gebhart/patrepeval huggingface dataset:
[Experience with divicor used in type 2 diabetes]. (2007)

The purpose of this publication is to acquaint a wide circle of doctors (therapists, endocrinologists, diabetologists, cardiologists, etc.) with the new domestic metabolic drug dibicor, which can restore the metabolism in the body and positively affect both diabetes and cardiovascular pathology.
Supplementary Methods, Legends for Videos and Figures from Improved Cellular Pharmacokinetics and Pharmacodynamics Underlie the Wide Anticancer Activity of Sagopilone (2023)

Supplementary Methods, Legends for Videos and Figures from Improved Cellular Pharmacokinetics and Pharmacodynamics Underlie the Wide Anticancer Activity of Sagopilone
T-cells of multiple myeloma patients triggered by the autologous mixed lymphocyte reaction suppress polyclonal immunoglobulin synthesis (1988)

To elucidate the possible role of T-cells of patients with multiple myeloma (MM) in the suppression of polyclonal immunoglobulin synthesis. T-cells with and without prior activation by the autologous mixed lymphocyte reaction (AMLR) were added to normal immunoglobulin (Ig)-secreting cultures. The suppression induced by AMLR-activated T-cells from patients with MM was compared to that induced by AMLR-activated T-cells from apparently normal controls. The addition of 10% unstimulated autologous T-cells from patients with MM resulted in minimal suppression of IgG synthesis (87 +/- 19% of baseline values for patients and 115 +/- 21% for controls, no significant difference). The suppression sharply increased when T-cells were preactivated by AMLR and then added in the same concentration to the IgG-secreting cultures (38 + 12% of baseline values for patients compared to 106 + 14% for controls, P less than 0.05). AMLR cultures were performed in the presence of adherent monocytes and after their depletion. The T-cell suppressor effect on normal IgG synthesis was unchanged after monocyte depletion. T-cells preactivated in the AMLR from patients with MM sharply suppress in vitro polyclonal IgG synthesis, and the activation of these suppressor T-cells is not dependent on the presence of monocytes.
PET Tracers Based on Zirconium-89 (2011)

Positron emission tomography (PET) imaging with radiolabeled monoclonal antibodies has always been a dynamic area in molecular imaging. With decay half-life (3.3 d) well matched to the circulation half-lives of antibodies (usually on the order of days), (89)Zr has been extensively studied over the last decade. This review article will give a brief overview on (89)Zr isotope production, the radiochemistry generally used for (89)Zr-labeling, and the PET tracers that have been developed using (89)Zr. To date, (89)Zr-based PET imaging has been investigated for a wide variety of cancer-related targets, which include human epidermal growth factor receptor 2, epidermal growth factor receptor, prostate-specific membrane antigen, splice variant v6 of CD44, vascular endothelial growth factor, carbonic anhydrase IX, insulin-like growth factor 1 receptor, among others. With well-developed radiochemistry, commercial availability of chelating agents for (89)Zr labeling, increasingly widely available isotope supply, as well as successful proof-of-principle in pilot human studies, it is expected that PET imaging with (89)Zr-based tracers will be a constantly evolving and highly vibrant field in the near future.
Medical malpractice and sarcoma care-A thirty-three year review of case resolutions, inciting factors, and at risk physician specialties surrounding a rare diagnosis (2014)

Reported medico-legal claims involving sarcoma care continue to rise, with mean indemnity payments approaching 10 times that for other reported medical/surgical specialties. Primary care and orthopaedic specialties are the most commonly named physician defendants, citing a delay in diagnosis. This suggests further education in the front line diagnosis and management of sarcomas is needed.
Whole blood assay as a model for in vitro evaluation of inflammasome activation and subsequent caspase-mediated interleukin-1 beta release (2019)

