gebhart/patrepeval huggingface dataset:
Red blood cell transfusions and tissue oxygenation in anemic hematology outpatients (2011)

Although anemia in chronically anemic hematology outpatients was not associated with low StO(2) and THI levels, RBC transfusions were successful in improving these variables.
Potency of descending pain modulatory system is linked with peripheral sensory dysfunction in fibromyalgia (2019)

Fibromyalgia (FM) is characterized by chronic widespread pain whose pathophysiological mechanism is related to central and peripheral nervous system dysfunction. Neuropathy of small nerve fibers has been implicated due to related pain descriptors, psychophysical pain, and neurophysiological testing, as well as skin biopsy studies. Nevertheless, this alteration alone has not been previously associated to the dysfunction in the descending pain modulatory system (DPMS) that is observed in FM. We hypothesize that they associated, thus, we conducted a cross-sectional exploratory study.To explore small fiber dysfunction using quantitative sensory testing (QST) is associated with the DPMS and other surrogates of nociceptive pathways alterations in FM.We run a cross-sectional study and recruited 41 women with FM, and 28 healthy female volunteers. We used the QST to measure the thermal heat threshold (HTT), heat pain threshold (HPT), heat pain tolerance (HPT), heat pain tolerance (HPTo), and conditional pain modulation task (CPM-task). Algometry was used to determine the pain pressure threshold (PPT). Scales to assess catastrophizing, anxiety, depression, and sleep disturbances were also applied. Serum brain-derived neurotrophic factor (BDNF) was measured as a marker of neuroplasticity. We run multivariate linear regression models by group to study their relationships.Samples differed in their psychophysical profile, where FM presented lower sensitivity and pain thresholds. In FM but not in the healthy subjects, regression models revealed that serum BDNF was related to HTT and CPM-Task (Hotelling Trace = 1.80, P < .001, power = 0.94, R = 0.64). HTT was directly related to CPM-Task (B = 0.98, P = .004, partial-η = 0.25), and to HPT (B = 1.61, P = .008, partial η = 0.21), but not to PPT. Meanwhile, BDNF relationship to CPM-Task was inverse (B = -0.04, P = .043, partial-η = 0.12), and to HPT was direct (B = -0.08, P = .03, partial-η = 0.14).These findings high spot that in FM the disinhibition of the DPMS is positively correlated with the dysfunction in peripheral sensory neurons assessed by QST and conversely with serum BDNF.
Enteropathogenic Escherichia coli (EPEC) expressing a non-functional bundle-forming pili (BFP) also leads to increased growth failure and intestinal inflammation in C57BL/6 mice (2022)

Bundle-forming pili (BFP) are implicated in the virulence of typical enteropathogenic E. coli (EPEC), resulting in enhanced colonization and mild to severe disease outcomes; hence, non-functional BFP may have a major influence on disease outcomes in vivo. Weaned antibiotic pre-treated C57BL/6 mice were orally infected with EPEC strain UMD901 (E2348/69 bfpA C129S); mice were monitored daily for body weight; stool specimens were collected daily; and intestinal tissues were collected at the termination of the experiment on day 3 post-infection. Real-time PCR was used to quantify fecal shedding and tissue burden. Intestinal inflammatory biomarkers lipocalin-2 (LCN-2) and myeloperoxidase (MPO) were also assessed. Infection caused substantial body weight loss, bloody diarrhea, and intestinal colonization with fecal and intestinal tissue inflammatory biomarkers that were comparable to those previously published with the wild-type typical EPEC strain. Here we further report on the evaluation of an EPEC infection model, showing how disruption of bfp function does not impair, and may even worsen diarrhea, colonization, and intestinal disruption and inflammation. More research is needed to understand the role of bfp in pathogenicity of EPEC infections in vivo.
Los MOOC un desafío para latinoamérica (2023)

