gebhart/patrepeval huggingface dataset:
A study on platinum(iv) species containing an estrogen receptor modulator to reverse tamoxifen resistance of breast cancer (2017)

Several dual-action Tam-Pt(iv) complexes derived from tamoxifen (Tam) and platinum(ii) drugs were designed and synthesized for targeting estrogen receptors (ERs) and DNA. These novel compounds not only exhibited potent cytotoxicity against breast cancer cells, but also reversed the tamoxifen resistance of TamR-MCF-7 cancer cells. Computational docking assays together with cellular uptake data demonstrated that the ER ligand portion of these conjugates plays a targeting role in ER-positive tumor cells and promotes the uptake of platinum via an estrogen receptor-mediated pathway. A study on the preliminary mechanism of the typical conjugate, complex 1, revealed that the Tam-Pt(iv) complex induced apoptosis via the mitochondrial-dependent apoptosis pathway mediated through the activation of caspase 3 and PARP proteins. These results suggested that the conjugation of estrogen receptor modulators with the platinum moiety could facilitate a selective enrichment of platinum in estrogen-positive tumors and possibly broaden the scope of ER ligand clinical use to resistant breast tumors.
Deep learning of spatio-temporal features with geometric-based moving point detection for motion segmentation (2014)

This paper introduces an approach to accomplish motion segmentation from a moving stereo camera based on deep learning. Previous work on moving object detection mostly use point features based on 3D geometric constraints. However, point features require good features, and are hard to detect or to be matched correctly in situations where objects have smooth textures. To alleviate this problem, learning high-level spatio-temporal features unsupervisedly from raw image data based on Reconstruction Independent Component Analysis (RICA) autoencoders is proposed. Despite the power of the new spatio-temporal features, these features cannot not learn and be used to interpret 3D geometry of dynamic scenes, which is critical for moving object detection from moving cameras. As detected moving points based on 3D geometric constraints still contain valuable information of 3D scene as well as the camera egomotion, we propose a framework that incorporates both the detected moving point results and the learned spatio-temporal features as inputs to Recursive Neural Networks (RNN) that performs motion segmentation. Both features effectively complement each other. The proposed approach is demonstrated with real-world stereo video data that contains multiple moving objects, and has achieved 26% better detection rate over the existing 3D geometric-based moving points detector.
From Sati COMMENTARY AND TRANSLATION FROM BENGALI BY RANJANA ASH (1997)

This excerpt from the last part of a short novel by Mahasweta Devi is concerned with Molina Mishra's sense of self-betrayal, faced as she is with her failure to lead a meaningful life. A middle class Bengali, a Hindu widow, an old woman of 70, he has seemed to family and friends an exemplary figure. She has lived a life of utmost simplicity, even austerity, denying herself the comforts now common among India's urban middle class while enabling her three daughters to b well educated and well married. She has spent her resources on a school for girls, and on helping abandoned and destitute women. Above all, she has remained faithful to the memory of her husband, Bejoy Mishra, a revolutionary communist of the 1930 who died a long ago as 1940 while she was still only 22. She could have remarried as there were men who loved her and her father would have had no objection. Yet she refused their offers, endured the loneliness and difficulties of life, remaining loyal to old communists who did not change their views or lifestyles amid the new politics of post­- independent India.
Methylene Analogues of Neopetrosiamide as Potential Antimetastatic Agents: Solid-Supported Syntheses Using Diamino Diacids for Pre-Stapling of Peptides with Multiple Disulfides (2021)

Neopetrosiamide, a 28-residue peptide from <i>Neopetrosia</i> sp., contains three disulfide bonds and hinders mammalian tumor cell invasion. Proper connectivity of disulfide bonds is crucial for activity. Synthetic replacement of single disulfide bridges with methylene bridges gives active analogues. Pre-stapling of one ring enhances the correct formation of the remaining disulfides by reducing isomeric possibilities and possibly initiating the correct 3D fold. Cloning and expression of neopetrosiamide in <i>E. coli</i> affords access to the natural linear peptide.
Development of new articulated manipulators with compact pneumatic cylinders (2012)

