). Over the same time course, ventricular NRG-1 mRNA expression increased 4-fold (p<0.01) and expression of a proteolytic enzyme promoting NRG-1 release, ADAM19, increased 2-fold (p<0.05). Left ventricular ErbB2 and ErbB4 receptors showed increasing degrees of overall and site-specific tyrosine phosphorylation over time. ErbB2 receptors underwent truncation exclusively in myocardium of dogs with moderate and severe HF, leading to the formation of a 95 kDa membrane-bound receptor remnant. Conclusions: Pacing-induced cardiomyopathy is accompanied by activation of myocardial NRG-1/ErbB signalling, as shown by increased NRG-1 expression and phosphorylation of ErbB2 and ErbB4 receptors in the LV. As a novel and intriguing observation, we describe the appearance of a truncated form of ErbB2 in the myocardium. In breast tumours, expression of this form is known to be associated with constitutive receptor activity and with poor cancer outcome. Whether, in analogy, ErbB2 truncation in the myocardium can be interpreted as a further manifestation of activated ErbB2 signalling remains to be confirmed, but may have interesting clinical applications.
Detection and clustering of light charged particles via system‐identification techniques (2006)

Abstract The problem considered in this work is the classification of the particles produced by the collision of a heavy ion beam on a target. Each particle is captured by a detector and results in a signal (which is the impulse response of a dynamic linear system), which is measured by a digital acquisition system. The assumption made herein is that the shape of the impulse‐response contains complete information on the particle, and the classification can be done by pulse‐shape, analysis. In this work, a complete procedure for the particle identification is proposed. The main idea is to use the cascade of a state‐space identification algorithm and a parametric non‐linear map using the model parameters as input regressors. The algorithm has been tested on a large set of impulse‐responses and provides a fully automatic accurate classification of the isotopes. This work focuses on isotopic identification of the most energetic light charged particles (LCP). All the experiments are made with the large detector array CHIMERA (Charge Heavy Ions Mass and Energy Resolving Array). Copyright © 2006 John Wiley &amp; Sons, Ltd.
Histological techniques for the study of the biomaterial‐tissue interface of total joint replacements — a modification for the preservation of bone cement (1992)

Abstract The methods usually employed for the histological processing of orthopaedic specimens of cemented joint arthroplasties involve treatment with methacrylate monomer and organic solvents which dissolve the polymethylmethacrylate cement. This may distort the intimate relationship of the cell layers along the surface of the interface between the bone and the cemented implant. The authors report on a technique for the processing and embedding of cemented orthopaedic implants which permits preservation of the polymethylmethacrylate cement. The method utilizes a modification of Spurr's low viscosity epoxy resin and avoids the use of solvents such as acetone. Undecalcified sections of cemented joint replacements from animal studies and human specimens have been prepared using this method. It is possible to use these sections for detailed histomorphologic and histomorphometric analysis of bone tissue and of the soft tissue membrane adjacent to the polymethylmethacrylate cement.
Magnetic resonance imaging of pulse wave velocity in children aged 9 years to assess maternal influences on aortic stiffness in the offspring (2012)

Background Pulse wave velocity (PWV) is an indirect measure of vascular stiffness. Higher PWV is a recognised cardiovascular risk marker. Magnetic resonance imaging (MRI) is a non-invasive method of assessing PWV. Assessing maternal influences on offspring PWV is important as reduced fetal nutrient supply and impaired early development are linked with an increased risk of cardiovascular disease in adulthood. In multiparous women, changes in the uterine spiral arteries arising during previous pregnancies result in increased fetal nutrient supply. Rat studies have shown that changes in maternal fatty acid intake in pregnancy are associated with increased offspring arterial stiffness. Some studies of human adults suggest omega-3 fish oils reduce arterial stiffness. The objective of the study was to measure vascular stiffness using MRI, and examine maternal influences on vascular structure in children aged 9 years.
A new method to design fuzzy controller for unmanned autonomous forklift (2015)

