gebhart/patrepeval huggingface dataset:
L’identité professionnelle de pêcheurs à l’épreuve de la protection de la biodiversité. Exemple des pêcheurs de Martinique (2022)

Cet article apporte un éclairage sur les défis socio-professionnels de l’écologisation des politiques publiques française et européenne dans les Territoires Outre-Mer. Il présente l’effet de la création d’une Aire Marine Protégée (AMP) sur l’identité professionnelle de pêcheurs traditionnels. La recherche, menée dans une perspective sociologique au Prêcheur, commune de la Martinique, contribue, de manière inédite, à fournir des éléments d’analyse sur la posture professionnelle des pêcheurs vis-à-vis d’un tel mécanisme de protection des écosystèmes marins qui remet en cause leur identité et leur survie. L’enjeu de la protection de la biodiversité se heurte ainsi à celui de la préservation des intérêts catégoriels et identitaires.
68Ga-PSMA-11 PET/CT Mapping of Prostate Cancer Biochemical Recurrence After Radical Prostatectomy in 270 Patients with a PSA Level of Less Than 1.0 ng/mL: Impact on Salvage Radiotherapy Planning (2017)

Target volume delineations for prostate cancer (PCa) salvage radiotherapy (SRT) after radical prostatectomy are usually drawn in the absence of visibly recurrent disease. <sup>68</sup>Ga-labeled prostate-specific membrane antigen (PSMA-11) PET/CT detects recurrent PCa with sensitivity superior to standard-of-care imaging at serum prostate-specific antigen (PSA) values low enough to affect target volume delineations for routine SRT. Our objective was to map the recurrence pattern of PCa early biochemical recurrence (BCR) after radical prostatectomy with <sup>68</sup>Ga-PSMA-11 PET/CT in patients with serum PSA levels of less than 1 ng/mL, determine how often consensus clinical target volumes (CTVs) based on the Radiation Therapy Oncology Group (RTOG) guidelines cover <sup>68</sup>Ga-PSMA-11 PET/CT-defined disease, and assess the potential impact of <sup>68</sup>Ga-PSMA-11 PET/CT on SRT. <b>Methods:</b> This was a post hoc analysis of an intention-to-treat population of 270 patients who underwent <sup>68</sup>Ga-PSMA-11 PET/CT at 4 institutions for BCR after prostatectomy without prior radiotherapy at a PSA level of less than 1 ng/mL. RTOG consensus CTVs that included both the prostate bed and the pelvic lymph nodes were contoured on the CT dataset of the PET/CT image by a radiation oncologist masked to the PET component. <sup>68</sup>Ga-PSMA-11 PET/CT images were analyzed by a nuclear medicine physician. <sup>68</sup>Ga-PSMA-11-positive lesions not covered by planning volumes based on the consensus CTVs were considered to have a potential major impact on treatment planning. <b>Results:</b> The median PSA level at the time of <sup>68</sup>Ga-PSMA-11 PET/CT was 0.48 ng/mL (range, 0.03-1 ng/mL). One hundred thirty-two of 270 patients (49%) had a positive <sup>68</sup>Ga-PSMA-11 PET/CT result. Fifty-two of 270 (19%) had at least one PSMA-11-positive lesion not covered by the consensus CTVs. Thirty-three of 270 (12%) had extrapelvic PSMA-11-positive lesions, and 19 of 270 (7%) had PSMA-11-positive lesions within the pelvis but not covered by the consensus CTVs. The 2 most common <sup>68</sup>Ga-PSMA-11-positive lesion locations outside the consensus CTVs were bone (23/52, 44%) and perirectal lymph nodes (16/52, 31%). <b>Conclusion:</b> Post hoc analysis of <sup>68</sup>Ga-PSMA-11 PET/CT implied a major impact on SRT planning in 52 of 270 patients (19%) with PCa early BCR (PSA < 1.0 ng/mL). This finding justifies a randomized imaging trial of SRT with or without <sup>68</sup>Ga-PSMA-11 PET/CT investigating its potential benefit on clinical outcome.
Serum Bioactive Follicle-Stimulating Hormone-Like Activity in Human Pregnancy Is a Methodological Artifact* (1991)

