gebhart/patrepeval huggingface dataset:
Bis(arylamino)tetrachlorophosphonitriles and Bis(arylamino) tetrakis(polyfluoroalkoxy)phosphonitriles (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBis(arylamino)tetrachlorophosphonitriles and Bis(arylamino) tetrakis(polyfluoroalkoxy)phosphonitrilesHenry Lederle, Gerhard Ottmann, and Ehrenfried KoberCite this: Inorg. Chem. 1966, 5, 10, 1818–1820Publication Date (Print):October 1, 1966Publication History Published online1 May 2002Published inissue 1 October 1966https://pubs.acs.org/doi/10.1021/ic50044a040https://doi.org/10.1021/ic50044a040research-articleACS PublicationsRequest reuse permissionsArticle Views36Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nonpalpable Breast Cancer in Women Aged 40-49 Years: A Surgeon's View of Benefits From Screening Mammography (1997)

While mammography screening among women aged 50 years or older has proven to reduce breast cancer mortality, screening in younger women has been repeatedly scrutinized. To test the effect of screening among younger women, we examined 84 consecutive patients aged 40-49 at the time of breast cancer diagnosis: 27 (32.1%) were diagnosed solely by mammography, and 57 (67.9%) had a palpable mass. The mean tumor sizes were 1.3 cm and 3.6 cm for the two groups respectively. While 68.8% nonpalpable invasive tumors were classified as Stage I cancer, only 34% of patients with palpable breast cancer had Stage I disease. None of the patients with nonpalpable breast cancer had disease beyond Stage II. In contrast, 28.3% of the patients with palpable invasive breast cancer presented with advanced disease. In addition, 6.3% versus 41.5% of patients with nonpalpable and palpable breast cancer respectively had nodal metastases. The five-year survival rates for the two groups were 100% and 73% respectively, favoring breast cancer detected mammographically. Screening of women aged 40-49 also resulted in more breast-conserving surgery and less chemotherapy. We conclude that screening in this age group should be continued, although individual assessment is needed.
HLA Antigens and Susceptibility to Psoriasis Vulgaris in a Non‐Caucasian Population (1976)

Fifty-four unrelated Japanese patients with psoriasis vulgaris were tissue typed using the Sixth International Histocompatibility Workshop antisera. Two control groups were included in this study: Thirty-one pustulosis palmaris et plantaris and 17 seborrheic dermatitis as a disease control and 66 normal, healthy, unrelated Japanses as a reference. HLA-Al (P = 0.0065) from the A locus and HLA-BW37 (P = 0.0164) from the B locus were found to occur with increased frequency in patients with psoriasis vulgaris. No significant difference in antigen frequencies in pustulosis palmaris et plantaris was found, however, HLA-AW30 and/or AW31 and HLA-B12 occurred with increased frequency in seborrheic dermatitis. No linkage between psoriasis and HLA was observed in eight families. Therefore our findings in Japanese do not confirm the previous observation made in Caucasians of an association between psoriasis vulgaris and HLA-B13 or BW17.
Perspectives on Development of a Combination Pharmacogenomic Diagnostic and Drug Product (2006)

This perspective outlines the challenges to joint development of a predictive genetic diagnostic with a drug to enhance the efficacy or safety of therapy with the targeted drug. Joint development requires a discovery approach to identify the genetic marker(s), followed by a replication or validation process confirming the clinical utility of the genetic marker(s) in predicting response to the targeted drug. The promise of overcoming these hurdles is that combined use of the genetic diagnostic linked to the drug provides additional scientific information to assist the clinician in their choice of therapeutic interventions on a patient-by-patient basis.
Technical descriptions of four hemispherectomy approaches: From the Pediatric Epilepsy Surgery Meeting at Gothenburg 2014 (2017)

