gebhart/patrepeval huggingface dataset:
Polymer Interactions with Drugs and Excipients (2008)

Interactions between drugs and excipients with polymeric film-forming agents influence the properties, functionality, and permeability of the applied film. Interactions can take place in the solid state at the substrate and polymer film interface, during preparation of a coating solution, or during film formation and dissolution.
Y-Ba-Cu-O/AlOx/Nb Josephson Tunnel Junctions (1987)

We have fabricated Y-Ba-Cu-O/AlO x /Nb Josephson tunnel junctions using electron-beam evaporation of Al and Nb films and natural oxidation. Superconducting Josephson current, hysteresis, and rf-induced voltage steps at a voltage greater than 0.4 mV have been clearly observed at 4.2 K. Moreover, rf-induced subharmonic steps have appeared. Magnetic field dependence of the superconducting Josephson current has also been studied.
Biofilm formation by Pseudomonas fluorescens WCS365: a role for LapD (2006)

A role for the outer-membrane-associated LapA protein in early biofilm formation by Pseudomonas fluorescens WCS365 has previously been shown. This paper reports that lapD, a gene located adjacent to the lapA gene, also plays a role in biofilm formation. A mutation in lapD results in a conditional biofilm defect in a static assay - this biofilm phenotype is exacerbated when biofilm formation is assayed in a flow-cell system. Furthermore, a lapD mutation shows a partial defect in the transition from reversible to irreversible attachment, consistent with an early role for the lapD gene product in biofilm formation. LapD is shown to be localized to the inner membrane of P. fluorescens. The data show decreased LapA associated with the cell surface, but no apparent change in cytoplasmic levels of this protein or lapA transcription, in a lapD mutant. A model is proposed wherein the role of LapD in biofilm formation is modulating the secretion of the LapA adhesin.
Copeptin concentration in cord blood in infants with early-onset sepsis, chorioamnionitis and perinatal asphyxia (2011)

Copeptin concentrations were strongly related to factors associated with perinatal stress such as birth acidosis, asphyxia and vaginal delivery. In contrast, copeptin appears to be unsuitable for the diagnosis of EOS.
Phase-only pulse shaper for multi-octave light sources (2019)

Continuous spectral phase shaping is demonstrated over a spectral bandwidth spanning from 540 nm to 2500 nm (450 THz) with a modulation dynamic large enough to shape single-cycle pulses or even transient electric fields in the near infrared.
Regulation of Gene Expression and Transcription Factor Binding Activity during Cellular Aging (1996)

Human diploid fibroblasts (HDFs) undergo a limited number of population doublings in vitro and are widely used as a model of cellular aging. Despite growing evidence that cellular aging occurs as a result of altered gene expression, little is known about the activity of transcription factors that regulate gene expression in aging cells. Here we survey the relevant literature regarding altered gene expression and the role of transcription factors during cellular aging, focusing upon the serum response factor (SRF). SRF is hyperphosphorylated in senescent HDFs and fails to bind to the serum-response element in the c-fos promoter. Differential phosphorylation during replicative aging may contribute, at least in part, to the altered activity of SRF and possibly other transcription factors and to subsequent changes in the expression of serum-regulated genes in senescent HDFs.
A functional FinFET-DGCMOS SRAM cell (2003)

An operational six-transistor SRAM cell is experimentally demonstrated using Double Gate CMOS FinFET technology. A cell size of 4.8 /spl mu/m/sup 2/ was achieved in 180 nm node technology, with stable operation at 1.5 V using a single level of copper interconnect. To our knowledge this represents the first experimental demonstration of a fully integrated FinFET SRAM Cell.
Multi-DoF Force Characterization of Soft Actuators (2019)

