gebhart/patrepeval huggingface dataset:
Revista iberoamericanas de comunicación (1999)

Los editores de revistas tericas internacionales especializadas en comunicacin y cultura de masas responden a unos patrones que suelen repetirse entre unos pases y otros.El abanico de posibilidades no es muy amplio, ya que generalmente va desde las universidades y centros de investigacin hasta las asociaciones profesionales y acadmicas, pasando por las fundaciones pblicas o empresas comerciales y organismos de la Administracin.En general, se trata de un tipo de publicaciones con una tirada reducida, con escasos suscriptores o intercambios con otras revistas similares, habitualmente con formato de libro y con un coste de produccin no muy elevado.En la mayora de los casos no cuentan con publicidad comercial y, por tanto, las fuentes de financiacin son escasas: bien las sufraga en su totalidad la propia institucin editora o deben recurrir a subvenciones pblicas y al patrocinio de grandes empresas.El mercado anglosajn (especialmente los
Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss (2014)

The weight maintaining effect of GLP-1RAs may be mediated by smaller decrease in free leptin and higher PYY3-36 response. Low dose GLP-1RA therapy maintained 12% weight loss for 1 year and may prevent pre-diabetes in obesity.
Radiosynthesis of a potent endothelin receptor antagonist: [11C] L‐753,037 (2000)

[11C]-L-753,037, [(+)-(5S,6R,7R)-2-butyl-7-[2-((2S)-2-carboxypropyl)-4-[11C]-methoxyphenyl]-5-(3,4-methylenedioxyphenyl)-cyclopenteno-[1,2-b]pyridine-6-carboxylate], a potent mixed antagonist of endothelin receptor subtypes ETA and ETB, was synthesized by [11C]-methylation of a phenolic precursor. The time for synthesis, purification, and formulation was 17 minutes with an average specific radioactivity of 2535 mCi/µmol (EOS) and average decay corrected radiochemical yield of 3% based on [11C]-methyl iodide. Copyright © 2000 John Wiley & Sons, Ltd.
Incremental Few-Shot Object Detection for Robotics (2022)

Incremental few-shot learning is highly expected for practical robotics applications. On one hand, robot is desired to learn new tasks quickly and flexibly using only few annotated training samples; on the other hand, such new additional tasks should be learned in a continuous and incremental manner without forgetting the previous learned knowledge dramatically. In this work, we propose a novel Class-Incremental Few- Shot Object Detection (CI-FSOD) framework that enables deep object detection network to perform effective continual learning from just few-shot samples without re-accessing the previous training data. We achieve this by equipping the widely-used Faster-RCNN detector with three elegant components. Firstly, to best preserve performance on the pre-trained base classes, we propose a novel Dual-Embedding-Space (DES) architecture which decouples the representation learning of base and novel categories into different spaces. Secondly, to mitigate the catastrophic forgetting on the accumulated novel classes, we propose a Sequential Model Fusion (SMF) method, which is able to achieve long-term memory without additional storage cost. Thirdly, to promote inter-task class separation in feature space, we propose a novel regularization technique that extends the classification boundary further away from the previous classes to avoid misclassification. Overall, our framework is simple yet effective and outperforms the previous SOTA with a significant margin of 2.4 points in AP performance.
A two-dimensional, finite-element, flux-corrected transport algorithm for the solution of gas discharge problems (2000)

An improved finite-element flux-corrected transport (FE-FCT) scheme, which was demonstrated in one dimension by the authors, is now extended to two dimensions and applied to gas discharge problems. The low-order positive ripple-free scheme, required to produce a FCT algorithm, is obtained by introducing diffusion to the high-order scheme (two-step Taylor-Galerkin). A self-adjusting variable diffusion coefficient is introduced, which reduces the high-order scheme to the equivalent of the upwind difference scheme, but without the complexities of an upwind scheme in a finite-element setting. Results are presented which show that the high-order scheme reduces to the equivalent of upwinding when the new diffusion coefficient is used. The proposed FCT scheme is shown to give similar results in comparison to a finite-difference time-split FCT code developed by Boris and Book. Finally, the new method is applied for the first time to a streamer propagation problem in its two-dimensional form.
A new technique for audio packet loss concealment (2002)

