gebhart/patrepeval huggingface dataset:
Contribución al conocimiento de la fenología, plantas huésped y parasitoides de Bazaria ruscinonella (Ragonot, 1888) (Lepidoptera; Pyralidae, Phycitinae) sobre suelos de yeso en Madrid y Zaragoza (2002)

espanolLa biologia de Bazaria ruscinonella (Ragonot, 1888) es poco conocida. En este articulo se describen las observaciones en cautividad de orugas recogidas tanto en Zaragoza como en Madrid sobre suelos de yeso. Se incluyen observaciones adicionales sobre sus plantas huesped, asi como datos ineditos sobre los parasitoides de las larvas. catalaLa biologia de Bazaria ruscinonella (Ragonot, 1888) es poc coneguda. En aquest article es descriuen les observacions en captivitat de larves recollides tant a Saragossa com a Madrid sobre sols guixencs. S'inclouen observacions addicionals sobre les larves i les seves plantes nutricies. Tambe es presenten dades inedites sobre els parasitoides de les larves. EnglishThe biology of Bazaria ruscinonella (Ragonot, 1888) is little known. The following short paper details the finding and subsequent rearing of this species from larvae collected in Zaragoza and Madrid on gypsum soils. Additional data on the food-plants of the moth are included, as well as original data on the larval parasitoids.
FAK Potentiates Rac1 Activation and Localization to Matrix Adhesion Sites: A Role for βPIX (2006)

FAK, a cytoplasmic protein tyrosine kinase, is activated and localized to focal adhesions upon cell attachment to extracellular matrix. FAK null cells spread poorly and exhibit altered focal adhesion turnover. Rac1 is a member of the Rho-family GTPases that promotes membrane ruffling, leading edge extension, and cell spreading. We investigated the activation and subcellular location of Rac1 in FAK null and FAK reexpressing fibroblasts. FAK reexpressers had a more robust pattern of Rac1 activation after cell adhesion to fibronectin than the FAK null cells. Translocation of Rac1 to focal adhesions was observed in FAK reexpressers, but seldom in FAK null cells. Experiments with constitutively active L61Rac1 and dominant negative N17Rac1 indicated that the activation state of Rac1 regulated its localization to focal adhesions. We demonstrated that FAK tyrosine-phosphorylated betaPIX and thereby increased its binding to Rac1. In addition, betaPIX facilitated the targeting of activated Rac1 to focal adhesions and the efficiency of cell spreading. These data indicate that FAK has a role in the activation and focal adhesion translocation of Rac1 through the tyrosine phosphorylation of betaPIX.
The Anticancer Potential of Plant-Derived Nutraceuticals via the Modulation of Gene Expression (2022)

Current studies show that approximately one-third of all cancer-related deaths are linked to diet and several cancer forms are preventable with balanced nutrition, due to dietary compounds being able to reverse epigenetic abnormalities. An appropriate diet in cancer patients can lead to changes in gene expression and enhance the efficacy of therapy. It has been demonstrated that nutraceuticals can act as powerful antioxidants at the cellular level as well as anticarcinogenic agents. This review is focused on the best studies on worldwide-available plant-derived nutraceuticals: curcumin, resveratrol, sulforaphane, indole-3-carbinol, quercetin, astaxanthin, epigallocatechin-3-gallate, and lycopene. These compounds have an enhanced effect on epigenetic changes such as histone modification via HDAC (histone deacetylase), HAT (histone acetyltransferase) inhibition, DNMT (DNA methyltransferase) inhibition, and non-coding RNA expression. All of these nutraceuticals are reported to positively modulate the epigenome, reducing cancer incidence. Furthermore, the current review addresses the issue of the low bioavailability of nutraceuticals and how to overcome the drawbacks related to their oral administration. Understanding the mechanisms by which nutraceuticals influence gene expression will allow their incorporation into an "epigenetic diet" that could be further capitalized on in the therapy of cancer.
Applications of an image segmentation technique to multibeam echo-sounder data (2002)

A segmentation algorithm has recently been presented for seafloor characterization from multibeam echosounder sonar images, accounting for angular variations of the backscattered signals obtained from training zones. This approach allows one to suppress the image effects due to seafloor topography and angle dependance. It is applied here to some real cases both in deep and shallow water, with data from two different echo-sounders at 13 kHz and 95 kHz. For every case the raw image, the angular backscattering patterns obtained on training zones, and the segmentation results are presented. The various limitations of the method are finally discussed: difficulties around the vertical of the sonar, too low number of training data, high dependence of the results on the quality of the echo-sounder processes and corrections. It is shown that such a segmentation is really effective despite non optimal data and difficult geological configurations.
Coherent control of electron spin qubits in silicon using a global field (2021)

Silicon spin qubits promise to leverage the extraordinary progress in silicon nanoelectronic device fabrication over the past half century to deliver large-scale quantum processors. Despite the scalability advantage of using silicon technology, realising a quantum computer with the millions of qubits required to run some of the most demanding quantum algorithms poses several outstanding challenges, including how to control so many qubits simultaneously. Recently, compact 3D microwave dielectric resonators were proposed as a way to deliver the magnetic fields for spin qubit control across an entire quantum chip using only a single microwave source. Although spin resonance of individual electrons in the globally applied microwave field was demonstrated, the spins were controlled incoherently. Here we report coherent Rabi oscillations of single electron spin qubits in a planar SiMOS quantum dot device using a global magnetic field generated off-chip. The observation of coherent qubit control driven by a dielectric resonator establishes a credible pathway to achieving large-scale control in a spin-based quantum computer.
Microwave Annealing as a Low Thermal Budget Technique for ZnO Thin-Film Transistors Fabricated Using Atomic Layer Deposition (2017)

Microwave annealing (MWA) and furnace annealing are compared for their low thermal budget capability to improve the characteristics of ZnO-based thin-film transistors (TFTs). Both the ZnO channel and the Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> gate dielectric are fabricated using atomic layer deposition. Using Si-wafer-susceptor assisted MWA with a substantial reduction of both annealing temperature and duration, significant improvements of the characteristics of the ZnO TFTs can be attained. A multi-step MWA process is found to further improve the characteristics of the TFTs. For the same microwave power and total duration, the field-effect mobility of the multi-step MWA TFT is 42% greater than that of the one-step MWA TFT with a similar sub-threshold swing. The multi-step MWA process can serve the purpose at temperatures as low as 220 °C.
Marine deep seismic sounding off the Coast of British Columbia (2010)

A marine seismic system for recording near-vertical incidence to wide-angle reflected waves and refracted waves with penetration to the bottom of the crust (deep seismic sounding or DSS) has been developed. In a two ship-operation, signals from six individual hydrophones are recorded in digital form on the receiving ship. To provide origin times and facilitate subsequent processing, signals from a single hydrophone are recorded in FM mode on the shooting ship. During 1973, DSS profiles about 20km in length were recorded in three regions off the west coast of Canada: the Hudson '70 survey area, west of the Queen Charlotte Islands near 51°N, 133°W; off Queen Charlotte Sound; and in Cascadia Basin west of central Vancouver Island. The recorded data were processed with various digital techniques such as autopower spectrum analysis, band-pass filtering, deconvolution, velocity spectrum analysis, and stacking. After compilation in record sections, the data were interpreted in terms of velocity-versus-depth models of the oceanic crust. Two kinds of models were derived for the refraction data, models are based on a traveltime and amplitude interpretation made by comparing the observed data with synthetic seismograms. For the reflection data, the models are based on a T²-X² analysis of seismic phases. The crustal models derived from the two approaches indicate the same basic crustal layers, but the reflection models show detailed velocity changes within these layers. The models show the complexity of the structure of the oceanic crust and relate to regional geology. The crustal model of the Hudson '70 area shows thin sediments over the basement which consists of either two layers or a layer with a velocity gradient. The model compares well with the results obtained in the same area by Keen and Barrett (1971). The model for the region off Queen Charlotte Sound indicates six sedimentary layers of different velocities, basement at a depth of 2.4 km sub-bottom, and the oceanic layer at a depth of 4.5 km sub-bottom. Velocity reversals within the sediments possibly show the influence of Pleistocene glaciation on the deposition of sediments underneath the continental slope. The model for northern Cascadia Basin shows four layers within the sediments of thickness 1.9 km, a velocity transition between the sediments and the basement, the basement at a depth of 2.7 km sub-bottom, and the oceanic layer at a depth of 4.2 km sub-bottom. Proposed interbedding of volcanic material with high velocity sediments at the top of the basement correlates with geological formative processes observed at the crest of the near-by Juan de Fuca Ridge. The results have shown that the marine DSS system is an efficient technigue for detailed investigation of the oceanic crust and is an inexpensive alternative to the multichannel common depth point techniques used in the oil industry.
Reply: Beneficial effect of interleukin-2-based immunomodulation in Alzheimer-like pathology (2017)

International audience
Solid state polymerization of acrylamide initiated by gamma radiation (1960)

Abstract The solid‐state polymerization of acrylamide, both in a radiation field and after removal from the field, is shown to proceed by an unusual kinetic mechanism. The usual steady state assumption is found to be inadequate because there seems to be no free radical termination (in the normal sense) involved. These results are consistent with the view that the solid‐state polymerization proceeds by a nucleation mechanism in which the free radicals are probably trapped by overlapping of the reactive sites.
Adaptive Disturbance Tracking Control With Wind Speed Reduced Order State Estimation for Region II Control of Large Wind Turbines (2012)

