gebhart/patrepeval huggingface dataset:
Quantitative HPLC Analysis of the Level of Fecapentaenes and Their Precursors in Human Feces by a Chemical Conversion Method (1990)

A fast and reliable hplc method for the quantitative analysis of total fecapentaene-12 (FP-12 and its precursors) and total fecapentaene-14 (FP-14 and its precursors) in human feces is described. The analysis is based on the rapid chemical conversion of fecapentaenes and their precursors to more stable methoxytetraenols and the use of synthetic, not naturally occurring, fecapentaene-13 (FP-13) as an internal standard. The synthesis and physical properties of this internal standard are described. The convenience and reproducibility of the method were illustrated by applying the procedure to stool samples obtained from twelve individuals on 3 consecutive days. Levels of total FP's were in the range of 0.1-25.4 micrograms for total FP-12 and 0.1-8.5 micrograms for total FP-14 per g of wet feces. Appreciable fluctuations were observed between levels in samples from the same individual on different days. Reproducibility and recovery were shown to be good.
Analysis of scattering from large planar gratings of compliant cylindrical shells (1977)

A two-dimensional mathematical model for estimating the scattering of plane acoustic waves from an infinite, uniform, plane grating of compliant, elliptically, cylindric shells is developed. Calculations from the model are found to be in good agreement with insertion loss measurements of experimental arrays. The array is shown to be analogous to a multituned acoustic-band rejection filter that has the shell’s fundamental flexural mode in the array for its center frequency. Low-frequency approximations are also included. Conditions for an ultrawide resonance bandwidth having very high array resonance reflectivity are considered and an alternative application for compliant tube gratings, as an acoustic window that provides mechanical shading for a sonar receiving array, is discussed.
Early exercise advances the maturation of glycosaminoglycans and collagen in the extracellular matrix of articular cartilage in the horse (2008)

A measurable effect of the conditioning exercise was demonstrated. The margin between too much and too little work when training foals may be narrower than intuitively presumed.
<title>RF extraction issues in the relativistic klystron amplifiers</title> (1994)

Relativistic klystron amplifiers (RKAs) were successfully operated at NRL in several frequency regimes and power levels. In particular, an L-band RKA was optimized for high- power rf extraction into the atmosphere and an S-band RKA was operated, both in a two-beam and a single-beam configuration. At L-band the rf extraction at maximum power levels (&gt;= 15 GW) was hindered by pulse shortening and poor repeatability. Preliminary investigation showed electron emission in the radiating horn, due to very high voltages associated with the multi-gigawatt rf power levels. This electron current constituted an electric load in parallel with the radiating antenna, and precipitated the rf pulse collapse. At S-band the peak extracted power reached 1.7 GW with power efficiency approximately 50%. However, pulse shortening limited the duration to approximately 50 nanoseconds. The new triaxial RKA promises to solve many of the existing problems.
An Essential Role for Water in an Enzyme Reaction Mechanism:  The Crystal Structure of the Thymidylate Synthase Mutant E58Q, (1996)

A water-mediated hydrogen bond network coordinated by glutamate 60(58) appears to play an important role in the thymidylate synthase (TS) reaction mechanism. We have addressed the role of glutamate 60(58) in the TS reaction by cocrystalizing the Escherichia coli TS mutant E60(58)Q with dUMP and the cofactor analog CB3717 and have determined the X-ray crystal structure to 2.5 A resolution with a final R factor of 15.2% (Rfree = 24.0%). Using difference Fourier analysis, we analyzed directly the changes that occur between wild-type and mutant structures. The structure of the mutant enzyme suggests that E60(58) is not required to properly position the ligands in the active site and that the coordinated hydrogen bond network has been disrupted in the mutant, providing an atomic resolution explanation for the impairment of the TS reaction by the E60(58)Q mutant and confirming the proposal that E60(58) coordinates this conserved hydrogen bond network. The structure also provides insight into the role of specific waters in the active site which have been suggested to be important in the TS reaction. Finally, the structure shows a unique conformation for the cofactor analog, CB3717, which has implications for structure-based drug design and sheds light on the controversy surrounding the previously observed enzymatic nonidentity between the chemically identical monomers of the TS dimer.
Luminescent Assay for the Screening of SARS‐CoV‐2 MPro Inhibitors (2022)

