gebhart/patrepeval huggingface dataset:
Tripeptide (Glutathione) Synthetase. Purification, Properties, and Mechanism of Action* (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTripeptide (Glutathione) Synthetase. Purification, Properties, and Mechanism of Action*Elizabeth Dodd Mooz and Alton MeisterCite this: Biochemistry 1967, 6, 6, 1722–1734Publication Date (Print):June 1, 1967Publication History Published online1 May 2002Published inissue 1 June 1967https://pubs.acs.org/doi/10.1021/bi00858a022https://doi.org/10.1021/bi00858a022research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Information Technology And The Inferential Gap (2007)

In medical practice, an "inferential gap" exists in two contexts: the nonapplication of relevant existing evidence, and the absence of evidence germane to a particular clinical situation. Randomized controlled trials are the current gold standard of evidence development; however, they suffer limits of generalization to the "real world." Conversely, observational studies might be more generalizable but are prone to bias, data inconsistency, and measurement error. The electronic health record offers hope for supporting the real-time presentation of information relevant to a clinical situation and serves as a platform for the conduct of large observational studies and novel quasi-experimental research.
Production of 2-amino-5-phenoxyphenol from 4-nitrobiphenyl ether using nitrobenzene nitroreductase and hydroxylaminobenzene mutase from Pseudomonas pseudoalcaligenes JS45 (2000)

Microbial metabolism of nitroarenes via o-aminophenols requires the participation of two key enzymes, a nitroreductase and an hydroxylaminobenzene mutase. The broad substrate ranges of the enzymes suggested that they could be used as biocatalysts for the production of substituted o-aminophenols. We have used enzymes from Pseudomonas pseudoalcaligenes JS45 for the conversion of 4-nitrobiphenyl ether to the corresponding o-aminophenol. Partially purified nitrobenzene nitroreductase reduced 4-nitrobiphenyl ether to the corresponding 4-hydroxylaminobiphenyl ether. Partially purified hydroxylaminobenzene mutase stoichiometrically converted the intermediate to 2amino-5-phenoxyphenol. The results indicate that the enzyme system can be applied for the production of o-aminophenols useful as intermediates for synthesis of commercially important materials.
Muon imaging and data modeling (2007)

This paper describes our novel capability for analyzing voxel data such as muon images to detect potential threat objects and then to further discriminate them by shape. This is done with Change Detection using Data Modeling. These methods minimize long exposure requirements previously reported in the literature. This paper summarizes our algorithm and provides example results.
Characteristics of p-GaAs/n-Si heterojunctions grown by molecular-beam epitaxy (1987)

We have studied the electrical characteristics of p-GaAs/n-Si heterojunction diodes grown by molecular-beam epitaxy in an effort to investigate the quality of the heterointerface. Both Ga and As prelayers were used to initiate the growth of GaAs epilayers on Si substrates. Current-voltage and capacitance-voltage measurements were made between 300 and 83 K. Ideality factors for heterojunction diodes were as good as n=2.0, despite the 4.1% lattice mismatch between Si and GaAs. At high temperatures the I-V characteristics were dominated by generation-recombination mechanisms that lead to a temperature-independent logarithmic slope with applied bias. By removing a thin layer from the Si surface, the surface leakage current was reduced by more than an order of magnitude. The measured intercept voltages, as determined by capacitance-voltage measurements, have no strong dependence on the type of prelayer used to initiate the growth of the GaAs epilayer on Si substrates. The maximum spread in measured intercept voltages was about 1 V, the absolute value of which depends upon the condition of the interface.
End‐to‐End FE‐Based Homogenization of Woven Composites (2014)

Whereas prediction of elastic properties of woven is a standard in the industry, prediction of their non-linear behavior remains a challenge. Accurate prediction of the non-linear behavior is the key for a successful modeling of woven composites solicited by off-axis loading. Woven composites are represented by interlacing yarns impregnated by a resin matrix. Yarns are made of a resin matrix reinforced by continuous fibers. Homogenization of woven composites therefore requires two levels of homogenization, the one of the yarn and the one of the ply. Finite element (FE) based homogenization at the ply level can be combined with mean-field homogenization at the yarn to predict the mechanical behavior of a single ply. The main difficulty of this approach lies in the generation of representative volume element (RVE) of a single ply. An end-to-end FE based homogenization of woven composites was developed in Digimat®. The developed set of tools allows running finite element simulations on single ply woven RVE with the use of mean-field homogenization at the yarn level. Generated RVEs are meshed with voxels to avoid meshing troubles in resin rich pockets between yarns or close to yarn crossings. The local fiber orientation used in the yarn homogenization is function of the yarn curvature. A fully analytical framework based on mean-field homogenization has also been developed. The particularity of this framework is that it takes yarn curvature into account. The developed tools will be presented and the FE based and mean-field homogenization predictions of linear and non-linear properties will be compared to experimental measurements on plain weave and 5HS carbon epoxy woven composites.
Features generation by means of currents' physical components for load identification (2015)

