gebhart/patrepeval huggingface dataset:
Parathyroid MEN1 Gene Mutations in Relation to Clinical Characteristics of Nonfamilial Primary Hyperparathyroidism1 (1998)

Biochemical signs and severity of symptoms of primary hyperparathyroidism (pHPT) differ among patients, and little is known of any coupling of clinical characteristics of nonfamilial pHPT to genetic abnormalities in the parathyroid tumors. Mutations in the recently identified MEN1 gene at chromosome 11q13 have been found in parathyroid tumors of nonfamilial pHPT. Using microsatellite analysis for loss of heterozygosity (LOH) at 11q13 and DNA sequencing of coding exons, the MEN1 gene was studied in 49 parathyroid lesions of patients with divergent symptoms, operative findings, histopathological diagnosis, and biochemical signs of nonfamilial pHPT. Allelic loss at 11q13 was detected in 13 tumors, and 6 of them demonstrated previously unrecognized somatic missense and frameshift deletion mutations of the MEN1 gene. Many of the detected mutations would most likely result in a nonfunctional menin protein, consistent with a tumor suppressor mechanism. Clinical and biochemical characteristics of HPT were apparently unrelated to the presence or absence of LOH and the MEN1 gene mutations. However, the demonstration of LOH at 11q13 and MEN1 gene mutations in small parathyroid adenomas of patients with slight hypercalcemia and normal serum PTH levels suggest that altered MEN1 gene function may also be important for the development of mild sporadic pHPT.
E.L., a modern-day Phineas Gage: Revisiting frontal lobe injury (2022)

Fundação de Amparo Pesquisa Rio de Janeiro (FAPERJ), Universidade Federal do Rio de Janeiro (intramural), and Fiocruz/Ministery of Health (INOVA Fiocruz).
Några gymnasielärares syn på Kulturell mångfald – en studie med ett intersektionellt perspektiv (2008)

Studiens syfte är att se hur gymnasielärare på en skola i Västsverige ser på kulturell mångfald och hur de arbetar med det. Vi försöker även klargöra för begreppet intersektionalitet och användningen av det synsättet. Undersökningen bygger på en kvalitativ metod och insamlandet av material grundas på en semistrukturerad intervjuguide. Sju gymnasielärare intervjuades med spridda ämnesförankringar och verksamhets år. Resultatet av hur lärarna tolkar kulturell mångfald mynnade ut i etnicitet eftersom skolan upplevs segregerad av informanterna. Det framkom även att definitionen av begreppet kulturell mångfald var diffust och en anledning kan vara den framställning som finns i läroplanen för den frivilliga skolformen 1994.
Medical signal processing using the software monitor (2001)

The Software Monitor is a portable PC which is capable of processing and analysing in real time the vital physiological signals recorded non-invasively from healthy subjects or unwell hospital patients. Its main advantage is that it offers, in one intelligent monitor, the fusion of multiple sources of information. This makes it possible to track physiological instability (since unexpected combinations of changes are often an indication of deterioration) and to generate reliable alarms (since robustness is increased as a result of using multiple sources of information). In the current version of the Software Monitor, the following vital signs are being recorded: three channels of ECG (electrocardiogram), blood pressure using an inflatable cuff, oxygen saturation using pulse oximetry, respiration using impedance pneumography and skin temperature using a thermistor inside the blood pressure cuff. All of these signals are sampled at different rates (from the ECG which is sampled at 256 Hz to the blood pressure which is only measured two or three times per hour) but the data samples from each channel are given a timestamp which is synchronised with a master clock (Townsend and Tarassenko, 2000). The number of physiological signals could be increased if desired as this simply requires the appropriate sensor, associated electronics and a corresponding software module. The first application of the Software Monitor is in “high-dependency care” which is aimed at patients who are generally considered too ill to be satisfactorily cared for on the ordinary wards but who fail to meet admission criteria for Intensive Care. The provision of high-dependency care can improve clinical outcome and reduce the need for Intensive Care by detecting deterioration and intervening early in the clinical course of the disease process. However, a signScant bar to the provision of high-dependency care is the availability and cost of appropriately trained nursing and medical staff. The development of intelligent integrated monitoring offers a relatively inexpensive but effective method of improving patient surveillance and care.
Effect of Erosive Agents on Surface Characteristics of Nano-Fluorapatite Ceramic: An In-Vitro Study (2022)

