gebhart/patrepeval huggingface dataset:
Data from Novel Susceptibility Loci for Second Primary Tumors/Recurrence in Head and Neck Cancer Patients: Large-Scale Evaluation of Genetic Variants (2023)

&lt;div&gt;Abstract&lt;p&gt;This study was aimed to identify novel susceptibility variants for second primary tumor (SPT) or recurrence in curatively treated early-stage head and neck squamous cell carcinoma (HNSCC) patients.&lt;/p&gt;&lt;p&gt;We constructed a custom chip containing a comprehensive panel of 9,645 chromosomal and mitochondrial single nucleotide polymorphisms (SNP) representing 998 cancer-related genes selected by a systematic prioritization schema. Using this chip, we genotyped 150 early-stage HNSCC patients with and 300 matched patients without SPT/recurrence from a prospectively conducted randomized trial and assessed the association of these SNPs with risk of SPT/recurrence.&lt;/p&gt;&lt;p&gt;Individually, six chromosomal SNPs and seven mitochondrial SNPs were significantly associated with risk of SPT/recurrence after adjustment for multiple comparisons. A strong gene-dosage effect was observed when these SNPs were combined, as evidenced by a progressively increasing SPT/recurrence risk as the number of unfavorable genotypes increased (&lt;i&gt;P&lt;/i&gt; for trend &lt; 1.00 × 10&lt;sup&gt;−20&lt;/sup&gt;). Several polygenic analyses suggest an important role of interconnected functional network and gene-gene interaction in modulating SPT/recurrence. Furthermore, incorporation of these genetic markers into a multivariate model improved significantly the discriminatory ability over the models containing only clinical and epidemiologic variables.&lt;/p&gt;&lt;p&gt;This is the first large-scale systematic evaluation of germ-line genetic variants for their roles in HNSCC SPT/recurrence. The study identified several promising susceptibility loci and showed the cumulative effect of multiple risk loci in HNSCC SPT/recurrence. Furthermore, this study underscores the importance of incorporating germ-line genetic variation data with clinical and risk factor data in constructing prediction models for clinical outcomes.&lt;/p&gt;&lt;/div&gt;
Physiological effects of different interfaces during noninvasive ventilation for acute respiratory failure* (2009)

The internal volume of the masks had no apparent short-term dead space effect on gas exchange, minute ventilation, or patient's effort, suggesting that, with the exception of mouthpiece, interfaces may be interchangeable in clinical practice provided adjustment of the ventilatory device parameters are performed.
Développement de nanocomposites céramiques à base d'oxydes par sol-gel (2005)

Le sujet est la production des nanocomposites céramiques. Le système choisi est le matériau composite Al2O3/Y3Al5O12 (YAG). Pendant les premières années, le travail a été centré sur la mise à point de la technologie de synthèse de la poudre et sur la caractérisation des phases individuelles alumina et YAG. Pour le YAG a été effectuée une étude plus à fond sur l'effet de la température de synthèse sur son évolution cristalline et les paramètres cinétiques de nucleation et croissance des cristaux du YAG. En outre, il a été conduit une étude du comportement à frittage du composite qui a produit un composite très homogène mais avec taille des grains micronique. La troisième année a été centrée sur la mise à point des pré-traitements de la poudre (thermiques et mécaniques) pour améliorer le frittage et pour diminuer la température de densification. L'étude, en effet, a conduit à la production des nanocomposites avec taille de grain de 300 nm environ.
DNA methylation markers to assess biological age (2018)

Among the different biomarkers of aging based on omics and clinical data, DNA methylation clocks stand apart providing unmatched accuracy in assessing the biological age of both humans and animal models of aging. Here, we discuss robustness of DNA methylation clocks and bounds on their out-of-sample performance and review computational strategies for development of the clocks.
Temperature-Dependent Photoluminescence of Highly Strained InGaAsN/GaAs Quantum Wells (λ= 1.28–1.45 µm) with GaAsP Strain-Compensated Layers (2005)

