gebhart/patrepeval huggingface dataset:
Power spectral and Poincaré plot characteristics in sinus node dysfunction (2003)

A salient feature of the normal sinus node activity is its prominent beat-to-beat variability, which shows self-similarity on different time scales (fractal dynamics). However, in patients with sinus node dysfunction, short-term time sinus cycles show exaggerated variability, the characteristics of which have not been analyzed. Therefore, Poincaré plots and power spectral analysis were applied to short-term variations of sinus cycles in 30 patients with and 30 patients without sinus node disease. Three patterns of behavior were observed in sick sinus patients: type 1, completely normal (n = 3); type 2, randomlike pattern in the Poincaré plots with "white noise" power spectra (n = 9); and type 3, a transitional pattern, characterized by remnants of normal behavior mixed with scattered points (n = 18). In control subjects, only type 1 (n = 27) and type 3 (n = 3) patterns were observed, P < 0.0001. The power spectral changes in sinus node dysfunction are thus characterized by a loss of the inverse power law relationship, which both has implications for heart rate variability analysis and might offer a new diagnostic approach.
Test Methodologies and Field Verification of Corrosion Inhibitors to Address under Deposit Corrosion in Oil and Gas Production Systems (2005)

Abstract A research program, suggested by an oil producer was initiated to develop and test corrosion inhibitors having good performance in pipelines suffering from corrosion associated with deposited solids. The program comprised the development of candidate DSTI’s (Deposited Solids Tolerant Inhibitors) using column adsorption tests, which were then subjected to an inhibition performance test, also had to be developed. The oil producer defined its needs and offered pipelines for field verification. A specific inhibitor (designated C) has been identified as a good DSTI, having superior performance over the incumbent inhibitor in the oil producer's sweet pipelines system. The laboratory inhibition performance test developed enables the simultaneous testing of inhibitors for their performance in regular (non solids covered) systems and underneath solids. A field verification program has been scheduled to obtain the final confirmation before full deployment of Inhibitor C in the oil producer’s solids bearing lines. To that end the Field Corrosivity Toolbox has been modified to enable the performance testing of DSTI’s underneath solids.
Safety of, and biological and functional response to, a novel metallic implant for the management of focal full‐thickness cartilage defects: Preliminary assessment in an animal model out to 1 year (2006)

Focal full-thickness cartilage lesions of the human medial femoral condyle (MFC) can cause pain and functional impairment. Affected middle-aged patients respond unpredictably to existing treatments and knee arthroplasty may be required, prompting risk of revision. This study assesses the safety of, and biological and functional response to, a metallic resurfacing implant which may delay or obviate the need for traditional arthroplasty. The anatomic contour of the surgically exposed MFC of six adult goats was digitally mapped and an 11 mm diameter full-thickness osteochondral defect was created. An anchor-based Co-Cr resurfacing implant, matching the mapped articular contour, was implanted. Each goat's contralateral unoperated femorotibial joint was used as a control. Postoperative outcome was assessed by lameness examination, radiography, arthroscopy, synoviocentesis, necropsy, and histology up to 26 (n = 3) or 52 (n = 3) weeks. By postoperative week (POW) 4, goats demonstrated normal range of motion, no joint effusion, and only mild lameness in the operated limb. By POW 26 the animals were sound with only occasional very mild lameness. Arthroscopy at POW 14 revealed moderate synovial inflammation and a chondral membrane extending centrally across the implant surface. Radiographs at POWs 14 to 52 implied implant stability in the operated joints, as well as subchondral bone remodeling and mild exostosis formation in the operated and contralateral unoperated joints of some goats. By POW 26, histology revealed new trabecular bone abutting the implant. At POWs 26 and 52 MFC cartilage was metachromatic and intact in the operated and unoperated femorotibial joints. Proximal tibiae of some operated and unoperated limbs demonstrated limited subchondral bone remodeling and foci of articular cartilage fibrillation and thinning. The chondral membrane crossing the prosthesis possessed a metachromatic matrix containing singular and clustered chondrocytes. Our data imply the safety, biocompatibility, and functionality of the implant. Focal articular damage was documented in the operated joints at POWs 26 and 52, but lesions were much reduced over those previously reported in untreated defects. Expanded animal or preclinical human studies are justified.
Finding the Number of Clusters in Unlabeled Datasets using Extended Dark Block Extraction (2010)