We have developed new articulated manipulators with compact pneumatic cylinders and with the high levels of structural flexibilities and safety as a result of adoption of new ideas in the structure. In developing the new articulated manipulators, we have first defined the design concepts and then described the overview of the manipulators which we have actually designed and manufactured. We have carried out experiments with the manufactured articulated manipulators for their positional controllability and stiffness characteristics, the results of which are also reported in this paper. Furthermore, this paper refers to possible applications of the developed new articulated manipulators.
Design of disk molecular pumps for hybrid molecular pumps* (1993)

In recent years, the various types of hybrid molecular pumps combining a molecular drag pump (MDP) with a turbomolecular pump (TMP) have been developed in order to raise their pumping throughput and operating pressure. Some of them have been put on the market. In this article the pumping performances of the disk MDP, whose pumping channels are cut on a rotating disk, were calculated using a new model based on the Monte Carlo method. The relationship between the pump performance to the structural parameters was studied. The above pumping performance is also compared with that of the pumps having channels on stationary disks. When a pump is constructed in a series of two stages, the pumping speed and the compression ratio of the present pump for nitrogen gas increases by 35% and 64%, respectively, as compared with the previous type. It is believed that the pump having channels on the rotating disk has both kinds of pumping actions. Hence, it possesses the advantages of both MDP and TMP.
Immunolpathology of Acute Galactosamine Hepatitis in Rats (1990)

Galactosamine hydrochloride induces liver disease in rats that morphologically resembles drug-induced hepatitis in man. In this study we analyzed the character of the inflammatory reaction following the toxic damage resulting from the administration of galactosamine hydrochloride using a broad panel of monoclonal antibodies to lymphocyte subsets and macrophages. Fat-storing cells were identified with a polyclonal anti-desmin antibody. Cellular proliferation was assessed by labeling S-phase cells with the thymidine analog bromodeoxyuridine. Injection of galactosamine hydrochloride was associated with conspicuous hepatocyte necrosis and parenchymal granulocyte influx in the first 24 hr. Thereafter, mononuclear inflammatory cells predominated, mainly T lymphocytes and macrophages, with maximal numbers at 48 hr. The majority of T lymphocytes were CD8-positive cells and were located in the portal tracts and parenchyma. CD4-positive T cells were scarce and confined to the portal tracts. Proliferation of fat-storing cells paralleled hepatocyte regeneration with maximal values after 48 to 72 hr. The temporal relationship between infiltrating mononuclear cells, mainly T lymphocytes of CD8 phenotype and macrophages, fat-storing cell proliferation and hepatic regeneration suggests pathophysiological interactions between these cell types in liver injury in the rat after galactosamine hydrochloride administration.
Femtosecond spectral relaxation of α-conjugated hexamethylsexithiophene in solution (1995)

The effects of ring rotation on both thermalization and decay kinetics of the excited state in methyl-substituted sexithiophene are investigated in solution by femtosecond pump and probe experiments. Electron-ring torsion coupling is proposed to play a fundamental role in leading to a slow spectral relaxation of the emitting state and driving the internal conversion to the ground state. Within our model, planarization of the excited state takes place in 4 ps in chloroform solution. The recovery of the excited-state population has been measured up to 500 ps in a broad range of probe wavelength from 490 nm up to 1 \ensuremath{\mu}m.
Stealth Fluorescence Labeling for Live Microscopy Imaging of mRNA Delivery (2021)

