gebhart/patrepeval huggingface dataset:
Describing function-based analysis of a nonlinear hydraulic transmission line (1994)

This paper presents an analytical method of predicting and eliminating limit cycle conditions in hydraulic drive systems, where backlash in the actuator seal is the dominant nonlinearity. It is shown that limit cycle conditions are a strong function of certain plant parameters. The elimination of limit cycle conditions may thus be achieved by the alteration of certain inherent plant parameters. Fluid flow in a hydraulic pipe is modeled using transmission line theory. The sinusoidal-input describing function is used to indicate which values of the plant parameters would result in limit cycle conditions. The analytical results were verified on an experimental test bench.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome (2019)

Functional peptides encoded by short open reading frames are emerging as important mediators of fundamental biological processes. In this study, we identified a micropeptide produced from a putative long noncoding RNA (lncRNAs) that is important in controlling innate immunity. By studying lncRNAs in mice macrophages, we identified lncRNA 1810058I24Rik, which was downregulated in both human and murine myeloid cells exposed to LPS as well as other TLR ligands and inflammatory cytokines. Analysis of lncRNA 1810058I24Rik subcellular localization revealed that this transcript was localized in the cytosol, prompting us to evaluate its coding potential. In vitro translation with <sup>35</sup>S-labeled methionine resulted in translation of a 47 aa micropeptide. Microscopy and subcellular fractionation studies in macrophages demonstrated endogenous expression of this peptide on the mitochondrion. We thus named this gene mitochondrial micropeptide-47 (Mm47). Crispr-Cas9-mediated deletion of <i>Mm47</i>, as well as small interfering RNA studies in mice primary macrophages, showed that the transcriptional response downstream of TLR4 was intact in cells lacking Mm47. In contrast, <i>Mm47</i>-deficient or knockdown cells were compromised for Nlrp3 inflammasome responses. Activation of Nlrc4 or Aim2 inflammasomes were intact in cells lacking Mm47. This study therefore identifies, to our knowledge, a novel mitochondrial micropeptide Mm47 that is required for the activation of the Nlrp3 inflammasome. This work further highlights the functional activity of short open reading frame-encoded peptides and underscores their importance in innate immunity.
P1‐059: Hippocampal sclerosis (HpScl) in the elderly with dementia: Clinical, genetic and pathologic findings (2009)

HpScl is associated with hypoxic/ischemic damage to the hippocampus and with frontotemporal lobar degeneration with ubiquitin inclusions (FTLD-U), which are usually composed of TDP-43. We reviewed clinical and genetic features of HpScl, with respect to Alzheimer disease (AD) type pathology, in a consecutive autopsy series of 232 patients (127 men; average age 78 ± 10 years). HpScl was detected in 24 cases (10%), including 14 cases with minimal AD pathology (Braak NFT stage (BS) 3 or less and 10 cases with BS>3. All patients with BS 3 or less had FTLD-U, except one with pure HpScl. TDP-43 positive inclusions were detected in 96% of the cases. Eight of 14 with minimal Alzheimer pathology had onset of dementia after age 75, presenting with amnesia. Those with onset before age 75 tended to present with behavior or language difficulties. All 10 HpScl cases with BS>3 presented with amnesia often had other pathologic processes, including AD (9), Lewy body disease (3) or cerebrovascular disease (3). In non progranulin mutation carriers (n=18) we compared PGRN variant rs5848 alleles in the HpScl group to 467 controls and found that the T allele was more frequent with an odds ratio of 2.07 (95% CI from 1.06 to 4.05, p=0.030). In the 22 cases with apolipoprotein-E genotype, ϵ4 carrier frequency was greater in BS>3 than in BS 3 or less (p=0.03). In this autopsy series HpScl with minimal AD pathology (BS 3 or less) was detected in 6%. Another 4% had both HpScl and other pathologic processes. Those presenting after 75 with BS 3 or less are incorrectly diagnosed as AD because they present with amnesia. The T-allele of PGRN variant rs5848 was recently associated with decreased progranulin expression in the brain, presumably through altered micro RNA regulation. The association of this allele with HpScl and TDP-43 pathology suggests that decrease progranulin expression may play a pathogenetic role in late onset HpScl associated with FTLD-U in the elderly, and perhaps in cases of HpScl not associated with FTLD-U. The frequency of this process and it's misdiagnosis as AD has important implications for treatment and case-control genetic studies.
Optimal experiment design for quantum state tomography of a molecular vibrational mode (2008)

