gebhart/patrepeval huggingface dataset:
A COMPARISON OF MOLECULAR- AND HISTOPATHOLOGICAL-DIAGNOSES OF RENAL TRANSPLANT INDICATION BIOPSIES (2020)

Background: Kidney transplantation (KT) relies heavily on histologic examination of biopsies for identifying T cell mediated rejection (TCMR) and antibody mediated rejection (ABMR), which is problematic in terms of subjectivity, reproducibility, and even validity of the rules. Transplant medicine needs new diagnostic approaches to guide clinical management and prevent graft loss. Methods: This study was conducted as part of INTERCOMEX (The International Collaborative Microarray Study extension study), a prospective study that aimed to assess the feasibility of real time molecular microscope diagnostic system (MMDx) biopsy assessment by using microarrays. Biopsy samples in each center were immediately stabilized in RNAlater (Qiagen, Mississauga, Canada) and sent by courier to be processed (RNA extraction and labeling, microarray assessment, and normalization of the measurements with the reference set biopsy samples) and analyzed by using predefined algorithms. The classifier output is a score between 0.0 and 1.0, reflecting the probability that a biopsy is TCMR or ABMR. We assigned biopsies above a score of 0.1 as molecular TCMR and 0.2 as molecular ABMR.Results: Considering histology showing T-cell mediated rejection (TCMR), a total 23 patients consisted with histology positive, molecular score positive 6, histology positive, molecular score negative 7, histology negative, molecular score positive 3, and histology negative, molecular score negative 7. Thus in 7/13(54%) of biopsies called TCMR by histology did not have a molecular signal, and 3/9(33%) of biopsies with a molecular signal were not called TCMR by histology. All 9 biopsies with ABMR scores < 0.2 assessed as non-AMBR by histology. When the score was > 0.5, all 7 patients were assigned a diagnosis of ABMR in histologic features. 2 of 7 patients who had scores between 0.2 and 0.5 assessed as non-AMBR by histology. Conclusion: Molecular assessment is feasible and offers a useful new dimension in biopsy interpretation. Discrepancies between molecular scores and histology maybe be due to ambiguity in histologic diagnosis of TCMR.
Software Didattico per l'Emulazione di Sistemi di Comunicazione (2006)

Con LabVIEW 7.1, LabVIEW Application Builder 7.1 e LabVIEW Run-Time Engine 7.1 sono stati realizzati applicativi didattici interattivi che emulano il funzionamento di strumentazione per misure su sistemi di telecomunicazioni, in modo da consentire agli studenti di operare come se stessero utilizzando gli apparati reali.
Synthesis and Platinum Coordination Chemistry of the Perfluoroalkyl Acceptor Pincer Ligand 1,3-(CH2P(CF3)2)2C6H4 (2008)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionSynthesis and Platinum Coordination Chemistry of the Perfluoroalkyl Acceptor Pincer Ligand 1,3-(CH2P(CF3)2)2C6H4Jeramie J. Adams, Ade Lau, Navamoney Arulsamy, and Dean M. RoddickCite this: Inorg. Chem. 2008, 47, 22, 10796Publication Date (Web):October 20, 2008Publication History Received8 October 2008Published online21 October 2008Published inissue 17 November 2008https://pubs.acs.org/doi/10.1021/ic8019217https://doi.org/10.1021/ic8019217correctionACS PublicationsCopyright © 2008 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views725Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (40 KB) Get e-AlertscloseSUBJECTS:Alkyls,Coordination chemistry,Ligands,Platinum Get e-Alerts
Functional Analysis of Monocyte Subsets in Surgical Sepsis (1998)

Sepsis results in a significant monocytosis and suppression of HLA-DR receptor expression, which are correlating with sepsis severity and outcome. A significant shift toward FcR+ Mphi subsets can be found. This subpopulation resembles the previously described "angry macrophage" that is characterized by high proinflammatory cytokine synthesis and suppressed antigen presentation and that contributes to a disruption of adequate Mphi/T-cell interaction, rendering the host anergic toward opportunistic infections. The extend of HLA-DR suppression and the shift toward FcR+ Mphi might characterize a high risk patient subpopulation, which could benefit from immunomodulatory strategies.
An Evolutionarily Conserved Family of Hsp70/Hsc70 Molecular Chaperone Regulators (1999)