Methods for tracking RNA inside living cells without perturbing their natural interactions and functions are critical within biology and, in particular, to facilitate studies of therapeutic RNA delivery. We present a stealth labeling approach that can efficiently, and with high fidelity, generate RNA transcripts, through enzymatic incorporation of the triphosphate of tC<sup>O</sup>, a fluorescent tricyclic cytosine analogue. We demonstrate this by incorporation of tC<sup>O</sup> in up to 100% of the natural cytosine positions of a 1.2 kb mRNA encoding for the histone H2B fused to GFP (H2B:GFP). Spectroscopic characterization of this mRNA shows that the incorporation rate of tC<sup>O</sup> is similar to cytosine, which allows for efficient labeling and controlled tuning of labeling ratios for different applications. Using live cell confocal microscopy and flow cytometry, we show that the tC<sup>O</sup>-labeled mRNA is efficiently translated into H2B:GFP inside human cells. Hence, we not only develop the use of fluorescent base analogue labeling of nucleic acids in live-cell microscopy but also, importantly, show that the resulting transcript is translated into the correct protein. Moreover, the spectral properties of our transcripts and their translation product allow for their straightforward, simultaneous visualization in live cells. Finally, we find that chemically transfected tC<sup>O</sup>-labeled RNA, unlike a state-of-the-art fluorescently labeled RNA, gives rise to expression of a similar amount of protein as its natural counterpart, hence representing a methodology for studying natural, unperturbed processing of mRNA used in RNA therapeutics and in vaccines, like the ones developed against SARS-CoV-2.
Permanent-magnet linear alternators part 1: Fundamental equations (1987)

Powered by free-piston Stirling engines, linear alternators are proposed for space power stations as well as for isolated domestic applications, automotive, and on-Earth solar power plants. As the literature on the subject is sparse and base-design oriented, we present the general equations for both three-phase and single-phase winding configurations having permanent-magnet field excitations.
An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor (2014)

Systemic inflammatory myofibroblastic tumor is an exceedingly rare entity. A 45-year-old Hispanic female presented with a 6-month history of left-sided thigh pain, low back pain, and generalized weakness. PET/CT scan revealed abnormal activity in the liver, adrenal gland, and pancreas. MRI of the abdomen demonstrated two 6-7 cm masses in the liver. MRI of the lumbar spine demonstrated lesions in the L2 to L4 spinous processes, paraspinal muscles, and subcutaneous tissues, as well as an 8 mm enhancing intradural lesion at T11, all thought to be metastatic disease. A biopsy of the liver showed portal tract expansion by a spindle cell proliferation rich in inflammation. Tumor cells showed immunoreactivity for smooth muscle actin and anaplastic lymphoma kinase 1 (ALK1). Tissue from the L5 vertebra showed a process histologically identical to that seen in the liver. FISH analysis of these lesions demonstrated an ALK (2p23) gene rearrangement. The patient was successfully treated with an ALK-inhibitor, Crizotinib, and is now in complete remission. We present the first reported case, to our knowledge, of inflammatory myofibroblastic tumor with systemic manifestations and ALK translocation. This case is a prime example of how personalized medicine has vastly improved patient care through the use of molecular-targeted therapy.
In Vitro Propagation of Java, New Guinea, and Java x New Guinea Impatiens (1985)

Abstract In vitro propagation of induced tetraploid Java (J) Impatiens platypetala Lindl. TR6-19, New Guinea (NG) Impatiens sp. ‘Skyrocket’, and 2 interspecific J x NG hybrids, T63-1 and T63-3, was achieved by culturing shoot tips on agar-solidified MS revised medium supplemented with levels of kinetin and NAA. The mean number of shoots per shoot tip increased linearly from 0.3 shoots at 1.39 µM to 8.5 shoots at 139.0 µM kinetin for T63-1, the most responsive genotype. The number of shoots produced by T63-1 and T63-3 were not significantly different, but both hybrids produced significantly more shoots than either ‘Skyrocket’ or TR6-19. Shoot tips produced in vitro rooted readily and were transferred successfully to soil. Chemical name used: 1-naphthaleneacetic acid (NAA).
Optical limiters using photorefractive nonlinearities (1985)

We report experimental and theoretical studies of the use of the photorefractive effect in the design of optical limiters. Preliminary results indicate extinction coefficients of at least 98–99% with 1 J/cm2 transmitted before steady state is reached.
Customized SmartPeg for measurement of resonance frequency of mini dental implants (2017)

The new custom-made SmartPeg is suitable for measuring the Implant Stability Quotient of 3M™ESPE™MDIs. The primary stability of 3M™ESPE™MDIs is similar to the primary stability attained by standard implants in the rabbit tibia.
Indemics (2010)

