gebhart/patrepeval huggingface dataset:
<title>Effect of ultrasonic vibration on wedge indentation of a model elastoviscoplastic material</title> (2002)

A wedge indentation test has been carried out, in which an ultrasonic vibration was superimposed at a frequency of 20 kHz to investigate the effects of ultrasonic vibration on the indentation mechanics of Plasticine. A finite element simulation was employed as a basis for interpreting the experimental data. The model incorporated material and geometric non-linearity and the slide line method for modelling contact problems. &amp;lt;br /&amp;gt;The finite element results show that stress superposition only accounts for part of the load reduction measured under superimposed ultrasonic vibration, and that there are no temperature changes during the process. Consequently, the reduction in indentation load may be attributed to a combination of stress superposition and friction reduction.
Prevalence of contact dermatitis among dental personnel in a Swedish rural county. (2001)

The use of acrylate-based polymers in dental care in Sweden has increased dramatically in recent years. Acrylate monomers are sensitizers and can cause contact dermatitis. Allergy to latex, e.g. in rubber gloves, is also an increasing problem in health care and especially in dental care. The aim was to estimate the prevalences of work related allergies in dental personnel in a Swedish county with almost 700 dentists, dental nurses and dental hygienists. A questionnaire was distributed to all dental care units in the county and 98% of the population completed it. Specific allergy was verified with standard patch and prick testing. Work related allergy symptoms were reported by 189 subjects, 28%. The prevalences of acrylate eczema and latex allergy were 3,0% and 3,7% respectively. The prevalence of all work related skin allergy was estimated to 8%. The estimated prevalence of acrylate allergy was close to those of a few other published reports. However, the prevalence of hypersensitivity to latex rubber was lower than those reported from other studies. It is concluded that almost one dental care worker out of ten has a risk of contact dermatitis, unless measures to reduce hazardous exposure have been taken.
Transapical implantation of a self-expanding aortic valve bioprosthesis — animal feasibility study☆ (2009)

This study demonstrates the acute safety and feasibility of the CoreValve Tranzap delivery system for the transapical implantation of the CoreValve self-expanding aortic valve bioprosthesis in a porcine animal model.
Ion funnel ion trap and process (2023)

An ion funnel trap is described that includes a inlet portion, a trapping portion, and a outlet portion that couples, in normal operation, with an ion funnel. The ion trap operates efficiently at a pressure of .about.1 Torr and provides for: 1) removal of low mass-to-charge (m/z) ion species, 2) ion accumulation efficiency of up to 80%, 3) charge capacity of .about.10,000,000 elementary charges, 4) ion ejection time of 40 to 200 .mu.s, and 5) optimized variable ion accumulation times. Ion accumulation with low concentration peptide mixtures has shown an increase in analyte signal-to-noise ratios (SNR) of a factor of 30, and a greater than 10-fold improvement in SNR for multiply charged analytes.
Research on the Stress Measurement of Steel Plate Based on Inverse Magnetostrictive Effect (2014)

摘要： 改进传统四磁极传感器磁测方式，设计基于逆磁致伸缩效应用于钢板内应力在线检测的原理验证试验系统，研制在线动态检测的励磁模块和快速信号处理系统，在实验室完成验证和研究磁测钢板内应力的测试系统搭建。通过大量试验研究，获得磁通量与主应力之间基本稳定的定量关系及影响规律，验证两者之间的敏感相关关系，并详细讨论传感器参数对内应力测量结果的影响规律。试验研究证实针对带钢内应力进行在线磁测量方式检测的可行性，且该方法可能成为一种铁磁材料应力检测的新方法。
Functional expression of the human insulin gene in a human hepatoma cell line (HEP G2). (1995)

