gebhart/patrepeval huggingface dataset:
A Reader Anti-collision MAC Protocol for Dense Reader RFID System (2009)

In dense reader RFID system, a number of readers in the same interrogation area want to access the channel at the same time suffer from reader collision problem. In this paper, we propose a distributed reader anti-collision MAC protocol (RAMP) for dense reader environment. We extended the pulse protocol by adding multiple data channels and the channel hopping algorithm. The channel hopping algorithm helps to decide whether to hop for new channel or wait in the same channel. Also, channel utilization probability based random backoff mitigates the collision possibility in the control channel. Simulation result shows that our protocol mitigates reader's collision, hence decreases waiting time significantly than the existing RFID MAC protocol.
Abstract 3953: C-Kit and Mitf signaling: Novel involvement of the PI3K/Akt and p38 pathways (2010)

Abstract The development of melanocyte from melanoblast is regulated by the tyrosine kinase receptor c-Kit and the basic-helix-loop-heliz-leucine zipper transcription factor Mitf. It is established that Mitf activity is controlled by c-Kit activation and subsequent phosphorylation of the Erk/Mapk pathway. Serine phosphorylation (activation) of Mitf not only leads to upregulation of Mitf target gene expression but also ubiquitin dependent proteosomal degradation of Mitf. There is little knowledge surrounding the dysregulation between c-Kit and Mitf signaling that is often found in melanocyte progression to melanoma. The aim of our study is, therefore, to identify the signal transduction pathways involved in c-Kit mediated regulation of Mitf. In our study, we found c-Kit tyrosine phosphorylation sites and novel signaling pathways involved in the regulation of Mitf. Phosphorylation of c-Kit at Tyr721 has been shown to activate the PI3K pathway and Tyr568 and Tyr568/570 are responsible for Src kinase mediated activation of Erk/Mapk pathway. We demonstrate that Y721F, Y568F and Y568/570F mutation of c-Kit prevented Mitf mobility shift, indicating that these tyrosine phosphorylation sites are involved in Mitf regulation. Further, we observe that treatment of c-Kit and Mitf transfected HEK293T cells with LY294002 (PI3K inhib.), Akt IV (Akt inhib.), SU6656 (Src kinase inhib.), SB203580 (p38 inhib.) or U0126 (Mek inhib.) prevented c-Kit mediated Mitf mobility shift. Similar results were also observed in the murine melanocyte, Melan- A cell line where Mitf and c-Kit are endogenously expressed. In order to further verify c-Kit's role as Mitf regulator, we examined tyrosinase (downstream target of Mitf) promoter activity using a luciferase reporter construct. Ligand stimulation of c-Kit increased the Mitf target promoter activity. In conclusion, for the first time, we demonstrate that the signal transduction between c-Kit and Mitf is dependent on, 1) c-Kit Tyr721/PI3K/Akt pathway, 2) p38 pathway and 3) c-Kit Tyr568 or Tyr568/570 / Src kinase mediated Erk pathway. C-Kit activation leading to downstream were also shown to promote the transcriptional activity of Mitf. Our results reveal novel mechanisms by which c-Kit signaling regulates Mitf, with implication for understanding of both melanocyte development and melanoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3953.
Hemodynamic Changes Following Experimental Production and Correction of Acute Mitral Regurgitation with an Adjustable Ring Prosthesis (1988)

