gebhart/patrepeval huggingface dataset:
A DNA hairpin as a target for antisense oligonucleotides (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA DNA hairpin as a target for antisense oligonucleotidesElena Brossalina and Jean Jacques ToulmeCite this: J. Am. Chem. Soc. 1993, 115, 2, 796–797Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/ja00055a065https://doi.org/10.1021/ja00055a065research-articleACS PublicationsRequest reuse permissionsArticle Views94Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Visualization of Flow and Combustion Processes in a Square Piston Engine Simulator (1987)

&lt;div class="htmlview paragraph"&gt;A square-piston engine simulator used at Berkeley to study both spark-ignited and diesel engine processes is described. The square piston configuration provides optical access to fluid mechanical and combustion processes through two fiat quartz windows used as cylinder walls. Results from three previous research projects are reviewed to illustrate the engine's capabilities. Since these studies, we developed and used a color schlieren cinematography system to record in-cylinder processes. Color schlieren movies of both spark-ignition and diesel combustion reveal the essential fluid mechanical and combustion features within the engine. For these movies, we redesigned the diesel fuel system and installed a new liquid fuel injection system for spark-ignited operation. By preventing fuel and soot condensation on the windows, these new fuel systems improved the quality of our Schlieren images.&lt;/div&gt;
Artifact for "PHYSFRAME: Type Checking Physical Frames of Reference for Robotic Systems" (2021)

<strong>Summary</strong> <br> PHYSFRAME is a static analysis tool for detecting reference frame inconsistencies and violations of common practices (i.e., implicit frame conventions) in C/C++ projects that build against the [Robot Operating System](http://www.ros.org/). It requires nothing from the developers except running the tool on their project. The tool automatically models the project, and checks for problems. <br> <strong>Contents</strong> This repository contains the following files and folders: * README.md : This file.<br> * LICENSE.txt : BSD 2-Clause license.<br> * STATUS.txt : Describes the ACM artifact badges sought for this artifact.<br> * REQUIREMENTS.md : Describes the hardware and software requirements.<br> * INSTALL.txt : Describes how to install PHYSFRAME using Docker and a minimal working example.<br> * HOWTO.txt: Describes how to use PHYSFRAME with the provided data.<br> * HOWTO-WITH-SCRIPT.txt : Describes how to run scripts to evaluate PHYSFRAME with the provided data.<br> * untar_data.sh : Script to untar files in data/.<br> * evaluate_data.sh : Script to run PHYSFRAME on the provided data.<br> * evaluate_z-score.sh : Script to run PHYSFRAME on the provided data with z-score = 2, 5 or 10.<br> * Dockerfile : a Docker install file for PHYSFRAME.<br> * requirements.txt : List of python dependencies required by PHYSFRAME. Referenced by the Dockerfile.<br> * src/ : The python source code for PHYSFRAME, files containing implicit frame conventions.<br> * data/ : Dataset of C/C++ projects (downloaded from public GitHub repositories) used to evaluate PHYSFRAME.<br> * USER-GUIDE.txt : Helpful notes for user.
Spectral Irradiance (2016)

This glossary of terms covers phenomena considered under the very wide terms photocatalysis and radiation catalysis. A clear distinction is made between phenomena related to either photochemistry and photocatalysis or radiation chemistry and radiation catalysis. The term “radiation” is used here as embracing electromagnetic radiation of all wavelengths, but in general excluding fast-moving particles. Consistent definitions are given of terms in the areas mentioned above, as well as definitions of the most important parameters used for the quantitative description of the phenomena. Terms related to the up-scaling of photocatalytic processes for industrial applications have been included. This Glossary should be used together with the Glossary of terms used in photochemistry, 3rd edition, IUPAC Recommendations 2006: (doi:10.1351/pac200779030293) as well as with the IUPAC Compendium of Chemical Terminology, 2nd ed. (the “Gold Book” 2006–; doi:10.1351/goldbook), because many terms used in photocatalysis are defined in these documents.
Automated photogrammetry for three-dimensional models of urban spaces (2012)

The location-aware Internet is inspiring intensive work addressing the automated assembly of three-dimensional models of urban spaces with their buildings, circulation spaces, vegetation, signs, even their above-ground and underground utility lines. Two-dimensional geographic information systems (GISs) and municipal utility information exist and can serve to guide the creation of models being built with aerial, sometimes satellite imagery, streetside images, indoor imaging, and alternatively with light detection and ranging systems (LiDARs) carried on airplanes, cars, or mounted on tripods. We review the results of current research to automate the information extraction from sensor data. We show that aerial photography at ground sampling distances (GSD) of 1 to 10 cm is well suited to provide geometry data about building facades and roofs, that streetside imagery at 0.5 to 2 cm is particularly interesting when it is collected within community photo collections (CPCs) by the general public, and that the transition to digital imaging has opened the no-cost option of highly overlapping images in support of a more complete and thus more economical automation. LiDAR-systems are a widely used source of three-dimensional data, but they deliver information not really superior to digital photography.
[Effect of chondroitinase ABC on axonal myelination and glial scar after spinal cord injury in rats]. (2013)

