gebhart/patrepeval huggingface dataset:
Laminoplasty with selective fusion at unstable segment versus laminectomy with fusion for multilevel cervical myelopathy: A retrospective comparative study (2019)

Abstract Purpose The aim of this study was to compare laminoplasty with selective fixation (LPSF) versus laminectomy with fusion (LCF) in patients with multilevel cervical myelopathy accompanied by segmental instability.Methods A retrospective cohort study was conducted by reviewing data from 63 patients who underwent LPSF (n=30) or LCF (n=33). Cervical alignment, range of motion (ROM), neurologic status and axial symptom severity pre-operation, 3-days after operation, and at the final follow-up (minimum 24 months) were measured and compared between groups.Results Postoperation, patients in the LPSF group lost 31.1±17.3% of cervical lordosis and 43.2±10.9% cervical ROM while patients in the LCF group lost 5.7±8.2% and 67.9±15.5%, respectively. Both LPSF and LCF groups significantly improved neurologic status and axial symptom severity at the final follow-up with similar between-group results(P&gt;0.05). Blood loss, operation time, hospital stay, and medical cost in the LPSF group were significantly less than in the LCF group(P&lt;0.05). The incidence of negative events were statistically similar between groups.Conclusion According to our results, LPSF was effective in maintaining the stability of the cervical spine with less sacrifice of mobility and surgical trauma for multilevel myelopathy with segmental instability compared to LCF.
Authorizing Card Payments with PINs (2008)

Chip and PIN technology was introduced as a means of decreasing payment-card fraud. However, according to results of a two-phase experiment, the technology makes it easier for thieves to obtain PINs and more difficult for customers to defend against counterfeiting.
SAR image segmentation based on Gabor filters of adaptive window in overcomplete brushlet domain (2009)

In this paper, a new technique based on Gabor filters with adaptive window is proposed for SAR image segmentation in overcomplete brushlet domain. SAR image is full of texture and direction information, and brushlet is a new kind of analysis tool for image with rich directional information. Aim at these characteristics, this paper combines Gabor filters with GLCP for segmentation in brushlet coefficients domain. In SAR image processing, the difficulty is the balance between regions and boundaries. The adaptive window technique is adapted in this paper to obtain the optimal size of Gabor filters. The presented method was found to be superior to three other methods by the experimental results for SAR image.
Bacterial Secretions of Nonpathogenic Escherichia coli Elicit Inflammatory Pathways: a Closer Investigation of Interkingdom Signaling (2015)

The symbiotic relationship between the microbiome and the host is important in the maintenance of human health. There is a growing need to further understand the nature of these relationships to aid in the development of homeostatic probiotics and also in the design of novel antimicrobial therapeutics. To our knowledge, this is the first global-transcriptome study of bacteria cocultured with human epithelial cells in a model to determine the transcriptional effects of epithelial cells in which epithelial and bacterial cells are allowed to "communicate" with each other only through diffusible small molecules and proteins. By beginning to demarcate the direct and indirect effects of bacteria on the gastrointestinal (GI) tract, two-way interkingdom communication can potentially be mediated between host and microbe.
Bioanalytical Application of the Ordered Mesoporous Carbon Modified Electrodes (2008)

Abstract An ordered mesoporous carbon modified electrode (OMCE) was prepared by film forming method. The electrochemical behavior of the OMCE was evaluated in connection with the electrochemistry of some electroactive biospecies, such as ascorbic acid (AA), acetaminophenol (AP), cysteine (CySH), dopamine (DA), epinephrine (EP), uric acid (UA), β‐nicotinamide adenine dinucleotide (reduced disodium salt hydrate, NADH), and hydrogen peroxide (H 2 O 2 ) with cyclic voltammetry. Compared with the conventional carbon nanotubes (CNT) and graphite powder (GP) modified electrodes, the OMCE provided the best electrochemical reactivities in all cases associated with decreased over potential, better‐defined peak shape, and higher sensitivity. In addition, the OMC, CNT, and GP modified electrodes were employed as sensitive sensors for H 2 O 2 and NADH quantification and as stable platforms for the fabrication of glucose and ethanol biosensors on which the enzymes were immobilized.
Phase I trial with pharmacokinetic analyses of high-dose carboplatin, etoposide, and cyclophosphamide with autologous bone marrow transplantation in patients with refractory germ cell tumors. (1993)

