gebhart/patrepeval huggingface dataset:
Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice (2012)

Heme oxygenase (HO) system is one of the key regulators of cellular redox homeostasis which responds to oxidative stress (ROS) via HO-1 induction. However, recent reports have suggested an inhibitory effect of ROS on HO activity. In light of these conflicting reports, this study was designed to evaluate effects of chronic oxidative stress on HO system and its role in contributing towards patho-physiological abnormalities observed in extracellular superoxide dismutase (EC-SOD, SOD3) KO animals. Experiments were performed in WT and EC-SOD((-/-)) mice treated with and without HO inducer, cobalt protoporphyrin (CoPP). EC-SOD((-/-)) mice exhibited oxidative stress, renal histopathological abnormalities, elevated blood pressure, impaired endothelial function, reduced p-eNOS, p-AKT and increased HO-1 expression; although, HO activity was significantly (P < 0.05) attenuated along with attenuation of serum adiponectin and vascular epoxide levels (P < 0.05). CoPP, in EC-SOD((-/-)) mice, enhanced HO activity (P < 0.05) and reversed aforementioned pathophysiological abnormalities along with restoration of vascular EET, p-eNOS, p-AKT and serum adiponectin levels in these animals. Taken together our results implicate a causative role of insufficient activation of heme-HO-adiponectin system in pathophysiological abnormalities observed in animal models of chronic oxidative stress such as EC-SOD((-/-)) mice.
Can we beat the biotin–avidin pair?: cucurbit[7]uril-based ultrahigh affinity host–guest complexes and their applications (2015)

The design of synthetic, monovalent host-guest molecular recognition pairs is still challenging and of particular interest to inquire into the limits of the affinity that can be achieved with designed systems. In this regard, cucurbit[7]uril (CB[7]), an important member of the host family cucurbit[n]uril (CB[n], n = 5-8, 10, 14), has attracted much attention because of its ability to form ultra-stable complexes with multiple guests. The strong hydrophobic effect between the host cavity and guests, ion-dipole and dipole-dipole interactions of guests with CB portals helps in cooperative and multiple noncovalent interactions that are essential for realizing such strong complexations. These highly selective, strong yet dynamic interactions can be exploited in many applications including affinity chromatography, biomolecule immobilization, protein isolation, biological catalysis, and sensor technologies. In this review, we summarize the progress in the development of high affinity guests for CB[7], factors affecting the stability of complexes, theoretical insights, and the utility of these high affinity pairs in different challenging applications.
Dental Implant Clinical Research Group Three-Year Progress Report (1994)

Stoffer, W; Morris, H F; Ochi, S; Weir, D J; Lauciello, F; Lambert, P; Gillette, W; Glasscock, W Author Information
Electrical properties of the(V1−xCrx)2O3system (1980)

Extensive electrical resistivity and Seebeck-coefficient measurements are reported for ${({\mathrm{V}}_{1\ensuremath{-}x}{\mathrm{Cr}}_{x})}_{2}{\mathrm{O}}_{3}$ single-crystal alloys in the range $0\ensuremath{\le}x\ensuremath{\le}0.1$. For $0\ensuremath{\le}x\ensuremath{\le}0.005$ a metal-insulator transition is encountered at 150-170 K which coincides with the onset of antiferromagnetic ordering. Above room temperature there is a gradual transition to a second metallic phase. The resistivity of the metallic phase at a fixed temperature increases by three orders of magnitude on changing the Cr content from 0 to 1.8 at.%, while the Seebeck coefficient remains virtually unaltered. For fixed alloy composition $0.005&lt;x&lt;0.018$, increasing temperature produces three transitions: The alloy is an antiferromagnetic insulator (AFI) at low temperatures, a metal ($M$) at intermediate temperatures, a paramagnetic insulator ($I$) at higher temperature, and then reverts back to a quasimetallic state (${M}^{\ensuremath{'}}$) at elevated temperatures. The $M\ensuremath{-}I$ transformation is accompanied by unusually large hysteresis effects. For $0.018\ensuremath{\le}x\ensuremath{\le}0.1$ only the AFI, $I$, and ${M}^{\ensuremath{'}}$ phases are encountered. These findings can be accounted for in a semiempirical manner in terms of a Fermi level for the $M$ phase that intersects a local minimum in the density of states, which deepens further and ultimately gives rise to a band gap, either as $x$ is increased past the critical value of 0.0177 at fixed temperature $T$, or as $T$ is changed at constant $x$. The band gap, generated when the $I$ phase appears, is probably due to a Hubbard-type transition that is strongly affected by electron-phonon interactions; it then closes self-consistently with a further increase in $T$. The band gap obtained on cooling is associated with the onset of antiferromagnetic ordering. The generally accepted phase diagram for the system has been amended to include the existence above 450 K of another phase (${M}^{\ensuremath{'}}$) which is either a metal or a highly degenerate semiconductor.
Schematic representation of the embryonic phenotype induced by the lack of PrP and Shadoo. (2015)

