gebhart/patrepeval huggingface dataset:
High-Frequency Edge Reflection Type Resonators with Excellent Temperature Characteristics (2007)

Currently, some duplexers are required to have a good temperature coefficient of frequency (TCF). An Al electrodes/36–48° YX-LiTaO3 substrate, which is used for most surface acoustic wave (SAW) duplexers, does not have a good TCF. Its TCF can be improved by depositing a SiO2 film with a positive TCF on a transversal SAW filter consisting of a substrate with a negative TCF such as LiTaO3 and LiNbO3. However, resonator-type SAW devices combining a SiO2 film, Al electrodes, and a LiTaO3 substrate do not show good frequency characteristics because of their small reflection coefficient and so on. It is considered as a countermeasure that a resonator using the reflection of a shear horizontal (SH) wave at substrate edges will show good frequency characteristics because its reflection coefficient is very large regardless of the Al electrode and SiO2 films thicknesses. It has been difficult to obtain a high-frequency edge reflection resonator using ordinary machining techniques because it requires extremely fine substrate edges. However, a high-frequency edge reflection resonator with a good TCF and excellent frequency characteristics has been realized using our newly developed method of obtaining fine edges.
Repetitive induction voltage modulator for heavy ion fusion (2002)

Activities of research and development on repetitive induction voltage modulators in the Tokyo Institute of Technology–High Energy Accelerator Research Organization group are presented along with a discussion of the magnetic response of ferro-magnetic materials to fast magnetization and a transient beam loading in the modulators. The modulator is composed of independently driven modules switched by field effect transistors. To make waveform control, the induced voltages are stacked and synthesized in the induction unit. A proof-of-principle experiment shows that the module elements are successfully operated up to megahertz levels with good reproducibility. For the evaluation of magnetic core response, magnetic characteristics are investigated over a wide range of parameters, and an empirical core loss scaling is derived at minor-hysteresis loops. Using the prototype induction module, we have also investigated the effect of beam loading. Results indicate that the effect depends not only on the impedance of the driving circuit but on nonlinearity of the magnetic-core response. This means that the response of the induction modulator depends on the time scale of domain motion and operating point in the B-H plane of magnetic materials. Based on the progress of the component technology in the induction accelerator and database of magnetic materials, a system design has been developed.
Remote desktop. Integrating multiple devices (2009)

Electronic devices have acquired an increasingly important role in our society and are integrated in our lives making both the users and their devices more accessible. Currently in the western world most families have at least one computer. This computer is generally equipped with multimedia accessories and an Internet connection. Portable devices, such as mobile phones and PDAs, are part of this technological and social environment. One might think about using a hands free Bluetooth headset together with a mobile phone, to obtain better sound quality, using a keyboard such as the Handykey Corp. Twiddler in order to dial/type quicker or send SMS messages in an easier way, watching a video on a large computer screen that had previously been downloaded to your mobile phone, etcetera. However, there is a problem when it comes to the interconnectivity between all these devices.
Today users face many difficulties when attempting to use what should be the aggregated possibilities of their devices, rather than simply the functionality of each device. The hypothesis of this project is that the user’s difficulties could be overcome if their devices could be internetworked.
For example, even though mobile phones and PDAs often have a USB interface, unlike typical desktop or laptop computers these devices have been designed to only be USB slaves – hence other USB devices cannot be directly attached to them. There are some signs of this changing with the introduction of USB On-The-Go – but we believe that this is a short-sighted evolutionary step.
The obvious solution is to internetwork these devices. For example, by attaching these various USB devices to a computer that is a USB bus master (host) – we can enable the user to use their USB Twiddler with a USB phone. In this way, a user could remotely access the functions of the set of all of their portable devices – without worrying about how to directly interconnect them in pairs. This could enable new functionality, such as the user being able to answer an incoming call to their cellular phone with the keypad of the Twiddler, while using the audio input and output functions of their Bluetooth headset.
We begin by examining a number of means to establish and use remote connections to access systems remotely. We have focused on the most popular desktop sharing systems, specifically those that use remote desktop protocols. Initially we require manual configuration or use of a discovery protocol to identify the different devices. Later we will examine additional protocols, along with some potentially automatic configuration mechanisms.
A Field Proven System for Selective, Multizone, One-Trip Gravel Packing (1983)

