gebhart/patrepeval huggingface dataset:
Nondestructive Testing Applications for FRP Reinforced or Strengthened Concrete Elements (2023)

While inspection methods and codification of damages have been in use for a long time for conventional steel and reinforced concrete bridges, standardized and unified methodology or guide for inspection and damage detection of concrete elements reinforced or strengthened with FRP does not exist. Despite many advantages provided by Fiber reinforced polymers (FRP), there have been issues and concerns associated with its use. This included some unique problems for each system in addition to possible damages and defects that include debonding, delamination, and aging from UV exposure. Lack of clear guidelines and effective methods for condition assessment of FRP reinforced/strengthened concrete (FRP-RSC) elements has noticeably dampened the proliferation of its use. Bridge owners are not comfortable with products whose condition cannot be effectively assessed and proper maintenance implemented. This study provides a unified inspection methodology tailored and enhanced specifically for FRP-RSC elements. Accordingly, this study first introduces damages and anomalies attributed to FRP-RSC bridge elements, and then investigates the application of state-of-the-art nondestructive testing (NDT) for their detection. The results of this study are expected to provide the inspection community with more clarity in the application of NDT to FRP reinforced/strengthened concrete elements. Availability of such means and methods will have exponential effects in increasing the use of FRP in civil structures.
Sarco(endo)plasmic Reticulum Ca2+ ATPase Isoforms and Their Role in Muscle Physiology and Pathology (1998)

Recent studies suggest that SR Ca2+ transport function is altered in hypertrophied and failing myocardium. To understand whether alterations in SR Ca2+ ATPase levels affect myocardial contractility, we generated transgenic mice that specifically overexpress SERCA2a or SERCA1 pump in the mouse heart, using the cardiac alpha-MHC promoter. Analysis of SERCA2a transgenic mice show both an increase in mRNA and protein levels (120-150% of the wild type). Isolated work performing heart preparations revealed that SERCA2a mice have improved myocardial performance. On the other hand, SERCA1 overexpression in the heart resulted in isoform replacement without any change in total SERCA protein. Interestingly, SERCA1 transgenic hearts exhibited super contractility with a significant increase in rates of muscle contraction (+dp/dt) and relaxation (-dp/dT). The time to peak pressure and half-time to relaxation were significantly shorter.
Non-invasive control interfaces for intention detection in active movement-assistive devices (2014)

Active movement-assistive devices aim to increase the quality of life for patients with neuromusculoskeletal disorders. This technology requires interaction between the user and the device through a control interface that detects the user's movement intention. Researchers have explored a wide variety of invasive and non-invasive control interfaces. To summarize the wide spectrum of strategies, this paper presents a comprehensive review focused on non-invasive control interfaces used to operate active movement-assistive devices. A novel systematic classification method is proposed to categorize the control interfaces based on: (I) the source of the physiological signal, (II) the physiological phenomena responsible for generating the signal, and (III) the sensors used to measure the physiological signal. The proposed classification method can successfully categorize all the existing control interfaces providing a comprehensive overview of the state of the art. Each sensing modality is briefly described in the body of the paper following the same structure used in the classification method. Furthermore, we discuss several design considerations, challenges, and future directions of non-invasive control interfaces for active movement-assistive devices.
Ectopic Pax6 Expression Disturbs Lens Fiber Cell Differentiation (2004)

The data demonstrate that high levels of Pax6 expression disrupt normal fiber cell differentiation and maturation.
Linear estimation in Krein spaces. I. Theory (1996)

The authors develop a self-contained theory for linear estimation in Krein spaces. The derivation is based on simple concepts such as projections and matrix factorizations and leads to an interesting connection between Krein space projection and the recursive computation of the stationary points of certain second-order (or quadratic) forms. The authors use the innovations process to obtain a general recursive linear estimation algorithm. When specialized to a state-space structure, the algorithm yields a Krein space generalization of the celebrated Kalman filter with applications in several areas such as H/sup /spl infin//-filtering and control, game problems, risk sensitive control, and adaptive filtering.
Dominant SIFT: A novel compact descriptor (2015)