Soft actuators provide highly adaptable actuator options for applications in wearable devices, grippers, and mobile robots due to their inherent compliance. However, this compliance causes soft actuators to have virtually infinite degrees of freedom (DoF) of motion and challenges the accurate prediction of their displacement and interaction forces. While several studies have characterized soft actuators either in blocked condition or in a specific range of motion, the testing conditions often do not match actual loading conditions, which leads to discrepancies between expected and observed mechanical behaviour. Here, we propose a novel multi-DoF experimental protocol for characterizing soft actuator interaction forces by considering three critical aspects-anchoring conditions, displacement boundary conditions, and actuation power. In order to conduct this multi-DoF characterization, we designed a novel reconfigurable robotic test platform for enforcing anchoring conditions and planar displacement boundary conditions, and measuring forces at multiple contact locations. Using this experimental protocol and setup, we dictated three loading conditions-pulling force, tip loading, and three-point bending-and analyzed the interaction forces of a soft bending actuator. Our results show that the three loading conditions produce distinct actuator behaviors. This validates the importance of loading conditions on soft actuator performance.
Method for providing communication device with radio software, involves downloading radio software through available selected radio access technology and storing downloaded software designed for technology in memory. (2003)

NOVELTY - The method involves selection a radio access technology e.g. wireless local area network (WLAN), wideband code division multiple access (WCDMA) for communication device (9) for downloading radio software from download server (1). The radio software is downloaded through the available access technology and the downloaded software designed for the technology is stored in memory. USE - For providing communication device e.g. mobile terminal such as CDMA phone, GSM phone, lap top, personal computer with modem, pager, personal digital assistant (PDA) with radio software from software download server for providing radio access technologies (RAT) e.g. WCDMA, GSM/GRPS, WLAN, IEEE 802.11a, IEEE.11b . ADVANTAGE - Downloads or upgrades software intended for one radio access technology over an available radio access technology supported by the device. The software download can be performed as a background process that does not have to be coordinated with or blocking other types of traffic including data, control traffic or wireless services. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for the following: (1) communication device; (2) system for providing communication device with radio software; and (3) computer readable medium storing program for providing communication device with radio software. DESCRIPTION OF DRAWING(S) - The figure shows the simplified block diagram of the wireless network. software download server (1) backbone network (3) wireless access networks (5,7) communication device (9)
Vaccine display on synthetic bacterial spores enhances protective efficacy against Staphylococcus aureus infection (2017)

Abstract Background Modification of bacterial spore surfaces with proteins has previously been proposed as vaccine display platforms, however, relied on viable spores. Objective In the present study we describe how synthetic spore husk-encased lipid bilayers (SSHELs) can be utilized as a display platform to present protein antigens like ovalbumin and mutant staphylococcal alpha toxin (HlaH35L) as vaccines. This platform is based on 2 self-assembling proteins SpoVM and SpoIVA from Bacillus subtilis. Methods C57BL/6 mice were immunized with SSHEL (with or without adjuvant), antigen or antigen covalently bound to SSHEL (SSHEL_antigen) thrice intramuscularly at two-week intervals and serum antibody titers against SpoIVA or antigens were determined 7 days after each immunization. In select experiments mice were challenged intravenously with a lethal dose of S. aureus USA300 2 weeks after last vaccination. Untreated mice served as controls. Results Immunization of mice with SSHEL induced a similar antibody response towards SpoIVA as SSHEL that was adjuvanted in CpG or MPL-A suggesting adjuvant properties of this synthetic lipid-bilayer construct. Post vaccination serum of mice immunized with ovalbumin covalently bound to SSHEL (SSHEL_OVA) or HlaH35L covalently bound to SSHEL (SSHEL_HlaH35L) contained SpoIVA specific as well as antigen-specific (OVA or HlaH35L) antibodies. Infection of mice with a lethal dose of USA300 resulted in 100% survival of mice immunized with SSHEL_HlaH35L compared to 20% survival of non-immunized mice (P=0.01), and 40% survival of mice immunized with HlaH35L (P=0.049). In progress In ongoing studies we are evaluating the mechanism of action of SSHEL_HlaH35L that lead to protection during infection.
Grid Adaptive Sparse Bayesian Learning for 2D-DOA Estimation with L-shape Array (2019)