ABSTRACT Newly developed inside casing gravel packing tools have been combined with slurry packing techniques and gravel pack logging to provide a highly successful, field tested, gravel pack system. The system allows multiple, isolated zones to be selectively gravel packed with only one trip in the hole. The one-trip feature of the system not only allows long, multiple zone wells to be completed quickly, but it also reduces and simplifies the number of operations resulting in a more dependable and relatively trouble-free completion method. The paper describes the design and operation of the gravel pack tools and liner assembly, the fluids used in the gravel packing, and the application and interpretation of the gravel pack log. A summary of the experience gained with the system to date is also given.
The Structure of Two Minor Products of the Pyrolysis of Thujone (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Structure of Two Minor Products of the Pyrolysis of ThujoneW. von E. Doering, M. R. Willcott, and M. JonesCite this: J. Am. Chem. Soc. 1962, 84, 7, 1224–1228Publication Date (Print):April 1, 1962Publication History Published online1 May 2002Published inissue 1 April 1962https://pubs.acs.org/doi/10.1021/ja00866a031https://doi.org/10.1021/ja00866a031research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Influence of excess Fe accumulation over the surface of FePt nanoparticles: Structural and magnetic properties (2013)

Herein, we report magnetic properties of as-synthesized face centered cubic (fcc)-FePt nanoparticles (∼5 nm) and its transformed face centered tetragonal (fct) phase when annealed at 600 °C. We observe weak ferromagnetic nature in fcc phase with non-saturating M-H loop indicating the presence of a large fraction of superparamagnetic particles. Excess of Fe-precursor with respect to Pt used in the reaction accumulates on the surface of the FePt nanoparticles and forms a thin layer of Fe-byproduct (Fe3O4) which leads to the formation of FePt/Fe3O4 core/shell structure. This was confirmed by X-ray diffraction, X-ray photoelectron spectroscopy, and microstructural studies. Interestingly due to core/shell formation, the coercivity (Hc) is higher at 300 K than at 50 and 100 K, but there is a steep increase at 5 K. Moreover, hysteresis loop is regular at 300 K whereas it is distorted at 5 K. The reason for temperature dependent Hc anomaly and distortion in M-H loop was examined systematically. The competing exchange interaction seems to be responsible for changes in the magnetic behavior. Besides this, it shows spin glass like behavior much below the blocking temperature which is supposed to be due to existence of two magnetic phases and the exchange coupling between core and shell. This has been confirmed from temperature dependent dc magnetization and ac susceptibility studies. We establish a clear correlation between the magnetization dynamics and the core/shell structure of the nanoparticles. On the other hand, the fct phase shows a very large coercivity with some irregularity in the M-H loop. This irregularity may be ascribed due to segregation of fcc-Fe3Pt (soft) phase on the grain boundaries of fct-FePt (hard). Such inhomogeneity in bimagnetic systems (soft–soft or soft–hard) has strong influence on the nanomagnetism.
Diffusion-limited nonradiative recombination at extended defects in hydride vapor phase epitaxy GaN layers (2011)

Time-resolved free-carrier absorption and transient grating techniques were applied to determine carrier lifetimes and diffusion coefficients in a set of hydride vapor phase epitaxy GaN layers of various thickness (from 10 to 145 μm). A linear increase in nonradiative carrier lifetime in 80–800 K range found to be in a correlation with decrease of the bipolar carrier diffusion coefficient. This correlation confirmed that recombination rate is governed by carrier diffusive flow to the grain boundaries of columnar defects. A model of diffusion-governed nonradiative lifetime was proposed for fitting the measured lifetime values in the layers of different thickness as well as lifetime dependence on temperature or threading dislocation density.
Towards assessment of regional wall stress of the left ventricle using 3D ultrasound imaging (2003)