Definition and extraction of local features play a very important role in image retrieval (IR), pattern recognition and computer vision. Fast growth of technology today calls for local features to be as compact as possible toward real-time and limited bandwidth applications. In this paper, we study the problem of representing images in a compact way to achieve low bit-rate transmission while maintaining good performance. To be more specific, we propose a novel compact descriptor, dominant SIFT, which only uses 48 bits to describe local features. Importantly, our descriptor is training-free, vocabulary-free and suitable for real-time and mobile applications. We show the effectiveness of the proposed compact descriptor in image retrieval.
Microbiome shifts and the inhibition of quorum sensing by Black Band Disease cyanobacteria (2015)

Disruption of the microbiome often correlates with the appearance of disease symptoms in metaorganisms such as corals. In Black Band Disease (BBD), a polymicrobial disease consortium dominated by the filamentous cyanobacterium Roseofilum reptotaenium displaces members of the epibiotic microbiome. We examined both normal surface microbiomes and BBD consortia on Caribbean corals and found that the microbiomes of healthy corals were dominated by Gammaproteobacteria, in particular Halomonas spp., and were remarkably stable across spatial and temporal scales. In contrast, the microbial community structure in black band consortia was more variable and more diverse. Nevertheless, deep sequencing revealed that members of the disease consortium were present in every sampled surface microbiome of Montastraea, Orbicella and Pseudodiploria corals, regardless of the health status. Within the BBD consortium, we identified lyngbic acid, a cyanobacterial secondary metabolite. It strongly inhibited quorum sensing (QS) in the Vibrio harveyi QS reporters. The effects of lyngbic acid on the QS reporters depended on the presence of the CAI-1 receptor CqsS. Lyngbic acid inhibited luminescence in native coral Vibrio spp. that also possess the CAI-1-mediated QS. The effects of this naturally occurring QS inhibitor on bacterial regulatory networks potentially contribute to the structuring of the interactions within BBD consortia.
Extended Use of Transdermal Norelgestromin/Ethinyl Estradiol: A Randomized Trial (2005)

Compared with cyclic use, extended use of the norelgestromin/ethinyl E2 transdermal patch delayed menses and resulted in fewer bleeding days. This regimen may represent a useful alternative for women who prefer fewer episodes of withdrawal bleeding.
SUNLIGHT‐INDUCED PYRIMIDINE DIMERS IN HUMAN SKIN FIBROBLASTS IN COMPARISON WITH DIMERIZATION AFTER ARTIFICIAL UV‐IRRADIATION (1988)

Abstract— We compared artificial UV‐sources such as germicidal‐ or sun‐lamps with summer noon sunlight in Switzerland for selective efficiency in the induction of pyrimidine dimers in the DNA of human cells. In our studies we determined cytosine‐thymine (C‐T) as well as thymine‐thymine dimer densities (T‐T) by high pressure liquid chromatography in cultures of xeroderma pigmentosum cells of group A. Using far‐UV light from a germicidal lamp, we found a rate of formation per Jirr 2 for C‐T and T‐T of 0.0019% and 0.0024%, respectively, of the total thymine radioactivity in hydrolysates of [ 3 H]thymidine labeled cells. After irradiation with an unfiltered sunlamp we measured a rate of formation of 0.0005% per Jm‐ 2 both for C‐T and T‐T, based on the sunlamp emission of 297 ±4 nm wavelength. Utilization of Kodacel‐ or Mylar‐filters lowered the rate of dimerization by a factor of 2 and 60, respectively. One hour of irradiation with noon summer sunlight induced 0.038 ±0.012% C‐T and 0.036 ±0.011% T‐T. This extent of dimer production is equivalent to 15 Jm ‐2 of far‐UV exposure at 254 nm.
Efficient control-oriented modelling of heterogeneous large-scale computer cooling systems (2023)

The power of modern computing equipment, from small devices such as laptops through a variety of cases up to entire data centres, makes cooling vital. Especially in large-scale systems, delivering the right cooling to the right place at the right time is crucial for both computing performance and energy efficiency. As such, modern cooling systems require a lot of controls. Given the many cases to face, designing and assessing such controls requires tools to rapidly and modularly build and manage computationally efficient simulation models, sometimes concentrating on the thermal policies aboard on a chip, sometimes on the cooling of a rack, sometimes on an entire date centre with its fluid conditioning and transport machinery, and so forth. Though technology exist to address many such cases individually, a holistic approach to embrace them all within a unified modelling methodology and workflow is still the subject of research. In this paper we distil our experience over the last years, and discuss how a solution based on joining purpose-specific chip modelling (using the 3D-ICE simulator) and Equation-Based Object-Oriented Modelling (employing the Modelica language) can help the joint design of a computing system and its cooling.
Table S2 from Molecular Insights of Pathways Resulting from Two Common PIK3CA Mutations in Breast Cancer (2023)

