gebhart/patrepeval huggingface dataset:
Oxidation of GR-S and Other Elastomers (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of GR-S and Other ElastomersJohn O. Cole and James E. FieldCite this: Ind. Eng. Chem. 1947, 39, 2, 174–179Publication Date (Print):February 1, 1947Publication History Published online1 May 2002Published inissue 1 February 1947https://pubs.acs.org/doi/10.1021/ie50446a020https://doi.org/10.1021/ie50446a020research-articleACS PublicationsRequest reuse permissionsArticle Views31Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Theory of ac Space-Charge Polarization Effects in Photoconductors, Semiconductors, and Electrolytes (1953)

A linear theory is developed of the ac behavior of solid or liquid materials containing charge carriers which can move freely within the material but cannot leave it through the electrodes. The theory applies for any degree of dissociation of neutral centers and recombination of positive and negative charge carriers, but these carriers are assumed to have been produced by dissociation from only one species of neutral center. The mobile carriers may be electrons, positive holes, positive ions, negative ions, positive ion vacancies, or negative ion vacancies. The general solution for the admittance of the material is obtained for an arbitrary ratio between the mobilities of positive and negative carriers, but, because of the complexity of the result, it is only discussed in detail in the present paper for the following special cases: (a) charge carriers of only one sign mobile, arbitrary recombination time; (b) charge carriers of both signs mobile with the same mobility, arbitrary recombination time; and (c) charge carriers of both signs mobile with unequal mobilities and very short recombination time. In case (a), two dispersion regions may appear, with that at lower frequencies arising from recombination and the other from the finite mobility of the carriers. Both regions follow Debye dispersion curves accurately over a wide frequency range, making it possible to represent the electrical behavior of the material for any recombination time by means of a simple equivalent circuit containing only frequency-independent elements. In cases (b) and (c), only the motional dispersion region appears, and it again follows Debye curves. Finally, the results of the present theory are compared with those of other theories of ac space-charge effects in semiconductors and electrolytes.
A 1.6-GHz delta-sigma modulated fractional-N frequency synthesizer (2005)

The goal of this work is to design a high speed, low power consumption, and low noise RF frequency synthesizer. It can be applied to the RF front-end architecture of the IEEE 802.11 b/g channels. In this work, the VCO is an LC-tank oscillator to get the low noise performance, and an all digital delta-sigma modulator, which controls the divider of the synthesizer, is designed to present the channel selection and the fractional division ratio. Basing on the theory of phase-locked loop, the concepts, several different architectures, and the implementation of the fractional-N frequency synthesizer are given. The fractional-N frequency synthesizer is fabricated in a 1.8V, 0.18/spl mu/m CMOS technology, and consumes 29.05 mW in the operating frequency of 1.6 GHz.
Flow Cytometric Analysis and Sorting of Live Female Rat Anterior Pituitary Cell Types by Forward Angle and Perpendicular Light Scatter: Effect of 17β-Estradiol* (1986)

Administration of physiological concentrations of 17 beta-estradiol (E2) to ovariectomized rats resulted in changes in the forward angle light scatter (FALS) and perpendicular light scatter (PLS) signals of anterior pituitary lobe cells. One day after steroid treatment some cells showed increases in PLS signals to an intermediate ridge position lying between the two ridges seen for cells prepared from oil-treated ovariectomized rats. Over the first 5 days of E2 treatment, the major effect was a progressive increase in the FALS signal of cells in this intermediate ridge position. Increases in PLS signals continued over the 12-day treatment period. Since the results of a cell sorting experiment showed that PRL cells predominated in the intermediate scatter ridge, it was concluded that E2 increases both size (FALS) and secretory granule content (PLS) of mammotrophs. Cells in the low and high scatter regions were unaffected by E2. Those in the low scatter region were shown, by both electron microscopy and light microscopic immunochemistry, to be enriched in agranular, unstained endothelial-follicular cells. The high-scatter region contained predominantly GH cells. Administration of E2 to pituitary cells cultured in serum-free or serum-containing media for 1-12 days had no effect on the FALS-PLS bivariate distribution. However, the light scatter ridges produced from cells in culture were compressed into a single ridge of narrow PLS and broad FALS signal intensity with increasing time in culture.
Altered gene expression in the transition phase by disruption of a Na+/H+antiporter gene (shaA) inBacillus subtilis (2004)

