gebhart/patrepeval huggingface dataset:
Smoke pollution and the effects of root‐knot nematodes on the growth of eggplants (1994)

Single and combined effects of smoke pollution and the root‐knot nematode, Meloidogyne incognita race 1, were studied on eggplant in 1988 and 1989 at two sites (K1 and K2) 1 and 2 km respectively away from a coal‐fired thermal power plant, and a control site at the Department of Botany, Aligarh Muslim University (AMU). Mean concentrations of SO 2 , NO 2 and suspended particulate matter (SPM) were respectively 172, 95 and 626 μg/m 3 in 1988 and 144, 97 and 556 μg/m 3 in 1989 at K1; and 258, 150 and 344 μg/m 3 in 1988 and 226, 113 and 293 μg/m 3 in 1989 at K2. Peak levels of the gases and SPM were recorded in the early (12.00–15.00) and late (15.00–18.00) afternoon respectively. Concentrations of the pollutants at a control site were very low. Marginal browning appeared on the leaves of eggplants grown at site K2 whether or not they were infected by the nematodes. The galling caused by nematodes was severe at both polluted sites but egg mass production was inhibited at K2. Egg laying was significantly reduced at both polluted sites. M. incognita significantly reduced plant growth, yield and leaf pigment production of eggplant at the control and polluted sites. Most non‐infected plants also showed significant reductions in these plant varieties i.e. from the effects of pollution at K2. Foliar concentrations of sulphur were significantly increased at both polluted sites, being greater in infected plants. The interaction of smoke pollution and M. incognita infection led to greater suppressions at the polluted sites, which were mostly significant at K1. At the polluted sites, leaves had more and longer trichomes; also the number and size of stomata were decreased but their openings were wider especially in infected plants at the two polluted sites.
Photopic ERG Negative Response from Amacrine Cell Signaling in RCS Rat Retinal Degeneration (2008)

The photopic ERG of the dystrophic RCS rat retina becomes increasingly electronegative because of an aberrant negative response, originating from amacrine cell activity, which declines more slowly than the b-wave with degeneration. The absence of this response in the P23H rat indicates that the inner retinal cone pathway pathology is different in the two models. A relative increase in Kir4.1 channels on Müller cells of RCS retina may contribute to the enhanced negative ERG response in the RCS rat.
Murine model of Kawasaki disease induced by mannoprotein-beta-glucan complex, CAWS, obtained from Candida albicans. (2004)

Intraperitoneal administration of CAWS (water-soluble extracellular polysaccharide fraction obtained from the culture supernatant of Candida albicans) to mice induces coronary arteritis similar to Kawasaki disease. We analyzed differences in the production of cytokines involved in the occurrence of coronary arteritis among mouse strains, C3H/HeN, C57BL/6, DBA/2 and CBA/J. The incidence of arteritis was 100% in C57BL/6, C3H/HeN and DBA/2 mice, but only 10% in CBA/J mice. The coronary arteritis observed in DBA/2 mice was the most serious, with several mice expiring during the observation period. The CAWS-sensitive strains revealed increased levels of IL-6 and IFN-gamma during the course of a specific response to CAWS by spleen cells. In contrast, IL-10 levels were observed to increase markedly in CAWS-resistant CBA/J mice, but not the CAWS-sensitive strains. However, TNF-alpha levels were more elevated only in DBA/2 mice. The difference in disease development and cytokine production strongly suggests that the genetic background of the immune response to CAWS contributes to the occurrence of coronary arteritis.
PTPRZ1 regulates calmodulin phosphorylation and tumor progression in small-cell lung carcinoma (2012)

PTPRZ1 was highly expressed in human NET tissues and PTPRZ1 is an oncogenic tyrosine phosphatase in SCLCs. These results imply that a new signaling pathway involving PTPRZ1 could be a feasible target for treatment of NETs.
Direct assessment of the antioxidant property of salivary histatin (2019)

Histatin, a salivary protein, affects oral homeostasis through preservation of tooth integrity and protection against caries and fungal infections. However, the effects of histatin in the generation of oxidative stress induced by reactive oxygen species and in the oral cavity remain unclear. In this study, the effects of histatin on direct reactive oxygen species scavenging activity were examined using electron spin resonance. We demonstrated, for the first time, that histatin exhibits antioxidant activity against hydroxyl radicals generated by Fenton's reaction by metal chelation or binding. The direct antioxidant effects of histatin, along with its antimicrobial activity, may be important in the oral protection of salivary proteins.
Phase transitions in the diffusion of light (2017)

