gebhart/patrepeval huggingface dataset:
Interplay of diffusio- and thermo-osmotic flows generated by single light stimulus (2022)

Flow control is a highly relevant topic for micromanipulation of colloidal particles in microfluidic applications. Here, we report on a system that combines two-surface bound flows emanating from thermo-osmotic and diffusio-osmotic mechanisms. These opposing flows are generated at a gold surface immersed into an aqueous solution containing a photo-sensitive surfactant, which is irradiated by a focused UV laser beam. At low power of incoming light, diffusio-osmotic flow due to local photo-isomerization of the surfactant dominates, resulting in a flow pattern oriented away from the irradiated area. In contrast, thermo-osmotic flow takes over due to local heating of the gold surface at larger power, consequently inducing a flow pointing toward the hotspot. In this way, this system allows one to reversibly switch from outward to inward liquid flow with an intermittent range of zero flow at which tracer particles undergo thermal motion by just tuning the laser intensity only. Our work, thus, demonstrates an optofluidic system for flow generation with a high degree of controllability that is necessary to transport particles precisely to desired locations, thereby opening innovative possibilities to generate advanced microfluidic applications.
MULTI-CAMERA POSITIONING FOR AUTOMATED TRACKING SYSTEMS IN DYNAMIC ENVIRONMENTS (2010)

Most existing camera placement algorithms focus on coverage and/or visibility analysis, which ensures that the object of interest is visible in the camera's field of view (FOV). According to recent literature, handoff safety margin is introduced to sensor planning so that sufficient overlapped FOVs among adjacent cameras are reserved for successful and smooth target transition. In this paper, we investigate the sensor planning problem when considering the dynamic interactions between moving targets and observing cameras. The probability of camera overload is explored to model the aforementioned interactions. The introduction of the probability of camera overload also considers the limitation that a given camera can simultaneously monitor or track a fixed number of targets and incorporates the target's dynamics into sensor planning. The resulting camera placement not only achieves the optimal balance between coverage and handoff success rate but also maintains the optimal balance in environments with various target densities. The proposed camera placement method is compared with a reference algorithm by Erdem and Sclaroff. Consistently improved handoff success rate is illustrated via experiments using typical office floor plans with various target densities.
Intratumoral regulatory T cells: markers, subsets and their impact on anti‐tumor immunity (2019)

Regulatory T (Treg) cells play a crucial role in maintaining self-tolerance and resolution of immune responses by employing multifaceted immunoregulatory mechanisms. However, Treg cells readily infiltrate into the tumor microenvironment (TME) and dampen anti-tumor immune responses, thereby becoming a barrier to effective cancer immunotherapy. There has been a substantial expansion in the development of novel immunotherapies targeting various inhibitory receptors (IRs), such as CTLA4, PD1 and LAG3, but these approaches have mechanistically focused on the elicitation of anti-tumor responses. However, enhanced inflammation in the TME could also play a detrimental role by facilitating the recruitment, stability and function of Treg cells by up-regulating chemokines that promote Treg cell migration, and/or increasing inhibitory cytokine production. Furthermore, IR blockade may enhance Treg cell function and survival, thereby serving as a resistance mechanism against effective immunotherapy. Given that Treg cells are comprised of functionally and phenotypically heterogeneous sub-populations that may alter their characteristics in a context-dependent manner, it is critical to identify unique molecular pathways that are preferentially used by intratumoral Treg cells. In this review, we discuss markers that serve to identify certain Treg cell subsets, distinguished by chemokine receptors, IRs and cytokines that facilitate their migration, stability and function in the TME. We also discuss how these Treg cell subsets correlate with the clinical outcome of patients with various types of cancer and how they may serve as potential TME-specific targets for novel cancer immunotherapies.
Microstructure and Hardness of Scandium Trialuminide with Ternary Rare-Earth Additions (2007)

