gebhart/patrepeval huggingface dataset:
Cellular and molecular basis of barrier function in oral epithelium. (1991)

The use of the oral mucosa for drug delivery and the erroneous belief that it is a nonkeratinized tissue have given rise to the suggestion that the oral mucosa is a permeable tissue. Such an assumption is not supported by studies which indicate that permeability differs significantly in different oral regions, depending on the pattern of epithelial differentiation. Keratinized regions such as hard palate and gingiva have a permeability which is significantly less than nonkeratinized regions like buccal mucosa and floor of mouth. Nevertheless, all oral regions are more permeable than skin. Associated with these differences in permeability are differences in the type and amount of intercellular lipid; areas of keratinized tissue contain predominantly neutral lipids (ceramides) apparently derived from lamellate membrane-coating granules. In nonkeratinized areas, the lipids consist of as yet uncharacterized glycosyl ceramides that appear to be derived from membrane-coating granules that differ morphologically from those present in nonkeratinized tissue.
ChemInform Abstract: Transformation of 5,6,7,8‐Tetrahydro‐2H‐1‐benzopyran‐2,8‐diones with Hydrazines and Hydrazoic Acid: Synthesis of 8‐Hydrazono‐5,6,7,8‐tetrahydro‐2‐oxo‐2H‐1‐benzopyrans, Pyrano[2,3‐c]azepines, and Pyrido[2,3‐c]azepines. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Working Capital (2013)

For decades the cities of the developed world were seen as problem-beset relics from times of low mobility and slow communications. But now, their potential to sustain creativity, culture and innovation is perceived as crucial to success in a much more competitive global ecomony. The vital requirement to secure and sustain this success is argued to be the achievement of social cohesion.Working Capital provides a rigorous but accessible analysis of these key issues taking London as its test case. The book provides the first substantial analysis of key economic, social and structural issues that the new London administration needs to deal with. In a wider context, its critical assessment of the bases of the new urbanism and of the global city thesis will raise questions both about the adequacy of urban thinking and about the capacity of new institutions alone to resolve the fundamental problems faced by cities.
Environmental sound classification with convolutional neural networks (2015)

This paper evaluates the potential of convolutional neural networks in classifying short audio clips of environmental sounds. A deep model consisting of 2 convolutional layers with max-pooling and 2 fully connected layers is trained on a low level representation of audio data (segmented spectrograms) with deltas. The accuracy of the network is evaluated on 3 public datasets of environmental and urban recordings. The model outperforms baseline implementations relying on mel-frequency cepstral coefficients and achieves results comparable to other state-of-the-art approaches.
Higher Outcomes of Vasectomy Reversal in Men with the Same Female Partner as Before Vasectomy (2014)

Outcomes of clinical pregnancy and live birth rates are higher in men who undergo microsurgical vasectomy reversal with the same female partner. These outcomes may be related to a shorter interval from vasectomy, previous fertility and couple motivation.
Free Recall Memory Performance after Aneurysmal Subarachnoid Hemorrhage (2012)

Abstract Memory deficits for survivors of aneurysmal subarachnoid hemorrhage (SAH) are common, however, the nature of these deficits is not well understood. In this study, 24 patients with SAH and matched control participants were asked to study six lists containing words from four different categories. For half the lists, the categories were presented together (organized lists). For the remaining lists, the related words were presented randomly to maximize the use of executive processes such as strategy and organization (unorganized lists). Across adjoining lists, there was overlap in the types of categories given, done to promote intrusions. Compared to control participants, SAH patients recalled a similar number of words for the organized lists, but significantly fewer words for the unorganized lists. SAH patients also reported more intrusions than their matched counterparts. Separating patients into anterior communicating artery ruptures (ACoA) and ruptures in other regions, there was a recall deficit only for the unorganized list for those with ACoA ruptures and deficits across both list types for other rupture locations. These results suggest that memory impairment following SAH is likely driven by impairment in the executive components of memory, particularly for those with ACoA ruptures. Such findings may help direct future cognitive-therapeutic programs. ( JINS , 2012, 18 , 334–342)
Standardizing ASIC libraries in VHDL using VITAL: a tutorial (2002)

