gebhart/patrepeval huggingface dataset:
Serum and Cerebrospinal Fluid Uric Acid Levels in Lewy Body Disorders: Associations with Disease Occurrence and Amyloid-β Pathway (2011)

Recent studies have provided evidence that uric acid (UA), a natural antioxidant, may play a role in the development and progression of Parkinson's disease (PD) and of dementia. In this clinical study we were therefore interested in the role of UA in Lewy body disorders (LBD), which includes Parkinson's disease (PD) and a common form of neurodegenerative dementias, dementia with Lewy bodies (DLB). Ninety-five LBD patients (55 non-demented PD patients, PDND; 20 PD patients with dementia, PDD; and 20 DLB patients) and 76 controls underwent clinical and biochemical analyses including, from a subcohort, cerebrospinal fluid (CSF) analyses, and analysis of three single nucleotide polymorphisms (SNPs) known to be associated with altered serum UA levels. We confirmed previous findings of lowered serum UA levels in LBD patients compared to controls. In CSF, UA levels were significantly higher in PDND patients (median 0.7 mg/dl) compared only to demented LBD patients (0.4 mg/dl; p = 0.03), but not to controls (0.5 mg/dl; p = 0.12). CSF UA levels correlated positively with CSF Aβ42 levels. This correlation was highest in controls (ρ = 0.67), intermediate in PDND (ρ = 0.49), but not observable in demented LBD patients (ρ = 0.10). These findings suggest an involvement of serum UA in LBD occurrence, and an involvement of CSF UA in cognitive decline in LBD, possibly through the Aβ pathway. SNP rs1165205 (SLC17A3) was weakly associated with altered CSF UA levels. Taken together, our results provide first evidence for disease-relevant but potentially distinct roles of UA in the blood and CSF compartment, respectively, in LBD.
Endoscopic vacuum therapy in the management of anastomotic insufficiency after pancreaticoduodenectomy (2012)

A 68-year-old patient with a pT3pN2 duodenal adenocarcinoma underwent pancreaticoduodenectomy. Because the jejunal loop was anastomosed with a previous gastroenterostomy, endoscopic examination of the pancreatic and biliary anastomoses was easily feasible. On the 5th postoperative day, the patient developed septic shock and multiorgan failure; bilious secretions were noted coming from the abdominal drains. An immediate revision laparotomy was performed, at which generalized peritonitis was found. It was associated with total dehiscence of the biliojejunal anastomosis and subtotal dehiscence of the pancreaticojejunal anastomosis. Operative reconstruction of the anastomoses was impossible. Four laparotomies with lavage of the peritoneal cavity were scheduled at 48-hour intervals. During this time, an acute hepatic artery bleed caused by septic erosion occurred.
Fast chromatin immunoprecipitation assay (2006)

Chromatin immunoprecipitation (ChIP) is a widely used method to explore in vivo interactions between proteins and DNA. The ChIP assay takes several days to complete, involves several tube transfers and uses either phenol-chlorophorm or spin columns to purify DNA. The traditional ChIP method becomes a challenge when handling multiple samples. We have developed an efficient and rapid Chelex resin-based ChIP procedure that dramatically reduces time of the assay and uses only a single tube to isolate PCR-ready DNA. This method greatly facilitates the probing of chromatin changes over many time points with several antibodies in one experiment.
Characterization of thulium- and holmium-doped YAG ceramic laser materials (2006)

Thulium and holmium-doped yttrium aluminum garnet (YAG) ceramic materials are investigated. Compared with YAG crystal, there is hardly any spectroscopic difference between ceramic and crystal at the same doping level. Laser oscillation was successfully carried out under quasicontinuous- wave diode pumping. Optical-to-optical efficiency higher than 5% was achieved. It was calculated that total absorbed power hardly changes around 783 nm with a bandwidth of about 7 nm using a diode array of 3.5-nm linewidth as a pump source.
Impact of Different Green Manures on the Content ofS-Alk(en)yl-l-cysteine Sulfoxides andl-Ascorbic Acid in Leek (Allium porrum) (2008)