The ChABC can effectively improve the microenvironment of the injured spinal cord of rats, enhance the expressions of MBP and GAP-43, and inhibit the expression of GFAP, which promotes the axonal regeneration and myelination, attenuate glial scar formation, and promote the recovery of nerve function.
Ultra-wide to narrow band agile reconfigurable frequency microstrip slot antenna (2012)

A simulation of reconfigurable frequency antenna is presented. The antenna is an integration of ultra-wide band antenna with a microstrip slot antenna. It has a capability to operate in ultra-wide band (0.98–12.0 GHz) and seven different narrow bands from 2 GHz to 4 GHz. Seventeen switches with eight configuration are used to select between ultra-wide band and the narrow bands. The proposed antenna demonstrates frequency agility which useful for future communication systems such as cognitive radios.
Soft Pneumatic Actuator skin with embedded sensors (2014)

Soft Pneumatic Actuator skin (SPA-skin) is a novel concept of ultra-thin (<; 1 mm) sensor embedded actuators with distributed actuation points that could cover soft bodies. This highly customizable and flexible SPA-skin is ideal for providing proprioceptive sensing by covering pre-existing structures and robots bodies. Having few limitation of the surface quality, dynamics, or shape, these mechanical attributes allow potential applications in autonomous flexible braille, active surface pattern reconfiguration, distributed actuation and sensing for tactile interface improvements. In this paper, the authors present a proof-of-concept SPA-skin. The mechanical parameters, design criteria, sensor selection, and actuator construction process are illustrated. Two control schemes, actuation mode and force sensing mode, are also demonstrated with the latest prototype.
Thermodynamics of Lipid Organization and Domain Formation in Phospholipid Bilayers (2000)

Lipid organization and domain formation in phospholipid membranes has a large impact on a number of physical membrane properties such as membrane elasticity, lipid lateral diffusion, permeability, and binding properties for peptides and proteins. The mixing behavior of lipids can be deduced from the binary phase diagram, i.e. temperature versus mole fraction diagram, describing the temperature induced phase transition behavior of lipid mixtures. An easy way to obtain experimental data to construct a binary phase diagram is differential scanning calorimetry (DSC) of aqueous dispersions of liposomes of lipid mixtures. The temperatures that correspond to points on the liquidus and solidus curves of the phase diagram are determined from the DSC thermograms, e.g. the experimental heat capacity curves. The main problem to solve is the correct determination of the onset and end of the melting curve for every single transition curve in a standardized manner, because of the lack of theoretically justified methods. To avoid this subjective procedure, we have developed a method for the simulation of heat capacity curves that are obtained by DSC. Our model uses a thermodynamic approach for the description of the miscibility of phospholipids, which is based on regular solution theory with an incorporation of a broadening function, taking into account the reduced cooperativity in mixed lipid bilayer systems. The output parameters of these simulations are nonideality parameters describing nonideal mixing in the gel and liquid crystalline phase, the temperature set describing the onset and end of melting, respectively, and a value for the cooperative unit size. These temperature data are then used for the construction and simulation of the phase diagrams. A four parameter model was used, taking into account the asymmetry of the mixing behavior, yielding two nonideality parameters for each phase. These nonideality parameters describe the interaction of both components in the single phase regions. We have employed this procedure to describe the mixing behavior of various binary phospholipid systems. We will show how the mixing behavior is influenced by changing the hydrocarbon chain length of one of the component, by changing the lipid-lipid head group interaction, or the pH and ionic strength of the dispersion. Examples of binary lipid mixtures in which domain formation in the liquid crystalline phase is observed, are presented.
Measurement of intraepithelial lymphocytes. (1986)

