gebhart/patrepeval huggingface dataset:
Resveratrol and cancer: focus on in vivo evidence (2014)

Resveratrol is a naturally occurring polyphenol that provides a number of anti-aging health benefits including improved metabolism, cardioprotection, and cancer prevention. Much of the work on resveratrol and cancer comes from in vitro studies looking at resveratrol actions on cancer cells and pathways. There are, however, comparatively fewer studies that have investigated resveratrol treatment and cancer outcomes in vivo, perhaps limited by its poor bioavailability when taken orally. Although research in cell culture has shown promising and positive effects of resveratrol, evidence from rodents and humans is inconsistent. This review highlights the in vivo effects of resveratrol treatment on breast, colorectal, liver, pancreatic, and prostate cancers. Resveratrol supplementation in animal models of cancer has shown positive, neutral as well as negative outcomes depending on resveratrol route of administration, dose, tumor model, species, and other factors. Within a specific cancer type, there is variability between studies with respect to strain, age, and sex of animal used, timing and method of resveratrol supplementation, and dose of resveratrol used to study cancer endpoints. Together, the data suggest that many factors need to be considered before resveratrol can be used for human cancer prevention or therapy.
High-power UV electron-beam-ionization laser using the excimer XeCl (1982)

Gene therapy is manipulation in/of gene expression in specific cells/tissue to treat diseases. This manipulation is carried out by introducing exogenous nucleic acids, such as DNA or RNA, into the cell. Because of their negative charge and considerable larger size, the delivery of these molecules, in general, should be mediated by gene vectors. Non-viral vectors, as promising delivery systems, have received considerable attention due to their low cytotoxicity and non-immunogenicity. As research continued, more and more functional non-viral vectors have emerged. They not only have the ability to deliver a gene into the cells but also have other functions, such as the performance of fluorescence imaging, which aids in monitoring their progress, targeted delivery, and biodegradation. Recently, many reviews related to non-viral vectors, such as polymers and cationic lipids, have been reported. However, there are few reviews regarding functional non-viral vectors. This review summarizes the common functional non-viral vectors developed in the last ten years and their potential applications in the future. The transfection efficiency and the transport mechanism of these materials were also discussed in detail. We hope that this review can help researchers design more new high-efficiency and low-toxicity multifunctional non-viral vectors, and further accelerate the progress of gene therapy.
Computed tomographic-angiographic findings within the first five hours of cerebral infarction. (1991)

We conclude that cerebral infarctions are often visible on early scans, but their locations may not be etiologically determinative. The infarcts associated with intracranial arterial occlusions (45%) were of thromboembolic origin, but, given current controversies as to the pathophysiology of lacunar and watershed infarctions, we cannot ascertain the etiology in the remainder. These findings are relevant to the new stroke therapies that require administration in the first hours after infarction.
SUSAN 3D operator, principal saliency degrees and directions extraction and a brief study on the robustness to noise (2009)

In order to complete the work on the 3D SUSAN operator, an extraction of principal saliency degrees and direction is proposed. This will lead the proposed operator to a complete classification of vertices in five different classes: cavity points, valley points, flat points, prong points and salient points. To assess the operator, we propose two different studies. The robustness to the resolution and the regularity of meshes is presented for three different operators. To complete the evaluation, the robustness to noise is analysed, for the Stokely and the SUSAN operator. Our conclusion presents the benefits, drawbacks of the technique and future works.
Distinction between Epstein-Barr virus type A (EBNA 2A) and type B (EBNA 2B) isolates extends to the EBNA 3 family of nuclear proteins (1989)

