gebhart/patrepeval huggingface dataset:
tLivin Displays Flexibility by Promoting Alternative Cell Death Mechanisms (2014)

Livin is a member of the Inhibitor of Apoptosis (IAP) protein family that inhibits apoptosis triggered by a variety of stimuli. We previously demonstrated that while Livin inhibits caspase activity, caspases can cleave Livin to produce a truncated protein, tLivin and that this newly formed tLivin paradoxically induces cell death. However to date, the mechanism of tLivin-induced cell death is not fully understood. In this study, we set out to characterize the form of cell death mediated by tLivin. Here we demonstrate that, unlike most death-promoting proteins, tLivin is a flexible inducer of cell death capable of promoting necrosis or apoptosis in different cell lines. The unusual flexibility of tLivin is displayed by its ability to activate an alternative form of cell death when apoptosis is inhibited. Thus, tLivin can promote more than one form of cell death in the same cell type. Interestingly, in cells where tLivin induces necrosis, deletion of the caspase binding BIR domain results in tLivin-induced apoptosis, suggesting the BIR domain can potentially hamper the ability of tLivin to induce apoptosis. We further elucidate that tLivin activates the JNK pathway and both tLivin-induced apoptosis and necrosis are partially mediated by JNK activity. Acquired resistance to apoptosis, common in many tumors, impinges on the efficiency of conventional anti-cancer agents that function primarily by inducing apoptosis. The ability of tLivin to induce death of apoptosis-compromised cells makes it an attractive candidate for targeted cancer therapy.
Structural and magnetic studies of heteromagnetic multilayers by reflectivity of circularly polarized soft x rays (abstract) (1996)

The reflectivity of circularly polarized (CP) soft x rays is a technique which combines the power of x-ray scattering and magnetic circular dichroism and allows the structural and magnetic characterization of heteromagnetic multilayers. In this technique, the energy and angular dependence of the differential reflectivity of left- and right-circularly polarized soft x rays at the relevant absorption edges of the constituent elements of the multilayers are measured. As examples the reflectivity curves for single films of Fe, Co, ordered and disordered Fe50Co50 alloys, and for a trilayer consisting of two single crystal Fe30Co70 films separated by an 8.7 Å Mn spacer layer media utilizing complex dielectric tensors with no free parameters show that the rich reflectivity curves can be used to determine the multilayer magnetic ordering, film thicknesses, interface quality, as well as differentiating between ordered and disordered alloys.
Polyaniline Langmuir–Blodgett films: formation and properties (2009)

The deposition and characterisation of Langmuir-Blodgett (LB) layers of polyaniline (PAN) on solid supports is described. Langmuir films were spread as a mixture of PAN and dodecylbenzenesulfonic acid (DBSA) at the water/air interface and deposited on either glass or indium tin oxide (ITO). Mono- and multi-layer films of PAN/DBSA were characterized by X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), absorption spectroscopy and cyclic voltammetry (CV). The ultrathin films produced were found to be highly uniform and very stable. Further characterisation of the films was accomplished by scanning electrochemical microscopy (SECM) in the feedback mode. It was found that the conductivity depended strongly on the pH of the solution and the number of layers deposited. Values for the pH-dependent lateral conductivity of PAN LB films are reported.
Thiol-Containing Degradable Poly(thiourethane-urethane)s for Tissue Engineering (2010)

Poly(thiourethane-urethane)s with varying amounts of sulphur were synthesised by a two-step polycondensation consisting of the sequential addition of 1,6-hexamethylene diisocyanate and bis(2-mercaptoethyl) ether in a poly(epsilon-caprolactone) diol solution. Polymers prepared had high weight-average molecular weight and typical microdomains separation, as shown by size-exclusion chromatography and thermal analysis. Polymer surfaces were characterized by X-ray photoelectron spectroscopy and atomic force microscopy. The quantification of thiol groups at the surface was assessed using a fluorescent assay. Thiol concentration ranged between 7 and 14 nmol/cm, and was directly related to the amount of sulphur introduced in the polymerization and the macromolecule chains orientation at the surfaces. A preliminary in vitro degradation study and a proliferation assay were performed. The poly(thiourethane-urethane)s may have important applications as biodegradable and biocompatible materials for cartilage and bone tissue engineering. The surface thiol groups add the prospect of further functionalization. This is an important benefit compared to biodegradable poly(urethane)s that usually present low biological activity.
Full fault dictionary storage based on labeled tree encoding (2002)

