gebhart/patrepeval huggingface dataset:
Fractality and a Wavelet-Chaos-Neural Network Methodology for EEG-Based Diagnosis of Autistic Spectrum Disorder (2010)

A method is presented for investigation of EEG of children with autistic spectrum disorder using complexity and chaos theory with the goal of discovering a nonlinear feature space. Fractal Dimension is proposed for investigation of complexity and dynamical changes in autistic spectrum disorder in brain. Two methods are investigated for computation of fractal dimension: Higuchi's Fractal Dimension and Katz's Fractal Dimension. A wavelet-chaos-neural network methodology is presented for automated EEG-based diagnosis of autistic spectrum disorder. The model is tested on a database of eyes-closed EEG data obtained from two groups: nine autistic spectrum disorder children, 6 to 13 years old, and eight non-autistic spectrum disorder children, 7 to 13 years old. Using a radial basis function classifier, an accuracy of 90% was achieved based on the most significant features discovered via analysis of variation statistical test, which are three Katz's Fractal Dimensions in delta (of loci Fp2 and C3) and gamma (of locus T6) EEG sub-bands with P < 0.001.
On learning linear functions from subset and its applications in quantum computing (2018)

Let F_{q} be the finite field of size q and let l: F_{q}^{n} -> F_{q} be a linear function. We introduce the Learning From Subset problem LFS(q,n,d) of learning l, given samples u in F_{q}^{n} from a special distribution depending on l: the probability of sampling u is a function of l(u) and is non zero for at most d values of l(u). We provide a randomized algorithm for LFS(q,n,d) with sample complexity (n+d)^{O(d)} and running time polynomial in log q and (n+d)^{O(d)}. Our algorithm generalizes and improves upon previous results [Friedl et al., 2014; Gabor Ivanyos, 2008] that had provided algorithms for LFS(q,n,q-1) with running time (n+q)^{O(q)}. We further present applications of our result to the Hidden Multiple Shift problem HMS(q,n,r) in quantum computation where the goal is to determine the hidden shift s given oracle access to r shifted copies of an injective function f: Z_{q}^{n} -> {0, 1}^{l}, that is we can make queries of the form f_{s}(x,h) = f(x-hs) where h can assume r possible values. We reduce HMS(q,n,r) to LFS(q,n, q-r+1) to obtain a polynomial time algorithm for HMS(q,n,r) when q=n^{O(1)} is prime and q-r=O(1). The best known algorithms [Andrew M. Childs and Wim van Dam, 2007; Friedl et al., 2014] for HMS(q,n,r) with these parameters require exponential time.
An <em>in vivo</em> Crosslinking Approach to Isolate Protein Complexes From <em>Drosophila</em> Embryos (2014)

Many cellular processes are controlled by multisubunit protein complexes. Frequently these complexes form transiently and require native environment to assemble. Therefore, to identify these functional protein complexes, it is important to stabilize them in vivo before cell lysis and subsequent purification. Here we describe a method used to isolate large bona fide protein complexes from Drosophila embryos. This method is based on embryo permeabilization and stabilization of the complexes inside the embryos by in vivo crosslinking using a low concentration of formaldehyde, which can easily cross the cell membrane. Subsequently, the protein complex of interest is immunopurified followed by gel purification and analyzed by mass spectrometry. We illustrate this method using purification of a Tudor protein complex, which is essential for germline development. Tudor is a large protein, which contains multiple Tudor domains - small modules that interact with methylated arginines or lysines of target proteins. This method can be adapted for isolation of native protein complexes from different organisms and tissues.
Substance P-containing neurons of the avian suprachiasmatic nucleus project directly to the nucleus of Edinger-Westphal. (1982)

