gebhart/patrepeval huggingface dataset:
The photoexcited states of organic anions (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe photoexcited states of organic anionsMarye Anne FoxCite this: Chem. Rev. 1979, 79, 3, 253–273Publication Date (Print):June 1, 1979Publication History Published online1 May 2002Published inissue 1 June 1979https://pubs.acs.org/doi/10.1021/cr60319a002https://doi.org/10.1021/cr60319a002research-articleACS PublicationsRequest reuse permissionsArticle Views921Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Polyamines in the hydrogen-oxidizing eubacteria Hydrogenobacter, Calderobacterium and Hydrogenovibrio and the sulphur-reducing archaebacteria Stygiolobus and Desulfurolobus (1995)

A novel quaternary branched penta-amine, N 4 -bis(aminopropyl)norspermidine, was the main polyamine of the thermophilic, chemolithotrophic, hydrogen-oxidizing eubacteria, Hydrogenobacter acidophilus and Calderobacterium hydrogenophilum. The mesophilic, chemolithotrophic, hydrogen-oxidizing eubacterium, Hydrogenovibrio marinus contained putrescine and spermidine. The thermoacidophilic Stygiolobus azoricus growing chemolithotrophically by reduction of sulphur, and a thermoacidophile, Desulfurolobus ambivalens, growing chemolithotrophically by either oxidation or reduction of sulphur, belonging to the family Sulfolobaceae (order Sulfolobales) of the archaebacteria, ubiquitously contained norspermidine, spermidine, norspermine and spermine
Occupant- and crash-related factors associated with the risk of whiplash injury (2003)

PURPOSE: Given that a motor vehicle crash (MVC) had occurred, to evaluate whether occupant- and crash-related factors, such as age, gender, seating position and type of MVC are associated with the risk of whiplash injury. METHODS: A study of occupants in cars covered by motor insurance at one of the largest insurance companies in Sweden, was undertaken during a one-year period. The study population comprised all occupants in cars exposed to an MVC in which at least one occupant was injured (n = 7120). Adjusted estimates of the relative risk of whiplash injury, associated with the different factors, were calculated by means of binomial regression analysis. RESULTS: Considering different MVCs, rear-end collisions were associated with the highest relative risk of whiplash injury when compared with side impacts (1.82; 95% CI 1.68-1.96), while drivers showed the strongest association with respect to seating position when compared with passengers in the rear seat (1.78; 95% CI 1.60-1.97). Females had a somewhat higher relative risk of whiplash injury than males (1.20; 95% CI 1.16-1.25). Regarding age, the relative risk was moderately increased across the different age groups when compared with the oldest age group. No interaction was observed on the additive scale. CONCLUSIONS: Given that an MVC had occurred, subjects exposed to a rear-end collision and drivers had a substantial increased risk of whiplash injury, while age and gender were of minor importance. Language: en
Photoactivation of Amino-Substituted 1,4-Benzoquinones for Release of Carboxylate and Phenolate Leaving Groups Using Visible Light (2006)

Upon exposure to visible light, 2-pyrrolidino-substituted 3,6-dimethyl-1,4-benzoquinones photocyclize to give benzoxazolines with quantum yields of 0.07-0.10 in CH2Cl2, 0.02-0.04 in CH3CN, and <0.01 in 30% aq CH3CN. With carboxylate or phenolate leaving groups incorporated via coupling to a 5-hydroxymethyl group of the quinones, the photocyclizations give benzoxazolines that eliminate the leaving groups in a dark reaction. Lifetimes for elimination of 4-YC6H4OH in 30% phosphate buffer in CD3CN (pD 7) at 17 degrees C are 13.1, 0.54, and 0.13 h for Y = H, CF3, and CN, respectively, and the linear equation log k (h(-1)) = 0.998(-pKa) + 8.80 gives a best fit to the data. Carboxylate leaving groups are rapidly eliminated upon photolysis of the quinones in aq CH3CN to produce an o-quinone methide intermediate that is trapped by 4 + 2 cycloaddition with unreacted starting material or with added 3-(dimethylamino)-5,5-dimethyl-2-cyclohexen-1-one. The ortho-quinone methide is observed at 339 and 455 nm by conventional absorption spectroscopy and gives a pseudo-first-order fit of the decay kinetics with tau1/2 = 34.9 min in 30% phosphate buffer in CH3CN at 20 degrees C.
EXTH-57. IDENTIFICATION OF NOVEL IMMUNE CHECKPOINT MOLECULE IN GLIOMA, LAIR1 (2022)

