gebhart/patrepeval huggingface dataset:
The PLAUR signaling promotes chronic pruritus (2022)

Chronic itch is a complex sensation of the skin frequently associated with skin diseases, such as atopic dermatitis (AD) and psoriasis. Although Serpin E1 is implicated in chronic itch, its receptor and signaling pathways involved in itch are not known. In this study, the clinical relevance of a putative Serpin E1 receptor PLAUR to chronic itch, and the neuro-cutaneous Serpin E1-PLAUR signaling are explored. We found that PLAUR is overexpressed in skin specimens of human lesional AD and lesional psoriasis, and sensory neurons innervating MC903-induced AD-like murine skin. Murine PLAUR<sup>+</sup> sensory neurons responded to Serpin E1, resulting in enrichment of numerous itch- and inflammation-related genes and their protein release. PLAUR resides in TLR2<sup>+</sup> neurons and Serpin E1 stimulus led to transcriptional upregulation of TLR2 and its co-signaling proteins. Agonists of TLR2 propagated itch-related gene transcription including BNP, OSM, and PAR2. OSM induced acute itch in mice and promoted G-CSF and IL-8 release from human keratinocytes. Serpin E1 inhibitor reduced MC903-induced itch, epidermal hyperplasia, immunocyte infiltration, and resulted in lower transcription/expression levels of Serpin E1 and OSM. Taken together, the PLAUR-TLR2-OSM signaling promotes skin-nerve communication, cutaneous inflammation, and itch, all feeding into an aggravation of AD and exaggerated itch circuits.
Antenne à formation de faisceau adaptative à base d'un matériau BIE contrôlable pour une station de base GSM, DCS et UMTS (2005)

National audience
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of Bs0 meson decays to J/ψη and J/ψη′ (2012)

First evidence of the B0→J/ψω decay is found and the Bs0→J/ψη and Bs0→J/ψη′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb−1 collected by the LHCb experiment in proton–proton collisions at a centre-of-mass energy of s=7 TeV. The branching fractions of these decays are measured relative to that of the B0→J/ψρ0 decay:B(B0→J/ψω)B(B0→J/ψρ0)=0.89±0.19(stat)−0.13+0.07(syst),B(Bs0→J/ψη)B(B0→J/ψρ0)=14.0±1.2(stat)−1.5+1.1(syst)−1.0+1.1(fdfs),B(Bs0→J/ψη′)B(B0→J/ψρ0)=12.7±1.1(stat)−1.3+0.5(syst)−0.9+1.0(fdfs), where the last uncertainty is due to the knowledge of fd/fs, the ratio of b-quark hadronization factors that accounts for the different production rate of B0 and Bs0 mesons. The ratio of the branching fractions of Bs0→J/ψη′ and Bs0→J/ψη decays is measured to beB(Bs0→J/ψη′)B(Bs0→J/ψη)=0.90±0.09(stat)−0.02+0.06(syst).
Three-Dimensional Fluorophore Orientation Imaging with Multiview Polarized Microscopy (2018)

We show that polarized fluorescence microscopes make band-limited measurements in the angular frequency domain. We use this result to propose and demonstrate efficient algorithms for reconstructing three-dimensional fluorophore orientations from multiview polarized microscope data.
Multi-protocol active messages on a cluster of SMP's (1997)

Clusters of multiprocessors, or Clumps, promise to be the supercomputers of the future, but obtaining high performance on these architectures requires an understanding of interactions between the multiple levels of interconnection. In this paper, we present the first multi-protocol implementation of a lightweight message layer---a version of Active Messages-II running on a cluster of Sun Enterprise 5000 servers connected with Myrinet. This research brings together several pieces of high-performance interconnection technology: bus backplanes for symmetric multiprocessors, low-latency networks for connections between machines, and simple, user-level primitives for communication. The paper describes the shared memory message-passing protocol and analyzes the multi-protocol implementation with both microbenchmarks and Split-C applications. Three aspects of the communication layer are critical to performance: the overhead of cache-coherence mechanisms, the method of managing concurrent access, and the cost of accessing state with the slower protocol. Through the use of an adaptive polling strategy, the multi-protocol implementation limits performance interactions between the protocols, delivering up to 160 MB/s of bandwidth with 3.6 microsecond end-to-end latency. Applications within an SMP benefit from this fast communication, running up to 75% faster than on a network of uniprocessor workstations. Applications running on the entire Clump are limited by the balance of NIC's to processors in our system, and are typically slower than on the NOW. These results illustrate several potential pitfalls for the Clumps architecture.
HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART (2016)

