gebhart/patrepeval huggingface dataset:
Comprehensive textbook of psychiatry/VI (1995)

Volume 1: neural sciences neuropsychiatry and behavioural neurology contributions of psychological sciences contributions of the sociocultural sciences quantitative and experimental methods in psychiatry theories of personality and psychopathology - psychoanalysis diagnosis and psychiatry - examination of the psychiatric patient clinical manifestations of psychiatric disorders classification of mental disorders delirium, dementia and amnesia and other cognitive disorders and mental disorders due to a general medical condition substance-related disorders schizophrenia other psychotic disorders mood disorders anxiety disorders somatoform disorders fractious disorders dissociative disorders normal human sexuaity, and sexual and gender identity disorders. Volume 2: eating disorders sleep disorders impulse-control disorders not elsewhere classified and adjustment disorders personality disorders psychologic factors affecting medical condition (psychosomatic disorders) relational problems additional problems that may be a focus of clinical attention psychiatry and other specialties psychiatric emergencies psychotherapies biological therapies child psychiatry psychiatric examination of the infant, child and adolescent mental retardation learning disorders, motor skills disorders, and communication disorders pervasive developmental disorders attention-deficit disorders disruptive behaviour disorders feeding and eating disorders of infancy and early childhood TIC disorders elimination disorders other disorders of infancy, childhood and adolescence mood disorders and suicide schizophrenia with childhood onset child psychiatry - psychiatric treatment child psychiatry - special areas of interest adulthood geriatric psychiatry hospital and community psychiatry psychiatric education forensic psychiatry psychiatry - past and future epilogue.
Risk Factors Associated With Failure to Reach Minimal Clinically Important Difference After Correction Surgery in Patients With Degenerative Lumbar Scoliosis (2020)

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Speed dependent rotational angular momentum polarization of the O2 (aΔg1) fragment following ozone photolysis in the wavelength range 248–265nm (2007)

The translational anisotropy and rotational angular momentum polarization of a selection of rotational states of the O2 (a 1Deltag; v=0) photofragment formed from ozone photolysis at 248, 260, and 265 nm have been determined using the technique of resonance enhanced multiphoton ionization in combination with time of flight mass spectrometry. At 248 nm, the dissociation is well described as impulsive in nature with all rotational states exhibiting similarly large, near-limiting values for the bipolar moments describing their angular momentum alignment and orientation. At 265 nm, however, the angular momentum polarization parameters determined for consecutive odd and even rotational states exhibit clear differences. Studies at the intermediate wavelength of 260 nm strongly suggest that such a difference in the angular momentum polarization is speed dependent and this proposal is consistent with the angular momentum polarization parameters extracted and reported previously for longer photolysis wavelengths [G. Hancock et al., Phys. Chem. Chem. Phys. 5, 5386 (2003); S. J. Horrocks et al., J. Chem. Phys. 126, 044308 (2007)]. The alternation of angular momentum polarization for successive odd and even J states may be a consequence of the different mechanisms leading to the formation of the two O2 (a 1Deltag) Lambda doublets. Specifically, the involvement of out of plane parent rotational motion is proposed as the origin for the observed depolarization for the Delta- relative to the Delta+ state.
Power system stabilizer (PSS) parameter design based on probabilistic eigenvalue analysis (2001)

2000-2001 > Academic research: refereed > Publication in refereed journal
EFICÁCIA DO FOSFATO DE LEVAMISOL EM NEMATÓDEOS GASTRINTESTINAIS DE CAPRINOS E OVINOS (2012)

