gebhart/patrepeval huggingface dataset:
Universality of iterated networks (1992)

The multistage shuffle-exchange network is generalized, by replacing the perfect shuffle with an arbitrary permutation π, in order to pass all permutations using aminimal number of stages. The universality of such a network is shown to be equivalent to theprimitivity of a related regular digraph, thus showing that universality is decidable in polynomial time. Extensive computational results are presented that characterizeall nonisomorphic minimal networks with up to 12 inputs. In addition, strong evidence is presented relating the minimal number of network stages needed to achieve universality totwice the index of primitivity of the corresponding digraph.
DNA motions in the nucleosome core particle. (1982)

We have used time-resolved triplet state anisotropy decay techniques to measure the conformational flexibility of DNA in the nucleosome. From these measurements we conclude that, in a nucleosome, the DNA helix experiences substantial internal flexibility, which occurs with a time constant near 30 nsec. We find that our data can be fit well by a modified version of the Barkley-Zimm model for DNA motion, allowing only DNA twisting motions and the overall tumbling of the nucleosome. That fit yields a calculated torsional rigidity equal to 1.8 X 10(-19) erg X cm, a value equal to that measured for uncomplexed DNA. We conclude from such similarity that large, fast twisting motions of the DNA helix persist, nearly unaltered, when DNA is wrapped to form a nucleosome.
Individualization of stochastic models from population statistics for blood glucose regulation in Type 1 diabetes patients (2016)

This paper shows how a stochastic model for Type 1 diabetes with parameters relevant to a class of individuals can be specialized to a particular patient using Bayesian Inference.
[A Case of Distal Bile Duct Cancer Occurring 38 Years after Cyst-to-Duct Anastomosis for a Congenital Biliary Dilatation]. (2016)

A 41-year-old woman had undergone cyst-to-duct anastomosis for a congenital biliary dilatation when she was 3-yearold. After 38 years, she presented with a high fever, and laboratory findings showed elevation of liver and biliary enzyme levels. A CT scan showed a mass lesion in a choledochal cyst, and an adenocarcinoma was found in the anastomosis of the choledochal cyst and duodenum. We diagnosed distal bile duct cancer and performed SSPPD after neoadjuvant chemotherapy( gemcitabine plus cisplatin plus S-1). The resected tumor was pathologically diagnosed as papillary-infiltrating adenocarcinoma( ypT2N1M0, ypStage II B). Currently, 9 months after the second surgery, the patient is doing well without any signs of recurrence. The current case suggested the necessity of postoperative lifetime follow-up for patients with bile duct cancer who have undergone radical cyst excision for a congenital biliary dilatation.
Normalization-Based Validity Index of Adaptive K-Means Clustering for Multi-Solution Application (2020)

Validity evaluation aims to analyze the quality of the clustering algorithm with different measurement criteria. A variety of assessment methods have been introduced in the application of pattern recognition and computer vision. Although it is well known that mining information of massive data is essential, most of the validity indices only provide a single partitioning scheme for clustering validation. Moreover, the conventional evaluation algorithm is susceptible to the density and dimension of the dataset, which leads to assessment failure. In this paper, a normalization-based validity index (NbVI) is proposed for validity evaluation of the adaptive K-means clustering from a multi-solution perspective. According to the concept of high-compact within clusters and high-separation among groups, NbVI attempts to find the maximum relative ratio between normalized inter-distance and normalized intra-distance. The experimental results demonstrate that the proposed NbVI method exhibits excellent performance for the clustering of the density-unbalanced dataset for multi-solution applications. Moreover, the NbVI validation shows high versatility using different clustering algorithms.
A Proposal of Remaining Useful Time Prediction Utilizing Operation Data of Construction Machinery (2021)