The hemodynamic effects of acute mitral regurgitation (MR) were investigated using a newly designed adjustable mitral ring prosthesis with remote control mechanism, implanted in mongrel dogs. The prosthesis allows to dilate the mitral annulus from outside the beating heart, and to create reversible MR of any desired degree without injuring the mitral valve apparatus. Dilatation of the mitral annulus by 25% of its circumference led to MR of angiographic grade 3+. Left ventricular systolic pressure (LVSP) dropped by 20%; dp/dtmax of the left ventricle by 16% and forward cardiac output (CO) by 31%. Left ventricular enddiastolic pressure (LVEDP) rose by 41%. The amplitude of the v-wave of the left atrium (LA) doubled, and mean LA pressure rose by 33%. If correction was carried out within one hour, then all parameters returned to normal. Maintaining the same degree of annular dilatation for two hours led to a further marked deterioration of the hemodynamics. LVSP dropped by 40%, dp/dtmax by 32% and CO by 58%. LVEDP rose by 160%. The amplitude of the v-wave of the LA increased by 300% and mean LA pressure doubled. MR, as determined by contrast 2-dimensional echocardiography (2DCE) intraoperatively, further increased in severity during the second hour, though annular size remained unchanged. In contrast to correction after one hour, correction carried out after two hours led to a slow, and, even after 12 hours, incomplete recovery. Electron microscope studies suggest papillary muscle dysfunction as a major cause of these late and partially irreversible changes.
Learning Koopman Representations for Hybrid Systems (2020)

The Koopman operator lifts nonlinear dynamical systems into a functional space of observables, where the dynamics are linear. In this paper, we provide three different Koopman representations for hybrid systems. The first is specific to switched systems, and the second and third preserve the original hybrid dynamics while eliminating the discrete state variables; the second approach is straightforward, and we provide conditions under which the transformation associated with the third holds. Eliminating discrete state variables provides computational benefits when using data-driven methods to learn the Koopman operator and its observables. Following this, we use deep learning to implement each representation on two test cases, discuss the challenges associated with those implementations, and propose areas of future work.
Self‐assembled GaN nanostructures by dry etching and their optical properties (2012)

Abstract The influence of process parameters and template characteristics on the morphology and optical properties of self‐assembled nanostructures produced by dry etching from GaN/sapphire templates was investigated. It was found that the chemical component in the etching gas–chlorine supports the formation of nanostructures and that a minimum amount of RF and ICP power (i.e., energy) is necessary. Additionally the crystalline imperfection and the doping concentration of the template greatly affect the nanostructure morphology. All nanostructures exhibit higher luminescence intensity than the templates they are fabricated from and exhibit a red‐shift of the luminescence with respect to the epilayer. The results indicate effective strain relaxation as well as more efficient absorption of the incoming photons the smaller the nanostructures become.
A modified random oligonucleotide-based combination therapy for adjuvant treatment of pancreatic ductal adenocarcinoma (2006)

Anti-cancer therapy in pancreatic ductal adenocarcinoma (PDAC) is mostly based on surgical removal or palliative therapy using antimetabolites, like 5'-fluorouracil or gemcitabine. Adjuvant treatment using these chemotherapeutics has recently proven a beneficial concept, though general survival rates are still poor. Most recently, combination therapy of gemcitabine with other targeted drugs was evaluated in clinical trials. We present here a study performed in a mouse orthotopic xenotransplant model of PDAC, using an oligo-nucleotide-based approach. We have shown previously that antisense oligonucleotides against p53 reduce the weight of orthotopic pancreatic tumours in immune-deficient mice. We further characterised terminal modifications of phosphorothioate oligonucleotides in vitro and found a random, unrelated control sequence carrying a D,L-alpha-tocopherol modification at the 5' and 3' ends to be most efficient in induction of cell death in PancTu-1 cells. Modified random oligonucleotide (MRON) were thus further tested in vivo. MRON showed a reduction of tumour weight in established primary orthotopic tumours in SCID/bg mice. In a surgically adapted pre-clinical model, where primary tumours were resected and animals received adjuvant treatment, MRON was very efficient in suppression of relapse and metastasis, when combined with gemcitabine. While the exact molecular mechanism of MRON activity still needs to be elucidated, the compound showed a remarkable preference for uptake into tumour cells in vivo.
Transcriptional activation of the pathway‐specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor (2005)

