gebhart/patrepeval huggingface dataset:
Development of Scotopic Visual Thresholds in Retinopathy of Prematurity (2007)

The slower development of parafoveal compared with peripheral thresholds in subjects with a history of ROP is evidence that the late-maturing parafoveal rods are more affected by the ROP disease process.
Improving Corrosion Resistance of Mg10Gd Alloy (2013)

In a screening test, typical traditional alloying elements for magnesium (Al, Mn, Zn, Y) were added to Mg10Gd alloy to study their influence on its corrosion resistance. The Mg10Gd1Mn alloy was identified as the most promising ternary alloy system. While addition of Gd alone disturbs the passive film formation the presence of Mn is beneficial for recovery of the passivity. Performance of the Mg10Gd1Mn alloys is comparable to high purity Mg.
Sentiment Analysis of Product Reviews (2009)

Sentiment analysis is a kind of text classification that classifies texts based on the sentimental orientation (SO) of opinions they contain. Sentiment analysis of product reviews has recently become very popular in text mining and computational linguistics research. The following example provides an overall idea of the challenge. The sentences below are extracted from a movie review on the Internet Movie Database: “It is quite boring...... the acting is brilliant, especially Massimo Troisi.” In the example, the author stated that “it” (the movie) is quite boring but the acting is brilliant. Understanding such sentiments involves several tasks. Firstly, evaluative terms expressing opinions must be extracted from the review. Secondly, the SO, or the polarity, of the opinions must be determined. For instance, “boring” and “brilliant” respectively carry a negative and a positive opinion. Thirdly, the opinion strength, or the intensity, of an opinion should also be determined. For instance, both “brilliant” and “good” indicate positive opinions, but “brilliant” obviously implies a stronger preference. Finally, the review is classified with respect to sentiment classes, such as Positive and Negative, based on the SO of the opinions it contains.
The role of sedation tests in identifying sedative drug effects in healthy volunteers and their power to dissociate sedative-related impairments from memory dysfunctions (2006)

The study investigated whether four specified drugs would show similar patterns on tests considered to measure sedation. In addition, their drug-effect patterns on sedation and memory performance were compared to determine whether the sedative effects could be differentiated from the memory effects. Two double-blind, placebo-controlled, crossover studies, each with 16 healthy volunteers, were performed, one testing lorazepam (2.5 mg) and mirtazapine (15 mg) and the other olanzapine (10 mg) and haloperidol (2.5 mg). Subjective sedation was assessed by means of visual analogue scales (VAS) and objective sedation using a simple-reaction-time (SRT) task and a choice-reaction-time (CRT) task, code substitution (symbol digit substitution test (SDST)) and the peak velocity of saccadic eye movements (SEM). A verbal memory test (VMT) was administered to evaluate memory capacity. Apart from haloperidol, all drugs proved to impair performance on all five sedation indices. Contrary to the VAS, the objective measures yielded different response profiles. Two types of drug-effect patterns emerged: one for greater impairments in response speed (SRT, SEM) and one for greater impairments in information processing (CRT, SDST). Lorazepam and olanzapine impeded memory performance, whereas mirtazapine did not. With the use of standardized scores it proved possible to differentiate between the size of the effects of the drugs on the sedation and memory tests. To accurately assess the level and nature of sedation and to differentiate sedation from memory impairments different types of sedation measures are required. Besides studying the subjective effects, it is recommended to also test psychomotor responses and information processing speed.
Toward through-process layout quality metrics (2005)

Quality of a layout has the most direct impact in the manufacturability of a design. Traditionally, layout quality is ensured in the first order by design rules, i.e. if a layout is free of design rules violation, it is a good layout. It is assumed such a layout will be fabricated to specification. Moreover, a design rule clean layout also ensures the electrical performance of the circuit it represents. There are other layout quality measures, e.g. random defects yield of a layout is modeled by critical area, systematic defects yield is sometime measured by a weighted score of recommended design rules. All the traditional layout quality measures are computed with drawn layout shapes. In the advent of low K1 lithography and the increasing variability of process technologies beyond 90nm, nominal layout quality measures need to be revisited. Traditionally, nominal electrical properties such as L-eff and W-eff are extracted from drawn layout, and the corner cases are estimated with worst case process conditions. Most of these parameters are layout pattern dependent. As a matter of fact, they can be systematic through process and can have large impact in the modeling of circuit parameters [1]. In this paper, we investigate a through process layout quality measure, in which we extract through process electrical parameters from simulated through process resist contours. We showed a mechanism to compute a statistical model that predicts through process electrical parameters from the process parameter variation. We demonstrated that such computation is practical.
Nitric oxide as a regulator of B. anthracis pathogenicity (2015)

