gebhart/patrepeval huggingface dataset:
Effect of Thermal History on Structural Changes in Melt‐Intercalated Poly(ε‐caprolactone)/Organoclay Nanocomposites Investigated by Dynamic Viscoelastic Relaxation Measurements (2003)

Abstract Poly( ε ‐caprolactone) (PCL) nanocomposites were prepared using two different types of organically modified nanosilicates by melt intercalation with an internal mixer. Dynamic mechanical analysis revealed possible structural changes in the nanocomposites even during the small deformation occurring during shear oscillatory measurements, as evidenced by a V‐shaped modulus change in the plot of the dynamic storage modulus as a function of stepwise increased temperature. X‐ray diffraction patterns were recorded at different simulated temperatures during the various stages of dynamic measurements. The X‐ray data indicate that the structural changes can be ascribed to a further intercalation of the PCL matrix chains into the silicate layers. This further intercalation is a consequence of the heat treatment during the dynamic mechanical measurements. Furthermore, there is a considerable vertical shift in addition to the horizontal shift in the higher temperature regime, which allows the mapping of a master curve through the application of the time‐temperature superposition principle to the dynamic storage and the loss modulus data obtained at various isothermal temperatures. The present study is also concerned with the relative molecular mobility of both PCL nanocomposites in the given experimental conditions considering the Williams‐Landel‐Ferry (WLF) equation and the Arrhenius relationship between the horizontal shift factor and the activation energy of flow. Moreover, the extent of the vertical shift as a function of temperature made it possible to determine the apparent activation energy of the further intercalation of PCL into the silicate layers. This intercalation is caused by the additional exposure to heat during the dynamic mechanical measurements after mixing, which led to a comparison of the relative diffusivity of the PCL matrix in the two nanocomposites. Dynamic shear storage moduli G′ of PCLOC25A and PCLOC30B as a function of temperature with increase increments of 20 °C from 60 to 260 °C. The G′ data were obtained from isothermal frequency sweep G′ ( ω ) data at ω = 1 rad · s −1 at the corresponding temperatures. magnified image Dynamic shear storage moduli G′ of PCLOC25A and PCLOC30B as a function of temperature with increase increments of 20 °C from 60 to 260 °C. The G′ data were obtained from isothermal frequency sweep G′ ( ω ) data at ω = 1 rad · s −1 at the corresponding temperatures.
BONE REGENERATION GUIDED BY RESORBABLE COLLAGEN MEMBRANES IN RABBITS (1993)

Artificial cross-shaped intrabony defects were created in the mandibles of 12 rabbits and the cavities covered with Type I highly cross-linked resorbable collagen membranes for 30 days. Similar cavities were prepared in three control animals and left uncovered for the same time period. Morphological and analytical data were obtained by means of light microscopy, scanning electron microscopy, and x-ray energy-dispersive spectrometry. After the experimental period, the membrane covered cavities were completely filled with regenerated bone. In the control specimens, the artificial cavities were occupied by fibrous connective tissue.
Synthetic cementum protein 1–derived peptide regulates mineralization in vitro and promotes bone regeneration in vivo (2018)

The use of recombinant proteins has revolutionized the development of biologic pharmaceuticals; however, they are not free of complications. Some have very high molecular weight, some demonstrate in vivo instability, and the high cost of producing them remains a major problem. On the other hand, it has been shown that peptides derived from active domains keep their biologic activity and can trigger events, such as osteogenesis and bone regeneration. Small peptides are advantageous because of their ease of synthesis and handling and their low immunogenic activity. The purpose of this study was to investigate the functions of a synthetic peptide, cementum protein 1-peptide1 (CEMP-1-p1), both in vitro and in vivo. Our results show that CEMP-1-p1 significantly enhanced the proliferation and differentiation of human periodontal ligament cells toward a mineralizing-like phenotype, as evidenced by increasing alkaline phosphatase (ALP)-specific activity and osterix, runt-related transcription factor (RUNX)-2, integrin binding sialoprotein, bone morphogenetic protein-2, osteocalcin, and cementum protein (CEMP)-1 expression at mRNA and protein levels. In vivo assays performed through standardized critical-size calvarial defects in rats treated with CEMP-1-p1 resulted in newly formed bone after 30 and 60 d. These data demonstrate that CEMP-1-p1 is an effective bioactive peptide for bone tissue regeneration. The application of this bioactive peptide may lead to implementing new strategies for the regeneration of bone and other mineralized tissues.-Correa, R., Arenas, J., Montoya, G., Hoz, L., López, S., Salgado, F., Arroyo, R., Salmeron, N., Romo, E., Zeichner-David, M., Arzate, H. Synthetic cementum protein 1-derived peptide regulates mineralization in vitro and promotes bone regeneration in vivo.
The transcriptional control of the perforin locus (2010)

Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) use cytotoxic granules containing perforin and granzymes to lyse infected or malignant host cells, thereby providing immunity to intracellular microbes and tumors. Perforin is essential for cytotoxic granule-mediated killing. Perforin expression is regulated transcriptionally and correlates tightly with the development of cells that can exhibit cytotoxic activity. Although a number of genes transcribed by T cells and NK cells have been studied, the cell-specificity of perforin gene expression makes it an ideal model system in which to clarify the transcriptional mechanisms that guide the development and activation of cytotoxic lymphocytes. In this review, we discuss what is known about perforin expression and its regulation, then elaborate on recent studies that utilized chromosome transfer and bacterial artificial chromosome transgenics to define a comprehensive set of cis-regulatory regions that control transcription of the human PRF1 gene in a near-physiologic context. In addition, we compare the human and murine Prf1 loci and discuss how transcription factors known to be important for driving CTL differentiation might also directly regulate the cis-acting domains that control Prf1. Our review emphasizes how studies of PRF1/Prf1 gene transcription can illuminate not only the mechanisms of cytotoxic lymphocyte differentiation but also some basic principles of transcriptional regulation.
Organ burden and pulmonary toxicity of nano-sized copper (II) oxide particles after short-term inhalation exposure (2016)

A 5-d, 6-h/day exposure equivalent to an aerosol of agglomerated CuO NPs resulted in a dose-dependent toxicity in rats, which almost completely resolved during a 3-week post-exposure period.
Fiber composite materials: A survey of fiber matrix interface mechanics (1973)

Report is described which discusses mechanism of load transfer from matrix to fiber through interface and effects of interface on composite structural integrity. Theoretical considerations are supplemented with experimental data. General trends and significant points are illustrated graphically.
Kinetics of the reaction of a secondary alkyl radical with tri-n-butylgermanium hydride and calibration of a secondary alkyl radical clock reaction (1987)

Arrhenius parameters for the reaction of a secondary alkyl radical with tri-n-butylgermanium hydride have been measured by using the cyclization of 1-methyl-5-hexenyl radical as a "clock" reaction. At 298 K the rate constant is 1.8 × 10 4 M -1 s -1, which makes the secondary alkyl radical/n-Bu 3GeH reaction about 80 times slower than the corresponding reaction with tri-n-butyltin hydride. The secondary alkyl radical clock reaction has been rather precisely calibrated by using new data and data from the literature. An attempt to carry out similar experiments with 1,1-dimethyl-5-hexenyl yielded much less precise data for the cyclization of this tertiary alkyl radical. Reliable kinetic data for hydrogen abstraction from n-Bu 3GeH by tertiary alkyl radicals could not be obtained by using either the parent bromide or appropriate N-hydroxypyridine-2-thione esters as alkyl radical sources.
Optimal Diets to Prevent Heart Disease—Reply (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mechanisms of steroid oxidation by microorganisms. XIII. C22 acid intermediates in the degradation of the cholesterol side chain (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanisms of steroid oxidation by microorganisms. XIII. C22 acid intermediates in the degradation of the cholesterol side chainCharles J. Sih, Kuang-Chao. Wang, and Hsin-Hsiung. TaiCite this: Biochemistry 1968, 7, 2, 796–807Publication Date (Print):February 1, 1968Publication History Published online1 May 2002Published inissue 1 February 1968https://pubs.acs.org/doi/10.1021/bi00842a038https://doi.org/10.1021/bi00842a038research-articleACS PublicationsRequest reuse permissionsArticle Views139Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Role of chemokines in resectable non-small cell lung cancer (NSCLC) (2019)

<b>Objectives:</b> Complex network of chemokines is a part of immune reaction targeted against tumor cells. Chemokines influence cancer growth. It is not clear whether the concentrations of chemokines at the time of NSCLC diagnosis differ from healthy controls, reflect extent of NSCLC. <b>Aim:</b> To compare chemokine concentrations (CCL2, CCL8, CXCL12) in plasma of patients with resectable NSCLC to those without cancer. To find out whether the chemokine concentrations differ according to stage of the disease. <b>Material and Methods:</b> We enrolled 69 patients undergoing surgery for proven/suspected NSCLC (37 males-mean age 66 years, 32 females-mean age 64 years). They underwent standard diagnostic and staging procedure to determine resectability, then surgery was performed. We diagnosed 42 patients with NSCLC. 27 patients in the control group had benign lung pathologies, remained as the control group. We assessed chemokine concentrations in peripheral blood by ELISA LSBio Kits. Parametric statistics was used for analysis. Stages II+IIIa were evaluated together. <b>Results:</b> <b>Conclusion:</b> Chemokine values did not differ in NSCLC total vs. control group. Patients with NSCLC stage II+IIIA had significantly higher CXCL12 concentrations than control group, even higher than stage I. The CXCL12 relates tumor growth, might be a biomarker of advanced disease.
Text feature extraction based on deep learning: a review (2017)

