gebhart/patrepeval huggingface dataset:
Substrate Specificities of Porcine and Bovine Enteropeptidases toward the Peptide Val-(Asp)4-Lys-Ile-Val-Gly and Its Analogs (2008)

The substrate specificities of porcine and bovine enteropeptidases were investigated using the peptide Val-(Asp)(4)-Lys-Ile-Val-Gly and its various analogs with mutations in the (Asp)(4)-Lys sequence as substrates. The results indicated that in addition to P1 Lys, P2 Asp in the substrates is most important, that P3 Asp is additionally important, and that P5 Asp contributes somewhat to the susceptibility, and that P4 Asp is the least important. These results were essentially identical as between porcine and bovine enteropeptidases.
Increased serum catalytic iron may mediate tissue injury and death in patients with COVID-19 (2021)

The pathophysiology and the factors determining disease severity in COVID-19 are not yet clear, with current data indicating a possible role of altered iron metabolism. Previous studies of iron parameters in COVID-19 are cross-sectional and have not studied catalytic iron, the biologically most active form of iron. The study was done to determine the role of catalytic iron in the adverse outcomes in COVID-19. We enrolled adult patients hospitalized with a clinical diagnosis of COVID-19 and measured serum iron, transferrin saturation, ferritin, hepcidin and serum catalytic iron daily. Primary outcome was a composite of in-hospital mortality, need for mechanical ventilation, and kidney replacement therapy. Associations between longitudinal iron parameter measurements and time-to-event outcomes were examined using a joint model. We enrolled 120 patients (70 males) with median age 50 years. The primary composite outcome was observed in 25 (20.8%) patients-mechanical ventilation was needed in 21 (17.5%) patients and in-hospital mortality occurred in 21 (17.5%) patients. Baseline levels of ferritin and hepcidin were significantly associated with the primary composite outcome. The joint model analysis showed that ferritin levels were significantly associated with primary composite outcome [HR (95% CI) = 2.63 (1.62, 4.24) after adjusting for age and gender]. Both ferritin and serum catalytic iron levels were positively associated with in-hospital mortality [HR (95% CI) = 3.22 (2.05, 5.07) and 1.73 (1.21, 2.47), respectively], after adjusting for age and gender. The study shows an association of ferritin and catalytic iron with adverse outcomes in COVID-19. This suggests new pathophysiologic pathways in this disease, also raising the possibility of considering iron chelation therapy.
Biomechanical Testing of Bioabsorbable Cannulated Screws for Slipped Capital Femoral Epiphysis Fixation (2002)

This study compared cannulated 4.5-mm bioabsorbable screws made of self-reinforced poly-levolactic acid to cannulated 4.5-mm steel and titanium screws for resistance to shear stress and ability to generate compression in a polyurethane foam model of slipped capital femoral epiphysis fixation. The maximum shear stress resisted by the three screw types was similar (self-reinforced poly-levolactic acid 371 +/- 146 MPa, steel 442 +/- 43 MPa, and titanium 470 +/- 91 MPa). The maximum compression generated by both the self-reinforced poly-levolactic acid screw (68.5 +/- 3.3 N) and the steel screw (63.3 +/- 5.9 N) was greater than that for the titanium screw (3 +/- 1.4 N, P <.05). These data suggest cannulated self-reinforced poly-levolactic acid screws can be used in the treatment of slipped capital femoral epiphysis because of their sufficient biomechanical strength.
Wirkungsgeschichte und Aufgaben der Forschung (1961)

Daß Mörikes Werk zu des Dichters Lebzeiten über seine schwäbische Heimat hinaus nur wenig bekannt war, ist eine schon oft mit Bedauern vermerkte Tatsache. Nur ein kleiner Kreis von literarisch Interessierten, von Dichtern und Künstlern nahm von seiner Existenz Notiz. Selbst die wohlwollenden Freunde innerhalb und außerhalb der heimatlichen Grenzen aber waren bei aller aufrichtigen Bewunderung davon überzeugt, daß dieser abseitige Schwabe zwar sehr begabt sei und einen schalkhaften Humor besitze, daß seinem Dichtertum aber verhältnismäßig enge Grenzen gesetzt seien. Märchen und Idylle seien sein eigentliches Feld. Das große Publikum werde ihn kaum je beachten, wenn auch herzlich zu wünschen sei, daß immer eine kleine, vielleicht mit der Zeit sogar wachsende Gemeinde in liebevoller Versunkenheit seiner reinen Dichterstimme lausche. Diese Überzeugung läßt sich sogar aus des befreundeten Friedrich Theodor Vischer schöner und würdiger Grabrede deutlich heraushören.
Supplemental Table 1 from The Epigenomic Landscape of Pituitary Adenomas Reveals Specific Alterations and Differentiates Among Acromegaly, Cushing's Disease and Endocrine-Inactive Subtypes (2023)

