gebhart/patrepeval huggingface dataset:
Development of an <i>In Vitro-In Vivo</i> Correlation for Sitagliptin and Metformin Prolonged-release Tablet Formulations (2020)

Correlation models can be useful for the prediction of FDCs during the management life cycle of the product. The models can also serve as a surrogate for <i>in vivo</i> studies. The FDC was tolerable, and the adverse events were mild and similar to those observed with the reference products. Therefore, the FDC is safe for use in human subjects.
Supplementary Table from Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155 (2023)

&lt;p&gt;Correlation of tumor androgen levels with SLC35F2 transcript expression in PDX models&lt;/p&gt;
Improved resolution of pulse superpositions in a knowledge-based system EMG decomposition (2005)

We have improved the accuracy (sensitivity x specificity) of a knowledge-based system from 90% to well above 95% in decomposing complex EMG 3-channel data into its constituent motor unit action potential (MUAP) trains. The key to achieving this improvement is our use of a probabilistic framework for resolving pulse superpositions through the application of utility maximization at the suprasegmental level.
ChemInform Abstract: Total Synthesis of (.+‐.)‐Scirpene. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Epstein Barr virus–positive B-cell lymphoma is highly vulnerable to MDM2 inhibitors in vivo (2021)

Epstein-Barr virus-positive (EBV-positive) B-cell lymphomas are common in immunocompromised patients and remain an unmet medical need. Here we report that MDM2 inhibitors (MDM2is) navtemadlin and idasanutlin have potent in vivo activity in EBV-positive B-cell lymphoma established in immunocompromised mice. Tumor regression was observed in all 5 EBV-positive xenograft-associated B-cell lymphomas treated with navtemadlin or idasanutlin. Molecular characterization showed that treatment with MDM2is resulted in activation of p53 pathways and downregulation of cell cycle effectors in human lymphoma cell lines that were either EBV-positive or had undetectable expression of BCL6, a transcriptional inhibitor of the TP53 gene. Moreover, treatment with navtemadlin resulted in tumor regression and prevented systemic dissemination of EBV-positive lymphoma derived from 2 juvenile patients with posttransplant lymphoproliferative diseases, including 1 whose tumor was resistant to virus-specific T-cell therapy. These results provide proof-of-concept for targeted therapy of EBV-positive lymphoma with MDM2is and the feasibility of using EBV infection or loss of BCL6 expression to identify responders to MDM2is.
Using note-taking appliances for student to student collaboration (2003)

Student collaboration is important in courses that utilize project-based learning. The authors describe how they tried to enhance this collaboration by testing electronic note-taking appliances along with the NotePals system. NotePals is a note-sharing system that captures and provides access to handwritten notes and documents of interest to a workgroup. Notes can be shared with other group members by synchronizing with a shared note repository that can be viewed using desktop-based web browsers. Students will only be able to take advantage of shared notes when note taking devices are inexpensive and pervasive. Consequently, the authors have developed note-taking applications that run on inexpensive personal digital assistants (PDAs) and other ink-based capture devices. This paper gives an overview of the NotePals system and describes the early usage of the system for note taking by students.
Prediction of Hysteresis Performance of Storage Reservoirs (1998)

Abstract Based on equations describing pressure-content performance of gas reservoirs subject to water drive, the paper presents a solution developed for prediction of hysteresis performance of storage fields. The method validated using field data form several storage reservoirs has been developed into a storage performance simulator with a number of applications of interest to the storage industry. Prognostic reservoir studies for detecting loss of storage gas due to migration or wellbore seepage, calculation of cumulative loss as a function of time, cycling of aquifers, and recoverability of cushion gas are among the applications presented. P. 247
Alien Vision: Exploring the Electromagnetic Spectrum with Imaging Technology (2001)

