gebhart/patrepeval huggingface dataset:
Foreground contextual fear memory consolidation requires two independent phases of hippocampal ERK/CREB activation (2006)

Fear conditioning is a popular model for investigating physiological and cellular mechanisms of memory formation. In this paradigm, a footshock is either systematically associated to a tone (paired conditioning) or is pseudorandomly distributed (unpaired conditioning). In the former procedure, the tone/shock association is acquired, whereas in the latter procedure, the context/shock association will prevail. Animals with chronically implanted recording electrodes show enhanced amplitude of the extracellularly recorded field EPSP in CA1 pyramidal cells for up to 24 h after unpaired, but not paired, fear conditioning. This is paralleled by a differential activation of the ERK/CREB pathway in CA1, which is monophasic in paired conditioning (0-15 min post-conditioning), but biphasic (0-1 h and 9-12 h post-conditioning) in unpaired conditioning as revealed by immunocytochemistry and Western blotting. Intrahippocampal injection of the MEK inhibitor U0126 prior to each phase prevents the activation of both ERK1/2 and CREB after unpaired conditioning. Block of any activation phase leads to memory impairment. We finally reveal that the biphasic activation of ERK/CREB activity is independently regulated, yet both phases are critically required for the consolidation of long-term memories following unpaired fear conditioning. These data provide compelling evidence that CA1 serves different forms of memory by expressing differential cellular mechanisms that are dependent on the training regime.
Exploration d'architectures basée sur la génération automatique de plates-formes matérielles et le portage rapide du logiciel (2007)

: The proposed approach is an iterative flow in three steps. The first one is the fast development and modification of the architecture executable model. The second one is the adaptation of the embedded software. The third one is the hardware and software architecture exploration. A tool has been developed in order to create and modify quickly a hardware architecture model. It uses flexible sub-systems. One method in order to adapt the embedded software is exposed, it includes: to manually add some parameterization in the software, an automatic extraction of the architecture characteristics, the generation of the low level code sources. To finish a method allow to simulate processors at different level of simulation with their embedded software, high level for fast simulation, low level for performance measurements. Following results, hardware and software are modified and the flow can restart. This flow was tested on a real application, a parallelized H264 encoder.
Sports Activity and Arrhythmic Risk in Cardiomyopathies and Channelopathies: A Critical Review of European Guidelines on Sports Cardiology in Patients with Cardiovascular Diseases (2021)

The prediction and prevention of sudden cardiac death is the philosopher's stone of clinical cardiac electrophysiology. Sports can act as triggers of fatal arrhythmias and therefore it is essential to promptly frame the athlete at risk and to carefully evaluate the suitability for both competitive and recreational sports activity. A history of syncope or palpitations, the presence of premature ventricular complexes or more complex arrhythmias, a reduced left ventricular systolic function, or the presence of known or familiar heart disease should prompt a thorough evaluation with second level examinations. In this regard, cardiac magnetic resonance and electrophysiological study play important roles in the diagnostic work-up. The role of genetics is increasing both in cardiomyopathies and in channelopathies, and a careful evaluation must be focused on genotype positive/phenotype negative subjects. In addition to being a trigger for fatal arrhythmias in certain cardiomyopathies, sports also play a role in the progression of the disease itself, especially in the case arrhythmogenic right ventricular cardiomyopathy. In this paper, we review the latest European guidelines on sport cardiology in patients with cardiovascular diseases, focusing on arrhythmic risk stratification and the management of cardiomyopathies and channelopathies.
Zoster-Associated Prothrombotic Plasma Exosomes and Increased Stroke Risk (2022)

Herpes zoster (HZ; shingles) caused by varicella zoster virus reactivation increases stroke risk for up to 1 year after HZ. The underlying mechanisms are unclear, however, the development of stroke distant from the site of zoster (eg, thoracic, lumbar, sacral) that can occur months after resolution of rash points to a long-lasting, virus-induced soluble factor (or factors) that can trigger thrombosis and/or vasculitis. Herein, we investigated the content and contributions of circulating plasma exosomes from HZ and non-HZ patient samples. Compared with non-HZ exosomes, HZ exosomes (1) contained proteins conferring a prothrombotic state to recipient cells and (2) activated platelets leading to the formation of platelet-leukocyte aggregates. Exosomes 3 months after HZ yielded similar results and also triggered cerebrovascular cells to secrete the proinflammatory cytokines, interleukin 6 and 8. These results can potentially change clinical practice through addition of antiplatelet agents for HZ and initiatives to increase HZ vaccine uptake to decrease stroke risk.
Detrecting and Locating Partial Discharges in Transformers (2005)

