gebhart/patrepeval huggingface dataset:
Signalübertragung (2018)

No AccessGrundlagen der NachrichtentechnikAug 2018SignalübertragungCarsten RoppelCarsten Roppelhttps://doi.org/10.3139/9783446456952.002SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2018Pages: 19-65Print ISBN: 978-3-446-45324-1eISBN: 978-3-446-45695-2 Copyright & Permissions© 2018 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Population-Wide Evaluation of Disease Manifestation in Relation to Molecular Genotype in Steroid 21-Hydroxylase (CYP21) Deficiency: Good Correlation in a Well Defined Population1 (1997)

We report a population-wide analysis of all patients with 21-hydroxylase deficiency (21-OHD) found in Finland, a country with a genetically well defined population, in which the effects of other genetic and environmental factors on the phenotype can be expected to be low. In total, 120 patients were identified, and their clinical status was evaluated. Blood samples for CYP21 genotype determination could be obtained from 78 (65%) patients, and their phenotypes were compared with their genotypes. In general, the severity of gene defects correlated well with clinical expression. All patients carrying mutations with the most drastic effects on enzymatic activity had the salt-wasting form of 21-OHD. The I2 splice mutation, which in some reports has been connected with clinical variation, was constantly associated with severe mineralocorticoid deficiency. However, patients with I172N as the determining mutation expressed a wide spectrum of phenotypes; the variation could not be attributed to additional mutations. Although genetically affected males with the nonclassical form had not been clinically diagnosed, our study suggests that nonclassical 21-OHD is substantially more rare in Finland than elsewhere, as indicated by both clinical evaluation and mutational screening.
Low‐temperature, solvent‐free dehydration of cineoles with heterogeneous acid catalysts for the production of high‐density biofuels (2014)

Abstract BACKGROUND Oxygenated terpenoids such as 1,4‐cineole and 1,8‐cineole can be major components of turpentine and essential oils. These terpenoids can also be produced from sugars via a biosynthetic approach. Catalytic deoxygenation of these substrates has the potential to efficiently generate commercially important chemicals and high density fuels for turbine or diesel propulsion. RESULTS The low‐temperature deoxygenation reactions of 1,4‐cineole and 1,8‐cineole over the heterogeneous acid catalysts Amberlyst‐15, Nafion SAC ‐13, and Montmorillonite K10 have been studied. 1,4‐cineole was found to isomerize to terpinene‐1‐ol followed by dehydration to a mixture primarily composed of α‐ and γ‐terpinene. In a similar manner, 1,8‐cineole was found to isomerize to α‐terpineol followed by dehydration to primarily terpinolene and α‐terpinene. Amberlyst‐15 was the most active catalyst on a mass basis and gave 100% conversion of 1,4‐cineole in 24 h at 85°C. Longer reaction times or higher reaction temperatures led to significant conversion of the dehydrated monoterpenes to diterpenes. Similar trends were observed for Nafion SAC ‐13 and Montmorillonite K10 . CONCLUSION This work provides important mechanistic information regarding the dehydration chemistry of cineoles and shows the potential of heterogeneous acid catalysts to effectively convert oxygenated terpenoids to high density hydrocarbon mixtures with potential uses as renewable diesel fuels. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
Network flow based BSM asssignment (2009)

in current industry practice, Bottom Surface Metals (BSMs) assignment for high frequency signals on a package device is a tedious manual job. One often needs to change the assignment multiple times in order to produce a routable solution. This paper proposes a network flow based method to assign BSMs automatically. It constructs a network flow graph based on available routing resource, honoring constraints such as wiring/BSM blockages. Then it derives the BSM assignment from the min-cost max-flow solution. The resulting assignment is optimal in terms of routability and wirelength. In practice, some high speed signals require differential pair routing. This paper proposes a two-step BSM assignment algorithm to handle these differential pair constraints. The first step constructs a bi-partite graph which solves the BSM pairing problem automatically. The second step constructs a scaled flow graph to assign BSM pairs to differential pairs. Compared to the manual approach, these methods can provide an optimized solution which also significantly reduces the turn around time of board design process from days to seconds.
Regioselective C–H Activation of Cyclometalated Bis-Tridentate Ruthenium Complexes (2011)