The shaA gene (sodium-hydrogen antiporter gene A, identical to mrpA) is largely responsible for Na+ extrusion in Bacillus subtilis. The disruption of shaA combined with a low concentration of NaCl completely abolishes sporulation but allows normal growth. To investigate the role of shaA and shaA-mediated sodium ion homeostasis in sporulation, we performed a comprehensive study of expression profiles of eight alternative sigma factors, sigmaB and the seven extracytoplasmic function sigma factors (sigmaM, sigmaV, sigmaW, sigmaX, sigmaY, sigmaZ, and sigmaYlaC) in an attempt to determine the global change of gene expression that results from a disturbance of Na+ homeostasis caused by shaA disruption. Induction of sigmaB activity in the transition phase was impaired in the shaA mutant, and this effect was enhanced in the presence of 30 mM NaCl. Salt stress activation of sigmaB occurred normally in the shaA mutant. sigmaM-, sigmaW-, sigmaX-dependent transcription and sigZ transcription was also induced in the transition phase of the wild-type, which was modulated by shaA disruption. The induction of sigmaM-dependent transcription was enhanced in the shaA mutant, while that of sigmaX-dependent transcription and sigZ transcription was decreased. sigmaW-dependent transcription was increased throughout the growth phase of the shaA mutant, which was consistent with the result of proteome analysis. We conclude that shaA disruption resulted in the modulated induction of alternative sigma factor activities, which would be problematic for the cell upon entering the sporulation stage.
Analysis of fatty acids by negative ion gas chromatography/tandem mass spectrometry: Structural correlations between α-mycolic acid chains and δ-5-monounsaturated fatty acids fromMycobacterium phlei (1988)

The analysis of a complex mixture of monounsaturated fatty acids from mycobacterium phlei is achieved by capillary gas chromatographic separation of their pentafluorobenzyl esters, formation of gas-phase carboxylate anions by electron capture ionization and decomposition of these anions by collision activation. This method allows the structural determination of fatty acid isomers by examination of their collisionally activated dissociation mass-analysed ion kinetic energy spectra. A good correlation is observed between the structure of the unsaturated fatty acids ranging from C24 to C27 and the methyl terminal part of the main chain of diunsaturated mycolic acids.
Synthesis of 6H‐benzo[cd]pyren‐6‐one, a polar constituent of carbon black (1983)

Abstract 6 H ‐Benzo[ cd ]pyren‐6‐one ( 6 ), a potentially carcinogenic constituent of carbon black, can be synthesized smoothly and in good overall yield (49%) from pyrene ( 1 ), by using the reactivity of the pyrene dianion.
Role of κII-A2 Light Chain CDR-3 Junctional Residues in Human Antibody Binding to the Haemophilus influenzae Type b Polysaccharide (1998)

Abstract Abs using the κII-A2 V gene segment predominate the human Ab repertoire to the Haemophilus influenzae b (Hib) polysaccharide (PS). All A2 anti-Hib PS Abs sequenced to date possess a 10-amino acid L chain complementarity-determining region-3 (CDR-3) having an insertional arginine (Arg) at position 95a, the V-J junction. These findings suggest an essential requirement for this conserved Arg residue in determining Hib PS-binding affinity. We examined this requirement by performing chain recombination experiments in which a series of A2 L chains, differing at position 95a, were combined individually with an Fd region known to generate a Hib PS-combining site when paired with an A2-Arg(95a)-Jκ1 V region. Hib PS binding of the recombinant Fabs was evaluated quantitatively using a radioantigen-binding assay. Fabs having A2 L chains with either Arg or lysine in position 95a in combination with Jκ1 gave equivalent and strongest binding to Hib PS. Fabs having A2-Jκ1 L chains with either tyrosine, glycine, alanine, leucine, serine, or threonine in position 95a, or having an A2-Arg(95a)-Jκ3 L chain, gave intermediate binding. Fabs having A2-Jκ1 L chains with glutamate or aspartate at 95a or with no junctional residue showed little or no Hib PS binding. These results demonstrate the importance of L chain junctional residue, as well as Jκ usage and CDR-3 length, in determining Hib PS-binding affinity. Contrary to expectation, an Arg junctional residue is not essential for generating either high or intermediate affinity-binding sites.
Animal Pose Tracking: 3D Multimodal Dataset and Token-based Pose Optimization (2022)

Abstract Accurate tracking of the 3D pose of animals from video recordings is critical for many behavioral studies, yet there is a dearth of publicly available datasets that the computer vision community could use for model development. We here introduce the Rodent3D dataset that records animals exploring their environment and/or interacting with each other with multiple cameras and modalities (RGB, depth, thermal infrared). Rodent3D consists of 200 min of multimodal video recordings from up to three thermal and three RGB-D synchronized cameras (approximately 4 million frames). For the task of optimizing estimates of pose sequences provided by existing pose estimation methods, we provide a baseline model called OptiPose . While deep-learned attention mechanisms have been used for pose estimation in the past, with OptiPose , we propose a different way by representing 3D poses as tokens for which deep-learned context models pay attention to both spatial and temporal keypoint patterns. Our experiments show how OptiPose is highly robust to noise and occlusion and can be used to optimize pose sequences provided by state-of-the-art models for animal pose estimation.
Expression of a Human Cytochrome P450 in Yeast Permits Analysis of Pathways for Response to and Repair of Aflatoxin-Induced DNA Damage (2005)