For users to carry out various jobs according to the construction plan, if unexpected machine failures occur and their machines go down for an extended time, they will be huge losses. Therefore, machine maintenances are required for their machines to prevent from machine failures. However, due to operation in severe environment condition such as high load or long time use and in unexpected use, they often fail earlier than expected. For the maintenance of construction machinery, we propose to detect early indications of failure by predicting remaining useful times. Thereby, their machines can be performed maintenance before their failures and prevent unexpected machine failures. We propose to predict the machine failures of lower traveling bodies of hydraulic excavators by estimating their remaining useful times. Moreover, we also propose a practical example of maintenance activity using remaining useful times prediction in addition to failure prediction by neural network for hydraulic excavators and its effectiveness is shown.
Role of the through-space 2p-3d overlap effect in the Wittig reaction (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRole of the through-space 2p-3d overlap effect in the Wittig reactionWilliam E. McEven and John V. CooneyCite this: J. Org. Chem. 1983, 48, 7, 983–987Publication Date (Print):April 1, 1983Publication History Published online1 May 2002Published inissue 1 April 1983https://pubs.acs.org/doi/10.1021/jo00155a010https://doi.org/10.1021/jo00155a010research-articleACS PublicationsRequest reuse permissionsArticle Views192Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The TA2 Database - A Multi-Modal Database From Home Entertainment (2011)

Abstract—This paper presents a new database containing highdefinition audio and video recordings in a rather unconstrained video-conferencing-like environment. The database consists of recordings of people sitting around a table in two separate rooms communicating and playing online games with each other. Extensive annotation of head positions, voice activity and word transcription has been performed on the dataset, making it especially useful for evaluating automatic speech-recognition, voice activity detection, speaker localisation, multi-face detection and tracking, and other audio-visual analysis algorithms.
Dissociated responses at initial computed tomography evaluation is a good prognostic factor in non-small cell lung cancer patients treated with anti-program cell death-1/ligand 1 inhibitors (2019)

Abstract Background: Dissociated responses (DR) are phenomena in which some tumors shrink, whereas others progress during treatment of patients with cancer. The purpose of the present study was to evaluate the frequency and prognosis of DR in non-small cell lung cancer (NSCLC) patients treated with anti-program cell death-1/ligand 1 (anti-PD-1/L1) inhibitors. Methods: This retrospective study included NSCLC patients who received anti-PD-1/L1 inhibitor as second- or later-line treatment. We excluded patients without radiological evaluation. In patients who showed progressive disease (PD) according to the RECIST 1.1 at the initial CT evaluation, we evaluated all measurable lesions in each organ to identify DR independently of RECIST 1.1. We defined DR as a disease with some shrinking lesions as well as growing or emerging new lesions. Cases not classified as DR were defined as ‘true PD’. Overall survival was compared between patients with DR and those with true PD using Cox proportional hazards models. Results: The present study included 62 NSCLC patients aged 27–82 years (median: 65 years). DR and true PD were observed in 11 and 51 patients, respectively. The frequency of DR in NSCLC patients who showed PD to anti-PD-1/L1 was 17.7%. Median overall survival was significantly longer in patients with DR versus true PD (14.0 vs. 6.6 months, respectively; hazard ratio for death: 0.40; 95% confidence interval: 0.17–0.94). Conclusions: Patients with DR exhibited a relatively favorable prognosis.
Selective loss of elastase inhibitory activity of alpha 1-proteinase inhibitor upon chemical modification of its tyrosyl residues. (1981)

Nitration or acetylation of tyrosine residues of human plasma alpha 1-proteinase inhibitor (alpha 1-PI) with tetranitromethane or N-acetylimidazole resulted in a selective loss of its inhibitory activity. While the chymotrypsin- and trypsin-inhibitory activities were unaffected, all of the elastase inhibiting activity was lost. Comparative amino acid analyses of the native inhibitor and the chemically modified derivatives revealed no differences in the amino acid compositions with the exception that in the case of the tetranitromethane-treated material there were losses in the tyrosine content which could be accounted for by the formation of 3-nitrotyrosine. Nitration of alpha 1-PI.trypsin, alpha 1-PI.chymotrypsin, and alpha 1-PI.elastase complexes with excess tetranitromethane indicated that complex formation protected the binding site of the inhibitor for elastase, but not for trypsin or chymotrypsin. Quantitative estimation of the number of nitrotyrosine residues in the alpha 1-PI isolated from the complexes has shown that one tyrosine residue was protected from nitration. Competition studies have also indicated that the elastase inhibitory site is different from that of trypsin or chymotrypsin, although the possibility of overlapping sites could not be disregarded.
KLF6-SV1 accelerates prostate cancer progression and metastasis (2008)

