gebhart/patrepeval huggingface dataset:
From Polyolefins to New Polymeric Materials (2003)

Dopo una breve rassegna delle eccezionali proprietà dei sistemi catalitici scoperti da Giulio Natta e delle numerose strutture poliolefiniche derivate, il presente lavoro descrive alcuni processi che, sviluppatisi successivamente, ma ispirati sempre dagli studi di Natta, permettono di formulare e produrre una serie di nuovi materiali strutturalmente complessi (eterofasici) in cui le poliolefine continuano a giocare un ruolo essenziale grazie alle loro versatili proprietà termomeccaniche.
Lossy compression of images corrupted by film grain noise (2002)

Noise degrades the performance of any image compression algorithm. This paper studies the effect of film-grain noise on lossy image compression. Since the goal of lossy image compression algorithms is to achieve the best fidelity for a given bit rate, the distortion is measured with respect to the original image not with respect to the input to the coder. The results of noisy source coding are used to develop this coder. The minimum-mean-squared-error (MMSE) coder involves MMSE restoration of the noisy image. This paper presents an MMSE image restoration algorithm based on modeling the image as a Markov random field. The performance of this preprocessing step is also studied when using JPEG.
Control of Translation in Cultured Cells: Continued Synthesis and Accumulation of Messenger RNA in Nondividing Cultures (1974)

Nontransformed animal fibroblasts in tissue culture regulate total protein and ribosomal RNA synthesis coordinately with changes in the cellular growth state. Here it is shown that the amounts and rates of synthesis of cytoplasmic poly(A)-containing RNA, presumed to be mRNA, do not appreciably change with alterations in growth state. In nongrowing (resting) cultures of BALB/c 3T3 cells presumptive mRNA molecules predominantly accumulate as cytoplasmic ribonucleoprotein particles; the RNA from which can be chased into the polyribosomal structure upon activation of the resting cultures with animal sera. It is suggested that the decreased protein synthetic rate in resting as compared with growing cells is in part due to a failure of preexisting mRNAs to attach to ribosomes and that addition of serum to the tissue culture medium can partially overcome this translational lesion.
Pangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts (2021)

Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which can be found in a much wider range of mammalian hosts. Despite C. hyointestinalis being reported as an emerging pathogen, its evolutionary and host-associated diversification patterns are still vastly unexplored. For this reason, we generated whole-genome sequences of 13 C. hyointestinalis subsp. hyointestinalis strains and performed a comprehensive comparative analysis including publicly available C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii genomes, to gain insight into the genomic variation of these differentially-adapted subspecies. Both subspecies are distinct phylogenetic lineages which present an apparent barrier to homologous recombination, suggesting genetic isolation. This is further supported by accessory gene patterns that recapitulate the core genome phylogeny. Additionally, C. hyointestinalis subsp. hyointestinalis presents a bigger and more diverse accessory genome, which probably reflects its capacity to colonize different mammalian hosts unlike C. hyointestinalis subsp. lawsonii that is presumably host-restricted. This greater plasticity in the accessory genome of C. hyointestinalis subsp. hyointestinalis correlates to a higher incidence of genome-wide recombination events, that may be the underlying mechanism driving its diversification. Concordantly, both subspecies present distinct patterns of gene families involved in genome plasticity and DNA repair like CRISPR-associated proteins and restriction-modification systems. Together, our results provide an overview of the genetic mechanisms shaping the genomes of C. hyointestinalis subspecies, contributing to understand the biology of Campylobacter species that are increasingly recognized as emerging pathogens.
On Optimizing MMVEs in Network-Aware Clouds (2014)

Network operators will soon cooperate with traditional cloud providers to offer network-virtualization-based converged cloud services, which are referred to as network-aware clouds. Network-aware clouds allow network operators to share income with Over-The-Top (OTT) providers by providing them with end-to-end network QoS guarantees. For MMVE providers, leveraging the computation, storage, and communication resources offered by network-aware clouds for the best MMVE QoE levels is crucial to their success. In this paper, we point out a main research challenge: optimally placing various fine-grained MMVE tasks across heterogeneous clouds, which provide diverse computation and storage QoS guarantees (in data centers) and communication QoS guarantees (end-to-end). Via real experiments, we demonstrate the potential of network-aware clouds on improving the QoE of MMVEs. Achieving the optimal QoE level, however, is no easy task because of the dynamic nature of networks and virtual environments and the complex interplay between cloud QoS guarantees and MMVE QoE metrics, such as responsiveness, precision, and fairness. Throughly addressing the task placement problem is our current work.
Quality Indicators in Critical Access Hospitals, Small Rural, and Urban Hospitals (2023)