&lt;p&gt;Microarray results of E2 regulated genes in three cell types&lt;/p&gt;
Automated Method for Analysis of Mammographic Breast Density - A Technique for Breast Cancer Risk Estimation (2004)

Abstract : The goal of this proposed project is to develop an automated technique to assist radiologists in estimating mammographic breast density. The computerized image analysis tool can provide a consistent and reproducible estimation of percent dense area on routine clinical mammograms, thereby contributing to the understanding of the relationship of mammographic density to breast cancer risk, detection, and prognosis, and the prevention and treatment of breast cancer. During this project year, we completed the observer performance study that compared the mammographic density on digital mammograms (DMs) and digitized film mammograms fDFMs) manually segmented by experienced radiologists. The average mammographic density on digital mammograms was found to be significantly lower than that on digitized mammograms as perceived by radiologists. The lower density on DMs may improve the mammographic sensitivity for lesion detection on dense breasts. However, for patients with DFMs and DMs taken over time, comparison of serial mammograms for breast density changes will be problematic. We also performed a study to compare mammographic density segmented from DMs by our automated density segmentation program, referred to as Mammographic Density ESTimator (MDEST), with the average mammographic density manually segmented by four experienced radiologists. The mammographic density from DMs obtained by our automated MDEST program is highly correlated with the average mammographic density manually segmented by radiologists. The study therefore indicates the feasibility of using our MDEST program for estimation of mammographic density, although improvement is needed to further increase the segmentation accuracy. We will continue to improve the image analysis methods in the coming year.
Sulphonoglycolipid from the Green Alga Enteromorpha flexuosa (Wulf.) J. Ag. (1991)

The methanolic extract of the marine green alga Enteromorpha flexuosa yielded 1,2-diacyl-3-0-(6'-sulpho-ocD-quinovopyranosyl)-glycerol, the acyl component consisting of 14:0 (1.7), 15:0 (0.9), 16:0 (57.7), 18:0 (2.3), 16:1 (9Z; 1.3), 18:1 (9Z; 26.7), 18:2 (9 2 ; 2.3) and 18:2 (9Z:12Z; 6.9%) fatty acids.
Categorizing Extent of Tumor Cell Death Response to Cancer Therapy Using Quantitative Ultrasound Spectroscopy and Maximum Mean Discrepancy (2014)

Quantitative ultrasound (QUS) spectroscopic techniques in conjunction with maximum mean discrepancy (MMD) have been proposed to detect, and to classify noninvasively the levels of cell death in response to cancer therapy administration in tumor models. Evaluation of xenograft tumor responses to cancer treatments were carried out using conventional-frequency ultrasound at different times after chemotherapy exposure. Ultrasound data were analyzed using spectroscopic techniques and multi-parametric QUS spectral maps were generated. MMD was applied as a distance criterion, measuring alterations in each tumor in response to chemotherapy, and the extent of cell death was classified into less/more than 20% and 40% categories. Statistically significant differences were observed between "pre-" and "post-treatment" groups at different times after chemotherapy exposure, suggesting a high capability of proposed framework for detecting tumor response noninvasively. Promising results were also obtained for categorizing the extent of cell death response in each tumor using the proposed framework, with gold standard histological quantification of cell death as ground truth. The best classification results were obtained using MMD when applied on histograms of QUS parametric maps. In this case, classification accuracies of 84.7% and 88.2% were achieved for categorizing extent of tumor cell death into less/more than 20% and 40%, respectively.
Catalytic Asymmetric Synthesis of Acyclic Arrays by Tandem 1,4-Addition-Aldol Reactions (2006)

