gebhart/patrepeval huggingface dataset:
Neuronal Ca2+ Sensor 1, the Mammalian Homologue of Frequenin, Is Expressed in Chromaffin and PC12 Cells and Regulates Neurosecretion from Dense-core Granules (1998)

Neuronal Ca2+ sensor 1 (NCS-1) is the mammalian homologue of the Ca2+-binding protein frequenin previously implicated in regulation of neurotransmission in Drosophila (Pongs, O., Lindemeier, J., Zhu, X. R., Theil, T., Endelkamp, D., Krah-Jentgens, I., Lambrecht, H.-G., Koch, K. W., Schwemer, J., Rivosecchi, R., Mallart, A., Galceran, J. , Canal, I., Barbas, J. A., and Ferrus, A. (1993) Neuron 11, 15-28). NCS-1 has been considered to be expressed only in neurons, but we show that NCS-1 expression can be detected in bovine adrenal chromaffin and PC12 cells, two widely studied model neuroendocrine cells. NCS-1 was present in both cytosolic and membrane fractions including purified chromaffin granules, and in immunofluorescence, its distribution overlapped with peripheral punctate staining seen with the synaptic-like microvesicle marker synaptophysin in PC12 cells. The possible functional role of NCS-1 in exocytosis of dense-core granules was tested using transient transfection in PC12 cells and assay of co-transfected growth hormone (GH) release. Overexpression of NCS-1 increased evoked GH release in intact cells in response to ATP. No effect of overexpression was seen on GH release because of Ca2+ in permeabilized cells suggesting that NCS-1 may have a regulatory but not direct role in neurosecretion.
Polyphenylene-Based Materials for Organic Photovoltaics (2010)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTPolyphenylene-Based Materials for Organic PhotovoltaicsChen Li†, Miaoyin Liu†, Neil G. Pschirer‡, Martin Baumgarten†, and Klaus Müllen*†View Author Information Max Planck Institute for Polymer Research, Ackermannweg 10, D-55128 Mainz, Germany, and BASF SE, Research Specialty Chemicals, D-67056 Ludwigshafen, Germany* To whom correspondence should be addressed. E-mail: [email protected]†Max Planck Institute for Polymer Research.‡BASF SE.Cite this: Chem. Rev. 2010, 110, 11, 6817–6855Publication Date (Web):June 29, 2010Publication History Received17 February 2010Published online29 June 2010Published inissue 10 November 2010https://pubs.acs.org/doi/10.1021/cr100052zhttps://doi.org/10.1021/cr100052zreview-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views14186Altmetric-Citations613LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Absorption,Aromatic compounds,Hydrocarbons,Polymers,Solar cells Get e-Alerts
Percutaneous gastrostomy: use of intragastric balloon support. (1984)

To facilitate catheter entrance into the stomach during percutaneous gastrostomy, we sutured a balloon to a nasogastric tube and inflated the balloon in the stomach. The balloon provides support and firmness for the compliant stomach, and prevents the gastric wall from being pushed away by incoming needles and catheters. The balloon frequently becomes palpable in the left upper quadrant and offers a good target fluoroscopically or sonographically. Trocar catheters were easier to insert when the target balloon technique was used, and trocar puncture shortened procedure time. The technique initially was developed in the laboratory and then tested in cadavers. Presently it is used with patients. To date, no specific complications have occurred with this procedure.
The endoplasmic reticulum stress response chaperone Gp96, a host receptor for Crohn disease-associated adherent-invasiveEscherichia coli (2011)

Ileal lesions of Crohn disease (CD) patients are abnormally colonized by adherent-invasive Escherichia coli (AIEC) producing outer membrane vesicles (OMVs) that contribute to the bacterial invasion process. In addition, endoplasmic stress was recently reported to have a key role in CD patients after the discovery, in CD patients, of several single nucleotide polymorphisms within gene encoding key component of the ER stress response and of increased expression of ER-localised stress response proteins. We recently demonstrated that the ER-stress response chaperone Gp96 is strongly expressed on the apical surface of ileal epithelial cells in CD patients and acts as a host cell receptor for OMVs, promoting AIEC invasion. In this addendum, we provide a synopsis on current data concerning AIEC virulence, summarize our recent findings and also discuss, in more detail, unresolved issues and the potential implications of our findings.
Hidden Translation Problems in Mono—Cultural Research (1970)

