gebhart/patrepeval huggingface dataset:
Reminiscing in depressed, ageing patients: Effect of ECT and antidepressants (1990)

Abstract Reminiscing, the mental activity of dwelling on the past, was quantified during a semistructured interview known for its reliability. Eighteen depressed, hospitalized patients (mean age 62 years; DSM‐III major depressive disorder) were compared to 12 normals with equivalent demographic characteristics. The depressed patients prior to treatment had significantly lower reminiscing scores. When the interviews were repeated after 3–4 weeks, the 10 patients treated with ECT were significantly improved clinically and their reminiscing score had increased to normal levels. The eight patients who received antidepressant medication were non‐responsive to treatment and reminiscing was further reduced during their second interview. The role of reminiscing and its therapeutic potential in ageing are discussed.
Impurity Band Conduction in a High Temperature Ferromagnetic Semiconductor (2006)

The band structure of a prototypical dilute magnetic semiconductor (DMS), Ga1-xMnxAs, is studied across the phase diagram via infrared and optical spectroscopy. We prove that the Fermi energy (EF) resides in a Mn-induced impurity band (IB). Specifically the changes in the frequency dependent optical conductivity [sigma1(omega)] with carrier density are only consistent with EF lying in an IB. Furthermore, the large effective mass (m*) of the carriers inferred from our analysis of sigma1(omega) supports this conclusion. Our findings demonstrate that the metal to insulator transition in this DMS is qualitatively different from other III-V semiconductors doped with nonmagnetic impurities. We also provide insights into the anomalous transport properties of Ga1-xMnxAs.
Estimation of Vital Signs from Ambient-Light Non-Contact Photoplethysmography (2013)

Abstract In this thesis we have investigated different aspects of non-contact photoplethysmography (PPG) using only ambient lighting. We have investigated how to develop a functional, automatic system based on this to detect heart rate. We have also investigated how to use the concept of non-contact PPG to acquire further relevant medical information from a human subject. Abstract We have investigated different color spaces and found that the Hue and Saturation channels from HSL and HSV color spaces are far superior to the Green channel of the RGB color space, which has previously been used. Especially under circumstances with much noise, are these channels superior and more robust against noise. Abstract The concept of independent component analysis (ICA) has been investigated as a method of improving results. It is found to improve some channels and color spaces, but the best ICA channel does not have better performance than the best non-ICA channel. Abstract The phase of, and difference between, PPG signals has been investigated as a means of acquiring medical information. The phase measurements are highly vulnerable to noise, but there are indications that occlusion can induce a phase difference between different limbs. This difference can be used to calculate change in blood pressure. Abstract We have synchronized ECG and PPG data, and found that there is a high correlation between the two. Pulse transit time (PTT) from the heart to the measurement site can be calculated using this synchronized information. Abstract Further have different motion compensation algorithms and signal processing techniques been investigated with the goal of improving the PPG signal and a programs ability to automatically detect heart rate.
Substrate hot-electron injection EPROM (1984)

A new EPROM approach using substrate hot-electron injection is introduced. Electron injection into the substrate is achieved, using positive voltages only, to facilitate the integration of the technique into a memory array. High-injection efficiency of electrons to the floating gate is achieved, enabling 5-V only operation, where the high voltages are generated on chip. Programming speed of 1-V/ms for total collection of 10 µA per bit line is realized. The main disadvantages of this EPROM approach are circuit complexity and cell size.
Anti-inflammatory effects of an inflammatory chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21-triggered integrin-mediated adhesions (2008)

Our studies focus on the pathways that restrict homing of specific subsets of immune cells, and thereby fine-tune the immune response at specific lymphoid and peripheral tissues. Here, we report that CCL2 (at picomolar [pM] levels) renders both murine and human T cells defective in their ability to develop CCR7-triggered activation of LFA-1- and LFA-1-mediated adhesion strengthening to endothelial ICAM-1 both in vitro and in vivo. CCL2 also attenuated lymphocyte chemotaxis toward lymph node chemokines. Consequently, low-dose CCL2 inhibited lymphocyte homing to peripheral lymph nodes but did not affect lymphocyte trafficking through the spleen. Impaired homing of lymphocytes to peripheral lymph nodes resulted in attenuated progression of both asthma and adjuvant arthritis. Thus, pM levels of circulating CCL2 can exert global suppressive effects on T-cell trafficking and differentiation within peripheral lymph nodes, and may be clinically beneficial as an anti-inflammatory agent.
Role of Cyclin D3 in the Biology of Herpes Simplex Virus 1 ICP0 (2001)