The effects of nitrogen incorporation into the In 0.4 Ga 0.6 As 1- x N x /GaAs single quantum wells (SQWs), where x = 0.5 and 2%, grown on GaAs substrates by metalorganic chemical vapor deposition (MOCVD) were investigated using photoluminescence (PL) and high-resolution transmission electron microscopy (HRTEM). The evolution of the excitation-dependent PL and PL-peak position with temperature between 10 and 300 K shows that quantum-dot-like states occurred at that high nitrogen incorporation ( x = 2%) and were confirmed by an HRTEM image which showed small dark regions about 2–3 nm in size was found in the interface of In 0.4 Ga 0.6 As 0.98 N 0.02 and GaAs. Our investigations indicate that high nitrogen incorporation into the In 0.4 Ga 0.6 As 1- x N x /GaAs system influenced carrier localization and might cause the formation of the dot-like states.
Reaction of trimethylsilyl enol ethers with diols (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of trimethylsilyl enol ethers with diolsGerald L. Larson and Antonio HernandezCite this: J. Org. Chem. 1973, 38, 22, 3935–3936Publication Date (Print):November 1, 1973Publication History Published online1 May 2002Published inissue 1 November 1973https://doi.org/10.1021/jo00962a025RIGHTS & PERMISSIONSArticle Views375Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (296 KB) Get e-Alerts Get e-Alerts
Analysis of a Planar Solid Oxide Fuel Cell Based Automotive Auxiliary Power Unit (2002)

The solid oxide fuel cell (SOFC) system has emerged as an important technology for automotive and stationary applications. Modeling and simulation of the SOFC system have been utilized as an integral tool in an accelerated joint SOFC system development program. Development of unique modeling approaches and their results are discussed and compared with experimental performance. One dimensional system level analysis using Aspen with an embedded stack electro-chemical model was performed resulting in effective sub-system partitioning and requirements definition. Further, a three-dimensional integrated electro-chemical/thermal/computational fluid dynamics analysis of steady-state operation was employed. The combination of one-dimensional and three-dimensional environments led to effective performance projection at all levels in the system, resulting in optimization of overall system performance early in the design cycle.
A Comparison of Simulated and Experimental Voltammograms Obtained for the [Fe(CN)6]3-/4- Couple in the Absence of Added Supporting Electrolyte at a Rotating Disk Electrode (2001)

The voltammetric behavior of the [Fe(CN)6]3-/4- couple at a glassy carbon rotating macrodisk electrode without added supporting electrolyte is shown to be in close to ideal agreement with the theory presented over a wide range of electrode rotation and scan rates when the concentration of electroactive species used is 50 mM. The influences of migration, uncompensated resistance, heterogeneous charge-transfer kinetics, and inhomogeneous diffusion are shown to be well modeled by a finite difference simulation scheme that affords excellent agreement between experiment and theory. The use of the rotating disk electrode, even when only moderate rotation rates are employed, is shown to eliminate the problem with natural convection that exists when using stationary electrodes (macro- or microdisk) and that is enhanced in the absence of added supporting electrolyte. Consequently, it has been concluded that the rotating disk electrode method represents an almost ideal technique for conducting studies without added supporting electrolyte.
Comparable Survival in Patients With Unresectable Hepatocellular Carcinoma Treated by Radiofrequency Ablation or Transarterial Chemoembolization (2006)

The overall survival and time for disease progression were similar in both groups of patients. In terms of the survival result, the efficacies of RFA and TACE were comparable for patients with unresectable hepatocellular carcinoma.
229 GHz FSS for the MetOp second generation Microwave Sounder instrument (2016)

This paper describes the design of a frequency selective surface (FSS) which provides transmission of 228 - 230 GHz radiation and rejection from 164 - 191.3 GHz with insertion losses under 0.25 dB for TE wave polarization at 45° incidence. This state-of-the art filter topology consists of two air spaced freestanding perforated screens, comprising unit cell elements of resonant slots folded for the purpose of miniaturisation to enhance angular stability. The reported geometry enhances the angular stability (45° ± 10°) of the FSS beyond what is possible with canonical linear slots and satisfies the stringent electromagnetic performance requirements for signal demultiplexing in the quasi-optical feed train of the Microwave Sounder (MWS) instrument.
Surface conductivity of DR1-functionalized organic-inorganic sol-gel materials (2006)

