gebhart/patrepeval huggingface dataset:
Barcode Automation (BCAuto) for Los Alamos Material Control and Accountability System (2012)

The plutonium facility is actively processing material on a daily basis at LANL (4000-5000 transactions/month): (1) Physical operations, material transformations, material mixing, splitting, etc.; and (2) Electronic manipulations resulting primarily from updated NDA measurements. Improvements in efficiency and effectiveness are essential due to impacts of recent Voluntary Separation Program and the need to meet mission requirements with fewer personnel. New storage requirements (DOE M 441.1-1, Nuclear Material Packaging Manual) to protect worker safety require tracking of material and its corresponding container over long periods of time. Material at Risk tracking is essential to protect public safety and to ensure continuous operations to meet national security mission needs.
当代“马克思研究”：国家理论的新进展（续）——各种探讨、争论点和议程 (2002)

近年来，虽然人们对于那些从理论上说明国家的、具有更多的神秘色彩和抽象色彩的方式兴趣越来越小，但是，对于各种国家和国家权力的实质性研究却呈现出突破性的发展。即使对因此而出现的文献的一小部分进行回顾也是不可能的，但是，我们仍然有必要提到其中的五个论题——这五个论题促进了我们上面讨论的这些探讨的对立。
Visualizing Social Landscapes (2014)

This chapter contains sections titled: Visualizing Social Data for Social Purposes, Visualizing Social Landscapes, Postscript: The Social Paradox of Maps
Safety and Immunogenicity of a Recombinant Rabies Virus Strain (ERAG3G) in Korean Raccoon Dogs (2015)

A new alternative rabies bait vaccine strain named ERAG3G, which is applicable to wild animals, was developed to eliminate rabies in South Korea. In this study, the safety and immunogenicity of the strain was evaluated in Korean raccoon dogs. The ERAG3G was propagated in BHK/T7-9 cells. Korean raccoon dogs were administered ERAG3G (1 ml, 108.0 FAID50/ml) orally or intramuscularly to evaluate its safety and immunogenicity. The raccoon dogs were observed for 70 days after administration, and immunogenicity was measured using a fluorescent antibody virus neutralization test. The ERAG3G strain was not pathogenic to Korean raccoon dogs immunized via the intramuscular or oral route. Raccoon dogs administered the candidate vaccine via the oral route developed high virus neutralizing antibody (VNA) titers ranging from 13.7 to 41.6 IU/ ml 70 days post administration. Raccoon dogs inoculated intramuscularly with the ERAG3G strain developed moderate VNA titers ranging from 0.5 to 13.7 IU/ ml. These findings suggest that the ERAG3G strain is safe and induces a protective immune response in raccoon dogs.
Gamma-Knife Radiosurgery for Skull Base Meningiomas: Experience of Tumor Control, Clinical Course and Morbidity in a Follow-Up of More Than 8 Years (2009)

Objective: Surgical resection of skull base meningiomas is often limited due to involvement of crucial neural structures. Within the last two decades gamma-knife radiosurgery (GKRS) gained increasing importance as adjunct treatment following incomplete resection and as an alternative treatment to open surgery. However, reports of long-term results are still sparse. We therefore performed this study to analyze the long-term results of GKRS treatment of skull base meningiomas, following our previously published early follow-up experience.
Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA‐A24‐positive pancreatic adenocarcinoma (2019)

The prognosis of advanced pancreatic adenocarcinoma is still extremely poor. This study sought to determine the efficacy of, and immunological response to, peptide vaccination therapy in patients with this disease. In this multicenter randomized phase II study, patients with advanced pancreatic adenocarcinoma after gemcitabine and/or tegafur/gimeracil/oteracil were randomly assigned to 3 groups that each received a 2-step treatment course. In Step 1, the groups received treatments of: (i) survivin 2B peptide (SVN-2B) plus interferon-β (IFNβ); (ii) SVN-2B only; or (iii) placebo until the patients show progression. In Step 2, all patients who consented to participate received 4 treatments with SVN-2B plus IFNβ. The primary endpoint was progression-free survival (PFS) after initiation of Step 1 treatment. Secondary endpoints included immunological effects assessed by analysis of PBMCs after Step 1. Eighty-three patients were randomly assigned to receive SVN-2B plus IFNβ (n = 30), SVN-2B (n = 34), or placebo (n = 19). No significant improvement in PFS was observed. Survivin 2B-specific CTLs were found to be increased in the SVN-2B plus IFNβ group by tetramer assay. Among patients who participated in Step 2, those who had received SVN-2B plus IFNβ in Step 1 showed better overall survival compared with those who had received placebo in Step 1. Patients vaccinated with SVN-2B plus IFNβ did not have improved PFS, but showed significant immunological reaction after vaccination. Subgroup analysis suggested that a longer SVN-2B plus IFNβ vaccination protocol might confer survival benefit. (Clinical trial registration number: UMIN 000012146).
Diabetic Ketoacidosis in Cystic Fibrosis (1992)