Internet2, las NREN como la red Clara, Innova-Red, REUNA, RNP etc., y la Web 2.0 conceden una plataforma excelente para desarrollar nuevas herramientas aplicadas al aprendizaje, por otro lado los MOOC, enseñanza en formato de curso abierto y masivo en línea, y los nuevos paradigmas educativos utilizando redes sociales y videos otorgan herramientas básicas para la formación actual. En América Latina, se observa que la matrícula anual de las universidades se ve afectada por una importante deserción, debido a factores de índole social y económicos. Con la intención de atender a éste grave problema a través de la utilización de la infraestructura tecnológica existente, desarrollamos una breve experiencia llevada a cabo en la Universidad Nacional de Córdoba, con la intención de mostrar una alternativa, y abrir el debate hacia una búsqueda interdisciplinaria y colaborativa de soluciones.
Destillative Diastereomerentrennung ‐ ein neues Verfahren zur Darstellung von optisch aktiven heterocyclischen Carbonsäuren (1993)

Eine Racematspaltung durch Destillation läßt sich ‐ im Gegensatz zur klassischen Racematspaltung durch Kristallisation ‐ leicht durchführen. Dazu werden im Falle der Carbonsäuren 1 (X = O, S und n = 1, 2) die diastereomeren Säureamide 2 , deren Vakuumsiedepunkte sich um bis zu 7 K unterscheiden, eingesetzt. So konnten beispielsweise beide Enantiomere von 2‐Tetrahydrofurancarbonsäure 1a (X = O, n = 1) über eine destillative Trennung der Diastereomere von 2a (R = i Pr, R′ = Me) in jeweils 99% optischer Reinheit erhalten werden. magnified image
InP-InGaAsP wafer-bonded vertically coupled X-crossing multiple channel optical add-drop multiplexer (2001)

A vertically coupled InP-InGaAsP crossed waveguide optical add-drop multiplexer has been realized through the use of wafer bonding. Designed for signals in the 1550-nm range, this novel device requires only a single epitaxial growth and illustrates the use of vertical optical interconnects for the three dimensional routing of optical signals. To our knowledge, it is also one of the first optical vertically coupled devices with no horizontally coupled counterpart.
Bevacizumab therapy for POEMS syndrome (2005)

The role of vascular endothelial growth factor (VEGF) in hematologic malignancies was recently reviewed in this journal.[1][1] Serum VEGF is higher in POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) patients than other monoclonal gammopathies and is
Endothelium-mediated regulation of coronary tone (1991)

To what extent endothelial autacoids like endothelium-derived relaxant factor/nitric oxide (EDRF/NO), in addition to neural-humoral factors, are involved in the regulation of myocardial perfusion, is presently not known. Therefore, we investigated in conscious, chronically instrumented dogs the effect of stereospecific inhibitors (NG-monomethyl-L-arginine (L-NMMA), NG-nitro-L-arginine (L-NNA), NG-monomethylester-L-arginine (L-NAME] of nitric oxide-synthesis and -release on epicardial coronary tone (and coronary diameter) and myocardial perfusion. A hydraulic coronary cuff was used, to produce reactive hyperemia and to keep the myocardial perfusion constant over short periods. 40 mg/kg L-NNA i.v. caused a long-lasting increase in mean arterial blood pressure from 94 +/- 8 to 129 +/- 11 mmHg and a simultaneous decrease in coronary diameter by 2.8 +/- 0.3%. Heart rate dropped from 87 to 58 min-1, but the double product of heart rate and blood pressure dropped by only 8 +/- 2% (p = 0.05). The maximal coronary conductance during peak reactive hyperemia (after 20 s ischemia) indicating complete coronary dilation was diminished by 48% after L-NNA. The severe drop in resting myocardial perfusion and O2-supply, and nearly unchanged rate pressure product and thus myocardial metabolic rate following the inhibition of nitric oxide formation demonstrate a substantial contribution of EDRF/NO to the regulation of myocardial perfusion.
High-Gain Low-Divergence OAM Antenna (2019)

The practical application of the Orbital Angular Momentum (OAM) antenna is limited by its valid transmission distance which affected by the gain and the divergence of OAM beams. Open resonator antenna (ORA) can realize a high gain and low divergence OAM radiation by exciting two HE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">21</sub> modes inside. The proposed antenna consists of a spherical ground and a partially reflective surface (PRS) and is fed by slot-coupled patches. A 14-dBi gain OAM beam (l = ±2) with its maximum directivity in ± 9° can be achieved at 13 GHz by this structure.
Hybrid Watch User Interfaces (2018)

