MP57-20 VARIANT HISTOLOGY DOES NOT PREDICT SURVIVAL OUTCOMES AFTER RADICAL NEPHROURETERECTOMY FOR UPPER TRACT UROTHELIAL CARCINOMA: RESULTS FROM THE CANADIAN UPPER TRACT COLLABORATION (2015)

You have accessJournal of UrologyKidney Cancer: Surgical Therapy II1 Apr 2015MP57-20 VARIANT HISTOLOGY DOES NOT PREDICT SURVIVAL OUTCOMES AFTER RADICAL NEPHROURETERECTOMY FOR UPPER TRACT UROTHELIAL CARCINOMA: RESULTS FROM THE CANADIAN UPPER TRACT COLLABORATION Lucas Dean, Adrian Fairey, Niels Jacobsen, Simon Tanguay, Ricardo Rendon, David Bell, Jonathan Izawa, Joseph Chin, Anil Kapoor, Bobby Shayegan, Edward Matsumoto, Peter Black, Alan So, Jean-Baptiste Lattouf, Fred Saad, Darrel Drachenberg, Ilias Cagiannos, Louis Lacombe, Yves Fradet, and Wassim Kassouf Lucas DeanLucas Dean More articles by this author , Adrian FaireyAdrian Fairey More articles by this author , Niels JacobsenNiels Jacobsen More articles by this author , Simon TanguaySimon Tanguay More articles by this author , Ricardo RendonRicardo Rendon More articles by this author , David BellDavid Bell More articles by this author , Jonathan IzawaJonathan Izawa More articles by this author , Joseph ChinJoseph Chin More articles by this author , Anil KapoorAnil Kapoor More articles by this author , Bobby ShayeganBobby Shayegan More articles by this author , Edward MatsumotoEdward Matsumoto More articles by this author , Peter BlackPeter Black More articles by this author , Alan SoAlan So More articles by this author , Jean-Baptiste LattoufJean-Baptiste Lattouf More articles by this author , Fred SaadFred Saad More articles by this author , Darrel DrachenbergDarrel Drachenberg More articles by this author , Ilias CagiannosIlias Cagiannos More articles by this author , Louis LacombeLouis Lacombe More articles by this author , Yves FradetYves Fradet More articles by this author , and Wassim KassoufWassim Kassouf More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2008AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Predictors of survival after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC) include age, pathologic TNM stage, lymphovascular invasion (LVI), histologic grade, and tumor architecture. Little data are available on the role of variant histology as a prognostic factor for survival. The objective of this study was to investigate the association between variant histology and survival outcomes in patients who underwent RNU for UTUC. METHODS Institutional RNU databases containing information on UTUC patients treated between 1994 and 2009 were obtained from 10 academic centers in Canada. Data were collected on 1029 patients and combined into a relational database formatted with patient characteristics, pathologic characteristics, and survival status. Histologic type was categorized as pure urothelial carcinoma (UC; N=972) or UC + variant histology (N=40). Kaplan-Meier analysis and Cox proportional regression models were used to analyze overall survival (OS), disease-specific survival (CSS), and recurrence-free survival (RFS). RESULTS Median follow-up duration was 2.5 years (IQR: 0.6-6.2 years). Baseline characteristics were similar between groups except that the UC + variant histology group had a higher proportion of patients with concomitant carcinoma in-situ (7.5% vs. 3.6%, p=0.016) and LVI (25% vs 16%; p=0.01). Overall survival (65% vs 69%; p=0.58), DSS (77% vs 79%; p=0.84), and RFS (42% vs 47%; p=0.60) did not differ between groups. On multivariate analysis, UC + variant histology was not independently associated with OS (HR 0.89; 95% CI 0.46-1.71; p=0.74), DSS (HR 0.66; 95% CI 0.27-1.62; p=0.37), or RFS (HR 0.87; 95% CI 0.53-1.42; p=0.56). CONCLUSIONS Despite being associated with concomitant CIS and LVI, the presence of UC + variant histology was not predictive of survival outcomes following RNU for UTUC. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e697 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Lucas Dean More articles by this author Adrian Fairey More articles by this author Niels Jacobsen More articles by this author Simon Tanguay More articles by this author Ricardo Rendon More articles by this author David Bell More articles by this author Jonathan Izawa More articles by this author Joseph Chin More articles by this author Anil Kapoor More articles by this author Bobby Shayegan More articles by this author Edward Matsumoto More articles by this author Peter Black More articles by this author Alan So More articles by this author Jean-Baptiste Lattouf More articles by this author Fred Saad More articles by this author Darrel Drachenberg More articles by this author Ilias Cagiannos More articles by this author Louis Lacombe More articles by this author Yves Fradet More articles by this author Wassim Kassouf More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...