gebhart/patrepeval huggingface dataset:
Anchored Sheet Pile Wall Analysis Using Fixed End Method Without Estimation of Point of Contraflexure (2007)

The fixed end method used for the design of anchored sheet pile walls has been used with success since before World War II; however, computational limitations have forced designers to use simplifications such Hermann Blum developed. The original method called for the use of an “elastic line” solution, where the penetration of the sheet piling below the excavation line was estimated using statically indeterminate beam theory. This paper develops the governing equations for the “elastic line” method for a simple case and presents the solution in two ways: parametrically using charts, and for specific cases using an online computer algorithm. Comparison with other solution techniques is presented, and suggestions for broader applications are made. The adjustment of the penetration for the residual toe load is also discussed, and the limitations of current practice in this adjustment are detailed.
A Pragmatic Approach for Predicting the Scalability of Parallel Applications (2012)

Predicting the scalability of parallel applications is becoming crucial now that the number of cores in modern CPUs doubles roughly every two years. Traditional ways to get some understanding of the scalability of a parallel application rely on extensive experiments or detailed application models. Both are very time consuming and often hard to use. This paper presents PreSca, a pragmatic system for predicting the scalability of parallel applications. PreSca uses function approximation techniques to model scalability with an analytical performance function extracted from a set of measurements. By considering the application as a black-box without requiring any knowledge about its internals, PreSca can be applied with little effort to any parallel application. We show how PreSca can be used statically to predict the scalability of a given application and decide which synchronization primitive scales best for it as well as how it can be used on-line to dynamically assist scheduling decisions and adjust core assignment. In some sense, PreSca shows, for the first time, how function approximation can be used to predict the scalability of parallel applications in a completely general way. We extensively evaluated PreSca using a large number of parallel benchmarks, including some that use locks and some that use transactional memory. We also consider two different multicore systems. Our evaluation shows that PreSca produces accurate results. More specifically: (1) PreSca’s interpolations based on only 8 measurements have 90th percentile of error lower than 15%, (2) PreSca’s extrapolations using measurements with up to m cores predict the performance for n ≤ 2m cores with errors lower than 20 % in most cases, and (3) PreSca’s on-line scheduler determines the optimal thread count using fewer than 7 measurements with errors lower than 3 % on average. 1.
Effect of Bombyx mori Paralytic Peptide on Recombinant CHO Cell Culture (2007)

Previously we reported HeLa cell growth-promoting effect of Bombyx mori paralytic peptide (BmPP). BmPP is a multifunctional cytokine-like peptide consisting of 23 amino acid residues. It has been reported that the core region of BmPP shows a striking similarity to the C-terminal β-loop domain of epidermal growth factor (EGF). Its structural similarity to EGF suggests that BmPP promotes HeLa cell growth via the EGF receptors. Chinese hamster ovary (CHO) cells are by far the most commonly used production vehicles for recombinant glycoproteins. Recombinant CHO (rCHO) cells producing human EPO were used in this study. When BmPP is added to the culture medium in concentration of 10-9M, 10-8M and 10-7M, BmPP prolonged longevity of rCHO cells in serum-free medium. It is considered that the structural similarity between BmPP and EGF may lead to the interaction of BmPP to EGF receptor of rCHO cells to prolong longevity of the cells.
Plasticity of developing cerebellar cells in vitro studied with antibodies against the NG2 antigen (1987)

