gebhart/patrepeval huggingface dataset:
Structural effects on the luminescence properties of CsPbI3 nanocrystals (2023)

Metal halide perovskite nanocrystals (NCs) are promising for photovoltaic and light-emitting applications. Due to the softness of their crystal lattice, structural modifications have a critical impact on their optoelectronic properties. Here we investigate the size-dependent optoelectronic properties of CsPbI<sub>3</sub> NCs ranging from 7 to 17 nm, employing temperature and pressure as thermodynamic variables to modulate the energetics of the system and selectively tune the interatomic distances. By temperature-dependent photoluminescence spectroscopy, we have found that luminescence quenching channels exhibit increased non-radiative losses and weaker exciton-phonon coupling in bigger particles, in turn affecting the luminescence efficiency. Through pressure-dependent measurements up to 2.5 GPa, supported by XRD characterization, we revealed a NC-size dependent solid-solid phase transition from the γ-phase to the δ-phase. Importantly, the optical response to these structural changes strongly depends on the size of the NC. Our findings provide an interesting guideline to correlate the size and structural and optoelectronic properties of CsPbI<sub>3</sub> NCs, important for engineering the functionalities of this class of soft semiconductors.
Depletion of eosinophil infiltration by anti-IL-5 monoclonal antibody (TRFK-5) accelerates open skin wound epithelial closure. (1997)

Wound healing is critical to the survival of the species after injury. Using hamsters as an experimental model, we have shown that eosinophils infiltrate prominently into skin wounds and that they express transforming growth factor-alpha and -beta 1 mRNAs and proteins. We hypothesized that eosinophils are important in wound healing. As no animal model is genetically deficient in eosinophils, a suitable way to test the hypothesis is to selectively reduce and/or deplete the influx of eosinophils into the wound sites. In this study, we report that anti-interleukin-5 monoclonal antibody (TRFK-5) treatment can deplete eosinophils in cutaneous healing wounds. We found that wound closure by re-epithelialization in the experimental group was 4 days faster than in the control group (P < 0.01). The density of eosinophils in day-9 wounds was significantly lower in the experimental group (P < 0.01). Wound-associated eosinophils in each of the TRFK-5-treated hamsters were depleted to the level comparable to unwounded hamster skin. These results demonstrate that anti-interleukin-5 monoclonal antibody treatment can effectively decrease eosinophil infiltration into hamster cutaneous healing wounds and indicate a role for eosinophils in negatively affecting wound re-epithelialization.
Ultra wide field angiography documented peripheral retinal eovascularization as cause of vitreous hemorrhage after scleral buckle surgery# (2020)

We describe an unusual case of ultra wide fluorescein angiography (UWFA) documented peripheral retinal neovascularization (NVE) with delayed vitreous hemorrhage after placement of an encircling scleral buckle (a common procedure for repair of retinal detachment). Anterior segment ischemia is a rare complication after scleral buckle surgery for the treatment of retinal detachment and results from altered choroidal flow through the impingement of the anterior and long posterior ciliary arteries. UWFA performed for the evaluation of vitreous hemorrhage confirmed ischemia anterior to the scleral buckle and consequential NVE. This case represents the utility of UWFA in evaluating and managing this exceptionally rare complication associated with a common procedure in the field of vitreoretinal surgery.
Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals (2016)

Although Neandertal sequences that persist in the genomes of modern humans have been identified in Eurasians, comparable studies in people whose ancestors hybridized with both Neandertals and Denisovans are lacking. We developed an approach to identify DNA inherited from multiple archaic hominin ancestors and applied it to whole-genome sequences from 1523 geographically diverse individuals, including 35 previously unknown Island Melanesian genomes. In aggregate, we recovered 1.34 gigabases and 303 megabases of the Neandertal and Denisovan genome, respectively. We use these maps of archaic sequences to show that Neandertal admixture occurred multiple times in different non-African populations, characterize genomic regions that are significantly depleted of archaic sequences, and identify signatures of adaptive introgression.
Naturally Activated Vγ4 γδ T Cells Play a Protective Role in Tumor Immunity through Expression of Eomesodermin (2010)

