gebhart/patrepeval huggingface dataset:
Androgen Receptor Up-Regulates Insulin-Like Growth Factor Binding Protein-5 (IGFBP-5) Expression in a Human Prostate Cancer Xenograft* (1999)

The insulin-like growth factor (IGF) binding proteins (IGFBPs) are important modulators of IGF action in many tissues including human prostate. IGFBPs and the androgen receptor (AR) are expressed in CWR22, an androgen-dependent epithelial cell human CaP xenograft that retains biological characteristics of human CaPs, including regression following androgen withdrawal and recurrent growth of AR-containing cells in the absence of testicular androgens beginning several months after castration. Northern blot and in situ hybridization analyses demonstrated that IGFBP-5 is androgen-regulated in CWR22. IGFBP-5 messenger RNA (mRNA) decreased by 90% following castration of tumor-bearing mice compared with noncastrate androgen-stimulated mice. Testosterone treatment of CWR22 tumor-bearing mice 6 or 12 days after castration increased IGFBP-5 mRNA 10- to 12-fold. Levels of other IGFBP mRNAs did not change following androgen withdrawal and replacement. IGFBP-5 protein in tumor extracts bound 125I-labeled IGF-I in ligand blot assays and the amounts of IGFBP-5 measured by immunoblotting paralleled the levels of IGFBP-5 mRNA. Androgen-induced expression of IGFBP-5 was at a maximum level within 24 h after testosterone replacement, whereas the major increase in cell proliferation as measured by Ki-67 immunostaining occurred between 24-48 h. This time course suggested IGFBP-5 may be a mediator of androgen-induced growth of CWR22. In tumors that recurred several months following castration, IGFBP-5 mRNA and protein increased to levels that approached those in androgen-stimulated CWR22 tumors from noncastrate mice. IGFBP-5 immunohistochemical staining of prostate tissue specimens from patients was stronger in androgen-dependent and androgen-independent CaP than in areas of intraepithelial neoplasia (PIN) or benign prostatic hyperplasia (BPH). IGFBP-5 mRNA in these specimens was localized predominantly to stromal cells and IGFBP-5 protein to epithelial cell membranes.
Optical measurement system for two-phase flow in horizontal small tube based on photodiode arrays (2012)

Based on photodiode array, an optical measurement system is established for gas-liquid two-phase flow in small tubes. A method is proposed for characterization and flow regime identification of gas-liquid two-phase flow. In the experiment, different flow regimes are observed in a horizontal glass tube with inner diameter of 4.02mm and outer diameter of 6.12mm, and voltage signals are obtained from the 8-element photodiode array through sensing circuits. Probability density function (PDF) and Fourier transform are used for the analysis on signal characteristics of flow regimes. To identify flow regimes, eigenvalues of the statistics are calculated, then the principal component analysis (PCA) is implemented to reduce the dimensionality of data sets, finally support vector machine (SVM) is applied for identification. Experimental results show that the optical system based on photodiode array is effective in the measurement of gas-liquid two-phase flow parameters in small tubes. The proposed method proves effective in characterization and flow regime identification of gas-liquid two-phase flow, and the experimental results are satisfactory.
Cooperative, distributed localization in multi-robot systems: a minimum-entropy approach (2006)

In this paper, we consider the problem of localization in a multi-robot system. We present a new approach focused on distribution, scalability, and minimum-uncertainty perception. An Extended Kalman Filter (EKF) is used to update an estimate of the robot poses in correspondence to each sensor measurement. An entropic criterion is used, in order to select optimal measurements that reduce the global uncertainty relative to the estimate of the robot poses. It is shown that, in addition to EKF, also the selection of the optimal measurement can be distributed among the robots, in a scalable fashion. The proposed approach has been validated by simulations and preliminary experimental results.
Pattern-dependent noise prediction in signal-dependent noise (2001)