&lt;p&gt;Table of clinical parameters for each patient sample.&lt;/p&gt;
RMS delay spread estimation technique using non-coherentchannel measurements (1998)

A method is presented for deriving the RMS delay spread from non-coherent wideband channel measurements (measured amplitude transfer functions). A frequency-domain model of the frequency-selective, Ricean fading channel is used, allowing a theoretical evaluation of the transfer function&apos;s level crossing statistics.
Identification of Functional Fragments in gMYL6 and the Mechanism of Improving NK Cell-Mediated Cytotoxicity. (2020)

Small D peptide could be a novel promising peptide for cancer immunotherapy since it was shown to promote the cytotoxicity of cord blood-derived NK cells.
Glycomycetaceae (2015)

Gly.co.my.ce.ta.ce'a.e. N.L. masc. n. Glycomyces -etis type genus of the family; suff. -aceae ending to denote a family; N.L. fem. pl. n. Glycomycetaceae the Glycomyces family. Actinobacteria / Actinobacteria / Glycomycetales / Glycomycetaceae
Sources of error in intraocular lens power calculation (2008)

Improvement in refractive outcome requires better methods for predicting the postoperative IOL position. Measuring AL by partial coherence interferometry may be of benefit. Autorefraction increases precision in outcome measurement. Reducing these 3 major error sources with means available today reduces the MAE to 0.4 D. Using IOLs that compensate for the spherical aberration of the cornea would eliminate the influence of pupil size. Further improvement would require measuring the asphericity of the anterior surface and radius of the posterior surface of the cornea.
Single-nucleotide polymorphism microarray-based preimplantation genetic diagnosis is likely to improve the clinical outcome for translocation carriers (2013)

The adoption of SNP-PGD combined with TE biopsy and FET may significantly improve the clinical pregnancy rate, and decrease the miscarriage rate after PGD for translocation carriers.
In situ thickness control during plasma deposition of hydrogenated amorphous silicon films by time-resolved microwave conductivity measurements (1995)

Transient photoconductivity measurements have been performed in situ during plasma-enhanced chemical vapor deposition of amorphous hydrogenated silicon by a contactless method that uses the change of the microwave reflection after laser pulse illumination. Through the use of the interference pattern of the amplitude of the transients of microwave reflection during the layer growth, the actual thickness of the amorphous film can be determined. In the case of crystalline silicon substrates, the change in the light absorption in the substrate modified by the growth of the amorphous layer is measured directly. An example of the optimization of antireflective layers on crystalline silicon substrates is shown. A good agreement is found between the experimental data and calculations of optical reflection and transmission on the multilayer structures.
Rythmes neuroendocriniens dans la dépression (1987)

info:eu-repo/semantics/published
Color Reaction Streak Test for Catalase-Positive Microorganisms (1975)

A stable purple color results when a reagent solution is applied to a smear of catalase-positive organisms streaked on a glass slide.
Male Infertility: A Guide for the Clinician (2001)

Anne M Jequier Blackwell Science, £79.50, pp 384, ISBN 0 632 0512 9

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As a result of the rapid development of in vitro fertilisation for treating both male and female infertility, male infertility has become just as important for a consultant gynaecologist assessing an infertile couple as it has for a specialist andrologist. Consequently, the detailed and intricate tests that consultant andrologists developed to identify the cause of …

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Ensuring correct clock timing in ocean bottom node acquisition (2010)