We previously demonstrated that gammadelta T cells played an important role in tumor immune surveillance by providing an early source of IFN-gamma. The precise role of different subsets of gammadelta T cells in the antitumor immune response, however, is unknown. Vgamma1 and Vgamma4 gammadelta T cells are the principal subsets of peripheral lymphoid gammadelta T cells and they might play distinct roles in tumor immunity. In support of this, we observed that reconstitution of TCRdelta(-/-) mice with Vgamma4, but not Vgamma1, gammadelta T cells restored the antitumor response. We also found that these effects were exerted by the activated (CD44(high)) portion of Vgamma4 gammadelta T cells. We further determined that IFN-gamma and perforin are critical elements in the Vgamma4-mediated antitumor immune response. Indeed, CD44(high) Vgamma4 gammadelta T cells produced significantly more IFN-gamma and perforin on activation, and showed greater cytolytic activity than did CD44(high) Vgamma1 gammadelta T cells, apparently due to the high level of eomesodermin (Eomes) in these activated Vgamma4 gammadelta T cells. Consistently, transfection of dominant-negative Eomes in Vgamma4 gammadelta T cells diminished the level of IFN-gamma secretion, indicating a critical role of Eomes in the effector function of these gammadelta T cells. Our results thus reveal distinct functions of Vgamma4 and Vgamma1 gammadelta T cells in antitumor immune response, and identify a protective role of activated Vgamma4 gammadelta T cells, with possible implications for tumor immune therapy.
Prediction of Low-Energy Collision-Induced Dissociation Spectra of Peptides with Three or More Charges (2005)

A kinetic model, based on the "mobile proton" model of peptide fragmentation, has been reported previously for quantitative prediction of low-energy collision-induced dissociation (CID) spectra of singly or doubly charged peptides. For peptides with three or more charges, however, the simulation process is complex and time-consuming. This paper describes a simplified model for quantitative prediction of CID spectra of peptide ions with three or more charges. Improvements on other aspects of the model were also made to accommodate large peptides. The performance of the simplified model was evaluated by generating predictions for many known highly charged peptides that were not included in the training data set. It was shown that the model is able to predict peptide CID spectra with reasonable accuracy in fragment ion intensities for highly charged peptide ions up to 5000 u in mass.
A Phased Approach to Increase Airport Capacity through Safe Reduction of Existing Wake Turbulence Constraints (2003)

Previous wake turbulence research has suggested that using knowledge of wake turbulence behavior to develop candidate arrival and departure procedures would increase capacity at a variety of United States airports. This paper outlines the operational issues involved as well as the process through which the Federal Aviation Administration (FAA) and The MITRE Corporation’s Center for Advanced Aviation System Development (MITRE/CAASD) analyzed an evolving set of candidate procedures. This work is part of the broader effort to implement an FAA/National Aeronautics and Space Administration (NASA) Wake Turbulence Research Management Plan (RMP). We describe in detail two candidate procedures, their operational variations and the expected capacity benefits at selected airports. The first procedure is a near-term proposed change to the 2500 foot runway centerline separation minimum for dependent approaches to two Closely Spaced Parallel Runways (CSPR). When visual separation can not be provided, the current FAA rule requires parallel runways spaced less than 2500 ft to be treated as a single runway. While in-trail wake separation standards are dependent on wake categories of the generating and encountering aircraft, this rule is not. This paper shows that, by refining this standard to reflect the wake generation differences of different weight classes, substantial capacity benefits may be possible. Variations on this procedure are analyzed to explore the sensitivity of the capacity benefits to the underlying assumptions. The second procedure is a mid-term proposed change to reduce wake constraints for departures from parallel runways spaced closer than 2500 ft using a short-term prognosis of crosswinds at and near the area of aircraft rotation. A brief outline is provided of activities planned during 2004 to advance towards the specific design and implementation of these procedures. Once such activity is additional wake data collection at St. Louis (STL).
Low Impedance ALD HfO2 Partially-Filled-Gap Flexural and Bulk MEMS Resonators Piezoresistively Detected for Distributed Mass Sensing (2017)

