gebhart/patrepeval huggingface dataset:
Lightweight, Flexible, High-Efficiency III-V Multijunction Cells (2006)

Large-area (26.6 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ), thin GaInP/GaInAs/Ge triple-junction (TJ) solar cells with thickness as low as 50 mum were demonstrated. The average conversion efficiency of fifty thin TJ cells is 28 %, 1-sun AMO. The thin TJ cells showed nominal performance after welding of interconnects and flexibility test (50 mm curvature radius). Prototype coupons made with these thin TJ cells met flexible solar module bending requirement of 100 mm radius. The thin-cell coupons showed a specific power of 500 W/kg and a power density of 325 W/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2 </sup> . Ultra-thin (<10 mum thick) GaInP/Ga(In)As dual-junction (DJ) cells with size ranges from 0.5 to 26.6 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> were fabricated using 4" Ge or GaAs wafers. Preliminary test data of the ultra-thin DJ cells showed a specific power of 2067 W/kg and a power density of 283 W/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The ultra-thin solar cells continued to demonstrate nominal performance after handling and flexing to a radius of 12 mm. Our results suggested that both the thin cell and the ultra-thin cell technologies can be incorporated with current and future solar cell designs
Study of protein modification by 4-hydroxy-2-nonenal and other short chain aldehydes analyzed by electrospray ionization tandem mass spectrometry (2003)

A convenient way to study lipid oxidation products-modified proteins by means of suitable model systems has been investigated. As a model peptide, the oxidized B chain of insulin has been chemically modified by either 4-hydroxy-2-nonenal (HNE) or hexanal and the extent, sites, and structure of modifications were assessed by electrospray mass spectrometry. A reduction step, using either NaCNBH(3) or NaBH(4), was also studied to stabilize the alkylated compounds. From the data gathered, it appeared that NaCNBH(3), when added at the beginning of incubation, dramatically influenced the HNE-induced modifications in terms of the addition mechanism (Schiff base formation instead of Michael addition) but also of the amino acid residues modified (N-terminal amino acid instead of histidine residues). However, by reducing the HNE-adducted species at the end of the reaction with NaBH(4), the fragment ions obtained in the product ion scan experiments become more stable and thus, easier to interpret in terms of origin and mechanism involved. With regard to hexanal induced modifications, we have observed that hexanal addition under reductive conditions led to an extensive modification of the peptide backbone. Moreover, as confirmed by "in-source" collision followed by collision induced dissociation (CID) experiments on selected precursor ions (pseudo-MS(3) experiments), N,N-di-alkylations were first observed on the N-terminal residue and further on Lys(29) residue. On the other hand, compared to the native peptide, no significant changes in MS/MS fragmentation patterns (b and y ions series) were observed whatever the basic site modified by the aldehyde-addition.
Effects of Toxoplasma gondii infection on cognition, symptoms, and response to digital cognitive training in schizophrenia (2022)

Studies indicate that neuroscience-informed digital cognitive training can remediate cognitive impairments in schizophrenia, but the factors contributing to these deficits and response to treatment remain unclear. Toxoplasma gondii is a neuroinvasive parasite linked to cognitive decline that also presents a higher prevalence in schizophrenia. Here, we compared the cognition and symptom severity of IgG seropositive (TOXO+; n = 25) and seronegative (TOXO-; n = 35) patients who participated in a randomized controlled trial of digital cognitive training. At baseline, TOXO+ subjects presented lower global cognition than TOXO- (F = 3.78, p = 0.05). Specifically, TOXO+ subjects showed worse verbal memory and learning (F = 4.48, p = 0.03), social cognition (F = 5.71, p = 0.02), and higher antibody concentrations were associated with increased negative (r = 0.42, p = 0.04) and total (r = 0.40, p = 0.04) schizophrenia symptoms. After training, the TOXO+ group showed higher adherence to the intervention (X<sup>2</sup> = 9.31, p = 0.03), but there were no differences in changes in cognition and symptoms between groups. These findings highlight the association between seropositivity to T. gondii and deteriorated cognition and symptoms in schizophrenia. Further research is needed to assess the specific efficacy of digital cognitive training on this population.
A new family of irregular LDPC Codes (2004)