To respond to the serious threat of pandemics (e.g. 2009 H1N1 influenza) to human society, we developed Indemics (<u>In</u>teractive Epi<u>demic</u> <u>S</u>imulation), an interactive, data intensive, high performance modeling environment for realtime pandemic planning, situation assessment, and course of action analysis. Indemics was built upon a model of interactive data intensive scientific computation, supporting online interactions between users and simulations and enabling epidemic simulations over detailed social contact networks and realistic representations of complex public policies and intervention strategies.
Application of Patient-Specific Computational Fluid Dynamics in Coronary and Intra-Cardiac Flow Simulations: Challenges and Opportunities (2018)

The emergence of new cardiac diagnostics and therapeutics of the heart has given rise to the challenging field of virtual design and testing of technologies in a patient-specific environment. Given the recent advances in medical imaging, computational power and mathematical algorithms, patient-specific cardiac models can be produced from cardiac images faster, and more efficiently than ever before. The emergence of patient-specific computational fluid dynamics (CFD) has paved the way for the new field of computer-aided diagnostics. This article provides a review of CFD methods, challenges and opportunities in coronary and intra-cardiac flow simulations. It includes a review of market products and clinical trials. Key components of patient-specific CFD are covered briefly which include image segmentation, geometry reconstruction, mesh generation, fluid-structure interaction, and solver techniques.
Characterization of Methylaluminoxanes and Determination of Trimethylaluminum Using Proton NMR (1998)

New methods for characterization of methylaluminoxanes (MAO) and determination of trimethylaluminum (TMA) using proton NMR are reported. Addition of excess perdeuteriotetrahydrofuran to sharpen and shift the TMA peak followed by curve fitting to remove residual overlap between the TMA and MAO peaks allows accurate, precise, and rapid quantitation of TMA and MAO in solution. The analysis also provides determination of all the solution components of MAO preparations and the number of methyl groups per aluminum in MAO when combined with an independent determination of the aluminum content.
Multi-Party WebRTC Services Using Delay and Bandwidth Aware SDN-Assisted IP Multicasting of Scalable Video Over 5G Networks (2019)

At present, multi-party WebRTC videoconferencing between peers with heterogenous network resources and terminals is enabled over the best-effort Internet using a central selective forwarding unit (SFU), where each peer sends a scalable encoded video stream to the SFU. This connection model avoids the upload bandwidth bottleneck associated with mesh connections; however, it increases peer delay and overall network load (resource consumption) in addition to requiring investment in servers since all video traffic must go through SFU servers. To this effect, we propose a new multi-party WebRTC service model over future 5G networks, where a video service provider (VSP) collaborates with a network service providers (NSP) to offer an NSP-managed service to stream scalable video layers using software-defined networking (SDN)-assisted Internet protocol (IP) multicasting between peers using NSP infrastructure. In the proposed service model, each peer sends a scalable coded video upstream, which is selectively duplicated and forwarded as layer streams at SDN switches in the network, instead of at a central SFU, in a multi-party WebRTC session managed by multicast trees maintained by the SDN controller. Experimental results show that the proposed SDN-assisted IP multicast service architecture is more efficient than the SFU model in terms of end-to-end service delay and overall network resource consumption, while avoiding peer upload bandwidth bottleneck and distributing traffic more evenly across the network. The proposed architecture enables efficient provisioning of premium managed WebRTC services over bandwidth-reserved SDN slices to provide videoconferencing experience with guaranteed video quality over 5G networks.
A MINSAT Approach for Learning in Logic Domains (2002)

This paper describes a method for learning logic relationships that correctly classify a given data set. The method derives from given logic data certain minimum cost satisfiability problems, solves these problems, and deduces from the solutions the desired logic relationships. Uses of the method include data mining, learning logic in expert systems, and identification of critical characteristics for recognition systems. Computational tests have proved that the method is fast and effective.
Pressure Test: Quantifying the impact of positive stress on companies from online employee reviews (2021)

