gebhart/patrepeval huggingface dataset:
SET kinetics of electrochemical metallization cells: influence of counter-electrodes in SiO2/Ag based systems (2017)

The counter-electrode material in resistively switching electrochemical metallization cells (ECMs) is a crucial factor influencing the nucleation of conductive filaments, the equilibrium electrode potentials, and kinetics in the devices, and hence the overall switching characteristics. Here, we demonstrate the influence of the counter-electrode (CE) material on the SET events and the importance of appropriate choice and combination of materials. The counter-electrode material influences the counter-electrode processes at the CE/insulator interface and consequently determines the metal ion concentration in the cells. We measured the switching kinetics for SiO<sub>2</sub>/Ag based ECM cells using different counter-electrode materials with different electrocatalytic activities towards water reduction, namely platinum, ruthenium, and iridium oxide, as well as titanium nitride and tantalum. The experimental results are fitted using a physical simulation model and are analysed for the limiting factors for fast SET kinetics.
Improving the Android development lifecycle with the VALERA record-and-replay approach (2015)

As smartphones become more and more popular, developers are switching their focus from traditional desktop programs to mobile apps. Recording and replaying the execution of mobile apps is useful in development tasks, from reproducing bugs to profiling and testing. However, achieving effective record-and-replay on mobile devices is a balancing act between accuracy and overhead. Prior record-and-replay approaches have focused on replaying low-level instructions, which impose significant overhead. We propose a novel, stream-oriented record-and-replay approach which achieves high-accuracy and low-overhead by aiming at a sweet spot: recording and replaying sensor and network input, event schedules, and inter-app communication via intents. To demonstrate the versatility of our approach, we have constructed a tool named that supports record-and-replay on the Android platform. Through an evaluation on 50 popular Android apps, we show that: 's replay fidelity far exceeds current record-and-replay approaches for Android; 's low-overhead allows it to replay high-throughput, timing-sensitive apps; With the ability to deterministically replay event schedule, can help to reproduce and verify event-driven races.
Degradation of carrot (Daucus carota) fibres with cell wall polysaccharide-degrading enzymes (1989)

36 ref.
461 Intracranial Tumors Hijack the Meningeal Venolymphatic Network Through VEGFR-2 Signaling (2023)

INTRODUCTION: Glioblastoma and other intracranial neoplasms have been associated with breakdown of the blood brain barrier. Other protective CNS barriers have sparsely been studied in brain tumors. Here, we identify the ability of intracranial neoplasms to hijack the meningeal venolymphatic network, which is driven through VEGFR-2/VEGF-A signaling. METHODS: C57BL/6J mice were stereotactically injected with syngeneic SB28 (glioblastoma) cell lines. Mice were treated with either isotype control or a VEGFR-2 inhibitor. Two-photon microscopy was used to visualize vascular cytoarchitecture and dynamics in vivo. Meningeal whole mounts, brains and spleens were also collected and analyzed by confocal microscopy and high parameter flow cytometry. Similar experiments were conducted with a PECAM-1 inhibitor to assess the role of endothelial cell crosstalk in venolymphatic expansion. Human dura mater from glioblastoma patients underwent multiplex immunohistochemistry to confirm the translatability of our findings. RESULTS: Our imaging studies revealed that glioblastomas can generate an extensive de novo network of meningeal blood vessels and lymphatics both in mice and humans. Lymphatic vessels were often observed developing in parallel to the newly formed vasculature. Intravital two-photon microscopy further revealed that the peritumoral vascular bed in the meninges of mice was leaky, dysfunctional, and generated a hypoxic microenvironment. Importantly, inhibition of VEGFR signaling impeded formation of this faulty venolymphatic network, which slowed tumor growth, reduced peritumoral hypoxia, enhanced immune infiltration, and increased survival. PECAM-1 (CD31) inhibition had a similar effect on the tumor microenvironment, suggesting that endothelial cell crosstalk is required for glioblastomas to optimally invade the meninges. CONCLUSIONS: Our results demonstrate that glioblastomas can invade the meninges and hijack the venolymphatic network through VEGFR-2 and PECAM-1 signaling. While VEGFR-2 is associated with angiogenesis, our data suggest that it may also have an important role in regulating the simultaneous development of de novo meningeal venous and lymphatic drainage during glioblastoma.
Pseudopotential methods for superlattices: Applications to mid-infrared semiconductor lasers (1999)

