gebhart/patrepeval huggingface dataset:
Hyaluronan receptors are expressed on human malignant mesothelioma cells but not on normal mesothelial cells. (1994)

Hyaluronan-binding sites were demonstrated on the cell surface of three malignant mesothelioma cell lines derived from human tumors using either [3H]hyaluronan or fluorescein-tagged hyaluronan. No hyaluronan-binding activity was observed on normal human mesothelial cells. The absence of hyaluronan receptors on normal human mesothelial cells was not due to a down-regulation by endogenously synthesized hyaluronan, since no binding sites appeared when the cells were cultured under conditions known to suppress hyaluronan synthesis (in starvation medium containing either hydrocortisone or n-butyrate) or to degrade endogenously synthesized hyaluronan (in the presence of Streptomyces or testicular hyaluronidase). The binding of [3H]hyaluronan on mesothelioma cells could be partially inhibited by prior incubation of the cells with trypsin, indicating that the hyaluronan-binding site is a protein. The binding sites on human malignant mesothelioma cells were shown to be saturable with about 54,000 hyaluronan molecules (M(r) 1.4 x 10(6)) bound per cell with a Kd of 0.3 x 10(-9) M. The binding was specific for hyaluronan inasmuch as a number of other macromolecules gave negligible inhibition of the binding. High molecular weight preparations of hyaluronan inhibited the binding more effectively than low molecular weight preparations; hyaluronan oligosaccharides down to a length of six monosaccharide units showed competing activity. The hyaluronan receptor appeared to be related to CD44 (a cell surface glycoprotein previously suggested to function as a hyaluronan receptor) since Hermes-1 monoclonal antibodies which inhibit the binding of hyaluronan to CD44 blocked a major part of the binding of hyaluronan to the mesothelioma cells. However, there was no strict correlation between the hyaluronan-binding activity on the mesothelioma cell lines tested and the levels of CD44 molecules on their cell surface, suggesting that only a subfraction of the CD44 molecules bound hyaluronan or that other hyaluronan-binding proteins also exist on those cells. The presence of hyaluronan receptors on mesothelioma cells, but not on their normal counterparts, may be of importance for the migration of the transformed cells in hyaluronan-enriched matrices and for their ability to form metastases.
Downlink Asynchronous Non-Orthogonal Multiple Access With Quantizer Optimization (2020)

In this letter, we study a two-user downlink asynchronous non-orthogonal multiple access (ANOMA) with limited feedback. We employ the max-min criterion for the power allocation and derive the closed-form expressions for the upper and lower bounds of the max-min rate. It is demonstrated that ANOMA can achieve the same or even higher average max-min rate with a lower feedback rate compared with non-orthogonal multiple access (NOMA). Moreover, we propose a quantizer optimization algorithm which applies to both NOMA and ANOMA. Simulation results show that the optimized quantizer significantly improves the average max-min rate compared with the conventional uniform quantizer, especially in the scenario with a low feedback rate.
Hybrid Automatic Repeat Request for Downlink Rate-Splitting Multiple Access (2023)

This work investigates the design of Hybrid Automatic Repeat Request (HARQ) strategies for downlink Rate-Splitting Multiple Access (RSMA). The existence of private and common stream as well as their conditioning for Successive Interference Cancellation (SIC), gives rise to an expanded set of opportunities for retransmission of failed packets. Specifically, we devise a scheme in which the retransmissions are scheduled through the common stream, which offers a higher success probability. With this, the common stream needs to carry both new and retransmitted bits, which leads to a layered HARQ (L-HARQ) strategy which is capable of trading off throughput and reliability. Simulation results demonstrate that the devised HARQ scheme outperforms RSMA with conventional HARQ, where each retransmission is handled independently through its own stream. It also helps in closing the throughput gap between HARQ and Adaptive Modulation and Coding (AMC) in the high Signal-to-Noise Ratio (SNR) regime while also achieving a decreased Packet Error Rate (PER) and a lower latency.
RESPOSTAS AGUDAS DE VARIÁVEIS CARDIOVASCULARES EM PACIENTES HIPERTENSOS SUBMETIDOS A UM PROGRAMA DE EXERCÍCIOS TERAPÊUTICOS (2013)

