gebhart/patrepeval huggingface dataset:
Growth and Properties of Li2B4O7 Single Crystal for SAW Device Applications (1983)

Large Li 2 B 4 O 7 single crystals, up to 45 mm in diameter, have been successfully grown along the X- and Z-axis by Czochralski technique. Fundamental phsyical and chemical properties were determined, and basic SAW properties were studied for the various surface orientations and SAW propagation directions from theoretical and experimental points of view. It was found that there were useful substrate orientations for SAW resonators and narrow bandpass SAW filters around the rotated X-cut, Z-propagation, where SAW propagation delay time was a parabolic function of temperature and SAW coupling factor k 2 was approximately 1%. When a SAW propagates along the Z-direction on the 28° rotated X-cut substrate, the temperature coefficient of delay time (TCD) is zero at 20°C and the second order TCD is 0.27 ppm/°C 2 , k 2 is 0.8% and SAW velocity v s is 3470 m/s. The bulk wave spurious signal response level is lower by -20 dB than the SAW fundamental response level.
Measuring the Ionization of O Star Winds (2000)

We present an analysis of wind line profiles from Far Ultraviolet Spectroscopic Explorer (FUSE) spectra of two O7 supergiants in the Large and Small Magellanic Clouds (Sk -67°111 and AV 232, respectively). Model fits yield the column densities of S IV, S VI, P IV, P V, N III, and N IV, providing the first direct measurement of the ionization balance in stellar winds. The ratios of S IV/S VI and P IV/P V are consistently lower in the LMC star. IUE and Hubble Space Telescope archival spectra are also used to measure N IV and N V, but the much higher optical depth makes the N V measurements inconclusive. The velocity and optical depth distributions in the wind are qualitatively similar between the two stars, when scaled to their terminal velocities. The terminal velocities are different, with AV 232 being lower (as found previously in SMC stars and linked to lower metallicity). These are the first results from a program to investigate wind ionization and velocity structure among hot stars in local galaxies, and they demonstrate the higher accuracy in measuring column densities of less abundant ions, such as phosphorus and sulfur, observable in the FUSE range.
THE BLOOD-PRESSURE IN THE EYE AND ITS RELATION TO THE CHAMBER-PRESSURE (1918)

dealt with the blood-stream as a whole, and showed in a general way how it loses lateral pressure in travelling from the left ventricle to the right auricle. From the data thus gained we can now advantageously attack the problem of the blood-pressure in the eye.
CHILD PROTECTION LAW—CARE AND PROTECTION OF WALT: REEXAMINING THE SCOPE OF JUDICIAL AUTHORITY IN THE ENFORCEMENT OF THE REASONABLE EFFORTS REQUIREMENT (2020)

When the state removes a child from the custody of his or her parents, the delicate balance between parents’ rights and the state’s obligation to protect the child comes into play. Because termination of parental rights is irrevocable, it is often referred to as the “death penalty” of family law. Historically, parents with intellectual disabilities have been denied the opportunity to parent through eugenics and sterilization, a horrific history that finds modern articulation through the removal of children from parents based on presumptions of neglect.1 When a child protection agency removes a child from parental care, without providing the support services to remedy the stated reason for removal, the parents are denied an adequate opportunity to parent their own children and the family suffers. In 2017, the Massachusetts Supreme Judicial Court decided Care and Protection of Walt, which held that if the Department of Children and Families (DCF) breaches its statutory duty to provide support services prior to removing a child, then the juvenile judge has the equitable authority to order remedial action. This Note discusses what Walt tells us about how and when judicial authority may be exercised in care and protection cases in Massachusetts, and what impact this may have on parental rights, specifically the rights of parents with intellectual disabilities.
[A case of breast cancer with bone marrow and liver metastases responding completely to low-dose weekly paclitaxel combined with toremifene]. (2001)

A 36-year-old woman was admitted to our hospital because of general malaise in October 1999. She was diagnosed with bilateral breast cancer with bone marrow and liver metastases. Low-dose weekly paclitaxel (60 mg/body/week) combined with toremifene (120 mg/day) was started in December 1999. Myelofunction was recovered after 2 weeks of chemotherapy (CT), and the primary tumors and cervical/axillary lymphadenopathy disappeared after 4 weeks of CT. Bone marrow and liver metastases was no longer detected after 16 weeks of CT, and the case was evaluated as a complete response (CR). The same therapy has been performed for eight months and no evidence of recurrence has been observed.
Acid-catalyzed nucleophilic aromatic photosubstitution. A reconsideration of protonation in excited states of nitrobenzenes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcid-catalyzed nucleophilic aromatic photosubstitution. A reconsideration of protonation in excited states of nitrobenzenesGene G. Wubbels, Douglas P. Susens, and E. Bryan. CoughlinCite this: J. Am. Chem. Soc. 1988, 110, 8, 2538–2542Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/ja00216a028https://doi.org/10.1021/ja00216a028research-articleACS PublicationsRequest reuse permissionsArticle Views158Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
After the deluge (2007)