Many mid-infrared semiconductor laser sources are now being developed with superlattice active regions. Calculations of gain, index of refraction, and intervalence subband absorption for these laser materials require accurate subband energies, wave functions, and radiative matrix elements. We have recently begun using a solution method based on the empirical pseudopotential method (EPM). This method shows particular strength in analyzing structures with short periods or thin layers, for which the standard method, based on k⋅p perturbation theory and the envelope function approximation, may be problematical. We will describe the EPM applied to bulk solids and then demonstrate our direct generalization of the method for applications to superlattice structures. Calculations for recently developed mid-infrared semiconductor lasers using type-II superlattice active regions will be used to illustrate the method.
The effect of cytokines on the in-vitro erythropoietin bioassay (2008)

The effects of various concentrations of granulocyte macrophage colony stimulating factor (GM-CSF), gamma interferon (gamma IFN) and interleukins 1 alpha (IL-1 alpha), 1 beta (IL-1 beta) and 3 (IL-3) on the anaemic mouse spleen cell bioassay for erythropoietin (EPO) were investigated. Addition of IL-3 and GM-CSF at various concentrations had no effect on EPO stimulated 3H thymidine incorporation. However the addition of IL-1 alpha, IL1-beta and gamma IFN (3.3 x 10(-8) gl-1) caused a significant (P < 0.01) inhibition of EPO stimulated thymidine incorporation. This suggests that the EPO bioassay may be influenced by variable levels of some inflammatory cytokines in serum. Previous studies have shown that the bioassay is influenced by serum transferrin levels and thus serum immunoassays remain the technique of choice for specific estimates of EPO. Since EPO bioassays are not specific, they should be reserved for situations in which an estimate of the total erythropoietic activity of serum is required.
A Randomized, Double‐Blind, Placebo‐Controlled, First‐Time‐in‐Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of GSK3389404 in Healthy Subjects (2019)

GSK3389404 is a liver-targeted antisense oligonucleotide that inhibits synthesis of hepatitis B surface antigen and all other hepatitis B virus proteins. This first-in-human, randomized, double-blind, phase 1 study assessed the safety and pharmacokinetics of GSK3389404 administered subcutaneously (SC) in healthy subjects. Four single ascending-dose cohorts (10 mg, 30 mg, 60 mg, and 120 mg) and 3 multiple ascending-dose cohorts (30 mg, 60 mg, and 120 mg once weekly for 4 weeks) each comprised 6 subjects randomized to GSK3389404 and 2 subjects randomized to placebo. There were no serious adverse events (AEs) or withdrawals due to AEs. The safety profile did not worsen with repeated dosing. The most frequent treatment-related AEs were injection site reactions (19.0% [n = 8/42], frequency unrelated to dose levels); all were mild (Grade 1) and resolved without dose modification or discontinuation. GSK3389404 administered subcutaneously was readily absorbed with a time to maximum plasma concentration (T<sub>max</sub> ) of 1-4 hours and an elimination half-life of 3-6 hours in plasma. Plasma area under the concentration-time curve (AUC) and maximum observed concentration (C<sub>max</sub> ) were dose-proportional. Dose-normalized plasma AUC from time 0 to infinity averaged 69.9 ng·h/(mL·mg dose) across cohorts, and C<sub>max</sub> 9.5 ng/(mL·mg dose). Pharmacokinetic profiles and parameters were comparable between single and multiple dosing. No accumulation was observed with once-weekly dosing. The metabolite was undetectable in urine and plasma. In the pooled urine, GSK3389404 was estimated to account for <0.1% of the total dose. In summary, GSK3389404 dosing has been tested up to 120 mg for 4 weeks with an acceptable safety and pharmacokinetic profile, supporting further clinical investigation in patients with chronic hepatitis B.
Single fiber temperature probe configuration using anti-Stokes luminescence from Cr:GdAlO3 (2018)

