gebhart/patrepeval huggingface dataset:
The antielectrostatic properties of quaternary imidazolium chlorides (1987)

Abstract The antielectrostatic properties of quaternary imidazolium chlorides deposited on low density polyethylene films were studied. The experiments point out that these chlorides possess certain antielectrostatic properties since they diminish the surface resistance by about two orders of magnitude, and the half decay time achieves values below 100 s. The antielectrostatic effect depends on the length of the radical in the positions one and three.
La mediación como cauce de resolución de conflictos jurídicos en el derecho español y comparado: bases para el desarrollo de la cultura de la mediación (2015)

La presente investigacion intenta afrontar el papel de la mediacion en el modelo social espanol particularmente y en su cultura juridica a traves del estudio de las bases teoricas y su praxis operativa desde una perspectiva transdisciplinar. Una realidad juridica que demanda la necesidad de introducir profundas reformas en el ambito de la justicia ante el colapso administrativo y burocratico de los procesos judiciales. La crisis del actual sistema judicial reclama una evolucion hacia un cambio de paradigma legal que propicie la progresiva desjudicializacion del conflicto en la que los sistemas multiproceso se presentan como la mejor alternativa para superar la cultura adversarial, en donde la mediacion, debe formar parte de un sistema de justicia mas integral. Por ello esta tesis doctoral propone establecer las bases viables del paradigma mediador y proponer medidas efectivas tales como: la necesidad de la presencia de los operadores juridicos en todos sus ambitos para dotar de mayor eficacia el ejercicio de la justicia; la asistencia e informacion necesaria desde las plataformas institucionales que para ello deben crearse; la exigencia de una formacion solida y rigurosa de los futuros mediadores; y la sensibilizacion hacia una cultura mediadora fomentada a traves del sistema educativo.
Synthetic peptides corresponding to the calmodulin-binding domains of skeletal muscle myosin light chain kinase and human erythrocyte calcium pump interact with and permeabilize liposomes and cell membranes (1993)

Synthetic calmodulin-binding (CaM-binding) peptides (CBPs) representing CaM-binding domains of Ca2+/CaM-dependent enzymes have been reported to interfere with the activity of the melanocyte-stimulating hormone (MSH) receptor function in melanoma cells [Gerst, J. E., & Salomon, Y. (1988) J. Biol. Chem. 263, 7073-7078]. We postulated that membrane lipids may play an important role in the mode of action of CBPs on cells. We therefore tested the ability of CBPs to interact with membrane bilayers. Using artificial phospholipid vesicles, or M2R melanoma cells and cell membranes derived therefrom, as models, we report here that synthetic peptides representing the CaM-binding domains of skeletal muscle myosin light chain kinase (M5) and the human erythrocyte calcium pump (C28W), as well as other CBPs, interact with lipid bilayers and cell membranes. Significant interactions of CBPs with the lipid bilayer were detected in both model systems. M5 and C28W were found to partition into the lipid bilayer of melanoma cell membranes and soybean lecithin vesicles, and surface partition constants obtained (for the liposome model) were in the range 10(3)-10(4) M-1. In addition, C28W and its N-modified NBD derivative were found to inhibit [125I]iodo-[Nle4,D-Phe7]alpha MSH binding to cultured M2R melanoma cells. These and other CBPs were also found to induce the release of cations and calcein from liposomes, suggesting that the interaction of CBPs with the lipid bilayer increases membrane permeability.(ABSTRACT TRUNCATED AT 250 WORDS)
Equivalent lightness of colored objects at illuminances from the scotopic to the photopic level (1989)

Abstract Equivalent lightness of four colored objects, blue, green, yellow, and red, was obtained for illuminance levels covering the range 0.01 to 1000 lx by brightness matching to a grey scale. Three field sizes, 20', 1° and 6° arc of visual angle, were investigated. With the smallest size, for which no rod response was expected, the equivalent lightness increased monotonically for incresing illuminance, showing the increasing effect of colorfulness upon brightness. The results obtained with the largest size showed influence from both rods and cones and were interpreted as due to two underlying lightnesses, one lightness based on the achromatic response of rods, cones, or both, and the other lightness based on the chromatic response of cones exhibited as colorfulness.
Correcting Highly Aberrated Eyes Using Large-stroke Adaptive Optics (2007)