The NG2 antigen, a chondroitin-sulfate proteoglycan, is a cell surface marker for a class of smooth protoplasmic astrocytes found throughout the brain and at high frequency in the cerebellar molecular layer (Levine and Card, 1987). To study the development of the cerebellar astrocytes at the level of the single cell, we have analyzed the distribution of the NG2 antigen by indirect immunofluorescence in dissociated cell cultures prepared from postnatal cerebella and compared that distribution to the distribution of several other cell surface and intracellular antigens that identify specific cell types in cultures of nervous tissue. When cerebellar cells from 5 d rat pups were grown in a medium containing 10% fetal calf serum, the NG2-labeled cells, which constituted 0.1-1.0% of the total glial cells present, contained glial fibrillary acidic protein (GFAP)-immunoreactive filaments and bound monoclonal antibody A2B5, a surface marker for neurons and some astrocytes. Approximately 30% of the NG2-labeled cells were also labeled with tetanus toxin, an additional surface marker for neurons and immature astrocytes. Less than 2% of the cells were labeled with antibodies against galactocerebroside or with monoclonal antibody O1, both of which are surface markers for oligodendrocytes. About half the NG2-labeled cells exhibited high-affinity uptake of 3H-GABA, and this uptake was partially inhibited by both beta-alanine and DABA. Thus, the NG2 antigen is a cell surface marker for a subpopulation of the type II or fibrous astrocytes present in the cultures. When the cerebellar cells were grown in a chemically defined, serum-free medium, the NG2-labeled cells had a stellate morphology and between 50-60% of the cells bound tetanus toxin. Although almost all the cells bound antibody A2B5, less than 5% of the cells expressed either of the oligodendrocyte surface markers or GFAP immunoreactivity. As was the case with cells grown in serum-containing medium, 60% of the NG2-labeled cells had high-affinity uptake of 3H-GABA. However, this uptake was inhibited by DABA but not by beta-alanine. This phenotype may be the in vitro analog of the NG2-labeled, filament-lacking, smooth protoplasmic astrocytes identified in the intact adult cerebellum. The expression of these 2 phenotypes could be reversed by switching the tissue culture medium within 5 d of plating the cells. These results demonstrate that the in vitro environment can influence the phenotypic properties expressed by developing cerebellar astrocytes and suggest that smooth protoplasmic astrocytes may be developmentally related to glial cells of the O-2A lineage.
Knee motion after tibial osteotomy for arthrosis: Kinematic analysis of 7 patients (1993)

The in vivo kinematics of the knee in 7 patients with moderate medial gonarthrosis was analyzed before and 6 months after high tibial osteotomy using roentgen stereophotogrammetric analysis. The inclination of the femorotibial helical axis of rotation did not change with knee flexion or after surgery. The femorotibial rotation increased after surgery. No consistent change in patellar position after surgery was found. Patella translated laterally as the knee was flexed with a maximum patellar translation of about 15 mm and rotated internally with a maximum patellar internal rotation of about 15 degrees. There was no significant change in patellar translation or rotation after surgery. There was a good concordance regarding the size of the tibial wedge removed during surgery, calculated from the Hip-Knee-Ankle radiographs and from the roentgen stereophotogrammetric measurements.
Next Generation Sequencing Assay for Detection of Circulating HPV DNA (cHPV-DNA) in Patients Undergoing Radical (Chemo)Radiotherapy in Anal Squamous Cell Carcinoma (ASCC) (2020)

<b>Background:</b> Following chemo-radiotherapy (CRT) for human papilloma virus positive (HPV+) anal squamous cell carcinoma (ASCC), detection of residual/recurrent disease is challenging. Patients frequently undergo unnecessary repeated biopsies for abnormal MRI/clinical findings. In a pilot study we assessed the role of circulating HPV-DNA in identifying "true" residual disease. <b>Methods:</b> We prospectively collected plasma samples at baseline (<i>n</i> = 21) and 12 weeks post-CRT (<i>n</i> = 17). Circulating HPV-DNA (cHPV DNA) was measured using a novel next generation sequencing (NGS) assay, panHPV-detect, comprising of two primer pools covering distinct regions of eight high-risk HPV genomes (16, 18, 31, 33, 35, 45, 52, and 58) to detect circulating HPV-DNA (cHPV DNA). cHPV-DNA levels post-CRT were correlated to disease response. <b>Results:</b> In pre-CRT samples, panHPV-detect demonstrated 100% sensitivity and specificity for HPV associated ASCC. PanHPV-detect was able to demonstrate cHPV-DNA in 100% (9/9) patients with T1/T2N0 cancers. cHPV-DNA was detectable 12 weeks post CRT in just 2/17 patients, both of whom relapsed. 1/16 patients who had a clinical complete response (CR) at 3 months post-CRT but relapsed at 9 months and 1/1 patient with a partial response (PR). PanHPV-detect demonstrated 100% sensitivity and specificity in predicting response to CRT. <b>Conclusion:</b> We demonstrate that panHPV-detect, an NSG assay is a highly sensitive and specific test for the identification of cHPV-DNA in plasma at diagnosis. cHPV-DNA post-treatment may predict clinical response to CRT.
Postural tremor suppression is dependent on thalamic stimulation frequency (2006)

Deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) reduces tremor in people with essential tremor (ET), yet the dependence of tremor suppression on stimulation frequency remains unclear. To address this issue, we tested tremor suppression for three 15-second measurements during a variety of stimulation frequencies in 11 ET patients treated with VIM DBS. Stimulation frequencies at or above 100 Hz produced maximal benefit; higher frequencies provided no additional benefit. If this short-term measure predicts long-term response in routine activities at home, then this stimulation frequency setting will prolong battery half-life compared to higher frequency settings. These findings suggest that ET patients treated with VIM DBS may receive adequate benefit from stimulation frequencies about 100 Hz and this setting compared to commonly used higher settings will prolong battery life of surgically implanted pulse generators.
Land-vehicle navigation using GPS (1999)

The Global Positioning System (GPS) has made navigation systems practical for a number of land-vehicle navigation applications. Today, GPS-based navigation systems can be found in motor vehicles, farming and mining equipment, and a variety of other land-based vehicles (e.g., golf carts and mobile robots). Each of these applications is discussed and the reader is introduced to some of the issues involved with each one. One particular technical aspect of navigation for land vehicles is discussed. Specifically, the research discussed in this paper presents a quantitative examination of the impact that individual navigation sensors have on the perfomance of a land-vehicle navigation system. A range of navigation sensor performance levels and their influence on vehicle positioning accuracy are examined. Results show that, for a typical navigation system, positioning error is dominated by the accuracy of the position fixes provided by the GPS receiver when GPS position fixes are available and by the rate gyro's bias drift when GPS position fixes are not available. Furthermore, results show that the accuracy of the GPS position fixes has a significant impact on the relative contributions that each dead-reckoning navigation sensor error makes. The implications of these results for navigation system design and sensor design are discussed.
Identification of a fibronectin‐binding domain within the Campylobacter jejuni CadF protein (2005)

The binding of Campylobacter jejuni to fibronectin (Fn), a component of the extracellular matrix, is mediated by a 37 kDa outer membrane protein termed CadF for Campylobacter adhesion to Fn. Previous studies have indicated that C. jejuni binds to Fn on the basolateral surface of T84 human colonic cells. To further characterize the interaction of the CadF protein with Fn, enzyme-linked immunosorbent assays were performed to identify the Fn-binding domain (Fn-BD). Using overlapping 30-mer and 16-mer peptides derived from translated cadF nucleotide sequence, maximal Fn-binding activity was localized to four amino acids (AA 134-137) consisting of the residues phenylalanine-arginine-leucine-serine (FRLS). A mouse alpha-CadF peptide polyclonal antibody (M alpha-CadF peptide pAb) was generated using FRLS containing peptides and found to react with viable C. jejuni as judged by indirect fluorescent microscopy, suggesting that the FRLS residues are surface-exposed. Binding of CadF to purified Fn and INT 407 human epithelial cells was significantly inhibited with peptides containing the Fn-BD. Moreover, a CadF recombinant variant protein, in which the Phe-Arg-Leu residues (CadF AA 134-136) were altered to Ala-Ala-Gly, exhibited a 91% decrease in Fn-binding activity as compared with the wild-type CadF protein. Collectively, these data indicate that the FRLS residues (CadF AA 134-137) of the C. jejuni CadF protein possess Fn-binding activity.
Control of A Friction Launch Automatic Transmission Using a Range Clutch (2006)

