gebhart/patrepeval huggingface dataset:
Handling startling circumstances with IRM scheduler of real-time systems (2017)

There are many vital real-time systems such as avionics, mission-critical, industrial control, and space-mission, which cannot tolerate any request overruns. Safeness analysis of such systems is directly dependent on the scheduling strategy being used. Rate-monotonic and earliest deadline first are the leading scheduling strategies for these systems. Before deployment, it is essential to make sure no task misses occur for such hard real-time systems. This is usually done by formally proving the safeness of the system for the given set of tasks. Besides, a scheduler is preferred which performs better in unexpected situations such as when a transient fault occurs. The purpose of this paper is to first reveal some new behaviours of the intelligent rate-monotonic scheduler and then evaluate its performance in unexpected situations. Simulation results show that it performs better than both rate-monotonic and earliest deadline first in such situations.
Fatty fish-induced changes in membrane lipid composition and viscosity of human erythrocyte suspensions (1986)

The effect of a daily supplement of 75-100 g fatty fish, providing 3 g of omega 3 fatty acids, on the lipid composition and deformability of erythrocytes was studied in six healthy male subjects. After 4 weeks of the fish supplementation the mean degree of unsaturation, expressed as double bond index, of erythrocyte phosphatidyl choline (PC) and phosphatidyl ethanolamine (PE) had increased significantly by 10% and 4%, respectively. The mean cholesterol/phospholipid ratio (C/P ratio) in the membranes had increased by 28% (p less than 0.001). No change was seen in the distribution of the four major phospholipid classes. After withdrawal of the supplement for 4 weeks the changes in PC were reversed, but the changes in PE persisted and the mean C/P ratio still was higher than basal by 16% (p less than 0.01). The effect on the C/P ratio by the fatty fish is in contrast with the previously observed lack in effect of cod-liver oil. The viscosity of erythrocyte suspensions with a packed cell volume fraction of 0.80 and measured at shear rates less than or equal to 8.11 s-1 was decreased after the fish. We suggest that the fall in the viscosity of erythrocyte suspensions, reflecting increased cell deformability, is probably due to the change in the fatty acid composition of erythrocyte PC.
Evolutionary analysis and interaction prediction for protein-protein interaction network in geometric space (2017)

Prediction of protein-protein interaction (PPI) remains a central task in systems biology. With more PPIs identified, forming PPI networks, it has become feasible and also imperative to study PPIs at the network level, such as evolutionary analysis of the networks, for better understanding of PPI networks and for more accurate prediction of pairwise PPIs by leveraging the information gained at the network level. In this work we developed a novel method that enables us to incorporate evolutionary information into geometric space to improve PPI prediction, which in turn can be used to select and evaluate various evolutionary models. The method is tested with cross-validation using human PPI network and yeast PPI network data. The results show that the accuracy of PPI prediction measured by ROC score is increased by up to 14.6%, as compared to a baseline without using evolutionary information. The results also indicate that our modified evolutionary model DANEOsf-combining a gene duplication/neofunctionalization model and scale-free model-has a better fitness and prediction efficacy for these two PPI networks. The improved PPI prediction performance may suggest that our DANEOsf evolutionary model can uncover the underlying evolutionary mechanism for these two PPI networks better than other tested models. Consequently, of particular importance is that our method offers an effective way to select evolutionary models that best capture the underlying evolutionary mechanisms, evaluating the fitness of evolutionary models from the perspective of PPI prediction on real PPI networks.
An approach to mapping machining feature to manufacturing feature volume based on geometric reasoning for process planning (2015)

Efficient construction in three-dimensional working procedure model has an important effect on the efficiency and quality of machining process planning. This article proposes an algorithm to mapping machining features to manufacturing feature volumes from B-rep of mechanical part, and then, the working procedure models are generated. The mapping strategy is performed in three steps. In the first step, three types of machining features, such as depression feature, protrusion feature and transition feature, are introduced. In the second step, the edges of the chosen seed face and its neighboring faces are searched in order to generate the machining feature faces. The last step applies a closure to the machining feature faces to generate a compact solid by applying additional neighboring faces and their extensions. Then, the working procedure models are formed by combining the mapped manufacturing feature volumes with the final parts model. Compared with the existing working procedure model’s generation methods, this approach can avoid the unnecessary conversions from the engineering drawing to three-dimensional process models and from the machining knowledge to the modeling knowledge, which can greatly reduce the planning time on modeling. To validate the feasibility and validity of this approach, two machined parts with complex machining features are tested in the developed prototype computer-aided process planning system.
1372: DEVELOPMENT OF A ROBUST BIOMARKER PREDICTIVE MODEL FOR DEATH IN ICU PATIENTS WITH SIRS AND SEPSIS (2016)