The Streptomyces produce a plethora of secondary metabolites including antibiotics and undergo a complex developmental cycle. As a means of establishing the pathways that regulate secondary metabolite production by this important bacterial genus, the model species Streptomyces coelicolor and its relatives have been the subject of several genetic screens. However, despite the identification and characterization of numerous genes that affect antibiotic production, there is still no overall understanding of the network that integrates the various environmental and growth signals to bring about changes in the expression of biosynthetic genes. To establish new links, we are taking a biochemical approach to identify transcription factors that regulate antibiotic production in S. coelicolor. Here we describe the identification and characterization of a transcription factor, designated AtrA, that regulates transcription of actII-ORF4, the pathway-specific activator of the actinorhodin biosynthetic gene cluster in S. coelicolor. Disruption of the corresponding atrA gene, which is not associated with any antibiotic gene cluster, reduced the production of actinorhodin, but had no detectable effect on the production of undecylprodigiosin or the calcium-dependent antibiotic. These results indicate that atrA has specificity with regard to the biosynthetic genes it influences. An orthologue of atrA is present in the genome of Streptomyces avermitilis, the only other streptomycete for which there is a publicly available complete sequence. We also show that S. coelicolor AtrA can bind in vitro to the promoter of strR, a transcriptional activator unrelated to actII-ORF4 that is the final regulator of streptomycin production in Streptomyces griseus. These findings provide further evidence that the path leading to the expression of pathway-specific activators of antibiotic biosynthesis genes in disparate Streptomyces may share evolutionarily conserved components in at least some cases, even though the final activators are not related, and suggests that the regulation of streptomycin production, which serves an important paradigm, may be more complex than represented by current models.
Avaliação da precocidade e de sólidos solúveis em acessos de melancia do Banco Ativo de Germoplasma de Cucurbitaceas do Nordeste brasileiro. (2011)

O objetivo deste trabalho foi avaliar a precocidade e os sólidos solúveis de acessos de melancia do Banco Ativo de Germoplasma de Cucurbitáceas do Nordeste brasileiro. O experimento foi conduzido na Embrapa Semiárido, Petrolina, PE, onde foram semeados 31 acessos de melancia em bandejas de poliestireno, contendo substrato comercial para hortaliças. Após 12 dias, foi realizado o transplantio para o campo, no espaçamento de 3,0 mx 0,8 m, utilizando a irrigação por gotejamento. O delineamento utilizado foi inteiramente casualizado com 31 tratamentos e três repetições Foi avaliado o número de dias para o surgimento da primeira flor masculina e feminina de cada planta e os teores de sólidos solúveis (ºBrix). As médias foram comparadas pelo teste de Scott- Knott a 5% de probabilidade. Os acessos BGCIA 525 e BGCIA 554 (28,2 dias) foram os mais precoces para a emissão das flores masculinas e o BGCIA 554 (33,2 dias) em relação ao aparecimento das flores femininas. O BGCIA 299 foi o mais tardio. Os sólidos solúveis variaram de 5,3 oBrix (BGCIA 51) a 8,96 oBrix (BGCIA 471). Os acessos apresentaram variabilidade genética em relação à precocidade, que deve ser considerada na multiplicação de acessos e nos trabalhos de melhoramento genético da melancia.
The regulation of mineral absorption in the gastrointestinal tract (1999)

The absorption of metal ions in the mammalian single-stomached gut is fortunately highly selective, and both luminal and tissue regulation occur. Initially, assimilation of metal ions in an available form is facilitated by the intestinal secretions, chiefly soluble mucus (mucin) that retards hydrolysis of ions such as Cu, Fe and Zn. Metal ions then bind and traverse the mucosally-adherent mucus layer with an efficiency M+ > M2+ > M3+. At the mucosa Fe3+ is probably uniquely reduced to Fe2+, and all divalent cations (including Fe2+) are transported by a membrane protein (such as divalent cation transporter 1) into the cell. This minimizes absorption of toxic trivalent metals (e.g. Al3+). Intracellular metal-binding molecules (such as mobilferrin) may be present at the intracellular side of the apical membrane, anchored to a transmembrane protein such as an integrin complex. This mobilferrin would receive the metal ion from divalent cation transporter 1 and, with part of the integrin molecule, transport the metal to the cytosol for safe sequestration in a larger complex such as ferritin or 'paraferritin'. beta 2-Microglobulin and HFE (previously termed human leucocyte antigen H) may be involved in stabilizing metal mobilferrin-integrin to form this latter complex. Finally, a systemic metal-binding protein such as transferrin may enter the antiluminal (basolateral) side of the cell for binding of the sequestered metal ion and delivery to the circulation. Regulatory proteins, such as HFE, may determine the degree of ion transport from intestinal cells to the circulation. Gradients in pH and perhaps pCa or even pNa could allow the switching of ions between the different transporters throughout this mechanism.
Enhancement of superconductivity mediated by antiferromagnetic squeezed magnons (2019)

