gebhart/patrepeval huggingface dataset:
Imaging Tolerance Induction in the Classic Medawar Neonatal Mouse Model: Active Roles of Multiple F1-Donor Cell Types (2015)

The immature immune system is uniquely susceptible to tolerance induction and thus an attractive target for immunomodulation strategies for organ transplantation. Newborn mice injected with adult semi-allogeneic lymphohematopoietic cells accept transplants without immunosuppressive drugs. Early in vivo/in situ events leading to neonatal tolerance remain poorly understood. Here, we show by whole body/organ imaging that injected cells home to lymphoid organs and liver where various F1-donor cell types selectively alter neonatal immunity. In host thymus, F1-donor dendritic cells (DC) interact with developing thymocytes and regulatory T cells suggesting a role in negative selection. In spleen and lymph nodes, F1-donor regulatory T/B cells associate with host alloreactive cells and by themselves prolong cardiac allograft survival. In liver, F1-donor cells give rise to albumin-containing hepatocyte-like cells. The neonatal immune system is lymphopenic, Th-2 immunodeviated and contains immature DC, suggesting susceptibility to regulation by adult F1-donor cells. CD8a T cell inactivation greatly enhances chimerism, suggesting that variable emerging neonatal alloreactivity becomes a barrier to tolerance induction. This comprehensive qualitative imaging study systematically shows contribution of multiple in vivo processes leading simultaneously to robust tolerance. These insights into robust tolerance induction have important implications for development of strategies for clinical application.
A Novel Approach for the Inspection of Flexible Parts Without the Use of Special Fixtures (2011)

In a free state, flexible parts may have different shapes compared to their computer-aided design (CAD) model. Such parts may likewise undergo large deformations depending on their space orientation. These conditions severely restrict the feasibility of inspecting flexible parts without restricting the deformations of the part and therefore require dedicated and expensive tools such as a conformation jig or a fixture to maintain the integrity of the part. To address these challenges, this paper proposes a new inspection method, the iterative displacement inspection (IDI) algorithm, that evaluates profile variations without the need for specialized fixtures. This study examines 32 models of simulated manufactured parts to show that the IDI algorithm can iteratively deform the meshed CAD model until it resembles the scanned manufactured part, which enables their comparison. The method deforms the mesh in such a manner so as to ensure its smoothness. This way, neither surface defects nor the measurement noise of the scanned parts are concealed during the matching process. As a result, the case studies illustrate that the method’s error essentially only represents the scanned part’s measurement noise. The inspection results, therefore, solely reflect the effect of variations from the manufacturing process itself and not the deformation of the part.
Structuring and visualising the WWW by generalised similarity analysis (1997)

This paper describes a generic approach to structuring and visualising a hypertext-based information space on the WWW. This approach, called Generalised Similarity Analysis (GSA), provides a unifying framework for extracting structural patterns from a range of proximity data concerning three fundamental relationships in hypertext, namely, hypertext linkage, content similarity and browsing patterns. GSA emphasizes the integral role of users’ interests in dynamically structuring the underlying information space. Pathfinder networks are used as a natural vehicle for structuring and visualising the rich structure of an information space by highlighting salient relationships in proximity data. In this paper, we use the GSA framework in the study of hypertext documents automatically retrieved over the Internet, including a number of departmental WWW sites and conference proceedings on the WWW. We show that GSA has several distinct features for structuring and visualising hypertext information spaces. GSA provides some generic tools for developing adaptive user interfaces to hypertext systems. Link structures derived by GSA can be used together with dynamic linking mechanisms to produce a number of hypertext versions of a common information space.
Structure and properties of polyurethane-silica nanocomposites (2000)

