gebhart/patrepeval huggingface dataset:
Correlation of CA-125 and RECIST evaluation in recurrent ovarian cancer (ROC): Results from a randomized phase III study of trabectedin (T) with pegylated liposomal doxorubicin (PLD) versus PLD alone (2009)

5550 Background: OVA-301, an open-label, multicenter, randomized phase III study comparing the combination of T and PLD to PLD alone in 672 ovarian cancer patients, showed significant prolongation in Progression-Free Survival (PFS) and higher Objective Response (OR) in the combination arm (T-PLD) by three separate assessments, investigator assessment (IA), independent radiology (IR) and oncology review (IO). The purpose of this analysis is to examine: 1) the impact of early changes in CA-125 over the subsequent best OR by RECIST; 2) the concordance between best OR determined by CA-125 and RECIST; 3) the value of CA-125 to predict radiological response. Methods: Tumor assessments by imaging and CA-125 were performed at baseline, and every 8 weeks during study in both arms. Radiological tumor assessment, regardless of CA-125 changes, determined the study conduct. Early CA-125 changes were those assessed at the first and second evaluation. Analyses were based on “all randomized patients.” Results: Response rate by RECIST (IR)/CA-125 was 28%/48% for T-PLD vs. 19%/33% for PLD. The association between CA-125 and RECIST response was stronger for IA relative to IR/IO, with 79% concordance for both arms, 65% overall positive predictive value (PPV) and 89% negative predictive value (NPV) for IA and 74%/75% concordance, 46%/49% PPV and 93%/92% NPV for IR/IO. Early CA-125 changes were assessed in 514 patients. Early ≥25% CA-125 decreases in the first/second evaluation occurred in 85%/95% of RECIST responders in the T-PLD arm and in 81/82% responders treated with PLD. Conclusions: The predictive value of CA-125 response was high and similar in both arms. The addition of T to PLD resulted in superior efficacy in this patient population as assessed by IA, IR and IO, with a favorable trend for CA-125 response assessment. RECIST response was preceded by a significant CA-125 decrease in a high proportion of patients. [Table: see text]
SymbiosisSketch (2018)

We present SymbiosisSketch, a hybrid sketching system that combines drawing in air (3D) and on a drawing surface (2D) to create detailed 3D designs of arbitrary scale in an augmented reality (AR) setting. SymbiosisSketch leverages the complementary affordances of 3D (immersive, unconstrained, life-sized) and 2D (precise, constrained, ergonomic) interactions for in situ 3D conceptual design. A defining aspect of our system is the ongoing creation of surfaces from unorganized collections of 3D curves. These surfaces serve a dual purpose: as 3D canvases to map strokes drawn on a 2D tablet, and as shape proxies to occlude the physical environment and hidden curves in a 3D sketch. SymbiosisSketch users draw interchangeably on a 2D tablet or in 3D within an ergonomically comfortable canonical volume, mapped to arbitrary scale in AR. Our evaluation study shows this hybrid technique to be easy to use in situ and effective in transcending the creative potential of either traditional sketching or drawing in air.
Keratinous Fiber Based Intumescent Flame Retardant with Controllable Functional Compound Loading (2018)

An intumescent flame retardant working with various combinations of acid source, blowing agent, and char former promises high performance and low toxicity. However, the research for more potent functional constituents and their best combination is still extremely important. Here we report on a novel way to use keratinous fibers as the host material for creating an effective flame retardant. A simple solution-based treatment to implant amine phosphate and phosphoric acid in the fiber through sequential monomer infiltration is found to be significantly effective for applying flame retardancy and reducing the flammability of polymeric materials. After the flame-retardant fiber modification, polypropylene (PP) shows significantly improved flame retardancy to achieve V-0 grade and >70% reduced peak heat release rate in vertical burning and cone-calorimeter tests, respectively. We expect this strategy of converting the low-grade keratinous fiber to valuable flame-retardant material to become a novel and attractive solution for achieving fire safety, value addition, and ecofriendly recycling goals at the same time.
A novel truncated nonconvex nonsmooth variational method for SAR image despeckling (2020)