Responses to acute cardiovascular variables in hypertensive patients undergoing a program of therapeutic exercises Objective: To evaluate the effects after treatment and the benefits of participation in hypertensive patients in a supervised program of therapeutic exercises. Method: Patients were submitted to a kinetic-functional evaluation; measurements of height and weight; analysis of resting heart rate (RHR) and measurement of blood pressure (BP). The intensity of training was done by calculating the heart rate training (HRT), between 60% and 75% heart rate reserve (HRR) and indirect value of VO2 demarcated by pulse frequency meters. Results: There was a reduction of the values of resting heart rate, systolic blood pressure and systolic maximum pressure with significant increase in VO2 after the period of indirect intervention. Conclusions: The program supervised therapeutic indices obtained significant acute change in cardiovascular variables.
Infrared Spectroscopic Characterization of [2]Rotaxane Molecular Switch Tunnel Junction Devices (2006)

Langmuir-Blodgett monolayers of a bistable [2]rotaxane were prepared at packing densities of 118, 73, and 54 A(2)/molecule. The monolayers were both characterized via infrared spectroscopy before and after evaporation of a 2 nm film of titanium and incorporated into molecular switch tunnel junction devices. The study suggests that the evaporation process primarily affects portions of the molecule exposed to the metal atom source. Thus, in tightly packed monolayers (73 and 54 A(2)/molecule), only the portions of the [2]rotaxane that are present at the molecule/air interface are clearly affected, leaving key functionality necessary for switching intact. Monolayers transferred at a lower pressure (118 A(2)/molecule) exhibit nonspecific damage and poor switching behavior following Ti deposition. These results indicate that tightly packed monolayers and sacrificial functionality displayed at the molecule/air interface are important design principles for molecular electronic devices.
Both homodimeric isoforms of PDGF (AA and BB) have mitogenic and chemotactic activity and stimulate phosphoinositol turnover (1989)

Platelet-derived growth factor (PDGF) occurs as three dimeric isoforms, AA, BB, and AB, which were previously shown to bind to two receptors with different isoform-specificity, the A/B-type (binds all three isoforms) and the B-type (binds only PDGF-BB). Results from competition binding experiments with Swiss 3T3 cells suggest the existence of a third receptor type, which recognizes PDGF-AB and PDGF-BB. Furthermore, Swiss 3T3 cells and human dermal fibroblasts express different relative and absolute levels of these receptor types. In particular, Swiss 3T3 cells express 90,000 PDGF-AA binding sites (A/B-receptors) per cell, whereas human fibroblasts express only 20,000 A/B-receptors per cell. All three PDGF isoforms were tested in either cell type for their effect on DNA synthesis. PDGF-BB and PDGF-AA were also tested in Swiss 3T3 cells for their effect on inositol phospholipid metabolism and chemotaxis. Each isoform promoted all three processes dose-dependently, but there were differences in the maximum cellular responses elicited. These responses reflect the capacity of the cells to bind the individual isoforms. These results demonstrate that the previous distinctions in responsiveness to the different PDGF isoforms are primarily a consequence of the differences in the levels of surface expression of the various isoform-specific receptor types, rather than of the differences in the intrinsic activity of these isoforms. Furthermore, these results suggest that all types of PDGF receptors are capable of responding to their respective ligands by mediating phosphoinositide breakdown, chemotactic responses, and DNA synthesis. Whether they exhibit other functional differences remains to be seen.
The Labelling of Phosphomonoester End Groups in Amino Acid Acceptor Ribonucleic Acids and its use in the Determination of Nucleotide Sequences (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Labelling of Phosphomonoester End Groups in Amino Acid Acceptor Ribonucleic Acids and its use in the Determination of Nucleotide SequencesR. K. Ralph, R. J. Young, and H. G. KhoranaCite this: J. Am. Chem. Soc. 1962, 84, 8, 1490–1491Publication Date (Print):April 1, 1962Publication History Published online1 May 2002Published inissue 1 April 1962https://pubs.acs.org/doi/10.1021/ja00867a030https://doi.org/10.1021/ja00867a030research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Flexible Organic Transistors with Controlled Nanomorphology (2015)