Since the outbreak of SARS-CoV-2 in December 2019 millions of infections have been reported globally. The viral chymotrypsin-like main protease (M<sup>Pro</sup> ) exhibits a crucial role in viral replication and represents a relevant target for antiviral drug development. In order to screen potential M<sup>Pro</sup> inhibitors we developed a luminescent assay using a peptide based probe containing a cleavage site specific for M<sup>Pro</sup> . This assay was validated showing IC<sub>50</sub> values similar to those reported in the literature for known M<sup>Pro</sup> inhibitors and can be used to screen new inhibitors.
Non-Solid Explosives for Shaped Charges. Part II. Target Penetration with Metal Liner Devices Using Sensitized Nitromethane Liquid Explosive (2009)

In an attempt to overcome the inconsistencies of plastic explosive–filled shape charges in EOD operations we have explored the use of sensitized gelled nitromethane liquid as a filling for a number of shaped charge devices. The ability to penetrate munition casings and induce deflagration is not only dependent on the velocity of detonation of the mixture, investigated in previous papers, but also on the geometry of the devices used and in some cases the confinement present in the device. In this article a range of nitromethane-based explosive fillings, with a range of velocities of detonation, was used to investigate the performance, in terms of target penetration, of both conical and dished metal liners and flat-bottomed cup liners mounted in cylindrical tubes. A number of unexpected results were obtained when copper dish devices were mounted in metal tubes and demonstrated a penetration dependence on standoff to the target. These observations were confirmed by flash X-ray investigation of the functioning devices. Some discussion of the critical parameters controlling the liner behavior has been undertaken.
An exploratory study of a touch-based gestural interface for elderly (2010)

This paper presents the design ideas and a preliminary study of a touch-based gestural interface to support older adults in social networking. We had the hypothesis that the directness of gestures made them well suited to implement an interaction metaphor based on familiarity. Although preliminary, this hypothesis can be sustained. In particular, we found that most of the gestures (and in particular the iconic and the dynamic ones) have a hedonic quality that attracted and motivated our participants. We think that our results may contribute to the ongoing debate about gestural interfaces and help in understanding the value and the issue of this form of interaction.
Nanoliter Droplet Characterization using Vibrating Crystal Sensor with Surface-attached Polymer Hydrogel Coating (2012)

This paper presents a novel method for nanoliter droplet characterization using a polymer coated sensor of a low-cost quartz crystal microbalance (QCM). The gold electrode of the crystal sensor was coated by a surface-attached polymer hydrogel film of about 2 μm thickness using simple spin casting and photocrosslinking procedure [1], [2]. The resonance frequency of the coated crystal sensor was continuously recorded at the sample rate of 2 Hz over 90 seconds before and after loading a micro droplet of filtered double-distilled water. Good repeatability (max. CV = 3.8%) and good linearity (r(x,y)= 0.995) of the maximum resonance frequency shift have been observed during 144 dispenses for 6 different droplet volumes in the range from 3 nl to 13 nl. A calibration line for the measured domain of the maximum frequency shift in relation to droplet mass was established according to the gravimetric calibration of the used dispenser with an ultra-microbalance.
New insights into metabolic pathway optimization by analogy with industrial manufacturing processes (1999)

