gebhart/patrepeval huggingface dataset:
Prospective, Multi-Center, Pivotal Trial Evaluating the Safety and Effectiveness of Micro-Focused Ultrasound with Visualization (MFU-V) for Improvement in Lines and Wrinkles of the Décolletage (2014)

OBJECTIVE: Photodamage of the surrounding skin of the neck and chest area (décolletage) is often highlighted as patients continue to invest in rejuvenating their facial skin. This prospective, multi-center, single treatment study evaluated aesthetic improvement in lines and wrinkles of the décolleté with MFU-V. METHODS: 125 female subjects meeting inclusion and exclusion criteria were enrolled and completed one treatment on the chest using three transducers: 4 – 4.5mm (1.2J), 7 - 3.0mm (0.45J), and 10-1.5mm (0.20J). Pain was assessed using a validated scale (0-10) during the treatment. Standardized photographs were taken prior to treatment, immediately after treatment, and at each follow-up visit (day 90 and 180). Efficacy will be determined by blinded masked assessments at 180 days post treatment compared to baseline. Physician Global Aesthetic Improvement Scale (PGAIS) scores and Patient Satisfaction Questionnaire (PSQ) responses will be tabulated at days 90 and 180 post-treatment. RESULTS: Treated subjects (n=125) presented with a mean age of 56.7 years old (37.5 – 70.4), mean BMI of 24.7 (18.3 – 38.3) and Fitzpatrick skin types I-IV (I-0.8%, II – 48.0%, III – 41.6% and IV -9.6%). The mean pain score at each depth was 6.2 at 4.5mm, 5.9 at 3.0mm, and 4.8 at 1.5mm. Masked Assessment results show improvement in 66.4% of subjects at 180 days using the Last Value Carried Forward method. CGAIS scores show 75.0% of subjects improved at 90 days and 66.4% at 180 days. At the 90-day visit, 83.6% of subjects noted an improvement and 65.5% were satisfied. Day 180 results show a similar trend with 82.7% of subjects noting improvement and 62.7% satisfied. Agreement was noted across all measures at both Day 90 and 180 time points, suggesting that improvements observed following treatment are clinically significant. Most notable is alignment in subject reported improvement and masked clinician assessment of improvement. Device safety was demonstrated, no serious adverse events reported. Of the adverse events, all were mild except two (1.9%) that were moderate, one of which was not device related. All events resolved. A typical result can be seen below (Figures 1 and 2).Figure 1: Pre-treatment, Before MFU-V Treatment.Figure 2: 180 Days Post 1 MFU-V Treatment.CONCLUSION: These results demonstrate significant reduction of wrinkles and lines, as well as tightening and toning of the Décolleté at three and six months after a single treatment using MFU-V. Comfort was managed with oral pre-treatment medications.
Abstract P96 (2015)

AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK
Essentials of mathematics (1973)

Part 1 Arithmetic: whole numbers fractions decimal fractions percentage square roots of numbers metric system of measurement number bases. Part 2 Algebra: operations with signed numbers operations with algebraic expressions multiplication and division the equation solving stated word problems special products and factoring fractions fractional equations systems of equations graphing exponents powers and roots radicals quadratic equations imaginary and complex numbers roots of equations systems involving quadratics inequalities ratio proportion variation. Part 3 Geometry: plane figures measurement of plane figures right angle circles geometric solids: prisms, cylinders, pyramids and cones spheres. Part 4 Logarithms: computation applications. Part 5 Trigonometry: trigonometric ratios tables of trigonometric ratios the right angle function of angles of any size trigonometric identities radian measure special angles composite ang
A comparative effectiveness of activated platelet-rich plasma versus autologous whole blood in the management of lateral epicondylitis: A randomized clinical trial of functional outcome (2018)