We report the controlled nanomorphology of semiconducting polymers on chemically and mechanically stable nanogrooved polymer substrates. By employing silicon dioxide thin films with finely adjusted thicknesses on nanogrooved polymer substrates, semiconducting polymer thin films oriented and aligned along the nanogrooves were obtained. Organic field-effect transistors (OFETs) fabricated from the oriented semiconducting polymer, poly[4-(4,4-dihexadecyl-4H-cyclopenta[1,2-b:5,4-b']dithiophen-2-yl)-alt-[1,2,5]thiadiazolo-[3,4-c]pyridine] (PCDTPT), yielded saturation hole mobilities as high as 19.3 cm(2) V(-1 )s(-1), and the flexible "plastic" transistors demonstrated excellent mechanical stability under various bending conditions. These results represent important progress for solution-processed flexible OFETs and demonstrate that directed self-assembly of semiconducting polymers can be achieved by soft nanostructures.
Desiccation-Induced Structuralization and Glass Formation of Group 3 Late Embryogenesis Abundant Protein Model Peptides (2009)

Anhydrobiotic (i.e., life without water) organisms are known to produce group 3 late embryogenesis abundant (G3LEA) proteins during adaptation to severely water-deficient conditions. Their primary amino acid sequences are composed largely of loosely conserved 11-mer repeat units. However, little information has been obtained for the structural and functional roles of these repeat units. In this study, we first explore the consensus sequences of the 11-mer repeat units for several native G3LEA proteins originating from anhydrobiotic organisms among insects (Polypedilum vanderplanki), nematodes, and plants. Next, we synthesize four kinds of model peptides (LEA models), each of which consists of four or two repeats of the 11-mer consensus sequences for each of the three organisms. The structural and thermodynamic properties of the LEA models were examined in solution, in dehydrated and rehydrated states, and furthermore in the presence of trehalose, since a great quantity of this sugar is known to be produced in the dried cells of most anhydrobiotic organisms. The results of Fourier transform infrared (FTIR) spectroscopic measurements indicate that all of the LEA models transform from random coils to alpha-helical coiled coils on dehydration and return to random coils again on rehydration, both with and without trehalose. In contrast, such structural changes were never observed for a control peptide with a randomized amino acid sequence. Furthermore, our differential scanning calorimetry (DSC) measurements provide the first evidence that the above 11-mer motif-containing peptides themselves vitrify with a high glass transition temperature (>100 degrees C) and a low enthalpy relaxation rate. In addition, they play a role in reinforcing the glassy matrix of the coexisting trehalose. On the basis of these results, we discuss the underlying mechanism of G3LEA proteins as desiccation stress protectants.
Glucose enzyme electrode with percutaneous interface which operates independently of dissolved oxygen (1989)

An enzyme glucose electrode that operates even when no oxygen is dissolved in the glucose solution has been developed and its in vitro performance evaluated. The electrode has been designed to be used with a percutaneous interface for future in vivo use. Oxygen is supplied to the electrode from the atmosphere. The electrode is based on the conventional H2O2 detecting enzyme electrode, in which an Ag cylinder 4.5 mm in diameter and 16 mm in length is used as a cathode. A Pt wire 0.5 mm in diameter is fixed in the centre for an anode, and 0.5 mu g of albumin-linked glucose oxidase is immobilised at the tip of the anode. The electrode has a linear response to glucose concentration at an electrode output current ranging from 0 to 20 nA even when the oxygen concentration of the glucose solution is zero. The use of polyurethane as a diffusion barrier to glucose limits the electrode output current at a glucose concentration of 500 mg dl-1 (27.8 mmol 1-1) to 20 nA. Therefore, the electrode can measure glucose concentrations up to 500 mg dl-1 (27.8 mmol 1-1) with no oxygen dissolved in the glucose solution.
Thermal polymerization of a 2-(carboxyalkyl)-2-oxazoline (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal polymerization of a 2-(carboxyalkyl)-2-oxazolinePathiraja A. Gunatillake, George Odian, and Donald A. TomaliaCite this: Macromolecules 1988, 21, 6, 1556–1562Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/ma00184a003https://doi.org/10.1021/ma00184a003research-articleACS PublicationsRequest reuse permissionsArticle Views301Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Numerical Estimation of Blood Damage in Artificial Organs (2004)

The aim of this study was to determine a method for the numerical estimation of blood damage. Normally, human or animal blood is used for in vitro evaluation of lysis by artificial organs. However, blood has some disadvantages: large biological variability and different initial test conditions lead to nonreproducible test results. For that reason, it would be an advantage to have a numerical method for blood damage estimation. This proposed method is based on the calculation of an integrated hemolysis and platelet lysis index along the path line in the flow field of the artificial organ. The time-dependent shear stress related lysis is based on known experimental data. In order to calibrate these data, the method was first applied to blood circulation in the human body. The results showed that the known data overestimate hemolysis by a factor of approximately 25. Next, the method was applied to a standard Björk-Shiley valve. The flow through a valve was simulated with the computational fluid dynamics program FLUENT. The calculation of lysis was added into FLUENT and done automatically. The results showed that the Björk-Shiley valve increased the hemolysis index by 7% if implanted in the human body circulation.
Expression and localization of oxytocin receptor gene in human uterine endometrium in relation to the menstrual cycle. (1993)

The expression of oxytocin receptor mRNA in the human uterus was investigated by polymerase chain reaction after mRNA reverse transcription; in addition, the mRNA was localized by means of in situ hybridization histochemistry. Strong positive signals were observed in myometrial cells at parturition. In nonpregnant human uterine endometrium, oxytocin receptor mRNA was expressed in glandular epithelial cells, but was not observed in stromal cells. The signal in the epithelial cells was stronger at the time of ovulation than during any other phase. The sequential changes in oxytocin receptor mRNA expression in nonpregnant endometrium suggest some alternative biological function of oxytocin in endometrium during the menstrual cycle.
Response of a Bloch oscillator to a THz‐field (1994)

Abstract In this paper we report on the observation of response of a Bloch oscillator at room temperature to a THz‐field of a frequency larger than the Bloch frequency. The oscillator consisted of a semiconductor superlattice structure, with an applied dc voltage giving rise to a dc electron drift current. Submitting the oscillator to a field at a frequency of 3.3 THz caused a sizeable reduction of the current; the THz‐field was generated by use of intense THz‐radiation pulses focused on an antenna coupled to the superlattice. We attribute the THz‐field induced reduction of the current to a frequency modulation of the Bloch oscillations of electrons at the frequency of the THz‐field, leading to reduction of the electron drift velocity and, consequently, of the current.
Monte Carlo Simulations on Atropisomerism of Thienotriazolodiazepines Applicable to Slow Transition Phenomena Using Potential Energy Surfaces by <i>ab initio</i> Molecular Orbital Calculations (2014)