Optimal experiment design is used to collect a data set for the complete reconstruction of the vibrational quantum state of diatomic potassium molecules with maximum accuracy and a minimum number of experiments. The optimal configuration of experimental settings is obtained by minimizing the Cramér–Rao lower bound to the accuracy, which is attained in our reconstruction. The quantum state is reconstructed from the data set using maximum-likelihood estimation. Both optimal experiment design and maximum-likelihood estimation are solved efficiently as convex optimization problems.
Spectral Index of OAM-Carrying Ultrafast Localized Pulses (2020)

We investigate the spectral degree of freedom of OAM-carrying localized waves, and its influence on their transverse intensity distribution. In particular, we focus our attention on two different families of spectra, namely exponentially decaying spectra, which are very tightly connected to fundamental X-waves, and Bessel-modulated spectra. For each class we show how it is possible, by suitable manipulating their spectrum, to structure their transverse intensity distribution, thus creating a radial structure similar to that of Laguerre-Gaussian beams. To complete our analysis, we investigate the impact of the two spectral functions on linear and angular momentum of such localized waves.
Versorgungskonzept einer Charcot-Arthropathie der Lendenwirbelsäule bei spastischer Tetraparese nach WS-Trauma und deren Folgen (2021)

Die Inzidenz traumatischer Querschnittssyndrome in Deutschland erreicht 12:100.000 [1]. Mit dem Fortschritt der modernen operativen und rehabilitativen Therapiemöglichkeiten steigerte sich über die letzten Jahrzehnte sowohl die Lebenserwartung als auch die Mobilität. Somit häufen sich seltene Komplikationen und Spätfolgen wie die „Spinale Charcot Arthropathie“.
Abstract 3078: Effects of upamostat and opaganib on cholangiocarcinoma patient derived xenografts (2020)

Abstract Background: Upamostat is an orally available small molecule serine protease inhibitor that is a highly potent inhibitor of trypsin 1, trypsin 2 and trypsin 3 (PRSS1/2/3) as well as urokinase-type plasminogen activator (uPA) which are expressed in many cancers and mediate cell migration, invasion and tissue remodeling. Opaganib (ABC294640), a novel, orally available small molecule is a specific inhibitor of sphingosine kinase 2 (SPHK2), which phosphorylates sphingosine to sphingosine-1-phosphate (S-1-P). While proliferation induced by S-1-P is regulated by both sphingosine kinase 1 (SPHK1) and SPHK2, SPHK2 appears to be more involved in cancer. We aimed to investigate the potential antitumor effect of upamostat and opaganib, individually and in combination, on cholangiocarcinoma (CCA) patient derived xenografts (PDX) in nude mice. Methods: PAX165, a PDX from a surgically resected CCA, expresses substantial levels of SPHK2, PRSS1, PRSS2 and PRSS3. 4 groups of 18 mice were treated with either drug or both. Mouse weights and tumor volumes were measured. In addition, experiments were conducted using the chorioallantoic membrane (CAM) of chicken embryos. Results: Table 1 shows the average tumor size for the control, upamostat, opaganib, and upamostat+opaganib groups at the study end point (Day 42). Tumor volumes in the upamostat, opaganib, and upamostat+opagnib groups were significantly decreased compared to the control group. The CAM experiments are ongoing and will be presented at the AACR Annual Meeting. Change in tumor volumes (mean) of CCA PDX after opaganib, upamostat or combination treatmentControlOpaganibUpamostatOpaganib+UpamostatPre-treatment129.9128.7118.8126.8Day 42198.6102.093.3186.09Percent change Day 0-42+53%-21%-21%-32%P value vs. control0.00020.00100.0008 Conclusion: This preclinical study demonstrated that upamostat and opaganib resulted in tumor regression in mice. Body weights of the mice showed no significant inter- or intra- group differences. The combination of upamostat and opaganib treatment showed greater regression compared to either upamostat or opaganib alone. Studies are underway to identify the molecular mechanisms of their interaction. Citation Format: Faizal Z. Asumda, Mohamed A. Hassan, Yo Han Kim, Nellie A. Campbell, Xin Luo, Daniel R. O'Brien, Sarah A. Buhrow, Joel M. Reid, Michael J. Moore, Vered Katz Ben-Yair, Reza Fathi, Mark L. Levitt, Fabrice Lucien-Matteoni, Jennifer L. Leiting, Mark J. Truty, Lewis R. Roberts. Effects of upamostat and opaganib on cholangiocarcinoma patient derived xenografts [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 3078.
SHORT-TERM CALORIC RESTRICTION IN MICE PROMOTES RESOLUTION OF ATHEROSCLEROSIS, WHILE WEIGHT REGAIN ACCELERATES ITS PROGRESSION (2023)

