gebhart/patrepeval huggingface dataset:
Studies towards the Synthesis of Coprinolone, Δ6-Coprinolone, and Radulone A via an Anionic Electrocyclization Cascade (2008)

Studies towards the synthesis of coprinolone, Δ6-coprinolone, and radulone A, resulting in the synthesis of an advanced intermediate with the tricyclic protoilludane carbon skeleton, are described.
Effect of degenerate spherical harmonics and a method for automatic shimming of oblique slices (2001)

Several spherical harmonics degenerate on an oblique plane. Two-dimensional field mapping of an oblique slice causes ambiguity in determination of the degenerate spherical harmonics terms. Therefore, automatic shimming of oblique slices may lead to erroneous adjustment of shims corresponding to the degenerate spherical harmonics. In this paper an automatic slice shimming technique derived from the FASTMAP method (Gruetter R. Magn. Reson. Med. 1993; 29, 804-811) is proposed. This new method unequivocally determines and corrects all of the first- and the second-order shims for slices of arbitrary orientation.
The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice (2006)

The human neuromuscular disease myasthenia gravis (MG) is characterized by the generation of autoantibodies reactive with nicotinic acetylcholine receptors (AChR) that cause loss of AChR from the neuromuscular end-plate with resultant failure of neuromuscular transmission. A role for complement (C) in AChR loss has been suggested based upon morphological identification of C at the end-plate in MG and from the effects of C inhibition in murine models. Here we provide further evidence implicating C, and specifically the membrane attack complex (MAC), in a mouse model of MG. Mice deficient in the C regulators Daf1 and/or Cd59a were tested in the model. Wild-type mice were resistant to disease while mice deficient in Daf1 had mild disease symptoms with evidence of C activation and AChR loss at end-plates. Cd59a-deficient mice had very mild disease with some muscle inflammation and essentially undamaged end-plates. In contrast, mice deficient in both C regulators developed a severe paralytic disease with marked muscle inflammation and loss of end-plates. Inhibition of MAC assembly abrogated clinical disease in these double-deficient mice, demonstrating conclusively that MAC formation was driving pathology in the model. These findings provoke us to suggest that current anti-C therapeutics targeting MAC assembly will be beneficial in MG patients resistant to conventional therapies.
Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of arteether: pharmacokinetics, toxicity and antimalarial activity in mice (2014)

The nontoxic SNEDDS of arteether, improved arteether bioavailability and anti-malarial efficacy.
Characteristics of the Inhibitory Effect of Mitoxantrone and Pirarubicin on Lung Metastases of Colon Carcinoma 26 (1995)

This study was performed to evaluate the antimetastatic activity of antitumor agents against metastatic colon carcinoma 26 (Co 26Lu), and to investigate their mechanisms of action. Pirarubicin demonstrated the most striking antitumor activity in mice bearing intravenously injected Co 26Lu cells. Etoposide and mitoxantrone also showed marked antitumor activity. Pirarubicin and mitoxantrone also exerted remarkable inhibitory effect on spontaneous lung metastases from subcutaneously implanted Co 26Lu. Pirarubicin showed marked inhibition of both primary tumor growth and lung metastases. Mitoxantrone was effective in preventing lung metastases even at doses that did not exhibit an antitumor effect on the primary tumor. Moreover, mitoxantrone administered two days after intravenous injection of tumor cells obviously reduced the number of lung colonies, while simultaneous injection of the drug did not inhibit colony formation. Mitoxantrone effectively inhibited angiogenesis on the chorioallantoic membrane at doses that did not affect the growth rate of embryos. These results suggest that mitoxantrone, besides its direct antitumor effect on tumor cells, may inhibit lung metastases by inhibiting angiogenesis.
A study on the distribution of dust particles trapped in horseshoe orbit (2009)

Dust particles which are observed as zodiacal light exist around the Earth's orbit and can create a characteristic distribution by the Earth's gravity. This paper investigates the distribution by numerical simulation on the assumption that dust particles trapped in horseshoe orbits contribute the distribution, because the orbit has the following characteristics. The velocity of a trapped dust varies by its location on the horseshoe orbit and the dust will transit with time to wider horseshoe orbit. And this paper also considers the possibility that these particles are trapped or not and reveals that the possibility depends on the dust diameter.
Scalable Multi-Agent Inverse Reinforcement Learning via Actor-Attention-Critic (2020)