As more ocean bottom node (OBN) surveys are being acquired around the world, more geophysicists become exposed to the intricacies of matching time stamps of instruments' internal clocks to an external clock, a process often referred to as “clock drift correction”. An equivalent process is basically used in all digital data recording and acquisition systems, but is usually hidden from the geophysicist's view. Purpose of this paper is to give a short introduction into the subject, and then argue that for autonomous recordings, a data driven residual time correction is generally needed to achieve the necessary accuracy to solve the geophysical problem at hand. A method is presented that allows a data driven estimation of clock drift. The method is based on picking direct arrival travel times, and requires ∼1% higher shot effort during the acquisition phase of a typical seismic node survey.
Collaborative University Research on Corrosion OSD Education Initiative (2012)

Abstract : This work is in support of a pilot program for the Corrosion Policy and Oversight Office within the Office of the Undersecretary for Acquisition, Technology and Logistics, Corrosion Policy and Oversight. The research and technological investigations within have several objectives. One is to support graduate student research and education in the field of corrosion. This objective is met by the training of graduate students in the Materials Science and Engineering discipline to conduct the research listed and the subsequent placement of a high portion of them in US DoD, national laboratory, governments and industry professional positions. A second objective is the conduct of research studies that will support the implementation of other Corrosion Policy and Oversight Office projects that have been completed or are in progress. A third objective is to plan and conduct targeted studies that within about a 2 year period have a significant probability of delivering products to DoD interested end users that could begin along a path to implementation.
Immunosuppressive effect of prolactin-induced protein: a new insight into its local and systemic role in chronic allergic contact dermatitis (2010)

These findings suggest that PIP might have a local and systemic immunosuppressive effect in mouse chronic ACD.
Exploring the potential for touchless interaction in image-guided interventional radiology (2011)

The growth of image-guided procedures in surgical settings has led to an increased need to interact with digital images under sterile conditions. Traditional touch-based interaction techniques present challenges for managing asepsis in these environments leading to suggestions that new touchless interaction techniques may provide a compelling set of alternatives. In this paper we explore the potential for touchless interaction in image-guided Interventional Radiology (IR) through an ethnographic study. The findings highlight how the distribution of labour and spatial practices of this work are organised with respect to concerns about asepsis and radiation exposure, the physical and cognitive demands of artefact manipulation, patient management, and the construction of "professional vision". We discuss the implications of these key features of the work for touchless interaction technologies within IR and suggest that such issues will be of central importance in considering new input techniques in other medical settings.
Effects of wind direction, wind speed and travel speed on spray deposition (1993)

Abstract Deposition variability from a conventional field sprayer, and effects of wind and travel speed were measured by collecting on small artificial targets in the swath. Whilst deposition on 0.1‐m 2 plots varied by a factor of 3, deposition on single vertical targets typically varied by a factor of 10 and on horizontal targets by a factor of 6. Distinct transversal deposition patterns appeared according to wind direction. The quantity and structure of variability was compared with wind speed and turbulence intensity, but few significant trends were found. Deposition on vertical targets was enhanced by increasing wind speed or increasing travel speed, whilst effects on horizontal targets were inconsistent.
The Structure of Fibrous Proteins of the Collagen-Gelatin Group (1951)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Novel Complex Unbalanced Dicentric X-Autosome Rearrangement in a Thoroughbred Mare with a Mild Effect on the Phenotype (2020)

Complex structural X chromosome abnormalities are rare in humans and animals, and not recurrent. Yet, each case provides a fascinating opportunity to evaluate X chromosome content and functional status in relation to the effect on the phenotype. Here, we report the first equine case of a complex unbalanced X-autosome rearrangement in a healthy but short in stature Thoroughbred mare. Studies of about 200 cells by chromosome banding and FISH revealed an abnormal 2n = 63,X,der(X;16) karyotype with a large dicentric derivative chromosome (der). The der was comprised of normal Xp material, a palindromic duplication of Xq12q21, and a translocation of chromosome 16 to the inverted Xq12q21 segment by the centromere, whereas the distal Xq22q29 was deleted from the der. Microsatellite genotyping determined a paternal origin of the der. While there was no option to experimentally investigate the status of X chromosome inactivation (XCI), the observed mild phenotype of this case suggested the following scenario to retain an almost normal genetic balance: active normal X, inactivated X-portion of the der, but without XCI spreading into the translocated chromosome 16. Cases like this present unique resources to acquire information about species-specific features of X regulation and the role of X-linked genes in development, health, and disease.
Changing Tracks? The Prospect for California Pension Reform (2010)