Heat Shock Protein 70 kDa (Hsp70) family molecular chaperones play critical roles in protein folding and trafficking in all eukaryotic cells. The mechanisms by which Hsp70 family chaperones are regulated, however, are only partly understood. BAG-1 binds the ATPase domains of Hsp70 and Hsc70, modulating their chaperone activity and functioning as a competitive antagonist of the co-chaperone Hip. We describe the identification of a family of BAG-1-related proteins from humans (BAG-2, BAG-3, BAG-4, BAG-5), the invertebrate Caenorhabditis elegans (BAG-1, BAG-2), and the fission yeast Schizosaccharomyces pombe (BAG-1A, BAG-1B). These proteins all contain a conserved approximately 45-amino acid region near their C termini (the BAG domain) that binds Hsc70/Hsp70, but they differ widely in their N-terminal domains. The human BAG-1, BAG-2, and BAG-3 proteins bind with high affinity (KD congruent with 1-10 nM) to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The findings suggest opportunities for specification and diversification of Hsp70/Hsc70 chaperone functions through interactions with various BAG-family proteins.
Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse (2019)

While the presence and abundance of the major oxysterols and cholestenoic acids in the circulation is well established, minor cholesterol metabolites may also have biological importance and be of value to investigate. In this study by observing the metabolism of deuterium-labelled cholesterol in the pdgfb<sup>ret/ret</sup> mouse, a mouse model with increased vascular permeability in brain, and by studying the sterol content of plasma from the CYP46A1 transgenic mouse overexpressing the human cholesterol 24S-hydroxylase enzyme we have been able to identify a number of minor cholesterol metabolites found in the circulation, make approximate-quantitative measurements and postulate pathways for their formation. These "proof of principle" data may have relevance when using mouse models to mimic human disease and in respect of the increasing possibility of treating human neurodegenerative diseases with pharmaceuticals designed to enhance the activity of CYP46A1 or by adeno-associated virus delivery of CYP46A1.
Difficult Mask Ventilation and Neuromuscular Blockade (2009)

We thank Drs. Myatt and Patel for their interest in our data and comments. We agree that detailed, controlled data collection regarding the ease or difficulty of mask ventilation before and after administration of neuromuscular blockade would be of great interest. Unfortunately, as our original manuscript mentioned,1collecting these data using a large observational dataset is difficult. Aggregation of a 50,000-patient dataset has necessary limitations. Although observational data are exceptional for establishing the real-world effectiveness of different clinical management strategies, they are suboptimal for evaluating the optimal efficacy of a specific strategy under ideal circumstances.2It is not feasible to use a large observational dataset to define the impact of neuromuscular blockade on mask ventilation because of several issues: First, asking providers to document additional elements and attempt mask ventilation before neuromuscular blockade solely for research purposes may require institutional review board evaluation and patient consent. Second, the acuity of the induction period demands a parsimonious approach to documentation in general. Third, it would be difficult to control confounding clinical factors such as depth of anesthesia, dosage of neuromuscular blockade, experience of providers, mask ventilation technique, and timing of mask ventilation attempts.Goodwin performed a prospective, controlled trial evaluating the impact of neuromuscular blockade in 30 patients with normal airways.3Contrary to our clinical experience and that espoused by Dr. Myatt, they found that neuromuscular blockade did not alter the efficacy of mask ventilation, measured by tidal volume. Because the studied population was limited to patients with normal airways, everyday clinicians are left to make decisions without data. Patients exhibiting risk factors for difficult mask ventilation such as obesity, limited jaw protrusion, bearded facial hair, advanced age, oropharyngeal disproportion, and a history of snoring4may be a population worthy of a controlled, prospective study. Such a study would prove to be time-consuming, expensive, difficult, and impractical, given the low incidence. Until then, our observational data describing the use of neuromuscular blockade in patients with impossible mask ventilation may have to suffice.*University of Michigan Medical School, Ann Arbor, Michigan. sachinkh@med.umich.edu
Prediction of velopharyngeal orifice area: a re-examination of model experimentation. (1980)

