gebhart/patrepeval huggingface dataset:
Isolation and characterization of four ethylene signal transduction elements in plums (Prunus salicina L.) (2007)

Plums are climacteric fruits: their ripening is associated with a burst of ethylene production and respiration rate. Stone fruits, including plum, have a distinct pattern of growth and development, described as a double sigmoid pattern. In order to understand the developmental control of ethylene perception in plum, four ethylene perception and signal transduction components (EPSTCs) were characterized, including two ETR1-like proteins (Ps-ETR1 and Ps-ERS1), a CTR1-like protein, and an ethylene-responsive element-binding factor (ERF). Their regulation was studied throughout fruit development and ripening in early and late cultivars. Analysis of transcript levels revealed that only Ps-ERF1 and Ps-ERS1 accumulated immediately after fertilization. Increases in Ps-ETR1 and Ps-CTR1 transcript levels could not be detected before S3 of fruit development. Marked differences associated with the ripening behaviour of early ('Early Golden') and late ('Shiro') Japanese plum cultivars were observed. The early cultivar showed ripening patterns typical of climacteric fruits accompanied by sharp increases of the four transcript levels in an ethylene-dependent manner. However, the late cultivar exhibited a suppressed-climacteric pattern, with a slight increase in ethylene production related to ripening. The accumulation of the Ps-ETR1 (and not Ps-CTR1) mRNA in the late cultivar was ethylene independent. Ps-ERS1 mRNA was expressed at low, constant levels, while, Ps-ERF1 remained undetectable. The differences between the two plum cultivars in the date and rate of ripening in relation to the differences in the accumulation patterns of the four mRNAs are discussed.
Blind Coarse Timing Offset Estimation for CP-OFDM and ZP-OFDM Transmission over Frequency Selective Channels (2010)

We present a blind coarse timing offset estimation technique for CP-OFDM and ZP-OFDM transmission over frequency selective channels. The technique exploits the cyclic prefix or zero-padding structure to estimate the starting position of the OFDM symbols without requiring any additional pilots. Simulation results are performed on various channel models with timing and frequency offsets. The presented technique is compared with the autocorrelation-based technique and various techniques in frequency selective channels. Our algorithm shows better performance results than those of the autocorrelation-based technique in NLOS channels, where the most predominant channel path is usually not the first arrival path.
Modeling of the Renal Kinetics of the AT1 Receptor Specific PET Radioligand [11C]KR31173 (2013)

Correlations between various binding parameters support the concept of the parallel connectivity compartmental model. If an arterial input function cannot be obtained, simple radioligand retention may be adequate for estimation of in vivo radioligand binding.
Suppression of the magnetic phase transition in manganites close to the metal-insulator crossover (2004)

We report the suppression of the ferromagnetic phase transition in ${\mathrm{La}}_{1\ensuremath{-}x}{\mathrm{Ca}}_{x}\mathrm{Mn}{\mathrm{O}}_{3}$ close to the localized-to-itinerant electronic transition, i.e., at $x\ensuremath{\approx}0.2$ and $x\ensuremath{\approx}0.5$. A new crossover temperature ${T}_{f}$ can be defined for these compositions instead of ${T}_{\mathrm{C}}$. Unlike in common continuous magnetic phase transition the susceptibility does not diverge at ${T}_{f}$ and a spontaneous magnetization cannot be defined below it. We propose that the proximity to the doping-induced metal-insulator transition breaks up the electronic/magnetic homogeneity of the system and explains these effects.
Multinational Observational Cohort Study of COVID-19–Associated Pulmonary Aspergillosis1 (2021)

We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease-associated pulmonary aspergillosis (CAPA). We found 10%-15% CAPA incidence among 823 patients in 2 cohorts. Several factors were independently associated with CAPA in 1 cohort and mortality rates were 43%-52%.
Intermodulation Interference Detection in 6G Networks: A Machine Learning Approach (2021)

This paper demonstrates the use of machine learning to detect the presence of intermodulation interference across several wireless carriers. We show a salient characteristic of intermodulation interference and propose a machine learning based algorithm that detects the presence of intermodulation interference through the use of supervised learning. This algorithm can use the radio access network intelligent controller or the sixth generation of wireless communication (6G) edge node as a means of computation. Our proposed algorithm runs in linear time in the number of resource blocks, making it a suitable radio resource management application in 6G.
Structure-based design of thrombin inhibitors. (2003)

