gebhart/patrepeval huggingface dataset:
Building a Domain Knowledge Base from Wikipedia: a Semi-supervised Approach (2016)

Knowledge bases are becoming indispensable to software engineering and knowledge engineering. However, the existing domain knowledge bases are always artificially constructed and small-scale. In this paper, we propose a semi-supervised approach to domain concepts detection and software engineering knowledge base construction from Wikipedia. First, the approach selects domain relevant tags from Stackoverflow. Then, it matches Wikipedia entities and expands the concept set through an improved label propagation algorithm. A rule-based method is designed to discover semantic relations including relate, subclassOf and equal by analyzing structural information of Wikipedia. A relation derivation mechanism is presented to optimize the relation set. We finally construct SEBase, a domainspecific knowledge base of software engineering. Experimental results show the high accuracy of the integrated concepts and relations. Compared with other knowledge bases, SEBase has the widest coverage of concepts and relations in software engineering.
Figure S3 from A Dual PI3K/HDAC Inhibitor Induces Immunogenic Ferroptosis to Potentiate Cancer Immune Checkpoint Therapy (2023)

&lt;p&gt;Transcriptional profiling, cell cycle arrest and apoptosis of BEBT-908 treated tumor cells.&lt;/p&gt;
Wild mice express an Ig V lambda gene that differs from any V lambda in BALB/c but resembles a human V lambda subgroup (1992)

The lambda L chain locus in the inbred mouse strains commonly used in the laboratory contains a limited number of germ-line genes; only three V lambda and three functional J lambda-C lambda genes have been identified in BALB/c mice. Previous studies indicated that wild mice may have a considerably expanded number of C lambda genes, as judged by the number of DNA restriction fragments that hybridize to C lambda probes derived from BALB/c. In order to evaluate the expression of these putative lambda genes, we have determined sequences of cDNA encoding lambda-chains in hybridomas from wild mice of the subspecies Mus musculus musculus from two different geographic regions, Denmark and Czechoslovakia. Two of these hybridomas produce L chains with J and C regions that are very similar to those of BALB/c lambda 1 chains, but the V regions of these L chains are only approximately 40% identical in amino acid sequence to the known murine V lambda. Indeed, these wild mouse V lambda are closer in sequence to human V lambda than they are to BALB/c V lambda, especially to human V lambda of subgroup VI, with which they share an unusual two-residue insertion in framework 3; L chains bearing V regions of this rare human type have a marked tendency to enter into amyloid deposits. These findings suggest that similar V lambda may be widespread in mammalian populations, although analysis by Southern blotting indicates that they are not found in BALB/c mice. A third hybridoma produces a L chain whose V lambda resembles BALB/c V lambda 1. The J lambda and C lambda segments of the cDNA encoding all three hybridoma L chains are identical; evidently, of the several putative genes that hybridize to C lambda 1 probes, one is expressed preferentially.
Large-area perovskite solar cells with CsxFA1−xPbI3−yBry thin films deposited by a vapor–solid reaction method (2018)

Large-area, highly uniform Cs<sub>x</sub>FA<sub>1−x</sub>PbI<sub>3−y</sub>Br<sub>y</sub> mixed cation perovskite films were prepared by a facile vapor–solid reaction method.
Flexing Muscle With Just One Amino Acid (1996)

A key player in muscle contraction is the protein troponin-C, whose contortions after binding calcium ions set off a cell's contraction. Now researchers have demonstrated that those contortions are produced by a single glutamic acid in the protein, which is attracted to the calcium and pulls part of the protein along with it. The result is the first to suggest that a large shape change in a protein can be controlled by just one amino acid.
Migraine Associated with Obstructive Sleep Apnea-A Nationwide Population-Based Study (2017)