Purpose: Critical Access Hospitals (CAHs) have served their rural communities since they were created in the 1990s. CAHs have been exempt from the multiple organizational performance-based approaches that use financial incentives and thus quality indicators targeting CAHs specifically do not exist. Reports have suggested indicators that are appropriate for rural hospitals and CAHs but none have included all types of quality indicators - structures, work processes, outcomes, and quality improvement (QI) activities. Using a subset of the National Database of Nursing Quality Indicators® (NDNQI®) we assessed whether existing indicators for the work environment (structure), patient - and nurse outcomes are appropriate for CAHs. Methods: Using 2017 NDNQI® data on 16 structure and outcome indicators (8 work environment, 6 patient- and 2 nurse outcomes) were extracted. Employing bootstrapped confidence intervals CAHs were compared to other small (less than 50 beds) rural and urban hospitals. Findings: 103 CAHs, 63 small rural hospitals and 91 small urban hospitals had data on at least one indicator (range 87-239 for each indicator). There were no differences between CAHs and other small rural and urban hospitals for 15 of the 16 quality indicators. CAHs had fewer bachelor prepared nurses compared to urban hospitals. Conclusion: Our results suggest that quality indicators for structure and outcomes currently used in approximately 2000 hospitals are also applicable for CAHs. Whether they apply to all 1350 CAHs and can be used to guide benchmarking and QI in CAHs needs further study. Keywords: Critical Access Hospitals, Quality Indicators, National Database of Nursing Quality Indicators®DOI: https://doi.org/10.14574/ojrnhc.v23i1.733
Plasminogen Activator Inhibitor‐1 after Acute Myocardial Infarction in Obstructive Sleep Apnea Patients (2018)

Background Acute cardiac and vascular events, including myocardial infarction (MI) exhibit a peak onset between 6 AM and 11 AM. Plasminogen activator inhibitor‐1 (PAI‐1) is a main inhibitor of tissue‐plasminogen activator and a key indicator of prothrombotic state. Elevated levels of PAI‐1 have been linked to increased cardiac and vascular risk. Obstructive sleep apnea (OSA) has also been associated with increased risk of MI. Hypoxemia, as well as OSA, increase PAI‐1. We tested the hypothesis that the early morning after awakening is associated with higher PAI‐1 activity in subjects with acute MI who also have OSA. Methods We studied 56 subjects after acute myocardial infarction (mean age 60±2 years; BMI 28±1 kg/m 2 ). All subjects underwent complete overnight sleep polysomnography within 2 weeks after MI to assess for presence and severity of OSA. PAI‐1 activity was measured in all 56 subjects, first before sleep (at 9 PM), and then immediately after awakening in the morning (at 6 AM). A third measurement of PAI‐1 was obtained in all subjects at 11 AM. Results For the group, PAI‐1 activity almost doubled from 12.5±1.6 U/mL at 9 PM to 22.5±2.5 U/mL after waking at 6 AM and decreased to 14.2±2.4 U/mL by 11 AM (P&lt;0.0001). Fifty seven percent of patients were observed to have OSA, with apnea hypopnea index of &gt;10 events/hour. Sleep apnea did not contribute to further elevation of morning PAI‐1 activity level in acute MI patients (9 PM, 6 AM and 11 AM PAI‐1 activity respectively: no OSA 11.6±2.5 U/mL, 24.1±3.8 U/mL and 15.2±3.5 U/mL; OSA 13.3±2.1 U/mL, 21.1±3.3 U/mL and 13.3±3.3 U/mL; P=0.8 for between group comparison). Conclusions Increased PAI‐1 activity in acute MI patients may be an important mechanism underlying the early morning peak in cardiovascular events. The presence of OSA however does not appear to further accentuate the already elevated PAI‐1 activity in acute MI patients. In patients after acute MI, the diurnal variation in PAI‐1, rather than apnea, may drive the impaired fibrinolysis. Support or Funding Information ‐‐R01 grant HL65176‐‐This study was also supported in part by a gift to the Mayo Foundation by the Philips Respironics Foundation. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Fast Evaluation of Fluctuations in Biochemical Networks With the Linear Noise Approximation (2003)

