gebhart/patrepeval huggingface dataset:
Thermodynamic Properties for the Solid−Liquid Phase Transition of Silybin + Poloxamer 188 (2009)

Mixtures of silybin (1) + poloxamer 188 (2) were prepared by a method of fusion cooling. Temperature (Tfus) and enthalpy of fusion (ΔfusH) versus mass fraction of silybin were measured by a DSC method. A eutectic point with w1 = 0.25 and Tfus,E = 325.4 K was observed. IR spectroscopy and X-ray powder diffraction results indicate that the spectra of mixtures can be regarded as the superposition of those of pure silybin and poloxamer 188. There was no significant change in the crystal structure of silybin and poloxamer in the mixed solid. The experimental Tfus, w1 diagram was fitted by using the Flory−Huggins model with a fair agreement.
Connecting macroscopic dynamics with microscopic properties in active microtubule network contraction (2017)

The cellular cytoskeleton is an active material, driven out of equilibrium by molecular motor proteins. It is not understood how the collective behaviors of cytoskeletal networks emerge from the properties of the network's constituent motor proteins and filaments. Here we present experimental results on networks of stabilized microtubules in Xenopus oocyte extracts, which undergo spontaneous bulk contraction driven by the motor protein dynein, and investigate the effects of varying the initial microtubule density and length distribution. We find that networks contract to a similar final density, irrespective of the length of microtubules or their initial density, but that the contraction timescale varies with the average microtubule length. To gain insight into why this microscopic property influences the macroscopic network contraction time, we developed simulations where microtubules and motors are explicitly represented. The simulations qualitatively recapitulate the variation of contraction timescale with microtubule length, and allowed stress contributions from different sources to be estimated and decoupled.
Anticancer Drugs Induce Caspase-8/FLICE Activation and Apoptosis in the Absence of CD95 Receptor/Ligand Interaction (1999)

Proteases of the caspase family are the critical executioners of apoptosis. Their activation has been mainly studied upon triggering of death receptors, such as CD95 (Fas/APO-1) and tumor necrosis factor-R1, which recruit caspase-8/FLICE as the most proximal effector to the receptor complex. Because apoptosis induced by anticancer drugs has been proposed to involve CD95/CD95 ligand interaction, we investigated the mechanism of caspase activation by daunorubicin, doxorubicin, etoposide, and mitomycin C. In Jurkat leukemic T cells, all drugs induced apoptosis and the cleavage of procaspase-8 to its active p18 subunit. However, cells resistant to CD95 were equally susceptible to anticancer drugs and activated caspase-8 with a similar kinetic and dose response as CD95-sensitive cells. The broad caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone prevented apoptosis and caspase-8 activation in response to CD95 and drug treatment, whereas a neutralizing CD95 decoy as well as a dominant-negative FADD construct selectively abrogated CD95, but not drug-induced effects. A potent activation of caspase-8 was also induced by cycloheximide, indicating that it was independent of protein synthesis. Our data, therefore, show that (1) anticancer drug-induced apoptosis does not require de novo synthesis of death ligands or CD95 interaction, and (2) that caspase-8 can be activated in the absence of a death receptor signaling.
Microsequence and mass spectral analysis of nonspecific cross-reacting antigen 160, a CD15-positive neutrophil membrane glycoprotein. Demonstration of identity with biliary glycoprotein (1993)

Sequence information was obtained from low picomole amounts of nonspecific cross-reacting antigen (NCA) 160 (M(r) 160,000), a granulocyte membrane glycoprotein. Following affinity purification and SDS-polyacrylamide gel electrophoresis, the protein was electrotransferred to nitrocellulose, digested with trypsin, and the peptides were isolated using capillary reversed-phase liquid chromatography. Analysis of these peptides by Edman microsequencing and mass spectrometry established that NCA-160 was identical to biliary glycoprotein I, a protein that we previously cloned from a human colon library (1). NCA-160 from human granulocytes is a CD15-positive glycoprotein belonging to the carcinoembryonic antigen family and possesses putative transmembrane and cytoplasmic domains. Previous efforts to characterize this antigen at the protein level were hampered by a blocked NH2 terminus. In this study, we confirmed 20% of the deduced amino acid sequence starting with approximately 50 pmol of sample. Carbohydrate structural data is also presented on a single N-linked oligosaccharide moiety located in the A' domain. The capillary high performance liquid chromatography techniques used here, as well as mass spectrometry, were essential for high sensitivity analysis of the blotted, digested glycoprotein.
Synthesis and Electrochemical Properties of Carbon-Coated Li2FeP2O7 for Li-Ion Batteries (2013)

