gebhart/patrepeval huggingface dataset:
Understanding the Behavior of Pthread Applications on Non-Uniform Cache Architectures (2011)

Future scalable multi-core chips are expected to implement a shared last-level cache (LLC) with banks distributed on chip, forcing a core to incur non-uniform access latencies to each bank. Consequently, high performance and energy efficiency depend on whether a thread's data is placed in local or nearby banks. Using compiler and programmer support, we aim to find an alternative solution to existing high-overhead designs. In this paper, we take existing parallel programs written in Pthreads, and show the performance gap between current static mapping schemes, costly migration schemes and idealized static and dynamic best-case scenarios.
Unbalanced M1/M2 Phenotype of Peripheral Blood Monocytes in Obese Diabetic Patients (2009)

The monocyte-macrophage system exists in at least two distinct phenotypes of differentiation: proinflammatory (M1) and anti-inflammatory (M2) (1,2). Macrophages, when infiltrated into obese adipose tissue, exhibit a phenotypic switch from M2 to M1 polarization, thereby contributing to obesity-induced adipose tissue inflammation and insulin resistance (1). Expression of both M1 and M2 markers is detected in circulating peripheral blood mononuclear cells as well as in atherosclerotic plaques (3). However, there have been no detailed studies on the M1/M2 phenotype of monocytes and their association with cardiovascular risks in obese subjects with type 2 diabetes. On the other hand, we demonstrated that pioglitazone, a thiazolidinedione class of insulin sensitizer, exerts an antiatherogenic effect independent of its antidiabetic effect …
Mobile robots at your fingertip: Bezier curve on-line trajectory generation for supervisory control (2004)

A new interfacing method is presented to control mobile robot(s) in a supervised manner. Mobile robots often provide global position information to an operator. This research describes a method whereby the operator controls a mobile robot(s) using his finger or stylus via a touchpad or touch screen interface. Using a mapping between the robot's operational site and the input device, a human user can provide routing information for the mobile robot. Two algorithms have been developed to create the robot trajectory from the operator's input. Information regarding numerous path points is generated when the operator moves his finger/stylus. To prune away meaningless point information, a simple but powerful significant points extracting algorithm is developed. The resulting significant points are used as waypoints. An on-line piecewise cubic Bezier curves (PCBC) trajectory generation algorithm is presented to create a smooth trajectory for these significant points. As the method is based on distance and not on time, the velocity of mobile robot can be controlled easily within its allowable dynamic range. The PCBC trajectory can also be modified on the fly. Simulation results are presented to verify these newly developed methods.
Distinct roles of the 7-transmembrane receptor protein Rta3 in regulating the asymmetric distribution of phosphatidylcholine across the plasma membrane and biofilm formation inCandida albicans (2017)

Fungal pathogens such as Candida albicans exhibit several survival mechanisms to evade attack by antifungals and colonise host tissues. Rta3, a member of the Rta1-like family of lipid-translocating exporters has a 7-transmembrane domain topology, similar to the G-protein-coupled receptors and is unique to the fungal kingdom. Our findings point towards a role for the plasma membrane localised Rta3 in providing tolerance to miltefosine, an analogue of alkylphosphocholine, by maintaining mitochondrial energetics. Concurrent with miltefosine susceptibility, the rta3Δ/Δ strain displays increased inward translocation (flip) of fluorophore-labelled phosphatidylcholine (PC) across the plasma membrane attributed to enhanced PC-specific flippase activity. We also assign a novel role to Rta3 in the Bcr1-regulated pathway for in vivo biofilm development. Transcriptome analysis reveals that Rta3 regulates expression of Bcr1 target genes involved in cell surface properties, adhesion, and hyphal growth. We show that rta3Δ/Δ mutant is biofilm-defective in a rat venous catheter model of infection and that BCR1 overexpression rescues this defect, indicating that Bcr1 functions downstream of Rta3 to mediate biofilm formation in C. albicans. The identification of this novel Rta3-dependent regulatory network that governs biofilm formation and PC asymmetry across the plasma membrane will provide important insights into C. albicans pathogenesis.
Development of A General Computation Agorithm for the Analysis ofMMIC Structures Based on A Three‐Dimensional Model (2002)