Background: Lateral epicondylitis (tennis elbow), a familiar term used to describe myriad of symptoms around the lateral aspect of elbow mainly due to intra-tendinous degeneration assosciated with ageing, repetitive movement and vascular compromise. Activated platelet-rich plama (PRP) and Autologous whole blood (AWB) injections represent new therapeutic options for chronic tendinopathies including tennis elbow. But from the literature, no firm conclusions can be drawn about the effectiveness of PRP versus AWB or the superiority of one method over the other. Our aim of study was to compare the effectiveness and functional outcome of both modalities. Methods: 50 patients with chronic lateral epicondylitis (>3 months) with restricted ROM were included in this study and randomized into 2 groups. Group 1 was treated with a single injection of 2 mL of autologous PRP (4.8 times of plasma) with 1ml of calcium chloride as activator and group 2 with 2 mL of AWB injection followed by elbow-strap, stretching and strengthening exercises for both groups. Pain and functional outcomes were assessed using visual analogue scale (VAS) and NIRSCHL staging (NS) at 0, 4, 8 weeks, 6 months and 12 months. Results: Pain variables including VAS and Nirschl scores improved significantly in both groups at short and intermediate duration but on long term follow up intervals PRP showed better improvement between groups regarding pain severity, functional improvement and recurrence rates. Conclusion: Both PRP and AWB injections are effective to treat chronic lateral epicondylitis but for longer duration the efficacy persisted with PRP seems to be superior than AWB.
MYOBLAST CELL GRAFTING INTO HEART MUSCLE: Cellular Biology and Potential Applications (1999)

This review surveys a wide range of cellular and molecular approaches to strengthening the injured or weakened heart, focusing on strategies to replace dysfunctional, necrotic, or apoptotic cardiomyocytes with new cells of mesodermal origin. A variety of cell types, including myogenic cell lines, adult skeletal myoblasts, immoratalized atrial cells, embryonic and adult cardiomyocytes, embryonic stem cells, tetratoma cells, genetically altered fibroblasts, smooth muscle cells, and bone marrow-derived cells have all been proposed as useful cells in cardiac repair and may have the capacity to perform cardiac work. We focus on the implantation of mesodermally derived cells, the best developed of the options. We review the developmental and cell biology that have stimulated these studies, examine the limitations of current knowledge, and identify challenges for the future, which we believe are considerable.
Acoustic Correlates of Emphasis in Jordanian Arabic: Preliminary Results (2003)

Most, if not all, dialects of the Arabic language are characterized by features of pharyngealization – traditionally called emphasis. This phenomenon has triggered a great amount of research as early as the eighth century AD. Classical Arab linguists have described emphasis in terms of production with
T cell responses are governed by avidity and costimulatory thresholds (1996)

We analyzed the avidity and CD28-mediated co-stimulatory requirements for the activation of T cells in vivo and in vitro. The strength of the T cell/antigen-presenting cell interaction was varied by using altered peptide ligands for stimulation. Co-stimulatory requirements were studied using T cells from CD28-deficient mice. The results indicate that T cell activation is not an all-or-nothing event, but occurs in distinct steps. For each step, a certain avidity, co-stimulatory threshold or both, must be met. Depending upon the strength of the interaction between the T cell receptor and the major histocompatibility complex/peptide and the presence of CD28 co-stimulatory signals, T cells may undergo blast formation alone or proliferate or eventually both proliferate and differentiate to effector cells. Thus, T cell activation is governed by both avidity and co-stimulatory thresholds.
Abstract 4910: Integrated Approach By Using Coronary Flow Velocity Reserve And Coronary Flow Velocity Patterns In Predicting Long-term Adverse Cardiac Events In Acute Myocardial Infarction (2008)

