gebhart/patrepeval huggingface dataset:
Demo: EdgeNet, a Production Internet-Scale Container-Based Distributed System Testbed (2022)

The EdgeNet software is free, open-source, liberally licensed code that extends the Kubernetes container orchestration system to the edge cloud. We use this code to run the EdgeNet testbed, an internet-scale edge cloud for distributed systems researchers. This demonstration showcases three features of EdgeNet: its multitenancy model, its multi-provider aspect, and its geographically-based selective deployment capability. Multitenancy allows multiple teams to use the platform concurrently; being multi-provider, independent contributors can make nodes available to the platform; and selective deployment facilitates location-based placement of software. Under our guidance, demo participants invoke the Kubernetes command-line interface to use the testbed. In so doing, they get experience with the testbed, which they can continue to use afterwards. They also gain insight into how the demonstrated features are useful for edge cloud container deployment in general. Participants who volunteer to help EdgeNet nodes receive Odroid devices to host in their homes or workplaces.
Evaluation of visual servoing control of aerial manipulators using test gantry emulation (2014)

Unmanned Aerial Vehicles (UAVs) offer a means to vastly expand a manipulator's reach. Mounting an arm to a UAV greatly increases the utility of both the arm and the UAV. This paper describes the application of partitioning to control the redundant degrees of freedom of an emulated aerial manipulation system. Visual servoing is used to drive the end-effector pose relative to a target, treating relative motions between the host vehicle and target as perturbations. The position of the host platform, emulated by a gantry, is servoed using kinematic information from the manipulator in such a way that it enables the arm to return to a pose with a high degree of reachability while imposing minimal static torque on the host. A prototype system is implemented and evaluated using a 6-DOF manipulator and a gantry in place of a flying UAV. The partitioning algorithm is exercised as a proof of concept motivating the future use of this approach on a flying platform, though further refinement is required before this goal may be realized.
Potential Role of Insulinlike Growth Factors in Fracture Healing (1998)

Several lines of evidence suggest that the insulinlike growth factors play a role in fracture healing. They promote cell proliferation and matrix synthesis by chondrocytes and osteoblasts, the two cell types largely responsible for the formation of fracture callus. Circulating levels of insulinlike growth factor I and bone mineral density decrease with increasing age, and administration of insulinlike growth factor I increases bone turnover in patients with low bone mineral density. Insulinlike growth factor I may accelerate the normal healing of intramembranous bone defects, inducing the healing of defects that otherwise would not heal. An important role of insulinlike growth factor I is to mediate many of the actions of growth hormone on the skeleton. Considerable effort has been devoted to testing the effect of growth hormone and, thereby, indirectly that of insulinlike growth factor I on fracture healing. These studies have yielded such disparate results that no general conclusions regarding the effect of growth hormone (or of growth hormone dependent insulinlike growth factor I) on fracture healing currently can be drawn. Additional studies are needed to clarify the role of the insulinlike growth factors in the fracture healing process and to determine how their anabolic actions can be enlisted in the clinical enhancement of fracture healing.
Efficient Interconnection for Modern Computing Systems (2014)

Direct replacement of point-to-point electrical links with optics in servers and large computing systems (e.g., datacenters) is not necessarily energy-efficient. Alternative approaches and recent experimental development will be discussed towards more efficient interconnection networks.
Assessment of Optical Turbulence Profiles Derived from Probabilistic Climatology (2007)

This research e ort assesses the performance of the High Energy Laser End-to-End Operational Simulation (HELEEOS) Climatological C2noptical turbulence model. Path-integrated C2nvalues of two HELEEOS optical turbulence pro les at 3 distinct operational altitudes are compared to values determined from measured thermosonde data. HELEEOS desert and mid-latitude sites are selected from the Extreme and Percentile Environmental Reference Tables (ExPERT) database for comparison to the thermosonde data. Statistical equivalence of the two datasets is determined through a Design of Experiments (DOE) factorial test to within 80% con dence. The HELEEOS pro les are shown to be equivalent to the thermosonde data for a 500 m boundary layer pro le. Deterministic values of the 80% con dence intervals are established. The HELEEOS optical turbulence model is used as the input turbulence model for wave optics simulations. Long-term spot size measurements show that HELEEOS outperforms empirical turbulence models by as much as 17%. Recommendations are made to improve the HELEEOS graphical outputs and reference tables.
Capacity Building Programs for Library Professionals: Challenges and Opportunities (2019)

