gebhart/patrepeval huggingface dataset:
ChemInform Abstract: MS‐681a, b, c, and d, New Inhibitors of Myosin Light Chain Kinase from Myrothecium sp. Part 2. Physico‐Chemical Properties and Structure Elucidation. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Derivate der Thiosalicylsäure und des Thioxanthons (1909)

U i i l m n u n , nuch an dieser Stelle nieinen verbindlichsten Dank ~U Szusprechen.Die oben beschriebeiie Umlagerung
Effects of rSP-C Surfactant on Oxygenation and Histology in a Rat-Lung-Lavage Model of Acute Lung Injury (1998)

We have tested two surfactant preparations with the same phospholipid (PL) composition, containing recombinant surfactant protein-C (rSP-C surfactant) and without SP-C (plain PL surfactant). The effects of rSP-C surfactant were compared with the bovine-derived surfactant preparations Alveofact, bLES, and Infasurf in a lung lavage model, with surfactant given 1 h after the last lavage. The effects of surfactant treatment on histopathologic changes (e.g., hyaline-membrane formation) and improvement of oxygenation were compared with changes in untreated controls. The surfactants were given in doses of 25, 50, and 100 mg PL/kg body weight. At 120 min after treatment, only the protein-containing surfactants showed a statistically significant increasing dose dependence with respect to improving oxygenation. The values were 318 +/- 120 mm Hg, 443 +/- 58 mm Hg, and 480 +/- 43 mm Hg (mean +/- SD) for the three doses of rSP-C surfactant and 105 +/- 81 mm Hg, 100 +/- 69 mm Hg, and 131 +/- 108 mm Hg for the three doses of PL surfactant. The respective values for Alveofact were 104 +/- 81 mm Hg, 105 +/- 93 mm Hg, and 260 +/- 143 mm Hg; for bLES 373 +/- 138 mm Hg, 441 +/- 88 mm Hg, and 467 +/- 43 mm Hg; and for Infasurf 146 +/- 96 mm Hg, 284 +/- 178 mm Hg, and 436 +/- 70 mm Hg. The oxygen values of controls remained low, at 74 +/- 46 mm Hg. Only the protein-containing surfactants dose-dependently inhibited the formation of hyaline membranes. We conclude that rSP-C surfactant is at least as effective as bovine-derived surfactants. Furthermore, the data imply that the difference between plain PL surfactant preparations and bovine-derived surfactant preparations containing both SP-B and SP-C can be overcome by addition of SP-C.
Secure web service federation management using tpm virtualisation (2007)

Web Services and SOA provide interoperability and architectural baseline for flexible and dynamic cross enterprise collaborations, where execution and use of the participating services contributes to the common objective. Relationships within these collaborations are complex, with services joining and leaving throughout the life cycle, or the same services being offered in several collaborations simultaneously. This provides strong requirements for federated security, where integrity and confidentiality of the collaboration must be maintained through membership control, security policy enforcement and separation of web service instance interactions in different collaborations.
C-terminal domain of mammalian complexin-1 localizes to highly curved membranes (2016)

In presynaptic nerve terminals, complexin regulates spontaneous "mini" neurotransmitter release and activates Ca<sup>2+</sup>-triggered synchronized neurotransmitter release. We studied the role of the C-terminal domain of mammalian complexin in these processes using single-particle optical imaging and electrophysiology. The C-terminal domain is important for regulating spontaneous release in neuronal cultures and suppressing Ca<sup>2+</sup>-independent fusion in vitro, but it is not essential for evoked release in neuronal cultures and in vitro. This domain interacts with membranes in a curvature-dependent fashion similar to a previous study with worm complexin [Snead D, Wragg RT, Dittman JS, Eliezer D (2014) Membrane curvature sensing by the C-terminal domain of complexin. Nat Commun 5:4955]. The curvature-sensing value of the C-terminal domain is comparable to that of α-synuclein. Upon replacement of the C-terminal domain with membrane-localizing elements, preferential localization to the synaptic vesicle membrane, but not to the plasma membrane, results in suppression of spontaneous release in neurons. Membrane localization had no measurable effect on evoked postsynaptic currents of AMPA-type glutamate receptors, but mislocalization to the plasma membrane increases both the variability and the mean of the synchronous decay time constant of NMDA-type glutamate receptor evoked postsynaptic currents.
Smart AppStore: Expanding the Frontiers of Smartphone Ecosystems (2014)