This paper proposes a new method called Lyapunov-Conjugate Gradient Method (LCGM) to design fuzzy controller for unmanned autonomous forklift. The kinematic of a spin-turn mechanism is analyzed first, and then the design parameters are obtained. Based on the kinematic and the fuzzy Lyapunov synthesis proposed by Margaliot, we introduce the error weights coefficients to Lyapunov Function (LF) and derive the stable conditions. The fuzzy rule-bases are given. Next we design and optimize parameters of the Gaussian membership function by the Conjugate Gradient method. The smoother control surfaces are analyzed. Experiment results show that the type-1 controller designed by LCGM has a better performance in stability, smooth and robustness than commonly used conventional fuzzy-PID controller. Its steady lateral error and orientation error can be less than 10mm and 1 degree, respectively. A lot of unmanned forklifts that their controllers are designed by LCGM have been used in automatic plants.
ChemInform Abstract: AN IMPROVED SYNTHESIS OF SULFAMOYL CHLORIDES (1977)

Abstract Isocyanate (I) reagieren mit Schwefelsäure/Schwefeltrioxid zu den Sulfamidsäuren (II), die mit Phosphorpentachlorid die Sulfamoylchloride (III) geben.
Monotone Piecewise Bicubic Interpolation (1985)

In a 1980 paper [SIAM J. Numer. Anal., 17 (1980), pp. 238–246] the authors developed a univariate piecewise cubic interpolation algorithm which produces a monotone interpolant to monotone data. This paper is an extension of those results to monotone $\mathcal{C}^1 $ piecewise bicubic interpolation to data on a rectangular mesh. Such an interpolant is determined by the first partial derivatives and first mixed partial (twist) at the mesh points. Necessary and sufficient conditions on these derivatives are derived such that the resulting bicubic polynomial is monotone on a single rectangular element. These conditions are then simplified to a set of sufficient conditions for monotonicity. The latter are translated to a system of linear inequalities, which form the basis for a monotone piecewise bicubic interpolation algorithm.
Oxidative Cyclization of 2′,3′-O-Isopropylidene-Adenosines into 5′-O,8-Cycloadenosines with Lead Tetraacetate: Remarkable Effect of N6-Substituents on the Oxidation (1992)

Abstract Oxidation of 2′,3′-O-isopropylideneadenosines (1) with lead tetraacetate (LTA) in dry benzene resulted in the formation of the corresponding 5′-O,8-cyclo-2′,3′-O-isopropylideneadenosines (2), which has a new methodological implication for the chemical modification of adenosines. The occurrence of the oxidative cyclization was remarkably affected by the nature of N6-substituents: N6-benzoyl substitution prominently accelerated the oxidative cyclization in comparison with none and dimethyl substitutions. In the oxidation of N6,N6-dimethyladenosine (1d), an intriguing oxidative demethylation was observed.
Electronic Requirements for Macropolyhedral Boranes (2001)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic Requirements for Macropolyhedral BoranesEluvathingal D. Jemmis, Musiri M. Balakrishnarajan, and Pattath D. PancharatnaView Author Information School of Chemistry, University of Hyderabad, Hyderabad 500 046, India Cite this: Chem. Rev. 2002, 102, 1, 93–144Publication Date (Web):December 19, 2001Publication History Received21 May 2001Published online19 December 2001Published inissue 1 January 2002https://pubs.acs.org/doi/10.1021/cr990356xhttps://doi.org/10.1021/cr990356xresearch-articleACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views1773Altmetric-Citations199LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Boron,Cluster chemistry,Group 13 compounds,Hydrogen,Inorganic compounds Get e-Alerts
NGO Activism, Legitimacy, and Shareholder Value (2019)

