gebhart/patrepeval huggingface dataset:
Chelators affecting iron absorption in mice. (1990)

The effect of natural and synthetic chelators on iron (59Fe) absorption in mice has been studied in three different experiments using single or repeated intragastric administrations of chelator iron (59Fe) complexes of different chelator doses. The amount of 59Fe in whole animals, their excretions and also distribution of 59Fe in blood, liver, spleen and heart was measured at one, three and eight weeks following the 59Fe-chelator administrations and compared to controls which received the same amount of iron (59Fe) but no chelator. 2-Hydroxy-4-methoxypyridine-1-oxide and maltol, which form lipophilic iron complexes, were found to cause an increase of 59Fe absorption while other chelators caused a decrease either by precipitating iron eg. 2-hydroxypyridine-1-oxide or by forming non absorbable soluble iron complexes eg. desferrioxamine, mimosine, EDTA. 1,2-Dimethyl-3-hydroxypyrid-4-one caused a decrease in iron absorption at a high dose (10 mg) by comparison to the control group but it did not significantly alter iron absorption at a lower dose (2 mg). It is suggested that natural and synthetic iron chelating compounds influence the absorption of iron and some may have a use in the treatment of diseases associated with gastro-intestinal iron absorption imbalance.
Blade-Row Interaction in an Axial-Flow Subsonic Compressor Stage (1980)

This paper contains the results of the measurements of fluctuating pressures on the mid-span profile surfaces of both rotor and stator blades for several points of operation. By the aid of rotating probes behind the rotor, the shapes of the rotor wakes were measured, too. All the measurements have been performed twice, at first with guide vanes in front of the rotor, and afterwards without the latter. The results of the measurements are evaluated with respect to the parameters involved, like Strouhal-number, reduced frequency, and circumferential Mach number. The flow analysis is done for various wake-fields behind the rotor correspondent to different operation points. Emphasis is given to the establishment of correlations for the blade-row interaction and to the comparison of the measured pressure distributions with computed results according to well-known theoretical approaches.
Effect of music of specific frequency upon the sleep architecture and electroencephalographic pattern of individuals with delayed sleep latency: A daytime nap study (2019)

It was concluded that 432 Hz music has some significant calming effect as reflected by increased alpha activities without any significant effect upon the sleep latency in the daytime naps.
The Invertebrate Defence Molecule Coelomic Cytolytic Factor, a Functional Analog of the Cytokine Tumour Necrosis Factor‐α, Interacts with Mammalian Cells through its Lectin‐Like Domain (2004)

Coelomic cytolytic factor (CCF) is a 42 kDa invertebrate pattern recognition molecule isolated from the coelomic fluid of the earthworm Eisenia foetida (Oligochaeta, Annelida). CCF displays a number of similarities with the mammalian cytokine tumour necrosis factor‐α (TNF‐α) as a result of a shared N,N ′‐diacetylchitobiose lectin‐like domain. However, these similarities are solely functional and are not based on any (DNA or amino acid) sequence homology, thus suggesting a form of convergent evolution. In particular, the lectin‐like domain of TNF‐α has been shown to induce membrane depolarization in various mammalian cell types, through interactions with endogenous amiloride‐sensitive ion channels. This nonreceptor‐mediated activity of TNF‐α has been reported to be involved in the resorption of oedema. Likewise, the lectin‐like domain of CCF also induces membrane depolarization in mammalian cells. Here, we show that CCF appears to be able to induce oedema resorption in an alveolar epithelial cell line through its lectin‐like domain. This lectin‐like domain of CCF interacts (directly or indirectly) with endogenous sodium and/or chloride channels, and not potassium channels, on mammalian cells. Additionally, we suggest that the JNK/SAPK and Erk1/2 pathways are involved in CCF‐induced macrophage activation. These results further establish the functional analogy between an invertebrate pattern recognition molecule and a mammalian cytokine and, from a more applied point of view, suggest the possibility of utilizing CCF in the treatment of oedema.
Compressed Video Action Recognition (2018)

