gebhart/patrepeval huggingface dataset:
RECOVERY OF FATTY ACID FROM A SOLVATED HYDROCARBON MIXTURE APPLICABLE TO THE BEAVER-HERTER SOLVENT EXTRACTION PROCESS (1987)

Abstract The Herter process is a patented enhanced oil recovery process that proposes the use of a fatty acid as a solvent to recover petroleum from an oil reservoir or a tar sand. The fatty acid solvent is injected into a reservoir formation or mixed with a tar sand in order to reduce the viscosity and increase the mobility of the petroleum. The recovery and recycle of the fatty acid solvent are fundamental parts of the process. The Herter process proposes to recover the fatty acid by saponification, migration of the soap to the aqueous phase, and desaponification of the resulting soap phase. However, the formation of a hydrocarbon-soap-water emulsion severely limits the proposed process. Addition of methanol limits emulsification to allow a meaningful separation to be accomplished. An evaluation of two proposed revisions to the Herter process was made based on batch experiments involving the recovery of oleic acid, linolenic acid, and Georgia Pacific XTOL™304 fatty acid from solvated mixtures with n-heptane. In both of these methods, methanol was introduced to the process as a cosolvent for the saponifying base (sodium hydroxide). The two methods differed in the manner of methanol recovery. In method 1, the saponification heavy phase was distilled to recover methanol. In method 2, the desaponification heavy phase was distilled to recover methanol. Both of these methods had fatty acid recoveries greater than 84%, n-heptane recoveries greater than 89%, and methanol recoveries greater than 67%. Method 1 recovered purer fatty acid and a slightly greater percentage of n-heptane. Method 2 recovered a greater percentage of both fatty acid and methanol. Method 2 was found to be superior when high purity of the recovered fatty acid product was not required.
Lipoprotéines plasmatiques du veau préruminant (1985)

The main lipoprotein classes (HDL, LDL, VLDL, chylomicrons) were isolated from the plasma of four 3-week old preruminant Friesian calves. The proportions of proteins and lipids and the fatty acid composition of the different lipid classes were determined over a 7-hour period corresponding to the pre and post-prandial periods. HDL, LDL, VLDL and chylomicrons averaged 58.3, 19.0, 13.3 and 9.1%, respectively, of total lipoproteins. Triglycerides predominated in VLDL and chylomicrons, and cholesterol esters and phospholipids in HDL and LDL. The lipid proportion and fatty acid composition of a given lipoprotein were stable, except for the triglycerides of the chylomicrons (and VLDL) which were hydrolysed during a 2 to 5-hour period after the morning meal, leading to a higher saturation of the remaining triglycerides. Linoleic acid, abundant in cholesterol esters of HDL (46.5%) and LDL (37.2%) and scarce in the cholesterol esters of VLDL (3.5%) and chylomicrons (3.2%), underlined the dual origin (plasma and tissues) of cholesterol esters in young bovines.
Generation of hypothetical landmarks supporting fast object recognition with autonomous mobile robots (2002)

This paper describes an approach to exploit hypothetical landmarks, based on uncertain, suppositions about objects for feature detection, localization, exploration and object-recognition. Information gained from sensors is combined with additional information obtained from reasoning about the environment. Object recognition based on the generation of plausible completions of explored landmarks and verification by matching in 3D, fairly independent of the robot's behavior, is described. Generated hypothetical landmarks that are missing for suppositions about objects are directly inserted in a dynamic local map of the environment and verified in consecutive sensor-readings. The usage of confirmed and rejected landmarks for the verification of the object hypotheses and for the feature detection and exploration is discussed.
Characteristics and outcomes of frail patients with suspected infection in intensive care units: a descriptive analysis from a multicenter cohort study (2020)