The Epstein-Barr virus (EBV) nuclear antigens EBNA 3a, 3b, and 3c have recently been mapped to adjacent reading frames in the BamHI L and E fragments of the B95.8 EBV genome. We studied by immunoblotting the expression of the family of EBNA 3 proteins in a panel of 20 EBV-transformed lymphoblastoid cell lines (LCLs) carrying either type A (EBNA 2A-encoding) or type B (EBNA 2B-encoding) virus isolates. Certain human sera from donors naturally infected with type A isolates detected the EBNA 3a, 3b, and 3c proteins in all type A virus-transformed LCLs (with a single exception in which EBNA 3b was not detected) but detected only EBNA 3a in LCLs carrying type B isolates. These results were confirmed with human and murine antibodies with specific reactivity against sequences of the type A EBNA 3a, 3b, or 3c expressed in bacterial fusion proteins. Conversely, selected human sera from donors naturally infected with type B strains of EBV identified the EBNA 3a encoded by both types of isolates plus two novel EBNAs present only in type B, and not in type A, virus-transformed LCLs; these novel proteins appear to be the type B homologs of EBNA 3b and 3c. The distinction between type A and type B EBV isolates therefore extends beyond the EBNA 2 gene to the EBNA 3 family of proteins. This has important implications with respect to the evolutionary origin of these two EBV types and also places in a new light recent studies which identified differences between type A and type B transformants in terms of growth phenotype (A. B. Rickinson, L. S. Young, and M. Rowe, J. Virol. 61:1310-1317, 1987) and of detection by EBV-specific cytotoxic T cells (D. J. Moss, I. S. Misko, S. R. Burrows, K. Burman, R. McCarthy, and T. B. Sculley, Nature [London] 331:719-721, 1988).
Robotically controlled slosh-free motion of an open container of liquid (2002)

This paper describes two methods for controlling the surface of a liquid in an open container as it is being carried by a robot arm. Both methods make use of the fundamental mode of oscillation and damping of the liquid in the container as predicted from a boundary element model of the fluid. The first method uses an infinite impulse response filter to alter an acceleration profile so that the liquid remains level except for a single wave at the beginning and end of the motion. The motion of the liquid is similar to that of a simple pendulum. The second method removes the remaining two surface oscillations by tilting the container parallel to the beginning and ending wave. A double pendulum model is used to determine the trajectory for this motion. Experimental results of a FANUC S-800 robot moving a 230 mm diameter hemispherical container of water are presented.
A new chromosomal abnormality in a patient with acute myelomonocytic leukemia (1983)

Abstract We report a 15‐month‐old boy with acute myelomonocytic leukemia [French‐American‐British classification M4 (FAB‐M4)] whose leukemic cells demonstrated a translocation 46,XY, t(9;11)(p24;q12) that has not been described previously.
Design and construction of a test bench to characterize efficiency and reliability of high voltage battery energy storage systems (2010)

Stationary battery energy storage systems are widely used for uninterruptible power supply systems. Furthermore, they are able to provide grid services. This yields in rising installed power and capacity. One possibility uses high voltage batteries. This results in an improvement of the overall system efficiency. High voltage batteries may be advantageous for future medium voltage DC-grids as well. In all cases, high availability and reliability is indispensable. Investigations on the operating behavior of such systems are needed. For this purpose, a test bench for high voltage storage systems was built to analyze these processes for different battery technologies. A special safety infrastructure for the test bench was developed due to the high voltage and the storable energy of approximately 120 kWh. This paper presents the layout of the test bench for analyzing high voltage batteries with about 4,300 volts including all components, the safety requirements with the resultant safety circuit and the aim of the investigations to be performed with the test bench.
A Multiple-Zone Cycle Simulation for Spark-Ignition Engines: Thermodynamic Details (2001)

Abstract A thermodynamic cycle simulation was developed for a spark-ignition engine which included the use of multiple zones for the combustion process. This simulation was used to complete analyses for a commercial, spark-ignition V-8 engine operating at a part load condition. Specifically, the engine possessed a compression ratio of 8.1:1, and had a bore and stroke of 101.6 and 88.4 mm, respectively. A part load operating condition at 1400 rpm with an equivalence ratio of 1.0 was examined. Results were obtained for overall engine performance, for detailed in-cylinder events, and for the thermodynamics of the individual processes. In particular, the characteristics of the engine operation with respect to the combustion process were examined. Implications of the multiple zones formulation for the combustion process are described.
ChemInform Abstract: ENZYME‐ACTIVATED IRREVERSIBLE INHIBITORS OF MONOAMINE OXIDASE: PHENYLALLYLAMINE STRUCTURE‐ACTIVITY RELATIONSHIPS (1985)

