gebhart/patrepeval huggingface dataset:
A (De)Composable Theory of Rhythm Perception (1992)

A definition is given of expectancy of events projected into the future by a complex temporal sequence. The definition can be decomposed into basic expectancy components projected by each time interval implicit in the sequence. A preliminary formulation of these basic curves is proposed and the (de) composition method is stated in a formalized, mathematical way. The resulting expectancy of complex temporal patterns can be used to model such diverse topics as categorical rhythm perception, clock and meter inducement, rhythmicity, and the similarity of temporal sequences. Besides expectancy projected into the future, the proposed measure can be projected back into the past as well, generating reinforcement of past events by new data. The consistency of the predictions of the theory with some findings in categorical rhythm perception is shown.
A versatile time-domain Reed-Solomon decoder (1990)

A versatile Reed-Solomon (RS) decoder structure based on the time-domain decoding algorithm (transform decoding without transforms) is developed. The algorithm is restructured, and a method is given to decode any RS code generated by any generator polynomial. The main advantage of the decoder structure is its versatility, that is, it can be programmed to decode any Reed-Solomon code defined in Galois field (GF) 2/sup m/ with a fixed symbol size m. This decoder can correct errors and erasures for any RS code, including shortened and singly extended codes. It is shown that the decoder has a very simple structure and can be used to design high-speed single-chip VLSI decoders. As an example, a gate-array-based programmable RS decoder is implemented on a single chip. This decoder chip can decode any RS code defined in GF (2/sup 5/) with any code word length and any number of information symbols. The decoder chip is fabricated using low-power 1.5- mu , two-layer-metal, HCMOS technology.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Tuning the Rheostat of the Myelopoietic System via Fas and TRAIL (2003)

During the last decade, the concerted effort of numerous scientific groups has expanded our understanding of the finely tuned network present within bone marrow for the regulation of the hematopoietic system. This network, comprising humoral and cellular cross talk, is responsible for the adaptation of hematopoietic populations to demands as they arise. Major components of this control system are death receptors and their specific ligands, which eliminate superfluous cells once they have fulfilled their respective functions. The important role of Fas (CD95/Apo-1), one member of this death receptor family, in the regulation of T- and B-cell functions has been established. Alteration of Fas expression and/or function in lymphoid cells may contribute to the development of autoimmunity and/or neoplastic diseases. In addition to controlling lymphoid compartments, Fas is also involved in the regulation of myeloid cell functions. More recently, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its specific receptors (TRAIL-R) have been identified as further members of this death receptor/ligand family. The TRAIL-R/TRAIL system is of vital importance for the maturation and functioning of immune effector cells of lymphoid, as well as myeloid, origin. In the present review, we have summarized current knowledge about both death receptor/ligand systems in the expansion and functioning of cells from the myeloid compartments, highlighted their role in normal hematopoiesis, and assessed their alterations in pathologic or neoplastic conditions.
Lovers and Other Supernatural Beings (2004)

Act II begins in the cave of the Sorceress with her coven of witches who are plotting Dido's death.Her recitatives are answered by her cackling acolytes in 'Ho, ho, ho!' choruses.The Sorceress unfolds a plot.She will conjure a storm to the ruin the royal couple's hunting party and send them back to Carthage.One of her witches will appear to Aeneas in the form of Mercury and command him to sail away.The concluding chorus 'In our deep vaulted cell' is cast in the popular form of a series of echoes.
Synthesis and characterization of silicon carbide, silicon oxynitride and silicon nitride nanowires (2002)

Several methods have been employed to synthesize SiC nanowires. The methods include heating silica gel or fumed silica with activated carbon in a reducing atmosphere, the carbon particles being produced in situ in one of the methods. The simplest method to obtain β-SiC nanowires involves heating silica gel with activated carbon at 1360 °C in H2 or NH3. The same reaction, if carried out in the presence of catalytic iron particles, at 1200 °C gives α-Si3N4 nanowires and Si2N2O nanowires at 1100 °C. Another method to obtain Si3N4 nanowires is to heat multi-walled carbon nanotubes with silica gel at 1360 °C in an atmosphere of NH3. In the presence of catalytic Fe particles, this method yields α-Si3N4 nanowires in pure form.
Polyreactivity and Autoreactivity among HIV-1 Antibodies (2014)