We present a new error concealment technique for audio transmission over heterogeneous packet switched networks based on time-scale modification of correctly received packets. An appropriate time-scale modification algorithm, WSOLA ("Waveform Similarity Overlap-Add"), is used and its parameters are optimized for scaling short audio segments. Particular attention is paid to the additional delay introduced by the new technique. For subjective listening tests, packet loss is simulated at error rates of 20% and 33% and the new technique is compared to previous proposals by category and component judgment of speech quality. The test results show that typical disturbance components of other techniques can be avoided and overall sound quality is higher.
Identification of a Dynamic Core Transcriptional Network in t(8;21) AML Regulating Differentiation Block and Self-Renewal (2014)

Abstract One of the best-characterized chromosomal rearrangements found in AML is the t(8;21) translocation which accounts for approximately 10% of all AMLs and fuses the DNA-binding domain of the hematopoietic master regulator RUNX1 to the almost the entire ETO protein. The resulting RUNX1/ETO fusion protein lacks the transactivation domain of RUNX1 resulting in major differences in the biological activities of RUNX1 and RUNX1/ETO. RUNX1 normally recruits transcriptional activators and binds to DNA as a heterodimer with CBFb which is important for high-affinity DNA binding. The RUNX1/ETO fusion protein also interacts with CBFb but functions as a RUNX1/ETO tetramer, and like ETO itself, it also interacts with NCOR and SIN3A co-repressors. The leukemogenic fusion protein RUNX1/ETO forms a complex with other transcription factors and the binding of this complex to RUNX1 target genes causes a block in myeloid differentiation. Here we investigate the dynamic changes in global transcription factor binding patterns that occur immediately following depletion of RUNX1/ETO. To that end, we combined digital footprinting, ChIP-sequencing for multiple factors and transcriptome analysis to identify the core transcriptional network of t(8;21) AML cells, and then characterized changes in these networks upon RUNX1/ETO knockdown. These analyses revealed a dynamic equilibrium between RUNX1/ETO and RUNX1 complexes competing for the same genomic sites. We show by sequential ChIP that both complexes have similar transcription factor compositions, but differ in their preference for the recruitment of co-activators and co-repressors. Using a novel digital DNaseI footprinting approach we show that both t(8;21)-positive cell lines and patient-derived primary AML cells share the same pattern of binding site occupancy. Within this core transcriptional network, RUNX1/ETO-bound loci are predominantly associated with gene repression. Furthermore, loss of RUNX1/ETO establishes a new differentiation-associated transcriptional network dominated by de novo binding of C/EBPa resulting from the up-regulation of CEBPA gene expression. Our results demonstrate that the block in myeloid differentiation in t(8;21) is caused by the dynamic interference of RUNX1/ETO with cis-regulatory elements destined to bind alternate factor assemblies during myeloid differentiation including both RUNX1 and C/EBPa. Disclosures No relevant conflicts of interest to declare.
Q-switched frequency-doubled Nd:YAG laser surface finishing of metals (1983)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Clifton W. Draper and Albert Holliday, "Q-switched frequency-doubled Nd:YAG laser surface finishing of metals," Appl. Opt. 22, 2521-2522 (1983) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Study of Operation Accuracy on Cooperative Work in Spherical Displays. (2004)

Various virtual reality systems on the basis of 3-dimensional computer graphics have been researched. Applications involving two or more persons cooperating work were made for an experiment. In cooperative work in virtual space, communication and a high of reality are important. However, this research did not consider evaluating the operation accuracy of cooperative work in virtual space. Therefore, we built the functionto evaluate the operation accuracy of cooperative work in spherical displays, and we examined the operation accuracy using an experiment.
Esterase distribution in the rabbit cornea and its implications in ocular drug bioavailability (1982)