Despite tremendous efforts by the pharmaceutical industry during the last decade, the prevention of thromboembolic events--the major cause of death in industrialized countries--by efficient anticoagulatory therapy has still not been achieved. One therapeutic strategy focuses on competitive small-molecule thrombin inhibitors, which may block undesirable excessive thrombin activity (conversion of fibrinogen to fibrin and activation of platelet aggregation) and inactivate thrombin in preformed clots. The design of potent tailor-made thrombin inhibitors has been carried out based on structural data; however, the requirements for a target inhibitor, i.e., good pharmacokinetic and physicochemical profiles, still need to be addressed. This constitutes the main challenge in the current quest for a marketable drug, and is the major focus of the developments described in this review.
Python 3 types in the wild: a tale of two type systems (2020)

Python 3 is a highly dynamic language, but it has introduced a syntax for expressing types with PEP484. This paper explores how developers use these type annotations, the type system semantics provided by type checking and inference tools, and the performance of these tools. We evaluate the types and tools on a corpus of public GitHub repositories. We review MyPy and PyType, two canonical static type checking and inference tools, and their distinct approaches to type analysis. We then address three research questions: (i) How often and in what ways do developers use Python 3 types? (ii) Which type errors do developers make? (iii) How do type errors from different tools compare?
Abstract 624: Interactions Between Adenylate Cyclase Type 9 (ADCY9) and Cholesteryl Ester Transfer Protein (CETP) in Atherosclerosis (2018)

Pharmacogenomic studies have shown that ADCY9 genotype determines the effects of the cholesteryl ester transfer protein (CETP) inhibitor dalcetrapib on cardiovascular events, atherosclerosis imaging and body weight variation. The underlying mechanisms responsible for the interactions between ADCY9 and CETP have not yet been determined. Adcy9 -inactivated ( Adcy9 Gt/Gt ) and wild-type (WT) mice, that were or not transgenic for the CETP gene (CETP Gt and CETP WT ), were submitted to an atherogenic protocol (injection of an AAV8 expressing a PCSK9 gain-of-function variant and 0.75% cholesterol diet for 16 weeks). Atherosclerosis, cell adhesion, vasorelaxation, telemetry and adipose tissue MRI were evaluated. Adcy9 Gt/Gt mice had a 65% reduction in aortic atherosclerosis compared to WT ( P &lt;0.01). CD68-positive macrophage accumulation and proliferation in plaques were reduced in Adcy9 Gt/Gt mice compared to WT animals ( P &lt;0.05 for both). Adcy9 inactivation did not change counts of blood monocytes and their subsets. Splenocytes showed reduced adhesion to native aortic endothelium from Adcy9 Gt/Gt mice ( P &lt;0.05 vs WT). Femoral artery endothelial-dependent vasorelaxation was improved in Adcy9 Gt/Gt mice (versus WT, P &lt;0.01). Selective pharmacological blockade showed that the nitric oxide, cyclooxygenase and endothelial-dependent hyperpolarization pathways all contributed to the improvement of vasodilatation in Adcy9 Gt/Gt versus WT ( P &lt;0.01 for all). Adcy9 Gt/Gt mice gained more weight than WT with the atherogenic diet, and this was associated with an increase in whole body adipose tissue volume ( P &lt;0.05 for both). Feed efficiency was increased in Adcy9 Gt/Gt compared to WT mice ( P &lt;0.05), which was accompanied by improved nocturnal heart rate variability ( P =0.0572) and prolonged cardiac RR interval ( P &lt;0.05). Adcy9 inactivation-induced effects on atherosclerosis, endothelium-dependent vasodilation, weight gain and feed efficiency were lost in CETP Gt mice ( P &gt;0.05 vs CETP WT ). Adcy9 inactivation protects against atherosclerosis, but only in the absence of CETP activity. This atheroprotection may be explained by decreased macrophage accumulation and proliferation in the arterial wall, improved endothelial function and autonomic tone.
A generative adversarial inpainting network to enhance prediction of periodontal clinical attachment level (2022)