VITAL originated as an industry driven effort to standardize VHDL models for ASIC libraries. An IEEE version of VITAL is expected by the end of 1995. In this tutorial, after examining the goals behind the development of this standard, I shall discuss its central features using examples of VITAL-compliant models. Throughout, I shall concentrate on those aspects of VITAL which affect the development of ASIC models, and only touch on those which affect VHDL simulation development. Models using several VITAL-compliant styles are presented and discussed.
Accurate discrimination of the wake-sleep states of mice using non-invasive whole-body plethysmography (2017)

A major limitation in the study of sleep breathing disorders in mouse models of pathology is the need to combine whole-body plethysmography (WBP) to measure respiration with electroencephalography/electromyography (EEG/EMG) to discriminate wake-sleep states. However, murine wake-sleep states may be discriminated from breathing and body movements registered by the WBP signal alone. Our goal was to compare the EEG/EMG-based and the WBP-based scoring of wake-sleep states of mice, and provide formal guidelines for the latter. EEG, EMG, blood pressure and WBP signals were simultaneously recorded from 20 mice. Wake-sleep states were scored based either on EEG/EMG or on WBP signals and sleep-dependent respiratory and cardiovascular estimates were calculated. We found that the overall agreement between the 2 methods was 90%, with a high Cohen's Kappa index (0.82). The inter-rater agreement between 2 experts and between 1 expert and 1 naïve sleep investigators gave similar results. Sleep-dependent respiratory and cardiovascular estimates did not depend on the scoring method. We show that non-invasive discrimination of the wake-sleep states of mice based on visual inspection of the WBP signal is accurate, reliable and reproducible. This work may set the stage for non-invasive high-throughput experiments evaluating sleep and breathing patterns on mouse models of pathophysiology.
A hybrid solid electrolyte Li0.33La0.557TiO3/poly(acylonitrile) membrane infiltrated with a succinonitrile-based electrolyte for solid state lithium-ion batteries (2019)

An LLTO/PAN/SNE hybrid solid electrolyte membrane with high ionic conductivity and excellent compatibility with both LiFePO<sub>4</sub> cathode and metallic lithium anode.
cw 1→0 CO chemical laser: Optical pumping of CO (1976)

The first operation of a cw CO chemical laser delivering nearly 1 W of power oscillation on the 1→0 vibrational band is reported. Experimental results and operating details with respect to 1→0 emission are discussed. Optical pumping of CO by the CO chemical laser is also reported; optically pumped absorption has been measured up to the 6→5 band.
Pure red electroluminescence from a host material of binuclear gallium complex (2002)

By using a binuclear gallium complex, bis(salicylidene-o-aminophenolato)-bis(8quinolinoato)-bisgallium(III)[Ga2(saph)2q2], as the host material, organic light emitting diodes (OLEDs) with pure red emission were developed, which used a red fluorescent dye of 4-(dicyanomethylene)-2-t-butyle-6-(1,1,7,7-tetramethyljulolidyl-9-enyl)4H-pyran (DCJTB). Ga2(saph)2q2 proves to be of much better film-forming ability and a smaller energy gap than tris(8-quinolinolato)aluminum (Alq3). And the doped device with a configuration of indium tin oxide/N,N′-bis-(1-naphthl)-diphenyl-1,1′-biphenyl-4,4′-diamine/Ga2(saph)2q2: DCJTB (2 wt %)/Ga2(saph)2q2/Mg:Ag, exhibited a turn-on voltage as low as 2.2 V, and a pure red emission with Commission Internationale de l’Eclairage (CIE 1931) coordinates of (0.67, 0.33). The improved energy transfer gave a high current efficiency of 2.04 cd/A at 20 mA/cm2, which is about two times higher than that of the doped Alq3 device. This letter indicates that developing host materials is a promising way to achieve excellent red emission OLEDs.
Direct stochastic simulation ofCa2+motion inXenopuseggs (2005)