A collaborative research between the Oak Ridge National Laboratory (ORNL), the American Electric Power (AEP), the Tennessee Valley Authority (TVA), and the State of Ohio Energy Office (OEO) has been formed to conduct a feasibility study to detect and locate partial discharges (PDs) inside large transformers. The success of early detection of the PDs is necessary to avoid costly catastrophic failures that can occur if the process of PD is ignored. The detection method under this research is based on an innovative technology developed by ORNL researchers using optical methods to sense the acoustical energy produced by the PDs. ORNL researchers conducted experimental studies to detect PD using an optical fiber as an acoustic sensor capable of detecting acoustical disturbances at any point along its length. This technical approach also has the potential to locate the point at which the PD was sensed within the transformer. Several optical approaches were experimentally investigated, including interferometric detection of acoustical disturbances along the sensing fiber, light detection and ranging (LIDAR) techniques using frequency modulation continuous wave (FMCW), frequency modulated (FM) laser with a multimode fiber, FM laser with a single mode fiber, and amplitude modulated (AM) laser with a multimode fiber. The implementation of the optical fiber-based acoustic measurement technique would include installing a fiber inside a transformer allowing real-time detection of PDs and determining their locations. The fibers are nonconductive and very small (core plus cladding are diameters of 125 μm for single-mode fibers and 230 μm for multimode fibers). The research identified the capabilities and limitations of using optical technology to detect and locate sources of acoustical disturbances such as in PDs in large transformers. Amplitude modulation techniques showed the most promising results and deserve further research to better quantify the technique’s sensitivity and its ability to characterize a PD event. Other sensing techniques have been also identified, such as the wavelength shifting fiber optics and custom fabricated fibers with special coatings.
Lightning: A Hard Real-Time, Fast, and Lightweight Low-End Wireless Sensor Election Protocol for Acoustic Event Localization (2008)

We present the Lightning Protocol, a hard real-time, fast, and lightweight protocol to elect the sensor closest to an impulsive sound source. This protocol can serve proximity-based localization or leader election for sensor collaboration. It utilizes the fact that electromagnetic waves propagate much faster than acoustic waves to efficiently reduce the number of contending sensors in the election. With simple RF bursts, most basic comparison operations, no need of clock synchronization, and a memory footprint as small as 5,330 bytes of ROM and 187 bytes of RAM, the protocol incurs O(1) transmissions, irrespective of the sensor density, and guarantees hard real-time (O(1)) localization time cost. Experiment results using UC Berkeley Motes in a common office environment demonstrate that the time delay for the Lightning Protocol is on the order of milliseconds. The simplicity of the protocol reduces memory cost, computation complexity, and programming difficulty, making it desirable for low-end wireless sensors.
Enhancement of Tumor Blood Flow and Tumoricidal Effect of Doxorubicin by Intraportal Epinephrine in Experimental Liver Metastasis (1987)

Laser Doppler capillary perfusion monitoring was performed in 25 Sprague-Dawley rats with solitary intrahepatic implants of Walker carcinosarcomas. Doses of intraportal epinephrine from 1 to 10 micrograms produced an immediate rise in capillary blood flow, reaching peak levels by 16 s. The increased flow lasted an average of 57 s. Because epinephrine selectively increased tumor blood flow, studies were performed to determine if enhancement of the chemotherapeutic effect of doxorubicin could be achieved. Forty-two rats with seven-day hepatic implants were treated sequentially with intraportal epinephrine (10 micrograms) and doxorubicin hydrochloride (10 mg/kg) or doxorubicin alone. After only two courses of chemotherapy, a significant difference in necrosis and cell viability was obtained in those animals treated with epinephrine intraportally prior to doxorubicin infusion. Enhancement of the tumoricidal effect of chemotherapy can be achieved by manipulating the blood flow to developing tumors pharmacologically.
A novel and practical approach for determination of the acoustic nonlinearity parameter using a pulse-echo method (2016)