Clustering analysis is the problem of partitioning a set of objects O = {o1 on} into c self-similar subsets based on available data. In general, clustering of unlabeled data poses three major problems: 1) assessing cluster tendency, i.e., how many clusters to seek? 2) Partitioning the data into c meaningful groups, and 3) validating the c clusters that are discovered. We address the first problem, i.e., determining the number of clusters c prior to clustering. Many clustering algorithms require number of clusters as an input parameter, so the quality of the clusters mainly depends on this value. Most methods are post clustering measures of cluster validity i.e., they attempt to choose the best partition from a set of alternative partitions.
Activation of glucose-6-phosphatase in intact hepatic microsomes (1990)

Correspondence| September 15 1990 Activation of glucose-6-phosphatase in intact hepatic microsomes I D Waddell; I D Waddell Search for other works by this author on: This Site PubMed Google Scholar A Burchell A Burchell Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1990) 270 (3): 839–840. https://doi.org/10.1042/bj2700839 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation I D Waddell, A Burchell; Activation of glucose-6-phosphatase in intact hepatic microsomes. Biochem J 15 September 1990; 270 (3): 839–840. doi: https://doi.org/10.1042/bj2700839 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1990 London: The Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Compact Wideband Low-Profile Single- and Dual-Polarized Dielectric Resonator Antennas Using Dielectric and Air Vias (2021)

A low-profile DRA employing dielectric and air vias is investigated. The structure is realized utilizing PCB technology only. The dielectric vias are formed by filling up cylindrical holes with barium strontium titanate (BST) nanoparticles with a dielectric constant of 20 and a loss tangent of 0.023. Using this technique, the antenna can be made compact, without the need for using external, high dielectric-constant materials that are unavailable for standard PCB manufacturing. By skillfully arranging air vias inside the DRA, the resonant frequencies of different modes can be controlled, and a wide impedance bandwidth with stable radiation performance can be achieved. The whole antenna structure can be manufactured using standard PCB materials and manufacturing technologies. Our prototype achieves a wide measured impedance bandwidth of 47.5% and a maximum measured gain of 6.84 dBi. Furthermore, a small antenna footprint of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$0.616\times 0.616\,\,\lambda _{0}^{2}$ </tex-math></inline-formula> with a low profile of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$0.095~\lambda _{0}$ </tex-math></inline-formula> is achieved, where <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\lambda _{0}$ </tex-math></inline-formula> is the wavelength in the air at the center frequency. A dual-polarized antenna is investigated using this design technique. It achieves an overlapping bandwidth of 34.88% of its two ports with isolation of higher than 25.76 dB and stable radiation performance across the passband.
EXPERIMANTAL STUDY ON RESISTANCE PROPERTIES OF FLAP-GATE BREAKWATER AGAINST TSUNAMI (2014)

フラップゲート式防波堤は，通常海底に倒伏し，運用時には浮力を利用して浮上させて港口を閉鎖する津波防御施設である．東北地方太平洋沖地震津波では多くの海岸構造物が被災したことから，これからの津波防御施設には，設計条件を超過する津波に対しても直ちに倒壊することなく，粘り強く抵抗することが求められる．本研究では，支持地盤からの反力を計測するための受圧機構を設けた1/40縮尺の試験体を用いて，造波水路内における模擬津波実験を実施して，フラップゲート式防波堤の津波に対する抵抗力について検討した．試験体の支持マウンド内への埋設深さや，作用させる模擬津波の条件を変えた一連の実験を通して，試験体を一定深さ以上埋設して設置することで，津波に対する抵抗力が顕著に増大することを確認し，揚圧力の作用状況についても把握した．また，こうした実験結果を簡易な机上計算によって検証し，良く整合した．
A Virtual-Queue-Based Algorithm for Constrained Online Convex Optimization With Applications to Data Center Resource Allocation (2018)