We demonstrate a new phenomenon occurs in the propagation of light through random media. Due to different mechanisms of interaction, recurrent scattering of on-shell propagating fields is impeded by strongly localized evanescent couplings.
Transduction optimization of AAV vectors for human gene therapy of glaucoma and their reversed cell entry characteristics (2019)

The trabecular meshwork (TM) of the eye is responsible for maintaining physiological intraocular pressure (IOP). Dysfunction of this tissue results in elevated IOP, subsequent optic nerve damage and glaucoma, the world's leading cause of irreversible blindness. IOP regulation by delivering candidate TM genes would offer an enormous clinical advantage to the current daily-drops/surgery treatment. Initially, we showed that a double-stranded AAV2 (scAAV2) transduced the human TM very efficiently, while its single-stranded form (ssAAV2) did not. Here, we quantified transduction and entry of single- and double-strand serotypes 1, 2.5, 5, 6, 8, and 9 in primary, single individual-derived human TM cells (HTM). scAAV2 exhibited highest transduction in all individuals, distantly followed by scAAV2.5, scAAV6, and scAAV5. Transduction of scAAV1, scAAV8, and scAAV9 was negligible. None of the ssAAV serotypes transduced, but their cell entries were significantly higher than those of their corresponding scAAV. Tyrosine scAAV2 capsid mutants increased transduction in HTM cultured cells and all TM-outflow layers of perfused postmortem human eyes. These studies provide the first serotype optimization for gene therapy of glaucoma in humans. They further reveal biological differences between the AAV forms in HTM cells, whose understanding could contribute to the development of gene therapy of glaucoma.
Survival with surgical versus medical treatment of patients with bowel obstruction secondary to ovarian cancer recurrence: A 15-year experience (2009)

e16515 Background: To compare the impact of surgical versus medical management on the survival of patients presenting with small bowel obstruction (SBO) secondary to recurrent ovarian cancer. Methods: The Institutional Review Board approved a retrospective chart review of all patients with SBO due to recurrent ovarian cancer at the University of Wisconsin Hospital between January 1, 1992, and December 31, 2007. The data abstracted from patient charts included demographics, primary cancer characteristics, detailed clinical information at the time of SBO, management strategy, and outcome. Univariate analysis was performed with Cox proportional hazard model and Kaplan-Meier curves were generated for survival. Results: 71 patients met our search criteria, 6 were excluded because of a paucity of medical information. Of the 65 patients in our study, the median age was 53 years. 86% of the patients had stage III/IV ovarian cancer, while 14% had stage I/II. The median time from tumor recurrence to bowel obstruction was 17 months. 41% of patients presented with high grade bowel obstruction while 69% were low grade. 36 (55%) of patients underwent surgery for management of bowel obstruction and the remaining 29 (45%) were managed conservatively with various medical approaches. Two-year survival for the surgically managed patients was 38% compared to 18% for those who received medical treatment (p = 0.07). There was no difference in survival for patients based on histology (p = 0.38), grade (p = 0.077), grade of SBO (p = 0.56). Patients with stage I/II had a median survival of 50 months versus stage III/IV at 3.5 months (p = 0.01). Median survival for patients without ascites at time of SBO was 9.5 months while those with ascites was 3 months (p = 0.0004). Patients without abdominal or pelvic mass on CT had a median survival of 60 months; patients with any mass noted had a median survival of 3.6 months; patients with liver and lung metastases was 3 months (p = 0.001). Conclusions: In patients with bowel obstruction due to ovarian cancer recurrence; early stage at diagnosis, the absence of ascites, and lack of abdominal/pelvic mass or distant metastases significantly lengthens survival. There is a trend towards the superiority of surgical management in these patients. No significant financial relationships to disclose.
Figure S5 from Neuregulin 1 Allosterically Enhances the Antitumor Effects of the Noncompeting Anti-HER3 Antibody 9F7-F11 by Increasing Its Binding to HER3 (2023)

