gebhart/patrepeval huggingface dataset:
Abstract 13306: Impella Combined With Extracorporeal Membrane Oxygenation Synergistically Unloads the Left Ventricle and Reduces Infarct Size in a Model of Myocardial Infarction With Cardiogenic Shock (2020)

Introduction: Extracorporeal membrane oxygenation (ECMO) supports hemodynamics in cardiogenic shock (CS) at the expense of left ventricular (LV) overload. LV assist device (LVAD) also supports hemodynamics, whereas LVAD unloads LV. Therefore, the combination of ECMO and LVAD would augment hemodynamic support and unload LV. We hypothesized that the combination therapy in acute myocardial infarct (AMI) in CS could synergistically improve hemodynamics and unload LV, which, in turn, reduces infarct size. Methods: In protocol 1, we ligated coronary arteries and created AMI with CS in 5 mongrel dogs (15.1±0.3 kg). We transvascularly introduced Impella CP into LV. We kept the ECMO flow constant at 1.8L/min. We compared hemodynamics and the LV pressure-volume area (PVA, an index of LV oxygen consumption) under 3 conditions; Control, ECMO, and ECMO+Impella (ECPELLA) in each dog. In protocol 2 (n=15), we ligated coronary arteries for 180 min and then reperfused. We activated Impella CP and/or ECMO from 60 min after the coronary ligation to the end of the experiment. We allocated dogs into 3 groups, no support (Control), ECMO, and ECPELLA and compared infarct size at 180 min after reperfusion among 3 groups. Results: In protocol 1, both ECMO and ECPELLA increased arterial pressure compared to Control (Control: 63±9, ECMO: 88±10 and ECPELLA: 97±18 mmHg, p &lt; 0.05), and resolved the CS status. ECPELLA strikingly reduced PVA by 83% relative to Control (1500±326, 2038±357 and 258±182 mmHg*ml, p&lt;0.001). In protocol 2, ECPELLA markedly reduced the infarct size (15±8%) compared to Control (53±7%, p&lt;0.05) and ECMO (39±10%, p&lt;0.05). Conclusions: ECPELLA before reperfusion markedly improved hemodynamics, reduced PVA, and limited infarct size in a dog model of MI with CS. ECPELLA could prevent ECMO-induced LV overload and synergistically exert powerful anti-infarct effects in AMI with CS.
Begriffsbildung nach ISO/IEC 27000 (2022)

No AccessPraxisbuch ISO/IEC 27001Oct 2022Begriffsbildung nach ISO/IEC 27000Michael Brenner, Nils gentschen Felde, Wolfgang Hommel, Stefan Metzger, Helmut Reiser, Thomas SchaafMichael Brenner, Nils gentschen Felde, Wolfgang Hommel, Stefan Metzger, Helmut Reiser, Thomas Schaafhttps://doi.org/10.3139/9783446474581.008SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2022Pages: 169-185Print ISBN: 978-3-446-47395-9eISBN: 978-3-446-47458-1 Copyright & Permissions© 2022 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Visualization of Membrane Sorting and Fusion in Living Cells using Total Internal Reflection (TIR) and Multicolor Video Microscopy (2001)

Abstract Post-Golgi sorting of different classes of newly synthesized proteins and lipids is central to the generation and maintenance of cellular polarity. to directly visualize the dynamics and location of apical/basolateral sorting and trafficking we used fast time-lapse multicolor video microscopy in living cells. Specifically, green fluorescent protein color variants (cyan, CFP; yellow, YFP) of apical cargo (GPI-anchored) and basolateral cargo (vesicular stomatitis virus glycoprotein, VSVG) were generated; see FIG 1. Fast dual color fluorescence video microscopy allowed visualization with high temporal and spatial resolution. Our studies revealed that apical and basolateral cargo progressively segregated into large domains in Golgi/TGN structures, excluded resident proteins, and exited in separate transport containers. These carries remained distinct and did not merge with endocytic structures en route to the plasma membrane. Interestingly, our data suggest that the primary sorting occurs by lateral segregation in the Golgi, prior to budding (FIG 2). Further characterization of morphological differences of apical versus basolateral transport carriers was achieved using a specialized microscopy technique called total internal reflection (TIR) microscopy. with this approach only the bottom of the cell (&amp;lt;100 nm) was illuminated by an exponentially decaying evanescent “wave” of light. A series of images, taken at ∼1 second intervals, shows a bright “flash” of fluorescence when the vesicle fuse with the plasma membrane and the fluorophore diffuses into the plasma membrane (FIG 3).
Standard Needle Magnetization for Ultrasound Needle Guidance: First Clinical Experiences in Fine‐Needle Aspiration Cytology of Thyroid Nodules (2019)