Nanocomposites with different concentrations of nanofiller were prepared by adding nanosilica filler to the single-phase polyurethane matrix. A control series was prepared with the same concentrations of micron-size silica. The nanosilica filler was amorphous, giving composites with the polyurethane that were transparent at all concentrations. The nanocomposites displayed higher strength and elongation at break but lower density, modulus, and hardness than the corresponding micron-size silica-filled polyurethanes. Although the nanosilica showed a stronger interaction with the matrix, there were no dramatic differences in the dielectric behavior between the two series of composites. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 76: 133–151, 2000
Participant and Parent Experiences in the Parenteral Insulin Arm of the Diabetes Prevention Trial for Type 1 Diabetes (2007)

Overall, most participants were positive about the trial, and many expressed optimism about the intervention's potential for success. These results have implications for study design, recruitment, and retention procedures in future prevention trials.
LPA1‐induced migration requires nonmuscle myosin II light chain phosphorylation in breast cancer cells (2011)

The enhanced migration found in tumor cells is often caused by external stimuli and the sequential participation of cytoskeleton-related signaling molecules. However, until now, the molecular connection between the lysophosphatidic acid (LPA) receptor and nonmuscle myosin II (NM II) has not been analyzed in detail for LPA-induced migration. Here, we demonstrate that LPA induces migration by activating the LPA(1) receptor which promotes phosphorylation of the 20 kDa NM II light chain through activation of Rho kinase (ROCK). We show that LPA-induced migration is insensitive to pertussis toxin (PTX) but does require the LPA(1) receptor as determined by siRNA and receptor antagonists. LPA activates ROCK and also increases GTP-bound RhoA activity, concomitant with the enhanced membrane recruitment of RhoA. LPA-induced migration and invasion are attenuated by specific inhibitors including C3 cell-permeable transferase and Y-27632. We demonstrate that NM II plays an important role in LPA-induced migration and invasion by inhibiting its cellular function with blebbistatin and shRNA lentivirus directed against NM II-A or II-B. Inhibition or loss of either NM II-A or NM II-B in 4T1 cells results in a decrease in migration and invasion. Restoration of the expression of NM II-A or NM II-B also rescued LPA-induced migration. Taken together, these results suggest defined pathways for signaling through the LPA(1) receptor to promote LPA-mediated NM II activation and subsequent cell migration in 4T1 breast cancer cells.
Differences in emergency endoscopy outcomes according to gastrointestinal bleeding location (2020)

The clinical course was significantly worse in patients with UGIB than in patients with LGIB. The influence of emergency endoscopy differed according to GI bleeding location.
Racial Differences in Glycemic Markers: A Cross-sectional Analysis of Community-Based Data (2011)

National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.
Conformational analysis by NMR and distance geometry techniques of a peptide mimetic of the third helix of the Antennapedia homeodomain* (2005)

The Antennapedia homeodomain structure consists of four helices. The helices II and III are connected by a tripeptide that forms a turn, and constitute the well-known helix-turn-helix motif. The recognition helix penetrates the DNA major groove, gives specific protein-DNA contacts and forms direct, or water-mediated, intermolecular hydrogen bonds. It was suggested that helix III (and perhaps also helix IV) might represent the recognition helix of Antennapedia homeodomain, which makes contact with the surface of the major groove of the DNA. In an attempt to clarify the helix III capabilities of assuming an helical conformation when separated from the rest of the protein, we carried out the structural determination of the recognition helix III in different solvent media. The conformational study of fragments 42-53, where residues W48 and F49, not involved in the protein-DNA interaction, were substituted by two alanines, was conducted in sodium dodecyl sulfate (SDS), trifluoroethanol (TFE) and TFE/water, using circular dichroism, nuclear magnetic resonance (NMR) and distance geometry (DG) techniques. The fragment assumes a well-defined secondary structure in TFE and in TFE/water (90/10, v/v) with an alpha-helix encompassing residues 4-9, while in TFE/water (70/30, v/v) a less regular structure was found. The DG results in the micellar system evidence the presence of a distorted alpha-helical conformation involving residues 4-8. Our results reveal that the isolated Antennapedia recognition helix III tend to preserve in solution the alpha-helical conformation even if separated from the rest of the molecule.
Minimal incision techniques for digital deformities. (1986)