The process of fault dictionary compaction can lead to a loss of information that is potentially useful in locating unmodeled failures. The focus of this paper is on developing alternative storage structures that can efficiently represent full fault dictionaries without discarding any information. We present the problem of storing the full fault dictionary storage as a labeled tree encoding problem. Two labeled trees are introduced to represent the diagnostic experiment. For the first tree, the unlabeled tree is stored using a binary string code, while the second tree is constructed so that the unlabeled tree is regular in structure, thus allowing implicit storage. Eight alternative representations based on the three label components are presented and two existing full fault dictionary representations (the matrix and the list dictionaries) are shown to be special cases in our general framework. Experimental results on the ISCAS 85 and ISCAS 89 circuits are used to study and characterize the performance of the proposed storage structures.
P4–190: Transcranial Doppler cerebral blood flow velocity and cognitive function: Results from the Einstein Aging Study (EAS) (2013)

Reduced cerebrovascular perfusion has been associated with cognitive decline and dementia. However there are few data regarding the relation of cerebrovascular perfusion to domains of cognitive performance in non-demented population based samples due in part to feasibility issues and cost of P.E.T. or MRI. Transcranial Doppler (TCD) ultrasound provides an inexpensive, rapid, non-invasive technique for assessing cerebrovascular function. We examined the cross-sectional associations of TCD measures of blood flow velocities in arteries of the circle of Willis to cognitive performance in participants in the EAS cohort. Analyses included 97 non-demented, community residing elderly, age 3 70. TCD was performed by a trained ultrasound technician using a standardized and validated research protocol during the annual clinic visit which included neuropsychological testing and neurological exams. The group was 52% female, mean age 80.9 (±5.6) years, mean education 15 years. Cognitive domain evaluation included episodic memory (Free Recall from Free and Cued Selective Reminding Test-FR-FCSRT and WMS-R Logical Memory I subtest -LM), semantic memory (category fluency CF), executive function (WAIS-III digit symbol substitution test-DSST; Trail-Making Test-B TMT-B), and language (phonemic fluency-FAS). We computed the mean of right and left flow velocities (MFV) for each vessel. Spearman's correlation coefficients were used to examine the relation of MFV in the anterior (ACA_MFV), posterior (PCA_MFV) and middle (MCA_MFV) cerebral arteries to cognitive performance. Linear regression analyses were used to determine whether associations persisted after adjustment for age, sex and education. There was a consistent pattern showing a positive correlation between CF, DSST, TMT-B and FAS with ACA_MFV and PCA_MFV while memory tests were not correlated with MFV. The MCA-MFV was not correlated with any cognitive measures. The associations of ACA_MFV and PCA_MFV with cognition remained after adjustment for age sex, and education. Cerebral blood flow appears to be more highly correlated with performance on tests of executive function and language than with tests of episodic memory. This is consistent with prior information suggesting a link between vascular processes and frontal executive function. TCD may be useful for distinguishing persons at risk for amnestic versus non-amnestic mild cognitive impairment. Longitudinal data are needed to confirm this hypothesis.
BRCA1 and BRCA2 mutations in Japanese patients with ovarian, fallopian tube, and primary peritoneal cancer (2015)

In this unselected Japanese population, approximately 13% of the cases with ovarian cancer appeared to be associated with an inherited risk, regardless of a family history. This finding indicates that BRCA1/2 genetic testing should be performed for all patients with ovarian cancers.
Influence of lipid shell physicochemical properties on ultrasound-induced microbubble destruction (2005)

