gebhart/patrepeval huggingface dataset:
Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid. (1985)

Cytochrome P-450j has been purified to electrophoretic homogeneity from isoniazid-treated adult male rats; and this enzyme appears to be a major protein induced in hepatic microsomes after administration of isoniazid, as judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The hemoprotein has a minimum molecular weight of approximately 51,500, and the ferrous-carbonyl complex of cytochrome P-450j has a Soret maximum at 451-452 nm. The oxidized heme iron appears to be predominately in the high spin state as deduced from the Soret maximum at 395 nm. Ethylisocyanide binds to ferrous cytochrome P-450j to yield spectral maxima at approximately 458 and 430 nm with a resultant 458/430 ratio of 0.7 at pH 7.4. Cytochrome P-450j has no measurable catalytic activity for the metabolism of benzo[a]pyrene (3- and 9-hydroxylation), hexobarbital, testosterone, and 5 alpha-androstane-3 alpha,17 beta-diol-3,17-disulfate. Low, but detectable, catalytic activity is obtained for the metabolism of 7-ethoxycoumarin, benzphetamine, p-nitroanisole, zoxazolamine, and 2-hydroxylation of 17 beta-estradiol. In contrast, cytochrome P-450j effectively catalyzes p-hydroxylation of aniline with a turnover of 12.7 nmol/min/nmol cytochrome P-450j. Hydroxyl radical scavengers, Fe-EDTA, superoxide dismutase, and catalase have no effect on aniline p-hydroxylation catalyzed by cytochrome P-450j. Cytochrome P-450j is distinct from nine other rat hepatic microsomal cytochromes P-450 (P-450a-P-450i) previously purified in this laboratory, as well as different isozymes described by other investigators, based on several parameters including minimum molecular weight, spectral properties, and catalytic activity. In Ouchterlony double diffusion plates, antibodies against cytochromes P-450a-P-450f show no cross-reaction with cytochrome P-450j. Structural differences among cytochromes P-450a-P-450j are apparent from the NH2-terminal sequence of cytochrome P-450j, as well as the electrophoretic profiles of proteolytic digests of the hemoproteins.
Cerebral Blood Flow in AIDS- Related Neurotoxoplasmosis: A Preliminary 99mTc-HMPAO SPECT Study (1991)

Cerebral blood flow (CBF) was evaluated by gamma camera 99mTc-HMPAO SPECT in 11 patients with AIDS-related neurotoxoplasmosis and correlated with neurological findings and the results of CT and MRI. Evident CBF abnormalities were observed in all patients with involvement of at least two cerebral lobes. In 10 patients the abnormalities were bilateral and in 8 patients basal ganglia were involved; no specific hypoperfusion pattern was however evident. Focal lesions were found in 7 patients by CT (sensitivity: 63.6%) and in 10 patients by MRI (sensitivity: 90.9%). It may be concluded that neurotoxoplasmosis in AIDS patients is associated with a high prevalence of focal cortical and subcortical hypoperfusion but that the scintigraphic findings are not specific; that HMPAO SPECT may show focal hypoperfusion in patients with normal CT studies and/or non-focal MRI abnormalities; that the hypoperfusion may be more extensive than the corresponding MRI lesion(s) and that it may be present even in areas with normal MRI signals; and that more experience and longitudinal studies are needed to assess the possible impact of HMPAO SPECT on follow-up and therapy monitoring.
Trade-off between source and channel coding for video transmission (2002)

An analytical model of a video transmission system is used to study the impact of its parameters. The optimal trade-off between error resilience using INTRA coding and the channel code rate is determined for given channel parameters by minimizing the expected mean square error at the decoder. It is shown that the results strongly depend on the burstiness of the channel.
SIX BALB/c IgA MYELOMA PROTEINS THAT BIND ß-(1 → 6)-D-GALACTAN (1973)

