gebhart/patrepeval huggingface dataset:
Organic Polymer Chemistry in the Context of Novel Processes (2019)

This article was written to shed light on a series of what some have stated are not so obvious connections that link polymer synthesis in supercritical CO2 to cancer treatment and vaccines, nonflammable polymer electrolytes for lithium ion batteries, and 3D printing. In telling this story, we also attempt to show the value of versatility in applying one's primary area of expertise to address pertinent questions in science and in society. In this Outlook, we attempted to identify key factors to enable a versatile and nimble research effort to take shape in an effort to influence diverse fields and have a tangible impact in the private sector through the translation of discoveries into the marketplace.
Business Process Execution Language for Web Services BPEL and BPEL4WS 2nd Edition (2006)

Web services provide the basic technical platform required for application interoperability. They do not, however, provide higher level control, such as which web services need to be invoked, which operations should be called and in what sequence. Nor do they provide ways to describe the semantics of interfaces, the workflows, or e-business processes. BPEL is the missing link to assemble and integrate web services into a real business process BPEL4WS standardizes process automation between web services. This applies both within the enterprise, where BPEL4WS is used to integrate previously isolated systems, and between enterprises, where BPEL4WS enables easier and more effective integration with business partners. In providing a standard descriptive structure BPEL4WS enables enterprises to define their business processes during the design phase. Wider business benefits can flow from this through business process optimization, reengineering, and the selection of most appropriate processes . Supported by major vendors - including BEA, Hewlett-Packard, IBM, Microsoft, Novell, Oracle, SAP, Sun, and others - BPEL4WS is becoming the accepted standard for business process management.This book provides detailed coverage of BPEL4WS, its syntax, and where, and how, it is used. It begins with an overview of web services, showing both the foundation of, and need for, BPEL. The web services orchestration stack is explained, including standards such as WS-Security, WS-Coordination, WS-Transaction, WS-Addressing, and others. The BPEL language itself is explained in detail, with Code snippets and complete examples illustrating both its syntax and typical construction. Having covered BPEL itself, the book then goes on to show BPEL is used in context. by providing an overview of major BPEL4WS servers. It covers the Oracle BPEL Process Manager and Microsoft BizTalk Server 2004 in detail, and shows how to write BPEL4WS solutions using these servers.
Environmental DNA monitoring: beware of the transition to more sensitive typing methodologies (2013)

Background DNA on surfaces and equipment utilised during forensic examination of exhibits poses a contamination risk. Many laboratories have established environmental DNA monitoring (EDM) programmes to generate awareness of locations, levels and origins of background DNA to identify contamination risk reduction opportunities. To evaluate the impact on contamination risk of introducing new DNA profiling systems we have analysed 134 EDM samples from surfaces within our forensic biology laboratory. The samples were profiled for our current system (Profiler Plus) and the new systems PowerPlex 21 and Yfiler. Many samples deemed clean using Profiler Plus yielded alleles using PowerPlex 21 and those with few alleles using Profiler Plus yielded many with PowerPlex 21. The detectability of alleles in multiple samples with negative quantification results using Quantifiler suggests that items able to be deemed free of detectable DNA by the newly introduced standard, AS 5483-2012, are not so when utilising DNA typing systems as sensitive as PowerPlex 21. Current cleaning procedures are shown to be less adequate when operating with PowerPlex 21. This study highlights the need for a range of issues pertaining to contamination risk to be addressed prior to the introduction of more sensitive profiling systems such as PowerPlex 21 into casework.
Repression of Wnt/β-catenin response elements by p63 (TP63) (2016)

