gebhart/patrepeval huggingface dataset:
Surface Modification of Graphitized Carbonaceous Thin-Film Electrodes with Silver for Enhancement of Interfacial Lithium-Ion Transfer (2012)

Graphitized carbonaceous thin-film electrodes prepared by plasma-assisted chemical vapor deposition were surface-modified with Ag, and their electrochemical properties were investigated by cyclic voltammetry and ac impedance spectroscopy. Insertion and extraction reactions of lithium ion at the underlying carbonaceous thin-film electrode took place at 0–0.15 V, which was similar to those for an untreated carbonaceous thin-film electrode. In the Nyquist plots, two distinct semicircles were observed at potentials below 1.0 V, which should be assigned to resistances for surface film and interfacial charge-transfer. The resistance for interfacial charge-transfer was much larger than that for an untreated carbonaceous thin-film electrode. The temperature dependence of the charge-transfer resistance showed Arrhenius-type behavior, and the activation energy for interfacial charge-transfer was evaluated. As a result, the Ag-deposited carbonaceous thin-film electrode gave an activation barrier lower than highly oriented pyrolytic graphite. These results suggest that the surface modification with Ag should significantly affect charge-transfer kinetics at the carbonaceous thin-film electrode.
De novo prediction of the genomic components and capabilities for microbial plant biomass degradation from (meta-)genomes (2013)

Our results show the potential of the method for generating novel insights into microbial plant biomass degradation from (meta-)genome data, where there is an increasing production of genome assemblages for uncultured microbes.
Sewing Worlds Together With SEAMs: A Mechanism to Construct Complex Virtual Environments (1999)

This paper introduces the Spatially Extended Anchoring Mechanism (SEAM) as a 3-D user-interface metaphor to connect virtual worlds and manage scalability in distributed virtual environments. SEAMs provide a visual and navigable connection between worlds to manage both the complexity of rendering and network communication typically occurring in such environments. In the context of augmented reality, SEAMs can be applied as a 3-D window interface. A rendering algorithm is described which performs well on the graphics accelerators of standard personal computers.
Supplementary Table from CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies (2023)

Supplementary Table from CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies
What Makes a Speaker Recognizable in TV Broadcast? Going Beyond Speaker Identification Error Rate (2015)

International audience
Receptor-Interacting Protein 140 Differentially Regulates Estrogen Receptor-Related Receptor Transactivation Depending on Target Genes (2006)

We have investigated the effects of receptor-interacting protein 140 (RIP140) on transcriptional regulation by estrogen receptor-related receptors (ERRs). We first show that RIP140 inhibits transactivation by ERRalpha, beta, and gamma on natural or artificial reporter genes containing different types of response elements. This repression correlates with a strong in vitro binding between several regions of RIP140 and the three ERR isoforms. Surprisingly, although RIP140 inhibits transactivation of the thyroid hormone receptor-alpha gene by ERRbeta, it significantly increases its regulation by ERRalpha and ERRgamma. Mutagenesis and transient transfections in SL2 cells indicate that thyroid hormone receptor-alpha promoter expression involved Sp1 sites. In support of this observation, we demonstrate that RIP140 also positively regulates ERRs transactivation of other known Sp1 targets such as the p21 gene. This effect requires the two proximal Sp1 binding sites of the promoter and is partially dependent on the activation function 2 domain of ERRs. Finally, we provide evidences for a role of histone deacetylases in the regulation of p21 promoter by RIP140. Altogether, these data indicate that RIP140 differentially regulates ERR activity depending on the target sequence on the promoters.
O3‐04‐03: Disrupted adult neurogenesis in a novel rat model of Alzheimer's disease (2011)

