gebhart/patrepeval huggingface dataset:
Experience with Single Cavity and Piezo Controls for Short, Long Pulse and CW Operation (2017)

We present a compact RF control system for SCRF single cavities based on MicroTCA.4 equipped with specialized advanced mezzanine cards (AMCs) and rear transition modules (RTMs). To sense the RF signals from the cavity and to drive the high power source, a DRTM-DWC8VM1 module is used equipped with 8 analog field detectors and one RF vector modulator. Fast cavity frequency tuning is achieved by piezo-actuators attached to the cavity and a RTM piezo-driver module (DRTM-PZT4). Data processing of the RF signals and the real-time control algorithms are implemented on a Virtex-6 FPGA and a Spartan FPGAs within two AMCs (SIS8300-L2V2 and DAMC-FMC20). The compact single cavity control system was tested at Cryo Module Test Bench (CMTB) at DESY. Software and firmware were developed to support all possible modes, the short pulse (SP), the long pulse (LP) and CW operation mode with duty cycles ranging from 1 % to 100%. The SP mode used a high power multi-beam klystron at low QL ~3·10⁶. For the LP mode (up to 50% duty cycle) and the CW mode a 120 kW IOT tube was used at QL up to 1.5·10⁷. Within this paper we present the achieved performance and report on the operation experience on such system.
Kinetic theory of enzymatic reactions in reversed micellar systems (1990)

A kinetic theory is proposed for enzymatic reactions proceeding in reversed micellar systems in organic solvents, and involving substrates capable of partitioning among all pseudophases of the micellar system i.e. aqueous cores of reversed micelles, micellar membranes and organic solvent. The theory permits determination of true (i.e. with reference to the aqueous phase, where solubilized enzyme is localized) catalytic parameters of the enzyme, provided partition coefficients of the substrate between different phases are known. The validity of the kinetic theory was verified by the example of oxidation of aliphatic alcohols catalyzed by horse liver alcohol dehydrogenase in the system of reversed sodium bis(2-ethylhexyl)sulfosuccinate (AOT, aerosol OT) micelles in octane. In order to determine partition coefficients of alcohols between phases of the micellar system, flow microcalorimetry technique was used. It was shown that in the first approximation, the partition coefficient of the substrate in a simple biphasic system consisting of water and corresponding organic solvent can be used as an estimate for the partition coefficient of the substrate between aqueous and organic solvent phases of the micellar system. True values of the Michaelis constant of alcohols in the micellar system, determined using suggested approach, are equal to those obtained in aqueous solution and differ from apparent values referred to the total volume of the system. The results clearly show that the previously reported shift in the substrate specificity of HLADH, observed on changing from aqueous solution to the system of reversed aerosol OT micelles in octane, is apparent and can be explained on the basis of partitioning effects of alcoholic substrates between phases of the micellar system.
Metabolic Labeling of Proteins for Proteomics (2005)

Realization of the advantages of stable isotope labeling for proteomics has emerged gradually. However, many stable isotope label approaches rely on labeling in vitro using complex and sometimes expensive reagents. This review discusses strategies for labeling protein in vivo through metabolic incorporation of label into protein. This approach has many advantages, is particularly suited to single cells grown in culture (prokaryotic or eukaryotic), but is nonetheless subject to a number of complicating factors that must be controlled so that meaningful experiments can be conducted. Confounding issues include the metabolic lability of the amino acid precursor, incomplete labeling, and the role of protein turnover in labeling kinetics. All of these are controllable, provided that appropriate precautions are adopted.
Inferring electrospray emission characteristics from molecular dynamics and simulated retarding potential analysis (2023)