Processing of pro-interleukin (IL)-1β and IL-18 is regulated by multiprotein complexes, known as inflammasomes. Inflammasome activation results in generation of bioactive IL-1β and IL-18, which can exert potent pro-inflammatory effects. Our aim was to develop a whole blood-based assay to study the inflammasome in vitro and that also can be used as an assay in clinical studies. We show whole blood is a suitable milieu to study inflammasome activation in primary human monocytes. We demonstrated that unprocessed human blood cells can be stimulated to activate the inflammasome by the addition of adenosine 5'-triphosphate (ATP) within a narrow timeframe following lipopolysaccharide (LPS) priming. Stimulation with LPS resulted in IL-1β release; however, addition of ATP is necessary for "full-blown" inflammasome stimulation resulting in high IL-1β and IL-18 release. Intracellular cytokine staining demonstrated monocytes are the major producers of IL-1β in human whole blood cultures, and this was associated with activation of caspase-1/4/5, as detected by a fluorescently labelled caspase-1/4/5 probe. By applying caspase inhibitors, we show that both the canonical inflammasome pathway (via caspase-1) as well as the non-canonical inflammasome pathway (via caspases-4 and 5) can be studied using this whole blood-based model.
[The Marshall-Marchetti operation]. (1974)

25 cases of women's stress incontinence surgically treated using the Marshall Marchetti's procedure are analysed. One year after the operation the definitive results were evaluated. In this series 80% of the cases improved and 70% were definite successes. The advantages and disadvantages of the procedure are discussed.
Large‐scale identification of genes in the fungus Hebeloma cylindrosporum paves the way to molecular analyses of ectomycorrhizal symbiosis (2004)

• In an attempt to advance the understanding of ectomycorrhizal symbiosis, which improves mineral nutrition and resistance to abiotic and biotic stresses of most woody plants from temperate and boreal regions, we produced a cDNA library of the ectomycorrhizal fungus Hebeloma cylindrosporum in a yeast expression vector. The library was used for functional complementation cloning and for sequencing of 4036 expressed sequence tags (ESTs). • Expression of the library in a yeast ade2 and trp1 mutant strain allowed cloning of two Hebeloma genes, HcADE2 and HcTRP1 by functional complementation. This experiment highlighted both the efficiency of the complementation strategy and the quality of the library. • All sequence data available on Hebeloma (4596) were analysed and contiged. The whole EST resource is accessible via a web interface, which allows searching and navigation through clusters and tentative contigs (TCs). • Analysis of the database revealed a low level of counterparts already identified in other ectomycorrhizal fungi. For example, it allowed identification of a large set of membrane transporters, such as phosphate, potassium, sulphate or micronutrient transporters. Thus, this EST resource provides a valuable tool for research on ectomycorrhiza and symbiotic interactions.
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage (2021)

Smooth muscle is an essential component of the intestine, both to maintain its structure and produce peristaltic and segmentation movements. However, very little is known about other putative roles that smooth muscle cells may have. Here, we show that smooth muscle cells may be the dominant suppliers of BMP antagonists, which are niche factors essential for intestinal stem cell maintenance. Furthermore, muscle-derived factors render epithelium reparative and fetal-like, which includes heightened YAP activity. Mechanistically, we find that the membrane-bound matrix metalloproteinase MMP17, which is exclusively expressed by smooth muscle cells, is required for intestinal epithelial repair after inflammation- or irradiation-induced injury. Furthermore, we propose that MMP17 affects intestinal epithelial reprogramming after damage indirectly by cleaving diffusible factor(s) such as the matricellular protein PERIOSTIN. Together, we identify an important signaling axis that establishes a role for smooth muscle cells as modulators of intestinal epithelial regeneration and the intestinal stem cell niche.
Transgenic Expression of RasGRP1 Induces the Maturation of Double-Negative Thymocytes and Enhances the Production of CD8 Single-Positive Thymocytes (2003)

RasGRP1 is a guanine nucleotide exchange factor for Ras that is required for the efficient production of both CD4 and CD8 single-positive thymocytes. We found that RasGRP1 expression is rapidly up-regulated in double-negative thymocytes following pre-TCR ligation. Transgenic overexpression of RasGRP1 compensated for deficient pre-TCR signaling in vivo, enabling recombinase-activating gene 2(-/-) double-negative thymocytes to mature to the double-positive stage. RasGRP1 transgenic mice had a 4-fold increase in CD8 single-positive thymocytes, most of which had atypically low levels of CD3. The RasGRP1 transgene lowered the threshold of TCR signaling needed to initiate proliferation of single-positive thymocytes, with this effect being particularly evident among CD8 single-positive cells. In 3-day cultures, TCR stimulation via anti-CD3 caused a 10-fold increase in the ratio of CD8 to CD4 thymocytes among RasGRP1 transgenic vs nontransgenic thymocytes. These results demonstrate that in addition to driving the double-negative to double-positive transition, increased expression of RasGRP1 selectively increases CD8 single-positive thymocyte numbers and enhances their responsiveness to TCR signaling.
Coronary Heart Disease in Smokers (2000)

The present study is the first to demonstrate that the noxious prooxidant effects of smoking extend beyond the epicardial arteries to the coronary microcirculation and affect the regulation of myocardial blood flow. Vitamin C restores coronary microcirculatory responsiveness and impaired coronary flow reserve in smokers, which provides evidence that the damaging effect of smoking is at least in part accounted for by an increased oxidative stress.
Ni-Catalyzed Conversion of Enol Triflates to Alkenyl Halides (2019)

A Ni-catalyzed halogenation of alkenyl triflates was developed that enables the synthesis of a broad range of alkenyl iodides, bromides, and chlorides under mild reaction conditions. The reaction utilizes inexpensive, bench stable Ni(OAc)&lt;sub&gt;2&lt;/sub&gt;•4H&lt;sub&gt;2&lt;/sub&gt;O as a pre-catalyst and proceeds at room temperature in the presence of sub-stoichiometric Zn and either cod or DMAP as a supporting ligand.
Revisiting The Evaluation of Class Activation Mapping for Explainability: A Novel Metric and Experimental Analysis (2021)

As the request for deep learning solutions increases, the need for explainability is even more fundamental. In this setting, particular attention has been given to visualization techniques, that try to attribute the right relevance to each input pixel with respect to the output of the network. In this paper, we focus on Class Activation Mapping (CAM) approaches, which provide an effective visualization by taking weighted averages of the activation maps. To enhance the evaluation and the reproducibility of such approaches, we propose a novel set of metrics to quantify explanation maps, which show better effectiveness and simplify comparisons between approaches. To evaluate the appropriateness of the proposal, we compare different CAM-based visualization methods on the entire ImageNet validation set, fostering proper comparisons and reproducibility.
Shape memory performance of green in situ polymerized nanocomposites based on polyurethane/graphene nanoplatelets: Synthesis, properties, and cell behavior (2017)

Nowadays, developing biocompatible shape memory polymers is among major expanding topics in medical applications. In this study, novel biocompatible polyurethane/graphene nanoplatelet (PU/GNp) nanocomposites were synthesized from poly(ε–caprolactone)diol (PCL diol)/Castor oil and Hexamethylene diisocyanate (HDI) through in situ polymerization. Three different %wt. of GNp were incorporated into the polyol mixtures to monitor the effect of nano fillers on the shape memory behavior of PUs. The chemical structure of nanocomposites was studied by Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopies. X‐ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and differential scanning calorimetry (DSC) were used to evaluate the nanocomposites properties. GNp incorporation affected the bulk morphology as well as thermal properties and crystallinity. Dynamic mechanical thermal analysis (DMTA) revealed the higher elastic modulus values for nanocomposites compared to the pure PU. The biocompatibility of PU/GNp nanocomposites was investigated via MTT assay. Finally, based on shape memory studies, the higher crystallinity, and improved elastic modulus of the nanocomposites resulted in their excellent shape fixity (about 91‐96%) and shape recovery (95‐99%) behaviors. According to the results, the prepared PU/GNp nanocomposites can be considered as potential choices for applicable shape memory devices for biomedical applications. POLYM. COMPOS., 39:4020–4033, 2018. © 2017 Society of Plastics Engineers
Metronomic oral maintenance chemotherapy in patients with localized high-risk rhabdomyosarcoma (RMS) and RMS-like tumors: A report from a randomized, multicenter, phase III trial CWS-2007HR. (2022)

