gebhart/patrepeval huggingface dataset:
Supplementary Table S2 from Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes (2023)

&lt;p&gt;Supplementary Table S2. Centroids of the 821 gene signature for the three super-groups&lt;/p&gt;
Hydranencephaly with Abnormal Genitalia (See Also ARX-Associated XLID)ARX-Associated XLID (2011)

Abstract This chapter provides pictures and clinical details of HYDRANENCEPHALY WITH ABNORMAL GENITALIA
유로화의 발전과 영국의 EMU 가입전망 (2005)

EU는 2010년까지 세계경제의 중심이 된다는 ‘리스본전략’을 구상하였으며 그 중심 에는 유로화가 있다. 유로화는 도입초기의 태생적 한계와 정치․경제적 문제를 극복하고 미국달러가 독점해온 국제금융시장에서 대안적 결제통화로서의 위상을 높이고 있다.
하지만 유로화의 강세는 유로지역의 경기회 복에 걸림돌로 작용할 수 있으며 특히, 수출...
A novel reconfigurable maze antenna for multi-service wireless universal receivers (2006)

A novel design of multi-band multi-service reconfigurable antenna has been developed, and is comprised of multi-segment printed loop structure. The developed antenna looks like a maze and can be easily configured by altering its multi-segment interconnectivity using multitude of switches. Modeled and measured results including the effects of the switching elements will be presented here in details.
Identifying PhosphoCTD-Associating Proteins (2004)

The C-terminal repeat domain (CTD) of the largest subunit of RNA polymerase II is hyperphosphorylated during transcription elongation. The phosphoCTD is known to bind to a subset of RNA processing factors and to several other nuclear proteins, thereby positioning them to efficiently carry out their elongation-linked functions. The authors propose that additional phosphoCTD-associating proteins (PCAPs) exist and describe a systematic biochemical approach for identifying such proteins. A binding probe is generated by using yeast CTD kinase I to exhaustively phosphorylate a CTD fusion protein. This phosphoCTD is used to probe fractionated yeast or mammalian extracts in a Far Western protein interaction assay. Putative PCAPs are further purified and identified by mass spectrometry.
Ensemble learning for brain computer-interface using uncooperative democratic echo state communities (2010)

This paper deals with the issue of features construction and selection for signals acquired during non-invasive Brain-Computer Interface (BCI) experiments. The so-called Echo State Network (ESN) architecture, a reservoir computing approach proposed by H. Jaeger in 2001, is first adapted to the specific issue of EEG signals classification. In order to predict the performed task, a commonly used ESN architecture is combined with regularized logistic regression trained following aggressive subsampling principles. The resulting method is shown to significantly outperform classification rates obtained using raw EEG signals. Basic single ESNs are then integrated to take advantage of ensemble learning techniques and aggressive subsampling principles. The resulting new architecture, called Uncooperative Democratic Echo State Community (UDESC), constitutes one of the first attempt to provide an efficient subject-independent features construction algorithm. Based on the generative power of individual ESNs as well as the discriminative abilities of ensemble learning combined with aggressive subsampling, it is shown to advantageously integrate the knowledge acquired by each single ESN. The results shown along this paper make an extensive use of a real training dataset made available to the BCI community during BCI Competition 2008. This dataset consists of four subjects involved in a two-class motor-imagery BCI experiments.
Stacked Microstrip Antenna with High Gain for Wireless Camera System (1991)

マイクロストリップアンテナは, 小型軽量であり, 機動性, 迅速性が要求されるワイヤレスカメラ用の送信アンテナとして有用性がある.マイクロストリップアンテナにおいて, 素子単体の利得は普通6～7 [dBi] 程度であるが, ワイヤレスカメラ用アンテナとしては10～12 [dBi] 程度が適当である.その利得は, 複数の素子を平面配列で構成して得られるが, 放射方向配列で構成しても実現できる.また, 無給電素子を放射素子上に近接しておくことで, インピーダンスが広帯域になる.本稿では, 放射素子上に無給電素子を配列した構成により, 高利得でかつインピーダンスが広帯域であるマイクロストリップアンテナを提案し, その特性について実験的に調べ, さらに, ワイヤレスカメラ用に試作し, 実用性を確かめている.
Turbulent Inflow Boundary Conditions for LES (2003)

