gebhart/patrepeval huggingface dataset:
Magnetic properties of CoNiPt and CoNiPd thin films (1991)

CoNiPt and CoNiPd thin films were investigated for high-density longitudinal recording media. The samples were prepared by dc magnetron sputtering. Concentration of Pt or Pd was controlled by changing the number of Pt or Pd chips put on the Co 20 at. % Ni target. It was observed that the coercivity of the samples increased with increasing the Pt or Pd concentration. The x-ray diffraction intensity of Co(002) of the CoNiPt and CoNiPd samples also increased as Pt and Pd content increased, respectively. As a result, it was found that the coercivity increased as the intensity of Co(002) in both films increased. There was no significant difference between CoNi and CoNiPt and CoNiPd films in SEM surface micrographs. The cause of the difference in coercivity may be attributed to the difference in magnetocrystalline anisotropy of the films.
Ovule development: identification of stage-specific and tissue-specific cDNAs. (1996)

A differential screening approach was used to identify seven ovule-specific cDNAs representing genes that are expressed in a stage-specific manner during ovule development. The Phalaenopsis orchid takes 80 days to complete the sequence of ovule developmental events, making it a good system to isolate stage-specific ovule genes. We constructed cDNA libraries from orchid ovule tissue during archesporial cell differentiation, megasporocyte formation, and the transition to meiosis, as well as during the final mitotic divisions of female gametophyte development. RNA gel blot hybridization analysis revealed that four clones were stage specific and expressed solely in ovule tissue, whereas one clone was specific to pollen tubes. Two other clones were not ovule specific. Sequence analysis and in situ hybridization revealed the identities and domain of expression of several of the cDNAs. O39 encodes a putative homeobox transcription factor that is expressed early in the differentiation of the ovule primordium; O40 encodes a cytochrome P450 monooxygenase (CYP78A2) that is pollen tube specific. O108 encodes a protein of unknown function that is expressed exclusively in the outer layer of the outer integument and in the female gametophyte of mature ovules. O126 encodes a glycine-rich protein that is expressed in mature ovules, and O141 encodes a cysteine proteinase that is expressed in the outer integument of ovules during seed formation. Sequences homologous to these ovule clones can now be isolated from other organisms, and this should facilitate their functional characterization.
Early analysis tools for system-on-a-chip design (2002)

The paper describes the need for early analysis tools to enable developers of today's system-on-a-chip (SoC) designs to take advantage of pre-designed components, such as those found in the IBM Blue Logic® Library, and rapidly explore high-level design alternatives to meet their system requirements. We report on a new approach for developing high-level performance models for these SoC designs and outline how this performance analysis capability can be integrated into an overall environment for efficient SoC design.
Influence of Water Treatment of LaF3 Crystal on LaF3-Based Oxygen Sensor Workable at Room Temperature (1991)

The effects of a water treatment of the LaF 3 single crystal on an LaF 3 -based oxygen sensor were investigated. It was found that the oxygen-sensing properties were significantly affected by the water treatment depending on the perovskite-type oxides (LaCrO 3 , LaCoO 3 , La 0.8 Ca 0.2 MnO 3 ) used as the sensing electrode material and the duration of the treatment. As revealed by XPS, the treatment induced the incorporation of oxygen in the surface region of the LaF 3 crystal, leading to an increase in the number of electrons of the electrochemical reduction of oxygen from 1 or 2 to 4.
Correlation of carotid intimal-medial thickness with estimated glomerular filtration rate and cardiovascular risk factors in chronic kidney disease (2014)