Herein, we report efficient acyclic stereocontrol in tandem 1,4-addition-aldol reactions triggered by catalytic asymmetric organometallic addition. Grignard reagents add to α,β-unsaturated thioesters in a 1,4-fashion and the resulting magnesium enolates are trapped with aromatic or aliphatic aldehydes. The process provides a range of tandem products bearing three contiguous stereocenters with excellent control of relative and absolute stereochemistry. The various diastereomeric products have been fully characterized using single-crystal X-ray analysis and the origins of stereocontrol in this tandem protocol are discussed. The versatility and efficiency of this methodology are demonstrated in the first catalytic asymmetric synthesis of (−)-phaseolinic acid with 54% overall yield via a short and concise route.
Pro‐ and anti‐inflammatory cytokine associations with major depression in cancer patients (2016)

Depressive symptoms in cancer patients may represent sickness behaviors, which may have distinct cytokine associations from major depression. Sickness behaviors may be associated with an increase in inflammatory cytokines, whereas major depression may be induced by a failure to adequately resolve inflammation. Our findings suggest that cytokine-mediated interventions may be of value to treat depression in this population.
Semianalytic stability algorithm in the frequency domain for interrupted milling (2023)

The construction of stability diagrams of interrupted milling cases is generally carried out by means of time-consuming numerical methods in either frequency or time domain, since the period doubling lobes arising under interrupted cutting are omitted by the time-averaged parametric scan of the traditional zeroth order approximation. This paper presents a novel seminalytic method in the frequency domain for interrupted milling. Taking advantage of their analytical chatter frequency distribution, this method adds the period doubling lobes calculated in a single frequency scan to the existing Hopf limits of the zeroth order solution. This, together with intelligent selection of scanning frequency ranges and truncation to the minimum set of harmonics, allows very fast calculation of the stability charts of interrupted milling cases while retaining the analytical basis and advantages of the zeroth order algorithm. The method accurately describes the stability limits at period doubling dominated zones and improves the existing zeroth order solution, but exhibits slight inaccuracies in the prediction of Hopf boundaries due to mode interaction and harmonic truncation effects.
Classification of Human Retinal Microaneurysms Using Adaptive Optics Scanning Light Ophthalmoscope Fluorescein Angiography (2014)

Retinal MAs can be classified in vivo into six different morphologic types, according to the geometry of their two-dimensional (2D) en face view. Adaptive optics scanning light ophthalmoscope fluorescein angiography imaging of MAs offers the possibility of studying microvascular change on a histologic scale, which may help our understanding of disease progression and treatment response.
Etude des transitions de phase dans des composés de la famille A2MX4 : Diffusion Brilloin et propagation ultrasonore dans CS2CDBR4 (1994)

Adrenodoxin reductase is a mitochondrial flavoprotein that receives electrons from NADPH, thus initiating the electron-transport chain serving mitochondrial cytochromes P450. We have cloned and sequenced two human adrenodoxin reductase cDNAs that differ by the presence of six additional codons in the middle of one clone. The sequence in this region indicates that these six extra codons arise by alternative splicing of the pre-mRNA. Southern blot hybridization patterns of human genomic DNA cut with four restriction enzymes indicate that the human genome has only one gene for adrenodoxin reductase. Analysis of a panel of mouse-human somatic cell hybrids localized this gene to chromosome 17cen----q25. The alternatively spliced mRNA containing the six extra codons represents 10-20% of all adrenodoxin reductase mRNA. The expression of the adrenodoxin reductase gene may be stimulated by pituitary tropic hormones acting through cAMP, but its response is quantitatively much less than the responses of P450scc and adrenodoxin.
Microporous Nanocomposite Enabled Microfluidic Biochip for Cardiac Biomarker Detection (2017)