Measurements of the acoustic nonlinearity parameter are frequently made for early detection of damage in various materials. The practical implementation of the measurement technique has been limited to the through-transmission setup for determining the nonlinearity parameter of the second harmonic wave. In this work, a feasibility study is performed to assess the possibility of using pulse-echo methods in determining the nonlinearity parameter of solids with a stress-free boundary. The multi-Gaussian beam model is developed based on the quasilinear theory of the KZK equation. Simulation results and discussion are presented for the reflected beam fields of the fundamental and second harmonic waves, the uncorrected behavior and the properties of total correction that incorporate reflection, attenuation and diffraction effects.
Angiogenin Enhances Cell Migration by Regulating Stress Fiber Assembly and Focal Adhesion Dynamics (2011)

Angiogenin (ANG) acts on both vascular endothelial cells and cancer cells, but the underlying mechanism remains elusive. In this study, we carried out a co-immunoprecipitation assay in HeLa cells and identified 14 potential ANG-interacting proteins. Among these proteins, β-actin, α-actinin 4, and non-muscle myosin heavy chain 9 are stress fiber components and involved in cytoskeleton organization and movement, which prompted us to investigate the mechanism of action of ANG in cell migration. Upon confirmation of the interactions between ANG and the three proteins, further studies revealed that ANG co-localized with β-actin and α-actinin 4 at the leading edge of migrating cells. Down-regulation of ANG resulted in fewer but thicker stress fibers with less dynamics, which was associated with the enlargements of focal adhesions. The focal adhesion kinase activity and cell migration capacity were significantly decreased in ANG-deficient cells. Taken together, our data demonstrated that the existence of ANG in the cytoplasm optimizes stress fiber assembly and focal adhesion formation to accommodate cell migration. The finding that ANG promoted cancer cell migration might provide new clues for tumor metastasis research.
ChemInform Abstract: ACENAPHTHENEDITHIONE (1985)

Abstract Das aus (Ia) dargestellte Xanthogenat (Ib) cyclisiert zum Dithiolan (II), das beim Bestrahlen Intermediär das im Titel genannte Dithion (III) liefert.
Biomolecule-functionalized polymer brushes (2013)

Functional polymer brushes have been utilized extensively for the immobilization of biomolecules, which is of crucial importance for the development of biosensors and biotechnology. Recent progress in polymerization methods, in particular surface-initiated atom transfer radical polymerization (ATRP), has provided a unique means for the design and synthesis of new biomolecule-functionalized polymer brushes. This current review summarizes such recent research activities. The different preparation strategies for biomolecule immobilization through polymer brush spacers are described in detail. The functional groups of the polymer brushes used for biomolecule immobilization include epoxide, carboxylic acid, hydroxyl, aldehyde, and amine groups. The recent research activities indicate that functional polymer brushes become versatile and powerful spacers for immobilization of various biomolecules to maximize their functionalities. This review also demonstrates that surface-initiated ATRP is used more frequently than other polymerization methods in the designs of new biomolecule-functionalized polymer brushes.
Surface Plasmon Resonance sensor showing enhanced sensitivity for CO_2 detection in the mid-infrared range (2009)

We present the first optical sensor based on Surface Plasmon Resonance (SPR) operating in the mid-infrared range. The experimental setup is based on a Kretschmann geometry with Ti/Au layers deposited on a CaF(2) prism where light excitation is provided by a Quantum Cascade Laser (QCL) source. Evidence of SPR is presented and the sensing capability of the system is demonstrated by using CO(2) and N(2) mixtures as test samples. Due to the absorption of CO(2) at this wavelength, it is shown that the sensitivity of this configuration is five times higher than a similar SPR sensor operating in the visible range of the spectrum.
The structural basis for high affinity binding of α1-acid glycoprotein to the potent antitumor compound UCN-01 (2021)

