gebhart/patrepeval huggingface dataset:
Amino acid digestibility and energy concentration of high-protein corn dried distillers grains and high-protein sorghum dried distillers grains with solubles for swine12 (2010)

A study was conducted to determine the AA digestibility and energy concentration of a specialized high-protein corn distillers dried grains (HPC-DDG) product and a high-protein sorghum dried distillers grains with solubles (HPS-DDGS) product. Six growing barrows (BW = 22.7 kg) were surgically fitted with T-cannulas at the terminal ileum and allotted randomly to 3 treatments in a crossover design with 3 periods. The treatment diets were 1) 67% HPC-DDG and 2) 50% HPS-DDGS as the sole protein sources, and 3) an N-free diet for determining basal endogenous AA loss. All diets contained 0.25% chromic oxide as an inert marker. Digesta and fecal samples were collected and analyzed for AA and energy concentrations. After chemical analysis, standardized and apparent ileal digestible (SID and AID, respectively) AA and GE were determined for each coproduct. The DE, ME, and NE values for HPC-DDG and HPS-DDGS also were calculated. The chemical composition of HPC-DDG and HPS-DDGS on a DM basis was 40.8% CP, 5.4% fat, 22.9% ADF, 36.6% NDF, 0.04% Ca, and 0.42% P and 48.2% CP, 3.1% fat, 17.5% ADF, 20.4% NDF, 0.13% Ca, and 0.82% P, respectively. The DM content of HPC-DDG and HPS-DDGS was 89.50 and 91.88%, respectively. Analyzed AA content of HPC-DDG was greater than that of traditional corn DDGS. The Lys content of HPC-DDG was 1.36% (DM basis), resulting in a Lys-to-CP ratio of 3.2%. In HPS-DDGS, most AA were present in greater proportions than in HPC-DDG or conventional sorghum DDGS. The HPS-DDGS Lys content was 1.7% (DM basis), equivalent to a Lys-to-CP ratio of 3.5%. In HPC-DDG, the AID for Lys, Met, Thr, and Trp were 65.9 ± 1.7, 87.0 ± 1.9, 72.8 ± 3.4, and 76.2% ± 3.5, respectively, and SID values were 67.8 ± 1.7, 87.5 ± 1.9, 75.0 ± 3.5, and 78.6 ± 3.7%, respectively. For HPS-DDGS, the AID for Lys, Met, Thr, and Trp were 51.9 ± 5.3, 73.0 ± 3.1, 60.6 ± 5.3, and 71.7 ± 3.4%, respectively, and SID values were 53.7 ± 4.9, 73.8 ± 3.0, 63.0 ± 4.9, and 73.8 ± 3.0%, respectively. The GE, DE, and calculated ME and NE values were 5,293, 3,703 ± 121, 3,426 ± 121, and 2,131 ± 88 kcal/kg of DM, respectively, for HPC-DDG and 5,108, 3,878, 3,549, and 2,256 kcal/kg of DM, respectively, for HPS-DDGS. Results indicate that both coproducts are well suited for use in swine diets and that actual AA digestibility values and calculated energy concentrations can now be used in swine diet formulation.
Global mean first-passage times of random walks on complex networks (2009)

We present a general framework, applicable to a broad class of random walks on complex networks, which provides a rigorous lower bound for the mean first-passage time of a random walker to a target site averaged over its starting position, the so-called global mean first-passage time (GMFPT). This bound is simply expressed in terms of the equilibrium distribution at the target and implies a minimal scaling of the GMFPT with the network size. We show that this minimal scaling, which can be arbitrarily slow, is realized under the simple condition that the random walk is transient at the target site and independently of the small-world, scale-free, or fractal properties of the network. Last, we put forward that the GMFPT to a specific target is not a representative property of the network since the target averaged GMFPT satisfies much more restrictive bounds.
Evaluation of the structural capacity of rigid pavements at the network level (2018)

Pavement surface deflection has been used by researchers and highway agencies to assess the structural condition of the pavement structure. None of the currently available approaches provides an acceptable evaluation method for the rigid pavement structural capacity at the network level. In this research, pavement structural ratio (PSR) and overall pavement structural index (OPSI) were derived from deflection bowls generated from finite element simulations and validated by actual field deflection data measured by falling weight deflectometer and performance data extracted from long-term pavement performance database. The PSR parameter provides structural evaluation of the rigid pavement slab and the base course above the subgrade only. Whereas, OPSI parameter provides an overall evaluation of the pavement structure and the subgrade.
Probabilistic Completeness of Randomized Possibility Graphs Applied to Bipedal Walking in Semi-unstructured Environments (2017)