Hemispherectomy is a complex multistep procedure with a steep learning curve. Several surgical approaches have been developed, but each requires considerable practice to master. Four experienced pediatric neurosurgeons, who participated in the 2014 Gothenburg Pediatric Epilepsy Surgery Meeting, provided succinct technical summaries of four hemispherectomy approaches: modified functional hemispherectomy, peri-insular hemispherotomy, parasagittal hemispherotomy, and endoscopic-assisted hemispherotomy. No clinical or outcome data are included. Our intention is to reduce the slope and length of the learning curve for surgeons and to improve the understanding of the technical details of hemispherectomy surgery by nonsurgeonmembers of epilepsy teams.
중국의 환경정책과 황사 발생 저감을 위한 동북아 환경협력 (2003)

황사문제의 경우, 중국 자국 내의 문제에서 그치는 것이 아니라 국제적인 차원의 규모로 확대 될 가능성이 매우 크다는 점에서 합리적인 자료의 추정 및 분석 등이 매우 필요한 문제라고 볼 수 있다. 따라서 이러한 점을 고려하여 본 연구에서는 황사로 인한 오염 현황과 발생원인을 중점적으로 분석하고, 중국의 환경농업 정책의 특성과 한계점을 제시하여 그에 따른 황사문제의 심각성과 경제적, 사회적 피해비용 추정에 대한 분석을 함께 제시함을 통해 문제의 궁극적이고 근본적인 해결을 위한 동북아 환경협력의 방안을 제시하고자 하는데 목적을 두고있다.
Allogeneic peripheral blood progenitor cell (PBPC) transplantation in children with haematological malignancies (1997)

We report on five children with haematological malignancies who underwent allogeneic peripheral blood progenitor cell (PBPC) transplantation. PBPC were harvested from HLA-identical sibling donors after G-CSF (10 micrograms/kg/d s.c.) mobilization. Aphereses were carried out on day 5 after G-CSF using a Cobe Spectra blood cell separator. All PBPC allografts were cryopreserved before transplantation. The median of CD34+ cells and CD3+ cells infused were 14.1 x 10(6)/kg recipient body weight (range 4.92-22.3) and 2.40 x 10(8)/kg recipient body weight (range 0.54 4.82), respectively. Engraftment occurred in all cases. The median time to a neutrophil count > 0.5 x 10(9)/l and a platelet count > 20 x 10(9)/l were 15 and 14 d, respectively. The incidence of severe acute graft-versus-host disease was 20%. These data suggest that allogeneic PBPC transplantation might be an alternative to bone marrow transplantation in children.
Multi-scale Aggregation R-CNN for 2D Multi-person Pose Estimation (2019)

Multi-person pose estimation from a 2D image is challenging because it requires not only keypoint localization but also human detection. In state-of-the-art top-down methods, multi-scale information is a crucial factor for the accurate pose estimation because it contains both of local information around the keypoints and global information of the entire person. Although multi-scale information allows these methods to achieve the state-of-the-art performance, the top-down methods still require a huge amount of computation because they need to use an additional human detector to feed the cropped human image to their pose estimation model. To effectively utilize multi-scale information with the smaller computation, we propose a multi-scale aggregation R-CNN (MSA R-CNN). It consists of multi-scale RoIAlign block (MS-RoIAlign) and multi-scale keypoint head network (MS-KpsNet) which are designed to effectively utilize multi-scale information. Also, in contrast to previous top-down methods, the MSA R-CNN performs human detection and keypoint localization in a single model, which results in reduced computation. The proposed model achieved the best performance among single model-based methods and its results are comparable to those of separated model-based methods with a smaller amount of computation on the publicly available 2D multi-person keypoint localization dataset.
Boiling Point Rise Calculations in Sodium Salt Solutions (2008)

The boiling point rise (elevation) of aqueous industrial solutions is often regarded as an important property with respect to chemical process design. This work shows an application of the Pitzer method for calculating the activity coefficients to the estimation of the boiling point rise of single-component and multicomponent electrolyte solutions. Good agreement between experimental and predicted values of the boiling point elevations of solutions of several salts (NaOH, Na2CO3, Na2SO4, NaCl, Na2S2O3, Na2S, mixed NaOH−Na2CO3, and mixed Na2CO3−Na2SO4) was obtained. A method for using the boiling point rise data to obtain ionic interaction parameters for the Pitzer method is also shown.
Acquisition of Antigen-Presenting Functions by Neutrophils Isolated from Mice with Chronic Colitis (2012)