To develop a model somatic gene therapy system for diabetes, a human hepatoma cell line (HEP G2) was transfected with a mammalian expression vector carrying the full-length human insulin cDNA. More proinsulin than insulin was released daily by the stably transformed cell line (HEP G2ins). However, on acute stimulation with 5mM 8-Br-cAMP and 10mM theophylline the HEP G2ins cells released predominantly insulin into the medium. The cells did not secrete insulin in response to glucose. Examination of acid-ethanol extracts confirmed insulin was preferentially being stored. Immunohistochemical analysis of the cells also showed (pro)insulin was being stored. Electron microscopy revealed large membrane-bound vacuoles, containing electron-dense material, which were not seen in control cells. Glucokinase activity and albumin secretion of the transfectants were unaltered from the controls. Five-minute pulse-chase labelling of the HEP G2ins cells with 3H-leucine confirmed insulin synthesis in the presence of 20mM glucose and 5mM 8-Br-cAMP. A dose-response curve for insulin synthesis was also generated to increasing concentrations of glucose with a half Vmax of 4.9mM. Our results show that the introduction of insulin cDNA into a human hepatoma cell line results in synthesis, storage and acute regulated insulin release and lend credence to the possibility of engineering a liver cell to secrete insulin acutely in response to physiological stimuli.
ChemInform Abstract: Chemo‐Enzymatic Approach to the Synthesis of Each of the Four Isomers of α‐Alkyl‐β‐fluoroalkyl‐substituted β‐Amino Acids. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
International Perspectives on Quality Assessment of Deep Mixing (2004)

A wide range of in situ techniques has been developed in the last two decades in Europe and Asia to assess the quality of deep mixed soil columns. These methods use either conventional or specially designed tools to penetrate into the hard columns (such as pushing, pulling, rotary, driven, or displacement methods); or use geophysical concepts (such as seismic, resistivity, and echo-pulse methods). The main objective of this paper is to present the results of an international survey conducted for the quality assessment of deep mixed columns. The objectives were (a) to identify the most commonly accepted field methods of quality assessment practiced in different parts of the world, and (b) to understand the operational problems occurred when the method was applied for deep mixing projects. The respondents of the survey had diverse backgrounds, which included engineers, academicians, researchers, and contractors. The summary of the international survey provided valuable insights for the selection of in situ techniques for the quality assessment of deep mixing projects.
Amorphous Ti-Si alloy formed by interdiffusion of amorphous Si and crystalline Ti multilayers (1987)

Reactions upon rapid thermal annealing of sputtered Ti-Si multilayers have been studied by cross-section and through-foil transmission electron microscopy, glancing-angle Rutherford backscattering, and x-ray diffraction. The compositions of the samples are 40 at. % Ti, 60 at. % Si and 60 at. % Ti, 40 at. % Si, and the bilayer periodicity is about 10 nm. The silicon layers in the as-deposited films are amorphous; the titanium layers are polycrystalline hcp. After a 30-s anneal at 455 °C, significant interdiffusion occurs and we observed the formation of an amorphous Ti-Si alloy by interfacial reaction. The metastable disilicide, C49 TiSi2, nucleated along with a small amount of TiSi in the sample with higher silicon content (60%) upon annealing at 550 °C for 10 s, but the amorphous alloy remained as the only product of reaction in the 40-at. % Si sample.
Layered TiS2 Positive Electrode for Mg Batteries (2016)

Magnesium batteries are a good candidate for high energy storage systems, but the limited discovery of functional positive electrode materials beyond the seminal Chevrel phase (Mo6S8) has slowed their development. Herein, we report on layered TiS2 as a promising positive electrode intercalation material, providing 115 mAh g–1 stabilized capacity in a Mg full cell. Reversible Mg2+ intercalation into the structure is proven by elemental analysis combined with X-ray diffraction studies that elucidate the phase behavior upon cycling. The voltage profiles reveal distinct Mg2+ cation ordering, unlike the solid solution behavior exhibited by Li+. Our findings not only point to the important role of “soft” lattices to facilitate divalent solid-state cation mobility but also now provide an alternative sulfide to serve as a platform for the fundamental understanding of Mg2+ intercalation in lattices.
Increased Klk9 Urinary Excretion Is Associated to Hypertension-Induced Cardiovascular Damage and Renal Alterations (2015)

