gebhart/patrepeval huggingface dataset:
The mechanisms of graphene-based materials-induced programmed cell death: a review of apoptosis, autophagy, and programmed necrosis (2017)

Graphene-based materials (GBMs) are widely used in many fields, including biomedicine. To date, much attention had been paid to the potential unexpected toxic effects of GBMs. Here, we review the recent literature regarding the impact of GBMs on programmed cell death (PCD). Apoptosis, autophagy, and programmed necrosis are three major PCDs. Mechanistic studies demonstrated that the mitochondrial pathways and MAPKs (JNK, ERK, and p38)- and TGF-β-related signaling pathways are implicated in GBMs-induced apoptosis. Autophagy, unlike apoptosis and necroptosis which are already clear cell death types, plays a vital pro-survival role in cell homeostasis, so its role in cell death should be carefully considered. However, GBMs always induce unrestrained autophagy accelerating cell death. GBMs trigger autophagy through inducing autophagosome accumulation and lysosome impairment. Mitochondrial dysfunction, ER stress, TLRs signaling pathways, and p38 MAPK and NF-κB pathways participate in GBMs-induced autophagy. Programmed necrosis can be activated by RIP kinases, PARP, and TLR-4 signaling in macrophages after GBMs exposure. Though apoptosis, autophagy, and necroptosis are distinguished by some characteristics, their numerous signaling pathways comprise an interconnected network and correlate with each other, such as the TLRs, p53 signaling pathways, and the Beclin-1 and Bcl-2 interaction. A better understanding of the mechanisms of PCD induced by GBMs may allow for a thorough study of the toxicology of GBMs and a more precise determination of the consequences of human exposure to GBMs. These determinations will also benefit safety assessments of the biomedical and therapeutic applications of GBMs.
Perovskite Photovoltaics with Outstanding Performance Produced by Chemical Conversion of Bilayer Mesostructured Lead Halide/TiO2 Films (2016)

A new method of producing high-quality perovskite films via sequential deposition is presented, introducing a PbX2 capping layer that is endowed with a network of interconnected nanopores. The mesoporous lead halide architecture provides a powerful tool to accomplish rapid and complete transformation of lead halide into the perovskite for high-efficiency solar cells.
<title>Laser-induced breakdown spectroscopy: a new and powerful technique for pollutant diagnostics</title> (1996)

Laser Induced Breakdown Spectroscopy is a new and powerful diagnostic technique for atomic and ionic pollutants detection. In situ and laboratory tests show the high sensitivity of this technique for metallic pollution detection in atmosphere, industrial exhausts and soil.
Total synthesis of the macrolide, zearalenone (1967)

D. Taub, N. N. Girotra, R. D. Hoffsommer, C. H. Kuo, H. L. Slates, S. Weber and N. L. Wendler, Chem. Commun. (London), 1967, 225b DOI: 10.1039/C1967000225B
Place de la phytothérapie dans la prise en charge des troubles du sommeil des enfants (2015)

International audience
Exploring Photogenerated Molecular Quartet States as Spin Qubits and Qudits (2021)

Photogenerated molecular spin systems hold great promise for applications in quantum information science because they can be prepared in well-defined spin states at modest temperatures, they often exhibit long coherence times, and their properties can be tuned by chemical synthesis. Here, we investigate a molecular spin system composed of a 1,6,7,12-tetra(4-<i>tert</i>-butylphenoxy)perylene-3,4:9,10-bis(dicarboximide) (PDI) chromophore covalently linked to a stable nitroxide radical (TEMPO) by optical and electron paramagnetic resonance (EPR) techniques. Upon photoexcitation of the spin system, a quartet state is formed as confirmed by transient nutation experiments. This quartet state has spin polarization lifetimes longer than 0.1 ms and is characterized by relatively long coherence times of ∼1.8 μs even at 80 K. Rabi oscillation experiments reveal that more than 60 single-qubit logic operations can be performed with this system at 80 K. The large magnitude of the nitroxide <sup>14</sup>N hyperfine coupling in the quartet state of PDI-TEMPO is resolved in the transient EPR spectra and leads to a further splitting of the quartet state electron spin sublevels. We discuss the properties of this photogenerated multilevel system, comprising 12 electron-nuclear spin states, in the context of its viability as a qubit for applications in quantum information science.
A Distributed Fair Auto Rate Medium Access Control for Wireless LANs (2007)

