gebhart/patrepeval huggingface dataset:
Optimized inversion‐time schedules for quantitative T1 measurements based on high‐resolution multi‐inversion EPI (2017)

Optimized slice orderings allow faster quantitative T<sub>1</sub> mapping. The optimized sequence yielded accurate and precise T<sub>1</sub> maps. Magn Reson Med 79:2101-2112, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Can a Hexapole magnet of an ECR Ion Source be too strong? (1999)

Abstract: Experience of many ECRIS designers and users during more than a decade has given a few experimental rules, or "scaling laws". Many of these have been discussed at the ECRIS workshops. After the 1993 workshop it was concluded that the properties of the magnetic trap, in particular the strength of the radial component, determine to a great deal the confinement characteristics. For that reason it was decided at the KVI to choose a very strong magnet for the new 14 GHz ECRIS4 to be used in the Atomic Physics experiments. The hexapole magnet designed by the Giessen group is a good example. The induction, measured 2.5 mm inside the pole tips (i.e. at the wall of the plasma chamber) amounts more than 1.2 T. The measured radial field component Br obeys closely the expression Br= 0.00136 r2. (with B in T, r in mm). The quality of the magnetic trap can be given by the "radial mirror ratio", which is usually defined as R = Bmax / Breson, with Breson equal 0.5 T for a 14 GHz ECRIS. For the KVI magnet this would give R= 2.4 . This hexapole magnet was installed in ECRIS4, which is in operation since 1996. ECRIS4 is to a large extent a copy of ECRIS3 at KVI; the main difference is that the hexapole magnet of ECRIS3 has a considerably lower mirror ratio, i.e. R = 1.86. ECRIS3 is in operation since 1995; its performance has been reported at the 1995 ECRIS workshop. It turns out that the source with the stronger magnet produces much lower currents of highly charged ions. Various changes were made in the source set-up, including major alterations of the (axial) magnet configuration. The results of some of these changes, in terms of O7+ and Ar14+ currents, will be discussed. One conclusion could be that, at the given RF frequency of 14 GHz, the strong hexapole magnet forms a basic limitation, because of the smaller ECR volume. At present this conclusion may seem obvious, but that was certainly not the case after the 1993 ECRIS workshop.
The challenge of valve surgery in a developing population. (1993)

Between August 1988 and October 1992, 1,052 patients underwent 1,522 valve procedures in our institution. Their mean age was 32.69 years (range 1-90). The etiology was rheumatic in 724 (68.8%), congenital in 120 (11.4%), degenerative in 99 (9.4%), infective in 58 (5.5%) and ischemic in 17 (1.6%). The mean preoperative functional class (NYHA) was 2.95 and 780 (74.1%) were in sinus rhythm. Repair was possible in 885 (58.1%) valves. The rate of repair versus replacement was 94.5% for the tricuspid, 56.2% for the mitral and 43.6% for the aortic valve. The total hospital mortality was 4.18%. For isolated mitral surgery it was 2.94%, for isolated aortic 4.12% and for isolated tricuspid 15%. Double valve surgery carried a mortality of 3% and triple valve surgery 13%. Hospital mortality for isolated mitral and isolated aortic surgery was lower for repair than for replacement (1.5% vs. 5% and 0 vs. 6.8%). The follow-up was 94.65% complete. The total incidence of embolic events was 2.93% with an actuarial freedom at 48 months of 92.71 +/- 5.35% for repair, 88.22 +/- 6.26% for replacement and 90.31 +/- 5.65% for patients with repair and replacement. Late mortality was 4.5%. The actuarial survival excluding hospital deaths was 94.89 +/- 2.10% for repair, 86.84 +/- 2.84% for replacement and 91.33 +/- 2.73% for the mixed group. The reoperation rate was higher for repair (13%) than for replacement (0.1%). This rate was highest for the rheumatic mitral patients with an age below 20 years (25.2%).(ABSTRACT TRUNCATED AT 250 WORDS)
Transient responses of melatonin to stress (2022)

