gebhart/patrepeval huggingface dataset:
The Healthy Effects of Strawberry Polyphenols: Which Strategy behind Antioxidant Capacity? (2015)

Current evidence indicates that the consumption of strawberries, a natural source of a wide range of nutritive and bioactive compounds, is associated with the prevention and improvement of chronic-degenerative diseases. Studies involving cells and animals provide evidence on the anti-inflammatory, anticarcinogenic and antiproliferative activity of the strawberry. Epidemiological and clinical studies demonstrate that its acute consumption increases plasma antioxidant capacity, improves circulating inflammatory markers and ameliorates postprandial glycemic response. At the same time, a protracted intake reduces chronic inflammation and improves plasma lipid profile, supporting cardiovascular health, especially in individuals with increased risk for metabolic syndrome. To explain these beneficial effects, much attention has been paid in the past to the antioxidant properties of strawberry polyphenols. However, recent research has shown that their biological and functional activities are related not only to the antioxidant capacity but also to the modulation of many cellular pathways involved in metabolism, survival, proliferation, and antioxidant defenses. The aim of this review is to update and discuss the molecular and cellular mechanisms proposed in recent studies to elucidate the healthy effects of strawberry polyphenols against the most common chronic diseases, such as cancer, cardiovascular diseases, metabolic syndrome, and inflammation.
Polycondensation rate of poly(ethylene terephthalate). I. Polycondensation catalyzed by antimony trioxide in presence of reserve reaction (1968)

Abstract The technique of G. Challa was employed for following the reaction of oligomeric poly(ethylene terephthalate) in the presence of antimony trioxide. This technique is based on determining the changes in glycol and bishydroxyethyl terephthalate concentrations with time at a given temperature. The linear trimer of ethylene terephthalate, prepared from terephthaloyl chloride and bishydroxyethyl terephthalate, was employed as starting material. Rate constants were not corrected for catalyst concentrations. The reaction was studied over the temperature range 221–251°C. The equilibrium constant k p / k ′ for the polycondensation reaction magnified image was found to be 0.36. Observed reaction rates were low but faster than in the uncatalyzed reaction studied by Challa. At 231°C. the values of the rate constants found in the presence of 0.025% by weight antimony trioxide were k p = 0.151.mole −1 hr. −1 and k ′ = 0.33 l./mole‐hr., and the redistribution rate constant was k R = 0.11 l./mole‐hr. From data at four temperatures the estimated activation energies were E p = 29 kcal. and E R = 24 kcal. The polycondensation rates were low compared with rates calculated from literature data. A mechanism to explain the difference requires that bishydroxyethyl terephthalate endgroups compete successfully with oligomer endgroups for antimony trioxide catalyst and that the bishydroxyethyl terephthalate catalyst product is unreactive in polymerization.
Taxonomic Study of the East Palaearctic GenusCardipennisKorotyaev (Coleoptera: Curculionidae: Ceutorhynchinae) (2018)

The genus Cardipennis Korotyaev, 1980 (Ceutorhynchinae: Ceutorhynchini) was studied on the basis of detailed morphological observations of various materials. Different scale patterns within a species are found for all the three species. Based on the external morphology and genitalia characteristics, Cardipennis rubripes (Hustache, 1916), C. sulcithorax (Hustache, 1916), and C. shaowuensis (Voss, 1958) are redescribed, with new records of C. rubripes from mainland China. Cardipennis species are mainly associated with annual herbs of Cannabis and Humulus (Cannabaceae). A key to species, habitus photographs, and illustrations of important characters are provided for each species. Distribution maps of the three species are also given.
Etude préparatoire à la réutilisation de chaînes (2002)

National audience
Simulated Interactions between Angiotensin-Converting Enzyme and Substrate Gonadotropin-Releasing Hormone:  Novel Insights into Domain Selectivity (2007)