Abstract BACKGROUND In recent years, emerging evidence indicates that tumor-associated myeloid cells (TAMCs) affect cancer progression. But the molecular mechanisms and signaling pathways involved in the TAMCs’ interaction with extracellular matrix (ECM) and tumor stroma are incompletely understood. Checkpoint inhibition therapy targets immune inhibitory receptors, such as CTLA-4 and PD-1, which have become a major weapon in fighting cancer. These antibodies demonstrate apparent advantages such as being easy to use, broad applicability, and durable clinical response. Leukocyte-Associated Immunoglobulin-like Receptor 1 (LAIR1), also called CD305, a collagen-binding immunoreceptor tyrosine-based inhibition motifs (ITIM)-bearing inhibitory receptor, was identified to present on almost all immune cell populations and overexpressed in cancers of human patients. However, LAIR1’s role and regulation in solid cancers are poorly defined. OBJECTIVE To identify LAIR1 as a new class of immune checkpoints in cancers that impacts TAMCs-associated tumor immunity. Further functional investigation warrants understanding the crosstalk between LAIR1-related immune checkpoint blocking agent(s), immune micro-environment, and its underlying mechanisms for targeted therapy development. METHODS Murine GBM cell line KR158-Luciferase cell line was used to set up the mouse model. Tumor-bearing mice were administered the Anti-LAIR1 blockade and IgG, followed by IVIS imaging for tumor growth and survival were recorded. The presentation and phenotype of immune cell populations in tumors and spleens were measured through scRNA-Seq. RESULTS GBM is one of these tumors that overexpress LAIR1 based on the TCGA analysis. LAIR1 molecules express highly on macrophages, monocytes, DCs, and activated T cells, not on the naive T cells. We found that LAIR1 blockade enhanced survival in preclinical GBM models. LAIR1 blockade reduced the presentation and function of TAMCs in tumors. What's more, LAIR1 blockade provided a synergetic antitumor effect with CD70 CAR T cells. CONCLUSION This study suggests that we identified a novel immune checkpoint molecule, LAIR1, which can limit tumor progression.
Identification of a structural constituent and one possible site of postembryonic formation of a teleost otolithic membrane (1997)

A gelatinous otolithic membrane (OM) couples a single calcified otolith to the sensory epithelium in the bluegill sunfish (Lepomis macrochirus) saccule, one of the otolithic organs in the inner ear. Though the OM is an integral part of the anatomic network of endorgan structures that result in vestibular function in the inner ear, the identity of the proteins that make up this sensory accessory membrane in teleosts, or in any vertebrate, is not fully known. Previously, we identified a cDNA from the sunfish saccular otolithic organ that encoded a new member of the collagen family of structural proteins. In this study, we examined biochemical features and the localization of the saccular collagen (SC) protein in vivo using polyclonal antisera that recognize the noncollagenous domains of the SC protein. The SC protein, in vivo, was identified as a 95-kDa glycoprotein in sunfish whole-saccule lysate and in homogenates of microdissected saccular OMs. Immunohistochemical analyses demonstrated that the SC protein was localized within one of the two distinct layers of the sunfish saccular OM. The SC protein was also detected within the cytoplasm of supporting cells at the edges of the saccular sensory epithelium, indicating that these cells are a primary site for the synthesis of this structural protein. Further studies of the organization of this matrix molecule in the OM may help clarify the role of this sensory accessory membrane in vestibular sensory function.
A Graphical Method to Evaluate Multi-Reservoir Commingling (2014)

Abstract Commingling technique is one of the completion design methods that have been used in many oil fields to increase oil production. This technique is used mainly when pay zones have similar rock and oil properties. Previously in vertical wells, commingling was done by opening pay zones to the well bore, but recently specially in horizontal and multi-lateral technology, commingling is achieved by drilling many lateral holes into the pay zones from the same main hole, and producing all of them at the same time. Before deciding on the commingling, some situations need to be addressed before deciding on whether it is optimum to commingle all or some of zones together or not. In this paper, a graphical method has been proposed to assist on the commingling decision by evaluating two completion scenarios and analyze both of them graphically. This method is focused mainly on the effect of the bubble point pressure rather than the other factors because it has a major impact on the productions especially if the commingled zones have different values. The study concluded that commingling decision becomes more likely when the commingled zones have similar saturation pressure; and vice versa. It also concluded that commingling decision becomes more likely when the zone that has the highest value of saturation pressure is deeper than the rest of the pay zones or it has a higher productivity index as compared to the rest of pay zones.
Fast Charge and High Stability of Solid‐State Graphite Organic Ionic Plastic Crystal Composite Anodes (2022)

