gebhart/patrepeval huggingface dataset:
Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells (2007)

Endogenous damage-associated molecular pattern (DAMP) molecules are released from cells during traumatic injury, allowing them to interact with pattern recognition receptors such as the toll-like receptors (TLRs) on other cells and subsequently, to stimulate inflammatory signaling. TLR4, in particular, plays a key role in systemic and remote organ responses to hemorrhagic shock (HS) and peripheral tissue injury in the form of bilateral femur fracture. TLR4 chimeric mice were generated to investigate the cell lineage in which functional TLR4 is needed to initiate the injury response to trauma. Chimeric mice were generated by adoptive bone marrow (BM) transfer, whereby donor marrow was given to an irradiated host using reciprocal combinations of TLR4 wild-type (WT; C3H/HeOuJ) and TLR4 mutant (Mu; C3H/HeJ) mice. After a period of engraftment, chimeric mice were then subjected to HS or bilateral femur fracture. Control groups, including TLR4-WT mice receiving WT BM and TLR4-Mu mice receiving Mu BM, responded to injury in a similar pattern to unaltered HeOuJ and HeJ mice, and protection was afforded to those mice lacking functional TLR4. In contrast, TLR4-WT mice receiving Mu BM and TLR4-Mu mice receiving WT BM demonstrated intermediate inflammatory and cellular damage profiles. These data demonstrate that functional TLR4 is required in BM-derived cells and parenchymal cells for an optimal inflammatory response to trauma.
Using Scattering to Identify Bacterial Pathogens (2011)

New advances in elastic light scattering technology allow for faster and more accurate identification of bacteria. By using globally networked libraries of unique scattering patterns produced by bacterial colonies, researchers have developed an efficient method of identifying pathogens that has potential applications in food and water safety, health care and biodefense.
Psychosocial Correlates of Job Strain in a Sample of Working Women (1997)

The canonical correlation analysis results provide empirical support for the job strain construct. The most important finding is that health-damaging psychosocial factors like job strain, depression, hostility, anxiety, and social isolation tend to cluster in certain individuals.
Abstract A76: Anti IL-1b as a cancer immunotherapy (2020)

Abstract Inflammation in cancer can both suppress tumor growth and promote tumorigenesis. In the tumor microenvironment (TME), inflammation characterized by inflammatory cells and other mediators including cytokines affects tumor development and progression and can have an impact on response to therapy. The inflammatory cytokine IL-1b is upregulated in several conditions including rheumatoid arthritis, chronic obstructive pulmonary disease, inflammatory bowel disease, as well as in different cancers including breast, gastric, pancreatic, and lung cancers. IL-1b contributes to the generation and accumulation of myeloid-derived suppressor cells (MDSCs). In the tumor microenvironment, MDSCs consist of a mixture of immature macrophages, immature dendritic cells and neutrophils, which can suppress the function of antitumor T cells. In addition, IL-1b is produced via activation of the inflammasome, which has been shown to promote the infiltration of MDSCs and tumor-associated macrophages (TAMs) into the TME. Downstream of IL-1b production are other inflammatory cytokines such as IL-6, IL-8, and IL-17, which can also suppress the immune system. Recently published data show that blocking IL-1b in patients without cancer can lead to a decrease in fatal cancer and more specifically lung cancer incidences and fatalities (Ridker et al., 2017). While the study was not designed to study the anticancer effects of canakinumab (Ilaris), this finding has led to increased interest in understanding the role of IL-1b and IL-1b blockade in cancer development and progression. Emerging data aim to elucidate the role of IL-1b blockade on tumor growth and progression, as well as characterize changes to tumor-infiltrating lymphocyte (TIL) populations and their function after treatment with an anti-IL-1b antibody. Reference: Ridker PM et al. Effect of interleukin-1b inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomized, double-blind, placebo-controlled trial. Lancet 2017;390:1833-42. Citation Format: Reshma Singh, Rohan Diwanji, Pushpa Jayaraman, Derek Chiang, Catherine Sabatos-Peyton, Glenn Dranoff. Anti IL-1b as a cancer immunotherapy [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology and Immunotherapy; 2018 Nov 27-30; Miami Beach, FL. Philadelphia (PA): AACR; Cancer Immunol Res 2020;8(4 Suppl):Abstract nr A76.
Unraveling the Microbial Mechanisms Underlying the Psychobiotic Potential of a Bifidobacterium breve Strain (2021)