Friction Launch transmissions use a wet multi-plate clutch to replace the torque converter in an automatic transmission. The main benefit of this technology is fuel economy improvement as a result of eliminating the losses in the torque converter. By using one of the range clutches inside the transmission instead of an input clutch in place of the converter, the benefits of this integrated friction launch technology, such as reduction in mass, packaging, and cost, can be enhanced. The availability of new automatic transmissions with higher number of speeds and wider overall ratio spreads makes this technology more viable than ever before. This project focuses on control issues with the friction launch clutch which include developing robust control algorithms for launch and creep, and providing damping to the driveline, when required, and ensuring acceptable vehicle drivability. This paper describes in detail the development of vehicle launch control algorithms. Vehicle test data is presented to show that the control strategy developed in this project significantly reduces the gap between the drivability of a starting clutch vehicle and a torque converter equipped vehicle.
Interpretable and accurate prediction models for metagenomics data (2020)

Predomics is a new algorithm that helps in providing reliable and trustworthy diagnostic decisions in the microbiome field. Predomics is in accord with societal and legal requirements that plead for an explainable artificial intelligence approach in the medical field.
Magnetic ordering in clustered Fe-based materials synthesized from laser plasma (abstract) (1996)

Using Mössbauer spectroscopy and the magneto-optical Kerr effect, we investigate how magnetic order arises and develops in Fe/C and Fe/Cr layered mixtures prepared by pulsed laser deposition. Two different magnetic transformations are found to occur in these systems under their thermal annealing. The first is the paramagnetic–ferromagnetic crossover that takes place at annealing temperatures of 420–570 K in dependence on the average iron content. Varying the latter quantity, we also observed the same crossover to the ferromagnetic state. The second transformation is magnetic hardening at 700–800 K. The specific feature of both transformations is that they occur within narrow ranges of annealing temperature (&amp;lt;10 K). The first transformation is supposed to result from an additional iron enrichment of Fe-rich clusters and is associated with magnetic phase transition near the Curie temperature. The cluster enrichment was directly observed with transmission electron microscopy and was also shown in small angle x-ray scattering patterns of the compositionally modulated structures. The observed sharpening of the magnetic behavior near the Curie temperature is presumably a manifestation of the clustered structure. The second transformation is found to be induced by the onset of crystallization and the formation of particles of the new Fe-rich phase.
Effects of Incubation at 4 C on Calcium Uptake and Acrosin Activity in Turkey Spermatozoa (1985)

Turkey semen was diluted 1:1 with a phosphate diluent (Clemson Turkey Semen Diluent) containing radioactively labeled calcium-45 (45Ca) and stored in in vitro at 25 or 4 C to determine the effects of cold-storage on spermatozoa 45Ca permeability. In addition, acrosin activity of semen stored 24 hr at 4 C was compared with that of fresh diluted semen at 25 C. Cold-stored spermatozoa immediately sequestered 45Ca at an exponential rate until the 3 hr disintegrations per min/10(9) spermatozoa equalled that of spermatozoa stored 24 h at 4 C. Washing the spermatozoa after 3 hr incubation reduced the 45Ca of spermatozoa stored at 25 C but not at 4 C. Acrosin activity of spermatozoa diluted 1:1 with CTSD and stored at 4 C for 24 hr was 1.74 times greater than for fresh sperm held 1 hr at 25 C. These results suggest that cooling turkey spermatozoa causes an intracellular influx of calcium ions that may be associated with acrosin formation.
Mode-locked far-infrared p-Ge laser using and offset rf electric field for gain modulation (1998)

Active mode locking of the far-infrared p-Ge laser is achieved via gain modulation with an rf electric field applied at one end of the crystal parallel to the Voigt- configured magnetic field. A small intrinsic voltage is observed between the rf contacts during lasing which significantly impairs the gain and also the achievable intensity and duration of mode-locked pulses. This voltage is directly compensated by applying a bias to the rf contacts. First results give mode-locked pulse durations of ~ 200 ps.
Raised plasma homocysteine as a risk factor for retinal vascular occlusive disease (2000)