Smart AppStore offers five important features for today's smartphone users: biometric authentication, multilevel authorization, gesture recognition and navigation, user-tailored reputation scores, and identity management. The Web extra at http://youtu.be/15KPOUp5H_A is a video demonstration of Smart AppStore, which offers five important features for today's smartphone users: biometric authentication, multilevel authorization, gesture recognition and navigation, user-tailored reputation scores, and identity management.
Dynamic Wetting on a Thin Film of Soluble Polymer: Effects of Nonlinearities in the Sorption Isotherm (2013)

The wetting dynamics of a solvent on a soluble substrate interestingly results from the rates of the solvent transfers into the substrate. When a supported film of a hydrosoluble polymer with thickness e is wet by a spreading droplet of water with instantaneous velocity U, the contact angle is measured to be inversely proportionate to the product of thickness and velocity, eU, over two decades. As for many hydrosoluble polymers, the polymer we used (a polysaccharide) has a strongly nonlinear sorption isotherm φ(a(w)), where φ is the volume fraction of water in the polymer and aw is the activity of water. For the first time, this nonlinearity is accounted for in the dynamics of water uptake by the substrate. Indeed, by measuring the water content in the polymer around the droplet φ at distances as small as 5 μm, we find that the hydration profile exhibits (i) a strongly distorted shape that results directly from the nonlinearities of the sorption isotherm and (ii) a cutoff length ξ below which the water content in the substrate varies very slowly. The nonlinearities in the sorption isotherm and the hydration at small distances from the line were not accounted for by Tay et al., Soft Matter 2011, 7, 6953. Here, we develop a comprehensive description of the hydration of the substrate ahead of the contact line that encompasses the two water transfers at stake: (i) the evaporation-condensation process by which water transfers into the substrate through the atmosphere by the condensation of the vapor phase, which is fed by the evaporation from the droplet itself, and (ii) the diffusion of liquid water along the polymer film. We find that the eU rescaling of the contact angle arises from the evaporation-condensation process at small distances. We demonstrate why it is not modified by the second process.
Characterization of the ganglioside recognition profile of Escherichia coli heat-labile enterotoxin LT-IIc (2021)

The heat-labile enterotoxins of Escherichia coli and cholera toxin of Vibrio cholerae are related in structure and function. Each of these oligomeric toxins is comprised of one A polypeptide and five B polypeptides. The B-subunits bind to gangliosides, which are followed by uptake into the intoxicated cell and activation of the host's adenylate cyclase by the A-subunits. There are two antigenically distinct groups of these toxins. Group I includes cholera toxin and type I heat-labile enterotoxin of E. coli; group II contains the type II heat-labile enterotoxins of E. coli. Three variants of type II toxins, designated LT-IIa, LT-IIb and LT-IIc have been described. Earlier studies revealed the crystalline structure of LT-IIb. Herein the carbohydrate binding specificity of LT-IIc B-subunits was investigated by glycosphingolipid binding studies on thin-layer chromatograms and in microtiter wells. Binding studies using a large variety of glycosphingolipids showed that LT-IIc binds with high affinity to gangliosides with a terminal Neu5Acα3Gal or Neu5Gcα3Gal, e.g. the gangliosides GM3, GD1a and Neu5Acα3-/Neu5Gcα3--neolactotetraosylceramide and Neu5Acα3-/Neu5Gcα3-neolactohexaosylceramide. The crystal structure of LT-IIc B-subunits alone and with bound LSTd/sialyl-lacto-N-neotetraose d pentasaccharide uncovered the molecular basis of the ganglioside recognition. These studies revealed common and unique functional structures of the type II family of heat-labile enterotoxins.
ChemInform Abstract: α‐Hydroxylation of 1,3‐Dicarbonyl Compounds Catalyzed by Polymer‐Incarcerated Gold Nanoclusters with Molecular Oxygen. (2013)

Abstract α‐Hydroxylation of 1,3‐dicarbonyl compounds is successfully catalyzed by carbon‐stabilized polymer‐incarcerated gold nanoclusters.
Boundary sliding mode controller design for supercavitating vehicles (2017)

Supercavitating vehicles have special characteristics from traditional underwater vehicles because of supercavitation. Due to the nonlinear planing force, parameter uncertainty behavior of the system, the uncontrolled system is unstable, and the controller design is challenged. Sliding mode controller is anti-interference and robust. To improve the stability of the system, the robust sliding mode controller based on upperlower boundary is designed. Meanwhile, the planing force is estimated as disturbance. The stability of the system is verificated by Lyapunov theory. Simulation result show that the controller is effective and the system is robustness.
Ribosome conformational changes associated with protein S6 phosphorylation. (1984)

