gebhart/patrepeval huggingface dataset:
INTEGRAL ASSESSMENT OF THE BIOPSYCHOSOCIAL STATUS OF OLDER CITIZENS AND IMPLEMENTATION OF THE SYSTEMIC SUPPORT COMPONENTS (2021)

The article discusses the problems of determining the need of citizens of older age groups in complex medical, social and psychological assistance in the framework of the implementation of a personalized approach to the service provision. The concept of an integral assessment of the biopsychosocial status of older citizens has been introduced. Based on the ranking of subjects according to the degree of decrease in body functions due to ageing and the development of age-associated diseases, an algorithm for the implementation of the assessment has been proposed. The possibility of using this algorithm has been substantiated, and its features have been shown on the example of St. Petersburg as a model region, taking into account its technical, personnel and organizational potential. The requirements for the implementation of the systemic support components for the provision of comprehensive medical, social and psychological assistance to senior citizens in the process of organizational and technical support for an integrated assessment of their biopsychosocial status have been defined.
Performance Metrics for an Application-driven Selection and Optimization of Psychophysical Sampling Procedures (2018)

When estimating psychometric functions with sampling procedures, psychophysical assessments should be precise and accurate while being as efficient as possible to reduce assessment duration. The estimation performance of sampling procedures is commonly evaluated in computer simulations for single psychometric functions and reported using metrics as a function of number of trials. However, the estimation performance of a sampling procedure may vary for different psychometric functions. Therefore, the results of these type of evaluations may not be generalizable to a heterogeneous population of interest. In addition, the maximum number of trials is often imposed by time restrictions, especially in clinical applications, making trial-based metrics suboptimal. Hence, the benefit of these simulations to select and tune an ideal sampling procedure for a specific application is limited. We suggest to evaluate the estimation performance of sampling procedures in simulations covering the entire range of psychometric functions found in a population of interest, and propose a comprehensive set of performance metrics for a detailed analysis. To illustrate the information gained from these metrics in an application example, six sampling procedures were evaluated in a computer simulation based on prior knowledge on the population distribution and requirements from proprioceptive assessments. The metrics revealed limitations of the sampling procedures, such as inhomogeneous or systematically decreasing performance depending on the psychometric functions, which can inform the tuning process of a sampling procedure. More advanced metrics allowed directly comparing overall performances of different sampling procedures and select the best-suited sampling procedure for the example application. The proposed analysis metrics can be used for any sampling procedure and the estimation of any parameter of a psychometric function, independent of the shape of the psychometric function and of how such a parameter was estimated. This framework should help to accelerate the development process of psychophysical assessments.
Clinical Lessons to Be Learned from Patients Developing Chronic Myeloid Leukemia While on Immunosuppressive Therapy after Solid Organ Transplantation: Yet Another Case after Orthotopic Heart Transplantation (2014)

Chronic myeloid leukemia developing after transplantation of solid organs and concomitant immunosuppression is a rare but still significant clinical phenomenon. We here describe an additional case of a 62-year-old male patient developing CML after orthotopic heart transplantation and medication with cyclosporine A, mofetil-mycophenolate, and steroids. Initial antileukemic therapy was imatinib at a standard dose and within 15 months of therapy a complete cytogenetic response was noted. In this report we discuss the clinical implications of these rare but biologically important cases.
Variable density incoherent spatiotemporal acquisition (VISTA) for highly accelerated cardiac MRI (2014)

VISTA generates spatiotemporal sampling patterns with high levels of uniformity and incoherence, while maintaining a constant temporal resolution. Using a small pilot study, VISTA was shown to produce diagnostic quality images at acceleration rates up to 15.
A Randomized Trial of Intensive versus Standard Blood-Pressure Control (2015)

Among patients at high risk for cardiovascular events but without diabetes, targeting a systolic blood pressure of less than 120 mm Hg, as compared with less than 140 mm Hg, resulted in lower rates of fatal and nonfatal major cardiovascular events and death from any cause, although significantly higher rates of some adverse events were observed in the intensive-treatment group. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT01206062.).
Rapid Thermal Processing: Fixing Problems with the Concept of Thermal Budget (1997)

Until now, kinetic effects in rapid thermal processing have been assessed using the concept of thermal budget, with the idea that thermal budget minimization should minimize dopant diffusion and interface degradation. This work highlights shortcomings with that principle. Experiments directly comparing the rate of Si chemical vapor deposition with that of dopant diffusion show how thermal budget minimization can actually worsen diffusion problems rather than mitigate them. We present a straightforward framework for improving the results through comparison of activation energies of the desired and undesired phenomena. This framework explains all the experimental results and provides strong kinetic arguments for continued development of rapid isothermal processing and small batch fast ramp methods.
Fusion, rupture, and degeneration: the fate of in vivo-labelled PSVs in developing barley endosperm* (2014)

Cereal endosperm is a highly differentiated tissue containing specialized organelles for the accumulation of storage proteins. The endosperm of barley contains hordeins, which are ultimately deposited within protein storage vacuoles (PSVs). These organelles have been characterized predominantly by the histochemical analysis of fixed immature tissue samples. However, little is known about the fate of PSVs during barley endosperm development, and in vivo imaging has not been attempted in order to gain further insight. In this report, young seeds were followed through development to characterize the dynamic morphology of PSVs from aleurone, subaleurone, and central starchy endosperm cells. TIP3-GFP was used as a PSV membrane marker and several fluorescent tracers were used to identify membranes and monitor endomembrane organelles in real time. Whereas the spherical appearance of strongly labelled TIP3-GFP PSVs in the aleurone remained constant, those in the subaleurone and central starchy endosperm underwent substantial morphological changes. Fusion and rupture events were observed in the subaleurone, and internal membranes derived from both the tonoplast and endoplasmic reticulum were identified within these PSVs. TIP3-GFP-labelled PSVs in the starchy endosperm cells underwent a dramatic reduction in size, so that finally the protein bodies were tightly enclosed. Potential desiccation-related membrane-altering processes that may be causally linked to these dynamic endomembrane events in the barley endosperm are discussed.
Future Trends in Flexible Endoscopy (2003)

Over the past 20 years, flexible endoscopy has evolved from a primarily diagnostic endeavor to one of the most rapidly growing fields of therapeutic surgery. Multitudes of techniques and technologies have been developed to treat a wide spectrum of gastrointestinal diseases. Endoscopic suturing, radiofrequency energy delivery, mucosal resection, and thermal ablative techniques are among the most promising modalities in the field. Furthermore, the development of endoscopic transgastric surgery opens the door to a variety of novel intraluminal procedures. Though the ultimate role of these innovations is yet to be determined, the future of feasible surgical endoscopy holds great potential.
Power-Efficient Sensor Placement and Transmission Structure for Data Gathering under Distortion Constraints (2003)

We consider the joint optimization of sensor placement and transmission structure for data gathering, where a given number of nodes need to be placed in a field such that the sensed data can be reconstructed at a sink within specified distortion bounds while minimizing the energy consumed for communication. We assume that the nodes use joint entropy coding based on explicit communication between sensor nodes, and consider both maximum and average distortion bounds. The optimization is complex since it involves an interplay between the spaces of possible transmission structures given radio reachability limitations, and feasible placements satisfying distortion bounds.We address this problem by first looking at the simplified problem of optimal placement in the one-dimensional case. An analytical solution is derived for the case when there is a simple aggregation scheme, and numerical results are provided for the cases when joint entropy encoding is used. We use the insight from our 1-D analysis to extend our results to the 2-D case, and show that our algorithm for two-dimensional placement and transmission structure provides significant power benefit over a commonly used combination of uniformly random placement and shortest path trees.
No Gender Influences on Clinical Outcomes or Durability of Repair Following Carotid Angioplasty With Stenting and Carotid Endarterectomy (2008)

