gebhart/patrepeval huggingface dataset:
Metal-mediated formation of liquid crystals: synthesis, structural and thermal analysis of palladium(ii) complexes of crown thioether derivativesElectronic supplementary information (ESI) available: Figs. 1–3 with full captions, Fig. 4: view of the packing of [Pd(7)][BF4]2. Fig. 5: schematic of undulating layers in [Pd(7)][BF4]2. See http://www.rsc.org/suppdata/cc/b1/b107027b/ (2001)

Oligo(benzoate) derivatives of cis- and trans-(RO)2[14]aneS4, trans-(RO)2[16]aneS4, and their corresponding Pd(II) complexes reveal metal-induced mesomorphic behaviour which can be rationalised by conformational locking of the ligand on complexation.
<title>Fast inversion scheme for the linearized problem in optical absorption tomography on objects with radially symmetric boundaries</title> (1996)

We present a reconstruction scheme which solves the inverse linear problem in optical absorption tomography for radially symmetric objects. This is a relevant geometry for optical diagnosis in soft tissues, e.g. breast, testis and even head. The algorithm utilizes an invariance property of the linear imaging operator in homogeneously scattering media. The inverse problem is solved in the Fourier space of the angular component leading to a considerable dimension reduction which allows to compute the inverse in a direct way using singular value decomposition. There are two major advantages of this approach. First the inverse operator can be stored in computer memory and the computation of the inverse problem comprises only a few matrix multiplications. This makes the algorithm very fast and suitable for parallel execution. On the other hand we obtain the spectrum of the imaging operator that allows conclusions about reconstruction limits in the presence of noise and gives a termination criterion for image synthesis. To demonstrate the capabilities of this scheme reconstruction results from synthetic and phantom data are presented.
The Design of Burglar Alarm Circuit Based on the Magnetic Field Sensor (2012)

This paper introduces a design method and a hardware circuit of burglar alarm circuit based on the magnetic field sensor, which can be used to achieve the protection of valuables. The circuit design is ingenious, and has the characteristics of simple structure, light weight, small size, timeliness, high sensitivity and low cost. It has been proved to have a stable and reliable performance by experiment.
A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells. (1990)

Our previous study suggested that N,N-dimethylsphingosine, but not unsubstituted sphingosine, could be a modulator of protein kinase C in epidermoid carcinoma A431 cells, since N,N-dimethyl-D-erythrosphingenine showed a stronger stereospecific effect on protein kinase C activity in comparison with N,N-dimethyl-L-erythrosphingenine, unsubstituted D- or L-erythrosphingenine, and gangliosides (Igarashi, Y., Hakomori, S., Toyokuni, T., Dean, B., Fujita, S., Sugimoto, M., Ogawa, T., El-Ghendy, K., and Racker, E. (1989) Biochemistry 28, 6796-6800). Other studies also indicated that commercial sphingosine preparation has an enhancing effect on epidermal growth factor (EGF) receptor kinase activity in A431 cells (Davis, R. J., Girones, N., and Faucher, M. F. (1988) J. Biol. Chem. 263, 5373-5379; Faucher, M. F., Girones, N., Hannun, Y. A., Bell, R. M., and Davis, R. J. (1988) J. Biol. Chem. 263, 5319-5327). In the present paper, we report (i) the effect of N,N-dimethylsphingosine as compared with lyso-glycosphingolipids and other sphingolipid breakdown products on EGF receptor autophosphorylation and (ii) demonstration of endogenous N,N-dimethylsphingosine synthesis and the virtual absence of unsubstituted sphingosine in A431 cells. The autophosphorylation of EGF receptor in the absence of detergent was strongly enhanced by N,N-dimethyl-D-erythrosphingenine; this effect was even obvious in the absence of EGF and synergistic in the presence of EGF. Similar enhancing activity was not produced by N,N-dimethyl-L-erythrosphingenine, D- and L-erythrosphingenine, N-monomethyl-D-erythrosphingenine, N-acetyl-D-erythrosphingenine, or the five lyso-glycosphingolipids tested. Labeling of sphingosine in A431 cells by culturing in medium containing [3H]Ser for various durations, followed by extraction and isolation of sphingolipids by standard procedures, resulted in clear bands corresponding to N,N-dimethylsphingosine and ceramide, whereas the band corresponding to sphingosine was virtually absent. The bands corresponding to N,N-dimethylsphingosine and ceramide intensified when cells were treated with metabolic inhibitor for UDP-Glc:Cer beta-Glc transferase (which causes accumulation of ceramide). These results indicate that N,N-dimethylsphingosine acts as a stereospecific enhancer for EGF receptor kinase and is able to produce EGF-like activity in vitro even in the absence of EGF and detergent. Under physiological conditions, N,N-dimethylsphingosine is the major catabolite resulting from ceramide breakdown.
Novel Bronchodilators:  Synthesis, Transamination Reactions, and Pharmacology of a Series of Pyrazino[2,3-c][1,2,6]thiadiazine 2,2-Dioxides (2000)

