gebhart/patrepeval huggingface dataset:
Ultrahigh Photoresponsive Device Based on ReS2/Graphene Heterostructure (2018)

Heterostructures that combine graphene and transition metal dichalcogenides, such as MoS<sub>2</sub> , MoTe<sub>2</sub> , and WS<sub>2</sub> , have attracted attention due to their high performances in optoelectronic devices compared to homogeneous systems. Here, a photodevice based on a hybrid van der Waals heterostructure of rhenium disulfide (ReS<sub>2</sub> ) and graphene is fabricated using the stacking method. The device presents a remarkable ultrahigh photoresponsivity of 7 × 10<sup>5</sup> A W<sup>-1</sup> and a detectivity of 1.9 × 10<sup>13</sup> Jones, along with a fast response time of less than 30 ms. Tremendous photocurrents are generated in the heterostructure due to the direct bandgap, high quantum efficiency, and strong light absorption by the multilayer ReS<sub>2</sub> and the high carrier mobility of graphene. The ReS<sub>2</sub> /graphene heterostructured device displays a high photocurrent under the applied gate voltages due to the photogating effect induced by the junction between graphene and ReS<sub>2</sub> . The ReS<sub>2</sub> /graphene heterostructure may find promising applications in future optoelectronic devices, providing a high sensitivity, flexibility, and transparency.
Control of hybrid tripole HVDC based on LCC and F-MMC (2014)

In order to overcome some inherent defects of the conventional tripole HVDC, a hybrid tripole HVDC structure is proposed, which replaces the thyristor converters of pole 3 with the modular multilevel converters (F-MMC) based on cascaded full bridge sub-modules (FBSM). To increase the transmission capacity, a special current modulation is adopted. In order to meet the demands of the reactive power (voltage) balance, the DC current balance and the sub-module capacitor voltage balance in the transition process, the corresponding control strategies are also proposed. The performance of the proposed hybrid tripole HVDC structure is evaluated through time-domain simulation studies in PSCAD/EMTDC. The results show that a satisfactory response of the system can be achieved with the proposed control strategies.
The Lymphoid System in Hepatitis C Virus Infection: Autoimmunity, Mixed Cryoglobulinemia, and Overt B-Cell Malignancy (2000)

Like other hepatotropic viruses, hepatitis C virus (HCV) shares the property of inducing hepatocellular damage, possibly through induction of immune mechanisms that lead to hepatocellular necrosis. After infection of hepatocytes, and possibly other cells, humoral and cellular responses occur aimed at prevention of virus dissemination and elimination of infected cells. The early activated mechanisms include production of nonspecific and specific antibodies that represent the first-line of defense against invading foreign pathogens. As a consequence, circulating immune complexes are promptly formed, and antigen uptake and processing by specialized cells are enhanced. A major fraction of circulating immunoglobulins (Igs) are part of the spectrum of the so-called natural antibodies, which include anti-idiotypic antibodies and molecules with rheumatoid factor (RF) activity. They mainly belong to the IgM class, are polyclonal, and have no intrinsic pathogenetic potential. In 20-30% of HCV-infected patients, RFs share characteristics of high affinity molecules, are monoclonal in nature, and result in the production of cold-precipitating immune complexes and mixed cryoglobulinemia. It has been shown that anti-idiotypic antibodies and polyclonal and monoclonal RF molecules have the same cross-reactive idiotype, called WA, suggesting that their production is highly restricted. This strongly indicates that they arise from stimulation with the same antigen, likely HCV. It has also been speculated that B-1 (CD5+) and B-2 (CD5-) B-cell subsets, which use a limited number of VH germline genes, underlie the production of low-affinity polyclonal and high-affinity monoclonal antibodies, respectively. The persistent production of monoclonal RF molecules implies the existence of a further mechanism capable of restricting the reactivity and reflects a distinct selection of a cell population that can be maintained throughout life because they are continuously exposed to antigen pressure. Either polyclonal or monoclonal profiles of B-cell expansion are demonstrable in the liver of most HCV-infected patients. The occurrence of B-cell clonal expansion is strictly related to intrahepatic production of RF molecules, and this suggests that liver is a microenvironment, other than lymphoid tissue, in which a germinal centerlike reaction is induced. The frequent detection of oligoclonal B-cell expansion may, indeed, represent a key pathobiologic feature that sustains nonmalignant B-cell lymphoproliferation. The preferential expansion of one clone would in turn lead to a monoclonal pattern that could favor stochastic oncogenic events. It can be postulated that HCV is the stimulus not only for the apparent benign lymphoproliferative process underlying a wide spectrum of clinical features, but also for the progression to frank lymphoid malignancy in a subgroup of patients. Current data indicate a higher prevalence of overt B-cell non-Hodgkin's lymphoma in HCV-infected patients, especially in some geographic areas.
Fagaronine, a novel antileukaemic alkaloid (1992)