This field study investigated the impact of various fertilization strategies with red clover ( Trifolium pratense L.) green manure on the levels of S-alk(en)yl- l-cysteine sulfoxides (ACSO) and l-ascorbic acid in leek. Two of the 12 treatments were controls, one without fertilizers and the other with a commercial mineral fertilizer. The remaining 10 treatments were different forms and quantities of green manure prepared from red clover. One treatment consisted of direct incorporation into soil of the preceding red clover crop. The other 9 treatments comprised three types of red clover green manure [anaerobically digested red clover biomass (biodigestate), composted red clover, fresh red clover as mulch] applied at three different doses. Yield was increased only at the highest dose of compost and the highest dose of mulch. High doses of green manure decreased dry matter content in leek. The fertilizer treatments increased the nitrogen uptake and the nitrogen content of leek. Sulfur uptake and sulfur levels were increased only by the mineral fertilizer and by the compost. Nonfertilized leek contained 20.4 +/- 5.8 g/kg of dry weight (dw) ACSOs as determined by LC-MS/MS and 1.57 +/- 0.01 g/kg of dw ascorbic acid as determined by HPLC. The ACSOs were to 92-96% isoalliin, the rest being methiin. Alliin was identified in only 1 of 72 samples. The ACSO level was increased by 37% by the mineral fertilizer. Whereas direct incorporation of red clover, mulch, and red clover biodigestate had no influence on the ACSO level, the highest dose of compost increased the ACSO level by 55%. Ascorbic acid levels were not influenced by the mineral treatment. Green manures increased ascorbic acid levels only on a dry weight basis. A high correlation between the content of sulfur and ACSO indicated that delivering capacity of sulfur from the manure to the plant strongly affected the ASCO content of the leek. In conclusion, the composted green manure was the most useful organic fertilizer in this study and reached at least the efficiency of the mineral fertilizer.
Polymer Chain Dynamics in Solution Probed with a Fluorescence Blob Model (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Six New Isolates of Human Immunodeficiency Virus Type 2 (HIV-2) and the Molecular Characterization of One (HIV-2CAM2) (1989)

We report the isolation of human immunodeficiency virus type 2 (HIV-2) from each of six West Africans with AIDS-related complex or AIDS. One isolate (HIV-2CAM2) was molecularly cloned and shown by restriction mapping to differ in seven out of 22 sites from the prototype HIV-2ROD. Nevertheless, by a number of serological criteria these isolates are all clearly HIV-2.
Practical Route to Introduce Lexitropsins Possessing A Natural Trisulfide Linker; Synthesis of N-(Lexitropsinthiosulfenyl) phthalimides (1998)

Article Practical Route to Introduce Lexitropsins Possessing A Natural Trisulfide Linker; Synthesis of N-(Lexitropsinthiosulfenyl) phthalimides was published on December 1, 1998 in the journal Heterocyclic Communications (volume 4, issue 6).
Integrative Analysis of Many Biological Networks to Study Gene Regulation (2015)

Gene expression is a complex process regulated and coordinated through the interactions of cellular components. In recent years, there has been an increasing accumulation of high-throughput biological network data characterizing these interactions at multiple levels and under different conditions and perturbations. Integrative analysis of many such networks is an important means of understanding the complexity of gene regulation. Therefore, there is an urgent need for powerful integrative methods capable of analyzing many biological networks simultaneously. In this chapter, we review three state-of-the-art studies that develop computational methods for identifying three types of patterns in multiple networks: transciptional modules, splicing modules, and coupled transcription-splicing modules. The atlas of these modules facilitates understanding of gene regulation processes, through reconstructing transcriptional regulatory networks, splicing regulatory networks, and exploring how transcription and splicing simultaneously take place.
Deep SimNets (2016)