A generalized three‐dimensional computational numerical code is developed for Monolithic Microwave Integrated Circuit (MMIC) structures based on a full wave approach using integral equation techniques. The electromagnetic properties of the MMIC structures are calculated using a Method of Moments – Galerkin technique based on integral equations and the relevant Green function to obtain a rigorous formulation. The MMIC structures are assumed to have an arbitrary geometry involving orthogonal parallelepiped ‘cells’, each one of which is characterized with finite permittivity and conductivity values. A novel approach is proposed to treat the incident: reflected and transmitted waves at the two microstrip lines, which stand as input and output of the circuit. Their current distribution is also being taken into account in terms of incident, reflected and transferred waves. The derived matrix is being inverted and the obtained results are the unknown coefficients of the plane waves inside the ‘cells’ and also the reflection R and transfer T coefficients. The derived numerical results concern linear cases, while the examination of non‐linear structures have been taken into account in the analytical formulation.
OSEK/VDX network management (1998)

Future networked systems will provide system functionalities which are more comprehensive than the sum of the local functionalities of all nodes. Such functionalities require a lot of management tasks which are based on compatible behaviour of all nodes and network wide negotiations. In order to exempt the application from standard network management tasks and to avoid variant management and incompatibility problems the OSEK/VDX Network Management (NM) presents a standardized Application Programming Interface (API), behaviour and protocol.
Development of a Lower Energy Photosensitizer for Photocatalytic CO2 Reduction: Modification of Porphyrin Dye in Hybrid Catalyst System (2018)

A series of Zn–porphyrin dyes was prepared and anchored onto a TiO2 surface to complete a dye-sensitized photocatalyst system, Zn–porphyrin-|TiO2|-Cat, and tested as lower energy photosensitizers for photocatalytic CO2 reduction. Three major synthetic modifications were performed on the Zn–porphyrin dye to obtain a lower energy sensitization and improve the catalyst lifetime. We found that incorporating acetylene and linear hexyl groups into the Zn–porphyrin core allowed facile lower energy sensitization, and the addition of the cyanophosphonic acid as an anchoring group gave the long-term dye stability on the TiO2 surface. Under irradiation with red light of >550 nm and a light intensity of 207 mW/cm2, the hybrid ZnPCNPA catalyst showed a TONRe of ∼800 over an extended time period of 90 h. The photocatalytic activities of porphyrin hybrids differ greatly with the binding strength of the anchoring groups of dye and spectral range of the irradiated light and its intensity.
ROLE OF FRACTURE CLASSIFICATION SYSTEMS IN THE MANAGEMENT OF TIBIAL PILON FRACTURE COMPLEX (2010)

Introduction: Classification systems are useful in research and clinical practise as it provides a common mode of communication and evaluation. Tibial pilon injuries are a complex group of fractures, whose classification and radiological assessment in clinical practise remains undetermined.

Methods: 50 CT scans and radiographs of tibial pilon fractures were evaluated independently by 6 orthopaedic surgeons, comprising 3 consultants, 2 registrars and 1 research fellow. Fractures were classified according to ruedi allgower, AO, Topliss et al. Each surgeon was given a period of 48 hours to review copy of the original article as well as written and diagrammatic representations. Assessment was done on two occasions, 4 weeks apart. The kappa coefficient of agreement was calculated with SPSS to determine interobserver reliability and intraobserver reproducibility of the classification systems. The evaluator was blinded as to treatment and functional outcome. Each evaluator was also asked to decide upon the fracture management based on the classification types and was compared with the actual management.

Result: The interobserver agreement for ruedi allgower, Ao and Topliss et al., was fair, moderate and poor respectively. The intraobserver agreement for ruedi allgower, AO and Topliss et al., classifications was moderate at best. There was poor agreement amongst observers regarding definite management plan based on these classification systems.

Discussion: The interobserver agreement was directly proportional to the familiarity and inversely proportional to the specificity of the classification system. The intraobserver agreement improved with experience. CT scan helped in delineating the fracture segments accurately but did not significantly affect inter or intraob-server agreement.