Sparsity based methods have gained its popularity in two-dimensional (2D) direction-of-arrival (DOA) estimation in recent years. However, these methods suffer from the off-grid problem, and also need additional angle pairing process, which results in degraded performance when applied in practice. In this paper, to address these problems, a novel and effective method named grid adaptive sparse Bayesian learning (GASBL) is proposed for 2D-DOA estimation with L-shape array from the perspective of sparse Bayesian learning. Specifically, an off-grid DOA model is proposed to enable grid adaptive refinement, and the auxiliary compound electric angle (CEA) is introduced to achieve automatic angle pairing of the elevation angles and azimuth angles. Then, a hierarchical probability framework with Laplacian prior is imposed. Finally, the 2D-DOA estimation problem is solved by Bayesian inferences. Compared with the state-of-the-art approaches, numerical results highlight the proposed method with more superior performance in terms of high angle resolution and robustness against the noise.
Family Changes Over the Long Term: A Sociological Commentary (2003)

Family structures and family law have been moving in the same direction all over the world over the past two centuries. Although general agreement exists that these changes have something to do with industrialization and with the ensuing transformation of the material basis of individual subsistence, it is nearly impossible to disentangle cause and effect in this process of the simultaneous revolution of economic and family structures. The transition from a society in which status and the family constitute the basis of social security to a society in which survival and success are based on merit has led to a disintegration of the family. But a society cannot go on functioning well unless it protects its inept, and hence the disintegration of the family is a threat to social cohesion itself.
The Effect of Hydrogen Donor Additive on the Viscosity of Heavy Oil during Steam Stimulation (2002)

The effect of the hydrogen donor additive on the viscosity of the heavy oils in the process of steam stimulation was studied. The results indicate that the heavy oil obtained from the Liaohe oilfields in China can undergo aquathermolysis at 240 °C for 24 h. After aquathermolysis, the viscosity of the oil sample decreased by 80%, and the SARA compositions changed. However, when there is no hydrogen donor additive in the reaction system, the viscosity of the reacted oil measured at different times after reaction will regress rapidly. With 0.8% tetralin, one of the most popular hydrogen donor additives, the viscosity did not regress again. The results are very useful for the popularization and application of the new technology for the in situ upgrading of heavy oil by aquathermolysis.
Photoluminescence properties of N and B codoped fluorescent 4H-SiC and 6H-SiC single crystals (2018)

In this paper, N and B codoped 4H-SiC and 6H-SiC single crystals were prepared by physical vapour transport method and their photoluminescence properties were studied. The photoluminescence spectra, dopant concentrations, Raman spectra, and transmission spectra of these obtained crystals were characterized. It is observed that the fluorescent crystals radiate a warm white light that covers a wide band spectrum from 450 nm to 750 nm when they are excited by a 325 nm laser. The doped 4H-SiC single crystal presents a higher photoluminescence intensity and larger spectral band compared to that of doped 6H-SiC single crystal under the similar growth and measurement conditions. Further analyze by doping concentration and transmission spectra indicate that the photoluminescence property is strongly influenced by the N donor and B acceptor impurity level.
Improved Solubilization of Recombinant Human Growth Hormone Inclusion Body Produced inEscherichia coli (2008)

Recombinant human growth hormone (r-hGH) overexpressed in Escherichia coli forms inactive and insoluble aggregates as inclusion bodies in the cytoplasm. The efficient solubilization of inclusion bodies is critical for cost-effective production. Contrary to a previous report, in our production system, the solubilization method by alkaline treatment including 2 M urea was ineffective. Hence various buffers containing different concentrations of urea or guanidine hydrochloride (GnHCl) at neutral and alkaline pH were attempted. Efficient solubilization (about 90%) was observed in 100 mM Tris buffer, pH 8.0, with more than 4 M GnHCl, and at pH 12.5 with more than 2 M GnHCl, but not with about 8 M of urea. The r-hGH solubilized at pH 12.5 containing 2 M GnHCl was refolded by simple dilution and purified by DEAE Sepharose anion-exchange chromatography. The biological activity of the resulting r-hGH was comparable with commercially available r-hGH in in vitro cell proliferation assay using the hGH-dependent cell line.
In Vitro Release of Endogenous Excitatory Sulfur‐Containing Amino Acids from Various Rat Brain Regions (1986)

