gebhart/patrepeval huggingface dataset:
Structural Modifications of a Hard Deep Clayey Rock due to Hygro-Mechanical Solicitations (2007)

Wetting/drying tests including cycling effects were performed on an argillaceous deep rock coming from a Callovo–Oxfordian deposit in eastern France. Bulk volume and water content were measured in order to estimate the importance of physical changes. Then, mercury intrusion porosimetry (MIP) was performed on dry and moist samples in order to quantify the influence of hydraulic history on fracture. Results showed that shrinkage and swelling caused microcracks, which led to volume variations thus altering the structures of the rock. MIP tests performed on moist samples equilibrated with different hygrometric saline solutions allow unsaturated pores and classic water retention curves to be described so as to explain changes in the microstructure.
Silicon waveguides and filters in hyperuniform disordered photonic solids for the near-infrared (2014)

We report preliminary results for silicon waveguides and devices in hyperuniform disordered photonic solids. Temperature sensitivity of resonant defects is more than 500 times lower than that of the standard silicon microring resonators.
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells (1997)

1. Eight types and subtypes of the mouse prostanoid receptor, the prostaglandin D (DP) receptor, the prostaglandin F (FP) receptor, the prostaglandin I (IP) receptor, the thromboxane A (TP) receptor and the EP1, EP2, EP3 and EP4 subtypes of the prostaglandin E receptor, were stably expressed in Chinese hamster ovary cells. Their ligand binding characteristics were examined with thirty two prostanoids and their analogues by determining the Ki values from the displacement curves of radioligand binding to the respective receptors. 2. The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP. 3. The FP receptor bound PGF2 alpha and fluprostenol with Ki values of 3-4 nM. In addition, PGD2, 17-phenyl-PGE2, STA2, I-BOP, PGE2 and M&B-28767 bound to this receptor with Ki values less than 100 nM. 4. The EP1 receptor bound 17-phenyl-PGE2, sulprostone and iloprost in addition to PGE2 and PGE1, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative EP1 antagonists, AH6809 and SC-19220, did not show any significant binding to this receptor. M&B-28767, a putative EP3 agonist, and misoprostol, a putative EP2/EP3 agonist, also bound to this receptor with Ki values of 120 nM. 5. The EP2 and EP4 receptors showed similar binding profiles. They bound 16,16-dimethyl PGE2 and 11-deoxy-PGE1 in addition to PGE2 and PGE1. The two receptors were discriminated by butaprost, AH-13205 and AH-6809 that bound to the EP2 receptor but not to the EP4 receptor, and by 1-OH-PGE1 that bound to the EP4 but not to the EP2 receptor. 6. The EP3 receptor showed the broadest binding profile, and bound sulprostone, M&B-28767, GR63799X, 11-deoxy-PGE1, 16,16-dimethyl-PGE2 and 17-phenyl-PGE2, in addition to PGE2 and PGE1, with Ki values of 0.6-3.7 nM. In addition, three IP ligands, iloprost, carbacyclin and isocarbacyclin, and one TP ligand, STA2, bound to this receptor with Ki values comparable to the Ki values of these compounds for the IP and TP receptors, respectively. 7. 8-Epi-PGF2 alpha showed only weak binding to the IP, TP, FP, EP2 and EP3 receptor at 10 microM concentration.
Mode and logic-based switching for the formation flying control of multiple spacecraft (2001)

Mode and logic-based switching for formation flying control is motivated and addressed in the context of separated spacecraft optical interferometry. It is shown that logic-based switching is an attractive approach for satisfying multiple performance criteria during the different phases of a representative formation flying mission. Simulation results are included to demonstrate the need for introducing logic-based switching, its mechanism, and its performance.
Analysis of the Kinesin-13 gene family in plants (2012)