Methods of generating turbulent in ow boundary conditions for LES and DNS are surveyed and ranked according to their e ectiveness. Methods included in the survey are random number pseudo turbulence, rescaling of isotropic turbulence data in space and/or time, Taylor's hypothesis applied to a frozen three-dimensional turbulent velocity eld, and the direct transfer of turbulent velocity data from an auxiliary simulation. The simpler approaches are shown to be acceptable for ows with strong inviscid instabilities such as distorted isotropic turbulence or turbulent wakes. These same approaches are found to fail in wall-bounded ows where weak viscous instabilities prevail. Wall-bounded ows appear to require the more sophisticated methods, which are largely based on the direct transfer of accuratelysimulated turbulent data. E cient means of generating such data are also surveyed. Very simple time-dependent, simulation-based in ow generation procedures such as a parallelow boundary layer are shown to yield a quantum leap in accuracy over the simpler methods, including those that apply Taylor's hypothesis to a accurately-simulated frozen velocity eld. While the parallelow boundary layer method is adequate in many cases, greater accuracy can be achieved if necessary by accounting for spatial growth e ects via Spalart's original method, or by more recent variants. These rather sophisticated methods are still cost e ective and can also account for the e ects of pressure gradients.
Pathobiology: when the tumor is the target. (2009)

Abstract Abstract #ES-5 Breast cancer evaluation and treatment has benefited markedly from expanding understanding of the anatomic and molecular mechanisms that control cell growth and metastasis. Traditional staging has been augmented by genomic-based assays, targetable differences among tumors have emerged, and the future holds promise that we will be able to individualize and optimize treatment based upon identifiable tumor and host characteristics. This education session will:&amp;#x2028; - Review molecular pathways relevant to breast cancer development and growth&amp;#x2028; - Discuss how genomics has expanded our understanding of breast cancer biology and behavior&amp;#x2028; - Examine how modern molecular biology is applied clinically Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr ES-5.
Low Loss Sol-Gel TiO2 Thin Films for Waveguiding Applications (2013)

TiO2 thin films were synthesized by sol-gel process: titanium tetraisopropoxide (TTIP) was dissolved in isopropanol, and then hydrolyzed by adding a water/isopropanol mixture with a controlled hydrolysis ratio. The as prepared sol was deposited by “dip-coating” on a glass substrate with a controlled withdrawal speed. The obtained films were annealed at 350 and 500 °C (2 h). The morphological properties of the prepared films were analyzed by Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM). The optical waveguiding properties of TiO2 films were investigated for both annealing temperature using m-lines spectroscopy. The refractive indices and the film thickness were determined from the measured effective indices. The results show that the synthesized planar waveguides are multimodes and demonstrate low propagation losses of 0.5 and 0.8 dB/cm for annealing temperature 350 and 500 °C, respectively.
Fluorescent Ca 2+ indicators directly inhibit the Na,K-ATPase and disrupt cellular functions (2018)

Fluorescent Ca<sup>2+</sup> indicators have been essential for the analysis of Ca<sup>2+</sup> signaling events in various cell types. We showed that chemical Ca<sup>2+</sup> indicators, but not a genetically encoded Ca<sup>2+</sup> indicator, potently suppressed the activity of Na<sup>+</sup>- and K<sup>+</sup>-dependent adenosine triphosphatase (Na,K-ATPase), independently of their Ca<sup>2+</sup> chelating activity. Loading of commonly used Ca<sup>2+</sup> indicators, including Fluo-4 acetoxymethyl (AM), Rhod-2 AM, and Fura-2 AM, and of the Ca<sup>2+</sup> chelator BAPTA AM into cultured mouse or human neurons, astrocytes, cardiomyocytes, or kidney proximal tubule epithelial cells suppressed Na,K-ATPase activity by 30 to 80%. Ca<sup>2+</sup> indicators also suppressed the agonist-induced activation of the Na,K-ATPase, altered metabolic status, and caused a dose-dependent loss of cell viability. Loading of Ca<sup>2+</sup> indicators into mice, which is carried out for two-photon imaging, markedly altered brain extracellular concentrations of K<sup>+</sup> and ATP. These results suggest that a critical review of data obtained with chemical Ca<sup>2+</sup> indicators may be necessary.
Complete Genome Sequence of Paenibacillus polymyxa CF05, a Strain of Plant Growth-Promoting Rhizobacterium with Elicitation of Induced Systemic Resistance (2015)