Nitric oxide (NO) is a key physiological regulator in eukaryotic and prokaryotic organisms. It can cause a variety of biological effects by reacting with its targets or/and indirectly inducing oxidative stress. NO can also be produced by bacteria including the pathogenic Bacillus anthracis; however, its role in the infectious process only begins to emerge. NO incapacitates macrophages by S-nitrosylating the intracellular proteins and protects B. anthracis from oxidative stress. It is also implicated in the formation of toxic peroxynitrite. In this study we further assessed the effects of B. anthracis NO produced by the NO synthase (bNOS) on bacterial metabolism and host cells in experiments with the bNOS knockout Sterne strain. The mutation abrogated accumulation of nitrite and nitrate as tracer products of NO in the culture medium and markedly attenuated growth in both aerobic and microaerobic conditions. The regulatory role of NO was also suggested by the abnormally high rate of nitrate denitrification by the mutant in the presence of oxygen. Anaerobic regulation mediated by NO was reflected in reduced fermentation of glucose by the mutant correlating with the reduced toxicity of bacteria toward host cells in culture. The toxic effect of NO required permeabilization of the target cells as well as the activity of fermentation-derived metabolite in the conditions of reduced pH. The host cells demonstrated increased phosphorylation of major survivor protein kinase AKT correlating with reduced toxicity of the mutant in comparison with Sterne. Our global proteomic analysis of lymph from the lymph nodes of infected mice harboring bacteria revealed numerous changes in the pattern and levels of proteins associated with the activity of bNOS influencing key cell physiological processes relevant to energy metabolism, growth, signal transduction, stress response, septic shock, and homeostasis. This is the first in vivo observation of the bacterial NO effect on the lymphatic system.
Considerations for name resolution in heterogeneous mobile networks of the future (2011)

The new generation network or future Internet will be heterogeneous not only in terms of link layer technologies but also in network layer protocols and addressing (or locating) schemes. The ID/locator split concept will be applied to the protocol stack so that heterogeneity of the network layer protocols/locators would be hidden from the transport and application layers. The applications identify communication peer hosts by their hostnames or IDs which are mapped to locators as the packets are pushed down the protocol stack. Hosts obtain hostname-to-ID&locator mapping records from hostname registries. The records are updated as mobile hosts move and acquire different locators. In this paper, we discuss a scheme of hostname formation and present some considerations for registering, retrieving, and updating the mapping records so that mobility is supported well in heterogeneous networks of the future.
Left‐Handed Helical Twists in “Mixed β‐Peptides” Derived From Alternating C‐Linked Carbo‐β3‐Amino Acids and β‐hGly Units (2004)

Ambidextrous peptides: Novel mixed β-peptides were synthesized from alternating C-linked carbo-β3-amino acid and β-homoglycine residues. The peptides form unprecedented left-handed 10/12 and 12/10 helices (see picture) in addition to the corresponding right-handed helices. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z53467_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Fast Near‐Infrared Photodetection Using III–V Colloidal Quantum Dots (2022)

Colloidal quantum dots (CQDs) are promising materials for infrared (IR) light detection due to their tunable bandgap and their solution processing; however, to date, the time response of CQD IR photodiodes is inferior to that provided by Si and InGaAs. It is reasoned that the high permittivity of II-VI CQDs leads to slow charge extraction due to screening and capacitance, whereas III-Vs-if their surface chemistry can be mastered-offer a low permittivity and thus increase potential for high-speed operation. In initial studies, it is found that the covalent character in indium arsenide (InAs) leads to imbalanced charge transport, the result of unpassivated surfaces, and uncontrolled heavy doping. Surface management using amphoteric ligand coordination is reported, and it is found that the approach addresses simultaneously the In and As surface dangling bonds. The new InAs CQD solids combine high mobility (0.04 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> ) with a 4× reduction in permittivity compared to PbS CQDs. The resulting photodiodes achieve a response time faster than 2 ns-the fastest photodiode among previously reported CQD photodiodes-combined with an external quantum efficiency (EQE) of 30% at 940 nm.
Multiscale Imaging of Gas Adsorption in Shales (2017)