Although the depolymerizing effects of animal kinesin-13 proteins have been well characterized, little is known of the two Arabidopsis kinesin-13 proteins. This project aimed to investigate in more detail the functions of AtKinesin-13A/B and their effect on microtubule dynamics. The first aim was to analyse the function of both proteins in vitro using biochemical studies. Proteins were expressed in both bacterial and insect cells before undergoing co-sedimentation and turbidimetric assays to assess their activity and microtubule-interacting properties. The second aim of this project was to investigate the in vivo effects of these proteins on microtubule dynamics throughout the cell cycle. Tobacco BY2 cell lines were transformed with AtKinesin-13A and 13B, as well as human HsKinesin-13 for comparison under the expression of an estradiol-inducible promoter. This inducible system allowed transient expression of recombinant protein to analyse the effect of expression on cell growth, nuclear morphology and microtubule dynamics by immunofluorescence microscopy.&#13;\n&#13;\nThese experiments show that AtKin13B appears to function during metaphase in aiding activation of the metaphase spindle checkpoint and subsequent progression through the cell cycle. Biochemical studies into its relationship with microtubules, combined with in vivo induction data, suggest that AtKin13B may have a subtle destabilizing effect on microtubules. Biochemical studies with AtKin13A showed that it binds specifically to microtubules, and it localized to chromosome arms in a similar pattern to AtKin13B, but may have different effects in plants. Human Kinesin-13 localized exclusively to spindle microtubules throughout the cell cycle showing that the activity of kinesin-13 proteins is species-specific and animal kinesins have little effect in plant systems. &#13;\n
Myocardial Infarction and Mortality in the Coronary Artery Surgery Study (CASS) Randomized Trial (1984)

The long-term benefit of coronary bypass surgery in terms of longevity and prevention of major ischemic events in patients who have mild angina is not well defined. The randomized Coronary Artery Surgery Study (CASS) was designed to evaluate this issue; it consists of 780 patients who were considered operable and who had mild stable angina pectoris or who were free of angina after infarction. As a result of the randomization process there were no significant differences in base-line variables between patients randomly assigned to medical and to surgical therapy. The likelihood of death in the five-year period after randomization was only 8 per cent in the medical cohort, as compared with 5 per cent in the surgical cohort (not significant). The likelihood of nonfatal Q-wave myocardial infarction was 11 and 14 per cent, respectively (not significant). The five-year probability of remaining alive and free of infarction was 82 per cent in the patients assigned to medical therapy and 83 per cent in the patients assigned to surgery (not significant). There were no statistically significant differences in the survival rate or in the myocardial-infarction rate between subgroups of patients randomly assigned to medical and to surgical therapy when they were analyzed according to initial group assignment, number of diseased vessels, or ejection fraction. Therefore, as compared with medical therapy, coronary bypass surgery appears neither to prolong life nor to prevent myocardial infarction in patients who have mild angina or who are asymptomatic after infarction in the five-year period after coronary angiography.
Inhibition of human pancreatic alpha-amylase by montbretin A: a new drug for diabetes and obesity? (2008)

The gene encoding penicillin binding protein 4 and 5 of Haemophilus influenzae were cloned into the high-expression plasmid pET28 and overexpressed in Escherichia coli BL21 (DE3) star / pLysS respectively. Each proteins were purified more than 95 % and initial crystals were obtained by sitting-drop vapour-diffusion method at 293 K in a lot of conditions. After optimization of each conditions, the single crystals were grown at 293 K, 1 week for data collection. The HiPBP4 crystals belonged to space group P21 with unit-cell parameters a = 64.55 , b = 92.59 , c = 104.88 and = 107.75. and the HiPBP5 crystals belonged to space group P212121 with unit-cell parameters a = 41.13 , b = 53.01 , c = 201.79 . These crystals complete data set were collected at Photon factory.
Peripheral blood monoclonal plasma cells as a predictor of survival in patients with multiple myeloma [see comments] (1996)

