gebhart/patrepeval huggingface dataset:
High Resolution Surface Reconstruction from Multi-view Aerial Imagery (2012)

This paper presents a novel framework for surface reconstruction from multi-view aerial imagery of large scale urban scenes, which combines probabilistic volumetric modeling with smooth signed distance surface estimation, to produce very detailed and accurate surfaces. Using a continuous probabilistic volumetric model which allows for explicit representation of ambiguities caused by moving objects, reflective surfaces, areas of constant appearance, and self-occlusions, the algorithm learns the geometry and appearance of a scene from a calibrated image sequence. An online implementation of Bayesian learning precess in GPUs significantly reduces the time required to process a large number of images. The probabilistic volumetric model of occupancy is subsequently used to estimate a smooth approximation of the signed distance function to the surface. This step, which reduces to the solution of a sparse linear system, is very efficient and scalable to large data sets. The proposed algorithm is shown to produce high quality surfaces in challenging aerial scenes where previous methods make large errors in surface localization. The general applicability of the algorithm beyond aerial imagery is confirmed against the Middlebury benchmark.
Impact of Uniform Facets on the Thermodynamics of Ligand Exchanges on Colloidal Quantum Dots (2023)

Nanocrystal surfaces play a critical role in dictating their physical and chemical properties. Colloidal semiconductor nanocrystals, or quantum dots, are generally synthesized with insulating aliphatic ligands, but these ligands can be post-synthetically exchanged with other molecular species for a variety of applications. While previous work has investigated the thermodynamics of ligand exchanges on quasi-spherical quantum dots through sensitive isothermal titration calorimetry and 1H NMR measurements, the influence of well-defined crystal facets on the propensity of these ligand exchanges is yet to be explored using these techniques. We studied the exchange of native cadmium carboxylate ligands for zinc chloride ligands on (111) faceted cadmium selenide tetrahedrons and (100) faceted cadmium selenide cubes. From these measurements, we find the unexpected result that the thermodynamics of this ligand exchange between these facets is nearly identical. Further, a modified Ising model was used to fit both the calorimetric and 1H NMR data to extract thermodynamic parameters for the exchange. These simulations suggest that the observed enthalpic differences can be mostly attributed to varying inter-ligand interactions on the (111) and (100) facets.
Finesse in Face Lifting: The Role of Facial Fat Compartment Augmentation in Facial Rejuvenation (2018)

Much of facial aging can be attributed to volume deflation and tissue laxity. Successful surgical rejuvenation can be achieved through volume restoration with autologous fat grafting of the facial fat compartments. In conjunction with volume restoration, correction of tissue laxity and recontouring of the face and neck can be achieved. Current strategies for surgical correction of the face and neck involve superficial musculoaponeurotic system manipulation, medial platysma plication, and lateral platysma tightening through the lateral platysma window. These combined techniques facilitate optimal results in facial rejuvenation.
Yeast-Based Screen to Identify Natural Compounds with a Potential Therapeutic Effect in Hailey-Hailey Disease (2018)

The term orthodisease defines human disorders in which the pathogenic gene has orthologs in model organism genomes. Yeasts have been instrumental for gaining insights into the molecular basis of many human disorders, particularly those resulting from impaired cellular metabolism. We and others have used yeasts as a model system to study the molecular basis of Hailey-Hailey disease (HHD), a human blistering skin disorder caused by haploinsufficiency of the gene <i>ATP2C1</i> the orthologous of the yeast gene <i>PMR1</i>. We observed that <i>K. lactis</i> cells defective for <i>PMR1</i> gene share several biological similarities with HHD derived keratinocytes. Based on the conservation of ATP2C1/PMR1 function from yeast to human, here we used a yeast-based assay to screen for molecules able to influence the pleiotropy associated with <i>PMR1</i> deletion. We identified six compounds, Kaempferol, Indirubin, Lappaconite, Cyclocytidine, Azomycin and Nalidixic Acid that induced different major shape phenotypes in <i>K. lactis</i>. These include mitochondrial and the cell-wall morphology-related phenotypes. Interestingly, a secondary assay in mammalian cells confirmed activity for Kaempferol. Indeed, this compound was also active on human keratinocytes depleted of ATP2C1 function by siRNA-treatment used as an in-vitro model of HHD. We found that Kaempferol was a potent NRF2 regulator, strongly inducing its expression and its downstream target <i>NQO1</i>. In addition, Kaempferol could decrease oxidative stress of ATP2C1 defective keratinocytes, characterized by reduced NRF2-expression. Our results indicated that the activation of these pathways might provide protection to the HHD-skin cells. As oxidative stress plays pivotal roles in promoting the skin lesions of Hailey-Hailey, the NRF2 pathway could be a viable therapeutic target for HHD.
Hole spin initialization in quantum dots by a periodic train of short pulses (2010)

11th International Conference on Optics of Excitons in Confined Systems, Univ Autonoma Madrid, SPAIN, SEP 07-11, 2009
Prediction of individual response to anticancer therapy: historical and future perspectives (2014)

Since the introduction of chemotherapy for cancer treatment in the early 20th century considerable efforts have been made to maximize drug efficiency and at the same time minimize side effects. As there is a great interpatient variability in response to chemotherapy, the development of predictive biomarkers is an ambitious aim for the rapidly growing research area of personalized molecular medicine. The individual prediction of response will improve treatment and thus increase survival and life quality of patients. In the past, cell cultures were used as in vitro models to predict in vivo response to chemotherapy. Several in vitro chemosensitivity assays served as tools to measure miscellaneous endpoints such as DNA damage, apoptosis and cytotoxicity or growth inhibition. Twenty years ago, the development of high-throughput technologies, e.g. cDNA microarrays enabled a more detailed analysis of drug responses. Thousands of genes were screened and expression levels were correlated to drug responses. In addition, mutation analysis became more and more important for the prediction of therapeutic success. Today, as research enters the area of -omics technologies, identification of signaling pathways is a tool to understand molecular mechanism underlying drug resistance. Combining new tissue models, e.g. 3D organoid cultures with modern technologies for biomarker discovery will offer new opportunities to identify new drug targets and in parallel predict individual responses to anticancer therapy. In this review, we present different currently used chemosensitivity assays including 2D and 3D cell culture models and several -omics approaches for the discovery of predictive biomarkers. Furthermore, we discuss the potential of these assays and biomarkers to predict the clinical outcome of individual patients and future perspectives.
Exchange Field-Mediated Magnetoresistance in the Correlated Insulator Phase of Be films (2012)

We present a study of the proximity effect between a ferromagnet and a paramagnetic metal of varying disorder. Thin beryllium films are deposited onto a 5 nm thick layer of the ferromagnetic insulator EuS. This bilayer arrangement induces an exchange field, H(ex), of a few tesla in low-resistance Be films with sheet resistance R≪R(Q), where R(Q)=h/e2 is the quantum resistance. We show that H(ex) survives in very high-resistance films and, in fact, appears to be relatively insensitive to the Be disorder. We exploit this fact to produce a giant low-field magnetoresistance in the correlated-insulator phase of Be films with R≫R(Q).
Abstract 2124: Analysis of the functional relevance of novel alternative splicing events in non-small cell lung cancer (2015)

