gebhart/patrepeval huggingface dataset:
SEMICONDUCTOR SWITCHES FOR SINGLE PULSE AND REPETITIVE PULSE APPLICATIONS (2001)

An overview is given about solid state pulse power switches which are designed for single pulse applications i.e. launch systems (ET or EM Guns) and active armour. Also a newly developed switching system is presented which can be used for repetition frequencies up to 400 Hz, high di/dt, up to 20 kVdc and pulse currents of over 15 kA, designed for laser applications. (Solid State alternative for Thyratrons) By using a modular platform technology, a variation of four standardized silicon wafer sizes can be selected to reach the required current and di/dt levels, and by stacking devices in series connection, voltages of up to 50 kV can be realized. The presented switches and components are including the triggering system, and where required, also including power supply and heatsinks.
High spatiotemporal resolution in multifocal processing with femtosecond laser pulses (2006)

We report spatial and temporal dispersion compensation for fan-out of femtosecond pulses with a low-frequency diffraction grating by means of a hybrid diffractive-refractive lens triplet. In this way, we achieve a multifocal light structure with nearly diffraction-limited light spots even for 20 fs pulse duration. The spatial chromatic compensation, which drastically reduces the lateral walk-off of the various spectral components, also allows us to improve the available bandwidth at the dispersion-compensated diffraction orders. In fact, the temporal width of the output pulse is essentially limited by the group-delay dispersion term, which is shown to be small. The high spatiotemporal resolution provided by our proposal permits parallel multifocal processing of materials with femtosecond pulses.
Characterization of nonlinear optical properties of graphene at telecommunication wavelength (2013)

info:eu-repo/semantics/published
“I'm Created in God's Image, and God Don't Create Junk”: Religious Participation and Support Among Older GLBT Adults (2013)

There is an emerging literature on the integration of sexual and religious identities among gay, lesbian, bisexual, and transgender (GLBT) adults. However, this work has not assessed the experiences of GLBT adults 50 and older, whose life course issues and social care needs are different than younger members of this population. Using qualitative methods, we explored the religious engagement of 210 older GLBT adults, and examined the support received from their religious congregations. Results identified intrinsic and extrinsic adaptational strategies that facilitate high levels of religious engagement, as well as considerable congregational support. Implications for research and practice are discussed.
Antigen-Specific B-Cell Responses to Porcine Reproductive and Respiratory Syndrome Virus Infection (2007)

Porcine reproductive and respiratory syndrome virus (PRRSV) causes an acute, viremic infection of 4 to 6 weeks, followed by a persistent infection lasting for several months. We characterized antibody and B-cell responses to viral proteins in acute and persistent infection to better understand the immunological basis of the prolonged infection. The humoral immune response to PRRSV was robust overall and varied among individual viral proteins, with the important exception of a delayed and relatively weak response to envelope glycoprotein 5 (GP5). Memory B cells were in secondary lymphoid organs, not in bone marrow or Peyer's patches, in contrast to the case for many mammalian species. Potent anti-PRRSV memory responses were elicited to recall antigen in vitro, even though a second infection did not increase the B-cell response in vivo, suggesting that productive reinfection does not occur in vivo. Antibody titers to several viral proteins decline over time, even though abundant antigen is known to be present in lymphoid tissues, possibly indicating ineffective antigen presentation. The appearance of antibodies to GP5 is delayed relative to the resolution of viremia, suggesting that anti-GP5 antibodies are not crucial for resolving viremia. Lastly, viral infection had no immunosuppressive effect on the humoral response to a second, unrelated antigen. Taking these data together, the active effector and memory B-cell responses to PRRSV are robust, and over time the humoral immune response to PRRSV is effective. However, the delayed response against GP5 early in infection may contribute to the prolonged acute infection and the establishment of persistence.
Technical-economic cost modeling as a technology management tool (2014)

