gebhart/patrepeval huggingface dataset:
Electrical insulation systems for the ITER Central Solenoid Model Coil (1999)

Insulation systems developed by Composite Technology Development, Inc., have been fabricated specifically for use in the US section of the International Thermonuclear Experimental Reactor (ITER) Central Solenoid (CS) Model Coil. The insulation system used in these fusion devices must be capable of withstanding significant mechanical loads at cryogenic temperatures and enduring high doses of radiation, all without compromising their electrical insulation properties. Two materials that have seen extensive use in the CS Model Coil are the CTD-112P tetrafunctional epoxy pre-preg system and the CTD-618 epoxy system. Fabrication methods for these materials were developed and implemented specifically for use on the model cell. The CTD-112P system has been successfully used as the primary turn insulation, and as such, has been tested extensively for its mechanical and electrical properties, before and after irradiation. The CTD-618, a room-temperature cure system, has been specified as the insulation system for repair of damaged turn insulation and also as the insulation for the noncritical areas of the tension links and terminations. The development of these materials and the method of application for each of these materials as they apply to the model coil are examined. Pertinent mechanical and electrical properties are also analyzed.
Abstract WP210: Aptamer Inhibitor Of Von Willebrand Factor Induces Thrombolysis And Improves Vascular Patency Upon Immediate And Delayed Treatment Of Stroke In An In Vitro Microfluidic Model (2023)

Von Willebrand factor (VWF) is critical in arterial thrombosis. Previous studies have shown that aptamer BB-031, a VWF inhibitor, induces thrombolysis in vivo in ischemic stroke models, making it a promising stroke therapeutic. We hypothesized that BB-031 will induce thrombolysis in an ex vivo ischemic stroke model and that advanced imaging techniques will provide mechanistic information. A microfluidic model was utilized to simulate ischemic stroke and drug delivery without disturbing the occluding thrombus. Heparinized whole blood was obtained from healthy volunteers (N=10). A gravity-based constant pressure microfluidic system mimicking arterial perfusion induced occlusive thrombosis at a collagen-coated region of stenosis. After resting for 0, 3, or 6 hours to allow retraction in situ thrombi were reperfused with blood containing 1692nM (~1mg/kg) BB-031, 0.7nM alteplase (ALT), 0.7nM tenecteplase (TEN), or vehicle 500um upstream of the thrombus using a separate inlet. Platelets were labelled prior to thrombus formation and reperfusion using fluorescent anti-CD41. Thrombolysis and patency were then monitored for 2hrs via outlet mass recording and z-stacked immunofluorescent imaging. Upon immediate reperfusion, 1692nM (~1mg/kg) BB-031 increased mean mass output by 0.250±0.629g compared to 0.031±0.065g with vehicle, 0.074±0.061g with ALT, and 0.101±0.150g with 0.7nM TEN. After a 3-hour retraction period, BB-031 reperfusion mean mass output was 0.951±1.279g compared to 0.301±0.380g with vehicle, 0.412±0.681g with ALT, and 0.569±0.714g with TEN. After 6-hours resting, reperfusion mass output increased by 1.354±1.433g with BB-031, 0.368±0.538g with vehicle, 0.158±0.195g with ALT, and 0.520±0.539g with TEN. Representative z-stacked renderings of the thrombus pre and post reperfusion from a 0-hour resting period show a volumetric decrease in thrombus size of 39% with BB-031 compared to 25% and 18% reduction with vehicle and ALT respectively in a donor-matched dataset. BB-031 improves patency in a microfluidic model of biofidelic thrombolysis compared to current standards of care, which is enhanced at 3 and 6 hours post-occlusion. This may be due to VWF-dependent lysis resulting in reduced thrombus volume.
Differential expression of microRNAs and other small RNAs in barley between water and drought conditions (2014)

