gebhart/patrepeval huggingface dataset:
Offline constraint screening for online mixed-integer optimization. (2021)

Mixed Integer Linear Programs (MILP) are well known to be NP-hard problems in general, and therefore, tackling and using their solution in online applications is a great challenge. Some Machine Learning techniques have been proposed in the literature to alleviate their computational burden. Unfortunately, these techniques report that a non-negligible percentage of the resulting machine-learning-based solutions are infeasible. 
By linking Mathematical Optimization and Machine Learning, this paper proposes an offline-online strategy to solve MILPs in a fast and reliable manner. The offline step seeks to identify the so-called support constraints of past instances of the target MILP and uses them to train a Machine Learning model of our choice. This model is subsequently used online to generate a reduced MILP that is significantly easier to solve. 
Through synthetic and real-life MILPs, we show that our approach dramatically decreases the risk of obtaining solutions from the reduced MILP that are infeasible in the original formulation without any extra cost in terms of computational time. Hence, our methodology is appropriate for online applications where feasibility is of particular importance.
Direct suppression of lymphocyte induction by the immunoregulatory human serum low density lipoprotein, LDL-In. (1980)

Preparations of LDL-In, an immunosuppressive lipoprotein subfraction, were analyzed for the capacity to directly suppress the response of human lymphocytes to the representative stimulant PHA vis-a-vis indirect mechanisms mediated by soluble factors or cell:cell interactions. Serum lipoprotein subfraction enriched in LDL-In induced a suppressed state in lymphocytes during 18-hr induction cultures. These lymphocytes, whether partially or completely suppressed, when added to fresh responder lymphocytes in the presence of PHA did not suppress the response of the responder lymphocytes. In contrast, the major low density lipoprotein (LDL) did not suppress lymphocytes at equivalent concentration in the induction culture, nor did LDL-exposed lymphocytes suppress responder lymphocytes. The supernatant medium from LDL-In-suppressed lymphocytes did not contain a newly synthesized or released suppressive factor. Finally, LDL-In-suppressed lymphocytes were not rescued by normal lymphocytes. Each of these observations, and previous evidence that adherent cells do not mediate the biologic effects of LDL-In, support the hypothesis that the biologic manifestations of LDL-In suppression of lymphocyte function result from a direct effect on the lymphocyte that is exposed to this lipoprotein, possibly via the previously demonstrated LDL-In receptor.
Dynamics of Quasi-One-Dimensional Structures under Roughening Transition Stimulated by External Irradiation (2022)

We studied the striking effect of external irradiation of nanowires on the dynamics of their surface morphology at elevated temperatures that do not destroy their crystal lattice. Numerical experiments performed on the basis of the Monte Carlo model revealed new possibilities for controlled periodic modulation of the cross-section of quasi-one-dimensional nanostructures for opto- and nanoelectronic elements. These are related to the fact that external irradiation stimulates the surface diffusion of atoms. On the one hand, such stimulation should accelerate the development of the well-known spontaneous thermal instability of nanowires (Rayleigh instability), which leads to their disintegration into nanoclusters. On the other hand, this leads to the forced development of the well-known roughening transition (RT) effect. Under normal circumstances, this manifests itself on selected crystal faces at a temperature above the critical one. The artificial stimulation of this effect on the lateral surface of quasi-one-dimensional structures determines many unpredictable scenarios of their surface dynamics, which essentially depend on the orientation of the nanowire axis relative to its internal crystal structure. In particular, the long-wave Rayleigh breakup observed in absence of external irradiation transforms into strongly pronounced short-wave metastable modulations of the cross-section (a chain of unduloids). The effect of the self-consistent relationship between the Rayleigh instability and RT is dimensional and can be observed only at relatively small nanowire radii. The fact is analyzed that, for the manifestation of this effect, it is very important to prevent significant heating of the nanowire when surface diffusion is stimulated. A number of developed theoretical concepts have already found confirmation in real experiments with Au and Ag nanowires irradiated by electrons and Ag<sup>+</sup> ions, respectively.
Generation of dendritic cell-based vaccines for cancer therapy (2002)