In order to assess regional left ventricular wall stress in vivo, endocardial surface (SI) and epicardial surface (S2) have been acquired with commercially available 3D ultrasound equipment. Subsequently, SI and S2 have been divided into 16 overlapping areas of interest (AOI). To each of these 16 AOIs an ellipsoid is fitted and the principle radii of this ellipsoid are used to describe the principle radii of the AOI. Wall thickness for each AOI is found by computing the volume between S1 and S2 at each AOI and dividing this by the computed surface of the AOI. Using this algorithm the principal radii and wall thickness have been assessed for an ellipsoid phantom, which both correlated well with the values found for the ideal, mathematically constructed shape.
Generalized Mechanics (1972)

The quantization scheme for generalized Hamiltonians recently proposed by Hayes is shown to be inconsistent. The theory of constraints developed by Dirac is used and leads to a consistent theory.
Effect of ultrasonic degradation of hyaluronic acid extracted from rooster comb on antioxidant and antiglycation activities (2016)

The results demonstrated that the ultrasonic irradiation did not damage and change the chemical structure of HA after degradation; furthermore, decreasing Mw and viscosity of LMWHA after degradation may enhance the antioxidant and antiglycation activity.
CFD Analysis for Merdeka 2 Solar Vehicle (2011)

Vehicle's low drag force is critical to achieve higher speed and for efficient energy usage. Most solar vehicles that participated in the World Solar Challenge event adopted the 'cockroach' shape which has been considered as the best shape to achieve optimum speed and aerodynamics characteristics. However, the team from University of Malaya decided to design their entry vehicle based on the profile of a box fish, said to possess an even lower drag coefficient value. This paper describes the aerodynamics characteristics numerical study of the solar vehicle using a computational fluid dynamics (CFD) code called FLUENT. The numerical computation is based on the frontal area of the vehicle and the obtained results have shown reasonable values of drag and lift coefficients when compared to ordinary road vehicles.
Haploidentical stem cell transplantation in children: Improved engraftment and immune recovery after depletion of T and B cells instead of positive selection of stem cells? (2006)

During the past decade, transplantation of highly purified haploidentical stem cells has become a well established treatment procedure in the cure of many children with malignant and non-malignant diseases. Positive enrichment of peripheral stem cells by anti-CD34 or CD133 magnetic microbeads provides a graft profoundly depleted of T and B cells facilitating engraftment without inducing severe GVHD and EBV-lymphoproliferative disease. Although transplanting "mega doses" (>106/kgBW) of positive enriched stem cells primary graft rejection, delayed immune recovery and thereby an increased risk of transplant related mortality remained major obstacles for the success of this approach. In 27 children with ALL who were transplanted with "mega-doses" (median: 16.46/kgBW; range 5.4–50.4) of positive enriched stem cells from their HLA-haploidentical parents, primary engraftment could be achieved in 88% and after reconditioning in 100% of patients. All patients received G-CSF post transplant and achievedmore than 500 ANC/μl 12 days post transplant (range 8–24). Immune recovery was obtained in all patients with a median time to achieve more than 100 CD3+ and CD4+ cell/μl of 67 and 101.2 days, respectively. Three year EFS of patients transplanted in remission (n = 21) was 0.43 (≥ 0.11). In contrast to positive selection of stem cells, grafts after depletion of CD3/CD19 cells consisted of remarkable amounts of effector cells such as NK-cells (median number: 17.196/kgBW), dendritic cells, precursor T-cells, and monocytes/granulocytes (median number: 446.456/kgBW). These cells are expected to facilitate engraftment, speed up immune reconstitution and provide also anti tumour activity in vivo. So far nine children (ALL, n = 4; AML, n = 2; rhabdomyosarcoma, n = 2 and aplastic anaemia, n = 1) were transplanted with CD3/CD19 depleted peripheral stem cell grafts with a median number of 10.66/kgBW CD 34+ cells (range 4.6–20.0) at the University Children's Hospital Frankfurt. Without G-CSF, all patients (100%) achieved rapid and sustained engraftment with more than 500 ANC/μl and more than 20.000 thrombocytes/μl at day 16.3 and 16.25, respectively. Median time to achieve more than 100 CD3+ and CD4+ cells/μl was 53.0 and 52.5 days. Eight of nine children are alive and well. One child with AML relapsed and died on day 156 post transplant. Conclusions: Haploidentical transplants using CD3/CD19 depleted grafts resulted in better and more reliable engraftment with very rapid and potent immune recovery.
Robust query processing (2011)