背景：利用台灣健保資料庫的資料來分析偏頭痛與阻塞型睡眠呼吸中止症的關聯性。方法：針對年齡及性別使用傾向分數(propensity score matching)配對出1 : 4比例的阻塞型睡眠呼吸中止症組為4759名(經睡眠多項呼吸生理檢查確診)，非睡眠呼吸中止症組為19036名；之後再利用考克斯比例風險模式(The multivariate Cox proportional hazards model)來探討偏頭痛及阻塞型睡眠呼吸中止症之間的關係。結果：偏頭痛在阻塞型睡眠呼吸中止症組的盛行率為13.5%，非阻塞型睡眠呼吸中止症組的盛行率為10.4%，兩者在統計上有顯著差異(p ＜ 0.001)。考克斯比例風險模式顯示阻塞型睡眠呼吸中止症組中的病人相較非阻塞型睡眠呼吸中止症組更容易有偏頭痛(hazard ratio, 1.17; 95% CI, 1.06-1.28)(p = 0.001)。結論：本篇研究發現阻塞型睡眠呼吸中止症患者有較高的風險罹患偏頭痛。不過阻塞型睡眠呼吸中止症與偏頭痛在生理學上的關聯仍須進一步的研究探討。
Ultrasound-assisted synthesis of pyrimidines and their fused derivatives: A review (2021)

The pyrimidine scaffold is present in many bioactive drugs; therefore, efficient synthetic routes that provide shorter reaction times, higher yields, and site-selective reactions are constantly being sought. Ultrasound (US) irradiation has emerged as an alternative energy source in the synthesis of these heterocyclic scaffolds, and over the last ten years there has been a significant increase in the number of publications mentioning US in either the construction or derivatization of the pyrimidine core. This review presents a detailed summary (with 140 references) of the effects of US (synergic or not) on the construction and derivatization of the pyrimidine core through classical reactions (e.g., multicomponent, cyclocondensation, cycloaddition, and alkylation reactions). The main points that were taken into consideration are as follows: chemo- and regioselectivity issues, and the results of conventional heating methods compared to US and mechanistic insights that are also presented and discussed for key reactions.
Epidemiology of Cholera in Bangladesh: Findings From Nationwide Hospital-based Surveillance, 2014–2018 (2019)

Cholera occurs throughout a large part of Bangladesh. Cholera-prone areas should be prioritized to control the disease by implementation of targeted interventions. These findings can help strengthen the cholera-control program and serve as the basis for future studies for tracking the impact of cholera-control interventions in Bangladesh.
BMP-9 interferes with liver regeneration and promotes liver fibrosis (2017)

Constitutive expression of low levels of BMP-9 stabilises hepatocyte function in the healthy liver. Upon HSC activation, endogenous BMP-9 levels increase in vitro and in vivo and high levels of BMP-9 cause enhanced damage upon acute or chronic injury.
ASIS MDL: a Prototype Electronic Content Service (1998)

In this paper, we present our design and implementation of ASIS MDL, a prototype for electronic content service in an academic library environment. Besides bibliographic information, our service includes an archive of digital audio and video streams, CD titles, and WWW contents. This system not only aims at end customer supports, e.g., searching, streaming, and browsing operations, but it also facilitates admission control, content production, distribution processes, and license control, etc. We address several design issues, e.g., the need for accounting support, for integrating third party system components, and for a computer aided tool to automatically categorize WWW documents. Our solutions to these problems are presented. 1.
Asian Soybean Rust Resistance: An Overview (2015)

Asian soybean rust caused by Phakopsora pachyrhizi, occurs in all soybean production regions of the world. Rust is the most destructive foliar disease of soybean and can cause yield losses of over 80%. To date, six race-specific resistance genes have been identified in plant introductions. However, races of P. pachyrhizi able to overcome the resistance conferred by these genes have evolved. Due to the limited availability of resistant varieties, fungicide application is the only management tool available for farmers, which significantly raises the production cost and the risk of environmental and human contamination. Thus, the transfer of resistance genes through classical breeding followed by marker-assisted selection allows the development of resistant varieties and their use as an efficient and cost-effective method for controlling soybean rust. The objective of this review is to provide a broad overview of the Asian soybean rust resistance, and a useful tool to guide future researches as well.
Predicting Clinical Effects of CYP3A4 Modulators on Abemaciclib and Active Metabolites Exposure Using Physiologically Based Pharmacokinetic Modeling (2020)

