gebhart/patrepeval huggingface dataset:
Dynamic random replication for data centric storage (2010)

This paper presents a novel framework for Data Centric Storage in a wireless sensor and actor network that enables the use of a randomly-selected set of data replication nodes which also change over the time. This allows reducing the average network traffic and energy consumption by adapting the number of replicas to applications' traffic, while balancing energy burdens by varying their location. To that end we propose and validate a simple model to determine the optimal number of replicas, in terms of minimizing average traffic/energy consumption, from the measured applications' production/consumption traffic. Simple protocols/mechanisms are proposed to decide when the current set of replication nodes should be changed, to enable new applications and sensor nodes to efficiently bootstrap into a working sensor network, to recover from failing nodes, and to adapt to changing conditions. Extensive simulations demonstrate that our approach can extend a sensor network's lifetime by at least a 60%, and up to a factor of 10x depending on the lifetime criterion being considered.
Multiple Regions of Internalin B Contribute to Its Ability to Turn on the Ras-Mitogen-activated Protein Kinase Pathway (2003)

Internalin B (InlB) is a protein present on the surface of Listeria monocytogenes that mediates bacterial entry into mammalian cells. It is thought that InlB acts by binding directly to the hepatocyte growth factor (HGF) receptor, present on the surface of host cells. Binding of InlB to the HGF receptor results in mitogen-activated protein (MAP) kinase and phosphoinositide 3-kinase activation, followed by changes in the organization of the actin cytoskeleton. Here we have compared signaling by HGF and InlB. Whereas stimulation with equivalent concentrations of HGF and InlB elicits similar activation of the HGF receptor, we observed striking differences in downstream activation of MAP kinase. InlB leads to a greater activation of the Ras-MAP kinase pathway than does HGF. The leucine-rich repeat region, which was previously shown to be sufficient for binding and activation of the HGF receptor, lacks the ability to super-activate the Ras-MAP kinase pathway. Analysis of a series of deletion mutants suggests that it is the B repeat region between the leucine-rich repeat and GW domains that endows InlB with an increased ability to turn on the Ras-MAP kinase pathway. These unexpected observations suggest that HGF and InlB use alternative mechanisms to turn on cellular signaling pathways.
Combination Chemotherapy with Clostridium perfringens Phospholipase C and Cytosine Antimetabolites: Complementary Inhibition Directed at Membrane Lipids (1983)

Tumor cell membranes were susceptible to the action of Clostridium perfringens phospholipase C, and this was reflected by inhibition of cellular replication in culture. The differential susceptibility of two neoplastic cell lines to this enzyme was studied in detail. The growth of sarcoma 180 cells cultured in Fischer's medium was markedly inhibited by phospholipase C; whereas, in contrast, cultured L1210 leukemia cells were relatively resistant to the cytotoxic effects of this enzyme. The differential sensitivity of these two neoplastic cell lines to phospholipase C was corroborated by dye-exclusion tests. Thus, leukemia L1210 cells exposed to a concentration of 0.2 mg of phospholipase C per ml of Fischer's medium for 30 min at 37 degrees C were able to exclude Trypan Blue; whereas, only about 21% of sarcoma 180 cells treated under identical conditions were able to exclude the dye. That the cytotoxicity of phospholipase C to sarcoma 180 was the result of hydrolysis of phospholipids of the plasma membrane was supported by measurements of the rate of hydrolysis of radioactivity from the phospholipid of neoplastic cells prelabeled with [3H]choline. Eighty-two percent of incorporated radioactive choline was released from sarcoma 180 cells treated with phospholipase C in Fischer's medium, whereas, only 20% of the label from [3H]choline was solubilized from L1210 leukemia cells treated with the enzyme under similar conditions. Scanning electron microscopy revealed significant damage to sarcoma 180 cells exposed to phospholipase C in Fischer's medium, which was characterized by alterations in size and shape of cells, disappearance of microvilli, and appearance of fistulas in cell membranes; relatively resistant L1210 leukemic cells did not appear to be markedly damaged by comparable enzyme treatment. Exposure of leukemia L1210 cells to phospholipase C in Puck's saline A increased the sensitivity of these cells to enzymatic action. Under these conditions, a comparable amount of phospholipid was hydrolyzed from surface membranes of sarcoma 180 and leukemia L1210 cells, and the degree of membrane damage appeared to be similar, as measured by the capacity of the tumor cell lines to exclude Trypan Blue and by scanning electron microscopy. The extensive damage to membranes by hydrolysis of phospholipids was not accompanied by a change in the degree of specific binding of [3H]concanavalin A(ConA).(ABSTRACT TRUNCATED AT 400 WORDS)
Neural Word Embedding as Implicit Matrix Factorization (2014)