Paenibacillus polymyxa CF05 is a Gram-positive rod-shaped bacterium isolated from the interior of an ancient tree, Cryptomeria fortunei, in China. This bacterium displays potent biocontrol effects against certain soil-borne diseases and the elicitation of induced systemic resistance in tomatoes. Here, we report the complete genome sequence of P. polymyxa CF05.
Topology‐Dependent Cellular Interactions (2008)

This chapter contains sections titled: Cell Structure–Cell Function Dependence on Titanium Surfaces Cell Behavior on Micro- and Nanostructured Surfaces Resistivity of Cells Under Shear Load References
Effect of Mott-Hubbard correlations on the electronic structure and structural stability of uranium dioxide (1997)

Abstract The influence of Mott-Hubbard electron-electron correlations on the electronic structure and structural stability of uranium dioxide (UO2) has been analysed using the local spin-density approximation (LSDA) + U approach. We have found that the inclusion of a term describing the Hubbard on-site repulsion between 5f electrons results in a dramatic improvement in the description of the equilibrium electronic and magnetic structure of UO2 for which conventional LSDA calculations incorrectly predict a non-magnetic metallic ground state. We have found that the presence of electron-electron correlations in the 5f band modifies the character of chemical bonding in the material, leading to a Heitler-London type of hybridization between the 5f orbitals and giving rise to a larger value of the equilibrium lattice constant in better agreement with experimental observations.
Photophysical and Photochemical Processes of Excited Singlet and Triplet [3n]Cyclophanes (n = 2–6) Studied by Emission Measurements and Steady-State and Laser Flash Photolyses (2015)

Photophysical and photochemical features of [3n]cyclophanes (3nCPs) (n = 2-6) in solution were investigated by emission and transient absorption measurements. The studied 3nCPs show excimer fluorescence without locally excited fluorescence whereas some of them emit excimer phosphorescence in rigid glass at 77 K. The probability of excimeric phosphorescence from transannular π-electron systems was shown to strictly depend on the symmetric molecular structures. A feature of intersystem crossing from an excimeric fluorescence state to the excimeric triplet state was observed. Transient absorption spectra obtained upon laser flash photolysis of 3nCP revealed formation of the triplet excimer states. Triplet sensitization of 33CP using xanthone as the sensitizer demonstrated formation of triplet 33CP via triplet energy transfer whereas from the xanthone ketyl radical formation, it was inferred that triplet xanthone undergoes H atom abstraction from 32CP, providing a benzylic 32CP radical as the counter species. Based on kinetic and spectroscopic data obtained upon laser flash photolysis, differences in photochemical reactions of triplet xanthone between 32CP and 33CP were discussed.
Activity of Toscana and Rift Valley fever virus transcription complexes on heterologous templates (2001)

A transcription system for Toscana virus (TOSV) (a member of the family BUNYAVIRIDAE:, genus PHLEBOVIRUS:) was constructed. For in vivo expression, the TOSV transcription system uses the viral N and L proteins and an S-like RNA genome containing the chloramphenicol acetyltransferase reporter gene in the antisense orientation flanked by the viral genomic 5'- and 3'-terminal S sequences. It was found that the N and L proteins represent the minimal protein requirement for an active transcription complex. To investigate the possibility of reassortment between TOSV and Rift Valley fever virus (RVFV), the activity of their polymerase complexes was tested on their heterologous S-like RNA genomes and this showed that both virus complexes were active. Moreover, hybrid transcriptase complexes with protein components originating from the two viruses were tested on both virus templates and only the combination RVFV L + TOSV N on RVFV S-like RNA was found to be active in this assay. These results suggest that virus reassortants might be generated whenever the two viruses infect the same host.
Potentially-implantable, ferrocene-mediated glucose sensor (1986)

