gebhart/patrepeval huggingface dataset:
Total Eclipse - an Efficient Architectural Realization of the Parallel Random Access Machine (2010)

We have introduced the TOTAL ECLIPSE CMP architecture providing an efficient realization of PRAM. In addition to providing synchronous access to the shared memory, it allows for concurrent references to memory location, special multioperations performing computations between the participating threads, modes for efficient parallel execution and fast sequential operation combining the computational power of threads and seamless configurability between these modes. According to our evaluation TOTAL ECLIPSE provides in many cases performance close to similarly configured ideal PRAM, while the silicon area and power consumption are somewhat comparable to the current commercial CMPs. This chapter acts also as a case-driven introduction to novel parallel architecture techniques, including synchronization wave, cacheless memory organization, chaining, step caching, bunching, and scratchpads, that are unknown from the theory of sequential architectures. Our future research interests related to this topic include building FPGA and silicon prototypes of TOTAL ECLIPSE, addressing the off-chip memory efficiency problem, as well as investigating the limits of practical scalability of this kind of architectures.
Painting with light: Gesture based light control in architectural settings (2017)

Lighting can play an essential role in supporting user tasks as well as creating an ambiance. Although users may feel excited about the supported functionality when a complex indoor lighting system is first deployed, the lack of a convenient interface may prevent them from taking the full advantage of the system. We propose a system and a 3D interaction technique for controlling indoor lights. The system is extendable and supports multiple users to control lights using either gestures or a GUI. Using a single Kinect sensor, the user is able to control lights from different positions in the room while standing or sitting down within the tracking range of the sensor. The selection and manipulation accuracy of the proposed technique together with the ease of use compared to other alternatives makes it a promising lighting control technique.
Expression analysis of jagged genes in zebrafish embryos (2005)

The interaction of transmembrane Delta and Jagged/Serrate ligands with Notch receptors on neighboring cells is critically involved in cell specification during development. In zebrafish, the early expression of delta but not of jagged genes has been investigated in some detail. We have analyzed the sequence and embryonic expression pattern of the three zebrafish genes jagged1a, jagged1b, and jagged2. These genes, whose transcripts are detectable by in situ hybridization from early somitogenesis, are widely and dynamically expressed in embryos. Coexpression is limited, however, to the notochord and lens (jagged1a and jagged1b) and to the otic vesicle and pronephros (jagged1b and jagged2). Conversely, jagged1a and jagged2, both widely expressed in the central nervous system, are not coexpressed. jagged2 is also detected in the epidermis, newly formed somites, pharyngeal pouches, and pancreatic exocrine anlage and jagged1b in otic placodes and cell clusters close to the pancreatic islet. The similarities of the expression patterns of jagged and delta genes in zebrafish suggest that the Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes.
Small Scale European Databases And GPS Application (2005)

This paper presents a technology for a European scale geographic database for international transportation applications: the Global Positioning System. Using a highly sophisticated procedure of nation-based projective transformations followed by a tailor-made non-projective transformation, the result is a geometrically uniform and seamless European database.
Imitation Learning for Variable Speed Object Manipulation. (2021)

To operate in a real-world environment, robots have several requirements including environmental adaptability. Moreover, the desired success rate for the completion of tasks must be achieved. In this regard, end-to-end learning for autonomous operation is currently being investigated. However, the issue of operating speed has not been investigated in detail. Therefore, in this paper, we propose a method for generating variable operating speeds while adapting to perturbations in the environment. When the work speed changes, there is a nonlinear relationship between the operating speed and force (e.g., inertial and frictional forces). However, the proposed method can be adapted to nonlinearities by utilizing small amount of motion data. We experimentally evaluated the proposed method for erasing a line using an eraser fixed to the tip of a robot. Furthermore, the proposed method enables a robot to perform a task faster than a human operator
Translational motion compensation for coronary angiogram sequences (1989)

