gebhart/patrepeval huggingface dataset:
Loss of beta1 integrin function results in upregulation of connexin expression in embryonic stem cell-derived cardiomyocytes (2005)

We show that loss of beta1 integrin function affects connexin (Cx) expression in embryonic stem (ES) cell-derived cardiomyocytes. Both loss of beta1 integrin function and inhibition of integrin clustering by RGD peptides in wild type ES cells correlated with upregulated expression of gap junctional proteins in ES-derived cardiomyocytes. The upregulation of connexin transcript levels in beta1 integrin-deficient cells is paralleled by a higher fraction of cells co-expressing Cx40 and Cx43. These observations demonstrate that the expression of connexins in developing cardiomyocytes is correlated to integrin-dependent mechanisms. Further, we found that upregulated cardiac connexin expression in beta1 integrin-deficient cells is related to Rho- and Wnt-dependent pathways. beta1 integrin-deficient cardiac cells displayed high levels of cytoplasmic gamma- and beta-catenins throughout the differentiation period. The administration of lithium, an activator of beta-catenin-dependent pathways, resulted in up-regulated connexin mRNA levels in wild type cardiomyocytes at intermediate, but not at early stages, indicating that the effects are restricted to advanced stages of cardiac differentiation. On the other hand, inhibition of Rho-dependent integrin signaling by treatment of cardiac cells with exoenzyme C3 resulted in immediate up-regulation of cardiac connexin transcript levels at early differentiation stages. Our data indicate that integrin function affects connexin expression in cardiomyocytes via direct effects on RhoA-dependent signaling mechanisms at early differentiation stages and of beta-catenin/Wnt-dependent pathways at advanced stages.
The association of cryoglobulinaemia with nodules, vasculitis and fibrosing alveolitis in rheumatoid arthritis and their relationship to serum C1q binding activity and rheumatoid factor. (1979)

Two measurements of serum immune complexes, cryoglobulinaemia and 125I-C1q binding, have been performed in patients with severe rheumatoid arthritis (RA) and compared with normal levels. Cryoglobulinaemia was present in 20 out of 28 patients (71%) with extra-articular disease (mean level 17 micrograms/ml) including nodules, digital vasculitis, cutaneous ulcers, rash, neuropathy, lung disease and scleritis, but in none of 32 patients with joint disease alone (uncomplicated RA) (mean level 3 micrograms/ml). Cryoglobulinaemia correlates with, but probably does not antedate, extra-articular disease, and may be useful in predicting morbidity and mortailty in this group of patients. In contrast, serum 125I-Clq binding was raised in patients with uncomplicated RA and those with extra-articular disease, although levels were higher in the latter group. Both tests showed a negative correlation with serum haemolytic complement and a positive correlation with IgM rheumatoid factor although there were some sera with raised levels of rheumatoid factor without cryoglobulinaemia. These results suggest that cryoglobulinaemia is a better test than Clq-binding for demonstrating the presence of circulating immune complexes involved in the pathogenesis of extra-articular lesions.
RMP (rights management and protection) system for digital broadcasting based on home servers (2003)

This paper presents an RMP (rights management and protection) system for digital broadcasting based on home servers using receivers with home storage devices. This RMP system is suitable for broadcasting, enabling rights protection and advanced access control (term of validity, usage and charge condition, etc.) of stored content on home storage devices.
Assessment of Atmospheric Limitations on the Determination of the Solar Spectral Constant from Ground-Based Spectroradiometer Measurements (1986)

Ground-based solar radiometer measurements have long been used to investigate various properties of both the Earth's atmosphere and the sun. This paper addresses the problem of attempting to measure the solar spectral irradiance with heretofore unachieved levels of accuracy and precision (~0.5 and ~0.1 percent, respectively) via spectroradiometer measurements made at high-altitude ground stations. Instrumentation and calibration approaches are discussed, but attention is primarily directed toward assessing limitations imposed by the atmosphere. Assessments of factors such as diffuse light contributions, uncertainty in airmass determination, variability in atmospheric optical depth, spectroradiometer bandwidth, and data analysis methods are included in the paper.
Tumor necrosis factor-alpha down-regulates human elastin gene expression. Evidence for the role of AP-1 in the suppression of promoter activity. (1992)