Abemaciclib, a selective inhibitor of cyclin-dependent kinases 4 and 6, is metabolized mainly by cytochrome P450 (CYP)3A4. Clinical studies were performed to assess the impact of strong inhibitor (clarithromycin) and inducer (rifampin) on the exposure of abemaciclib and active metabolites. A physiologically based pharmacokinetic (PBPK) model incorporating the metabolites was developed to predict the effect of other strong and moderate CYP3A4 inhibitors and inducers. Clarithromycin increased the area under the plasma concentration-time curve (AUC) of abemaciclib and potency-adjusted unbound active species 3.4-fold and 2.5-fold, respectively. Rifampin decreased corresponding exposures 95% and 77%, respectively. These changes influenced the fraction metabolized via CYP3A4 in the model. An absolute bioavailability study informed the hepatic and gastric availability. In vitro data and a human radiolabel study determined the fraction and rate of formation of the active metabolites as well as absorption-related parameters. The predicted AUC ratios of potency-adjusted unbound active species with rifampin and clarithromycin were within 0.7- and 1.25-fold of those observed. The PBPK model predicted 3.78- and 7.15-fold increases in the AUC of the potency-adjusted unbound active species with strong CYP3A4 inhibitors itraconazole and ketoconazole, respectively; and 1.62- and 2.37-fold increases with the concomitant use of moderate CYP3A4 inhibitors verapamil and diltiazem, respectively. The model predicted modafinil, bosentan, and efavirenz would decrease the AUC of the potency-adjusted unbound active species by 29%, 42%, and 52%, respectively. The current PBPK model, which considers changes in unbound potency-adjusted active species, can be used to inform dosing recommendations when abemaciclib is coadministered with CYP3A4 perpetrators.
Characterization and Expression Profiling of Neuropeptides and G-Protein-Coupled Receptors (GPCRs) for Neuropeptides in the Asian Citrus Psyllid, Diaphorina citri (Hemiptera: Psyllidae) (2018)

Neuropeptides are endogenous active substances that widely exist in multicellular biological nerve tissue and participate in the function of the nervous system, and most of them act on neuropeptide receptors. In insects, neuropeptides and their receptors play important roles in controlling a multitude of physiological processes. In this project, we sequenced the transcriptome from twelve tissues of the Asian citrus psyllid, <i>Diaphorina citri</i> Kuwayama. A total of 40 candidate neuropeptide genes and 42 neuropeptide receptor genes were identified. Among the neuropeptide receptor genes, 35 of them belong to the A-family (or rhodopsin-like), four of them belong to the B-family (or secretin-like), and three of them are leucine-rich repeat-containing G-protein-coupled receptors. The expression profile of the 82 genes across developmental stages was determined by qRT-PCR. Our study provides the first investigation on the genes of neuropeptides and their receptors in <i>D. citri</i>, which may play key roles in regulating the physiology and behaviors of <i>D. citri</i>.
Materials issues involving austenitic pressure vessel internals arising from void swelling and irradiation creep (1994)

The austenitic stainless steels, primarily Types 304 and 316, that frame and support the core of typical light water reactors (LWRs) will reach end-of-life neutron exposures after 40 yr that are comparable to those received in only 2 yr of operation in typical liquid metal reactors (LMRs) such as the Experimental Breeder Reactor II (EBR-II) and Fast Flux Test Facility. These exposures will cause cumulative atomic displacement levels as high as 80 displacements per atom (dpa), especially in the baffle plate assemblies. Depending on the local coolant temperature, local power level, and the thickness of a given structural component, temperatures as high as 400{degrees}C can be reached as a consequence of the relatively high gamma heating rates in LWRs and the moderately low thermal conductivity of such steels. This report discusses the problem of void swelling in type 304L and 316 steels.
A dimming experiment on moving striations in 50Hz AC operated fluorescent lamp (2008)

Summary form only given. Moving striations in fluorescent lamp is a well-known phenomenon. AC operation and mixed filling-ins pose difficulties in understanding the physical reason and relative processes of moving striations. In this paper, an experiment is carried out in order to find out factors correlated to moving striations in fluorescent lamps. The basic experimental circuit consists of a 36 W T8 fluorescent lamp, a magnetic ballast and an ignitor. A photodiode is used to collect the light signal from the lamp. The circuit is supplied with 185 V 50 Hz AC and the lamp is kept on for long enough time so that temperature distribution on the tube is stable. The cold spot temperature (Tc) of the tube is about 40 centigrade. Then the lamp is quickly dimmed down (process "Dim Down") by decreasing the supply voltage until it reaches 150 V, the lowest limit for the working lamp. Immediately, the lamp is dimmed up the same way back (process "First Dim up"). Lamp current and light signals from the photodiode are taken during the process. The aim of quick dimming is that between two successive dimming, there is no enough time for total temperature relaxation on the tube. Thus, Tc and partial pressure of mercury will not change a lot. Next, we supply the circuit with 150 V 50 Hz AC for long enough time; and then quickly dim up the lamp until the supply voltage comes to 185 V (process "Second Dim up"). In this case, Tc is lower during the whole dimming process, since the lamp works under a lower voltage at first, where the correspondent Tc is about 34 centigrade. Experimental results show that amplitude of moving striations in First Dim up is much lower than that in the case of Second Dim up. Kajiwara has revealed close relationship between Tc and moving striations in a low frequency fluorescent lamp. Therefore, the big difference in relative amplitude of moving striations between First Dim up and Second Dim up can come from the difference in Tc. Compared to Second Dim up, amplitude of striations in First Dim up is much closer to that of Dim Down. That is due to the smaller difference in cold spot temperature in the two cases. In conclusion, moving striations in fluorescent lamp have close relationship with cold spot temperature of the tube. The lower Tc is, the stronger the moving striation is.
The Effect of Laser Beam Intensity and Microscope Illumination Intensity, on the Response of Electrostatic Resonators (2020)

