gebhart/patrepeval huggingface dataset:
EUV mask and wafer defectivity: strategy and evaluation for full die defect inspection (2016)

Over the past few years numerous advancements in EUV Lithography have proven its feasibility of insertion into High Volume Manufacturing (HVM).<sup>1, 2</sup> A lot of progress is made in the area of pellicle development but a commercially solution with related infrastructure is currently unavailable.<sup>3, 4</sup> Due to current mask structure and unavailability of a pellicle, a comprehensive strategy to qualify (native defects) and monitor (adder defects) defectivity on mask and wafer is required for implementing EUV Lithography in High Volume Manufacturing. In this work, we assess multiple strategies for mask and wafer defect inspection including a two-fold solution to leverage resolution of e-beam inspection along with throughput of optical inspection are evaluated. Defect capture rates for inspections based on full-die, critical areas based on priority and hotspots based on design and prior inspection data are evaluated. Each strategy has merits and de-merits, particularly related to throughput, effective die coverage and computational overhead. A production ready EUV Exposure tool was utilized to perform exposures at the IBM EUV Center of Excellence in Albany, NY for EUV Lithography Development along with a fully automated line of EUV Mask Infrastructure tools. We will present strategies considered in this study and discuss respective results. The results from the study indicate very low transfer rate of defect detection events from optical mask inspection. They also suggest a hybrid strategy of utilizing both optical and e-beam inspection can provide a comprehensive defect detection which can be employed in High Volume Manufacturing.
Industrial production of heterologous proteins by fed-batch cultures of the yeastSaccharomyces cereuisiae (1994)

This review concerns the issues involved in the industrial development of fed-batch culture processes with Saccharomyces cerevisiae strains producing heterologous proteins. Most of process development considerations with fed-batch recombinant cultures are linked to the reliability and reproducibility of the process for manufacturing environments where quality assurance and quality control aspects are paramount. In this respect, the quality, safety and efficacy of complex biologically active molecules produced by recombinant techniques are strongly influenced by the genetic background of the host strain, genetic stability of the transformed strain and production process factors. An overview of the recent literature of these culture-related factors is coupled with our experience in yeast fed-batch process development for producing various therapeutic grade proteins. The discussion is based around three principal topics: genetics, microbial physiology and fed-batch process design. It includes the fundamental aspects of yeast strain physiology, the nature of the recombinant product, quality control aspects of the biological product, features of yeast expression vectors, expression and localization of recombinant products in transformed cells and fed-batch process considerations for the industrial production of Saccharomyces cerevisiae recombinant proteins. It is our purpose that this review will provide a comprehensive understanding of the fed-batch recombinant production processes and challenges commonly encountered during process development.
An Economical Operation Analysis Optimization Model For Heavy Equipment Selection (2012)

Optimizing equipment selection in heavy earthwork operations is a critical key in the success of any construction project. The objective of this research incentive was geared towards developing a computer model to assist contractors and construction managers in estimating the cost of heavy earthwork operations. Economical operation analysis was conducted for an equipment fleet taking into consideration the owning and operating costs involved in earthwork operations. The model is being developed in a Microsoft environment and is capable of being integrated with other estimating and optimization models. In this study, Caterpillar® Performance Handbook [5] was the main resource used to obtain specifications of selected equipment. The implementation of the model shall give optimum selection of equipment fleet not only based on cost effectiveness but also in terms of versatility. To validate the model, a case study of an actual dam construction project was selected to quantify its degree of accuracy.
NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation (2013)