Early detection of hypertensive end-organ damage and secondary diseases are key determinants of cardiovascular prognosis in patients suffering from arterial hypertension. Presently, there are no biomarkers for the detection of hypertensive target organ damage, most outstandingly including blood vessels, the heart, and the kidneys.We aimed to validate the usefulness of the urinary excretion of the serine protease kallikrein-related peptidase 9 (KLK9) as a biomarker of hypertension-induced target organ damage.Urinary, plasma, and renal tissue levels of KLK9 were measured by the Western blot in different rat models of hypertension, including angiotensin-II infusion, DOCA-salt, L-NAME administration, and spontaneous hypertension. Urinary levels were associated to cardiovascular and renal injury, assessed by histopathology. The origin of urinary KLK9 was investigated through in situ renal perfusion experiments.The urinary excretion of KLK9 is increased in different experimental models of hypertension in rats. The ACE inhibitor trandolapril significantly reduced arterial pressure and the urinary level of KLK9. Hypertension did not increase kidney, heart, liver, lung, or plasma KLK9 levels. Hypertension-induced increased urinary excretion of KLK9 results from specific alterations in its tubular reabsorption, even in the absence of overt nephropathy. KLK9 urinary excretion strongly correlates with cardiac hypertrophy and aortic wall thickening.KLK9 appears in the urine in the presence of hypertension as a result of subtle renal handling alterations. Urinary KLK9 might be potentially used as an indicator of hypertensive cardiac and vascular damage.
Protein-Protein Interactions of the Primase Subunits p58 and p48 with Simian Virus 40 T Antigen Are Required for Efficient Primer Synthesis in a Cell-free System (2000)

DNA polymerase alpha-primase (pol-prim, consisting of p180-p68-p58-p48), and primase p58-p48 (prim(2)) synthesize short RNA primers on single-stranded DNA. In the SV40 DNA replication system, only pol-prim is able to start leading strand DNA replication that needs unwinding of double-stranded (ds) DNA prior to primer synthesis. At high concentrations, pol-prim and prim(2) indistinguishably reduce the unwinding of dsDNA by SV40 T antigen (Tag). RNA primer synthesis on ssDNA in the presence of replication protein A (RPA) and Tag has served as a model system to study the initiation of Okazaki fragments on the lagging strand in vitro. On ssDNA, Tag stimulates whereas RPA inhibits the initiation reaction of both enzymes. Tag reverses and even overcompensates the inhibition of primase by RPA. Physical binding of Tag to the primase subunits and RPA, respectively, is required for these activities. Each subunit of the primase complex, p58 and p48, performs physical contacts with Tag and RPA independently of p180 and p68. Using surface plasmon resonance, the dissociation constants of the Tag/pol-prim and Tag/primase interactions were 1.2 x 10(-8) m and 1.3 x 10(-8) m, respectively.
Statistical Relational Learning (2017)

Machine learning and database approaches to structured probabilistic models share many commonalities, yet exhibit certain important differences. Machine learning methods focus on learning probabilistic models from (certain) data and efficient learning and inference, whereas probabilistic database approaches focus on storing and efficiently querying uncertain data. Nonetheless, the structured probabilistic models that both use are often (almost) identical. In this tutorial, I will overview the field of statistical relational learning (SRL) [1] and survey common approaches. I'll make connections to work in probabilistic databases [2], and highlight commonalities and differences among them. I'll close by describing some of our recent work on probabilistic soft logic [3].
Convenient Procedures for the Laboratory Preparation of Borazine (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConvenient Procedures for the Laboratory Preparation of BorazineThomas Wideman and Larry G. SneddonCite this: Inorg. Chem. 1995, 34, 4, 1002–1003Publication Date (Print):February 1, 1995Publication History Published online1 May 2002Published inissue 1 February 1995https://pubs.acs.org/doi/10.1021/ic00108a039https://doi.org/10.1021/ic00108a039research-articleACS PublicationsRequest reuse permissionsArticle Views1968Altmetric-Citations103LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Improved Signal-to-noise Ratio in Glow Discharge Ion Trap Mass Spectrometryvia Pulsed Discharge Operation (1997)

