gebhart/patrepeval huggingface dataset:
Corticotropin-releasing factor directly mediates colonic responses to stress (1987)

A new stress model in rats produced changes in intestinal function that resemble patterns of intestinal dysfunction associated with stress in humans: small intestinal transit was inhibited, large intestinal transit was stimulated, and fecal excretion was stimulated. To evaluate the role of corticotropin-releasing factor (CRF) in mediating the effects of stress on the intestine, we studied the actions of exogenous CRF on small and large intestinal transit in the rat and characterized the effects of pharmacological blockade of CRF receptors on stress-induced intestinal dysfunction. Administration of exogenous CRF (0.3-10.0 micrograms iv or icv) resulted in dose-related inhibition of gastric emptying, inhibition of small intestinal transit, stimulation of colonic transit, and stimulation of fecal excretion. The actions of exogenous CRF mimicked the effects of stress on the motor activity of the gastrointestinal tract. Administration of alpha-helical CRF-(9-41) (50 micrograms iv or icv), an antagonist of CRF, prevented the stress-induced increase in large intestinal transit and the associated increase in fecal excretion. These data suggest that endogenous CRF may mediate stress-induced changes in colonic function.
The Pytorch-kaldi Speech Recognition Toolkit (2019)

The availability of open-source software is playing a remarkable role in the popularization of speech recognition and deep learning. Kaldi, for instance, is nowadays an established framework used to develop state-of-the-art speech recognizers. PyTorch is used to build neural networks with the Python language and has recently spawn tremendous interest within the machine learning community thanks to its simplicity and flexibility. The PyTorch-Kaldi project aims to bridge the gap between these popular toolkits, trying to inherit the efficiency of Kaldi and the flexibility of PyTorch. PyTorch-Kaldi is not only a simple interface between these software, but it embeds several useful features for developing modern speech recognizers. For instance, the code is specifically designed to naturally plug-in user-defined acoustic models. As an alternative, users can exploit several pre-implemented neural networks that can be customized using intuitive configuration files. PyTorch-Kaldi supports multiple feature and label streams as well as combinations of neural networks, enabling the use of complex neural architectures. The toolkit is publicly-released along with a rich documentation and is designed to properly work locally or on HPC clusters. Experiments, that are conducted on several datasets and tasks, show that PyTorch-Kaldi can effectively be used to develop modern state-of-the-art speech recognizers.
ChemInform Abstract: Reactions of Rhodium(V) Hydrido‐Silyl Complexes with Butyl‐lithium and with Lithium Triethylhydridoborate. (1987)

Abstract Reaction of the dihydrido‐disilyl complexes (I) with LiBu leads to the anionic monohydrides (II) which regenerate the dihydrides (I) on treatment with MeOH.
Laryngeal Regulation of Airway Resistance I. Chemoreceptor Reflexes (1980)

The resistance of the larynx to airflow was measured during hypercapnia, hypoxemia, and stimulation of peripheral chemoreceptors by sodium cyanide and phenyl diguanide in 15 dogs anesthetized with alpha-chloralose (80 mg/kg). Laryngeal airway resistance (R1x) was obtained by measuring the pressure difference between the subglottic region and the mouth while a constant flow of humidified air was passed through the larynx. During spontaneous respiration, R1x varies with the phase of the respiratory cycle: R1x is high during expiration (mean +/- SEM = 0.79 +/- 0.19 cm H2O/L/sec) and falls just before inspiration (0.49 +/- 0.14 cm H2O/L/sec) and remains low until the end of inspiration. Hypercapnia, hypoxemia, and chemoreceptor stimulation each stimulated respiration and simultaneously decreased R1x during both inspiration and expiration. Chemoreceptor stimulation with phenyl diguanide (100 microgram/kg) and sodium cyanide (100 microgram/kg) produced similar decreases in R1x whether injected into the right atrium or left ventricle, indicating that these agents are not stimulating pulmonary receptors. The decrease in R1x during stimulation of chemoreceptors will decrease the work of ventilation. This study suggests that the control of ventilation involves the active regulation of the resistance of the laryngeal airway.
58-01: Stent-based isolation of pulmonary veins (2016)

