gebhart/patrepeval huggingface dataset:
Arrhythmia during insulin-induced hypoglycemia in a diabetic patient (1984)

• The temporal relationship between the level of blood glucose and the frequency of ventricular premature contractions (VPCs) during 24 hours was examined in a 45-year-old man with diabetes mellitus who was treated with a regular insulin injection. The number of VPCs increased sharply when the blood glucose level fell to about 50 mg/dL while the patient was awake. There was a minimal increase in VPCs during sleep, despite a decrease to 21 mg/dL in the blood glucose level. The insulin tolerance test produced frequent VPCs during hypoglycemia, which was suppressed by glucose administration. Changes in the level of plasma epinephrine correlated well with changes in the frequency of VPCs. These data suggest that increased levels of plasma epinephrine may have played a role in the genesis of VPCs that occurred during insulin-induced hypoglycemia. (<i>Arch Intern Med</i>1984;144:1068-1069)
Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 (2020)

The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the associated disease COVID-19, requires therapeutic interventions that can be rapidly identified and translated to clinical care. Traditional drug discovery methods have a >90% failure rate and can take 10-15 years from target identification to clinical use. In contrast, drug repurposing can significantly accelerate translation. We developed a quantitative high-throughput screen to identify efficacious agents against SARS-CoV-2. From a library of 1,425 FDA-approved compounds and clinical candidates, we identified 17 dose-responsive compounds with <i>in vitro</i> antiviral efficacy in human liver Huh7 cells and confirmed antiviral efficacy in human colon carcinoma Caco-2, human prostate adenocarcinoma LNCaP, and in a physiologic relevant model of alveolar epithelial type 2 cells (iAEC2s). Additionally, we found that inhibitors of the Ras/Raf/MEK/ERK signaling pathway exacerbate SARS-CoV-2 infection <i>in vitro</i>. Notably, we discovered that lactoferrin, a glycoprotein classically found in secretory fluids, including mammalian milk, inhibits SARS-CoV-2 infection in the nanomolar range in all cell models with multiple modes of action, including blockage of virus attachment to cellular heparan sulfate and enhancement of interferon responses. Given its safety profile, lactoferrin is a readily translatable therapeutic option for the management of COVID-19.
Metastasis to the Choroid of the Eye From Carcinoma of the Breast (1986)

<i>To the Editor</i>.—Traditionally, metastatic disease to the eye from any cancer has been thought to be a rare event. Many studies<sup>1,2</sup>spanning the past 20 years have found that 10% of patients with systemic breast cancer have choroidal metastatic lesions. These authors have concluded that metastases are the most common malignant tumors of the eye. As the following case report illustrates, recognition of choroidal metastasis is important so that proper therapy can be instituted to preserve vision. <i>Report of a Case</i>.—A 45-year-old woman was found to have an infiltrating ductal carcinoma of the breast and was treated with right modified radical mastectomy in August 1980. The tumor was pathologically stage I T1, NO, MO, and was estrogen receptor—and progesterone receptor—positive. Results of a funduscopic examination were reported to be normal. Two years later, the patient began to have blurred vision and distortion of the appearance
Prostaglandin E2 suppresses polyinosine-polycytidylic acid (polyI:C)-stimulated cytokine production via prostaglandin E2 receptor (EP) 2 and 3 in human conjunctival epithelial cells (2011)

Our results show that PGE(2) attenuated the expression of CCL5, CXCL10 and CXCL11 via both EP2 and EP3, and that the expression of IL-6 was attenuated only by EP3.
in situ Phosphorus-Doped Silicon Film Depositions by Magnetron Sputtering in Phosphorus Vapor (1985)

In situ phosphorus-doped silicon film deposition by sputtering in phosphorus vapor is presented. The phosphorus vapor is generated by heating solid red phosphorus in which the crucible is mounted in an rf planar magnetron sputtering system. Phosphorus is successfully in situ doped during deposition. Silicon films with phosphorus concentrations of up to 8.0×10 21 cm -3 are obtained by controlling the crucible temperature. It was found that the deposition rate increases with increasing crucible temperature.
COMPARATIVE BIOELECTRONIC DIAGNOSTICS OF THE ECOLOGICAL STATE OF POLLUTED WATER AREAS (ON THE EXAMPLE OF SOME CHANNELS OF THE VOLGA DELTA) (2021)