Artificial intelligence was developed and utilized to predict clinical attachment level compared to clinical measurements. A generative adversarial inpainting network with partial convolutions was developed, tested and validated to predict clinical attachment level. The inpainting approach was found to be superior to non-inpainted methods and within the 1mm clinician-determined measurement standard.
Gastrointestinal Hormones Manipulation to Counteract Metabolic Syndrome Using Duodenal Targeted Embolization (2019)

GDA embolization induced a decrease in ghrelin production and influenced expression of glucose carriers in the foregut mucosa.
Korean Semantic Role Labeling with BERT (2020)

의미역 결정은 문장 내에서 “누가, 무엇을, 어떻게, 왜” 등의 관계를 찾아내는 자연어처리의 한 응용이다. 최근 의미역 결정 연구는 주로 기계학습을 이용하고 자질 정보를 배제한 종단 대 종단(end-to-end) 방식의 연구가 이루어지고 있다. 최근 BERT(Bidirectional Encoder Representations from Transformers)라는 언어 모델이 자연어처리 분야에 등장하여 기존 자연어처리 분야의 최고 성능 모델들 보다 더 좋은 성능을 보이고 있다. 종단 대 종단 방식을 이용한 의미역 결정 연구의 성능은 주로 기계학습 모델의 구조나 사전에 학습된 언어 모델의 영향을 받는다. 따라서 본 논문에서는 한국어 의미역 결정성능 향상을 위해 BERT를 한국어 의미역 결정에 적용한다. 실험 결과 BERT를 이용한 한국어 의미역 결정 모델의 성능이 85.77%로 기존 한국어 의미역 결정 모델들 보다 좋은 성능을 보였다.
Time Optimum Control of Second-Order Overdamped Systems with Transportation Lag (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTime Optimum Control of Second-Order Overdamped Systems with Transportation LagL. B. Koppel and P. R. LatourCite this: Ind. Eng. Chem. Fundamen. 1965, 4, 4, 463–471Publication Date (Print):November 1, 1965Publication History Published online1 May 2002Published inissue 1 November 1965https://pubs.acs.org/doi/10.1021/i160016a019https://doi.org/10.1021/i160016a019research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Experimental evidence of end effects in magneto-electric laminate composites (2007)

This paper experimentally and theoretically studies the magneto-electric (M-E) responses of layered magnetostrictive and piezoelectric composites. A total of three different piezoelectric volume fractions of 0.17, 0.29, and 0.44 were prepared to investigate the strain variation in the sample and the effective M-E voltage coefficient α¯ as a function of bias magnetic field Hbias. Analytical modeling involving uniform strain, shear lag only, and shear lag plus demagnetization was performed and compared with experimental measurements. The results demonstrate that the uniform strain theory significantly overestimates the measured strain and α¯ values. This discrepancy is physically attributed to shear lag and demagnetizing effects. The analytical models involving shear lag and demagnetizing effects agree with the experimental results well within 5%.
Induction of CD4+CD25+FOXP3+ Regulatory T Cells during Human Hookworm Infection Modulates Antigen-Mediated Lymphocyte Proliferation (2011)

Hookworm infection is considered one of the most important poverty-promoting neglected tropical diseases, infecting 576 to 740 million people worldwide, especially in the tropics and subtropics. These blood-feeding nematodes have a remarkable ability to downmodulate the host immune response, protecting themselves from elimination and minimizing severe host pathology. While several mechanisms may be involved in the immunomodulation by parasitic infection, experimental evidences have pointed toward the possible involvement of regulatory T cells (Tregs) in downregulating effector T-cell responses upon chronic infection. However, the role of Tregs cells in human hookworm infection is still poorly understood and has not been addressed yet. In the current study we observed an augmentation of circulating CD4(+)CD25(+)FOXP3(+) regulatory T cells in hookworm-infected individuals compared with healthy non-infected donors. We have also demonstrated that infected individuals present higher levels of circulating Treg cells expressing CTLA-4, GITR, IL-10, TGF-β and IL-17. Moreover, we showed that hookworm crude antigen stimulation reduces the number of CD4(+)CD25(+)FOXP3(+) T regulatory cells co-expressing IL-17 in infected individuals. Finally, PBMCs from infected individuals pulsed with excreted/secreted products or hookworm crude antigens presented an impaired cellular proliferation, which was partially augmented by the depletion of Treg cells. Our results suggest that Treg cells may play an important role in hookworm-induced immunosuppression, contributing to the longevity of hookworm survival in infected people.
Analysis of the psychometric properties of two different concept-map assessment tasks (2008)

