gebhart/patrepeval huggingface dataset:
M-FAMA: A multi-session MAC protocol for reliable underwater acoustic streams (2013)

Mobile underwater networking is a developing technology for monitoring and exploring the Earth's oceans. For effective underwater exploration, multimedia communications such as sonar images and low resolution videos are becoming increasingly important. Unlike terrestrial RF communication, underwater networks rely on acoustic waves as a means of communication. Unfortunately, acoustic waves incur long propagation delays that typically lead to low throughput especially in protocols that require receiver feedback such as multimedia stream delivery. On the positive side, the long propagation delay permits multiple packets to be “pipelined” concurrently in the underwater channel, improving the overall throughput and enabling applications that require sustained bandwidth. To enable session multiplexing and pipelining, we propose the Multi-session FAMA (M-FAMA) algorithm. M-FAMA leverages passively-acquired local information (i.e., neighboring nodes' propagation delay maps and expected transmission schedules) to launch multiple simultaneous sessions. M-FAMA's greedy behavior is controlled by a Bandwidth Balancing algorithm that guarantees max-min fairness across multiple contending sources. Extensive simulation results show that M-FAMA significantly outperforms existing MAC protocols in representative streaming applications.
Biomaterials Approaches to Combating Oral Biofilms and Dental Disease (2006)

Possibilities for biomaterials to impact the dental caries epidemic are reviewed with emphasis placed on novel delivery biomaterials and new therapeutic targets.
Automatically generating Wikipedia articles (2009)

In this paper, we investigate an approach for creating a comprehensive textual overview of a subject composed of information drawn from the Internet. We use the high-level structure of human-authored texts to automatically induce a domain-specific template for the topic structure of a new overview. The algorithmic innovation of our work is a method to learn topic-specific extractors for content selection jointly for the entire template. We augment the standard perceptron algorithm with a global integer linear programming formulation to optimize both local fit of information into each topic and global coherence across the entire overview. The results of our evaluation confirm the benefits of incorporating structural information into the content selection process.
Gas separation with glass membranes. Final report (1992)

The Department of Energy (DOE) is seeking to develop high temperature, high pressure inorganic membrane technology to perform a variety of gas separation processes to improve the efficiency and economics of advanced power generation systems such as direct coal-fueled turbines (DCFT) and the integrated gasification combined cycle process (IGCC). The temperatures encountered in these power generation systems are far above the temperature range for organic membrane materials. Inorganic materials such as ceramics are therefore the most likely membrane materials for use at high temperatures. This project focussed on silica glass fiber membranes made by PPG Industries (Pittsburgh, PA). The goals were both experimental and theoretical. The first objective was to develop a rational theory for the performance of these membranes. With existing theories as a starting point, a new theory was devised to explain the unusual ``molecular sieving`` behavior exhibited by these glass membranes. An apparatus was then devised for making permeation performance measurements at conditions of interest to DOE (temperatures to 2000{degrees}F; pressures to 1000 psia). With this apparatus, gas mixtures could be made typical of coal combustion or coal gasification processes, these gases could be passed into a membrane test cell, and the separation performance determined. Data were obtained for H{sub 2}/CO,N{sub 2}/CO{sub 2}, 0{sub 2}/N{sub 2}, and NH{sub 3}/N{sub 2} mixtures and for a variety of pure component gases (He, H{sub 2}, CO{sub 2}, N{sub 2}, CO, NH{sub 3}). The most challenging part of the project turned out to be the sealing of the membrane at high temperatures and pressures. The report concludes with an overview of the practical potential of these membranes and of inorganic membranes in general of DOE and other applications.
A Reduced Switch Five-Level VSI for High-Performance Vector Controlled PMSM Drive (2020)