Cytokine modulation of elastin gene expression was examined by assay of elastin mRNA abundance and by transient transfections of cultured human skin fibroblasts and rat aortic smooth muscle cells with elastin promoter/reporter gene (chloramphenicol acetyltransferase, CAT) constructs. Incubation of cells with human recombinant tumor necrosis factor-alpha (TNF-alpha) markedly suppressed the elastin mRNA levels in a time- and dose-dependent manner by up to 91%. TNF-alpha also suppressed the expression of the elastin promoter/CAT construct by up to 70% in transiently transfected cells, indicating regulation at the transcriptional level. This suppression was temporally preceded by rapid and transient up-regulation of c-jun and c-fos genes. The down-regulatory effect of TNF-alpha on elastin promoter activity was abolished by co-transfections with a synthetic double-stranded AP-1 oligomer. Furthermore, co-transfection of the elastin promoter construct with c-jun and c-fos expression plasmids resulted in a marked decrease in the promoter activity. Elucidation of the cis-regulatory elements in the elastin promoter by 5' deletion construct analysis implicated a region -290 to -198 containing one AP-1 binding site. The functional role of this AP-1 site was further tested by gel retardation assays which indicated formation of a DNA-protein complex specific for TNF-alpha treated cells. This complex could be partially dissociated by a competing oligomer containing the consensus AP-1 binding site. These observations suggest that the inhibitory effects of TNF-alpha on elastin gene expression involve the transcription factor AP-1. Interferon-gamma also suppressed the elastin gene expression at the mRNA level by approximately 52%, but it had no effect on the elastin promoter activity, suggesting post-transcriptional mechanisms. These results indicate that mediators released from inflammatory cells can modulate elastin gene expression, and such modulation may play a role in diseases characterized by altered accumulation of elastic fibers in tissues.
Pyrenyl-Functionalized Fluorene and Carbazole Derivatives as Blue Light Emitters (2012)

New pyrenyl mono- and disubstituted fluorene and carbazole derivatives were synthesized and investigated as blue-emitting materials. Most of the synthesized compounds were capable of forming glasses with glass transition temperatures up to 105 °C. The mono- and disubstituted compounds exhibited efficient emission in a diluted form with the peak wavelengths of 416 and 422 nm and quantum yields of 0.72 and 0.82, respectively. Photophysical properties of the compounds in dilute solutions and solid state were investigated experimentally and rationalized by density functional theory calculations. The calculations revealed a low energy barrier for intramolecular twisting in the ground and excited states. The electronic spectra of the compounds were dominated by an allowed "pyrene-like" S0 → S2 transition prevailing in nearly perpendicularly twisted molecular structures and competitive S0 → S1 transition becoming increasingly allowed for more planar conformers. The disubstituted compounds demonstrated a 3-fold enhanced oscillator strength of S0 → S1 transition, giving rise to the enhanced fluorescence quantum yield, significant shortening of the fluorescence lifetimes (from 2.5 ns down to 1.0 ns), and 3-fold reduced amplified spontaneous emission threshold as compared with those of the monosubstituted compounds. Introduction of the bulky dihexyl group into the pyrenyl-disubstituted fluorene enabled remarkable suppression of emission concentration quenching in a solid state and ensured high emission quantum yield (0.63) in the wet-casted neat films. Pyrenyl disubstitution of fluorene and a sterically hindered aliphatic group enabled observation of a low amplified spontaneous emission threshold (20 kW/cm2) for the compound dispersed in the inert polystyrene host at a rather large (5 wt %) chromophore concentration.
Supplementary Data 7 from Inhibition of NF-κB–Dependent Signaling Enhances Sensitivity and Overcomes Resistance to BET Inhibition in Uveal Melanoma (2023)

&lt;p&gt;The combination PLX51107+PTL induces apoptosis in the BETi-resistant cells. p-p65 expression does not change in liver biopsies of UM patients treated with PLX51107&lt;/p&gt;
High-performance variable-length packet scheduling algorithm for IP traffic (2002)

A high-performance variable-length packet scheduling algorithm is proposed for efficiently accommodating IP traffic in input. queued crossbar switches. It uses a rotating priority(round-robin) arbitration and a masking operation for variable-length packets. This algorithm achieves 100% throughput with a single iteration for uniform IP traffic and performs better in terms of packet latency and similar cell latency, compared with the well-known iSLIP cell-level scheduling algorithm.
Detection of secondary amines on solid phase. (1996)

