gebhart/patrepeval huggingface dataset:
Concise Review: Canine Diabetes Mellitus as a Translational Model for Innovative Regenerative Medicine Approaches (2019)

Diabetes mellitus (DM) is a common spontaneous endocrine disorder in dogs, which is defined by persistent hyperglycemia and insulin deficiency. Like type 1 diabetes (T1D) in people, canine DM is a complex and multifactorial disease in which genomic and epigenomic factors interact with environmental cues to induce pancreatic β-cell loss and insulin deficiency, although the pathogenesis of canine DM is poorly defined and the role of autoimmunity is further controversial. Both diseases are incurable and require life-long exogenous insulin therapy to maintain glucose homeostasis. Human pancreatic islet physiology, size, and cellular composition is further mirrored by canine islets. Although pancreatic or isolated islets transplantation are the only clinically validated methods to achieve long-term normoglycemia and insulin independence, their availability does not meet the clinical need; they target a small portion of patients and have significant potential adverse effects. Therefore, providing a new source for β-cell replacement is an unmet need. Naturally occurring DM in pet dogs, as a translational platform, is an untapped resource for various regenerative medicine applications that may offer some unique advantages given dogs' large size, longevity, heterogenic genetic background, similarity to human physiology and pathology, and long-term clinical management. In this review, we outline different strategies for curative approaches, animal models used, and consider the value of canine DM as a translational animal/disease model for T1D in people. Stem Cells Translational Medicine 2019;8:450-455.
Data from Polymorphisms in the Nonhomologous End-joining DNA Repair Pathway are Associated with HPV Integration in Cervical Dysplasia (2023)

&lt;div&gt;Abstract&lt;p&gt;Previous evidence indicates that human papillomavirus (HPV) integration status may be associated with cervical cancer development and progression. However, host genetic variation within genes that may play important roles in the viral integration process is understudied. The aim of this study was to examine the association between HPV16 and HPV18 viral integration status and SNPs in nonhomologous-end-joining (NHEJ) DNA repair pathway genes on cervical dysplasia. Women enrolled in two large trials of optical technologies for cervical cancer detection and positive for HPV16 or HPV18 were selected for HPV integration analysis and genotyping. Associations between SNPs and cytology (normal, low-grade, or high-grade lesions) were evaluated. Among women with cervical dysplasia, polytomous logistic regression models were used to evaluate the effect of each SNP on viral integration status. Of the 710 women evaluated [149 high-grade squamous intraepithelial lesion (HSIL), 251; low-grade squamous intraepithelial lesion (LSIL, 310 normal)], 395 (55.6%) were positive for HPV16 and 192 (27%) were positive for HPV18. Tag-SNPs in 13 DNA repair genes, including &lt;i&gt;RAD50&lt;/i&gt;, &lt;i&gt;WRN&lt;/i&gt;, and &lt;i&gt;XRCC4&lt;/i&gt;, were significantly associated with cervical dysplasia. HPV16 integration status was differential across cervical cytology, but overall, most participants had a mix of both episomal and integrated HPV16. Four tag-SNPs in the &lt;i&gt;XRCC4&lt;/i&gt; gene were found to be significantly associated with HPV16 integration status. Our findings indicate that host genetic variation in NHEJ DNA repair pathway genes, specifically &lt;i&gt;XRCC4&lt;/i&gt;, are significantly associated with HPV integration, and that these genes may play an important role in determining cervical cancer development and progression.&lt;/p&gt;Prevention Relevance:&lt;p&gt;HPV integration in premalignant lesions and is thought to be an important driver of carcinogenesis. However, it is unclear what factors promote integration. The use of targeted genotyping among women presenting with cervical dysplasia has the potential to be an effective tool in assessing the likelihood of progression to cancer.&lt;/p&gt;&lt;/div&gt;
The Effect of Width Modes on the Performance of MSSW Resonators (1984)