Being the major pathway by which topically applied ophthalmic drugs enter the eye, the cornea can control the amount of active drug ultimately absorbed by offering resistance to drug permeation and by metabolizing the drug during permeation. This research seeks to determine the esterase activity in the cornea and two of its component layers--epithelium and stroma-endothelium--so as to anticipate the extent to which drugs containing ester linkages will be metabolized during transport. This has been achieved by incubating corneal homogenates of albino and pigmented rabbits of various age groups with alpha-naphthyl acetate, the model substrate, and monitoring the fluorescence intensity due to alpha-naphthol as a function of time. The results indicate that: (1) esterase activity in the epithelium is approximately twice that in the stroma-endothelium; (2) esterase activity in the intact cornea is linearly related to those in the epithelium and the stroma-endothelium; and (3) the esterase activity in the cornea and its component layers varies with rabbit's age and strain. According to these results the bulk of esterase-mediated hydrolysis is expected to take place in the epithelium, so that the residence time of a drug in this tissue can have a significant impact on its ocular bioavailability.
Could Alkali Production Be Considered an Approach for Caries Control? (2010)

This study investigated the relationship of arginine deiminase (ADS) and urease activities with dental caries through a case-control study. ADS and urease activities were measured in dental smooth-surface supragingival plaque and whole saliva samples from 93 subjects, who were in three different groups: caries-free (n = 31), caries-active (n = 30), and caries-experienced (n = 32). ADS activity was measured by quantification of the ammonia generated from the incubation of plaque and saliva samples in a mixture containing 50 mM arginine-HCl and 50 mM Tris-maleate buffer, pH 6.0. ADS-specific activity was defined as nanomoles of ammonia generated per minute per milligram of protein. Urease activity was determined by quantification of ammonia produced from 50 mM urea. For bacterial identification and enumeration real-time qPCR analysis was used. Groups were compared using Kruskal-Wallis tests. Spearman correlations were used to analyze plaque metabolic activity and bacterial relationships. The results revealed significantly higher ammonia production from arginine in saliva (1.06 vs. 0.18; p < 0.0001) and plaque samples (1.74 vs. 0.58; p < 0.0001) from caries-free subjects compared to caries-active subjects. Urease levels were about 3-fold higher in the plaque of caries-free subjects (p < 0.0001). Although higher urease activity in saliva of caries-experienced and caries-free subjects was evident, no significant difference was found between the groups.
Evaluation of Time Resolution and Comparison of Modern Silicon Photomultipliers (2018)

The timing performance of silicon photomultipliers (SiPMs) is of great interest for a variety of different detection systems. Numerous studies have attempted to optimize and characterize the timing resolution of various SiPMs, usually incorporating significant front-end electronics to maximize this quantity, showing timing capability with SiPMs on the order of 100 ps. With the growth in popularity of SiPMs, many options exist on the market. This work aims to assess and compare the different SiPMs available with minimal analog signal processing to test the coincidence time resolution achievable with straightforward setup, and to see which SiPMs and which SiPM characteristics (i.e. microcell size) intrinsically lend themselves to superior time resolution. Both LYSO and p-terphenyl scintillators are used, and coincidence time resolution is assessed at multiple temperatures. With SiPMs, the p-terphenyl yields superior time resolution down to 222 ps, compared to 348 ps with LYSO. Little evidence for improvement of timing with reduced temperature down to -10 °C is observed. Two fast Hamamatsu H10580 photomultiplier tubes are also used to compare the time resolution with and are found to have even better time resolution, below 100 ps.
Space-frequency coded OFDM system for multi-wire power line communications (2005)