The relative accessibility of rat liver ribosomal proteins to reductive methylation was examined using ribosomes with unphosphorylated, and extensively phosphorylated S6. Comparison of the results indicated that proteins S3, S4, S7, and S23/24 of the small subunit, and proteins L9, L10, L12, L18, L27, L34, and L36 are involved in a ribosomal conformational change.
Elucidation of the RNA Recognition Code for Pentatricopeptide Repeat Proteins Involved in Organelle RNA Editing in Plants (2013)

Pentatricopeptide repeat (PPR) proteins are eukaryotic RNA-binding proteins that are commonly found in plants. Organelle transcript processing and stability are mediated by PPR proteins in a gene-specific manner through recognition by tandem arrays of degenerate 35-amino-acid repeating units, the PPR motifs. However, the sequence-specific RNA recognition mechanism of the PPR protein remains largely unknown. Here, we show the principle underlying RNA recognition for PPR proteins involved in RNA editing. The distance between the PPR-RNA alignment and the editable C was shown to be conserved. Amino acid variation at 3 particular positions within the motif determined recognition of a specific RNA in a programmable manner, with a 1-motif to 1-nucleotide correspondence, with no gap sequence. Data from the decoded nucleotide frequencies for these 3 amino acids were used to assign accurate interacting sites to several PPR proteins for RNA editing and to predict the target site for an uncharacterized PPR protein.
3D facial expression recognition with geometrically localized facial features (2008)

This paper describes a pose invariant three-dimensional (3D) facial expression recognition method using distance vectors retrieved from 3D distributions of facial feature points to classify universal facial expressions. Probabilistic Neural Network architecture is employed as a classifier to recognize the facial expressions from a distance vector obtained from 3D facial feature locations. Facial expressions such as anger, sadness, surprise, joy, disgust, fear and neutral are successfully recognized with an average recognition rate of 87.8%.
Nicolaides–Baraitser syndrome: Delineation of the phenotype (2009)

Nicolaides-Baraitser syndrome (NBS) is an infrequently described condition, thus far reported in five cases. In order to delineate the phenotype and its natural history in more detail, we gathered data on 18 hitherto unreported patients through a multi-center collaborative study, and follow-up data of the earlier reported patients. A detailed comparison of the 23 patients is provided. NBS is a distinct and recognizable entity, and probably has been underdiagnosed until now. Main clinical features are severe mental retardation with absent or limited speech, seizures, short stature, sparse hair, typical facial characteristics, brachydactyly, prominent finger joints and broad distal phalanges. Some of the features are progressive with time. The main differential diagnosis is Coffin-Siris syndrome. There is no important gender difference in occurrence and frequency of the syndrome, and all cases have been sporadic thus far. Microarray analysis performed in 14 of the patients gave normal results. Except for the progressive nature there are no clues to the cause.
Facility Standards and Layout Typology of Temporary Shelters in Response to Disasters - Focused on Size Standard and Block Layout of Public Facilities - (2019)

국지적인 재난 상황이 지속적으로 발생하고 있으며, 장기적인 임시주거 운용의 필요성이 제기되고 있다. 그럼에도 임시주거 계획연구는 개별 유닛 연구와 대공간 내부 공간계획에 집중되고 있어 대규모 부지에 임시주거를 배치하기 위한 기본연구가 요구된다. 본 논문은 대규모 임시주거 계획에 필요한 규모 검토 및 배치 계획을 수립하기 위한 공용시설 설치 기준과 배치 유형을 개발하여 향후 대규모 단지 배치 가이드라인 구축을 위한 기본 자료로 활용하는 것을 목적으로 한다. 이를 위해서 국내임시주거 운용 체계를 기반으로 대규모 임시주거 운영의 경험이 있는 국제기구들의 공용시설 유형을 우선 선별하고, 국제기구 및 국내 유사 시설 설치기준을 준용하여 규모기준을 정립하였다. 격자 그리드형, 커뮤니티 가로형, 중앙 광장형의 기본 유형을 커뮤티니-블록 단위 7개의 유형을 개발하고, 이를 국내 학교 운동장 및 국제기구 기준 블록 규모를 수용할 수 있는 가상의 대지에 적용하여 설치 운용 효율성, 프라이버시, 공동체성 형성의 기준으로 유형별 특성 상호 비교 하였다. 각 유형은 재난발생 대응 시기별로 상보적으로 운용될 수 있을 것으로 판단된다.Local-level disasters continue to occur, which requires for long-term temporary housing operations. However, most researches on temporary housing planning have concentrated on individual units and space planning in large indoor spaces. The purpose of this paper is to develop the installation criteria and layout typology for public facilities. Based on the domestic system of temporary housing management, the types of public facilities were established by comparing the guidelines by international organizations with domestic standards. This research developed seven models of community-block layout based on grid distribution, community road, and center squares, and applied them to a virtual site that can accommodate the block size of domestic school grounds and the size standard of international organizations. The characteristics of each model were compared by three criteria including convenience of installation and distribution, privacy and community building. Each facility type can be utilized as a complementary to each other, according to a long-term disaster response scenario.
The Effect of Moisture Content on the Conversion of Ergosterol to Vitamin D in Shiitake Mushrooms (2003)