The α1-acid glycoprotein (AGP) is an abundant blood plasma protein with important immunomodulatory functions coupled to endogenous and exogenous ligand-binding properties. Its affinity for many drug-like structures, however, means AGP can have a significant effect on the pharmokinetics and pharmacodynamics of numerous small molecule therapeutics. Staurosporine, and its hydroxylated forms UCN-01 and UCN-02, are kinase inhibitors that have been investigated at length as antitumour compounds. Despite their potency, these compounds display poor pharmokinetics due to binding to both AGP variants, AGP1 and AGP2. The recent renewed interest in UCN-01 as a cytostatic protective agent prompted us to solve the structure of the AGP2-UCN-01 complex by X-ray crystallography, revealing for the first time the precise binding mode of UCN-01. The solution NMR suggests AGP2 undergoes a significant conformational change upon ligand binding, but also that it uses a common set of sidechains with which it captures key groups of UCN-01 and other small molecule ligands. We anticipate that this structure and the supporting NMR data will facilitate rational redesign of small molecules that could evade AGP and therefore improve tissue distribution.
Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration (1995)

Miller-Dieker lissencephaly syndrome (MDS) is a human developmental brain malformation caused by neuronal migration defects resulting in abnormal layering of the cerebral cortex. LIS1, the gene defective in MDS, encodes a subunit of brain platelet-activating factor (PAF) acetylhydrolase which inactivates PAF, a neuroregulatory molecule. We have isolated murine cDNAs homologous to human LIS1 and mapped these to three different chromosomal loci (Lis1, Lis3, Lis4). The predicted sequences of murine Lis1 protein and its human homolog LIS1 are virtually identical. In the developing mouse and human, Lis1 and LIS1 genes were strongly expressed in the cortical plate. In the adult mouse Lis1 transcripts were abundant in cortex and hippocampus. The direct correlation between cortical defects in MDS patients and Lis1 expression in the murine cortex suggest that the mouse is a model system suitable to study the mechanistic basis of this intriguing genetic disease.
A secure routing protocol for ad hoc networks (2003)

Most recent ad hoc network research has focused on providing routing services without considering security. We detail security threats against ad hoc routing protocols, specifically examining AODV and DSR. In light of these threats, we identify three different environments with distinct security requirements. We propose a solution to one, the managed-open scenario where no network infrastructure is pre-deployed, but a small amount of prior security coordination is expected. Our protocol, authenticated routing for ad hoc networks (ARAN), is based on certificates and successfully defeats all identified attacks.
On the low-power design, stability improvement and frequency estimation of the CMOS ring oscillator (2012)

In this paper, a simple method allowing optimization of the CMOS ring oscillator frequency dispersion and power consumption is discussed. It is shown, that for range of tens of MHz and less, the power consumption and variation of the frequency can be considerably reduced by using 3-stage, resistively coupled ring oscillator, with minimum channel width W and large channel length L MOS transistors. In addition, a simple analysis allowing to estimate the oscillator frequency from the process and transistor parameter values is provided.
Definition of Smad3 Phosphorylation Events That Affect Malignant and Metastatic Behaviors in Breast Cancer Cells (2014)

Smad3, a major intracellular mediator of TGFβ signaling, functions as both a positive and negative regulator in carcinogenesis. In response to TGFβ, the TGFβ receptor phosphorylates serine residues at the Smad3 C-tail. Cancer cells often contain high levels of the MAPK and CDK activities, which can lead to the Smad3 linker region becoming highly phosphorylated. Here, we report, for the first time, that mutation of the Smad3 linker phosphorylation sites markedly inhibited primary tumor growth, but significantly increased lung metastasis of breast cancer cell lines. In contrast, mutation of the Smad3 C-tail phosphorylation sites had the opposite effect. We show that mutation of the Smad3 linker phosphorylation sites greatly intensifies all TGFβ-induced responses, including growth arrest, apoptosis, reduction in the size of putative cancer stem cell population, epithelial-mesenchymal transition, and invasive activity. Moreover, all TGFβ responses were completely lost on mutation of the Smad3 C-tail phosphorylation sites. Our results demonstrate a critical role of the counterbalance between the Smad3 C-tail and linker phosphorylation in tumorigenesis and metastasis. Our findings have important implications for therapeutic intervention of breast cancer.
Transonic Free-To-Roll Analysis of the F-35 (Joint Strike Fighter) Aircraft (2006)