Warren has advanced a modification of the hydrokinetic equation for predicting velopharyngeal orifice area (Warren and DuBois, 1964). In the present work, this equation was subjected to extensive controlled model experimentation. The results of this experimentation show that, given the pressure differential across the orifice and the rate of airflow through the orifice, accurate predictions can be made of the area of the velopharyngeal port. These results were interpreted to provide strong support for both clinical and research use of the hydrokinetic equation for predicting velopharyngeal orifice area.
The Reaction of EDTA With Metallothionein and its SeparateClusters: Complex Kinetic Behavior With Novel ProteinConcentration Dependence (1994)

This article has no abstract.
Partial discharge characteristics of electrical trees in XLPE power cables (2011)

This paper studies the initiation process and the PD characteristics of electrical trees, and proposes a new method to recognize the growth state of electrical trees. The experiment result show that the electrical trees PD energy mainly concentrated in the -40°~90° and 120°~250° of 5MHz~7.5MHz, -20°~90° and 150~250° of 7.5MHz~10MHz. With the dense increase of the electrical trees, the more PD energy will be found in the frequency 7.5MHz~10MHz. At the first development stage of electrical trees, the PD energy mainly located at the frequency 5MHz~7.5MHz, when electrical trees develop to the next stage, the more PD energy will be found at the frequency 7.5MHz~10MHz.
CNN-based virtual microphone signal estimation for MPDR beamforming in underdetermined situations (2019)

In this paper, we propose a novel approach to virtually increasing the number of microphone elements between two real microphones to improve speech enhancement performance in underdetermined situations. The virtual microphone technique, with which virtual signals in the audio signal domain are estimated by linearly interpolating the phase and nonlinearly interpolating the amplitude independently on the basis of β-divergence, has been recently proposed and experimentally shown to be effective in improving speech enhancement performance. Furthermore, it has been reported that the performance tends to improve as the nonlinearity is improved. However, one drawback of this method is that the interpolation is employed in each time-frequency bin independently, in which the spectral and temporal structures of speech signals are ignored. To address this problem and improve the nonlinearity, motivated by the high capability of neural networks to model nonlinear functions and speech spectrograms, in this paper, we propose an alternative method of amplitude interpolation. In this method, we employ a convolutional neural network as an amplitude estimator that minimizes the mean squared error between the outputs of a minimum power distortionless response (MPDR) beamformer and the target speech signals. The experimental results revealed that the proposed method showed high potential for improving speech enhancement performance, which was not only superior to that of the conventional virtual microphone technique but also the performance in the corresponding determined situation.
Spectral-based quantitative ultrasound imaging: A model free approach (2018)

Quantitative ultrasound (QUS) imaging can improve the diagnostic capabilities of ultrasound. Spectral-based QUS approaches utilize backscattered ultrasound signals to extract additional information about tissue state. These technique have traditionally relied on scattering models to differentiate tissue state. However, the use of machine learning approaches may obviate the need for models. A model-based and model-free (principle component analysis (PCA)) approach to spectral-based QUS were compared for their ability to differentiate fatty from non-fatty liver in a rabbit model. PCA was observed to provide better differentiation of fatty from non-fatty liver, i.e., PCA predicted fatty liver 86% of the time versus 36% for model-based. In addition, three calibration approaches for spectral-based QUS were compared: the traditional reference phantom, reference free, and an in situ calibration target. To test the calibration procedures, a phantom was scanned with and without a lossy layer placed on top and integrated backscatter coefficients (IBSCs) were calculated from the scattered data. Utilizing an in situ calibration target provided the ability to account for transmission losses and attenuation. The root mean square error between IBSCs estimated from the phantom with and without the lossy layer were 8.28 for the reference phantom versus 1.24 for the in situ calibration approach.
Impacto del proceso formador sobre el desempeño estudiantil en la toma de decisiones clínicas informadas en la evidencia (2016)

Fil: Probe, C. Universidad de Buenos Aires. Facultad de Odontología. Odontología Preventiva y Comunitaria; Argentina.
Peculiarities of electronic structure and chemical bonding in iron and cobalt metal complexes of porphyrazine and tetra(1,2,5-thiadiazole)porphyrazine (2020)