Though they cover one-tenth of all adult Californians, the state's two largest pension funds face a bleak future, with a combined deficit in the hundreds of billions of dollars. In this paper, we examine the politics and policies behind the state's pension train wreck, identifying two primary causes of the crisis. First, re-election minded officials have systematically underfunded the state's public pensions in an effort to balance the budget. Second, to make up for this underfunding, pension administrators have taken on increasing risk, investing a majority of the systems' assets on corporate stocks. This voter-sanctioned policy shift has exposed the pension funds, and their government sponsors, to increasing stock market volatility, resulting in growing pension payments at precisely the moment that state and local governments can least afford to make them.
The Impact of Intraoperative Gap Difference Between Extension and Flexion on Perception of Joint Function After Total Knee Arthroplasty: a Comparative Retrospective Study (2021)

Abstract Background: The argument presupposes that intra-operative soft tissue balance is associated with patient-reported outcome measures after total knee arthroplasty (TKA). Our aim was to assess the association between the extension-to-flexion gap and patients’ reported perception of knee joint function. Methods: This was a retrospective study of 60 cases of primary cruciate-retaining TKAs performed for the treatment of medial-compartment knee osteoarthritis, at a mean follow-up of 2.6 (range, 2.0–5.2) years. Knee perception was evaluated by asking patients whether they considered their knee joint as “natural” (grade I) or “artificial”, with or without restrictions (grades II–V). The following factors were compared between the two groups: age, sex, and the extension-to-flexion gap difference. A multiple logistic regression analysis was used to identify predictive factors of an artificial knee joint perception. A receiver operating characteristic curve analysis was used to identify cut-off values of predictive factors. Result: Compared to a natural knee joint perception (26 knees, 43%), an artificial perception (34 knees, 57%) was associated with a smaller gap difference at the distraction force of 20 lbf (p &lt; .001), 30 lbf (p = .022), and 40 lbf (p = .038), a lower EuroQol 5-Dimension score (p = .029), and self-reported joint health (Knee injury and Osteoarthritis Outcome Score-Joint Replacement [KOOS-JR], p = .032). A gap difference &lt;1.0 mm was a predictive of an artificial perception (odds ratio, 1.63; 95% confidence interval, 1.33–4.54; p &lt; .001). A cut-off gap difference of 0.99 mm at 20 lbf predicted an artificial perception with a sensitivity of 81.5% and a specificity of 87.9%. Post-operative satisfaction (p &lt; .001), KOOS-JR (p &lt; .001), patient’s joint perception (p = .006), pain (p = .015), and EuroQol 5-Dimension (p = .032) differed between the two groups when the gap difference threshold was set to 1.0 mm. Conclusion: Careful balancing of soft tissue during TKA to achieve an extension-to-flexion gap ≥ 1.0 mm can improve patients’ perception of knee joint function and quality of life.
Complexes Containing Unbridged Dative Metal−Metal Bonds and the Strong Acceptor Ru(CO)3(SiCl3)2 Moiety. Comments on the Transition Metal to Silicon Bond (1998)

Complexes of formula (R3P)(OC)4MRu(CO)3(SiCl3)2 (M = Ru, Os) and (OC)3(ButNC)2MRu(CO)3(SiCl3)2 (M = Fe, Ru, Os) have been prepared from the reaction of cis-Ru(CO)4(SiCl3)2 and the appropriate donor molecule in solution at room temperature. The characterization of the complexes included the crystal structures of (Me3P)(OC)4MRu(CO)3(SiCl3)2 (M = Ru, 1Ru; Os, 1Os) and the three M(CO)3(CNBut)2 derivatives (3Fe, 3Ru, 3Os). All five structures reveal molecules with unbridged metal−metal bonds. The PMe3 ligand is trans to the metal bond in 1M, whereas the isocyanide ligands are cis to this bond in 3M. The ButNC substituents have a cis configuration in 3Fe and 3Ru, but a trans arrangement in 3Os. Complexes 3Fe, 1Ru, and 3Ru are rare examples of structurally characterized compounds in which a first-row or second-row transition metal acts as the donor atom in a molecule containing an unbridged dative bond between two transition metals. The (OC)3(ButNC)2FeRu(CO)3(SiCl3)2 derivative is unstable both in solution and the solid state and attempts to prepare similar complexes in which Fe acts as the donor atom were unsuccessful. In contrast to previous studies, the Ru(CO)4(PR3) derivatives were reasonably stable. The RuSi lengths trans to the dative metal−metal bond (range 2.338(3)−2.357(2) Å) are considerably shorter than the RuSi lengths trans to the carbonyl ligand (range 2.399(5)−2.420(4) Å), whereas there is no significant difference between the SiCl lengths in the two types of SiCl3 ligands in the five structures. These results are interpreted in terms of the trichlorosilyl ligand acting as a π acceptor ligand principally via the Si 3d orbitals.
Contact Stresses in Two Elastic Slabs and a Sandwiched Solid-Metal Flat Gasket (1982)