10033 Background: Low dose maintenance therapy as consolidation after multimodal standard therapy has been shown to improve survival in patients with sarcoma. It is however unclear which drugs and how long would be optimal. We investigated whether adding oral maintenance chemotherapy after standard multimodal therapy (ST) in patients with localized RMS and RMS-like sarcoma defined as high and very-high risk (HR and VHR), according to CWS stratification, would improve survival. Methods: Patients (pts) age &gt; 6 months &lt; 21 years, with 1. embryonal RMS N0, incompletely resected, (Group II or III), tumor size &gt; 5cm and/or ≥10 years, in unfavorable primary sites and all N1 (HR RMS Group), 2. alveolar RMS N0/N1 (VHR RMS Group) 3.Unidfferentiated sarcoma (UDS), extraskeletal Ewing sarcoma (EES) and primary non resectable (Group III) synovial sarcoma (SS) (HR RMS-like Group) in complete remission after ST including 9 cycles of ifosfamide, vincristine and actinomycin D +/- doxorubicin, surgery and/or radiotherapy were eligible for randomization to stop treatment (S-arm) or receive maintenance chemotherapy (M-arm) with eight 10-days courses consisting of trofosfamide (2x 75mg/m²/day) and idarubicine (1 x 5mg/m²/day 1,4,7,10) alternating with trofosfamide and etoposide (2x 25mg/m²/day). The study was designed with 80% power and a two-sided alpha level of 5% to detect an increase in 3 yr EFS from 60 to 75%. Randomisation was stratified according to risk groups. To reduce possible imbalances in the number of treatment assignments, a permuted block design was used. The initial calculated sample size was 145 pts in each group (recruitment period six years). Due to the lower than planned recruitement rate, the accrual was extended to 10 years and sample size recalculated to 98 pts in each group. Results: Between 1.7.2009 and 30.6.2019, 441 pts were eligible at diagnosis and 337 at the end of ST. 195 pts were randomized: 99 were assigned to the S-arm and 96 to M-arm. The distribution of the following clinical features:age, gender, tumor size, IRS-Group, T-Status, N-Status, histology and localisation showed no significant difference between the treatment groups. In the intent to treat population, with a median follow up of 4.9 years (IQR 3.0-5.7) in surviving pts, 3yr EFS and OS in M-arm vs S-arm were respectively: EFS 66.2% (95% IC 57.1-76.79) vs 75.0% (95% IC 66.8-84.3) (p 0.07) and OS 81.9% (95% IC 74.2-90.4) vs 84.6 (95% IC 77.5-92.4) (p 0.15). Toxicity grade 3 (no grade 4) in the M-arm was: hematological in 51 %, febrile infection 5%, sensory neuropathy in 1% pts. Conclusions: The addition of maintenance therapy with trofosfamide, etoposide and idarubicine after ST does not improve EFS and OS in patients with high risk RMS and RMS-like sarcomas. Clinical trial information: 2007-0001478-10.
Machine Learning Approach to Predict the Probability of Recurrence of Renal Cell Carcinoma After Surgery: Prediction Model Development Study (Preprint) (2020)

<sec> <title>BACKGROUND</title> Renal cell carcinoma (RCC) has a high recurrence rate of 20% to 30% after nephrectomy for clinically localized disease, and more than 40% of patients eventually die of the disease, making regular monitoring and constant management of utmost importance. </sec> <sec> <title>OBJECTIVE</title> The objective of this study was to develop an algorithm that predicts the probability of recurrence of RCC within 5 and 10 years of surgery. </sec> <sec> <title>METHODS</title> Data from 6849 Korean patients with RCC were collected from eight tertiary care hospitals listed in the KOrean Renal Cell Carcinoma (KORCC) web-based database. To predict RCC recurrence, analytical data from 2814 patients were extracted from the database. Eight machine learning algorithms were used to predict the probability of RCC recurrence, and the results were compared. </sec> <sec> <title>RESULTS</title> Within 5 years of surgery, the highest area under the receiver operating characteristic curve (AUROC) was obtained from the naïve Bayes (NB) model, with a value of 0.836. Within 10 years of surgery, the highest AUROC was obtained from the NB model, with a value of 0.784. </sec> <sec> <title>CONCLUSIONS</title> An algorithm was developed that predicts the probability of RCC recurrence within 5 and 10 years using the KORCC database, a large-scale RCC cohort in Korea. It is expected that the developed algorithm will help clinicians manage prognosis and establish customized treatment strategies for patients with RCC after surgery. </sec>
A simple soft lithographic route to fabricate pre-textured nanopatterns on aluminum surfaces and one-step anodization for highly-ordered nanoporous alumina templates (2013)

