gebhart/patrepeval huggingface dataset:
A multistate modeling approach to investigate long-term effects of claw horn disruption lesions and early lesion development in dairy cows (2023)

Claw horn disruption lesions (CHDL) are a leading cause of lameness in dairy cattle, and the development, effect, and pathology of these lesions remains an open area of interest within dairy cattle health. Current literature typically attempts to measure the effect of risk factors on the development of CHDL over a relatively short time period. Further understanding of the interaction of CHDL and the long-term effect of early CHDL in a cow's life remains an important area of research which is so far mostly unexplored. In this study 57,974 cows from 1,332 herds were selected and their regular claw trimming records containing important claw health information were used to model the long-term effect of lesions in a cow's lifetime in a 6-state multistate model. A multistate model predicts the time before transition from any one state to another and the probability of transition to a future state. The 6 lesion states that were modeled were as follows: never had a lesion, first recorded lesion event, no recorded lesion after first lesion event, second or subsequent recorded lesion event, no recorded lesion after second or subsequent lesion event, and culled. The effect of various cow level covariates on the transition probabilities between various states was tested. For the first time, this study shows the importance and effect of the first lesion and other cow level factors on long-term claw health. Model results showed that the timing and severity of the first recorded lesion event significantly influenced the likelihood of a future lesion being present. Cows with CHDL present within the 180 d of first calving had a short-term increased risk and long-term decreased risk of a future lesion, compared with cows that present with CHDL later than 180 d of first lactation. Moreover, presence of a severe first lesion increased a cow's risk of a future lesion being present. The model was used to evaluate the relative difference between high-risk cows (age of first calving ≥793 d, breeding values in the lowest quartile) and low-risk cows (age of first calving ≤718 d, breeding values in the highest quartile). Our results indicated that these low-risk cows present with a lesion on an average 3 mo later than high-risk cows. Furthermore, results from the model evaluation of a simulated herd with cows with breeding values in the higher quartile indicated that cows present with a CHDL on an average 7.5 mo later compared with a herd where cows have breeding values distributed in a lower quartile.
Surface Normal Overlap: A Computer-Aided Detection Algorithm With Application to Colonic Polyps and Lung Nodules in Helical CT (2004)

We developed a novel computer-aided detection (CAD) algorithm called the surface normal overlap method that we applied to colonic polyp detection and lung nodule detection in helical computed tomography (CT) images. We demonstrate some of the theoretical aspects of this algorithm using a statistical shape model. The algorithm was then optimized on simulated CT data and evaluated using a per-lesion cross-validation on 8 CT colonography datasets and on 8 chest CT datasets. It is able to achieve 100% sensitivity for colonic polyps 10 mm and larger at 7.0 false positives (FPs)/dataset and 90% sensitivity for solid lung nodules 6 mm and larger at 5.6 FP/dataset.
A novel and efficient route to (E)-alk-1-enyl boronic acid derivatives from (E)-1-(trimethylsilyl)alk-1-enes and a formal Suzuki–Miyaura cross-coupling reaction starting with vinylsilanes (1995)

A novel and highly efficient conversion of vinylsilanes into vinyl boronates is described together with their Suzuki–Miyaura cross-coupling reaction, performed without isolating the intermediate resulting from borodesllyiation.
Treatment of “static shifts” in multitransient electromagnetic (MTEM) data (2007)

All electromagnetic, EM, methods, including the MTEM method, are susceptible to “static shifts”. We first discuss the nature of the shifts in MTEM data by reference to 3D synthetic modelling. We then show that impulse responses, normalized by the peak values provide a dataset which has had these shift effects removed. Hence giving a method which allows MTEM data to be successfully combined for 1D inversion, where “static shifts” had been present in the input data.
Review of US and EU initiatives toward development, demonstration, and commercialization of lignocellulosic biofuels (2013)

