gebhart/patrepeval huggingface dataset:
Theory of band broadening during cycling temperature capillary electrophoresis (2007)

A two-state transport model is presented for cycling temperature CE. In this high-throughput method of mutation detection, the temperature oscillates in time, causing the DNA to periodically transit between an annealed state and a partially melted (denatured) state. The change in state alters the electrophoretic mobility, and the presence of a mutation changes the temperature dependence of the denaturing/annealing kinetics. Asymptotic formulae for the mean velocity and effective diffusivity (dispersivity) of the DNA are computed by a multiple-time scales scheme in the limit where the DNA have experienced many temperature cycles before reaching the detector. Explicit analytical results are presented for the case where the temperature cycle consists of one interval with irreversible annealing, followed by a second interval with an infinitely fast, irreversible denaturation. The lag in the annealing leads to a reduction in the mean velocity and an enhanced dispersion compared to the idealized case where the DNA respond instantaneously to the changes in temperature, with the dispersion scaling quadratically with the electric field. The predicted plate height scales linearly with the electric field, and the optimal separation resolution is predicted for moderate values of the cycle frequency that allow the DNA to relax during each temperature oscillation.
Real-time scheduling co-processor in hardware for single and multiprocessor systems (2002)

Multiprocessor real-time systems are difficult to design to achieve predictable time behaviour. Our approach to simplification of the design and timing analysis is to use a scheduling coprocessor. We present the real-time services provided by the coprocessor as well as its implementation and timing. The scheduling coprocessor is a specially designed digital chip and is called the Real-Time Unit (RTU) with latency in the /spl mu/s domain.
Biodiversity of soil cyanobacteria in the hyper‐arid Atacama Desert, Chile (2014)

The cyanobacterial diversity of soils of the Atacama Desert (Chile) was investigated using 16S rRNA gene cloning/sequencing directly from soil samples and 16S rRNA gene sequencing from unialgal cultures. Within the hyper-arid Atacama Desert, one of the driest parts of the world, 10 sites with differing altitude and distance to the shore were sampled along a total air-line distance (from south to north) of ~1,100 km. Filamentous cyanobacteria belonging to Nostocophycideae and Synechococcophycideae were present. Oscillatoriophycideae exhibited the highest species richness among the subclasses of cyanobacteria, and included mostly filamentous species along with some coccoids (e.g., Chroococcidiopsis). Thirty species-level phylotypes could be recognized using a cut-off of 99% 16S rRNA sequence similarity within the 22 genera defined at 97% 16S rRNA sequence similarity. Eight of the 30 taxa could be detected by both clonal and culture sequences. Five taxa were observed only in cultures, whereas the cloning approach revealed 17 additional taxa, which might be in the collection but unsequenced, hard-to-cultivate, or entirely unculturable species using standard cultivation media. The Atacama Desert soils have a high diversity of phylotypes, among which are likely both new genera and new species awaiting characterization and description.
Radar Backscattering of Intertidal Mudflats Observed by Radarsat-1 SAR Images and Ground-Based Scatterometer Experiments (2010)

This paper presents the variation of the radar backscattering of intertidal mudflats in the west coast of Korea observed by Radarsat-1 synthetic aperture radar (SAR) images and investigates the related factors by an indoor experiment and a field experiment using a ground-based C-band scatterometer. The 15 Radarsat-1 SAR images of the intertidal mudflat near Jebu Island used in this study were all taken at around 6:30 p.m., which is an ideal local time for evaluating the daytime evaporation effects during the 12.4-h tidal cycle. An exposure time map and an evaporation time map of mudflats at the time of each SAR acquisition are calculated based on the tidal records, a digital elevation map generated by the waterline extraction method, and the normalized daily evaporation index. The radar backscattering of the upper intertidal mudflat did not show a monotonic change with evaporation time but a complex pattern. An indoor experiment using a C-band scatterometer on drying mud revealed an M-shaped change (increase-decrease-increase-decrease) of radar backscattering due to various factors that affect dielectric constant and roughness such as the drainage of surface water (increase), evaporation (decrease), mud cracking (increase), and further evaporation (decrease). The variation of backscattering observed from SAR images agreed well with the initial three stages of the indoor experiment (increase-decrease-increase) but did not show the final stage of decrease from continuous evaporation. A field experiment on natural intertidal mudflats showed not only the pattern related to the initial drainage and evaporation but also speckles from biological activity.
[The mechanism of cataract formation in persons with beta-thalassemia]. (1998)