In this paper the process of extracting a set number of features that uniquely describe a nonlinear load is described. The method is used for classifying and identifying as well as determining the operation state of these harmonic nonlinear loads. The method is based on harmonic spectral decomposition of periodic waveforms and on sorting and calculating the features by means of Currents' Physical Components Theory. Using this theory enables to create features with physical meaning and to enable to calculate the actual various currents and powers of these loads. These features are then used in order to train an Artificial Neural Network which is used to identify and calculate the powers and currents of the identified load. The presented theory is implemented on a custom made simulator which uses simulated waveforms, as well as measured ones attained from power quality monitors.
Facilitating Access to the Field of Geometry and Reflectance Acquisition (2014)

Documentation and presentation of cultural heritage can greatly benefit from photorealistic digitization. This field, however, is subject to ongoing research and very hard to enter for new researchers. This is mostly because a respective processing pipeline requires many steps that strongly depend on each other and thus must be fully implemented. Moreover, sophisticated acquisition hardware is expensive and usually difficult to construct due to its complexity. In this paper, we briefly summarize our ongoing work in this field. Our main contribution is a collection of datasets acquired with a state-of-the-art geometry and reflectance acquisition device. The datasets do not only include the raw scanner data, but also results of our individual processing stages. Other researchers can use this data to work on a specific task/stage without having to implement the full pipeline.
A CMOS-compatible chip-to-chip 3D integration platform (2012)

In this paper, a CMOS-compatible chip-to-chip 3D integration platform will be presented. The developed technology allows reconstituting a wafer from diced and thinned chips. Then, chip-to-chip bonding and TSV fabrication steps are accomplished in wafer-level. A parylene deposition technique developed throughout this research provides a very flat wafer surface after chip embedding, thus, photoresist spin-coating and patterning can easily be performed in wafer-level. For a full-wafer exposure by a mask aligner, 5μm mask-to-chip alignment accuracy is achieved in average. In the preliminary tests, two dummy chips are successfully bonded, and TSVs with parylene sidewall passivation and electroplated Cu metallization are fabricated. The daisy-chain resistance measurements demonstrate average TSV resistance of 0.5Ω. The proposed technique introduces a simple and low-cost solution not only for 3D integration technology but also for applications involving CMOS post-processing in general, especially when the full-wafer CMOS is not affordable or not possible to post-process due to compatibility issues.
Coherent, directional supercontinuum via cascaded dispersive wave generation (2017)

We demonstrate a novel approach to producing coherent, directional supercontinuum via cascaded dispersive wave generation. By pumping in the normal group-velocity dispersion regime, pulse compression of the first dispersive wave results in the generation of a second dispersive wave, resulting in an octave-spanning supercontinuum generated primarily to one side of the pump spectrum. We theoretically investigate the dynamics and show that the generated spectrum is highly coherent. We experimentally confirm this dynamical behavior and the coherence properties in silicon nitride waveguides by performing direct detection of the carrier-envelope-offset frequency of our femtosecond pump source using an f-2f interferometer. Our technique offers a path towards a stabilized, high-power, integrated supercontinuum source with low noise and high coherence, with applications including direct comb spectroscopy.
Interleukin-1 and tumour necrosis factor production by human monocytoid cells: study on a single cell level. (1992)

Human IL-1 beta and TNF alpha production by normal and transformed monocytoid cells was studied using biological assays, cytokine specific ELISA and by immunocytochemical methods on a single cell level. Quiescent human blood monocytes and cultured in vitro transformed human monocytoid cell lines U-937, THP-1 and HL-60 did not contain IL-1 beta and TNF alpha in their cytoplasm. IL-1 beta synthesis and secretion was induced by LPS stimulation in nearly 90% monocytes, 15-20% U-937, 3-5% THP-1 and in no HL-60 cells. Normal human blood monocytes had a more rapid kinetics of IL-1 beta synthesis. IL-1 beta positive cells stained with antibodies to human IL-1 beta appeared at 1-2 hours after LPS application, while in monocytic cell lines only after 4-6 hours. Using immunoperoxidase staining of U-937 cells pulse labelled with 3H-thymidine, it was shown that proliferating cells did not synthetize IL-1 beta. Instead of IL-1 beta, TNF alpha could be induced by LPS in U-937 cells only after preliminary differentiation with PMA. Recombinant IL-1 beta induced a very low level of TNF alpha production in PMA-treated cells. Similarly recombinant TNF alpha alone induced IL-1 beta synthesis only in a few U-937 cells.
R-R Interval Outlier Processing for Heart Rate Variability Analysis using Wearable ECG Devices (2018)