Earlier reports from this laboratory have shown that the promiscuous transactivator infected-cell protein 0 (ICP0) binds and stabilizes cyclin D3, that the binding site maps to aspartic acid 199 (D199), and that replacement of D199 with alanine abolishes binding and reduces the capacity of the mutant virus to replicate in quiescent cells or to cause mortality in mice infected by a peripheral site. The objective of this report was to investigate the role of cyclin D3 in the biology of ICP0. We report the following results. (i) Wild-type ICP0 activates cyclin D-dependent kinase 4 (cdk4) and stabilizes cyclin D1 although ICP0 does not interact with this cyclin. (ii) The D199A mutant virus (R7914) does not activate cdk4 or stabilize cyclin D1, and neither the wild-type nor the mutant virus activates cdk2. (iii) Early in infection of human embryonic lung (HEL) fibroblasts both wild-type and D199A mutant ICP0s colocalize with PML, and in these cells the ND10 nuclear structures are dispersed. Whereas wild-type ICP0 is transported to the cytoplasm between 3 and 9 h. after infection, ICPO containing the D199A substitution remains quantitatively in the nucleus. (iv) To examine the interaction of ICP0 with cyclin D3, we used a previously described mutant carrying a wild-type ICP0 but expressing cyclin D3 (R7801) and in addition constructed a virus (R7916) that was identical except that it carried the D199A-substituted ICP0. Early in infection with R7801, ICP0 colocalized with cyclin D3 in structures similar to those containing PML. At 3 h after infection, ICP0 was translocated to the cytoplasm whereas cyclin D3 remained in the nucleus. The translocation of ICP0 to the cytoplasm was accelerated in cells expressing cyclin D3 compared with that of ICP0 expressed by wild-type virus. In contrast, ICP0 carrying the D199A substitution remained in the nucleus and did not colocalize with cyclin D3. These studies suggest the following conclusions. (i) ICP0 brings to the vicinity of ND10 cyclin D3 and, in consequence, an activated cdk4. The metabolic events occurring at or near that structure and involving cyclin D3 cause the translocation of ICP0 to the cytoplasm. (ii) In the absence of the cyclin D3 binding site in ICP0, cyclin D3 is not brought to ND10, cyclin D is not stabilized, and the function responsible for the translocation of ICP0 is not expressed, and in quiescent HEL fibroblasts the yields of virus are reduced.
Peri‐operative chemotherapy for resectable colorectal liver metastasis: Does timing of systemic therapy matter? (2011)

Pre-operative chemotherapy was associated with a trend toward increased morbidity among patients undergoing a major hepatic resection. Receipt of pre-operative chemotherapy was associated with neither an advantage nor disadvantage in terms of long-term survival.
Small Molecule Drugs That Inhibit Phagocytosis (2023)

In our initial publication on the in vitro testing of more than 200 compounds, we demonstrated that small molecules can inhibit phagocytosis. We therefore theorized that a small molecule drug discovery-based approach to the treatment of immune cytopenias (ITP, AIHA, HTR, DHTR) is feasible. Those earlier studies showed that small molecules with anti-phagocytic groups, such as the pyrazole core, are good models for producing efficacious phagocytosis inhibitors with low toxicity. We recently screened a chemical library of 80 compounds containing pyrazole/isoxazole/pyrrole core structures and found four hit molecules for further follow-up, all having the pyrazole core structure. Subsequent evaluation via MTT viability, LDH release, and apoptosis, led to the selection of two lead compounds with negligible toxicity and high efficacy. In an in vitro assay for inhibition of phagocytosis, their IC<sub>50</sub> values were 2-4 µM. The rational development of these discoveries from hit to lead molecule stage, viz. independent synthesis/scale up of hit molecules, and in vivo activities in mouse models of autoimmune disease, will result in the selection of a lead compound(s) for further pre-clinical evaluation.
15.6 A 30-to-80MHz simultaneous dual-mode heterodyne oscillator targeting NEMS array gravimetric sensing applications with a 300zg mass resolution (2017)