A time- and cost-effective fabrication process for uniformly well-ordered anodic alumina templates was newly suggested. Pre-textured nanopatterns on aluminum sheets as the pore initiation site were fabricated by using soft lithographic methods and selective inductively coupled plasma etching. Then, only a one-step anodization was performed for the preparation of a regular nanoporous alumina template. As a result, a well-ordered nanoporous alumina template was prepared with an obvious barrier layer on the aluminum substrate. Especially, this type of innovative fabrication strategy can be easily generalized to facilitate other valve metal anodization processes.
Cell adhesion properties of myelin‐associated glycoprotein in L cell fibroblasts (1991)

Myelin-associated glycoprotein (MAG) is a cell surface molecule expressed by oligodendrocytes and Schwann cells. In order to determine whether MAG expression can confer adhesive properties to cells which normally do not aggregate in suspension, the cDNA encoding the long form of MAG (L-MAG) was introduced into L cell fibroblasts by retroviral infection. Clonal L cell lines expressing MAG were then subjected to a cell aggregation assay. Our results indicate that L-MAG can function as an intercellular adhesion molecule in a heterologous cell system. A critical threshold value of L-MAG expression was required for cell aggregation to occur. The adhesive properties of these cells were specific to MAG, since monoclonal antibodies directed against its extracellular domain inhibited aggregation. Furthermore, the adhesion was found to be calcium- and temperature-independent. Cell sorting experiments demonstrated that L-MAG-expressing cells bind in a heterotypic fashion to parental L cell fibroblasts. These results suggest that L-MAG can function as a heterotypic cell adhesion molecule recognizing a cell surface molecule(s) expressed by L cells.
A modular location-aware service and application platform (2003)

Location-aware applications for supporting the mobile user as well as logistics of movable objects have proven to be of significant relevance for future telecommunication and computing. Based on a state-of-the-art analysis, the paper evaluates the outcome of laboratories and the requirements of commercial usage. A system architecture is proposed from the technical perspective for localisation, information, communication, and management. The required support of heterogeneous resources leads to the necessity of an adequate middleware platform. The location-aware service and application platform provides modular unified access to various services, which are commonly and overlappingly used by multiple applications. Service request trading assigns the appropriate in-house services or third-party providers to the requirements of the applications. Merging data from different sources and constraints in the transmission and presentation capabilities of the mobile side require sophisticated media scaling and conversion capabilities. The envisaged service architecture leads finally to the discussion of a number of prototype applications developed and being developed on our test-bed.
Über Thiazole, XLIV. Die Synthese von 1‐[Thiazolyl‐(2)]‐imidazolonen‐(2) (1966)

Abstract 1‐Cyan‐imidazolone‐(2) ( 1 ) addieren Schwefelwasserstoff unter Bildung der entsprechend substituierten 1‐Thiocarbamoyl‐imidazolone‐(2) ( 2 ), die mit aromatischen α‐Halogenketonen 1‐[Thiazolyl‐(2)]‐imidazolone‐(2) ( 3 ) bilden. — Die Addition von Phenylhydrazin an 1‐Cyan‐imidazolone‐(2) führt zu den betreffenden 1‐Anilinoguanyl‐imidazolonen‐(2) ( 4 ).
Semblance criterion modification to incorporate signal energy threshold (2009)

The semblance criterion widely used for slowness estimation is examined using the theory of statistical hypothesis testing and shown to be equivalent to that for detecting propagating signals of any energy at a specified slowness. We propose to suppress weak collar arrivals on semblance maps for logging while drilling (LWD) data by incorporating a minimum signal energy threshold in the aforementioned theory and using it to derive a couple of modifications of the semblance. Other simpler modification inspired by these are also proposed on heuristic grounds. All proposed modifications perform comparably on real LWD data and are effective at suppressing weak unwanted arrivals while preserving the desired ones.
MUSIC, maximum likelihood, and Cramer-Rao bound (1989)

The performance of the MUSIC and ML methods is studied, and their statistical efficiency is analyzed. The Cramer-Rao bound (CRB) for the estimation problems is derived, and some useful properties of the CRB covariance matrix are established. The relationship between the MUSIC and ML estimators is investigated as well. A numerical study is reported of the statistical efficiency of the MUSIC estimator for the problem of finding the directions of two plane waves using a uniform linear array. An exact description of the results is included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>