gebhart/patrepeval huggingface dataset:
An analysis of image‐sticking effect by transmittance drift measurement in liquid crystal cells (1995)

Abstract The image sticking effect in a thin‐film transistor activated liquid crystal display (TFT‐LCD) was related to the transmittance drift caused by dc voltage applied to liquid crystal (LC) cells. Using the electrooptical property of LC, the transmittance drift was calculated based on the drift of the residual dc potential which causes the image sticking effect. The transmittance drift calculated using the experimental result of the residual potential shift agreed with the measured transmittance drift. It was concluded that this calculation method was effective in analyzing the image sticking effect of LC cells.
Torque Characterization of a Novel Pneumatic Soft-and-Rigid Hybrid Actuator (2017)

This paper presents development of a theoretical model for predicting the torque generated by a pneumatic soft-and-rigid hybrid actuator at a given actuation pressure and bending angle. The soft actuator with a novel architecture is comprised of half bellow-shaped flexible hollow structure (soft section) in-between block-shaped semi-rigid sections made of silicone rubber materials. This actuator provides forward and backward bending motion when air pressure and vacuum are applied into the soft section, respectively. A simplified steady-state model was developed based on the quasi-static assumption when the system dynamics is slow enough that all of the interacting forces comes to an equilibrium at any given bending angle during the motion. The elastomeric material was modeled using the Yeoh 3rd order model to capture its nonlinear behavior. The model was studied for the soft actuators with different geometrical features in two cases of the free end motion (without external force) and the constrained end motion (with external force). Experimental testing and finite element simulations were carried out corresponding to the case-studies to validate the model. Comparison of the results obtained by these two approaches show a good agreement with the theoretical model’s prediction.
Design of a Clinical Balance Tool for Falls Risk Assessment: Development and Usability Study (Preprint) (2022)

<sec> <title>BACKGROUND</title> Falls are a significant source of early morbidity and mortality in the aging population, yet the neurological, sensory, and motor changes that lead to increased falls risk often escape early identification and intervention. Measurement of postural control in the clinical setting could facilitate evidence-based falls risk assessment. </sec> <sec> <title>OBJECTIVE</title> The two main objectives were to develop a prototype quantitative postural control measurement tool (qPCM) for measurement to replace a weight scale and to understand barriers and facilitators to assessing falls risk that could be addressed by qPCM. </sec> <sec> <title>METHODS</title> An observational study in the practice setting was conducted with two rounds of semi-structured interviews over seven months to evaluate critical functionality and workflow requirements to inform the design of the qPCM. Physicians (8), Medical Assistants or Physician Extenders (8), and Nurse Practitioners (2) were recruited from physician- and nurse-practitioner-run outpatient clinics in primary care, medical oncology, sports medicine, cardiology, and endocrinology. We gathered initial information to identify requirements and assess workflow to iteratively develop the qPCM with two rounds of interviews with clinical scenarios and the System Usability Scale (SUS). We assessed barriers and facilitators of assessing falls risk and of using qPCM and modified the qPCM after each round. </sec> <sec> <title>RESULTS</title> Eighteen clinicians participated in both rounds of formative evaluation. Some physical attributes of the device and patient characteristics created barriers as well as facilitators for use of the device. Participants reported willingness to use the device with all patients during the first round of interviews and reported they would replace their current weight scale with the modified device during the second round of interviews. SUS scores were 83.6/100 after the first round and 86.8/100 after the second round. Several barriers to an evidence-based assessment of falls risk were identified including lack of knowledge regarding national guidelines and lack of consistent training. </sec> <sec> <title>CONCLUSIONS</title> The quantitative postural control measurement tool device provides a new method for quantifying falls risk with good user acceptance and usability and feasibility in a clinic environment without disrupting the workflow. The qPCM measurements supplemented and facilitated use of standard algorithms for falls risk assessment. Providers described qPCM as useful to more definitively identify people at risk of falls. Greater education of the entire care team regarding evidence-based falls risk assessments could promote adherence and fall prevention. </sec> <sec> <title>CLINICALTRIAL</title> clinicaltrials.gov/ct2/show/NCT04139642 </sec>
Effect of changing beta-blocker treatment in six patients allergic to timolol (1987)