We examined 63 patients with beta-thalassemia whose ages range from 7 to 57 years. Lens opacities were presented in 14 patients--22%. The period these persons had transfusions and were submitted to iron chelating drug--deferoxamine and the concentration of there serum ferritin in the last seven years were noted. Comparing persons with identical ages and transfusion periods we found that patients who were submitted to less chelation therapy patients which started these therapy later and patients with higher values of mean ferritin or with significant picks were in danger to developed cataract. Patients younger of 10 years old didn't developed cataract despite high values of ferritin. All patients after 30 did have lens opacities.
Immortalized neurons for the study of hypothalamic function (2011)

The hypothalamus is a vital part of the central nervous system: it harbors control systems implicated in regulation of a wide range of homeostatic processes, including energy balance and reproduction. Structurally, the hypothalamus is a complex neuroendocrine tissue composed of a multitude of unique neuronal cell types that express a number of neuromodulators, including hormones, classical neurotransmitters, and specific neuropeptides that play a critical role in mediating hypothalamic function. However, neuropeptide and receptor gene expression, second messenger activation, and electrophysiological and secretory properties of these hypothalamic neurons are not yet fully defined, primarily because the heterogeneity and complex neuronal architecture of the neuroendocrine hypothalamus make such studies challenging to perform in vivo. To circumvent this problem, our research group recently generated embryonic- and adult-derived hypothalamic neuronal cell models by utilizing the novel molecular techniques of ciliary neurotrophic factor-induced neurogenesis and SV40 T antigen transfer to primary hypothalamic neuronal cell cultures. Significant research with these cell lines has demonstrated their value as a potential tool for use in molecular genetic analysis of hypothalamic neuronal function. Insights gained from hypothalamic immortalized cells used in conjunction with in vivo models will enhance our understanding of hypothalamic functions such as neurogenesis, neuronal plasticity, glucose sensing, energy homeostasis, circadian rhythms, and reproduction. This review discusses the generation and use of hypothalamic cell models to study mechanisms underlying the function of individual hypothalamic neurons and to gain a more complete understanding of the overall physiology of the hypothalamus.
Ein vielseitiger Weg zu porösen Feststoffen: organisch-anorganische Hybridmaterialien, die sich über H-Brücken aufbauen (1999)

Quadratisch-planare und oktaedrische Komplexe von Nickel(II) und Platin(II) verknüpfen sich über Kopf-Kopf-Wasserstoffbrückenbindungen unter Bildung poröser Gerüste mit großen Hohlräumen, die Gastmoleküle aufnehmen können. Vier verschiedene Komplexe mit Liganden auf Pyridinbasis (in der Mitte des Bildes gezeigt) werden vorgestellt, die entweder Gegenionen oder kleine Moleküle in Kanälen enthalten. A = H-Brücken-Acceptor, D = H-Brücken-Donor, M = Metallion.
A Two-stage Vehicle Type Recognition Method (2018)

Vehicle type recognition is a common question in modern intelligent transportation system. Although many methods have been proposed in literatures, how to recognize the vehicle type in the case of small samples is still troubling. To solve the problem mentioned above, this paper presents a method for vehicle type recognition based on a two-stage strategy that includes data preprocessing phrase and training phrase. The main purpose of the first stage is to remove the background of the vehicle image to reduce the interference of redundant information on subsequent stage. In second stage, a concept of multi-scale fusion feature which integrates handcrafted features with learning-based feature is to put forward to describe the characteristics of vehicles. The combined features are input to Support Vector Machine with Racial Basis Function (RBF-SVM) to train the recognition model. The proposed method is tested on MVVTR and the recognition accuracy is up to 90.96%, which is better than other methods. It is verified that strong generalization ability can be achieved in the case of small samples by using the two- stage strategy.
Multiple GTP-binding proteins from cholinergic synaptic vesicles (1990)

