gebhart/patrepeval huggingface dataset:
An atomistic method for slow structural deformations (2009)

We investigate the feasibility of applying a recent algorithm for sampling activation barriers in supercooled liquids to probe activated kinetics of solid-state deformation under stress. The basis for exploring this isomorphism is that the elementary processes of activation and relaxation in potential energy space are valid for any bulk system. Since the method is able to explain shear relaxation over a range of temperatures, it seems reasonable to expect the approach also can be useful for studying structural deformation over a range of applied stresses. We present preliminary results on time-dependent deformation of nanocrystalline structures to suggest a new way to probe structural relaxation at slow strain rates that retains atomistic details of individual and collective rearrangements.
Robust Minimum $\ell_{1}$-Norm Adaptive Beamformer Against Intermittent Sensor Failure and Steering Vector Error (2010)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A robust adaptive beamformer is described to mitigate against steering vector error and intermittent sensor(s) failure which exists in the form of impulsive noise in the received signal of failed sensor(s). This new beamformer iteratively minimizes the <formula formulatype="inline"><tex Notation="TeX">$\ell_{1}$</tex> </formula>-norm of the beamformer's output, subject to a prespecified set of quadratic constraints which target on attenuating the influence caused by steering vector error. To solve the proposed optimization problem, gradient descent algorithm is adopted. The choice of the Lagrange multiplier <formula formulatype="inline"><tex Notation="TeX">$\lambda$</tex></formula> as well as the adaptive step-size <formula formulatype="inline"><tex Notation="TeX">$\mu(k)$</tex> </formula> are derived in detail. Simulation results verify validity and advantages of the proposed algorithms over some existing methods. </para>
Structure Design and Simulation Analysis of MEMS Ring Vibrating Gyroscope (2018)

A novel MEMS ring vibrating gyroscope with S springs is proposed, and the working principle, vibrating characteristics and sensitive working mode are analyzed, according to the working mechanism and vibrating characteristics of axially symmetric ring vibrating gyroscope. On this basis, the finite element model of the ring vibrating gyroscope is established by using ANSYS. Furthermore, the modal analysis, harmonic response analysis, impact transient analysis and static analysis is performed. The results of simulation and analysis show that the natural frequency difference between the driving and sensing mode is 1Hz and the minimum frequency difference between the working mode and other vibrating modes is 3304Hz, which can effectively resist the interference of environmental vibration. The maximum stress of the resonant structure is 104.46MPa under the transient influence of 10 000g, which can work stably.
The use of Pulse Compression and Frequency Modulated Continuous Wave to improve Ultrasonic Non Destructive Evaluation of highly-scattering materials (2014)

Different approaches have been investigated for the transmission of signals through highly attenuating and scattering materials. Chirp signals are sent through the material, and then processed using either time-multiplication or cross-correlation with a template to obtain information concerning the sample. The use of both narrow bandwidth piezoelectric transducers and wide bandwidth piezocomposites is also discussed.
Second trimester amniotic fluid cytokine concentrations, Ureaplasmasp. colonisation status and sexual activity as predictors of preterm birth in Chinese and Australian women (2014)

Second trimester amniocentesis for measurement of inflammatory markers and Ureaplasma sp. DNA was not indicative of risk of preterm birth, at least in these populations. The lower rate of preterm birth in China was not explained by differences in amniotic fluid inflammatory markers, Ureaplasma sp. colonisation, or sexual activity.
Nanomedicine In Focus: Opportunities and Challenges Ahead (2012)

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ISOLATION AND SOME CHEMICAL PROPERTIES OF ASPERMATOGENIC SUBSTANCE FROM BULL SEMINAL VESICLE FLUID (1973)

