gebhart/patrepeval huggingface dataset:
Possible Role of BDNF-Induced Microglial Intracellular Ca<sup>2+</sup> Elevation in the Pathophysiology of Neuropsychiatric Disorders (2011)

Microglia are intrinsic immune cells that release factors, including proinflammatory cytokines, nitric oxide (NO) and neurotrophins, following activation after disturbance in the brain. Elevation of intracellular Ca(2+) concentration ([Ca(2+)]i) is important for microglial functions, such as the release of cytokines and NO from activated microglia. There is increasing evidence suggesting that pathophysiology of neuropsychiatric disorders is related to the inflammatory responses mediated by microglia. Brain-derived neurotrophic factor (BDNF) is a neurotrophin well known for its roles in the activation of microglia as well as in pathophysiology and/or treatment of neuropsychiatric disorders. We have recently reported that BDNF induces a sustained increase in [Ca(2+)]i through binding with the truncated TrkB receptor, resulting in activation of the PLC pathway and store-operated calcium entry (SOCE) in rodent microglial cells. Sustained activation of SOCE, possibly mediated by TRP channels, occurred after brief BDNF application and contributed to the maintenance of sustained [Ca(2+)]i elevation. Pretreatment with BDNF significantly suppressed the release of NO from activated microglia. Additionally, selective serotonin reuptake inhibitors (SSRIs), including paroxetine or sertraline, potentiated the BDNF-induced increase in [Ca(2+)]i in rodent microglial cells This article provides a review of recent findings on the role of BDNF in the pathophysiology of neuropsychiatric disorders, especially by focusing on its effect on intracellular Ca(2+) signaling in microglial cells.
An Eulerian Approach to Computational Fluid Dynamics Simulation of a Chemical-Looping Combustion Reactor With Chemical Reactions (2015)

Chemical-looping combustion (CLC) is a next-generation combustion technology that shows great promise in addressing the need for high-efficiency low-cost carbon capture from fossil fueled power plants. Although there have been a number of experimental studies on CLC in recent years, computational fluid dynamics (CFD) simulations have been limited in the literature. In this paper, simulation of a CLC reactor is conducted using the Eulerian approach in the commercial CFD solver ansys fluent based on a laboratory-scale experiment with a dual fluidized bed CLC reactor. The solid phase consists of a Fe-based oxygen carrier while the gaseous fuel used is syngas. The salient features of the fluidization behavior in the air reactor and fuel reactor beds representing a riser and a bubbling bed, respectively, as well as the down-comer, are accurately captured in the simulation. This work is among the few CFD simulations of a complete circulating dual fluidized bed system for CLC in 3D in the literature. It highlights the importance of 3D simulation of CLC systems and the need for more accurate empirical reaction rate data for future CLC simulations.
Reliable power control for secondary users based on distributed measurements (2011)

An important aspect of spectrum sharing is reliable protection of licensed, primary, users from interference by unlicensed, secondary, users. In this paper we investigate the reliability of the iterative power adjustment algorithm proposed by Pollin, Adams and Bahai (2008). The goal of this transmission power control algorithm is to allow a static secondary transmitter to maximize its power without interfering with primary users. A distributed flooding algorithm is used to detect primary users and estimate the distance to the primary propagation contour. The secondary transmitter makes a local channel estimation with a moving least squares algorithm to average out noise. The metric used to estimate interference is the propagation contour-contour distance between the secondary and primary transmitters. In our first contribution we investigate the reliability of this metric by computing the location probability, a new FCC proposed metric for configuring Digital Terrestrial Television networks. We show that the propagation contour-contour distance is correlated with the location probability. In a second contribution we make the flooding algorithm more cost efficient by reducing communication. We then study the influence of the number of flooding messages on the performance of the iterative power adjustment algorithm in terms of location probability and number of iterations.
Ultrasound-guided soft catheter embryo transfers will improve pregnancy rates in in-vitro fertilization (2000)