The purpose of this study was to quantitate the number and labeling index of monoclonal plasma cells in the blood of patients with newly diagnosed multiple myeloma (MM) to learn if these values were independent prognostic factors for survival. Patients were candidates for this study if they had untreated myeloma requiring therapy, were evaluated at our institution between 1984 and 1993, and had a sample of blood analyzed with a sensitive immunofluorescence technique for monoclonal plasma cells and the blood B-cell labelling index (BLI). The % blood monoclonal plasma cells (%BPC) and the BLI were analyzed along with stage, marrow plasma cell LI, % marrow plasma cells, calcium, creatinine, albumin, beta-2-microglobulin, and C-reactive protein as univariate and multivariate factors for survival. Eighty percent of the 254 patients accrued to this study had monoclonal BPC detected. The median % BPC was 6% and 57% (144 of 254) of patients had a high number (> or = 4%). Patients with > or = 4% BPC had a median survival of 2.4 years vs 4.4 years for those with < 4% BPC (P < .001). The BLI was also prognostic (P = .008). In a multivariate analysis, the % BPC, age, albumin, stage, marrow plasma cell LI, and the BLI were independent factors for survival. The %BPC and the marrow plasma cell LI best separated the group into low, intermediate, and high risk myeloma with median survivals of 52, 35, and 26 months, respectively. Patients with high %BPC were less likely to have lytic bone disease from their MM (P = .002). The %BPC and the BLI are independent prognostic factors for survival and are useful in identifying patients as low, intermediate, and high risk. Clonal cells in the blood should be quantified in future clinical trials for myeloma.
Lithocholate metabolism in baboons fed chenodeoxycholate. (1982)

The administration of chenodeoxycholate to most species results in hepatic lesions presumed to be due to lithocholate formed from chenodeoxycholate. The relative failure of humans to develop similar lesions may be due to differences in lithocholate metabolism, primarily extensive sulfation and rapid elimination of lithocholates. To gain further insight into species differences in response to chenodeoxycholate, the metabolism of 14C-lithocholate was studied in four female baboons with functioning gallbladders. The distribution of metabolites in bile and the kinetics of of 14C-lithocholate in the taurine- and glycine-conjugated pools were studied in two animals receiving chenodeoxycholate and in two controls. Only 10% of the metabolites were sulfated, with an additional 10% occurring as more polar compounds; there was no difference between treated and control animals. Kinetic studies showed inputs and pool sizes that were two to three times greater in treated animals than in controls. Fractional turnover rates were much slower than in humans or cholecystectomized monkeys and pool sizes were much larger. The results of these studies, the first in animals with functioning gallbladders, support the hypothesis that sulfation plays an important role in protecting humans against lithocholate toxicity. There also may be differences in the extent to which chenodeoxycholate is converted to lithocholate and absorbed to enter the circulating pool.
Electromagnetic wave scattering from planar periodic metallic surfaces (1988)

The analysis of infinite periodic planar structures with apertures along some axis is of great importance due to the frequency-selective and polarization-selective properties exhibited by them. The properties of these surfaces are dependent on the shape of the aperture and the mutual coupling with nearby elements in the array. We extend our solution for the scattering of waves from a strip grating to be applicable in the 2-D case. The electric and magnetic field distributions in the plane of the scattering surface are expanded in a modified Fourier series (FS), and an infinite dimensional system of linear equations is derived by mapping the FS coefficients of the electric and magnetic fields onto components of a vector and representing each step of the Tsao-Mittra spectral iteration process as a matrix multiplication. This system of equations is equivalent to that obtained using the moment method and is solved using standard techniques. Unlike various solution procedures which are applicable only in the case of a specific-shaped aperture, our procedure is applicable and produces accurate results in the case of many different frequency-selective surfaces. Scattering from rectangular strip (wire) meshes, circular patches, and narrow slots is considered. Comparison of results with those obtained using other methods support the validity of the solution procedure.
A Review of the Effects of Prenatal Cocaine Exposure Among School-Aged Children (2010)

Consistent with findings among preschool-aged children, environmental variables play a key role in moderating and explaining the effects of PCE on school-aged children's functioning. After controlling for these effects, PCE-related impairments are reliably reported in sustained attention and behavioral self-regulation among school-aged children.
ChemInform Abstract: Comments on Quasicrystals and Their Potential Use as Catalysts (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Sound Insulation of Wooden Three-layered Material I. (2010)

本研究では，スギ角材およびスギ合板等で構成された3層構造壁材の音響透過損失をJIS A 1416，JIS A 1419-1により計測・評価し，在来工法での壁材と比較した。結果は以下のとおりである。（1）今回開発した3層構造壁は在来工法壁に比べ全周波数帯域で高い空気音遮断性能が見られた。（2）3層構造壁は2000 Hzから4000 Hz帯域にかけてコインシデンス効果が現れにくかった。（3）3層構造壁は二重壁で懸念されるコンセント穴よる空気音遮断性能の低減は殆ど認められず，中心板の空気音遮断効果が確認できた。（4）RCコンクリート壁，ALC壁の片面あるいは両面にGLボンドを用いた二重あるいは三重壁においては，200 Hzから400 Hz帯域に共鳴透過による著しい遮音欠損が発生するが，今回開発したすべての3層壁材は，共鳴透過による遮音欠損は小さかった。
Abstract PR002: Global proteomic profiling of endometrial carcinomas identify prognostic markers (2021)

