gebhart/patrepeval huggingface dataset:
Bipolar monolithic amplifiers for a gigabit optical repeater (1984)

Main amplifier, AGC amplifier, and preamplifier ICs have been designed and fabricated using an advanced silicon bipolar process to provide the required characteristics of repeater circuits for a gigabit optical fiber transmission system. The bipolar technology used involved a separation width of 0.3 /spl mu/m between the emitter and the base electrode. New circuit techniques were also used. The differential type main amplifier has a peaking function which can be varied widely by means of DC voltage supplied at the outside IC terminal. A bandwidth which can be varied to about three times the value for a nonpeaking amplifier is easily obtained. The gain and maximum 3-dB down bandwidth were 4 dB and 4 GHz, respectively. The main feature of the AGC amplifier is that the diodes are connected to the emitters of the differential transistor pair to improve the linearity. The maximum gain and 3-dB down bandwidth were 15 dB and 1.4 GHz, respectively, and a dynamic range of 25 dB was obtained. The preamplifier has a shunt-series feedback configuration. Furthermore, a gain and 3-dB down bandwidth of 22 dB and 2 GHz, respectively, were achieved with an optimum circuit design. The noise figure obtained was 3.5 dB.
Switching strategies in a class of packet switching networks (1983)

This paper investigates some methods for improving the performance of Single Stage Shuffle Exchange Networks (SENs) and Multistage Interconnection Networks (MINs). The three new switching strategies proposed use extra buffers to enhance performance. Approximate analysis and simulation results indicate significant improvement in performance for both SENs and MINs. An intuitive method for determining the applicability of the approximate analysis is discussed and some performance measures, which should be useful in evaluating the performance of networks are defined.
Synergistic Effect of MiR-146a Mimic and Cetuximab on Hepatocellular Carcinoma Cells (2014)

Previously, we found that the expression of microRNA-146a (miR-146a) was downregulated in hepatocellular carcinoma (HCC) formalin-fixed paraffin-embedded (FFPE) tissues compared to the adjacent noncancerous hepatic tissues. In the current study, we have explored the in vitro effect of miR-146a on the malignant phenotypes of HCC cells. MiR-146a mimic could suppress cell growth and increase cellular apoptosis in HCC cell lines HepG2, HepB3, and SNU449, as assessed by spectrophotometry, fluorimetry, and fluorescence microscopy, respectively. Furthermore, western blot showed that miR-146a mimic downregulated EGFR, ERK1/2, and stat5 signalings. These effects were less potent compared to that of a siRNA targeting EGFR, a known target gene of miR-146a. Moreover, miR-146a mimic could enhance the cell growth inhibition and apoptosis induction impact of various EGFR targeting agents. The most potent combination was miR-146a mimic with cetuximab, presenting a synergistic effect. In conclusion, miR-146a plays a vital role in the cell growth and apoptosis of HCC cells and inducing miR-146a level might be a critical targeted molecular therapy strategy for HCC.
Bose‐Einstein‐Kondensation in einem Gas von Natrium‐Atomen (1996)

Abstract In einer neuartigen Atomfalle konnten wir Bose‐Einstein‐Kondensation von Natrium‐Atomen beobachten. Hiermit ist es innerhalb von wenigen Monaten einer zweiten Gruppe gelungen, in einem unabhängigen Experiment dieses Phänomen nachzuweisen. Die wesentlich kürzeren Kühlzeiten und die stark erhöhte Zahl von kondensierten Atomen sind wichtige Voraussetzungen für zukünftige Experimente.
0.2 T magnetic field inhibits angiogenesis in chick embryo chorioallantoic membrane (2004)

Inhibition of angiogenesis is a major target in the fight against cancer and other diseases. Although the effects of static magnetic fields on cancer development and cell growth have been investigated, effects on angiogenesis have received no attention so far. In this study we report the effects on angiogenesis of exposure to 0.2 T static magnetic field. Angiogenesis was analyzed using the chick embryo chorioallantoic membrane assay. Exposure to 0.2 T static magnetic field was achieved by placing the eggs for 3 hr in the isocentre of the magnet of a sectorial magnetic resonance tomograph used in clinical practice. In sham exposed specimens treated with phosphate buffered saline (negative control), no significant vascular reaction was detectable; 3 hr exposure to 0.2 T static magnetic field did not affect the basal pattern of vascularization or chick embryo viability. Prostaglandin E1 and fetal calf serum elicited a strong angiogenic response in sham exposed eggs. This angiogenic response was significantly inhibited by 3 hr exposure to 0.2 T static magnetic field. These findings point to possible use of static magnetic field in inhibiting angiogenesis; this effect could be exploited for treatment of cancer and other diseases where excessive angiogenesis is involved.
Different DRB1*03:01‐DQB1*02:01 haplotypes confer different risk for celiac disease (2017)