&lt;p&gt;Supplemental Fig.S5. Relative NRG1a, NRG1b and EGF mRNA expression in the cancer cell lines HCC-1806, BxPC3, A549 and HPAC. Quantification data were normalized to the amplification data for the reference gene HPRT.&lt;/p&gt;
Controlling of two destructive zooplanktonic predators in Chlorella mass culture with surfactants (2021)

A chemical method using 10 mg L<sup>-1</sup> SDBS as pesticide to control predatory flagellate or ciliate contamination in Chlorella mass culture was proposed. The method helps for a sustained microalgae biomass production and utilization, especially for biofuel production.
A Case Series Analysis on the Clinical Experience of Impella 5.5® at a Large Tertiary Care Centre (2021)

In this early experience of the pVAD 5.5, procedural and device-related complications were observed but were manageable, and overall survival was high in this critically ill cohort, particularly when the device was used as a bridge to other therapies.
Cytotoxic Effect and Fatty Acid Composition of Lipopolysaccharide from Vibrio vulnificus (1999)

감염성 Vibrio vulnificus에 의한 패혈증과 같은 질병의 원인을 알아보기 위하여 Vibrio vulnificus로 부터 세포벽 lipopolysaccharide를 추출한 후 지방산 조성을 분석하고 limulus gelation activity와 lethal toxicity를 측정하였다. 이 결과들을 비감염성 Escherichia coli LPS와 감염성 Salmonella typhimurium LPS의 것들과 비교하였다. V. vulnificus LPS의 주 지방산은 myristic acid 이었고 E. coli LPS는 lauric acid, S. typhimurium LPS는 capric acid 이었다. 세가지 LPS의 Limulus gelation activity는 같았으며(0.1ng/ml), V. vulnificus LPS의 lethal toxicity는 E. coli LPS와 S. typhimurium LPS의 것과 비슷하였다. LPS 이외에도 exotoxin과 같은 인자들도 V. vulnificus에 의한 세포 독성의 원인으로 고려해야 할 것이다 【Lipopolysaccharide(LPS) from Vibrio vulnificus was purified, the fatty acid composition was analyzed, and Limulus gelation activity and lethal toxic activity were tested in order to investigate the cause of cytotoxicity by V. vutnificus. These results were compared to those of Escherichia coli LPS and Salmonella typhimurium LPS. LPS from V. vulnificus had a different fatty acid composition from those of E coli and S. typhimurium. The major fatty arid from each LPS was lauric acid for E. coli, rapric acid for S. typhimurium, and myristic acid for V. vulnificus. The Limulus gelation activities of three LPSs were the same(0.1ng/ml) and the lethal toxicity in BALB/c mouse of V vulnificus LPS was similar to those of E. coli LPS and S. typhimurium LPS. Such factor as exotoxin need to be considered to be the cause of cytotoxicity by V. vulnificus LPS.】
Supplementary Figure 5 from Definition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation (2023)

&lt;p&gt;PDF file - 125K, Chemokine receptor expression is variably expressed on human PCa cell lines and on localized and metastatic PCa tissue&lt;/p&gt;
Mycobacterium tuberculosis Nonthaburi genotype raw reads (2016)

Nonthaburi3053, Nonthaburi5069 and Nonthaburi13838 isolate of Mycobacterium tuberculosis from TB meningitis patients
LYMPHOCYTE‐LIKE CELLS OF THE TUNICATE, PYURA STOLONIFERA: BINDING OF LECTINS, MORPHOLOGICAL AND FUNCTIONAL STUDIES (1977)

In vitro investigations were carried out to determine whether lymphocyte-like (small round) cells of the tunicate Pyura stolonifera react to allogeneic cells and mitogens in a manner comparable to that of vertebrate immunocytes. The lymphocyte-like cells possessed receptors for concanavalin A, wheat germ agglutinin and soybean lectin as shown by binding of radioiodinated lectins in scintillation counting and autoradiographic assays. This binding did not induce mitogenesis. Mixtures of cells of P. stolonifera individuals taken from the same or distinct localities did not show enhanced DNA synthesis when assayed at time intervals ranging from 3 to 10 days. The small round cells of this and other tunicates are not completely similar to vertebrate lymphocytes in morphology. Our observations support the concept that these cells are not directly homologous to immunologically competent vertebrate lymphocytes, but may serve as haemopoietic stem cells as proposed by other (Endean, 1954; Freeman, 1970).
An EM-based channel estimation algorithm for space-time and space-frequency block coded OFDM (2004)