Abstract Background Frailty is associated with morbidity and mortality in patients in intensive care units (ICUs). However, the characteristics of frail patients with suspected infection, including sepsis, remain unclear. We aimed to investigate the characteristics and outcomes of frail patients with suspected infection in ICUs. Methods This is a secondary analysis of a multicenter cohort study conducted by 22 ICUs in Japan. Adult patients (≥ 16 years) with newly suspected infection from December 2017 to May 2018 were included. We compared baseline patient characteristics and outcomes between three frailty groups based on the Clinical Frailty Scale (CFS) score: fit (score 1–3), vulnerable (score 4), and frail (score 5–9). We conducted subgroup analysis of patients with sepsis defined based on Sepsis-3 criteria. We also produced Kaplan–Meier survival curves for 90-day survival. Results We enrolled 650 patients with suspected infection, including 599 (92.2%) patients with sepsis. Patients with a median rating of 3 (3–5) on the CFS were included: 337 (51.8%) were fit, 109 (16.8%) were vulnerable, and 204 were (31.4%) frail. The median age of the patients was 72 years (IQR 60 − 81). The Sequential Organ Failure Assessment scores for fit, vulnerable, and frail patients were 7 (4–10), 8 (5–11), and 7 (5–10), respectively (p = 0.59). The patients' median body temperatures were as follows: fit 37.5 (36.5–38.5)℃; vulnerable 37.5 (36.4–38.6)℃; and frail 37.0 (36.3–38.1)℃ (p &lt; 0.01). C-reactive protein levels of fit, vulnerable, and frail patients were 13.6 (4.6–24.5), 12.1 (3.9–24.9), 10.5 (3.0–21.0) mg/dL, respectively (p &lt; 0.01). In-hospital mortality did not statistically differ according to frailty (p = 0.19). Kaplan–Meier survival curves showed little difference in the mortality rate during the acute phase. However, more vulnerable and frail patients died after the acute phase than fit patients; this difference was not statistically significant (p = 0.25). Compared with fit or vulnerable patients, fewer frail patients were discharged. Conclusion Frail and vulnerable patients with suspected infection, including sepsis, tend to have poor disease outcomes after the acute phase of infection.
Multiple tumoricidal effector mechanisms induced by adriamycin. (1984)

The antitumor cytotoxic mechanisms of Adriamycin-elicited peritoneal exudate cells were investigated. Peritoneal exudate cells from mice collected 1 day after an i.p. injection of Adriamycin (10 mg/kg) displayed enhanced cytotoxicity against P815 (natural killer-insensitive, macrophage-sensitive) but not YAC-1 (natural killer-sensitive) tumor cell lines. These cells contained a sufficient concentration of the drug to be cytotoxic for P815 tumor cells in 18-hr chromium release assays. Freeze-thaw lysates of these peritoneal exudate cells were found to be as cytotoxic to P815 as their corresponding whole cells. The lytic activity of these lysates was removed by centrifugation at 100,000 X g, indicating the insolubility of the effector moiety. These cells were also shown to produce significant amounts of superoxide anion and H2O2 in response to phorbol myristate acetate. A catalase-inhibitable augmentation of the cytotoxicity of these cells against P815 was observed when phorbol myristate acetate was added to the assay. Neutrophils and not macrophages were likely responsible for this effect. Peritoneal lymphocytes from mice given injections of Adriamycin 5 to 7 days previously were cytotoxic to YAC-1 tumor cells in 4-hr assays. Finally, peritoneal macrophages harvested 5 to 7 days after Adriamycin administration were cytotoxic to P815 in the absence of detectable Adriamycin. The addition of phorbol myristate acetate inhibited the lysis of P815 by these cells.
TERNA PARA LA DIRECCION DE LA FACULTAD DE ODONTOLOGIA (1989)

EL DOCTOR JOSE NARRO ROBLES, SECRETARIO GENERAL DE LA UNAM, PRESENTO AL CONSEJO TECNICO DE LA FACULTAD DE ODONTOLOGIA (FO) LA TERNA PARA LA DESIGNACION DEL DIRECTOR DE ESA FACULTAD. EL CONSEJO TECNICO APROBO LA TERNA RESULTADO DEL PASADO PROCESO DE AUSCULTACION, ENTRE LA COMUNIDAD DEL PLANTEL. QUEDO INTEGRADA POR EL DOCTOR FILIBERTO ENRIQUEZ HABIB, EL MAESTRO JOSE OZAWA DEGUCHI Y EL DOCTOR JAVIER PORTILLA ROBERTSON.
Plastic Microgroove Solar Cells Using CuInSe2 Nanocrystals (2016)

Plastic photovoltaic devices (PVs) were fabricated by spray-depositing copper indium diselenide (CuInSe2) nanocrystals into micrometer-scale groove features patterned into polyethylene terephthalate (PET) substrates. Each groove has sidewall coatings of Al/CdS and Au and performs as an individual solar cell. These PV groove features can be linked electrically in series to achieve high voltages. For example, cascades of up to 15 grooves have been made with open-circuit voltages of up to 5.8 V. On the basis of the groove geometry, the power conversion efficiencies (PCEs) of the devices reached as high as 2.2%. Using the active area and photovoltaic response of devices determined from light-beam-induced current (LBIC) and photoreflectivity measurements gave PCE values as high as 4.4%.
Caries risk profile using the Cariogram in governmental and private orthodontic patients at de-bonding (2011)