Spin states in quantum antiferromagnets are coherent superpositions of ``up'' and ``down'' spin flips. The average spin on each sublattice associated with an antiferromagnetic magnon is, therefore, much larger than its unit net spin. Here, the authors demonstrate that proximity, which couples the electronic states in a metal asymmetrically to the two sublattices of an antiferromagnet, enhances the strength of the magnon-induced electronic interactions in the metal, and dramatically increases the transition temperature for the resulting magnon-mediated superconductivity.
ADVANCED STUDY OF SECONDARY FLOWSTRUCTURES IN AHIGHLY LOADED COMPRESSOR CASCADE (2015)

The current paper deals with a detailed experimental and numerical investigation of the
secondary flow structures in the corner region between blade and endwall in a highly loaded
compressor cascade, with the objective to provide extensive validation data and performing a
first comparison with numerical results. The used cascade has been designed and optimized
specifically for use at low Reynolds number conditions, as can be found at high altitudes. The
study was divided into an experimental and a numerical part. The experimental part of the
investigation was performed in the transonic cascade wind tunnel of DLR in Cologne at a
Mach number of 0.6 and Reynolds number of 9.0x105. Wake measurements with a 5-hole
probe at four distances behind the cascade trailing edge were carried out, in order to obtain
measurement data of the loss distribution, comparable to the numerical results. Furthermore,
oil streak patterns on the endwall and blade surface were conducted. Additionally, tomographic
PIV (tomo-PIV) and conventional stereo PIV (SPIV) are utilized, in order to assess the quality
of CFD prediction of the flow structure in the corner region.
The numerical investigation of the cascade flow was performed by means of the turbomachinery
CFD code TRACE, which is an in-house developed code of the DLR Institute of Propulsion
Technology. The focus was on the detailed description of the secondary flow close to the
corner region and on the determination of the loss distribution in the wake behind the cascade.
Furthermore, the influence of the boundary layer transition on the cascade flow was considered
by the usage of a transition model.
In the paper a detailed comparison between the experimental and the nurmerical results is
given. It is shown, that the experimental extension of the corner separation on the cascade
surfaces and the development of the loss distribution behind the cascade is well reflected by the
CFD results, but there are differences in the loss intensity
Wrist pulse signal classification for inflammation of appendix, pancreas, and duodenum (2014)

Wrist pulse signal is believed to contain critical information of the patients' health condition. This project aims to analyze the time series wrist pulse signals in order to distinguish patients suffering from various symptoms with healthy people. In this paper, the four inflammation symptoms tackled in this project are Appendicitis (A), Acute Appendicitis (AA), Pancreatitis (P) and Duodenal Bulb Ulcer (DBU). Moreover, studying the characteristic of blood flow in arteries and cardiac cycle is crucial for the sake of selecting features from the wrist pulse signals. The defined Doppler parameters in the wrist pulse signal are defined as the disease sensitive features. Furthermore, the features extracted are considered as the parameters for training the Support Vector Machine (SVM) classifier. The classification accuracy can reach over 88% in distinguishing patients with healthy persons from Acute Appendicitis and up to 98% from Pancreatitis. These results indicate the methodology proposed in this project can provide an advanced idea for enhancing the research of wrist pulse signal analysis.
The embedded tumour: host physiology is important for the evaluation of tumour growth (2003)