We analyze skip-gram with negative-sampling (SGNS), a word embedding method introduced by Mikolov et al., and show that it is implicitly factorizing a word-context matrix, whose cells are the pointwise mutual information (PMI) of the respective word and context pairs, shifted by a global constant. We find that another embedding method, NCE, is implicitly factorizing a similar matrix, where each cell is the (shifted) log conditional probability of a word given its context. We show that using a sparse Shifted Positive PMI word-context matrix to represent words improves results on two word similarity tasks and one of two analogy tasks. When dense low-dimensional vectors are preferred, exact factorization with SVD can achieve solutions that are at least as good as SGNS's solutions for word similarity tasks. On analogy questions SGNS remains superior to SVD. We conjecture that this stems from the weighted nature of SGNS's factorization.
Effects of alkyl chain length on the thermodynamics of proton ionization from arsonic and arsinic acids (1976)

ΔG°, ΔH°, and ΔS° values are reported for the two proton ionizations from several n-alkylarsonic acids (methyl, ethyl, propyl, butyl, pentyl, and hexyl) and from several protonated di-n-alkylarsinic acids (methyl, ethyl, propyl, butyl, and pentyl) in aqueous solution at 25°. The ΔG° values were determined from pH measurements, and the ΔH° values were determined calorimetrically. The variations in ΔG°, ΔH°, and ΔS° with alkyl chain length found for both the arsonic and arisinic acid ionizations differ from hydrocarbon chain lengthening effects on the thermodynamics of proton ionization previously reported for protonated amines, protonated amino-acids, and carboxylic acids.
Hybrid RANS/LES Simulation of Corner Stall in a Linear Compressor Cascade (2017)

Current design-cycle Reynolds-Averaged Navier-Stokes-based CFD methods have the tendency to over-predict corner-stall events for axial-flow compressors operating at off-design conditions. This shortcoming has been demonstrated even in simple single-row cascade configurations [1]. Here we report on the application of hybrid RANS/LES predictions for simulating the corner-stall data from the linear compressor cascade work conducted at Ecole Centrale de Lyon [2][3][4]. This benchmark data set provides detailed loss information while also revealing a bimodal behavior of the separation which, not surprisingly, is also not well modeled by RANS. The hybrid RANS/LES (or DES) results presented here predict bimodal behavior similar to the data only when special treatment is adopted to resolve the leading-edge endwall region where the horseshoe vortex forms. The horseshoe vortex is shown to be unstable, which produces the bimodal instability. The DES simulation without special treatment or refinement in the horseshoe vortex region fails to predict the bimodal instability, and thus the bimodal behavior of the separation. This in turn causes a gross over-prediction in the scale of the corner-stall. The horseshoe vortex region is found to be unstable with rolling of the tertiary vortex over the secondary vortex and merging with the primary horseshoe vortex. With these flow dynamics realized in the DES simulations, the corner stall characteristics are found to be in better agreement with the experimental data, as compared to RANS and standard DES approaches.
A 15q24 microdeletion in transient myeloproliferative disease (TMD) and acute megakaryoblastic leukaemia (AMKL) implicates PML and SUMO3 in the leukaemogenesis of TMD/AMKL (2012)

Transient myeloproliferative disorder (TMD) of the newborn and acute megakaryoblastic leukaemia (AMKL) in children with Down syndrome (DS) represent paradigmatic models of leukaemogenesis. Chromosome 21 gene dosage effects and truncating mutations of the X-chromosomal transcription factor GATA1 synergize to trigger TMD and AMKL in most patients. Here, we report the occurrence of TMD, which spontaneously remitted and later progressed to AMKL in a patient without DS but with a distinct dysmorphic syndrome. Genetic analysis of the leukaemic clone revealed somatic trisomy 21 and a truncating GATA1 mutation. The analysis of the patient's normal blood cell DNA on a genomic single nucleotide polymorphism (SNP) array revealed a de novo germ line 2·58 Mb 15q24 microdeletion including 41 known genes encompassing the tumour suppressor PML. Genomic context analysis of proteins encoded by genes that are included in the microdeletion, chromosome 21-encoded proteins and GATA1 suggests that the microdeletion may trigger leukaemogenesis by disturbing the balance of a hypothetical regulatory network of normal megakaryopoiesis involving PML, SUMO3 and GATA1. The 15q24 microdeletion may thus represent the first genetic hit to initiate leukaemogenesis and implicates PML and SUMO3 as novel components of the leukaemogenic network in TMD/AMKL.
Extrusion of self-reinforced polyethylene (2004)

