gebhart/patrepeval huggingface dataset:
Mitral Regurgitation in Patients Undergoing Noncardiac Surgery (2021)

Mitral regurgitation (MR) is one of the most frequently encountered types of valvular heart disease in the United States. Patients with significant MR (moderate-to-severe or severe) undergoing noncardiac surgery have an increased risk of perioperative cardiovascular complications. MR can arise from a diverse array of causes that fall into 2 broad categories: primary (diseases intrinsic to the valvular apparatus) and secondary (diseases that disrupt normal valve function via effects on the left ventricle or mitral annulus). This article highlights key guideline updates from the American College of Cardiologists (ACC) and the American Heart Association (AHA) that inform decision-making for the anesthesiologist caring for a patient with MR undergoing noncardiac surgery. The pathophysiology and natural history of acute and chronic MR, staging of chronic primary and secondary MR, and considerations for timing of valvular corrective surgery are reviewed. These topics are then applied to a discussion of anesthetic management, including preoperative risk evaluation, anesthetic selection, hemodynamic goals, and intraoperative monitoring of the noncardiac surgical patient with MR.
Adaptive Linear Filtering Compression on realtime sensor networks (2009)

We present a lightweight lossless compression algorithm for realtime sensor networks. Our proposed adaptive linear filtering compression (ALFC) algorithm performs predictive compression, using adaptive linear filtering to predict sample values followed by entropy coding of prediction residuals, encoding a variable number of samples into fixed-length packets. Adaptive prediction eliminates the need to determine prediction coefficients a priori and, more importantly, allows compression to dynamically adjust to a changing source. The algorithm requires only integer arithmetic operations and thus is compatible with sensor platforms that do not support floating-point operations. Significant robustness to packets losses is provided by including small but sufficient overhead data to allow samples in each packet to be independently decoded. Real-world evaluations on seismic data from a wireless sensor network testbed show that ALFC provides more effective compression and uses less resources than some other lossless compression approaches such as S-LZW. Experiments in a multi-hop sensor network also show that ALFC can significantly improve raw data throughput and energy efficiency.
Low and homogeneous copy number of plasmid‐borne symbiont genes affecting host nutrition in Buchnera aphidicola of the aphid Uroleucon ambrosiae (2003)

The bacterial endosymbiont of aphids, Buchnera aphidicola, often provides amino acids to its hosts. Plasmid amplification of leucine (leuABCD) and tryptophan (trpEG) biosynthesis genes may be a mechanism by which some Buchnera over-produce these nutrients. We used quantitative polymerase chain reaction to assess the leuABCD/trpEG copy variability within Uroleucon ambrosiae, an aphid with a wide diet breadth and range. Both leuABCD and trpEG abundances are: (i) similar for aphids across 15 populations, and (ii) low compared to Buchnera from other aphid species (particularly trpEG). Consequently, the plasmid location of trpEG combined with Buchnera's chromosomal polyploidy may functionally limit, rather than increase, tryptophan production within Uroleucon ambrosiae.
Anticollinear order and degeneracy lifting in square lattice antiferromagnet LaSrCrO4 (2022)

We report the static and dynamic magnetic properties of ${\mathrm{LaSrCrO}}_{4}$, a seemingly canonical spin-3/2 square-lattice antiferromagnet that exhibits frustration between magnetic layers---owing to their AB stacking---and offers a rare testbed to investigate accidental-degeneracy lifting in magnetism. Neutron diffraction experiments on single-crystal samples uncover a remarkable anticollinear magnetic order below ${T}_{N}$ = 170 K characterized by a N\'eel arrangement of the spins within each layer and an orthogonal arrangement between adjacent layers. To understand the origin of this unusual magnetic structure, we analyze the spin-wave excitation spectrum by means of inelastic neutron scattering and bulk measurements. A spectral gap of 0.5 meV, along with a spin-flop transition at 3.2 T, reflect the energy scale associated with the degeneracy-lifting. A minimal model to explain these observations requires both a positive biquadratic interlayer exchange and dipolar interactions, both of which are on the order of 10${}^{\ensuremath{-}4}$ meV, only a few parts per million of the dominant exchange interaction ${J}_{1}\ensuremath{\approx}11$ meV. These results provide direct evidence for the selection of a noncollinear magnetic structure by the combined effect of two distinct degeneracy lifting interactions.
Notch1 Deficiency Results in Decreased Inflammation during Wound Healing and Regulates Vascular Endothelial Growth Factor Receptor-1 and Inflammatory Cytokine Expression in Macrophages (2010)

We investigated whether Notch signaling plays a role in regulating macrophage responses to inflammation. In a wound healing assay, macrophage recruitment was decreased in Notch1(+/-) mice, and the wounds were characterized by decreased TNF-α expression. As wound healing progressed, Notch1(+/-) wounds had increased vascularization and collagen deposition compared with wild-type wounds. In mice with myeloid-specific Notch1 deletion, wounds had decreased macrophage recruitment as well as decreased TNF-α expression, indicating the specific role of Notch1 in the inflammatory response in these cells. In vitro, we found that vascular endothelial growth factor receptor-1 (VEGFR-1) was upregulated in macrophages in response to LPS/IFN-γ and that this upregulation depended on Notch signaling. Furthermore, macrophages from Notch1(+/-) mice had decreased expression of VEGFR-1 compared with macrophages from wild-type mice, whereas VEGFR-1 expression in Notch4(-/-) macrophages was normal. Inhibition of Notch signaling decreased induction of the inflammatory cytokines IL-6, IL-12, CXCL10, MCP-1, monokine induced by IFN-γ, and TNF-α in macrophages in response to LPS/IFN-γ. Additionally, macrophages from Notch1(+/-) mice demonstrated decreased induction of IL-6, IL-12, and TNF-α in response to stimulation compared with wild-type mice. Thus, both pharmacological inhibition of Notch and genetic analysis demonstrate that Notch1 regulates VEGFR-1 and cytokine expression in macrophages. We have also established that Notch1 is important for the inflammatory response during wound healing in mice.
Wild-type p53 gene expression induces granulocytic differentiation of HL-60 cells (1994)

Overexpression of wild-type p53 gene in malignant cell lines has been shown to inhibit cell proliferation in a number of cases. However, endogenous p53 protein seems to play little role in normal cell-cycle control as suggested by the normal development of p53 null mice, and by the low p53 protein levels expressed in most cell types. Recently, increased expression of endogenous p53 protein has been observed during the cellular response to DNA damage, as well as during differentiation of human hematopoietic cells. To study the role of the p53 gene in hematopoietic differentiation, we introduced the wild-type p53 gene or the temperature-sensitive p53(Val135) mutant into p53-deficient HL-60 promyelocytic leukemia cells. Morphological analysis, flow-cytometric determination of granulocytic or monocytic surface markers, and ability to reduce nitroblue tetrazolium (NBT) demonstrated that expression of exogenous wild-type p53 gene in HL-60 cells induces differentiation through the granulocytic pathway. Proliferation and cell-cycle analysis performed early after expression of wild-type p53 showed that induction of differentiation is not coupled with growth arrest, which suggests that p53 is involved in differentiation independently of its activity on the cell cycle.
Simulating Cardiac Fluid Dynamics in the Human Heart (2023)

Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering, and medical interest in creating mathematical models of the heart that capture, explain, and predict these fluid-structure interactions. However, existing computational models that account for interactions among the blood, the actively contracting myocardium, and the cardiac valves are limited in their abilities to predict valve performance, resolve fine-scale flow features, or use realistic descriptions of tissue biomechanics. Here we introduce and benchmark a comprehensive mathematical model of cardiac fluid dynamics in the human heart. A unique feature of our model is that it incorporates biomechanically detailed descriptions of all major cardiac structures that are calibrated using tensile tests of human tissue specimens to reflect the heart's microstructure. Further, it is the first fluid-structure interaction model of the heart that provides anatomically and physiologically detailed representations of all four cardiac valves. We demonstrate that this integrative model generates physiologic dynamics, including realistic pressure-volume loops that automatically capture isovolumetric contraction and relaxation, and predicts fine-scale flow features. None of these outputs are prescribed; instead, they emerge from interactions within our comprehensive description of cardiac physiology. Such models can serve as tools for predicting the impacts of medical devices or clinical interventions. They also can serve as platforms for mechanistic studies of cardiac pathophysiology and dysfunction, including congenital defects, cardiomyopathies, and heart failure, that are difficult or impossible to perform in patients.
Closed loop control of a braided-structure continuum manipulator with hybrid actuation based on learning models (2019)

Design of continuum manipulators have always been restricted to simplified structures due to the modeling complexity involved. However with the success of machine learning based models, there are potentially more structures and actuation strategies that could be investigated. This paper presents a novel continuum manipulator with variable diameter and a general control strategy for closed loop task space control. The controller constitutes of an inverse kinematics based feedback component, a forward kinematics based feedforward component and a low level velocity controller. Our findings indicate how such an approach can deal with singularities and provide smooth and accurate motion.
Effect of Polymorphic Transformation During the Extrusion-Granulation Process on the Pharmaceutical Properties of Carbamazepine Granules. (1997)

The effects of a solvent system on the pharmaceutical properties of carbamazepine (CBZ) granules containing a polymorphic form of bulk powder were investigated by X-ray diffraction analysis, thermal analysis, mercury porosimetry and Brunauer-Emmett-Teller (BET) surface area measurement. A powder mixture consisting of 20% CBZ form I, as a bulk powder, 56% crystalline α-lactose monohydrate and 24% corn starch was used as a pharmaceutical powder, with the three kinds of binder solutions (distilled water, 50% aqueous ethanol and ethanol) containing 5% hydroxypropylcellulose (HPC). After kneading with a binder solution, the granules were obtained using an extruding granulator. The X-ray diffraction and differential scanning calorimetry (DSC) results of the granules indicated that form I with 50% ethanol solution transformed into a dihydrate form during extruding granulation, but this did not occur with the distilled water or ethanol solutions. The order of hardness and specific surface area (Sw) of the granules was distilled water>50% ethanol>ethanol and 50% ethanol>ethanol>distilled water. The stress-thickness profiles of the tabletting compression processes of CBZ granules obtained using various binder solution systems were measured, and the initial compression process due to particle rearrangement was affected by the characteristics in the granules. The total pore volume of tablets obtained from 50% ethanol was the lowest, and their order was ethanol>distilled water>50% ethanol. Their order of tablet hardness reflected the total pore volume of the tablet, and was 50% ethanol>distilled water>ethanol. All pharmaceutical properties of the granules and/or tablets containing CBZ were affected by the characteristics of the solvent systems in binder solution.
Topological analysis of electron density distribution taken from a pseudopotential calculation (1997)

Theoretical studies of the electron density topology at the bond critical point for some small molecules, Ti, and Mo organometallic complexes were undertaken in order to understand the reason for the failure of the topological analysis of the coreless electron densities obtained from a pseudopotential calculation. We show that the absence of the core electron density is the main reason for such behavior. The erratic behavior of the effective core potentials electron densities can be corrected by adding atomic electron core density obtained from a single-atom Hartree-Fock calculation. The effect of orthogonalization of the core orbital with the valence orbitals was also investigated. © 1997 by John Wiley & Sons, Inc.
Local phonon analysis in InGaN film by mapping of Raman peak energy (2019)

Since heat generation in electronic devices induces the degradation of performance, the understanding of their thermal properties is required. InGaN and AlInN alloys are possibly the key materials for optical devices in green gap and high power transistors. Characteristic properties of local strain, fluctuation of energy gap, carrier dynamics, and so forth due to spatial nonuniformity of alloy composition are now under investigation, while nonuniform thermal conduction remains unclear. In this report we show nonuniform heat or phonon conductance in the nonuniform field of InGaN alloy composition. An In <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.16</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.84</sub> N (110nm) film grown on GaN grown on a sapphire substrate was characterized by micro Raman spectroscopy with controlling spot positions of two color lasers: 325nm for electronic excitation and phonon generation and 532nm for Raman probe. Thermal properties were analyzed by two-dimensional mapping of Raman signal by 532 nm line and its energy shift by introducing the 325nm line. It is found that the phonon transport mainly takes place along the region with low GaN mole fraction or low phonon energy, while some of phonons are transported through narrow regions with higher GaN mole fraction. This pump and probe Raman method gives us phonon transport properties in semiconductors.
ChemInform Abstract: Synthesis of Chiral Building Blocks and Biologically Active Compounds from D‐Glucosamine. Part 1. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Impact of Electric Vehicles on Low Voltage Grids: A Case Study of Berlin (2018)

Replacing fossil-fueled vehicles with electric vehicles (EVs) poses new challenges for public distribution networks. In order to accommodate these new loads in current grid extension planning, distribution system operators (DSOs) have to consider various EV penetration scenarios. This involves long planning and investment cycles, on the one hand, and several dissemination projections on the other. In this case study, the potential impact of EVs on transformer, cable sections and power quality in two representative urban and suburban low-voltage (LV) grids are investigated. For that, simulation studies based on real grid topologies are employed. Two different approaches to modelling EV charging concurrency behavior in the urban and suburban grids are applied. The study finds that when concurrency in charging is considered and EVs comply with harmonics regulation standards, Berlin's LV grids can accomodate very high penetrations of even 50% and 100% without the need for reinforcement. Penetrations below 30%, however, may lead to overloading or unacceptable power quality. This may occur if EVs do not comply with current standards or mobility and charging patterns deviate significantly from the proposed approaches.
A Novel Automated Design Methodology for Power Electronics Converters (2021)

This work proposes a methodology for designing power electronic converters called “Automatic Design for Manufacturing” (ADFM). This methodology proposes creating Power Converter Arrays (PCAs) using standardized converter cells. The approach is greatly inspired by the microelectronics integrated circuit design flow, power electronics building blocks, and multicell converters. To achieve the desired voltage/current specifications, the PCA conversion stage is made from the assembly of several Conversion-Standard Cells (CSCs) in series and/or parallel. The ADFM uses data-based models to simulate the behavior of a PCA with very little computational effort. These models require a special characterization approach to maximize the amount of knowledge while minimizing the amount of data. This approach consists of establishing an experiment plan to select the relevant measurements that contain the most information about the PCA technology, building an experimental setup that is capable of acquiring data automatically and using statistical learning to train models that can yield precise predictions. This work performed over 210 h of tests in nine different PCAs in order to gather data to the statistical models. The models predict the efficiency and converter temperature of several PCAs, and the accuracy is compared with real measurements. Finally, the models are employed to compare the performance of PCAs in a specific battery charging application.
Use of a Catalytic Chiral Leaving Group for Asymmetric Substitutions at sp3‐Hybridized Carbon Atoms: Kinetic Resolution of β‐Amino Alcohols by p‐Methoxybenzylation (2016)

Abstract A catalytic strategy was developed for asymmetric substitution reactions at sp 3 ‐hybridized carbon atoms by using a chiral alkylating agent generated in situ from trichloroacetimidate and a chiral phosphoric acid. The resulting chiral p ‐methoxybenzyl phosphate selectively reacts with β‐amino alcohols rather than those without a β‐NH functionality. The use of an electronically and sterically tuned chiral phosphoric acid enables the kinetic resolution of amino alcohols through p ‐methoxybenzylation with good enantioselectivity.
Mechanical left ventricular unloading during high risk coronary angioplasty: First use of a new percutaneous transvalvular left ventricular assist device (1994)

A new catheter mounted, transvalvular left ventricular assist device has been designed for percutaneous transfemoral access. The device, the Hemopump [14 French (Fr.) outer diameter], is based on a mixed flow rotary pump and is capable of flow rates of 1.5-2.2 l/min. The pump is inserted using a specialized 16 Fr. femoral introducer sheath. The first application of the percutaneous Hemopump in man was performed in two patients with hemodynamic compromise during high risk coronary angioplasty. In these patients, Hemopump support resulted in hemodynamic stabilization (increase in aortic pressure from 60/42 to 87/61 and from 80/60 to 100/70 mm Hg, respectively) and marked left ventricular unloading (decrease in pulmonary capillary wedge pressure from 25 to 10 and from 14 to 10 mm Hg) during balloon inflation. In both patients, percutaneous transluminal coronary angioplasty (PTCA) could be accomplished successfully. Using the system for periods of about 2 hr in each patient, we observed no vascular, hemorrhagic, or embolic complications. In both patients, only a minor increase in both plasma free hemoglobin and lactate dehydrogenase levels was noted. Our preliminary experiences suggest that the percutaneous Hemopump is safe and effective and may be a powerful alternative to other devices used for supported angioplasty.
Encodings in Legacy Khmer TrueType Fonts. Investigation and Propose of Auto-Detection Algorithm (2006)

Malgre l'utilisation croissante des normes ISO pour le codage de la plupart des ecritures indiennes dans les pays d'Asie du Sud et du Sud-Est, les codages bricoles sont encore utilises pour eviter l'implementation de systemes de mise en page complexes pour les ecritures indiennes. Puisque ces codages ne sont pas bien definis et ont ete developpes ad hoc, il est tres difficile de les detecter par des methodes deductives. Il arrive alors que l'on publie le texte le plus souvent en tant qu'image. En guise d'exemple caracteristique nous avons choisi l'ecriture cambodgienne. Nous avons examine les differentes fontes cambodgiennes diffusees gratuitement sur le Web, les codages qu'elles declarent utiliser et ceux qu'elles utilisent. Nous arrivons a la conclusion que les codages declares ne sont pas fiables. En nous basant sur les codages etudies nous proposons un algorithme heuristique de detection de codage cambodgien. Cet algorithme nous permet egalement de transcoder des documents codes dans ces codages avec une precision plus elevee que celle des methodes cognitives.
Microparticle production, neutrophil activation, and intravascular bubbles following open-water SCUBA diving (2012)

The goal of this study was to evaluate annexin V-positive microparticles (MPs) and neutrophil activation in humans following decompression from open-water SCUBA diving with the hypothesis that changes are related to intravascular bubble formation. Sixteen male volunteer divers followed a uniform profile of four daily SCUBA dives to 18 m of sea water for 47 min. Blood was obtained prior to and at 80 min following the first and fourth dives to evaluate the impact of repetitive diving, and intravascular bubbles were quantified by trans-thoracic echocardiography carried out at 20-min intervals for 2 h after each dive. MPs increased by 3.4-fold after each dive, neutrophil activation occurred as assessed by surface expression of myeloperoxidase and the CD18 component of β(2)-integrins, and there was an increased presence of the platelet-derived CD41 protein on the neutrophil surface indicating interactions with platelet membranes. Intravascular bubbles were detected in all divers. Surprisingly, significant inverse correlations were found among postdiving bubble scores and MPs, most consistently at 80 min or more after the dive on the fourth day. There were significant positive correlations between MPs and platelet-neutrophil interactions after the first dive and between platelet-neutrophil interactions and neutrophil activation documented as an elevation in β(2)-integrin expression after the fourth dive. We conclude that MPs- and neutrophil-related events in humans are consistent with findings in an animal decompression model. Whether there are causal relationships among bubbles, MPs, platelet-neutrophil interactions, and neutrophil activation remains obscure and requires additional study.