This work presents the strategy for vector control of permanent magnet synchronous motor (PMSM) drive fed with a three-phase multi-level voltage source inverter for high performance. In the present work, the traditional 2-level inverter is replaced with a novel reduced switch 5-level inverter, and comparative analysis is done. The implementation of the five-level inverter improves the torque, stator current, and mechanical dynamics of the drive. Here PWM technique is employed to generate the gate pulses for switching devices in a planned sequence to obtain five-level output voltage. The 12 operating modes are defined for reduced switch 5-level inverter that produces voltages as 0, ±2Vdc/3, ±Vdc, ±4Vdc/3 with reduced total harmonics distortion (THD). The close-loop vector control of PMSM with developed five-level inverter is implemented to improve the performance of drive in terms of rise time, settling time, stator current harmonics. The overall system is developed in MATLAB/Simulink and investigations are done in different input command and loading conditions. An extensive simulation study and analysis of results reveal the potential of the present work. This work mainly focuses on the reduction of motor electromagnetic torque pulsations along with improved speed response.
Preliminary process studies for bioremediation of PAH impacted soil (1994)

Soil impacted with polycyclic aromatic hydrocarbons (PAHs) pose a major hazard to human life. To avoid further contamination, these soils need to be treated. The treatment can be chemical, physical, by supercritical extraction, or using other novel methods. The treatment choice is, however, governed by process economics. Biological methods are inherently very versatile, less expensive, and environmentally friendly. They operate at moderate conditions of temperature, pressure, and can be scaled up easily. It is of interest to do preliminary studies on the bioremediation of PAH impacted soils. The first step in a preliminary study is to identify the types and composition of contaminants in the soil. Then the physical and chemical properties data of these contaminants are considered. Based on these studies, a choice of microbial culture is made, from indigenous or acclimated strains of bacteria or fungi, which can efficiently consume these contaminants. Process conditions of temperature, alternate carbon and nitrogen sources, mixing, aeration, and moisture content were studied to achieve optimum contaminant removal.
Preliminary Studies of New Proteasome Inhibitors in the Tumor Targeting Approach: Synthesis and in Vitro Cytotoxicity (2005)

The proteasome is a multicatalytic protease that plays a critical role in the cell. The control of proteasomes could, thus, provide a weapon for the treatment of cancer. Therefore, we have synthesized six new peptide aldehyde inhibitors of the proteasome linked to the N-(2-diethylaminoethyl)benzamide (BZA-CO) structure, in order to target the cytotoxic activity to malignant melanoma cells. Biological studies demonstrated the influence of length and composition of the amino acid chain on the cytotoxicity of our compounds. Among them, compound 19 presents the highest cytotoxicity (IC50 = 0.64 +/- 0.07 micromol): this cytotoxicity was maintained in the presence of BZA-CO but decreased 8-fold compared to the control MG132. Fluorescence activated cell sorter (FACS) and cytotoxic activity analysis demonstrated the selectivity of compound 19 for melanoma cells. Finally, western blottings of ubiquitinated proteins in IPC227F cells as well as proteasome assays confirmed that the cytotoxicity was linked to an inhibition of the proteasome activity.
Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition (1997)

To determine whether a functional type II receptor of transforming growth factor beta (TGF-beta) is required to mediate the growth inhibitory effect of TGF-beta on the skin in vivo, we have generated transgenic mice that overexpress a dominant negative-type II TGF-beta receptor (delta beta RII) in the epidermis. The delta beta RII mice exhibited a thickened and wrinkled skin, and histologically the epidermis was markedly hyperplastic and hyperkeratotic. In vivo labeling with BrdUrd showed a 2.5-fold increase in the labeling index over controls, with labeled nuclei occurring in both basal and suprabasal cells of transgenic epidermis. In heterozygotes, this skin phenotype gradually diminished, and by 10-14 days after birth the transgenic mice were indistinguishable from their normal siblings. However, when F1 mice were mated to homozygosity, perinatal lethality occurred due to the severe hyperkeratotic phenotype, which restricted movement. Cultured primary keratinocytes from delta beta RII mice also exhibited an increased rate of growth in comparison with nontransgenic controls, and were resistant to TGF-beta-induced growth inhibition. These data document the role of the type II TGF-beta receptor in mediating TGF-beta-induced growth inhibition of the epidermis in vivo and in maintenance of epidermal homeostasis.
Intradermal vaccination prevents anti-MOG autoimmune encephalomyelitis in macaques (2019)