In the context of data management, robustness is usually associated with resilience against failure, recovery, redundancy, disaster preparedness, etc. Robust query processing, on the other hand, is about robustness of performance and of scalability. It is more than progress reporting or predictability. A system that fails predictably or obviously performs poorly may be better than an unpredictable one, but it is not robust.
Partitioning and Absolute Flavor Threshold Interactions of Aliphatic and Aromatic Food Packaging Solvents in High‐Fat Cookies (1989)

ABSTRACT Partition coefficients and absolute flavor thresholds were determined in high‐fat containing cookies for 11 organic compounds. They consisted of three structural and functional groups: three homologous aliphatic esters, four aromatic hydrocarbons, and four heterogeneous aliphatics. The two groups of structurally and functionally related compounds exhibited similar individual thresholds but the heterogeneous group gave widely different values. Mixtures of these compounds at subthreshold and threshold concentrations gave interactions that could be sorted into additive or independent categories according to group similarities. Application of numerical categorization formulas did not show consistent correspondence with word definitions of additivity or independence.
Surgical treatment of Focal Epilepsy in childhood with Schizencephaly (2014)

Objective To report three children suffered from focal epilepsy with schizencephaly treated surgically and review the correlative literature.Methods 3 male children were right-handed.the average age was 13.3 years and the epileptic attack was 4.3 years on average.All the children were diagnosed with schizencephaly malformation preoperatively,viz.according to the clinical manifestation,epileptic attack,neuroimaging,EEG,and the assessment of neuropsychology.The epileptogenic lesions were resected through craniotomy.Results Total resection was achieved and the seizure disappeared postoperatively.All the lesions were confirmed as the schizencephaly.Conclusion The epileptic focus of refractory epilepsy in children was originated from schizencephaly,surgery should be seriously considered as an effective method by using minimally invasive technique and cortical-EEG monitoring.

Key words: 
Schizencephaly ;  Fosal Epilepsy;  Subpial resection
Antimicrobial activity of DU-6859, a new potent fluoroquinolone, against clinical isolates (1992)

DU-6859, (-)-7-[(7S)-amino-5-azaspiro(2,4)heptan-5-yl]-8-chloro-6- fluoro-1-[(1R,2R)-cis-2-fluoro-1-cyclopropyl]-1,4-dihydro-4-oxoquinol one-3- carboxylic acid, is a new fluoroquinolone with antibacterial activity which is significantly better than those of currently available quinolones. The MICs for 90% of methicillin-susceptible and -resistant Staphylococcus aureus and Staphylococcus epidermidis clinical isolates (MIC90s) were 0.1, 3.13, 0.1, and 0.39 microgram/ml, respectively. MIC50s of DU-6859 against quinolone-resistant, methicillin-resistant S. aureus were 8-, 32-, 64-, and 128-fold lower than those of tosufloxacin and sparfloxacin, ofloxacin and fleroxacin, ciprofloxacin, and lomefloxacin, respectively. DU-6859 inhibited the growth of all strains of Streptococcus pneumoniae and Streptococcus pyogenes at 0.1 and 0.2 microgram/ml, respectively, and was more active against enterococci than the other quinolones tested. Although the activity of DU-6859 against Pseudomonas aeruginosa was roughly comparable to that of ciprofloxacin at the MIC50 level, it was fourfold more active than ciprofloxacin at the MIC90 level. DU-6859 was also more active against other glucose-nonfermenting bacteria, Haemophilus influenzae, Moraxella catarrhalis, and Neisseria gonorrhoeae, than the other drugs tested. Strains of Bacteroides fragilis and Peptostreptococcus spp. were susceptible to DU-6859; MIC90s were 0.39 and 0.2 microgram/ml, respectively. DU-6859 generally showed activities twofold or greater than those of ciprofloxacin and the other drugs against almost all members of the family Enterobacteriaceae. The action of DU-6859 against the clinical isolates was bactericidal at concentrations near the MICs. DU-6859 activity was not affected by different media, pH, inoculum size, or human serum but was decreased in human urine.
The principle of upper airway unidirectional flow facilitates breathing in humans (2008)