Thirty patients with cisplatin-refractory germ cell tumor were treated with high-dose carboplatin, etoposide, and cyclophosphamide and autologous bone marrow transplantation. The total dose of carboplatin was 1500 mg/m2, etoposide 1200 mg/m2, and cyclophosphamide was increased by increments from 60 to 150 mg/kg. Twenty-five cycles of treatment, given to 17 patients, did not include granulocyte-colony stimulating factor (G-CSF). Nineteen cycles of high-dose chemotherapy, given to 13 patients at the 2 highest dose levels of cyclophosphamide, included G-CSF. The dose of cyclophosphamide was escalated to 150 mg/kg/cycle without prohibitive toxicity. The use of G-CSF resulted in a shorter duration of neutropenia (P = 0.07); the median number of days until the recovery of an absolute granulocyte count > 0.5 was 25 without G-CSF and 14 with G-CSF. The most frequent nonhematological toxicity was hepatic, and there were 2 (7%) treatment-related deaths. Thirteen (43%) patients achieved a complete response, and 8 are alive and free of disease (27%); 7 are in continuous complete response (23%), and 1 after resection of a solitary site of disease following a relapse after high-dose chemotherapy. Five patients had pharmacology studies performed to determine the area under the curve (AUC) of free and total platinum, carboplatin, etoposide, cyclophosphamide, and phosphoramide mustard. There was a decrease in the AUC of cyclophosphamide and an increase in the AUC of phosphoramide mustard, the "active" metabolite, with successive days of treatment. The interpatient variability of the AUC of cyclophosphamide/phosphoramide mustard that was demonstrated was most likely a result of each individual's metabolic capacity. The measured AUC of carboplatin and/or free platinum closely approximated the predicted AUC of carboplatin calculated by renal function in 3 of the 5 patients. In summary, cyclophosphamide administered at a dose of 50 mg/kg x 3 days was achieved with acceptable toxicity, and no further dose escalation is planned. High-dose carboplatin, etoposide, and cyclophosphamide achieved a 23% continuous complete response proportion (27% alive, free of disease) when used as third-line therapy in germ cell tumor patients refractory to cisplatin + ifosfamide-based chemotherapy. Ongoing studies are addressing the role of high-dose carboplatin-containing chemotherapy in previously untreated patients with poor prognostic features or as a part of first-line salvage.
Nanomaterials for Ocular Drug Delivery (2012)

Efficient drug delivery to the eye remains a challenging task for pharmaceutical scientists. Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye, conventional drug delivery systems, such as eye drop solutions, suffer from low bioavailability. More invasive methods, such as intravitreal injections and implants, cause adverse effects in the eye. Recently, an increasing number of scientists have turned to nanomaterial-based drug delivery systems to address the challenges faced by conventional methods. This paper highlights recent applications of various nanomaterials, such as polymeric micelles, hydrogels, liposomes, niosomes, dendrimers, and cyclodextrins as ocular drug delivery systems to enhance the bioavailability of ocular therapeutic agents.
Artificial Intelligence (2019)

Abstract In this chapter, we provide an overview of different artificial intelligence (AI) and machine learning (ML) techniques and discuss how these techniques have been employed in managing geospatial data sets as they pertain to Digital Earth. We introduce statistical ML methods that are frequently used in spatial problems and their applications. We discuss generative models, one of the hottest topics in ML, to illustrate the possibility of generating new data sets that can be used to train data analysis methods or to create new possibilities for Digital Earth such as virtual reality or augmented reality. We finish the chapter with a discussion of deep learning methods that have high predictive power and have shown great promise in data analysis of geospatial data sets provided by Digital Earth.
Proton NMR spectroscopy as a novel approach of coldischemia in a perfuded isolated kidney model. (1997)

International audience
Ab initio calculations on Li-ion migration in Li2FeSiO4 cathode material with a P21 symmetry structure (2011)

