gebhart/patrepeval huggingface dataset:
A genetic linkage map for the ectomycorrhizal fungus Laccaria bicolor and its alignment to the whole‐genome sequence assemblies (2008)

A genetic linkage map for the ectomycorrhizal basidiomycete Laccaria bicolor was constructed from 45 sib-homokaryotic haploid mycelial lines derived from the parental S238N strain progeny. For map construction, 294 simple sequence repeats (SSRs), single-nucleotide polymorphisms (SNPs), amplified fragment length polymorphisms (AFLPs) and random amplified polymorphic DNA (RAPD) markers were employed to identify and assay loci that segregated in backcross configuration. Using SNP, RAPD and SSR sequences, the L. bicolor whole-genome sequence (WGS) assemblies were aligned onto the linkage groups. A total of 37.36 Mbp of the assembled sequences was aligned to 13 linkage groups. Most mapped genetic markers used in alignment were colinear with the sequence assemblies, indicating that both the genetic map and sequence assemblies achieved high fidelity. The resulting matrix of recombination rates between all pairs of loci was used to construct an integrated linkage map using JoinMap. The final map consisted of 13 linkage groups spanning 812 centiMorgans (cM) at an average distance of 2.76 cM between markers (range 1.9-17 cM). The WGS and the present linkage map represent an initial step towards the identification and cloning of quantitative trait loci associated with development and functioning of the ectomycorrhizal symbiosis.
X-reality for phantom limb management for amputees: A systematic review and meta-analysis (2023)

Phantom limb is a disabling neuropsychiatric condition among amputees resulting in pain and disturbance that impact their functions, quality of life, and autonomy. While pharmacological approaches appeared to be ineffective, the emergence and integration of X-reality, including virtual reality, augmented reality, and mixed reality, might elevate the effectiveness of mirror therapy in managing phantom limb. The objective of this study is to review X-reality for managing phantom pain. A systematic search was conducted on PubMed, Scopus, Web of Science, PsycINFO, Embase, and CINAHL. Sixteen (n = 16) studies containing 66 lower-limb and 53 upper-limb amputees were included for the review over the thematic framework of amputee characteristics and intervention designs, while thirteen (n = 13) studies were further proceeded for the meta-analysis. We found eleven studies on virtual reality (n = 11), four studies on marker-based augmented reality (n = 4) and one study on mixed reality (n = 1) with a total of 40 game/task themes involving, motor skills, motor control, and stimulus-sensing. Regardless, all these interventions adopted the movement representation strategies with different techniques. Overall, the X-reality interventions reduced the pain level of the amputees (mean difference: -2.30, 95% CI, -3.38 to -1.22), especially the virtual reality subgroup (mean difference: -2.83, 95% CI, -4.43 to -1.22). However, there were substantial heterogeneity and partially explained by the subgroup analysis on publication year. The strength of evidence was limited by case reports and case series in this review.
Generation of Automated Sports Commentary from Live Sports Data (2019)

We have developed a method of generating “automated sports commentary” that conveys an objective situation with synthesized speech based on live sports data. Our method can be applied to a wide variety of sports events by preparing “commentary templates” for each of them. The results of a subjective assessment demonstrated that the automated sports commentary generated with our method is effective for helping listeners understand the game situation. In addition, a public live streaming with the automated commentary showed that our proposed method can provide practical service for live sports broadcasting.
Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation (2021)

Sleep deprivation is a form of stress that provokes both inflammatory responses and neuropsychiatric disorders. Because persistent inflammation is implicated as a physiological process in anxiety disorders, we investigated the contributions of NLRP3 inflammasome signaling to anxiety and anxiolytic properties of flavanol diets in a model of chronic sleep deprivation. The results show a flavanol-rich dietary preparation (FDP) exhibits anxiolytic properties by attenuating markers of neuroimmune activation, which included IL-1β upregulation, NLRP3 signaling, and microglia activation in the cortex and hippocampus of sleep-deprived mice. Production of IL-1β and NLRP3 were critical for both anxiety phenotypes and microglia activation. Individual FDP metabolites potently inhibited IL-1β production from microglia following stimulation with NLRP3-specific agonists, supporting anxiolytic properties of FDP observed in models of sleep deprivation involve inhibition of the NLRP3 inflammasome. The study further showed sleep deprivation alters the expression of the circadian gene Bmal1, which critically regulated NLRP3 expression and IL-1β production.
Lithography Based on Memory Effects Resulting from Photoinduced Self-Assembly of Pyrene Dimers in Thin Polymer Films (2009)