Drought is a major constraint to crop production, and microRNAs (miRNAs) play an important role in plant drought tolerance. Analysis of miRNAs and other classes of small RNAs (sRNAs) in barley grown under water and drought conditions reveals that drought selectively regulates expression of miRNAs and other classes of sRNAs. Low-expressed miRNAs and all repeat-associated siRNAs (rasiRNAs) tended towards down-regulation, while tRNA-derived sRNAs (tsRNAs) had the tendency to be up-regulated, under drought. Antisense sRNAs (putative siRNAs) did not have such a tendency under drought. In drought-tolerant transgenic barley overexpressing DREB transcription factor, most of the low-expressed miRNAs were also down-regulated. In contrast, tsRNAs, rasiRNAs and other classes of sRNAs were not consistently expressed between the drought-treated and transgenic plants. The differential expression of miRNAs and siRNAs was further confirmed by Northern hybridization and quantitative real-time PCR (qRT-PCR). Targets of the drought-regulated miRNAs and siRNAs were predicted, identified by degradome libraries and confirmed by qRT-PCR. Their functions are diverse, but most are involved in transcriptional regulation. Our data provide insight into the expression profiles of miRNAs and other sRNAs, and their relationship under drought, thereby helping understand how miRNAs and sRNAs respond to drought stress in cereal crops.
Spectroscopic Properties of Void Galaxies in the Sloan Digital Sky Survey (2005)

We study the spectroscopic properties of a sample of 10^3 void galaxies from the Sloan Digital Sky Survey (SDSS) and compare these with the properties of galaxies in higher density regions (wall galaxies). This sample of void galaxies covers the range of absolute magnitude from M_r=-13.5 to M_r=-22.5 in regions with density contrast delta < -0.6. In this paper we compare the equivalent widths of Halpha, [OII], [NII], Hbeta, and [OIII] of void and wall galaxies of similar luminosities and find that void galaxies have larger values, indicating that they are still forming stars at a high rate. A comparison of the Balmer break, as measured by the parameter Dn(4000), reveals that void galaxies have younger stellar populations than wall galaxies. Using standard techniques, we estimate Halpha and [OII] star formation rates of the void and wall galaxies and along with estimates of the stellar masses, we compute specific star formation rates. In most cases, we find that void galaxies have similar SFRs to wall galaxies but they are fainter and smaller mass. This means that, consistent with the EWs, void galaxies have higher specific star formation rates than wall galaxies.
Current and future applications of virtual reality for medicine (1998)

Virtual reality is just emerging as an accepted scientific discipline for medicine. The majority of near-term applications are in the area of surgical planning, interoperative navigation, and surgical simulations. Its use in rehabilitative medicine and psychiatry has made significant progress. The immediate future holds promise for virtual endoscopy, which may replace standard endoscopic procedures for diagnostic screening. Viewing of these virtual images may be with head-mounted displays or true suspended holograms. The most highly developed area is in surgical simulations. Current generations are approaching photorealistic representation of the anatomy, while measurement science is providing physical tissue properties and physiologic parameters. The types of simulations range from "needle-based" procedures, such as standard intravenous insertion, central venous placement catheter, and chest-tube insertion to more sophisticated simulations of full surgical procedures like laparoscopic cholecystectomy or hysteroscopic resection of interuterine myoma. In addition, haptic input devices are providing the sense of touch to the procedures. Soon there will be patient-specific models derived from computed tomography or magnetic resonance imaging scans that will permit a surgeon to practice a delicate surgical procedure on the patient's specific virtual anatomy before actually performing the procedure on the patient.
Nitric oxide is released in regenerating liver after partial hepatectomy (1995)