Fine-needle aspiration cytology using a novel ultrasound needle guidance system on the basis of standard needle magnetization was consecutively performed in 30 (15 in-plane and 15 out-of-plane) suspicious thyroid nodules. Nondedicated, commercially available needles were used. The technical effectiveness and safety of the system were satisfying; system failures were observed in 2 cases. The needle tip could be (at least occasionally) visualized inside the thyroid nodule in 96%, and the subjective procedure ratings were excellent in 57%. The out-of-plane technique was significantly superior in both respects (P = .021 and .027, respectively). Standard needle magnetization ultrasound needle guidance was easy to apply and cost-effective and has the potential to improve fine-needle aspiration cytology performance.
Novel decoupled six-axis force robot sensor (2004)

In order to get the force information on the feet of the biped robot imitating human walking and simplify the force being measuring system, a force sensor which is suitable for being mounted on the feet of the biped robot imitating human walking and force decoupled is demanded. A novel elastic body is designed and analyzed by ANSYS software package. According to the theory of stress measurement, a novel force decoupled six-axis force sensor was developed through a specified scheme of the distribution of strain gauges and the makeup of electric bridge of strain gauges. The experiment results of the prototype of the novel sensor are given, and they show that the sensor' s sensitivity reaches 1. 26 μV/N, its linearity reaches 2.0%, and the coupling or the output forces is lower than 5. 0%.
Simulations of Grinding Process based on the Model of Wheel Surface Characteristics (1979)

(1) ミニコンピュータを使って, 砥粒切れ刃の基本挙動にのっとった研削過程のシミュレーションが実行され, 研削実験結果と比較検討された.(2) 砥石の粒度, 結合度, ドレッシング条件, 砥石切込み量, 砥材特性などの入力条件が広範囲に変化しても, シミュレーションは研削実験とかなり良く一致し, モデルの妥当性と実用性が確かめられた.(3) この種のモデルの精度向上と対象範囲拡張のための課題が検討された.
Chapter 17 (2010)

Abstract This chapter discusses the author's rework of her 1989 installation art work called Dialogue. During this time the author learned from Lan Jun's uncle the true reason why he had told her that he did not need her anymore and she admitted her mistake of laying the foundation for his opportunism. With the help of Zhao Xiaoshu and Ju Qing, the author completed the reproduction of Dialogue in January 2004. She also had the opportunity to meet Gao Tianyu and explain to him the motivation for the 1989 shooting performance.
Interpretation of definite noun phrases (1991)

The paper addresses the referential properties of definite NPs and introduces a homogeneous framework for coping with ambiguities in reference and with the generic/specific and referential/attributive dichotomies. The basic assumption is that an ambiguous &amp;amp;quot;logical form&amp;amp;quot; is the most reasonable tool for carrying out the interpretation process without propagating existing ambiguities in unnecessary ways. The ambiguities in reference arc shown to be analyzable perspicuously in terms of three independent parameters: the context, the world, and the time in which the sentence is used. Different readings of NPs arise from the fixing of one or more of these parameters, going from the most general (the &amp;amp;quot;intension &amp;amp;quot; or &amp;amp;quot;concept&amp;amp;quot;, where nothing is fixed) to the least general (the usual &amp;amp;quot;definite specific &amp;amp;quot; reading, where all the parameters are fixed). Beyond the ambiguities in reference, the distinction between collective and distributive readings and the one between the readings we call relational and non relational arc analyzed and the relationships among the different kinds of ambiguities arc examined. 1
Biographia dramatica, or, A companion to the playhouse : containing historical and critical memoirs, and original anecdotes, of British and Irish dramatic writers from the commencement of our theatrical exhibitions ... (2011)

Book digitized by Google from the library of the University of Michigan and uploaded to the Internet Archive by user tpb.
Cytotoxicity, Regulation of Apoptotic and Anti-apoptotic Gene Expression by IL-27 in MCF-7 and MDA-MB-231 Breast Cancer Cell Lines (2018)