We show that the delivery of an anti-DC-ASGPR-MOG allows antigen-specific adaptive immune modulation to prevent the breach of immune tolerance to MOG. Our findings pave the way for therapeutic vaccines for long-lasting remission to grave encephalomyelitis with identified autoantigens, such as ADD associated with anti-MOG autoantibodies. FUND: Work supported by the French ANR (ANR-11-INBS-0008 and ANR-10-EQPX-02-01), NIH (NIH 1 R01 AI 105066), the Baylor Scott and White Healthcare System funding and Roche Research Collaborative grants.
An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: A three‐month randomized, placebo‐controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents (2010)

Our findings indicate that there were no differences in the primary end point between the R788 and placebo groups. Differences were observed between the R788 and placebo groups in secondary end points, particularly in those patients who entered the study with an elevated CRP level.
Horizontal homogeneity and vertical extent of new particle formation events (2007)

During the SATURN campaign 2002, new particle formation, i.e. the occurrence of ultrafine particles was investigated simultaneously at four ground-based measurement sites. The maximum distance between the sites was 50 km. Additionally, vertical profiles of aerosol particles from 5–10 nm have been measured by a tethered-balloon-borne system at one of the sites. In general, two different scenarios have been found: (i) new particle formation was measured at all sites nearly in parallel with subsequent particle growth (homogeneous case) and (ii) new particle formation was observed at one to three sites irregularly (inhomogeneous case) where subsequent particle growth was often interrupted. The homogeneous case was connected with stable synoptical conditions, i.e. the region was influenced by a high pressure system. Here, the horizontal extent of the phenomenon has been estimated to be 400 km at maximum. In the vertical dimension, the ultrafine particles are well mixed within the entire boundary layer. In the inhomogeneous case the new particle formation depends mainly on the incoming solar radiation and was often interrupted due the occurrence of clouds. Thus, single point measurements are not representative for a larger region in that case.
CFRP Bonding Pre-Treatment with Laser Radiation of 3 μm Wavelength: A Robust Solution for Industrial Applications (2018)

Due to a reduced structural weight, composite parts offer the possibility to increase the eco-efficiency of any mobility devices during their lifetime. Due to the mold-based production of composite parts, their surfaces are contaminated with release agent residues (e.g. silicones). Thus, the adhesion of the part’s surface is lowered, which prevent structural adhesive bonding of untreated parts. To enable this joining technology and guarantee a sufficient adhesion during part’s lifetime, a surface pre-treatment prior to the bonding process has to be performed. A laser treatment shows a high potential for an integration in an industrial process chain, but unfortunately, common laser sources lower this potential due to high investment costs (excimer laser) or the risk of causing material damage (lasers emitting in the range of 1 μm wavelength). To solve this challenge, laser radiation at 3 μm wavelength, which has several advantages (high absorption within epoxy resin, less thermal interaction concluding less risk to cause delaminations and the possibility to be guided through a fiber) was generated by frequency conversion of an industrial ND:YAG laser (at 1064 nm) and applied to the composite. The results show a good and sensitive treatment of the surface, resulting in high bonding strengths and providing a robust pre-treatment method.
Importance of conformation on the neutralizing antibody response to HIV-1 gp120. (1991)