Alzheimer's disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and widespread cortical neuronal loss. The ‘amyloid cascade hypothesis’ posits that cerebral amyloid sets neurotoxic events into motion that precipitate Alzheimer dementia. While AD has been widely modeled in Abeta-overproducing transgenic mice, reproduction of all disease features in such models has remained elusive. We have developed a transgenic rat model on a Fischer 344 background (line TgF344-AD) based on over-expression of mutant human amyloid precursor protein and mutant human presenilin-1, each independent and dominant causes of familial early-onset AD. We applied histopathological, ultrastructural, and biochemical techniques to characterize this Tg rat model. Further, we determined expression of immature neuron markers in the ventricular zone, hippocampal dentate gyrus, and rostral migratory stream in Tg vs. wild-type rats. Tg rats faithfully recapitulate the hallmarks of AD age-dependent cerebral amyloidosis, tauopathy, gliosis, and most notably widespread apoptotic loss of neurons in the cerebral cortex and hippocampus leading to cognitive deficits. Results show age-dependent dysfunction within the neurogenic niche of this novel transgenic AD rat model, beginning prior to the appearance of frank AD-like pathology. Specifically, doublecortin and Tuj1 double-positive neural progenitors are depleted in Tg rats. Given the inverse relationship between adult neurogenesis and AD-like pathology in mouse models, these results add to a growing body of data pointing to aberrant adult neurogenesis in the context of AD.
Simple and Efficient Recyclable Catalytic System for Performing Copper‐Catalysed S‐Arylation Reactions in the Presence of Water (2007)

A novel protocol for the copper-catalysed S-arylation of thiophenol derivatives with aryl halides leading to diaryl sulfides is reported. The reactions were catalysed by a combination of a copper salt and a 1,2-diamine derivative (acting both as the ligand and as the base) using exclusively water as the solvent. The recovery and successful reutilisation of the aqueous medium containing the active catalyst is described. Furthermore, one example of a "one-pot" process involving Br/I exchange of an aryl bromide and further S-arylation is presented.
18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures. (2011)

18β-glycyrrhetinic acid and glabridin are potent antioxidants that prevent oxidative DNA fragmentation and the activation of apoptosis-associated proteins in human keratinocytes.
Citrate and action of vitamin D on calcium and phosphorus metabolism (1963)

Pantothenic acid and pyridoxine deficiencies in rats greatly minimized the rise in serum citrate following vitamin D administration without affecting the rise in serum calcium, serum phosphorus, and femur ash. In addition, pyridoxine deficiency reduced the response of bone citrate to the administration of vitamin D. The administration of cortisone acetate to rats on a low-calcium diet completely prevented the response of serum and bone citrate to vitamin D administration while having no effect on the response of serum calcium to vitamin D. These findings make it unlikely that an elevated citrate content of extracellular fluid and bone mediates the basic effects of vitamin D on mineral metabolism.
THE TEMPERATURE DEPENDENCE OF THE HYDROLYSIS OF METHYL ESTERS OF CERTAIN ALKYL-SUBSTITUTED BENZENESULPHONATES IN WATER (1959)

Rate data for the hydrolysis of a series of alkyl-substituted methyl benzenesulphonates are presented and the resulting differences in derived parameters are compared and discussed in an analysis of substituent effects.
Quantum Modeling of Ferric Iron (Fe3+)-Condensed Tannins Complexes (2019)

The condensed tannin-iron complex formation is one of the major causes of iron deficiency anaemia. Although, condensed tannins have beneficial virtues for the body and, as for iron, it participates in vital function such as breathing. In order to prevent this complex formation, we have undertaken to understand the complexing mechanism. We use quantum molecular modelling using quantum descriptors (energy gap, ionization energy, hardness, electrophilic index and softness) between ferric iron (Fe3+), major form of iron in the diet and catechin, epicatechin (major form of condensed tannins in diet). Calculations were made in gas phase using density functional theory (DFT) B3LYP/6-311+G (d,p). The results obtained show that we could have as complexes formed at the level of the organism catechin 4_BS, Epicatechin 2_BS that in strong magnetic field; Catechin 5_HS and Epicatechin 5_HS in weak field. We also notice that catechin and epicatechin have a low probability of complexing with ferric iron (Fe3+) with the hydroxyl group at position 3 whether in a strong field or a weak field. In further studies, more in-depth simulations coupled with experimentation, more understanding of these mechanisms will be given hoping to find solutions that would prevent the formation of condensed tannin-iron complexes.
Bilateral cochlear implants controlled by a single speech processor. (1998)