Austin Richards takes readers on a visual tour of the electromagnetic spectrum beyond the range of human sight, using imaging technology as the means to 'see' invisible light. Dozens of colorful images and clear, concise descriptions make this an intriguing, accessible technical book. Richards explains the light spectrum, including visible light, and describes the advanced imaging technologies that enable humans to synthesize our own version of 'alien' vision at different wavelengths, with applications ranging from fire fighting and law enforcement to botany and medicine
Isothermal Martensitic Transformations in an Aged Ni-Rich Ti–Ni Alloy Containing Coherent Ti<sub>3</sub>Ni<sub>4</sub> Particles (2019)

The time dependence nature of B2 (ordered cubic) to R (trigonal) and R to B19′ (monoclinic) martensitic transformations in an aged Ni-rich Ti–Ni alloy was investigated by electrical resistivity measurements. Both B2 to R and R to B19′ transformations exhibit time dependence nature in the aged alloy containing coherent lenticular Ti3Ni4 precipitates with an average diameter of about 110 nm. However, the successive B2-R-B19′ isothermal transformation is not detected by electrical resistivity measurements. The isothermal R-B19′ transformation is visualized by in situ scanning electron microscopy (SEM) observations.
Panel of aneuploid cell lines for physical mapping of the proximal long arm of human chromosome 21 (2005)

Some forms of familial Alzheimer disease (FAD) have shown linkage to DNA probes for the loci D21S1 and D21S16 on chromosome 21. To investigate the physical location of these DNA probes, we have constructed a physical map of this region of chromosome 21 by using quantitative Southern blot analysis of DNA sequences unique to chromosome 21 and a series of cell lines aneuploid for parts of chromosome 21. We now show that both D21S16 and D21S1/S11 are located in the same region of chromosome 21, in q11.2-q21.05. This new panel of aneuploid cell lines will allow the rapid mapping of new DNA probes in the vicinity of the FAD gene.
Abstract LB-193: Separable bilayer microfiltration device for viable label-free enrichment of circulating tumor cells (2014)

Abstract We designed a new separable bilayer (SB) microfiltration device for the viable enrichment of circulating tumor cells (CTCs) independent of antigen expression. Bilayer pore structures at the micro scale decrease cell damage to preserve viability, while maintaining throughput to allow rapid enrichment. The large pore size (40 um) of the upper layer facilitates the CTCs proliferation on chip. The separability enables the efficient release of the CTCs after successful on chip culture of captured CTCs. We characterized the device performances including capture efficiency, enrichment against leukocytes, viability and proliferability. The SB device can enrich tumor cells with 80% capture efficiency, higher than 103 enrichment, and better than 70% viability from 1 mL whole blood samples on a 1 cm2 device. Multiple cell lines were shown to be able to proliferate after captured on SB device. Furthermore, using CTCs derived from an in vivo model system, cell cultures were established by releasing the captured CTCs from the chip. The cultured CTCs and their corresponding parental cell lines were injected into mice. Tumors were established with no discernable differences in volume and rate of growth, demonstrating similar tumorigenicity of viable CTCs recovered by the SB device. In a feasibility study, we successfully detected CTCs from 1 mL of clinical whole blood sample enriched via SB device. Citation Format: Ming-Da Zhou, Sijie Hao, Anthony J. Williams, Bo Lv, Jiyue Zhu, Richard J. Cote, Ram H. Datar, Yu-Chong Tai, Siyang Zheng. Separable bilayer microfiltration device for viable label-free enrichment of circulating tumor cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-193. doi:10.1158/1538-7445.AM2014-LB-193
A framework for ranking of WSNs performance based on cloud model and entropy weight (2014)

Wireless Sensor Network (WSN) has become one of the cutting edge technologies, more attention has been paid to the further development and more applications emerging, WSNs is no longer confined to the traditional area. Due to the characters of dynamic, distribution, resource constrained, uncertainty, complexity and heterogeneity, we need a whole evaluation framework of WSNs performance, which can allow users choose and monitor the operation state. In this paper, we construct WSNPI architecture to rank and observe WSNs, which includes WSNPI Broker, Monitoring and WSNs Catalogue. We offer a more comprehensive evaluation index system including accountability, agility, cost, security and privacy, then build a cloud model and entropy weight method to evaluate WSNs performance. Finally, the proposed method has been serviced to complex simulation, and the results have indicated that the model is objective and effective. The first part is the research status and related problems. The second part is the establishment of an evaluation framework and model. The last part is the numerical example analysis and conclusion.
Dissection of the Posterior Hyaloid (1998)