Abstract Lung cancer is the most common cause of death by cancer worldwide. Deregulation of alternative splicing (AS) is becoming increasingly relevant for the understanding of the molecular mechanisms of lung tumor progression. Genome-wide microarrays containing probes in exons and junctions can be used to identify differential AS events. We developed an algorithm, called ExonPointer, which was optimized to detect AS events using this kind of platforms. Using this technique, we successfully detected splicing events regulated by the oncogene serine/arginine-rich splicing factor 1 (SRSF1) in lung cancer cell lines. Moreover, four of these genes, ATP11C, IQCB1, TUBD1 and PRRC2C, showed a significantly different pattern of AS in primary non-small cell lung cancer (NSCLC) compared with normal lung tissue. In the case of PRRC2C, we also demonstrated that the deregulation of the splicing event was important for tumor progression. We next applied the same technique to target differential AS events in NSCLC primary tissues (13 lung squamous cell carcinomas and 9 lung adenocarcinomas). Their paired normal lung tissues were used as reference. The validation rate for the top 20 events identified by ExonPointer was 70%. Gene cluster analyses showed an enrichment of clusters implicated in cancer development such as Cellular Growth and Proliferation, or Cell Death and Survival. Among others, we observed accumulation of a tumor-specific splice variant in Mitogen-Activated Protein Kinase 9 (MAPK9 or JNK2). The tumor-specific variant for this gene contains an alternative exon 2 which causes a frame shift introducing a premature stop codon. Functional analyses using isoform-specific siRNAs showed that this variant did not affect tumor growth or progression. However, its expression significantly correlated with the expression of Regulator of Nonsense Transcripts 3A and B (UPF3A and UPF3B) in 42 lung cancer cell lines. These proteins belong to the Nonsense Mediated Decay (NMD) pathway, which eliminates aberrant mRNA transcripts, suggesting that the presence of some aberrant AS variants in lung cancer are caused by a malfunction of NMD. In conclusion, we have developed a reliable tool for the high throughput analysis of AS, and have identified new splicing events in lung cancer that can be studied as potential diagnostic markers and therapeutic targets. Citation Format: Fernando J. de Miguel, Ravi D. Sharma, Pablo Reclusa, María J. Pajares, Angel Rubio, Ruben Pio, Luis M. Montuenga. Analysis of the functional relevance of novel alternative splicing events in non-small cell lung cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2124. doi:10.1158/1538-7445.AM2015-2124
Down‐Regulation of AMPA Receptor Subunit GluR2 in Amygdaloid Kindling (1995)

Alterations in glutamatergic transmission are postulated to be important in kindling and epilepsy. The levels of alpha-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid (AMPA) receptor subunits (GluR1, 2, and 4) were compared in amygdala-kindled and sham-operated animals using subunit-specific antibodies and quantitative western blotting. Four limbic regions were examined: limbic forebrain, piriform cortex/amygdala, hippocampus, and entorhinal cortex. When subunit levels were examined 24 h after the last stage 5 seizure, levels of GluR2 were found to be selectively reduced in limbic forebrain (30%) and piriform cortex/amygdala (25%), with no changes in other regions examined. In addition, no changes in the other subunits were observed in any region. The decrease in GluR2 that was observed in kindled animals at 24 h was no longer present at 1 week and 1 month after the last stage 5 seizure. Because the GluR2 subunit uniquely determines the calcium permeability of these receptors and because the piriform cortex has been implicated as a source of excitatory drive for limbic seizures, reduced GluR2 expression may be important in increasing neuronal excitability in kindling-induced epilepsy, or may reflect a compensatory mechanism resulting from kindling.
16.2: A New IC for Generating AC Power Supply for Column PDP Addressing (2000)

Abstract Some key factors for the addressing electronic of plasma display panels are the reduction of power consumption and the control of EMI emissions during driver switching. An usual solution to decrease the power dissipation is to use a AC power supply based on a L, C resonant approach. The STV7801S is the first IC that integrates all the components necessary to implement a resonant AC power supply to drive the columns of a PDP. This circuit is commonly named DPS for Data Power Switch. With an external inductance, the STV7801S circuit charges and discharges the PDP column capacitance to recover over 80% of the energy normally lost in driving the panel capacitance with DC power supply.
FigureS4 from AsiDNA Is a Radiosensitizer with no Added Toxicity in Medulloblastoma Pediatric Models (2023)

&lt;p&gt;RNA-Seq analysis in HDMB03 and DAOY upon treatment.&lt;/p&gt;
Typing, Copy, and Search (2012)

In this chapter, we will show you some good ways to type on your iPod touch and save valuable time when doing so. Along the way, we'll show you how to use the Portrait (vertical/smaller) and Landscape (horizontal/larger) keyboards. We will also teach you how to select different language keyboards, how to type symbols, and other tips.KeywordsSpell CheckerType SymbolEntire ScreenHome ScreenMail MessageThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Characterization of yttria-stabilized zirconia films deposited by dip-coating on La0.7Sr0.3MnO3 substrate: Influence of synthesis parameters (2013)

