gebhart/patrepeval huggingface dataset:
Optical phased array filter module with passively compensated temperature dependence (2002)

We present WDM filter-modules, realised in silica-on-silicon which are stabilized against thermal drifts using a modified input coupling section where the thermal expansion of a compensating rod shifts the input fibre thus retuning the filter.
Enhanced Modelling of Interdigitated Planar Schottky Varactor Diodes (2005)

The enhanced modelling of interdigitated planar Schottky varaclor diodcs with short access regions is investigated. The dynamic naturc of the dcplction region is described in detail and suhsequcnt cquaiions are presented for the bias dcpendant lumped elcmcnts in the 1 -dimensional equivalent circuit model. In addition to S-paramelcr extraction. thc rcsults okaincd lrom dc and lMHz measurements at discussed.
X-ray source brightness comparison: Rigaku rotating anode source vs. Kevex microfocus tube (2010)

In 2007, we began to explore alternative x-ray sources for application to refraction-enhanced (phase contrast) x-ray radiography of cryogenic NIF ignition capsules containing frozen deuterium-tritium (D-T) ice layers. These radiographs are currently obtained using Kevex microfocus tubes as backlights, and for these sources the x-ray source size is approximately 5 {micro}m. As part of this exploration, we obtained refraction-enhanced radiographs of empty plastic capsules using the Janus laser facility at LLNL, demonstrating that even large ({approx} 100 {micro}m) sources can be utilized in refraction-enhanced radiography provided the source/sample distance is sufficiently large, and provided the final x-ray detector has sufficient spatial resolution. Essentially, in the current geometry, we rely on a small source to provide spatial resolution and on the source/sample distance to provide refraction contrast, but an equally useful alternative geometry is to use a large source and rely on fine detector spatial resolution to provide spatial resolution and on the sample/detector distance to provide refraction contrast.
[Treatment of advanced kidney cancer using recombinant erythropoietin]. (1997)

Erythropoietin exerts a moderate antitumour effect which needs to be confirmed by a phase II trial of first-line treatment in selected patients.
AN AUTOMATED BENDING SYSTEM FOR THE FABRICATION OF SHIP FRAMES VIA SELF - ADAPTIVE COMPUTER CONTROL (1973)

This report includes discussions of: (a) experiments on the bending of model sections; (b) design and construction of a through feed bending fixture; (c) progress to date on computer control; (d) a modified time schedule; (e) financial summary to date; and an appendix 'An analytical method for the development of load displacement curves for the bending of rectangular beams.' The work of the second six months of the program is summarized and the work planned for the completion of the program is outlined.
Unsupervised discrimination of patterns in spiking neural networks with excitatory and inhibitory synaptic plasticity (2014)

A spiking neural network model is described for learning to discriminate among spatial patterns in an unsupervised manner. The network anatomy consists of source neurons that are activated by external inputs, a reservoir that resembles a generic cortical layer with an excitatory-inhibitory (EI) network and a sink layer of neurons for readout. Synaptic plasticity in the form of STDP is imposed on all the excitatory and inhibitory synapses at all times. While long-term excitatory STDP enables sparse and efficient learning of the salient features in inputs, inhibitory STDP enables this learning to be stable by establishing a balance between excitatory and inhibitory currents at each neuron in the network. The synaptic weights between source and reservoir neurons form a basis set for the input patterns. The neural trajectories generated in the reservoir due to input stimulation and lateral connections between reservoir neurons can be readout by the sink layer neurons. This activity is used for adaptation of synapses between reservoir and sink layer neurons. A new measure called the discriminability index (DI) is introduced to compute if the network can discriminate between old patterns already presented in an initial training session. The DI is also used to compute if the network adapts to new patterns without losing its ability to discriminate among old patterns. The final outcome is that the network is able to correctly discriminate between all patterns-both old and new. This result holds as long as inhibitory synapses employ STDP to continuously enable current balance in the network. The results suggest a possible direction for future investigation into how spiking neural networks could address the stability-plasticity question despite having continuous synaptic plasticity.
Halide-Dependent Mechanisms of Reductive Elimination from Gold(III) (2015)