Mikacenic, Carmen; Price, Brenda; Harju-Baker, Susanna; Katz, Ronit; Himmelfarb, Jonathan; Liles, W; Wurfel, Mark
Cover Feature: Self‐Immolation of a Bacterial Dehydratase Enzyme by its Epoxide Product (Chem. Eur. J. 36/2020) (2020)

Enzyme self-immolation: The cover shows how the type I dehydroquinase enzyme catalyzes its self-destruction by transforming an unreactive 2-hydroxyethylammonium derivative into an epoxide that triggers the covalent modification of the catalytic lysine residue. This process is responsible of the in vitro anti-virulence activity of the ligand. More information can be found in the Full Paper by C. González-Bello, et al. on page 8035.
Flow Fingerprinting Fecal Pollution and Suspended Solids in Stormwater Runoff from an Urban Coastal Watershed (2006)

Field studies were conducted to characterize the concentration vs streamflow relationships (or "flow fingerprints") of fecal pollution and suspended solids in stormwater runoff from the Santa Ana River watershed, the largest watershed in southern California. The concentrations of fecal indicator bacteria and F+ coliphages (viruses infecting E. coli) exhibit little-to-no dependence on streamflow rates, whereas the concentrations of total suspended solids (TSS) exhibit a very strong (power-law) dependence on streamflow rates. The different flow fingerprints observed for fecal pollutants, on one hand, and TSS, on the other hand, reflect different sources and transport pathways for these stormwater constituents. The flow-independent nature of fecal indicator bacteria and F+ coliphages is consistent with the idea that these contaminants are ubiquitously present on the surface of the urban landscape and rapidly partition into the surface water as the landscape is wetted by rainfall. The flow-dependent nature of TSS, on the other hand, is usually ascribed to the shear-induced erosion of channel bed sediments and/or the expansion of drainage area contributing to runoff. The apparent ubiquity of fecal indicator bacteria and F+ coliphages, together with the very high storm-loading rates of fecal indicator bacteria and the low detection frequency of human adenovirus and human enterovirus, suggest that fecal pollution in stormwater runoff from the Santa Ana River watershed is primarily of nonhuman waste origin.
Characterization of Indoor-Outdoor Aerosol Concentration Relationships during the Fresno PM Exposure Studies (2001)

Particle size distributions were measured indoors and outdoors of a single, detached residence during the Fresno particulate matter exposure studies in winter (February 1-28, 1999) and spring (April 18-May 16, 1999). Data was collected for particle sizes ranging from about 0.01 to 2.5
The robustness of persistent homology of brain networks to data acquisition‐related non‐neural variability in resting state fMRI (2023)

There is increasing interest in investigating brain function based on functional connectivity networks (FCN) obtained from resting-state functional magnetic resonance imaging (fMRI). FCNs, typically obtained using measures of time series association such as Pearson's correlation, are sensitive to data acquisition parameters such as sampling period. This introduces non-neural variability in data pooled from different acquisition protocols and MRI scanners, negating the advantages of larger sample sizes in pooled data. To address this, we hypothesize that the topology or shape of brain networks must be preserved irrespective of how densely it is sampled, and metrics which capture this topology may be statistically similar across sampling periods, thereby alleviating this source of non-neural variability. Accordingly, we present an end-to-end pipeline that uses persistent homology (PH), a branch of topological data analysis, to demonstrate similarity across FCNs acquired at different temporal sampling periods. PH, as a technique, extracts topological features by capturing the network organization across all continuous threshold values, as opposed to graph theoretic methods, which fix a discrete network topology by thresholding the connectivity matrix. The extracted topological features are encoded in the form of persistent diagrams that can be compared against one another using the earth-moving metric, also popularly known as the Wasserstein distance. We extract topological features from three data cohorts, each acquired at different temporal sampling periods and demonstrate that these features are statistically the same, hence, empirically showing that PH may be robust to changes in data acquisition parameters such as sampling period.
Are all n-3 polyunsaturated fatty acids created equal? (2009)

N-3 Polyunsaturated fatty acids have been shown to have potential beneficial effects for chronic diseases including cancer, insulin resistance and cardiovascular disease. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in particular have been studied extensively, whereas substantive evidence for a biological role for the precursor, alpha-linolenic acid (ALA), is lacking. It is not enough to assume that ALA exerts effects through conversion to EPA and DHA, as the process is highly inefficient in humans. Thus, clarification of ALA's involvement in health and disease is essential, as it is the principle n-3 polyunsaturated fatty acid consumed in the North American diet and intakes of EPA and DHA are typically very low. There is evidence suggesting that ALA, EPA and DHA have specific and potentially independent effects on chronic disease. Therefore, this review will assess our current understanding of the differential effects of ALA, EPA and DHA on cancer, insulin resistance, and cardiovascular disease. Potential mechanisms of action will also be reviewed. Overall, a better understanding of the individual role for ALA, EPA and DHA is needed in order to make appropriate dietary recommendations regarding n-3 polyunsaturated fatty acid consumption.
Iteration of a MEMS-based, Ka-band, 16-element sub-array (2011)