A series of bis-tridentate Ru(II) complexes consisting of trimethyl-4,4′,4″-tricarboxylate-2,2′:6′,2″-terpyridine (Me3tctpy) and derivatized 6-phenyl-2,2′-bipyridine (pbpy) ligands are reported. Each complex is attached to a terminal triphenylamine (TPA) substituent at the central ring of pbpy through a thiophene bridge to benefit light absorption, while the anionic ring of pbpy is functionalized with substituents to modulate the metal-based redox potential. The cyclometalation step was found to favor the isomer where the electron-donating groups (EDGs; i.e., −OEt, −SEt) are situated ortho to the organometallic bond rather than the sterically favored para position, while the para isomer is formed in exclusivity when electron-withdrawing groups (e.g., −CF3) are installed on the anionic ring. Moreover, the distribution of the isomeric products is affected by the identity of the chalcogen: ortho:para = 1:0 and 3:1 where EDG = −OEt and −SEt, respectively. Because our molecular scaffold rules out certain cyclometalation pathways (e.g., oxidative addition, agostic interactions, σ-bond metathesis), we are able to experimentally establish that the observed regioselectivity is in accordance with an electrophilic metalation where the relative stabilities of the products and carbanionic intermediates govern the ratio of the isomers formed.
Transformation Suppression by Protein Tyrosine Phosphatase 1B Requires a Functional SH3 Ligand (1998)

We have recently shown that protein tyrosine phosphatase 1B (PTP1B) associates with the docking protein p130Cas in 3Y1 rat fibroblasts. This interaction is mediated by a proline-rich sequence on PTP1B and the SH3 domain on p130Cas. Expression of wild-type PTP1B (WT-PTP1B), but not a catalytically competent, proline-to-alanine point mutant that cannot bind p130Cas (PA-PTP1B), causes substantial tyrosine dephosphorylation of p130Cas (F. Liu, D. E. Hill, and J. Chernoff, J. Biol. Chem. 271:31290-31295, 1996). Here we demonstrate that WT-, but not PA-PTP1B, inhibits transformation of rat 3Y1 fibroblasts by v-crk, -src, and -ras, but not by v-raf. These effects on transformation correlate with the phosphorylation status of p130Cas and two proteins that are associated with p130Cas, Paxillin and Fak. Expression of WT-PTP1B reduces formation of p130Cas-Crk complexes and inhibits mitogen-activated protein kinase activation by Src and Crk. These data show that transformation suppression by PTP1B requires a functional SH3 ligand and suggest that p130Cas may represent an important physiological target of PTP1B in cells.
Kosten van ziekten in Nederland 2003. Zorg voor euro's- 1 (2006)

In 2003 werd in Nederland 57,5 miljard euro aan de gezondheidszorg uitgegeven, hetgeen overeenkomt met ongeveer 12% van het bruto binnenlands product. Per inwoner ging het om een bedrag van 3.550 euro. Dit rapport beschrijft hoe deze zorgkosten samenhangen met kenmerken van zorggebruikers als ziekte (diagnosegroep), leeftijd en geslacht, het aanbod van zorg (sectoren en zorgfuncties) en de financiering.&lt;br&gt;Van de totale zorgkosten kon 82,5% aan een ziekte worden toegewezen. Psychische stoornissen zijn met 12,7 miljard euro de duurste diagnosegroep. Hierin zijn ook de kosten van verstandelijke handicaps en dementie opgenomen. Op afstand volgen ziekten van het hartvaatstelsel (5,3 miljard euro) en ziekten van het spijsverteringsstelsel (4,6 miljard euro). Symptomen en onvolledig omschreven ziektebeelden (4,2 miljard euro) en aandoeningen van het bewegingsstelsel en bindweefsel (3,9 miljard euro) completeren de top-5.&lt;br&gt;De zorgkosten hangen sterk samen met de leeftijd, en lopen op tot gemiddeld meer dan 40.000 euro per inwoner van Nederland in de hoogste leeftijdsgroepen. Het aandeel van mannen in de totale zorgkosten van 2003 bedroeg 42% en van vrouwen 58%. Het verschil wordt veroorzaakt door de kosten van zwangerschap en geboorte en vooral ook door de hogere levensverwachting van vrouwen.het CBS. Naast dit perspectief zijn nog twee andere invalshoeken volledig uitgewerkt, namelijk het het Budgettair Kader Zorg (BKZ) van het ministerie van VWS en het System of Health Accounts (SHA) van de OECD.&lt;br&gt;
The degree of substitution of hydroxyethyl starch (HES) is a predictor for its in vivo molecular weight (2001)