Human angiotensin-I converting enzyme (ACE) is a central component of the renin-angiotensin system and a major target for cardiovascular therapies. The somatic form of the enzyme (sACE) comprises two homologous metallopeptidase domains (N and C), each bearing a zinc active site with similar but distinct substrate and inhibitor specificities. On the basis of the recently determined crystal structures of both ACE domains, we have studied their complexes with gonadotropin-releasing hormone (GnRH), which is cleaved releasing both the protected NH2- and COOH-terminal tripeptides. This is the first molecular modeling study of an ACE-peptide substrate complex that examines the structural basis of ACE's endopeptidase activity and offers novel insights into subsites that are distant from the obligatory binding site and were not identified in the crystal structures. Our data indicate that a bridging interaction between Arg500 of the N-domain and Arg8 of GnRH that involves a buried chloride ion may account for its role in the specificity of the N-domain for endoproteolytic cleavage of the substrate at the NH2-terminus in vitro. In support of this, the protected NH2-terminal dipeptide of GnRH exhibits stronger interactions than the protected COOH-terminal dipeptide with the N-domain of ACE. Further comparison of the models of ACE-substrate complexes promotes our understanding of how the two domains differ in their function and specificity and provides an extension of the pharmacophore model used for structure-based drug design up to the S7 subsite of the enzyme.
Physics at BES-III (2008)

This physics book provides detailed discussions on important topics in $\tau$-charm physics that will be explored during the next few years at \bes3 . Both theoretical and experimental issues are covered, including extensive reviews of recent theoretical developments and experimental techniques. Among the subjects covered are: innovations in Partial Wave Analysis (PWA), theoretical and experimental techniques for Dalitz-plot analyses, analysis tools to extract absolute branching fractions and measurements of decay constants, form factors, and CP-violation and \DzDzb-oscillation parameters. Programs of QCD studies and near-threshold tau-lepton physics measurements are also discussed.
Integrated Circuits Based on Bilayer MoS2 Transistors (2012)

Two-dimensional (2D) materials, such as molybdenum disulfide (MoS(2)), have been shown to exhibit excellent electrical and optical properties. The semiconducting nature of MoS(2) allows it to overcome the shortcomings of zero-bandgap graphene, while still sharing many of graphene's advantages for electronic and optoelectronic applications. Discrete electronic and optoelectronic components, such as field-effect transistors, sensors, and photodetectors made from few-layer MoS(2) show promising performance as potential substitute of Si in conventional electronics and of organic and amorphous Si semiconductors in ubiquitous systems and display applications. An important next step is the fabrication of fully integrated multistage circuits and logic building blocks on MoS(2) to demonstrate its capability for complex digital logic and high-frequency ac applications. This paper demonstrates an inverter, a NAND gate, a static random access memory, and a five-stage ring oscillator based on a direct-coupled transistor logic technology. The circuits comprise between 2 to 12 transistors seamlessly integrated side-by-side on a single sheet of bilayer MoS(2). Both enhancement-mode and depletion-mode transistors were fabricated thanks to the use of gate metals with different work functions.
Regulatory T cells in multiple sclerosis and myasthenia gravis (2017)