The detection of secondary amino groups in building blocks attached to solid phase using tetrachlorobenzoquinone (chloranil) was re-examined. A new procedure, about ten times more sensitive than the original method, has been developed. Except for N(p-tolyl)glycine, all secondary amino groups that were examined were detected reliably in a substitution range down to 2.8 micro eq/g. Protected imidazole in His(Trt) did not interfere with the detection method.
Growth Hormone (GH) Pharmacogenetics: Influence of GH Receptor Exon 3 Retention or Deletion on First-Year Growth Response and Final Height in Patients with Severe GH Deficiency (2006)

Patients with GHD who are homozygous for GHR exon 3 fl were less responsive to short- and long-term hGH therapy. Approximately half of the population is homozygous for GHRfl, and future studies adjusting hGH therapy to genotype may improve outcome.
Silver Nanoparticle/Boron-Doped Graphene Nanoribbon Nanocomposite for Effective Surface Enhanced Raman Scattering (2017)

Surface-enhanced Raman scattering (SERS) provides high sensitivity and selectivity on molecule detection, making it attractive for biomedical and chemical detections. Generally there are two mechanisms to influence the SERS enhancement: electromagnetic mechanism (EM) created by the metals with surface plasmon resonance (SPR) property and chemical mechanism (CM) due to the charge transfer between the molecule and the substrate. The development of synthetic method to produce nanostructures with controllable EM and CM properties will lead to important advances on both fundamental study and innovative applications for SERS-based biomedical detections. Graphene nanoribbons (GNRs) represent a unique structure of carbon nanomaterials with controlled electronic properties by tuning their widths, making them can be potentially useful as the SERS-active substrate and used in other applications including energy, composites, biomedical and electronics. Here we report a rational design to develop a SERS-active nanocomposite with improved EM and CM properties. Toward this goal, we prepared silver (Ag)/Boron-doped GNR (B-GNR) composites using a sequential reaction route. First we synthesized GNRs with averaged width around 4 to 5 nm by the chemical unzipping of singled-walled carbon nanotubes (SWCNTs). Additionally, the prepared GNRs were doped with B atoms by a controlled carbonthemic reaction under argon (Ar) flow at atmospheric pressure and the B dopant concentration was about 1.4 atomic percentage (atom%) according to the X-ray photoelectron spectroscopy (XPS) analysis. Ag NPs with 10 nm averaged size were decorated onto the B-GNRs surface through an atmospheric-pressure microplasma-assisted redox reaction. Detailed materials characterizations including transmission electron microscopy and UV-Vis spectroscopy show that Ag/B-GNR composites were successfully synthesized in our experiment. We further systematically studied the Raman response of the Ag/B-GNR composite using Rhodamine 6G (R6G) as the Raman probe molecules. The result indicates that the Ag/GNR composite shows superior SERS performance with low detection concentration of 10 -12 M of R6G and high enhance factor (EF) of 1.9x10 12 . We furthermore systematically studied the CM enhancement via different probing molecules and substrates. Results show that SERS performance is strongly influenced by the charge transfer mechanism induced by the energy gap between the substrate Fermi level and the LUMO energy of probing molecules. Our study provide the conception to design the applicable SERS substrates. Figure 1
Elloramycins B, C, D, E and F: Minor congeners of the elloramycin producer Streptomyces olivaceus. (1986)

Elloramycin (1) is a new anthracycline-like antibiotic with a permethylated L-rhamnose in a phenolic a-glycosidic linkage2,3). Structureactivity considerations4,5) resulted in the hypothesis that less lipophilic, i.e. less methylated elloramycin derivatives will result in better solubility, which is necessary for uptake by living cells. Furthermore, additional polar groups would perhaps increase the interaction with DNA resulting in enhanced antitumor activity. The high level of O-methylation in 1 marks an unusual biosynthetic activity of the producer strain Streptomyces olivaceus. We expected less meth-
An angle-scanned cryogenic Fabry–Pérot interferometer for far-infrared astronomy (2020)

