gebhart/patrepeval huggingface dataset:
Anti-inflammatory Role of GM1 and Other Gangliosides on Microglia (2021)

Abstract BackgroundGangliosides are glycosphingolipids highly enriched in the brain, with important roles in cell signaling, cell-to-cell communication, and immunomodulation. Genetic defects in the ganglioside biosynthetic pathway result in severe neurodegenerative diseases, while a partial decrease in the levels of specific gangliosides was reported in Parkinson’s disease and Huntington’s disease. In models of both diseases and other conditions, administration of GM1 - one of the most abundant gangliosides in the brain – provides neuroprotection. Most studies have focused on the direct neuroprotective effects of gangliosides on neurons, but their role in other brain cells, in particular microglia, is not known. In this study we investigated the effects of exogenous ganglioside administration and modulation of endogenous ganglioside levels on the response of microglia to inflammatory stimuli, which often contributes to initiation or exacerbation of neurodegeneration.Methods In vitro studies were performed using BV2 cells, mouse, rat, and human primary microglia cultures. Modulation of microglial ganglioside levels was achieved by administration of exogenous gangliosides, or by treatment with GENZ-123346 and L- t -PDMP, an inhibitor and activator of glycolipid biosynthesis, respectively. Response of microglia to inflammatory stimuli (LPS, IL-1b, phagocytosis of latex beads) was measured by analysis of gene expression and/or secretion of pro-inflammatory cytokines. The effects of GM1 administration on microglia activation were also assessed in vivo in C57Bl/6 mice, following intraperitoneal injection of LPS.ResultsGM1 decreased inflammatory microglia responses in vitro and in vivo , even when administered after microglia activation. These anti-inflammatory effects depended on the presence of the sialic acid residue in the GM1 glycan headgroup and the presence of a lipid tail. Other gangliosides shared similar anti-inflammatory effects in in vitro models, including GD3, GD1a, GD1b, and GT1b. Conversely, GM3 and GQ1b displayed pro-inflammatory activity. The anti-inflammatory effects of GM1 and other gangliosides were partially reproduced by increasing endogenous ganglioside levels with L- t -PDMP, whereas inhibition of glycolipid biosynthesis exacerbated microglial activation in response to LPS stimulation.ConclusionsOur data suggest that gangliosides are important modulators of microglia inflammatory responses and reveal that administration of GM1 and other complex gangliosides exerts anti-inflammatory effects on microglia that could be exploited therapeutically.
Palatally impacted canines: the double traction technique. (2007)

When closed eruption is used to recover palatally impacted canines, patients risk a second surgical operation because the traction attachment could come off or the wire ligature, which is connected to the attachment, could break. In order to reduce this risk, a new simple technique has been developed. Instead of the classic single one, two attachments are bonded to the impacted canine. During the orthodontic finishing, the technique includes a mandibular premolar bracket bonded to the ectopic canine. This device should produce a more negative torque (Torque -17 degrees rather than -7 degrees) over the root, which usually remains in palatal position soon after the performed crown recovery.
Serum IgE cross‐reactivity between fish and chicken meats in dogs (2018)

Whether any of these newly identified IgE cross-reactive chicken-fish allergens is the cause of clinical allergy needs to be determined in dogs reacting to at least two of these common food sources.
Certificate-based Access Control in Pure P2P Networks (2006)

Pure peer-to-peer (P2P) networks are characterized as being extremely decentralized and self-organized, properties which are essential in a number of environments, including teamwork, collaborative, and ad-hoc systems. One of the features offered by P2P networks is the possibility of having several replicas of the same content distributed among multiple nodes. Despite its advantages (e.g. robustness and fault tolerance), it is crucial to guarantee content authenticity, as well as to enforce appropriate access control policies. However, the extremely decentralized nature of these environments makes impossible to apply classic solutions that rely on some kind of fixed infrastructure, typically in the form of on-line trusted third parties. In a previous work, we presented a protocol for content authentication based on public key certificates that does not rely on the existence of a public key infrastructure. In this paper, we show how these certificates can be extended to provide authorization capabilities. In our scheme, each peer classifies her contents according to several security labels. Peers allowed to access a given content must have a security clearance of at least the same level that the content's. These security clearances, which take the form of attributes in public key certificates, can be discretionally issued by the content provider
Control System for Tractor-Platooning (2007)