Eliciting bNAbs is key for HIV-1 vaccines; most Abs elicited by HIV-1 infection or immunization, however, are strain specific or nonneutralizing, and unsuited for protection. Here, we compare the specificities of bNAbs and nNAbs to demonstrate that bNAbs are significantly more poly- and autoreactive than nNAbs. The strong association of poly- and autoreactivity with bNAbs, but not nNAbs from infected patients, indicates that the infection milieu, chronic inflammation and Ag exposure, CD4 T-cell depletion, etc., alone does not cause poly- and autoreactivity. Instead, these properties are fundamentally linked to neutralization breadth, either by the requirement for heteroligation or the consequence of host mimicry by HIV-1. Indeed, we show that human UBE3A shares an epitope(s) with HIV-1 envelope recognized by four CD4bs bNAbs. The poly- and autoreactivity of bNAbs surely contribute to the rarity of membrane-proximal external region (MPER) and CD4bs bNAbs and identify a roadblock that must be overcome to induce protective vaccines.
Werk en netwerk. Tekst en commentaar op de Verhalensite (2011)

die, ondanks de naam, zowel verhalen als gedichten publiceert.De Verhalensite is een Nederlandstalige, in Belgi gebaseerde website waar Nederlanders en Vlamingen gedichten en verhalen publiceren en becommentariren.De site bestaat sinds 2001.De Verhalensite lijkt zich van veel andere sites te onderscheiden door een gemiddeld wat hoger niveau van de inzendingen, door een grote betrokkenheid van de deelnemers bij de site, en door een cultuur van vriendelijke en uitgebreide reacties.
Neutralizing antibody to FGFR2 can act as a selective biomarker and potential therapeutic agent for gastric cancer with FGFR2 amplification. (2019)

<i>Fibroblast growth factor receptor 2</i> (<i>FGFR2</i>) amplification has been reported in 5-10% of gastric cancer (GC) and is associated with poor prognosis. In this study, we characterized the anti-tumor effect of PRO-007, a newly developed recombinant monoclonal antibody that targets FGFR2, in GC cell lines KATO III (with <i>FGFR2</i> amplification) and NCI-N87 (without <i>FGFR2</i> amplification). Validation was performed in parallel using two patient-derived tumor cells (PDCs) from patients with GC. Cell viability assays were performed using <i>FGFR2</i>-transfected NCI-N87 cells and <i>FGFR2</i>-knockdown KATO III cells that were generated using short hairpin RNA (shRNA). PRO-007 reduced KATO III cell viability (P = 0.0034) but not that of NCI-N87 cells (P = 0.3710). PRO-007 also significantly reduced KATO III cell invasiveness (P < 0.0001) but not NCI-N87 cell invasiveness (P = 0.8136). Immunoblot analysis showed that PRO-007 treatment decreased the levels of phosphorylated AKT and ERK. The FGFR2-inhibitory activity of PRO-007 was confirmed in genetically modified GC cell lines. Cell viability of <i>FGFR2</i>-overexpressing NCI-N87 cells was significantly decreased by PRO-007, while KATO III cells were significantly resistant to the treatment when <i>FGFR2</i> was knocked down by FGFR2 shRNA transfection. Furthermore, PRO-007 had a synergistic effect with ramucirumab on the invasiveness of cancer cells with <i>FGFR2</i> amplification. Consistent results were obtained using PDCs from patients with GC. Overall, these preclinical data support the further clinical development of PRO-007 as a potential therapeutic agent for patients with <i>FGFR2</i>-amplified GC.
γ-TRIS: a graph-algorithm for comprehensive identification of vector genomic insertion sites (2019)

Supplementary data are available at Bioinformatics online.
Genetic Variability of the ET-1 and the ETA Receptor Genes in Essential Hypertension (1995)

