gebhart/patrepeval huggingface dataset:
Spatial and temporal development of deltamethrin resistance in malaria vectors of the Anopheles gambiae complex from North Cameroon (2019)

The effectiveness of insecticide-based malaria vector control interventions in Africa is threatened by the spread and intensification of pyrethroid resistance in targeted mosquito populations. The present study aimed at investigating the temporal and spatial dynamics of deltamethrin resistance in An. gambiae s.l. populations from North Cameroon. Mosquito larvae were collected from 24 settings of the Garoua, Pitoa and Mayo Oulo Health Districts (HDs) from 2011 to 2015. Two to five days old female An. gambiae s.l. emerging from larval collections were tested for deltamethrin resistance using the World Health Organization's (WHO) standard protocol. Sub samples of test mosquitoes were identified to species using PCR-RFLP and genotyped for knockdown resistance alleles (Kdr 1014F and 1014S) using Hot Ligation Oligonucleotide Assay (HOLA). All the tested mosquitoes were identified as belonging to the An. gambiae complex, including 3 sibling species mostly represented by Anopheles arabiensis (67.6%), followed by Anopheles coluzzii (25.4%) and Anopheles gambiae (7%). Deltamethrin resistance frequencies increased significantly between 2011 and 2015, with mosquito mortality rates declining from 70-85% to 49-73% in the three HDs (Jonckheere-Terstra test statistic (JT) = 5638, P< 0.001), although a temporary increase of mortality rates (91-97%) was seen in the Pitoa and Mayo Oulo HDs in 2012. Overall, confirmed resistance emerged in 10 An. gambiae s.l. populations over the 24 field populations monitored during the study period, from 2011 to 2015. Phenotypic resistance was mostly found in urban settings compared with semi-urban and rural settings (JT = 5282, P< 0.0001), with a spatial autocorrelation between neighboring localities. The Kdr 1014F allelic frequencies in study HDs increased from 0-30% in 2011 to 18-61% in 2014-2015 (JT = 620, P <0.001), especially in An. coluzzii samples. The overall frequency of the Kdr 1014S allele was 0.1%. This study revealed a rapid increase and widespread deltamethrin resistance frequency as well as Kdr 1014F allelic frequencies in An. gambiae s.l. populations over time, emphasizing the urgent need for vector surveillance and insecticide resistance management strategies in Cameroon.
Continuous computer-assisted electrocardiographic monitoring in patients with acute myocardial infarction: early experience (2003)

Results of 3311 h of continuous digital 12-lead ST segment monitoring in a pilot population of 77 patients treated early in myocardial infarction (MI) with thrombolytic therapy are reported. 'Mean beat' signal processing over 353 min of monitoring in 12 patients subjected to normal flight vibration during helicopter transport was compared with 390 min of monitoring in 12 patients in the coronary care unit (CCU). Automated ST episode detection triggered 15 episodes in helicopter and 19 episodes in CCU, of which 3/15 (20%) and 7/19 (37%) were artifact, respectively. From the 77 patients overall, ST trend evidence of changes in infarct vessel patency was noted more than twice in 38 (49%), more than four times in 21 (27%), and more than six times in 11 (14%). ST evidence of patency change occurred from 30 s to 47.6 h apart. It is concluded that mean beat signal processing can provide technically adequate ECG monitoring information even with a vibrating signal source during helicopter transport and that continuous ST monitoring may be useful for detecting changes in infarct vessel patency occurring outside the brief time window of acute angiography.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Stability of Oxide TFTs under Electrical Gate Bias and Monochromatic Light Illumination (2010)

We have investigated a stability of oxide TFTs (IGZO) under electrical bias and monochromatic light illumination. Under -20 V gate bias, when 650 nm monochromatic illumination with intensity of 1 mW/cm2 was radiated, threshold voltage (Vth) was shifted by about -1.55 V while Vth was almost constant without illumination. Even though the photon energy of 650 nm is much smaller than optical band gap of oxide active layer (Eopt~3.0 eV), Vth was changed due to generation of carriers through localized state. However, under positive gate bias of 20 V, Vth was not changed with and without 650 nm light illumination. In terms of 300 nm wavelength light, Vth was shifted positively under negative bias stress and negatively under positive bias stress. It is considered that light affected not only the active layer but also the gate insulator layer.
Flight simulation fatigue tests on lugs with holes expanded according to the split-sleeve cold work method (1978)

