gebhart/patrepeval huggingface dataset:
Towards Active-Passive Co-synthesis of Multi-gigaHertz Radio Frequency Circuits (2010)

This paper proposes a methodology and framework for rapid active-passive co-synthesis of radio frequency circuits. The presented approach leverages advances in accelerated three-dimensional electromagnetic simulation technology to construct Maxwell-accurate parametric macromodels of on-chip passives, in particular spiral inductors. These macromodels can be used in the context of SPICE-level synthesis, thereby enabling concurrent sizing of passive and active components of radio frequency circuits. Moreover, macromodels obviate the need for topology exploration and parametric RLC model generation via optimization for on-chip passives. The co-synthesis framework is enabled by nonlinear, hyper-dimensional regression for macromodel generation and a simulated annealing based optimization scheme. As examples, and to demonstrate the efficacy of the proposed approach, two standard low-noise amplifier topologies are synthesized with tight performance constraints by co-optimization of circuit parameters and inductor geometries.
Expression of survivin protein in human colorectal carcinogenesis (2003)

The expression of survivin is the essential event in the early stage of colorectal carcinogenesis and plays an important role in the transition sequence and it is not related to histological differentiation grade of colorectal carcinoma. It thus may provide a new diagnostic and therapeutic target in colorectal cancer.
Seeing Beyond Luminance: A Psychophysical Comparison of Techniques for Converting Colour Images to Greyscale (2007)

Colours are usually described using three perceptual variables: an achromatic variable, such as lightness or luminance, and two &#x201C;chromatic&#x201D; varibles, such as chroma and hue. This means that the conversion of colour images to greyscale is often thought of as the removal of &#x201C;chromatic information&#x201D;, which leaves a greyscale made by just the achromatic colour variable; i.e. luminance or lightness. One obvious problem with this approach is how to make a greyscale for equiluminant images, or images containing equiluminant object boundaries.In this paper we review some of the more recent attempts to tackle the colour-to-greyscale problem. We then use an image preference experiment to test the performance of these methods on a selected set of images; some of which lose a significant amount of information when converted to greyscale using luminance, and others which do not. The results show that, in general, the newer techniques can provide a greyscale image which is preferred to that derived by luminance, especially for images that have prominent equiluminant boundaries. The results also show that this advantage is not guaranteed for every image, and that no particular algorithm provides consistently better performance than the others.
Fact Discovery from Knowledge Base via Facet Decomposition (2019)

Zihao Fu, Yankai Lin, Zhiyuan Liu, Wai Lam. Proceedings of the 2019 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Volume 1 (Long and Short Papers). 2019.
Distribution of mutations in the PEX gene in families with X-linked hypophosphataemic rickets (HYP) (1997)

Mutations in the PEX gene at Xp22.1 (phosphate-regulating gene with homologies to endopeptidases, on the X-chromosome), are responsible for X-linked hypophosphataemic rickets (HYP). Homology of PEX to the M13 family of Zn2+ metallopeptidases which include neprilysin (NEP) as prototype, has raised important questions regarding PEX function at the molecular level. The aim of this study was to analyse 99 HYP families for PEX gene mutations, and to correlate predicted changes in the protein structure with Zn2+ metallopeptidase gene function. Primers flanking 22 characterised exons were used to amplify DNA by PCR, and SSCP was then used to screen for mutations. Deletions, insertions, nonsense mutations, stop codons and splice mutations occurred in 83% of families screened for in all 22 exons, and 51% of a separate set of families screened in 17 PEX gene exons. Missense mutations in four regions of the gene were informative regarding function, with one mutation in the Zn2+-binding site predicted to alter substrate enzyme interaction and catalysis. Computer analysis of the remaining mutations predicted changes in secondary structure, N-glycosylation, protein phosphorylation and catalytic site molecular structure. The wide range of mutations that align with regions required for protease activity in NEP suggests that PEX also functions as a protease, and may act by processing factor(s) involved in bone mineral metabolism.
Cell activity analysis by capillary zone electrophoresis combined with specific cell staining (2010)

