gebhart/patrepeval huggingface dataset:
Blue-to-Red Chromatic Sensor Composed of Gold Nanoparticles Conjugated with Thermoresponsive Copolymer for Thiol Sensing (2007)

We describe the first determination of thiol compounds with gold nanocomposites composed of gold nanoparticles and thermoresponsive copolymers having polyamino groups. The gold nanocomposites, which are used as a chromatic sensor, reveal chromatic change from blue to red with thermal stimuli, heating followed by cooling the solution. The blue-to-red chromatic change results from disassembly of the gold nanocomposites, which arises from shrinkage of the thermoresponsive copolymers bound to the gold nanoparticle surfaces due to the phase transition induced by thermal stimuli. The disassembly is inhibited by addition of thiol compounds through displacement of the adhered thermoresponsive copolymers. The detached copolymers no longer influence morphological change of the gold nanocomposites. Corresponding with increase of concentration of the thiol compounds, a solution of the gold nanocomposites after the thermal stimuli shows chromatic change, which was quantified with the a* value in L*a*b* chromatic coordinates. A linear relationship between the a* value and concentration of cysteine, examined as a bio-important thiol, is obtained below 7x10(-6) mol dm(-3), estimating a detection limit defined as 3sigma of the blank to be 2.8x10(-7) mol dm(-3). The chromatic sensor of the gold nanocomposites is applied to the determination of cysteine in commercial supplements containing ascorbic acid, which seriously interferes with redox-based determination of cysteine. Analytical results obtained with the chromatic sensor are identical to those obtained with HPLC.
Rathke cleft cysts in pediatric patients: presentation, surgical management, and postoperative outcomes (2011)

The incidence of RCCs is much lower in the pediatric population; however, symptoms, imaging findings, and outcomes are similar, suggesting that pediatric RCCs arise from growth of remnants of the embryonic Rathke pouch earlier in life than adult RCCs but do not differ in any other way. It is important to consider RCCs in the differential diagnosis when pediatric patients present with visual impairment, unexplained headache, or hypopituitarism including growth delay. Although the average RCC size was similar in our pediatric and adult patient groups, the smaller size of the pituitary gland in pediatric patients suggests an increased relative RCC size.
A comparison of results from dynamic-response field tests (1988)

The dynamic response of Howden's 3 30-kW horizontal­ axis wind turbine ( HA WT) and the Northern Power Systems 100-kW North Wind HAWT has been measured. The How­ den machine incorporates a 26-m-diameter, upwind, three­ bladed, wood/epoxy rotor that operates at 42 rpm and is a rigid-hub design. The North Wind 100 rotor has a diameter of 17.8 m, is upwind, two-bladed, and constructed of fiberglass, and has a teetered hub. The Northern Power turbine's blades are fully pitchable, while the Howden machine uses pitchable blade tips. This paper will present the results from each of these test programs in an effort to compare the dynamic response of each turbine. The analysis will focus on rotor bending loads in terms of both time domain and frequency response. The FLAP code will be used to explore sensitivity to teeter stiffness and natural frequency placement to provide a better understanding of the differences in behavior caused by configuration alone. The results are presented in the form of normalized azimuth-averaged plots of the deterministic loads, and spectral density plots of the stochastic responses. This presentation of the results will contrast major response differences due to design configurations.
Cirrus and aerosol lidar profilometer - analysis and results (1996)

A cloud and aerosol lidar set from over a year of near continuous operation of a micro pulse lidar (MPL) instrument at the Cloud and Radiation Testbed (CART) site has been established. MPL instruments are to be included in the Ames Research Center (ARC) instrument compliments for the SW Pacific and Arctic ARM sites. Operational processing algorithms are in development for the data sets. The derived products are to be cloud presence and classification, base height, cirrus thickness, cirrus optical thickness, cirrus extinction profile, aerosol optical thickness and profile, and planetary boundary layer (PBL) height. A cloud presence and base height algorithm is in use, and a data set from the CART site is available. The scientific basis for the algorithm development of the higher level data products and plans for implementation are discussed.
Intramolecular Cyclization of Phenol Derivatives with C=C Double Bond in a Side Chain. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Medical Concept Embedding with Multiple Ontological Representations (2019)