The microstructure of ternary Al3(Sc1-yREy) intermetallic compounds (where RE is one of the rare-earth elements La, Ce, Nd, Sm, Eu, Yb or Lu), was investigated as a function of RE concentration for 0&lt;y≤0.75. Alloys with La, Ce, Nd, Sm or Eu additions consist of a L12 phase containing a dendritic second phase with D019 (La, Ce, Nd, Sm) or C11b (Eu) structure. Alloys with Yb or Lu additions show a single L12 phase. The RE solubility limits at 1373 K in the L12-Al3(Sc1-yREy) phase are very low for La, Nd, Ce and Eu (0.08-0.41 at.% or y=0.0032-0.0164), low for Sm (3.22 at.% or y=0.1288) and complete for Yb and Lu. The lattice parameter of the L12 solid-solution increases linearly with RE concentration and the magnitude of this effect is correlated with the atomic size mismatch between Sc and the RE elements. The Vickers micro-hardness of the L12 solid-solution increases linearly with increasing RE concentration.
Real-Time, Autonomous, Precise Orbit Determination Using GPS (2001)

ABSTRACT: The desire for autonomously generated, rapidly available, and highly accurate satellite ephemeris is growing with the proliferation of constellations of satellites and the cost and overhead of ground tracking resources. Autonomous orbit determination (OD) based on observations from spaceborne GPS receivers is done on the ground in a postprocessing mode or in real time on board satellites. In an effort to estimate precise satellite ephemerides in real time on board a satellite, the Goddard Space Flight Center (GSFC) created the GPS Enhanced OD Experiment (GEODE) flight navigation software. This paper presents a characterization of GEODE performance and illustrates enhancements to GEODE designed to increase on-board, real-time total position accuracy and precision without increasing computational burden. Specifically, an alternative gravity field representation, a relative ionospheric error correction based on code-carrier divergence, and a dynamic model adjustment for filter tuning were investigated. Processing of flight data from TOPEX/Poseidon (T/P) indicates that total position accuracy at the meter level is possible in real time with the proposed enhancements to GEODEs.
CNS Hodgkin lymphoma (2008)

Central nervous system (CNS) involvement by Hodgkin lymphoma (HL) is rare. As a result, there is limited guidance for clinicians on how to manage these patients. Detailed information was collected on 16 patients, the largest number to date, with meningeal or parenchymal CNS-HL confirmed by histopathology (15) or CSF (1). Eight patients presented with CNS-HL at diagnosis, 2 of whom had isolated CNS disease, while 8 patients developed CNS-HL at relapse. Patients received a range of treatments including surgery or radiation alone, radiation with chemotherapy, or chemotherapy alone. Median overall survival for all 16 patients was 60.9 months from first diagnosis of HL (systemic or CNS) and 43.8 months from diagnosis of CNS-HL. Although a majority of patients have died, long-term survival is possible in patients who achieve a complete response to treatment, particularly those who present with CNS involvement or involvement of the CNS is the sole site of relapsed disease.
Antiviral therapy of orthopoxvirus infection (2011)

Click to launch & play an online audio visual presentation by Prof. Earl R. Kern and Prof. Mark N. Prichard on Antiviral therapy of orthopoxvirus infection, part of a collection of multimedia lectures.
Deposition of epitaxial yttria-stabilized zirconia on single-crystal Si and subsequent growth of an amorphous SiO2interlayer (1995)

Abstract A processing technique is developed to fabricate single-crystal yttria-stabilized zirconia (YSZ) on amorphous SiO2 on (100) single-crystal Si. The YSZ layer shows high crystallinity with an ion beam channelling minimum of 11 % from Rutherford backscattering. Even though there is a thick intervening amorphous SiO2 layer between the Si and the YSZ, the single-crystal YSZ layer is aligned with the crystal Si. The tilt and rotation variations are 0·64° and 1·11° respectively, based on X-ray diffraction Ω-rocking curves on [100] and π scans on [202] of YSZ films. The epitaxial nature of the YSZ on the thick SiO2 layer (from 10 to 100 nm) is further confirmed by high-resolution cross-sectional transmission electron microscopy analysis. This processing and the resulting multilayer structure might provide a new option for fabricating innovative microelectronic devices.
<title>World Wide Web telemedicine system</title> (1996)

