gebhart/patrepeval huggingface dataset:
Evaluating and improving the robustness of a video-based PR/RR monitoring system for a clinical environment (2016)

With the advancement and use of low cost cameras, video-based remote vital-monitoring technologies have drawn more and more attention. However, many of the previously proposed techniques rely on the assumption that the video is acquired under well-controlled conditions. There has been no study reported around how various acquisition factors and/or noise will affect the estimation accuracy. In this paper, we describe a systematic approach in understanding the challenges of extending the technology beyond a well-controlled environment and share the solution paths in making the technology robust in one specific application. The systematic approach involves first understanding the data analysis process, identifying key factors that affect the algorithms and then estimating the bounds of the factors and metrics that explain the variations in these vitals. As part of the solution paths, our paper goes into the details of how the algorithms were improved to address the findings of the current state. The refinement in the algorithms includes getting stronger signals in less controlled setting.
Alsavine : Vers de nouvelles variétés de vignes pour une viticulture alsacienne durable (2012)

National audience
Reconstruction-Based Fault Identification Using a Combined Index (2001)

Process monitoring and fault diagnosis are crucial for efficient and optimal operation of a chemical plant. This paper proposes a reconstruction-based fault identification approach using a combined index for multidimensional fault reconstruction and identification. Fault detection is conducted using a new index that combines the squared prediction error (SPE) and T2. Necessary and sufficient conditions for fault detectability are derived. The combined index is used to reconstruct the fault along a given fault direction. Faults are identified by assuming that each fault in a candidate fault set is the true fault and comparing the reconstructed indices with the control limits. Fault reconstructability and identifiability on the basis of the combined index are discussed. A new method to extract fault directions from historical fault data is proposed. The dimension of the fault is determined on the basis of the fault detection indices after fault reconstruction. Several simulation examples and one practical c...
Ipratropium nasal spray: a new treatment for rhinorrhea in the common cold. (1981)

A need is often present for symptomatic treatment of the common cold. A blocked nose can be opened by a vasoconstrictor, but no effective therapy is known today for rhinorrhea. The aim of the present trial was to study the effect of the topically active parasympatholytic, ipratropium, on rhinorrhea. In a placebo-controlled group comparative trial, 80 micrograms of ipratropium were taken as a nasal spray 4 times daily for 1 wk by 40 adults with spontaneously occurring common colds. All subjects administered an intranasal vasoconstrictor (xylomethazoline, 0.1%) 5 min before administering placebo or ipratropium. Ipratropium treatment resulted in a significant reduction in nasal discharge compared with that of placebo treatment during the whole treatment period (p less than 0.001), but the drug was especially effective the first 3 days, when the watery secretion was predominant. It was concluded that this new spray can be of value in the first days of a cold, when nasal discharge is a nuisance.
On flocks influenced by closest neighbors (2016)

We prove, both for continuous time and discrete time, results establishing convergence to flocking in a model in which each agent is influenced by only a few closest neighbors. We show unconditional convergence to flocking when this number of closest neighbors is at least half of the population and, otherwise, conditional convergence. That is, convergence to flocking provided the initial positions and velocities satisfy an explicit constraint. We also show that the proportion of neighbors necessary for unconditional convergence, one-half, is sharp. Nothing less will do.
Effects of Long‐Term, Low‐Dose, Time‐Specified Melatonin Administration on Endocrine and Cardiovascular Variables in Adult Men (1990)

Six healthy adult male volunteers underwent serial blood drawings at 4-hour intervals over 24 hours for the definition of melatonin (MT), prolactin (PRL), cortisol, and testosterone circadian patterns. Serum levels of triiodotironine (T3) and thyroxine (T4) were determined at 0800. Systolic and diastolic blood pressure and heart rate were automatically recorded every 30 minutes for 24 hours. The responses of luteinizing hormone (LH), follicle stimulating hormone (FSH), PRL, thyroid stimulating hormone (TSH), cortisol, and aldosterone to a stimulation test with gonadotrophin-releasing hormone (Gn-RH), thyrotrophin-releasing hormone (TRH), adrenocorticotrophin (ACTH), and testosterone to human chorionic gonadotrophin (HCG) were also evaluated. The same protocol was repeated after a two-month course of treatment with MT, 2 mg per os daily at 1800. After treatment, we recorded a marked elevation of mean serum MT levels with a significant phase-advance of its circadian rhythm. The 24-hour patterns of cortisol and testosterone displayed an anticipation of the morning acrophase of about 1.5 hour (not significant) for cortisol and three hours (P less than 0.05) for testosterone. PRL pattern was unchanged as well as serum levels of thyroid hormones. The circadian organization of the cardiovascular variables did not show any changes after MT supplementation; the pituitary, adrenal, and testicular responses to specific stimuli were comparable before and after treatment. These results are compatible with the view that the MT signal may provide temporal cues to the neuroendocrine network for the organization of testicular circadian periodicity.
Preclinical models for obesity research (2016)