N-myc downstream-regulated gene 1 (NDRG1) mutations cause Charcot-Marie-Tooth disease type 4D (CMT4D). However, the cellular function of NDRG1 and how it causes CMT4D are poorly understood. We report that NDRG1 silencing in epithelial cells results in decreased uptake of low-density lipoprotein (LDL) due to reduced LDL receptor (LDLR) abundance at the plasma membrane. This is accompanied by the accumulation of LDLR in enlarged EEA1-positive endosomes that contain numerous intraluminal vesicles and sequester ceramide. Concomitantly, LDLR ubiquitylation is increased but its degradation is reduced and ESCRT (endosomal sorting complex required for transport) proteins are downregulated. Co-depletion of IDOL (inducible degrader of the LDLR), which ubiquitylates the LDLR and promotes its degradation, rescues plasma membrane LDLR levels and LDL uptake. In murine oligodendrocytes, Ndrg1 silencing not only results in reduced LDL uptake but also in downregulation of the oligodendrocyte differentiation factor Olig2. Both phenotypes are rescued by co-silencing of Idol, suggesting that ligand uptake through LDLR family members controls oligodendrocyte differentiation. These findings identify NDRG1 as a novel regulator of multivesicular body formation and endosomal LDLR trafficking. The deficiency of functional NDRG1 in CMT4D might impair lipid processing and differentiation of myelinating cells.
Enhancement of the quantum efficiency and stability of electroluminescence from porous silicon by anodic passivation (1998)

The use of anodic oxidation as a post-treatment of porous silicon has been investigated to enhance the external quantum efficiency of electroluminescence from a device based on a thin transparent indium tin oxide contact on porosified n+-type silicon. Enhancement in external quantum efficiency of three orders of magnitude has been obtained. We report here an external quantum efficiency of 0.21%. The treatment also greatly improves the stability of the device. Results can be explained by the fact that anodic oxidation considerably reduces leakage current flowing via nonconfined silicon.
Next Generation Distributed Computing for Cancer Research (2014)

Advances in next generation sequencing (NGS) and mass spectrometry (MS) technologies have provided many new opportunities and angles for extending the scope of translational cancer research while creating tremendous challenges in data management and analysis. The resulting informatics challenge is invariably not amenable to the use of traditional computing models. Recent advances in scalable computing and associated infrastructure, particularly distributed computing for Big Data, can provide solutions for addressing these challenges. In this review, the next generation of distributed computing technologies that can address these informatics problems is described from the perspective of three key components of a computational platform, namely computing, data storage and management, and networking. A broad overview of scalable computing is provided to set the context for a detailed description of Hadoop, a technology that is being rapidly adopted for large-scale distributed computing. A proof-of-concept Hadoop cluster, set up for performance benchmarking of NGS read alignment, is described as an example of how to work with Hadoop. Finally, Hadoop is compared with a number of other current technologies for distributed computing.
Deep Learning Network on Waveform Components Recognition for Distributed Optic-Fiber Sensing (2021)

We have proposed a deep learning network of SqueezeNet in the application of distributed optic-fiber sensing based on phase-sensitive optical time-domain reflectometry technique. The obtained results show the improvement in the accuracy of waveform components recognition for low SNR and multiple component signals.
Two-Photon Fluorescence Technique to Study Polymer Adsorption at the Toluene−Water Interface (2003)

Adsorption of fluorescein isothiocyanate labeled polystyrene at the toluene−water interface is studied using two-photon fluorescence microscopy. We have developed a protocol to estimate the amount of polymer adsorbed at the interface. The measured surface excess is strongly influenced by fluorescence resonance energy transfer between neighboring fluorescein units. After accounting for this effect, we are able to estimate the surface excess to be approximately 1 mg/m2, which indicates a brushlike conformation for the adsorbed molecules.
Processing of Middle East Crude with Canadian Oil Sands Bitumen-derived Synthetic Crude Oil (2006)