The ability of this subject to lateralize sounds on the basis of interaural delay or loudness difference, combined with the consonant identification results, supports further use of coordinated binaural stimulation to improve cochlear implant users' ability to understand speech, especially in the presence of competing speech noise.
Technetium-labeling of monoclonal antibodies with functionalized BATOs: 2. TcCl(DMG)3CPITC (CPITC=carboxyphenylisothiocyanate) labeling of B72.3 and NP-4 whole antibodies and NP-4 F(ab')2 (1991)

BATO (boronic acid adduct of technetium dioximes) complexes, TcCl(dioxime)3BR, were prepared in which the boron substituent (R) was the protein-reactive 2-carboxy-4-phenyl isothiocyanate (CPITC). The 99Tc complexes, where the dioxime was either dimethylglyoxime (DMG) or cyclohexanedione dioxime (CDO), were prepared and characterized. The 99mTc complex TcCl(DMG)3CPITC was prepared from a freeze-dried kit and used to label B72.3 (anti-TAG.72) and NP-4 (anti-CEA) whole antibodies, and the NP-4 F(ab')2 fragment. SDS-PAGE electrophoresis indicated that the labeling reagent was strongly bound to antibody. The labeled antibodies displayed high binding to affinity columns and good tumor uptake in GW39 tumor-bearing mice.
ChemInform Abstract: Synthesis of 1,3‐Diol Synthons from Epoxy Aromatic Precursors: An Approach to the Construction of Polyacetate‐Derived Natural Products. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High Response Valve for Active Combustion Control (2001)

This paper describes the development of a prototype high response fuel valve using piezoelectric actuator for fuel modulation control in gas turbine engines. In flow bench test, this prototype valve demonstrated 5∼11% peak-to-peak modulation strength at flow rates up to approximately 1500 pph and frequencies up to 500 Hz.
<title>Computer sumulations of the nonlinear joint transform correlator performance for disjoint signal and scene noise</title> (1993)

The correlation performance of nonlinear joint transform correlator for input signals containing a target in the presence of the input scene noise that is disjoint with the signal is investigated. It is shown that the binary joint transform correlator outperforms other types of nonlinear joint transform correlator for lowpass scene noise. Correlation tests using computer simulations are presented. The nonlinear joint transform correlator performance is determined for various degrees of nonlinear transformations and different input scene noise parameters. The investigations indicate that the correlation performance is sensitive to the bandwidth variation of the small bandwidth noise and is less sensitive to that of the wide band noise.
Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetase (2010)

Although Escherichia coli alanyl-tRNA synthetase was among the first tRNA synthetases to be sequenced and extensively studied by functional analysis, it has proved to be recalcitrant to crystallization. This challenge remained even for crystallization of the catalytic fragment. By mutationally introducing three stacked leucines onto the solvent-exposed side of an alpha-helix, an engineered catalytic fragment of the synthetase was obtained that yielded multiple high-quality crystals and cocrystals with different ligands. The engineered alpha-helix did not form a leucine zipper that interlocked with the same alpha-helix from another molecule. Instead, using the created hydrophobic spine, it interacted with other surfaces of the protein as a leucine half-zipper (LHZ) to enhance the crystal lattice interactions. The LHZ made crystal lattice contacts in all crystals of different space groups. These results illustrate the power of introducing an LHZ into helices to facilitate crystallization. The authors propose that the method can be unified with surface-entropy reduction and can be broadly used for protein-surface optimization in crystallization.
316 - Lewy Body Study: An Australian longitudinal biomarker study of dementia with Lewy bodies (2020)