The extreme sensitivity of nano electro mechanical system (NEMS) to atomic scale physical variations has led to the breakthrough development of NEMS-based mass spectrometry systems capable of measuring a single molecule [1]. Parallel sensing using thousands of devices will help to circumvent the small effective sensing area while opening new perspectives for applications that require spatial mapping. While the development of NEMS CMOS co-integration technology [2] is of paramount importance to achieve high density sensor arrays (>1000 devices), the readout circuitry capable of tracking NEMS resonator frequency shifts is still the limiting factor for the very large scale integration of individually addressed sensors. Moreover, in order to resolve the mass and position of an adsorbed analyte, single particle mass sensing applications require to track simultaneously and in real time at least two modes of the resonators. This requirement adds complexity to the design of the overall system. To respond to the size, power consumption and resolution constraints linked to NEMS array measurement, we propose a compact heterodyne self-oscillator analog front-end IC which performs 1ms simultaneous dual-mode frequency tracking compatible with a “pixel-based” readout scheme. We report less than 1mA power consumption with a 300zg mass resolution for 26000μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> size.
Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site (1992)

We have synthesized a series of benzazepinones (2) in order to determine the structure-activity relationships (SAR) for calcium channel blockers related to diltiazem. A prerequisite for calcium channel blocking activity in vitro and in vivo is the presence of two pharmacophores: a 4'-aryl methyl ether and a basic substituent appended to N1 with a pKa in the physiological range. When these constraints are satisfied, a wide variety of substitution is tolerated at C6, C7, and C3. The presence of an electron-withdrawing group at C6 appears to enhance potency in vitro and in vivo. For such benzazepinones, activity is primarily dependent upon lipophilicity, as measured by log P. We believe these compounds must partition into the cell membrane in order to access their receptor. The quaternary methiodide 15k was used to demonstrate that the binding site for benzazepinones is on the intracellular face of the membrane. This work represents the first comprehensive SAR of diltiazem-like calcium channel blockers.
Phrase-Based Translation Model for Question Retrieval in Community Question Answer Archives (2011)

Community-based question answer (Q&amp;amp;A) has become an important issue due to the popularity of Q&amp;amp;A archives on the web. This paper is concerned with the problem of question retrieval. Question retrieval in Q&amp;amp;A archives aims to find historical questions that are semantically equivalent or relevant to the queried questions. In this paper, we propose a novel phrase-based translation model for question retrieval. Compared to the traditional word-based translation models, the phrasebased translation model is more effective because it captures contextual information in modeling the translation of phrases as a whole, rather than translating single words in isolation. Experiments conducted on real Q&amp;amp;A data demonstrate that our proposed phrasebased translation model significantly outperforms the state-of-the-art word-based translation model. 1
97-02: Heart rate variability features derived from ECG recordings may establish specific “signatures” of different causes of TLOC (2016)

Introduction: Transient loss of consciousness (TLOC) can be due to syncope, epilepsy or psychogenic causes. ECG monitoring allows symptom/ECG correlation. Analysis of cardiac features derived from ECG may define “signatures”, which could be used for distinction between different causes of TLOC. Methods: At the Epilepsy Monitoring Unit (EMU), 43 patients underwent videotelemetry with continuous EEG and ECG (27 epileptic and 16 psychogenic). In the Syncope Clinic, 20 patients had tilt-induced syncope. RR intervals during symptoms were extracted. A marginality index (MI), reflecting cardiac hyperexcitability, was computed as the % of RR values outside a confidence interval (over 40 consecutive beats). Heart rate variability (HRV) was analyzed using a parametric spectral estimation with sliding window of 60–240s shifted in 5–20s increments. Sympatho-vagal balance was computed from HRV as the ratio of low frequency (LF:0.04-0.15Hz) to high frequency components (HF:0.15-0.4Hz). Results: 92% of epileptic fits showed MI >20% while 56% of psychogenic episodes had MI < 10% and 100% of reflex syncope had MI < 5%. Patterns resulting from HRV alone were less discriminant.
Reviewer #2 (Public Review): Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population (2023)

