gebhart/patrepeval huggingface dataset:
Cats cloned from fetal and adult somatic cells by nuclear transfer (2005)

This work was undertaken in order to study the developmental competence of nuclear transfer (NT) into cat embryos using fetal fibroblast and adult skin fibroblast cells as donor nuclei. Oocytes were recovered by mincing the ovaries in Hepes-buffered TCM199 and selecting the cumulus oocyte complexes (COCs) with compact cumulus cell mass and dark color. Homogenous ooplasm was cultured for maturation in TCM199+10% fetal bovine serum (FBS) for 12 h and used as a source of recipient cytoplast for exogenous somatic nuclei. In experiment 1, we evaluated the effect of donor cell type on the reconstruction and development of cloned embryos. Fusion, first cleavage and blastocyst developmental rate were not different between fetal fibroblasts and adult skin cells (71.2 vs 66.8; 71.0 vs 57.6; 4.0 vs 6.1% respectively; P < 0.05). In experiment 2, cloned embryos were surgically transferred into the oviducts of recipient queens. One of the seven recipient queens was delivered naturally of 2 healthy cloned cats and 1 stillborn from fetal fibroblast cells of male origin 65 days after embryo transfer. One of three recipient queens was delivered naturally of 1 healthy cloned cat from adult skin cells of female origin 65 days after embryo transfer. The cloned cats showed genotypes identical to the donor cell lines, indicating that adult somatic cells can be used for feline cloning.
Electroforming free high resistance resistive switching of graphene oxide modified polar-PVDF (2015)

A new model is proposed for high resistance resistive switching in polar beta-polyvinylidene fluoride and graphene oxide composites. The device achieved high resistance resistive switching in the range of 10–100 μA current without electroforming.
Synthesis and Properties of Stereoregular Polyamides Derived from L-Tartaric Acid: Poly[(2S,3S)-2,3-Dimethoxybutylene alkanamide]s (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Properties of Stereoregular Polyamides Derived from L-Tartaric Acid: Poly[(2S,3S)-2,3-Dimethoxybutylene alkanamide]sJ. J. Bou, I. Iribarren, and S. Munoz-GuerraCite this: Macromolecules 1994, 27, 19, 5263–5270Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/ma00097a004https://doi.org/10.1021/ma00097a004research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Establishment of prostatic hyperplasia model with castration beagle canines]. (2003)

It is practicable to establish prostatic hyperplasia model in Beagle canines after two months of TP administration.
Regulation of cGMP by glucose‐6‐phosphate dehydrogenase through PDE5 In coronary artery (849.2) (2014)

Our laboratory has demonstrated that glucose‐6‐phosphate dehydrogenase (Glc‐6‐PD), the rate‐limiting enzyme in the pentose phosphate pathway, is a novel regulator of vascular smooth muscle contraction and phenotype. Inhibition of Glc‐6‐PD increases the contractile phenotype of coronary and pulmonary arteries by partly activating protein kinase G (PKG) pathway. PKG is activated by cyclic GMP (cGMP), which is increased in response to atrial natriuretic peptide (ANP) or nitric oxide and by inhibition of phosphodiesterase 5 (PDE5). Recently, using a combination of co‐immunoprecipitation and mass‐spec approach, we discovered that Glc‐6‐PD and PDE5 forms a complex in the coronary artery. Therefore, we hypothesized that inhibition of Glc‐6‐PD increases cGMP levels (which activates PKG) by decreasing the activity of PDE5 in coronary artery. To test our hypothesis, we incubated bovine left anterior descending artery (LAD) with Glc‐6‐PD inhibitors, 6‐aminonicotinamide (6‐AN, 1 µM) and dehydroepiandrosterone (DHEA, 100 µM); PDE5 inhibitor, sildenafil (Sil, 10 µM); Sil+6‐AN; and Sil+DHEA, in‐vitro for 12 hr and measured cGMP levels. Surprisingly and contrary to our expectations, we found that 6‐AN and DHEA decreased basal cGMP levels by 52 and 65%, respectively, as compared to control. While Sil increased cGMP by 324%, 6‐AN and DHEA reduced Sil‐induced increase in cGMP (Sil+6‐AN; 184% and Sil+DHEA; 133%). In conclusion, our novel findings demonstrate that: 1] inhibition of Glc‐6‐PD increases PKG activity via a cGMP‐independent pathway, 2] Glc‐6‐PD interacts with PDE5, and 3] Glc‐6‐PD‐derived redox signaling is an inhibitor of PDE5. These findings suggest that in diabetes or metabolic syndrome increased redox signaling may counter‐intuitively decrease the efficacy of PDE5 blockers. Grant Funding Source : NIHHL085352
The Tumor Necrosis Factor-like Weak Inducer of Apoptosis (TWEAK)-Fibroblast Growth Factor-inducible 14 (Fn14) Signaling System Regulates Glioma Cell Survival via NFκB Pathway Activation and BCL-XL/BCL-W Expression (2004)