Since she first came to the attention of the art world nearly ten years ago, Kara Walker has become one of the most important artists of her generation. Championed by the art world for her fearless embrace of challenging subject matter, Walker has created a body of work that looks unflinchingly at racial inequality in the United States. Known for her bold images using the traditional silhouette, Walker upends the genteel, Victorian origins of the medium by graphically portraying scenes from the antebellum South to explore the politics of slavery, race, and gender. Inspired by the tragedy that beset the Gulf Coast after Hurricane Katrina, Walker has created a volume exploring the interconnectedness of the subject of the sea, race, and poverty by juxtaposing examples of her work and historical works from the 19th century. This unique and important book capitalizes on Walker's deftness at graphic and visceral storytelling, affording the reader a deeply intimate experience of the difficult themes the artist explores.
Cotylenins and Fusicoccins Stimulate Seed Germination of Striga hermonthica (Del.) Benth and Orobanche minor Smith (1998)

Several fungal metabolites were examined for their effects on germination of the root parasitic weeds witchweed, Striga hermonthica (Del.) Benth, and clover broomrape, Orobanche minor Smith. Among these metabolites cotylenins (CNs) and fusicoccins (FCs) at concentrations as low as 10-5 M induced high seed germination (>50%) of both parasites. Inhibitors of ethylene biosynthesis [2-(2-aminoethoxyvinyl)glycine (AVG)] and action [silver thiosulfate (STS)] reduced CN- and FC-induced Striga germination but not that of Orobanche. This suggests that induction of Striga germination by CNs and FCs, as is the case with the true natural stimulant “strigol”, requires both ethylene biosynthesis and action, while that of Orobanche does not. Keywords: Cotylenin; fusicoccin; Orobanche minor; seed germination; Striga hermonthica
Power MEMS and microengines (2002)

MIT is developing a MEMS-based gas turbine generator. Based on high speed rotating machinery, this 1 cm diameter by 3 mm thick SiC heat engine is designed to produce 10-20 W of electric power while consuming 10 grams/hr of H/sub 2/. Later versions may produce up to 100 W using hydrocarbon fuels. The combustor is now operating and an 80 W micro-turbine has been fabricated and is being tested. This engine can be considered the first of a new class of MEMS device, power MEMS, which are heat engines operating at power densities similar to those of the best large scale devices made today.
Bi-layer polypyrrole artificial muscle valves for drug delivery systems (2005)

A miniature controllable drug delivery device in which drug release is achieved by actuating polymeric valves is introduced. The valves made in flap configuration are bilayer structures which were fabricated as a thin gold film and an electrochemically deposited polypyrrole (PPy) layer. A drug simulate was stored in a reservoir and the drug release process was accomplished by bending the bilayer flaps with a small electrical potential bias in solution. The detailed fabrication procedures of this controllable drug delivery device are presented.
Closed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (the COOL trial): study protocol for a randomized controlled trial (2018)

ClinicalTrials.gov, NCT03163095.
Data from Milk Thistle and Prostate Cancer: Differential Effects of Pure Flavonolignans from <i>Silybum marianum</i> on Antiproliferative End Points in Human Prostate Carcinoma Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;Extracts from the seeds of milk thistle, &lt;i&gt;Silybum marianum&lt;/i&gt;, are known commonly as silibinin and silymarin and possess anticancer actions on human prostate carcinoma &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;. Seven distinct flavonolignan compounds and a flavonoid have been isolated from commercial silymarin extracts. Most notably, two pairs of diastereomers, silybin A and silybin B and isosilybin A and isosilybin B, are among these compounds. In contrast, silibinin is composed only of a 1:1 mixture of silybin A and silybin B. With these isomers now isolated in quantities sufficient for biological studies, each pure compound was assessed for antiproliferative activities against LNCaP, DU145, and PC3 human prostate carcinoma cell lines. Isosilybin B was the most consistently potent suppressor of cell growth relative to either the other pure constituents or the commercial extracts. Isosilybin A and isosilybin B were also the most effective suppressors of prostate-specific antigen secretion by androgen-dependent LNCaP cells. Silymarin and silibinin were shown for the first time to suppress the activity of the DNA topoisomerase IIα gene promoter in DU145 cells and, among the pure compounds, isosilybin B was again the most effective. These findings are significant in that isosilybin B composes no more than 5% of silymarin and is absent from silibinin. Whereas several other more abundant flavonolignans do ultimately influence the same end points at higher exposure concentrations, these findings are suggestive that extracts enriched for isosilybin B, or isosilybin B alone, might possess improved potency in prostate cancer prevention and treatment.&lt;/p&gt;&lt;/div&gt;
Genomic profiles and clinical outcomes to distinguish primary from secondary metastatic hormone-sensitive prostate cancer (mHSPC). (2020)