Because evidence suggests that endothelin-1 (ET-1) plays a role in the pathogenesis of hypertension, we examined the variability within the ET-1 and the ET(A) receptor genes in patients with essential hypertension (EH). Genomic DNA was used for amplification of both genes by PCR. Polymorphisms within these genes were identified by single-strand conformation polymorphism (SSCP) analysis and subsequent DNA sequencing. Single-base insertions (C at position 121; A at position 138) were identified in the untranslated region of exon 1 of the ET-1 gene. The C insertion was invariant, whereas the A insertion, which abolished a BsiY1 restriction site, occurred only in samples that showed altered mobility profiles on SSCP analysis. This strategy also identified a silent polymorphism in codon 323 (CAC-->CAT) of the ET(A) receptor gene, which created an AflII restriction site. The frequency distribution of these polymorphisms was compared in an EH population [diastolic blood pressure (DBP) > or = 95 mm Hg; n = 100] and a matched normotensive (NT) group (BP < or = 140/85 mm Hg). No significant differences in AflII genotype distribution were found between the EH and NT groups. However, chi 2 analysis suggested a significant difference between the BsiY1+/+, BsiY1-/+, and BsiY1-/- genotype frequencies in the two groups (EH 58:38:4%; NT 47:44:9% (p = 0.045)). In addition, two-way analysis showed a strong correlation between DBP and the BsiY1-/- polymorphism. These results suggest that these polymorphisms act as markers for the level of DBP.
Multiplexed electrospray deposition for protein microarray with micromachined silicon device (2007)

Multiplexed electrospray deposition device capable of delivering picoliter volumes made by silicon micromachining technology has been developed as a deposition tool for making protein microarrays in a noncontact mode. Upon application of potential difference in the range of 7–9kV, biomolecules dissolved in suitable buffer with nonionic surfactant and loaded on the electrospray tips were dispensed on the substrate with microfabricated hydrogel features (1–10μm) in cone-jet mode. Schiff base chemistry followed by reductive amination was utilized for covalent immobilization.
Acoustical analysis of mechanical heart valve sounds for early detection of malfunction (2010)

Objective: Mechanical heart valves carry the disadvantage of lifelong antithrombotic therapy, due to the high risk of thrombus formation on the valve surface. Current diagnostic methods are incapable of detecting thrombus formation in an early stage. Our aim is to develop a diagnostic method, based on the analysis of the acoustic signal produced by the valve. This method should be capable of early detection of malfunction, thus permitting targeted medication and reducing valve related complications and mortality. Methods: A measurement setup assuring optimal signal quality was developed, and a software program automating temporal and frequency analysis of the signal was implemented. The method and program were first validated on an in vitro mock circulatory loop. Next, three sheep were implanted with a St. Jude Regent bileaflet valve and one with an Advantage valve. The signal of their valve undergoing thrombosis was assessed on weekly basis before explantation. The four sheep were sacrificed shortly after the first detection of malfunction according to the newly developed method. Different criteria to proceed to explantation were used in the four cases. Results: In each case thrombus or membrane formation was detected on the leaflets upon explantation, which was in accordance with the analysis results that had predicted a certain level of malfunctioning. Conclusions: Acoustical analysis of mechanical heart valves permits early detection of valvular malfunction. Temporal analysis is a more straightforward method than frequency analysis, but its detection capabilities are slightly less sensitive. Further research with more in vitro and animal testing is required to statistically validate these findings.
SAR/Inertial Integration for GPS-Denied Navigation (2016)

This paper describes integrated SAR/inertial mechanization for navigation in GPS-degraded and GPS-denied environments. The integrated solution fuses SAR and inertial data at signal processing and measurement levels. The paper describes algorithms developed and applies simulated and experimental data to demonstrate their feasibility.
On a robust nonlinear servomechanism problem (1994)

A notion of kth-order robust control for the nonlinear servomechanism problem is introduced. A transmission zeros condition is given for the existence of a kth-order robust control law such that, regardless of small parameter perturbations of the plant and control law, the closed-loop system will induce a stable invariant manifold with the error map zero up to kth-order at each point of the manifold. Such a control law incorporates an internal model of up to k subsystems determined by the exosystem. A special case of the result of this paper recovers the well-known linear robust servomechanism result.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Strong nuclear factor‐κB‐DNA binding parallels cyclooxygenase‐2 gene transcription in aging and in sporadic alzheimer's disease superior temporal lobe neocortex (1998)