Efflux of various amino acids from rat brain slices was determined under resting or depolarizing conditions. Slices of neocortex, hippocampus, striatum, cerebellum, mesodiencephalon, pons-medulla, and spinal cord were depolarized by K+ (50 mM) or veratrine (33 micrograms/ml). The 4-N,N-dimethylamino-azobenzene-4'-isothiocyanate (DABITC) derivatization method of Chang [Biochem. J. 199, 537-545 (1981)] for HPLC was adapted for analysis of amino acids and peptides in superfusion solutions. It allowed the separation and simultaneous detection of the sulfur-containing amino acids cysteine sulfinic acid (CSA), cysteic acid (CA), homocysteine sulfinic acid (HCSA), and homocysteic acid (HCA) at the picomole level. All four were shown to be released on depolarization in a Ca2+-dependent manner from brain slices. CSA and HCSA were released from cortex, hippocampus, mesodiencephalon, and, for HCSA only, striatum. HCA release, observed in all regions, was most prominent in cortex and hippocampus. CA was slightly increased by depolarization in hippocampus and mesodiencephalon. These sulfur-containing amino acids have been shown to exert an excitatory action on CNS neurons. The fact that these sulfur-containing amino acids are released as endogenous substances from nervous tissue supports the hypothesis that they play a role in CNS neurotransmission.
Real-time 3-D holographic imaging using photorefractive media including multiple-quantum-well devices (1998)

We discuss a real-time coherence gated three-dimensional (3-D) imaging system, based on photorefractive holography with ultrashort pulses, which has been applied to imaging through turbid media with a view to developing biomedical instrumentation. Sub-100-/spl mu/m depth-resolved images of 3-D objects embedded in a scattering medium have been obtained. Using a long integration time in rhodium-doped barium titanate (Rh:BaTiO/sub 4/), an image of a test chart has been obtained through 16 mean-free paths of scattering medium. Real-time depth-resolved imaging through 13 mean free paths of scattering medium has been demonstrated using a fast response time (<0.4 ms) photorefractive multiple quantum well device. This latter system can acquire depth-resolved images direct to video with no requirement for frame grabbing or signal processing. We discuss the tradeoffs and limitations of these photorefractive media for this application.
Theory of partial coherence as a framework for the optical modeling of Fourier transform spectrometers (1999)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. Genest and P. Tremblay, "Theory of partial coherence as a framework for the optical modeling of Fourier transform spectrometers," in Fourier Transform Spectroscopy: New Methods and Applications, OSA Technical Digest (Optica Publishing Group, 1999), paper FWE17. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Stimulated Brillouin scattering in a transverse resonator (1994)

We present an analysis of the transient buildup of light in a transverse Brillouin resonator. This predicts a reduction in the oscillation threshold for angles close to 90°. This threshold reduction is observed in an experiment that uses a frequency-doubled Q-switched Nd:YAG laser with n-hexane as the Brillouin medium. Self-pumped four-wave mixing is found to take place in the transverse resonator.
The Major Cat Allergen Fel d 1 Binds Steroid and Fatty Acid Semiochemicals: A Combined In Silico and In Vitro Study (2020)

