gebhart/patrepeval huggingface dataset:
Incidence and Contributing Factors for Palatal Fistula after Primary Palatoplasty in a Medical Collaboration Program in Madagascar (2018)

We have been conducting medical collaboration programs for cleft lip and palate in the Republic of Madagascar for seven years, from 2011 to 2017. The purpose of this study was to investigate the incidence of fistula after primary palatoplasty in the Republic of Madagascar, which is a developing country. A further objective was to determine if the group of patients in Madagascar had an increased incidence of palatal fistula compared to a similar group of patients in Japan, and to examine the factors that might be involved in any increase. We conducted a survey of the cleft type, age at time of surgery, and fistula incidence in 44 patients （28 males and 16 females） in Madagascar. The age at the time of surgery was 11 months to 29 years （average, 7 years and 8 months）, and the cleft types were 0 class Ⅰ, 14 class Ⅱ, 18 class Ⅲ, and 12 class Ⅳ, by the Veau classifi­cation. We used a modified two-flap palatoplasty for palatal closure. In addition to the selection of surgical technique, the factors which are suggested to influence the incidence of fistula include the experience of the surgeon, and the extent of the cleft. The incidence of postoperative fistula complication in these patients was zero. In medical collaboration settings in developing countries, there are factors which may delay wound healing, such as poor oral hygiene, poor nutrition, and instability of the flap blood flow. Understanding such factors in surgery is important to avoid palatal fistula. We report that a palatal fistula incidence rate of 0% can be achieved by avoiding those factors which contribute to fistula formation.
Characterizing Disproportionate Permeability Reduction Using Synchrotron X-Ray Computed Microtomography (2001)

Abstract X-ray computed microtomography was used to investigate why gels reduce permeability to water more than that to oil in strongly water-wet Berea sandstone and in an oil-wet porous polyethylene core. Although the two porous media had very different porosities (22% versus 40%), the distributions of pore sizes and aspect ratios were similar. A Cr(III)-acetate-HPAM gel caused comparable oil and water permeability reductions in both porous media. In both cores, the gel reduced permeability to water by a factor 80 to 90 times more than that to oil. However, the distributions of water and oil saturations (versus pore size) were substantially different before, during, and after gel placement. The disproportionate permeability reduction appeared to occur by different mechanisms in the two porous media. In Berea, gel caused disproportionate permeability reduction by trapping substantial volumes of oil that remained immobile during water flooding. With this high trapped oil saturation, water was forced to flow through narrow films, through the smallest pores, and through the gel itself. In contrast, during oil flooding, oil pathways remained relatively free from constriction by the gel. In the polyethylene core, oil trapping did not contribute significantly to the disproportionate permeability reduction. Instead, oil films and a relatively small number of pore pathways provided conduits for the oil. For reasons yet to be understood, the small pore pathways appeared largely unavailable for water flow.
Enzymatic Degradation of Colistin Isolation and Identification of α-N-Acyl α, γ-Diaminobutyric Acid and Colistin Nonapeptide (1973)

Colistin, a fatty acyl peptide antibiotic, was attacked by proteolytic enzymes such as papain, ficin and bromelain, and as degradation product, a peptide portion retaining the ring structure of colistin was liberated. In contrast, an analogous antibiotic polymyxin B showed a characteristic resistance to the catalytic activity of papain. Colistin nonapeptide and α-N-fatty acyl α, γ-diaminobutyric acid were obtained as products from the above enzymatic hydrolyzates of colistin and their chemical and physicochemical properties were investigated. Contrary to colistin, this colistin nonapeptide was inactive to Escherichia coli. NIHJ and to many other strains even at a concentration of 800mcg/ml by the agar dilution method. As α-N-fatty acyl α, γ-diaminobutyric acid which is rest part of colistin was added to colistin nonapeptide, antimicrobial activity of colistin nonapeptide did not increase.
Mouse embryonic stem cells resist c-Jun induced differentiation when in suspension (2018)