This Dissertation is brought to you for free and open access by BYU ScholarsArchive. It has been accepted for inclusion in All Theses and Dissertations by an authorized administrator of BYU ScholarsArchive. For more information, please contact scholarsarchive@byu.edu.
Dynamics of early post-operative plasma ddcfDNA levels in kidney transplantation: a single-center pilot study (2018)

Donor-derived cell-free DNA (ddcfDNA) is reported to be a promising noninvasive biomarker for acute rejection in organ transplant. However, studies on monitoring ddcfDNA dynamics during the early periods after organ transplantation are scarce. Our study assessed the dynamic variation in ddcfDNA in early period with various types and status of kidney transplantation. Target region capture sequencing used identifies ddcfDNA level in 21 kidney transplant recipients. Median ddcfDNA level was 20.69% at the initial time post-transplant, and decreased to 5.22% on the first day and stayed at the stable level after the second day. The ddcfDNA level in DCD (deceased donors) group (44.99%) was significantly higher than that in LDRT (living donor) group (10.24%) at initial time, P < 0.01. DdcfDNA level in DGF (delayed graft function) recipients was lower (23.96%) than that in non-DGF (47.74%) at the initial time, P = 0.89 (19.34% in DGF and 4.46% in non-DGF on the first day, P = 0.17). DdcfDNA level at initial time significantly correlated with serum creatinine (r<sup>2</sup> = 0.219, P = 0.032) and warm ischemia time (r<sup>2</sup> = 0.204, P = 0.040). Plasma ddcfDNA level decreased rapidly follow an L-shaped curve post-transplant, and level in DGF declined slower than non-DGF. The rebound of ddcfDNA level may indicate the occurrence of acute rejection.
Computer Simulation of Earthquake Effects (2000)

Proceedings of sessions of Geo-Denver 2000, held in Denver, Colorado, August 5-8, 2000. Sponsored by the Geo-Institute of ASCE. This Geotechnical Special Publication contains 9 papers presenting new techniques for predicting the liquefaction behavior of saturated sands during earthquakes. New techniques meriting serious consideration include shear wave velocity techniques, electrical methods, and ground penetrating radar, all of which have potential for providing new, reliable information. This volume also examines nondestructive site characterization and property evaluation, constitutive modeling and numerical procedures, and applications. Topics include: details on the use of an electrical technique for evaluating in situ properties; the use of ground penetrating radar for predicting changes in soil density during soil liquefaction; how shear wave velocities measured in situ are capable of predicting the liquefaction potential; the constitutive modeling of flow liquefaction and cyclic mobility in detail; soil-pile structure interaction in liquefiable soils; and nondestructive electrical in situ site characterization to quantify the initial state parameters and constitutive model constants representative of the site for use in verified numerical procedures.
Inference about the Ratio of Two Parameters, with Application to Whale Censusing (1993)

Abstract Inference for the quotient of two parameters estimated separately may be obtained by the delta method. When the distribution of linear transformations involving the numerator and the denominator is available, more exact and elementary methods may be used. Non-Bayesian and Bayesian approaches are developed. The application of the methods to estimating the stock abundance of Northeastern Atlantic minke whales, where the ratio is a raw estimate divided by a measure of observation efficiency, is explained and discussed. The Bayesian approach allows exact inference in quite general situations using only a single, rapidly implemented, one-dimensional numerical integration. A simple analytic approximation is given for the common situation where the joint posterior distribution of the numerator and denominator can be approximated by a normal distribution that gives very little probability to negative values of the denominator. The Bayesian approach also permits the incorporation of model uncertainty (or disagreement) in a natural way, and this was the basis for the conclusions of the International Whaling Commission Scientific Committee at its 1990 meeting.
Fuzzy Logic-Based System for Identifying the Severity of Diabetic Macular Edema from OCT B-Scan Images Using DRIL, HRF, and Cystoids (2023)