The "chance to avoid new cavities" in orthodontic patients at de-bonding was less in the governmental group compared with the private group, as illustrated by the Cariogram. The governmental group also had significantly less favorable values than the private group for most of the caries-related factors.
Interaction of mercury and selenium in the larval stage zebrafish vertebrate model (2015)

The compounds of mercury can be more toxic than those of any other non-radioactive heavy element. Despite this, environmental mercury pollution and human exposure to mercury are widespread, and are increasing. While the unusual ability of selenium to cancel the toxicity of mercury compounds has been known for nearly five decades, only recently have some aspects of the molecular mechanisms begun to be understood. We report herein a study of the interaction of mercury and selenium in the larval stage zebrafish, a model vertebrate system, using X-ray fluorescence imaging. Exposure of larval zebrafish to inorganic mercury shows nano-scale structures containing co-localized mercury and selenium. No such co-localization is seen with methylmercury exposure under similar conditions. Micro X-ray absorption spectra support the hypothesis that the co-localized deposits are most likely comprised of highly insoluble mixed chalcogenide HgSxSe(1-x) where x is 0.4-0.9, probably with the cubic zincblende structure.
Improved 2-D regional transit time analysis for optimized scaling of SiGe HBTs (2010)

A new method for two-dimensional (2-D) regional transit time analysis in SiGe HBTs is presented, using a commercially-available TCAD suite with hydrodynamic device simulations. The quasi-static 2-D transit time analysis is first used to determine the cutoff frequency of a well-calibrated 200 GHz SiGe HBT and then applied to the design of hypothetical SiGe HBTs with peak cutoff frequencies of 375 GHz and 450 GHz. These results are benchmarked against full frequency-domain simulations. The new regional analysis is then demonstrated at each scaling node and used to illuminate the 2-D nature of the onset of the Kirk effect and heterojunction barrier effect. These techniques enable the cutoff frequency and transit time components to be determined at lower computational complexity and in greater detail than traditional frequency-domain simulations, and are very useful for optimized scaling.
Treatment of Cockroach Allergen Asthma Model with Imatinib Attenuates Airway Responses (2004)

In the present study it was determined whether a pharmacologic approach to blocking receptor tyrosine kinase-mediated activation during allergic airway responses could be beneficial. To examine these responses, allergic mice were given a single oral dose of imatinib at clinically relevant concentrations, ranging from 0.05 to 50 mg/kg, by oral gavages just before allergen challenge. The reduction in the allergen-induced responses was significant and centered on reducing overall inflammation as well as pulmonary cytokine levels. In particular, the treatment of the mice with imatinib significantly attenuated airway hyperreactivity and peribronchial eosinophil accumulation, and significantly reduced Th2 cytokines, interleukin-4 and interleukin-13. In addition, chemokines previously associated with allergen-induced pulmonary disease, CCL2, CCL5, and CCL6, were significantly reduced in the lungs of the imatinib-treated animals. Together these data demonstrate that the pharmacologic inhibitor imatinib may provide a clinically attractive therapy for allergic, asthmatic responses.
Production of Xylooligosaccharides from Waste Xylan, Obtained from Viscose Fiber Processing, by Selective Hydrolysis Using Concentrated Acetic Acid (2016)

Xylooligosaccharides (XOS) were prepared by selective hydrolysis of the waste xylan, obtained from viscose fiber plants, using concentrated acetic acid. The influences of acetic acid concentration, reaction temperature, and reaction time on the yield and component profiles of XOS product were investigated. These results were further ascertained by designing orthogonal experiments. The hydrolysis of xylan residue was selective, since mainly xylooligosaccharide components were formed, with hardly any impure ingredients, except for a small amount of xylose and traces of furfural, in the hydrolyzed product. Reaction temperature was found to be the most significant factor, influencing the XOS yield. Accurate HPAEC–PAD analysis of component profiles indicated that a maximum XOS yield of 45.86% was achieved on hydrolysis of 33.77 g/L waste xylan using 20% acetic acid for 20 min at 140°C. The main XOS components obtained were xylobiose, xylotriose, and xylotetraose, which were more than xylopentaose and xylohexaose.
Photonic Frequency Double-Mixing Conversion Over the 120-GHz Band Using InP- and Graphene-Based Transistors (2015)