We present a deep layered architecture that generalizes convolutional neural networks (ConvNets). The architecture, called SimNets, is driven by two operators: (i) a similarity function that generalizes inner-product, and (ii) a log-mean-exp function called MEX that generalizes maximum and average. The two operators applied in succession give rise to a standard neuron but in space. The feature spaces realized by SimNets depend on the choice of the similarity operator. The simplest setting, which corresponds to a convolution, realizes the feature space of the Exponential kernel, while other settings realize feature spaces of more powerful kernels (Generalized Gaussian, which includes as special cases RBF and Laplacian), or even dynamically learned feature spaces (Generalized Multiple Kernel Learning). As a result, the SimNet contains a higher abstraction level compared to a traditional ConvNet. We argue that enhanced expressiveness is important when the networks are small due to run-time constraints (such as those imposed by mobile applications). Empirical evaluation validates the superior expressiveness of SimNets, showing a significant gain in accuracy over ConvNets when computational resources at run-time are limited. We also show that in large-scale settings, where computational complexity is less of a concern, the additional capacity of SimNets can be controlled with proper regularization, yielding accuracies comparable to state of the art ConvNets.
Enforcing State Constraints on a Model of a Hypersonic Vehicle (2016)

Inlet unstart is a sudden breakdown of the shock system in an inlet which can lead to departure from controlled flight and sometimes catastrophic loss of supersonic and hypersonic air vehicles. One way to mitigate this problem is to limit the angle-of-attack and sideslip angle that a vehicle can achieve during flight. This paper develops a sliding mode adaptive controller with the ability to enforce state constraints, which makes it particularly useful for hypersonic vehicles. The system tracks a reference trajectory command provided that the command remains within a predetermined, acceptable region of the state-space. When the reference model leaves this region, the adaptive mechanism is “shut off” and replaced by a state limiting mechanism. An advantage of this approach is that no bounds need to be placed on the input command signal. This method is first developed for a general class of nonlinear dynamic systems of the same form as the equations of motion for a hypersonic vehicle. Controller performance is then demonstrated on a high fidelity simulation of a generic hypersonic vehicle. Results presented in the paper show that this controller is capable of constraining the states while maintaining a smooth control signal and can be considered as a potential candidate for prevention of inlet unstart.
Reactive Oxygen Species Involved in Phenazine-Methosulfate-Induced Rat Lens Opacification (1994)

The excised rat crystalline lens opacified when incubated aerobically with phenazine methosulfate, but no opacification was observed under anaerobic conditions. Morphological studies revealed development of opacification in the cortex. The opacification resembled that often seen in the early period of senile cataract as well as in naphthalene-induced and UV cataract. Both an increase in hydration and in electrolyte imbalance accompanied this opacification. Na,K-ATPase activity of the opacified lens was found to decrease. In order to investigate if activated oxygen is involved in these processes, we conducted an electron spin resonance study by means of a spin trapping technique. When the lens homogate was incubated with phenazine methosulfate, OH radicals were generated under aerobic but not under anaerobic conditions. Reduced pyridine nucleotides must be involved in the process, because the mixture of nicotinamide adenine dinucleotide phosphate [NAD(P)] and phenazine methosulfate did not generate OH radicals, but the mixture of NAD(P)H and phenazine methosulfate generates OH radicals, indicating that reduced phenazine methosulfate was involved in the OH radical generation. Probably, the generated OH radicals inactivated Na,K-ATPase residing in the epithelium of the lens, which eventually caused opacification of the lens. The present experiment system may be used for the elucidation of lens opacification (cataract) involved with reactive oxygen species.
XPS investigation of anodic oxides grown on p‐type InP (1990)

