gebhart/patrepeval huggingface dataset:
Perioral granulomatous dermatitis: two cases treated with clarithromycin (2000)

BACKGROUND: Two young patients with numerous flesh-coloured micropapular lesions involving the perioral and perinasal areas presented to us. In both cases the facial eruption had appeared during application of topical corticosteroids for a mild seborrhoeic dermatitis of the face. Histopathological examination revealed a sarcoid-like granulomatous reaction leading to a granulomatous perioral dermatitis. METHODS: We treated the first patient initially with minocycline 100 mg/day, but after 1 month and no improvement treatment with oral clarithromycin 250 mg/day was commenced for 6 weeks and then 125 mg/day for a further 2 months. The second patient began treatment with doxycycline 100 mg/day for 50 days and was then transferred to clarithromycin 250 mg/day for 10 days and then 250 mg on alternate days for 20 further days. RESULTS: In both patients, treatment with oral clarithromycin led to complete clearance of the facial eruptions. CONCLUSION: Clarithromycin is considered to be a useful alternative to tetracycline in the treatment of perioral granulomatous dermatitis. (J Dermatol Treat (2000) 11:57–61)
Phages recognizing the Indium Nitride semiconductor surface via their peptides (2010)

Considerable advances in materials science are expected via the use of selected or designed peptides to recognize material, control their growth, or to assemble them into elaborate novel devices. Identifying specific peptides for a number of technologically useful materials has been the challenge of many research groups in recent years. This can be accomplished by using affinity-based bio-panning methods such as phage display technologies. In this work, a combinatorial library including billions of clones of genetically engineered M13 bacteriophage was used to select peptides that could recognize improved indium nitride (InN) semiconductor (SC) material. Several rounds of biopanning were necessary to select the phage with the higher affinity from the low variant library. The DNA of this specific phage was extracted and sequenced to set up the related specific adherent peptide. Atomic force microscopy (AFM) is used to demonstrate the real affinity of a selected phage for the InN surface. Due to the possibility of its functionalization with biomolecules and its important physical properties, InN is a promising candidate for developing affinity-based optical and electrical biosensors and/or for biomimetic applications.
ONG: UN JUEGO DE OPUESTOS (*) (2008)

El fenómeno de las ONG no es considerado de modo equivalente por quienes lo analizan. Concretamente, existen visiones no sólodiferentes, sino opuestas. En este trabajo nos proponemos presentar dos, para mostrarlas como dables de articularse.Rescataremos lo que ambas poseen como posible "puente": veremos a la asociación y el ejercicio concreto de la solidaridad vis avis cuestiones acerca del oenegeísmo, que distorsionan aún más al objetado Primer Sector -obligando al particular a hacer lo quea ése le compete. Intentaremos arribar, así, a una conjugación que no desafíe ni invalide ninguna de las dos posturas; sino que,luego de dinamizarlas, no olvide que cada una presenta su núcleo sólido de validez en sí misma.
Demo (2017)

Despite years of innovative research and development, multi-Gbps 60 GHz wireless networks are still not mainstream. The unfavorable propagation characteristics due to short wavelength and high directionality, makes the 60 GHz links highly vulnerable to blockage and mobility. However, the advent of multi-band chipsets opens the possibility of leveraging the more robust WiFi technology to assist 60 GHz in order to provide seamless, Gbps connectivity. In this demonstration, we will present MUST, an 802.11-compliant real-time system that provides seamless, high-speed connectivity over multi-band 60 GHz and WiFi devices. MUST has two key design components: (1) a WiFi-assisted 60 GHz link adaptation algorithm, which can instantaneously predict the best beam and PHY rate setting, with zero probing overhead at 60 GHz; and (2) a proactive blockage detection and switching algorithm which can re-direct ongoing user traffic to the robust interface within sub-10 ms latency. We have implemented MUST on off-the-shelf devices where our experiments show high throughput gain and almost 2 orders of magnitude cross-band switching latency improvement over state-of-the-art solutions.
C‐Glycoside Analogues of N4‐(2‐Acetamido‐2‐deoxy‐β‐D‐glucopyranosyl)‐L‐asparagine: Synthesis and conformational analysis of a cyclic C‐glycopeptide (1996)

Abstract The synthesis of C ‐glycosidic analogues 15–22 of N 4 ‐(2‐acetamido‐2‐deoxy‐β‐ D ‐glucopyranosyl)‐ L ‐asparagine (Asn( N 4 GlcNAc)) possessing a reversed amide bond as an isosteric replacement of the N ‐glycosidic linkage is presented. The peptide cyclo(‐ D ‐Pro‐Phe‐Ala‐CGaa‐Phe‐Phe‐) (CGaa = C ‐glycosylated amino acid; 24 ) was prepared to demonstrate that 3‐[(3‐acetamido‐2,6‐anhydro‐4,5,7‐tri‐ O ‐benzyl‐3‐deoxy‐β‐ D ‐glycero‐ D ‐guloheptonoyl)amino]‐2‐[(9 H ‐fluoren‐9‐yloxycarbonyl)amino]propanoic acid ( 22 ) can be used in solid‐phase peptide synthesis. The conformation of 24 was determined by NMR and molecular‐dynamics (MD) techniques. Evidence is provided that the CGaa side chain interacts with the peptide backbone. The different C ‐glycosylated amino acids 15–21 were prepared by coupling 3‐acetamido‐2,6‐anhydro‐4,5,7‐tri‐ O ‐benzyl‐3‐deoxy‐β‐ D ‐ glycero ‐ D ‐ gulo ‐heptonic acid ( 4 ) with diamino‐acid derivatives 8–14 in 83–96% yield. The synthesis of 4 was performed from 2‐(acetamido‐3,4,6‐tri‐ O ‐benzyl‐2‐deoxy‐β‐ D ‐glucopyranosyl) tributylstannane ( 2 ) by treatment with BuLi and CO 2 in 83% yield. Similarly, propyl isocyanat yielded the glycoheptonamide 7 in 52% from 2 . Compound 2 was obtained from 2‐acetamido‐3,4,6‐tri‐ O ‐benzyl‐2‐deoxy‐ D ‐glucopyranose ( 1 ) by chlorination and addition of tributyltinlithium in 74% yield. A procedure for a multigram‐scale synthesis of 1 is given.
Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues (2020)

Rare perivascular mesenchymal stromal cells (MSCs) with therapeutic properties have been identified in many tissues. Their rarity necessitates extensive in vitro expansion, resulting in spontaneous differentiation, cellular senescence and apoptosis, producing therapeutic products with variable quality and decreased potency. We previously demonstrated that A83-01, a transforming growth factor beta (TGF-β) receptor inhibitor, maintained clonogenicity and promoted the potency of culture-expanded premenopausal endometrial MSCs using functional assays and whole-transcriptome sequencing. Here, we compared the effects of A83-01 on MSCs derived from postmenopausal endometrium, menstrual blood, placenta decidua-basalis, bone marrow and adipose tissue. Sushi-domain-containing-2 (SUSD2<sup>+</sup>) and CD34<sup>+</sup>CD31<sup>-</sup>CD45<sup>-</sup> MSCs were isolated. Expanded MSCs were cultured with or without A83-01 for 7 days and assessed for MSC properties. SUSD2 identified perivascular cells in the placental decidua-basalis, and their maternal origin was validated. A83-01 promoted MSC proliferation from all sources except bone marrow and only increased SUSD2 expression and prevented apoptosis in MSCs from endometrial-derived tissues. A83-01 only improved the cloning efficiency of postmenopausal endometrial MSCs (eMSCs), and expanded adipose tissue MSCs (adMSCs) underwent significant senescence, which was mitigated by A83-01. MSCs derived from bone marrow (bmMSCs) were highly apoptotic, but A83-01 was without effect. A83-01 maintained the function and phenotype in MSCs cultured from endometrial, but not other, tissues. Our results also demonstrated that cellular SUSD2 expression directly correlates with the functional phenotype.
A novel dehumidification technique using electric field (1996)

A completely new concept of dehumidification is presented. The polar nature of the electronic bond structure between oxygen and hydrogen atoms in a water molecule is utilized to attract them using an electric field. It is possible to single out and remove the water molecules from the air inside a room to make the room dehumidified. A theoretical formulation is developed and a simple experiment was performed to validate the theory. Unlike the conventional dehumidification process, this process does not involve any condensation of the moisture and hence requires a very small amount of power. The technique can also be very useful for air-conditioning as well.
Potential Role of Protein Kinase B in Glucose Transporter 4 Translocation in Adipocytes* (1997)

Phosphatidylinositol 3-kinase (PI 3-kinase) activation promotes glucose transporter 4 (Glut 4) translocation in adipocytes. In this study, we demonstrate that protein kinase B, a serine/threonine kinase stimulated by PI 3-kinase, is activated by both insulin and okadaic acid in isolated adipocytes, in parallel with their effects on Glut 4 translocation. In 3T3-L1 adipocytes, platelet-derived growth factor activated PI 3-kinase as efficiently as insulin but was only half as potent as insulin in promoting protein kinase B (PKB) activation. To look for a potential role of PKB in Glut 4 translocation, adipocytes were transfected with a constitutively active PKB (Gag-PKB) together with an epitope tagged transporter (Glut 4 myc). Gag-PKB was associated with all membrane fractions, whereas the endogenous PKB was mostly cytosolic. Expression of Gag-PKB led to an increase in Glut 4 myc amount at the cell surface. Our results suggest that PKB could play a role in promoting Glut 4 appearance at the cell surface following exposure of adipocytes to insulin and okadaic acid stimulation.
Association between skirt size and chronic liver disease in post-menopausal women: a prospective cohort study within the United Kingdom Trial of Ovarian Cancer Screening (UKCTOCS) (2018)

UKCTOCS is registered as an International Standard Randomised Controlled Trial, number ISRCTN22488978 . Registered 06/04/2000.
Extracorporeal Membrane Oxygenation (2013)

Pediatric Critical Care Division, Children’s Healthcare of Atlanta at Egleston, Emory University School of Medicine, Atlanta, GA Dr. Fortenberry disclosed a patent for improved fluid accuracy in pediatric continuous renal replacement therapy (device in development but not currently in production).
SoK: Network-Level Attacks on the Bitcoin P2P Network (2022)

Over the last decade, Bitcoin has revolutionized the global economic and technological landscape, inspiring a new generation of blockchain-based technologies. Its protocol is today among the most influential for cryptocurrencies and distributed networks. In particular, the P2P layer represents a reference point for all permissionless blockchains, which often implement its solutions in their network layer. Unfortunately, the Bitcoin network protocol lacks a strong security model, leaving it exposed to several threats. Attacks at this level can affect the reliability and trustworthiness of the consensus layer, mining the credibility of the whole system. It is therefore of utmost importance to properly understand and address the security of the Bitcoin P2P protocol. In this paper, we give a comprehensive and detailed overview of known network-level attacks in Bitcoin, as well as the countermeasures that have been implemented in the protocol. We propose a generic network adversary model, and propose an objective-based taxonomy of the attacks. Finally, we identify the core weaknesses of the protocol and study the relationship between different types of attack. We believe our contribution can help both new and experienced researchers have a broader and deeper understanding of the Bitcoin P2P network and its threats, and allow for a better modeling of its security properties.
The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients (2018)

Abstract Purpose: Previous studies using FLASH radiotherapy (RT) in mice showed a marked increase of the differential effect between normal tissue and tumors. To stimulate clinical transfer, we evaluated whether this effect could also occur in higher mammals. Experimental Design: Pig skin was used to investigate a potential difference in toxicity between irradiation delivered at an ultrahigh dose rate called “FLASH-RT” and irradiation delivered at a conventional dose rate called “Conv-RT.” A clinical, phase I, single-dose escalation trial (25–41 Gy) was performed in 6 cat patients with locally advanced T2/T3N0M0 squamous cell carcinoma of the nasal planum to determine the maximal tolerated dose and progression-free survival (PFS) of single-dose FLASH-RT. Results: Using, respectively, depilation and fibronecrosis as acute and late endpoints, a protective effect of FLASH-RT was observed (≥20% dose-equivalent difference vs. Conv-RT). Three cats experienced no acute toxicity, whereas 3 exhibited moderate/mild transient mucositis, and all cats had depilation. With a median follow-up of 13.5 months, the PFS at 16 months was 84%. Conclusions: Our results confirmed the potential advantage of FLASH-RT and provide a strong rationale for further evaluating FLASH-RT in human patients. See related commentary by Harrington, p. 3
Distinct Cellular Patterns of Upregulated Chemokine Expression Supporting a Prominent Inflammatory Role in Traumatic Brain Injury (2008)

Cerebral gene expressions change in response to traumatic brain injury (TBI), and future trauma treatment may improve with increased knowledge about these regulations. We subjected C57BL/6J mice to injury by controlled cortical impact (CCI). At various time points post-injury, mRNA from neocortex and hippocampus was isolated, and transcriptional alterations studied using quantitative real-time polymerase chain reaction (PCR) and gene array analysis. Spatial distribution of enhanced expression was characterized by in situ hybridization. Products of the upregulated transcripts serve functions in a range of cellular mechanisms, including stress, inflammation and immune responses, and tissue remodeling. We also identified increased transcript levels characterizing reactive astrocytes, oligodendrocytes, and microglia, and furthermore, we demonstrated a novel pattern of scattered cell clusters expressing the chemokine Cxcl10. Notably, a sustained increase in integrin alpha X (Itgax), characterizing antigen-presenting dendritic cells, was found with the transcript located to similar cell clusters. In contrast, T-cell receptor alpha transcript showed only a modest increase. The induced P-selectin (Selp) expression level in endothelial cells, and chemokines from microglia, may guide perivascular accumulation of extravasating inflammatory monocytes differentiating into dendritic cells. In conclusion, our study shows that following TBI, secondary injury chiefly involves inflammatory processes and chemokine signaling, which comprise putative targets for pharmaceutical neuroprotection.
High Atom Efficiency in Sc(OTf)3‐Catalyzed Allylation of Aldehydes with Tetraallyltin. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
"Cut me some slack" (2012)

Cloud-based data management platforms often employ multitenant databases, where service providers achieve economies of scale by consolidating multiple tenants on shared servers. In such database systems, a key functionality for service providers is database migration, which is useful for dynamic provisioning, load balancing, and system maintenance. Practical migration solutions have several requirements, including high availability, low performance overhead, and self-management. We present Slacker, an end-to-end database migration system at the middleware level satisfying these requirements. Slacker leverages off-the-shelf hot backup tools to achieve live migration with effectively zero down-time. Additionally, Slacker minimizes the performance impact of migrations on both the migrating tenant and collocated tenants by leveraging 'migration slack', or resources that can be used for migration without excessively impacting query latency. We apply a PID controller to this problem, allowing Slacker to automatically detect and exploit migration slack in real time. Using our prototype, we demonstrate that Slacker effectively controls interference during migrations, maintaining latency within 10% of a given latency target, while still performing migrations rapidly and efficiently.
Optimal Use of Adhesive Layers in Reducing Impact Damage in Composite Laminates (1990)

Impact experiments were conducted on a group of cross-ply graphite/ epoxy laminates with and without adhesive layers. Impact-damage modes were examined by sectioning the impacted specimens and examining the sections with optical microscope. The effectiveness of using adhesive layers to suppress impact-induced delamination was investigated. It was found that the presence of adhesive layers could toughen the interface between two laminas and also reduce matrix cracking. A guide to optimal use of adhesive layers for improving impact resistance properties was proposed.
Pervaporation via silicon‐based membranes: Correlation and prediction of performance in pervaporation and gas permeation (2021)

Abstract Pervaporation (PV) is a membrane technology that holds great promise for industrial applications. To better understand the PV mechanism, PV dehydrations of various types of organic solvents (methanol, ethanol, iso‐propanol, tert‐butanol, and acetone) were performed on five types of organosilica and two types of silicon carbide‐based membranes, all with different pore sizes. Water permeance was dependent on the types of organic aqueous solutions, which suggested that organic solvents penetrated the pores and hindered the permeation of water. In addition, water permeance of various types of membranes in PV was well correlated with hydrogen permeance in single‐gas permeation. Furthermore, a clear correlation was obtained between the permeance ratio in PV and that in single‐gas permeation, which was confirmed via the modified‐gas translation model. These correlations make it possible to use single‐gas permeation properties to predict PV performance.
The Use of Percutaneous Nephrostomy and Urinary Alkalinization in the Dissolution of Obstructing Uric Acid Stones (1978)

Two patients are described who presented with complete urinary obstruction secondary to nonopaque uric acid stones. They were treated with percutaneous nephrostomy for urinary diversion and urinary alkalinization by local irrigation and oral sodium bicarbonate therapy with complete dissolution of the stone after 16 and 21 days of therapy. Percutaneous nephrostomy with urinary alkalinization is a reasonable, relatively safe alternative to surgical stone removal for patients with obstructing uric acid stones.
Quenching of High Temperature Cylindrical Surface with an Impinging Jet(Resident Time and Wetting Temperature) (2005)

An experiment study has been conducted to elucidate characteristics of transient heat transfer during quenching a hot cylindrical block with an impinging water jet. The experiment was done at atmospheric pressure for the following condition : an initial block temperature of 250 to 400°C, a subcooling of 5-80 K, a jet velocity of 3 15 m/s, and a nozzle diameter of 2 mm. It is observed that in a certain case the hot surface is hardly wetted immediately after the water jet impinges on it. After some times named resident time, the wetting of the surface starts and the position of wetting moves forwards. The quench of the hot block also starts with the movement of the wetting position. The resident time when the wetting location starts spreading after the jet impingement is one of the most importance and can be predicted by a proposed correlation. In addition, a correlation to predict the surface temperature at the resident time is proposed.
X-ray study of the incommensurate phase of (1999)

The successive structural phase transitions in the layer compound have been studied using single-crystal x-ray diffraction. The intermediate phase between 194 K and 214 K is found to be incommensurate; the satellite maps show that the modulation mode which characterizes the intermediate phase has . It is shown that the previously reported satellite reflections at are ascribable to twins. A structure model is presented for the incommensurate phase. In the low-temperature phase below 197 K, the satellite reflections are shifted to a commensurate position, .
Development of an alkaline fuel cell stack with bipolare configuration (2004)

Alkaline fuel cell stacks are mostly build in monopolare configuration of the cells. At the German Aerospace Center a bipolare plate for alkaline fuel cells was developed and characterized in a short stack. Caused by the sealing concept two different bipolare plate types are needed. Therefore, the number of cells can only varieties by 2 if the end plates are not changed. The single cell as well as the short stack was characterized by various methods. &#13;\nCaused by the used electrodes the differential pressure between electrolyte and gas phase must be limited to few of ten mbar. At higher differential pressures the gas crosses the electrode and penetrates the electrolyte or the electrolyte crosses the electrode and electrolyte comes into the flow fields. In contrast to PEFC, electrode supported by a metal net as conductor and mechanical support can be used in the AFC. Therefore, the structure of the flow field can be crude, this means width and deep canals are possible. Consequently, the pressure loss over the flow field is very low. &#13;\nThe single cell as well as the short stack was operated at pressures few ten mbar about the normal pressures. This fact allows to operate the AFC without a compression but with a simple fan.&#13;\nThe developed cell design is also used for the characterization of the fuel cell components like electrodes and diaphragms. The test facility for the single cell and for the stack is full computer controlled and allows the variation of the operation conditions, e.g. flow of the electrolyte, hydrogen flow, oxygen or air flow and cell temperature. &#13;\n
Nano-Desorption Electrospray and Kinetic Method in Chiral Analysis of Drugs in Whole Human Blood Samples (2008)

A home-made nano-desorption electrospray ionization (nano-DESI) device and the kinetic method were tested in chiral analysis of model clinical samples containing enantiomers of one of three pharmaceutically important compounds: dihydroxyphenylalanine (DOPA), ephedrine and ibuprofen. The initial evaluation of chiral systems was carried out by direct infusion of solution mixtures (analyte/central metal/chiral reference ligand) to a standard electrospray ionization (ESI) source. Cu(II) was used as a central metal for all analytes, L-phenylalanine was applied as a chiral reference ligand for DOPA, whereas L-tryptophan was used for the other two analytes. Then, the ESI source was substituted by a nano-DESI source and dried spots of 1 microL samples of whole human blood spiked with individual drugs were successfully analyzed without any pre-treatment. Irrespective of a laborious initial nano-DESI set-up, the combination of the kinetic method with nano-desorption electrospray has, for the first time, been demonstrated as a promising tool for chiral analysis of drugs in blood samples.