The oncogene <i>c-Jun</i> plays a key role in development and cancer. Yet, its role in cell fate decision remains poorly understood at the molecular level. Here we report that c-Jun confers different fate decisions upon mouse embryonic stem cells (mESCs) in adhesion vs suspension culture. We developed a Tet-on system for temporal induction of c-Jun expression by Doxycycline treatment in mESCs. We show that mESCs carrying the inducible c-Jun TetOn remain pluripotent and grow slowly in suspension when c-Jun expression is induced, whilst when the cells adhere they undergo differentiation and show normal proliferative potential upon c-Jun induction. Our data indicates that c-Jun pushes mESCs in suspension into cell cycle arrest at G1/S, by activating the cell cycle inhibitors Cdkn1a/b and Cdkn2/a/b/c. Despite this cell cycle arrest, they can still re-enter the cell cycle upon transfer to an adhesive surface, and grow into typical mESC colonies, albeit at a lower efficiency. These results demonstrate that mESCs respond to induced c-Jun overexpression differently in suspension or adherent cultures. Our results suggest that cells in suspension may be more resistant to differentiation than when they adhere.
Ranking specialization for web search (2010)

Many ranking algorithms applying machine learning techniques have been proposed in informational retrieval and Web search. However, most of existing approaches do not explicitly take into account the fact that queries vary significantly in terms of ranking and entail different treatments regarding the ranking models. In this paper, we apply a divide-and-conquer framework for ranking specialization, i.e. learning multiple ranking models by addressing query difference. We first generate query representation by aggregating ranking features through pseudo feedbacks, and employ unsupervised clustering methods to identify a set of ranking-sensitive query topics based on training queries. To learn multiple ranking models for respective ranking-sensitive query topics, we define a global loss function by combining the ranking risks of all query topics, and we propose a unified SVM-based learning process to minimize the global loss. Moreover, we employ an ensemble approach to generate the ranking result for each test query by applying a set of ranking models of the most appropriate query topics. We conduct experiments using a benchmark dataset for learning ranking functions as well as a dataset from a commercial search engine. Experimental results show that our proposed approach can significantly improve the ranking performance over existing single-model approaches as well as straightforward local ranking approaches, and the automatically identified ranking-sensitive topics are more useful for enhancing ranking performance than pre-defined query categorization.
Différenciation de souches du virus de la rhinotrachéite infectieuse bovine (Bovine herpesvirus 1) par l'analyse du DNA viral après digestion par l'endonucléase de restriction Eco R1 (1983)

peer reviewed
Images of photoelectrons formed in intense laser fields (1993)

Spatial distributions of photoelectrons produced by multiphoton ionization of xenon atoms are recorded by projecting the expanding photoelectron cloud onto a two-dimensional position sensitive detector. The projected image provides a direct view of the squared angular wave functions of the free electrons as well as their energy distribution. The results confirm recent observations that intermediate state resonances with 5f and 4f character establish the dominant ionization paths at low intensity, for short pulse excitation at 640 and 620 nm. At higher intensity more complex superpositions occur with formation of electrons with continuous distributions at low energies.
Anomalous Threshold Laws in Quantum Sticking (2003)

It has been stated that for a short-ranged surface interaction, the probability of a low-energy particle sticking to a surface always vanishes as s approximately k with k-->0 where k=sqrt[E]. Deviations from this so-called universal threshold law are derived using a linear model of particle-surface scattering. The Fredholm theory of integral equations is used to find the global conditions necessary for a convergent solution. The exceptional case of a zero-energy resonance is considered in detail. Anomalous threshold laws, where s approximately k(1+alpha),alpha>0 as k-->0, are shown to arise from a soft gap in the weighted density of states of excitations; alpha is determined by the behavior of the weighted density of states near the binding energy.
MASS-PROPAGATION AND BIOREACTOR-BASED TECHNOLOGIES FOR GERMPLASM CONSERVATION, EVALUATION AND INTERNATIONAL DISTRIBUTION OF BREADFRUIT (2007)

ISHS I International Symposium on Breadfruit Research and Development MASS-PROPAGATION AND BIOREACTOR-BASED TECHNOLOGIES FOR GERMPLASM CONSERVATION, EVALUATION AND INTERNATIONAL DISTRIBUTION OF BREADFRUIT
Kv7 Positive Modulators Reduce Detrusor Overactivity and Increase Bladder Capacity in Rats (2011)