Melatonin and its metabolites are ubiquitous antioxidants that are produced&#x0D; in response to reactive oxygen species (ROS) in virtually all cells of the&#x0D; body. The highest reported melatonin values in plasma and sweat occur during&#x0D; heavy exercise both indoors and outdoors during the day. The advent of sweat&#x0D; biosensors with sufficient melatonin sensitivity provides pseudo real-time&#x0D; evidence that melatonin is produced throughout the body not just in the pineal&#x0D; gland. The role of the pineal gland appears to be to provide cyclic production&#x0D; of melatonin for the regulation of circadian rhythms as well as supplemental melatonin&#x0D; during periods of low cellular activity. &#x0D; Melatonin from the pineal gland represents only a small fraction of the&#x0D; body’s production capacity. Greater than 5 pg/ml min ramp rates for plasma and&#x0D; sweat melatonin have been reported during strenuous exercise in sunlight as&#x0D; compared to 0.15 pg/ml min ramp rates for plasma melatonin under dim light&#x0D; melatonin onset (DLMO) conditions. Sunlight&#x0D; and exercise, like fever, generates transient elevated levels of ROS in tissues&#x0D; with time constants measured in minutes or even seconds making this systemic&#x0D; antioxidant response potentially protective. Based on a simple accounting of&#x0D; ROS generated by sunlight, ROS we breathe, ROS we drink, and exercise, it&#x0D; appears that the body maintains a heightened basal level of ROS as part of its&#x0D; pathogen defense mechanisms. Current&#x0D; human lifestyles and modern enclosed spaces have substantially eliminated over&#x0D; 90% of the ROS which undermines one of the body’s primary defenses. With&#x0D; advanced age, the inability to maintain this protective barrier appears to make&#x0D; us more susceptible to disease.
MAJOR HISTOCOMPATIBILITY COMPLEX LOCATED COMPLEMENT C4 AND STEROID 21‐HYDROXYLASE GENE REARRANGEMENTS IN COUPLES WITH RECURRENT SPONTANEOUS ABORTIONS (1992)

Major Histocompatibility Complex (MHC) class III located complement C4 and steroid 21-hydroxylase (21OH) genes, which form various deletion and duplication units, were studied by TaqI Restriction Fragment Length Polymorphism (RFLP) in 58 Finnish couples who suffered recurrent spontaneous abortions (RSA). The gene rearrangements found in the RSA couples did not differ from those in the controls.
Computing minimal models, stable models and answer sets (2006)

We propose and study algorithms to compute minimal models, stable models and answer sets of $t$ -CNF theories, and normal and disjunctive $t$ -programs. We are especially interested in algorithms with non-trivial worst-case performance bounds. The bulk of the paper is concerned with the classes of 2- and 3-CNF theories, and normal and disjunctive 2- and 3-programs, for which we obtain significantly stronger results than those implied by our general considerations. We show that one can find all minimal models of 2-CNF theories and all answer sets of disjunctive 2-programs in time $O(m1\mbox{.}4422\mbox{..}^n)$ . Our main results concern computing stable models of normal 3-programs, minimal models of 3-CNF theories and answer sets of disjunctive 3-programs. We design algorithms that run in time $O(m1\mbox{.}6701\mbox{..}^n)$ , in the case of the first problem, and in time $O(mn^2 2\mbox{.}2782\mbox{..}^n)$ , in the case of the latter two. All these bounds improve by exponential factors the best algorithms known previously. We also obtain closely related upper bounds on the number of minimal models, stable models and answer sets a $t$ -CNF theory, a normal $t$ -program or a disjunctive $t$ -program may have.
Concurrent reconfigurable architecture for mapping and encrypting a message in Elliptic Curve Cryptography (2013)

Elliptic Curve Cryptography (ECC) over a Galois Field GF(2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sup> ) offers a high security level relative to other protocols (i.e., RSA) but with smaller keys' sizes. In this paper, we consider the finite field multiplication and addition used in elliptic curve cryptography to design sequential, and then, concurrent reconfigurable ecrypto system to encrypt and decrypt a message. FPGA implementation via VHDL language has been completed to analyze the time and area required in both scenarios. Our approach, and for the first time, consider mapping a message on the elliptic curve concurrently.
Angiotensin-(1-7)/Mas receptor as an antinociceptive agent in cancer-induced bone pain (2016)

Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced inflammation, rapid bone degradation, and disease progression. Opioids are prescribed to manage this pain, but they may enhance bone loss and increase tumor proliferation, further compromising patient quality of life. Angiotensin-(1-7) (Ang-(1-7)) binds and activates the Mas receptor (MasR). Angiotensin-(1-7)/MasR activation modulates inflammatory signaling after acute tissue insult, yet no studies have investigated whether Ang-(1-7)/MasR play a role in CIBP. We hypothesized that Ang-(1-7) inhibits CIBP by targeting MasR in a murine model of breast CIBP. 66.1 breast cancer cells were implanted into the femur of BALB/cAnNHsd mice as a model of CIBP. Spontaneous and evoked pain behaviors were assessed before and after acute and chronic administration of Ang-(1-7). Tissues were collected from animals for ex vivo analyses of MasR expression, tumor burden, and bone integrity. Cancer inoculation increased spontaneous pain behaviors by day 7 that were significantly reduced after a single injection of Ang-(1-7) and after sustained administration. Preadministration of A-779 a selective MasR antagonist prevented this reduction, whereas pretreatment with the AT2 antagonist had no effect; an AT1 antagonist enhanced the antinociceptive activity of Ang-(1-7) in CIBP. Repeated Ang-(1-7) administration did not significantly change tumor burden or bone remodeling. Data here suggest that Ang-(1-7)/MasR activation significantly attenuates CIBP, while lacking many side effects seen with opioids. Thus, Ang-(1-7) may be an alternative therapeutic strategy for the nearly 90% of patients with advanced-stage cancer who experience excruciating pain.
Implication of Enhancer of Zeste Homolog 2 in Pulmonary Arterial Hypertension (2019)

<b>Background:</b> Pulmonary arterial hypertension (PAH) is characterized by persistent elevation of pulmonary arterial (PA) pressure due to excessive proliferation and resistance to apoptosis of PA smooth muscle cells (PASMCs). Right ventricular (RV) failure is the cause of mortality associated with PAH, and is associated with maladaptive RV remodeling and fibrosis. Although epigenetic modifications are increasingly appreciated as an important contributing factor of PAH development, the precise mechanisms remain to be elucidated. EZH2 is a histone methyltransferase that is overexpressed in many cancers promoting cell proliferation and survival. <b>Aim:</b> Study the role of EZH2 in PAH progression. <b>Methods and Results:</b> Using Western blot (WB), we demonstrated that EZH2 is overexpressed in lungs, distal PAs and isolated PASMCs from PAH patients (p&lt;0.01) as well as in the monocrotaline (MCT) and Sugen/Hypoxia rat models (p&lt;0.05). Pharmacological or molecular inhibition of EZH2 leads to reduced PAH-PASMC proliferation (Ki67 labeling and EdU assay, p&lt;0.001) and resistance to apoptosis (Annexin V assay p&lt;0.001). These effects were accompanied by the expression changes of proteins associated with metabolism. In addition, we found that EZH2 is increased in human compensated RV but was decreased in PAH patients with decompensated RV failure (WB, p&lt;0.05). Similar results were found in the MCT model in which the progression of RV remodeling was divided into 4 stages based on hemodynamic data. <b>Conclusion:</b> We demonstrated that EZH2 is implicated in PAH. Further research is required to understand precisely the role of EZH2 in lung and cardiac remodeling in the setting of PAH.
Components for 100G Coherent Pluggable Modules – CFP2 (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. Khatana, "Components for 100G Coherent Pluggable Modules – CFP2," in Optical Fiber Communication Conference, OSA Technical Digest (online) (Optica Publishing Group, 2016), paper Th3G.5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The Ins and Outs of Protein Kinase C (2003)

The seminal discovery of protein kinase C (PKC) by Nishizuka and co-workers (1) in the late 1970s provided the first chapter in the story of one of the most studied enzymes in biology. The subsequent finding that PKC transduces signals that cause lipid hydrolysis, followed shortly thereafter by the discovery that PKC was the long sought-after receptor for the potent tumor-promoting phorbol esters, catapulted PKC to the forefront of research on signal transduction. More than 35,000 research articles have been published on PKC. An abundance of reviews describe the structure, regulation, and biological function of PKC and the interested reader is referred to these for a more detailed overview than the brief one provided below (1–11). The goal of this volume is to present a lab manual on classic and novel techniques that are currently used for studying PKC.
PDK1 disruptors and modulators: a patent review (2015)

Many academic institutions and pharmaceutical companies continue to research into the development of small molecules that can function as PDK1 inhibitors or modulators. To date, >50 patent publications on PDK1 disruptors and modulators have been published since the protein was first discovered in 1998. Most of these molecules act as ATP mimetics, forming similar hydrogen bonding patterns to PDK1 as ATP and functioning as hydrophobic pharmacophores. To achieve selectivity in PDK1 inhibition, the discovery of binding pockets structurally distinctive from the ATP site is a challenging but promising strategy.
Development and commissioning of a multileaf collimator model in Monte Carlo dose calculations for intensity‐modulated radiation therapy (2006)

