gebhart/patrepeval huggingface dataset:
Coralyne binds tightly to both T.cntdot.A.cntdot.T- and C.cntdot.G.cntdot.C+-containing DNA triplexes (1993)

Coralyne is a DNA-binding antitumor antibiotic whose structure contains four fused aromatic rings. The interaction of coralyne with the DNA triplexes poly(dT).poly(dA).poly(dT) and poly[d(TC)].poly[d(GA)].poly[d(C+T)] was investigated by using three techniques. First, Tm values were measured by thermal denaturation analysis. Upon binding coralyne, both triplexes showed Tm values that were increased more than those of the corresponding duplexes. A related drug, berberinium, in which one of the aromatic rings is partially saturated, gave much smaller changes in Tm. Second, the fluorescence of coralyne is quenched in the presence of DNA, allowing the measurement of binding parameters by Scatchard analysis. The binding isotherms were biphasic, which was interpreted in terms of strong intercalative binding and much weaker stacking interactions. In the presence of 2 mM Mg2+, the binding constants to poly(dT).poly-(dA).poly(dT) and poly[d(TC)].poly[d(GA)].poly[(C+T)] were 3.5 x 10(6) M-1 and 1.5 x 10(6) M-1, respectively, while the affinity to the parent duplexes was at least 2 orders of magnitude lower. In the absence of 2 mM Mg2+, the binding constants to poly[d(TC)].poly[d(GA)].poly[d(C+T)] and poly-[d(TC)].poly[d(GA)] were 40 x 10(6) M-1 and 15 x 10(6) M-1, respectively. Thus coralyne shows considerable preference for the triplex structure but little sequence specificity, unlike ethidium, which will only bind to poly(dT).poly(dA).poly(dT). Further evidence for intercalation of coralyne was provided by an increase in the relative fluorescence quantum yield at 260 nm upon binding of coralyne to triplexes as well as an absence of quenching of fluorescence in the presence of Fe[(CN)6]4-.(ABSTRACT TRUNCATED AT 250 WORDS)
Two-band k · p model for Si-(110) electron devices (2013)

Carrier transport in Si-(110) surfaces is a topic of growing interest because of its presence in the lateral interfaces of vertical structures, such as FinFETs or tri-gate devices. It has been shown that the parabolic effective mass model cannot explain the experimental behavior of electron mobility in Si-(110) surfaces, and the strongly non-parabolic conduction band structure obtained by more accurate (and complex) methods is needed. A simpler model that can reproduce the required non-parabolic features of conduction band structure is described by a two-band k · p Hamiltonian. In this paper, we show the analytic solution of such a model for a square-well potential and a numerical implementation in a coupled Poisson-Schrödinger solver and one-particle Monte Carlo simulator. The electron mobility calculations are in good agreement with experimental results for bulk MOSFETs and SOI devices.
Self-catalyzed growth of GaAs nanowires on silicon for tandem solar cells (2015)

poster MoP.16
Effects of biliary obstruction on pulmonary ultrastructure in the rat. (1972)

Hypoxemia and respiratory alkalosis have been described in patients with liver disease. Since no pulmonary parenchymal lesions have been related to the abnormal respiratory function, the effects of common bile duct ligation and division on pulmonary alveolar structure were studied in ninety-two 10- to 14-week-old male Wistar rats. In comparison with controls, the rats with ligated common bile ducts (CBD) developed progressive hepatic and pulmonary changes. The hepatic damage consisted of bile duct proliferation, loss of hepatocytes and generalized cirrhosis. Most pronounced pulmonary histologic differences between the CBD and sham-operated rats were thickening of interalveolar septa and generalized increase in cellularity of alveolar walls. With electron microscopy, frequently observed alterations included swelling and increased vacuolization of endothelial and epithelial (Type I) cells, proliferation of Type II alveolar pneumonocytes, and increase in amounts of collagen fibers and edema of the interstitium.
Modeling and simulation of the electrothermal behavior of the power bipolar transistor (2002)

We have developed a one-dimensional electrothermal model for the bipolar power transistor, implemented in the SABER circuits simulator, in which the device's temperature becomes an interactive variable during the simulation. The accuracy of the model is appreciated with the electrical and thermal characterization of a NPvN power bipolar transistor using the IC-CAP-SABER interface. The internal behavior of the transistor during transients is shown up through a switching simulation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Method for a Posteriori Identification of Knee Points Based on Solution Density (2018)