We have presented basic minimal incision approaches to the more common digital deformities. We feel that with proper evaluation of the deformity and the patient, minimal incision surgery techniques give excellent long-term results with several advantages. These advantages include: Less discomfort due to less surgical dissection. Less need for internal fixation by careful use of compression dressings in the immediate postoperative period along with early ambulation. Less disability. Compression dressings allow immediate ambulation in normal footgear. In most instances, the patient is able to return to work sooner and with less discomfort. Better patient acceptance. Procedures may be performed under local anesthesia in the office environment and the patient may usually return to work in normal footgear within 1 to 3 days. Cost containment. Not all digital deformities may be addressed through a minimal incision approach. Internal fixation, multiple procedures with special postoperative shoes, syndactylisms, fusions, transpositional osteotomies, and skin plasties may be necessary in more severe conditions. However, it is equally important to point out that not all digital deformities must be approached in the "traditional" manner, employing large incisions with deep structure dissection, retraction, and visualization. It is up to the podiatric surgeon to develop his skills, and, after carefully evaluating the abnormality, the patient, and his goals, to perform the surgical procedure that will result in the best long-term results with the minimal amount of discomfort, disability, and cost to the patient.
Welcome to the 2017 IEEE radar conference (2017)

On behalf of the IEEE Aerospace and Electronics Society, the Seattle Section and AES Chapter, our technical co-sponsors and the Organizing Committee I welcome everyone to the 2017 IEEE Radar Conference, RadarConf '17. We are proud to continue the annual conference tradition dating back to 1984. Our quest for excellence in the science, engineering, and yes, art, of radar systems, signal processing and remote sensing is enhanced by the breadth of international participation. Acclaimed experts, authors, tutorial instructors, delegates, Corporate Supporters and exhibitors from 32 countries will participate. Continuing the Women in Engineering Program, we assembled a panel of truly accomplished individuals with views from science, industry and academia. In addition, we are especially pleased, enabled by the excellent corporate support and IEEE AES and National Science Foundation grants, to have provided travel grants to students from all over the world to facilitate their attendance and the beginnings of their careers in radar.
Laser pulse shaping for generating uniform three-dimensional ellipsoidal electron beams (2009)

A scheme of generating a uniform ellipsoidal laser pulse for high-brightness photoinjectors is discussed. The scheme is based on the chromatic aberration of a dispersive lens. Fourier optics simulation reveals the interplay of group velocity delay and dispersion in the scheme, as well as diffractions. Particle tracking simulation shows that the beam generated by such a laser pulse approaches the performance of that by an ideal ellipsoidal laser pulse and represents a significant improvement from the traditionally proposed cylindrical beam geometry. The scheme is tested in an 800-nm, optical proof-of-principle experiment at lower peak power with excellent agreement between the measurement and simulation.
Editor's Note (2012)

