gebhart/patrepeval huggingface dataset:
Automated dry thawing of cryopreserved haematopoietic cells is not adversely influenced by cryostorage time, patient age or gender (2020)

Cell therapies are becoming increasingly widely used, and their production and cryopreservation should take place under tightly controlled GMP conditions, with minimal batch-to-batch variation. One potential source of variation is in the thawing of cryopreserved samples, typically carried out in water baths. This study looks at an alternative, dry thawing, to minimise variability in the thawing of a cryopreserved cell therapy, and compares the cellular outcome on thaw. Factors such as storage time, patient age, and gender are considered in terms of cryopreservation and thawing outcomes. Cryopreserved leukapheresis samples from 41 donors, frozen by the same protocol and stored for up to 17 years, have been thawed using automated, water-free equipment and by conventional wet thawing using a water bath. Post-thaw viability, assessed by both trypan blue and flow cytometry, showed no significant differences between the techniques. Similarly, there was no negative effect of the duration of frozen storage, donor age at sample collection or donor gender on post-thaw viability using either thawing method. The implication of these results is that the cryopreservation protocol chosen initially remains robust and appropriate for use with a wide range of donors. The positive response of the samples to water-free thawing offers potential benefits for clinical situations by removing the subjective element inherent in water bath thawing and eliminating possible contamination issues.
Dysexecutive Syndrome After Mild Cerebral Ischemia? (2003)

After mild ischemia, mice recover with mild neurological deficits and normal motor coordination. Stroke mice have no obvious deficits in spatial learning in the Morris water maze but display distinct deficits related to strategy switching and relearning.
Elektrochemotherapie als effektive palliative Behandlung bei lokoregionär-rezidiviertem Vulvakarzinom: klinischer Fallbericht (2014)

Fragestellung: 83-jährige Patientin mit rezidiviertem, exophytisch wachsenden, exulcerierten Vulvakarzinom (ED 03/2008). Z.n. Exzision und RTX. Aufgrund mehrmaliger vorangegangener Exzisionen und wiederholter Radiatio keine Operabilität gegeben.
Total Dose Radiation Response of NROM-Style SOI Non-Volatile Memory Elements (2008)

For the first time, NROM-style nonvolatile memory elements were fabricated in SOI and irradiated. Total dose characterizations of these transistors indicate that this new style of memory can be functional to at least 500 krad (SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ).
Optical and thermal filtering nanoporous materials for sub-ambient radiative cooling (2018)

Emitting heat to Space is a passive, dry, and solid-state cooling approach with potential applications in thermal management of buildings, solar cells, and vehicles. Emitting in the 8–13 μm atmospheric window while preventing heat from reaching the cold emitter is important to the performance. Here, we investigate the design of infrared-transparent thermally-insulating materials for radiative cooling at deep sub-ambient temperatures. Unlike surface-based designs that rely on selective emission, selective radiative heat transfer with Space is achieved via selective transmission through an insulating cover. We model the radiative and thermal transport characteristics of several nanoporous materials that are transparent in the 8–13 μm range. We also study the effects of physical morphology and material composition on the scattering and absorption properties of the insulating cover, and its radiative cooling performance. By tailoring the nanostructure and material composition, one can define regions for short-wavelength scattering and long-wavelength absorption, and in turn, block solar and atmospheric heat. The combination of low thermal conductivity and selectively high transparency in the atmospheric window enable high-performance radiative cooling down to 35 K below ambient temperature.
Grassmannian sparse representations (2015)

We present Grassmannian sparse representations (GSR), a sparse representation Grassmann learning framework for efficient classification. Sparse representation classification offers a powerful approach for recognition in a variety of contexts. However, a major drawback of sparse representation methods is their computational performance and memory utilization for high-dimensional data. A Grassmann manifold is a space that promotes smooth surfaces where points represent subspaces and the relationship between points is defined by the mapping of an orthogonal matrix. Grassmann manifolds are well suited for computer vision problems because they promote high between-class discrimination and within-class clustering, while offering computational advantages by mapping each subspace onto a single point. The GSR framework combines Grassmannian kernels and sparse representations, including regularized least squares and least angle regression, to improve high accuracy recognition while overcoming the drawbacks of performance and dependencies on high dimensional data distributions. The effectiveness of GSR is demonstrated on computationally intensive multiview action sequences, three-dimensional action sequences, and face recognition datasets.
Membrane device and process for mass exchange, separation, and filtration (2023)

A membrane device and processes for fabrication and for using are disclosed. The membrane device may include a number of porous metal membranes that provide a high membrane surface area per unit volume. The membrane device provides various operation modes that enhance throughput and selectivity for mass exchange, mass transfer, separation, and/or filtration applications between feed flow streams and permeate flow streams.
Richardson Extrapolation-Based Discretization Uncertainty Estimation for Computational Fluid Dynamics (2014)

This study investigates the accuracy of various Richardson extrapolation-based discretization error and uncertainty estimators for problems in computational fluid dynamics (CFD). Richardson extrapolation uses two solutions on systematically refined grids to estimate the exact solution to the partial differential equations (PDEs) and is accurate only in the asymptotic range (i.e., when the grids are sufficiently fine). The uncertainty estimators investigated are variations of the grid convergence index and include a globally averaged observed order of accuracy, the factor of safety method, the correction factor method, and least-squares methods. Several 2D and 3D applications to the Euler, Navier–Stokes, and Reynolds-Averaged Navier–Stokes (RANS) with exact solutions and a 2D turbulent flat plate with a numerical benchmark are used to evaluate the uncertainty estimators. Local solution quantities (e.g., density, velocity, and pressure) have much slower grid convergence on coarser meshes than global quantities, resulting in nonasymptotic solutions and inaccurate Richardson extrapolation error estimates; however, an uncertainty estimate may still be required. The uncertainty estimators are applied to local solution quantities to evaluate accuracy for all possible types of convergence rates. Extensions were added where necessary for treatment of cases where the local convergence rate is oscillatory or divergent. The conservativeness and effectivity of the discretization uncertainty estimators are used to assess the relative merits of the different approaches.
Association Between Oral Corticosteroid Bursts and Severe Adverse Events : A Nationwide Population-Based Cohort Study. (2020)

National Health Research Institutes, Ministry of Science and Technology of Taiwan, Chang Gung Medical Foundation, and Eunice Kennedy Shriver National Institute of Child Health and Human Development.
Models of Accommodation Deficiency in Presbyopia Patients (2020)

Structured Abstract Purpose We describe new phenomenological illumination-dependent static models of the accommodation deficiency for patients with presbyopia. Such models are suitable for vision restoration with adaptive-optics accommodating eyeglasses and contact lenses. Methods Data from fifteen participants over the age of 45 and diagnosed with presbyopia was collected. Participants were asked to wear a pair of mechanically-tunable eyeglasses and clearly identify the optotypes corresponding to the LogMAR 0.0 line on Early Treatment of Diabetic Retinopathy Study (ETDRS) charts, by suitably adjusting the optical powers of the lenses on these tunable eyeglasses for each measurement. Seven ETDRS charts, placed at distances from the patients varying from 4 m through 30 cm, were used under three chart illumination levels (75 lx, 500 lx and 800 lx). The optical power of the lenses in the patient-adjusted tunable eyeglasses was subsequently measured using a Shack-Hartman wavefront sensor for each chart, which provided the accommodation deficiency data of the participants. Results The measured accommodation deficiency data from 15 presbyopes was curve-fitted to a model for each patient. The calculated root-mean-square error values for the fitted models ranged between 0.09 D – 0.67 D over a 3.08D accommodation stimulus range. Conclusions The data shows that while accommodation deficiency in humans is a function of the stimulus, it is also strongly dependent on the object illumination and age of the patients. The models adequately describe the relation between static accommodation deficiency, accommodation stimulus and object illumination.
Production and Processing of a Spherical Polybutylene Terephthalate Powder for Laser Sintering (2019)

This work describes the production of a spherical polybutylene terephthalate (PBT) powder and its processing with selective laser sintering (SLS). The powder was produced via melt emulsification, a continuous extrusion-based process. PBT was melt blended with polyethylene glycol (PEG), creating an emulsion of spherical PBT droplets in a PEG matrix. Powder could be extracted after dissolving the PEG matrix phase in water. The extrusion settings were adjusted to optimize the size and yield of PBT particles. After classification, 79 vol. % of particles fell within a range of 10–100 µm. Owing to its spherical shape, the powder exhibited excellent flowability and packing properties. After powder production, the width of the thermal processing (sintering) window was reduced by 7.6 °C. Processing of the powder on a laser sintering machine was only possible with difficulties. The parts exhibited mechanical properties inferior to injection-molded specimens. The main reason lied in the PBT being prone to thermal degradation and hydrolysis during the powder production process. Melt emulsification in general is a process well suited to produce a large variety of SLS powders with exceptional flowability.
A liquid emulsion membrane process for the separation of amino acids (1990)

The method of using liquid emulsion membranes featuring the cation carrier D2EHPA [di-(2-ethylhexyl) phosphoric acid] for the separation of L-phenylalanine is examined. Results from experiments performed under various conditions are discussed and an optimal condition for separation is determined. The selectivity of the liquid emulsion membrane system is discussed. The effects of impurities such as sodium chloride, glucose, lactic acid, and L-tryptophan on the transport of L-phenylalanine are evaluated. It is shown that the liquid emulsion membrane system is a potential operation not only to separate L-phenylalanine but also concentrate it with great efficiency.
Study of Gain Aperture under High Pump Power for the Development of High-brightness Ultra-compact MOPA (2019)

Gain aperture (GA) effect can simultaneously clean and amplify a laser beam. Calculations and experiments show that cm-size GA under 600W pump power can amplify laser up to 50 mJ keeping excellent beam quality.
Starches (1999)

Cereals & Grains Association is a nonprofit organization dedicated to advancing the knowledge and understanding of cereal grain science through research leadership, education, superior technical service, and advocacy.
Towards accessible synchronous communication (2002)

We present two synchronous communication systems, a video-mediated communication system called PEBBLES, and accessible, text-based communication tools called JAMTalk. PEBBLES combines video-conferencing with simple robotics to link a child in the hospital with his/her regular school. JAMTalk tools provide accessible real-time communication tools for distance education. We suggest that results from PEBBLES and JAMTalk evaluations indicate that accessible electronic communication systems can provide unique advantages to students with disabilities.
Electron polarization and plasmon effects in anisotropic nanostructures (2013)

Properties of nanorods with the length 2 a and radius b (a&amp;gt;b), containing free carriers, in the external d.c. or a.c. electric field are analyzed theoretically. Static polarizability of nanorods depends on their orientation in the field and is determined by the ratio, the nanorod size in the field direction to the screening length of the material rs. When this ratio is very small or very large, the properties of nanorods are similar to those of a dielectric and metallic ellipsoid, respectively. For a≫b, polarization characteristics of nanorods are strongly anisotropic and can be metallic in one direction and dielectric in the other direction. For semiconductor nanorods suspended in a polar liquid, polarizability in different directions may have different signs. For a.c. field, conductivity of nanorods contains plasmon peaks with essentially different frequencies for longitudinal and transverse plasmons. With decreasing a and b, frequencies of both plasmons increase and their amplitudes dramatically decrease. Dynamics of conducting nanorods in external electric fields represents superposition of their angular alignment along the field direction and the drift motion in the field gradient, with the first process being faster. Thus, in non-uniform fields nanorods drift in the field gradient according to the signs and values of their longitudinal and transverse polarizations.
DABCO and DMAP—Why Are They Different in Organocatalysis? (2007)

