gebhart/patrepeval huggingface dataset:
CCL2/EGF positive feedback loop between cancer cells and macrophages promotes cell migration and invasion in head and neck squamous cell carcinoma (2016)

Head and neck squamous cell carcinoma (HNSCC) represents the most frequent malignancy in the head and neck region, and the survival rate has not been improved significantly over the past three decades. It has been reported the infiltrated macrophages contribute to the malignant progression of HNSCC. However, the crosstalk between macrophages and cancer cells remains poorly understood. In the present study, we explored interactions between monocytes/macrophages and HNSCC cells by establishing the direct co-culture system, and found that the crosstalk promoted the migration and invasion of cancer cells by enhancing the invadopodia formation through a CCL2/EGF positive feedback loop. Our results demonstrated HNSCC cells educated monocytes into M2-like macrophages by releasing C-C motif chemokine ligand 2 (CCL2, or MCP-1). And the M2-like macrophages secreted epithelial growth factor (EGF), which increased the motility of HNSCC cells by enhancing the invadopodia formation. These subcellular pseudopodia degraded extracellular matrix (ECM), facilitating tumor local invasion and distant metastasis. Moreover, EGF up-regulated CCL2 expression in HNSCC cells, which recruited monocytes and turned them into M2-like macrophages, thus forming a positive feedback paracrine loop. Finally, we reported that curcumin, a powerful natural drug, suppressed the production of EGF and CCL2 in macrophages and cancer cells, respectively, blocking the feedback loop and suppressing the migration and invasion of HNSCC cells. These results shed light on the possibilities and approaches based on targeting the crosstalk between cancer cells and monocytes/macrophages in HNSCC for potential cancer therapy.
Clinical Study of 16 Cases of Secondary Hyperparathyroidism (2005)

Total parathyroidectomy and autotransplantation of parathyroid glands were performed in 9 patients and subtotal parathyroidectomy was performed in 7 patients with secondary hyperparathyroidism resulting from chronic renal failure. The detection rate of enlarged parathyroid glands by preoperative imaging was 38% by computed tomography, 77% by ultrasonography, and 44% by MIBI scintigraphy. The removal rate of parathyroid glands by operation was 89%.In order to remove supernumerary glands, we need to improve operation methods. It is appropriate that the resection of pre- and paratrachial tissues should be performed in addition to the simple parathyroidectomy in cases in which not all parathyroid glands can be found.
Preface:  Relay Feedback in Control Design (2006)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTPreface: Relay Feedback in Control DesignKok Kiong TanView Author Information Department of Electrical and Computer Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore 117576Cite this: Ind. Eng. Chem. Res. 2006, 45, 12, 4019Publication Date (Web):May 31, 2006Publication History Published online31 May 2006Published inissue 1 June 2006https://pubs.acs.org/doi/10.1021/ie068003thttps://doi.org/10.1021/ie068003teditorialACS PublicationsCopyright © 2006 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views309Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (6 KB) Get e-AlertscloseSUBJECTS:Process control,Testing and assessment Get e-Alerts
Photochemistry of 1-Aryl-4-(pentamethyldisilanyl)-1,3-butadiynes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry of 1-Aryl-4-(pentamethyldisilanyl)-1,3-butadiynesJang Hyuk Kwon, Seong Taek Lee, Sang Chul Shim, and Mikio HoshinoCite this: J. Org. Chem. 1994, 59, 5, 1108–1114Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/jo00084a031https://doi.org/10.1021/jo00084a031research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Extrusion-based 3D printing of ex situ-alloyed highly biodegradable MRI-friendly porous iron-manganese scaffolds (2021)