We have designed a teleradiology and telemedicine architecture over the World-Wide Web using current HIS, RIS and PACS. Our implementation allows remote access to hypermedia medical record and automatic management of interactive communications between referring physician and consultants. Security and privacy issues are also discussed. Its successful use in a telemedicine trial to China involving hundreds of doctors has shown the potential trend of telemedicine over the World-Wide Web.
The CoWriter Project (2015)

This video (that accompanies the paper "When Children Teach a Robot to Write: An Autonomous Teachable Humanoid Which Uses Simulated Handwriting" by the same authors, and presented as well during this conference) presents the first results of the EPFL CoWriter project. The project aims at building a robotic partner which children can teach handwriting. The system allows for the learning by teaching paradigm to be employed in the interaction, so as to stimulate meta-cognition, empathy and increased self-esteem in the child user. It is hypothesised that use of a humanoid robot in such a system could not just engage an unmotivated student, but could also present the opportunity for children to experience physically-induced benefits encountered during human-led handwriting interventions, such as motor mimicry.
IV fosphenytoin in obese patients (2017)

The incidence of adverse events and the need for repeat loading antiepileptic medications was similar between the 2 groups. From our findings, the patients in our study did not receive empiric loading dose adjustments and the current method of loading fosphenytoin achieves similar outcomes, regardless of the patient's BMI.
Altered parathyroid set point to calcium in familial hypocalciuric hypercalcaemia (1984)

Changes in calcium concentration were induced by an infusion of disodium-EDTA or calcium in 2 members of a family suffering from hypocalciuric hypercalcaemia ( FHH ) associated with interstitial lung disease. These changes in calcium demonstrated an inverse linear relationship with the changes in serum parathyroid hormone (PTH). Infusion of EDTA in control subjects and in patients with an adenoma or hyperplasia of the parathyroid glands also showed inverse relationships between calcium and PTH. The correlation between serum calcium and serum PTH was significant over the range observed during the induced hypo- and/or hypercalcaemia in controls and in patients with FHH or adenoma. The regressions were, however, shifted relative to each other: in comparison with controls, the FHH was displaced upwards and to the right, although not as far as the adenomas. These findings suggest the existence of an elevated set point for extracellular calcium (or calciostat ) in FHH .
Automatically locating unnamed windows and inner frames for web regression testing (2017)

Selenium IDE is a glorious state-of-the-art integrated development environment for recording and playing Selenium test cases for web testing. However, it does not support automatically locating unnamed popup windows and inner frames, which impedes creating a sequence of test commands across different windows and inner frames. In this work, we extend Selenium IDE and propose a technique to dealing with this problem. The experimental results demonstrate the automation efficacy with 12 real world web pages and 36 pairwise test cases.
Multifunctional liquid lens (MLL) for variable focus and variable aperture (2017)

This paper presents a novel multifunctional liquid lens (MLL) based on electrowetting-on-dielectric (EWOD) actuation for high-performance miniature cameras. MLL firstly offers variable-focus and variable-aperture functions in a single lens system using sole EWOD actuation. The performance of MLL consisting of lens and iris units is experimentally verified. The variable-focus function of the lens unit and variable-aperture function of the iris unit are separately investigated using a prototype of MLL. Finally, as proof of concept, the simultaneous operations of variable-focus and variable-aperture functions of MLL are experimentally demonstrated using two transparent optical charts with the cloud and sun image.
Protein domain interfaces: characterization and comparison with oligomeric protein interfaces (2000)