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environment interactions underlying inflammation and IBD. Here, we profiled the colon transcriptome of 52 BXD mouse strains fed with a chow or high-fat diet (HFD) and identified a subset of BXD strains that exhibit an IBD-like transcriptome signature on HFD, indicating that an interplay of genetics and diet can significantly affect intestinal inflammation. Using gene co-expression analyses, we identified modules that are enriched for IBD-dysregulated genes and found that these IBD-related modules share cis-regulatory elements that are responsive to the STAT2, SMAD3, and REL transcription factors. We used module quantitative trait locus (ModQTL) analyses to identify genetic loci associated with the expression of these modules. Through a prioritization scheme involving systems genetics in the mouse and integration with external human datasets, we identified Muc4 and Epha6 as the top candidates mediating differences in HFD-driven intestinal inflammation. This work provides insights into the contribution of genetics and diet to IBD risk and identifies two candidate genes, MUC4 and EPHA6, that may mediate IBD susceptibility in humans.
Fixed combinations in the management of hypertension: patient perspectives and rationale for development and utility of the olmesartan &ndash; amlodipine combination (2008)

Although the awareness and control of hypertension has increased, only 37% of hypertensive patients in the US achieve the conservative goal of <140/90 mmHg. Achieving optimal blood pressure (BP) control is the most important single issue in the management of hypertension, and in most hypertensive patients, it is difficult or impossible to control BP with one drug. Blocking two or more BP regulatory systems provides a more effective and more physiologic reduction in BP, and current guidelines have recommended the use of combination therapy as first-line treatment, or early in the management of hypertension. Fixed combination therapy is an efficacious, relatively safe, and may be cost-effective method of decreasing BP in most patients with essential hypertension. Similar to other combinations, fixed-dose combination tablets containing the dihydropyridine calcium channel blocker amlodipine and the angiotensin II receptor blocker olmesartan bring together two distinct and complementary mechanisms of action, resulting in improved BP control and potential for improved target organ protection relative to either class of agent alone.
Imaging of the islet neural network (2014)

The islets of Langerhans receive signals from the circulation and nerves to modulate hormone secretion in response to physiological cues. Although the rich islet innervation has been documented in the literature dating as far back as Paul Langerhans' discovery of islets in the pancreas, it remains a challenging task for researchers to acquire detailed islet innervation patterns in health and disease due to the dispersed nature of the islet neurovascular network. In this article, we discuss the recent development of 3-dimensional (3D) islet neurohistology, in which transparent pancreatic specimens were prepared by optical clearing to visualize the islet microstructure, vasculature and innervation with deep-tissue microscopy. Mouse islets were used as an example to illustrate how to apply this 3D imaging approach to characterize (i) the islet parasympathetic innervation, (ii) the islet sympathetic innervation and its reinnervation after transplantation under the kidney capsule and (iii) the reactive cellular response of the Schwann cell network in islet injury. While presenting and characterizing the innervation patterns, we also discuss how to apply the signals derived from transmitted light microscopy, vessel painting and immunostaining of neural markers to verify the location and source of tissue information. In summary, the systematic development of tissue labelling, clearing and imaging methods to reveal the islet neuroanatomy offers insights to help study the neural-islet regulatory mechanisms and the role of neural tissue remodelling in the development of diabetes.
Methylchlorphosphane und Folgeprodukte (1973)

Abstract Methyldichlorphosphan und Dimethylchlorphosphan sind nur recht schwierig zu erhalten. Die Leichtigkeit, mit der aus ihnen zahlreiche Folgeprodukte hergestellt werden können, ist ein Zeichen für die hohe Reaktivität dieser Organohalogenphosphane. Anwendungsmöglichkeiten solcher Organophosphor‐Verbindungen liegen u.a. auf dem Gebiet des Pflanzenschutzes, des Korrosionsschutzes und des Flammschutzes sowie der Katalyse von Gasphasenreaktionen, z. B. der Entschwefelung von Gasgemischen.
Homomorphic Encryption for Security of Cloud Data (2016)