Additively manufactured biodegradable porous iron has been only very recently demonstrated. Two major limitations of such a biomaterial are very low biodegradability and incompatibility with magnetic resonance imaging (MRI). Here, we present a novel biomaterial that resolves both of those limitations. We used extrusion-based 3D printing to fabricate ex situ-alloyed biodegradable iron-manganese scaffolds that are non-ferromagnetic and exhibit enhanced rates of biodegradation. We developed ink formulations containing iron and 25, 30, or 35 wt% manganese powders, and debinding and sintering process to achieve Fe-Mn scaffolds with 69% porosity. The Fe25Mn scaffolds had the ε-martensite and γ-austenite phases, while the Fe30Mn and Fe35Mn scaffolds had only the γ-austenite phase. All iron-manganese alloys exhibited weakly paramagnetic behavior, confirming their potential to be used as MRI-friendly bone substitutes. The in vitro biodegradation rates of the scaffolds were very much enhanced (i.e., 4.0 to 4.6 times higher than that of porous iron), with the Fe35Mn alloy exhibiting the highest rate of biodegradation (i.e., 0.23 mm/y). While the elastic moduli and yield strengths of the scaffolds decreased over 28 days of in vitro biodegradation, those values remained in the range of cancellous bone. The culture of preosteoblasts on the porous iron-manganese scaffolds revealed that cells could develop filopodia on the scaffolds, but their viability was reduced by the effect of biodegradation. Altogether, this research marks a major breakthrough and demonstrates the great prospects of multi-material extrusion-based 3D printing to further address the remaining issues of porous iron-based materials and, eventually, develop ideal bone substitutes. STATEMENT OF SIGNIFICANCE: 3D printed porous iron biomaterials for bone substitution still encounter limitations, such as the slow biodegradation and magnetic resonance imaging incompatibility. Aiming to solve the two fundamental issues of iron, we present ex-situ alloyed porous iron-manganese scaffolds fabricated by means of multi-material extrusion-based 3D printing. Our porous iron-manganese possessed enhanced biodegradability, non-ferromagnetic property, and bone-mimicking mechanical property throughout the in vitro biodegradation period. The results demonstrated a great prospect of multi-material extrusion-based 3D printing to further address the remaining challenges of porous iron-based biomaterials to be an ideal biodegradable bone substitutes.
Micromirror device controlled tunable diode laser (2007)

An electronically controlled external cavity laser diode for fast wavelength tuning and multiple-colour lasing is presented. The spectral-tuning is accomplished by a digital micromirror device. Tuning of 47.4 nm with a tuning speed of 0.85 nm/ms was achieved. Simultaneous emission of up to 9 laser lines is demonstrated.
Signaling Reduction in Idle Mode for Inter-Technology Mobility (2007)

With the proliferation of air interface technologies, there are increasingly multi-mode user equipment devices (UEs) that can operate in more than one technology, although not at the same time. To save battery life, the UEs will camp in only one technology at any point in time even when there is coverage of multiple technologies. One key requirement is to limit the uplink signaling when UEs capable of operating in multiple radio access technologies perform inter-technology handovers in idle mode. In this paper, we propose a scheme that reduces this signaling by sending an inter-technology update to the network only when the UE loses coverage of the previously used technology. We also analyze the performance benefits of this scheme with that of the approach of camping on the preferred technology whenever coverage of that technology is available.
A novel transcription factor is correlated with both glomerular proliferation and sclerosis in the rat renal ablation model (1997)

Glomerular accumulation of the extracellular matrix (ECM) with subsequent sclerosis is a common finding in most progressive renal diseases. Recently MSW (Mouse South Western) protein was cloned by its ability to bind the bidirectional promoter of the collagen IV genes. This protein was also reported as the large subunit of the DNA replication complex A1, as well as the promoter binding protein of corticotropin-releasing hormone and the angiotensinogen gene. To investigate the mechanism of accumulation of the ECM as it relates to glomerular cellular events, the expression of MSW protein was studied in the remnant kidney model. Progressive expression of MSW protein was found in the glomerular sclerotic lesion at week 4 and at later time points after renal ablation. The expression of proliferating cell nuclear antigen (PCNA) and type IV collagen was also correlated with the expression of MSW protein by immunofluorescence. RNA dot blot analysis also showed that the expression of MSW mRNA was increased at week 7 in association with the augmented expression of type IV collagen. These results, taken together, suggest that MSW protein plays an important role in the regulation of type IV collagen gene expression in vivo and may contribute to glomerular cell proliferation and the development of glomerulosclerosis.© 1997 by John Wiley & Sons, Ltd.
The Smart Acquisition And Analysis Module (SAAM) For Pipeline Inspection (2000)

This paper describes a low-cost pipeline inspection tool developed by RST Projects, Scotland. The methodology underpinning the operation of the tool is fundamentally different ffi'om conventional in-line inspection systems. This emphasis of the present paper is placed on the basis for this approach and an explanation of the advantages in comparison with conventional intelligent pigging methods. A discussion of the necessary technical innovations is given. A brief example, from an offshore pipeline survey, showing how spool pieces can be identified by detection of the weld signature is presented. With the current volatility in the hydrocarbon market it is believed that this lower-cost approach will offer considerable advantage particularly where pipelines are working with low profit margins or in extending the life of older lines.
Quantitative assessment of MRI lesion load in monitoring the evolution of multiple sclerosis (1995)