We introduce programmable material and electromechanical control to enable a set of hybrid watch user interfaces that symbiotically leverage the joint strengths of electro-mechanical hands and a dynamic watch dial. This approach enables computation and connectivity with existing materials to preserve the inherent physical qualities and abilities of traditional analog watches.
S113 An Epidemiological Review of Strains of Pseudomonas aeruginosa in a Non-Cystic Fibrosis Bronchiectasis Cohort (2015)

<h3>Introduction and objectives</h3> <i>Pseudomonas aeruginosa</i> (<i>Pa</i>) is a significant respiratory pathogen. Research in Cystic Fibrosis cohorts has revealed transmissible strains, leading to heightened infection control protocols due to concerns of cross-infection. In patients with Non-Cystic Fibrosis Bronchiectasis (NCFB), the research is more limited. Our objectives were to investigate the strains found in our local NCFB population, and assess the occurrence of shared strains. <h3>Methods</h3> Patients with NCFB and previous <i>Pa</i> in sputum culture consented to providing sputum for the study and review of their medical notes. Sputum samples from patients were processed in the usual manner and if <i>Pa</i> was isolated, 10 representative colonies per patient were stored for strain typing. Isolates were subjected to Random Amplification of Polymorphic DNA (RAPD). Distinct RAPD types were verified by electrophoresis on an Agilent Bioanalyzer and subsequent cluster analysis using GelCompar II software, and further investigated by Multi-Locus Sequence Typing (MLST). <h3>Results</h3> <i>Pa</i> was obtained from 46 patients over 12 months providing 459 isolates. Co-existence of multiple strains was observed in two patients. Twenty patients (43%) had unique strains by RAPD and the remaining patients were clustered into 7 subgroups, defined as ≥90% homology by RAPD, using Pearson’s correlation analysis. The largest cluster showed a predominance of one MLST strain type identified as ST-17 (also known as “Clone C”) on the MLST database. In our cohort, 8 patients (17%) harboured Clone C, which is a higher prevalence than observed in previous UK studies of various patient cohorts (typically 2–6% prevalence). MLST analysis of smaller RAPD clusters identified other MLST strain types shared by 2 or 3 patients. As with Clone C, all the observed shared MLST strain types are globally distributed. MLST did not reveal any novel shared strains. <h3>Conclusions</h3> Our cohort of patients with NCFB shows evidence of shared strains of <i>Pa</i> including a high prevalence of Clone C compared to previous national reports. Whilst the occurrence of shared strains may reflect their global distribution, we cannot rule out cross-infection between patients.
Strong, Tough, Electrospun Polymer–Nanotube Composite Membranes with Extremely Low Density (2008)

Abstract Electrospinning has been used to produce porous, low density, polymer–nanotube composite membranes. The membrane mechanical properties can be enhanced by tuning the nanotube content, aligning the fibers during spinning, and by post production drawing. The mechanical properties are maximized for membranes with a nanotube content of 0.43 vol %. Aligned composites at this volume fraction have been prepared by spinning onto a rotating drum collector electrode. This method results in significant increases in modulus, strength, and toughness. The best composites, produced at the maximum drum rotation rate, were post treated by a drawing step to result in further increases in modulus and strength. These methods allows the production of membranes with densities as low as ∼340 kg m −3 but with values of stiffness, strengths and toughness's more typically found in bulk thermoplastics; 1.2 GPa, 40 MPa, and 13 J g −1 .
X-ray CT Scans - Bats - Set 4 (2020)

A collection of x-ray computed tomography scans of specimens from the Museum of Southwestern Biology.
Angiopoietin 2 Is a Potential Mediator of High-Dose Interleukin 2–Induced Vascular Leak (2007)

Ang2 may be a mediator of HDIL2 VLS as evidenced by (a) an increase in Ang2 in all patients on HDIL2; (b) the effect of high Ang2 patient serum on cultured endothelial cells; (c) rescue of those structural changes by Ang1. The lack of correlation between VLS and serum VEGF levels in patients treated with HDIL2 alone or in combination with bevacizumab suggests that VEGF is not a major contributor to VLS or Ang2 release. These data suggest that the inhibition of Ang2 may mitigate VLS in patients receiving HDIL2.
Assuring the safety of AI-based clinical decision support systems: a case study of the AI Clinician for sepsis treatment (2022)

These advances provide a use case for the systematic safety assurance of AI-based clinical systems towards the generation of explicit safety evidence, which could be replicated for other AI applications or other clinical contexts, and inform medical device regulatory bodies.
Second-Stage Reimplantation of a Total Knee Prosthesis Complicated by Infection (2003)