349 The molecular mechanisms underlying the transition from localized tumour to disseminated, hormone refractory prostate cancer (PCa) remain largely unknown. Here we demonstrate that increased tumor expression of KLF6-SV1, a splice variant of the KLF6 tumor suppressor gene, predicts a markedly poorer survival and disease recurrence profile in men following prostatectomy. As would be expected, KLF6-SV1 levels are specifically upregulated in hormone refractory, metastatic PCa. In two complementary mouse models, in vivo and ex vivo bioluminescent imaging of KLF6-SV1 overexpressing tumor cells demonstrated more rapid and frequent and increased dissemination to lymph nodes, bone, and brain, whereas increased KLF6-SV1 expression did not impact localized tumor growth. In accord with its role as a prosurvival protein, KLF6-SV1 inhibition using RNA interference induced spontaneous apoptosis in cell culture and suppressed tumor growth in vivo. Together, these findings demonstrate that KLF6-SV1 expression levels, in tumors at the time of diagnosis or in genetically engineered cells, can define the metastatic behaviour of prostate cancer and that this metastasis promoter gene may thus represent a novel therapeutic target.
A randomized, open-label, phase II study of anti-NaPi2b antibody-drug conjugate (ADC) lifastuzumab (Lifa) vedotin (DNIB0600A) compared to pegylated liposomal doxorubicin (PLD) in patients (pts) with platinum-resistant ovarian cancer (PROC). (2016)

5569 Background: NaPi2b is a transmembrane, sodium-dependent phosphate transporter expressed in ~90% of OC. Lifa, a humanized anti-NaPi2b monoclonal antibody conjugated to the anti-mitotic agent MMAE, was investigated in OC. Methods: The Phase 2 study evaluated the efficacy and safety of lifa at 2.4 mg/kg given intravenously (IV) every 3 weeks (q3w), compared to PLD (40 mg/m2 IV) given q4w, in pts with PROC. The primary endpoint was progression-free survival (PFS) assessed by investigators in intent to treat (ITT) and in NaPi2b-high (IHC 2+/3+) patients. Secondary endpoints included PFS by independent review, safety, and patient-reported outcomes. Tumor NaPi2b expression was assessed by immunohistochemistry (IHC) and quantitative PCR in archival tissue. Results: 95 pts were randomized (47 lifa; 48 PLD). For both arms, the median age was 62, and the median number of prior systemic therapies was 2. 87% of lifa and 85% of PLD pts had no prior PROC therapy. The stratified PFS hazard ratio was 0.78 (95% CI: 0.46-1.31, p = 0.34) with a median PFS of 5.3 months (lifa) vs. 3.1 months (PLD) in the ITT population, and 0.71 (95% CI: 0.40-1.26, p = 0.24) with a median PFS of 5.3 months (lifa) vs. 3.4 months (PLD) in NaPi2b-highpatients. The objective response rate was 34% (95% CI: 22-49%, lifa) vs. 15% (95% CI: 7-28%, PLD) in the ITT population, and 36% (95% CI: 22-52%, lifa) vs.14% (95% CI: 6-27%, PLD) in NaPi 2+/3+ patients per RECIST v1.1. Subgroup analyses demonstrated most benefit in the highest quartile of NaPi2b expressers. Toxicities were: Grade ≥ 3 AEs (46% lifa; 51% PLD), serious AEs (30% lifa; 30% PLD), and AEs leading to discontinuation of drug (9% lifa; 13% PLD). Grade ≥ 2 neuropathy was reported in 5 (11%) lifa patients vs. 2 (4%) receiving PLD. Global HRQOL showed no decline in the lifa arm and a clinically significant decline in the PLD arm over 24 weeks. Conclusions: This is the first randomized study of an MMAE ADC compared to standard of care in PROC. Lifa q3w was well-tolerated with improved ORR and a trend towards increased PFS compared to PLD. These data support using an ADC to target NaPi2b in OC. Clinical trial information: NCT01991210.
Secondary metabolites from marine sponge-associated fungus Hansfordia sp. (2013)