Submitted: TP63 (p63), a member of the tumor suppressor TP53 (p53) gene family, is expressed in keratinocyte stem cells and well-differentiated squamous cell carcinomas to maintain cellular potential for growth and differentiation. Controversially, activation of the Wnt/β-catenin signaling by p63 (Patturajan M. et al., 2002, Cancer Cells) and inhibition of the target gene expression (Drewelus I. et al., 2010, Cell Cycle) have been reported. Upon p63 RNA-silencing in squamous cell carcinoma (SCC) lines, a few Wnt target gene expression substantially increased, while several target genes moderately decreased. Although ΔNp63α, the most abundant isoform of p63, appeared to interact with protein phosphatase PP2A, neither GSK-3β phosphorylation nor β-catenin nuclear localization was altered by the loss of p63. As reported earlier, ΔNp63α enhanced β-catenin-dependent luc gene expression from pGL3-OT having 3 artificial Wnt response elements (WREs). However, this activation was detectable only in HEK293 cells examined so far, and involved a p53 family-related sequence 5' to the WREs. In Wnt3-expressing SAOS-2 cells, ΔNp63α rather strongly inhibited transcription of pGL3-OT. Importantly, ΔNp63α repressed WREs isolated from the regulatory regions of MMP7. ΔNp63α-TCF4 association occurred in their soluble forms in the nucleus. Furthermore, p63 and TCF4 coexisted at a WRE of MMP7 on the chromatin, where β-catenin recruitment was attenuated. The combined results indicate that ΔNp63α serves as a repressor that regulates β-catenin-mediated gene expression.
An IL‐2 proaerolysin fusion toxin that selectively eliminates regulatory t cells to enhance antitumor immune response (2019)

Abstract Background Recent success with immune‐checkpoint inhibitors in some tumor types has highlighted the power of the immune system to control and eradicate human cancer cells. However, these therapies have demonstrated a limited activity in prostate cancer, which has a more immunosuppressive microenvironment that can be because of the presence of a variety of inhibitory cell types, such as myeloid‐derived suppressor cells, mesenchymal stem cells, and regulatory T cells (Tregs). One strategy to improve the efficacy of immune‐based therapies for prostate cancer is to selectively eliminate these immunosuppressive cells within the tumor microenvironment. Methods We developed and characterized a chimeric protein consisting of the cytokine IL‐2 fused to binding mutant of the highly toxic bacterial toxin proaerolysin (ie IL2‐R336A). Results The IL2‐R336A fusion protein selectively kills immunosuppressive Tregs that express the IL‐2 receptor while having little to no effect on cells negative for this target. IL2‐R336A depleted Tregs in both tumor bearing and nontumor bearing mice. Tumor bearing mice vaccinated with a GMCSF‐expressing CT‐26 GVAX vaccine had reduced tumor growth when given IL2‐R336A before vaccination. IL2‐R336A also enhanced immune response to a model hemagglutinin antigen (HA) in HA‐tolerized mice. Conclusion These results suggest that this IL2‐R336A toxin may be a useful in improving the therapeutic efficacy of antitumor vaccines by enhancing the immune response against target tumor antigens.
Smart Automatic Braking With Pneumatic Bumper (2018)

The aim is to design and develop a control system based on a smart controlled automatic bumper activation system called â€œSmart Braking With Active Pneumatic bumperâ€. This system consists of IR Transmitter and Receiver , control unit , pneumatic bumper and Braking unit .In which the IR sensor senses the obstacle .If there is any obstacle closer to vehicle ,the control unit gives signal to bumper and brake activation system , due to this the brake and actuation of bumper acts simultaneously . https://zenodo.org/deposit/1412324
Quality-of-life results of an EORTC phase III randomized trial of adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases of solid tumors. (2010)

9036 Background: This study aimed to evaluate the effects of adjuvant whole brain radiotherapy (WBR) compared to no further radiotherapy after local treatment of a limited number of brain metastases in patients with stable solid tumor. We present the Health Related Quality of Life (HRQOL) results. Methods: HRQOL (EORTC QOL-C30 and BN-20) was a secondary endpoint in the trial. Out of 359, 317 patients (88.3% compliance) had baseline HRQOL assessments. Compliance was a challenge in this population: at month 6 some 51% of patients completed a HRQOL measure and at year one 45.1%. Therefore the analysis focuses on only the first year post baseline. The primary HRQOL endpoint was global QoL; secondary HRQOL endpoints were Cognitive, Physical, Emotional, Role Functioning and Fatigue. Sensitivity analyses were planned and undertaken for all scales. Statistical significance required p≤0.05 and clinical relevance ≥10 pt difference. Results: Over the year studied, there were no significant differences in the primary endpoint, global HRQOL (p<0.12). Patients who underwent WBR had a lower physical functioning score (p = 0.0325) and a deteriorated cognitive function (p = 0.006). However, the difference in physical function was clinically relevant only at week 8 and that in cognitive function only at year one. No differences between the treatments were found for role (p>0.1) or emotional functioning (p>0.1) or fatigue (p = 0.077). Exploratory analysis of several other HRQOL scales suggested worse scores for the WBR group, but these differences were not clinically relevant (<10 pt) and were not sustained in time for most other scales. Explorations also suggested that the detriment was generally greater in patients who had WBRT after radio surgery than after surgical removal of the brain metastases. Conclusions: In summary, patients who underwent WBR suffered from worse HRQOL levels, but very few differences were observed or reached the level of clinical or statistical significance. No significant financial relationships to disclose.
Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids (2014)

