gebhart/patrepeval huggingface dataset:
CSF synuclein: adding to the biomarker footprint of dementia with Lewy bodies (2010)

Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia disorder. Lack of awareness, frequent misdiagnosis and its poorly understood pathogenesis represent key impediments to improved care. A related challenge is the overlap between DLB and Alzheimer's disease (AD). Applying currently available clinical guidelines, DLB is a well-defined dementia with high specificity but low sensitivity,1 thereby highlighting the need for validated biomarkers.

The quantification of neural proteins in cerebrospinal fluid (CSF) for biomarker purposes has received enormous impetus from the AD field. AD is characterised by β-amyloidosis and tauopathy. In accordance, measurements of CSF β-amyloid and τ have become important in the early and differential diagnoses of dementia. …
Cryptogenic Organizing Pneumonia (2012)

Organizing pneumonia (OP) is a pathological pattern defined by the characteristic presence of buds of granulation tissue within the lumen of distal pulmonary airspaces consisting of fibroblasts and myofibroblasts intermixed with loose connective matrix. This pattern is the hallmark of a clinical pathological entity, namely cryptogenic organizing pneumonia (COP) when no cause or etiologic context is found. The process of intraalveolar organization results from a sequence of alveolar injury, alveolar deposition of fibrin, and colonization of fibrin with proliferating fibroblasts. A tremendous challenge for research is represented by the analysis of features that differentiate the reversible process of OP from that of fibroblastic foci driving irreversible fibrosis in usual interstitial pneumonia because they may determine the different outcomes of COP and idiopathic pulmonary fibrosis (IPF), respectively. Three main imaging patterns of COP have been described: (1) multiple patchy alveolar opacities (typical pattern), (2) solitary focal nodule or mass (focal pattern), and (3) diffuse infiltrative opacities, although several other uncommon patterns have been reported, especially the reversed halo sign (atoll sign). Definitive diagnosis is based on (1) a suggestive clinical radiological presentation, (2) the demonstration of the characteristic pathological pattern at lung histopathology, and (3) exclusion of possible causes. Transbronchial biopsies or a transthoracic biopsy may also contribute to the pathological diagnosis. Rapid clinical and imaging improvement is obtained with corticosteroid therapy. Because of the risk of misdiagnosing alternative conditions that may mimic OP, only typical cases may be managed without histopathological confirmation, and patients should be followed with particular attention paid to any clue of alternate diagnosis, especially in case of incomplete response to treatment. Patients and clinicians must be aware of frequent relapses after stopping corticosteroid treatment.
Tablet-PC erweitert die Maschinenbedienung (2014)

Kostendruck und Dokumentationspflichten sind zentrale Herausforderungen für den Maschineneinsatz bei Lohnunternehmen und Agrarbetrieben. Ein Lösungsansatz besteht in der prozessorientierten Vernetzung aller eingesetzten Maschinen. Die ursprünglich rein funktional ausgelegten Maschinensteuerungen und -bedienungen übernehmen hierbei zunehmend erweiterte Aufgaben aus den Bereichen Auftragsmanagement, Navigation oder Flottenmanagement. Moderne Tablet-PCs können diese Managementaufgaben kostengünstig übernehmen und bieten darüber hinaus eine Vielzahl an Zusatzfunktionen.
Figure S14 from <i>In Vivo</i> Epigenetic CRISPR Screen Identifies <i>Asf1a</i> as an Immunotherapeutic Target in <i>Kras</i>-Mutant Lung Adenocarcinoma (2023)

&lt;p&gt;In vivo F4/80 or GM-CSF blockade attenuates anti-tumor immune response in Asf1a KO and anti-PD-1 combination therapy&lt;/p&gt;
Corticotropin-releasing factor in cerebellar afferent systems: a combined immunohistochemistry and retrograde transport study (1988)