Aflatoxin B1 (AFB1) is a human hepatotoxin and hepatocarcinogen produced by the mold Aspergillus flavus. In humans, AFB1 is primarily bioactivated by cytochrome P450 1A2 (CYP1A2) and 3A4 to a genotoxic epoxide that forms N7-guanine DNA adducts. A series of yeast haploid mutants defective in DNA repair and cell cycle checkpoints were transformed with human CYP1A2 to investigate how these DNA adducts are repaired. Cell survival and mutagenesis following aflatoxin B1 treatment was assayed in strains defective in nucleotide excision repair (NER) (rad14), postreplication repair (PRR) (rad6, rad18, mms2, and rad5), homologous recombinational repair (HRR) (rad51 and rad54), base excision repair (BER) (apn1 apn2), nonhomologous end-joining (NHEJ) (yku70), mismatch repair (MMR) (pms1), translesion synthesis (TLS) (rev3), and checkpoints (mec1-1, mec1-1 rad53, rad9, and rad17). Together our data suggest the involvement of homologous recombination and nucleotide excision repair, postreplication repair, and checkpoints in the repair and/or tolerance of AFB1-induced DNA damage in the yeast model. Rev3 appears to mediate AFB1-induced mutagenesis when error-free pathways are compromised. The results further suggest unique roles for Rad5 and abasic endonuclease-dependent DNA intermediates in regulating AFB1-induced mutagenicity.
Synthesis of methyl [5,6,8,9,14,‐3 H6]‐hepoxilin B3 and its conversion into methyl [5,6,8,9,14,15‐3H6]‐hepoxilin A3 (1994)

Abstract The selective tritiation of methyl 10(R/S)‐hydroxy‐11(R),12(S)‐epoxyeicosa‐5,8,14‐triynoate into two C 10 ‐epimeric [ 3 H 6 ]‐hepoxilins B 3 methyl esters is described. These compounds are subsequently converted into two C 8 ‐epimeric [ 3 H 6 ]‐hepoxilins A 3 methyl esters by allylic rearrangement under Mitsunobu conditions via corresponding benzoates.
The Impact of the Activated Stroma on Pancreatic Ductal Adenocarcinoma Biology and Therapy Resistance (2012)

Around 95% of patients diagnosed with pancreatic cancer will die of their disease within 5 years, three quarters within a year. The major hurdle in improving prognosis is the lack of a therapeutic time window. Early cancerous lesions are far beneath our threshold of detection. Therefore, at the time of diagnosis even early (T1) tumors can be metastatic and resistant to conventional treatments. Several therapies targeting epithelial tumor cells-all showing impressive results in vitro and in animal experiments-have failed to show relevant effects in clinical trials. This discrepancy between experimental data and clinical reality results mostly from the inefficiency of our current experimental setups in recreating the tumor microenvironment. Forming more than 80% of the tumor mass, the fibrotic stroma of pancreatic ductal adenocarcinoma is not a passive scaffold for the malignant cells but an active player in carcinogenesis. This component is mostly missing in the xeno-/allograft- mouse models. Although tumors are bigger if stellate cells are co-implanted, due to the disproportionate cancer/stromal cell ratio and -possibly- too rapid tumor growth, the stromal reaction is much smaller than in human pancreatic cancer. One the other hand, desmoplasia is present only in some of the genetically engineered mouse models. Clinically, stromal activity of the pancreatic ductal adenocarcinoma has as great an impact on patient prognosis as the lymph node status of the tumor. The exact molecular mechanisms behind this observation remain obscure. However, one possible fundamental biologic explanation could be that selective pressure applied by the stroma leads to the evolution of cancer cells. Consequently, somatic evolution of invasive cancer could be viewed as a sequence of phenotypical adaptations to this barrier, highlighting the importance of the fibrotic tumor microenvironment in the behavior of pancreatic cancer. In this review, the interaction of the epithelial tumor cells with the stroma in humans and in various animal models is scrutinized, and novel therapeutic options for uncoupling cancer-stroma interactions are discussed.
1-(Alkylamino)-guanidines (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1-(Alkylamino)-guanidinesWilliam G. Finnegan, Ronald A. Henry, and G. B. L. SmithCite this: J. Am. Chem. Soc. 1952, 74, 12, 2981–2983Publication Date (Print):June 1, 1952Publication History Published online1 May 2002Published inissue 1 June 1952https://pubs.acs.org/doi/10.1021/ja01132a007https://doi.org/10.1021/ja01132a007research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Terahertz near-field imaging of highly-malignant early-stage breast cancer (2021)