The synthesis, pharmacological evaluation, and structure-activity relationships of a new class of bronchodilator agents, derivatives of pyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxides are described. The compounds were prepared by reaction of 3,4,5-triamino-1,2, 6-thiadiazine 1,1-dioxide with suitable 1,2-dicarbonyl compounds or alpha-hydroxyiminoketones and subsequent N-alkylation. A transamination procedure for synthesizing derivatives with different substituents at the 4-amino group is reported for the first time. The pyrazino[2,3-c][1,2,6]thiadiazine derivatives were screened for tracheal relaxing activity in vitro, and the active compounds were evaluated in vivo in guinea pigs as bronchodilator agents in comparison to theophylline. Among the compounds studied, the most interesting properties were displayed by the 4-amino-1-ethyl-6-methyl derivative (21). The toxicological evaluation of this derivative is also reported.
Venetoclax and obinutuzumab in chronic lymphocytic leukemia (2017)

To the editor:

In chronic lymphocytic leukemia (CLL), the median age at diagnosis is 72 years, and most patients requiring therapy have coexisting medical conditions. Venetoclax is a potent BH3-mimetic compound that selectively antagonizes BCL-2 and has shown efficacy as monotherapy and with
Simulation of heat and mass transfer processes in molten core debris-concrete systems. [LMFBR] (1979)

The heat and mass transport phenomena taking place in volumetrically-heated fluids have become of interest in recent years due to their significance in assessments of fast reactor safety and post-accident heat removal (PAHR). Following a hypothetical core disruptive accident (HCDA), the core and reactor internals may melt down. The core debis melting through the reactor vessel and guard vessel may eventually contact the concrete of the reactor cell floor. The interaction of the core debris with the concrete as well as the melting of the debris pool into the concrete will significantly affect efforts to prevent breaching of the containment and the resultant release of radioactive effluents to the environment.
Étude du dédoublement des solvates de méthanol (±)-2,4-dichlorophénylacétique-BM par cristallisation préférentielle (2008)

Le solvate de methanol (±)-2,4-dichlorophenylacetate obtenu avec le melange racemique BM, est un derive salin pharmaceutique cristallisant sous forme de conglomerat stable sans aucune solution solide detectable a l'equilibre thermodynamique. L'optimisation de son dedoublement par cristallisation preferentielle a ete realisee a l'echelle 2 litres selon les deux modes : Auto Seeded Programmed Polythermic Preferential Crystallization (AS3PC) et le procede classique : Seeded Isothermal Preferential Crystallization (SIPC). La productivite du systeme [(-)-2,4-dichlorophenylacetate-BM - (+)-2,4-dichlorophenylacetate-BM-Methanol] a ete etudiee. L'etude de la croissance cristalline du solvate de methanol, propose une possible adsorption du contre-eniantiomere en milieu quasi racemique. Permettant ainsi d'expliquer les exces enantiomeriques modestes obtenus au cours du dedoublement.
Comparison of Corticotropin-Releasing Factor, Dexamethasone, and Temozolomide: Treatment Efficacy and Toxicity in U87 and C6 Intracranial Gliomas (2011)