In this paper, we propose an efficient space-frequency coded orthogonal frequency-division multiplexing (OFDM) system for high-speed data transmission over frequency selective multi-wire power line channels. By transmitting the same data symbol over two uncoupled pair of wires and over two different carriers, with a frequency separation between carriers greater than the coherence bandwidth of the channel, the proposed scheme extracts both space and frequency diversity in the absence of channel knowledge at the transmitter. Numerical results are provided to demonstrate the significant performance improvement obtained by the proposed scheme over conventional single-wire OFDM systems when the frequency selective power line channel is corrupted by impulsive noise.
The effects of non-steroidal anti-inflammatory drug application on incisional wound healing in rats (2007)

We recommend short-term diclofenac application for post-surgical and post-traumatic patients with wounds who would benefit from its antiphlogistic and analgesic effect. However, if wound healing is disturbed, the negative effect of diclofenac on fibroblasts should be considered. This is particularly relevant for patients with chronic wounds or conditions such as diabetes which can delay wound healing.
CW operation of 1.55-μm bipolar cascade laser with record differential efficiency, low threshold, and 50-/spl Omega/ matching (2003)

By electrically segmenting an InP ridge laser and series-connecting the segments, we have created the first highly scalable bipolar cascade lasers. We report room-temperature continuous-wave operation of 12-stage lasers with a record 390% differential efficiency and 2.8-mA threshold, as well as three-stage lasers with 50-/spl Omega/ input impedance and 118% efficiency.
Recent Progress in Droplet-Based Manufacturing Research (2002)

This article reports the recent progress of re-search made in the Droplet-Based Manufacturing Laboratory at MIT. The study has been focused on obtaining a fundamental understanding of microdroplet deposition and applying the technology to various practical applications. Specific scientific contributions include the development of an analytical model for droplet splashing/recoiling, an in situ droplet size control methodology, and a study of microstructure design for spray forming. The research per-formed in the lab provides both fundamental knowledge base and practical process developments for a range of manufacturing applications, including electronics packaging, spray forming and freeform fabrication.
Development of a New Lateral Flow Assay Based on IBMP‐8.1 and IBMP‐8.4 Chimeric Antigens to Diagnose Chagas Disease (2020)

Despite several available methodologies for Chagas disease (CD) serological screening, the main limitation of chronic CD diagnosis is the lack of effective tools for large-scale screening and point-of-care diagnosis to be used in different CD epidemiological scenarios. Taking into account that developing such a diagnostic tool will significantly improve the ability to identify CD carriers, we aimed at performing a proof-of-concept study (phase I study) to assess the use of these proteins in a point-of-care platform using serum samples from different geographical settings of Brazil and distinct clinical presentations. The diagnostic accuracy study was conducted on a panel of two WHO International Standards (IS) and 14 sera from <i>T. cruzi</i>-positive and 16 from <i>T. cruzi</i>-negative individuals. The results obtained with the test strips were converted to digital images, allowing quantitative comparison expressed as a relative band intensity ratio (RBI). The diagnostic potential and performance were also determined. Regardless of the geographical origin or clinical presentation, all sera with <i>T. cruzi</i> antibodies returned positive both for IBMP-8.1 and IBMP-8.4 chimeric antigens. The area under the ROC curve (AUC) values was 100% for both antigens, demonstrating an outstanding overall diagnostic accuracy (100%). Based on the data, we believe that the lateral flow assays based on these antigens are promising methodologies for screening CD.
Hybrid Membrane-based Ionic Liquid Absorption Cycle for Water Heating, Dehumidification, and Cooling (2023)