Attempts to improve clinical pregnancy rates after in-vitro fertilization (IVF) and embryo transfer are constantly being made. Two changes in technique of embryo transfer of potential clinical importance were evaluated over two contiguous time periods in order to observe any corresponding change in clinical pregnancy (CP) rate per transfer: (i) embryo transfer catheter; (ii) ultrasound guidance. Catheter choices were hard: Tefcat, Tom Cat, or Norfolk; or soft: Frydman or Wallace. Ultrasound visualization was considered to be excellent/good when the catheter could be followed from the cervix to the fundus by transabdominal ultrasound with retention of the embryo-containing fluid droplet; fair/poor if visualization could not document the sequence of events. Embryo transfers were performed in 518 cycles. CP rates per transfer using soft and hard catheters was 36 and 17% (P < 0.000) respectively. CP rates per transfer for transfers performed with and without ultrasound guidance were 38 and 25% (P < 0.002) respectively. A statistically significant difference was also noted when visualization ranks were compared. CP rates per transfer in all excellent/good ultrasound-guided transfers was 41.5 versus 16.7% for fair/poor transfers (P < 0.038). In conclusion, performance of embryo transfer with a soft catheter under ultrasound guidance with good visualization resulted in a significant increase in clinical pregnancy rates.
A simplified dissolution rate apparatus (1969)

Journal Article A simplified dissolution rate apparatus Get access K Marshall, K Marshall Industrial Pharmacy Unit, Postgraduate School of Studies in Pharmacy, University of Bradford, Bradford 7, England Search for other works by this author on: Oxford Academic Google Scholar D B Brook D B Brook Industrial Pharmacy Unit, Postgraduate School of Studies in Pharmacy, University of Bradford, Bradford 7, England Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 21, Issue 11, November 1969, Pages 790–792, https://doi.org/10.1111/j.2042-7158.1969.tb08176.x Published: 12 April 2011 Article history Received: 29 August 1969 Published: 12 April 2011
Poster — Wed Eve—16: Optoacoustic Detection of Tissue Thermal Damage (2009)

Minimally invasive thermal therapy has been investigated as an alternative treatment modality for solid tumours including breast, liver and prostate. Thermal therapy is typically delivered as a single‐fraction, stand‐alone therapy. It involves heating tissues to greater than 55 C over a period of a few minutes, which results in coagulative necrosis. It can potentially achieve highly conformal 3D coagulation volumes, exhibits sharp demarcation between treated and spared tissues, and tissue effects can be observed and thus potentially controlled in real time. This paper describes a new approach to guiding the progress of thermal therapy using optoacoustics, a technique which combines the high optical contrast and high resolution associated with near‐infrared optical imaging and ultrasound imaging, respectively. In this study, thermal lesions were induced in bovine liver ex vivo via non‐contact single fiber laser heating at 810 nm. Optoacoustic signals were obtained using an optoacoustic imaging system comprised of an Nd:YAG pumped Titanium‐Sapphire laser delivering 6 ns pulses and an annular array of 8, 4 MHz transducers. Optoacoustic signal increased up to 2.5 fold with heating times from 1 to 6 minutes. Furthermore, tissue coagulation was clearly visible in the optoacoustic images compared to the surrounding native tissue. The results demonstrate that optoacoustic signals are sensitive to changes in tissue optical and mechanical properties that occur when tissues are thermally damaged, and, hence, optoacoustic imaging may be a suitable candidate for guiding thermal therapy delivery.
Redox-Hopping-Based Charge Transport Mediated by Ru(II)-Polypyridyl Species Immobilized in a Mesoporous Metal-Organic Framework (2022)

Electronic charge transport through crystalline metal-organic frameworks (MOFs) can be accomplished by site-to-site electron (or hole) hopping, provided that redox-active sites, such as easily reducible or oxidizable MOF linkers, are present. If the framework itself is redox-inert, solvent-assisted ligand incorporation of redox-active moieties can serve to enable hopping-based charge transport. Here we have studied the redox hopping process within Ru-bpy@NU-1008, where Ru-bpy is a carboxylate-functionalized derivative, i . e ., a node-ligating derivative, of the well-known chromophore Ru(2,2′-bipyridine) 3 2+ , and NU-1008 is a redox-inert MOF featuring hierarchical porosity and csq topology. Chronoamperometry experiments with electrode-supported thin films of Ru-bpy@NU-1008 show that charge transport is feasible through portions of the MOF, with other portions being inaccessible. Possible confounding features are the undersized c- pores that cross-connect 1D mesoporous channels, as ingress and egress of charge-compensating anions is believed to accompany the net oxidation of Ru(II) to Ru(III) and the reduction of Ru(III) to Ru(II). Phenomenologically, transport through the electroactive portion of the films is diffusion-like, with the magnitude of the apparent diffusion coefficient being 6 × 10 −12 cm 2 /s.
DNN-Based Distributed Multichannel Mask Estimation for Speech Enhancement in Microphone Arrays (2020)