Non-governmental organisations (NGOs) have significantly increased attempts at advocacy for corporate policy adoption and responsible business practices. Using a large NGO dataset that comprises approximately 7,000 NGO activist groups on more than 700 environmental, social and governance (ESG) issues all over the world, this study focuses on the motivations of NGO activism and estimates its impact on firm’s management practices and long-term financial performance. Using propensity score matching to select two homogeneous groups of firms that are or are not NGO targets, we find that firms with large size, poor share performance and poor environmental performance are more likely targeted by NGOs. Following one year and two years periods after NGO campaigns, the firm’s environmental performance score on average increases by 2.2 and 2.9, respectively. Based on a quasi-natural experiment that exploits the implementation of mandatory legislative acts on climate change issues in the UK, we find that NGO engaged firms are more responsive to mandatory legislative acts than NGO non- engaged firms, and such responsiveness is shown by improved environmental performance and firm value following the legislative shock.
Effect of high-dose intravenous vitamin C on inflammation in cancer patients (2012)

The high dose intravenous ascorbic acid therapy affects C-reactive protein levels and pro-inflammation cytokines in cancer patients. In our study, we found that modulation of inflammation by IVC correlated with decreases in tumor marker levels.In summary, our data support the hypothesis that high dose intravenous ascorbate treatments may reduce inflammation in cancer patients. Our results suggest that further investigations into the use of IVC to reduce inflammation in diseases where inflammation is relevant are warranted.
Factor of Determination of the Center of Gravity Point on Sitting of the Right and Left Axis in Patients with Hemiplegia. (1999)

The purpose of this study was to investigate the factor of determination of the center of gravity of the right and left axis in sitting of hemiplegic patients. Subjects were 30 hemiplegic patients. The subjects center of gravity point was measured during 1) natural sitting, 2) sitting on the non-paretic weight-bearing, and 3) sitting on the paretic weight-bearing under eyes open and eyes closed conditions for ten seconds. We calculated the middle point value for 2) and 3), and observed a correlation between the center of gravity point during natural sitting and the middle point. This result indicate that the center of gravity point is decided by relative position of the maximal voluntary weight-bearing of the non-paretic and paretic sides.
Pseudo-Two-Dimensional Structures (HXYH)3n2H6n (XY = GaN, SiC, GeC, SiSi, or GeGe; n = 1−3):  Density Functional Characterization of Structures and Energetics (2005)

Hybrid density functional calculations with effective core potential basis sets are performed for monomeric group 13/15 and group 14/14 analogues of cyclohexane, as well as for three different pseudo-two-dimensional structures that can be formed from expanding one and two concentric rings around the central one (trans-fused chairs, a rolling combination of trans- and cis-fused chairs, and cis-fused boats). Varying contributions from torsional strain, angle strain, electrostatics, and nontraditional H-H hydrogen bonding lead to different orderings and magnitudes of motif energies in the various systems: Homoatomic SiSi and GeGe systems prefer the trans-fused chair alternative and heteroatomic systems GaN, SiC, and GeC prefer the rolling chair. Decomposition of structure energies into characteristic fragment contributions indicates that pseudo-one-dimensional rods of poly(imidogallane) are thermodynamically more stable than any of the pseudo-two-dimensional structures.
Dynamics of intravital concentration of amino acid metabolites in human brain in post-traumatic period (2019)

Intracellular concentrations of N acetyaspartate (NAA), aspartate (Asp) and glutamate (Glu) were determined for the first time in human brain in vivo, and the effect of severe traumatic brain injury on NAA synthesis in acute and late post-traumatic period was investigated. In MRI‑negative frontal lobes one day after injury Asp and Glu levels were found to decrease by 45 and 35%, respectively, while NAA level decreased by only 16%. A negative correlation between NAA concentration and the ratio of Asp/Glu concentrations was found. In the long-term period, Glu level returned to normal, Asp level remained below normal by 60%, NAA level was reduced by 65% relative to normal, and Asp/Glu ratio significantly decreased. The obtained results revealed leading role of the neuronal aspartate-malate shuttle in violation of NAA synthesis.
A Logic Verifier Based on Boolean Comparison (1986)

