gebhart/patrepeval huggingface dataset:
Cis/Trans Isomerization and Conformational Properties of 2,4-Bis(primary amino)-1,3,2,4-Diazadiphosphetidines (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCis/Trans Isomerization and Conformational Properties of 2,4-Bis(primary amino)-1,3,2,4-DiazadiphosphetidinesTara G. Hill, R. Curtis Haltiwanger, Martin L. Thompson, Stephanie A. Katz, and Arlan D. NormanCite this: Inorg. Chem. 1994, 33, 9, 1770–1777Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/ic00087a009https://doi.org/10.1021/ic00087a009research-articleACS PublicationsRequest reuse permissionsArticle Views257Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
From Region Features to Semantic Labels: a Probabilistic Approach. (2003)

This paper presents a novel method of semantic labeling that can assign multiple semantic labels to a region along with the con dence measures of the assignment. Unlike existing classi cation methods, it can learn to perform semantic labeling incrementally. Test results show that the method is eective and accurate in labeling a wide variety of regions
On the Prediction of non-CG DNA Methylation (2022)

Abstract DNA cytosine methylation is an epigenetic modification that has a critical role in gene regulation and genome stability. DNA methylation can be detected and measured using sequencing instruments after sodium bisulfite conversion, but experiments can be expensive for large eukaryotic genomes. Sequencing non-uniformity and mapping biases can leave parts of the genome with low or no coverage, thus hampering the ability of obtaining DNA methylation levels for all cytosines. To address these limitations, several computational methods have been proposed that can predict DNA methylation from the DNA sequence around the cytosine, or from the methylation level of nearby cytosines. Most of these methods are, however, entirely focused on CG methylation in humans and other mammals. In this work, we study for the first time the problem of predicting cytosine methylation for CG, CHG, and CHH contexts on five plant species, either from the DNA primary sequence around the cytosine or the methylation levels of neighboring cytosines. In this framework, we also study (1) the cross-species prediction problem, i.e., the classification performance when training on one species and testing on another species, and the (2) the cross-context prediction problem, i.e., the classification performance when training on one context and testing on another context (within the same species). Finally, we show that providing the classifier with gene annotation information allows our classifier to outperform the prediction accuracy of state-of-the-art methods.
Cytotoxic 6-Substituted 5,6-Dihydro-2H-pyran-2-ones from a Brazilian Medicinal Plant, Chorisia crispiflora (1994)

Three cytotoxic 6-substituted 5,6-dihydro-2H-pyran-2-ones ( 1 -3) were ~solated from a Brazilian medicinal plant, Chorisia crispiflora. 1 was identlfred as argentilactone, and the structures of two new compounds (2 and 3) were determined on the basis of the physicochemical properties.In the course of our program to isolate new biologically actlve compounds from Brazilian medicinal plants,' the methanol~c extract of Chorisia crispiflora (Bombacaceae) ("lnvira-tanha" or "Paine~ra" In Braz~l), one of the folk medicines used for rheumatism and menorrhalgia, was found to show a strong cytotoxic actlvtty against P-388 mouse leukernla cells.The invest~gatlon on the active princ~ples led to the ~solatlon of three cytotoxic compounds.In t h ~s paper, we report the ~solatlon and structure determinat~on of these compounds.The methanolic extract of the leaves of C. crispiflora was extracted w~th EtOAc and n-BuOH.A large portion of the cytotoxic activity passed into the EtOAc fraction, wh~ch was subjected to column chromatography on sllica gel repeatedly to afford compounds I, 11, and Ill.Compound I (1).[a], -18.O0(c 0.82, CHCIJ, was isolated as colorless 011, and the molecular formula C,,H,,O, was established by the HREl ms (m/z 194.1314,M' ) and ' ' C nmr spectrum.'The 'H nmr spectrum of 1 (Table )3 exhib~ted signals due to a primary methyl group (6 0.89), five methylene groups (6 1.20 -2.40), a methine group ( 6 5.22).a cis double bond ( 6 5.56 and 6 5.66).and an enone group (6 6.05 and 6 6.90).Analys~s of 'H-'H and 'H-"C COSY spectra of 1 revealed the connect~on of all signals to give the partial structure A.
The Design of Intelligent Home Furnishing System of Internet of Things (2014)