A multi-dimensional strategy to tackle the global obesity epidemic requires an in-depth understanding of the mechanisms that underlie this complex condition. Much of the current mechanistic knowledge has arisen from preclinical research performed mostly, but not exclusively, in laboratory mouse and rat strains. These experimental models mimic certain aspects of the human condition and its root causes, particularly the over-consumption of calories and unbalanced diets. As with human obesity, obesity in rodents is the result of complex gene-environment interactions. Here, we review the traditional monogenic models of obesity, their contemporary optogenetic and chemogenetic successors, and the use of dietary manipulations and meal-feeding regimes to recapitulate the complexity of human obesity. We critically appraise the strengths and weaknesses of these different models to explore the underlying mechanisms, including the neural circuits that drive behaviours such as appetite control. We also discuss the use of these models for testing and screening anti-obesity drugs, beneficial bio-actives, and nutritional strategies, with the goal of ultimately translating these findings for the treatment of human obesity.
Validation of the 7th TNM classification for non-small cell lung cancer: A retrospective analysis on prognostic implications for operated node-negative cases (2012)

The 7th TNM classification system is a more accurate predictor of prognosis in stage I operated patients than the old classification. The new system should be implemented even on retrospective cohorts especially when investigating the prognostic implication of the expression of molecular biomarkers.
Systemic Safety in Ranibizumab-Treated Patients with Neovascular Age-Related Macular Degeneration: A Patient-Level Pooled Analysis (2018)

The rates of cardiovascular and cerebrovascular events were low in these patients with nAMD and not clinically meaningfully different for patients treated with ranibizumab 0.5 mg versus sham or verteporfin, which supports the favorable benefit-risk profile of ranibizumab in the patient population with nAMD. Pooling these studies allows an analysis with higher power and precision compared with individual study analyses.
Geoacoustic scattering from the Pacific seafloor (1988)

It is amazing how much has been learned about the sediments and igneous crust beneath the sea by invoking the assumption of lateral homogeneity because almost every record obtained of sound propagating through the seafloor contains evidence of lateral heterogeneity and scattering. Three scales of scattering are evident: (1) There is the focusing and scattering of energy due to lateral heterogeneity within the seafloor. This causes anomalously high- or low-amplitude arrivals but no new arrivals; (2) there are diffractions from isolated topographic irregularities such as hills and valleys. In some cases, the hyperbolic appearance of these arrivals is evident on refraction sections; and (3) fine scale heterogeneity in the seafloor causes incoherency and time spread of arrivals. These are ubiquitous effects in seafloor reflections and refractions. These three phenomena will be demonstrated in observed data from the Pacific and in synthetic seismograms.
Patterns of elevation of plasma 2'-deoxyuridine, a surrogate marker of thymidylate synthase (TS) inhibition, after administration of two different schedules of 5-fluorouracil and the specific TS inhibitors raltitrexed (Tomudex) and ZD9331. (2002)

