gebhart/patrepeval huggingface dataset:
Hydrodynamic Characteristics of Porcine Aortic Valves Cross-Linked With Glutaraldehyde and Polyepoxy Compounds (2008)

Porcine aortic valve (AoF) tissues cross-linked with glutaraldehyde and epoxy compounds were reported to have high anticalcification properties, but their hydrodynamic characteristics have not been evaluated. The aim of the present study was to investigate the hydrodynamic differences between porcine AoFs, cross-linked with concomitant use of an epoxy compound and glutaraldehyde, at different fixation periods. The valves were mounted on a pulsatile flow circulation mimicking a left heart. The left atrial and left ventricular pressures and mitral and aortic flows were measured at every 0.002 seconds, and the hydrodynamic factor of the valves mounted on the mitral position was estimated. Effective orifice area and the regurgitation volume, which are used as indicators of valve efficiency, failed to detect significant differences due to glutaraldehyde fixation time. In addition, the pressure gradient across the bioprosthetic valve and the variation of mitral flow also had no significant differences. The flow circuit model of the present study was mimicking of a left heart. The evaluation of the mitral valvular function with different glutaraldehyde fixation times was accomplished by relating the pressure with the flow, and by estimating the time lag between valve motion and transvalvular flow.
Ventricular arrhythmia susceptibility in a new porcine model of heart failure (HF) with reduced ejection fraction (2021)

Abstract Introduction Sudden death secondary to ventricular arrhythmias is common in HF patients, with no effective treatment available outside of implantable cardiac defibrillators. While animal models are essential for the discovery of anti-arrhythmic drugs, no reliable large animal HF models with associated ventricular arrhythmias have been described so far. Objectives We aimed at evaluating ventricular remodeling and arrhythmia susceptibility in an HF pig model with reduced ejection fraction (EF) following myocardial infarction (MI). Methods MI was induced in 53 male Göttingen minipigs (12–15 months, 20–25 kg) by coronary embolization in mid-left anterior descending and mid-left circumflex coronary arteries using endovascular coils. Seven other pigs underwent sham operation and were used as control. Two weeks after surgery, cardiac function was assessed by echocardiography, and animals were included based on EF&amp;lt;50% (n=15/53), assigned either to 12 weeks of vehicle (n=9) or perindopril (n=6, 1 mg/kg/d, per os) group. At the end of the study, their left ventricular (LV) electrical remodeling was studied by echocardiography/electrocardiography and a programmed-electrical stimulation protocol was performed to evaluate the susceptibility to develop ventricular arrhythmias. Results At the end of the study, animals in the vehicle group had a significant LV remodeling associated with a reduced EF (p&amp;lt;0.05 vs. sham, see table). This remodeling was associated with cardio-pulmonary congestion, significant increases in LV end-diastolic pressure, left atrial volume, and lung mass (all p&amp;lt;0.05 vs. sham, see table), fully prevented by perindopril treatment. They had also an electrical remodeling as evidenced by an increase in PR, QRS, and QTc intervals, as well as LV effective refractory period (+18%, 14%, 33%, and 13%, respectively, p&amp;lt;0.05, compared to sham animals). Electrical changes were mitigated by perindopril treatment (p=NS vs. sham). LV mechanical dispersion measured with speckle-tracking echocardiography was significantly increased in vehicle group (58±5 vs. 22±1 ms in sham group, respectively) as well as in perindopril group. Programmed-electrical stimulations induced in 6/8 vehicle animals either non-sustained (n=3) or sustained (n=2) ventricular tachycardia, or ventricular fibrillation (n=1). In sham group only 1/7 animal had a ventricular fibrillation. No inducible ventricular arrhythmia was observed in animals treated with Perindopril. Conclusion In this new pig model of congestive HF with reduced EF, LV remodeling was associated with electrical remodeling and susceptibility to develop arrhythmias. Chronic angiotensin-converting enzyme inhibitor treatment prevented congestion, mitigated electrical remodeling, and suppressed arrhythmia susceptibility. Funding Acknowledgement Type of funding sources: Private company. Main funding source(s): Servier Research Institute - CardioVascular &amp; Metabolic Diseases Center for Therapeutic Innovation Table 1
The Anti-proliferative and Anti-bacterial Activity of Argan oil and Crude Saponin Extract from Argania spinosa (L.) Skeels (2019)