In this paper we introduce an Adaptive Disturbance Tracking Control (ADTC) Theory and make some modifications to implement it to address Region II control problem of large wind turbines. Since ADTC requires measurement of wind speed, a wind speed and partial state estimator based on linearized lower-order model of wind turbine at Region II operating point was developed. The estimated wind speed was then used with the adaptive controller and the states were used for state feedback. The combination of partial state feedback and adaptive disturbance tracking control is implemented in National Renewable Energy Laboratory (NREL)’s 5 MW offshore wind turbine model and simulated in MATLAB/Simulink. The simulation result was then compared with existing fixed gain controller.
Studies on the Reaction of Chymotrypsin and L-1-Chloro-3-tosylamido-4-phenyl-2-butanone (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on the Reaction of Chymotrypsin and L-1-Chloro-3-tosylamido-4-phenyl-2-butanoneFerenc J. Kezdy, Alan. Thomson, and Myron L. BenderCite this: J. Am. Chem. Soc. 1967, 89, 4, 1004–1009Publication Date (Print):February 1, 1967Publication History Published online1 May 2002Published inissue 1 February 1967https://pubs.acs.org/doi/10.1021/ja00980a044https://doi.org/10.1021/ja00980a044research-articleACS PublicationsRequest reuse permissionsArticle Views63Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
AxGames (2016)

Approximate computing trades quality of application output for higher efficiency and performance. Approximation is useful only if its impact on application output quality is acceptable to the users. However, there is a lack of systematic solutions and studies that explore users' perspective on the effects of approximation. In this paper, we seek to provide one such solution for the developers to probe and discover the boundary of quality loss that most users will deem acceptable. We propose AxGames, a crowdsourced solution that enables developers to readily infer a statistical common ground from the general public through three entertaining games. The users engage in these games by betting on their opinion about the quality loss of the final output while the AxGames framework collects statistics about their perceptions. The framework then statistically analyzes the results to determine the acceptable levels of quality for a pair of (application, approximation technique). The three games are designed such that they effectively capture quality requirements with various tradeoffs and contexts. To evaluate AxGames, we examine seven diverse applications that produce user perceptible outputs and cover a wide range of domains, including image processing, optical character recognition, speech to text conversion, and audio processing. We recruit 700 participants/users through Amazon's Mechanical Turk to play the games that collect statistics about their perception on different levels of quality. Subsequently, the AxGames framework uses the Clopper-Pearson exact method, which computes a binomial proportion confidence interval, to analyze the collected statistics for each level of quality. Using this analysis, AxGames can statistically project the quality level that satisfies a given percentage of users. The developers can use these statistical projections to tune the level of approximation based on the user experience. We find that the level of acceptable quality loss significantly varies across applications. For instance, to satisfy 90% of users, the level of acceptable quality loss is 2% for one application (image processing) and 26% for another (audio processing). Moreover, the pattern with which the crowd responds to approximation takes significantly different shape and form depending on the class of applications. These results confirm the necessity of solutions that systematically explore the effect of approximation on the end user experience.
Timing of Surgery Following Spinal Cord Injury (2005)

Early surgical treatment is beneficial in terms of reducing complications, length of stay, and hospital costs. Further studies are needed to clearly demonstrate the impact of operative timing on neurological outcome.
Multiwedge array for uniform target irradiation (2000)

The effectiveness of multi-wedge plates array for the improvement of the laser irradiation uniformity on the pellet target in inertial confinement fusion has been investigated. A multi-wedge plates array of 90-mm in diameter was fabricated with wedge plates of 7 pairs, which ad a size of 30-mm diameter and a wedge angle of about 0.1 degrees. Also, to prevent the diffraction caused by each wedge plates, a soft aperture with the transmission profile of 16th super gaussian was designed and fabricated. As the result, it was confirmed that the array decreased the low- mode uniformity and is able to control the beam profile.
Scaling and Fluctuations of the Lyapunov Exponent in a 2D Anderson Localisation Problem (2003)

Here 〈. . .〉 represents a statistical average over realizations of the random potential. Expression (1) was first conjectured by Anderson et al. and later derived by many different authors within the framework of the random phase approximation. A correct and rigorous criterion for the validity of (1) was established only much later. For a sufficiently long 1D system the logarithm of the dimensionless conductance g is approximately
Biological Activities and Potential Therapeutic Uses of Steel Factor; A New Growth Factor Active on Multiple Hematopoietic Lineages (1992)

Recently, a novel growth factor has been cloned that has growth promoting activities on a wide variety of hematopoietic cell lineages. This factor has been referred to as mast cell growth factor, stem cell factor, or kit ligand, and will be referred to here as steel factor. Steel factor stimulates the growth of cells via its interaction with the c-kit proto-oncogene, which is a tyrosine kinase receptor that is expressed on the surface of a number of different cell types. In addition to its effects on hematopoiesis, this factor also plays a role in the development of melanocytes and germ cells. The discovery of this growth factor provided the final piece of the puzzle to explain the molecular defects associated with several well known genetic mutations in mice, and has opened the door to understanding the role of this factor in development. Similar genetic defects may exist in humans as well. The aim of this paper is to review the biological structure and activities of this new growth factor, and to discuss its potential applications in clinical medicine.
Color standards for electronic imaging (1991)