We describe the construction and in vitro testing of a new potentially-implantable amperometric glucose sensor which is based on mediated electron transfer between immobilized glucose oxidase and a graphite base electrode. Under potentiostatic control, entrapped 1,1'-dimethylferrocene acts as an alternative electron acceptor to oxygen and provides a sensing strategy which is relatively unaffected by possible fluctuations in in vivo oxygen tension. Simple 1 mm wide electrodes with a polyurethane membrane gave linear current responses to at least 20 mmol/l glucose with a mean response time of 68 s. An acceptable proportion (17%) of electrodes had low or zero drift over 17 h at 37 degrees C. With plasma samples from diabetic and non-diabetic subjects, glucose concentrations measured by the sensor were significantly correlated with values obtained by a reference laboratory glucose analyser but were proportionally lower. Extension of this study to in vivo testing and further miniaturization of electrodes is justified.
Matrix stiffness regulates Notch signaling activity in endothelial cells (2022)

Abstract The Notch signaling pathway plays a critical role in many developmental and disease related processes. It is widely accepted that Notch has a mechano-transduction module that regulates cleavage of the receptor. However, the role of biomechanical properties of the cellular environment on this module and on Notch signaling in general is still poorly understood. During angiogenesis, differentiation into tip and stalk cells is regulated by Notch. The endothelial cells in this process respond to biochemical and mechanical cues triggered by local stiffening of the ECM. Here, we investigated the influence of substrate stiffness on the Notch signaling pathway in endothelial cells. Using stiffness tuned PDMS substrates we show that Notch signaling pathway activity inversely correlates with the physiologically relevant substrate stiffness, with increased Notch activity on softer substrates. We show that trans-endocytosis of the Notch extracellular domain, but not the overall endocytosis, is regulated by substrate stiffness. Furthermore, we could show that integrin cell-matrix connections are both stiffness-dependent and influenced by Notch. Cadherin mediated cell-cell adhesion and Notch, however, influence each other in that basal Notch signaling is cell-cell contact dependent, but inhibition of the Notch signaling pathway also results in a reduction of VE-cadherin levels. We conclude that mechano-transduction of Notch activation depends on substrate stiffness highlighting the role of substrate rigidity as a modulator of Notch signaling. This may have important implications in pathological situations, such as tumor growth, associated with stiffening of the extracellular matrix.
Structural Requirements for Catalysis and Membrane Targeting of Mammalian Enzymes with Neutral Sphingomyelinase and Lysophospholipid Phospholipase C Activities (2000)

The sequence similarity with bacterial neutral sphingomyelinase resulted in the isolation of putative mammalian counterparts and, subsequently, identification of similar molecules in a number of other eukaryotic organisms. Based on sequence similarities and previous characterization of the mammalian enzymes, we have chemically modified specific residues and performed site-directed mutagenesis in order to identify critical catalytic residues and determinants for membrane localization. Modification of histidine residues and the substrate protection experiments demonstrated the presence of reactive histidine residues within the active site. Site directed mutagenesis suggested an essential role in catalysis for two histidine residues (His-136 and His-272), which are conserved in all sequences. Mutations of two additional histidines (His-138 and His-151), conserved only in eukaryotes, resulted in reduced neutral sphingomyelinase activity. In addition to sphingomyelin, the enzyme also hydrolyzed lysophosphatidylcholine. Exposure to an oxidizing environment or modification of cysteine residues using several specific compounds also inactivated the enzyme. Site-directed mutagenesis of eight cysteine residues and gel-shift analysis demonstrated that these residues did not participate in the catalytic reaction and suggested the involvement of cysteines in the formation/breakage of disulfide bonds, which could underlie the reversible inactivation by the oxidizing compounds. Cellular localization studies of a series of deletion mutants, expressed as green fluorescent protein fusion proteins, demonstrated that the transmembrane region contains determinants for the endoplasmic reticulum localization.
Guided Task Planning Under Complex Constraints (2022)