We have investigated the role of conformation of HIV-1 gp120 on its potential efficacy as a subunit vaccine. The questions that we set out to answer were: 1) Are there neutralizing antibodies directed to conformational epitopes in gp120? 2) If so, what is the spectrum of virus isolates neutralized by these antibodies? 3) Is a conformationally correct gp120 subunit more effective in the induction of neutralizing antibodies than a denatured subunit? 4) Does native gp120 subunit vaccination induce a broader neutralizing response than a gp120 antigen that cannot display conformational epitopes? To address these questions, we characterized the gp120-specific antibody response of HIV-1-infected humans and of experimental animals immunized with recombinant native and nonnative gp120 subunits. Two versions of recombinant gp120 produced from the HIV-SF2 isolate of HIV-1 were employed in these studies: 1) a nonglycosylated, denatured version produced in genetically engineered yeast, which we presume is capable of presenting only linear determinants, and 2) a fully glycosylated, native version, produced in genetically engineered mammalian cells, that is capable of displaying linear as well as conformational epitopes. Antibodies directed exclusively to conformational epitopes in gp120 were purified from pooled HIV antibody-positive human sera using these two versions of HIV-SF2 gp120. These antibodies exhibited neutralizing activity, and this activity was effective in the neutralization of a different, broader spectrum of HIV-1 isolates than that of antibodies to linear determinants in gp120 purified from the same serum pool. When these two versions of HIV-SF2 gp120 were used as subunit immunogens in baboons, clear differences in their abilities to elicit neutralizing antibodies were observed. The native version was more effective in the induction of neutralizing antibodies effective against HIV-SF2, the homologous virus isolate. The isolate specificity of the neutralizing response to these two versions of HIV-SF2 gp120 also differed. The nonglycosylated version induced neutralizing antibodies that were effective against only the isolate, or closely related isolates, from which the antigen was derived. In contrast, the native version induced a neutralizing response that was effective against a broad panel of HIV-1 isolates, including at least one isolate that one would not expect to be neutralized by antibodies to the PND of HIV-SF2 gp120.
Stable Lithium Anode of Li–O2 Batteries in a Wet Electrolyte Enabled by a High-Current Treatment (2019)

Rechargeable Li-air (O<sub>2</sub>) batteries have attracted a great deal of attention because of their high theoretical energy density and been regarded as a promising next-generation energy storage technology. Among numerous obstacles to Li-air (O<sub>2</sub>) batteries preventing their use in practical applications, water is a representative impurity for Li-air (O<sub>2</sub>), which could hasten the deterioration of the anode and accelarate the premature death of cells. Here, we report an effective in situ high-current pretreatment process to enhance the cycling performance of Li-O<sub>2</sub> batteries in a wet tetraethylene glycol dimethyl ether-based electrolyte. With the help of certain levels of H<sub>2</sub>O (from 100 to 2000 ppm) in the electrolyte, adequate Li<sub>2</sub>O formed on the lithium anode surface after high-current pretreatment, which is necessary for a robust and uniform solid electrolyte interphase layer to protect Li metal during the long-term discharge-charge cycling process. This in situ high-current pretreatment method in a wet electrolyte is shown to be an effective approach for enhancing the cycling performance of Li-O<sub>2</sub> batteries with a stable Li metal anode and promoting the realization of practical Li-air batteries.
Cell lines used in this study. (2015)

&lt;p&gt;Abbreviation: OSKM; Oct3/4, Sox2, Klf4, c-Myc, retroV; retrovirus, sendai V; sendai virus, RI; Rock Inhibitor.&lt;/p&gt;
Neonatal vitamin K administration and childhood cancer in the north of England: retrospective case-control study (1998)

It is not possible, on the basis of currently published evidence, to refute the suggestion that neonatal intramuscular vitamin K administration increases the risk of early childhood leukaemia. Any association may have been masked in earlier studies that did not use controls matched for time and locality by other unidentified factors affecting the spatiotemporal variations in incidence of leukaemia.
Solution Synthesis of BiFeO 3 Thin Films onto Silicon Substrates with Ferroelectric, Magnetic, and Optical Functionalities (2013)

