gebhart/patrepeval huggingface dataset:
Expression analysis of inflammasome sensors and implication of NLRP12 inflammasome in prostate cancer (2017)

Inflammasomes are multi-proteins complex regulating inflammation-associated signaling. While inflammation plays a critical role in cancer cell growth, studies remain uncharacterized on the role of inflammasomes in prostate cancer. Using Gene Expression Omnibus (GEO) public datasets, we screened the expression profiles of inflammasome sensors NLRP3, NLRC4, NLRP6, NRLP12, and AIM2 in prostate tumor tissues, and verified their mRNA level in a panel of prostate cancer cell lines. The selected expression of NLRP3 and NLRP12 inflammasomes was validated, and the clinical association was evaluated in human prostate archival tumor tissues. We observed that the expression of inflammasome sensors was dysregulated at the mRNA level except for the NLRP12. The intensity of NLRP12 immunostaining was significantly higher in malignant prostate as compared to their adjacent benign tissues. In contrast, the NLRP3 immunostaining in prostate tissues was heterogeneous. The inflammasome complex proteins ASC (apoptosis-associated speck-like protein containing a CARD) and pro-caspase-1, as well as its downstream targets IL-1β and IL-18 were confined to aggressive prostate cancer cells. These data suggest an increased expression of NLRP12 in association with prostate cancer and support the role of NLRP12 inflammasome complex regulating inflammatory cytokines in understanding the role of inflammation in the prostate cancer.
Prophylaxis of mammary neoplasia by selenium supplementation in the initiation and promotion phases of chemical carcinogenesis. (1981)

The present study was designed to determine the chemopreventive effect of dietary selenium supplementation in the initiation or promotion phase of 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in rats fed a high-fat diet. Control animals received 0.1 ppm of selenium (as sodium selenite), while experimental groups were supplemented with 5 ppm of selenium for various periods of time: -2 to +24, -2 to +2, +2 to +24, +2 to +12, +12 to +24, and -2 to +12. The time of 7,12-dimethylbenz[a]anthracene administration (50 days of age) was taken as Time 0; minus and plus signs represent the time in weeks before and after 7,12-dimethylbenz[a]anthracene administration, respectively. The following conclusions were drawn from the results: (a) selenium can inhibit both the initiation and promotion phases of carcinogenesis; (b) a continuous intake of selenium is necessary to achieve maximal inhibition of tumorigenesis; (c) the inhibitory effect of selenium in the early promotion phase is probably reversible; and (d) the efficacy of selenium is attenuated when it is given long after carcinogenic injury. In addition, the present investigation also assessed the effectiveness of selenium in inhibiting the reappearance of mammary tumors that had regressed after ovariectomy. By supplementing tumor-bearing animals with 5 ppm of selenium in the diet immediately after endocrine ablation, it was found that tumors reappeared at a slower rate compared to the controls. The data suggested that selenium is not only effective in chemoprevention but can also be used as an adjuvant chemotherapeutic agent.
Post Extracorporeal Membrane Oxygenation Single Photon Emission Computed Tomography (SPECT) as a Predictor of Neurodevelopmental Outcome (1994)

Although a normal SPECT scan was more likely to predict a normal neurodevelopmental outcome, an abnormal SPECT scan did not predict an abnormal outcome in these infants.
The saturation magnetostriction of permalloy films (1981)

The saturation magnetostriction of permalloy films has been measured as a function of film composition. In general, the data obtained agrees with the published values for bulk polycrystalline permalloy. It has further been established that the composition for zero magnetostriction is at about 81.5 (wt.)% Ni. The exact composition for 0 magnetostriction is difficult to attain and for most films deposited under practical conditions the magnetostriction is small but slightly negative or positive. Various elements such as Cr, Rh, Ir and Ti have been added to permalloy films to enhance their corrosion resistance. The saturation magnetostriction of these films has been measured as a function of the amount of dilutent. All of the dilutents cause positive contributions to the saturation magnetostriction of permalloy films; Ir has the largest effect on λ, with the other elements Ti, Cr and Rh the effect on λ is less than Ir and decreases in that order.
Dissecting whole-brain conduction delays through MRI microstructural measures (2021)