The Fn14 gene encodes a type Ia transmembrane protein that belongs to the tumor necrosis factor receptor superfamily. We recently showed that fibroblast growth factor-inducible 14 (Fn14) is overexpressed in migrating glioma cells in vitro and in glioblastoma multiforme clinical specimens in vivo. To determine the biological role of Fn14 in brain cancer progression, we examined the activity of Fn14 as a potential mediator of cell survival. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-stimulated glioma cells had increased cellular resistance to cytotoxic therapy-induced apoptosis. Either TWEAK treatment or Fn14 overexpression in glioma cells resulted in the activation of NFkappaB and subsequently the translocation of NFkappaB from the cytoplasm to the nucleus. In addition, Fn14 activation induced BCL-XL and BCL-W mRNA and protein levels, and this effect was dependent upon NFkappaB transcriptional activity. Substitution of a putative NFkappaB binding site identified in the BCL-X promoter significantly decreased Fn14-induced transactivation. Furthermore Fn14-induced transactivation of the BCL-X promoter was also diminished by the super-repressor IkappaBalpha mutant, which specifically inhibits NFkappaB activity, and by mutations in the NFkappaB binding motif of the BCL-X promoter. Additionally small interfering RNA-mediated depletion of either BCL-XL or BCL-W antagonized the TWEAK protective effect on glioma cells. Our results suggest that NFkappaB-mediated up-regulation of BCL-XL and BCL-W expression in glioma cells increases cellular resistance to cytotoxic therapy-induced apoptosis. We propose that the Fn14 protein functions, in part, through the NFkappaB signaling pathway to up-regulate BCL-XL and BCL-W expression to foster malignant glioblastoma cell survival. Targeted therapy against Fn14 as an adjuvant to surgery may improve management of invasive glioma cells and advance the outcome of this devastating cancer.
Selective oxidation of glycerol to dihydroxyacetone using CeO2-ZrO2-Bi2O3-SnO2-supported platinum catalysts (2020)

The effects of the Bi3+ introduction and the oxygen release and storage abilities on selective oxidation of glycerol into dihydroxyacetone (DHA) were demonstrated using Pt/CeO2-ZrO2-Bi2O3-SnO2/SBA-16 (SBA-16: Santa Barbara Amorphous No. 16) catalysts. By introducing Bi3+ or Sn4+/2+ ions into the CeO2-ZrO2 promoter, the oxygen release and storage abilities were enhanced, which led to increased glycerol conversion. The improvement in the DHA yield was affected by the introduction of Bi3+, which might accelerate selective oxidation of a secondary hydroxy group in glycerol caused by the geometric effect. The highest activity was obtained for Pt/Ce0.64Zr0.16Bi0.15Sn0.05O2−δ/SBA-16, which showed high oxygen release and storage abilities and a high number of Bi3+ ions, with the DHA yield increasing to 53% and high rates of glycerol conversion (74%) and DHA selectivity (72%) after reaction at a moderate temperature of 30 °C for 4 h in atmospheric air.
Optimizing for reduced code space using genetic algorithms (1999)

Code space is a critical issue facing designers of software for embedded systems. Many traditional compiler optimizations are designed to reduce the execution time of compiled code, but not necessarily the size of the compiled code. Further, different results can be achieved by running some optimizations more than once and changing the order in which optimizations are applied. Register allocation only complicates matters, as the interactions between different optimizations can cause more spill code to be generated. The compiler for embedded systems, then, must take care to use the best sequence of optimizations to minimize code space.Since much of the code for embedded systems is compiled once and then burned into ROM, the software designer will often tolerate much longer compile times in the hope of reducing the size of the compiled code. We take advantage of this by using a genetic algorithm to find optimization sequences that generate small object codes. The solutions generated by this algorithm are compared to solutions found using a fixed optimization sequence and solutions found by testing random optimization sequences. Based on the results found by the genetic algorithm, a new fixed sequence is developed to reduce code size. Finally, we explore the idea of using different optimization sequences for different modules and functions of the same program.
Diskrete Sensoren - wie lässt sich intelligente Steuerung mit dem Schutz der Privatsphäre vereinen? - Campusreport am 21.01.2014 (2014)

Sensoren sind aus unserem Leben nicht mehr weg zudenken: Sensoren im Smartphone helfen uns bei der Navigation. Sensoren im Haus helfen uns sparen, wenn sie unsere Waschmaschine zum richtigen Zeitpunkt starten oder das Licht ausmachen und die Heizung herunterfahren, wenn wir das Haus verlassen. Was unser Leben so bequem macht, hat aber auch einen großen Nachteil: Sensoren produzieren Daten, die abgefangen werden können und mehr über unser Privatleben preisgeben, als uns lieb ist.
Androgen-Receptor Gene CAG Repeats, Plasma Testosterone Levels, and Risk of Hepatitis B-Related Hepatocellular Carcinoma (2000)

Higher levels of androgen signaling, reflected by higher testosterone levels and 20 or fewer AR-CAG repeats, may be associated with an increased risk of HBV-related HCC in men.
Nm23-H1 Regulates Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells via Arf6-Rac1 Signaling Axis (2013)

We conclude that the nm23-H1 activation step is upstream of Arf6 activation in signaling events leading to GSIS. NDP kinase and histidine kinase functions of nm23-H1 are necessary for glucose-induced membrane association of Rac1 and ensuing insulin secretion. We present the first evidence for regulation of GSIS by nm23-H1 in pancreatic β-cells.
ISDN3: the next generation networks (2002)

Two generations of integrated services digital network (ISDN), namely ISDN1 and ISDN2, have been developed in the last century. In our view, the convergence of ATM, Internet and active networks will form the basis for the next generation networks called ISDN3. We first review ISDN1 and ISDN2 as well as the Internet and active networks. We then discuss some fundamental questions related to the design of ISDN3. Finally, we compare ISDN3 with ISDN1 and ISDN2, and outline what ISDN3 might look like.
Historical Comments on Stress Relaxation Following Steady Flows Through a Duct or Orifice (1969)

The early scientific literature relating to the geometry of a jet of fluid as it emerges from a duct or orifice is considered. This stress-relaxation problem has become variously known as the “Barus effect” or “Merrington phenomenon”. Both of these designations are seen to be incorrect historically and their discontinuance is recommended in favor of a phrase description of the material behavior, such as “extrudate expansion.”
Plankton development in a rapidly flushed lake in the River Spree system (Neuendorfer See, Northeast Germany) (1998)