HIV DNA is a marker of HIV persistence that predicts HIV progression and remission, but its kinetics in early acute HIV infection (AHI) is poorly understood. We longitudinally measured the frequency of peripheral blood mononuclear cells harboring total and integrated HIV DNA in 19 untreated and 71 treated AHI participants, for whom 50 were in the earliest Fiebig I/II (HIV IgM-) stage, that is ≤2weeks from infection. Without antiretroviral therapy (ART), HIV DNA peaked at 2weeks after enrollment, reaching a set-point 2weeks later with little change thereafter. There was a marked divergence of HIV DNA values between the untreated and treated groups that occurred within the first 2weeks of ART and increased with time. ART reduced total HIV DNA levels by 20-fold after 2weeks and 316-fold after 3years. Therefore, very early ART offers the opportunity to significantly reduce the frequency of cells harboring HIV DNA.
On the origins of the sensory output from the bladder: the concept of afferent noise (2009)

For many people a recurrent strong desire to void, sometimes with incontinence, diminishes their quality of life. At present there are few insights into what underlies these problems. The condition is described as the 'overactive bladder symptom complex' but this definition is proving to be unhelpful. It focuses on overt bladder contractions rather than the main problem, which is altered and heightened sensation. Also, current approaches that describe bladder sensations as episodic and leading to voiding as 'first and second sensation to void' might also be misleading if they are taken too literally and used to suggest mechanisms. Current research is beginning to focus on the mechanisms that generate afferent information from the bladder and how it can become altered. As these views develop it is crucial that we appreciate the diversity of the bladder afferent system and distinguish between afferent and sensory information; in this review we explore this underlying complexity. The central nervous system (CNS) receives vast amounts of information from the bladder, which arises from different locations, uses different fibre types and involves different methods. The CNS is continually being bombarded with 'afferent noise'. The challenge now is to understand the nature and components of this 'afferent noise' and which components are essential to sensation. The emerging picture is complex, but this complexity must not be negated or oversimplified. It must be embraced and incorporated it into thinking when designing experiments, analysing data, diagnosing patients and evaluating treatment.
Advancements in predictive plasma formation modeling (2016)

We present highlights from plasma simulations performed in collaboration with Lawrence Livermore National Labs. This modeling is performed to advance the rate of learning about optimal EUV generation for laser produced plasmas and to provide insights where experimental results are not currently available. The goal is to identify key physical processes necessary for an accurate and predictive model capable of simulating a wide range of conditions. This modeling will help to drive source performance scaling in support of the EUV Lithography roadmap. The model simulates pre-pulse laser interaction with the tin droplet and follows the droplet expansion into the main pulse target zone. Next, the interaction of the expanded droplet with the main laser pulse is simulated. We demonstrate the predictive nature of the code and provide comparison with experimental results.
Microscale solar cells for high concentration on polycrystalline Cu(In,Ga)Se2 thin films (2011)

We report high concentration experiments on polycrystalline thin film solar cells. High level regime is reached, thanks to the micrometric scale of the Cu(In,Ga)Se2 cells, which strongly decreases resistive losses. A 4% absolute efficiency increase is obtained at a concentration of ×120, and current densities as high as 100 A/cm2 can be measured. These results show that the use of polycrystalline thin films under high concentration is possible, with important technological consequences.
Local intra-arterial thrombolysis in limb-threatening ischaemia. (1995)