hCRF was more effective than either dexamethasone or temozolomide in the treatment of U87 xenografts, and results included improved prognosis with long-term survivors and only mild toxicity. The therapeutic efficacy of hCRF seems to be dependent on tumor hCRF receptor (CRFr) expression. These results support further clinical assessment of the therapeutic efficacy of hCRF and levels of CRFr expression in different human gliomas.
Homogeneous ruthenium-catalyzed reduction of nitrobenzene (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHomogeneous ruthenium-catalyzed reduction of nitrobenzeneF. L'Eplattenier, P. Matthys, and Fausto CalderazzoCite this: Inorg. Chem. 1970, 9, 2, 342–345Publication Date (Print):February 1, 1970Publication History Published online1 May 2002Published inissue 1 February 1970https://pubs.acs.org/doi/10.1021/ic50084a034https://doi.org/10.1021/ic50084a034research-articleACS PublicationsRequest reuse permissionsArticle Views579Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Dyspnea with hypoxemia in a case of cirrhosis with portal hypertension]. (1985)

Following insertion of a Leveen's valve after surgical portocaval anastomosis, a male patient with alcoholic cirrhosis developed dyspnoea with hypoxaemia. An interstitial syndrome was present in the lower lobes. Other findings were: polycythaemia (Hb 20 g/100 ml), subnormal spirometric values, decrease in CO transfer capacity, normal pulmonary compliance, absence of intracardiac shunt and pulmonary arterial hypertension and absence of bronchial or alveolar lesions on a surgical lung biopsy. Blood gas measurements and radioisotope explorations led to the conclusion that the patient had an anatomical shunt predominant in the lower parts of the lungs, associated with a shunt effect and a transfer disorder. The anatomical shunt was due to pulmonary arteriovenous microfistulae, some of which were visualized by superselective angiography. Catheterization of the portocaval anastomosis eliminated any shunt between the portal system and the pulmonary veins.
Data from A Prospective Study of Nut Consumption and Risk of Primary Hepatocellular Carcinoma in the U.S. Women and Men (2023)

&lt;div&gt;Abstract&lt;p&gt;Although increasing evidence suggests a potential beneficial effect of nut consumption on various diseases, no epidemiologic study has yet examined the association between nut consumption and risk of hepatocellular carcinoma (HCC). We prospectively examined this association in 88,783 women from the Nurses’ Health Study and 51,492 men from the Health Professionals Follow-up Study. Nut consumption was assessed every 4 years using validated food frequency questionnaires. Multivariable HRs and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards regression models after adjusting for HCC risk factors. After an average of 27.9 years of follow-up, we identified a total of 162 incident HCC cases. Higher total nut consumption was not significantly associated with HCC risk (the highest vs. lowest tertile intake, HR, 0.84; 95% CI, 0.56–1.26). For the same comparison, higher tree nut consumption was associated with a lower HCC risk (HR, 0.64; 95% CI, 0.43–0.95). We found nonsignificant inverse associations with consumption of walnuts, peanuts, and peanut butter. Overall, nut consumption was not strongly associated with HCC risk. There was a suggestive inverse association with tree nut consumption. Future studies should carefully consider hepatitis B or C virus infections and examine these associations in other racial/ethnic groups.&lt;/p&gt;&lt;/div&gt;
Interpretation and modeling of buried InAs quantum dots on GaAs and InP substrates (2001)

Comparisons of buried InAs/GaAs and InAs/InP quantum dots (QDs) utilizing transmission electron microscopy display interesting parallels and differences between the two systems. The higher 7.2% misfit in the InAs/GaAs system produces small (∼20 nm diameter) QDs with a majority displaying a predominately round shape. The lower 3.2% misfit in the InAs/InP system produces larger QDs (∼35 nm diameter) with the majority also displaying a predominately round shape. In both systems, the size of the QDs can be varied by changes in growth procedures and the largest QDs in any population show evidence of faceting
InnerView (2016)