Background: The microvascular function was known to be an useful predictor of left ventricular functional changes and clinical outcomes in ST-segment elevation myocardial infarction (STEMI). We evaluated the usefulness of integrated approach by using coronary flow velocity reserve (CFR) and diastolic deceleration time (DDT) in the prediction of long-term major adverse cardiac events in STEMI. Methods and Results: Using an intracoronary Doppler wire, CFR, DDT and hyperemic microvascular resistance index (MVRI) were evaluated in 202 patients with first STEMI received reperfusion therapy within 24 hours after onset of symptoms. Major adverse cardiac events were the composite of cardiac death, recurrent myocardial infarction, congestive heart failure and stroke during an average follow-up period of 60 ± 39 months. Follow-up echocardiography was performed at 12 ± 9 months. CFR, DDT and MVRI had significant correlations with left ventricular regional wall motion score index at follow-up echocardiography (r =−0.441, p&lt;0.001; r = 0.413, p&lt;0.001; r =−0.485, p&lt;0.001, respectively). Using receiver-operating characteristics analysis, CFR ≤1.3 (sensitivity: 51%, specificity: 78%), DDT ≤577 ms (sensitivity: 72%, specificity: 62%) and MVRI &gt;2.7 (sensitivity: 68%, specificity: 67%) were the best cutoff values in the prediction of occurring the adverse cardiac events. In patients with CFR ≤1.3, DDT ≤577 ms, cardiac events were occurred in 18 patients (40.0 %) of 45 patients, whereas cardiac events were occurred in 12 patients (20.3%) of 59 patients with CFR &gt;1.3 and DDT ≤577 ms or CFR ≤1.3 and DDT &gt;577 ms (p= 0.048), 9 patients (9.1%) of 99 patients with CFR&gt;1.3 and DDT &gt;577 ms (p&lt;0.001). Ejection fraction at admission (p=0.009), MVRI (p =0.002) and DDT (p=0.023) were independent predictors in the prediction of long-term adverse cardiac outcomes during follow-up. Conclusions: Integrated approach by using CFR and DDT was useful in the prediction of long-term adverse cardiac events. MVRI and DDT were strong independent predictors of long-term adverse cardiac events in STEMI patients.
Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation (2001)

Numerous transcription factors allow haematopoietic cells to respond to lineage- and stage-specific cytokines and to act as their effectors. It is increasingly evident that the interferon regulatory factor-1 (IRF-1) transcription factor can selectively regulate different sets of genes depending on the cell type and/or the nature of cellular stimuli, evoking distinct responses in each. In the present study, we investigated mechanisms underlying the differentiation-inducing properties of granulocytic colony-stimulating factor (G-CSF) and whether IRF transcription factors are functionally relevant in myeloid differentiation. Both normal human progenitors and murine 32Dcl3 myeloblasts induced to differentiate along the granulocytic pathway showed an up-regulation of IRF-1 expression. Ectopic expression of IRF-1 did not abrogate the growth factor requirement of 32Dcl3 cells, although a small percentage of cells that survived cytokine deprivation differentiated fully to neutrophils. Moreover, in the presence of G-CSF, granulocytic differentiation of IRF-1-expressing cells was accelerated, as assessed by morphology and expression of specific differentiation markers. Down-modulation of c-Myb protein and direct stimulation of lysozyme promoter activity by IRF-1 were also observed. Conversely, constitutive expression of IRF-2, a repressor of IRF-1 transcriptional activity, completely abrogated the G-CSF-induced neutrophilic maturation. We conclude that IRF-1 exerts a pivotal role in granulocytic differentiation and that its induction by G-CSF represents a limiting step in the early events of differentiation.
Antiphospholipid Syndrome Nephropathy in Systemic Lupus Erythematosus (2002)

In the course of the antiphospholipid syndrome (APS), the existence of vaso-occlusive lesions capable of affecting numerous organs is now well established. The renal involvement attributable to primary APS, APS nephropathy (APSN), corresponds to vaso-occlusive lesions of the intrarenal vessels, associating side-by-side, acute thromboses with chronic arterial and arteriolar lesions, leading to zones of cortical ischemic atrophy. A retrospective study of 114 lupus patients undergoing renal biopsy was undertaken to determine the following: (1) if APSN can be found in the course of systemic lupus erythematosus (SLE); (2) if certain clinical and biologic factors can permit the prediction of the presence of APSN; and (3) if APSN is a superadded renal morbidity factor in lupus patients. This study shows the following: (1) APSN occurs in SLE (32% of patients with renal biopsies) in addition to, and independently of, lupus nephritis; (2) APSN is statistically associated with lupus anticoagulant but not with anticardiolipin antibodies; (3) APSN is associated with extrarenal APS, mainly arterial thromboses and obstetrical fetal loss, but not with the venous thromboses of APS; (4) APSN is an independent risk factor, over and above lupus nephritis, that contributes to an elevated prevalence of hypertension, elevated serum creatinine, and increased interstitial fibrosis. Thus, it seems likely that, because of its associations with hypertension, elevated serum creatinine, and increased interstitial fibrosis, APSN may worsen the prognosis in these patients. APSN may also have therapeutic significance in that its recognition should permit a better balance between immunosuppressor and antithrombotic and/or vasoprotective therapy. Finally, this study suggests that APSN should be considered as an element to be included in the classification criteria of APS.
Taking Account of Peak Areas when Interpreting Mixed DNA Profiles (1998)