Multi-agent adversarial inverse reinforcement learning (MA-AIRL) is a recent approach that applies single-agent AIRL to multi-agent problems where we seek to recover both policies for our agents and reward functions that promote expert-like behavior. While MA-AIRL has promising results on cooperative and competitive tasks, it is sample-inefficient and has only been validated empirically for small numbers of agents -- its ability to scale to many agents remains an open question. We propose a multi-agent inverse RL algorithm that is more sample-efficient and scalable than previous works. Specifically, we employ multi-agent actor-attention-critic (MAAC) -- an off-policy multi-agent RL (MARL) method -- for the RL inner loop of the inverse RL procedure. In doing so, we are able to increase sample efficiency compared to state-of-the-art baselines, across both small- and large-scale tasks. Moreover, the RL agents trained on the rewards recovered by our method better match the experts than those trained on the rewards derived from the baselines. Finally, our method requires far fewer agent-environment interactions, particularly as the number of agents increases.
First evidence of Schmallenberg virus infection in domestic ruminants in Kosovo and Albania. (2021)

Schmallenberg virus (SBV), a novel Orthobunyavirus, emerged in European domestic ruminants in 2011 causing abortions and malformations in newborns and none or mild clinical symptoms in adult animals. Here, a total of 364 bovine, ovine and caprine serum samples were collected in Kosovo and Albania between May 2014 and August 2016 and analyzed for the presence of anti‑SBV antibodies. Sera were tested using an enzyme‑linked immunosorbent assay (ELISA), and 48 ELISA‑positive samples were subsequently analyzed by serum neutralization test (SNT). The overall percentage of ELISA positive results was 17.9%; 23.1% (53/229) was the prevalence observed in Kosovo (cattle 45.5%, sheep 19.2% and goat 6.8%), while 8.9% (12/135) was that observed in Albania (cattle 11.1%, sheep 0% and goat 20.0%). SNT confirmed the presence of neutralizing antibodies against SBV in all samples tested. This is the first study reporting SBV circulation in domestic ruminants in Kosovo and Albania, with indication that this virus has been present in Kosovo and Albania at least since 2014 without being detected.
Induction of bilirubin clearance by the constitutive androstane receptor (CAR) (2003)

Bilirubin clearance is one of the numerous important functions of the liver. Defects in this process result in jaundice, which is particularly common in neonates. Elevated bilirubin levels can be decreased by treatment with phenobarbital. Because the nuclear hormone receptor constitutive androstane receptor (CAR) mediates hepatic effects of this xenobiotic inducer, we hypothesized that CAR could be a regulator of bilirubin clearance. Activation of the nuclear hormone receptor CAR increases hepatic expression of each of five components of the bilirubin-clearance pathway. This induction is absent in homozygous CAR null mice but is observed in mice expressing human CAR instead of mouse CAR. Pretreatment with xenobiotic inducers markedly increases the rate of clearance of an exogenous bilirubin load in wild-type but not CAR knockout animals. Bilirubin itself can also activate CAR, and mice lacking CAR are defective in clearing chronically elevated bilirubin levels. Unexpectedly, CAR expression is very low in livers of neonatal mice and humans. We conclude that CAR directs a protective response to elevated bilirubin levels and suggest that a functional deficit of CAR activity may contribute to neonatal jaundice.
Tolerance and Pharmacokinetics of Single‐Dose Atorvastatin, a Potent Inhibitor of HMG‐CoA Reductase, in Healthy Subjects (1996)