Theoretical and experimental investigations were performed to study width mode resonances (WMR) observed in magnetostatic surface wave straight edge resonators (MSSW-SER). It was found that for each principal resonance (n=1,2,3, m=l) of the MSSW-SER, different width mode resonances (m=2,3 ,... ) can be excited. Even and odd width modes can be excited depending on the RF current distribution in the microstrip transducers. Furthermore, all high order width mode resonances (m=2,3,4 ... ) occur at the low frequency side of the principal resonances (n=1,2,3, m=l). At high operating frequencies (e.g. above 4 CHz for pure YIC devices) the frequency separation between the principal resonances decreases and as a result, the width modes corresponding to high order principal modes will interfere with the low order principal modes. Through a careful choice of YIG and transducer parameters, the interference effects of width modes were minimized. Tunable high Q MSSW resonators with low insertion loss ( lOdB) have been designed and fabricated.
Non-transfusion-dependent thalassemias (2013)

Non-transfusion-dependent thalassemias include a variety of phenotypes that, unlike patients with beta (β)-thalassemia major, do not require regular transfusion therapy for survival. The most commonly investigated forms are β-thalassemia intermedia, hemoglobin E/β-thalassemia, and α-thalassemia intermedia (hemoglobin H disease). However, transfusion-independence in such patients is not without side effects. Ineffective erythropoiesis and peripheral hemolysis, the hallmarks of disease process, lead to a variety of subsequent pathophysiologies including iron overload and hypercoagulability that ultimately lead to a number of serious clinical morbidities. Thus, prompt and accurate diagnosis of non-transfusion-dependent thalassemia is essential to ensure early intervention. Although several management options are currently available, the need to develop more novel therapeutics is justified by recent advances in our understanding of the mechanisms of disease. Such efforts require wide international collaboration, especially since non-transfusion-dependent thalassemias are no longer bound to low- and middle-income countries but have spread to large multiethnic cities in Europe and the Americas due to continued migration.
Second by second prediction of solar power generation based on cloud shadow behavior estimation near a power station (2017)

Photovoltaic (PV) power generation has a particular problem for grid cooperation in that output can fluctuate due to the shadows created by clouds. If we can grasp the behavior of cloud shadows beforehand, then it may be possible to forecast output fluctuations. In this study, we want to prove if it is possible to calculate power output variation from the accumulated cloud shadow data. Cloud shadow behavior was measured from the ground by photodiodes (PDs) and the cloud shadow vector was calculated from the position and time difference. The time from the calculated cloud shadow vector to the arrival of the cloud shadow and the power generation output was calculated and compared with the actual solar power generation output. Thus, we confirmed that we can predict power generation output from a high correlation of two outputs. We found that prediction is possible, with high precision, at a short distance.
The New International Law Scholarship (2006)

This essay replies to criticisms advanced at a conference on our book, The Limits of International Law. We engage the critics on several methodological issues, we attempt to correct misimpressions about some of our arguments, and we reiterate our distinctive empirical claims. We also argue that our critics have more in common with us, and less in common with traditional international law scholars, than they are willing to admit. This observation leads us to claim that a new kind of international law scholarship is emerging, one that relies more heavily on social scientific attitudes and methodologies than the international law scholarship that it is gradually displacing. This trend fills us with optimism about the field, but at the same time we predict, with some misgiving, that much future scholarship will be preoccupied with reconciling the traditional liberal internationalism of the international law academy and the new imperative to use rigorous social scientific methods.
Reconstruction of pattern images from scanning electron microscope images (2005)

As the characteristic feature sizes of integrated circuits continue to shrink, both research and manufacturing are increasingly reliant on the scanning electron microscope (SEM) images. In this article, we propose a robust algorithm that automatically extracts the full edge contours from the SEM images and then converts the SEM images to pattern images even when the SEM images are corrupted by strong noise and lossy compression. This algorithm is expected to have many applications. An example of application—defect self-inspection—based on SEM conversion using this algorithm, is also shown.
Dimensions for Evaluating Cloud Resource Orchestration Frameworks (2016)

