gebhart/patrepeval huggingface dataset:
Late Breaking Abstract - Small Airways Dysfunction (SAD) correlates with relevant asthma outcomes: longitudinal results from the AssessmenT of smalL Airways involvemeNT In aSthma (ATLANTIS) Study (2020)

<b>Introduction:</b> While SAD is a feature of asthma, the association of SAD with relevant asthma outcomes deserves further investigation. The ATLANTIS study was designed to identify which combination of physiologic variables best measures the presence and extent of SAD in asthma cross-sectionally and during 1-year follow-up. We created a SAD score as a data-driven combination of many physiologic variables measured and found evidence of SAD in 91% of our asthma population. In the 1-year follow up, we determined which of the physiologic tests associated most strongly with exacerbations. <b>Methods:</b> 773 participants with mild, moderate and severe stable asthma were followed for one year with six-month clinic and three-month telephone follow-ups. Physiologic tests included: spirometry, body plethysmography, impulse oscillometry (IOS), and multiple breath nitrogen washout. We examined associations between physiologic measurements and asthma exacerbations over one year using correlations and Poisson regression. <b>Results:</b> The mean number of exacerbations per patient per year in the longitudinal phase was 0.32. Exacerbations over one year were significantly associated with RV/TLC (r=0.20, p&lt;0.0001) and R5-R20 (r=0.22, p&lt;0.0001). <b>Conclusion:</b> These results suggest SAD as measured by RV/TLC and R5-R20, two accessible tests of small airways function, contributes longitudinally to important clinical outomes in asthma.
Correlations between Wetting and Structure in Methylsiloxane Layers on Oxides Formed by Chemical Vapor Surface Modification (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrelations between Wetting and Structure in Methylsiloxane Layers on Oxides Formed by Chemical Vapor Surface ModificationHiroaki Tada, Koichiro Nakamura, and Hirotsugu NagayamaCite this: J. Phys. Chem. 1994, 98, 47, 12452–12457Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://doi.org/10.1021/j100098a048RIGHTS & PERMISSIONSArticle Views122Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts
One-Step Formation of W/O/W Multiple Emulsions Stabilized by Single Amphiphilic Block Copolymers (2012)

Multiple emulsions are complex polydispersed systems in which both oil-in-water (O/W) and water-in-oil (W/O) emulsion exists simultaneously. They are often prepared accroding to a two-step process and commonly stabilized using a combination of hydrophilic and hydrophobic surfactants. Recently, some reports have shown that multiple emulsions can also be produced through one-step method with simultaneous occurrence of catastrophic and transitional phase inversions. However, these reported multiple emulsions need surfactant blends and are usually described as transitory or temporary systems. Herein, we report a one-step phase inversion process to produce water-in-oil-in-water (W/O/W) multiple emulsions stabilized solely by a synthetic diblock copolymer. Unlike the use of small molecule surfactant combinations, block copolymer stabilized multiple emulsions are remarkably stable and show the ability to separately encapsulate both polar and nonpolar cargos. The importance of the conformation of the copolymer surfactant at the interfaces with regards to the stability of the multiple emulsions using the one-step method is discussed.
Integration of desalinated seawater into a distribution system: A corrosion pilot study (2008)

A proposed seawater desalination plant for Carlsbad, Calif., will produce treated water that varies from the city—s typical imported surface water supply. A six‐month pilot study was conducted to compare how Carlsbad distribution materials would be affected by the potential corrosion that might arise from conditioned desalinated seawater versus the city—s typical supply. Various distribution and home plumbing appurtenances were evaluated in parallel test systems, including copper pipe, brass service meters, cement‐mortar‐lined pipe, and cast‐iron distribution system gate valves. Corrosion was assessed by analyzing changes in water quality caused by pipe corrosion or passivation, including metal concentration (iron, zinc, lead, copper, and aluminum), calcium, alkalinity, and turbidity changes. Pilot testing demonstrated that conditioned reverse osmosis permeate achieving minimum water quality goals—alkalinity of 45 mg/L as calcium carbonate (CaCO 3 ), hardness of 40 mg/L as CaCO 3 , and pH of 8.5—was not likely to trigger new corrosion problems in the Carlsbad distribution system.
α7‐Nicotinic acetylcholine receptors mediate an Aβ1−42‐induced increase in the level of acetylcholinesterase in primary cortical neurones (2004)