The purpose of this study was to determine the angiographic and clinical success rate and the immediate limb salvage and mortality rate after intra-arterial thrombolysis in limb-threatening ischaemia. A retrospective study of 66 patients treated with intra-arterial thrombolysis for 71 episodes of limb-threatening ischaemia was carried out. Immediate angiographic recanalisation rate, pre- and post-treatment ankle-brachial index (ABI) and clinical stage were established. Major amputations and deaths were recorded. The immediate primary angiographic recanalisation was complete in 25 cases and partial in 20 cases. Combined complete plus partial recanalisation rate was thus 63.4% (45/71). The overall mean ABI after treatment was significantly higher than before treatment (0.35 versus 0.68), excluding patients undergoing amputation. Clinical improvement was achieved in 59.2% of cases for one month after treatment. The amputation rate was 18.3% during the first month and 29.6% during the median follow-up of 16 weeks. The mortality rates were 6.1% and 33.3% respectively. Despite a high mortality the complications of thrombolysis were few emphasizing the relative safety of this method in treating limb threatening ischaemia. Furthermore, thrombolysis may identify the underlying pathology, which can be corrected by additional surgery or interventional procedure.
09: Softwaretechnik 1, Übung, SS 2017, 26.05.2017 (2017)

09 | 0:00:00 Starten 0:00:08 Risks to the Public 0:08:16 Übung 2 0:08:36 Aufgabe 1 0:23:16 Aufgabe 2 0:33:49 Aufgabe 3: Durchführbarkeitsuntersuchung 0:37:51 Aufgabe 4 : Erzeugen eines Bilds aus Dreiecken 1:10:36 Aufgabe 5 : commons-cli in Maven einbinden
Germanium. XVII (1926)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGermanium. XVIIL. M. DennisL. M. DennisMore by L. M. Dennis and A. W. LaubengayerA. W. LaubengayerMore by A. W. LaubengayerCite this: J. Phys. Chem. 1926, 30, 11, 1510–1526Publication Date (Print):November 1, 1926Publication History Published online1 May 2002Published inissue 1 November 1926https://doi.org/10.1021/j150269a007RIGHTS & PERMISSIONSArticle Views59Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (836 KB) Get e-Alerts
In-Situ Strain Gauge: Based on Photoluminescence of Quantum Dots (2015)

Due to that the spectra of CdSe/ZnS core/shell nanocrystals showed a wavelength shift when under external pressures, researches are conducted to design a wavelength shift-based strain or stress gauge. However, the spectrum's shift can only be subtly sensitive when the pressure applied to nanocrystals reaches GPa, which makes the gauge hard to be applied to practice. In this paper, it was found that the photoluminescence(PL) intensity of CdSe/ZnS core/shell quantum dots (QDs)epoxy resin composites changes significantly with strain. Meanwhile, the changes remains stable after 3-5 cycles. We coated the QDs-epoxy resin composites on the surface of metal tensile sample, the PL intensity and strain changes synchronously. In addition, it has been successfully proved that the variation of QDs’ concentrations along with the strain is the main reason for the photoluminescence intensity changing. This research has shown the possibility that this kind of nanocomposite can be designed as a new strain gauge to quantitatively detect stress or strain in-situ by being coated on the structure surface.
Acute coronary syndromes, response to clopidogrel, and worsened cardiovascular outcomes: the hen and the egg dilemma (2006)

We thank Dr Serebruany for his interest and careful reading of our article entitled “Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation”.