We present a theoretical analysis of a recent whole body motion planning method, the Randomized Possibility Graph These routes are then examined by lowerlevel planners to determine feasibility. In this paper, we show that this approach is probabilistically complete for bipedal robots performing quasi-static walking in "semi-unstructured" environments. Furthermore, we show that the decomposition into higher and lower level planners allows for a considerably higher rate of convergence in the probability of finding a solution when one exists. We illustrate this improved convergence with a series of simulated scenarios.
Un outil de reconnaissance géophysique en milieu urbain : la prospection électrostatique (2002)

La prospection géophysique en milieu urbain souffre de différentes difficultés : vibrations, bruits électrique et électromagnétiques, structure superficielle complexe et présence d’ouvrages. Pour explorer les dix premiers mètres, la méthode électrostatique peut remplacer la méthode électrique à courant continu pour fournir une image des structures du sous-sol en utilisant les mêmes outils d’interprétation.
Small Ring Building Blocks for Organic Synthesis. Part 110. Domino Heck—Diels—Alder Reactions of Differently Substituted Cyclopropylallenes. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Extended Förster theory of donor–donor energy migration in bifluorophoric macromolecules Part II. Method for determining intramolecular distances with experimental validation using mono and bifluorophoric systems (2000)

Recently an approximate theory was presented and applied for determining intramolecular distances in proteins. The rate of donor–donor energy migration (DDEM) is extracted and analysed from fluorescence depolarisation experiments by means of the DDEM model (Karolin et al., Biophys. J., 1998, 74, 11; Bergström et al., Proc. Natl. Acad. Sci., 1999, 96, 12477). Previously an extended Förster theory (EFT) was derived (Johansson et al., J. Chem. Phys., 1996, 105, 10896), which accounts for DDEM between reorienting molecules. For the first time, this rigorous theory is applied for analysing time-resolved fluorescence depolarisation data, accumulated by using the time-correlated single photon counting (TCSPC) technique. A simulation–deconvolution algorithm is presented which reduces the need of the DDEM model (Edman et al., Phys. Chem. Chem. Phys., 2000, 2, 1789), and other approximate theories (Edman et al., Mol. Phys., submitted). Two bifluorophoric systems were studied, namely; 1,32-dihydroxy-dotriacontane-bis(rhodamine) 101 ester solubilised in lipid vesicles, and bis(9-anthrylmethyl-phosphonate) bisteroid dissolved in propane-1,2-diol. The bis-rhodamine molecules span across lipid bilayers, so that the two rhodamine moieties of the molecule are localised on opposite sides of a bilayer. From the analyses of the fluorescence anisotropy, the donor–donor distances were determined to be 36.5±1 and 21.0±1.5 Å, for the membrane spanning molecule and the bisteroid, respectively. The results are in good agreement with independent studies.
Single-crystal EPR spectra of copper-manganese bimetallic ferrimagnetic chains (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSingle-crystal EPR spectra of copper-manganese bimetallic ferrimagnetic chainsDante Gatteschi, Olivier Guillou, Claudia Zanchini, Roberta Sessoli, Olivier Kahn, Michel Verdaguer, and Yu PeiCite this: Inorg. Chem. 1989, 28, 2, 287–290Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/ic00301a027https://doi.org/10.1021/ic00301a027research-articleACS PublicationsRequest reuse permissionsArticle Views178Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spinal cord compression with paraparesis in ovarian cancer patient (2010)

Spinal cord compression is fatal condition to oncologic patients. Metastatic spinal cord compression from ovarian cancer is rarely reported in the literature. We experienced a case of solitary spinal cord compression with paraplegia in recurrent ovarian cancer patients.
MHC-II-Independent CD4+ T Cells Induce Colitis in Immunodeficient RAG−/− Hosts (2001)