Flight simulation tests on 2024-T3 and 7075-T6 lug specimens indicated significant fatigue life improvements obtained by expanding the holes in accordance with the split-sleeve cold work method. Geometrical distortions induced by the expansion were measured. The significance of residual stresses is analysed with reference to depth of penetration of cold work, to relaxation of residual stress by cyclic loads and to some other practical aspects.
Dual-Comb spectroscopy for GHG quantification (2016)

Near-infrared frequency-comb spectroscopy is a powerful tool with which to measure concentrations of gasses relevant to combustion and atmospheric monitoring (CO2, CH4, H2O, HDO) over meter and kilometer scale paths.
Synthesis of Tubercidin, 6-Chlorotubercidin and Related Nucleosides (1989)

Abstract Tubercidin (7-deazaadenosine, 1a) and several 6-chlorotuber-cidin derivatives were synthesized including 4-amino-6-chloro-7-β-D-ribofuranosylpyrrolo[2,3-d]pyrimidine-3′,5′-cycyclic phosphate 9. Isolation of a side product found in the glycosylation step of the reaction sequence proved to be the N-1 ribosyl-attached isomer as shown by X-ray diffraction analysis. All derivatives were tested for in vitro antiviral and antitumor activity.
Doping dependence of the Raman peaks intensity of graphene close to the Dirac point (2009)

Here we use pristine graphene samples in order to analyze how the Raman peaks intensity, measured at 2.41 and 1.96 eV excitation energy, changes with the amount of doping. The use of pristine graphene allows investigating the intensity dependence close to the Dirac point. We show that the $G$ peak intensity is independent on the doping, while the 2D peak intensity strongly decreases for increasing doping. Analyzing this dependence in the framework of a fully resonant process, we found that the total electron-phonon scattering rate is $\ensuremath{\sim}40\text{ }\text{meV}$ (60 ${\text{ps}}^{\ensuremath{-}1}$) at 2.41 eV.
ChemInform Abstract: A Facile Preparation of 3‐Substituted 2‐Thioxotetrahydroquinazolin‐4‐ones by the Reaction of Anthranilamide with Isothiocyanates. (1988)

Abstract Anthranilamide (II) undergoes ring closure with the isothiocyanates (Ia) to give the 2‐(thioxo)tetrahydroquinazolin‐4‐ones (IIIa).
Performance of Gifted and Talented Subjects on the Woodcock-Johnson Tests of Cognitive Ability and the WISC-R (1984)

This study compared the performance of a sample of 46 gifted and talented students on the Woodcock-Johnson Tests of Cognitive Ability and the Wechsler Intelligence Scale for Children-Revised. The difference between full scale scores was not significant, suggesting concurrent validity between the two full scale measures. Scores obtained on the Reasoning cluster were suspect for some of the gifted and talented subjects, with the altemative cluster of Broad Reasoning providing a more acappraisal of ability.
Modeling of power diodes with the lumped-charge modeling technique (1997)

The lumped-charge modeling technique is used to build a simple, physics-based power diode model for circuit simulators. The model consists of simplified, but fundamental semiconductor device equations. The important characteristics of power diodes under static and dynamic conditions are obtained in this compact and efficient model.
Mechanism of Inhibition for BMS-791325, a Novel Non-nucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase (2014)

