gebhart/patrepeval huggingface dataset:
DISCRIMINANT ANALYSIS OF HYPERSPECTRAL DATA FOR ASSESSING WATER AND NITROGEN STRESSES IN COR (2005)

The development and implementation of both economically and environmentally sustainable precision cropmanagement systems can be greatly enhanced through the use of remote sensing. In this study, the potential ofnarrow-waveband hyperspectral observations in the discrimination of nitrogen and water stresses in corn (Zea mays L.) wasinvestigated. A field experiment was conducted in the summer of 2002 at the Macdonald Research Farm, McGill University,Ste-Anne-de-Bellevue, Quebec, Canada. Corn was grown in forty 9.0 10.0 m test plots laid out in a split-plot design withirrigation (non-irrigated, irrigated) as the main treatment and nitrogen fertilizer application rate (50, 100, 150, 200, and250 kg ha-1) as the sub-treatment. Hyperspectral measurements in 2151 wavebands (350 to 2500 nm) were made with a fieldspectroradiometer during the entire growing season. Using a stepwise procedure, the most effective wavebands capable ofdiscriminating treatment effects were selected. By applying a discrimination procedure with a well-chosen subset of theselected wavebands, treatments were correctly classified with more than 95% accuracy. Specific narrow wavebands, fromdifferent portions of the spectrum, allowed the discrimination of plots differing in their irrigation and nitrogen treatments.This study supports past work suggesting that greater spectral resolution should lead to more consistent relationships betweenthe spectral data and different crop status indicators.
CEACAM1 in Malignant Melanoma: A Diagnostic and Therapeutic Target (2012)

CEACAM1 adhesion molecule is broadly expressed, participates in pivotal cellular and immunological processes and is involved in cancer. Originally identified as a tumor suppressor, it is now known that in several cancers, including malignant melanoma, CEACAM1 expression correlates with tumor progression and poor survival. Here we review the findings connecting CEACAM1 to malignant melanoma, encompassing in-vitro, in-vivo and patients-derived data. A CEACAM1-mediated mechanism used by melanoma cells to evade immune attack is described in detail. Finally, the potential value of CEACAM1 as a melanoma biomarker and therapeutic target is being discussed.
Intracellular levels of the LIS1 protein correlate with clinical and neuroradiological findings in patients with classical lissencephaly (1999)

We report on the genotype–phenotype correlation in 7 patients with classical lissencephaly carrying a heterozygous subtle mutation in the LIS1 gene. Six patients showed a mutation predicted to encode for a truncated protein, and one mutation altered a splicing site, resulting in skipping of exon 4. Western blot analysis performed on the lymphoblastoid cell line of 2 patients bearing truncating mutations indicated that the mutated allele did not produce a detectable amount of the LIS1 protein; whereas the analysis performed on the fibroblasts from the patient with a splice-site mutation was suggestive of partial protein synthesis from the mutated allele. Although clinical and magnetic resonance imaging findings of patients with truncating mutations did not differ from those observed in patients with a heterozygous deletion, the patient bearing the exon-skipping mutation had less severe clinical and brain involvement. Our data suggest that truncating mutations in the LIS1 gene are relatively common among patients with classical lissencephaly not bearing a heterozygous deletion at 17p13.3, and strengthen the relevance of correct intracellular dosage of the LIS1 protein in the neuronal migration process. Ann Neurol 1999;45:154–161
Central Obesity as a Precursor to the Metabolic Syndrome in the AusDiab Study and Mauritius (2008)