This paper proposes a logic VERIFIER, which verifies the correctness of the gate-level design by comparing it with the behavioral description. An improved Boolean comparison technique, which assures the absence of errors without designer's assist, is proposed. The partitioning and the minimization techniques are effective to reduce the storage required, and indispensable to verify practical sized circuits. If the design is judged incorrect, the system analyzes the result and show the area containing errors. Experimental results have proved that the VERIFIER can detect design errors completely, and indicate them to the designers in comprehensible form.
Preparation and Reactivities of trans-[(E-PhCH=CHCH2CO)MBr(PPh3)2] (M = Pd, Pt) as Key Intermediates for Cyclocarbonylation of Cinnarayl Compounds (1988)

Abstract Reaction of Pd(CO)(PPh3)3 with trans- or cis-cinnamyl bromide under 20 atom of CO at room temperature gave trans-[(E-PhCH=CHCH2CO)PdBr(PPh3)2], (1), whereas similar reaction under 1 atom of CO afforded (η3-1-Ph-allyl)PdBr(PPh3) which was not converted into 1 under 20 atom of CO at room temperature. Very facile migration of the carbon–carbon double bond in 1 was observed in solution at ambient temperature. Treatment of 1 or its platinum analogue (1′) with Ac2O and Et3N under 60 atm of CO at 16O°C gave 1-naphthyl acetate in moderate yield.
Novel rare-earth-free tunable-color-emitting BCNO phosphors (2011)

We present a facile synthesis of novel, rare-earth (RE)-ion-free boron carbon oxynitride (BCNO) phosphors. The preparation method, chemical composition, luminescent properties and emission mechanisms, as well as current trends in BCNO phosphors are reviewed. The novel BCNO phosphors were synthesized from inexpensive and environmentally friendly raw materials by a straightforward route using liquid precursors at low temperatures under atmospheric pressure. The newly developed BCNO phosphors demonstrated tunable color emission, high quantum efficiency, and long-duration afterglow. The color emission of these phosphors can be tuned across almost the entire visible light spectrum by varying the molar ratios of the raw materials.
Tethered Ureteric Stents—a Clinical Assessment (1988)

The acceptability and complications of tethered double-J stents were assessed in 17 patients. The study showed tethered ureteric stents to be safe, well tolerated and easy to remove. The technique avoids unnecessary ureteral instrumentation and general anaesthesia and has benefits for both patients and hospital resources.
Photolysis (2016)

This glossary of terms covers phenomena considered under the very wide terms photocatalysis and radiation catalysis. A clear distinction is made between phenomena related to either photochemistry and photocatalysis or radiation chemistry and radiation catalysis. The term “radiation” is used here as embracing electromagnetic radiation of all wavelengths, but in general excluding fast-moving particles. Consistent definitions are given of terms in the areas mentioned above, as well as definitions of the most important parameters used for the quantitative description of the phenomena. Terms related to the up-scaling of photocatalytic processes for industrial applications have been included. This Glossary should be used together with the Glossary of terms used in photochemistry, 3rd edition, IUPAC Recommendations 2006: (doi:10.1351/pac200779030293) as well as with the IUPAC Compendium of Chemical Terminology, 2nd ed. (the “Gold Book” 2006–; doi:10.1351/goldbook), because many terms used in photocatalysis are defined in these documents.
Pathogenesis of Hyperthyroidism (2016)