Summary. Aspermatogenic substance (AS) was isolated from bull seminal vesicle fluid by precipitation with acetic acid and ammonium sulphate, and subjected to CM Sephadex C-50 and Sephadex G-100 column chromatography. The molecular weight of the monomer of AS was 22,000 and of the dimer was 44,000 as determined by gel filtration. The purity of the AS was controlled by disc electrophoresis in acrylamide gel, starch-gel electrophoresis, immunoelectrophoresis in agar gel, by peak homogeneity at the last step of separation and by the ultracentrifugation pattern. The N-terminal amino acid was lysine. The absorbance of 0·1% AS at 280 nm in pH 5·5 buffer was 0·510. The s value obtained for 0·5% AS solution was 2·7.
Folding funnels and binding mechanisms (1999)

The long-held views on lock-and-key versus induced fit in binding arose from the notion that a protein exists in a single, most stable conformation, dictated by its sequence. However, in solution proteins exist in a range of conformations, which may be described by statistical mechanical laws and their populations follow statistical distributions. Upon binding, the equilibrium will shift in favor of the bound conformation from the ensemble of conformations around the bottom of the folding funnel. Hence here we extend the implications and the usefulness of the folding funnel concept to explain fundamental binding mechanisms.
Measurements of angular evaporation characteristics of sources (1983)

An apparatus is described for the rapid and reliable measurement of the angular evaporation characteristics of sources. It consists of a moving and a stationary quartz crystal evaporation rate monitor, and it can be operated at any chosen azimuth angle. The instrument has been used to demonstrate the effect of source design, rate of evaporation, external obstructions, and evaporant material on the angular evaporation characteristics of high rate, high capacity evaporation sources.
Eliminating abnormal positioning bias with translation technology in AGPS method (2010)

Abnormal positioning bias were found through the analysis to positioning algorithm in assisted global positioning system (AGPS) with mobile station (MS) clock error. This bias is engendered in the process of calculating the pseudo-range. The translation number of whole chips is determined which is referred to the satellite of maximum angle of elevation relative to the base station (BS). Using this method, the abnormal positioning bias of several hundred kilometers was eliminated.
La cáscara de nuez... y un poquito de universo (2002)

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high mortality, and the efficacy of monotherapy for TNBC is still disappointing. Here, we developed a novel combination therapy for TNBC based on a multifunctional nanohollow carbon sphere. This intelligent material contains a superadsorbed silicon dioxide sphere, sufficient loading space, a nanoscale hole on its surface, a robust shell, and an outer bilayer, and it could load both programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) small-molecule immune checkpoints and small-molecule photosensitizers with excellent loading contents, protect these small molecules during the systemic circulation, and achieve accumulation of them in tumor sites after systemic administration followed by the application of laser irradiation, thereby realizing dual attack of photodynamic therapy and immunotherapy on tumors. Importantly, we integrated the fasting-mimicking diet condition that can further enhance the cellular uptake efficiency of nanoparticles in tumor cells and amplify the immune responses, further enhancing the therapeutic effect. Thus, a novel combination therapy "PD-1/PD-L1 immune checkpoint blockade + photodynamic therapy + fasting-mimicking diet"was developed with the aid of our materials, which eventually achieved a marked therapeutic effect in 4T1-tumor-bearing mice. The concept can also be applied to the clinical treatment of human TNBC with guiding significance in the future.
Novel multifunctional RKKY coupling layer for ultrathin perpendicular synthetic antiferromagnet (2018)

A novel multi-functional antiferromagnetic coupling layer (MF-AFC) combining Ru and W is revealed to realize an extremely thin (3.8 nm), back-end-of-line compatible as well as magnetically and electrically stable perpendicular synthetic antiferromagnetic layer (pSAF), essential for spintronic memory and logic device applications. In addition to achieving antiferromagnetic RKKY coupling, this MF-AFC also acts as a Boron sink and texture-breaking layer. A detailed optimization of the thickness of the various involved layers has been carried out to obtain extremely thin-pSAF reference layer with stable magnetic properties, which enables the realization of sub-20 nm STT-MRAM cells. Two important advantages are provided by this ultrathin reference layer: the easing of the reference layer etching and the minimization of the dipolar field acting on the storage layer magnetization.
On Penicillin‐Binding Protein 1b Affinity‐Labeling Reagents (2003)