A multileaf collimator (MLC) model, "MATMLC," was developed to simulate MLCs for Monte Carlo (MC) dose calculations of intensity-modulated radiation therapy (IMRT). This model describes MLCs using matrices of regions, each of which can be independently defined for its material and geometry, allowing flexibility in simulating MLCs from various manufacturers. The free parameters relevant to the dose calculations with this MLC model included MLC leaf density, interleaf air gap, and leaf geometry. To commission the MLC model and its free parameters for the Varian Millennium MLC-120 (Varian Oncology Systems, Palo Alto, CA), we used the following leaf patterns: (1) MLC-blocked fields to test the effects of leaf transmission and leakage; (2) picket-fence fields to test the effects of the interleaf air gap and tongue-groove design; and (3) abutting-gap fields to test the effects of rounded leaf ends. Transmission ratios and intensity maps for these leaf patterns were calculated with various sets of modeling parameters to determine their dosimetric effects, sensitivities, and their optimal combinations to give the closest agreement with measured results. Upon commissioning the MLC model, we computed dose distributions for clinical IMRT plans using the MC system and verified the results with those from ion chamber and thermoluminescent dosimeter measurements in water phantoms and anthropomorphic phantoms. This study showed that the MLC transmission ratios were strongly dependent on both leaf density and the interleaf air gap. The effect of interleaf air gap and tongue-groove geometry can be determined most effectively through fence-type MLC patterns. Using the commissioned MLC model, we found that the calculated dose from the MC system agreed with the measured data within clinically acceptable criteria from low- to high-dose regions, showing that the model is acceptable for clinical applications.
A rigorous and customizable framework for privacy (2012)

In this paper we introduce a new and general privacy framework called Pufferfish. The Pufferfish framework can be used to create new privacy definitions that are customized to the needs of a given application. The goal of Pufferfish is to allow experts in an application domain, who frequently do not have expertise in privacy, to develop rigorous privacy definitions for their data sharing needs. In addition to this, the Pufferfish framework can also be used to study existing privacy definitions.
Séparation d'un copolymère greffé de l'homopolymère correspondant par la méthode des gels réversibles, 2. Application aux résines ABS (1973)

Abstract Une nouvelle technique, basée sur la formation de gels réversibles, est proposée pour la séparation de copolymères greffés, spécialement dans le cas des ABS (acrylonitrile, butadiène, styrène). Par carboxylation du polybutadiène une réticulation réversible peut être obtenue par associations dipolaires des groupes COOH salifiés par un composé d'un métal monovalent (ex.: CH 3 ONa). Dans ces conditions, des séparations sol‐gel permettent d'isoler rapidement le copolymère greffé du polymère non fixé sur le polybutadiène. L'efficacité de la méthode a été montrée pour 4 ABS différents, en utilisant comme traceur un copolymère AS radioactif. Le copolymère greffé, isolé après 3 séparations successives sol‐gel, ne contient plus qu'une proportion d'AS non greffé variant de 0,03% à 0,85%, suivant les ABS analysés. Cette méthode, qui présente l'avantage de pouvoir mettre en évidence des taux de greffage faibles, permet d'aborder l'étude cinétique des greffages, notamment aux taux de conversion faibles. Ce principe de séparation peut être appliqué à d'autres systèmes, à condition de pouvoir fixer sélectivement avant ou après greffage, des groupes COONa sur le polymère tronc ou le polymère formant les greffons.
Polarization insensitive wavelength selective switch using LCOSs and monolithically integrated multi-layered AWG (2010)

We successfully demonstrated signal switching using an LCOS-based wavelength selective switch which had a monolithically integrated multi-layered AWG. The polarization dependent loss of less than 1 dB was obtained around the central channel in C-band.
Customized Versus Noncustomized Sound Therapy for Treatment of Tinnitus: A Randomized Crossover Clinical Trial (2017)

Customized sound therapy can decrease the loudness and THI scores of tinnitus patients, and the results may be superior to broadband noise.
LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling (2016)