Light (LGO) and heavy or vacuum gas oil (VGO) fractions from mixed Middle East crudes and respective fractions from a typical Canadian oil sands bitumen-derived synthetic crude oil (SCO) were blended at various ratios (up to 40%) and hydrotreated to investigate the kinetics of sulfur and nitrogen removal, and product quality. Hydrotreatment was carried out in down-flow micro reactors over commercially available NiMo/Al2O3 and CoMo/Al2O3 catalysts, varying reactor temperature (350-390°C), pressure (5-10 MPa), and space velocity (1-6 h−1). Blending the LGO with SCO enhanced both sulfur and nitrogen removal from Middle East crude LGOs. Ultra-low sulfur diesel (< 10 wtppm) meeting the Japanese cetane number (CN) specification could be produced under reasonable operating conditions. Engine tests of the hydrotreated LGOs showed that the emissions of CO, HC, NOx, and PM (particulate matters) from a diesel engine were correlated with the fuel CN and aromatics content. Hydrotreatment of blends of VGO and SCO led to lower sulfur content, but higher nitrogen content in the product oils. The estimated yields of FCC gasoline were slightly decreased by blending the SCO but not significantly.
High-Performance Rh2P Electrocatalyst for Efficient Water Splitting (2017)

The search for active, stable, and cost-efficient electrocatalysts for hydrogen production via water splitting could make a substantial impact on energy technologies that do not rely on fossil fuels. Here we report the synthesis of rhodium phosphide electrocatalyst with low metal loading in the form of nanocubes (NCs) dispersed in high-surface-area carbon (Rh<sub>2</sub>P/C) by a facile solvo-thermal approach. The Rh<sub>2</sub>P/C NCs exhibit remarkable performance for hydrogen evolution reaction and oxygen evolution reaction compared to Rh/C and Pt/C catalysts. The atomic structure of the Rh<sub>2</sub>P NCs was directly observed by annular dark-field scanning transmission electron microscopy, which revealed a phosphorus-rich outermost atomic layer. Combined experimental and computational studies suggest that surface phosphorus plays a crucial role in determining the robust catalyst properties.
Topical Vitamin D<sub>3</sub> Downregulates IgE-Mediated Murine Biphasic Cutaneous Reactions (1996)

Hapten-specific and mast-cell-dependent biphasic (immediate and delayed-onset) cutaneous reactions were induced in a murine model by intravenous injection of anti-DNP IgE antibodies followed by a skin test. Four daily applications of topical 1 alpha,24(OH)2D3 ointment significantly inhibited both the immediate and the delayed-onset cutaneous reactions in a dose-dependent fashion, as well as the croton-oil-induced cutaneous reaction and DNFB contact sensitivity reaction. 1 alpha,24(OH)2D3 itself did not show any sensitizing or irritant potential. The inhibitory effect of 1 alpha,24(OH)2D3 on these reactions was limited to the application site and no systemic effect was observed. Another vitamin D3 analog 1 alpha,25(OH)2D3, also showed an inhibitory effect on IgE-mediated cutaneous reactions. These results suggest that topically applied 1 alpha,24(OH)2D3 might modulate IgE-mediated cutaneous reactions and could thus be useful in the treatment of certain human cutaneous disorders other than psoriasis and related keratinizing disorders.
Machine Learning Enables Accurate Prediction of Asparagine Deamidation Probability and Rate (2019)

The spontaneous conversion of asparagine residues to aspartic acid or iso-aspartic acid, via deamidation, is a major pathway of protein degradation and is often seriously disruptive to biological systems. Deamidation has been shown to negatively affect both <i>in vitro</i> stability and <i>in vivo</i> biological function of diverse classes of proteins. During protein therapeutics development, deamidation liabilities that are overlooked necessitate expensive and time-consuming remediation strategies, sometimes leading to termination of the project. In this paper, we apply machine learning to a large (n = 776) liquid chromatography-tandem mass spectrometry (LC-MS/MS) dataset of monoclonal antibody peptides to create computational models for the post-translational modification asparagine deamidation, using the random decision forest method. We show that our categorical model predicts antibody deamidation with nearly 5% increased accuracy and 0.2 MCC over the best currently available models. Surprisingly, our model also paces or outperforms advanced and conventional models on an independent non-antibody dataset. In addition to deamidation probability, we are able to accurately predict deamidation rate (R<sup>2</sup> = 0.963 and Q2 = 0.822), a capability with no peer in current models. This method should enable significant improvement in protein candidate selection, especially in biopharmaceutical development, and can be applied with similar accuracy to enzymes, monoclonal antibodies, next-generation formats, vaccine component antigens, and gene therapy vectors such as adeno-associated virus.
Combined Heat Shield and Solar Thermal Propulsion System for an Oberth Maneuver (2023)