The flocculus and paraflocculus of cat and sheep cerebellum were studied with immunohistochemical methods, using antisera to corticotropin-releasing factor (CRF). CRF immunoreactivity was present within 3 populations of varicose nerve fibers. One population of CRF-immunoreactive (CRF-IR) fibers appeared to appose Purkinje cell somata and to follow their dendrites into the molecular layer. This arrangement suggested they were climbing fibers. A second group of CRF-IR profiles reminiscent of mossy fibers was widely distributed throughout the granule cell layer. A third population of CRF-IR fibers was present as a beaded plexus lying parallel to the pial surface, above and subadjacent to the Purkinje cell layer. The fibers of this plexus extended into the Purkinje cell layer and surrounded these somata. The source of some of the CRF-IR fibers within the flocculus and paraflocculus was determined by a retrograde axonal transport study utilizing the fluorescent tracer Fast blue (FB) in combination with the immunohistochemical localization of CRF. It was determined that CRF-IR perikarya within the inferior olivary nucleus gave rise to a population of climbing fibers within those lobules. Furthermore, all divisions of the inferior olive were found to contain CRF-IR somata. This latter finding suggests the potential for CRF-IR climbing fiber projections from the inferior olive to other regions of the cerebellar cortex. The existence of CRF-IR mossy fibers and fibers within the ganglionic plexus suggests the possibility of CRF-IR afferent projections from other regions of the brain stem to the flocculus and paraflocculus.
Prediction of the space-varying point spread function for reconstruction of anisoplanatic adaptive optics images (2005)

Atmospheric turbulence corrupts astronomical images formed by ground-based telescopes. Adaptive optics (AO) systems allow the effects of turbulence-induced aberrations to be reduced for a narrow field of view (FOV) corresponding approximately to the isoplanatic angle &#952;<sub>0</sub>. For field angles larger than &#952;<sub>0</sub>, the point spread function (PSF) gradually degrades as the field angle increases. In this paper, we present a technique to predict the PSF as function of the field angle. The predicted PSF is compared to the simulated PSF and the mean square (MS) error between the predicted and the simulated PSF never exceeds 2.7%. Simulated anisoplanatic intensity images of a star field are reconstructed by mean of a block-processing method using the predicted PSF. Two methods for image recovery are used: the Tikhonov regularization and the expectation maximization (EM) algorithm. The deconvolution results using the space-varying predicted PSF are compared to deconvolution results using the space-invariant on-axis PSF. The reconstruction technique using the predicted PSF shows an improvement of the MS error between the reconstructed image and the object of 7.2% to 84.8% compared to the on-axis PSF reconstruction.
The value of nature walks (1997)

Since the early days of pre-school provision the natural environment has been a valued part of children's experience and learning. Some practitioners emphasise the contribution of physical exercise and fresh air to health, others the spiritual and creative opportunities presented through a nature walk. Most recently the desirable outcomes advocate that children, by the age of five, should have a ‘developing knowledge and understanding of their environment, other people and features of the natural and made world.’ (Knowledge and Understanding of the World)
Cardiac catheterisation in infants weighing less than 2500 grams (2019)

Cardiac catheterisation in infants weighing &lt;2500 g appears feasible and effective with low risk. The weight should not discourage from performing cardiac catheterisation in this population.
Precipitation of Nanoscale Aluminum Hydroxide Particles (2001)

The precipitation of nanoscale alumina particles from sodium aluminate solutions by dilution and neutralization with water and oxalic acid in the presence of a surface-active polymers polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) is investigated. This study is exploratory as to the use of Bayer liquors as a source of nanoscale alumina and provides some fundamental insights necessary for an understanding of the overall kinetics and mechanisms involved in the precipitation process. The particle sizes are determined by dynamic light scattering (DLS). Scanning electron microscopy is used to image the particles and to determine composition by energy dispersive analysis by X-rays (EDAX). Transmission electron microscopy (TEM) is used to determine primary particle sizes. The alumina particles precipitated in the presence of PVP had diameters of 80 to 300 nm. The alumina precipitated in the presence of PVA had diameters of 200 nm to 1.2 μm. The sizes obtained from DLS experiments do not correlate with increasing supersaturation. DLS of sols prepared using oxalic acid alone without polymer surfactant additive yielded particles with average diameters of 200 to 300 nm. The TEM image of the sols trapped between nitrocellulose membranes shows the particles as nearly spherical, of diameter 176 nm, and not pure alumina as originally expected. These particles have a gel like structure and deform under stress. Dehydration of these particles leads to aggregation of amorphous fibrous particles of aluminum trihydroxides contaminated with sodium.
BANKART PROCEDURE: CLINICAL AND RADIOLOGICAL LONG-TERM OUTCOME (2002)