Workplace stress is often considered to be negative, yet lab studies on individuals suggest that not all stress is bad. There are two types of stress: distress refers to harmful stimuli, while eustress refers to healthy, euphoric stimuli that create a sense of fulfillment and achievement. Telling the two types of stress apart is challenging, let alone quantifying their impact across corporations. By leveraging a dataset of 440K reviews about S&amp;P 500 companies published during twelve successive years, we developed a deep learning framework to extract stress mentions from these reviews. We proposed a new methodology that places each company on a stress-by-rating quadrant (based on its overall stress score and overall rating on the site), and accordingly scores the company to be, on average, either a low stress}, passive, negative stress, or positive stress company. We found that (former) employees of positive stress companies tended to describe high-growth and collaborative workplaces in their reviews, and that such companies' stock evaluations grew, on average, 5.1 times in 10 years (2009-2019) as opposed to the companies of the other three stress types that grew, on average, 3.7 times in the same time period. We also found that the four stress scores aggregated every year -- from 2008 to 2020 -- closely followed the unemployment rate in the U.S.: a year of positive stress (2008) was rapidly followed by several years of negative stress (2009-2015), which peaked during the Great Recession (2009-2011). These results suggest that automated analyses of the language used by employees on corporate social-networking tools offer yet another way of tracking workplace stress, allowing quantification of its impact on corporations.
Breast Reconstruction with the Free TRAM or DIEP Flap: Patient Selection, Choice of Flap, and Outcome (2002)

Recent reports of breast reconstruction with the deep inferior epigastric perforator (DIEP) flap indicate increased fat necrosis and venous congestion as compared with the free transverse rectus abdominis muscle (TRAM) flap. Although the benefits of the DIEP flap regarding the abdominal wall are well documented, its reconstructive advantage remains uncertain. The main objective of this study was to address selection criteria for the free TRAM and DIEP flaps on the basis of patient characteristics and vascular anatomy of the flap that might minimize flap morbidity. A total of 163 free TRAM or DIEP flap breast reconstructions were performed on 135 women between 1997 and 2000. Four levels of muscle sparing related to the rectus abdominis muscle were used. The free TRAM flap was performed on 118 women, of whom 93 were unilateral and 25 were bilateral, totaling 143 flaps. The DIEP flap procedure was performed on 17 women, of whom 14 were unilateral and three were bilateral, totaling 20 flaps. Morbidities related to the 143 free TRAM flaps included return to the operating room for 11 flaps (7.7 percent), total necrosis in five flaps (3.5 percent), mild fat necrosis in 14 flaps (9.8 percent), mild venous congestion in two flaps (1.4 percent), and lower abdominal bulge in eight women (6.8 percent). Partial flap necrosis did not occur. Morbidities related to the 20 DIEP flaps included return to the operating room for three flaps (15 percent), total necrosis in one flap (5 percent), and mild fat necrosis in two flaps (10 percent). Partial flap necrosis, venous congestion, and a lower abdominal bulge were not observed. Selection of the free TRAM or DIEP flap should be made on the basis of patient weight, quantity of abdominal fat, and breast volume requirement, and on the number, caliber, and location of the perforating vessels. Occurrence of venous congestion and total flap loss in the free TRAM and DIEP flaps appears to be independent of the patient age, weight, degree of muscle sparing, and tobacco use. The occurrence of fat necrosis is related to patient weight (p < 0.001) but not related to patient age or preservation of the rectus abdominis muscle. The ability to perform a sit-up is related to patient weight (p < 0.001) and patient age (p < 0.001) but not related to preservation of the muscle or intercostal nerves. The incidence of lower abdominal bulge is reduced after DIEP flap reconstruction (p < 0.001). The DIEP flap can be an excellent option for properly selected women.
Catalytic Activity of Rh Nanoparticles with High-index Faces for Hydrogen Evolution Reaction in Alkaline Solution (2019)

Rh nanoparticles (NPs) with various shapes exposing different faces were synthesized and their catalytic activities for hydrogen evolution reaction (HER) were investigated. Rh NPs showed a shape dependence on the catalytic activities and the activity of Rh NPs with high-index faces was higher than the others. Rh nanoparticles with various shapes exposing different faces were synthesized and their catalytic activities for hydrogen evolution reaction (HER) were investigated. Rh NPs showed a shape dependence on the catalytic activities for HER in alkaline solution and the catalytic activity of Rh NPs with high-index faces was higher than Rh NPs with low-index faces.