522 EXPRESSION OF ANDROGEN AND ESTROGEN RECEPTORS AND ITS PROGNOSTIC SIGNIFICANCE IN HIGH-GRADE UROTHELIAL CARCINOMA OF THE BLADDER (2011)

You have accessJournal of UrologyBladder Cancer: Basic Research1 Apr 2011522 EXPRESSION OF ANDROGEN AND ESTROGEN RECEPTORS AND ITS PROGNOSTIC SIGNIFICANCE IN HIGH-GRADE UROTHELIAL CARCINOMA OF THE BLADDER Hiroshi Miyamoto, Jorge Yao, Yichun Zheng, Iawan Hsu, Koji Izumi, George Netto, Edward Messing, Chawnshang Chang, and Shuyuan Yeh Hiroshi MiyamotoHiroshi Miyamoto Rochester, NY , Jorge YaoJorge Yao Rochester, NY , Yichun ZhengYichun Zheng Rochester, NY , Iawan HsuIawan Hsu Rochester, NY , Koji IzumiKoji Izumi Rochester, NY , George NettoGeorge Netto Baltimore, MD , Edward MessingEdward Messing Rochester, NY , Chawnshang ChangChawnshang Chang Rochester, NY , and Shuyuan YehShuyuan Yeh Rochester, NY View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1218AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Men have a significantly higher risk of bladder cancer than women, whereas the prognosis of men with bladder cancer is better than that of women. Steroid hormone receptor signals have been shown to involve bladder carcinogenesis and cancer progression. Although there are several reports showing the expression of androgen receptor (AR) and estrogen receptors (ERs) in bladder cancer, which could correlate with tumor grade and stage, its prognostic significance remains unclear. METHODS We investigated the expression of AR and ERα in 59 high-grade urothelial carcinomas of the bladder by immunohistochemistry. We then evaluated the correlations of their expression with clinicopathologic features available for our patient cohort. RESULTS AR and ER stain positively in 25 (42%) and 27 (46%) carcinoma tissues, respectively, which was lower than in corresponding benign urothelium [AR-positive in 50 (85%) cases (p<0.0001) and ER-positive in 34 (58%) cases (p=0.2690)] and in stroma that underlies benign urothelium [AR-positive in 39 (66%) cases (p=0.0159) and ER-positive in 41 (70%) cases (p=0.0151)]. There were no statistically significant correlations between each staining and gender of the patients, muscle invasion (≤T1 vs. ≥T2), or lymph node metastasis. Status of AR expression was not strongly associated with that of ER (p=0.1975). Metastatic carcinomas in the lymph node were additionally stained for AR [10 of 14 (71%), including 3 tumors in which primary carcinoma was AR-negative] and ER [9 of 14 (64%), including 2 tumors in which primary carcinoma was ER-negative]. Kaplan-Meier and log-rank tests further revealed that positivity of AR (p=0.0775) or ER (p=0.0603) was tended to correlate with tumor progression. Interestingly, patients with AR-positive/ER-positive tumor had a significantly higher risk of progression, compared to those with AR-negative/ER-negative tumor (p=0.0177) or AR-negative and/or ER-negative tumor (p=0.0077). CONCLUSIONS Significant decreases in the expression of AR or ER in bladder cancer were seen, compared to that in non-neoplastic bladder. Although the expression of AR or ER had no significant impact on histopathological characteristics, loss of AR, ER, or both was strongly associated with better prognosis among patients with high-grade urothelial carcinoma. Our results may enhance previous findings suggesting the involvement of the AR/ER pathways in bladder cancer progression. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e212 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Hiroshi Miyamoto Rochester, NY More articles by this author Jorge Yao Rochester, NY More articles by this author Yichun Zheng Rochester, NY More articles by this author Iawan Hsu Rochester, NY More articles by this author Koji Izumi Rochester, NY More articles by this author George Netto Baltimore, MD More articles by this author Edward Messing Rochester, NY More articles by this author Chawnshang Chang Rochester, NY More articles by this author Shuyuan Yeh Rochester, NY More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...