Celiac disease is associated with the HLA-DR3-DQA1*05:01-DQB1*02:01 and DR4-DQA1*03:01-DQB1*03:02 haplotypes. In addition, there are currently over 40 non-HLA loci associated with celiac disease. This study extends previous analyses on different HLA haplotypes in celiac disease using next generation targeted sequencing. Included were 143 patients with celiac disease and 135 non-celiac disease controls investigated at median 9.8 years (1.4-18.3 years). PCR-based amplification of HLA and sequencing with Illumina MiSeq technology were used for extended sequencing of the HLA class II haplotypes HLA-DRB1, DRB3, DRB4, DRB5, DQA1 and DQB1, respectively. Odds ratios were computed marginally for every allele and haplotype as the ratio of allelic frequency in patients and controls as ratio of exposure rates (RR), when comparing a null reference with equal exposure rates in cases and controls. Among the extended HLA haplotypes, the strongest risk haplotype for celiac disease was shown for DRB3*01:01:02 in linkage with DQA1*05:01-DQB1*02:01 (RR = 6.34; P-value < .0001). In a subpopulation analysis, DRB3*01:01:02-DQA1*05:01-DQB1*02:01 remained the most significant in patients with Scandinavian ethnicity (RR = 4.63; P < .0001) whereas DRB1*07:01:01-DRB4*01:03:01-DQA1*02:01-DQB1*02:02:01 presented the highest risk of celiac disease among non-Scandinavians (RR = 7.94; P = .011). The data also revealed 2 distinct celiac disease risk DR3-DQA1*05:01-DQB*02:01 haplotypes distinguished by either the DRB3*01:01:02 or DRB3*02:02:01 alleles, indicating that different DRB1*03:01-DQB1*02:01 haplotypes confer different risk for celiac disease. The associated risk of celiac disease for DR3-DRB3*01:01:02-DQA1*05:01-DQB1*02:01 is predominant among patients of Scandinavian ethnicity.
Beyond Target–Decoy Competition: Stable Validation of Peptide and Protein Identifications in Mass Spectrometry-Based Discovery Proteomics (2020)

In bottom-up discovery proteomics, target-decoy competition (TDC) is the most popular method for false discovery rate (FDR) control. Despite unquestionable statistical foundations, this method has drawbacks, including its hitherto unknown intrinsic lack of stability vis-à-vis practical conditions of application. Although some consequences of this instability have already been empirically described, they may have been misinterpreted. This article provides evidence that TDC has become less reliable as the accuracy of modern mass spectrometers improved. We therefore propose to replace TDC by a totally different method to control the FDR at the spectrum, peptide, and protein levels, while benefiting from the theoretical guarantees of the Benjamini-Hochberg framework. As this method is simpler to use, faster to compute, and more stable than TDC, we argue that it is better adapted to the standardization and throughput constraints of current proteomic platforms.
Dynamic constraint-based rendering of contacts in haptics (2016)

Kinesthetic haptic applications employ force feedback on top of graphic and sound modalities to enable the human operator to interact with objects within a virtual world. The force feedback sensation, in particular, is created by a haptic device that displays the forces arising from this interaction. These forces must accurately emulate a real contact interaction, an objective which is commonly referred to as high-fidelity force feedback rendering. To achieve this, the current paper proposes a constrained-based rendering using a virtual tool that comes into unilateral contact with the virtual objects. Unlike common quasi-static or quasi-dynamic formulations in the haptics literature, a truly dynamic physical interaction between the virtual tool and the objects is modeled here. The paper develops analytical formulations for a canonical problem including colliding contact, sustained contact, slip and stick friction. Initial simulation and experimental evaluations show the potential of this method for handling complicated contact scenarios such as those encountered in haptic simulations of spinal or dental surgeries.
Design of Multi-Singing Karaoke System and its Application in Customer Finance-aided Service on Internet (2007)