Pulsed laser irradiation of pyrene in thin films through lithographic masks leads to blue fluorescent images characteristic of pyrene excimer emission. The images are stable at room temperature and are readily observable using fluorescence microscopy. For a constant energy dose, the images are stronger and better resolved at the shorter laser wavelengths and cannot be recorded with continuous wavelength (CW) light sources. Images are easier to obtain with high Tg films, while polymers with Tg below room temperature image only when the laser also causes polymer cross-linking. It is proposed that laser excitation generates excited singlet pyrene and simultaneously causes a temperature change that facilitates diffusion and thus excimer formation. Following excited state (monomer and excimer) decay, the polymer matrix cools down and prevents the separation of the pyrene pairs, that are preserved by the rigid polymer matrix. Some of the images can be thermally erased by annealing above Tg. The method may find applications in imaging and information storage.
Catalytic asymmetric conjugate boration of α,β-unsaturated sulfones (2011)

The α,β-unsaturated sulfones are suitable activated olefins in catalytic asymmetric conjugate β-boration. These substrates undergo smooth conjugate addition of bis(pinacolato)diboron [B(2)(pin)(2)] catalyzed by nonracemic Cu(I)-diphosphine complexes to provide, upon subsequent oxidation, β-hydroxy sulfones in good yields and high enantiocontrol.
Wearable See-thru Binocular Simulator of Multifocal and Monovision Presbyopic Corrections (2017)

Presentación con 32 diapositivas. -- San Jose, California, United States of America, Feb 24 - 25, 2017
A 2.4-GHz 6.4-mW fractional-N inductorless RF synthesizer (2016)

A ring-oscillator-based cascaded synthesizer architecture incorporates a digital synchronous delay line and an analog noise trap to suppress the quantization noise of the ΣΔ modulator. Realized in 45-nm digital CMOS technology, the synthesizer exhibits an in-band phase noise of -109 dBc/Hz and an integrated jitter of 1.68 ps <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> .
Diagnostics and modeling of a pulsed microwave-excited discharge in oxygen (1999)

Investigations on a pulsed O<SUB>2</SUB> plasma under low pressure (1 - 10) mbar have been carried out. Microwave pulses (2.45 GHz) with a duration of (50 - 200) microsecond(s) and a repetition rate of (10 - 500) Hz are typical for the experiments. The electron density has been determined by means of an HCN laser interferometer. Detection of negative ions O<SUP>-</SUP> has been performed using a photodetachment technique with a Nd:YAG laser. A kinetic model predicting the temporal behavior of the densities of oxygen atoms and molecules, metastable singlets O<SUB>2</SUB>(a<SUP>1</SUP>(Delta) , b<SUP>1</SUP>(Sigma) ), negative ions O<SUP>-</SUP>, positive ions O<SUP>+</SUP><SUB>2</SUB>, ozone, and the electron density has been developed. The experimental and theoretical data are fond to agree well.
Malignant Mixed Mullerian Tumors of the Ovary (1993)

Long-term survival following the diagnosis of ovarian malignant mixed mullerian tumor (MMMT) is unusual. This report analyzes two such long-term survivors. One patient presented with a FIGO Stage III, homologous MMMT treated initially with a combination of surgery and chemotherapy. Residual disease, present at the time of initial operation, responded to the chemotherapy; however, the tumor recurred 2 1/2 years postoperatively. This recurrence responded to a combination of surgery and chemotherapy, including continuous adjuvant chemotherapy. This patient is alive, on maintenance chemotherapy, and without evidence of disease, approximately 7 years after the recurrence and 9 years after the initial presentation. The other patient presented with a FIGO Stage III heterologous MMMT treated initially with combined surgery and chemotherapy. Residual disease was present at the time of initial operation. Persistent pelvic disease led to exploratory laparotomy, excision of an 8-cm diameter pelvic mass, and postoperative radiation therapy. The tumor recurred in the left supraclavicular lymph nodes 2 years later (3 years after the initial presentation). This recurrence responded to radiation therapy. This patient was last seen 2 years later (5 years after the initial presentation). At that time, she was without evidence of recurrence. She died 7 1/2 years after her initial presentation. These two patients represent examples of the unusual occurrence of patients with advanced-stage ovarian MMMT experiencing long-term survival following surgical and adjuvant therapy.
Location of somatic and germline <i>ETV6</i> mutations and structural modeling. (2015)