During recent decades, the increasing use of opioids for chronic non-cancer pain has raised concerns regarding tolerance, addiction, and importantly cognitive dysfunction. Current research suggests that the somatotrophic axis could play an important role in cognitive function. Administration of growth hormone (GH) to GH-deficient humans and experimental animals has been shown to result in significant improvements in cognitive capacity. In this report, a patient with cognitive disabilities resulting from chronic treatment with opioids for neuropathic pain received recombinant human growth hormone (rhGH) replacement therapy. A 61-year-old man presented with severe cognitive dysfunction after long-term methadone treatment for intercostal neuralgia and was diagnosed with GH insufficiency by GH releasing hormone-arginine testing. The effect of rhGH replacement therapy on his cognitive capacity and quality of life was investigated. The hippocampal volume was measured using magnetic resonance imaging, and the ratios of the major metabolites were calculated using proton magnetic resonance spectroscopy. Cognitive testing revealed significant improvements in visuospatial cognitive function after rhGH. The hippocampal volume remained unchanged. In the right hippocampus, the N-acetylaspartate/creatine ratio (reflecting nerve cell function) was initially low but increased significantly during rhGH treatment, as did subjective cognitive, physical and emotional functioning. This case report indicates that rhGH replacement therapy could improve cognitive behaviour and well-being, as well as hippocampal metabolism and functioning in opioid-treated patients with chronic pain. The idea that GH could affect brain function and repair disabilities induced by long-term exposure to opioid analgesia is supported.
Rationalizing away Political Powerlessness: Equal Protection Analysis of Laws Classifying Gays and Lesbians (2007)

In November of 2000, Nebraska joined a growing number of states that have banned same sex marriage by passing a constitutional amendment prohibiting the recognition of same sex marriage, civil unions, and domestic partnerships. Unlike legislation and amendments in other states which either simply define marriage as a union between a man and a woman or refuse to recognize same sex marriage, the amendment to the Nebraska constitution is a broad prohibition on the recognition of any partnership rights for same sex couples. The United States Supreme Court has yet to establish whether or not gays and lesbians should be treated as a suspect or quasisuspect class under equal protection analysis. However, it is clear that as more state bans on gay marriage and civil unions are challenged, the Supreme Court may soon be forced to declare its stance on this issue. As evidenced by the decisions of lower courts, the final decision on this issue may center on the question of whether gays and lesbians constitute a politically powerless group. If, like some lower courts, the Supreme Court elects to measure the political power of gays and lesbians in a different manner than it has historically measured the political power of women and racial minorities, the Supreme Court will continue to apply rational basis review to legislation classifying by sexual orientation, rather than applying the heightened or strict scrutiny standards it has used with regard to gender and race, respectively.
Reactivity of the metal–metal bond in trimethylstannylpentacarbonylmanganese (1972)

Reaction between Me3SnH and Mn2(CO)10 affords Me3SnMn(CO)5(I), but in much poorer yield than other established routes. Unlike its trimethylsilyl analogue, (I) is unaffected by water, methanol, and also aqueous NaOH. Cleavage of the tin–manganese bond occurs quantitatively with 1,2-dibromoethane and HgCl2, and with RHgX(R = Me or Ph; X = Cl or Br) to give products dependent on R and X. With CF3COCl and HSiCl3, displacement of one methyl group from tin occurs yielding Me2ClSnMn(CO)5(II), whereas SnCl4 successively cleaves all three tin–carbon bonds. In the Raman spectrum of (II), ν(Sn–Mn) is at 194 cm–1, compared with 178 cm–1 for (I).
Thiocyanation, Halogenation, Dehalogenation, Transhalogenation, and Nitration of 2‐Substituted 4‐(2‐Furyl)thiazoles. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
GGTA-1 targeting efficiency with a xenograft transgene (2012)