The Neuendorfer See is a shallow lake through which the River Spree flows. In the lake, abundances of zooplankton (mainly rotifers) and phytoplankton increased exponentially over the flowing stretch between the inflow and the outflow of the river. Increase in space is enhanced by increased residence time in the lake. Sensitivity of plankton development on residence times of <8 days weakened at longer residence times. This pattern holds for all zooplankton species. Rates of change in chlorophyll and rotifers (after correction for temperature) are first enhanced, then are decreased at longer residence times. Concentrations of dissolved inorganic nutrients [Si, soluble reactive phosphorus (SRP) and NO 3 "] and the N/P ratio diminished with increasing residence time. The plankton dynamics in the lake were dependent on discharge and the lake behaved as a 'plug flow tubular reactor' with minor longitudinal mixing. This was not different from the transportation in large rivers.
Modeling actions and operations to support mission preparation (1994)

This paper describes two linked technology development projects to support Space Shuttle ground operations personnel, both during mission preparation analysis and related analyses in missions. The Space Propulsion Robust Analysis Tool (SPRAT) will provide intelligent support and automation for mission analysis setup, interpretation, reporting and documentation. SPRAT models the actions taken by flight support personnel during mission preparation and uses this model to generate an action plan. CONFIG will provide intelligent automation for procedure analyses and failure impact analyses, by simulating the interactions between operations and systems with embedded failures. CONFIG models the actions taken by crew during space vehicle malfunctions and simulates how the planned action sequences in procedures affect a device model. Jointly the SPRAT and CONFIG projects provide an opportunity to investigate how the nature of a task affects the representation of actions, and to determine a more general action representation supporting a broad range of tasks. This paper describes the problems in representing actions for mission preparation and their relation to planning and scheduling.
[Results obtained from lumbar catheterisation for epidural analgesia for painless labour (author's transl)]. (1980)

Experience obtained from 115 childbirths with catheterisation for epidural analgesia is reported in this paper. Reduction of labour pain was optimum with all patients.--The rate of CTG alterations and acidosis of foetal blood was not beyond that recordable from normal deliveries. The rate of vaginal surgery was increased to 14.8 per cent due to one patient in whom expulsion was delayed and the expulsion period thus prolonged.
Polymers as Reagents in Organic Synthesis (1974)

Abstract Polymeric reagents offer a range of unique advantages. Intramolecular reactions, such as the cyclization of peptides or Dieckmann cyclizations, can be brought about by attaching the reactive molecules at remote points along a polymer chain. In contrast, if the reactive molecules are anchored in close proximity on a polymeric support then intermolecular reactions occur, as demonstrated for a ketone synthesis. Apart from such proximity effects, cooperative effects can also be exploited, e.g. in the formation of a 2:1 complex of a crown ether and an alkali metal ion. The hydrolysis of an ester with polyvinylimidazole provides a detailed illustration of hydrophobic interactions. The simple separation of polymer‐bound and low‐molecular compounds by filtration is another significant advantage.
Triterpenoids from Mangifera indica (1989)

A new pentacyclic triterpenoid, hopane-1ß,3ß,22-triol, was isolated from the neutral fraction of the n-hexane extract of the stem bark of Mangifera indica. From the acidic fraction of the same extract four new tetracyclic triterpenoids, 3a,22(R or S)-dihydroxycycloart-24E-en-26-oic acid, 3ß,22(R or S)-dihydroxycycloart-24E-en-26-oic acid, 3ß,23(R or S)-dihydroxycycloart-24E-en-26-oic acid and 3a,27-dihydroxycycloart-24E-en-26-oic acid were isolated. The structures were elucidated by spectroscopic and chemical methods.
Sum Frequency Generation Vibrational Spectroscopic Studies on a Silane Adhesion-Promoting Mixture at a Polymer Interface (2005)