Tolerance and pharmacokinetics after single-dose administration of atorvastatin, an investigational inhibitor of HMG-CoA reductase, were examined in 22 healthy volunteers in a three-period, partially-blinded study. Participants received capsule and solution doses of atorvastatin (0.5 to 120 mg) and placebo at weekly intervals. Atorvastatin was well tolerated at doses as high as 80 mg. The adverse event profile was similar after administration of atorvastatin capsules and placebo. Atorvastatin solution was slightly less well tolerated. The most common side effect after administration of capsules and solution was headache, followed by sporadic reports of diarrhea, flatulence, and nausea. At the 120-mg solution dose, one participant experienced mild, transient restlessness, euphoria, and mental confusion that were considered to be dose-limiting side effects. Mean concentrations of atorvastatin, maximum concentration (Cmax), and area under the concentration-time curve from time 0 to the time of the last detectable concentration (AUCo-tldc) increased with increasing dose. Plasma elimination half-life (t1/2) ranged from 14.7 to 57.6 hours. The bioavailability of atorvastatin capsules was similar to that of solution. These results suggest that atorvastatin is well tolerated after single doses as high as 80 mg, and may require administration only once daily.
Monitoring 3.2 Million Tonnes of CO2 at the Bell Creek Oil Field (2017)

A research-monitoring program is being conducted at the Bell Creek oil field by the Plains CO2 Reduction Partnership, led by the Energy & Environmental Research Center, to evaluate and demonstrate the cost-effectiveness of strategies for monitoring CO2 storage associated with a commercial enhanced oil recovery (EOR) project. The Bell Creek oil field, operated by Denbury Onshore LLC as a commercial EOR project, is an oil-bearing, Lower Cretaceous sandstone reservoir located in southeastern Montana, USA. CO2 injection for commercial EOR began in May 2013 and has resulted in over 3.2 million tonnes of associated CO2 storage as of July 2016.
Growth temperature dependent band alignment at the Ga0.51In0.49P to GaAs heterointerfaces (1996)

Photoluminescence analysis of Ga0.51In0.49P/GaAs single-quantum well structures grown by metal-organic vapor-phase epitaxy in the temperature range from 570 to 720 °C have been carried out. Besides the GaAs band-edge emissions, all SQW samples studied here exhibit a dominant long-wavelength peak, which is attributed to the spatially indirect transition due to the type-II band alignment of Ga0.51In0.49P/GaAs heterojunctions. The energy of the type-II PL emission has been found to depend strongly on the growth temperature indicating the strong influence of the growth temperature on the band alignment. The shifts of the type-II PL emission have been used to estimate the growth temperature dependent conduction and valence band discontinuity of the Ga0.51In0.49P/GaAs heterojunction. X-ray diffraction measurements and simulations using the dynamical theory were carried out to study the influence of the growth temperature on the unintended interfacial layers.
Glycerine-water Solution Humidity-controlling Method and its Effects on SO_2 Atmospheric Corrosion of Hot Galvanized Steel (2013)

The action of humidity on SO_2 atmospheric corrosion of hot galvanized steel and the affecting factors for the glycerine-water solution humidity control method were investigated thoroughly.The volume ratio of 1/100～1/ 125 between the glycerine-water solution and the humidity controlling space and the distance no more than 150 mm were suggested from the coupons to the glycerine-water solution.In the same SO_2 concentration,the corrosion rate of the galvanized steel increased with the increase of the relative humidity.The zinc coating swelled and peeled from the substrate during the SO_2 atmospheric corrosion.The corrosion products showed an acicular and lamellar loose structure.
Non-negative matrix factorization for parameter estimation in hidden Markov models (2010)

Hidden Markov models are well-known in analysis of random processes, which exhibit temporal or spatial structure and have been successfully applied to a wide variety of applications such as but not limited to speech recognition, musical scores, handwriting, and bio-informatics. We present a novel algorithm for estimating the parameters of a hidden Markov model through the application of a non-negative matrix factorization to the joint probability distribution of two consecutive observations. We start with the discrete observation model and extend the results to the continuous observation model through a non-parametric approach of kernel density estimation. For both the cases, we present results on a toy example and compare the performance with the Baum-Welch algorithm.
Wind Turbine Control for Load Reduction (2003)