ABSTRACT While weight loss is highly recommended for those with obesity, &gt;60% will regain their lost weight. This weight cycling is associated with elevated risk of cardiovascular disease, relative to never having lost weight. How weight loss/regain directly influence atherosclerotic inflammation is unknown. Thus, we studied short-term caloric restriction (stCR) in obese hypercholesterolemic mice, without confounding effects from changes in diet composition. Weight loss was found to promote atherosclerosis resolution independent of plasma cholesterol. From single-cell RNA-sequencing and subsequent mechanistic studies, this can be partly attributed to a unique subset of macrophages accumulating with stCR in epididymal adipose tissue (eWAT) and atherosclerotic plaques. These macrophages, distinguished by high expression of Fcgr4 , help to clear necrotic cores in atherosclerotic plaques. Conversely, weight regain (WR) following stCR accelerated atherosclerosis progression with disappearance of Fcgr4+ macrophages from eWAT and plaques. Furthermore, WR caused reprogramming of immune progenitors, sustaining hyper-inflammatory responsiveness. In summary, we have developed a model to investigate the inflammatory effects of weight cycling on atherosclerosis and the interplay between adipose tissue, bone marrow, and plaques. The findings suggest potential approaches to promote atherosclerotic plaque resolution in obesity and weight cycling through induction of Fcgr4+ macrophages and inhibition of immune progenitor reprogramming. Graphical abstract
Magnetic-Field Effects on a Compensated Cholesteric Liquid Crystal (1969)

By measuring changes in the dielectric constant of a 1.75:1 cholesteryl chloride–cholesteryl myristate (CM) mixture in the presence of magnetic fields H up to 10 kG, the orientation of the molecular and helical axes with respect to the field direction can be deduced, and the possibility of a dependence of the alignment process on the pitch Z of the helix is explored. When the sample thickness is much greater than Z, there is no preferred direction for the helix axis in the bulk, and applying H either ⊥ or ‖ to the sample causes the helix axis to align | H. This effect only occurs at Z &amp;gt; 10 μ, and only partial ordering occurs even at Tnematic. The angle δ between the long molecular axis of cholesteryl chloride and a plane ⊥ to the helix axis is reduced by application of H. Since δ is determined by the internal mechanical energy of the cholesteric structure, the decrease in δ becomes more pronounced as Z approaches infinity. A comparison is also made of the effects of electric and magnetic fields on CM; an electric field of 500 V/cm counteracts a magnetic field of the order of 10 kG. The anisotropy of the diamagnetic susceptibility is deduced to be ∼10−9.
Role of Mitochondria in the Phenotypic Expression of Feed Efficiency (2004)

Recent investigations were conducted on mitochondria obtained from broilers with low and high feed efficiency (FE) within the same genetic line that were fed the same diet, thereby allowing relationships between mitochondrial function and the phenotypic expression of FE to be clearly established. In these studies, breast muscle, liver and duodenal mitochondria obtained from broilers with high FE exhibited a more tightly coupled respiratory chain along with lower electron leak and reactive oxygen species (ROS) production compared with broilers with low FE. Elevated electron leak in low FE was due to site-specific defects in electron transport at Complex I, III, or both of the respiratory chains in breast and leg muscles and at Complex I, II, or III (depending on energy substrate) in duodenal mitochondria. Increased ROS production was presumably responsible for increased protein oxidation in low FE muscle mitochondria. Of 14 respiratory chain proteins investigated in breast muscle, the expression of 4 (3 in Complex III and 1 in Complex IV) was higher in low FE mitochondria. Interestingly, low FE was associated with a general suppression in respiratory chain complex activities (I, II, III, and IV) in breast muscle and liver. Elucidation of the mechanisms responsible for lower ROS production and tighter coupling of the respiratory chain in high FE mitochondria will greatly facilitate our understanding of the cellular basis for the phenotypic expression of FE.
Strength investigations on oil-board-arrangements in uniform electrical field (2004)

