gebhart/patrepeval huggingface dataset:
CORDIC-based computation of ArcCos and ArcSin (2002)

CORDIC-based algorithms to compute cos/sup -1/(t), sin/sup -1/(t) and /spl radic/(1-t/sup 2/) are proposed. The implementation requires a standard CORDIC module plus a module to compute the direction of rotation, this being the same hardware required for the extended CORDIC vectoring, recently proposed by the authors. Although these functions can be obtained as a special case of this extended vectoring, the specific algorithm we propose here presents two significant improvements: (1) it achieves an angle granularity of 2/sup -n/ using the same datapath width as the standard CORDIC algorithm (about n bits, instead of about 2n which would be required using the extended veetoring), and (2) no repetitions of iterations are needed. The proposed algorithm is compatible with the extended vectoring and, in contrast with previous implementations, the number of iterations and the delay of each iteration are the same as for the conventional CORDIC algorithm.
LAND AND WATER USE CHARACTERISTICS AND HUMAN HEALTH INPUT PARAMETERS FOR USE IN ENVIRONMENTAL DOSIMETRY AND RISK ASSESSMENTS AT THE SAVANNAH RIVER SITE (2010)

Operations at the Savannah River Site (SRS) result in releases of small amounts of radioactive materials to the atmosphere and to the Savannah River. For regulatory compliance purposes, potential offsite radiological doses are estimated annually using computer models that follow U.S. Nuclear Regulatory Commission (NRC) Regulatory Guides. Within the regulatory guides, default values are provided for many of the dose model parameters but the use of site-specific values by the applicant is encouraged. A detailed survey of land and water use parameters was conducted in 1991 and is being updated here. These parameters include local characteristics of meat, milk and vegetable production; river recreational activities; and meat, milk and vegetable consumption rates as well as other human usage parameters required in the SRS dosimetry models. In addition, the preferred elemental bioaccumulation factors and transfer factors to be used in human health exposure calculations at SRS are documented. Based on comparisons to the 2009 SRS environmental compliance doses, the following effects are expected in future SRS compliance dose calculations: (1) Aquatic all-pathway maximally exposed individual doses may go up about 10 percent due to changes in the aquatic bioaccumulation factors; (2) Aquatic all-pathway collective doses may go up about 5 percent due to changes in the aquatic bioaccumulation factors that offset the reduction in average individual water consumption rates; (3) Irrigation pathway doses to the maximally exposed individual may go up about 40 percent due to increases in the element-specific transfer factors; (4) Irrigation pathway collective doses may go down about 50 percent due to changes in food productivity and production within the 50-mile radius of SRS; (5) Air pathway doses to the maximally exposed individual may go down about 10 percent due to the changes in food productivity in the SRS area and to the changes in element-specific transfer factors; and (6) Air pathway collective doses may go down about 30 percent mainly due to the decrease in the inhalation rate assumed for the average individual.
Inhaled Lidocaine for the Treatment of Asthma: Lack of Efficacy in Two Double-Blind, Randomized, Placebo-Controlled Clinical Studies (2010)

These results indicate that lidocaine solution for inhalation is not a useful treatment for asthma; it did not improve pulmonary function and did not have a corticosteroid-sparing effect.
Xeloda<sup>®</sup> in the Treatment of Metastatic Breast Cancer (1999)

There are few treatment options available for patients with metastatic breast cancer who have failed anthracycline- and paclitaxel-based chemotherapy. Xeloda (capecitabine) is a novel selectively tumoractivated fluoropyrimidine carbamate producing clinically active levels of 5-fluorouracil (5-FU) at the tumor site. Xeloda is active in breast cancer and is administered orally. It is the only registered treatment for patients in whom anthracycline and taxoid treatment has failed. In a phase II trial of 163 paclitaxel-refractory patients with metastatic breast cancer, the overall response rate with Xeloda was 20%, with three complete responses, and the median survival was 12.8 months. A total of 20% of patients experienced a Clinical Benefit Response (a composite assessment of clinical benefit). Furthermore, Xeloda was well tolerated; the most common treatment-related adverse events were hand-foot syndrome, diarrhea, nausea, vomiting, and fatigue. Two additional studies of Xeloda in patients with metastatic breast cancer have also been completed. In the first study, patients with anthracycline-resistant metastatic breast cancer received either Xeloda or paclitaxel; the response rates were 36 and 26%, respectively. In the second study, women aged >/=55 years received first-line treatment with either Xeloda or cyclophosphamide/methotrexate/5-FU. The response rates were 25 and 16%, respectively. These studies show that Xeloda is an active agent in the treatment of metastatic breast cancer with the additional advantage of oral administration.
Sense-City innovation lab supporting recent advances on Monitoring of urban operations (2019)

