gebhart/patrepeval huggingface dataset:
Adsorption of Contaminants of Emerging Concern from Aqueous Solutions using Cu2+ Amino Grafted SBA-15 Mesoporous Silica: Multicomponent and Metabolites Adsorption (2018)

SBA-15 and Cu2+ amino grafted SBA-15 adsorbents (CuNH2_g_SBA-15) were prepared to investigate the equilibrium and dynamic adsorptive removal of a set of contaminants of emerging concern (CECs; carbamazepine, caffeine, clofibric acid, salicylic acid, and naproxen) from water. Multicomponent and CEC metabolites adsorption was also evaluated to elucidate effects on adsorption capacity and selectivity. Equilibrium adsorption studies showed that CuNH2_g_SBA-15 is capable of removing anionic and acidic CECs even at trace level concentrations. However, multicomponent tests revealed a decrease of 30% in adsorption capacity in the case of the acids. The CuNH2_g_SBA-15 variant was less affected by multicomponent competitive adsorption, probably due to the ability of this adsorbent to interact with CECs through several, simultaneous adsorption mechanisms (i.e., electrostatic interaction, hydrogen bonds, and metal coordination complexes). These were confirmed via X-ray photoelectron spectroscopy (XPS) analyses. Preliminary fixed-bed adsorption tests showed that beds made of CuNH2_g_SBA-15 are prone to mass-transfer resistance in comparison to those made of unmodified SBA-15, causing a decrease in both adsorption capacity and degree of bed utilization. Adsorption of parent/metabolites CEC binary mixtures resulted in a reduction in adsorption capacity of the parent CECs, but the adsorbents showed a remarkable selectivity toward the metabolites, particularly CuNH2_g_SBA-15. In general, this study provides substantial evidence that the anchoring of amine/copper species onto the surface of mesoporous silica may provide a platform for the development of CEC selective adsorbents for water treatment.
Vaspin – a link of obesity and psoriasis? (2012)

Psoriasis is an inflammatory skin disease often associated with obesity. The anti-inflammatory adipokine vaspin, a suggested serine proteinase inhibitor of the serpin family, is discussed as a new link between inflammation and obesity. Here, we demonstrate that - different from healthy controls - vaspin serum levels in patients with psoriasis were body mass index independent. Moreover, we could identify keratinocytes as the major source of vaspin in skin. Vaspin expression in lesional psoriatic skin was reduced compared with uninvolved skin as shown by immunohistochemistry and RT-PCR. In aggregate, we report on the cellular source of vaspin in skin and its expression in psoriasis.
Dependence of oxide thickness on O2 pressure and experimental determination of Gibbs free energies of ultrathin oxide films in vacuum (2004)

Ultrathin oxide films grown in a vacuum are important in many industrial processes, with the values of Gibbs free energies of the gas and films determining the oxide type that grows on a surface, and its thickness. A high-stability quartz-crystal microbalance is used to provide quantitative experimental data on these free energies, for the model case of oxidation of a lead film on a gold substrate. The surface oxide, PbO, forms a single molecular layer at 10−6Torr of O2, but thickens abruptly to two layers at 1×10−4Torr, and becomes even thicker by 0.33Torr. This is explained using film free energies.
229: Sexual Function in Ethnically Diverse Men with Category III Prostatitis / Chronic Pelvic Pain Syndrome (2004)

You have accessJournal of UrologyPodium, Saturday, May 8, 2004, 3:30 - 5:30 pm1 Apr 2004229: Sexual Function in Ethnically Diverse Men with Category III Prostatitis / Chronic Pelvic Pain Syndrome Zeph Okeke, Konstantin Walmsley, Alexis E. Te, and Steven A. Kaplan Zeph OkekeZeph Okeke More articles by this author , Konstantin WalmsleyKonstantin Walmsley More articles by this author , Alexis E. TeAlexis E. Te More articles by this author , and Steven A. KaplanSteven A. Kaplan More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)37491-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "229: Sexual Function in Ethnically Diverse Men with Category III Prostatitis / Chronic Pelvic Pain Syndrome." The Journal of Urology, 171(4S), p. 60 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 60 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Zeph Okeke More articles by this author Konstantin Walmsley More articles by this author Alexis E. Te More articles by this author Steven A. Kaplan More articles by this author Expand All Advertisement PDF downloadLoading ...
A minimum variance unbiased estimator for resolving blurred beamformed images corrupted by signal-dependent speckle noise (1995)