Learning representations of medical concepts from the Electronic Health Records (EHR) has been shown effective for predictive analytics in healthcare. Incorporation of medical ontologies has also been explored to further enhance the accuracy and to ensure better alignment with the known medical knowledge. Most of the existing work assumes that medical concepts under the same ontological category should share similar representations, which however does not always hold. In particular, the categorizations in medical ontologies were established with various factors being considered. Medical concepts even under the same ontological category may not follow similar occurrence patterns in the EHR data, leading to contradicting objectives for the representation learning. In this paper, we propose a deep learning model called MMORE which alleviates this conflicting objective issue by allowing multiple representations to be inferred for each ontological category via an attention mechanism. We apply MMORE to diagnosis prediction and our experimental results show that the representations obtained by MMORE can achieve better predictive accuracy and result in clinically meaningful sub-categorization of the existing ontological categories.
Structural Applications of Reinforced Thermoplastics (2007)

Abstract During the last decade, the engineering community has increased the use of thermoplastic matrix composites due to their inherent advantages over traditional thermoset composites. Thermoplastic composites possess several advantages including: high toughness, low cost, short processing cycle times, recycling potential, excellent environmental and chemical resistance and high damage tolerance. Due to these advantages and to the increasing confidence and knowledge of designers and engineers on thermoplastic polymers a new range of applications are being developed for loading conditions and service environments where other materials just cannot perform in an efficient and cost effective manner. Thermoplastic matrix composites have a proven record of quality and success in several automotive applications such as in underbody panels (semi-structural), under the hood components for moderate to high temperature applications and corrosive environments. In this paper, a review of some of the most promising thermoplastic matrix composites for structural applications are presented including some innovative applications for mass transit developed at the University of Alabama at Birmingham (UAB) under a federal grant from the Department of Transportation (DOT).
PtRu/Carbon Nanotube Nanocomposite Synthesized in Supercritical Fluid:  A Novel Electrocatalyst for Direct Methanol Fuel Cells (2005)

Platinum/ruthenium nanoparticles were decorated on carbon nanotubes (CNT) in supercritical carbon dioxide, and the nanocomposites were characterized by transmission electron microscopy (TEM) and X-ray diffraction (XRD). TEM images show that the particles size is in the range of 5-10 nm, and XRD patterns show a face-centered cubic crystal structure. Methanol electrooxidation in 1 M sulfuric acid electrolyte containing 2 M methanol were studied onPtRu/CNT (Pt, 4.1 wt%; Ru, 2.3 wt%; molar ratio approximately Pt/Ru = 45:55) catalysts using cyclic voltammetry, linear sweep voltammetry, chronoamperometry, and electrochemical impedance spectroscopy. All the electrochemical results show that PtRu/CNT catalysts exhibit high activity for methanol oxidation which resulted from the high surface area of carbon nanotubes and the nanostructure of platinum/ruthenium particles. Compared with Pt/CNT, the onset potential is much lower and the ratio of forward anodic peak current to reverse anodic peak current is much higher for methanol oxidation, which indicates the higher catalytic activity of PtRu/CNT. The presence of Ru with Pt accelerates the rate of methanol oxidation. The results demonstrated the feasibility of processing bimetallic catalysts in supercritical carbon dioxide for fuel cell applications.
An adaptive feedback technique for disturbance rejection: Experimental results (1995)