Abstract Auf den im Formelschema beschriebenen Wegen werden z.B. die Aryl‐allylamine (III), (V), (VI), (VIII) und (IX) dargestellt, deren Monoamin‐Oxidase‐inhibierende Wirkung geprüft wird.
Unusual vibrational dynamics of the acetic acid dimer (2001)

The vibrational relaxation of the C=O stretching mode of the CH3CO2H cyclic dimer, the CH3CO2D cyclic dimer, and CH3CO2CH3 were measured in CCl4 solution at room temperature. The population relaxation of the v=1 state of the C=O mode is nonexponential, modeled with a biexponential decay having a fast time constant in the subpicosecond regime and a slow time constant of a few picoseconds. For the cyclic dimers of the acetic acids, the fast component dominates the population decay, whereas the slow component dominates the decay of the CH3CO2CH3, the model compound for the monomeric acetic acid. Deuteration of the dimer increases the relaxation time constant. The non-hydrogen-bonding monomer methyl acetate also has a subpicosecond decay constant. The pump–probe anisotropy decay reveals that the orientational dynamics of these molecules also occurs on the subpicosecond time scale and is reasonably well described by rotational diffusion in the slip hydrodynamic limit. Stimulated infrared photon echo decay experiments reveal that the correlation function of the frequency fluctuations of the cyclic acid dimer has a motionally narrowed process described by a 4 ps pure dephasing time and process with a 2.1 ps correlation time, comparable to a solvent response time. The dephasing dynamics is dominated by the population relaxation. In analyzing the photon echo data, the contribution from the rotational diffusion is incorporated by approximating the cyclic acid dimer as a symmetric top diffuser with its transition dipole located in the molecular plane but not parallel to any of the principal axes. General formulas, which will be useful in other applications, for incorporation of the diffusive dynamics of the symmetric top into the third order response functions are obtained. Nonexponential fast vibrational relaxation of C–CO2–X moiety is not adequately described by the anharmonic coupling with the nearby combination and overtone bands. In the regime where the rotational, vibrational, and dephasing times are all comparable, the solvent memory effects may play a role in vibrational dynamics, causing unusually rapid nonexponential population decay.
Low-temperature formation of epitaxial graphene on 6H-SiC induced by continuous electron beam irradiation (2012)

It is observed that epitaxial graphene forms on the surface of a 6H-SiC substrate by irradiating electron beam directly on the sample surface in high vacuum at relatively low temperature (∼670 °C). The symmetric shape and full width at half maximum of 2D peak in the Raman spectra indicate that the formed epitaxial graphene is turbostratic. The gradual change of the Raman spectra with electron beam irradiation time increasing suggests that randomly distributed small grains of epitaxial graphene form first and grow laterally to cover the entire irradiated area. The sheet resistance of epitaxial graphene film is measured to be ∼6.7 kΩ/sq.
Unequal power control in ATM/CDMA wireless communication networks (2002)

The concept of "unequal power control" is proposed to meet the need of integrated traffic transmission in ATM/CDMA wireless communication networks. By "unequal power control" we mean that power control in the reverse channels is such that the signal power received at the receiver be unequal for different kinds of traffic while being equal for the same kind of traffic. "Unequal power control" in the case of single traffic becomes the power control in the current CDMA cellular networks (i.e., equal power control). Using voice/data integrated traffic as an example, a detailed analysis of the optimum power factor, the throughput and capacity of the reverse channels in the case of unequal power control and the comparison with the equal power control case are both presented. The results show that unequal power control can expand the allowable load area and provide a significant improvement in the system capacity comparing with equal power control.
Design and Performance Evaluation of a Multi-Purpose HTS DC Induction Heating Machine for Industrial Applications (2014)

