gebhart/patrepeval huggingface dataset:
New Regio- and Stereocontrolles Reactions of 2-Vinylindoles with CC-Dienophiles: Diels-Alder Reactions, Ene Reactions and Michael Additions (1988)

The reactions of selectively functionalieed 2-vinylindoles with some acyclic and cyclic CC-dienophiles yield Diels-Alder adducts, Diels-Alder ene products, and Michael adducts, respectively, with very high regio-and/or stereoselectivities.This methodology provides a convenient access to functionalized indoles, carbaeoles, and [c]pyrroloannellated carbaeoles with substitution patterns that are not so easily accessible by other routes.Diels-Alder reactions of vinylindoles have been found by and by ~s ~, ~-~t o represent a synthetically very attractive concept for the preparation of novel [blannellated indoles to serve as lead substances and as building blocks for alkaloids.However, the synthetic potential and limitations of the concept, as well as the analytical methodology required by the alternative reaction pathways, especially when 2-vinylindales are used, have not yet been sufficiently delineated to allow use of the concept in the planning of syntheses of condensed heterocy-~l e s 4 -~.Thus, in continuation of our synthetic investigations on vinylheterocycles, we now report on some new and interesting reactions of selected, principally donor-and acceptor-substituted, 2-vinylindoles 1 with acyclic and cyclic CCdienophiles and, at the same time, illustrate the competing reaction pattern of "Diels-Alder reaotion, Diels-Alder ene reaction, and Michael a d d i t i ~n " ~' ~.This pattern is markedly less frequently found in such a state of completeness in the 3-vinylindole series4.In the present communication on the reactions of la-i with methyl propynoate, methyl acrylate, 1-phenylmaleimide, 1-penten-?-one,and p-beneoquinone, only those combinations of reactants are discussed which, in our studies, produced a clear and structural-analytically perceivable reaction result.
The Unchanging Incidence and Case-Fatality of Stroke in the 1990s (2006)

Despite advances in stroke prevention treatments during the 1990s, the incidence of hospitalized stroke did not decrease within our population. Case-fatality also did not change between study periods. Excess stroke mortality rates seen in blacks nationally are likely the result of excess stroke incidence and not case-fatality, and the racial disparity in stroke incidence did not change over time.
Concerning the Photolysis of the Sodium Salt of (Δ2-2,3-Diphenylcyclopropenyl)carboxaldehyde Tosylhydrazone (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConcerning the Photolysis of the Sodium Salt of (Δ2-2,3-Diphenylcyclopropenyl)carboxaldehyde TosylhydrazoneSatoru Masamune and Masahiko KatoCite this: J. Am. Chem. Soc. 1966, 88, 3, 610–611Publication Date (Print):February 1, 1966Publication History Published online1 May 2002Published inissue 1 February 1966https://pubs.acs.org/doi/10.1021/ja00955a043https://doi.org/10.1021/ja00955a043research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Use of the 2-μm cw laser as addition and/or alternative for the Nd:YAG in urology (2007)

Recently, 2 &mgr;m cw laser systems have been introduced for surgery. The 2 &mgr;m wavelength is predominantly absorbed by water and enables effective cutting and ablation of tissue similar to the cw CO<sub>2</sub> laser. In contrast to the CO<sub>2</sub> laser, the 2 &mgr;m wavelength is delivered through fiber optics and available for endoscopic procedures. After many years of experience with the 1.06 &mgr;m Nd:YAG laser, we started to use the 2 &mgr;m cw laser as alternative for various urological treatments. The treatments strategies and optimal settings were examined in the lab comparing the two 1.06 and 2 &mgr;m wavelengths performing thermal measurements. Consequently, the laser was applied for various urological cases. Penile tumors were resected with haemostatic effects and good aesthetic healing comparable with the Nd:YAG laser. Although the Nd:YAG has initially a deeper penetration, the blackening of the fiber during tissue cutting, provides a more superficial effect like the 2 &mgr;m laser. Bladder (pre)malignancies were ablated after biopsy. Only with higher stage tumors, coagulation depth of the Nd:YAG might be preferable for adequate treatment. Strictures in the urethra were incised and stents were effectively desobstructed: one patient with a stent implanted after a pelvic trauma, and one patient with catheterizable apedico stoma stenoses. The thermal damage during incision to deeper layers is minimal so recurrence due to scarring is not expected. Also hair grow in patients who underwent urethroplasty was effectively treated and scrotal atheromata cysts were effectively resected without recurrence. Laparoscopic nefrectomies are being considered using the 2 &mgr;m cw laser. The 2 &mgr;m cw laser has shown to be a versatile instrument for effective treatment of various urological indications. More patients and long term results are needed to prove the clinical significance compared to other treatment modalities
From acetone metalation to the catalytic α-arylation of acyclic ketones with NHC–nickel(ii) complexes (2014)