Sum frequency generation (SFG) vibrational spectroscopy was used to probe the interface between poly(ethylene terephthalate) with deuterated ethylene glycol subunits (d4-PET) and a silane adhesion-promoting mixture (SAPM) comprised of (3-glycidoxypropyl)trimethoxysilane (gamma-GPS) and a methylvinylsiloxanol (MVS). Such a mixture has been found to improve the adhesion of an addition-curing silicone elastomer to a range of plastic and metal substrates. Our results demonstrated that at the interface between d4-PET and a SAPM with a gamma-GPS/MVS ratio of 1:1 (w/w), the silane molecules not only segregated to the interface but also the methoxy headgroups likely adopted a greater net orientational order along the surface normal than at the d4-PET/gamma-GPS interface. The effects of varying the silane/siloxane ratio and using different siloxane oligomers on interfacial structures were also examined. This study provides unique molecular-level insights into the prerequisite conditions for adhesion of curable silicone adhesives.
Influence of Temperature and Relative Humidity on Sporulation of Cercospora zeae-maydis and Expansion of Gray Leaf Spot Lesions on Maize Leaves (2005)

Controlled environment studies were conducted to determine the effects of temperature on the expansion of lesions of gray leaf spot, and the effects of temperature and relative humidity on the sporulation of Cercospora zeae-maydis on maize (Zea mays). For the lesion expansion experiment, potted maize plants were spray inoculated at growth stage V6, bagged, and incubated at 25 to 28°C and 100% relative humidity for 36 to 40 h. Symptomatic plants were transferred to growth chambers and exposed to constant temperatures of 25, 30, and 35°C. Lesion area (length by width) was measured at 4-day intervals for 17 days. For sporulation studies, lesions were excised from naturally infected maize leaves, measured, and incubated at constant temperature (20, 25, 30, or 35°C) and relative humidity (70, 80, 90, or 100%) for 72 h. Sporulation was estimated as the number of conidia per square centimeter of diseased leaf tissue. A quadratic function was used to model the relationship between log-transformed conidia per square centimeter at 100% relative humidity and temperature. Temperature had a significant effect on lesion expansion (P ≤ 0.05). At 25 and 30°C, the rate of lesion expansion was significantly higher than at 35°C (P ≤ 0.05). The largest lesions and the highest mean rate of lesion expansion were observed at 30°C; however, the mean lesion expansion rate at this temperature was not significantly different from that at 25°C. The interaction effect of temperature and relative humidity on the log of conidia per square centimeter of diseased tissue was significant (P ≤ 0.05). At 100% relative humidity, the effect of temperature on sporulation was significant (P ≤ 0.05), with maximum spore production occurring at 25 and 30°C. The quadratic model explained between 49 and 80% of the variation in the log of conidia per square centimeter at 100% with variation in temperature. These results suggest that the rapid increase in gray leaf spot severity generally observed during mid- and late summer may be due to favorable conditions for lesion expansion during this period. When relative humidity is &gt;95%, expanding lesions may serve as a source of inoculum for secondary infections.
Route Optimization and Synthesis of Taxadienone (2014)

Early process development toward the scalable production of taxadienone on a decagram scale is described. A continuous flow reactor was employed to safely run a potentially hazardous cyclopropane ring opening. The route featured two copper-mediated additions, a Diels–Alder reaction and a palladium-catalyzed Negishi coupling, to construct the final structure.
Solvation and Dynamic Behavior of Cyclodextrins in Dimethyl Sulfoxide Solution (2006)

High-frequency dielectric relaxation behavior up to 20 GHz was investigated for plain (alpha, beta, gamma) and (62 and 100%) methylated cyclodextrins, CDs, in dimethyl sulfoxide, DMSO, solution. Each hydrogen atom of OH groups of the CDs solvated a DMSO molecule for a residence time of 130-180 ps due to the hydrogen bond formation to an oxygen atom of DMSO, and a few DMSO molecules were included in cavities of the CDs for a while similar to the residence time. The overall rotational relaxation modes of solvated CDs were also observed depending on the effective sizes of the solvated CDs.