Abstract Chemical composition of anodic oxides grown on lightly doped p‐type InP have been investigated by XPS. Anodization was performed in the constant current density ( J c ) mode using an ortho‐phosphoric acid solution mixed with acetonitrile (ACN). The electrolyte was chosen after experimentation on the effect of the anodization parameters (electrolyte, viscosity of the electrolyte and pH, J c and illumination level) and annealing conditions on the uniformity and stability of the oxide and the contamination level, as determined by SEM/EDAX, SIMS and XPS. Based on our XPS investigation, it appears that the inhomogeneity with depth of the anodic oxides grown on p‐type InP is strongly dependent on the growth conditions. Depending on the anodization procedure, the anodic oxide appears complex and the presence of In(OH) 3 , In 2 O 3 , InPO 4 , In(PO 3 ) 3 , In(PO 3 ) 4 and other non‐stoichiometric In(PO y ) x compounds have been identified. Depending on the anodization conditions, it appears that both amorphous and crystalline phosphorus‐rich condensed phosphates, of interest for surface passivation of InP, can be grown on p‐type InP.
Nichtrauchen, ein Essential für eine gesunde Lunge. Raucherentwöhnung ist die wichtigste Präventionsmaßnahme überhaupt (2008)

Abstract Rauchen ist das größte Einzelrisiko in unserem Leben. Aufgrund des extremen gesundheitlichen Risikos des Rauchens ist die Behandlung der Tabakabhängigkeit die wichtigste Präventionsmaßnahme überhaupt. Für die Verhaltenstherapie wird nach einem Jahr eine Tabak‐Abstinenzrate von ca. 13 % angegeben. Die Abstinenzraten nach einem Jahr betragen für Placebo ca. 8 %, für Nicotinersatztherapie ca. 14 %, für Bupropion ca. 16 % und für Vareniclin ca. 22 %. Damit sind gegenüber Placebo bzw. keiner Medikation die 1‐Jahres‐Abstinenzraten für Nicotinersatztherapie um das ca. 1,8‐fache, für die Behandlung mit Bupropion um das ca. 2‐fache und für die Vareniclin‐Behandlung um das ca. 2,8‐fache erhöht. Durch intensive Beratung des Rauchers können die Abstinenzraten weiter verbessert werden. Alle Neben‐ und Wechselwirkungen sind vor dem Hintergrund zu sehen, dass Weiterrauchen das alles übertreffende Risiko ist. In Deutschland sterben täglich mindestens 300 Menschen an den Folgen des Rauchens.
Fermi surface resonance and quantum criticality in strongly interacting Fermi gases (2021)

Fermions in a Fermi gas obey the Pauli exclusion principle restricting any two fermions from occupying the same quantum state. Strong interactions between fermions can completely change the properties of the Fermi gas. In our theoretical study we find an exotic quantum phase in strongly interacting Fermi gases subject to a certain condition imposed on the Fermi surfaces that we call the Fermi surface resonance. The phase is quantum critical in time and space and can be identified by the power-law dependence of the spectral density in frequency and momentum. The linear-response functions are singular in the static limit and at the Kohn anomalies. We analyze the quantum critical state at finite temperatures $T$ and finite size $L$ of the Fermi gas and provide a qualitative $L\ensuremath{-}T$ phase diagram. The quantum critical phase can be experimentally found in typical semiconductor heterostructures.
The F-buffer (2001)

Multi-pass rendering is a common method of virtualizing graphics hardware to overcome limited resources. Most current multi-pass rendering techniques use the RGBA framebuffer to store intermediate results between each pass. This method of storing intermediate results makes it difficult to correctly render partially-transparent surfaces, and reduces the performance of shaders that need to preserve more than one intermediate result between passes. We propose an alternative approach to storing intermediate results that solves these problems. This approach stores intermediate colors (or other values) that are generated by a rendering pass in a FIFO buffer as the values exit the fragment pipeline. On a subsequent pass, the contents of the FIFO buffer are fed into the top of the fragment pipeline. We refer to this FIFO buffer as a fragment-stream buffer (or F-buffer), because this approach has the effect of associating intermediate results with particular rasterization fragments, rather than with an (x,y) location in the framebuffer. Implementing an F-buffer requires some changes to current mainstream graphics architectures, but these changes can be minor. We describe the design space associated with implementing an F-buffer, and compare the F-buffer to recirculating pipeline designs. We implement F-buffers in the Mesa software renderer, and demonstrate our programmable-shading system running on top of this renderer.
Studies in biomimetic alkaloid syntheses. 8. Total syntheses of the C-14 epimeric hydroxyvincadifformines, tabersonine, a (hydroxymethyl)-D-norvincadifformine and the C-20 epimeric pandolines (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies in biomimetic alkaloid syntheses. 8. Total syntheses of the C-14 epimeric hydroxyvincadifformines, tabersonine, a (hydroxymethyl)-D-norvincadifformine and the C-20 epimeric pandolinesMartin E. Kuehne, F. J. Okuniewicz, C. L. Kirkemo, and J. C. BohnertCite this: J. Org. Chem. 1982, 47, 7, 1335–1343Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://doi.org/10.1021/jo00346a034RIGHTS & PERMISSIONSArticle Views594Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Change in Mitochondrial Membrane Potential in Peripheral Blood Lymphocytes, Especially in Natural Killer Cells, Is a Possible Marker for Surgical Stress on the Immune System (2003)