CD4(+) alpha beta T cells from either normal C57BL/6 (B6) or MHC-II-deficient (A alpha(-/-) or A beta(-/-)) B6 donor mice engrafted into congenic immunodeficient RAG1(-/-) B6 hosts induced an aggressive inflammatory bowel disease (IBD). Furthermore, CD4(+) T cells from CD1d(-/-) knockout (KO) B6 donor mice but not those from MHC-I(-/-) (homozygous transgenic mice deficient for beta(2)-microglobulin) KO B6 mice induced a colitis in RAG(-/-) hosts. Abundant numbers of in vivo activated (CD69(high)CD44(high)CD28(high)) NK1(+) and NK1(-) CD4(+) T cells were isolated from the inflamed colonic lamina propria (cLP) of transplanted mice with IBD that produced large amounts of TNF-alpha and IFN-gamma but low amounts of IL-4 and IL-10. IBD-associated cLP Th1 CD4(+) T cell populations were polyclonal and MHC-II-restricted when derived from normal B6 donor mice, but oligoclonal and apparently MHC-I-restricted when derived from MHC-II-deficient (A alpha(-/-) or A beta(-/-)) B6 donor mice. cLP CD4(+) T cell populations from homozygous transgenic mice deficient for beta(2)-microglobulin KO B6 donor mice engrafted into RAG(-/-) hosts were Th2 and MHC-II restricted. These data indicate that MHC-II-dependent as well as MHC-II-independent CD4(+) T cells can induce a severe and lethal IBD in congenic, immunodeficient hosts, but that the former need the latter to express its IBD-inducing potential.
Exploring peer-to-peer infrastructure for Computer Supported Collaborative Work applications (2015)

Computer Supported Collaborative Work (CSCW) has been greatly enhanced by technology that provides almost real-time capture, replay, and sharing of content. “The cloud” has popularized ease of deployment for apps serviced through a centralized approach. In this work we propose a more aggressive design, decentralizing the location of shared content within a peer-to-peer structure. Ease of deployment is maintained through a novel architecture for a multilayer distributed cloud. This paper describes how this approach has shown promise in a prototype app, ThinkTogether, and the potential to enable a consistent user experience, even for remote peers sharing VoIP.
Surface Profiling by Analysis of White-light Interferograms in the Spatial Frequency Domain (1995)

Abstract We describe a scanning white-light interferometer for high-precision surface structure analysis. Interferograms for each of the image points in the field of view of the instrument are generated simultaneously by scanning the object in a direction perpendicular to the object surface, while recording detector data in digital memory. These interferograms are then transformed into the spatial frequency domain and the surface height for each point is obtained by examination of the complex phase as a function of frequency. The final step is the creation of a complete three-dimensional image constructed from the height data and corresponding image plane coordinates. The measurement repeatability is better than 0·5 nm r.m.s. for a surface height range of 100 μm.
Prevention of seasonal influenza outbreak via healthcare insurance (2022)

The outbreak of seasonal flu costs billions of dollars in health care utilization and lost productivity. Despite the effectiveness of vaccination and antiviral medications to prevent serious flu-related complications and slow down the spread of an influenza epidemic, only 52% of the U.S. population aged 6 months and older received flu vaccines in the 2019-20 flu season. In addition, a costly out-of-pocket expense results in fewer patients seeking treatment, leading to potential hospitalizations and even flu-related deaths. In this study, we develop an integrated healthcare insurance mechanism that optimizes two incentive policies, vaccination reward and cost-sharing, to alleviate the medical cost and disease burden while preventing the outbreak of seasonal influenza. We model the dynamic interaction between a single insurer and multiple insureds as a Stackelberg vaccination game; we then embed the game into an agent-based simulation to model the spread of flu in a population under different policies. Finally, we apply machine learning and simulation optimization to optimize healthcare incentive policies in a large-scale flu transmission simulation. Simulation results indicate that the proposed methodology efficiently identifies a set of good incentive policies under different scenarios of flu vaccine efficacy and reproduction numbers.
ChemInform Abstract: POLYAMINE BIOSYNTHESIS IN RAT PROSTATE. SUBSTRATE AND INHIBITOR PROPERTIES OF 7‐DEAZA ANALOGS OF DECARBOXYLATED S‐ADENOSYLMETHIONINE AND 5′‐METHYLTHIOADENOSINE (1977)

Abstract Durch Substitution erhält man aus den beiden Adenosin‐Derivaten (Ia) und (Ib) die Substitutionsprodukte (II)‐(V).
Substantially Improving Device Performance of All‐Inorganic Perovskite‐Based Phototransistors via Indium Tin Oxide Nanowire Incorporation (2020)

