gebhart/patrepeval huggingface dataset:
Novel Quinazolin‐4(3H)‐one/Schiff Base Hybrids as Antiproliferative and Phosphodiesterase 4 Inhibitors: Design, Synthesis, and Docking Studies (2014)

A novel series of quinazolin-4(3H)-one/Schiff base hybrids was rationally designed and synthesized. The prepared compounds were evaluated for in vitro activity to inhibit phosphodiesterase 4 (PDE4), where several of them showed good-to-moderate activity compared to rolipram. Compound 7 showed potent PDE4 inhibition in this series, with an IC50 of 1.60 µM. Compounds that showed PDE4 inhibition were further assessed for antiproliferative activity using different human tumor cell lines. Compound 10 exhibited significant antiproliferative activity with IC50 values of 140, 79, and 320 nM in breast, lung, and colon tumor cells, respectively. Docking of compound 7 in the active site of PDE4B illustrates its possible binding mode and provides insight for further optimizations of this novel scaffold for inhibiting PDE4.
Spatially heterogeneous dynamics in thermoset resins below the glass-transition temperature (2000)

A photobleaching technique was used to measure the rotational dynamics of rubrene dispersed in thermoset resins. The matrices were polymerized from mixtures of two monomers with five different compositions. At temperatures below the glass-transition temperature, probe rotational correlation times were shorter and showed a much weaker temperature dependence than those observed in glassy homopolymers. The probe correlation functions became increasingly nonexponential as the amount of the minor component in the matrix increased, presumably because a more heterogeneous set of environments resulted. Dynamics in the single-component sample were quite homogeneous at room temperature. In contrast to homopolymer systems, a bimodal distribution of local relaxation times developed with the addition of the second component. At a given polymer composition, this bimodal distribution changed shape with temperature in a reversible manner. © 2000 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 38: 2232–2239, 2000
A Novel NAND Flash Memory Architecture for Maximally Exploiting Plane-Level Parallelism (2019)

Solid-state drive (SSD) has become one of the most dominant storage devices and is rapidly replacing conventional storage devices. The core component of SSD is NAND flash memory (NFM), where the actual data are stored. Cost pressure is the most critical factor limiting the further deployment of SSDs and past researches have focused on developing cost-effective high-density NFM. Although the cost-driven technology development increases per-chip capacity, it reduces channel-/way-level parallelisms for the given device capacity, resulting in the performance degradation. Such observation directs us to focus on a novel NFM architecture exploiting plane-level parallelism. The distinct features of this architecture are: 1) enabling a decoupled word-line (WL) selection for the mated planes and 2) segmenting each plane into subplanes for further maximizing the plane-level parallelism. The experimental results show that decoupled WL selection improves the throughput by up to 21.3% with a marginal overhead of less than 1%, compared to the conventional NFM architecture. In addition, adopting the plane segmentation improves the throughput by up to 43.9% with an additional overhead of 14%. Considering the tradeoff between performance and overhead, the proposed NFM architecture is a cost-efficient method to secure high performance under decreasing channel-/way-level parallelisms in high-density NFM.
Solubility study of polyacrylamide in polar solvents (2004)

Abstract Contact angles and surface tension data were measured to obtain the surface tension components of polyacrylamide (PAM). According to Van Oss, Chaudhury, and Good (VCG) theory, the surface tension components were used to calculate the PAM solubility in five different polar solvents: water, ethylene glycol (EG), acetone, ethanol, and dimethyl formamide (DMF). It was found that PAM had a monopolar surface nature, which resulted in polymer dissolution in water. The solubility of PAM in water was greater than in EG, but PAM was solvophobic in the other three solvents. For PAM, water, and the second solvent (cosolvent) ternary system, the solubility of PAM could not be calculated directly. Surface tension was used as an index of polarity for cosolvent systems (the mixture of water and the second solvent). The cosolvent polarity decreased when the composition of the second solvent increased. PAM would be dissolved in the cosolvent when the system's polar contribution was greater than the apolar contribution. The apparent surface tension of PAM aqueous solutions was not sensitive enough to show polymer conformation changes when additive concentrations were changed. The solubility of PAM in binary polar solvent systems or ternary cosolvent systems was used to estimating the swelling properties of a PAM hydrogel under corresponding external conditions. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 93: 1493–1499, 2004
Pulsatile Flow Regulates Monocyte Adhesion to Oxidized Lipid-Induced Endothelial Cells (2001)

Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (ox-PAPC), a component of minimally modified low density lipoprotein, induces monocyte adhesion to endothelial cells. It is not known whether the upstroke slopes of pulsatile flow, defined as shear stress slew rates (tau(r)/tauT)), can regulate monocyte binding to ox-PAPC-treated bovine aortic endothelial cells (BAECs). At 60 cycles per minute, ox-PAPC-treated BAECs were exposed to 3 conditions representing known vascular conditions: (1) high shear stress slew rates (tau(r)/tau(T)=293 dyne. cm(-2). s(-1)), with time-averaged shear stress=50 dyne/cm(2); (2) low shear stress slew rate (tau(r)/tau(t)=71 dyne. cm(-2). s(-1)), with identical time-averaged shear stress; and (3) reversing oscillating flow (0+/-2.6 mm Hg). Reverse transcription-polymerase chain reaction and quantification were performed for monocyte chemoattractant protein-1 (MCP-1) mRNA expression. High tau(r)/tau(t) reduced monocyte binding to ox-PAPC-treated BAECs by 64+/-3.2% compared with static conditions, and low tau(r)/tau(t) reduced monocyte binding by 31+/-3.4%, whereas oscillating flow increased monocyte binding by 22+/-1.7% (P<0.005). High partial tau(r)/tau(t) downregulated MCP-1 expression by 33+/-8%, and low partial tau(r)/tau(t) downregulated MCP-1 expression by 15+/-4%, but oscillating flow upregulated MCP-1 by 13+/-5%. These results suggest that shear stress slew rates regulate monocyte binding by modulating the expression of a potent monocyte chemoattractant.
Spectral Evidence for Through the Ring Coupling of the Nitrogen Inversion and Methyl Torsion in p- Methylaniline (1990)

Two peaks in the p-methylanilne fluorescence excitation spectrum show an unusual splitting that is not evident in the other vibrational bands, or in the aniline spectrum. These bands both display a large deuterum shift $(-200 cm^{-1})$ in the $ND_{2}$ molecule and are thus attributed to the inversion and torsion of the amine group. The presence of the splittings in the amine modes in p-methylanllne, coupled with its absence in the bare aniline suggests that the methyl torsion may be coupled to the mine motion at the opposite end of the ring. Supporting evidence for this interpretation will be presented.
A 1.23W/mm2 83.7%-Efficiency 400MHz 6-Phase Fully Integrated Buck Converter in 28nm CMOS with On-Chip Capacitor Dynamic Re-Allocation for Inter-Inductor Current Balancing and Fast DVS of 75mV/ns (2022)

For more efficient power management in processors, a high-frequency and multi-phase (MP) integrated voltage regulator (IVR) using multiple inductors would be an ideal solution to deliver optimized power with rapid dynamic voltage scaling (DVS) [1]–[5]. Nevertheless, in practical use, MP-IVRs suffer from an inter-inductor current imbalance because of mismatches in integrated inductances, different parasitic resistances, and duty-control skews among all phases (top of Fig. 18.1.1). Such a current mismatch may cause larger output ripple and efficiency degradation, losing the benefits of multi-phase operation. Also, thermal hotspots can occur due to excessive current density and deteriorate reliability. Previous approaches [2], [4] use current sensors to calibrate the duty cycle of each phase, but the design complexity and power overhead tend to be greatly increased in the high-speed sensing circuitry for fast-switching converters. An additional consideration in MP-IVRs is the phase-shedding technique, which can improve the light-load efficiency by reducing the number of phases. In many prior works [1], [2], the number of phases was adjusted by 2N (e.g., 1-2-4) for simplicity of phase division. If the phase-shedding is more fine-grained, the overall efficiency can be more flattened over a wide range of loads. Moreover, because the frequency response and output ripple vary according to the number of phases, the MP-IVR should be adaptively optimized further for them. This paper presents a 400MHz 6-phase fully integrated buck converter (bottom of Fig. 18.1.1). Key contributions of this work include 1) inter-inductor true-average-current matching by the flying-capacitor-based peak-and-valley differential sensing (PVDS) technique with near-zero power overhead, 2) area-efficient dynamic re-allocation of on-chip capacitors used either in the PVDS or at the output for optimizing responsiveness and voltage ripple adaptively to the number of phases, and 3) DLL -based multi-phase clock generation (MPCG) for fine-grained phase-shedding functionality, improving efficiency over a wide load range.
Publisher's Note: Gated-charge force microscopy for imaging a surface-acoustic-wave-induced charge in a depleted one-dimensional channel [Phys. Rev. B78, 125330 (2008)] (2008)