The quality of a library is identified by its competent staff, dynamic services, and updated resources. The human resources working in the Library and Information Centre are needed to enhance their personal as well as professional level skills and competence for effective delivery of library and information services. The present study discusses on the concept, method, and levels of Capacity Building Programs for library professionals in library and information centres. Further the study discusses on need of capacity building programs and throws lights on some major challenges persist with it.
Abstract WP181: Linking Post-Stroke Injury, Neural Function, and Motor Behavior With EEG (2019)

Introduction: Elucidating the relationship between stroke-induced injury and changes in neural function may potentiate rehabilitation and treatment development. This study examined post-stroke associations between functional electroencephalography (EEG) measures, structural injury, and motor behavior. Hypothesis: Greater injury extent and motor impairment correspond to increasing delta band (1-3Hz) and decreasing high beta band (20-30Hz) EEG measures in a time-dependent manner. Methods: Subjects with stroke completed a 3-minute resting-state EEG recording, an MRI, and motor testing (Fugl-Meyer, FM). EEG power and ipsilesional primary motor cortex (M1) coherence (connectivity) were computed from dense-array EEG (194 leads). Global (lesion volume) and motor-specific (%CST injury) injury were measured on MRI. Associations between EEG measures and injury/behavior were significant if ≥10% of leads demonstrated significance (p≤0.05). Results: Sixty individuals (mean age 56.6 years, 11.9 months post-stroke) were stratified into subacute (n=24) and chronic (n=36) groups. For EEG power, larger delta band power correlated strongly with increasing lesion volume early after stroke, and this association expanded (21 to 82 leads) in chronic stroke to bilateral premotor, M1, and temporal-parietal regions. This delta power expansion strongly correlated with greater FM scores. For EEG coherence, larger delta band ipsilesional M1 coherence with leads overlying bilateral fronto-temporal-parietal regions strongly correlated with both greater lesion volume (64 leads) and CST injury (52 leads) early after stroke. These associations were reduced in chronic stroke but still strongly correlated with greater FM scores. Beta band power and coherence measurements showed negative and positive correlations with lesion volume, respectively, but did not relate to motor behavior. Conclusions: Low-frequency band EEG power and coherence measures predominantly capture global injury arising from stroke. The expansion of delta power and the reduction of delta coherence from subacute to chronic stroke are adaptive responses indicative of lower motor impairment, and these measures may prove valuable in monitoring stroke rehabilitation.
Dynamically Calibrated Simulation of a Refrigeration Cycle for Household Freezers (2018)

The development process of energy-efficient household refrigerators and freezers is characterized by time-consuming and expensive experiments. In order to make this development process more efficient, dynamic (transient) models of the individual components of the entire refrigeration cycle were developed at Graz University of Technology. To ensure operability beyond the research project and to enable industrial application, these models have been implemented in the commercial software IPSEpro. The advantage of using such a simulation tool is the simplicity of conducting parameter studies as well as performing design modification to the device. This work includes modelling approaches of each refrigeration cycle component and the freezer model. Since the model parameter values are unknown and in order to calibrate the freezer model with measurement data, a semi-automatic method for model calibration was developed. Due to interactions and nonlinear dependencies between the model parameters, a manual parameter optimization would be very time consuming and inefficient. The semi-automatic calibration method is capable to handle a large parameter set in a fast and user-friendly way. Furthermore, results of the validated freezer model are presented, followed by an application demonstration of the simulation model.
Long-term memory motion-compensated prediction (1999)