Following publication of the above article (DOI 10.1002/bbb.1436) in Wiley Online Library on 9 August 2013, and in the present issue of the Biofuels, Bioproducts and Biorefining (7: 732–759), it was found that the information below was accidentally omitted from Table 2 (pp. 740–745): Company: UPM Proj.Acron.: Lappeenranta biorefinery EU Site: EU - Lappeenranta (FI) Type (Technology): Commercial (hydrotreatment) Product(s): Renewable diesel (by hydrotreatment) - commercial name UPM BioVernoInstalled Capacity: 100 000 t/y renewable diesel Feedstock: Crude Tall Oil (CTO) Status: Production starts 2014 Feesdtock: CTO is a residue from chemical pulp process, originating from raw sulphate soap separated from black liquor Manufacturing process of renewable diesel is based on UPM innovation and consists of following main process sections pretreatment of crude tall oil, hydrotreatment, recycle gas purification, fractionation Renewable diesel is drop-in fuel (hydrocarbon), compatible with fossil diesel EN590 standard quality and has no blending limit
Design Strategies, Practical Considerations, and New Solution Processes of Sulfide Solid Electrolytes for All‐Solid‐State Batteries (2018)

Abstract Owing to the ever‐increasing safety concerns about conventional lithium‐ion batteries, whose applications have expanded to include electric vehicles and grid‐scale energy storage, batteries with solidified electrolytes that utilize nonflammable inorganic materials are attracting considerable attention. In particular, owing to their superionic conductivities (as high as ≈10 −2 S cm −1 ) and deformability, sulfide materials as the solid electrolytes (SEs) are considered the enabling material for high‐energy bulk‐type all‐solid‐state batteries. Herein the authors provide a brief review on recent progress in sulfide Li‐ and Na‐ion SEs for all‐solid‐state batteries. After the basic principles in designing SEs are considered, the experimental exploration of multicomponent systems and ab initio calculations that accelerate the search for stronger candidates are discussed. Next, other issues and challenges that are critical for practical applications, such as instability in air, electrochemical stability, and compatibility with active materials, are discussed. Then, an emerging progress in liquid‐phase synthesis and solution process of SEs and its relevant prospects in ensuring intimate ionic contacts and fabricating sheet‐type electrodes is highlighted. Finally, an outlook on the future research directions for all‐solid‐state batteries employing sulfide superionic conductors is provided.
Effect of increasing inoculum sizes of pathogenic filamentous fungi on MICs of antifungal agents by broth microdilution method (1995)

Inoculum size is a critical variable in development of methods for antifungal susceptibility testing for filamentous fungi. In order to investigate the influence of different inoculum sizes on MICs of amphotericin B, 5-fluorocytosine, itraconazole, and miconazole, 32 clinical isolates (8 Aspergillus fumigatus, 8 Aspergillus flavus, 5 Rhizopus arrhizus, 8 Pseudallescheria boydii, and 3 Fusarium solani isolates) were studied by the broth microdilution method. Four inoculum sizes were studied: 1 x 10(2) to 5 x 10(2), 1 x 10(3) to 5 x 10(3), 1 x 10(4) to 5 x 10(4), and 1 x 10(5) to 5 x 10(5) CFU/ml. The National Committee for Clinical Laboratory Standards reference method for antifungal susceptibility testing in yeasts was modified and applied to filamentous fungi. The inoculum was spectrophotometrically adjusted, and all tests were performed in buffered medium (RPMI 1640) at pH 7.0 with incubation at 35 degrees C for 72 h. MICs were read at 24, 48, and 72 h. Amphotericin B showed a minimum effect of inoculum size on MICs for all species with the exception of P. boydii (P < 0.05). A significant effect of inoculum size on MICs was observed with 5-fluorocytosine, for which there was an increase of more than 10-fold in MICs against all Aspergillus spp. between inoculum concentrations of 10(2) and 10(4) CFU/ml (P < 0.001). For itraconazole, the results showed a more species-dependent increase of MICs, most strikingly for R. arrhizus and P. boydii. Miconazole, which was tested only with P. boydii, did not demonstrate a significant effect of inoculum size on MICs. In summary, the effect of inoculum size on MICs for filamentous fungi was dependent upon the organism and antifungal compound tested. Thus, among antifungal compounds, itraconazole and 5-fluorocytosine demonstrated significant inoculum effects, while amphotericin B and miconazole showed comparatively minimum inoculum effects against pathogenic filamentous fungi. Moreover, among filamentous fungi, P. boydii and R. arrhizus exhibited the greatest inoculum effect.
Hybrid simulation methods for induction machine calculation reduction of simulation effort by coupling static FEA with transient FEA and analytic formulations (2017)