The release of important intracellular ions has been widely modeled using two approaches, namely, (1) Fickian diffusion, in which sometimes tensorial diffusion coefficients are used to fit observed temporally varying concentrations of calcium, and (2) cellular automata, which produce a set of localized finite difference equations that result in complex global behavior. Here, we take a different approach, employing some assumed, a priori, distribution of ion-binding proteins in the cell, and some assumed biochemical capture and release characteristics to explain ionic motion, and ultimately, distribution. We study several scenarios for ion distribution, based on differences in binder action and distribution. The numbers and strengths of ion binders, spatial variation in inositol 1,4,5-triphosphate concentration, together with the escalating distribution of ionic diffusion speed, are found to be key factors leading to concavity in the Ca2+ wave shape. We also offer an explanation for geometrical effects on previously observed ion diffusion speeds in the cellular cortex of the Xenopus laevis egg during fertilization, based on an angle-of-view correction.
Research on bathymetry estimation by Worldview-2 based with the semi-analytical model (2015)

Abstract. South Sea Islands of China are far away from the mainland, the reefs takes more than 95% of south sea, and most reefs scatter over interested dispute sensitive area. Thus, the methods of obtaining the reefs bathymetry accurately are urgent to be developed. Common used method, including sonar, airborne laser and remote sensing estimation, are limited by the long distance, large area and sensitive location. Remote sensing data provides an effective way for bathymetry estimation without touching over large area, by the relationship between spectrum information and bathymetry. Aimed at the water quality of the south sea of China, our paper develops a bathymetry estimation method without measured water depth. Firstly the semi-analytical optimization model of the theoretical interpretation models has been studied based on the genetic algorithm to optimize the model. Meanwhile, OpenMP parallel computing algorithm has been introduced to greatly increase the speed of the semi-analytical optimization model. One island of south sea in China is selected as our study area, the measured water depth are used to evaluate the accuracy of bathymetry estimation from Worldview-2 multispectral images. The results show that: the semi-analytical optimization model based on genetic algorithm has good results in our study area;the accuracy of estimated bathymetry in the 0-20 meters shallow water area is accepted.Semi-analytical optimization model based on genetic algorithm solves the problem of the bathymetry estimation without water depth measurement. Generally, our paper provides a new bathymetry estimation method for the sensitive reefs far away from mainland.
Abstract 1956: ABCE1 regulates the translational profile of neuroblastoma to drive tumor progression (2017)

Abstract Neuroblastoma is the most common extracranial solid tumor in children. A key driver of high-risk neuroblastoma is the MYCN transcription factor which fuels neuroblastoma progression by enhancing metabolic processes including protein translation (1). ABCE1, a member of the ATP-binding cassette (ABC) superfamily of transporters, is a translation factor directly up-regulated by MYCN (2). It is thought to dissociate the 80S ribosome into free 40S and 60S subunits so they can re-initiate translation and provide the protein building blocks required for rapid cell growth and migration (3). High ABCE1 expression is associated with poor clinical outcome in neuroblastoma patients (2). Therefore, we hypothesized that ABCE1 suppression may inhibit the aggressiveness of neuroblastoma by disabling protein synthesis. To test this, we suppressed ABCE1 using siRNAs in MYCN-amplified neuroblastoma cell lines, SK-N-BE(2) and CHP-134, which resulted in severely impaired cell migration (P&amp;lt;0.001) and proliferation (P&amp;lt;0.005). In mice xenografted with SK-N-BE(2) cells, ABCE1 suppression delayed tumor growth (P=0.001) and metastasis (P&amp;lt;0.001). Mechanistically, when polyribosome analysis was used to monitor the impact of ABCE1 expression on protein translation in SK-N-BE(2) cells, loss of ABCE1 reduced the proportion of actively translating ribosomes (P&amp;lt;0.001), leading to lower global protein synthesis (P=0.018). This is the first report of ABCE1 acting as pro-tumorigenic factor in neuroblastoma. Our data imply that targeting the translational machinery through ABCE1 may be an effective therapeutic approach for the treatment of MYC-driven cancers. 1. Boon, K., Caron, H. N., van Asperen, R., Valentijn, L., Hermus, M. C., van Sluis, P., Roobeek, I., Weis, I., Voûte, P.A., Schwab, M. &amp; Versteeg, R. (2001) EMBO J. 20, 1383-1393. 2. Porro, A., Haber, M., Diolaiti, D., Iraci, N., Henderson, M., Gherardi, S., Valli, E., Munoz, M.A., Xue, C., Flemming, C., Schwab, M., Wong, J.H., Marshall, G.M., Della Valle, G., Norris, M.D. &amp; Perini, G. (2010) J. Biol. Chem. 285, 19532-19543. 3. Pisarev, A.V., Skabkin, M.A., Pisareva, V.P., Skabkina, O.V., Rakotondrafara, A.M., Hentze, M.W., Hellen C.U. &amp; Pestova, T.V. (2010). Mol. Cell, 37, 196-210. Citation Format: Jixuan Gao, Klaartje Somers, Katherine M. Hannan, Jamie I. Fletcher, Bing Liu, Ross D. Hannan, Richard B. Pearson, Michelle Haber, Murray D. Norris, Michelle J. Henderson. ABCE1 regulates the translational profile of neuroblastoma to drive tumor progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1956. doi:10.1158/1538-7445.AM2017-1956
Combined Therapy of Dietary Fish Oil and Stearoyl-CoA Desaturase 1 Inhibition Prevents the Metabolic Syndrome and Atherosclerosis (2009)