Single-photon excitation of anti-Stokes-shifted emission from a thermographic phosphor allows operation of a luminescence decay-based single fiber temperature probe with negligible interference from background fiber-generated Raman scattering. While single fiber probe configurations for luminescence-based fiber optic thermometers offer advantages of simple design, compactness, and superior emission light collection efficiency, their effective use has been limited by interference from Raman scattering in the fiber probe and excitation delivery fiber that produces distortion of the luminescence decay that follows the excitation pulse. The near elimination of interference by background fiber-generated Raman scattering was demonstrated by incorporating a Cr-doped GdAlO3 (Cr:GdAlO3) thermographic phosphor as the sensing element at the end of a single fiber luminescence decay-based thermometer and detecting anti-Stokes-shifted luminescence centered at 542 or 593 nm produced by 695 nm excitation. Measurements were performed using both silica (up to 1150 °C) and single-crystal YAG (up to 1200 °C) fiber-based thermometers. Selection of emission detection centered at 542 nm greatly benefited the YAG fiber probe measurements by practically eliminating detection of otherwise significant luminescence from Cr3+ impurities in the YAG fiber. For both the silica and YAG fiber probes, the relative benefit of adopting single-photon excitation of anti-Stokes-shifted luminescence was evaluated by comparison with results obtained by conventional 532 nm excitation of Stokes-shifted luminescence.
An Efficient Planar Feature Fitting Method Using Point Cloud Simplification and Threshold-Independent BaySAC (2016)

Three-dimensional laser scanning can acquire point cloud data with high spatial resolution. However, for practical applications, such as point cloud fitting and 3-D reconstruction, there is usually significant data redundancy, which reduces the operational efficiency. In this letter, we propose a fast point cloud fitting algorithm that uses point cloud simplification to preserve feature boundaries and threshold-independent Bayesian sampling consensus (BaySAC) to fit planar features. We first extract the point features, such as corner points and contour points, using a smoothing analysis of the vicinities of scattered points and an angle analysis of vectors based on search points and their adjacent points. Then, keeping all the feature points, we thin the nonfeature points by constructing a cube grid. Finally, based on the least median squares and the BaySAC algorithm, we propose a robust nonthreshold-dependent method to perform the rapid fitting of planar features in the point cloud after thinning. We used three sets of point cloud data acquired using a 3-D laser scanner to verify the accuracy and efficiency of the planar feature fitting method. The experimental results indicate that the method can extract finer planar features and has significantly better accuracy and computational efficiency than the classical random sample consensus algorithm for the fitting of planar features without using a threshold.
Human Mob Proteins Regulate the NDR1 and NDR2 Serine-Threonine Kinases (2004)

Human NDR1 (nuclear Dbf2-related) is a widely expressed nuclear serine-threonine kinase that has been implicated in cell proliferation and/or tumor progression. Here we present molecular characterization of the human NDR2 serine-threonine kinase, which shares approximately 87% sequence identity with NDR1. NDR2 is expressed in most human tissues with the highest expression in the thymus. In contrast to NDR1, NDR2 is excluded from the nucleus and exhibits a punctate cytoplasmic distribution. The differential localization of NDR1 and NDR2 suggests that each kinase may serve distinct functions. Thus, to identify proteins that interact with NDR1 or NDR2, epitope-tagged kinases were immunoprecipitated from Jurkat T-cells. Two uncharacterized proteins that are homologous to the Saccharomyces cerevisiae kinase regulators Mob1 and Mob2 were identified. We demonstrate that NDR1 and NDR2 partially colocalize with human Mob2 in HeLa cells and confirm the NDR-Mob interactions in cell extracts. Interestingly, NDR1 and NDR2 form stable complexes with Mob2, and this association dramatically stimulates NDR1 and NDR2 catalytic activity. In summary, this work identifies a unique class of human kinase-activating subunits that may be functionally analagous to cyclins.
Trust visualization for object management in Internet of Things (2016)