We present the first study of the effects of monolayer shell physicochemical properties on the destruction of lipid-coated microbubbles during insonification with single, one-cycle pulses at 2.25 MHz and low-duty cycles. Shell cohesiveness was changed by varying phospholipid and emulsifier composition, and shell microstructure was controlled by postproduction processing. Individual microbubbles with initial resting diameters between 1 and 10 microm were isolated and recorded during pulsing with bright-field and fluorescence video microscopy. Microbubble destruction occurred through two modes: acoustic dissolution at 400 and 600 kPa and fragmentation at 800 kPa peak negative pressure. Lipid composition significantly impacted the acoustic dissolution rate, fragmentation propensity, and mechanism of excess lipid shedding. Less cohesive shells resulted in micron-scale or smaller particles of excess lipid material that shed either spontaneously or on the next pulse. Conversely, more cohesive shells resulted in the buildup of shell-associated lipid strands and globular aggregates of several microns in size; the latter showed a significant increase in total shell surface area and lability. Lipid-coated microbubbles were observed to reach a stable size over many pulses at intermediate acoustic pressures. Observations of shell microstructure between pulses allowed interpretation of the state of the shell during oscillation. We briefly discuss the implications of these results for therapeutic and diagnostic applications involving lipid-coated microbubbles as ultrasound contrast agents and drug/gene delivery vehicles.
Ultrasound biomicroscopic study of sclelotomy sites after implantation of sustained release drug devices (2002)

UBM is helpful in detecting abnormal manifestations around ganciclovir implants and is a valuable tool to assess the changes of the sclerotomy sites of the sustained released intraocular devices.
Fluid saturation and pressure prediction in a multi‐component reservoir by combined seismic and electromagnetic imaging (2002)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2002Fluid saturation and pressure prediction in a multi‐component reservoir by combined seismic and electromagnetic imagingAuthors: G. Michael HoverstenRoland GrittoJohn WashbourneTom DailyG. Michael HoverstenLawrence Berkeley National Laboratory, Roland GrittoLawrence Berkeley National Laboratory, John WashbourneTomoSeis Inc., and Tom DailyLawrence Berkeley National Laboratoryhttps://doi.org/10.1190/1.1817024 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1817024FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 2002ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2002 Pages: 2478 publication data© 2002 Copyright © 2002 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 03 Jan 2005 CITATION INFORMATION G. Michael Hoversten, Roland Gritto, John Washbourne, and Tom Daily, (2002), "Fluid saturation and pressure prediction in a multi‐component reservoir by combined seismic and electromagnetic imaging," SEG Technical Program Expanded Abstracts : 1770-1773. https://doi.org/10.1190/1.1817024 Plain-Language Summary PDF DownloadLoading ...
Vectorially combined distributed power amplifier with load pull impedance determination (2010)

A new topology for a distributed power amplifier (DPA) is presented to maximise DC-RF conversion (i.e. for high output power). The topology is featured by vectorially combined current sources when loading power transistors into distributed output and input networks using impedance termination values gathered by device load pull. To the authors&apos; knowledge, the output power achieved in this work is the best for DPAs within the frequency range up to 2 GHz.
Dynamic Scalable Software Downloads for Mobile Terminal Mass-upgrades (2007)

This paper investigates various solutions to improve the scalability of software downloads for mobile terminal mass-upgrades. We look at procedures to improve transport- and network-layer performance by reacting on-the-fly to the dynamics of such downloads. Assisting the network layer, we present further work on dynamic adaptation of the one-to-many download method, particularly concentrating on the transport-layer implications of dynamic switching between many-unicast and reliable multicast. Specifically at the transport layer, we investigate the dynamic adaptation of reliable multicast characteristics for mass-upgrade downloads. Based on the unique heterogeneity in end-to-end performance characteristics of different source-receiver paths to mobile terminals, we argue the validity and usefulness of the solutions presented.
GeoLife: Managing and Understanding Your Past Life over Maps (2008)

The increasing popularity of GPS device has boosted many applications where more and more GPS logs have been accumulating continuously. Managing and understanding the collected GPS data are two important issues for these applications. On one hand, by indexing the increasing GPS data, we can provide effective retrieval method for users to find the corresponding GPS data interests them. On the other hand, by understanding user's GPS data, we are more likely to enable novel services which would stimulate people's passion on contributing GPS data in turn. However, so far, GPS data are still used directly without much understanding. In our project, referred to as GeoLife, we focus on visualization, organization, fast retrieval, and effective understanding of GPS track logs for both personal and public use. It not only provides a powerful platform for people to effectively manage their GPS data but also help them well understand a person's past experience from GPS data.
A degenerate four-wave mixing spectroscopy device based on two dimensional pulse shaping (2004)