International audience
Mode-Group-Selective Photonic Lantern Using Graded-Index Multimode Fibers (2015)

We fabricate mode-group-selective photonic lanterns using multimode graded-index fibers. The use of the multimode graded-index fibers in the taper can significantly relax the adiabaticity requirement in comparison with using single-mode fibers.
Experimental research on the effect of thromboxane synthase inhibitor ligustrazine on rat pancreas preservation (1996)

In this study the rat pancreas transplant model was used to determine the effect of ligustrazine in WMO-l solution on pancreas preservation.The result showed that the exact preservation time of WMO-1 sohltion for pancreas was 12h,and when pancreas was preserved for 18h,the survival rate was 1/3.Addition of ligustrazine to WMO-1 solution could prolong the preservation time to 18h,and when pancreas was preserved for 24h,the survival rate is 1/3.These findings proved that ligustrazine can improve pancreas preservation.

Key words: 
Ligustrazine; Rat; Pancreas preservation
Auditory perspective — Loud speakers and microphones (1934)

In ordinary radio broadcast of symphony music, the effort is to create the effect of taking the listener to the scene of the program, whereas in reproducing such music in a large hall before a large gathering the effect required is that of transporting the distant orchestra to the listeners. Lacking the visual diversion of watching the orchestra play, such an audience centers its interest more acutely in the music itself, thus requiring a high degree of perfection in the reproducing apparatus both as to quality and as to the illusion of localization of the various instruments. Principles of design of the loud speakers and microphones used in the Philadelphia-Washington experiment are treated at length in this, the third paper of this symposium.
Narrow- versus wide-azimuth land 3D seismic surveys (2002)

It appears that there are two very distinct schools of thought with respect to the patch configuration for land 3D seismic surveys; often the like or dislike of one over another is based on which part of the business one is involved in rather than any scientific reason. Oil and gas companies (after all the clients) may prefer a wide recording patch to maximize the truly 3D coverage while acquisition contractors (if given a choice) may opt for a narrow recording patch for operational reasons. There are more reasons than these to consider either recording patch and the benefits of both need to be considered when designing a 3D survey.
THE SURFACE TENSION OF MERCURY-THALLIUM AND MERCURY-INDIUM AMALGAMS (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE SURFACE TENSION OF MERCURY-THALLIUM AND MERCURY-INDIUM AMALGAMSD. A. Olsen and D. C. JohnsonCite this: J. Phys. Chem. 1963, 67, 12, 2529–2531Publication Date (Print):December 1, 1963Publication History Published online1 May 2002Published inissue 1 December 1963https://pubs.acs.org/doi/10.1021/j100806a006https://doi.org/10.1021/j100806a006research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Generation of Regulatory T Cells through Intravenous Delivery of Autologous Apoptotic Cells. (2004)

