gebhart/patrepeval huggingface dataset:
Critical parameters for high-performance dynamic response measurements (2002)

The authors define several critical parameters required for accurate dynamic response time measurements on an ATE (automatic test equipment) system. They describe how these parameters were optimized on a high-performance pin electronics board through careful circuit design and a custom analog comparator IC design. They also outline the resulting performance of these parameters following the design changes. It is shown that the two key dynamic response parameters of an ATE system to evaluate are the overall system response bandwidth and the narrow-pulse performance parameters, as they include in their characterization almost all the critical dynamic response parameters. These two parameters, when evaluated on low-amplitude high-speed technologies, such as GaAs and ECL (emitter-coupled logic), provide the user with the clearest representation of a systems: dynamic response performance under actual operating conditions. When special attention is paid to these parameters in the design of an ATE system, as in the high-performance pin electronics card, a high-performance design capable of testing the most demanding high-speed technologies results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
MIRRAGGE – Minimum Information Required for Reproducible AGGregation Experiments (2020)

Reports on phase separation and amyloid formation for multiple proteins and aggregation-prone peptides are recurrently used to explore the molecular mechanisms associated with several human diseases. The information conveyed by these reports can be used directly in translational investigation, e.g., for the design of better drug screening strategies, or be compiled in databases for benchmarking novel aggregation-predicting algorithms. Given that minute protocol variations determine different outcomes of protein aggregation assays, there is a strong urge for standardized descriptions of the different types of aggregates and the detailed methods used in their production. In an attempt to address this need, we assembled the Minimum Information Required for Reproducible Aggregation Experiments (MIRRAGGE) guidelines, considering first-principles and the established literature on protein self-assembly and aggregation. This consensus information aims to cover the major and subtle determinants of experimental reproducibility while avoiding excessive technical details that are of limited practical interest for non-specialized users. The MIRRAGGE table (template available in Supplementary Information) is useful as a guide for the design of new studies and as a checklist during submission of experimental reports for publication. Full disclosure of relevant information also enables other researchers to reproduce results correctly and facilitates systematic data deposition into curated databases.
Dimensional Accuracy of Thermoset Composites: Shape Optimization (2002)

We present a design sensitivity analysis, which supports the shape optimization of the tool used in thermoset composite manufacturing. The method provides a systematic way to predict the optimal tool geometry that leads to the minimum difference between desired and final shapes of the manufactured part. The design process is formalized by integrating process modeling, design sensitivity analysis, and numerical optimization into a single framework. The process modeling is based on a transient coupled thermo-chemo-viscoelastic finite element scheme, which accurately capturest he evolution of residual stresses throughout the manufacturing process, and their effect on the final shape of the composite part. Design sensitivity information is extracted efficiently from the primal analysis using an analytical, direct differentiation method. The sensitivities are then provided to a numerical optimization program to improve the tool design. Optimization results are presented for two specific applications involving mold design for cross-ply laminates and L-shaped composite parts.
Transmitter Precoding with Reduced-Complexity Soft Detection for MIMO Systems (2007)

We present a preceded reduced-complexity soft detection (PRCSD) algorithm for multiple-input multiple-output (MIMO) systems. The linear operations at both transmit and receive sides based on complex Householder transform convert the MIMO channel to be multiple-diagonal, spatially partial-response-like, so that error propagation is alleviated when applying reduced-complexity soft detection at the receiver. The transform results in unitary precoding and feedforward matrices so that neither transmit power boost nor noise enhancement is present. Performance analysis based on pairwise error probability (PEP) shows that PRCSD achieves larger diversity advantage than existing preceding and multiple-beamforming (MB) schemes, which basically attempt to transmit signals through diagonal independent sub-channels and thus may suffer a diversity loss. PRCSD can achieve full diversity as maximum likelihood (ML) detection in some scenarios while reducing complexity significantly
Retinoic acid/calcite micro-carriers inserted in fibrin scaffolds modulate neuronal cell differentiation (2019)

The controlled release of cell differentiating agents is crucial in many aspects of regenerative medicine. Here we propose the use of hybrid calcite single crystals as micro-carriers for the controlled and localized release of retinoic acid, which is entrapped within the crystalline lattice. The release of retinoic acid occurs only in the proximity of stem cells, upon dissolution of the calcite hybrid crystals that are dispersed in the fibrin scaffold. These hybrid crystals provide a sustained dosage of the entrapped agent. The environment provided by this composite scaffold enables differentiation towards neuronal cells that form a three-dimensional neuronal network.
Patterns of major wound complications following multidisciplinary therapy for lower extremity soft tissue sarcoma (2016)