We have systematically investigated the diffusion mechanism of Li ions in Li2FeSiO4 and its delithiated product LiFeSiO4 based on the P21 symmetry using the first principle method. Calculations on the energy barriers for possible spatial hopping pathways predicted that the activation barriers along the [101] direction and Li ion layer in the ac plane are relatively low, which can ensure the facile lithium diffusion along those directions. The results indicate that Li2FeSiO4 with the P21 symmetry is an ionic conductor for Li ions with two-dimensional diffusion.
A Computational and Experimental Approach Linking Disorder, High‐Pressure Behavior, and Mechanical Properties in UiO Frameworks (2016)

Abstract Whilst many metal–organic frameworks possess the chemical stability needed to be used as functional materials, they often lack the physical strength required for industrial applications. Herein, we have investigated the mechanical properties of two UiO‐topology Zr‐MOFs, the planar UiO‐67 ([Zr 6 O 4 (OH) 4 (bpdc) 6 ], bpdc: 4,4′‐biphenyl dicarboxylate) and UiO‐abdc ([Zr 6 O 4 (OH) 4 (abdc) 6 ], abdc: 4,4′‐azobenzene dicarboxylate) by single‐crystal nanoindentation, high‐pressure X‐ray diffraction, density functional theory calculations, and first‐principles molecular dynamics. On increasing pressure, both UiO‐67 and UiO‐abdc were found to be incompressible when filled with methanol molecules within a diamond anvil cell. Stabilization in both cases is attributed to dynamical linker disorder. The diazo‐linker of UiO‐abdc possesses local site disorder, which, in conjunction with its longer nature, also decreases the capacity of the framework to compress and stabilizes it against direct compression, compared to UiO‐67, characterized by a large elastic modulus. The use of non‐linear linkers in the synthesis of UiO‐MOFs therefore creates MOFs that have more rigid mechanical properties over a larger pressure range.
MLS, a magnetic logic simulator for magnetic bubble logic design (1987)

A computer program that simulates the logic functions of magnetic bubble devices has been developed. The program uses a color graphics screen to display the locations of bubbles on a chip during operation. It complements the simulator previously developed for modeling bubble devices on the gate level [Smith et al., IEEE Trans. Magn. MAG-19, 1835 (1983); Smith and Kryder, ibid. MAG-21, 1779 (1985)]. This new tool simplifies the design and testing of bubble logic devices, and facilitates the development of complicated LSI bubble circuits. The program operation is demonstrated with the design of an in-stream faulty loop compensator using bubble logic.
Waveform optimization for radio-frequency wireless power transfer : (Invited paper) (2017)

In this paper, we study the waveform design problem for a single-input single-output (SISO) radio-frequency (RF) wireless power transfer (WPT) system in frequency-selective channels. First, based on the actual non-linear current-voltage model of the diode at the energy receiver, we derive a semi-closed-form expression for the deliverable DC voltage in terms of the incident RF signal and hence obtain the average harvested power. Next, by adopting a multisine waveform structure for the transmit signal of the energy transmitter, we jointly design the multisine signal amplitudes and phases over all frequency tones according to the channel state information (CSI) to maximize the deliverable DC voltage or harvested power. Although our formulated problem is non-convex and difficult to solve, we propose two suboptimal solutions to it, based on the frequency-domain maximal ratio transmission (MRT) principle and the sequential convex optimization (SCP) technique, respectively. Using various simulations, the performance gain of our solutions over the existing waveform designs is shown.
Identification of HLA‐A2 restricted CD8+ T‐lymphocyte responses to Plasmodium vivax circumsporozoite protein in individuals naturally exposed to malaria (2002)

Specific CD8(-) T-lymphocyte (CTL) activity against Plasmodium pre-erythrocytic stages (P-ES) derived antigens is considered one of the most important mechanisms for malaria protection. Plasmodium vivax is the second most prevalent human malaria parasite species distributed worldwide. Although several CTL epitopes have been identified in Plasmodium falciparum P-ES derived antigens, none has been described for P. vivax to date. In this study, we analysed HLA-A*0201 specific CD8(-) T-lymphocyte responses to the P. vivax circumsporozoite (CS) protein in both malaria exposed and non-exposed populations from the Colombian Pacific Coast. First, we analysed the prevalence of HLA-A2 allele in the study populations and found that approximately 38 of the individuals expressed this molecule and that 50 of them were HLA-A*0201. We then selected, on the P. vivax CS, five peptide sequences containing the HLA-A*0201 binding motifs and used the corresponding synthetic peptides to evaluate the CD8(-) T-lymphocyte interferon (IFN)-gamma response. Peripheral blood mononuclear cells from the HLA-A*0201 donors were in vitro stimulated with these peptides and IFN-gamma production was determined by an ELISPOT assay. Specific CD8(-) T-lymphocyte responses were detected for three peptides located in the C-terminal region of the protein. Specific responses to these peptides were also detected in several individuals expressing different HLA-A*02 subtypes. The potential of these peptides to induce specific cytolysis and that of long synthetic peptides comprising these epitopes as P. vivax malaria vaccine subunits are being studied.
Polarity of amber mutations in ribosomal protein genes of Escherichia coli (1980)