Dendritic cells play a major role in the generation of immunity against tumour cells. They can be grown under various culture conditions, which influence the phenotypical and functional properties of dendritic cells and thereby the consecutive immune response mainly executed by T cells. Here we discuss various conditions, which are important during generation and administration of dendritic cells to elicit a tumouricidal T cell-based immune response.
In-situ combustion diagnostics using diode laser absorption sensors (2001)

The availability of extended wavelength DFB diode lasers makesin-situ flame measurements of important combustion species such as CO2 possible. This work presents recent measurements near 2µm of CO2 concentration above flat-flame burners.
A divergent gene family encoding candidate olfactory receptors of the moth Heliothis virescens (2002)

The antennae of moths have been an invaluable model for studying the principles of odour perception. In spite of the enormous progress in understanding olfaction on the molecular level, for the moth one of the key elements in olfactory signalling, the odourant receptors, are still elusive. We have assessed a genome database of a heliothine moth (Heliothis virescens, Noctuidae) and employed exon-specific probes to screen an antennal cDNA library of this species. Analysis of isolated cDNA-clones led to the discovery of a divergent gene family encoding putative seven-transmembrane domain proteins. The notion that they may encode candidate olfactory receptors of the moth, was supported by a tissue-specific expression; several of the subtypes were exclusively expressed in antennae. By means of double-labelling in situ hybridization studies it was demonstrated that the receptors are indeed expressed in antennal sensory neurons; moreover, each receptor subtype appears to be expressed in a distinct population of sensory cells. The results strongly suggest that the newly discovered gene family indeed encodes olfactory receptors of moth.
Integration of a Technology-Based Mental Health Screening Program Into Routine Practices of Primary Health Care Services in Peru (The Allillanchu Project): Development and Implementation (2018)

The use of a screening app supported by training and supervision is feasible and uncovers a high prevalence of unidentified psychological symptoms in primary care. To increase its sustainability and utility, this procedure can be incorporated into the routine practices of existing health care services, following tailoring to the resources and features of each service. The early detection of psychological symptoms by a PHCP within a regular consultation, followed by adequate advice and support, can lead to a significant percentage of patients accessing specialized care and reducing the treatment gap of mental disorders.
Perfluorochemical Emulsion Oxygen Transport Fluids: A Clinical Review (1985)

Perfluorochemical liquids are inert, immiscible in water, and have approximately 20 times the solubility for oxygen and carbon dioxide as does water. When emulsified in a normal saline solution, they can act as an oxygen-transporting resuscitation fluid. Fluosol-DA 20% is the first perfluorochemical emulsion to be studied clinically. It can supplement oxygen transport in anemic patients, but no control study has as yet determined its clinical effectiveness.
Evaluation of IDEALSmile for 90-nm FLASH memory contact holes imaging with ArF scanner (2004)

According to sizes dictated by ITRS road map, contact holes are one of the most challenging features to be printed in the semiconductor manufacturing process. The development of 90[nm] technology FLASH memories requires a robust solution for printing contact holes down to 100[nm] on 200[nm] pitch. The delay of NGL development as well as open issues related to 157[nm] scanner introduction pushes the industry to find a solution for printing such tight features using existing ArF scanner. IDEALSmile technology from Canon was proven to be a good candidate for achieving such high resolution with sufficiently large through pitch process window using a binary mask, relatively simple to be manufactured, with a modified illumination and single exposure, with no impact on throughput and without any increase of cost of ownership. This paper analyses main issues related to the introduction of this new resolution enhancement technology on a real FLASH memory device, highlighting advantages as well as known problems still under investigation.
FOREIGN INTERNS AND RESIDENTS IN THE UNITED STATES, 1956-1957 (1957)