Speckle reduction is a fundamental problem in coherent imaging systems. In this paper, to suppress the speckle in SAR images, we propose a novel truncated nonconvex nonsmooth model. It incorporates a truncated nonconvex regularization term and an I-divergence fidelity term. The truncated ℓpnorm (0<p<1) regularization can better recover neat edges and simultaneously prevent contrast reduction artefact. The I-divergence fidelity term is used to suppress the multiplicative noise effectively. We also propose an efficient algorithm based on variable-splitting and alternating direction method of multipliers (ADMM) method to solve the model. Compared to state-of-the-art speckle suppression methods, intensive experimental results on a variety of SAR images show the superiority of the proposed method qualitatively and quantitatively.
Improvement of the modelisation of microstrip-microslot applicator (1988)

An improved transmission-line model to characterize a microstripslot radiator for biomedical application is discussed. The applicator is a microstrip-microslot antenna which consists of a gradual transition from a classical microstrip line to a microstrip line with tuning septa; the applicator is formed by the ground plane aperture in contact with the tissue or other lossy medium. The transmission-line model of the radiating antenna is improved by using the spectral-domain approach to characterize the applicator. Numerical analysis of the propagation of the conditions is used to determine the other parameters needed for the model experimental results verifying the model are noted. The resulting transmission-line model is capable of describing the frequency behavior of the microstrip slot radiator laid on muscle.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Improvement in Driver-Vehicle System Performance by Varying Steering Gain with Vehicle Speed and Steering Angle: VGS (Variable Gear-Ratio Steering System) (1999)

&lt;div class="htmlview paragraph"&gt;Steering gear ratios in existing automobiles are made almost constant. Therefore, at low speed, the larger steering wheel angle needed increases drivers' physical workload especially in the case of a maneuver with large directional angle change such as parking, and may impair quickness in response necessary for a sudden lane change maneuver such as obstacle avoidance at low speed.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;On the contrary, at high speed, a relatively small steering angle input can generate comparatively large vehicle lateral acceleration, and this larger overall steering gain may necessitate drivers' more meticulous steering operation which can produce increased mental workload.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;In addition, for understeer vehicle, steering gain tends to decrease as lateral acceleration increases because of saturation in lateral force of the tire, and this may also reduce maneuverability in directional change, especially during cornering.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;In order to address these possible factors, a steering system in which the equivalent steering gear ratio increases (becomes lower geared) with the increase of vehicle speed, and decreases ( becomes higher geared ) with the increase of steering wheel angle was created, and its effects on driver-vehicle response and performance were studied.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper presents the selection of variable characteristics of steering gear ratio derived from observations of drivers' steering behavior and from the results of proving ground tests, and describes the mechanism of a steering gearbox which could realize the proposed steering characteristics, and the construction of such a steering system. The results of simulations and proving ground tests, which indicate improvement in performance as expected, are shown as well.&lt;/div&gt;
Modeling of a cavity filled with a plane multilayered dielectric using the method of auxiliary sources (2006)

A numerical technique is developed for the calculation of electromagnetic fields inside a cavity filled with multilayered dielectric. The primary field generated by a source is expressed in terms of the eigenmodes of the parallel-plate waveguide. The eigenmodes explicitly satisfy the boundary conditions on the top and bottom plates of the waveguide. As in the original method of auxiliary sources, auxiliary sources (ASs) and collocation points are introduced on the perimeter of the cavity on the sidewalls where the boundary conditions are imposed. Each AS is a source of the omni-directional radiation of the waveguide's eigenmode. The boundary conditions are satisfied separately for each eigenmode. As soon as the amplitude of an AS is calculated, it becomes possible to take into account the influence of the cavity's shape on the primary source. An example of two coaxial probes in a rectangular cavity is presented. This structure is also analyzed using Zeland Software's IE3D
On the analysis of WiFi communication and WiMAX network entry over single radios (2012)

Future wireless mobile devices will have to support a variety of heterogeneous access technologies while having a limited number of transceiver chains. One of the most challenging tasks remains how to support wireless access in one of the technologies, while preparing a “smooth transition” to another, especially to technologies with a lengthy network entry such as WiMAX. This work proposes an efficient way to organize a WiMAX network entry process while continuing a communication session with stringent QoS requirements via WLAN. We advocate the prioritization of the strict WiMAX timing over the contention-based WLAN channel access. Our results show the applicability of this approach over a wide range of mobile WiMAX parameters and identify bounds on the WiMAX downlink load for which the WiFi communication does not suffer quality distortions.
Transforming ultrasound basic research in to clinical systems (2014)