&lt;p&gt;(a) Schematic depicting the germline &lt;i&gt;ETV6&lt;/i&gt; mutations detected in the MSKCC and SJCRH kindred, reported separately or somatic mutations detected as part of the Pediatric Cancer Genome Project. Somatic and germline mutations are indicated by separate green and purple lines, respectively. (b) Structural modeling of ETV6 with the germline &lt;i&gt;ETV6&lt;/i&gt; L349P and N385fs mutations. The &lt;i&gt;ETV6&lt;/i&gt; L349P amino acid substitution is located on an α-helix within the DNA binding domain and causes extensive kinking of the protein structure. The &lt;i&gt;ETV6&lt;/i&gt; N385fs mutation results in truncation of the DNA binding domain.&lt;/p&gt;
A Shared Population of Epidemic Methicillin-Resistant Staphylococcus aureus 15 Circulates in Humans and Companion Animals (2014)

Methicillin-resistant Staphylococcus aureus (MRSA) is major problem in human medicine. Companion animals, such as cats, dogs, and horses, can also become colonized and infected by MRSA. Here, we demonstrate that a shared population of an important and globally disseminated lineage of MRSA can infect both humans and companion animals without undergoing host adaptation. This suggests that companion animals might act as a reservoir for human infections. We also show that the isolates from companion animals have differences in the presence of certain antibiotic resistance genes. This study furthers the "one health" view of infectious diseases by demonstrating that the pool of MRSA isolates in the human and animal populations are shared and highlights how different antibiotic usage patterns between human and veterinary medicine can shape the population of bacterial pathogens.
Photochemical reactions of 2-pyrone and thermal reactions of the 2-pyrone photoproducts (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical reactions of 2-pyrone and thermal reactions of the 2-pyrone photoproductsWilliam H. Pirkle and L. H. McKendryCite this: J. Am. Chem. Soc. 1969, 91, 5, 1179–1186Publication Date (Print):February 1, 1969Publication History Published online1 May 2002Published inissue 1 February 1969https://doi.org/10.1021/ja01033a025Request reuse permissionsArticle Views803Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Key to Cheaper, Better Nanotubes Comes Out in the Wash (2004)

Since their discovery 13 years ago, carbon nanotubes have been nanotechnology's poster child. The tiny straw-shaped molecules are stronger than steel, flexible, and conductive. Researchers have pitched them as the right stuff for everything from chemical sensors and drug-delivery agents to wires for nanoscale computer circuitry and even the building blocks for an elevator extending into space. Their cost, however, is a bit of a problem: At $500 per gram, nanotubes are more than 30 times as expensive as gold. But that price may soon be on its way down.
Development of albumin monitoring system with hepatic hypoxia-on-a-chip (2023)

Hypoxia plays an essential role in the pathogenesis of various liver diseases, and albumin is one of the important biomarkers secreted by the liver. In this study, we developed an albumin monitoring system composed of hepatic hypoxia-on-a-chip and an albumin sensor to study liver function change due to hypoxia. In hepatic hypoxia-on-a-chip, we vertically stack an oxygen-scavenging channel on a liver on a chip with a thin gas-permeable membrane in the middle. This unique design of the hepatic hypoxia-on-a-chip can help to induce hypoxia quickly, attaining <5% within 10 min. An electrochemical albumin sensor was fabricated based on the covalent immobilization of antibodies on the Au electrode to monitor albumin secreting function on the hepatic hypoxia-on-a-chip. Standard albumin samples spiked in PBS, and culture media were measured by the electrochemical impedance spectroscopy using the fabricated immunosensor. The LOD was calculated to be 10 ag/mL in both cases. Using the electrochemical albumin sensor, we measured albumin secretion in normoxia and hypoxia in the chips. The albumin concentration decreased to 27% after 24 h in hypoxia compared to normoxia. This response was consistent with physiological studies. With technical refinements, the present albumin monitoring system can be a powerful tool in studying hepatic hypoxia with real-time liver function monitoring.
N,N′-Bis(3,5-di-t-butylsalicylidene)-1,2-cyclohexanediamino-manganese(III) chloride – the Jacobsen catalyst (1999)

