gebhart/patrepeval huggingface dataset:
INA-RESPOND: a multi-centre clinical research network in Indonesia (2015)

Nationally representative observational and translational research is needed to address the public health challenges in Indonesia due to the geographic disparity, recently decentralized health system, and diverse infectious disease priorities. To accomplish this, the Indonesian Ministry of Health in collaboration with the US National Institute of Health has established INA-RESPOND (Indonesia Research Partnership on Infectious Disease) - a clinical research network comprising 9 referral hospitals, 7 medical faculties, and 2 research centres across Indonesia. The network provides a forum to conduct research at a national scale and to address scientific questions that would be difficult to address in smaller research settings. Further, it is currently conducting multi-centre research on the etiologies of fever, sepsis, and tuberculosis. There are opportunities to leverage existing network resources for other public health research needs. INA-RESPOND is an Indonesian-led network in a country with diverse population groups and public health needs which is poised to collaborate with researchers, universities, donors, and industry worldwide. This paper describes the network and its goals and values, as well as the management structure, process for collaboration, and future vision.
Voacanga africana: Chemistry, Quality and Pharmacological Activity (2009)

This review examines the natural products in Voacanga africana, a small tree, whose seeds are the most economically important plant part though in traditional medicines the bark and root are also widely used. Voacanga is used to treat or cure a wide range of diseases in Africa. This paper also discusses the botany, chemistry and pharmacological properties and presents current and potential applications of this species. The alkaloids are the principal bioactive compounds responsible for its use in traditional medicine. The major alkaloids include voacamine, voacangine, vobasine, and ibogaime. Others include voacristine, voacamidine, voacarine, voaphylline, vobtusine, voalfolidine and tabersonine. With over 1,600 tons of seeds exported annually from Ghana and Cote D’Ivoire, voacanga is an important source of additional income for harvesters and exporters in West Africa.
Fiche Objet à biseau distal unifacial ou bifacial simple sur os ou bois d'élan, dit aussi “lame de hache ou d'herminette" (1998)

National audience
Treatment of Gingival Recession Defects with Pouch and Tunnel Technique Using Connective Tissue Graft and Lyophilized Chorion Membrane in Smokers (2023)

BACKGROUND The chorion membrane has been used for several decades as an allograft in tissue repair and various periodontal regenerative procedures. The present study, conducted at a single center in India, aimed to evaluate and compare the clinical outcomes of 26 gingival recession sites in chronic smokers treated using a pouch and tunnel technique with connective tissue graft (CTG) and lyophilized chorion membrane (LCM). MATERIAL AND METHODS The study included 22 smokers with 26 sites of recession defect, with Miller's class I and class II gingival recession, which were allotted into control and test groups. The control group (13 sites) was treated with CTG, and the test group (13 sites) was treated with LCM. Clinical parameters like recession depth, recession width, relative clinical attachment level (RCAL), relative gingival position, width of attached gingiva, and width of keratinized gingiva were recorded at baseline and 6 months postoperatively. Visual analogue scores for pain and wound-healing index scores were assessed in the first week after surgery. RESULTS All clinical parameters showed significant improvements from baseline to 6 months postoperatively in the control and test groups. Recession width, RCAL, width of attached gingiva, and width of keratinized gingiva demonstrated significant differences, whereas mean root coverage percentage and recession depth did not show any significant differences between the study groups at 6 months postoperatively. CONCLUSIONS This study supports the role of LCM allograft as a scaffold to promote soft tissue regeneration and has demonstrated a favorable role for its use in root coverage procedures in patients who smoke.
Exploring the GDB-13 chemical space using deep generative models (2019)

Recent applications of recurrent neural networks (RNN) enable training models that sample the chemical space. In this study we train RNN with molecular string representations (SMILES) with a subset of the enumerated database GDB-13 (975 million molecules). We show that a model trained with 1 million structures (0.1% of the database) reproduces 68.9% of the entire database after training, when sampling 2 billion molecules. We also developed a method to assess the quality of the training process using negative log-likelihood plots. Furthermore, we use a mathematical model based on the "coupon collector problem" that compares the trained model to an upper bound and thus we are able to quantify how much it has learned. We also suggest that this method can be used as a tool to benchmark the learning capabilities of any molecular generative model architecture. Additionally, an analysis of the generated chemical space was performed, which shows that, mostly due to the syntax of SMILES, complex molecules with many rings and heteroatoms are more difficult to sample.
Modeling and Simulation of Saturated Geomaterials (2007)