Retrograde and anterograde pathway tracing techniques were used in the pigeon to study afferent visual input from the suprachiasmatic nucleus (SCN) of the hypothalamus to the nucleus of Edinger-Westphal (EW), the parasympathetic visceral efferent component of the oculomotor complex. Horseradish peroxidase injected into the EW retrogradely labeled numerous neurons in the contralateral SCN, a retinorecipient hypothalamic nucleus, as well as a few neurons in the ipsilateral SCN. Autoradiographic orthograde pathway tracing experiments confirmed that the SCN projects heavily upon the medial subdivision of the contralateral EW and lightly upon the medial subdivision of the ipsilateral EW. Some neurons of the SCN contain substance P and a substance P-positive plexus of fibers was seen in precisely that medial portion of the EW to which the SCN was found to project in the autoradiographic experiments. This substance P-positive fiber plexus in the medial EW was eliminated by bilateral electrolytic lesions of the SCN. These results show that the avian suprachiasmatic nucleus has a heavy contralateral and a much lighter ipsilateral projection to the medial subdivision of the EW and that this projection may be largely substance P positive. Previous studies have suggested that neurons of the medial EW specifically project to the neurons of the ciliary ganglion that control the choriocapillary blood flow of the eye. Since the SCN has been implicated in the control of circadian rhythms in vertebrates, the projection of the SCN to the EW may represent a pathway by which a circadian rhythmicity is imposed on choriocapillary blood flow. Alternatively or in addition, the SCN-EW pathway described in this paper may provide the central neural substrate for a homeostatic regulatory mechanism by which choriocapillary blood flow is controlled by the intensity of retinal illumination.
Effects of H2O Addition on Oil Sand Bitumen Cracking Using a CeO2–ZrO2–Al2O3–FeOx Catalyst (2016)

The behavior of a CeO2–ZrO2–Al2O3–FeOx catalyst typically employed during heavy oil decomposition was investigated in conjunction with the addition of H2O, as a means of improving the upgrading activity and suppressing coke formation on the catalyst. The upgrading of oil sand bitumen diluted with benzene was examined with this catalyst at various FH2O/Fbitumen ratios [where FH2O is the water flow rate (g h–1) and Fbitumen is the bitumen feedstock flow rate (g h–1)] in a fixed-bed flow-type reactor. Under optimal conditions (FH2O/Fbitumen equal to approximately 20) and at a reaction temperature of 693 K, effective catalytic decomposition of the bitumen was observed with the lighter component (gas oil and vacuum gas oil) yield reaching 71 mol % C. In addition, the formation of coke on the catalyst was decreased to less than 14 mol % C. Analyses using quadrupole mass spectrometry determined that this catalyst upgrades the heavy oil through oxidation reactions, in which the lattice oxygen of the iron oxide is consumed and, subsequently, regenerated by the decomposition of water molecules over the catalyst.
Development and evaluation of aceclofenac-loaded mucoadhesive microcapsules (2011)

Microencapsulation is an accepted process used to achieve controlled release and drug targeting for many years. Mucoadhesion has been a topic of interest in the design of drug delivery systems to prolong its intestinal residence time. Mucoadhesion facilitates the intimate contact of the dosage form with the underlying absorption surface for improved bioavailability of drugs. Aceclofenac is a newer nonsteroidal anti-inflammatory drug (NSAID) having short biological half-life of 4-4.3 h, and therefore a sustained release medication is required to get prolonged effect and to reduce fluctuations in drug plasma concentration levels. Aceclofenac microcapsules were prepared employing sodium alginate as the coat material in combination with some mucoadhesive polymers such as (hydroxypropyl methyl cellulose) HPMC, (sodium carboxymethyl cellulose) Sod. CMC, Carbopol and methyl cellulose (MC) (drug:SA:polymer at ratios 2:2:1, 2:3:1 and 2:4:1), following orifice-ionic gelation technique. Infrared (IR) spectroscopy, differential scanning calorimetry and X-ray diffraction studies proved the compositions were compatible, without any interaction between the drug and excipients. The prepared microcapsules were evaluated for various physical and release parameters. The resulted microcapsules were found to be discrete and spherical in scanning electron microscopy studies and free flowing in rheological studies. The size of microcapsules was found to be around 757.44 ± 5.201 μm to 814.46 ± 6.586 μm. The microencapsulation efficiency was found to be higher in HPMC than in Carbopol > MC > Sod. CMC containing formulations, but the swelling index was found to be higher in Sod. CMC formulations. The microcapsules with HPMC exhibited good mucoadhesive property in the in vitro wash-off test. In vitro drug release studies of aceclofenac microcapsules were carried out up to 24 h and they followed zero-order release kinetics with Super Case II mechanism. The drug release from the microcapsules was sustained over a prolonged period with greater retardation in drug:SA:HPMC (2:4:1) containing microcapsules and this proved to be the best formulation.
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung. (1994)