Single‐ BiFeO 3 perovskite films onto Pt ‐coated silicon substrates have been fabricated by chemical solution deposition using a synthesis strategy based on the use of nonhazardous reagents. Different routes were tested to obtain precursors for the deposition of the films, inferring that bismuth ( III ) nitrate and iron ( III ) 2,4‐pentanedionate dissolved in acetic acid and 1,3‐propendiol led to the best solution. Ferroelectric, magnetic, and optical functionalities were demonstrated in these films, obtaining a high ferroelectric polarization at room temperature, ~67 μC × cm −2 , a dependence of the magnetization with the film thickness, 0.60 and 2.50 emu × g −1 for the ~215 and ~42‐nm‐thick films, and a direct band gap in the visible range, E g ~2.82 eV. These results support the interest of solution methods for the fabrication of BiFeO 3 thin films onto the silicon substrates required in microelectronic devices.
A Failure Mechanism Study of Boiler Water-Wall Tube using Numerical and Experimental Analysis (2021)

The aim of this study is to investigate the boiler tube failure mechanism using finite element analysis and experimental Analysis. The numerical software used is ANSYS steady-state thermal and static structural analysis. The independent variable for the analysis is temperature from flue gas and wall thickness of boiler tube. The scope of the study is to determine the temperature distribution, von mises stress, deformation and safety factor by implemented design of experiment. The material of boiler tube sketch in two dimensional for simulation is SA210 Grade C. this is standard requirements for the boiler made of seamless medium-carbon steel with superheater tubes according to ASTM. From the result and discussion, the potential of failure mechanism will determine upon independent variables. In addition, hoop stress or circumference stress will help to support the statement of failure of boiler tube.
An implantable device for localized drug delivery and sensing (2009)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2009.
Equivalent Structural Modeling of Wind Turbine Rotor Blade (2006)

The wind turbine rotor blade is faced with various aeroelastic problem as rotor blades become bigger and lighter by the use the composite material. The aeroelastic analysis of a wind turbine rotor blade requires its aerodynamic model and structural model. For effective aeroelastic analysis, it is required the simple and effective structural model of the blade. In the present study, we introduce the effective equivalent structural modeling of the blade for aeroelastic analysis. The equivalent beam model of the composite blade based on its 3D finite element model is established. The free vibration analysis shows that the equivalent beam model of the blade is equivalent to its 3D finite element model.
The NSE3/MAGE interactions with NSE4/EID proteins are evolutionarily conserved (2010)

Structural Maintenance of Chromosomes (SMC) complexes are involved in a wide range of cellular processes from cell division to gene regulation and DNA repair. In eukaryotes, three separate SMC protein complexes are conserved. Each contains a heterodimeric core of two SMC proteins interconnected by a kleisin subunit, together with from one to five more non-SMC elements (Nse). The complex containing SMC1 and SMC3, named cohesin, is responsible for sister chromatid cohesion during mitosis and meiosis. The condensin complex with SMC2 and SMC4 at its core is required for proper chromosome condensation and segregation during cell division. Both cohesin and condensin are also involved in gene regulation and DNA repair. The less well characterized SMC5/6 complex is involved in several DNA repair pathways. The SMC5/6 complex is composed of two subcomlexes SMC5-SMC6-Nse2 and Nse1-Nse3-Nse4. Nse3 shows sequence similarity to the Melanoma Antigen Gene (MAGE) family of proteins, which are overexpressed in certain types of cancers and whose function has been linked to cell cycle regulation, apoptosis and neuronal development. Using site-directed mutagenesis, protein-protein interaction analyses and modelling of the Schizosaccharomyces pombe Nse3 onto the crystal structure of the MAGEA4 protein, we have identified surface on the C-terminal domain of Nse3 that interacts with Nse4. The binding site for Nse4 is well conserved within the Nse3/MAGE superfamily of proteins. Nse4 is related to the EID (E1A-like inhibitor of differentiation) family of transcriptional repressors. We show that there is a relatively promiscuous interaction between members of the MAGE family and those of the EID family with some specificity. Our data suggest that the Nse3/MAGE-Nse4/EID interaction is evolutionarily conserved.