AbstractAbstractAlong with conventionally extruded rods, self-reinforced polyethylene rods were continuously prepared using a conventional extruder equipped with a converging extrusion die. From the work, it is apparent that the self-reinforced rods showed elastic moduli nearly four times higher than that of conventionally extruded rods. Scanning electron microscopy revealed that the morphology of the self-reinforced rod was fibrous and that the fibrils extended straight along the extrusion direction. Moreover, the self-reinforced rods melted at a higher temperature than the rods which had been prepared conventionally. The extrusion line as designed in this work seems to be suitable for self-reinforcement of polymers.Keywords: POLYETHYLENEEXTRUSIONFLOW-INDUCED CRYSTALLISATIONSELF-REINFORCEMENTFIBROUS STRUCTURE
Spherization of red blood cells and platelets margination in COPD patients (2020)

Abstract Rationale There are important interactions between Red Blood Cells (RBCs) and platelets in the bloodstream. These interactions lead to a phenomenon called margination. RBCs in pathological situations undergo biochemical and conformational changes leading to alterations in blood rheology. Aim RBCs shape in volunteers (21), stable (42) and exacerbated (31) COPD patients was analyzed. We studied the effect of the RBCs spherization on the platelets transport experimentally, in vitro , and by using numerical simulations. Methods RBC shape was estimated by the second moment of Pearson obtained through flow cytometry on fsc histogram. In vitro experiments were performed to analyze the effect of RBC shape on platelets adhesion/aggregation in dynamic conditions. Neuraminidase treatment was used to induce RBCs spherization. Numerical simulation were performed to determine the effect of RBCs spherization on platelets mean square displacement (MSD) to provide a physical explanation. Results Significant increase of RBC sphericity was observed in COPD patients compared to volunteers (Kruskal-Wallis: p&lt;0.0001). In vitro experiments, at shear rate of 100 s -1 , we observed that RBCs treated with neuraminidase mainly affect the number of platelet aggregates (p = 0.004). There was no change in the aggregates size. At a shear rate of 400 sec -1 neuraminidase treatment changes both the size of the aggregates (p = 0.009) and the number of platelet aggregates (p = 0.008). Numerical simulations indicated that RBCs spherization induces an increase of MSD and the effect was more pronounced when the shear rate increased. Conclusion Our results show that the RBCs of COPD patients are more spherical than those of healthy volunteers. Experimentally we observe that the RBCs spherization induces an increase platelet transport to the wall. Additional studies are needed to better understand the possible association between the RBCs effect on the platelets transport and the increased cardiovascular events observed in COPD patients.
Coupling Heatshield Response and Aerothermal Environment for Mars Entry via Surface Gas Blowing (2023)

View Video Presentation: https://doi.org/10.2514/6.2023-0963.vid Flight data obtained using the instrumented heatshields on the Mars Science Laboratory and Mars 2020 has offered unique validation data for material response and aerothermal environment modeling of Mars atmospheric entry. While the environment and material response are coupled in reality, they are usually solved separately with a correction to account for blowing at the surface. The objective of this work is to showcase the coupling of gas blowing between the material response and the aerothermal environment codes. Simulations are iterated until a convergence in surface temperature is obtained. Coupling the material response and environment models may lead to improved fidelity in modeling atmospheric entry and could serve as a validation for decoupled material response and aerothermal environment models.
An Analysis of Hybrid Public Key Encryption (2020)

This analysis is superseded by the more detailed analysis available in “Analysing the HPKE Standard” by J. Alwen, B. Blanchet, E. Hauck, E. Kiltz, B. Lipp, D. Riepel available at https://eprint.iacr.org/2020/1499. This document stays available because 2020/1499 only treats HPKE's Auth mode.
Figure S3 from The Tumor-Suppressor Protein OPCML Potentiates Anti–EGFR- and Anti–HER2-Targeted Therapy in HER2-Positive Ovarian and Breast Cancer (2023)