In recent years, in looking for an important photorefractive application, several studies on electro-optic and photoconductive sol-gel responses have been done. A very important effort has been addressed to establish the appropriate induced-orientation procedure, in order to get the highest electro-optic coefficient. In this way a very high coefficient of 48 pm/V at 831 nm in sol-gel has been already found. Similarly, the importance of the non-linear chromophore concentration into the material electro-optic behavior has been studied. However, the influence of the orientation procedure and the chromophore concentration over the photoconductive response has not been performed. In this work we study the vacuum-surface-charge-transport under and without illumination after poling times of 10, 30 and 120 min on DR1-functionalized sol-gel thin films of 1.3 um in thickness with a suitable concentration of DR1. We include the measures before poling for other chromophore concentrations. We found the largest density of photocurrent at 633 nm for a poling time of 30 min. We also measured the order parameter in order to follow the Corona induced orientation evolution as function of time for each case. The saturation found into this parameter and into the photoconduction show the existence of an optimal poling time.
Religious Affiliation and Attendance Among Immigrants in Eight Western Countries: Individual and Contextual Effects (2006)

This study examines the religious affiliation and participation of immigrants from a large‐scale, comparative perspective. I propose a “specific migration” framework, in which immigrants' religiosity is an outcome of both individual characteristics and contextual properties related to immigrants' country of origin, country of destination, and combinations of origin and destination (i.e., communities). I use notions discussed in the religion and migration literature that fit into this scheme. To test these ideas, I collected and standardized 20 existing surveys on immigrants in eight Western countries, yielding about 38,000 immigrants. Applying multilevel models, I found, among other things, that: (1) immigrants from countries with higher levels of modernization express lower levels of religious commitment; (2) immigrants in religious countries are more religious themselves; and (3) the well‐documented higher levels of religious commitment among women is not generalizable to immigrants.
Adenosine for pain relief in a patient with intractable secondary erythromelalgia (1997)

An unusual case is reported with severe erythromelalgia secondary to a sensorimotor polyneuropathy of immunological aetiology. The dominating symptoms were ongoing burning dysesthesia and pain in the legs, sustained thermal hyperalgesia and allodynia to pressure which produced intolerable pain on standing and walking. The primary pain-producing pathophysiology was apparently peripheral neurogenic inflammation with sensitization and excitation of nociceptors. The variable and progressive course prompted reassessments and successively amended multitargeted analgesic regimens. The most intensive bout of widespread pain and allodynia indicating secondary central sensitization was only controlled by adenosine treatment.
Multislice perfusion imaging in human brain using the C-FOCI inversion pulse: Comparison with hyperbolic secant (1999)

Perfusion studies based on pulsed arterial spin labeling have primarily applied hyperbolic secant (HS) pulses for spin inversion. To optimize perfusion sensitivity, it is highly desirable to implement the HS pulse with the same slice width as the width of the imaging pulse. Unfortunately, this approach causes interactions between the slice profiles and manifests as residual signal from static tissue in the resultant perfusion image. This problem is currently overcome by increasing the selective HS width relative to the imaging slice width. However, this solution increases the time for the labeled blood to reach the imaging slice (transit time), causing loss of perfusion sensitivity as a result of T(1) relaxation effects. In this study, we demonstrate that the preceding problems can be largely overcome by use of the C-shaped frequency offset corrected inversion (FOCI) pulse [Ordidge et al., Magn Reson Med 1996;36:562]. The implementation of this pulse for multislice perfusion imaging on the cerebrum is presented, showing substantial improvement in slice definition in vivo compared with the HS pulse. The sharper FOCI profile is shown to reduce the physical gap (or "safety margin") between the inversion and imaging slabs, resulting in a significant increase in perfusion signal without residual contamination from static tissue. The mean +/- SE (n = 6) gray matter perfusion-weighted signal (DeltaM/M(o)) without the application of vascular signal suppression gradients were 1.19 +/- 0. 10% (HS-flow-sensitive alternating inversion recovery [FAIR]), and 1. 51 +/- 0.11% for the FOCI-FAIR sequence. The corresponding values with vascular signal suppression were 0.64 +/- 0.14%, and 0.91 +/- 0. 08% using the HS- and FOCI-FAIR sequences, respectively. Compared with the HS-based data, the FOCI-FAIR results correspond to an average increase in perfusion signal of up to between 26%-30%. Magn Reson Med 42:1098-1105, 1999.
ChemInform Abstract: DIE PROTONIERUNG VON METHYLCYCLOOCTATETRAEN‐EISENTRICARBONYL BEI NIEDEREN TEMPERATUREN (1972)