Penile ulceration in Crohn's disease SIR,-We read with interest the well documented cases of penile ulceration by Slaney et al (Gut 1986; 27: 329). We wish to describe a case of pyoderma gangrenosum affecting the penis in a patient with Crohn's disease, which had certain similarities. A 46 year old man presented with a few months history of bloody diarrhoea. A barium enema showed characteristic features of Crohn's disease affecting the transverse and descending colon with skip lesions. A small bowel enema was normal. He was treated with prednisolone and sulphasalazine and made a good recovery. Six months later he developed a discharging punched out ulcer on the skin in the interscapular area. The ulcer had typical features of a pyoderma gangrenosum which was confirmed by histology and responded to a local injection of Triamcinolone. At the same time he developed a rapidly enlarging tender nodular lesion on the dorsum of his penis which was excised. Histology showed granulation tissue and the excision resulted in a large ulcer similar to that shown in Fig. There was no serological or cytological evidence for a sexually transmitted di- sease. As the ulcer was discharging seropurulent material, was tender and unresponsive to local antibiotics and topical steroids, a six weeks course of oral prednisolone was given. This resulted in a complete healing of the ulcer. Two months later, however, he developed another nodular lesion at the junction of the glans and the shaft of the penis which was also excised. Histology showed typical features of pyoderma gangrenosum. The excision resulted in an ulcer which once again was refractory to topical treatment. In addition, he developed an indurated area 1 cm distal to the ulcer. These lesions failed to heal over the next four months in spite of treatment with oral prednisolone, supplemented later with azathioprine, but healed completely within six weeks of the injection of 2 mg Triamcinolone between the two lesions. During this period, his colitis was in remission. Eighteen months later he remains well and has had no further recurrence of his penile lesions.
MAGIC: a multiattribute declustering mechanism for multiprocessor database machines (1994)

During the past decade, parallel database systems have gained increased popularity due to their high performance, scalability, and availability characteristics. With the predicted future database sizes and complexity of queries, the scalability of these systems to hundreds and thousands of processors is essential for satisfying the projected demand. Several studies have repeatedly demonstrated that both the performance and scalability of a parallel database system are contingent on the physical layout of the data across the processors of the system. If the data are not declustered appropriately, the execution of an operation might waste system resources, reducing the overall processing capability of the system. With earlier, single-attribute partitioning mechanisms such as those found in the Tandem, Teradata, Gamma, and Bubba parallel database systems, range selections on any attribute other than the partitioning attribute must be sent to all processors containing tuples of the relation, while range selections on the partitioning attribute can be directed to only a subset of the processors. Although using all the processors for an operation is reasonable for resource intensive operations, directing a query with minimal resource requirements to processors that contain no relevant tuples wastes CPU cycles, communication bandwidth, and I/O bandwidth. As a solution, this paper describes a new partitioning strategy, multiattribute grid declustering (MAGIC), which can use two or more attributes of a relation to decluster its tuples across multiple processors and disks. In addition, MAGIC declustering, unlike other multiattribute partitioning mechanisms that have been proposed, is able to support range selections as well as exact match selections on each of the partitioning attributes. This capability enables a greater variety of selection operations to be directed to a restricted subset of the processors in the system. Finally, MAGIC partitions each relation based on the resource requirements of the queries that constitute the workload for the relation and the processing capacity of the system in order to ensure that the proper number of processors are used to execute queries that reference the relation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Integrated microfluidic platform for bilayer studies and experimentation on single pore-forming species (2011)

The combination of microfluidics with BLMs (bilayer lipid membranes) consists of a powerful tool for multiplexed and high-throughput studies on membrane properties and membrane proteins. Here, we report an integrated device for BLM ex-perimentation using both optical and electrical measurements. This platform is validated for fundamental studies on mem-brane properties, measurements using (single) pore-forming species and high-resolution (confocal) microscopy.
ChemInform Abstract: Highly Stereocontrolled Addition of Methyltitanium Reagent to α‐ Phenylthioaldehyde. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Safety evaluation of the food enzyme lysophospholipase from the genetically modified Aspergillus niger strain NZYM‐LP (2020)

The food enzyme is a lysophospholipase (2-lysophosphatidylcholine acylhydrolase; EC 3.1.1.5) produced with a genetically modified <i>Aspergillus niger</i> strain NZYM-LP by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA. The lysophospholipase food enzyme is intended to be used in starch processing for glucose syrups production, and for degumming of fats and oils. Residual amounts of total organic solids (TOS) are removed by the purification steps applied during the production of glucose syrups, and washing and purification steps applied during degumming, consequently, dietary exposure estimation was considered not necessary. Genotoxicity tests did not raise safety concerns. The repeated dose 90-day oral toxicity study was carried out with a phospholipase A1 from <i>A. niger</i> (strain NZYM-FP). The Panel considered this enzyme as a suitable substitute to be used in this toxicity study in rats, because they derive from the same recipient strain, the location of the inserts are comparable, no partial inserts were present and the production methods are essentially the same. The Panel identified a no observed adverse effect level (NOAEL) at the highest dose tested of 1,356 mg TOS/kg body weight (bw) per day. Similarity of the amino acid sequence to those of known allergens was searched and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood for this occurring is considered to be low. Based on the data provided, the removal of TOS during the starch processing for the production of glucose syrups and during the degumming of fats and oils, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
Release and characterization of single side chains of white cabbage pectin and their complement‐fixing activity (2009)