We evaluated the tolerance of topical 0.5 % levobunolol in six patients with bilateral, open-angle glaucoma, who had developed signs of local irritation and allergy while receiving 0.5% timolol, twice daily. During treatment with levobunolol, four of the six patients did not experience an allergic reaction. Levobunolol successfully controlled intraocular pressure in all six patients.
Cancer risk among users of neuroleptic medication: a population-based cohort study (2006)

It has been suggested that neuroleptic medication may decrease cancer risk. We compared cancer risks in a population-based cohort study of 25,264 users (>or=2 prescriptions) of neuroleptic medications in the county of North Jutland, Denmark, during 1989-2002, with that of county residents who did not receive such prescriptions. Statistical analyses were based on age-standardisation and Poisson regression analysis, adjusting for age, calendar period, COPD, liver cirrhosis or alcoholism, use of NSAID, and, for breast cancer, additionally for use of hormone therapy, age at first birth, and number of children. Use of neuroleptic medications was associated with a decreased risk for rectal cancer in both women and men (adjusted IRRs of 0.61 (95% confidence interval, 0.41-0.91) and 0.82 (0.56-1.19), respectively) and for colon cancer in female users (0.78; 0.62-0.98). Some risk reduction was seen for prostate cancer (0.87; 0.69-1.08), but breast cancer risk was close to unity (0.93; 0.74-1.17). Overall, treatment with neuroleptic medications was not related to a reduced risk of cancer, but for cancers of the rectum, colon and prostate there were suggestive decreases in risk.
X-ray guided robotic radiosurgery for solid tumors (2002)

This paper presents an overview of the X-ray guided robotic radiosurgery system that has been developed for the ablation of solid tumors. A robot mounted linear accelerator is directed through a sequences of positions and orientations designed to deliver high radiation dosages at specific locations. Patient movement during treatment is identified by stereo X-ray measurements and the robotic system adjusts the linear accelerator prior to the delivery of radiation at each location. The result is precise delivery with rigid registration of the tumor relative to the treatment system.
ChemInform Abstract: Azaparacyclophanes with Metal‐Binding Sites. Part 1. Preparation, Characterization, and Molecular Recognition Behavior of Hexapus Azaparacyclophane and Its Iron(III) Complex. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nucleosides. 130. Synthesis of 2′‐Deoxy‐2′‐substituted‐ and 5′‐Deoxy‐5′‐substituted‐ψ‐uridine Derivatives. Crystalline and Molecular Structure of 2′‐Chloro‐2′‐deoxy‐1,3‐dimethyl‐ψ‐uridine. Studies Directed Toward the Synthesis of 2′‐Deoxy‐2′‐substituted‐arabino‐Nucleosides. 1 (1985)

Abstract A method was developed to prepare 5′‐deoxy‐5′‐substituted‐ψ‐uridine derivatives 4 from 3′,5′‐ O ‐(1, 1, 3, 3‐tetraisopropyldisiloxanyl)‐1,3‐dimethyl‐ψ‐uridine 1 via a silyl rearrangement reaction. Nucleophilic displacement of the mesyloxy function of 2′‐ O ‐mesyl‐1,3‐dimethyl‐ψ‐uridine 7 afforded products with the 2′‐substituent in the “down” ribo configuration 8 . X‐Ray crystallographic analysis of the 2′‐chloro derivative 8a firmly established the molecular structure of 8 and provided evidence for neighboring group participation of the 4‐carbonyl function of 7 during the nucleophilic reactions. Treatment of 1,3‐dimethyl‐ψ‐uridine 11 with α‐acetoxyisobutyryl chloride afforded a mixture from which two 2′‐chloro‐2′‐deoxy‐ C ‐nucleosides were obtained. The major product (33% yield) was identical with 8 . The minor product (7% yield) was consequently assigned the arabino nucleoside 14 . This is the first direct introduction of a 2′‐substituent in the “up” configuration in a preformed pyrimidine nucleoside.
Trial-in-progress: A pilot study of combined immune checkpoint inhibition in combination with ablative therapies in subjects with hepatocellular carcinoma (HCC). (2021)