The geometrical and electronic structures of iron and cobalt metal complexes of porphyrazine and tetra(1,2,5-thiadiazole)porphyrazine in ground and low-lying excited electronic states were determined by DFT calculations and the complete active space (CASSCF) method with following accounting dynamic correlation by multiconfigurational quasidegenerate second-order perturbation theory (MCQDPT2). A geometrical structure of D[Formula: see text] symmetry has been obtained for all four complexes. According to data obtained by the MCQDPT2 method, the complexes of cobalt and iron possess the ground states 2 A[Formula: see text] and 3 A[Formula: see text], respectively, and wave functions of the ground states have the form of a single determinant. It is shown that the crystal field theory (CFT) can be used to describe the sequence of electronic states of the investigated complexes. The nature of the bonds between metal atoms and nitrogen atoms has been described using the analysis of the electron density distribution in the frame of Bader’s quantum theory of atoms in molecule (QTAIM).
Diversity of a stable enrichment culture which is useful for silage inoculant and its succession in alfalfa silage (2006)

Alfalfa is a kind of forage that is difficult to ensile for good quality. Therefore, inoculants are always used to enhance the preservation of alfalfa silage. Through continuous restricted subcultivation, a lactic acid bacteria community (Al2) was selected from well-fermented alfalfa silage, which sharply decreased the pH level and produced a large amount of lactic acid. The adding of Al2 to alfalfa at ensiling resulted in a more rapid drop in pH and higher levels of lactic acid, and it also reduced the ammonia-nitrogen content significantly (P < 0.01). Plate isolation, denaturing gradient gel electrophoresis (DGGE) and the construction of a 16S rRNA gene clone library were used to identify the composition diversity of the Al2 community; seven strains were detected in the community, the predominant strain belonging to Lactobacillus plantarum. Samples of alfalfa silages of duration 0, 2, 5, 10, 20 and 30 days were studied with DGGE analysis. The DGGE band patterns of Al2-treated and non inoculated were rather different, and the components of Al2 were the dominant bacteria in Al2-treated silages, especially L. plantarum, while Pediococcus pentosaceaus was predominant in naturally fermented alfalfa silage.
Faculty Opinions recommendation of Human genomic deletions mediated by recombination between Alu elements. (2006)

Recombination between Alu elements results in genomic deletions associated with many human genetic disorders. Here, we compare the reference human and chimpanzee genomes to determine the magnitude of this recombination process in the human lineage since the human-chimpanzee divergence 6 million years ago. Combining computational data mining and wet-bench experimental verification, we identified 492 human-specific deletions (for a total of 400 kb) attributable to this process, a significant component of the insertion/deletion spectrum of the human genome. The majority of the deletions (295 of 492) coincide with known or predicted genes (including 3 that deleted functional exons, as compared with orthologous chimpanzee genes), which implicates this process in creating a substantial portion of the genomic differences between humans and chimpanzees. Overall, we found that Alu recombination-mediated genomic deletion has had a much higher impact than was inferred from previously identified isolated events and that it continues to contribute to the dynamic nature of the human genome.
Entanglement in blends of monodisperse star and linear polystyrenes. 1. Dilute blends (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEntanglement in blends of monodisperse star and linear polystyrenes. 1. Dilute blendsHiroshi Watanabe, Hirotsugu Yoshida, and Tadao KotakaCite this: Macromolecules 1988, 21, 7, 2175–2183Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/ma00185a050https://doi.org/10.1021/ma00185a050research-articleACS PublicationsRequest reuse permissionsArticle Views130Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Measurement and classification of humans and bots in internet chat (2008)

The abuse of chat services by automated programs, known as chat bots, poses a serious threat to Internet users. Chat bots target popular chat networks to distribute spam and malware. In this paper, we first conduct a series of measurements on a large commercial chat network. Our measurements capture a total of 14 different types of chat bots ranging from simple to advanced. Moreover, we observe that human behavior is more complex than bot behavior. Based on the measurement study, we propose a classification system to accurately distinguish chat bots from human users. The proposed classification system consists of two components: (1) an entropy-based classifier and (2) a machinelearning-based classifier. The two classifiers complement each other in chat bot detection. The entropy-based classifier is more accurate to detect unknown chat bots, whereas the machine-learning-based classifier is faster to detect known chat bots. Our experimental evaluation shows that the proposed classification system is highly effective in differentiating bots from humans. 1