Introduction: Argan oil is a well-known cosmeceutical that is commercially available. It is traditionally used for the treatment of acne and skin inflammation among others. The objective of this study was to assess the anti-proliferative and antibacterial activities of argan oil and a crude saponin extract from the argan tree (Argania spinosa (L.) Skeels) that is endemic to Morocco. Materials and Methods: The anti-proliferative activity of argan oil and the crude saponin extract was assessed by the 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay on A431; HaCat; HeLa; MCF-7 and UCT-Mel 1 cells. The antibacterial activity was evaluated by the broth microdilution method against two species of bacteria: Cutibacterium acnes and Prevotella intermedia. Results: The results of this study indicated that the argan oil sample did not inhibit the cell growth of the specified cell lines up to 1000g/ml, while the crude saponin extract had low anti-proliferative activity. The minimal inhibitory concentration (MIC) values for both the argan oil and the crude saponin extract were found to be 500g/ml against Cutibacterium acnes. No antibacterial activity from the argan oil or the crude saponin extract was evident against Prevotella intermedia up to a concentration of 12.5mg/ml. Conclusion: The results of this study indicated that argan oil and the crude saponin extract might have direct inhibitory effects on the growth and proliferation of Cutibacterium acnes. This finding supports the use argan oil as a treatment for acne vulgaris.
A Comprehensive Study of Total Ionizing Dose Effect on the Electrical Performance of the GaN MIS-HEMT (2022)

In this work, the effect of Total Ionizing Dose (TID) on the performance of GaN on Si MIS-HEMT power devices with in-situ SiN cap layer is investigated. 13 samples were exposed to different accumulated dose (100 krad and 400 krad) of Co <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$^{60}~\gamma $ </tex-math></inline-formula> -ray irradiation with two bias conditions (grounded and stressed). The characteristics of the devices after irradiation experiment were evaluated by measuring V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> shift, on-resistance (R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> ), and dynamic R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> . A comprehensive study of TID effects are demonstrated in this article to verify different mechanisms and their interactions. Simulations using PHITs were also carried out to further confirm the damages in the epitaxial structure by the accumulated dose.
Comparison of Five Models to Scale Daily Evapotranspiration from One-Time-of-Day Measurements (2005)

Calculation of regional, spatially distributed evapotranspiration (ET) is possible usingremotely sensed surface temperatures from sensors aboard air or space platforms. These platformsprovide instantaneous data at frequencies of days to weeks, so that instantaneous latent heat fluxcan be computed from energy balance algorithms. However, instantaneous latent heat flux must beconverted to ET and then scaled to daily (24-h) totals for most practical applications. We comparedfive scaling models where a single measurement of 0.5-h ET was used to estimate the daily total.Each model takes advantage of the quasi-sinusoidal nature of daytime ET and other daytimeparameters including solar radiation, available energy, or reference ET. The surfaces were fullyirrigated alfalfa, partially irrigated cotton, dryland grain sorghum, and bare soil (tilled fallow sorghum).Actual ET was measured by precision weighing lysimeters. For cropped surfaces, the models basedon grass reference ET resulted in the best agreement between observed and predicted daily ETtotals. For bare soil, the model based on available energy (i.e., evaporative fraction) resulted in thebest agreement. Relative error between observed and predicted daily ET increased as daily ETdecreased. Observed and predicted daily ET agreed well for the transpiring crops (RMSE of 0.33 to0.46 mm d-1 for mean daily ET of 3.9 to 5.8 mm d-1) but poorly for bare soil (RMSE of 0.47 mm d-1 formean daily ET of 1.4 mm d-1).
Constrained Geometry Chromium Catalysts for Olefin Polymerization (1996)

Chromium(III) alkyls featuring an amido ligand tethered to a permethylcyclopentadienyl ring (i.e. [η5-Me4C5SiMe2-η1-NtBu]CrR) have been prepared and structurally characterized. They catalyze the polymerization of ethylene and the dimerization and isomerization of α-olefins.
Rescue from granzyme B-induced apoptosis by Wee1 kinase. (1995)