Abstract While endometrial cancer (EC) has an overall good prognosis, some patients do poorly and there is room for refinement within current classification systems. Using the TCGA prognostic grouping of EC, our group developed the Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE), which reliably and reproducibly stratifies ECs into four prognostic groups: POLEmut, p53wt/NSMP, MMRd (mismatch repair deficient), and p53abn, with the best prognosis for POLEmut to worst prognosis for p53abn. In the current study, global proteomic analysis was performed using the clinical SP3-CTP workflow on archival tissues from 151 patients including 40 MMRd, 34 POLEmut, 34 p53abn and 43 p53wt/NSMP, with clinical follow up data. Included in the cohort were 11 replicate samples (different parts of the same tumor) to examine spatial heterogeneity in the proteomic profiles. Replicate samples were highly correlated to each other, with the exception of three POLEmut cases with very poor correlation in the proteome in different parts of the tumor. As POLEmut tumors have an exceedingly high mutation burden, it is not surprising that this translates to heterogeneity at the proteomic level. Disease specific survival was examined to determine prognostic significance within the whole cohort and within individual molecular subgroups. High TOMM34, PLTP or TSFM expression was correlated to poor disease specific survival in the whole cohort and independently prognostic when molecular subtype, grade and histotype are considered. High MGST, NCL or XPNPEP3 were associated with poor outcomes within the p53wt/NSMP group. POLD2 and ENAH were prognostic within the MMRd group. Within the p53abn group, ACADVL and BABAM1 were found to be prognostic, and GRB7 was found to be enriched in the p53abn group compared to other molecular subtypes. As the group with the worst prognosis, p53abn group could benefit from novel therapeutic avenues. ACADVL, BABAM1 and GRB7 all lie within pathways that are potentially targetable. Our proteomic analysis has identified prognostic markers that may be useful in further refining current molecular classification to help guide treatment decisions. Furthermore, new therapeutic interventions could be developed to target proteins and pathways identified by this proteomics screen. Citation Format: Dawn R. Cochrane, Gian Negri, Jutta Huvila, David A. Farnell, Emily Thompson, Winnie Yang, Genny Trigo-Gonzales, Amy Lum, Sandra Spencer, Ryan Riley, Samuel Leung, Christine Chow, Jamie Lim, Martin Koebel, Stefan Kommoss, Friedrich Kommoss, Lien Hoang, David G. Huntsman, Gregg Morin, Jessica N. McAlpine. Global proteomic profiling of endometrial carcinomas identify prognostic markers [abstract]. In: Proceedings of the AACR Virtual Special Conference: Endometrial Cancer: New Biology Driving Research and Treatment; 2020 Nov 9-10. Philadelphia (PA): AACR; Clin Cancer Res 2021;27(3_Suppl):Abstract nr PR002.
Local resistance measurement on polycrystalline silicon layer in low-temperature poly-Si thin film transistor using scanning spreading resistance microscopy (2006)

A local resistance of a low‐temperature polycrystalline silicon in a thin film transistor (TFT) for a liquid crystal display was measured using scanning spreading resistance microscopy for investigating an activation of dopant atoms. The observed TFTs had lightly doped drain (LDD) structures with lengths of 0.6 μm and 1.0 μm. The measured local resistance ranges by 4 – 6 orders of magnitude for measuring points. The resistance data were separated into two groups: the higher resistance data were inside the grains and at the center of the grain boundaries, while the lower resistance data were near‐by the grain boundaries. The lower resistance data were evaluated, since the TFT operation current usually flows through the lower resistance area. From the lower resistance data, the drastic resistance change from the channel to the drain regions, which is LDD, were observed in both samples. The LDD lengths of two samples are found to be approximately 0.6 and 1.0 μm, respectively.
Supercritical fluid extraction of lipids from deep‐fried food products (1997)