The commercially available Jacobsen catalyst, N,N′-Bis(3,5-di-t-butylsalicylidene)-1,2-cyclohexanedi-aminomanganese(III) chloride 2, is the most enantioselective catalyst developed to date for the asymmetric epoxidation of a broad range of unfunctionalized olefins. After describing the synthesis of the title compound a brief discussion of the epoxidation mechanism is given. Afterwards several applications for the enantioselective epoxidation of unfunctionalized olefins are described. For each application the scope and limitations are discussed
Reviews of books (1975)

G. G. Cameron, J. H. Baxendale, K. R. Jenningh, A. K. Covington and G. Saville, J. Chem. Soc., Faraday Trans. 1, 1975, 71, 701 DOI: 10.1039/F19757100701
InP-based VCSELs with AlGaInAs/InP DBR and their applications (2008)

Designs and characteristics of InP-based VCSELs with AlGaInAs/InP DBR are reported. High temperature (≫85°C) and high speed (≫10Gbit/s) operation have been demonstrated. This VCSEL structure can be applicable to other applications such as tunable lasers.
Spatio-temporal features for tracking and quadruped/biped discrimination (2012)

Techniques such as SIFT and SURF facilitate efficient and robust image processing operations through the use of sparse and compact spatial feature descriptors and show much potential for defence and security applications. This paper considers the extension of such techniques to include information from the temporal domain, to improve utility in applications involving moving imagery within video data. In particular, the paper demonstrates how spatio-temporal descriptors can be used very effectively as the basis of a target tracking system and as target discriminators which can distinguish between bipeds and quadrupeds. Results using sequences of video imagery of walking humans and dogs are presented, and the relative merits of the approach are discussed.
Cytochrome P450 Genes of the CYP4 Clan and Pyrethroid Resistance in Chagas Disease Vectors (2022)

Triatomine insects are vectors of the protozoan Trypanosoma cruzi , the causative agent of Chagas disease. Although residual pyrethroid spraying has been a successful vector control strategy for many years, a growing number of pyrethroid-resistance foci is being documented, mainly in Triatoma infestans , that led to failures in vector elimination. Insecticide resistance is a multifactorial phenomenon that often implies a combination of three different mechanisms: increased insecticide detoxification, reduced affinity of the site of action, and reduced insecticide penetration through the cuticle. All three mechanisms were reported in pyrethroid-resistant T. infestans . Cytochrome P450s are enzymes involved in the metabolism of xenobiotics and endogenous chemicals. They are encoded by CYP genes and classified into different families and clans. In triatomines, the CYP4 clan is divided in two families, CYP3093 and CYP4, and both exhibit genome-wide, triatomine-specific gene expansions. Some members from each family have been reported to be involved in two of the mechanisms mentioned above, i.e., they participate in insecticide detoxification in different organs and tissues, and in the synthesis of cuticular hydrocarbons, which ultimately can contribute to a reduced insecticide penetration. The aim of this manuscript is to review the current state of knowledge of P450 genes belonging to the CYP4 clan in triatomines and to highlight their potential role in insecticide resistance.
MAPK-mediated phosphorylation of MKL2 regulates nuclear localization and transcriptional activity in striatal neurons (2018)