The clinical presentation and the presence of immunologic and genetic markers characteristic of type I diabetes mellitus supports the concordance of cystic fibrosis and type I diabetes mellitus in this patient.
Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats (2010)

High-calorie food leads to nonalcoholic fatty liver disease (NAFLD) through dysregulation of genes involved in lipid metabolism, but the precise mechanism remains unclear. DNA methylation represents one of the mechanisms that contributes to dysregulation of gene expression via interaction with environmental factors. Berberine can alleviate fatty liver in db/db and ob/ob mice. Here, we investigated whether DNA methylation is involved in the pathogenesis of NAFLD induced by a high-fat diet (HFD) and whether berberine improves NAFLD through influencing the methylation status of promoters of key genes. HFD markedly decreased the mRNA levels encoding CPT-1alpha, MTTP, and LDLR in the liver. In parallel, DNA methylation levels in the MTTP promoter of rats with NAFLD were elevated in the liver. Interestingly, berberine reversed the downregulated expression of these genes and selectively inhibited HFD-induced increase in the methylation of MTTP. Consistently, berberine increased hepatic triglyceride (TG) export and ameliorated HFD-induced fatty liver. Furthermore, a close negative correlation was observed between the MTTP expression and its DNA methylation (at sites -113 and -20). These data indicate that DNA methylation of the MTTP promoter likely contributes to its downregulation during HFD-induced NAFLD and, further, that berberine can partially counteract the HFD-elicited dysregulation of MTTP by reversing the methylation state of its promoter, leading to reduced hepatic fat content.
Polyglycolic acid sheets for repair of refractory esophageal fistula (2015)

Gastrointestinal fistulas have been treated endoscopically with various devices, but endoscopic management is occasionally difficult [1]. Here we report a case of refractory esophageal fistula successfully closed using polyglycolic acid (PGA) sheets.
Spastic Paretic Stiff-Legged Gait (2001)

These findings, in conjunction with previous studies, support the likelihood of multiple mechanisms for reduced knee flexion in swing. Alternatively, some of the joint kinetic differences could be compensations for or associated with reduced knee flexion in swing. The substantial variability among subjects implies that despite a similar visual appearance of reduced knee flexion among subjects with a spastic paretic stiff-legged gait pattern, each individual has unique mechanisms associated with this observed gait pattern.
Understanding the Mechanisms of Proteinuria: Therapeutic Implications (2012)

A large body of evidence indicates that proteinuria is a strong predictor of morbidity, a cause of inflammation, oxidative stress and progression of chronic kidney disease, and development of cardiovascular disease. The processes that lead to proteinuria are complex and involve factors such as glomerular hemodynamic, tubular absorption, and diffusion gradients. Alterations in various different molecular pathways and interactions may lead to the identical clinical end points of proteinuria and chronic kidney disease. Glomerular diseases include a wide range of immune and nonimmune insults that may target and thus damage some components of the glomerular filtration barrier. In many of these conditions, the renal visceral epithelial cell (podocyte) responds to injury along defined pathways, which may explain the resultant clinical and histological changes. The recent discovery of the molecular components of the slit diaphragm, specialized structure of podocyte-podocyte interaction, has been a major breakthrough in understanding the crucial role of the epithelial layer of the glomerular barrier and the pathogenesis of proteinuria. This paper provides an overview and update on the structure and function of the glomerular filtration barrier and the pathogenesis of proteinuria, highlighting the role of the podocyte in this setting. In addition, current antiproteinuric therapeutic approaches are briefly commented.
Depolarization of Surface‐Enhanced Raman Scattering Photons from a Small Number of Molecules on Metal Surfaces (2013)