A method of compensating for the lag of the video cameras typically used in angiographic systems is presented for use in sequences of digitized X-ray images. The lag effect is reduced by a straightforward weighted subtraction, which has the undesirable side effect of increasing noise. By superimposing several lag-corrected and appropriately shifted images, however, the signal-to-noise ratio can be restored. The algorithm uses the phase-correlation method to measure the two-dimensional shift of a mobile coronary arterial structure. Processing is confined to a rectangular area of interest (AOI), which encloses a feature of clinical significance. The differences of the phases of the Fourier transforms of two frames is computed, combined with an appropriate filter, and inverse Fourier-transformed to produce a phase-correlation image. The vector separation from the origin of image space of the peak of the phase-correlation image is the estimate of the shift of the artery's position in the second frame as compared to the first. The isolation of the AOI from the surrounding image is achieved by the application of a window and correction for any linear trend in the background intensity.
Restricting the Weak-Generative Capacity of Synchronous Tree-Adjoining Grammars (1994)

The formalism of synchronous tree-adjoining grammars, a variant of standard tree-adjoining grammars (TAG), was intended to allow the use of TAGs for language transduction in addition to language specification. In previous work, the definition of the transduction relation defined by a synchronous TAG was given by appeal to an iterative rewriting process. The rewriting definition of derivation is problematic in that it greatly extends the expressivity of the formalism and makes the design of parsing algorithms difficult if not impossible. We introduce a simple, natural definition of synchronous tree-adjoining derivation, based on isomorphisms between standard tree-adjoining derivations, that avoids the expressivity and implementability problems of the original rewriting definition. The decrease in expressivity, which would otherwise make the method unusable, is offset by the incorporation of an alternative definition of standard tree-adjoining derivation, previously proposed for completely separate reasons, thereby making it practical to entertain using the natural definition of synchronous derivation. Nonetheless, some remaining problematic cases call for yet more flexibility in the definition; the isomorphism requirement may have to be relaxed. It remains for future research to tune the exact requirements on the allowable mappings.
Ibuprofen and sulindac kinetics in alcoholic liver disease (1983)

Ibuprofen and sulindac kinetics after oral doses were compared in 15 patients with alcoholic liver disease and 29 normal subjects. The patients with alcoholic liver disease were divided into a group with fair hepatic function (FHF) and a group with poor hepatic function (PHF) based on elimination rates of indocyanine green. The effects of alcoholic liver disease on the ibuprofen kinetics were minimal. The absorption of the drug appeared to be delayed in some of the PHF patients, and slight differences were noted in the serum AUC and the elimination rate constant for ibuprofen. The absorption of sulindac was delayed in both PHF and FHF groups of patients, as was the appearance of the active metabolite, sulindac sulfide, and the inactive metabolite, sulindac sulfone. The plasma AUC for sulindac sulfide in patients with poor hepatic function was four times that in normal subjects. The kinetics of sulindac, a pro-drug that relies on the liver for conversion to an active metabolite, were markedly affected by alcoholic liver disease.
A new technique for noise figure measurements of millimetre-wave mixers (2000)

A novel noise measurement method for mixers which exploits mixer noise figure variation with LO power is reported. The method allows for the first time high noise figures, e.g. at the maximum conversion gain point of millimetre wave mixers, to be found. With the technique proposed, noise figures as high as 20 dB can be accurately measured. The suggested method and its advantage over the conventional hot/cold noise measurement are demonstrated for a 65 GHz millimetre-wave GaAs MMIC down converter. For the mixer under test, the measured noise figures obtained were 9.3 dB with 7 dBm LO power and 15.1 dB with 13 dBm LO power, and the respective conversion gains were –1 dB (low noise point) and +3 dB (maximum conversion gain point).
Multimarker analysis of T-cell chronic lymphocytic leukemia (1978)