Dopamine (DA) type 1 receptor (D1R) signaling activates cAMP/Protein kinase A (PKA), which then activates Mitogen-Activated Protein Kinase (MAPK) through Rap1 finally activating transcription factors (TFs) in striatal medium spiny neurons (MSNs). These neurons play a pivotal role in reward-related behavior (Nagai T. et al. Neuron, 89, 1-16 (2016)). However, how D1R signaling regulates behavior through phosphorylation of these TFs is still largely unknown. It's known that CREB-binding protein (CBP) promotes transcription through the interaction with hundreds of different TFs and cofactors, and is also important for reward-related behavior. To isolate TFs regulated by DA signaling in MSNs, we performed a proteomic analysis for CBP-interacting proteins and identified more than 300 novel candidates in the mouse striatum. We focused on Myocardin Like 2 (MKL2) protein, which is a transcriptional co-activator of Serum Response Factor (SRF) highly expressed in the brain and known to regulate dendritic complexity. We found that interaction of CBP and MKL2 increased by cocaine administration. Furthermore, MKL2 formed a ternary complex with CBP and SRF in vivo. The C-terminal domain of MKL2, which can interact with KIX domain of CBP, was phosphorylated by MAPK at Serine 913. MAPK signaling induced MKL2 nuclear localization in striatal neurons and also increased SRF-response element promoter activity. These results demonstrate that MAPK downstream of DA signaling phosphorylates MKL2 and promotes MKL2 nuclear import facilitating interaction with CBP and regulating SRF-dependent gene expression.
Capsular Synovial Metaplasia as a Common Response to Both Textured and Smooth Implants (1996)

Recent reports suggested that the presence of synovial metaplasia in the capsular tissues of breast implants is greater with textured-shelled implants compared with smooth. Textured implants, however, have become popular only in the last few years. Therefore, the studies do not address the possibility that synovial metaplasia may be a dynamic process related to time (e.g., implant age) rather than implant shell surface. In the current study, 159 implant capsules (85 patients) removed between February of 1992 and July of 1993 at UCLA Medical Center were evaluated histologically and correlated with clinical data, including the age of implants. Synovial metaplasia was identified in 40 percent (64 of 159) of the capsule specimens. A logistic regression analysis that removed the effect of implant age demonstrated no correlation of implant shell type (textured versus smooth) with the presence of synovial metaplasia. Gel bleed, implant location, pericapsular fluid, implant rupture, and capsular contracture also did not have any significant association with synovial metaplasia in the current study. The incidence of synovial metaplasia appears to decrease with age (77 percent at < 5 years; 22 percent at > 15 years). Our findings suggest that synovial metaplasia is not rare and in fact may be a fairly common transitional histologic finding. It may be part of the common progression that occurs at the implant-capsule interface. The clinical significance remains unknown.
Bayesian Estimation of Common Areas in Multi-Camera Systems (2006)

In the paper a new Bayesian method is presented for the automatic extraction of common areas of images in multi-camera systems through the detection of concurrently changing pixels. Unlike existing still-image and motion-based methods our approach does not need any a priori information about the scene, the appearance of objects in the scene, or their motion. The method is validated by demonstrating its successful use on several real-life outdoor stereo video image-sequence pairs.
Fouling and Cleaning of Gas‐Filled Membranes for Cyanide Removal (2005)

Abstract Results of an experiment on the removal of cyanide from two industrial wastewaters by using gas‐filled hollow fiber membranes in a pilot plant in China are presented. The plant was operated in batch mode using 1000 L of feed solution. The plant contained 10 hollow fiber modules with a total effective membrane surface area of 180 m2. The strip stream consisted of a 10% NaOH solution. The overall mass transfer coefficient for cyanide was determined experimentally. A decrease in the overall mass transfer coefficient with time was observed for real wastewaters due to fouling of the membrane. In particular, the presence of particulate matter in the wastewater can lead to a significant decrease in the overall mass transfer coefficient and, hence, the rate of cyanide removal. Various cleaning strategies were investigated in order to regenerate the membrane. The gas‐filled membranes were stable for over two months of continuous operation when they were used with industrial wastewaters.
Familial Aggregation and Heritability of Electrocardiographic Intervals and Heart Rate in a Rural Chinese Population (2009)

Genetic factors, together with the environmental and other cofactors contribute no more than 60% to the variance of the ECG intervals, supporting the concept that multiple factors, including gene-gene and gene-environment interactions could influence ECG interval phenotypes, and genetic factors play a major role.