InP-based high electron mobility transistors (InP-HEMTs) and graphene-channel FETs (G-FETs) are experimentally examined as photonic frequency converters for future broadband optical and wireless communication systems. Optoelectronic properties and three-terminal functionalities of the InP-HEMTs and G-FETs are exploited to perform single-chip photonic double-mixing operation over the 120 GHz wireless communication band. A 10 Gbit/s-class data signal on a 112.5 GHz carrier is mixed down to a 25 GHz IF band with an 87.5 GHz LO signal that is simultaneously self-generated from an optically injected photomixed beat note. The results suggest that the intrinsic channel of the G-FET can achieve a speed performance that is superior to that of an InP-HEMT having an equivalent device feature size. The reduction of the extrinsic parasitic resistances and the implementation of an efficient photo-absorption structure in the G-FET may allow a millimeter-wave and sub-THz photonic frequency conversion with a sufficiently high conversion gain for practical purposes.
CE-Storm (2015)

Data Stream Management Systems (DSMS) are crucial for modern high-volume/high-velocity data-driven applications, necessitating a distributed approach to processing them. In addition, data providers often require certain levels of confidentiality for their data, especially in cases of user-generated data, such as those coming out of physical activity/health tracking devices (i.e., our motivating application). This demonstration will showcase Synefo, an infrastructure that enables elastic scaling of DSMS operators, and CryptStream, a framework that provides confidentiality and access controls for data streams while allowing computation on untrusted servers, fused as CE-Storm. We will demonstrate both systems working in tandem and also visualize their behavior over time under different scenarios.
Transcription Factor ZBP-89 Cooperates with Histone Acetyltransferase p300 during Butyrate Activation of p21 Transcription in Human Cells (2000)

Inducible p53-independent regulation of the cyclin-dependent kinase inhibitor p21(waf1) transcription is mediated through proximal GC-rich sites. Prior studies have shown that Sp1, Sp3, and the histone acetylase co-activator p300 are components of the complexes binding to these sites. Although Sp1 and Sp3 collaborate with p300, a direct interaction between Sp1 and p300 does not occur. This study sought to determine whether ZBP-89 rather than Sp1 is the direct target of p300 during butyrate induction of p21(waf1). ZBP-89 (BFCOL1, BERF-1, ZNF 148) is a Krüppel-type zinc finger transcription factor that binds to GC-rich elements and represses or activates known target genes. Adenoviral-mediated expression of ZBP-89 in HT-29 cells revealed that ZBP-89 potentiates butyrate induction of endogenous p21(waf1) gene expression. Further, cotransfection of a ZBP-89 expression vector with a 2.3-kilobase p21(waf1) reporter recapitulated the potentiation by butyrate. DNase I footprinting analysis of the human p21(waf1) promoter with recombinant ZBP-89 identified a binding site at -245 to -215. Electrophoretic mobility shift assays confirmed that both recombinant and endogenous ZBP-89 and Sp1 bind to this element. The potentiation was abolished in the presence of adenoviral protein E1A. Deletion of the N-terminal domain of ZBP-89 abolished the potentiation mediated by butyrate treatment. This same deletion mutant abolished the ZBP-89 interaction with p300. Cotransfection of p300 with ZBP-89 stimulated the p21(waf1) promoter in the absence of butyrate. p300 co-precipitated with ZBP-89 but not with Sp1, whereas ZBP-89 co-precipitated with Sp1. Together, these findings demonstrate that ZBP-89 also plays a critical role in butyrate activation of the p21(waf1) promoter and reveals preferential cooperation of this four-zinc finger transcription factor with p300.
AVrate Voyager: an open source online testing platform (2021)

Subjective testing is an integral part of many research fields considering, e.g., human perception. For this purpose, lab tests are a popular approach to gather ratings for subjective evaluations. However, not in all cases controlled lab tests can be performed, either in cases where no labs are existing, accessible or it may be disallowed to use them. For this reason, online tests, e.g., using crowdsourcing are supposed to be an alternative approach for traditional lab tests. We describe in the following paper a framework to implement such online tests for audio, video, and image-related evaluations or questionnaires. Our framework AVrate Voyager builds upon previously developed frameworks for lab tests including the experience with them. AVrate Voyager uses scalable web technologies to implement a test framework, this ensures that it will be running reliably. In addition, we added strategies for pre-caching to avoid additional influence for play-out, e.g. in the case of video testing. We analyze several conducted tests using the new framework and describe the required steps to modify the provided tool in detail.
Abstract 12810: Data-Driven Clusters of Cardiac Structure and Function and Association With Premature Cardiovascular Disease: The Coronary Artery Disease in Young Adults (CARDIA) Study (2021)