All-inorganic halide perovskites (IHPs) have attracted enormous attention due to their intrinsically high optical absorption coefficient and superior ambient stabilities. However, the photosensitivity of IHP-based photodetectors is still restricted by their poor conductivities. Here, a facile design of hybrid phototransistors based on the CsPbBr<sub>3</sub> thin film and indium tin oxide (ITO) nanowires (NWs) integrated into a InGaZnO channel in order to achieve both high photoresponsivity and fast response is reported. The metallic ITO NWs are employed as electron pumps and expressways to efficiently extract photocarriers from CsPbBr<sub>3</sub> and inject electrons into InGaZnO. The obtained device exhibits the outstanding responsivity of 4.9 × 10<sup>6</sup> A W<sup>-1</sup> , which is about 100-fold better than the previous best results of CsPbBr<sub>3</sub> -based photodetectors, together with the fast response (0.45/0.55 s), long-term stability (200 h in ambient), and excellent mechanical flexibility. By operating the phototransistor in the depletion regime, an ultrahigh specific detectivity up to 7.6 × 10<sup>13</sup> Jones is achieved. More importantly, the optimized spin-coating manufacturing process is highly beneficial for achieving uniform InGaZnO-ITO/perovskite hybrid films for high-performance flexible detector arrays. All these results can not only indicate the potential of these hybrid phototransistors but also provide a valuable insight into the design of hybrid material systems for high-performance photodetection.
Advances in the Study of Heart Development and Disease Using Zebrafish (2016)

Animal models of cardiovascular disease are key players in the translational medicine pipeline used to define the conserved genetic and molecular basis of disease. Congenital heart diseases (CHDs) are the most common type of human birth defect and feature structural abnormalities that arise during cardiac development and maturation. The zebrafish, <i>Danio rerio</i>, is a valuable vertebrate model organism, offering advantages over traditional mammalian models. These advantages include the rapid, stereotyped and external development of transparent embryos produced in large numbers from inexpensively housed adults, vast capacity for genetic manipulation, and amenability to high-throughput screening. With the help of modern genetics and a sequenced genome, zebrafish have led to insights in cardiovascular diseases ranging from CHDs to arrhythmia and cardiomyopathy. Here, we discuss the utility of zebrafish as a model system and summarize zebrafish cardiac morphogenesis with emphasis on parallels to human heart diseases. Additionally, we discuss the specific tools and experimental platforms utilized in the zebrafish model including forward screens, functional characterization of candidate genes, and high throughput applications.
Surface Tension and Fluid Flow Driven Self-Assembly of Ordered ZnO Nanorod Films for High-Performance Field Effect Transistors (2006)

Colloidal nanorods of inorganic semiconductors are of interest for a range of optoelectronic devices. The ability to self-assemble these materials into ordered arrays by solution-processing techniques is crucial for achieving adequate device performance. Here we show that uniform ZnO nanorod films with defined nanorod alignment can be solution-deposited over large areas by controlling the surface energy of the nanorods through the choice of suitable ligands and by the fluid flow direction during growth. ZnO nanorods with long carbon chain ligands exhibit a smaller surface free energy than those with short carbon chain ligands resulting in better in-plane alignment and large domain sizes up to dozens of micrometers in spin-coated films. A model is presented to rationalize the observed self-assembly behavior. It is based on the formation of a lyotropic liquid crystalline phase on the surface of the liquid film which is facilitated by enhanced segregation of nanorods with low surface tension to the surface. Alignment of the nanorods is controlled by radial and vertical liquid flows in the drying solution. The ability to control the orientation of the nanorods and to achieve large domain size results in significant device performance improvement. Field-effect transistors with mobilities of up to 1.2-1.4 cm2/V.s are demonstrated in spin-coated, in-plane aligned ZnO nanorod films subject to postdeposition hydrothermal growth.
Photoionization cross section of1sorthoexcitons in cuprous oxide (2014)