5-Fluorouracil (5-FU) exerts cytotoxic effects through inhibition of thymidylate synthase (TS) and incorporation of metabolites into RNA. TS inhibition may be greater for infusional 5-FU, with bolus regimens more likely to cause RNA effects. Elevation of plasma 2'-deoxyuridine (dUrd) is a surrogate marker of TS inhibition. Nineteen patients were treated with continuous infusion (CI) 5-FU 300mg/m(2)/day or bolus 5-FU 425mg/m(2)/day plus leucovorin (LV) 20mg/m(2)/day days 1-5. Pretreatment (day 1) and day 2, 3, 4, 5, 8, 15, 22, and 29 plasma samples were assayed for dUrd by reverse-phase high-performance liquid chromatography. In patients treated with bolus 5-FU/LV, dUrd elevation at 24 and 48 h was 235 +/- 125 and 254 +/- 119%, respectively, falling to 138 +/- 58%, 156 +/- 89%, and 92 +/- 25% on days 8, 15, and 22, respectively. dUrd elevation with CI 5-FU was 229 +/- 86% at 24 h and 239 +/- 86, 240 +/- 98%, and 255 +/- 109% at days 15, 22, and 29, respectively. Duration of dUrd elevation was generally less than 8 days for bolus 5-FU/LV. A single dose of raltitrexed (3 mg/m(2)) gave a similar profile to this regimen. ZD9331 (130 mg/m(2), days 1 and 8) gave dUrd elevation for 14 of 21 days, with some recovery prior to day 8. Thus, both 5-FU regimens inhibit TS, and prolonged TS inhibition is achieved by CI 5-FU without significant toxicity. This suggests that the mechanism of antiproliferative toxicity from bolus 5-FU/LV is partly non-TS mediated. These results clarify underlying pharmacodynamic processes and could guide scheduling of 5-FU and TS inhibitors.
Chapter 24: Chemical Resistance of Concrete (2006)

THIS CHAPTER BUILDS UPON CHAPTERS ON THE same topic from previous editions of the ASTM STP 169 series. Due to the fundamental nature of the subject, much of what appeared before in ASTM STP 169, 169A, and 169B, authored by Lewis H. Tuthill, and 169C, authored by G. W. DePuy, appears again here. This chapter will review and update the topic as addressed by the previous authors, introduce new technology that has been developed, and include updated references.
The outcome of cyberknife treatment for primary or metastatic malignant lung tumors (2014)

Background: To analyze the local control of malignant lung tumors and survival of nonsmall cell lung cancer (NSCLC) patients after stereotactic ablative radiotherapy with CyberKnife. Materials and Methods: Patients with malignant lung tumors treated by CyberKnife between July 2007 and October 2010 at our institute were retrospectively reviewed. A total of 55 patients with 110 malignant lung tumors were included. There were 32 men and 23 women, and the median age was 67 years. There were 11 early-stage NSCLCs, while the other 44 patients with 99 lesions were metastatic lung tumors. The median gross tumor volume was 13.3 ml. Radiotherapy schedules include 40-60 Gy in 4-5 fractions, 45-60 Gy in 3 fractions and 30 Gy in 1 fraction. Results: The median follow-up time for patients alive was 34 months. The local control rates for all tumors were 96% at 1-year and 80% at 2 years. Univariate analysis demonstrated that target volume was important for local control. Biologically equivalent dose (BED) ≥100 Gy provided significantly higher chance to achieve a complete response than BED <100 Gy. The disease-specific survival rates for early-stage NSCLC were 80% at 1-year and 60% at 2 years. Treatment related complications were acceptable. No grade 2-5 adverse events were noted. Conclusions: CyberKnife can be used for NSCLC and metastatic lung tumors, either peripheral or central location, with good local control and acceptable side-effects.
ESTUDIO DE LA TERCERA LAY DE NEWTON A TRAVÉS DE EXPERIMENTOS SENCILLOS, DE BAJO COSTE ECONÓMICO Y GRAN VALOR PEDAGÓGICO (2016)

Este trabajo tiene como propósito enfatizar en la optimización del proceso de aprendizaje cualesquiera que sean las condiciones que se nos presenten, para ello se enfatiza en la importancia metodológica de la tercera ley de Newton, que suele quedar relegada a segundos o terceros planos. Se muestra un sistema de experiencias de fácil desarrollo, realizables con recursos económicos al alcance de todos y de alto impacto motivacional en los estudiantes. Con este sistema de experimentos significativos, se analizan sus valores científico-metodológicos, sus interrelaciones con la resolución de cuestiones, problemas, preguntas, actividades extraescolares y la evaluación. Además, por una parte se estimula la activación de la actuación cognoscitiva de los estudiantes, exquisitamente concebida y dirigida por el profesor; y por otra, se enfatiza en la sistematización como una solución metodológica para contribuir a desarrollar la formación de la concepción científica del mundo de los estudiantes.
First-order-hold sampling of positive real systems and subspace identification of positive real models (2004)