Despite the proliferation of cloud resource orchestration frameworks (CROFs), DevOps managers and application developers still have no systematic tool for evaluating their features against desired criteria. The authors present generic technical dimensions for analyzing CROF capabilities and understanding prominent research to refine them.
Abstract 2671: Structural analysis of the inhibitory mechanism of AP24534, a pan-BCR-ABL inhibitor overriding the T315I gatekeeper mutation (2010)

Abstract Although durable response in many chronic myeloid leukemia (CML) patients can be achieved by imatinib treatment, point mutations in the kinase domain of the BCR-ABL fusion protein can lead to drug resistance and relapse. Nilotinib and dasatinib, the two second generation Abl kinase inhibitors, are active against most imatinib resistant mutants with a few exceptions, particularly the T315I gatekeeper residue mutation. Using a structure-based approach we have identified AP24534, a molecule that potently inhibits the T315I mutant and all other mutants tested, thus acting as a pan-BCR-ABL inhibitor. To elucidate the basis for this unique profile of AP24534, we have used a combination of X-ray crystallographic and structure-activity relationship analysis on AP24534 and its analogs. The crystal structure of the T315I mutant Abl in complex with the inhibitor clearly demonstrates that AP24534 binds to Abl in a DFG-out binding mode with the ethynyl chemical moiety skirting the mutated gate-keeper residue avoiding steric clashes. The X-ray co-structures of both the wild type and the T315I mutant Abl, in conjunction with the SAR analysis, further reveal that AP24534 retains potency against the T315I and other imatinib-resistant ABL mutants through optimized multiple points of contact, balancing and distributing the overall binding affinity so that mutation-based disruption of one facet of the binding network results in only a slight reduction in binding affinity. Our structural analysis enables us to predict and rationalize the different degree of sensitivity of ABL point mutants to AP24534, and to understand how AP24534 can completely abrogate resistance in cell-based mutagenesis screens at relatively low concentrations. AP24534 is currently being investigated in a Phase I clinical trial in patients with refractory and resistant CML and other hematological malignancies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2671.
Macaiba palm: fatty and amino acids composition of fruits (2004)

"The lipid content of dried pulp and kernels of Acrocomia intumescens palm fruits grown in the Northeast region of Brazilwas determined to be about 34.6 and 49.2.6%, respectively. The hexane extracted oils from these parts showed refractive indices -1.4427 and 1.4310, specific gravity - 0.9012 and 0.9213, peroxide - 2.96 and 1.37, acid - 1.5 and 2.1, iodine - 77.1 and 18.0, andsaponification values - 158.0 and 230.4 respectively. Gas chromatography analysis showed a total of 24 and 18 fatty acids in pulp andkernel oils, respectively. The fatty acid composition of the pulp and kernel oils was 18.6 and 78.9% saturated, 65.5 and 20.0%monounsaturated 15.6 and 0.0% polyunsaturated, respectively. The principal saturated acids in pulp and kernel oil were palmitic andlauric acid with 13.3 and 45.5% of total fatty acids. Oleic acid was the predominant monounsaturated fatty acid in both oils with aconcentration of 63.2 and 19.7%, respectively. The amino acid profile of pulp proteins was superior to kernel proteins, but containedonly 49.5 of the methionine, 59.1 of he lysine and 96.2% of the valine found in the FAO reference protein. However, it containedleucine, isoleucine phenylalanine and threonine at 117, 136, 183 and 124% of the reference protein. The kernel proteins were deficientin essential amino acids with the exception of phenylalanine and isoleucine found at 156 and 101% of the reference protein,respectively"
ChemInform Abstract: ENANTIOSELECTIVE TRANSFER HYDROGENATION OF KETONES CATALYZED BY RHODIUM(I) COMPLEXES OF CHIRAL SCHIFF BASES (1983)