Abstract Four intact one-inch diameter cores from different shale plays (Barnett, Haynesville, Eagle Ford, and Permian Basin) were analyzed for their gas storage capacity using a novel multiscale imaging methodology spanning from cm- to nm-scale. Gas storage capacity was investigated at the core-scale with carbon dioxide (CO2) and krypton (Kr) using X-ray computed tomography (CT) with voxel dimensions of 190×190×1000 μm. Also, 2D tiled images were acquired using a scanning electron microscope (SEM) and stitched together to form one-inch diameter mosaics with a pixel resolution of 1.5 μm. Multiscale image registration was then carried out to align the CT data with the SEM mosaics. Energy dispersive spectroscopy (EDS) generated elemental spectra maps and subsequent component maps for regions with either substantial or minimal gas storage to assess the interplay of structural features (e.g., fractures) and matrix composition with respect to gas accessibility and adsorption. Registration of CT scans (vacuumed and gas-filled) as well as 190 µm-resolution CT-derived gas storage maps with 1.5 µm-resolution SEM mosaics is straight forward for samples with dense features (such as calcite-filled fractures) that are resolvable by CT imaging. Alignment methods were developed for samples lacking these features including registration marks using silver paint and intermediate resolution microCT scans with cubic voxel dimensions of 27 μm. Once aligned, the relationship of enhanced adsorption zones with open fractures and reduced adsorption regions with secondary mineralization (such as nodules) is apparent for the carbonaceous samples. For the clay-rich Barnett sample, fracture-filling calcite is associated with reduced adsorption similar to the other samples; however, secondary carbonate cementation within the clay matrix aligns with regions with substantial Kr and CO2 gas storage. In contrast, clay-rich matrix regions lacking secondary carbonate cementation exhibit minimal gas storage potential. Causes for this unexpected result include reduced gas accessibility and, possibly, low organic matter content in the clay-rich matrix compared to secondary cemented matrix. These gas adsorption experiments prove the feasibility of dynamic core- to nm-scale CT/SEM/EDS image registration to improve sample characterization. To our knowledge, this is the first investigation of core-scale CO2 gas adsorption employing multiscale imaging. CT and SEM image registration reveal spatial details regarding gas accessibility and storativity at the core-scale. This work also supports the potential of carbon storage in shale formations as well as guides engineers toward optimal CO2 injection zones for enhanced gas recovery.
Scanning tunneling microscopy study of superconductivity, magnetic vortices, and possible charge-density wave inTa4Pd3Te16 (2015)

${\mathrm{Ta}}_{4}{\mathrm{Pd}}_{3}{\mathrm{Te}}_{16}$ is a newly discovered layered superconductor with quasi-one-dimensional (1D) structure. Recent thermal transport measurements show the possible existence of nodes in the superconducting gap. Here we report low-temperature scanning tunneling microscopy/spectroscopy study on ${\mathrm{Ta}}_{4}{\mathrm{Pd}}_{3}{\mathrm{Te}}_{16}$ single crystals. We observed stripelike structure composed of atom chains on the cleaved ($\overline{1}03)$ surface. There exists charge-density-wave (CDW)-like modulations along stripes with commensurate periods. Meanwhile, the tunneling conductance shows an s-wave-like superconducting gap. The magnetic vortex mapped at low field is highly anisotropic with a bound state in the core. At increased field, strong vortex overlapping is directly observed and the bound state is suppressed, indicating the delocalization of the superconducting quasiparticles. Our observations suggest that ${\mathrm{Ta}}_{4}{\mathrm{Pd}}_{3}{\mathrm{Te}}_{16}$ is of multiband superconductivity with strong 1D characters, which possibly coexist with CDW transition.
Pairing and excitation spectrum in dopedt-Jladders (1994)

Exact-diagonalization studies for a doped t-J ladder (or double chain) show hole pairing in the ground state. The excitation spectrum separates into a limited number of quasiparticles which carry charge +\ensuremath{\Vert}e\ensuremath{\Vert} and spin 1/2 and a triplet mode. At half-filling the former vanish but the latter evolves continuously into the triplet band of the spin liquid. At low doping the quasiparticles form a dilute Fermi gas with a strong attraction but simultaneously the Fermi wave vector, as would be measured in photoemission, is large.
Supplementary Figure 1 from A Phase 2/3 Multicenter, Randomized, Open-Label Study to Compare the Efficacy and Safety of Lenalidomide Versus Investigator's Choice in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (2023)

&lt;p&gt;DLC-001 Study Design (CONSORT diagram)&lt;/p&gt;
Dwarf or Giant: The Influence of Interpupillary Distance and Eye Height on Size Perception in Virtual Environments (2017)