Capillary zone electrophoresis (CZE) was used to determine Hela cells activity with Hela treated by 0-46 μM methylmercury (MeHg) as the apoptosis model. The treated and untreated cells were stained by four different dyes (Janus Green B, Rhodamine 123, Neutral Red and Trypan Blue) and analyzed by CZE with UV/Vis detection. The absorbance of cells at 214 nm could indicate the degree of cell shrinkage and component leakage induced by MeHg. The intensity of cell absorbance at maximum visible absorption wavelength of dyes represented mitochondrial activity, lysosome phagocytosis ability and cell membrane integrity. For different concentrations of MeHg treatment, the change of cell activity was in good agreement with Janus Green B uptake colorimetric assay (R² =0.914) and 3-(4, 5-dimethylthiazol-2-yl)-2, 5-di-phenyltetrazolium bromide (MTT) assay (R² =0.892). 80% of RSD (n=3) values were in the range of 0.5-15.0%. The established CZE method could be used to analyze intact cells with only UV-Vis detector. The CZE method has some features equivalent to the existing universal method, and it has the potential to be a universal tool for cell activity determination.
Identification of <i>W09D10.4/PPTC7</i> as a novel AMPK-associated healthspan modulatory factor by using <i>C. elegans </i>Healthspan Auto-monitoring System (C-HAS) (2022)

Caenorhabditis elegans is an experimental organism widely used for longevity studies.
Asymmetrische Synthese von selektiv geschützten Aminozuckern und ihren Derivaten über direkte organokatalytische Mannich‐Reaktion (2005)

Ein leichter Weg zu Aminozuckern: Ausgehend von den käuflichen Vorstufen 1–3 erhält man durch Prolin-katalysierte Dreikomponenten-Mannich-Reaktion in einem Schritt selektiv geschützte, hoch diastereo- und enantiomerenreine Aminozucker und ihre Derivate (siehe Schema; LM=Lösungsmittel, PMP=para-Methoxyphenyl). Dieses effiziente organokatalytische Verfahren kann im Multigramm-Maßstab durchgeführt werden.
A seismic metamaterial: The resonant metawedge (2016)

Critical concepts from three different fields, elasticity, plasmonics and metamaterials, are brought together to design a metasurface at the geophysical scale, the resonant metawedge, to control seismic Rayleigh waves. Made of spatially graded vertical subwavelength resonators on an elastic substrate, the metawedge can either mode convert incident surface Rayleigh waves into bulk elastic shear waves or reflect the Rayleigh waves creating a "seismic rainbow" effect analogous to the optical rainbow for electromagnetic metasurfaces. Time-domain spectral element simulations demonstrate the broadband efficacy of the metawedge in mode conversion while an analytical model is developed to accurately describe and predict the seismic rainbow effect; allowing the metawedge to be designed without the need for extensive parametric studies and simulations. The efficiency of the resonant metawedge shows that large-scale mechanical metamaterials are feasible, will have application, and that the time is ripe for considering many optical devices in the seismic and geophysical context.
Laser-assisted biofabrication in tissue engineering and regenerative medicine (2016)

Abstract
On-line measurement of pulp water anions by capillary electrophoresis with fast sequential sampling and dynamic solvent feeding (2002)

This paper demonstrates the use of the first on-line capillary electrophoresis instrument with continuously flowing electrolyte solutions and sequentially applied sample introduction. The system was used in on-line determination of chloride, sulfate, and carbonate concentrations of process waters at a pulp mill. The module constructed for on-line feeding of the solvents is described. Separations were performed in a pyromellitic acid-hexamethonium hydroxide-triethanol amine mixture at pH 7.7 with indirect-UV detection at 254 nm. Two standard mixtures were used to show the repeatability of the analysis and to estimate the accuracy of the on-line system. The analytes could be separated within 240 s. Sampling from a pulp machine could be accomplished on-line at 6-minute intervals. On-line tests gave a limit of detection and a limit of determination in the low mg/L range.
Ansatzpunkte zur weitergehenden Fundierung des koordinationsorientierten Controlling (1998)

Die vorliegende Arbeit sollte primär ein tiefergehendes Verständnis der koordinativen Wirkungen von Verrechnungspreisen schaffen. Andererseits dürften auch Ansatzpunkte zur weitergehenden Fundierung des Controlling aufgezeigt worden sein. Schließlich kann die Analyse von Interdependenzen als theoretische, die Schaffung und Bewertung von Koordinationsinstrumenten als Gestaltungsaufgabe des Controlling verstanden werden (vgl. Küpper [Controlling] 31). Vor allem durch die gleichzeitige Berücksichtigung sachlicher und personaler Interdependenzen zeigten sich in dieser Arbeit Ergebnisse, die auch für eine fundiertere Beurteilung anderer Koordinationsinstrumente des Controlling wichtig sein können.
One-Pot and Green Preparation of Phyllanthus emblica Extract/Silver Nanoparticles/Polyvinylpyrrolidone Spray-On Dressing (2022)