Several years ago. the writer prepared a paper dealing with problems in cross-cultural research [Anderson, 1967]. The translation problem, however, is more ubiquitous than commonly assumed. ... Translation is [potentially] involved whenever research requires asking the 'same' question of people with differing backgrounds. [Ibid., p. 124] This paper will (a) argue that is always a potential problem for sociological research, (b) illustrate the difficulties arising from inattention to the problem in mono-cultural investigations with refer ence to a widely known published research report, and (c) suggest some parallels between techniques for coping with problems in cross-cultural research and those appropriate for mono-cultural use.
Skeletal muscle growth characteristics and myogenic stem cell activity in broiler chickens affected by wooden breast , (2018)

The degenerative myopathy known as wooden breast (WB) has been increasingly observed in the breast muscle (PM) of commercial broilers during the last decade. Previous research has demonstrated that WB may be induced or ameliorated by modulating dietary digestible Lys (dLys) concentrations. Two concurrent experiments (Exp) were conducted to verify the effects of feeding 2 diets formulated to 75% and 100% of recommended dLys concentrations from 15 to 25 d of age on production responses and WB incidence (Exp 1), and the characterization of muscle stem cell activity in broilers affected by WB (Exp 2). At 25 and 43 d of age, birds were injected with 5΄-bromo-2΄-deoxyuridine (BrdU) prior to the collection of PM tissue to label mitotically active cells. Muscle samples were processed for cryosectioning and immunofluorescence staining and microscopy in order to determine myofiber cross-sectional area (CSA), to enumerate Myf-5+ and Pax7+ myogenic stem cell populations, and to determine the mitotic activity (BrdU+) of these populations. The reduced dLys diet produced broilers with differing (P < 0.001) incidences of WB within the same flock (Exp 1), with some detrimental effects on performance and processing characteristics. In Exp 2, broilers with severe WB had increased numbers (P = 0.016) and proportions (P = 0.022) of mitotically active, myogenic stem cells, as well as increased proportions (P < 0.05) of large CSA myofibers relative to broilers unaffected by WB at 25 d of age. At 43 d of age, broilers affected by severe WB had a greater (P = 0.011) total population of myogenic stem cell types (Myf-5+, Pax7+, or Myf-5+:Pax7+) and a concurrent increase (P = 0.007) in the mitotic activity (Myf-5+:BrdU+, and Pax7+:BrdU+, and Myf-5+:Pax7+:BrdU+) of these cells. Additionally, a greater (P < 0.05) proportion of small CSA myofibers was observed in broilers with severe WB. These results provide evidence that myofiber CSA, as well as the heterogeneity and mitotic activity of myogenic stem cell populations were altered in the presence of WB.
CO Ligation Intermediates and the Mechanism of Hemoglobin Cooperativity (1999)

Direct experimental resolution of the ligation intermediates for the reaction of human hemoglobin with CO reveals the distribution of ligated states as a function of saturation. At low saturation, binding of CO occurs with slightly higher affinity to the beta chains, but pairwise interactions are more pronounced between the alpha chains. At high saturation, the two chains tend to behave identically. The sequence of CO ligation reconstructed from the distribution of intermediates shows that the overall increase in CO affinity is 588-fold, but it is not distributed uniformly among the ligation steps. The affinity increases 16.5-fold in the second ligation step, 4.6-fold in the third ligation step, and 7.7-fold in the fourth ligation step. This pattern and the detailed distribution of ligated states cannot be immediately reconciled with the predictions of either the concerted allosteric model of Monod-Wyman-Changeux or the sequential model of Koshland-Nemethy-Filmer and underscore a more subtle mechanism for hemoglobin cooperativity.
Les Basses-Alpes, leur avenir. Comité d'expansion économique des Basses-Alpes. Digne 1963 (1965)

Barbier Bernard. Les Basses-Alpes, leur avenir. Comite d'expansion economique des Basses-Alpes. Digne 1963. In: Mediterranee, 6ᵉ annee, n°4, 1965. pp. 313-314.
K대학 소아치과에 내원한 장애인의 구강진료 실태 (2009)