This paper establishes a logical framework for taking account of peak areas when interpreting mixed DNA STR profiles. The principles apply wherever such data are available but they are illustrated here by means of data which have been collected from made up mixtures of known concentrations analyzed at short tandem repeat loci. The data have led to some modeling assumptions which are used for numerical examples. In actual casework the proportions of the various components will not be known and there is a discussion of whether they should be allowed for by integrating over a prior distribution. This is a conceptual paper, rather than a prescription for casework, and the scope for further work is outlined.
Evaluation of Stress/Strain Distribution near Notch in 3%Si Iron by EBSD Method (2015)

Diffraction method is very useful to evaluate the stress/strain of crystalline material. Especially, the X-ray method has been widely used for measurement of the stress in engineering components. However, when the very small measurement area is required, accuracy of determination by the X-ray method may be insufficient. On the other hand, spatial resolution of EBSD method becomes a nanometer order. In the present study, in-situ measurement of the stress/strain distribution near notch in 3%Si iron was carried out by EBSD method. Obtained results were compared with the results analyzed by the finite element method. The strain near notch could be measured within the scatter of ±500 micro strain. Ten point average value of the strain was almost identical to the macro strain distribution calculated by FEM. For the stress distribution in the elastic region, hundred point average value was coincident with the calculated result. For the plastic deformation, change of the angle of crystal rotation corresponds to the displacement of the specimen surface. Kernel averages misorientation increased with the plastic deformation.
Results of a pilot study of the effects of celecoxib on cancer cachexia in patients with cancer of the head, neck, and gastrointestinal tract (2007)

Cachectic patients receiving celecoxib gained weight, experienced increased BMI, and demonstrated improved QOL scores. Compliance was good and no adverse events were seen.
Seasonal Abundance of Lysogenic Bacteria in a Subtropical Estuary (1998)

Seasonal changes in the abundance of inducible lysogenic bacteria in a eutrophic estuarine environment were investigated over a 13-month period. Biweekly water samples were collected from Tampa Bay, Fla., and examined for prophage induction by mitomycin C treatment. At the conclusion of the study, we determined that 52.2% of the samples displayed prophage induction, as indicated by significant increases in viral direct counts compared with uninduced controls. Samples that displayed prophage induction occurred during the warmer months (February through October), when surface water temperatures were above 19 degreesC, and no induction was observed in November, December, or January. This study presents clear evidence that there is seasonal variation in the number of inducible lysogenic bacteria in an estuarine environment.
STUDIES IN THE POLYOXYPHENOL SERIES: III. SYNTHESES OF SUBSTITUTED PHENYLUREAS FROM METHYLATED AND ETHYLATED VANILLIN (1948)

The object of the work was to prepare alkoxylated derivatives of sym-diethyldiphenylurea from methylated and ethylated vanillin. Standard procedures for converting methylated vanillin to 3,4-dimethoxyaniline were extended to the syntheses of the known 3-methoxy-4-ethoxyaniline. The following derivatives of 3,4-dimethoxyaniline are believed to be new: the formanilide, m.p. 91 °C.; sulphonamide, m.p. 132 °C.; N-ethylsulphonamide, m.p. 94 °C.; N-ethylacetanilide, m.p. 62 °C.; and the N-ethylaniline, an uncrystallized oil. Condensations of the last with phosgene yielded the N-ethylcarbamyl chloride, m.p. 86 °C.; N-ethyl-NN'-NN′-(3,4-dimethoxyphenyl)-urea, m.p. 159 °C.; and the corresponding sym-N,N′-diethyl derivative, m.p. 79 °C. N,N′-di-(3,4-dimethoxyphenyl)-urea, m.p. 214 °C., was synthesized by a method that removed previous doubt about its structure. The derivatives of 3-methoxy-4-ethoxyaniline believed to be new are: the hydrochloride, m.p. 221 °C.; the formanilide, m.p. 103 °C.; the N-ethylformanilide, m.p. 80 °C.; and the N-ethylaniline, m.p. 43 °C. Condensations of the last with phosgene gave the N-ethylcarbamyl chloride, m.p. 85 °C.; N-ethyl-N,N′-di-(3-methoxy-4-ethoxyphenyl)-urea, m.p. 127 °C. and the corresponding N,N′-diethyl derivative, m.p. 51 °C. A condensation of 3-methoxy-4-ethoxyaniline with urea resulted in the corresponding monosubstituted urea, m.p. 177 °C.; and N,N′-disubstituted urea, m.p. 209 °C. Yields were uniformly higher than those obtained in the 3,4-dimethoxy series.
Statistical superposition of crosstalk effects in cable bundles (2013)

