gebhart/patrepeval huggingface dataset:
Correlation between tumor necrosis factor‐α (TNF‐α)‐induced cytoskeletal changes and human collagenase gene induction (1992)

Tumor necrosis factor-alpha (TNF-alpha) has been shown not only to induce the biosynthesis and secretion of collagenase but also to change the organization of cytoskeletal components. In the present study we explore the correlation between the biosynthesis of collagenase (by mRNA hybridization, indirect immunofluorescence and collagenolytic activity), and cytoskeletal reorganization (by rhodamine-phalloidin staining of F-actin) induced in fibroblasts by recombinant TNF (rTNF). In the concentration range of 1-100 ng/ml, rTNF increased extracellular collagenase activity 8-fold and collagenase mRNA 4-fold. In addition, whereas the collagenase mRNA was detected as early as 24 h posttreatment, the appearance of extracellular collagenase activity required 48 h. Using phalloidin to follow the organization of the cytoskeleton we observed that rTNF disrupted the parallel array of stress fibers normally observed in the perinuclear region. In contrast to the time required to affect collagenase synthesis, the effect of rTNF on stress fiber organization occurred as early as 6 h post-treatment. Finally, while the number of cells exhibiting this change increased with increasing concentrations of rTNF, a maximum of about 30% of the cells showed this effect. Interestingly, double staining studies demonstrated that both stress fiber changes and procollagenase production occurred in the same cells. This finding, together with the observation that the cytoskeletal disorganization preceded collagenase gene induction by at least 18 h is consistent with the conclusion that the organizational status of the microfilaments may have a role as a regulator of procollagenase gene expression.
Summation identities for representation of certain real numbers (2006)

We present identities used to represent real numbers of the form x u m ± y v n for appropriately chosen real numbers x , y , u , v and nonnegative integers m and n . We present the proofs of the identities by applying Zeilberger′s algorithm.
Orientation-dependent electro-optical response of BaTiO_3 on SrTiO_3-buffered Si(001) studied via spectroscopic ellipsometry (2017)

To design a high performance BaTiO 3 (BTO)-integrated Si modulator, understanding how BTO domain orientations influence its electro-optical (EO) properties is crucial.The 100-nm-thick BTO films with c-oriented and a-oriented domains are obtained by exploiting various thickness of SrTiO 3 buffer layers grown on Si(001) substrates.Then, the electro-optical behavior for 2 differently oriented samples is analyzed using spectroscopic ellipsometry.
Identification and validation of oncologic disease drug targets by in vivo functional genomic analysis (2005)

9562 The sequencing of the human genome has provided an unprecedented opportunity to identify novel drug targets that can enable the discovery of new therapeutics. It is critical to identify the key genetic targets that, when modulated, can produce therapeutic effects. This is particularly true of cancer in which the relationships between gene target, disease, and therapy have been explored perhaps more than any other disease. Gene knockout (KO) mice can be used to identify novel drug targets for cancer through in-depth phenotypic analysis designed to detect new mechanisms regulating cell cycle, apoptosis, DNA repair, and tissue development. By inactivation of specific genes, KO mice may be used to genetically model the actions of perfectly selective and potent chemical or biological antagonists. Careful analysis of the phenotypes of KO mice can allow one to make predictions with regard to mechanism of action and potential on-target side effects of future drugs without having to first develop a candidate therapeutic agent with which to validate the target. The power of this approach has been demonstrated by studies examining the targets of the best-selling drugs and current pharmaceutical pipelines. These analyses revealed that the therapeutic effect of established drugs show a strong correlation with the KO mouse phenotype of the corresponding target. We have implemented this target validation approach by developing systems and infrastructure to generate and comprehensively phenotype mutant mice at a rate of more than fifteen targets per week. The battery of tests encompassed by our analysis has been specifically selected to reveal those genes that encode key control points in mammalian physiology and behavior. Tests to detect potential oncology targets include: fibroblast proliferation assay, radiation sensitivity, gene expression profiling, developmental defects in the mammary gland and other tissues, angiogenesis, and embryonic lethality. For targets found to be of interest, additional assays are performed to more thoroughly examine gene function. Data will be presented illustrating the process from knockout through an oncologic phenotypic analysis as part of an integrated cancer drug discovery program. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Lexicon Genetics Lexicon Genetics
Abnormal XY Interchange between a Novel Isolated Protein Kinase Gene, PRKY, and Its Homologue, PRKX, Accounts for One Third of All (Y+)XX Males and (Y-)XY Females (1997)