s and Programme: European Society of Anaesthesiologists; 9th Annual Meeting with the Swedish Society of Anaesthesiology; Gothenburg, Sweden, 7-10 April 2001: Pharmacology
Enhanced betatron X-rays from axially modulated plasma wakefields (2015)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. P. Palastro, D. Kaganovich, D. Gordon; Enhanced betatron X-rays from axially modulated plasma wakefields. Physics of Plasmas 1 June 2015; 22 (6): 063111. https://doi.org/10.1063/1.4923018 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioPhysics of Plasmas Search Advanced Search |Citation Search
Surface Web Balance Method A Neural Network-Based Approach to Mitigate Subsidence in Diatomites coupling Surface Deformation and Injection/Production Data (2016)

Abstract Diatomites are high-porosity, low-permeability reservoirs with elastoplastic properties and high geo-mechanical responsiveness. Despite that, diatomites have great potential for oil recovery. Withdrawal of fluids from the reservoir rock leads to subsidence causing compaction and shear stresses. This disturbed stress distribution results in well failures that causes loss of millions of dollars. Successful maintenance of pressure support through optimum injection/production is key to preventing subsidence to mitigate the risk of well failure and achieve better sweep efficiency for recovery. There have been different approaches to tackle subsidence and well failures in diatomites including the use of ‘backpressure method’ coupled with a neural network to optimize injection-production to ‘balance’ the rock in terms of stress-distribution and thus decrease well failure due to shearing. However, using such methods may mask other problems the well is experiencing, such as, mechanical issues that influence production. Another existing approach, satellite-imaging (InSAR) cannot be used to take real-time actions that is crucial in diatomites. Surface tiltmeter data is collected to undertsand the relationship between injection/production and resulting surface deformation, which also provides information about well-to-well connectivity. A neural network-based approach is followed to determine the nonlinear relationship between surface subsidence/dilation and injection-production. This is then used to build an objective function that works to minimize the differences between well-to-well subsidence/dilation measured by the tiltmeters, by adjusting injection-production for the wells. In this paper, a method that harnesses real-time surface tiltmeter data to adjust injection-production distribution in diatomites to decrease well failures is used beyond the existing applications of surface tiltmeter, such as, in the areas of detection of early steam breach to surface in steam operations and fracture orientation and it provides real-time data for robust reservoir management of such reservoirs where satellite imaging is not effective.
Class V chitin synthase determines pathogenesis in the vascular wilt fungus Fusarium oxysporum and mediates resistance to plant defence compounds (2002)

Chitin, a beta-1,4-linked polysaccharide of N-acetylglucosamine, is a major structural component of fungal cell walls. Fungi have multiple classes of chitin synthases that catalyse N-acetylglucosamine polymerization. Here, we demonstrate the requirement for a class V chitin synthase during host infection by the vascular wilt pathogen Fusarium oxysporum. The chsV gene was identified in an insertional mutagenesis screen for pathogenicity mutants. ChsV has a putative myosin motor and a chitin synthase domain characteristic of class V chitin synthases. The chsV insertional mutant and a gene replacement mutant of F. oxysporum display morphological abnormalities such as hyphal swellings that are indicative of alterations in cell wall structure and can be partially restored by osmotic stabilizer. The mutants are unable to infect and colonize tomato plants or to grow invasively on tomato fruit tissue. They are also hypersensitive to plant antimicrobial defence compounds such as the tomato phytoanticipin alpha-tomatine or H2O2. Reintroduction of a functional chsV copy into the mutant restored the growth phenotype of the wild-type strain. These data suggest that F. oxysporum requires a specific class V chitin synthase for pathogenesis, most probably to protect itself against plant defence mechanisms.
A likelihood ratio test for species membership based on DNA sequence data (2005)