This chapter summarizes the depolarization of surface&hyphen;enhanced Raman scattering (SERS) photons by giving several examples from previous reports. The documented observation of SERS depolarization reveals optical properties of the metallic nanostructures, and the contribution of adsorbed molecules to the depolarization is also suggested. The chapter discusses a method for observing polarized SERS. It considers the application to electrified interfaces after examining SERS depolarization for various vibrational modes. Finally, it talks about potential applications of spectroelectrochemical methods for monitoring electrochemical processes at a single molecule level. The stability of the metal structure is checked by a polarized Rayleigh scattering light measurement.
Biothiols as Chelators for Preparation of N-(aminobutyl)-N-(ethylisoluminol)/Cu2+ Complexes Bifunctionalized Gold Nanoparticles and Sensitive Sensing of Pyrophosphate Ion (2014)

In this work, chemiluminescence (CL) reagent and catalyst metal ion complexes bifunctionalized gold nanoparticles (BF-AuNPs) with high CL efficiency were synthesized via an improved synthesis strategy. Biothiols, such as cysteine (Cys), cysteinyl-glycine (Cys-Gly), homocysteine (Hcy), and glutathione (GSH), instead of 2-[bis[2-[carboxymethyl-[2-oxo-2-(2-sulfanylethylamino)ethyl]amino]ethyl]amino]acetic acid (DTDTPA), were used as new chelators. N-(aminobutyl)-N-(ethylisoluminol) (ABEI) was used as a model of CL reagents and Cu(2+) as a model of metal ion. In this strategy, biothiols were first grafted on the surface of ABEI-AuNPs by Au-S bond. Then, Cu(2+) was captured onto the surface of ABEI-AuNPs by the coordination reaction to form BF-AuNPs. The CL intensity of Cu(2+)-Cys/ABEI-AuNPs was 1 order of magnitude higher than that of DTDTPA/Cu(2+)-ABEI-AuNPs synthesized by the previous work. Moreover, strong CL emission of Cu(2+)-Cys/ABEI-AuNPs was also observed in neutral pH conditions. In addition, the present BF-AuNPs synthesis method exhibited advantages over the previous method in CL efficiency, simplicity, and synthetic rate. Finally, by virtue of Cu(2+)-Cys/ABEI-AuNPs as a platform, a simple CL chemosensor for the sensitive and selective detection of pyrophosphate ion (PPi) was established based on the competitive coordination interactions of Cu(2+) between Cys and PPi. The method exhibited a wide detection range from 10 nM to 100 μM, with a low detection limit of 3.6 nM. The chemosensor was successfully applied to the detection of PPi in human plasma samples. It is of great application potential in clinical analysis. This work reveals that BF-AuNPs could be used as ideal nanointerface for the development of novel analytical methods.
pH Measurement Problems Affecting Assay of Carcinoembryonic Antigen (1975)

Measurments with combination pH electrodes of the pH of the dilute buffers used in a commercial kit (CEA-Roche) for assay of carcinoembryonic antigen resulted in pH values 0.1 to 0.3 unit lower than pH values measured on an electrode system with a capillary junction. If the pH values of these buffers were adjusted, based on such measurements, an error in the assay of 0.2 to 0.6 ng/ml in the 1.5-3.0 ng/ml range would result. We recommend that the pH of dialyzed samples and of the working ethylenediaminetetraacetate and ammonium acetate-acetic acid buffers be monitored with pH electrodes that have a capillary junction between sample and saturated KCI, as is true of most blood-pH instruments. We also recommend use of a 1 mol/liter rather than 2.5 mol/liter stock ammonium acetate-acetic acid buffer, because of the closer similarity of the pH of buffers at this molarity to those at 0.01 mol/liter.
The functionally antagonistic POU family transcription factors Brr-3a and Brn-3b show opposite changes in expression during the growth arrest and differentiation of human neuroblastoma cells (1996)