Upper airway unidirectional breathing, nose in and mouth out, is used by panting dogs to facilitate heat removal via water evaporation from the respiratory system. Why some humans instinctively employ the same breathing pattern during respiratory distress is still open to question. We hypothesized that 1) humans unconsciously perform unidirectional breathing because it improves breathing efficiency, 2) such an improvement is achieved by bypassing upper airway dead space, and 3) the magnitude of the improvement is inversely proportional to the tidal volume. Four breathing patterns were performed in random order in 10 healthy volunteers first with normal breathing effort, then with variable tidal volumes: mouth in and mouth out (MMB); nose in and nose out (NNB); nose in and mouth out (NMB); and mouth in and nose out (MNB). We found that unidirectional breathing bypasses anatomical dead space and improves breathing efficiency. At tidal volumes of approximately 380 ml, the functional anatomical dead space during NMB (81 +/- 31 ml) or MNB (101 +/- 20 ml) was significantly lower than that during MMB (148 +/- 15 ml) or NNB (130 +/- 13 ml) (all P < 0.001), and the breathing efficiency obtained with NMB (78 +/- 9%) or MNB (73 +/- 6%) was significantly higher than that with MMB (61 +/- 6%) or NNB (66 +/- 3%) (all P < 0.001). The improvement in breathing efficiency increased as tidal volume decreased. Unidirectional breathing results in a significant reduction in functional anatomical dead space and improvement in breathing efficiency. We suggest this may be the reason that such a breathing pattern is preferred during respiratory distress.
Importance of long non-coding RNAs in the pathogenesis, diagnosis, and treatment of prostate cancer (2023)

Long non-coding RNAs (lncRNAs) are regulatory transcripts with essential roles in the pathogenesis of almost all types of cancers, including prostate cancer. They can act as either oncogenic lncRNAs or tumor suppressor ones in prostate cancer. Small nucleolar RNA host genes are among the mostly assessed oncogenic lncRNAs in this cancer. PCA3 is an example of oncogenic lncRNAs that has been approved as a diagnostic marker in prostate cancer. A number of well-known oncogenic lncRNAs in other cancers such as DANCR, MALAT1, CCAT1, PVT1, TUG1 and NEAT1 have also been shown to act as oncogenes in prostate cancer. On the other hand, LINC00893, LINC01679, MIR22HG, RP1-59D14.5, MAGI2-AS3, NXTAR, FGF14-AS2 and ADAMTS9-AS1 are among lncRNAs that act as tumor suppressors in prostate cancer. LncRNAs can contribute to the pathogenesis of prostate cancer <i>via</i> modulation of androgen receptor (AR) signaling, ubiquitin-proteasome degradation process of AR or other important signaling pathways. The current review summarizes the role of lncRNAs in the evolution of prostate cancer with an especial focus on their importance in design of novel biomarker panels and therapeutic targets.
Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123 (2023)

CD123, the alpha chain of the IL-3 receptor, is an attractive target for acute myeloid leukemia (AML) treatment. However, cytotoxic antibodies or T cell engagers targeting CD123 had insufficient efficacy or safety in clinical trials. We show that expression of CD64, the high-affinity receptor for human IgG, on AML blasts confers resistance to anti-CD123 antibody-dependent cell cytotoxicity (ADCC) in vitro. We engineer a trifunctional natural killer cell engager (NKCE) that targets CD123 on AML blasts and NKp46 and CD16a on NK cells (CD123-NKCE). CD123-NKCE has potent antitumor activity against primary AML blasts regardless of CD64 expression and induces NK cell activation and cytokine secretion only in the presence of AML cells. Its antitumor activity in a mouse CD123<sup>+</sup> tumor model exceeds that of the benchmark ADCC-enhanced antibody. In nonhuman primates, it had prolonged pharmacodynamic effects, depleting CD123<sup>+</sup> cells for more than 10 days with no signs of toxicity and very low inflammatory cytokine induction over a large dose range. These results support clinical development of CD123-NKCE.