Conclusion: Existing classification systems help in understanding the pathoanatomy of osseous part of tibial pilon fracture complex. However, Soft tissue injury forms an integral part of this complex. Without inclusion of soft tissue injury, these classification systems have limited role in definitive management.
Two Tracking Architectures Using Simple Adaptive Control Within a Linear Loop (2017)

The paper deals with control architectures when a Simple Adaptive Control (SAC) based subsystem is a part of a linear closed loop. The main issue of such control architecture is the stability. It is proved that a linear closed loop with a SAC based subsystem remains stable and the performance converges to a respective linear closed loop. Two cases with different control architectures are considered in the paper: (i) Three-loop missile autopilot with a SAC based fins actuator; (ii) A target tracking loop where the classical SAC architecture cannot be implemented per se and the model to be tracked is the target state estimator. The performance of these architectures is demonstrated by simulations.
Shear-strain-induced low symmetry phase and domain ordering in epitaxial La0.7Sr0.3MnO3 thin films (2008)

The domain structure in epitaxial La0.7Sr0.3MnO3 films grown on (LaAlO3)0.3(Sr2AlTaO6)0.7(001) substrates has been investigated by x-ray reciprocal space maps on (003), (103), (1¯03), (013), and (01¯3) reflections in the high-resolution scattering zone containing the c* axis, and the transmission electron microscopy. We revealed that at above 20nm, the films show clearly a low symmetry monoclinic phase, and the shear strain relaxation can induce a patterned domain structure and in-plane superlattice in the films. The domain width versus the film thickness and the shear strain effect on the Curie temperature of the films were also discussed.
Mettez de la couleur dans vos assiettes ! (2013)

Mettez de la couleur dans vos assiettes !. cycle de conférence Morlaix
Di-tert-butylisobutylsilyl, Another Useful Protecting Group (2011)

The di-tert-butylisobutylsilyl (BIBS) protecting group offers new possibilities for synthetic processes because of its steric bulk, robustness of its derivatives, and other special properties.
Association Between Respiratory Tract Methicillin-Resistant S<emph type="ital">taphylococcus aureus</emph> and Survival in Cystic Fibrosis (2010)

Detection of MRSA in the respiratory tract of CF patients was associated with worse survival.
Association Between Heart Rate Variability and Inflammatory Biomarkers in Critically Ill Children* (2022)

HRVi is inversely correlated with IL-6, IL-8, and CRP. Further studies are needed to validate this measure as a proxy for a proinflammatory state.
Simultaneous formation of haploid, diploid and triploid eggs in diploid–triploid mosaic loaches (2007)

In the loach Misgurnus anguillicaudatus , very few diploid–triploid mosaic individuals, which are generated by accidental incorporation of the sperm nucleus into diploid eggs produced by clonal diploid loach, occur in nature. Ploidy examination of gynogenetic progeny induced by activation with ultraviolet‐irradiated goldfish sperm indicated that diploid–triploid mosaic females laid haploid, diploid and triploid eggs, simultaneously. In addition, triploid eggs exhibited larger egg sizes. Microsatellite genotyping of diploid–triploid mosaics revealed that triploid genotypes of mosaic mothers possessed two alleles specific to the clonal diploid and one allele from normal diploid male. Diploid eggs from a mosaic mother had genotypes absolutely identical to the diploid clone. Most genotypes of triploid eggs were identical to the mosaic mother, and one of the three alleles of the mosaic mother was transmitted to haploid eggs. These results suggested that diploid germ cells, which had a clonal genome, were differentiated into clonal diploid eggs, and triploid and haploid eggs were produced from triploid germ cells in the same ovary of mosaic individuals.
Contribution of labeled carbon dioxide to PET imaging of carbon-11-labeled compounds. (1992)

11CO2 is one of the major metabolites of many [11C]-labeled radiopharmaceuticals, including glucose, thymidine, acetate, amino acids, and fatty acids. Our data contradict the notion that the contribution of labeled CO2 to PET images can be disregarded because of its rapid elimination through the lungs. We have measured the retention and excretion of 11CO2 in dogs after the intravenous injection of labeled CO2/HCO3-, which had been equilibrated ex vivo with blood. Only 58% of the label was exhaled as CO2 over the first 60 min after injection, with the rest retained in the body. The injection of [11C]thymidine labeled in the ring-2 position or [11C]acetate labeled in the carboxylate position resulted in the production of large amounts of labeled CO2 with the exhalation of about 47% and 23%, respectively, of the injected label over 60 min. At 10 min after injection of either [11C]thymidine and [11C] acetate, approximately 60% to 70% of total blood activity was in labeled CO2 or bicarbonate. On the other hand, the use of [1-11C]glucose only resulted in exhalation of 5% of the injected dose and CO2/HCO3- made up less than 10% of blood activity at 10 min. Our results indicate that retention and distribution of labeled CO2 needs to be considered when interpreting PET data obtained from 11C-labeled compounds.
SPECTROPHOTOMETRIC STUDY OF α‐ADRENOCEPTORS AFFECTING MICROCIRCULATION OF RAT SKIN (1993)