The major cat allergen Fel d 1 is a tetrameric glycoprotein of the secretoglobin superfamily. Structural aspects and allergenic properties of this protein have been investigated, but its physiological function remains unclear. Fel d 1 is assumed to bind lipids and steroids like the mouse androgen-binding protein, which is involved in chemical communication, either as a semiochemical carrier or a semiochemical itself. This study focused on the binding activity of a recombinant model of Fel d 1 (rFel d 1) towards semiochemical analogs, i.e., fatty acids and steroids, using both in silico calculations and fluorescence measurements. In silico analyses were first adopted to model the interactions of potential ligands, which were then tested in binding assays using the fluorescent reporter N-phenyl-1-naphthylamine. Good ligands were fatty acids, such as the lauric, oleic, linoleic, and myristic fatty acids, as well as steroids like androstenone, pregnenolone, and progesterone, that were predicted by in silico molecular models to bind into the central and surface cavities of rFel d 1, respectively. The lowest dissociation constants were shown by lauric acid (2.6 µM) and androstenone (2.4 µM). The specific affinity of rFel d 1 to semiochemicals supports a function of the protein in cat's chemical communication, and highlights a putative role of secretoglobins in protein semiochemistry.
Wavelet analysis applied to removing non‐constant, varying spectroscopic background in multivariate calibration (2002)

Abstract Multiresolution, the ability to separate signals according to frequency, is one of the main advantages offered by the wavelet transform. However, the coarsening of resolution associated with this method may be problematic in some applications. The ‘wavelet prism’ (WP) method proposed here can split the signal into different frequency components, which retain the original resolution of the signal. In conjunction with a maximum information gain criterion developed here, this new method can be used to judge and remove the low‐frequency non‐constant background variation reasonably and automatically. In this paper the theory and background concerning this wavelet baseline correction method are introduced. The method is successfully applied to simulated and real near‐infrared (NIR) spectral data to deal with non‐constant background for multivariate calibration. Its performance compares favorably with the current signal correction methods for background removal. The new method appears to be an efficient method for removal of non‐constant, varying spectroscopic background, leading to a simpler and more parsimonious multivariate linear model. Copyright © 2002 John Wiley &amp; Sons, Ltd.
A high-level design and optimization tool for analog RF receiver front-ends (2002)

This paper presents a high-level analysis and optimization tool for the design of analog RF receiver front-ends, which takes all design parameters and all aspects of performance degradation (noise, distortion, self-mixing...) into account. The simulations are performed in the spectral domain with a behavioral model library for the RF building blocks. The tool allows to explore alternative RF receiver topologies as well as to investigate design trade-offs within each topology. By having integrated the performance analysis routine within a simulated annealing optimization loop, the tool can also perform an optimal high-level synthesis of a given topology towards a specific application. It then determines the optimal specifications for the RF building blocks such that the required receiver signal quality is met while the overall power and/or area consumption is minimized.
Design Of Optical Multilayer Coatings At NRCC (1986)

Programs for the design of optical multilayer systems at the NRCC are based on analysis, refinement, comprehensive search, gradual evolution and on the minus filter, flip-flop and inverse Fourier transform methods. For the purpose of this paper they have been used to design layer systems with one particular spectral transmittance curve. However, they can be applied to a wide variety of problems. Their advantages and limitations are compared and contrasted.
Differential Privacy Approach for Big Data Privacy in Healthcare (2017)

This chapter presents a survey of the most important security and privacy issues related to large-scale data sharing and mining in big data with focus on differential privacy as a promising approach for achieving privacy especially in statistical databases often used in healthcare. A case study is presented utilizing differential privacy in healthcare domain, the chapter analyzes and compares the major differentially private data release strategies and noise mechanisms such as the Laplace and the exponential mechanisms. The background section discusses several security and privacy approaches in big data including authentication and encryption protocols, and privacy preserving techniques such as k-anonymity. Next, the chapter introduces the differential privacy concepts used in the interactive and non-interactive data sharing models and the various noise mechanisms used. An instrumental case study is then presented to examine the effect of applying differential privacy in analytics. The chapter then explores the future trends and finally, provides a conclusion.
Definitions of Managed Objects for Bridges (1993)

This memo defines a portion of the Management Information Base (MIB) for use with network management protocols in TCP/IP based internets.In particular it defines objects for managing MAC bridges based on the IEEE 802.1D-1990 standard between Local Area Network (LAN) segments.Provisions are made for support of transparent bridging.Provisions are also made so that these objects apply to bridges connected by subnetworks other than LAN segments.