Granzymes are a family of granule-associated serine esterases that mediate apoptosis by cytotoxic T lymphocytes and natural killer cells. We have previously shown that cdc2, the mitosis-regulating cyclin-dependent kinase, is required for granzyme B-induced apoptosis in target cells. In addition, granzyme B induces premature activation and tyrosine dephosphorylation of cdc2 during apoptosis. Throughout most of the cell cycle and until the cell is prepared to enter mitosis, cdc2 kinase activity is negatively regulated by phosphorylation of a residue within its adenosine triphosphate-binding domain by Wee1, a nuclear kinase that maintains mitotic timing in eukaryotic cells. We have transiently expressed c-myc epitope-tagged Wee1 cDNA in BHK cells. Cells that expressed Wee1 in the nucleus became resistant to apoptosis induced by granzyme B and perforin. Wee1-transfected cells also exhibited markedly increased cdc2 tyrosine phosphorylation. Thus, Wee1 can rescue cells from granzyme-induced apoptosis by preventing cdc2 dephosphorylation.
High-Risk Human Papillomavirus Detection in Women With Low-Grade Squamous Intraepithelial Lesions or Higher-Grade Cytology Using the Cervista HPV HR Test (2012)

Detection of HR-HPV in women with LSIL or higher-grade cytology using the HPV HR test may allow clinicians to further triage women for advanced clinical management.
Delineating Noncovalent Interactions between the Azinomycins and Double-Stranded DNA:  Importance of the Naphthalene Substitution Pattern on Interstrand Cross-Linking Efficiency (2004)

[reaction: see text] Using a series of synthetic azinomycin analogues, it is shown that the efficiency of in vitro DNA interstrand cross-linking is markedly reduced when either the C-5' methyl group or both the C-5' methyl and C-3' methoxy groups are deleted from the naphthalene ring.
7-Hydroxy-8-acetylcoumarin N-1-(Carboxymethyl)pyridinium Chloride Hydrazone (2008)

n/a
Short‐length rate‐compatible code design for noncoherent detection (2019)

Summary In this paper, we propose a simple method for generating short‐length rate‐compatible codes that are robust to noncoherent detection for M ‐PSK constellations. For any given constellation set, first we use a greedy algorithm to construct a family of rotationally invariant codes. Then, by properly modifying such codes, we obtain a new family of codes that are robust to noncoherent detection. We briefly discuss the optimality of the constructed codes for special cases of BPSK and QPSK constellations. Our method provides an upper bound for the length of optimal codes with a given desired noncoherent distance. We also derive a simple asymptotic upper bound on the frame error rate (FER) of such codes and provide some simulations. Finally, the problem of designing binary codes that are robust to noncoherent detection for QPSK constellation is briefly discussed.
How relevant are growth and maturation factors to the B lymphocyte response induced by LPS? (1985)

For the purpose of arriving at a unifying concept concerning the mechanisms in control of B lymphocyte responses, LPS or anti-lg receptor antibodies have conveniently served as substitutes for antigen. We report that the proliferative B cell responses in serum protein free medium to each of these polyclonal activators differ in the requirement for B cell growth factors (BCGF). Murine B lymphocytes which were prestimulated with anti-lg (Fab')2 antibody could readily be induced by semipurified BCGF (containing some IL2 activity) to incorporate thymidine. In contrast, B lymphocytes which were prestimulated with LPS failed to respond to BCGF, but could be restimulated by LPS. We have also shown that the dependence on B cell maturation factors of antigen affinity enriched B lymphocytes to develop into antibody forming cells (AFC) in response to LPS, depends on the antigen for which they were selected. B cells that have been affinity enriched with chicken red blood cells (CRBC) and stimulated by LPS to proliferate require maturation factors in order to generate a CRBC specific IgM response. In contrast, B cells that have been affinity enriched for TNP may be induced by LPS alone to generate TNP specific AFC independent of maturation factors. The results question the general validity of theoretical concepts concerning the role of lymphokines in B cell triggering, where such concepts are derived from experiments with LPS-activated B cells.
Effects of a medical emergency team on reduction of incidence of and mortality from unexpected cardiac arrests in hospital: preliminary study (2002)

In clinically unstable inpatients early intervention by a medical emergency team significantly reduces the incidence of and mortality from unexpected cardiac arrest in hospital.
Determination of the populations of metastable levels in Gd vapor by a laser spectroscopy method during electron-beam evaporation of the metal (1976)