Carbon-coated Li 2 FeP 2 O 7 (Li 2 FeP 2 O 7 -C) and Mg-doped Li 2 FeP 2 O 7 -C were succeccfully synthesized with pitch as a carbon source and Mg(C 2 O 4 )·2H 2 O as a Mg source, and the charge/discharge properties were compared with that of bare Li 2 FeP 2 O 7 . A thin carbon layer (ca. 5 nm in thickness) was coated on Li 2 FeP 2 O 7 powder after heat-treatment. Li 2 FeP 2 O 7 -C and Mg-doped Li 2 FeP 2 O 7 -C exhibited high discharge capacities of 97 and 104 mAh g -1 , respectively, at C/10 rate, implying a great improvement from that of bare Li 2 FeP 2 O 7 (69 mAh g -1 ). The cycleability and rate-capability were also improved by carbon-coating and Mg doping. Mg-doped Li 2 FeP 2 O 7 -C kept a high discharge capacity of 88 mAh g -1 even at 1 C rate. AC impedance analysis revealed that Mg-addition suppresses excess electrolyte decomposition on the surface of Li 2 FeP 2 O 7 and reduces the resistance of SEI.
Effects ofProcessing Conditions on Prototypes Reinforced with TLCPs for Fused Deposition Modeling (2018)

Polypropylene (PP) composite strands, reinforced with thermotropic liquid crystalline&#13;\npolymers (TLCPs), were generated using a novel dual extrusion process which allowed for&#13;\nthe use of a TLCP with a significantly higher melting temperature than that of the PP.&#13;\nPregenerated TLCPtpp microcomposite strands were reprocessed using a second novel&#13;\nprocess to produce a wen-controned monofilament composite for use in a FDM 1600&#13;\nrapid prototyping system in order to build complex geometries. Uniaxial parts were built&#13;\nto determine the effect of differing material compositions and processing temperatures, in&#13;\norder to develop an oPerating window for the optimal mechanical properties. By&#13;\nadjusting the lay down pattern of orientable materials, the final mechanical properties of&#13;\nthe part could be engineered independent ofthe material. To understand the effect ofthe&#13;\nreprocessing steps on the pregenerated microcomposites, the final mechanical properties&#13;\nofthe monofilament composite were compared with those ofthe pregenerated strands.
[Analysis of susceptibility genes in sarcoidosis]. (1994)

In order to investigate immunogenetic mechanisms in the pathogenesis of sarcoidosis, sixty-three patients with sarcoidosis, who were diagnosed histologically, were tested for HLA antigens. Controls consisted of 120 healthy subjects. A lymphocyte cytotoxicity test was used for typing HLA-A, -B, -C, -DQ and -DR antigens. HLA-DP genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The frequencies of HLA-DR52 and its associated antigens (HLA-DR5, -DR6 and -DR8) were significantly increased in the patients as compared to the control subjects. On the contrary, the frequencies of HLA-DR53, -DR1, and -DR4 were significantly decreased in the patients. The frequency of HLA-DPB1*0402 was significantly lower in the patients. No significant differences were observed in HLA-DQ antigens. These results suggest that HLA-DR52 associated antigens contribute to the susceptibility to sarcoidosis in Japanese.
Penalized partial likelihood for sequential order selection (2002)

We have previously shown that partial likelihood estimation of finite normal mixtures (FNM) yields very efficient estimators and hence provides a very attractive solution for real-time signal processing. Order selection, however, is a very important factor affecting the overall performance. We address the problem of order selection for the FNM model in applications requiring sequential processing. We pose the problem as the joint determination of the system memory and the observation vector dimension which together determine the number of mixture components. We define penalized partial likelihood as the information theoretic criterion for order selection and propose a sequential order selection procedure. We consider channel equalization as an example, an application for which FNM provides a perfect match to the data generation mechanism and hence is a particularly attractive solution. We study examples in channel equalization showing the effectiveness of the approach and discuss its properties.
miR than meets the eye: Figure 1. (2011)