The induction of hepatic nitric oxide synthase (NOS) and the biosynthesis of nitric oxide (NO) were studied in liver after partial hepatectomy (PH). NOS activity in the liver remnant was observed 4 to 6 hours after PH, and no differences were evidenced between the proximal and distal surgical areas. The form of NOS expressed in liver was independent of calcium and calmodulin, and the messenger RNA levels were first detected 2 hours after hepatectomy using a probe corresponding to the cytokine-induced macrophage NOS. The seric concentration of nitrites remained unchanged after hepatectomy, whereas the content in nitrates and in S-nitrosylated proteins progressively increased in parallel with the NOS activity. The spectra of hemoglobin in the 400-to 460-nm region failed to exhibit the characteristic shift caused by the formation of the nitrosyl-hemoglobin complex, suggesting that NO was rapidly metabolized in liver. Treatment of the animals with substrate analogue NOS inhibitors blocked the pattern of DNA ploidy elicited after hepatectomy, suggesting a role for NO in the regenerative process. Peritoneal resident macrophages were used as an alternative reporter cell system for the assessment of NOS expression. Incubation ex vivo of peritoneal macrophages from animals that underwent hepatectomy induced the expression of NOS in a cytokine-modulated fashion, suggesting that macrophages were primed as a result of the hepatectomy. When peritoneal macrophages from control rats were incubated with the sera of animals that underwent hepatectomy, a time-dependent induction of NOS was observed, with a maximal induction corresponding to sera collected 2 hours after PH. These results indicate that NO might be involved in the control of early responses after PH.
O-Band QPSK modulation based on a silicon dual-drive Mach-Zehnder (2018)

International audience
Reduction of dislocation density in epitaxial GaN layers by overgrowth of defect-related etch pits (2009)

GaN templates grown by the metal organic chemical vapor deposition method were etched in a defect-selective molten salts eutectic and were subsequently overgrown by a GaN layer using the hydride vapor phase epitaxy (HVPE) method. Optimized conditions of etching and of HVPE growth processes resulted in a significant reduction of the dislocations density (DD). Local areas virtually free of dislocations were obtained on ∼50% of the surface, while the average DD was reduced from 3×109 cm−2 in the template to about 2×107 cm−2 in the HVPE-grown GaN layer. A model has been developed to explain the mechanism of reduction of the DD during the overgrowth process. The model was confirmed by the photoetching of cleaved layers.
NAT Behavioral Requirements for Unicast TCP (2006)

This document defines a set of requirements for NATs that handle TCP
that would allow many applications, such as peer-to-peer applications
and on-line games, to work consistently. Developing NATs that meet
this set of requirements will greatly increase the likelihood that
these applications will function properly.
Melatonin and Immune Function: Hype or Hypothesis? (2002)

Outside of the tropics, the combined challenge of food shortage and low temperature makes winter a particularly difficult time for reproduction and survival. Traditionally, vertebrate physiologists interested in seasonal phenomena have focused on reproduction and largely ignored survival. Our goal is to emphasize a new dimension to the study of seasonality by shifting the focus from reproduction to immune function and survival. Our hypothesis is that mechanisms enhancing immune function have evolved that enable individuals to anticipate predictable seasonal challenges that may adversely affect immunity. Stated differently, we visualize seasonal variations in survival as the interaction between two factors: the suppression of immune response due to changing energetic conditions and an endogenous rhythm of enhancement of immune response that is dependent on photoperiod, clocks, and melatonin. In this article, we review evidence of photoperiod influences on seasonal changes in immune function within the context of energy allocation. Further, we also examine mounting evidence that the pattern of melatonin secretion, mediated by photoperiod, directly influences immune function.
Does topic metadata help with Web search? (2007)

Abstract It has been claimed that topic metadata can be used to improve the accuracy of text searches. Here, we test this claim by examining the contribution of metadata to effective searching within Web sites published by a university with a strong commitment to and substantial investment in metadata. The authors use four sets of queries, a total of 463, extracted from the university's official query logs and from the university's site map. The results are clear: The available metadata is of little value in ranking answers to those queries. A follow‐up experiment with the Web sites published in a particular government jurisdiction confirms that this conclusion is not specific to the particular university. Examination of the metadata present at the university reveals that, in addition to implementation deficiencies, there are inherent problems in trying to use subject and description metadata to enhance the searchability of Web sites. Our experiments show that link anchor text, which can be regarded as metadata created by others, is much more effective in identifying best answers to queries than other textual evidence. Furthermore, query‐independent evidence such as link counts and uniform resource locator (URL) length, unlike subject and description metadata, can substantially improve baseline performance.
LunaR: Overview of a versatile Raman spectrometer for lunar exploration (2022)