In this work, we present coordinated molecular dynamics, ion cluster acceleration, and retarding potential analysis simulations to determine cluster fragmentation behavior in a realistic emitter geometry for electrosprays operating in the pure ionic regime. Molecular dynamics simulations are used to determine the fragmentation rates of ionic liquid clusters as a function of internal energy, electric field strength, and cluster size. A simplified model of electrospray cluster acceleration is developed from previous electrohydrodynamic emission models and used to simulate retarding potential analysis curves. Fragmentation rates and beam composition are inferred for experimental data based on the molecular dynamics and cluster acceleration simulations. We find that for these experimental data, temperatures of EMI-BF4 dimers likely range between 590 and 687 K while trimer temperatures are larger between 989 and 1092 K. The percentage of monomers, dimers, and trimers in the beam is approximately 45%, 30%–43%, and 13%–25%, respectively. Both ionic liquid cluster temperatures and beam composition agree with previous analysis of this experimental work, supporting the use of coordinated molecular dynamics and retarding potential analysis as a method of inferring electrospray beam parameters. Insights gained from this simulation process are discussed in the context of currently unexplained electrospray emitter behavior and experimental results including the presence of tetramers and trimers in the beam and fragmentation rates in high electric field regions.
Measuring the population burden of chronic kidney disease: a systematic literature review of the estimated prevalence of impaired kidney function (2011)

In the general population, estimated iKF, particularly eGFR 30-59 mL/min/1.73m(2) was common with prevalence similar to diabetes mellitus. Appropriate care of patients poses a substantial global health care challenge.
Relaxin increases ubiquitin-dependent degradation of fibronectin in vitro and ameliorates renal fibrosis in vivo (2003)

Fibronectin, a large adhesive glycoprotein, is a prominent constituent of the extracellular matrix. Abnormalities in fibronectin homeostasis occur in numerous disease states, ranging from primary fibrosing conditions to neoplastic transformation. We demonstrate that fibronectin is a target protein substrate for ubiquitin-dependent degradation. Coimmunoprecipitation experiments and confocal microscopy demonstrated ubiquitin-fibronectin interaction. In an in vitro model of renal fibrosis, relaxin, an insulin-like growth factor, increased ubiquitin-dependent fibronectin degradation. Relaxin also was evaluated in an anti-glomerular basement membrane model of renal fibrosis. Animals treated with relaxin experienced renoprotection, manifested by decreased serum creatinine and proteinuria. Histological evaluation of kidney sections from animals treated with relaxin showed decreased glomerulosclerosis and interstitial fibrosis. We conclude that relaxin might be developed as a useful agent for the treatment of renal fibrosis.
Provably good global buffering by multiterminal multicommodity flow approximation (2002)

To implement high-performance global interconnect without impacting the placement and performance of existing blocks, the use of buffer blocks is becoming increasingly popular in structured-custom and block-based ASIC methodologies. Recent works by Cong, Kong and Pan (1999) and Tang and Wong (2000) give algorithms to solve the buffer block planning problem. In this paper, we address the problem of how to perform buffering of global multiterminal nets given an existing buffer block plan. We give a provably good algorithm based on a recent approach of Garg and Konemann (1998) and Fleischer (1999) [see also Albrecht (2000) and Dragan et al. (2000)]. Our method routes connections using available buffer blocks, such that required upper and lower bounds on buffer intervals-as well as wirelength upper bounds per connection-are satisfied. In addition, our algorithm allows more than one buffer to be inserted into any given connection and observes buffer parity constraints. Most importantly, and unlike previous works on the problem, we take into account multiterminal nets. Our algorithm outperforms existing algorithms for the problem, which are based on 2-pin decompositions of the nets. The algorithm has been validated on top-level layouts extracted from a recent high-end microprocessor design.
The IL-17F/IL-17RC Axis Promotes Respiratory Allergy in the Proximal Airways (2017)