&lt;p&gt;SKOV3, OV90 and SKBR3 cells were virally transduced to express OPCML&lt;/p&gt;
REACTION OF KETENIMINE AND SULFUR DIIMIDE (1976)

Abstract The reaction of diphenylketene-N-phenylimine (1) and diphenylsulfur diimide (2) gave the 2-aminoindole 4 as a major product together with the benzothiatriazepine 3 and the amidine 5.
Cellulose nanofibrils/silver nanowires suspensions for the development of barrier properties and antibacterial surfaces (2019)

International audience
Heterologous vaccination interventions to reduce pandemic morbidity and mortality: modeling the US winter 2020 COVID-19 wave (2022)

COVID-19 remains a stark health threat worldwide, in part because of minimal levels of targeted vaccination outside high-income countries and highly transmissible variants causing infection in vaccinated individuals. Decades of theoretical and experimental data suggest that nonspecific effects of non–COVID-19 vaccines may help bolster population immunological resilience to new pathogens. These routine vaccinations can stimulate heterologous cross-protective effects, which modulate nontargeted infections. For example, immunization with Bacillus Calmette–Guérin, inactivated influenza vaccine, oral polio vaccine, and other vaccines have been associated with some protection from SARS-CoV-2 infection and amelioration of COVID-19 disease. If heterologous vaccine interventions (HVIs) are to be seriously considered by policy makers as bridging or boosting interventions in pandemic settings to augment nonpharmaceutical interventions and specific vaccination efforts, evidence is needed to determine their optimal implementation. Using the COVID-19 International Modeling Consortium mathematical model, we show that logistically realistic HVIs with low (5 to 15%) effectiveness could have reduced COVID-19 cases, hospitalization, and mortality in the United States fall/winter 2020 wave. Similar to other mass drug administration campaigns (e.g., for malaria), HVI impact is highly dependent on both age targeting and intervention timing in relation to incidence, with maximal benefit accruing from implementation across the widest age cohort when the pandemic reproduction number is &gt;1.0. Optimal HVI logistics therefore differ from optimal rollout parameters for specific COVID-19 immunizations. These results may be generalizable beyond COVID-19 and the US to indicate how even minimally effective heterologous immunization campaigns could reduce the burden of future viral pandemics.
Scintillation Efficiency Improvement by Mixed Crystal Use (2013)

Analysis of the last years theoretical studies and track simulations to conclusion that primary stages (electron scattering and e-h thermalization) play the key role in the following scintillator efficiency. The long thermalization length comparing to Onsager radius is the main reason for geminate pair concentration decrease and later luminescence losses. The easiest way for thermalization length decrease is the scintillation crystal doping or even transfer to the mixed crystals (solid solution). The simple model of modification of electrons scattering and e-h pairs thermalization for the mixed crystals is proposed. It is shown that solid solutions have higher light output independently on the crystal type. Analysis of experimental data confirmed this conclusion. This phenomenon is found for halide, oxide and sulfates scintillators. The similar behavior is typical for mixed anion and/or cation systems. The key role of initial track formation stages is illustrated by the same trend for activated scintillators and pure crystal with intrinsic luminescence. These estimations and experimental data lead to the conclusion that the scintillation efficiency improvement by mixed crystal use can play an important role in the search and development of new scintillators.
Variability of mechanical power output in elite rowers during ergometer testing (2022)

https://www.germanjournalsportsmedicine.com/archiv/archive-2022/issue-2/variability-of-mechanical-power-output-in-elite-rowers-during-ergometer-testing/
Novel Effective Racemoselective Method for the Synthesis of ansa-Zirconocenes and Its Use for the Preparation of C2-Symmetric Complexes Based on 2-Methyl-4-aryltetrahydro(s)indacene as Catalysts for Isotactic Propylene Polymerization and Ethylene–Propylene Copolymerization (2012)