Cyclooxygenase-2 (COX-2; EC 1.14.99.1) RNA message abundance in 25 control and Consortium to Establish a Registry for Alzheimer's Disease (CERAD)-confirmed sporadic Alzheimer's disease (AD) brains is remarkably heterogeneous when compared with 55 other AD brain RNA message levels that were previously characterized (Lukiw and Bazan: J Neurosci Res 50:937–945, 1997). Examination of nuclear protein extracts (NPXTs) that were derived from control and AD-affected brain neocortical nuclei (n = 20; age range, 60–82 years; postmortem interval, 0.5–6.5 hours) by using gel shift, gel supershift, and cold oligonucleotide competition assay revealed a highly significant relationship between the extent of inflammatory transcription factor, nuclear factor (NF)-κB: DNA binding and the abundance of the COX-2 RNA signal (P < 0.0001; analysis of variance). No strong correlation with AP-1-DNA binding was noted (P > 0.045). These data are the first linking inflammation-related transcription factor NF-κB-DNA binding to up-regulation of transcription from a key inflammatory gene, COX-2, in both normally aging brain and in AD-affected neocortex. Systematic deletion of NF-κB-DNA binding sites in human COX-2 promoter constructs attenuates COX-2 transcriptional induction by mediators of inflammation. Strong NF-κB-DNA binding has been reported previously to temporally precede COX-2 gene transcription in human epithelial (A549), hamster B-cell (HIT-T15), human endothelial (HUVEC), human lymphoblast (IM9), human fibroblast (IMR90), rat glioma/mouse neuroblastoma (NG108–15), human keratinocyte (NHEK), mouse fibroblast (NIH 3T3), rat neuroblastoma (SH-SY5Y) cell lines and in mouse and rat brain hippocampus, indicating a highly conserved inflammatory signaling pathway that is common to diverse species and cell types. The mouse, rat, and human COX-2 immediate promoters, despite 7.5 × 107 years of DNA sequence divergence, each retain multiple recognition sites specific for NF-κB-DNA binding. These data suggest that basic gene induction mechanisms, which have been conserved over long periods of evolution, that increase NF-κB-DNA binding may be fundamental in driving transcription from inflammation-related genes, such as COX-2, that operate in stressed tissues, in normally aging cell lines, and in neurodegenerative disorders that include AD brain. J. Neurosci. Res. 53:583–592, 1998. © 1998 Wiley-Liss, Inc.
ChemInform Abstract: WEG ZU TROPONEN AUFGRUND DER 1,3‐DIPOLAREN REAKTIVITAET VON HETEROAROMATISCHEN BETAINEN (1970)

Abstract Das Betain (I) reagiert mit N‐Phenyl‐maleinimid beim Erhitzen in THF zumAddukt (II) (60% Ausbeute) und mit Acrylnitril bzw. Acylsäuremethylesterzu den Verbindungen (III), deren Methojodide bei Behandlung mit Ag‐oxidbzw.
Beamforming Scheme for 2D Displacement Estimation in Ultrasound Imaging (2005)

We propose a beamforming scheme for ultrasound imaging leading to the generation of two sets of images, one with oscillations only in the axial direction and one with oscillations only in the lateral direction. Applied to tissue elasticity imaging, this leads to the development of a specific displacement estimation technique that is capable of accurate estimation of two components of the displacement. The mean standard deviation for the axial displacement estimates is 0.0219 times the wavelength of the axial oscillations , and for the lateral estimates, it is equal to 0.0164 times the wavelength of the lateral oscillations . The method is presented and its feasibility is clearly established by a simulation work.
Abstract TP221: Cerebellar Infarction Presentations: A Population-Based Study From the Greater Cincinnati/Northern Kentucky Stroke Study (2020)

Background: Cerebellar lesions reportedly account for 2-7% of acute infarct visits, but this may be an underestimate since prior studies were not population-based or from the modern imaging era. Cerebellar symptoms are also often nonspecific such that increased MRI use might lead to a higher proportion of stroke due to cerebellar lesions. Details about presenting features of cerebellar infarcts and baseline medication use are also not well known. Methods: We used the 2010 Greater Cincinnati/Northern Kentucky Stroke Study. Strokes were identified by screening ICD9 codes 430-436 and physician verification. Infarct location was categorized as isolated cerebellar, mixed cerebellar (cerebellar plus ≥1 other location), or non-cerebellar. Isolated dizziness was defined as dizziness/vertigo without other focal symptoms. Atherosclerotic cardiovascular disease (ASCVD) 10-year risk scores were calculated. Descriptive statistics and multivariable logistic regression were used to compare infarct categories. Results: Isolated cerebellar lesions occurred in 4.6% (90/1940; 95% CI, 3.7%-5.7%) of infarct events. An additional 4% (77/1940; 95%CI, 3.1%-4.9%) were mixed cerebellar infarcts. Mixed cerebellar infarcts had clinical characteristics more similar to non-cerebellar events than to cerebellar events. The multivariable model found an association of isolated cerebellar infarct with low NIHSS (odds ratio [OR] 2.3, 95% CI 1.1-4.8) and any dizziness/vertigo (OR 5.1, 95% CI, 2.4-10.6), but not with isolated dizziness/vertigo, age, or sex. Median ASCVD scores were high in all infarct categories (21, interquartile range [IQR] 9-35 for isolated cerebellar; 32, IQR 15-42 for mixed cerebellar; 31, IQR 16-52 for all others). Both cerebellar and non-cerebellar strokes had a high frequency of baseline antiplatelet or anticoagulant use (52.1% vs 56.2%), whereas baseline statin therapy was less common in isolated cerebellar infarcts (34.1% vs 43.8%). Conclusions: This population-based study during the modern imaging era found that about 5% of stroke cases have isolated cerebellar infarcts and nearly 9% have any cerebellar infarct. Both cerebellar and non-cerebellar presentations have high baseline vascular risk and antiplatelet/anticoagulant use.
OFC FOREWORD (1985)

Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text I. D. Aggarwal, S. D. Personick, D. Hanson, and S. R. Nagel, "OFC FOREWORD," in Optical Fiber Communication, 1985 OSA Technical Digest Series (Optical Society of America, 1985), paper F1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The Need for Thorough in Vitro Testing of Biomaterial Scaffolds: Two Case Studies (2013)

Tissue engineered scaffolds are an integral part of future regenerative efforts, whether as carriers for stem cells and growth factors, or as acellular supports on their own. These scaffolds will be inserted at the site of injury, aim to provide temporary mechanical support and promote appropriate cell attachment and growth. Millions of dollars are spent on the development of biomaterial scaffolds, with many put into animal studies and clinical use without proper evaluation, often leading to unfavourable outcomes and associated patient morbidity. We exposed two novel scaffolds designed for use in tendon regeneration to a series of in vitro tests, the first a decellularised extracellular matrix (ECM), the second a silk-like material. SEM images were taken to evaluate scaffold nanostructure. Primary human dendritic cells were exposed to scaffolds, with FACS analysis of cell-surface activation markers determining scaffold immunogenicity. Growth of primary tenocytes was analysed using live-dead staining and alamarBlue® fluorescence, for cytocompatability. While, phenotypic retention was assessed through real-time PCR analysis of tenocytic genes. The decellularised ECM demonstrated low activation in the dendritic cell assay, suggesting low immunogenicity. The cytocompatability assays and real-time PCR analyses suggested that the material was indeed suitable for cell growth and differentiation. However, during the third biological repeat, no cells grew on the material, nor did they on the fourth and fifth repeat. In retrospect it appears that following the second repeat a new batch was tested, with very different properties to the first, which accounted for the reduced cytocompatability. The silk-like material produced some of the most repeatable and promising results with the cytocompatability and real-time PCR analyses, while the SEM demonstrated intertwined fibres suitable for cell alignment. However, the immunogenicity assay demonstrated that this material invoked high activation of the primary human dendritic cells, suggesting the material would be unsuitable for in vivo implantation. These studies have highlighted that without stringent testing in vitro, great time and expense would have been spent taking these materials forward for animal studies and potentially clinical studies, when clearly they are not suitable for these in their current incarnation.
Rainfall-Induced Erosion of Biocemented Graded Slopes (2021)

Microbially induced calcite precipitation (MICP), a newly green method, was investigated as a possible solution to rainfall-induced erosion of sandy slopes. A series of model slopes prepared with sands of different gradations were treated by MICP using the surface spraying method. The slopes were subjected to scour under artificial rainfall with an intensity of 700 mm/h. The internal soil loss, the surficial soil loss, the volumes of the internal flow and the surficial flow, and the gradation of the residual soil in the slope model were measured as indicators of the erosion characteristics of the slopes. The results showed that the untreated sandy slopes with a larger uniformity coefficient can be eroded easily while almost no erosion occurred in the untreated ones with a low uniformity coefficient. After MICP treatment, the internal erosion was effectively mitigated for slopes with both large and small uniformity coefficients. In terms of surficial erosion, it was alleviated for the slopes with a larger uniformity coefficient, while intensified for those with low uniformity coefficient, despite the impermeable crusts formed on the slope surface. Therefore, caution must be taken when applying MICP for erosion control of slopes.