gebhart/patrepeval huggingface dataset:
Evaluation of Polytetrafluoroethylene Micrografts in Microvascular Surgery (2002)

Interposition grafts are an important and invaluable technique in free microvascular tissue transfer as they extend the vascular pedicle to allow it to reach undisturbed donor vessels away from the surgical or traumatic site. Autologous vein has been the most commonly used material for interposition grafting, but it has significant disadvantages. Nonautologous grafts are readily available and could certainly remedy most of the autologous graft disadvantages. This study was designed to (1) evaluate the patency of expanded polytetrafluoroethylene (PTFE) grafts in a simple microvascular vessel repair and (2) evaluate the survival of microvascular free flaps using PTFE arterial interposition grafts. The inferior epigastric vein or PTFE was used to reconstruct the femoral artery in 10 animals (20 sides) in a simple vessel repair model and in 20 animals in a groin free flap model. All epigastric vein grafts were patent at 1 week in the vessel repair group. Only five in the PTFE vessel repairs were patent. Nine of 10 free flaps were viable in the free flap group with epigastric vein interposition. All of the 10 free flaps with PTFE interposition failed. There was a statistically significant difference in vessel patency between PTFE grafts in the vessel repair and free flap models. Our data show that PTFE microvascular grafts are a poor substitute for vein grafts in the vessel repair and free flap animal models. We also found that simple vessel repair is not an acceptable model to study manipulations intended for free tissue transfer.
Skin Collagen Synthesis Is Depressed in Patients with Severe Sepsis (2010)

Skin collagen synthesis is depressed during severe sepsis and is followed by a compensatory response 3 and 6 months after the onset of sepsis.
Visible-Band Chiroptical Meta-devices with Phase-Change Adjusted Optical Chirality (2022)

Low-cost large-area chirality meta-devices (CMDs) with adjustable optical chirality are of great interest for polarization-sensitive imaging, stereoscopic display, enantioselectivity analysis, and catalysis. Currently, CMDs with adjusted chiroptical responses in the mid-infrared to terahertz band have been demonstrated by exploiting photocarriers of silicon, pressure, and phase-change of GSTs but are still absent in the visible band, which in turn limits the development of chiral nanophotonic devices. Herein, by employing a phase-change material (Sb<sub>2</sub>S<sub>3</sub>), we present a protocol for the fabrication of wafer-scale visible-band enantiomeric CMDs with handedness, spectral, and polarization adjustability. As measured by circular dichroism, the chirality signs of CMDs enantiomers can be adjusted with Sb<sub>2</sub>S<sub>3</sub> from amorphous to crystalline, and the chirality resonance wavelength can also be adjusted. Our results suggest a new type of meta-devices with adjustable chiroptical responses that may potentially enable a wide range of chirality nanophotonic applications including highly sensitive sensing and surface-enhanced nanospectroscopy.
Building a secure distributed computer system (1988)

This dissertation shows that it is practical to build a distributed computer system that is both secure and usable. For the system to be secure, it must protect network communication and permit the secure mutual identification of communicating parties. Together these two functions allow servers to control access to the resources of the system and to maintain the integrity and privacy of users' data. For the system to be usable, its performance must be comparable to its insecure counterpart and its security mechanisms and services must be transparent to users.
The dissertation describes the architecture and implementation of a secure distributed computer system based on the Mach operating system. Secure network communication in the system is the responsibility of network server tasks in combination with key distribution servers. An authentication service provides the means for secure mutual identification of communicating parties as well as support for access control. A secure name service permits clients to locate and authenticate servers in a single operation. Given these security services, users can build secure distributed applications easily. In addition the system supports secure nested server invocations in which servers access other servers on behalf of users.
The resulting distributed computer system is shown to be secure and to be unable with respect to both performance and transparency. The system is demonstrated to be secure by examining the possible attacks that can be made against the system and showing how they are prevented. The performance of the system is shown to be comparable to its insecure counterpart apart from those costs directly attributable to data encryption. The system is shown to provide transparency by demonstrating that the details of the security mechanisms and services are hidden from users.
The main contributions of this dissertation are: the design and implementation of a secure distributed computer system that is as usable as its insecure counterpart; a complete description of the architecture of a secure distributed computer system; the secure extension of the Mach communication facility into the network environment; and a secure distributed computer system that provides more flexibility than other secure distributed computer systems.
Analgesic effect of topically applied pranoprofen-gel. (1985)