Active episodes of the inflammatory bowel diseases are associated with the infiltration of large numbers of myeloid cells including neutrophils, monocytes, and macrophages. The objective of this study was to systematically characterize and define the different populations of myeloid cells generated in a mouse model of chronic gut inflammation. Using the T cell transfer model of chronic colitis, we found that induction of disease was associated with enhanced production of myelopoietic cytokines (IL-17 and G-CSF), increased production of neutrophils and monocytes, and infiltration of large numbers of myeloid cells into the mesenteric lymph nodes (MLNs) and colon. Detailed characterization of these myeloid cells revealed three major populations including Mac-1(+)Ly6C(high)Gr-1(low/neg) cells (monocytes), Mac-1(+)Ly6C(int)Gr-1(+) cells (neutrophils), and Mac-1(+)Ly6C(low/neg)Gr-1(low/neg) leukocytes (macrophages, dendritic cells, and eosinophils). In addition, we observed enhanced surface expression of MHC class II and CD86 on neutrophils isolated from the inflamed colon when compared with neutrophils obtained from the blood, the MLNs, and the spleen of colitic mice. Furthermore, we found that colonic neutrophils had acquired APC function that enabled these granulocytes to induce proliferation of OVA-specific CD4(+) T cells in an Ag- and MHC class II-dependent manner. Finally, we observed a synergistic increase in proinflammatory cytokine and chemokine production following coculture of T cells with neutrophils in vitro. Taken together, our data suggest that extravasated neutrophils acquire APC function within the inflamed bowel where they may perpetuate chronic gut inflammation by inducing T cell activation and proliferation as well as by enhancing production of proinflammatory mediators.
Tip surface silicidation to improve emission behavior of field emitter arrays (2002)

In this study, various metal silicides including Ti and Co were applied to gated poly-Si field emitter arrays, and their emission properties have been compared. Silicides were produced by deposition of 25-nm-thick metals on emitter tips through the gate opening and subsequent rapid thermal annealing under N/sub 2/ environment with flow rate of 7.5 slpm. XRD measurement was done to look the constituent and dominant binds of metal-Si compounds. It was found that all the metal layers were completely transformed into MSi/sub 2/ (M: metal element).
Preoperative planning and intraoperative guidance for accurate computer-assisted minimally invasive hip resurfacing surgery (2006)

Hip resurfacing is an alternative to total hip replacement (THR) and is particularly suitable for the younger, more active patient. However, it is a more demanding procedure. This paper describes a system that enables the surgeon to plan the surgery preoperatively with optimally sized and placed components, and then transfer this plan to an intraoperative system that registers computer models to the real patient and tracks surgical tools, allowing the surgeon to ensure that the bone is resected correctly and that the components are fitted in accordance with the plan. The paper describes a series of instruments used with the system which are locked to the bone. These instruments serve the dual purpose of soft tissue retraction and bone immobilization. The system will shortly be the subject of laboratory and clinical evaluation. Registration, a cornerstone of the tracked instrument system, has been tested, and accuracy measures are provided. Experimental results for the remainder of the system will be provided after clinical trials.
Supraglottic Atomization of Surfactant in Spontaneously Breathing Lambs Receiving Continuous Positive Airway Pressure (2017)

In our model of spontaneously breathing lambs receiving CPAP, supraglottic atomization of Curosurf via a novel device was safe, improved oxygenation and ventilation homogeneity compared with CPAP only, and provided a relatively large lung deposition suggesting clinical utility.
Design of Experiments for Capillary Electrophoretic Enantioresolution of Tamsulosin using Sulfated‐β‐Cyclodextrin as Chiral Selector (2006)