This paper addresses the question: to what extent can deliberate manipulations of interpupillary distance (IPD) and eye height be used in a virtual reality (VR) experience to influence a user's sense of their own scale with respect to their surrounding environment - evoking, for example, the illusion of being miniaturized, or of being a giant? In particular, we report the results of an experiment in which we separately study the effect of each of these body scale manipulations on users' perception of object size in a highly detailed, photorealistically rendered immersive virtual environment, using both absolute numeric measures and body-relative actions. Following a real world training session, in which participants learn to accurately report the metric sizes of individual white cubes (3''-20'') presented one at a time on a table in front of them, we conduct two blocks of VR trials using nine different combinations of IPD and eye height. In the first block of trials, participants report the perceived metric size of a virtual white cube that sits on a virtual table, at the same distance used in the real-world training, within in a realistic virtual living room filled with many objects capable of providing familiar size cues. In the second block of trials, participants use their hands to indicate the perceived size of the cube. We found that size judgments were moderately correlated (r = 0.4) between the two response methods, and that neither altered eye height (± 50cm) nor reduced (10mm) IPD had a significant effect on size judgments, but that a wider (150mm) IPD caused a significant (μ = 38%, p &lt; 0.01) decrease in perceived cube size. These findings add new insights to our understanding of how eye height and IPD manipulations can affect peoples' perception of scale in highly realistic immersive VR scenarios.
Vision Loss Secondary to Autologous Adipose Stem Cell Injections (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
Low‐frequency restoration (1989)

Abstract In magnetic resonance imaging, if the object of interest is known to be spatially bounded within the image field‐of‐view. then the high‐intensity, low spatial frequencies can be determined by postprocessing. This allows the system receiver gain to be increased, thereby decreasing the quantization noise from the analog‐to‐digital converters. No imaging sequence modifications are required. © 1989 Academic Press. Inc.
Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Exhibits Tumor Suppressor Properties in K562 Cells by Dephosphorylating Bcr-Abl. (2007)

Abstract Regulation of protein phosphorylation by concerted action of protein kinases and phosphatases is important for normal physiological processes. Altered function or expression of one or more components of these regulatory molecules leads to many pathological conditions including cancer. We have previously shown that the truncated form of the receptor-type protein tyrosine phosphatase PTPROt predominantly expressed in haematopoietic cells is suppressed in Chronic Lymphocytic Leukemia (B-CLL). A direct correlation of CpG island methylation and reduced expression of the gene was observed in primary CLL samples and in several leukemia cell lines. To assess the functional significance of loss of PTPROt function in leukemia, we selected K562 cells as a model system, as PTPROt expression is silenced in these cells and is reactivated upon treatment with DNA hypomethylating agents. Ectopic expression of the catalytically active PTPROt inhibited growth of K562 cells and their clonogenic survival in soft agar (a characteristic of cancer cells). Further, cells expressing PTPROt exhibited delayed entry into S-phase from G0/G1 phase. Induction of apoptosis increased significantly in K562 cells expressing functional phosphatase upon serum withdrawal or exposure to the apoptogenic agent camptothecin. Tumorigenic potential of K562 cells in athymic nude mice was also significantly reduced upon ectopic expression of PTPROt. Finally, we demonstrate that the Bcr-Abl fusion protein, product of abnormal chromosomal translocation [t(9;22)] in chronic myelogenous leukemia, is a substrate of PTPROt. Tyrosine phosphorylation of this potent kinase was markedly reduced in K562 cells expressing the catalytically active PTPROt. Enhanced dephosphorylation of Bcr-Abl by PTPROt both in vivo and in vitro explains the observed phenotypes of the PTPROt expressing K562 cells. These data taken together delineate the molecular mechanism of tumor suppressor function of PTPROt in leukemic cells characterized by Philadelphia chromosome. (This work was supported by a grant CA101956 from the National Institutes of Health).
Are Veterans Seeking Veterans Affairs’ Primary Care as Healthy as Those Seeking Department of Defense Primary Care? A Look at Gulf War Veterans’ Symptoms and Functional Status (2002)

Objective This study compared Gulf War veterans seeking VA primary care with Gulf War veterans seeking treatment from a Department of Defense primary care clinic on measures of physical symptoms, psychiatric complaints, and functional status. Additionally, the association between employment status and health was examined. Methods Analysis was based on the responses of consecutive patients attending the Gulf War Primary Care clinics at either the VA Puget Sound Health Care System in Seattle, WA (N = 223), or the Walter Reed Army Medical Center in Washington, DC (N = 153), between March 1998 and September 1999. Results After controlling for demographic variables, Gulf War veterans who sought VA care reported significantly more anxiety and PTSD symptoms than active duty military personnel. The groups did not differ on somatic complaints or summary scores from the SF-36. Employment status was significantly, independently, and consistently associated with greater psychiatric symptoms, physical symptoms, and decreased functional status. Conclusions Our findings reveal important differences in health status between veterans seeking primary care at a VA and a Department of Defense facility, differences that are in part related to employment status. Both groups report symptoms of psychiatric distress and decreased functional status, though VA patients are more impaired. Research findings based on clinical samples of veterans at VA sites may not generalize to Gulf War veterans still on active duty (and vice versa).