gebhart/patrepeval huggingface dataset:
Advanced interconnect materials for ink-jet printing by low temperature sintering (2009)

In this study, we reported the development of a novel highly electrically conductive adhesive (ECA) that can be used in ink-jet printing and have the function of adhesive by a single step of low temperature sintering/curing. With the introduction of silver nanoparticles into the formulation, the electrical resistivity of the resulting ECAs is about 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−5</sup> ohm⋅cm after sintering at 180 °C or using a typical lead-free reflow profile (sintering/curing time: several minutes), which is compatible with industrial processis and favorable for the industrial applications. As is known, the strong adhesion of epoxy may enable the resulting ECA to be printed on various kinds of substrates, especially on flexible organic substrates, which is very promising for microelectronic applications. Moreover, the effects of time, temperature and the acid on the electrical resistivity of the ECA have been investigated, providing an in-depth understanding of the enhanced electrical properties. Finally, the contact resistance of the ECA on Cu surface can be stabilized for more than 1500 hrs. Thus the newly developed ECA can be ink-jettable, be compatible with industrial processes, has very low electrical resistivity by low temperature sintering/curing and could provide a strong adhesion to various substrates. The superior material properties of the formulated ECA combined with ink-jet printing technology will be very promising for a wide range of industrial applications in electronic industry.
In Situ Attenuated Total Reflection Infrared Spectroscopy on Electrochemical Ammonia Oxidation over Pt Electrode in Alkaline Aqueous Solutions (2015)

The electrochemical oxidation of ammonia over Pt electrode in alkaline aqueous solutions was studied by in situ attenuated total reflection infrared (ATR-IR) spectroscopy. In 0.1 M NH3-1 M KOH, the band ascribable to the HNH bending mode of adsorbed NH3 was confirmed at 1662-1674 cm(-1) in the potential range of 0.1-1.1 V. The intensity of this band decreased continuously with a rise in potential, indicating the oxidative consumption of adsorbed ammonia. In response to this behavior, the band at 1269 cm(-1) appeared alternatively above 0.2 V, and its intensity reached the local maximal value at ca. 0.4 V. Note that this potential of ca. 0.4 V agreed well with the onset potential of ammonia oxidation, ca. 0.45 V, in the linear sweep voltammogram. This 1269 cm(-1) band was assigned to the NH2 wagging mode of N2H4, which was one of the active intermediates, N2H(x+y,ad) (x = 1 or 2, y = 1 or 2), according to the mechanism proposed by Gerischer and Mauere. To the best of our knowledge, this is the first report for the detection of N2H4 as a reaction intermediate over Pt electrode. Furthermore, the formation of bridged NO was also observed above the onset potential of ammonia oxidation, ca. 0.5 V. Such adsorbed NO species probably inhibit the electrochemical reaction due to the occupation of reaction sites at higher potential.
Dinitroaniline Activity inToxoplasma gondiiExpressing Wild-Type or Mutant α-Tubulin (2010)

The human parasite Toxoplasma gondii is sensitive to dinitroaniline compounds which selectively disrupt microtubules in diverse protozoa but which have no detectable effect on vertebrate host cell microtubules or other functions. Replication of wild-type T. gondii is inhibited by 0.5 to 2.5 microM oryzalin, but mutant parasites harboring amino acid substitutions in the predicted dinitroaniline binding site confer resistance up to 40 microM oryzalin. However, the precise interaction between dinitroanilines and the binding site in alpha-tubulin remains unclear. We have investigated the activity of 12 dinitroanilines and the related compound amiprophos methyl on wild-type and dinitroaniline-resistant parasite lines that contain proposed binding site mutations. These data indicate that dinitramine is the most effective dinitroaniline to inhibit Toxoplasma growth in wild-type parasites and most resistant lines. Dinitramine has an amine group at the meta position not present in any of the other dinitroanilines tested here that is predicted to form hydrogen bonds with residues Arg2 and Gln133 according to docking data. Remarkably, although the binding site mutation Ile235Val confers increased resistance to most dinitroanilines, it confers increased sensitivity to GB-II-5, a compound optimized for activity against kinetoplastid tubulin. Kinetoplastid parasites have a valine at position 235 of alpha-tubulin, whereas apicomplexan parasites have an isoleucine at this site. We suggest that this heterogeneity in binding site environment influences relative dinitroaniline sensitivity in distinct protozoan lineages and hypothesize that a mutation that makes the apicomplexan dinitroaniline binding site more like the kinetoplastid site increases sensitivity to a dinitroaniline optimized for activity in the latter parasites.
Jitter characterization of incoherently sub-sampled high-speed digital signals (2010)