Erosive beverages cause dissolution of natural teeth and intra-oral restorations, resulting in surface characteristic changes, particularly roughness and degradation. The purpose of this study was to evaluate the surface roughness and topography of a dental ceramic following immersion in locally available erosive solutions. A total of 160 disc specimens of a nano-fluorapatite type ceramic (12 mm diameter and 2 mm thickness) were fabricated and equally distributed into two groups (<i>n</i> = 80) and then evenly distributed among the following five testing groups (<i>n</i> = 16): lemon juice, citrate buffer solution, 4% acetic acid, soft cola drink, and distilled water which served as a control. The surface roughness (Ra) and topography were evaluated using a profilometer and scanning electron microscope at baseline, 24 h, 96 h, and 168 h respectively. Data were analyzed using ANOVA and Tukey's multiple comparisons (<i>p</i> ≤ 0.05). Surface changes were observed upon exposure to all acidic beverages except distilled water. Amongst all immersion media, 4% acetic acid produced the most severe surface roughness across all time periods (i.e., baseline, 24 h, 96 h, and 168 h). A statistically significant difference in the surface roughness values between all immersion media and across all four time intervals was observed. Erosive agents had a negative effect on the surface roughness and topography of the tested ceramic. The surface roughness increased with increased storage time intervals.
Methods of coronary and perfusion measurement (1990)

There obviously is a need to measure the coronary blood supply and to quantitate myocardial perfusion. Such measurements are more difficult in the human, but a number of useful techniques are being introduced for diagnosis and evaluation of treatments.
Equivalence of reflection paths of light and Feynman paths in stacked metasurfaces (2020)

We show the existence of virtual polarization states during the interaction of modes in metasurface stacks. In support of our findings we experimentally realize a metasurface stack, consisting of an isotropic layer of nanopatches and an anisotropic layer of nanowires. Utilizing an analogy to the interaction of electrons at junctions in mesoscopic electron transport via Feynman paths, we present a semi-analytic description of the modal interaction inside this stack. We then derive a series of all possible reflection paths light can take inside the metasurface stack.
Phase separation and self-assembly of cyclic amphiphilic block copolymers with a main-chain liquid crystalline segment (2015)

The effects of the macrocyclization of amphiphiles with a liquid crystalline segment were investigated in the solid state, and electric field-responsive cylindrical micelles and vesicles were self-assembled.
Navigation of Small and Lightweight Helicopter (2005)

A small battery-powered helicopter with a total weight of about 200 g and a rotor diameter of about 35 cm has been developed. Some indoor flights were performed without a human operator using a transmitter. The helicopter is capable of autonomous hovering flight near walls when IR range finders mounted on it are used to measure distances to walls and the floor. Four mounted photodetectors permit two maneuvers. In the first maneuver, the helicopter can follow a moving light. So it can be controlled simply by moving a light, and can follow a robot or a person carrying a light. In the second maneuver, the helicopter flying over a first light can fly towards a second light, when the first light is turned off and the second light is turned on. The position of the helicopter can be controlled by successively switching (on and off) lights in a row.
Abstract #5547: Enhancement of decitabine cytotoxicity by methoxyamine via inhibition of base excision repair (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

Decitabine (5aza-2\#8217;deoxycytidine) is a nucleoside analog used for the treatment of hematological malignancies. Previously, it was shown that the cytotoxic effect of low dose decitabine treatment is due to incorporation of its active metabolite, 5aza-2\#8217;deoxycytidine triphosphate, into DNA leading to inhibition of DNA methylation by binding irreversibly to DNA methyltransferases. We hypothesized that incorporated 5aza-2\#8217;deoxycytidine (or its deaminated analog, 5aza-2\#8217;deoxuridine) into DNA is also recognized and processed by the base excision repair (BER) pathway. In this case, inhibition of BER by methoxyamine (MX) would potentiate the cytotoxicity of decitabine. We evaluated role of BER in decitabine cytotoxicity in colon cancer, melanoma cells, and primary acute myelogenos leukemia (AML) cells. Decitabine-induced abasic sites (AP-sites) were increased proportionally with dose and duration of exposure. MX reduced the number of available AP-sites up to 80% indicating formation of stable MX-bound AP-sites that have the potential to interrupt BER pathway. A similar correlation between decitabine dose and the AP-sites formed was observed after in vitro exposure of primary AML cells to increase concentrations of decitabine. MX was able to bind a significant percentage (up to 60%) of these AP sites. Decitabine cytotoxicity was potentiated by MX. Cell survival assays demonstrate a 4-fold decrease in the IC50for decitabine when cells were co-treated with MX (IC50 dec = 4 \#956;M and IC50 Dec+ MX = 1 \#956;M). Apoptotic cell death measurements using Annexin V staining showed a 5-fold increase in cell death following decitabine and MX treatments. These events were accompanied by a concomitant increase in cleavage of PARP, and in \#947;H2AX. Moreover, MX enhanced decitabine-induced antitumor effect in mice bearing A375 human melanoma xenografts, as measured by tumor growth delay: 7 days (0.5 mg/kg decitabine) versus 14 days (0.5 mg/kg decitabine plus 2 mg/kg MX).These studies not only suggests for the first time the role of BER in the processing of incorporated decitabine, but they also provide insights into a new and promising cancer therapeutic strategy of combining decitabine with MX to block BER.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5547.
Unit commitment with wind generation accounting for transmission congestion (2010)