Yttria-stabilized zirconia (YSZ, ZrO2-8%Y2O3) films were deposited onto lanthanum strontium manganite (LSM, La0.7Sr0.3MnO3) substrates using dip-coating process aiming for the application in solid oxide fuel cells (SOFCs). YSZ precursor was prepared by sol-gel method; three values of the organic/inorganic concentration ratio (1, 3 and 5) were utilized and the sol viscosity was adjusted (60 mPa·s and 100 mPa·s) before deposition on the substrate. The influence of these synthesis parameters on the structure and morphology of the deposited films was examined by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The films showed characteristic peaks of LSM, YSZ (with cubic structure) and secondary phases of SrZrO3 and La2O3. Depending on the synthesis conditions, crack-free, homogeneous and well adhered films were obtained, with thickness of 11–24 μm.
Mortality associated with systemic candidiasis in children. (1997)

The purpose of this study was to determine factors associated with an increased risk of mortality due to systemic Candida infections in children hospitalized at our tertiary care facility. A total of 71 cases of Candida bloodstream infections were identified over a 2-year period. The attack rate was 47 cases of candidemia per 10,000 discharges and the case fatality rate was 46.5%. Sixty-one cases occurred in infants under 2 years; 27 were newborns (38%). Using logistic regression analysis, we evaluated the independent effects of potential risk factors for death due to candidemia. Three factors were associated with the subsequent risk for death due to systemic candida infection: malnutrition (OR = 4.3; 95% CI 1.2-14.8), prior surgery (OR = 3.8; 95% CI 1.2-13.2), and the number of days between the first positive candida blood culture and the onset of antifungal treatment (OR = 1.12; 95% CI 1.06-1.25). Newborns showed an almost three times greater risk of death due to candidemia as compared to other age groups, but this association was only marginally significant (OR = 2.8; 95% CI 0.9-9.3). There was no difference in the rate of candidemia between the 2 years of the study; however, the observed mortality declined significantly from 65% in year one to 20% in year two (p = 0.02). The major finding of this study was to observe that for every day treatment was delayed the risk of death increased significantly. Thus, this study provides support for empirical antifungal therapy early in the course of suspected systemic candidiasis in order to improve survival among children.
Parapharyngeal space masses: an updated protocol based upon 104 cases. (1984)

Surgical and CT examinations of 104 patients, each of whom presented with a parapharyngeal space mass, has resulted in the development of an updated CT protocol designed to provide a preoperative diagnosis. When dynamic scanning is used, diagnostic angiography or digital venous imaging (DVI) can be avoided in almost all of these cases. A specific preoperative diagnosis can be made in 88% of the patients and a limited differential diagnosis, which includes the final diagnosis, can be made in virtually all cases. The protocol and the problems encountered in differential diagnosis are presented. Evidence to suggest that minor salivary gland benign mixed tumors may arise in salivary rest tissue, rather than pharyngeal mucosal glands, is also presented.
Strained Enamines as Versatile Intermediates for Stereocontrolled Construction of Nitrogen Heterocycles. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Measurement of Coronary Sinus Blood Flow by Continuous Thermodilution in Man (1971)

A technique was developed for measurement of blood flow in the coronary sinus in man by continuous thermodilution. For single determinations, 5% dextrose at room temperature is injected at a constant rate of 35 ml/min for a period of about 20 sec. In 14 subjects with normal coronary arteries the mean coronary sinus blood flow was 122 ± 25 ml/min (range, 83 to 159 ml/min). The blood flow computed per 100 g of left ventricle was 82 ± 16 ml/min, which is in the range of values obtained by nitrous oxide and coincidence counting methods. In 35 patients with arteriographically confirmed coronary artery disease the mean flow was similar (128 ± 20 ml/min; range, 92 to 167 ml/min). A special catheter was used for simultaneous measurement of blood flow in the coronary sinus and great cardiac vein. In eight normal subjects the mean great cardiac vein flow was 68 ± 11 ml/min (range, 51 to 78 ml/min) or 65 ± 10% of the coronary sinus blood flow. The method allowed continuous measurement of flow over a period of several minutes and, for the first time, measurement of rapid changes in myocardial perfusion.
PGE2 Upregulates Activation-Induced Cytosine Deaminase (AID) in Human B Lymphoblasts (34.12) (2009)