10.1081/DRT-120021876
Broadband Balun Using Fully Artificial Fractal-Shaped Composite Right/Left Handed Transmission Line (2011)

In this letter, a compact balun with bandwidth enhancement is firstly proposed based on fully artificial fractal-shaped composite right/left handed transmission line (CRLH TL). It consists of three -90° CRLH branches and one +90° CRLH branch. The left handed contribution is realized by chip components while the right handed part is exploited by fractal microstriplines in terms of miniaturization. For verification, a balun operating at 1.5 GHz is designed, fabricated, and measured. Numerical and measured results agree well, which has confirmed the design concept and the derived formulae. The fabricated balun exhibits a bandwidth of 83.3% from 1 to 2.25 GHz, characterized by return loss better than 10 dB, amplitude and phase imbalance varied within ±1 dB and ±3.4°. Moreover, the circuit footprint is only 24.5% of the area that its conventional counterpart occupies.
In vitro synergistic activity of the sulbactam/avibactam combination against extensively drug-resistant Acinetobacter baumannii (2020)

<b>Introduction.</b> The therapeutic options to treat <i>Acinetobacter baumannii</i> infections are very limited.<b>Aim.</b> Our aim was to evaluate the activity of sulbactam combined directly with avibactam or the ampicillin-sulbactam/ceftazidime-avibactam combination against extensively drug-resistant <i>A. baumannii</i> isolates.<b>Methodology.</b> Extensively drug-resistant <i>A. baumannii</i> isolates (<i>n</i>=127) collected at several South American hospitals were studied. Synergy with the sulbactam/avibactam combination was assessed in all isolates using the agar dilution method. Avibactam was used at a fixed concentration of 4 mg l<sup>-1</sup>. A disc diffusion synergy test was also performed. Synergy by a time-kill experiment was performed in a selected isolate.<b>Results.</b> Synergy with sulbactam/avibactam was demonstrated in 124 isolates and it showed MIC values ≤4 mg l<sup>-1</sup>. This synergy was not detected in the three New Delhi metallo-β-lactamase-harbouring isolates. Similar results were observed with the disc diffusion synergy test of ampicillin-sulbactam/ceftazidime-avibactam. In the time-kill experiments, sulbactam/avibactam showed a rapid synergistic and bactericidal activity in ampicillin-sulbactam-resistant isolates.<b>Conclusions.</b> This study demonstrated that the sulbactam/avibactam combination displayed synergistic activity against <i>A. baumannii</i> isolates. This synergy was observed when both inhibitors were also used as part of the commercially available combinations: ampicillin-sulbactam and ceftazidime-avibactam.
User-Guided Domain Adaptation for Rapid Annotation from User\n Interactions: A Study on Pathological Liver Segmentation (2020)

Mask-based annotation of medical images, especially for 3D data, is a\nbottleneck in developing reliable machine learning models. Using minimal-labor\nuser interactions (UIs) to guide the annotation is promising, but challenges\nremain on best harmonizing the mask prediction with the UIs. To address this,\nwe propose the user-guided domain adaptation (UGDA) framework, which uses\nprediction-based adversarial domain adaptation (PADA) to model the combined\ndistribution of UIs and mask predictions. The UIs are then used as anchors to\nguide and align the mask prediction. Importantly, UGDA can both learn from\nunlabelled data and also model the high-level semantic meaning behind different\nUIs. We test UGDA on annotating pathological livers using a clinically\ncomprehensive dataset of 927 patient studies. Using only extreme-point UIs, we\nachieve a mean (worst-case) performance of 96.1%(94.9%), compared to 93.0%\n(87.0%) for deep extreme points (DEXTR). Furthermore, we also show UGDA can\nretain this state-of-the-art performance even when only seeing a fraction of\navailable UIs, demonstrating an ability for robust and reliable UI-guided\nsegmentation with extremely minimal labor demands.\n
TiN/AlN ceramic substrates for high temperature power electronics applications (2012)