Terahertz (THz) imaging has a potential to intraoperatively diagnose breast cancers in a label-free manner [1].
ChemInform Abstract: One‐Step Synthesis of Stabilized Phosphonates. (1987)

Abstract The phosphonates (III) are obtained from the nitriles, nitroalkanes, and esters (I) on treatment with bases and subsequent phosphonylation with diethyl chlorophosphonate (II).
Imaging of sub-unit-cell structures in the contact mode of the scanning force microscope (1999)

An experimental and theoretical study on the nature of the movement of a scanned tip on a $\ensuremath{\beta}\ensuremath{-}{\mathrm{MoTe}}_{2}$ surface is presented, which examines the consequences of the applied loading force on the resolution of sub-unit-cell structures of a scanning force microscope operated in contact mode. By comparison of experimental and simulated force maps it is found that the so-called ``stick-slip'' movement of the tip depends strongly on the applied loading force. This effect has significant consequences on the resolution of the examined nontrivial unit cell of $\ensuremath{\beta}\ensuremath{-}{\mathrm{MoTe}}_{2}.$
Computational Methods for Predicting Sites of Functionally Important Dynamics (2009)

Understanding and controlling biological function of proteins at the atomic level is of great importance; allosteric mechanisms provide such an interface. Experimental and computational methods have been developed to search for residue mutations that produce changes in function by altering sites of correlated motion. These methods are often observational in that altered motions are achieved by random sampling without revealing the underlying mechanism(s). We present two deterministic methods founded on structure-function relationships that predict dynamic control sites (i.e., locations that experience correlated motions as a result of altered dynamics). The first method ("static") is based on a single structure conformation (e.g., the wild type (WT)) and utilizes a graph description of atomic connectivity. The local atomic interactions are used to compute the propagation of contact paths. This description of structure connectivity reveals flexible locations that are susceptible to altered dynamics. The second method ("dynamic") is a comparative analysis between the normal modes of a WT structure and a mutant structure. A mapping function is defined that quantifies the significance of the motions in one structure projected onto the motions of the other. Each mode is considered up- or down-regulated according to its change in relative significance. This description of altered dynamics is the basis for a motion correlation analysis, from which the dynamic control sites are readily identified. The methods are theoretically derived and applied using the canonical system dihydrofolate reductase (DHFR). Both methods demonstrate a very high predictive value (p<0.005) in identifying known dynamic control sites. The dynamic method also produces a new hypothesis regarding the mechanism by which the DHFR mutant achieves hyperactivity. These tools are suitable for allosteric investigations and may greatly enhance the speed and effectiveness of other computational and experimental methods.
Stimulatory Effect of Progesterone on the Expression of Steroidogenic Acute Regulatory Protein in MA-10 Leydig Cells1 (2003)

The steroidogenic acute regulatory protein (StAR), by virtue of its ability to facilitate the intramitochondrial transport of cholesterol, plays an important role in regulating steroid hormone biosynthesis in steroidogenic cells. In agreement with published data, both StAR expression and progesterone production in MA-10 mouse Leydig tumor cells could be stimulated with hCG and 8Br-cAMP. Addition of aminoglutethimide, an inhibitor of cholesterol side chain cleavage (P450(scc)) enzyme, not only resulted in a drastic inhibition of progesterone production but also in an attenuation of StAR expression in response to either hCG or 8-Br-cAMP. Therefore, we addressed the question of whether progesterone, the end product of the steroidogenic cascade in these cells, could be in a position to regulate the StAR gene expression. In MA-10 cells, we report here that progesterone in microgram amounts can induce StAR gene expression in a time- and dose-dependent manner. StAR expression in response to a maximally effective concentration of progesterone of 10 microg/ml was highest at 6 h and started decreasing thereafter. The effect of progesterone on StAR protein and StAR mRNA induction was mimicked by its synthetic analog, progestin R5020, but not by other steroids, including dexamethasone, estradiol, testosterone, and dihydrotestosterone. Dexamethasone, in contrast, was able to inhibit StAR expression in MA-10 cells. Surprisingly, RU486, a potent antagonist of progesterone and glucocorticoid action, had a stimulatory effect on StAR mRNA levels. Reverse transcription-polymerase chain reaction analysis demonstrated the absence of the classical form of progesterone receptor in MA-10 cells. Thus, for the first time, a direct stimulatory effect of a steroid on StAR gene expression has been demonstrated. Furthermore, these results provide a new insight, indicating that progesterone mediates the activation of StAR expression exerted presumably through a novel, nonclassical progesterone receptor in mouse Leydig cells.
Optimal PWM method for flux reduction in InterCell Transformers coupling double three-phase systems (2012)

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