Abstract Extracorporeal photopheresis (ECP) is approved for the palliative treatment of skin manifestations associated with cutaneous T cell lymphoma. As reported in the literature, ECP has shown promise as a treatment for such immune-mediated inflammatory disorders as graft versus host disease, transplantation rejection, and autoimmune diseases. ECP involves the reinfusion of autologous, apoptotic peripheral blood leukocytes treated ex vivo with 8-methoxypsoralen (8-MOP) and UVA light. The biological mechanism of action of ECP, however, remains unresolved. We have evidence to suggest that delivery of ECP-treated apoptotic cells modulates immune responses, possibly through generation of regulatory T cells. When co-incubated with ECP-treated cells, activated dendritic cells produce reduced levels of proinflammatory cytokines, such as IL-12, while TGFβ levels were modestly increased. Activation of CD4+ T cells in the presence of allogeneic dendritic cells and ECP-treated cells promotes generation of a population of T cells that can suppress proliferation of, and IFNγ production by, naïve syngeneic T cells. To confirm these findings in vivo, we employed a murine contact hypersensitivity model. ECP-treated or control spleen and lymph node cells from mice sensitized with the hapten dinitrofluorobenzene (DNFB) were injected intravenously into naïve recipients. Compared to controls, mice that received ECP-treated cells demonstrated significantly less ear swelling following sensitization and challenge with DNFB. Suppression of ear swelling was specific for DNFB and cell-mediated, as demonstrated by the ability to transfer DNFB tolerance to naïve mice, which could appropriately respond to the unrelated hapten oxazalone. Transfer of this tolerance was abrogated by depletion of either CD4+ or CD25+ T cell populations. Collectively, these results suggest that delivery of ECP-treated cells promotes the generation of regulatory T cells that are capable of modulating immune responses. Therakos sponsored Phase II trials for the prevention and treatment of GvHD are concluding and an international blinded pivotal phase III study is planned for 2005.
Separation of mouse crushed muscle extract into distinct mitogenic activities by heparin affinity chromatography (1994)

Extracts from gently crushed adult mouse skeletal muscles (CMEs) contain potent myoblast mitogens, and may be used as a model system to investigate myotrophic factors released by adult muscles following injury. CME was separated into four peaks of mitogenic activity by heparin affinity chromatography. The fraction of CME that did not bind to heparin contained transferrin (Tf). Three peaks of mitogenic activity were eluted from the heparin-agarose columns at NaCl concentrations of 0.4 M, 0.9 M, and 2.0 M. A 46 kDa protein that shared antigenicity with the BB isoform of platelet-derived growth factor (PDGF-BB) was present in the 0.4 M NaCl eluant. Mitogenic activity in the 2.0 M NaCl peak eluted identically to purified basic fibroblast growth factor (bFGF), did not act additively to saturating amounts of purified bFGF, and was neutralized by anti-bFGF antibodies. The 0.9 M NaCl eluant acted additively to the combination of three known growth factors for myoblasts, bFGF, insulin-like growth factor 1, and epidermal growth factor, to stimulate C2 myoblast proliferation, suggesting this fraction contains a mitogenic activity which does not utilize (and hence compete for) receptors for the known mitogens for myoblasts. Additionally, the 0.9 M NaCl eluant did not stimulate proliferation of fibroblast-like cells derived from muscle tissue. The unbound, 0.4 M NaCl, 0.9 M NaCl, and 2.0 M NaCl eluants from the heparin-agarose column acted additively to one another to stimulate myoblast proliferation. Our data suggest that Tf, PDGF-BB-like molecules, bFGF-like activity, and an uncharacterized heparin-binding myoblast mitogen could be released after muscle injury and act to stimulate satellite cell proliferation.
Optical Fiber Phase Discriminator (1978)

Phase discriminators are devices widely used at rf and microwave frequencies to convert phase, or frequency, changes to amplitude changes. They find widespread use in generating audio feedback signals for frequency stabilization of oscillators and in angle demodulation applications. This paper demonstrates that similar devices, with similar functions, can be constructed in the visible region using optical fibers as delay-line elements. The operating principles of an optical-fiber delay-line phase discriminator are discussed. The sensitivity is shown to be proportional to the fiber propagation-delay time. A device working at 0.6328 microm is described and compared with predictions.
Review of the potential of a wireless MEMS microsystem for biomedical applications (2005)

Purpose Telemetry capsules have existed since the 1950s and were used to measure temperature, pH or pressure inside the gastrointestinal (GI) tract. It was hoped that these capsules would replace invasive techniques in the diagnosis of function disorders in the GI tract. However, problems such as signal loss and uncertainty of the pills position limited their use in a clinical setting. In this paper, a review of the capabilities of microelectromechanical systems (MEMS) for the fabrication of a wireless pressure sensor microsystem is presented. Design/methodology/approach The circuit requirements and methods of data transfer are examined. The available fabrication methods for MEMS sensors are also discussed and examples of wireless sensors are given. Finally, the drawbacks of using this technology are examined. Findings MEMS for use in wireless monitoring of pressure in the GI tract have been investigated. It has been shown that capacitive pressure sensors are particularly suitable for this purpose. Sensors fabricated for wireless continuous monitoring of pressure have been reviewed. Great progress, especially using surface micromachining, has been made in recent years. However, despite these advances, some challenges remain. Originality/value Provides a review of the capabilities of MEMS.
Towards effective and efficient search-based deterministic replay (2013)