An improvement in the S/N ratio is reported for the analysis of trace elements in brass by glow discharge ion trap mass spectrometry. This was achieved by synchronizing the pulsed discharge voltage with the ion injection and acquisition events; ‘on’ during ion injection and ‘off’ during data acquisition. Two modes of operation were evaluated: (1) a high duty cycle pulse, which allowed a continuous injection over the duration of the pulse; and (2) a low duty cycle pulse with multiple data gates, which allowed gated injections of ions at selected regions of the pulse profile. The latter afforded a means of selective ion injection since discharge and residual gas species are formed at different times in the pulse event than analyte ions. Improvements in S/N ratios greater than 40-fold were observed, primarily due to a reduction in background and background noise after the discharge was extinguished. Evidence is presented which suggests that electrons emanating from the ion source are the precursors of most of the noise. Detection limits for various elements were 0.2–0.5 ppm.
Exchange Bias in FePt–FePt3 Thin Films by Controlled Phase Transition of Blended Nanoparticle Building Blocks (2020)

Nanostructured composite thin films showing magnetic exchange coupling at the material interface have attracted great interest for the development of electronic components such as spin-valves. Besides the commonly performed fabrication of multilayer systems, the utilization of nanoparticle building blocks holds great potential for thin films with tailored magnetic properties and allows the facile but controlled combination of materials with complementary magnetic characteristics. In this work, we present the use of prefabricated highly crystalline iron platinum (fcc-FePt) and iron oxide (Fe<sub><i>x</i></sub>O<sub><i>y</i></sub>) nanoparticles for the preparation of nanocomposite thin films with varying compositions by wet processing from mixed dispersions. The resulting multiphase coatings showed high homogeneity, low surface roughness, and superparamagnetic behavior. By the variation of the amount of incorporated iron oxide, a precise adjustment of the magnetization at high field strength could be achieved. Furthermore, calcination under inert gas atmosphere resulted in a controlled phase transition of the magnetic phases and thus, in purely metallic coatings composed of ferromagnetic fct-FePt and antiferromagnetic fcc-FePt<sub>3</sub>, a decrease in surface roughness as well as high magnetic coercivity at room temperature. Field-cooling below the Néel temperature of fcc-FePt<sub>3</sub> led to an exchange bias effect with a strong increase in coercivity and the characteristic hysteresis shift. In comparison to the literature, our nanocomposite thin films showed fully ordered phases without the occurrence of phase impurities, a distinctly higher coercivity, and an exchange bias shift of 38.7 mT.
Hematological Disorders in Human Patients with Son Mutations (2019)

Precise regulation of transcription and RNA splicing is critical for controlling hematopoietic cell fate determination and lineage differentiation. Alteration of expression of lineage-specific transcription factors and several core spliceosome components in hematopoietic malignancies highlight the significance of abnormal transcription and RNA splicing as disease-causing factors. Our group previously demonstrated that SON, a large nuclear speckle protein possessing dual abilities to bind both DNA and RNA, functions as a splicing factor as well as a transcriptional repressor. We recently identified heterozygous loss-of-function mutations in the SON gene from children with intellectual disability and developmental delay often with a broad spectrum of other congenital anomalies. The disorder caused by SON haploinsufficiency has been designated as ZTTK syndrome (Zhu-Tokita-Takenouchi-Kim syndrome; OMIM #617140). The majority of the mutations found in these patients are frameshift or nonsense mutations which cause degradation of the mutation-bearing transcript. While the most prominent features of these patients are brain malformations and musculoskeletal abnormalities, we identified various hematological disorders from children with ZTTK syndrome. Notable symptoms include bone marrow failure, severe anemia, immunoglobulin deficiency, thalassemia, polycythemia, polycythemia vera, stroke due to blood clots, and leukocytopenia. Apart from the ZTTK syndrome, SON is known to be upregulated in acute myeloid leukemia (AML) patients and is correlated to altered hematopoietic differentiation. To investigate how altered SON expression affects hematopoiesis, we generated a mouse line with the Son gene deleted specifically in the hematopoietic lineage. Homozygous deletion of Son in hematopoietic lineage led to embryonic lethality, indicating that SON expression in blood cells is indispensable during development. Mice with heterozygous deletion of Son in the hematopoietic lineage were viable and born without notable defects or sign of diseases. However, there is a significant decrease in bone marrow cellularity in the mice with heterozygous deletion of Son. Furthermore, Son haploinsufficiency decreased the size of the lineage negative (Lin-) cell population and short-term hematopoietic stem cell (ST-HSC) population with a concurrent increase in megakaryocyte/erythrocyte lineage-biased multipotent progenitors (MPP2) within hematopoietic stem/progenitor cells. These findings suggest that the level of Son expression potentially affects stem cell maintenance and MPP lineage bias, and the distortion of the subpopulation balance within hematopoietic stem/progenitors is possibly linked to multiple hematological disorders. Our ongoing analyses of hematopoiesis and gene expression changes using this mouse model will expand our knowledge about the role of SON in several hematological disorders and benefit clinical practice for ZTTK syndrome patients. Disclosures No relevant conflicts of interest to declare.
Influence of oxygen on the formation mechanism of silver nanoparticles formed by laser exposure of glassy matrix (2015)

