gebhart/patrepeval huggingface dataset:
A UVB-responsive common variant at chr7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor gene ( AHR ) (2021)

Abstract Genome-wide association studies have identified a melanoma-associated locus on chromosome band 7p21.1 with rs117132860 as the lead SNP, and a secondary independent signal marked by rs73069846. rs117132860 is also associated with tanning ability and cutaneous squamous cell carcinoma (cSCC). As ultraviolet radiation (UVR) is a key environmental exposure for all three traits, we investigated the mechanisms by which this locus contributes to melanoma risk, focusing on cellular response to UVR. Fine-mapping of melanoma GWAS identified four independent sets of candidate causal variants. A GWAS region-focused Capture-C study of primary melanocytes identified physical interactions between two causal sets and the promoter of the aryl hydrocarbon receptor gene ( AHR ). Subsequent chromatin state annotation, eQTL, and luciferase assays identified rs117132860 as a functional variant and reinforced AHR as a likely causal gene. As AHR plays critical roles in cellular response to dioxin and UVR, we explored links between this SNP and AHR expression after both 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and ultraviolet B (UVB) exposure. Allele-specific AHR binding to rs117132860-G was enhanced following both, consistent with predicted weakened AHR binding to the risk/poor-tanning rs117132860-A allele, and allele-preferential AHR expression driven from the protective rs117132860-G allele was observed following UVB exposure. Small deletions surrounding rs117132860 via CRISPR abrogates AHR binding, reduces melanocyte cell growth, and prolongs growth arrest following UVB exposure. These data suggest AHR is a melanoma susceptibility gene at the 7p21.1 risk locus, and rs117132860 is a functional variant within a UVB-responsive element, leading to allelic AHR expression, and altering melanocyte growth phenotypes upon exposure.
Refractive index of ternary liquid systems of squalane (+ hexane + benzene; + cyclohexane + benzene and + hexane + cyclohexane) (2005)

Refractive indices, n D at 298.15, 303.15, 308.15 and 313.15K and densities at 298.15 K have been measured for the ternary mixtures of squalane with hexane + benzene; cyclohexane + benzene, and hexane + cyclohexane over the complete mole fraction range. The validity of the refractive index mixing rules of Lorentz-Lorenz, Gladstone-Dale, Arago-Biot, Wiener and Heller has been tested for the three ternary liquid systems. Relative merits of these mixing rules have been presented and results are analysed in terms of average percentage deviations (APD).
Novel 3D high‐resolution manometry metrics for quantifying esophagogastric junction contractility (2017)

We devised novel 3D-HRM metrics to quantify the CD (3D-DH<sub>A</sub> ) and LES (3D-LESP) elements of EGJ contractility. Both measures correlated strongly with conventional HRM metrics of EGJ contractility. The 3D-DH<sub>A</sub> , in particular, correlated strongly with the EGJ-CI suggesting that both are largely determined by CD contractility. It is hoped that future studies will show these new metrics useful in quantifying elements of the antireflux barrier in mechanistically defined subsets of gastro-esophageal reflux disease (GERD) patients.
Functional Nano-Coating Materials by Michael Addition and Ring-opening Polymerization: Reactivity, Molecular Architecture and Refractive index (2018)

Understanding the molecular interaction and morphology of organic-inorganic hybrid materials is an important and fundamental assignment to develop novel high-performance materials. In this work, we developed two types of hybrid coating materials by using different silane coupling agents via Michael addition reaction and ring-opening polymerization. The changes in molecular interaction and morphology of the hybrid coatings due to chemical composition and curing temperature were studied by electron microscopy, spectroscopy and solid state <sup>29</sup>Si nuclear magnetic resonance analysis. Fundamental differences were observed in HYBRID I and HYBRID II coatings during the nucleation stage that was dependent on the curing temperature. Higher curing temperature of the hybrid coatings resulted in improved uniformity and greater crystallinity of dispersed phases, and better control of the morphology compared with coatings cured at lower temperatures. The higher curing temperature provided more consistent nucleation sites for the growth of larger nanostructures of desired characteristics (e.g., size and surface features). There is great flexibility in synthesizingg these hybrid materials where different structure and morphology can be achieved to produce materials whose applications can range from adhesives to protective coatings. Refractive index results revealed that HYBRID I (90 °C) coating showed higher refractive index than HYBRID II (90 °C) coating.
Effect of Acid Treatment of Plant Cuticles on Sorption of Selected Auxins (1987)