Conference Article| February 01 1999 New insights into metabolic pathway optimization by analogy with industrial manufacturing processes F. Ortega; F. Ortega *Universitat de Barcelona, Department de Bioquímica i Biologia Molecular, Facultat de Química, 08028 Barcelona, Catalunya, Spain Search for other works by this author on: This Site PubMed Google Scholar E. Martí; E. Martí †lndustrias Metálicas Castelló, c/Potosí 23, 08030 Barcelona, Catalunya, Spain Search for other works by this author on: This Site PubMed Google Scholar M. Cascante M. Cascante 1 *Universitat de Barcelona, Department de Bioquímica i Biologia Molecular, Facultat de Química, 08028 Barcelona, Catalunya, Spain 1To whom correspondence should be addressed Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1999) 27 (2): 276–281. https://doi.org/10.1042/bst0270276 Article history Received: July 31 1998 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation F. Ortega, E. Martí, M. Cascante; New insights into metabolic pathway optimization by analogy with industrial manufacturing processes. Biochem Soc Trans 1 February 1999; 27 (2): 276–281. doi: https://doi.org/10.1042/bst0270276 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: J, metabolic flux, τ, transit time, productivity performance index, σ, concentration of intermediates within the system, q, equilibrium constant This content is only available as a PDF. © 1999 Biochemical Society1999 Article PDF first page preview Close Modal You do not currently have access to this content.
Hypersonic vehicle trajectory optimization (1981)

The purpose of this task is to assemble a computer code for solving the maximum crossrange and maximum plane change problems for hypersonic vehicles. These problems are formulated as parameter optimization or nonlinear programming problems by replacing each control function by a number of nodal points and linear interpolation. An existing code for solving the nonlinear programming problem with the augmented-Lagrangian method is used to perform the optimization. Derivatives are calculated numerically by central differences. The code works well in that both trajectory optimization problems are solved successfully. By changing that part of the code which defines the problem, this code can be used to solve any trajectory optimization problem.
A New Fatigue Life Model for Rolling Bearings (1985)

This paper describes a novel model for the prediction of fatigue life in rolling bearings. Central to this model is the postulation of a statistical relationship between the probability of survival, the fatigue life, and a stress-related fatigue criterion level above a fatigue limit for an elementary volume of material in the bearing. Using this concept, the stress volume to fatigue and the fatigue life of the bearing can be calculated for different loads, material and operating conditions. Comparisons between experimentally obtained rolling bearing fatigue lives and lives predicted using this theory indicate its ability to account for phenomena hitherto excluded from fatigue life predictions. Furthermore, comparisons between experimentally obtained fatigue lives for other specimens used in structural fatigue tests and fatigue lives predicted using the new model show good agreement.
Nitrovasodilator-induced inhibition of LTB4 release from human PMN may be mediated by cyclic GMP. (1990)

This study investigates the action of nitrovasodilators on f-metleu-phe (FMLP)-stimulated LTB4 release and intracellular cyclic nucleotide levels in human polymorphonuclear leukocytes (PMN). Sodium nitroprusside, and the molsidomine (MOL) metabolites SIN-1 and SIN-1A potently inhibited LTB4 release and increased cGMP levels. No significant effects on LTB4 release or cGMP accumulation were observed in the presence of molsidomine or glyceryl trinitrate. None of the compounds tested affected cAMP levels. It is suggested that nitrovasodilators (i) inhibit LTB4 release from human PMN via enhanced cGMP and (ii) that this inhibition requires the presence of an active metabolite, probably nitric oxide.
Improvement Of Image Resolution Beyond Classical Limit By Phase-Sensitive Optical Parametric Amplifier (2011)

When an optical parametric amplifier (OPA) operated as a phase-sensitive amplifier (PSA) is used for point source imaging, the angular resolution improvement can defeat the classical Rayleigh limit, and approach the de Broglie resolution.
Field Efficacy of an Attenuated Infectious Bronchitis Variant 2 Virus Vaccine in Commercial Broiler Chickens (2018)