The interleukin 17 (IL-17) cytokine and receptor family is central to antimicrobial resistance and inflammation in the lung. Mice lacking IL-17A, IL-17F, or the IL-17RA subunit were compared with wild-type mice for susceptibility to airway inflammation in models of infection and allergy. Signaling through IL-17RA was required for efficient microbial clearance and prevention of allergy; in the absence of IL-17RA, signaling through IL-17RC on epithelial cells, predominantly by IL-17F, significantly exacerbated lower airway Aspergillus or Pseudomonas infection and allergic airway inflammation. In contrast, following infection with the upper respiratory pathogen Staphylococcus aureus, the IL-17F/IL-17RC axis mediated protection. Thus, IL-17A and IL-17F exert distinct biological effects during pulmonary infection; the IL-17F/IL-17RC signaling axis has the potential to significantly worsen pathogen-associated inflammation of the lower respiratory tract in particular, and should be investigated further as a therapeutic target for treating pathological inflammation in the lung.
Negative differential conductance in lateral double-barrier transistors fabricated in strained Si quantum wells (1997)

The operation of a laterally patterned negative differential conductance (NDC) device based on hot-electron effects in strained Si quantum wells is demonstrated. The device consists of a small, etch-defined dot region connected to narrow leads on either side via point-contact tunnel barriers. The entire device is fabricated on a high-mobility Si/Si1−xGex heterostructure wafer using electron-beam lithography and low-damage reactive-ion etching. At T=0.4 K (T=1.3 K), the drain characteristic of this device shows a pronounced NDC region with a peak-to-valley ratio (PVR) greater than 600 (100). The PVR is reduced with increasing temperature, with remnants of the NDC observable to 30 K. The NDC is attributed to phonon emission by hot electrons injected into the dot region.
Per-oral extended-release bioadhesive tablet formulation of verapamil HCl. (2003)

The objective of this study was to formulate a hydrogel-forming bioadhesive drug delivery system for oral administration of verapamil HCl (VP). This system is a non-distintegrating gastro-retentive tablet to allow continuous slow release of VP in the stomach medium where it is more soluble. Different formulate of VP tablets were prepared by compression using various proportions of hydroxypropyl cellulose (HPC) and carbopol 934p (CP). The effect of polymer concentration on the release profile, water uptake and in vitro bioadhesion was studied. Five formulae (F3-F7) exhibited slow release profiles. Formulations F6 (40% HPC and 30% CP) and F7 (40% HPC and 40% CP) had the slowest. They showed 63.6 and 52.2% drug release, respectively, after 12 hours. The kinetic analysis of the release data demonstrated that the bigbest linearity were achieved when data fitted in Higuchi equation rather than zero or first order equations. They had n values close to 0.5 that confirming their Higuchi diffusion. F3 showed the highest swelling index (101.2%), however, the detachment force was intermediate (1.427 N/cm2). Formulae (F4-F7) showed relatively strong in-vitro bioadhesive force. They had detachment forces higher than 1 N/cm2. In general, a delay in drug release and an increase in the in-vitro bioadhesion was seen with the increase in both polymer concentrations. The in vitro data revealed that Formulae F4-F7 served the dual purpose of bioadhesion and sustained release.
Effect of Mn-Doping on the Piezoelectric Properties of (K0.5Na0.5)(Nb0.67Ta0.33)O3 Lead-Free Ceramics (2008)

The piezoelectric properties of 100(K0.5Na0.5)(Nb0.67Ta0.33)O3–x1/3Mn3O4 (abbreviated as KNNT–xMn) lead-free piezoelectric ceramics were investigated as a function of x. These ceramics were fabricated by conventional ceramics processing with K4.1CuTa7.7O22.3 (KCT) and ZnO as sintering aids. Mn-doping was found to decrease the phase transition temperature from tetragonal to orthorhombic (TO–T) near room temperature and clearly increase the d33 value. A high d33 value of 240 pC/N was obtained at x = 1.4. Values of kp and Qm kept were also maintained at over 0.40 and 280, respectively in the range of x = 0–2.0.
Metrics and Models in Software Quality Engineering (1994)