DNA barcoding as an approach for species identification is rapidly increasing in popularity. However, it remains unclear which statistical procedures should accompany the technique to provide a measure of uncertainty. Here we describe a likelihood ratio test which can be used to test if a sampled sequence is a member of an a priori specified species. We investigate the performance of the test using coalescence simulations, as well as using the real data from butterflies and frogs representing two kinds of challenge for DNA barcoding: extremely low and extremely high levels of sequence variability.
Immobilization of a non-heme diiron complex encapsulated in an ammonium-type ionic liquid layer modified on an Au electrode: reactivity of the electrode for O2reduction (2016)

A non-heme diiron complex, possessing dioxygen activation ability, has been encapsulated by an ionic liquid self-assembled mono-layer modified on an Au electrode.
Salicylic acid‐mediated and RNA‐silencing defense mechanisms cooperate in the restriction of systemic spread of plum pox virus in tobacco (2006)

Plum pox virus (PPV) is able to replicate in inoculated leaves of Nicotiana tabacum, but is defective in systemic movement in this host. However, PPV produces a systemic infection in transgenic tobacco expressing the silencing suppressor P1/HC-Pro from tobacco etch virus (TEV). In this work we show that PPV is able to move to upper non-inoculated leaves of tobacco plants expressing bacterial salicylate hydroxylase (NahG) that degrades salicylic acid (SA). Replication and accumulation of PPV is higher in the locally infected leaves of plants deficient in SA or expressing TEV P1/HC-Pro silencing suppressor. Accumulation of viral derived small RNAs was reduced in the NahG transgenic plants, suggesting that SA might act as an enhancer of the RNA-silencing antiviral defense in tobacco. Besides, expression of SA-mediated defense transcripts, such as those of pathogenesis-related (PR) proteins PR-1 and PR-2 or alternative oxidase-1, as well as that of the putative RNA-dependent RNA polymerase NtRDR1, is induced in response to PPV infection, and the expression patterns of these defense transcripts are altered in the TEV P1/HC-Pro transgenic plants. Long-distance movement of PPV is highly enhanced in NahG x P1/HC-Pro double-transgenic plants and systemic symptoms in these plants reveal that the expression of an RNA-silencing suppressor and the lack of SA produce additive but distinct effects. Our results suggest that SA might act as an enhancer of the RNA-silencing antiviral defense in tobacco, and that silencing suppressors, such as P1/HC-Pro, also alter the SA-mediated defense. Both an RNA-silencing and an SA-mediated defense mechanism could act together to limit PPV infection.
The UC san diego health suspicion of cancer clinic. (2023)