In this paper, we present a method for constructing irregular LDPC (low density parity check) codes based on the optical orthogonal codes. The resulting codes are quasi-cyclic codes and can be encoded with low complexity. They perform well with the sum-product iterative decoding.
The Subjective Duration of Time in the Experience of Urban Places (2001)

In a pair of field experiments a relationship between the physical space of streets and individual perceptions of the passing of time was discovered. Within the context of a larger study of the pedestrian experience of urban places, 42 individuals were asked to estimate the duration of time required to walk path segments through different spatial configurations. The results showed statistically significant differences between the estimates for the different paths, consistent across the two experiments and apparently related to spatial attributes of the streets through which the paths passed. From these experiments one can conclude that there is a connection between the designed, physical place and subjective sense of time. The multi-variate nature of the field work makes it impossible to demonstrate specific causal relationships. However, the consistency between the two experiments - following upon previous research - does point to plausible speculations. The implications of these findings for the experience of urban places and urban design interventions are also speculative, requiring further research.
Magnetically Navigated Intracellular Delivery of Extracellular Vesicles Using Amphiphilic Nanogels (2019)

Various cells in vivo secrete exosomes consisting of lipid bilayers. They carry mRNAs and miRNAs capable of controlling cellular functions and can be used as drug delivery system nanocarriers. There is the current need to further improve the efficiency of exosome uptake into target cells. In this study, we prepared a hybrid of exosomes and magnetic nanoparticles, which could be guided to target cells by a magnetic field for efficient uptake. Magnetic nanogels were prepared and hybridized to fluorescently labeled exosomes isolated from PC12 cells. By applying a magnetic field to a hybrid with magnetic nanogel, exosomes were efficiently transferred into target cells as confirmed by confocal laser microscopy. Finally, we found that differentiation of adipose-derived stem cells to neuron-like cells was enhanced by magnetic induction of the exosome-magnetic nanogel hybrid, indicating maintenance of the intrinsic functions of the exosomes in the differentiation of adipose-derived stem cells.
Polyautoimmunity in Patients with LPS-Responsive Beige-Like Anchor (LRBA) Deficiency (2018)

Mutation in LRBA gene is one of the causes of monogenic polyautoimmunity. Awareness of this association is important in order to make an early diagnosis and prompt treatment.
Research on Texture Defect Detection Based on Faster-RCNN and Feature Fusion (2019)

Product texture defect detection is one of the important quality inspection procedures in industrial production. For the traditional defect detection methods, the detection processes are cumbersome, the accuracies are not high, and the generalizations are not strong. This paper proposes a method based on Faster-RCNN and feature fusion. This method uses the ResNet network model to extract the shared convolution feature, and combines the high-level features of the ROI pooling layer output with the low-level features obtained by the direction gradient histogram (HOG) as full connection layer input. Then, optimizing the model by adjusting the training parameters and convolutional neural network structure. Experiments on the German Pattern Recognition Association (GAPR) texture defect dataset show that the proposed model has improved in the mAP index. Through the migration learning strategy, experiments are carried out on several sets of actually collected data sets. The experimental results show that the model has good adaptability and can be applied to the surface defect detection of workpieces under different conditions.
Special Issue on Earthquake Engineering for Transportation Structures (2005)

This second Special Issue is dedicated to Earthquake Engineering for Transportation Structures. These special issues provide a forum for researchers and practicing professionals to present their work in a publication of related papers on one subject.
Associating quantitative behavioral traits with gene expression in the brain: searching for diamonds in the hay (2007)

Supplementary data are available at Bioinformatics online.
An intelligent vertical handoff algorithm in heterogeneous wireless networks (2008)