In this paper, online convex optimization (OCO) problems with time-varying objective and constraint functions are studied from the perspective of an agent who takes actions in real time. Information about the current objective and constraint functions is revealed only after the corresponding action is already chosen. Inspired by a fast converging algorithm for time-invariant optimization in the very recent work [1], we develop a novel online algorithm based on virtual queues for constrained OCO. Optimal points of the dynamic optimization problems with full knowledge of the current objective and constraint functions are used as a dynamic benchmark sequence. Upper bounds on the regrets with respect to the dynamic benchmark and the constraint violations are derived for the presented algorithm in terms of the temporal variations of the underlying dynamic optimization problems. It is observed that the proposed algorithm possesses sublinear regret and sublinear constraint violations, as long as the temporal variations of the optimization problems are sublinear, i.e., the objective and constraint functions do not vary too drastically across time. The performance bounds of the proposed algorithm are superior to those of the state-of-the-art OCO method in most scenarios. Besides, different from the saddle point methods widely used in constrained OCO, the stepsize of the proposed algorithm does not rely on the total time horizon, which may be unknown in practice. Finally, the algorithm is applied to a dynamic resource allocation problem in data center networks. Numerical experiments are conducted to corroborate the merit of the developed algorithm and its advantage over the state-of-the-art.
Antioxidant network expression abrogates oxidative posttranslational modifications in mice (2011)

Antioxidant enzymatic pathways form a critical network that detoxifies ROS in response to myocardial stress or injury. Genetic alteration of the expression levels of individual enzymes has yielded mixed results with regard to attenuating in vivo myocardial ischemia-reperfusion injury, an extreme oxidative stress. We hypothesized that overexpression of an antioxidant network (AON) composed of SOD1, SOD3, and glutathione peroxidase (GSHPx)-1 would reduce myocardial ischemia-reperfusion injury by limiting ROS-mediated lipid peroxidation and oxidative posttranslational modification (OPTM) of proteins. Both ex vivo and in vivo myocardial ischemia models were used to evaluate the effect of AON expression. After ischemia-reperfusion injury, infarct size was significantly reduced both ex vivo and in vivo, ROS formation, measured by dihydroethidium staining, was markedly decreased, ROS-mediated lipid peroxidation, measured by malondialdehyde production, was significantly limited, and OPTM of total myocardial proteins, including fatty acid-binding protein and sarco(endo)plasmic reticulum Ca(²+)-ATPase (SERCA)2a, was markedly reduced in AON mice, which overexpress SOD1, SOD3, and GSHPx-1, compared with wild-type mice. These data demonstrate that concomitant SOD1, SOD3, and GSHPX-1 expression confers marked protection against myocardial ischemia-reperfusion injury, reducing ROS, ROS-mediated lipid peroxidation, and OPTM of critical cardiac proteins, including cardiac fatty acid-binding protein and SERCA2a.
SRAM SER in 90, 130 and 180 nm bulk and SOI technologies (2004)

We investigate the soft error rate (SER) of bulk and SOI SRAMs at the 90, 130 and 180 nm technology nodes. We use accelerated testing and Monte Carlo modeling to determine SER sensitivity to different radiation sources; we can therefore predict the product SER based on the radiation flux. Lifetests performed underground, near sea level, and at 10,000 feet confirm the predicted SER levels.
On a fixed duration pursuit differential game with geometric and integral constraints (2014)

In this paper we investigate a differential game in which countably many dynamical objects pursue a single one. All the players perform simple motions. The duration of the game is fixed. The controls of a group of pursuers are subject to geometric constraints and the controls of the other pursuers and the evader are subject to integral constraints. The payoff of the game is the distance between the evader and the closest pursuer when the game is terminated. We construct optimal strategies for players and find the value of the game.
Ultradeep hydrodesulfurization of fuel over superior NiMoS phases constructed by a novel Ni(MoS4)2(C13H30N)2 precursor (2020)