We report measurements of the attenuation of a beam of orthoexciton polaritons by a photoionizing optical probe. Excitons were prepared in a narrow resonance by two photon absorption of a 1.016 eV, 54 ps pulsed light source in cuprous oxide (${\mathrm{Cu}}_{2}\mathrm{O}$) at 1.4 K. A collinear, 1.165 eV, 54 ps probe delayed by 119 ps was used to measure the photoionization cross section of the excitons. Two photon absorption is quadratic with respect to the intensity of the pump and leads to polariton formation. Ionization is linear with respect to the intensity of the probe. Subsequent carrier recombination is quadratic with respect to the intensity of the probe, and is distinguished because it shifts the exciton momentum away from the polariton anticrossing; the photoionizing probe leads to a rise in phonon-linked luminescence in addition to the attenuation of polaritons. The evolution of the exciton density was determined by variably delaying the probe pulse. Using the probe irradiance and the reduction in the transmitted polariton light, a cross section of $(3.9\ifmmode\pm\else\textpm\fi{}0.2)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}22}$ ${\mathrm{m}}^{2}$ was deduced for the probe frequency.
Current Density Variations Under Land and Channel in DMFCs (2014)

Separate measurement of current density under the different regions of the flow field geometry, i.e. under the land and under the channel, in DMFCs is significant. Such measurements may reveal the mechanisms and the effects of the various coupled parameters that influence the cell performance. Moreover, it can provide guidance for flow field design optimizations and could eventually lead to practical solutions to mitigate methanol crossover and/or its effects. A novel technique is used to directly measure the current density under the land and under the channel separately. In this method, the anode side of the cell is partially catalyzed depending on the area of interest (land, channel or full), whereas the cathode side is always fully catalyzed. The experimental results show that the current density under the land is significantly higher than that under the channel. The drastic difference in performance is attributed to the much higher electrochemical active area (ECA) under the land as shown by CO stripping voltammetry measurements.
Phase II Study of Dasatinib in Patients with Relapsed CLL (2008)

Abstract Preclinical studies have demonstrated that the Src-related tyrosine kinase Lyn is upregulated and constitutively activated in CLL cells. Lyn inhibitors have been shown to reduce survival of CLL cells in vitro and the Src inhibitor PPW results in the death of murine B cell leukemia. This has spurred interest in the role of Src inhibition as a treatment option for patients with CLL. Dasatinib is a dual Src- and Abl-kinase inhibitor that was recently approved by the FDA for the treatment of patients with CML failing imatinib. It has been shown to induce apoptosis in CLL cells in vitro. The aim of this study was to investigate the activity of dasatinib in patients with relapsed CLL. Patients with relapsed CLL, SLL, T-PLL and normal organ function were eligible. The dose of dasatinib was 50 mg PO bid continuously with possible escalation up to 70 mg bid. Each cycle was 4 weeks. Thirteen patients have been treated. The median age was 67 years (range, 42 to 83). The median number of prior treatments was 4 (range, 1 to 8). Five patients (38%) had Rai stage 0–1 disease, the other 8 (62%) had stage II–IV disease. Two patients were inevaluable for response; one changed his mind after only 2 days of treatment and the other patient was hospitalized with Aspergillus 2 weeks into treatment. Of the remaining 11 patients, 6 were treated for 3 cycles, 1 for 6 cycles, 1 is still on treatment, and 3 had therapy stopped after 2, 15, and 34 days for lip numbness, persistent headache, and thrombocytopenia/fatigue, respectively. Five patients had dose escalation after cycle 1, and 1 patient had escalation after cycle 3. The Grade 1 and 2 toxicities included 38% headache, 38% flushing, 46% fatigue, 46% anorexia/nausea, and 23% diarrhea. One patient (8%) had both Grade 3–4 headache and fatigue. One patient (8%) had Grade 3–4 diarrhea and another (8%) had a Grade 3 pleural effusion. Hematologic toxicities included neutropenia in 76%, (grade 3-4 63%), thrombocytopenia in 44% (grade 3–4 22%), and 80% with Grade 1–2 anemia. Eleven patients were evaluable for response. No patient achieved CR or PR based on NCI-WG Criteria. Several patients showed evidence of biologic activity of dasatinib including 1 PR in nodes but worsening anemia, 1 stable disease for 3 cycles, and 2 patients with significant reductions in ALC; one patient had a drop from 76,000/ml to 32,000/ml after only 2 days of dasatinib but stopped therapy because of headache, one had a reduction in WBC from 40,000 to 6,000. One patient continues on therapy. In this trial dasatinib produced no responses by NGI-WG criteria but showed evidence of biologic activity in a very heavily pretreated group of pts with CLL. Accrual continues.