Received 14 October 2008DOI:https://doi.org/10.1103/PhysRevB.78.159903©2008 American Physical Society
“Functional Food” for Acceleration of Growth in Short Children Born Small for Gestational Age (2010)

Six months of vitamin A, iron and zinc supplementation induces growth acceleration in short children born SGA with subnormal nutrients intake similar to growth hormone therapy.
Prendre soin des soignants : la difficile construction d'une prise en charge psychologique du personnel soignant (2010)

Le cadre En règle générale, en France, il apparaît extrêmement délicat de faire reconnaître aux directeurs hospitaliers combien le soutien psychologique du personnel médical peut être bénéfique pour leurs pratiques thérapeutiques. Dans la plupart des institutions il ne se dégage pas de volonté de s'inquiéter du personnel soignant. La plupart des administrateurs hospitaliers hésitent à envoyer leur personnel dans des groupes de travail à moins qu'ils n'aient l'assurance « qu'il apprendra quelq...
The generated order preserving real-time garbage collection (2002)

This paper proposes a new real-time garbage collection that always preserves the order of object creation. Some programming languages and application programs need to preserve the generated order of objects. The proposed method is the first type of the garbage collection that can be used to make them run in real-time. Since the generated order preserving scavenging garbage collection is partly employed, the complexity of the proposed method is not related to the heap size. The requirements for the real-time processing is also presented.
Diet: Cause or Consequence of the Microbial Profile of Cholelithiasis Disease? (2018)

Recent dietary habits and lifestyle could explain the shaping of the gut microbiota composition and, in consequence, the increasing prevalence of certain pathologies. However, little attention has been paid to the influence of diet on microbiotas, other than the gut microbiota. This is important in cholelithiasis, given that changes in the production of bile acids may affect gallbladder microbial communities. Our aim was to assess the association between regular dietary intake and gallbladder microbial composition. Fourteen adults with cholelithiasis and 14 controls, sex‒age-matched and without gastrointestinal pathology, were included. Diet was assessed through a food frequency questionnaire and quantification of gallbladder microbiota sequences by Illumina 16S rRNA gene-based analysis. The cholelithiasic patients showed greater intake of potatoes and lower consumption of vegetables, non-alcoholic drinks, and sauces, which resulted in a lower intake of energy, lipids, digestible polysaccharides, folate, calcium, magnesium, vitamin C, and some phenolic compounds. Regarding the altered bile microorganisms in cholelithiasic patients, dairy product intake was negatively associated with the proportions of <i>Bacteroidaceae</i> and <i>Bacteroides,</i> and several types of fiber, phenolics, and fatty acids were linked to the abundance of <i>Bacteroidaceae</i>, <i>Chitinophagaceae</i>, <i>Propionibacteraceae</i>, <i>Bacteroides</i>, and <i>Escherichia‒Shigella</i>. These results support a link between diet, biliary microbiota, and cholelithiasis.
Electrode material comprising graphene-composite materials in a graphite network (2023)

A durable electrode material suitable for use in Li ion batteries is provided. The material is comprised of a continuous network of graphite regions integrated with, and in good electrical contact with a composite comprising graphene sheets and an electrically active material, such as silicon, wherein the electrically active material is dispersed between, and supported by, the graphene sheets.
TFEB-mTORC1 feedback loop in metabolism and cancer (2017)