A variety of methods currently exist for resolving the ambiguity and blurring introduced by beamforming ocean acoustic line array measurements of ambient noise [R. A Wagstaff, J. Acoust. Soc. Am. 63, 863–869 (1978)] and reverberation [N. C. Makris, J. Acoust. Soc. Am. 94, 983–993 (1993)]. However, these methods are not necessarily optimal because they assume that the measured data are deterministic, whereas in actuality they are stochastic. An optimal estimator for resolving such blurred beamformed images produces the minimum variance possible and is unbiased in its output. Estimation theory is used to derive such a minimum variance unbiased (MVU) estimator and to determine bounds on the resolution of such blurred images. The fields measured by the array are assumed to obey circular complex Gaussian random (CCGR) statistics, which have previously been shown to describe a wide variety of ocean acoustic field measurements from towed-array reverberation, to both horizontal and vertical ambient noise. Given CCGR fields, the resulting beamformed images are corrupted with signal-dependent noise known as speckle. Coherence theory for CCGR fields is used to express the MVU estimator for resolving blurred images in terms of the temporal coherence of the received fields and the measurement time.
Molecular Genotyping of Human Papillomavirus L1 Gene in Low-Risk and High-Risk Populations in Bangkok (2015)

High- and low-risk HPV genotypes persist in high-risk groups in Bangkok. Some genotypes infecting at-risk populations are not vaccine preventable. These findings may help to elucidate the prevalence of HPV infections in Thailand and serve as the basis for additional investigations into risk factors for these populations.
The relationship between neuron-specific enolase and prognosis of patients with acute traumatic brain injury (2015)

<strong>Objective</strong> To investigate the relationship between neuron-specific enolase (NSE) levels in serum and cerebrospinal fluid (CSF) of patients with acute traumatic brain injury (TBI) and the prognosis of TBI patients. <strong>Methods </strong> A total of 89 patients with acute TBI were divided into light, medium, heavy and severe TBI groups based on admission Glasgow Coma Scale (GCS) score. Serum NSE expression levels were detected in all cases and NSE levels in CSF were detected in 18 cases within 12 h after TBI. The expression levels of serum NSE in 20 normal people, except cases of lung disease and nervous system damage, were detected as a control group. <strong>Results</strong> Compared with the control group, serum NSE expression levels of patients in each TBI group were elevated (<em>P</em> &lt; 0.05, for all), and the NSE levels in severe and heavy TBI groups were higher than that in medium and light groups (<em>P</em> &lt; 0.05, for all). The serum NSE expression levels of patients with cerebral contusion were higher than that of patients with diffuse axonal injury (DAI, <em>P</em> = 0.025), subdural hematoma (<em>P</em> = 0.031) and epidural hematoma (<em>P</em> = 0.021). Serum NSE expression levels were negatively correlated with GCS score (<em>r<sub>s</sub></em> = - 0.327, <em>P</em> = 0.024) and Glasgow Outcome Scale (GOS) score (<em>r<sub>s</sub></em> = - 0.252, <em>P</em> = 0.049). The NSE expression levels of CSF in severe and heavy TBI patients were higher than that of serum (<em>P</em> = 0.039, 0.031). <strong>Conclusions</strong> NSE expression changes can be evaluated as an auxiliary indicator in reflecting the degree of acute TBI, typing diagnosis and prognostic evaluation, and NSE levels of CSF is more sensitive than that of serum. <strong>DOI: </strong>10.3969/j.issn.1672-6731.2015.03.013
Advanced Free Flight Planner and Dispatcher's Workstation: Preliminary Design Specification (1997)