TPS355 Background: Locoregional therapies for hepatocellular carcinoma, such as transcatheter arterial chemoembolization (TACE) or ablation, can induce a peripheral anti-tumor immune response. This may be amplified by immune checkpoint inhibitors (ICI). Early and higher anti-CTLA4 dosing could potentially lead to better priming and a stronger immune response. Recent data has suggested that early (day 1 only), increased doses of anti-CTLA4 therapy, was associated with encouraging clinical activity and a tolerable safety profile. This study will evaluate dual immune checkpoint, CTLA4 (tremelimumab, day 1-only dosing) and PD-L1 (durvalumab) blockade in combination with TACE in patients with advanced HCC. Intensive peripheral immune-monitoring and longitudinal on-treatment tumor biopsies will focus on the role of the innate immune system, particularly Natural Killer cells, in anti-tumor responses. Methods: Patients with HCC (Childs Pugh A/B7; Barcelona Clinic Liver Cancer Stage B/C; ECOG 0/1; sorafenib-naïve or experienced) are being enrolled in a pilot study (Study Number UCDCRC/19/01) of tremelimumab at 2 dose levels (DL1 and DL2) in combination with durvalumab and TACE until disease progression (per irRECIST). DL1: tremelimumab (75mg q28 days for 4 doses) and durvalumab (1500mg q28 days). DL2: tremelimumab (300mg in a single dose on day 1) and durvalumab (1500mg q28 days). Subtotal TACE will be performed during study week 6 with the dose-limiting toxicity (DLT) evaluation period encompassing the first 8 weeks of the study. Primary endpoint is 6-month progression-free survival with secondary efficacy endpoints being safety, tolerability and overall survival. Exploratory objectives will evaluate changes in immune parameters in the tumor and peripheral blood of patients undergoing anti-CTLA4 therapy pre- and post-RFA or TACE. A major focus will be on the role of the innate immune system, particularly Natural Killer cells, in anti-tumor responses. Patients will be enrolled and treated at St Vincent’s University Hospital in Dublin, Ireland. This study is currently open and actively recruiting. Clinical trial information: EudraCT Number 2019-002767-98.
Learning Shape Abstractions by Assembling Volumetric Primitives (2016)

We present a learning framework for abstracting complex shapes by learning to assemble objects using 3D volumetric primitives. In addition to generating simple and geometrically interpretable explanations of 3D objects, our framework also allows us to automatically discover and exploit consistent structure in the data. We demonstrate that using our method allows predicting shape representations which can be leveraged for obtaining a consistent parsing across the instances of a shape collection and constructing an interpretable shape similarity measure. We also examine applications for image-based prediction as well as shape manipulation.
Optimization of liquid crystal devices based on weakly conductive layers for lensing and beam steering (2017)

Liquid crystals are mostly known for their use in displays, but over the past decade these materials have been applied in a number of other devices such as tunable lenses or beam steering devices. A common technique to realize a gradual electric field profile as is required to obtain a gradual refractive index profile in these applications is the use of weakly conductive materials. The weakly conductive layers are able to spread the voltage profile which is applied through well-conductive electrodes at the side of the weakly conductive layer. The simulation and design of such structures is not trivial because two or three dimensional quasi-static electric field profiles need to be calculated. This is due to the fact that the resistivity of the conductive layers and the dielectric properties of the liquid crystal are coupled. An exact solution requires solving a number of coupled differential equations. In this paper, we develop a model to simulate the RC-effects with an approximate model.
Identification of RCC1- LCK as a novel fusion gene in pediatric erythroid sarcoma (2022)