Financial engineering nowadays is heavily depending on the real-time investment decision-support system while providing the suggestions to investors for rebalancing their portfolios. Because of the rapid growth of interactive technologies in Internet, on-line customer finance-aided service (CFAS) is playing an important role to help discussing, exchanging valuable information or enjoying entertainment each other simultaneously based on the platform of multi-singing karaoke system. Today's online singing software allows only one-microphone performance. Duo singers can only take turns and use the same microphone. Also, they cannot hear each other simultaneously. This is one big disadvantage of online multi-singing software, hence brings the problems to the quality of CFAS. Therefore, the main purpose of this study is to create a system that allows several singers to sing in different places simultaneously and hear the other singers' voices at the same time. This system catches and analyzes the singers' signals from remote computer sources through Media Server. Also by network broadcasting, this system transmits the signals from the inviter's end to the invitee's end, which is deeply improving the quality of CFAS
Surface coil for MR imaging of the skin (1987)

A strategy for the design of surface coils for the imaging of extended superficial planar anatomic structures including skin and subcutaneous fat is presented. The central concept is to create an array of closely spaced coplanar radiofrequency current filaments parallel to BO, the polarizing field, with opposite current directions in adjacent filaments. A specific coil design with four such filaments for imaging at 1.5 T is presented. It consists of two pairs of counterrotating current (CRC) coils. Phantom images as well as representative images of normal skin are shown.
Late-Stage Sequential C-H Functionalization of Thiazolo[5,4-f]quina-zolin-9(8H)-one: Synthesis of a Library of Potential Kinase Inhibitors (2016)

International audience
Biphase Cobalt–Manganese Oxide with High Capacity and Rate Performance for Aqueous Sodium‐Ion Electrochemical Energy Storage (2017)

Abstract Manganese‐based metal oxide electrode materials are of great importance in electrochemical energy storage for their favorable redox behavior, low cost, and environmental friendliness. However, their storage capacity and cycle life in aqueous Na‐ion electrolytes is not satisfactory. Herein, the development of a biphase cobalt–manganese oxide (CoMnO) nanostructured electrode material is reported, comprised of a layered MnO 2 ⋅H 2 O birnessite phase and a (Co 0.83 Mn 0.13 Va 0.04 ) tetra (Co 0.38 Mn 1.62 ) octa O 3.72 (Va: vacancy; tetra: tetrahedral sites; octa: octahedral sites) spinel phase, verified by neutron total scattering and pair distribution function analyses. The biphase CoMnO material demonstrates an excellent storage capacity toward Na‐ions in an aqueous electrolyte (121 mA h g −1 at a scan rate of 1 mV s −1 in the half‐cell and 81 mA h g −1 at a current density of 2 A g −1 after 5000 cycles in full‐cells), as well as high rate performance (57 mA h g −1 a rate of 360 C). Electrokinetic analysis and in situ X‐ray diffraction measurements further confirm that the synergistic interaction between the spinel and layered phases, as well as the vacancy of the tetrahedral sites of spinel phase, contribute to the improved capacity and rate performance of the CoMnO material by facilitating both diffusion‐limited redox and capacitive charge storage processes.
Chronic G q signaling in AgRP neurons does not cause obesity (2020)

Maintaining energy homeostasis requires coordinating physiology and behavior both on an acute timescale to adapt to rapid fluctuations in caloric intake and on a chronic timescale to regulate body composition. Hypothalamic agouti-related peptide (AgRP)-expressing neurons are acutely activated by caloric need, and this acute activation promotes increased food intake and decreased energy expenditure. On a longer timescale, AgRP neurons exhibit chronic hyperactivity under conditions of obesity and high dietary fat consumption, likely due to leptin resistance; however, the behavioral and metabolic effects of chronic AgRP neuronal hyperactivity remain unexplored. Here, we use chemogenetics to manipulate G<sub>q</sub> signaling in AgRP neurons in mice to explore the hypothesis that chronic activation of AgRP neurons promotes obesity. Inducing chronic G<sub>q</sub> signaling in AgRP neurons initially increased food intake and caused dramatic weight gain, in agreement with published data; however, food intake returned to baseline levels within 1 wk, and body weight returned to baseline levels within 60 d. Additionally, we found that, when mice had elevated body weight due to chronic G<sub>q</sub> signaling in AgRP neurons, energy expenditure was not altered but adiposity and lipid metabolism were both increased, even under caloric restriction. These findings reveal that the metabolic and behavioral effects of chronic G<sub>q</sub> signaling in AgRP neurons are distinct from the previously reported effects of acute G<sub>q</sub> signaling and also of leptin insensitivity.
Detection of people and animals using non-imaging sensors (2011)