The National Aeronautics and Space Administration (NASA) has implemented the Advanced Air Transportation Technology (AATT) program to investigate future improvements to the national and international air traffic management systems. This research, as part of the AATT program, developed preliminary design requirements for an advanced Airline Operations Control (AOC) dispatcher's workstation, with emphasis on flight planning. This design will support the implementation of an experimental workstation in NASA laboratories that would emulate AOC dispatch operations. The work developed an airline flight plan data base and specified requirements for: a computer tool for generation and evaluation of free flight, user preferred trajectories (UPT); the kernel of an advanced flight planning system to be incorporated into the UPT-generation tool; and an AOC workstation to house the UPT-generation tool and to provide a real-time testing environment. A prototype for the advanced flight plan optimization kernel was developed and demonstrated. The flight planner uses dynamic programming to search a four-dimensional wind and temperature grid to identify the optimal route, altitude and speed for successive segments of a flight. An iterative process is employed in which a series of trajectories are successively refined until the LTPT is identified. The flight planner is designed to function in the current operational environment as well as in free flight. The free flight environment would enable greater flexibility in UPT selection based on alleviation of current procedural constraints. The prototype also takes advantage of advanced computer processing capabilities to implement more powerful optimization routines than would be possible with older computer systems.
Twice-weekly intravenous treatment of pancreatic cancer with atrial natriuretic peptide and vessel dilator. (2010)

Biweekly vessel dilator and ANP both eliminate some human pancreatic adenocarcinomas in athymic mice.
A Query Language for EER Schemas. (1994)

We present a proposed query language for extended entity relationship schemas. The language improves on previous proposals by using only concepts explicitly in a given schema. It includes quantifiers and aggregates to allow complex queries to be expressed, and it allows derived subtypes, attributes and relationships to be defined and used in queries. Further extensions are discussed. 1
Probes for Photoaffinity Labelling of Kinases (2021)

Protein kinases, one of the largest enzyme superfamilies, regulate many physiological and pathological processes. They are drug targets for multiple human diseases, including various cancer types. Probes for the photoaffinity labelling of kinases are important research tools for the study of members of this enzyme superfamily. In this review, we discuss the design principles of these probes, which are mainly derived from inhibitors targeting the ATP pocket. Overall, insights from crystal structures guide the placement of photoreactive groups and detection tags. This has resulted in a wide variety of probes, of which we provide a comprehensive overview. We also discuss several areas of application of these probes, including the identification of targets and off-targets of kinase inhibitors, mapping of their binding sites, the development of inhibitor screening assays, the imaging of kinases, and identification of protein binding partners.
Understanding allosteric interactions in hMLKL protein that modulate necroptosis and its inhibition (2019)

Mixed Lineage Kinase domain-Like (MLKL), a key player in necroptosis, is a multi-domain protein with an N-terminal 4 helical bundle (4HB) and a pseudokinase domain (PsK) connected by brace helices. Phosphorylation of PsK domain of MLKL is a key step towards oligomerization of 4HB domain that causes cell death. Necrosulfonamide (NSA) binds to the 4HB domain of MLKL to inhibit necroptosis. To understand the molecular details of MLKL function and it's inhibition, we have performed a molecular dynamic study on hMLKL protein in apo, phosphorylated and NSA-bound states for a total 3 μs simulation time. Our simulations show increased inter-domain flexibility, increased rigidification of the activation loop and increased alpha helical content in the brace helix region revealing a form of monomeric hMLKL necessary for oligomerization upon phosphorylation as compared to apo state. NSA binding disrupts this activated form and causes two main effects on hMLKL conformation: (1) locking of the relative orientation of 4HB and PsK domains by the formation of several new interactions and (2) prevention of key 4HB residues to participate in cross-linking for oligomer formation. This new understanding of the effect of hMLKL conformations on phosphorylation and NSA binding suggest new avenues for designing effective allosteric inhibitors of hMLKL.
A nonrecursive signal integrator using a parallel CCD structure (1979)

In view of its advantages in certain situations over a recursive arrangement, the CCD implementation of a nonrecursive integrator is considered. Transfer inefficiency effects make it virtually essential to adopt a parallel-transfer approach. An implementation is proposed which requires only commercially available CCD delay lines together with conventional analog and digital techniques for driving and addressing the CCDs. An experimental simulation has established the feasibility of this approach. Investigations of the distortion inherent in one version of the integrator and of the integration improvement attainable are in good agreement with theory.
Synthesis and Crystal Structure of [Ni(H2O)6][Ni(H2O)2(C4H2O4)]·4H2O (2003)

Reaction of a freshly prepared Ni(OH)2−2 x (CO3) x ·yH2O with maleic acid in H2O at room temperature afforded [Ni(H2O)6][Ni(H2O)2(C4H2O4)]·4H2O, which consists of [Ni(H2O)6]2+ cations, [Ni(H2O)2(C4H2O4)]2− anions and lattice H2O molecules. Ni atoms in cations are octahedrally coordinated and Ni atoms in anions are each octahedrally coordinated by bidentate chelating maleato ligands and two water molecules at trans positions. Cations and anions are interlinked by hydrogen bonds to form 1D chains, which are hexagonally arranged and connected by the lattice water molecules. When heated in a flowing argon stream, the compound decomposes, with complete dehydration being followed by dissociation of nickel maleate into NiO and maleic anhydride.
Curli Temper Adherence of Escherichia coli O157:H7 to Squamous Epithelial Cells from the Bovine Recto-Anal Junction in a Strain-Dependent Manner (2016)

This study demonstrated that O157 strains interact with epithelial cells in a host-specific manner. The fimbriae/adhesins that are significant for adherence to human cell lines may not have a role or may have a modulating role in O157 adherence to bovine cells. Targeting such adhesins may not prevent O157 attachment to bovine cells but instead may result in improved adherence. Hence, conducting host-specific evaluations is critical when selecting targets for O157 control strategies.
Impulse Generation Mechanisms in a Laser-Driven In-Tube Accelerator (2008)

To enhance laser-propulsion thrust performance, a unique Laser-driven In-Tube Accelerator (LITA) has been developed. This paper numerically analyzes the impulse generation mechanisms in LITA. For this purpose, a LITA performance experiment was conducted in atmospheric air with a projectile installed on a ballistic pendulum to calibrate the numerical approximations. We conducted experimental flow visualization by framing shadowgraph and computational fluid dynamics solving the axi-symmetric Euler equation applied to an ideal gas. The results show that a laser-driven blast wave is generated by a spherical hot gas core where the supplied laser energy is absorbed first. The effect of confinement by the tube or shroud wall is confirmed. The impulse production is established not only from the interaction between the incident blast wave and projectile, but also from the following repetitive pressure waves. Assuming that about 30% of the input laser energy is absorbed by the working air, both the impulse and peak pressure agrees quantitatively between the experiment and numerical simulation.
Performance Improvement of High Power High Efficiency AlGaN/GaN HEMT based on the Process Design of Experiment Approach (2008)

Ultimately, the transistor power performance parameters depend on initial epitaxial material characteristics, device geometry and process parameters. This work presents a systematic research based on the design of experiment (DoE) approach by using minimal number of wafers. Factors of the DoE were few crucial process steps and process flow sequence. Different ohmic contacts alloying ambience, variation of surface treatment before SiN passivation and different sequence of the SiN passivation step in the process flow were evaluated. The optimal process flow was realized on 3&amp;quot; wafers. Pout of 6 W/mm, PAE 70 % and 15dB gain at S-band for 0.2 mm device was measured at 30 V VD that is good aligned with state-of-the art results [3].
ChemInform Abstract: SOLUTION PHOTOCHEMISTRY OF 4‐ALKYLIDENE‐3,3,5,5‐TETRAMETHYL‐Δ1‐PYRAZOLINES (1983)

Abstract Zur Untersuchung der Struktur des Biradikals Trimethylenmethan wird die Photolyse der Titelverbindungen (I) durchgeführt.
Steady states and global dynamics of electrical activity in the cerebral cortex (1998)

Steady states and global dynamics of electrical activity in the cerebral cortex are investigated within the framework of a recent continuum model. It is shown that for a particular physiologically realistic class of models, at most three steady states can occur, two of which are stable. The global dynamics of spatially uniform activity states is studied and it is shown that in a physiologically realistic class of models, the adiabatic dynamics is governed by a second-order differential equation equivalent to that for the motion of a Newtonian particle in a potential in the presence of friction. This result is used to derive a simplified dynamical equation in the friction-dominated limit. Solutions of these equations are compared with those of the full global dynamics equations and it is found that they are adequate for time scales longer than approximately 100 ms provided dendritic integration times are less than approximately 10 ms.
Pattern-Reversal Visual Evoked Potential on Smart Glasses (2019)

The proposed device leads the way for a portable and low-cost solution.
Highly dispersive nature of photonic-band-gap waveguides (2003)

Summary from only given. We obtained excellent agreement between the experimental results and the 3D FDTD calculation. The experimentally-determined dispersion curve is shown by solid dots in the figure. The result directly shows that we can quantitatively design the group dispersion of light waveguides with a great degree of freedom, which is promising for various application of photonic band gap waveguides.
Glutathione metabolism in primate lenses: A phylogenetic study of glutathione synthesis and glutathione redox cycle enzyme activities (1994)

Lens wet weights, soluble protein, and activities of γ-glutiamylcysteine synthetase, glutathione synthetase, glutathione peroxidase, and glutathione reductase were determined in primate lenses. The primary sources of lenses were middle-aged adult animals. The Primates, from 23 genera, were categorized into six superfamilies: hominoids (five species), Old World monkeys (seven species), New World monkeys (five species), tarsiers (two species), lemurs (six species), and lorisids (three species). Significant differences between various groups or combinations of groups were noted for γ-glutamylcysteine synthetase, glutathione peroxidase, and glutathione reductase activities. Lenticular γ-glutamylcysteine synthetase activity was very low in the Old World simian lenses and highest in the prosimians. Glutathione peroxidase activity was extraordinarily high in lenses of Old World monkeys. Glutathione reductase activity was low in all the prosimians but tenfold higher in hominoid lenses with intermediate values in monkeys of both the Old World and New World. Glutathione synthetase activity was variable, and no clear pattern which might be useful for primate classification was noted. Lenticular activity ratios of glutathione synthetase:γ-glutamylcysteine synthetase were highest in the Old World simians and lowest in the prosimians. These data with emphasis upon Aotus and the tarsiers were examined with regard to phylogenetic relationships. © 1994 Wiley-Liss, Inc.
Tensor Deep Stacking Networks (2013)

A novel deep architecture, the tensor deep stacking network (T-DSN), is presented. The T-DSN consists of multiple, stacked blocks, where each block contains a bilinear mapping from two hidden layers to the output layer, using a weight tensor to incorporate higher order statistics of the hidden binary (½0; 1) features. A learning algorithm for the T-DSN’s weight matrices and tensors is developed and described in which the main parameter estimation burden is shifted to a convex subproblem with a closed-form solution. Using an efficient and scalable parallel implementation for CPU clusters, we train sets of T-DSNs in three popular tasks in increasing order of the data size: handwritten digit recognition using MNIST (60k), isolated state/phone classification and continuous phone recognition using TIMIT (1.1 m), and isolated phone classification using WSJ0 (5.2 m). Experimental results in all three tasks demonstrate the effectiveness of the T-DSN and the associated learning methods in a consistent manner. In particular, a sufficient depth of the T-DSN, a symmetry in the two hidden layers structure in each T-DSN block, our model parameter learning algorithm, and a softmax layer on top of T-DSN are shown to have all contributed to the low error rates observed in the experiments for all three tasks.
The emergence of middleware in home telecommunication equipment (2001)

Cable will soon offer interactive television services. These will be joined in home networks by telephones, Internet appliances, and consumer electronic equipment. Middleware makes it possible to develop a large set of applications and to deliver them on many different hardware and software platforms. Middleware does this by providing such Web standards as HTML, ECMAScript, and Java to develop and deliver applications.