There is accumulating evidence that surgical stresses cause impairment of systemic immune responses, which may promote susceptibility to infection as well as growth of remnant cancer cells in cancer patients. Although alterations in numbers, populations, and functions of lymphocytes have been extensively studied to assess modulation of the immune system, the precise mechanisms of immunosuppression caused by surgical stresses have not been identified, nor have methods been developed to estimate the magnitude of surgical stresses on the immune system. In the present study, to evaluate the effects of surgical procedures on the immune system, the mitochondrial membrane potential (Delta Psi(m)) of peripheral blood lymphocytes (PBL) from 25 patients who underwent various types of operation was measured by flow cytometry using 3,3'-dihexiloxacarbocyanine iodide (DiOC(6)(3)) on the day before operation and on postoperative day (POD) 1, POD 3, and POD 7. The Delta Psi(m) in PBL, especially in natural killer (NK) cell population, was reduced after major surgery. In particular, the reduction of Psi Delta(m) in NK cells appeared to be proportional to the severity of the surgical procedures and reflected the impairment of cellular function. Interestingly, the Delta Psi(m) in NK cells was also negatively correlated with the level of plasma noradrenaline after major surgery, suggesting that the reduction of Delta Psi(m) in NK cells induced by surgical stresses may be mediated, at least in part, by the accompanying increase in plasma noradrenaline. Monitoring of Delta Psi(m) in PBL after operation may be one of the useful markers for estimating the magnitude of surgical stresses on the immune system.
Thermal Lensing and Multiwatt Microchip Laser Operation of Yb:YCOB Crystals (2016)

Thermal lensing is studied in monoclinic Yb:Ca <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> YO(BO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ) <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (Yb: YCOB) oxoborate crystals cut along the optical indicatrix axes. For all orientations, the thermal lens is positive. In the Z-cut crystal, the sensitivity factors of the thermal lens are M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Z-X</sub> = 2.4 and M <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Z-Y</sub> = 2.8 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> /W (for E∥X), and the astigmatism degree is as low as S/M = 14%. The positive thermal lens in Yb:YCOB is related to the large thermal expansion and strong photoelastic effect. Microchip lasers are realized with 3-mm-long X, Y, and Z-cut 15 at.% Yb:YCOB crystals. With a Z-cut crystal, maximum output power of 8.35 W is achieved at ~1040 nm with slope efficiency of 70%. Using various crystal cuts and output coupler transmissions, multiwatt emission in the spectral range of 1033-1091 nm is demonstrated.
Evaluation of an expectation and outcome measurement questionnaire in ankle fracture patients: The Trauma Expectation Factor Trauma Outcomes Measure (TEFTOM) Eurasia study (2020)

TEFTOM demonstrated good psychometric properties in this cohort of patients with ankle fractures. The TEF 'expectation' score was predictive of the TOM 'outcome' score. We recommend researchers and clinicians to utilize TEFTOM when patient expectation measurement is concerned for orthopaedic trauma patients.