This work shows that the transfer function of a continuous-time positive real system with first-order-hold sampling is discrete-time positive real. Next, a method for identifying models that are constrained to be discrete-time positive real is developed.
Prevalence of chronic fatigue syndrome in metropolitan, urban, and rural Georgia (2007)

We estimated that 2.54% of the Georgia population suffers from CFS, which is 6- to 10-fold higher than previous population-based estimates in other geographic areas. These differences may reflect broader screening criteria and differences in the application of the case definition. However, we cannot exclude the possibility that CFS prevalence may be higher in Georgia than other areas where it has been measured. Although the study did not identify differences in overall prevalence between metropolitan, urban, and rural Georgia populations, it did suggest the need for additional stratified analyses by geographic strata.
Design and study of meshed and optically transparent dipole antennas at 2.45 GHz (2019)

International audience
A New Simple Power-Factor-Based Vector Control Method for Sensorless Drive of Permanent-Magnet Synchronous Motors (2007)

This paper proposes a new simple vector control method for sensorless drive of permanent-magnet synchronous motors (PMSMs). The proposed method takes an approach to estimate directly phase of the quasi-optimal stator current through control of the power factor phase instead of estimation of rotor phase. It is established based on new analysis of motor characteristics and has the following attractive features: 1) it can be applied to both of salient and non-salient pole PMSMs; 2) stator current control quasi-minimizing copper and/or iron loss is directly performed; 3) it is insensitive to motor parameter variation, and does not requires motor parameters with precision; 4) it is simple. Simple and practical rules for selecting design parameters of the method are clearly given based on the analysis. Effectiveness of the analysis and usefulness of the proposed method are verified through experiments.
Channel Equalization and Phase Noise Suppression For OFDM Systems in a Time-Varying Frequency Selective Channel Using Particle Filtering (2006)

In this paper we address the problem of channel equalization and phase noise suppression in orthogonal frequency division multiplexing (OFDM) systems. For OFDM systems, random phase noise introduced by the local oscillator causes two effects: the common phase error (CPE), and the intercarrier interference (ICI). The performance of coherent OFDM systems greatly depends on the ability to accurately estimate the effective dynamic channel, i.e. the combined effect of the CPE and the time-varying frequency selective channel. The proposed approach uses a pilot tone aided particle filter to track/estimate the effective dynamic channel in the time domain and equalizes in the frequency domain. The particle filter is efficiently implemented by combining sequential importance sampling, principles of Rao-Blackwellization, and strategies stemming from the auxiliary particle filter. Simulation results are provided to illustrate the effectiveness of the proposed algorithm.
Quantitative detection of myocardial ischaemia by stress echocardiography; a comparison with SPECT (2009)

In this agreement study with SPECT, RTP-ASE Qontrast quantification of myocardial ischaemia was less accurate and less feasible than visual evaluation and needs further development to be clinically useful.
Transient control levels philosophy and implementation Part 1: The Reasoning behind the philosophy (1977)

This i s the f i r s t o f a p a i r o f papers descr ibing how be t te r t rans ient protect ion might be achieved through the use o f a Transient Cont r o l Level (TCL) philosophy. The authors have developed and are proposing t h i s TCL philosophy because damage t o and upset o f e lect ron ic and other low-voltage equipment by t rans ients seems t o be a never-ending problem, and one t ha t i s l i k e l y t o get worse i n the fu tu re as e lect ron ic cont ro ls permeate even more o f the products which a f f e c t our l i ves . A number o f proposals have been made some already incorporated i n t o standards on various t es t wave shapes and speci f i cations. The authors propose an approach in te g ra t ing many o f these proposals whi le focusing a t ten t ion on s i gn i f i can t parameters.
How Old Do You Look? Inferring Your Age From Your Gaze (2018)

International audience
Mediators of Inflammation (2022)

Mediators of Inflammation publishes papers on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules
2-Nitropyrrole cross-coupling enables a second generation synthesis of the heronapyrrole antibiotic natural product family (2016)