Contact stresses in two elastic slabs and a sandwiched solid-metal flat gasket are studied to discuss the sealing behabior of the gasket. Assuming that the gasket is an elastic body, the three dimensional theory of elasticity is used to analyse the contact stresses and the deformations in the case where both sides of three laminated plates are compressed axisymmetrically under a local uniform pressure. By neglecting shearing stresses on the contact surfaces, an exact solution satisfying the remaining boundary conditions is obtained. Numerical calculations are carried out for various rigidities and thicknesses of the plates and the loading conditions. In order to investigate the usefulness of the theoretical analysis, the contact stress is measured experimentally by using pressure-sensitive pins attached to a circular plate. It is confirmed that the theoretical results agree well with the experimental ones.
Changes of topsoil under Fagus sylvatica along a small latitudinal-altitudinal gradient (2019)

Abstract This study evaluated soil properties along a small transect in the Apennines chain (central Italy). Using latitude and altitude as surrogates for temperature differences, three locations at different latitudes were selected for the study. At each location, two altitudes were selected (800 and 1000 m). The study was conducted by contrasting chemical and biochemical parameters [microbial biomass-C content, amount of CO2 evolved during basal respiration (ΣCO2–C), and potential enzyme activities] of topsoils (O and A horizons) supporting European beech (Fagus sylvatica L.) forests at different scales of investigation: horizons, altitude, and latitude. Along the topsoil, the trend of all investigated properties was unique to each O and A horizon according to its level of organic matter degradation, availability of substrates, and nutrients. Contrasting the altitudes, the difference of 1 °C of temperature between 800 and 1000 m significantly affected some of the chemical parameters and both microbial and enzyme activities mainly in the mineral horizons, although glucuronidase and phosphodiesterase activities appeared to be mainly controlled by TOC content. Generally, the different enzyme activities were more clearly highlighted when they were expressed per organic C unit, rather than on a soil mass basis. Latitudinal sensitivity was recorded for total N, ΣCO2–C, and some enzyme activities, although no difference in mean annual air temperature occurred along the latitudinal transect. In this case, it is plausible that the summer-winter thermal excursion, which was lower for the southernmost location and increased going north, might have indirectly affected these parameters through changes in the plant-soil relationships, composition of the macro- and mesofauna population, and microbial activity. Considering all the investigated aspects, an increase of 1 °C in mean annual air temperature (in the range 9–10 °C) and/or the alteration of summer-winter thermal excursion might affect the actual soil-plant balance in temperate beech forests, with possible greater mineralization of the topsoil organic matter and a major release of CO2 in the atmosphere.
Variable heavy–variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly (2018)

Technologies for the production of bispecific antibodies need to overcome two major challenges. The first one is correct heavy chain assembly, which was solved by knobs-into-holes technology or charge interactions in the CH3 domains. The second challenge is correct light chain assembly. This can be solved by engineering the Fab-arm interfaces or applying the immunoglobulin domain crossover approach. There are three different crossovers possible, namely Fab-arm, constant domain and variable domain crossovers. The CrossMabCH1-CL exchange does not lead to the formation of unexpected side products, whereas the CrossMabFab and the CrossMabVH-VL formats result in the formation of typical side products. Thus, CrossMabCH1-CL was initially favored for therapeutic antibody development. Here, we report a novel improved CrossMab design principle making use of site-specific positional exchanges of charged amino acid pairs in the constant domain of these CrossMabs to enable the correct light chain assembly in the CrossMabVH-VL and improvements for the CrossMabFab design.