e17558 Background: Clinical outcomes may differ among pts with primary (de novo) mHSPC vs. secondary (relapsed) mHSPC occurring after previous local therapy. However, it is unknown what molecular features distinguish these potentially distinct presentations. Methods: A single-center retrospective study was performed using pts with mHSPC and available somatic genomic data. Clinicopathologic characteristics were collected, and pts were classified as primary mHSPC (n = 118) or secondary mHSPC (n = 104). A targeted set of genes suspected to influence disease severity and response to systemic therapy was analyzed: BRCA2, PTEN, RB1, TP53, SPOP, CDK12, combined PTEN/RB1/TP53 alterations (2 out of 3), and a composite of any homologous recombination deficiency (HRD) mutation. Hazard ratios for PFS and OS were compared between groups using the log-rank test. Differences in genomic features and baseline characteristics between groups were compared using Fischer exact and chi-squared tests. Results: Median PFS from initiation of first-line ADT was 16.0 mo and 28.9 mo for men with primary and secondary mHSPC, respectively (HR 0.59, 95% CI 0.43–0.83; P= 0.002). OS did not differ between groups (HR 0.92, 95% CI 0.56–1.52; P= 0.7) There were more men with Gleason 8-10 disease in the primary vs. secondary mHSPC groups (91% vs. 67%, P= &lt; 0.01). In terms of molecular alterations, there were more PTEN and CDK12 mutations in the primary mHSPC group ( PTEN: 27% vs 19%, CDK12: 7% vs 3%), but more BRCA2 mutations in the secondary mHSPC group (5% vs 10%, respectively). In univariate analysis, PTEN mutations (HR 1.39, P= 0.08) and combined PTEN/RB1/TP53 mutations (HR 1.46, P= 0.09) predicted worse PFS; PTEN mutations (HR 1.63, P= 0.09) and combined PTEN/RB1/TP53 mutations (HR 2.38, P= 0.01) also predicted worse OS. In multivariable models adjusting for age at first metastasis and Gleason sum, only combined PTEN/RB1/TP53 mutations were predictive of worse OS (adjusted HR 2.32, 95% CI 1.14–4.71; P= 0.02). Conclusions: Compared to secondary mHSPC, primary mHSPC pts had higher Gleason scores, more frequent PTEN and CDK12 mutations, and less frequent BRCA2 mutations. In our study, such pts demonstrated worse PFS but not OS. While the strongest negative predictor of OS was the presence of combined PTEN/RB1/TP53 mutations, other contributors such as CDK12 and BRCA2 may also partially explain differences in outcomes. Thus, primary mHSPC appears to be clinically and genomically distinct from secondary mHSPC, and may require unique treatment paradigms.
Developing a truing method of ball type wheel (2004)

Grinding Center( GG )has some flexibility which enables abrasives processing of curved free surface. In grinding of free surface, CBN ball type wheel is available due to long wheel life. Although it is necessary to do truing and dressing on the ball type wheel in grinding process of curved surface, such experience-is seldom. In this study various type of truers were tried on ball type wheels. As the result it is found that a cup type diamond truer with radius end is available to do truing on a ball type wheel. In this paper some results of truing test on ball type wheel are reported.
Dynamic reconstruction of 3D structure and 3D motion (2002)

This paper presents a computational scheme for reconstructing 3D structure, 3D motion and complete surfaces from instantaneous image motion based on multiple frames. The scheme is motivated by psychophysical observations and designed to achieve efficient, robust and flexible behavior. The scheme consists of multiple interacting stages. At the structure-from-motion stage, relative depths and 3D velocities are estimated by minimizing the error in fit to the instantaneous 2D motion measurements and the overall deviation from rigidity. This nonlinear optimization is achieved by an efficient two-stage iterative algorithm. The temporal integration stage based on Kalman filtering effectively improves the 3D structure over multiple frames. The global motion of the observer or each constituent object can be computed at a later stage by using the estimated 3D velocities. The surface reconstruction stage reconstructs complete 3D surfaces, which can further stabilize the 3D structure recovery. The scheme can account for a number of psychophysical findings that include the perceptual demonstrations explored by Ramachandran et al. (Husain et al. 1989, Lappin et al. 1980) regarding interactions between two superimposed cylinders, and the experimental results using displays of moving points with short lifetimes (28, 55).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Carbon Dioxide Postcombustion Capture: A Novel Screening Study of the Carbon Dioxide Absorption Performance of 76 Amines (2009)