As humanity continues its exploration of space, many space missions are enabled by increases in speed. Examples include outer planet and dwarf planet exploration missions and missions that travel through our solar system into interstellar space. For many of these applications speeds of >10 astronomical units per year (AU/yr) are desired. A powered gravity assist around the Sun may offer the best option for reaching this goal; however, current heat shields and kick stages are too heavy or generate too little thrust. Solar thermal propulsion overcomes this tradeoff by converting the heat of the Sun into thrust. By tripling the specific impulse relative to chemical propulsion and by enabling a smaller perihelion through active cooling, this approach nearly doubles the escape velocity. Our team has designed and built working solar thermal propulsion prototypes out of materials that can survive 2700 K at a 30 x 30 cm scale. These benchtop-scale demonstrations have thus far validated the simplifying assumptions that underlie our thermal and propulsion models. Despite growing confidence that a full-scale heat shield/heat exchanger can survive an Oberth maneuver, many questions remain regarding the feasibility of long-term cryogenic storage of hydrogen propellant.
Brief Discussion on the Security Leaks of VBScript (2003)

By means of the script language VBScript embedded in HTML documents,the dynamic Web pages can be created through using clients' ability to compute.This paper analyses the existing security leaks when VBScript is using clients' ability to compute,and puts forward some corresponding policies.
B cell development and immunoglobulin transcription in Oct-1-deficient mice (2004)

The POU domain transcription factors Oct-1 and Oct-2 interact with the octamer element, a motif conserved within Ig promoters and enhancers, and mediate transcription from the Ig loci. Inactivation of Oct-2 by gene targeting results in normal B cell development and Ig transcription. To study the role of Oct-1 in these processes, the lymphoid compartment of RAG-1(-/-) animals was reconstituted with Oct-1-deficient fetal liver hematopoietic cells. Recipient mice develop B cells with levels of surface Ig expression comparable with wild type, although at slightly reduced numbers. These B cells transcribe Ig normally, respond to antigenic stimulation, undergo class switching, and use a normal repertoire of light chain variable segments. However, recipient mice show slight reductions in serum IgM and IgA. Thus, the Oct-1 protein is dispensable for B cell development and Ig transcription.
Qualification Of A Cryogenic Floating Flexible Hose Enabling Safe And Reliable Offshore LNG Transfer For Tandem FLNG Offloading Systems (2014)

Abstract Moving LNG production to an offshore setting certainly presents a serious set of challenges for the offshore oil and gas industry, particularly when it comes to the design and construction of FLNG facilities which need to maintain the utmost levels of safety and give increased flexibility to LNG production while withstanding the effects of winds, waves and currents in the open seas. With the first FLNG plants now in production and twenty other planned FLNG projects worldwide, it is safe to say that over the past few years these challenges have been overcome and these facilities have well and truly demonstrated their economic and technical viability to the industry. But while some challenges have certainly been met, others remain. The environmental conditions of the current FLNG locations are at present quite mild and only require the use of the most straightforward technology for the unloading of the LNG, e.g. marine loading arms. But, with prospective new FLNG locations moving away from these ‘mild’ areas, to sites where sea states, wind and currents can be much more severe, only tandem LNG offloading systems appear to meet the challenges of the application as they improve safety, operability and availability. Since 2009, Trelleborg has been developing floating cryogenic hoses which ensure LNG offshore transfer with minimum BOG generation, combine high flexibility, reliability and long service life, and also meet LNG operator and contractor's offloading requirements related to safety, flowrate capacity and operation availability. Through latest acquisition, this technology has been even further enhanced, with new parameters being put forward for the development of these hoses in order to become a key component in offloading systems for future offshore FLNG projects. This white paper will discuss Trelleborg's 20" ID cryogenic hose development and qualification program and outline why tandem offloading solutions are a viable alternative for the industry – not only limiting downtime, but also improving safety. The paper will present in this case the innovative offshore LNG offloading system using cryogenic floating hoses which has been jointly developed with Saipem since 2009 and about to be qualified according to EN1474 standard requirements.
Levels of Therapeutic Antivenin and Venom in a Human Snakebite Victim (1996)