Cholinergic synaptic vesicles purified from the electric organ of the marine ray, Discopyge ommata, contain 2 different size classes of GTP-binding proteins: one or more with an apparent molecular weight (MW) between 37 and 41 kDa, and 3 major and at least 2 minor proteins with MW between 20 and 29 kDa. These GTP-binding proteins were detectable using the alpha 32P-GTP overlay technique and covalent modification with bacterial toxins. The higher MW GTP-binding proteins are ADP-ribosylated by pertussis toxin and 2 of the lower MW GTP-binding proteins are sensitive to botulinum toxin.
Cladded radially inhomogeneous sphere lenses (1981)

When a radially inhomogeneous sphere is cladded with an additional refractive-index medium, the spherical transverse aberration of a resultant lens is minimized in order to image a point light source in the diffraction-limited spot size for a lens a few millimeters in diameter with ~0.4 N.A. Examples of numerical data used in designing such sphere lenses are given for three different cases: imaging, Fourier transform, and optical disk reading. Various uses of these lenses are also envisioned for demonstrating their potential usefulness.
ChemInform Abstract: OX. VON AMINEN UND CHEMIE VON CHINONIMINEN 2. MITT. 2,5‐DIMETHOXY‐4‐TERT.‐BUTYL‐ANILIN (1972)

Abstract Die Oxidation des Anilins (I) mit K‐hexacyanoferratGII) bzw. Ag‐oxid in alkalischem Medium liefert Gemische des Azobenzols (II) (Ausbeute 14‐15%) mit dem Phenazin (III) (14 bzw. 37%).
Nonmetal Elements and Compounds (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNonmetal Elements and CompoundsW. E. Haines and D. R. LathamCite this: Anal. Chem. 1979, 51, 5, 231–238Publication Date (Print):April 1, 1979Publication History Published online1 May 2002Published inissue 1 April 1979https://pubs.acs.org/doi/10.1021/ac50041a022https://doi.org/10.1021/ac50041a022research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Innovative Technique for HPA Characteristics Extraction and Accurate Predistorsion Function Modeling (2019)

In telecommunications, the combination of modulations with non-constant envelope together with nonlinearities leads to strong distortions of the transmitted signals. The linearization purpose is to assure an optimal link transmission quality. In this article, an innovative method to extract linearization characteristics is presented. This technique, using directly experimental data rather than a High Power Amplifier (HPA) modeling, is fast and allows an important linearization accuracy and computational workload improvement compared to classical modeling techniques. It is then applied to determine the ideal linearizer AM/AM and AM/PM transfer characteristics to exploit three real HPA to their fullest.
Relationship between steroid receptors and response to endocrine therapy and cytotoxic chemotherapy in metastatic breast cancer (1980)

The relationship between steroid receptor content and response of metastatic breast cancers to endocrine therapy and cytotoxic chemotherapy has been examined. In 54 advanced breast cancers treated with hormonal therapy, 20 of 29 (69%) ER+, PR+ and 3 of 14 (21%) ER+, PR- tumors responded. Of the nine tumors that lacked both ER and PR, 2 (22%) were hormonally responsive. Based on either the ER or PR content alone, 68% of the PR+ and 54% of the ER+ tumors responded to endocrine therapy. Thus, the addition of PR assay could improve the accuracy of ER assay in selecting a hormonally responsive breast cancer. In 29 advanced breast cancers treated with cytotoxic drugs, the presence of ER and/or PR in the tumors seemed to favor an objective response to cytotoxic chemotherapy. The response rate was about 67% regardless of whether the cancers were ER+ or PR+.
Control of Foxp3 stability through modulation of TET activity (2016)