Serum from pregnant women has been shown to contain both FSH-like and FSH antagonistic activities when measured by an in vitro bioassay based upon FSH-dependent aromatase activity of immature rat Sertoli cells. In the present study we further tested the hypothesis that the FSH-like bioactivity of pregnancy serum was due to an authentic aromatase stimulator. A potent inhibitor of aromatase which completely blocked the FSH action on Sertoli cells had no effect on the bioactivity of pregnancy serum. Experiments using conversion of tritiated testosterone to estradiol showed that the factor did not stimulate aromatase activity in rat Sertoli cells. After incubation with pregnancy serum, equally high amounts of estradiol were measurable in the medium in both the absence and presence of Sertoli cells. The activity was almost completely lost after charcoal treatment or ether extraction of the serum and was shown to probably be due to the release of endogenous estrogens by the carrier proteins in the incubation medium of the Sertoli cell assay. These data suggest that the FSH-like bioactivity in serum from pregnant women is an artifact due to nonspecific interference(s) in the bioassay.
Lymphoid Malignancies (2004)

Abstract Malignant transformation may occur at any point during lymphoid cell maturation, resulting in stage‐ and lineage‐specific cancers of the immune system. Many in‐bred and engineered mouse strains develop specific lymphoid cancers, providing potentially useful models of human malignancy with insight for pathogenetic mechanisms. Newer techniques, targeting dysregulated gene expression to specific developmental stages portend newer, more accurate mouse models in the future. These models will likely have an increasing role in evaluating targeted therapeutic strategies for efficacy.
Chapter 1. Medical Imaging: Overview and the Importance of Contrast (2011)

Significant medical imaging techniques for in vivo use are magnetic resonance imaging (MRI), optical imaging techniques (including fluorescence), X-ray imaging techniques (including X-ray Computed Tomography, CT), gamma imaging techniques (including Single Photon Emission Computed Tomography, SPECT), positron emission tomography (PET), and ultrasound. The key requirement for any useful medical imaging technology is contrast, achieved either through some endogenous physical mechanism, or through the effects of some exogenous chemical agent, that permits one structure in the body to report a different signal than another. This chapter reviews briefly endogenous and exogenous contrast in medical imaging, and discusses how medical imaging is used.
A Novel Normalized Cross-Correlation Based Echo-Path Change Detector (2007)

A double-talk detector is used to freeze acoustic echo canceller's (AEC) filter adaptation during periods of near-end speech. Increased sensitivity towards double-talk results in declaring echo-path changes as double-talk which adversely effects the performance of an AEC as we freeze adaptation when we really need to adapt. Thus, we need an efficient and simple echo-path change detector so as to differentiate any echo-path variations from double-talk condition. In this paper, we derive a novel test statistic for echo-path change detection. The proposed decision statistic detects any echo-path variations, is normalized properly and is computationally very efficient as compared to existing techniques. Simulations demonstrate the efficiency of the proposed algorithm.
Analogues of [3H] Chloramphenicol for Photoaffinity Labeling (1979)

The synthesis of [3H]chloramphenicol and its erythro-diastereoisomer with specific activities of 1.25 Ci/mmol, and the further transformation of the [3H]chloramphenicol to a series of azido and diazo-substituted derivatives are described. The antibiotic activity of the compounds was considered insufficient for their use as photoaffinity labels.
Tool support for just-in-time architecture reconstruction and evaluation: an experience report (2005)

The need for software architecture evaluation has drawn considerable attention. In practice, this is a challenging exercise for two main reasons. First, in deployed projects, software architecture documentation is often not readily available, and may not be a correct representation of the as built architecture. Second, large software systems have numerous potential views of the various architecturally significant structures in the system. In this paper, we assess the capabilities of software reverse engineering and architecture reconstruction tools to support just-in-time architecture reconstruction. If an application's architecture can be reconstructed efficiently, this could promote more effective architecture reviews and evaluations. We describe our experiences in leveraging multiple reconstruction tools and how these guided the choice of design artifacts to construct. We discovered that the tools complemented each other in identifying reconstruction scope, critical architectural elements, potential design irregularities and creating useful architectural views for different evaluation tasks. With the help of these tools, the reconstruction and evaluation effort was significantly streamlined and productive. Finally, we also report some potential improvements these tools could make.
KI-Methoden in der Finanzwirtschaft: grundlegende Fragen, Stand der Forschung, Einsatzpotentiale. (1996)