Sorption characteristics of 2-(1-naphthyl)acetic acid (NAA), 2-(1-naphthyl)acetamide (NAAm), and 2,4-dichlorophenoxyacetic acid (2,4-D) were determined for cuticles enzymically isolated from mature tomato (Lycopersicon esculentum Mill. cv Sprinter) and pepper (Capsicum annuum L.) fruit. Sorption equilibrium for NAA and 2,4-D by tomato cuticular membranes (CM) and dewaxed cuticular membranes (DCM) was achieved within 24 hours at 25 degrees C. The average K (partition coefficient) values for NAA in tomato CM and DCM were 166 and 204, respectively, whereas the corresponding K values for 2,4-D were 292 and 383, respectively. Sorption equilibrium for 2,4-D and NAA in pepper cuticles was not achieved after 18 and 63 days, respectively. Sorption equilibrium for NAAm in tomato and pepper CM and DCM was attained within 48 hours. Acid pretreatment (2.0 n HCl, 10 minutes) had no effect on NAA, 2,4-D, or NAAm sorption by tomato CM and DCM, or on NAAm sorption by pepper CM and DCM. Acid pretreatment of pepper CM and DCM led to slightly lower K(pH) (apparent partition coefficient) values for both NAA and 2,4-D. More significantly, sorption equilibrium for NAA and 2,4-D in pepper CM and DCM was achieved within 24 hours after acid treatment.
Internet of Things: Recent advances and applications (2013)

Summary form only given. About 200 years ago, Industrial Revolution, in which muscle power from both human and animals was replaced by mechanical power, accelerated productivity and economic growth sharply. Started in 1950, Internet Revolution that relied on computing, communication and networking technologies increased productivity and propelled the global economy even more sharply than Industrial Revolution did. What is the next “revolution” that will bring a new wave of productivity gain? Our answer is “Internet of Things (IoT)” also called “Industrial Internet”. It consists of intelligent devices, intelligent systems, and intelligent decisioning that allow the physical world of machines, facility, fleets and networks to more deeply merge with the connectivity, big data and analytics of the digital world. With IoT, all things in the world link and communicate with each other. They have their identities, physical attributes, and interfaces. They are seamlessly integrated into the information network such that they become active participants in business, information and social processes wherever and whenever needed and proper. They can interact among themselves and with the environment by exchanging data and information `sensed' about the environment, while reacting autonomously to the events by triggering actions and creating services with or without direct human intervention. What are the proper architectures for such IoT? How can one implement them? What are the technical challenges? What are the existing applications showing the promise of IoT? This talk intends to answer these questions and lead the audience to an exciting field of IoT and their various applications including environmental monitoring, intelligent transportation systems and smart grids.
Abstract 123: Erythropoietin Enhances Abundance of Cardiomyogenic Precursors in vitro and in vivo (2013)

