gebhart/patrepeval huggingface dataset:
Data from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase (2023)

&lt;div&gt;Abstract&lt;p&gt;Proteins that communicate signals from the cytoskeleton to the nucleus are prime targets for effectors of metastasis as they often transduce signals regulating adhesion, motility, and invasiveness. LIM domain proteins shuttle between the cytoplasm and the nucleus, and bind to partners in both compartments, often coupling changes in gene expression to extracellular cues. In this work, we characterize LIMD2, a mechanistically undefined LIM-only protein originally found to be overexpressed in metastatic lesions but absent in the matched primary tumor. LIMD2 levels in fresh and archival tumors positively correlate with cell motility, metastatic potential, and grade, including bladder, melanoma, breast, and thyroid tumors. LIMD2 directly contributes to these cellular phenotypes as shown by overexpression, knockdown, and reconstitution experiments in cell culture models. The solution structure of LIMD2 that was determined using nuclear magnetic resonance revealed a classic LIM-domain structure that was highly related to LIM1 of PINCH1, a core component of the integrin-linked kinase–parvin–pinch complex. Structural and biochemical analyses revealed that LIMD2 bound directly to the kinase domain of integrin-linked kinase (ILK) near the active site and strongly activated ILK kinase activity. Cells that were null for ILK failed to respond to the induction of invasion by LIMD2. This strongly suggests that LIMD2 potentiates its biologic effects through direct interactions with ILK, a signal transduction pathway firmly linked to cell motility and invasion. In summary, LIMD2 is a new component of the signal transduction cascade that links integrin-mediated signaling to cell motility/metastatic behavior and may be a promising target for controlling tumor spread. &lt;i&gt;Cancer Res; 74(5); 1390–403. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Evaluation of effective stress along the border of lateral notches (2016)

Abstract This paper analyses the issue of defect nucleation due to fatigue loading in notched components where cracks occur in the proximity of the zone where the major stress gradient occurs. On the basis of recent experimental results where the defects do not nucleate at the notch tip, the effective stress evaluated by means of the implicit gradient approach, can explain the reasons for this apparent discrepancy. Furthermore, in order to find a kind of notch that underlines the nucleation outside the maximum stress zone, rectangular lateral notches have been investigated. Rectangular notches could provide an interesting theoretical and experimental benchmark or reference case in order to validate effective stress definitions. The linear elastic stress field at edges, corners and in the surrounding material of rectangular, sharp or rounded lateral notches has been analysed by means of the implicit gradient approach. The consequent effective values of these notches are evaluated in relation to brittle fractures or their predicted fatigue strength values.
Double electron capture: Complex amplitudes from Auger anisotropy measurements (1996)

We report the scattering angle dependence of the complex population amplitudes of magnetic substates formed in doubly excited C3+ ions in double electron transfer from He onto C5+ projectiles. These results are derived from analysis of the anisotropic distribution of Auger electron/scattered ion coincidence events. Relative velocities in the range 0.2–0.4 au. have been studied. The results are the most complete experimental description of the double electron capture process, and provide insight into the impact parameter dependence of the orientation of the double excited electron wave function and the angular momentum transfered from the nuclear to the electron motion.
Dynamic Euler Diagram Drawing (2005)

In this paper we describe a method to lay out a graph enhanced Euler diagram so that it looks similar to a previously drawn graph enhanced Euler diagram. This task is nontrivial when the underlying structures of the diagrams differ. In particular, if a structural change is made to an existing drawn diagram, our work enables the presentation of the new diagram with minor disruption to the user's mental map. As the new diagram can be generated from an abstract representation, its initial embedding may be very different from that of the original. We have developed comparison measures for Euler diagrams, integrated into a multicriteria optimizer, and applied a force model for associated graphs that attempts to move nodes towards their positions in the original layout. To further enhance the usability of the system, the transition between diagrams can be animated
In utero exposure to parabens and early childhood BMI z-scores – Associations between placental ethyl paraben, longitudinal BMI trajectories and cord blood metabolic biomarkers (2021)