This paper proposes and efficient solution to the unit commitment (UC) schedule of a power system with wind generation including transmission limits. It does this by characterizing the residual demand feasibility set (loadability set) through a set of explicit linear inequalities. This set contains the residual demands that can be served by the available generation resources while also accounting for transmission limits. The UC is then solved by imposing an upper bound condition on the probability of the residual demand not being within the loadability set. This approach differs from the traditional one in that it does not model the numerous UC variables associated with the various wind power realizations as is the case in stochastic or deterministic security analysis.
Formation of self‐excited vibrations in wet rotor motors and their influence on the motor current (2003)

Abstract Research on condition monitoring for sensitive or process relevant drives has gained increasing importance in the latest past. The efforts made to reduce repairing costs and downtime led to the requirement of monitoring electrical drives. When doing so an important aspect is the detection of damages in an early state. Condition monitoring can be done by using various kinds of sensors and by analyzing stationary and non‐stationary signals. In some cases the use of vibration sensors for pump and motor protection and condition monitoring is difficult due to insufficient space and difficult environmental conditions, e.g. high water pressure. Submersible motor pumps for example are commonly working in deep wells down to 1000 meters. That is why motor current analysis remains as the only reliable monitoring method for condition monitoring and damage protection of submersible motor pumps. As one of the results of a highly interdisciplinary project this paper reports how the damage of the journal bearings of a wet rotor motor can be detected by motor current analysis. The investigations are bound on experimental measurements of two different types of centrifugal pumps with wet rotor motors.
Carbon quantum dot modified Na₃V₂(PO₄)₂F₃ as a high-performance cathode material for sodium-ion batteries (2020)

Sodium-ion batteries (SIBs) are broadly regarded as a promising alternative to lithium-ion batteries (LIBs) for application in grid-scale energy storage because of abundant resources and the low cost of sodium. Nevertheless, there still exist some challenges, including low energy density, unsatisfactory cycling stability, and sluggish ion transfer. Herein, carbon quantum dot modified Na₃V₂(PO₄)₂F₃ (NVPF@CQD) hierarchical microspheres were fabricated via a one-step solvothermal strategy followed by heat treatment. Furthermore, we systematically investigated how the solvothermal reaction time and content of carbon quantum dots influence the crystal structure, morphology and electrochemical performance, thereby obtaining the optimized final product. Impressively, the NVPF@CQD electrode presents awesome rate capability with a discharge capacity of 105.1 mA h g⁻¹ at 20C, i.e., 83% retention of its capacity at 0.2C. When cycled at a rate of 30C, the capacity retention is 90.2% after 6000 cycles, corresponding to a capacity fading of 0.0017% per cycle. Moreover, for practical applications, a sodium-ion full-cell configuration is constructed using the NVPF@CQD cathode and a commercial hard carbon anode exhibiting a high operating voltage and impressive cycling stability at 500 mA g⁻¹.
Consensus Based Overlapping Decentralized Estimator (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> In this technical note a new algorithm for state estimation is proposed in the form of a multi-agent network based on a synergy between local Kalman filters and a dynamic consensus strategy between the agents. It is shown that it is possible, under general conditions concerning local resources and the network topology, to achieve asymptotic stability of the whole estimation algorithm by a proper choice of the consensus gains. It is demonstrated that the consensus gains can be obtained by minimizing the total mean-square estimation error. Capabilities of the network to achieve reduction of the measurement noise influence are also discussed. </para>
Bacteremia due to Staphylococcus aureus in Patients with Cancer: Report on 45 Cases in Adults and Review of the Literature (1982)

The frequency, predisposing factors, therapy, and outcome of 45 episodes of bacteremia due to Staphylococcus aureus were reviewed in adult cancer patients. A poor performance status (i.e., patients largely bedridden), progressive neoplastic disease, and compromise of the mucocutaneous defense barriers characterized the patients with S. aureus sepsis. Seventeen patients died soon after the onset of infection: seven (16%) as direct result of staphylococcal sepsis, seven of factors unrelated to infection, and three of secondary sepsis due to gram-negative bacilli. The data presented here and reported by others indicated that (1) the incidence of staphylococcal sepsis in cancer patients has recently increased from a low point of 5% to a level as high as 30%; (2) breaches in the epithelium are the most important factors determining risk; (3) there are three effective approaches to therapy depending upon the clinical setting; and (4) the outcome appears to be determined by the status of the neoplastic disease and by early institution of appropriate antimicrobial therapy.
Calcium permeability changes and neurotransmitter release in cultured brain neurons. II. Temporal analysis of neurotransmitter release. (1985)