Maximum and near-maximum likelihood sequence detectors in signal-dependent noise are discussed. It is shown that the linear prediction viewpoint allows a very simple derivation of the branch metric expression that has previously been shown as optimum for signal-dependent Markov noise. The resulting detector architecture is viewed as a noise predictive maximum likelihood detector that operates on an expanded trellis and relies on computation of branch-specific, pattern-dependent noise predictor taps and predictor error variances. Comparison is made on the performance of various low-complexity structures using the positional-jitter/width-variation model for transition noise. It is shown that when medium noise dominates, a reasonably low complexity detector that incorporates pattern-dependent noise prediction achieves a significant signal-to-noise ratio gain relative to the extended class 4 partial response maximum likelihood detector. Soft-output detectors as well as the use of soft decision feedback are discussed in the context of signal-dependent noise.
Distinct Roles for N-Ethylmaleimide-sensitive Fusion Protein (NSF) Suggested by the Identification of a Second Drosophila NSF Homolog (1995)

The N-ethylmaleimide-sensitive fusion protein (NSF) is a cytoplasmic protein implicated in the fusion of intracellular transport vesicles with their target membranes. NSF is thought to function in the fusion of essentially all types of vesicles, including endoplasmic reticulum, Golgi, and endocytic vesicles, as well as secretory vesicles undergoing regulated fusion (for review see Rothman, J.E. (1994) Nature 372, 55-63). However, little experimental evidence exists to address the possibility that organisms might have multiple NSF proteins serving distinct functions in the same or different cells. We previously cloned a neurally expressed Drosophila homolog, dNSF-1 (Ordway, R.W., Pallanck, L., and Ganetzky, B. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 5715-5719), and have subsequently identified mutations in this gene that confer an apparent failure of synaptic transmission at elevated temperature (Pallanck, L., Ordway, R.W., and Ganetzky, B. (1995) Nature, 376, 25; Siddiqi, O., and Benzer, S. (1976) Proc. Natl. Acad. Sci. U.S.A. 73, 3253-3257). Here we report that 1) Drosophila contains a second NSF homolog, termed dNSF-2, that exhibits 84% amino acid identity to dNSF-1, 2) dNSF-1 and dNSF-2 display overlapping but different temporal expression, and 3) multiple transcripts are derived from the dNSF-2 gene. These findings raise the possibility that different NSF gene products serve distinct or overlapping functions with the organism.
FTIR and UV‒vis study of chemically engineered biomaterial surfaces for protein immobilization (2002)

The biomaterials research field has broadened in the last 3 decades, including replacement of diseased or damaged parts, assist in healing, correct and improve functional abnormality, drug delivery systems, immunological kits and biosensors. Proteins play crucial role in almost every biological system. They are involved in enzymatic catalysis, transport and storage, coordinated motion, mechanical support, immune protection, control of growth and cell differentiation among many others. The immobilization of proteins onto surface functionalized substrates has been one of the most promising areas in bioengineering field. It is important to note that the term immobilization can refer either to a temporary or to a permanent localization of the biomolecule on or within a support. Proteins have very particular chain configurations and conformations that promote high levels of specificity during chemical interactions. In the present work, we aimed to study the phenomenon of protein immobilization onto biomaterial with chemically engineered surface. We have tailored the surface of the porous gels of SiO 2 with 5 different silane surface modifying agents: tetraethoxysilane (TEOS), 3‒mercaptopropyltrimethoxysilane (MPTMS) and 3‒aminopropyltriethoxysilane (APTES), 3‒glycidoxypropyltrimethoxysilane (GPTMS) and 3‒isocyanatopropyltriethoxysilane (ICPES). Fourier Transform Infrared Spectroscopy (FTIR) was used to characterize the presence of all specific chemical groups in the materials. The surface functionalized gels were then immersed in porcine insulin (PI) solutions for protein immobilization. The incorporation of protein within the gels was also monitored by FTIR spectroscopy. The kinetics of protein adsorption and desorption from the gel matrix in vitro tests were monitored by UV‒visible spectroscopy. We could not observe any evidence of denaturation of insulin after its desorption from gel matrices using UV‒visible spectroscopy technique. In vivo tests with adult male rats were used to verify the immobilized insulin bioactivity after implantation of different biomaterial with functionalized surfaces. Plasma glucose levels were obtained by using the Glucose GOD‒ANA Colorimetric Assay. All surface modified materials have presented acute hypoglycemic peak response associated with the insulin bioactivity.
Flight Demonstrations of Self-directed Collaborative Navigation of Small Unmanned Aircraft (2004)