Prenatal EtP exposure may affect early childhood BMI. The association of placental EtP with cord blood GGT and glucose levels provides a starting point for further research on mechanisms of paraben-related metabolic processes in utero.
Platelet-Rich Plasma Products in Sports Medicine (2011)

Platelet-rich plasma (PRP) therapy is a recently developed technique that uses a concentrated portion of autologous blood to try to improve and accelerate the healing of various tissues. There is considerable interest in using these PRP products for the treatment of musculoskeletal disorders, particularly athletic injuries. Because PRP products are safe and easy to prepare and administer, there has been increased attention toward using PRP in numerous clinical settings. Platelet-rich plasma has been used to treat conditions such as lateral epicondylitis, ligament and muscle strains, and tears of the rotator cuff, anterior cruciate ligament, and Achilles tendon. Platelet-rich plasma can be applied at the site of injury either during surgery or through an injection performed in the physician's office. The benefits of PRP therapy appear to be promising, and many investigators are exploring the ways in which this therapy can be used in the clinical setting. However, there is little published clinical evidence that proves its efficacy in treating the multitude of injuries/disorders that are thought to benefit from PRP. The purpose of this article is to review the current evidence on PRP therapy.
Mechanism of Visceral Fat Reduction in Tsumura Suzuki Obese, Diabetes (TSOD) Mice Orally Administered β-Cryptoxanthin from Satsuma Mandarin Oranges (Citrus unshiu Marc) (2011)

The carotenoid β-cryptoxanthin (β-CRX) is abundant in Satsuma mandarins (Citrus unshiu Marc). Several studies have shown a relationship between Satsuma mandarin consumption and a low risk of several diseases, for example, diabetes, gout, and hypertension, suggesting β-CRX involvement in disease prevention. We investigated the effect of β-CRX on mildly obese males. β-CRX administration reduced visceral adipose tissue, body weight, and abdominal circumference. However, the detailed mechanism by which β-CRX mediates these changes remains unknown. To identify this mechanism, we used an obese model mouse (TSOD). Oral β-CRX administration repressed body weight, abdominal adipose tissue weight, and serum lipid concentrations in TSOD; these results are identical to previous human trial results. β-CRX administration significantly repressed adipocyte hypertrophy. Gene expression analysis strongly indicated that β-CRX can alter cytokine secretion and cell proliferation. These results suggest that β-CRX derived from Satsuma mandarins can help prevent obesity by repressing hypertrophy of abdominal adipocytes.
Speciation of Chromium by Direct Coupling of Ion Exchange Chromatography With Inductively Coupled Plasma Mass Spectrometry (1997)

Ion exchange chromatography has been coupled with inductively coupled plasma mass spectrometry (ICP-MS) for the element speciation of chromium. Hydraulic high pressure nebulization was used for sample introduction with high aerosol efficiency. It was the particular aim of this work to exclusively use nitric acid for elution in order to reduce interferences in ICP-MS. Therefore, an anion exchange pre-column IonPac-AG5 (Dionex, Idstein, Germany) with a length of 50 mm and an id of 4 mm has been operated as a mixed-mode column, which shows cation exchange capabilities too. The column was operated at a flow rate of 1.2 ml min–1 and samples were injected by use of a sample loop with a volume of 100 µl. Both CrVI anions and CrIII cations could be retained on the column, and optimum results concerning chromatographic and mass spectrometric conditions were finally achieved with discontinuous elution in two steps by injection of 0.3 m (pH 0.5) HNO3 for CrVI and subsequently of 1.0 m (pH 0) HNO3 for CrIII. Detection limits just above 0.1 µg l–1 could be realized.
High-Intensity Interval Training Improves Aerobic Capacity Without a Detrimental Decline in Blood Glucose in People With Type 1 Diabetes (2018)

Six weeks of HIT improved V˙o2peak and aPWV to a similar extent as MICT. That BG levels remained stable during HIT in the fed state but consistently fell during MICT suggests HIT may be the preferred training mode for some people with T1D.
Chemical Interpretation of Charged Point Defects in Semiconductors: A Case Study of Mg2Si (2021)

