gebhart/patrepeval huggingface dataset:
Lack of Ephrin Receptor A1 Is a Favorable Independent Prognostic Factor in Clear Cell Renal Cell Carcinoma (2014)

The EPH receptor tyrosine kinases and their cell-bound ligands, the ephrins, have been shown to be associated with cancer development and progression. In this study, mRNA and protein expression of the receptors EPHA1 and EPHA2 as well as of their ligand EFNA1 and their prognostic relevance in clear cell renal cell carcinoma was evaluated. Gene expression was measured in 75 cryo-preserved primary tumors and matched non-malignant renal specimens by quantitative PCR. Protein expression was analyzed by immunohistochemistry on tissue microarrays comprising non-malignant, primary tumors and metastatic renal tissues of 241 patients. Gene and protein expression of all three factors was altered in tumor specimens with EPHA1 and EPHA2 being generally diminished in tumors compared to normal renal tissue, whereas EFNA1 was commonly elevated. A positive EPHA1 and EPHA2 protein staining as well as a low EFNA1 protein level were significantly linked to more aggressive tumor features, but only a positive EPHA1 immunoreactivity was significantly associated with poor survival. In subgroup analyses, EPHA1 and EPHA2 protein levels were significantly higher in metastatic than in primary lesions. Patients with EPHA1/EPHA2-positive tumors or with tumors with positive EPHA1 and low EFNA1 immunoreactivity had the shortest survival rates compared to the respective other combinations. In a multivariate model, EPHA1 was an independent prognostic marker for different survival endpoints. In conclusion, an impaired EPH-ephrin signaling could contribute to the pathogenesis and progression of clear cell renal cell carcinoma.
One Abutment at One Time Concept for Platform-Switched Morse Implants: Systematic Review and Meta-Analysis (2017)

The aim of this systematic review and meta-analysis was to compare the peri-implant vertical bone loss of immediate loading of implant crowns using the one abutment at one time (AOT) protocol and implants with abutment removal (AR). This systematic review with meta-analysis was reported according to the PRISMA statement, with guidance from the Cochrane Collaboration Handbook. A total of 103 publications were identified in the PubMed database and reference lists of examined articles. After the screening of titles and abstracts, the eligibility of eight full-text articles was assessed. Five studies published between 2010 and 2015 were included in the meta-analysis. There was less peri-implant vertical bone loss at implants using an AOT protocol than at implants using AR protocol (WMD -0.19, 95% CI -0.26 to -0.13; p<0.0001; random-effects model). In conclusion, the use of the AOT protocol with platform-switched Morse implants results in less bone loss than do AR procedures, but this effect may not be clinically relevant. The preservation of marginal bone level achieved with the AOT protocol may not enhance the aesthetics. These results should be interpreted with caution.
Kayak image fusion sequence (2014)

Here we present part I of the multimodal Kayak image dataset consisting of two image sequences showing three approaching kayaks in a cluttered maritime background. The scenario was registered in the 3-5 mm (mid-wave infrared), and 8-12 mm (long wave infrared or thermal) frequency bands and in the visual range. Because of the variation in distance the targets (kayaks) vary from dim point targets to easily distinguishable objects. This dataset can be used to develop and test mulisensor image fusion schemes and dim target detection algorithms.
A transparent light-weight group service (2002)

The virtual synchrony model for group communication has proven to be a powerful paradigm for building distributed applications. Implementations of virtual synchrony usually require the use of failure detectors and failure recovery protocols. In applications that require the use of a large number of groups, significant performance gains can be attained if these groups share the resources required to provide virtual synchrony. A service that maps user groups onto instances of a virtually synchronous implementation is called a light-weight group service. This paper proposes a new design for the light-weight group protocols that enables the usage of this service in a transparent manner as a test case, the new design was implemented in the Horus system, although the underlying principles can be applied to other architectures as well. The paper also presents performance results from this implementation.
Histological coherent Raman imaging: a prognostic review (2017)