This paper proposed trust visualization for object management in Internet of Things environment. Based on the proposed system, trust based object visualization methods are introduced. Actual implementation shows that graph-based trust visualization helps user perceptions to handle various related objects.
ChemInform Abstract: N‐(4‐Aryl‐but‐3‐ynyl)‐4‐phenyl‐1,2,3,6‐tetrahydropyridines as Potential Antipsychotic Agents: Synthesis and Structure‐Activity Relationships. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Traffic Safety Benefit of A Lane Departure Warning System (2018)

Lane departures can have serious consequences when resulting in run-off-road and oncoming crashes and effective countermeasures are of utmost importance. The objective of this study was to evaluate the real-world crash avoidance effectiveness of a Lane Departure Warning (LDW) crash avoidance system, introduced as optional mounted equipment in Volvo car models in 2008. Situations addressed by the LDW system—single-vehicle run-off-road and oncoming crashes in which the driver unintentionally leaves the lane without loss of control—were identified in insurance claims data. To evaluate the crash avoidance effect, crash rates were calculated and compared for vehicles with and without LDW. The rate of run-offroad crashes without traction loss was reduced by 30% if the vehicle had LDW (RD = 0.20 , 80% CI [0.03, 0.37]). There were not enough oncoming crashes to evaluate them statistically. The analysis revealed that the system has a large crash avoidance effect in real-world traffic; and the findings are promising for further refinement of these technologies, which target the avoidance of run-off-road and oncoming crashes.
The Blink Reflex in Chronic Tension-Type Headache, Migraine, and Cervicogenic Headache (1994)

R1 and R2 blink reflex latencies were investigated blind in 10 patients with cervicogenic headache, 11 patients with chronic tension-type headache, 11 patients with migraine, and 9 headache-free controls. There were no R1 or R2 latency differences between the four groups. The latency of R1 increased significantly with headache duration in tension-type headache patients. Shorter R1 latencies were found on the symptomatic side than on the non-symptomatic side in cervicogenic headache patients. The results suggest that a state of hyperactivity may be present in the ipsilateral trigeminal nucleus in cervicogenic headache. Hypoactivity, however, may develop over time in tension-type headache.
Direct Numerical Integral Method to Determine Periodic Solutions of Nonlinear Systems. Equations of Motion with Discontinuous Functions. (1993)

The direct numerical integral method (D.N.I.) which is a kind of shooting method, is presented for determining the periodic solutions of nonlinear systems with discontinuous characteristics. The present method is applied to a system with Coulomb's frictions, a system with bilinear stiffness and damping, and a system with preloaded compliance. By comparing the results of this method and the analytical method, it is found that this method yields very accurate results. In the system with Coulomb's frictions, many kinds of periodic solutions, i.e., slip, stick-slip and lockup solutions are obtained. In the other two systems, superharmonic vibrations, subharmonic vibrations and ultra-subharmonic vibrations are obtained by the D.N.I. Moreover, Liapunov numbers are calculated by applying the algorithm to integrate the corresponding variational equation in the D.N.I.
AptaTRACE Elucidates RNA Sequence-Structure Motifs from Selection Trends in HT-SELEX Experiments (2016)

Aptamers, short RNA or DNA molecules that bind distinct targets with high affinity and specificity, can be identified using high-throughput systematic evolution of ligands by exponential enrichment (HT-SELEX), but scalable analytic tools for understanding sequence-function relationships from diverse HT-SELEX data are not available. Here we present AptaTRACE, a computational approach that leverages the experimental design of the HT-SELEX protocol, RNA secondary structure, and the potential presence of many secondary motifs to identify sequence-structure motifs that show a signature of selection. We apply AptaTRACE to identify nine motifs in C-C chemokine receptor type 7 targeted by aptamers in an in vitro cell-SELEX experiment. We experimentally validate two aptamers whose binding required both sequence and structural features. AptaTRACE can identify low-abundance motifs, and we show through simulations that, because of this, it could lower HT-SELEX cost and time by reducing the number of selection cycles required.
Deep Back-Projection Networks For Super-Resolution (2018)