To meet the growing energy consumption and mitigate climate concerns, novel energy efficient technologies need to be developed. Water heating, dehumidification and space cooling form a significant percentage (~24%) of a typical U.S. household energy consumption and a total of 2.6 quad of primary energy consumption. In this paper, we present a novel system for combined water heating, dehumidification, and space cooling. The three processes can be achieved by one device using a novel semi-open absorption based system combined with evaporative cooling. The absorption based system absorbs water vapor from its ambient. The latent heat of absorption, released into the absorbent, is transferred into the process water that cools the absorbent. The water absorbed is later released in the desorber through heating, and the water vapor generated in the desorber is condensed and its heat of phase change is transferred to the process water in the condenser. The condensed water vapor can either be drained if dehumidification is desired or be used in an evaporative cooling process for space cooling. The major innovations that enable such an absorption-based device are demonstrated in this study through an experimental test setup. First, a membrane based absorption system in a compact and scalable platform is used to alleviate the liquid entrainment issue encountered in the conventional packed bed absorbers. Second, architecture reconfigurations, like novel fluid circuits and semi-open absorption system are deployed to enhance performance and lower system cost. Finally, an ionic liquid is implemented to minimize corrosion and eliminate crystallization risks, a major concern with conventional salts. The water heating and dehumidification component of the device are experimentally evaluated and the device is characterized for various system parameters. A water heating COP of 1.4 is achieved in this first generation prototype. These innovations pave the way for a compact, efficient, and low cost absorption based system for residential scale applications.
台灣閩南語「遘」的語法化和詞彙化 (2015)

Researchers of grammaticalization have often suggested that decategorialization can be manifested as a cline of categoriality, statable as: major category (>intermediate category) > minor category (Hopper and Traugott 2003: 107). Previous studies investigated the full schema from a variety of perspectives and considerable concerns have arisen over the semantic and syntactic behavior, which yield fruitful results (Heine and Kuteva 2002). However, researches which have documented the fragmented schema, major category > minor category and major category >intermediate category, are scant. Therefore, the aim of this thesis attempts to discuss kau3 as an intriguing word showing the phenomenon of the fragmented schema in Taiwanese Southern Min (henceforth TSM). Kau3 can be classified into five main groups. To start with, kau3 is a main verb ‘arrive’. Next, kau3 is a preposition ‘at’, and ‘to’. Next, kau3 is a complement meaning ‘enough’. Next, kau3 is an adjective ‘enough’. Lastly, kau3 is an adverb ‘enough’, as well. The last two kau3 denoting enough mostly follows u7 ‘have’ or bo5 ‘not have’ successively. Put differently, the last two uses of kau3 are complement in semantic aspect, but kau3 gets lexicalized with verb in syntactic frame into an adjective and an adverb. The research involves reviewing the corpora that comprise the early and modern SM data. Early Southern Min data include nine SM playscripts and Go En; modern Southern Min data includes SM story series compiled by Hu Wan Chuan et al, and transcripts of SM soap operas. The analysis of this study was based on grammaticalization to indicate the relationship between the five sets of categories kau3. Result of this study shows the grammaticalization paths of the five sets of categories kau3. To conclude, this paper may be of importance to account for the dynamic relationship between the five sets of categories kau3, and providing researchers with a better understanding of how the meaning about kau3 is related to its grammaticalization paths and distribution.
Basics for Improved Use of Phages for Therapy (2021)

Blood-borne therapeutic phages and phage capsids increasingly reach therapeutic targets as they acquire more persistence, i.e., become more resistant to non-targeted removal from blood. Pathogenic bacteria are targets during classical phage therapy. Metastatic tumors are potential future targets, during use of drug delivery vehicles (DDVs) that are phage derived. Phage therapy has, to date, only sometimes been successful. One cause of failure is low phage persistence. A three-step strategy for increasing persistence is to increase (1) the speed of lytic phage isolation, (2) the diversity of phages isolated, and (3) the effectiveness and speed of screening phages for high persistence. The importance of high persistence-screening is illustrated by our finding here of persistence dramatically higher for coliphage T3 than for its relative, coliphage T7, in murine blood. Coliphage T4 is more persistent, long-term than T3. <i>Pseudomonas chlororaphis</i> phage 201phi2-1 has relatively low persistence. These data are obtained with phages co-inoculated and separately assayed. In addition, highly persistent phage T3 undergoes dispersal to several murine organs and displays tumor tropism in epithelial tissue (xenografted human oral squamous cell carcinoma). Dispersal is an asset for phage therapy, but a liability for phage-based DDVs. We propose increased focus on phage persistence-and dispersal-screening.