The paper presents experimental results of a hybrid control technique that blends traditional fixed feedback control with adaptive feedback techniques. The objective is to provide damping for transient disturbances via the fixed part of the controller and rejection of steady disturbances via the adaptive part of the controller. This technique differs from the other hybrid techniques in that it does not require a measurement of an external signal coherent with the disturbance, nor does it require knowledge of how the disturbance enters the system. In addition, it provides damping to the system, unlike neutralization-loop techniques. As with all feedback techniques, stability is an issue. The adaptive controller is implemented in such a way as to minimize stability problems and in the case of perfect system identification it is guaranteed to be stable. The experimental results are from a cantilever beam with piezoceramic actuators and sensors. The results for the fixed feedback controller will be compared to those for the adaptive feedback control technique. The comparison will include results from harmonic, narrow-band, and broadband disturbances. [Work supported in part by ONR contract N00014-92-J-1170.]
Transactive control: A technique for widespread coordination of responsive Smart Grid assets (2012)

This presentation will summarize work on the Pacific Northwest Smart Grid Demonstration Project. A key element of the project is development and implementation of a technique referred to as transactive control. Transactive control will provide a means of coordinating the response of smart grid assets at all levels of the power system. In simple terms transactive control may be thought of as extending the notion of locational marginal pricing throughout the power system from generation to end-use. The transactional nature of the technique, however, introduces a new element in the use of a pair of signals to implement an equivalent to market closing distributed in space and time.
SUN-008 Loss of Antimullerian Hormone Immunoreactivity Due to a Homozygous AMH Gene Mutation Rs10417628 in a Woman with Classical Polycystic Ovary Syndrome (2020)

Abstract Anti-Müllerian hormone (AMH), an inhibitor of primordial/small antral follicle development and Leydig cell androgen synthesis in mice, could exaggerate the polycystic ovary syndrome (PCOS) phenotype, given reports of PCOS-specific AMH loss-of-function mutations (1–3). This report describes a normal-weight PCOS woman with severely reduced AMH levels (index PCOS woman). It examines the molecular basis for her reduced serum AMH levels and also compares her endocrine characteristics to similar-weight PCOS women with detectable AMH. Twenty normo-androgenic ovulatory (control) and 13 age- and body mass index-matched PCOS women (19–35 years; 19–25 kg/m2) underwent transvaginal sonography and serum hormone measures. Wilcoxon rank-sum test compared clinical features of control and PCOS women with detectable AMH, which were then individually ranked by magnitude in all PCOS women. DNA analysis was performed by PCR amplification with direct gene sequencing. The identified mutation was introduced in hAMH-expression plasmids for functional analysis of AMH processing in HEK293 cells by Western blot and ELISA (pico-AMH assay, Ansh Labs, Webster, TX), and for bioactivity in KK-1/AMHR2 cells using a luciferase reporter. Unpaired t-test compared AMH-induced luciferase activity between wild type and mutant AMH. A homozygous AMH gene mutation rs10417628 involving a single base pair substitution in exon 5 (NG_012190.1:g.7705C&amp;gt;T, p.(Ala515Val)) was identified in the index PCOS woman. PCOS women with detectable AMH had higher serum AMH (10.82 [6.74–13.40] ng/mL, Median [IQR]), total/free testosterone (T) (total T: 55.5 [49.5–62.5] ng/dL; fT: 5.65 [4.75–6.6] pg/mL) levels and greater total antral follicle numbers (AFNs) (46 [39–59] follicles) than controls (AMH: 4.03 [2.47–6.11] ng/ml; total T: 30 [24.5–34.5] ng/dL; fT: 2.2 [1.8–2.45] pg/mL; AFNs 16 [14.5–21.5] follicles, P&amp;lt;0.05, all values), along with a trend toward LH hypersecretion (P=0.06). The index PCOS woman with the lowest AMH levels (0.1 ng/ml) did not have the highest serum total T/fT (total T: 89 ng/dL; fT: 7 pg/mL,) or LH levels nor the greatest AFN (43 follicles). In vitro analysis of cells expressing hAMH-515Val or hAMH-515Ala showed that hAMH515-Val, in contrast to hAMH515-Ala, was undetectable and severely reduced in the pico-AMH assay in cell lysates and supernatants, respectively. AMH protein processing and AMH-induced luciferase activity, however, did not differ between hAMH515Val and hAMH515Ala. Thus, homozygous AMH mutation rs10417628 in a PCOS woman can impair serum AMH immunoreactivity without affecting AMH bioactivity, perhaps because of conformational changes from the mutation that only interfere with its immunodetection but not its function. References: 1. Teixeira J, et al. Endocrinology 1999;140:4732 2. Gorsic LK et al. JCEM 2019;104:2855 3. Broekmans FJ, et al. Trends Endocrinol Metab 2008;19:340
ChemInform Abstract: Phase Engineering of Transition Metal Dichalcogenides (2015)