To coordinate the various access technologies in the 4G-communication system, intelligent vertical handoff algorithms are required. This paper mainly deals with a novel vertical handoff decision algorithm based on fuzzy logic with the aid of grey theory and dynamic weights adaptation. The grey prediction algorithm (GPA) takes 4 sampled received signal strengths as input parameters, and calculates the predictive received signal strength in order to reduce the call dropping probability. The fuzzy logic theory based Quantitative Decision Algorithm takes 3 QoS metrics, received signal strength (RSS), available bandwidth (BW), and monetary cost(C) of candidate networks as input parameters. And the weight of each QoS metrics is adjusted along with the networks changing to trace the network condition. The final optimized vertical handoff decision is made by comparing the quantitative decision values of the candidate networks. Simulation results demonstrate that the proposed algorithm provides high performance in heterogeneous as well as homogeneous network environment.
Results on Plasma Focusing of High Energy Density Electron and Positron Beams (2000)

We present results from the SLAC E-150 experiment on plasma focusing of high energy density electron and, for the first time, positron beams. We also discuss measurements on plasma lens-induced synchrotron radiation, longitudinal dynamics of plasma focusing, and laser- and beam-plasma interactions.
Highly sensitive and specific noninvasive in-vivo alcohol detection using wavelength-modulated differential photothermal radiometry (2018)

This paper reports the application of wavelength modulated differential photothermal radiometry (WM-DPTR) to blood alcohol (ethanol) concentration (BAC) measurements in the mid-infrared range to prevent impaired driving. <i>In-vivo</i> alcohol consumption measurements performed in the BAC range of interest (0-80 mg/dl) with an optimal wavelength pair demonstrated the alcohol detection capability of WM-DPTR with high resolution (~5 mg/dl) and a low detection limit (~10 mg/dl). Oral glucose tolerance tests using both glucose and alcohol sensitive wavelength pairs in the normal-to-hyperglycemia range (~80-320 mg/dl) proved the blood glucose screening ability and ethanol detection specificity of WM-DPTR. The immunity of WM-DPTR to temperature and glucose variation makes the differential signals alcohol sensitive and specific, yielding precise and accurate noninvasive alcohol measurements in the interstitial fluid.
A Gait Analysis: Patients of Hip Ankylosis (2004)

The gait of five patients with unilateral hip ankylosis was analyzed in terms of distribution of foot pressure, stance phase rate (stance phase/gait cycle), step length, and foot angle. There was no relation between leg length discrepancy and talipes equinus. The ankylosing side was significantly shorter than the normal side for stance phase duration. There was no significant difference between the ankylosing side and normal side for step length.Interrelation was seen between the foot angle and external rotation angle of the ankylosing hip.
Effect of extracellular acidosis on 45Ca uptake in isolated hypoxic proximal tubules (1988)

Recent in vitro studies have suggested that the presence of extracellular acidosis is protective against the development of oxygen-deprivation injury in several tissues. Because cellular Ca accumulation after renal ischemia may represent a major pathogenic event leading to cellular damage, the purpose of the present study was to examine the effect of extracellular acidosis on 45Ca uptake and desaturation in normal and hypoxic isolated rat proximal tubules. At pH 7.4, an increase in 45Ca uptake was observed in proximal tubules after 30 min of hypoxia. In addition, 45Ca desaturation was increased significantly in hypoxic tubules at pH 7.4. The alterations in 45Ca uptake and desaturation in hypoxic tubules at pH 7.4 were accompanied by significant signs of cellular injury as assessed by the amount of lactate dehydrogenase (LDH) released by the tubules at the end of the hypoxic period (22.5% above control tubules, P less than 0.01) as well as in morphological changes consistent with hypoxic cell injury. In contrast, when maintained at pH 6.9 throughout the study, no difference in 45Ca uptake or desaturation was observed between the control and hypoxic tubules; the hypoxic proximal tubules exhibited a smaller increase in LDH release (12.7% above control tubules) and did not develop the morphological changes observed at pH 7.4. Thus, during hypoxia and reoxygenation at pH 7.4, the increased 45Ca uptake may contribute in part to cellular injury in rat proximal tubules.
Analysis and calculation on the microwave radiation characteristic of aerial target (2011)

Under actual threat of aerial target, to enhance survivability of ground military targets in future battlefield, to detect aerial stealth targets by a microwave (MW) radiometer, a research on the microwave radiation characteristic of aerial stealth target is conducted. First, stealth targets radiation characteristic of radar absorbing material (RAM) is analyzed. Second, influence of atmosphere on radiation propagation is analyzed and finally a microwave radiation and propagation model is proposed. Simulation analyzed and calculated the microwave radiation characteristic of aerial stealth target and proved this model is effective.
A Na(+)-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. cDNA cloning and functional expression. (1993)

