gebhart/patrepeval huggingface dataset:
New Types of Homochiral Helical Coordination Polymers Constructed by exo‐Bidentate Binaphthol Derivatives (2004)

Abstract Assembly of axially chiral ( S )‐2,2′‐bis(3‐pyridylmethyleneoxy)‐1,1′‐binaphthalene [( S )‐L 1 ] and ( S )‐2,2′‐bis(4‐pyridylmethyleneoxy)‐1,1′‐binaphthalene [( S )‐L 2 ] with AgNO 3 resulted in a double‐stranded helical coordination polymer encapsulating guest water molecules and a helix‐like complex with inter‐immersion clefts, respectively, in which helical chirality is due to axial chirality of the 1,1′‐bi‐2‐naphthol scaffold. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2004)
Faculty Opinions recommendation of Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. (2004)

The BTB/POZ transcriptional repressor and candidate oncogene BCL6 is frequently misregulated in B-cell lymphomas. The interface through which the BCL6 BTB domain mediates recruitment of the SMRT, NCoR and BCoR corepressors was recently identified. To determine the contribution of this interface to BCL6 transcriptional and biological properties, we generated a peptide that specifically binds BCL6 and blocks corepressor recruitment in vivo. This inhibitor disrupts BCL6-mediated repression and establishment of silenced chromatin, reactivates natural BCL6 target genes, and abrogates BCL6 biological function in B cells. In BCL6-positive lymphoma cells, peptide blockade caused apoptosis and cell cycle arrest. BTB domain peptide inhibitors may constitute a novel therapeutic agent for B-cell lymphomas. PMID: 15531890 Funding information This work was supported by: NCI NIH HHS, United States Grant ID: CA99982 NCI NIH HHS, United States Grant ID: CA59936
Abstract IA18: A brain metastasis-promoting role for cathepsin S identified from analysis of tumor- and stroma-supplied proteolytic networks (2015)

Abstract Cancer cells in an aggressive primary tumor are adept at exploiting their local tissue microenvironment. In contrast, when metastatic cells leave these favorable surroundings, they must possess or acquire traits that will allow them to survive and colonize foreign, potentially hostile tissue environments. The obstacles that metastasizing tumor cells encounter vary from organ to organ, and are highly influenced by non-cancerous stromal cells of the tumor microenvironment. For example, the blood-brain barrier, composed of endothelial cells, astrocytes and pericytes, presents a far more formidable structure for tumor cells to penetrate, compared to the fenestrated capillaries in the bone marrow. While the primary tumor microenvironment has emerged as an important regulator of cancer progression, it is less well understood how different tissue environments influence metastatic processes. We used a dual species-specific microarray platform to uncover tumor-stroma interactions that modulate organ tropism of brain, bone and lung metastasis in animal models of cancer. Among the differentially regulated tumor- and stroma-specific genes, we identified cathepsin S as a novel regulator of breast-to-brain metastasis. In breast cancer patients, high cathepsin S expression at the primary site correlated with decreased brain metastasis-free survival. Both macrophages and tumor cells produce cathepsin S, and only the combined depletion significantly reduced brain metastasis in experimental models in vivo. We show that cathepsin S specifically mediates blood-brain barrier transmigration via proteolytic processing of the junctional adhesion molecule (JAM)-B. Pharmacological inhibition of cathepsin S significantly reduced experimental brain metastasis, supporting its consideration as a therapeutic target for this disease. Citation Format: Lisa Sevenich, Robert Bowman, Steve Mason, Daniela Quail, Franck Rapaport, Benelita Elie, Edi Brogi, Priscilla Brastianos, William Hahn, Leslie Holsinger, Joan Massagué, Christina Leslie, Johanna A. Joyce. A brain metastasis-promoting role for cathepsin S identified from analysis of tumor- and stroma-supplied proteolytic networks. [abstract]. In: Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr IA18. doi:10.1158/1538-7445.CHTME14-IA18
Consistent cooperative localization (2009)