An enzyme-linked immunosorbent assay was used to measure the levels of therapeutic antivenin (Antivenin [Crotalidae] Polyvalent, Wyeth-Ayerst) in serum and the levels of venom in the urine of a patient bitten by a western diamondback rattlesnake (Crotalus atrox). Serum and urine samples were taken on admission, during hospitalization, and during follow-up until 5 months after the bite. Photographs were taken of the bite site on admission to the hospital and during follow-up. Serum levels of therapeutic antivenin were highest between 1 and 3 days after the bite but were still detectable 46 days as well as 4 months after the bite. Crotalus atrox venom was detectable in the urine 4 days after the bite and was still measurable 6 days after the bite.
Estimating Left Ventricle Ejection Fraction Levels Using Circadian Heart Rate Variability Features and Support Vector Regression Models (2020)

This study paves the way to explore the use of HRV features in the prediction of LVEF percentages as an indicator of disease progression, which may lead to an automated classification process for CAD patients.
beta 1-and beta 2-adrenergic receptors exhibit differing susceptibility to muscarinic accentuated antagonism (1997)

Neonatal rat ventricular myocytes express both beta 1-and beta 2-adrenergic receptors linked to enhanced intracellular adenosine 3',5'-cyclic monophosphate (cAMP) accumulation and the modulation of contractile function. This study tests the hypothesis that muscarinic agonists act via distinct mechanisms to interfere with beta 1-and beta 2-adrenergic receptor actions. The beta 2-selective agonist zinterol (10(-7) M) elicits approximately a fourfold increase in cAMP accumulation, which is mimicked, both in magnitude and kinetics, by 10(-9) M of the mixed beta 1-receptor agonist/beta 2-receptor agonist isoproterenol. At these concentrations, isoproterenol and zinterol elicit equivalent inotropic and lusitropic (i.e., enhanced relaxation) responses. Carbachol inhibits all three responses (cAMP, inotropic, and lusitropic) elicited by isoproterenol. In contrast, carbachol does not interfere with the effect of zinterol to augment cAMP accumulation or to induce a positive inotropic response. However, carbachol inhibits the lusitropic response to zinterol via an action at an M2-muscarinic receptor linked to a pertussis toxin-sensitive pathway. Additional studies indicate that beta 2-receptor-dependent phosphorylation of troponin I and phospholamban is substantially attenuated by carbachol. We conclude that carbachol interferes with beta 1-receptor actions by reducing cAMP accumulation. In contrast, the anti-beta 2-receptor actions of carbachol are mediated by a mechanism that is distinct from inhibition of cAMP accumulation, involving an M2-muscarinic receptor coupled to a pertussis toxin-sensitive G protein, which leads to inhibition of troponin I and phospholamban phosphorylation and inhibition of the beta 2-receptor-dependent lusitropic response.
N-Terminal addition of glycine to amino acid and peptide esters activated by the cobalt(III)ion (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN-Terminal addition of glycine to amino acid and peptide esters activated by the cobalt(III)ionDavid A. Buckingham, Luigi G. Marzilli, and Alan M. SargesonCite this: J. Am. Chem. Soc. 1967, 89, 17, 4539–4540Publication Date (Print):August 1, 1967Publication History Published online1 May 2002Published inissue 1 August 1967https://pubs.acs.org/doi/10.1021/ja00993a061https://doi.org/10.1021/ja00993a061research-articleACS PublicationsRequest reuse permissionsArticle Views115Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts