gebhart/patrepeval huggingface dataset:
Correction to Evaluation of Solution-Processable Carbon-Based Electrodes for All-Carbon Solar Cells (2013)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Evaluation of Solution-Processable Carbon-Based Electrodes for All-Carbon Solar CellsMarc P. Ramuz, Michael Vosgueritchian, Peng Wei, Chenggong Wang, Yongli Gao, Yingpeng Wu, Yongsheng Chen, and Zhenan Bao*Cite this: ACS Nano 2013, 7, 5, 4692Publication Date (Web):April 25, 2013Publication History Published online25 April 2013Published inissue 28 May 2013https://pubs.acs.org/doi/10.1021/nn401864ehttps://doi.org/10.1021/nn401864ecorrectionACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1013Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (42 KB) Get e-AlertscloseSUBJECTS:Absorption,Electrodes,Heterojunctions,Solar cells Get e-Alerts
Gastric Inhibitory Peptide Controls Adipose Insulin Sensitivity via Activation of cAMP-response Element-binding Protein and p110β Isoform of Phosphatidylinositol 3-Kinase (2011)

Gastric inhibitory peptide (GIP) is an incretin hormone secreted in response to food intake. The best known function of GIP is to enhance glucose-dependent insulin secretion from pancreatic β-cells. Extra-pancreatic effects of GIP primarily occur in adipose tissues. Here, we demonstrate that GIP increases insulin-dependent translocation of the Glut4 glucose transporter to the plasma membrane and exclusion of FoxO1 transcription factor from the nucleus in adipocytes, establishing that GIP has a general effect on insulin action in adipocytes. Stimulation of adipocytes with GIP alone has no effect on these processes. Using pharmacologic and molecular genetic approaches, we show that the effect of GIP on adipocyte insulin sensitivity requires activation of both the cAMP/protein kinase A/CREB signaling module and p110β phosphoinositol-3' kinase, establishing a novel signal transduction pathway modulating insulin action in adipocytes. This insulin-sensitizing effect is specific for GIP because isoproterenol, which elevates adipocyte cAMP and activates PKA/CREB signaling, does not affect adipocyte insulin sensitivity. The insulin-sensitizing activity points to a more central role for GIP in intestinal regulation of peripheral tissue metabolism, an emerging feature of inter-organ communication in the control of metabolism.
The Effect of Herpes Simplex Virus-1 on Nitric Oxide Synthase in the Rat Brain: The Role of Glucocorticoids (2010)

These results suggest that brain NOS activity is inhibited in the early stages of HSV-1 infection and requires the presence of circulating GCs. HSV-1-induced brain NOS inhibition may play a role in neuronal viral invasion and in the activation of the adrenocortical axis.
Synthesis of a Ti-SBA-15-NiMo Hydrodesulfurization Catalyst: The Effect of the Hydrothermal Synthesis Temperature of NiMo and Molybdenum Loading on the Catalytic Activity (2017)

We report herein the investigation of the catalytic activity on the hydrothermal synthesis temperature (HTsynT; 60–120 °C) and molybdenum loading (5–13 wt %) of NiMo catalyst supported over titanium-modified mesoporous silica (Ti-SBA-15) for the simultaneous hydrodesulfurization (HDS) of dibenzothiophene (DBT) and 4-methyldibenzothiophene (4-MDBT) in dodecane. It was found that the dispersion of an NiMo active phase in a one-pot synthesis is size-dependent and mostly controlled by the HTsynT for an efficient HDS catalytic performance. The as-developed catalysts were characterized by N2 physiosorption, X-ray diffraction (XRD), temperature-programmed techniques, and scanning electron microscopy. XRD analysis revealed that MoO3 particles agglomerate to form a high crystalline phase, as a function of the hydrothermal temperature and molybdenum loading, which, in turn, affects the textural properties, number of active sites, and reduction temperature. The catalytic performance for the simultaneous HDS of DBT and 4-MDBT was evaluated at 350 °C and 5 MPa in a batch autoclave reactor. The results show that a HTsynT of the Ti-SBA-15-NiMo catalyst above 100 °C leads to a marked decrease in the catalytic performance. The effect of the molybdenum loading on the catalytic performance was also influenced by the HTsynT. A hydrothermal temperature of 80 °C and a molybdenum loading of 8 wt % resulted in improved overall HDS activity. However, HDS by a desirable direct desulfurization route was favored over a catalyst with 13 wt % molybdenum loading.
Role of nodal signaling and the microenvironment underlying melanoma plasticity (2008)

The incidence of melanoma has increased dramatically over the last 50 yr, and although melanoma accounts for only 10% of all skin cancers, it is responsible for over 80% of skin cancer deaths. Recent studies have uncovered critical molecular events underlying melanocytic transformation and melanomagenesis. Among these noteworthy observations are the acquisition of stem cell-associated proteins, such as the Notch receptors and Nodal, which have also been implicated in melanoma progression. For example, we have demonstrated that Nodal expression is limited to invasive vertical growth phase and metastatic melanoma lesions, and that inhibition of Nodal signaling promotes the reversion of metastatic melanoma cells toward a more differentiated, less invasive non-tumorigenic phenotype. In addition, molecular cross-talk exists between the Notch and Nodal signaling pathways. Interestingly, the acquisition of stem cell-associated plasticity is often acquired via epigenetic mechanisms, and is therefore receptive to reprogramming in response to embryonic microenvironments. Here, we review the concept of melanoma plasticity, with an emphasis on the emerging role of Nodal as a regulator of melanoma tumorigenesis and progression, and present findings related to epigenetic reprogramming.
Redistribution of a rat sperm epididymal glycoprotein after in vitro and in vivo capacitation (1992)

Rat epididymal glycoprotein DE (37 kDa) associates with the sperm surface during maturation and is localized over the dorsal region of the acrosome. In the present study we examine, by indirect immunofluorescence, the localization of DE after in vitro and in vivo capacitation. While 49% of sperm capacitated in vitro for 5 hr still presented fluorescence over the dorsal region, 51% showed labeling distributed over a domain that corresponds to the equatorial segment of the sperm head. This change in the localization of fluorescence was not associated with sperm deterioration or death and increased gradually as a function of capacitation time, reaching the maximum at 5 hr. The presence of labeling over the equatorial segment results from protein migration and cannot be induced by permeabilization, proteinase, or high ionic strength treatments. The omission of Ca2+ from the standard capacitation medium inhibited the relocalization of DE, and incubation with Ca2+ ionophore A23187 for induction of the acrosome reaction (AR) significantly raised the percentage of cells with DE localized over the equatorial region. Finally, while free and cumulus-associated spermatozoa recovered from the oviducts of in vivo inseminated females presented 15% and 21% of cells with redistribution respectively, all perivitelline (acrosome reacted) spermatozoa showed DE over the equatorial segment. These results indicate that epididymal protein DE migrates to the equatorial segment under in vitro and in vivo capacitating conditions and suggest a possible association between the redistribution of DE and the occurrence of the AR.
Dendrobium Officinale Kimura et Migo Ameliorates Insulin Resistance in Rats with Diabetic Nephropathy (2018)

BACKGROUND Emerging evidence suggests the potential of Dendrobium officinale Kimura et Migo (DO) in treating the complications of diabetes mellitus (DM). We evaluated the therapeutic potential of DO in treating diabetic nephropathy (DN) by preventing insulin resistance. MATERIAL AND METHODS A DN model was established. Mean glomerular volume of rats was estimated by the method of Weibel-Gomez. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was used to determine the expression of mRNAs and we used Western blot assay to determine the expression of proteins. The levels of fasting insulin (FINS) and glucagon (GLU) were measured and we assessed the levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-a (TNF-a), and interleukin-6 (IL-6) using the enzyme-linked immunosorbent assay (ELISA). RESULTS Compared with the Normal rats, the levels of urinary glucose, albuminuria, Scr, albuminuria/Scr and BUN, and the expression levels of CaN, TLR-2, TLR-4, MyD88, hs-CRP, TNF-a, and IL-6, the level of FINS, GLU, and HOMAIR were increased in DN, DO 1.0, DO 2.0, and DMBG groups. Compared with the DN rats, in DO 1.0, DO 2.0, and DMBG groups the glomerular volume was smaller, the levels of urinary glucose, albuminuria, Scr, albuminuria/Scr, and BUN, the expression levels of CaN, TLR-2, TLR-4, MyD88, hs-CRP, TNF-a, and IL-6, the level of FINS, GLU, and HOMA-IR were decreased. CONCLUSIONS We found that DO prevents insulin resistance in rats with DN. This may be associated with reduction of TLRs and inflammatory response, which should be further verified by loss of DO effects on DN after treatment of inhibitors of TLRs.
A simple and efficient model for indoor path-loss prediction (1997)

A power-law path-loss model for indoor communications at 1.8 GHz is examined. In it, the exponent of the distance is treated as a random variable and its behaviour studied through experiments conducted under various propagation conditions in different buildings. The effects of random human traffic in the propagation channel, as well as those of antenna polarization are also experimentally studied. The statistical behaviour of the exponent and its fitting to several distribution functions, in particular Weibull, Nakagami and gamma ones, are also reported. By using the proposed model, new, simple and efficient instruments can be developed as an aid for the estimation of the power budget of indoor wireless communication systems.
Fundamentals of the Options Market (2001)

Chapter 1: Introduction to Options. Chapter 2: Characteristics of Stock Options. Chapter 3: Building Blocks. Chapter 4: Pricing Options. Chapter 5: Option Volatility. Chapter 6: Introduction to Synthetics. Chapter 7: The Greeks. Chapter 8: Position Trading. Chapter 9: Option Strategies. Chapter 10: Market Making. Chapter 11: The Marketplace. Chapter 12: Getting Started.
The inhibitors of substrate-incorporation in tumor cells. I. A screening procedure on the inhibitors of substrate-incorporation in tumor cells methodological survey and its evaluation. (1977)

A comparative study of inhibition on the substrate-incorporation in several species of tumor cells has been achieved in combination with the antibiotics having different action mechanisms. It was thus revealed that a large part of the antitumor antibiotics so far examined showed a marked inhibitory response even at a low concentration. Particularly, the antibiotics whose action mechanism were established primarily on cell membrane were markedly sensitive. An apparent difference in the sensitivity was observed in some groups of antitumor antibiotics which act on nucleic acid synthesis. A methodological survey together with an evaluation of this procedure is discussed.
Protein–Protein Interactions and Networks: Forward and Reverse Edgetics (2011)

Phenotypic variations of an organism may arise from alterations of cellular networks, ranging from the complete loss of a gene product to the specific perturbation of a single molecular interaction. In interactome networks that are modeled as nodes (macromolecules) connected by edges (interactions), these alterations can be thought of as node removal and edge-specific or "edgetic" perturbations, respectively. Here we present two complementary strategies, forward and reverse edgetics, to investigate the phenotypic outcomes of edgetic perturbations of binary protein-protein interaction networks. Both approaches are based on the yeast two-hybrid system (Y2H). The first allows the determination of the interaction profile of proteins encoded by alleles with known phenotypes to identify edgetic alleles. The second is used to directly isolate edgetic alleles for subsequent in vivo characterization.
A 24GS/s 6b ADC in 90nm CMOS (2008)

This paper presents a 24 GS/s 6 b ADC in 90 nm CMOS with the highest ENOB up to 12 GHz input frequency and lowest power consumption of 1.2 W compared to ADCs with similar performance. It uses an interleaved architecture of SAR type self-calibrating converters operating from 1 V supply combined with an array of 2.5 V T/Hs with delay, gain and offset-calibration capability.
Current Trends in Autologous Stem-Cell Transplantation for Myeloma in the Era of Novel Therapies (2011)

Since the mid 1990s, high-dose therapy followed by autologous stem-cell transplantation (ASCT) has been considered the standard of care for frontline therapy in younger patients with multiple myeloma (MM). During the past 10 years, thalidomide, bortezomib, and lenalidomide have been widely incorporated to the therapeutic armamentarium for the treatment of this disease. These agents show promise for improving the rate of complete remission both before and after ASCT without increasing toxicity. However, it is not clear whether such therapies are superior if they are used as an alternative to transplantation or whether they may reduce the need for and use of transplantation in patients in whom treatment is indicated. Therefore, the role of ASCT itself is a matter of debate: Should it be used upfront or as salvage treatment at the time of progression in patients initially treated with novel agents? This review presents current trends in ASCT for MM in the era of novel therapies.
Immunohistochemical distribution of leucocyte antigens in lymphoid tissues of cynomolgus monkeys (Macaca fascicularis) (1993)