Abstract All‐solid‐state batteries (ASSBs) using organic ionic plastic crystals (OIPCs) are promising candidates to overcome the inherent safety issues of lithium‐ion batteries (LIBs). Although OIPCs have excellent process applicability in the roll‐to‐roll electrode fabrication process, their application as solid electrolytes incorporated in composite electrodes has yet to be demonstrated in detail. Herein, we denote the positive effect of the N ‐ethyl‐ N ‐methylpyrrolidinium bis(fluorosulfonyl)imide ([C 2 mpyr][FSI]) incorporated within a composite graphite anode on the charge rate capability and cycle life. The highest charge capacity ratio (the charge capacity at 2C vs. that measured at 0.1C) was measured for the composite anode with an OIPC composite ratio of 50 wt % (89.5 %, 295.7 mAh/g at 2C charge), almost the same as that of the graphite anode with a liquid electrolyte (85.7 %, 295.9 mAh/g at 2C charge). More favorable lithium‐ion conduction pathways were resolved for the anode with a higher OIPC composite ratio, whereas an excessive amount of OIPC reduced the long‐term cyclability. The most stable discharge capacity retention was obtained for 30 wt % OIPC composite (257.4 mAh/g at the 100th discharge), which showed no signs of discharge capacity fading within 100 cycles. The lithiation/delithiation process of the solid‐state graphite‐[C 2 mpyr][FSI] composite anode was evaluated to be stable and reversible. In addition, the incorporated OIPC composite enhanced the electrolyte/electrode and electrode/current collector contacts. This work highlights multiple advantageous functions of the OIPC in a composite graphite anode, which will broaden our horizons for the use of OIPC composites in ASSBs.
Segmentation of GPR Images (2006)

In this paper the threshold segmentation rules for GPR data are considered. Bayesian and conditional extremum approaches are used for choosing the threshold. The suggested approaches are compared using both model and real GPR data. The results of the image segmentation are given
Electrodeposited Pd/Ni/Si micro-channel plate electrode for hydrogen peroxide detection and application (2012)

A novel method to construct a sensitive amperometric sensor for hydrogen peroxide (H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) is described. It is composed of highly dispersed palladium nanoparticles on a vertically aligned nickel-coated silicon micro-channel plate (MCP). The morphology of the Pd/Ni/Si-MCP electrode is characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The electrode with a three-dimensional structure shows high-catalytic activity towards oxidation of H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> in a 0.10 M KOH solution. The electrode boasts a high sensitivity of 0.86 mAmM <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> at an applied potential of 0.12V, and the detection limit is 7.6μM. The linear range is up to 12.5mA with a linear correlation of 0.99923. In addition, the electrode also exhibits superior stability, anti-interference, and selectivity. These features demonstrate the Pd/Ni/Si-MCP electrode is suitable for detection of H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> .
Targeting Glucocorticoid Metabolism in Prostate Cancer (2021)

In the treatment of metastatic prostate cancer, resistance to hormonal therapy is a major obstacle. With antiandrogen therapies that suppress androgen signaling through the androgen receptor (AR), the primary driver of prostate cancer, some malignancies are able take advantage of the closely related glucocorticoid receptor (GR). Escape from AR dependency often involves a simple functional switch from 1 steroid receptor to another. Recent research efforts have outlined the mechanism enabling this switch, which involves alterations in glucocorticoid metabolism that occur with antiandrogen therapy to increase tumor tissue glucocorticoids and enable GR signaling. Targeting this mechanism pharmacologically by blocking hexose-6-phosphate dehydrogenase shows promise in normalizing glucocorticoid metabolism and restoring responsiveness to antiandrogen therapy. This perspective reviews what we have learned about this resistance mechanism, examines potential implications, and considers how this knowledge might be harnessed for therapeutic benefit.
Analysis of influence factors of mental health in high school students. (2003)

Objective To explore the influential factors of mental health level in high school students. Methods: A total of 548 high school students were studied with Symptom Check List 90(SCL- 90),Self-Rating Depression Scale(SDS),Self-Rating Anxiety Scale(SAS)and self-made questionary scale on general items. Results:The positive rates in SDS was 25.73% ,18.43% in SAS. 12.77% of subjects'scores were more than 3(middle degree)in at least one factor in SCL-90.The all scores in subjects were significantly different from those in the norms of youny Chinese. The educational level of students and their fathers and the fathers'educational ways had great influence on the scores.Conclusions:Most problems of mental heath in high school students were depression, anxiety, hostility etc,should be paid more attention to.
BioTile, A Perl based tool for the identification of differentially enriched regions in tiling microarray data (2013)