The number of excess charge carriers generated by a point defect, defined by the "charge state" of a defect, is oftentimes an important quantity used to engineer the electronic properties of semiconductors. Here, we develop a molecular orbital theory-based framework for interpreting the charge state(s) of a point defect, which is based on local chemical interactions between the defect and the atoms surrounding the defect site. We demonstrate how the framework can be applied to native defects in Mg2Si, such as interstitials, vacancies, and antisite defects, by utilizing symmetry principles and Density Functional Theory calculations. We anticipate that such an interpretive framework will guide efforts to engineer electronic and optical properties of semiconductors through manipulation of intrinsic and extrinsic defects.
Regarding the Congruence Between 2 Circulating Tumor DNA Sequencing Assays (2018)

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Eucalyptus virens, a new species of Ironbark form Queensland. (1986)

Eucalyptus virens, a new species of ironbark from Queensland, is described and illustrated and distribution maps are provided. The new species belongs in the informal 'E. series Paniculatae' Pryor &amp; Johnson and is closest to E. panda S. T. Blake. E. virens is known only from three widely separated populations, viz. north-west of Injune (upper Maranoa River), north of Tara and east of Inglewood. Two of these populations are endangered by proposed or potential land development.
Beta Interferon Subtype 1 Induction by Tumor Necrosis Factor (1989)

Tumor necrosis factor (TNF) induces an antiviral state in various cell lines. This antiviral state is quite similar to that established by interferon (IFN), e.g., TNF treatment of HEp-2 cells induces 2',5'-oligoadenylate synthetase activity. Both antiviral activity and synthetase induction are greatly reduced when TNF treatment occurs in the presence of a beta interferon subtype 1 (IFN-beta 1)-neutralizing antiserum. However, no one has yet directly demonstrated IFN-beta 1 induction, either as an antiviral activity in supernatants from TNF-treated cells or as IFN-specific mRNA by Northern (RNA) blot analysis. We have adopted a recently described in vitro DNA amplification protocol for the detection of specific RNAs. By applying this method to RNA from HEp-2 cells, we could demonstrate increased levels of IFN-beta 1-specific transcripts after TNF treatment. Dose response and kinetics of IFN-beta 1 induction coincided with the TNF-induced antiviral state. Nuclear run-on analysis showed enhanced transcriptional activity of the IFN-beta 1 gene in TNF-treated cells. Our data substantiate a role of IFN-beta 1 as mediator of the biological activity of TNF in HEp-2 cells.
EBIS charge breeder for radioactive ion beams at ATLAS (2010)

The construction of the Californium Rare Isotope Breeder Upgrade (CARIBU) for the Argonne National Laboratory ATLAS facility is completed and its commissioning is being performed. In its full capacity, the CARIBU facility will use fission fragments from a 1 Curie (Ci) 252Cf source. The ions will be thermalized and collected into a low-energy ion beam by a helium gas catcher, mass analyzed by an isobar separator, and charge bred to higher charge states for acceleration in ATLAS. To reach energies E/A 10 MeV/u, one should inject ions with charge-to-mass ratio (q/A) ⩾ 1/7 into the ATLAS linac. In the first stage, the existing Electron Cyclotron Resonance (ECR) ion source will be used as a charge breeder. The maximum intensity of radioactive ion beams at the output of the gas catcher will not exceed 107 ions per second. A charge breeder based on an Electron Beam Ion Source (EBIS) has significant advantages over the ECR option for ion beam intensities up to about 109 ions per second, providing 3-4 times higher efficiency and significantly better purity of highly charged radioactive ion beams for further acceleration. The proposed EBIS project for CARIBU will heavily utilize state-of-the-art EBIS technology recently developed at Brookhaven National Laboratory. This will allow us to reduce both the project cost and timescale, simultaneously insuring reliable technical realization of the cutting-edge technology. Several parameters of the CARIBU EBIS charge breeder (EBIS-CB) will be relaxed with respect to the BNL EBIS in favor of higher reliability and lower cost. Technical performance of the CARIBU charge breeder will not suffer from such a relaxation and will provide high efficiency for a whole range of radioactive ion beams. The goal of this paper is to present the initial design of the EBIS charge breeder for radioactive ion beams at ATLAS.
Losses in hybrid and active magnetic bearings applied to long term flywheel energy storage (2010)