This paper reports the design and characterization of partially-filled-gap capacitive MEMS resonators for distributed mass sensing applications. By filling the gap with HfO2, the coupling coefficient between electrode-resonator increases by ×6.67 times and the motional resistance decreases by ×12 times in comparison with its counterpart in air. An improvement by a factor of ×5.6 in the Signal-To-Noise Ratio (SNR) for DC bias up to ×2.8 lower is accomplished by performing a piezoresistive detection instead of capacitive detection. Quality factor (Q) of 11,350 and motional resistances (Rm) of 926 Ω have been achieved for Parallel Beam Resonators (PBR) vibrating at 22.231 MHz. For the first time, ALD HfO2 partially-filled-gap MEMS resonators are proven to achieve inertial distributed mass sensitivities of the order of 4.28 kHz/pg for beam-type and 1.8k Hz/pg for disk resonators.
Abstract 4945: Project Survival: Engineering a phenomic and artificial intelligence driven precision medicine biomarker pipeline for pancreatic adenocarcinomas (2019)

Abstract Pancreatic cancer is a complex and dynamic disorder necessitating a comprehensive clinical design integrated with robust OMICS technologies and AI analytics to identify potential molecular and clinical signatures of diagnosis, progression, and treatment outcomes. Project Survival is a multisite prospective longitudinal study currently in the 4th year of a 6 year initiative of sampling and analysis of subjects in 6 categories: healthy volunteers with a first degree relative with pancreatic cancer (N=39), pancreatitis (N=34), pancreatic cystic neoplasm (N=52), suspicious pancreatic masses with pathology other than pancreatic cancer (N=22), early stage (N=66), locally advanced (N=123), and metastatic pancreatic cancer (N=99). All diseased patients are longitudinally sampled multiple times per year for sera, plasma, buffy coat, saliva, urine, and tumor/adjacent normal tissue. The BERG Interrogative Biology® platform is employed for multi-omic mass spectrometry analysis (metabolomics, lipidomics and proteomics) and applies artificial intelligence (bAIcis®, BERG Artificial Intelligence Clinical Information System) technologies. bAIcis® is harnessed to align the multi-omic profiles with longitudinal clinical information to infer probabilistic cause-and-effect relationships among molecular and clinical variables in a network-based model. Multiple longitudinal time points continue to be collected during the course of the six-year timeline enabling dynamic modeling. The value of this longitudinal study is in the epidemiological assessment of patient type progression to more advanced stages and identification of biomarkers and clinical features that align with the shifts observed in the patient populations. Collectively, we are incorporating patient progression with longitudinal sampling to investigate predictive signatures of disease advancement. Biomarker panels with AUC &amp;gt; 0.7 will be pursued in a further prospective clinical study with a larger subject number. The integration of multi-omic analysis with artificial intelligence has identified several biomarker panels that meet numerous unmet needs for the identification and clinical stratification of pancreatic adenocarcinoma. Citation Format: Eric Michael Grund, Michael A. Kiebish, Viatcheslav R. Akmaev, Rangaprasad Sarangarajan, John J. Crowley, Amy Stoll-D'Astice, Tori Singer, Corinne Decicco, Wendy Hori, Abena Darkwah, Lixia Zhang, Valerie Bussberg, Leonardo O. Rodrigues, Emily Y. Chen, Tomislav Dragovich, Manuel Hidalgo, Niven R. Narain, A James Moser. Project Survival: Engineering a phenomic and artificial intelligence driven precision medicine biomarker pipeline for pancreatic adenocarcinomas [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4945.
Tuning Single-Atom Electron Spin Resonance in a Vector-Magnetic Field (2019)