Recent data suggest that erythropoietin (Epo) can improve cardiac function following ischemia reperfusion injury. We found EpoR to be prominently expressed in embryonic rather than adult mouse heart. In the latter EpoR expression was confined to interstitial cells. We isolated the non-myocyte fraction of adult mouse hearts by enzymatic digestion and straining (pore size: 30 µm) and found a 4-fold higher EpoR expression compared to unselected cardiac cells (n=3). Flow cytometry (FC) revealed that 24±3% of this heterogeneous cell pool expressed EpoR (n=3) and 11±2% co-expressed αMHC. Half of the αMHC+ cells stained positive for Ki67, consistent with FC showing that 49±7% αMHC+/EpoR+ cells were in S and G2 phase (n=3; vs. 13±3% in αMHC-/EpoR-; n=3). Interestingly, co-culture with neonatal rat cardiomyocytes yielded EGFP+ cardiomyocyte-like cells. Since αMHC+ proliferated and differentiated in vitro we termed them cardiomyogenic precursors (CMPs). Epo treatment of the non-myocyte pool enhanced Akt phosphorylation (n=6/group) and increased CMP abundance in vitro (2-fold; n=3). Cell cycle arrest abrogated the aforementioned effect, suggesting that Epo influenced CMP proliferation. Finally, we tested the potential of Epo to protect against ischemia by enhancing CMP numbers in a model of myocardial infarction (MI). Following MI mice were treated twice with 2,000 U/kg Epo (i.p.). Ten weeks post MI echocardiography revealed blunted myocardial deterioration in mice receiving Epo (ΔEF=-11.18%, n=5) compared to control (ΔEF=-20.82%, n=6). FC revealed an enhanced αMHC+/cTnT+ cell pool in the Epo treated group (20.3±1.9% vs. 10.6±2.3% in control, n=8/6) 4 weeks post MI. In conclusion, we found that EpoR is expressed in a putative cardiomyogenic precursor cell pool in the adult heart. CMPs appear to proliferate in vitro and in vivo; with further enhanced proliferation under Epo administration. This may contribute to Epo mediated protection after MI and highlights the therapeutic effect of Epo upon ischemic cardiac injury. Whether these cells remain from embryogenesis or just constitute an immature myocyte population in the adult heart deriving from cardiomyocyte dedifferentiation needs to be further investigated.
Annealing of degraded npn-transistors-mechanisms and modeling (1994)

We report on the annealing of degraded npn-transistors, which includes a new model describing the decrease of base current during annealing. We found that two mechanisms are responsible for annealing: the recombination of charges and the bonding of hydrogen atoms on interface traps. Furthermore, we show that a heating of the whole device and a forward biasing of the emitter-base-diode activate these annealing mechanisms. This biasing deactivates the interface traps by recombination with a part of the streaming charge and results in a local increase in temperature, caused by the current. Both local and global heating yield an additional thermal generation of charges and an increasing diffusivity of hydrogen atoms. Consequently, an additional deactivation and passivation of interface traps is detected.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Stability of Garnet-Type Lithium-Ion Conducting Solid Electrolyte Li7La3Zr2O12 in Aqueous Electrolytes (2010)

Abstract not Available.
Improvement of Dissolution Property of Poorly Water-Soluble Drug by Novel Dry Coating Method Using Planetary Ball Mill (2008)

The dissolution property of a poorly water-soluble drug, flurbiprofen (FP), was improved by a novel dry coating method using a planetary ball mill. Several mixtures composed of water-soluble additives (D-mannitol, lactose, and erythritol), light anhydrous silicic acid, and flurbiprofen were prepared. These mixtures and several starches were co-ground in a planetary ball mill, and the surface of the starches was dry coated with the mixtures. The size, appearance, yield, and drug dissolution property of the dry coated preparations were evaluated, and the optimal formulation which improved the dissolution property of poorly water-soluble flurbiprofen was determined. The dissolution rate of FP was increased by dry coating of the surface of starches with microparticulated FP. It was further increased by co-grinding of FP, starch, and a water-soluble additive, or dry coating of the starch surface with microparticulated FP and light anhydrous silicic acid, as a glidant. These co-ground and dry coated preparations could be recovered from the pot of the planetary ball mill readily without adhesion to the inside wall of the pot. These are considered to be novel, industrially applicable methods for improving the dissolution rate of poorly water-soluble drugs.
Structural and transcriptional characterization of the external spacer of a ribosonal RNA nuclear gene from a higher plant (1988)