In this work we measure the response of an electrostatic MEMS resonator that is made from single-crystalline silicon. Our setup allows for simultaneous measurement of the resonator motion, using both capacitive sensing and optical sensing with a laser vibrometer. We demonstrate that both vibrometer laser illumination and microscope illumination, can affect the resonance frequency of the resonator. Furthermore, we demonstrate that this thermal effect may be non-monotonic. We demonstrate that for low levels of illumination power, the resonance frequency first increases, but then resonance frequency decreases when the illumination power is further increased. This peculiar response is attributed to the competing effects of prestress, and of thermal stress that is induced by illumination. We demonstrate that the measurement of device resistance is a good indicator of thermal heating.
Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis (2019)

Our data suggest that iRhom2 is a negative regulator of thermogenesis and plays a role in the control of adipose tissue homeostasis during metabolic disease.
Deafened People: Adjustment and Support (2000)

It is estimated that there are currently 1.9 million deafened people living in North America - individuals who could once hear naturally or with amplification but have become deaf and are now unable to rely on hearing to comprehend spoken information. Despite this vast number, until now there have been few books that specifically address the process of adjustment to, and acceptance of, deafness as an adult. Kathryn Woodcock and Miguel Aguayo have addressed that situation with their unique look at deafness in Deafened People: Adjustment and Support.The authors demonstrate that deafness is not merely a medical condition; it is a social disability that affects the individual, the family, the social circle, and the work group. By describing the psychosocial experience of acquired deafness as a process of adjustment, Woodcock and Aguayo demonstrate that acceptance of deafness is a process involving practical, social, and emotional implications. To assist in that process, the authors have provided a guide to self-help techniques of proven value to deafened people.Drawing on their own experiences as deaf professionals, Woodcock and Aguayo explore such questions as how deafness occurs, how relationships (professional and personal) can be affected by progressive deafness, and how and where to find peer support. Section 1 describes the process of adjustment, while section 2 offers a practical guide to a successful method of establishing a self-help support network, with reference to such organizations as the Association of Late-Deafened Adults. Written in a lively, engaging style, the book combines medical background, professional advice, information on resources, and personal examples. Deafened People: Adjustment and Support will be invaluable for medical professionals and lay readers alike
Distinct osmo‐sensing protein kinase pathways are involved in signalling moderate and severe hyper‐osmotic stress (1999)

Plant growth is severely affected by hyper-osmotic salt conditions. Although a number of salt-induced genes have been isolated, the sensing and signal transduction of salt stress is little understood. We provide evidence that alfalfa cells have two osmo-sensing protein kinase pathways that are able to distinguish between moderate and extreme hyper-osmotic conditions. A 46 kDa protein kinase was found to be activated by elevated salt concentrations (above 125 mM NaCl). In contrast, at high salt concentrations (above 750 mM NaCl), a 38 kDa protein kinase, but not the 46 kDa kinase, became activated. By biochemical and immunological analysis, the 46 kDa kinase was identified as SIMK, a member of the family of MAPKs (mitogen-activated protein kinases). SIMK is not only activated by NaCl, but also by KCl and sorbitol, indicating that the SIMK pathway is involved in mediating general hyper-osmotic conditions. Salt stress induces rapid but transient activation of SIMK, showing maximal activity between 8 and 16 min before slow inactivation. When inactive, most mammalian and yeast MAPKs are cytoplasmic but undergo nuclear transloca- tion upon activation. By contrast, SIMK was found to be a constitutively nuclear protein and the activity of the kinase was not correlated with changes in its intra-cellular compartmentation, suggesting an intra-nuclear mechanism for the regulation of SIMK activity.
An integrated approach to understand biological stress system dysregulation across depressive and anxiety disorders (2021)