Electrocardiograms (ECGs) captured by wearable ECG devices readily contain artifacts due to measurement faults. Since artifacts and R waves have quite similar frequency characteristics, R wave misdetection or R-R interval (RRI) miscalculation may result. Aiming at accurate analysis of heart rate variability (HRV), this paper proposes a new RRI outlier processing method consisting of three steps: evaluating RRI reliability, excluding RRI outlier, and complementing missing RRI. In the first step, the method evaluates the measurement status of all detected R waves and calculates RRI reliability based on the measurement status of a combination of the measurement status of two R waves. Since we target wearable ECG devices used in non-medical environment, the method evaluates R waves based on the threshold electric potential for left ventricular hypertrophy, and determines those exceeding the threshold as artifacts. The method accordingly sets lower reliability to RRIs containing R waves evaluated as artifacts. In the second step, the method excludes all RRIs with low reliability as outliers. These steps may be effective for HRV measures in the time domain, but are not sufficient for analyzing HRV measures in the frequency domain. Resampling the time series RRI data, which is essential for analyzing HRV in the frequency domain, may produce outliers if the target RRIs contain missing values. Our method accordingly complements missing RRIs before data resampling based on RRI characteristics. We postulate that consecutive changes in RRIs follow a simple formula consisting of three components: direct current, low frequency, and high frequency. Our method complements missing values according to the formula, which is calculated from RRIs time series regarded as having been properly measured. To confirm the effectiveness of the method before applying it to ECGs recorded by wearable devices, we evaluated all the steps using pseudo-ECGs generated artificially by adding noise and artifacts to open ECG data. Initial evaluation results showed that the proposed method outperformed conventional method regarding the precision of both time and frequency domain measures of HRV.
Scalable real-time parallel garbage collection for symmetric multiprocessors (2001)

Garbage collection or automatic memory reclamation frees the programmer from the tedious and often error-prone task of memory deallocation. Since its incorporation into LISP in 1970, it has proved popular among high-level and safe programming languages such as Perl, ML, and Java. Due to the disruption of collection on the application, past efforts have concentrated on bounding application pause times by collecting incrementally or by using a multiprocessor. However, these sometimes successful collectors are not suitable for providing both scalable parallelism and real-time response at the same time. 
This thesis describes the first parallel, real-time garbage collection algorithm. Using an abstract symmetric multiprocessor model, we prove space and time bounds guaranteeing that every application pause is constant and that the collector takes bounded space. The possibility of multiple collector and application threads executing simultaneously requires careful synchronization to preserve correctness. To achieve real-time bounds, large objects must be copied incrementally and particular attention must be paid to turning the collector on and off. Finally, load-balancing using a scalable stack or queue provides good parallelism. 
In order to make the algorithm practical for incorporation into a runtime system, two types of changes are necessary. First, most compilers require a richer interface including stacks and global variables. Also, we must eliminate certain constructs in the abstract model that have no obvious translation. The difficulty in these modifications lies in preserving the other properties of the collector. Second, algorithmic changes for improving performance were adopted. These modifications reduce collection overhead and memory consumption. 
The resulting algorithm has been implemented in the context of the TILT/SML compiler. Using a set of 15 benchmarks, the collector was tested on an Enterprise 10K. In the 5 ms range, the collector is able to always provide the application with 15% to 35% access to the processor even when the collector is on. As for scalability, the collector gives a speedup of 24 to 29 when running with 32 processors. The collector's speedup is, in all cases, greater than that of the application.
Impact of Adjuvant Chemotherapy on Survival of Patients with Advanced Residual Disease at Radical Cystectomy following Neoadjuvant Chemotherapy: Systematic Review and Meta-Analysis (2021)

The administration of AC in patients with MIBC and pT3-T4 residual disease after NAC might have a positive impact on OS and DSS. However, this may not apply to N+ patients.
A Parametric Study of the Seismic Margins of Piping Components (2002)

This paper presents an analytical study of frequency effects on seismic margins of piping components. The study is based on response data obtained as part of a joint Electric Power Research Institute (EPRI) and NRC Piping and Fitting Dynamic Reliability (PFDR) Program. The majority of the PFDR component tests were performed using a narrow-banded earthquake excitation input that was tuned to have a frequency slightly lower than the fundamental frequency of the test components. However, the natural frequency of a piping system in an actual plant may vary over a wide range. Therefore the seismic margins at off-resonance conditions are of importance. Two seismic margin definitions are examined. The primary objective of this study was to extrapolate the PFDR test margins to other frequency regions and to investigate the effects of various parameter changes on the margins.
ChemInform Abstract: A Versatile Method for the Synthesis of (S)‐ or (R)‐Cycloalkylglycines, (S)‐ or (R)‐N‐Heterocyclic and α,β‐Unsaturated N‐ Heterocyclic α‐Amino Acids. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Consistent effects of nitrogen fertilization on soil bacterial communities in contrasting systems (2010)