Multiple sclerosis (MS) is a chronic debilitating disease of the central nervous system primarily mediated by T lymphocytes with specificity to neuronal antigens in genetically susceptible individuals. On the other hand, myasthenia gravis (MG) primarily involves destruction of the neuromuscular junction by antibodies specific to the acetylcholine receptor. Both autoimmune diseases are thought to result from loss of self-tolerance, which allows for the development and function of autoreactive lymphocytes. Although the mechanisms underlying compromised self-tolerance in these and other autoimmune diseases have not been fully elucidated, one possibility is numerical, functional, and/or migratory deficits in T regulatory cells (Tregs). Tregs are thought to play a critical role in the maintenance of peripheral immune tolerance. It is believed that Tregs function by suppressing the effector CD4+ T cell subsets that mediate autoimmune responses. Dysregulation of suppressive and migratory markers on Tregs have been linked to the pathogenesis of both MS and MG. For example, genetic abnormalities have been found in Treg suppressive markers CTLA-4 and CD25, while others have shown a decreased expression of FoxP3 and IL-10. Furthermore, elevated levels of pro-inflammatory cytokines such as IL-6, IL-17, and IFN-γ secreted by T effectors have been noted in MS and MG patients. This review provides several strategies of treatment which have been shown to be effective or are proposed as potential therapies to restore the function of various Treg subsets including Tr1, iTr35, nTregs, and iTregs. Strategies focusing on enhancing the Treg function find importance in cytokines TGF-β, IDO, interleukins 10, 27, and 35, and ligands Jagged-1 and OX40L. Likewise, strategies which affect Treg migration involve chemokines CCL17 and CXCL11. In pre-clinical animal models of experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune myasthenia gravis (EAMG), several strategies have been shown to ameliorate the disease and thus appear promising for treating patients with MS or MG.
Selectivity Enhancement in Heterogeneous Photocatalytic Transformations (2017)

Photocatalysis has been invariably considered as an unselective process (especially in water) for a fairly long period of time, and the investigation on selective photocatalysis has been largely neglected. In recent years, the field of selective photocatalysis is developing rapidly and now extended to several newer applications. This review focuses on the overall strategies which can improve the selectivity of photocatalysis encompassing a wide variety of photocatalysts, and modifications thereof, as well as the related vital processes of industrial significance such as reduction and oxidation of organics, inorganics, and CO<sub>2</sub> transformation. Comprehensive and successful strategies for enhancing the selectivity in photocatalysis are abridged to reinvigorate and stimulate future investigations. In addition, nonsemiconductor type photocatalysts, such as Ti-Si molecular sieves and carbon quantum dots (CQDs), are also briefly appraised in view of their special role in special selective photocatalysis, namely epoxidation reactions, among others. In the end, a summary and outlook on the challenges and future directions in the research field are included in the comprehensive review.
Concomitant presence of Aspergillus fumigatus and Stenotrophomonas maltophilia in the respiratory tract: a new risk for patients with liver disease? (2016)

Concomitant lung colonization by Aspergillus fumigatus and Stenotrophomonas maltophilia was reported mainly in patients with cystic fibrosis (CF) and immunocompromised patients. The aim of the study was to assess the frequency of co-culture of A. fumigatus and S. maltophilia in respiratory samples of hospitalized patients, and to determine its associated factors. Between 2007 and 2011, all patients who had A. fumigatus in their respiratory samples were retrospectively enrolled in the study. Their clinical and laboratory data, including the presence of S. maltophilia in a respiratory sample, were collected within the same month. Of the 257 enrolled patients (372 respiratory samples), 71 % were immunocompromised and 32 % had chronic respiratory disease. S. maltophilia was isolated within the same month in 20 patients (7.8 %). In the univariate analysis, factors associated with concomitant culture of A. fumigatus and S. maltophilia were liver disease (P = 0.009), orotracheal intubation (P = 0.001), ventilator-associated pneumonia (P = 0.006), central venous catheter (P = 0.003), parenteral nutrition (P = 0.008) and culture of Pseudomonas aeruginosa in respiratory samples (P = 0.002). In the multivariate analysis, the simultaneous presence of P. aeruginosa in the respiratory tract (odds ratio (OR) = 3.19, 95 % confidence interval (CI) 1.11-9.14, P = 0.031), liver disease (OR = 3.92, 95 % CI 1.32-11.62, P = 0.014) and orotracheal intubation (OR = 3.42, 95 % CI 1.17-9.96, P = 0.024) were independently associated with the co-culture of S. maltophilia and A. fumigatus. Factors independently associated with the concomitant culture of A. fumigatus and S. maltophilia were identified. These results support a future prospective study focusing on liver disease and its complications.
Adaptive 3D texture streaming in M3G-based mobile games (2012)