Purpose: Atrial fibrillation is the most common arrhythmia in adults. Current therapies are hampered by high recurrence rates. We investigated a stent-based contactless energy transfer to isolate pulmonary veins in pigs. Methods: Nitinol self-expanding implants were positioned in the pulmonary veins of pigs. Using electromagnetic wireless energy transfer principles, implants were heated in a controlled fashion. Using an electrophysiological sensing and pacing catheter, signals were checked before and after the ablation, and conduction block persistence acutely and after one month were checked. Results: 11 animals were successfully treated. Implantation and wireless energy transfer were safely performed in all animals. While pacing with adequate conduction was successful in all animals prior to the ablation, conduction block was shown acutely in all eleven animals and chronically in seven animals. No periprocedural complications occurred, and the seven chronic animals remained in excellent shape until their sacrifice at one month. Histology confirmed the physical findings. The table shows the most relevant results (N°8-10 are acute sacrifices, 1–3 sacrificed at 1 month, 4–7 and 11 sacrificed at 3 months). Summary and Conclusions: We have –for the first time- proven that complete isolation of pulmonary veins using a contactless externally applied energy source to correctly positioned implants is safe and feasible, and that long-term isolation of pulmonary veins can thus be accomplished
Impact of Conditioning Intensity and Genomics on Relapse After Allogeneic Transplantation for Patients With Myelodysplastic Syndrome (2021)

This study provides evidence that targeted DNA sequencing in patients with MDS before transplant can identify those with highest post-transplant relapse rates. In those testing positive, random assignment to MAC lowered but did not eliminate relapse risk.
Electronic Lab Notebooks for Materials Synthesis (2023)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTElectronic Lab Notebooks for Materials SynthesisRaffaella Buonsanti*Raffaella BuonsantiLaboratory of Nanochemistry for Energy (LNCE), Institute of Chemical Sciences and Engineering (ISIC), École Polytechnique Fédérale de Lausanne, CH-1950 Sion, Switzerland*Email: [email protected]More by Raffaella Buonsantihttps://orcid.org/0000-0002-6592-1869Cite this: Chem. Mater. 2023, 35, 3, 805–806Publication Date (Web):February 14, 2023Publication History Received3 January 2023Published online14 February 2023Published inissue 14 February 2023https://pubs.acs.org/doi/10.1021/acs.chemmater.3c00019https://doi.org/10.1021/acs.chemmater.3c00019editorialACS PublicationsCopyright © 2023 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2901Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (859 KB) Get e-AlertscloseSUBJECTS:Chemical reactions,Chemical synthesis,Interfaces,Materials,Students Get e-Alerts
Evaluation of Egyptian bentonite and nano-bentonite as drilling mud (2013)

Nano-particles of bentonite have been prepared by nano-grinding. The nano-bentonite was characterized by X-ray fluorescence analysis (XRF), X-ray powder diffraction (XRD), thermal gravimetric analysis (TGA) and Transmission electron microscopy (TEM). The bentonite particles had been ground to the size ranging from 4 to 9 nm. Both natural and nano-bentonite were evaluated as drilling mud. The evaluation involved the study of the rheological properties, filtration and gel strength before and after treatment with viscosities and filter loss agent, and compared with the American Petroleum Institute API bentonite. With decreasing the grain size of bentonite to the nano-scale, the results were not satisfied to the API -standard.
Meat Industries: Characteristics and Manufacturing Processes (2012)

This chapter will give you an overview of the processes used and the products produced by the industries that we regulate. Each plant is unique, and the production processes used by plants have their own1.1 Introduction ...................................................................................................................................... 3 1.1.1 Denition of Terms.............................................................................................................. 51.2 Slaughter ........................................................................................................................................... 5 1.2.1 Beef Slaughter Process ........................................................................................................ 5 1.2.2 Pork Slaughter Process ........................................................................................................ 71.3 Raw Product: Not Ground ................................................................................................................ 8 1.3.1 Fabrication ........................................................................................................................... 9 1.3.2 Tenderization ..................................................................................................................... 10 1.3.3 By-Products ....................................................................................................................... 101.4 Mechanically Separated Product ....................................................................................................11 1.5 Raw Product: Ground ..................................................................................................................... 12 1.6 Irradiation ....................................................................................................................................... 15 1.7 Heat Treated but Not Fully Cooked: Not Shelf Stable ....................................................................16
Isolation and Identification of Camptothecin from Cells ofCamptotheca acuminataSuspension Cultures (1974)