Through the market investigation was designed based on the environmental monitoring system, intelligent control system and simulation system of security system, intelligent Home Furnishing system, this system uses CC2530 and sensors to build a ZigBee network, and realizes the remote monitoring through GPRS module, configuration of the PC software for the system, realized the function of intelligent furniture system through the actual test, that, the system is stable and reliable, practical.
Measurement of Small-Scale Density Fluctuation in JIPP T-II Plasma by Millimeter and Sub-Millineter Wave Scattering (1983)

The small-scale density fluctuations have been studied by both millimeter (2 mm) and sub-millimeter (337 µm) wave scattering technique in JIPP T-II plasmas. Experiments were performed in two types of plasma: tokamak and stellarator plasmas. In both plasmas, the density fluctuations are localized in outer region of the plasma column, and show the characteristics of the drift wave mode turbulence. The density fluctuation level is \(\tilde{n}/n_{0}{\simeq}1{-}1.5\%\) around the plasma edge, and this value is inversely proportional to the mean electrondensity. Further, the dependence of the fluctuation level on the plasma parameters is studied and compared with the scaling law of the energy confinement time of the plasma. The diffusion coefficient estimated from the density fluctuation is about one third of the global diffusion coefficient.
Impact of the National Breast and Cervical Cancer Early Detection Program on mammography and pap test utilization among white, Hispanic, and African American women: 1996–2000 (2006)

Prevention, including routine cancer screening, is key to meeting national goals for the elimination of death and suffering due to cancer. Since 1991, the U.S. government has invested in programs such as the National Breast and Cervical Cancer Early Detection Program (NBCCEDP) to detect breast and cervical cancer early among uninsured low-income women. A concomitant goal is reducing racial disparities in screening and early detection, and the NBCCEDP program targets low-income women who are more often racial and ethnic minorities. This paper analyzes data to test for effects of the NBCCEDP and other determinants of screening across racial/ethnic groups. We used data from the Behavioral Risk Factor Surveillance System (BRFSS) for 1996 through 2000. These data indicate that gaps in testing for breast and cervical cancers between African American and non-Hispanic white women aged 40-64 years have closed but remain for Hispanics. Multivariate findings indicate that the longevity of free screening sites through the NBCCEDP significantly increased both tests for non-Hispanic white women. The data do not confirm this effect for other racial and ethnic groups. Analysis did indicate that public insurance, or Medicaid, was equal to private insurance in promoting increased testing for African Americans and Hispanics, but not for non-Hispanic whites. Assuring that Medicaid remains available for women in this nonelderly group and increasing access to free screening sites can lead us closer to national screening goals, yet policies still need to address racial/ethnic disparities in insurance and service delivery. Cancer 2007. (c) 2006 American Cancer Society.
Distinct Types of Fibrocyte Can Differentiate from Mononuclear Cells in the Presence and Absence of Serum (2010)

These data show that SF and SC fibrocytes are distinct but related cell types, and suggest that they will play different roles during tissue repair and fibrosis where changes in serum proteins may occur.
Effectiveness of omega-3 fatty acid supplementation in patients with Alzheimer disease: A systematic review and meta-analysis (2020)