Abstract AID is expressed in mature B cells during activation and in some non-lymphoid tissues during inflammation and malignancy. Elevated COX-2 &amp; PGE2 characterize all the above and may be involved. We here confirm that PGE2 enhances AID in activated human B2 cells (J Immunol. 178:35.4, 2007 abstract) and explore the mechanism. AID was assessed, by immunoblotting and two-color flow cytometry of CFSE-labeled cells, following activation by anti-IgM:anti-CD21:dex + IL-4 + BAFF w/wo PGE2 or agonists/antagonists of PGE2 receptors (EP1, EP2, EP3, and EP4). PGE2 added at physiological doses augmented AID. EP2 was involved on the basis of (a) AID-augmenting effects of an EP2-specific agonist and (b) concordant upregulation of AID and EP2 on replicating blasts. Furthermore, PGE2-mediated elevation of AID was thwarted by inhibitors of PKA, downstream of EP2. To examine whether autocrine PGE2 synthesis contributes to AID, replicating cells were assessed for mPGE2-1 - an enzyme that converts COX-2-generated PGH2 to PGE2. Elevated mPGE2-1 in progeny and COX-2 inhibitor-reduced AID both suggest that autocrine PGE2 promotes AID. Additionally, functional AID (on the basis of IgG+ progeny) was elevated and reduced by exogenous PGE2 and COX-2 inhibitors, respectively. Thus PGE2, elaborated by classic inflammatory cells or generated during activation, augments AID expression/function in EP2-expressing human B lymphoblasts. NIH R01 AI52189; M01 General Clinical Research Center grant RR018535; and Karches Foundation
Effect of feeding piglets with different extruded and nonextruded cereals on the gut mucosa and microbiota during the first postweaning week1 (2012)

Two trials were conducted to evaluate the effect of different cereals in piglet diets on the jejunal mucosa and the ileal and cecal microbiota during the first postweaning days. In Trial 1, 48 newly weaned pigs (7.95 kg BW; 26 d of age) were individually housed and distributed among 3 experimental diets containing white rice (Oryza sativa), naked oats (Avena sativa), or barley (Hordeum vulgare) as the cereal source. At the start of the trial (weaning; day 0), 12 piglets were slaughtered and sampled to obtain initial reference values for histology and microbiology determinations. Additionally, 4 pigs per treatment per day were slaughtered and sampled at days 1, 2, and 6 postweaning. Villus height (VH), crypt depth (CD), and intraepithelial lymphocytes (IEL) in jejunal mucosa were measured, and microbiota in ileal and cecal digesta were evaluated by RFLP. The Manhattan distances between RFLP profiles were calculated and, for each treatment and sampling day, intragroup similarities (IGS) were estimated. In Trial 2, an additional 48 piglets were used (7.56 kg BW; 26 d of age), and the same experimental procedures were performed except that the 3 experimental diets contained extruded white rice, extruded naked oats, or extruded barley as the cereal source. A reduction in VH was observed in both trials from day 0 to 6 (P < 0.05). In Trial 1 (raw cereals), more IEL and deeper crypts were observed for the barley than for the naked oats based diets (P < 0.05). In Trial 2, no differences among extruded cereals were observed for the histological parameters. In Trial 1, feeding naked oats resulted in lower IGS (increased heterogeneity) of the microbiota in the ileum and in the cecum compared to rice and barley (P < 0.05). In Trial 2, the pigs fed extruded barley had lower IGS in the ileum than those fed extruded naked oats and extruded rice whereas in the cecum, both extruded barley and extruded rice resulted in lower IGS than extruded naked oats (P < 0.05). It is concluded that cereal nature affects the composition of the microbiota and the morphology of the gut mucosa in newly weaned pigs.
ChemInform Abstract: Reaction Between Trioxodinitrate and the Pentaamminenitrosylruthenium(II) Cation. (1987)

Abstract The reaction between N 2 O 3 2‐ and Ru(NH 3 ) 5 NO 3+ , which is investigated over the pH range 6‐14, results at pH ∼ 10 in rapid formation of NO followed by much slower development of N 2 O and N2, in relative proportions that vary with pH.