From the Publisher:
Author Biography: 
Dr. Stephen H. Kan, an ASQC Certified Quality Engineer, is responsible for IBM Rochester's software quality strategy and plans, quality assessment, software measurements, and statistical analysis. He has been the software quality focal point for the software system of the AS/400 computer since its initial release in 1988.
Ultrasonic relaxation studies of mixed micelles formed from alcohol-decyltrimethylammonium bromide-water (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUltrasonic relaxation studies of mixed micelles formed from alcohol-decyltrimethylammonium bromide-waterDavid J. Jobe, R. E. Verrall, Bohdan Skalski, and Emilio AicartCite this: J. Phys. Chem. 1992, 96, 16, 6811–6817Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/j100195a051https://doi.org/10.1021/j100195a051research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Characterisation and optimisation of Volume Holographic Optical Elements (VHOEs) in AR combiners for ghost reduction (2018)

Studies to integrate increased sensory capacities of the wearer on head mounted displays are growing fast for applications in augmented, virtual and mixed reality. This paper focuses on the characterisation of the combiner of the UNO augmented reality glasses by GlassUp: a volume holographic optical element, recorded at 532 nm on Bayfol&reg; HX, providing high diffraction efficiency over a narrow bandwidth at the desired angles. Furthermore, there is a negligible impact on the head mounted display frontal lens’s width and on the view of the real world. Studying the volume hologram, we developed a characterisation tool that gave us insight into the patterns inside the polymer and served as quality check for UNO. In particular, we designed a setup that provides Total Angular Characterisation through Optical Spectroscopy (TACOS), acquiring the visible spectral response of VHOEs as transmittance, reflectance or dispersion maps at arbitrary angles. Furthermore, it analyses the patterns through a custom fit based on the Kogelnik model. The early stages volumetric holograms presented undesirable secondary efficiency peaks causing ghosts, impairing both the vision of the real world and the image projected by the optical module. TACOS’ custom fit allowed us to conduct a quantitative analysis on the ghosts. In this work, we present an equilibrium study on all these parameters to find the better condition of projection. Moreover, we studied the impact of the recording parameters on the appearance of ghosts, e.g. tuning exposure, power ratios.
BOLETIN DE FILOSOFIA Y LETRAS (1979)

LA FACULTAD DE FILOSOFIA Y LETRAS (FFYL) PUBLICO SU BOLETIN BIMESTRAL, EN EL QUE SE PRESENTA INFORMACION SOBRE LAS PRINCIPALES ACTIVIDADES EDUCATIVAS Y CULTURALES QUE SE REALIZAN EN LA MENCIONADA DEPENDENCIA UNIVERSITARIA. DESTACA LA REPRODUCCION DE LAS PARTES SIGNIFICATIVAS DEL TERCER CICLO DE CONFERENCIAS ESCRITORES-PROFESORES, DEDICADO A MAESTROS FILOSOFOS. EN LA PUBLICACION SE SINTETIZAN LAS INTERVENCIONES DE LOS ESPECIALISTAS O SU DIALOGO CON LOS COMENTARISTAS. POR OTRA PARTE, TAMBIEN APARECE EL DOCUMENTO QUE REDACTO EL DOCTOR HUGO MARGAIN CHARLES, QUIEN FALLECIERA TRAGICAMENTE EL 29 DE AGOSTO DE 1978, COMO UNA GUIA PARA SU TOMA DE POSESION EN LA DIRECCION DEL INSTITUTO DE INVESTIGACIONES FILOSOFICAS (IIF). EL TEXTO REFLEJA LA VISION Y LOS PROYECTOS QUE EL DOCTOR MARGAIN TUVO EN RELACION AL INSTITUTO.
Pyrene and anthracene dicarboxylic acids as fluorescent brightening comonomers for polyester (2000)

Diacids of fused arenes have been prepared for use as covalently bound fluorescent optical brightening agents in condensation polymers. The monomers: dimethyl 1,6-pyrene dicarboxylate, dimethyl 1,8-pyrenedicarboxylate, dimethyl 2,7-pyrenedicarboxylate, 1,8-bis(2-carboxybenzoyl)pyrene dimethyl ester, dimethyl 2,6-anthracenedicarboxylate, dimethyl 2,7-anthracenedicarboxylate and dimethyl 9,10-anthracenedicarboxylate are copolymerized with poly(ethylene terephthalate) and their optical properties are assessed. All of the polymers give blue fluorescence, with the copolymer containing dimethyl 1,6-pyrenedicarboxylate being the brightest. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 1291–1301, 2000
Integrated optical fibre coupler (2017)