The objects of bioindication of the ecological state were 3 channels of the Volga Delta, located both directly in Astrakhan and in the Astrakhan region. The aim of the work was to conduct a comparative bioelectronic diagnosis of the ecological state of the selected channels with different local anthropogenic loads, both by type and size, based on assessments of the functional state (health) of the bivalve mollusks Anodonta anatina living in them, estimated on the basis of an analysis of their cardiorhythm, measured using an original fiber-optic bioelectronic system. It was found that shellfish selected from different water areas, after 1hour functional load, restore the original heart rate for different times, but in the range from 117 to 166 minutes, which is typical for shellfish living in significantly polluted reservoirs of the same ecological status - "Bad". This characteristic of the water areas completely coincides with the characteristic of the ecological state of the channels of the Volga River Delta specified in the State Report "On the state and on Environmental Protection of the Russian Federation in 2017". The authors proposed and justified the possibility of using the water area of the Gandurino River as a conditional reference for the Volga Delta region. In this case, according to the value of the environmental quality coefficient EQR, the channels of the Urban Branch and the Small Channel can be attributed to the regional environmental status - "Good".
Arginine Metabolism in Developing Soybean Cotyledons (1989)

The free and protein amino acid composition of Glycine max (L.) Merrill cotyledons was determined for the entire developmental period using high performance liquid chromatography. Arginine constituted 18% of the total protein nitrogen throughout development, and there was a linear arginine nitrogen accumulation rate of 1212 nanomoles per cotyledon per day between 16 and 58 days after anthesis. Arginine and asparagine were major constituents of the free amino acid pool, constituting 14 to 62% and 2 to 41% of the total free amino acid nitrogen, respectively. The urea cycle intermediates, citrulline, ornithine, and argininosuccinate were also detected in the free pool. A comparison of the amino acid composition of cotyledonary protein and of seedcoat exudate suggested that 72% of the cotyledon's arginine requirement is satisfied by in situ biosynthesis, and that 20% of the transformed nitrogen is incorporated into arginine. Also, [1-(14)C]glutamate and [U-(14)C]glutamine were fed to excised cotyledons. After 4 hours, (14)C was incorporated into protein and released as (14)CO(2), but none was incorporated into the C-1 and C-6 positions of free and protein arginine, determined using arginine-specific enzyme-linked assays. It is not currently known whether arginine biosynthesis in the cotyledon involves glutamate delivered from the mother plant or glutamate derived in situ.
ortho-Quinone Methide Imine: Generation and Diels-Alder Reaction at Room Temperature (1996)

Inter- and intramolecular Diels-Alder reaction of olefins with ortho-quinone methide imines generated in situ by BF3•Et2O provides an efficient synthesis of tetrahydroquinolines and other polycyclic nitrogen containing heterocycles.
2050 Decarbonisation of the Dutch Steelmaking Industry (2019)

Since the birth of industrial steelmaking in the Netherlands in 1918, the blast furnace production process has been used and is now capable of producing almost 7 million tonnes of crude steel annually. This level of steel production has brought significant employment and economic growth to the Netherlands, but has come at a cost to the environment. The Dutch steelmaking industry was responsible for producing 12.6 million tonnes of CO2 in 2017, making it the greatest CO2 emitting entity within Dutch industry. A broad range of technologies are being researched aiming to achieve deep decarbonisation of the steel sector. One of the most promising CO2-reducing technologies being developed directly uses electricity for the electrochemical reduction of iron oxide to produce iron, and ultimately steel. However, the high CO2-reduction potential is compromised by inhibiting significantly greater energy costs then other decarbonisation options. By 2050, the electricity system in the Netherlands is expected to be primarily based on renewable energy sources (RESs). The shift towards intermittent sources of electricity is expected to increase the fluctuation and uncertainty of electricity prices. The ability of electricity-based steelmaking technology to operate flexibly, with respect to its production rate, may aid in reducing overall energy costs. By responding to electricity prices, through ramping up and down of production, peak prices can be avoided and low prices can be capitalised on. Alongside the potential cost-saving, this may also serve to increase the integration of RESs. This study analyses the potential of flexible operation of such technology in the Netherlands based on two scenarios of the European electricity system in 2050. Based on these scenarios, it is found that for such technology to benefit from flexible operation, capital costs must inhibit some economies of scale, or be lower than anticipated, for electricity cost savings to outweigh additional capital costs of oversizing the steelmaking technology system. Relative to other European countries, the Netherlands is able to achieve greater electricity cost savings. This is likely due to the expected high penetration of offshore wind in 2050, which helps to provide more consistent periods of low-priced electricity due to its high annual capacity factor relative to other RESs.
Microcalorimetric Studies on the Interaction Mechanism between Proteins and Hydrophobic Solid Surfaces in Hydrophobic Interaction Chromatography:  Effects of Salts, Hydrophobicity of the Sorbent, and Structure of the Protein (2001)

This study examines the effects of different salts as well as the influence of the relative hydrophobicities of different sorbents on the adsorption processes of proteins in hydrophobic interaction chromatography (HIC). Comparative data acquired by the equilibrium binding analysis and by isothermal titration microcalorimetry (ITC) are presented. In particular, thermodynamic parameters, including the enthalpy changes, related to the interactions between several globular proteins and various Toyopearl 650 M sorbents under solvent conditions containing either 2.0 M ammonium sulfate or 2.0 M sodium sulfate at pH 7.0 and 298.15 K have been evaluated in terms of the molecular properties of these systems. The results reveal that the dependence of the free energy change, deltaGads, for protein adsorption to HIC sorbents on the salt composition can be mainly attributed to the enthalpy changes associated with protein and sorbent dehydration and hydrophobic interactions. Differences in binding mechanisms between the n-butyl- and phenyl-HIC sorbents were evident. In the latter case, the participation of pi-pi hydrophobic interactions leads to significant differences in the associated enthalpy and entropy changes. Furthermore, an increase in the hydrophobicity of either the sorbent or the protein resulted in more negative values for the free energy change, which arose mostly from dehydration processes. Entropic effects favoring HIC adsorption increased with an increase in the exposed nonpolar surface area of the protein. Consequently, an increased contribution from the entropy change to the respective change in free energy occurs when HIC sorbents or proteins of higher hydrophobicity are employed, with these larger entropy changes consistent with a change in the interaction mechanism from a binding event dominated by adsorption to a partitioning-like process. Data extracted from the ITC measurements also provided insight into the interaction mechanisms that occur between proteins and hydrophobic solid surfaces, yielding information that can be applied to the HIC purification of proteins according to the concept of critical hydrophobicity of the system and its thermodynamic consequences.
3 Protein-Protein Interactions and DNA Loop Formation (1990)

I. INTRODUCTION Recent studies of a number of prokaryotic operons have revealed that regulatory proteins bound at widely separated sites on the DNA can interact, thereby inducing the formation of a DNA loop. Such loops appear to play a critical role in the transcriptional regulation of several of these operons. DNA loop formation was first implicated in the regulation of the galactose and arabinose operons of Escherichia coli . In both cases, transcriptional repression was found to depend on operator sites located at considerable distances from the promoter regions, leading to the suggestion that repression was mediated by an interaction between repressors bound at widely separated sites. This chapter will begin with a description of a model system for studying DNA loop formation, the binding of λ repressor to artificially separated operator sites. This will be followed by a qualitative discussion of the energetics of loop formation. The last section will contain a review of several prokaryotic systems in which loop formation has been studied. II. DNA LOOP FORMATION BY λ REPRESSOR λ repressor binds cooperatively to adjacent operators on the phage chromosome (Johnson et al. 1979). That is, the presence of a strong repressor binding site adjacent to a weaker site increases the affinity of the weaker site for repressor. Consider, for example, the interaction of λ repressor with the right operator (O R ) in a λ lysogen (see Fig. 1a) (for review, see Ptashne 1986a). O R 1 binds repressor relatively tightly, whereas O R 2 and O R 3 each have an intrinsically weaker affinity...
No evidence for allelic association between schizophrenia and a functional variant of the human dopamine ?-hydroxylase gene (DBH) (1999)

Dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinepherine, has been proposed as being involved in the aetiology of schizophrenia. Previous work identified a functional polymorphism at nucleotide 910 of the DBH gene that results in a codon change in the mature protein Ala304Ser, with the mutant allele being associated with a lower enzymatic activity. In this study we performed an RFLP analysis in an association study consisting of 178 unrelated schizophrenic patients and 178 unrelated control subjects, matched for age, sex, and ethnicity. The frequency of the Ser304 DBH allele was 0.10 in the patient group and 0.08 in the control group, with no significant allelic or genotypic association observed. Therefore, we were unable to obtain evidence that this polymorphism contributes directly to susceptibility to schizophrenia.
Dissecting the role of the γ-subunit in the rotary–chemical coupling and torque generation of F 1 -ATPase (2015)

Unraveling the molecular nature of the conversion of chemical energy (ATP hydrolysis in the α/β-subunits) to mechanical energy and torque (rotation of the γ-subunit) in F1-ATPase is very challenging. A major part of the challenge involves understanding the rotary-chemical coupling by a nonphenomenological structure-energy description, while accounting for the observed torque generated on the γ-subunit and its change due to mutation of this unit. Here we extend our previous study that used a coarse-grained model of the F1-ATPase to generate a structure-based free energy landscape of the rotary-chemical process. Our quantitative analysis of the landscape reproduced the observed torque for the wild-type enzyme. In doing so, we found that there are several possibilities of torque generation from landscapes with various shapes and demonstrated that a downhill slope along the chemical coordinate could still result in negligible torque, due to ineffective coupling of the chemistry to the γ-subunit rotation. We then explored the relationship between the functionality and the underlying sequence through systematic examination of the effect of various parts of the γ-subunit on free energy surfaces of F1-ATPase. Furthermore, by constructing several types of γ-deletion systems and calculating the corresponding torque generation, we gained previously unknown insights into the molecular nature of the F1-ATPase rotary motor. Significantly, our results are in excellent agreement with recent experimental findings and indicate that the rotary-chemical coupling is primarily established through electrostatic effects, although specific contacts through γ-ionizable residue side chains are not essential for establishing the basic features of the coupling.
Pathologic findings from the national surgical adjuvant breast and bowel projects (NSABP) prognostic discriminants for 8-year survival for node-negative invasive breast cancer patients (1990)

Twenty-two pathologic features (including estrogen and progesterone receptors) and four clinical features observed in 950 women with node-negative Stage I invasive breast cancer who enrolled in the National Surgical Adjuvant Breast and Bowel Projects (NSABP) protocol B-06 were evaluated for their possible prognostic significance. Preliminary univariate analysis revealed ten characteristics that were significant in this regard at the 1% level. Their assessment in a Cox regression model demonstrated only three to be prognostically important; notable among these were nuclear grade, histologic tumor type, and race. Life-table plots revealed that 86% of patients whose cancers exhibited good nuclear grade survived for 8 years as opposed to 64% in whom the nuclear grade was scored as poor. Analyses demonstrated three prognostic categories for histologic tumor type. Patients with either mucinous, tubular, or papillary cancers fared significantly better than those having not otherwise specific (NOS) or atypical medullary tumors. Survival for those with typical medullary, NOS combinations, or lobular invasive cancers was intermediate. Blacks fared worse than whites. Survival was correspondingly better or worse when two favorable or unfavorable characteristics were detected. The number of black women in this cohort was considered too small for further subset analysis although generally the pattern of findings suggested that survival was worse for blacks than for whites in all subsets. A review, as well as our own experience, suggested that nuclear grade is as good if not better as a predictor of survival in node negative patients as information derived from DNA analyses, immunohistochemical demonstration of erb-B2 overexpression, and, possibly, the tumor labeling index at predicting survival in node-negative patients.
Supplementary Tables S1-S2 from Reduced Argininosuccinate Synthetase Is a Predictive Biomarker for the Development of Pulmonary Metastasis in Patients with Osteosarcoma (2023)

Supplementary Tables S1-S2 from Reduced Argininosuccinate Synthetase Is a Predictive Biomarker for the Development of Pulmonary Metastasis in Patients with Osteosarcoma
Hydrogenation of Esters to Alcohols Catalyzed by Defined Manganese Pincer Complexes (2016)

