gebhart/patrepeval huggingface dataset:
Gingival overgrowth induced by different dosages of cyclosporin in rats. (1995)

Because of a significant correlation between CSA-induced gingival overgrowth and CSA dosage, the dose effect on the severity of this gingival overgrowth was established in the rat model.
Osmotic Blistering in Enamel Bonded with One-step Self-etch Adhesives (2004)

One-step self-etch adhesives behave as permeable membranes after polymerization, permitting water to move through the cured adhesives. We hypothesize that osmotic blistering occurs in bonded enamel when these adhesives are used without composite coupling. Tooth surfaces from extracted human premolars were bonded with 5 one-step self-etch adhesives. They were immersed in distilled water or 4.8 M CaCl(2), and examined by stereomicroscopy, field-emission/environmental SEM, and TEM. Water blisters were observed in bonded enamel but not in bonded dentin when specimens were immersed in water. They collapsed when water was subsequently replaced with CaCl(2). Blisters were absent from enamel in specimens that were immersed in CaCl(2) only. Water trees were identified from adhesive-enamel interfaces. Osmotic blistering in enamel is probably caused by the low water permeability of enamel. This creates an osmotic gradient between the bonded enamel and the external environment, causing water sorption into the interface.
On the development of a semi-submersible offshore floating platform and mooring system for a 13.2 mw wind turbine (2016)

Over the past decades, wind energy has emerged as an alternative to conventional power generation that is economical, environmentally friendly, and importantly renewable. Specifically, offshore wind energy is being con- sidered by a number of countries to harness the stronger and more consistent wind resource compared to that over land. To meet the projected “20% energy from wind by 2030” scenario that was announced in 2006, 54 GW of added wind energy capacity needs to come from offshore according to a National Renewable Energy Laboratory (NREL) study.\nIn this study, we discuss the development of a semi-submersible floating offshore platform with a catenary mooring system to support a very large\nvi\n13.2 MW wind turbine with 100 m blades. An iterative design process is applied to baseline models with Froude scaling in order to achieve preliminary static stability. Structural dynamic analyses are performed to investigate the performance of the new model using a finite element method approach for the tower and a boundary integral equation (panel) method for the platform. The steady-state response of the system under uniform wind and regular waves is first studied to evaluate the performance of the integrated system. Response amplitude operators (RAOs) are computed in the time domain using white- noise wave excitation; this serves to highlight nonlinear as well as dynamic characteristics of the system. Finally, the stochastic dynamic response of the system is studied to assess the global performance for sea states defined by wind fields with turbulence and long-crested irregular waves.
G protein subunits and the stimulation of phospholipase C by Gs-and Gi-coupled receptors: Lack of receptor selectivity of Galpha(16) and evidence for a synergic interaction between Gbeta gamma and the alpha subunit of a receptor activated G protein. (1996)

Stimulatory guanine nucleotide binding protein (Gs)-coupled receptors activated by luteinizing hormone, vasopressin, and the catecholamine isoproterenol (luteinizing hormone receptor, type 2 vasopressin receptor, and types 1 and 2 beta-adrenergic receptors) and the Gi-coupled M2 muscarinic receptor (M2R) were expressed transiently in COS cells, alone and in combination with Gbeta gamma dimers, their corresponding Galphas (Galpha(s), or Galpha(i3)) and either Galpha(q) or Galpha(16). Phospholipase C (PLC) activity, assessed by inositol phosphate production from preincorporated myo[3H]inositol, was then determined to gain insight into differential coupling preferences among receptors and G proteins. The following were observed: (i) All receptors tested were able to stimulate PLC activity in response to agonist occupation. The effect of the M2R was pertussis toxin sensitive. (ii) While, as expected, expression of Galpha(q) facilitated an agonist-induced activation of PLC that varied widely from receptor to receptor (400% with type 2 vasopressin receptor and only 30% with M2R), expression of Galpha(16) facilitated about equally well the activation of PLC by any of the tested receptors and thus showed little if any discrimination for one receptor over another. (iii) Gbeta gamma elevated basal (agonist independent) PLC activity between 2- and 4-fold, confirming the proven ability of Gbeta gamma to stimulate PLCbeta. (iv) Activation of expressed receptors by their respective ligands in cells coexpressing excess Gbeta gamma elicited agonist stimulated PLC activities, which, in the case of the M2R, was not blocked by pertussis toxin (PTX), suggesting mediation by a PTX-insensitive PLC-stimulating Galpha subunit, presumably, but not necessarily, of the Gq family. (v) The effects of Gbeta gamma and the PTX-insensitive Galpha elicited by M2R were synergistic, suggesting the possibility that one or more forms of PLC are under conditional or dual regulation of G protein subunits such that stimulation by one sensitizes to the stimulation by the other.
Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials (2021)