Alzheimer disease (AD) is a neurodegenerative disease characterised by progressive dementia associated with global cognitive dysfunction. We conducted a systematic review and meta-analysis of clinical trials evaluating omega-3 supplementation in patients with AD. To determine if there is scientific evidence of the effectiveness of omega-3 supplementation in improving cognitive function in patients with AD. We included only randomised controlled trials (RCTs) from the following databases: Medline, Cochrane Central, Cinahl, and LILACS. An electronic search was also conducted using Google Scholar. Six articles met the eligibility criteria. The risk of bias was assessed following the Cochrane method. There is no consistent evidence to support the effectiveness of omega-3 supplementation in improving cognitive function in AD patients in the short and medium term. La enfermedad de Alzheimer (EA) es una patología neurodegenerativa caracterizada por demencia de carácter progresivo asociada a una perdida global de funciones cognitivas. Se realizó una síntesis de evidencia a través de una revisión sistemática con metaanálisis de ensayos clínicos que hayan evaluado la suplementación de omega-3 en pacientes con EA. Determinar si existe evidencia científica que avale la efectividad de la suplementación omega-3 en la mejoría de la función cognitiva de pacientes con EA. La estrategia de búsqueda incluyó solo ensayos clínicos aleatorizados (ECA). Las bases de datos usadas fueron: Medline, Cochrane Central, Cinahl y Lilacs. Además, se realizó una búsqueda electrónica en Google Scholar. Se obtuvieron 6 artículos que cumplían con nuestros criterios de elegibilidad. Se evaluó el riesgo de sesgo según el método Cochrane. No hay evidencia consistente que avale la suplementación de omega-3 versus placebo en la mejoría de la función cognitiva de pacientes con EA a corto y mediano plazo.
A Highly Restricted T-Cell Receptor Dominates the CD8+T-Cell Response to Parvovirus B19 Infection in HLA-A*2402-Positive Individuals (2006)

Six of seven HLA-A*2402-positive individuals with acute parvovirus B19 infections made vigorous CD8-positive cytotoxic T-cell (CTL) responses to the viral epitope FYTPLADQF. All responders showed highly focused T-cell receptor (TCR) usage, using almost exclusively BV5.1. The BV5.1 TCR dominated the acute response, was maintained over time, and was also used by a remotely infected individual. Nine CTL clones and two oligoclonal lines obtained from three unrelated individuals used BV5.1, BJ2.1, and a conserved TCR CDR3 of nine amino acids. This commonly recognized epitope is likely important in long-term protective immunity and should be included in vaccine design.
Cop9 signalosome subunit 8 (CSN8) is essential for Drosophila development (2008)

The COP9 signalosome (CSN) is a multisubunit regulator highly conserved in evolution. We show here that CSN subunit 8 (CSN8) is essential for Drosophila development. CSN8 is maternally contributed and present throughout development. Null mutants generated in this study are larval lethal, showing phenotypes associated with mutations in either CSN4 (molting defects) or CSN5 (melanotic tumors). Analysis of mitotic and germ-line csn8(null) clones revealed the requirement of CSN8 for multiple developmental processes. The germ-line clones arrested at mid-oogenesis, while the mitotic clones led to deformed adult eyes or wings. CSN8 is present exclusively as part of the CSN holo-complex, and lack of CSN8 in the mutants leads to CSN instability. Consistent with this, Cullin deneddylation is impaired in the csn8(null) mutants.
Pain management in the community (1998)

Managing pain is about far more than the administration of analgesics. Gilly Burn explains the importance of a holistic approach.
Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cells (2009)

Selectins facilitate metastasis and tumor cell arrest in the microvasculature by mediating binding of selectin-expressing host cells to ligands on tumor cells. We recently identified CD44 variant isoforms as functional P-, but not E-/L-, selectin ligands on colon carcinoma cells. Furthermore, a approximately 180-kDa sialofucosylated glycoprotein(s) mediated selectin binding in CD44-knockdown cells. Using immunoaffinity chromatography and tandem mass spectrometry, we identify podocalyxin-like protein (PCLP) as an alternative selectin ligand. Blot rolling and cell-free flow-based adhesion assays disclose that PCLP on LS174T colon carcinoma cells possesses E-/L-, but not P-, selectin binding activity. The selectin-binding determinants on LS174T PCLP are non-MECA-79-reactive sialofucosylated structures displayed on O-linked glycans, distinct from the MECA-79-reactive O-glycans on PCLP expressed by high endothelial venules, which is an L-selectin ligand. PCLP on CD44-knockdown LS174T cells exhibits higher HECA-452 immunoreactivity than PCLP on wild-type cells, suggesting that PCLP functions as an alternative acceptor for selectin-binding glycans. The enhanced expression of HECA-452 reactivity on PCLP from CD44-knockdown cells correlates with the increased avidity of PCLP for E- but not L-selectin. The novel finding that PCLP is an E-/L-selectin ligand on carcinoma cells offers a unifying perspective on the apparent enhanced metastatic potential associated with tumor cell PCLP overexpression and the role of selectins in metastasis.
Resistance thermometry-based picowatt-resolution heat-flow calorimeter (2013)