Retinoblastoma is a rare pediatric cancer that has served as a paradigm to investigate the mechanisms of tumorigenesis. In this issue of Genes & Development, Conkrite and colleagues (pp. 1734-1745) found high levels of the miR-17~92 and miR-106b-25 microRNAs in primary retinoblastomas and show that overexpression of miR-17~92 accelerates retinoblastoma development in mice by promoting proliferation, in part by reducing expression of the cell cycle inhibitor p21. These experiments identify the RB/miR-17~92/p21 axis as a critical regulator of retinoblastoma tumorigenesis and potentially many other cancers.
Experimental characterization and prediction of forming limit diagrams of PHS1800 during hot stamping (2023)

Abstract The use of press-hardening steels (PHSs) in automotive bodies creates the opportunity of producing thinner, higher-strength components. PHS1800, an Al-Si coated PHS grade with ultimate tensile strength of around 1.8 GPa after hot stamping, is a candidate material for vehicle anti-intrusion applications. The current study aims to investigate the formability of this steel during the hot-stamping process. A custom Marciniak punch test and in situ digital image correlation (DIC) techniques were used to determine the in-plane forming limits of this steel during quenching from an austenitic temperature. The carrier blank thickness and geometry were exploited to quench the surrounding material of the specimens while promoting localization in their central regions. Approximately linear strain paths ranging from uniaxial to biaxial stretching were obtained in the tests while avoiding friction and out-of-plane bending. The forming limit curves (FLCs) of the material under various hot-stamping conditions were then predicted using the Marciniak-Kuczyński (MK) model, taking into account the temperature and strain-rate histories. The predicted limit strains were in good accord with the measured data.
SiGe track-and-hold with HD 3 =-87 dBFS for f ck =110 MHz, f in =(110 MHz-1 kHz) and V in =1 V pp,diff (2000)

This paper relies on the design of an high-performance Track-and-Hold, intended to be used in data converters for telecommunication applications. Because of the challenging performance requirements an advanced SiGe bi-polar technology (f T = 75 GHz) has been used to implement the circuit. T&H measurements show a third harmonic better than -87 dBFS with a 1 V pp,diff input level, 110 MHz - 1 kHz signal frequency, and 110 MHz clock rate. Current consumption is 25 mA @ 5 V supply (not including the low-jitter clock buffer). The other performance are at the state-of-the-art.
An alternate synthesis of 6‐substituted‐5‐deazapteridines (1982)

Abstract A procedure for synthesis of 2,4‐diamino‐6‐substituted‐5‐deazapteridines (pyrido[2,3‐ d ]pyrimidines) is described. Condensation of 1‐piperidino‐1‐propene with ethoxymethylenemalononitrile afforded an enamino malononitrile adduct, which when treated with ammonia yielded 2‐amino‐3‐cyano‐5‐methylpyridine. Cyclization to 2,4‐diamino‐6‐methyl‐5‐deazapteridine could be effected with guanidine. Similar condensation of piperidinopropene with ethyl methoxymethylenecyanoacetate followed by cyclization with hydroxylamine gave 2‐amino‐3‐carbethoxy‐6‐methylpyridine 1‐oxide. Reduction with phosphorus trichloride afforded the pyridine base, however, attempts to cyclize the amino ester to 2‐amino‐4‐hydroxy‐6‐methyl‐5‐deazapteridine were unusccessful.
A differential zero-correction amplifier (1973)

The maintenance of a constant equivalent input offset voltage with time and temperature is one of the most difficult problems in direct-coupled amplifiers. An improved zero-correction technique is used to realize a differential amplifier with a very low input offset voltage.
Metal complex SERMs (selective oestrogen receptor modulators). The influence of different metal units on breast cancer cell antiproliferative effects (2005)