Degenerate, noncollinear, optically heterodyned, spectrally resolved, multidimensional femtosecond Χ(3) measurements are executed with waveforms, delays, and phases of all fields controlled by a single active device. Extension to higher-order and IR spectroscopies is possible.
Health-related quality of life in patients with locally advanced or metastatic breast cancer treated with eribulin mesylate or capecitabine in an open-label randomized phase 3 trial (2015)

The clinical benefit of eribulin versus capecitabine was evaluated using health-related quality of life (HRQoL) data from a phase 3 randomized trial in patients with pretreated advanced/metastatic breast cancer (ClinicalTrials.gov identifier: NCT00337103). The study population has been described previously (Kaufman et al. in J Clin Oncol 33:594-601, 2015). Eligible patients received eribulin (1.4 mg/m(2) intravenously on days 1 and 8) or capecitabine (1.25 g/m(2) orally twice daily on days 1-14) per 21-day cycles. HRQoL was assessed using the European Organisation for Research and Treatment of Cancer (EORTC) Quality-of-life Questionnaire-Core 30 questions (QLQ-C30) and breast module-23 questions (QLQ-BR23), administered at baseline through 24 months, until disease progression or other antitumor treatment initiation. Minimally important difference (MID) and time to symptom worsening (TSW) were investigated. 1062 (96.4 %) Patients completed the EORTC questionnaire at baseline; overall, compliance was ≥80 %. Patients receiving capecitabine versus eribulin had significantly worse symptoms (higher scores) for nausea/vomiting (MID 8; P < 0.05) and diarrhea (MID 7; P < 0.05). Treatment with eribulin versus capecitabine, led to worse systemic therapy side-effects (dry mouth, different tastes, irritated eyes, feeling ill, hot flushes, headaches, and hair loss; MID 10; P < 0.01). Clinically meaningful worsening was observed for future perspective (MID 10; P < 0.05) with capecitabine and for systemic therapy side-effects scale (MID 10; P < 0.01) with eribulin. Patients receiving capecitabine experienced more-rapid deterioration in body image (by 2.9 months) and future perspective (by 1.4 months; P < 0.05) compared with those on eribulin; the opposite was observed for systemic side-effects where patients receiving eribulin experienced more-rapid deterioration than those receiving capecitabine (by 2 months; P < 0.05). Eribulin and capecitabine were found to have similar impact on patient functioning with no overall difference in HRQoL. Patients receiving eribulin reported worse systemic side-effects of chemotherapy but reduced gastrointestinal toxicity compared with capecitabine.
The matrix converter drive performance under abnormal input voltage conditions (2002)

The matrix converter is a direct frequency conversion device with high input power quality and regeneration capability. As a device without energy storage elements, it has higher power density than PWM inverter drives. However, for the same reason, the AC line side disturbances can degrade its performance and reliability. In this paper, the behavior of the matrix converter drive under abnormal input line voltage conditions has been investigated. A technique to eliminate the input current distortion due to the input voltage unbalance has been developed and its feasibility proven via computer simulations and laboratory experiments. The power line failure behavior has also been investigated and the rapid re-starting capability of the matrix converter drive has been demonstrated via laboratory experiments.
Double distortion correction method in a catadioptric vision system with a conic mirror (2017)

Because of the low calibration precision caused by reflector distortion in catadioptric vision systems with conic mirrors, we proposed a double distortion correction model based on the panoramic image rectification. The lens distortion and the reflector distortion are analyzed independently in the mathematic model of the double distortion correction. Moreover, the modified model in this paper added the trigonometric functions into the polynomial model to solve the combined distortion. Additionally, extensive experiments, both simulative and real data, have been carried out and show that the proposed model achieves comparable measurement accuracy in contrast with the traditional distortion method.
Distributed Energy Management of the Hybrid AC/DC Microgrid with High Penetration of Distributed Energy Resources Based on ADMM (2021)