SCD1 ASO treatment in conjunction with dietary fish oil supplementation is an effective combination therapy to comprehensively combat the metabolic syndrome and atherosclerosis in mice.
Classification of modes in multi-moded photonic crystal microcavities (2004)

Resonant modes in multi-moded photonic crystal cavities are experimentally characterized and we obtain excellent agreement between these observations and predictions based on a combination of finite-difference time-domain simulations, group theory, and Green's functions
ChemInform Abstract: Formation of 5‐Phenyl‐1‐vinyl‐1H‐pyrrole‐2‐carbonitrile in the Vinylation of 5‐Phenyl‐1‐vinyl‐1H‐pyrrole‐2‐carbaldehyde Oxime with Acetylene. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nonlinear ultrasonic propagation in biological media. (1982)

The nonlinearity parameter B/A for several biological materials was determined by measuring the amplitude of the second harmonic pressure as a function of distance from the source and the amplitude of the fundamental at the source. The B/A values for bovine serum albumin and haemoglobin solutions were found to increase approximately linearly with solution concentration. Blood and homogenized liver exhibit a B/A value similar to a haemoglobin solution of the same dry weight, but whole liver has a greater B/A value.
Catalysts for the Oxygen Reduction from Heat-Treated Iron(III) Tetramethoxyphenylporphyrin Chloride:  Structure and Stability of Active Sites (2003)

Structure and stability of an iron-based catalyst for the oxygen reduction reaction, prepared by heat treatment of carbon-supported iron(III) tetramethoxyphenylporphyrin chloride (FeTMPP−Cl), were investigated. The oxygen reduction in acid electrolyte was examined with the rotating (ring) disk electrode. The measurements confirmed that H2O2 is generated as a byproduct of the oxygen reduction. The structural elucidation of the catalyst showed that the porphyrin decomposes during heat treatment. Nitrogen atoms of the heat-treated porphyrin become bonded at the edge of graphene layers as pyridine- and pyrrole-type nitrogen. Two Fe3+ components as well as metallic, carbidic and oxidic iron were detected by Mössbauer spectroscopy. An electrochemical longevity test and two degradation experiments with sulfuric acid and H2O2 showed that H2O2 causes the degradation of active sites. A 6-fold coordinated Fe3+ compound seems to be responsible for the catalytic activity. Only 8% of the primary iron content is present in the active iron component.
A cell cycle-responsive transcriptional control element and a negative control element in the gene encoding DNA polymerase alpha in Saccharomyces cerevisiae. (1991)