Deterministic replay tools are a useful asset when it comes to pinpoint hard-to-reproduce bugs. However, no sweet spot has yet been found with respect to the trade-off between recording overhead and bug reproducibility, especially in the context of search-based deterministic replay techniques, which rely on inference mechanisms.
Nano-Scale Abrasion Studies of Materials Used in MEMS Devices and Packages (2005)

Abrasion plays an important role in the manufacture and use of certain microstructures. In this paper, we explore the nano-scale abrasion characteristics of Al, Si, Pyrex™ glass, and glass-mica ceramic (Macor™), using a commercial scribing tool adapted to provide controlled velocity and force, and accurate positioning for abrasion utilizing two abrasion heads: a diamond facet edge and a custom alumina-grit head. While Al is easily abraded, it tends to create build-up of material along the edges. Silicon provides triangular clean groves with minimum widths ≈ 460 nm. Macor provides scalloped grooves that show some chipping and have minimum widths of ≈ 320 nm. Glass provides clean, rounded grooves, with minimum widths of ≈ 200 nm. This paper also describes how controlled abrasion can be exploited for the non-lithographic fabrication of nanochannels which are of interest in several fluidic devices.
Developments in Synthesis and Potential Electronic and Magnetic Applications of Pristine and Doped Graphynes (2021)

Doping and its consequences on the electronic features, optoelectronic features, and magnetism of graphynes (GYs) are reviewed in this work. First, synthetic strategies that consider numerous chemically and dimensionally different structures are discussed. Simultaneous or subsequent doping with heteroatoms, controlling dimensions, applying strain, and applying external electric fields can serve as effective ways to modulate the band structure of these new sp<sup>2</sup>/sp allotropes of carbon. The fundamental band gap is crucially dependent on morphology, with low dimensional GYs displaying a broader band gap than their bulk counterparts. Accurately chosen precursors and synthesis conditions ensure complete control of the morphological, electronic, and physicochemical properties of resulting GY sheets as well as the distribution of dopants deposited on GY surfaces. The uniform and quantitative inclusion of non-metallic (B, Cl, N, O, or P) and metallic (Fe, Co, or Ni) elements into graphyne derivatives were theoretically and experimentally studied, which improved their electronic and magnetic properties as row systems or in heterojunction. The effect of heteroatoms associated with metallic impurities on the magnetic properties of GYs was investigated. Finally, the flexibility of doped GYs' electronic and magnetic features recommends them for new electronic and optoelectronic applications.
Extreme Elasticity Anisotropy: Extreme Elasticity Anisotropy in Molecular Glasses (Adv. Funct. Mater. 23/2020) (2020)

In article number 2001481, Mark D. Ediger, George Fytas, and co-workers reveal the strong correlation between elastic anisotropy and molecular orientation in vapor-deposited organic glasses of rod-shaped itraconazole. Extreme elastic anisotropy, the ratio of the orthogonal Young's moduli, is observed in the vertically orientated molecules exceeding that in liquid crystals and even crystalline solids.
Insulated Molecular Wires: Synthesis of Conjugated Polyrotaxanes by Suzuki Coupling in Water (2000)

Das Poly-para-phenylen-Polyrotaxan 1 ist das erste konjugierte Polyrotaxan. Die Naphthalin-Endgruppen verhindern, dass die β-Cyclodextrinringe in Lösung vom Polyphenylenstab schlüpfen. Das MALDI-TOF-Massenspektrum von 1 zeigt eine Serie von Oligomeren, bis hin zu einem [10]Rotaxan.
Connecting secretome to hematopoietic stem cell phenotype shifts in an engineered bone marrow niche (2020)