Major progress in the field of regenerative medicine is expected from the design of artificial scaffolds that mimic both the structural and functional properties of the ECM. The bionanocomposites approach is particularly well fitted to meet this challenge as it can combine ECM-based matrices and colloidal carriers of biological cues that regulate cell behavior. Here we have prepared bionanocomposites under high magnetic field from tilapia fish scale collagen and multifunctional silica nanoparticles (SiNPs). We show that scaffolding cues (collagen), multiple display of signaling peptides (SiNPs) and control over the global structuration (magnetic field) can be combined into a unique bionanocomposite for the engineering of biomaterials with improved cell performances.
Sectorized Antenna-based DoA Estimation and Localization: Advanced Algorithms and Measurements (2015)

Sectorized antennas are a promising class of antennas for enabling direction-of-arrival (DoA) estimation and successive transmitter localization. In contrast to antenna arrays, sectorized antennas do not require multiple transceiver branches and can be implemented using a single RF front-end only, thus reducing the overall size and cost of the devices. However, for good localization performance the underlying DoA estimator is of uttermost importance. In this paper, we therefore propose a novel high performance DoA estimator for sectorized antennas that does not require cooperation between the transmitter and the localizing network. The proposed DoA estimator is broadly applicable with different sectorized antenna types and signal waveforms, and has low computational complexity. Using computer simulations, we show that our algorithm approaches the respective Cramer-Rao lower bound for DoA estimation variance if the signal-to-noise ratio (SNR) is moderate to large and also outperforms the existing estimators. Moreover, we also derive analytical error models for the underlying DoA estimation principle considering both free space as well as multipath propagation scenarios. Furthermore, we also address the fusion of the individual DoA estimates into a location estimate using the Stansfield algorithm and study the corresponding localization performance in detail. Finally, we show how to implement the localization in practical systems and demonstrate the achievable performance using indoor RF measurements obtained with practical sectorized antenna units.
Clinical significance of circulating tumor cells after chemotherapy in unresectable pancreatic ductal adenocarcinoma (2021)

Circulating tumor cells (CTCs) have emerged as liquid biopsy biomarker providing non-invasive assessment of cancer progression and biology. We investigated whether longitudinal analysis of CTCs could monitor disease progression, response to chemotherapy, and survival in patients with unresectable pancreatic ductal adenocarcinoma (PDAC). A total of 52 patients with PDAC were prospectively enrolled in this study. Peripheral blood samples were serially collected at the time of diagnosis and after chemotherapy with clinical assessments. CTCs were isolated through a centrifugal microfluidic disc, enumerated with immunostaining against Epithelial cell adhesion molecule (EpCAM), Cytokeratin (CK), Plectin-1 and CD45, and identified by an automated imaging system. One or more CTCs were detected in 84.62% patients with unresectable PDAC at the time of diagnosis. CTC numbers were not statistically different across tumor sizes, location and metastatic sites. The absolute number of CTCs after chemotherapy was inversely related to overall survival (OS), and the decreased number of CTCs after chemotherapy was significantly associated with longer OS in patients with PDAC. Identifying CTCs and monitoring CTC changes after chemotherapy could be a useful prognostic marker for survival in patients with unresectable PDACs.
Biosynthetic relationships between three rat apolipoprotein B peptides (1988)

Rat liver is unique in secreting very low density lipoproteins (VLDL) with three size-isoforms of apolipoprotein B: PI and PIII correspond to B-100 and B-48, respectively, while PII is slightly smaller than PI and has no counterpart in other species. Antibodies against a fusion protein corresponding to the extreme C-terminal region of PI fail to react with PII, suggesting that the latter lacks this moiety. [35S]Methionine-labeled perfused rat liver and isolated hepatocytes secrete labeled PII, but intracellular apoB contains only PI and PIII. The absence of labeled PII from Golgi VLDL, and the absence of continued PII production within the plasma compartment, strongly suggest that PIII-containing VLDL are formed by a one-time proteolytic processing of a certain proportion of PI-containing VLDL at the time of secretion. In contrast, polysome run-off translation experiments and analysis of polysome-bound nascent apoB chains show that both rat liver and intestinal polysomes release PIII-sized peptides directly at the appropriate point of elongation, in a manner incompatible with their formation by posttranslational processing. These results strongly suggest that the large (PI, B-100) and small (PIII, B-48) apoB peptides are translated from separate mRNAs. Thus, although both PII and PIII are C-terminally truncated products of PI, the mechanisms involved are entirely different.
G protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle. (1991)

The mechanism of G protein-mediated sensitization of the contractile apparatus of smooth muscle to Ca2+ was studied in receptor-coupled alpha-toxin-permeabilized rabbit portal vein smooth muscle. To test the hypothesis that Ca2+ sensitization is due to inhibition of myosin light-chain (MLC) phosphatase activity, we measured the effect of guanosine 5'-[gamma-thio]triphosphate and phenylephrine on the rate of MLC dephosphorylation in muscles preactivated with Ca2+ and incubated in Ca(2+)- and ATP-free solution containing 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine (ML-9) to block MLC kinase activity. Guanosine 5'-[gamma-thio]triphosphate alone (300 microM) or in combination (3 microM) with phenylephrine decreased the rates of relaxation and dephosphorylation of MLC to about half of control values; this inhibition is sufficient to account for maximal G protein-mediated Ca2+ sensitization of MLC phosphorylation. The rate of thiophosphorylation of MLC with adenosine 5'-[gamma-thio]-triphosphate was not affected by guanosine 5'-[gamma-thio]triphosphate. We suggest that inhibition of protein phosphatase(s) by G protein(s) may have important regulatory functions.
ChemInform Abstract: Spectroscopic Studies of N‐S‐O Anions: The Reactions of NSO‐ with Elemental Sulfur and with S4N4 (1990)

Abstract (UV/VIS, IR, Raman, 14N, 17 O and 33 S NMR).
Multiparametric gas sensors with porous silicon optical microcavities (2002)

We show that porous silicon optical microcavities can be effectively used as multiparametric gas sensors. Beside the electrical conduction, interesting gas-sensing parameters of porous silicon microcavities are the photoluminescence intensity and the spectral position of the resonance cavity peak, which depends on the index of refraction of the surrounding gas. The dynamic response of the peak shift is also discussed.
Fatal cross infection by carbapenem‐resistant Klebsiella in two liver transplant recipients (2009)

Members of the family Enterobacteriaceae including Klebsiella have re-emerged as major pathogens in solid organ transplantation. The recent appearance and dissemination of carbapenemase-producing Enterobacteriaceae in Europe and the northeastern United States represents a major challenge to the treatment of enteric gram-negative bacterial infections in immunocompromised patients; however, few reports have detailed the outcomes of such infections. Here we report 2 cases of Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella infections in orthotopic liver transplant recipients, which were the index case and initial secondary case for an outbreak of KPC-producing Enterobacteriaceae in our institution. In both instances, the pathogens were initially misidentified as being carbapenem sensitive, the infections recurred after cessation of directed therapy, and the patients ultimately succumbed to their infections.
Secrecy Performance Analysis of Cooperative Nonorthogonal Multiple Access in IoT Networks (2022)

Differentsystemmodels utilizing nonorthogonal multiple access (NOMA) have been successfully studied to meet the growing capacity demands of the Internet of Things IoT) devices for the next-generation networks. However, analyzing the antieavesdropping for NOMA systems under different scenarios and settings still needs further exploration before it can be practically deployed. Therefore, in this article, we study the secrecy performance of a cooperative NOMA system in the IoT networks where two source nodes communicate with their respective destination nodes via a common relay in the presence of an eavesdropper. Specifically, two source nodes send their data in parallel over the same frequency band to the common relay node using uplink NOMA. Then, the relay node forwards the decoded symbols to the respective destination nodes using downlink NOMA in the presence of an eavesdropper. To enhance the security performance of the considered system, we study and propose an artificial noise (AN)-aided scheme in which the two destination nodes emit a jamming signal to confuse the eavesdropper while receiving the signal from the common relay node. We also study the effect of NOMA power allocation, perfect successive interference cancellation (pSIC), and imperfect successive interference cancellation (ipSIC) on the considered system. Analytical expressions for the ergodic capacity (EC), ergodic secrecy sum rate (ESSR), and secrecy outage probability (SOP) are mathematically derived and verified with the simulation results. Our results demonstrate that a significantly higher ESSR and lower SOP of the system can be attained compared to a conventional NOMA system without a destination-assisted jamming signal scheme.
Gram-Scale, Low Temperature, Sonochemical Synthesis of Stable Amorphous Ti–B Powders Containing Hydrogen (2017)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTGram-Scale, Low Temperature, Sonochemical Synthesis of Stable Amorphous Ti–B Powders Containing HydrogenZachary J. Huba†, Martin D. Donakowski†, and Albert Epshteyn‡*View Author Information Chemistry Division, U.S. Naval Research Laboratory, Washington, D.C. 20375, United States*(A.E.) E-mail: [email protected]Cite this: Chem. Mater. 2017, 29, 4, 1467–1471Publication Date (Web):February 10, 2017Publication History Received1 February 2017Revised9 February 2017Published online15 February 2017Published inissue 28 February 2017https://pubs.acs.org/doi/10.1021/acs.chemmater.7b00431https://doi.org/10.1021/acs.chemmater.7b00431rapid-communicationACS PublicationsCopyright © 2017 American Chemical SocietyRequest reuse permissionsArticle Views436Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Granular materials,Heat treatment,Organic reactions,Oxidation,Redox reactions Get e-Alerts
Contract Formation and Modification Under Revised Article 2 (1994)

Study Group on Article 2 of the Uniform Commercial Code.'In this three-year project, the Study Group attempted to identify major problems of practical importance in Article 2 and to recommend possible revisions.The Study Group solicited comments from over three hundred interested persons and organizations and received over fifty responses.In March 1991, the Study Group submitted an Executive Summary to the PEB and unanimously recommended
uFLIM -- Unsupervised analysis of FLIM-FRET microscopy data (2021)

Despite their widespread use in cell biology, fluorescence lifetime imaging microscopy (FLIM) data-sets are challenging to analyse, because each spatial position can contain a superposition of multiple fluorescent components. Here, we present a data analysis method employing all information in the available photon budget, as well as being fast. The method, called uFLIM, determines spatial distributions and temporal dynamics of multiple fluorescent components with no prior knowledge. It goes significantly beyond current approaches which either assume the functional dependence of the dynamics, e.g. an exponential decay, or require dynamics to be known, or calibrated. Its efficient non-negative matrix factorization algorithm allows for real-time data processing. We validate in silico that uFLIM is capable to disentangle the spatial distribution and spectral properties of five fluorescing probes, from only two excitation and detection channels and a photon budget of 100 detected photons per pixel. By adapting the method to data exhibiting Forster resonant energy transfer (FRET), we retrieve the spatial and transfer rate distribution of the bound species, without constrains on donor and acceptor dynamics.
El Teorema de Fermat y sus Historias (2006)

La demostracion del ultimo teorema de Fermat (UTF) a manos de Andrew Wiles, completada en 1994, fue uno de los logros matematicos mas prominentes de finales del siglo pasado, y sin duda uno de los eventos cientificos que recibio la mayor atencion de los medios de comunicacion y del publico general. No todos los dias se resuelve un problema que ha estado abierto por mas de 350 anos y no todos los dias se reporta el trabajo esoterico de un matematico puro en la primera plana del New York Times.
Error analysis of the wave directional spectrum measurement by Disc Buoys (2003)

Data buoys, which have the characteristics of comparative reliability and robustness, are the most frequently applied devices for the measurement of oceanographical data. The objective of the present study is to improve the accuracy of directional spectra measurement and analyseis. In order to improve the accuracy of directional estimation, a proposed method is developed based on Maximum heave/pitch quad-spectrum method. The response gain factor and phase lag can be merged into the directional spectrum estimator to reduce errors. The new method is then validated by numerical simulations. The results demonstrate that the difference of the main direction between the target and the output ranges from 0 to 20 degrees when the method is applied to the field wave data.
Tb3O2Cl[SeO3]2 and Tb5O4Cl3[SeO3]2: Oxide Chloride Oxoselenates(IV) of Trivalent Terbium with “Lone‐Pair” Channel or Layer Structures. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Generalized Fokker-Planck models of light propagation in layered media (2009)

We present a numerical procedure using the PN-method to model light distributions in layered structures such as the epithelium. In contrast to previous studies of layered media using Monte Carlo methods and discrete ordinates, the PN-method provides the flexibility to not only vary tissue optical properties across layers but also allows one to vary the tissue light interaction without changes to the numerical method. This includes the collection of generalized Fokker-Planck equations used in forward scattering approximations. Example calculations are performed for a model of the head consisting of a skull layer, cerebrospinal fluid layer, and cortex layer and a model of a port wine stain consisting of epidermis, dermis, and vascular malformation layers. Results obtained with the PN-method are shown to agree with Monte Carlo simulation but are obtained in a fraction of the time needed for accurate Monte Carlo results.
Effects of Ganoderma Lucidum and Krestin on Subset T-cell in Spleen of γ-irradiated Mice (1995)

Effects of Ganoderma lucidum (Gl) and Krestin (PSK) extracts on spleen, thymus and splenocytes in gamma-irradiated mice were investigated in this study. ICR strain male mice were divided into five groups. Group A was the normal control. Group B, the experimental control, was treated with Gl. Group C, the radiation treatment control, was treated with whole body exposure to 4 Gy gamma-irradiation (RT). Group D was treated with RT and Gl. Group E was treated with RT and PSK. The dosage of Gl was 400 mg/day/kg body weight and PSK was 500 mg/day/kg body weight. Our results indicated that the relative thymus weight in groups D and E were higher than group C on day 28 after gamma-irradiation. Group D was the highest in all the experimental groups. CD4 and CD8 splenocytes in group D were higher than group C on days 7 and 28. Gl was better than PSK in repairing the damage of subset T-cells in the spleen of gamma-irradiated mice.