A 68-yr-old male with chronic lymphocytic leukemia (CLL) presented with splenomegaly and skin infiltration but no lymphadenopathy. The peripheral blood WBC cound was 300 x 10(9)/liter, with 95% small mature- appearing lymphocytes that were E-rosette positive and EAC-rosette negative. Further characterization of the patient's cells was performed using antisera with known lymphoid sub-population specificity. Anti- p23,30, which reacts with normal circulating B cells but not with T cells or thymocytes, was unreactive with the patient's cells. Anti-311, which reacts with both thymocytes and circulating T cells, was reactive with the patient's cells. Anti-Bk, which reacts only with thymocytes and not with circulating T-cells, failed to react with the patient's cells. The enzyme terminal deoxynucleotidyl transferase, present in thymocytes but absent for circulating T-cells, was also absent from the patient's lymphoid cells. Multimarker analysis therefore showed a mature T-lymphocyte phenotype on this patient's leukemia cells. Further functional analysis will probably show that such cells represent clonal expansion of a mature T-cell subpopulation, analogous to the B-cell clonality of common-variant CLL.
The Drosophila transcript encoded by the β-amyloid protein precursor-like gene is restricted to the nervous system (1990)

We have molecularly delineated a Drosophila beta-amyloid protein precursor-like (Appl) gene and analyzed its pattern of expression. Appl defines a new locus within the 1B division of the X-chromosome, a region previously shown to be important for neural development. The genomic limits of the Appl gene were defined by mapping of the Appl cDNAs. The Appl transcript spans approximately 38 kb (1 kb = 10(3) base-pairs) of genomic DNA. Genomic regions surrounding the first two exons were sequenced. The first exon contains 78 nucleotides of the coding sequence and is separated from the second exon by a approximately 21 kb intron. The second exon is 171 nucleotides long and is separated from the third exon by a approximately 7 kb intron. We present in situ RNA localization data that demonstrate that the Appl transcript is found in post-mitotic neurons in all developmental stages, in the central and peripheral nervous systems. Within the nervous system transcripts are not observed in neuroblasts, newly generated neurons and at least one class of presumed glial cells. The temporal and spatial specificity of Appl expression suggests that the gene product has a function that is common to most neurons. Appl cDNA predicts an 886-amino acid polypeptide that exhibits strong sequence similarity to the human beta-amyloid protein precursor (APP) (Rosen et al. 1989). In this paper, we compare the Appl gene expression with the pattern of expression of the beta-amyloid protein precursor (APP) gene in mammals. Furthermore, we suggest that during evolution, a neural-specific function encoded by the APP gene has been selectively maintained.
EVIDENCE FOR THE PAIR FORMATION FAR ABOVE Tc IN EPITAXIAL La2-xSrxCuO4 THIN FILMS (2002)

A large positive magnetoresistivity (up to ten percent or more) is observed for both under-doped and over-doped superconducting La 2-x Sr x CuO 4 epitaxial thin films at temperatures far above the superconducting critical temperature T c . This magnetoresistivity can be related to the pairs eventually forming the superconducting phase at low temperatures. Our observations support the idea of a close relation between the pseudogap and the superconducting gap and provide new indications for the presence of pre-pairs above T c .
DARPA challenge: developing new technologies for brain and spinal injuries (2012)

The repair of traumatic injuries to the central nervous system remains among the most challenging and exciting frontiers in medicine. In both traumatic brain injury and spinal cord injuries, the ultimate goals are to minimize damage and foster recovery. Numerous DARPA initiatives are in progress to meet these goals. The PREventing Violent Explosive Neurologic Trauma program focuses on the characterization of non-penetrating brain injuries resulting from explosive blast, devising predictive models and test platforms, and creating strategies for mitigation and treatment. To this end, animal models of blast induced brain injury are being established, including swine and non-human primates. Assessment of brain injury in blast injured humans will provide invaluable information on brain injury associated motor and cognitive dysfunctions. The Blast Gauge effort provided a device to measure warfighter's blast exposures which will contribute to diagnosing the level of brain injury. The program Cavitation as a Damage Mechanism for Traumatic Brain Injury from Explosive Blast developed mathematical models that predict stresses, strains, and cavitation induced from blast exposures, and is devising mitigation technologies to eliminate injuries resulting from cavitation. The Revolutionizing Prosthetics program is developing an avant-garde prosthetic arm that responds to direct neural control and provides sensory feedback through electrical stimulation. The Reliable Neural-Interface Technology effort will devise technologies to optimally extract information from the nervous system to control next generation prosthetic devices with high fidelity. The emerging knowledge and technologies arising from these DARPA programs will significantly improve the treatment of brain and spinal cord injured patients.
Use of a stable‐isotope‐labeled reporter peptide and antioxidants for reliable quantification of methionine oxidation in a monoclonal antibody by liquid chromatography/mass spectrometry (2016)