In late 1960s, Robert F. Heimburger, MD, Chief of Neurosurgery at Indiana University School of Medicine, started collaborating with William J. Fry and Francis J. Fry at Interscience Research Institute (IRI) in Champaign, IL. and treated brain cancer patients with HIFU. In 1970, Dr. Heimburger and Indiana University School of Medicine (IUMS) invited IRI to join IUMS and Indianapolis Center For Advanced Research, Inc. (ICFAR). In 1972, a dedicated Fortune Fry Research Laboratory (FFRL) was inaugurated to advance ultrasound research relevant for clinical use. In the ‘70s, an automated computer controlled, integrated B-mode, image-guided HIFU system (“the candy machine”) was developed that successfully treated brain cancer patients at IUMS. HIFU was found to be safe for the destruction of brain tumors. Later a second-generation brain HIFU device was developed to work with CAT or MR images. In 1974, the FFRL developed a first cardiac real-time, 2-D ultrasound scanner. Prof. H. Feigenbaum pioneered this imaging technique and formed “Echocardigraphy Society.” In 1978, an automated breast ultrasound system was successfully developed led to form Labsonics, Inc. that proliferated 300 scanners in 4 years. In 1986, the Sonablate system to treat prostate cancer was developed. The Sonablate has been used worldwide.
Brain‐derived neurotrophic factor applied to the motor cortex promotes sprouting of corticospinal fibers but not regeneration into a peripheral nerve transplant (2002)

Previous experiments from our laboratory have shown that application of brain-derived neurotrophic factor (BDNF) to the red nucleus or the motor cortex stimulates an increase in the expression of regeneration-associated genes in rubrospinal and corticospinal neurons. Furthermore, we have previously shown that BDNF application stimulates regeneration of rubrospinal axons into a peripheral graft after a thoracic injury. The current study investigates whether application of BDNF to the motor cortex will facilitate regeneration of corticospinal neurons into a peripheral nerve graft placed into the thoracic spinal cord. In adult Sprague Dawley rats, the dorsal columns and the corticospinal tract between T9 and T10 were ablated by suction, and a 5-mm-long segment of predegenerated tibial nerve was autograft implanted into the lesion. With an osmotic pump, BDNF was infused directly into the parenchyma of the motor cortex for 14 days. Growth of the corticospinal tract into the nerve graft was then evaluated by transport of an anterograde tracer. Anterogradely labeled corticospinal fibers were not observed in the peripheral nerve graft in animals treated with saline or BDNF. Serotinergic and noradrenergic fibers, as well as peripheral sensory afferents, were observed to penetrate the graft, indicating the viability of the peripheral nerve graft as a permissive growth substrate for these specific fiber types. Although treatment of the corticospinal fibers with BDNF failed to produce regeneration into the graft, there was a distinct increase in the number of axonal sprouts rostral to the injury site. This indicates that treatment of corticospinal neurons with neurotrophins, e.g., BDNF, can be used to enhance sprouting of corticospinal axons within the spinal cord. Whether such sprouting leads to functional recovery after spinal cord injury is currently under investigation.
On PID control of dynamic systems with hysteresis using a Prandtl-Ishlinskii model (2012)

This papers deals with PI and PID control of second order systems with an input hysteresis described by a modified Prandtl-Ishlinskii model. The problem of the asymptotic tracking of constant references is re-formulated as the stability of a polytopic linear differential inclusion. This offers a simple linear matrix inequality condition that, when satisfied with the chosen PI or PID controller gains, ensures the tracking of constant reference and also allows the designer to establish a performance index. The validation of the approach is performed experimentally on a Magnetic Shape Memory Alloy micrometric positioning system.
Angle-of-Attack Sweep with Mesh Adaptation for High-Lift Configurations (2022)