Objective To investigate the secondary metabolites of marine sponge-associated fungus Hansfordia sp.Methods The compounds were isolated by sillica gel,Sephadex-LH20 and semi-prepative HPLC chromatography and the NMR,MS spectroscopic analysis were employed for the structural elucidation.Results Eight compounds were isolated from the EtOAc extract of mycelia of Hansfordia sp.and identified as 1,3,6-trihydroxy-8-methylxanthone(1),4-chloro-1,3,6-triroxy-8-methylxanthone(2),6-hydroxymellein(3),4-hydroxymellein(4),3-(2-hydroxypropyl)-8-hydroxy-3,4-dihydroisocoumarin(5),2,5-dimethyl-7-hydroxychromone(6),regiolone(7)and cyclonerodiol(8).Conclusion All the compounds are isolated for the first time from genus Hansfordia.
Biochemical basis for cytotoxicity of 7,12-dimethylbenz(a)anthracene in rat liver epithelial cells. (1979)

When the effects of 7,12-dimethylbenz(a)anthracene (DMBA) on normal and malignant rat liver epithelial cells were compared in a colony inhibition assay, this carcinogen showed a preferential cytotoxic action on the normal cells. In investigations of the biochemical basis of this selective toxicity, it was found that both cell lines were similarly effective in binding DMBA to DNA and that both cell lines had the capacity to metabolize this carcinogen. However, the hepatoma cells were more efficient than were the normal cells in generating very polar metabolites (not organic solvent extractable). These studies suggest that the basis of the resistance of the hepatoma cells to the toxicity induced by DMBA lies in their ability to detoxify biologically active metabolites. Several phenols were examined as possible toxic metabolites of DMBA, but these were not toxic at dose levels at which DMBA kills most of the normal cells.
Etiology of childhood diarrhea in Korea (1989)

To assess the role of recently recognized enteropathogens in childhood diarrhea in Korea, 231 children with diarrhea admitted to and 104 children without diarrhea seen at the well-baby clinic or the outpatient department of Hanyang University Hospital in Seoul, Korea, were evaluated during a 14-month period. Stools were cultured for bacterial pathogens, including enterotoxigenic (heat-labile and heat-stable enterotoxin-producing) and enteroadherent organisms. Only those stools obtained from patients with diarrhea were examined for rotavirus. All Escherichia coli isolates were screened for Shiga-like toxin (SLT) I, SLT-II, enterohemorrhagic E. coli fimbriae, and enteroinvasiveness by colony hybridization. One or more pathogens were identified in 75.8% of the children with diarrhea. Rotavirus was the most frequently identified pathogen, accounting for 47% of the cases. Other major enteropathogens were enterotoxigenic E. coli (22%), Clostridium difficile (16%), enteroadherent E. coli (15%), and enteropathogenic E. coli (6%). Shigella spp., Campylobacter jejuni, Salmonella spp., SLT-I-and enterohemorrhagic-E. coli-fimbria-probe-positive E. coli serotype O26:H11 and enteroinvasive E. coli were isolated from only a few patients. Aeromonas hydrophila and E. coli O157 were not isolated. Compared with those of the controls, the isolation rates of heat-stable-enterotoxin-producing E. coli (P less than 0.05), C. difficile (P less than 0.025), and enteroadherent E. coli (P less than 0.05) were significantly higher in the patients with diarrhea. The greatest number of rotavirus, enterotoxigenic E. coli, and C. difficile cases were identified during the cool, dry months of October and November.
Supercritical Brayton Power Conversion with a Direct Cooled Reactor for Space Power (2018)