The heronapyrroles are a family of antibiotic natural products containing the rare 2-nitropyrrole motif. We report here a second generation total synthesis that circumvents problems of selective pyrrole nitration and alkene formation that limited the utility of previous approaches. Stille sp<sup>3</sup>-sp<sup>2</sup> cross coupling of a novel 2-nitropyrrole fragment was developed to install the key C7,8 olefin with complete regiochemical control. An unusual Hunsdiecker-type decarboxylative halogenation was also identified, providing access to the complex vinyl stannane coupling partners required for formation of the natural product.
Removal of natural organic matter using UVC/TiO2 photocatalysisprocess coupled with coagulation treatment (2011)

The use of standalone titanium dioxide (TiO2) photocatalytic treatment and one that is combined with coagulation process to treat natural organic matter (NOM) from two different water sources (synthetic water containing 10 ppm of humic acid and water samples sourced from Myponga reservoir) is investigated herein. In the combined process, the water samples were treated with a novel composite coagulant prepared from polyaluminium chloride and chitosan, after which the water was filtered and transferred to the photoreactor for further photocatalytic treatment. The water samples were analysed for changes in UV254 Absorbance, Dissolved Organic Carbon (DOC) concentration and trihalomethane formation potential (THMFP). Results showed that chitosan reduced the dose of aluminium required, and TiO2 photocatalytic treatment process coupled with coagulation treatment was able to reduce the duration needed for the photocatalytic removal of natural organic matter while maintaining similar high removal efficiency as standalone TiO2 photocatalysis treatment (>90%). The THMFP was shown to be reduced to low ppb levels (<50 ppb).
Repolarization changes following left bundle branch area pacing versus conventional biventricular pacing in patients with dyssynchronous heart failure (2023)

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Dutch Heart Foundation. Background Biventricular pacing (BiVP) is the standard treatment for patients with dyssynchronous heart failure. Despite the effectiveness of BiVP, 6% of patients develop ventricular tachyarrhythmia’s (VTAs) within one year following implantation. The relationship between BiVP and the development of VTAs is still under debate. The left-sided epicardium-to-endocardium activation during BiVP creates a nonphysiological activation and repolarization and might provoke VTAs. A relatively new treatment option is left bundle branch area pacing (LBBAP), in which the physiological activation of the left ventricle is restored. We hypothesize that LBBAP leads to a more homogenous repolarization compared to conventional BiVP. Purpose To compare time-dependent repolarization changes in patients with dyssynchronous heart failure receiving LBBAP versus BiVP. Methods Patients with dyssynchronous heart failure eligible for cardiac resynchronization therapy who underwent LBBAP (n=13) or BiVP (n=28) were retrospectively included. Standard 12-lead electrocardiograms (ECG) obtained prior to implantation [baseline], shortly following implantation (0-2 days,[acute]) and during follow-up (31-180 days, [FU]) were analyzed. The QT interval and Tpeak to Tend interval (Tpeak-Tend) were calculated using a semi-automatic approach in MATLAB. Repolarization differences between LBBAP and BiVP patients were determined using the Mann-Whitney U-test. Time-dependent changes within groups were determined using the Wilcoxon signed rank tests. Significance was defined as a p-value ≤0.05. Results The QT interval did not significantly change over time in BiVP patients, but it decreased immediately following implantation and during FU in LBBAP patients. At FU, QT interval was significantly lower in LBBAP than in BiVP patients (Figure 1, left panel). A slight increase in Tpeak-Tend interval over time in BiVP patients, while it tends to decrease over time in LBBAP patients can be seen in the right panel. Acutely and long term after implantation, Tpeak-Tend was significantly lower in LBBAP than in BiVP patients. Conclusion LBBAP is associated with lower QT and Tpeak-Tend intervals compared to BiVP during FU, suggesting that LBBAP leads to less heterogeneity of repolarization over time. These findings suggest a more physiological repolarization pattern in LBBAP compared to BiVP, which may decrease the risk of developing VTAs.
M2 Macrophages Promote Collagen Expression and Synthesis in Laryngotracheal Stenosis Fibroblasts (2020)

NA Laryngoscope, 131:E346-E353, 2021.