The sensitivity of state-of-the-art superconducting far-infrared detectors used in conjunction with cryogenically cooled space telescopes and instrumentation is such that spectroscopic observations are generally limited by photon noise from the astronomical source or by galactic foreground or zodiacal emission within the field-of-view. Therefore, an instrument design that restricts the spectral bandpass viewed by the detector must be employed. One method of achieving background limited, high resolution spectroscopy is to combine a high resolution component such as a Fabry-Pérot interferometer (FPI) with a lower resolution, post-dispersing system, such as a grating spectrometer, the latter serving to restrict the spectral bandpass. The resonant wavelength of an FPI is most often tuned by changing the spacing or medium between the parallel reflecting plates of the etalon. In this paper, we present a novel design for an FPI in which the wavelength is tuned by scanning the angle of incidence on a high refractive index etalon. This concept simplifies the cryomechanical design, actuation, and metrology. The first results from the realized instrument are presented and compared with theory. The effects on the spectral response as a function of the incident angle have been simulated and shown to agree well with the observation.
A Movable Surface: Formation of Yersinia sp. Biofilms on Motile Caenorhabditis elegans (2004)

Bubonic plague is transmitted by fleas whose feeding is blocked by a mass of Yersinia pestis in the digestive tract. Y. pestis and the closely related Y. pseudotuberculosis also block the feeding of Caenorhabditis elegans by forming a biofilm on the nematode head. C. elegans mutants with severe motility defects acquire almost no biofilm, indicating that normal animals accumulate the biofilm matrix as they move through a Yersinia lawn. Using the lectin wheat germ agglutinin as a probe, we show that the matrix on C. elegans contains carbohydrate produced by Yersinia. The carbohydrate is present in bacterial lawns prior to addition of nematodes, indicating that biofilm formation does not involve signaling between the two organisms. Furthermore, biofilm accumulation depends on continuous C. elegans exposure to a lawn of Yersinia bacteria.
Performance Comparison of AR Codebook Training for Speech Processing (2020)

In this paper, different ways of training codebook containing autoregressive (AR) parameter vectors are discussed. The fundamental goal of the discussion is to investigate if the classical approach for training AR-codebooks by clustering line spectral frequencies (LSF) can be improved. To do this, we discuss and evaluate the alternatives in terms of the de-correlated AR-parameters and manifold learning. The different training methods are evaluated using different metrics quantifying the distance between actual power spectral density (PSD) and the estimated PSD from the AR-codebook. The experimental results show that the training on the de-correlated features can improve the performance to some degree compared to the traditional LSF training approach in terms of the Itakura-Saito divergence not in terms of the Kullback-Leibler divergence, the log-spectral distortion and speech distortion.
Fluosilicate Solubilities Affect HF Acid Compositions (1994)

Summary The purpose of this work was to determine the solubilities of sodium and potassium fluosilicate over a broad range of HCl concentrations, ionic strengths, and temperatures. These data were required for determining optimum or safe HCl/HF treating-fluid compositions for acidizing sandstone formations containing feldspars. Solubilities of sodium and potassium fluosilicate were determined over a temperature range of 150 to 300°F. Analysis of the solubility data indicated that the solids formed were not simply Na2SiF6 and K2SiF6. Regression analyses indicated that the sodium salt could best be described as NaHSiF6 · 0.52HCl (or Na0.48H1.52SiF60.52NaCl). Regression analyses indicated that the potassium salt could best be described as KHSiF6 · 0.41KCl (or K1.41H0.59SiF6· 0.41 HCl). The solubility data were then included in a HF-spending simulator to determine regions where possible precipitation of the fluosilicates could occur. Optimum HCl/HF concentrations were then determined for specific mineral and temperature conditions.
Microfacies of some Archean cherts (Pilbara, Australia) (2006)

International audience
Beta-adrenergic receptor blockade in angiosarcoma: Which beta-blocker to choose? (2022)

Beta-blockers are currently studied to improve therapeutic options for patients with angiosarcoma. However, most of these patients have no cardiovascular co-morbidity and it is therefore crucial to discuss the most optimal pharmacological properties of beta-blockers for this population. To maximize the possible effectiveness in angiosarcoma, the use of a non-selective beta-blocker is preferred based on <i>in vitro</i> data. To minimize the risk of cardiovascular adverse events a beta-blocker should ideally have intrinsic sympathomimetic activity or vasodilator effects, e.g. labetalol, pindolol or carvedilol. However, except for one case of carvedilol, only efficacy data of propranolol is available. In potential follow-up studies labetalol, pindolol or carvedilol can be considered to reduce the risk of cardiovascular adverse events.
Combate aos ninhos do cupim Syntermes sp. com inseticidas (1976)