XX males and XY females have a sex reversal disorder which can be caused by an abnormal interchange between the X and the Y chromosomes. We have isolated and characterized a novel gene on the Y chromosome, PRKY. This gene is highly homologous to a previously isolated gene from Xp22.3, PRKX, and represents a member of the cAMP-dependent serine threonine protein kinase gene family. Abnormal interchange can occur anywhere on Xp/Yp proximal to SRY. We can show that abnormal interchange happens particularly frequently between PRKX and PRKY. In a collection of 26 XX males and four XY females, between 27 and 35% of the interchanges take place between PRK homologues but at different sites within the gene. PRKY and PRKX are located far from the pseudoautosomal region where XY exchange normally takes place. The unprecedented high sequence identity and identical orientation of PRKY to its homologous partner on the X chromosome, PRKX, explains the high frequency of abnormal pairing and subsequent ectopic recombination, leading to XX males and XY females and to the highest rate of recombination outside the pseudoautosomal region.
GEOFFREY HILL'S ‘CHRISTIAN YEAR’ (1979)

GEOFFREY HILL'S ‘CHRISTIAN YEAR’ Get access Tenebrae. By GEOFFREY HILL. Deutsch, 1978; £2.50. BRIAN OXLEY BRIAN OXLEY Birmingham University Search for other works by this author on: Oxford Academic Google Scholar Essays in Criticism, Volume XXIX, Issue 3, July 1979, Pages 285–292, https://doi.org/10.1093/eic/XXIX.3.285 Published: 01 July 1979
Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo (2003)

Phosphocreatine (PCr) resynthesis rate following intense anoxic contraction can be used as a sensitive index of in vivo mitochondrial function. We examined the effect of a diet-induced increase in uncoupling protein 3 (UCP3) expression on postexercise PCr resynthesis in skeletal muscle. Nine healthy male volunteers undertook 20 one-legged maximal voluntary contractions with limb blood flow occluded to deplete muscle PCr stores. Exercise was performed following 7 days consumption of low-fat (LF) or high-fat (HF) diets. Immediately following exercise, blood flow was reinstated, and muscle was sampled after 20, 60, and 120 seconds of recovery. Mitochondrial coupling was assessed by determining the rate of PCr resynthesis during recovery. The HF diet increased UCP3 protein content by approximately 44% compared with the LF diet. However, this HF diet-induced increase in UCP3 expression was not associated with any changes in the rate of muscle PCr resynthesis during conditions of maximal flux through oxidative phosphorylation. Muscle acetylcarnitine, free-creatine, and lactate concentrations during recovery were unaffected by the HF diet. Taken together, our findings demonstrate that increasing muscle UCP3 expression does not diminish the rate of PCr resynthesis, allowing us to conclude that the primary role of UCP3 in humans is not uncoupling.
ENO2 activity is required for the development and reproductive success of plants, and is feedback‐repressed by AtMBP‐1 (2015)

Enolases are key glycolytic enzymes that are highly conserved in prokaryotic and eukaryotic organisms, and are among the most abundant cytosolic proteins. In this study we provide evidence that activity of the enolase ENO2 is essential for the growth and development of plants. We show that Arabidopsis plants with compromised ENO2 function, which were generated by mutating the LOS2/ENO2 locus, have severe cellular defects, including reduced cell size and defective cell differentiation with restricted lignification. At the tissue and organ level LOS2/ENO2-deficient plants are characterized by the reduced growth of shoots and roots, altered vascular development and defective secondary growth of stems, impaired floral organogenesis and defective male gametophyte function, resulting in embryo lethality as well as delayed senescence. These phenotypes correlate with reduced lignin and increased salicylic acid contents as well as altered fatty acid and soluble sugar composition. In addition to an enolase the LOS2/ENO2 locus encodes the transcription factor AtMBP-1, and here we reveal that this bifunctionality serves to maintain the homeostasis of ENO2 activity. In summary, we show that in plants enolase function is required for the formation of chorismate-dependent secondary metabolites, and that this activity is feedback-inhibited by AtMBP-1 to enable the normal development and reproductive success of plants.
Extremely asynchronic delivery of second and third fetuses in a triple pregnancy (2014)

Report of clinical treatment of a patient with a triple pregnancy after ICSI, who had the abortion of the first fetus at 16 weeks of gestation and the "asynchronic delivery" of the other two, at 28 weeks. A reproductive inflammatory process previously diagnosed in the couple could have been related with the premature rupture of membranes (PROM) occurred at 15.5 weeks of pregnancy. The clinical interventions described, made possible the delayed delivery and the survival of the other two triplets. This case shows us the importance to transfer no more than two embryos during ART, to avoid the catastrophic consequences of a triple pregnancy.
Conservation in the first internal transcribed spacer (ITS1) region of Hematodinium perezi (genotype III) from Callinectes sapidus (2012)

Hematodinium spp. infections have been reported from blue crabs Callinectes sapidus in high-salinity waters of the USA from New Jersey to Texas. Recently, H. perezi (genotype III) has been proposed as the parasite species and genotype infecting blue crabs from Virginia; however, it is unknown whether this same genotype is present in blue crabs from other locations. To address this question, we collected 317 blue crabs from Massachusetts, Virginia, Georgia, Florida, Louisiana, and Texas to test for the presence of H. perezi (III) using a specific PCR assay targeting the first internal transcribed spacer (ITS1) region of the ribosomal RNA gene complex. To examine the genetic variation within H. perezi (III), ITS1 region sequences from the parasite in blue crabs from multiple locations were compared to each other and to those of H. perezi (III) found in alternate hosts from Virginia. In total, 34 distinct ITS1 sequence variants of the parasite were identified from blue crabs alone, and 38 distinct variants were identified when alternate hosts were included. However, a single ITS1 sequence variant appeared in all geographic regions and hosts, and also in blue crabs sampled from a previous study. The high similarity among all the ITS1 region sequences examined (>98%) and the observation of a single variant found throughout a large geographic range, strongly suggests that a single species and genotype of Hematodinium, specifically H. perezi (III), infects blue crabs from Virginia to Texas and multiple alternate host species in Virginia.
The Novel 21-Aminosteroid U74006F Attenuates Cerebral Edema and Improves Survival after Brain Injury in the Rat (1992)

The present study evaluated the effect of the nonglucocorticoid 21-aminosteroid U74006F, an inhibitor of iron-dependent lipid peroxidation, on the development of regional cerebral edema after lateral fluid-percussion (FP) brain injury. Male Sprague-Dawley rats (n = 40) were anesthetized and subjected to FP brain injury of moderate severity centered over the left parietal cortex (2.5-2.6 atms). Fifteen minutes after brain injury, animals randomly received an i.v. bolus of either U74006F (3 mg/kg, n = 21) followed by a second bolus (3 mg/kg) at 3 hr or buffered sodium citrate vehicle (equal volume, n = 15). An additional group of 12 surgically prepared but uninjured animals served as preinjury controls. At 48 hr after injury, animals were sacrificed and brain tissue assayed for water content and regional cation concentrations. With the use of specific gravimetric techniques, no significant differences were observed in posttraumatic cerebral edema between drug- and control-treated animals. However, using wet weight/dry weight methodology, we found that administration of U74006F significantly reduced water content in the right hippocampus (contralateral to the site of injury) compared to saline-treated animals (p less than 0.05). U74006F also significantly prevented the postinjury increase in sodium concentrations in the ipsilateral hippocampus (p less than 0.05) and thalamus (p less than 0.03). Regional concentrations of potassium were unaltered after drug treatment. Administration of U74006F significantly reduced postinjury mortality, from 28% in control animals to zero in treated animals (p = 0.01). These results suggest that lipid peroxidation may be involved in the pathophysiological sequelae of brain injury and that 21-aminosteroids may be beneficial in the treatment of brain injury.
Intermodal frequency generation in silicon-rich silicon nitride waveguides (2019)