The purpose of this study was to examine the state of dental treatment among disabled patients by the type of disability. After the medical records of 531 disabled patients who received treatment at the pediatric dentistry in K university hospital, the following findings were given: 1. As for age distribution by year, the rate of patients aged 10 or down rose to 42.5 from 5.1 percent, and the 16-20 age group increased from 16.7 to 24.8 percent. But the rates of patients aged between 11 and 15 and aged 21 and up were on the rise(P<.05). 2. Concerning the type of disability by year, there was an increase in the number of patients with brain lesions, mental retardation, developmental disorder and Down`s syndrome(P<.05). As to the number of dental caries by the type of disability, the patients with heart diseases had the most dental caries that numbered 8.49, followed by Down`s syndrome, metal retardation, brain lesions, the other disabilities and developmental disorder. 3. In relation to dental treatment experiences by the type of disability, the patients with developmental disorder(57.5%) received the most dental treatment, followed by mental retardation, the other disabilities, brain lesions, Down`s syndrome and heart diseases(P<.05). 4. Regarding general anesthesia experience by the type of disability, the patients with mental retardation(31.6%) were put under general anesthesia the most, followed by developmental disorder, brain lesions, the other disabilities, heart diseases and Down`s syndrome(P<.05). In conclusion, nationwide efforts to nurture separate dental personnels responsible for the disabled, to expand relevant facilities and to improve the health care insurance are required to promote the oral health of disabled children.
Variation of nonexchangeable proton resonance chemical shifts as a probe of aberrant base pair formation in DNA (1986)

Variation of nonexchangeable proton resonance chemical shifts for deoxycytidine and deoxy-adenosine as a function of protonation and imino tautomer formation has been determined. Protonation induces downfield shifts of proton resonances whereas formation of the rare imino tautomer induces upfield shifts. Titration curves are constructed on the basis of spectrophotometrically determined pK values. Excellent fit is obtained between theoretical titration curves and experimental data, which indicates that chemical shifts of base protons may be used to quantitatively determine the relative concentrations of either rare imino tautomeric conformations or protonated base forms. These data may be utilized as an aid in the elucidation of the nature of hydrogen bonding between mismatched base pairs in DNA oligomers containing cytosine or adenine residues. These data, in conjunction with the oligonucleotide study of Patel et al. [Patel, D. J., Kozlowski, S.A., Ikuta, S., & Itakura, K. (1984) Biochemistry 23, 3218-3226], have been used to rigorously argue the existence of a "protonated" adenine residue in the A-C mismatch. This structure allows reconciliation of the NMR solution data with crystallographic data [Hunter, W.N., Brown, T., Anand, N.N., & Kennard, O. (1986) Nature (London) 320, 552-555], which support the protonated base pair.
Mid-infrared narrowband polarization management with Al doped ZnO-ZnWO4 eutectic composites (2022)

We report a narrowband polarization-dependent reflectivity from Al-doped ZnO/ZnWO4 self-assembled eutectic composites in the mid-infrared range. Our results show a reflectivity modulation from 0.05 to 0.75 for two orthogonal polarizations of the incident field with a 10% Al concentration. Acting as natural polarizing filters these eutectic composites could open the way to the future development of low-cost photonics components in the IR.
Structure and Rheology of Dense Micelles Suspensions Formed by Hydrophobically End-capped PEO (2008)

The structure and the rheology of polymeric micelles in aqueous solution were studied using dynamic and static light scattering, small angle X‐ray scattering and oscillatory shear rheology. The polymeric micelles were formed by association of poly(ethylene oxide) end‐capped with alkyl group. These systems show a discontinuous jamming transition and form liquid crystalline domains at high concentrations and low temperatures. The effect of adding linear chains or varying the length of the PEO chain or the alkyl end‐group on the liquid‐solid transition will be discussed.
New approach for treatment of prolonged postoperative pain: APS Out-Patient Clinic (2016)