The pig is considered to be the most suitable nonhuman source of organs for xenotransplantation.Advancements in transgenics has allowed for genetically modified (GM) swine to potentially fill the clinical need for viable human donor organs.The ablation of rejection barriers in addition to human transgenes, which combat multiple human immune barriers, is going to be required in order for porcine tissues to be compatible with human recipients.Current strategies for generating such GM pigs include the knockout of the porcine 1,3-Galactosyltransferase (GGTA-1) gene, along with the inclusion of randomly inserted human transgenes.Efficiencies in the production of pigs with multiple modifications, addition of transgenes, could be improved if each modification was located in a single locus.Gene targeting by homologous recombination was utilized to target the GGTA-1 locus.These studies demonstrated for the targeting vector used herein, single-stranded DNA and double-stranded DNA yielded similar targeting efficiencies.In addition, tDT inclusion within the vector or as a co-transfectant did not enrich gene targeting provided by the promoter trap strategy alone.The strategies evaluated within were able to achieve a targeting frequency of 13% with a targeting efficiency of 1.5 X 10^5 to 2.5 X 10^6.This is the first study to report the addition and expression of a human transgene, hCD55, in the porcine GGTA-1 locus.Subsequent offspring had prominent expression of hCD55 in all tissues examined.The data combined suggests that the GGTA-1 locus can be targeted at a high frequency and the GGTA-1 locus could be a safeharbor for transgenes.
Time-Frequency Analysis of Musical Instruments (2002)

This paper describes several approaches to analyzing the frequency, or pitch, content of the sounds produced by musical instruments. The classic method, using Fourier analysis, identifies fundamentals and overtones of individual notes. A second method, using spectrograms, analyzes the changes in fundamentals and overtones over time as several notes are played. Spectrograms produce a time-frequency description of a musical passage. A third method, using scalograms, produces far more detailed time-frequency descriptions within the region of the time-frequency plane typically occupied by musical sounds. Scalograms allow one to zoom in on selected regions of the time-frequency plane in a more flexible manner than is possible with spectrograms, and they have a natural interpretation in terms of a musical scale. All three of these techniques will be employed in analyzing music played on a piano, a flute, and a guitar. The two time-frequency methods, spectrograms and scalograms, will be shown to extend the classic Fourier approach, providing time-frequency portraits of the sounds produced by these instruments. Among other advantages, these time-frequency portraits seem to correlate well with our perceptions of the sounds produced by these instruments and of the differences between each instrument. There are many additional applications of time-frequency methods, such as compression of audio and resolution of closely spaced spectral lines in spectroscopy. Brief discussions of these additional applications are included in the paper.
Predictive Classification of Water Consumption Time Series Using Non-homogeneous Markov Models (2017)

The analysis of time series data issued from smart meters has been studied relatively extensively in the electricity domain. Meanwhile, analysis of medium resolution water consumption data collected via smart meters has become possible recently, and the research has tried to develop statistical and machine learning tools in order to respond to different requirements of the domain, e.g., better understanding of water consumption behaviors and prediction of consumption. In the present paper, we propose a new predictive approach based on Non-homogeneous Markov Models in order to learn the dynamics of water consumption behavior and be able to predict future consumption behaviors with a daily time-step based on different relevant exogenous covariates. The data used for this purpose are categorical time series, where each series corresponds to a smart meter and each category corresponds to a specific daily consumption behavior. The experiments are performed on a real data set provided by a water utility in France. Prediction results obtained with the proposed model are compared to those provided by two models, namely, the state independent model and homogeneous Markov model. This predictive classification can be helpful for water utilities in order to better manage the water resources and respond to consumer requirements.
Studies of tertiary amine oxides. Part 8. Rearrangement of N-(2,4-dinitrophenyl)-piperidines and -morpholine N-oxides in aprotic solvents (1987)