The Aviation and Missile Research, Development and Engineering Center has been involved in a research and development program aimed at furthering phased arrays for both tactical seekers and communication links. The program has been pursuing both MicroElectroMechanical Systems (MEMS) and MMIC-based phase shifters with an overall goal of affordability traded against performance. In a collaborative effort with the Communications Electronics Research, Development and Engineering Center (CERDEC), the AMRDEC has worked to improve the maturity of Radio Frequency (RF) MEMS devices for use in phase shifters for phased arrays. This paper will present an iteration of the microwave antenna consisting of a 16-element phased sub-array with RF MEMS-based phase shifters, which was developed and tested on a previous task. On this task, the microwave Transmit/Receive (T/R) circuitry was added to the slat assembly to provide amplification on both transmit and receive. This paper will present the lessons learned and actions to be addressed before MEMS is a viable option for phase shifting. Some of the items of significance in this design are the MEMS phase shifters, the 16-way Taylor weighted power divider, the Vivaldi antennas and the microwave T/R circuitry. Resulting antenna patterns at different frequencies and multiple steering angles will be presented. A discussion of the results of the test and future plans will be explored. The background work for this paper was presented at the 2010 IEEE Aerospace Conference. This paper includes that information along with complete documentation of the laboratory evaluation.
Future Directions in Shoulder Arthroplasty (2008)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Literature Review of Mobility as a Service (2022)

The number of publications about mobility as a service (MaaS) has increased rapidly in the past years, spreading into various fields. In this paper, a total of 127 scientific publications about MaaS are reviewed and categorized into an overarching thematic framework in order to highlight key areas of research and further potential. Three research questions are highlighted in this review: (1) which topics are discussed in the existing MaaS literature? (2) what are the main results in the specific fields? and (3) where are gaps for further research? Publications have focused substantially on the topics of the market, users, data and technology, and the impact on the transportation system. The review shows that, regarding the concept, multi-level approaches have been established for the organization and cooperation of the actors involved, showing different levels of integration of public and private actors on a regional and supra-regional level. Various groups have already been identified as potential users, but the relatively low willingness to pay and the requirements regarding the individualization of mobility services pose problems that have not yet been solved. There is also a constant and unsolved challenge regarding the sensitive motion data that must be stored and processed. Significant research is still needed, including assessments of the impact of MaaS and what effects the service will have on the established use of transport modes, as well as how packages need to be designed and priced in order to optimally reach users.
Application of hollow-fiber liquid microextraction coupled with a surfactant ion pair solvent for the study of acrylamide and glycidamide in high temperature processed medicinal plant materials (2018)

A fresh hollow-fiber liquid microextraction coupled with surfactant ion pair solvent approach for the separation and extraction of acrylamide (AA) and glycidamide (GA) in high temperature processed medicinal plant materials (HTPMPMs) is described.
Integrated Stretch Processed S-Band Digital Radar System (2018)

A stretch processed radar system is presented in this paper. The radar system operates at S-band and employs stretch processing. Stretch processing helps a radar system to process wideband signals to increase its resolution, while relaxing its analog-to-digital converter's sampling rate requirement. The reported radar system exhibits a high dynamic range which enables it to be used in variety of applications such as surveillance systems. Furthermore, the radar system architecture comprises of multiple receiver channels which enable the radar to detect objects of interests at certain angular locations and reject jammers. The digital radar testbed was built using microwave components. Moreover, the radar system is integrated on a single die chip using IBM 180 nm CMOS process with a low power consumption, small form factor, and high performance.
A multimodal tensor-based late fusion approach for satellite image search in Sentinel 2 images (2021)

Earth Observation (EO) Big Data Collections are acquired at large volumes and variety, due to their high heterogeneous nature. The<br> multimodal character of EO Big Data requires eective combination of multiple modalities for similarity search. We propose a late fusion mechanism of multiple rankings to combine the results from several uni-modal searches in Sentinel 2 image collections. We st create a K-order tensor from the results of separate searches by visual features, concepts, spatial and temporal information. Visual concepts and features are based on a vector representation from Deep Convolutional Neural Networks. 2D-surfaces of the K-order tensor initially provide candidate retrieved results per ranking position and are merged to obtain the nal list of retrieved results. Satellite image patches are used as queries in order to retrieve the most relevant image patches in Sentinel 2 images. Quantitative and qualitative results show that the proposed method outperforms search by a single modality and other late fusion methods.
A Phase Response Curve to Single Bright Light Pulses in Human Subjects (2003)