1. To determine the alpha-adrenergic receptor subtypes that affect the microcirculation of skin, the relative absorption (RA) spectra of the skin on the backs of rats were measured using reflectance spectrophotometric methods. We injected alpha-adrenergic agonists, noradrenaline (NA), phenylephrine (PE) and clonidine (CL), intravenously and determined changes in the RA value at 569 nm, one of the isosbestic points of the oxyhaemoglobin and deoxyhaemoglobin absorption. 2. NA reduced the RA value and the reduction was inhibited significantly by pretreatment with phenoxybenzamine (PBZ; P < 0.01). These findings suggested that the haemoglobin content in the skin tissue decreased as a result of vasoconstriction through alpha-adrenoceptors. 3. NA, PE and CL produced dose-dependent reductions in RA. CL and NA produced virtually equipotent reductions except at the highest dose used. PE produced smaller effects. The potency of these drugs in terms of changes in RA did not correlate with their potency in terms of rises in systemic blood pressure (NA > PE > or = CL). 4. Yohimbine (YO) inhibited the NA-induced reduction in RA to a greater degree than bunazosin (BU). Midaglizole, a specific alpha 2-adrenergic antagonist, significantly and dose dependently inhibited the NA-induced reduction in RA. 5. Although BU inhibited NA-induced reduction in RA only slightly, the effect was significant (P < 0.05). BU significantly inhibited PE-induced reduction (P < 0.01), but did not inhibit CL-induced reduction. 6. These observations suggest that the microcirculation of the skin of the rat is affected mainly by alpha 2-adrenoceptor mediated vasoconstriction. However, alpha 1-adrenoceptor mediated vasoconstriction also has some effect.
Method for providing adhesion to a metal surface (2023)

A process for treating metal surfaces to obtain improved susceptibility to bonding with adhesive compositions is disclosed. A metal surface is oxidized with a halogen to form a monolayer of halide ions on the surface. The halide ions are then exchanged with azide ions to form an azide monolayer on the metal surface. Upon contact of the treated surface with an adhesive composition, the azide layer may be thermally or photochemically decomposed to form active nitrene species, which react to bond the adhesive composition to the metal surface.
Review: Ocular side effects of anti-rheumatic medications: what a rheumatologist should know (2010)

Nearly every drug may cause changes to ocular tissues through a variety of mechanisms. Medication overdoses, drug-drug interactions but also chronic administration of medications at the recommended doses may lead to ocular toxicity. The ocular side effects, screening for eye toxicity and treatment guidelines for anti-inflammatory and immunosuppressive drugs commonly used by rheumatologists are reviewed herein.
TARGETING CHEMOKINE RECEPTORS CXCR3 AND CCR5 REDUCES RENAL ISCHEMIC INJURIES (2004)

P75 Aims: Through activation of the G-protein-coupled cell-surface receptor, chemokines have a pivotal role in the mobilization and activation of specific leukocyte subsets towards sites of inflammation. Chemokines have also emerged as key regulators in Th1/Th2 types of immune responses. These mechanisms have increasingly been recognized to be important in the pathogenesis of renal ischemic injuries (RII), hence forth, we sought to explore the role of chemokines in RII. Methods: Single kidney uninephrectomized model was used by performing a nephrectomy 3 days prior to induction of ischemia. The ischemia was induced by the application of a microvascular clamp to the renal pedicle for 40 minutes. We have performed a serial temporal intrarenal gene expression study (by Real-Time PCR) analyzing chemokine and chemokine receptor expression in this model at 45 minutes, day 1 and day3 post-clamping. Serum creatinine measurements and histology were also carried out at these time points. Results: Compared with the sham kidneys, the expression of CXCR3 ligand, IP-10 as well the expression of CCR5 ligands such as MIP-1 [wpgrcent]36[/wpgrcent] and RANTES was induced as early as 45 minutes and increased steadily over time. The expression of CCR5 and CXCR3 was also induced. There was no detectable expression of cytokines such as IL-4 and IFN-γ at these time points. To test the functionality of over expressed chemokine receptors CCR5 and CXCR3, we induced ischemia in the wild type (WT), CXCR3−/− and CCR5−/− mice. Although both CCR5−/− and CXCR3−/− mice had significantly lower levels of serum creatinine than the WT, the CXCR3 −/− mice had the lowest serum creatinine. Kidneys from CXCR3−/− also exhibited significantly less hyaline and granular casts in the distal portions of the nephron, and notably fewer nucleated inflammatory cells in the vasa recta. Conclusions: We conclude that CCR5 deficiency and in particular CXCR3 offeres a significant attenuation of renal ischemic injuries.Figure
Introduction to Human-Computer Interaction (HCI) Minitrack (2012)