The beta-amyloid protein (Abeta) is the major protein component of amyloid plaques found in the Alzheimer brain. Although there is a loss of acetylcholinesterase (AChE) from both cholinergic and non-cholinergic neurones in the brain of Alzheimer patients, the level of AChE is increased around amyloid plaques. Previous studies using P19 cells in culture and transgenic mice which overexpress human Abeta have suggested that this increase may be due to a direct action of Abeta on AChE expression in cells adjacent to amyloid plaques. The aim of the present study was to examine the mechanism by which Abeta increases levels of AChE in primary cortical neurones. Abeta1-42 was more potent than Abeta1-40 in its ability to increase AChE in primary cortical neurones. The increase in AChE was unrelated to the toxic effects of the Abeta peptides. The effect of Abeta1-42 on AChE was blocked by inhibitors of alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs) as well as by inhibitors of L- or N-type voltage-dependent calcium channels (VDCCs), whereas agonists of alpha7 nAChRs (choline, nicotine) increased the level of AChE. The results demonstrate that the effect of Abeta1-42 on AChE is due to an agonist effect of Abeta1-42 on the alpha7 nAChR.
Conformation and supramolecular arrangement of 1,3:2,4-dibenzyli-dene-D-sorbitol in solution and in single crystals (2021)

The X-ray crystal structure of the gelator 1,3:2,4-dibenzylidene-D-sorbitol (DBS) is reported here. DBS is an important gelating molecule known for nearly 130 years, that has eluded crystallization until now. The crystal obtained presents an axial stacking of DBS molecules stabilized by both Van der Waals interactions and intermolecular hydrogen bonds of the side chain hydroxyl groups with either neighboring DBS or water molecules. The crystal structure shows definitive evidence for the frequently assumed “butterfly” type aggregation mode and experimentally proves the equatorial placement of the phenyl rings. The conformation of DBS has been analyzed in the crystal structure and compared with that determined in solution through NMR spectroscopy.
Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast (2020)

Modifications found in the Anticodon Stem Loop (ASL) of tRNAs play important roles in regulating translational speed and accuracy. Threonylcarbamoyl adenosine (t<sup>6</sup>A37) and 5-methoxycarbonyl methyl-2-thiouridine (mcm<sup>5</sup>s<sup>2</sup>U34) are critical ASL modifications that have been linked to several human diseases. The model yeast <i>Saccharomyces cerevisiae</i> is viable despite the absence of both modifications, growth is however greatly impaired. The major observed consequence is a subsequent increase in protein aggregates and aberrant morphology. Proteomic analysis of the t<sup>6</sup>A-deficient strain (<i>sua5</i> mutant) revealed a global mistranslation leading to protein aggregation without regard to physicochemical properties or t<sup>6</sup>A-dependent or biased codon usage in parent genes. However, loss of sua5 led to increased expression of soluble proteins for mitochondrial function, protein quality processing/trafficking, oxidative stress response, and energy homeostasis. These results point to a global function for t<sup>6</sup>A in protein homeostasis very similar to mcm<sup>5</sup>/s<sup>2</sup>U modifications.
Aplysia Californica Neurons Express Microinjected Neuropeptide Genes (1987)

Neuropeptide genes are expressed in specific subsets of large polyploid neurons in Aplysia californica. We have defined the transcription initiation sites of three of these neuropeptide genes (the R14, L11, and ELH genes) and determined the nucleotide sequence of the promoter regions. The genes contain the usual eucaryotic promoter signals as well as other structures of potential regulatory importance, including inverted and direct repeats. The L11 and ELH genes, which are otherwise unrelated, have homology in the promoter regions, while the R14 promoter was distinct. When cloned plasmids were microinjected into Aplysia neurons in organ culture, transitions between supercoiled, relaxed circular, and linear DNAs occurred along with ligation into high-molecular-weight species. About 20% of the microinjected neurons expressed the genes. The promoter region of the R14 gene functioned in expression of the microinjected DNA in all cells studied. When both additional 5' and 3' sequences were included, the gene was specifically expressed only in R14, suggesting that the specificity of expression is generated by a multicomponent repression system. Finally, the R14 peptide could be expressed in L11, demonstrating that it is possible to alter the transmitter phenotype of these neurons by introduction of cloned genes.
P4‐031: A novel transgenic rat model displaying the full Alzheimer‐like amyloid pathology with early, preplaque‐stage cognitive deficits (2009)