BioTile represents an easy to use analysis option applicable to multiple microarray platforms, allowing for its integration into the analysis workflow of array data analysis.
Driving denaturation: Nanoscale thermal transport as a probe of DNA melting (2011)

DNA denaturation has been a subject of intense study due to its relationship to DNA transcription and its fundamental importance as a nonlinear structural transition. Many aspects of this phenomenon, however, remain poorly understood. Existing models fit quite well with experimental results on the fraction of unbound base pairs versus temperature, but yield incorrect results for other essential quantities such as the base pair fluctuation time scales. Here we demonstrate that nanoscale thermal transport can serve as a sensitive probe of the underlying microscopic physics responsible for the dynamics of DNA denaturation. Specifically, we show that the heat transport properties of DNA are altered significantly as it denatures, and this alteration encodes detailed information on the dynamics of thermal fluctuations and their interaction along the strand. This finding allows for the discrimination between models of DNA denaturation and will help shed new light on the nonlinear vibrational dynamics of this important molecule.
Purdue's Center for Technology Roadmapping: a resource for research and education in technology roadmapping (2003)

Strategic thinking has moved from developing strategies for fixed environments to creating strategies that enable organizations to adapt to and benefit from change. This trend is a reaction to the increasingly dynamic nature of a global economy driven by rapid advances in technology. In response to this trend, Purdue University has created the Center for Technology Roadmapping (CTR). The Center's goal is to enhance strategic planning by advancing the art and science of technology planning. A key feature of the center is a website at which industry associations, research organizations, and individuals can develop roadmaps that are stored in a common data format and posted for public access. As this archive of roadmaps grows, many unique opportunities will arise. In the area of roadmapping research, these include: data-mining across roadmaps from different industries; development of an ontology for technology roadmapping; and analyzing the dynamics of roadmaps over time. In the area of education, these opportunities include: new tools and topics for courses in technology planning and management; the use of roadmapping tools and techniques in undergraduate design courses; an Executive Masters program in technology roadmapping; and broader dissemination of technology information throughout society.
Translucency of Human Dental Enamel (1981)

Translucency of human dental enamel was determined by total transmittance of wavelengths from 400 to 700 nm. The transmission coefficient at 525 nm was 0.481 mm -1 . Total transmission of light through human dental enamel increased with increasing wavelength. Human tooth enamel is more translucent at higher wavelengths. The translucency of wet human enamel and enamel after dehydration was also measured by total transmittance. The transmission coefficient at 525 nm decreased from 0.482 to 0.313 mm -1 after dehydration and was reversed on rehydration. The decrease in translucency occurred as a result of the replacement of water around the enamel prisms by air during dehydration.
Influence of diet on lipid oxidation and membrane structure in porcine muscle microsomes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of diet on lipid oxidation and membrane structure in porcine muscle microsomesFrank J. Monahan, J. Ian Gray, Ali Asghar, Alfred Haug, Gale M. Strasburg, D. Joseph Buckley, and Patrick A. MorrisseyCite this: J. Agric. Food Chem. 1994, 42, 1, 59–63Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/jf00037a009https://doi.org/10.1021/jf00037a009research-articleACS PublicationsRequest reuse permissionsArticle Views171Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Anionic polymerization of dienyl methacrylates (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnionic polymerization of dienyl methacrylatesGerald D. AndrewsCite this: Macromolecules 1984, 17, 8, 1624–1626Publication Date (Print):August 1, 1984Publication History Published online1 May 2002Published inissue 1 August 1984https://pubs.acs.org/doi/10.1021/ma00138a034https://doi.org/10.1021/ma00138a034research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Iterative Retrospective Recovery of Full Synthetic Aperture Data from Focused Transmissions (2019)

Retrospective Encoding For Conventional Ultrasound Sequences (REFoCUS) enables recovery of the full-synthetic aperture (FSA) dataset from focused transmits while avoiding the drawbacks of single- and virtual-element transmissions. It was recently shown that a regularized inversion approach significantly improves the accuracy of the recovered FSA dataset over the REFoCUS method when applied to a walking-aperture transmit sequence. However, this approach becomes computationally burdensome when applied to walking aperture sequences on larger linear arrays. We present an iterative form of REFoCUS that improves FSA dataset recovery to better handle these cases.