Abstract The synthesis of some 3‐aryl‐3‐(trifluoromethyl)3 H ‐diazirine and benzophenone‐based photoaffinity labels is reported. The photolabile group is bound to a scaffold that also accommodates functional groups to which an indicator unit (biotin) and the bioactive ligand can be attached orthogonally. To three of the labels, moenomycin was conjugated with the aim to provide tools for the identification of the moenomycin binding site within the transglycosylase domain of the enzyme PBP 1b. Some preliminary photoaffinity‐labeling experiments were carried out.
Dysbiosis in a canine model of human fistulizing Crohn’s disease (2019)

ABSTRACT Background Crohn’s disease (CD) is a chronic immune-mediated inflammatory condition caused by the loss of mucosal tolerance towards the commensal microbiota. Approximately 70% of CD patients experience perianal complications. Perianal fistulizing is a predictor of poor long-term outcomes. Animal models of gut inflammation have failed to fully recapitulate the human manifestations of fistulizing CD. Here, we evaluated dogs with spontaneous canine anal furunculosis (CAF), a disease with clinical similarities to fistulizing CD, as a surrogate model for human fistulizing CD. Results By comparing the gut microbiomes between dogs suffering from CAF (CAF dogs) and healthy dogs, we show that similar to microbiome population trends in CD humans, CAF dogs microbiomes are either very dissimilar (dysbiotic) or similar, yet unique, to healthy dog’s microbiomes. Compared to healthy or healthy-like CAF microbiomes, dysbiotic CAF microbiomes showed an increased abundance of Bacteroides vulgatus and Escherichia coli and a decreased abundance of Megamonas species and Prevotella copri . These same determinant bacteria are associated with human CD. Conclusions Our results highlight the similarities in microbiome community patterns between CAF dogs and CD humans, including overlapping determinant bacterial taxa, and support the use of CAF dogs as a surrogate model to study human fistulizing CD.
A Pathway for Information Transmission to the Inner Ear (1992)

The use of cochlear implants as an aid to neurosensory deafness is becoming an established procedure. The transmission of a processed speech signal is accomplished either transcutaneously via radiofrequency or percutaneously by connector coupling. Whereas the former is sensitive to electromagnetic interference, the latter increases the risk of infection. To overcome these disadvantages, an infrared (IR) system for transmission through the tympanic membrane was devised and tested. The transmitter/receiver consisted of an IR light emitting diode (LED; 920 nm) and a photovoltaic cell. The LED was placed inside the auditory canal of four dogs and the photovoltaic cell in the tympanic cavity over the cochlear promontory. A sinusoidal signal modulation was applied to the LED. The emitted signal was detected undistorted after crossing the tympanic membrane, with an average absorbance of 20%. High frequency cut-off was adequate for cochlear implant purposes and audio prosthetic devices in general. The authors conclude that the tympanic membrane may be used as a translucent sealed interface to transmit data in the audio range to the middle and inner ears, with small power loss, good frequency response, and immunity to interference.
Time-Equivariant Contrastive Video Representation Learning (2021)

We introduce a novel self-supervised contrastive learning method to learn representations from unlabelled videos. Existing approaches ignore the specifics of input distortions, e.g., by learning invariance to temporal transformations. Instead, we argue that video representation should preserve video dynamics and reflect temporal manipulations of the input. Therefore, we exploit novel constraints to build representations that are equivariant to temporal transformations and better capture video dynamics. In our method, relative temporal transformations between augmented clips of a video are encoded in a vector and contrasted with other transformation vectors. To support temporal equivariance learning, we additionally propose the self-supervised classification of two clips of a video into 1. overlapping 2. ordered, or 3. unordered. Our experiments show that time-equivariant representations achieve state-of-the-art results in video retrieval and action recognition benchmarks on UCF101, HMDB51, and Diving48.
Comparative Resistance of Phage Isolates of Four Genotypes of F-Specific RNA Bacteriophages to Various Inactivation Processes (2002)

The effect of natural inactivation in freshwater, chlorination, ammonia, extreme pHs, temperature, and salt content on phage inactivation was evaluated on mixtures of F-specific RNA bacteriophage isolates belonging to genotypes I, II, III, and IV. The bacteriophages studied were previously but recently isolated from natural samples, characterized as F-specific RNA bacteriophages and genotyped by plaque hybridization with genotype-specific probes. Natural inactivation in river water was modeled by in situ incubation of bacteriophages inside submerged dialysis tubes. After several days bacteriophages of genotype I showed the highest persistence, which was significantly different from that of bacteriophages of genotype II, IV, or III. The pattern of resistance of phages belonging to the various genotypes to extreme pHs, ammonia, temperature, salt concentration, and chlorination was similar. In all cases, phages of genotype I showed the highest persistence, followed by the phages of genotypes II, III, and IV. The phages of genotypes III and IV were the least resistant to all treatments, and resistance of genotypes III and IV to the treatments was similar. Bacteriophages of genotype II showed intermediate resistance to some of the treatments. The resistance of four phages of genotype I to natural inactivation and chlorination did not differ significantly. These results indicate that genotypes III and IV are much more sensitive to environmental stresses and to treatments than the other genotypes, especially than genotype I. This should be taken into consideration in future studies aimed at using genotypes of F-specific RNA bacteriophages to fingerprint the origin of fecal pollution.
Premorbid BMI predicts binge‐purge symptomatology among individuals with anorexia nervosa (2017)

Among individuals who develop an eating disorder, premorbid BMI may be implicated in the type and course of the eating disorder that emerges.
Glaucoma Diagnostic Ability of Layer-by-Layer Segmented Ganglion Cell Complex by Spectral-Domain Optical Coherence Tomography (2016)

The diagnostic ability of segmented mRNFL and GCL to discriminate between normal and glaucoma eyes is high and comparable to that of cpRNFL thickness. The measurement and monitoring of GCL could be a practical and effective approach to glaucoma diagnostics.
pH-Dependent Association of Proteins. The Test Case of Monoclonal Antibody HyHEL-5 and Its Antigen Hen Egg White Lysozyme (2009)

We describe a method for determining diffusion-controlled rate constants for protein-protein association that explicitly includes the solution pH. The method combines the transient-complex theory for computing electrostatically enhanced association rates with an approach based on a rigorous thermodynamic cycle and partition functions for energy levels characterizing protonation states of associating proteins and their complexes. To test our method, we determine the pH-dependent kinetics of association of the HyHEL-5 antibody with its antigen hen egg white lysozyme. It was shown experimentally that their association rate constant depends on pH, increasing linearly in the pH range 6-8 and saturating or even exhibiting a flat maximum in the pH range 8-10. The presented methodology leads to a qualitative agreement with the experimental data. Our approach allows one to study diffusion-controlled protein-protein association under different pH conditions by taking into account the ensembles of protonation states rather than just the most probable protonation state of each protein.
Inaugural Conference on Incorporating Patient-Reported Outcomes and Patient Preference Information into Clinical Research, Clinical Care, and Risk-Benefit Assessments for Neurodegenerative Diseases (2017)

in Washington, DC, USA, brought together a diverse group of patients and their families, academia, government [US Food and Drug Administration (FDA), National Institutes of Health (NIH)], and industry to discuss patient-reported outcomes (PROs) and patient preference information (PPI) measures in research, clinical practice, and regulatory decision-making. Many stakeholders and their organizations have advocated for the inclusion of patients' perspectives in clinical care, research, and regulatory decisions. The consensus is that PROs and patient preferences are important and necessary to inform the decisions that are made by healthcare providers, patients, and their families, as well as the information collected by researchers and medical product manufacturers and reviewed by regulators in the development of medical products
BIMBINGAN DAN KONSELING ISLAM DENGAN TERAPI SILATURAHMI PADA SEORANG REMAJA YANG MENGALAMI DEPRESI (2014)

This study revealed the process of implementation of Islamic Guidance and Counseling with relationship therapy in an adolescent with depression. This study used qualitative methods with qualitative descriptive analysis. Data collection techniques used observation, interview and documentation to find the facts of the condition of a depressed teenager. Process of Islamic Guidance and Counseling with relationship therapy that counselors perform a variety of outreach activities, conversations and approaches with family and close friends counselee counselee to find out about the problems and conditions of the counselee . In addition , counselors also ask close friends help counselees to participate in providing assistance to the counselee to get out of the problems faced , because usually teens have a tendency to share feelings with peers . In this study concluded that the process of Islamic Guidance and Counseling with relationship therapy is quite successful with a percentage of 60 % , which these results can be seen from the change in attitude or behavior of the counselee who initially locked himself in the house into a venture out of the house. Keywords : Guidance and Counseling Islam , Gathering , Depression
Efficient heterogeneous three-dimensional packaging at a system level (2002)

While a proliferation of approaches have been proposed for three-dimensional packaging, a basic dichotimization between short stacks of regular (low-complexity) iterated assemblies and heterogeneous approaches exist. For the latter, no clear order exists, which has stifled the true acceptance of three-dimensional packaging. Barriers to advancement of heterogeneous are discussed. Two basic approaches are examined.
Upper Extremity Functional Evaluation by Fugl-Meyer Assessment Scoring Using Depth-Sensing Camera in Hemiplegic Stroke Patients (2016)

Virtual home-based rehabilitation is an emerging area in stroke rehabilitation. Functional assessment tools are essential to monitor recovery and provide current function-based rehabilitation. We developed the Fugl-Meyer Assessment (FMA) tool using Kinect (Microsoft, USA) and validated it for hemiplegic stroke patients. Forty-one patients with hemiplegic stroke were enrolled. Thirteen of 33 items were selected for upper extremity motor FMA. One occupational therapist assessed the motor FMA while recording upper extremity motion with Kinect. FMA score was calculated using principal component analysis and artificial neural network learning from the saved motion data. The degree of jerky motion was also transformed to jerky scores. Prediction accuracy for each of the 13 items and correlations between real FMA scores and scores using Kinect were analyzed. Prediction accuracies ranged from 65% to 87% in each item and exceeded 70% for 9 items. Correlations were high for the summed score for the 13 items between real FMA scores and scores obtained using Kinect (Pearson's correlation coefficient = 0.873, P<0.0001) and those between total upper extremity scores (66 in full score) and scores using Kinect (26 in full score) (Pearson's correlation coefficient = 0.799, P<0.0001). Log transformed jerky scores were significantly higher in the hemiplegic side (1.81 ± 0.76) compared to non-hemiplegic side (1.21 ± 0.43) and showed significant negative correlations with Brunnstrom stage (3 to 6; Spearman correlation coefficient = -0.387, P = 0.046). FMA using Kinect is a valid way to assess upper extremity function and can provide additional results for movement quality in stroke patients. This may be useful in the setting of unsupervised home-based rehabilitation.
Predictors of Cognitive Decline in Older Adult Type 2 Diabetes from the Veterans Affairs Diabetes Trial (2016)

A 5-year period of randomized INT glucose-lowering did not significantly reduce the rate of cognitive decline in older-aged adults with type 2 diabetes. Systolic and diastolic BPs as well as plasma triglycerides appeared as modifiable risk factors of the rate of cognitive decline in older adult type 2 diabetes.
Excitation Power Dependence of Al-Related Features in the LTPL Spectra of 4H-SiC (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Detection of ganglioside GM2 in sera and tumor tissues of hepatoma patients. (1987)

GM2 ganglioside was detected in all five sera of hepatoma patients analyzed by thin-layer chromatography in conjunction with enzyme-immunostaining with rabbit anti-GM2 antibody and horseradish peroxidase-conjugated anti-rabbit IgG, and was quantitated by densitometry. The GM2 contents of these sera were 20 to 100 times higher than those of sera from normal adults. By the method used, an increased GM2 level could be detected with samples of less than 0.1 ml of sera from hepatoma patients. The elevated levels of serum GM2 in hepatoma patients were suggested to be due to elevated GM2 levels in the liver lesions, because the GM2 contents of the liver of five patients with liver cancer, including three with hepatoma, were higher than those of normal liver tissues.