To achieve future goals in space exploration a long life, compact power system will be necessary, and nuclear power sources are a promising option. The goal of this project is to achieve mass optimization with a supercritical Brayton Cycle coupled to a direct-cooled nuclear reactor. It is critical to minimize the total mass of this system because of space launch costs. The total mass involves both the components’ masses as well as the fuel mass which is related to system efficiency. This paper discusses a project in which a detailed reactor model is integrated with a carefully constructed cycle model in order to simultaneously optimize the design of these two aspects of the system. Component models are discussed as well as an initial optimization study. A robust, simple recuperated Brayton cycle model is complete and is in the process of integration with a developing reactor model. Preliminary observations of the cycle model have led to the conclusion that there will be an optimum point between a large recuperator and small reactor with high system efficiency, and a large reactor and small recuperator with low recuperator mass for any given radiater size. Once the reactor model is integrated into the cycle optimization, the tradeoffs between the sizes of the radiator, recuperator, and reactor will be further investigated and an optimum system mass will be apparent.
La protección pública a la infancia en Almería, durante el franquismo (2007)

La presenta investigacion, que se enmarca dentro de la historia de la educacion pretende poner de manifiesto cual fue el papel del estado, en la atencion socio-educativa de la infencia y la juventud en diferentes sicuaciones de abandono o de familias en dificultades economicas, a traves de diversas instituciones publicas en la proteccion a la infancia en el periodo que va desde 1939-1970, en la provincia de Almeria. De igual forma pretende poner de manifiesto la evolucion de estas politicas en el periodo descrito y el nivel de coordinacion entre las instituciones.

Partiendo de la situacion de necesidad en que vivian, se hace una descripcion de la labor llevada a cabo por la instituciones y servicios publicos de tipo asistencial (Casa Cuna Provincial, Comedores Infantiles, Centros de Alimentacion Infantil, Centros de Maternologia y Casas de la Madre, Hogar Maritimo, Guarderias, Preventorio Infantil, Ayudas a la Lactancia de Gemelos y a los Huerfanos) como de tipo educativo (Hogares Infantiles y Escolares, Tribunal Tutelar de Menores, Escuela Hogares, Centro para Ninos Subnormales y Proteccion Escolar en forma de becas, Ayudas a los ninos y ninas de poblacion ultradiseminada y de bajas capacidades psiquicas y sensoriales auditivos)
Latest ArF light source with speckle reduction technology for immersion lithography improving chip yield (2021)

Chipmakers have used cross-platform of both EUV exposure and ArF immersion multi-patterning exposure depending on cost effectiveness at each layer. ArF immersion exposure has been required lower linewidth roughness(LWR) to reduce cross matched machine overlay(xMMO) which is the overlay between the different platforms. ArF light sources essentially produce speckle as non-uniform intensity distribution resulting from interference effects generated within a beam. It leads to increase LWR, which results in increasing xMMO. The latest ArF immersion light source, GT66A is introduced a new optical pulse stretcher(OPS) that increases pulse duration to reduce speckle by 30% to improves LWR, which reduces xMMO. This technology will improve chip yield for chipmakers in the processes mixed ArF immersion exposure and EUV exposure.
Radical Polymerization of Alkyl 2-Cyanoacrylates (2018)

Cyanoacrylates (CAs) are well-known fast-setting adhesives, which are sold as liquids in the presence of stabilizers. Rapid anionic polymerization on exposure to surface moisture is responsible for instant adhesion. The more difficult, but synthetically more useful radical polymerization is only possible under acidic conditions. Recommendations on the handling of CAs and the resulting polymers are provided herein. In this review article, after a general description of monomer and polymer properties, radical homo- and copolymerization studies are described, along with an overview of nanoparticle preparations. A summary of our recently reported radical polymerization of CAs, using reversible addition-fragmentation chain transfer (RAFT) polymerization, is provided.
[Treatment of bone infection by plaster of Paris pellets impregnated with antibiotics]. (1990)

In two prospective clinical trials, the authors treated 83 chronic osteomyelitis from various origins by sequestrectomy completed with insertion of Plaster of Paris pellets impregnated with antibiotics. After a review of the experimental and clinical reports on the subjects, the authors give their results: 61.5% of healings and 38.5% of failures. Because of the small number of cases, it was not possible to find out an explanation for this fair results. However wide extension of the lesions, which is frequent in chronic haematogenous osteomyelitis, seems to be a contraindication to the technics. The authors conclude to the necessity of carrying up new experiments with new antibiotics and large series of patients in order to point out the righted indications of the method.