Carotid intimal-medial thickness (CIMT) predicts future vascular events in the general population. However, the correlation of traditional cardiovascular risk factors and stages of chronic kidney disease (CKD) with CIMT is not studied extensively. To determine the correlation of CIMT with traditional cardiovascular risk factors like age, body mass index (BMI), dyslipidemia and various stages of CKD patients, CIMT was measured by means of high-resolution B-mode ultrasonography in 70 CKD patients and compared with the 30 healthy controls. The mean CIMT in patients was 0.86 ± 0.21 mm vs 0.63 ± 0.17 mm in healthy age- and sex-matched controls (P <0.001). There was a significant univariate positive correlation between CIMT and age (r = 0.605, P <0.001), BMI (r = 0.377, P = 0.001), total cholesterol (r = 0.236, P ≤0.018) and serum triglyceride (r = 0.387, P ≤0.001). No statistically significant correlation was found between mean CIMT and estimated glomerular filtration rate (eGFR) (r = -0.02, P = 0.30), very low-density lipoprotein and high-density lipoprotein-cholesterol. Atherosclerotic changes very well correlate with the traditional cardiovascular risk factors like age, BMI, serum total cholesterol and serum triglyceride level in CKD patients. Even though CIMT was marginally more in the late stages of CKD patients, no statistically significant correlation was found with CIMT and eGFR.
Infrared laser-induced photochemistry at low temperatures: dramatic isotope and stereochemical selectivity (1976)

A combination of matrix isolation and i.r. laser photochemistry has allowed the selective reaction of molecules of 13CO enriched [Fe(CO)4] which differ only in the stereochemical distribution of isotopic CO groups.
In plane manipulation of a dielectric nanobeam with gradient optical forces (2013)

In this paper we investigate the optical forces induced by localized optical modes propagating along three parallel waveguides, of which only the central one is free to move. In this configuration, when all three waveguides are identical, the components of the optical-force acting on the free beam are decoupled along the axis of symmetry. As a result, two dimensional optomechanical control of the central waveguide, like single-mode optical trapping, can be achieved. We also study non symmetric configurations, that can be used, for example, to tailor the position of the optical trap. Unlike other techniques that rely on buckling, multi-mode excitation or radiation-pressure, single-mode optomechanical-operation should help the realization of faster and simpler on-chip positioning of a single nanobeam since most of the parameters involved can be controlled with great precision.
Use of a platelet-fibrinogen-thrombin mixture as a corneal adhesive: experiments with sutureless lamellar keratoplasty in the rabbit. (1975)

A platelet-fibrinogen-thrombin mixture utilizing autologous platelets was studied for its potential as a corneal adhesive. In the rabbit it demonstrated sufficient adhesive properties to allow 50 per cent of lamellar keratoplasties (autotransplants) to remain in place without the use of sutures. The mixture retains significant adhesive properties for four to six days. It is simple to prepare and apply. It also appears nonantigenic and nontoxic to the cornea; it does not incite inflammation, nor interfere with corneal clarity or the regrowth of corneal epithelium.
Propagation of ultrasonic guided waves in lap-shear adhesive joints (2004)

This paper deals with the propagation of ultrasonic guided waves in adhesively-bonded lap-shear joints. The topic is relevant to ultrasonic bond inspection in aerospace components. Specifically, the propagation of the lowest-order, antisymmetric a<sub>0</sub> mode through the joint is examined. This mode can be easily generated and detected in the field due to the predominant out-of-plane displacements at the surface of the test piece. An important aspect is the mode conversion at the boundaries between the single-plate adherends and the multilayer overlap. The a<sub>0</sub> strength of transmission is studied for three different bond states in aluminum joints, namely a fully cured adhesive bond, a poorly cured adhesive bond, and a slip bond. Theoretical predictions based on the Global Matrix Method indicate that the dispersive behavior of the guided waves in the multilayer overlap is highly dependent on bond state. Experimental tests of the joints are conducted by a hybrid, broadband laser/air-coupled ultrasonic setup in a through-transmission configuration. This system does not require any wet coupling and it can be moved flexibly across the test piece. The Gabor Wavelet transform is employed to extract energy transmission coefficients in the 100 kHz - 1.4 MHz range for the three different bond states examined. The cross-sectional mode shapes of the guided waves are shown to have a substantial role in the energy transfer through the joint. A rationale for the selection of the a<sub>0</sub> excitation frequencies highly sensitive to bond state will be given.
SNPs in Multi-Species Conserved Sequences (MCS) as useful markers in association studies: a practical approach (2007)