Abstract Das in situ aus dem Rhodium‐Komplex (III), (‐)‐2‐ Pyridinalphenylethylimin (IV) und KOH (V) gebildete Katalysator‐System katalysiert den Wasserstoff‐Transfer von Propan‐2‐ol (I) zu den prochiralen Ketonen (ll).
Optimization of the Averaging Reliability Technique Using Low Redundancy Factors for Nanoscale Technologies (2008)

This paper presents a method enabling the evaluation of the averaging fault-tolerant technique, using the output probability density functions of unreliable units that are acquired from Monte Carlo simulations. The method has been verified by comparing numerical simulations and analytical developments. A fault-tolerant four-layer architecture using averaging and with both fixed and adaptable threshold is compared with triple and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">R</i> -fold modular redundancy (RMR) techniques, at gate level and using fault-free decision gates, showing that the redundancy factor can be reduced by a factor of two to three using the proposed four-layer architecture, in replacement of RMR, thus enabling significant savings in the area, and power dissipation. The analysis of the reliability of averaging techniques together with the redundancy optimization has been performed for the first time in the context of a large-scale system, showing that a target reliability can be achieved with low redundancy factors (R < 8) for moderate defect densities (device failure rate up to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-5</sup> ). The performed analysis of the optimal size of the reliable islands (clusters) supports the assumption that clustering needs to be applied at the lower levels of design abstraction hierarchy, especially for fabrication technologies with increased defect density.
ChemInform Abstract: DETERMINATION OF OXIDES IN ALUMINUM BY MEANS OF MELT FILTRATION (1985)

Abstract Mit der neuentwickelten Methode, bei der 2.5 kg‐Proben induktiv aufgeschmolzen werden und durch einen 50 um‐Filter gefiltert werden, lassen sich Konzentration und Größen‐ Verteilung der Oxide lichtmikroskopisch und durch Röntgen‐Fluoreszenz bestimmen.
Observation of latch-up time evolution in CMOS IC's by means of SEM stroboscopic voltage contrast techniques (1987)

SEM stroboscopic voltage contrast techniques allow one to observe with high voltage resolution the temporal and spatial evolution of latch-up phenomena from the firing event to the final condition. In particular, the authors show by means of an example that in a CMOS IC the firing point may be different from the latch-up site in steady state. Only dynamic observations, therefore, allow a complete understanding of latch-up phenomena and an effective correction of IC layout.
Image reconstruction for structured-illumination microscopy with low signal level (2014)

We report a new image processing technique for the structured illumination microscopy designed to work with low signals, with the goal of reducing photobleaching and phototoxicity of the sample. Using a pre-filtering process to estimate experimental parameters and total variation as a constraint to reconstruct, we obtain two orders of magnitude of exposure reduction while maintaining the resolution improvement and image quality compared to a standard structured illumination microscopy. The algorithm is validated on both fixed and live cell data with results confirming that we can image more than 15x more time points compared to the standard technique.
Optimization for improved cellulase production of Penicillium funiculosum NCIM 1228 in submerged fermentation (2022)