The analgesic effect of topically applied pranoprofen-gel (1% and 3%) was investigated in comparison with indomethacin-gel in experimental animals. Applied topically, 1% and 3% pranoprofen-gel inhibited the inflammatory pain induced by Randall and Selitto's method and the pain response (abnormal gait) of concanavalin A-induced arthritis in rats dose-dependently. Furthermore, in antigen (methylated bovine serum albumin)-induced arthritis in rats, pranoprofen-gel had a concentration and application-dependent therapeutic effect on knee joint swelling and the pain response. Pranoprofen-gel had a stronger analgesic effect than indomethacin-gel in these experimental models. Both drugs inhibited the flexor reflexes of the hind limb induced by injecting bradykinin (BK) in combination with arachidonic acid into the common iliac artery of the spinal rat, but failed to do so with BK combined with prostaglandin E2 (PGE2). Moreover, pranoprofen-gel inhibited the BK-induced increase in the firing rate of the saphenous nerve of the spinal cat. These results show that pranoprofen-gel, applied topically, permeates well from the skin to the nociceptor site, relieving the hyperalgesia caused by PGs-induced sensitization of pain receptors by inhibiting their production. As a topical anti-inflammatory and analgesic agent, pranoprofen-gel is at least as effective as indomethacin-gel, so that it should have good clinical potential.
Machine Learning for Creativity: Using Similarity Networks to Design Better Crowdfunding Projects (2021)

A fundamental tension exists in creativity between novelty and similarity. This paper exploits this tension to help creators craft successful projects in crowdfunding. To do so, we apply the concept of combinatorial creativity, analyzing each new project in connection to prior similar projects. By using machine learning techniques (Word2vec and Word Mover’s Distance), we measure the degrees of similarity between crowdfunding projects on Kickstarter. We analyze how this similarity pattern relates to a project's funding performance. We find: (i) the prior level of success of similar projects strongly predicts a new project's funding performance, (ii) the funding performance increases with a balance between being novel and imitative, (iii) the optimal level for funding goal is close to the funds raised by prior similar projects, and (iv) the funding performance increases with a balance between atypical and conventional imitation. We use these findings to generate actionable recommendations for project creators and crowdfunding platforms.
Use of 64-Row Multidetector CT Angiography in Blunt and Penetrating Trauma of the Upper and Lower Extremities (2009)

Computed tomographic (CT) angiography is rapidly becoming the preferred imaging test for the initial evaluation of patients suspected to have arterial injuries after blunt and penetrating trauma to the extremities. The increasingly widespread use of 64-row multidetector CT technology offers considerable benefits in extremity CT angiography in the trauma setting. These include the ability to generate isotropic data sets of long vascular territories, with the acquisition performed in a short time (10 seconds or less). Isotropic voxels make CT a fully multiplanar modality, a capability that is particularly useful for evaluating tortuous vessels. Sixty-four-row multidetector CT angiography of the extremities has the ability to demonstrate a variety of vascular injuries such as occlusion, pseudoaneurysm, active extravasation, and intimal dissection. Radiologists should be aware of the various potential pitfalls and limitations of extremity CT angiography in evaluation of trauma patients suspected to have extremity vascular injuries, including inadequate arterial enhancement, motion artifact, inadequate positioning, and streak artifact. By demonstrating the extent, location, and type of injury, CT angiography aids in the decision-making process to determine the appropriate management for each injury in each patient.
Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry (2018)

Polypeptide vaccines effectively activate human T cells but suffer from poor biological stability, which confines both transport logistics and in vivo therapeutic activity. Synthetic biology has the potential to address these limitations through the generation of highly stable antigenic "mimics" using subunits that do not exist in the natural world. We developed a platform based on D-amino acid combinatorial chemistry and used this platform to reverse engineer a fully artificial CD8+ T cell agonist that mirrored the immunogenicity profile of a native epitope blueprint from influenza virus. This nonnatural peptide was highly stable in human serum and gastric acid, reflecting an intrinsic resistance to physical and enzymatic degradation. In vitro, the synthetic agonist stimulated and expanded an archetypal repertoire of polyfunctional human influenza virus-specific CD8+ T cells. In vivo, specific responses were elicited in naive humanized mice by subcutaneous vaccination, conferring protection from subsequent lethal influenza challenge. Moreover, the synthetic agonist was immunogenic after oral administration. This proof-of-concept study highlights the power of synthetic biology to expand the horizons of vaccine design and therapeutic delivery.
Hydrodynamic conditions affect the proteomic profile of marine biofilms formed by filamentous cyanobacterium (2022)