These results do not indicate substantial gender influences on clinical outcomes or durability of repair following CAS and CEA.
A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases (2020)

In high-grade serous ovarian cancer (HGSOC), higher densities of both B cells and the CD8 + T-cell infiltrate were associated with a better prognosis. However, the precise role of B cells in the antitumor response remains unknown. As peritoneal metastases are often responsible for relapse, our aim was to characterize the role of B cells in the antitumor immune response in HGSOC metastases. Unmatched pre and post-chemotherapy HGSOC metastases were studied. B-cell localization was assessed by immunostaining. Their cytokines and chemokines were measured by a multiplex assay, and their phenotype was assessed by flow cytometry. Further in vitro and in vivo assays highlighted the role of B cells and plasma cell IgGs in the development of cytotoxic responses and dendritic cell activation. B cells mainly infiltrated lymphoid structures in the stroma of HGSOC metastases. There was a strong B-cell memory response directed at a restricted repertoire of antigens and production of tumor-specific IgGs by plasma cells. These responses were enhanced by chemotherapy. Interestingly, transcript levels of CD20 correlated with markers of immune cytolytic responses and immune complexes with tumor-derived IgGs stimulated the expression of the costimulatory molecule CD86 on antigen-presenting cells. A positive role for B cells in the antitumor response was also supported by B-cell depletion in a syngeneic mouse model of peritoneal metastasis. Our data showed that B cells infiltrating HGSOC omental metastases support the development of an antitumor response. Clin Cancer Res; 1-13. ©2016 AACR.
Postmortem angiographic findings for arteries supplying the lumbar spine: their relationship to low-back symptoms. (1993)

We evaluated 56 postmortem lumbar aortograms to study differences between subjects with and without low-back pain in the lumbar and middle sacral arteries. Twenty-two of 25 (88%) cases with back pain history had one or more missing arteries, 20 (80%) of them had narrow arteries, and 18 (72%) had developed collaterals. The corresponding figures for 22 age-matched controls were 13 (59%), 12 (55%), and 12 (55%), and for nine young (i.e., age < or = 30 years) controls two (22%), two (22%), and two (22%). The cases had on average 2.04 entirely missing and 1.32 narrow (< or = 50% in diameter) arteries, compared with the age-matched controls who had 0.82 missing (p < 0.001 for difference from cases) and 0.59 narrow arteries (p < 0.01). We conclude that insufficient arterial blood flow may be an underlying factor for low-back symptoms. Atheromatous lesions in the abdominal aorta or congenital hypoplasia of the arteries may explain the angiographic findings.
Triazole‐Linked Oligonucleotides with Mixed‐Base Sequences: Synthesis and Hybridization Properties (2012)

Abstract A new class of backbone‐modified oligonucleotide analogs has emerged since the discovery of the Cu I ‐catalyzed [3+2] azide/alkyne cycloaddition reaction. These are oligonucleotide analogs with 1,4‐disubstituted 1,2,3‐triazoles as the internucleotide linkages. Of all such analogs known, only the triazole‐linked deoxythymidine decamer [(dT) 10 ] has been reported to show enhanced binding affinity to complementary DNA. Importantly, it is a fully modified (dT) 10 analog. To date, sequentially heterogeneous oligonucleotides bearing the same backbone modification have not been described. With the goal of investigating sequence and regularity dependence of the effect of this modification on duplex stability, we have designed partially modified mixed‐base oligonucleotides, which can be prepared by using a modified dinucleoside block. In this paper we report the synthesis of a dithymidine phosphoramidite analog with a triazole linker, its use in oligonucleotide synthesis and hybridization data of the resulting oligonucleotide analogs. The effect of single and multiple modifications on stability of mixed‐base duplexes is assessed and compared with published data for the oligo(T)/oligo(A) duplex. We also compared the effect of the linker concerned with that of a shorter triazole linker.
The Product Consistency Test (PCT): How and Why it Was Developed (2009)