The development of small, autonomous UAVs that can operate in complex environments as part of large coordinated groups will enable many new applications at fractions of the cost of current systems. A fleet of fixed-wing aircraft has been developed to create an intelligent aerial platform that has demonstrated various autonomous capabilities. By means of a downward-looking camera, a single aircraft autonomously follows a roadway using the natural features of the scene in conjunction with onboard sensors, without the use of GPS or prior knowledge of the road’s coordinates. A forward looking camera is used to perceive obstacles in the aircraft’s flight path by segmenting images into sky/no-sky regions and classifying no-sky regions above the horizon as obstacles. The tracking of friendly ground vehicles – for which GPS information is known but path information is not – is performed using circular and sinusoidal orbits to maintain desired proximity regardless of ground vehicle motion. Teams of two or three aircraft demonstrate convoy protection by providing persistent surveillance around a moving ground vehicle. The team either flies in rigid formation, providing a large area of coverage around the ground vehicle, or the aircraft coordinate several separate actions that provide both lateral (side to side) and longitudinal (front to back) surveillance of the ground vehicle’s path. Details of the hardware platform and each capability are described and results of flight demonstrations are presented.
β-Sitosterol Reduces the Expression of Chemotactic Cytokine Genes in Cystic Fibrosis Bronchial Epithelial Cells (2017)

Extracts from <i>Nigella arvensis</i> L. seeds, which are widely used as anti-inflammatory remedies in traditional medicine of Northern Africa, were able to inhibit the expression of the pro-inflammatory neutrophil chemokine Interleukin (IL)-8 in Cystic Fibrosis (CF) bronchial epithelial IB3-1 cells exposed to the Gram-negative bacterium <i>Pseudomonas aeruginosa</i>. The chemical composition of the extracts led to the identification of three major components, β-sitosterol, stigmasterol, and campesterol, which are the most abundant phytosterols, cholesterol-like molecules, usually found in plants. β-sitosterol (BSS) was the only compound that significantly reproduced the inhibition of the <i>P. aeruginosa</i>-dependent expression of IL-8 at nanomolar concentrations. BSS was tested in CF airway epithelial CuFi-1 cells infected with <i>P. aeruginosa</i>. BSS (100 nM), showed a significant and consistent inhibitory activity on expression of the <i>P. aeruginosa</i>-stimulated expression chemokines IL-8, GRO-α GRO-β, which play a pivotal role in the recruitment of neutrophils in CF inflamed lungs. Preliminary mechanistic analysis showed that BSS partially inhibits the <i>P. aeruginosa</i>-dependent activation of Protein Kinase C isoform alpha, which is known to be involved in the transmembrane signaling activating IL-8 gene expression in bronchial epithelial cells. These data indicate BSS as a promising molecule to control excessive lung inflammation in CF patients.
The expression of CYP2W1: a prognostic marker in colon cancer. (2012)

The results of the current study were in agreement with those of the previous pilot study and show that higher expression of CYP2W1 seems to be of prognostic value in colon cancer. Furthermore, we found equal expression in slices from two different areas of the same tumor. Since the CYP2W1 enzyme has been shown to catalytically activate compounds to cytotoxic products, the enzyme might be used as a novel drug target for the treatment of colon cancer.
A Degradation Model for Solid Oxide Fuel Cell Anodes due to Impurities in Coal Syngas: Part I Theory and Validation (2012)