International audience
Cytotoxic Effects of Inhibitors of de Novo Pyrimidine Biosynthesis upon Plasmodium falciparum (1994)

The malarial parasite Plasmodium falciparum can only synthesize pyrimidine nucleotides via the de novo pathway which is therefore a suitable target for development of antimalarial drugs. New assay procedures have been developed using high-pressure liquid chromatography (HPLC) which enable concurrent measurement of pyrimidine intermediates in malaria. Synchronized parasites growing in erythrocytes were pulse-labeled with [14C]bicarbonate at 6-h intervals around the 48-h asexual life cycle. Analysis of malarial extracts by HPLC showed tht incorporation of [14C]bicarbonate into pyrimidine nucleotides was maximal during the transition from trophozoites to schizonts. The reaction, N-carbamyl-L-aspartate-->L-dihydroorotate (CA-asp-->DHO) catalyzed by malarial dihydroorotase is inhibited by L-6-thiodihydroorotate (TDHO) in vitro (Ki = 6.5 microM), and TDHO, as the free acid or methyl ester, induces a major accumulation of CA-asp in malaria. Atovaquone, a naphthoquinone, is a moderate inhibitor of dihydroorotate dehydrogenase in vitro (Ki = 27 microM) but induces major accumulations of CA-asp and DHO. Pyrazofurin induces accumulation of orotate and orotidine in malaria, consistent with inhibition of orotidine 5'-monophosphate (OMP) decarboxylase with subsequent dephosphorylation of the OMP accumulated. Although TDHO, atovaquone, and pyrazofurin arrest the growth of P. falciparum, only moderate decreases in UTP, CTP, and dTTP were observed. 5-Fluoroorotate also arrests the growth of P. falciparum with major accumulations of 5-fluorouridine mono-, di-, and triphosphates and the most significant inhibition of de novo biosynthesis of pyrimidine nucleotides.
Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes (2021)

In the male germ cells of placental mammals, 26-30-nt-long PIWI-interacting RNAs (piRNAs) emerge when spermatocytes enter the pachytene phase of meiosis. In mice, pachytene piRNAs derive from ~100 discrete autosomal loci that produce canonical RNA polymerase II transcripts. These piRNA clusters bear 5' caps and 3' poly(A) tails, and often contain introns that are removed before nuclear export and processing into piRNAs. What marks pachytene piRNA clusters to produce piRNAs, and what confines their expression to the germline? We report that an unusually long first exon (≥ 10 kb) or a long, unspliced transcript correlates with germline-specific transcription and piRNA production. Our integrative analysis of transcriptome, piRNA, and epigenome datasets across multiple species reveals that a long first exon is an evolutionarily conserved feature of pachytene piRNA clusters. Furthermore, a highly methylated promoter, often containing a low or intermediate level of CG dinucleotides, correlates with germline expression and somatic silencing of pachytene piRNA clusters. Pachytene piRNA precursor transcripts bind THOC1 and THOC2, THO complex subunits known to promote transcriptional elongation and mRNA nuclear export. Together, these features may explain why the major sources of pachytene piRNA clusters specifically generate these unique small RNAs in the male germline of placental mammals.