Ten-eleven translocation (TET) enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine and other oxidized methylcytosines, intermediates in DNA demethylation. In this study, we examine the role of TET proteins in regulating Foxp3, a transcription factor essential for the development and function of regulatory T cells (T reg cells), a distinct lineage of CD4+ T cells that prevent autoimmunity and maintain immune homeostasis. We show that during T reg cell development in the thymus, TET proteins mediate the loss of 5mC in T reg cell–specific hypomethylated regions, including CNS1 and CNS2, intronic cis-regulatory elements in the Foxp3 locus. Similar to CNS2-deficient T reg cells, the stability of Foxp3 expression is markedly compromised in T reg cells from Tet2/Tet3 double-deficient mice. Vitamin C potentiates TET activity and acts through Tet2/Tet3 to increase the stability of Foxp3 expression in TGF-β–induced T reg cells. Our data suggest that targeting TET enzymes with small molecule activators such as vitamin C might increase induced T reg cell efficacy.
Advanced sensing and imaging for efficient energy exploration in complex reservoirs (2020)

The oil and gas industry continuously struggles to cope with the high cost of production in the context of competitive worldwide market prices. Low oil and gas prices backstop an economic situation where exploration and exploitation of complex reservoirs are hindered. Exploration and production of complex reservoirs face several challenges. Despite having subsurface information from geological models and seismic images, they are prone to uncertainties, and as a consequence, the development and production of such reservoirs are not optimal. Here, we focus on advanced sensing methodologies that are tailored to complex unconventional reservoirs, such as the heavy oil reservoirs in Canada. Further refinement of reservoir extent, hosted oil, and geological properties can potentially increase production rate, decrease the costs and risks of drilling, alleviate well placement issues, and improve the management and monitoring of reservoir — overall leading to lower uncertainty on developing the resource. We introduce new workflows for smart drilling and optimal well placement by taking advantage of the seismic-while-drilling imaging approach. The proposed framework provides high-resolution images of the subsurface thanks to new advancements in seismic remote sensing, signal processing, and imaging.
The Hazards in Segmentation of Handwritten Hindi Text (2011)

Optical Character Recognition (OCR) is a process to recognize the handwritten or printed scanned text with the help of a computer. Segmentation is very important stage of any text recognition system. The problems in segmentation can lead to decrease in segmentation rate and hence recognition rate. A good segmentation technique can improve the recognition rate. This paper deals with the hazards that occur in segmentation of handwritten Hindi text. We also explained the main reasons for some of these problems.
Mismatch-induced bit error rate in optical chaos communications using semiconductor lasers with electrooptical feedback (2005)

We analyze the influence of parameter mismatch between emitter and receiver systems on the bit error rate of an optical chaos communication scheme. Intensity hyperchaos is generated in the system by semiconductor lasers with electrooptical feedback. We find analytical predictions for the dependence of the bit error rate with the amplitude of the various mismatches and the statistical properties of the hyperchaotic carrier. A good concordance is found with numerical and experimental results.
102-05: A new type of intracardiac minipropeller synchronized on ventricular contraction considered as an innovative generation of Ventricular Assist Device (VAD): early animal results (2016)

Purpose of the study: To assess the efficacy of a new concept of intracardiac propeller to restore a normal cardiac output in severely altered hearts via a mini-invasive beating heart surgical approach. Methods: A VAD located inside the left ventricle has been developed in order to assist hearts in severe heart failure during the systolic phase. The concept is based on alternative rotation speeds of a specifically designed propeller (length:40mm, diameter:18mm) according to the diastolic and systolic heart phases. Synchronization of the assist device is provided by a programmable identification of the aortic valve opening and closure, in order to automatically respect the cardiac cycle and the physiological ascendant ejection native systolic flow. In-vitro and in-vivo acute animal studies have been achieved. Results: In-vitro studies have demonstrated that cardiac output could be increased from 40% to more than 100%, which was confirmed in 6 sheep with an acute severe heart failure model. The device is well tolerated from 2000 to 8000 rpm and able to identify arrhythmias in order to be switched on in continuous mode in case of ventricular tachycardia or fibrillation. Since the electric consumption is low (< 5 watts), this VAD will be powered via a transcutaneous energy transfer technology without any external cable.
Interstitial-nitrogen effect on phase transition and magnetocaloric effect in Mn(As,Si) (invited) (2010)