This chapter contains sections titled: Introduction Scope of the PCT Significance and Use of the PCT The PCT and the High Level Waste (HLW) Acceptance Process Development of the PCT PCT Test Discrimination Relation of PCT Results to Other Durability Test Responses Comparison of PCT Glass Response to Other Waste Forms Conclusions
Diamond Synthesis by the Microwave Plasma CVD Method Using a Mixture of Carbon Monoxide and Hydrogen Gas (I) (1988)

Abstract The authors have succeeded in diamond synthesis by a microwave plasma chemical vapor deposition (plasma CVD) method using a mixture of CO and H2 gas, which had been thought to be difficult to achieve. The growth rate when using CO as the feedstock gas is about several times faster than that when using CH4.
Synchrony analysis of paroxysmal gamma waves in meditation EEG (2014)

Meditation is a fascinating topic that is still relatively poorly understood. To investigate its physiological traits, electroencephalograms (EEG) were recorded during meditation sessions. In a recent study, paroxysmal gamma waves (PGWs) have been discovered in EEG of meditators practicing Bhramari Pranayama (BhPr). In this paper, the synchrony between those PGWs is investigated, revealing functional connectivity patterns in the brain during BhPr. Specifically, the method “Stochastic Event Synchrony” (SES) is applied to pairs of PGW sequences in order to assess their synchrony. From those pairwise synchrony measures, large-scale functional connectivity patterns are extracted. Three subjects possessing different levels of expertise in BhPr are considered. Strong synchrony can be observed in the temporal lobes for all three subjects, in addition to long-range interhemispheric connections. Consistent connectivity patterns are present for exhalation periods of BhPr, while those patterns are substantially less stationary for inhalation periods. Interestingly, the synchrony seems to increase gradually during the meditation sessions. Moreover, the distribution of synchrony values seems to depend on the level of expertise in practicing BhPr: the higher the expertise, the more concentrated the intensity values.
Inhibition of mouse skin tumor promotion and of promoter-induced epidermal polyamine biosynthesis by methylglyoxal bis(butylamidinohydrazone) (1988)

Effects of methylglyoxal bis(butylamidinohydrazone) (MGBB), a reversible inhibitor of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases of ODC and AdoMetDC activities, ODC and mRNA level and polyamine contents in mouse skin were investigated in connection with tumor formation. Formation of papillomas by applications of TPA to 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mouse skin was effectively inhibited by simultaneous topical applications of MGBB, MGBB also dose-dependently inhibited the ability of TPA to induce increases of ODC activity, ODC mRNA level and the accumulation of putrescine and spermidine in mouse skin. Induction of AdoMetDC activity was not affected by the drug. These inhibitory effects of MGBB on ODC induction and tumor promotion were more evident in multiple application experiments than with a single application of the drug.
Airway Management in Trauma (2017)

Airway management in the trauma patient presents numerous unique challenges beyond placement of an endotracheal tube and outcomes are dependent on the provider's ability to anticipate difficulty. Airway management strategies for the care of the polytrauma patient are reviewed, with specific considerations for those presenting with traumatic brain injury, suspected c-spine injury, the contaminated airway, the agitated trauma patient, maxillofacial trauma, and the traumatized airway. An approach to airway management that considers the potential anatomic and physiologic challenges in caring for these complicated trauma patients is presented.
Diagnosing performance changes in distributed sytems by comparing requesting request flows (2013)