Available from Bibliothek des Instituts fuer Weltwirtschaft, ZBW, D-21400 Kiel W 829 (1996.7) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische Informationsbibliothek
Lipid nanoparticles for the sustained released of miRNA: new perspectives into intervertebral disc regenerative medicine (2019)

International audience
Estimating genetics of body dimensions and activity levels in pigs using automated pose estimation (2022)

Pig breeding is changing rapidly due to technological progress and socio-ecological factors. New precision livestock farming technologies such as computer vision systems are crucial for automated phenotyping on a large scale for novel traits, as pigs' robustness and behavior are gaining importance in breeding goals. However, individual identification, data processing and the availability of adequate (open source) software currently pose the main hurdles. The overall goal of this study was to expand pig weighing with automated measurements of body dimensions and activity levels using an automated video-analytic system: DeepLabCut. Furthermore, these data were coupled with pedigree information to estimate genetic parameters for breeding programs. We analyzed 7428 recordings over the fattening period of 1556 finishing pigs (Piétrain sire x crossbred dam) with two-week intervals between recordings on the same pig. We were able to accurately estimate relevant body parts with an average tracking error of 3.3 cm. Body metrics extracted from video images were highly heritable (61-74%) and significantly genetically correlated with average daily gain (r<sub>g</sub> = 0.81-0.92). Activity traits were low to moderately heritable (22-35%) and showed low genetic correlations with production traits and physical abnormalities. We demonstrated a simple and cost-efficient method to extract body dimension parameters and activity traits. These traits were estimated to be heritable, and hence, can be selected on. These findings are valuable for (pig) breeding organizations, as they offer a method to automatically phenotype new production and behavioral traits on an individual level.
Efficient Loading of Sulfonamide Safety-Catch Linkers by Fmoc Amino Acid Fluorides (2002)

[reaction: see text] Fmoc-protected amino acid fluorides were found to be excellent reagents for the acylation of sulfonamide safety-catch linkers (SCL) suitable for the subsequent preparation of peptide C-terminal thioesters. High loadings were obtained on different types of resins with low levels of epimerization.
Plasma torque and nonambipolar transport (2009)

Poloidal symmetry breaking in toroidal plasmas causes a damping of poloidal rotation and toroidal symmetry breaking a damping of toroidal rotation. These torques are transmitted by the magnetic field to the outside world. An upper limit exists on the torque that can be transmitted by magnetic asymmetries. This limit is enforced by shielding asymmetries from the plasma, which can be an important effect for toroidal asymmetries. The torque interaction of plasmas with magnetic fields can be either through an anisotropic pressure or by the drive for magnetic islands. The physics of both types of interactions are considered and paradoxical effects are clarified.
Patterns of linkage disequilibrium and association mapping in diploid alfalfa (M. sativa L.) (2012)

Association mapping enables the detection of marker-trait associations in unstructured populations by taking advantage of historical linkage disequilibrium (LD) that exists between a marker and the true causative polymorphism of the trait phenotype. Our first objective was to understand the pattern of LD decay in the diploid alfalfa genome. We used 89 highly polymorphic SSR loci in 374 unimproved diploid alfalfa (Medicago sativa L.) genotypes from 120 accessions to infer chromosome-wide patterns of LD. We also sequenced four lignin biosynthesis candidate genes (caffeoyl-CoA 3-O-methyltransferase (CCoAoMT), ferulate-5-hydroxylase (F5H), caffeic acid-O-methyltransferase (COMT), and phenylalanine amonialyase (PAL 1)) to identify single nucleotide polymorphisms (SNPs) and infer within gene estimates of LD. As the second objective of this study, we conducted association mapping for cell wall components and agronomic traits using the SSR markers and SNPs from the four candidate genes. We found very little LD among SSR markers implying limited value for genomewide association studies. In contrast, within gene LD decayed within 300 bp below an r (2) of 0.2 in three of four candidate genes. We identified one SSR and two highly significant SNPs associated with biomass yield. Based on our results, focusing association mapping on candidate gene sequences will be necessary until a dense set of genome-wide markers is available for alfalfa.
DRM, trusted computing and operating system architecture (2005)

