gebhart/patrepeval huggingface dataset:
Mining closed relational graphs with connectivity constraints (2005)

Relational graphs are widely used in modeling large scale networks such as biological networks and social networks. In this kind of graph, connectivity becomes critical in identifying highly associated groups and clusters. In this paper, we investigate the issues of mining closed frequent graphs with connectivity constraints in massive relational graphs where each graph has around 10K nodes and 1M edges. We adopt the concept of edge connectivity and apply the results from graph theory, to speed up the mining process. Two approaches are developed to handle different mining requests: CloseCut, a pattern-growth approach, and splat, a pattern-reduction approach. We have applied these methods in biological datasets and found the discovered patterns interesting.
Molecular Pathways: microRNAs, Cancer Cells, and Microenvironment (2014)

One of the most unexpected discoveries in molecular oncology over the last decade is the interplay between abnormalities in protein-coding genes and short noncoding microRNAs (miRNA) that are causally involved in cancer initiation, progression, and dissemination. This phenomenon was initially defined in malignant cells; however, in recent years, more data have accumulated describing the active participation of miRNAs produced by microenvironment cells. As hormones, miRNAs can be released by a donor cell in various forms of vesicles or as "free" molecules secreted by active mechanisms. These miRNAs spread as signaling molecules that are uptaken either as exosomes or as "free" RNAs, by cells located in other parts of the organism. Here, we discuss the communication between cancer cells and the microenvironment through miRNAs. We further expand this in a more translational context and present miRNAs as predictors of treatment response, as crucial agents in targeted therapeutics, and as significant molecules to target.
Effects of Third Elements on the Surface and Volume Perpendicular Coercivity of Co-Cr Films (1998)

The effects of third additive elements on the surface and volume perpendicular magnetic coercivity of Co-Cr alloy films were studied. The difference of surface and volume coercivities between the coercivity thickness dependences in Co-Cr-Ta and Nb films is discussed. It is clearly shown that the Co-Cr-Nb film shows almost the same tendency in the thickness dependence of both surface and volume coercivity. It is concluded that Co-Cr-Nb films are superior to Co-Cr-Ta in term of magnetic coupling in the film thickness direction, exhibiting a high crystallinity and a high crystal orientation.
Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice (2022)

Abstract The pathology of aging impacts multiple organ systems including the kidney, skeletal, and cardiac muscle. Long-term treatment with the mitochondrial targeted peptide elamipretide has previously been shown to improve in vivo mitochondrial function in aged mice that is associated with increased fatigue resistance and treadmill performance, improved cardiovascular diastolic function, and glomerular architecture of the kidney. However, elamipretide is a short tetrameric peptide that is not orally bioavailable limiting its routes of administration. This study tested whether twice weekly intermittent injections of elamipretide could recapitulate the same functional improvements as continuous long-term infusion. We found that intermittent treatment with elamipretide for 8 months preserved endurance running in mice, skeletal muscle force production, and left ventricular mass but did not affect heart or kidney function as previously reported using continuous treatment.
Evaluation of Trace Elements in Pancreatic Cancer Patients in Iran (2013)

Background: Pancreatic cancer is a major worldwide health problem. Little is known about the etiology of pancreatic cancer, which is an important cause of cancer mortality in developed countries. This study evaluates the importance of amounts of trace elements in pancreatic cancer etiology and diagnostics.Methods: Atomic absorption spectrometry was used to estimate zinc, selenium, copper, cadmium and lead concentrations in 80 patients with pancreatic cancer admitted to various hospitals in Tehran Province over an 18-month period and in 100 control subjects.Results: There were significantly lower levels (P<0.001) of zinc in patients' sera (63.12±26.45 μg/dl) compared with controls (107.05±30.23 μg/dl). The mean concentration of cadmium in patients (3.10±1.05 μg/l) was higher than in healthy subjects (1.52±0.88 μg/l; P<0.0001). In addition, there were significant variations in bloodcadmium concentrations due to tobacco smoking in both groups (P<0.001). No significant differences in levels of selenium, copper and lead were observed between the two groups (P>0.05).Conclusion: In this study and by analyzing data from recent major reported series, we have found that cadmium is a plausible pancreatic carcinogen. This study also suggests a significant relationship between zinc metabolism and pancreatic cancer.
Changes in immune activation in the T Cell compartments of HIV HCV coinfected patients during PEG IFN RBV treatment (2012)

Chronic activation of CD8 T-cell compartment is critical during HCV-HIV-1 coinfection. The objective of this study was to evaluate the impact of pegylated-interferon (PEG-IFN) in combination with ribavirin (RBV) on immune activation in HCV-HIV-coinfected patients.

T cell phenotype (CD8+CD38+,CD8+DR+) was quantified using flow cytometry analysis,. Measurements were performed at day one of treatment (Baseline, BL), then at week (W)12,W24,W48 and W24 post-treatment. HVC viral load was measured using a PCR (COBAS TaqMan 48; Roche), exhibiting a limit of detection at12 IU/ml. Statistical analysis was performed with SPSS 17.0.

11 pts (64% of males; median age 47.4 [45.1-51]) with a median follow up for HCV infection of 14.7y [11.7; 19.1]) were evaluated. All were treated for HIV infection (PI- based regimen: 63.6%) with an HIV-VL < 40copies/ml. Median CD4 and CD8 T cells count at BL was 886/mm3 [671; 1008] and 825/mm3 [530; 1843], respectively. HCV genotype was 1 for 63.6%, 3 in 27.3% and 4 in one pt. HCV VL at BL was 5.9 [4.6; 6.7] (log UI/ml). Up to now, 2 pts stopped HCV treatment at W2 and W4, 9 pts have reached W24, and 5 of them are between W24 and W48. The results at W12 and W24 are presented in the table. We observed a significant decrease of the number of circulating total lymphocytes and CD4T cells in absolute value (p=0.008), but a significant increase in the percentage of CD4+ T-cells and a significant decrease in the percentage of CD8+ T cells at W24. HCV VL was negative for all of them.

These preliminary results show that the immune system hyperactivation driving by HCV disease can be reduced with a control of HCV replication. However, we observed a discrepancy in the evolution of CD8+CD38+ and CD8+DR+ expression at W12 which remains at W24.These results have to be confirmed with the next measurement performed at W48 and W24 post treatment.



Table 1
In vitroandin vivoglucuronidation of midazolam in humans (2009)

A more complete picture of MDZ metabolism and the enzymes involved has been elucidated. Direct N-glucuronidation of MDZ occurs in vivo. Pharmacokinetic modelling using Simcyp illustrates an increased role for UGT1A4 under CYP3A inhibited conditions.
Multidisciplinary Aerodynamics/Structure Dynamics High-Performance Simulation and Optimization (1999)

Multidisciplinary computation methods are developed at Dasa Military Aircraft. The paper gives an overview of the design problems related to aerodynamics/structure dynamics couplings in aircraft design. The development approach of the elements of a future multidisciplinary simulation and optimization system is sketched. Selected results from the development of these elements are discussed. They are steady and unsteady flow computation, structural computation and optimization, multidisciplinary and multiobjective optimization and finally the time-domain aeroelastic coupling in the transonic regime.
Neutronic study on conversion of SAFARI-1 to LEU silicide fuel (1995)

This paper marks the initial study into the technical and economic feasibility of converting the SAFARI-1 reactor in South Africa to LEU silicide fuel. Several MTR assembly geometries and LEU uranium densities have been studied and compared with MEU and HEU fuels. Two factors of primary importance for conversion of SAFARI-1 to LEU fuel are the economy of the fuel cycle and the performance of the incore and excore irradiation positions.
Quantitative Tumor Cell Content of Bone Marrow and Blood as a Predictor of Outcome in Stage IV Neuroblastoma: A Children’s Cancer Group Study (2000)

Immunocytologic quantification of neuroblastoma cells in bone marrow and blood at diagnosis and in bone marrow during induction chemotherapy provides prognostic information that can identify patients with very high-risk disease who should be considered for experimental therapy that might improve outcome.
Picosecond regenerative Yb:YAG thin disk amplifier at 200 kHz repetition rate and 62 W output power (2007)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text C. Stolzenburg and A. Giesen, "Picosecond regenerative Yb:YAG thin disk amplifier at 200 kHz repetition rate and 62 W output power," in Advanced Solid-State Photonics, OSA Technical Digest Series (CD) (Optica Publishing Group, 2007), paper MA6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Parallax-Based Spatial and Channel Attention for Stereo Image Super-Resolution (2019)

Stereo images can provide more extra information to enhance performance of super-resolution (SR) owing to two different visual angles. Due to the attention mechanism has been widely employed in various computer vision tasks and achieved excellent performance, the recent methods for stereo SR utilize attention mechanism to obtain stereo correspondence. However, their attention mechanisms are generally spatial since they treat channel-wise features equally, which result in ignoring a lot of valuable information contained in the channels. In this paper, we propose a parallax-based spatial and channel attention stereo SR network (PSCASSRnet) to combine the stereo correspondence with the SR task. Specifically, we present a parallax-based spatial and channel attention module (PSCAM) to take full advantage of spatial and channel-wise characteristics to obtain the stereo correspondence. The extensive experiments prove that our PSCAM can produce more appropriate attention map with all possible disparities between the stereo image pair to achieve better SR performance, and our PSCASSRnet outperforms other state-of-the-art methods in the aspects of visual quality and quantitive on the three mainstream public datasets named KITTI2012, KITTI2015 and Middlebury respectively.
The role of nitric oxide in the regional vasodilator effects of endothelin‐1 in the rat (1992)

1. The role of nitic oxide (NO) derived from L-arginine in the regional vasodilator effects of endothelin-1 has been investigated in anaesthetized, spontaneously hypertensive (SH) rats in which autonomic reflexes were abolished by ganglion blockade. The experimental design incorporated animals infused with phenylephrine to mimic the peripheral vasconstrictor effects of the NO biosynthesis inhibitors and a single dose per animal paradigm to obviate problems of tachyphylaxis to the vasodilator effects of endothelin-1. 2. Infusion of the inhibitor of NO synthase, N-monomethyl-L-arginine (L-NMMA) at a dose (5 mg kg-1 min-1) which maximally raised blood pressure did not influence either the fall in blood pressure or the vasodilator responses induced in the hindquarters and carotid vascular beds by endothelin-1 (1 nmol kg-1, i.v.) The duration (but not the initial magnitude) of the vasodepressor response to endothelin-1 was however significantly attenuated (by 49%) during infusion of the more potent inhibitor of NO synthase, NG-nitro-L-arginine methyl ester (L-NAME), 2 mg kg-1 min-1. 3. Increasing the dose of L-NAME to 10 and 25 mg kg-1min-1 significantly attenuated, but did not abolish, the falls in blood pressure and hindquarters vasodilator responses to acetylcholine, 1 microgram kg-1, and endothelin-1, 1 nmol kg-1 min-1. The effects were selective in that vasodepressor responses to the endothelium-independent vasodilator, sodium nitroprusside, 1-10 micrograms kg-1 min-1, were unaltered. The effects were selective in that vasodepressor responses to the endothelium-independent vasodilator, sodium nitroprusside, 1-l0mg kg min , were unaltered.4. The data indicate that NO generated de novo from L-arginine mediates a significant component of the vasodilator effect of endothelin-1 in the anaesthetized, ganglion-blocked SH rat. However, a major component of the vasodepressor effects of both endothelin-1 and acetylcholine may occur independently of this mechanism.
Locomotor Responses of the Striped Bass, Morone saxatilis, to Environmental Variables (1981)

Loren G. Hill, Gary D. Schnell, William J. Matthews, Locomotor Responses of the Striped Bass, Morone saxatilis, to Environmental Variables, The American Midland Naturalist, Vol. 105, No. 1 (Jan., 1981), pp. 139-148
X-ray diffraction &#x2014; New eyes on the process (2014)

X-ray Diffraction (XRD) analysis of cement process materials has grown beyond its roots in the laboratory to become an important tool for process control. Combined with its partners, XRF and CNA, these techniques can provide valuable process control information - essentially “new eyes” - to guide process control decisions. Important developments in the XRD analyzers have decreased analysis time from hours to minutes to provide quick results that enable timely process control decisions. XRD phase analysis can provide information to optimize combustion control, mix chemistry, cooler operation as well as additive mixtures in finish cement. The paper will provide an overview of all the XRF/XRD applications and then focus on the XRD process control opportunities.
Fine Grained Authorization Through Predicated Grants (2007)

