gebhart/patrepeval huggingface dataset:
Physicochemical characterization of the androgen receptor from hyperplastic human prostate (1984)

Abstract In this manuscript we have characterized the androgen receptor from human benign prostatic hypertrophied (BPH) tissue. BPH tissue was obtained fresh from surgery, ground, and frozen in liquid nitrogen. Tissue was homogenized in 10 mM Tes buffer (pH 7.4 at 25°C) containing 0.25 M sucrose, 20 mM Na 2 MoO 4 , 12 mM monothioglycerol, and 1.5 mM EDTA. Cytosol was labeled with ( 3 H)‐R1881 (0.5–10 nM) ± a 100‐fold excess of R1881 and a 500‐fold excess of triamcinolone acetonide to identify specific androgen receptor sites. An exchange assay was developed, whereby maximum binding was achieved by raising the temperature to 30°C for 15 min. A high‐affinity binding protein was detected (Kd = 1.3 ± 0.8 nM) which had a binding capacity of 15 ± 7 fmol/mg protein. Binding was specific for androgens with the following Ki (nM) values: R1881 (0.09), dihydrotestosterone (6), testosterone (50), progesterone (92), estradiol (100), epitestosterone (860), and cortisol (&gt; 1,000). Under high ionic conditions the sedimentation coefficient of the receptor was 4.1 S. Higher S values were not observed in the presence of the following protein inhibitors: leupeptin (20 or 150 μM), iodoacetamide (10 mM), DFP (5 mM), PMSF (1 mM), bacitracin (0.1 mM), antipain (0.1 mM), aprotinin (1 TIU/ml). Gel filtration analysis revealed a Stokes radius of 6.5 nm. These data indicate a M r of 120,000 and a f/fo of 2.01. The receptor eluted from a chromatofocusing column at a pH of 6.8. The receptor bound to phosphocellulose and DNA cellulose after being heat‐treated for 15 min at 30°C. These results suggest that BPH tissue contains an androgen receptor which is similar to receptors in other androgen‐responsive tissues.
The Only Thing That Matters: Bringing the Power of the Customer into the Center of Your Business (1992)

The man who singlehandedly initiated the service management phenomenon in America poses the ultimate challenge for today's businesses--to rise above complacency. Based on Albrecht's years of practical application, the carefully crafted plan in this book shows how a company can reach the top and stay there.
Factors Associated with HIV Testing and HIV Treatment Adherence: A Systematic Review (2017)

The identification of persons who are less likely to test for HIV, and to adhere to HIV treatment, may serve as a guide for public health interventions, especially in resource-limited areas.
The randomized sample tree (2002)

We present a new data structure for rendering highly complex virtual environments of arbitrary topology. The special feature of our approach is that it allows an interactive navigation in very large scenes (30 GB/400 million polygons in our benchmark scenes) that cannot be stored in main memory, but only on a local or remote hard disk. Furthermore, it allows interactive rendering of substantially more complex scenes by instantiating objects.For the computation of an approximate image of the scene, a sampling technique is used. In the preprocessing, a so-called sample tree is built whose nodes contain randomly selected polygons from the scene. This tree only uses space that is linear in the number of polygons. In order to produce an image of the scene, the tree is traversed and polygons stored in the visited nodes are rendered. During the interactive walkthrough, parts of the sample tree are loaded from local or remote hard disk.We implemented our algorithm in a prototypical walkthrough system. Analysis and experiments show that the quality of our images is comparable to images computed by the conventional z-buffer algorithm regardless of the scene topology.
Effect of Temperature on Chemical Apple Thinning Results (1995)