A control system for two-tractor platooning was developed, which dealt with follow-up motions for both straight and curvous courses. Firstly, a trajectory of the leading tractor was dynamically obtained by processing the position points of the leading tractor with the method of least squares and curve fitting. Secondly, based on the vehicle kinematic model, a reference course for the following tractor was dynamically created from the trajectory of the leading tractor with a given lateral offset. Finally, an optimal path-tracking controller was designed to guide the following tractor along the reference course. Field tests were conducted on a flat meadow. The test results indicated that the following tractor followed up the leading tractor successfully. The mean and RMS lateral deviations for the straight course were 0.02 and 0.02 m, respectively, whereas those for the sinusoidal course were 0.02 and 0.04 m, respectively.
Designing Robots for the Battlefield: State of the Art (2021)

Abstract There is currently a global arms race for the development of artificial intelligence (AI) and unmanned robotic systems that are empowered by AI (AI-robots). This paper examines the current use of AI-robots on the battlefield and offers a framework for understanding AI and AI-robots. It examines the limitations and risks of AI-robots on the battlefield and posits the future direction of battlefield AI-robots. It then presents research performed at the Johns Hopkins University Applied Physics Laboratory (JHU/APL) related to the development, testing, and control of AI-robots, as well as JHU/APL work on human trust of autonomy and developing self-regulating and ethical robotic systems. Finally, it examines multiple possible future paths for the relationship between humans and AI-robots.
Clicked dipicolinic antennae for lanthanide luminescent probes (2010)

4-Triazolyl-dipicolinic acids, prepared efficiently by CuAAC, proved to act as efficient antennae for optical lanthanide probes containing Eu(3+) or Tb(3+), under linear and non linear excitations (one, two and three photons provided by laser induced luminescence). The versatility offered by the substitution of the triazole subunit is, in addition, useful for covalent linkage to slide glass providing luminescent films.
Achieving human-agent teamwork in eHealth based pervasive intelligent environments (2010)

Pervasive intelligent environments, such as digital homes, offer huge potentials for eHealth services. However, there is a question as to how best to manage (i.e. configure and program) these systems. The majority of solutions to-date rely exclusively on either end users or autonomous agents to mana
Comparison of Probabilistic-D and k-Means Clustering in Segment Profiles for B2B Markets (2011)

Customer segmentation is a critical business analysis tool that allows organizations to build customer profiles and plan marketing efforts to satisfy the varying demands of different segments. The objective of the present study is to empirically explore the concept of probabilistic-D clustering for segment profiling in a business-to-business (B2B) market. A SAS® macro that can be used on any data set for application of this technique is developed and reported. To the best of our knowledge, probabilistic-D technique has never been empirically tested in a business environment. It was compared with the widely used k- means clustering technique. Findings indicate a better explanation of customer segment profiles using probabilistic-D clustering because k-means seems to force a high percent of observations in segments where cluster membership probabilities are less than 50% as calculated by probabilistic-D clustering macro. These observations are likely to be non-responsive (or less responsive) to the marketing efforts directed towards respective k-means segments. Using a probabilistic-D clustering approach these observations can be targeted differently to improve the effectiveness of marketing communication and promotions.
Corrigendum to “Magnetic-field-synchronized wireless modulation of neural activity by magnetoelectric nanoparticles” [Brain Stimulat. 15/6 (2022) 1451–1462] (2023)