Breast cancer is one of the commonest cancers among women. Conventional therapies cause adverse side effects in patients. Cytokine immunotherapy such as interleukin-27 (IL-27) has been sought as an alternative cancer treatment in recent years. IL-27 has been shown to improve anticancer immunity and anti-angiogenesis in cancers, however, its effect on apoptotic and anti-apoptotic gene expression especially in breast cancers is yet to be explored. Cytotoxicity of IL-27 in non-cancerous (184b5) and cancerous breast cell lines was first determined for 24-72 h in this study. The results indicated that IL-27 treatment did not retard 184b5 cell growth, however, did inhibit MCF-7 (48 h) and MDAMB-231 (72 h) cell growth with IC50 at 442 and 457 ng/ml, respectively. Apoptotic (TRAIL, FADD, FAS, caspase-3 and caspase-8) and anti-apoptotic (BCL-2, AKT, and COX-2) genes were then amplified from untreated (control) and treated breast cancer cells and studied. TRAIL, caspase-3, caspase-8 gene expression was significantly (p &lt; 0.05) upregulated in treated MCF-7 (442 ng/ml) and MDA-MB-231 (457 ng/ml) cells. Expression of FADD and FAS genes was not detected in both control and treated MCF-7 and MDA-MB-231 cells. COX-2 gene was also not expressed by MCF-7 cells, but reduced significantly (p &lt; 0.05) in treated MDA-MB-231 cells. In MDA-MB-231 cells, IL-27 treatment seemed to slightly enhance the expression of AKT and BCL-2 genes which, on the other hand, was downregulated in treated MCF-7 cells. Conclusively, IL-27 is able to inhibit breast cancer cell growth and regulate apoptotic and anti-apoptotic gene expression in breast cancer cells. DOI : http://dx.doi.org./10.17576/JSKM-2018-03
Cannabinoid Receptor 2 and C-X-C Chemokine Receptor 4 Interact to Abrogate CXCL12-Mediated Cellular Response (2017)

The expression of C-X-C Chemokine Receptor 4 (CXCR4) has been correlated with increased metastatic potential of cancer cells. CXCR4 increases tumor malignancy by encouraging tumors cells to migrate to distal organs expressing its cognate ligand, CXCL12, facilitating metastasis. Thus, targeting the CXCR4/CXCL12 signaling axis provides a good strategy to inhibit the metastatic spread of tumor cells and slow cancer progression. Various studies suggest that cannabis may have anti-proliferative as well as anti-metastatic properties, though a biochemical mechanism describing how this occurs has yet to be discovered. Our lab has confirmed that agonist-bound CXCR4 and agonist-bound Cannabinoid Receptor 2 (CB2) can form heterodimers that play a role in decreasing cancer cell migration. Simultaneous treatment of the breast cancer cell line, MDA-MB-231 and the prostate cancer cell line PC-3, with CXCL12 and AM1241, a synthetic ligand for CB2, desensitizes the intrinsic cellular response to migrate toward areas of high CXCL12 concentration. Furthermore, through co-immunoprecipitation and\nproximity ligation assays (PLA), we have determined that there is increased interaction between the two receptors with co-stimulation of respective agonists, providing evidence for the therapeutic notion that treating tumors that endogenously secrete CXCL12 with exogenous ligands for the cannabinoid can induce dimerization. Moreover, when CXCR4 and CB2 were activated simultaneously with various agonists, decreases in migration were observed, confirming that the regulatory activity was receptor-based, not agonist-based. Finally, to determine whether simultaneously–treated, dimerized receptors inhibited activity of respective receptors, calcium mobilization assays to determine G-protein coupled receptor activation were employed. Results showed that transiently activated calcium levels were significantly lower in response to simultaneous treated cells when compared to cells treated with their individual ligands. Phosphorylation of ERK and AKT were abrogated in response to simultaneous stimulation indicating loss in downstream signaling. Therefore, we believe that the interaction of CB2 with CXCR4 may play a role in inhibiting the cells response to CXCL12, leading to a loss in metastatic potential of cells expressing these receptors.
Viscosity Stability of Aqueous Polysaccharide Solutions (1983)