In general, conventional induction heating system is designed only for a specific metal billet or object, because the heating system should be specialized to guarantee the best performance regarding heating quality and efficiency. It has been applied to large heating systems in metallic processing industries. A DC induction heating method using HTS magnets can be one of the better counterplans for higher efficiency and multi-purpose heating system. In this paper, we evaluated a performance of a 10 kW-class multi-purpose HTS DC induction heating machine without additional function or equipment, and performed efficiency analysis on various metals, including aluminum, copper, and iron billets. In addition, heating characteristics of other materials were simulated and analyzed through finite elements method (F.E.M.) models. The results demonstrate that the 2G HTS DC induction heating machine is applicable for all the ferrous and nonferrous metals and useful for large scale industrial applications.
Data from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Sustained minimal residual disease (MRD) negativity is associated with long-term survival in multiple myeloma. The gut microbiome is affected by diet, and in turn can modulate host immunity, for example through production of short-chain fatty acids including butyrate. We hypothesized that dietary factors affect the microbiome (abundance of butyrate-producing bacteria or stool butyrate concentration) and may be associated with multiple myeloma outcomes.&lt;/p&gt;Experimental Design:&lt;p&gt;We examined the relationship of dietary factors (via a food frequency questionnaire), stool metabolites (via gas chromatography–mass spectrometry), and the stool microbiome (via 16S sequencing - α-diversity and relative abundance of butyrate-producing bacteria) with sustained MRD negativity (via flow cytometry at two timepoints 1 year apart) in myeloma patients on lenalidomide maintenance. The Healthy Eating Index 2015 score and flavonoid nutrient values were calculated from the food frequency questionnaire. The Wilcoxon rank sum test was used to evaluate associations with two-sided &lt;i&gt;P&lt;/i&gt; &lt; 0.05 considered significant.&lt;/p&gt;Results:&lt;p&gt;At 3 months, higher stool butyrate concentration (&lt;i&gt;P&lt;/i&gt; = 0.037), butyrate producers (&lt;i&gt;P&lt;/i&gt; = 0.025), and α-diversity (&lt;i&gt;P&lt;/i&gt; = 0.0035) were associated with sustained MRD negativity. Healthier dietary proteins, (from seafood and plants), correlated with butyrate at 3 months (&lt;i&gt;P&lt;/i&gt; = 0.009) and sustained MRD negativity (&lt;i&gt;P&lt;/i&gt; = 0.05). Consumption of dietary flavonoids, plant nutrients with antioxidant effects, correlated with stool butyrate concentration (anthocyanidins &lt;i&gt;P&lt;/i&gt; = 0.01, flavones &lt;i&gt;P&lt;/i&gt; = 0.01, and flavanols &lt;i&gt;P&lt;/i&gt; = 0.02).&lt;/p&gt;Conclusions:&lt;p&gt;This is the first study to demonstrate an association between a plant-based dietary pattern, stool butyrate production, and sustained MRD negativity in multiple myeloma, providing rationale to evaluate a prospective dietary intervention.&lt;/p&gt;&lt;/div&gt;
Superpixel based unsupervised change detection of manmade targets on satellite images (2015)

In this paper, a novel solution to the problem of change detection in bitemporal satellite images is presented. The approach can be described as 1) Preprocessing, in which both images' luminance levels are approximated to the same distribution via the Contrast Limited Adaptive Histogram Equalization (CLAHE) algorithm and noise is filtered out by the use of a Bilateral Noise Reduction (BNR) filter; 2) Extraction of a joint superpixel map of both images using a novel method; 3) Calculation of a variety of metrics at the superpixel level that are directed towards finding man-made changes; 4) Calculating a final change mask from a final difference image via thresholding. The proposed method is tested on bitemporal images of a number of urban regions.
The influence of net community production and phytoplankton community structure on CO2 uptake in the Gulf of Alaska (2013)