Histopathology plays a central role in diagnosis of many diseases including solid cancers. Efforts are underway to transform this subjective art to an objective and quantitative science. Coherent Raman imaging (CRI), a label-free imaging modality with sub-cellular spatial resolution and molecule-specific contrast possesses characteristics which could support the qualitative-to-quantitative transition of histopathology. In this work we briefly survey major themes related to modernization of histopathology, review applications of CRI to histopathology and, finally, discuss potential roles for CRI in the transformation of histopathology that is already underway.
Prediction of far-field acoustic emissions from cavitation clouds during shock wave lithotripsy for development of a clinical device (2012)

Abstract This study presents the key simulation and decision stage of a multi-disciplinary project to develop a hospital device for monitoring the effectiveness of kidney stone fragmentation by shock wave lithotripsy (SWL). The device analyses, in real time, the pressure fields detected by sensors placed on the patient's torso, fields generated by the interaction of the incident shock wave, cavitation, kidney stone and soft tissue. Earlier free-Lagrange simulations of those interactions were restricted (by limited computational resources) to computational domains within a few centimetres of the stone. Later studies estimated the far-field pressures generated when those interactions involved only single bubbles. This study extends the free-Lagrange method to quantify the bubble–bubble interaction as a function of their separation. This, in turn, allowed identification of the validity of using a model of non-interacting bubbles to obtain estimations of the far-field pressures from 1000 bubbles distributed within the focus of the SWL field. Up to this point in the multi-disciplinary project, the design of the clinical device had been led by the simulations. This study records the decision point when the project's direction had to be led by far more costly clinical trials instead of the relatively inexpensive simulations.
Redesign of a Spatial Gear Pair Using Configuration Spaces (2002)

This paper presents an industrial case study in which a spatial higher pair is redesigned using our configuration space method of kinematic analysis. The task is to remove occasional blocking in an asynchronous reverse gear pair from a car transmission. A systematic kinematic analysis is required because the blocking configurations are unknown and because very few initial configurations cause blocking. We use our configuration space method of kinematic analysis to solve the problem. We determine why the gears block by constructing a series of two-dimensional configuration spaces that model the engagement kinematics. Blocking occurs when two consecutive pairs of teeth make contact during engagement. The gear angles at the contact determine whether or not the gears will block. Our analysis determines that blocking occurs in 4% of the angle space. Fine tuning the gear parameters reduces the range to 0.5%, but cannot eliminate the blocking. Removing every second gear tooth eliminates the blocking. The analysis results are consistent with the experimental data. The case study demonstrates that the configuration space method helps solve industrial problems that are outside the scope of prior work.
Prediction of Residual Curing Capacity of Melamine-Formaldehyde Resins at an Early Stage of Synthesis by In-Line FTIR Spectroscopy (2021)

Melamine-formaldehyde (MF) resins are widely used as surface finishes for engineered wood-based panels in decorative laminates. Since no additional glue is applied in lamination, the overall residual curing capacity of MF resins is of great technological importance. Residual curing capacity is measured by differential scanning calorimetry (DSC) as the exothermic curing enthalpy integral of the liquid resin. After resin synthesis is completed, the resulting pre-polymer has a defined chemical structure with a corresponding residual curing capacity. Predicting the residual curing capacity of a resin batch already at an early stage during synthesis would enable corrective measures to be taken by making adjustments while synthesis is still in progress. Thereby, discarding faulty batches could be avoided. Here, by using a batch modelling approach, it is demonstrated how quantitative predictions of MF residual curing capacity can be derived from inline Fourier Transform infrared (FTIR) spectra recorded during resin synthesis using partial least squares regression. Not only is there a strong correlation (R<sup>2</sup> = 0.89) between the infrared spectra measured at the end of MF resin synthesis and the residual curing capacity. The inline reaction spectra obtained already at the point of complete dissolution of melamine upon methylolation during the initial stage of resin synthesis are also well suited for predicting final curing performance of the resin. Based on these IR spectra, a valid regression model (R<sup>2</sup> = 0.85) can be established using information obtained at a very early stage of MF resin synthesis.
Memristor-The missing circuit element (1971)

