gebhart/patrepeval huggingface dataset:
Prior endurance exercise prevents postprandial lipaemia‐induced increases in reactive oxygen species in circulating CD31+ cells (2011)

We hypothesized that prior exercise would prevent postprandial lipaemia (PPL)-induced increases in intracellular reactive oxygen species (ROS) in three distinct circulating angiogenic cell (CAC) subpopulations. CD34(+), CD31(+)/CD14(-)/CD34(-), and CD31(+)/CD14(+)/CD34(-) CACs were isolated from blood samples obtained from 10 healthy men before and 4 h after ingesting a high fat meal with or without ∼50 min of prior endurance exercise. Significant PPL-induced increases in ROS production in both sets of CD31(+) cells were abolished by prior exercise. Experimental ex vivo inhibition of NADPH oxidase activity and mitochondrial ROS production indicated that mitochondria were the primary source of PPL-induced oxidative stress. The attenuated increases in ROS with prior exercise were associated with increased antioxidant gene expression in CD31(+)/CD14(-)/CD34(-) cells and reduced intracellular lipid uptake in CD31(+)/CD14(+)/CD34(-) cells. These findings were associated with systemic cardiovascular benefits of exercise, as serum triglyceride, oxidized low density lipoprotein-cholesterol, and plasma endothelial microparticle concentrations were lower in the prior exercise trial than the control trial. In conclusion, prior exercise completely prevents PPL-induced increases in ROS in CD31(+)/CD14(-)/CD34(-) and CD31(+)/CD14(+)/CD34(-) cells. The mechanisms underlying the effects of exercise on CAC function appear to vary among specific CAC types.
A new synthesis of 6‐(alkyl)amino‐3‐aryl(alkyl)‐1,2,4,5‐tetrazines (1981)

Abstract A new method for the preparation of 6‐(alkyl)amino‐3‐aryl(alkyl)‐1,2,4,5‐tetrazines is described. Dissolving 3‐aryl(alkyl)‐1,2,4,5‐tetrazines in liquid ammonia or a primary aliphatic amine at −35° to −40°, followed by addition of potassium permanganate gives the title compounds in reasonable to excellent yields.
Thermal-Fluid Sciences Laboratory Course (2003)

At the Department of Engineering Technology at the University of Toledo we are working on introducing laboratory course in thermal-fluid sciences with the elements of controls. The objective is to create a course where the students will learn to see connections between the three branches of the thermal-fluid sciences and will learn to appreciate the integrated nature of modern systems. The proposed laboratory course will be structured around four “equipment centers” represented important areas of applications in the thermal-fluid sciences: 1) Armfield Modules (turbomachinery), 2) Steam Motor and Energy Conversion Set, 3) Modular Air Flow Laboratory, and 4) Experimental Heat Pump and Air Cooler. The students will take the course after they finish courses in Thermodynamics and Fluid Mechanics. The course will give our students an opportunity to observe how the concepts and principles learned in the classroom can be applied in a practical situation. To extend the instructional capability of the equipment and to give the students knowledge of modern instrumentation and control systems we use LabVIEW for computerization and automation of this laboratory. The experiments that have already been developed for the course as well as experiments that have been planned for the future are presented in the paper.
Stability of AlGaN/GaN high-power HEMTs under DC and RF stresses (2004)

The stability of high-power AlGaN/GaN HEMTs under DC and RF stresses was evaluated. For 50 hours of DC stresses, 100 µm devices exhibited ∼3% full-channel drain current degradation within the first few minutes and another ∼1% current loss during the rest of the stress period. In response to the RF stresses under pulsed conditions at 2.8 GHz, the output power of 1.5 mm devices degraded by ∼13% after 108 hours of stress. Current DLTS measurements revealed the creation of a 0.4 eV trap from the stressed and aged devices.
Daily phosphodiesterase type 5 inhibitor therapy: a new treatment option for prostatitis/prostatodynia? (2015)