Air-stable N-heterocyclic carbene-nickel(ii) complexes at concentrations as low as 1 mol% exhibit high catalytic activity for the α-arylation of acyclic ketones and join a highly restricted list of nickel catalysts for this key reaction. Mechanistic investigations suggest a radical pathway.
Design of Networks-on-Chip for Real-Time Multi-processor Systems-on-Chip (2012)

This paper addresses the design of networks-on-chips for use in multi-processor systems-on-chips - the hardware platforms used in embedded systems. These platforms typically have to guarantee real-time properties, and as the network is a shared resource, it has to provide service guarantees (bandwidth and/or latency) to different communication flows. The paper reviews some past work in this field and the lessons learned, and the paper discusses ongoing research conducted as part of the project "Time-predictable Multi-Core Architecture for Embedded Systems" (T-CREST), supported by the European Commissions seventh framework programme. The aim of this project is to develop a general-purpose multi-core platform for real-time systems as well as tools supporting its use (compiler, simulator, and worst-case execution time analysis tool).
ChemInform Abstract: Synthesis, Dopamine and Serotonin Transporter Binding Affinities of Novel Analogues of Meperidine. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Branched-Chain Amino Acids as New Biomarkers of Major Depression - A Novel Neurobiology of Mood Disorder (2016)

Our study results are strong evidence that in patients with major depression, BCAAs might be appropriate biomarkers for depression. Reduced activation of the mammalian target of rapamycin (mTor) due to a reduction of BCAAs might play a crucial unrecognised factor in the etiology of depression and may evoke depressive symptomatology and lower energy metabolism in patients with major depression. In the future, mTor and its up- and downstream signalling partners might be important targets for the development of novel antidepressants.
Lasing from InGaP quantum dots in a spin-coated flexible microcavity (2008)

We report the realization of a mechanically flexible microcavity laser emitting at 657 nm using spin coating. These optically pumped vertical cavity surface emitting lasers use InGaP colloidal quantum dots as the active medium and alternating polymer layers of different refractive indices as the Bragg mirrors. Results of photoluminescence measurements indicating enhancement in spontaneous emission are presented. We also demonstrate the possibility of peeling the device off the substrate yielding a flexible structure that can conform to any shape and whose emission spectra can be mechanically tuned. This new class of hybrid lasers combines advantages of organic and inorganic materials.
Abrogation of taxol-induced G2-M arrest and apoptosis in human ovarian cancer cells grown as multicellular tumor spheroids. (1997)