O parasitismo gastrintestinal é considerado o principal entrave na produção de pequenos ruminantes e a ocorrência de parasitos resistentes aos anti-helmínticos tem dificultado seu controle. O objetivo deste trabalho foi avaliar a sensibilidade de nematóides gastrintestinais ao levamisol, em rebanho ovino e caprino criados simultaneamente. Foram utilizados 28 caprinos da raça Bôer e 28 ovinos da raça Texel, naturalmente infectados. Ambas as espécies foram divididas em quatro grupos de sete animais: T1) tratados com 9 mg/kg de fosfato de LEV; T2) 6,75 mg/kg; T3) 4,5 mg/kg e T4) grupo controle, sem tratamento. Os animais foram avaliados durante 21 dias para a contagem de ovos por grama de fezes - OPG, coloração da mucosa ocular com o método FAMACHA, hematócrito e peso corporal. Nos ovinos, T1 e T2 foram considerados altamente eficazes (&gt;95%) e o T3 obteve 86%, que é a dose terapêutica recomendada para ovinos. O LEV não tem indicação oficial para ser utilizado em caprinos e apresentou redução da OPG de 30, 11 e 4%, 14 dias após tratamento, comprovando sua ineficácia. As correlações entre os parâmetros avaliados nos ovinos, foram significativas (P&lt;0,01), exceto FAMACHA e peso corporal. No caso dos caprinos, a correlação FAMACHA e hematócrito também não foi significativa. O principal parasito identificado nas coproculturas das duas espécies, realizadas antes e após os tratamentos foi Haemonchus contortus (&gt;84%). Conclui-se que o LEV foi eficaz para ovinos, sendo dose-dependente. O LEV não pode ser considerado como um composto eficaz no controle de parasitos gastrintestinais em caprinos, possivelmente decorrente de alterações na cinética do produto por esta espécie animal quando comparado com ovinos, devendo ser desencorajado o seu uso.
Antioxidant enzyme activities in subcellular fractions of larvae of the black swallowtail butterfly, Papilio polyxenes (1990)

Abstract The black swallowtail butterfly, Papilio polyxenes , larvae are specialized feeders of pro‐oxidant rich plants of Apiaceae and Rutaceae. An important defense against toxic forms of oxygen species generated by ingestion of the pro‐oxidants, are the antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), GSH‐dependent glutathione peroxidases (selenium‐dependent glutathione peroxidase [GPOX] and peroxidase activity of selenium‐independent glutathione‐ S ‐transferase [GT px ]), and glutathione reductase (GR). The subcellular distribution of these enzymes in black swallowtail larvae was investigated and was found to resemble the patterns described for larvae of two other lepidopteran species: the southern armyworm, Spodoptera eridania , and the cabbage looper, Trichoplusia ni . The confinement of SOD in the cytosol and mitochondria was typically eukaryotic, but the relative proportion (1:1) was markedly different from the mammalian pattern (4:1; cytosol:mitochondria). The most obvious difference between the black swallowtail and other lepidoptera as a group, and mammalian species, is in very wide intracellular distributions of CAT, GTpx, and GR in insect species. Insects possess very low levels of a GPOX‐like activity which reduces both H 2 O 2 and organic peroxides. Consequently, insects have elaborate activities with a wide subcellular distribution of both CAT which decomposes H 2 O 2 , and GTpx which decomposes organic peroxides. The reduction of peroxides is dependent on GSH, which in this process is oxidized to GSSG. GR which reduces GSSG to GSH is also of wide subcellular distribution, analogous to the distribution pattern of GTpx.
Coexistence Between Wi-Fi and LTE on Unlicensed Spectrum: A Human-Centric Approach (2017)

In recent years, there has been great interest from the cellular service providers to use the unlicensed spectrum for their service offerings. On the other hand, existing unlicensed users in these bands (e.g., Wi-Fi in the 5-GHz band) have serious concern that such coexistence will jeopardize their service quality. Although there are some proposals on how to achieve coexistence, they are driven by the service providers and as such there remain many issues and skepticism. In this paper, we take a novel human-centric approach to understand coexistence between Wi-Fi and LTE by focusing on human satisfaction. Through mathematical modeling, problem formulation, and extensive simulations studies, we show that in terms of maximizing total human satisfaction function, there does not appear to be any advantage with the coexistence of unlicensed spectrum for Wi-Fi and LTE under static partitioning of unlicensed spectrum. This finding serves as a powerful counter argument to some LTE service providers' proposal to share the unlicensed spectrum with Wi-Fi through static partitioning. On the other hand, we find that there is a significant improvement in human satisfaction in coexistence between Wi-Fi and LTE under adaptive spectrum partitioning. Since adaptive spectrum partitioning may require a user to change its service provider whenever there is a change among the users, we propose a practical (semi-adaptive) algorithm for implementation without affecting existing users' service providers. Through performance evaluation, we show that the proposed semi-adaptive algorithm is highly competitive.
Simplified Approach for 3-D Nonlinear Induction Heating Problems (2009)