Purpose – The purpose of this paper is to show how technical-economical cost modeling can help in steering research and development to target key production cost elements of new products based on emerging technologies. Design/methodology/approach – The authors demonstrate the development and use of a technical-economic cost model (TCM) of the proton exchange membrane (PEM) in fuel cells to steer research to produce more economical and reliable products. A TCM is developed to depict how the production cost per unit varies depending on the different fabrication methods, production rate limitations, material selection, labor distribution, energy consumption, financial parameters and the target production volume. By using such an approach in the design, research time and resources can be saved by prioritizing R&amp;D and production scale-up options at an early stage. Findings – The results of this study show the importance of applying technical-economic cost model (TCM) techniques on early stage research projects to steer the development for resolving key problematic figures. As a case study, a cost analysis platform has been established to apply this technique by analyzing different manufacturing and R&amp;D options for producing durable PEM fuel cells. The projected manufacturing cost of the PEM is found to be lower than previously estimated and the enhanced durability does not significantly impact this production cost. Originality/value – Production is an important factor in informing NPD targets and R&amp;D direction. And yet it is difficult to estimate scaled up production cost for prototype products and components in the R&amp;D lab. Technical-economic cost models (TCM) are a tool to assist decision-making in technology portfolio management and NPD.
Introduction (1980)

Few Chinese writers have distinguished themselves in as many genres as Yü Hsin (513–81). Yü's lyric poetry is fully equal to that of Hsieh Ling-yün (385–433), for example. His parallel-prose writings are considered models of that form, so much so, in fact, that his name has become more or less synonymous with parallel prose. Finally, Yü's fifteen surviving fu, or poems in irregular meter, include several works of the first rank, and one of them, ‘The Lament for the South’ (‘Ai Chiang-nan fu’), is probably the finest fu ever written. It is mainly with the ‘Lament’ that this book is concerned.
Spin physics for high intensity hadron facility (1985)

Abstract This paper has the purpose of giving a broad survey of the potential of spin physics at a high intensity, 20–30 GeV machine, by summarizing the status of present experimental techniques and physics problems. Potentially polarization experiments give detailed information which is lost in unpolarized measurements. The interest of optimized polarized beams and targets are considered from various points of view, reflecting the interplay of experimental information and theoretical understanding associated with the role of spin in elementary particle physics.
The Impact Behavior of the Hybrid II Dummy (1975)

&lt;div class="htmlview paragraph"&gt;The head, chest and femurs of three Hybrid II dummies were impacted with a ballistic pendulum at various angles to determine what differences in accelerometer and femur load cell output would result for a constant energy input. Also evaluated were suspicious tension loads in the femur load cell output when the legs were subjected to obvious off-center impacts during crash tests. It was found that the dummy legs can be subjected to very high torsion and bending loads which can have a significant effect on the femur load cell axial load outputs.&lt;/div&gt;
ChIP‐based methods for the identification of long‐range chromatin interactions (2009)

Chromatin immunoprecipitation (ChIP) is an important technique for studying protein-DNA interactions. Whole genome ChIP methods have enjoyed much success, but are limited in that they cannot uncover important long-range chromatin interactions. Chromosome conformation capture (3C) and related methods are capable of detecting remote chromatin interactions, but are tedious, have low signal-to-noise ratios, and are not genome-wide. Although the addition of ChIP to 3C (ChIP-3C) would conceivably reduce noise and increase specificity for chromatin interaction detection, there are concerns that simple mixing of the ChIP and 3C protocols would lead to high levels of false positives. In this essay, we dissect current ChIP- and 3C-based methodologies, discuss the models of specific as opposed to non-specific chromatin interactions, and suggest approaches to separate specific chromatin complexes from non-specific chromatin fragments. We conclude that the combination of sonication-based chromatin fragmentation, ChIP-based enrichment, chromatin proximity ligation and Paired-End Tag ultra-high-throughput sequencing will be a winning implementation for genome-wide, unbiased and de novo discovery of long-range chromatin interactions, which will help to establish an emerging field for studying human chromatin interactomes and genome regulation networks in three-dimensional spaces.
Solar System as it really is and Curating as/in Common/s (2013)