Genomic and metabolic features involving GHs and neuromodulatory metabolites may determine the antidepressant-like effect of B. breve CCFM1025. Psychobiotics' characterization in this manner may provide guidelines for developing novel psychopharmacological agents in the future.
Heat conduction in one-dimensional lattices with on-site potential (2003)

The process of heat conduction in one-dimensional lattices with on-site potential is studied by means of numerical simulation. Using the discrete Frenkel-Kontorova, phi(4), and sinh-Gordon models we demonstrate that contrary to previously expressed opinions the sole anharmonicity of the on-site potential is insufficient to ensure the normal heat conductivity in these systems. The character of the heat conduction is determined by the spectrum of nonlinear excitations peculiar for every given model and therefore depends on the concrete potential shape and the temperature of the lattice. The reason is that the peculiarities of the nonlinear excitations and their interactions prescribe the energy scattering mechanism in each model. For sine-Gordon and phi(4) models, phonons are scattered at a dynamical lattice of topological solitons; for sinh-Gordon and for phi(4) in a different parameter regime the phonons are scattered at localized high-frequency breathers (in the case of phi(4) the scattering mechanism switches with the growth of the temperature).
New Production Logging Technique for Horizontal Wells (1988)

Summary A new technique for running production logs in horizontal wells has been developed. The logging tools attached to a rigid stinger are pumped down a service tubing until they reach the zone to be logged. This paper describes the new technique and the first two case histories, Lacq 91 (France) and Rospo Mare 6 (Italy).
Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation (2002)

Gastro-oesophageal reflux is a common clinical disorder associated with a variety of respiratory symptoms, including chronic cough and exacerbation of asthma. In this study, the potential role of acid-induced tachykinin release was examined in guinea pigs and rabbits, by examining the effects of the tachykinin NK1 and NK3 receptors antagonists (SR 140333 and SR 142801, respectively) (1-10 mg x kg(-1)) on plasma protein extravasation induced in airways by hydrochloric acid (HCl) infusion in the oesophagus. Guinea pigs were anaesthetised with urethane, while rabbits were subject to neuroleptoanalgesia with hypnorm. Airway vascular leakage was evaluated by measuring extravasation of Evans blue dye. All animals were pretreated with atropine (1 mg x kg(-1) i.p.), propranolol (1 mg x kg(-1) i.p.), phosphoramidon (2.5 mg x kg(-1) i.v.) and saline or tachykinin receptor antagonists (1-10 mg x kg(-1) i.p.). Infusion of 1 N HCl into the oesophagus led to a three- and five-fold increase in plasma extravasation in the main bronchi and trachea, respectively. This increase was largely prevented by the tachykinin NK1 and NK3 receptor antagonists SR 140333 and SR 142801 (1-10 mg x kg(-1)). These results suggest that protein extravasation in the airways, as induced by intraoesophageal HCl infusion, is mainly dependent on the release of tachykinins, and that both NK1 and NK3 tachykinin receptors are involved. The results suggest that HCl-induced sensory nerve stimulation may act in the periphery on intermediate neurons and/or ganglia where NK3 receptors have been shown to play an important role.
Defining writer's invariants to adapt the recognition task (1999)

Investigates the automatic reading of unconstrained omni-writer handwritten texts. This paper shows how to endow the reading system with adaptation faculties for each writer's handwriting. The adaptation principles are of major importance for making robust decisions when neither simple lexical nor syntactic rules can be used, e.g. for a free lexicon or for full text recognition. The first part of this paper defines the concept of writer's invariants. In the second part, we explain how the recognition system can be adapted to a particular handwriting by exploiting the graphical context defined by the writer's invariants. This adaptation is guaranteed, thanks to the writer's invariants, by activating interaction links over the whole text between the recognition procedures for word entities and those for letter entities.
Vitamin D Receptor Gene Polymorphisms and the Risk of Fractures in Older Women (1999)

The association between vitamin D receptor gene polypmorphisms and bone mineral density is controversial. The relationship between vitamin D receptor genotype and risk of fracture is uncertain. To determine whether vitamin D receptor polymorphisms were associated with the risk of hip, vertebral, and other (nonhip, nonvertebral) fractures in elderly women, we conducted a case-cohort study within a prospective study of 9704 community-dwelling women aged 65 years and older. Vitamin D receptor allele and genotype frequencies in women who experienced first incident hip (n = 181), vertebral (n = 127), and other (n = 223) fractures were compared with those of control women selected randomly from the cohort. Average length of follow-up was 6.5, 3.7, and 5.4 years for women in hip, vertebral, and other fracture analyses, respectively. Vitamin D receptor polymorphisms were determined by polymerase chain reaction amplification of genomic DNA using TaqI and ApaI restriction site endonuclease digestion. All nonvertebral fractures were confirmed by X-ray reports; hip fractures were validated by review of X-ray films. Vertebral fractures were defined by morphometry using lateral spine radiography at baseline and an average of 3.7 years later. Allele or genotype frequencies did not differ between fracture cases and their respective controls. Vitamin D receptor genotype (defined by TaqI, ApaI, or the combination of TaqI and ApaI) was not significantly associated with the risk of hip, vertebral, or other fractures. For example, compared with the referent group of women with TT genotype, those with Tt and tt genotypes had similar age- and weight-adjusted risks of fracture at the hip (hazard ratios 0.9, 95% confidence interval [CI] 0.6-1.3, and 0.8, 95% CI 0.5-1.2, respectively), spine (odds ratios 1.1, 95% CI 0.7-1.8, and 0.7, 95% CI 0.4-1.3, respectively), or other skeletal site (hazard ratios 1.0, 95% CI 0. 7-1.4, and 1.0, 95% CI 0.7-1.5, respectively). These findings were not altered in additional analyses including those adjusted for and stratified by age, ethnic ancestry, calcaneal bone density, dietary calcium intake, use of calcium supplements, use of vitamin D supplements, and oral estrogen use. We conclude that Vitamin D receptor polymorphisms defined by TaqI and ApaI are not associated with the risk of fracture in older women. Our results suggest that determination of these vitamin D receptor polymorphisms is not a clinically useful test for the prediction of fracture risk in elderly women.
Enhancing all-optical switching of magnetization by He ion irradiation (2022)

All-optical switching (AOS) of magnetization by a single femtosecond laser pulse in Co/Gd based synthetic ferrimagnets is the fastest magnetization switching process. On the other hand, He ion irradiation has become a promising tool for interface engineering of spintronic material platforms, giving rise to significant modification of magnetic properties. In this paper, we explore the use of He ion irradiation to enhance single pulse AOS of Co/Gd bilayer-based synthetic ferrimagnets. The intermixing of the constituent magnetic layers by He ion irradiation was both numerically simulated and experimentally verified. We theoretically modeled the effects of intermixing on AOS using the layered microscopic 3-temperature model and found that AOS is enhanced significantly by breaking the pristine Co/Gd interface through intermixing. Following this notion, we studied the threshold fluence of AOS as a function of He ion irradiation fluence. We found that the AOS threshold fluence can be reduced by almost 30%. Our study reveals the control of AOS by He ion irradiation, which opens up an industrially compatible approach for local AOS engineering.
Spontaneous hybridization of macrophages and Meth A sarcoma cells (2002)