Induction machines for traction applications are operated at working points of high ferromagnetic saturation. Depending on the working point, a broad spectrum of harmonic frequencies appears in the magnetic flux density of induction machines. Detailed loss analysis therefore requires local and temporal highly resolved nonlinear field computation. This loss analysis could be performed in the post processing of nonlinear transient finite element simulations of the magnetic circuit. However, it takes a large number of transient simulation time steps to build up the rotor flux of the machine. In this paper we will discuss, analyze and compare hybrid simulation approaches that allow to decrease significantly the computational effort.
Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging (2000)

Diffusion magnetic resonance imaging provides an early marker of acute cerebral ischemic injury. Thrombolytic reversal of diffusion abnormalities has not previously been demonstrated in humans. Serial diffusion and perfusion imaging studies were acquired in patients experiencing acute hemispheric cerebral ischemia treated with intra-arterial thrombolytic therapy within 6 hours of symptom onset. Seven patients met inclusion criteria of prethrombolysis and postthrombolysis magnetic resonance studies, presence of large artery anterior circulation occlusion at angiography, and achievement of vessel recanalization. Mean diffusion-weighted imaging lesion volume at baseline was 23 cm3 (95% confidence interval [95% CI], 8-38 cm3) and decreased to 10 cm3 (95% CI, 3-17 cm3) 2.5 to 9.5 hours after thrombolysis. Mean apparent diffusion coefficient lesion volume decreased from 9 cm3 (95% CI, 2-16 cm3) at baseline to 1 cm3 (95% CI, 0.4-2 cm3) early after thrombolysis. A secondary increase in diffusion volumes was seen in 3 of 6 patients at day 7. In all 4 patients in whom perfusion imaging was obtained before and after treatment, complete resolution of the perfusion deficit was shown. Diffusion magnetic resonance signatures of early tissue ischemic injury can be reversed in humans by prompt thrombolytic vessel recanalization. The ischemic penumbra includes not only the region of diffusion/perfusion mismatch, but also portions of the region of initial diffusion abnormality.
Prototyping a hybrid main memory using a virtual machine monitor (2008)

We use a novel virtualization-based approach for computer architecture performance analysis. We present a case study analyzing a hypothetical hybrid main memory, which consists of a first-level DRAM augmented by a 10-100x slower second-level memory. This architecture is motivated by the recent emergence of lower-cost, higher-density, and lower-power alternative memory technologies. To model such a system, we customize a virtual machine monitor (VMM) with delay-simulation and instrumentation code. Benchmarks representing server, technical computing, and desktop productivity workloads are evaluated in virtual machines (VMs). Relative to baseline all-DRAM systems, these workloads experience widely varying performance degradation when run on hybrid main memory systems which have significant amounts of second-level memory.
3D-2D ultrasound feature-based registration for navigated prostate biopsy: A feasibility study (2016)

The aim of this paper is to describe a 3D-2D ultrasound feature-based registration method for navigated prostate biopsy and its first results obtained on patient data. A system combining a low-cost tracking system and a 3D-2D registration algorithm was designed. The proposed 3D-2D registration method combines geometric and image-based distances. After extracting features from ultrasound images, 3D and 2D features within a defined distance are matched using an intensity-based function. The results are encouraging and show acceptable errors with simulated transforms applied on ultrasound volumes from real patients.
Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. (1993)