The effect of interstitial nitrogen on the phase transition and magnetocaloric behavior of MnAs1−xSixNδ (x=0.03, 0.06, and 0.09) is investigated. The interstitial nitrogen atoms cause the step-scanned x-ray diffraction peaks to shift toward lower angles and lower the Curie temperature, whereas silicon addition increases the Curie temperature to near room temperature. The thermal hysteresis is reduced to nearly 0 in MnAs1−xSixNδ, which is beneficial to practical applications. For a field change of 5 T, the largest magnetic entropy change and refrigerant capacity are 14.6 J kg−1 K−1 at 247 K and 360 J kg−1, which is slightly higher than the entropy change in the parent alloy. Finally, we briefly discuss the occurrence and origin of the “virgin effect” in MnAs.
PTH Modulation by Aldosterone and Angiotensin II is Blunted in Hyperaldosteronism and Rescued by Adrenalectomy (2019)

Abstract Context Accumulating evidence suggests a link between adrenocortical zona glomerulosa and parathyroid gland through mechanisms that remain unexplored. Objectives To test the hypothesis that in vivo angiotensin II blockade affects PTH secretion in patients with hypertension and that aldosterone and angiotensim II directly stimulate PTH secretion ex vivo. Design and Setting We investigated the changes of serum PTH levels induced by oral captopril (50 mg) administration in patients with primary essential hypertension (EH) and with primary aldosteronism (PA) caused by bilateral adrenal hyperplasia (BAH) or aldosterone-producing adenoma (APA), the latter before and after adrenalectomy. We also exposed primary cultures of human parathyroid cells from patients with primary hyperparathyroidism to angiotensin II (10−7 M) and/or aldosterone (10−7 M). Results Captopril lowered PTH levels (in nanograms per liter) both in patients with EH (n = 63; 25.9 ± 8.3 baseline vs 24.4 ± 8.0 postcaptopril, P &lt; 0.0001) and in patients with APA after adrenalectomy (n = 27; 26.3 ± 11.6 vs 24.0 ± 9.7 P = 0.021). However, it was ineffective in patients with full-blown PA caused by APA and BAH. In primary culture of human parathyroid cells, both aldosterone (P &lt; 0.001) and angiotensin II (P = 0.002) markedly increased PTH secretion from baseline, by acting through mineralocorticoid receptor and angiotensin type 1 receptor, as these effects were abolished by canrenone and irbesartan, respectively. Conclusion These results collectively suggest an implication of the renin-angiotensin-aldosterone system in PTH regulation in humans, at least in PTH-secreting cells obtained from parathyroid tumors. Moreover, they further support the concept that mild hyperparathyroidism is a feature of human PA that is correctable with adrenalectomy.
Iridoid glucosides and anthraquinone from the aerial parts of Saprosma fragrans (2012)

Department of Chemistry, K. S. Saket P.O. College, Dr. Ram Manohar Lohia Avadh University, Faizabad-224 001, Uttar Pradesh, India <em>E-mail</em> : dnsinghsaket@yahoo.com <em>Manuscript received 10 March 2011, accepted 20 June 2011</em> Paederoside, paederosidic acid, 1,3-dimethoxyanthraquinone-2-carboxylic acid and β-sitosteroi-D-glucoside have been isolated from the ethanolic extract of the aerial parts of <em>Saprosma fragrans</em> and their structures were established by spectral evidences and chemical studies. This is the first report of iridoid glucosides, paederoside and paederosidic acid containing rarely encountered S-methyl thiocarbonate moiety, 1 ,3-dimethoxyanthraquinone-2-carboxylic acid and β-sitosterol-D-glucoside in <em>S. fragrarzs</em>. The identities of isolated iridoid glucosides were also verified by detailed spectral data (UV, IR, FAB-MS, <sup>1</sup>H NMR and <sup>13</sup>C NMR) analyses of acetate derivatives of paederoside and paederosidic acid prepared by the acetylation of the respective iridoid glucosides.