TFEB-mTORC1 feedback loop in metabolism and cancer – Everyday most organisms face the requirement to adapt their metabolic cues to the fluctuation of nutrient resources into the environment. When nutrients are abundant cells activate anabolic pathways, such as protein and lipid synthesis, and promote cell proliferation and growth. On the contrary, when food availability is scarce or even absent, cells shut off anabolism (...)
PD60 What Are The Opportunities And Challenges To Implementing Value Based Healthcare Pilots In The Brazilian Private Healthcare System? (2022)

Introduction The Brazilian National Agency for private healthcare system (ANS) regulates the private healthcare system in Brazil. ANS, since 2019, has been running the pilot value-based new payment models project. In total, 13 projects were selected by ANS. This investigation aims to identify opportunities and challenges to implement value based healthcare (VBHC) in Brazil. Methods We interviewed managers participating in the ANS’ Value-Based Payment Models. Data were collected through semi-structured interviews during 2021. Twelve managers were invited to participate in the interview and eight accepted the invitation. The key questions were: “what are the main factors that facilitate – or limit - the transition from the fee for service model to a value-based model in the private healthcare system? And “will the payment models be scalable?” For data analysis, Bardin’s content analysis was chosen. Data validation was performed using the debriefings technique. Results The interviews identified two key facilitating factors: people (identified by 50% of respondents) and processes (identified by 50% of respondents). Reponses relating to people nominated the need for professionals with VBHC knowledge (33%), support of senior management (25%), support from the provider (25%) and care team (17%). Reponses relating to processes nominated the need for partnership (58%), health-driven management (25%) and results (17%). We also identified that limiting factors (49%) were: providers (39%), in details: non-support from the provider, (56%), fear of financial loss (22%) and provider only wanting profit (22%); information system (30%), with data management; culture (17%), current versus innovative models; and peoples (13%), knowledge. More than 90 percent found it to be scalable, particularly, in vertical health plans (38%), large operators (38%); and provide diagnostic services (13%). We found that non-scalable situations are those where fee for service is hegemonic in terms of payments. Conclusions Our study found that knowledge and culture management positively impacts the projects. Service providers can be limiting when they are exclusively focused on economic perspectives. The new payment model is considered scalable.
Topological polarons, quasiparticle invariants, and their detection in one-dimensional symmetry-protected phases (2019)

In the presence of symmetries, one-dimensional quantum systems can exhibit topological order, which in many cases can be characterized by a quantized value of the many-body geometric Zak or Berry phase. We establish that this topological Zak phase is directly related to the Zak phase of an elementary quasiparticle excitation in the system. By considering various systems, we establish this connection for a number of different interacting phases including the Su-Schrieffer-Heeger model, $p$-wave topological superconductors, and the Haldane chain. Crucially, in contrast to the bulk many-body Zak phase associated with the ground state of such systems, the topological invariant associated with quasiparticle excitations (above this ground state) exhibits a more natural route for direct experimental detection. To this end, we build upon recent work [F. Grusdt, et al., Nat. Commun. 7, 11994 (2016)] and demonstrate that mobile quantum impurities can be used, in combination with Ramsey interferometry and Bloch oscillations, to directly measure these quasiparticle topological invariants. Finally, a concrete experimental realization of our protocol for dimerized Mott insulators in ultracold atomic systems is discussed and analyzed.
The Origin of Lipid Rafts (2020)