Biochemical networks in single cells can display large fluctuations in molecule numbers, making mesoscopic approaches necessary for correct system descriptions. We present a general method that allows rapid characterization of the stochastic properties of intracellular networks. The starting point is a macroscopic description that identifies the system's elementary reactions in terms of rate laws and stoichiometries. From this formulation follows directly the stationary solution of the linear noise approximation (LNA) of the Master equation for all the components in the network. The method complements bifurcation studies of the system's parameter dependence by providing estimates of sizes, correlations, and time scales of stochastic fluctuations. We describe how the LNA can give precise system descriptions also near macroscopic instabilities by suitable variable changes and elimination of fast variables.
Density functional studies of Rb+ hydration: Probing the analogy between Rb+ & K+ in K-channels[. (2016)

Abstract not provided.
Dually folate/CD44 receptor-targeted self-assembled hyaluronic acid nanoparticles for dual-drug delivery and combination cancer therapy (2017)

Nanoparticles (NPs) functionalized with targeting ligands have shown promise, but are still limited by their nonspecific uptake by certain healthy tissues and cells that express low or even comparable levels of receptors. To increase their accumulation at tumor sites while decreasing the unintended toxicity, a possible solution is the involvement of two separate tumor-specific ligands in the localization. In this study, a dual tumor-targeting drug-loaded NP system was self-assembled by the amphiphilic conjugate of methotrexate-hyaluronic acid-octadecylamine (MTX-HA-OCA) with curcumin (CUR) encapsulated within the hydrophobic core (designated as MTX-HA-OCA/CUR NPs). The advantages of this nanosystem are that the anticancer drug MTX can be utilized as a tumor-targeting ligand toward folate receptors due to its structural similarity to folic acid (FA), and HA can serve as another tumor-targeting ligand toward CD44 receptors. The MTX-HA-OCA/CUR NPs are ∼70 nm in diameter and have sustained/controlled drug release behavior. An in vitro cellular uptake and competition inhibition study exhibited that MTX-HA-OCA/CUR NPs could significantly enhance the internalization efficiency in HeLa cells via folate/CD44 receptor-mediated endocytosis as compared to HA-OCA/CUR NPs. More importantly, the in vitro cytotoxicity of MTX-HA-OCA/CUR NPs was significantly enhanced as compared to those of the HA-OCA/CUR NPs, both free drugs, and individual free drug. Furthermore, the real-time in vivo and ex vivo fluorescence imaging of HeLa tumor-bearing mice showed that MTX-HA-OCA/CUR NPs could more efficiently enhance their accumulation and improve the penetration at the tumor site as compared to HA-OCA/CUR NPs. Therefore, these dually folate/CD44 receptor-targeted self-assembled HA NPs for the co-delivery of both anticancer drugs might provide a promising strategy for dual-targeted combination cancer therapy.
Induction of reporter gene expression by inhibitors of histone deacetylase. (1998)

The relationship between histone acetylation and induction of gene expression was studied in Ros 17/2.8 rat osteosarcoma cells transfected with the pCH110 plasmid. This plasmid is commonly used in cotransfections as a measure of transfection efficiency. Cells were incubated for 48 hours with sodium butyrate, phenylbutyrate, 3-bromopropionate or trichostatin A. There was an approximate relationship between the extent of beta-galactosidase induction and the degree of histone hyperacetylation. Trichostatin A was the most effective agent followed by sodium butyrate and then phenylbutyrate. The toxicity of 3-bromopropionate made it difficult to compare its action with the other agents. Phenylbutyrate was less effective than sodium butyrate in causing induction of gene expression and histone hyperacetylation but this action may be a factor in the growth-inhibitory and differentiating activity of phenylbutyrate which has also been attributed to glutamine depletion.
Zoalene and Anot Residues in Chickens Fed Zoalene and Various Antibiotics (1961)