Long intergenic noncoding RNAs (lincRNAs) are long noncoding transcripts (>200 nt) from the intergenic regions of annotated protein-coding genes. One of the most highly induced lincRNAs in macrophages upon TLR ligation is lincRNA-Cox2, which was recently shown to mediate the activation and repression of distinct classes of immune genes in innate immune cells. We report that lincRNA-Cox2, located at chromosome 1 proximal to the PG-endoperoxide synthase 2 (Ptgs2/Cox2) gene, is an early-primary inflammatory gene controlled by NF-κB signaling in murine macrophages. Functionally, lincRNA-Cox2 is required for the transcription of NF-κB-regulated late-primary inflammatory response genes stimulated by bacterial LPS. Specifically, lincRNA-Cox2 is assembled into the switch/sucrose nonfermentable (SWI/SNF) complex in cells after LPS stimulation. This resulting lincRNA-Cox2/SWI/SNF complex can modulate the assembly of NF-κB subunits to the SWI/SNF complex, and ultimately, SWI/SNF-associated chromatin remodeling and transactivation of the late-primary inflammatory-response genes in macrophages in response to microbial challenge. Therefore, our data indicate a new regulatory role for NF-κB-induced lincRNA-Cox2 as a coactivator of NF-κB for the transcription of late-primary response genes in innate immune cells through modulation of epigenetic chromatin remodeling.
Supplementary Figure 1 from The Chemopreventive Effect of Mifepristone on Mammary Tumorigenesis Is Associated with an Anti-invasive and Anti-inflammatory Gene Signature (2023)

&lt;p&gt;PDF file - 287K, IHC and western data&lt;/p&gt;
Titelbild (2001)

Das Titelbild zeigt das Metalloporphyrinheterodimer [(tpp)MoRe(oep)]+ mit der neuartigen [MoRe]5+-Einheit. Es handelt sich hier um die erste Vierfachbindung zwischen Elementen aus verschiedenen Triaden, womit bewiesen ist, dass Vierfachbindungen zwischen unterschiedlichen Metallen nicht auf die Metalle der Gruppe 6 beschränkt sind. Am Kalottenmodell wird deutlich, dass die stabilisierenden Porphyrinliganden nicht wechselwirken. Die ORTEP-Darstellung mit Blick entlang der Re-Mo-Achse unterstreicht die perfekt ekliptische Anordnung der Porphyrinliganden, was zweifelsfrei das Vorliegen der Vierfachbindung im Festkörper belegt. Der Diamagnetismus und die große magnetische Anisotropie des Kations, beide 1H-NMR-spektroskopisch nachgewiesen, sprechen dafür, dass die Vierfachbindung auch in Lösung erhalten bleibt. Ein logischer und sauber definierter Syntheseweg führte zu diesem Dimer, und er sollte sich auch zur Synthese anderer Metalloporphyrine mit neuartigen Vierfachbindungen eignen (das Bild wurde von Marina Boulan, St. Petersburg, Russland, gestaltet). Einzelheiten finden sich im Beitrag von J. P. Collman et al. auf S. 1311 ff.
Interval laparoscopic appendectomy for appendicitis complicated by pylephlebitis. (2006)

Similar treatment of other children with this rare presentation seems reasonable.
ChemInform Abstract: γ‐Methylidene‐δ‐valerolactones: New Reagents for Palladium‐Catalyzed Intermolecular Cyclization Reactions (2012)

Abstract Review: 92 refs.
DNA: A-, B-, and Z- (2007)

The sections in this article are 1 Introduction 2 Basic Features of NMR Spectra of DNA 3 Assignments of DNA Spectra 4 Couplings and Conformation 5 Motion and Hydration 6 Summary 7 Biographical Sketch Related Articles
Numerical model of solar dynamic radiator for parametric analysis (2003)

Extensive thermal and power cycle modeling have been developed for Space Station Freedom electric power system design and analysis. A simple and flexible numerical model simulates heat transfer and fluid flow performance of the radiator and calculates area, mass, and impact survivability for many combinations of flow tube and panel configurations, fluid and material properties, and environmental and cycle variations. A brief description and discussion are presented of the numerical model, its capabilities and limitations, and results of the parametric studies performed to date.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Raw reads from Kocuria sp. str. UCD-OTCP genome sequencing project (2013)

Raw paired-end 160bp Illumina MiSeq reads from genomic sequencing of Kocuria sp. str. UCD-OTCP
Theory of surfactant (Sb) induced reconstructions on InP(001) (2003)

Surface structure is an important key to understanding surfactant mechanisms. Surface energies obtained via first principles can help determine the likely reconstructions of clean and surfactant covered surfaces. A general method for calculating accurate zero-temperature surface energies of arbitrarily complex material systems is discussed. Some common sources of error are systematically avoided. The resulting surface energies allow the construction of surface phase diagrams that illustrate surfactant induced changes to the surface. We have applied the described method to the Sb/InP(001) surface and created a surface phase diagram for this material. This diagram and our previously reported results for the GaP(001) surface are helpful in explaining bulk triple period ordering in GaInP and experimentally observed changes in surface structure.