Network models based on structural connectivity have been increasingly used as the blueprint for large-scale simulations of the human brain. As the nodes of this network are distributed through the cortex and interconnected by white matter pathways with different characteristics, modeling the associated conduction delays becomes important. The goal of this study is to estimate and characterize these delays directly from the brain structure. To achieve this, we leveraged microstructural measures from a combination of advanced magnetic resonance imaging acquisitions and computed the main determinants of conduction velocity, namely axonal diameter and myelin content. Using the model proposed by Rushton, we used these measures to calculate the conduction velocity and estimated the associated delays using tractography. We observed that both the axonal diameter and conduction velocity distributions presented a rather constant trend across different connection lengths, with resulting delays that scale linearly with the connection length. Relying on insights from graph theory and Kuramoto simulations, our results support the approximation of constant conduction velocity but also show path- and region-specific differences.
Apolipoprotein A-I (ApoA-I), Immunity, Inflammation and Cancer (2019)

Apolipoprotein A-I (ApoA-I), the major protein component of high-density lipoproteins (HDL) is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune response regulation. Many studies revealing alterations of ApoA-I during the development and progression of various types of cancer suggest that serum ApoA-I levels may represent a useful biomarker contributing to better estimation of cancer risk, early cancer diagnosis, follow up, and prognosis stratification of cancer patients. In addition, recent in vitro and animal studies disclose a more direct, tumor suppressive role of ApoA-I in cancer pathogenesis, which involves anti-inflammatory and immune-modulatory mechanisms. Herein, we review recent epidemiologic, clinicopathologic, and mechanistic studies investigating the role of ApoA-I in cancer biology, which suggest that enhancing the tumor suppressive activity of ApoA-I may contribute to better cancer prevention and treatment.
Design and Implementation of a Distributed Cooperative Intrusion Detection System (2001)

An integrative taxonomy for intrusion detection technologies is proposed in this paper, which can specify accurately existing intrusion detection methods. Aiming at multiple domain environments, a distributed cooperative intrusion detection system (DCIDS) is designed, which implements cooperative intrusion detection through efficient, secure information exchange among IDSes in different domain. The architecture of DCIDS is described, as well as its four components: sensor, analyzer, manager and user interface. Some key issues are also discussed, including secure communication and selection of detection places.
Efficient simulation for large scale transistor level electrostatic discharge analysis and simulation (2016)

Electrostatic Discharge (ESD) has become an important reliability problem of today's semiconductor design. As a result of chip complexity and process scaling, higher resistance in power and ground nets along with increased device density have made ESD protection circuit design and verification quite critical for the proper chip operation over the time. An efficient simulation method coupled with the high capacity linear equations solver has been developed for ESD analysis of extremely large scale processor design. The method has been applied to the power grid meshes of various size and complexity, consistently achieved up to 5X run time improvement over the traditional Spice simulation with accuracy contained below 0.5%.
Anti-Aliasing through the Use of Coordinate Transformations (1982)

The use of the perpendicular point-line distance in evaluating the two-dimensional anti-aliasing convolution is studied. Transformations of the point-spread function (PSF) that give the effective convolution in terms of the point-line distance when the class of object space primitives is limited to lines and polygons are derived. Because the quality of filtering is embedded in a table indexed by the point-line distance, this approach allows one to use arbitrarily complex PSFs; only the width and not the shape of the PSF affects the amount of computation. The CORDIC algorithm is applied to point-line distance evaluation, and its merits are shown. Also shown are the more standard uses of the CORDIC algorithm for coordinate rotation, for polar-to-rectangular and rectangular-to-polar conversion, and for calculating the Euclidean norm of a vector. Rounded endpoints can be achieved by using the point-segment distance, and computational methods are given, including CORDIC implementation. The CORDIC algorithms for the aforementioned geometric operations are prime candidates for VLSI implementation because of their inherent parallel/pipeline nature.
Development of environmental barrier coatings for non-oxide ceramics (2023)

This review article outlines the authors’ previous works on environmental barrier coatings (EBC) for non-oxide ceramics and discusses what has been revealed since then. It also provides an overview of the research on eutectic coatings as EBC's that has been carried out in recent years. The authors have developed EBC for Lu 2 O 3 -doped silicon nitride ceramics. Since preliminary material screening tests revealed that Lu 2 Si 2 O 7 phase has superior resistance against water vapour corrosion, the development was carried out mainly on EBC's based on this phase. This review addresses recession behaviours in static state and dynamic steam jet water vapour environments for some oxides, as well as under steam jet test for silicon nitride ceramics with EBC's, in addition to fabrication of EBC's with oxides eutectic structure. One example of the authors’ works is described here, since it can fabricate a crack-free Al 2 O 3 –HfO 2 eutectic coating.
The HARMONI/ELT spectrographs (2018)