Several non-small cell lung carcinomas (squamous cell carcinomas and adenocarcinomas) were analyzed for protein kinase activity. Soluble protein extracts derived from these tumors and from the lung parenchyma adjacent to the tumors were resolved by Mono Q anion exchange chromatography, and the fractions were assayed for phosphotransferase activity towards in vitro substrates. Myelin basic protein, casein, and a ribosomal S6-1 COOH-terminus peptide were efficient substrates for protein kinases that exhibited elevated phosphotransferase activity in the tumor extracts when compared to extracts derived from the adjacent nonneoplastic lung or from the lung parenchyma from patients with nonneoplastic lung disorders. Casein phosphotransferase activity was resolved into two peaks that eluted at 0.44 M NaCl and 0.56 M NaCl. The second peak was identified as casein kinase 2, based upon immunoreactivity to casein kinase 2-specific antipeptide antibodies and its sensitivity to inhibition by heparin sulfate. Myelin basic protein phosphotransferase activity eluted at 0.44 M NaCl, but Western blot analysis revealed that this could not be ascribed to mitogen-activated protein (MAP) kinases. This tumor associated protein kinase, designated p40TAK, exhibited a molecular mass of approximately 40 kDa upon gel filtration. In addition to myelin basic protein, it phosphorylated S6 peptide analogues and histone H1 on seryl residues. Like casein kinase 2, p40TAK exhibited elevated basal phosphotransferase activity in squamous cell carcinomas and adenocarcinomas of the lung when compared to the nonneoplastic lung parenchyma adjacent to the tumor.
St. Anthony's Nursing Home, Kilduff Castle, Pallasgreen, Limerick. (2015)

This inspection report sets out the findings of a monitoring inspection, the purpose of &#13;\nwhich was following notification of a significant incident or event. This monitoring &#13;\ninspection was un-announced and took place over 1 day(s). &#13;\nThe inspection took place over the following dates and times&#13;\nFrom: To:&#13;\n19 August 2015 09:05 19 August 2015 20:30
Aldosterone antagonists. 3. Synthesis and activities of steroidal 7.alpha.-(alkoxycarbonyl)-15,16-methylene spirolactones (1990)

Several A- and D-ring substituted steroidal 7 alpha-alkoxycarbonyl spirolactones were synthesized with the purpose of increasing the aldosterone antagonistic potency and reducing the endocrinological side effects relative to the standard drug spironolactone. It was found that the 15 beta,16 beta-methylene derivative 17 exhibited a 2-fold higher aldosterone antagonistic activity compared to either spironolactone or the 15,16-unsubstituted derivative 29 while showing remarkably reduced antiandrogenicity.
Fast handover in cellular networks with femtocells (2012)

With the advent of femtocells in cellular networks, the inter-cell handover process will become more complex, frequent and time-sensitive. The legacy handover procedures in 3G and LTE systems were originally designed for handovers between macrocells whose base stations are part of the mobile core networks. The use of the public internet to connect the femtocell base station with the mobile core network will contribute to higher latency if such legacy handover procedures are employed over femtocells. This makes the legacy handover procedures slower, and in most cases inefficient. In the absence of a specific standardized procedure that involves femtocells, rather than using existing procedures designed to handle handovers between macrocells, we propose a new Prefetch-based Fast Handover procedure that is designed to overcome the drawbacks introduced by the usage of the public internet for message paths between femtocell base stations and the mobile core network. The new procedure can be introduced into the existing LTE infrastructure with few modifications to the femtocell base station architecture, and the core network packet flows. The proposed procedure simplifies and speeds the handover procedure at the cost of consuming more network resources at the femtocell base station.
Molecular Characterization of IgA- and/or IgG-Switched Chronic Lymphocytic Leukemia B Cells (1997)