Robust technological enforcement of DRM licenses assumes that the prevention of direct access to the raw bit representation of decrypted digital content and the license enforcement mechanisms themselves is possible. This is difficult to achieve on an open computing platform such as a PC. Recent trusted computing initiatives namely, the Trusted Computing Group (TCG) specification, and Microsoft&amp;apos;s Next Generation Secure Computing Base (NGSCB) aim in part to address this problem. The protection architecture and access control model of mainstream operating systems makes them inappropriate as a platform for a DRM content rendering client because decrypted content cannot be protected against a privileged process. If a DRM client is to be deployed on an open computing platform, the operating system should implement the reference monitor concept, which underpins the mandatory access control model. The TCG model of trusted computing has important limitations when combined with an operating system enforcing discretionary access control. We argue that the TCG services of sealed storage and remote attestation which are important in DRM applications, cannot operate in a secure and efficient manner on such an operating system.
Overexpression of TGF-α increases lung tissue hysteresivity in transgenic mice (2001)

Increased transforming growth factor (TGF)-alpha has been observed in neonatal chronic lung disease. Lungs of transgenic mice that overexpress TGF-alpha develop enlarged air spaces and pulmonary fibrosis compared with wild-type mice. We hypothesized that these pathological changes may alter the mechanical coupling of viscous and elastic forces within lung parenchyma. Respiratory impedance was measured in open-chested, tracheostomized adult wild-type and TGF-alpha mice by using the forced oscillation technique (0.25-19.63 Hz) delivered by flexiVent (Scireq, Montreal, PQ). Estimates of airway resistance (Raw), inertance (I), and the coefficients of tissue damping (G(L)) and tissue elastance (H(L)) were obtained by fitting a model to each impedance spectrum. Hysteresivity (eta) was calculated as G(L)/H(L). There was a significant increase in eta (P < 0.01) and a trend to a decrease in H(L) (P = 0.07) of TGF-alpha mice compared with the wild-type group. There was no significant change in Raw, I, or G(L). Structural abnormality present in the lungs of adult TGF-alpha mice alters viscoelastic coupling of the tissues, as evidenced by a change in eta.
CYP-dependent Metabolism of Antitumor Pyrazolo[3,4-d]pyrimidine Derivatives Is Characterized by an Oxidative Dechlorination Reaction (2014)

The aim of this study is to investigate the metabolic (cytochrome P450-dependent) behaviour of pyrazolo[3,4-d]pyrimidines 1-10 dual Abl/Src kinase inhibitors. All the compounds demonstrate good metabolic stability both in human liver (HLM) and in rat liver (RLM) microsomes. Moreover, all the tested molecules undergo the same metabolic CYP-dependent reactions, namely oxidative dechlorination and N-dealkylation. These metabolic pathways are fully characterized for compound 1. In HLM, the dehalogenated metabolite accounts for about 87% of the full 1 metabolism, while the N-dealkylated metabolite accounts for 12%. Inhibition studies performed using different CYP-inhibitors indicate that the 3A family is the isoenzyme family most involved in pyrazolo[3,4-d]pyrimidine metabolism. This observation is confirmed by studies performed by using CYP3A selective substrates. Furthermore kinetic analysis performed in RLM, HLM and cDNA CYP3A4 shows that the affinity of CYPs towards compound 1 is similar in all the tested preparations (Km = 32.7, 21.8, and 48.7 µM, respectively).
Cardiac tamponade and central venous catheters. (1975)

An analysis of the reports on 16 patients who developed cardiac tamponade, complicating the use of central venous catheters, showed that 14 died. The two survivors were treated by removal of the catheter and needle aspiration of the pericardial fluid. Some patients complained of warning symptoms such as nausea, pain, and dyspnoea, and the combination of tachycardia, hypotension, and raised venous pressure was common. We suggest that awareness of the hazard, radiographic visualization of the catheter tip, and expeditious treatment would reduce the mortality.
A Deterministic Annealing Approach to the Multiple Traveling Salesmen and Related Problems (2016)

This paper presents a novel and efficient heuristic framework for approximating the solutions to the multiple traveling salesmen problem (m-TSP) and other variants on the TSP. The approach adopted in this paper is an extension of the Maximum-Entropy-Principle (MEP) and the Deterministic Annealing (DA) algorithm. The framework is presented as a general tool that can be suitably adapted to a number of variants on the basic TSP. Additionally, unlike most other heuristics for the TSP, the framework presented in this paper is independent of the edges defined between any two pairs of nodes. This makes the algorithm particularly suited for variants such as the close-enough traveling salesman problem (CETSP) which are challenging due to added computational complexity. The examples presented in this paper illustrate the effectiveness of this new framework for use in TSP and many variants thereof.
Formation of carbon monoxide from the photodegradation of terrestrial dissolved organic carbon in natural waters (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation of carbon monoxide from the photodegradation of terrestrial dissolved organic carbon in natural watersRichard L. Valentine and Richard G. ZeppCite this: Environ. Sci. Technol. 1993, 27, 2, 409–412Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/es00039a023https://doi.org/10.1021/es00039a023research-articleACS PublicationsRequest reuse permissionsArticle Views712Altmetric-Citations149LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Poly(methyl α‐trifluoromethylacrylate) as a positive electron beam resist (1983)

Abstract A mechanistic hypothesis is presented which explains the radiation chemistry of poly(methyl α‐haloacrylate)s. In order to test the hypothesis poly(methyl α‐trifluoromethylacrylate) PMTFMA was synthesized together with copolymers of methyl methacrylate (MMA), and the α‐trifluoromethyl analog. The mechanistic hypothesis predicts that PMTFMA should have a higher G scission than PMMA and that it should have no crosslinking propensity. This prediction was verified by experiment. Imaging of PMTFMA as a positive e ‐beam resist is also presented. The new material is a more sensitive resist than PMMA.
Using an Autonomous Underwater Vehicle to Track the Thermocline Based on Peak-Gradient Detection (2012)

The thermocline plays a key role in underwater acoustics and marine ecology. In oceanographic surveys, it is often desirable to detect the thermocline and track its spatio–temporal variation. Mobility of an autonomous underwater vehicle (AUV) makes it an efficient platform for thermocline tracking. In this paper, we present an autonomous algorithm for detecting and tracking the thermocline by an AUV. The key is detection and close tracking of the maximum vertical gradient of temperature. On August 31 and September 1, 2010, the Tethys AUV ran the algorithm to closely track the thermocline across a sharp temperature front in Monterey Bay, CA.
Development of Al-Fe P/M alloy by atomization-rolling process. (1988)

Gas atomization is widely used for rapid solidification of aluminum alloys. However, ultra-rapid solidification process is required instead of gas atomization in order to modify the properties of P/M alloys, especially of the dispersion-strengthened Al-Fe alloys. To meet this requirement, atomization-rolling process, which was the combined process of gas atomization and single roller, has been being developed by the authors. In the present work, various Al-Fe alloys were rapidly solidified by means of atomization-rolling process, and consolidated by hot extrusion. Microstructure and tensile properties were evaluated in comparison with the alloys by gas atomization. Results obtained were (1) cooling rate of atomization-rolling process was 105-107°C/sec which was higher than gas atomization, (2) extruded alloys had higher strength at room and elevated temperature than the alloys by gas atomization, which was due to the finer dispersion of the intermetallic compounds by atomization-rolling process, and (3) Al-8%Fe-2%V-2%Mol%Zr alloy by atomization-rolling process had very high strength at elevated temperature. These results indicated that the atomization-rolling process was promising as the ultra-rapid solidification process.