HARMONI is an Integral Field Spectrograph (IFS) for ESO’s ELT. It has been selected as the first light spec- trograph and will provide the workhorse spectroscopic capabilities for the ELT for many years. HARMONI is currently at the PDR-level and the current design for the HARMONI IFS consists of a number of spaxel scales sampling down to the diffraction limit of the telescope. It uses a field splitter and image slicer to divide the field into 4 sub-units, each providing an input slit to one of four nearly identical spectrographs. All spectrographs will operate at near infrared wavelengths (0.81-2.45 micrometers), sampling different parts of the spectrum with a range of spectral resolving powers (3300, 7000, 18000). In addition, two of the four spectrographs will have a Visible capability (0.5-0.83 micrometers) operating with seeing-limited observations. This proceeding presents an overview of the opto-mechanical design and specifications of the spectrograph units for HARMONI.
Algebraic Identities for Program Calculation (1989)

To calculate a program means to derive it from a suitable specification by a process of equational reasoning. We describe a number of basic algebraic identities that turn out to be extremely useful in this task. These identities express relationship between the higher-order functions commonly encountered in functional programming. The idea of program calculation is illustrated with two non-trivial examples.
Interactions between wild oat and a weed-competitive and non-competitive wheat cultivar as influenced by arbuscular mycorrhizal fungi (2001)

The response of a weed-competitive (Columbus) and non-competitive (Oslo) wheat (Triticum aestivum L.) cultivar, alone and in competition with wild oat (Avena fatua L.) to arbuscular mycorrhizal fungi (AMF) was assessed in a greenhouse study using four AMF species. Plants were inoculated with 300 spores of Glomus clarum, G. etunicatum, G. intraradices or G. mosseae and grown for 77 d in field soil containing low levels of indigenous AMF populations. The AMF species had no significant (P&lt;0.05) effect on the shoot fresh or dry weight of single stands of Oslo or Columbus compared to the uninoculated controls. However, G. etunicatum significantly (P&lt;0.05) enhanced the shoot fresh weight of single stands of wild oat, and G.&#13;\nintraradices significantly (P&lt;0.05) increased the shoot fresh and dry weight of wild oat compared to the uninoculated control. The competitiveness of wild oat in competition with Oslo was significantly (P&lt;0.05) enhanced by inoculation with G. mosseae, whereas the other AMF species had no effect. In contrast, inoculation of Oslo with G. clarum significantly (P&lt;0.05) increased the ability of Oslo to withstand wild oat competition. On the other hand, there were no differences in the ability of any of the AMF species to impact on wild oat growth in competition with Columbus. However, G. intraradices significantly (P&lt;0.05) increased the shoot dry weight of Columbus in competition with wild oat. These preliminary results indicate that different AMF species interact differently with various hosts, and that these interactions may be specific. In addition, it is apparent that these specific interactions may enhance the competitiveness of a non-competitive host against weeds.
Enzymatic Site‐Specific Functionalization of Protein Methyltransferase Substrates with Alkynes for Click Labeling (2010)

Pass and click: Protein methylation is an important posttranslational modification. Because the methyl group is a poor reporter group, new methods are needed to analyze methyltransferase substrates. A S-adenosyl-L-methionine-based cofactor was synthesized and used for the site-specific functionalization of proteins with alkynes by methyltransferases (first step) and subsequent labeling through CuAAC click chemistry (second step; see scheme).
Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations (2019)

Abstract Diazomethane is one of the most versatile reagents in organic synthesis, but its utility is limited by its hazardous nature. Although alternative methods exist to perform the unique chemistry of diazomethane, these suffer from diminished reactivity and/or correspondingly harsher conditions. Herein, we describe the repurposing of imidazotetrazines (such as temozolomide, TMZ, the standard of care for glioblastoma) for use as synthetic precursors of alkyl diazonium reagents. TMZ was employed to conduct esterifications and metal‐catalyzed cyclopropanations, and results show that methyl ester formation from a wide variety of substrates is especially efficient and operationally simple. TMZ is a commercially available solid that is non‐explosive and non‐toxic, and should find broad utility as a replacement for diazomethane.
Human Papillomavirus Prevalence and Type Distribution in 3603 HIV-Positive and HIV-Negative Women in the General Population of Tanzania (2011)

The HPV type distribution is similar in HIV-positive and HIV-negative women. These results suggest that the HPV vaccines that are currently available could protect women from HPV infection independently of their HIV status.
Cyclometalation of the platinum metals with nitrogen and alkyl, alkenyl, and benzyl carbon donors (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleCyclometalation of the platinum metals with nitrogen and alkyl, alkenyl, and benzyl carbon donorsGeorge R. Newkome, Wallace E. Puckett, Vinod K. Gupta, and Garry E. KieferCite this: Chem. Rev. 1986, 86, 2, 451–489Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/cr00072a006https://doi.org/10.1021/cr00072a006research-articleACS PublicationsRequest reuse permissionsArticle Views1379Altmetric-Citations383LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma (2016)

Adoptive transfer of chimeric antigen receptor-transduced T cells is a promising strategy for cancer immunotherapy. The CD38 molecule, with its high expression on multiple myeloma cells, appears a suitable target for antibody therapy. Prompted by this, we used three different CD38 antibody sequences to generate second-generation retroviral CD38-chimeric antigen receptor constructs with which we transduced T cells from healthy donors and multiple myeloma patients. We then evaluated the preclinical efficacy and safety of the transduced T cells. Irrespective of the donor and antibody sequence, CD38-chimeric antigen receptor-transduced T cells proliferated, produced inflammatory cytokines and effectively lysed malignant cell lines and primary malignant cells from patients with acute myeloid leukemia and multi-drug resistant multiple myeloma in a cell-dose, and CD38-dependent manner, despite becoming CD38-negative during culture. CD38-chimeric antigen receptor-transduced T cells also displayed significant anti-tumor effects in a xenotransplant model, in which multiple myeloma tumors were grown in a human bone marrow-like microenvironment. CD38-chimeric antigen receptor-transduced T cells also appeared to lyse the CD38(+) fractions of CD34(+) hematopoietic progenitor cells, monocytes, natural killer cells, and to a lesser extent T and B cells but did not inhibit the outgrowth of progenitor cells into various myeloid lineages and, furthermore, were effectively controllable with a caspase-9-based suicide gene. These results signify the potential importance of CD38-chimeric antigen receptor-transduced T cells as therapeutic tools for CD38(+) malignancies and warrant further efforts to diminish the undesired effects of this immunotherapy using appropriate strategies.
GaAs MESFET linear amplifiers (1975)

RESULTS OBTAINED on microwave linear amplifiers using GaAs Schottky MESFETs will be discussed in this paper. Under common source class A operating conditions, 3-cell MESFETs have delivered output powers as high as 670 mW at 1-dB gain compression at 4 GHz with 35% power added efficiency as follows: [q = (Pout-Pin) /Pdc]. With a 2-cell MESFET, 295 mW was obtained at a -20-dB third-order intermodulation level at 4 GHz under two-carrier operation with 22% efficiency. At 9 GHz, a linear gain of 5.2 dB, an output powero f 300 mW a t 1-dB gain compression and 21% power addeedf ficiency has been achieved. Results on power output, efficiency, third-order intermodulation and AM/PM conversion at G and H bands will be presented.
Evolving from Planning and Scheduling to Real-Time Operations Support: Design Challenges (2010)

Versions of Scheduling and Planning Interface for Exploration (SPIFe) have supported a variety of mission operations across NASA. This software tool has evolved and matured over several years, assisting planners who develop intricate schedules. While initially conceived for surface Mars missions, SPIFe has been deployed in other domains, where people rather than robotic explorers, execute plans. As a result, a diverse set of end-users has compelled growth in a new direction: supporting real-time operations. This paper describes the new needs and challenges that accompany this development. Among the key features that have been built for SPIFe are current time indicators integrated into the interface and timeline, as well as other plan attributes that enable execution of scheduled activities. Field tests include mission support for the Lunar CRater Observation and Sensing Satellite (LCROSS), NASA Extreme Environment Mission Operations (NEEMO) and Desert Research and Technology Studies (DRATS) campaigns.
A short synthesis of the 4-demethoxy-11-deoxyanthracycline skeleton. Regiospecific enolate C-carboxylation with carbon oxysulfide (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA short synthesis of the 4-demethoxy-11-deoxyanthracycline skeleton. Regiospecific enolate C-carboxylation with carbon oxysulfideE. Vedejs and B. NaderCite this: J. Org. Chem. 1982, 47, 16, 3193–3195Publication Date (Print):July 1, 1982Publication History Published online1 May 2002Published inissue 1 July 1982https://pubs.acs.org/doi/10.1021/jo00137a041https://doi.org/10.1021/jo00137a041research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Some Applications of the Grignard Cross‐Coupling Reaction in the Industrial Field. (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.