Abstract Review: 101 refs.
Post marketing surveillance of captopril (for hypertension): a preliminary report. (1987)

1 The methodology and interim results of a post marketing surveillance of captopril, the first orally active angiotensin converting enzyme inhibitor are presented. 2 Utilising viewdata technology, details of hypertensive patients were entered directly into a mainframe computer. This allowed day to day monitoring of events; a facility not available with paper-based methods. 3 The design of the study allowed analysis of results including some details of efficacy, concomitant therapy, any disease symptoms and reasons for withdrawal. These factors could be categorised according to sex and age. 4 This preliminary report is based on the first 13,295 patients entered from July 1983 with follow-up until January 1985. The results of the study confirm the safety of captopril in the patients studied.
A Resource for Our Reagents: ACS Reagent Chemicals (2018)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTA Resource for Our Reagents: ACS Reagent ChemicalsJonathan V. SweedlerJonathan V. SweedlerMore by Jonathan V. Sweedlerhttp://orcid.org/0000-0003-3107-9922Cite this: Anal. Chem. 2018, 90, 9, 5511Publication Date (Web):April 23, 2018Publication History Published online23 April 2018Published inissue 1 May 2018https://pubs.acs.org/doi/10.1021/acs.analchem.8b01729https://doi.org/10.1021/acs.analchem.8b01729editorialACS PublicationsCopyright © 2018 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2142Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (226 KB) Get e-AlertscloseSUBJECTS:Quality management,Reagents Get e-Alerts
Prefilled Saline Breast Implants Offer Significant Advantages (1999)

Thomas M. Biggs, MD, Houston, TX , is a board-certified plastic surgeon and an ASAPS member.



Approximately 20 months ago, I started using prefilled saline breast implants as an alternative to conventional saline implants, which are filled at the time of surgery. I was interested in evaluating devices made by Poly Implants Prosthesis Corporation (Miami, FL) to see whether a prefilled saline breast implant offered a better result to patients seeking breast augmentation or reconstruction. The shell material is manufactured by a unique platinum-catalyst process that yields a thin yet durable device. …
Cytogenetics in Pediatric MDS - Data of the EWOG-MDS 98 Study. (2005)

Abstract Myelodysplastic syndrome (MDS) represents a heterogeneous group of hematopoietic stem cell disorders. Although the precise pathogenesis of MDS remains to be clarified, cytogenetic abnormalities appear to be involved in the disease mechanism and are considered an important factor in predicting clinical outcome. Here, we report the outcome of conventional cytogenetic analysis performed at diagnosis in 300 children with MDS who were enrolled in the prospective study EWOG-MDS 98. The patients were divided into 3 clinical groups: primary refractory cytopenia (RC) (n=142), primary advanced MDS (aMDS) (n=94), and MDS secondary to chemo- or radiation therapy, bone marrow failure disorders or familial disease (sMDS) (n=64). A full cytogenetic result was obtained in 263 cases (87.7%) including 116 (44.1%) with an abnormal clone. Comparing the 3 diagnostic subgroups, there was a statistically significant difference in the frequency of abnormalities observed. In RC, only 25 of 116 patients with successful analysis had a detectable clone that showed monosomy 7 as sole aberration in the majority of cases (52%). In addition, this subgroup also showed the greatest rate of failure to obtain a karyotypic result. In contrast, 42 (65.6%) of the sMDS cases were cytogenetically abnormal with a broad spectrum of aberrations including 16 patients (25%) with a complex karyotype (≥4 abr.). The presence of karyotypic evolution was also more frequently observed in this group. The overall karyotypic results showed monosomy 7 to be present in 50% of all abnormal cases, a figure that greatly exceeded the prevalence of the other frequent non-random aberrations of −5/del(5q), +8, del(7q), and +21, each of which occurred in 5–10% of abnormal cases. Despite the small numbers of these latter cases, clear trends of karyotypic events occurring in a particular clinical subgroup were demonstrated in the form of +8 with aMDS and −5/del(5q) with sMDS. The clinical and cytogenetic subgroups were further analyzed for correlations with gender and age. Whereas no clinical group showed any correlation between gender and karyotype, in RC and aMDS it was shown that patients with monosomy 7 were significantly younger than those with another karyotypic result (median 3.2 vs. 10.4 yrs and 5.2 vs. 11.0 yrs, respectively). The results demonstrate that while a general karyotypic picture can be defined in childhood MDS, future studies need to clearly differentiate between individual clinical subgroups.
Genetic and Immunological Markers of Insulin Dependent Diabetes in Black Americans (1995)