Vitreoretinal surgery increasingly implies elimination of the posterior hyaloid. Many different surgical techniques have been described. The aspiration of the posterior hyaloid with a flexible silicone cannula and posterior separation with an illuminated spatula is the most frequently used. We herein describe a slight variation of this technique that makes the dissection of the posterior hyaloid easier in cases in which it has a strong attachment to the retina. We have used this technique on 12 patients (7 with choroidal neovascularization and 5 with idiopathic macular hole [1 patient with stage 2 and 4 patients with stage 3]) with strong attachment of the posterior hyaloid to the retina, immediately obtaining in all cases the separation of both structures without complications.
Assessment of knowledge and attitudes regarding automated external defibrillators and cardiopulmonary resuscitation among American University students (2012)

This study found that most students at an American university can identify CPR and AEDs, but do not understand their basic mechanisms of action or are willing to perform CPR or use AEDs unassisted. Recent CPR/AED training and 9-1-1 assistance increases comfort. The most common fear reported was incorrect CPR or AED use. Almost all students could not recall where an AED was located in a student centre.
Streamlining inter-operation memory communication via data dependence prediction (1997)

We revisit memory hierarchy design viewing memory as an inter-operation communication agent. This perspective leads to the development of novel methods of performing inter-operation memory communication. We use data dependence prediction to identify and link dependent loads and stores so that they can communicate speculatively without incurring the overhead of address calculation, disambiguation and data cache access. We also use data dependence prediction to convert, DEF-store-load-USE chains within the instruction window into DEF-USE chains prior to address calculation and disambiguation. We use true and output data dependence status prediction to introduce and manage a small storage structure called the transient value cache (TVC). The TVC captures memory values that are short-lived. It also captures recently stored values that are likely to be accessed soon. Accesses that are serviced by the TVC do not have to be serviced by other parts of the memory hierarchy, e.g., the data cache. The first two techniques are aimed at reducing the effective communication latency whereas the last technique is aimed at reducing data cache bandwidth requirements. Experimental analysis of the proposed techniques shows that: the proposed speculative communication methods correctly handle a large fraction of memory dependences; and a large number of the loads and stores do not have to ever reach the data cache when the TVC is in place.
The SNAC1-targeted gene OsSRO1c modulates stomatal closure and oxidative stress tolerance by regulating hydrogen peroxide in rice (2012)

Abiotic stresses such as drought cause a reduction of plant growth and loss of crop yield. Stomatal aperture controls CO(2) uptake and water loss to the atmosphere, thus playing important roles in both the yield gain and drought tolerance of crops. Here, a rice homologue of SRO (similar to RCD one), termed OsSRO1c, was identified as a direct target gene of SNAC1 (stress-responsive NAC 1) involved in the regulation of stomatal aperture and oxidative response. SNAC1 could bind to the promoter of OsSRO1c and activate the expression of OsSRO1c. OsSRO1c was induced in guard cells by drought stress. The loss-of-function mutant of OsSRO1c showed increased stomatal aperture and sensitivity to drought, and faster water loss compared with the wild-type plant, whereas OsSRO1c overexpression led to decreased stomatal aperture and reduced water loss. Interestingly, OsSRO1c-overexpressing rice showed increased sensitivity to oxidative stress. Expression of DST, a reported zinc finger gene negatively regulating H(2)O(2)-induced stomatal closure, and the activity of H(2)O(2)-scavenging related enzymes were significantly suppressed, and H(2)O(2) in guard cells was accumulated in the overexpression lines. OsSRO1c interacted with various stress-related regulatory and functional proteins, and some of the OsSRO1c-interacting proteins are predicted to be involved in the control of stomatal aperture and oxidative stress tolerance. The results suggest that OsSRO1c has dual roles in drought and oxidative stress tolerance of rice by promoting stomatal closure and H(2)O(2) accumulation through a novel pathway involving regulators SNAC1 and DST.
ChemInform Abstract: SYNTHESES OF HETEROCYCLIC COMPOUNDS. DCXXVI. MODIFIED SYNTHESIS OF PENTAZOCINE (1976)