The circadian pacemaker is differentially sensitive to the resetting effects of retinal light exposure, depending upon the circadian phase at which the light exposure occurs. Previously reported human phase response curves (PRCs) to single bright light exposures have employed small sample sizes, and were often based on relatively imprecise estimates of circadian phase and phase resetting. In the present study, 21 healthy, entrained subjects underwent pre- and post-stimulus constant routines (CRs) in dim light (approximately 2-7 lx) with maintained wakefulness in a semi-recumbent posture. The 6.7 h bright light exposure stimulus consisted of alternating 6 min fixed gaze (approximately 10 000 lx) and free gaze (approximately 5000-9000 lx) exposures. Light exposures were scheduled across the circadian cycle in different subjects so as to derive a PRC. Plasma melatonin was used to determine the phase of the onset, offset, and midpoint of the melatonin profiles during the CRs. Phase shifts were calculated as the difference in phase between the pre- and post-stimulus CRs. The resultant PRC of the midpoint of the melatonin rhythm revealed a characteristic type 1 PRC with a significant peak-to-trough amplitude of 5.02 h. Phase delays occurred when the light stimulus was centred prior to the critical phase at the core body temperature minimum, phase advances occurred when the light stimulus was centred after the critical phase, and no phase shift occurred at the critical phase. During the subjective day, no prolonged 'dead zone' of photic insensitivity was apparent. Phase shifts derived using the melatonin onsets showed larger magnitudes than those derived from the melatonin offsets. These data provide a comprehensive characterization of the human PRC under highly controlled laboratory conditions.
Accurate Strain Gauge Limits Through Geometry Mistuning Modeling (2018)

Safe engine operation is ensured by setting safety limits on rotor airfoil-mounted strain gauges that monitor the dynamic response of the component. Traditionally, strain gauge limits are generated using geometry obtained from an “as-designed” nominal model, in which finite element analysis is used to compute the static and modal stresses. Predicted modal stresses of the cyclic analysis are used to optimize strain gauge locations to ensure modal observational coverage, modal identification, and maximum vibrational stress for each mode. Strain gauge limits are then produced for these optimal strain gauge locations on the tuned finite element model. This described nominal geometry based process is subject to errors associated with airfoil mode-shape variations caused by manufacturing deviations. This paper develops a new process based on as-manufactured geometry measurements from a high-fidelity optical geometry collection system that obtains more accurate strain gauge limits. It will be shown that, because of the variability of blade-to-blade geometry, strain gauge limits can vary significantly between blades. This will be demonstrated by analyzing a mistuned integrally bladed rotor on a sector-by-sector basis. The approach used in this paper has the capability to more accurately place gauges on responsive blades to ensure safe engine operation during testing.
Local Delivery of Paclitaxel to Inhibit Restenosis during Angioplasty of the Leg (2008)

Use of paclitaxel-coated angioplasty balloons during percutaneous treatment of femoropopliteal disease is associated with significant reductions in late lumen loss and target-lesion revascularization. No significant benefit is seen with the use of a paclitaxel-containing contrast medium. (ClinicalTrials.gov number, NCT00156624 [ClinicalTrials.gov].).
Chromatin Regulatory Mechanisms in Pluripotency (2010)

Stem cells of all types are characterized by a stable, heritable state permissive of multiple developmental pathways. The past five years have seen remarkable advances in understanding these heritable states and the ways that they are initiated or terminated. Transcription factors that bind directly to DNA and have sufficiency roles have been most easy to investigate and, perhaps for this reason, are most solidly implicated in pluripotency. In addition, large complexes of ATP-dependent chromatin-remodeling and histone-modification enzymes that have specialized functions have also been implicated by genetic studies in initiating and/or maintaining pluripotency or multipotency. Several of these ATP-dependent remodeling complexes play non-redundant roles, and the esBAF complex facilitates reprogramming of induced pluripotent stem cells. The recent finding that virtually all histone modifications can be rapidly reversed and are often highly dynamic has raised new questions about how histone modifications come to play a role in the steady state of pluripotency. Another surprise from genetic studies has been the frequency with which the global effects of mutations in chromatin regulators can be largely reversed by a single target gene. These genetic studies help define the arena for future mechanistic studies that might be helpful to harness pluripotency for therapeutic goals.
Augmenting organizational memory (1998)

A growing concern for organizations and groups has been to augment their knowledge and expertise. One such augmentation is to provide an organizational memory, some record of the organization's knowledge. However, relatively little is known about how computer systems might enhance organizational, group, or community memory. This article presents Answer Garden, a system for growing organizational memory. The article describes the system and its underlying implementation. It then presents findings from a field study of Answer Garden. The article discusses the usage data and qualitative evaluations from the field study, and then draws a set of lessons for next-generation organizational memory systems.