With the growing demand of mobile applications and games, one of the challenges is how to efficiently transmit the bulky 3D information to bandwidth- and computationally-limited mobile devices. In this paper, we propose two methods for improving the transmission delay of M3G-based 3D mobile game content over unreliable and congested networks. We introduce Object Mesh Similarity as a server side approach, in which we try to detect an alternative object with minimum complexities that is similar to the original object, and then transmit this reconstructed object, as well as Texture Stretching as a client-side approach, which leads to the efficient receipt of object textures. Our results show 35% to 70% improvement in the transmission delay of 3D textures.
A novel automated separator based on dual energy gamma-rays transmission (2000)

The paper describes a novel automated separator, of which the key point is the determination of ash in coal by a technique based on the attenuation of dual energy γ-rays transmission. The technique is often used to determine the concentration of a higher atomic number (Z) component in a lower Z matrix. We designed a novel apparatus to realize the on-line non-contact measurement of ash in the virgin lump coal during the process of conveying. As a result, the gangues in the virgin lump coal are recognized by using a threshold ash method and removed by the pneumatic actuator. In this paper the principle of this measurement and the arrangement for separation are presented. Both the main factors affecting the dynamic determination and methods for reducing errors in analysis are also proposed. Furthermore, the experimental verification of the analysis has been conducted. The results are in good agreement with the theoretical analysis.
EXTH-16. LP-184, A NOVEL ALKYLATING AGENT, IS EFFECTIVE IN GLIOBLASTOMA (2021)

Abstract Temozolomide (TMZ) is currently the most effective standard-of-care chemotherapy based on its ability to prolong survival of patients with newly diagnosed MGMT-methylated GBM. Blood-brain barrier permeable agents effective against TMZ-resistant GBMs (i.e. recurrent GBM, MGMT unmethylated GBM) are desperately needed. Lantern Pharma is currently developing LP-184, a hydroxyurea methyl acylfulvene derivative of irofulven guided by its AI platform RADRⓇ analysis showing that tumor cell sensitivity to LP-184 correlates positively with genes commonly upregulated in GBM and either associated with TMZ resistance (e.g. MGMT, UGDH) or tumor promotion (e.g. EGFR, ANXA2). In an in vitro 3D model that mimics the human BBB, the apparent permeability for LP-184 was 1.53E-04 cm/s at 30 minutes, comparable to 1.72E-04 cm/s for TMZ under identical conditions. LP-184 predominantly alkylates DNA at 3’-adenine predicting insensitivity to MGMT expression. In vitro cell toxicity assays in a panel of GBM cell lines and neurospheres reveal an IC50 range of 30 - 400 nM with the MGMT unmethylated cell line LN-18 being among the most sensitive. A single cycle of LP-184 (4 mg/kg, i.v, every other day X 4 doses) induced rapid and near complete regression of subcutaneous U87 xenografts pre-established in immune-deficient mice and statistically significantly prolonged survival of mice bearing pre-established orthotopic U87 xenografts (p &amp;lt; 0.0001). LP-184-induced DNA damage is associated with synthetic lethality in tumor cell lines with decreased expression of Nucleotide Excision Repair (NER) genes. Furthermore, interrogation of clinical databases for expression of 112 NER genes revealed that 25 - 37% of clinical GBM clusters in a low NER expression subgroup, predicting high sensitivity of low NER GBM subsets to LP-184. These findings identify LP-184 as a promising new alkylating agent and support its further development for GBM therapy.
Modeling Impact Mechanics of 3D Helicoidally Architected Polymer Composites Enabled by Additive Manufacturing for Lightweight Silicon Photovoltaics Technology (2022)