The free-to-roll technique is used as a tool for predicting areas of uncommanded lateral motions. Recently, the NASA/Navy/Air Force Abrupt Wing Stall Program extended the use of this technique to the transonic speed regime. Using this technique, this paper evaluates various wing configurations on the Joint Strike Fighter (F-35) aircraft. The configurations investigated include leading- and trailing-edge flap deflections, leading-edge flap gap seals, and vortex generators. These tests were conducted in the NASA Langley 16-Foot Transonic Tunnel. The analysis used a modification of a figure of merit developed during the Abrupt Wing Stall Program to discern configuration effects. The results showed how the figure of merit can be used to schedule wing flap deflections to avoid areas of uncommanded lateral motion. The analysis also used both static and dynamic wind-tunnel data to provide insight into the uncommanded lateral behavior. The dynamic data were extracted from the time history data using parameter identification techniques. In general, sealing the gap between the inboard and outboard leading-edge flaps on the Navy version of the F-35 eliminated uncommanded lateral activity or delayed the activity to a higher angle of attack.
Population dose‐response analysis of daily seizure count following vigabatrin therapy in adult and pediatric patients with refractory complex partial seizures (2014)

Vigabatrin is an irreversible inhibitor of γ-aminobutyric acid transaminase (GABA-T) and is used as an adjunctive therapy for adult patients with refractory complex partial seizures (rCPS). The purpose of this investigation was to describe the relationship between vigabatrin dosage and daily seizure rate for adults and children with rCPS and identify relevant covariates that might impact seizure frequency. This population dose-response analysis used seizure-count data from three pediatric and two adult randomized controlled studies of rCPS patients. A negative binomial distribution model adequately described daily seizure data. Mean seizure rate decreased with time after first dose and was described using an asymptotic model. Vigabatrin drug effects were best characterized by a quadratic model using normalized dosage as the exposure metric. Normalized dosage was an estimated parameter that allowed for individualized changes in vigabatrin exposure based on body weight. Baseline seizure rate increased with decreasing age, but age had no impact on vigabatrin drug effects after dosage was normalized for body weight differences. Posterior predictive checks indicated the final model was capable of simulating data consistent with observed daily seizure counts. Total normalized vigabatrin dosages of 1, 3, and 6 g/day were predicted to reduce seizure rates 23.2%, 45.6%, and 48.5%, respectively.
Collateral Ventilation (1978)

The photoinitiated bulk polymn. of liq. cryst. thiolene monomers (having a mercapto group at one end and an olefinic bond at the other) based on a Ph benzoate core was investigated and the structure of the corresponding polymers analyzed. We show that polymn. occurs substantially in bulk, and can be initiated on demand by UV irradn. The liq. cryst. thiolene polymers exhibit a nematic mesophase, and the mol. wt., mol. wt. distribution and overall conversion are characteristic for polymers obtained by a step-growth polymn. Using NMR spectroscopy, we show that anti-Markovnikov structures are predominantly formed, with a small fraction of the structures displaying different configurations that can be attributed to thiol olefin addn.-cooxidn. processes or to homopolymn. of the olefinic moiety. The conversions of the thiol and vinyl groups were monitored using time-resolved Raman spectroscopy and dissimilar partial reaction rates were obsd. [on SciFinder (R)]
Computation of the position and the width of theB−1s22s22p21Dshape resonance (1998)

State-specific configuration interaction in the continuum calculations, with electron correlation included, shows that shape resonances in polyelectronic atoms can be computed systematically to a high degree of accuracy. Specifically, the ${\mathrm{B}}^{\mathrm{\ensuremath{-}}}{1s}^{2}{2s}^{2}{2p}^{2}{}^{1}D$ state is computed to be a shape resonance with $Ε=95\mathrm{meV}$ and $\ensuremath{\Gamma}=54\mathrm{meV},$ confirming the tentative identification given recently by Lee et al. [Phys Rev. A 53, R633 (1996)] for the lowest resonance structure observed in scattering experiments.
Noise Modeling For Smoothing The Colour Histogram (1996)

Publication in the conference proceedings of EUSIPCO, Trieste, Italy, 1996