Abstract Zur Herstellung von Pentazocin (VII) wird Tyrosin (I) verestert, N‐benzyliert und mit Bernsteinsäureesterchlorid acyliert.
Creativity at work (2016)

ESSSuper CEO Mark Puli's pursuit of innovation is inspired by his lifelong passion for continual learning, resulting in mighty success for the fund and its members. Alecia Pinner reports.
Transient dynamics of stimulated Brillouin scattering in optical communication systems (1992)

Dynamic aspects of stimulated Brillouin scattering (SBS) and criteria for its occurrence in optical communications are studied numerically. SBS is shown to cause sharp amplitude modulations in phase-shift keying (PSK) modulated systems close to or above the SBS threshold. It is shown that the convolution method to high accuracy yields correct relative gains for different modulation sequences. The transient change of backscattered radiation caused by abrupt changes in the modulation format is studied and it is demonstrated that the transition can occur on different time scales.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
LPE Growth Techniques for Fabricating Abrupt Zinc‐ and Magnesium‐Doped p+‐n InGaAsP / InP Heterojunctions (1982)

Utilizing a new method for introducing dopants into liquid phase epitaxy melts, abrupt Zn‐ and Mg‐doped heterojunctions have been produced. The junctions have been characterized electrically by C‐V and I‐V measurements and chemically by scanning Auger microscope (SAM) and secondary ion mass spectroscopy (SIMS). The C‐V measurements, extended to forward bias region, indicate an abrupt junction with a built‐in potential of 1V for p+‐n diodes (p+:1018 cm−3, ). Auger analyses show that the transition width between and is less than 10 nm, while SIMS profiling of Zn‐ and Mg‐doped p+‐n heterojunctions indicates that the Zn and Mg concentrations fall by more than two orders of magnitude within 150 and 50 nm of the interface, respectively.
High-Throughput Methods for Screening Polymeric Transfection Reagents (2013)

The clinical success of gene therapy requires the development of a safe and efficient delivery system for DNA. Cationic polymers are nonviral vectors that can associate electrostatically with plasmid DNA to form nanocomplexes. In some cases, this is sufficient for cellular uptake and transfection, although the precise mechanisms by which polymers facilitate gene delivery remain unclear. A robust and reliable method to screen for efficacy is essential for the development of effective polycationic transfection reagents. Numerous parameters must be controlled and optimized, such as polymer structure, polymer-DNA-binding conditions (mixing method, pH, ionic strength, incubation time, concentrations, ratios), transfection media (type, serum content), DNA dose and incubation time with the cells, cell specificity, and assay conditions. In this protocol, we describe a high-throughput method for assessing polymer-mediated transfection. The technique uses 96-well plates, which allows many transfection parameters to be varied and optimized in parallel. Hundreds of polymers can be tested in quadruplicate in a single day and the technique can easily be automated to efficiently and reproducibly test large material libraries. One limitation is that many plate types, solutions, and equipment must be stocked and sterilized. Moreover, because all polymers are processed simultaneously in very small volumes, it is difficult to validate each step for each polymer to ensure solution uniformity and adequate polymer-DNA complexation. Despite these drawbacks, this high-throughput screening method has already been used successfully in the development of efficient polycation vectors.
Impact of tool design on defect detection sensitivity for EUV actinic blank inspection (2017)