In the recent past, there has been interest in characterizing the physical and social ambiance of urban spaces to understand how people perceive and form impressions of these environments based on physical and psychological constructs. Building on our earlier work on characterizing ambiance of indoor places, we present a methodology to automatically infer impressions of place ambiance, using generic deep learning features extracted from images publicly shared on Foursquare. We base our methodology on a corpus of 45,000 images from 300 popular places in six cities on Foursquare. Our results indicate the feasibility to automatically infer place ambiance with a maximum R2 of 0.53 using features extracted from a pre-trained convolutional neural network. We found that features extracted from deep learning with convolutional nets consistently outperformed individual and combinations of several low-level image features (including Color, GIST, HOG and LBP) to infer all the studied 13 ambiance dimensions. Our work constitutes a first study to automatically infer ambiance impressions of indoor places from deep features learned from images shared on social media.
Facet-Dependent Activity of CeO2 Nanozymes Regulate the Fate of Human Neural Progenitor Cell via Redox Homeostasis (2022)

Neural progenitor cells (NPCs) therapy, a promising therapeutic strategy for neurodegenerative diseases, has a huge challenge to ensure high survival rate and neuronal differentiation rate. Cerium oxide (CeO<sub>2</sub>) nanoparticles exhibit multienzyme mimetic activities and have shown the capability of regulating reactive oxygen species (ROS), which is a pivotal mediator for intracellular redox homeostasis in NPCs, regulating biological processes including differentiation, proliferation, and apoptosis. In the present study, the role of facet-dependent CeO<sub>2</sub>-mediated redox homeostasis in regulating self-renewal and differentiation of NPCs is reported for the first time. The cube-, rod-, and octahedron-shaped CeO<sub>2</sub> nanozymes with different facets are prepared. Among the mentioned nanozymes, the cube enclosed by the (100) facet exhibits the highest CAT-like activity, causing it to provide superior protection to NPCs from oxidative stress induced by H<sub>2</sub>O<sub>2</sub>; meanwhile, the octahedron enclosed by the (111) facet with the lowest CAT-like activity induces the most ROS production in ReNcell CX cells, which promotes neuronal differentiation by activated AKT/GSK-3β/β-catenin pathways. A further mechanistic study indicated that the electron density of the surface Ce atoms changed continuously with different crystal facets, which led to their different CAT-like activity and modulation of redox homeostasis in NPCs. Altogether, the different surface chemistry and atomic architecture of active sites on CeO<sub>2</sub> exert modulation of redox homeostasis and the fate of NPCs.
Photon number distribution of detuned two-mode vacuum and excited squeezed states (1992)

Lie-group methods are used for analyzing the photon number distribution of detuned two-mode squeezed states. The effects of the detuning on the vacuum and excited two-mode squeezed states are analyzed and found to be similar to those obtained previously for the degenerate case. Correlations between the radiations in the two modes are described and found to decrease as a function of the detuning parameters.
Electromagnetic and mechanical analysis of high speed SPM rotor with copper shield (2017)

For high-speed applications, the surface-mounted permanent magnet (SPM) machine is preferred due to its high torque density and efficiency. However, induced eddy currents in the rotor conductive parts result in a loss of efficiency and rotor heating. Therefore, several methods to reduce such losses have been proposed in the literature including copper shielding. In this paper, a high-speed SPM machine rotor with a copper shield is designed and investigated both electromagnetically and mechanically. Several quantitative investigations including placing the copper sheet around the retaining sleeve or magnets, different copper sheet and airgap thicknesses, different retaining sleeve materials, different harmonic contents in the current waveform, i.e. pulse amplitude modulation (PAM) and pulse width modulation (PWM) generated waveforms, and different frequencies and current levels are reported. Additionally, a mechanical analysis investigating possible failure modes of the rotor with the copper sheet is reported.
Tapered Floating Point: A New Floating-Point Representation (1971)

It is well known that there is a possible tradeoff in the binary representation of floating-point numbers in which one bit of accuracy can be gained at the cost of halving the exponent range, and vice versa. A way in which the exponent range can be greatly increased while preserving full accuracy for most computations is suggested.
Pose optimization and port placement for robot‐assisted minimally invasive surgery in cholecystectomy (2017)