Affective disorders involve dysregulation of major biological stress systems (hypothalamic-pituitary-adrenal (HPA)-axis, immune system, autonomic nervous system (ANS)). Suchdysregulationshave rarely beensimultaneously examined across different stress systems. In the Netherlands Study of Depression and Anxiety (n=2789), we investigated whether current or remitted depressive and/or anxiety disorders (based on the CIDI semi-structured interview), including specific symptom profiles, were associated with separate markers and cumulative indexes of the HPA-axis (cortisol awakening response, evening cortisol, dexamethasone suppression test cortisol), immune system (C-reactive protein, interleukin-6, tumor necrosis factor-α), and ANS (heart rate, respiratory sinus arrhythmia, pre-ejection period). Depressive andanxiety disorderswere significantlyassociated with changes in three biological stress systemsincluding HPA-axis hyperactivity, increased inflammatory activity, and a higher ANS tone, particularly for integrative and cumulative indexes of these stress systems (pFDR <.05) vs. controls. The strongest associations were seen with current disorders andcumulative indexes of the HPA-axis (β=.124, pFDR=.001), the immune system (β =.057, pFDR=.032), and total cumulative index across stress systems (β=.102, pFDR=.004). Atypical, energy-related depression severity was linked to immune system markers (pFDR<0.001), melancholic depression severity to HPA-axis markers (pFDR=.032), and anxiety arousal severity to both HPA-axis and immune system markers (pFDR<0.05). Findings were partially explained by poorer lifestyle, more chronic diseases,or (especially for ANS-function) antidepressant use. Cross-sectional analyses limit examination of temporal associations. Patients withdepressive and anxiety disorders showed consistent dysregulation across biological stress systems, particularly for current episodes.To understand stress system functionality in affective disorders, an integrated approach capturing cumulative stress indices within and across biological stress systems is important.
Agriculture et numérique - Livre Blanc INRIA- INRAE : Tirer le meilleur du numérique pour contribuer à la transition vers des agricultures et des systèmes alimentaires durables (2022)

Illustration de couverture : © Smart Farm by SBTS from NounProject.com <br/>Illustration de couverture : © Smart Farm by SBTS from NounProject.com
Control of Circadian Rhythms and Photoperiodic Flowering by the Arabidopsis GIGANTEA Gene (1999)

Photoperiodic responses in plants include flowering that is day-length-dependent. Mutations in the Arabidopsis thaliana GIGANTEA (GI) gene cause photoperiod-insensitive flowering and alteration of circadian rhythms. The GI gene encodes a protein containing six putative transmembrane domains. Circadian expression patterns of the GI gene and the clock-associated genes, LHY and CCA1, are altered in gi mutants, showing that GI is required for maintaining circadian amplitude and appropriate period length of these genes. The gi-1 mutation also affects light signaling to the clock, which suggests that GI participates in a feedback loop of the plant circadian system.
Ascorbic Acid Levels in Critically-Ill Children and the Impact of Nutrition (2021)

Background: Critically-ill adults with sepsis and ARDS are known to have low ascorbic acid (AscA) levels. Recent studies suggest improved organ function, decreased vasopressor use, and decreased mortality in adult ICU patients following AscA supplementation. To date there are no studies that describe the impact of pediatric critical illness and nutrition on AscA levels. Objective: The primary aim of this study was to describe AscA levels in critically-ill pediatric patients. Our secondary aims were to associate AscA levels with disease severity and clinical outcomes as well as explore the influence …
Correction: Substrate-specifying determinants of the nucleotide pyrophosphatases/phosphodiesterases NPP1 and NPP2 (2017)

Biochem. J. 2004, volume 381, issue 1, pages 71–77, https://doi.org/10.1042/BJ20040465In the preparation of Figures 6A and 7A, a transcriptional error occurred which has resulted in duplication of some lanes.The original scans of the gels used to prepare Figures 6A and 7A are presented here.The authors apologise for this error and note that the duplications did not affect in any way the description and interpretation of the data. They apologize for any misunderstanding or confusion caused.