Fully coupled, porous solid-fluid formulation and related modeling and simulation issues are presented in this work. In particular, coupled dynamic field equations with u – p – U formulation are used to simulate pore fluid and soil skeleton responses. Present formulation allows, among other features, for water accelerations to be taken into account. This proves useful in modeling dynamic interaction of media of different stiffness (as in soil-foundation-structure interaction). Fluid compressibility is also explicitly taken into account, thus allowing excursions into modeling of limited cases of non-saturated porous media. One of the main challenges in modeling saturated soils is the appropriate modeling of elastic-plastic behavior of soil skeleton. This challenge is met with the use of an advanced material model and is discussed at some length. Illustrative examples describing dynamical behavior of porous media (saturated soils) are presented. Of particular interest is the verification and validation (V&V) of current models and simulations, and examples will be used for that purpose.
Electronic Structure and Reactivity of Low-Spin Fe(III)−Hydroperoxo Complexes:  Comparison to Activated Bleomycin (2002)

The spectroscopic properties, electronic structure, and reactivity of the low-spin Fe(III)-hydroperoxo complex [Fe(N4Py)(OOH)](2+) (1, N4Py = N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine) are investigated in comparison to those of activated bleomycin (ABLM). Complex 1 is characterized by Raman features at 632 (Fe-O stretch) and 790 cm(-1) (O-O stretch), corresponding to a strong Fe-O bond (force constant 3.62 mdyn/A) and a weak O-O bond (3.05 mdyn/A). The UV-vis spectrum of 1 shows a broad absorption band around 550 nm that is assigned to a charge-transfer transition from the hydroperoxo to a t(2g) d orbital of Fe(III) using resonance Raman and MCD spectroscopies and density functional (DFT) calculations. Compared to low-spin [Fe(TPA)(OH(x))(OO(t)Bu)](x+)(TPA = tris(2-pyridylmethyl)amine, x = 1 or 2), an overall similar Fe-OOR bonding results for low-spin Fe(III)-alkylperoxo and -hydroperoxo species. Correspondingly, both systems show similar reactivities and undergo homolytic cleavage of the O-O bond. From the DFT calculations, this reaction is more endothermic for 1 due to the reduced stabilization of the .OH radical compared to .O(t)Bu and the absence of the hydroxo ligand that helps to stabilize the resulting Fe(IV)=O species. In contrast, ABLM has a somewhat different electronic structure where no pi donor bond between the hydroperoxo ligand and iron(III) is present [Neese, F.; Zaleski, J. M.; Loeb-Zaleski, K.; Solomon, E. I. J. Am. Chem. Soc. 2000, 122, 11703]. Possible reaction pathways for ABLM are discussed in relation to known experimental results.
Attribute-Based Prediction of File Properties (HCS-TR-14-03) (2018)

We present evidence that attributes that are known to the file system when a file is created, such as its name, permission mode, and owner, are often strongly related to future properties of the file such as its ultimate size, lifespan, and access pattern. More importantly, we show that we can exploit these relationships to automatically generate predictive models for these properties, and that these predictions are sufficiently accurate to enable optimizations.
Estimation of Systematic and Spatially Correlated Components of Random Signals from Repeated Measurements: Application to Contrast Enhanced Computer Tomography Measurements (2016)

Observational errors can be categorized into two groups: random noise, which is altered every time when measurement is repeated, and a systematic temporally invariant error. In this paper, we propose a method to estimate the covariance structure for systematic error and random noise using a small number of repeated measurements of the signal. We model the systematic and random components as stationary Gaussian random fields and use the Bayesian approach to estimate the spatial covariance functions of these components simultaneously. The study is motivated by an application related to the diagnosis of joint diseases using contrast enhanced computer tomography (CT) measurements. The noise in the measured contrast agent concentration profiles within cartilage tissue is strongly spatially correlated and includes a systematic component. Since the estimates are significantly sensitive to all errors in modeling, the systematic error and random noise components should be characterized for reliable estimation. The method proposed in this paper can be used to construct approximative covariance matrices for the observational noise using a small number of CT measurements. The capabilities of the proposed method are demonstrated using numerical simulations and also real CT data corresponding to measurements of contrast agent diffusion profile in cartilage.
Quantitative proton magnetic resonance of plasma from uraemic patients during dialysis (1987)