The physical and chemical properties of domain-domain interactions have been analysed in two-domain proteins selected from the protein classification, CATH. The two-domain structures were divided into those derived from (i) monomeric proteins, or (ii) oligomeric or complexed proteins. The size, polarity, hydrogen bonding and packing of the intra-chain domain interface were calculated for both sets of two-domain structures. The results were compared with inter-chain interface parameters from permanent and non-obligate protein-protein complexes. In general, the intra-chain domain and inter-chain interfaces were remarkably similar. Many of the intra-chain interface properties are intermediate between those calculated for permanent and non-obligate inter-chain complexes. Residue interface propensities were also found to be very similar, with hydrophobic residues playing a major role, together with positively charged arginine residues. In addition, the residue composition of the domain interfaces were found to be more comparable with domain surfaces than domain cores. The implications of these results for domain swapping and protein folding are discussed.
Fabrication of Metal Oxide Nanoparticles by Highly Exothermic Reactions (2009)

Abstract The development of two methods using highly exothermic oxidation reactions to synthesize nanostructured oxide particles is described. The first method uses solution combustion to produce a high temperature front that moves through the sample and produces the nanoparticles. For example, Bi 2 O 3 nanoparticles are produced using a solution of molten metal nitrates and glycine. The glycine (fuel) is completely combusted during the thermal decomposition of the (oxidizer) nitrates and generates a temperature front that propagates through the sample. The second method produces nanoparticles by a self‐propagating high‐temperature reaction from stoichiometric powder mixtures of metal oxides (or carbonates) and carbon. The exothermic oxidation of the carbon generates a propagating high‐temperature front at a velocity in the range of 0.1–2.5 mm/s that converts the reactants to products. In both cases, the synthesis was completed within a few seconds. In both methods, a higher maximum combustion temperature and larger oxide particle size were obtained following an increase in the fuel concentration. The main advantages of these synthesis methods technologies are simplicity, short reaction time, low reactant costs, and no external energy consumption. The methods can be used to synthesize nanoparticles for various applications including nanoenergetic materials, catalysts and electronic components.
Properties of Pure Water (2007)

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Dynamic Radiologic Evaluation of Horizontal Instability in Acute Acromioclavicular Joint Dislocations (2010)

Horizontal instability of the distal clavicle in acute AC joint injuries represents an indication for surgical treatment. Dynamic axillary radiologic evaluation may detect previously missed unstable injuries. This evaluation might be relevant when deciding on surgical AC joint stabilization.
Online First All the Time and More Continuing Medical Education Credit Too! (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Lactate oxidase: Expression of the gene in Escherichia coli and studies of the reaction mechanism through active site mutations. (1993)

L-Lactate-2-monooxygenase from Mycobacterium smegmatis catalyzes the reaction of L-lactate with oxygen yielding acetate, carbon dioxide and water. The gene for lactate oxidase was expressed in E. coli under control of the T 7 polymerase promoter. Based on the homology of lactate oxidase with the amino acid sequence of two related enzymes, flavocytochrome b$\sb2$ and glycolate oxidase, for which crystal structures are known, several amino acid residues were postulated to participate in catalysis. Tyrosine 44 and arginine 293 are assumed to stabilize the binding of lactate and were replaced by phenylalanine and lysine residues, respectively. Tyrosine 152 is assumed to participate in the binding of substrate and in the stabilization of a reaction intermediate and was mutated to phenylalanine. Histidine 290 was postulated to initiate catalysis by abstraction of a proton from the substrate and was replaced with glutamine. Lysine 266 may be in the appropriate position relative to the flavin-N(1) to stabilize a negatively charged hydroquinone during turnover. It was mutated to a methionine. All of the substitutions at the active site resulted in reduced catalytic efficiency. It appears that the main effect is on the ability of the enzymes to stabilize the transition state. In H290Q the capacity to generate the transient substrate carbanion has presumably been removed and the enzyme is essentially inactive. R293K, Y44F and Y152F bind lactate as well as the wild type enzyme, but show a substantially higher dissociation constant for the transition state analog oxalate. A linear relationship exists between the rate of reduction and the capacity to bind oxalate. For K266M it could be shown that the properties of lactate oxidase which had led to the initial postulation of a positively charged amino acid residue, such as tight binding of sulfite and the stabilization of an anionic semiquinone, were affected. In contrast to the wild type enzyme, binding of sulfite was about 17 000 fold weaker, and the semiquinone was no longer thermodynamically stable.
Y… otros estilos de vida (2000)