HCV infection is an urgent global health problem that has triggered a drive to discover therapies that specifically target the virus. BMS-791325 is a novel direct antiviral agent specifically targeting HCV NS5B, an RNA-dependent RNA polymerase. Robust viral clearance of HCV was observed in infected patients treated with BMS-791325 in combination with other anti-HCV agents in Phase 2 clinical studies. Biochemical and biophysical studies revealed that BMS-791325 is a time-dependent, non-competitive inhibitor of the polymerase. Binding studies with NS5B genetic variants (WT, L30S, and P495L) exposed a two-step, slow binding mechanism, but details of the binding mechanism differed for each of the polymerase variants. For the clinically relevant resistance variant (P495L), the rate of initial complex formation and dissociation is similar to WT, but the kinetics of the second step is significantly faster, showing that this variant impacts the final tight complex. The resulting shortened residence time translates into the observed decrease in inhibitor potency. The L30S variant has a significantly different profile. The rate of initial complex formation and dissociation is 7-10 times faster for the L30S variant compared with WT; however, the forward and reverse rates to form the final complex are not significantly different. The impact of the L30S variant on the inhibition profile and binding kinetics of BMS-791325 provides experimental evidence for the dynamic interaction of fingers and thumb domains in an environment that supports the formation of active replication complexes and the initiation of RNA synthesis.
Impact of Birth and Body Weight at Twenty Days on thePostweaning Growth of Pigs with Different Weaning Management (2007)

Pigs from 112 litters were assigned to 3 different treatments and their BW growth to 125 kg was determined. The 3 treatments were as follows: sow-reared, weaning at 14 d of age, and weaning at 2 d of age. Piglets from litters weaned at 14 d of age were fed a milk replacer after weaning until the day the sowreared litters were weaned. Piglets from litters weaned 2 d after birth were fed the milk replacer for 19 d after weaning. Pigs were individually weighed at birth at about 20 d of age, at 32 kg BW, and every 2 wk thereafter. The grow-finish BW data were fitted to a generalized Michaelis-Menten equation. The relationships of 20-d BW to birth BW were different for each treatment. Postweaning BW and days to attain 125 kg had nonlinear relationships with birth and 20-d BW. A 0.1 kg increase in birth BW reduced predicted days to reach 125 kg BW by 3.48, 0.92, and 0.18 d at 1.0, 1.5, and 2.0 kg birth BW, respectively. A 0.1 kg increase in 20-d BW decreased predicted days to reach 125 kg by 0.57, 0.38, and 0.26 d at 5.0, 6.5, and 8.0 kg 20-d BW, respectively. Increasing the BW of the lightest birth BW and 20-d BW pigs had a greater impact on subsequent BW than increasing the BW of pigs with average to above average birth and 20-d BW.
Voluntary wheel running activates Akt/AMPK/eNOS signaling cascades without improving profound endothelial dysfunction in mice deficient in α-galactosidase A (2019)

Fabry disease is caused by loss of activity of the lysosomal hydrolase α-galactosidase A (GLA). Premature life-threatening complications in Fabry patients arise from cardiovascular disease, including stroke and myocardial infarction. Exercise training has been shown to improve endothelial dysfunction in various settings including coronary artery disease. However, the effects of exercise training on endothelial dysfunction in Fabry disease have not been investigated. Gla knockout mice were single-housed in a cage equipped with a voluntary wheel (EX) or no wheel (SED) for 12 weeks. Exercised mice ran 10 km/day on average during the voluntary running intervention (VR) period. Despite significantly higher food intake in EX than SED, body weights of EX and SED remained stable during the VR period. After the completion of VR, citrate synthase activity in gastrocnemius muscle was significantly higher in EX than SED. VR resulted in greater phosphorylation of Akt (S473) and AMPK (T172) in the aorta of EX compared to SED measured by western blot. Furthermore, VR significantly enhanced eNOS protein expression and phosphorylation at S1177 by 20% and 50% in the aorta of EX when compared with SED. Similarly, plasma nitrate and nitrite levels were 77% higher in EX than SED. In contrast, measures of anti- and pro-oxidative enzymes (superoxide dismutase and p67phox subunit of NADPH oxidase) and overall oxidative stress (plasma oxidized glutathione) were not different between groups. Although the aortic endothelial relaxation to acetylcholine was slightly increased in EX, it did not reach statistical significance. This study provides the first evidence that VR improves Akt/AMPK/eNOS signaling cascades, but not endothelial function in the aorta of aged Gla deficient mice.
Automatic eyebrow features detection and realization of avatar for real time eyebrow movement (2012)