The oil-board insulation system is considered as competitionless standard insulation system in the high voltage technique for transformers, in particular to the high power range. The present knowledge status assumes, that for oil-board insulations always partial discharges occur, before breakdowns take place. In this paper it will be shown, that in uniform electrical field it is possible, that not always partial discharges can be measured before breakdown. Board has a specific resistance which is up to 100 times higher than that for oil. Charges can stick on the board surface and influence the electrical field and the electrical breakdown strength. Measuring this charging could be a new procedure for the non-destructive electrical strength limit recognition. This charging measuring technique is based on the fact, that board can be charged with an electrical field. The partial discharge measurement is a good method for failure recognition, but not always sensitive as indicator for the electrical strength recognition in oil-board insulation. In some cases the charging measurement method can be useful as method for determination of the electrical loading limit.
A Regular Nine-Prism Array of Patches for Wireless LANs (2007)

Since Smart Antenna technology has powerful spatial processing ability; it is regarded as a promising approach to enhancing the data rates and capacity of wireless LAN systems. In this paper, a small size, practical switched-beam antenna system, well suited for domestic in-home networking in the 2.4 GHz band, is designed and tested. The system has the configuration of regular nine-prism, and nine 1/4 wavelength rectangular patches are symmetrically distributed on the nine sides of the prism. The switching process is based on control of the microstrip used to feed the patch radiators, by placing PIN diodes at the microstrip feeding lines. The antenna array can generate nine beams with a gain of 11 dB. All the beams generated by the system are cophasal excited and have a 40° beamwidth. Compared to the uniform array, the system can guarantee the consistency of every beam and is preferable in shape.
Applicable apportion of commodity bills eased by wearable devices (2014)

With human civilization moving to cities and cities having housing societies with hundreds of residents, a common problem arises and that is to distribute the shared amenities and resource's usage bill among the residents of a housing society. Since the usage pattern of each residents is different (due to lifestyles and needs), so charging an average amount is not justified. In case where the usage of the resources is subscription based, all the subscribers of the amenity / resource should pay according to their usage. This paper discusses different methods to accurately calculate the bills for the residents (resource subscribers) for shared amenities and resources in a housing society. This paper also briefly discusses the importance of wearable devices in facilitating the authorization of the residents (resource subscribers) and collecting the resource usage information.
Insights from the energetics binding at the domain-ligand of the Src SH2 domain of water interface (2008)

SH2 domains play important roles in signal transduction by binding phosphorylated tyrosine residues on cell surface receptors. In an effort to understand the mechanism of ligand binding and more specifically the role of water, we have designed a general computational protocol based on the potential of mean force to compute the thermodynamics of water molecules at the protein-ligand interface for two SH2 domain complexes of the Src kinase, those bound to the two peptides Ac-PQpYEpYI-NH2 and Ac-PQpYIpYV-NH2 where pY indicates a phosphotyrosine. These two peptides were chosen because they have similar binding affinities but very different entropic/enthalpic thermodynamic binding signatures, indicating different interactions with solvent. We find that the isoleucine to valine mutation at position +3 (the third amino acid C-terminal to pY) in the ligand has only limited impact on the water structure. By contrast, the glutamic acid to isoleucine mutation at position +1 has a significant impact by not only abrogating a local hydrophilic binding site but, more importantly and surprisingly, inducing a favorable nonlocal entropic contribution from the water molecules around the phophorylated tyrosine at the +2 position. Our study demonstrates the validity of the method reported here for exploring the thermodynamic solvation landscape of protein-protein interactions. Proteins 2008. © 2008 Wiley-Liss, Inc.
The economic burden of brain metastasis among lung cancer patients in the United States (2016)

