gebhart/patrepeval huggingface dataset:
Convex Combination of Adaptive Filters with Different Tracking Capabilities (2007)

Recently, an adaptive convex combination of two LMS (least mean-square) filters was proposed and its tracking performance analyzed. Motivated by the performance of such scheme and by the differences between the tracking capabilities of the RLS (recursive least-squares) and LMS algorithms, we propose a convex combination of one LMS and one RLS filter. The resulting combination should profit of the best tracking behavior of each component filter. A steady-state analysis via energy conservation relation is also presented for stationary and non-stationary environments.
Triple hopper powder feeder system for variable composition laser cladding (1993)

In this work, a computer controlled triple hopper powder feeder system has been developed to feed and mix different elemental powders and incorporate them into the meltpool produced by a CO2 laser in such a way that the composition of the resulting clad layer can be accurately controlled and varied. Using this technique cladding a metallic surface by blowing powder into a laser generated melt pool has been successfully used to enhance the corrosion and mechanical properties of some materials. The cladding system enables variable composition clad tracks to be produced covering a substantial fraction of the possible compositions within the Al-Co-Fe ternary alloy system. The development of an automatic calibration system for determining the required powder flow rates is discussed. Analysis of the Al-Co-Fe system has demonstrated the potential of this new technique for characterising the corrosion and hardness properties of a complete ternary system. The results are presented in the form of ternary alloy maps for corrosion properties and hardness.
Fiber spin-profile designs for producing fibers with low polarization mode dispersion (1998)

Using coupled-mode theory, we develop a theoretical model to analyze the effects of fiber spin profiles on polarization mode dispersion (PMD). Constant, sinusoidal, and frequency-modulated spin profiles are examined, and phase-matching conditions are analyzed. Our analysis shows that PMD can be reduced effectively by use of frequency-modulated spin profiles.
ChemInform Abstract: NHC‐Catalyzed Oxidative Cyclization Reaction for the Synthesis of 3‐Substituted Phthalides (2014)

Abstract 33 examples
Anti-counterfeit Activities of Pharmaceutical Companies in Japan: For Patient Safety (2014)

Global spread of counterfeit medicines is an imminent threat for the patients' safety. Although major targets of counterfeits are still erectile dysfunction (ED) drugs in the industrialized countries, including Japan, anti-cancer agents and some medicines for metabolic syndromes are also being counterfeited and circulated to the market mainly through the Internet. Due to the global expansion of the business, pharmaceutical companies based in Japan are suffering from the damage of counterfeits, illegal sales including diversion, and thefts, which have never been experienced in the conventional domestic market. We, pharmaceutical companies, must be responsible for the prevention of the prevalence because our mission is to deliver effective and safe medicine to patients. For this end, we are taking necessary actions including, 1. Forestalling counterfeit, falsification and illicit trade: Measures to prevent counterfeiting are taken by introducing anti-counterfeit technologies to the packaging and tablets on a risk basis. It is also important to establish supply chain security on a global scale. 2. Finding out counterfeits and cooperating crackdown: We are conducting market and internet surveillances when high risk products are sold in high risk markets. The outcome of the criminal investigation is reported to authorities and police if necessary. 3. Conducting educational campaign to medical staff or patients: For example, four companies which manufacture and sell ED drug in Japan are collaboratively continuing activities to raise the awareness of the danger of Internet purchase. To deliver effective and safe medicines stably and globally, pharmaceutical companies extend comprehensive measures against counterfeit and illicit trading.
Coordinate Descent with Bandit Sampling (2017)

Coordinate descent methods usually minimize a cost function by updating a random decision variable (corresponding to one coordinate) at a time. Ideally, we would update the decision variable that yields the largest decrease in the cost function. However, finding this coordinate would require checking all of them, which would effectively negate the improvement in computational tractability that coordinate descent is intended to afford. To address this, we propose a new adaptive method for selecting a coordinate. First, we find a lower bound on the amount the cost function decreases when a coordinate is updated. We then use a multi-armed bandit algorithm to learn which coordinates result in the largest lower bound by interleaving this learning with conventional coordinate descent updates except that the coordinate is selected proportionately to the expected decrease. We show that our approach improves the convergence of coordinate descent methods both theoretically and experimentally.
Mechanism of Allosteric Regulation of Dnmt1's Processivity (2005)