Six IgA myeloma proteins of BALB/c origin which bind antigens containing beta-(1 --> 6)-D-galactan side chains have been isolated by affinity chromatography on galactoside-BSA-Sepharose columns. Partial amino acid sequences of of the light chains to residue Cys23 and the heavy chains to reside 30 were determined on the automated sequencer. No differences were found among the six V(K) sequences. Among some 50 partial V(K) sequences that have thus far been determined these six chains are the only ones thus far identified in this subgroup; at least 25 V(K) subgroups in the mouse have been identified so far. The heavy chain partial sequences were also very closely related but two differences were found. One protein differed from the other five by having isoleucine instead of leucine at position 5, a second protein differed from the others by having an unidentified amino acid at position 19. Using the highly sensitive inhibition of hemagglutination method it was found that each of the proteins possessed a unique inidividual antigenic determinant.
Shape-Controlled Vapor-Transport Growth of Tellurium Nanowires (2012)

A vapor transport method is employed to synthesize single crystalline tellurium nanowires with tailorable size using tellurium powder in an inert atmosphere. The average nanowire diameter is tunable between 50 and 3000 nm with an associated length of 1 to 22 μm. Growth temperature and time are used to specifically control the behavior of supersaturation, leading to nucleation and morphological control in this vapor–solid growth regime. Analysis of the resulting nanowire product provides insight into the dominant reaction kinetics involved in these growths and suggests routes by which to control growth product. This methodology provides a practical approach to synthesizing high-quality tellurium nanowires of various sizes and their incorporation into two-dimensional mesh-like structures through controlled nucleation and growth dynamics.
Effect of Plant Phenolics on Protein and Lipid Oxidation in Cooked Pork Meat Patties (2005)

Rapeseed and pine bark are rich sources of phenolic compounds that have in previous studies been shown to exhibit antioxidant and anti-inflammatory properties. In this study, the antioxidant effect of rapeseed and pine bark phenolics in inhibiting the oxidation of lipids and proteins in meat was tested as a possible functional food application. The cooked pork meat with added plant material was oxidized for 9 days at 5 degrees C under light. The suitable level of plant material addition was first screened by following lipid oxidation only. For further investigations plant materials were added at a level preventing lipid oxidation by >80%. The oxidation was followed by measuring the formation of hexanal by headspace gas chromatography and the formation of protein carbonyls by converting them to 2,4-dinitrophenylhydrazones and measured by spectrophotometer. It was shown that rapeseed and pine bark were excellent antioxidants toward protein oxidation (inhibitions between 42 and 64%). These results indicate that rapeseed and pine bark could be potential sources of antioxidants in meat products.
A Study on the Kinetics and Mechanism of the Hydrolysis of Dihydro-1,4-oxathiin Derivatives (1996)

The kinetics of the hydrolysis of dihydro-1, 4-oxathiin derivatives were investigated by ultraviolet spectrophotometry in H2O at A rate equation which can be applied over a wide pH range was obtained. The substituent effects on the hydrolysis of dihydro-1, 4-oxathiin derivatives were studied and the rate of hydrolysis was shown to be accelerated by electron accepting groups. Final product of the hydrolysis was 2-(2-hydroxyethylthio)acetoacet-anilide enol form. On the basis of rate equations derived and judging from hydrolysis products obtained and from general base effect and substituent effects, plausible mechanism of the hydrolysis in various pH range have been proposed. Below pH 3.5, the hydrolysis was initiated by the protonation and followed by the addition of water to 2-carbon. Above pH 10.0, the hydrolysis was proceeded by the addition of hydroxide to 2-carbon. In the range of pH 4.0∼10.0, the addition of water to dihydro-1,4-oxathiin is rate controlling step.
Mathematical Model For Deposition Of Soot (1991)

Semiempirical mathematical model predicts deposition of soot in tubular gas generator in which hydrocarbon fuel burned in very-fuel-rich mixture with pure oxygen. Developed in response to concern over deposition of soot in gas generators and turbomachinery of rocket engines. Also of interest in terrestrial applications involving fuel-rich combustion or analogous process; e.g., purposeful deposition of soot to manufacture carbon black pigments.
Basic models and questions in statistical network analysis (2017)