Aberrations in both normal and highly aberrated eyes were successfully corrected using the large-stroke deformable mirror to provide almost perfect optical quality. This mirror can be a powerful tool to assess the limit of visual performance achievable after correcting the aberrations, especially in eyes with abnormal corneal profiles.
Optimization of categorizing driver's head motion for driving assistance systems (2012)

Many car accidents are caused by driver's deviation from normal condition like carelessness. We aim to construct a driving assist system that is able to detect driver's deviation signal from normal condition. The system detects the deviation signal using driver's time-series head motion information. In this paper, we optimize categorization of driver's head motion using two kinds of unsupervised neural networks: Self-Organizing Maps and Fuzzy Adaptive Resonance Theory, and discuss the relation between vigilance parameter and integrated categories.
Peer-to-peer adaptive video streaming system (2015)

The paper presents a peer-to-peer video streaming system with an ability to change the encoded video resolution adaptively to the data throughput changes. The low latency live video streaming based on the WebRTC specification was used in the investigation. The P2P video streaming system was able to predict the current performance of the data connection in the receiver and react by sending a request to the sender to increase or decrease the video resolution. An experimental investigation was performed by the use of network emulator and activating the 10% packet loss emulation. The system proposed in this paper was able to decrease the video resolution when the packet loss rate was increased. In addition, the system was able to detect the increase of the data throughput and to return the high video resolution for the video stream.
mi RNA: Licensed to Kill the Messenger (2007)

Current developments have brought non-coding genes under limelight together with their better-known siblings, the coding genes or mRNA. The 2006 Nobel Prize in Physiology or Medicine was awarded to Andrew Fire and Craig Mello for their 1998 discovery that double-stranded RNA triggers suppression of gene activity in a homology-dependent manner, a process named RNA interference (RNAi). Post-transcriptional regulation of genes was generally regarded as an odd regulatory mechanism for several years until it was learnt that regulatory trans-acting antisense RNAs exist in several species. Identification of a large number of small RNA molecules called microRNAs (miRNAs) elevated the overall field of biomedical RNAi to the striking level of current recognition. miRNAs represent a class of endogenous small ( approximately 22 nucleotides) RNA molecules that can repress protein synthesis. It is estimated that there are over 600 miRNAs in mammalian cells, and that about 30% of all genes are regulated by miRNA. Current understanding of the molecular mechanism of any disease would be incomplete without factoring in the functional significance of miRNA. In the category of the futuristic RNAi drugs, miRNA-based therapies are promising. The field has progressed rapidly as it relates to cancer research (highlighted in DNA and Cell Biology Volume 26, Number 4), while development in most other areas (highlighted in DNA and Cell Biology Volume 26, Number 3) of biomedical research remains in its infancy, offering significant opportunity for researchers. Approaches to interfere with miRNA function in vivo offer novel therapeutic opportunities. Lessons in gene therapy have taught us that tinkering with the genetic machinery comes with its own set of risks, especially in a clinical setting. miRNA-based therapies are also subject to such risks, which need to be prudently managed. Having acknowledged the potential risk, we have to recognize that new knowledge about the functional roles of miRNA is revolutionizing cell biology and will have a major impact on biomedical research imminently.
Effect of external stress on discontinuous precipitation on {100} planes in Cu–5.7 wt% Ag single crystals (2005)

The application of external stress during ageing induces the oriented formation of disc-shaped aggregates consisting of rod-shaped Ag precipitates and a Cu matrix on {100} planes in single crystals of a Cu–5.7 wt% Ag alloy. Tensile stress along the [001] axis induces preferential formation of the aggregates perpendicular to the [001] axis and compressive stress induces the same parallel to the stress axis. The stress-orienting effect is determined during the initial stage of precipitation, when the formation of the aggregates starts on dislocations. The experimental result can be understood if the misfit strain of the aggregates in a direction perpendicular to the disc plane is larger than that in the parallel direction. This idea is supported by length-change measurements during ageing.
Interfacial characterization of Al-Al thermocompression bonds (2016)