We have analyzed the relationship between the allosteric regulation and processive catalysis of DNA methyltransferase 1 (Dnmt1). Processivity is described quantitatively in terms of turnover rate, DNA dissociation rate, and processivity probability. Our results provide further evidence that the active site and the allosteric sites on Dnmt1 can bind DNA independently. Dnmt1's processive catalysis on unmethylated DNA is partially inhibited when the allosteric site binds unmethylated DNA and fully inhibited when the allosteric site binds a single-stranded oligonucleotide inhibitor. The partial inhibition by unmethylated DNA is caused by a decrease in the turnover rate and an increase in the substrate DNA dissociation rate. Processive catalysis with premethylated DNA is not affected if the allosteric site is exposed to premethylated DNA but is fully inhibited if the allosteric site binds unmethylated DNA or poly(dA-dT). In sum, the occupancy of the allosteric site modulates the enzyme's commitment to catalysis, which reflects the nature of the substrate and the DNA bound at the allosteric site. Our in vitro results are consistent with the possibility that the processive action of Dnmt1 may be regulated in vivo by specific regulatory nucleic acids such as DNA, RNA, or poly(ADP-ribose).
Thetsrgene-coding plasmid pIJ702 prevents thiopeptin from inhibiting ppGpp synthesis inStreptomyces lividans (1989)

Streptomyces lividans normally accumulated high levels of ppGpp during nutritional shift-down. Its accumulation was, however, severely inhibited when a small amount of thiopeptin (an analogue of thiostrepton) was included in the transfer medium. In contrast, a S. lividans strain, which harbours the plasmid pIJ702 carrying the tsr gene resist to thiopeptin through methylation of the 23S rRNA, was still capable of accumulating ppGpp in the presence of large amounts of thiopeptin. These results indicate that the rRNA methylation resulting from the action of tsr gene prevents thiopeptin not only from inhibiting cell-growth but also from inhibiting ppGpp synthesis. The results also indicate that the observed accumulation of ppGpp during nutritional shift-down was associated with ribosomal function, as has been shown in E. coli and B. subtilis.
Cyclic sulfimides and sulfoximides (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclic sulfimides and sulfoximidesJoseph B. Lambert, Craig E. Mixan, and David S. BaileyCite this: J. Am. Chem. Soc. 1972, 94, 1, 208–214Publication Date (Print):January 1, 1972Publication History Published online1 May 2002Published inissue 1 January 1972https://pubs.acs.org/doi/10.1021/ja00756a037https://doi.org/10.1021/ja00756a037research-articleACS PublicationsRequest reuse permissionsArticle Views159Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PRECONDITIONING MESENCHYMAL STEM CELLS WITH TRANSFORMING GROWTH FACTOR-ALPHA IMPROVES MESENCHYMAL STEM CELL-MEDIATED CARDIOPROTECTION (2009)

Mesenchymal stem cells (MSCs) are a promising therapy for acute organ ischemia in part due to their paracrine production of growth factors. However, transplanted cells encounter an inflammatory environment that mitigates their function and survival, and treating the cells with exogenous agents during ex vivo expansion before transplantation is one strategy for overcoming this limitation by enhancing paracrine function. We hypothesized that preconditioning bone marrow MSCs with TGF-alpha would 1) increase MSC production of the critical paracrine factor, vascular endothelial growth factor (VEGF), via a p38 mitogen-activated protein kinase (MAPK)-dependent mechanism and 2) enhance myocardial functional recovery in a rat model of acute myocardial I/R injury. To study this, bone marrow MSCs were harvested from adult male mice (C57BL/6J) and treated in vitro for 24 h according to the following groups: 1) control, 2) TGF-alpha (250 ng mL (-1)), 3) TNF-alpha (50 ng mL (-1)), 4) TGF-alpha + TNF-alpha, 5) hypoxia, and 6) TGF-alpha + hypoxia. For the isolated heart perfusion experiments, adult male Sprague-Dawley rat hearts were isolated, perfused via the Langendorff model, and subjected to I/R. Vehicle or MSCs with or without TGF-alpha preconditioning were infused immediately before ischemia. Mesenchymal stem cells were also treated with TGF-alpha alone or in combination with a p38 MAPK inhibitor (SB202190). In vitro, TGF-alpha increased MSC VEGF production alone (157.9 +/- 1.11 - 291.0 +/- 3.74 pg 10 (-5); P < 0.05) and, to a greater extent, in combination with TNF-alpha or hypoxia (364.5 +/- 0.868 and 342.0 +/- 7.92 pg 10(-5) cells, respectively; P < 0.05 vs. TGF-alpha alone). Postischemic myocardial functional recovery was greater in hearts infused with TGF-alpha-preconditioned MSCs compared with untreated MSCs or vehicle. Myocardial IL-1beta and TNF-alpha production and activation of caspase 3 were significantly decreased after infusion of both cell groups. p38 MAPK inhibition suppressed TGF-alpha-stimulated MSC VEGF production and postischemic myocardial recovery. These results suggest that TGF-alpha stimulates MSC VEGF production in part via a p38 MAPK-dependent mechanism, and preconditioning MSCs with TGF-alpha may enhance their ability to protect myocardium during I/R injury.
Palladium‐Catalyzed Alkylation—Alkenylation Reactions: Rapid Access to Tricyclic Mescaline Analogues. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Three-dimensional quantitative coronary angiography (1990)

A method for reconstructing the three-dimensional coronary arterial tree structure from biplane two-dimensional angiographic images is presented. This method exploits the geometrical mathematics of X-ray imaging and the tracking of leading edges of injected contrast material into each vessel for identification of corresponding points on two images taken from orthogonal views. Accurate spatial position and dimension of each vessel in three-dimensional space can be obtained by this reconstruction procedure. The reconstructed arterial configuration is displayed as a shaded surface model, which can be viewed from various angles. Such three-dimensional vascular information provides accurate and reproducible measurements of vascular morphology and function. Flow measurements are obtained by tracking the leading edge of contrast material down the three-dimensional arterial tree. A quantitative analysis of coronary stenosis based on transverse area narrowing and regional blood flow, including the effect of vasoactive drugs, is described. Reconstruction experiments on actual angiographic images of the human coronary artery yield encouraging results toward a realization of computer-assisted three-dimensional quantitative angiography.
Organic Molecules Reconstruct Nanostructures on Ionic Surfaces (2011)

Modification and functionalization of the atomic-scale structure of insulating surfaces is fundamental to catalysis, self-assembly, and single-molecule technologies. Specially designed syn-5,10,15-tris(4-cyanophenylmethyl)truxene molecules can reshape features on an ionic KBr (001) surface. Atomic force microscopy images demonstrate that both KBr monolayer islands and pits can reshape from rectangular to round structures, a process which is directly facilitated by molecular adsorption. Simulations reveal that the mechanism of the surface reconstruction consists of collective atomic hops of ions on the step edges of the islands and pits, which correlate with molecular motion. The energy barriers for individual processes are reduced by the presence of the adsorbed molecules, which cause surface structural changes. These results show how appropriately designed organic molecules can modify surface morphology on insulating surfaces. Such strongly adsorbed molecules can also serve as anchoring sites for building new nanostructures on inert insulating surfaces.
Protein Kinase C-ε Regulates the Apoptosis and Survival of Glioma Cells (2005)

In this study, we examined the role of protein kinase C (PKC)-epsilon in the apoptosis and survival of glioma cells using tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-stimulated cells and silencing of PKCepsilon expression. Treatment of glioma cells with TRAIL induced activation, caspase-dependent cleavage, and down-regulation of PKCepsilon within 3 to 5 hours of treatment. Overexpression of PKCepsilon inhibited the apoptosis induced by TRAIL, acting downstream of caspase 8 and upstream of Bid cleavage and cytochrome c release from the mitochondria. A caspase-resistant PKCepsilon mutant (D383A) was more protective than PKCepsilon, suggesting that both the cleavage of PKCepsilon and its down-regulation contributed to the apoptotic effect of TRAIL. To further study the role of PKCepsilon in glioma cell apoptosis, we employed short interfering RNAs directed against the mRNA of PKCepsilon and found that silencing of PKCepsilon expression induced apoptosis of various glioma cell lines and primary glioma cultures. To delineate the molecular mechanisms involved in the apoptosis induced by silencing of PKCepsilon, we examined the expression and phosphorylation of various apoptosis-related proteins. We found that knockdown of PKCepsilon did not affect the expression of Bcl2 and Bax or the phosphorylation and expression of Erk1/2, c-Jun-NH2-kinase, p38, or STAT, whereas it selectively reduced the expression of AKT. Similarly, TRAIL reduced the expression of AKT in glioma cells and this decrease was abolished in cells overexpressing PKCepsilon. Our results suggest that the cleavage of PKCepsilon and its down-regulation play important roles in the apoptotic effect of TRAIL. Moreover, PKCepsilon regulates AKT expression and is essential for the survival of glioma cells.
Human papilloma virus (HPV) and carcinomas of the head and neck (1988)

Increasing evidence for a causal link between human papilloma virus and carcinomas of the cervix has emerged in recent research. This group of species-specific, epitheliotropic viruses has also been associated with tumours of the head and neck, but the individual reports deal only with relatively small sample numbers. In the present review these reports are considered in relation to the methods employed, and it is concluded that HPV is associated with more than 50% of oral and nasal carcinomas, as well as with carcinomas of the larynx and oesophagus. The clinical relevance and strategies for future work are outlined.
Breakable mesoporous silica nanoparticles for targeted drug delivery (2016)

"Pop goes the particle". Here we report on the preparation of redox responsive mesoporous organo-silica nanoparticles containing disulfide (S-S) bridges (ss-NPs) that, even upon the exohedral grafting of targeting ligands, retained their ability to undergo structural degradation, and increase their local release activity when exposed to a reducing agent. This degradation could be observed also inside glioma C6 cancer cells. Moreover, when anticancer drug-loaded pristine and derivatized ss-NPs were fed to glioma C6 cells, the responsive hybrids were more effective in their cytotoxic action compared to non-breakable particles. The possibility of tailoring the surface functionalization of this hybrid, yet preserving its self-destructive behavior and enhanced drug delivery properties, paves the way for the development of effective biodegradable materials for in vivo targeted drug delivery.
Multi-agent controlled building management system (2017)

A Building Management System is a Computer based system which can monitor and control different mechanical and electrical equipment in a building. A reliable, efficient and integrated controlling among these equipment's in a building is the main objective of a Building Management System. This paper presents a Multi Agent Controlled Building Management System which is controlled as an agent based integrated system of different subsystems such as Lighting, Security, Air-conditioning, Ventilation.
Safety and Efficacy of Mangafodipir Trisodium (MnDPDP) Injection for Hepatic MRI in Adults: Results of the U.S. Multicenter Phase III Clinical Trials (Safety) (2000)

The short-term safety of mangafodipir trisodium (MnDPDP) injection was studied in 546 adults with known or suspected focal liver lesions. An initial contrast-enhanced computed tomography examination was followed by unenhanced magnetic resonance imaging (MRI), injection of MnDPDP (5 micromol/kg), and enhanced MRI. Adverse events were reported for 23% of the patients; most were mild to moderate in intensity, did not require treatment, and were not drug related. The most commonly reported adverse events were nausea (7%) and headache (4%). The incidence of serious adverse events was low (nine events in six patients) and not drug related. Injection-associated discomfort was reported for 69% of the patients, and the most commonly reported discomforts included heat (49%) and flushing (33%). Changes in laboratory values and vital signs were generally transient, were not clinically significant, and did not require treatment. There were no clinically significant short-term risks from exposure to MnDPDP.
Analysis of the Innovation Trend in Cell-Free Synthetic Biology (2021)

Cell-free synthetic biology is a maturing field that aims to assemble biomolecular reactions outside cells for compelling applications in drug discovery, metabolic engineering, biomanufacturing, diagnostics, and education. Cell-free systems have several key features. They circumvent mechanisms that have evolved to facilitate species survival, bypass limitations on molecular transport across the cell wall, enable high-yielding and rapid synthesis of proteins without creating recombinant cells, and provide high tolerance towards toxic substrates or products. Here, we analyze ~750 published patents and ~2000 peer-reviewed manuscripts in the field of cell-free systems. Three hallmarks emerged. First, we found that both patent filings and manuscript publications per year are significantly increasing (five-fold and 1.5-fold over the last decade, respectively). Second, we observed that the innovation landscape has changed. Patent applications were dominated by Japan in the early 2000s before shifting to China and the USA in recent years. Finally, we discovered an increasing prevalence of biotechnology companies using cell-free systems. Our analysis has broad implications on the future development of cell-free synthetic biology for commercial and industrial applications.
Two New Algorithms for Indoor Wireless Positioning System (WPS) (2004)

WPS is a 100% pure software-based indoor positioning system which uses the signal strength of WLAN (Wireless Local Area Networks) infrastructure transmission from/to WLAN access points to determine the position of the user equipped with mobile computing devices such as Personal Digital Assistants (PDA), laptop computers and so on. In a previous paper (Wang, 2003), the authors gave a detailed description of their WPS system, including hardware, software and system architecture. Meanwhile, based on the WPS test bed, several basic experiments were conducted: (a) to determine the stability of the 2.4GHz WLAN infrastructure radio signal strength, (b) reliability experiment of the 2.4 GHz WLAN infrastructure radio Ssgnal, (c) verification of the empirical model and the effect of Geometry of Distribution (GOD), and (d) wall penetration loss experiment. From the results of these experiments and data analysis it was concluded that a wireless access pointbased indoor positioning system is feasible. Experimental results show a positioning accuracy of 1-3m. In order to improve the stability and reliability of the WPS system the authors propose two new methods. Thedifferential approach requires setting up a fixed differential correction base station in the same environment to compensate for the influence of susceptible radio frequency on the user device. In addition, from an analysis of positioning measurements, the authors determined that, to some extent, signal strength at one fixed position is having a trend of weakness, which means that the signal strength value always weakens when it is affected by a different environment factor. So, based on this observation, the authors propose a minimal signal strength value algorithm.