<title>Abstract</title> The cellulase enzyme is currently the world's third-largest enzyme. Because of their demands in various industries like textiles, food, waste management, pharmaceuticals, agriculture, pulp paper, biofuels, etc., their demand curve shifts upward sharply. The response surface methodology (RSM) approach was employed to optimize media components and process parameters in the current investigation, which successfully increased cellulase production from Penicillium funiculosum NCIM 1228 ( P. funiculosum NCIM 1228). Statistical optimization for the hyperproduction of cellulases has been conducted using RSM. The Plackett-Burman design (PBD) approach was used to investigate the critical factors of the cellulase production medium, followed by the Box-Behnken design (BBD) method, which was used to statistically estimate optimum values and conditions that had a substantial impact on cellulase production. The estimated optimal combinations of parameters for cellulase production were urea (0.2, %), CaCl 2 (0.2, %), MgSO 4 (0.05, %), peptone (1.5, %), microcrystalline cellulose (5.0, %), wheat bran (2.5, %), CSL (2.5, %), KH 2 PO 4 (0.15, %), inoculum (10.65%), agitation (157 rpm), pH (5.88), and temperature (29.84°C). Conclusively, experimental validation under optimal conditions detected an increased production of 3.82-fold and 3.61-fold in filter paper activity (FPase) and β-glucosidase respectively while 1.66-fold and 1.57-fold improvement in FPase and β-glucosidase specific activity were observed. The xylanase activity was enhanced by 3.29-fold and its specific activity improved by 69.62% after optimization. P. funiculosum NCIM 1228 offers the benefit of producing cellulase with an entire cellulolytic system of enzymes that can be excreted extracellularly, which provides a promising biocatalyst for biofuel industries.
Design of a Chipless Harmonic Radar Temperature Sensor (2013)

Elongated SP might be another manifestation of enthesopaty in cervical spine of the spondyloarthropathies.
Augmenting legacy military ate for functional test using NxTest technology (2002)

Typical military Automatic Test Equipment (ATE) usually consists of a number of single channel stimulus and measurement devices connected to the UUT with a switch matrix, providing traditional serial, parametric test with its lengthy test times. Functional Test methodology tests a unit by simulating its environment and verifying that the unit operates correctly in that environment. This requires simultaneous stimulus and measurement capability that is not usually found in traditional military ATE. Boeing Support Systems is currently in the process of augmenting an existing military test station to provide functional test capability through the use of NxTest Technology. This paper will discuss our approach to adding Functional Test capability to an existing piece of equipment.
Dosimetry of iodine-131 ethiodol in the treatment of hepatoma. (1988)

The in vivo distribution and kinetics of [131I]Ethiodol injected through the hepatic artery have been measured on a group of four patients with hepatocellular carcinoma. The [131I]Ethiodol was distributed predominantly in the liver (70-90%) and lungs (10-20%) and was selectively concentrated and retained in the patients with massive and multinodular hepatomas with approximately 10% of the administered activity localizing in tumor. The radioactivity in the blood 2 hr postinjection was less than 0.1% and was never higher than 0.9% of the administered activity. The radioactivity cleared from normal liver tissue with an effective half-life of approximately 4 days while the clearance time from the tumor was 20-25% longer. Activity in the lungs initially increased and then cleared with a 5-day effective half-life. Based on these measurements, the estimated dose per mCi of [131I]Ethiodol administered is 31 rad to the liver, 22 rad to the lungs, 1.9 rad to the total body and 239 rad to a 4-cm diameter tumor. These results suggest that [131I]Ethiodol has the potential to deliver curative radiation doses to hepatomas with acceptable radiation burdens to normal tissues.
Room temperature emission from CdSe∕ZnSSe∕MgS single quantum dots (2007)

The authors report on room temperature photoluminescence from single CdSe quantum dots. The quantum dots, realized by self-organized epitaxial growth, are embedded in ZnSSe∕MgS barriers. The integrated intensity of the emission drops by less than a factor of 3 between 4K and room temperature. Microphotoluminescence with a spatial resolution of 200nm exhibits single dot emission that remains visible up to 300K. The linewidth of the single dot emission increases thereby from 340μeVto25meV at room temperature, which the authors attribute to the interaction of excitons with optical phonons.
Ketimine Intermediates in Amine-Catalyzed Enolization of Acetone1a (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKetimine Intermediates in Amine-Catalyzed Enolization of Acetone1aMyron L. Bender and Andrew WilliamsCite this: J. Am. Chem. Soc. 1966, 88, 11, 2502–2508Publication Date (Print):June 1, 1966Publication History Published online1 May 2002Published inissue 1 June 1966https://doi.org/10.1021/ja00963a026RIGHTS & PERMISSIONSArticle Views263Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (806 KB) Get e-Alertsclose Get e-Alerts