Abstract A new phenomenological one‐dimensional model is formulated to simulate the typical degradation patterns observed in solid oxide fuel cell (SOFC) anodes due to coal syngas contaminants such as arsenic (As) and phosphorous (P). The model includes gas phase diffusion and surface diffusion within the anode and the adsorption reactions on the surface of the Ni‐YSZ‐based anode. Model parameters such as reaction rate constants for the adsorption reactions are obtained through indirect calibration to match the degradation rates reported in the literature for arsine (AsH 3 ), phosphine (PH 3 ), hydrogen sulfide (H 2 S), and hydrogen selenide (H 2 Se) under accelerated testing conditions. Results from the model demonstrate that the deposition of the impurity on the Ni catalyst starts near the fuel channel/anode interface and slowly moves toward the active anode/electrolyte interface as observed in the experiments. Parametric studies performed at different impurity concentrations and operating temperatures show that the coverage rate increases with increasing temperature and impurity concentration, as expected. The calibrated model was then used for prediction of the performance curves at different impurity concentrations and operating temperatures. Good agreement is obtained between the predicted results and the experimental data reported in the literature.
Accurate two-dimensional eye tracker using first and fourth Purkinje images (1973)

Although a number of devices are currently in use for monitoring eye position, none is both accurate and convenient to use. Methods based on the use of contact lenses can provide high accuracy but have obvious inconveniences. Other techniques—e.g., skin-mounted electrodes, or eyeglass-mounted photoelectric pickups—are relatively convenient, but eye position can be measured to an accuracy of no better than about 0.5° to 1°. A novel eye-tracking instrument has been developed that makes use of two Purkinje images. The instrument operates in the infrared, so that it does not interfere with normal vision; it requires no attachments to the eye; it has a sensitivity and accuracy of about 1 min of arc, and operates over a two-dimensional visual field of 10° to 20° in diameter. The basic principle of the instrument is described, and operating records are shown.
Cross Modal Focal Loss for RGBD Face Anti-Spoofing (2021)

Automatic methods for detecting presentation attacks are essential to ensure the reliable use of facial recognition technology. Most of the methods available in the literature for presentation attack detection (PAD) fails in generalizing to unseen attacks. In recent years, multi-channel methods have been proposed to improve the robustness of PAD systems. Often, only a limited amount of data is available for additional channels, which limits the effectiveness of these methods. In this work, we present a new framework for PAD that uses RGB and depth channels together with a novel loss function. The new architecture uses complementary information from the two modalities while reducing the impact of overfitting. Essentially, a cross-modal focal loss function is proposed to modulate the loss contribution of each channel as a function of the confidence of individual channels. Extensive evaluations in two publicly available datasets demonstrate the effectiveness of the proposed approach.
Designing a Framework for Scalable Coordination of Wireless Sensor Networks, Context Information and Web Services (2007)

Context-aware services are one of the key applications in the ubiquitous computing environment where physical and virtual information are seamlessly integrated across the network. However, so far we have found few discussions on architectural styles for such integration of wireless sensor networks and other networks services and objects. Conventional context aware services have been built in an ad-hoc manner, making it difficult to build new applications or evolve existing ones. The objective of this paper is to discuss the architectural requirements from several points of view such as entry barrier, extensibility, interoperability, and scalability. Then we show a service coordination framework based on REST architectural style.
ChemInform Abstract: Vanadium Phosphorus Oxides: A Reference Catalyst for Mild Oxidation of Light Alkanes (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Tables 1-4 from Diagnostic and Prognostic MicroRNAs in Stage II Colon Cancer (2023)

Supplementary Tables 1-4 from Diagnostic and Prognostic MicroRNAs in Stage II Colon Cancer
Online Multi-Task Learning via Sparse Dictionary Optimization (2014)

This paper develops an efficient online algorithm for learning multiple consecutive tasks based on the K-SVD algorithm for sparse dictionary optimization. We first derive a batch multi-task learning method that builds upon K-SVD, and then extend the batch algorithm to train models online in a lifelong learning setting. The resulting method has lower computational complexity than other current lifelong learning algorithms while maintaining nearly identical model performance. Additionally, the proposed method offers an alternate formulation for lifelong learning that supports both task and feature similarity matrices.
Radiative lifetime of the metastable1S0level in Kr2+measured using an electrostatic ion trap (2015)

We have measured the radiative lifetime of the 1S0 metastable level in Kr2+ using an electrostatic ion trap. The obtained lifetime was 17.4 ± 0.4 ms. Comparing with the previous results, our value is consistent with the theoretical predictions, but inconsistent with the experimental results even considering their errors.
Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine (2013)