Egyptian poultry suffer from frequent respiratory disease outbreaks associated with Infectious Bronchitis Virus (IBV) variant 2 strains (Egy/VarII). Different vaccination programs using imported vaccines have failed to protect the flocks from field challenge. Recent studies confirmed a successful protection using homologous strains as live attenuated vaccines. In this study, a newly developed live attenuated IB-VAR2 vaccine representing the GI-23 Middle East IBV lineage was evaluated in day-old commercial broilers in an IBV-endemic area. A commercial broiler flock was vaccinated with the IB-VAR2 vaccine at day-old age followed by IB-H120 at day 16. The vaccinated flock was monitored on a weekly basis till the slaughter age. The health status and growth performance were monitored, and selected viral pathogen real-time RT-PCR (rRT-PCR) detection was conducted on a weekly basis. Finally, the flock was compared to a nearby farm with only the classical IB-H120 vaccination program. Results showed that the IB-VAR2 vaccine was tolerable in day-old broiler chicks. The IBV virus rRT-PCR detection was limited to the trachea as compared to its nephropathogenic parent virus. Respiratory disease problems and high mortalities were reported in the IB-H120-only vaccinated flock. An exposure to a wild-type Egy/VarII strain was confirmed in both flocks as indicated by partial IBV S1 gene sequence. Even though the IB-VAR2-vaccinated flock performance was better than the flock that received only IB-H120, the IBV ELISA (enzyme-linked immunosorbent assay) and log2 Haemagglutination inhibition (HI) antibody mean titers remained high (3128 ± 2713 and &ge;9 log2, respectively) until the 28th day of age. The current study demonstrates the safety and effectiveness of IB-VAR2 as a live attenuated vaccine in day-old commercial broilers. Also, the combination of IB-VAR2 and classical IBV vaccines confers a broader protective immune response against IBV in endemic areas.
Measurement of endotracheal tube secretions volume by micro computed tomography (MicroCT) scan: an experimental and clinical study (2014)

MicroCT appears as a feasible and precise technique to measure volume of secretions within ETTs after extubation. In patients, secretions tend to accumulate in the cuff region, with high variability among patients.
A Method for Citizen Scientists to Catalogue Worldwide Chlorociboria spp. Distribution (2018)

The blue-green pigment known as xylindein that is produced by species in the Chlorociboria genus is under heavy investigation for its potential in textile dyes, wood dyes, and solar cells. Xylindein has not yet been synthesized, and while its production can be stimulated under laboratory conditions, it is also plentiful in downed, decayed wood in forested lands. Unfortunately, little is known about the wood preference and forest type preference for this genus, especially outside New Zealand. To map the genus would be a massive undertaking, and herein a method by which citizen scientists could contribute to the distribution map of Chlorociboria species is proposed. The initial trial of this method found untrained participants successfully identified Chlorociboria stained wood in each instance, regardless of forest type. This simple, easy identification and classification system should be well received by citizen-scientists and is the first step towards a global understanding of how xylindein production might be managed for across various ecosystems.
Low-resistance nonalloyed ohmic contacts to Si-doped molecular beam epitaxial GaAs (1985)

We have found evidence that the surface depletion charge density in molecular beam epitaxial n-GaAs doped heavily with Si approaches the Si concentration. In situ metallization of the as-grown surface of GaAs uniformly doped with Si at 1×1020 cm−3 yields a specific contact resistivity of 1.3 μΩ cm2, indicating a space-charge density about equal to the silicon density despite a measured bulk electron density of 4×1018 cm−3. This contact resistivity is among the lowest for nonalloyed ohmic contacts to n-GaAs. We attribute the large discrepancy between surface space-charge density and bulk electron density to the amphoteric behavior of silicon in GaAs. Surface Fermi-level pinning and arsenic stabilization create a surface depletion region where donor site selection predominates, whereas the extrinsic electron density in the bulk causes self-compensation.
Degradable Mg scaffolds produced by selective laser melting (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Titanium(0) Reagents; 1. A Facile Deoxygenation of Unfunctionalized AromaticN-Oxides (1987)

The application of titanium(0) slurry in deoxygenation of unfunctionalized aromatic N-oxides under mild conditions is reported. In general only parent heterocycles were formed in high yields.
Practical considerations for the demonstration of a single walled carbon nanotube actuator (2001)