In cooperative navigation, teams of mobile robots obtain range and/or angle measurements to each other and dead-reckoning information to help each other navigate more accurately. One typical approach is moving baseline navigation, in which multiple Autonomous Underwater Vehicles (AUVs) exchange range measurements using acoustic modems to perform mobile trilateration. While the sharing of information between vehicles can be highly beneficial, exchanging measurements and state estimates can also be dangerous because of the risk of measurements being used by a vehicle more than once; such data re-use leads to inconsistent (overconfident) estimates, making data association and outlier rejection more difficult and divergence more likely. In this paper, we present a technique for the consistent cooperative localization of multiple AUVs performing mobile trilateration. Each AUV establishes a bank of filters, performing careful bookkeeping to track the origins of measurements and prevent the use any of the measurements more than once. The multiple estimates are combined in a consistent manner, yielding conservative covariance estimates. The technique is illustrated using simulation results. The new method is compared side-by-side with a naive approach that does not keep track of the origins of measurements, illustrating that the new method keeps conservative covariance bounds whereas state estimates obtained with the naive approach become overconfident and diverge.
Spectral methods and their implementation to solution of aerodynamic and fluid mechanic problems (1987)

Abstract Fundamental concepts underlying spectral collocation methods, especially pertaining to their use in the solution of partial differential equations, are outlined. Theoretical accuracy results are reviewed and compared with results from test problems. A number of practical aspects of the construction and use of spectral methods are detailed, along with several solution schemes which have found utility in applications of spectral methods to practical problems. Results from a few of the successful applications of spectral methods to problems of aerodynamic and fluid mechanic interest are then outlined, followed by a discussion of the problem areas in spectral methods and the current research under way to overcome these difficulties.
Consequences of chirality on the dynamics of a water-soluble supramolecular polymer (2015)

Abstract The rational design of supramolecular polymers in water is imperative for their widespread use, but the design principles for these systems are not well understood. Herein, we employ a multi-scale (spatial and temporal) approach to differentiate two analogous water-soluble supramolecular polymers: one with and one without a stereogenic methyl. Initially aiming simply to understand the molecular behaviour of these systems in water, we find that while the fibres may look identical, the introduction of homochirality imparts a higher level of internal order to the supramolecular polymer. Although this increased order does not seem to affect the basic dimensions of the supramolecular fibres, the equilibrium dynamics of the polymers differ by almost an order of magnitude. This report represents the first observation of a structure/property relationship with regard to equilibrium dynamics in water-soluble supramolecular polymers.
CODED STRUCTURED LIGHT STRIPE BOUNDARY LOCATION WITH SUB-PIXEL ACCURACY BASED ON WEIGHTED CENTROID METHOD (2010)

Sub-pixel accuracy stripe boundary location is essential for stripe coded structured light based 3D reconstruction. So far, the intersecting point method might be the most accurate for stripe boundary location. But in this method two groups of patterns have to be projected, where one group is normal and the other is inverse patterns. So the intersecting point method can not be used in several time- or resource-constrained applications because of its complexity of projection. In this paper, after a brief survey on several commonly used stripe boundary detection methods, an improved sub-pixel location scheme based on weighted centroid algorithm is proposed. In the proposed scheme, a green slit is first added between every stripe to avoid false detection and false rejection. Then, universal gravity-based edge detection and weighted centroid method are utilized for sub-pixel location. Compared with the intersecting point method, the proposed location scheme can achieve comparable detection accuracy with only half number of patterns projected.
Variability of the genetic contribution of Quebec population founders associated to some deleterious genes. (1995)

Relatively high frequencies of some rare inherited disorders can be found in the Saguenay Region (Quebec). To understand this phenomenon, a research project on the 17th-century founder effect that led to the formation of French Canadians' gene pool is being carried out. The focus of this study is on founders who contributed to the Saguenay gene pool and who are related to contemporary probands suffering from any one of five hereditary diseases: cystic fibrosis, tyrosinemia, hemochromatosis, Charlevoix-Saguenay spastic ataxia, and sensorimotor polyneuropathia with or without agenesis of the corpus callosum. A control group has been added for comparison purposes. Altogether, 545 ascending genealogies have been reconstructed, using the Interuniversity Institute for Population Research's RETRO database, leading to > 2,500 founders. The genetic contribution of each founder to each group has been measured. Results show that (1) nearly 80% of the individuals' gene pool come from founders who settled in Nouvelle-France in the 17th century, whatever the group; (2) 15% of the founders explain 90% of the total genetic contribution of the founders, but this pattern varies from one group to another; (3) there is no subgroup of founders more related to any given group of individuals.
Combined Well Treatment with Various Chemical Compositions and Thermal Methods (2019)

This paper presents the field tests results of the combined application of chemical compositions with various functional purposes, gel-forming, intensifying and oil-displacing, in combination with thermal methods of oil recovery. A complex application, in combination with other technologies, of an acid oil-displacing and intensifying composition with prolonged action based on surfactants, inorganic acid adducts and polyatomic alcohol is considered. Field tests were carried out on the Permian- Carboniferous reservoir of the Usinsk high-viscosity oil field, Komi Republic, Russia. The results of two treatments are presented: a hot water injection horizontal well and a production cyclic steam stimulated (CSS) well. It is concluded that it is necessary to combine various methods of enhanced oil recovery to achieve higher efficiency
Order-disorder transition and magnetic quantum oscillations in the vortex state of strong type-II superconductors (2012)

We present results of μSR, dHvA and SQUID magnetization measurements on borocarbide superconductors, which show a remarkable correlation between an order-disorder transition of the vortex lattice, observed in the μSR measurements and enhanced additional damping of dHvA oscillations in the peak-effect region. It is, therefore, concluded that an important mechanism of additional damping of dHvA oscillations in the superconducting state should be associated with enhanced scattering of quasi particles by the pair potential in disordered vortex lattices.
Choice of conditions of an electrical discharge for generating chemically active particles for the decomposition of impurities in water (1999)

An electrical discharge between a liquid surface and an electrode positioned above it is considered. A second electrode, which delivers the output from a high-voltage source, is located at the bottom of the vessel containing the liquid. The conditions that must be met by the electrical discharge in order to efficiently initiate reactions in the liquid phase are analyzed. Under these conditions the number of active particles generated by the discharge turns out to depend on the concentration in the liquid of the substance with which the active particles interact. It is shown that for a corona or spark discharge the reactions can occur in a liquid layer 10–20 mm thick and that for specific reactions there exists an optimum value of the electric field at which the energy expenditures on the initiation of the reaction will be minimum.
Geometric Potential and Transport in Photonic Topological Crystals (2010)

We report on the experimental realization of an optical analogue of a quantum geometric potential for light wave packets constrained on thin dielectric guiding layers fabricated in silica by the femtosecond laser writing technology. We further demonstrate the optical version of a topological crystal, with the observation of Bloch oscillations and Zener tunneling of a purely geometric nature.
Unmasking a two-faced protein (2022)

Single-molecule fluorescence spectroscopy and molecular dynamics simulations illuminate the structure and dynamics of PSD-95, a protein involved in neural plasticity.
Gender-Sensitive Violence Risk Assessment: Predictive Validity of Six Tools in Female Forensic Psychiatric Patients (2019)

Most violence risk assessment tools have been validated predominantly in males. In this multicenter study, the Historical, Clinical, Risk Management–20 (HCR-20), Historical, Clinical, Risk Management–20 Version 3 (HCR-20 V3 ), Female Additional Manual (FAM), Short-Term Assessment of Risk and Treatability (START), Structured Assessment of Protective Factors for violence risk (SAPROF), and Psychopathy Checklist–Revised (PCL-R) were coded on file information of 78 female forensic psychiatric patients discharged between 1993 and 2012 with a mean follow-up period of 11.8 years from one of four Dutch forensic psychiatric hospitals. Notable was the high rate of mortality (17.9%) and readmission to psychiatric settings (11.5%) after discharge. Official reconviction data could be retrieved from the Ministry of Justice and Security for 71 women. Twenty-four women (33.8%) were reconvicted after discharge, including 13 for violent offenses (18.3%). Overall, predictive validity was moderate for all types of recidivism, but low for violence. The START Vulnerability scores, HCR-20 V3 , and FAM showed the highest predictive accuracy for all recidivism. With respect to violent recidivism, only the START Vulnerability scores and the Clinical scale of the HCR-20 V3 demonstrated significant predictive accuracy.
A Multidisciplinary Patient-Specific Opioid Prescribing and Tapering Protocol Is Associated with a Decrease in Total Opioid Dose Prescribed for Six Weeks After Total Hip Arthroplasty (2019)

Implementation of a patient-specific prescribing and tapering protocol decreases the mean six-week dosage of opioid prescribed by 63% after THA without increasing the refill rate.
Electronic Properties of Cu2–xSe Nanocrystal Thin Films Treated with Short Ligand (S2–, SCN–, and Cl–) Solutions (2016)

To exploit interesting electronic properties of colloidal semiconductor nanocrystals (NCs) in thin film devices, replacement of the original bulky ligands attached on the NC surface to short ones is essential. Here, we investigate the electronic properties of thin films of Cu2–xSe NCs treated chemically with short sulfide (S2–), thiocyanate (SCN–), and chloride (Cl–) ligands that are known to yield superior physical properties compared to the first-generation short ligand systems including amines and thioles. Specifically, the study focuses on the impact of ligand treatment on their direct/indirect bandgap and NIR-localized surface plasmon resonance (LSPR) in the near-IR regime as well as their electrical conductivity and thermoelectric properties. While the application of S2– solution resulted in exchange of the original oleylamine (OAm) on NC surface with S2– ligands, use of SCN– and Cl– solutions only removed the original ligands. The different ligands consistently led a red-shift of the direct and indirect bandgap. The LSPR was also red-shifted after applying solutions with SCN– and Cl– but was blue-shifted after applying solutions with S2–, which we attribute to the formation of sulfur shell on NC surface. Conductivity as high as 442 S/cm and Seebeck coefficient of 13 μV/K could be obtained from the NC films with Cl– and SCN– ligands, respectively. We believe that the understanding on Cu2–xSe NCs will expand the materials library for electronic applications of copper chalcogenide NCs.
Distributed and cloud computing: from parallel processing to the Internet of things (2012)

From the leading minds in the field, Distributed and Cloud Computing is the first modern, up-to-date distributed systems textbook. Starting with an overview of modern distributed models, the book exposes the design principles, systems architecture, and innovative applications of parallel, distributed, and cloud computing systems. It will teach you how to create high-performance, scalable, reliable systems, providing comprehensive coverage of distributed and cloud computing, including: Facilitating management, debugging, migration, and disaster recovery through virtualization Clustered systems for research or ecommerce applications Designing systems as web services Social networking systems using peer-to-peer computing Principles of cloud computing using examples from open-source and commercial applications Using examples from open-source and commercial vendors, the text describes cloud-based systems for research, e-commerce, social networking and more. Complete coverage of modern distributed computing technology including clusters, the grid, service-oriented architecture, massively parallel processors, peer-to-peer networking, and cloud computing Includes case studies from the leading distributed computing vendors: Amazon, Microsoft, Google, and more Designed to meet the needs of students taking a distributed systems course, each chapter includes exercises and further reading, with lecture slides and solutions available online
Metastable States in Pressurized Bulk and Mesoporous Germanium (2018)