This research can provide guidelines for surgeons in preoperative preparation.
Selective Hydrolysis of Ethyl 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate and Ethyl 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylate as a Key Step in the Large-Scale Synthesis of Bicyclic Heteroaryl Carboxyaldehydes (2006)

The isomeric mixture of ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2- and −3-carboxylates (14 and 15), derived from a proline meso-ionic synthon, demonstrated remarkably different stabilities towards alkaline hydrolysis. On that basis, a nonchromatographic, highly efficient method for their large-scale separation was developed. The desired isomer 14 was converted into 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carbaldehyde, a key intermediate in the synthesis of bicyclic heteroaryl-substituted 6-alkylidene penems.
ChemInform Abstract: Homolytic and Heterolytic Scission of Organic Hydroperoxides by (meso‐Tetraphenylporphinato)iron(III) and Its Relation to Olefin Epoxidation. (1989)

Abstract The products (II) and (III) are obtained from the hydroperoxide (I) by homolytic cleavage via a common alkoxyl radical.
Clinical, histologic, and electron microscopy study of skin exposed to low‐frequency ultrasound (2001)

The use of low-frequency ultrasound has been proposed to enhance the transdermal transport of various drugs, a technique referred to as sonophoresis. The aim of the present study was to determine the safety of low-frequency sonophoresis on human and rat skin by evaluating their structural modifications after ultrasound exposure. Human skin samples and hairless rats were exposed to 20 kHz ultrasound in vitro and in vivo, respectively. Ultrasound was used with average intensities ranging from 0.25 to 7 W/cm(2) in pulsed or continuous mode. Hairless rats were also exposed to a heat source mimicking the temperature versus time profile during sonication. Skin samples were observed under optical and electron microscopy to detect any structural changes. Human skin samples exposed to intensities lower than 2.5 W/cm(2) showed no modification. For hairless rats, slight and transient erythema was observed after 2.5 W/cm(2) exposure, whereas deep lesions (dermal and muscle necrosis) were observed 24 hr later. These lesions were also observed when a plastic film was placed between the coupling medium and the animals' skin during sonication. In contrast, no histologic lesion could be seen when a heat source was applied to animal skin. Low-frequency ultrasound induces delayed and deep lesions in hairless rat skin at 2.5 W/cm(2) which are not only attributable to the increase in temperature at the skin surface during ultrasound exposure. By using the same ultrasound conditions, human skin seems to be less sensitive in vitro.
ChemInform Abstract: Reductive Elimination of Chlorine from Dichlorotellurium(IV) Compounds. Kinetic Studies in Tetrachloroethane and Acetonitrile. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
医疗器械可沥滤物安全性研究（三）：允许限量建立 (2019)

随着新材料、新设计等创新性医疗器械产品的不断涌现，可沥滤物的安全性研究也面临新的挑战，其中可沥滤物允许限量的建立是医疗器械安全性评价研究的重要方面。结合现有产品的审评，简述高分子医疗器械可沥滤物安全性研究中允许限量的建立环节中的常见问题，并对其原因进行解析，供相关机构及研发人员参考使用。
A Statistical Analysis of Recent Traffic Crashes in Massachusetts (2019)

A statistical analysis implemented in the Python programming language was performed on the available MassDOT car accident data to identify whether a certain set of traffic circumstances would increase the likelihood of injuries. In the analysis, we created a binary classifier as a model to separate crashes that resulted in injury from those that did not. To accomplish this, we first cleaned up the initial data, then proceeded to represent categorical variables numerically through one hot encoding before finally producing models with Recursive Feature Elimination (RFE) and without RFE, in conjunction with logistic regression. This statistical analysis plays a significant role in our modern road network that has presented us with a heap of obstacles, one of the most critical being the issue of how we can ensure the safety of all drivers and passengers. Findings from our analysis identify that tough weather and road conditions, senior/teen drivers and dangerous intersections play prominent roles in accidents that resulted in injuries in Massachusetts. These new findings can provide valuable references and scientific data support to relevant authorities and policy makers for upgrading road infrastructure, passing regulations, etc.