Introduction to Human-Computer Interaction (HCI) Minitrack
Development of a microplate assay for serum chromogranin A (CgA): Establishment of normal reference values and detection of elevated CgA in malignant diseases (1999)

Chromogranin A (CgA), a marker for neuroendocrine cells, is associated with poor prognosis when detected by immunohistochemical technique in prostate tumors. We have developed an ELISA on microplates for serum CgA and established the normal reference range. We also attempted to find out whether elevated serum CgA levels could be found in patients with various malignant diseases. Because of non-Gaussian distribution, both medians and 97.5 percentiles of serum CgA levels for men and women of four different age groups were determined. For women, the median and 97.5 percentiles are 20.7 and 63.9 ng/mL for ages 20 to 50, and 32 and 93.8 for 50 to 80 years of age, respectively; for men, they are 27.9 and 78.4 ng/mL for ages 18 to 40 and 41.6 and 92 for 40 to 80 years old, respectively. Elevated serum concentrations of CgA were detectable in patients with prostate cancer not undergoing hormonal treatment, and in patients with various malignant diseases including nonendocrine carcinomas. Most elevated serum CgA levels were associated with sera containing highly elevated serum tumor markers. Drugs targeting neuroendocrine cells should be administered for cancer patients with elevated serum CgA levels.
Advances in Age-related Macular Degeneration Understanding and Therapy (2017)

While the development of anti-vascular endothelial growth factor (anti-VEGF) as a therapy for neovascular age-related macular degeneration (AMD) was a great success, the pathologic processes underlying dry AMD that eventually leads to photoreceptor dysfunction, death, and vision loss remain elusive to date, with a lack of effective therapies and increasing prevalence of the disease. There is an overwhelming need to improve the classification system of AMD, to increase our understanding of cell death mechanisms involved in both neovascular and non-neovascular AMD, and to develop better biomarkers and clinical endpoints to eventually be able to identify better therapeutic targets-especially early in the disease process. There is no doubt that it is a matter of time before progress will be made and better therapies will be developed for non-neovascular AMD.
Identification of Catabolite Repression as a Physiological Regulator of Biofilm Formation byBacillus subtilisby Use of DNA Microarrays (2003)

Biofilms are structured communities of cells that are encased in a self-produced polymeric matrix and are adherent to a surface. Many biofilms have a significant impact in medical and industrial settings. The model gram-positive bacterium Bacillus subtilis has recently been shown to form biofilms. To gain insight into the genes involved in biofilm formation by this bacterium, we used DNA microarrays representing >99% of the annotated B. subtilis open reading frames to follow the temporal changes in gene expression that occurred as cells transitioned from a planktonic to a biofilm state. We identified 519 genes that were differentially expressed at one or more time points as cells transitioned to a biofilm. Approximately 6% of the genes of B. subtilis were differentially expressed at a time when 98% of the cells in the population were in a biofilm. These genes were involved in motility, phage-related functions, and metabolism. By comparing the genes differentially expressed during biofilm formation with those identified in other genomewide transcriptional-profiling studies, we were able to identify several transcription factors whose activities appeared to be altered during the transition from a planktonic state to a biofilm. Two of these transcription factors were Spo0A and sigma-H, which had previously been shown to affect biofilm formation by B. subtilis. A third signal that appeared to be affecting gene expression during biofilm formation was glucose depletion. Through quantitative biofilm assays and confocal scanning laser microscopy, we observed that glucose inhibited biofilm formation through the catabolite control protein CcpA.