In this work, Radial Active Magnetic Bearings (RAMB) and PM-biased Hybrid Radial Magnetic Bearings (HRMB) were designed and optimized in the case of the Flywheel Long Term Energy Storage (LTFES). Taking into account the amplitude of external disturbance as well as unbalance force as load capacity, the effect of losses (non including losses in the power electronic) on the both RAMB and PM-biased HRMB was studied. Flywheel discharge times have been computed and drawn for a flywheel rotating at a nominal speed of 9000 rpm and self-discharging down to half-speed (4500 rpm). The evolution of this time duration versus mass of bearings is shown for different values of unbalance forces for these two magnetic bearing configurations. (6 pages)
Stereotaxic Administration of 1‐Methyl‐4‐Phenylpyridinium Ion (MPP+) Decreases Striatal Fructose 2,6‐Bisphosphate in Rats (1994)

The stereotaxic administration of 1-methyl-4-phenylpyridinium ion (MPP+) into the neostriatum of male rats caused a lesion that resulted in a large dose-dependent loss of striatal fructose 2,6-bisphosphate; initial values were restored 5 days after the treatment. This effect was not protected by systemic administration of MK-801 or by nitroarginine. The content of hexose 6-phosphates and ATP was also reduced by MPP+ treatment, whereas lactate was increased. Biochemical and histological results suggested that MPP+ caused a nonselective cell death, followed by a pronounced astroglial response, parallel to fructose 2,6-bisphosphate recovery. The stereotaxic administration of rotenone showed a different time effect on fructose 2,6-bisphosphate cerebral content, with a significantly faster recovery. These results indicate that cerebral fructose 2,6-bisphosphate may be a sensitive metabolite related to brain damage caused by potent neurotoxins such as MPP+. On the other hand, they show that MPP+ acts in the brain through a quick, strong cytotoxic mechanism, which probably involves mechanisms other than mitochondrial chain blockage.
SU‐E‐T‐517: Analytic Formalism to Compute in Real Time Dose Distributions Delivered by HDR Units (2014)

Purpose: Develop an analytical algorithm to compute the dose delivered by Ir‐192 dwell positions with high accuracy using the 3‐dimensional (3D) dose distribution of an HDR source. Using our analytical function, the dose delivered by an HDR unit as treatment progresses can be determined using the actual delivered temporal and positional data of each individual dwell. Consequently, true delivered dose can be computed when each catheter becomes active. We hypothesize that the knowledge of such analytical formulation will allow developing HDR systems with a real time treatment evaluation tool to avoid mistreatments. Methods: In our analytic formulation, the dose is computed by using the full anisotropic function data of the TG 43 formalism with 3D ellipsoidal function. The discrepancy between the planned dose and the delivered dose is computed using an analytic perturbation method over the initial dose distribution. This methodology speeds up the computation because only changes in dose discrepancies originated by spatial and temporal deviations are computed. A dose difference map at the point of interest is obtained from these functions and this difference can be shown during treatment in real time to examine the treatment accuracy. Results: We determine the analytical solution and a perturbation function for the 3 translational 3 rotational, and 1D temporal errors in source distributions. The analytic formulation is a sequence of simple equations that can be processed in any modern computer in few seconds. Because computations are based in an analytical solution, small deviations of the dose when sub‐millimeter positional changes occur can be detected. Conclusions: We formulated an analytical method to compute 4D dose distributions and dose differences based on an analytical solution and perturbations to the original dose. This method is highly accurate and can be
A Probabilistic Framework for Performance-Based Durability Engineering: Application to Corrosion in Reinforced Concrete (2011)

A proposed probabilistic framework for performance-based durability engineering is motivated by the successful implementation of the Pacific Earthquake Engineering Research Center's framework for performance-based earthquake engineering. Both approaches combine several stages of analysis linked through a limited set of "pinch point" variables, which allows modeling flexibility. The analysis extends to the computation of information useful to decision makers, and can also provide sensitivity analysis of the modeling stages to be used to direct future research. The major stages, variables, datasets, and models to be used are outlined with corrosion in reinforced concrete as the cause of deterioration.
High-field MRI-compatible needle placement robot for prostate interventions. (2011)