Non-imaging sensors offer low power and long lasting solutions for perimeter, border crossing, and forward operating base protection. In this paper, we study the utility of acoustic, seismic, and ultrasonic transducers for detection and identification of people and animals. Various algorithms will be developed for them, which are computationally less intensive and amenable to implement on sensor network. We identify the physics-based phenomenology associated with the targets and the features selected for classification are based on the phenomenology. We fuse the results from various sensor modalities to achieve higher probability of correct classification.
Large-scale comparison of intron positions among animal, plant, and fungal genes (2002)

We purge large databases of animal, plant, and fungal intron-containing genes to a 20% similarity level and then identify the most similar animal-plant, animal-fungal, and plant-fungal protein pairs. We identify the introns in each BLAST 2.0 alignment and score matched intron positions and slid (near-matched, within six nucleotides) intron positions automatically. Overall we find that 10% of the animal introns match plant positions, and a further 7% are "slides." Fifteen percent of fungal introns match animal positions, and 13% match plant positions. Furthermore, the number of alignments with high numbers of matches deviates greatly from the Poisson expectation. The 30 animal-plant alignments with the highest matches (for which 44% of animal introns match plant positions) when aligned with fungal genes are also highly enriched for triple matches: 39% of the fungal introns match both animal and plant positions. This is strong evidence for ancestral introns predating the animal-plant-fungal divergence, and in complete opposition to any expectations based on random insertion. In examining the slid introns, we show that at least half are caused by imperfections in the alignments, and are most likely to be actual matches at common positions. Thus, our final estimates are that approximately equal 14% of animal introns match plant positions, and that approximately equal 17-18% of fungal introns match animal or plant positions, all of these being likely to be ancestral in the eukaryotes.
TGF-beta production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice (1997)

A severe, Th1-mediated experimental colitis with similarities to inflammatory bowel disease in humans can be induced by a single injection of 2,4,6-trinitrophenol (TNP)-substituted protein plus adjuvant in IL-2-/- mice. To determine the early events involved in the pathogenesis of IL-2-/-colitis, we compared the function of lamina propria (LP) T cells from IL-2-/- and IL-2+/+ mice subjected to disease-inducing (TNP-conjugated keyhole limpet hemocyanin [TNP-KLH]) and disease-inhibiting (anti-CD3) immunization protocols. We show that LP T cells in TNP-KLH-immunized IL-2-/- mice fail to produce TGF-beta early (day 2), whereas LP T cells in TNP-KLH-immunized IL-2+/+ mice exhibit an approximately eightfold rise in TGF-beta secretion. The critical importance of local TGF-beta production was further substantiated by the following findings. 1) LP T cells from TNP-KLH-immunized IL-2-/- mice administered anti-CD3 (i.p.) exhibit a significant rise in TGF-beta, production but fail to produce IFN-gamma, and such mice do not develop colitis. 2) TNP-KLH-immunized IL-2-/- mice administered anti-CD3 and coadministered anti-TGF-beta mAb again give rise to IFN-gamma-producing LP cells, and such mice develop colitis. 3) TNP-KLH-immunized IL-2+/+ mice administered anti-TGF-beta mAb exhibit pockets of mononuclear cell infiltrates in the LP. These results indicate that the disposition of IL-2-/- mice to develop chronic colonic inflammation is due to a Th1 cell response in the LP that is not appropriately counter-regulated by the production of the suppressor cytokine, TGF-beta.
Reduced Kidney Function Estimated by Cystatin C and Clinical Outcomes in Hypertensive Patients with Coronary Artery Disease: Association with Homocysteine and Other Cardiovascular Risk Factors (2010)

In hypertensive patients with CAD, serum cystatin C level was independently associated with the extent of CAD, homocysteine plasma level and traditional vascular risk factors. However, serum cystatin C concentration did not independently predict the combined end-point.
ELECTROLYTE-INDUCED SPIN-STATE TRANSITION OF IRON IN IRON(III) PHTHALOCYANINE (1984)