Multichannel processing is widely used for speech enhancement but several limitations appear when trying to deploy these solutions to the real-world. Distributed sensor arrays that consider several devices with a few microphones is a viable alternative that allows for exploiting the multiple devices equipped with microphones that we are using in our everyday life. In this context, we propose to extend the distributed adaptive node-specific signal estimation approach to a neural networks framework. At each node, a local filtering is performed to send one signal to the other nodes where a mask is estimated by a neural network in order to compute a global multi-channel Wiener filter. In an array of two nodes, we show that this additional signal can be efficiently taken into account to predict the masks and leads to better speech enhancement performances than when the mask estimation relies only on the local signals.
Automatisieren von Prüfvorgängen mit bildverarbeitenden Sensoren Teil 1. Technische Randbedingungen beim Einsatz optoelektronischer Sensoren in der Qualitätssicherung / Automated inspection by image processing sensors Part 1. Technical boundary conditions in the use of optoelectronic sensors in quality control (1983)

Article Automatisieren von Prüfvorgängen mit bildverarbeitenden Sensoren Teil 1. Technische Randbedingungen beim Einsatz optoelektronischer Sensoren in der Qualitätssicherung / Automated inspection by image processing sensors Part 1. Technical boundary conditions in the use of optoelectronic sensors in quality control was published on December 1, 1983 in the journal tm - Technisches Messen (volume 50, issue JG).
Invasion of mammalian host cells by Plasmodium sporozoites (2002)

Malaria is transmitted through the bite of an infected mosquito, which introduces Plasmodium sporozoites into the mammalian host. Sporozoites rapidly reach the liver of the host where they are sequestered, a process probably mediated by circumsporozoite (CS) protein. Once in the liver, sporozoites migrate through several hepatocytes by breaching their plasma membranes before infecting a final hepatocyte with formation of a vacuole around the sporozoite, where development occurs into blood stage parasites. We propose that migration through several host cells activates sporozoites for ultimate productive invasion. This migration triggers sporozoite exocytosis, which is necessary for hepatocyte invasion, probably because it provides molecules, such as thrombospondin-related anonymous protein (TRAP), likely required for sporozoite invasion with the formation of a vacuole. How sporozoites migrate from the skin to the liver and invade hepatocytes remains unclear. Understanding this initial stage of malaria is crucial for the development of new approaches against the disease.
Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute myeloid leukemia: implications for Axl as a potential therapeutic target (2013)

Approximately 20% to 25% of patients with acute myeloid leukemia (AML) have a constitutively activated FLT3-internal tandem duplication (FLT3-ITD), and these patients exhibit a poor prognosis. Here, we report that Axl, a receptor tyrosine kinase (RTK) overexpressed and constitutively active in human AML, targets the RTK FLT3 in FLT3-ITD(+) AML. Abrogation of Axl activation by soluble Axl chimeric protein (Axl-Fc) or small interfering RNA (siRNA) diminishes constitutive FLT3 phosphorylation in FLT3-ITD(+) AML. In addition, inhibition of Axl activation by Axl-Fc interferes with the physical interaction between Axl and FLT3. We found that Axl-Fc, a pharmacologic Axl inhibitor, or siRNA targeting Axl inhibits cell growth, induces cell-cycle arrest and apoptosis, and relieves a block in myeloid differentiation of FLT3-ITD(+) AML in vitro. Axl-Fc also suppresses the growth of human FLT3-ITD(+) AML in vivo. Collectively, our data suggest that Axl contributes to the pathogenesis of FLT3-ITD(+) AML through, at least in part, positive regulation of constitutive FLT3 activation. This also suggests that Axl should be pursued as a potential target for the treatment of FLT3-ITD(+) AML.
Number Line Compression and the Illusory Perception of Random Numbers (2010)