&#x0D; &#x0D; &#x0D; In this proposition of curating in/as common/s I am interested in a particular relation between curating and commons. I claim that there is a link between curating and ‘commoning’, that is the activity and process that produces the commons, and that this link is based in practice. It lays in the fact that the two employ forms of organisation, a particular kind of arrangement of social and aesthetic relations, space, time, forms of behaviour, customs, and ways in which these are governed and controlled, in other words the way in which they are held in common. When we say that something is curated the understanding is that we are dealing with a collection assembled and displayed accord- ing to a curatorial vision and under curator’s direction. Regardless if we are dealing with an übercurator with total control over exhibition, or if the curator’s role is instrumental in delivering the museum’s mission, or if indeed collaborative forms of curating or co-curating are engaged in process of curatorial production, a curator can be considered an apparatus of power, a dispositif in a Foucauldian sense. A different form of organisation is in- voked, however, when we refer to commons which are understood as a self-organised community shaping, managing and utilising resources through ‘community control’.&#x0D; &#x0D; &#x0D;
Nanometer Trench Fabricated by Atomic Force Microscopy (2004)

Nanometer trenches were successfully produced by NaOH etching of the Ti oxide lines produced by atomic force microscopy (AFM) anodization on Ti thin films of 6 nm thickness on Si thermal oxidation films. The full width at half maximum (FWHM) of a nanometer trench is estimated to be approximately 20 nm, which is comparable to the radius of curvature of the AFM cantilever. It is found that the etching rate of the Ti oxide lines produced by AFM anodization depends on oxide lines height. The selection ratio of etching rate of the Ti thin film and oxide lines is 10 for oxide lines of 2 nm height, the etching rates being approximately 0.08 and 0.87 nm/min, respectively. Ti nanometer wires having 20 nm FWHM could be formed from two nanometer trenches placed close together in parallel.
Two-axis solar tracking accomplished through small lateral translations (2012)

High-concentration solar-power optics require precise two-axis tracking. The planar micro-optic solar concentrator uses a lenslet array over a planar waveguide with small reflective facets at the focal point of each lenslet to couple incident light into the waveguide. The concentrator can use conventional tracking, tilting the entire assembly, but the system geometry also allows tracking by small lateral translation of the lenslet relative to the waveguide. Here, we experimentally demonstrate such microtracking with the existing concentrator optics and present optimized optical designs for systems with higher efficiency and angle range.
Ways to manage risk (2020)

While the priority is to ensure that staff and families feel safe as children begin to return after the coronavirus lockdown, this will involve settings making changes to their policies and procedures.
Development of electromagnetic MEMS motor without winding wire and application to microrobot (2016)

This paper proposes an electromagnetic MEMS motor without a winding wire. The developed motor is combined with microelectromechanical systems (MEMS) processing and multilayer ceramic technology, which is used to form a miniature three-dimensional coil inside the magnetic core. The length, width, and height of the developed motor are 11, 11, and 7.5 mm, respectively. The fabricated MEMS motor demonstrated rotational motion, with a rotational speed of 480 rpm at 0.42 V and 280 mA. Moreover, a microrobot based on the developed MEMS motor is presented. The silicon structure of the developed motor is used as a structural component of the microrobot. The single rotor of the motor will produce footstep motion through a simple mechanical system.
Figure S5 from Development of a Tetravalent Anti-GPA33/Anti-CD3 Bispecific Antibody for Colorectal Cancers (2023)

&lt;p&gt;Figure S5 shows the results of affinity maturation of huA33-BsAb&lt;/p&gt;
Absolute Rate Constants for α-Amide Radical Reactions (1998)