Journal Article Isolation and Identification of Camptothecin from Cells of Camptotheca acuminata Suspension Cultures Get access Kuniaki Sakato, Kuniaki Sakato Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd., Machida, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Haruo Tanaka, Haruo Tanaka Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd., Machida, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Noboru Mukai, Noboru Mukai Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd., Machida, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Masanaru Misawa Masanaru Misawa Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., Ltd., Machida, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 38, Issue 1, 1 January 1974, Pages 217–218, https://doi.org/10.1080/00021369.1974.10861136 Published: 01 January 1974 Article history Received: 11 July 1973 Published: 01 January 1974
Spectinomycin modification. IV. The synthesis of 3'-aminomethyldihydrospectinomycins via spectinomycin 3'-cyanohydrins. (1988)

The C-3'-carbonyl group of N-protected spectinomycin is converted into the corresponding aminomethylalcohols via the intermediacy of cyanohydrins. Methodology for the selective synthesis of either epimer with retention of protection in the aminocyclitol ring provides valuable synthetic intermediates for the preparation of analogs of this important antibiotic. The new methodology provides an efficient synthesis of the highly active 3'-aminomethyldihydrospectinomycins.
U.S. Marine Corps Summer 1994 Mapping, Charting, and Geodesy Systems Requirements Evaluation. (1995)

Abstract : This report presents an analysis of the initial Marine Corps Requirements Analysis survey conducted by the Digital Mapping, Charting, and Geodesy (MC&G) Analysis Program (DMAP) staff during the Summer, 1994. The U.S. Marine Corps (USMC) initiated this effort with the Naval Research Laboratory (NRL) Digital Mapping, Charting, and Geodesy Analysis (MC&G) Program (DMAP) to provide a review of MC&G usage in key Marine Corps programs. This review should provide: (1) recommended improvements to Marine Corps usage of MC&G, (2) requirements to improve MC&O product reviews for Marine Corps, and (3) additional overview information for improved policy-making decisions on MC&G for the Marine Corps. (MM)
A parylene-based microelectrode array implant for spinal cord stimulation in rats (2011)

The design and fabrication of an epidural spinal cord implant using a parylene-based microelectrode array is presented. Rats with hindlimb paralysis from a complete spinal cord transection were implanted with the device and studied for up to eight weeks, where we have demonstrated recovery of hindlimb stepping functionality through pulsed stimulation. The microelectrode array allows for a high degree of freedom and specificity in selecting the site of stimulation compared to wire-based implants, and triggers varied biological responses that can lead to an increased understanding of the spinal cord and locomotion recovery for victims of spinal cord injury.
Plasma advanced oxidative protein products are associated with anti-oxidative stress pathway genes and malaria in a longitudinal cohort (2014)

Plasma AOPP levels were predictive for anaemia and oxidative stress markers for clinical malaria infection in two year old children. Several polymorphisms in GCLC, GSR and HMOX1 genes were associated with oxidative stress status of these children.
The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: Relationship to the structure of α-like DNA polymerases (1999)

Acyclovir (ACV), like many antiviral drugs, is a nucleoside analog. In vitro, ACV triphosphate inhibits herpesvirus DNA polymerase by means of binding, incorporation into primer/template, and dead-end complex formation in the presence of the next deoxynucleoside triphosphate. However, it is not known whether this mechanism operates in vivo. To address this and other questions, we analyzed eight mutant polymerases encoded by drug-resistant viruses, each altered in a region conserved among alpha-like DNA polymerases. We measured Km and kcat values for dGTP and ACV triphosphate incorporation and Ki values of ACV triphosphate for dGTP incorporation for each mutant. Certain mutants showed increased Km values for ACV triphosphate incorporation, suggesting a defect in inhibitor binding. Other mutants showed reduced kcat values for ACV triphosphate incorporation, suggesting a defect in incorporation of inhibitor into DNA, while the rest of the mutants exhibited both altered km and kcat values. In most cases, the fold increase in Ki of ACV triphosphate for dGTP incorporation relative to wild-type polymerase was similar to fold resistance conferred by the mutation in vivo; however, one mutation conferred a much greater increase in resistance than in Ki. The effects of mutations on enzyme kinetics could be explained by using a model of an alpha-like DNA polymerase active site bound to primer/template and inhibitor. The results have implications for mechanisms of action and resistance of antiviral nucleoside analogs in vivo, in particular for the importance of incorporation into DNA and for the functional roles of conserved regions of polymerases.
Indoor localization based on a single-tone SIMO-structured Doppler radar system (2018)