The LunaR concept study investigated the scientific value, feasibility, and deployment options for a Raman spectrometer on future lunar landed missions. It consists of a breadboard instrument that covers the 150–4000 cm −1 wavelength range with a resolution of ∼6 cm −1 ; Raman scattering is induced by a 532 nm continuous wave laser. The current conceptual design envisions the Raman spectrometer performing a downward-looking, 90-point one-dimensional across-track scan (±45°off nadir) of the lunar surface with the instrument mounted on the underside of a rover. A downward-looking context camera would provide information on the physical nature of targets interrogated by the Raman spectrometer and localization of the Raman spectra. Our laboratory investigations indicate that Raman spectroscopy is applicable to addressing a wide range of lunar surface exploration goals related to geology, in situ resource identification, and condensed volatile detection in diverse geological terrains, including permanently shadowed regions. Testing of a breadboard and commercial instrument on lunar samples and analogues indicates that a complete spectral scan of a target of interest can be completed in ∼90 min, permitting its use on even short-duration lunar landed missions. All of the major minerals present on the Moon can be detected, and in many cases their compositions can be quantified or constrained.
Quality Assurance For Image Display Devices In A Hospital-Wide IMACS Network (1989)

The AT&amp;T CommView® image management and communication system (IMACS) at Georgetown University supports multiple work stations for diagnosis, review, and research. Consistancy of the perceived brightness of displayed images throughout the network in the hospital is a critical issue. A simple method has been developed to set and track the brightness of cathod ray tuned used to display radiological images. A computer generated test image (SMPTE) is used. This consists of 11 brightness patches equally spaced over the dynamic range of CRT intensity driving levels. This test image is displayed and viewed in the same manner as patient images. An inexpensive hand-held photometer calibrated in ft-Lamberts is used to measure the brightness patches of the test images.
Clinical Efficiency of Non-Contact Infrared Thermometer over Axillary Digital Thermometer and Mercury in Glass Thermometer with Paracetamol (2021)

Fever is defined as rise in normal body temperature above 98.6°F. Clinical thermometer is a medical instrument for measuring human body temperature. The traditionally used mercury in glass thermometer was replaced by digital thermometer due to mercury toxicity. Non-contact infra-red thermometer is a non-invasive thermometer used for un-cooperative pediatric patients. The objective of this study is to determine the clinical efficiency of non-contact infrared thermometer over axillary digital thermometer and mercury in glass thermometer over a range of body temperature by using paracetamol in febrile patients. This descriptive hospital based cross sectional study was conducted from 5th December 2019 till 23rd August 2020 after ethical approval from Institutional Review Committee of Nepal Medical College and Teaching Hospital. Mercury in glass thermometer, axillary digital thermometer and non-contact infrared thermometer were used to measure body temperature in febrile patient. Body temperature was re-measured one hour after administration of paracetamol. Data was entered and analyzed with statistical package for social sciences version 16. Axillary digital thermometer has high predictability in the upper body temperature range (in febrile state) but its predictability is low in lower body temperature range (our normal body temperature). Non-contact infrared thermometer in comparison with axillary digital thermometer has lower predictability in both upper and lower body temperature range. Clinical efficiency of non-contact infrared thermometer is less than that of axillary digital thermometer and mercury in glass thermometer in febrile patients.
MinHash hierarchy for privacy preserving trajectory sensing and query (2017)

In this work, we study privacy preserving trajectory sensing and query when n mobile entities (e.g., mobile devices or vehicles) move in an environment of m checkpoints (e.g, WiFi or cellular towers). The checkpoints detect the appearances of mobile entities in the proximity, meanwhile, employ the MinHash signatures to record the set of mobile entities passing by. We build on the checkpoints a distributed data structure named the MinHash hierarchy, with which one can efficiently answer queries regarding popular paths and other traffic patterns. The MinHash hierarchy has a total of near linear storage, linear construction cost, and logarithmic update cost. The cost of a popular path query is logarithmic in the number of checkpoints. Further, the MinHash signature provides privacy protection using a model inspired by the differential privacy model. We evaluated our algorithm using a large mobility data set and compared with previous works to demonstrate its utilities and performances.
Multidimensional localization of multiple sound sources using averaged directivity patterns of Blind Source Separation systems (2009)