Abstract Biological productivity is a key factor controlling the ocean's ability to take up carbon dioxide from the atmosphere. However, the ecological dynamics that drive regions of intense productivity and carbon export are poorly understood. In this study, we present high‐spatial‐resolution estimates of air‐sea CO 2 flux, net community production (NCP) rates calculated from O 2 /Ar ratios, and phytoplankton population abundances determined by continuous underway measurements on a cruise across the Gulf of Alaska in May 2010. The highest rates of NCP (79.2 ± 13 mmol C m ‐2 d ‐1 ) and oceanic CO 2 uptake (air‐sea flux of −14.7 ± 2.4 mmol C m ‐2 d ‐1 ) were observed across a transition zone between the high‐nitrate low‐chlorophyll (HNLC) waters of the Alaskan Gyre and the coastal waters off the Aleutian Islands. While the transition zone comprises 20% of the total area covered in crossing the Gulf of Alaska, it contributed 49% of the total NCP and 48% of the total CO 2 uptake observed along the cruise track. A corresponding transition zone phytoplankton bloom was dominated by two small‐celled (&lt;20 µm) phytoplankton communities, which were distinct from the phytoplankton communities in the surrounding Alaskan Gyre and coastal waters. We hypothesize that mixing between iron‐rich coastal waters and iron‐limited Alaskan Gyre waters stimulated this bloom and fueled the high NCP and CO 2 export observed in the region.
Correction: FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ (2011)

Nimustine (ACNU) and temozolomide (TMZ) are DNA alkylating agents which are commonly used in chemotherapy for glioblastomas. ACNU is a DNA cross-linking agent and TMZ is a methylating agent. The therapeutic efficacy of these agents is limited by the development of resistance. In this work, the role of the Fanconi anemia (FA) repair pathway for DNA damage induced by ACNU or TMZ was examined. Cultured mouse embryonic fibroblasts were used: FANCA 2/2 , FANCC 2/2 , FANCA 2/2 C 2/2 , FANCD2 2/2 cells and their parental cells, and Chinese hamster ovary and lung fibroblast cells were used: FANCD1/BRCA2mt, FANCG 2/2 and their parental cells. Cell survival was examined after a 3 h ACNU or TMZ treatment by using colony formation assays. All FA repair pathways were involved in ACNU-induced DNA damage. However, FANCG and FANCD1/BRCA2 played notably important roles in the repair of TMZ-induced DNA damage. The most effective molecular target correlating with cellular sensitivity to both ACNU and TMZ was FANCD1/BRCA2. In addition, it was found that FANCD1/BRCA2 small interference RNA efficiently enhanced cellular sensitivity toward ACNU and TMZ in human glioblastoma A172 cells. These findings suggest that the down-regulation of FANCD1/BRCA2 might be an effective strategy to increase cellular chemo-sensitization towards ACNU and TMZ.
Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain (2019)

Mirror therapy (MT) has been proposed as an effective rehabilitative strategy to alleviate pain symptoms in amputees with phantom limb pain (PLP). However, establishing the neural correlates associated with MT therapy have been challenging given that it is difficult to administer the therapy effectively within a magnetic resonance imaging (MRI) scanner environment. To characterize the functional organization of cortical regions associated with this rehabilitative strategy, we have developed a combined behavioral and functional neuroimaging protocol that can be applied in participants with a leg amputation. This novel approach allows participants to undergo MT within the MRI scanner environment by viewing real-time video images captured by a camera. The images are viewed by the participant through a system of mirrors and a monitor that the participant views while lying on the scanner bed. In this manner, functional changes in cortical areas of interest (e.g., sensorimotor cortex) can be characterized in response to the direct application of MT.
Carbon-13 Magnetic Resonance. III.1 Purine (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-13 Magnetic Resonance. III.1 PurineRonald J. Pugmire, David M. Grant, Roland K. Robins, and George W. RhodesCite this: J. Am. Chem. Soc. 1965, 87, 10, 2225–2228Publication Date (Print):May 1, 1965Publication History Published online1 May 2002Published inissue 1 May 1965https://pubs.acs.org/doi/10.1021/ja01088a023https://doi.org/10.1021/ja01088a023research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts