gebhart/patrepeval huggingface dataset:
Bandstop filter based on composite right/left handed transmission line at dual WLAN bands (2011)

A compact dual-band bandstop filter (BSF) based on composite right/left handed transmission line (CRLH TL)is proposed and designed without any external impedance matching block. The filter is to suppress the interference of the signal at 5.2 and 5.8 GHz, which is the Unlicensed National Information Infrastructure, radio following the IEEE 802.11a standard and system. The filter is realized by using interdigital capacitor coupled with shorted stub periodic structure based on the characteristic of CRLH TLs. Single and dual-band BSFs are designed, fabricated and measured to validate the design principle. The filter is designed in single layer and the length of the resonators is 3.48 and 4.08 mm, corresponding to the filters operating at 5.8 and 5.2 GHz, respectively. The total length of the filter is 28.89 mm. Designed topologies of dual-band BSFs with centre frequencies of 5.2 GHz and 5.8 GHz exhibit an rejection better than 15 dB with a 10 dB bandwidth of 2.5% (5.125-5.255 GHz) and 3.2% (5.726-5.907 GHz), respectively. The measured largest signal rejections are 15.98 dB at 5.23 GHz and 15.98 dB at 5.6 GHz. The 10-dB fractional band-width (FBW) is 3% from 5.14 GHz to 5.30 GHz and 1.25% from 5.57 GHz to 5.64 GHz, and the measured insertion loss is 2.74 dB at 5.4 GHz.
Electrical Isolation Performance of Microgasket Technology for Implant Packaging (2020)

High-channel-count neural interfaces are typically packaged by being permanently bonded to their packaged electronics followed by encapsulation. Such interfaces are often intimately integrated into neural tissue, their removal to replace the battery or upgrade electronics is not undesirable. Gaskets are widely used to provide liquid/electrical isolation and to seal the connection between two or more mating parts. Pressure-driven microgaskets are well established in the field of microfluidics. Although rematable microgaskets for fluidic interconnects exist, the use of microgaskets for electrical isolation have not been demonstrated. Our approach is to electrically isolate 2-D arrays of contact pads using a compressible silicone microgasket. Electrochemical impedance spectroscopy (EIS) was used to quantify the electrical isolation of the microgasket on contact pads, which were formed in a polyimide flex circuit, as a function of frequency after being soaked in saline. Experiments have shown that the compressed sub-millimeter PDMSe microgasket can provide excellent isolation (i.e., >30 MΩ at 1 KHz) that is comparable to the other more conventional packaging methods, such as encapsulation in polydimethylsiloxane elastomer (PDMSe) or parylene-C. Our microgasket-based approach should be scalable to high channel counts and high channel densities enabling much smaller and higher-performance neural implants.
Adaptive Sequence Phase Detection (2019)

A phase detection sequence is a length-n cyclic sequence such that the location of any length-k contiguous subsequence can be determined from a noisy observation of that subsequence. In this paper, we consider the problem of designing phase detection sequences that allow adaptive phase detection for different noise levels at the detector. We discuss two detection scenarios: depending on the noise level, the detector adaptively chooses the length k of the observation period, or adaptively chooses the detection resolution. We establish the optimal rate regions in both settings.
Deflection Limits of Structures for Train Speed-up (2005)

A current design standard provides the deflection limits of structures from the viewpoint of running safety and riding comfort up to 260km/h operation. In this study, the influence of dominant parameters on the dynamic response of vehicles running on structures was examined by numerical analysis to expand the applicability of the design standard in the high-speed range. In addition, the dynamic responses of vehicles on 17 actual structures of various types with different span lengths were measured mainly through vehicle running tests. Carbody acceleration was also measured in relation to structure deflection and studied from the viewpoint of the span length and rigidity of the structures. Peak-to-peak amplitudes of carbody acceleration were approximately 1.5m/s² or less on all structures. A new provision for the railway design standard was proposed based on this study.
Some Computer Experiments in Picture Processing for Bandwidth Reduction (1971)

Some computer experiments in processing still pictures for bandwidth reduction are described. In the scheme studied, a picture is partitioned into subpictures each of which is encoded separately. A subpicture is expressed as a linear combination of a finite set of specially chosen basis subpictures. Quantized versions of the coefficients of this expansion are transmitted as binary digits. Using this procedure, we were able to obtain pictures of good quality using approximately 2 bits per picture-element; we were unable to do so at lower bit-rates. Some general comments on the encoding of pictures are included.
Diastereoselective synthesis of hydroxylated dihydrothymidines resulting from oxidative stress (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiastereoselective synthesis of hydroxylated dihydrothymidines resulting from oxidative stressMark R. Barvian and Marc M. GreenbergCite this: J. Org. Chem. 1993, 58, 22, 6151–6154Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/jo00074a057https://doi.org/10.1021/jo00074a057research-articleACS PublicationsRequest reuse permissionsArticle Views190Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multimode mediated qubit-qubit coupling and dark-state symmetries in circuit quantum electrodynamics (2011)

Microwave cavities with high quality factors enable coherent coupling of distant quantum systems. Virtual photons lead to a transverse interaction between qubits when they are nonresonant with the cavity but resonant with each other. We experimentally investigate the inverse scaling of the interqubit coupling with the detuning from a cavity mode and its proportionality to the qubit-cavity interaction strength. We demonstrate that the enhanced coupling at higher frequencies is mediated by multiple higher-harmonic cavity modes. Moreover, we observe dark states of the coupled qubit-qubit system and analyze their relation to the symmetry of the applied driving field at different frequencies.
Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy (2021)

Axonal degeneration is an early and ongoing event that causes disability and disease progression in many neurodegenerative disorders of the peripheral and central nervous systems. Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of morbidity and the main cause of dose reductions and discontinuations in cancer treatment. Preclinical evidence indicates that activation of the Wallerian-like degeneration pathway driven by sterile alpha and TIR motif containing 1 (SARM1) is responsible for axonopathy in CIPN. SARM1 is the central driver of an evolutionarily conserved programme of axonal degeneration downstream of chemical, inflammatory, mechanical or metabolic insults to the axon. SARM1 contains an intrinsic NADase enzymatic activity essential for its pro-degenerative functions, making it a compelling therapeutic target to treat neurodegeneration characterized by axonopathies of the peripheral and central nervous systems. Small molecule SARM1 inhibitors have the potential to prevent axonal degeneration in peripheral and central axonopathies and to provide a transformational disease-modifying treatment for these disorders. Using a biochemical assay for SARM1 NADase we identified a novel series of potent and selective irreversible isothiazole inhibitors of SARM1 enzymatic activity that protected rodent and human axons in vitro. In sciatic nerve axotomy, we observed that these irreversible SARM1 inhibitors decreased a rise in nerve cADPR and plasma neurofilament light chain released from injured sciatic nerves in vivo. In a mouse paclitaxel model of CIPN we determined that Sarm1 knockout mice prevented loss of axonal function, assessed by sensory nerve action potential amplitudes of the tail nerve, in a gene-dosage-dependent manner. In that CIPN model, the irreversible SARM1 inhibitors prevented loss of intraepidermal nerve fibres induced by paclitaxel and provided partial protection of axonal function assessed by sensory nerve action potential amplitude and mechanical allodynia.
Vibration Control through Passive Constrained Layer Damping and Active Control (1997)

To add damping to systems, viscoelastic materials (VEM) are added to structures. In order to enhance the damping effects of the VEM, a constraining layer is attached, creating a passive constrained layer damping (PCLD) treatment. When this constraining layer is an active element, the treatment is called active constrained layer damping (ACLD). Recently, the investigation of ACLD treatments has shown it to be an effective method of vibration suppression. In this paper, the treatment of a beam with a separate active and PCLD element will be investigated. Two new hybrid variations will be introduced. A Ritz-Galerkin approach is used to obtain discretized equations of motion. The damping is modeled using the Golla-Hughes-McTavish (GHM) method and the system is analyzed in the time domain. By optimizing on the performance and control effort for both the active and passive case, it will be shown that hybrid treatment is capable of lower control effort with more inherent damping, and is therefore a better approach to suppressing vibration than ACLD.
Condensed Matter Physicists Shrink Their Horizons (1993)

In the world of the condensed matter physicist, a micron is a chasm and a millimeter an ocean. At the March American Physical Society meeting in Seattle, some of the 4500 physicists probed the hazards of the micro world, where weird quantum effects can scramble information. Others outlined its opportunities: Molecular engineering that is leading to new information storage materials, and minute structures that could form tethers and containers in some future nanotechnology.
FigureS2 from Early Evaluation of Circulating Tumor DNA as Marker of Therapeutic Efficacy in Metastatic Colorectal Cancer Patients (PLACOL Study) (2023)

&lt;p&gt;Supplementary Figure 2. Impact of baseline ctDNA concentration on overall survival (OS) in the subgroup of patients with ctDNA detectable at baseline (n=63).&lt;/p&gt;
Atomic‐Scale Observation of the Metal–Promoter Interaction in Rh‐Based Syngas‐Upgrading Catalysts (2019)

Abstract The direct conversion of syngas to ethanol, typically using promoted Rh catalysts, is a cornerstone reaction in CO 2 utilization and hydrogen storage technologies. A rational catalyst development requires a detailed structural understanding of the activated catalyst and the role of promoters in driving chemoselectivity. Herein, we report a comprehensive atomic‐scale study of metal–promoter interactions in silica‐supported Rh, Rh–Mn, and Rh–Mn–Fe catalysts by aberration‐corrected (AC) TEM. While the catalytic reaction leads to the formation of a Rh carbide phase in the Rh–Mn/SiO 2 catalyst, the addition of Fe results in the formation of bimetallic Rh–Fe alloys, which further improves the selectivity and prevents the carbide formation. In all promoted catalysts, Mn is present as an oxide decorating the metal particles. Based on the atomic insight obtained, structural and electronic modifications induced by promoters are revealed and a basis for refined theoretical models is provided.
Propagation of SIV Vectors by Genetic Complementation with a Heterologous env Gene (1992)

In order to study SIV replication over a single round of replication virus particles were generated that contain a replication-defective vector containing a selectable marker. Genetic complementation between an env-deficient SIV variant and plasmid that expresses the env gene of an amphotropic murine retrovirus resulted in infectious SIV particles containing the vector. These pseudotyped particles exhibited an expanded host range through the use of an alternative receptor. This system should be useful in the genetic analysis of SIV nucleic acid replication. To determine whether the terminal cis acting components of the SIV genome might be sufficient for viral nucleic acid propagation a vector was generated which lack the internally located rev-responsive element. Propagation of this vector was reduced by at least 100-fold.
Hypertensive emergency presenting as blurry vision in a patient with hypertensive chorioretinopathy (2015)

A 42-year-old man presented with 3 weeks of blurry vision in the right eye. His exam was significant for decreased vision in the right eye, diffuse retinopathy in both eyes, and serous retinal detachment in the right eye. The patient was found to be hypertensive with blood pressure of 256/160 mmHg. He was diagnosed with hypertensive emergency with end-organ damage due to features of hypertensive chorioretinopathy. He was admitted with abnormal urinalysis, elevated troponin, and abnormal EKG. After appropriate control of his blood pressure, his vision and his labs normalized. Hypertensive emergencies can be manifested first in the eyes. When the choroid is associated, the hypertensive event is often more acute and associated with increased morbidity. It is imperative to obtain a fundus exam in any patient with elevated blood pressure and concomitant vision complaints.
Some recent problems in the field of microwave ferrites (1973)

Some recent developments and problems in the field of microwave ferrites will be reviewed. Properties which are considered interesting will be presented and discussed for materials with new chemical formulas in the spinel and garnet diagrams. Then we shall give an example of the physico-chemical problems brought up by the synthesis of ferrites with very low dielectric losses. Among the problems related to the micro-structure, materials with very small grains and those without porosity will be examined. The cation distribution between the crystallographic sites will be studied in another chapter. Then we shall try to discuss the experimental data available on microwave relaxation in polycrystalline ferrites. For that purpose, the effects of the relaxing ions and of the granular structure will be compared on <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\DeltaH, \DeltaH_{eff}</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\DeltaH_{k}</tex> .
Flex-SURF: A Flexible Architecture for FPGA-Based Robust Feature Extraction for Optical Tracking Systems (2010)

In this paper, we propose a novel architecture to accelerate the Speeded Up Robust Features (SURF) algorithm by the use of configurable hardware. SURF is used in optical tracking systems to robustly detect distinguishable features within an image in a scale and rotation invariant way. In its performance critical part, SURF computes convolution filters at multiple scale levels without the need to create down-sampled versions of the original image. However, the algorithm exposes a very irregular memory access pattern. We designed a configurable and scalable architecture to overcome these memory access issues without the need to use any internal block RAM resources of the FPGA. The complete detector and descriptor stage of SURF has been implemented and validated in a Virtex 5 FPGA.
PG-M1: a new monoclonal antibody directed against a fixative-resistant epitope on the macrophage-restricted form of the CD68 molecule. (1993)

A new anti-macrophage monoclonal antibody (PG-M1) was produced by immunizing BALB/c mice with fresh spleen cells from a patient with Gaucher's disease. PG-M1 reacts strongly with a fixative-resistant epitope of an intracytoplasmic molecule, selectively expressed by virtually all macrophages of the human body. Although attempts to immunoprecipitate the molecule recognized by PG-M1 have failed so far, the reactivity of the antibody with COS-1 and WOP cells transfected with a human complementary DNA clone encoding for the CD68 antigen suggests that PG-M1 is a new member of the CD68 cluster. However, unlike other CD68 antibodies (KP1, EBM11, etc.), which react with both macrophages and myeloid cells, PG-M1 detects a fixative-resistant epitope on the macrophage-restricted form of the CD68 antigen. In 957 routinely fixed, paraffin-embedded samples, PG-M1 showed a more restricted reactivity with elements of the monocyte/macrophage lineage than the previously described monoclonal antibodies MAC-387 (anti-calgranulins), KP1 (CD68) and Ki-M1P. Among hematological malignancies, PG-M1 only labels acute leukemias of M4 and M5 type and rare examples of malignant histiocytosis/true histiocytic sarcoma. In contrast, acute leukemias of the M1, M2, M3, M6, M7, and L1-L3 types, non-Hodgkin's lymphomas, and Hodgkin and Reed-Sternberg cells of Hodgkin's disease are consistently PG-M1-negative. In the daily diagnostic practice, PG-M1 seems to be particularly valuable for the diagnosis of myelomonocytic or monocytic leukemia and neoplasms of true histiocytic origin in routine paraffin sections.
Loss of Chloride Channel 6 (CLC-6) Affects Vascular Smooth Muscle Contractility and Arterial Stiffness via Alterations to Golgi Calcium Stores (2021)

Genome-wide association studies have found a number of potential genes involved in blood pressure regulation; however, the functional role of many of these candidates has yet to be established. One such candidate gene is <i>CLCN6</i>, which encodes the transmembrane protein, chloride channel 6 (ClC-6). Although the <i>CLCN6</i> locus has been widely associated with human blood pressure regulation, the mechanistic role of ClC-6 in blood pressure homeostasis at the molecular, cellular, and physiological levels is completely unknown. In this study, we demonstrate that rats with a functional knockout of ClC-6 on the Dahl Salt-Sensitive rat background (SS-<i>Clcn6</i>) have lower diastolic but not systolic blood pressures. The effect of diastolic blood pressure attenuation was independent of dietary salt exposure in knockout animals. Moreover, SS-<i>Clcn6</i> rats are protected from hypertension-induced cardiac hypertrophy and arterial stiffening; however, they have impaired vasodilation and dysregulated intracellular calcium handling. ClC-6 is highly expressed in vascular smooth muscle cells where it is targeted to the Golgi apparatus. Using bilayer electrophysiology, we provide evidence that recombinant human ClC-6 protein can function as a channel. Last, we demonstrate that loss of ClC-6 function reduces Golgi calcium stores, which may play a previously unidentified role in vascular contraction and relaxation signaling in vascular smooth muscle cells. Collectively, these data indicate that ClC-6 may modulate blood pressure by regulating Golgi calcium reserves, which in turn contribute to vascular smooth muscle function.
Abstract 3592: Early Detection Of CD4-positive Lymphocytes In Adipose Tissue During The Development Of Insulin Resistance (2007)

Background: Adipose tissue inflammation may play a critical role in the pathogenesis of insulin resistance (IR) and arteriosclerosis. Previous work has mainly focused on the role of macrophages in human adipose tissue, but little is known about pro-inflammatory T-lymphocytes. Therefore the present study examined the role of CD4-positive lymphocytes in adipose tissue inflammation and IR. Results: Both, CD4-positive lymphocytes and macrophages are present in human visceral adipose tissue as determined by immunohistochemical staining. Most macrophages were HLA-DR positive, reflecting activation through IFNγ, a cytokine released from CD4-positive lymphocytes. Furthermore, SDF-1α, a T-cell chemotactic protein, was also detectable in human adipose tissue. RT-PCR analyses confirmed the expression of IFNγ and SDF1α in visceral adipose tissue. Freshly isolated human adipocytes as well SGBS adipocyte cells express SDF-1α with a down regulation of its expression during adipocyte differentiation in both cell types. In a mouse model of IR, high fat diet induced IR already after 5 weeks which was associated with a marked lymphocyte infiltration in visceral adipose tissue as determined by immunohistochemical staining and RT-PCR. In contrast, macrophages were absent after 5 weeks of diet but could be detected at week 10, suggesting early infiltration of lymphocytes during the development of IR. Conclusion: Pro-inflammatory T-lymphocytes are present in visceral adipose tissue and may contribute to local inflammatory cell activation before the appearance of macrophages. These data suggest that lymphocytes may play an important role in the initiation and perpetuation of adipose tissue inflammation as well as the development of insulin resistance.
The Antidepressant Sertraline Provides a Promising Therapeutic Option for Neurotropic Cryptococcal Infections (2012)

Therapeutic treatment for systemic mycoses is severely hampered by the extremely limited number of antifungals. The difficulty of treatment of fungal infections in the central nervous system is further compounded by the poor central nervous system (CNS) penetration of most antifungals due to the blood-brain barrier. Only a few fungistatic azole drugs, such as fluconazole, show reasonable CNS penetration. Here we demonstrate that sertraline (Zoloft), the most frequently prescribed antidepressant, displays potent antifungal activity against Cryptococcus neoformans, the major causative agent of fungal meningitis. In in vitro assays, this neurotropic drug is fungicidal to all natural Cryptococcus isolates tested at clinically relevant concentrations. Furthermore, sertraline interacts synergistically or additively with fluconazole against Cryptococcus. Importantly, consistent with our in vitro observations, sertraline used alone reduces the brain fungal burden at an efficacy comparable to that of fluconazole in a murine model of systemic cryptococcosis. It works synergistically with fluconazole in reducing the fungal burden in brain, kidney, and spleen. In contrast to its potency against Cryptococcus, sertraline is less effective against strains of Candida species and its interactions with fluconazole against Candida strains are often antagonistic. Therefore, our data suggest the unique application of sertraline against cryptococcosis. To understand the antifungal mechanisms of sertraline, we screened a whole-genome deletion collection of Saccharomyces cerevisiae for altered sertraline susceptibility. Gene ontology analyses of selected mutations suggest that sertraline perturbs translation. In vitro translation assays using fungal cell extracts show that sertraline inhibits protein synthesis. Taken together, our findings indicate the potential of adopting this antidepressant in treating cryptococcal meningitis.