Abstract This article reviews techniques for the control of wind turbines during power production. Pitch control is used primarily to limit power in high winds, but it also has an important effect on structural loads. Particularly as turbines become larger, there is increasing interest in designing controllers to mitigate loads as far as possible. Torque control in variable‐speed turbines is used primarily to maximize energy capture below rated wind speed, and to limit the torque above rated, but it can also be used to reduce certain loads. The design of the control algorithms is clearly of prime importance. Additional sensors such as accelerometers and load sensors can also help the controller to achieve its objectives more effectively. By controlling the pitch of each blade independently, it is also possible to achieve important further reductions in loading. It is important to be able to quantify the benefits of any new controller. Although computer simulations are useful, field trials are also vital. The variability of the real wind means that particular care is needed in the design of the trials. Copyright © 2003 John Wiley &amp; Sons, Ltd.
Storing information through complex dynamics in recurrent neural networks (2005)

The neural net computer simulations which will be presented here are based on the acceptance of a set of assumptions that for the last twenty years have been expressed in the fields of information processing, neurophysiology and cognitive sciences. First of all, neural networks and their dynamical behaviors in terms of attractors is the natural way adopted by the brain to encode information. Any information item to be stored in the neural net should be coded in some way or another in one of the dynamical attractors of the brain and retrieved by stimulating the net so as to trap its dynamics in the desired item's basin of attraction. The second view shared by neural net researchers is to base the learning of the synaptic matrix on a local Hebbian mechanism. The last assumption is the presence of chaos and the benefit gained by its presence. Chaos, although very simply produced, inherently possesses an infinite amount of cyclic regimes that can be exploited for coding information. Moreover, the network randomly wanders around these unstable regimes in a spontaneous way, thus rapidly proposing alternative responses to external stimuli and being able to easily switch from one of these potential attractors to another in response to any coming stimulus. In this thesis, it is shown experimentally that the more information is to be stored in robust cyclic attractors, the more chaos appears as a regime in the back, erratically itinerating among brief appearances of these attractors. Chaos does not appear to be the cause but the consequence of the learning. However, it appears as an helpful consequence that widens the net's encoding capacity. To learn the information to be stored, an unsupervised Hebbian learning algorithm is introduced. By leaving the semantics of the attractors to be associated with the feeding data unprescribed, promising results have been obtained in term of storing capacity.
MC2: Map Concurrency Characterization for MapReduce on the Cloud (2013)

MapReduce is now a pervasive analytics engine on the cloud. Hadoop is an open source implementation of MapReduce and is currently enjoying wide popularity. Hadoop offers a high-dimensional space of configuration parameters, which makes it difficult for practitioners to set for efficient and cost-effective execution. In this work we observe that MapReduce application performance is highly influenced by map concurrency. Map concurrency is defined in terms of two configurable parameters, the number of available map slots and the number of map tasks running over the slots. We show that some inherent MapReduce characteristics enable well-informed prediction of map concurrency. We propose Map Concurrency Characterization (MC2), a standalone utility program that can predict the best map concurrency for any given MapReduce application. By leveraging the generated predicted information, MC2 can judiciously guide Map phase configuration and, consequently, improve Hadoop performance. Unlike many of relevant schemes, MC2 does not employ simulation, dynamic instrumentation, and/or static analysis of unmodified job code to predict map concurrency. In contrast, MC2 utilizes a simple, yet effective mathematical model, which exploits the MapReduce characteristics that impact map concurrency. We implemented MC2 and conducted comprehensive experiments on a private cloud and on Amazon EC2 using Hadoop 0.20.2. Our results show that MC2 can correctly predict the best map concurrencies for the tested benchmarks and provide up to 2.2X speedup in runtime.
Total skin clearance results in improvements in health-related quality of life and reduced symptom severity among patients with moderate to severe psoriasis (2014)

A higher proportion of subjects with total skin clearance reported no impairment in HRQoL and no psoriasis symptoms than those who were almost clear.
Activation of EGFR on monocytes is required for human cytomegalovirus entry and mediates cellular motility (2009)