View Video Presentation: https://doi.org/10.2514/6.2022-0218.vid This paper reports an angle-of-attack (alpha) sweep study with mesh adaptation for two high-lift configurations: the JAXA Standard Model (JSM) and the High-Lift Common Research Model (CRM-HL) from the 3rd and the 4th AIAA High-Lift Prediction Workshops, respectively. Flow solutions are obtained by solving Reynolds-averaged Navier-Stokes equations with negative Spalart-Allmaras turbulence model (SA-neg), using a finite-element solver, FUN3D-SFE. The method of alpha continuation, where the flowfield at a certain angle-of-attack is initialized from the solution obtained at the previous angle-of-attack, is applied to adapted unstructured meshes. Since the meshes are continuously adapted, flowfield initialization on a particular mesh for a certain angle-of-attack�is done through linear interpolation of the solution from the previous mesh. Interpolated initial conditions from a lower angle-of-attack solution usually prevent massively separated solutions that may otherwise occur with impulsive initial conditions. For both JSM and CRM-HL models, forward alpha continuations (increasing alpha) are performed. The resulting solutions and the meshes, at selected �, are further adapted to larger meshes to get mesh converged force values. Starting from a post-stall solution, a reverse alpha�continuation (decreasing alpha) is also done for the JSM model, resulting in the formation of a hysteresis loop. For both models, the skin frictions and streamlines are compared with the wind-tunnel oil flow images, and the lift and pressure coefficients are compared with the wind-tunnel values.
Implicit Learning of Temporal Discriminations in Perception (1997)

We measured the temporal accuracy of signal transfer in the brain by means of periodic pulse stimuli in various sensory modalities using an adaptive threshold algorithm. Trains of supra-threshold signal pairs in 0° or 180° phase shifts appeared, and the subject indicated whether the signals of each pair in a train were simultaneous or not at various nominal frequencies of the pairs. The signals were spatially separate flashes of light, clicks, tactile pulses, or combinations thereof in intermodal comparisons. Temporal discrimination thresholds involving one signal in central photopic vision and the other in audition or tactile presentation to the finger tips did not exceed frequencies from 3 to 8 Hz, and in vision alone the average synchronism thresholds were about 10 Hz (SOA 0.05 s with 0.008 s pulses). The practice derived from 9 experimental sessions during 6 weeks improved temporal accuracy by factors ranging from 1.2 to 2.0 on the average in a sample of 33 naive subjects (university students), although no explicit feedback was given. The practice effect was lasting, for the average performance decrement was only 9% in 7 months. Thus, a considerable temporal modifiability must exist in the brain because a large learning effect was found in the simple temporal synchronism discrimination tasks.
MODELING OF ION TRANSPORT IN HARDENED CEMENT PASTE CONSIDERING CALCIUM LEACHING (2012)

Ca溶脱に伴うセメント硬化体の変質を考慮したセメント硬化体中のイオン移動予測モデルを構築した。予測モデルではNernst-Plank式、電気的中性条件、Debye-Huckel式に基づくイオン移動式を用いた。これより、セメント硬化体中の複数イオンの移動を経時的に追跡でき、複数イオンの濃度分布を予測することが可能である。また、セメント硬化体のCa溶脱機構はBuilの固液平衡モデルに従うとし、Ca溶脱に伴う拡散性能の変化は、セメント硬化体の3次元空間配置イメージによる拡散係数予測モデルを用い形状係数を定義することにより考慮した。構築を行ったイオン移動予測モデルの妥当性を検証するため、Ca溶脱率、また塩化物イオンの浸透量の予測値と実測値の比較を行った。
Myxoglobulosis of the Appendix in a Postpartum Patient (2004)

A 23-year-old female underwent a cesarean section for breech presentation at term. Her postpartum course was complicated by multiple admissions for pelvic pain presumed to be endometritis. Her symptoms were temporarily alleviated with intravenous antibiotics during each hospitalization. Imaging to evaluate persistent abdominal pain revealed a large cystic right lower quadrant mass adjacent to the ovary. Findings at diagnostic laparoscopy included a 15-cm × 4-cm appendix with pathology confirming myxoglobulosis. This case describes the only reported case of myxoglobulosis of the appendix presenting as a rare cause of pelvic pain in a postpartum patient. (J GYNECOL SURG 20:127)
406 Effects of modified yeast cell wall extract on gut health and growth of newly weaned pigs under chronic dietary challenges of aflatoxin, deoxynivalenol, and fumonisin (2017)