Abstract Hematopoietic stem cells (HSCs) primarily reside in the bone marrow, where they receive external cues from their local microenvironment. The complex milieu of biophysical cues, cellular components, and cell-secreted factors regulates the process by which HSC produce the blood and immune system. We previously showed direct co-culture of primary murine hematopoietic stem and progenitor cells with a population of marrow-derived mesenchymal stromal and progenitor cells (MSPCs) in a methacrylamide-functionalized gelatin (GelMA) hydrogel improves hematopoietic progenitor maintenance. However, the mechanism by which MSPCs influenced HSC fate decisions remained unknown. Herein, we report the use of proteomic analysis to correlate HSC phenotype to a broad candidate pool of 200 soluble factors produced by combined mesenchymal and hematopoietic progeny. Partial Least Squares Regression (PLSR), along with an iterative filter method, identified TGFβ-1, MMP-3, c-RP, and TROY as positively correlated with HSC maintenance. Experimentally, we then observe exogenous stimulation of HSC monocultures in GelMA hydrogels with these combined cytokines increases the ratio of hematopoietic progenitors to committed progeny after a 7-day culture 7.52 ± 3.65 fold compared to non-stimulated monocultures. Findings suggest a cocktail of the downselected cytokines amplify hematopoietic maintenance potential of HSCs beyond that of MSPC-secreted factors alone. This work integrates empirical and computation methods to identify cytokine combinations to improve HSC maintenance within an engineered HSC niche, suggesting a route towards identifying feeder-free culture platforms for HSC expansion. Insight Hematopoietic stem cells within an artificial niche receive maintenance cues in the form of soluble factors from hematopoietic and mesenchymal progeny. Applying a proteomic regression analysis, we identify a reduced set of soluble factors correlated to maintenance of a hematopoietic phenotype during culture in a biomaterial model of the bone marrow niche. We identify a minimum factor cocktail that promotes hematopoietic maintenance potential in a gelatin-based culture, regardless of the presence of mesenchymal feeder-cells. By combining empirical and computational methods, we report an experimentally feasible number of factors from a large dataset, enabling exogenous integration of soluble factors into an engineered hematopoietic stem cell for enhance maintenance potential of a quiescent stem cell population.
fra-2 promoter can respond to serum-stimulation through AP-1 complexes. (1995)

fra-2 (fos-related antigen-2) expression is detected at a basal level even in growth-arrested chicken embryo fibroblasts (CEF), but upon serum-stimulation high levels of its transcripts are transiently observed. This induction is delayed and prolonged compared to that of c-fos. Transient expression experiments in CEF using a series of constructs of chicken fra-2 promoter region linked to the CAT reporter gene indicated previously that serum response element (SRE) is not required for full serum inducibility. In this report, we show that constructs in which the CRE-like sequence and both AP-1 binding sites are disrupted lack serum inducibility, suggesting that either of these enhancers is important in serum induction of fra-2. In growth-arrested CEF, small amounts of Fra-2/c-Jun complex bind to the AP-1 consensus sequences in fra-2 promoter, while a significant part of the enhanced AP-1 binding activity after 60-120 min of serum stimulation is attributable to c-Fos/c-Jun heterodimer. At later times Fra-2/c-Jun again becomes the main complex. Transient expression assays in F9 cells indicated that c-Fos/c-Jun heterodimers have strong stimulatory effects on fra-2 promoter activity, while Fra-2/c-Jun complex has lower transcriptional activity than that of c-Jun homodimer. These results suggest that c-Fos (induced at earlier times) and c-Jun proteins are at least partly responsible for serum-induced expression of fra-2.
Hybrid Endografts Combinations for the Treatment of Endoleak in Endovascular Abdominal Aortic Aneurysm Repair (2013)

Hybrid endografting in endovascular abdominal aortic aneurysm repair (EVAR) is defined as the process of placing a series of two or more different types of covered stents, usually to treat a complex abdominal aortic aneurysm (AAA) or a primary or secondary endoleak. We describe the treatment of a type III, a type Ib, and a type Ia endoleak in three patients respectively, using hybrid solutions, assembling components from different manufacturers. An update of the current clinical and experimental evidence on the application of anatomically compatible, hybrid endograft systems in conventional EVAR is also provided.