Two amber mutations have been mapped inside the spcA-strA region (now called rpsE-rpsL) on the bacterial genome. Derivatives of the transducing phage lambda fus3 carrying each mutation were constructed and assayed in ultraviolet-irradiated bacteria to identify the mutated genes and measure the polarity of the mutations. The data indicated that both mutations, 3162(Am) and 3161(Am), affect genes coding for ribosomal proteins: rplC (L3) and rpsN (S14), respectively. It was shown also that each mutation exerts, inside of its respective operon (S10 and spc units), a relatively strong polar effect on genes distal to the mutated locus.
The effect of norepinephrine on the incidence of stress-induced gastric erosions. (1989)

The number of gastric erosions induced experimentally by immobilization stress were observed following norepinephrine treatment. We revealed a significant reduction of the number of erosions. This indicates the protective effect of sympathetic nervous system in the pathogenesis of stress-induced erosions.
Corrosion Behaviour of Fe-based and Ni-based Alloys in Wet CO2 Gas with and without Chloride Deposits at 750°C (2023)

Abstract Corrosion behaviours of Fe-25Cr, Fe-25Cr-2Mn-1Si, Fe-25Cr-20Ni, 310SS, Ni-25Cr, and Ni-25Cr-2Mn-1Si (all in wt. %) with and without NaCl-KCl deposits in Ar-60%CO 2 -20%H 2 O gas at 750 o C were studied. Without salt deposits, Fe-25Cr performed protectively, while Fe-25Cr-20Ni and Ni-25Cr underwent breakaway oxidation with multi-layered scales formed. Adding alloy elements Si + Mn increased the corrosion resistance of all alloys by forming additional Mn-rich oxides and silica. Surface deposits of NaCl-KCl accelerated corrosion, forming porous Fe-rich oxide nodules for Fe-25Cr and thick, porous scales and internal oxidation zones for all other alloys. The protective effect of Si + Mn alloying disappeared in the presence of chlorides. Limited intergranular carbides were observed for all alloys in the gas-only condition. The extent of carburisation increased with the presence of chloride deposits for all Fe-based alloys, but remained unchanged for Ni-based alloys. Corrosion of these alloys at 750 o C is compared with that at 650 o C. The effect of chlorides in volatilising metals at 750 o C is discussed.
A New, Efficient and Stereoselective Synthesis of Tricyclic and Tetracyclic Compounds by Samarium Diiodide Induced Cyclizations of Naphthyl‐Substituted Arylketones — An Easy Access to Steroid‐Like Skeletons. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cancer du côlon MSI : faut-il un traitement adjuvant ? (2012)

Le phenotype microsatellites instables (MSI) est trouve dans environ 15 % des cancers colorectaux et peut etre d’origine sporadique ou hereditaire. Plusieurs etudes ont montre que les patients avec une tumeur MSI avaient un meilleur pronostic que les patients avec une tumeur a microsatellites stables. Les donnees cliniques les plus recentes indiquent que les patients avec une tumeur MSI de forme hereditaire traites par 5-fluorouracile (5-FU) en situation adjuvante pourraient avoir un gain de survie, contrairement aux formes sporadiques qui n’en beneficieraient pas. En revanche, il n’existe que peu de donnees concernant le traitement adjuvant par FOLFOX. Certaines donnees preliminaires issues d’etudes retrospectives suggerent que l’adjonction d’oxaliplatine au 5-FU pourrait apporter un gain de survie pour les patients MSI de stade III. Toutefois, ces resultats devront etre confirmes par l’analyse en cours des echantillons tumoraux provenant des essais randomises anterieurement publies comparant le 5-FU au FOLFOX (etudes MOSAIC et NSABP-C07).
Radiatively coupled corrugated waveguides (1994)