This paper describes the examination of humoral and cellular immune mechanisms induced by PfCSP-SAPN vaccination which result in sterile host protection against a transgenic P. berghei malaria sporozoite expressing the P. falciparum CSP, and which significantly inhibits native P. falciparum sporozoites from invading and developing within cultured human hepatocytes. These results may indicate the type and mode of action of protective antibodies needed to control P. falciparum sporozoites from infecting humans as well as a potential mechanism of induction of protective long-lived effector memory CD8+ T-cells.
Feasibility of retroreflective transdermal optical wireless communication (2012)

There is an increasing demand for transdermal high-data-rate communication for use with in-body devices, such as pacemakers, smart prostheses, neural signals processors at the brain interface, and cameras acting as artificial eyes as well as for collecting signals generated within the human body. Prominent requirements of these communication systems include (1) wireless modality, (2) noise immunity and (3) ultra-low-power consumption for the in-body device. Today, the common wireless methods for transdermal communication are based on communication at radio frequencies, electrical induction, or acoustic waves. In this paper, we will explore another alternative to these methods--optical wireless communication (OWC)--for which modulated light carries the information. The main advantages of OWC in transdermal communication, by comparison to the other methods, are the high data rates and immunity to external interference availed, which combine to make it a promising technology for next-generation systems. In this paper, we present a mathematical model and experimental results of measurements from direct link and retroreflection link configurations with Gallus gallus domesticus derma as the transdermal channel. The main conclusion from this work is that an OWC link is an attractive communication solution in medical applications. For a modulating retroreflective link to become a competitive solution in comparison with a direct link, low-energy-consumption modulating retroreflectors should be developed.
Risk assessment of endocrine disrupting phthalates and hormonal alterations in children and adolescents (2018)

Risk assessment and hormone evaluation were carried out for di(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP), endocrine disrupting chemicals (EDCs), in 302 Korean children (n = 223) and adolescents (n = 79) (< age 19). Urinary and serum concentrations of DEHP, MEHP (mono(2-ethylhexyl) phthalate), DBP, MBP (monobutyl phthalate), and PA (phthalic acid, a common final metabolite of phthalates) were detected in children and adolescents. Daily exposure levels were estimated to be 16.45 ± 36.50 μg/kg b.w./day for DEHP, which is one-third of the tolerable daily intake (TDI) value (50 μg/kg b.w./day), but 14 out of 302 participants had a hazard index (HI = intake/TDI) value >1. The mean daily exposure level of DBP was 1.23 ± 1.45 μg/kg b.w./day, which is one-eighth of the TDI value (10 μg/kg b.w./day), but 1 out of 302 participants had a HI value > 1. Positive correlations were observed between serum DBP or MEHP, and serum estradiol (E2) and/or luteinizing hormone (LH) in prepubescent children. In addition, serum MBP levels were found to be negatively correlated with serum triiodothyronine (T3) or thyroxine (T4) in male participants, and serum DEHP levels with serum thyroid stimulating hormone (TSH) in female adolescents. Low-density lipoprotein (LDL) levels were positively correlated with serum PA levels in children and adolescents. DEHP, DBP or its metabolites may be associated with altered hormone levels in children and adolescents. Data suggest that exposure levels of DEHP and DBP in Korean children need to be reduced to levels below TDI to protect them from EDC-mediated toxicities. Abbreviations: DBP: dibutyl phthalate; DEHP: di(2-ethylhexyl) phthalate; E2: estradiol; EDC: endocrine disrupting chemical; EFSA: European Food Safety Authority; FSH: follicle stimulating hormone; HDL: high density lipoprotein; HI: hazard index; LDL: low density lipoprotein; LH: luteinizing hormone; MEHP: mono(2-ethylhexyl) phthalate; MBP: monobutyl phthalate; PA: phthalic acid; PPAR: peroxisome proliferator-activated receptor gamma; PVC: polyvinyl chloride; T3: triiodothyronine; T4: thyroxine; TDI: tolerable daily intake; TG: triglyceride; TSH: thyroid stimulating hormone; UPLC/MS/MS: Ultra Performance Liquid Chromatography/Tandem Mass Spectrometry; WWF: World Wildlife Fund.