Extracting information from large graphs has become an important statistical problem since network data is now common in various fields. In this minicourse we will investigate the most natural statistical questions for three canonical probabilistic models of networks: (i) community detection in the stochastic block model, (ii) finding the embedding of a random geometric graph, and (iii) finding the original vertex in a preferential attachment tree. Along the way we will cover many interesting topics in probability theory such as Pólya urns, large deviation theory, concentration of measure in high dimension, entropic central limit theorems, and more.
Inside–outside OH– incursion involved in the fabrication of hierarchical nanoflake assembled three-dimensional flower-like α-Co(OH)2 for use in high-performance aqueous symmetric supercapacitor applications (2022)

Solvothermally-synthesized, optimized HN-3DF-α-Co(OH)<sub>2</sub> showed outstanding electrochemical performance results in three- and two-electrode systems. This unique aqueous symmetric supercapacitor can be used to design cost-effective symmetric capacitors based on metal hydroxide.
A horse or a zebra? Unusual manifestations of common cutaneous infections in primary immunodeficiency pediatric patients (2023)

Background Patients with primary immunodeficiency disorders (PIDs) often suffer from recurrent infections because of their inappropriate immune response to both common and less common pathogens. These patients may present with unique and severe cutaneous infectious manifestations that are not common in healthy individuals and may be more challenging to diagnose and treat. Objective To describe a cohort of patients with PIDs with atypical presentations of skin infections, who posed a diagnostic and/or therapeutic challenge. Methods This is a retrospective study of pediatric patients with PID with atypical presentations of infections, who were treated at the immunodeficiency specialty clinic and the pediatric dermatology clinic at the Sheba Medical Center between September 2012 and August 2022. Epidemiologic data, PID diagnosis, infectious etiology, presentation, course, and treatment were recorded. Results Eight children with a diagnosis of PID were included, five of whom were boys. The average age at PID diagnosis was 1.7 (±SD 3.2) years. The average age of cutaneous infection was 6.9 (±SD 5.9) years. Three patients were born to consanguineous parents. The PIDs included the following: common variable immunodeficiency, severe combined immunodeficiency, DOCK8 deficiency, ataxia telangiectasia, CARD11 deficiency, MALT1 deficiency, chronic granulomatous disease, and a combined cellular and humoral immunodeficiency syndrome of unknown etiology. The infections included the following: ulcerative-hemorrhagic varicella-zoster virus (two cases) atypical fungal and bacterial infections, resistant Norwegian scabies, giant perianal verrucae (two cases), and diffuse molluscum contagiosum. Conclusions In this case series, we present unusual manifestations of infectious skin diseases in pediatric patients with PID. In some of the cases, recognition of the infectious process prompted life-saving treatment. Increasing familiarity with these dermatological manifestations, as well as keeping a high index of suspicion, is important to enabling early diagnosis of cutaneous infections in PIDs and initiation of prompt suitable treatment.
Design of a framework for enabling TSN support in heterogeneous platforms with virtualization and preliminary experimental results (2021)

The increasing complexity of modern applications calls for more complex embedded computing resources, which integrate several processing units with specialized hardware and virtualization support on a single platform to boost the computation capabilities. These subsystems require a communication system able to support different flows with diverse real-time requirements. In this context, the Time-Sensitive Networking (TSN) family of standards plays an important role. This work proposes the design and the implementation of a framework for enabling TSN communications in heterogeneous platforms with virtualization. Preliminary experimental results are reported, which provide some insights on the limitations and advantages of the proposed framework.
Deep Learning for Edge Computing: Current Trends, Cross-Layer Optimizations, and Open Research Challenges (2019)

In the Machine Learning era, Deep Neural Networks (DNNs) have taken the spotlight, due to their unmatchable performance in several applications, such as image processing, computer vision, and natural language processing. However, as DNNs grow in their complexity, their associated energy consumption becomes a challenging problem. Such challenge heightens for edge computing, where the computing devices are resource-constrained while operating on limited energy budget. Therefore, specialized optimizations for deep learning have to be performed at both software and hardware levels. In this paper, we comprehensively survey the current trends of such optimizations and discuss key open research mid-term and long-term challenges.
C-Reactive Protein—Undervalued, Underutilized (1997)

Tissue injury or infection leads to an increase in the serum concentration of a number of analytes, and to a decrease in the serum concentration of several others (1)(2). The change in concentration is referred to as the acute-phase response. Serum analytes that increase in concentration include C-reactive protein (CRP), serum amyloid A, fibrinogen, haptoglobin, ceruloplasmin, copper, interleukin-6, polypeptide-specific antigen, neopterin, and ferritin (3)(4)(5)(6). Analytes that decrease in concentration include transferrin and iron (6).

CRP is a noteworthy member of this group because of the speed and degree to which its concentration increases after a variety of inflammatory states or injuries to tissues—including myocardial injury or infarction (2). CRP was discovered in 1930 by William Tillet and Thomas Francis at the Rockefeller Institute (7). They extracted a protein from the sera of patients with pneumococcal pneumonia that coprecipitated with the C polysaccharide derived from the cell wall of the pneumococcus. Because the reaction between the protein and the polysaccharide was so specific they named the protein C-reactive protein.

The original test was a simple precipitin test, usually in …
Information Theoretic Analysis of Production-Perception Efficiency: Case Study of Speech Pathology (2016)

LIDIAP
A Novel Dual Full-Bridge LLC Resonant Converter for CC and CV Charges of Batteries for Electric Vehicles (2017)

This paper introduces a novel concept for implementing constant current (CC) and constant voltage (CV) charges of batteries for electric vehicles using a dual full-bridge LLC (FBLLC) resonant converter, which shares its primary switches. In the proposed concept, the CC and CV charges are implemented using the inherent characteristics of an LLC converter as a current source and a voltage source. One FBLLC resonant converter operates with a fixed-resonant network whereas the other operates with a variable resonant network for the CC and CV charge operations. The proposed converter can achieve zero voltage switching (ZVS) and nearly zero current switching (ZCS) for all of the primary switches in the CC charge operation, and ZVS for all of the primary switches in the CV charge operation, which lead to a high efficiency. In addition, fixed switching frequency operation is possible in both the CC and CV charges thanks to the variable resonant network. A 3.3-kW prototype converter is implemented to verify the feasibility and validity of the proposed converter and a maximum efficiency of 98% was achieved.
A 24-GHz 90-nm CMOS beamforming receiver front-end with analog baseband phase rotation (2010)

A 24 GHz 2-path beamforming receiver front-end in 90 nm CMOS is presented. It consists of two direct conversion front-ends followed by a baseband block performing phase rotation and signal combination. The baseband phase rotation is performed by combining the quadrature phases using digitally controlled weights, achieving a phase resolution of 11 degrees. From each of the two inputs the front-end measures; a conversion gain of 13 dB, NF <; 9 dB, ICP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1db</sub> = -20.5dBm, IIP3 = -7.5dBm, LO-RF isolation 48dB, all at a power consumption of 33.6mW from a 1.2 V supply. The chip area is 1400 × 850 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , including pads, of which the phase rotation block occupies 400 × 100 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
A First Principles Density Functional Study of Crystalline FOX‐7 Chemical Decomposition Process under External Pressure (2006)

Abstract We report on a first principles analysis of chemical decomposition reaction in a crystalline FOX‐7 (1,1‐diamino‐2,2‐dinitroethylene) molecule, which is a good candidate for insensitive energetic materials. Our calculations are based on variable‐cell shape methods under pressure, density functional theory with localized numerical orbital and pseudopotential, together with ab initio biasing molecular dynamics. The calculated crystal structure and equation of state (pressure vs. volume) up to 8 GPa agrees well with the corresponding experimental data. A chemical decomposition by intermolecular hydrogen transfer is found at higher pressure. This decomposition appears to be driven by a weakening in the chemical hardness. This suggests that the molecular HOMO and LUMO orbital energy difference is decreased when intermolecular hydrogen transfers occur, and for the FOX‐7 crystal the band gap is narrowed with increasing external pressure.
Manufacturing cost relationships for vacuum bag-only prepreg processing (2015)

Vacuum bag-only prepregs enable the out-of-autoclave manufacture of high-performance composite structures and increase the material, part, and process selection space. However, manufacturing choices involve economic as well as technical considerations. To understand these relationships, we developed a technical cost model that captures the distinctive characteristics of vacuum bag-only prepreg processing (including vacuum-induced air evacuation and resin cure) and estimates the costs associated with materials, equipment, and labor. We applied the model to realistic manufacturing cases and used a parametric study to evaluate the effects of part characteristics, material use efficiency, and cure efficiency. The results indicate that prepreg cost, part size, prepreg waste, and the air evacuation capacity of the material have the strongest influence on part costs and demonstrate that cost modeling can guide efforts to improve or optimize processing by identifying the most economically valuable modifications.
Effect of hemorrhage rate on early hemodynamic responses in conscious sheep (2016)