&lt;p&gt;The lethal consequence of the absence of PrP and Shadoo during early mouse embryogenesis is indicated.&lt;/p&gt;
ChemInform Abstract: QUENCHING OF THE LUMINESCENT STATE OF URANIUM IN OXIDES BY METAL IONS (1977)

Abstract Der Einfluß einiger Fremdionen auf die Lumineszenz des 6wertigen Urans in der geordneten Perowskitstruktur wird an Proben der allgemeinen Zusammensetzung Ba2Mg1‐xMx‐ W0,997U0,003O6 (M: Mn, Co, Cu, Ni) und BauPb0,3MgWo,99‐,U0,o03O6 untersucht.
Modifications of membrane lipid structure and their influence on cell growth, passive permeability, and enzymatic and transport activities in Acholeplasma laidlawii B (1986)

Acholeplasma laidlawii B is a simple procaryotic microorganism, without a cell wall, whose membrane lipid fatty acid composition and cholesterol content can be dramatically modified. It is thus possible to markedly vary the temperature and cooperativity of the gel to lipid-crystalline phase transition, thereby altering the phase state and "fluidity" of the A. laidlawii membrane lipids. By varying the chain length of the exogenous fatty acids supplied, it is also possible to modify the thickness of the membrane lipid bilayer. Acholeplasma laidlawii B cell growth and most membrane functions are strongly dependent on the phase state of the membrane lipids. When gel-state lipid predominates at physiological temperatures, cell growth declines sharply, nonelectrolyte permeability exhibits a pronounced local maximum, net glucose transport is markedly reduced, and ATPase activity declines moderately. Upon complete conversion of the lipid to the gel state, cell growth ceases, passive permeability is markedly reduced, and net glucose transport is abolished, but appreciable ATPase activity remains. Provided that the membrane lipid is predominantly or exclusively in the liquid-crystalline state, cell growth and ATPase activity are almost independent of membrane lipid fatty acid composition and cholesterol content, except that cell growth is inhibited by the presence of "hyperfluid" lipid. In contrast, passive permeability and active glucose uptake are influenced by alterations in membrane lipid composition, with increases in lipid fluidity resulting in higher nonelectrolyte translocation rates. Alterations in the length of the membrane lipid hydrocarbon chains per se also appear to affect A. laidlawii growth and membrane function. Thus lipids containing fatty acids with effective chain lengths of 13 carbons or less do not support cell growth or normal enzymatic and transport activities, and lipids with effective hydrocarbon chain lengths of 19 carbons or more do not support normal cell growth.
The Influence of Curing Periods on the Compressive Strength of Fly Ash-Based Geopolymer at Different Aging Times (2012)

Omar A. Abdulkareem1a, A.M. Mustafa Al Bakri1b, H. Kamarudin1c, and I. Khairul Nizar2d 1Center of Excellence Geopolymer System Research, School of Material Engineering, Universiti Malaysia Perlis (UniMAP), P.O. Box 77, D/A Pejabat Pos Besar, Kangar, Perlis, 01000, Malaysia. 2School of Environmental Engineering, Universiti Malaysia Perlis (UniMAP), Box 77, D/A Pejabat Pos Besar, Kangar, Perlis, 01000, Malaysia. aeng.omar83@yahoo.com,bmustafa_albakri@unimap.edu.my, cvc@unimap.edu.my, dnizar@unimap.edu.my. Keywords: curing periods, geopolymerization, alkaline activator, compressive strength, fly ash.
Atomic processes during Cl supersaturation etching ofSi(100)−(2×1) (2009)