A new two-terminal circuit element-called the memristorcharacterized by a relationship between the charge <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">q(t)\equiv \int_{-\infty}^{t} i(\tau) d \tau</tex> and the flux-linkage <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\varphi(t)\equiv \int_{- \infty}^{t} v(\tau) d \tau</tex> is introduced as the fourth basic circuit element. An electromagnetic field interpretation of this relationship in terms of a quasi-static expansion of Maxwell's equations is presented. Many circuit-theoretic properties of memistors are derived. It is shown that this element exhibits some peculiar behavior different from that exhibited by resistors, inductors, or capacitors. These properties lead to a number of unique applications which cannot be realized with <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">RLC</tex> networks alone. Although a physical memristor device without internal power supply has not yet been discovered, operational laboratory models have been built with the help of active circuits. Experimental results are presented to demonstrate the properties and potential applications of memristors.
Miniaturized long period grating sensor interrogator based on a thermally tunable arrayed-waveguide-grating demultiplexer (2008)

A wavelength interrogation system based on an arrayed-waveguide-grating (AWG) is evaluated. The transmission wavelengths are capable of shifting by thermally scanning the AWG. By employing this AWG wavelength tunability scheme, the center wavelength of a long-period-grating (LPG) sensor is precisely interrogated. The theoretical principle and the experimental result are presented in this paper. An interrogated wavelength resolution of 0.5 pm is achieved by introducing this technique. Furthermore, a palm-size LPG sensor interrogator based on a chip integrated with an AWG demultiplexer, a photodiode, a signal processing module and an electronic controlling module is proposed.
Storage Temperature and 1-Methylcyclopropene Treatment Affect Storage Disorders and Physiological Attributes of ‘Royal Gala’ Apples (2016)

‘Royal Gala’ apples [ Malus domestica (Borkh.) Mansf.]can develop postharvest disorders such as flesh browning, senescent breakdown, peeling, cracking, or shriveling during and after cold storage. The objective of this study was to examine the effects of storage temperature and a range (0, 0.25, 0.5, or 1 µL·L −1 ) of 1-methylcyclopropene (1-MCP) concentrations on fruit quality attributes and incidence and severity of physiological disorders during and after cold storage. Storage temperature differentially affected internal ethylene concentration (IEC), fruit circumference, and cortex color. 1-MCP treatment resulted in significant effects on fruit quality attributes and severity of physiological disorders, regardless of storage temperature. Incidence and severity of diffuse flesh breakdown (DFB), shriveling, cracking, and peeling were highest in control fruit stored but radial stem-end flesh breakdown (RSFB) only primarily in 1-MCP-treated fruit. Incidence of RSFB was highest following storage at 0.5 °C compared with 3 °C. 1-MCP treatment had the most influence on disorder incidence/severity or quality attributes, while treatment concentration of 1-MCP was not significant. Overall, the results indicate that 1-MCP treatment can reduce the incidence of ‘Royal Gala’ DFB but may enhance sensitivity to RSFB, when fruit are stored at 0.5 or 3 °C. Incidence of DFB and RSFB are influenced differentially by storage temperature or by 1-MCP treatment, respectively, indicating they may be different disorders.
Approximations to α for diffusion transistors (1959)

The paper reviews, from the viewpoint of design engineers, various approximations to the common-base intrinsic current gain of junction transistors. The basis of this comparison is the familiar expression for α derived directly from the semiconductor diffusion and continuity equations.A 2-pole approximation is considered in detail. It is shown that both the sinusoidal and transient response predicted using this expression is in good agreement with that predicted using the exact theory. For most practical transistors the parameters of this approximation remain reasonably constant.In the response to a step function of emitter current, the 2-pole equation closely describes the initial time delay arising from the transit time of minority carriers across the base region. The collector response to unit charge inserted into the base in the form of σ function also gives good agreement with the results obtained from the exact theory.The various approximations are compared by graphical presentation of the results.
The roles of c‐Jun NH2‐terminal kinases (JNKs) in obesity and insulin resistance (2015)

Obesity is currently at epidemic levels worldwide and is associated with a wide range of diseases such as type 2 diabetes, cardiovascular disease, fatty liver disease and certain forms of cancer. Obesity-induced chronic inflammation is central to the disrupted metabolic homeostasis which underlies many of these conditions. While research over the past decade has identified many of the cells and signalling molecules that contribute to obesity-induced inflammation, perhaps the best characterised are the stress-activated c-Jun NH2 -terminal kinases (JNKs). JNKs are activated in obesity in numerous metabolically important cells and tissues such as adipose tissue, macrophages, liver, skeletal muscle and regions of the brain and pituitary. Elegant in vivo mouse studies using Cre-LoxP-mediated recombination of the JNK1 and JNK2 genes have revealed the remarkably diverse roles that JNKs play in the development of obesity-induced inflammation, impaired glucose homeostasis and hepatic steatosis. While JNK activation in classical metabolically active tissues such as skeletal muscle and adipose tissue only appears to play a minor role on the induction of the above-mentioned pathologies, recent studies have clearly established the important roles JNK signalling fulfils in macrophages, the liver and cells of the anterior pituitary. Collectively, these studies place JNKs as important mediators of obesity and obesity-associated disruptions to metabolic homeostasis.
Electrochemical and anti‐corrosion behaviors of water dispersible graphene/acrylic modified alkyd resin latex composites coated carbon steel (2016)

ABSTRACT A type of water dispersible graphene (PG) has been synthesized by nucleophilic ring‐opening reaction of the primary amine group in 3‐(1‐(2‐aminopropoxy) propan‐2‐ylamino) propane‐1‐sulfonate sodium (PPS) with epoxy groups on the basal plane of graphene oxide (GO), followed by in situ reduction with hydrazine hydrate. The PG is employed as nanoscale reinforcement fillers in waterborne acrylic modified alkyd resin (AMAR) coatings. The stability and corrosion resistance of the waterborne PG/AMAR nanocomposite coatings are investigated. SEM and stability of nanocomposite indicated that the PG sheet is uniformly distributed in AMAR nano‐emulsion. Potentiodynamic polarization and electrochemical impedance spectroscopy studies indicated that the PG/AMAR composite coatings exhibit higher corrosion resistance in simulated body fluid (SBF) compared with pure AMAR coatings and GO/AMAR coatings. In addition, the stability and corrosion resistance of the composite materials reach optimum when the PG content is 1%. PPS functionalized graphene (PG) displays prospective application in anticorrosion field. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44445.
Modulation of release kinetics by plasma polymerization of ampicillin-loaded β-TCP ceramics (2016)

Abstract Beta-tricalcium phosphate ( β -TCP) bioceramics are employed in bone repair surgery. Their local implantation in bone defects puts them in the limelight as potential materials for local drug delivery. However, obtaining suitable release patterns fitting the required therapeutics is a challenge. Here, plasma polymerization of ampicillin-loaded β -TCP is studied for the design of a novel antibiotic delivery system. Polyethylene glycol-like (PEG-like) coating of β -TCP by low pressure plasma polymerization was performed using diglyme as precursor, and nanometric PEG-like layers were obtained by simple and double plasma polymerization processes. A significant increase in hydrophobicity, and the presence of plasma polymer was visible on the surface by SEM and quantified by XPS. As a main consequence of the plasma polymerisation, the release kinetics were successfully modified, avoiding burst release, and slowing down the initial rate of release leading to a 4.5 h delay in reaching the same antibiotic release percentage, whilst conservation of the activity of the antibiotic was simultaneously maintained. Thus, plasma polymerisation on the surface of bioceramics may be a good strategy to design controlled drug delivery matrices for local bone therapies.
EBV‐determined nuclear antigen (EBNA)‐positive cells in the peripheral blood of infectious mononucleosis patients (1976)

Abstract After removal of SRBC rosette‐forming T‐cells from the peripheral blood, the residual, largely B‐lymphocyte fractin of five infectious mononucleosis patients was found no contain 0.5‐2% blast cells, positive for the EBV‐determined nuclear antigen (EBNA). There was a rough parallelism between the presence of large lymphoblasts in the hematological smear, EBNA‐positive large blasts in the B‐cell fraction and the ability of the T‐cell fraction to expert an EBV‐specific lymphocytotoxicity on established cell lines in vitro. EBNA‐positive B‐cells and EBV‐specific killer T‐cells disappeared after the acute phase of the disease.
Photoswitchable Supramolecular Catalysis by Interparticle Host–Guest Competitive Binding (2012)

On and off: Ester hydrolysis catalyzed by a ZnII-coordinated β-cyclodextrin dimer can be switched on and off using light in the presence of gold nanoparticles with azobenzene units attatched to their surfaces. Under visible light, the azobenzene units are trans and bind tightly to the dimer, thus leading to reduced catalysis. Under UV light, the azobenzene units are cis and bind loosely to the dimer, thus allowing substrates to bind and hydrolysis to occur. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Synthesis of Optically Active Oligonaphthalenes via Second-Order Asymmetric Transformation (2003)

Synthesis of numerous optically active rod-shaped oligo(2,3-dioxyfunctionalized)naphthalenes connected at their 1,4-positions was achieved using oxidative coupling under CuCl2/alpha-methylbenzylamine conditions by second-order asymmetric transformation. We believe this method is practical and should contribute to the field of material science.
Measuring children's independent mobility: comparing interactive mapping with destination access and licence to roam (2017)

International audience
Generalized secret sharing and group-key distribution using short keys (2002)

We relate two basic primitives: generalized secret sharing and group-key distribution. We suggest cryptographic implementations for both and show that they are provably secure according to exact definitions and assumptions given in the present paper. Both solutions require small secret space (namely, short keys). We first consider secret sharing with arbitrary access structures which is a basic primitive for controlling retrieval of secret information. We consider the computational security model, where cryptographic assumptions are allowed. Our design of a general secret-sharing scheme requires considerably less secure memory (i.e., shorter keys) than before. We then introduce the notion of a (single source) group-key distribution protocol which allows a center in an integrated network to securely and repeatedly send different keys to different groups. Such a capability is of increasing importance as it is a building block for secret information dissemination to various groups of participants in the presence of eavesdropping in a network environment. There are only a few previous investigations concerning this primitive and they either require a large amount of storage of secret information (due to their information theoretic security model) or lack rigorous definitions and proofs of security. We base both primitives on pseudo-random functions. We prove that the two are related; we give a reduction showing that group-key distribution implies secret-sharing under pseudo-random functions (i.e., one-way functions).
An Analytical Model of Leakage Neutron Equivalent Dose for Passively-Scattered Proton Radiotherapy and Validation with Measurements (2015)

Exposure to stray neutrons increases the risk of second cancer development after proton therapy. Previously reported analytical models of this exposure were difficult to configure and had not been investigated below 100 MeV proton energy. The purposes of this study were to test an analytical model of neutron equivalent dose per therapeutic absorbed dose at 75 MeV and to improve the model by reducing the number of configuration parameters and making it continuous in proton energy from 100 to 250 MeV. To develop the analytical model, we used previously published H/D values in water from Monte Carlo simulations of a general-purpose beamline for proton energies from 100 to 250 MeV. We also configured and tested the model on in-air neutron equivalent doses measured for a 75 MeV ocular beamline. Predicted H/D values from the analytical model and Monte Carlo agreed well from 100 to 250 MeV (10% average difference). Predicted H/D values from the analytical model also agreed well with measurements at 75 MeV (15% average difference). The results indicate that analytical models can give fast, reliable calculations of neutron exposure after proton therapy. This ability is absent in treatment planning systems but vital to second cancer risk estimation.