A spray-on wound dressing has many benefits, including easy and quick administration to broad and uneven wounds, better interface with the wound site, adhesion without additional dressing, and multiple applications in a portable package. By limiting direct contact with the wound site, such a design can prevent wound damage during treatment. This study revealed a simple, one-pot synthesis of spray-on wound dressing relying on polyvinylpyrrolidone solution incorporating silver nanoparticles as a broad-spectrum antibacterial agent and wound-healing antioxidant <i>Phyllanthus emblica</i> extract. Silver nanoparticles were synthesized in situ using <i>Phyllanthus emblica</i> extract as a biogenic reducing agent. Polyvinylpyrrolidone was employed as a film-forming agent to create an adhesive hydrogel-based dressing matrix to provide moisture and establish a shielding barrier for the wound bed as well as to regulate the release of fruit extract. In vitro tests revealed that the produced dressing film had a controlled release of the fruit extract, high antioxidant activity, and a good antibacterial action against <i>S. aureus</i>, <i>P. aeruginosa</i>, <i>E. coli</i>, and MRSA. Additionally, a biocompatibility study has shown that both human fibroblasts and keratinocytes are unaffected by the dressing film. Based on established findings, the current spray-on solution might be a potential option for antibacterial wound dressing.
1372: Prediction of Extra Vesical Disease by Preoperative Serum Markers in Patients with Clinically Organ Confined Invasive Bladder Cancer (2005)

ant sup with rectangular electric shock waves with 0.1 to 0.3 ms in duration and variable intensity toward the inside of the palpable surface of the iliac crest and the spontaneus and voluntary EMG activities were recorded. RESULTS: The GFN involvement was demonstrated electrophysiologically in 55% of the patients with previous herniorraphy(n:ll) and 36% of the patients with an inguinal hemia(n:4 ). As shown in table -I the significant elongated latencies were shown in all cases. (p<O.OOI). Also in 8 patients the GFN could not be evoked.
Multiquantum well electroabsorption modulators for80 Gbit/s OTDMsystems (1995)

A fully packaged electroabsorption modulator is used to generate transform limited 4.1 ps pulses at a 20 GHz repetition rate. The feasibility of using this component for short pulse generation and demultiplexing in a four channel 80 Gbit/s OTDM system is discussed.
Serum pepsinogen C: A useful marker of Helicobacter pylori eradication? (1996)

Medical treatment for Helicobacter pylori (Hp) infection is now recommended in several types of gastroduodenal disease, and its success is usually monitored by hystology. The end-points of our work were to identify the most suitable serum index of Hp eradication among pepsinogen A (PGA), pepsinogen C (PGC), PGA/PGC ratio, gastrin, and IgG anti-Hp (IGG). We studied a total of 289 Hp positive (Giemsa staining) patients, who were treated with 40 mg/day omeprazole (140 cases) or with 480 mg/day bismuth subsalicylate (149 cases) for 4 weeks. All the patients also received 1 g/day metronidazole + 2 g/day amoxycillin for the first 2 weeks of treatment. Two months after the end of therapy, the patient underwent a second endoscopy and Hp histological assessment: the infection was eradicated in 192 and still present in the remaining 97 subjects. Gastrin, PGA, PGC, and IGG were measured before and after therapy. All indices significantly decreased after therapy in eradicated patients, while PGA and gastrin significantly decreased after therapy in both eradicated and noneradicated patients, although in the latter group the variations were less pronounced. We calculated the per cent decrease of the studied indices. PGC, with a decrease of more than 25%, was found to be the most accurate biochemical index. Variation in PGC levels before and after treatment were correlated with corresponding variations in Hp bacterial load. In conclusion, between the different biochemical parameters evaluated, PGC showed the highest clinical efficiency.
A writer's collaborative assistant (2002)