Many evolutionary algorithms have been proposed and demonstrated to have excellent performance in striking a balance between convergence and diversity in dealing with multiobjective optimization problems. However, little attention has been paid to the decision making stage where a small number of solutions are selected to be presented to the user. It is believed that knee points are considered to be the naturally preferred solutions when no specific preferences are available, because knee solutions incur a large loss in at least one objective to gain a small amount in other objectives. One common issue in the identification of knee points is that some knee points are easily ignored and knees in concave regions are hard to be identified. To resolve these issues, this paper proposes a novel method for knee identification, which first maps the non-dominated solutions to a constructed hyperplane and then divides them into groups, each representing a candidate knee region, based on the density of the solutions projected on the hyperplane. Finally, the convexity and curvature of the candidate knee groups are determined and only those having a strong curvature are kept. The proposed method is empirically demonstrated to be effective in identifying knee points located in both convex and concave regions on three existing test problems and one newly proposed test problem.
ChemInform Abstract: AMIN‐KOMPLEXVERBINDUNGEN (C2H5)3N.HGE(R)CL2 UND AUF IHRER GRUNDLAGE BERUHENDE HERSTELLUNG VON DIORGANO‐DICHLORGERMAN (1975)

Abstract Äthyl‐trichlorgerman (I) wird durch Trichlorsilan (II) und Triäthylamin (III) in Heptan bei 98°C zu Äthyl‐dichlorgerman reduziert, das mit Triäthylamin als Komplexverbindung (IV) abgeschieden wird.
Guided Internet-Based Parent Training for Challenging Behavior in Children With Fetal Alcohol Spectrum Disorder (Strongest Families FASD): Study Protocol for a Randomized Controlled Trial (2015)

ClinicalTrials.gov NCT02210455; https://clinicaltrials.gov/ct2/show/NCT02210455 (Archived by WebCite at http://www.webcitation.org/6bbW5BSsT).
Preface to Forum on “Current Trends in Functional Surfaces and Interfaces for Biomedical Applications” (2016)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTPreface to Forum on "Current Trends in Functional Surfaces and Interfaces for Biomedical Applications"Kirk S. Schanze and Jonathan J. MallettCite this: ACS Appl. Mater. Interfaces 2016, 8, 24, 14895Publication Date (Web):June 22, 2016Publication History Published online22 June 2016Published inissue 22 June 2016https://pubs.acs.org/doi/10.1021/acsami.6b06711https://doi.org/10.1021/acsami.6b06711editorialACS PublicationsCopyright © 2016 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views566Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (116 KB) Get e-AlertscloseSUBJECTS:Anatomy,Biomaterials,Cells,Interfaces,Thin films Get e-Alerts
Psychology of Touch and Blindness (2013)

This book reviews the considerable body of research that has been done to evaluate the touch skills of blind people. With an emphasis on cognitive and neuroscientific approaches, it encompasses a wide-ranging discussion of the theoretical issues in the field of touch perception and blindness. The volume includes chapters on sensory aspects of touch, perception in blind individuals, multimodal relations and their implications for instruction and development, and new technology, including sensory aids and virtual touch. A distinctive feature of the book is the inclusion of the practical applications of research in this area. A significant characteristic of research on touch and imagery in congenitally blind individuals is that it speaks to the basic nature of spatial imagery and the importance and necessity -- or lack thereof -- of specific visual sensory experience for the acquisition of knowledge about space, spatial layout, and picture perception. As such, the book will not only appeal to researchers and professionals with an interest in touch and blindness, but also to a wider audience of cognitive psychologists and cognitive neuroscientists working in the field of perception.
Performance Analysis of Carrier-Aggregated Multiantenna 4 × 4 MIMO LTE-A Fronthaul by Spatial Multiplexing on Multicore Fiber (2017)