Corresponding author (letter): Robert Atkins, FRACS, 135 Hutt Street, Adelaide, 5000, Australia, [email protected] Corresponding author (reply): Dana C. Covey, MD, Captain, Medical Corps, United States Navy, Department of Orthopaedic Surgery, United States Naval Hospital, Okinawa PSC 482, Box 2563, FPO AP 96362-2563
Posterior Cruciate and Posterolateral Ligament Reconstruction in an Adolescent with Open Physes (2007)

1 Tennessee Orthopaedic Alliance, 4230 Harding Road, Suite 1000, Nashville, TN 37205. E-mail address for A.F. Anderson: [email protected]
West Antarctic archipelago covered by cool-temperate forests during early Oligocene glaciation (2021)

&amp;lt;p&amp;gt;The Eocene-Oligocene Transition (~34.4&amp;amp;#8211;33.7 Ma) marks a major step in the long-term evolution from the greenhouse climate of the Early Palaeogene to the icehouse regime of the Late Neogene and Quaternary. However, it remains uncertain which landmasses were covered by ice sheets during the Early Oligocene Glacial Maximum (~33.7&amp;amp;#8211;33.2 Ma), an interval of peak glaciation inferred from deep-sea benthic foraminifera oxygen isotope records that immediately follows the Eocene-Oligocene Transition. The scarcity of Late Eocene and Early Oligocene continental and shallow-marine records in both Arctic and Antarctic regions has prevented the reconstruction of environmental conditions and ice-sheet extent during the Early Oligocene, which is critical for assessing ice&amp;amp;#8211;ocean&amp;amp;#8211;atmosphere interactions during early stages of the Cenozoic icehouse. Here, we present the first Early Oligocene shallow-marine record from the Pacific margin of West Antarctica, recovered from the central Amundsen Sea Embayment shelf on RV&amp;amp;#160;&amp;lt;em&amp;gt;Polarstern&amp;lt;/em&amp;gt; expedition PS104 at Site 21. Marine mudstones recovered at this site document the presence of a vegetated archipelago at a palaeo-latitude of 73.5&amp;amp;#176;S. Pollen assemblages and organic biomarker proxies indicate a cool-temperate&amp;amp;#160;&amp;lt;em&amp;gt;Nothofagus&amp;lt;/em&amp;gt;-dominated forest situated within a productive marine archipelago. No evidence for marine terminating ice was detected in the cores from Site 21, thus indicating that the West Antarctic Ice Sheet was small or entirely absent during the Early Oligocene.&amp;lt;/p&amp;gt;
Characterization of Immunosuppressive Substances in the Basic Protein Fraction of Uterine Secretions from Pregnant Ewes1 (1987)

The basic protein fraction of ovine uterine secretions collected late in pregnancy (Days 125-140) contains a substance capable of inhibiting in vitro blastogenic responses of lymphocytes to phytohemagglutinin (PHA) or mixed lymphocyte reactions. In this study, the immunosuppressive substance in the basic protein fraction of uterine secretions was further defined by gel filtration. The immunosuppressive activity resided in a group of high molecular weight proteins eluting at the void volume of Sephacryl S-200 and Sepharose CL-6B columns. For example, incorporation of thymidine by PHA-stimulated lymphocytes incubated with 20, 40, 80, and 120 micrograms/ml of protein from the void volume of Sepharose CL-6B was 65, 28, 2, and 0 percent of control lymphocytes, respectively. Based on polyacrylamide-gel electrophoresis in the presence of sodium dodeylsulfate (SDS), the immunosuppressive fraction from Sepharose CL-6B chromatography contained aggregates of uterine milk proteins (UTM-proteins) and a pair of proteins running at the top of a 5% (w/v) polyacrylamide gel. Other protein peaks resolved by Sephacryl S-200 and Sepharose CL-6B contained aggregates of UTM-proteins but were not immunosuppressive. The substance inhibiting in vitro lymphocyte function was not of conceptus origin, because it was found in fluid from the ligated uterine horn of unilaterally pregnant ewes and from the uterus of an ovariectomized ewe treated for 60 days with progesterone and estrone.
An IoT-Based Healthcare Platform for Patients in ICU Beds During the COVID-19 Outbreak (2021)