International audience
Precursor proteins are transported into mitochondria in the absence of proteolytic cleavage of the additional sequences. (1983)

Many nuclear-coded mitochondrial proteins are synthesized as larger precursor polypeptides that are proteolytically processed during import into the mitochondrion. This processing appears to be catalyzed by a soluble, metal-dependent protease localized in the mitochondrial matrix. In this report we employ an in vitro system to investigate the role of processing in protein import. Intact Neurospora crassa mitochondria were incubated with radiolabeled precursors in the presence of the chelator o-phenanthroline. Under these conditions, the processing of the precursors of the beta-subunit of F1-ATPase (F1 beta) and subunit 9 of the F0F1-ATPase was strongly inhibited. Protease-mapping studies indicated that import of the precursor proteins into the mitochondria continued in the absence of processing. Upon readdition of divalent metal to the treated mitochondria, the imported precursors were quantitatively converted to their mature forms. This processing of imported precursors occurred in the absence of a mitochondrial membrane potential and was extremely rapid even at 0 degrees C. This suggests that all or part of the polypeptide chain of the imported precursors had been translocated into the matrix location of the processing enzyme. Localization experiments suggested that the precursor to F1 beta is peripherally associated with the mitochondrial membrane while the precursor to subunit 9 appeared to be tightly bound to the membrane. We conclude that proteolytic processing is not necessary for the translocation of precursor proteins across mitochondrial membranes, but rather occurs subsequent to this event. On the basis of these and other results, a hypothetical pathway for the import of F1 beta and subunit 9 is proposed.
Adolescent obesity and bariatric surgery (2009)

Morbid obesity in adolescents has severe acute and chronic complications. Bariatric surgery in adolescents seems as well tolerated as in adults when performed in centers with appropriate experience and adequate surgical volume. The pathophysiologic implications of bariatric surgery are profound. A better understanding of the mechanisms leading to postsurgical improvement in insulin resistance and weight loss could lead to the development of other therapies to achieve the same effects with lesser morbidities.
The Primordial Inflation Polarization Explorer (PIPER) (2016)

The Primordial Inflation Polarization ExploreR (PIPER) is a balloon-borne telescope designed to measure the polarization of the Cosmic Microwave Background on large angular scales. PIPER will map 85% of the sky at 200, 270, 350, and 600 GHz over a series of 8 conventional balloon flights from the northern and southern hemispheres. The first science flight will use two 32 × 40 arrays of backshort-under-grid transition edge sensors, multiplexed in the time domain, and maintained at 100 mK by a Continuous Adiabatic Demagnetization Refrigerator. Front- end cryogenic Variable-delay Polarization Modulators provide systematic control by rotating linear to circular polarization at 3 Hz. Twin telescopes allow PIPER to measure Stokes I, Q, U , and V simultaneously. The telescope is maintained at 1.5 K in an LHe bucket dewar. Cold optics and the lack of a warm window permit sensitivity at the sky-background limit. The ultimate science target is a limit on the tensor-to-scalar ratio of r ∼ 0.007, from the reionization bump to l ∼ 300. PIPER’s first flight will be from the Northern hemisphere, and overlap with the CLASS survey at lower frequencies. We describe the current status of the PIPER instrument.
Implementations Supporting Automated Technology Transfer in MDE as a Service (2019)

Coopetition characterizes scenarios where competing firms establish collaborations for some intent. Here applies foundational studies built on software reuse and asset standards, such as for OSLC and RAS, asset platforms, smart contracts and others that are essential for promoting coopetition in the area. Our contribution is an experience report that provide foundations for technology transfer to software factory coopetition scenarios. Our goal is to characterize some coopetition approaches and tool support assisting Software Engineering (SE) tasks for technology transfer. This paper presents an experience report analyzing multi-case studies, implemented in local scenarios for coopetition, characterizing the research area with a summary of the main findings. The presented results are twofold: 1) With the current tool support in the state-of-the art, automation of SE tasks for technology transfer is feasible to local scenarios; and 2) However, global coopetition scenarios impose new implementation barriers.