Background: Cerebral multi-morbidity is common in older people with dementia, including people with dementia with Lewy bodies (DLB). We describe the first Australian-based, longitudinal observational biomarker study of DLB. Aims: To investigate the frequency and influence of Alzheimer’s disease (AD) pathology (amyloid-β and tau) and cerebrovascular disease on clinical symptoms and disease outcome in DLB. Methods: The study will recruit 100 people with mild to moderate probable DLB, who will undergo comprehensive clinical and cognitive assessments. Scales targeting DLB-specific clinical features (such as cognitive fluctuations and rapid eye movement sleep behaviour disorder) are administered. Biomarker protocols incorporate blood sampling (including ApoE genotyping and systemic inflammatory markers), molecular imaging (amyloid-β [18F-NAV 4694], tau [18F-MK6240], VMAT2 [18F-AV133] PET scans), 3-tesla magnetic resonance imaging and optional lumbar puncture. Clinical assessments are completed 6 - monthly and imaging 18-monthly. Participants are also invited to register for post-mortem brain tissue donation. Results: Thirty participants with probable DLB have been enrolled to date (mean age 75.4 years, range 64-82; 87% male). All participants have mild to moderate cognitive impairment (mean MMSE 25, range 17-30). Approximately 64% of the participants were amyloid-β positive. Study procedure tolerability has been excellent with no adverse events reported. Conclusions: There is significant overlap of AD-related proteinopathies in people with DLB. Understanding the impact of multi-morbidity is essential in the development of effective treatment strategies. This study supports the feasibility of intensive, longitudinal biomarker studies in DLB in the Australian setting.
Lattice-Reduction Aided Linear Equalizer Design for Linear Complex-Field Coded OFDM Systems (2006)

Orthogonal frequency division multiplexing (OFDM) is an effective method to deal with frequency-selective channels since it has low complexity equalization and decoding. To eliminate the effects of the channel nulls and enable multipath diversity, linear complex-field coded (LCFC-) OFDM is introduced and the maximum likelihood decoder is used to collect the diversity. But, the low complexity provided by OFDM is sacrificed. Recently it has been discovered that the performance of linear equalizers may be improved by using lattice-reduction (LR) techniques, in this paper, we analyze the performance of conventional linear equalizers for LCFC-OFDM systems. Then we develop LR aided linear equalizers for LCFC-OFDM systems and prove that complex LR aided linear equalizers collect the same diversity order as that offered by maximum likelihood detectors, but with much lower complexity. Simulation results corroborate the theoretical findings.
Highly Sensitive Tactile Shear Sensor Using Spatially Digitized Contact Electrodes (2019)

In this article, we report on a highly sensitive tactile shear sensor that was able to detect minute levels of shear and surface slip. The sensor consists of a suspended elastomer diaphragm with a top ridge structure, a graphene layer underneath, and a bottom substrate with multiple spatially digitized contact electrodes. When shear is applied to the top ridge structure, it creates torque and deflects the elastomer downwards. Then, the graphene electrode makes contact with the bottom spatially digitized electrodes completing a circuit producing output currents depending on the number of electrodes making contact. The tactile shear sensor was able to detect shear forces as small as 6 μN, detect shear direction, and also distinguish surface friction and roughness differences of shearing objects. We also succeeded in detecting the contact slip motion of a single thread demonstrating possible applications in future robotic fingers and remote surgical tools.
New Strategies for Anterior Cruciate Ligament Partial Rupture Using Bone Marrow Transplantation in Rats (2010)

The purpose of this study was to compare anterior cruciate ligament (ACL) regeneration between animal groups subjected to intra-articular injection of fresh whole bone marrow cells (BMCs), cultured mesenchymal stem cells (MSCs), or saline. Partially transected ACLs in Fischer 344/Nslc rats were prepared, followed by injection of BMCs, MSCs, or saline into the articular cavity at 1 week after transection. Donor cells expressing green fluorescent protein were detected in the recipient's transected ACLs at 4 weeks in the BMC and MSC groups, and their ACLs appeared almost normal histologically. Further, there were significantly more mature spindle cells in the BMC group than in the saline group at 4 weeks. Biomechanically, the tensile strength in the BMC group reached near normal levels at 4 weeks after injection. The levels of transforming growth factor-β1 in the ACL tissue and knee joint fluid in the BMC group were increased significantly compared with that of the saline group at 4 weeks as detected by immunohistochemical analysis. In conclusion, intra-articular bone marrow transplantation using fresh whole BMCs is an effective treatment for ACL partial rupture. This therapy is easy to apply in a clinical setting because no culture system is required for collecting MSCs.
A stackelberg game for power control and channel allocation in cognitive radio networks (2007)