Human cytomegalovirus (HCMV) rapidly induces a mobile and functionally unique proinflammatory monocyte following infection that is proposed to mediate viral spread. The cellular pathways used by HCMV to initiate these biological changes remain unknown. Here, we document the expression of the epidermal growth factor receptor (EGFR) on the surface of human peripheral blood monocytes but not on other blood leukocyte populations. Inhibition of EGFR signaling abrogated viral entry into monocytes, indicating that EGFR can serve as a cellular tropism receptor. Moreover, HCMV-activated EGFR was required for the induction of monocyte motility and transendothelial migration, two biological events required for monocyte extravasation into peripheral tissue, and thus viral spread. Transcriptome analysis revealed that HCMV-mediated EGFR signaling up-regulated neural Wiskott-Aldrich syndrome protein (N-WASP), an actin nucleator whose expression and function are normally limited in leukocytes. Knockdown of N-WASP expression blocked HCMV-induced but not phorbol 12-myristate 13-acetate (PMA)-induced monocyte motility, suggesting that a switch to and/or the distinct use of a new actin nucleator controlling motility occurs during HCMV infection of monocytes. Together, these data provide evidence that EGFR plays an essential role in the immunopathobiology of HCMV by mediating viral entry into monocytes and stimulating the aberrant biological activity that promotes hematogenous dissemination.
Studies on sedum alkaloids V. Synthesis and optical resolution of sedamine and sedridine (1959)

Abstract The synthesis of the racemates of the alkaloids sedamine and sedridine, the separation of the racemates, and their resolution into optical antipodes are described, with the exception of the resolution of (±)‐ allo sedridine and so far as no earlier information about these subjects has been given by us. The results are compared with data about the natural products obtained from Sedum acre and Lobelia inflata .
Temporal heterogeneity of regional pulmonary perfusion is spatially clustered (1995)

This study investigates temporal changes in regional pulmonary perfusion. Five dogs were studied with five or six different radiolabeled microspheres being injected via a central vein over 30 s every 20 min. The lungs of each animal were cubed into 1.9 cm3 pieces with spatial coordinates noted for each piece. Within individual pieces, the coefficient of variation of regional perfusion over time was 17.2 +/- 6.8% (SD) and across dogs accounted for 7.26 +/- 5.7% of total perfusion heterogeneity. Temporal variability or "twinkling" was not random. When lung pieces with similar temporal flow patterns were grouped together (regardless of spatial location), groups were more tightly clustered in space than expected by chance. Statistical clustering methods revealed regulation of blood flow on a large scale (lobar arteries), and fractal analyses suggested regulation existed on a smaller scale (arterioles). We conclude that regional pulmonary perfusion is heterogeneous over time in a nonrandom pattern and that pieces clustered by temporal patterns of perfusion are neighbors in the spatial domain.
Monotherapy treatment with chlorthalidone or amlodipine in the systolic blood pressure intervention trial (SPRINT) (2021)

This post hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) examined the performance of chlorthalidone (C) versus amlodipine (A) monotherapies. ANOVA was used to analyze the differences in systolic blood pressure (SBP) response between C and A. Logistic regression was used to examine monotherapy failure (adding a second antihypertensive agent or switching to a different antihypertensive agent) rates. Four hundred ninety-one participants were treated with C monotherapy (n = 210, mean dose = 22 mg/day) or A monotherapy (n = 281, mean dose = 7 mg/day). There was a significant difference in mean SBP reduction between the C and A monotherapies at the third visit (higher reduction with A, adjusted p = .018). Unadjusted analysis showed a higher failure with C in the standard treatment group. Although the average SBP at failure was higher and above the 140 mm Hg cutoff that indicated monotherapy failure with A (142.60) compared with C (138.40), more participants on C failed despite having SBP below the 140 cutoff. This was probably due to decisions made by the investigative teams to change the antihypertensive regimen, because, in their opinion, the clinical picture required it. After adjusting for baseline characteristics, C had higher failure than A only in the standard treatment group (1.64 odds ratio [OR], 95% CI 1.06-2.56, p = .028). A sub-analysis including participants who had never used antihypertensive treatment before randomization had similar results (2.57 OR, 95% CI 1.34-5.02, p = .004). Overall, in SPRINT chlorthalidone was associated with higher monotherapy failure than amlodipine in the standard treatment group because of decisions of the investigative teams.