ICA and GAD65 autoantibody profiles and HLA-DR and DQ analysis were performed on 43 Black juvenile onset IDDM patients and 34 unrelated Black controls from Tennessee, USA. 75% of patients were positive for GAD65 autoantibodies but only 53% had ICA; 39% both ICA and GAD65 antibodies. The strongest HLA association was with the DR3 haplotype DRB1*03 DQA1*0501 DQB1*0201 (63% of patients v 12% of controls RR = 13.0, p < 0.00002). DRB1*04 DQA1*0301 DQB1*0302, associated with IDDM in Caucasians but rare in Negroids, occurred in 27% of patients and 6% of controls (RR = 5.9, p < 0.04). All patients carried DQB1*0302 or DQB1*0201. DQB1*0602 was significantly reduced in patients (2.4% v 41%, RR = 0.036, p < 0.008) and DRB1*1501 was absent in patients (0% v 35%). The frequency of GAD65 autoantibodies in Black American IDDM patients is comparable to that in Caucasians; however ICA positivity is reduced. GAD65 antibodies may therefore be a more sensitive serological test to identify individuals in the Black American general population for markers associated with increased risk of developing IDDM. Current screening methods for predicting preclinical IDDM in Caucasians relies on a combination of immune and HLA markers of IDDM; studies of these markers in the Black Americans will make it possible to extend these options to additional genetically diverse populations.
Ly‐49D Transfected NK Cells Show Reduced Interleukin‐10 Production in Response to H‐2d and Increased Lytic Activity: Implication by Interaction Using Class I MHC Alloantigen+ Target Cells in Pregnancy (2000)

After physiological stimulation with BALB/c or DBA/2 splenocytes, rat NK cells are able to synthesize IL-10. Recognition of mouse splenocyte major histocompatibility complex (MHC) by Ly49D mice receptor decreased IL-10 production. The observed increase in killing activity might be a result of this phenomenon. NK cell activation via the Ly49D receptor might play an important role in pregnancy failure, but cannot explain why CBA/J X DBA/2 matings are abortion prone, and CBA/J X BALB/c matings are abortion resistant.
Interplay between Efflux Pumps May Provide Either Additive or Multiplicative Effects on Drug Resistance (2000)

The effects of simultaneous expression of several efflux pumps on antibiotic resistance were investigated in Escherichia coli and Pseudomonas aeruginosa. Several combinations of efflux pumps have been studied: (i) simultaneous expression of a single-component efflux pump, which exports antibiotics into the periplasm, in combination with a multicomponent efflux pump that accomplishes efflux directly into the external medium; (ii) simultaneous expression of two single-component pumps; and (iii) simultaneous expression of two multicomponent pumps. It was found that when efflux pumps of different structural types were combined in the same cell (the first case), the observed antibiotic resistance was much higher than that conferred by each of the pumps expressed singly. Simultaneous expression of pairs of single-component or multicomponent efflux pumps (the second and third cases) did not produce strong increases in antibiotic resistance.