Development of brain metastasis among lung cancer patients is associated with a substantial economic burden to payers, patients, and employers.
Novel Drying Process Based on Self-Heat Recuperation Technology (2010)

Significant amounts of energy are used in the conventional methods for drying wet carbonaceous materials such as biomass, low-rank coals, sludge, and manure, because the latent heat for evaporating water is large. An innovative drying process, based on self-heat recuperation technology that recovers not only latent heat but also sensible heat, was developed to save drying energy. Water contained in a wet sample is heated to its boiling point, and the resulting steam is superheated. The superheated steam is compressed to provide a temperature difference for heat exchange. The condensation heat of the compressed steam is exchanged with the evaporation heat of the water from the wet sample. The sensible heat of the compressed steam is utilized to raise the temperature of both evaporated steam (superheating) and water contained in the wet sample (preheating). In addition, the sensible heat of the dried sample is recovered by gas to improve the overall energy efficiency. The amount of energy required for the proposed system was determined using a commercial process simulation tool, PRO/II (v. 8.1, Invensys plc, London, UK). The proposed drying process based on self-heat recuperation was found to drastically reduce the energy consumption to 13.7% of the energy consumption of the conventional drying process with heat recovery.
Monitoring G‐Quadruplex Structures and G‐Quadruplex—Ligand Complex Using 2‐Aminopurine Modified Oligonucleotides. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation of Labeled Casein fron Goat Milk after Lysine-14C Injection (1973)

Journal Article Preparation of Labeled Casein fron Goat Milk after Lysine-14C Injection Get access Fumiko Ehata, Fumiko Ehata Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo, Tokyo Laboratory of Food and Nutrition, Toita Women’s College, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Teru Ishibashi, Teru Ishibashi Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Masao Kametaka, Masao Kametaka Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Susumu Saito, Susumu Saito Laboratory of Food and Nutrition, Toita Women’s College, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Bumpei Mori Bumpei Mori Laboratory of Food and Nutrition, Toita Women’s College, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 37, Issue 8, 1 August 1973, Pages 1967–1969, https://doi.org/10.1080/00021369.1973.10860934 Published: 01 August 1973 Article history Received: 17 January 1973 Published: 01 August 1973
Fault Tolerant Spanners for General Graphs (2010)

This paper concerns graph spanners that are resistant to vertex or edge failures. In the failure-free setting, it is known how to efficiently construct a $(2k-1)$-spanner of size $O(n^{1+1/k})$, and this size-stretch trade-off is conjectured to be tight. The notion of fault tolerant spanners was introduced a decade ago in the geometric setting [C. Levcopoulos, G. Narasimhan, and M. Smid, in Proceedings of the 30th Annual ACM Symposium on Theory of Computing, 1998, pp. 186–195]. A subgraph H is an f-vertex fault tolerant k-spanner of the graph G if for any set $F\subseteq V$ of size at most f and any pair of vertices $u,v\in V\setminus F$, the distances in H satisfy $\delta_{H\setminus F}(u,v)\leq k\cdot\delta_{G\setminus F}(u,v)$. A fault tolerant geometric spanner with optimal maximum degree and total weight was presented in [A. Czumaj and H. Zhao, Discrete Comput. Geom., 32 (2004), pp. 207–230]. This paper also raised as an open problem the question of whether it is possible to obtain a fault tolerant spanner for an arbitrary undirected weighted graph. The current paper answers this question in the affirmative, presenting an f-vertex fault tolerant $(2k-1)$-spanner of size $O(f^{2}k^{f+1}\cdot n^{1+1/k}\log^{1-1/k}n)$. Interestingly, the stretch of the spanner remains unchanged, while the size of the spanner increases only by a factor that depends on the stretch k, on the number of potential faults f, and on logarithmic terms in n. In addition, we consider the simpler setting of f-edge fault tolerant spanners (defined analogously). We present an f-edge fault tolerant $(2k-1)$-spanner with edge set of size $O(f\cdot n^{1+1/k})$ (only f times larger than standard spanners). For both edge and vertex faults, our results are shown to hold when the given graph G is weighted.