Purpose of the study: There are few reports onlong-term outcome after Bankart procedure. The purpose of this study was to determine the rate of recurrent dislocation, the clinical results and the incidence of glenohumeral osteoarthritis after a minimum 10-year follow-up. Material and methods: Ninety-seven Bankart procedures were performed in 97 patients between 1972 and 1986 for treatment of anterior shoulder instability with recurrent dislocations. We retrospectively reviewed 74 patients and obtained 64 complete radioclinical evaluations for an average follow-up of 16 years. Clinical evaluation was based on the G. Walch and the Duplay group score but for easier comparisons, we also calculated the Rowe et al. score. Radiographical evaluation was established on the Samilson and Prieto classification but real glenohumeral osteoarthritis with joint narrowing was noted independently as grade four. We also studied the contralateral shoulder. Results: At last follow-up, 7 shoulders (9.5%) had recurrent dislocation, but two of them occurred subsequent to severe trauma over 18 months. Most patients (95%) were satisfied or very satisfied. Six patients (8.1%) had persistent apprehension but in some it was not due to anterior apprehension. According to the Duplay score (or the Rowe score), 25 shoulders (44.6%) had an excellent result (35/61.4%) 16 (28.6%) a good result (7/12.3%), 11 (19.7%) a fair result (11.19.3) and 4 (5.4%) a poor result (4/7%). Operated shoulders were pain free for 75% and painful for forced movements only for 25%. External rotation at 90° of abduction was reduced by 8.7 ± 15.7°. There was no limitation of internal rotation. Patients returned to preoperative sports activities at the same level for 70.9% and at a lower level for 12.7%. According to the Samilson classification, 7 (13%) of the shoulders had grade 2 and 2 (3.7%) had grade 3 glenohumeral osteoarthritis. We found 4 cases (7.4%) of real glenohumeral osteoarthritis (grade four) and 2 of these patients had contralateral osteoarthritis of a non unstable shoulder. There was no perioperative complication. Discussion: In our hands the Bankart procedure is appeared as a safe procedure with a low rate of glenohumeral osteoarthritis and a high rate of patient satisfaction.
Estimation of the Fracture Aperture and Shape Created by Massive Hydraulic Fracturing Test. (1997)

A hydraulic fracturing test was conducted in 1992 at the Hijiori hot dry rock test site. In this test, water was injected into injection well HDR-1. The depth of the injection well was about 2, 200m, and the maximum ternperature of the well was about 270 degC. The main fracture, which was extended along natural joints, was initiated from the bottom hole and a radius of the fracture was estimated to be about 500m from the acoustic emission observation. In this paper, the radius of the fracture, and the pressure, permeability and aperture distribution within the fracture was estimated by numerical simulation. The FEHM (Finite Element Heat and Mass transfer) code was used to estimate the radius of the growing fracture and a pressure distribution within the fracture. The Gangi bed-of-nails model was used to relate the fracture aperture to the fluid pressure. The permeability of the fracture was then calculated from the fracture aperture using Lomize's friction factor. A pressure history match between measured and calculated value was obtained. The simulation result shows that the radius of the fracture at the end of the experiment was about 500m, which agrees well with observations. The estimated apertures of the fracture at the vicinity of the well were 1.4mm and 2.6mm when the injection water rates were kept constant at 6kg/s and 20kg/s, respectively. In this simulation, three fitting parameters were used to match the pressure history. The sensitivities of three parameters on the simulation results were also examined.
Membrane Filter Procedure forEnumerating theComponent Genera oftheColiform GroupinSeawater (1975)