Ni(MoS<sub>4</sub>)<sub>2</sub>(C<sub>13</sub>H<sub>30</sub>N)<sub>2</sub> was synthesized and adopted for preparing a NiMoS/γ-Al<sub>2</sub>O<sub>3</sub> hydrodesulfurization catalyst, and the as-prepared catalyst exhibits superior 4,6-dimethyldibenzothiophene hydrodesulfurization activity.
An automated framework for efficiently designing deep convolutional neural networks in genomics (2020)

Abstract Convolutional neural networks (CNNs) have become a standard for analysis of biological sequences. Tuning of network architectures is essential for CNN’s performance, yet it requires substantial knowledge of machine learning and commitment of time and effort. This process thus imposes a major barrier to broad and effective application of modern deep learning in genomics. Here, we present AMBER, a fully automated framework to efficiently design and apply CNNs for genomic sequences. AMBER designs optimal models for user-specified biological questions through the state-of-the-art Neural Architecture Search (NAS). We applied AMBER to the task of modelling genomic regulatory features and demonstrated that the predictions of the AMBER-designed model are significantly more accurate than the equivalent baseline non-NAS models and match or even exceed published expert-designed models. Interpretation of AMBER architecture search revealed its design principles of utilizing the full space of computational operations for accurately modelling genomic sequences. Furthermore, we illustrated the use of AMBER to accurately discover functional genomic variants in allele-specific binding and disease heritability enrichment. AMBER provides an efficient automated method for designing accurate deep learning models in genomics.
Hand X-ray examination in two planes is not required for radiographic assessment of hand osteoarthritis (2020)

This is the first study to confirm that additional radiographic planes, oblique/lateral views, are not necessary in the diagnostic process in HOA in daily clinical practice. Nevertheless, the presence of dvOPs reflect more severe joint damage and is associated with radiographic progression in HOA; hence, oblique/lateral views could be a useful tool for academic purposes.
Purification and characterization of eucaryotic alanine racemase acting as key enzyme in cyclosporin biosynthesis. (1994)

A specific alanine racemase, which is a key enzyme in the biosynthesis of the undecapeptide cyclosporin A, was purified to electrophoretic homogeneity from the fungus Tolypocladium niveum. This is the first enzyme of this kind isolated from a eucaryotic organism. The enzyme catalyzes the reversible racemization of alanine and requires pyridoxal phosphate as the exclusive cofactor. Km values for L- and D-alanine were found to be 38 and 2 mM, respectively. Maximal reaction velocity was observed at 42 degrees C and pH 8.8 for the L to D direction. Molecular mass determinations of the denatured enzyme by SDS-polyacrylamide gel electrophoresis gave a value of 37 kDa, whereas gel filtration calibration studies yielded a value between 120 and 150 kDa, indicating an oligomeric native structure.
Image Transformation based Features for the Visual Discrimination of Prominent and Non-ProminentWords (2012)

This paper investigates how visual information extracted from a speaker’s mouth region can be used to discriminate prominent from non-prominent words. The analysis relies on a database where users interacted in a small game with a computer in a Wizard of Oz experiment. Users were instructed to correct recognition errors of the system. This was expected to render the corrected word highly prominent. Audio-visual recordings with a distant microphone and without visual markers were made. As acoustic features relative energy and fundamental frequency were calculated. From the visual channel image transformation based features from the mouth region were extracted. As image transformations FFT, DCT and PCA with a varying number of coefficients are compared in this paper. Thereby the performance of the visual features by themselves or in combination with the acoustic features is investigated. The comparison is based on the classification with a Support Vector Machine (SVM). The results show that all three image transformations yield a performance of approx. 65% in this binary classification task. Furthermore, the information extracted from the visual channel is complementary to the acoustic information. The combination of both modalities significantly improves performance up to approx. 80%. 1
Characterizing Defective Configuration Scripts Used for Continuous Deployment (2018)