Dispersion engineering in optical waveguides allows applications relying on the precise control of phase matching conditions to be implemented. Although extremely effective over relatively narrow band spectral regions, dispersion control becomes increasingly challenging as the bandwidth of the process of interest increases. Phase matching can also be achieved by exploiting the propagation characteristics of waves exciting different spatial modes of the same waveguide. Phase matching control in this case relies on achieving very similar propagation characteristics across two, and even more, waveguide modes over the wavelengths of interest, which may be rather far from one another. We demonstrate here that broadband (&amp;gt;40 nm) four-wave mixing can be achieved between pump waves and a signal located in different bands of the communications spectrum (separated by 50 nm) by exploiting interband nonlinearities. Our demonstration is carried out in the silicon-rich silicon nitride material platform, which allows flexible device engineering, allowing for strong effective nonlinearity at telecommunications wavelengths without deleterious nonlinear-loss effects.
Evaluation of material based influences at laser based heat conduction welding of CFRP (2018)

Today, fiber reinforced materials are present in a wide field of industrial applications. Short glass fiber reinforced composites are used in automotive, aerospace and medical sectors. In the last couple of years, fiber reinforced thermoplastics have gained importance as construction material, especially for light weight assembly. There are different methods of joining thermoplastic materials such as vibration, resistance and induction welding. A more advanced process is the laser transmission welding, which can be characterized by its excellent reproducibility, high flexibility and potential for automation. Laser transmission welding can be applied for joining unreinforced or glass fiber reinforced thermoplastic parts. This welding process was transferred to heat conduction welding for joining thermoplastic CFRP to itself. Goal of these investigations was to determine the influence of the material thickness on the weld seam quality.
Design criteria for microstructured-optical-fiber-based surface-plasmon-resonance sensors (2007)

Design strategies for microstructured-optical-fiber (MOF-) based surface-plasmon-resonance (SPR) sensors are presented. In such sensors, plasmons on the inner surface of the large metallized channels containing analyte can be excited by a fundamental mode of a single-mode microstructured fiber. Phase matching between a plasmon and a core mode can be enforced by introducing air-filled microstructures into the fiber core. Particularly, in its simplest implementation, the effective refractive index of a fundamental mode can be lowered to match that of a plasmon by introducing a small central hole into the fiber core. Resolution of the MOF-based sensors is demonstrated to be as low as 3×10−5 RIU, where RIU means refractive index unit. The ability to integrate large-size microfluidic channels for efficient analyte flow together with a single-mode waveguide of designable modal refractive index is attractive for the development of integrated highly sensitive MOF-SPR sensors operating at any designable wavelength.
El absentismo escolar como reto para la calidad educativa (2003)

Este trabajo merecio el Segundo Premio Nacional de Investigacion Educativa 2003. El proyecto afronta el problema del absentismo escolar desde la perspectiva de la intervencion educativa local integrada, con el proposito de mejorar el denominado exito escolar.
A novel type of mixer used for direct frequency synthesis (2009)

The frequency synthesizers are an essential part of any modern communications system. They generate clock and oscillator signals needed for up and down conversion. Today's communication standards demand both high frequency accuracy and fast frequency settling. The fine frequency resolution is usually desired and low spurious signals, accuracy and stability are also most important for these devices. For some types of the frequency synthesizer the mixer is very significant part. In this paper, the frequency synthesizer architecture based on direct synthesis described. More over the new coincidence mixer used in this synthesizer is presented. The mathematic derivation and simulation results are also shown.
High photon flux atto-second sources at the Lund Laser Centre (2014)