The objective of this study was to evaluate the effects of modified yeast cell wall extract at 2 g/kg (YCWE; Integral A+, Alltech, Lexington, KY) on growth and health of pigs fed diets with aflatoxin (180 µg/kg), deoxynivalenol (1 mg/kg), and fumonisin (9 mg/kg). Forty-eight pigs (24 barrows and 24 gilts at 21 d of age with 6.0 ± 0.6 kg BW) were randomly allotted to 4 treatments (2 × 2 factorial arrangement) with 12 pens per treatment, and fed the experimental diets for 48-d. Factors were mycotoxin and YCWE. Experimental diets were formulated to meet the requirement suggested by the NRC (2012) in 2 phases (phase 1 for 20-d and phase 2 for 28-d). Body weight and feed consumption were measured every 5-d in phase 1 and weekly in phase 2. On d 14 and 45, all pigs were bled to collect serum for biochemical analysis and other measurements. On d 48, all pigs were euthanized to collect jejunal tissue and mucosa. Tissue was used to measure histology. Mucosa and serum were used to determine tumor necrosis factor-α, malondialdehyde, protein carbonyl (PC), and immunoglobulins (IgA and IgG). Data were analyzed using the Mixed procedure in SAS with 2 factors and sex as fixed effects and initial BW as a random effect. Overall, mycotoxin reduced (P < 0.05) BW (37.8 to 31.1 kg), ADG (481 to 416 g/d), and ADFI (726 to 601 g/d). The YCWE tended to improve G:F (P = 0.079, 0.670 to 0.691) and reduce WBC (P = 0.071, 18.7 to 16.3 × 103 cells/µL). Mycotoxins reduced (P < 0.05) villus height (526 to 515 µm), increased (P < 0.05) IgA (5.7 to 6.5 mg/g protein), and increased (P < 0.05) PC (2.32 to 2.67 nmol/mg protein) in the jejunum. The YCWE tended (P = 0.088) to increase villus height (515 to 523 µm), and reduced (P < 0.05) IgA (6.3 to 5.9 mg/g protein) and PC (2.6 to 2.4 nmol/mg protein) in the jejunum. Collectively, feeding diets with mycotoxin at moderate levels reduced growth and impaired gut health in newly weaned pigs. Supplemental YCWE could improve growth and gut health in newly weaned pigs at 3 to 10 wk of age.
Screening of Six Medicinal Plant Extracts Obtained by Two Conventional Methods and Supercritical CO2 Extraction Targeted on Coumarin Content, 2,2-Diphenyl-1-picrylhydrazyl Radical Scavenging Capacity and Total Phenols Content (2017)

Six medicinal plants <i>Helichrysum italicum</i> (Roth) G. Don, <i>Angelica archangelica</i> L., <i>Lavandula officinalis</i> L., <i>Salvia officinalis</i> L., <i>Melilotus officinalis</i> L., and <i>Ruta graveolens</i> L. were used. The aim of the study was to compare their extracts obtained by Soxhlet (hexane) extraction, maceration with ethanol (EtOH), and supercritical CO₂ extraction (SC-CO₂) targeted on coumarin content (by high performance liquid chromatography with ultraviolet detection, HPLC-UV), 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) scavenging capacity, and total phenols (TPs) content (by Folin-Ciocalteu assay). The highest extraction yields were obtained by EtOH, followed by hexane and SC-CO₂. The highest coumarin content (316.37 mg/100 g) was found in <i>M. officinalis</i> EtOH extracts, but its SC-CO₂ extraction yield was very low for further investigation. Coumarin was also found in SC-CO₂ extracts of <i>S. officinalis</i>, <i>R. graveolens</i>, <i>A. archangelica</i>, and <i>L. officinalis</i>. EtOH extracts of all plants exhibited the highest DPPH scavenging capacity. SC-CO₂ extracts exhibited antiradical capacity similar to hexane extracts, while <i>S. officinalis</i> SC-CO₂ extracts were the most potent (95.7%). EtOH extracts contained the most TPs (up to 132.1 mg gallic acid equivalents (GAE)/g from <i>H. italicum</i>) in comparison to hexane or SC-CO₂ extracts. TPs content was highly correlated to the DPPH scavenging capacity of the extracts. The results indicate that for comprehensive screening of different medicinal plants, various extraction techniques should be used in order to get a better insight into their components content or antiradical capacity.