Abstract Das methylierte Cyclooctatetraen‐eisentricarbonyl (I) liefert mit Fluorsulfonsäure und Sulfurylfluorid bei ‐120°C isomere Protonierungsprodukte (II) und (III), die bei ‐62°C in die Bicyclo(5,l,O)octadieny1‐Komplexe (IV) und (V) übergehen.
Complete Genome Sequence of Lactobacillus rhamnosus Strain BPL5 (CECT 8800), a Probiotic for Treatment of Bacterial Vaginosis (2016)

ITALIC! Lactobacillus rhamnosusBPL5 (CECT 8800), is a probiotic strain suitable for the treatment of bacterial vaginosis. Here, we report its complete genome sequence deciphered by PacBio single-molecule real-time (SMRT) technology. Analysis of the sequence may provide insight into its functional activity.
Computing by molecular self-assembly (2012)

The paper reviews two computing models by DNA self-assembly whose proof of principal have recently been experimentally confirmed. The first model incorporates DNA nano-devices and triple crossover DNA molecules to algorithmically arrange non-DNA species. This is achieved by simulating a finite-state automaton with output where golden nanoparticles are assembled to read-out the result. In the second model, a complex DNA molecule representing a graph emerges as a solution of a computational problem. This supports the idea that in molecular self-assembly computing, it may be necessary to develop the notion of shape processing besides the classical approach through symbol processing.
Primary duodenal dedifferentiated liposarcoma: A case report and literature review (2022)

To the best of the authors' knowledge, this is the first case of primary duodenal DDLPS in Korea and the third case in the English-language literature. Care must be taken not to misdiagnose DDLPS as another high-grade tumor. Liposarcoma should be in the differential diagnosis list.
Rapid SARS-CoV-2 whole genome sequencing for informed public health decision making in the Netherlands (2020)

Abstract SARS-CoV-2 is a novel coronavirus that has rapidly spread across the globe. In the Netherlands, the first case of SARS-CoV-2 has been notified on the 27 th of February. Here, we describe the first three weeks of the SARS-CoV-2 outbreak in the Netherlands, which started with several different introductory events from Italy, Austria, Germany and France followed by local amplification in, and later also, outside the South of the Netherlands. The timely generation of whole genome sequences combined with epidemiological investigations facilitated early decision making in an attempt to control local transmission of SARS-CoV-2 in the Netherlands.
Novel and Specific Respiratory Syncytial Virus Inhibitors That Target Virus Fusion (1998)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTNovel and Specific Respiratory Syncytial Virus Inhibitors That Target Virus FusionWei-dong Ding, Boris Mitsner, Girija Krishnamurthy, Ann Aulabaugh, Cynthia D. Hess, Joe Zaccardi, Mark Cutler, Boris Feld, Anna Gazumyan, Yuri Raifeld, Antonia Nikitenko, Stanley A. Lang, Yakov Gluzman, Bryan O'Hara, and George A. EllestadView Author Information Departments of Bioorganic/Enzymology, Wyeth-Lederle Vaccines and Pediatrics, Medicinal Chemistry, and Infectious Diseases, Wyeth-Ayerst Research, Pearl River, New York 10965 Cite this: J. Med. Chem. 1998, 41, 15, 2671–2675Publication Date (Web):June 23, 1998Publication History Received20 April 1998Published online23 June 1998Published inissue 1 July 1998https://pubs.acs.org/doi/10.1021/jm980239ehttps://doi.org/10.1021/jm980239erapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views467Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Fluorescence,Infectious diseases,Inhibitors,Noncovalent interactions,Peptides and proteins Get e-Alerts
Aptámeros: agentes diagnósticos y terapéuticos = Aptamers: diagnostic and therapeutic agents (2012)