The effects of the Kv 7 channel modulators retigabine (opener) and XE991 (blocker) on rat bladder function were investigated ex vivo and in vivo to assess the potential of Kv 7 openers for the treatment of overactive bladder. In organ bath studies, capsaicin-stimulated rat urinary bladder rings were exposed to retigabine and XE991 and the effect on tension and amplitude was evaluated. In anaesthetized rats, retigabine (0.01-1 mg/kg, i.v.) effects on bladder function, in which overactivity was induced by continuous infusion of 0.5% acetic acid, were assessed. The effect of retigabine (10 mg/kg, p.o.) on cystometric parameters was also measured in conscious rats with capsaicin-induced irritated bladders. Localization of Kv 7 subunits within bladder tissue was analysed by RT-qPCR and western blotting. In organ bath studies, retigabine robustly reduced capsaicin-induced contractility of bladder rings and this effect was blocked by XE991 confirming the specificity of action via Kv 7 channels. In anaesthetized rats with acetic acid-irritated bladders, retigabine markedly increased bladder capacity with no concomitant reduction in blood pressure. Retigabine also reduced bladder pressure and delayed voiding in conscious rats with capsaicin-irritated bladders. Kv 7.1, Kv 7.4 and Kv 7.5 subunit mRNA transcripts were detected in rat bladder. Western blot analysis confirmed that Kv 7.4 subunit protein was expressed in rat bladder. These results suggest that retigabine and other Kv 7 channel positive modulators may have beneficial effects on bladder overactivity partly via activation of Kv 7 channels expressed in bladder tissue.
Risk factors for renal dysfunction after coronary surgery: the role of cardiopulmonary bypass technique (1994)

We studied 316 patients undergoing cardiopulmonary bypass for coronary artery surgery in order to determine perioperative risk factors for postoperative renal dysfunction. A preliminary univariate analysis was performed by chi 2 analysis for categorical data and Mann-Whitney U-test for continuous variables to detect significant correlations between each risk factor and the occurrence of moderate or severe renal dysfunction. Subsequently, a multiple logistic regression was applied to the three risk factors identified as predictive for severe renal dysfunction. Low cardiac output syndrome and need for banked blood transfusions combined with a low haematocrit value during cardiopulmonary bypass increase the probability of severe renal dysfunction in the postoperative course.
Data on the uptake of CpG-loaded amino-dextran nanoparticles by antigen-presenting cells (2021)

Cytosine-phosphate-guanine (CpG) oligonucleotides are commonly-used vaccine adjuvants to promote the activation of antigen-presenting cells (APCs). To mount an effective immune response, CpG needs to be internalized and bind to its endosomal Toll-like receptor 9 (TLR-9) inside the APCs. Using flow cytometry and fluorescence microscopy, this article presents the cellular uptake data of the amino-dextran nanoparticle (aDNP) and aDNP loaded with CpG immobilized on its surface by either electrostatic adsorption or covalent conjugation. The uptake of fluorescently-labelled aDNPs by murine splenic dendritic cells and macrophages was determined by flow cytometry and uptake by murine bone-marrow-derived dendritic cells was evaluated by fluorescence microscopy. The data presented in this paper correlates with the <i>in vitro</i> immune-stimulatory activity observed for the two different CpG loading methods in the research article "<i>Nanoparticle system based on amino-dextran as a drug delivery vehicle: immune-stimulatory CpG-oligonucleotide loading and delivery</i>" (Nguyen <i>et al</i>., 2020) [1]. The data provide experimental evidence for a better understanding how the nanoparticle surface loading method of CpG influences the uptake of these nanoparticles by antigen-presenting cells as a step guide in the design of more effective vaccine formulations.
S-shaped negative differential resistance modeling in electro-thermal simulation of phase-change memory programming (2007)

Electro-thermal modeling has been commonly employed to model the RESET (crystalline-to-amorphous) transition in phase-change memory devices. However, to fully model the SET (amorphous-to-crystalline) transition, it is required to comprehend the S-shaped negative differential resistance (NDR) that precedes the phase transition, as input current is ramped up. Carrier dynamics on nanosecond time scales have been invoked to model the "snapback" phenomenon. To build S-shaped NDR models within commercial electrothermal simulation packages, we consider various resistivity models which may be calibrated to provide a good flt with experimental data. We find that regardless of the model, it is necessary to include a constant offset in the resistivity formula, in order to consistently obtain the observed ON state portion of the l-V curve.
<title>Multicolor instrumentation for direct fluorescent detection of nucleic acids in a microchip format</title> (1998)