Alzheimer's disease (AD) is a neurodegenerative disorder in which amyloid-beta (Aβ) accumulates in different areas of the brain, leading to the deposition of amyloid plaques and the progressive decline of cognitive functions. While many transgenic mouse models of AD exist, only few rat models have been reported, most of which have failed to develop mature amyloid plaques. Here we report the generation and characterization of a new transgenic rat line, coded McGill-R-Thy1-APP, with an early intracellular (Aβ) accumulation phase and later phase of amyloid plaque deposition. A transgenic rat line has been developed that expresses the human amyloid precursor protein (APP) carrying both the Swedish and Indiana mutations under the control of the murine Thy1 promoter. Amyloid pathology, cognitive deficits and levels of phosphorylation of synaptic plasticity-related ERK1/2 and CREB proteins were investigated by immunohistochemistry and Western blot analysis while learning and memory was assessed with the Morris Water Maze. McGill-R-Thy1-APP transgenic rats display an early phase of abnormal (AD-like) intraneuronal Aβ (iAβ) accumulation widespread throughout the cerebral cortex and the hippocampal formation. In the neocortex, the iAβ accumulation is most notable in pyramidal neurons of lamina 5, but also ubiquitously present in all cortical layers. iAβ accumulation progressively increases with aging, leading to the formation of extracellular Aβ amyloid plaques by 6 to 13 months of age. Amyloid plaques are initially detected in the hippocampus and spread, with time, to the cerebral cortex. Cognitive deficits are apparent as early as 3 months of age and worsen with the intracellular and extracellular Aβ load. These transgenic rats also reveal a dysregulation of the ERK1/2 phosphorylation suggesting a compromise of cell signalling and synaptic plasticity mechanisms. Our results support the idea that AD-like iAβ accumulation- in absence of extracellular amyloid material deposition- is sufficient to interfere with higher CNS functions such as learning and memory. The characterization of this transgenic model is currently being completed, with particular attention being given to the effect of iAβ on the disruption of the cell signalling pathways involved in memory formation.
Modulational instability in dusty plasmas (1995)

Self-consistent equations for ion density, envelope electric fields, and charge variations of dust particles are obtained for a dusty plasma. A new type of modulational instability of Langmuir waves related to dust charging processes is found.
Solution pyrolysis kinetics utilizing NMR spectra. A laboratory experiment (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolution pyrolysis kinetics utilizing NMR spectra. A laboratory experimentB. L. Stump , R. M. Ottenbrite , and J. W. Brockington Cite this: J. Chem. Educ. 1976, 53, 4, 257Publication Date (Print):April 1, 1976Publication History Received3 August 2009Published online1 April 1976Published inissue 1 April 1976https://doi.org/10.1021/ed053p257RIGHTS & PERMISSIONSArticle Views118Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Numerical simulation of gas distribution in goaf under Y ventilation mode (2018)

Taking the Y type ventilation of the working face as the research object, diffusion equation is introduced to simulate the diffusion characteristics of gas, using Navier-Stokes equation and Brinkman equation to simulate the gas flow in working face and goaf, the physical model of gas flow in coal mining face was established. With numerical simulation software COMSOL multiphysics methods, gas distribution in goaf under Y ventilation mode is simulated and gas distribution of the working face, the upper corner and goaf is analysised. The results show that the Y type ventilation system can effectively improve the corner gas accumulation and overrun problem.
Safety Profile of Maintenance Obinutuzumab in Patients with Primary CNS Lymphoma in Complete Response (2020)

Background: Although high initial response rates have been reported, fewer than 50% of newly diagnosed primary CNS lymphoma (PCNSL) patients remain disease free 2 yrs after high-dose (HD) methotrexate (MTX)-based regimens. Treatment options at relapse including HD chemotherapy with or without autologous stem cell transplantation and/or whole brain radiotherapy can lead to considerable toxicity and are not ideal especially for elderly and high-risk patients. New approaches to prolong disease control and response duration in PCNSL are needed. Maintenance rituximab has increased response duration in follicular and mantle cell lymphomas. Several reports (Ney and Abrey [2009]; Ambady et al [2020]) suggest that maintenance rituximab after achieving complete response (CR) to MTX-based chemotherapy, will prolong disease control in PCNSL. We designed a randomized study to evaluate the effect of maintenance obinutuzumab on CR duration in CD20+ B-cell PCNSL patients who attain CR to first-line HD MTX-based chemotherapy. We report adverse events (AEs) to-date in the maintenance group. Methods:This was a multicenter, non-blinded, randomized phase II study, with an estimated sample size of 120 patients randomly assigned to maintenance obinutuzumab or observation. Patients in the maintenance group received obinutuzumab (1000 mg) every 60 days for 2 yrs. Eligible patients were within 75 days of completing first-line MTX-based regimen, and in CR. The primary endpoint was CR duration. Lab tests and safety assessments were performed throughout the study until 60 days after the patient's last obinutuzumab infusion. We graded AEs according to NCI CTCAE v4, and summarized AEs descriptively. Clinical Trial Information: NCT02498951. Results: As of July 1, 2020, 24 patients were enrolled at 11 U.S. centers. Twelve patients (5F, 7M) with median age of 68 yrs (range: 39 - 82), median KPS 90 (range: 80 - 100) were in the maintenance group. Seven of the 12 patients were older than 65 yrs. The 12 patients received 87 obinutuzumab infusions (median 7 [range 2 - 12]). The only grade (Gr) 3 AEs attributable to study drug were nausea, vomiting and skin infection (1 patient [8%] each). The most frequent Gr 2 AEs were respiratory infection and diarrhea (2 patients [17%] each). Gr 2 nausea, vomiting and skin infection occurred in 1 patient (8%, each). Gr 1 dizziness and flushing during cycle 1 infusion occurred in 3 patients (25%). Conclusions: Maintenance obinutuzumab was well tolerated with an encouraging safety profile in PCNSL patients in remission. However, enrollment closed prematurely due to slow accrual made worse by the coronavirus pandemic. Thus the role of maintenance obinutuzumab in prolonging CR duration in this patient population remains unknown. Disclosures Barth: Sanofi:Membership on an entity's Board of Directors or advisory committees.
Abstract LB-327: Targeted microbeads for attraction and induction of specific innate immune response in the tumor microenvironment (2010)