A general and effective method for the racemoselective synthesis of bis-indenyl-type ansa-zirconocenes was proposed and successfully applied for the synthesis of several C2-symmetric ansa-zirconocenes based on 2-methyl-4-aryltetrahydro-s-indacene. This new racemoselective method relies on ZrCl3NH-tert-Bu as a key reagent. The formation of racemic products was confirmed by NMR studies and single-crystal X-ray diffraction. The novel complexes are potent catalysts for isotactic propylene polymerization and ethylene–propylene copolymerization.
Abstract LB-370: Genetically engineered oncolytic Edmonston strain of measles strain harboring the wild-type N, P, L genes (MV-NPL) effectively target lung cancer stem cells (2012)

Abstract Increasing evidence suggests that only a small percentage of cancer cells in solid tumors have tumorigenic potential. These highly tumorigenic cells share with normal stem cells the ability to proliferate and give rise to diversified tumor cell types including those with the capacity for self-renewal. These cells are termed cancer stem cells (CSCs) and are believed to contribute to CSCs resistance to conventional therapies. Therefore, specific targeting of CSCs is an attractive and novel therapeutic approach. Measles virus Edmonston strain (MV-Edm) is thought to possess remarkable oncolytic activity that selectively destroys human tumor cells. Recently, we succeeded and reported the development of novel oncolytic measles virus (MV) by genetic engineering of MV-Edmonston strain (MV-Edm), that have demonstrated its remarkable oncolytic activity against wide ranges of human tumor cells, with the N, P, and L genes of wild-type MV (MV-NPL). The oncolytic activities of the MV-NPL on human renal cell carcinoma were superior to those of MV-Edm both in vitro and in vivo studies even in the presence of IFN[[Unsupported Character - &amp;#8208;]]α[[Unsupported Character - &amp;#61472;]](Xing, M. et. al. Mol Ther 2010). Here, we demonstrated that lung CSCs, side population fraction of human lung cancer cells of A549 (A549-SP), expressed high level of CD46 required for MV-NPL infection and MV-NPL had a superior oncolytic capacity against both A549-SP and A549-NSP (non SP) cells in a time and dose-dependent manner without damaging normal lung cells. Our results of pan-caspase inhibiton assays showed the partial contribution of caspases-dependent apoptosis in the oncolysis of A549-SP cells by MV-NPL, even though the expression levels of anti-apoptotic protein of both XIAP and Mcl-1 were higher in A549-SP cells than A549-NSP cells. Additionally, we demonstrated that an addition of either PI3K inhibitor or MEK inhibitor further enhanced the oncolytic effects of MV-NPL. Furthermore, our in vivo studies using nude mice bearing A549 xenografts revealed that serial intratumoral MV-NPL administrations exhibited significant antitumor effects without severe side effects. Collectively, these data suggested that genetically engineered MV-NPL could be a promising oncolytic agent to effectively eradicate lung CSCs. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-370. doi:1538-7445.AM2012-LB-370
Stereoselective Prostereogenic 3‐Oxo Ester Reduction Mediated by a Novel Yeast Alcohol Dehydrogenase Derived from Kluyveromyces marxianus CBS 6556 (2007)

Abstract A yeast alcohol dehydrogenase (ADH) has been purified up to a purification factor value of 21,731‐fold from Kluyveromyces marxianus CBS 6556. The purification procedure consisted of two chromatographic steps (DEAE‐anion exchange and affinity chromatography). The optimal pH was 7, its optimal temperature was 40 °C and its co‐factor was NADPH. This novel ADH efficiently mediated the reduction of 3‐oxo esters with a high degree of stereoselectivity, providing chiral alcohols having the ( S ) absolute configuration at the newly formed stereogenic centre by delivering the hydride from the re ‐face of the prochiral carbonyl compounds.
Audiences of Seattle Men's Chorus and Seattle Women's Chorus as Seen in Network Graphing (2012)

For this project, we wanted to analyze the relationships of audience members of the Seattle Men?s Chorus and Seattle Women?s Chorus to one another. Using data provided by the organization, we were able to analyze which concerts were more popular amongst individual audience members. We wanted to find the answers to the following questions. Are there particular audience members that frequently attend concerts? Also, which ZIP codes contain the highest concentration of audience members? As a gay chorus, would ticket sales be concentrated in ZIP codes with higher-than average numbers of same-sex heads of household? Using Network Graphing analysis, the study supplies answers to these questions.
Reconsidering fragmentation and reassembly (1998)

links often have different maximum packet sizes. Thus most network protocols allow large packets to be fragmented in order to be carried over a link with a small maximum packet size. The fragments are then reassembled either at the next hop or at the destination to recreate the original packet.