The combination of multiple-antenna and orthogonal frequency division multiplexing (OFDM) provides reliable communications over frequency selective fading channels. We investigate this approach and focus on the application of space-time block codes (STBC) and space-frequency block codes (SFBC) in OFDM systems. We compare the performance of maximum likelihood (ML), zero forcing (ZF) and conventional detection algorithms. We show that ZF provides a good trade-off between computational complexity and performance. The problem of channel estimation in STBC-OFDM and SFBC-OFDM systems is also studied, including the derivation of the Cramer-Rao lower bound (CRLB). Since knowledge of the channel is required to coherently decode STBC-OFDM and SFBC-OFDM, we propose an iterative channel estimation algorithm based on the EM algorithm that requires very few pilot symbols. The CRLB can be achieved by the channel estimation algorithm.
The Prophylactic Effect of Dexamethasone on Postoperative Nausea and Vomiting in Women Undergoing Thyroidectomy (1999)

We compared the prophylactic administration of dexamethasone to prevent nausea and vomiting with droperidol and saline in women undergoing thyroidectomy. Both dexamethasone and droperidol significantly reduced postoperative nausea and vomiting, but droperidol produced more side effects, which suggests that dexamethasone is a useful treatment in these patients.
Engineering Phototheranostic Nanoscale Metal–Organic Frameworks for Multimodal Imaging-Guided Cancer Therapy (2016)

Many photoresponsive dyes have been utilized as imaging and photodynamic/photothermal therapy agents. Indocyanine green (ICG) is the only near-infrared region (NIR) organic dye for clinical applications approved by the United States Food and Drug Administration; however, the clinical application of ICG is limited by its poor aqueous solubility, low cancer specificity, and low sensitivity in cancer theranostics. To overcome these issues, a multifunctional nanoplatform based on hyaluronic acid (HA) and ICG-engineered metal-organic framework MIL-100(Fe) nanoparticles (MOF@HA@ICG NPs) was successfully developed for imaging-guided, anticancer photothermal therapy (PTT). The synthesized NPs showed a high loading content of ICG (40%), strong NIR absorbance, and photostability. The in vitro and in vivo imaging showed that the MOF@HA@ICG NPs exhibited greater cellular uptake in CD44-positive MCF-7 cells and enhanced tumor accumulation in xenograft tumors due to their targeting capability, compared to MOF@ICG NPs (non-HA-targeted) and free ICG. The in vitro photothermal toxicity and in vivo PTT treatments demonstrated that MOF@HA@ICG NPs could effectively inhibit the growth of MCF-7 cells/xenograft tumors. These results suggest that MOF@HA@ICG NPs could be served as a new promising theranostic nanoplatform for improved anticancer PTT through cancer-specific and image-guided drug delivery.
Noise detection during heart sound recording (2009)

Heart sound is a valuable biosignal for early detection of a large set of cardiac diseases. Ambient and physiological noise interference is one of the most usual and high probable incidents during heart sound acquisition. It may change the prominent and crucial characteristics of heart sound which may possess important information for heart disease diagnosis. In this paper, we propose a new method to detect ambient and internal body noises in heart sounds. The algorithm utilizes physiologically inspired periodicity/semi-periodicity criteria. A small segment of clean heart sound exhibiting periodicity in the time and in the frequency domain is first detected. The sound segment is used as a template to detect uncontaminated heart sounds during recording. The technique has been tested on the heart sounds contaminated with several types of noises, recorded from 68 different subjects. Average sensitivity of 95.13% and specificity of 98.65% for non-cardiac sound detection were achieved.
[Studies on flavonoids of Andrographis paniculata]. (2006)

Compound 6 is a new naturally occurring product isolated from A. paniculata, and compound 8, 11 and 12 are obtained for the first time from the Andrographis species.
Welding Metallurgy Principles (2014)

This chapter reviews the basic principles that govern microstructure evolution in welds. It focuses primarily on fusion welds and solid-state welds. Examination of a welded joint reveals distinct microstructural regions. The fusion zone is associated with melting. The heat-affected zone (HAZ), though not melted, is affected by the heat from the joining process. The fusion zone was considered to consist of two regions that include composite region and unmixed zone (UMZ). The HAZ was subdivided into two regions, the partially melted zone (PMZ) and the “true” heat-affected zone (T-HAZ). The chapter also reviews the various regions defined, and describes the mechanisms involved in their formation. It demonstrates the range of fusion zone microstructures that are observed in a number of common material systems, including steels, stainless steels, aluminum alloys, Ni-base alloys, and Ti alloys. A few examples of microstructure evolution during solid-state welding are included in the chapter.
A Case Study Contrasting German Systematic Engineering Design With Affordance Based Design (2005)