An analysis of daytime high temperatures for the 10-year period from 1984 to 1993 indicated that, in the 21 days after full bloom (AFB) in 7 of 10 years, there were 3 days or more above 29.5C. In the 15- to 21-day period AFB, when fruit are considered at their optimum diameter (8 to 12 mm) for thinning, only 3 days above 29.5C were recorded. In the 15 to 21 days AFB, the high temperature was only 24C for 7 out of 10 years. Thus, growers would have to spray at temperatures 5.6C degrees lower if they were to choose to spray the warmest 3 days during the 15- to 21-day period when fruit are 8 to 12 mm in diameter. NAA caused thinning of `Golden Delicious' fruit at 8-mm fruit diameter. Tank mixing of one of several pesticides (regulaid or guthion, captan, carzol, imidan, polyram, lorsban, omite, or lannate) had no effect on NAA efficacy. Comparison of identical chemical thinning treatments (carbaryl + Accel + oil) applied to `York' and `Red Delicious' apple trees indicated that more thinning occurred with the PF treatments than at 8 mm. Average 2-day high temperatures at PF were 7.1C higher at PF for the `Red Delicious' experiment and 5.6C higher for the `York' experiment. The higher temperatures at PF could account for the differences in thinning response and not the spray timing. Pollination and fertilization inhibitors caused some fruit thinning at the highest rates and multiple applications. The MYX4801 caused more thinning and more injury to fruit than other materials. Endothall gave good thinning without fruit injury. Wilthin (GWN-6592) did cause some thinning, but fruit injury was a problem in one experiment.
Quiz Case 1 (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Otolaryngology–Head & Neck Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Otolaryngology–Head & Neck Surgery journal
Space-variant optical interconnection through the use of computer-generated holograms (1995)

A space-variant optical interconnection through the use of computer-generated holograms is proposed, and specific configurations to increase the number of parallel channels are analyzed. To this end, the well-known method based on a matrix composed of subholograms is applied. The field diffracted by each channel (assumed to be square apertures) is calculated through the angular-spectrum technique, and the resulting fields are suitably superimposed to obtain a hologram matrix with a reduced bandwidth. Results show that a compact transmissive planar configuration can be handled; in particular, the small interconnect distance between the array planes and the hologram yields a limited system volume.
On the Way to Optoionics (2020)

Abstract Based on the recent finding of significant ion conduction enhancement in iodide perovskites upon illumination, the potential of an emerging field ‘opto‐ionics’ – that we define in parallelism to ‘opto‐electronics’ – is explored. We emphasize that the major prerequisite is the identification of appropriate stable materials which can act as light‐tunable electrolytes, permeation membranes, or electrodes. In this way, classic, but light‐tunable electrochemical devices would be in reach. We also touch upon related issues such as sensing, switching, and catalysis, in which light effects on ionic charge carriers are also expected to be important.
Average consensus algorithms robust against channel noise (2008)

Average consensus algorithms have attracted popularity in the wireless sensor network scenario as a simple way to compute linear combinations of the observations gathered by the sensors, in a totally decentralized fashion, i.e., without a fusion center. However, average consensus techniques involve the iterated exchange of data among sensors. In a practical implementation, this interaction is affected by noise. The goal of this paper is to bring some common adaptive signal processing techniques into the sensor network context in order to robustify the iterative exchange of data against communication noise. In particular, we will compare the performance of two algorithms: (a) a method, reminiscent of stochastic approximation algorithms, using a decreasing step size, with proper decaying law, and (b) a leakage method imposing that the consensus cannot be too distant from the initial measurements. We provide a theoretical analysis, validated by simulation results, of both methods to show how to derive the best tradeoff between the system parameters in order to get the minimum estimation variance, taking into account both observation and interaction noise.
Differential Regulation of Two-Tiered Plant Immunity and Sexual Reproduction by ANXUR Receptor-Like Kinases (2017)