Physiological compensatory mechanisms can mask the extent of hemorrhage in conscious mammals, which can be further complicated by individual tolerance and variations in hemorrhage onset and duration. We assessed the effect of hemorrhage rate on tolerance and early physiologic responses to hemorrhage in conscious sheep. Eight Merino ewes (37.4 ± 1.1 kg) were subjected to fast (1.25 mL/kg/min) and slow (0.25 mL/kg/min) hemorrhages separated by at least 3 days. Blood was withdrawn until a drop in mean arterial pressure (MAP) of >30 mmHg and returned at the end of the experiment. Continuous monitoring includedMAP, central venous pressure, pulmonary artery pressure, pulse oximetry, and tissue oximetry. Cardiac output by thermodilution and arterial blood samples were also measured. The effects of fast versus slow hemorrhage rates were compared for total volume of blood removed and stoppage time (whenMAP < 30 mmHg of baseline) and physiological responses during and after the hemorrhage. Estimated blood volume removed whenMAPdropped 30 mmHg was 27.0 ± 4.2% (mean ± standard error) in the slow and 27.3 ± 3.2% in the fast hemorrhage (P = 0.47, pairedttest between rates). Pressure and tissue oximetry responses were similar between hemorrhage rates. Heart rate increased at earlier levels of blood loss during the fast hemorrhage, but hemorrhage rate was not a significant factor for individual hemorrhage tolerance or hemodynamic responses. In 5/16 hemorrhages MAP stopping criteria was reached with <25% of blood volume removed. This study presents the physiological responses leading up to a significant drop in blood pressure in a large conscious animal model and how they are altered by the rate of hemorrhage.
ChemInform Abstract: Asymmetric Induction in the (2 + 2)Cycloaddition of a Keteniminium Salt: An Approach to Chiral 13‐Oxa Prostanoids. (1988)

Abstract The ether (III) which is prepared from (I) reacts with sBuLi, ZnCl 2 , and the aldehyde (IV) to give the adducts (V).
Ion Exchange Characteristics of Novel HDBPDA and Dowex Ion Exchange Resins (1993)

HDBPDA ion exchange resin, {(4, 5) : (13, 14)-Dibenzo-6, 9, 12-trioxa-3, 15, 21, -triazabicyclo [15. 3. 1]heneicosa-(1, 17, 19)(18, 20, 21) triene ion exchange resin : HDBPDA ion exchange resin} had a capacity of 3.8meq/g dry resin. The distribution coefficients of alkali and alkaline earth metal ions on HDBPDA and strongly acidic cation exchange resin, Dowex 50W-X8(200-400mesh) in water, and the various concentrations of hydrochloric acid were determined. Concentration of hydrochloric acid have almost not influenced on the distribution coefficients of alkali and alkaline earth metal ions for the HDBPDA ion exchange resin, but generally the distribution coefficient slightly increased with decreasing concentration of hydrochloric acid. The distribution coefficients of metal ions in water are larger than those in various hydrochloric acid concentration. The distribution coefficients of alkali and alkaline earth metal ions for the Dowex 50W-X8 ion exchange resin increased with decreasing hydrochloric acid concentration. Especially, the distribution coefficients of alkaline earth metal ions increased rapidly compared to those for alkali metal ions. The distribution coefficients of alkali and alkaline earth metal ions on HDBPDA ion exchange resin increased in a linear manner with decreasing acid concentration, and the slope, d log Kd/d log is about -0.2. Of the distribution cofficients of alkali metal ions on Dowex 50W-X8, at range of moderate hydrochloric acid concentration, the slope is about -1, while the slope for alkaline earth metal ions is about -2. However, at very low hydrochloric acid concentration, the linear variation between distribution coefficient and acid concentration was not occurred, but the slope was deviated from above values at low acid concentration.