ZOALENE (3,5-dinitro-o-toluamide) is a new coccidiostat intended for use in feed as an aid in the prevention and control of both intestinal and caecal coccidiosis in chickens. The drug is available as Zoamix* premix, containing 25 percent zoalene, which is used in preparing finished medicated feeds bearing 0.0063 to 0.0125 percent zoalene. Zoalene medicated feeds are fed continuously to broiler chickens up to the time of slaughter since no withdrawal period is required. Safety tests indicate that zoalene medicated feed does not affect egg production, quality, fertility, or the chicken itself. Metabolism studies (Smith et al, 1957) have shown that some of the zoalene is rapidly converted by the chicken to Anot (3-amino-5-nitro-o-tolu-amide). When chickens on zoalene medicated diets are sacrificed with no with-drawal period, residues of zoalene and Anot are found in the tissues. In clearing zoalene for the market the Federal Food and Drug Administration issued a food…
Low-Frequency Positive Pressure Ventilation with Extracorporeal Carbon Dioxide Removal (LFPPV-ECCO2R) (1978)

We describe a new form of mechanical pulmonary ventilation, low-frequency positive pressure ventilation with extracorporeal CO2 removal (LFPPV-ECCO2R). In a series of animal studies the rate of mechanical ventilation was 0.66, 1, 2, and 4 min−1 at a tidal volume of 3, 10, and 15 ml kg−]. We were able to maintain normal blood gases and normal lung volumes and lung mechanics even at the lowest ventilator rate with tidal volumes of 10 or 15 ml kg−1. Each experiment lasted 7 hours. Our data suggest a possible new dimension in the management of a difficult patient on mechanical pulmonary ventilation.
Difficult Biliary Cannulation in the ERCP: Repeated Ercp After Precut, Percutaneous Or EUS Guided Alternative Procedure? Analysis in a Tertiary Care Center (2021)

Aims: Introduction ERCP is the standard procedure for biliary drainage. In case of difficult biliary access alternative procedures consist of precut intervention with repeated ERCP, percutaneous access or EUS guided intervention. We analyzed frequency and success rate of used procedures in the daily praxis.
Palladacyclen als effiziente Katalysatoren für Arylkupplungsreaktionen (1995)

Die katalytische C‐C‐Kupplung von Chlorarenen sowohl durch Heck‐ als auch durch Suzuki‐Reaktion gelingt erstmals mit neuen Palladacyclen vom Typ 1 mit R beispielsweise o ‐Tolyl oder Mesityl. Sie sind um Größenordnungen aktiver als herkömmliche Katalysatoren und darüber hinaus auch thermisch erheblich robuster. Vor allem unterbleiben die Spaltung von P‐C‐Bindungen und die Abscheidung von Palladium. Analoge Umsetzungen von Bromarenen lassen sich mit 1 ebenfalls vorteilhaft katalysieren. – Die Heck‐Reaktion von Halogenarenen mit Vinylderivaten (z.B. n ‐Butylacrylat) führt in einem Schritt zu ( E )‐Styrolderivaten. Bei der Suzuki‐Reaktion werden Halogenarene mit Phenylboronsäure ebenfalls einstufig zu Biphenylderivaten umgesetzt.
Solid-Phase Synthesis of a Heterocyclic Ethylenediamine-Derivatized Library (2000)

ADVERTISEMENT RETURN TO ISSUEPREVReportNEXTSolid-Phase Synthesis of a Heterocyclic Ethylenediamine-Derivatized LibraryElizabeth A. Jefferson, Kelly G. Sprankle, and Eric E. SwayzeView Author Information Ibis Therapeutics, A Division of Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Carlsbad, California 92008 Cite this: J. Comb. Chem. 2000, 2, 5, 441–444Publication Date (Web):July 14, 2000Publication History Received14 April 2000Published online14 July 2000Published inissue 1 September 2000https://doi.org/10.1021/cc000027eCopyright © 2000 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views207Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (71 KB) Supporting Info (3)»Supporting Information Supporting Information SUBJECTS:Alcohols,Amines,Genetics,Organic polymers,Scaffolds Get e-Alerts
Interface de navigation musicale par le contenu (2007)

cote interne IRCAM: Peeters07a
OFDM receivers with iterative nonlinear distortion cancellation (2010)