The management of patients with chronic pelvic pain attributed to chronic prostatitis has always been rather unsatisfactory. Even prolonged treatment with an aminoquinolone, such as ciprofloxacin, and an anti‐inflammatory agent, or, alternatively an alpha‐blocker, seldom results in rapid resolution of the symptoms, and is commonly completely ineffective.
Structures of two head-to-head allene dimers (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructures of two head-to-head allene dimersS. R. Byrn, E. Maverick, Oliver J. Muscio Jr., K. N. Trueblood, and Thomas L. JacobsCite this: J. Am. Chem. Soc. 1971, 93, 24, 6680–6682Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December 1971https://pubs.acs.org/doi/10.1021/ja00753a062https://doi.org/10.1021/ja00753a062research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The parameters characterising each statistical distribution used in this manuscript. (2016)

&lt;p&gt;The parameters characterising each statistical distribution used in this manuscript.&lt;/p&gt;
Trace Analyses of Hydrocarbons to Understand the Fate of These Contaminants in Aquifers (2005)

In recent years, it has become increasingly evident that the problems related to soil and groundwater pollution are of major concern in industrial countries. The persistence of contamination in the environment and the toxicity of pollutants have led to important investigations and researches in this field. The competent authorities have set up regulations and methodologies to face the problems of contaminated sites in order to repair the errors of the past in a pragmatic way. These are risk based tools and take into account both water resources and health. They allow the treatment to be adjusted to the future use of the site. In this context, understanding the mechanisms of pollution transfer from the soil to the water phase becomes crucial to evaluate the quantitative and qualitative impact on the water resources. As a matter of fact, numerous processes-physical, chemical and in particular biological-are susceptible to affect the quantity and particularly the composition of the contaminant. This paper will present methodologies allowing the biological fate and the physical state of hydrocarbons in water to be perceived. Results from two real cases will be presented: the first one contaminated with gasoline and generating an important plume of dissolved monoaromatic compounds and the other one contaminated with coal tars inducing a pollution with polyaromatic hydrocarbons.
Mode of Action of Glycogen Branching Enzyme from Neurospora crassa (1990)

Neurospora crassa branching enzyme [EC 2.4.1.18] acted on potato amylopectin or amylose to convert them to highly branched glycogen-type molecules which consisted of unit chains of six glucose units. The enzyme also acted on the amylopectin beta-limit dextrin, indicating that the enzyme acted on internal glucose chains as well as outer chains. By the combined action of N. crassa glycogen synthase [EC 2.4.1.11] and the branching enzyme, a glycogen-type molecule was formed from UDP-glucose. In the presence of primer glycogen, the glucose transfer reaction was accelerated by the addition of branching enzyme. On the other hand, the glucose transfer reaction by glycogen synthase did not occur without primers. When the branching enzyme was added, the glucose transfer occurred after a short time lag. This recovery of the glucose transfer reaction did not occur upon addition of the inactivated branching enzyme. The structure of the product formed by the combined action of the two enzymes was different from that of the intact N. crassa glycogen with respect to the distribution patterns of the unit chains.
Guidelines for Interpretation Required. (2018)

Conflict of interest statement

Professor Gatermann has received honoraria for preparing scientific conferences and physical resources for a research project of Beckman Coulter and bioMerioux that he initiated.

Professor Schaumburg and Professor Becker declare that no conflict of interest exists.
Issues related to testing of Space Station materials (1988)

Issues pertaining to the long life of Space Station materials and to the test methodology for the certification of these materials are presented. Consideration is given to atomic oxygen degradation, debris and micrometeoroid damage, and thermal cycling. It is noted that the integration of the combined effects of all of these phenomena is highly important as they cannot be viewed as separate isues.
A lion lentivirus related to feline immunodeficiency virus: epidemiologic and phylogenetic aspects (1994)