Training robust deep video representations has proven to be much more challenging than learning deep image representations. This is in part due to the enormous size of raw video streams and the high temporal redundancy; the true and interesting signal is often drowned in too much irrelevant data. Motivated by that the superfluous information can be reduced by up to two orders of magnitude by video compression (using H.264, HEVC, etc.), we propose to train a deep network directly on the compressed video. This representation has a higher information density, and we found the training to be easier. In addition, the signals in a compressed video provide free, albeit noisy, motion information. We propose novel techniques to use them effectively. Our approach is about 4.6 times faster than Res3D and 2.7 times faster than ResNet-152. On the task of action recognition, our approach outperforms all the other methods on the UCF-101, HMDB-51, and Charades dataset.
Functional Neurologic and Surgical Outcomes Among Patients Undergoing Reoperation for Craniopharyngioma Recurrence (2020)

Aabedi, Alexander A BS; Young, Jacob S MD; Phelps, Ryan R.L BA; Winkler, Ethan A MD, PhD; Theodosopoulos, Philip V MD Author Information
Reactivity of magnesium oxide in different chlorinating gas mixtures (1998)

International audience
Properly Oriented Heparin−Decasaccharide-Induced Dimers Are the Biologically Active Form of Basic Fibroblast Growth Factor (1997)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionProperly Oriented Heparin−Decasaccharide-Induced Dimers Are the Biologically Active Form of Basic Fibroblast Growth FactorFranklin J. Moy, Michal Safran, Andrew P. Seddon, Doug Kitchen, Peter Böhlen, David Aviezer, Avner Yayon, and Robert PowersCite this: Biochemistry 1997, 36, 25, 7936Publication Date (Web):June 24, 1997Publication History Published online24 June 1997Published inissue 1 June 1997https://pubs.acs.org/doi/10.1021/bi975007ghttps://doi.org/10.1021/bi975007gcorrectionACS PublicationsCopyright © 1997 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views398Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Get e-Alertsclose Get e-Alerts
MCMI-ANFIS: A robust multi class multiple instance Adaptive Neuro-Fuzzy Inference System (2016)

Fuzzy logic is a powerful tool to model knowledge uncertainty, measurements imprecision, and vagueness. However, there is another type of vagueness that arises when data have multiple forms of expression. This is the case for multiple instance learning problems (MIL). In MIL, an object is represented by a collection of instances, called a bag. Labels of bags are known but not those of individual instances. In previous work, we have introduced MI-ANFIS, a Multiple Instance-ANFIS, that extends the standard Adaptive Neuro Fuzzy Inference System (ANFIS) to handle reasoning with bags of instances as input and capable of learning from ambiguously labeled data. In this paper, first, we present a regularization technique, we called Rule Dropout, and show that it could be used to train MI-ANFIS systems with better generalization. Next, we develop a multi class MI-ANFIS (MCMI-ANFIS), that could be used to solve multiple class classification problems effectively. The proposed MCMI-ANFIS is tested and validated using a benchmark data set suitable for multiple class MIL problems.
Comparison of carbohydrate, lignin, and protein ratios between grass species by cross polarization-magic angle spinning carbon-13 nuclear magnetic resonance (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of carbohydrate, lignin, and protein ratios between grass species by cross polarization-magic angle spinning carbon-13 nuclear magnetic resonanceDavid S. Himmelsbach, Franklin E. Barton II, and William R. WindhamCite this: J. Agric. Food Chem. 1983, 31, 2, 401–404Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://pubs.acs.org/doi/10.1021/jf00116a054https://doi.org/10.1021/jf00116a054research-articleACS PublicationsRequest reuse permissionsArticle Views224Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Determination of Residues Involved in Ligand Binding and Signal Transmission in the Human IFN-α Receptor 2 (1999)

Abstract The human IFN-α receptor (hIFNAR) is a complex composed of at least two chains, hIFNAR1 and hIFNAR2. We have performed a structure-function analysis of hIFNAR2 extracellular domain regions using anti-hIFNAR2 mAbs (1D3, 1F3, and 3B7) and several type I human IFNs. These mAbs block receptor activation, as determined by IFN-stimulated gene factor 3 formation, and block the antiviral cytopathic effects induced by type I IFNs. We generated alanine substitution mutants of hIFNAR2-IgG and determined that regions of hIFNAR2 are important for the binding of these blocking mAbs and hIFN-α2/α1. We further demonstrated that residues E78, W101, I104, and D105 are crucial for the binding of hIFN-α2/α1 and form a defined protrusion when these residues are mapped upon a structural model of hIFNAR2. To confirm that residues important for ligand binding are indeed important for IFN signal transduction, we determined the ability of mouse L929 cells expressing hIFNAR2 extracellular domain mutants to mediate hIFN signal. hIFN-α8, previously shown to signal a response in L929 cells expressing hIFNAR1, was unable to signal in L929 cells expressing hIFNAR2. Transfected cells expressing hIFNAR2 containing mutations at residues E78, W101, I104, or D105 were unresponsive to hIFN-α2, but remained responsive to hIFN-β. In summary, we have identified specific residues of hIFNAR2 important for the binding to hIFN-α2/1 and demonstrate that specific regions of the IFNAR interact with the subspecies of type I IFN in different manners.
Multidimensional object acquisition by single-shot phase imaging with a coded aperture (2015)