Hyperthyroidism is a form of thyrotoxicosis in which there is excess thyroid hormone synthesis and secretion. Multiple etiologies can lead to a common clinical state of "thyrotoxicosis," which is a consequence of the high thyroid hormone levels and their action on different tissues of the body. The most common cause of thyrotoxicosis is Graves' disease, an autoimmune disorder in which stimulating thyrotropin receptor antibodies bind to thyroid stimulating hormone (TSH) receptors on thyroid cells and cause overproduction of thyroid hormones. Other etiologies include: forms of thyroiditis in which inflammation causes release of preformed hormone, following thyroid gland insult that is autoimmune, infectious, mechanical or medication induced; secretion of human chorionic gonadotropin in the setting of transient gestational thyrotoxicosis and trophoblastic tumors; pituitary thyrotropin release, and exposure to extra-thyroidal sources of thyroid hormone that may be endogenous or exogenous. © 2017 American Physiological Society. Compr Physiol 7:67-79, 2017.
Prognostický význam poklesu srdeční frekvence po zátěži u pacientů s chronickým srdečním selháním (2007)

Cilem teto prace bylo zhodnotit prognostický význam poklesu srdecni frekvence (PSF) po zatěži u pacientů s chronickým srdecnim selhanim (CHSS) a porovnat jej s jinými indikatory mortality. Metody: Byla provedena analýza dat 712 pacientů s CHSS, kteři podstoupili echokardiograficke a zatěžove vysetřeni. Výsledky: Pacienti byli rozděleni do 3 skupin podle PSF: skupina 1 (PSF ≤ 4 tepů/min), skupina 2 (5 ≤ PSF ≤ 9 tepů/min) a skupina 3 (PSF ≥ 10 tepů/min). Skupina 1 měla nejvyssi mortalitu v kratkodobem i dlouhodobem horizontu. PSF predikuje mortalitu nezavisle na věku, pohlavi, funkcni skupině, ejekcni frakci a BMI. Zavěr: PSF po zatěži může být využivan jako doplňkový prognostický ukazatel.
Synthesis of a hollow-beam pierce gun (1987)

An explicit procedure is developed for the design of a Pierce-type electron gun to deliver a hollow beam of specified voltage, current, inside and outside radii at the exit plane, and cathode current density. It is shown that the solution involves Euclid's Golden Ratio in an unexpected but valuable simplification. A comparison is made between a design obtained by this method and an analysis of that design using a well-established ray-tracing program. Agreement is satisfactory for engineering purposes.
Depressão no bebé (2012)

Os autores apresentam uma revisão critica do conceito de depressão na primeira infância com referência a sintomatologia, etiopatogenia e prognóstico. O estudo baseia-se na análise de 20 casos com o diagnóstico de depressão, que tiveram seguimento terapêutico na UPI nos anos de 1994 e 1995. Em todos os casos foram estudados os seguintes parâmetros: Motivo da consulta, Idade da criança, Início do sintoma, Perturbação do meio/parentalidade, Origem do pedido da consulta. Identificaram-se dois subgrupos que diferiam entre si pelo carácter agudo ou crónico da perturbação do meio, pelo tipo de associação de sintomas e pela idade da criança na altura do pedido de consulta. A diferente evolução terapêutica nestes dois subgrupos é ilustrada com a apresentação de dois casos clínicos.
Common sense based joint training of human activity recognizers (2007)

Given sensors to detect object use, commonsense priors of object usage in activities can reduce the need for labeled data in learning activity models. It is often useful, however, to understand how an object is being used, i.e., the action performed on it. We show how to add personal sensor data (e.g., accelerometers) to obtain this detail, with little labeling and feature selection overhead. By synchronizing the personal sensor data with object-use data, it is possible to use easily specified commonsense models to minimize labeling overhead.
Towards an evaluation framework for SOA security testing tools (2010)

Service-Oriented Architecture (SOA) is a paradigm that organizes and uses distributed capabilities to bring together a technical solution to a business problem. Despite the large and increasing dependency on SOA by the enterprise, testing SOA systems is still a nascent and immature field. In particular, testing SOA applications from a security perspective is an essential yet underserved activity. This paper presents preliminary work towards an evaluation framework for SOA security testing tools, in order to address the question "Which testing tool(s) provide(s) the best value in testing SOA security with respect to our needs and context?".