Feline immunodeficiency virus (FIV) is a novel lentivirus that is genetically homologous and functionally analogous to the human AIDS viruses, human immunodeficiency virus types 1 and 2. FIV causes immunosuppression in domestic cats by destroying the CD4 T-lymphocyte subsets in infected hosts. A serological survey of over 400 free-ranging African and Asian lions (Panthera leo) for antibodies to FIV revealed endemic lentivirus prevalence with an incidence of seropositivity as high as 90%. A lion lentivirus (FIV-Ple) was isolated by infection of lion lymphocytes in vitro. Seroconversion was documented in two Serengeti lions, and discordance of mother-cub serological status argues against maternal transmission (in favor of horizontal spread) as a major route of infection among lions. A phylogenetic analysis of cloned FIV-Ple pol gene sequences from 27 lions from four African populations (from the Serengeti reserve, Ngorongoro Crater, Lake Manyara, and Kruger Park) revealed remarkably high intra- and interindividual genetic diversity at the sequence level. Three FIV-Ple phylogenetic clusters or clades were resolved with phenetic, parsimony, and likelihood analytical procedures. The three clades, which occurred not only together in the same population but throughout Africa, were as divergent from each other as were homologous pol sequences of lentivirus isolated from distinct feline species, i.e., puma and domestic cat. The FIV-Ple clades, however, were more closely related to each other than to other feline lentiviruses (monophyletic for lion species), suggesting that the ancestors of FIV-Ple evolved in allopatric (geographically isolated) lion populations that converged recently. To date, there is no clear evidence of FIV-Ple-associated pathology, raising the possibility of a historic genetic accommodation of the lion lentivirus and its host leading to a coevolved host-parasite symbiosis (or commensalism) in the population similar to that hypothesized for endemic simian immunodeficiency virus without pathology in free-ranging African monkey species.
Characterization of lactotransferrin receptor in epithelial cell lines from non-malignant human breast, benign mastopathies and breast carcinomas. (1993)

The aim of this study was to investigate the presence of lactotransferrin receptor on breast non-malignant SV-40 immortalized cells (HBL100 and NB54T), benign mastopathy immortalized cells (NPM14T and NPM21T1), hst oncogene transformed HBL100 cell line (tumorigenic HH9 cells) and breast carcinoma cells (T47D, MCF7, VHB1, BT20 and MDA-MB 231). Flow cytometry analyses of the reversible binding of lactotransferrin labeled on its glycan moiety with fluorescein indicate, for the first time, that all these epithelial breast cell lines, express a specific lactotransferrin receptor. The binding parameters of [125I]-lactotransferrin to non-malignant cells, hst oncogene transformed cells and benign mastopathy cells are of the same order of magnitude as those determined for activated lymphocytes and for cancerous breast cell lines, except for MDA-MB 231 cells. MDA-MB 231 cells bind lactotransferrin with the lowest affinity and, in contrast to other analyzed breast cells, are not recognized by antibodies directed against lymphocyte lactotransferrin receptor. These results suggest that MDA-MB 231 lactotransferrin receptor is different from that characterized at the cell surface of other breast cells. In conclusion, since the lactotransferrin receptor expression was not enhanced at the surface of cancerous cell lines and was not altered by the oncogene transformation of a normal cell (HBL100) to a tumorigenic cell (HH9), the lactotransferrin receptor cannot be considered as a marker of tumor progression.
T-Cell–Derived Interferon-γ Contributes to Arteriolar Dysfunction During Acute Hypercholesterolemia (2007)

These data reveal a novel role of T-lymphocyte-derived IFN-gamma in the development of endothelial dysfunction in arterioles during hypercholesterolemia and extend our previous observations that IFN-gamma mediates both inflammatory and thrombogenic responses to hypercholesterolemia in postcapillary venules.
Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signalling pathway (2022)