Abstract Anti-tumor activity of molecules and cells of the innate immune system has been reported. Here we propose a method for targeting preferred innate immune cells and magnifying their tumoricidal effect at the tumor microenvironment, by modular multiple-component complexes. As a model, micro-complexes carried monoclonal anti-HER2 antibodies, lipopolysaccharide and mannose. The complexes showed high binding capacity to HER2-positive cancer cells in vitro, high induction of interleukin-1 RNA transcription by the activated monocytes and ability to mediate monocytes’ attachment to HER2-positive cells. We thus present a new vision of targeting a desired innate immune response to the tumor microenvironment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-327.
Use of RecA protein to enrich for homologous genes in a genomic library (1988)

RecA protein-coated probe has been utilized to enrich genomic digests for desired genes in order to facilitate cloning from genomic libraries. Using a previously cloned HLA-B27 gene as the recA-coated enrichment probe, we obtained a mean 108x increase in the ratio of specific to nonspecific plaques in lambda libraries screened for B27 variant alleles of estimated 99% homology to the probe. Class I genes of lesser homology were less enriched: 6.7x for non-B27 genes of estimated greater than 95% homology and 3.7x for other-Class I genes of greater than 80% homology. Loss of genomic DNA during the enrichment procedure can, however, restrict application of this technique whenever starting genomic DNA is very limited. Nevertheless, the impressive reduction in cloning effort and material makes recA enrichment a useful new tool for cloning homologous genes from genomic DNA.
Metabolism by rat liver cytosol of illudin S, a toxic substance of Lampteromyces japonicus. II. Characterization of illudin S-metabolizing enzyme (1992)

1. Enzyme systems responsible for formation of cyclopropane ring-cleavage metabolites (M1 and M2) of illudin S in rat liver were characterized. 2. The enzymes were localized in the cytosol fraction and utilized NADPH alone as electron donor; they were not affected by oxygen and had low pH optima. 3. Formation of metabolites M1 and M2 was inhibited completely by dicumarol (10(-4) M), an inhibitor of DT-diaphorase. 4. Menadione (10(-4) M) and quercetin (10(-4) M) both inhibited formation of M1 and M2 by 35% and 15%, respectively, but quinacrine, barbital, pyrazole and p-chloromercuribenzoic acid had no significant effect. 5. Results show that the enzyme systems may differ from DT-diaphorase, aldehyde oxidase, xanthine oxidase, ketone reductase, aldose reductase, aldehyde reductase and alcohol dehydrogenase, known cytosolic enzymes responsible for xenobiotic metabolism.
A Wireless Inductive-Capacitive Resonant Circuit Sensor Array for Force Monitoring (2013)

A wireless passive sensor array based on inductive-capacitive (LC) resonant circuits capable of simultaneously tracking two points of force loading is described. The sensor consisted of a planar spiral inductor connected to two capacitors forming a resonant circuit with two resonant frequencies. When a load was applied to one or both of the parallel plate capacitors, the distance between the plates of the capacitor was altered, thus shifting the observed resonant peaks. Testing illustrated that applied loading to a particular capacitor caused a significant shift in one of the resonant peaks and also a smaller shift in another resonant peak. This interdependence resulted from each capacitive element being connected to the same inductive spiral and was accounted for with a developed analysis algorithm. To validate the experimental observation, a circuit simulation was also generated to model the sensor behavior with changing force/displacement. The novelty of this system lies not only in its wireless passive nature, but also in the fact that a single LC sensor was fashioned to detect more than one point simultaneously.
Severe posttraumatic craniocervical instability in the very young (2004)

✓ Children younger than 3 years of age represent a distinct subpopulation of patients at particular risk for high cervical and craniovertebral injuries. There are few descriptions of survivors of severe craniocervical trauma among the very young, and scarce data exist regarding management after initial emergency stabilization. The authors describe three children, age 1 to 32 months, who presented with craniocervical junction injuries. Variable neurological findings were observed at presentation (cranial nerve deficits, obtundation, and moderate-to-severe quadriparesis). All three were treated with prolonged immobilization and have recovered with minimal to no neurological deficit.