Transcription of the POL1 gene of Saccharomyces cerevisiae, which encodes DNA polymerase alpha, the DNA polymerase required for the initiation of DNA replication, has previously been shown to be cell cycle regulated. To understand how the POL1 gene senses cell cycle position, we have investigated the cis-acting elements that respond to the factors that govern cell cycle progression. In this report we demonstrate that a region of 54 nucleotides containing the repeated element ACGCGT, which conforms to an Mlu I restriction endonuclease recognition site, contains all information necessary for transcriptional activation and cell cycle responsiveness. Although oligonucleotides lacking either one or both of the repeated Mlu I sites can function as an upstream activating sequence, the presence of at least one Mlu I site stimulates expression and, moreover, is absolutely essential for cell cycle regulation. A synthetic oligonucleotide corresponding to a 19-base-pair sequence in the POL1 promoter containing one Mlu I site can function as an autonomous cell cycle-responsive upstream element (upstream activation sequence) with temporal regulation indistinguishable from that previously described for the POL1 gene. Thus, the Mlu I site is an essential part of a cis-acting element responsible for the observed periodic activation. This sequence differs from previously defined cell cycle-responsive transcriptional control elements in the yeast HO endonuclease and histone genes. We also present evidence for a negative regulatory element in the 5' flanking region of the Mlu I upstream activation sequence.
Comments to young surgeons concerning laparoscopic spleen-preserving D2 lymph node dissection for advanced gastric cancer on the upper body. (2014)

Qualified radical gastrectomy with lymph node dissection is very important to the prognosis of patients with gastric cancer. Now D2 lymph node dissection is standard procedure for gastric cancer surgery, and spleen hilar lymph node dissection is mandatory for gastric cancer in upper body. Because the anatomy of vessels in this area is very complicated, D2 lymph node dissection is technical challenging not only for open gastrectomy but also for laparoscopic one. Adapting a new technique is important to all surgeons, but we surgeons should always consider a patient's safety as the most important factor during surgery and that efforts should be based on scientific rationale with oncologic principles. I hope that the recent report by Huang et al. about laparoscopic spleen preserving hilar lymph node dissection would be helpful to young surgeons who will perform laparoscpic total gastrectomy for gastric cancer.
Enzyme activity and structural features of three single-domain phloem cyclophilins from Brassica napus (2019)

Cyclophilins (CYPs) are a group of ubiquitous prolyl cis/trans isomerases (PPIases). It was shown that plants possess the most diverse CYP families and that these are abundant in the phloem long-distance translocation stream. Since phloem exudate showed PPIase activity, three single-domain CYPs that occur in phloem samples from Brassica napus were characterised on functional and structural levels. It could be shown that they exhibit isomerase activity and that this activity is controlled by a redox regulation mechanism, which has been postulated for divergent CYPs. The structure determination by small-angle X-ray scattering experiments revealed a conserved globular shape. In addition, the high-resolution crystal structure of BnCYP19-1 was resolved and refined to 2.0 Å resolution, and the active sites of related CYPs as well as substrate binding were modelled. The obtained data and results support the hypothesis that single domain phloem CYPs are active phloem PPIases that may function as chaperones.
Role of DNase in recovery of plasmid DNA from Clostridium perfringens (1984)

Recovery of plasmid DNA from Clostridium perfringens 10543A and 3626B cleared lysates was significantly improved by the addition of 0.2% (vol/vol) diethylpyrocarbonate (DEP) before protoplast disruption in the cleared lysate protocol. Three previously undetected, large-molecular-mass plasmids (45.2, 51.9, and 68.2 megadaltons) were isolated from modified DEP-treated cleared lysates of C. perfringens 3626B. Two plasmids (9.4 and 30 megadaltons) were recovered from C. perfringens 10543A modified DEP-treated cleared lysates which previously required dye-buoyant density gradient centrifugation for visualization on agarose gels. Unsuccessful attempts to isolate plasmid DNA from Brij 58 cleared lysates of extracellular DNase-negative mutants of C. perfringens suggested the deleterious DNase activity was not extracellular. Cellular localization studies indicated that the cell wall-compartmentalized cell fraction contained 72.2% of the total DNase activity, whereas the extracellular and intracellular fractions demonstrated much less (26.8 and 1.0%, respectively). Cleared lysates prepared with DEP demonstrated much less DNase activity than cleared lysates prepared without DEP. The variable and irreproducible recovery of plasmid DNA from C. perfringens cleared lysates was attributed to cell wall-compartmentalized DNase.
ChemInform Abstract: [Ni(NHC)]‐Catalyzed Cycloaddition of Diynes and Tropone: Apparent Enone Cycloaddition Involving an 8π Insertion. (2015)

Abstract The reaction tolerates a broad variety of functional groups and proceeds with excellent regioselectivity in most cases.