A considerable proportion of MWCs occur >120 days from surgical resection with preoperative EBRT and skin graft placement independent predictors for MWCs. While an additional source of morbidity, MWC occurrence did not impact tumor control, nor did it predict for chronic toxicity. J. Surg. Oncol. 2016;114:385-391. © 2016 Wiley Periodicals, Inc.
Extracellular Vesicles as an Endocrine Mechanism Connecting Distant Cells (2022)

The field of extracellular vesicles (EVs) has expanded tremendously over the last decade. The role of cell-to-cell communication in neighboring or distant cells has been increasingly ascribed to EVs generated by various cells. Initially, EVs were thought to a means of cellular debris or disposal system of unwanted cellular materials that provided an alternative to autolysis in lysosomes. Intercellular exchange of information has been considered to be achieved by well-known systems such as hormones, cytokines, and nervous networks. However, most research in this field has searched for and found evidence to support paracrine or endocrine roles of EV, which inevitably leads to a new concept that EVs are synthesized to achieve their paracrine or endocrine purposes. Here, we attempted to verify the endocrine role of EV production and their contents, such as RNAs and bioactive proteins, from the regulation of biogenesis, secretion, and action mechanisms while discussing the current technical limitations. It will also be important to discuss how blood EV concentrations are regulated as if EVs are humoral endocrine machinery.
Genetic variability of potato spindle tuber viroid RNA replicon. (2001)

The genetic continuity of the potato spindle tuber viroid (PSTVd) genome was analysed after infection of tomato plants with cloned cDNAs of parental strains. During the six weeks of the experiment, several new sequence variants appeared. The sequence variants detected in the progeny population induced sequence-specific disease symptoms. The PSTVd genome therefore follows the pattern expected for typical pseudo-strains propagating in plants as a population of similar sequences. Assessing further the replicon continuity, a PSTVd cDNA mutant with a deletion in the central conserved region was constructed and proven to be non-infectious. Surprisingly, in a sub-population of potato transformants expressing the same deleted PSTVd RNA an infectious viroid was detected. This suggests specific transcript conversion followed by recovery of the full-length pathogen genome.
Measurement and analysis of intra-vehicle UWB channels (2013)

In this paper, the effects of the transceiver distance on the number of multipath components (MPCs), received power, maximum delay spread, and root mean squared delay spread of intra-vehicle ultra wideband (UWB) propagation channels are investigated through analyzing data obtained from field measurements. Moreover, statistical models are established to describe the behavior of those parameters as a function of distance. Analysis results show that there is a noticeable correlation between the parameters and transceiver distance. However, the average to standard deviation ratio of the measured data reveals that these parameters are very slowly decreasing with distance. This study demonstrates the robustness of intra-vehicle UWB channels against transceiver distance. Therefore, UWB technology is promising to be used for intra-vehicle wireless communication and control systems.
A Platform for Developing Robotic Navigation Strategies in a Deformable, Dynamic Environment (2018)

While in vivo robotic locomotion has demonstrated its potential through a number of means, sensing and closed-loop control for such devices have not been at the forefront of research. By enabling real-time navigation, capsule endoscopy could transform from passive capsule endoscopes (CEs) and remote-controlled robotic CE devices into semi- or fully autonomous, surgical tools. In this work, a novel robotic endoscope platform (REP) is designed and tested. This platform will be used to evaluate control, localization, and mapping techniques necessary to endow a robotic CE with autonomous features. REP performance was benchmarked against design requirements that included sensing, speed, and maneuverability. It was found that the REP could accelerate to a maximum speed of 80 mm/s in less than 0.2 s and could achieve a zero-point turning radius. Most significantly, a low-cost image segmentation algorithm was developed to enable real-time lumen navigation/center tracking. Visual navigation time trials were compared to manual user trials through a 90-degree turn in a deformable simulator, exhibiting mean run times 34% faster than manual users. This demonstrates the REP's maneuverability and sensing capabilities allowing for future implementation of a range of advanced sensing and control techniques ahead of robotic CE adoption.
A continuous single organic phase process for the lipase catalyzed synthesis of peroxy acids increases productivity (2017)

The design of an optimal process is particularly crucial when the reactants deactivate the biocatalyst. The reaction cascades of the chemo-enzymatic epoxidation where the intermediate peroxy acid is produced by an enzyme are still limited by enzyme inhibition and deactivation by hydrogen peroxide. To avoid additional effects caused by interfaces (aq/org) and to reduce the process limiting deactivation by the substrate hydrogen peroxide, a single-phase concept was applied in a fed-batch and a continuous process (stirred tank), without the commonly applied addition of a carrier solvent. The synthesis of peroxyoctanoic acid catalyzed by <i>Candida antarctica</i> lipase B was chosen as the model reaction. Here, the feasibility of this biocatalytic reaction in a single-phase system was shown for the first time. The work shows the economic superiority of the continuous process compared to the fed-batch process. Employing the fed-batch process reaction rates up to 36 mmol h<sup>-1</sup> per gram<sub>cat</sub>, and a maximum yield of 96 % was achieved, but activity dropped quickly. In contrast, continuous operation can maintain long-term enzyme activity. For the first time, the continuous enzymatic reaction could be performed for 55 h without any loss of activity and with a space-time yield of 154 mmol L<sup>-1</sup> h<sup>-1</sup>, which is three times higher than in the fed-batch process. The higher catalytic productivity compared to the fed-batch process (34 vs. 18 g<sub>Prod</sub> g<sup>-1</sup> <sub>cat</sub>) shows the increased enzyme stability in the continuous process.
A nuclear DNA-binding protein expressed during early stages of B cell differentiation interacts with diverse segments within and 3’ of the Ig H chain gene cluster (1992)

We have used electrophoretic mobility shift assays (EMSA) to detect B cell lineage-specific nuclear proteins that bind to diverse segments within and 3' of the Ig H chain gene cluster. DNA binding sites include sequences 5' of each of the following C region genes: mu, gamma 1, gamma 2a, epsilon, and alpha. For the most part, these binding sites lie 5' of CH-associated tandem repeats. Binding sites for the same B cell lineage-specific proteins have also been defined in the region 3' of C alpha, close to a recently described B cell-specific enhancer element. Cross-competition of EMSA indicates that the B cell lineage-specific nucleoprotein is indistinguishable from those described previously by others: S alpha-BP and BSAP. Because of the diverse sequences recognized by this protein, we term it NF-HB, B-lineage-specific nuclear factor that binds to Ig H gene segments. EMSA using segments 5' of S gamma 2a (5'S gamma 2a-176) and 3' of C alpha (3' alpha-88) shows multiple binding complexes, two of which are B cell lineage specific. The B cell-specific complex with fastest mobility contains only NF-HB, and the one with slowest mobility contains NF-HB together with a ubiquitous DNA-binding protein(s). The ubiquitous binding protein is different for 5' S gamma 2a-176 and for 3' alpha-88, representing the formation of protein-NF-HB complexes specific for these particular Ig DNA regions. Spleen cells show a single band upon EMSA with either 5'S gamma 2a-176 or 3' alpha-88. Upon LPS stimulation, additional binding complexes of slower mobility were formed resulting in a pattern comparable to those detected in pro-B, pre-B, and B cell lines. We hypothesize that NF-HB may promote physical interactions between the 3' alpha-enhancer and segments of the Ig H gene cluster.
The future of maglev (2007)

This paper presents a personal opinion concerning the future potential for maglev and linear motor technology to create improved transportation systems for a wide range of applications.
Structure from stereo-a review (1989)

The authors review major recent developments in establishing stereo correspondence for the extraction of the 3D structure of a scene. Broad categories of stereo algorithms are identified on the basis of differences in imaging geometry, matching primitives, and the computational structure used. The performance of these stereo techniques on various classes of test images is reviewed, and possible directions of future research are indicated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Designing F# Libraries (2012)

This book deals with F#, a language situated in the context of .NET-based software construction and engineering. As an expert F# programmer, you need more than knowledge of the F# language; you also need to use a range of software-engineering tools and methodologies wisely to build software that is truly valuable for the situation for which it's deployed. The previous chapter touched on some important tools. This final chapter looks at some of the methodological issues related to F# library design, including: Designing vanilla .NET libraries that minimize the use of F#-specific constructs, according to existing .NET design conventions Elements of functional programming design methodology, which offers important and deep insights into programming, but doesn't address several important aspects of the library or component design problems Specific suggestions for designing .NET and F# libraries, including naming conventions, how to design types and modules, and guidelines for using exceptions
Phosphorene as an Anode Material for High Performance Lithium-Ion Battery: First Principle Study and Experimental Measurement (2016)