Supersaturation etching starts with Cl insertion into Si-Si bonds of Si(100) and leads to the desorption of ${\text{SiCl}}_{2}$ pairs. During etching, insertion occurs through a ${\text{Cl}}_{2}$ dissociative chemisorption process mediated by single dangling bond sites created by phonon-activated electron-stimulated desorption of atomic Cl. Based on scanning tunneling microscopy results, we identify a surface species, describe its involvement in supersaturation etching, and explore the energetics that control this process. In doing so, we show that insertion occurs at room temperature and that paired dangling bonds of bare dimers also mediate this process.
Hardware configuration framework for the IBM eServer z900 (2002)

This paper describes the concept, architecture, and implementation of the hardware configuration module within the support element of the IBM eServer z900. For the z900 project, this base system firmware component has been redesigned to obtain a software structure with a clear, simple, and scalable architecture that is suitable for future extensions to the z900. To achieve the desired flexibility, an object-oriented framework has been developed which supports the auto-sensing and configuration of hardware components as well as their status representation and management. The new configuration concept is based on a rule approach in which, for each sensed physical part in the system, a configuration rule specifies the object hierarchy to be instantiated upon it, including attributes and interconnections to other system parts. Furthermore, the concept and architecture of the framework are built upon a hardware object model (HOM) that has been designed to allow for further integration of key business logic of the z900 service subsystem and hardware support code.
Link capacity allocation and network control by filtered input rate in high-speed networks (1995)

We study link capacity allocation for a finite buffer system to transmit multimedia traffic. The queueing process is simulated with real video traffic. Two key concepts are explored in this study. First, the link capacity requirement at each node is essentially captured by its low-frequency input traffic (filtered at a properly selected cut-off frequency). Second, the low-frequency traffic stays intact as it travels through a finite-buffer system without significant loss. Hence, one may overlook the queueing process at each node for network-wide traffic flow in the low-frequency band. We propose a simple, effective method for link capacity allocation and network control using on-line observation of traffic flow in the low-frequency band. The study explores a new direction for measurement-based traffic control in high-speed networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Enhanced energy storage density in lead free (Na0.5Bi0.48Eu0.02)Ti1-xNbxO3(x=0.00, 0.01 & 0.02) ceramics (2018)

Eco friendly (Na0.5Bi0.48Eu0.02) Ti1-xNbxO3 ceramics were synthesized with help of conventional solid state reaction by using high energy ball milling. The room temperature XRD of Nb5+ substituted NBET ceramics were stabilized in single phase pervoskite structure without any secondary phase. Polarization study reflects long range ferroelectric order for pure NBET ceramics and coercive field enhance with the substitution of Nb5+ ion at Ti site. Further, the substitution of Nb5+ ≥ 0.02 composition induced relaxor future. The energy density calculation shows the maximum energy storage density of 1.02 J/cm3 for x=0.02 ceramics. These results confirms a small fraction of Nb5+ doped NBET ceramics should be good candidates for energy storage applications.
Trustworthy tools for trustworthy programs: a mechanically verified verification condition generator for the total correctness of procedures (1996)

of the Dissertation Verification Condition Generator verification conditions Trustworthy Tools for Trustworthy Programs: A Mechanically Verified Verification Condition Generator for the Total Correctness of Procedures by Doctor of Philosophy in Computer Science University of California, Los Angeles, 1995 Professor David F. Martin, Chair As an alternative to testing, formal proofs of a program&amp;apos;s correctness may be constructed. The application of these techniques has been limited by the difficulty of constructing the required proofs by hand. The task of proving a program correct can be simplified and eased by a tool called a (VCG), which automatically constructs a significant portion of the proof. The VCG processes programs written in the specified language, and produces as its result a set of lemmas called , as the remainder left for the programmer to prove. The truth of these is intended to imply the correctness of the program. However, most VCGs that have been written have ...
Length and loss of heterozygosity of an intron 1 polymorphic sequence of egfr is related to cytogenetic alterations and epithelial growth factor receptor expression. (2000)