Plants have evolved two tiers of immune receptors to detect infections: cell surface-resident pattern recognition receptors (PRRs) that sense microbial signatures and intracellular nucleotide binding domain leucine-rich repeat (NLR) proteins that recognize pathogen effectors. How PRRs and NLRs interconnect and activate the specific and overlapping plant immune responses remains elusive. A genetic screen for components controlling plant immunity identified ANXUR1 (ANX1), a malectin-like domain-containing receptor-like kinase, together with its homolog ANX2, as important negative regulators of both PRR- and NLR-mediated immunity in <i>Arabidopsis thaliana</i> ANX1 constitutively associates with the bacterial flagellin receptor FLAGELLIN-SENSING2 (FLS2) and its coreceptor BRI1-ASSOCIATED RECEPTOR KINASE1 (BAK1). Perception of flagellin by FLS2 promotes ANX1 association with BAK1, thereby interfering with FLS2-BAK1 complex formation to attenuate PRR signaling. In addition, ANX1 complexes with the NLR proteins RESISTANT TO PSEUDOMONAS SYRINGAE2 (RPS2) and RESISTANCE TO P. SYRINGAE PV MACULICOLA1. ANX1 promotes RPS2 degradation and attenuates RPS2-mediated cell death. Surprisingly, a mutation that affects ANX1 function in plant immunity does not disrupt its function in controlling pollen tube growth during fertilization. Our study thus reveals a molecular link between PRR and NLR protein complexes that both associate with cell surface-resident ANX1 and uncovers uncoupled functions of ANX1 and ANX2 during plant immunity and sexual reproduction.
Polarization-mode dispersion cancellation using periodic polarization modulation (2003)

In this paper we present a novel approach allowing cancellation of the polarization mode dispersion (PMD) using a technique involving periodic polarization modulation. A digital post processing following the optical polarization modulation allows significant attenuation of the PMD component in the bit stream.
Collaborative positioning using landmark maps (2012)

In this paper we deal with a strategy for a collaborative positioning of vehicles to improve their ego positioning capabilities. One way to achieve this is the sharing of the vehicle's own position and additional measurements to vehicles with known position in their surrounding area.
Parametric mapping of the hepatic perfusion index with gadolinium-enhanced volumetric MRI (2007)

The purpose of this study was to adapt the hepatic perfusion index (HPI) methodology previously developed for MRI to derive 3D parametric maps of HPI, and to investigate apparent differences in HPI maps between a group of colorectal cancer patients and controls. To achieve this, a new and simpler approach to HPI calculation which does not require measurements from the aorta or portal vein is introduced, and assessed with large liver regions of interest (ROIs) in patients and controls. Several example HPI maps showing localized variation are then presented. The subject group consisted of 12 patients with known colorectal metastases, and 13 control subjects referred for routine contrast-enhanced spine imaging with no history of neoplastic disease. HPI was evaluated from serial T1 volume acquisitions acquired over the course of a Gd-DTPA bolus injection. Regions of abnormal perfusion were visible on the HPI maps derived for the patient group, manifested as areas of locally increased HPI extending around the visible margins of known metastases evident on the conventional contrast-enhanced images. This method for MR voxel-based parametric mapping of HPI has the potential to demonstrate regional variations in perfusion at the segmental and subsegmental level.
Microbial Community Dynamics during Rearing of Black Soldier Fly Larvae (Hermetia illucens) and Impact on Exploitation Potential (2018)

The need to increase sustainability in agriculture, to ensure food security for the future generations, is leading to the emergence of industrial rearing facilities for insects. One promising species being industrially reared as an alternative protein source for animal feed and as a raw material for the chemical industry is the black soldier fly (<i>Hermetia illucens</i>). However, scientific knowledge toward the optimization of the productivity for this insect is scarce. One knowledge gap concerns the impact of the microbial community associated with <i>H. illucens</i> on the performance and health of this insect. In this review, the first steps in the characterization of the microbiota in <i>H. illucens</i> and the analysis of substrate-dependent dynamics in its composition are summarized and discussed. Furthermore, this review zooms in on the interactions between microorganisms and the insect during <i>H. illucens</i> development. Finally, attention is paid to how the microbiome research can lead to alternative valorization strategies for <i>H. illucens</i>, such as (i) the manipulation of the microbiota to optimize insect biomass production and (ii) the exploitation of the <i>H. illucens</i>-microbiota interplay for the discovery of new enzymes and novel antimicrobial strategies based on <i>H. illucens</i> immunity using either the whole organism or its molecules. The next decade promises to be extremely interesting for this research field and will see an emergence of the microbiological optimization of <i>H. illucens</i> as a sustainable insect for industrial rearing and the exploitation of its microbiome for novel biotechnological applications.
Epoxy flux technology - Tacky flux with value added benefits (2009)