Abstract A review is presented about fagaronine, a benzophenanthridine alkaloid responsible for antitumoural activity. Plant source, extraction, biosynthesis, medicinal properties, especially antileukaemic activity, are described.
Control of Radial Electric Field in Torus Plasma (1994)

The radial electric field is controlled by changing the direction of neutral beam from co to counter to plasma current in tokamak, while it is controlled by the 2nd harmonic ECH and NBI and pellet infection in heliotron/torsatron.
Pharmacogenomic Discovery to Function and Mechanism: Breast Cancer as a Case Study (2017)

Biomedical research is undergoing rapid change, with the development of a series of analytical omics techniques that are capable of generating Biomedical Big Data. These developments provide an unprecedented opportunity to gain novel insight into disease pathophysiology and mechanisms of drug action and response-but they also present significant challenges. Pharmacogenomics is a discipline within Clinical Pharmacology that has been at the forefront in defining, taking advantage of, and dealing with the opportunities and challenges of this aspect of the Post-Genome Project world. This overview will describe the evolution of germline pharmacogenomic research strategies as we have moved from an era of candidate genes to agnostic genome-wide association studies (GWAS) coupled with the functional and mechanistic pursuit of GWAS signals. Germline pharmacogenomic studies of breast cancer endocrine therapy will be used to illustrate research strategies that are being applied broadly to omics studies of drug response phenotypes.
INFOTIC. Infografías académicas y herramientas de visualización de datos científicos con herramientas TIC: formación docente, diseño de recursos multimedia y experiencias didácticas para la enseñanza semipresencial (2021)

El proyecto ha gravitado en torno al uso didactico de las infografias cientificas como una herramienta destinada a la ensenanza semipresencial y telematica, aportando nuevos recursos para estudiantes y docentes y permitiendo implementar dinamicas adaptadas a las nuevas tecnologias. En este sentido, una infografia se puede definir como un conjunto de ideas complejas representadas mediante palabras, imagenes, graficos, etc., que les confieren un aspecto visualmente atractivo. Las infografias conforman un hilo comunicativo de transmision de estas ideas gracias al uso de textos informativos, que refuerzan su caracter pedagogico, e imagenes ilustrativas para potenciar la claridad y el dinamismo del mensaje. La visualidad de los datos integrados en las infografias es la caracteristica mas destacable de estos recursos, haciendolas interesantes para su aplicacion en la ensenanza y divulgacion academica. En el marco de este proyecto, poseen una finalidad eminentemente didactica, ayudando a que temas complejos puedan ser entendidos por un publico no especializado.
Discovery of RSV-Induced BRD4 Protein Interactions Using Native Immunoprecipitation and Parallel Accumulation—Serial Fragmentation (PASEF) Mass Spectrometry (2021)

Respiratory Syncytial Virus (RSV) causes severe inflammation and airway pathology in children and the elderly by infecting the epithelial cells of the upper and lower respiratory tract. RSV replication is sensed by intracellular pattern recognition receptors upstream of the IRF and NF-κB transcription factors. These proteins coordinate an innate inflammatory response via Bromodomain-containing protein 4 (BRD4), a protein that functions as a scaffold for unknown transcriptional regulators. To better understand the pleiotropic regulatory function of BRD4, we examine the BRD4 interactome and identify how RSV infection dynamically alters it. To accomplish these goals, we leverage native immunoprecipitation and Parallel Accumulation-Serial Fragmentation (PASEF) mass spectrometry to examine BRD4 complexes isolated from human alveolar epithelial cells in the absence or presence of RSV infection. In addition, we explore the role of BRD4's acetyl-lysine binding bromodomains in mediating these interactions by using a highly selective competitive bromodomain inhibitor. We identify 101 proteins that are significantly enriched in the BRD4 complex and are responsive to both RSV-infection and BRD4 inhibition. These proteins are highly enriched in transcription factors and transcriptional coactivators. Among them, we identify members of the AP1 transcription factor complex, a complex important in innate signaling and cell stress responses. We independently confirm the BRD4/AP1 interaction in primary human small airway epithelial cells. We conclude that BRD4 recruits multiple transcription factors during RSV infection in a manner dependent on acetyl-lysine binding domain interactions. This data suggests that BRD4 recruits transcription factors to target its RNA processing complex to regulate gene expression in innate immunity and inflammation.
Prospective cohort study of mother‐to‐infant infection and clearance of hepatitis C in rural Egyptian villages (2009)

Although persistent transmission of hepatitis C virus (HCV) from infected mothers to their infants is reported in 4-8%, transient HCV perinatal infection also occurs. This prospective cohort study determined perinatal HCV infection- and early and late clearance-rates in 1,863 mother-infant pairs in rural Egyptian villages. This study found 15.7% and 10.9% of pregnant women had HCV antibodies (anti-HCV) and HCV-RNA, respectively. Among 329 infants born of these mothers, 33 (10.0%) tested positive for both anti-HCV and HCV-RNA 2 months following birth-29 (12.5%) having HCV-RNA positive mothers and 4 (with transient infections) having mothers with only anti-HCV. Fifteen remained HCV-RNA positive at one and/or 2 years (persistent infections), while 18 cleared both virus and antibody by 1 year (transient infections). Among the 15 persistent cases, 7 cleared their infections by 2 or 3 years. At 2- to 6- and at 10- to 12-month maternally acquired anti-HCV was observed in 80% and 5% of infants, respectively. Four perinatally infected and one transiently infected infant were confirmed to be infected by their mothers by the sequence similarity of their viruses. Viremia was 155-fold greater in mothers of infants with persistent than mothers of infants with transient infections. Maternal-infant transmission of HCV is more frequent than generally reported. However, both early and late clearance of infection frequently occurs and only 15 (4.6%) and 8 (2.4%) infants born of HCV-RNA positive mothers had detectable HCV-RNA at one and 2-3 years of age. Investigating how infants clear infection may provide important information about protective immunity to HCV.
Parasites et parasitoses des poissons (2014)

This richly-illustrated work offers a representative panorama of parasitic agents encountered in fish. Based on the new phylogenetic classification concepts, it emphasises the biological properties, epidemiology and clinical effects of groups of organisms in question, in the light of cognitive advances made possible by the new biology tools. It is intended for a wide audience, from the world of aquaculture to animal health and teaching as well as to researchers.
Desarrollo de un sistema informático que apoye el control del plan anual operativo de la Administración Nacional de Acueductos y Alcantarillados (2013)

Sistema que apoya el control de las metas y actividades que se realizan en cada unidad de la institucion, dando seguimiento de cada meta planteada a ejecutarse segun cronograma y detalle planteado para un ano, permitiendo en cualquier instante ver el cumplimiento de lo planificado, causas de atraso, historial de cumplimiento, unidades que no han presentado su plan anual operativo, unidades que no han alcanzado los porcentajes definidos, por persona encargada de la planificacion institucional, mantenimiento de usuarios del sistema segun perfil de acceso, mantenimiento de unidades organizativas y su presupuesto anual, mantenimiento de catalogos, reasignacion de tecnicos que dan seguimiento al plan anual operativo de las unidades
Electromagnetic modeling of composite wire and surface geometries (1977)

A moment method solution to the problem of radiation or scattering from geometries consisting of open or closed surfaces, wires, and wire/surface junctions is presented. The method is based on the sinusoidal reaction formulation. Several examples of input impedance calculations illustrate the versatility, accuracy, and computational efficiency of the method.
Mesospheric Metals for Guide Star Generation (1995)

Elemental Na has been the tracer of choice for the generation of high altitude (mesospheric) guide stars because of its relatively large natural abundance and large absorption cross section. Dye based systems using Na are currently under development for several large aperture telescopes. However, robust solid state laser technology to generate high power narrow linewidth light at 589 nm has progressed slowly. Here we consider both the tracer and the transmitter technology and show that using either the K D 1 line at 769 nm or the 372 nm line of Fe ( a 5 D- z 5 F°) for the tracer may provide robust solutions until solid state Na transmitter technology can be more fully developed. The comparable performance is primarily due to the fact that both lines can be generated with existing solid state materials (Alexandrite, Ti:Sapphire).
Time and sample efficient discovery of Markov blankets and direct causal relations (2003)

Data Mining with Bayesian Network learning has two important characteristics: under conditions learned edges between variables correspond to casual influences, and second, for every variable T in the network a special subset (Markov Blanket) identifiable by the network is the minimal variable set required to predict T. However, all known algorithms learning a complete BN do not scale up beyond a few hundred variables. On the other hand, all known sound algorithms learning a local region of the network require an exponential number of training instances to the size of the learned region.The contribution of this paper is two-fold. We introduce a novel local algorithm that returns all variables with direct edges to and from a target variable T as well as a local algorithm that returns the Markov Blanket of T. Both algorithms (i) are sound, (ii) can be run efficiently in datasets with thousands of variables, and (iii) significantly outperform in terms of approximating the true neighborhood previous state-of-the-art algorithms using only a fraction of the training size required by the existing methods. A fundamental difference between our approach and existing ones is that the required sample depends on the generating graph connectivity and not the size of the local region; this yields up to exponential savings in sample relative to previously known algorithms. The results presented here are promising not only for discovery of local causal structure, and variable selection for classification, but also for the induction of complete BNs.
Strategies to reduce heat-induced darkening for enhanced bleachability of mechanical pulps (2014)

Under mechanical pulping conditions, elevated temperature initiates reactions in the wood constituents resulting in the formation of coloured structures. In an attempt to reduce the formation of colour, a number of additives have been examined to assess their ability to inhibit heat-induced darkening of a Norway spruce (Picea abies) stone groundwood (SGW) pulp. SGW pulp was used as a model pulp with the purpose of imitating a thermomechanical pulp (TMP). The heat-treated SGW pulp, both with and without additives present, was subsequently bleached with 4.5% hydrogen peroxide at high pulp consistency and with varying alkali charges in order to examine the hydrogen peroxide bleachability of such pulps.Heat treatment at 170 degreesC resulted in a loss of brightness of about 4% ISO after heating for 60 seconds. The reduction in brightness could only partly be regained through high consistency hydrogen peroxide bleaching; the SGW pulp displayed a brightness of 83.7% ISO whereas the heat-treated SGW pulp reached a brightness of 80.4% ISO. Heat treatment with a low addition rate (1%) of alkaline hydrogen peroxide, sodium bisulfite or sodium sulfite, with a subsequent hydrogen peroxide bleaching stage, resulted in an improved bleached brightness of about 81.6% ISO, i.e. the loss of brightness due to heat was still approximately 2% ISO. Sodium borohydride (1%) did not suppress the thermal darkening but improved the bleached brightness by approximately 2% ISO compared to the heat-treated SGW pulp and resulted in a brightness of 82.6% ISO. Addition of a chelating agent (DTPA, 0.11 and 0.45%) and the radical scavengers phthalic hydrazide (1%) and 1-hexanol (1%) suppressed the heat-induced darkening somewhat but did not improve the hydrogen peroxide bleachability to any noticeable extent. Addition of citric acid (0.6%) did not suppress the thermal darkening and resulted in impaired bleachability.
Investigation of nonlinearities in the force control of real robots (1992)

Some practical issues associated with the force control of manipulators are investigated. How the stability of a force controlled system is affected by a variety of inherent manipulator nonlinearities, such as control signal saturation, slip-stick friction, and sampled-data controller implementation is examined. In order to improve stable system performance, the inclusion of a high gain inner position loop with environmental force compensation is explored. It is demonstrated that the inclusion of the inner position loop will minimize the effects due to slip-stick friction and thereby improve the predictability in the steady-state error. A discrete-time, nonlinear robotic plant model suitable for force control investigations is developed and is demonstrated to provide an accurate prediction of actual system responses. Theoretical conclusions are supported by experiments performed with the PUMA 560 industrial robot testbed facility developed at Colorado State University.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Monitoring the Degradation of 4-Sulfonyldipenyl-Pyromellitic Dianhy-dride-Based Polyamic Acid by Trametes Versicolor (2019)

Polyamic acid (PAA) polymers have been utilized over 60 years in industry as precursors of polyimide, and currently direct utilization of PAA polymers have got great attention for material science applications. Mass utilization of synthetic polymers pose threat to living organisms and nature, so their effective degradation is important. In this study, for the first time, degradation of 4-sulfonyldipenyl-pyromellitic dianhydride based PAA (DSPAA) polymers were performed in batch bioreactor system. 1H COSY NMR was utilized to enlight the possible mechanism behind Tramates versicolor mediated degradation of DSPAA polymer. Elimination of aromatic peaks belong to DSPAA polymer and its amine monomer were monitored to evaluate the degradation while formation of new peaks was taken into account to propose possible degradation pathway. NMR studies revealed that 20-day incubation in the designed media is enough to totally eliminate 1 mg/mL DSPAA. The findings can contribute to the knowledge of fungi mediated aromatic polymer degradation, which is accepted a promising way to eliminate polymer pollution
Resource Teachers Learning and Behaviour: An Ecological Approach to Special Education (2000)

The Resource Teachers Learning and Behaviour (RTLB) program is a unique special education development in New Zealand. The aim of this program is the creation of a nation-wide network of more than 700 RTLB operating as itinerant consulting teachers providing support in inclusive classrooms. The principles underlying the program are described and an outline provided of the curriculum and methods of delivery. The program also acknowledges the need to address the important bi-cultural elements of New Zealand society. The paper reports on RTLB demographic profiles and the initial responses of teachers to their training. Preliminary indices of program effectiveness are also presented. The paper indicates ways in which the RTLB initiative is likely to develop and notes issues within the New Zealand education system that will both strengthen and constrain the overall development of the program.
CORBA Lacks Venom (1999)

Distributed objects bring to distributed computing such desirable properties of modularisation, abstraction and reuse easing the burden of development and maintenance by diminishing the gap between implementation and real-world objects. Distributed objects, however, need a consistent framework in which inter-object communication may take place. The Common Object Request Broker Architecture (CORBA) is a distributed object standard. CORBA's primary protocol is the Internet Interoperable Object Protocol limited to blocked synchronous remote procedure calls, over TCP/IP which is inappropriate for systems requiring timely guarantees.
System Architecture for Device and Content Independent Communication Including 3D Imaging (2013)

Abstract Network landscape of recent time contains many different network technologies, a wide range of end-devices with a large scale of capabilities and power, and an immense quantity of information and data represented in different formats. Research on 3D imaging, virtual reality and holographic techniques will result in new user interfaces (UI) for mobile devices, will increase their diversity and variety. In this paper software architecture has been proposed to establish device and content format independent communication including 3D imaging and virtual reality data as content. As experimental validation the concept is implemented in collaborative Language Learning Game (LLG), which is a learning tool for language acquisition.
Reflections on the Development of International Trade of Education (2004)

With the internationalization and market-oriented development of education, international trade of education has been developing rapidly. The trend will affect our country's education greatly. The article studies the actuality of international trade of education and analyses the advantages of education trade. The article suggests that China's educational departments should set up market consciousness and progress the quality to meet the international education competition.