In this paper, we experimentally propose and evaluate the performance of multiantenna LTE-Advanced (LTE-A) systems implementing multiple-input-multiple-output (MIMO) space division multiplexing on multicore fiber, compared to single-antenna single-antenna system (SISO) transmissions. Fully standard 3GPP LTE-A cellular signals are transmitted with MIMO and carrier aggregation in radio-over-fiber over a four-core fiber in different configurations. The processing capabilities of in-built 3GPP MIMO processing are evaluated experimentally in two-antenna and four-antenna LTE-A configurations and compared with single-antenna SISO performance. The robustness of 3GPP MIMO processing is analyzed over different optical paths in a four-core fiber and the optical power margin available between the four optical paths is calculated for each configuration. Finally, the transmission performance of carrier-aggregated LTE-A signals is evaluated in the four-antenna system implementing 4 × 4 MIMO spatial multiplexing with different carrier separation and center frequency configurations, including regulated cellular frequencies of frequency division duplex bands 7 and 20.
Ultralarge capacitance–voltage hysteresis and charge retention characteristics in metal oxide semiconductor structure containing nanocrystals deposited by ion-beam-assisted electron beam deposition (2001)

Amorphous silicon films are deposited by ion-beam-assisted electron beam deposition and subsequently oxidized by a rapid thermal oxidation process. The oxidized film contains a large density of nanocrystals specifically localized at a certain depth from the Si/SiOx interface, whereas no evidence of nanocrystals is found for oxidized films deposited without ion beam assistance. Such a marked contrast resulted from the enhancement of nucleation rate by ion beam irradiation. The metal-oxide-semiconductor structure utilizing the film shows an ultralarge capacitance–voltage hysteresis whose width is over 20 V. In addition capacitance–time measurement shows a characteristic capacitance transient indicating nondispersive carrier relaxation. The retention time shows a dependence on applied bias and the maximum time of ∼70 s is obtained near midgap voltage. The retention time dependence on applied bias and large capacitance–voltage hysteresis are attributed to direct tunneling of trapped charges in the deep traps of nanocrystals to the interface states.
Reversible Morphology Locking via Metal Infiltration in a Block Copolymer (2023)

Metal infiltration from an acid solution of a metal precursor into the poly(2-vinylpyridine) (P2VP) microdomains of a polystyrene-<i>b</i>-P2VP block copolymer is shown to reduce the uptake of solvent vapor during a subsequent solvent annealing process, locking the morphology of the self-assembled microdomains. The amount of metal, here Pt, incorporated into the P2VP increases with both metal precursor [PtCl<sub>4</sub>]<sup>2-</sup> and hydrochloric acid concentrations, reaching 0.83 Pt atom per pyridine unit. The metal is then exfiltrated using a KOH + ethylenediaminetetraacetic acid disodium salt dihydrate (Na<sub>2</sub>EDTA) complexing solution, which restores solvent uptake and unlocks the morphology. The reversibility of the metal infiltration and morphology locking is demonstrated in a multistage annealing process and is confirmed for Fe as well as Pt. Reversible locking and unlocking of block copolymer microdomain morphologies expand their utility for nanofabrication processes by allowing the morphology to be fixed during subsequent process steps.
Extrageniculostriate vision in the monkey. VII. Contrast sensitivity functions (1980)

1. Psychophysical and electrophysiological experiments have indicated the importance of spatial frequency components and their respective contrasts and orientations for the recognition of patterns. It is in the striate cortex where these types of information first converge, a fact that lends support to the accepted crucial role of this structure in pattern discrimination. 2. Monkeys with total bilateral ablation of the striate cortex, however, retain a residual capacity for pattern discrimination and also can differentiate between a vertical and an oblique luminous bar. The present study explores their capacity for spatial frequency detection both as a function of contrast and, by extrapolation, at maximum contrast (visual acuity measure). 3. Monkeys were presented with a forced choice between a homogeneous target and a vertically oriented sinusoidal grating in a pulling-in apparatus. Stimuli were produced by the transillumination of transparencies at spatial frequencies of 0.5, 1.0, 2.0, 4.0, 8.0, 16, and 32 cycles/deg, in 0.1-log unit steps of contrast from 0.79 to 0.006. The stimuli subtended 8 degrees of visual angle and were matched for mean luminance at 20 cd/m2. After mastering the discrimination of one spatial frequency at the highest contrast, contrast thresholds were first estimated by a staircase technique, and then determined by the method of constant stimuli. The procedure was repeated for each spatial frequency before and after histologically verified total bilateral removal of striate cortex and partial damage to circumstriate cortices. 4. Discrimination at all spatial frequencies was mastered by all normal monkeys. Postoperatively, they could solve only problems with frequencies between 0.5 and 4.0 cycles/deg. 5. Contrast sensitivity (threshold-1) functions for normal and destriated monkeys have the characteristic inverted J shape. The high- and low-frequency limbs are related exponentially to spatial frequency, and the peak of the curve is about 2.0 cycles/deg. The dimensions of the functions, however, change significantly following the ablation. Sensitivity is depressed at all spatial frequencies. The mean "visuogram" indicates a 26-dB flat loss. 6. The mean high-frequency cutoff point is 43 cycle/deg preoperatively and 12 cycles/deg postoperatively, equivalent to 0.7' and 2.5' of arc, respectively. The latter value is not worse than 20/80 on the Snellen chart. 7. The variability of the response at each spatial frequency in the staircase method and the slope of the psychometric function derived from the method of constant stimuli provide a measure of "instability" and "precision," respectively, which are inversely related. Preoperatively, precision is significantly greater at high than at low spatial frequencies. Postoperatively, it is similar at all frequencies, and the values are lower than those determined preoperatively. 8. The results demonstrate that destriated monkeys can detect gratings, although to a lesser degree than normal animals...
Inhibition of nitrification by ammonia and nitrous acid (1976)

THE IMPORTANCE OF NITRIFICATION has been recognized for more than a cen tury. Engineers and scientists continue to investigate the process to obtain a better understanding of the fundamentals and to use the process for the benefit of man. Controlled nitrification may occur during waste treatment, and engineers have begun to incorporate the process as part of nitri fication-denitrification systems for nitrogen control preceding discharge of the treated wastes.
Infection with human rhinovirus 16 promotes enhanced IgE responsiveness in basophils of atopic asthmatics (2014)

Circulating basophils display increased IgE responsiveness 3 weeks after rhinovirus infection in atopic asthmatics. This observation, coupled with increased expression of Syk, implicates basophils in promoting, or else prolonging, rhinovirus-induced inflammation in atopic asthmatics.
ChemInform Abstract: Synthesis and Properties of the Piperidine Salts of 6‐Hydroxy‐4,6‐diaryl‐5‐ethoxycarbonyl‐3‐cyanopiperidine‐2‐thione. (1987)

Abstract The benzoylacetic acid ester (I) is cyclized with the benzaldehydes (II) and cyanothioacetamide (III) in the presence of piperidine (IV) to give the 3‐cyanopiperidine‐2‐thione salts (V).
Product Analysis and Inhibition Studies of a Causative Asn to Ser Variant of 4-Hydroxyphenylpyruvate Dioxygenase Suggest a Simple Route to the Treatment of Hawkinsinuria (2010)

Hawkinsinuria is a severe inherited condition that has a significant impact on the health of infants. The disease manifests as metabolic acidosis that significantly slows the growth rate and induces persistent diarrhea and vomiting. Though other causes may exist, an autosomal dominant mutation that alters codon 241 of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) gene from encoding an asparagine to encoding a serine gives rise to the symptoms of the disease. The observed pattern of dominance of this mutation belies the paucity of reports of this disease in the literature and suggests that it may be rarely diagnosed. Diagnosis is based on the presence of 2-amino-3-{[2-(carboxymethyl)-2,5-dihydroxy-1-cyclohex-3-enyl]sulfanyl}propanoic acid (hawkinsin) in the urine. We have made the structurally equivalent mutation in the Streptomyces avermitilis (N245S) and rat (N241S) genes and shown that in both cases the N to S variant enzyme forms quinolacetic acid in place of the native product 2,5-dihydroxyphenylacetic acid (homogentisate). Importantly, the variant enzyme is highly active, establishing the basis for dominant pedigree pattern. Quinolacetic acid reacts readily by Michael addition with cellular thiols to form a two-electron oxidized form of hawkinsin. The N to S variants are also susceptible to inhibition by 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione (NTBC), a known inhibitor of wild-type HPPD. NTBC has been approved for use in the treatment of type I tyrosinemia and as such has an extensive history of use with infants. The N to S variant undergoes an apparent three-step binding mechanism with NTBC that forms with rate constants similar to those observed for the wild-type enzyme. Moreover, the extreme stability of the HPPD.NTBC complex suggests that NTBC would be a potent therapeutic for Hawkinisinuria that would alleviate the extreme frailty experienced in the early life period.
Electronic structure of bulk manganese oxide and nickel oxide from coupled cluster theory (2020)

