gebhart/patrepeval huggingface dataset:
Saturation Mutagenesis of the β Subunit of the Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor Shows Clustering of Constitutive Mutations, Activation of ERK MAP Kinase and STAT Pathways, and Differential β Subunit Tyrosine Phosphorylation (1998)

The high-affinity receptors for human granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 are heterodimeric complexes consisting of cytokine-specific alpha subunits and a common signal-transducing beta subunit (hbetac). We have previously demonstrated the oncogenic potential of this group of receptors by identifying constitutively activating point mutations in the extracellular and transmembrane domains of hbetac. We report here a comprehensive screen of the entire hbetac molecule that has led to the identification of additional constitutive point mutations by virtue of their ability to confer factor independence on murine FDC-P1 cells. These mutations were clustered exclusively in a central region of hbetac that encompasses the extracellular membrane-proximal domain, transmembrane domain, and membrane-proximal region of the cytoplasmic domain. Interestingly, most hbetac mutants exhibited cell type-specific constitutive activity, with only two transmembrane domain mutants able to confer factor independence on both murine FDC-P1 and BAF-B03 cells. Examination of the biochemical properties of these mutants in FDC-P1 cells indicated that MAP kinase (ERK1/2), STAT, and JAK2 signaling molecules were constitutively activated. In contrast, only some of the mutant beta subunits were constitutively tyrosine phosphorylated. Taken together, these results highlight key regions involved in hbetac activation, dissociate hbetac tyrosine phosphorylation from MAP kinase and STAT activation, and suggest the involvement of distinct mechanisms by which proliferative signals can be generated by hbetac.
Synthesis of triheptanoin and formulation as a solid diet for rodents (2012)

Abstract Triheptanoin‐enriched diets have been successfully used in the experimental treatment of various metabolic disorders. Maximal therapeutic effect is achieved in the context of a ketogenic diet where triheptanoin oil provides 30–40% of the daily caloric intake. However, pre‐clinical studies using triheptanoin‐rich diets are hindered by the difficulty of administering to laboratory animals as a solid foodstuff. In the present study, we successfully synthesized triheptanoin to the highest standards of purity from glycerol and heptanoic acid, using sulfonated charcoal as a catalyst. Triheptanoin oil was then formulated as a solid, stable and palatable preparation using a ketogenic base and a combination of four commercially available formulation agents: hydrophilic fumed silica, hydrophobic fumed silica, microcrystalline cellulose, and talc. Diet compliance and safety was tested on C57Bl/6 mice over a 15‐week period, comparing overall status and body weight change. Practical applications: This work provides a complete description of (i) an efficient and cost‐effective synthesis of triheptanoin and (ii) its formulation as a solid, stable, and palatable ketogenic diet (triheptanoin‐rich; 39% of the caloric intake) for rodents. Triheptanoin‐rich diets will be helpful on pre‐clinical experiments testing the therapeutic efficacy of triheptanoin in different rodent models of human diseases. In addition, using the same solidification procedure, other oils could be incorporated into rodent ketogenic diet to study their dosage and long‐term effects on mammal health and development. This approach could be extremely valuable as ketogenic diet is widely used clinically for epilepsy treatment.
Correction to Organocatalysis: A Paradigm Shift in the Synthesis of Aliphatic Polyesters and Polycarbonates (2020)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Organocatalysis: A Paradigm Shift in the Synthesis of Aliphatic Polyesters and PolycarbonatesKazuki FukushimaKazuki FukushimaMore by Kazuki Fukushima and Kyoko NozakiKyoko NozakiMore by Kyoko NozakiCite this: Macromolecules 2020, 53, 17, 7613Publication Date (Web):August 26, 2020Publication History Published online26 August 2020Published inissue 8 September 2020https://pubs.acs.org/doi/10.1021/acs.macromol.0c01901https://doi.org/10.1021/acs.macromol.0c01901correctionACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1145Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (441 KB) Get e-Alertsclose Get e-Alerts
A new class of markov processes for image encoding (1988)