The first two years of the APS-OPC have shown that a significant number of surgical patients benefit from continuing active pain management after discharge from hospital. This fast-track service provides physician-supervised titration of analgesics to improve pain relief in the subacute phase. An important task of the APS-OPC is to ensure that strong opioids are not inappropriately continued after recovery. Another goal of the APS-OPC is to identify patients in need of multidisciplinary pain management services to prevent chronification.
Accurate and automated classification of protein secondary structure with PsiCSI (2003)

PsiCSI is a highly accurate and automated method of assigning secondary structure from NMR data, which is a useful intermediate step in the determination of tertiary structures. The method combines information from chemical shifts and protein sequence using three layers of neural networks. Training and testing was performed on a suite of 92 proteins (9437 residues) with known secondary and tertiary structure. Using a stringent cross-validation procedure in which the target and homologous proteins were removed from the databases used for training the neural networks, an average 89% Q3 accuracy (per residue) was observed. This is an increase of 6.2% and 5.5% (representing 36% and 33% fewer errors) over methods that use chemical shifts (CSI) or sequence information (Psipred) alone. In addition, PsiCSI improves upon the translation of chemical shift information to secondary structure (Q3 = 87.4%) and is able to use sequence information as an effective substitute for sparse NMR data (Q3 = 86.9% without (13)C shifts and Q3 = 86.8% with only H(alpha) shifts available). Finally, errors made by PsiCSI almost exclusively involve the interchange of helix or strand with coil and not helix with strand (<2.5 occurrences per 10000 residues). The automation, increased accuracy, absence of gross errors, and robustness with regards to sparse data make PsiCSI ideal for high-throughput applications, and should improve the effectiveness of hybrid NMR/de novo structure determination methods. A Web server is available for users to submit data and have the assignment returned.
Coagulation et risque vasculaire artériel (2005)

Auteur(s) :, Ludovic Drouet Service d’hematologie biologique, hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris cedex 10 Risque vasculaire arteriel, atherothrombose Au niveau veineux, les evenements thrombotiques font intervenir en priorite la coagulation (et la fibrinolyse), et plus accessoirement les plaquettes. Certaines modifications hormonales peuvent augmenter les facteurs de coagulation ou diminuer les facteurs inhibiteurs, augmentant ainsi le risque thrombotique et thromboembolique [...]
Cupric Ion Reducing Antioxidant Capacity Assay for Food Antioxidants: Vitamins, Polyphenolics, and Flavonoids in Food Extracts (2008)

Antioxidants are health beneficial compounds through their combat with reactive oxygen and nitrogen species and free radicals that may cause tissue damage leading to various diseases. This work reports the development of a simple and widely applicable antioxidant capacity index for dietary polyphenols, vitamins C and E, and plasma antioxidants utilizing the copper(II)-neocuproine (Cu(II)-Nc) reagent as the chromogenic oxidizing agent. This novel method based on an electron-transfer mechanism was named by our research group as 'cupric reducing antioxidant capacity', abbreviated as the CUPRAC method. The method is comprised of mixing the antioxidant solution with aqueous copper(II) chloride, alcoholic neocuproine, and ammonium acetate aqueous buffer at pH 7, and subsequently measuring the developed absorbance at 450 nm after 30 min. Since the color development is fast for compounds like ascorbic acid, gallic acid, and quercetin but slow for naringin and naringenin, the latter compounds are assayed after incubation at 50 degrees C on a water bath for 20 min. The flavonoid glycosides are hydrolyzed to their corresponding aglycones by refluxing in 1.2 M: HCl-containing 50% MeOH so as to exert maximal reducing power towards Cu(II)-Nc. The CUPRAC antioxidant capacities of synthetic mixtures are equal to the sum of individual capacities of antioxidant constituents, indicating lack of chemical deviations from Beer's law. Tests on antioxidant polyphenols demonstrate that the highest CUPRAC capacities are observed for epicatechin gallate, epigallocatechin gallate, quercetin, fisetin, epigallocatechin, catechin, and caffeic acid in this order, in accord with the number and position of the -OH groups as well the conjugation level of the molecule. The parallelism of the linear calibration curves of pure antioxidants in water and in a given complex matrix (plant extract) demonstrates that there are no chemical interactions of interferent nature among the solution constituents, and that the antioxidant capacities of the tested antioxidants are additive, in conformity to the Beer's law. For individual determination of ascorbic acid in fruit juices with a modified CUPRAC procedure, flavonoids are pre-extracted as their La(III) complexes prior to assay. For apricot extracts, a modified version of the CUPRAC assay based on anion exchange separation at pH 3 is applied, since sulfited-dried sample extracts contain the hydrosulfite anion interfering with the determination. For herbal tea infusions, the standard CUPRAC protocol is applied. The CUPRAC reagent is stable, easily accessible, low-cost, and is sensitive toward thiol-type antioxidants unlike FRAP. The reaction is carried out at nearly physiological pH as opposed to the acidic pH of FRAP or to the alkaline pH of Folin methods, constituting a basic advantage for the realistic assay of biological fluids.
Resonance Raman evidence for the interconversion between an [FeIII–η1-OOH] 2+ and [FeIII–η2-O2]+ species and mechanistic implications thereof (1999)

The deprotonation of [FeIII(N4Py)(η1-OOH)]2+ 1 gives [FeIII(N4Py)(η2-OO)]+ 2, as unequivocally demonstrated by resonance Raman spectroscopy, and leads to the loss of alkane hydroxylation activity by 1.
Obstacle avoidance for a power line inspection robot (2012)

This paper presents an obstacle avoidance solution for an existing power line inspection robot (PLIR) prototype. The PLIR's workspace environment is represented by a discretised 3D map, which is used for obstacle avoidance manoeuvre planning for both known and unknown obstacles. Obstacles are represented in this workspace using a union of axis aligned bounding boxes. The Lazy Theta* algorithm is then used to find the shortest 3D graph path around the obstacle. The resulting path nodes are used to generate a B-spline trajectory. The trajectory is simulated to check for collisions and, if collision free, is used to command the actual robot. Experimental results show that this obstacle avoidance strategy is successful, with the prototype robot being able to manoeuvre around an obstacle in laboratory tests.
How the pharmacokinetics and receptor-binding profile of lurasidone affect the clinical utility and safety of the drug in the treatment of schizophrenia (2015)

Lurasidone may be more effective and/or better tolerated than other antipsychotics by some patients although there is currently no way to identify which patients will best respond to which antipsychotic medication. Data from clinical trials of lurasidone in schizophrenia suggest a lower likelihood of weight gain and metabolic problems in patients being treated with lurasidone versus olanzapine and quetiapine.
Berberine Encapsulated Lecithin–Chitosan Nanoparticles as Innovative Wound Healing Agent in Type II Diabetes (2021)

The aim of this research is to formulate a lecithin-chitosan based nanoparticulate system loaded with berberine (BER-LC-CTS-NPs) that could be integrated into a topically applied formulation and assessed for healing wounds in a diabetic animal model. In order to formulate BER-LC-CTS-NPs, soybean lecithin, isopropyl myristate, and berberine dispersed in ethanolic solution were added into an aqueous solution of chitosan dropwise with sonication. We assessed the influence of lecithin amount, chitosan amount, and isopropyl myristate concentration on particle diameter, zeta potential, and entrapment and employed a Box-Behnken statistical design. The resulting optimized BER-LC-CTS-NPs had a mean size of 168.4 nm, a surface charge of 33.1 mV, and entrapment of 82.3%. The optimized BER-LC-CTS-NPs showed a sustained in vitro release profile. Furthermore, the potential of the optimized BER-LC-CTS-NPs integrated into a topical gel formulation for wound healing in streptozocin-induced diabetic rats was assessed. Our findings show that combining chitosan and berberine in the nanoparticles produces a synergistic effect when it comes to wound healing. The optimized nanoparticulate system works by reducing inflammation, inducing blood vessels and fibroblast proliferation, and promoting mature collagen fibers deposition. Based on the experimental results, lecithin-chitosan nanoparticles loaded with berberine have evolved as a promising strategy for accelerating wound the healing process in diabetic patients. However, the clinical merits of the developed system need to be investigated in diabetic patients.
SARSIM and SARSIM+: data-bases for the development of SAR Tomography in forestry applications (2019)

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