Two unique organometallic halide series (Ph3P)Au(4-Me-C6H4)(CF3)(X) and (Cy3P)Au(4-F-C6H4)(CF3)(X) (X = I, Br, Cl, F) have been synthesized. The PPh3-supported complexes can undergo both C(aryl)-X and C(aryl)-CF3 reductive elimination. Mechanistic studies of thermolysis at 122 °C reveal a dramatic reactivity and kinetic selectivity dependence on halide ligand. For X = I or F, zero-order kinetic behavior is observed, while for X = Cl or Br, kinetic studies implicate product catalysis. The selectivity for C(aryl)-CF3 bond formation increases in the order X = I &lt; Br &lt; Cl &lt; F, with exclusively C(aryl)-I bond formation when X = I, and exclusively C(aryl)-CF3 bond formation when X = F. Thermodynamic measurements show that Au(III)-X bond dissociation energies increase in the order X = I &lt; Br &lt; Cl, and that ground state Au(III)-X bond strength ultimately dictates selectivities for C(aryl)-X and C(aryl)-CF3 reductive elimination.
The relative power of geodemographics vis a vis person and household level demographic variables as discriminators of consumer behaviour (2004)

A series of novel 5-amido-2-carboxypyrazine derivatives were designed, synthesized and evaluated for the inhibitory activities against the T3SS of Salmonella enterica serovar Typhimurium. Preliminary results displayed that the compounds 2f, 2g, 2h and 2i showed potent inhibitory activities against T3SS. Compound 2h was identified as the most potent T3SS inhibitor and the SPI-1 effector secretion was strongly inhibited by 2h in a dose-dependent manner. The effects of compound 2h on the SPI-1 genes transcription might be via impacting the SicA/InvF regulatory pathway.
Improving the performance and efficiency of an adaptive amplification operation using configurable hardware (poster abstract) (2000)

No abstract available.
Ansatz zur Entwicklung von Treiberbaummodellen zur strategischen luK-Evaluation (2007)

Im vorliegenden Kapitel wird ein Ansatz vorgestellt, der die systematische Entwicklung von Treiberbaummodellen unterstützt. Hierbei steht die strategische IK-Evaluation im Mittelpunkt der Betrachtung, so wie sie zur Bewertung der IT-Infrastruktur von Großkunden durchgeführt werden soll. Entsprechend richtet sich die Methodik weniger auf die Entwicklung von Modellen, die bis ins Detail die betrachteten Perspektiven ausspezifizieren und etwa Konzeptionen eines zu implementierenden Systems darstellen. Vielmehr geht es um die Frage, wie die zur Evaluation relevanten Aspekte fokussiert werden können.
PO-138 Dimethyl fumarate modulation of antioxidant response in cancer cells: therapeutic applications (2018)

Introduction RAS genes are among the most commonly mutated oncogenes in human cancers, where they have been shown to render resistance to chemotherapy. Hence, there is a current need for therapies targeting KRAS mutated tumours. The mutation of KRAS results in deregulated activation of signalling pathways involved in cell proliferation or survival. Thus, it was shown to induce the activation of nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2), which itself controls the expression of a large number of antioxidant enzymes. Dimethyl fumarate (DMF) is a derivative of fumaric acid registered for the treatment of relapsing forms of multiple sclerosis and psoriasis. We previously described an antitumoral effect of DMF, which appeared dependent of the inhibition of the anti-oxidant program driven by NRF2 (Saidu et al. MCT, 2017). Material and methods We combined in vitro and in vivo methods to examine the effect of DMF on cancer cell death and the activation of the NRF2 antioxidant pathway. Results and discussions We have shown the effect of DMF on cell death and the activation of the NRF2/DJ-1 antioxidant pathway according to KRAS status (Saidu et al., Oncotarget, 2017. Our data suggests the dependence on NRF2 observed in the mutated KRAS malignant cells makes them more sensitive to the cytotoxic effect of DMF. Moreover, in contrast to malignant cells, our data shows that the same concentration of DMF has no significant cytotoxic effects on non-tumorigenic cells; but is rather associated with NRF2 activation, decreased ROS and increased GSH levels. Conclusion These results thus open up prospects for the therapeutic use of DMF. They however, also, open up questions such as: how does DMF affect A), NRF2-KEAP1/NRF2-DJ-1 protein interactions? B), other antioxidant proteins? C), are there other NRF2, KEAP1 and/or DJ-1 binding partners that are affected by DMF? To address these questions, we are currently employing tools/techniques such as kinomic analysis, MS, pull-down and co-immunoprecipitation assays; results from which will broaden our understanding on how DMF modulates immune and antioxidant responses in different cancers.
Molecular Dynamics Simulation of the Interaction of Low-Energy Ar and Xe Ions with Copper Clusters on a Graphite Surface (2005)