In the young field of engineering design theory, various approaches to design differ in their conceptual bases, methods, and scope. These core differences make comparing design theories difficult. One strategy to overcome these differences, long used in the social sciences to test and compare theories, is the case study. In this paper we adopt a published design project, that of a computer monitor stand, and use it as a case study to compare two design theories. The design project was originally conducted using a form of German Systematic Engineering Design (GSED). We contrast those original results with what is obtainable using Affordance Based Design (ABD). Important insights into the differences between these two design theories quickly emerge. Among the differences found are the ways in which: customer needs data is interpreted and handled, product characteristics are represented, customer needs data flows into the ideation and selection processes, and bound and target data are utilized. Perhaps the most important difference shown is at what stage, and how, the product architecture is designed. In GSED, typically the product architecture arises in a bottom-up fashion from a combination of various sub-function solution principles. However, in ABD, the product architecture is the first subject of ideation and selection, as the high-level architecture determines in a top-down fashion most of the lower-level affordances that are designed subsequently. While no two design projects, design teams, or design methods are the same, it is hoped that this particular case study elucidates some of the salient differences between an established and a nascent design theory.
Case, Constructions, FrameNet, and the Deep Lexicon (2014)

Three major contributions that Charles Fillmore made in linguistics play an important role in the enterprise of deep lexical semantics, which is the effort to link lexical meaning to underlying abstract core theories. I will discuss how case relates to lexical decompositions, how motivated constructions span the borderline between syntax and semantics, and how the frames of FrameNet provide an excellent first step in deep inference.
Spaceflight Inhibits Bone Formation Independent of Corticosteroid Status in Growing Rats (2000)

Bone formation and structure have been shown repeatedly to be altered after spaceflight. However, it is not known whether these changes are related to a stress-related altered status of the corticosteroid axis. We investigated the role of corticosteroids on spaceflight-induced effects in rat pelvis and thoracic vertebrae. Thirty-six male Sprague-Dawley rats were assigned to a flight, flight control, or vivarium group (n = 12/group). Bilateral adrenalectomy was performed in six rats per group, the additional six rats undergoing sham surgery. Adrenalectomized (ADX) rats were implanted with corticosteroid pellets. On recovery from spaceflight, thoracic vertebrae and the whole pelvis were removed and processed for biochemistry, histomorphometry, or bone cell culture studies. The 17-day spaceflight resulted in decreased bone volume (BV) in the cotyle area of pelvic bones (-12%; p < 0.05) associated with approximately 50% inhibition of bone formation in the cancellous area of pelvic metaphyses and in thoracic vertebral bodies. The latter effect was associated with a decreased number of endosteal bone cells isolated from the bone surface (BS) in these samples (-42%; p < 0.05). This also was associated with a decreased number of alkaline phosphatase positive (ALP+) endosteal bone cells at 2 days and 4 days of culture, indicating decreased osteoblast precursor cell recruitment. Maintaining basal serum corticosterone levels in flight-ADX rats did not counteract the impaired bone formation in vertebral or pelvic bones. Moreover, the decreased ex vivo number of total and ALP+ endosteal bone cells induced by spaceflight occurred independent of endogenous corticosteroid hormone levels. These results indicate that the microgravity-induced inhibition of bone formation and resulting decreased trabecular bone mass in specific areas of weight-bearing skeleton in growing rats occur independently of endogenous glucocorticoid secretion.
Comparison of Accelerated Testing with Modeling to Predict Lifetime of CPV Solder Layers (Presentation) (2012)

Concentrating photovoltaic (CPV) cell assemblies can fail due to thermomechanical fatigue in the die-attach layer. In this presentation, we show the latest results from our computational model of thermomechanical fatigue. The model is used to estimate the relative lifetime of cell assemblies exposed to various temperature histories consistent with service and with accelerated testing. We alsopresent early results from thermal cycling experiments designed to help validate the computational model.