Abstract The viscosity stability of carbohydrate polymers under thermal-oxidative, mechanical and acid-catalyzed hydrolysis is examined and compared with the performance of a synthetic water-soluble polymer, hydrolyzed (30%) poly(acrylamide) (HPAM). Under thermal-oxidative conditions HPAM is the most stable polymer and the carbohydrate polymers prepared by fermentation systhesis (i.e., Xanthan gum (XCPS) or Sclerotium glucanicum polysaccharide, (SGPS) are more stable than non-fermentation polysaccharides (i.e., guar gum, hydroxyethyl cellulose, cellulose sulfate ester, etc.). In acid catalyzed hydrolysis the same differential performance between fermentation and non-fermentation carbohydrate polymers is observed. This difference is correlated with an ability to form helical aggregates which protects the repeating acetal linkage in carbohydrate polymers from oxygen and proton attack. Additives that disrupt hydrogen bonding among pyranose units and therefore disrupt helical aggregate structures in fermentation polymers decrease their solution viscosity stabilities. A molecular weight dependence is not observed under either thermaloxidative or acid catalyzed degradation conditions, but a dependence is observed in mechanical degradation. Lower molecular weight polymers are more stable. For mechanical stability, a rigid-rod conformation is sufficient for stability; some non-fermentation polymers exhibit stability equivalent to fermentation polymers. Less mechanically stable carbohydrate polymer solutions (i.e., hydroxyethyl cellulose, xanthan gum in a 4M urea or SGPS in alkaline solutons) are more stable than conformationally and segmentally flexible synthetic water-soluble polymers (i.e., HPAM or polyethylene oxide). The influence of oxygen as an antagonist to polymer stability is investigated in the presence of two stabilizing additives, magnesium oxide (MgO) and tetraethylenepentamine (TEPA). In oxygen saturated solutions thickened with non-fermentation carbohydrate polymers, both function effectively, primarily by inhibiting the formation of hydroperoxide groups. In aqueous systems containing oxygen scavengers, MgO is ineffective; TEPA continues to be effective due to its ability to chelate transition metals, modify the scavenger's activity and intercede in the synergistic interaction of these activators with oxygen. The use of either of these additives in field applications can result in well bore problems.
A hybrid ad hoc networking protocol for disaster recovery resource management (2018)

Following a major disaster, the infrastructure supporting wired and mobile networking is expected to be inoperable over large areas. Thus, emergency response teams must communicate using their own networking equipment. A large-scale peer-to-peer network offers fast and flexible deployment but requires cooperation among nodes. Usage constraints must be imposed to prevent overloading the shared network capacity. In particular, disparate communication models (for route building and optimisation, resource management, and localised status flooding) must be integrated. We propose a hybrid network protocol which dynamically assigns network capacity to these three communication models by imposing transmission delays in accordance with their attempted usage rates.
The interaction of surface and dust particle size on the pick‐up and grooming behaviour of the German cockroach Blattella germanica (1995)

Abstract The relationship between the particle size of an inert silica dust, its up‐take from different surfaces and the grooming behaviour of males, gravid females, and fifth and sixth instar nymphs of the German cockroach Blattella germanica (Dictyoptera: Blattellidae) (L.) was investigated. The normal grooming behaviour of gravid females, nymphs and males differed according to sex and age. The gravid females and nymphs exhibited greater grooming activity than the males, especially of the antennae and the legs. Gravid females, nymphs, and adult males exhibited increased grooming activity after exposure to dust in the size range 0.5–63 μm, but there was no significant difference in grooming behaviour from the control when cockroaches were exposed to dust sizes greater than 70 μm. Antennal grooming by males was greater than leg grooming when exposed to all dust sizes, except size particles ranging 4.5–7.5 μm. A dust pick‐up experiment indicated that the average amount of dust transferred to B. germanica is affected by particle size, the porosity of the treated surface, and the sex and age of the cockroaches. Gravid females picked up greater amounts of dust than fifth and sixth instar nymphs, which in turn picked up more dust than males. Silica dust particles (0.5–7.5 μm) were picked up more effectively than larger particle sizes, by all three categories, males, females and fifth and sixth instar nymphs of cockroach on all three test surfaces plastic, ceramic and unpainted plywood. Plywood was the least effective surface for transfer of dust, of all sizes, to males, females and nymphs.
Synthesis and characterization of alkylated N‐vinylformamide monomers and their polymers (2004)