We propose a generalized framework for quantitatively acquiring multidimensional complex objects based on single-shot phase imaging with a coded aperture (SPICA). In multidimensional SPICA, a propagating field from a multidimensional complex object is sieved by a coded aperture, the sieved field is modulated by an optical element, which is called coding optics, and then the resultant field is captured by a monochrome image sensor. The original complex field is reconstructed from the single captured intensity image by a phase retrieval algorithm with a support constraint of the coded aperture and a sparsity-based reconstruction algorithm based on compressive sensing. We also present theoretical conditions for the proposed method. As a demonstration, we numerically verified an application of this generalized framework for single-shot acquisition of depth-variant multispectral objects.
First Synthesis of Nonracemic (R)-(+)-Myrmicarin 217 (2000)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTFirst Synthesis of Nonracemic (R)-(+)-Myrmicarin 217Babak Sayah, Nadia Pelloux-Léon, and Yannick ValléeView Author Information LEDSS, Université Joseph Fourier - CNRS, B.P. 53, 38041 Grenoble, France Cite this: J. Org. Chem. 2000, 65, 9, 2824–2826Publication Date (Web):April 6, 2000Publication History Received6 December 1999Published online6 April 2000Published inissue 1 May 2000https://pubs.acs.org/doi/10.1021/jo9918697https://doi.org/10.1021/jo9918697brief-reportACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views954Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical synthesis,Ketones,Organic compounds,Pyrroles,Substituents Get e-Alerts
Early transplantation of an encapsulated glial cell line—derived neurotrophic factor—producing cell demonstrating strong neuroprotective effects in a rat model of Parkinson disease (2005)

These neuroprotective effects may be related to glial proliferation and signaling via the GDNF receptor alpha1. The results of this study support a role for this grafting technique in the treatment of PD.
Cysteine String Proteins Are Associated with Chromaffin Granules (1996)

In this work, we have examined the subcellular distribution of cysteine string proteins (Csps) in bovine adrenal medullary chromaffin cells. Csps did not leak from digitonin-permeabilized chromaffin cells, suggesting that there is no cytosolic pool of the protein in these cells. Subcellular fractionation studies confirmed that there was essentially no Csp immunoreactivity in the cytosolic fraction. However, immunoreactivity was detected in the membrane fractions of these cells. Csp immunoreactivity codistributed with dopamine beta-hydroxylase, a granule marker protein, in sucrose gradient-separated granule fractions. Immunofluorescence studies showed that all chromaffin cells in culture were stained with a punctate appearance consistent with a granular localization. These results were confirmed by immunogold labeling, which demonstrated specific labeling of chromaffin granule membranes. In addition to its presence on synaptic vesicles, cysteine string protein is therefore a bona fide chromaffin granule membrane protein.
Acetylcholine receptor clustering and nuclear movement in muscle fibers in culture. (1987)

We have studied the formation of acetylcholine receptor (AChR) clusters and the behavior of myonuclei in rat and chick skeletal muscle cells grown in cell culture. These cells were treated with a factor derived from Torpedo electric extracellular matrix, which causes a large increase in their number of AChR clusters. We found that these clusters were located preferentially in membrane regions above myonuclei. This cluster-nucleus colocalization is explained by our finding that most of the nuclei near clusters remain relatively stationary, while most of those away from clusters are able to translocate throughout the myotube. In some cases, clusters clearly formed first, then nuclei migrated underneath and became immobilized. If clustered AChRs later dispersed, their associated nuclei resumed moving. These results suggest that AChR clustering initiates an extensive cytoskeletal rearrangement that causes the subcluster localization of organelles, potentially providing a stable source of newly synthesized AChRs for insertion into the cluster.
Fringe projection 3D microscopy with the general imaging model (2015)

