gebhart/patrepeval huggingface dataset:
Rate of CPAP Therapy Termination in Different Obstructive Sleep Apnoea Patient Phenotypes: Analysis of the French Nationwide Health Claims Database (2021)

RATIONALE Long-term adherence to continuous positive airway pressure (CPAP) remains an issue in patients with obstructive sleep apnea (OSA). The study investigated long-term CPAP termination rates, focusing on the contribution of specific comorbidities (COPD, diabetes, hypertension) to therapy termination. METHODS This analysis included data from the French national health insurance reimbursement system database for all new CPAP users aged 18 years during the period from January 2015 to December 2016. Algorithms were used to determine the presence of specific comorbidities. CPAP use and a diagnosis of OSA were identified by specific treatment modality and disease codes (ICD-10 code). CPAP therapy termination was defined as the cessation of CPAP reimbursements triggered by the respiratory physician or sleep specialist in charge of follow-up. Rates of CPAP therapy termination were compared using Kaplan-Meier survival analysis with Log-Rank test. RESULTS 480,000 patients were included (mean age 59.313.6 years, 65.4% male). Hypertension, diabetes and COPD were present in 50.7%, 24.4% and 4.3% of patients, respectively. Overall CPAP therapy termination rates after 1, 2 and 3 years were 23.1%, 37.1% and 47.7%, respectively. On multivariable analysis, age <41 years (adjusted hazard ratio [95% confidence interval] 1.65 [1.62-1.68]), age >80 years (1.44 [1.41-1.47]), and ) and diabetes (1.10 [1.09-1.11]) were significantly associated with a higher risk of CPAP termination; patients with hypertension were more likely to continue using CPAP (hazard ratio 0.95 [95% confidence interval 0.94-0.96]). Risk of therapy termination was highest in younger or older patients with >1 comorbidity. (Figure In addition to age and gender, there was a clear and significant association between the presence of selected comorbidities and the risk of terminating CPAP therapy. The combination of young age, female sex and comorbid diabetes or COPD was most closely associated with CPAP therapy termination. Therefore, patient phenotyping and personalized care approaches should be important features of an integrated OSA management strategy.
Authors' reply: A critical blood pressure value should be determined in trauma patients who underwent aortic occlusion with REBOA (2021)

Ordoñez, Carlos A. MD; Rodríguez, Fernando MD; Orlas, Claudia P. MD; Parra, Michael W. MD, FACS; Caicedo, Yaset MD; Guzmán, Mónica MD, MSc; Serna, José J. MD; Salcedo, Alexander MD; Zogg, Cheryl K. MSPH, MHS; Herrera-Escobar, Juan P. MD, MPH; Meléndez, Juan J. MD; Angamarca, Edison MD; Serna, Carlos A. MD; Martínez, Diana MSc; García, Alberto F. MD, MSc; Brenner, Megan MD, MScAuthor Information
The Na + /I − symporter (NIS) transports two of its substrates, I − and ClO 4 − , with different stoichiometries (2007)

RNA sequencing (RNA-seq) has become a powerful tool to understand molecular mechanisms and/or developmental programs. It provides a fast, reliable and cost-effective method to access sets of expressed elements in a qualitative and quantitative manner. Especially for non-model organisms and in absence of a reference genome, RNA-seq data is used to reconstruct and quantify transcriptomes at the same time. Even SNPs, InDels, and alternative splicing events are predicted directly from the data without having a reference genome at hand. A key challenge, especially for non-computational personnal, is the management of the resulting datasets, consisting of different data types and formats. Here, we present TBro, a flexible de novo transcriptome browser, tackling this challenge. TBro aggregates sequences, their annotation, expression levels as well as differential testing results. It provides an easy-to-use interface to mine the aggregated data and generate publication-ready visualizations. Additionally, it supports users with an intuitive cart system, that helps collecting and analysing biological meaningful sets of transcripts. TBro's modular architecture allows easy extension of its functionalities in the future. Especially, the integration of new data types such as proteomic quantifications or array-based gene expression data is straightforward. Thus, TBro is a fully featured yet flexible transcriptome browser that supports approaching complex biological questions and enhances collaboration of numerous researchers. DATABASE URL: : tbro.carnivorom.com.
Degenerative Arthritis of the Knee in Active Patients: Evaluation and Management (1999)

The natural history and treatment of degenerative arthritis of the knee in active patients is a topic of great interest, with continually evolving concepts and techniques. Osteoarthritis is a spectrum of clinical entities, ranging from focal chondral defects to established arthrosis resulting from biologic and biomechanical hyaline cartilage failure. Evaluation of the active patient with knee arthritis should include a comprehensive history emphasizing symptom manifestation, activity level, and previous surgical treatment. The physical examination must include an evaluation of extremity alignment, gait patterns, and coexisting disorders of the spine and adjacent joints. Diagnostic testing is usually straightforward and should include the 45-degree flexion weight-bearing posteroanterior plain radiograph. Nonsurgical treatment modalities include rehabilitation, lifestyle modification, bracing, supportive devices, and medical management, including use of the new chondroprotective oral and injectable agents. Several surgical options exist, each with specific indications. Arthroscopic debridement can provide a positive, but often short-lived, reduction in the severity of symptoms. Tibial or femoral osteotomy may maintain the patient's active lifestyle and delay the need for arthroplasty. Unicompartmental and total knee arthroplasty can each provide reliable relief of symptoms but may not permit a return to the activities that the patient values.
Power Law Rheology of Folded Protein Hydrogels (2022)

Folded protein hydrogels are prime candidates as tuneable biomaterials but it is unclear to what extent their mechanical properties have mesoscopic, as opposed to molecular origins. To address this, we probe hydrogels of the muscle-derived protein $I27_5$, using a multimodal rheology approach. Across multiple protocols, the hydrogels consistently exhibit power-law viscoelasticity in the linear viscoelastic regime with an exponent $β= 0.03$, suggesting a dense fractal meso-structure, with predicted fractal dimension $d_f = 2.48$. In the nonlinear viscoelastic regime, the hydrogel undergoes stiffening and energy dissipation, indicating simultaneous alignment and unfolding of the folded proteins. Remarkably, this behaviour is highly reversible, as the value of $β$, $d_f$ and the viscoelastic moduli return to their equilibrium value, even after multiple cycles of deformation. This highlights a previously unrevealed diversity of viscoelastic properties that originate on the mesoscopic scale. These considerations are likely to be key to controlling the viscoelasticity of folded protein hydrogels.
The CHA2DS2-VASc score identifies those patients with atrial fibrillation and a CHADS2 score of 1 who are unlikely to benefit from oral anticoagulant therapy (2012)

The CHA(2)DS(2)-VASc score reclassifies 26% of patients with a CHADS(2) score of 1 to a low annual risk of SSE of 1%. This risk seems low enough to consider withholding anticoagulant treatment.
Exposure of Domestic Mammals to West Nile Virus during an Outbreak of Human Encephalitis, New York City, 1999 (2001)

We evaluated West Nile (WN) virus seroprevalence in healthy horses, dogs, and cats in New York City after an outbreak of human WN virus encephalitis in 1999. Two (3%) of 73 horses, 10 (5%) of 189 dogs, and none of 12 cats tested positive for WN virus-neutralizing antibodies. Domestic mammals should be evaluated as sentinels for local WN virus activity and predictors of the infection in humans.
Large gauge factor of hot wire chemical vapour depositionin-situboron doped polycrystalline silicon (2016)

Polysilicon piezoresistors with a large longitudinal gauge factor (GF) of 44 have been achieved using in-situ boron doped hot-wire chemical vapour deposition (HWCVD). This GF is a consequence of a high quality p-type doped polysilicon with a crystal volume of 97% and an average grain size of 150 nm, estimated using Raman spectroscopy and atomic force microscopy (AFM) respectively. The measured minimum Hooge factor associated to the 1/f noise of the polysilicon piezoresistors is 1.4 × 10&lt;sup&gt;−3&lt;/sup&gt;. These results indicate that HWCVD polysilicon is a suitable piezoresistive material for micro-electro-mechanical systems (MEMS) applications.
A narrow-band subwavelength plasmonic waveguide filter with asymmetrical multiple-teeth-shaped structure (2009)

Characteristics of a multiple-teeth-shaped plasmonic filter are analyzed. As an extension of this structure, an asymmetrical multiple-teeth-shaped structure is proposed and numerically simulated by using the finite difference time domain method with perfectly matched layer absorbing boundary condition. It is found that the asymmetrical structure can realize the function of a narrow-passband filter. The central wavelength of the passband linearly increases with the simultaneous increasing of d(1) and d(2).
Stereoselective synthesis of vinylphosphonates and phosphine oxides via silver-catalyzed phosphorylation of styrenes (2015)

An efficient and stereoselective synthesis of vinylphosphonates and phosphine oxides was developed starting from styrenes using AgNO3 as the catalyst and K2S2O8 as the oxidant. The success of the reaction was found to be critically dependent on the use of TEMPO as the additive.
High-Order Harmonic Generation and Quasiphase Matching in Xenon Using Self-Guided Femtosecond Pulses (1998)

Ultrashort self-guided laser pulses are employed to generate high-order harmonics in noble gases. Interference fringes between fundamental and harmonic waves over several cm reveal a long range longitudinal coherence of the generated harmonics. Quasiphase matching is demonstrated for the third harmonic wave.
Birth Control after 1984 (1970)

1) Eric Blair (alias George Orwell) can rest easy in his grave, because birth control by governmentally imposed methods, such as incorporation of a contraceptive agent into drinking water, is totally unfeasible by 1984. 2) Fundamentally new birth control procedures in the female (for example, a once-a-month luteolytic or abortifacient agent) and a male contraceptive pill probably will not be developed until the 1980's at the earliest, and then only if major steps of the type outlined in this article are instituted in the early 1970's. Development during the next decade of practical new methods of birth control without important incentives for continued active participation by the pharmaceutical industry is highly unlikely. If none are developed, birth control in 1984 will not differ significantly from that of today.
Modified MILP model for scheduling of sequential multipurpose batch plants (2006)

Sequential multipurpose batch processes are common in many fine chemical manufacturing plants, such as traditional paint, food, pharmaceuticals,and specialty chemicals plants. The investigation in this paper includes analyzing the operational features of sequential multipurpose batch plants, decomposing the overall batch process spatially into several sub-systems, and presenting a modified MILP formulation for the scheduling of sequential multipurpose batch plants with continuous-time approaches. As the bi-index binary variables are substituted for the tri-index binary variables in the MILP model, the number of discrete variables decreases substantially. The new model is effective in solving large scale scheduling problems. In case studies, the proposed model was compared with the previous model presented by Voudouris and Grossmann. Moreover, several large scale scheduling problems were solved successfully with the proposed modeling approaches. These case studies prove the validity of the model and the practicability of the proposed approaches.
Les cyberassurances résisteront-elles à la première (vraie) attaque (mondiale) ? (2019)

info:eu-repo/semantics/published
Studies of Cultured Human T Lymphocytes II. Initiation of Paired T- and B-Cell Lines from Healthy Donors (1983)

We report the sustained cultivation of both B- and T-lymphoblastoid cell lines from randomly selected healthy donors, and the results of studies defining the frequency with which these cell lines can be established. B-cell lines were initiated using the Epstein-Barr virus. Of 52 attempts, 40 B-cell lines (77% success) were obtained from 24 different donors. T-cell lines were started and propagated in long-term (greater than 100 days) cultures using the T-cell growth factor interleukin-2 (IL-2). Of 55 attempts, 54 (98%) were successful in initiating IL-2-dependent T-cell lines, and these were derived from 28 healthy adults. Likewise, of 45 attempts, 32 (71%) were successful in producing paired lines in which both the B-cell line and T-cell line were cultivated from a single blood collection (N = 22 donors). Phenotypic profiles of these lines were defined using multiple marker assays, including rosette formation, surface immunoglobulins, cytochemistry, karyotype, as well as xenoantisera and monoclonal antibodies defining different membrane antigens. This work demonstrates the feasibility of propagating paired human B and T lymphoblastoid lines suitable for many comparative immunobiological studies.
Coding Methods for the NMF Approach to Speech Recognition and Vocabulary Acquisition (2011)

This paper aims at improving the accuracy of the non- negative matrix factorization approach to word learn- ing and recognition of spoken utterances. We pro- pose and compare three coding methods to alleviate quantization errors involved in the vector quantization (VQ) of speech spectra: multi-codebooks, soft VQ and adaptive VQ. We evaluate on the task of spotting a vocabulary of 50 keywords in continuous speech. The error rates of multi-codebooks decreased with increas- ing number of codebooks, but the accuracy leveled off around 5 to 10 codebooks. Soft VQ and adaptive VQ made a better trade-off between the required memory and the accuracy. The best of the proposed methods reduce the error rate to 1.2% from the 1.9% obtained with a single codebook. The coding methods and the model framework may also prove useful for applica- tions such as topic discovery/detection and mining of sequential patterns.
Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor (2016)

Benzoquinazolinone 1 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR), which is significantly more potent than the prototypical PAM, 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (BQCA). In this study, we explored the structural determinants that underlie the activity of 1 as a PAM of the M1 mAChR. We paid particular attention to the importance of the tricyclic scaffold of compound 1, for the activity of the molecule. Complete deletion of the peripheral fused benzene ring caused a significant decrease in affinity and binding cooperativity with acetylcholine (ACh). This loss of affinity was rescued with the addition of either one or two methyl groups in the 7- and/or 8-position of the quinazolin-4(3H)-one core. These results demonstrate that the tricyclic benzo[h]quinazolin-4(3H)-one core could be replaced with a quinazolin-4(3H)-one core and maintain functional affinity. As such, the quinazolin-4(3H)-one core represents a novel scaffold to further explore M1 mAChR PAMs with improved physicochemical properties.
Levels of Circulating miR‐122 are Associated with Weight Loss and Metabolic Syndrome (2020)

Changes in circulating miR-122-5p, miR-126a-3p, miR-193a-5p, and miR-222-3p in response to diet-induced weight loss are demonstrated. Furthermore, assessment of miR-122-5p could be an indicator of an adverse metabolic health status independent of obesity.
Immunization strategies forClostridium difficileinfections (2012)

Clostridium difficile infection is a major cause of nosocomial disease in Western countries. The recent emergence of hypervirulent strains resistant to most antibiotics correlates with increasing disease incidence, severity and lethal outcomes. Current treatments rely on metronidazol and vancomycin, but the limited ability of these antibiotics to cure infection and prevent relapse highlights the need for new strategies. A better knowledge of the molecular mechanisms of the disease, the host immune response and identification of key virulence factors of Clostridium difficile now permits the development of new products specifically targeting the pathogen. Immune-based strategies relying on active vaccination or passive administration of antibody products are the focus of intense research and, today, the efficacy of monoclonal antibodies and of two vaccines are evaluated clinically. This review presents recent data, discusses the different strategies and highlights the challenges linked to the development of immunization strategies against this emerging threat.
Role of Endothelium in the Response to Prostaglandin H2 in Isolated Dog Arteries (1989)

Prostaglandin (PG) H2 produced a transient contraction followed by a relaxation in helical strips of dog coronary, mesenteric and renal arteries contracted with PGF2a. The contraction was in the order of mesenteric>renal>coronary artery. Removal of endothelium abolished the contraction in these arteries and significantly potentiated the relaxation only in mesenteric arteries. The relaxation was greater in mesenteric arteries than in renal and coronary arteries, denuded of endothelium. PGI2-induced relaxations were not influenced by endothelium denudation. In the arteries contracted with K+, PGH2-induced relaxations were attenuated, compared to those contracted with PGF2a. Treatment with ONO3708, an antagonist of vasoconstrictor PGs, abolished the PGH2-induced contraction and potentiated the relaxation in the K+-contracted arteries. The relaxant response was suppressed by diphloretin phosphate, a PG receptor antagonist, as was the response to PGI2. PGH2-induced contractions in dog coronary, mesenteric and renal arteries would be due to vasoconstrictor PGs produced preferentially in the endothelium. However, production of PGI2 from PGH2 in endothelial and subendothelial tissues do not appear to differ.
The roles of polymer relaxation phenomena, aqueous dye solubility and the physical properties of water in the mechanism of adsorption of a disperse dye on poly(ethylene terephthalate) fibres: Part 4 further aspects related to polymer relaxation phenomena (2023)

Abstract To further investigate the contribution of polymer relaxation times to the mechanism of disperse dye adsorption on poly(ethylene terephthalate) fibres, the temperature‐dependent uptake of Teratop Yellow HL‐G 150% on both cotton and polyamide 66 fabrics at temperatures between 30 and 130°C was compared with that on poly(ethylene terephthalate) fabric. Although uptake of the commercial grade dye on polyester fabric is governed by the thermally regulated, broad glass transition of the water‐saturated poly(ethylene terephthalate) substrate, as this was not observed for either cotton or nylon 66 fabrics, the respective cellulose or polyamide 66 polymer glass transition does not present a major thermal impediment to dye uptake over the wide range of dyeing temperatures used. This is because the onset and end‐set temperatures of the glass transition of the water‐plasticised poly(ethylene terephthalate) material reside within the range of dyeing temperatures employed, whereas those of the water‐plasticised cotton and polyamide materials occur below the lowest dyeing temperature examined (30°C). The thermal dependency of disperse dye solubility also likely makes a meaningful contribution to the temperature‐dependent dye uptake observed for each type of fibre.
FTIR study of the surface-ligand exchange reaction with glutathione on biocompatible rod-shaped CdSe/CdS semiconductor nanocrystals (2022)

Semiconductor nanocrystals (SNCs) are an essential optical tool in life sciences. Application of SNCs to living systems requires that their surfaces be covered with biocompatible molecules. The surface capping of SNCs by glutathione (GSH) is an effective means to prepare biocompatible SNCs and involves replacement of the initial surface ligands with GSH. However, molecular insight into such ligand-exchange reactions remains elusive. Molecular insight into this process is important, because surface ligands significantly impact physical properties such as the stability and quantum yield of SNCs. In this study, we investigate the ligand-exchange reaction of GSH on rod-shaped CdSe/CdS SNCs by Fourier-transform infrared (FTIR) absorption spectroscopy. The structure and interactions of GSH on SNC surfaces are clarified. Quantitative determination of the GSH molar fraction on SNC surfaces reveals that ∼3% of the initial trioctylphosphine oxide (TOPO) ligand is retained. Concentration-dependent experiments show that the surface molar fraction of GSH impacts the physical properties, solubilization yields, and quantum yields of SNCs in a linear manner.
CiNCT: Compression and retrieval for massive vehicular trajectories via relative movement labeling (2017)

In this paper, we present a compressed data structure for moving object trajectories in a road network, which are represented as sequences of road edges. Unlike existing compression methods for trajectories in a network, our method supports pattern matching and decompression from an arbitrary position while retaining a high compressibility with theoretical guarantees. Specifically, our method is based on FM-index, a fast and compact data structure for pattern matching. To enhance the compression, we incorporate the sparsity of road networks into the data structure. In particular, we present the novel concepts of relative movement labeling and PseudoRank, each contributing to significant reductions in data size and query processing time. Our theoretical analysis and experimental studies reveal the advantages of our proposed method as compared to existing trajectory compression methods and FM-index variants.
Ultra-Wideband Antenna Design for GPR Applications: A Review (2017)

This paper presents a comparative review study on ultra-wideband (UWB) antenna technology for Ground Penetrating Radar (GPR) applications. The proposed antenna designs for UWB ground penetrating radar include a bow-tie antennas, Vivaldi antennas, horn antennas, planar antennas, tapered slot antennas, dipole antennas, and spiral antennas. Furthermore a comprehensive study in terms of operating frequency range, gain and impedance bandwidth on each antenna is performed in order to select a suitable antenna structure to analyze it for GPR systems. Based on the design comparison, the antenna with a significant gain and enhanced bandwidth has been selected for future perspective to examine the penetration depth and resolution imaging, simultaneously suitable for GPR detection applications. Three different types of antennas are chosen to be more suitable from the final comparison which includes Vivaldi, horn and tapered slot antennas. On further analysis a tapered slot antenna is a promising candidate as it has the ability to address the problems such as penetration depth and resolution imaging in GPR system due to its directional property, high gain and greater bandwidth operation, both in the lower and higher frequency range.
Prognostic Value of a Quantitative Analysis of Lipoarabinomannan in Urine from Patients with HIV-Associated Tuberculosis (2014)

In patients with HIV-associated TB, concentrations of LAM in urine were strongly associated with a range of poor prognostic characteristics known to be associated with mortality risk. Urine LAM assays with a semi-quantitative (negative vs. low-positive vs. high-positive) read-out may have improved clinical utility over assays with a simple binary result.