A total of 6,741 foreign physicians from 88 countries were reported as interns or residents during a survey of 1,242 hospitals of the United States during the year 1956-1957. Of these, 4,753 were residents, 1,988 were interns, 1,673 were working in the state of New York, 1,332 came from the Philippine Islands, and 908 were women. The gross totals for four successive years beginning with 1953-1954 have been 2,920; 5,036; 6,033; and 6,741. This steady increase is matched by a steady increase in the number of hospitals reporting foreign residents and interns, but the proportions of physicians coming from various countries, their distribution among the various specialties, and also their distribution among the various states of the union have remained comparatively constant.
A phase I dose-escalation study of eribulin and S-1 for metastatic breast cancer (2015)

Dose level 3 was not tolerated owing to febrile neutropenia development. Thus, intermediate dose level 2 was recommended for further evaluation. Preliminary antitumour activity warrants further investigation in this setting.
1,25-Dihydroxyvitamin D3 Corrects Bone Loss But Suppresses Bone Remodeling in Ovariohysterectomized Beagle Dogs* (1988)

The decrease in intestinal calcium absorption and lower blood levels of 1,25-dihydroxyvitamin D [1,25-(OH)2D3] have been implicated in the pathogenesis of postmenopausal osteoporosis. This study evaluates the effects on bone of 1,25-(OH)2D3 therapy using the ovariohysterectomized dog model. The cessation of ovarian function was ascertained by an increase in serum LH levels 4 weeks after ovariohysterectomy, and significant bone loss was revealed four months after ovariohysterectomy. The bone loss was associated with an increase in the number of bone-forming cells and a decrease in the activity of these cells. The administration of 1,25-(OH)2D3 increased the activity of the bone cells and resulted in a reversal of all abnormalities in structural parameters of bone, including cancellous bone mass, trabecular wall thickness, trabecular plate separation, trabecular plate density, and trabecular plate thickness (which increased above normal). However, 1,25-(OH)2D3 therapy was also associated with a significant decrease in the number of bone-forming cells, resulting in lower bone formation at the tissue level. The results of this study indicate that 1,25-(OH)2D3 therapy can reverse the bone loss and osteoblastic insufficiency responsible for the maintenance of negative bone balance after the cessation of ovarian function. However, this therapy has a suppressive effect on bone cell number and bone turnover. This undesired side-effect of 1,25-(OH)2D3 therapy renders a chronic therapeutic regimen inefficient for the long term management of patients with osteoporosis. Intermittent 1,25-(OH)2D3 therapy or a sequential therapy using 1,25-(OH)2D3 along with substances known to increase the number of bone-forming cells is strongly suggested by these results.
Semiconductor nanowires for efficient, sustainable solar energy harvesting (2013)

LMSC1
Answer-set programming with bounded treewidth (2009)

In this paper, we present a novel approach to the evaluation of propositional answer-set programs. In particular, for programs with bounded treewidth, our algorithm is capable of (i) computing the number of answer sets in linear time and (ii) enumerating all answer sets with linear delay. Our algorithm relies on dynamic programming. Therefore, our approach significantly differs from standard ASP systems which implement techniques stemming from SAT or CSP, and thus usually do not exploit fixed parameter properties of the programs. We provide first experimental results which underline that, for programs with low treewidth, even a prototypical implementation is competitive compared to state-of-the-art systems.
Дополнительные критерии оценки состояния здоровья доноров аппаратного тромбоцитафереза (2014)