The immunoglobulin (Ig) variable region (V) genes expressed by IgM chronic lymphocytic leukemia (CLL) B cells display little or no somatic mutations. However, preliminary findings have shown that Ig V genes of IgA and IgG CLLs may be somatically mutated, suggesting that isotype-switched CLLs may represent a “subtype” of the disease. To investigate the degree and nature of somatic mutations and the role of antigen (Ag) in the clonal selection and expansion of isotype-switched CLLs, and to determine whether specific oncogene or tumor suppressor gene mutations are associated with isotype-switched CLLs, we analyzed the expressed Ig VH gene, bcl-1 and bcl-2 proto-oncogene, and p53 tumor suppressor gene configurations of 3 IgA-, 1 IgG-, and 1 IgA/IgG-expressing CLLs. These isotype-switched CLL B cells expressed surface HLA-DR, CD19, CD23, and CD5, and displayed no alterations of the bcl-1 and bcl-2 oncogenes and the p53 tumor-suppressor gene. The cDNA VH -D-JH gene sequence was joined with that of the Cα gene in the B cells of the three IgA CLLs, and with that of the Cγ gene in the IgG CLL B cells. In the IgA/IgG-coexpressing CLL B cells, identical VH -D-JH cDNA sequences were spliced to either Cα or Cγ genes. In all five CLLs, the pattern of Cμ DNA probe hybridization to the digested genomic DNAs was consistent with deletion of the Cμ exon from the rearranged Ig gene locus, suggesting that these CLL B cells had undergone DNA switch recombination. In one IgA CLL, the expressed VH gene was unmutated. In all other class-switched CLLs, the Ig VH segment gene was mutated, but the point mutations were not associated with intraclonal diversification. In one IgA and in the IgA/IgG-coexpressing CLL, the nature and distribution of the mutations were consistent with Ag selection. These findings suggest that IgA- and/or IgG-expressing CLLs represent, in their VH gene structure, transformants of B cells at different stages of ontogeny. They also suggest that Ag may play a role in the clonal selection of some of these isotype-switched leukemic cells, but bcl-1 and bcl-2 oncogene rearrangements and p53 tumor suppressor gene mutation are not associated with the pathogenesis of isotype-switched CLLs.
Cold Plasma-Treated Ringer’s Saline: A Weapon to Target Osteosarcoma (2020)

Osteosarcoma (OS) is the main primary bone cancer, presenting poor prognosis and difficult treatment. An innovative therapy may be found in cold plasmas, which show anti-cancer effects related to the generation of reactive oxygen and nitrogen species in liquids. In vitro models are based on the effects of plasma-treated culture media on cell cultures. However, effects of plasma-activated saline solutions with clinical application have not yet been explored in OS. The aim of this study is to obtain mechanistic insights on the action of plasma-activated Ringer's saline (PAR) for OS therapy in cell and organotypic cultures. To that aim, cold atmospheric plasma jets were used to obtain PAR, which produced cytotoxic effects in human OS cells (SaOS-2, MG-63, and U2-OS), related to the increasing concentration of reactive oxygen and nitrogen species generated. Proof of selectivity was found in the sustained viability of hBM-MSCs with the same treatments. Organotypic cultures of murine OS confirmed the time-dependent cytotoxicity observed in 2D. Histological analysis showed a decrease in proliferating cells (lower Ki-67 expression). It is shown that the selectivity of PAR is highly dependent on the concentrations of reactive species, being the differential intracellular reactive oxygen species increase and DNA damage between OS cells and hBM-MSCs key mediators for cell apoptosis.
Protective effect of taurine against alendronate‐induced gastric damage in rats (2004)