Creating a plan, i.e., composing a sequence of items to achieve a task is inherently complex if done manually. This requires not only finding a sequence of relevant items but also understanding user requirements and incorporating them as constraints. For instance, in course planning, items are core and elective courses, and degree requirements capture their complex dependencies as constraints. In trip planning, items are points of interest (POIs) and constraints represent time and monetary budget, two user-specified requirements. Most importantly, a plan must comply with the ideal interleaving of items to achieve a goal such as enhancing students' skills towards the broader learning goal of an education program, or in the travel scenario, improving the overall user experience. We study the Task Planning Problem (TPP) with the goal of generating a sequence of items that optimizes multiple objectives while satisfying complex constraints. TPP is modeled as a Constrained Markov Decision Process, and we adapt weighted Reinforcement Learning to learn a policy that satisfies complex dependencies between items, user requirements, and satisfaction. We present a computational framework RL-Planner for TPP. RL-Planner requires minimal input from domain experts (academic advisors for courses, or travel agents for trips), yet produces personalized plans satisfying all constraints. We run extensive experiments on datasets from university programs and from travel agencies. We compare our solutions with plans drafted by human experts and with fully automated approaches. Our experiments corroborate that existing automated solutions are not suitable to solve TPP and that our plans are highly comparable to expensive handcrafted ones.
Microwave‐Assisted Solvent‐Free Synthesis of Ipsapirone (2019)

The currently applied synthetic methods of serotonin receptor ligands belonging to the group of long‐chain arylpiperazines, including ipsapirone, require the use of toxic solvents and comprise numerous synthetic steps. Moreover, the reaction yield does not exceed 60% in the majority of cases. These factors lead to an increased energy consumption and negatively impact the environment. This paper describes a more environmentally friendly method of ipsapirone synthesis that we decided to use. Ipsapirone was obtained in two different methods. The first method involved N ‐alkylation of bromobutyl saccharin with 1‐(2‐pyrimidyl)piperazine dihydrochloride, while the second was a one‐pot method. Neither of these requires the use of toxic and expensive solvents. A shortened synthesis time, not exceeding 10 min due to the use of microwave radiation, is also another advantage of these methods. The yield of the final product, ipsapirone, was 85% and 67% in the first and the second method, respectively. We also attempted to obtain ipsapirone using saccharin and arylpiperazine salt (method III) as starting materials, but to no avail in the tested conditions. As described herein, the green chemistry method for ipsapirone synthesis is rapid, cost‐effective, and environment friendly.
The relative lethality of intestinal bacteria for gnotobiotic rats with experimental intestinal strangulation. (1992)

In eight experiments utilizing 28 animals each, germfree rats with and without ischemically or hemorrhagically strangulated closed loop intestinal segments were contaminated with either one of four common intestinal anaerobic bacteria, or a combination of two or three bacteria previously found to be innocuous in pure culture. The results showed that: a) in pure culture, Bacteroides fragilis, Bacteroides melaninogenicus, and Peptostreptococcus anaerobius were innocuous; b) Fusobacterium necrophorum alone was a very lethal organism that produced intense, confluent, intraperitoneal, fibrous adhesions after four to six days; and c) mixed inoculum of Klebsiella pneumoniae, Bacteroides fragilis, and/or Streptococcus faecalis was found to be lethal for gnotobiotic rats with intestinal strangulation. It is concluded that Fusobacterium necrophorum is so patent that it should be specifically treated with antibiotics when suspected or known to be present in clinical specimens. This gnotobiotic animal model will be useful to delineate the lethality of known combinations of intestinal bacteria.
Automatic segmentation of intravascular optical coherence tomography images for facilitating quantitative diagnosis of atherosclerosis (2011)

Quantitative diagnosis of atherosclerosis can be facilitated by automatic segmentation of intravascular Optical Coherence Tomography (OCT) images. We report an automatic method of lumen and calcified plaque segmentation for commercial intravascular OCT systems. Lumen segmentation is based on a dynamic programming scheme. Calcified plaque is localized by edge detection and finely traced using an active contour model. The proposed methods yield promising results when applied to clinical images as validated by manual tracing. Lumen segmentation is useful for estimating the coronary artery stenosis and guiding stent implantation. Calcified plaque segmentation can be used to estimate the distribution of superficial calcification and inform strategies for coronary stenting.
ChemInform Abstract: Enantioselective Preparation of 2,4‐Disubstituted Azetidines. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Vector-based equalization method to mitigate core-to-core Q-difference for space-division multiplexing transmission (2017)

The vector-based quality equalization method is proposed to mitigate the core-to-core Q-difference for multicore fiber transmission. The multiple signals are combined and separated with transfer function in vector domain. It is confirmed that it is effective at larger SNR difference case compared to the bit-based equalization method numerically.