SUMMARY iRhoms are pseudoprotease members of the rhomboid-like superfamily and are cardinal regulators of inflammatory and growth factor signalling; they function primarily by recognising transmembrane domains of their clients. Here we report an unexpected, and mechanistically distinct, nuclear function of iRhoms. iRhom2 is a non-canonical substrate of the signal peptidase complex (SPC), the protease that removes signal peptides from secreted proteins. Cleavage of iRhom2 generates an N-terminal fragment that enters the nucleus and modifies the cellular transcriptome. We observed elevated nuclear iRhom2 in skin biopsies of patients with psoriasis and tylosis with oesophageal cancer (TOC); increased SPC-mediated iRhom2 cleavage in a psoriasis model; and overlapping transcriptional signatures between psoriasis and expression of the iRhom2 N-terminus. This work highlights the pathophysiological significance of this SPC-dependent ER-to-nucleus signalling pathway, and is the first example of a rhomboid-like protein that mediates protease-regulated nuclear signalling.
Efficacy of single-agent decitabine in relapsed and refractory acute myeloid leukemia (2017)

Improving therapy for relapsed/refractory AML remains a challenge. We performed a retrospective analysis of outcomes following decitabine treatment in 34 patients with relapsed/refractory AML (median age, 62; median Charlson comorbidity score, 6). Decitabine, 20 mg/m<sup>2</sup> daily, was given in 5- (25%) or 10-day (75%) cycles. Overall response rate (OR) was 30% with 21% complete remission and 9% partial remission rate. Patients with therapy-related myeloid neoplasm (t-MN) and secondary AML had a significantly higher OR compared to those with de novo AML (70 vs. 30%; p = .02). Median overall survival of all patients was 8.5 months. Median survival in patients with t-MN or secondary AML was 12.4 months compared to 8 months in those with de novo AML (p = .20). Fifteen (44%) patients proceeded to hematopoietic stem cell transplant. These data support using 10-day treatment cycles of decitabine in patients with relapsed/refractory AML, particularly for those with secondary or therapy-related AML.
SuperMix: A Flexible Software Library for High-Frequency Circuit Simulation, Including SIS Mixers and Superconducting Elements (1999)

SuperMix&amp;quot; is a software library written to aid in the calculation and optimization of the signal and noise performance of high-frequency circuits, especially those including superconductors and superconducting tunnel junctions. Using this library, C++ programs can be written to simulate circuits of arbitrary size, complexity, and topology. The library includes an optimizer which can minimize an arbitrary error function by varying chosen circuit parameters. Using SuperMix, it is now possible to directly optimize an SIS receiver design to minimize the average noise temperature across the desired RF frequency band, including a full harmonic balance analysis at every frequency point together with a full analysis of the IF amplifier circuit and its noise contribution.
Editor’s Letter (2021)

1. Stanley J. Kon 1. Editor The performance of security selection within the Agency mortgage-backed securities market is primarily dependent on the quality of the trader’s prepayment model. Each prepayment wave has unique characteristics and an opportunity for dynamic adaptation. We begin
A Dynamic Packet Recovery Mechanism for Realtime Service in Mobile Computing Environments (2003)

This paper analyzes the characteristics of packet losses in mobile computing environments based on the Gilbert model and then describes a mechanism that can recover the lost audio packets using redundant data. Using information periodically reported by a receiver, the sender dynamically adjusts the amount and offset values of redundant data with the constraint of minimizing the bandwidth consumption of wireless links. Since mobile computing environments can be often characterized by frequent and consecutive packet losses, loss recovery mechanisms need to deal efficiently with both random and consecutive packet losses. To achieve this, the suggested mechanism uses relatively large, discontinuous exponential offset values. That gives the same effect as using both the sequential and interleaving redundant information. To verify the effectiveness of the mechanism, we extended and implemented RTP/RTCP and applications. The experimental results show that our mechanism, with an exponential offset, achieves a remarkably low complete packet loss rate and adapts dynamically to the fluctuation of the packet loss pattern in mobile computing environments.
In vivo expression of an overlapping gene encoded by the cucumoviruses. (1997)