When silicon solar cells are used in the novel lightweight photovoltaic (PV) modules using a sandwich design with polycarbonate sheets on both the front and back sides of the cells, they are much more prone to impact loading, which may be prevalent in four-season countries during wintertime. Yet, the lightweight PV modules have recently become an increasingly important development, especially for certain segments of the renewable energy markets all over the world-such as exhibition halls, factories, supermarkets, farms, etc.-including in countries with harsh hailstorms during winter. Even in the standard PV module design using glass as the front sheet, the silicon cells inside remain fragile and may be prone to impact loading. This impact loading has been widely known to lead to cracks in the silicon solar cells that over an extended period of time may significantly degrade performance (output power). In our group's previous work, a 3D helicoidally architected fiber-based polymer composite (enabled by an electrospinning-based additive manufacturing methodology) was found to exhibit excellent impact resistance-absorbing much of the energy from the impact load-such that the silicon solar cells encapsulated on both sides by this material breaks only at significantly higher impact load/energy, compared to when a standard, commercial PV encapsulant material was used. In the present study, we aim to use numerical simulation and modeling to enhance our understanding of the stress distribution and evolution during impact loading on such helicoidally arranged fiber-based composite materials, and thus the damage evolution and mechanisms. This could further aid the implementation of the lightweight PV technology for the unique market needs, especially in countries with extreme winter seasons.
Compact low-power coder for extreme bit rate reduction of television pictures (1980)

A subsystem is described which enables real-time television pictures to be transmitted with very low bit rates while preserving spatial and temporal resolutions adequate for scene monitoring. The chief design constraints were to minimise the size and power consumption in an inexpensive robust construction. This was achieved by optimising the frame rate and picture resolution and by removing image redundancy using a variable Walsh transform d.p.c.m. coding scheme. A c.c.d. imager, custom l.s.i. and standard digital componets now enable a compact low-data-rate sensor and data link to be realised effectively.
Fast 3D Wheel Acquisition: Comparison of Efficacy for Cerebral MR Angiography with Conventional Parallel Imaging (2023)

To the best of our knowledges, there are no major papers that assess the influence of Fast 3D wheel to cerebral MR angiography in patients with cerebrovascular diseases. We hypothesize that &amp;ldquo;Fast 3D wheel (Fast 3Dw)&amp;rdquo; has a potential to reduce examination time without degradation of image quality and aneurysm or vascular evaluations, when compared with PI. The purpose of this study was to directly compare the efficacy of Fast 3Dw for cerebral MR angiography with conventional PI in patients with cerebral aneurysm.
Nodal Analysis for SAGD Production Wells with ESPs (2014)

Abstract Steam Assisted Gravity Drainage (SAGD) is an enhanced oil recovery process whereby a long horizontal steam injection well is located above a long horizontal production well. Injected steam forms a steam chamber above the SAGD well pair, heating the reservoir rock and reservoir fluids. Heated oil (or bitumen) plus condensed steam flows down the sides of the steam chamber towards the production well. The condensed steam and bitumen are then lifted to surface with a downhole pump or by gas lift. Over the past decade, SAGD has become an increasingly popular method for extracting bitumen from Canadian oilsand leases that are too deep for surface mining, largely due to the high recovery factor from SAGD. Nodal analysis for oil and gas wells enables the user to model well production or injection performance from the producing reservoir to the surface gathering system. Nodal analysis for well performance is based on the principle that reservoir inflow and wellbore outflow can be independently characterized as functions of flow rate. The single rate that balances the pressure losses in the inflow-outflow components with the pressure drop across the total system defines well flow. Nodal analysis is used to design new wells and optimize production or injection on existing wells. In addition, wellbore simulations are cheaper than instrumentation, meters or single well tests. Well evaluation software is the most popular package in Suncor's conventional production engineering toolkit because it is very accurate and easy to use. Due to a rapidly increasing number of SAGD well pairs, Suncor required a tool that could accurately model these thermal wells. Over the past few years we worked with our software provider to develop nodal analysis for SAGD production wells, and we can now model SAGD producers with electric submersible pumps (ESP) with a high degree of confidence. The new SAGD nodal models quite closely match production rates, plus surface and downhole pressure and temperature data. Reliable and rigorous SAGD nodal models will enable improved decisions with respect to SAGD field development and production optimization.