The methodology which utilizes the reference stable-isotope-labeled reporter peptide is applicable to monoclonal antibody oxidation analysis and could be extended to other biotherapeutics once oxidation-prone methionine(s) in the protein sequence are identified. Copyright © 2016 John Wiley & Sons, Ltd.
Near Infrared Reflectance Spectroscopy for the Analysis of Agricultural Soils (1999)

The objective of this work was to investigate the usefulness of near infrared (NIR) reflectance spectroscopy in determining: (i) various constituents (total N, total C, active N, biomass and mineralisable N, and pH), (ii) parameters (soil source, depth from which sample was obtained, type of tillage used) and (iii) rate of application of NH 4 NO 3 fertiliser) of low organic matter soils. A NIRSystems model 6250 spectrometer was used to scan soil samples ( n = 179) obtained from experimental plots at two locations with three replicate plots under plow and no till practices at each location with three rates of NH 4 NO 3 for each plot (2 × 3 × 2 × 3). For each of these, samples were taken from five depths for a total of 2 × 3 × 2 × 3 × 5 or 180 samples (one sample lost). The results demonstrated that NIR reflectance spectroscopy can be successfully used to determine some compositional parameters of low organic matter soils (particularly total C and total N). It is also apparent that for non-biological parameters (excluding soil type as reflected by source) such as the depth from which the sample was obtained, the rate of application of NH 4 NO 3 fertiliser and the form of tillage used, that NIR reflectance spectroscopy is not very useful, unless a very limited set of samples is used (i.e. single tillage and location). For other determinations, such as pH, biomass N and active N, the results may be useful depending on the exact needs in question. Finally, from the results presented here, NIR reflectance spectroscopy was not successful in determining soil N mineralisable in 21 days.
Progastrin, a novel ubiquitous cancer blood biomarker for early detection and monitoring. (2019)

3037 Background: The successes of recent publications on “multi-tumor” circulating markers highlight the relevance of novel universal diagnostic cancer serum biomarkers. Since the Wnt/ß-catenin/Tcf4 pathway, activated in many tumors, induces the GAST Gene encoding progastrin synthesis, we hypothesized that progastrin, easily measurable in the blood, might be a “multi-tumor” diagnostic biomarker. Methods: Progastrin levels were measured in the blood samples of 1319 patients with 12 different cancer origins, and compared to those of 557 asymptomatic 18-75 years old blood donors. Moreover the longitudinal kinetics of progastrin concentrations were serially assessed during treatments in 168 patients with ovarian cancers enrolled in the randomized CHIVA trial (NCT01583322, GINECO), 191 patients with peritoneal involvement from gastro-intestinal cancers enrolled in BIG-RENAPE trial (NCT03787056), and in 95 HCC patients. The progastrin was measured using an ELISA test developed by ECS Progastrin (Prilly, Switzerland). Results: Compared to healthy blood donors, progastrin was found at higher concentrations in the plasma of cancer patients: median 4.47 vs 0.20 pM, P &lt; 0.0001; diagnostic discriminative power, ROC analysis AUC = 0.86 (95% CI, 0.83-0.89; P &lt; 0.0001). Progastrin levels were found elevated in all cancer groups, regardless of disease stages, and of pathology origins: ROC AUCs ranged from 0.71 to 0.93, all P &lt; 0.0001 (Table). The longitudinal progastrin changes during treatments, suggest relationships to tumor burden, and potential monitoring value. Conclusions: Progastrin is a novel ubiquitous cancer biomarker, easily detectable in the blood using an affordable ELISA test (CancerRead Lab test(R)). It may change the future paradigms about screening (in particular for populations at higher or lower risks of cancer), cancer diagnostic &amp; monitoring. [Table: see text]
New Alkaloids from Annona purpurea (2000)