Cloud computing is a broad and diverse phenomenon. Users are allowed to store large amount of data on cloud storage for future use. The various security issues related to data security, privacy, confidentiality, integrity and authentication needs to be addressed. Most of the cloud service provider stores the data in plaintext format and user need to use their own encryption algorithm to secure their data if required. The data needs to be decrypted whenever it is to be processed. This paper focuses on storing data on the cloud in the encrypted format using fully homomorphic encryption. The data is stored in DynamoDB of Amazon Web Service (AWS) public cloud. User's computation is performed on encrypted data in public cloud. When results are required they can be downloaded on client machine. In this scenario users data is never stored in plaintext on public cloud.
Enhanced Procedure for Fabrication of an Ultrahydrophobic Aluminum Alloy Surface using Fatty Acid Modifiers (2017)

A superhydrophobic aluminum surface was fabricated through an enhanced low-cost approach and the effects of several relevant factors on static contact angle and sliding angle were investigated. First, the operating parameters including the etching time as well as the reaction time and temperature were varied. Next, the so-called chemical factors including three different fatty acids and five different solvents were examined. The surface was analyzed by means of SEM, ATR-FTIR, EDX, and WCA measurements. The results show that the immersion time of about 5 min and the reaction temperature of about 60 °C were the optimum conditions for the creation of a superhydrophobic Al surface with excellent self-cleaning properties. Overall, the choice of oleic acid and ethanol were found to be the best as the fatty acid and solvent, respectively. The highest contact angle was 163.7° and the lowest sliding angle was about 1°.
Different psychopathological models and quantified EEG in schizophrenia (1999)

This study lends support to the factor analysis of psychopathology, and specifically the tripartite syndrome model of schizophrenia, as a step in explicating the biological dimensions of the disorder.
Sparse Representation in Fourier and Local Bases Using ProSparse: A Probabilistic Analysis (2017)

Finding the sparse representation of a signal in an overcomplete dictionary has attracted a lot of attention over the past years. This paper studies ProSparse, a new polynomial complexity algorithm that solves the sparse representation problem when the underlying dictionary is the union of a Vandermonde matrix and a banded matrix. Unlike our previous work, which establishes deterministic (worst-case) sparsity bounds for ProSparse to succeed, this paper presents a probabilistic average-case analysis of the algorithm. Based on a generating-function approach, closed-form expressions for the exact success probabilities of ProSparse are given. The success probabilities are also analyzed in the high-dimensional regime. This asymptotic analysis characterizes a sharp phase transition phenomenon regarding the performance of the algorithm.
Baroreflex function in endurance- and static exercise-trained men (1988)

The effect of exercise training mode on reflex cardiovascular control was studied in a cross-sectional design. We examined the cardiovascular responses to progressive incremental phenylephrine (PE) infusion to maximal rates of 120 micrograms/min and the delta heart rate/delta blood pressure responses to lower body negative pressure (LBNP) to -50 Torr in 30 men who were either endurance exercise trained (ET), untrained (UT), or weight trained (WT). During PE infusion, measures of blood pressures, forearm blood flow, heart rate and cardiac output, and calculations of forearm vascular resistance, stroke volume, and peripheral vascular resistance were made at each infusion rate when steady-state blood pressure was attained. No significant differences (P less than 0.05) in forearm blood flow or resistance were observed between the groups at any dose of PE, suggesting that the vasoconstrictor response was similar among the groups. Regression analyses of heart rate against mean blood pressure during the PE infusion were performed to evaluate baroreflex function. A linear model was used and correlation coefficients ranging from 0.82 to 0.96 were obtained (P less than 0.05). The slope of the line of best fit for the ET subjects (-0.57) was significantly less (P less than 0.05) than the slopes obtained for either the UT (-0.91) or WT (-0.88) subjects. In addition, the delta heart rate/delta blood pressure measurements obtained during LBNP reflected a similarly significant attenuation of reflex chronotropic control in the ET subjects.(ABSTRACT TRUNCATED AT 250 WORDS)