Spectral investigation of the radiation emitted by
Conformational analysis of 14‐hydroxymodhephene by NMR, x‐ray diffraction and molecular modeling studies (2003)

Abstract The conformational state of the [3.3.3]propellane framework for 14‐hydroxymodhephene was determined by extensive application of one‐ and two‐dimensional 1 H and 13 C NMR spectroscopy combined with x‐ray diffraction studies of a synthesized derivative, spectral simulation and molecular modeling. The conformational rigidity of the molecule in solution, established at room temperature, revealed the existence of envelope conformers for both cyclopentane fragments, with C‐7 puckered endo and C‐10 exo with respect to the mean plane containing the B and C rings. Copyright © 2003 John Wiley &amp; Sons, Ltd.
One Glass Single ITO Layer Solution for Large Size Projected-Capacitive Touch Panels (2015)

One glass single ITO layer solution has been demonstrated for large size projected-capacitive touch panels. Using simple touch sensors and algorithm, the proposed solution can effectively solve the issues of sensitivity reduction and large coordinate shifting existing in current large size touch panels. A touch system based on the proposed solution can achieve a coordinate shifting of less than 1.5%.
Spontaneous Spectral Diffusion in CdSe Quantum Dots (2012)

Spectral diffusion of the emission line of single colloidal nanocrystals is generally regarded as a random process. Here, we show that each new spectral position has a finite memory of previous spectral positions, as evidenced by persistent anticorrelations in time series of spectral jumps. The anticorrelation indicates that there is an enhanced probability of the charge distribution around the nanocrystal returning to a previous configuration. We show both statistically and directly that this memory manifests as an observable spontaneous "relaxation" in the absence of a pump laser, so that spectral diffusion progresses in a manner of "two steps forward and one step back".
SoRC - Evaluation of Computational Molecular Co-Localization Analysis in Mass Spectrometry Images (2020)

The computational analysis of Mass Spectrometry Imaging (MSI) data aims at the identification of interesting mass co-localizations and the visualization of their lateral distribution in the sample, usually a tissue cross section. But as the morphological structure of tissues and the different kinds of mass co-localization naturally show a huge diversity, the selection and tuning of the computational method is a time-consuming effort. In this work we address the special problem of computationally grouping mass channel images according to their similarities in their lateral distribution patterns. Such an analysis is driven by the idea, that groups of molecules that feature a similar distribution pattern may have a functional relation. But the selection of the similarity function and other parameters is often done by a time-consuming and unsatsifactory trial and error. We propose a new flexible workflow scheme called SoRC (sum of ranked cluster indices) for automating this tuning step and making it much more efficient. We test SoRC using three different data sets acquired from the lab for three different kinds of samples (barley seed, mouse bladder tissue, human PXE skin). We show, that SORC can be applied to score and visualize the results obtained with the applied methods in short time without too much effort. In our application example, the SoRC results for the three data sets reveal that a) some well-known similarity functions are suited to achieve good results for all three data sets and b) for the MSI data featuring a higher degree of irregularity improved results can be achieved by applying non-standard similarity functions. The SoRC scores computed with our approach indicate that an automated testing and scoring of different methods for mass channel image grouping can improve the final outcome of a study by finally selecting the methods of the highest scores.
The epigenetic landscape: An evolving concept (2023)

The epigenetic landscape was a visual metaphor introduced in the mid-twentieth century to illustrate the genetic control of embryonic differentiation. Although the popular understanding of epigenetics has since expanded to include gene and chromosomal mechanisms in all contexts, the landscape metaphor provides a unifying concept centered around processes that establish and maintain cellular memory. However, over the decades the term epigenetics has been also used to describe some non-genetic processes that bear little or no resemblance to the traditional concept of an epigenetic landscape. By establishing Frontiers in Epigenetics and Epigenomics , we aim to provide authors and readers a forum and an outlet for research that is centered around the original concept of an epigenetic landscape. Thanks in large part to exciting advances in epigenomic technologies, we expect that a deeper understanding of cellular memory will translate into new strategies for medicine, agriculture, and environmental health.