He critically remarked the influence of acute coronary syndromes (ACS) on response to clopidogrel in our patient cohort. We agree with Dr Serebruany that acute coronary events may have substantial influence on measured platelet activity and, of course, also influence cardiovascular outcome. The very justified comment is supported by previous clinical studies.1,2

Our aim of the present manuscript was to provide data on platelet response after administration of 600 mg loading dose of clopidogrel in an unselected consecutive patient cohort undergoing coronary stenting and to investigate its association on cardiovascular outcome. The measurement was done in a clinically practical way …
Activation of the anaerobic ribonucleotide reductase by S-adenosylmethionine. (2005)

International audience
QoS-aware service location in mobile ad-hoc networks (2004)

The advent of light-weight terminals (e.g., PDA) with integrated communication capabilities facilitates service access and hosting anytime, anywhere. However, effective service access requires dealing with the service's QoS, including related resource consumption. This paper introduces a comprehensive framework for QoS-aware service location in ad hoc networks. Our framework divides into: (i) QoS specification that is expressive enough to capture most significant QoS-related properties, and concise enough to have minimal computation cost associated with QoS management; and (ii) a benefit function for evaluating the overall benefit of service instances available in the network from the standpoint of QoS regarding both the user's perspective and resource consumption on hosts. Application of the proposed QoS framework is addressed in the context of the mobile ADHoc WS system, which supports QoS-aware location of Web services deployed in mobile ad hoc networks.
A portable digitally controlled oscillator using novel varactors (2005)

This work presents a portable digitally controlled oscillator (DCO) by using two-input NOR gates as a digitally controlled varactor (DCV) in fine-tuning delay cell design. This novel varactor uses the gate capacitance difference of NOR gates under different digital control inputs to establish a DCV. Thus proposed DCO can improve delay resolution 256 times better than a single buffer design. This study also examines different types of NOR/NAND gates (2-input or 3-input) for DCV. The proposed DCO with novel DCV can be implemented with standard cells, and thus it can be ported to different processes in short time. Furthermore, the final circuit layout can be generated using an auto placement and routing (APR) tools. A test chip demonstrates that LSB resolution of the DCO can be improved to 1.55 ps with standard 0.35-/spl mu/m 2P4M CMOS digital cell library. The proposed DCO has good performance in terms of fine resolution, high portability, and short design turnaround cycle compared with conventional DCO designs.
Spatio-Temporal Activity Detection and Recognition in Untrimmed Surveillance Videos (2021)

This work presents a spatio-temporal activity detection and recognition framework for untrimmed surveillance videos consisting of a three-step pipeline: object detection, tracking, and activity recognition. The framework relies on the YOLO v4 architecture for object detection, Euclidean distance for tracking, while the activity recognizer uses a 3D Convolutional Deep learning architecture employing spatio-temporal boundaries and addressing it as multi-label classification. The evaluation experiments on the VIRAT dataset achieve accurate detections of the temporal boundaries and recognitions of activities in untrimmed videos, with better performance for the multi-label compared to the multi-class activity recognition.
Preparation of catalysts for the Fischer–Tropsch synthesis by the deposition of cobalt reduced with NaBH4 onto a support (2015)

A new method for the preparation of catalysts for the Fischer–Tropsch synthesis is proposed; it consists in the deposition of cobalt metal on a support at the instant of reduction from salts with a solution of NaBH4. The catalysts thus prepared are stable in air, and they do not require further high-temperature activation by hydrogen. The specific rate of CO conversion was 3.4–3.7 molCO mol-1 Co h–1; the selectivity for higher hydrocarbons was up to 88 mol %, and the hydrocarbon chain growth index α was up to 0.87.
Star-Cap: Cluster Power Management Using Software-Only Models (2014)

Star-Cap is a high-fidelity, real-time power management system for clusters. Star-Cap's cluster power management module uses software-only power models to implement a proactive power capping mechanism with the ability to distribute a cluster's power budget non-uniformly across nodes. We evaluated Star-Cap on a variety of MapReduce-style workloads running on a low-power cluster. Depending on application and platform, Star-Cap improves cluster throughput by 14-43% compared to using a uniform power cap distribution policy with a purely reactive power capping mechanism, even one based on real physical measurements. Furthermore, Star-Cap maintains cluster throughput while reducing overall cluster power budget by 14% with no additional capital or operating cost. Star-Cap's proactive power capping mechanism also improves response time to power cap violations by a factor of 2 to 10. Star-Cap's overhead for collecting, computing, and reporting data is less than 1% CPU utilization.
Pseudomonas aeruginosa Biofilms Exposed to Imipenem Exhibit Changes in Global Gene Expression and β-Lactamase and Alginate Production (2004)

The lungs of cystic fibrosis (CF) patients are commonly colonized with Pseudomonas aeruginosa biofilms. Chronic endobronchial P. aeruginosa infections are impossible to eradicate with antibiotics, but intensive suppressive antibiotic therapy is essential to maintain the lung function of CF patients. The treatment often includes beta-lactam antibiotics. How these antibiotics influence gene expression in the surviving biofilm population of P. aeruginosa is not clear. Thus, we used the microarray technology to study the effects of subinhibitory concentrations of a beta-lactam antibiotic, imipenem, on gene expression in biofilm populations. Many genes showed small but statistically significant differential expression in response to imipenem. We identified 34 genes that were induced or repressed in biofilms exposed to imipenem more than fivefold compared to the levels of induction or repression for the controls. As expected, the most strongly induced gene was ampC, which codes for chromosomal beta-lactamase. We also found that genes coding for alginate biosynthesis were induced by exposure to imipenem. Alginate production is correlated to the development of impaired lung function, and P. aeruginosa strains isolated from chronically colonized lungs of CF patients are nearly always mucoid due to the overproduction of alginate. Exposure to subinhibitory concentrations of imipenem caused structural changes in the biofilm, e.g., an increased biofilm volume. Increased levels of alginate production may be an unintended adverse consequence of imipenem treatment in CF patients.
Radiesse for Aesthetic Soft Tissue Augmentation (2006)

Introduction: Calcium hydroxyapatite (CaHa; also spelled “hydroxylapatite”) is the main mineral component of bone, calcified cartilage, and teeth. It has been used since the 1970s in many specialties, including orthopedics, urology, otolaryngology, maxillofacial surgery, and radiology, as a bioactive implant that promotes chemical attachment of the soft tissue to its surface. In 2001, Radiance FN (now Radiesse) was introduced as a CaHa-based product and approved by the US Food and Drug Administration (FDA) as a radiographic tissue marker, for soft tissue vocal fold augmentation, and for implants in maxillofacial defects. Currently, it is also used outside the United States and off-label in the United States for facial soft tissue augmentation. Microspheres of CaHa are suspended in a mixture of water, glycerin, and carboxymethylcellulose gel that provides a scaffold for tissue infiltration. Once injected, the gel is degraded and the CaHa infiltrates the surrounding cells. CaHa is nonirritating, and the carrier gel components are classified as safe by the FDA. Although a great variety of fillers are currently on the market, CaHa (Radiesse) has demonstrated the longest duration in tissue without any reports of antigenicity, migration, or granuloma formation. In this study, we report our experience with CaHa (Radiesse) for aesthetic soft tissue augmentation. Materials and Methods: A total of 139 patients were treated over an 18-month period at 2 private offices in Argentina and the United States. Exclusion criteria included previous use of permanent tissue fillers in the treatment area. Patients with previous use of hyaluronic acid fillers in the treatment area (up to 1 year prior to the study) were allowed to participate in the study. Radiesse was injected from 1-mL prefilled syringes with 27½-gauge needles in different areas such as nasolabial folds, lips, marionettes lines, cheeks, and cellulite dimples. Patient satisfaction and adverse effects were assessed by both physicians and patients during the procedure and during follow-up visits up to 1 year later. Results: Minimal pain, erythema, edema, and bruising were noted during and immediately after the procedure. All of the patients treated were satisfied with their results after one visit. There were no long-term adverse effects during the study period or on follow-up visits. Evaluation of 75% of the patients 1 year after treatment revealed persistence of filling effects. Discussion: CaHa used for aesthetic soft tissue augmentation yields immediate clinical results with high patient satisfaction.