The paper presents a two-stage approach to solve a class of nonlinear 3-D eddy current problems with high saturation, typical of induction heating processes. The proposed method separates the problem of heavy nonlinearity from the complexity of the geometry, by resorting to a 1-D fast nonlinear solver which is coupled with a linear 3-D solver. Under certain hypotheses on the geometry, the approach is shown to be effective and accurate. Comparison with a commercial 3-D nonlinear code are provided.
Speeding up Dense Disparity Estimation of Stereo Couples Thanks to Horizontal Intensity Gradient (2009)

This paper presents an original development of disparity estimation from stereo couples primarily based on the similarity of image gradient between both images. Each pixel of the left image is associated to right image pixels with same gradient and similar intensity, directly leading to a set of disparities equal to the horizontal displacement in the specific case of epipolar images. Disparity values are restricted to an a priori acceptable range generally known by the application. The final disparity value assigned to a left image pixel is obtained from the histogram peak of candidate disparity values associated to pixels in the vicinity of the left pixel. A dense disparity map is produced. The conception and development have followed a very fast processing objective, resulting in about 0.75 Mpixel of disparity values per second on a 2.33 GHz Intel Core 2 Duo CPU. The approach has been successfully applied to highlight buildings or verify their presence in several types of satellite and aerial images.
Finding the place of histone deacetylase inhibitors in prostate cancer therapy (2009)

Histone deacetylase inhibitors (HDACIs) are showing promise as therapeutic agents for hematological malignancies and solid tumors. In the case of prostate cancer, HDACIs are effective at inhibiting proliferation and inducing apoptosis in a range of in vitro and in vivo experimental models. Recent studies have revealed that the actions of HDACIs in prostate cancer cells extend beyond regulation of histone acetylation and affect proteins involved in maintaining cellular homeostasis and tumor progression, including the androgen receptor, p21(WAF1) and VEGF. The broad spectrum of HDACI targets has allowed rational design of combinations with other therapeutic agents to target multiple pathways involved in prostate cancer progression, including angiogenesis and androgen signaling. In particular, synergistic inhibition of prostate cancer cell growth has been demonstrated using HDACIs in combination with radio- and chemo-therapy, Apo2L/TRAIL, angiogenesis inhibitors, heat-shock protein 90 inhibitors and androgen receptor antagonists. This review examines the current understanding of the actions of HDACIs in prostate cancer cells, both in a laboratory and a clinical context and discusses the potential utility of combination strategies for the treatment of prostate cancer.
A Functional Dynamics Approach to Modelling of Glycolysis (2004)

The access to ever increasing computer power as well as the availability of huge amounts of raw data from high-throughput experimental techniques in genomics and proteomics have renewed interest in the modelling of biosystems. The dream is in silicio biology where computer models have become so sophisticated that answers to biological relevant questions can equally well but with much less effort be given by the computer as by the cell.
Fully Quantum Mechanical Description of Proteins in Solution. Combining Linear Scaling Quantum Mechanical Methodologies with the Poisson−Boltzmann Equation (1999)

In this paper we report a method for solving the Schrödinger equation for large molecules in solution which involved merging a linear scaling divide and conquer (D&C) semiempirical algorithm with the Poisson−Boltzmann (PB) equation. We then assess the performance of our self-consistent reaction field (SCRF) approach by comparing our D&C-PB calculations for a set of 29 neutral and 36 charged molecules with those obtained by ab initio GVB and DFT (B3LYP) methods, Cramer and Truhlar's semiempirical generalized-Born SM5 model, and with the experimental solvation free energies. Furthermore, we show that our SCRF method can be used to perform fully quantum mechanical calculations of proteins in solution in a reasonable amount of time on a modern workstation. We believe that all electrostatic interactions in biological systems require a quantum mechanical description in order to obtain an accurate representation. Thus, our new SCRF method should have an impact on the computational study of physical and chemical phenomena occurring in proteins and nucleic acids, which are, in general, strongly influenced by electrostatic interactions. Moreover, this may lead to novel insights into classic problems like protein folding or drug design.
Synthesis and Biological Evaluation of 5-Fluoro-2'-deoxyuridine Phosphoramidate Analogs (1995)