Selection of text feature item is a basic and important matter for text mining and information retrieval. Traditional methods of feature extraction require handcrafted features. To hand-design, an effective feature is a lengthy process, but aiming at new applications, deep learning enables to acquire new effective feature representation from training data. As a new feature extraction method, deep learning has made achievements in text mining. The major difference between deep learning and conventional methods is that deep learning automatically learns features from big data, instead of adopting handcrafted features, which mainly depends on priori knowledge of designers and is highly impossible to take the advantage of big data. Deep learning can automatically learn feature representation from big data, including millions of parameters. This thesis outlines the common methods used in text feature extraction first, and then expands frequently used deep learning methods in text feature extraction and its applications, and forecasts the application of deep learning in feature extraction.
촉매열분해를 이용한 백합나무 바이오오일의 연료 특성 (2017)

바이오오일은 고품질 화학물질로 이용이 가능하며 차세대 탄화수소 연료와 석유정제업 공급원료로 사용할 수 있기 때문에 촉망받는 신재생에너지의 하나로 상당한 관심을 받고 있다. 또한 제올라이트는 급속열분해 과정에서 크래킹 반응을 효과적으로 촉진시켜 탈산소 반응을 증가 시키고 탄화수소가 많은 안정된 바이오오일을 만든다. 그래서 본 연구에서는 백합나무 바이오오일...
In‐situ Measurement of Primary Particle Sizes during Carbon Black Production (2003)

During the production of carbon black monitoring of primary particle size plays an important role since this parameter determines product properties and is specified accordingly. For process control fast information about this size is absolutely necessary. In the work presented here it was investigated whether time‐resolved laser‐induced incandescence is suitable for on‐line measurement of primary particle sizes of carbon black during the production process. The results obtained experimentally in industrial production and test reactors were compared with values for the specific surface area from laboratory analyses of sampled material.
Primary Mouse Myoblast Purification using Magnetic Cell Separation (2017)

Primary myoblasts can be isolated from mouse muscle cell extracts and cultured in vitro. Muscle cells are usually dissociated manually by mincing with razor blades or scissors in a collagenase/dispase solution. Primary myoblasts are then gradually enriched by pre-plating on collagen-coated plates, based on the observation that mouse fibroblasts attach quickly to collagen-coated plates, and are less adherent. Here, we describe an automated muscle dissociation protocol. We also propose an alternative to pre-plating using magnetic bead separation of primary myoblasts, which improve myoblast purity by minimizing fibroblast contamination.
The Role of Regional Therapies for in-Transit Melanoma in the Era of Improved Systemic Options (2015)

The incidence of melanoma has been increasing at a rapid rate, with 4%-11% of all melanoma recurrences presenting as in-transit disease. Treatments for in-transit melanoma of the extremity are varied and include surgical excision, lesional injection, regional techniques and systemic therapies. Excision to clear margins is preferred; however, in cases of widespread disease, this may not be practical. Historically, intralesional therapies were generally not curative and were often used for palliation or as adjuncts to other therapies, but recent advances in oncolytic viruses may change this paradigm. Radiation as a regional therapy can be quite locally toxic and is typically relegated to disease control and symptom relief in patients with limited treatment options. Regional therapies such as isolated limb perfusion and isolated limb infusion are older therapies, but offer the ability to treat bulky disease for curative intent with a high response rate. These techniques have their associated toxicities and can be technically challenging. Historically, systemic therapy with chemotherapies and biochemotherapies were relatively ineffective and highly toxic. With the advent of novel immunotherapeutic and targeted small molecule agents for the treatment of metastatic melanoma, the armamentarium against in-transit disease has expanded. Given the multitude of options, many different combinations and sequences of therapies can be offered to patients with in-transit extremity melanoma in the contemporary era. Reported response and survival rates of the varied treatments may offer valuable information regarding treatment decisions for patients with in-transit melanoma and provide rationale for these decisions.
The analysis and identification of homologizer/moderator variables when the moderator is continuous: An illustration with anthropometric data (1992)