The prospects of phosphorene as an anode material for high performance Li-ion battery was systematically investigated from the first principle calculations and experimental measurements. The diffusion energy barriers of a Li atom moving along various orientations on phosphorene layer were calculated from the Li adsorption energy landscape. It was found that the diffusion mobility of a Li atom along the zigzag direction in the valley of phosphorene could be about 7 to 11 orders of magnitude faster than that along the other directions, indicating its ultrafast and anisotropic diffusivity. The lithium insertion in phosphorene was studied considering various LinP16 configurations (n=1~16). It was found that phosphorene could accommodate up to one Li per P atom (i.e., Li16P16), and the predicted theoretical value of the Li capacity for a single layered phosphorene can reach about 865 mAh/g. Our experimental measurement on the Li capacity for a network of a few layered phosphorene can reach a reversible stable value of ~ 453 mAh/g even after 50 cycles. In particular, it was found that, even at the high Li concentration (e.g., x = 1 in LixP), there was no Li clustering and the structure of phosphorene is reversible during the lithium intercalation. Our results clearly show that phosphorene has promise as a novel anode material for high performance Li-ion batteries.
Secrecy Capacity of Semi-deterministic Wire-tap Channels (2007)

This paper studies secrecy capacity in a semi-deterministic setting, in which the channel between legitimate users (called Alice and Bob) is deterministic, while that between Alice and the eavesdropper (called Eve) is a discrete memoryless channel. Such a model is particularly relevant when a pre-existing error correcting code tailored to the legitimate channel is in use on top of which secret information is to be shared. First, a point-to-point setting is considered with a single wiretapper, a situation in which the secrecy capacity has an elegant characterization. Next, a generalized multiple access setting with confidential messages is considered in which each user wishes to communicate secret information to a common destination without the other determining its message. In this latter situation, outer bounds on the secrecy capacity are obtained.
Drug Design and the Male Ego (2009)

Kerry Fowler, medicinal chemist and industry consultant, formerly of G.D. Searle and the late ICOS corporation will join us to talk about medicinal chemistry, drug design and his role in the development of Cialis, the erectile dysfunction drug.
Ultra-low latency recurrent neural network inference on FPGAs for physics applications with hls4ml (2022)

Recurrent neural networks have been shown to be effective architectures for many tasks in high energy physics, and thus have been widely adopted. Their use in low-latency environments has, however, been limited as a result of the difficulties of implementing recurrent architectures on field-programmable gate arrays (FPGAs). In this paper we present an implementation of two types of recurrent neural network layers -- long short-term memory and gated recurrent unit -- within the hls4ml framework. We demonstrate that our implementation is capable of producing effective designs for both small and large models, and can be customized to meet specific design requirements for inference latencies and FPGA resources. We show the performance and synthesized designs for multiple neural networks, many of which are trained specifically for jet identification tasks at the CERN Large Hadron Collider.
MRI assessment of treatment delivery for interstitial photodynamic therapy of high‐grade glioma in a preclinical model (2017)

Diffusion and perfusion MRI revealed histological lesions. Interstitial PDT (iPDT) induced specific lesions in the tumor tissue, which were observed with MRI and confirmed by histopathological analysis. Thus, MRI may provide a non-invasive and reliable tool to assess treatment outcomes after PDT. Lasers Surg. Med. 50:460-468, 2018. © 2017 Wiley Periodicals, Inc.
Physiologically Relevant Oxidative Degradation of Oligo(proline) Cross-Linked Polymeric Scaffolds (2011)

Chronic inflammation-mediated oxidative stress is a common mechanism of implant rejection and failure. Therefore, polymer scaffolds that can degrade slowly in response to this environment may provide a viable platform for implant site-specific, sustained release of immunomodulatory agents over a long time period. In this work, proline oligomers of varying lengths (P(n)) were synthesized and exposed to oxidative environments, and their accelerated degradation under oxidative conditions was verified via high performance liquid chromatography and gel permeation chromatography. Next, diblock copolymers of poly(ethylene glycol) (PEG) and poly(ε-caprolactone) (PCL) were carboxylated to form 100 kDa terpolymers of 4%PEG-86%PCL-10%cPCL (cPCL = poly(carboxyl-ε-caprolactone); i% indicates molar ratio). The polymers were then cross-linked with biaminated PEG-P(n)-PEG chains, where P(n) indicates the length of the proline oligomer flanked by PEG chains. Salt-leaching of the polymeric matrices created scaffolds of macroporous and microporous architecture, as observed by scanning electron microscopy. The degradation of scaffolds was accelerated under oxidative conditions, as evidenced by mass loss and differential scanning calorimetry measurements. Immortalized murine bone-marrow-derived macrophages were then seeded on the scaffolds and activated through the addition of γ-interferon and lipopolysaccharide throughout the 9-day study period. This treatment promoted the release of H(2)O(2) by the macrophages and the degradation of proline-containing scaffolds compared to the control scaffolds. The accelerated degradation was evidenced by increased scaffold porosity, as visualized through scanning electron microscopy and X-ray microtomography imaging. The current study provides insight into the development of scaffolds that respond to oxidative environments through gradual degradation for the controlled release of therapeutics targeted to diseases that feature chronic inflammation and oxidative stress.