A jitter characterization approach for incoherently sub-sampled high-speed digital signals using back-end signal processing algorithms is presented. Signal sub-sampling is used to increase the effective sampling rate of the digitizer used for data acquisition while incoherent sampling is utilized to simplify the data acquisition hardware. Algorithms for signal clock recovery and waveform reconstruction from the acquired data are developed in this research. The algorithms utilize peak identification of the sampled signal spectrum and the sparsity of the reconstructed waveform in the frequency domain as decision criteria for accurate signal reconstruction. To quantize the jitter value of such a reconstructed waveform, a wavelet based denoising method is used to generate a self-reference signal against which zero-crossing times are compared to generate jitter statistics. In addition, the data dependent jitter components can be differentiated from the original jitter by analyzing zero-crossing discrepancies of the self-reference signal.
Power-sensitive multithreaded architecture (2012)

The power consumption of microprocessors is becoming increasingly important in design decisions, not only in mobile processors, but also now in high-performance processors. Power-conscious design must therefore go beyond technology and low-level design, but also change the way modern processors are architected. A multithreading processor is attractive in the context of low-power or power-constrained devices for many of the same reasons that enable its high throughput. Primarily, it supplies extra parallelism via multiple threads, allowing the processor to rely much less heavily on speculation. We show that a simultaneous multithreading processor utilizes up to 22% less energy per instruction than a single-threaded architecture. We also explore other power optimizations that are particular to multithreaded architectures, either because they are unavailable to or unreasonable for single-thread architectures.
A hierarchical monothetic document clustering algorithm for summarization and browsing search results (2004)

Organizing Web search results into a hierarchy of topics and sub-topics facilitates browsing the collection and locating results of interest. In this paper, we propose a new hierarchical monothetic clustering algorithm to build a topic hierarchy for a collection of search results retrieved in response to a query. At every level of the hierarchy, the new algorithm progressively identifies topics in a way that maximizes the coverage while maintaining distinctiveness of the topics. We refer the proposed algorithm to as DisCover. Evaluating the quality of a topic hierarchy is a non-trivial task, the ultimate test being user judgment. We use several objective measures such as coverage and reach time for an empirical comparison of the proposed algorithm with two other monothetic clustering algorithms to demonstrate its superiority. Even though our algorithm is slightly more computationally intensive than one of the algorithms, it generates better hierarchies. Our user studies also show that the proposed algorithm is superior to the other algorithms as a summarizing and browsing tool.
Effects of Chitosan Coating for Liposomes as an Oral Carrier (2011)

The chitosan-coated liposomes (chitosomes) were designed to improve the stability in the gastrointestinal (GI) tract and to enhance the efficacy for oral drug delivery of liposomes. The phosphatic acid (PA)-incorporated anionic liposomes were surface-coated with water soluble chitosan (WSC) by electro-ionic interaction. The shape of the chitosomes observed by transmission electron microscopy (TEM) was spherical in all the formulations and the coating layer by WSC could be founded through TEM images. The mean size and the zeta potential values of the chitosomes increased significantly with depending on the content of WSC added for coating the liposomes. The stability of the chitosomes in the GI tract was confirmed through the change of relative turbidity of the liposomal suspension. The plain liposomes (plasomes) suspension without adding WSC clearly showed the change of relatively turbidity in simulated gastric fluid (SGF), while the change degree of turbidity of the chitosomes in the SGF decreased as increasing of WSC content added for coating liposome. In the 5-CF release study from the plasomes and chitosomes, the plasomes released >90% of the initial 5-CF content at 4 h of release measurement. In contrast, the chitosomes released below 40% of initial content of 5-CF. In conclusion, these results indicate that the chitosomes can be used as a potential carrier for effective oral drug delivery.
Analysis of Failed Nuclear Plant Components (2019)

Abstract Argonne National Laboratory has conducted analyses of failed components from nuclear power-generating stations since 1974. The considerations involved in working with and analyzing radioactive components are reviewed here, and the decontamination of these components is discussed. Analyses of four failed components from nuclear plants are then described to illustrate the kinds of failures seen in service. The failures discussed are (1) intergranular stress-corrosion cracking of core spray injection piping in a boiling water reactor, (2) failure of canopy seal welds in adapter tube assemblies in the control rod drive head of a pressurized water reactor, (3) thermal fatigue of a recirculation pump shaft in a boiling water reactor, and (4) failure of pump seal wear rings by nickel leaching in a boiling water reactor.
Simultaneous Observations and Analysis of Severe Storms Using Polarimetric X-Band SAR and Ground-Based Weather Radar (2010)

Recent advances in synthetic aperture radar (SAR) technology have revived meteorological applications with this type of radar. SARs are designed for surface imaging, but now that several X-band multipolarization SAR satellites are in orbit, the attenuation and backscatter caused by precipitation can be better studied. The results presented here demonstrate some of the possibilities by analyzing observations from dual-polarization (HH, VV) TerraSAR-X (TSX) acquisitions over central Florida surrounding severe storms in August 2008. Simultaneous to the SAR acquisitions, WSR-88D ground weather radars in Melbourne and Tampa Bay, FL, collected reflectivity and radial velocity data; the observed strong precipitation cells from convective storms are colocated with severe attenuation in the corresponding SAR images. The observations from SAR measurements are explained quantitatively by converting ground radar reflectivity into spaceborne radar attenuation via a theoretical model. In addition, polarization analysis comparing the SAR image to two additional TSX acquisitions 11 days apart and without rain provides an indication of storm-induced propagation effects on X-band SAR. Specifically, the copolar ratio Z_dr and the copolar correlation differences exhibit behavior that is better explained by the precipitation impact versus surface changes. Multiple regions with varying ground cover, including urban, and storm characteristics are analyzed to highlight the complexity of meteorological research using SAR while revealing a potential use of the technology to investigate the storm structure.
Video-assisted retroperitoneal debridement of infected necrotizing pancreatitis - when percutaneous drainage transforms into minimally invasive surgical procedure (2016)

Poster: ECR 2016 / C-0912 / Video-assisted retroperitoneal debridement of infected necrotizing pancreatitis - when percutaneous drainage transforms into minimally invasive surgical procedure by: Radosevic1, J. Sanchez Parrilla1, L. F. Bazan2, M. Busto3, A. Sierra Vinuesa1, F. Burdio1, J. I. Poves1, G. Aguilar Sanchez1, J. M. Maiques1; 1Barcelona/ES, 2Barcelona, Cataluna/ES, 3Barcelona, sp/ES
Clustered blockwise PCA for representing visual data (2005)

Principal Component Analysis (PCA) is extensively used in computer vision and image processing. Since it provides the optimal linear subspace in a least-square sense, it has been used for dimensionality reduction and subspace analysis in various domains. However, its scalability is very limited because of its inherent computational complexity. We introduce a new framework for applying PCA to visual data which takes advantage of the spatio-temporal correlation and localized frequency variations that are typically found in such data. Instead of applying PCA to the whole volume of data (complete set of images), we partition the volume into a set of blocks and apply PCA to each block. Then, we group the subspaces corresponding to the blocks and merge them together. As a result, we not only achieve greater efficiency in the resulting representation of the visual data, but also successfully scale PCA to handle large data sets. We present a thorough analysis of the computational complexity and storage benefits of our approach. We apply our algorithm to several types of videos. We show that, in addition to its storage and speed benefits, the algorithm results in a useful representation of the visual data.
МОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ ЛЕКАРСТВЕННОЙ ТОЛЕРАНТНОСТИ MYCOBACTERIUM TUBERCULOSIS, "Молекулярная биология" (2018)

A dramatic increase in drug-resistant forms of tuberculosis (TB) stimulates a search for novel anti-TB drugs and studies of the drug resistance acquisition. One of the possible causes is a phenotypic resistance or drug tolerance which is not associated with genomic changes. The majority of anti-TB drugs eliminate 99% of MTB cells in 3-5 days, but the remaining subpopulation becomes unsusceptible to treatment and capable for long-term persistence with ability to resuscitate once the external adverse factor is removed. This evasion of the stress factor facilitates selection of resistant forms, thus warranting long-term treatment with at least four antibacterial drugs in TB. The review considers the main mechanisms of bacterial tolerance that are due to alterations in the cell wall, activation of efflux pumps, induction of transcriptional regulons, changes in metabolic flows, and modification of molecular machineries.
Comparison of Clinical Features and Outcomes in Critically Ill Patients Hospitalized with COVID-19 versus Influenza (2020)

<b>Rationale:</b> No direct comparisons of clinical features, laboratory values, and outcomes between critically ill patients with coronavirus disease (COVID-19) and patients with influenza in the United States have been reported.<b>Objectives:</b> To evaluate the risk of mortality comparing critically ill patients with COVID-19 with patients with seasonal influenza.<b>Methods:</b> We retrospectively identified patients admitted to the intensive care units (ICUs) at two academic medical centers with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or influenza A or B infections between January 1, 2019, and April 15, 2020. The clinical data were obtained by medical record review. All patients except one had follow-up to hospital discharge or death. We used relative risk regression adjusting for age, sex, number of comorbidities, and maximum sequential organ failure scores on Day 1 in the ICU to determine the risk of hospital mortality and organ dysfunction in patients with COVID-19 compared with patients with influenza.<b>Results:</b> We identified 65 critically ill patients with COVID-19 and 74 patients with influenza. The mean (±standard deviation) age in each group was 60.4 ± 15.7 and 56.8 ± 17.6 years, respectively. Patients with COVID-19 were more likely to be male, have a higher body mass index, and have higher rates of chronic kidney disease and diabetes. Of the patients with COVID-19, 37% identified as Hispanic, whereas 10% of the patients with influenza identified as Hispanic. A similar proportion of patients had fevers (∼40%) and lymphopenia (∼80%) on hospital presentation. The rates of acute kidney injury and shock requiring vasopressors were similar between the groups. Although the need for invasive mechanical ventilation was also similar in both groups, patients with COVID-19 had slower improvements in oxygenation, longer durations of mechanical ventilation, and lower rates of extubation than patients with influenza. The hospital mortality was 40% in patients with COVID-19 and 19% in patients with influenza (adjusted relative risk, 2.13; 95% confidence interval, 1.24-3.63; <i>P</i> = 0.006).<b>Conclusions:</b> The need for invasive mechanical ventilation was common in patients in the ICU for COVID-19 and influenza. Compared with those with influenza, patients in the ICU with COVID-19 had worse respiratory outcomes, including longer duration of mechanical ventilation. In addition, patients with COVID-19 were at greater risk for in-hospital mortality, independent of age, sex, comorbidities, and ICU severity of illness.
Prostaglandin F2alpha- and FAS-activating antibody-induced regression of the corpus luteum involves caspase-8 and is defective in caspase-3 deficient mice (2003)

We recently demonstrated that caspase-3 is important for apoptosis during spontaneous involution of the corpus luteum (CL). These studies tested if prostaglandin F2alpha (PGF2alpha) or FAS regulated luteal regression, utilize a caspase-3 dependent pathway to execute luteal cell apoptosis, and if the two receptors work via independent or potentially shared intracellular signaling components/pathways to activate caspase-3. Wild-type (WT) or caspase-3 deficient female mice, 25-26 days old, were given 10 IU equine chorionic gonadotropin (eCG) intraperitoneally (IP) followed by 10 IU human chorionic gonadotropin (hCG) IP 46 h later to synchronize ovulation. The animals were then injected with IgG (2 micrograms, i.v.), the FAS-activating antibody Jo2 (2 micrograms, i.v.), or PGF2alpha (10 micrograms, i.p.) at 24 or 48 h post-ovulation. Ovaries from each group were collected 8 h later for assessment of active caspase-3 enzyme and apoptosis (measured by the TUNEL assay) in the CL. Regardless of genotype or treatment, CL in ovaries collected from mice injected 24 h after ovulation showed no evidence of active caspase-3 or apoptosis. However, PGF2alpha or Jo2 at 48 h post-ovulation and collected 8 h later induced caspase-3 activation in 13.2 +/- 1.8% and 13.7 +/- 2.2 % of the cells, respectively and resulted in 16.35 +/- 0.7% (PGF2alpha) and 14.3 PlusMinus; 2.5% TUNEL-positive cells when compared to 1.48 +/- 0.8% of cells CL in IgG treated controls. In contrast, CL in ovaries collected from caspase-3 deficient mice whether treated with PGF2alpha, Jo2, or control IgG at 48 h post-ovulation showed little evidence of active caspase-3 or apoptosis. CL of WT mice treated with Jo2 at 48 h post-ovulation had an 8-fold increase in the activity of caspase-8, an activator of caspase-3 that is coupled to the FAS death receptor. Somewhat unexpectedly, however, treatment of WT mice with PGF2alpha at 48 h post-ovulation resulted in a 22-fold increase in caspase-8 activity in the CL, despite the fact that the receptor for PGF2alpha has not been shown to be directly coupled to caspase-8 recruitment and activation. We hypothesize that PGF2alpha initiates luteolysis in vivo, at least in part, by increasing the bioactivity or bioavailability of cytokines, such as FasL and that multiple endocrine factors work in concert to activate caspase-3-driven apoptosis during luteolysis.
Retinal Gene Therapy: Surgical Vector Delivery in the Translation to Clinical Trials (2017)

An exceptionally high number of monogenic disorders lead to incurable blindness, making them targets for the development of gene-therapy. In order to successfully apply therapeutic vector systems <i>in vivo</i>, the heterogeneity of the disease phenotype needs to be considered. This necessitates tailored approaches such as subretinal or intravitreal injections with the aim to maximize transduction of target cell populations, while minimizing off-target effects and surgical complications. Strategic decisions on parameters of the application are crucial to obtain the best treatment outcomes and patient safety. While most of the current retinal gene therapy trials utilize a subretinal approach, a deeper understanding of the numerous factors and considerations in choosing one delivery approach over the other for various ocular pathologies could lead to an improved safety and treatment efficacy. In this review we survey different vector injection techniques and parameters applied in recent retinal (pre-)clinical trials. We explore the advantages and shortcomings of each delivery strategy in the setting of different underlying ocular pathologies and other relevant factors. We highlight the potential benefits for patient safety and efficacy in applying those considerations in the decision making process.
Observations of lightning flash development associated with gigantic jets (2011)

We report the observations of two gigantic jets, one during daytime over sea and one at nighttime over land, in the context of detailed associated observations of lightning flash and discharge evolution provided by a variety of radio measurements.
transientlunatic/asimov: v0.3.2 (2021)

Automation toolkit for gravitational wave analyses
Single Ended Primary Inductor Converter reliance of efficiency on switching frequency for use in MPPT application (2013)

This paper discusses the dependence of efficiency on the switching frequency of a Single Ended Primary Inductor Converter (SEPIC), for use in photovoltaic (PV) maximum power point tracking (MPPT) applications. An MPPT system comprises of a DC/DC converter and tracking algorithm set to run the PV at its maximum power point. The SEPIC is a non-inverting DC/DC converter able to output a voltage greater or less than the input voltage. In this paper we analyse the theoretical losses of the SEPIC and compare them with the practical losses measured at various switching frequency. The results show that the switching frequency of the device determines its physical size, cost and efficiency. The frequencies tested in this paper were 50Khz, 200kHz and 400kHz, with a 7% drop in efficiency between each frequency. As the switching frequency increases, the units become physically smaller and so cheaper. This however is at the cost of efficiency.
A NOVEL THREE-PHASE THREE-SWITCH THREE-LEVEL UNITY POWER FACTOR BOOST-TYPE PWM RECTIFIER (1995)

Based on the combination of a three-phase diode bridge and a DC/DC boost converter a new three-phase three-switch three-level PWM rectifier system is developed. It can be characterized by sinusoidal mains current consumption, controlled output voltage and low blocking voltage stress on the power transistors. The application could be, e.g., for feeding the DC link of a telecommunications power supply module. The stationary operational behavior, the control of the mains currents and of the output voltage are analyzed. Finally, the stresses on the system components are determined by digital simulation and compared to the stresses in a conventional PWM rectifier system.