A molecular-dynamics simulation of sputtering of isolated clusters consisting of 13, 27, and 195 Cu atoms from the (0001) graphite surface by 200-eV Ar and Xe ions is carried out. The angular and energy parameters of sputtered Cu atoms and scattered ions are discussed.
CD4+CD28null T cells in autoimmune disease: pathogenic features and decreased susceptibility to immunoregulation (2007)

To determine the role of expanded CD4(+)CD28(null) T cells in multiple sclerosis and rheumatoid arthritis pathology, these cells were phenotypically characterized and their Ag reactivity was studied. FACS analysis confirmed that CD4(+)CD28(null) T cells are terminally differentiated effector memory cells. In addition, they express phenotypic markers that indicate their capacity to infiltrate into tissues and cause tissue damage. Whereas no reactivity to the candidate autoantigens myelin basic protein and collagen type 11 was observed within the CD4(+)CD28(null) T cell subset, CMV reactivity was prominent in four of four HC, four of four rheumatoid arthritis patients, and three of four multiple sclerosis patients. The level of the CMV-induced proliferative response was found to be related to the clonal diversity of the response. Interestingly, our results illustrate that CD4(+)CD28(null) T cells are not susceptible to the suppressive actions of CD4(+)CD25(+) regulatory T cells. In conclusion, this study provides several indications for a role of CD4(+)CD28(null) T cells in autoimmune pathology. CD4(+)CD28(null) T cells display pathogenic features, fill up immunological space, and are less susceptible to regulatory mechanisms. However, based on their low reactivity to the autoantigens tested in this study, CD4(+)CD28(null) T cells most likely do not play a direct autoaggressive role in autoimmune disease.
An Optimized BIST Architecture for FPGA Look-Up Table Testing (2006)

This paper presents a complete BIST architecture for FPGA look-up tables. This architecture can detect multiple faults, and can be configured to detect a fault in as few as five LUTs. Unlike an earlier work, our method places the output response analyzer (ORA) within the FPGA.
Concurrent Video Filming and Measuring for Visualization of Exposure (1987)

A method has been developed for simultaneous video filming and exposure measurement with a presentation of the current exposure level mixed into the picture. With the aid of special equipment, the video camera and the instruments are coupled together in such a way that the outgoing video signal will give a picture carrying superimposed information as to the current level of the exposure. It is intended to serve as an aid in the evaluation of various measures for reducing the exposure and in connection with the training of personnel performing work involving exposure. The method has been tried out for air pollutants in seven different cases where exposure to organic solvents, carbon monoxide, wood dust and fume from welding occurred. The result, in the form of a film, showed with great clarity what working operations were critical with regard to the current exposure. In one plant where the method was used in connection with spray-painting, a study was undertaken in order to see how the exposure could be reduced by simple measures. The results showed that the exposure was reduced drastically. The method is usable for air pollutants and also for other measurable environmental factors. The method is ready for use, but there are many ways in which the system could be improved. Further evaluation is also necessary.
Profile of Reported Alcohol, Tobacco, and Recreational Drug Use in Nulliparous Women (2020)