We present evidence of hybridization between Meth A sarcoma cells and syngeneic as well as semigeneic peritoneal macrophages. The resultant hybrids are characterized by morphology, membrane markers, ploidy, chromosomal content and functional features. Briefly, after a few days of coculture, cells appeared with morphology intermediate between the 2 original cell types. Typical macrophage surface molecules appeared in the hybrids. Meth A cells were labeled with red fluorescence and macrophages with green fluorescence. After 4 days in vitro, hybrids with yellow fluorescence appeared. Macrophages from BALB.K mice (H-2 K(k)) were cocultivated with Meth A cells from BALB/c mice (H-2 K(d)). The semigeneic hybrids displayed both specificities, as demonstrated by flow cytometry. The hybrids appeared moderately phagocytic, less so than the macrophages and markedly more so than the essentially nonphagocytic Meth A cells. The hybrids had a mean number of 76 chromosomes, as opposed to 53 in the Meth A cells and 40 in the macrophages. The macrophage DNA index was set at 1; Meth A cells were found to have an index of 1.6 in G1 phase, and the hybrids had a 2.6 index. The hybrids grew more slowly in vitro than Meth A cells, but grew faster in vivo.
Experience with new retrieval forceps for foreign body removal in the vascular, urinary, and biliary systems. (1990)

A new type of foreign body retrieval forceps recently has become available. It consists of single- or multiple-tooth forceps mounted on a flexible stainless steel 0.038-inch shaft. The authors have successfully used this device in the vascular system (three cases), in the urinary tract (seven cases), and in the biliary system (two cases) without complications. Foreign bodies removed include a catheter fragment, angiographic guide wire, detachable balloon, stone retrieval basket, and various stents. All the procedures were performed quickly and without difficulty. For the authors, these forceps have become the first choice in many retrieval situations.
Upregulated lncRNA SNHG1 contributes to progression of non-small cell lung cancer through inhibition of miR-101-3p and activation of Wnt/β-catenin signaling pathway (2017)

Lung cancer is the most common and aggressive tumor in the world. Long non-coding RNA small nucleolar RNA host gene 1 (lncRNA SNHG1) play critical roles in the progression of cancers. However, the function and underlying mechanism remain unclear in lung cancer. In the current study, we found that expression of SNHG1 was up-regulated in non-small cell lung cancer (NSCLC) tissues and cell lines. NSCLC patients with high SNHG1 expression were significantly correlated with larger tumor size, advanced TNM stage, lymph node metastasis and poor overall survival than patients with low SNHG1 expression. Furthermore, function assays showed that SNHG1 inhibition suppressed NSCLC cell proliferation both in vitro and in vivo. We also found that miR-101-3p could act as a target of SNHG1 in NSCLC and the inhibition of NSCLC progression induced by SNHG1 knockdown required the activity of miR-101-3p. In addition, we identified that SOX9 acted as a target of miR-101-3p, and SOX9 played the oncogenic role in NSCLC by activating Wnt/β-catenin signaling pathway. Taken together, our study suggested that lncRNA SNHG1 could promote NSCLC progression via miR-101-3p and SOX9. The SNHG1/miR-101-3p/SOX9/Wnt/β-catenin axis regulatory network might provide a potential new therapeutic strategy for lung cancer treatment.
A Diffusion Scrubber for the Collection of Gaseous Nitric Acid (1987)

Abstract A diffusion denuder with a thin anion exchanger membrane tube as the collecting element and with a scrubber solution flowing in a narrow annular gap outside the membrane is described. The use of this device with a dilute sulfate-sulfamic acid solution as scrubber has been exploited for collecting nitric acid. The method is essentially free from interference due to NO2, and response characteristics are described for a continuous flow application. Direct UV detection, used to demonstrate response characteristics in the continuous monitoring mode, is not sufficiently sensitive for the measurement of low levels of ambient gaseous HNO3.
TEDAS: A Twitter-based Event Detection and Analysis System (2012)

Witnessing the emergence of Twitter, we propose a Twitter-based Event Detection and Analysis System (TEDAS), which helps to (1) detect new events, to (2) analyze the spatial and temporal pattern of an event, and to (3) identify importance of events. In this demonstration, we show the overall system architecture, explain in detail the implementation of the components that crawl, classify, and rank tweets and extract location from tweets, and present some interesting results of our system.
The Quantum Mechanics Canonically Associated to Free Probability I: Free Momentum and Associated Kinetic Energy (2022)

After a short review of the quantum mechanics canonically associated with a classical real valued random variable with all moments, we begin to study the quantum mechanics canonically associated to the standard semi-circle random variable [Formula: see text], characterized by the fact that its probability distribution is the semi-circle law [Formula: see text] on [Formula: see text]. We prove that, in the identification of [Formula: see text] with the [Formula: see text]-mode interacting Fock space [Formula: see text], defined by the orthogonal polynomial gradation of [Formula: see text], [Formula: see text] is mapped into position operator and its canonically associated momentum operator [Formula: see text] into [Formula: see text] times the [Formula: see text]-Hilbert transform [Formula: see text] on [Formula: see text]. In the first part of the present paper, after briefly describing the simpler case of the [Formula: see text]-harmonic oscillator, we find an explicit expression for the action, on the [Formula: see text]-orthogonal polynomials, of the semi-circle analogue of the translation group [Formula: see text] and of the semi-circle analogue of the free evolution [Formula: see text], respectively, in terms of Bessel functions of the first kind and of confluent hyper-geometric series. These results require the solution of the inverse normal order problem on the quantum algebra canonically associated to the classical semi-circle random variable and are derived in the second part of the present paper. Since the problem to determine, with purely analytic techniques, the explicit form of the action of [Formula: see text] and [Formula: see text] on the [Formula: see text]-orthogonal polynomials is difficult, the above mentioned results show the power of the combination of these techniques with those developed within the algebraic approach to the theory of orthogonal polynomials.
Business Process Full Compliance with Respect to a Set of Conditional\n Obligation in Polynomial Time (2020)

In this paper, we present a new methodology to evaluate whether a business\nprocess model is fully compliant with a regulatory framework composed of a set\nof conditional obligations. The methodology is based failure delta-constraints\nthat are evaluated on bottom-up aggregations of a tree-like representation of\nbusiness process models. While the generic problem of proving full compliance\nis in coNP-complete, we show that verifying full compliance can be done in\npolynomial time using our methodology, for an acyclic structured process model\ngiven a regulatory framework composed by a set of conditional obligations,\nwhose elements are restricted to be represented by propositional literals\n
Molecular Markers for Genetic Analysis of Phytopathogenic Fungi (1987)

Genetic studies of any organism require precise, easily scored characters or markers. In the past, naturally occurring markers were often insufficient and mutagenesis was used to generate auxotrophic, morphological, or drug­ resistant mutants. These techniques have been extensively exploited to devel­ op several Ascomycete fungi (Saccharomyces cerevisiae, Aspergillus nidu­ lans, and Neurospora crassa) as model systems for rigorous genetic analysis (42). Despite the early demonstration of the Mendelian inheritance of genes determining virulence, progress in understanding the genetics of phyto­ pathogenic fungi has lagged behind other eukaryotes due to the difficulties of manipulation and the lack of suitable markers. Recently molecular techniques have provided two classes of markers that will allow extensive analysis of phytopathogenic fungi. Isozymes have been extensively used in several plant and animal species and are beginning to be employed with phytopathogenic fungi (13). DNA restriction fragment length polymorphism (RFLP) analyses are extensively used in human genetics, and are becoming routine with some plants (5, 66, 98, 103), but are in their infancy for phytopathogenic fungi. Molecular markers have several advan­ tages over other types of markers: (a) numerous molecular markers can be identified; (b) most are codominant (i.e. heterozygotes can be distinguished from homozygotes), allowing the identification of all possible genotypes; (c) they do not usually have deleterious or strong epistatic effects, allowing many markers to be considered simultaneously; (d) genotypes of molecular loci can often be determined from any tissue; and (e) numerous alleles may exist for some markers. In addition, RFLP markers may act as starting points for
Visualization of Pain Severity Events Using Semantic Structures (2016)

Physicians are often required to make critical medical decisions that may be based on previous events in the patient's health history. However, these events may be very difficult to locate in the patient record due to the large volume of unstructured textual data in the patient's chart. Even when the chart is housed in an electronic health record (EHR) system, keyword search within the chart may produce many results that are not relevant or that may overlook related expressions and concepts entirely. In addition, some medical events, such as the occurrence of symptoms, are associated with important attributes such as location or severity, and require other elements such as the type of clinical note and its date and time in order to provide the proper context of the event. This paper describes a prototype system that performs ontology-based semantic search through clinical text to extract pain severity events, and then presents them in a visualization to monitor the progression of pain over time.