Proteomic studies on cyanobacterial biofilms can be an effective approach to unravel metabolic pathways involved in biofilm formation and, consequently, obtain more efficient biofouling control strategies. Biofilm development by the filamentous cyanobacterium Toxifilum sp. LEGE 06021 was evaluated on different surfaces, glass and perspex, and at two significant shear rates for marine environments (4 s<sup>-1</sup> and 40 s<sup>-1</sup>). Higher biofilm development was observed at 4 s<sup>-1</sup>. Overall, about 1877 proteins were identified, and differences in proteome were more noticeable between hydrodynamic conditions than those found between surfaces. Twenty Differentially Expressed Proteins (DEPs) were found between 4 s<sup>-1</sup> vs. 40 s<sup>-1</sup>. On glass, some of these DEPs include phage tail proteins, a carotenoid protein, cyanophynase glutathione-dependent formaldehyde dehydrogenase, and the MoaD/ThiS family protein, while on perspex, DEPs include transketolase, dihydroxy-acid dehydratase, iron ABC transporter substrate-binding protein and protein NusG. This study contributes to developing a standardized protocol for proteomic analysis of filamentous cyanobacterial biofilms. This kind of proteomic analysis can also be useful for different research fields, given the broad spectrum of promising secondary metabolites and added-value compounds produced by cyanobacteria, as well as for the development of new antibiofilm strategies.
Adiponectin Gene Polymorphism Is Selectively Associated with the Concomitant Presence of Metabolic Syndrome and Essential Hypertension (2011)

ADIPOQ genetic variants were selectively and specifically associated with the concomitant presence of MetS and HTN, suggesting potential genetic linkage between MetS and HTN.
Interplay between thermal transfers and degradation of the bronchial epithelium during exercise (2019)

info:eu-repo/semantics/published
On the connectivity assumption of non-linear flocking models (2013)

The problem of collective behavior of autonomous agents is discussed. Based on state dependent communication graphs we analyze a family of non-linear flocking models by establishing sufficient initial conditions so as connectivity and thus asymptotic flocking is ensured. We discuss models with non-linear uniformly bounded connection rates with and without delays.
Images du labyrinthe (2008)

Réflexions sur la signification et la fonction de l'art, à travers notamment un dialogue mené avec André Malraux sur la notion de musée imaginaire. Ces textes sont consacrés notamment à Carzou, Raoul Ubac, Alechinsky, Picasso.
Ontology-Enriched Query Answering on Relational Databases (2021)

We develop a flexible, open-source framework for query answering on relational databases by adopting methods and techniques from the Semantic Web community and the data exchange community, and we apply this framework to a medical use case. We first deploy module-extraction techniques to derive a concise and relevant sub-ontology from an external reference ontology. We then use the chase procedure from the data exchange community to materialize a universal solution that can be subsequently used to answer queries on an enterprise medical database. Along the way, we identify a new class of well-behaved acyclic EL-ontologies extended with role hierarchies, suitably restricted functional roles, and domain/range restrictions, which cover our use case. We show that such ontologies are C-stratified, which implies that the chase procedure terminates in polynomial time. We provide a detailed overview of our real-life application in the medical domain and demonstrate the benefits of this approach, such as discovering additional answers and formulating new queries.
Synthesis, stability, and subcellular distribution of major histocompatibility complex class II molecules in Langerhans cells infected with Leishmania major (1997)