This paper demonstrates an ultrasensitive microfluidic biochip nanoengineered with microporous manganese-reduced graphene oxide nanocomposite for detection of cardiac biomarker, namely human cardiac troponin I. In this device, the troponin sensitive microfluidic electrode consisted of a thin layer of manganese-reduced graphene oxide (Mn<sub>3</sub>O<sub>4</sub>-RGO) nanocomposite material. This nanocomposite thin layer was formed on surface of a patterned indium tin oxide substrate after modification with 3-aminopropyletriethoxysilane and was assembled with a polydimethylsiloxane-based microfluidic system. The nanoengineered microelectrode was functionalized with antibodies specific to cardiac troponin I. The uniformly distributed flower-shaped nanostructured manganese oxide (nMn<sub>3</sub>O<sub>4</sub>) onto RGO nanosheets offered large surface area for enhanced loading of antibody molecules and improved electrochemical reaction at the sensor surface. This microfluidic device showed an excellent sensitivity of log [87.58] kΩ/(ng mL<sup>-1</sup>)/cm<sup>2</sup> for quantification of human cardiac troponin I (cTnI) molecules in a wide detection range of 0.008-20 ng/mL. This device was found to have high stability, high reproducibility, and minimal interference with other biomarkers cardiac troponin C and T, myoglobin, and B-type natriuretic peptide. These advantageous features of the Mn<sub>3</sub>O<sub>4</sub>-RGO nanocomposite, in conjunction with microfluidic integration, enabled a promising microfluidic biochip platform for point-of-care detection of cardiac troponin.
Microengineering of Ceramics by Direct Ink‐Jet Printing (1999)

A modified piezoelectric drop‐on‐demand ink‐jet printer was used to build 3‐D ceramic structures with cavities and overhangs by direct ceramic deposition. Inks in the form of zirconia and carbon suspensions were prepared with suitable viscosities and surface tensions. The multinozzle printer was used to microengineer small components in which support structures were created from the carbon ink and the carbon was removed after pyrolysis of the organic vehicle but before sintering the zirconia. The viability of this process is discussed in terms of machine limitations and ink drying problems.
Bragg Grating Optical Filters by UV Nanoimprinting (2012)

Results on an optical waveguide filter operating in the near IR region are reported. The device consists of a hybrid sol‐gel ‐based grating loaded waveguide, obtained through the merging of conventional photolithography and UV‐nanoimprinting. Starting from submicrometric gratings, fabricated by electron beam lithography, a soft mould has been produced and the original structures were replicated onto sol‐gel photosensitive films. A final photolithographic step allowed the production of grating‐loaded channel waveguides. The devices were optically characterized by transmission measurements in the telecom range 1450–1590 nm. The filter extinction ratio is −11 dB and the bandwidth is 1.7 nm.
Room-temperature high-sensitivity fast detector of FIR radiation (1993)

A highly sensitive fast room temperature FIR detector is proposed. The detector operation is based on intraband photoconductivity in semiconductors. It has a time resolution of 100 ps and operates in the spectral range from 50 to micrometers to 500 micrometers . Its sensitivity (at (lambda) equals 90 micrometers is 30 (mu) V/W without and 6 mV/W with a 300 MHz bandwidth amplifier) increases with wavelength as (lambda) <SUP>2</SUP>. This is at least by two orders of magnitude higher than the sensitivities of fast pyroelectric or photon drag detectors.
Supplementary Table S2 from Neoantigen Load, Antigen Presentation Machinery, and Immune Signatures Determine Prognosis in Clear Cell Renal Cell Carcinoma (2023)

&lt;p&gt;HLA-restricted neoepitopes and expression of HLA/B2M&lt;/p&gt;
54 Gbps OOK Transmission Using Single Mode VCSEL up to 1 km OM4 MMF (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text G. Stepniak, J. -. Kropp, N. N. Ledentsov, V. A. Shchukin, N. Ledentsov, G. Schaefer, and J. P. Turkiewicz, "54 Gbps OOK Transmission Using Single Mode VCSEL up to 1 km OM4 MMF," in Optical Fiber Communication Conference, OSA Technical Digest (online) (Optica Publishing Group, 2016), paper Th4D.5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Design Tradeoffs for BLAS Operations on Reconfigurable Hardware (2005)

Numerical linear algebra operations are key primitives in scientific computing. Performance optimizations of such operations have been extensively investigated and some basic operations have been implemented as software libraries. With the rapid advances in technology, hardware acceleration of linear algebra applications using FPGAs (field programmable gate arrays) has become feasible. In this paper, we propose FPGA-based designs for several BLAS operations, including vector product, matrix-vector multiply, and matrix multiply. By identifying the design parameters for each BLAS operation, we analyze the design tradeoffs. In the implementations of the designs, the values of the design parameters are determined according to the hardware constraints, such as the available area, the size of on-chip memory, the external memory bandwidth and the number of I/O pins. The proposed designs are implemented on a Xilinx Virtex-II Pro FPGA.