Our results showed that MCS can easily be used to prioritize markers for follow-up and candidate gene association studies. We believe that this novel approach demonstrates a paradigm for expediting the search for genes contributing to complex diseases.
Multidimensional single-cell modeling of cellular signaling (2020)

Abstract Cell-to-cell differences in signaling components can lead to qualitatively different responses to stimuli. Understanding this heterogeneity in signaling response is limited by the inability of time-lapse methods to measure multiple pathway components simultaneously in situ. Here, we present Distribution-Independent Single-Cell ODE modeling (DISCO), a computational method for inference of continuous single-cell signaling dynamics from multiplexed snapshot data. We used DISCO to analyze signaling in the MAPK/ERK pathway of HEK293T cells stimulated with the growth factor EGF. Our model recapitulates known features of the ERK signaling response and enables the detection of hidden cell-to-cell variation in seemingly homogeneous samples. Further, DISCO analysis suggested that the MAPK/ERK pathway transmits signal duration rather than amplitude, and that cell-to-cell variation in MAPK/ERK signaling response depends primarily on initial cell states. Finally, we applied an extended version of DISCO to explain changes in signaling kinetics due to overexpression of a disease-relevant protein. Overall, DISCO enables a deeper understanding of how single-cell variation affects cellular responses in complex signaling systems.
Purification, Substrate Specificity and Binding, β-Decarboxylase Activity, and Other Properties of Escherichia coli 2-Keto-4-hydroxyglutarate Aldolase (1972)

Abstract 2-Keto-4-hydroxyglutarate aldolase has been purified to homogeneity from extracts of Escherichia coli grown on nutrient broth. Values of 62,500 and 64,000, respectively, are obtained for the molecular weight of the enzyme by the procedures of gel filtration and sucrose density gradient centrifugation. The aldolase has a pH optimum of 8.6 and does not appear to require divalent metal ions for activity. p-Mercuriphenylsulfonate, iodoacetate, and N-ethylmaleimide partially inhibit enzymatic activity. The aldolase from this source preferentially cleaves or forms the l isomer of 2-keto-4-hydroxyglutarate. When the enzyme is tested with a number of compounds as substrate, it catalyzes the cleavage of only 2-keto-4-hydroxybutyrate and oxalacetate besides 2-keto-4-hydroxyglutarate. A higher degree of specificity is manifested for binding analogs of pyruvate than of glyoxylate, as determined by the extent of enzyme inactivation when the aldolase is incubated with analog compounds in the presence of NaBH4. Extensive loss of aldolase activity occurs when the enzyme is incubated with either pyruvate or glyoxylate in the presence of NaBH4, and 1 mole of 14C-labeled substrate is stably bound per mole of enzyme. Competition studies indicate that pyruvate, glyoxylate, and 2-keto-4-hydroxyglutarate all bind at the same active site of the aldolase. Incubation of 2-keto-4-hydroxyglutarate aldolase with glyoxylate in the presence of cyanide also causes irreversible loss of enzymatic activity, suggesting the formation of a stable aminonitrile with this substrate. Under these conditions, approximately 1 mole of [14C]glyoxylate is bound per mole of aldolase. Irreversible inactivation of aldolase activity by cyanide is not observed with pyruvate. The pure aldolase from E. coli has a higher relative level of β-decarboxylase activity toward oxalacetate than does the enzyme obtained from extracts of bovine liver. Both aldolase and β-decarboxylase activities are lost when the E. coli aldolase is treated with glyoxylate or pyruvate in the presence of NaBH4, suggesting that the same active site participates in both reactions.
The MetaCyc Database (2002)