Indoor localization is a hot topic in microwave engineering. However, short-range localization of passive moving objects in indoor environments remains a technical challenge. In this paper, we propose a single-frequency continuous-wave Doppler radar sensor implemented in a form of a single-input multiple-output (SIMO) architecture with a redundant receiving channel. It only uses the Doppler information in the localization. In this case, this localization is naturally immune to stationary clutters such as walls and furniture, making it only responsive to moving objects. The obtained results imply the potential for the localization and tracking of moving objects in indoor environments with strong stationary scatters.
The Immunobiology of Receptor Activator for Nuclear Factor Kappa B Ligand and Myeloid‐Derived Suppressor Cell Activation in Immunoglobulin G4–Related Sclerosing Cholangitis (2018)

The primary function of myeloid-derived suppressor cells (MDSCs) is reflected in their immune modulatory role in several immune-mediated diseases. In immunoglobulin G4 (IgG4)-related disease (IgG4-RD), it has been hypothesized that there are selective regulatory defects that lead to a T helper 2 (Th2) bias immune response. Herein we have taken advantage of a large cohort of patients with IgG4-related sclerosing cholangitis (IgG4-SC), the most common extrapancreatic involvement of IgG4-RD, as well as controls consisting of primary sclerosing cholangitis, autoimmune hepatitis, and healthy volunteers, to study MDSCs. We report dramatically increased levels of receptor activator for nuclear factor kappa B ligand (RANKL) expression in serum and liver from patients with IgG4-SC compared to both liver-disease and healthy controls. Moreover, in IgG4-SC liver, RANKL-secreting cells specifically colocalized with cluster of differentiation 38-positive plasma cells and MDSCs, particularly monocytic MDSCs, and express the RANKL receptor in liver. Similarly, the frequency and number of peripheral blood MDSCs were significantly increased. Importantly, serum expression levels of RANKL were inversely correlated with the serum level of gamma-glutamyltransferase but significantly positively correlated with the frequency of MDSCs. Moreover, we confirmed that RANKL induced the expansion and activation of MDSCs through the RANKL/RANK/nuclear factor kappa B signal pathway. Of note, RANKL-treated MDSCs suppressed T-cell proliferation and induced Th2 differentiation. Conclusion: Our data suggest that plasma cell-derived RANKL induces the expansion and activation of MDSCs, which suppress T-cell proliferation and contribute to the Th2-type response characteristic of IgG4-SC.
Laboratory Investigations of Driven Low Frequency Plasma Oscillations (1973)

The work described in this report is directed toward exciting and identifying the parametric decay instability in an unmagnetized plasma. In the course of this work, we have found that low frequency oscillations can be excited by applying rf potentials in conjunction with dc potentials to grids immersed in the plasma, in addition to the well-known oscillations excited with dc potentials alone. Some of the low frequency oscillations that we have excited exhibit the characteristics of ion-acoustic waves associated with excitation of the parametric decay instability; however, the characteristics of all the oscillations reported in this work are similar and are thought to be the same phenomenon excited by different techniques. The report is divided into an experimental section followed by three sections that discuss the three general categories of low frequency oscillations that have been excited in an unmagnetized plasma.
Effect of Milk Concentration on Heat-Induced, pH-Dependent Dissociation of Casein from Micelles in Reconstituted Skim Milk at Temperatures between 20 and 120 °C (1998)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionEffect of Milk Concentration on Heat-Induced, pH-Dependent Dissociation of Casein from Micelles in Reconstituted Skim Milk at Temperatures between 20 and 120 °CSkelte G. AnemaCite this: J. Agric. Food Chem. 1998, 46, 8, 3402Publication Date (Web):July 18, 1998Publication History Published online18 July 1998Published inissue 17 August 1998https://pubs.acs.org/doi/10.1021/jf980710chttps://doi.org/10.1021/jf980710ccorrectionACS PublicationsCopyright © 1998 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views350Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (12 KB) Get e-Alertsclose Get e-Alerts
An Efficient Method of License Plate Location in Complex Scene (2010)

A novel license plate (LP) positioning algorithm is proposed in this paper. In this method, firstly, the input image is preprocessed. Then, the texture feature is used to remove most of disturbance. After that, the regions which have the structure and texture similar to the license plate are extracted. Finally, Pseudo-region is eliminated and true LP is precisely located. The working principle is taking full advantage of plate shape, texture characteristic and sharp-cut contrast to choose candidate areas, which simplify plate locating to a robust and efficient process.