Combination of porosity and hydrostaticity during compression is used with a view to explore the energy landscape of germanium. In this work, pressure-induced phase transformations in mesoporous crystalline Ge has been investigated by in situ Raman spectroscopy. A pressure-induced amorphization to a low-density amorphous (LDA) state was observed prior to a reversible polyamorphic transformation between LDA and high-density amorphous states. These pressure-induced transformations show some similarities with the behavior previously reported in nanoparticles. Thermodynamics models developed in the case of nanoparticles are successfully used indicating that, in both cases, the large surface-to-volume ratio leads to an increase of the system energy and that mesoporous materials may be considered as the negative image of a collection of nanoparticles. However, an inhomogeneous stress distribution is expected in porous materials because of it being a network with hyperbolic geometry. A control experiment is presented using a reference bulk germanium sample. The diamond-to-β-tin transformation is observed starting at around 8.0 GPa. On decompression, the metastable ST12 (Ge-III) phase is observed. Ab initio simulations are used to assign and interpret Raman spectra of this phase.
«Los desafíos de la Justicia del siglo XXI»: Documento base del discurso del Ministro de Justicia en la inauguración del Curso de la UIMP «Una justicia de Futuro-2.ª Edición» (2016)

En el marco de las actividades de la Universidad Internacional Menendez Pelayo, tuvo lugar el pasado 11 de julio el curso organizado por el Ministerio de Justicia y patrocinado por Wolters Kluwer, denominado �Una justicia de Futuro�. Reproducimos a continuacion el texto base del discurso del Ministro de Justicia en funciones Rafael Catala, por su interes para nuestros lectores, ya que se trata de un completo y estructurado proyecto para la organizacion de la Administracion de Justicia del Siglo XXI. Parte del diagnostico de los problemas, la descripcion y valoracion de los resultados de las medidas adoptadas hasta el momento y concluye con una propuesta de estrategia basada en el consenso, al que convoca a todos, sobre los 4 ejes siguientes: transparencia, agilidad, definicion de una Justicia para las personas y su transformacion tecnologica.
Evaluation of RAD50 in familial breast cancer predisposition (2005)

The genes predisposing to familial breast cancer are largely unknown, but 5 of the 6 known genes are involved in DNA damage repair. RAD50 is part of a highly conserved complex important in recognising, signalling and repairing DNA double-strand breaks. Recently, a truncating mutation in the RAD50 gene, 687delT, was identified in 2 Finnish breast cancer families. To evaluate the contribution of RAD50 to familial breast cancer, we screened the whole coding region for mutations in 435 UK and 46 Finnish familial breast cancer cases. We identified one truncating mutation, Q350X, in one UK family. We screened a further 544 Finnish familial breast cancer cases and 560 controls for the 687delT mutation, which was present in 3 cases (0.5%) and 1 control (0.2%). Neither Q350X nor 687delT segregated with cancer in the families in which they were identified. Functional analyses suggested that RAD50 687delT is a null allele as there was no detectable expression of the mutant protein. However, the wild-type allele was retained and expressed in breast tumors from mutation carriers. The abundance of the full-length RAD50 protein was reduced in carrier lymphoblastoid cells, suggesting a possible haploinsufficiency mechanism. These data indicate that RAD50 mutations are rare in familial breast cancer and either carry no, or a very small, increased risk of cancer. Altogether, these results suggest RAD50 can only be making a very minor contribution to familial breast cancer predisposition in UK and Finland.
Using adaptive edge technique for detecting microaneurysms in fluorescein angiograms of the ocular fundus (2003)

This paper describes a new digital image-processing algorithm for detecting microaneurysms in fluorescein angiograms of the ocular fundus for diabetic retinopathy patients. Firstly, edges in the image have been detected using the Canny edge detector. Edges which represent vessel segments have been removed from the image. Sobel edge detection is then used for the neighborhoods of the remaining objects. The analysis of size, shape, and energy characteristics of the resultant objects is used to finally segment the microaneurysm from other retinal features. The proposed scheme outperforms currently available techniques in both the sensitivity of microaneurysm detection and the speed of performance.