Diagnosing performance problems in modern datacenters and distributed systems is challenging, as the root cause could be contained in any one of the system's numerous components or, worse, could be a result of interactions among them. As distributed systems continue to increase in complexity, diagnosis tasks will only become more challenging. There is a need for a new class of diagnosis techniques capable of helping developers address problems in these distributed environments. 
As a step toward satisfying this need, this dissertation proposes a novel technique, called request-flow comparison, for automatically localizing the sources of performance changes from the myriad potential culprits in a distributed system to just a few potential ones. Request-flow comparison works by contrasting the workflow of how individual requests are serviced within and among every component of the distributed system between two periods: a non-problem period and a problem period. By identifying and ranking performance-affecting changes, request-flow comparison provides developers with promising starting points for their diagnosis efforts. Request workflows are obtained with less than 1% overhead via use of recently developed end-to-end tracing techniques. 
To demonstrate the utility of request-flow comparison in various distributed systems, this dissertation describes its implementation in a tool called Spectroscope and describes how Spectroscope was used to diagnose real, previously unsolved problems in the Ursa Minor distributed storage service and in select Google services. It also explores request-flow comparison's applicability to the Hadoop File System. Via a 26-person user study, it identifies effective visualizations for presenting request-flow comparison's results and further demonstrates that request-flow comparison helps developers quickly identify starting points for diagnosis. This dissertation also distills design choices that will maximize an end-to-end tracing infrastructure's utility for diagnosis tasks and other use cases.
Infidelity of DNA synthesis associated with bypass of apurinic sites. (1983)

The mutagenic potential of apurinic sites in vivo has been studied by transfection of depurinated phi X174 DNA containing amber mutations into SOS-induced Escherichia coli spheroplasts. Mutagenicity is abolished by treatment of the depurinated DNA with an apurinic endonuclease from Hela cells, establishing the apurinic site as the mutagenic lesion. The frequency of copying apurinic sites in vitro was analyzed by measuring the extent of DNA synthesis using E. coli DNA polymerase I and avian myeloblastosis DNA polymerase. The inhibition of DNA synthesis by apurinic sites was less with avian myeloblastosis DNA polymerase, suggesting that this error-prone enzyme copies apurinic sites with greater frequency. Consistent with this conclusion is the observation that, upon transfection into (normal) spheroplasts, the reversion frequency of depurinated phi X174 am3 DNA copied with avian myeloblastosis virus DNA polymerase is much greater than that of the same DNA copied with E. coli DNA polymerase I. Sequence analysis of the DNA of 33 revertant phage produced by depurination indicates a preference for incorporation of deoxyadenosine opposite putative apurinic sites. The combined results indicate that mutagenesis resulting from apurinic sites is associated with bypass of these noncoding lesions during DNA synthesis.
One-Trip Sand Control-Completion Technology That Eliminates Perforation Damage While Reducing Rig Time (2005)

Abstract Formation damage caused by the perforating process is often found to be one of the leading contributors to poor productivity. Fractured and compacted zones, perforation gun debris, and broken formation blockages are common types of damage that can occur inside the perforation tunnel. Reducing or eliminating initial perforation damage can result in a more productive well over its lifetime. This paper examines a completely new technology for perforating wells in unconsolidated formations that eliminates explosive perforation discharges and its associated formation damage risk. This new technology also reduces the cost of well construction by eliminating the need for perforating and by allowing the production liner and primary cementing equipment to be run in a single trip with an effective means of sand control. The tool system uses telescoping tubes that extend from the liner to the formation by hydraulic pressure and mechanical force. Once the tubes are extended (or telescoped), the liner is cemented in place. The tubes form a conduit from the formation to the casing ID and contain sand-control media. This new completion method eliminates gravel packing and minimizes intervention in completion operations, saving substantial rig time. The system does not require large fluid-pumping treatments with high horsepower requirements, which simplifies operational logistics especially in remote or offshore environments. Formation damage can also be caused by drilling mud and fluid-loss control measures after completion. This new perforating method eliminates both of these highly damaging mechanisms because the tubes extend out past the damage and into the formation, even in a washed out hole. This paper describes the new system, cost comparisons with existing methods, and expected economic benefits over the lifetime of wells in typical applications of this new technology.