A mixture of single side chains from white cabbage pectin were obtained by anion exchange chromatography after applying mild chemical conditions promoting beta-elimination. These pectin fragments were characterized by their molecular weight distribution, sugar composition, 13C-NMR, and MALDI-TOF-MS analysis. These analyses revealed that the large oligosaccharides released by beta-eliminative treatment were composed of alpha-1,5 linked arabinosyl residues with 2- and 3-linked alpha-arabinosyl side chains, and, or beta-1,4 linked galactosyl side chains. Fractions were tested for complement-fixing activity in order to determine their interaction with the complement system. These results strongly indicated that there was a minimal unit size responsible for the complement-fixing activity. Neutral pectin fragments (8 kDa) obtained from beta-elimination were inactive in the complement system, although they contained a sugar composition previously shown to be highly active. Larger pectin fragments (17 kDa) retained some activity, but much lower than polymers containing rhamnogalacturonan type 1 (RGI) structures isolated from the same source. This implied that structural elements containing multiple side chains is necessary for efficient complement-fixing activity.
Measurement of Actinic Erythema in Healthy Subjects and in Subjects with Polymorphous Light Eruption Using a Tristimulus Colorimeter (1995)

Chromometric measurements of L* help to differentiate skin colour, whereas those of a* enable the discrimination of healthy subjects from those with photodermatosis.
Radioligand binding analysis of α2 adrenoceptors with [11C]yohimbine in brain in vivo: Extended Inhibition Plot correction for plasma protein binding (2017)

We describe a novel method of kinetic analysis of radioligand binding to neuroreceptors in brain in vivo, here applied to noradrenaline receptors in rat brain. The method uses positron emission tomography (PET) of [<sup>11</sup>C]yohimbine binding in brain to quantify the density and affinity of α <sub>2</sub> adrenoceptors under condition of changing radioligand binding to plasma proteins. We obtained dynamic PET recordings from brain of Spraque Dawley rats at baseline, followed by pharmacological challenge with unlabeled yohimbine (0.3 mg/kg). The challenge with unlabeled ligand failed to diminish radioligand accumulation in brain tissue, due to the blocking of radioligand binding to plasma proteins that elevated the free fractions of the radioligand in plasma. We devised a method that graphically resolved the masking of unlabeled ligand binding by the increase of radioligand free fractions in plasma. The Extended Inhibition Plot introduced here yielded an estimate of the volume of distribution of non-displaceable ligand in brain tissue that increased with the increase of the free fraction of the radioligand in plasma. The resulting binding potentials of the radioligand declined by 50-60% in the presence of unlabeled ligand. The kinetic unmasking of inhibited binding reflected in the increase of the reference volume of distribution yielded estimates of receptor saturation consistent with the binding of unlabeled ligand.
A Development of Automatically Control of Hazard Lamps of Automobiles (2006)

Nowadays, with the increasing number of automobiles, there are more and more traffic accidents. Even though with many safety devices installed, careless and inexperienced drivers often fail to take uses of advanced technologies built in the devices. One type of unfortunate and avoidable traffic accidents is when drivers in an emergency situation either forget or have no time to turn on the hazard lamps which play an important role in noticing other drivers to pay their attentions, in the result, a great number of follow-up-accidents happened. We have developed a system that is capable to keep trucking the condition of the automobile, and turn on the hazard lamps automatically when an emergency has occurred. The system is reliable, cheap, and no design changes required for the automobile.
[Antidepressants with different action mechanisms in the treatment of chronic daily headache]. (2007)

Efficacy and safety of the following antidepressants: amitryptiline (tricyclic antidepressant), escitalopram (selective inhibitor of serotonin reuptake), milnacipran (selective inhibitor of serotonin and noradrenalin reuptake) and maprotiline (selective inhibitor of noradrenalin reuptake) have been compared during the treatment of 120 patients with chronic daily headache. A positive effect was found for all drugs, in particular in the presence of depressive and anxiety symptoms. Most effective proved to be milnacipran and amitryptiline. Escitalopram and milnacipran were more tolerable and had less side-effects. The authors suggested that the combination of noradrenergic and serotoninergic components appears to be most effective in treatment of chronic daily headache.