The 1-(diethylcarbamoyl)-6,6-diphenyl-5-hexenyl radical (4a), the 1-(diethylcarbamoyl)-7,7-diphenyl-6-heptenyl radical (4b), and the 1-(diethylcarbamoyl)-1-methyl-6,6-diphenyl-5-hexenyl radical (4c) were produced from the corresponding PTOC esters (anhydrides of the carboxylic acid and N-hydroxypyridine-2-thione) by laser flash photolysis methods. The kinetics of cyclizations of radicals 4a and 4b were measured at various temperatures, and that of cyclization of 4c was measured at ambient temperature. Radicals 4a and 4b were employed as radical clocks in indirect kinetic studies to determine rate constants for reaction of secondary alpha-amide radicals with Bu(3)SnH. The calibrated tin hydride trapping reaction was then employed to determine rate constants for cyclization of the 1-(diethylcarbamoyl)-5-hexenyl radical (12). The rate constants for 5-exo cyclizations of secondary alpha-amide radicals are similar to those of their isostructural alkyl radical analogues. The rate constants for the 5-exo cyclization of tertiary alpha-amide radical 4c and the 6-exo cyclization of the secondary alpha-amide radical 4b are smaller than those of the analogous alkyl radicals and alpha-ester substituted radicals, apparently due to steric effects. The rate constants for tin hydride trapping of secondary alpha-amide radicals are similar to those for reactions with secondary alpha-ester radicals.
Studies on a Wearable, Electronic, Transdermal Alcohol Sensor (1992)

The measurement of alcohol consumption over long time periods is important for monitoring treatment outcome and for research applications. Giner, Inc. has developed a wearable device that senses ethanol vapor at the surface of the skin, using an electrochemical cell that produces a continuous current signal proportional to ethanol concentration. A thermistor monitors continuous contact of the sensor with the skin, and a data-acquisition/logic circuit stores days of data recorded at 2- to 5-min intervals. Testing of this novel ethanol sensor/recorder was conducted on nonalcoholic human subjects consuming known quantities of ethanol and on intoxicated alcoholic subjects. The transdermal sensor signal closely follows the pattern of the blood alcohol concentration curve, although with a delay. This paper describes the concept of electrochemical ethanol measurement and presents some of the clinical data collected in support of the sensor/recorder development.
Dysregulation of the γδ T cell repertoire in patients with acute leukemia: Implications for cellular immunotherapy (2005)

Introduction: Despite their relatively small numbers, γδ T cells have significant innate anti-tumor activity. This is principally due to their ability to respond, without prior exposure or priming, to a broad array of stress-associated antigens commonly displayed on malignant cells. Our laboratory has shown increased allogeneic γδ T cells to have a protective effect against relapse in patients transplanted for leukemia, and that γδ T cells are not associated with increased risk of graft versus host disease in these patients. In order to gain insight into the nature of a potential antileukemic effect of γδ T cells, we sought to determine if evidence existed for an autologous γδ T cell immune response in pre-treatment leukemia patients. Methods: We first examined the γδ T cell receptor (TCR) phenotype and complementarity determining region 3 (CDR3) cDNA sequence from 17 leukemia patients and 3 healthy controls to determine the γδ TCR repertoire and clonality. Following this, we cultured γδ T cells from healthy first degree relatives with the corresponding patients’ primary leukemic blasts. We then examined γδ T cell proliferation and TCR repertoire at weekly intervals and cytotoxicity to patient blasts after 3–4 weeks of culture and compared these results with co-cultures of γδ T cells from healthy volunteers and normal allogenic mononuclear cells (MNC). Results: All patients and healthy volunteers had normal absolute γδ T cell counts. In 15/17 patients, Vδ1+ γδ T cells were predominant, in contrast to Vδ2+ predominance in healthy volunteers. Vδ1 CDR3-region cDNA sequence analysis revealed that leukemia patients exclusively used the Jδ1 constant region, with healthy controls showing both Jδ1 and Jδ2 use. Two patients with APL showed significant CDR3 conservation as did one B-ALL and one T-ALL patient. When fresh allogeneic γδ T cells were cultured with primary patient blasts, Vδ2+ T cells were quickly deleted and Vδ1+ T cells proliferated and in 4 instances were able to lyse primary blasts. Insignificant γδ T cell proliferation was observed in cultures with normal MNC. Conclusions: These findings point to a complex dysregulation in the γδ T cell compartment in leukemia patients including deletion of the Vδ2 subtype in vitro and in vivo and a Vδ1+ T cell response to leukemia in vivo. These findings suggest consideration of allogeneic γδ T cell therapy as part of a comprehensive immunotherapeutic strategy for acute leukemia.
(S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonist (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT(S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonistSven Erik Hillver, Lena Bjoerk, Yi Lin Li, Bjoern Svensson, Svante Ross, Nils Erik Anden, and Uli HacksellCite this: J. Med. Chem. 1990, 33, 6, 1541–1544Publication Date (Print):June 1, 1990Publication History Published online1 May 2002Published inissue 1 June 1990https://pubs.acs.org/doi/10.1021/jm00168a002https://doi.org/10.1021/jm00168a002research-articleACS PublicationsRequest reuse permissionsArticle Views312Altmetric-Citations90LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
OVERVIEW OF PLATOONING SYSTEMS (2012)