There is a global concern with the escalating number of patients at hospitals caused mainly by population aging, chronic diseases, and recently by the COVID-19 outbreak. To smooth this challenge, IoT emerges as an encouraging paradigm because it provides the scalability required for this purpose, supporting continuous and reliable health monitoring on a global scale. Based on this context, an IoT-based healthcare platform to provide remote monitoring for patients in a critical situation was proposed in the authors' previous works. Therefore, this paper aims to extend the platform by integrating wearable and unobtrusive sensors to monitor patients with coronavirus disease. Furthermore, we report a real deployment of our approach in an intensive care unit for COVID-19 patients in Brazil.
Superconducting Switch for Fast On-Chip Routing of Quantum Microwave Fields (2016)

For a quantum computer, switching a signal carried by single microwave photons is desirable in scaling up superconducting circuitry. The authors design and build such a switch, integrate it on a chip with a single-photon source, and prove that it works with nonclassical microwave input. Their device offers negligible heating, relatively large bandwidth, low nonlinearity, and single-pole double-throw switching in mere nanoseconds. It is well suited for applications where signal routing must be controlled by real-time feedback, as in multiplexing qubit control and readout, or distributing entanglement in quantum networks.
Use of the Daily Phone Diary to Study Religiosity and Mood: Convergent Validity (2016)

Studies of religious/spiritual behavior frequently rely on self-reported questionnaire data, which is susceptible to bias. The Daily Phone Diary (DPD) was developed to minimize bias in reporting activities and behavior across a 24-hour period. A cross-sectional study of 126 parents of children with cystic fibrosis was used to establish the validity of the DPD to study religious/spiritual behaviors. Longitudinal models were used to determine the odds of improved mood during religious/spiritual activities. Convergent validity was found. Participants had increased odds of improved mood during religious/spiritual activities compared to nonreligious/spiritual activities. Associations with gender and religious affiliations were found. The DPD is a valid tool for studying religious/spiritual activities and opens novel avenues for chaplaincy research and the development of chaplaincy interventions incorporating these findings.
RESISTANCE OF POIKLLOTHERMIC ANIMALS TO COLD (1961)

Journal Article RESISTANCE OF POIKLLOTHERMIC ANIMALS TO COLD Get access A. W. SALT, Ph.D. A. W. SALT, Ph.D. Canada Agriculture Research Station LethbridgeAlberta, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar British Medical Bulletin, Volume 17, Issue 1, January 1961, Pages 5–8, https://doi.org/10.1093/oxfordjournals.bmb.a069864 Published: 01 January 1961
Ion-selective membranes and electrodes (2015)

AccessScience is an authoritative and dynamic online resource that contains incisively written, high-quality educational material covering all major scientific disciplines. An acclaimed gateway to scientific knowledge, AccessScience is continually expanding the ways it can demonstrate and explain core, trustworthy scientific information that inspires and guides users to deeper knowledge.
3-(4-Bromobenzyl)-5-(4-fluorobenzylidene)imidazolidine-2,4-dione (1995)

The imidazolidinedione and fluorobenzylidene rings in the title compound, C 17 H 12 BrFN 2 O 2 , are coplanar ; the dihedral angle between this plane and the plane of the substituted bromobenzyl ring is 104.9(2)°. The molecules in the crystal are held together by hydrogen bonds and van der Waals interactions.
Computed tomography to identify risk factors for left circumflex artery injury during mitral surgery (2021)

The anatomical relationship between the LCX and the mitral annulus can be recognized using superimposed 3D-CT images. This approach is useful to avoid LCX injury in mitral valve surgery since the X point varies between patients.
Stereochemistry and the Mechanism of Hydrogenation of Cycloölefins on a Platinum Catalyst1,2 (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemistry and the Mechanism of Hydrogenation of Cycloölefins on a Platinum Catalyst1,2Samuel Siegel and Gerard V. SmithCite this: J. Am. Chem. Soc. 1960, 82, 23, 6082–6087Publication Date (Print):December 1, 1960Publication History Published online1 May 2002Published inissue 1 December 1960https://pubs.acs.org/doi/10.1021/ja01508a027https://doi.org/10.1021/ja01508a027research-articleACS PublicationsRequest reuse permissionsArticle Views724Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts