gebhart/patrepeval huggingface dataset:
Adrenomedullin Does Not Inhibit Human Platelet Aggregation (1998)

BACKGROUND: Adrenomedullin (ADM) is a hypotensive peptide isolated from human pheochromocytoma extracts discovered in 1993 using an assay system designed to monitor its ability to increase rat platelet adenosine 3',5'-cyclic monophosphate (cAMP) levels. Physiological mediators that elevate cAMP levels, such as prostaglandin (PG)E(1) and PGI(2), have also been shown to inhibit platelet aggregation. Therefore, we have chosen to investigate the effect of ADM, a peptide shown to increase platelet cAMP levels, on human platelet aggregation. METHODS AND RESULTS: Platelet-rich plasma prepared from blood donors was incubated with ADM (10(-9)-10(-6) M) for 1 min at 37 degrees C before the addition of a submaximal dose of adenosine 5'-diphosphate (ADP). ADM did not alter the platelet aggregatory response to ADP. PGE(1), a substance known to inhibit ADP-induced platelet aggregation (10(-6) M), however, inhibited ADP-induced platelet aggregation. In addition, the ADM induced a dose-dependent relation in rings of human chorionic arteries. CONCLUSIONS: These data may be interpreted to suggest that human platelets do not possess a functional ADM receptor couple with adenylate cyclase.
AIDS and the death receptors (1997)

Activation-induced cell death (AICD) of T cells involves the CD95 receptor/ligand system. T cell activation through the T cell receptor results in expression of the CD95 ligand (CD95L) that acts on CD95+ cells by direct binding and in a paracrine or autocrine fashion. In AIDS, upregulation of CD95L in T cells is accelerated by two viral gene products, HIV-1 Tat and gp120. The CD95 signaling pathway is, therefore, likely to represent an important road to cell death of the CD4+ T cells in AIDS. Recently, the early events in the CD95 signaling pathway have been identified. A key role hereby plays a receptor-interacting member of the interleukin 1 beta-converting enzymes (ICE), FLICE, that could be a target for therapeutic intervention. In addition to CD95, the role of other members of the TNF receptor superfamily in AIDS is discussed.
The Use of Biofiltration for Further Wastewater Treatment (1984)

The City of Mannheim (FRG) expanded its one stage biological treatment plant by addition of a second stage based on dry bed filtration and designed for an average wastewater flow of QTW = 8.800 m3/h and an average BOD5 of 70 mg/l. Five firms in the foreground of process selection conducted from 1980 to 1982 experiments on purification systems for the effluent from the first biological stage. Systems tested were biofiltration in dry and submerged beds and activated two sludge systems. Filter materials used were inert material, activated carbon and Biolite. In one case a pretreatment by coagulation was employed. The influent of submerged filters without coagulation was supplied with technical oxygen whereas submerged filters with coagulation were supplied with atmospheric oxygen. The two sludge process employed a plastic medium (Flocor E) in an aeration tank of up to 40% total bed volume; aeration was achieved with compressed air. The results of the submerged filtration tests are compared to those of the two sludge system with respect to retention of suspended solids, elimination of BOD5 and COD and soluble and total nitrogenous compounds. A procedural evaluation and cost comparison are made. In addition the problems that arise by solution of oxygen up to high concentrations are indicated and solution possibilities discussed.
Feature reduction for improved recognition of subcellular location patterns in fluorescence microscope images (2003)

The central goal of proteomics is to clarify the mechanism by which each protein in a given cell type carries out its function. Automated protein subcellular location determination by fluorescence microscopy can play an important role in fulfilling this goal. The subcellular location of a protein is critical to understanding its function because each subcellular compartment has a unique biochemical environment. We have previously shown that neural network classifiers using sets of numerical features computed from fluorescence microscope images were able to recognize all major subcellular location patterns with reasonable accuracy. Current classifiers are limited by under-determined classification boundaries due to the limited number of available images compared to the number of features. In this paper, we compare various feature reduction methods that can address this problem. Specifically, principal component analysis, kernel principal component analysis, nonlinear principal component analysis, independent component analysis, classification trees, fractal dimensionality reduction, stepwise discriminant analysis, and genetic algorithms are used to select feature subsets that are evaluated using support vector machine classifiers. The best results were obtained using stepwise discriminant analysis and we found that as few as eight features can provide good classification accuracy for all major subcellular patterns in HeLa cells.
1,25D3 Enhances antitumor activity of gemcitabine and cisplatin in human bladder cancer models (2010)

1,25D3 potentiates gemcitabine and cisplatin-mediated growth inhibition in human bladder cancer models in vitro and in vivo, which involves p73 induction and apoptosis.
An edge detection approach to digital image stabilization based on tri-state adaptive linear neurons (1991)

A novel approach to digital image stabilization (DIS) for video cameras is proposed. The proposed DIS system is composed of an edge detection unit, a motion detection unit, and a digital zooming unit. The edge detection unit is based on tristate adaptive linear neurons, the motion detection unit is based on the corresponding binary logical correlation computations instead of multiple-bit pixel-wise subtractions, and the digital zooming unit is based on the approximated bilinear interpolation technique. A motion decision procedure is also proposed for removing unwanted effects on the integrated motion vector. The proposed DIS system is designed mainly for hardware minimization without using additional Micoms in a video camera system. Experimental results show that the proposed system accurately detects and compensates for camera motion.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
<title>Real Time Measurement Of Index And Geometry Changes By Parallelism Interferometry</title> (1983)

Real time measurement will be reported on the time variations of both the refractive index and geometry of transparent samples. The temperatures of the samples were varied while they were in a parallelism interferometer and the two independent sets of fringe patterns were monitored. One pattern gave the geometric variation, while the others gave the optical path profile. Resolution of quarter wave are readily realized.
ATP as Building Blocks for the Self-Assembly of Excitonic Nanowires (2005)

Supramolecular nanowires are specifically self-assembled from adenosine 5'-triphosphate (ATP) and dichloro-substituted thiacarbocyanine dyes. Spectral blue-shift and induced circular dichroism with exciton coupling are observed upon mixing the dye and ATP molecules in water. These observations indicate the formation of chiral 1/ATP supramolecular assemblies with excitation energy delocalized in the parallel-oriented (H-aggregated) chromophores. Interestingly, formation of H-aggregates is facilitated most in the presence of ATP and not by other nucleotides (ADP or AMP). In electron microscopy, aqueous 1/ATP mixture gives developed nanowires with a minimum width of ca. 10 nm and lengths of several micrometers. The ATP-directed nanowires exhibit reversible thermal self-assembly accompanied by supramolecular thermochromism. This is the first example of ATP-based supramolecular nanoassemblies, and the use of small biomolecules as building blocks for functional supermolecules provides a new perspective in the design of bio-nanomaterials.
Strain-induced spin relaxation anisotropy in symmetric (001)-oriented GaAs quantum wells (2011)

We show experimentally, using spin quantum beat spectroscopy, that strain applied to an undoped symmetric (001) GaAs/AlGaAs multiple quantum well causes an in-plane anisotropy of the spin-relaxation rate ${\ensuremath{\Gamma}}^{s}$, but leaves the electron Land\'e $g$ factor isotropic. The spin-relaxation-rate anisotropy gives a direct measure of the bulk inversion asymmetry and the strain contributions to the conduction-band spin splitting. The comparison of the measured strain-splitting coefficient ${C}_{3}$ for the quantum well with the value for bulk GaAs suggests a dependence on electron quantum confinement. The isotropic $g$ factor implies a symmetric conduction electron wave function, whereas the anisotropic spin-relaxation rate requires a nonzero expectation value of the valence-band potential gradient on the conduction-band states. Therefore, the experiment suggests that strain generates an effective valence-band potential gradient, while the conduction-band potential remains symmetrical to a good approximation.
A 1V RF SoC with an 863-to-928MHz 400kb/s radio and a 32b Dual-MAC DSP core for Wireless Sensor and Body Networks (2010)

A 150¿A/MHz DSP with two MAC/cycle instructions is integrated with a configurable 863-to-928MHz RF transceiver that yields 3.5mW in continuous reception, 2¿C per channel sampling and 40mW for 10dBm output. The SoC includes voltage converters that allow 1.0-to-1.8V or 2.7-to-3.6V primary voltage supplies. In sleep mode, it consumes 1¿A with a 32kHz crystal-based RTC running.
Clipping of bilateral MCA aneurysms and a coiled ACOM aneurysm through a modified lateral supraorbital craniotomy (2015)

We showcase the microsurgical clipping of a left middle cerebral artery (MCA) aneurysm-(B) done through a modified right lateral supraorbital craniotomy, as well as clipping of a previously coiled anterior communicating (ACOM) artery aneurysm-(C) and a bilobed right MCA aneurysm-(A). Splitting of the right sylvian fissure is initially performed following which a subfrontal approach is used to expose and dissect the contralateral sylvian fissure. The left MCA aneurysm is identified and clipped. The ACOM aneurysm is then clipped following multiple clip repositioning based on flow measurements. The right MCA aneurysm is then identified and each lobe is clipped separately. The first picture showcased in this video is a side to side right and left ICA injection in AP projection. In this picture, (A) points to the bilobed right MCA aneurysm, (B) to the left middle cerebral artery (MCA) aneurysm, and (C) to the previously coiled anterior communicating (ACOM) artery aneurysm. The red dotted line shows that both MCA aneurysms lie within the same plane which makes it easier to clip both of them, through one small craniotomy. The video can be found here: http://youtu.be/4cQC7nHsL5I .
A Context-Based Delegation Access Control Model for Pervasive Computing (2007)

This paper presents an architectural model for contextual-based delegation access control for pervasive computing, particularly access control mechanisms for ad hoc coalition scenarios. Coalition access control encompasses control mechanisms dealing with access between multiple heterogeneous entities from different security domains. For pervasive computing these coalitions are formed in an ad hoc manner and need to be sensitive to the context of the participating entities. An architecture model called the SIP session-based coalition access control architecture (SCACA) is presented that extends the SIP signaling model in order to support long distance delegation access control. The result is an architecture that supports spontaneous ad hoc coalitions for a pervasive computing environment.
Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis (2009)

Inflammation is a necessary albeit insufficient component of tumorigenesis in some cancers. Infectious agents directly implicated in tumorigenesis have been shown to induce inflammation. This process involves both the innate and adaptive components of the immune system which contribute to tumor angiogenesis, tumor tolerance and metastatic properties of neoplasms. Recently, heat-shock proteins have been identified as mediators of this inflammatory process and thus may provide a link between infection-mediated inflammation and subsequent cancer development. In this review, the role of heat-shock proteins in infection-induced inflammation and carcinogenesis will be discussed.
High-frequency switching in Candida strains isolated from vaginitis patients (1987)

High-frequency switching and strain variability at the site of infection was assessed in 11 patients with acute Candida albicans vaginitis. By cloning cells directly from the site of infection, it was demonstrated that 4 of the 11 isolates contained multiple-switch phenotypes at the site of infection and that 9 of the 11 isolates were in a high-frequency mode of switching (10(-2) to 10(-3)). Isolates could be separated into four general categories of switching repertoires. To demonstrate that multiple phenotypes at the site of a single infection represented the same strain, EcoRI digests of total cell DNA were separated on agarose gels, and Southern hybridization patterns with two cloned midrepeat sequences were compared.
Cyclic guanidines. II. Synthesis of hypoglycemic acyl or alkyl derivatives of 1-substituted 2-imino-1,3-diazacycloalkane. (1978)