The Brn-3a and Brn-3b POU family transcription factors have previously been shown to have functionally antagonistic effects, with Brn-3a activating specific gene promoters which are repressed by Brn-3b. We show here that proliferating cell lines of human neuroblastoma origin have a high ratio of Brn-3b to Brn-3a compared with other cell lines derived from related tumours. Moreover, the level of Brn-3a rises and that of Brn-3b falls when neuroblastoma cell lines are exposed to treatments which induce a cessation of proliferation. Such treatments also result in the activation of a test promoter which is normally stimulated by Brn-3a and repressed by Brn-3b. Our findings suggest that these antagonistic factors may play a key role in regulation of gene expression during human neuroblastoma differentiation and could thus represent a potential therapeutic target for treatments designed to induce such differentiation.
Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells (2020)

Light-inducible dimerization protein modules enable precise temporal and spatial control of biological processes in non-invasive fashion. Among them, Magnets are small modules engineered from the <i>Neurospora crassa</i> photoreceptor Vivid by orthogonalizing the homodimerization interface into complementary heterodimers. Both Magnets components, which are well-tolerated as protein fusion partners, are photoreceptors requiring simultaneous photoactivation to interact, enabling high spatiotemporal confinement of dimerization with a single excitation wavelength. However, Magnets require concatemerization for efficient responses and cell preincubation at 28°C to be functional. Here we overcome these limitations by engineering an optimized Magnets pair requiring neither concatemerization nor low temperature preincubation. We validated these 'enhanced' Magnets (eMags) by using them to rapidly and reversibly recruit proteins to subcellular organelles, to induce organelle contacts, and to reconstitute OSBP-VAP ER-Golgi tethering implicated in phosphatidylinositol-4-phosphate transport and metabolism. eMags represent a very effective tool to optogenetically manipulate physiological processes over whole cells or in small subcellular volumes.
Variation in Delivery of Palliative Radiotherapy to Persons Dying of Cancer in Nova Scotia, 1994 to 1998 (2001)

Variations observed in delivery of palliative RT should prompt further investigation into equity of access to clinically appropriate, palliative radiation consultation and treatment.
Atlas‐based knee cartilage assessment (2011)

Magnetic resonance imaging analysis of knee cartilage properties at corresponding anatomic locations could be a valuable tool in studies of knee osteoarthritis by enabling accurate comparisons at practically any region. A technique of this kind is presented in this study. The proposed technique is based on gray-level bone matching using affine transformations and free-form deformations thus eliminating the need of bone segmentations and landmark matching. Sixteen subjects of the osteoarthritis initiative with knee osteoarthritis (10 from baseline; 6 from 24-month follow-up) were included in this study. Baseline subjects were used to create a gray-level atlas of the patella with its corresponding mean cartilage thickness and T2 maps. Follow-up subjects were used to validate atlas-based point-to-point cartilage comparisons. All registrations were qualitatively evaluated with fused gray-level images of registered patellas. Quantitative evaluation was performed based on mean values of minimum Euclidean distances between matched bone-cartilage interfaces. A mean distance of 0.554 mm was obtained between the subjects used to build the atlas, and a mean distance of 0.633 mm was found between the atlas and validation subjects. The technique can be applied to other anatomical regions and with other cartilage measures. Qualitative and quantitative results demonstrate the accuracy of the technique and warrant its application in larger cross-sectional and longitudinal studies of osteoarthritis.
Spin-Polarization Transfer in Colloidal Magnetic-Plasmonic Au/Iron Oxide Hetero-nanocrystals (2012)

We report on the unprecedented direct observation of spin-polarization transfer across colloidal magneto-plasmonic Au@Fe-oxide core@shell nanocrystal heterostructures. A magnetic moment is induced into the Au domain when the magnetic shell contains a reduced Fe-oxide phase in direct contact with the noble metal. An increased hole density in the Au states suggested occurrence of a charge-transfer process concomitant to the magnetization transfer. The angular to spin magnetic moment ratio, m(orb)/m(spin), for the Au 5d states, which was found to be equal to 0.38, appeared to be unusually large when compared to previous findings. A mechanism relying on direct hybridization between the Au and Fe states at the core/shell interface is proposed to account for the observed transfer of the magnetic moment.
Effect of Temperature on Drilling Mud Resistivities (1959)

Abstract A cell is described for measuring drilling mud resistivities at temperatures up to 350°F. Rm, Rmf and Rmc were measured at temperatures from 75 to 225°F with 100 psi pressure maintained on the mud system. Hence, Rmc is measured on the undisturbed mud cake under differential pressure. Fifteen synthetic mud samples and 25 field samples were measured. Some of the more important results areThe effect of elevated temperature on Rmf and Rmc is not the same as for NaCl solutions having corresponding resistivities at 75°F.The resistivity ratios, Rmf/Rm and Rmc/ Rm, vary with temperature in a different manner for different muds.Resistivity ratios may be widely different for different muds.Rmc may be different for undisturbed mud cake under differential pressure than when it is disturbed for measurement.Some chemical additives greatly affect the resistivity values as well as resistivity ratios.Mud resistivities may vary widely while drilling. Introduction Quantitative interpretation of electric logs requires reliable values for the mud resistivity, Rm, the mud filtrate resistivity, Rmf, and the mud cake resistivity, Rmc, under borehole conditions. For example, the resistivity of the formation water, Rw, is often calculated from the self-potential curve by the equation: In this equation, K has a value which is relatively constant for certain conditions of lithology and borehole temperature within a specified area. Thus, in the use of this equation to find Rw, it is evident that an error in the determination of Rmf will result in an error of like magnitude in the calculation of Rw. Rm is sometimes measured in the borehole with the collapsed microsonde but it is more difficult to make routine measurements of Rmf and Rmc under borehole conditions. When these resistivities are determined by sample measurements at the surface the correction to borehole conditions is of major importance. Temperature, pressure and differential pressure are some physical fact is that may affect resistivity values but temperature is by far the most important. Loan found no measureable effect of pressure on Rm up to 1,000 psi, but he found that Rmf and Rmc are affected by differential pressure. For differential pressures of 100 psi and 1,000 psi, Rmf was as much as 20 per cent greater for the higher pressure but Rmc was as much as 10 per cent smaller for the higher pressure.
IV. Congress of the Mexican Association of Ozonetherapy. (2013)

IV. Congress of the Mexican Association of Ozonetherapy. IV Congreso Mexicano de Ozonoterapia. AMOZON
Delay Guarantees for Throughput-Optimal Wireless Link Scheduling (2009)

We consider the question of obtaining tight delay guarantees for throughout-optimal link scheduling in arbitrary topology wireless ad-hoc networks. We consider two classes of scheduling policies: 1) a maximum queue-length weighted independent set scheduling policy, and 2) a randomized independent set scheduling policy where the independent set scheduling probabilities are selected optimally. Both policies stabilize all queues for any set of feasible packet arrival rates, and are therefore throughput-optimal. For these policies and i.i.d. packet arrivals, we show that the average packet delay is bounded by a constant that depends on the chromatic number of the interference graph, and the overall load on the network. We also prove that this upper bound is asymptotically tight in the sense that there exist classes of topologies where the expected delay attained by any scheduling policy is lower bounded by the same constant. Through simulations we examine the scaling of the average packet delay with respect to the overall load on the network, and the chromatic number of the link interference graph.
A general purpose unequal probability sampling plan (1982)

We present a general purpose unequal probability without replacement sampling plan with fixed sample size. In contrast to existing such plans, our scheme keeps the sample size fixed and lets the population units enter the sample one at a time through a carefully designed random mechanism. Consequently, all high-order inclusion probabilities can be easily computed.
SWRL-IQ: A Prolog-based Query Tool for OWL and SWRL. (2012)

Abstract. We present SWRL-IQ (SWRL Inference and Query Tool), a Protégé plug-in that allows users to create, edit, save, and submit queries to an underlying inference engine based on XSB Prolog. The tool distinguishes itself from other reasoning tools by a number of features, including goal-oriented backward-chaining reasoning, flexible constraint handling that allows for very declarative rules and queries, powerful SWRL extensions, and tracing and debugging features for explanation of reasoning results. Together, these features allow SWRL to be used as a powerful Logic Programming language that is tightly integrated with OWL ontologies. SWRL-IQ was motivated by the needs of a very complex problem domain: distributed military training and testing. The system is implemented in a flexible way to allow for different syntax front ends and reasoning back ends. 1