The feed-forward architectures of recently proposed deep super-resolution networks learn representations of low-resolution inputs, and the non-linear mapping from those to high-resolution output. However, this approach does not fully address the mutual dependencies of low- and high-resolution images. We propose Deep Back-Projection Networks (DBPN), that exploit iterative up- and down-sampling layers, providing an error feedback mechanism for projection errors at each stage. We construct mutually-connected up- and down-sampling stages each of which represents different types of image degradation and high-resolution components. We show that extending this idea to allow concatenation of features across up- and down-sampling stages (Dense DBPN) allows us to reconstruct further improve super-resolution, yielding superior results and in particular establishing new state of the art results for large scaling factors such as 8x across multiple data sets.
Analysis of the Social Network in Serial Publications: representation in the Journal of Documentation (2009)

THE CONSTRUCTION OF MAPS OF SOCIAL NETWORKS IS SHOWN BASED IN THE JOURNAL OF DOCUMENTATION DURING THE PERIOD 1988-2005. THE ANALYSIS IS MADE BY: (I) AUTHORS THAT PRODUCE THE MOST WITHIN THE PUBLICATION, (II) AUTHORS WITH THE GREATEST CENTRALITY AND FREQUENCY IN QUOTES RECEIVED, (III) THE DOCUMENTS WITH THE HIGHEST NUMBER OF CITATIONS DURING THE PERIOD, AND (IV) THE JOURNALS MOST USED IN THE CONSUMPTION OF INFORMATION. 681 ENTRIES WERE RETRIEVED, WHICH WERE DIVIDED INTO 288 BOOK REVIEWS, 172 JOURNAL ARTICLES, 14 EDITORIAL MATERIALS, 12 ARTICLE REVIEWS, 9 REPRINTS AND 2 BIBLIOGRAPHIC ITEMS. THE BIBLIOGRAPHIC INFORMATION OF THE INSTITUTE FOR SCIENTIFIC INFORMATION (ISI) WAS THE ORIGINAL SOURCE FOR THE TREATMENT OF THE DATA AND THE PROGRAM USED WAS CITESPACE, WHICH AUTOMATICALLY GENERATES THE MAPS OF RELATIONSHIPS.
Experimental paraprotein neuropathy, demyelination by passive transfer of human IgM anti‐myelin‐associated glycoprotein (1993)

Circulating monoclonal IgM antibodies that react with myelin-associated glycoprotein are strongly associated with a specific type of human peripheral nerve demyelination. There has been great interest in this syndrome because, if the paraprotein could be shown to cause the demyelination, then it would be the first proven example of antibody-mediated demyelination in humans. Systemic transfusion of chickens with monoclonal IgM antibody isolated from one of these patients produced peripheral demyelination highly characteristic of the human syndrome. The experimental lesion consists of segmental demyelination and remyelination with minimal inflammation, specific antibody bound to myelin, and widening of the myelin lamellae. In the experimental model, antibody is concentrated in specialized myelin structures, the nodes of Ranvier, and Schmidt-Lanterman incisures, suggesting that myelin-associated glycoprotein may be the antigenic target in vivo. This demonstration that human myelin-associated glycoprotein antibodies cause demyelination in vivo is the final information needed to prove that this type of human demyelination is antibody mediated. This strengthens the proposition that nerve antibodies, present in other human neurological syndromes, may also cause disease.
Mosquito proboscis: An elegant biomicroelectromechanical system (2010)

The mouthparts of female mosquitoes have evolved to form a special proboscis, a natural biomicroelectromechanical system (BMEMS), which is used for painlessly penetrating human skin and sucking blood. Scanning electron microscope observations show that the mosquito proboscis consists of a small bundle of long, tapering, and feeding stylets that are collectively called the fascicle, and a large scaly outer lower lip called the labium. During blood feeding, only the fascicle penetrates into the skin while the labium buckles back to remain on the surface of the skin. Here, we measured the dynamic force of penetration of the fascicle into human skin to reveal the mechanical principle underlying the painless process of penetration. High-speed video observations of movements associated with insertion of the fascicle indicate that the "smart" mosquito does not directly pierce its victim's skin with the fascicle. Instead, it uses the two maxillas as variable frequency microsaws with nanosharp teeth to advance into the skin tissue. This elegant BMEMS enables the mosquito to insert its feeding fascicle into human skin using an exceedingly small force (average of 16.5 μN).