Ecosystems worldwide are receiving increasing amounts of reactive nitrogen (N) through anthropogenic activities. Although the effects of increased N inputs on plant communities have been reasonably well studied, few comparable studies have examined impacts on whole soil bacterial communities, though they play critical roles in ecosystem functioning. We sampled soils from two long-term ecological research (LTER) experimental N gradients, both of which have been amended with NH4NO3; a grassland at Cedar Creek (27 years of N additions) and an agricultural field at Kellogg Biological Station (8 years of N additions). By examining shifts in bacterial communities across these contrasting ecosystem types, we could test competing hypotheses about the direct and indirect factors that might drive bacterial responses to elevated N inputs. Bacterial community structure was highly responsive to N additions. We observed predictable and consistent changes in the structure of the bacterial communities across both ecosystem types. Our results suggest that bacterial communities across these gradients are more structured by N and/or soil carbon availability than by shifts in the plant community or soil pH associated with the elevated nitrogen inputs. In contrast to the pronounced shifts in bacterial community composition and in direct contrast to the patterns often observed in plant communities, increases in N availability did not have consistent effects on the richness and diversity of soil bacterial communities.
Predictive factors for positive disco-vertebral biopsy culture in pyogenic vertebral osteomyelitis, and impact of fluoroscopic versus scanographic guidance (2020)

Every patient with PVO and negative blood cultures should undergo a DVB. A thickening of the paravertebral tissue ≥10 mm on MRI is associated with a higher rate of positive DVB culture. A lumbar DVB under fluoroscopic guidance is more sensitive than under scanographic guidance to identify the micro-organism involved.
Highly-Reliable Low-Resistance Cu Interconnects with PVD-Ru/Ti Barrier Metal toward Automotive LSIs (2008)

Highly-reliable Cu interconnects with Ru/Ti barrier metal have been developed, in which Ti is diffused into the Ru-layer to establish a Cu-diffusion barrier. The PVD-Ru/Ti barrier metal with preferable crystal-orientation to Cu texture achieves the low line resistance. The Ti-doping in the Cu grain boundary just under the via improves the Cu-via reliabilities, besides keeping the Cu line resistance low. The Cu line with the Ru/Ti barrier metal is a strong candidate for automotive LSIs in future, requiring high performance and ultra-high reliability.
Increased growth of NIH/3T3 cells by transfection with human p120 complementary DNA and inhibition by a p120 antisense construct. (1992)

The human nucleolar antigen p120 was detected with an anti-p120 monoclonal antibody in most human malignant tumors but not in most resting human tissues (J. W. Freeman et al., Cancer Res., 48: 1244-1251, 1988) and has been used as a prognostic tumor marker in breast cancer patients (J. W. Freeman et al., Cancer Res., 51: 1973-1978, 1991). After the complementary DNA and gene for the human p120 protein were isolated and sequenced (review: H. Busch, Cancer Res., 50: 4830-4838, 1990), constructs were prepared to study the expression of the sense p120 and its antisense, p021 message. NIH/3T3 cells were transfected by electroporation with pSVX plasmids containing either the p120 complementary DNA (pSVX120) or the antisense, p021 DNA (pSVX021), and clones containing these constructs were selected. The expression of p120 or p021 in these constructs was regulated by Moloney murine leukemia virus long terminal repeats. In pSVX120-transfected NIH/3T3 cells, the expressed human p120 protein was localized to the nucleoli as shown by anti-p120 monoclonal antibody immunofluorescence. Expression of the p120 message and protein was confirmed by Northern (mRNA) and Western (protein) blots. Transfection of the p120 complementary DNA in sense orientation caused malignant transformation of NIH/3T3 cells in vitro and produced rapidly growing tumors in nude mice. Transfection of the antisense p120 constructs markedly delayed the growth of these tumors in vitro and in vivo (L. Perlaky et al., Proc. Am. Assoc. Cancer Res., 32: 1682, 1991). When transformed 3T3/pSVX120 cells were transfected with an inducible antisense p120 construct (pMSG021), dexamethasone induction decreased the growth rate by 62%, and the cell line returned to its normal phenotype. Northern blot analysis showed a decreased level of p120 mRNA, and the immunofluorescence was also markedly reduced.