The growth potential of a tumour can significantly depend on host features such as age, cell proliferation rates and caloric intake. Although this is widely known, existing mathematical models for tumour growth do not account for it. We therefore developed a new model for tumour growth, starting from a mathematical framework that describes the host's physiology. The resulting tumour-in-host model allowed us to study the implications of various specific interactions between the energetics of tumour and host. The model accounts for the influence of both age and feeding regimen of the host organism on the behaviour of a tumour. Concerning the effects of a tumour on its host, it explains why tumour-mediated body-weight loss is often more dramatic than expected from the energy demands of the tumour. We also show how the model can be applied to study enhanced body-weight loss in presence of cachectic factors. Our tumour-in-host model thus appears a proper tool to unite a wide range of phenomena in tumour-host interactions.
Psychological Aspects of the Israeli–Palestinian Conflict: A Systematic Review (2015)

Despite ongoing local and international peace efforts, the Jews, Arabs, and other residents of Israel and the Palestinian territories (i.e., the West Bank and Gaza) have endured decades of political, social, and physical upheaval, with periodic eruptions of violence. It has been theorized that the psychological impact of the Israeli-Palestinian conflict extends beyond the bounds of psychiatric disorders such as posttraumatic stress disorder (PTSD). Exposure to the ongoing conflict may lead to changes in the way Israelis and Palestinians think, feel, and act; while these changes may not meet the thresholds of PTSD or depression, they nonetheless could have a strong public health impact. It is unclear whether existing studies have found associations between exposure to the conflict and nonclinical psychological outcomes. We conducted a systematic review to synthesize the empirical research on the Israeli-Palestinian conflict and its psychological consequences. As a whole, the body of literature we reviewed suggests that exposure to regional political conflict and violence may have detrimental effects on psychological well-being and that these effects likely extend beyond the psychiatric disorders and symptoms most commonly studied. We found evidence that exposure to the conflict informs not only the way Israelis and Palestinians think, feel, and act but also their attitudes toward different religious and ethnic groups and their degree of support for peace or war. We also found that Palestinians may be at particularly high risk of experiencing psychological distress as a result of the conflict, though more research is needed to determine the extent to which this is due to socioeconomic stress. Our review suggests the need for more studies on the nonclinical psychological aspects of the Israeli-Palestinian conflict as well as for longitudinal studies on the impact of the conflict on both Israelis and Palestinians.
Dnase1l3 deficiency in lupus-prone MRL and NZB/W F1 mice (2003)

Loss of deoxyribonuclease I (Dnase1) function is associated with systemic lupus erythematosus (SLE) in humans and mice; however, no coding mutations in Dnase1 are found in polygenic murine models. Instead, both MRL-lpr strains and NZB/W F1 hybrids are homozygous for T89I missense in the macrophage-DNASE, desoxyribonuclease I-like 3 (Dnase1l3). By in vitro expression studies, this substitution decreases this enzyme's nuclease activity against free DNA by only approximately twofold; however, the mutation has a greater effect on the capacity of media conditioned with Dnase1l3 to confer a barrier to liposomal gene transfection to HeLa cells. The 89I substitution decreases the Dnase1l3 barrier function in vitro by eightfold (P < 0.01). In splenocytes and BM-derived macrophages of SLE mice, while cellular Dnase1l3 levels are induced relative to C57BL/6 (control) mice, levels of FD-nuclease activity are similar. Finally, media conditioned by MRL and NZB/W F1 macrophages, relative to control, contains a weak interferon-gamma (IFN-gamma) inducible Dnase1l3-associated barrier to transfection. This barrier function is hypothesized to reflect the inability of SLE mice to degrade membrane-enveloped DNA-associated antigens, such as apoptotic bodies, which are predicted to stimulate the characteristic autoimmunity of SLE. Our results for these two generally independent models strongly suggest that Dnase1l3 deficiency increases the susceptibility of these mice to polygenic SLE.