A cDNA has been cloned from rabbit brain that is a new member of the emerging family of Na(+)-dependent plasma membrane transporters for several neurotransmitters and structurally related compounds. Functional expression of this cDNA in COS-7 cells identifies its product as a Na(+)- and Cl(-)-dependent creatine transporter with a Km of approximately 35 microM. Its creatine transporter activity is efficiently antagonized by 3-guanidinopropionate, a well characterized alternative substrate of creatine transport in several tissues, and by 4-guanidinobutyrate. More distant structural analogues of creatine are much less efficient or inactive as antagonists, indicating a high substrate specificity of the transporter. Northern blot hybridization detects the expression of its mRNA in most tissues tested, most prominently in kidney, heart, and muscle, but not in liver and intestine. A full-length cDNA clone was also isolated from a muscle cDNA library and found to contain the same coding sequence. Substrate affinity and specificity of the cloned transporter are very similar to the endogenous creatine transporter of the COS-7 cells and to the creatine transport activities of several cell types described in the literature. Moreover, its mRNA is most abundant in the tissues known to possess high creatine uptake capacity.
Toehold-Mediated Nonenzymatic DNA Strand Displacement As a Platform for DNA Genotyping (2013)

Toehold-mediated DNA strand displacement provides unique advantages in the construction and manipulation of multidimensional DNA nanostructures as well as nucleic acid sequence analysis. We demonstrate a step change in the use of toehold-mediated DNA strand displacement reactions, where a double-stranded DNA duplex, containing a single-stranded toehold domain, enzymatically generated and then treated as a molecular target for analysis. The approach was successfully implemented for human DNA genotyping, such as gender identification where the amelogenin gene was used as a model target system, and detecting single nucleotide polymorphisms of human mitochondrial DNA. Kinetics of the strand displacement was monitored by the quenched Förster resonance energy transfer effect.
Cathepsin D as a Promising Target for the Discovery of Novel Anticancer Agents (2017)

Background: Cathepsin D (CATD), one of the aspartyl endoproteinase involved in different physiological processes and signaling pathways, is accountable for metabolic breakdown of intracellular proteins, the activation of growth factors, hormones, and precursors of enzyme, the processing of antigens, enzyme inhibitors and activators and the regulation of apoptosis. Keywords: Aspartic protease, cancer, cathepsin D, chemoprevention, natural products, apoptosis.
Supplementary Table 1 from Antibody-Targeted Chemotherapy for the Treatment of Melanoma (2023)

&lt;p&gt;Mouse toxicity study of organs from 3 mice in each treatment group.&lt;/p&gt;
Observation of MOSFETs without bias voltage using a laser-THz emission microscope (2006)

For inspecting electrical failures in large-scale integration circuits (LSI), we developed a laser-THz emission microscope (LTEM), which records the map of the THZ emission amplitude in a sample upon excitation with fs laser pulses. We successfully obtained the THz emission image of MOSFETs fabricated in a test element group without bias voltage. We also measured MOSFETs in which the connection lines from the electrodes to the p-n junctions were interrupted, and found that the polarity of the temporal waveform of the THz emission from the p-n junction in damaged MOSFETs has the opposite sign compared to that in normal MOSFETs. This result indicates that the LTEM is a potential tool for the inspection of MOSFETs without bias voltage, which is the advantage for the failure analysis of semiconductor devices during the manufacturing process.
Utilization of SECDED for soft error and variation-induced defect tolerance in caches (2007)

Combination of SECDED with a redundancy technique can effectively tolerate a high variation-induced defect rate in future processes. However, while a defective cell in a block can be repaired by SECDED, the block becomes vulnerable to soft errors. This paper proposes a technique to deal with the degraded resilience against soft errors. Only clean data can be stored in defective blocks of a cache. This constraint is enforced through selective write-through mechanism. An error occurring in a defective block can be detected and the correct data can be obtained from the lower level caches.
An Empirical Investigation Into The Administrative Procedures Taken In Response To The Detection Of Medical Errors Within Acute Care Hospitals In Pennsylvania (2011)