The time-averaged lateral organization of the lipids and proteins that make up mammalian cell membranes continues to be the subject of intense interest and debate. Since the introduction of the fluid mosaic model almost 50 years ago, the "lipid raft hypothesis" has emerged as a popular concept that has captured the imagination of a large segment of the biomembrane community. In particular, the notion that lipid rafts play a pivotal role in cellular processes such as signal transduction and membrane protein trafficking is now favored by many investigators. Despite the attractiveness of lipid rafts, their composition, size, lifetime, biological function, and even the very existence remain controversial. The central tenet that underlies this hypothesis is that cholesterol and high-melting lipids have favorable interactions (i.e., they pull together), which lead to transient domains. Recent nearest-neighbor recognition (NNR) studies have expanded the lipid raft hypothesis to include the influence that low-melting lipids have on the organization of lipid membranes. Specifically, it has been found that mimics of cholesterol and high-melting lipids are repelled (i.e., pushed away) by low-melting lipids in fluid bilayers. The picture that has emerged from our NNR studies is that lipid mixing is governed by a balance of these "push and pull" forces, which maximizes the number of hydrocarbon contacts and attractive van der Waals interactions within the membrane. The power of the NNR methodology is that it allows one to probe these push/pull interaction energies that are measured in tens of calories per mole.
Intraocular Lens Glucose Sensor (2000)

Ocular spectroscopy, which is the use of the eye to monitor optically the concentration of metabolites in the body, has been successfully applied to monitor aqueous humor glucose concentration. In the United States, 1.7 million intraocular lenses are currently implanted yearly. Because patients with diabetes are more likely to develop cataracts at an earlier age, a relatively high proportion of the patients receiving intraocular lenses have diabetes. Last year, 110,000 patients with diabetes received intraocular lens implants of various materials. We have successfully polymerized a fluorescent complex within a hydrogel intraocular lens that responds well to glucose concentration.
A Bayesian approach to image expansion for improved definition (1994)

Accurate image expansion is important in many areas of image analysis. Common methods of expansion, such as linear and spline techniques, tend to smooth the image data at edge regions. This paper introduces a method for nonlinear image expansion which preserves the discontinuities of the original image, producing an expanded image with improved definition. The maximum a posteriori (MAP) estimation techniques that are proposed for noise-free and noisy images result in the optimization of convex functionals. The expanded images produced from these methods will be shown to be aesthetically and quantitatively superior to images expanded by the standard methods of replication, linear interpolation, and cubic B-spline expansion.
API recommendation for Mashup creation based on neural graph collaborative filtering (2021)

With the increase of open APIs appeared on the Web, reusing or combining these APIs to develop novel applications (e.g. Mashups) has attracted great interest from developers. However, to quickly find a suitable one among a huge number of APIs to meet a developer’s requirement is basically a non-trivial issue. Therefore, a high-quality API recommendation system is desirable. Although a number of collaborative filtering methods have been proposed for API recommendation, their recommendation accuracy is limited and needs to be further improved. Based on the neural graph collaborative filtering technique, this paper proposes an API recommendation method that exploits the high-order connectivity between APIs and API users. To evaluate the proposed method, extensive experiments are conducted on a real API dataset and the results show that the proposed method outperforms the state-of-the-art methods in API recommendation.
Two-Dimensional Structural Motif in Thienoacene Semiconductors: Synthesis, Structure, and Properties of Tetrathienoanthracene Isomers (2008)

Stille coupling of 2- and 3-(tributylstannyl)thiophene derivatives with tetrabromobenzene followed by oxidative cyclization provides a simple, two-step synthetic route to two isomeric tetrathienoanthracene structures (13 and 14). The materials are characterized by a remarkable thermal stability, both in air (Tdec ≈ 400 °C) and under nitrogen (sublimed with no decomposition at 450–500 °C). Optical studies of the parent and alkylated compounds showed sky-blue photoluminescence with quantum yields ranging between 0.17 and 0.40 and Stokes shifts of 0.03–0.16 eV. Both the optical properties and electrochemical behavior depend strongly on the position of the heteroatoms. Structural studies with X-ray crystallography (for 3D single crystals) and scanning tunneling microscopy (for 2D monolayers) indicate a high level of order, with similar intermolecular interactions for both isomers. The alkylated materials 13b and 14b have been used to fabricate thin-film transistors by both vacuum evaporation and solution processing. The preliminary studies show (unoptimized) hole mobilities of up to 7.4 × 10−2 cm2 V−1 s−1 and very high on/off ratios of up to 1 × 108 for vacuum-deposited films. The isomer 13, which showed higher thermodynamic stability of the radical cation and stronger intermolecular S···S contacts, also revealed better device performance.