We provide an update on our high photon flux atto-second sources: an XUV source with ~1011 photons/pulse for nonlinear atto-second experiments and a 200 kHz XUV source with ~1011 photons/second for electron-imaging and coincidence experiments.
3 Stars on Yelp, 4 Stars on Google Maps (2021)

Even though a restaurant may receive different ratings across review platforms, people often see only one rating during a local search (e.g. 'best burgers near me'). In this paper, we examine the differences in ratings between two commonly used review platforms-Google Maps and Yelp. We found that restaurant ratings on Google Maps are, on average, 0.7 stars higher than those on Yelp, with the increase being driven in large part by higher ratings for chain restaurants on Google Maps. We also found extensive diversity i¬¬n top-ranked restaurants by geographic region across platforms. For example, for a given metropolitan area, there exists little overlap in its top ten lists of restaurants on Google Maps and Yelp. Our results problematize the use of a single review platform in local search and have implications for end users of ratings and local search technologies. We outline concrete design recommendations to improve communication of restaurant evaluation and discuss the potential causes for the divergence we observed.
Electrophysiologic Scar Substrate in Relation to VT: Noninvasive High‐Resolution Mapping and Risk Assessment with ECGI (2016)

ECGI noninvasively identified scar EP substrate that underlies abnormal conduction in ICM patients. It identified regions within the scar that aligned with critical elements of the reentry circuit during VT. ECGI can potentially be used for VT risk stratification in ICM patients.
Speaker-adaptive speech synthesis based on eigenvoice conversion and language-dependent prosodic conversion in speech-to-speech translation (2011)

INTERSPEECH 2011: 12th Annual Conference of the International Speech Communication Association, 28-31 August, 2011, Florence, Italy.
A Development of VR Surgical Simulator for Training of Operations Skill (2009)

The authors have been developing a practical surgical simulator since 2004 under the contract of National Institute of Information and Communications Technology (NICT). Unlike already commercialized laparoscopic surgical simulators, our surgical simulator is capable for training to improve operation skill and preoperative trainings using particular patients' data. We have completed engineering related development of the simulation-platform, and are now carrying out implementation of urinary organ related laparoscopic operation procedure on the platform with Yokohama City University graduate school of medicine course which is a collaborative research organization.
Poorly Differentiated Squamous Cell Carcinoma Arising in Tattooed Skin (2010)

Introduction. Tattoos have increasingly become accepted by mainstream Western society. As a result, the incidence of tattoo-associated dermatoses is on the rise. The presence of a poorly differentiated squamous cell carcinoma in an old tattooed skin is of interest as it has not been previously documented. Case Presentation. A 79-year-old white homeless man of European descent presented to the dermatology clinic with a painless raised nodule on his left forearm arising in a tattooed area. A biopsy of the lesion revealed a poorly differentiated squamous cell carcinoma infiltrating into a tattoo. The lesion was completely excised and the patient remains disease-free one year later. Conclusion. All previous reports of squamous cell carcinomas arising in tattoos have been well-differentiated low-grade type or keratoacanthoma-type and are considered to be coincidental rather than related to any carcinogenic effect of the tattoo pigments. Tattoo-associated poorly differentiated invasive carcinoma appears to be extremely rare.
Quantum algorithm for simulating the wave equation (2019)

We present a quantum algorithm for simulating the wave equation under Dirichlet and Neumann boundary conditions. The algorithm uses Hamiltonian simulation and quantum linear system algorithms as subroutines. It relies on factorizations of discretized Laplacian operators to allow for polynomially improved scaling in truncation errors and improved scaling for state preparation relative to general purpose quantum algorithms for solving linear differential equations. Relative to classical algorithms for simulating the $D$-dimensional wave equation, our quantum algorithm achieves exponential space savings and achieves a speedup which is polynomial for fixed $D$ and exponential in $D$. We also consider using Hamiltonian simulation for Klein-Gordon equations and Maxwell's equations.