Three new alkaloids, promucosine (1), romucosine F (2), and romucosine G (3), along with 28 known compounds, were isolated from the MeOH extract of stems of Annona purpurea. The structures of 1-3 were determined on the basis of spectral data and chemical evidence.
124 Design optimization of hydro turbine by using MOGA and DOE (2010)

An optimization system coupling CFD and design tool of Francis turbine runner shape with Multi-Objective Genetic Algorithm (MOGA) and Design of Experiences (DOE) is presented. The system is consists two processes. One is based on MOGA, and the other is based on DOE. At the first process, runner design parameters are automatically optimized according to objective function. At the second process, optimized runner which optimized first process is selected as base runner, and the runner design parameters are optimized by DOE. The system was applied to low specific speed Francis turbine runner. Hydraulic loss of runner and draft tube were selected for objective function. As the result of the optimization, high performance runner which has high turbine efficiency and low pressure fluctuation was obtained.
Regulation der adulten Neurogenese durch Pramipexol (2007)

Einleitung: Für die motorischen Defizite des idiopathischen Parkinsonsyndroms (IPS) steht der fortschreitende Verlust dopaminerger Neurone im Bereich der Substantia Nigra (SN) im Vordergrund. Zusätzlich zu diesen degenerativen Veränderungen wurde in früheren Studien eine verminderte Proliferation von neuronalen Vorläuferzellen in den Regionen der adulten Neurogenese, der Subventriculären Zone (SVZ) und dem Hippocampus beobachtet. Dopaminagonisten (DA) werden in der Therapie des IPS in frühen Stadien eingesetzt und nuklearmedizinische Daten deuten auf eine mögliche neuroprotektive Wirkung von Non-Ergot Dopaminagonisten hin. Um die Wirkung des Non-Ergot DA Pramipexol (PPX) in Regionen adulter Neurogenese zu testen, untersuchten wir den Einfluss von PPX auf die Proliferation, Differenzierung und Überleben von adulten neuralen Vorläuferzellen in 6-Hydroxydopamin (6-OHDA) läsionierten Ratten.
Theory of a thin biconical antenna located near the air-ground interface (1975)

Previous analyses of the input impedance of a thin biconical antenna are extended to include the effect of the air-ground interface. It is supposed that the antenna could be vertically located in the air or embedded in a spherical insulating cavity. The description of the basic theory is given and the electrical characteristics of the antenna such as the input impedance and the current distribution are determined, Illustrative calculations show that the air-ground interface changes the value of the input impedance but, as in the case of cylindrical antennas, the current dissymmetry only occurs if the antenna is situated very near the interface. Therefore, the shapes of the radiation patterns are nearly the same as those obtained by assuming a sinusoidal current repartition.
Enzymatic mechanism of human apurinic/apyrimidinic endonuclease against a THF AP site model substrate (2009)

The endonucleolytic activity of human apurinic/apyrimidinic endonuclease (AP endo) is a major factor in the maintenance of the integrity of the human genome. There are estimates that this enzyme is responsible for eliminating as many as 10 5 potentially mutagenic and genotoxic lesions from the genome of each cell every day. Furthermore, inhibition of AP endonuclease may be effective in decreasing the dose requirements of chemotherapeutics used in the treatment of cancer as well as other diseases. Therefore, it is essential to accurately and directly characterize the enzymatic mechanism of AP endo. Here we describe specifically designed double stranded DNA oligomers containing tetrahydrofuran (THF) with a 5' phosphorothioate linkage as the abasic site substrate. Using H 2 18 O during the cleavage reaction and leveraging the stereochemical preferences of AP endo and T4 DNA ligase for phosphorothioate substrates, we show that AP endo acts by a one‐step associative phosphoryl transfer mechanism on a THF‐containing substrate. Supported by National Institutes of Health Grant CA 72702 (to P.R.S.), and NIH Grant CA80024 and NIEHS Grant P30 ES002109 (to J.M.E.)