Abstract Magnetic susceptibility, magnetic circular dichroism(MCD), UV-visible absorption, and ESR spectroscopy have revealed that spin state of iron in 1,2,8,9,15,16,22,23-octadecyloxycarbonylphthalocyaninatoiron(III) dissolved in CH2Cl2 or CHCl3 changes from high-spin to low-spin state by the addition of ca. 10 equiv. of tetrabutylammoniumchloride (Bu4NCl) and/or -bromide(Bu4NBr), (electrolytes).
Shakespeare - práce - láska (2006)

Rozbor Shakespearových her s ohledem na postavy spojujici lasku
a praci: milenci, dohazovaci a zejmena postavy, ktere leci
lasku praci.
Markov random field models for unsupervised segmentation of textured color images (1995)

We present an unsupervised segmentation algorithm which uses Markov random field models for color textures. These models characterize a texture in terms of spatial interaction within each color plane and interaction between different color planes. The models are used by a segmentation algorithm based on agglomerative hierarchical clustering. At the heart of agglomerative clustering is a stepwise optimal merging process that at each iteration maximizes a global performance functional based on the conditional pseudolikelihood of the image. A test for stopping the clustering is applied based on rapid changes in the pseudolikelihood. We provide experimental results that illustrate the advantages of using color texture models and that demonstrate the performance of the segmentation algorithm on color images of natural scenes. Most of the processing during segmentation is local making the algorithm amenable to high performance parallel implementation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Mismatched filter for analogue TV-based passive bistatic radar (2011)

This study examines the problem of solving the range ambiguity in analogue TV (ATV)-based passive bistatic radar (PBR). When matched filter (MF) is applied to ATV-based PBR, a range ambiguity at 19.2 km will be produced because of the 64 µs line fly-back time of the ATV signal. The relatively short range and the severity of this ambiguity make application of this type of waveform much more likely to be limited. A novel mismatched filter (MMF) algorithm is developed for solving the problem of range ambiguity. In this new MMF algorithm, the MMF factor is acquired based on minimising the overall impact of the SNR loss (SL) compared to MF and the range sidelobes energy that the authors want to suppress. And a batch version with much computational saving is also introduced. Then the performance of this batch version is studied in detail. Finally, its effectiveness is demonstrated with the application to real data acquired with an experimental PBR system.
3-D OCT-based guinea pig eye model: Relating morphology & optics (2016)

Association for Research in Vision and Ophthalmology (ARVO), Seattle, Washington, United States, May 1 - May 5, 2016
[Bone morphogenetic protein (BMP) receptors and signal transduction]. (1999)

BMPs are multifunctional cytokines which regulate cellular proliferation, differentiation, apoptosis of various cell types, including osteoblasts and chondroblasts. These functions are related to various biological functions in vivo; e.g. formation of bone and cartilage, embryogenesis, and organogenesis. BMPs transduce signals through binding to type I and type II receptors with serine/threonine kinase activity. As for type I receptors, BMPs bind to BMP type IA receptor, BMP type IB receptor and activin type I receptor. As for type II receptors, BMPs bind to BMP type II receptor, activin type II receptor and activin type IIB receptor. In the receptor-ligand complexes, type II receptors phosphorylate type I receptors in the GS domain (domain rich in glycine, serine and threonine residues) to activate the latter. The activated type I receptors phosphorylate Smad family, which transduces the signals from cytoplasm into nuclei.
Toward energy-aware balancing of mobile graphics (2015)

In the area of computer graphics the design of hardware and software has primarily been driven by the need to achieve maximum performance. Energy efficiency was usually neglected, assuming that a stable always-on power source was available. However, the advent of the mobile era has brought into question these ideas and designs in computer graphics since mobile devices are both limited by their computational capabilities and their energy sources. Aligned to this emerging need in computer graphics for energy efficiency analysis we have setup a software framework to obtain power measurements from 3D scenes using off-the-shelf hardware that allows for sampling the energy consumption over the power rails of the CPU and GPU. Our experiments include geometric complexity, texture resolution and common CPU and GPU workloads. The goal of this work is to combine the knowledge obtained from these measurements into a prototype energy-aware balancer of processing resources. The balancer dynamically selects the rendering parameters and uses a simple framerate-based dynamic frequency scaling strategy. Our experimental results demonstrate that our power saving framework can achieve savings of approximately 40%.