Tumor cells grown as multicellular spheroids are known to be intrinsically more resistant to a large and diverse array of anticancer chemotherapeutic drugs compared to the same cells grown as dispersed monolayer cell cultures. Some drugs, however, seem relatively insensitive to this multicellular drug resistance, e.g., cisplatinum. Whether the cytotoxic effects of Taxol, an anticancer drug of growing importance in the treatment of breast and ovarian carcinomas, are diminished by multicellular growth conditions is unknown. To study this question, we examined the relative sensitivity of a panel of four different human ovarian carcinoma cell lines to either Taxol or cisplatinum. Upon exposure to Taxol, all the cell lines manifested a relative drug-resistant phenotype when grown as multicellular tumor spheroids, compared to the same cells grown as sparse monolayer cultures. This multicellular-dependent drug-resistant phenotype was not observed when the same cells were exposed to cisplatinum for an equivalent length of time. Monolayer but not spheroid cultures exposed to Taxol demonstrated an accumulation of cells at G2-M and a sub-G1 apoptotic region. In addition, Taxol-induced apoptosis was detected in monolayer conditions but not in the spheroid cultures. The relative sensitivity of the monolayer cell cultures was associated with a decrease in bcl-X(L) protein levels after Taxol exposure, an effect not observed in drug-exposed spheroids. Taken together, these results suggest that some aspects of intrinsic Taxol resistance in ovarian carcinoma may be due to multicellular-dependent or -associated mechanisms. This raises the possibility of using antiadhesive agents to reverse multicellular-dependent Taxol resistance in certain circumstances as a potential means of increasing the initial efficiency of Taxol therapy against ovarian carcinoma.
Recognition of Escherichia coli attTn7 by transposon Tn7: lack of specific sequence requirements at the point of Tn7 insertion (1988)

Transposon Tn7 inserts at high frequency into a specific site in the Escherichia coli chromosome called attTn7. We show that the point of Tn7 insertion in attTn7 lies within the transcriptional terminator of the bacterial glmS gene. We have exploited the glmS transcription terminator to isolate mutants with altered sequences at the point of Tn7 insertion and have used these mutants to show that the nucleotide sequence at the point of Tn7 insertion is irrelevant to attTn7 target activity. Thus, the nucleotides which provide attTn7 target activity are distinct from the point of Tn7 insertion. We have also examined the effect of transcription on the capacity of attTn7 to act as a target for Tn7 transposition. Our results suggest that transcription of attTn7 does not modulate its Tn7 target activity.
RUL prognostics and critical zone recognition for suspended time-series (2015)

Prognostic systems are expected to provide predictive information about the Remaining Useful Life (RUL) for equipment and components. During the last ten years, numerous RUL prediction models have been developed. These methods usually treat completed time-series only, i.e. full statistics before the item fails. Under actual operating conditions occasionally number of failed items is too small, and therefore application of uncompleted (suspended) time-series is necessary, and using Semi-Supervised methods instead of Supervised is required. In this paper, we propose an approach based on regression and classification models we have introduced in the past [1, 2]. These models consider monitoring data (time-series) as inputs and RUL estimation as output. Significant difference of this model is using suspended time-series to estimate optimal RUL for each suspended time-series, so they can be used for initial model training. This article describes the procedures that have been developed and applied successfully for Suspended Time-Series using. Several models based on modification of the SVR and SVC methods (Support Vector Regression and Support Vector Classification) are proposed for consideration. Number of uncompleted time-series used for training and cross-validation is proposed as additional control parameter. Suggested methodology and algorithms were verified on the NASA Aircraft Engine database. Numerical examples based on this database have been also considered. Experimental result shows that the proposed model performs significantly better estimations than pure supervised learning based model.
Adverse reactions to bendrofluazide and propranolol for the treatment of mild hypertension. Report of Medical Research Council Working Party on Mild to Moderate Hypertension. (1981)

Participants in the Medical Research Council treatment trial for mild hypertension are randomly allocated to one of four treatment groups: bendrofluazide, propranolol, or a placebo for either of these drugs. The trial is single-blind. 23 582 patient-years of observation have been completed so far, 10 684 on active drugs and 12 898 on placebos. The results show an association between bendrofluazide treatment and impotence, and impotence also occurred more frequently in patients taking propranolol than in those taking placebos. Other adverse reactions significantly linked with active drugs include impaired glucose tolerance in men and women and gout in men, associated with bendrofluazide treatment, and Raynaud's phenomenon and dyspnoea in men and women taking propranolol. No corneal disease is known to have occurred in the propranolol group. Mean serum potassium level fell, and urea and uric acid levels rose, in men and women taking bendrofluazide. In the propranolol group, serum potassium and uric acid levels rose in both sexes, but the urea level rose significantly in women only.
Patient Satisfaction with Complete Denture Prosthesis Made By Clinical Year Students at the Faculty of Dentistry, Al Azhar University - Gaza (2020)

Objective: Patients' satisfaction is one of the most important goals in complete denture therapy, and there are many factors influencing this parameter. This study aimed to determine patient satisfaction with conventional removable complete denture made by clinical year students at the Faculty of Dentistry, Al Azhar University - Gaza. Methods: A sample of 85 patient who had conventional removable complete denture made by clinical year students at the Faculty of Dentistry Al Azhar University - Gaza filled a questionnaire two months after denture insertion. The questionnaire involving four sections including personal information, history, denture evaluation in aspects of mastication, speech, aesthetics and retention, and patient comfort. Results: Of the 85 patient studied, 81% were males, and the mean age was 60.3 years SD+-9.64. The majority (n= 67, 79 %) lost their teeth because of bad oral hygiene. The overall satisfaction level was (92.1%), and patients were more satisfied with their upper denture. A significant association was found between the patient satisfaction and prior denture use experience (p=0.013). No significant correlation was established between the patient satisfaction and their gender (p=0.188), age group (p=0.640) and employment status (p=0.667).Conclusion: The patients have shown a high level of overall satisfaction. A significant association was found between the overall satisfaction level of patients and prior denture use experience. No statistically significant association was observed between the overall satisfaction level of patients and with each of age group, employment status and gender.
Use of a Biodegradable Chlorhexidine Chip in the Treatment of Adult Periodontitis: Clinical and Radiographic Findings (2000)

These data indicate that the CHX chip, when used as an adjunct to scaling and root planing, significantly reduces loss of alveolar bone.
Novel method for imaging high-power CO 2 laser beams (2003)

Continuous monitoring of high power (above 2 kW) CO<sub>2</sub> laser beams with camera based systems has not been effective because beam sampling optics have not been available. Camera based systems allow real-time imaging of the entire beam profile which in turn enables real-time tuning and alignment of the laser, as well as enabling instantaneous recognition of beam misalignment in the optical delivery train. Spiricon and II-VI have jointly developed a new method for in-line, passive sampling and beam profiling of high power, multi-kilowatt CO<sub>2</sub> lasers. The system uses conventional optics in a novel sampling arrangement, coupled to a Spiricon Pyroelectric IR Camera and Laser Beam Analysis software.
Ultra-long lived atomic polarization of Rb confined in hypocycloidal Kagome HC-PCF (2014)

We measure atomic polarization relaxation-time of Rb-loaded in different hypocycloidal-core Kagome HC-PCFs. The measured relaxation-time is two-orders of magnitude larger than the transit-time limit. We attribute this to slow-atom stronger contribution to the polarization build-up.
Realization of a multiple resonant DC-link converter (2003)

The realization of a passively clamped resonant DC-link converter containing both a three-phase controlled rectifier and a DC-motor drive is presented. The control electronics are described, and current and voltage waveforms are presented for documentation of the passively clamped converter. A passively clamped resonant DC-link converter with an oscillating link frequency of 65 kHz was realized in the laboratory, using insulated-gate bipolar transistors (IGBTs). The three-phase converter uses two current modulation methods, modified current regulated delta modulation (MCR Delta M) and current regulated delta modulation (CR Delta M). Both modulation methods are realized with analog electronics: MCR Delta M uses an electrically programmable read-only memory (EPROM). MCR Delta M is the most intelligent modulation method which restricts the changes of switch state in order to minimize the clamp energy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Expanding Boundaries - Comparison of District Heating Systems and Distributed Geothermal Network for Optimal Exergetic Performance – P.M. Falk, F. Meggers, P. Stephan, F. Dammel (2016)

Sustainability, Urban Energy Systems, Spatial Energy Planning, Renewable Energy, Urban Design, Energy Hub, Urban Planning, Renovation Strategy, Sustainable Architectural Design, Building Material, Eco-Efficiency, Material Efficiency Expanding Boundaries
Search method for equilibrium states of supply chain using genetic algorithm and replicator dynamics (2022)

サプライチェーンの各利害関係者をエージェントとしてゲームモデル化し，様々なシナリオを想定して均衡状態を求めることは，制度や企業間での契約の検討に役立つと考えられる．ゲームの均衡を導出する手法としてレプリケーターダイナミクス（RD）があるが，エージェントが持つ戦略数の増加に伴い計算負荷が課題となる．本稿では現実的な問題への適用を想定し，遺伝的アルゴリズムとRDを融合した効率的な均衡探索方法を提案した．商品取引をモデル化した例題について，RDを用いた場合とほぼ同じ均衡をRDより短い時間で求めることができた．
Advanced sensor platform for human detection and protection in autonomous farming (2015)

The concept of autonomous farming concerns automatic agricultural machines operating safely and efficiently without human intervention. In order to ensure safe autonomous operation, real-time risk detection and avoidance must be performed. This paper presents a flexible vehicle-mounted sensor platform for recording positional and imaging data with a total of seven sensors. Different imaging modalities are chosen for robust detection performance in a variety of weather and lighting conditions. Different algorithms applied to recordings from a grass-harvesting case study show that it is possible to detect humans, whereas small animals located in front of the vehicle represent a much greater challenge.
Influence of Bis-GMA Derivative Monomer-Based Particulate Composite Resins on the Cuspal Deformation and Microleakage of Restored Teeth (2010)

The development of novel Bis-GMA derivatives incorporated as base monomers in resin-based composites (RBCs) may offer a potential reduction in polymerization stresses generated in the tooth/restoration complex compared with conventional Bis-GMA. The hypothesis of the current study was that RBCs based on either a urethane derivative of Bis-GMA (Bis-GMA1) or a Bis-GMA superior oligomer (Bis-GMA2) would produce less cuspal deformation and less cervical enamel microleakage than RBCs based on a conventional Bis-GMA. Standardized MOD cavities were prepared in extracted upper premolars (n = 9) and restored with each of the three experimental RBCs. The cuspal deformation of premolars was recorded during and post-irradiation using direct current differential transformer (DCDT) displacement transducers, and data were analyzed using Kruskal–Wallis and Mann–Whitney tests at a p < 0.05 level of significance. The polymerization process of the three RBCs determined cuspal extension during exposure to irradiation, followed by cuspal deflection when the light source was turned off. Both composites containing Bis-GMA derivative monomers were determined to result in significantly reduced cuspal extension compared to the composite based on Bis-GMA. Only the composite based on Bis-GMA2 monomer generated a significantly reduced cuspal deflection compared to the composite based on Bis-GMA. No dye penetration was detected at the cervical enamel margin of any restoration.
Functional MRI with simultaneous EEG recording: Feasibility and application to motor and visual activation (2001)

The possibility of combining the high spatial resolution of functional magnetic resonance imaging (fMRI) with the high temporal resolution of electroencephalography (EEG) may provide a new tool in cognitive neurophysiology, as well as in clinical applications such as epilepsy. However, the simultaneous recording of EEG and fMRI raises important practical problems: 1) the patients' safety, in particular the risk of skin burns due to electrodes heating; 2) the impairment of the EEG recording by the static magnetic field, as well as by RF and magnetic field gradients used during MRI; and 3) the quality of MR images, which may be affected by the presence of conductors and electronic devices in the MRI bore. Here we present our experiences on 19 normal volunteers who underwent combined fMRI and 16-channel EEG examination. Consistent with previous reports, safety could be assured when performing EEG recordings during fMRI acquisition. Electrophysiological signals recorded with surface EEG were similar inside and outside the 1.5 T magnet. Furthermore, fMRI using motor or visual tasks revealed similar areas of activation when performed with and without 16-channel EEG recording. J. Magn. Reson. Imaging 2001;13:943-948.