We demonstrate a microfabricated heat-flow calorimeter capable of measuring modulated heat currents with ∼5 pW resolution. This is achieved by combining the excellent thermal isolation of a microdevice suspended by thin and long beams (conductance ∼150 nW/K) with a high-resolution resistance thermometer that enables temperature measurements with 10–50 μK resolution [Sadat et al., Rev. Sci. Instrum. 83(8), 084902 (2012)). The calorimeter described here has a resolution comparable to state-of-the-art bimaterial cantilever-based calorimeters but surpasses previous designs by dissipating an order of magnitude lower power in the measurement process.
Aerodynamic Three-Axis Attitude Stabilization of a Spacecraft by Center-of-Mass Shifting (2017)

This paper proposes a spacecraft attitude control technique based on the use of center-of-mass shifting. In particular, the position vector of the spacecraft’s center of pressure with respect to the center of mass is modified by shifting masses, which results in a change of the aerodynamic torque vector within the plane perpendicular to the aerodynamic drag. This results in an underactuated control system. To achieve full three-axis stabilization, additional actuators (either a reaction wheel or a set of magnetic torquers) are considered. An adaptive nonlinear attitude regulation control law was designed in order to obtain an ideal control torque based on the Lyapunov method and its stability was proven by LaSalle’s invariance principle. The control torque was then allocated to steer three shifting masses and either a reaction wheel or three magnetic torquers. Numerical simulations are reported, confirming the analytic results. The proposed method decreases the residual oscillation error typically associated with magnetic controlled attitude in the presence of residual aerodynamic torque. Therefore, it might contribute to achieve higher pointing accuracy of small spacecraft in low Earth orbit.
THIXOTROPY: THE EFFECT OF STIMULATION IN FROG MUSCLE (1988)

Recent reports have shown that the stiffness of relaxed frog muscle is not a fixed property, but is dependent on the previous history of movement (Lakie & Robson, 1988a). Passive movement decreases stiffness; when the muscle is subsequently allowed to rest it returns at a progressively declining rate to a level of stiffness that is close to its original value (Lakie & Robson, 1988b). We now report that the stiffness of relaxed muscle is also affected by prior tetanic electrical stimulation under isometric conditions. The effect of electrical stimulation is similar to passive movement in that both produce a temporary decrease in stiffness.
An analysis of the relative effects of VKORC1 and CYP2C9 variants on anticoagulation related outcomes in warfarin-treated patients (2008)

The objective of this study was to assess the relative influence of VKORC1 and CYP2C9 genetic variants on several clinical outcomes related to warfarin treatment. We conducted a retrospective cohort analysis of 172 anticoagulation clinic patients followed from warfarin initiation. We assessed the following clinical outcomes: time to stable dose; time in, above, and below therapeutic range; the probability of overanticoagulation (international normalized ratio [INR] >5); frequency of anticoagulation clinic visits; and the contribution of genetics to maintenance dose. Patients with CYP2C9 variants, compared to those without, achieved stable dose 48% later (p < 0.01), spent a higher proportion of time above range in the first month of therapy (14% vs. 25%, p = 0.07), and had a higher odds ratio (OR) of an INR >5 (OR: 4.15, p = 0.03). In contrast, the only statistically significant effect with VKORC1 was a higher odds of an INR >5 (OR: 4.47, p = 0.03) for patients homozygous for the VKORC1 low-dose haplotype (AA) compared to heterozygotes. We did not detect an influence of CYP2C9 nor VKORC1 on the frequency of clinic visits. CYP2C9 alone, VKORC1 alone, and a combination of genetic and clinical factors explained 12%, 27%, and 50%, respectively, of the variation in warfarin maintenance dose. In conclusion, genetic variation in VKORC1 appears to have a different influence than CYP2C9 on anticoagulation-related outcomes such as bleeding events and time in therapeutic range. This difference may be due, in part, to pharmacokinetics factors (e.g. drug half-life), which are influenced primarily by CYP2C9; these findings should be confirmed in additional studies.
Retrospective Chart Review Study of Patients Receiving Serum-Derived Bovine Immunoglobulin/Protein Isolate (SBI) for Nutritional Management of Irritable Bowel Syndrome with Diarrhea (IBS-D) (2016)