Protozoan parasites of the genus Leishmania exist as obligatory intracellular amastigotes and invade macrophages and Langerhans cells, the dendritic cells of the skin. Langerhans cells are much more efficient in presenting Leishmania major antigen to T cells than macrophages are and have the unique ability to retain parasite antigen in immunogenic form for prolonged periods. To analyze the mechanisms that are responsible for this potency, we defined the synthesis, turnover, conformation, and localization of major histocompatibility complex (MHC) class II molecules in Langerhans cells. Hence, Langerhans cells were pulse-labeled; immunoprecipitation of MHC class II molecules and gel electrophoresis followed. In addition, the subcellular distribution of MHC class II molecules in L. major-infected Langerhans cells was analyzed by confocal microscopy. The results show that (i) newly synthesized MHC class II molecules are required for L. major antigen presentation by Langerhans cells, (ii) MHC class II-peptide complexes in Langerhans cells are long-lived, (iii) phagocytosis of L. major modulates MHC class II biosynthesis by reducing its downregulation during Langerhans cell differentiation, and (iv) newly synthesized MHC class II molecules are associated with the parasitophorous vacuole of infected Langerhans cells. These findings support the conclusion that the traits of MHC class II expression correspond to the highly specialized functions of Langerhans cells in the immunoregulation of cutaneous leishmaniasis.
Efficient Synthesis of [11C]Ramelteon as a Positron Emission Tomography Probe for Imaging Melatonin Receptors Involved in Circadian Rhythms (2011)

Ramelteon (TAK-375) is a novel melatonin receptor agonist that is used for clinical treatment of insomnia. The present report describes radiolabeling of ramelteon with the short-lived positron-emitter ¹¹C (T(1/2)=20.4 min) by 2 methods. One method was [¹¹C]methylation of an acetoamide precursor and the other was [¹¹C]acylation of the corresponding amine precursor. First, [¹¹C]methylation method showed the low reproducibility together with the production of many kinds of side products from which the [¹¹C-methyl]Ramelteon was separated with chemical purity of <28% and radiochemical purity of >98%. Whereas, the [¹¹C]acylation method showed high efficiency and reproducibility with a good radiochemical yield (22-43%, decay corrected), high chemical and radiochemical purities (>99% each), and high specific activity (43-162 GBq/µmol) (n=5) after HPLC purification. [¹¹C]Ramelteon is a potential positron emission tomography (PET) probe for imaging the melatonin receptor.
Strength of Synthetic Fiber Ropes Degraded by Repetitive Bending (2015)

A synthetic fiber rope which has lightweight, high tensile strength and flexibility is receiving a lot of attention as the replacement for a stainless steel wire rope. This paper takes note of durability of repetitive bending. We performed an experiment with two synthetic fiber ropes and one stainless steel wire rope in conformity with Japanese Industrial Standards. As a result, the stainless steel wire rope and one synthetic fiber rope which has high resistance to frictional wear didn't get loss of tensile strength. However, repeated bending causes the tensile strength deterioration of the other synthetic fiber rope which is weak in frictional wear.
Design and synthesis of fluorescent ?-cyclodextrins for the enantioselective sensing of ?-amino acids (2003)

Fluorescent monofunctionalized beta-cyclodextrins bearing a copper(II) binding side arm and a dansyl group (CD-NH-AA-CH(2)CH(2)NH-DNS) were designed as enantioselective sensors for unmodified alpha-amino acids. The side arm was derived from amino acid synthons (AA = L- and D-phenylalanine (1 and 2), L- and D-phenylglycine (3 and 4), L-proline (5), and L-cyclohexylglycine (6)) and was chosen in order to contain an amide, an amine, and a sulphonamide group. Enantioselectivity was evaluated by addition of copper(II) complexes of D- or L-valine and D- or L-proline. Chiral discrimination in the fluorescence response was observed in all cases, due to a ligand exchange process. The best conditions for these experiments were found to be the use of an excess (10:1) of the copper complex. The cyclodextrin 4 containing a D-phenylglycine unit was found to be poorly enantioselective, as found for 2, suggesting that the best design can be obtained by using L-amino acids. All L-amino acid containing cyclodextrins showed good enantioselectivities, some of which were higher than those already reported for 1. Other analytes related to amino acids were studied using cyclodextrins 1 and 3. Enantiomers of alpha,alpha-disubstituted amino acids, N-methylamino acids, and amino acid amides were found to be discriminated, while beta-phenylalanine and other molecules bearing a poor anchoring group at the alpha-carbon gave poor enantioselectivity. On the basis of the present data a model for the recognition process, based on the formation of ternary diastereomeric complexes, is proposed.
KESZTYŰS LÓRÁND KÓRÉLETTAN PROFESSZOR, AZ 1951-BEN FÜGGTLENNÉ VÁLT DEBRECENI ORVOSTUDOMÁNYI EGYETEMNEK DÉKÁNKÉNT ELSŐ VEZETŐJE, MAJD KÉTSZER (1959-1963, 1967-1973) ANNAK REKTORA (2022)