In traditional human-computer interfaces, a human master directs a computer system as a servant, telling it not only what to do, but also how to do it. Collaborative interfaces attempt to realign the roles, making the participants collaborators in solving the person's problem. This paper describes Writer's Aid, a system that deploys AI planning techniques to enable it to serve as an author's collaborative assistant. Writer's Aid differs from previous collaborative interfaces in both the kinds of actions the system partner takes and the underlying technology it uses to do so. While an author writes a document, Writer's Aid helps in identifying and inserting citation keys and by autonomously finding and caching potentially relevant papers and their associated bibliographic information from various on-line sources. This autonomy, enabled by the use of a planning system at the core of Writer's Aid, distinguishes this system from other collaborative interfaces. The collaborative design and its division of labor result in more efficient operation: faster and easier writing on the user's part and more effective information gathering on the part of the system. Subjects in our laboratory user study found the system effective and the interface intuitive and easy to use.
The mummified brain of a pleistocene woolly mammoth (Mammuthus primigenius) compared with the brain of the extant African elephant (Loxodonta africana) (2015)

ABSTRACT This study presents the results of an examination of the mummified brain of a pleistocene woolly mammoth ( Mammuthus primigenius ) recovered from the Yakutian permafrost in Siberia, Russia. This unique specimen (from 39,440–38,850 years BP) provides the rare opportunity to compare the brain morphology of this extinct species with a related extant species, the African elephant ( Loxodonta africana ). An anatomical description of the preserved brain of the woolly mammoth is provided, along with a series of quantitative analyses of various brain structures. These descriptions are based on visual inspection of the actual specimen as well as qualitative and quantitative comparison of computed tomography imaging data obtained for the woolly mammoth in comparison with magnetic resonance imaging data from three African elephant brains. In general, the brain of the woolly mammoth specimen examined, estimated to weigh between 4,230 and 4,340 g, showed the typical shape, size, and gross structures observed in extant elephants. Quantitative comparative analyses of various features of the brain, such as the amygdala, corpus callosum, cerebellum, and gyrnecephalic index, all indicate that the brain of the woolly mammoth specimen examined has many similarities with that of modern African elephants. The analysis provided here indicates that a specific brain type representative of the Elephantidae is likely to be a feature of this mammalian family. In addition, the extensive similarities between the woolly mammoth brain and the African elephant brain indicate that the specializations observed in the extant elephant brain are likely to have been present in the woolly mammoth. J. Comp. Neurol. 523:2326–2343, 2015. © 2015 Wiley Periodicals, Inc.
Waste encapsulation and storage facility ventilation system (1973)

Calcium-enriched compounds have great potential in the treatment of heavy-metal contaminated wastewater. Preparing stable basic calcium carbonate (BCC), which is a calcium-enriched compound, and applying it in practice is a great challenge. This work investigated the formation process of hierarchical hydroxyapatite (HAP)/BCC nanocomposites and their adsorption behaviors regarding lead ions (Pb<sup>2+</sup>). The morphology of the HAP/BCC nanocomposite was controlled by the addition of monododecyl phosphate (MDP). The carnation-like HAP/BCC nanocomposite was achieved with the addition of 30 g of MDP. The carnation-like HAP/BCC nanocomposite had a high Pb<sup>2+</sup> adsorption capacity of 860 mg g<sup>-1</sup>. The pseudo-second-order and Freundlich model simulation results indicated that the adsorptions of Pb<sup>2+</sup> on the nanocomposites belonged to the chemisorption and multilayer adsorption processes. The main effective adsorption components for the nanocomposites were calcium-enriched HAP and BCC. Through the Ca<sup>2+</sup> ions exchanging with Pb<sup>2+</sup>, the HAP and BCC phases were converted to hydroxyl-pyromorphite (Pb-HAP) and hydrocerussite (Pb<sub>3</sub>(CO<sub>3</sub>)<sub>2</sub>(OH)<sub>2</sub>), respectively. The carnation-like HAP/BCC nanocomposite has great potential in the treatment of heavy metal ions. This facile method provides a new method for preparing a stable HAP/BCC nanocomposite and applying it in practice.
Potential Therapeutic Targets for Steroid-Resistant Asthma (2010)