The conversion of electrical energy into mechanical energy using macro scale sheets of carbon nanotubes (bucky paper) has been shown to exhibit comparable or superior performance to that of human skeletal muscle. This level of performance was not as high as predicted by theoretical calculations. Therefore, working from a bottom-up principle, it is of paramount interest to not only demonstrate a single carbon nanotube actuator, but to gain a better understanding of the process of nanotube actuation. In this paper, practical considerations and approaches to the preparation of suspended single walled carbon nanotube (SWNT) structures and the measurement of actuation force are discussed.
Molecular Descriptors for Chemoinformatics (2009)

Volume I: ALPHABETICAL LISTING Introduction Historical Perspective QSAR/QSPR Modeling How to Learn From This Book Users Guide Notations and Symbols Alphabetical Listing of approx. 3300 entries Greek Alphabet Entries Numerical Entries Volume II: APPENDICES, REFERENCES Full bibliography of more than 6000 references, selected from 450 journals and covering the period from the beginning of molecular descriptor research until the year 2008 Greek alphabets Acronyms Molecular structures
Wideband optical logic gates based on a 3×3 multi-mode interference coupler (2017)

In this paper, an all-optical logic gate with multiple functions and asymmetric structure is theoretically designed and simulated using a silicon on insulator (SOI)-based multimode interference (MMI) coupler. By switching the optical signal to different input waveguide ports, the device can function as an OR, NOT, NAND, or NOR gate simultaneously or individually. Simulation results by using three-dimensional beam propagation method (3D-BPM) incorporated with effective index method (EIM) show that these logic gates can operate with low loss in a wide wavelength band as much as 100 nm. It is a kind of promising device for applications on the next-generation high-speed, compact logic circuits, ultrafast signal processing as well as future silicon photonics-based integrated circuits.
Ruthenium complexes of a bipyridyl(pyridyl)methane ligand : Effect of substituents at the methylene group on structure and photophysics (2005)

In the Porsolt swimming test intact rats acquire and retain the immobile response indistinguishably at 25 and 30 degrees C; at both temperatures retention is abolished by administration of the glucocorticoid antagonist RU38486 and the kappa-selective opiate receptor antagonist MR2266 when given together, but not when either is given alone. At 20 degrees C, however, the animals do not acquire the response, and have levels of retention significantly lower than at the higher temperature. This deficit is not restored by administration of glucocorticoids, kappa-opioid receptor-selective agonists, thyroid hormone or glucose.
[Our physiotherapy treatment of articular fractures of the mandibular condyle]. (2003)

Physical therapy greatly contributes to improved function of the injured temporomandibular joint, particularly after trauma. In our unit, we use the Delaire rehabilitation method for patients presenting a fracture of the mandibular condyles. This method involves active mobilization, first with assistance, then with facilitation, and finally against resistance. A rehabilitation session starts with a preparation of the teguments and muscles associated with relaxation exercises. The joint is first mobilized by assisted movements if needed. When unassisted motion becomes possible, propulsion, diduction and open-close exercises are then performed with neuromuscular facilitation. When sufficient amplitudes have been achieved, the program proceeds with opposed exercises. By inducing propulsion and diduction (lateral pterygoid muscle) movements, physical therapy stimulates regeneration of the condylar unit, thus facilitating optimal functional rehabilitation. Posture and passive motion methods, which in our opinion are poorly adapted to the temporomandibular joint, are used little in our unit. Since condylar regeneration is controlled by functional factors, the lateral pterygoid muscle is an important element. Good functional outcome, and the absence of ankylosis, depends directly on the quality of active rehabilitation.
Study on a very low bit-rate video coding algorithm (1993)

A very low bit-rate video coding algorithm is proposed. The algorithm is a hybrid motion compensation andDCT (discrete cosine transform) coding. However a progressive transmission scheme with a frequency-orientedcoding of DCT coefficients is proposed to cope with partia.1 freeze due to the buffer overflow. In addition, somemethods to improve motion estimation are proposed. The simulation results show the proposed algorithm showsperceptually better decoded images than the traditional RM8 (reference model 8) algorithm.