The selective oestrogen receptor modulator tamoxifen is a leading agent in the adjuvant treatment of breast cancer. Several organometallic moieties have been vectorised with tamoxifen, in order to improve on the latter's antiproliferative properties by the addition of a potentially cytotoxic moiety, and have been evaluated versus both oestrogen receptor positive (MCF7) and oestrogen receptor negative (MDA-MB231) breast cancer cells. For tamoxifen analogues with ((R,R)-trans-1,2-diaminocyclohexane)platinum(II), cyclopentadienyl rhenium tricarbonyl, and ruthenocene tethers, there was no enhancement of the antiproliferative effect on oestrogen receptor positive cells, nor any cytotoxic effect on oestrogen receptor negative cells, while those containing cyclopentadienyl titanium dichloride showed an oestrogenic effect. However, compounds where ferrocene replaces tamoxifen's phenyl ring were strongly cytotoxic against both cell lines. The synthesis and biological results of these compounds is reviewed and placed in the historic context of inorganic compounds in therapy.
Vagococcus elongatus sp. nov., isolated from a swine-manure storage pit (2007)

A polyphasic taxonomic study was performed on an uncharacterized Gram-positive, catalase-negative, elongated coccus-shaped bacterium isolated from a swine-manure storage pit. The bacterium, designated strain PPC9(T), was facultatively anaerobic and had a DNA G+C content of 44.5 mol%. Comparative 16S rRNA gene sequencing indicated that the bacterium represented a novel subline within the genus Vagococcus, close to but distinct from Vagococcus lutrae. Strain PPC9(T) was readily distinguished from the five recognized species of the genus Vagococcus by using biochemical tests and molecular genetic analysis. Based on phylogenetic and phenotypic evidence strain PPC9(T) is considered to represent a novel species of the genus Vagococcus, for which the name Vagococcus elongatus sp. nov. is proposed. The type strain is PPC9(T) (=CCUG 51432(T)=NRRL B-41357(T)).
A Reflection on Biomedical Engineering Ethics Education from Multiple Perspectives (2013)

In this paper, we discuss biomedical engineering ethics education by interweaving perspectives from a student, instructors, a biomedical engineer in the workplace, and a medical physicist.
Synthesis of binocular disparity with motion parallax in depth slant perception: Statistical efficiency approach. (2002)

Statistical efficiency approach is used in order to investigate sampling properties of both binocular disparity and motion parallax processes in depth slant perception and to examine the independent decisions model (Mulligan & Shaw, 1980) consisting of these processes. We carried out two experiments in which each cue was displayed solely (i.e., single condition) and both cues were displayed simultaneously (i.e., multiple condition). A two-alternative forced-choice (2AFC) task was used under the situation where a Gaussian noise was added to the stimulus value of depth slant. Statistical efficiencies were calculated in each experiment. The results showed that sampling size from binocular disparity was at least comparable or larger by a factor of 2.5-3.5 with that from motion parallax and that efficiencies of the multiple condition considerably exceeded those of the single condition. This suggests invalidity of the independent decisions model.
Rab30 is required for the morphological integrity of the Golgi apparatus (2011)

Taken together, these data illustrate that Rab30 primarily localises to the Golgi apparatus and is required for the structural integrity of this organelle.
The new structure of an operating system (1992)

This paper proposes the new structure for an operating system in an open and mobile computing environment. The structure is characterized by object/metaobject separation, metahierarchy, and object migration. We then present the practical implementation of the Apertos operating system based on the proposed structure, where reflectors are introduced for metaobject programming and MetaCore for providing the common primitives. We also present some measurement results of the Apertos operating system.
ChemInform Abstract: A New Route to Trienals Using 2‐Substituted 2H‐Pyran‐Based Wittig Reagents. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Security of Indirect-Authenticated Key Exchange Protocol (2009)

Security issues play an important role in modern communication worlds. Via distrusted networks, exchanged messages need to be encrypted by a session key for security requirements. Session keys are preferred to be generated by communication parties, and how to authenticate the other communication party is an important problem needed to be solved. In three-party encrypted key exchange (3PEKE) protocols, a special type of indirect-authenticated protocols, a trusted third party is involved to have two communication parties be able to authenticate each other and negotiate one session key. In 2008, Yoon and Yoo proposed a three-party encrypted key exchange protocol and claimed their protocol provides a more secure way for exchanging messages. Unfortunately, we find that their protocol suffers from undetectable one-line password guessing attacks. In this manuscript, we first review the important related works and show how to mount attacks on Yoon and Yoo's 3PEKE protocol.
Feasibility and safety of retroperitoneoscopic laparoendoscopic single‐site nephrectomy: technique and early outcomes (2011)