Spin resonance of single spin centers bears great potential for chemical structure analysis, quantum sensing and quantum coherent manipulation. Essential for these experiments is the presence of a two-level spin system whose energy splitting can be chosen by applying a magnetic field. In recent years, a combination of electron spin resonance (ESR) and scanning tunneling microscopy (STM) has been demonstrated as a technique to detect magnetic properties of single atoms on surfaces and to achieve sub-$μ$eV energy resolution. Nevertheless, up to now the role of the required magnetic fields has not been elucidated. Here, we perform single-atom ESR on individual Fe atoms adsorbed on magnesium oxide (MgO), using a 2D vector magnetic field as well as the local field of the magnetic STM tip in a commercially available STM. We show how the ESR amplitude can be greatly improved by optimizing the magnetic fields, revealing in particular an enhanced signal at large in-plane magnetic fields. Moreover, we demonstrate that the stray field from the magnetic STM tip is a versatile tool. We use it here to drive the electron spin more efficiently and to perform ESR measurements at constant frequency by employing tip-field sweeps. Lastly, we show that it is possible to perform ESR using only the tip field, under zero external magnetic field, which promises to make this technique available in many existing STM systems.
Differential Induction of TLR3-Dependent Innate Immune Signaling by Closely Related Parasite Species (2014)

The closely related protozoan parasites Toxoplasma gondii and Neospora caninum display similar life cycles, subcellular ultrastructure, invasion mechanisms, metabolic pathways, and genome organization, but differ in their host range and disease pathogenesis. Type II (γ) interferon has long been known to be the major mediator of innate and adaptive immunity to Toxoplasma infection, but genome-wide expression profiling of infected host cells indicates that Neospora is a potent activator of the type I (α/β) interferon pathways typically associated with antiviral responses. Infection of macrophages from mice with targeted deletions in various innate sensing genes demonstrates that host responses to Neospora are dependent on the toll-like receptor Tlr3 and the adapter protein Trif. Consistent with this observation, RNA from Neospora elicits TLR3-dependent type I interferon responses when targeted to the host endo-lysosomal system. Although live Toxoplasma fail to induce type I interferon, heat-killed parasites do trigger this response, albeit much weaker than Neospora, and co-infection studies reveal that T. gondii actively suppresses the production of type I interferon. These findings reveal that eukaryotic pathogens can be potent inducers of type I interferon and that related parasite species interact with this pathway in distinct ways.
Mixed hardware software multilevel modeling and simulation for multithreaded heterogeneous MPSoC (2007)

ISBN : 1-4244-0582-3
Improving Total Migration Time in Live Virtual Machine Migration (2015)

Virtualization is the key underlying technology enabling cloud providers to host services for a large number of customers. Live migration is an essential feature of virtualization that allows transfer of virtual machines from one physical server to another. Live migration facilitates workload balancing, fault tolerance, online system maintenance, consolidation of virtual machines etc. The pre-copy algorithm is the most used method for the live migration of virtual machines. One of the objectives of live migration is that it should have minimum migration time as well as downtime so that application running on VM will be suspended for negligible time. In this paper we proposed an algorithm to improve the total migration time which is modifies the existing counting Sort algorithm for the live Migration and time series based algorithm. This algorithm takes dirty counts of group of pages instead of individual dirty counts of each page and send those pages only which are not highly dirtied.
Culture is no Defense for Infanticide (2003)

CULTURE IS NO DE.ENSE .OR IN.ANTICIDE 977 when charged with a crime.However, culture by itself is not an adequate defense to killing a child.This Comment examines some recent cases of infanticide by Asian immigrants in which cultural defense played a role in how American courts dealt with this crime. 9 In analyzing the outcome of these cases and the recent use of culture as a criminal defense, this Comment argues that a childs right to live, and the particularly violent nature of infanticide, makes ones culture an inadequate defense.The cultural defense generally has no place in infanticide crimes because, despite differences in cultural attitudes toward the practice, the killing of children is not a legitimate activity in any culture.
Bulletin de la Société d'Ethnologie du Limousin, de La Marche et des régions voisines. Hôtel de Ville, Limoges (1963)