Kesztűs Lóránd 1951-ben dékánként első vezetője lett a Debreceni Tudományegyem Orvostudományi Karából alakult Debreceni Orvostudományi Egyetemnek, amely még két időszakra (1959-1963, 1967-1973) rektorának választotta. Meghatározó szerepe volt az új intézmény intézetei és klinikái infrastruktúrális bővítésében, a növekvő hallgatói létszámú orvosképzés korszerűsítésében, a tudományos kutatások eredményességének növelésében, a regionális és országos szakmai tekintélyű klinikai betegellátás fejlesztésében, a centralizált pártállami politikai rendszer korlátai között teljesítmény alapú, demokratikus intézményirányítás kialakításában. Nemzetközileg elismert kutatási eredményeivel és tudománypolitikai tevékenységével a hazai immunológiai és allergológiai kutatások megalapozója. A Magyar Tudományos Akadémia tagjává választották. Intézetalapító és szervező, tankönyvírói és iskolateremtő munkásságával a kórélettan korszakos jelentőségű professzora. Barátságos, közvetlen és nyitott személyiségének fontos szerepe volt az eredményes, sikeres munkát biztosító intézeti és egyetemi alkotó légkör megvalósulásában. Életpályájának bemutatása volt közvetlen munkatársa monográfiáján alapszik és tartalmazza három másik professzor (ketten korábbi rektorok) visszaemlékezését.
Initiator-Fragment Incorporation Radical Polymerization of Divinyl Adipate with Dimethyl 2,2‘-Azobis(isobutyrate):  Kinetics and Formation of Soluble Hyperbranched Polymer (2005)

The polymerization of divinyl adipate (DVA) as an effective cross-linker with dimethyl 2,2‘-azobis(iosbutyrate) (MAIB) was performed at 70 and 80 °C in benzene. When the MAIB concentrations as high as 0.05−0.50 mol/L were used, the polymerization of DVA (0.30 mol/L) proceeded homogeneously at 80 °C without any gelation to give soluble polymers in the yields of 45−87%. Kinetic investigation on the homogeneous polymerization at 70 °C gave the following rate equation: Rp = k[MAIB]0.3[DVA]1.7 (Rp = initial polymerization rate), indicating a significant contribution of the primary radical termination. The overall activation energy of the polymerization was estimated to be 26.8 kcal/mol. The polymer formed in the polymerization of DVA (0.30 mol/L) with MAIB (0.50 mol/L) at 80 °C for 4 h was composed of the DVA units without (48 mol %) and with (8 mol %) double bond and the methoxycarbonylpropyl group (44 mol %) from MAIB. The large fraction of the incorporated initiator-fragment implies that an initiator-fragment incorporation polymerization proceeded to give hyperbranched polymer in the present polymerization. The results of the multiangle laser light scattering and viscometric measurements and also transmission electron microscopic observation indicate that the polymer was of compact hyperbranched structure. The polymer showed an upper critical solution temperature (36 °C on cooling) in an acetone−water [7:40 (v/v)] mixture and also exhibited the encapsulation and transport properties for Rhodamine 6G as a dye probe.
New small γ-turn type N-primary amino terminal tripeptide organocatalyst for solvent-free asymmetric aldol reaction of various ketones with aldehydes (2021)

New small γ-turn type <i>N</i>-primary amino terminal tripeptides were synthesized and their functionality as an organocatalyst was examined in the asymmetric aldol reaction of various ketones with different aromatic aldehydes under solvent-free neat conditions to afford the desired chiral <i>anti</i>-aldol products in good to excellent chemical yields, diastereoselectivities and enantioselectivities (up to 99%, up to <i>syn</i> : <i>anti</i>/13 : 87 dr, up to 99% ee).