Synthesis of acyl and alkyl derivatives of 1-benzyl or 1-benzhydryl-2-imino-1, 3-diazacycloalkanes (1) was attempted. Acetylation of 1a, c having five-membered ring with ethyl acetate gave 2-acetyl derivatives. However, reactions of 1a, c with dialkylcarbonate, acyl chloride and alkyl or aryl isocyanate afforded a mixture of 2- and 3-substituted compounds and reactions of 1a, c with isothiocyanate derivatives gave predominantly 3-substituted compounds. On the other hand, 1b, d having six-membered ring gave predominantly 2-substituted compounds by the similar reactions. Direct alkylation of 1a, c with alkyl iodide in the presence of sodium hydride yielded 3-alkyl derivatives (5). In the similar alkylations, 2-alkoxycarbonylimino and 2-cyanoimino derivatives, 2 and 9, gave 3-alkyl compounds 7 and 8, in which 2-alkaxycarbonyl and 2-cyano groups were removed on heating in t-butanol containing a small amount of hydrochloric acid to give 5 in good yields. Heating 7 and 8 having 1-benzhydryl group with sodium hydride gave 2-oxo- or 2-imino-3, 3-diphenylimidazo [1, 2-a] [1, 3] diazacycloalkane derivatives (10, 11 and 12). Some of 1-substituted 3-acyl and 3-alkyl-2-imino-1, 3-diazacycloalkanes showed hypoglycemic activity.
In vivo and in vitro characterization of protein interactions with the dyad G-box of the Arabidopsis Adh gene. (1990)

Expression of the alcohol dehydrogenase (Adh) and ribulose-1,5-bisphosphate carboxylase small subunit (RbcS) genes of higher plants is cell-type-specific and environmentally inducible. However, the tissues in which these two genes are expressed, their modes of induction, and their protein functions are quite distinct. Adh is expressed in non-green tissue, induced by anaerobiosis, and repressed in leaves. RbcS is only expressed in green tissue. An 8-base pair G-box element (5'-CCACGTGG-3') is associated with light-induced expression of RbcS and chalcone synthase. The same sequence is also present in the 5'-flanking region of Arabidopsis thaliana Adh, and this sequence is associated with a trans-acting factor in vivo. We report here that in vitro Adh G-box binding activity is present in crude whole cell extracts of both cell culture and leaves of Arabidopsis. The authenticity of in vitro Adh G-box binding is supported by in vivo and in vitro dimethylsulfate footprinting. A clear in vivo Adh G-box footprint occurs in cell cultures, but comparable in vivo binding to the Adh G-box does not occur in leaves. Therefore, there does not appear to be a direct correlation between the presence of the G-box factor in a tissue and its binding to the Adh G-box.
Engineering of cellobiose phosphorylase for the defined synthesis of cellotriose (2020)

Cellodextrins are non-digestible oligosaccharides that have attracted interest from the food industry as potential prebiotics. They are typically produced through the partial hydrolysis of cellulose, resulting in a complex mixture of oligosaccharides with a varying degree of polymerisation (DP). Here, we explore the defined synthesis of cellotriose as product since this oligosaccharide is believed to be the most potent prebiotic in the mixture. To that end, the cellobiose phosphorylase (CBP) from Cellulomonas uda and the cellodextrin phosphorylase (CDP) from Clostridium cellulosi were evaluated as biocatalysts, starting from cellobiose and α-D-glucose 1-phosphate as acceptor and donor substrate, respectively. The CDP enzyme was shown to rapidly elongate the chains towards higher DPs, even after extensive mutagenesis. In contrast, an optimised variant of CBP was found to convert cellobiose to cellotriose with a molar yield of 73%. The share of cellotriose within the final soluble cellodextrin mixture (DP2-5) was 82%, resulting in a cellotriose product with the highest purity reported to date. Interestingly, the reaction could even be initiated from glucose as acceptor substrate, which should further decrease the production costs.Key points• Cellobiose phosphorylase is engineered for the production of cellotriose.• Cellotriose is synthesised with the highest purity and yield to date.• Both cellobiose and glucose can be used as acceptor for cellotriose production.
Lack of Ir gene control in the immune response to malaria. I. A thymus-independent antibody response to the repetitive surface protein of sporozoites. (1990)