Developmental studies indicate that children initially possess a compressed intuition of numerical distances, in which larger numbers are less discriminable than small ones. Education then "linearizes" this responding until by about age eight, children become able to map symbolic numerals onto a linear spatial scale. However, this illusion of compression of symbolic numerals may still exist in a dormant form in human adults and may be observed in appropriate experimental contexts. To investigate this issue, we asked adult participants to rate whether a random sequence of numbers contained too many small numbers or too many large ones. Participants exhibited a large bias, judging as random a geometric series that actually oversampled small numbers, consistent with a compression of large numbers. This illusion resisted training on a number-space mapping task, even though performance was linear on this task. While the illusion was moderately reduced by explicit exposure to linear sequences, responding was still significantly compressed. Thus, the illusion of compression is robust in this task, but linear and compressed responding can be exhibited in the same participants depending on the experimental context.
SU‐GG‐T‐332: Dose to Contralateral Breast: A Comparison of Traditional Linac and Tomotherapy Techniques (2010)

Purpose : To characterize the dose and its distribution to the contralateral breast in patients undergoing whole‐breast radiotherapy using helical tomotherapy, and traditional linac with enhanced dynamic wedges or field‐in‐field techniques. Method and Materials : At the start of this IRB approved study, patients were selected and offered consent and enrollment. Dosimetry was performed using thermoluminescent dosimeters (TLDs) which were individually calibrated and tracked to generate a linear dose response curve for each. Positions for measurement were marked on the patient for reproducibility. The measurement positions were 5 cm superior, inferior, medial, and lateral to the breast center of the contralateral breast and 2 cm from center of sternum toward the contralateral breast. TLDs were placed in buildup caps to ensure buildup to electronic equilibrium. TLDs were placed daily for five consecutive treatments and then read 10 days after the last treatment. Calibration curves were applied to the TLD readings. Results : To date, three patients have been treated on Tomotherapy and five patients with traditional tangents. The contralateral breast doses, presented as a percentage of the prescription dose ± 1 standard deviation, are as follows: Tomotherapy; two cm from sternum 36 ± 8%, five cm medial 17 ± 6%, five cm superior 6 ± 1%, five cm lateral 6 ± 1%, five cm inferior 6 ± 1%. Traditional tangents; two cm from sternum 12 ± 5%, five cm medial 5 ± 2%, five cm superior 2 ± 1%, five cm lateral 2 ± 1%, five cm inferior 2 ± 1%. The average breast dose, calculated as the arithmetic mean of the doses five cm from the breast center, were 9 ± 6% for Tomotherapy and 3 ± 2% for traditional tangents. Conclusion : At our institution, helical tomotherapy produces doses in the contralateral breast that are approximately three times that of traditional tangents.
Review on iron and its importance for human health. (2014)

It is well-known that deficiency or over exposure to various elements has noticeable effects on human health. The effect of an element is determined by several characteristics, including absorption, metabolism, and degree of interaction with physiological processes. Iron is an essential element for almost all living organisms as it participates in a wide variety of metabolic processes, including oxygen transport, deoxyribonucleic acid (DNA) synthesis, and electron transport. However, as iron can form free radicals, its concentration in body tissues must be tightly regulated because in excessive amounts, it can lead to tissue damage. Disorders of iron metabolism are among the most common diseases of humans and encompass a broad spectrum of diseases with diverse clinical manifestations, ranging from anemia to iron overload, and possibly to neurodegenerative diseases. In this review, we discuss the latest progress in studies of iron metabolism and bioavailability, and our current understanding of human iron requirement and consequences and causes of iron deficiency. Finally, we discuss strategies for prevention of iron deficiency.
Optical Doppler Tomography: Imaging in vivo Blood Flow Dynamics Following Pharmacological Intervention and Photodynamic Therapy (1998)

A noninvasive optical technique has been developed for imaging in vivo blood flow dynamics and vessel structure with high spatial resolution. The technique is based on optical Doppler tomography, which combines Doppler velocimetry with optical coherence tomography to measure blood flow velocity at discrete spatial locations in turbid biological tissue. Applications of this technique for monitoring changes in blood flow dynamics and vessel structure following pharmacological intervention and photodynamic therapy are demonstrated.
Implicit functions with guaranteed differential properties (1999)