Interfaces formed by Al-Al thermocompression bonding were studied by the transmission electron microscopy. Si wafer pairs having patterned bonding frames were bonded using Al films deposited on Si or SiO2 as intermediate bonding media. A bond force of 36 or 60 kN at bonding temperatures ranging from 400–550 °C was applied for a duration of 60 min. Differences in the bonded interfaces of 200 μm wide sealing frames were investigated. It was observed that the interface had voids for bonding with 36 kN at 400 °C for Al deposited both on Si and on SiO2. However, the dicing yield was 33% for Al on Si and 98% for Al on SiO2, attesting for the higher quality of the latter bonds. Both a bond force of 60 kN applied at 400 °C and a bond force of 36 kN applied at 550 °C resulted in completely bonded frames with dicing yields of, respectively, 100% and 96%. A high density of long dislocations in the Al grains was observed for the 60 kN case, while the higher temperature resulted in grain boundary rotation away from the original Al-Al interface towards more stable configurations. Possible bonding mechanisms and reasons for the large difference in bonding quality of the Al films deposited on Si or SiO2 are discussed.
An active power filter using single-phase NPC converters and predictive control for medium voltage distribution systems (2013)

An active power filter implemented with three single-phase Neutral Point Clamped (NPC) converters is presented and analyzed. The proposed active power filter is aimed to compensate current harmonics and reactive power in three-phase medium voltage power distribution systems. A predictive control algorithm provides the switching states that ensure fast current tracking capability. To take advantage of the predictive control implementation simplicity, this paper includes useful information to replicate this implementation on similar topologies of multilevel converters. The proposed scheme presents lower line to line voltage harmonic distortion as well as an independent control in each phase, compared with the conventional three-phase NPC topology. Simulated results confirm the implementation viability of the proposed active power filter topology and associated control strategy.
Cis-jasmone As Semiochemical (Patent CA 2388964 C) (2009)

cis-Jasmone has been discovered to be useful as a semiochemical that changes the behaviour of insects and/or the physiology of plants. It has direct signalling roles with plant-feeding aphids, in attraction of aphid predators and parasitoids, and may act as an airborne signal inducing production of volatile plant semiochemicals, including the monoterpene (E)-.beta.-ocimene. that stimulate foraging by parasitoids. It is an extremely benign compound having , to human beings, a pleasant aroma and gives a long-lasting effect after removal of the stimulus.
Ivosidenib in relapsed or refractory acute myeloid leukemia: a profile of its use in the USA (2019)

Ivosidenib (Tibsovo®), a first-in-class, small molecule inhibitor of mutant isocitrate dehydrogenase 1 (IDH1), is an important new therapeutic option in the USA for treating adults with relapsed or refractory acute myeloid leukemia who have a susceptible IDH1 gene mutation. In such patients, oral ivosidenib is effective and generally well tolerated, producing encouraging rates and durations of complete remission (CR), CR or CR with partial hematologic recovery (CR/CRh), overall response, and overall survival. CR/CRh rates are consistent across most baseline characteristics. Ivosidenib also provides additional clinical benefits, including transfusion independence, improvements in hematologic variables, and deep molecular responses as measured by IDH1 mutation clearance in patients who achieve CR/CRh.
Automatic detection of pole-like structures in 3D urban environments (2014)

This work aims at automatic detection of man-made pole-like structures in scans of urban environments acquired by a 3D sensor mounted on top a moving vehicle. Pole-like structures, such as e.g. road signs and streetlights, are widespread in these environments, and their reliable detection is relevant to applications dealing with autonomous navigation, facility damage detection, city planning and maintenance. Yet, due to the characteristic thin shape, detection of man-made pole-like structures is significantly prone to both noise as well as occlusions and clutter, the latter being pervasive nuisances when scanning urban environments. Our approach is based on a “local” stage, whereby local features are classified and clustered together, followed by a “global” stage aimed at further classification of candidate entities. The proposed pipeline turns out effective in experiments on a standard publicly available dataset as well as on a challenging dataset acquired during the project for validation purposes.
Conception d'un robot parallèle rapide à 4 degrés de liberté (1991)