The N-oxides of N-(2,4-dinitrophenyl)-piperidines and -morpholine undergo thermal rearrangement to the substituted hydroxylamines. The kinetics of the rearrangement were studied in aprotic solvents at four or five temperatures. Steric and polar factors have great influence on the rate of rearrangement. The kinetic results together with cross-over experiments are in full agreement with an intramolecular cyclic mechanism (SNi).
Nitric Oxide Production by Macrophages Stimulated with Coccidia Sporozoites, Lipopolysaccharide, or Interferon-γ, and Its Dynamic Changes in SC and TK Strains of Chickens Infected with Eimeria tenella (2004)

Nitric oxide (NO) is an important mediator of innate and acquired immunities. In the studies reported here, we quantified NO produced in vitro by chicken leukocytes and macrophages and in vivo during the course of experimental infection with Eimeria, the causative agent of avian coccidiosis, and identified macrophages as the primary source of inducible NO. Eimeria tenella-infected chickens produced higher levels of NO compared with noninfected controls. In Eimeria-infected animals, SC chickens produced greater amounts of NO compared with infected TK chickens, particularly in the intestinal cecum, the region of the intestine infected by E. tenella. Macrophages that were isolated from normal spleen were a major source of NO induced by interferon (IFN)-gamma, lipopolysaccharide (LPS), and E. tenella sporozoites. Macrophage cell line MQ-NCSU produced high levels of NO in response to Escherichia coli or Salmonella typhi LPS, whereas the HD-11 macrophage cell line was more responsive to IFN-gamma. These findings are discussed in the context of the genetic differences in SC and TK chickens that may contribute to their divergent disease phenotypes.
Analyses thermique et calorimétrique différentielles (1992)

1 Généralités 1.1 Principes 1.2 Nomenclature : ATD, ACD, calorimétrie 1.3 Exploitation des thermogrammes 2 Saisie et traitement de données thermodynamiques 2.1 Étalonnage de la tête de mesure 2.2 Correction de ligne de base 2.3 Mesures d'enthalpie 2.31 Mesure de capacités
Interactions between Triazoles and Amphotericin B in Treatment of Disseminated Murine Infection by Fusarium oxysporum (2009)

We have evaluated and compared the efficacies of high doses of amphotericin B (AMB; 3 mg/kg of body weight/day), voriconazole (60 mg/kg), and posaconazole (PSC; 100 mg/kg) alone and combined in a murine model of disseminated infection by Fusarium oxysporum. The combination of AMB with PSC showed the best results, prolonging the survival of mice and reducing their organ fungal loads. This combination might constitute a therapeutic option for those infections where monotherapies fail.
Transillumination and reflectance probes forin vivonear-IR imaging of dental caries (2014)

Previous studies have demonstrated the utility of near infrared (NIR) imaging for caries detection employing transillumination and reflectance imaging geometries. Three intra-oral NIR imaging probes were fabricated for the acquisition of <i>in vivo,</i> real time videos using a high definition InGaAs SWIR camera and near-IR broadband light sources. Two transillumination probes provide occlusal and interproximal images using 1300-nm light where water absorption is low and enamel manifests the highest transparency. A third reflectance probe utilizes cross polarization and operates at >1500-nm, where water absorption is higher which reduces the reflectivity of sound tissues, significantly increasing lesion contrast. These probes are being used in an ongoing clinical study to assess the diagnostic performance of NIR imaging for the detection of caries lesions in teeth scheduled for extraction for orthodontic reasons.
Complexes of Starch with Dioic Acids (1995)

Abstract Attempts are presented for the preparation of complexes of starch with a series of dioic acids (oxalic, malonic, succinic, glutaric and adipic). The complexes are isolated and characterized by potentiometric titration, powder X‐ray diffraction, characteristics of gelation and differential scanning calorimetry. These complexes contain dioic acids on the level of 1 −3 g per 1g of starch. Oxalic acid forms a surface complex with crosslinking involving both its carboxylic groups. Malonic acid forms surface complex with involvement of only one of its carboxylic groups and all three succinic, glutaric and adipic acids form inclusion complexes.