Los aptámeros son ácidos nucleicos de cadena sencilla, ADN o ARN, que reconocen una gran variedad de moléculas. Cada aptámero posee una estructura tridimensional particular que le permite unirse con afinidad y especificidad altas a la molécula diana. Los aptámeros tienen propiedades de reconocimiento equiparables a las de los anticuerpos; sin embargo, por la naturaleza de su composición tienen ventajas significativas en cuanto a su tamaño, producción y modificación. Estas características los hacen excelentes candidatos para el desarrollo de nuevas plataformas biotecnológicas. Se han identificado aptámeros con propiedades terapéuticas que han sido evaluados exitosamente en modelos animales; entre ellos, algunos se encuentran en fase clínica y uno ya fue aprobado para tratamiento por la FDA (Food and Drug Administration). Todos estos avances ocurridos durante las dos últimas décadas permiten anticipar el protagonismo que tendrán los aptámeros como agentes diagnósticos y terapéuticos en un futuro cercano.
20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat (2002)

This study examined the effects of blocking the formation of 20-hydroxyeicosatetraenoic acid (20-HETE) on the acute fall in cerebral blood flow after subarachnoid hemorrhage (SAH) in the rat. In vehicle-treated rats, regional cerebral blood flow (rCBF) measured with laser-Doppler flowmetry fell by 30% 10 min after the injection of 0.3 ml of arterial blood into the cisterna magna, and it remained at this level for 2 h. Pretreatment with inhibitors of the formation of 20-HETE, 17-octadecynoic acid (17-ODYA; 1.5 nmol intrathecally) and N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine (HET0016; 10 mg/kg iv), reduced the initial fall in rCBF by 40%, and rCBF fully recovered 1 h after induction of SAH. The concentration of 20-HETE in the cerebrospinal fluid rose from 12 +/- 2 to 199 +/- 17 ng/ml after SAH in vehicle-treated rats. 20-HETE levels averaged only 15 +/- 11 and 39 +/- 13 ng/ml in rats pretreated with 17-ODYA or HET0016, respectively. HET0016 selectively inhibited the formation of 20-HETE in rat renal microsomes with an IC(50) of <15 nM and human recombinant CYP4A11, CYP4F2, and CYP4F3 enzymes with an IC(50) of 42, 125, and 100 nM, respectively. These results indicate that 20-HETE contributes to the acute fall in rCBF after SAH in rats.
A Mechanism-Based Aryl Carrier Protein/Thiolation Domain Affinity Probe (2007)

The design, synthesis and biochemical characterization of a mechanism-based aryl carrier protein (ArCP) affinity probe that selectively modifies the terminal thiol of the aryl carrier protein phosphopantethein (Ppant) prosthetic group is described. Labeling of the aryl carrier protein was shown to require the cognate adenylating enzyme to channel the affinity probe onto the Ppant cofactor. The selective labeling was established by observation of the phosphopantetheinyl ejection ion via MS/MS and the probe was also found to stabilize an interaction between an aryl carrier protein and adenylating enzyme by an electrophoretic mobility shift assay.
Potentiation of Lonidamine and Diazepam, Two Agents Acting on Mitochondria, in Human Glioblastoma Treatment (1998)

The combination of lonidamine and diazepam--drugs that target two distinct mitochondrial sites involved in cellular energy metabolism--potentiates the effects of the individual drugs and may prove useful in the treatment of human glioblastomas.