This paper aims to investigate energy management of the hybrid AC/DC microgrid with the high penetration of distributed energy resources (DERs), such as electrical vehicles, heat pumps, and photovoltaics. In the previous studies, energy management of the hybrid microgrid is usually carried out by the system operator in a centralized manner, which suffers from the compromise of privacy information protection and the risk of single‐point failure. Therefore, this paper proposes a distributed energy management scheme of the hybrid microgrid using the projection function‐based alternating direction method of multipliers (P‐ADMM), which allows each subgrid, i.e., AC subgrid and DC subgrid, to make day‐ahead schedules independently with information exchanges while obtaining the optimal energy management solution. The energy management problem of the hybrid microgrid is formulated as a mixed‐integer quadratic programming (MIQP) model, considering DER and energy storage system operation constraints, system operation constraints, and converter operation constraints. Then, the MIQP model is decomposed and distributed into smaller‐scale QP models between subgrids using the P‐ADMM algorithm, which can handle binary variables through projection functions. The numerical results conducted on the hybrid microgrid demonstrate that the proposed distributed scheme can effectively achieve optimal energy management for the hybrid AC/DC microgrid in a distributed manner.
THE VALUE OF BICHRONOUS ONLINE FACILITATION TO PROMOTE STUDENT ENGAGEMENT IN A TEACHER EDUCATION COURSE (2022)

THE VALUE OF BICHRONOUS ONLINE FACILITATION TO PROMOTE STUDENT ENGAGEMENT IN A TEACHER EDUCATION COURSE
On the Achieved Sum-Rate for Different Handset Grips (2014)

This letter presents the results of analysis of data from a measurement campaign, carried out in Aalborg city, Denmark. The Virtual Signal to Interference plus Noise Ratio (VSINR) algorithm was employed in order to discover the achieved sum rate in cellular network systems. The results focus on the effect different handset (HS) grips have on the data rate achievement.
Intraindividual comparison of cytokine and prostaglandin levels with and without low-energy, high-frequency femtosecond laser cataract pretreatment after single-dose topical NSAID application (2020)

Low pulse energy femtosecond laser pretreatment did not trigger any additional IL and only a small but statistically significant increase of PG release in the anterior chamber after a single-dose of topical nonsteroidal antiinflammatory drug administered 30 minutes before the start of cataract surgery. The findings indicated that the minor inflammatory reaction was due to the lower pulse energy concept applied by the femtosecond laser.
Targeting Breast Cancer with T Cells Redirected to the Vasculature. Addendum (2012)

Abstract : The overall objective of this project is to develop targeted therapy tools directed against the breast cancer vasculature. We aim to bypass many obstacles in the field by developing a treatment based on the targeting of tumor blood vessels with T cells bearing chimeric immune receptors (CIRs). We have constructed and tested first generation CIR lentiviral vectors targeting hTEM1, which were derived from a panel of scFvs of varying affinity. These constructs signal through CD3 but can be augmented by the addition of costimulatory molecules (CD28 and 4-1BB). In vitro, only T cells bearing the scFv78 CIR were activated upon co-culture with recombinant hTEM1 protein. However, no activation was observed when scFv78 CIR bearing T cells were co-cultured with cells expressing hTEM1 on the surface. Additional strategies, including hinge elongation and the utilization of loadable CIR bearing T cells, also failed to elicit a response against the hTEM1 bearing target cells. We engineered a new yeast-display scFv library from patients with ovarian cancer to isolate a second generation of anti-TEM1 scFvs. We validated a panel of multivalent antibodies for binding to recombinant proteins by ELISA assays.. We have generated CIRs against PSMA using scFv (PZ1) and T cells bearing PZ1 and CD28 produce a robust polyfunctional repertoire of cytokines. A tumor vascular mouse model expressing human TEM1 was developed and PET imaging with [124I]-MORAb-004 indicated TEM1-specific accumulation of antibody. We have established optimized HSV-tk as extra safety and tracer for PET imaging.