The IEEE 802.11 protocol provides a physical multi-rate capability. Existing auto rate schemes concentrate on passively tuning the rate according to the channel strength, but cannot exploit the time-variation of fading channel. In this paper, by means of an analytical model, the authors derive the rule maximizing the throughput of RTS/CTS based multi-rate WLANs. Then, based on the obtained rule the authors propose a distributed fair auto rate medium access control scheme. With the proposed scheme, after receiving a RTS frame, the receiver selectively returns the CTS frame according to both the signal-to-noise ratio of the RTS frame and current network status. Moreover, the returned CTS carries a piggyback information indicating the maximum feasible rate. The key feature of the proposed scheme is that it is capable of positively exploiting time-varying fading channel and maintaining fairness in asymmetric situation where the distribution of SNR varies with stations. Extensive simulation results show that the proposed scheme outperforms the existing fairness schemes in time-varying channel conditions.
Impact of Rising Fuel Prices on Prevailing Traffic Speed on Freeway in Houston, Texas (2009)

This study investigates the impact of the 50% rise of gasoline prices over a nine-month period (October 2007 to June 2008) on the free-flow traffic speeds on freeway in Houston, Texas. The impact was estimated using a multiple linear regression technique with controls for time of day, day of week, and season. Three separate models were developed for the 15th, 50th, and 85th percentile traffic speeds, which represent motorists whose value of time is low, medium, and high. These groups of motorists decreased their free-flow speeds from the baseline speed by 5.5%, 3.9%, and 3.1%, respectively, when the gasoline price rose by $2.00 per gallon.
POLYNITROGEN REAGENTS, IN METAL SEPARATION. PART 5 THE EXTRACTION OF URANIUM(VI) FROM SULPHURIC, NITRIC AND HYDROCHLORIC ACID MEDIA WITH ALKYLDIAMHONIUM EXTRACTANTS. (1985)

ABSTRACT A variety of a1kyldiammonium extractants (tertiary and quaternary) were used to extract uranium(VI) from sulphuric, nitric and hydrochloric acid media. The performance of these extractants was compared with that of Aliquat-336 and Alamine-336. Extractions from dilute uranium(VI) solutions were carried out in order to simulate conditions employed in the local mining industry
Gelatin Sheet Incorporating Basic Fibroblast Growth Factor Enhances Healing of Devascularized Sternum in Diabetic Rats (2001)

Background Poor healing of the sternum often limits the use of bilateral internal thoracic arteries (BITAs) after coronary bypass surgery in diabetic patients. We have reported that a gelatin sheet that incorporates basic fibroblast growth factor (bFGF) accelerates sternal healing after BITA removal in normal rats. This study evaluated the effects of the above method for sternal healing in diabetic animals. Methods and Results Diabetic Wistar rats with blood glucose levels &gt;400 mg/dL and body-weight loss &gt;20 g were established by a single intravenous injection of streptozotocin (55 mg/kg). After median sternotomy and BITA removal, 16 diabetic rats received either a gelatin sheet that incorporated bFGF (100 μg/sheet) on the posterior table of the sternum (FGF group, n=9) or no gelatin sheet (control, n=7). Peristernal blood flow, as measured by a noncontact laser Doppler 4 weeks after surgery in the FGF group, recovered to the preoperative level (106±10% versus 82±9%, P &lt;0.01), and marked angiogenesis was also observed around the sternum in the FGF group (30.5±3.2 versus 15.8±2.7 vessels/unit area, P &lt;0.01). Deep sternal wound complications developed in 5 control rats but only in 1 rat in the FGF group ( P &lt;0.05). In the FGF group, histological examination showed improved sternal healing (excellent in 6 rats and slow/poor healing in 3). Bone mineral content as assessed by dual-energy x-ray absorptometry was greater in the FGF group (75.9±18.1 versus 48.9±10.7 mg, P &lt;0.05). Bone mineral density of the sternum was similar between the 2 groups. Conclusions A gelatin sheet that incorporates bFGF may offset sternal ischemia and accelerate sternal bone regeneration and healing, even in diabetic patients.
Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A (2000)