A facile, quantitative, membrane filter procedure (mC)fordefining thedistribution ofcoliform populations inseawater according tothecomponent genera wasdeveloped. Theprocedure, whichutilizes aseries ofinsitu substrate tests toobviate thepicking ofcolonies foridentification, also provides anestimateofthetotal coliform density. Whenpurecultures ofEscherichia coli, Klebsiella pneumoniae, andEnterobacter cloacae weresuspended inseawater andheld at4Cfor24h,between 56and100%ofthecells whichgrewonnutrient agarspread plates at35Ccould berecovered bythemC procedure. Confirmation ascoliforms oftypical colonies fromnatural samples wasabout95%.Assay variability wasfound tobeinsignificant. Therecovery ofcoliforms frommarine waters bythemC procedure wascomparable tothose obtainable bycurrent methods. Klebsiella wasdifferentiated bytheurease reaction andE.coli byits ability toformindole. Theconfirmation frequencies forcolonies designated as Klebsiella andE.coli bytheinsitu tests approached 95%fortheformer and 98%forthelatter. Totalcoliform andfecal coliform densities havebeenusedtoindicate hazardous fecal contamination ofsurface aswellaspotable waters. Thepractice ofusing these twogroups asindicators ofthecontamination ofsurface waters withfecal wastesorsewagehasbeen questioned recently, particularly withregard to thehealth hazard related totheuseofsuch waters(9). Theambiguity arising therefrom derives firstly fromthefact that somecoliform biotypes arewidely distributed innatureand maybeonlytransient inhabitants ofthegastrointestinal tractofwarm-blooded animals; secondly, theability ofsomecoliforms tosimulate thebehavior ofmicrobial pathogens inthe aquatic environment, especially inmarine waters, appears tobeinadequate (13, 21). Theshortcomings notedabovearemainly duetotheheterogeneity ofthecoliform group. Theelevated temperature, fecal coliform test, either bythemost-probable-number estimate orthemembrane filter technique, wasdevelopedtoalleviate these shortcomings. Although fecal coliforms areamorerestricted portion of thetotal coliform population, theytooarea heterogeneous groupcomposed primarily of Escherichia coli andKlebsiella biotypes. More important, aboutone-half oftheKlebsiella isolates obtained fromcertain industrial effluentsfreeoffecal contamination wouldfitthe
The Application of Hybrid Evolving Connectionist Systems to Image Classification (2000)

This paper presents a methodology for image classification of both spatial and spectral data with the use of hybrid evolving fuzzy neural networks (EFuNNS). EFuNNs are five layer sparsely connected networks. EFuNNs contain dynamic structures that evolve by growing and pruning of neurons and connections. EFuNNS merge three supervised classification methods: connectionism, fuzzy logic, and case-based reasoning. By merging these strategies, this new structure is capable of learning and generalising from a small sample set of large attribute vectors as well as from large sample sets and small feature vectors. Two case studies data are used to demonstrate the effectiveness of the methodology. First, an environmental remote sensing application, and second, large scale images of fruit for automated grading. The proposed methodology provides fast and accurate adaptive learning for image classification. It is also applicable for on-line, real-time learning and classification.
Pediatric Laparoscopic Pyeloplasty: 4-Year Experience (2007)

Our series of patients undergoing laparoscopic pyeloplasty had excellent results with low morbidity. We consider this our primary technique for surgical correction of UPJO in patients older than 18 months.
Optimizing a Behavioral Sleep Intervention for Gynecologic Cancer Survivors: Study Design and Protocol (2022)

Sleep difficulties, particularly symptoms of insomnia and circadian disruption, are among the primary complaints of gynecologic cancer survivors before, during, and after treatment. Moreover, difficulty sleeping has been linked to poorer health-related quality of life and elevated symptom burden in this population. Although leading behavioral sleep interventions have demonstrated efficacy among cancer survivors, up to 50% of survivors are non-adherent to these treatments, likely because these interventions require labor-intensive behavior and lifestyle changes. Therefore, there is a need for more effective and acceptable approaches to diminish sleep disturbance among cancer survivors. This manuscript describes the methodology of a two-part study guided by the Multiphase Optimization Strategy (MOST) framework to identify a streamlined behavioral sleep intervention for gynecologic cancer survivors. Three candidate intervention components previously shown to decrease sleep disturbance will be evaluated, including sleep restriction, stimulus control, and systematic bright light exposure. Participants will be adult women with a history of non-metastatic gynecologic cancer who have completed primary treatment and who report current poor sleep quality. Fifteen participants will be recruited for Part 1 of the study, which will utilize qualitative methods to identify barriers to and facilitators of intervention adherence. Results will inform changes to the delivery of the candidate intervention components to promote adherence in Part 2, where 80 participants will be recruited and randomized to one of eight conditions reflecting every possible combination of the three candidate intervention components in a full factorial design. Participants will complete assessments at baseline, post-intervention, and 3-months post-intervention. Part 2 results will identify the combination of candidate intervention components that yields the most efficacious yet efficient 6-week intervention for diminishing sleep disturbance. This is the first known study to apply the MOST framework to optimize a behavioral sleep intervention and will yield a resource-efficient treatment to diminish sleep disturbance, improve health-related quality of life, and decrease symptom burden among gynecologic cancer survivors. ClinicalTrials.gov Identifier: NCT05044975.
Mature adipocytes in bone marrow protect myeloma cells against chemotherapy through autophagy activation (2015)

A major problem in patients with multiple myeloma is chemotherapy resistance, which develops in myeloma cells upon interaction with bone marrow stromal cells. However, few studies have determined the role of bone marrow adipocytes, a major component of stromal cells in the bone marrow, in myeloma chemotherapy resistance. We reveal that mature human adipocytes activate autophagy and upregulate the expression of autophagic proteins, thereby suppressing chemotherapy-induced caspase cleavage and apoptosis in myeloma cells. We found that adipocytes secreted known and novel adipokines, such as leptin and adipsin. The addition of these adipokines enhanced the expression of autophagic proteins and reduced apoptosis in myeloma cells. In vivo studies further demonstrated the importance of bone marrow-derived adipocytes in the reduced response of myeloma cells to chemotherapy. Our findings suggest that adipocytes, adipocyte-secreted adipokines, and adipocyte-activated autophagy are novel targets for combatting chemotherapy resistance and enhancing treatment efficacy in myeloma patients.
Evidence for Immune Regulation in the Induction of Transplantation Tolerance: A Conditional but Limited Role for IL-4 (1999)

Most experimental models of allograft tolerance depend on manipulation of immune responses at the time of transplant. In such systems, the graft itself probably plays an important role in the induction of unresponsiveness but as a consequence may suffer immune mediated damage. Ideally, recipients would be made specifically unresponsive before transplant such that the graft is protected from the outset. In this report, we demonstrate that CBA mice pretreated with donor-specific transfusion plus anti-CD4 Ab 28 days before transplant accept cardiac allografts indefinitely without further intervention. Adoptive transfer of spleen cells from mice with long term surviving grafts results in donor-specific graft acceptance in naive secondary recipients, indicating that tolerance in this system involves immuneregulation. Regulation develops as a result of the pretreatment protocol alone, since transfer of cells from pretreated but untransplanted mice to naive recipients also leads to prolonged allograft survival without additional therapy. Neutralizing IL-4 at the time of tolerance induction had no effect on graft outcome in primary recipients. However, removal of IL-4 from the adoptive transfer donors at the time of tolerance induction prevented long term engraftment in the majority of secondary recipients. Our data demonstrate that pretreatment of transplant recipients can establish immune regulation powerful enough to override the responses of an intact immune repertoire and that under stringent conditions at least, development of this regulatory population may in part be dependent on IL-4.
Robust Semi-Blind Estimation for Beamforming Based MIMO Wireless Communication (2008)

In this paper, we present robust semi-blind (SB) algorithms for the estimation of beamforming vectors for multiple-input multiple-output wireless communication. The transmitted symbol block is assumed to comprise of a known sequence of training (pilot) symbols followed by information bearing blind (unknown) data symbols. Analytical expressions are derived for the robust SB estimators of the MIMO receive and transmit beamforming vectors. These robust SB estimators employ a preliminary estimate obtained from the pilot symbol sequence and leverage the second-order statistical information from the blind data symbols. We employ the theory of Lagrangian duality to derive the robust estimate of the receive beamforming vector by maximizing an inner product, while constraining the channel estimate to lie in a confidence sphere centered at the initial pilot estimate. Two different schemes are then proposed for computing the robust estimate of the MIMO transmit beamforming vector. Simulation results presented in the end illustrate the superior performance of the robust SB estimators.
Über eine Färbemethode zum Anfärben von Aminosäuren, Peptiden und Proteinen auf Papierchromatogrammen und Papierelektropherogrammen (1954)

Abstract Durch Chlorieren von Papierelektropherogrammen bzw. Papier‐chromatogrammen unter genau beschriebenen Bedingungen gelingt es, Aminosäuren, Peptide oder Proteine in die Chloraminderivate überzuführen. Diese werden dann mit o ‐Tolidin oder Benzidin in essigsaurer Lösung unter Zusatz von Kaliumjodid durch tiefblau bis blauschwarz gefärbte Verbindungen am Papier dauerhaft angefärbt. Die Empfindlichkeit der Methode beträgt 1.4 γ Amino‐Stickstoff/ccm (1/10000 m Amino‐Stickstoff).