O presente trabalho teve como objetivo combater o cupim semisubterrneo Syntermes sp., praga de pastagens. Foram usados 6 inseticidas: foxim, fentiom, endossulfam, protoato, aldrim e fenitrotiom. Os melhores resultados foram obtidos com o fentioni e endossulfam.&#x0D; A aplicação das caldas inseticidas teve lugar em perfurações perpendiculares superfície do solo, feitas na parte superior dos cupinzeiros. Entre a aplicação e a escavação passaram-se 10 meses.
SBus G-link transmitter and receiver modules for an event builder system (2002)

A G-Link transmitter card and a G-Link receiver card as SBus mezzanine cards were developed for an event builder system. The modules have a 32-bit/spl times/32 kbyte FIFO and can transmit/receive data at the rate of 100 Mbyte/sec. The data stream from the transmitter passes through a transparent switch network before it reaches receiver modules. Traffic control in the modules as well as in the switch network is done via an external port using Taxi chips in an external controller. The transmitters and the receivers can also be used for simple serial data links.
Targeting CUB Domain-Containing Protein 1 with a Monoclonal Antibody Inhibits Metastasis in a Prostate Cancer Model (2008)

Through a whole-cell panning approach, we previously identified a panel of antibodies that bound to prostate cancer cell surface antigens. One such antigen, CUB domain-containing protein 1 (CDCP1), was recognized by monoclonal antibody 25A11 and is a single transmembrane molecule highly expressed in several metastatic cancers as well as on CD34(+)CD133(+) myeloid leukemic blast cells. We show CDCP1 expression on prostate cancer cell lines by real-time quantitative PCR (RT-qPCR), flow cytometry, and immunohistochemistry and on prostate cancer patient samples by RT-qPCR and immunohistochemical staining. In cell-based assays, antibody 25A11 inhibited prostate cancer cell migration and invasion in vitro. Further characterization showed that CDCP1 is internalized on antibody binding. When 25A11 was coupled to the cytotoxin saporin either directly or via a secondary antibody, both resulted in prostate cancer cell killing in vitro. In vivo targeting studies with an anti-CDCP1 immunotoxin showed significant inhibition of primary tumor growth as well as metastasis in a mouse xenograft model. These data provide support for continued evaluation of anti-CDCP1 therapy for potential use in cancer in primary and metastatic disease.
ChemInform Abstract: A SIMPLE HIGH‐YIELD PREPARATION OF POTASSIUM TRIS(OXALATO)IRIDATE(III) WITH A NOVEL SOLVENT EXTRACTION STEP (1983)

Abstract Durch funftägige Reaktion von K‐hexachloroiridat und K‐oxalat in Wasser unter Rückfluß wird nach Fällung mit EtOH, Wiederauflösung der Oxalatmischung in Wasser, Zugabe von Bu 4 NH(SO 4 ) und Extraktion mit MeNOz nach Aufarbeitung der Titelkomplex mit 60‐70% Ausb. erhalten.
Towards real implementations of dynamic robust routing exploiting path diversity (2009)

In this paper we compare the performance of tree different dynamic traffic engineering algorithms exploiting path diversity in the Internet, TEXCP, TRUMP and MIRTO. We passed through a thorough implementation phase of these algorithms solving a number of issues related to protocol implementation that allows a complete analysis in real traffic settings in real networks. We discuss the performance of such protocols and some difficulties encountered during their implementation. Supported by an already mature standardization framework we conclude that dynamic yet stable traffic engineering is not only feasible but expected with rising interest by network operators.
The PXIE LEBT Design Choices (2017)

Typical front-ends of modern light-ion high-intensity accelerators typically consist of an ion source, a Low Energy Beam Transport (LEBT), a Radiofrequency Quadrupole (RFQ) and a Medium Energy Beam Transport (MEBT), which is followed by the main linac accelerating structures. Over the years, many LEBTs have been designed, constructed and operated very successfully. In this paper, we present the guiding principles and compromises that lead to the design choices of the PXIE LEBT, including the rationale for a beam line that allows un-neutralized transport over a significant portion of the LEBT whether the beam is pulsed or DC.