Introduction: IBS-D is a common condition with few effective treatment options. The prescription medical food, SBI, has been shown to manage chronic loose and frequent stools in IBS-D patients. The safety and effectiveness of SBI as a therapy for IBS-D was further examined in this multi-center, IRB-reviewed study for overall and individual symptom response. Methods: Symptom data including stool frequency and consistency (Bristol Stool Scale 1-7), abdominal pain intensity (0 = no pain to 10 = worst pain) and adverse events (AEs) were collected from medical charts on 116 patients. Criteria for inclusion in primary analysis were patients having baseline recorded scores for stool consistency and abdominal pain, failure of standard-of-care (SOC) treatment, and not having received confounding IBS-D medications while on SBI. Results: The majority of patients who met criteria for analysis (n = 34) were white (94%), female (71%) with a median age of 53 (28, 85) and received SBI therapy for a mean duration of 23.2±24.1 wks [median 15.5 wks (0.4, 97.9)]. Mean baseline symptom scores were: stool frequency 5.24 (range 2 to 20); stool consistency 6.00 (range 4 to 7) and abdominal pain 4.56 (range 2 to 10). Twenty-five of the 34 patients had baseline abdominal pain scores >2 and stool consistency scores ≥ 5 to assess overall response; nine patients were excluded based on absence of pain (recorded score = 0) and normal stool score (Bristol Stool Scale = 4) at baseline. Of the 25 patients, 16 (64%) were responders with stool consistency < 5 and a 30% reduction in abdominal pain scores following SBI therapy. Using a generalized linear regression model for individual symptoms, the number of stools per day decreased by 3.24 (95% Confidence Interval (CI) 0.50, 5.98; P = 0.022), stool consistency improved by 1.86 (95% CI, 1.39, 2.33; P < 0.0001) and abdominal pain/discomfort intensity decreased by 3.03 (95% CI 1.668, 4.39; P < 0.0001). Thirteen of the 116 patients experienced one or more AEs while on SBI therapy. The main AEs were nausea (n = 5 patients) and an increase abdominal discomfort (n = 2 patients). No serious AEs were reported. Conclusion: Though retrospective, the inclusion criteria of SOC failure prior to SBI administration with demonstrated high combined abdominal pain and stool consistency response, as well as statistically significant individual symptom improvement, demonstrate SBI's clinical utility in IBS-D management. Additional chart reviews continue.
Outage Behavior of Slow Fading Channels With Power Control Using Partial and Erroneous CSIT (2010)

This work investigates high-SNR outage behavior of slow fading channels with quantized feedback and partial power control, when feedback indices are error-prone. We propose a quantizer structure with continuous Voronoi regions and derive its optimality conditions using probability analysis. Our design involves construction of a novel bit-mapping scheme. The optimized power control codebook resembles channel optimized scalar quantizers (COSQs). Also, the diversity gain of the communication system under study is characterized with both nonzero and vanishing feedback error probabilities.
Word Vector Embeddings and Domain Specific Semantic based Semi-Supervised Ontology Instance Population (2018)

An ontology defines a set of representational primitives which model a domain of knowledge or discourse. With the arising fields such as information extraction and knowledge management, the role of ontology has become a driving factor of many modern day systems. Ontology population, on the other hand, is an inherently problematic process, as it needs manual intervention to prevent the conceptual drift. The semantic sensitive word embedding has become a popular topic in natural language processing with its capability to cope with the semantic challenges. Incorporating domain specific semantic similarity with the word embeddings could potentially improve the performance in terms of semantic similarity in specific domains. Thus, in this study, we propose a novel way of semi-supervised ontology population through word embeddings and domain specific semantic similarity as the basis. We built several models including traditional benchmark models and new types of models which are based on word embeddings. Finally, we ensemble them together to come up with a synergistic model which outperformed the candidate models by 33% in comparison to the best performed candidate model.