Overexpression of epithelial growth factor receptor (EGFR) is correlated with a poor prognosis and reduced steroid receptor expression. Recently, it was demonstrated that the length of a CA repeat in the intron 1 of EGFR correlated with the expression of EGFR in vitro. We investigated 112 cases of cancerous and noncancerous breast tumor samples for loss of heterozygosity (LOH) in intron 1 of the egfr gene and determined the intratumoral EGFR content and genetic alterations by comparative genomic hybridization. Heterozygous tumors with short CA repeats showed elevated EGFR expression in contrast to tumors with longer CA repeats. Tumors with LOH in intron 1 of egfr revealed higher EGFR expression when the longer allele was lost compared with loss of the shorter allele. Additionally, tumors with a loss of the long allele showed more chromosomal alterations, especially a higher frequency of amplifications. We conclude that the CA repeat status in intron 1 of the egfr gene also modulates the intratumoral EGFR content in vivo. Furthermore, LOH at the CA repeat is associated with genetically advanced tumors. Therefore, allele-specific gene expression due to LOH of the CA repeat could be assumed to be an important event in invasive breast cancer development.
User-definable Medication Favorites for an Outpatient Electronic Medical Record System (2001)

Use of a medication favorites list can decrease computerized online prescribing time significantly. We have implemented a medication favorites feature that allows users to create their own list of frequently used medication orders to facilitate online prescribing in an electronic medical record system. In this analysis, we studied the usage patterns of both favorites users and non-favorites users. Over a recent 3-month period, we found that 55 of 433 (12.7%) users had created and used a favorites list. We found that this feature is well used, but only by a subset of users. More opportunities exist to streamline online prescribing.
OpenAirInterface 5G NSA system with COTS phone (2020)

In this demo we show the current implementation status of the OpenAirInterface (OAI) 5G non-standalone (NSA) system operating with a common-of-the-shelf (COTS) phone in the sub-6 GHz band. The radio access network (RAN) comprises an OAI eNB and a gNB, both running on general purpose x86 servers and USRP N310 software defined radios. Further we use the OAI evolved packet core (EPC) comprising home subscriber server (HSS), mobility management entity (MME), serving and packet data network gateway (S-PGW), which are all deployed in Docker containers. In the demo we will show the initial connection and user registration on the 4G cell, the secondary cell addition, the initial connection on the 5G cell and some initial traffic on the 5G cell.
Gender Differences in Hostility Among Depressed and Medical Outpatients (1995)

We assessed possible gender differences in state and trait hostility in a large sample of depressed outpatients and in a group of medical outpatients. We administered the Cook and Medley Hostility Scale, measuring trait hostility and aggressiveness, and the Symptom Questionnaire, including a state measure of irritability and hostility, to 218 depressed outpatients and 51 medical outpatients. There was a statistically significant positive correlation between severity of depression and our state measure of hostility, and a weak, although statistically significant, relationship between severity of depression and total score of our trait measure of hostility. Among depressed outpatients, trait hostility was greater in men than in women, while no significant gender difference was observed in state hostility. Among medical outpatients, the state hostility scale scores were significantly higher in men than in women. These gender differences in both groups remained significant even after adjusting for severity of depression. Thus, it appears that men with depression tend to have higher scores than women on state and trait measures of hostility, suggesting that men may be at greater risk than women of developing patterns of pathologic aggression and hostile behavior.
Development of the Synchronously Pumped Optical Parametric Oscillator. (1990)

An investigation was made into the feasibility of using the synchronously pumped optical parametric oscillator (SPOPO) as a source of subnanosecond pulses tunable across the near- and mid-infrared. Two devices were developed, based on relatively new nonlinear crystals that had not previously been used as gain media in SPOPOs. Optical parametric oscillation, synchronously pumped by the amplified and then frequency doubled output from an actively mode locked and Q-switched Nd:YAG laser, was first achieved in beta-barium borate (BBO) and then in potassium titanyl phosphate (KTP). The BBO oscillator produced broadly tunable pulses covering ~0.68 to 2.4 µm, but its large double refraction walk-off angle, and critical phase matching, precluded tight pump beam focusing in the crystal, and this led to a high threshold peak pump intensity of ~2.2 GWcm&lt;sup&gt;-2&lt;/sup&gt; . The XTP crystal, used in the second SPOPO, allowed for non-critical phase matching, and had a higher nonlinear coefficient and smaller walk-off than BBO, and this gave a much lower threshold of ~650 MWcm&lt;sup&gt;-2 &lt;/sup&gt;(but limited tuning from ~1.04 to 1.09 µm). Both devices converted up to ~ 30% of the pump energy to generate ~ 75 ps parametric pulses.
Variable Projection Method and Levenberg-Marquardt Algorithm for Neural Network Training (2006)