Search for additional criteria for evaluating the health status of donors for plateletapheresis (PA) was carried out. The effects of PA on blood biochemistry, erythropoiesis, and rheology were carried out by Density-specific distribution of erythrocytes (DSDE) method and the clotting system status was evaluated by endogenous thrombin potential (ETP) registration. Platelet donors exhibited folic acid deficit, associated with increase of homocysteine level, associated with liability to thrombophilia. Study of blood rheology by ETP registration showed that repeated PA procedures did not impair the barrier characteristics of erythrocyte membrane. Studies of hemostasis with ETP evaluation showed no appreciable shifts, while the detected trend to hypocoagulation (5.7% decrease) after PA was caused by the anticoagulant. Studies of platelet reduction after PA detected the reserve potentials of donors (platelet counts reduced to 184.7 ± 7.7 • 10 9/l). Conclusion. Substantial inspection of donors for repeated PA for identification latent anemias and a throm-bophilia is necessary.
Fine Structure of Three Different Anti-Fluorescein Combining Sites: Induced Circular Dichroism of Hapten Bound to Autologous and Heterologous Recombinants (1976)

Abstract We have previously reported the sequential appearance in hyperimmunized rabbits of three distinct types of antifluorescein-combining sites that can be distinguished by the characteristic induced circular dichroism (CD) of the bound hapten, fluorescein. Such induced CD depends on the configuration of the surrounding residues, and, in the case of anti-fluorescein, can be localized to the configuration of the sub-site which binds the hydroxyxanthenone moiety of fluorescein. In the present investigation, we have studied the fine structure of both autologous and heterologous recombinant sites and of the free chains by measuring the induced CD of bound hapten. Heavy chain dimers at pH 5.4 bound fluorescein that displayed a weak negative CD band which is different from that observed in any of the native antibodies. No induced CD was observed with light chains. Thus, the hydroxyxanthenone subsite does not exist intact in any of the isolated chains. Fluorescein bound to purified autologous recombinants, when studied at pH 7.5, exhibited CD spectra very similar to those observed for the original antibodies. Most significantly, fluorescein bound to purified heterologous recombinants, prepared in all possible combinations, showed CD spectra most similar to those exhibited by sites from which the heavy chain was derived. Thus, the microenvironment of the subsite appears to be due primarily to the heavy chain.
Co-occurrence of cyanogenic glucosides and their derivatives as a common feature in metabolic profiles of almond and cassava (2014)

Almond (Prunus dulcis L.) and cassava (Manihot esculenta Crantz) are two important food crops and representatives of more than 2600 plants species known to produce amino acid-derived cyanogenic glucosides. Cyanogenic glucosides function as effective phytoanticipins, responsible for a sophisticated defence mechanism: the release of toxic HCN (cyanogenesis) upon tissue disruption [1]. However, cyanogenic glucosides are not only stagnant defence compounds. Increasing evidence points towards a dynamic endogenous turnover to provide plant primary metabolism with a supply of reduced nitrogen [2 – 4]. In order to investigate the presence of putative turnover products of cyanogenic glucosides, metabolite profiling using LC-MS/MS and HR-MS has been carried out in almond and cassava. In total, 21 structural derivatives of the aromatic cyanogenic glucosides prunasin and amygdalin in almond, and of the aliphatic cyanogenic glucosides linamarin and lotaustralin in cassava, have been identified, including di- and triglucosides and apiosides derived from a number of the aforementioned compounds. The relative amounts of the compounds were determined in different tissues and at various developmental stages.
P4‐241: Novel TARDBP mutation associated with frontotemporal dementia and movement disorder but not motor neuron disease (2009)