International audience
Supplementary Tables legend from Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases (2023)

&lt;p&gt;Legend for Supplementary Tables:1,2,3,4&lt;/p&gt;
Surface charging analysis of high-inclination, high-altitude spacecraft: Identification and physics of the plasma source region (1993)

Surface charging has been identified as the probable cause of anomalies experienced by several high-inclination, high-altitude spacecraft. These spacecrafts have no monitors of the local space particle environment. Thus, a direct association of anomaly occurrence with surface discharge is not possible. The authors use empirical magnetic-field models to map from a satellite's position, at the time of an anomaly, to the Earth's magnetospheric equatorial plane. They appeal to the well-established occurrence distribution of spacecraft charging in the near-geostationary orbit equatorial plane as a function of magnetic local time, radial distance, and geomagnetic activity to interpret the anomaly events. On the basis of the similarity between known surface charging distributions and the anomaly distributions, it is concluded that anomaly-associated surface charging likely occurred owing to transient hot plasma and medium-energy electrons associated with magnetospheric substorms. It is believed that this technique will aid satellite operators in the assessment of anomalies experience by high-inclination spacecraft.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Ingestion of BioCell Collagen&reg;, a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs (2012)

Skin aging and its clinical manifestation is associated with altered molecular metabolism in the extracellular matrix of the dermis. In a pilot open-label study, we investigated the effect of a dietary supplement, BioCell Collagen(®) (BCC), which contains a naturally occurring matrix of hydrolyzed collagen type II and low-molecular-weight hyaluronic acid and chondroitin sulfate, in 26 healthy females who displayed visible signs of natural and photoaging in the face. Daily supplementation with 1 g of BCC for 12 weeks led to a significant reduction of skin dryness/scaling (76%, P = 0.002) and global lines/wrinkles (13.2%, P = 0.028) as measured by visual/tactile score. Additionally, a significant increase in the content of hemoglobin (17.7%, P = 0.018) and collagen (6.3%, P = 0.002) in the skin dermis was observed after 6 weeks of supplementation. At the end of the study, the increase in hemoglobin remained significant (15%, P = 0.008), while the increase in collagen content was maintained, but the difference from baseline was not significant (3.5%, P = 0.134). This study provides preliminary data suggesting that dietary supplementation with BCC elicits several physiological events which can be harnessed to counteract natural photoaging processes to reduce visible aging signs in the human face. A controlled study is necessary to verify these observations.
An RNA Alternative to Human Transferrin: A New Tool for Targeting Human Cells (2012)

The transferrin receptor, CD71, is an attractive target for drug development because of its high expression on a number of cancer cell lines and the blood brain barrier. To generate serum-stabilized aptamers that recognize the human transferrin receptor, we have modified the traditional aptamer selection protocol by employing a functional selection step that enriches for RNA molecules which bind the target receptor and are internalized by cells. Selected aptamers were specific for the human receptor, rapidly endocytosed by cells and shared a common core structure. A minimized variant was found to compete with the natural ligand, transferrin, for receptor binding and cell uptake, but performed ~twofold better than it in competition experiments. Using this molecule, we generated aptamer-targeted siRNA-laden liposomes. Aptamer targeting enhanced both uptake and target gene knockdown in cells grown in culture when compared to nonmodified or nontargeted liposomes. The aptamer should prove useful as a surrogate for transferrin in many applications including cell imaging and targeted drug delivery.
Effectiveness of high‐dose riboflavin in migraine prophylaxis A randomized controlled trial (1998)