Since their inception over 30 years ago, underfills have enabled numerous new packages and have provided the required support and reliability needed for highly miniaturized and lead-free devices. It is safe to say that without these essential materials, many of today's advances would not be possible. Continued developments in underfill technology such as enhancements in filler technology, better control of flow rates, new cure mechanisms, improved modulus properties and alternative application techniques have brought enhanced performance capabilities to the market. But, as the industry continues its march forward toward more efficient, flexible and miniaturized devices and component configurations, even more underfill system capabilities will be required. To date, the four most commonly used types of underfills are capillary flow materials, fluxing (often referred to as no-flow) underfills, cornerbond and edgebond systems. Each of these have relevance for certain applications but some of the newer devices - and even some older generation packages - may benefit from a breakthrough underfill material technology in the reflow cured encapsulant class. The new material system - called epoxy flux - is enabling many applications in both semiconductor packaging and printed circuit board (PCB) assembly, as well as some of the emerging device configurations such as package-on-package (PoP).
Pseudo-Biomineralization: Complex Mineral Structures Shaped by Microbes (2019)

Biomineralization is an active, biologically governed process of mineral formation, established early on in the history of life. The appearance of biomineralizing organisms heavily influenced the course of evolution, leading to the development of the large diversity of the extant taxa. Yet, we are still only beginning to grasp the intricate, genetically regulated mechanisms involved. Since prokaryotic organisms were the first to emerge from the primordial environments, we investigated bacteria-mineral interactions using titration and gas diffusion systems adapted to emulate conditions, which may have facilitated the development of biomineralization initially. By screening the minerals and bacteria from titration experiments with scanning electron microscopy, we discovered a broad spectrum of behavioral strategies employed by bacteria confronted with calcification, which fell into three main categories: (1) evasion of mineralization by the formation of the biofilm, (2) random embedding into the mineral, and (3) control over the mineral shape during its formation. The latter phenomenon we termed pseudo-biomineralization. Our experiments indicate that pseudo-biomineralization is an active process obligatorily reliant on the external calcifying conditions and allowing considerable degree of control over mineral shape, thus producing structures reminiscent of true biominerals. Here, we describe this notion for the first time, thus providing vital insight into the genesis of a transitional stage to calcium carbonate-based biomineralization systems.
The Influence of Antitumor Unsymmetrical Bisacridines on 3D Cancer Spheroids Growth and Viability (2021)

The culture of 3D spheroids is a promising tool in drug development and testing. Recently, we synthesized a new group of compounds, unsymmetrical bisacridines (UAs), which exhibit high cytotoxicity against various human cell lines and antitumor potency against several xenografts. Here, we describe the ability of four UAs-C-2028, C-2041, C-2045, and C-2053-to influence the growth of HCT116 and H460 spheres and the viability of HCT116 cells in 3D culture compared with that in 2D standard monolayer culture. Spheroids were generated using ultra-low-attachment plates. The morphology and diameters of the obtained spheroids and those treated with UAs were observed and measured under the microscope. The viability of cells exposed to UAs at different concentrations and for different incubation times in 2D and 3D cultures was assessed using 7-AAD staining. All UAs managed to significantly inhibit the growth of HCT116 and H460 spheroids. C-2045 and C-2053 caused the death of the largest population of HCT116 spheroid cells. Although C-2041 seemed to be the most effective in the 2D monolayer experiments, in 3D conditions, it turned out to be the weakest compound. The 3D spheroid culture seems to be a suitable method to examine the efficiency of new antitumor compounds, such as unsymmetrical bisacridines.
Noncovalent Encapsulation Stabilities in Supramolecular Nanoassemblies (2010)