TDP-43 has been identified as the pathological protein in the majority of cases of frontotemporal lobar degeneration and amyotrophic lateral sclerosis (ALS). Mutations in the TARDBP gene, located on chromosome 1p36 and encoding TDP-43, have been associated with both sporadic and familial ALS but not with frontotemporal dementia. Clinical evaluation, neuropathology, genetic analysis of TARDBP, Progranulin (PGRN), Huntingtin (HTT) genes. A 35-years-old man developed frontotemporal dementia, supranuclear palsy and chorea, in absence of signs of motor neuron disease. Neuropathologic examination revealed phospho-TDP-43-immunoreactive deposits in neuronal cytoplasm and nuclei as well as in glial, predominantly seen in the caudate nucleus, putamen and brainstem nuclei. Genetic analysis revealed an adenine to guanine substitution at position one of codon 263 (exon 6) in one allele of the proband's TARDBP gene. This mutation results in a glutamate for lysine (K263E) change. No mutations in PGRN and HTT genes were found. The number of HTT trinucleotide repeats was in the range of normal controls. Since clinical information on the proband's family was limited and no DNA from relatives was available, we were not able to prove the segregation of this mutation with the disease. Our observation suggests that TARDBP mutations may be associated with a clinicopathologic spectrum of disorders wider than familial and sporadic ALS, and supports the utility of TARDBP genetic testing of all cases of atypical FTD. This study is partly supported by EU Grant FP6, BNEII No LSHM-CT-2004-503039, NIH AG 010133 and University of Siena, Italy.
Microwave Ablation for Hepatic Malignancies (2013)

In this large data set, patients with 3 cm or more tumors showed a propensity for early recurrence, regardless of histology. Higher rates of local recurrence were noted in HCC patients, which may reflect underlying liver disease. There were no significant differences in morbidity or survival based on the surgical approach; however, local recurrence rates were highest for percutaneously ablated tumors.
Figment: Fine-grained Permission Management for Mobile Apps (2019)

Today's Android systems do not allow users to manage the permissions granted to applications (apps) in a flexible and dynamic way. Recent studies show that apps often misuse these permissions to access private information, or have trapdoors via which other malicious apps can do the same. In this paper, we develop a framework Figment, which consists of set of libraries that developers can easily use to build in fine-grained dynamic permission management capabilities. The users of their apps can readily invoke these capabilities during execution. The apps would potentially run with reduced functionalities if the user does not wish to allow certain permissions. Figment also allows either the developer or a user to specify context aware permissions, which cause different permissions to be granted to the app in different functional modes (contexts). We believe that Figment reduces the attack surface exposed to potentially malicious apps and offers a significant step in preserving user privacy. While the rudimentary version of Figment uses aspect-oriented programming and does not need rooting of the phone or changes to the Android sub-system, we also provide an optional root-level fail safe implementation that facilitates the embedding of dynamic permission management functions in old applications not built by using Figment libraries. We show that Figment offers significant benefits over the Android Marshmallow permission management system with lower runtime overheads; the main penalty is a one time higher compilation overhead.
Utility of EUS following endoscopic polypectomy of high-risk rectosigmoid lesions (2015)

Following endoscopic polypectomy of high-risk rectal neoplasia, the incremental yield of EUS compared with WLE/BX for evaluation of residual disease appears limited, especially in patients with benign disease.
Terra de Deus e propriedade privada: os cristãos e a propriedade na Igreja Antiga (1983)

Em 1982 a IECLB dedicou-se ao estudo do tema: Terra de Deus - Terra para todos. Na Faculdade de Teologia o tema foi debatido em um Ciclo de Palestras. O estudo aqui apresentado evidencia a importância do estudo dos textos dos pais da Igreja para temas atuais.
Application of dynamic logistic regression with unscented Kalman filter in predictive coding (2017)

Predictive coding, adapted from text categorization for litigation support, is an evolving process with identification of responsive documents and changing labeling decisions. The current state-of-art within predictive coding workflow uses Active Learning, where a new model is periodically rebuilt with additional documents reviewed, to continuously revise a model and improve the identification of responsive documents. We propose an alternative approach to recursively update the model using the Unscented Kalman Filter for each additional labeled document. With synthetic text streaming data and induced concept drift, we show that our approach learns new patterns at a faster rate, renders better accuracy and recall, and requires a reduced labeling cost, which when combined makes it potentially a better alternative in updating the model in the setting of Active Learning for predictive coding.
Mechanical Properties of Zr-Added Fe-Al Intermetallic Alloys Containing Large Second Phase Particles (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.