We have determined the patterns of mRNA and protein expression of 7 protein kinase C (PKC) isozymes in NIH 3T3 cells. Only PKC-alpha is expressed abundantly in NIH 3T3 cells; endogenous levels of the other 6 PKC isozymes are low or undetectable. We have overexpressed PKC-delta and -epsilon in these cells to observe activation/translocation of these two isozymes and the biological consequences of overexpression. Both PKC-delta and -epsilon, but not PKC-alpha, are partially associated with the insoluble fraction even in the absence of phorbol 12-myristate 13-acetate (PMA). Upon PMA stimulation, both PKC-delta and -epsilon translocate to the insoluble fraction of cell homogenates, as can be observed with the endogenous PKC-alpha. Overexpression of PKC-delta induces significant changes in morphology and causes the cells to grow more slowly and to a decreased cell density in confluent cultures. These changes are accentuated by treatment with PMA. Overexpression of PKC-epsilon does not lead to morphological changes, but causes increased growth rates and higher cell densities in monolayers. None of the PKC-delta overexpressers grow in soft agar with or without PMA, but all the cell lines that overexpress PKC-epsilon grow in soft agar in the absence of PMA, but not in its presence. NIH 3T3 cells that overexpress PKC-epsilon also form tumors in nude mice with 100% incidence. This indicates that high expression of PKC-epsilon contributes to neoplastic transformation.
Retrospective Analysis of Concurrent Chemoradiation with the Combination of Bleomycin, Ifosfamide and Cisplatin (BIP) for Uterine Cervical Cancer (2004)

Combination chemotherapy consisting of bleomycin, ifosfamide, and ciplatin (BIP) is recognized as one of the most effective chemotherapies for uterine cervical cancer. However, there have been no reports that evaluate concurrent use of radiation with BIP. The objective of this study was to evaluate the toxicity and response of the combination of BIP concurrent with radiation in patients with squamous cell carcinoma of the uterine cervix. Eligibility criteria included patients who underwent radical hysterectomy (Type III hysterectomy) as a primary treatment and revealed lymph node metastases or deep myometrial invasion (stage IB and IIA) and patients who were previously untreated (stage IIB-IV). All of the patients had biopsy-proven squamous cell carcinoma of the uterine cervix. The patients received three courses of BIP chemoradiation, and the response and toxicity were evaluated. From January 2000 to December 2003, 30 patients met study eligibility criteria. All but three patients completed 3 courses of planned chemotherapy. The frequency of severe (grade 3 and 4) toxicity was as follows: anemia, 46.7%; neutrocytopenia, 73.3%; thrombocytopenia, 16.7%; and nausea and vomiting, 23.3%. Among 30 patients, 22 cases were evaluated for response. Complete response was achieved in 16 (72.7%) of patients, with a response rate of 90.9%. In conclusion, BIP chemoradiation seems to be superior to previously reported chemoradiation regimens, and has a potential as an optimal combination chemotherapy concurrent with radiation.
Proton pumping and the internal pH of yeast cells, measured with pyranine introduced by electroporation (1995)

The internal pH of yeast cells was determined by measuring the fluorescence changes of pyranine (8-hydroxy-1,3,6-pyrene-trisulfonic acid), which was introduced into the cells by electroporation. This may be a suitable procedure for the following reasons. (i) Only minor changes in the physiological status of the cells seemed to be produced. (ii) The dye did not seem to leak at a significant rate from the cells. (iii) Different incubation conditions produced large fluorescence changes in the dye, which in general agree with present knowledge of the proton movements of the yeast cell under different conditions. (iv) Pyranine introduced by electroporation seemed to be located in the cytoplasm and to avoid the vacuole, and therefore it probably measured actual cytoplasmic pH. (v) Correction factors to obtain a more precise estimation of the internal pH are not difficult to apply, and the procedure may be useful for other yeasts and microorganisms, as well as for the introduction of other substances into cells. Values for the cytoplasmic pHs of yeast cells that were higher than those reported previously were obtained, probably because this fluorescent indicator did not seem to penetrate into the cell vacuole.
Algorithms for spectral color stimulus reconstruction with a seven-channel multispectral camera (2004)

