gebhart/patrepeval huggingface dataset:
Formulation of Glutaraldehyde Disinfectant for Alginate Impressions. (1999)

The effect of buffer agents incorporated in glutaraldehyde disinfectants on the surface quality of dental models was examined by the measurement of surface roughness, X-ray diffraction analysis and SEM observation. Seven experimental glutaraldehyde disinfectants were prepared using two buffer agents, potassium acetate alone or potassium acetate and sodium hydrogen carbonate in combination. Four kinds of sulfate--zinc, calcium, potassium and magnesium sulfate--were added to these disinfectants in order to accelerate the hydration of calcium sulfate hemihydrate. The impressions treated with the experimental disinfectants for 1 h produced stone surfaces which had significantly lower surface roughness values than those treated with the commercial disinfectants (p < 0.05). The X-ray diffraction analysis and SEM observation showed that these superior surfaces were produced as a result of significant reductions in the amount of residual calcium sulfate hemihydrate. Replacement of buffer agents in commercial glutaraldehyde disinfectants with chemicals such as those studied in the present study will improve the surface quality of dental stone.
Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph (1996)

The adhesion molecules integrin alpha 4 beta 7 and L-selectin have been hypothesized to help direct selective migration (homing) of lymphocytes to the gut and peripheral lymph nodes, respectively. An important prediction of current models is that lymphocytes selectively recirculating through an organ will preferentially express adhesion receptors for organ-specific endothelial ligands. To test this prediction, we directly examined the expression of cell adhesion molecules on lymphocytes recirculating through the gut, the periphery, and the lung. Integrin beta 7 was highly expressed on CD4+CD45R- "memory/effector" T cells recirculating through the gut (mesenteric efferent and lower thoracic duct lymph). In contrast, cells recirculating through the periphery (prescapular efferent lymph) and the lung (caudal mediastinal efferent lymph) had much less beta 7 expression. A similar pattern of organ-specific beta 7 expression was seen on B cells. Beta 7 expression corresponded with adhesion to the gut mucosal addressin, MAdCAM-1, in vitro. The peripheral lymph node homing receptor, L-selectin, was expressed at higher levels on CD4+CD45R- T cells from peripheral lymph than on cells from gut or lung lymph. These results provide additional strong support for alpha 4 beta 7 and L-selectin involvement in lymphocyte homing to the gut and to peripheral lymph nodes, respectively. Lymphocytes emigrating from the lung expressed low levels of both homing receptors and likely utilize molecules other than alpha 4 beta 7 and L-selectin for migration to the lung and associated lymphoid tissue.
Baseline vs. cross-sectional MRI of concussion: distinct brain patterns in white matter and cerebral blood flow (2020)

Neuroimaging has been used to describe the pathophysiology of sport-related concussion during early injury, with effects that may persist beyond medical clearance to return-to-play (RTP). However, studies are typically cross-sectional, comparing groups of concussed and uninjured athletes. It is important to determine whether these findings are consistent with longitudinal change at the individual level, relative to their own pre-injury baseline. A cohort of N = 123 university-level athletes were scanned with magnetic resonance imaging (MRI). Of this group, N = 12 acquired a concussion and were re-scanned at early symptomatic injury and at RTP. A sub-group of N = 44 uninjured athletes were also re-imaged, providing a normative reference group. Among concussed athletes, abnormalities were identified for white matter fractional anisotropy and mean diffusivity, along with grey matter cerebral blood flow, using both cross-sectional (CS) and longitudinal (LNG) approaches. The spatial patterns of abnormality for CS and LNG were distinct, with median fractional overlap below 0.10 and significant differences in the percentage of abnormal voxels. However, the analysis methods did not differ in the amount of change from symptomatic injury to RTP and in the direction of observed abnormalities. These results highlight the impact of using pre-injury baseline data when evaluating concussion-related brain abnormalities at the individual level.
The Metabolic Response to Brain Injury (1987)

Every year several million people sustain brain injury. The development of an optimal metabolic and nutritional support program for brain-injured patients relies on an understanding of the metabolic response and nutritional complications that occur with brain injury. Severely brain injured patients have increased serum and urine levels of norepinephrine, epinephrine, and cortisol. These patients also have increased oxygen consumption and urinary nitrogen excretion. This group has observed hypozincemia, hyperzincuria, increased serum C-reactive protein and copper concentrations, and hypoalbuminemia in nonsteroid-treated severely brain-injured patients. Experimental head injury produces interleukin-1 (IL-1) of brain origin. This cytokine mediates many of the aspects of the acute phase response, including all of the metabolic abnormalities reported by our group. IL-1, when administered intracerebroventricularly to experimental animals, appears to have enhanced biological activity compared to that administered systemically. Interleukin-1 activity has been found in significant amounts in the intraventricular fluid of head-injured patients. We suggest that IL-1 acts in concert with traditional stress hormones such as epinephrine, norepinephrine, and cortisol to produce the profound metabolic disturbances observed in the head-injured patient.
A design methodology using concurrent eigenstructure assignment (2002)

In the sense of eigenstructure (eigenvalues/eigenvectors) assignment, the effectiveness and disturbance suppressibility of a controller are mainly depend on the left eigenstructure (eigenvalues/left eigenvectors) of a system. However, the disturbance decouplability is governed by the right eigenstructure (eigenvalues/right eigenvectors) of the system. In this paper, in order to obtain a disturbance decouplable as well as effective and disturbance suppressible controller a concurrent assignment methodology of the left and right eigenstructure is proposed. The biorthogonality property between the left and right modal matrices of a system as well as the relations between the achievable right modal matrix and states selection matrices are used to develop the methodology. The proposed concurrent eigenstructure assignment methodology guarantees that the desired eigenvalues are achieved exactly and the desired left and right eigenvectors are assigned to the best possible (achievable) sets of eigenvectors in the least square sense, respectively. An L-1011 flight control application is presented to illustrate the usefulness of the proposed methodology.
A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced‐Fit Pocket Stabilized by a Cation–π Interaction (2014)

The benzoxazinone and dihydroquinoxalinone fragments were employed as novel acetyl lysine mimics in the development of CREBBP bromodomain ligands. While the benzoxazinone series showed low affinity for the CREBBP bromodomain, expansion of the dihydroquinoxalinone series resulted in the first potent inhibitors of a bromodomain outside the BET family. Structural and computational studies reveal that an internal hydrogen bond stabilizes the protein-bound conformation of the dihydroquinoxalinone series. The side chain of this series binds in an induced-fit pocket forming a cation-π interaction with R1173 of CREBBP. The most potent compound inhibits binding of CREBBP to chromatin in U2OS cells.
Patient Age and Vasospasm After Subarachnoid Hemorrhage (2010)

Age does not seem to be a significant predictor for cerebral vasospasm after subarachnoid hemorrhage.
Electrophilic additions to tetradehydrodianthracene (1995)

Abstract 5,12:6,11‐Di[1,2]benzenodibenzo[a,e]cyclooctene (tetrade‐hydrodianthracene, TDDA) ( 1 ) reacts with halogens to give transannular ( anti ) 4, 5 and ring‐opened ( syn ) products 6, 7 . The product ratio shows a remarkable solvent dependence. Solvents of medium polarity favor anti addition, whereas syn addition is observed both with increasing and decreasing polarity. For instance, chlorine in toluene adds 100% syn , in dichloroethane 56 % anti , and in trifluorethanol again 100% syn. It is concluded that, depending on solvent polarity, three different mechanisms for electrophilic addition are operative.
Multi-view relighting using a geometry-aware network (2019)

We propose the first learning-based algorithm that can relight images in a plausible and controllable manner given multiple views of an outdoor scene. In particular, we introduce a geometry-aware neural network that utilizes multiple geometry cues (normal maps, specular direction, etc.) and source and target shadow masks computed from a noisy proxy geometry obtained by multi-view stereo. Our model is a three-stage pipeline: two subnetworks refine the source and target shadow masks, and a third performs the final relighting. Furthermore, we introduce a novel representation for the shadow masks, which we call RGB shadow images. They reproject the colors from all views into the shadowed pixels and enable our network to cope with inacuraccies in the proxy and the non-locality of the shadow casting interactions. Acquiring large-scale multi-view relighting datasets for real scenes is challenging, so we train our network on photorealistic synthetic data. At train time, we also compute a noisy stereo-based geometric proxy, this time from the synthetic renderings. This allows us to bridge the gap between the real and synthetic domains. Our model generalizes well to real scenes. It can alter the illumination of drone footage, image-based renderings, textured mesh reconstructions, and even internet photo collections.
Shear stabilization of critical fluctuations in bulk polymer blends studied by small angle neutron scattering (1990)