Deposition of nucleic acids on solid support in the form of high density arrays (a DNA microarray) creates a powerful nonelectrophoretic technology for highly parallel genetic analysis. Microarrays have applications in the areas of DNA sequencing, genetic mutation detection and gene expression monitoring. We report here the design and utility of an experimental instrument for microchip parallel hyperspectral fluorescent imaging. The instrument integrates in-line laser excitation of microarray, parallel fluorescent spectrometry with cooled CCD and dye-base spectral classification software. Instrument has been applied for imaging detection, spectral analysis and base classification of Genetic Bit Analysis (GBA) reactions in a microchip format on a glass support. GBA is a solid phase DNA sequence analysis method that provides single nucleotide resolution by specific extension of dye-labeled dideoxynucleotidetriphosphates (ddNTPs). GBA testing yields one or two different ddNTPs on any given microarray spot, so analysis must resolve any pair wise combination of all possible ddNTPs labeled with distinct fluorescent dyes.
Discovery of “folded DNA” structures in human cells: Potential drug targets (2018)

The newly identified "folded DNA" structures ("I-motifs" and "G-quadruplexes") could represent novel drug-discovery targets, most likely for cancer.
Antiviral activity of medicinal plant extracts (1997)

Dichloromethane and ethanol extracts of 12 plants with a history of use in traditional medicine, were tested for antiviral activity against herpes simplex type I. The most potent inhibition was shown by ethanol extracts of Eugenia jambos, Cistus populifolius, Lippia alba, Chiranthodendron pentadactylon and Tuberaria lignosa. These extracts, and others that had no effect, were chosen for more extensive studies against poliovirus type 1 and vesicular stomatitis virus. It was found that the ethanol extracts of Eugenia jambos, Chiranthodendron pentadactylon and Santolina oblongifolia inhibited the replication of VSV, but none of the extracts investigated had any effect on poliovirus replication. © 1997 John Wiley & Sons, Ltd.
An Implicit, Conservative Multi-Temperature MHD Algorithm (2000)

Abstract : A novel algorithm to accurately simulate realistic plasmas with constituent species at multiple temperatures using an extended MHD model was developed. The algorithm was based on a ROE-type approximate Riemann solver. The algorithm was implemented in a code to model the time-dependent, three-dimensional, arbitrary-geometry MHD model which includes viscous and resistive effects. The code was extended to include thermal diffusion for the constituent temperatures (neutrals, ions, and electrons). A time-dependent ionization model was added which self-consistently calculates the ionization fraction of the fluid. Energy loss mechanisms were added for the constituent fluid components. The algorithm was implemented on parallel supercomputers to allow the detailed modeling of realistic plasmas in complex three-dimensional geometries.
Improved conversion efficiency of as-grown InGaN/GaN quantum-well solar cells for hybrid integration (2014)

International audience
Electron diffraction studies of surface freezing in hexatic B films (1994)

Abstract Electron diffraction has been used to study the freezing in free-standing hexatic B films of several members of the n-alkyl 4′-n-alkyloxybiphenyl-4-carboxylate (nmOBC) homologous series. It was found that 65OBC exhibits the surface crystal E phase and the accompanying orientational epitaxy previously observed in 75OBC. In 46OBC, the surfaces also appear to attain a higher order ahead of the interior, but retain a six-fold symmetry before the entire film abruptly transforms to the crystal E phase. In 3(10)OBC, the behaviour is similar to that of 46OBC, but the film breaks prior to the observation of any crystal E transition.
Damage Detection of Frame Structure Using Harmonic Excitation Based on Uncertain Modeling and Measurements (2006)

A technique of structural damage detection was proposed which considers the effects of both measurement noise and modeling errors in the baseline finite element model. Damage that accompanies changes in structural parameters can be estimated for a damaged structure from the change between measured vibration responses and ones calculated from the analytical model of the intact structure. In practice, modeling errors exist in the analytical model due to material and geometric uncertainties and a reduction in the degrees of freedom as well as measurement errors, making identification difficult. To surmount these problems, bootstrap hypothesis testing, which enables statistical judgment without information about these errors, was introduced. The technique was validated by real vibration data for a three-story steel frame structure.
Passive acoustic metasurfaces for high-efficiency wavefront transformations (2017)