Elevated tHcy is an independent risk factor for retinal vascular occlusive disease. Assessment of tHcy may be important in the investigation and management of patients with retinal vascular occlusive disease.
P1E-3 Noninvasive Ultrasonic Elastography of Atherosclerotic Plaques Using Frequency-corrected Autocorrelation Method: A Preliminary Study (2006)

In recent years, ultrasonic elastography has shown promise in noninvasively estimating the elastic properties of the atherosclerotic tissue to evaluate the plaque vulnerability. The cyclic change in blood pressure during the cardiac cycle deforms the atherosclerotic tissue, and the resulting strain is frequently estimated from the phase of autocorrelation between the pre- and post-compressed ultrasonic data. Several researchers have reported that this autocorrelation method (AM) can introduce a bias in displacement estimates due to its inherent assumption of fixed ultrasound center frequency and can result in large errors in strain due to the derivative operation. Fortunately, the center frequency of the ultrasound signal could be estimated from the received ultrasonic signal, and we have previously reported that the frequency-corrected autocorrelation method (FCAM) can increase the elastographic signal-to-noise ratio (SNR <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">e</sub> ) by as much as 2 times over AM. In this paper, we evaluate the FCAM for elastography of atherosclerotic plaques. Through phantom and in vivo experiments, we show that our method can produce high quality elastograms of vascular tissues, which may aid in determining plaque vulnerability
Substrate integrated slab waveguide (SISW) for wideband microwave applications (2003)

A new slab waveguide integrated in planar form has been developed for wideband microwave applications. The guide is synthesized on a substrate by adding an air hole into an SIW (substrate integrated waveguide). Using these techniques, a substrate integrated slab waveguide (SISW) covering the X and Ku bands has been designed and measured. Wideband microstrip transitions are presented with S/sub 21/ lower than 0.75 dB and S/sub 11/ below -15 dB over the entire band. Propagation constant and quality factor measurements are also presented with a Q value of 308.
Non-conservative diffusion and its application to social network analysis (2023)

Abstract Is the random walk appropriate for modelling and analysing social processes? We argue that many interesting social phenomena, including epidemics and information diffusion, cannot be modelled as a random walk, but instead must be modelled as broadcast-based or non-conservative diffusion. To produce meaningful results, social network analysis algorithms have to take into account differences between these diffusion processes. We formulate conservative (random walk-based) and non-conservative (broadcast-based) diffusion mathematically and show how these are related to well-known metrics: PageRank and Alpha-Centrality, respectively. This formulation allows us to unify two distinct areas of network analysis–centrality and epidemic models–and leads to insights into the relationship between diffusion and network structure, specifically, the existence of an epidemic threshold in non-conservative diffusion. We demonstrate, by ranking nodes in an online social network used for broadcasting news, that non-conservative Alpha-Centrality leads to a better agreement with empirical ranking schemes than conservative PageRank. In addition, we give a scalable approximate algorithm for computing the Alpha-Centrality in a massive graph. We hope that our investigation will inspire further exploration of the applications of non-conservative diffusion in social network analysis.
A Generalized Block-Iterative Projection Method for the Common Fixed Point Problem Induced by Cutters (2022)

The block-iterative projections (BIP) method of Aharoni and Censor [Block-iterative projection methods for parallel computation of solutions to convex feasibility problems, Linear Algebra and its Applications 120, (1989), 165--175] is an iterative process for finding asymptotically a point in the nonempty intersection of a family of closed convex subsets. It employs orthogonal projections onto the individual subsets in an algorithmic regime that uses "blocks" of operators and has great flexibility in constructing specific algorithms from it. We extend this algorithmic scheme to handle a family of continuous cutter operators and to find a common fixed point of them. Since the family of continuous cutters includes several important specific operators, our generalized scheme, which ensures global convergence and retains the flexibility of BIP, can handle, in particular, metric (orthogonal) projectors and continuous subgradient projections, which are very important in applications. We also allow a certain kind of adaptive perturbations to be included, and along the way we derive a perturbed Fej\'er monotonicity lemma which is of independent interest.
Characterization of flow-pattern and heat transfer of micro flat heat pipes (2014)

Paper presented to the 10th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Florida, 14-16 July 2014.