The ongoing growth in wireless communication continues to increase demand on the frequency spectrum. The current rigid frequency band allocation policy leads to a significant under-utilization of this scarce resource. However, recent policy changes by the Federal Communications Commission (FCC) and research directions suggested by the Defense Advanced Research Projects Agency (DARPA) have been focusing on wireless devices that can adaptively and intelligently adjust their transmission characteristics, which are known as cognitive radios. This paper suggests a game theoretical approach that allows master-slave cognitive radio pairs to update their transmission powers and frequencies simultaneously. This is shown to lead to an exact potential game, for which it is known that a particular update scheme converges to a Nash Equilibrium (NE). Next, a Stackelberg game model is presented for frequency bands where a licensed user has priority over opportunistic cognitive radios. We suggest a modification to the exact potential game discussed earlier that would allow a Stackelberg leader to charge a virtual price for communicating over a licensed channel. We investigate virtual price update algorithms for the leader and prove the convergence of a specific algorithm. Simulations performed in Matlab verify our convergence results and demonstrate the performance gains over alternative algorithms.
A sparse multidimensional FFT for real positive vectors (2016)

We present a sparse multidimensional FFT (sMFFT) randomized algorithm for real positive vectors. The algorithm works in any fixed dimension, requires (O(R log(R) log(N)) ) samples and runs in O( R log^2(R) log(N)) complexity (where N is the total size of the vector in d dimensions and R is the number of nonzeros). It is stable to low-level noise and exhibits an exponentially small probability of failure.
Anticompulsive-like effect of nitric oxide synthase inhibitors in marble-burying test (2020)

Nitric oxide synthase (NOS) inhibitors decrease marble burying behavior (MBB), and the effect of several compounds that also attenuate MBB (such as classical antidepressants) engages the nitrergic system. In the present study, we tested the effect of the NOS inhibitor aminoguanidine (AMG) in attenuating MBB. For comparative reasons, we also tested the effect of selective inhibitors of neuronal (NOS1) and inducible (NOS2) isoforms NPA and 1400W, respectively. Our results indicate that AMG and NPA, but not 1400W, reduced the number of buried marbles in the marble burying test (MBT), which is considered an anticompulsive-like effect. No effect of AMG in the anxiety- or locomotor-related parameters of the elevated plus maze was observed. Taken together, our data is consistent with the current literature that suggests that nitric oxide inhibitors, putatively acting through the neuronal isoform of the synthesis enzyme (NOS1), exhibit anticompulsive-like properties.
4507 Dynamic analysys of the characteristics of the water system adsorption heat pumps using the various adsortion materials (2006)

Adsorption heat pump system is considered to be one of the most leading technologies to utilize low temperature thermal energy, because it can generate cold heat energy around 283K for air conditioning without any mechanical power by utilizing the low temperature heat as regeneration heat source of an adsorbent. Aiming to enhancement of cold-heat output of adsorption heat pump system, many theoretical and experimental studies have been already conducted. However, adsorption heat pump system still has problems for practical use. Most serious one is that cold heat output per unit volume of adsorption heat pump is much smaller than that of an absorption heat pump ; e.g. the silica gel-water type adsorption heat pump needs more than 4 times as big apparatus volume as absorption heat pump. As one of the solution to this problem, we have develop the automatic adsorbent test equipment, and estimated the new materials of adsorbents for adsorption heat pump from the view of the rate of adsorption. The results were 4 times as fast as that of silica gel-water system adsorption heat pump at a maximum, which approached the available size in the market.