The relative populations of the levels of the a/sup 9/D/sup 0/ term in the electron configuration 4f/sup 7/5d6s/sup 2/ of atomic gadolinium were determined. Atomic vapor was obtained by evaporation of Gd with an electron beam. The distribution of the populations of all five levels of the a/sup 9/D/sup 0/ term differed considerably from the Boltzmann form.
The New Custodians of the State: Programmatic Elites in French Society (2011)

International audience
Morphological and immunocytochemical characteristics of human tumor cell lines for use in a disease-oriented anticancer drug screen. (1992)

A panel of 60 human tumor cell lines is currently being used in the U.S. National Cancer Institute's in vitro anticancer drug screen. The panel is organized into 7 subpanels; 6 leukemia/lymphoma lines comprise one subpanel, and 54 other lines are organized into subpanels representing solid tumors of the central nervous system (CNS), colon, lung, ovaries, kidneys and melanomas. In the present study, the leukemia and lymphoma cell lines were analyzed by flow cytometry for appropriate CD antigens; all but 1 line showed patterns of expression consistent with their reported derivations. The solid tumor lines were characterized individually using morphological and immunocytochemical techniques to determine their relative degrees of representativity for the subpanels within which they are currently grouped. Histological, histochemical and ultrastructural examinations were performed on cell lines grown under identical conventional culture conditions and as xenografts in nude mice. Immunocytochemistry using panels of antibodies raised against 6 types of intermediate filaments, 7 adenocarcinoma-associated antigens, 7 melanoma/neuro-ectodermal-associated antigens, 3 neuroendocrine-associated antigens, 9 urinary tract associated antigens, and 4 markers of muscle differentiation was done on cells grown in monolayer culture. Central nervous system (CNS) cell lines lacked expression of glial fibrillary acidic protein, but all had other features consistent with derivation from glioblastoma. Lines derived from adenocarcinomas of the colon, lung and ovary, for the most part, expressed adenocarcinoma-associated antigens and showed histological and/or ultrastructural evidence of gland formation and other adenomatous features. Most of these lines were poorly differentiated. Lines derived from large-cell and squamous-cell cancers also showed some characteristics consistent with their reported origins, except for one line which showed immunocytochemical and morphologic characteristics consistent with rhabdomyosarcoma. The 2 lines derived from small cell lung cancer (SCLC) lacked neurosecretory granules and 3 other SCLC markers but showed morphologic features consistent with SCLC. Most melanoma cell lines strongly expressed melanoma-associated antigens and were morphologically similar to human melanoma. Five lines produced premelanosomes, melanosomes or melanin. Most of the renal cancer cell lines showed morphologic or immunocytochemical features consistent with renal clear cell carcinoma. Collectively, these morphological and immunocytochemical analyses provide information concerning tissue of origin, tumor type, degree of differentiation and other biologic features essential to the use of these lines in a disease-oriented in vitro antitumor drug screen and to the interpretation of data derived therefrom.
Special Issue “Feature Papers in Biosensors Section 2022” (2023)

Biosensors are devices composed of a biorecognition part and of a transduction part [...].
160 THE EFFECTS OF ZINC DEFICIENCY ON GLUCOSE TOLERANCE AND GLUCAGON STIMULATED INSULIN SECRETION: (2005)

<h3>Purpose</h3> Severe zinc (Zn) deficiency has been shown to inhibit INS storage and release. We tested the hypothesis that mild and moderate, as well as severe, Zn deficiency alters glucose (GLC) homeostasis by affecting INS release, using GLC and glucagon as physiologically different INS secretogogues. <h3>Methods</h3> Weanling rats were fed diets containing different levels of Zn: very low Zn (VLZ, ≤1 mg Zn/kg diet), low Zn (LZ, 7 mg Zn/kg diet), mildly low Zn (MLZ, 15 mg Zn/kg diet), and control (25 mg Zn/kg diet), ad libitum for 3 weeks. In anticipation of reduced food intake, an additional group was pair-fed (PF) to VLZ rats. After 3 weeks on respective diets, rats were fasted overnight (12h), then given an intraperitoneal (ip) GLC injection (2 g/kg body weight) or ip glucagon injection (200 μg/kg body weight). Plasma samples for INS and GLC were collected at baseline and at periodic time intervals after injection. <h3>Results</h3> In the basal state, no differences in resting plasma GLC between groups were noted. INS values were significantly decreased in VLZ and PF relative to controls with MLZ and LZ having intermediate levels. Basal (Table) INS/GLC ratios were significantly lower in all treatment groups compared to controls and were lowest in VLZ and PF. In response to ip GLC, plasma GLC levels rose similarly in all groups. INS levels remained low in VLZ and PF compared to controls (p ≤ 0.01) and the area beneath the INS curve (AUCi) was lowest in VLZ and PF rats compared to other groups. In response to ip glucagon, plasma GLC levels rose similarly in all groups while INS levels were lower in VLZ and PF rats compared to controls after 60 min (p ≤ 0.01). AUCi after glucagon was significantly lower in VLZ rats compared to LZ, MLZ and controls (p≤0.05) and lower (p=0.07) than PF. INS levels increased less in all Zn deficient groups relative to controls after glucagon as opposed to ip GLC. <h3>Conclusion</h3> These results confirm that INS secretion is depressed by degrees of Zn deficiency that may be observed in humans. Whether the abnormality is due to Zn-induced inability to store or release INS is not known, but both mechanisms are likely to be affected.
Visual tracking for human-computer interaction (2003)