Long-term memory motion-compensated prediction extends the spatial displacement vector utilized in block-based hybrid video coding by a variable time delay permitting the use of more frames than the previously decoded one for motion compensated prediction. The long-term memory covers several seconds of decoded frames at the encoder and decoder. The use of multiple frames for motion compensation in most cases provides significantly improved prediction gain. The variable time delay has to be transmitted as side information requiring an additional bit rate which may be prohibitive when the size of the long-term memory becomes too large. Therefore, me control the bit rate of the motion information by employing rate constrained motion estimation. Simulation results are obtained by integrating long-term memory prediction into an H.263 codec. Reconstruction PSNR improvements up to 2 dB for the Foreman sequence and 1.5 dB for the Mother-Daughter sequence are demonstrated in comparison to the TMN-2.0 H.263 coder. The PSNR improvements correspond to bit-rate savings up to 34 and 30%, respectively. Mathematical inequalities are used to speed up motion estimation while achieving full prediction gain.
Data from Aflibercept (VEGF Trap) in Inoperable Stage III or Stage IV Melanoma of Cutaneous or Uveal Origin (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Aflibercept is a soluble decoy VEGF receptor and angiogenesis inhibitor with potent preclinical antitumor activity in melanoma. We conducted a multicenter phase II study in patients with inoperable stage III or IV melanoma and no prior chemotherapy.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; A two-stage design was adopted to evaluate 4-month progression-free survival rate (PFSR) and response rate. Aflibercept was given at 4 mg/kg intravenously every 2 weeks. Response was assessed every 8 weeks. First-stage accrual of 21 patients was specified and with an adequate 4-month PFSR accrual continued to a total of 41.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Forty-one patients of ages 23 to 84 (median = 57) were enrolled. Thirty-nine had American Joint Committee on Cancer stage IV (5 M1a, 7 M1b, and 27 M1c) and 2 had inoperable stage IIIC (N3). Eastern Cooperative Oncology Group (ECOG) performance status was 0 (27 patients) or 1 (14 patients). Ten patients had primary uveal melanoma, 28 cutaneous, and 3 had unknown primaries. A median of 7 cycles were initiated (range: 1–56). Grade 3 and 4 toxicities included hypertension in 9 patients (22%) and proteinuria in 6 (15%). Among 40 patients evaluable for efficacy (those who initiated aflibercept), 3 (7.5%) had a confirmed partial response and 20 had progression-free survival of 4 months or above. The predicted 1-year survival rate derived from the Korn meta-analysis model is 36% (&lt;i&gt;N&lt;/i&gt; = 39), whereas we observed a corresponding 56.4% survival rate at 1 year (95% CI, 43–74, &lt;i&gt;P&lt;/i&gt; &lt; 0.005). Median overall survival in this trial is 16.3 months (95% CI, 9.2 to not reached). We observed a significant association between severity of hypertension following aflibercept and survival improvement.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Aflibercept showed promising activity in patients with metastatic melanoma of cutaneous or uveal origin. Further evaluation of aflibercept as a single agent and in combination is warranted. &lt;i&gt;Clin Cancer Res; 17(20); 6574–81. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Protective Immunity and Antibody-Secreting Cell Responses Elicited by Combined Oral Attenuated Wa Human Rotavirus and Intranasal Wa 2/6-VLPs with MutantEscherichia coliHeat-Labile Toxin in Gnotobiotic Pigs (2001)

Two combined rotavirus vaccination regimens were evaluated in a gnotobiotic pig model of rotavirus infection and disease and were compared to previously tested rotavirus vaccination regimens. The first (AttHRV/VLP2x) involved oral inoculation with one dose of attenuated (Att) Wa human rotavirus (HRV), followed by two intranasal (i.n.) doses of a rotavirus-like particle (2/6-VLPs) vaccine derived from Wa (VP6) and bovine RF (VP2) rotavirus strains. The 2/6-VLPs were coadministered with a mutant Escherichia coli heat-labile toxin, LT-R192G (mLT) adjuvant. For the second regimen (VLP2x/AttHRV), two i.n. doses of 2/6-VLPs+mLT were given, followed by one oral dose of attenuated Wa HRV. To compare the protective efficacy and immune responses induced by the combined vaccine regimens with individual rotavirus vaccine regimens, we included in the experiments the following vaccine groups: one oral dose of attenuated Wa HRV (AttHRV1x and Mock2x/AttHRV, respectively), three oral doses of attenuated Wa HRV (AttHRV3x), three i.n. doses of 2/6-VLPs plus mLT (VLP3x), three i.n. doses of purified double-layered inactivated Wa HRV plus mLT (InactHRV3x), mLT alone, and mock-inoculated pigs. The isotype, magnitude, and tissue distribution of antibody-secreting cells (ASCs) in the intestinal and systemic lymphoid tissues were evaluated using an enzyme-linked immunospot assay. The AttHRV/VLP2x regimen stimulated the highest mean numbers of intestinal immunoglobulin A (IgA) ASCs prechallenge among all vaccine groups. This regimen induced partial protection against virus shedding (58%) and diarrhea (44%) upon challenge of pigs with virulent Wa HRV. The reverse VLP2x/AttHRV regimen was less efficacious than the AttHRV/VLP2x regimen in inducing IgA ASC responses and protection against diarrhea (25% protection rate) but was more efficacious than VLP3x or InactHRV3x (no protection). In conclusion, the AttHRV/VLP2x vaccination regimen stimulated the strongest B-cell responses in the intestinal mucosal immune system at challenge and conferred a moderately high protection rate against rotavirus disease, indicating that priming of the mucosal inductive site at the portal of natural infection with a replicating vaccine, followed by boosting with a nonreplicating vaccine at a second mucosal inductive site, may be a highly effective approach to stimulate the mucosal immune system and induce protective immunity against various mucosal pathogens.
Qualitative Analysis of Acid Salts with Direct Analysis in Real Time Mass Spectrometry by Conversion to the Free Acid Form (2021)

Organic acid salts typically have very low volatility and are not well suited for analysis by Direct Analysis in Real Time mass spectrometry (DART-MS). However, qualitative analysis of organic acid salts by DART can be facilitated by the addition of a strong acid to convert the compounds to the free acid form. Examples are presented here for inorganic salts (sodium and potassium perchlorate) and several organic salts, including three disodium salts and a mixed sodium/potassium salt.
Accurate left atrium segmentation in multislice CT images using a shape model (2005)

Segmentation and labelling of the left atrium from pre-operative images could be a valuable source of information for the planning of electrophysiology procedures to cure atrial fibrillation. A method is presented that uses multi-slice computed tomography (MSCT) images for this purpose that were initially acquired for coronary assessment. The method combines the power of active shape models (robustness by use of prior anatomical knowledge) with the advantages of solely data driven segmentation methods (accuracy). A triangular shape model was built for the human left atrium and its pulmonary vein trunks. It was automatically adapted to the MSCT images, labelling these structures and segmenting them coarsely. In addition, a segmentation of the blood pool by a Hounsfield threshold was applied to the images. The enclosed volumes were triangulated to get a fine surface representation yet still including many distracting objects (the artery tree, coronaries, adjacent chambers, and bones). A correspondence between surface triangles of the coarse, but anatomically labelled model surface and those of the fine iso-surface was established by a similarity criterion on position and orientation. This allows for the refinement of the model-based segmentation showing more anatomical details by selection of corresponding parts of the iso-surface. Vice versa, the correspondence could be used to assign anatomical labels to each iso-surface patch.
Instrumentation and Controls Division biennial progress report, September 1, 1976--September 1, 1978 (1978)

Progress is summarized in the following research and development areas: electronic circuits;instruments; radiation monitoring; process systems and instrumentation; thermometry; instrumentation for engineering experiments and test loops; HTGR fuel recycle development; reactor measurements and analysis; automatic control and data acquisition; electronic engineering support for research facilities; miscellaneous engineering services, studies, and developments; maintenance; and environmental science studies.
Mixed chimerism and immunosuppressive drug withdrawal after hla-mismatched kidney and hematopoietic progenitor transplantation1 (2002)

Multilineage macrochimerism can be achieved without GVHD in HLA-mismatched recipients of combined kidney and hematopoietic progenitor transplants. Conditioning of the host with posttransplant TLI and ATG was nonmyeloablative and was not associated with severe infections. Recipients continue to be studied for the development of immune tolerance.
Epitaxial Lateral Overgrowth of GaN on Silicon (111) (2001)

Epitaxial lateral overgrowth (ELOG) of GaN was achieved on silicon (111) by metalorganic vapor phase epitaxy. Lateral expansion is obtained at high growth temperature (1120 °C), low pressure (100 mbar) and with high V/III ratio (8000). Growth rate of the (0001) c-plane and the lateral facets was investigated for stripes along the [100]GaN and the [110]GaN crystallographic directions. Although full coalescence is more difficult on Si (111) substrate than on sapphire, ELOG process with large mask is possible with stripes oriented along the [100]GaN axis. Coalescence can be achieved with a 10 μm period mask with an overgrown layer thickness lower than 3 μm. Atomic force microscopy and transmission electron microscopy are used to characterize the quality of the layers. The density of dislocations can be decreased from 8 × 109 cm—2 in the underlying layer of GaN down to 5 × 107 cm—2 in the laterally overgrown region, and 8 × 108 cm—2 in the opening of the mask. Cathodoluminescence was used to determine the stress in the ELOG layer before and after coalescence.
Pick your poison (2016)

As mosquitoes develop resistance to pyrethroid insecticides, researchers are forced to look for alternatives
Robust design of large-displacement compliant mechanisms (2011)

Abstract. The aim of this article is to introduce a new topology optimisation formulation for optimal robust design of Micro Electro Mechanical Systems. Mesh independence in topology optimisation is most often ensured by using filtering techniques, which result in transition grey regions difficult to interpret in practical realisations. This problem has been alleviated recently by projection techniques, but these destroy the mesh independence introduced by the filters and result in single node connected hinges. Such features in the design are undesirable as they are not robust with respect to geometric manufacturing errors (such as under/over etching). They can be avoided by optimising for several design realisations which take into account the possible geometry errors. The design variations are modelled with the help of random variables. The proposed stochastic formulation for the design variations results in nearly black and white mechanism designs, robust with respect to uncertainties in the production process, i.e. without any hinges or small details which can create manufacturing difficulties.
ChemInform Abstract: Synthesis and Biological Activity of New Conformationally Restricted Analogues of Pepstatin. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nouvelles methodes de formation de liaisons carbone-carbone catalysee par les complexes du ruthenium (2000)

La capacite catalytique du complexe riche en electrons cp*ru(cod)cl a ete mise en evidence pour la formation de liaisons carbone-carbone dans des reactions nouvelles. La reaction de couplage catalytique effectuee sur deux molecules d'alcyne et une molecule d'acide carboxylique conduit a une synthese originale d'esters de dienol. L'intermediaire cle de cette transformation, correspondant a un couplage regioselectif tete-tete des deux alcynes, est une espece bis carbene du ruthenium. Cette reaction est selective puisqu'elle conduit a la formation d'un seul compose de stereochimie e,e. L'adaptation de cette reaction aux alcools propargyliques a conduit a la decouverte d'une nouvelle reaction donnant acces a des cyclobutenes fonctionnels par combinaison de deux triples liaisons et d'un acide carboxylique. La reaction a egalement pu etre etendue aux phenols. Les etudes mecanistiques ont permis de determiner qu'un complexe ruthenium cyclobutadiene est une des especes catalytiques de cette reaction. La protonation de ce dernier a conduit a la caracterisation, par diffraction x, d'un intermediaire modele de cette reaction. L'utilisation du catalyseur cp*ru(cod)cl en milieu protique a permis de decouvrir une nouvelle application permettant la cycloisomerisation de 1,6-enynes en dialkylidene tetrahydrofuranes. Les dialkylidenetetrahydrofuranes sont obtenus sous la forme d'un seul stereoisomere. La reaction catalytique entre deux molecules de diazoalkane et un alcyne a permis de deceler une transformation conduisant a la double addition selective de trimethylsilyldiazomethane sur un alcyne donnant acces a des bisvinylsilanes, les 1,3-dienes-1,4-disilyles. Elle montre egalement le caractere bis carbenique d'un alcyne. Ces quatre reactions constituent des contributions a la combinaison de plusieurs reactifs en un seul produit, avec conservation d'atomes, et a l'elaboration de procedes chimiques propres.