Crossreactivity of antibodies to human leucocyte antigens with lymphoid tissues of cynomolgus monkeys was studied by immunohistochemistry and immunoblotting. Of a total of 54 clusters of differentiation (CD) antigens, 39 were expressed essentially with the same immunostaining patterns in the monkey as in human lymphoid tissues. By immunoblotting L26 (CD20) detected a 35 Kd molecule in the monkey lymph node. Our observations indicated that most of the CD antigens are expressed and can be studied in lymphoid tissues of cynomolgus monkeys.
Chemical and biological conjugation strategies for the development of multivalent protein vaccine nanoparticles (2023)

The development of subunit vaccine platforms has been of considerable interest due to their good safety profile and ability to be adapted to new antigens, compared to other vaccine typess. Nevertheless, subunit vaccines often lack sufficient immunogenicity to fully protect against infectious diseases. A wide variety of subunit vaccines have been developed to enhance antigen immunogenicity by increasing antigen multivalency, as well as stability and delivery properties, via presentation of antigens on protein nanoparticles. Increasing multivalency can be an effective approach to provide a potent humoral immune response by more strongly engaging and clustering B cell receptors (BCRs) to induce activation, as well as increased uptake by antigen presenting cells and their subsequent T cell activation. Proper orientation of antigen on protein nanoparticles is also considered a crucial factor for enhanced BCR engagement and subsequent immune responses. Therefore, various strategies have been reported to decorate highly repetitive surfaces of protein nanoparticle scaffolds with multiple copies of antigens, arrange antigens in proper orientation, or combinations thereof. In this review, we describe different chemical bioconjugation methods, approaches for genetic fusion of recombinant antigens, biological affinity tags, and enzymatic conjugation methods to effectively present antigens on the surface of protein nanoparticle vaccine scaffolds.
Hepcidin Suppression Relative to Iron Status in Patients with Chronic Hepatitis C. (2008)

Abstract Patients with chronic hepatitis C (CHC) often have increased liver iron deposits, a condition associated with reduced sustained response to antiviral therapy, more rapid progression to cirrhosis, and development of hepatocellular carcinoma. The hepatic hormone hepcidin is a major regulator of iron metabolism that inhibits iron absorption and recycling from erythrophagocytosis. Hepcidin decrease is a possible pathophysiological mechanism of iron overload in CHC, but studies in humans have been hampered so far by the lack of reliable quantitative assays for the 25-amino acid bioactive peptide in serum (s-hepcidin). Using a recently validated immunoassay (Ganz T, Blood 2008, epub Aug 8), we measured s-hepcidin levels in 82 CHC naïve patients and 57 sex-matched healthy controls with rigorous definition of normal iron status. All CHC patients underwent liver biopsy with histological iron score (according to Deugnier YM, Gastroenterology 1992). S-hepcidin was much lower in CHC than in controls (geometric means with 95% CIs: 33.7, 21.5–52.9 versus 90.9, 76.1–108.4 ng/ml, respectively; P&amp;lt;0.001), while both serum ferritin and transferrin saturation were significantly higher in CHC than in controls, as expected. S-hepcidin strongly correlated with serum ferritin in both controls (r=0.741; P&amp;lt;0.001) and CHC patients (r = 0.718; P&amp;lt;0.001). In CHC patients, s-hepcidin also correlated with histological total iron score (r = 0.46; P&amp;lt;0.001), but not with serum interleukin-6 (r = −0.042; P = n.s.). After stratification for serum ferritin quartiles, s-hepcidin levels increased significantly across quartiles in both controls and CHC patients (chi for trend, P&amp;lt;0.001). However, in the latter group s-hepcidin levels were significantly lower than in controls for each corresponding quartile (ANOVA, P&amp;lt;0.001). In the lowest ferritin quartile, s-hepcidin was significantly inversely correlated with viral loading (e.g. serum HCV-RNA IU/ml; r = −0.526; P=0.036), while this association gradually disappeared with increasing ferritin quartiles. These results, together with very recent studies in animal and cellular models (Nishina S, Gastroenterology 2008; Miura K, Hepatology 2008), indicate that though hepcidin regulation by iron stores is maintained in CHC, the suppression of this hormone by HCV is likely an important factor in liver iron accumulation in this condition.
The yeast transcriptome in aerobic and hypoxic conditions: effects of hap1, rox1, rox3 and srb10 deletions (2002)