Authorization in SQL is currently at the level of tables or columns. Many applications need a finer level of control. We propose a model for fine-grained authorization based on adding predicates to authorization grants. Our model supports predicated authorization to specific columns, cell-level authorization with nullification, authorization for function/procedure execution, and grants with grant option. Our model also incorporates other novel features, such as query defined user groups, and authorization groups, which are designed to simplify administration of authorizations. Our model is designed to be a strict generalization of the current SQL authorization mechanism.
ZnO hexagonal microboxes enclosed only by {0001} facets with epitaxial nanowalls (2006)

Hexagonal ZnO microboxes constructed of ZnO {0001} facets with vertical and horizontal single-crystalline nanowalls were synthesized on Si(001) via a self-assembled process by thermal chemical vapor deposition. High-resolution transmission electron microscopy images show that ZnO sheets with nanowalls on top can be assembled at 86° and 62° to each other by twinning and epitaxy, respectively. The room-temperature cathodoluminescence spectrum of the microboxes shows a strong and sharp ultraviolet emission as well as a negligible green emission. The vertical and horizontal nanowalls have potential to be applied as templates for growth of vertically and horizontally aligned nanowires for three-dimensional nanoelectronics.
Determination of Serum Cystatin C: Biological Variation and Reference Values (2001)

Human cystatin C is a low molecular weight protein which has been proposed as a better marker of glomerular filtration rate than creatinine. To be able to interpret results obtained in different patient populations it is necessary to define cystatin C reference values. We measured serum concentration of cystatin C in 1223 subjects using a particle-enhanced nephelometric assay. Subjects were aged 4 to 79 years and were selected among apparently healthy individuals who came to the Centre for Preventive Medicine in Vandoeuvre-Lès-Nancy, France. We observed a Gaussian distribution of cystatin C concentration in serum. We did not find any effect of age or gender in children, hormonal status in women (puberty, menopause, oral contraceptives or hormone replacement therapy) or alcohol intake. Cystatin C concentration was slightly lower in female than in male adults below the age of 60 years. Cystatin C levels significantly increased above the age of 60 in both males and females, probably due to physiological aging of renal function. No other significant differences were observed between males and females. Using multiple regression analysis, moderate correlations were observed between body mass index and cystatin C, and between smoking and cystatin C, but these were not biologically significant. According to the literature, only methylprednisolone and cyclosporin A increased and decreased cystatin C levels, respectively. The reference values for cystatin C obtained in a carefully selected population were 0.75+/-0.089 mg/l for children aged 4-19 years, 0.74+/-0.100 mg/l for males and 0.65+/-0.085 mg/l for females (aged 20-59 years), and 0.83+/-0.103 mg/l for older individuals (> or =60 years).
The K-562 Cell Model for Analysis of Neutrophil NADPH Oxidase Function (2007)

Polymorphonuclear neutrophils (PMN) have a remarkable capacity for generation of large amounts of reactive oxygen species in response to a variety of infectious or inflammatory stimuli, a process known as the respiratory burst that involves activation of a multicomponent NADPH oxidase. Given their short life span, PMN are not amenable to most molecular biology methods for studying activation of this oxidant-generating system. We have explored a variety of methods for introduction of components of the phagocytic oxidase (phox system) into the promyelocytic erythroleukemia cell line, K-562. Here, we describe a series of cloned K-562 cell lines that were retrovirally transduced for stable production of one or more essential components of the phagocytic oxidase (phox) complex. We outline methods for the use of these transfectable cells for investigating structure, function, and signaling requirements for assembly and activation of the phox system. These versatile lines can be used to examine effects of genetic polymorphisms or mutations in phox components associated with chronic granulomatous disease, to serve as a system for testing gene therapy vectors designed to correct the defective oxidase, to study cross-functioning with recently described phox component homologs, or to explore signaling components involved in regulation of the respiratory burst.
Study on Stretching Methods of Biaxially Stretched Co-polyester Film with Has Uniaxially Heat Shrinkage Properties (2010)

Heat shrinkable film made of stretched film is widely used for decorative labels by attaching on PET bottles with heat shrinkage by steam or dry heating. Trouble cancellation in the installation process of the PET bottle is necessary. The purpose of this study is development of uniaxially heat shrinkable co-polyester film that has strength both in the machine direction (MD) and transverse direction (TD). The film production was performed using sequential biaxial stretched process that combined roll stretching with TD stretching. Cast film was processed in the order of TD stretching-Anneal 1-MD stretching-Anneal 2.As a result, the heat shrinkable film that shrunk only in MD got high tensile strength both in MD and TD. The anneal 1 temperature over Tg (Glass transition temperature) of material resin was needed to obtain the heat shrinkable film shrunk in MD after TD stretching.
Rational approach to the clinical protocol design for drug combinations: a review. (2001)

Based on the median-effect equation of Chou and the combination index (CI) equation of Chou-Talalay, a computer software for automated dose-effect analysis has been developed. This method provides quantitation of synergism (CI < 1) and antagonism (CI > 1) at different dose and effect levels. Therefore, it allows the selection of the best pair (or triplet) of combination, optimal combination ratio, and the best schedule of treatment. These analyses has been shown to be useful for the clinical protocol design. (Chang et al. Cancer Res. 45: 2434-2439, 1985). The user-friendly computer program also gives dose-reduction index (DRI) which determines how many fold of dose-reduction is allowed for each drug in synergistic combinations. Dose reduction leads to reduced toxicity while maintaining the desired efficacy (Chou et al. Encyclopedia of Human Biology 2:675-683, 1997; Encyclopedia of Cancer 1:368-379, 1997). The Chou-Talalay method distincts from all other methods by the fact that it not only takes into account the "potency" but also the "shape" of dose-effect curves of each drug and their combinations (Chou & Hayball, CalcuSyn for Windows, Biosoft, Cambridge UK, 1996). This method has been applied in combination of anticancer agents, anti-HIV agents, purging leukemic cells for autologous bone marrow transplantation (Chang et al. Cancer Res. 47:119-122, 1987) and combination of immunosuppressants for organs transplants. Specific examples of the theoretical equations, the median-effect plot, the CI plot, the isobologram, and the polygonogram are illustrated.
L1 Interaction Domains of Papillomavirus L2 Necessary for Viral Genome Encapsidation (2001)

BPHE-1 cells, which harbor 50 to 200 viral episomes, encapsidate viral genome and generate infectious bovine papillomavirus type 1 (BPV1) upon coexpression of capsid proteins L1 and L2 of BPV1, but not coexpression of BPV1 L1 and human papillomavirus type 16 (HPV16) L2. BPV1 L2 bound in vitro via its C-terminal 85 residues to purified L1 capsomers, but not with intact L1 virus-like particles in vitro. However, when the efficiency of BPV1 L1 coimmunoprecipitation with a series of BPV1 L2 deletion mutants was examined in vivo, the results suggested that residues 129 to 246 and 384 to 460 contain independent L1 interaction domains. An L2 mutant lacking the C-terminal L1 interaction domain was impaired for encapsidation of the viral genome. Coexpression of BPV1 L1 and a chimeric L2 protein composed of HPV16 L2 residues 1 to 98 fused to BPV1 L2 residues 99 to 469 generated infectious virions. However, inefficient encapsidation was seen when L1 was coexpressed with either BPV1 L2 with residues 91 to 246 deleted or with BPV1 L2 with residues 1 to 225 replaced with HPV16 L2. Impaired genome encapsidation did not correlate closely with impairment of the L2 proteins either to localize to promyelocytic leukemia oncogenic domains (PODs) or to induce localization of L1 or E2 to PODs. We conclude that the L1-binding domain located near the C terminus of L2 may bind L1 prior to completion of capsid assembly, and that both L1-binding domains of L2 are required for efficient encapsidation of the viral genome.
Tilted short base Fabry-Perot interferometer with inverted resonances in feedback system of widely tunable linear laser (2010)

The method of spectral selection based on weak coupling between a tilted short Fabry-Perot interferometer and a semiconductor optical amplifier has been proposed. An unusual effect was discovered at a certain inclination. Narrowband spectral maxima are observed in the light backreflected from a tilted short base Fabry-Perot interferometer at natural resonances. To demonstrate possible use of this effect for creation of selective feedback in a laser, a semiconductor laser with wavelength tuning range of ±10 nm at central wavelength 1290 nm and coherence length 8 mm has been developed.
ChemInform Abstract: New Methods for the Anionic Polymerization of α‐Activated Olefins (1988)

Abstract Review: (16 refs.