The first manganese-catalyzed hydrogenation of esters to alcohols has been developed. The combination of Mn(CO)<sub>5</sub> Br with [HN(CH<sub>2</sub> CH<sub>2</sub> P(Et)<sub>2</sub> )<sub>2</sub> ] leads to a mixture of cationic and neutral Mn PNP pincer complexes, which enable the reduction of various ester substrates, including aromatic and aliphatic esters as well as diesters and lactones. Notably, related pincer complexes with isopropyl or cyclohexyl substituents showed very low activity.
Nanostructured multi-block copolymer single-ion conductors for safer high-performance lithium batteries (2018)

Self-assembling, nanophase-separated multi-block copoly(arylene sulfone)s, selectively swelled with ethylene carbonate, provide excellent single-ion conductivity and cycling stability for high-energy lithium/Li[Ni<sub>1/3</sub>Co<sub>1/3</sub>Mn<sub>1/3</sub>]O<sub>2</sub> batteries.
Impact of post-remission therapy in patients aged 65-70 years with de novo acute myeloid leukemia: a comparison of two concomitant randomized ALFA trials with overlapping age inclusion criteria (2011)

In patients aged 65 to 70 years with de novo acute myeloid leukemia in complete remission after standard intensive induction chemotherapy, there is no apparent benefit from intensive post-remission therapy. (ClinicalTrials.gov Identifiers: NCT00931138 and NCT00363025).
In Hospital Outcomes of Total Hip Arthroplasty in the Medicaid Population. (2019)

Total hip arthroplasty (THA) is one of the most common orthopaedic procedures. This study's purpose was to evaluate national trends, patient demographics and hospital outcomes for Medicaid patients who underwent a primary THA. The National Hospital Discharge Survey (NHDS) database was queried for patients undergoing THA from 2001-2010. Patients were stratified into two groups based on insurance. We found from 2001-2005, Medicaid accounted for 2.38% of all THA performed, increasing insignificantly to 2.61% between 2006-2010. The Medicaid group was younger (50.3 vs. 65.6 years, p < 0.01). Length of stay was longer for the Medicaid group (4.6 vs. 4.0 days, p < 0.01). Medicaid patients were more likely to be discharged home (53.7% vs. 47.2%, p < 0.01) and less likely to be discharged to rehabilitation facilities (24.4% vs. 29.0%, p < 0.05). In conclusion, we discovered that the rate of Medicaid insurance in patients undergoing primary THA was stable through 2010, prior to the Affordable Care Act. We found Medicaid THA patients had longer length of stay, despite being a mean 15 years younger than the non-Medicaid cohort. Medicaid insurance status should be factored into risk adjustment models to avoid creating additional disincentive to treat the Medicaid population. (Journal of Surgical Orthopaedic Advances 28(4):281-284, 2019).
31‐1: Distinguished Paper: Measurement and Categorization of Alternate Subpixel Layout Near‐Eye Display Systems (2019)

We analyzed displays with alternate subpixel layouts to assess the effective detail size that they can reproduce. The measurements can then be used to classify the display to an appropriate XR system tier. Responsive application design can then tailor content for the best possible experience on each system tier.
Understanding genetic risk factors for AMD (2013)

A better understanding of how genetic risk factors influence the trajectory of age-related macular degeneration may be key to solving the puzzles of this disease. Ocular tissue research may play a role in that process.
Current status and clinical association of beta-catenin with juvenile nasopharyngeal angiofibroma (2016)

Although a beta-catenin association was seen in a subset of our sporadic juvenile nasopharyngeal angiofibroma cases, its expression was not homogeneous. This is in contrast to the Western literature that suggests a universal (homogenous) enhanced expression in the majority. Hence, further research is required to better define its molecular cascade.
Design and implementation of modularized 7-DOFs dual arm manipulator (2016)

This paper introduces the analytical inverse kinematic solution of modularized seven DOFs redundant manipulator with offsets at shoulder and elbow or wrist, and uses the analytical solution of manipulator to achieve dual arm intuitive teaching. Furthermore, this paper verify the method of select proper joint as redundant axis which could enhance the ability of obstacle avoidance in the corresponding workspace. Intuitive teaching and playing are successfully implemented to verify the prof-of-concept.