• Retroperitoneoscopic LESS nephrectomy using the GelPOINT apparatus as an access platform is feasible and safe. • It provides adequate flexibility and spacing of port placements as well as acceptable operative outcomes. • It is especially valuable for those patients who need to maintain peritoneal integrity or those with an abnormal or obliterated peritoneal space.
Multifunctional Nanostructures and Nanopocket Particles Fabricated by Nanoimprint Lithography (2019)

Nanostructured surfaces and nanoparticles are already widely employed in many different fields of research, and there is an ever-growing demand for reliable, reproducible and scalable nanofabrication methods. This is especially valid for multifunctional nanomaterials with physical properties that are tailored for specific applications. Here, we report on the fabrication of two types of nanomaterials. Specifically, we present surfaces comprising a highly uniform array of elliptical pillars as well as nanoparticles with the shape of nanopockets, possessing nano-cavities. The structures are fabricated by nanoimprint lithography, physical and wet-chemical etching and sputter deposition of thin films of various materials to achieve a multifunctional nanomaterial with defined optical and magnetic properties. We show that the nanopockets can be transferred to solution, yielding a nanoparticle dispersion. All fabrication steps are carefully characterized by microscopic and optical methods. Additionally, we show optical simulation results that are in good agreement with the experimentally obtained data. Thus, this versatile method allows to fabricate nanomaterials with specific tailor-made physical properties that can be designed by modelling prior to the actual fabrication process. Finally, we discuss possible application areas of these nanomaterials, which range from biology and medicine to electronics, photovoltaics and photocatalysis.
Complete Genome Sequence of Mycobacterium sp. Strain 3519A (2018)

<i>Mycobacterium</i> sp. strain 4858 is a nontuberculous mycobacterium isolated from sputum in a Cambodian patient with a pulmonary infection. We report the first complete 5.6-Mbp-long genome sequence of <i>Mycobacterium</i> strain 4858, with 68.24% GC content, carrying 5,255 protein-coding genes, 47 tRNAs, and 3 rRNA genes.
Shaped Charge Selection and Underbalance Optimization Using the Perforation Flow Laboratory for Deepwater Subsea Wells in Offshore Africa (2014)

In recent years, the oil and gas perforating industry has seen the growth of perforating flow laboratories to develop shaped charges for reservoir-specific conditions. Flow laboratories can help measure perforation tunnel characteristics, flow features, productivity and the performance of shaped charges. Such information is critical to perforating job design, particularly in challenging deepwater wells. In this study, we are focused on a deepwater subsea sandstone field (1000-1700m water depth) in offshore Africa. The fields typically consist of sinuous turbidite sandstone channel systems of Turonian age. The wells are completed as cased and perforated completions with no active sand control. Typically, deepwater cased and cemented completions are frac-packed, which reduces reliance on perforating performance for efficient flow path from the reservoir into the wellbore. The completion design in this case relies heavily on effective perforations for an efficient flow path, including perforating past drilling damage and minimizing the risk of sand production through selective perforating and reduced shot density. The formation properties were evaluated to select an analogous rock for implementing a comprehensive testing program. In the first phase, a series of API RP19-B Section IV tests were conducted using various shaped charges to obtain a baseline understanding of shaped charge performance. The rock was stressed to simulate reservoir conditions of overburden, reservoir and wellbore pressures. The testing program aimed at selecting an optimal shaped charge and ensuring the maximum clean up/productivity that can be achieved based on the underbalance method. In addition, the test results provided insight into tunnel geometry, inflow performance and dynamic pressure data to develop an informed perforating strategy. Subsequently, the second phase of the program evaluated the effects of mud invasion on perforation geometry and the higher magnitude of static underbalance on perforation cleanup. This study demonstrates how the perforating flow laboratory can be utilized to design perforating jobs in a deepwater environment. The flow laboratory serves as a unique tool to measure and optimize shaped charge performance in a wide variety of downhole scenarios.
Loops in reeb graphs of 2-manifolds (2003)

Given a Morse function f over a 2-manifold with or without boundary, the Reeb graph is obtained by contracting the connected components of the level sets to points. We prove tight upper and lower bounds on the number of loops in the Reeb graph that depend on the genus, the number of boundary components, and whether or not the 2-manifold is orientable. We also give an algorithm that constructs the Reeb graph in time O(nlogn), where n is the number of edges in the triangulation used to represent the 2-manifold and the Morse function.