The anamnestic antibody response to synthetic peptide antimalarial vaccines is under Ir gene control. It has therefore been inferred that the development of antibody responses to the native repetitive Ag of malaria parasites also requires linkage of T and B cell epitopes, presentation of Ag in the context of MHC class II components, and cognate T cell help for antibody production. In this study, we sought to test this assumption, by utilizing classical protocols to determine whether the antibody response to the repetitive surface Ag of malaria sporozoites, the circumsporozoite (CS) protein, is under Ir gene control. In contrast to vaccine constructs, such as recombinant proteins or synthetic peptides, secondary responses to the repetitive oligomeric domains of the native CS protein of intact malaria sporozoites do not require the presence of Ag-specific Th cells. Conferral of CS-specific Th cells does not appear to influence the magnitude of this thymus-independent response to sporozoites. In further contrast to synthetic CS analogs, exposure to the parasite appears to be associated with low levels of Ag-specific Th cell sensitization. These observations suggest a functional role in immune evasion for the immunodominant repetitive domains found within protein Ag of malaria and other parasites.
Reduction of Carbon Dioxide in Hydrothermal Cracking of Polymer Wastes (2011)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationReduction of Carbon Dioxide in Hydrothermal Cracking of Polymer WastesXu Zeng†, Fangming Jin*‡, Zhibao Huo†, Takeo Mogi‡, Atsushi Kishita‡, and Heiji Enomoto‡View Author Information† State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, People's Republic of China‡ Graduate School of Environmental Studies, Tohoku University, Sendai 980-8579, JapanE-mail: [email protected]Cite this: Energy Fuels 2011, 25, 6, 2749–2752Publication Date (Web):May 16, 2011Publication History Received25 March 2011Revised16 May 2011Published online17 May 2011Published inissue 16 June 2011https://pubs.acs.org/doi/10.1021/ef200440khttps://doi.org/10.1021/ef200440krapid-communicationACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views615Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Deformation,Hydrocarbons,Hydrogen,Organic acids,Redox reactions Get e-Alerts
Developing a model of robot behavior to identify and appropriately respond to implicit attention-shifting (2009)

In this paper, we present our current research on developing a model of robot behavior that leads to feelings of being together using the robot's body position and orientation. Creating feelings of"being together"will be an essential skill for robots that live with humans and adapt to daily human activities such as walking together or establishing joint attention to information in the environment. We observe people's proxemic behavior in joint attention situations and develop a model of behavior for robots to detect a partner's attention shift and appropriately adjust its body position and orientation in establishing joint attention with the partner. We experimentally evaluate the effectiveness of our model, and our results demonstrate the model's effectiveness.
Insulin lispro: a useful advance in insulin therapy (2003)

AbstractInsulin lispro, the first insulin analogue to be used clinically, was engineered to incorporate the pharmacological advantages of insulin-like growth factor-1 (IGF-1), which has a reduced tendency to self associate, compared to conventional soluble insulin. It is absorbed more quickly following a subcutaneous injection, reaching peak concentrations (approximately twice as much as conventional insulin) and then falls more rapidly. These more physiological insulin profiles are reflected in the results of clinical trials involving patients with Type 1 diabetes, which generally show comparable glycaemic control but reduced rates of hypoglycaemia, particularly at night. The reduction in the rate of hypoglycaemia in the early trials has been generally fairly modest, but more recent publications suggest that increasing experience and more individualised insulin adjustment may lead to a greater impact. Other indications include its use in continuous subcutaneous insulin infusion and postprandially in young children.Keywordshypoglycaemiainsulin analogueinsulin lispro