A new class of iterated function systems is introduced, which allows for the computation of non-compactly supported invariant measures, which may represent, for example, greytone images of infinite extent. Conditions for the existence and attractiveness of invariant measures for this new class of randomly iterated maps, which are not necessarily contractions, in metric spaces such as , are established. Estimates for moments of these measures are obtained. Special conditions are given for existence of the invariant measure in the interesting case of affine maps on . For non-singular affine maps on , the support of the measure is shown to be an infinite interval, but Fourier transform analysis shows that the measure can be purely singular even though its distribution function is strictly increasing.
Collaborative argument across the visual‐verbal interface (1993)

The essay begins with an intellectual framework for describing a visual‐verbal interface. Applying the implications of the framework to collaborative work, the authors illustrate ways in which they used this framework to observe and teach collaborative teams of graphic designers.
Reactive arthritis induced by Strongyloides stercoralis. (1996)

Reactive arthritis induced by Strongyloides is exceedingly rare. A case in a 53-year-old man from the Guadeloupe (French Antilles) is reported. The outcome was rapidly favorable under thiabendazole therapy. The cycle of Strongyloides is reviewed, and the contribution of parasites to reactive arthritis in patients with genetic risk factors is discussed. Establishing the correct diagnosis is sometimes difficult but is essential in order to avoid inappropriate administration of corticosteroids that can lead to fatal, multivisceral dissemination of the parasite, particularly in patients with strongyloidiasis.
Effects of Modifying Thioflavin T at the N3-Position on Its G4 Binding and Fluorescence Emission (2020)

We previously synthesized thioflavin T (ThT) with a hydroxyethyl group introduced at the <i>N</i><sup>3</sup>-position (ThT-HE), which binds predominantly to the parallel G-quadruplex (G4) structure found in c-Myc and emits strong fluorescence. In this study, to investigate the effects of introduced substituents on G4 binding and fluorescence emission, a ThT derivative in which the hydroxyl group of ThT-HE was replaced with an amino group (ThT-AE) was synthesized for the first time. Furthermore, three other <i>N</i><sup>3</sup>-modified ThT derivatives (ThT-OE2, ThT-SP, and ThT-OE11) having different substituent structures were synthesized by the N-acylation of the terminal amino group of ThT-AE, and their G4-binding and emission properties were investigated. The results showed that, although ThT-AE shows binding selectivity depending on the type of G4, its emission intensity is significantly decreased as compared to that of ThT-HE. However, ThT-OE11, which features an 11-unit oxyethylene chain attached to the terminal amino group of ThT-AE, regained about one-half of the emission intensity of ThT-HE while retaining selectivity for G4s. Accordingly, ThT-OE11 may be used as a key intermediate for synthesizing the conjugates of G4 binders and probes.
Rate-Splitting Multiple Access: Finite Constellations, Receiver Design, and SIC-free Implementation (2023)

Rate-Splitting Multiple Access (RSMA) has emerged as a novel multiple access technique that enlarges the achievable rate region of Multiple-Input Multiple-Output (MIMO) broadcast channels with linear precoding. In this work, we jointly address three practical but fundamental questions: (1) How to exploit the benefit of RSMA under finite constellations? (2) What are the potential and promising ways to implement RSMA receivers? (3) Can RSMA still retain its superiority in the absence of successive interference cancellers (SIC)? To address these concerns, we first propose low-complexity precoder designs taking finite constellations into account and show that the potential of RSMA is better achieved with such designs than those assuming Gaussian signalling. We then consider some practical receiver designs that can be applied to RSMA. We notice that these receiver designs follow one of two principles: (1) SIC: cancelling upper layer signals before decoding the lower layer and (2) non-SIC: treating upper layer signals as noise when decoding the lower layer. In light of this, we propose to alter the precoder design according to the receiver category. Through link-level simulations, the effectiveness of the proposed precoder and receiver designs are verified. More importantly, we show that it is possible to preserve the superiority of RSMA over Spatial Domain Multiple Access (SDMA), including SDMA with advanced receivers, even without SIC at the receivers. Those results therefore open the door to competitive implementable RSMA strategies for 6G and beyond communications.
Collaborative processing of Least-Square Monte Carlo for American options (2014)