This paper presents an overview of current projects that deal with vehicle platooning. The platooning concept can be defined as a collection of vehicles that travel close together, actively coordinated in formation. Some expected advantages of platooning include increased fuel and traffic efficiency, safety and driver comfort. There are many variations of the details of the concept such as: the goals of platooning, how it is implemented, mix of vehicles, the requirements on infrastructure, what is automated (longitudinal and lateral control) and to what level. The following projects are presented: SARTRE a European platooning project; PATH a California traffic automation program that includes platooning; GCDC a cooperative driving initiative, and; Energy ITS a Japanese truck platooning project.
Optical clearing and multimodality fluorescence and magnetic resonance imaging in cancer models (2021)

Optical clearing (OC) increases the depth of light penetration and improves the outcomes of optical imaging measurements in situ and in vivo. In vivo OC protocols have to be biocompatible and should result in transient effects with minimal long-term damage to the tissues. The effects of various OC compositions in vivo were previously studied by using primarily optical imaging. Multimodality registration of optical and magnetic resonance imaging (MRI) signals in the same voxels of live tissue could be useful for improving accuracy of optical image reconstruction. We investigated OC effects on fluorescence intensity (FI) imaging of red fluorescent TagRFP protein marker in tumor cells and combined it with MRI. The OC effects of diamagnetic glycerol/DMSO/water and a paramagnetic magnetic resonance (MR) imaging agent (gadobutrol) and its mixtures were measured by using whole body FI, a single-photon counting FI setup and three MRI pulse sequences: 1) T2-weighted fast spin-echo; 2) diffusion-weighted and 2) 3D gradient-echo. A time-dependent increase of TagRFP FI resulted in tumor FI/skin ratio improvement at 15-30 min after OC. 0.7M solution of gadobutrol in DMSO/water was more efficient than 1.M gadobutrol (30-35% vs.15-20% increase of FI). The observed MRI signal intensity changes were most likely due to a combination of several effects, i.e. 1) longitudinal proton relaxation time shortening in subcutaneous tumor; 2) magnetic susceptibility effects of gadobutrol; 3) transient increase of T1w signal due to gadobutrol penetration through the skin and dilution in extracellular volume. The obtained results indicate that MRI can be instrumental in enabling mechanistic studies of OC effects in the skin and peripheral subcutaneous tissue.
1009 Analysis of Aerodynamic Sound Sources in Wing Tip Flow and Prediction of Far-field Sound generated from the Flow (2010)

This paper presents the prediction of the aerodynamic sound sources and the far-field sound on the wing-tip flow. Analysis object is NACA0012 of the lifting condition and Reynolds number based on chord length and uniform velocity is 2×10^5. The aerodynamic sound sources were calculated using incompressible LES (Large-Eddy Simulation) with 40 million grid points around the wing. Distribution of ∂T_<ij>/∂X_i∂X_j indicated that the sound source exist on the wing-tip. The far-field sound predicted by lihgthill tensor showed that the contribution into the airfoil noise by the sound generated from wing-tip flow is small at the Strouhal number 6 to 11.25 Hz.