Compounds with a medium-sized flexible ring often show atropisomerism that is caused by the high-energy barriers between long-lived conformers that can be isolated and often have different biological properties to each other. In this study, the frequency of the transition between the two stable conformers, aS and aR, of thienotriazolodiazepine compounds with flexible 7-membered rings was estimated computationally by Monte Carlo (MC) simulations and validated experimentally by NMR experiments. To estimate the energy barriers for transitions as precisely as possible, the potential energy (PE) surfaces used in the MC simulations were calculated by molecular orbital (MO) methods. To accomplish the MC simulations with the MO-based PE surfaces in a practical central processing unit (CPU) time, the MO-based PE of each conformer was pre-calculated and stored before the MC simulations, and then only referred to during the MC simulations. The activation energies for transitions calculated by the MC simulations agreed well with the experimental ΔG determined by the NMR experiments. The analysis of the transition trajectories of the MC simulations revealed that the transition occurred not only through the transition states, but also through many different transition paths. Our computational methods gave us quantitative estimates of atropisomerism of the thienotriazolodiazepine compounds in a practical period of time, and the method could be applicable for other slow-dynamics phenomena that cannot be investigated by other atomistic simulations.
Rheological Investigation of Entangled Hybrid Copolymers of Polystyrene (PS) With Polyhedral Oligosilsesquioxane (POSS) (2004)

Abstract : The thermal properties and rheological behaviors of polystyrene (PS)-based thermoplastics bearing polyhedral oligosilsesquioxane (POSS) were investigated with variation of isobutyl (iBu)-POSS weight percentage. The incorporation of POSS-group significantly decreases the glass transition temperature and the rubbery plateau modulus. These findings are attributed to an influence of the nanometer-scale POSS pendant group on the microscopic topology of the host polymeric chains and negligible interactions between POSS and PS matrix.
Erratum: “Study of the ground multiplet of Kramers rare earth ions in solid matrices by multifrequency electron paramagnetic resonance spectroscopy: Nd3+ in PbWO4 single-crystals” [J. Chem. Phys. 131, 034505 (2009)] (2009)

Study of the ground multiplet of Kramers rare earth ions in solid matrices by multifrequency electron paramagnetic resonance spectroscopy
60 GHz beam selection grid antenna on low cost packaging substrate (2013)

In this paper, a grid antenna with beam selection capability is presented. The antenna covers the entire 60GHz band, from 57 to 64 GHz, and has a gain greater than 11dB over the whole band. With only 3 different feeding points, fed by in-phase and quadrature signals, the antenna can generate 5 beams between −14° to 14° from broadside in steps of 7°. The antenna, fabricated on a low cost packaging substrate, satisfies the requirements of low cost and small size for mass production and is a good candidate for 60GHz LOS communication systems.
The role of oxygen in regulating neural stem cells in development and disease (2009)

Oxygen (O2) is a substrate for energy production in the cell and is a rapid regulator of cellular metabolism. Recent studies have also implicated O2 and its signal transduction pathways in controlling cell proliferation, fate, and morphogenesis during the development of many tissues, including the nervous system. O2 tensions in the intact brain are much lower than in room air, and there is evidence that dynamic control of O2 availability may be a component of the in vivo neural stem cell (NSC) niche. At lower O2 tensions, hypoxia-inducible factor 1alpha (HIF1alpha) facilitates signal transduction pathways that promote self-renewal (e.g., Notch) and inhibits pathways that promote NSC differentiation or apoptosis (e.g., bone morphogenetic proteins). Increasing O2 tension degrades HIF1alpha, thus promoting differentiation or apoptosis of NSCs and progenitors. These dynamic changes in O2 tension can be mimicked to optimize ex vivo production methods for cell replacement therapies. Conversely, disrupted O2 availability may play a critical role in disease states such as stroke or brain tumor progression. Hypoxia during stroke activates precursor proliferation in vivo, while glioblastoma stem cells proliferate maximally in a more hypoxic environment than normal stem cells, which may make them resistant to certain anti-neoplastic therapies. These findings suggest that O2 response is central to the normal architecture and dynamics of NSC regulation and in the etiology and treatment of brain diseases.