The small angle neutron scattering (SANS) technique has been used to study the concentration fluctuations of binary polymer mixtures under shear. Two different polymer systems, deuterated polystyrene/poly(vinylmethylether) and deuterated polystyrene/polybutadiene, have been studied as a function of temperature and shear rate. Due to the small wavelength of the incident neutron radiation compared with light, the shear dependence of concentration fluctuations in the one-phase region and in the strong shear limit has been obtained from the q dependence of the scattering structure factor for the first time. From a detailed analysis of the scattering structure factor S(q) a crossover value of the wave number qs has been obtained as a function of temperature and shear rate. This crossover wave number represents the inverse of the lowest fluctuation mode which is not affected by shear. The temperature, viscosity, and shear rate dependence of this experimentally determined qs agree well with a simple rotatory diffusion model and also the dynamic mode–mode coupling analysis of Kawasaki and Ferrell. The apparent spinodal temperature as a function of shear rate is shown to be consistent with the prediction of Onuki.
A dimensionality reduction approach to modeling protein flexibility (2002)

Proteins are involved either directly or indirectly in all biological processes in living organisms. It is now widely accepted that conformational changes of proteins can critically affect their ability to bind other molecules and that any progress in modeling protein motion and flexibility will contribute to the understanding of key biological functions. However, modeling protein flexibility has proven a very difficult task. Experimental laboratory methods such as X-ray crystallography produce rather few structures, while computational methods such as Molecular Dynamics are too slow for routine use with large systems. A medium sized protein typically has a few thousands of degrees of freedom. This paper shows how to obtain a reduced basis representation of protein flexibility. We use the Principal Component Analysis method, a dimensionality reduction technique, to transform the original high dimensional representation of protein motion into a lower dimensional representation that captures the dominant modes of motions of the protein. Although there is inevitably some loss in accuracy, we show that we can obtain conformations that have been observed in laboratory experiments, starting from different initial conformations and working in a drastically reduced search space.
BaZrSi3O9:Eu2+: a cyan-emitting phosphor with high quantum efficiency for white light-emitting diodes (2011)

In this paper, a cyan-emitting phosphor BaZrSi3O9:Eu2+ was synthesized and evaluated as a candidate for white light emitting diodes (WLEDs). This phosphor shows strong and broad absorption in 380–420 nm region, and the emission intensity of the optimized BaZrSi3O9:Eu2+ was found to be 90% and 198% of that of the commercial BaMgAl10O17:Eu2+ (BAM:Eu2+) under excitation at 405 nm and 420 nm, respectively. Upon excitation at 405 nm, the quantum efficiency of the optimized BaZrSi3O9:Eu2+ is 83% of that of BAM:Eu2+. The performance of this phosphor was further tested to fabricate white LED lamps. By coating BaZrSi3O9:Eu2+ with a green-emitting (Ba,Sr)2SiO4:Eu2+ and a red-emitting CaAlSiN3:Eu2+ on a near-ultraviolet (405 nm) LED chip, driven by a 350 mA forward bias current, intense warm white light with a color rendering index of 90 has been produced.
CARBOXYLIC TERMINAL DETERMINATION IN SIMPLER PEPTIDES BY SELECTIVE REDUCTION OF CARBOXYLIC GROUP BY SODIUM DIHYDRO BIS‐(2‐METHOXYETHOXY) ALUMINATE (1973)

The terminal carboxylic group in acylamino acids and peptides is selectively reduced by sodium dihydro bis‐( 2‐methoxyethoxy ) aluminate to alcoholic group. On hydrolysing the reduced acylamino acids or peptides, the original carboxy terminal amino acid is liberated as amino alcohol which can be easily identified. The reaction of reduced N‐acylamino alcohol with carbonyl diimidazole yields an N‐acyl‐2‐oxazolidone derivative from which the N‐acyl group is easily removed producing 2‐oxazolidone. The possibility of selective cleavage of the terminal amino alcohol and its characterisation as 2‐oxazolidone derivative has been investigated.
Fractures: Finite-size Scaling and Multifractals (1992)

The distributions of contact area and void space in single fractures in granite rock have been determined experimentally by making metal casts of the void spaces between the fracture surfaces under normal loads. The resulting metal casts on 52 cm diameter core samples show a complex geometry for the flow paths through the fracture. This geometry is analyzed using finite-size scaling. The spanning probabilities and percolation probabilities of the metal casts are calculted as functions of observation scale. Under the highest stresses of 33 MPa and 85 MPa there is a significant size-dependence of the geometric flow properties for observation scales smaller than 2 mm. Based on this data, the macroscopic percolation properties of the extended fracture can be well represented by relatively small core samples, even under normal stresses larger than 33 MPa. The metal casts also have rich multifractal structure that changes with changing stress.
Estimating the Hydraulic Conductivity of Landfilled Municipal Solid Waste Using the Borehole Permeameter Test (2006)

This paper reports the in situ field saturated hydraulic conductivity of municipal solid waste at a landfill in Florida. The saturated hydraulic conductivity (Ks) was estimated at 23 locations using the borehole permeameter test, a method commonly used for determination of the Ks of unsaturated soil. The Ks of the landfilled waste was found to range from 5.4×10−6 to 6.1×10−5cm∕s. The Ks was found to be on the lower end of the range of Ks reported by previous studies. The hydraulic conductivity of the waste decreased with depth, the likely result of greater overburden pressures associated with deep locations of the landfill. Permeability values (kw) of the landfilled waste calculated based on Ks were compared with permeability values estimated using air as the fluid (air permeability, ka). Values of ka were found to be approximately three orders of magnitude greater than those of kw. The lower permeability of the waste to water was primarily attributed to entrapped gas. Other factors such as potential clogging of media and short-circuiting of air along the well may also have contributed to the differences in ka and kw.
An Unexpected Reaction of 3-Ethoxycyclohex-2-enone with 3-Oxo-1,2-pyrazolidinium ylides: Preparation of 9-aryl-xanthenediones (2016)

An unexpected result from the reaction of 3-ethoxycyclohex-2-enone with 3-oxo-1,2-pyrazolidinium ylide is described. This transformation catalyzed by TFA/H2O in the presence of DMSO, leading to 9-aryl-xanthenediones in good yields (75-94%). The structures of the prepared compounds were characterized thoroughly by IR, elemental analysis, MS, NMR together with X-ray crystallographic analysis. A possible mechanism of this unusual reaction process is proposed.
Modification of Nuclear Restriction In Vitro by Plasma From Tumor-Bearing Animals 2 (1975)

Putative regulatory macromolecules, which may be useful in diagnosis or tumor detection, were identified in the peripheral blood plasma of tumor-bearing animals. We monitored the components by measuring their ability to stimulate messenger RNA (mRNA) release from isolated nuclei in a cell-free system of rat liver nuclei in fortified homologous cytosol. This in vitro test system exhibited near-normal in vivo nuclear RNA restriction. When added to the assay at a protein concentration of 3.0 mg/ml, dialyzed plasma from rats or mice with chemically induced transplantable or primary tumors stimulated mRNA release from 87% to more than 300% over control plasma from normal rats. Plasma from partially hepatectomized rats stimulated only 26% over control plasma. The test system derived from rat liver seemed to permit the monitoring of plasma from other species. Available evidence, particularly relating to tumor-host-interaction, suggests, but does not prove, that regulatory components are released from the tumor cells to the circulation.
Laser ablation of urethral hair (1999)

No improvement was seen; therefore, laser ablation was employed. Both patients remain free of regrowth at greater than one year of follow-up.
A case study exploring associations between popular media attention of scientific research and scientific citations (2020)

The association between mention of scientific research in popular media (e.g., the mainstream media or social media platforms) and scientific impact (e.g., citations) has yet to be fully explored. The purpose of this study was to clarify this relationship, while accounting for some other factors that likely influence scientific impact (e.g., the reputations of the scientists conducting the research and academic journal in which the research was published). To accomplish this purpose, approximately 800 peer-reviewed articles describing original research were evaluated for scientific impact, popular media attention, and reputations of the scientists/authors and publication venue. A structural equation model was produced describing the relationship between non-scientific impact (popular media) and scientific impact (citations), while accounting for author/scientist and journal reputation. The resulting model revealed a strong association between the amount of popular media attention given to a scientific research project and corresponding publication and the number of times that publication is cited in peer-reviewed scientific literature. These results indicate that (1) peer-reviewed scientific publications receiving more attention in non-scientific media are more likely to be cited than scientific publications receiving less popular media attention, and (2) the non-scientific media is associated with the scientific agenda. These results may inform scientists who increasingly use popular media to inform the general public and scientists concerning their scientific work. These results might also inform administrators of higher education and research funding mechanisms, who base decisions partly on scientific impact.
Synthesis of hyperbranched polymers by self-addition free radical vinyl polymerization of photo functional styrene (2000)

The hyperbranched polystyrenes are prepared by the self-addition free radical vinyl polymerization of N,N-diethylaminodithiocarbamoylmethylstyrene (DTCS). DTCS monomers play an important role in this polymerization system as an inimer that is capable of initiating living radical polymerization of the vinyl group. The compact nature of the hyperbranched macromolecules is demonstrated by viscosity measurements compared to the linear analogues.
Interleukin‐6 (IL‐6) functions as an in vitro autocrine growth factor in renal cell carcinomas (1989)

Interleukin-6 (IL-6) was found to be a growth factor of renal cell carcinomas Furthermore, renal cell carcinomas freshly isolated from the patients expressed mRNA of IL-6 and secreted biologically active IL-6 under the culture conditions where the tumor cells could grow, but they did not produce IL-6 nor proliferate in the absence of fetal calf serum. The production of IL-6 by the tumor cells was also demonstrated by immunostaining of the IL-6-producing cells utilizing anti-IL-6 antiserum. Moreover, anti-IL-6 antiserum specifically inhibited the in vitro tumor growth. All data indicated that IL-6 functions as an in vitro autocrine growth factor of renal cell carcinomas.
C1-Continuous Terrain Reconstruction from Sparse Contours. (2003)

Contour lines from topographic maps are still the most common form of elevation data for the Earth&amp;apos;s surface and in the case of historical landscapes, they often are the only available source of information. In this paper we present a new contour interpolation method that solves this bivariate problem by considering univariate curve interpolation along the approximate gradient directions of the unknown surface. For a point between two contours the height value is computed with Hermite interpolation based on the shortest distances to the contours and height and derivative information at the contours. The surfaces generated are C except at terrain characteristics such as ridges and valleys which are reconstructed as sharp features. The method also faithfully reconstructs summits, pits, and saddles and is especially well-suited for sparse sets of contours. The approach allows for an efficient numerical implementation as we demonstrate with a number of examples.
Uncertainty in velocity measurement based on diode-laser absorption in nonuniform flows (2012)

This work investigates the error caused by nonuniformities along the line-of-sight in velocity measurement using tunable diode-laser absorption spectroscopy (TDLAS). Past work has demonstrated TDLAS as an attractive diagnostic technique for measuring velocity, which is inferred from the Doppler shift of two absorption features using two crossing laser beams. However, because TDLAS is line-of-sight in nature, the obtained velocity is a spatially averaged value along the probing laser beams. As a result, nonuniformities in the flow can cause uncertainty in the velocity measurement. Therefore, it is the goal of this work to quantify the uncertainty caused by various nonuniformities typically encountered in practice, including boundary layer effects, the divergence/convergence of the flow, and the methods used to fit the Doppler shift. Systematic analyses are performed to quantify the uncertainty under various conditions, and case studies are reported to illustrate the usefulness of such analysis in interpreting experimental data obtained from a scramjet facility. We expect this work to be valuable for the design and optimization of TDLAS-based velocimetry, and also for the quantitative interpretation of the measurements.