The authors regret a spelling mistake in Table 1 of this article. “MENP (11s Stim; n = 321)” should read “MENP (11s Stim; n = 130)”. The authors would like to apologise for any inconvenience caused. Magnetic-field-synchronized wireless modulation of neural activity by magnetoelectric nanoparticlesBrain Stimulation: Basic, Translational, and Clinical Research in NeuromodulationVol. 15Issue 6PreviewThe in vitro study demonstrates wirelessly controlled modulation of neural activity using magnetoelectric nanoparticles (MENPs), synchronized to magnetic field application with a sub-25-msec temporal response. Herein, MENPs are sub-30-nm CoFe2O4@BaTiO3 core-shell nanostructures. MENPs were added to E18 rat hippocampal cell cultures (0.5 μg of MENPs per 100,000 neurons) tagged with fluorescent Ca2+ sensitive indicator cal520. MENPs were shown to wirelessly induce calcium transients which were synchronized with application of 1200-Oe bipolar 25-msec magnetic pulses at a rate of 20 pulses/sec. Full-Text PDF Open Access
Gene Expression Analysis of Urine Sediment: Evaluation for Potential Noninvasive Markers of Interstitial Cystitis/Bladder Pain Syndrome (2011)

Gene expression analysis of urine sediment was feasible in this pilot study. Expression profiles failed to discriminate nonHunner-lesion interstitial cystitis/bladder pain syndrome from controls and they are unlikely to be a noninvasive marker for nonHunner-lesion interstitial cystitis/bladder pain syndrome. In contrast, patients with Hunner lesion had increased proinflammatory gene expression in urine sediment, similar to that in a prior microarray study of bladder biopsies. If these preliminary results are validated in future research, they may lead to a noninvasive biomarker for Hunner lesion-interstitial cystitis/bladder pain syndrome.
Depth-based block partitioning for 3D video coding (2013)

3D video is an emerging technology that bundles depth information with texture videos to allow for view synthesis applications at the receiver. Depth discontinuities define object boundaries in both, depth maps and the collocated texture video. Therefore, segmentation of the depth map can be used for more accurate partitioning of the corresponding texture component. In this paper, already coded depth maps are used to increase coding efficiency for texture videos by deriving an arbitrarily shaped partitioning of a texture block based on the collocated depth block. By applying motion compensation to each partition and combining them afterwards by a depth-based segmentation mask, highly accurate prediction signals can be formed that reduce the remaining residual signal significantly. Simulation results show bitrate savings of up to 5.7% for the dependent texture views and up to 2.3% with respect to the total bitrate.
Comparison of Cellular Architecture, Axonal Growth, and Blood Vessel Formation Through Cell-Loaded Polymer Scaffolds in the Transected Rat Spinal Cord (2014)

The use of multichannel polymer scaffolds in a complete spinal cord transection injury serves as a deconstructed model that allows for control of individual variables and direct observation of their effects on regeneration. In this study, scaffolds fabricated from positively charged oligo[poly(ethylene glycol)fumarate] (OPF(+)) hydrogel were implanted into rat spinal cords following T9 complete transection. OPF(+) scaffold channels were loaded with either syngeneic Schwann cells or mesenchymal stem cells derived from enhanced green fluorescent protein transgenic rats (eGFP-MSCs). Control scaffolds contained extracellular matrix only. The capacity of each scaffold type to influence the architecture of regenerated tissue after 4 weeks was examined by detailed immunohistochemistry and stereology. Astrocytosis was observed in a circumferential peripheral channel compartment. A structurally separate channel core contained scattered astrocytes, eGFP-MSCs, blood vessels, and regenerating axons. Cells double-staining with glial fibrillary acid protein (GFAP) and S-100 antibodies populated each scaffold type, demonstrating migration of an immature cell phenotype into the scaffold from the animal. eGFP-MSCs were distributed in close association with blood vessels. Axon regeneration was augmented by Schwann cell implantation, while eGFP-MSCs did not support axon growth. Methods of unbiased stereology provided physiologic estimates of blood vessel volume, length and surface area, mean vessel diameter, and cross-sectional area in each scaffold type. Schwann cell scaffolds had high numbers of small, densely packed vessels within the channels. eGFP-MSC scaffolds contained fewer, larger vessels. There was a positive linear correlation between axon counts and vessel length density, surface density, and volume fraction. Increased axon number also correlated with decreasing vessel diameter, implicating the importance of blood flow rate. Radial diffusion distances in vessels significantly correlated to axon number as a hyperbolic function, showing a need to engineer high numbers of small vessels in parallel to improving axonal densities. In conclusion, Schwann cells and eGFP-MSCs influenced the regenerating microenvironment with lasting effect on axonal and blood vessel growth. OPF(+) scaffolds in a complete transection model allowed for a detailed comparative, histologic analysis of the cellular architecture in response to each cell type and provided insight into physiologic characteristics that may support axon regeneration.
Clinical effects of transcatheter hepatic arterial embolization with holmium-166 poly(l-lactic acid) microspheres in healthy pigs (2008)