Es grato saber que en la actualidad existen dentro de la psicología una corriente denominada eco-psicología, que se dedica a estudiar la relación del hombre con el medio ambiente. Esta forma terapéutica en vez de enfocarse en los sentimientos del paciente por su trabajo, su vida amorosa o su familia, intenta colocar en consideración la relación de las personas con la naturaleza y, de esta manera encontrar las posibles causas de los problemas. Se trata de aclarar por ejemplo, si una depresión permanente es producto de las relaciones matrimoniales o un lamento por las especies en extinción. La eco-psicología es hasta el momento un movimiento marginal y, uno de sus representantes es Theodore Rozak, profesor de historia de la universidad de California, quien dice: “es probable que una gran cantidad de lo que surge en la terapia como sueños, temores y tristezas tenga origen en el medio ambiente.
Burst pacemaker activity of the sinoatrial node in sodium–calcium exchanger knockout mice (2015)

In sinoatrial node (SAN) cells, electrogenic sodium-calcium exchange (NCX) is the dominant calcium (Ca) efflux mechanism. However, the role of NCX in the generation of SAN automaticity is controversial. To investigate the contribution of NCX to pacemaking in the SAN, we performed optical voltage mapping and high-speed 2D laser scanning confocal microscopy (LSCM) of Ca dynamics in an ex vivo intact SAN/atrial tissue preparation from atrial-specific NCX knockout (KO) mice. These mice lack P waves on electrocardiograms, and isolated NCX KO SAN cells are quiescent. Voltage mapping revealed disorganized and arrhythmic depolarizations within the NCX KO SAN that failed to propagate into the atria. LSCM revealed intermittent bursts of Ca transients. Bursts were accompanied by rising diastolic Ca, culminating in long pauses dominated by Ca waves. The L-type Ca channel agonist BayK8644 reduced the rate of Ca transients and inhibited burst generation in the NCX KO SAN whereas the Ca buffer 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (acetoxymethyl ester) (BAPTA AM) did the opposite. These results suggest that cellular Ca accumulation hinders spontaneous depolarization in the NCX KO SAN, possibly by inhibiting L-type Ca currents. The funny current (If) blocker ivabradine also suppressed NCX KO SAN automaticity. We conclude that pacemaker activity is present in the NCX KO SAN, generated by a mechanism that depends upon If. However, the absence of NCX-mediated depolarization in combination with impaired Ca efflux results in intermittent bursts of pacemaker activity, reminiscent of human sinus node dysfunction and "tachy-brady" syndrome.
Periodontal and Computer Tomography Scanning Evaluation of Endosseous Implants in Conjunction With Sinus Lift Procedure. A 6‐Case Series (1999)

The aim of the present study was to evaluate endosseous implants in conjunction with the sinus lift procedure using periodontal parameters and computed tomography (CT) scanning. In 6 patients, 8 sinus lift procedures were performed to the atrophic posterior maxilla. Fourteen endosseous implants were placed. The condition of the peri-implant mucosa was assessed postoperatively at an average of 31 months using periodontal parameters such as plaque index, probing depth, clinical attachment level, and bleeding on probing. All the implants were maintained in a clinically healthy condition throughout the observation period. CT images revealed the difference in the morphology of the sinus floor between the locations of the block-shaped bone and the small pieces of bone which were both grafted. The results indicated that endosseous implants in conjunction with the sinus lift procedure could be maintained by monitoring the periodontal parameters.