What makes a good organocatalyst? DABCO (1,4-diazabicyclo[2.2.2]octane) is a thousandfold better nucleophile (k→) and at the same time a million times better leaving group (k←) than DMAP (4-(dimethylamino)pyridine). This apparent contradiction is resolved by consideration of the intrinsic reaction barriers. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701489_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A Technique for Obtaining Hypervelocity Impact Data by using the Relative Velocities of Two Projectiles (1961)

A facility has been developed and put into operation to determine the feasibility of obtaining hypervelocity impact data by using the relative velocities of two projectiles. The facility utilizes the technique of firing a target toward an oncoming high-velocity projectile so that the impact velocity is equal to the sum of the projectile velocity and the target velocity. A 37-millimeter powder gun is utilized to accelerate the targets, and a specially designed 22-caliber light-gas gun accelerates the impacting projectiles. The light-gas gun is operated by detonating an explosive charge which permits it to be synchronized with the firing of the 37-millimeter gun. Impact velocities as great as 21,850 ft/sec have been obtained during development of the facility. After the oncoming projectiles impact the targets fired from the 37-millimeter gun, these targets are recovered by allowing them to impact into Celotex and soft wooden blocks. The craters formed in the targets then can be observed and measured. The results of several preliminary firings of the facility are included in this report.
The effect of a corticosteroid cream and a barrier‐strengthening moisturizer in hand eczema. A double‐blind, randomized, prospective, parallel group clinical trial (2011)

Twice daily use of corticosteroids was not superior to once daily use in treating eczema. On the contrary, the clinical assessment showed a larger benefit from once daily treatment compared with twice daily, especially in the group of patients with a moderate eczema at inclusion.
Fuzzy behavior fusion for reactive control of an autonomous mobile robot: MARGE (2002)

A distributed heterogeneous network of fuzzy control agents has been developed for reactive behavior-based control of an autonomous mobile robot This methodology allows the authors' vehicle, MARGE, to perform realistic tasks in unstructured environments. Control actions for the robot are generated by a colony of independent agents that compete and cooperate to determine the emergent motion of the vehicle. Fuzzy rules are used to implement a diverse array of real-time functions within one simple development environment. The authors' multi-layer approach differs from other methods that perform the fuzzy inference mapping in one step. Real-time control without special hardware is possible by using a singleton centroid calculation and by breaking complex behaviors down into simple modules.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
I-Ag7 is subject to post-translational chaperoning by CLIP (2010)

Several MHC class II alleles linked with autoimmune diseases form unusually low-stability complexes with class II-associated invariant chain peptides (CLIP), leading us to hypothesize that this is an important feature contributing to autoimmune pathogenesis. We recently demonstrated a novel post-endoplasmic reticulum (ER) chaperoning role of the CLIP peptides for the murine class II allele I-E(d). In the current study, we tested the generality of this CLIP chaperone function using a series of invariant chain (Ii) mutants designed to have varying CLIP affinity for I-A(g7). In cells expressing these Ii CLIP mutants, I-A(g7) abundance, turnover and antigen presentation are all subject to regulation by CLIP affinity, similar to I-E(d). However, I-A(g7) undergoes much greater quantitative changes than observed for I-E(d). In addition, we find that Ii with a CLIP region optimized for I-A(g7) binding may be preferentially assembled with I-A(g7) even in the presence of higher levels of wild-type Ii. This finding indicates that, although other regions of Ii interact with class II, CLIP binding to the groove is likely to be a dominant event in assembly of nascent class II molecules with Ii in the ER.
The MECA Payload as an Exobiology Laboratory on the MSP 2001 Lander (1999)

The Environmental Compatibility Assessment (MECA) payload for Mars Surveyor Project 2001 (MSP 2001) is comprised of a multifunctional laboratory equipped to assess martian soil properties with wet chemistry, camera imagery, optical microscopy (potentially with UV fluorescence capability), atomic force microscopy (AFM; potentially with mineral-discrimination capabilities), electrometry, active & passive external materials-test panels, mineral hardness testing, and electrostatic and magnetic materials testing. Additionally, evaluation of soil chemical and physical properties as a function of depth down to -50 cm will be facilitated by the Lander/MECA robot arm on which the camera (RAC) and electrometer are mounted. MECA was designed as a NASA Human Exploration and Development of Space (HEDS) payload for determining the properties of martian soil that may be detrimental to human exploration. It is, however, well equipped to address exobiology questions in the following areas: (1)Geochemical clues to Aqueous Mineralogy and Oxidant formation; (2) Soil structures and microfabrics as indicators of water-volatiles migration; (3) Minerals and rocks as clues to ancient hydrology; (4) Grain textures as indicators of aqueous activity and weathering. Additional information is contained in the original.
Systemic recombinant human placental growth factor-2 administration improves myocardial perfusion and contractile function at rest and during stress (2013)

Aim: We evaluated whether systemic infusion of recombinant human placental growth factor (rhPlGF)-2 improves regional myocardial perfusion, regional and global left ventricular (LV) function in a porcine model of ischemic cardiomyopathy. Methods: Myocardial ischemia was induced using a flow limiting stent. After 4 weeks, pigs with confirmed ischemic myocardial dysfunction were randomized to receive rhPlGF-2 (PlGF, 15μg/kg/day, n=12) or PBS (CON, n=12) for 10 days. At 8 weeks, treatment effect was evaluated using hemodynamic parameters and magnetic resonance imaging analysis of cardiac function and myocardial blood flow (MBF) at rest and during stress. Results: Infusion of rhPlGF-2 increased PlGF serum levels 64-fold (833±361 vs 13±4pg/ml before treatment, P<0.0001) without side effects. After 8 weeks, rhPlGF-2 significantly enhanced regional MBF in the ischemic area compared to CON pigs, both at rest (0.83±0.32 vs 0.58±0.21ml/min/g) and during hyperemia (1.50±0.50 vs 1.02±0.46ml/min/g) (P<0.05 for both). In the remote region, MBF were comparable in PlGF and CON (figure A). As a result, regional contractile function improved at rest (37±15% vs 23±9%, P<0.05) and was sustained in response to graded dobutamine stress (figure B). Increased MBF translated into a greater improvement in global LV function as evidenced by higher LVEF (52±11% vs 41±9%), preload recruitable stroke work (76±24 vs 41±21mmHg) and by smaller end systolic volume index (50±20 vs 72±29ml/m2) (P<0.05 vs CON for all). PlGF improves regional myocardial perfusion Conclusions: Systemic rhPlGF-2 infusion is safe and significantly enhances regional myocardial perfusion and contractile function at rest and during stress with a prominent recovery of global cardiac function. PlGF-2 protein infusion may represent a promising therapeutic strategy in chronic ischemic cardiomyopathy.
On Calculating Heat Transfer and Pressure Drop of Supercritical-Pressure Coolants (2016)

Specific features of thermophysical properties of single-phase supercritical-pressure (SCP) coolants and typical ranges of their thermodynamic state that determine heat-transfer regularities are presented. A brief analysis of the existing concepts on SCP-coolants heat transfer under turbulent flow in tube is given. Typical features of normal and deteriorated heat-transfer regimes are described. The simple classification of deteriorated heat-transfer regimes at high heat loads that make it possible to distinguish the causes and appraise a degree of heat-transfer deterioration danger is proposed. The results from the studies of the hydraulic-resistance structure under the regimes of normal and deteriorated heat transfer are considered and the conditions, when a one-dimensional (1-D) (homogeneous) flow model can be used in hydraulic calculations, are revealed. Using sounding measurements data, the interrelation between heat-transfer deterioration and radical changes in the averaged turbulent flow structure due to fluid thermal acceleration and Archimedes forces effects is analyzed. The recommendations on calculating normal heat transfer with an account of refined standards on thermophysical properties of water and carbon dioxide are presented. The review and analysis of the existing criteria for forecasting heat-transfer deterioration and assessing the boundaries of the normal heat-transfer range are given, and the correlations for describing deteriorated heat transfer are presented.