In this paper, we propose a versatile acoustic source localization framework exploiting the self-steering capability of Blind Source Separation (BSS) algorithms. We provide a way to produce an acoustical map of the scene by computing the averaged directivity pattern of BSS demixing systems. Since BSS explicitly accounts for multiple sources in its signal propagation model, several simultaneously active sound sources can be located using this method. Moreover, the framework is suitable to any microphone array geometry, which allows application for multiple dimensions, in the near field as well as in the far field. Experiments demonstrate the efficiency of the proposed scheme in a reverberant environment for the localization of speech sources.
Signals from chloroplasts converge to regulate nuclear gene expression. (2007)

Plastid-to-nucleus retrograde signaling coordinates nuclear gene expression with chloroplast function and is essential for the photoautotrophic life-style of plants. Three retrograde signals have been described, but little is known of their signaling pathways. We show here that GUN1, a chloroplast-localized pentatricopeptide-repeat protein, and ABI4, an Apetala 2 (AP2)–type transcription factor, are common to all three pathways. ABI4 binds the promoter of a retrograde-regulated gene through a conserved motif found in close proximity to a light-regulatory element. We propose a model in which multiple indicators of aberrant plastid function in <i>Arabidopsis</i> are integrated upstream of GUN1 within plastids, which leads to ABI4-mediated repression of nuclear-encoded genes.
p21WAF1/CIP1 antisense therapy radiosensitizes human colon cancer by converting growth arrest to apoptosis. (2000)

Substantial evidence suggests that loss of cellular p21WAF1/CIP1 results in increased apoptotic killing by ionizing radiation. We hypothesized that a p21 antisense (AS) oligodeoxynucleotide (ODN) could be used to sensitize cancer cells to radiotherapy. In vitro treatment of colon cancer cells (HCT116/p21+/+) with p21 AS ODN (200 nM) led to inhibition of radiation-induced p21 expression (>95% inhibition, 0-30 Gy), resulting in a loss of G1 arrest and an enhancement of apoptosis to comparable levels and with similar kinetics to HCT116/p21-/- cells (approximately 60% apoptotic cells at 96 h after 10 Gy). In vivo, p21 AS ODN in combination with radiation (i.p. ODN for 6 days at 20 mg/kg/day and 15 Gy) increased apoptosis in s.c. p21+/+ tumors in nude mice to levels similar to those of p21-/- tumors (2-fold at 24 h postirradiation) and improved radiocurability of p21+/+ tumors to levels comparable to those of p21-/- tumors (p21+/+, two of eight cures versus p21-/-, two of nine cures). Our findings suggest that p21 AS treatment may be a rational approach to improve conventional radiotherapy outcomes.
Live Database Migration for Elasticity in a Multitenant Database for Cloud Platforms (2010)

The growing popularity of cloud computing as a platform for deploying internet scale applications has seen a large number of web applications being deployed in the cloud. These applications (or tenants) are typically characterized by small data footprints, different schemas, and variable load patterns. Scalable multitenant database management systems (DBMS) running on a cluster of commodity servers are thus critical for a cloud service provider to support a large number of small applications. Multitenant DBMSs often collocate multiple tenants ’ databases on a single server for effective resource sharing. Due to the variability in load, elastic load balancing of tenants ’ data is critical for performance and cost minimization. On demand migration of tenants ’ databases to distribute load on an elastic cluster of machines is a critical technology for elastic load balancing. Therefore, efficient live database
Extrinsic Fabry–Perot interferometer vibration and acoustic sensor systems for airport ground traffic monitoring (1997)

The authors describe new fibre optic vibrational and acoustic sensor systems developed for airport ground traffic monitoring. The theoretical background of the extrinsic Fabry–Perot interferometer (EFPI) sensors is derived, and results of laboratory experiments as well as initial field tests in an experimental surface movement guidance and control system (ESMGCS) at the Braunschweig airport are reported.