When I was asked to prepare this paper, my immediate response was that the topic was overwhelming. However, the more I thought about the issues the more I realized that because we understand so little about color and electronic imaging, I could get away with almost anything. I won’t take that much freedom.
Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways (2022)

Although glucagon secretion is perturbed in both T1D and T2D, the pathophysiological changes in individual pancreatic alpha cells are still obscure. Using recently curated single-cell RNASeq data from T1D or T2D donors and their controls, we identified alpha cell transcriptomic alterations consistent with both common and discrete pathways. Although alterations in alpha cell identity gene (ARX, MAFB) expression were conserved, cytokine-regulated genes and genes involved in glucagon biosynthesis and processing were up-regulated in T1D. Conversely, mitochondrial genes associated with ROS (COX7B, NQO2) were dysregulated in T2D. Additionally, T1D alpha cells displayed altered expression of autoimmune-induced ER stress genes (ERLEC1, HSP90), whilst those from T2D subjects showed modified glycolytic and citrate cycle gene (LDHA?, PDHB, PDK4) expression. Thus, despite conserved alterations related to loss of function, alpha cells display disease-specific gene signatures which may be secondary to the main pathogenic events in each disease, namely immune- or metabolism-mediated-stress, in T1D and T2D, respectively.
Cardiovascular Risks Associated with Patients Infected with Scrub Typhus: A Nationwide Cohort Study (2023)

Abstract Background Scrub typhus is an infectious disease that affects multiple organs. However, the long-term cardiovascular (CV) risk in survivors remains unknown. Method A retrospective cohort study used administrative claims data from the National Health Insurance Research Database (NHIRD) to investigate the CV risk of scrub typhus survivors from January 1, 2010, to December 31, 2015. People who had prior CV events before the diagnosis of scrub typhus were excluded. The CV outcomes of interest were acute myocardial infarction (AMI), heart failure hospitalization (HFH), hemorrhagic or ischemic stroke, new-onset atrial fibrillation (AF), aneurysm or dissection of aorta, venous thromboembolism (VTE), and CV death. Result A total of 2,269 patients with scrub typhus and without a prior CV event were identified (mean age 47.8±16.1 years, 38.0% female). The health control cohort (n=2,264) was selected to compare by the frequency matching with age, gender, and co-morbidities with patients with scrub typhus. The incidence of HFH, new-onset AF, and total events was significantly higher among patients with scrub typhus than the control cohort with an adjusted hazard ratio (aHR) of 1.97, 95% confidence interval (CI) 1.13-3.42 for HFH; 2.48, 95% CI: 1.23-5.0 for new-onset AF; 1.43, 95% CI: 1.08-1.91 for total CV events, respectively. The event rates of other outcomes were similar between the two groups. Conclusion In the cohort study, survivors of scrub typhus are at heightened risk of subsequent CV events, especially for HFH and new-onset AF. These findings serve as an important reminder to physicians regarding the significant CV risk that remains present following acute scrub typhus infection.
Maspin Is an Intracellular Serpin That Partitions into Secretory Vesicles and Is Present at the Cell Surface (1997)

The tumor suppressor maspin (mammary serpin) was originally identified as a component of human mammary epithelial cells that is downregulated as mammary tumor cells progress from the benign to the invasive and metastatic states. Maspin inhibits cellular invasion, motility, and proliferation, but its mechanism of action is currently unknown. Because the cellular machinery responsible for these processes is cytoplasmic, we have reexamined the tissue distribution and subcellular localization of maspin. We find that maspin, or a maspin-like protein, is present in many human organs, in which it localizes to epithelia. In cultured human mammary myoepithelial cells, maspin is predominantly a soluble cytoplasmic protein that associates with secretory vesicles and is present at the cell surface. In vitro assays show that the vesicle association is due to the existence of an uncleaved facultative secretion signal that allows small amounts of maspin to partition into the endoplasmic reticulum. These results demonstrate that maspin is more widespread than previously believed. The subcellular localization studies indicate that soluble intracellular and vesicle-associated maspin probably play an important role in controlling the invasion, motility, and proliferation of cells expressing it, whereas extracellular maspin may also regulate these processes in adjacent cells.
A discrete-choice experiment to assess patients’ preferences for osteoarthritis treatment: An ESCEO working group (2020)

This study suggests that all seven treatment attributes were important for OA patients. Overall, given the range of levels, the most important outcomes were impact on disease progression and improvement in pain and walking.