A series of alkylating phosphoramidate analogs of 5-fluoro-2'-deoxyuridine has been prepared and their growth inhibitory activity evaluated against murine L1210 leukemia and B16 melanoma cells in vitro. These compounds were designed to undergo intracellular release of the phosphoramidate anions, which it was hoped would function as irreversible inhibitors of thymidylate synthase. The expectation was that binding of the nucleoside moiety would be followed by alkylation of the enzyme via the phosphoramidate. The chloride, bromide, iodide, and tosylate analogs were highly potent inhibitors of L1210 cell proliferation, with increased inhibition observed at both higher drug concentrations and longer exposure times. Addition of thymidine completely reversed the inhibition for all compounds, suggesting that these compounds are acting via inhibition of thymidylate synthase. Although the nonalkylating morpholine analog 1f was ca. 50-fold less potent than the methyl(chloroethyl)amino compound, the piperidine analog 1g was only 2-fold less potent, confirming that nitrogen basicity may be as important as the presence of an alkylating group. Addition of thymidine reversed the growth inhibition of the morpholine and piperidine analogs, suggesting that these compounds may also undergo intracellular conversion to 5-fluoro-2'-deoxyuridine 5'monophosphate. The thymidine and deoxyuridine derivatives 2 and 3 showed minimal growth inhibition in the L1210 assay. The alkylating analogs showed modest cytotoxicity against B16 melanoma cells, and the potency of the analogs was more dependent upon the alkylating moiety than on the 5-substituent.
Sigmoid Stiffener for Decompression Tube Placement in Colonic Pseudo-Obstruction (2002)

The use of a sigmoid stiffener during colonic decompression allows more proximal colonoscopy and decompression tube placement, with possible clinical benefit. We do not use this technique in the setting of left colon ischemia.
Assembly of a Nanoreactor System with Confined Magnetite Core and Shell for Enhanced Fenton‐Like Catalysis (2014)

Conventional solid catalysts for heterogeneous Fenton-like reactions in bulk solution usually suffer from aggregation and vulnerability, which greatly lower the catalytic efficiency and hamper their practical application. Herein, we demonstrate a promising yolk-shell nanostructure with both the core and the shell composed of magnetite (designated as yolk-like Fe3O4@Fe3O4/C) as a nanoreactor capable of accommodating the Fenton-like reaction into its void space. Benefiting from the mesoporous shell and perfect interior cavity of this composite, reactants can access and be abundantly confined within the microenvironment where Fe3O4 sites are dispersed on the entire cavity surfaces, thus leading to a higher catalytic efficiency compared with the conventional solid catalysts in bulk solution. The chosen model reaction of chlorophenols degradation in the presence of the as-prepared materials as well as hydrogen peroxide (H2O2) confirms this assumption. Under the optimal reaction conditions, more than 97 % 4-chlorophenol (4-CP) can be degraded in the Fe3O4@Fe3O4/C nanoreactor, whereas only 28 % can be achieved by using bare Fe3O4 particles within 60 min. Furthermore, owing to the existence of the outermost carbon layer and high-magnetization properties, the nanoreactor can be re-used for several runs. The synthesized nanoreactor displays superior catalytic activity toward the Fenton-like reaction compared with the bare solid catalysts, and thereby holds significant potential for practical application in environmental remediation.
Patients’ Perceptions of Overall Function, Pain, and Appearance After Primary Posterior Instrumentation and Fusion for Idiopathic Scoliosis (1999)

The strongest predictors of self-perceived favorable outcome among patients were female sex and white race. It is also suggested that longer fusions to L1 through L3 lead to less perceived pain than with shorter fusions.
P122 What do patients with lupus and Sjögren’s syndrome know about cardiovascular risk? (2020)