We describe the ground- and excited-state electronic structure of bulk MnO and NiO, two prototypical correlated electron materials, using coupled cluster theory with single and double excitations (CCSD). As a corollary, this work also reports an implementation of unrestricted periodic ab initio equation-of-motion CCSD. Starting from a Hartree-Fock reference, we find fundamental gaps of 3.46 and 4.83 eV for MnO and NiO, respectively, for the 16-unit supercell, slightly overestimated compared to experiment, although finite-size scaling suggests that the gap is more severely overestimated in the thermodynamic limit. From the character of the correlated electronic bands we find both MnO and NiO to lie in the intermediate Mott/charge-transfer insulator regime, although NiO appears as a charge transfer insulator when only the fundamental gap is considered. While the lowest quasiparticle excitations are of metal $3d$ and O $2p$ character in most of the Brillouin zone, near the $\mathrm{\ensuremath{\Gamma}}$ point, the lowest conduction band quasiparticles are of $s$ character. Our study supports the potential of coupled cluster theory to provide high-level many-body insights into correlated solids.
MedEvi: Retrieving textual evidence of relations between biomedical concepts from Medline (2008)

http://www.ebi.ac.uk/tc-test/textmining/medevi/
Participation of Smad2, Smad3, and Smad4 in Transforming Growth Factor β (TGF-β)-induced Activation of Smad7 (2000)

Smad7 has recently been identified as a player that antagonizes transforming growth factor beta (TGF-beta) signals by acting downstream of TGF-beta receptors. TGF-beta rapidly induces expression of Smad7 mRNA in a variety of cell types, suggesting participation in a negative feedback loop to control TGF-beta responses. We have previously described the genomic locus of rat Smad7 including the promoter region. Here we report polymerase chain reaction cloning of the corresponding promoter regions of human and murine Smad7 genes and functional characterization of the rat Smad7 promoter. Using transient transfection experiments of HepG2 cells, we identified the TGF-beta response element within a strongly conserved region, containing a perfect Smad binding element (SBE; GTCTAGAC). Performing electrophoretic mobility shift assay and cotransfection experiments, we were able to delineate DNA-binding complexes and identified Smad3, Smad4, and Smad2. Mutation of the SBE completely abolished TGF-beta inducibility of Smad7 in HepG2 cells, indicating that this sequence is necessary for TGF-beta-induced transcription. Furthermore, a 3-base pair adjacent E-box is additionally essential for TGF-beta-dependent promoter activation and an overlapping AP1 site is also involved. We conclude that regulation of Smad7 transcription by TGF-beta is mediated via a specific constellation of recognition motifs localized around the SBE, which is conserved in human, rat, and murine genes.
Estudio conceptual sobre los Centros de Justicia Restaurativa (2015)

Ser joven y vivir en comunidades economicamente deprimidas aumenta considerablemente el riesgo de ser victima de delitos violentos: una encuesta nacional realizada a menores de entre 10 y 16 anos demostro que mas de la mitad habian sido victimas de violencia. A su vez, un estudio realizado por el Consejo Nacional sobre el Crimen y la Delincuencia hallo que el factor mas importante para predecir la conducta criminal por parte de los adolescentes era haber sido victimas de algun delito.
Los Centros de Justicia Restaurativa son lugares de la comunidad (organizaciones comunitarias o confesionales) que ofrecen prevencion eficaz de la violencia y estrategias de intervencion a jovenes judicializados y pandilleros y a sus familias, proporcionando un entorno estructurado y de apoyo que promueva la sanacion y el desarrollo pro social.
El articulo revisa la creacion y desarrollo de los Centros de Justicia Restaurativa organizados en Chicago para la atencion de esta problematica, su mision, vision y valores, asi como los programas que se desarrollan.