Erythroid sarcoma is very rare form of pure erythroid leukemia with undetermined biological features. Here, we present an infant with a multifocal erythroid sarcoma, diagnosed because the tumor cells were positive for glycophorin A. After acute myeloid leukemia-oriented chemotherapy and surgical resection followed by cord blood transplantation, he has successfully maintained complete remission without any late effects. Total transcriptome analysis of the tumor identified a novel fusion gene, RCC1-LCK, and high LCK expression levels, suggesting that LCK overexpression was involved in leukemogenesis in this case.
Molecular dynamics simulation of the domain size effect on the values of thermal conductivity of long chain n-alkanes (2015)

Phase change materials such as n-alkanes that possess desirable characteristics such as high latent heat, chemical stability and negligible supercooling are widely used in thermal energy storage applications. However, n-alkanes have the drawback of low thermal conductivity values. Understanding the thermal transport phenomena associated with n-alkane such as n-eicosane (C20H42) and triacontane (C30H62) is crucial for improving the efficiency of thermal storage systems. In this paper, the thermal conductivity of long chain n-alkanes (C20H42, C24H50, C26H54 and C30H62) is investigated by utilizing non-equilibrium molecular dynamics (NEMD) simulations. The main challenge in this work is to remove the possible domain size effect from the existing data for solid n-alkanes. Thus, the effect of the cross section of the system is studied. We utilized three different numbers of molecules for the case of C30H62 to investigate the effect of the size effect due to the cross section area. Results confirm that the 600 number of molecules being used for the simulation box is sufficient to remove the size effect. All simulations were performed with the large-scale atomic/molecular massively parallel simulator (LAMMPS) molecular dynamics package.
Artificial neural networks based techniques for anomaly detection in Apache Spark (2019)

Abstract Late detection and manual resolutions of performance anomalies in Cloud Computing and Big Data systems may lead to performance violations and financial penalties. Motivated by this issue, we propose an artificial neural network based methodology for anomaly detection tailored to the Apache Spark in-memory processing platform. Apache Spark is widely adopted by industry because of its speed and generality, however there is still a shortage of comprehensive performance anomaly detection methods applicable to this platform. We propose an artificial neural networks driven methodology to quickly sift through Spark logs data and operating system monitoring metrics to accurately detect and classify anomalous behaviors based on the Spark resilient distributed dataset characteristics. The proposed method is evaluated against three popular machine learning algorithms, decision trees, nearest neighbor, and support vector machine, as well as against four variants that consider different monitoring datasets. The results prove that our proposed method outperforms other methods, typically achieving 98–99% F-scores, and offering much greater accuracy than alternative techniques to detect both the period in which anomalies occurred and their type.
Prostatein (or rat prostatic steroid binding protein) is a major autoantigen in experimental autoimmune prostatitis (1998)

Experimental autoimmune prostatitis (EAP) is a disease that could be considered an experimental model of human non-bacterial prostatitis. In this experimental model, male rats are intradermally immunized with a saline extract of male sex accessory glands (RAG) in an adequate adjuvant. The prostatitis observed in the immunized animals develops as a consequence of the immune response against RAG antigens, and the histological lesion is strikingly similar to the pattern of prostatic inflammation observed in the human disease. In this study, we purified one of the prostatic autoantigens recognized by the autoantibodies in our model. Amino acid sequence analysis identified the purified protein as prostatein or rat prostatic steroid binding protein, a member of the uteroglobin superfamily. Prostatein was recognized not only by the humoral autoimmune response, but also by the cellular autoimmune response. Certainly, the DTH response and lymph node cell proliferative assays against prostatein in immunized animals yielded positive results. Prostatein is not only the target of the autoimmune response in animals immunized with the whole extract, but also an inducing antigen of the disease. Purified prostatein, when incorporated to an adequate adjuvant, elicited cellular and humoral autoimmune response and lesion in the prostate gland. The identification of one of the target antigens in autoimmune prostatitis has provided a further refinement and characterization of our model, which could serve for a better understanding of the aetiology, pathogenesis and pathophysiology of non-bacterial prostatitis.
Space Station Microscopy: Beyond the Box (1993)