<h3>Background</h3> Cardiovascular risk (CVR) is the leading cause of mortality in patients with lupus. Understanding increased CVR in autoimmune rheumatic diseases could improve management of risk in patients. This event aimed to explore patient opinions about CVR and potential CVR treatment options. <h3>Methods</h3> We hosted a patient event promoted through social media, relevant charities, hospitals and research groups. 13 patients with lupus and/or Sjögren’s syndrome attended and were asked about CVR using a questionnaire (14 questions) and round table discussion with patients, researchers, clinicians and dietitians. <h3>Results</h3> Sixty percent of patients were aware of the increased CVR associated with autoimmune rheumatic disease and 60% stated that their doctor had spoken to them about this risk. 73% thought that it was important for them to be aware of this increased CVR. When asked about medication to reduce CVR, no patients wanted to take a statin (lipid lowering drug), however, 70% of patients would take statins if advised to do so by their doctor. Conversely, respondents were more positive about using diet or taking a dietary supplement to reduce CVR; 71% would change their diet and 57% would take a supplement either on their own accord or on advice from health professionals. Some patients had already made changes to their diet to reduce their CVR, including reducing fat and increasing fruit and vegetable consumption. All attendees were prepared to participate in a clinical study using diet modification strategies, having vascular scans to assess atherosclerosis and provide blood samples for CVR research in lupus/Sjögren’s syndrome. <h3>Conclusion</h3> This multidisciplinary event successfully gathered patient information regarding CVR. The opinions and comments provided evidence that patients support further research in cardiovascular studies and a preference to changing their diet or take a supplement, whilst avoiding medication, to reduce their CVR.
Annexin II Interactions with the Annexin II Receptor Enhance Multiple Myeloma Cell Adhesion and Growth In the Bone Marrow Microenvironment (2010)

Abstract Abstract 130 Multiple myeloma (MM) is an incurable B-cell malignancy that develops in the bone marrow. The marrow microenvironment plays a critical role in supporting homing, lodging, and growth of MM cells by activating signaling pathways in both MM and bone marrow stromal cells (BMSC). Recently, we identified that annexin II (AXII) is involved in prostate cancer cell lodgment to the bone marrow as well as mobilization of prostate cancer cells to the peripheral blood. AXII expressed on stromal cells supports prostate cancer cell lodgment via the annexin II receptor (AXIIR) on prostate cancer cells. We hypothesized that MM cells use a similar mechanism to lodge and grow in the bone marrow. We demonstrated using bio-AXII, that MM cell lines and primary MM cells from 8 MM patients express the AXIIR protein. In addition, MM cells adhered significantly better to BMSC from wild-type mice than from AXII−/− mice. Knockdown of AXIIR by siRNA in MM.1S and ANBL.6 MM cells resulted in decreased AXII binding and decreased adherence of MM cells to KM101 stromal cells and BMSC from wild-type mice. Furthermore, the adhesion of MM.1SsiCon and MM.1SsiAXIIR cells to AXII−/− BMSC was similar indicating that AXII produced by MM cells does not act in an autocrine manner on attachment. Therefore, our studies indicate the importance of the interaction of AXII on BMSC with AXIIR on MM cells in adhesion. Our studies also revealed a role for AXIIR signaling on MM cell growth. We found that soluble AXII was released by osteoclasts into their conditioned media and stimulated the growth of MM cells via ERK1/2 and AKT phosphorylation in MM cells. AXII stimulation of MM cell growth was blocked by AXII antibody or by blocking ERK1/2 and AKT phosphorylation. In contrast, endogenous AXII produced by MM.1S cells did not stimulate MM.1S cell growth suggesting that autocrine AXII/AXIIR signaling in MM.1S cells does not contribute to MM.1S cell growth. Taken together, these results suggest that AXII/AXIIR axis in the myeloma microenvironment plays an important role in MM cell adhesion and growth through production of AXII by BMSC and osteoclasts. Disclosures: No relevant conflicts of interest to declare.
Genotyping of known SNPs from ClinVar using the VCF and gVCF file formats and the number of homozygous reference sites and no-calls based on WGS data. (2015)

&lt;p&gt;Genotyping of known SNPs from ClinVar using the VCF and gVCF file formats and the number of homozygous reference sites and no-calls based on WGS data.&lt;/p&gt;
有關傅柯Governmentality的幾 (自) 問幾 (自 )答 (2011)

Governmentality是傅柯後期研究中的重要概念。Governmentality是治理機構（Governing Authorities可以是，但不一定是政府）如何將被治理者塑造成「良好公民」的手段，以及在行使這些手段時所需動員的一切機構、知識、意識形 態的整合。Governmentality作為一種權力體系時，我會稱之為治理體，而當討論側重於這治理體內的運作時，則稱治理術。