It can be concluded that the toxicity profile of HoMS is low. In pigs, hepatic arterial embolization with (166)HoMS in amounts corresponding with liver-absorbed doses of over 100 Gy, if correctly administered, is not associated with clinically relevant side effects. This result offers a good perspective for upcoming patient trials.
Laser-driven short-duration heating angioplasty: Dilatation performance in cadaver atherosclerotic femoral arteries (2013)

The purpose of this study was to investigate the artery dilatation performance of the short-duration heating balloon catheter in cadaver stenotic arteries. We designed a prototype short-duration heating balloon catheter that can heat artery media to around 60 °C in 15−25 s by a combination of laser-driven heat generation and continuous fluid irrigation in the balloon. We performed ex vivo short-duration heating dilatation in the cadaver atherosclerotic femoral arteries (initial percent diameter stenosis was 36-98%), with the maximum balloon temperature of 65±5 °C, laser irradiation duration of 25 s, and balloon dilatation pressure of 3.5 atm. The artery lumen configurations before and after the dilatations were assessed with a commercial IVUS system. After the short-duration heating dilatations, the percent diameter stenosis was reduced below 30% without any artery tears or dissections. We estimated that the artery media temperature was raised to around 60 °C in which plaque thickness was below 0.8 mm by a thermal conduction calculation. The estimated maximum temperature in artery adventitia and surrounding tissue was up to 45 °C. We found that the short-duration heating balloon could sufficiently dilate the cadaver stenotic arteries, without thermal injury in artery adventitia and surroundings.
A shaping technique of substrate lens antennas with genetic algorithm (2005)

A powerful optimization procedure of substrate lens antennas has been proposed at millimeter wave frequencies. Compared to previous works, this approach is global and thus does not require the a priori knowledge of an initial lens profile computed with conventional GO-based synthesis techniques. Our design methodology combines a genetic algorithm with an efficient asymptotic analysis of the radiation characteristics of 3D substrate lens antennas.
110: Clinical Significance of Anti-Microbial Therapy in Chronic Prostatitis Associated with Nontraditional Uropathogens (2005)

You have accessJournal of UrologyModerated Poster, Saturday, May 21, 2005, 3:30 - 5:30 pm1 Apr 2005110: Clinical Significance of Anti-Microbial Therapy in Chronic Prostatitis Associated with Nontraditional Uropathogens J. Curtis Nickel, Neringa Zadeikis, Michael Spivey, and Shu-Chen Wu J. Curtis NickelJ. Curtis Nickel , Neringa ZadeikisNeringa Zadeikis , Michael SpiveyMichael Spivey , and Shu-Chen WuShu-Chen Wu View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34375-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "110: Clinical Significance of Anti-Microbial Therapy in Chronic Prostatitis Associated with Nontraditional Uropathogens." The Journal of Urology, 173(4S), p. 30 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 30 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information J. Curtis Nickel More articles by this author Neringa Zadeikis More articles by this author Michael Spivey More articles by this author Shu-Chen Wu More articles by this author Expand All Advertisement PDF downloadLoading ...
Ancient Impact and Aqueous Processes at Endeavour Crater, Mars (2012)