Abstract A method of quickly determining tamsulosin enantiomers by capillary zone electrophoresis with a photodiode array detector was developed. Response surface methodologies based on three‐level, three‐variable designs such as Box‐Behnken design, central composite face‐centered, and central composite circumscribed design, were comparatively used for the optimization with respect to selector concentration, applied voltage, and column temperature. Statistical interpretation of the variables on different responses, such as resolution and migration time of the last isomer were performed. The optimum conditions of these variables were predicted by using a second‐order polynomial model, fitted to the results obtained by applying three designs. The response surface plots using three experimental designs revealed a separation optimum with 100 mM tris (hydroxymethyl) aminomethane buffered with phosphoric acid to pH=2.5, concentration of sulfated‐β‐cyclodextrin, 0.15% (W/V), column temperature 25°C, and applied voltage of 25 kV. The significance of the statistical designs was confirmed by the generally good agreement obtained between predicted responses and actual experimental data. We have concluded that experimental designs offer a rapid means of optimizing several variables, and provide an efficient test for the robustness of the analytical method.
Platelet-associated CD40/CD154 mediates remote tissue damage after mesenteric ischemia/reperfusion injury (54.1) (2012)

Abstract Several innate and adaptive immune cell types participate in ischemia/reperfusion induced tissue injury. Amongst them, platelets have received little attention as contributors in the process of tissue damage after ischemia reperfusion (I/R) injury. It is currently unknown whether platelets participate through the immunologically important molecules including, CD40 and when activated, CD154 (CD40L), in the pathogenesis of I/R injury. We hypothesized that constitutive expression of CD40 and activation-induced expression of CD154 on platelets mediate local mesenteric and remote lung tissue damage after I/R injury. Wild type (WT; C57BL/6J), CD40 and CD154 deficient mice underwent mesenteric ischemia for 30 minutes followed by reperfusion for 3 hours. WT mice subjected to mesenteric I/R injury displayed both local intestinal and remote lung damage. In contrast, there was significantly less intestinal damage and no remote lung injury in CD40 and CD154 deficient mice when compared to WT mice. Platelet-depleted WT mice transfused with platelets from CD40 or CD154 deficient mice failed to reconstitute remote lung damage. In contrast, when CD40 or CD154 deficient mice were transfused with WT platelets lung tissue damage was re-established. Together, these findings suggest that multiple mechanisms are involved in local and remote tissue injury and also identify platelet-expressed CD40 and/or CD154 as mediators of remote tissue damage.
Crawl positioning improves set-up precision and patient comfort in prone whole breast irradiation (2020)

Prone positioning for whole-breast irradiation (WBI) reduces dose to organs at risk, but reduces set-up speed, precision, and comfort. We aimed to improve these problems by placing patients in prone crawl position on a newly developed crawl couch (CrC). A group of 10 right-sided breast cancer patients requiring WBI were randomized in this cross-over trial, comparing the CrC to a standard prone breastboard (BB). Laterolateral (LL), craniocaudal (CC) and anterioposterior (AP) set-up errors were evaluated with cone beam CT. Comfort, preference and set-up time (SUT) were assessed. Forty left and right-sided breast cancer patients served as a validation group. For BB versus CrC, AP, LL and CC mean patient shifts were - 0.8 ± 2.8, 0.2 ± 11.7 and - 0.6 ± 4.4 versus - 0.2 ± 3.3, - 0.8 ± 2.5 and - 1.9 ± 5.7 mm. LL shift spread was reduced significantly. Nine out of 10 patients preferred the CrC. SUT did not differ significantly. The validation group had mean patient shifts of 1.7 ± 2.9 (AP), 0.2 ± 3.6 (LL) and - 0.2 ± 3.3 (CC) mm. Mean SUT in the validation group was 1 min longer (P < 0.05) than the comparative group. Median SUT was 3 min in all groups. The CrC improved precision and comfort compared to BB. Set-up errors compare favourably to other prone-WBI trials and rival supine positioning.
Eliciting honest value information in a batch-queue environment (2007)