Theory of R-functions [ 121 provides the methodology for constructing exact implicit functions for any semianalytic set. This paper systematically explores and compares the known constructions in terms of their differential properties and explains how such functions may be constructed automatically from CSG and boundary representations of solids. The constructed functions may be automatically differentiated and integrated and have many important applications in meshfree engineering analysis, motion planning, and scientific visualization.
Cycloaddition of “N‐Acyliminium Ion Pools” with Carbon—Carbon Multiple Bonds. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Predictive Performance Study of Two Digoxin Assays in Subjects With Various Degrees of Renal Function (2000)

This prospective study was conducted to compare the predictive performance of fluorescence polarization immunoassay (FPIA, Abbott TDx Digoxin II) and radioimmunoassay (RIA, Kallestad Labs) with combined low-pressure liquid chromatography/RIA (LPLC/RIA) digoxin assay in measuring 15-17 serum digoxin concentrations (SDC) obtained after a single 10 microg/kg intravenous digoxin dose in patients with various degrees of renal function and at different SDC ranges. Eighteen men and women were stratified into 3 age- and gender-matched groups based upon renal function [N = 6 in each, group I (Cl(cr) < 10 mL/min), group II (Cl(cr) = 10-50 mL/min), and group III (Cl(cr) > 50 mL/min)]. Serum digoxin concentrations were measured at time zero; at 0.25, 0.5, 0.75, 1, 2, 3, 4, 6, 8, and 12 hours; and at 2, 3, 4, and 5-7 days after the digoxin dose, using the three different digoxin assays. TDx Digoxin II was unbiased [mean error -0.09 (95% CI -0.19, 0.01)] and RIA biased [mean error -0.29 (95% CI -0.36, -0.21)] to over-predict SDC by 14.2%. In group I patients, the analysis revealed a bias to over-predict SDC by 6.0% for TDx Digoxin II [mean error -0.16 (95% CI -0.29, -0.07)] and an unbiased performance by RIA. In groups II and III, both TDx Digoxin II and RIA showed biased performance, the mean magnitude of bias was low (< 20%). For intermediate SDC range (> 0.5 ng/mL and < or = 3.0 ng/mL), TDx Digoxin II was unbiased in predicting SDC, whereas RIA was biased to under-predict SDC [mean error 0.13 (95% CI 0.10, 0.16)] by 9.9%. The magnitude of bias observed in all cases was less than 20%. Both assays, TDx Digoxin II and RIA, imprecisely measured SDC for all samples combined, different groups and SDC ranges. In all time-paired samples, TDx Digoxin II (FPIA) performed better than the RIA. In conclusion, the magnitude of bias observed with either assay at different groups and SDC ranges was not likely to be clinically relevant. Therefore, either assay may be used to measure SDC in clinical practice.
A Method for Correcting Bone Induced Artifacts in Computed Tomography Scanners (1978)

A method that corrects for artifacts in X-ray transmission scanners created by the alteration of the energy spectrum by bone is described. The method involves two reconstructions of the pictures: the first establishes the approximate distribution of bone and the second enables the artifacts to be eliminated. The first reconstruction is needed to establish the total amount of bone along each ray. Assuming that the X-ray energy spectrum is known, it is shown how the line integrals can be corrected. The method was tested on several mathematical phantoms as well as on human head data. The nonlinear nature of the spectral artifacts is shown to produce streaks in certain phantoms.
Structural basis of TRPV1 modulation by endogenous bioactive lipids (2023)

TRP ion channels are modulated by phosphoinositide lipids, but the underlying structural mechanisms remain unclear. The capsaicin- and heat-activated receptor, TRPV1, has served as a model for deciphering lipid modulation, which is relevant to understanding how pro-algesic agents enhance channel activity in the setting of inflammatory pain. Identification of a pocket within the TRPV1 transmembrane core has provided initial clues as to how phosphoinositide lipids bind to and regulate the channel. Here we show that this regulatory pocket can accommodate diverse lipid species, including the inflammatory lipid lysophosphatidic acid (LPA), whose actions are determined by their specific modes of binding. Furthermore, we show that an 'empty pocket' channel lacking an endogenous phosphoinositide lipid assumes an agonist-like state, even at low temperature, substantiating the concept that phosphoinositide lipids serve as negative TRPV1 modulators whose ejection from the binding pocket is a critical step towards activation by thermal or chemical stimuli.