Abstract Proton nuclear magnetic resonance ( 1 H NMR) has been used to measure rapidly concentrations of metabolites in plasma from patients with chronic renal failure (CRF) and normal subjects. Detailed quantitative analyses of spectra are presented for four CRF patients during haemodialysis, two patients in early stages of renal failure and two normal subjects. For patients on acetate dialysis, the method clearly shows how well exogenous acetate is metabolized during and after dialysis. Our results indicate a discrepancy between creatinine concentrations measured by 1 H NMR and by the kinetic Jaffé reaction method, and also point to high betaine concentrations in plasma from some patients on maintenance haemodialysis and taking folate supplement.
shape - A Software Configuration Management Tool. (1988)

This paper describes the design of a configuration management toolkit, which integrates a dedicated version control system and shape, a significantly enhanced Make [7] program. Enhancements include full access to the version control system and support of configuration rules which control the selection process for component versions during identification, build or rebuild of system configurations. Since integration of version control was a major objective for our system, we had to face the need for a document identification scheme that goes beyond the usual way of specifying name and type of a document. As a consequence, we began to design an attributed filesystem (AFS) that introduces a much more generalized scheme for document identification. The AFS comprises concepts for version control, support for variants or status models for example. Furthermore, it helps to abstract from the particular underlying data storage system in such a way that it makes no difference whether it is an or...
Detecting Cascades from Weak Signatures (2017)

Inspired by cyber-security applications, we consider the problem of detecting an infection process in a network when the indication that any particular node is infected is extremely noisy. Instead of waiting for a single node to provide sufficient evidence that it is indeed infected, we take advantage of the graph structure to detect cascades of weak indications of failures. We view the detection problem as a hypothesis testing problem, devise a new inference algorithm, and analyze its false positive and false negative errors in the high noise regime. Extensive simulations show that our algorithm is able to obtain low errors in the high noise regime by taking advantage of cascading topology analysis.
Mapping Sodium Jump Dynamic Distributions in NASICON Materials Using High Temperature 23Na NMR Spectroscopy Relaxation Measurements. (2015)

Abstract not provided.
STRUCTURAL AND FUNCTIONAL STUDIES OF UDP-GLUCURONOSYLTRANSFERASES* (1999)

UDP-Glucuronosyltransferases (UGTs) are glycoproteins localized in the endoplasmic reticulum (ER) which catalyze the conjugation of a broad variety of lipophilic aglycon substrates with glucuronic acid using UDP-glucuronic acid (UDP-GIcUA) as the sugar donor. Glucuronidation is a major factor in the elimination of lipophilic compounds from the body. In this review, current information on the substrate specificities of UGT1A and 2B family isoforms is discussed. Recent findings with regard to UGT structure and topology are presented, including a dynamic topological model of UGTs in the ER. Evidence from experiments on UGT interactions with inhibitors directed at specific amino acids, photoaffinity labeling, and analysis of amino acid alignments suggest that UDP-GIcUA interacts with residues in both the N- and C-terminal domains, whereas aglycon binding sites are localized in the N-terminal domain. The amino acids identified so far as crucial for substrate binding and catalysis are arginine, lysine, histidine, proline, and residues containing carboxylic acid. Site-directed mutagenesis experiments are critical for unambiguous identification of the active-site architecture.
Synthesis and Characterization of Poly(NIPAM-co-AA) Polymers Possessing Perfluorinated Side Chains and Chemically Linked Pyrene Labels (2012)

The synthesis of Poly(n-isopropylacrylamide–co-acrylic acid)/-Poly(NIPAM-co-AA) polymers featuring perfluorinated side chains as well as chemically linked pyrene fluorescence labels has been reported. The resulting polymers have been characterized with the aid of UV/VIS, FTIR spectroscopy and Gel permeation chromatography.DOI: http://dx.doi.org/10.3126/jncs.v27i1.6663 J. Nepal Chem. Soc., Vol. 27, 2011 67-73
Facial retargeting using neural networks (2014)