MetaCyc is a metabolic-pathway database that describes 445 pathways and 1115 enzymes occurring in 158 organisms. MetaCyc is a review-level database in that a given entry in MetaCyc often integrates information from multiple literature sources. The pathways in MetaCyc were determined experimentally, and are labeled with the species in which they are known to occur based on literature references examined to date. MetaCyc contains extensive commentary and literature citations. Applications of MetaCyc include pathway analysis of genomes, metabolic engineering and biochemistry education. MetaCyc is queried using the Pathway Tools graphical user interface, which provides a wide variety of query operations and visualization tools. MetaCyc is available via the World Wide Web at http://ecocyc.org/ecocyc/metacyc.html, and is available for local installation as a binary program for the PC and the Sun workstation, and as a set of flatfiles. Contact metacyc-info@ai.sri.com for information on obtaining a local copy of MetaCyc.
REGULATION AND INHIBITION OF ARACHIDONIC ACID ω-HYDROXYLASES AND 20-HETE FORMATION (2004)

Cytochrome P450-catalyzed metabolism of arachidonic acid is an important pathway for the formation of paracrine and autocrine mediators of numerous biological effects. The omega-hydroxylation of arachidonic acid generates significant levels of 20-hydroxyeicosatetraenoic acid (20-HETE) in numerous tissues, particularly the vasculature and kidney tubules. Members of the cytochrome P450 4A and 4F families are the major omega-hydroxylases, and the substrate selectivity and regulation of these enzymes has been the subject of numerous studies. Altered expression and function of arachidonic acid omega-hydroxylases in models of hypertension, diabetes, inflammation, and pregnancy suggest that 20-HETE may be involved in the pathogenesis of these diseases. Our understanding of the biological significance of 20-HETE has been greatly aided by the development and characterization of selective and potent inhibitors of the arachidonic acid omega-hydroxylases. This review discusses the substrate selectivity and expression of arachidonic acid omega-hydroxylases, regulation of these enzymes during disease, and the application of enzyme inhibitors to study 20-HETE function.
Poly(carbon suboxide). Characterization, Polymerization, and Radical Structure (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPoly(carbon suboxide). Characterization, Polymerization, and Radical StructureA. W. Snow, H. Haubenstock, and N.-L. YangCite this: Macromolecules 1978, 11, 1, 77–86Publication Date (Print):January 1, 1978Publication History Published online1 May 2002Published inissue 1 January 1978https://pubs.acs.org/doi/10.1021/ma60061a015https://doi.org/10.1021/ma60061a015research-articleACS PublicationsRequest reuse permissionsArticle Views298Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Using the motor to monitor pump conditions (1996)

When the load of a mechanical device being driven by a motor changes, whether in response to changes in the overall process or changes in the performance of the driven device, the motor inherently responds. For induction motors, the current amplitude and phase angle change as the shaft load changes. By examining the details of these changes in amplitude and phase, load fluctuations of the driven device can be observed. The usefulness of the motor as a transducer to improve the understanding of devices with high torque fluctuations, such as positive displacement compressors and motor-operated valves, has been recognized and demonstrated for a number of years. On such devices as these, the spectrum of the motor current amplitude, phase, or power normally has certain characteristic peaks associated with various load components, such as the piston stroke or gear tooth meshing frequencies. Comparison and trending of the amplitudes of these peaks has been shown to provide some indication of their mechanical condition. For most centrifugal pumps, the load fluctuations are normally low in torque amplitude, and as a result, the motor experiences a correspondingly lower level of load fluctuation. However, both laboratory and field test data have demonstrated that the motormore » does provide insight into some important pump performance conditions, such as hydraulic stability and pump-to-motor alignment. Comparisons of other dynamic signals, such as vibration and pressure pulsation, to motor data for centrifugal pumps are provided. The effects of inadequate suction head, misalignment, mechanical and hydraulic unbalance on these signals are presented.« less
A Facile Synthesis of Thioacids from N-Acylbenzotriazoles (2013)

Protected amino/peptide thioacids have been synthesized in pure form in excellent yields and with retention of chirality by using protected aminoacyl- and peptidoylbenzotriazoles as active intermediates.
Echolocating bats face a cocktail party nightmare when they fly together in cluttered environments (2014)