The coupling between depolarization-induced calcium entry and neurotransmitter release was studied in rat brain neurons in culture. The endogenous dopamine content of the cells was determined by high performance liquid chromatography utilizing electrochemical detection. The amount of dopamine in unstimulated cells was found to be about 16 ng/mg of protein. Depolarization of the neurons by elevated K+ caused a Ca2+-dependent release of dopamine from the cells. Following 1 min of depolarization, the cellular dopamine content and the amount of [3H]dopamine in cells preloaded with the radioactive transmitter were reduced by 35%. The release of [3H]dopamine by the neurons was measured at 1.5-6-s intervals by a novel rapid dipping technique. Depolarization in the presence of Ca2+ (1.8 mM) enhanced the rate of neurotransmitter release by 90-fold (0.072 +/- 0.003 s-1) over the basal release in the presence of Ca2+. The evoked release consisted of a major rapidly terminating phase (t1/2 = 9.6 s) which comprised about 40% of the neurotransmitter content of the cells and a subsequent slower efflux (t1/2 = 575 s) which was observed during following prolonged depolarization. Predepolarization of the cells in the absence of extracellular Ca2+ did not affect the kinetics of the evoked release. The fast evoked release could be re-elicited in the cells after 20 min "rest" in reference low K+ buffer. The effects of varying the extracellular Ca2+ concentrations on the kinetic parameters of the evoked release were measured. The amount of neurotransmitter released during the fast kinetic phase was very sensitive to the external Ca2+ (from 0% in the absence of Ca2+ to 40% of the neurotransmitter content at Ca2+ 0.3 mM). The rate constant of the fast release did not depend on the extracellular Ca2+, whereas the rate constant of the slow release increased from 0.0004 +/- 0.0001 s-1 at 0.4 mM Ca2+ to 0.0012 +/- 0.0002 s-1 at 0.8 mM Ca2+. The fast evoked release was inhibited by verapamil in a concentration-dependent manner. By contrast, verapamil enhanced the basal and the slow release independent of the presence of Ca2+. Both fast and slow phases of the evoked release were blocked by Co2+. Addition of Co2+ within the first 6 s after the onset of depolarization inhibited the fast release but failed to do so when added later on.(ABSTRACT TRUNCATED AT 400 WORDS)
Flexible Networks of Patterned Conducting Polymer Nanowires for Fully Polymeric Bioelectronics (2021)

Patterning of conducting polymers (CPs) into fully functioning devices remains a challenge for the creation of polymeric bioelectronics. Presently, the most successful method for patterning CPs is preprocess blending with structural components and using either subtractive or additive processes to produce the desired design. This work focuses on the development and characterization of a filter‐based processing method for direct pattern transfer of the CP poly(3,4‐ethylenedioxythiophene) (PEDOT) to elastomeric substrates. Laser sintering of a pattern into the surface of a filter membrane and the subsequent filtering of PEDOT nanowires onto the surface of the filter enable feature sizes of approximately 400 μm to be resolved without the need for any postprocessing. The resulting films of patterned PEDOT nanowires are found to possess high conductivity as well as improved wet electrochemical properties in comparison to platinum. Using the process developed in this work, thin and flexible arrays of PEDOT nanowire films are produced and used as an EMG device to test muscle contractions.
Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells (1997)

The production of subtle or conditional mutations in mice through the combined use of site-specific and homologous recombination has become an increasingly widespread experimental paradigm in mammalian genetics. Embryonic stem cells containing recombinase transgenes that were expressed in the male germ line, but not in other tissues or in the embryonic stem cells themselves, would substantially simplify the production of such alleles. Here we show that transgenes comprised of the mouse protamine 1 promoter and the Cre recombinase coding sequence mediate the efficient recombination of a Cre target transgene in the male germ line, but not in other tissues. Embryonic stem cell lines generated from one of these transgenic strains were transfected with targeting vectors that included loxP-flanked selectable markers, and homologously recombined alleles containing the marker and functional loxP sites were isolated. These results establish the potential of the system for substantially reducing the time, effort, and resources required to produce homologously recombined alleles in mice that have been secondarily rearranged by a site-specific recombinase.
CCR Translation for the Article from Ambulatory Monitoring Detects Sorafenib-Induced Blood Pressure Elevations on the First Day of Treatment (2023)

CCR Translation for the Article from Ambulatory Monitoring Detects Sorafenib-Induced Blood Pressure Elevations on the First Day of Treatment