This paper presents the design of a magnetic resonance imaging (MRI) compatible needle placement system actuated by piezoelectric actuators for prostate brachytherapy and biopsy. An MRI-compatible modular 3 degree-of-freedom (DOF) needle driver module coupled with a 3-DOF x-y-z stage is proposed as a slave robot to precisely deliver radioactive brachytherapy seeds under interactive MRI guidance. The needle driver module provides for needle cannula rotation, needle insertion and cannula retraction to enable the brachytherapy procedure with the preloaded needles. The device mimics the manual physician gesture by two point grasping (hub and base) and provides direct force measurement of needle insertion force by fiber optic force sensors. The fabricated prototype is presented and an experiment with phantom trials in 3T MRI is analyzed to demonstrate the system compatibility.
Photo search by face positions and facial attributes on touch devices (2011)

With the explosive growth of camera devices, people can freely take photos to capture moments of life, especially the ones accompanied with friends and family. Therefore, a better solution to organize the increasing number of personal or group photos is highly required. In this paper, we propose a novel way to search for face images according facial attributes and face similarity of the target persons. To better match the face layout in mind, our system allows the user to graphically specify the face positions and sizes on a query "canvas," where each attribute or identity is defined as an "icon" for easier representation. Moreover, we provide aesthetics filtering to enhance visual experience by removing candidates of poor photographic qualities. The scenario has been realized on a touch device with an intuitive user interface. With the proposed block-based indexing approach, we can achieve near real-time retrieval (0.1 second on average) in a large-scale dataset (more than 200k faces in Flickr images).
Palladium particles embedded into silica optical fibers for hydrogen gas detection (2014)

In this paper, we report the fabrication and characterization of a new concept of optical fibers whose cladding is composed of palladium particles embedded into the silica glass cladding. Since conventional fiber processes are not suitable for such realizations, we developed an original process based on powder technology to prepare our specific preforms. Step, graded index and photonic crystal optical fibers with original shapes were realized. The use of high purity powders as raw materials combined to a specific preforms heat treatment allowed the fabrication of resistant and long length metal-cladding optical fibers. Microstructured Pd-SiO2 composite cladding optical fibers with single-mode behavior and optical losses lower than 2 dB/m at 1530 nm were characterized. Hydrogen-induced attenuation sensitivity of these fibers at the 1245 nm wavelength was demonstrated after long H2 exposure. Dehydrogenation kinetics calculations and experiments were studied.
Stereoselective Synthesis of a CGlycosidic Analog of N‐Glucoasparagine (1997)

The orthogonally protected gylcosylated amino acid building block 1 for the synthesis of peptidomimetics was prepared by the coupling of an amino acid aldehyde with a glycosyl dianion of glucosamine. This new C-glycosylated amino acid displays an improved metabolic stability and thus an improved bioavailability because of the single carbon chain between the sugar residue and the amino acid and because of the CC linkage at the anomeric center.
Preliminary design of a supersonic cruise aircraft high-pressure turbine (1983)

Development of the supersonic cruise aircraft engine continued in this National Aeronautics and Space Administration (NASA) sponsored Pratt and Whitney program for the Preliminary Design of an Advanced High-Pressure Turbine. Airfoil cooling concepts and the technology required to implement these concepts received particular emphasis. Previous supersonic cruise aircraft mission studies were reviewed and the Variable Stream Control Engine (VSCE) was chosen as the candidate or the preliminary turbine design. The design was evaluated for the supersonic cruise mission. The advanced technology to be generated from these designs showed benefits in the supersonic cruise application and subsonic cruise application. The preliminary design incorporates advanced single crystal materials, thermal barrier coatings, and oxidation resistant coatings for both the vane and blade. The 1990 technology vane and blade designs have cooled turbine efficiency of 92.3 percent, 8.05 percent Wae cooling and a 10,000 hour life. An alternate design with 1986 technology has 91.9 percent efficiency and 12.43 percent Wae cooling at the same life. To achieve these performance and life results, technology programs must be pursued to provide the 1990's technology assumed for this study.