Abstract A supercritical fluid extraction (SFE) method is described for extracting lipids from fried‐food samples. Response surface analysis was used to study the effects of variables, including pressure, temperature, flow rate, and modifier (methanol) on lipid extraction by SFE. The analysis of variance for the response variables indicated that the models developed were satisfactory with coefficients of determination of 0.95 and 0.92 for chicken nuggets and potato fries, respectively. The models predicted that increasing the pressure increased the percentage lipid extracted for both chicken nuggets and potato fries. In addition, the pressure by temperature interactions were significant for chicken nuggets and potato fries. Slight differences in fatty acid composition were observed between SFE and the Goldfisch method. The SF extracts contained traces of C 12:0 , C 20:0 , and C 24:0 in chicken nuggets and C 14:1 , C 18:3 , C 22:0 , and C 23:0 in potato fries, respectively, which are not found in the Goldfisch extracts. The optimal conditions for extraction are: 53 MPa, 150°C, 4 mL/min, and 10% modifier for chicken nuggets and 53 MPa, 150°C, 3 mL/min, and 0% modifier for potato fries. To duplicate the results of exhaustive Goldfisch extraction with petroleum ether, SFE conditions of 44 MPa, 80°C, 3 mL/min, and 0% modifier were used to produce similar results for both chicken nuggets and potato fries.
Primary Central Nervous System Lymphoma (2014)

International Ophthalmology Clinics 55(1):p 111-121, Winter 2015. | DOI: 10.1097/IIO.0000000000000055
Influence of naturally grown nanoparticles at the buffer layer in the flux pinning in YBa2Cu3O7coated conductors (2006)

We have studied the influence of naturally grown SrTiO3 particles at the buffer layer surface on the in-field critical current density (Jc) dependence of coated conductors. The presence of the SrTiO3 particles induces the growth of extra-correlated pinning along the c-axis direction in the YBa2Cu3O7 films that thread samples as thick as 5 µm. These correlated pinning centres produce a bigger c-axis peak and effectively reduce the Jc magnetic field (H) decay characterized by a smaller exponent α of the power law decay. This method opens up a new approach for how to increase Jc under an applied magnetic field without the need for an extra process. This study brings new meaning to the so-called optimal deposition conditions, since it will depend on the field and temperature region of the application.
Guided tissue regeneration for implants placed into extraction sockets: a study in dogs (1992)

Twelve 10 mm implants were placed into immediate extraction sockets in dogs. Six implants were isolated with PTFE membranes and 6 sites served as controls. Standardized clinical measurements were taken at test and control sites. At 18 weeks the dogs were anesthetized and flaps were laid for the purpose of obtaining clinical measurements. The average gain of bone around augmented implants was 2.6 mm, while control sites had an average bone gain of 1.0 mm. Ridge width adjacent to augmented sites increased by 1.2 mm and control sites had an increased width of 0.6 mm. Histologic evaluation of test and control specimens showed greater bone formation around augmented implants. Implants augmented with PTFE membranes had clinically significant amounts of bone regeneration when compared with controls. J Periodontol 1991; 62:703–709.
Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L.) and Clues to Its Anti-COVID-19 Utility (2021)

The current COronaVIrus Disease 19 (COVID-19) pandemic caused by SARS-CoV-2 infection is enormously affecting the worldwide health and economy. In the wait for an effective global immunization, the development of a specific therapeutic protocol to treat COVID-19 patients is clearly necessary as a short-term solution of the problem. Drug repurposing and herbal medicine represent two of the most explored strategies for an anti-COVID-19 drug discovery. Clove (<i>Syzygium aromaticum</i> L.) is a well-known culinary spice that has been used for centuries in folk medicine in many disorders. Interestingly, traditional medicines have used clove since ancient times to treat respiratory ailments, whilst clove ingredients show antiviral and anti-inflammatory properties. Other interesting features are the clove antithrombotic, immunostimulatory, and antibacterial effects. Thus, in this review, we discuss the potential role of clove in the frame of anti-COVID-19 therapy, focusing on the antiviral, anti-inflammatory, and antithrombotic effects of clove and its molecular constituents described in the scientific literature.