This researcher investigates the procedures taken by healthcare administrators within Pennsylvania acute care hospitals with respect to the detection of medical errors in order to provide corrective measures. In response to structured interview questions, the overwhelming majority of research participants stated that the procedures for corrective actions focused upon various training interventions as deemed appropriate by management. However, scholarly literature states that the majority of medical errors do not occur due to the lack of competence, skills, or knowledge of healthcare professionals. Thus, using training interventions to solve non-training problems may not prove effective. The outcome of the study has lead to several important implications for the healthcare industry. Lastly, further research was suggested as it relates to patient safety and the reduction of medical errors.
Targeting the MYC Oncogene in Burkitt Lymphoma through HSP90 Inhibition (2018)

Overexpression of the MYC oncogene is a key feature of many human malignancies including Burkitt lymphoma. While MYC is widely regarded to be a promising therapeutic target, a clinically effective MYC inhibitor is still elusive. Here, we report an alternative strategy, targeting MYC indirectly through inhibition of the HSP90 machinery. We found that inhibition of HSP90 function reduces MYC expression in human Burkitt lymphoma through suppression of MYC transcription and destabilization of MYC protein, thereby diminishing the proliferation of tumor cells. Consistently, treatment of Burkitt lymphoma cell lines with HSP90 inhibitors (17-AAG or 17-DMAG) was accompanied by downregulation of canonical MYC target genes. Combination treatment with 17-DMAG and the proteasome inhibitor, MG-132, led to accumulation of MYC protein, indicating that upon HSP90 inhibition, MYC is degraded by the proteasome. Using co-immunoprecipitation, we furthermore demonstrated a direct interaction between MYC and HSP90, indicating that MYC is an HSP90 client protein in Burkitt lymphoma. Together, we report here the use of HSP90 inhibitors as an alternative approach to target the MYC oncogene and its network in Burkitt lymphoma.
Meta-analysis on hypomethylating agents in myelodysplastic syndromes (2009)

important addition to and complement the systematic review by Gurion et al. 1 They provide greater precision to the existing results and the supplemental analyses, which in turn will be helpful in making informed decisions
Reorganization of Visual Processing in Age-Related Macular Degeneration Depends on Foveal Loss (2014)

We conclude that complete loss of foveal function may be a necessary condition for large-scale reorganization of visual processing in individuals with MD.
Muscarinic Receptor Activation Promotes the Membrane Association of Tubulin for the Regulation of Gq-Mediated Phospholipase Cβ1Signaling (2000)

The microtubule protein tubulin regulates adenylyl cyclase and phospholipase Cbeta(1) (PLCbeta(1)) signaling via transactivation of the G-protein subunits Galphas, Galphai1, and Galphaq. Because most tubulin is not membrane associated, this study investigates whether tubulin translocates to the membrane in response to an agonist so that it might regulate G-protein signaling. This was studied in SK-N-SH neuroblastoma cells, which possess a muscarinic receptor-regulated PLCbeta(1)-signaling pathway. Tubulin, at nanomolar concentrations, transactivated Galphaq by the direct transfer of a GTP analog and potentiated carbachol-activated PLCbeta(1). A specific and time-dependent association of tubulin with plasma membranes was observed when SK-N-SH cells were treated with carbachol. The same phenomenon was observed with membranes from Sf9 cells, expressing a recombinant PLCbeta(1) cascade. The time course of this event was concordant both with transactivation of Galphaq by the direct transfer of [(32)P]P(3)(4-azidoanilido)-P(1)-5'-GTP from tubulin as well as with the activation of PLCbeta(1). In SK-N-SH cells, carbachol induced a rapid and transient translocation of tubulin to the plasma membrane, microtubule reorganization, and a change in cell shape as demonstrated by confocal immunofluorescence microscopy. These observations presented a spatial and temporal resolution of the sequence of events underlying receptor-evoked involvement of tubulin in G-protein-mediated signaling. It is suggested that G-protein-coupled receptors might modulate cytoskeletal dynamics, intracellular traffic, and cellular architecture.