Three-dimensional (3D) imaging and metrology of microstructures is a critical task for the design, fabrication, and inspection of microelements. Newly developed fringe projection 3D microscopy is presented in this paper. The system is configured according to camera-projector layout and long working distance lenses. The Scheimpflug principle is employed to make full use of the limited depth of field. For such a specific system, the general imaging model is introduced to reach a full 3D reconstruction. A dedicated calibration procedure is developed to realize quantitative 3D imaging. Experiments with a prototype demonstrate the accessibility of the proposed configuration, model, and calibration approach.
The Recombinant Expression Proteins FnBP and ClfA From Staphylococcus aureus in Addition to GapC and Sip From Streptococcus agalactiae Can Protect BALB/c Mice From Bacterial Infection (2021)

Dairy cow mastitis is a serious disease that is mainly caused by intramammary infection with <i>Staphylococcus aureus</i> and <i>Streptococcus agalactiae</i> [group B streptococcus (GBS)]. FnBP and ClfA are the virulence factors of <i>S. aureus</i>, while GapC is the respective factor for <i>S. agalactiae</i>. Sip is a highly immunogenic protein, and it is conserved in all GBS serotypes. In this study, we analyzed the abovementioned four genes prepared a FnBP+ClfA chimeric protein (FC), a GapC+Sip chimeric protein (GS), and a FnBP+ClfA+GapC+Sip chimeric protein (FCGS) based on the antigenic sites to evaluate their use in vaccine development. After expression and purification of the recombinant proteins in <i>Escherichia coli</i>, BALB/c mice were immunized with them to examine resistance effects. The total lethal and half lethal doses of <i>S. aureus</i> and <i>S. agalactiae</i> were then measured, and the immunoprotective effects of the fusion proteins were evaluated. The FC and FCGS chimeric proteins could induce mice to produce high levels of antibodies, and bacterial loads were significantly reduced in the spleens and livers after challenge. After immunization with FCGS, the recipients resisted the attacks of both <i>S. aureus</i> and <i>S. agalactiae</i>, indicating the potential of the fusion protein as a mastitis vaccine.
Extra-Articular Distal-Third Diaphyseal Fractures of the Humerus (2006)

For extra-articular distal-third diaphyseal humeral fractures, operative treatment achieves more predictable alignment and potentially quicker return of function but risks iatrogenic nerve injury and infection and the need for reoperation. Functional bracing can be associated with skin problems and varying degrees of angular deformity, but function and range of motion are usually excellent.
CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network (2011)

The slow rate at which pharmacogenetic tests are being adopted in clinical practice is partly due to the lack of specific guidelines on how to adjust medications on the basis of the genetic test results. One of the goals of the Clinical Pharmacogenetics Implementation Consortium (CPIC) of the National Institutes of Health's Pharmacogenomics Research Network (http://www.pgrn.org) and the Pharmacogenomics Knowledge Base (PharmGKB, http://www.pharmgkb.org) is to provide peer-reviewed, updated, evidence-based, freely accessible guidelines for gene/drug pairs. These guidelines will facilitate the translation of pharmacogenomic knowledge from bench to bedside. Clinical Pharmacology & Therapeutics (2011) 89 3, 464–467. doi:10.1038/clpt.2010.279
P‐128: Orientation of a Reactive Mesogen on Photosensitive Surface (2007)

Abstract Reactive mesogens (RMs) are polymerisable liquid crystals that can be formed through the process of in‐Situ photopolymerisation into thin birefringent films. These films have found applications as optical films (retarders) in the flat panel display industry. Application of the birefringent films requires homogeneous orientation of the optical axis over the film's surface. We report high quality fast photoalignment of reactive mesogens on surfaces of cellulose‐cinnamate polymers. Unique photosensitivity of cellulose‐cinnamates and high quality photo‐orientation of reactive mesogenes on these polymers allow cellulose‐cinnamates to be considered as promising materials for producing thin birefringent polymer films by roll‐to‐roll technology.
Synthesis of a Triazatriangulenium Salt (2000)

Die nucleophile aromatische Substitution an 1-BF4 mit Methylamin führte zum extrem stabilen Triazatriangulen-Salz 2-PF6 (siehe Schema). Ein pK-Wert von 23.7 kennzeichnet die thermodynamische Stabilität von 2 und die ausgedehnte Delokalisierung der positiven Ladung. Diese vielseitige Synthese bildet eine allgemeine Methode für die Herstellung heterocyclischer Carbeniumionen.