This paper focuses on extraction of eyebrow key points in video sequences and realization of an avatar that uses the located key point's coordinates to show automatic movements of eyebrow in accordance with the video clip. The work uses a color based method for automatic segmentation of eyebrows from video clips and extraction of the key eyebrow features like, two corners of the eyebrows and upper and lower mid points, from eyebrow contour. The color based method of eyebrow segmentation extracts pseudo-hue plane of eyebrow region to separates eyebrow from skin region. The second part of the work focuses on the realization of avatar for eyebrow movements using the obtained eyebrow features. The eyebrow segmentation and features extraction method is much faster than other existing model based methods, as it is simple and uses no prior information about the eyebrow, also it needs no learning method. Around 200 frontal face images from FEI face database [1] and around 100 facial expression videos containing nearly frontal face images from MMI database [2] are tested. Accurate eyebrow segmented region key point detection result is obtained. Finally an avatar is realized which shows the automatic eyebrow movements in accordance to that of the video clip.
Vigilancia epidemiológica prospectiva de la enfermedad neumocócica invasora y de la neumonía en niños de San José, Costa Rica (2012)

"Justificación y objetivo: Streptococcus pneumoniae es globalmente la primera causa de muertes inmunoprevenibles en niños menores de 5 años. Métodos: entre 2007 y 2009 se realizó una vigilancia prospectiva con base poblacional en niños de 28 días a 36 meses en San José, Costa Rica. Se determinaron la incidencia de la enfermedad neumocócica invasora y de neumonía confirmada clínicamente y por radiografía, la distribución de serotipos y la sensibilidad a los antibióticos. Resultados: participaron 8801 sujetos (mediana de edad: 13,0 meses). En 25 niños se detectó enfermedad neumocócica invasora mediante aislamiento en cultivos (22) o mediante reacción de polimerasa en cadena y un cuadro clínico compatible con enfermedad neumocócica invasora (3) En los casos diagnosticados únicamente por cultivo, la tasa de incidencia de enfermedad neumocócica invasora en niños de 28 días a 36 meses de edad fue de 33,7/100 000 por año para los años 1 y 2 combinados. Al considerar los casos adicionales diagnosticados por reacción de polimerasa en cadena, la incidencia aumentó a 46,0/100 000. El serotipo más frecuente fue el 14 (28,6%), seguido por los serotipos 3, 4, 6A, 19A y 22F. 42,9% de los aislamientos eran insensibles a la penicilina y al cotrimoxazol. La incidencia de neumonía confirmada clínicamente y de neumonía confirmada por radiografía fue de 1968/100 000 y 551/100 000, respectivamente. Conclusión: la incidencia de enfermedad neumocócica invasora y neumonía en niños de San José es considerable. Estos datos epidemiológicos sirven como línea de base para evaluar la efectividad de nuevas vacunas antineumocócicas conjugadas."
HIV Control Is Mediated in Part by CD8 + T-Cell Targeting of Specific Epitopes (2014)

Some individuals naturally control HIV replication in the absence of antiretroviral therapy, and this ability to control is strongly correlated with the HLA class I alleles that they express. Here, in a large-scale experimental study, we provide evidence that this correlation is mediated largely by the targeting of specific CD8(+) T-cell epitopes, and we identify eight epitopes that are likely to cause control. In addition, we provide an in silico analysis indicating that control occurs because mutations within these epitopes change the stability of the protein structures. This in silico analysis also identified additional epitopes that are not typically targeted in natural infection but may lead to control when included in a vaccine, provided that other epitopes that would otherwise distract the immune system from targeting them are excluded from the vaccine.
Unbiased analysis of neutron and X-ray reflectivity data by an evolution strategy (2002)

A new method for the unbiased determination of scattering length density (SLD) profiles from neutron or X-ray reflectograms is presented, based on an evolution strategy. In contrast to existing methods, the new approach uses no constraints that could influence the fit result improperly. While it is widely agreed that SLD profile oscillations with small wavelength and small amplitude cannot be resolved, randomly occurring long-wavelength oscillations have been neglected to date despite the fact that such oscillations can tremendously affect the calculated SLD profile. No easy remedy exists for this problem within the framework of conventional reflectogram analysis methods. The analytical approach proposed in this work offers a solution based on the recognition that each perturbation which leads to an indistinguishable reflectivity has a negative pendant. Averaging of numerous different, randomly perturbed, profiles therefore cancels out random deviations and accentuates reliable features. Moreover, the resulting averaged free-form fit has maximum (information) entropy. The performance of the novel approach is demonstrated by analysing complex molecular arrangements at an air–water interface and comparing the results with prior evaluations.
Fleas and lice parasitizing mammals in Missouri. (1997)

Three species of chewing lice, 11 species of sucking lice, and 28 species of fleas are recorded from mammals in Missouri. Of these, seven species of sucking lice (Hoplopleura acanthopus, Hoplopleura hesperomydis, Hoplopleura sciuricola, Neohaematopinus sciuri, Neohaematopinus sciurinus, Neohaematopinus sciuropteri, and Solenopotes ferrisi) and one species of flea (Doratopsylla blarinae) represent new state records. From 1993 to 1995, 773 individual mammals were examined for ectoparasites in southeastern Missouri. One species of chewing louse, 6 species of sucking lice, and 11 species of fleas were recovered from 18 of the 21 mammal species examined. Ctenophthalmus pseudagyrtes was recovered from more mammal species (6) than any other flea species; and the white-footed mouse, Peromyscus leucopus, was parasitized by more flea species (5) than other hosts examined. Except for H. sciuricola, which was recovered from two congeneric species of tree squirrels, each species of louse was confined to a separate host species.
Adaptive Optics (2000)

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EXPERIMENTAL CLOSED CHEST TRAUMA (1969)

Department of Surgery, State University of New York, and E. J. Meyer Memorial Hospital, Buffalo, New York
Radiologic differential diagnosis. Radiologic pattern: solitary cavity. (1976)

The differential diagnosis of a left lower lobe cavity in this young patient with a history of productive cough should include hiatal hernia, pulmonary abscess, bronchiectatic cyst and bronchopulmonary sequestration. Hiatal hernia should be ruled out by barium swallow; acute pulmonary abscess by the lack of a history suggestive of a necrotizing pneumonia; bronchiectasis by bronchogram; and intralobar bronchopulmonary sequestration should be confirmed by aortography.
Label-free Bio-aerosol Sensing Using On-Chip Holographic Microscopy and Deep Learning (2019)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Y. Wu, A. Calis, Y. Luo, C. Chen, M. Lutton, Y. Rivenson, X. Lin, H. C. Koydemir, Y. Zhang, H. Wang, Z. Göröcs, and A. Ozcan, "Label-free Bio-aerosol Sensing Using On-Chip Holographic Microscopy and Deep Learning," in Conference on Lasers and Electro-Optics, OSA Technical Digest (Optica Publishing Group, 2019), paper AM2K.3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
SXPath (2010)

Querying data from presentation formats like HTML, for purposes such as information extraction, requires the consideration of tree structures as well as the consideration of spatial relationships between laid out elements. The underlying rationale is that frequently the rendering of tree structures is very involved and undergoing more frequent updates than the resulting layout structure. Therefore, in this paper, we present Spatial XPath (SXPath), an extension of XPath 1.0 that allows for inclusion of spatial navigation primitives into the language resulting in conceptually simpler queries on Web documents. The SXPath language is based on a combination of a spatial algebra with formal descriptions of XPath navigation, and maintains polynomial time combined complexity. Practical experiments demonstrate the usability of SXPath.
Automatic probe tuning and matching (1998)

The problem of automatically tuning and matching a probe is considered, and attention is drawn to the main cause of difficulty: the interaction of tuning and matching mechanisms. The use of a doubly resonant, inductively coupled probe is therefore advocated, for to first order, tuning, and matching are then orthogonal for small perturbations. It is shown that when such a probe is equipped with negative feedback control of tuning and matching elements, driven by error signals derived from a bridge and the NMR spectrometer, stable and rapid automatic tuning and matching are achieved. The importance of approximately correct phasing of the error signals is emphasized, but the restriction of having to have specific cable lengths to achieve this task is removed. The effects of small errors of phasing are then considered and shown to be unimportant for the chosen probe, in contrast to the situation for other, nonorthogonal probe types. Suggestions for orthogonalization of two common capacitively coupled probe designs are made, and a practical instrument design is then given that, with the addition of external components, can also be used if the NMR receiver cannot be pressed into service.