This paper deals with the analytical derivation of phasor-domain statistical properties of crosstalk in random wire cables due to the superposition of several sources of electromagnetic interference. In this study, statistical characterization of crosstalk in cable bundles, which is available in literature for the case of one source of interference, is extended to the case of several sources operating simultaneously. The superposition of crosstalk effects is analysed in statistical terms, also taking into account the correlation between crosstalk contributions. A further random contribution, which is included in the proposed statistical model, is given by the phase relationship between the sources of interference. Analytical approximate expressions for the crosstalk mean value, variance, and probability density function are derived as functions of the cable bundle features and sources.
Building a digital twin for intelligent optical networks [Invited Tutorial] (2023)

To support the development of intelligent optical networks, accurate modeling of the physical layer is crucial. Digital twin (DT) modeling, which relies on continuous learning with real-time data, provides a new paradigm to build a virtual replica of the physical layer with a significant improvement in accuracy and reliability. In addition, DT models will be able to forecast future change by analyzing historical data. In this tutorial, we introduce and discuss three key technologies, including modeling, telemetry, and self-learning, to build a DT for optical networks. The principles and progress of these technologies on major impairments that affect the quality of transmission are presented, and a discussion on the remaining challenges and future research directions is provided.
Desperately seeking simplicity (2006)

A surprisingly high percentage of assistive technology devices (35% or more) are purchased, but not successfully adopted. Through semi-structured interviews with a dozen families, we have come to understand the role technology plays in the lives of families who have a young adult with cognitive disabilities, and how families find, acquire, and use these technologies. This study addresses gaps in existing research and informs future efforts in assistive technology design. Design implications include the importance of simplicity not only in technology function but in configuration, documentation, maintenance, and upgrade or replacement; as well as the need for designers to use methods that consider the multiple individuals and stages involved in the technology adoption process.
High resolution, on-line identification of strains from the Mycobacterium tuberculosis complex based on tandem repeat typing (2002)

Tandem-repeat typing is a PCR-based assay which may prove to be a powerful complement to the existing epidemiological tools for the M. tuberculosis complex. The number of markers to type depends on the identification precision which is required, so that identification can be achieved quickly at low cost in terms of consumables, technical expertise and equipment.
Secretion and gene expression of secretory leukocyte protease inhibitor by human airway submucosal glands (2001)

Submucosal glands were isolated within 4 h of death from tracheae and bronchi obtained from autopsied lungs, and the secretory response of secretory leukocyte protease inhibitor (SLPI) was examined with ELISA and a secretory index. Although human neutrophil elastase (HNE) at low concentrations increased SLPI secretion above the control level (i.e., 149% of control level at 10(-11) M), HNE at high concentrations significantly decreased it below the control level (i.e., 16% of control level at 10(-7) M). The decrease in SLPI concentration was shown to result from the degradation of SLPI by excessive HNE. Methacholine induced significant secretion (i.e., 363% of control level at 10(-5) M) that was abolished by both M(1) and M(3) receptor antagonists. A semiquantitative analysis of SLPI mRNA by RT-PCR and Southern blot showed that compared with the superficial epithelium, submucosal glands had a 30-fold or higher level of SLPI mRNA. Both HNE and methacholine significantly increased the level of SLPI mRNA in submucosal glands in a dose-dependent manner (i.e., 357% of control level at 10(-7) M and 175% of control level at 10(-5) M, respectively). These findings indicate that human airway submucosal glands can transcribe 30-fold or more SLPI mRNA than the superficial epithelium and that SLPI mRNA transcription and secretion are regulated by both HNE and muscarinic receptors.