Exchange dynamics of lipophilic guest molecules, encapsulated in supramolecular nanoassemblies in aqueous solutions, have implications in evaluating the stability of drug delivery vehicles. This is because exchange dynamics is related to the propensity of a nanocarrier to be leaky. We describe a fluorescence resonance energy transfer (FRET) based method to evaluate guest exchange dynamics in the aqueous phase. We have utilized this method to analyze the stability of encapsulation in polymeric nanogels and other related amphiphilic nanoassemblies.
The Effects of Demand-Forecast Fluctuations on Customer Service and Inventory Cost When Demand is Lumpy (1987)

This paper examines the interactions between the demand forecasting and reordering subsystems in inventory management. Simulation is used to study the average discrepancy between a desired customer service level and that actually achieved, and the increase in average annual inventory cost resulting from fluctuations in the forecast demand parameters of several lumpy demand patterns.
Signalling at vanilloid TRPV1 channels (2004)

In this issue of the European Journal of Biochemistry, a prominent member of the transient receptor potential family of membrane channels, the transient receptor potential vanilloid type 1 protein (TRPV1), is the subject of three minireviews. TRPV1 channels were originally cloned while searching for a molecular target for two plant toxins: the fatty acid amide capsaicin, the well known pungent principle of hot chilli peppers (Capsicum sp.), and the phorboid resiniferatoxin, a much more potent vanilloid from Euphorbia sp. (Fig. 1). Both compounds contain a 3-methoxy-4-hydroxy-benzylamine (or ‘vanillamine’) moiety, previously shown to be a key determinant to observe potent activity in typical assays of vanilloid receptors. In fact, even before the cloning of TRPV1, strong evidence had been gained for the existence, in unmyelinized sensory fibers of the C type, of specific binding sites for capsaicin and resiniferatoxin, and extensive structure–activity studies had been performed for the former compound. It is now well established that other plant natural products, not necessarily containing a vanillyl structure, also activate TRPV1 receptors, although not as potently as capsaicin and resiniferatoxin. One of the major functions of this polymodal six transmembrane domain channel is, however, to act as one of several molecular transducers of painful physico-chemical stimuli, such as high temperatures (> 43°C) and acidity (pH < 6.5), and to intervene in inflammatory and thermal pain. The complex molecular regulation of the activity of TRPV1 is certainly key to understanding its role, while its detection, first in central neurons and more recently in epithelial cells, keratinocytes and (possibly) endothelial and glial cells, is likely to expand its participation to important (physio)pathological functions other than nociception. This possibility was also suggested by the finding of endogenous ligands of TRPV1 receptors, named ‘endovanilloids’, and led, among other things, to the proposition that these proteins, like other members of the TRP family, behave as receptor-operated channels in a large variety of conditions. The three minireviews in this issue of the journal focus on the most important biochemical issues concerned with the regulation of TRPV1 activity under both physiological and pathological conditions. Cortright & Szallasi provide a general overview of TRPV1 distribution, pharmacology and regulation by extracellular and intracellular signalling pathways, whereas Ferrer-Montiel and coworkers deal with the molecular aspects of TRPV1 gating and/or allosteric regulation by ligands. Finally, the article by van der Stelt & Di Marzo is a review of the new topic of endovanilloids, their biosynthetic and metabolic pathways, and their pharmacological actions. The intention is to provide the reader with state-of-the-art knowledge of what is starting to be seen as more than a temporarily ‘hot’ issue.