The articles by Dr. Yoshitaka Fujii in Table 1 are hereby retracted. The retraction notices are published in this issue.Table 1: Retracted ArticlesThe retraction notices are being issued as a result of: overwhelming evidence of fabrication, related to the fact that the distributions of many variables reported by Dr Fujii in these studies could not have occurred by chance,1,2 the inability of Dr Fujii's institutions to attest to the integrity of the study and/or its data conducted under their auspices, as set out in the Joint Editors-in-Chief Request for Determination of April 9, 2012.* The articles by Dr. Fujii in Table 2 are under review by the University of Tsukuba. These articles are considered compromised until assessed by the University of Tsukuba. Articles in Table 2 not affirmed as valid by the University of Tsukuba will be retracted. The University of Tsukuba has affirmed the validity of an article by Dr. Uemura3 for which Dr. Fujii was a coauthor. This article remains part of the unimpeached medical literature. The response from each institution, as well as an analysis of Dr. Fujii's published research by the Japanese Society of Anesthesiologists, is available online.†Table 2: Compromised Articles Under Review at the University of TsukubaKobe University was mistakenly listed as one of the responsible institutions in the initial Joint Editors-in-Chief Request for Determination Regarding Papers Published by Dr. Yoshitaka Fujii. Kobe University has never been associated with Dr. Fujii. Steven L. Shafer, MD Editor-in-Chief Anesthesia & Analgesia
The Activation of Specific Bonds in Complex Molecules at Catalytic Surfaces. I. The Carbon—Hydrogen Bond in Methane and Methane-d4 (1936)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Activation of Specific Bonds in Complex Molecules at Catalytic Surfaces. I. The Carbon—Hydrogen Bond in Methane and Methane-d4Kiyoshi Morikawa, W. S. Benedict, and Hugh S. TaylorCite this: J. Am. Chem. Soc. 1936, 58, 8, 1445–1449Publication Date (Print):August 1, 1936Publication History Published online1 May 2002Published inissue 1 August 1936https://pubs.acs.org/doi/10.1021/ja01299a040https://doi.org/10.1021/ja01299a040research-articleACS PublicationsRequest reuse permissionsArticle Views171Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A novel algorithmic method for piezoresistance calculation (2014)

A novel algorithmic method, based on the different stress distribution on the surface of thin film in an SOI microstructure, is put forward to calculate the value of the silicon piezoresistance on the sensitive film. In the proposed method, we take the Ritz method as an initial theoretical model to calculate the rate of piezoresistance ΔR/R through an integral (the closed area Ω where the surface piezoresistance of the film lies as the integral area and the product of stress σ and piezoresistive coefficient π as the integral object) and compare the theoretical values with the experimental results. Compared with the traditional method, this novel calculation method is more accurate when applied to calculating the value of the silicon piezoresistance on the sensitive film of an SOI pieoresistive pressure sensor.
Study of Unforced and Modulated Film-Cooling Jets Using Proper Orthogonal Decomposition—Part I: Unforced Jets (2012)

The effects of jet flow-rate modulation were investigated in the case of a 35 deg inclined jet in cross-flow over a flat plate using Mie scattering visualizations, time-resolved flow rate records, and large eddy simulations (LES). An unforced jet study was conducted over a wide range of blowing ratios to provide a baseline for comparison to the pulsed results. The two distinct and well known steady jet regimes (attached jet with high film cooling performance for BR &lt; 0.4 and detached jet with poor film cooling performance for BR &gt; 1.0) were related to the dynamics of characteristic vortical structures, significant in the transition from one regime to the other. Similarity of the inclined jet results with a past vertical jet study are also put in perspective when comparing wall adiabatic effectiveness results. 3D proper orthogonal decomposition (3D-POD) was performed on LES results of an unforced case at BR = 0.15 to provide an analysis of dominant modes in the velocity and temperature fields. Error calculations on the reconstructed fields provided an estimation of the number of modes necessary to obtain satisfactory reconstruction while revealing some of the shortcomings associated with POD.
Echo-Rich and Echo-Poor Periportal Cuffing: Pole Position for Inflammatory Bowel Diseases (2008)

Periportal cuffing of the liver is an extremely rare ultrasonographic phenomenon with a prevalence of approximately 0.95 % in our unit. Echo-rich periportal cuffing occurs more frequently than echo-poor periportal cuffing. The majority of echo-poor periportal cuffing is associated with malignant disorders, in particular haematological diseases, whereas echo-rich periportal cuffing is most frequently seen in inflammatory bowel disease patients.
The role of geminate reaction in the self‐sensitized photooxygenation of helianthrene and hetianthrene‐derivatives encounter‐ and reencounter probabilities (1987)