The rover Opportunity has investigated the rim of Endeavour Crater, a large ancient impact crater on Mars. Basaltic breccias produced by the impact form the rim deposits, with stratigraphy similar to that observed at similar-sized craters on Earth. Highly localized zinc enrichments in some breccia materials suggest hydrothermal alteration of rim deposits. Gypsum-rich veins cut sedimentary rocks adjacent to the crater rim. The gypsum was precipitated from low-temperature aqueous fluids flowing upward from the ancient materials of the rim, leading temporarily to potentially habitable conditions and providing some of the waters involved in formation of the ubiquitous sulfate-rich sandstones of the Meridiani region.
ACTAS (1985)

This paper describes a timing analysis system (ACTAS: ACcurate Timing Analysis System). This system analyzes the logical behaviors of VLSI. It verifies timings at flip-flops and detects timing errors. Then, it calculates path delays of the partial combinational circuits generating the errors. If they do not satisfy timing constraints, the system detects error paths. In this system, the former method based on behavior analysis is called DYNAMIC TIMING ANALYSIS and the latter method based on path analysis is called STATIC TIMING ANALYSIS. By use of this system, it improves the timing analysis efficiency of the complicated timing of VLSI.
Genotypic characterization and safety assessment of lactic acid bacteria from indigenous African fermented food products (2012)

The resistance to kanamycin and vancomycin is probably an intrinsic feature since similar observations were reported in the literature for LAB. Low prevalence of pathogenicity indicator traits were observed among the isolates especially with the presence of poor haemolytic activities and they could therefore be considered as interesting candidates for selection of starter cultures or probiotics for different applications.
Dill Extract Induces Elastic Fiber Neosynthesis and Functional Improvement in the Ascending Aorta of Aged Mice with Reversal of Age-Dependent Cardiac Hypertrophy and Involvement of Lysyl Oxidase-Like-1 (2020)

Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the vascular smooth muscle cells through the cross-linking of its soluble precursor, tropoelastin. Elastic fibers endow the large elastic arteries with resilience and elasticity. Normal vascular aging is associated with arterial remodeling and stiffening, especially due to the end of production and degradation of elastic fibers, leading to altered cardiovascular function. Several pharmacological treatments stimulate the production of elastin and elastic fibers. In particular, dill extract (DE) has been demonstrated to stimulate elastin production in vitro in dermal equivalent models and in skin fibroblasts to increase lysyl oxidase-like-1 (LOXL-1) gene expression, an enzyme contributing to tropoelastin crosslinking and elastin formation. Here, we have investigated the effects of a chronic treatment (three months) of aged male mice with DE (5% or 10% <i>v/v</i>, in drinking water) on the structure and function of the ascending aorta. DE treatment, especially at 10%, of aged mice protected pre-existing elastic lamellae, reactivated tropoelastin and LOXL-1 expressions, induced elastic fiber neo-synthesis, and decreased the stiffness of the aging aortic wall, probably explaining the reversal of the age-related cardiac hypertrophy also observed following the treatment. DE could thus be considered as an anti-aging product for the cardiovascular system.
Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer (2017)

Oral cancer is a prevalent cancer type on a global scale, whose traditional treatment strategies have several drawbacks that could in the near future be overcome through the development of novel therapeutic and prognostic strategies. Nanotechnology provides an alternative to traditional therapy that leads to enhanced efficiency and less toxicity. Various nanosystems have been developed for the treatment of oral cancer, including polymeric, metallic, and lipid-based formulations that incorporate chemotherapeutics, natural compounds, siRNA, or other molecules. This review summarizes the main benefits of using these nanosystems, in parallel with a particular focus on the issues encountered in medical practice. These novel strategies have provided encouraging results in both in vitro and in vivo studies, but few have entered clinical trials. The use of nanosystems in oral cancer has the potential of becoming a valid therapeutic option for patients suffering from this malignancy, considering that clinical trials have already been completed and others are currently being developed.