A defect of the gene for p94 (calpain 3), a skeletal muscle-specific calpain, is responsible for limb girdle muscular dystrophy type 2A (LGMD2A), or 'calpainopathy', which is an autosomal recessive and progressive neuromuscular disorder. To study the relationships between the physiological functions of p94 and the etiology of LGMD2A, we created transgenic mice that express an inactive mutant of p94, in which the active site Cys129 is replaced by Ser (p94:C129S). Three lines of transgenic mice expressing p94:C129S mRNA at various levels showed significantly decreased grip strength. Sections of soleus and extensor digitorum longus (EDL) muscles of the aged transgenic mice showed increased numbers of lobulated and split fibers, respectively, which are often observed in limb girdle muscular dystrophy muscles. Centrally placed nuclei were also frequently found in the EDL muscle of the transgenic mice, whereas wild-type mice of the same age had almost none. There was more p94 protein produced in aged transgenic mice muscles and it showed significantly less autolytic degradation activity than that of wild-type mice. Although no necrotic-regenerative fibers were observed, the age and p94:C129S expression dependence of the phenotypes strongly suggest that accumulation of p94:C129S protein causes these myopathy phenotypes. The p94:C129S transgenic mice could provide us with crucial information on the molecular mech-anism of LGMD2A.
Mycotoxin production by Alternaria species grown on apples, tomatoes, and blueberries (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMycotoxin production by Alternaria species grown on apples, tomatoes, and blueberriesE. E. Stinson, D. D. Bills, S. F. Osman, J. Siciliano, M. J. Ceponis, and E. G. HeislerCite this: J. Agric. Food Chem. 1980, 28, 5, 960–963Publication Date (Print):May 1, 1980Publication History Published online1 May 2002Published inissue 1 May 1980https://pubs.acs.org/doi/10.1021/jf60231a040https://doi.org/10.1021/jf60231a040research-articleACS PublicationsRequest reuse permissionsArticle Views515Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electrochemical Healing of Dendrites in Garnet-Based Solid Electrolytes (2021)

Garnet oxides are a promising material family for solid-state batteries (SSBs). Dendrite formation in solid electrolytes critically limits the applicability of SSBs because of limiting coulombic efficiency and power capability. Herein, the authors report in operando electrochemical healing of dendrites in a garnet-based solid electrolyte (SE). Dendrites are deliberately formed at high operational current density (2 mA cm −2 ) beyond the critical current density (0.55 mA cm −2 ) of the garnet SE. Electrochemical impedance spectroscopy and scanning electron microscopy were used to confirm dendrite growth in the SE. Dendrites were subsequently healed electrochemically via plating and stripping at 20 and 1 µ A cm −2 current densities. Removal of dendrites was shown by an increase in bulk and interfacial resistance and a progressive increase in polarization during galvanostatic plating and stripping. High local current density at the dendrite tips was identified as the mechanism for preferentially removing dendrites electrochemically. Dendrite detection and healing methods discussed here are crucial for extending the life of SSBs. Figure 1
From genes to decisions: evolving views of genotype-based management in MEN 2. (2004)

Diagnosis and management of MEN 2 has evolved considerably since the identification of the underlying disease mutations in the RETproto-oncogene. Presymptomatic detection and prophylactic surgical intervention are now the accepted standard of care. The strong correlation of disease phenotype and mutation genotype has already also allowed us to develop mutation-guided management strategies to optimize time ot intervention and schedule follow-up and management. As our understanding of the depth of these correlations increases we look forward to better refining our management regimes to fit both the best care requirements and the quality of life needs of the MEN 2 patient.
Force and moment generation of fiber-reinforced pneumatic soft actuators (2013)