Integrated Optical Fibre (lOF) is a low-loss photonic platform that directly integrates optical fibre to a planar substrate. The platform possess advantages associated with optical fibre including low propagation loss, whilst at the same time enabling planar functionality associated with integrated optics. IOF fabrication is achieved through a modified Flame Hydrolysis Deposition (FHD) technique that forms a robust glass alloy between the fibre and substrate. The binding medium is of optical quality and mechanically robust, illustrated in fig 1 (a). Although non-trivial seamless on/off-chip coupling has also been demonstrated, which could further act to minimise coupling losses typically associated with integrated optics.
New drugs for the treatment of hypercholesterolaemia (2003)

Endogenous and exogenous pathways determine plasma levels of cholesterol and lipoproteins. Plasma cholesterol levels and coronary heart disease risk can be reduced pharmacologically by decreasing cholesterol synthesis, increasing its elimination and/or reducing its absorption from the intestine. The more profound knowledge about cholesterol homeostasis has allowed the development of several lipid-lowering drugs with different mechanisms of action, with the purpose of reducing both morbidity and mortality associated with coronary heart disease. Two new and more potent 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins), also called superstatins (rosuvastatin and pitavastatin), are being studied for their ability to improve lipid profiles. Rosuvastatin is a potent, hepato-selective and relatively hydrophilic statin with a low propensity for muscle toxicity and drug interactions. Pitavastatin is another statin with a high oral bioavailability and minimal propensity for cytochrome P450-mediated drug interactions. Rosuvastatin seems to be more potent than other available statins while pitavastatin presents with a similar potency to that of atorvastatin. Another promising approach for lowering total and low-density lipoprotein cholesterol levels is inhibition of cholesterol absorption. A wide variety of new agents with the capacity for inhibiting the intestinal cholesterol absorption is currently being investigated. Ezetimibe is a selective cholesterol absorption inhibitor whose clinical efficacy has been recently demonstrated both in monotherapy and in combination with other lipid-lowering drugs. Colesevelam, a new bile acid sequestrant, has shown a clinical efficacy similar to that of other resins, with minimal gastrointestinal side effects, improving tolerability and patient compliance. Other lipid-lowering drugs with the ability to act at the enterocyte level, such as avasimibe and implitapide, are currently being investigated in humans.
Combining CDK4/6 inhibitors ribociclib and palbociclib with cytotoxic agents does not enhance cytotoxicity (2019)

Cyclin-dependent kinases 4 and 6 (CDK4/6) play critical roles in the G1 to S checkpoint of the cell cycle and have been shown to be overactive in several human cancers. Small-molecule inhibitors of CDK4/6 have demonstrated significant efficacy against many solid tumors. Since CDK4/6 inhibition is thought to induce cell cycle arrest at the G1/S checkpoint, much interest has been focused on combining CDK4/6 inhibitors with cytotoxic agents active against the S or M phase of the cell cycle to enhance therapeutic efficacy. However, it remains unclear how best to combine these two classes of drugs to avoid their potentially antagonistic effects. Here, we test various combinations of highly selective and potent CDK4/6 inhibitors with commonly used cytotoxic drugs in several cancer cell lines derived from lung, breast and brain cancers, for their cell-killing effects as compared to monotherapy. All combinations, either concurrent or sequential, failed to enhance cell-killing effects. Importantly, in certain schedules, especially pre-treatment with a CDK4/6 inhibitor, combining these drugs resulted in reduced cytotoxicity of cytotoxic agents. These findings urge cautions when combining these two classes of agents in clinical settings.
Combined Raman Spectroscopy and SEM Analysis of CVD Grown Carbon Nanotubes (2008)

Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7, 2008