Markets and auctions have been proposed as mechanisms lor efficiently and fairly allocating resources in a number of different computational settings. Economic approaches to resource allocation in batch-controlled systems, however, have proved difficult due to the fact that, unlike reservation systems, every resource allocation decision made by the scheduler affects the turnaround time of all jobs in the queue. Economists refer to this characteristic as an "externality", where a transaction affects more than just the immediate resource consumer and producer. The problem is particularly acute for computational grid systems where organizations wish to engage in service-level agreements but are not at liberty to abandon completely the use of space-sharing and batch scheduling as the local control policies. Grid administrators desire the ability to make these agreements based on anticipated user demand, but eliciting truthful reportage of job importance and priority has proved difficult due to the externalities present when resources are batch controlled. In this paper we propose and evaluate the application of the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Expected Externality Mechanism</i> as an approach to solving this problem that is based on economic principles. In particular, this mechanism provides incentives for users to reveal information honestly about job importance and priority in an environment where batch-scheduler resource allocation decisions introduce "externalities" that affect all users. Our tests indicate that the mechanism meets its theoretical predictions in practice and can be implemented in a computationally tractable manner.
On the structure of delegation networks (2002)

In new distributed key-oriented access control systems such as SPKI, access rights are delegated by a freely formed network of certificates. The author formalizes the concept of a delegation network and presents a formal semantics for the delegation of access rights with certificates. The certificates can have multiple subjects who must co-operate to use the authority. Some fundamental properties of the system are proven, alternative techniques for authorization decisions are compared and their equivalence is shown rigorously. In particular he proves that certificate reduction is a sound and complete decision technique. He also suggests a new type of threshold certificate and proves its properties.
Scattering theory of the Josephson effect in iron based superconductors (2014)

We study the Josephson effect in S±IS± junctions made by a two band superconductor with s± wave symmetry. We derive the Andreev coefficients for the scattering problem at the junction interface and the temperature dependence of the critical current. We predict various features of the Josephson current for certain values of the second band strengths and tunnel barrier amplitude among which a high temperature π state coupling, and a π to 0 transition as the temperature lowers.
Constitutive uncoupling of pathways of gene expression that control growth and differentiation in myeloid leukemia: a model for the origin and progression of malignancy. (1980)

Chemical carcinogens and tumor promoters have pleiotropic effects. Tumor initiators can produce a variety of mutations and tumor promotres can regulate a variety of physiological molecles that control growth and differentiation. The appropriate mutation and the regulation of the appropriate molecules to induce cell growth can initiate and promote the sequence of changes required for transformation of normal cells into malignant cells. After this sequence of changes, some tumors can still be induced to revert with a high frequency from a malignant phenotype to a nonmalignant phenotype. Results obtained from analysis of regulation of growth and differentiation in normal and leukemic myeloid cells, the phenotypic reversion of malignancy by induction of normal differentiation in myeloid leukemia, and the blocks in differentiation-defective leukemic cell mutants have been used to propose a general model for the origin and progression of malignancy. The model states that malignancy originates by changing specific pathways of gene expresion required for growth from inducible to constitutive in cells that can still be induced to differentiate normally by the physiological inducer of differentiation. The malignant cells, unlike the normal cells, then no longer require the physiological inducer for growth. This changes the requirements for growth and uncouples growth from differentiation. Constitutive expression of other specific pathways can uncouple other controls, which then causes blocks in differentiation and the further progression of malignancy. The existence of specific constitutive pathways of gene expression that uncouple controls in malignant cells can also exlain the expresion of fetal proteins, hormones, and some other specialized products of normal development in various types of tumors.
ACTIVE INCEPTORS IN FHS FOR PILOT ASSISTANCE SYSTEMS (2010)

Pilot assistance systems or their functions can help the pilot to easier perform a safe and effective 24h all weather operation by a combination of advanced visual cueing and intelligent control augmentation. This classical two dimensional optimization problem can be extended by a third dimension, namely tactile cueing. With increasing level of control augmentation for helicopters, driven by fly-by-wire technology, also their handling qualities (flying qualities) are tailored by using advanced control modes like attitude command or translational rate command. To get fully access to the overall active rotorcraft, also the pilot inceptors are considered to exhibit active features, which are the dynamic force-displacement characteristics. This allows the adaptation of these characteristics to the control law and control modes, and in addition tactile cueing or feedback in an integrated approach. This reduces the workload and increases the situational awareness. DLR has integrated two active sidesticks into its flying helicop-ter simulator FHS: one stick replaces the cyclic centrestick, the other one the collective lever and optionally the pedals.