Alendronate (ALD) causes serious gastrointestinal adverse effects. The aim of this study was to investigate whether taurine (TAU), a semi-essential amino acid and an antioxidant, improves the alendronate-induced gastric injury. Rats were administered 20 mg/kg ALD by gavage for 4 days, either alone or following treatment with TAU (50 mg/kg, i.p.). On the last day of treatment, following drug administration, pylorus ligation was performed and 2 h later, rats were killed and stomachs were removed. Gastric acidity and tissue ulcer index values, lipid peroxidation and glutathione (GSH) levels, myeloperoxidase (MPO) activity as well as the histologic appearance of the stomach tissues were determined. Chronic oral administration of ALD induced significant gastric damage, increasing lipid peroxidation, MPO activity and collagen content, as well as decreasing tissue GSH levels. Treatment with TAU prevented the damage and also the changes in biochemical parameters. Findings of the present study suggest that ALD induces oxidative gastric damage by a local irritant effect, and that TAU ameliorates this damage by its antioxidant and/or membrane-stabilizing effects.
Une Nouvelle approche réaliste de simulation d'éclairage dans un environnement diffus (1991)

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Hierarchical Featureless Tracking for Position-Based 6-DoF Visual Servoing (2006)

Classical position-based visual servoing approaches rely on the presence of distinctive features in the image such as corners and edges. In this contribution we exploit a hierarchical approach for object detection, initial-pose estimation, and real-time tracking based first on colour distribution and subsequently on the shape and texture information. The shape model of the object is not limited to surface primitives but allow for any free-form surface not subject to self-occlusion. We evaluate the approach as part of a handshake scenario where a 7-DoF robot takes a free moving object over from a human
The impact of anxiety on conversion from mild cognitive impairment to Alzheimer's disease (2009)

In contrast to two other recent studies that showed anxiety predicted cognitive decline or conversion to AD, in this clinic-based sample, state anxiety was not a significant predictor. However, higher Trait anxiety predicted a lower risk of future conversion to AD. Further research with systematic long-term follow-up in larger samples is needed to clarify the role of state and trait anxiety in predicting MCI conversion to AD.
Comparison of broadcasting techniques for mobile ad hoc networks (2002)

Network wide broadcasting in Mobile Ad Hoc Networks provides important control and route establishment functionality for a number of unicast and multicast protocols. Considering its wide use as a building block for other network layer protocols, the MANET community needs to standardize a single methodology that efficiently delivers a packet from one node to all other network nodes. Despite a considerable number of proposed broadcasting schemes, no comprehensive comparative analysis has been previously done. This paper provides such analysis by classifying existing broadcasting schemes into categories and simulating a subset of each, thus supplying a condensed but comprehensive side by side comparison.The simulations are designed to pinpoint, in each, specific failures to network conditions that are relevant to MANETs, e.g., bandwidth congestion and dynamic topologies. In addition, protocol extensions using adaptive responses to network conditions are proposed, implemented and analyzed for one broadcasting scheme that performs well in the comparative study.
The effects of ultrasound irradiation on a biodegradable 50–50% copolymer of polylactic and polyglycolic acids (1994)

The aim of this study was to investigate the effects of ultrasound irradiation on a biodegradable drug delivery system. Microporous, disk-shaped specimens of a 50-50% copolymer of polylactic and polyglycolic acids were gel cast from an acetone solution. A protein was incorporated in these specimens, which were then immersed in phosphate buffered saline and subjected to ultrasound irradiation every second day. The investigation was performed in two phases: in the first, a study was performed for 58 days to determine if ultrasonic irradiation affected the kinetics of protein release from the specimens. In the second phase, effects of frequency and duration of the ultrasound signal on the degradation of the implant were studied for 40 days. The results indicate that ultrasound irradiation resulted in almost a threefold increase in protein elution from the specimens. Both the ultrasound frequency and signal duration affected the molecular weight loss and mass loss, and changed the overall degradation kinetics of the polymer.
Ceramic membranes: High filtration area packing densities improve membrane performance (2011)

New tubular ceramic membranes have been developed that provide a high packing density of the filtration area. These new ceramic membrane filter elements have been proven in case studies in oily wastewater treatment applications. Steffen Heidenreich and Winfried Michell of Pall Filtersystems GmbH describe the findings.