Robert Jean. Bulletin de la Société d'Ethnologie du Limousin, de La Marche et des régions voisines. Hôtel de Ville, Limoges. In: Norois, n°40, Octobre-Décembre 1963. p. 408.
<title>Wideband Adaptive Optics For Imaging</title> (1976)

To obtain high resolution images from large aperture optical systems, it is well known that the optical path must be corrected before the image is recorded and the phase information essentially lost. This predetection compensation requires fast response, adaptive optical elements in order to correct for optical path errors introduced by a turbulent atmospheric path. Fundamental concepts and operation of a laboratory system for wide band real time atmospheric compensation is discussed. The RTAC system operates closed-loop and automatically locks-in to correct phase aberrations of a rapidly varying turbulent atmosphere.
A Cross-sectional Study on Mobile Medical Applications and the Effectiveness of the Strategies Adopted to Promote Them (2017)

Introduction: Increase in the number of mobile medical applications (Apps) along with an increased sophistication of mobile technology resulted in an altered way of patient awareness and care. It is always challenging for an App developer to ensure the success of an App, hence the present study aims to identify and study the utilization promotional strategies for mobile medical Apps. Materials and Methods: A cross-sectional study was conducted on 150 mobile medical Apps. These were then comparatively evaluated for App information, technical parameters, and privacy permissions. The utilization of promotional strategies, user ratings, and number of downloads were presented descriptively. Results: App store listing and App store optimization, social sharing from inside networks, and keep App freemium were the top three strategies used for the promotion of the mobile medical Apps. Country-wise App ratings indicate that the UK Apps have considerably higher median value for high ratings followed by Australia and the USA. Higher percentage of downloads were seen among the mobile medical Apps developed by Australia, the USA, and the UK developers. Conclusion: Previous studies purely focused on the adherence of medical Apps, benefits of smartphones, and benefits of medical Apps, the effectiveness of promotional strategies on the acceptability of medical App is not available but the need of promoting the Apps was not available in this area. Present study was able to clearly indicate the promotional strategy utilization and was also demonstrated disparities in user rating and number of downloads across countries.
Purification and Characterization of Cannabidiolic-acid Synthase from Cannabis sativa L. (1996)

We identified a unique enzyme that catalyzes the oxidocyclization of cannabigerolic acid to cannabidiolic acid (CBDA) in Cannabis sativa L. (CBDA strain). The enzyme, named CBDA synthase, was purified to apparent homogeneity by a four-step procedure: ammonium sulfate precipitation followed by chromatography on DEAE-cellulose, phenyl-Sepharose CL-4B, and hydroxylapatite. The active enzyme consists of a single polypeptide with a molecular mass of 74 kDa and a pI of 6.1. The NH2-terminal amino acid sequence of CBDA synthase is similar to that of Delta1-tetrahydrocannabinolic-acid synthase. CBDA synthase does not require coenzymes, molecular oxygen, hydrogen peroxide, and metal ion cofactors for the oxidocyclization reaction. These results indicate that CBDA synthase is neither an oxygenase nor a peroxidase and that the enzymatic cyclization does not proceed via oxygenated intermediates. CBDA synthase catalyzes the formation of CBDA from cannabinerolic acid as well as cannabigerolic acid, although the kcat for the former (0.03 s-1) is lower than that for the latter (0.19 s-1). Therefore, we conclude that CBDA is predominantly biosynthesized from cannabigerolic acid rather than cannabinerolic acid.
Detection of Silicone in Lymph Node Biopsy Specimens by Near-Infrared Raman Spectroscopy (1993)

Near-infrared Raman spectroscopy with a 782-nm cw laser was used to examine lymph node biopsy specimens from women with ruptured breast implants containing silicone gel. For reduction of fluorescence and sample radiation damage, a low-power (30 mW) Ti: sapphire laser, single-stage spectrograph, and CCD detector were employed. Silicone Raman features were clearly visible in lymph node tissue of patients with leaking implants, and the spectra were easily distinguished from those of normal lymph node tissue. The technique has promise for medical diagnostic purposes, and may be amenable to in vivo analysis with adaptation to a fiber-optic probe.