Diabetic Macular Edema (DME) is a severe ocular complication commonly found in patients with diabetes. The condition can precipitate a significant drop in VA and, in extreme cases, may result in irreversible vision loss. Optical Coherence Tomography (OCT), a technique that yields high-resolution retinal images, is often employed by clinicians to assess the extent of DME in patients. However, the manual interpretation of OCT B-scan images for DME identification and severity grading can be error-prone, with false negatives potentially resulting in serious repercussions. In this paper, we investigate an Artificial Intelligence (AI) driven system that offers an end-to-end automated model, designed to accurately determine DME severity using OCT B-Scan images. This model operates by extracting specific biomarkers such as Disorganization of Retinal Inner Layers (DRIL), Hyper Reflective Foci (HRF), and cystoids from the OCT image, which are then utilized to ascertain DME severity. The rules guiding the fuzzy logic engine are derived from contemporary research in the field of DME and its association with various biomarkers evident in the OCT image. The proposed model demonstrates high efficacy, identifying images with DRIL with 93.3% accuracy and successfully segmenting HRF and cystoids from OCT images with dice similarity coefficients of 91.30% and 95.07% respectively. This study presents a comprehensive system capable of accurately grading DME severity using OCT B-scan images, serving as a potentially invaluable tool in the clinical assessment and treatment of DME.
FAILURE OF AN INDUCED OVULATION DURING LACTATION TO IMPROVE SOW OR LITTER PERFORMANCE (1990)

To test the effects of elevated blood progesterone on sow and litter performance, sixty-four, mixed parity Yorkshire × Landrace sows were allocated to be induced to ovulate during lactation (n = 34) or to serve as controls (n = 30). Ovulation was induced by an intramuscular injection of 1000 IU PMSG at 10 d and 500 IU hCG at 13 d of lactation. During lactation, sows were fed ad libitum a diet formulated to provide 13.1 MJ DE kg −1 and 16% crude protein while their feed intakes were recorded weekly. Piglets were weaned at 28–31 d of age. Of the 34 sows administered gonadotrophins, 19(56%) ovulated as indicated by elevated serum progesterone concentrations measured on days 20 and 28 of lactation. There was no effect (P &gt; 0.1) of ovulation during lactation on sow feed intake, weight loss or backfat loss (5.5 vs. 5.4 kg d −1 ; 20.3 vs. 15.4 kg and 2.3 vs. 1.7 mm for ovulating and control sows, respectively). Similarly, there was no effect (P &gt; 0.1) of ovulation during lactation on piglet weight gain from 14 to 28 d of age (3.1 vs. 3.1 kg) or on piglet preweaning survival (91.0 vs. 94.5% for ovulating and control litters, respectively). Sows ovulating during lactation had longer weaning to estrus intervals (9.4 vs. 5.4 d; P &lt; 0.01). It may be concluded that ovulation and an elevated serum progesterone concentration in the latter half of lactation will not influence sow or litter performance but may increase the interval between weaning and estrus. Key words: Sows, ovulation, lactation, appetite, reproduction
Size effects and giant magnetoresistance in unannealed NiFe/Ag multilayer stripes (1996)

We have observed giant magnetoresistance (GMR) in unannealed NiFe/Ag multilayer thin-film stripes. Rectangular stripes having constant thickness and a constant 11:1 length-to-width aspect ratio, but varying widths down to 0.5 μm, were measured. Two types of multilayer configurations were tested, a system of five NiFe/Ag bilayers with 5.5-nm-thick Ag spacer layers, and a system of nine bilayers with 4.4-nm-thick Ag layers. In contrast to the characteristic of annealed NiFe/Ag multilayer stripes, the unnannealed stripes produced increasing GMR ratios for decreasing stripe sizes, with the 0.5-μm-wide stripe of the five-bilayer system exhibiting a ΔR/R of 2.5%. Barkhausen noise and response broadening also increased with decreasing stripe size, however. The results are discussed in terms of magnetostatic coupling of the NiFe layers within the stripes.