In this paper, we discuss the impact of various tool design perspectives on defect detection sensitivity for dark-field based EUV actinic blank inspection. We consider the impact from optical resolution (pixel size), EUV source type, and photon collection efficiency on critical defect SNR performance. The results show that as the pixel size approaches the target defect image size, defect SNR increases, and that pixel size also determines the dominant noise source in the inspection system. Moreover, the choice of the EUV source affects the optimal NA and illumination settings. For plasma-discharged sources, more photons provided by larger partial coherent illumination can improve the defect SNR, while coherent illumination is needed to get a higher defect SNR for synchrotron-based source. In the end, we show that simply increasing the photon collection efficiency by using high NA optics or increasing the source power cannot always improve the defect SNR. In a speckle noise dominated situation, larger outer NA includes more noise than defect signal, thus results in a lower SNR. The impact of source power also saturates at certain level as the system becomes speckle noise limited compared to photon noise limited.
Geometric compression through topological surgery (1998)

The abundance and importance of complex 3-D data bases in major industry segments, the affordability of interactive 3-D rendering for office and consumer use, and the exploitation of the Internet to distribute and share 3-D data have intensified the need for an effective 3-D geometric compression technique that would significantly reduce the time required to transmit 3-D models over digital communication channels, and the amount of memory or disk space required to store the models. Because the prevalent representation of 3-D models for graphics purposes is polyhedral and because polyhedral models are in general triangulated for rendering, this article introduces a new compressed representation for complex triangulated models and simple, yet efficient, compression and decompression algorithms. In this scheme, vertex positions are quantized within the desired accuracy, a vertex spanning tree is used to predict the position of each vertex from 2,3, or 4 of its ancestors in the tree, and the correction vectors are entropy encoded. Properties, such as normals, colors, and texture coordinates, are compressed in a similar manner. The connectivity is encoded with no loss of information to an average of less than two bits per triangle. The vertex spanning tree and a small set of jump edges are used to split the model into a simple polygon. A triangle spanning tree and a sequence of marching bits are used to encode the triangulation of the polygon. Our approach improves on Michael Deering's pioneering results by exploiting the geometric coherence of several ancestors in the vertex spanning tree, preserving the connectivity with no loss of information, avoiding vertex repetitions, and using about three fewer bits for the connectivity. However, since decompression requires random access to all vertices, this method must be modified for hardware rendering with limited onboard memory. Finally, we demonstrate implementation results for a variety of VRML models with up to two orders of magnitude compression.
Cardiotoxic mechanisms and interrelationships of cocaine: including a single case depicting several of these mechanisms (1998)

The underlying mechanisms of myocardial infarction as a result of cocaine abuse appear to be multifactorial. The various cardiotoxic mechanisms and interrelationships of cocaine are fully reviewed, and a chart has been reconstructed to give the reader a clearer understanding of them. Moreover, an unusual case of a 29-year-old male cocaine abuser is presented because it illustrates many of the reported cardiotoxic effects, all of which are present in the same individual.
Experimental characterization of ranging in IEEE802.15.4a using a coherent reference receiver (2009)

Real time locating systems (RTLS) and wireless sensor networks are currently a hot and challenging research topic. Ultra wideband (UWB) shows promising properties for these systems, such as low-power transmitter designs and highly accurate ranging, where cm-level accuracy is achievable even in multipath intensive environments. A high-performance reference receiver architecture based on coherent processing is presented in this paper. It is used to define quality metrics of the received signals, as for example peak signal to noise ratio (PSNR) and line-of-sight signal to noise ratio (LSNR) for ranging, and Eb/N0 for communication. These metrics are used to evaluate the experimental data in their quality and their ranging performance. Furthermore, performance trade-offs w.r.t. system parameter and receiver architecture choices, in particular for non-coherent receivers, can be analyzed. In this work, the reference receiver is verified experimentally using IEEE 802.15.4a compliant signals. The ranging performance is correlated to the signal-to-noise ratios for an indoor line-of-sight measurement campaign.