A deficit of mitochondrial energy metabolism may play a role in migraine pathogenesis. We found in a previous open study that high-dose riboflavin was effective in migraine prophylaxis. We now compared riboflavin (400 mg) and placebo in 55 patients with migraine in a randomized trial of 3 months duration. Using an intention-to-treat analysis, riboflavin was superior to placebo in reducing attack frequency (p = 0.005) and headache days (p = 0.012). Regarding the latter, the proportion of patients who improved by at least 50%, i.e. "responders," was 15% for placebo and 59% for riboflavin (p = 0.002) and the number-needed-to-treat for effectiveness was 2.3. Three minor adverse events occurred, two in the riboflavin group (diarrhea and polyuria) and one in the placebo group (abdominal cramps). None was serious. Because of its high efficacy, excellent tolerability, and low cost, riboflavin is an interesting option for migraine prophylaxis and a candidate for a comparative trial with an established prophylactic drug.
Determination of Free Sulfur in Lubricating Oil (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Free Sulfur in Lubricating OilHarry Levin and Ervin StehrCite this: Ind. Eng. Chem. Anal. Ed. 1942, 14, 2, 107–109Publication Date (Print):February 1, 1942Publication History Published online1 May 2002Published inissue 1 February 1942https://pubs.acs.org/doi/10.1021/i560102a003https://doi.org/10.1021/i560102a003research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Effect of Initiative Additives on Hydro-Thermal Cracking of Heavy Oils and Model Compound (2003)

The hydro-thermal cracking of heavy oils, such as Canadian oil sand bitumen and Arabian heavy vacuum residue, as well as their model compound, was performed over sulfided Ni/Al2O3 and NiMo/Al2O3 catalysts under 663−703 K and 5.0−8.0 MPa of hydrogen pressure in a batch autoclave reactor. According to the reaction mechanism of hydro-thermal cracking, some free radical initiators, such as di-tert-butyl-peroxide (DTBP), sulfur, etc., were added into the feed to generate free radicals at lower temperature, and some initiators did obviously show a promotional effect on the conversion of hydrocarbons. The reaction mechanisms of hydro-thermal cracking as well as the enhancing effect of initiators were studied by a probe reaction with 1-phenyldodecane as a model compound under the conditions of hydro-thermal cracking. The hydro-thermal cracking of hydrocarbons proceeded via a free-radical mechanism and hydrogenating quench. The initiators might easily generate free radicals under the reaction temperature, these radicals might abstract H from hydrocarbon molecules and reasonably initiated the chain reactions, therefore, promoted the conversion of hydrocarbons even at lower reaction temperature. The reaction temperature could be lowered by the addition of a free radical initiator, while keeping the same conversion level.
Effect of long-term physical exercise on lymphocyte reactivity: similarity to spaceflight reactions. (1988)

The response of critical immunological parameters in seven athletes to the sustained physical stress of marathon running was assessed. Variables analysed were the responsiveness of lymphocytes (measured as mitogenic response to concanavalin A), the numbers of lymphocytes, their subsets, and leukocyte numbers. In addition, blood levels of cortisol, epinephrine, and norepinephrine were determined. After the run, lymphocyte responsiveness was severely depressed to 1-70% of the resting values, even though the lymphocyte counts did not change. Leukocyte counts were elevated 2.8-fold. No dramatic changes were found within the lymphocyte subsets, although an increase in pan T-cells and the helper/inducer subset 2 d after the run was significant. In addition, the numbers of B-cells decreased significantly. No change was observed within the suppressor/cytotoxic subset. Cortisol increased 2.1-fold, epinephrine 3.2-fold and norepinephrine 2.7-fold. All these parameters returned to baseline values within 2 d. These data were compared with data obtained during and after spaceflight. We conclude that prolonged physical stress of marathon running induces changes in immunological responsiveness that are strikingly similar to those arising from the stress of spaceflight.
Combined Statin and Niacin Therapy Remodels the High-Density Lipoprotein Proteome (2008)

Combined statin and niacin therapy partially reverses the changes in the protein composition seen in HDL(3) in coronary artery disease subjects. Our observations raise the possibility that quantifying the HDL proteome could provide insights into the therapeutic efficacy of antiatherosclerotic interventions.
Where Do Batteries End and Supercapacitors Begin? (2014)

Electrochemical measurements can distinguish between different types of energy storage materials and their underlying mechanisms.