Evidence from epidemiologic studies that central obesity precedes future metabolic change and does not occur concurrently with the appearance of the blood pressure, glucose, and lipid abnormalities that characterize the metabolic syndrome (MetS) has been lacking. Longitudinal surveys were conducted in Mauritius in 1987, 1992, and 1998, and in Australia in 2000 and 2005 (AusDiab). This analysis included men and women (aged > or = 25 years) in three cohorts: AusDiab 2000-2005 (n = 5,039), Mauritius 1987-1992 (n = 2,849), and Mauritius 1987-1998 (n = 1,999). MetS components included waist circumference, systolic blood pressure, fasting and 2-h postload plasma glucose, high-density lipoprotein (HDL) cholesterol, triglycerides, and homeostasis model assessment of insulin sensitivity (HOMA-S) (representing insulin sensitivity). Linear regression was used to determine which baseline components predicted deterioration in other MetS components over 5 years in AusDiab and 5 and 11 years in Mauritius, adjusted for age, sex, and ethnic group. Baseline waist circumference predicted deterioration (P < 0.01) in four of the other six MetS variables tested in AusDiab, five of six in Mauritius 1987-1992, and four of six in Mauritius 1987-1998. In contrast, an increase in waist circumference between baseline and follow-up was only predicted by insulin sensitivity (HOMA-S) at baseline, and only in one of the three cohorts. These results suggest that central obesity plays a central role in the development of the MetS and appears to precede the appearance of the other MetS components.
SEVENTY-EIGHT-WEEK DIETARY CARCINOGENICITY STUDY OF (±)-4-DIETHYLAMINO-1, 1-DIMETHYLBUT-2-YN-1-YL 2-CYCLOHEXYL-2-HYDROXY-2-PHENYLACETATE MONOHYDROCHLORIDE MONOHYDRATE (NS-21), A NOVEL DRUG FOR URINARY FREQUENCY AND INCONTINENCE, IN MICE (1997)

The oncogenic potential of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a new drug for the treatment of urinary frequency and incontinence, was assessed when it was administered in the diet of Charles River B6C3F1 mice for 78 weeks in dosages of 0, 30, 100 and 300 mg/kg/day. No drug-related effects occurred on survival, appearance or behavior, or occurrence, location or number of palpable masses. Average food consumption, food efficiency and hematologic values also were apparently unaffected. Statistically significantly low body weights were observed in the 100 and 300 mg/kg/day mice. The plasma concentrations of NS-21 and its active metabolite, RCC-36, in the treated groups were increased in a dose-dependent manner. Histopathological examinations disclosed midzonal hepatocellular vacuolization compatible with lipid vacuoles in both sexes at the 300 mg/kg/day dose level. There were no test article-related effects on the incidence or type of neoplastic lesions. In conclusion, under the conditions of this study, no oncogenic effects were evident in B6C3F1 mice when NS-21 was administered in the diet in concentrations to produce an intake of up to 300 mg/kg/day for 78 weeks.
Four-jointed Is a Golgi Kinase That Phosphorylates a Subset of Cadherin Domains (2008)

The atypical cadherin Fat acts as a receptor for a signaling pathway that regulates growth, gene expression, and planar cell polarity. Genetic studies in Drosophila identified the four-jointed gene as a regulator of Fat signaling. We show that four-jointed encodes a protein kinase that phosphorylates serine or threonine residues within extracellular cadherin domains of Fat and its transmembrane ligand, Dachsous. Four-jointed functions in the Golgi and is the first molecularly defined kinase that phosphorylates protein domains destined to be extracellular. An acidic sequence motif (Asp-Asn-Glu) within Four-jointed was essential for its kinase activity in vitro and for its biological activity in vivo. Our results indicate that Four-jointed regulates Fat signaling by phosphorylating cadherin domains of Fat and Dachsous as they transit through the Golgi.
Total Nitrogen Determination in Plant Material by Persulfate Digestion (1996)

Abstract Determination of total plant N concentration is important in understanding crop nutritional value, nutritional requirements, and physiological responses to the environment. Nitrogen analysis by either the Kjeldahl or Dumas method is expensive and requires specialized equipment. An alternative procedure, developed primarily for use on water samples, was optimized for digestion of vegetative soybean [ Glycine max (L.) Merr.] tissue and compared with the Dumas method. Finely ground plant material (0.425 mm) was digested in alkaline potassium persulfate (K 2 S 2 O 8 ) at 120°C (0.1 MPa) for 1.5 h in an autoclave, converting organic N to NO ‐ 3 . Nitrate in the digest was reduced to NO ‐ 2 and quantified by the sulfanilamide‐α‐naphthyl‐ethylenediamine dihydrochloride procedure. Persulfate digests of soybean material agreed closely with determinations made by the Dumas method ( r = 0.99). Digestion of NIST standard tomato ( Lycopersicon esculentum Mill.) leaves (4.8 g N 100 g −1 ) indicated complete N recovery (4.9 ± 0.1 g N 100 g −1 ). Persulfate digestion of total plant N was accurate and precise, and required little initial investment.
Using Lean principles to optimise inpatient phlebotomy services (2014)

This study illustrates how continuous process improvement through Lean can optimise workflow, improve timeliness, and decrease error in inpatient phlebotomy. We believe this manuscript adds to the field of clinical pathology as it can be used as a guide for other laboratories with similar goals of optimising workflow, improving timeliness, and decreasing error, providing examples of interventions and metrics that can be tailored to specific laboratories with particular services and resources.
Photon recycling semiconductor light emitting diode (2003)

A new white light emitting diode, the photon recycling semiconductor light emitting diode (PRS-LED) is demonstrated. The device consists of a GaInN/GaN LED emitting in the blue spectral range and an AlGaInP photon recycling semiconductor emitting at the complementary color. The PRS-LED thus has two emission lines, one in the blue and one in the amber wavelength range. The theoretical luminous efficiency of the PRS-LED exceeds 300 lm/W, higher than the efficiency of phosphor-based white LEDs.
Comment on Jackson et al. Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus. Diabetes Care 2017;40:723–725 (2017)

International audience
CA-MAC: Context Adaptive MAC Protocol for Wireless Sensor Networks (2009)

Energy efficiency is a critical issue for sensor network. In this paper we propose an energy efficient context adaptive MAC protocol for wireless sensor networks. The existing approaches improve energy efficiency by controlling the duty cycle of transmission period. The proposed protocol achieves that by letting each node stay in the sleep mode if the number of packets in the buffer is smaller than the threshold, while the threshold value is decided according to the distance of the node to the sink node. The variable threshold for each switch node, however, may cause increased latency. This problem is solved by immediately transmitting the packets of high priority context data. Computer simulation using OMNeT++ reveals that the proposed protocol significantly reduces the energy consumption compared with the existing S-MAC and T-MAC protocol.
The cell-stretcher: A novel device for the mechanical stimulation of cell populations (2016)

Mechanical stimulation appears to be a critical modulator for many aspects of biology, both of living tissue and cells. The cell-stretcher, a novel device for the mechanical uniaxial stimulation of populations of cells, is described. The system is based on a variable stroke cam-lever-tappet mechanism which allows the delivery of cyclic stimuli with frequencies of up to 10 Hz and deformation between 1% and 20%. The kinematics is presented and a simulation of the dynamics of the system is shown, in order to compute the contact forces in the mechanism. The cells, following cultivation and preparation, are plated on an ad hoc polydimethylsiloxane membrane which is then loaded on the clamps of the cell-stretcher via force-adjustable magnetic couplings. In order to show the viability of the experimentation and biocompatibility of the cell-stretcher, a set of two in vitro tests were performed. Human epithelial carcinoma cell line A431 and Adult Mouse Ventricular Fibroblasts (AMVFs) from a dual reporter mouse were subject to 0.5 Hz, 24 h cyclic stretching at 15% strain, and to 48 h stimulation at 0.5 Hz and 15% strain, respectively. Visual analysis was performed on A431, showing definite morphological changes in the form of cellular extroflections in the direction of stimulation compared to an unstimulated control. A cytometric analysis was performed on the AMVF population. Results show a post-stimulation live-dead ratio deviance of less than 6% compared to control, which proves that the environment created by the cell-stretcher is suitable for in vitro experimentation.
A new linear ion trap mass spectrometer (2002)

Abstract Characteristics of mass selective axial ion ejection from a linear quadrupole ion trap in the presence of an auxiliary quadrupole field are described. Ion ejection is shown to occur through coupling of radial and axial motion in the exit fringing fields of the linear ion trap. The coupling is efficient and can result in extraction of as much as 20% of the trapped ions. This, together with the very high trapping efficiencies, can yield high sensitivity mass spectral responses. The experimental apparatus is based on the ion path of a triple quadrupole mass spectrometer allowing either the q2 collision cell or the final mass analysis quadrupole to be used as the linear trap. Space charge induced distortions of the mass resolved features while using the pressurized q2 linear ion trap occur at approximately the same ion density as reported for conventional three‐dimensional ion traps. These distortions are, however, much reduced for the lower pressure linear trap possibly owing to the proposed axial ejection mechanism that leads to ion ejection only for ions of considerable radial amplitude. RF heating due to the high ejection q ‐value and the low collision frequency may also contribute. Two hybrid RF/DC quadrupole‐linear ion trap instruments are described that provide high sensitivity product ion scanning while operated in the linear ion trap mode while also retaining all conventional triple quadrupole scan modes such as precursor ion and neutral loss scan modes. Copyright © 2002 John Wiley &amp; Sons, Ltd.
Investigação do envolvimento do sistema serotonérgico no efeito hipotérmico de dois novos derivados n-fenilpiperazínicos (2004)

Estudos anteriores demonstraram que dois novos derivados N-fenilpiperaznicos (LASSBio579 e LASSBio581), planejados objetivando um novo prottipo de agente dopaminrgico, so agonistas D 2 pr-sinpticos e induzem um efeito hipotrmico em camundongos no mediado pela ativao direta de receptores D 1 e D 2 .Este efeito potencializado pela pr-administrao de altas doses de haloperidol, indicando uma potencial participao do sistema serotonrgico nesta ao.Este trabalho teve como objetivo avaliar o envolvimento do sistema serotonrgico no efeito hipotrmico de LASSBio579 e LASSBio581.Foram utilizados camundongos Swiss machos (20 a 30 g), provenientes da colnia da FEPPS.A temperatura retal dos animais foi determinada por termmetro digital.LASSBio579 e LASSBio581 foram administrados nas doses de 15, 30 e 60 mg/kg i.p. e o agonista 5-HT 2 ()-DOI na dose de 0, 5 mg/kg i.p.A pr-administrao de ()-DOI no alterou o efeito hipotrmico de LASSBio581 15 mg/kg; bloqueou parcialmente a hipotermia induzida por LASSBio581 30 mg/kg e completamente o efeito de LASSBio579 30 mg/kg e potencializou o efeito hipotrmico induzido pelas substncias na dose de 60mg/kg.Estes resultados so de difcil interpretao, mas demonstram a participao do sistema serotonrgico no efeito hipotrmico de LASSBio579 e LASSBio581.Visando esclarecer os dados obtidos, est em andamento a investigao do efeito dos novos derivados N-fenilpiperaznicos sobre comportamentos mediados pelo sistema erotonrgico.(Fapergs).
Massive Amounts of Tissue Factor Induce Fibrinogenolysis Without Tissue Hypoperfusion in Rats (2013)

Trauma-induced tissue factor (TF) release into the systemic circulation is considered to play an important role in the development of disseminated intravascular coagulation (DIC) immediately after severe trauma. However, the relationship between TF and hyperfibrinolysis, especially fibrinogenolysis, has been unclear. A total of 18 rats were divided into three groups: (a) the control group was infused with normal saline; (b) the low-dose group was infused with 4 U/kg TF; and (c) the high-dose group was infused with 16 U/kg TF. Arterial blood was drawn immediately and 2 and 4 h after the start of TF infusion. At each sampling point, arterial blood gases, platelet counts, and coagulation variables were measured. The fibrinogen degradation products were evaluated by a Western blot analysis. Hypotension, hypoxemia, and lactic acidosis were not observed in any of the three groups. In proportion to the doses of TF, the platelet counts, coagulation, and fibrinolysis variables deteriorated in line with DIC. The α2-plasmin inhibitor levels significantly decreased in the high-dose group compared with the other groups. The amounts of fibrinogen degradation products increased in proportion to the doses of TF. The plasmin-α2-plasmin inhibitor complex level in the high-dose group increased more than that of the other groups. In conclusion, TF can induce DIC associated with fibrinolysis and fibrinogenolysis without tissue hypoperfusion. The decrease in the α2-plasmin inhibitor level and the significant increase in the plasmin level may be the two main factors underlying the pathogenesis of hyperfibrin(ogen)olysis after TF administration.
A Fast Ferrite Switch for Use at 70 KMC (1958)

A normally open (attenuating) switch using ferrites has been built to operate in the 70-kmc region. It can be operated in 0.5 µsec and can be used with high duty cycles. The attenuation is about one db in the closed position and about 60 db in the open position. Construction and performance of the switch are discussed.
Biologic Skin Substitutes (1993)

There is no skin substitute that perfectly mimics autologous skin. However, recent developments show promise.
Display of native proteins onBacillus subtilisspores (2014)

In principle, protein display is enabled by fusing target proteins to naturally secreted, surface-anchored protein motifs. In this work, we developed a method of native protein display on the Bacillus spore surface that obviates the need to construct fusion proteins to display a motif. Spore coat proteins are expressed in the mother cell compartment and are subsequently assembled and deposited on the surface of spores. Therefore, target proteins overexpressed in the mother cell compartment during the late sporulation phase were expected to be targeted and displayed on the spore surface. As a proof of principle, we demonstrated the display of carboxymethylcellulase (CMCase) in its native form on the spore surface. The target protein, CMCase, was expressed under the control of the cry1Aa promoter, which is controlled by σ(E) and σ(K) and is expressed in the mother cell compartment. The correct display was confirmed using enzyme activity assays, flow cytometry, and immunogold electron microscopy. In addition, we demonstrated the display of a β-galactosidase tetramer and confirmed its correct display using enzyme activity assays and protein characterization. This native protein display system, combined with the robust nature of Bacillus spores, will broaden the range of displayable target proteins. Consequently, the applications of display technology will be expanded, including high-throughput screening, vaccines, biosensors, biocatalysis, bioremediation, and other innovative bioprocesses.
Dispersion monitoring and compensation using a single in-band subcarrier tone (2001)

We demonstrate a simple technique for dispersion monitoring by adding a single in-band tone to the data. Our technique has high accuracy and an easily reconfigurable measurement range. Dispersion compensation is also demonstrated using the monitor’s output.
Data-Driven Retrospective Cost Adaptive Control for Flight Control Application (2021)

Unlike fixed-gain robust control, which trades off performance with modeling uncertainty, direct adaptive control uses partial modeling information for online tuning. The present paper combines retrospective cost adaptive control (RCAC), a direct adaptive control technique for sampled-data systems, with online system identification based on recursive least squares (RLS) with variable-rate forgetting (VRF). The combination of RCAC and RLS-VRF constitutes data-driven RCAC (DDRCAC), where the online system identification is used to construct the target model, which defines the retrospective performance variable. This paper investigates the ability of RLS-VRF to provide the modeling information needed for the target model, especially nonminimum-phase (NMP) zeros. DDRCAC is applied to single-input, single-output (SISO) and multiple-input, multiple-output (MIMO) numerical examples with unknown NMP zeros, as well as several flight control problems, namely, unknown transition from minimum-phase to NMP lateral dynamics, flexible modes, flutter, and nonlinear planar missile dynamics.
Design of a 20 GHz Low Loss Ohmic Contact RF MEMS Switch (2007)

The design of a 20 GHz RF MEMS switch uses proven elements from previous designs operating from DC to 7 GHz. Extensive analysis of the RF performance of the original switch showed certain bandwidth limitations. Elimination of RF resonances, along with the addition of incremental ground vias and shortening of conducting stubs significantly improved performance. Prototypes of the modified switch have demonstrated outstanding RF performance from DC to more than 20 GHz. Typical performance shows less than 0.4 dB insertion loss, more than 20 dB return loss, and 25 dB isolation (@ 20 GHz).
Tailoring Nanoscale Phase Separation in New Gallogermanate and Gallosilicate Oxide Glasses: Application to Highly Transparent Glass-ceramics (2015)

International audience
Mechanical, thermal, and acoustical studies on natural alternative material for partition walls: A novel experimental investigation (2022)

Abstract The construction industry shows great interest in the use of technologically advanced materials which are light, environmentally friendly, possess high strength and durability for floors, roofs, partitions, etc. Apart from mechanical properties, the material should also possess excellent thermal and acoustic properties. In the same context, the aim of this study is to explore the flexural‐strength, thermal‐conductivity, flame resistance, and sound‐absorption capabilities of natural based material made with jute fiber and agglomerated cork. The natural based partition wall (jute board [JB]) was manufactured using vacuum bag molding process. Other alternative materials used in this study for comparison are gypsum and particle boards. A flexural test was carried out and it was observed that the JB has 80% of higher flexural strength than other test samples. It is also having lower thermal conductivity of 52.8% and 43.3% than gypsum and particle board, respectively. The JB have 35% and 10% higher sound absorption capabilities than gypsum and particle board, respectively. This is attributed to the multi‐scale arrangement and cellular structure of jute fiber and cork material. This study recommends that, if flame resistance of jute fiber is enhanced with help of flame retardants, JB that is, jute/cork sandwich panel could be an environmentally appealing alternative answer for use in the construction of partition walls.