e18528 Background: Physicians at UC San Diego Moores Cancer Center (MCC), like at many major cancer centers in the United States, are subspecialized by tumor type. Patients with symptoms concerning for cancer, but without a diagnosis, often face challenges in establishing care with an oncologist, which can potentially lead to delays in diagnosis and treatment. Methods: At our institution, we created a Suspicion of Cancer (SOC) clinic for referral of patients who have symptoms concerning for cancer, but without a definitive diagnosis of malignancy. The purpose of the clinic is to facilitate establishment of a diagnosis and access to an oncologist in a timely manner. We created an order for referral in our electronic medical record system that enables any provider to refer to patients to the SOC clinic. Once a referral is placed, a hematologist-oncologist or medical oncologist reviews the case and approves the patient for an appointment with the SOC clinic. Results: Between January 2022 and November 2022, we received 107 unique referrals to the SOC clinic. The average age of referred patients was 64 years, with 50 (46.7%) females and 57 (53.3%) males. Thirty-four (31.2%) referrals were from primary care doctors, 23 (21.5%) from hospital medicine, 22 (20.6%) from emergency medicine, 15 (14.0%) from medical subspecialties or neurology, 11 (10.3%) from surgery or surgical subspecialties, and 1 (0.93%) that was self-referred. Thirty (28.0%) patients already had definitive diagnosis of malignancy from either our institution or an outside institution, while 77 (72.0%) did not have a diagnosis at time of referral. Of the 107 referrals, 21 (19.6%) did not follow up with a medical oncologist or hematologist-oncologist within our health system. Reasons for not following up included insurance status, establishing care elsewhere, failed attempts to contact patients, or no shows to established clinic appointments. One patient was already established with a hematologist-oncologist within the MCC prior to referral. Eighty-six (80.4%) patients were seen in new consultation by a medical oncologist or hematologist-oncologist at our institution. After referral, the average time to consultation with a medical oncologist or a hematologist-oncologist was 15.3 days. In the 77 cases without diagnosis at time of referral, 39 (50.6%) underwent biopsy, while 38 (49.4%) were deemed to not require biopsy or declined biopsy. Twenty-five (32.5%) patients were diagnosed with cancer and 52 (67.5%) either did not have biopsy or had a negative biopsy. Ninety-two (86.0%) of the 107 referred patients were alive at time of analysis, while 15 (14.0%) were deceased. Conclusions: The MCC SOC clinic offers a referral pathway to expedite diagnosis and access to care for new oncology patients. In continuing to collect data related to the above outcomes, we hope to identify barriers to the delivery of oncologic care and improve patient outcomes.
ENVIRONMENTALLY FRIENDLY ZINC/AQUEOUS POLYSULFIDE RECHARGEABLE FLOW BATTERY WITH HIGH ENERGY EFFICIENCY (2021)

The present invention relates to a zinc/aqueous polysulfide rechargeable flow battery (100) made of&#13;\n- a first half-cell (110) comprising a first electrolyte (114) containing a source of Zn2+ ions and a static (112) or flowable electrode disposed within the first halfcell,&#13;\nsaid first half-cell being connected in a closed-loop configuration through a first pump (116) to a first external tank (115) containing the first electrolyte;&#13;\n- a second half-cell (120) comprising a second electrolyte (124) in which polysulfides are dissolved and a static (122) or flowable electrode disposed&#13;\nwithin the second half-cell, said second half-cell being connected in a closedloop configuration through a second pump (126) to a second external tank&#13;\n 125) containing the second electrolyte; and&#13;\n- a catalyst in the second half-cell, on the surface of a static electrode or dispersed in form of particles in the second electrolyte; and&#13;\n- a separator (130) between the two half-cells.&#13;\nThe rechargeable flow battery of the invention avoids the use of toxic or environmentally harmful chemicals.
Exploring Critical Success Factors for Developing Infrastructure Projects in Malaysia – Main Contractors’ Perspective (2012)

The construction industry needs to develop methodologies and techniques to better promote quality engineering and minimize losses. This study aims to identify the Critical Success Factors (CFSs) that contribute to the successful development of infrastructure projects in Malaysia and examine their possible impact on project objectives in scope, time, cost and quality. Main contractors are usually intensively involved in the development of infrastructure projects. However, there is limited research touching on main contractors’ view on CSFs for infrastructure projects in Malaysia. Therefore, this study is carried out to explore this topic from the main contractors’ perspective. Based on an extensive literature review, 33 candidate CSFs were identified and examined. Practitioners in selected companies that had been intensively involved in infrastructure development in Malaysia were invited to participate in a questionnaire survey. The questionnaire survey was designed to elicit professional opinions of those practitioners on the significance level and the impact on project objectives of the identified candidate CSFs. A significance index (SI) was calculated to show the significance level of the candidate CSFs. This explorative study has found that the majority of the 33 identified candidate CSFs were perceived to be of critical significance by the respondents. Some of them hold particular importance to achieving project management objectives in terms of scope, time, cost, and quality. The findings may be used as a checklist so as to increase the quality and success rate of future infrastructure projects in Malaysia. Research limitations and future directions are also discussed.