Mapping the motion of an actor's face to a virtual model is a difficult but important problem, especially as fully animated characters are becoming more common in games and movies. Many methods have been proposed but most require the source and target to be structurally similar. Optical motion capture markers and blendshape weights are an example of topologically incongruous source and target examples that do not have a simple mapping between one another. In this paper, we created a system capable of determining this mapping through supervised learning of a small training dataset. Radial Basis Function Networks (RBFNs) have been used for retargeting markers to blendshape weights before but to our knowledge Multi-Layer Perceptron Artificial Neural Networks (referred to as ANNs) have not been employed in this way. We hypothesized that ANNs would result in a superior retargeting solution compared to the RBFN, due to their theoretically greater representational power. We implemented a retargeting system using ANNs and RBFNs for comparison. Our results found that both systems produced similar results (figure 1) and in some cases the ANN proved to be more expressive although the ANN was more difficult to work with.
When agents roam, who can you trust? (2002)

Roaming agents threaten a server with theft of assets, system resources and reputation. Generally ignored is the reciprocal threat of server against agent. Not only might a server steal the assets, resources, and reputation of an agent, but it might actually kill the agent. The central security concern for systems that allow agents to roam is how to establish trust, and how to limit risk for both the server and the agent. The travels of the agent are key to establishing trust, and trust determines the level of risk.
Packaging Solution for RF SiP with on-top Integrated Antenna (2021)

Silicon based semiconductors are becoming a source of innovation in the field of RF solutions, especially involved in devices used in our everyday life. Wi-Fi and Bluetooth® connections adopted in home-networking, consumer platforms and wearable devices, together with the large spread of the IoT solutions, are more and more requiring very high levels in system integration. In particular, the focus on single-package Blue Tooth Low Energy (BTLE) system is increasing in the last few years. In this scenario, an innovative SiP (System in Package) solution with antenna integration on the top is considered as a possible and reliable alternative to SMD (Surface Mounted Device) antenna assembled on the package substrate. This paper will present a complex SiP composed by multiple stacked organic substrates, integrating a meander antenna that works in the Bluetooth® bandwidth. After describing the structure, the design methodology and the assembly strategy, a particular focus will be put on the antenna integration and dimensioning, supported by full-wave 3D electromagnetic simulations. The influence of the surrounding system on the antenna performance, and consequently the importance of co-design and co-simulation, will be emphasized.
148 Use of an Alpha-Linolenic Acid Source to Reduce Omega-6:3 Ratio in Prrs-Virus Challenged Nursery Pigs (2022)

Abstract A total of 1,056 pigs [PIC TR4 × (Fast LW × PIC L02)], originating from an active PRRSV-positive sow farm, were used in a 46-d study to evaluate growth performance and mortality and removals of nursery pigs. Pigs were fed diets containing increasing levels of O3 Trial Feed (NBO3, Manhattan KS), a source of omega-3 fatty acids (alpha-linolenic acid). At placement in the nursery, pens of pigs were randomly assigned 1 of 4 dietary treatments in a completely randomized design with 22 pigs per pen and 12 replications per treatment. The dietary treatments included increasing percentages of O3 Trial Feed (0, 0.75, 1.5, and 3%). Omega-6:3 ratios for the 4 treatments within each phase were: Phase 1 (15.1:1, 8.4:1, 5.9:1, 3.7:1); Phase 2 (16.5:1, 9.2:1, 6.4:1, 4.0:1); Phase 3 (20.8:1, 10.4:1, 7.0:1, 4.2:1); and Phase 4 (25.3:1, 12.5:1, 8.3:1, 5.0:1), respectively. Pigs remained on treatments throughout the 4 dietary phases over the 46-d study. Overall, pigs fed increased O3 Trial Feed had increased (linear, P &amp;lt; 0.001) ADG, ADFI and G:F. The greatest impact on growth due to dietary treatment began when pigs tested positive for PRRSV during week 3 of the study. This was confirmed by testing oral fluids, collected on a weekly basis, for PRRSV using a PCR test. Pigs fed increasing O3 Trial Feed also had decreased (linear, P = 0.027) total removals and mortalities. In summary, adding O3 Trial Feed to reduce the Omega 6-3 ratio improved growth performance and reduced mortality in nursery pigs with an active PRRSV challenge.
On double magicity of the 6828Ni40 nucleus (2007)

Single-particle energies E nlj of neutron states in the 28 68 Ni40 nucleus are estimated on the basis of extrapolation of the experimental values of E nlj in the 58,60,62,64Ni isotopes. The data obtained are compared with the results of calculation within the dispersion optical model.
Can low accuracy disease risk predictor models improve health care using decision support systems? (1998)