These Ecole polytechnique federale de Lausanne EPFL, n° 925 (1991)Laboratoire de systemes robotiques 2 Reference doi:10.5075/epfl-thesis-925Print copy in library catalog Record created on 2005-03-16, modified on 2017-05-10
Real‐value representation in inversion‐recovery NMR imaging by use of a phase‐correction method (1986)

A new technique of real-value representation in inversion-recovery (IR) imaging by use of a phase-correction method is proposed. In this scheme, negative magnetizations at the beginning of the inversion point (T1 approximately equal to 0) are correctly represented as negative values rather than positive. By use of this new scheme, a consistent IR image set as a function of several inversion times (T1) can be obtained. The latter, i.e., consistent image set which represents the real value of T1 weighted images at several inversion times is important in the search for tumors and abnormalities since the inversion time (T1) in the pulse sequence strongly affects T1 contrast.
Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites (2006)

These data suggest radiation of genes encoding remodeling and virulence factors from a small number of loci in a common Plasmodium ancestor, and imply a closer phylogenetic relationship between the P. vivax and P. falciparum lineages than previously believed. The presence of a conserved 'exportome' in the genus Plasmodium has important implications for our understanding of both common mechanisms and species-specific differences in host-parasite interactions, and may be crucial in developing novel antimalarial drugs to this infectious disease.
Toughening behavior of polyamide‐rubber blends (1990)

Abstract The impact behavior of nylon 6‐ rubber blends is studied by varying the rubber concentration (0–26 vol. %), rubber particle size (0.1 ‐ 2.0 μm) and rubber properties. The brittle to tough transition shifts to lower temperatures by increasing the rubber concentration, decreasing the particle size and by lowering the modulus of the elastomer. With very small particle sizes, however, the transition temperature increases again. The toughness of the blends above their transition temperature increases with the rubber concentration, but the particle size has only some effect. Very small particle sizes decrease the impact behavior. The postulated deformation mechanism is cavitation of the rubber followed by shear deformation of the matrix.
Small Molecules ATP-Competitive Inhibitors of FLT3: A Chemical Overview (2008)

FLT3 is a tyrosine kinase (TK), member of the class III TK receptor family, normally expressed in hematopoietic, immune and neural systems, also playing an important role in the pathogenesis of acute leukemias, particularly acute myeloid leukemia (AML), where it is present in constitutively activated mutated forms, correlated with poor prognosis, in a notable percentage of patients. For these reasons FLT3 soon appeared as a promising target for the therapeutic intervention for this severe and aggressive malignancy; the recent determination of the crystal structure of the autoinhibited form of FLT3 gave new trend for the design and the synthesis of potent inhibitors. Small molecules tyrosine kinase inhibitors represent one of the largest drug family currently targeted by pharmaceutical companies for the treatment of cancer. Exciting examples of such molecules have reached advanced clinical trials and have been recently approved by FDA for the treatment of different solid or haematological tumors. Usually TK inhibitors share common features, namely two hydrophobic/aromatic regions bearing one or more hydrogen bonding substituents. These two regions can be connected by different spacers and almost all the molecules contain a component resembling the ATP purine structure. This review will deal with FLT3 synthetic inhibitors, reporting not only the most important molecules that are in clinical trials, but also the new compounds that have appeared in literature in the last few years. Our attention will be focused on chemical structures, mechanisms of action and structure-activity relationships.
Noisy Speech Recognition Based on Integration/Selection of Multiple Noise Suppression Methods Using Noise GMMs (2008)

To achieve high recognition performance for a wide variety of noise and for a wide range of signal-to-noise ratio, this paper presents methods for integration of four noise reduction algorithms: spectral subtraction with smoothing of time direction, temporal domain SVD-based speech enhancement, GMM-based speech estimation and KLT-based comb-filtering. In this paper, we proposed two types of combination methods of noise suppression algorithms: selection of front-end processor and combination of results from multiple recognition processes. Recognition results on the CENSREC-1 task showed the effectiveness of our proposed methods.kn-abstract=
γδT Cells: First Line of Defense and Beyond (2014)