Introduction: Abnormal indices of cardiac structure and function likely cluster together. However, the clinical relevance of data-driven patterns of cardiac remodeling across a broad range of echocardiographic measures, particularly in mid-life, is not known. Hypothesis: Latent class analysis (LCA) will identify distinct clusters of cardiac structure and function based on echocardiographic indices in middle-aged adults that differ in risk of CVD. Methods: We included all CARDIA participants without CVD who underwent an echocardiogram. Continuous parameters were indexed to participant height (if appropriate), imputed with the SVDImpute algorithm (if missing), and filtered to remove pairwise correlations &gt;0.6. We applied LCA using a total of 31 echocardiographic indices (standardized to mean 0 and standard deviation 1) to identify distinct groups based on model convergence, the Bayesian Information Criterion, and class membership &gt;5%. We examined the association between groups and risk of premature CVD (coronary artery disease, stroke, or heart failure) with Cox regression adjusted for traditional risk factors. Results: Of 3,361 participants, mean (SD) age was 50.1 (3.6) years, 57% were female, and 46% were non-Hispanic Black. LCA identified 3 groups: (1) optimal cardiac mechanics; (2) impaired systolic function; and (3) impaired diastolic function ( FIGURE ). Over a median 8.9 years of follow-up, risk of CVD was higher in the impaired diastolic function group (unadjusted hazard ratio [HR] 4.08 [95% CI: 2.48, 6.71] and adjusted HR 1.95 [1.12, 3.40]) compared with the optimal group. The impaired systolic function group had a higher unadjusted risk of CVD (1.86 [1.10, 3.15], which attenuated after adjustment (1.36 [0.79, 2.36]). Conclusions: Unbiased, model-based clustering of cardiac structure and function in middle-aged adults identified distinct patterns of cardiac remodeling that were associated with risk of future CVD.
Process characterization in industrial vessels by flow-following sensor particles (2022)

Abstract Instrumented flow-following sensor particles have been developed for investigation of hydrodynamic and biochemical processes in chemical reactors and bioreactors, where standard measurement techniques are not applicable. The sensor particles allow autonomous long-term measurement of spatially distributed process parameters in the chemically and mechanically harsh environments of e.g. agitated industrial vessels. Each sensor particle comprises of an on-board measurement electronics that logs the signals of the embedded sensors. A buoyancy control unit enables automated taring to achieve neutral buoyancy of the sensor particles. Moreover, controlled floating of the sensor particles is possible to expose them for recovery from the liquid surface. Macro-flow tracking of the sensor particles is validated with circulation time reference measurements by means of salt tracer experiments in a stirred model reactor and computational fluid dynamics (CFD) simulations. Moreover, process characterization with sensor particles is demonstrated in three further applications, namely a biogas pilot digester, an air–water column and a biological wastewater treatment basin. Acquired data were used to fit mixing model parameters, namely effective circulation time, circulation number, degree of suspension and Péclet number.
Kinetic model for lamellipodal actin-integrin 'clutch' dynamics (2008)

In migrating cells, with especial prominence in lamellipodial protrusions at the cell front, highly dynamic connections are formed between the actin cytoskeleton and the extracellular matrix through linkages of integrin adhesion receptors to actin filaments via complexes of cytosolic "connector" proteins. Myosin-mediated contractile forces strongly influence the dynamic behavior of these adhesion complexes, apparently in two counter-acting ways: negatively as the cell-generated forces enhance complex dissociation, and at the same time positively as force-induced signaling can lead to strengthening of the linkage complexes. The net balance arising from this dynamic interplay is challenging to ascertain a priori, rendering experimental studies difficult to interpret and molecular manipulations of cell and/or environment difficult to predict. We have constructed a kinetics-based model governing the dynamic behavior of this system. We obtained ranges of parameter value sets yielding behavior consistent with that observed experimentally for 3T3 cells and for CHO cells, respectively. Model simulations are able to produce results for the effects of paxillin mutations on the turnover rate of actin/integrin linkages in CHO cells, which are consistent with recent literature reports. Overall, although this current model is quite simple it provides a useful foundation for more detailed models extending upon it.