Glucocorticoids are the mainstay of asthma management and effectively treat acute exacerbations of asthma. However, a small subset of asthmatics, usually with severe asthma, respond poorly even to systemic administration of high-dose glucocorticoids and this condition is termed "steroid-resistant asthma". This cohort, although small, accounts for approximately 50% of total health care cost for asthma. New investigations into the mechanisms of glucocorticoid action have broadened and deepened our understanding of glucocorticoid resistance. Here we review the importance and characteristics of steroid resistant asthma, the mechanisms that mediate the function of glucocorticoids and that lead to the development of this disease and potential therapies to reverse resistance to treatment. Cellular and molecular factors, receptors and complex signalling pathways have all been implicated. Indeed, based on molecular biological studies, excessive activation of intracellular transcription factors, impaired histone deacetylase, and epigenetic (such as miR-18 and miR-124a) as well as other factors (e.g. vitamin D, P-glycoprotein 170, and macrophage migration inhibitory factor and T helper 17 cells and factors related to innate immunity (such as IFN-gamma and LPS)) may result in glucocorticoid resistance. A thorough understanding of the pathogenesis of steroid resistant asthma will help to develop more efficacious agents for the treatment of the disease.
Policy Optimization by Genetic Distillation (2017)

Genetic algorithms have been widely used in many practical optimization problems. Inspired by natural selection, operators, including mutation, crossover and selection, provide effective heuristics for search and black-box optimization. However, they have not been shown useful for deep reinforcement learning, possibly due to the catastrophic consequence of parameter crossovers of neural networks. Here, we present Genetic Policy Optimization (GPO), a new genetic algorithm for sample-efficient deep policy optimization. GPO uses imitation learning for policy crossover in the state space and applies policy gradient methods for mutation. Our experiments on MuJoCo tasks show that GPO as a genetic algorithm is able to provide superior performance over the state-of-the-art policy gradient methods and achieves comparable or higher sample efficiency.
The influence of neutron irradiation on the magnetic relaxation spectrum of commercial non-oriented iron-silicon steel (1985)

Magnetic after-effect measurements are made in the temperature range 200 to 800 K on commercially produced Fe-Si-Al electric sheets following irradiation at 320 K. with fast neutrons up to integrated doses of 5 × 1022 m−2. The dose dependence and the annealing behaviour of the magnetic after-effects are investigated. The results are compared with earlier measurements made within the same temperature range on unirradiated material and are discussed in terms of dislocation relaxations and also Zener relaxations due to the reorientation of pairs of solute atoms. An essential effect of n-irradiation at 320 K consists in dislocation pinning. Magnetische Nachwirkungsmessungen werden in technischen Fe-Si-Al-Trafoblechen im Temperaturbereich zwischen 200 und 800 K nach Neutronenbestrahlung bei 320 K mit Dosen von 1021 bis 5 × 1022 Neutronen m−2 durchgeführt. Die Dosisabhängigkeit und das Anlaßverhalten der magnetischen Nachwirkung werden untersucht. Die Ergebnisse werden mit früheren Messungen an unbestrahltem Material innerhalb desselben Temperaturbereichs verglichen und werden Versetzungsrelaxationen sowie Zener-Relaxationen infolge Umorientierung von substitutionell gelösten Atompaaren zugeschrieben. Eine wesentliche Auswirkung der n-Bestrahlung bei 320 K besteht in der Verankerung der Versetzungen.
Chirality in conjugated polymers: when two components meet (2012)

Chirality is a well-studied feature in the auspicious class of conjugated polymers. Proper use allows us to study and to control the behavior of the polymers which make them very valuable in many applications. Mostly chiral homopolymers are considered, but what happens when the chirality originates from the interplay between multiple components? This review summarizes different approaches to implement multicomponent chirality in conjugated polymers and their properties.
Status of HiLASE project: High average power pulsed DPSSL systems for research and industry (2013)

We introduce the Czech national R&D project HiLASE which focuses on strategic development of advanced high-repetition rate, diode pumped solid state laser (DPSSL) systems that may find use in research, high-tech industry and in the future European large-scale facilities such as HiPER and ELI. Within HiLASE we explore two major concepts: thin-disk and cryogenically cooled multislab amplifiers capable of delivering average output powers above 1 kW level in picosecond-to-nanosecond pulsed regime. In particular, we have started a programme of technology development to demonstrate the scalability of multislab concept up to the kJ level at repetition rate of 1–10 Hz.