A mobile seven-channel multispectral camera with optical bandpass filters has been realized. The filters are arranged in a filter wheel rotating between lens and greyscale sensor (CCD). The time required for a complete multispectral exposure was brought down to less than one second. The main part of this paper deals with the algorithms applied to reconstruct spectral color stimuli information from the seven sampling values of the camera. Different methods have been simulated and tested. Results are presented. As the camera is handy enough to offer mobile applications, the illuminant problem for the use under varying light conditions has been studied. Finally, a solution for geometric inter-channel distortions due to glass filters within the optical path inside the camera is pointed out.
Site-specific Incorporation of Keto Amino Acids into Functional G Protein-coupled Receptors Using Unnatural Amino Acid Mutagenesis (2007)

G protein-coupled receptors (GPCRs) are ubiquitous heptahelical transmembrane proteins involved in a wide variety of signaling pathways. The work described here on application of unnatural amino acid mutagenesis to two GPCRs, the chemokine receptor CCR5 (a major co-receptor for the human immunodeficiency virus) and rhodopsin (the visual photoreceptor), adds a new dimension to studies of GPCRs. We incorporated the unnatural amino acids p-acetyl-L-phenylalanine (Acp) and p-benzoyl-L-phenylalanine (Bzp) into CCR5 at high efficiency in mammalian cells to produce functional receptors harboring reactive keto groups at three specific positions. We obtained functional mutant CCR5, at levels up to approximately 50% of wild type as judged by immunoblotting, cell surface expression, and ligand-dependent calcium flux. Rhodopsin containing Acp at three different sites was also purified in high yield (0.5-2 microg/10(7) cells) and reacted with fluorescein hydrazide in vitro to produce fluorescently labeled rhodopsin. The incorporation of reactive keto groups such as Acp or Bzp into GPCRs allows their reaction with different reagents to introduce a variety of spectroscopic and other probes. Bzp also provides the possibility of photo-cross-linking to identify precise sites of protein-protein interactions, including GPCR binding to G proteins and arrestins, and for understanding the molecular basis of ligand recognition by chemokine receptors.
Nucleophilically Assisted Deacylation in Sodium Dodecanoate and Dodecyl Sulfate Micelles. Quantitative Evidence on Premicellar Complexes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleophilically Assisted Deacylation in Sodium Dodecanoate and Dodecyl Sulfate Micelles. Quantitative Evidence on Premicellar ComplexesDilma M. O. Marconi, Vera L. A. Frescura, Dino Zanette, Faruk Nome, and Clifford A. BuntonCite this: J. Phys. Chem. 1994, 98, 47, 12415–12419Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/j100098a042https://doi.org/10.1021/j100098a042research-articleACS PublicationsRequest reuse permissionsArticle Views101Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Single-wavelength 40 Gbit/s soliton field transmissionexperiment over 400 km of installed fibre (1999)

40 Gbit/s soliton transmission over 400 km (57 km amplifier spacing) of installed lines without in-line control has been achieved. The maximum transmission penalties for parallel polarised and polarisation division multiplexed soliton transmission were ~4 and 1 dB, respectively. The transmission distance is the longest ever reported for a field trial with a single wavelength bit rate &gt; 20 Gbit/s for any optical transmission format. The polarisation mode dispersion was numerically found to completely dominate the system performance.
Correlation between active layer thickness and ambient gas stability in IGZO thin-film transistors (2016)

Decreasing the active layer thickness has been recently reported as an alternative way to achieve fully depleted oxide thin-film transistors for the realization of low-voltage operations. However, the correlation between the active layer thickness and device resistivity to environmental changes is still unclear, which is important for the optimized design of oxide thin-film transistors. In this work, the ambient gas stability of IGZO thin-film transistors is found to be strongly correlated to the IGZO thickness. The TFT with the thinnest IGZO layer shows the highest intrinsic electron mobility in a vacuum, which is greatly reduced after exposure to O2/air. The device with a thick IGZO layer shows similar electron mobility in O2/air, whereas the mobility variation measured in the vacuum is absent. The thickness dependent ambient gas stability is attributed to a high-mobility region in the IGZO surface vicinity with less sputtering-induced damage, which will become electron depleted in O2/air due to the electron transfer to adsorbed gas molecules. The O2 adsorption and deduced IGZO surface band bending is demonstrated by the ambient-pressure x-ray photoemission spectroscopy results.