Echolocating bats often operate in the presence of conspecifics and in cluttered environments, which can be characterized as a “cocktail party nightmare.” Each bat's sonar vocalization can result in an echo cascade from objects distributed in direction and range. Adding to the acoustic clutter are the signals from neighboring bats. Past studies demonstrate that bats adapt their echolocation to avoid signal jamming from conspecifics by adjusting the frequencies of their vocalizations, as well as going silent. When bats fly alone in densely cluttered environments, they adjust the frequencies of call pairs to disambiguate overlapping echo streams. How do echolocating bats adapt to both conspecific signals and clutter? We sought to answer this question by flying big brown bats in a large room equipped with high-speed video and audio recording equipment. In baseline trials, bats flew alone in an empty room and were later introduced to an artificial forest, first individually and later in pairs. The echolocation behavior and flight paths are analyzed to evaluate the spectro-temporal adjustments of bat calls and silent behavior as animals progressed from open room, to forest, to forest with conspecifics. The results shed light on how echolocating bats adapt to a “cocktail party nightmare.”
Synthesis and Antitumor Activity of Ellagic Acid Peracetate (2012)

Ellagic acid (1) was synthesized for the first time from methyl gallate through 3-pentagalloylglucose (α-PGG), and ellagic acid peracetate (3,4,3',4'-tetra-O-acetylellagic acid, 2) was derived from 1 by acetylation. Oral administration of 2 suppressed melanoma growth significantly in C7BL/6 immunocompetent mice without having any effect on natural killer (NK) cell activity. Comparison of the immunoenhancing activities of 1 and 2 indicated that the latter compound increased white blood cell quantities in peripheral blood and immune cells enriched from the bone marrow and liver of mice. Therefore, both the antitumor efficacy and the immunity enhancement by 2 were greater than those by 1. In addition, on oral administration neither 1 nor 2 resulted in whole body, liver, or spleen weight changes of normal, tumor-free mice, indicating that these compounds are potentially non-toxic to mice. It was shown that ellagic acid peracetate (2) inhibits B16 melanoma cell growth in vitro, and induces B16 cell apoptosis, corresponding to BCL-2 down-regulation. Collectively, the present data imply that 2 can suppress tumor growth by enhancing mouse immunity and inducing tumor cell apoptosis without apparent side effects.
On Selfish Configuration in Wi-Fi Tethering (2013)

Due to the ease of setting up a Wi-Fi hotspot and the availability of readily configurable mobile operating systems, Wi-Fi tethering can be abused by misbehaving users to gain an unfair advantage in throughput performance. In this paper, we study the problem of detecting selfish nodes in Wi-Fi tethering environments. In particular, selfish nodes can manipulate carrier sensing thresholds to exploit recent advances in physical-layer concurrent transmission technologies as well as short link distance in a tethered network so as to achieve unfair throughput gains while evading detection. We propose a new MAC-layer detection algorithm based on frame sequence numbers that accurately detects selfish nodes.
Piperazine oestrone sulphate and interrupted norethisterone in postmenopausal women: effects on bone mass, lipoprotein metabolism, climacteric symptoms, and adverse effects (2000)

All hormone regimens studied prevented bone loss completely and lowered serum lipids.
Die “moderne sozial-philosophische Betrachtungsweise” und ihr okzidentaler Gegenstand (1999)

In Simmels Entwurf sind also Positivismus und Romantik gleichermaßen überwunden und die "zwei Vergewaltigungen, die den modernen Menschen bedrohen: durch die Natur und durch die Geschichte"1 abgewehrt. Wir dürfen wohl von einer "post-philosophischen" Weltsicht sprechen, einer Betrachtungsweise also, bei der jeglicher begriffliche Absolutismus von vornherein ausgeschlossen ist. Wo die Selbstbesinnung des Menschen nunmehr von einer Aufhebung von allem in die totale Vernunft oder in die totale Historie absehen muß und sich stattdessen mit Studien zur Soziologie (es sei hier beispielsweise auf Simmels "Philosophie des Geldes" verwiesen) oder zur Geschichte der Rationalität (hier wäre Webers Entwicklungsgeschichte des "kapitalistischen Geistes" zu nennen) "begnügen" muß.