The significant and rapid reduction of greenhouse gas emissions is recognized as necessary to mitigate the potential climate effects from global warming. The postcombustion capture (PCC) and storage of carbon dioxide (CO2) produced from the use of fossil fuels for electricity generation is a key technology needed to achieve these reductions. The most mature technology for CO2 capture is reversible chemical absorption into an aqueous amine solution. In this study the results from measurements of the CO2 absorption capacity of aqueous amine solutions for 76 different amines are presented. Measurements were made using both a novel isothermal gravimetric analysis (IGA) method and a traditional absorption apparatus. Seven amines, consisting of one primary, three secondary, and three tertiary amines, were identified as exhibiting outstanding absorption capacities. Most have a number of structural features in common including steric hindrance and hydroxyl functionality 2 or 3 carbons from the nitrogen. Initial CO2 absorption rate data from the IGA measurements was also used to indicate relative absorption rates. Most of the outstanding performers in terms of capacity also showed initial absorption rates comparable to the industry standard monoethanolamine (MEA). This indicates, in terms of both absorption capacity and kinetics, that they are promising candidates for further investigation.
Comparison of CT-based lobar ventilation models with helium-3 MRI ventilation measurements in asthmatics (2014)

Rationale: CT models of ventilation can be computed from expiratory and inspiratory scans and the relative lung expansion at a lobar level can be used as a surrogate for ventilation. This ventilation model has previously been validated against SPECT [1]. Here we compare models of regional percentage lobar ventilation from CT with 3He MRI measurements of ventilation using multi-modality image registration in a population of 29 asthma patients.\nMethods: 29 patients with moderate-to-severe asthma underwent breath-hold CT at TLC and FRC and 3He MRI at FRC+1 liter. In the same breath, 1H MRI was acquired [2]. CT was used to segment the lobes by identification of major fissures in both lungs. These lobar masks were used to calculate percentage regional ventilation per lobe using the inspiration and expiration CT data [1]. 1H MRI was registered to inspiration CT via a diffeomorphic transform using ANTs [3]. As 1H and 3He MRI were acquired in the same breath, the transformation from 1H MRI to CT registration was applied directly to 3He MRI allowing direct comparison of lobar ventilation from CT and 3He. \nFigure. Scatter plot of 3He MRI and CT lobar ventilation measurements.\nResults: 3He MRI was successfully warped to inspiration CT using the transform derived from the 1H MRI and CT registration. The mean absolute difference between CT and 3He MRI ventilation across lobes was 4.8% (mean±SD for each lobe: RUL+RML=6.2±4.3%; RLL=5.1±5.4%; LUL=4.3±4.1%; LLL=4.8±3.7%). Greater ventilation was seen in upper lobes with 3He and in lower lobes with the CT model (see figure). This is confirmed by Bland-Altman analysis, 95% limits of agreement: RUL+RML (-4.5, 15.7), RLL (-16.3, 6.7), LUL (-5.5, 13.0), LLL (-12.5, 3.4).\nDiscussion: The mean absolute difference of 4.8% observed is larger than the 2.1% reported previously in a smaller cohort of mild asthmatics against SPECT [1]. The larger difference here may be due to increased asthma severity and differences in the nature of the ventilation measurements (e.g. different gases, image resolutions and registration). \nConclusion: This study compares percentage regional ventilation per lobe calculated by CT models with a more direct measure of gas ventilation with hyperpolarized 3He MRI.\nAcknowledgements: The EU FP7 AIRPROM consortium and Novartis provided funding for patient data. BT is funded by the University of Sheffield’s James Morrison Fund and Weston Park Hospital Cancer Charity.\nReferences: [1] Radiol 2010;257:854-862, [2] NMR Biomed 2011;24:130-134, [3] Neuroimage 2011;54:2033-2044
Supplementary Data - text from Acquired Resistance Mutations to ALK Inhibitors Identified by Single Circulating Tumor Cell Sequencing in <i>ALK</i>-Rearranged Non–Small-Cell Lung Cancer (2023)

&lt;p&gt;Supplementary Data - text&lt;/p&gt;
ChemInform Abstract: 1,7‐Octadiene‐Assisted Tandem Multicomponent Cross‐Enyne Metathesis (CEYM)‐Diels—Alder Reactions: A Useful Alternative to Mori′s Conditions. (2013)

Abstract The protocol relies on a relay metathesis process, in which 1,7‐octadiene acts as an in situ source of ethylene.
Fait Accompli: Suicide in a Rural Trauma Setting (2009)

The overwhelming majority (94%) of suicide deaths in our rural state were never seen by the trauma center, and only 1.1% were recidivists. Previous admissions for self-inflicted injuries or penetrating injuries were significant predictors of future suicide attempt and should trigger select interventions. Other factors that can to lead a suicidal tendency include a previous mental health history (depression), poly-substance abuse, and chronic pain history. In our small sample, suicidal tendencies could persist for a prolonged period of time.