Abstract N ‐alkyl‐ N ‐vinylformamide monomers (alkyl: n ‐butyl, hexyl, decyl, and dodecyl) are synthesized in two steps: first, preparation of N ‐vinylformamide potassium salt by the reaction of N ‐vinylformamide (NVF) with potassium t ‐butoxide, then reaction with alkyl bromide. All four monomers are liquid and are characterized by IR, 1 H NMR, 13 C NMR, and mass spectra. They exist as rotomers in solution and a 2D NOE experiment on the N ‐hexyl containing polymer shows the E isomer to be favored. The polymerizability of the four monomers is from good to fair, depending upon the length of alkyl chain on the N ‐atom‐‐the longer the chain length, the lower lower the polymerizability of monomer. The hydrolysis of poly( N ‐hexyl‐ N ‐vinylformamide) and poly( N ‐dodecyl‐ N ‐vinylformamide) under acidic and basic conditions was examined. Studies show that hydrolytic cleavage of formyl groups of poly ( N ‐alkylated‐ N ‐vinylformamide) depends on the hydrophobicity of the alkyl substituent on the N ‐atom under acidic conditions; both polymers were hydrolyzed to only a minor extent under alkaline conditions. The N ‐alkylated monomers can copolymerize with NVF and demonstrate amphiphilic properties. The copolymers demonstrate a critical aggregation concentration above which they can solubilize a water insoluble dye; the N ‐hexyl containing copolymer stabilizes a castor oil‐in‐water emulsion. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 4994–5004, 2004
High power dense electric propulsion motors (2013)

The paper describes the results of design and analysis studies performed by the authors for comparison of predicted performance of an electric propulsion motor using conventional and emerging technologies. Specifically, a modern squirrel cage induction motor design is compared to both a permanent magnet motor with high energy magnets and a high temperature superconducting motor using second generation superconductor. The selected baseline design is a ship propulsion motor in operation rated at 5000 HP 1800 RPM. The results of calculated performance and comparative studies among the various technologies show great potential for increasing the power density using the second generation high temperature superconducting technology. Using the currently available second generation superconductor current capabilities, the achieved power density of the propulsion motor is over twice that of the induction motor. Further investigations are being carried out to improve the superconductor performance for future designs for an on-going project sponsored by the United States Department of Energy to reduce the cost of the superconductor for future commercial applications of the high temperature superconducting technology.
Fluxless Lead-Free Soldering Process Employing Vacuum Technology (2012)

Owing to the increase in environmental consciousness, various environmental regulations have been enforced in the recent past. In particular, the use of lead in soldering technology has been forbidden by RoHS directives. Furthermore, manufacturing or import of chemical substances such as flux, which are used in the soldering process, may be restricted in EU. It may be difficult to change production methods for complying with these regulations by simply changing the materials used or improving the methods themselves. This paper presents several examples of dramatic improvement in soldering process through the employment of vacuum technology. In processes employing this technology, voids in a solder could be removed by varying pressure during solder melting. Moreover, melting solder in a hydrogen atmosphere or formic atmosphere accompanied by pressure variation renders the soldering process fluxless. The two above-mentioned methods adapt to die bonding process of power device which has a wide bonding area. Finally, we describe in detail the application of hydrogen radicals to solder bumps which have a diameter less than 1 mm. We found that hydrogen radicals not only reduce the oxide films of the solder but also inhibit the reoxidation.
Evaluating an Emergency Medical Services—Initiated Nontransport System (2006)

Age is a determinant when deciding on transporting patients. Patients with complaints with potentially higher acuity were transported most often. Only two nontransported patients died within 30 days, although it is unknown whether initial transport would have changed their mortality. Our data suggest that emergency medical services-initiated nontransport is influenced only by age and chief complaint and may not result in significant mortality.
Multi-frequency Phase Unwrapping for Time-of-Flight cameras (2010)

Time-of-Flight (ToF) cameras gain depth information by emitting amplitude-modulated near-infrared light and measuring the phase shift between the emitted and the reflected signal. The phase shift is proportional to the object's distance modulo the wavelength of the modulation frequency. This results in a distance ambiguity. Distances larger than the wavelength are wrapped into the sensor's non-ambiguity range and cause spurious distance measurements. We apply Phase Unwrapping to reconstruct these wrapped measurements. Our approach is based on a probabilistic graphical model. We use loopy belief propagation to detect and infer the position of wrapped measurements. Besides depth discontinuities, our method utilizes multiple modulation frequencies to identify wrapped measurements. In experiments, we show that wrapped measurements are identified and corrected, even in situations where the scene shows steep slopes in the depth measurements.