We propose two practical schemes for the cancellation of nonlinear distortions caused by the power amplifiers (PA) in Orthogonal Frequency Division Multiplexing (OFDM) systems. The algorithms are iterative and located at the receiver. They utilize a soft channel decoder to improve the capabilities of the distortion estimation and relay all the computational complexity to the receiver. Simulation results show that the algorithm can improve the coded bit error rate (BER) to levels close to the linear system case.
Deep Variational Instance Segmentation (2020)

Instance Segmentation, which seeks to obtain both class and instance labels for each pixel in the input image, is a challenging task in computer vision. State-of-the-art algorithms often employ two separate stages, the first one generating object proposals and the second one recognizing and refining the boundaries. Further, proposals are usually based on detectors such as faster R-CNN which search for boxes in the entire image exhaustively. In this paper, we propose a novel algorithm that directly utilizes a fully convolutional network (FCN) to predict instance labels. Specifically, we propose a variational relaxation of instance segmentation as minimizing an optimization functional for a piecewise-constant segmentation problem, which can be used to train an FCN end-to-end. It extends the classical Mumford-Shah variational segmentation problem to be able to handle permutation-invariant labels in the ground truth of instance segmentation. Experiments on PASCAL VOC 2012, Semantic Boundaries dataset(SBD), and the MSCOCO 2017 dataset show that the proposed approach efficiently tackle the instance segmentation task. The source code and trained models will be released with the paper.
Recombinant Production of Peptide C-Terminal α-Amides Using an Engineered Intein (2013)

Peptides are of increasing interest as therapeutics in a wide range of diseases, including metabolic diseases such as diabetes and obesity. In the latter, peptide hormones such as peptide YY (PYY) and pancreatic peptide (PP) are important templates for drug design. Characteristic for these peptides is that they contain a C-terminal that is α-amidated, and this amidation is crucial for biological function. A challenge is to generate such peptides by recombinant means and particularly in a production scale. Here, we have examined an intein-mediated approach to generate a PYY derivative in a larger scale. Initially, we experienced challenges with hydrolysis of the intein fusion protein, which was reduced by a T3C mutation in the intein. Subsequently, we further engineered the intein to decrease the absolute size and improve the relative yield of the PYY derivative, which was achieved by substituting 54 residues of the 198 amino acid intein with an eight amino acid linker. The optimized intein construct was used to produce the PYY derivative under high cell density cultivation conditions, generating the peptide thioester precursor in good yields and subsequent amidation provided the target peptide.
Continuous speech recognition with a TF-IDF acoustic model (2010)

Information retrieval methods are frequently used for indexing and retrieving spoken documents, and more recently have been proposed for voice-search amongst a pre-defined set of business entries. In this paper, we show that these methods can be used in an even more fundamental way, as the core component in a continuous speech recognizer. Speech is initially processed and represented as a sequence of discrete symbols, specifically phoneme or multi-phone units. Recognition then operates on this sequence. The recognizer is segment-based, and the acoustic score for labeling a segment with a word is based on the TF-IDF similarity between the subword units detected in the segment, and those typically seen in association with the word. We present promising results on both a voice search task and the Wall Street Journal task. The development of this method brings us one step closer to being able to do speech recognition based on the detection of sub-word audio attributes.
Reciprocal information flow between prefrontal cortex and ventral tegmental area in an animal model of schizophrenia (2000)

The medial prefrontal cortex (PFC) is anatomically and functionally connected with the ventral tegmental area (VTA), the neuronal source of mesocorticolimbic system that is pathophysiologically related to schizophrenia-like symptoms. Methamphetamine (MAP) was applied to examine the functional relationship between PFC and VTA in an animal model of schizophrenia. Hyperactivity and stereotyped behavior were observed accompanied by a distinctive direction of information flow. In hyperactivity, information flow in the direction from PFC to VTA was dominant. Contrarily, dominant information flow from VTA to PFC was found in stereotyped behavior. These results indicate that dysfunctional interaction between PFC and VTA is the neuronal basis of MAP-induced schizophrenia-like psychosis. The information flow and its direction can be useful tool to explain the neurogenesis of these abnormal behaviors.