In the paper by Becerra et al., published in Molecular Microbiology volume 43, number 3, pp. 545-555, the rox3 mutant strain used was not a deletion, lethal in the selected aGH1 background, but the rox3-182 allele with a nonsense mutation at codon 129, aGH1-rox3-182 (MATa, trp1-289, leu2-3, leu2-112, gal1Δ152, rox3-182).
<title>Growth of high-quality single crystal of KLiYF5 by TSSG method</title> (1993)

We report for the first time the growth of large size single crystals of KLiYF<SUB>5</SUB> (KLYF) by TSSG method using the conventional weight-feed-back automatic diameter control Czochralski puller. We also succeeded to grow for the first time single crystals of KLiGdF<SUB>5</SUB> (KLGF). We constructed a new pseudo-binary phase diagram for the KF-LiF-YF<SUB>3</SUB> system. Both KLYF and KLGF melt peritectically. They both showed high optical anisotropy as we expected. However, this anisotropy comes from the layer structure of the crystal which also gives a perfect set of (010) cleavage plane. At present, this is a problem preventing us to get crack-free single crystals.
Hypothyroidism following childhood cancer therapy–an under diagnosed complication (2011)

To determine the prevalence of hypothyroidism amongst most adult survivors of childhood cancer in Britain using the British Childhood Cancer Survivor Study (BCCSS). The BCCSS is a population based cohort of individuals diagnosed with childhood cancer between 1940 and 1991 and who survived at least 5 years from diagnosis (n = 17,981). 10483, 71% of those survivors aged at least 16 years, returned a completed questionnaire, which asked if hypothyroidism had been diagnosed. Of the whole cohort, 7.7% reported hypothyroidism with the highest risk among patients treated for Hodgkin's disease (HD) (19.9%), CNS neoplasms (15.3%), Non-Hodgkin's lymphoma (6.2%) and leukaemia (5.2%). Survivors were more likely to develop hypothyroidism if they had received radiotherapy for HD (p = 0.0001) or a CNS neoplasm (p < 0.00005) but not leukaemia (p = 0.3). In these three patient groups, the frequency of hypothyroidism was similar in men and women. Survivors of irradiated CNS tumours reported a prevalence of hypothyroidism, which was substantially lower if discharged to primary care compared with being on hospital follow-up and which declined substantially with increased follow-up in both primary care (p = 0.004) and hospital follow-up (p = 0.023) settings. Hypothyroidism is a common finding amongst adult survivors of childhood malignancy. The substantial differences in reported hypothyroidism prevalence after irradiated CNS neoplasms suggests substantial under-diagnosis, which increased with increased follow-up, and which increased among those followed-up in primary care compared with hospital settings.
Feedback Connections to the Lateral Geniculate Nucleus and Cortical Response Properties (1999)

The cerebral cortex receives sensory input from the periphery by means of thalamic relay nuclei, but the flow of information goes both ways. Each cortical area sends a reciprocal projection back to the thalamus. In the visual system, the synaptic relations that govern the influence of thalamic afferents on orientation selectivity in the cortex have been studied extensively. It now appears that the connectivity of the corticofugal feedback pathway is also fundamentally linked to the orientation preference of the cortical cells involved.
Condensed Calculations for Evolutionary Operation Programs (1959)

Evolutionary Operation is a method for operating plant processes. Since the method is applied by plant personnel themselves as a continuing normal part of process operation it is desirable to reduce the calculations to a simple routine matter. This paper describes calculation procedures which have been found useful in these circumstances.