A prototype decision support system has been designed for managing dental caries using a risk assessment model. Caries is a multifactorial disease with risk prediction models having low sensitivity (65%) and moderate specificity (80%) for 2 or more new lesions. These models are inaccurate for targeting resources at high risk people. However, low risk individuals can be more accurately identified. If the activity of early tooth decay lesions, in low risk people, are monitored over time and only lesions beyond 1/3 of the dentin depth are filled, the number of annual fillings may be reduced by 50%. Currently, most US dental schools do not teach risk assessment for caries and encourage early treatment of lesions leading to a repair destruction cycle. The combination of a decision support system with a moderate accuracy specificity risk model for predicting low risk individuals may produce a significant improvement in caries management.
Cirsoid Aneurysm after Hysterectomy (2001)

Cirsoid aneurysm, an uncommon abnormal either congenital or acquired arteriovenous communication, is described. As massive life-threatening bleeding can be a consequence, diagnosis is very important. Earlier, angiography was the only imaging method available for visualizing vascular lesions and recent developments in imaging techniques have made diagnostic imaging of cirsoid aneurysms possible using ultrasonography, color flow mapping, magnetic resonance imaging and magnetic resonance angiography. In this report, a patient with intrapelvic cirsoid aneurysm posthysterectomy who died 8 h after she had been kicked in the abdomen is described and the results obtained by various imaging techniques are discussed.
Synthesis, Electronic Structure, and Reactivity of Strained Nickel-, Palladium-, and Platinum-Bridged [1]Ferrocenophanes (2010)

The group 10 bis(phosphine)metalla[1]ferrocenophanes, [{Fe(η(5)-C(5)H(4))(2)}M(Pn-Bu(3))(2)] [M = Ni (4a), Pd (4b), and Pt (4c)], have been prepared by the reaction of Li(2)[Fe(η(5)-C(5)H(4))(2)]·tmeda (5, tmeda = N,N,N',N'-tetramethylethylenediamine) with trans-[MCl(2)(Pn-Bu(3))(2)] [M = Ni (trans-6a) and Pd (trans-6b)] and cis-[PtCl(2)(Pn-Bu(3))(2)] (cis-6c), respectively. Single crystal X-ray diffraction revealed highly tilted, strained structures as characterized by α angles of 28.4° (4a), 24.5° (4b), and 25.2° (4c) and a distorted square planar environment for the group 10 metal center. UV/visible spectroscopy and cyclic voltammetry indicated that all three compounds had smaller HOMO-LUMO gaps and were more electron-rich in nature than ferrocene and other comparable [1]ferrocenophanes. DFT calculations suggested that these differences were principally due to the electron-releasing nature of the M(Pn-Bu(3))(2) metal-ligand fragments. Attempts to induce thermal or anionic ring-opening polymerization of 4a-c were unsuccessful and were complicated by, for example, competing ligand dissociation processes or unfavorable chain propagation. In contrast, these species all reacted rapidly with acids effecting clean extrusion of the bis(phosphine)metal fragment. Carbon monoxide inserted cleanly into one of the palladium-carbon bonds of 4b to afford the ring-expanded, acylated product [{Fe(η(5)-C(5)H(4))(η(5)-C(5)H(4))(CO)}Pd(Pn-Bu(3))(2)] (10). The nickel analogue 4a, however, afforded [Ni(CO)(2)(Pn-Bu(3))(2)] whereas the platinum-bridged complex 4c was inert. Remarkably, all compounds 4a-c were readily oxidized by elemental sulfur to afford the [5,5']bicyclopentadienylidene (pentafulvalene) complexes [{η(4):η(0)-C(5)H(4)(C(5)H(4))}M(Pn-Bu(3))(2)] [M = Ni (11a)] and [(η(2)-C(10)H(8))M(Pn-Bu(3))(2)] [M = Pd (11b) and Pt (11c)] by a formal 4-electron oxidation of the carbocyclic ligands. Compounds 11b and 11c represent the first examples of [5,5']bicyclopentadienylidene as a neutral η(2)-ligand. The relative energies of η(2)-coordination with respect to that of η(4):η(0) bonding were investigated for 11a-c by DFT calculations.