We recently reported the molecular characterization and functional analysis of an overlapping gene 2b encoded by RNA 2 of the Q strain of cucumber mosaic cucumovirus (Q-CMV). We show here that the homologous gene encoded by the V strain of tomato aspermy cucumovirus (V-TAV) and the WAII strain of CMV (WAII-CMV), which is in a different subgroup to Q-CMV, is also expressed in vivo by demonstrating the accumulation of the mRNA (RNA 4A) and its protein in infected plants. Interestingly, RNA 4A of V-TAV is encapsidated in virions as found previously for Q-CMV whereas WAII-CMV contains very little RNA 4A in virions. As the 2b gene is conserved in all 10 cucumoviral species or strains sequenced to date and the 2b gene is expressed for three of these viruses, we conclude that the 2b gene is a common feature of the Cucumovirus genus.
Reciprocal Evolution of Opiate Science from Medical and Cultural Perspectives (2017)

Over the course of human history, it has been common to use plants for medicinal purposes, such as for providing relief from particular maladies and self-medication. Opium represents one longstanding remedy that has been used to address a range of medical conditions, alleviating discomfort often in ways that have proven pleasurable. Opium is a combination of compounds obtained from the mature fruit of opium poppy, papaver somniferum. Morphine and its biosynthetic precursors thebaine and codeine constitute the main bioactive opiate alkaloids contained in opium. Opium usage in ancient cultures is well documented, as is its major extract morphine. The presence of endogenous opiate alkaloids and opioid peptides in animals owe their discovery to their consistent actions at particular concentrations via stereo select receptors. In vitro expression of morphine within a microbiological industrial setting underscores the role it plays as a multi-purpose pharmacological agent, as well as reinforcing why it can also lead to long-term social dependence. Furthermore, it clearly establishes a reciprocal effect of human intelligence on modifying evolutionary processes in papaver somniferum and related plant species.
Stimulation of glutamate uptake and Na, K-ATPase activity in rat astrocytes exposed to ischemia-like insults (1997)

The postsynaptic actions of glutamate are rapidly terminated by high affinity glutamate uptake into glial cells. In this study we demonstrate the stimulation of both glutamate uptake and Na,K-ATPase activity in rat astrocyte cultures in response to sublethal ischemia-like insults. Primary cultures of neonatal rat cortical astrocytes were subjected to hypoxia, or to serum- and glucose-free medium, or to both conditions (ischemia). Cell death was assessed by propidium iodide staining of cell nuclei. To measure sodium pump activity and glutamate uptake, 3H-glutamate and 86Rb were both simultaneously added to the cell culture in the presence or absence of 2 mM ouabain. Na,K-ATPase activity was defined as ouabain-sensitive 86Rb uptake. Concomitant transient increases (2-3 times above control levels) of both Na,K-ATPase and glutamate transporter activities were observed in astrocytes after 4-24 h of hypoxia, 4 h of glucose deprivation, and 2-4 h of ischemia. A 24 h ischemia caused a profound loss of both activities in parallel with significant cell death. The addition of 5 mM glucose to the cells after 4 h ischemia prevented the loss of both sodium pump activity and glutamate uptake and rescued astrocytes from death observed at the end of 24 h ischemia. Reoxygenation after the 4 h ischemic event caused the selective inhibition of Na,K-ATPase activity. The observed increases in Na,K-ATPase activity and glutamate uptake in cultured astrocytes subjected to sublethal ischemia-like insults may model an important functional response of astrocytes in vivo by which they attempt to maintain ion and glutamate homeostasis under restricted energy and oxygen supply.
Supplementary Figures 1-3 from Synergistic Activity of the Src Family Kinase Inhibitor Dasatinib and Oxaliplatin in Colon Carcinoma Cells Is Mediated by Oxidative Stress (2023)

Supplementary Figures 1-3 from Synergistic Activity of the Src Family Kinase Inhibitor Dasatinib and Oxaliplatin in Colon Carcinoma Cells Is Mediated by Oxidative Stress