American options are popularly traded in the financial market, so pricing those options becomes crucial in practice. In reality, many popular pricing models do not have analytical solutions. Hence techniques such as Monte Carlo are often used in practice. This paper presents a CPU-FPGA collaborative accelerator using state-of-the-art Least-Square Monte Carlo method, for pricing American options. We provide a new sequence of generating the Monte Carlo paths, and a precalculation strategy for the regression process. Our design is customisable for different pricing models, discretisation schemes, and regression functions. The Heston model is used as a case study for evaluating our strategy. Experimental results show that an FPGA-based solution could provide 22 to 64.5 times faster than a single-core CPU implementation.
Selective Atomic Layer Deposition (SALD) of Titanium Dioxide on Silicon and Copper Patterned Substrates (2010)

Atomic Layer Deposition (ALD) of TiO2 has potential applications in the microelectronics industry for purposes such as formation of the copper barrier layer. In this paper, TiO2 deposition on silicon and copper substrates is studied, with a focus on the initial growth and nucleation period on different substrates. Silicon with native oxide about 1.5 nm-thick, silicon with reduced oxide &lt;1 nm-thick, and silicon/copper patterned substrates with native oxide are tested for TiO2 deposition. The temperature-independent window on silicon is studied, and findings are used encourage selective deposition on the silicon portions of a copper-patterned silicon substrate. Selective ALD is found to be possible on silicon portions by taking advantage of the 15-20 cycle TiO2 nucleation period on copper, allowing a film approximately 2.5 nm-thick to grow on silicon while less than two monolayers grow on copper. Findings can be used in future work to further promote selective deposition of TiO2.
Telomerase activity in bladder cancer, bladder washings and in urine (1996)

With only a few exceptions, the ribonucleoprotein telomerase has been found in malignant, but not in benign tissues. Telomerase is thus a potentially new diagnostic marker. Carcinoma of the urinary bladder is the most frequent malignant tumor of the urinary tract and, after prostatic carcinoma, the second most common malignancy of the genitourinary system. In order to evaluate the diagnostic capabilities of telomerase in bladder carcinomas, four cell lines derived from human urothelial carcinomas of the bladder, 75 tissue samples from bladder carcinomas, eight tissue samples of normal bladder urothelium, 40 bladder washings and 30 urine samples were examined for telomerase activity. The four cell lines derived from urothelial carcinoma of the bladder (F975, 582, SCaBER, UM-UC-3) all exhibited high telomerase activity and were thus used as positive controls. Telomerase activity was found in nearly all (96%) tissue samples obtained from histologically confirmed urothelial carcinoma of the bladder. None of the normal tissue samples examined showed telomerase activity. Telomerase activity was similarly found in 73% of bladder washings in patients with histologically confirmed bladder carcinoma. There were no false positive results. The determination of telomerase activity in bladder washing samples thus represents a new diagnostic method for detection of tumor cells in rinsing media. Because of the early inactivation or degradation of telomerase there was no detection of the enzyme in native urine in the present study.
In situ growth of TiO2 nanocrystals on g-C3N4 for enhanced photocatalytic performance (2015)

Well dispersed TiO2 nanocrystals with (001) facets were successfully grown in situ on g-C3N4 through a facial solvothermal method. The resultant TiO2/g-C3N4 composites exhibit remarkably higher efficiency for photocatalytic degradation of phenol as compared to pure catalysts (g-C3N4 or TiO2) or mechanically mixed TiO2/g-C3N4. The optimal composite with 11.2 wt% TiO2 showed the highest degradation rate constant, which is 2.8 times that of pure g-C3N4, 2.2 times that of pure TiO2, and 1.4 times that of mechanically mixed TiO2/g-C3N4. The enhanced photocatalytic activity is mainly attributed to the effective charge separation derived from two aspects: (1) well matched energy levels between TiO2 and g-C3N4 and (2) a uniform and close contact between TiO2 and g-C3N4 that resulted from the in situ growth of highly dispersed TiO2 nanocrystals. The TiO2/g-C3N4 hybrid material prepared in this study is expected to provide a good foundation for the further design and synthesis of advanced TiO2/g-C3N4-based functional materials, and the in situ growth method developed is hopeful to provide a new strategy for the synthesis of other semiconductor-modified g-C3N4 materials.
Barrel Stave Osteotomy for Correction of Turribrachycephaly Craniosynostosis Deformity (1987)

The "barrel-stave" osteotomy procedure addresses the characteristic excessive height and reduced anteroposterior projection of the turribrachycephalic skull in one operative procedure. Four quadrant craniectomies are followed by barrel stave-like osteotomies in the parietooccipital region. The parietooccipital bone undergoing osteotomy is displaced posteriorly, thereby opening up the posterior fossa and effectively increasing the potential volume of the cranial vault. This increased capacity allows for notable reduction in skull height and reshaping of the skull along the anteroposterior axis.
Uplink Achievable Rate Maximization for Reconfigurable Intelligent Surface Aided Millimeter Wave Systems with Resolution-Adaptive ADCs (2020)

In this letter, we investigate the uplink of a reconfigurable intelligent surface (RIS)-aided millimeter-wave (mmWave) multi-user system. In the considered system, however, problems with hardware cost and power consumption arise when massive antenna arrays coupled with power-demanding analog-to-digital converters (ADCs) are employed. To account for practical hardware complexity, we consider that the access point (AP) is equipped with resolution-adaptive analog-to-digital converters (RADCs). We maximize the achievable rate under hardware constraints by jointly optimizing the ADC quantization bits, the RIS phase shifts, and the beam selection matrix. Due to the non-convexity of the feasible set and objective function, the formulated problem is non-convex and difficult to solve. To efficiently tackle this problem, a block coordinated descent (BCD)-based algorithm is proposed. Simulations demonstrate that an RIS can mitigate the hardware loss due to use of RADCs, and that the proposed BCD-based algorithm outperforms state-of-the-art algorithms.
Epilepsy patients treated with vigabatrin exhibit reduced ocular blood flow (2002)

A significant reduction in POBF and PA is apparent in epilepsy patients treated with AEDs when compared to normal subjects. A further reduction in POBF and PA is apparent between vigabatrin treated and conventionally treated patients. The reduction in ocular perfusion, which is more pronounced in patients previously treated with vigabatrin, may have implications in the impairment of visual function associated with the drug.
Berberine-Coated Biomimetic Composite Microspheres for Simultaneously Hemostatic and Antibacterial Performance (2021)

Biomimetic microspheres containing alginate/carboxymethylcellulose/gelatin and coated with 0%, 1%, 3%, and 6% berberine (BACG, BACG-1B, BACG-3B, BACG-6B) were prepared by the oil-in-water emulsion method combined with spray drying. Through a series of physicochemical parameters and determination of hemostatic properties in vitro and in vivo, the results indicated that BACG and BACG-Bs were effective in inducing platelet adhesion/aggregation and promoting the hemostatic potential due to their biomimetic structure and rough surface. In addition, BACG-6B with high berberine proportion presented better hemostatic performance compared with the commercial hemostatic agent compound microporous polysaccharide hemostatic powder (CMPHP). BACG-6B also showed strong antibacterial activity in the in vitro test. The hemolysis test and cytotoxicity evaluation further revealed that the novel composite biomaterials have good hemocompatibility and biocompatibility. Thus, BACG-6B provides a new strategy for developing a due-functional (hemostat/antibacterial) biomedical material, which may have broad and promising applications in the future.
Primary valve malfunction of the Krupin eye valve with disk. (1997)

Surgical revision in cases of primary valve malfunction of the Krupin eye valve with disk may be accomplished relatively safely with an acceptable level of postoperative complications. The etiology of primary valve malfunction may be related to the sterilization process and prolonged storage before implantation.
Diffusion in Partially Ion Exchanged Molecular Sieves (1974)

Results of a simple idealized numerical simulation are presented showing the variation of sorbate diffusivity with degree of ion exchange in a system such as the Na–Ca A zeolites. Theoretical curves showing the expected variation of diffusivity, diffusional activation energy, and pre-exponential factor are given. The pattern of behavior predicted depends on the ratio of the diffusivities for the extreme ionic forms. When this ratio is small there is a gradual variation in diffusivity, activation energy, and pre-exponential factor over the entire range of ionic compositions but for large ratios there is an abrupt change at a particular ionic composition. Limited experimental data for the diffusion of n-butane in partially Ca 2+ exchanged 4A sieve are presented and interpreted in terms of the theoretical model.
Technologies for Large-Scale Configuration Management (2002)

Structural-and-functional reorganization of the synovial membrane and articular cartilage in the knee joint was studied in rats with experimental chronic heart failure. Separation of fibers, decrease in the relative volume density of microcirculatory vessels, and increase in the expression of MMP-9 and caspase 3 were found in the synovial membrane. A decrease in the thickness of the surface layer (tendency to erosion), vacuolization and necrosis of chondrocytes, and increase in their readiness to programmed cell death were observed in the articular cartilage. Changes in the content of type II collagen and metachromasia were revealed in the cartilage matrix. These changes illustrate the development of degenerative arthropathy in cartilage components.
Kocuria kristinae: an emerging pathogen in medical practice (2019)

<b>Introduction.</b> <i>Kocuria kristinae</i> is becoming a growing public health challenge, especially for its ability to cause infections in immunocompromised patients. This bacterium is a Gram+coccus, catalase+, coagulase, and it is a common inhabitant of skin and oral mucosa.<b>Aim.</b> To investigate the spectrum of infections caused by <i>K.</i> <i>K</i> <i>ristinae</i>.<b>Methodology.</b> Between January-March 2018, we carried out a systematic search in PubMed utilizing the key search term '<i>Kocuria kristinae</i>'. The selection criteria for studies were studies reporting cases of human infections due to <i>K. kristinae</i>, case-control and cohort studies and studies published in English or Spanish.<b>Results.﻿</b> The literature search yielded 48 publications: after title, abstract and full-text analysis, 20 papers were consistent with the selection criteria. These studies were carried out in the period 2001-2017 in the USA, Japan, Taiwan, Hong Kong, Ukraine, Egypt, Bahrain, Serbia, India, Italy, Spain, Turkey and Mexico. <i>K. kristinae</i> was involved in 17 cases of central venous catheter-related bacteremia, four infective endocarditis, three acute peritonitis, one abdominal abscess, umbilical sepsis, acute cholecystitis and urinary tract infection. Additionally, <i>K. kristinae</i> was found in 40 % of carious cavities, although it is not clear whether they are directly involved in the development of caries. Antibiotic susceptibility testing has sometimes revealed multi-drug resistance.<b>Conclusions.</b> The clinical spectrum of <i>K. kristinae</i> infections has recently widened. The increasing spread of this underestimated bacterium and its resistance to antibiotics represent a new challenge for public health, which requires specific actions to limit it.
Object recognition using a tag (2002)

We propose a method for object recognition in an unconstrained condition. This includes wide range of illumination, unknown view points and complicated background. We simplified the general problem by placing special design patterns (Tsai's (1987) camera calibration chart) on the object that allows us to solve the pose determination problem easily. After establishing the methodological framework, we experiment with this technique on a wide range of real data to show the reliability of the approach. We argue that with this capability we should be able to (a) establish camera position with respect to a landmark, (b) recognise an object which is tagged with the calibration chart and (c) test any camera calibration and 3D pose estimation routines, thus facilitating future research and applications in mobile robots navigation, 3D reconstruction and stereo vision.