Human biological data often contain homologizers, that is, variables which moderate the strength rather than the form of the relationship between two other variables. Current methods for the identification and analysis of continuous homologizer variables [Z] (variables which moderate the strength rather than the form of a relationship between other variables [X,Y]) recommend dividing the sample into subgroups on the basis of the homologizer variable (Z) and testing whether correlations (X,Y) are significantly different among subgroups. We propose an alternative strategy which avoids the use of subgroups and which offers greater power to detect homologizer effects. In addition, it allows the identification of homologizer effects in data sets where multiplicative as well as additive terms are included in the model. The proposed strategy is validated through Monte Carlo simulations and an example of its application to a set of anthropometric data is given. © 1992 Wiley-Liss, Inc.
Domain Shuffling Has Been the Main Mechanism Forming New Hominoid Killer Cell Ig-Like Receptors (2004)

The killer cell Ig-like receptor (KIR) gene family encodes MHC class I-specific receptors, which regulate NK cell responses and are also expressed on subpopulations of T cells. KIR haplotypes vary in gene content, which, in combination with allelic polymorphism, extensively diversifies the KIR genotype both within and between human populations. Species comparison indicates that formation of new KIR genes and loss of old ones are frequent events, so that few genes are conserved even between closely related species. In this regard, the hominoids define a time frame that is particularly informative for understanding the processes of KIR evolution and its potential impact on killer cell biology. KIR cDNA were characterized from PBMC of three gorillas, and genomic DNA were characterized for six additional individuals. Eleven gorilla KIR genes were defined. With attainment of these data, a set of 75 KIR sequences representing five hominoid species was assembled, which also included rhesus monkey, cattle, and rodent KIR. Searching this data set for recombination events, and phylogenetic analysis using Bayesian methods, demonstrated that new KIR were usually the result of recombination between loci in which complete protein domains were shuffled. Further phylogenetic analysis of the KIR sequences after removal of confounding recombined segments showed that only two KIR genes, KIR2DL4 and KIR2DL5, have been preserved throughout hominoid evolution, and one of them, KIR2DL4, is also common to rhesus monkey and hominoids. Other KIR genes represent recombinant forms present in a minority of species, often only one, as exemplified by 8 of the 11 gorilla KIR genes.
Plasma-enhanced CVD of titanium silicide (1984)

The continuing trend toward smaller geometries and thinner junctions mandates that interconnect and gate materials have the lowest resistivity possible. Titanium silicide has the lowest resistivity of the refractory metal silicides and is, therefore, the prime candidate for advanced VLSI processing. This paper describes the CVD of titanium silicide in the ASM PECVD system. Reactor characteristics, deposition uniformities, and properties of the as-deposited and annealed films are discussed. Film resistivity, after a 10 min anneal at 650 °C, is typically 15 to 20 μΩ cm. This result is obtained at a lower temperature (by about 100 °C) and lower resistivity (by about 25%) than is usually attainable with sputter-deposited TiSix. Analysis using Rutherford backscattering spectrometry and Auger electron spectroscopy also indicates considerably better purity with these PECVD films. The step coverage of CVD TiSix is essentially conformal.
Total synthesis of (-)-mirabazole C (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (-)-mirabazole CMichael A. Walker and Clayton H. HeathcockCite this: J. Org. Chem. 1992, 57, 21, 5566–5568Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/jo00047a005https://doi.org/10.1021/jo00047a005research-articleACS PublicationsRequest reuse permissionsArticle Views640Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
From Cyclohexane to 2-Hydroxy-3-oxanone:  A Conformation Study (1998)

Density functional calculations are reported on all stable chair and twist-boat conformations of cyclohexane, cyclohexanol, oxane, cyclohexanone, 3-oxanone, 2-oxanol, 2-hydroxycyclohexanone, and 2-hydroxy-3-oxanone. With just one exception, the chair conformation is predicted to lie lower in energy than the twist-boat conformations. Either individually replacing a hydroxyl for hydrogen, introducing an oxygen into the ring, or incorporating a carbonyl group into cyclohexane reduces the energy difference between chair and twist-boat. In cyclohexanol the equatorial chair lies lower in energy than the axial chair. The axial chair anomers of 2-oxanol, 2-hydroxycyclohexanone, and 2-hydroxy-3-oxanone lie lower in energy than the equatorial chair anomers. In 2-hydroxy-3-oxanone the equatorial chair lies higher in energy than one of the twist-boat conformations. Stereoselective reduction of 2-hydroxy-3-oxanones is shown to result from sterically controlled attack.