In recent years, several segmentation techniques have been developed to quantify brain MRI lesion load in multiple sclerosis and are now being used increasingly for both evaluating the natural history of the disease and monitoring the efficacy of treatment. Such techniques have been applied extensively to conventional T2-weighted images; there is less experience to date with gadolinium-enhanced scans and newer MR parameters which are thought to reflect the more destructive aspects of the pathological process. Manual outlining of lesions on T2-weighted images is moderately accurate when performed by an experienced observer and has been validated in large clinical trials, but is very time consuming. Semi-automated intensity-based techniques appear to be more reproducible, but are still slow to perform. Faster techniques with higher reproducibility are still needed. The correlations between conventional T2 lesion load and clinical outcome is strong in patients seen at first presentation with clinically isolated syndromes suggestive of multiple sclerosis, but much weaker in established multiple sclerosis. The application of quantitative assessment of the MR parameters which are more specific for the disabling aspects of the pathological process (i.e. demyelination, axonal loss and spinal cord involvement) may improve the correlation with clinical status.
SeaTrack: Ground station orbit prediction and planning software for sea-viewing satellites (1993)

An orbit prediction software package (Sea Track) was designed to assist High Resolution Picture Transmission (HRPT) stations in the acquisition of direct broadcast data from sea-viewing spacecraft. Such spacecraft will be common in the near future, with the launch of the Sea viewing Wide Field-of-view Sensor (SeaWiFS) in 1994, along with the continued Advanced Very High Resolution Radiometer (AVHRR) series on NOAA platforms. The Brouwer-Lyddane model was chosen for orbit prediction because it meets the needs of HRPT tracking accuracies, provided orbital elements can be obtained frequently (up to within 1 week). Sea Track requires elements from the U.S. Space Command (NORAD Two-Line Elements) for the satellite's initial position. Updated Two-Line Elements are routinely available from many electronic sources (some are listed in the Appendix). Sea Track is a menu-driven program that allows users to alter input and output formats. The propagation period is entered by a start date and end date with times in either Greenwich Mean Time (GMT) or local time. Antenna pointing information is provided in tabular form and includes azimuth/elevation pointing angles, sub-satellite longitude/latitude, acquisition of signal (AOS), loss of signal (LOS), pass orbit number, and other pertinent pointing information. One version of Sea Track (non-graphical) allows operation under DOS (for IBM-compatible personal computers) and UNIX (for Sun and Silicon Graphics workstations). A second, graphical, version displays orbit tracks, and azimuth-elevation for IBM-compatible PC's, but requires a VGA card and Microsoft FORTRAN.
Comments on barrier changes in stressed metal-semiconductor contacts (1974)

Considerable attention has been given to stress effects in M-S contacts. This interest arises out of problems of device technology and out of interest in possible sensor development. This work examines the effects of stress analytically. In particular, barrier height changes with stress are studied and a discussion is presented correlating predicted changes with experimental data. Recent interesting conclusions regarding the shift of surface states and the electron affinity of silicon with stress are examined.
Ultrasound of the sentinel node in melanoma patients: echo-free island is a discriminatory morphologic feature for node positivity (2016)

Unlike breast and thyroid cancer, the use of ultrasound (US)-guided fine needle aspiration cytology (FNAC) for preoperative staging is limited in melanoma. New US morphology criteria have shown that US-FNAC can correctly identify 50% of all involved sentinel nodes (SN) in melanoma patients before surgical excision. The aim of this study was to examine a new criterion: the echo-free island (EFI). A total of 1000 consecutively staged melanoma patients (Breslow thickness>1 or<1 mm, but ulcerated, Clark IV/V or regressed) scheduled for SN staging underwent preoperative US. US morphology items were assessed: peripheral perfusion, loss of central echoes, balloon shape, and EFI. FNAC was performed in case of suspicious and malignant US patterns. All patients proceeded to undergo an SN biopsy or direct completion lymph node dissection (CLND) (in the case of positive FNAC). In all, 57% of the patients were men. The mean/median Breslow thickness was 2.58/1.57 mm. The mean/median follow-up was 56/53 months. SN was positive in 21%. EFI information was available in 95.3%. EFI was seen in 40 patients (4%). EFI sensitivity was 10.8%, specificity was 97.6%, positive predictive value was 50%, and negative predictive value was 80.2%. EFI was significantly correlated to peripheral perfusion (67.5%). There was no correlation to balloon shape or loss of central echoes. Five-year melanoma-specific survival of patients with EFI was significantly worse: 80% versus 92% when absent. The EFI can be useful in the early detection of SN melanoma metastasis. It is an early sign of involvement and thus associated with a decreased survival.
Frequencies and Thermal Stability of Isolated Surface Hydroxyls on Pyrogenic TiO2 Nanoparticles (2019)

The surface reactivity of TiO2 is often governed by hydroxyl groups. Fourier transform infrared (FTIR) spectroscopy is the most commonly used method to study surface hydroxyls. However, interpretation of the observed bands of powder samples is not straightforward. In this work, we propose a facet-specific assignment of the surface hydroxyls of pyrogenic TiO2 (commonly known as P25 and P90) by comparison between experimentally observed FTIR bands of P90, rutile, and anatase with calculated vibrational frequencies for well-defined surface facets using density functional theory. Titania was calcined for extended periods in extremely dry O2 to remove carbonates and water for diffuse reflectance infrared spectroscopy measurements of the most thermally stable hydroxyls remaining in the 300–400 °C range. Reactions of the dehydroxylated surfaces with H2(D2) provided further insight into hydroxyl formation. Theoretical assignments of hydroxyls were based on the calculated thermal stability of hydroxyls to dehydroxylation, agreement with calculated frequencies [scaled to be consistent with the experimental bridging hydroxyl frequency on rutile TiO2(110)], and the thermodynamic stability of the specific facets. Our assignments, combined with previous results, show that terminal and bridging hydroxyl frequencies overlap; therefore, the common assumption that terminal hydroxyls vibrate at higher frequencies is not valid.
Remyelination of Demyelinated CNS Axons by Transplanted Human Schwann Cells: The Deleterious Effect of Contaminating Fibroblasts (2001)

Areas of demyelination can be remyelinated by transplanting myelin-forming cells. Schwann cells are the naturally remyelinating cells of the peripheral nervous system and have a number of features that may make them attractive for cell implantation therapies in multiple sclerosis, in which spontaneous but limited Schwann cell remyelination has been well documented. Schwann cells can be expanded in vitro, potentially affording the opportunity of autologous transplantation; and they might also be spared the demyelinating process in multiple sclerosis. Although rat, cat, and monkey Schwann cells have been transplanted into rodent demyelinating lesions, the behavior of transplanted human Schwann cells has not been evaluated. In this study we examined the consequences of injecting human Schwann cells into areas of acute demyelination in the spinal cords of adult rats. We found that transplants containing significant fibroblast contamination resulted in deposition of large amounts of collagen and extensive axonal degeneration. However, Schwann cell preparations that had been purified by positive immunoselection using antibodies to human low-affinity nerve growth factor receptor containing less than 10% fibroblasts were associated with remyelination. This result indicates that fibroblast contamination of human Schwann cells represents a greater problem than would have been appreciated from previous studies.
Evaluation of IMRT QA Point Measurement Rocesses Using a Commercial Heterogeneous Phantom (2010)

Intensity Modulated Radiation Therapy (IMRT) has the potential to deliver a highly conformal dose distribution to the target volume compared to conventional radiotherapy. However, the use of IMRT introduces complexities in dose delivery and veri fi cation. Routine IMRT QA is typically performed in a homogeneous solid water phantom and does not verify the accuracy of a treatment planning system’s handling of the heterogeneity correction algorithm, which is particularly important in a low density lung medium. The purpose of this work is to evaluate common IMRT QA point measurement processes that take advantage of a commercial heterogeneous phantom [CIRS IMRT thorax phantom (CIRS, Inc., Norfolk, Virginia, USA)]. Dose calculated with Monte Carlo (MC) methods and pencil beam (PB) methods are used. IMRT QA using the CIRS phantom with the MC and PB algorithms was retrospectively analyzed using control charts and a capability index. Fifteen actual IMRT treatment plans of lung cancer patients were used for this study. The dose was measured in the phantom at points located in lung, bone, and tissue with an ion chamber (IC) for 15 cases and thermoluminescent dosimeters (TLDs) for 5 cases. Measurements and calculations in each heterogeneity (e.g., TLD/MC in bone) were considered as separate processes. Control charts and the capability index Cpm were used to evaluate the following processes using the CIRS phantom: IC/MC, PB/MC, TLD/MC for measurements in the lung, tissue and bone. The processes PB/IC and MC/IC using conventional homogeneous water-equivalent slab geometry were also evaluated. In total, 11 IMRT QA processes were considered. Comparison of the data showed that the dose inside the lung calculated with PB was overestimated by 6% on average relative to the MC calculations. On average, MC calculations in bone and tissue agree within 3% with PB calculations and IC measurements. Process capability values (Cpm) greater than 1.33 indicate a well performing process. Using the CIRS phantom, Cpm ranged from 0.25 for the PB/ MC process in lung to 1.41 for the TLD/MC process in tissue. By comparison, the process using the conventional water- equivalent slab phantom showed the PB/IC and MC/IC Cpm values of 1.36 and 1.21, respectively. Nine of the 11 IMRT QA processes studied were not able to meet the clinical speci fi cations of 5%. However, we found the CIRS phantom is versatile to compare both homogeneous and heterogeneous IMRT QA measurements to calculations. Our results indicate that additional re fi nements of the IMRT QA processes are required. This is especially true for calculations and measurements in lung-equivalent media. The capability index is a simple and useful quantitative tool for comparing different approaches to lung IMRT QA.