Abstract The probabilities p exp RQ of the geminate reaction between singlet oxygen ( 1 Δ) and helianthrene (H), mesodiphenylhelianthrene (MDH) and mesodiphenylbenzhelianthrene (MDBH) were determined in several solvents of different viscosity. p exp RQ strongly depends on the viscosity of the solvent. For H p exp RQ increases from 0.17 (n‐pentane) over 0.44 (benzyl alcohol) to 0.97 (m‐cresol). For the first time experimental results clearly demonstrate that the reaction already takes place in the initial encounter, which is formed in the energy transfer from the T 1 ‐states of the hydrocarbons to molecular oxygen. The solvent dependence of p exp RQ is only caused by the solvent dependence of the total reencounter probability, p o . The results permit calculation of the probabilities per encounter (α R ) and rate, k 0 1 , for an equilibrium distribution of 1 Δ and the hydrocarbons.
Proteomic Analysis of G2/M Arrest Triggered by Natural Borneol/Curcumin in HepG2 Cells, the Importance of the Reactive Oxygen Species-p53 Pathway (2015)

Curcumin (Cur), an active ingredient from the rhizome of the plant Curcuma longa, has wide anticancer activities. However, due to its poor solubility and hence poor absorption, Cur has limited clinical applications. It is therefore important to develop an effective method to improve its absorption. Natural borneol (NB), a terpene and bicyclic organic compound, has been extensively used as a food additive, and our previous studies show that it can improve the uptake of Cur in cancer cells. However, the anticancer mechanism of NB/Cur remains unclear. In this study, the effects of NB/Cur on HepG2 cells were investigated by proteomic analysis. The results showed that 32 differentially expressed proteins identified by matrix assisted laser desorption ionization time-of-flight mass spectrometry were significantly changed after NB/Cur treated HepG2 cells for 24 h. Moreover, 17 proteins increased and 12 proteins decreased significantly. Biological progress categorization demonstrated that the identified proteins were mainly associated with cell cycle and apoptosis (28.1%). Subcellular location categorization exhibited that the identified proteins were mainly located in nucleus (28.1%) and mitochondrion (21.9%). Among of all proteins, we selected three differential proteins (hnRNPC1/C2, NPM, and PSMA5), which were associated with the p53 pathway. Down-regulation of hnRNPC1/C2 and NPM contributed to the enhancement of phosphorylated p53. Activated p53 and down-regulation of PSMA5 resulted in an increase in p21 protein. Further studies showed that NB/Cur induced reactive oxygen species (ROS) generation, indicating that ROS might be upstream of the G2/M arrest signaling pathway. In summary, the results exhibited the whole proteomic response of HepG2 cells to NB/Cur, which might lead to a better understanding of its underlying anticancer mechanisms.
Parallelizing Trusted Execution Environments for Multicore Hard Real-Time Systems (2019)

Real-Time systems are defined not only by their logical correctness but also timeliness. Modern real-time systems, such as those controlling industrial plants or the flight controller on UAVs, are no longer isolated. The same computing resources are shared with a variety of other systems and software. Further, these systems are increasingly being connected and made available over the internet with the rise of Internet of Things and the need for automation. Many real-time systems contain sensitive code and data, which not only need to be kept confidential but also need protection against unauthorized access and modification. With the cheap availability of hardware supported Trusted Execution Environments (TEE) in modern day microprocessors, securing sensitive information has become easier and more robust. However, when applied to real-time systems, the overheads of using TEEs make scheduling untenable. However, this issue can be mitigated by judiciously utilizing TEEs and capturing TEE operation peculiarities to create better scheduling policies. This thesis provides a new task model and scheduling approach, Split-TEE task model and a scheduling approach ST-EDF. It also presents simulation results for 2 previously proposed approaches to scheduling TEEs, T-EDF and CT-RM.
Grinding the Cubes─Multigram Solid-State Synthesis of Silsesquioxane Amic Acids (2021)

For the first time, ball milling is used in the functionalization of silsesquioxanes. The solid-state nucleophilic addition of aminopropylisobutyl POSS to cyclic anhydrides leads to silsesquioxane amic acids in virtually quantitative yields without the use of a solvent. The reactions are easily scalable and can be adopted to multigram quantities.