γδ T cells, αβ T cells, and B cells are present together in all but the most primitive vertebrates, suggesting that each population contributes to host immune competence uniquely and that all three are necessary for maintaining immune competence. Functional and molecular analyses indicate that in infections, γδ T cells respond earlier than αβ T cells do and that they emerge late after pathogen numbers start to decline. Thus, these cells may be involved in both establishing and regulating the inflammatory response. Moreover, γδ T cells and αβ T cells are clearly distinct in their antigen recognition and activation requirements as well as in the development of their antigen-specific repertoire and effector function. These aspects allow γδ T cells to occupy unique temporal and functional niches in host immune defense. We review these and other advances in γδ T cell biology in the context of their being the major initial IL-17 producers in acute infection.
Automated Particle Picking Based On Correlation Peak Shape Analysis And Iterative Classification (2012)

Cryo-electron microscopy (CEM) in combination with single particle analysis (SPA) is a widely used technique for elucidating structural details of macromolecular assemblies at closeto- atomic resolutions. However, development of automated software for SPA processing is still vital since thousands to millions of individual particle images need to be processed. Here, we present our workflow for automated particle picking. Our approach integrates peak shape analysis to the classical correlation and an iterative approach to separate macromolecules and background by classification. This particle selection workflow furthermore provides a robust means for SPA with little user interaction. Processing simulated and experimental data assesses performance of the presented tools.
Resonance Raman characterization of H(M200)L mutant reaction centers from Rhodobacter capsulatus. Effects of heterodimer formation on the structural and electronic properties of the bacteriochlorin cofactors (1995)

Resonance Raman (RR) spectra are reported for photosynthetic reactions centers (RCs) from the H(M200)L mutant of Rhodobacter capsulatus. In this mutant, the histidine residue which ligates the M-side bacteriochlorophyll (BCh) of the special pair primary donor (P) of wild-type RCs is replaced by a noncoordinating leucine. This results in the formation of a heterodimer primary donor (D) in which a bacteriopheophytin (BPh) replaces the M-side BCh. The RR data for the H(M200)L mutant were acquired at a large number of excitation wavelengths which span the B, Qx, and Qy absorption bands of the various bacteriochlorin cofactors in the RC. For comparison, spectra were also acquired for wild-type RCs at the same excitation wavelengths. The RR data obtained for the mutant indicate that heterodimer formation induces a variety of changes in the structural and electronic properties of the cofactors in the RC. These perturbations extend beyond the primary donor and include one of the two accessory BChs. Collectively, the RR studies indicate the following: (1) The structure of the single BCh cofactor in D [DL(BCh)] is different from that of either of the two BChs in P. However, DL(BCh) is more similar to PL than to PM. The PM cofactor is conformationally more distorted than either PL or DL(BCh). (2) The structure of the BPh cofactor in D [DM(BPh)] is similar to that of the other two BPhs in the RC. However, the frequency of the C9-keto carbonyl mode of DM(BPh) is anomalously low (1678 cm-1), as is also the case for PM. The vibrational characteristics of the C9-keto carbonyl vibrations of DM(BPh)/PM versus DL(BCh)/PL are consistent the notion that dielectric effects govern the frequency of the mode and that the effective dielectric constant is different on the L- versus M-sides of the primary donor. (3) Heterodimer formation perturbs the structural and electronic properties of one of the two accessory BChs (most likely BChL) in the RC. These perturbations are manifested as upshifts in the ring skeletal-mode frequencies and a blue-shift in the Qx absorption band (from 600 to 580 nm). The fact that heterodimer formation perturbs one of the accessory BChs suggests that global structural rearrangements occur in the protein matrix when the ligand to a cofactor in the primary donor is removed. (4) For both the H(M200)L mutant and wild-type RCs, oxidation of the primary donor significantly affects the RR cross section of the carotenoid.(ABSTRACT TRUNCATED AT 400 WORDS)