The purpose of this master's thesis project is to design, implement and evaluate vision-based user interfaces for use in the context of virtual environments. Three interfaces are treated. The first one is a 4 degrees of freedom (DOF) mouse that can track the position and 1 DOF or rotation (roll) of a user's hand. The second one is a 6 DOF mouse that can track both the position and the orientation of a user's hand in 3D space. Finally the third one is a laser pointing interface used to track the laser spot of a standard laser pointer, in order to interact with a large screen display. The two latter interfaces use an auto-calibrated approach based on planar homography, that distinguish them from the standard computer-vision based approach which requires a previous step of calibration.
Ultrastructural Studies in the Lytic Phase of Progressive Multifocal Leukoencephalopathy in AIDS Patients (1993)

Brain fragments from eight cases (four autopsies and four biopsies) of patients with acquired immune deficiency syndrome (AIDS) with JC virus (JCV) lytic infections were examined ultrastructurally. Particular efforts were made to look for virions and their subcellular distribution in cells not usually involved by papovavirus infection. The cellular and subcellular distribution of virions was investigated with emphasis on cell types not normally associated with papovavirus infection. The pattern of JCV infection was as follows: 1) oligodendrocytes; nucleus only, 7 cases; cytoplasm only, no cases; 2) astrocytes (normal and "bizarre"); nucleus and cytoplasm, two cases; cytoplasm only, four cases; 3) macrophages; nucleus and cytoplasm, one case; cytoplasm only, four cases; and 4) neurons; nucleus and cytoplasm, two cases; cytoplasm only, three cases. Perivascular, endothelial, ependymal, and microglial cells were never infected. Our ultrastructural data indicate that cell types other than oligodendrocytes can be involved productively by JCV in the lytic phase of progressive multifocal leukoencephalopathy (PML) in AIDS patients. Neuronal cells, especially, can be infected productively by the JCV, and this should be considered in clinical interpretation of cortical symptoms and signs in suspected or proven cases of PML.
ChemInform Abstract: Photochemical Series. Part 150. General Series. Part 208. A Photochemical Long‐Range Pinacol Rearrangement. Mechanistic and Exploratory Organic Photochemistry. (1987)

Abstract The pentenol (Ia) and the methyl ethers (Ib), (Va), and (Vb) are prepared from the ester (II) as shown in the reaction scheme.
Performance Improvement of Channel Equalizer for Multipath Outside the Guard Interval of ISDB-T Signals (2012)

Most digital terrestrial television broadcasting systems including Integrated Services Digital Broadcasting-Terrestrial (ISDB-T) system use the orthogonal frequency division multiplexing (OFDM) scheme, which is robust against echoes (multipath interference) due to the insertion of a guard interval. However, echoes can occur outside the guard interval and degrade the quality of the received signal, especially in single frequency network (SFN). To overcome this problem, a channel equalizer that performs a Fast Fourier transform (FFT) on several OFDM symbols in combination and then equalizes the frequency characteristics in the frequency domain has been shown to be effective. In this paper, we extend this scheme and propose an equalization algorithm using serially concatenated two-frequency domain equalizers. Simulation results showed that the performance was improved, especially when the delay spread was within the guard interval length. We also added an adaptive control method to the leak process part of the channel estimation. Results of a field experiment in a receiving environment with reflection waves from the mountains further demonstrated the effectiveness of the proposed method.