Metasurfaces have offered new degrees of freedom to control the propagation properties of acoustic waves. Gradient metasurfaces, first proposed in optics, and recently extended to acoustics, add an extra transverse momentum to the incident plane wave so that reflected and refracted waves can be rerouted without having to rely on conventional Snell’s Law. However, recent studies have shown that gradient metasurfaces cannot transfer all incident energy into the desired direction without causing unwanted parasitic diffraction and limiting the overall transformation efficiency. More sophisticated metasurface designs have considered impedance matching to address this issue, but this inherently requires the use of active and lossy materials for extreme wave transformations. In this talk, we present our recent efforts in designing passive acoustic metasurfaces with unitary efficiency in beam steering, even when considering extreme steering angles. We consider nonlocal surface impedance profiles and the use of bianisotropic inclusions, which are both effective routes to realize efficient metasurfaces without relying on gain elements. Our work opens new design approaches for metasurfaces, and it can improve the operational efficiency of metasurfaces.
Genetic programming approach to evaluate complexity of texture images (2016)

We adopt genetic programming (GP) to define a measure that can predict complexity perception of texture images. We perform psychophysical experiments on three different datasets to collect data on the perceived complexity. The subjective data are used for training, validation, and test of the proposed measure. These data are also used to evaluate several possible candidate measures of texture complexity related to both low level and high level image features. We select four of them (namely roughness, number of regions, chroma variance, and memorability) to be combined in a GP framework. This approach allows a nonlinear combination of the measures and could give hints on how the related image features interact in complexity perception. The proposed complexity measure MGP exhibits Pearson correlation coefficients of 0.890 on the training set, 0.728 on the validation set, and 0.724 on the test set. MGP outperforms each of all the single measures considered. From the statistical analysis of different GP candidate solutions, we found that the roughness measure evaluated on the gray level image is the most dominant one, followed by the memorability, the number of regions, and finally the chroma variance.
Variable Adhesion Abilities and Overlapping Antigenic Properties in PlacentalPlasmodium falciparumIsolates (2004)

The level of adhesion of placental parasites to chondroitin sulfate receptors is an important risk factor for LBW. Parasite heterogeneity suggests that they are composed of mixed adhesion phenotypes capable of inducing immune responses to a range of different and overlapping targets.
Tunneling magnetoresistance and quantum oscillations in bilayeredCa3Ru2O7 (2003)

We report the interplane resistivity, ${\ensuremath{\rho}}_{c},$ at high magnetic fields B, with different orientations together with structural and magnetic properties of bilayered ${\mathrm{Ca}}_{3}{\mathrm{Ru}}_{2}{\mathrm{O}}_{7},$ a Mott-like system with a gap of 0.1 eV. A wide array of conventionally unanticipated phenomena revealed in this work includes (1) a collapse of the c-axis lattice parameter at a metal-nonmetal transition, (2) quantum oscillations in ${\ensuremath{\rho}}_{c}$ in the gapped, nonmetallic state for the $B\ensuremath{\parallel}c$ axis, (3) interplane tunneling magnetoresistivity for the $B\ensuremath{\parallel}a$ or b axis, and yet conspicuously different anisotropies of the colossal magnetoresistivity and magnetization, and (4) a non-Fermi-liquid behavior in a metallic state fully recovered in high magnetic fields. The implications of the coexistence of these conflicting phenomena are discussed.
Irregular repeat accumulate codes (2000)

In this paper we will introduce an ensemble of codes called irregular repeat-accumulate (IRA) codes. IRA codes are a generalization of the repeat-accumulate codes introduced in [1], and as such have a natural linear time encoding algorithm. We shall prove that on the binary erasure channel, IRA codes can be decoded reliably in linear time, using iterater] sum-product decoding,a# ra#SJ a#SJ8T a#SJ8 close tocha#T36 ca pa#J464 Asimila# resulta#u ea#S to be true on the AWGN channel, although we have no proof of this. We illustrate our results with numerical and experimenta# examples.