ClinicalTrials.gov, NCT01322529.
Erythrokeratodermia Congenitalis Progressiva Symmetrica (Gottron) (1970)

Research Articles| October 16 2009 Erythrokeratodermia Congenitalis Progressiva Symmetrica (Gottron) Subject Area: Dermatology , Immunology and Allergy V.K. Hopsu-Havu; V.K. Hopsu-Havu Department of Dermatology, University of Turku (Head: Prof. C. E. Sonck) Search for other works by this author on: This Site PubMed Google Scholar L. Peltonen L. Peltonen Department of Dermatology, University of Turku (Head: Prof. C. E. Sonck) Search for other works by this author on: This Site PubMed Google Scholar Dermatologica (1970) 141 (5): 321–328. https://doi.org/10.1159/000252496 Article history Received: April 16 1970 Accepted: June 24 1970 Published Online: October 16 2009 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation V.K. Hopsu-Havu, L. Peltonen; Erythrokeratodermia Congenitalis Progressiva Symmetrica (Gottron). Dermatologica 1 May 1970; 141 (5): 321–328. https://doi.org/10.1159/000252496 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsDermatology Search Advanced Search This content is only available via PDF. 1970Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Growth mechanism of Si nanowhiskers and SiGe heterostructures in Si nanowhiskers: X-ray scattering and electron microscopy investigations (2006)

Silicon nanowhiskers have been grown by molecular beam epitaxy on Si (111) by vapor-liquid-solid mechanism induced by gold droplets. Very thin Ge containing layers have been incorporated in Si nanowhiskers in order to grow SiGe heterostructures. Si and Ge growth rate in nanowhiskers, shape, and sidewall facets of nanowhiskers have been investigated by scanning electron microscopy and grazing incidence small angle x-ray scattering. Anomalous grazing incidence x-ray diffraction and transmission electron microscopy observations show a strong intermixing of Si with Ge in nanowhiskers and formation of SiGe heterostructures which are highly strained to Si.
Online Learning to Rank with Top-k Feedback (2016)

We consider two settings of online learning to rank where feedback is restricted to top ranked items. The problem is cast as an online game between a learner and sequence of users, over $T$ rounds. In both settings, the learners objective is to present ranked list of items to the users. The learner's performance is judged on the entire ranked list and true relevances of the items. However, the learner receives highly restricted feedback at end of each round, in form of relevances of only the top $k$ ranked items, where $k \ll m$. The first setting is \emph{non-contextual}, where the list of items to be ranked is fixed. The second setting is \emph{contextual}, where lists of items vary, in form of traditional query-document lists. No stochastic assumption is made on the generation process of relevances of items and contexts. We provide efficient ranking strategies for both the settings. The strategies achieve $O(T^{2/3})$ regret, where regret is based on popular ranking measures in first setting and ranking surrogates in second setting. We also provide impossibility results for certain ranking measures and a certain class of surrogates, when feedback is restricted to the top ranked item, i.e. $k=1$. We empirically demonstrate the performance of our algorithms on simulated and real world datasets.
Quarter-Sphere SVM: Attribute and Spatio-Temporal correlations based Outlier &amp; Event Detection in wireless sensor networks (2012)

Support-Vector Machines (SVM) have received a great interest in the machine learning community since their introduction, especially in Outlier Detection in Wireless Sensor Networks (WSN). The Quarter-Sphere formulation of One-Class SVM (QS-SVM), extends the main SVM ideas from supervised to unsupervised learning algorithms. The QS-SVM formulation is based only on Spatio-Temporal correlations between the sensor nodes (hence the name Spatio-Temporal Quarter-Sphere SVM, ST-QS-SVM). Thus, it has a non-ideal performance. This work presents a new One-Class Quarter-Sphere SVM formulation based on the novel concept of Attribute Correlations between the sensor nodes, hence the name, Spatio-Temporal-Attribute Quarter-sphere SVM (STA-QS-SVM) formulation. Online and partially online approaches to Outlier Detection in WSNs have been presented using this formulation. The results indicate a significant increase in the Outlier Detection rates and a remarkable reduction in the False Positive rates over the previous formulation (ST-QS-SVM). The results of this novel technique also suggest that the partially online approach is as efficient as the online approach, thereby conserving significant computational and communication complexity. Moreover very high Event Detection rates have been reported for STA-QS-SVM, which have not been reported by ST-QS-SVM.
The effect of a commercial competitive exclusion product on the selection of enrofloxacin resistance in commensal E. coli in broilers (2018)

The effect of a competitive exclusion product (Aviguard®) on the selection of fluoroquinolone resistance in poultry was assessed in vivo in the absence or presence of fluoroquinolone treatment. Two experiments using a controlled seeder-sentinel animal model (2 seeders: 4 sentinels per group) with one-day-old chicks were used. For both experiments, as soon as the chicks were hatched, the birds of two groups were administered Aviguard® and two groups were left untreated. Three days later, all groups were inoculated with an enrofloxacin-susceptible commensal E. coli strain. Five days after hatching, two birds per group were inoculated with either a bacteriologically fit or a bacteriologically non-fit enrofloxacin-resistant commensal E. coli strain. In experiment 2, all groups were orally treated for three consecutive days (days 8-10) with enrofloxacin. Throughout the experiments, faecal excretion of all inoculated E. coli strains was determined on days 2, 5, 8, 11, 18 and 23 by selective plating (via spiral plater). Linear mixed models were used to assess the effect of Aviguard® on the selection of fluoroquinolone resistance. The use of Aviguard® (P < 0.01) reduced the excretion of enrofloxacin-resistant E. coli when no enrofloxacin treatment was administered. However, this beneficial effect disappeared (P = 0.37) when the birds were treated with enrofloxacin. Similarly, bacterial fitness of the enrofloxacin-resistant E. coli strain used for inoculation had an effect (P < 0.01) on the selection of enrofloxacin resistance when no treatment was administered, whereas this effect was no longer present when enrofloxacin was administered (P = 0.70). Thus, enrofloxacin treatment cancelled the beneficial effects from administrating Aviguard® in one-day-old broiler chicks and resulted in an enrofloxacin-resistant flora. RESEARCH HIGHLIGHTS The effect of Aviguard® on the selection of enrofloxacin resistance was assessed in vivo. Without enrofloxacin, Aviguard® reduced the selection of enrofloxacin resistance. When enrofloxacin was administered, it cancelled the beneficial effect of Aviguard®.
Vitamin B<sub>6</sub> Metabolism in Chronic Kidney Disease – Relation to Transsulfuration, Advanced Glycation and Cardiovascular Disease (2009)

HD patients showed a deficiency in PLP in plasma but not in RBC. Prospective trials are needed to elucidate the potential role of elevated PA on cardiovascular and renal outcome in CKD. Vitamin B(6) supplementation might be successful in preventing AGE-related pathologies.
Molecular Analysis of Abnormal Satellite I Dna from a Buf/Mna Rat Thymoma (1993)

BUF/Mna rats develop spontaneous thymomas in an autosomal dominant manner. We constructed recombinant plasmid library of 90 and 185 base-paired (bp) satellite I DNA fragments isolated from BUF/Mna rat thymoma DNA. Four unusual clones containing 93, 95, 95, and 173 bp inserts were isolated by colony hybridization with Wistar rat satellite I DNA. Nucleotide sequence analysis of the inserts of the 4 clones revealed abnormal sequence organization and unusual subunit structure of the rat satellite I DNA. Sequence comparisons between normal and abnormal satellite I DNA suggested that the unusual subunit structure could be generated by the change of the Hinf I recognition sequence to an Eco RI cleavage site, in addition to random deletions, insertions and base substitutions. The heptanucleotide sequence TGGGAAC, which is strictly conserved in normal subunits, was completely lost in all these clones. Southern blot hybridization revealed the amplification of abnormal satellite I DNA in BUF/Mna rat thymomas.