&lt;div class="htmlview paragraph"&gt;Microscopy aboard Space Station Freedom poses many unique challenges for in-flight investigations. Disciplines such as materials processing, plant and animal research, human research, environmental monitoring, health care, and biological processing have diverse microscope requirements. The typical microscope not only does not meet the comprehensive needs of these varied users, but also tends to require excessive crew time. To assess user requirements, a comprehensive survey was conducted among investigators with experiments requiring microscopy. The survey examined requirements such as light sources, objectives, stages, focusing systems, eye pieces, video accessories, etc. The results of this survey and the application of an Intelligent Microscope Imaging System (IMIS) may address these demands for efficient microscopy service in space. The proposed IMIS can accommodate multiple users with varied requirements, operate in several modes, reduce crew time needed for experiments, and take maximum advantage of the restrictive data/instruction transmission environment on Freedom.&lt;/div&gt;
Au2O3 as a Stable and Efficient Catalyst for the Selective Cycloisomerization of γ-Acetylenic Carboxylic Acids to γ-Alkylidene-γ-Butyrolactones (2008)

International audience
Chair and twist-boat conformations of 1,3-dioxanes: limitations of molecular mechanics force fields (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChair and twist-boat conformations of 1,3-dioxanes: limitations of molecular mechanics force fieldsScott D. Rychnovsky, Guang Yang, and Jay P. PowersCite this: J. Org. Chem. 1993, 58, 19, 5251–5255Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/jo00071a040https://doi.org/10.1021/jo00071a040research-articleACS PublicationsRequest reuse permissionsArticle Views458Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Data from Irinotecan Pharmacogenetics: Influence of Pharmacodynamic Genes (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Irinotecan is an important drug for the treatment of solid tumors. Although genes involved in irinotecan pharmacokinetics have been shown to influence toxicity, there are no data on pharmacodynamic genes. &lt;i&gt;CDC45L, NFKB1, PARP1, TDP1&lt;/i&gt;, and &lt;i&gt;XRCC1&lt;/i&gt; have been shown to influence the cytotoxic action of camptothecins, including irinotecan. Polymorphisms in the drug target of camptothecins, topoisomerase I (&lt;i&gt;TOP1&lt;/i&gt;), and downstream effectors may influence patient outcomes to irinotecan therapy. We undertook a retrospective candidate gene haplotype association study to investigate this hypothesis.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Haplotype compositions of six candidate genes were constructed in European (&lt;i&gt;n&lt;/i&gt; = 93), East Asian (&lt;i&gt;n&lt;/i&gt; = 94), and West African (&lt;i&gt;n&lt;/i&gt; = 95) populations. Haplotype-tagging single nucleotide polymorphisms (htSNP) were selected based on genealogic relationships between haplotypes. DNA samples from 107 European, advanced colorectal cancer patients treated with irinotecan-based regimens were genotyped for htSNPs as well as three coding region SNPs. Associations between genetic variants and toxicity (grade 3/4 diarrhea and neutropenia) or efficacy (objective response) were assessed.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt;&lt;i&gt;TOP1&lt;/i&gt; and &lt;i&gt;TDP1&lt;/i&gt; htSNPs were related to grade 3/4 neutropenia (&lt;i&gt;P&lt;/i&gt; = 0.04) and response (&lt;i&gt;P&lt;/i&gt; = 0.04), respectively. Patients homozygous for an &lt;i&gt;XRCC1&lt;/i&gt; haplotype (GGCC-G) were more likely to show an objective response to therapy than other patients (83% versus 30%; &lt;i&gt;P&lt;/i&gt; = 0.02). This effect was also seen in a multivariate analysis (odds ratio, 11.9; &lt;i&gt;P&lt;/i&gt; = 0.04). No genetic variants were associated with diarrhea.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; This is the first comprehensive pharmacogenetic investigation of irinotecan pharmacodynamic factors, and our findings suggest that genetic variation in the pharmacodynamic genes may influence the efficacy of irinotecan-containing therapies in advanced colorectal cancer patients.&lt;/p&gt;&lt;/div&gt;