Soft actuators are found throughout nature from elephant trunks to round worms, demonstrating large specific forces without the need for sliding components. These actuators offer impact resilience, human-safe interaction, versatility of motion, and scalability in size. Biological structures often use a fiber-reinforcement around a fluid filled elastomeric enclosure, in which the elastomeric material will capture the distributed pressure and transfer it to the fibers, which will in turn direct the forces to the ends. We previously discovered an entire domain of fiber-reinforced elastomeric enclosures (FREEs), of which McKibben actuators are a small subset. The range of forces and moments possible with FREEs has not been previously investigated. 45 FREE actuators across the span of fiber angle configurations were fabricated and tested. The reaction force and moment of each actuator was determined across a gamut of pressures. Analytical models were generated using a variety of simplifying assumptions. These models were created to provide a closed form expression that models the force and moment data. The models were compared to the experimental values to determine their fit; this provides an understanding of which simplifying kinematic assumptions best represent the experimental results. Interpolated experimental results and the analytical models are all graphically represented for use as an intuitive design tool.
How hot are single cells? (2020)

Large changes in energy metabolism are associated with minimal alterations in surface temperature of isolated mammalian cells.
High-Temperature Microwave Dielectric Properties and Processing of JSC-1AC Lunar Simulant (2013)

Successful development of extraterrestrial microwave heating technologies depends on the study of the dielectric properties that control the microwave heating behavior of simulants and regoliths. Microwave heating may serve many lunar applications including heating the regolith for lunar surface dust stabilization, oxygen production, building materials, and mineral refinement. The dielectric properties (dielectric constant, ε′, and loss factor, ε″) of the lunar simulant, JSC-1AC, were measured at 2.45 GHz microwave frequency from room temperature to 1,100°C. The dielectric loss tangent and half-power depth were calculated from the measured properties. The loss tangent increased from a low value of 0.02 at room temperature to a high value of 0.31 at 1,100°C, indicating increased efficiency of microwave absorption at higher temperatures. The low temperature loss tangent indicated that relatively slow, low efficiency heating would be expected at room temperature. The microwave heating experiments confirmed weak heating related to absorption below 250°C, and increasingly strong absorption above 250°C, leading to rapid heating and melting or the so-called thermal runaway of JSC-1AC. Heating with microwaves as the only energy source produced a thermal runaway with wide variations in the JSC-1AC, such as fully molten glass, with unsintered loose particulate located millimeters away. The addition of a supplemental radiant heat source to the microwave mitigated the thermal runaway effect and produced uniform solid materials from the JSC-1A lunar simulant. The room temperature dielectric properties of JSC-1AC were measured and found to be comparable with the range of published lunar regolith properties, making JSC-1AC a reasonable starting point for microwave heating and computational modeling studies.
Disturbance-free operation of five-phase induction machine with one stator winding open circuited (2010)

A disturbance free operation method of five-phase induction machine with one stator winding opened is presented in this paper. The four healthy phase currents are derived by keeping stator magnetomotive force unchanged when a stator winding opened. Based on symmetrical component method and equivalent circuits of five-phase induction machine, voltage of the four healthy phases, which is supply to the fault machine, is obtained. The torque and rotor speed are not changed remarkably, and the currents of four healthy phases are controlled in balance. The presented method is verified by simulation results.
Serum Neuron-Specific Enolase, Carnosinase, and Their Ratio in Acute Stroke (1996)

We believe that measurement of NSE, HSC, or their ratio may be useful in the assessment of patients with acute stroke with respect to diagnosis and prediction of clinical outcome.
ChemInform Abstract: Synthesis of Peptides Containing (S)‐α‐Methylserine. (1988)

Abstract The title peptides (III) are synthesized by coupling of the Mse ester (I) with respective components (II).
Primary mediastinal embryonal carcinoma in association with Klinefelter's syndrome (1981)

Germ cell tumors, particularly those of extragonadal origin, have a rare and only recently recognized association with Klinefelter's syndrome. A case of a primary mediastinal embryonal cell carcinoma in a 16-year-old male with Klinefelter's syndrome is reported.
The role of sodium transport in thyroid thermogenesis. (1979)

The hypothesis that augmentation of Na+ transport activity mediates a significant fraction of thyroid thermogenesis is supported by studies on a wide range of target tissues. Recent criticisms based on theoretical and experimental considerations do not appear to negate the validity of this concept. A basic difficulty that remains to be resolved, however, is the development of techniques for assessing the contribution of the Na+ transport pathway to energy turnover in the intact animal.
Combined analysis of gene expression and clinical data in the severe asthma U-BIOPRED cohorts (2014)

Introduction In order to gain new insights into the biology of severe asthma, correlation analysis was performed between clinical and transcriptome data obtained from biopsies and bronchial brushings in the U-BIOPRED cohorts. Objective Discovering transcriptomic fingerprints associated with clinically relevant traits of severe asthma. Methods Gene expression data obtained from bronchial biopsies and brushing samples from severe asthma subjects and normal healthy volunteers (52 vs 41 and 60 vs 46 samples respectively) were compared using the R package WGCNA (Langfelder &amp; Horvath, BMC Bioinformatics, 2008; 9, 559) and correlated to the clinical data. Groups of genes (modules) were determined by topological overlap matrix analysis. Results Significant correlations were found between specific modules and severe asthma clinical traits in both biopsies (see table) and brushings. Interestingly, 214 genes (module 1) were correlated to the number of exacerbations in the previous year. In addition, 19 significant correlations were identified between gene modules and clinical traits from analysis of the brushing transcriptome. Module (gene number) Clinical trait Correlation Pvalue 1 (214) Number of exacerbations previous year 37.5 % 3.46E-03 2 (254) Atopy Skin Prick Test -28.3 % 2.96E-02 3 (14153) Pack/years 31.7 % 1.44E-02 Conclusions A cutting-edge bioinformatics methodology was adapted for the analysis of severe asthma transcriptomes. Several gene modules were found to be correlated with specific clinical traits and will be presented. Funded by the Innovative Medicines Initiative (U-BIOPRED: IMI n°115010; eTRIKS: IMI n°115446).
Coverage and capacity self-optimisation in LTE-Advanced using active antenna systems (2016)

In order to enhance the Long Term Evolution (LTE) network performance, the Third Generation Partnership Project (3GPP) introduced Coverage and Capacity Optimisation (CCO) in the context of Self Organising Network (SON). Antenna parameters (i.e. azimuth, electrical tilt etc.) play a key role in CCO and have a significant impact on the users' Quality of Service (QoS). In this paper, a novel metric, to evaluate the cells performance, that consider several performance indicators, is introduced. Furthermore, a distributed CCO algorithm is proposed which has three distinct phases. The first phase is to determine the target cell, the second phase adjust the antenna parameters for the target and neighbouring cells and in the last phase the optimum antenna parameters for the target and neighbouring cells is determined. The simulation results show significant improvement in the overall network performance with the proposed CCO algorithm. In particular, the target cell average performance can be improved by 16.75%.
Problem solving approach in data management (1975)

This paper looks at an artificial intelligence control program required for a system which accepts queries to a data base which consists of both data and program modules. Using a problem solving approach, the data base structure and the program modules specify the initial world model. The operators consist of functions which look through sets in the data base and the actual program modules themselves. The goal is the query which requests data and/or processes. The control program determines the path which maps through the data base and the program modules in a manner which satisfies the predicate calculus constraints and the goal. Real examples of how this system is being used for a large scale data base is included.
Classification and Identification of Bacteria by Mass Spectrometry and Computational Analysis (2008)

With the method for bacterial analysis, we could identify fire blight pathogens from a variety of biological sources. The method can be used for a number of additional bacterial genera. Moreover, the mass spectrometry approach presented allows the integration of data from different biological levels such as the genome and the proteome.