An optimal solution for single hidden layered feedforward neural network (SLFN) is proposed. SLFN can be considered as separable nonlinear least squares problem and variable projection (VP) method gives the approximation of the Jacobian matrix of the problem. The Jacobian calculation of VP-SLFN is suggested with simplified form. Based on this simplification, Levenberg-Marquardt (LM) algorithm for VP-SLFN is suggested and has faster convergence rate than LM algorithm without VP. Two numerical examples show the superiority than extreme learning machine and LM without variable projection
A two‐dimensional liquid‐phase separation method coupled with mass spectrometry for proteomic studies of breast cancer and biomarker identification (2004)

A two-dimensional liquid-phase separation scheme coupled with mass spectrometry (MS) is presented for proteomic analysis of cell lysates from normal and malignant breast epithelial cell lines. Liquid-phase separations consist of isoelectric focusing as the first dimension and nonporous silica reverse-phase high-performance liquid chromatography (NPS-RP-HPLC) as the second dimension. Protein quantitation and mass measurement are performed using electrospray ionization-time of flight MS (ESI-TOF MS). Proteins are identified by peptide mass fingerprinting using matrix-assisted laser desorption ionization-time of flight MS (MALDI-TOF MS) and MALDI-quadrupole time of flight (QTOF)-tandem mass spectrometry (MS/MS). Two pH regions with 50-60 unique proteins in each pH range were chosen for analysis. Mass maps were created that allowed visualization of protein quantitation differences between normal and malignant breast epithelial cells. Of the approximately 110 unique proteins observed from mass mapping experiments over the limited pH range, 40 (36%) were positively identified by peptide mass fingerprinting and assigned to bands in the mass maps. Of these 40 proteins, 22 were more highly expressed in one or more of the malignant cell lines. These proteins represent potential breast cancer biomarkers that could aid in diagnosis, therapy, or drug development.
Abstract 12828: Association of Neighborhood Characteristics With Outcomes in Patients With Atrial Fibrillation in a Large Midwest Community (2022)

Background: The communities in which people live affect their health. We aimed to determine whether neighborhood characteristics are associated with outcomes in patients with atrial fibrillation (AF) in a Midwest community. Methods: Patients with incident AF from 2013-2017 from a 27-county region who survived &gt;90 days after their diagnosis were identified (N=14,725). Patient addresses were linked to publicly-available data on population density (rural-urban commuting area; RUCA) and neighborhood socioeconomic status (area deprivation index; ADI). Patients were followed for ischemic stroke or transient ischemic attack (TIA), heart failure (HF), dementia/delirium, and all-cause death through 2021. Cox regression determined risk of outcomes by RUCA category (urban, micropolitan, small rural, isolated) and ADI quartile after adjustment for age, sex, race/ethnicity, and CHA2DS2-VASc score. Results: After excluding persons missing race/ethnicity (n=46), RUCA (n=1,465), and ADI (n=1,640), 13,233 patients with AF (mean age 73.8 years, 57% men) remained. After a median follow-up of 4.7 years, 5,989 patients died; 582 experienced a stroke/TIA, 4,122 (of 9,156 patients at risk) developed HF, and 1,758 (of 12,154 patients at risk) developed dementia/delirium. Persons living in isolated areas (HR 1.14, 95% CI 1.05-1.24) and the highest ADI quartile (HR 1.59, 95% CI 1.37-1.85) experienced the greatest risk of death (Figure). A trend toward an increased risk of HF was observed for the 2 highest ADI quartiles (p-trend &lt;0.01), although the estimates did not reach statistical significance. The risk of other outcomes did not differ by RUCA or ADI category. Conclusion: Patients with AF residing in isolated areas and neighborhoods with greater area deprivation experience increased risks of death. Additional research is needed to better understand how neighborhood characteristics influence treatment, co-morbid conditions, and other outcomes in patients with AF.
ChemInform Abstract: Selective Endothelin A Receptor Antagonists. Part 2. Discovery and Structure‐Activity Relationships of 5‐Ketopentanoic Acid Derivatives. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.