In software engineering, validation and verification (V&V) resources are limited and characterization of defective software source files can help in efficiently allocating V&V resources. Similar to software source files, defects occur in the scripts used to automatically manage configurations and software deployment infrastructure, often known as infrastructure as code (IaC) scripts. Defects in IaC scripts can have dire consequences, for example, creating large-scale system outages. Identifying the characteristics of defective IaC scripts can help in mitigating these defects by allocating V&V efforts efficiently based upon these characteristics. The objective of this paper is to help software practitioners to prioritize validation and verification efforts for infrastructure as code (IaC) scripts by identifying the characteristics of defective IaC scripts. Researchers have previously extracted text features to characterize defective software source files written in general purpose programming languages. We investigate if text features can be used to identify properties that characterize defective IaC scripts. We use two text mining techniques to extract text features from IaC scripts: the bag-of-words technique, and the term frequency-inverse document frequency (TF-IDF) technique. Using the extracted features and applying grounded theory, we characterize defective IaC scripts. We also use the text features to build defect prediction models with tuned statistical learners. We mine open source repositories from Mozilla, Openstack, and Wikimedia Commons, to construct three case studies and evaluate our methodology. We identify three properties that characterize defective IaC scripts: filesystem operations, infrastructure provisioning, and managing user accounts. Using the bag-of-word technique, we observe a median F-Measure of 0.74, 0.71, and 0.73, respectively, for Mozilla, Openstack, and Wikimedia Commons. Using the TF-IDF technique, we observe a median F-Measure of 0.72, 0.74, and 0.70, respectively, for Mozilla, Openstack, and Wikimedia Commons.
A Model for the Simulation of the CnEm Nonionic Surfactant Family Derived from Recent Experimental Results (2020)

&lt;div&gt;&lt;div&gt;&lt;div&gt;&lt;p&gt;Using a comprehensive set of recently published experimental results for training and validation, we have developed computational models appropriate for simulations of aqueous solutions of poly(ethylene oxide) alkyl ethers, an important class of micelle- forming nonionic surfactants, usually denoted CnEm. These models are suitable for use in simulations that employ a moderate amount of coarse graining and especially for dissipative particle dynamics (DPD), which we adopt in this work.&lt;/p&gt;&lt;p&gt;&lt;br&gt;&lt;/p&gt;&lt;p&gt;The experimental data used for training and validation were reported earlier and produced in our laboratory using dynamic light scattering (DLS) measurements per- formed on twelve members of the CnEm compound family yielding micelle size dis- tribution functions and mass weighted mean aggregation numbers at each of several surfactant concentrations. The range of compounds and quality of the experimental results were designed to support the development of computational models. An es- sential feature of this work is that all simulation results were analysed in a way that is consistent with the experimental data. Proper account is taken of the fact that a broad distribution of micelle sizes exists, so mass weighted averages (rather than num- ber weighted averages) over this distribution are required for the proper comparison of simulation and experimental results.&lt;/p&gt;&lt;p&gt;&lt;br&gt;&lt;/p&gt;&lt;p&gt;The resulting DPD force field reproduces several important trends seen in the exper- imental critical micelle concentrations and mass averaged mean aggregation numbers with respect to surfactant characteristics and concentration. We feel it can be used to investigate a number of open questions regarding micelle sizes and shapes and their dependence on surfactant concentration for this important class of nonionic surfactants.&lt;/p&gt;&lt;/div&gt;&lt;/div&gt;&lt;/div&gt;
Fatal atypical T‐cell proliferation associated with Epstein–Barr virus infection (2001)

We report the case of a young Caucasian man who presented with polyneuropathy and severe, ultimately fatal, congestive heart failure in the context of a chronic active Epstein-Barr virus (EBV) infection. Post-mortem examination revealed both monoclonal and polyclonal proliferation of EBV-positive atypical T lymphocytes within different organs. Predominant infiltration of the nervous system and heart with extensive myocardial scarring accounted for the clinical symptoms. The remarkable features of this case are (i) the occurrence in a Caucasian patient, (ii) the absence of detectable immunodeficiency, and (iii) the myocardial destruction by EBV-infected monoclonal T cells.