gebhart/patrepeval huggingface dataset:
Budget Period 2 Summary Report Part 3: Hywind Maine Project (2015)

This project was performed under the Work for Others—Funds in Agreement FIA-14-1793 between Statoil and the Alliance for Sustainable Energy, manager and operator of the National Renewable Energy Laboratory (NREL). To support the development of a 6-MW spar-mounted offshore wind turbine, NREL performed tasks on behalf of Statoil in the following three categories: 1. Design and analysis 2. Wake modeling 3. Concept resource assessment. This document summarizes the work performed in Work Package (WP) 3, where the spatial variability and influence that relevant parameters have on levelized cost of energy (LCOE) were analyzed. The study allows Statoil to identify areas of interest for floating wind technology and the Hywind concept in particular. This report describes the results of a study that NREL conducted to provide targeted insight into the United States (U.S.) offshore wind resource area that Statoil can use for taking strategic decisions about how to commercialize and market the company’s Hywind technology. The report centers on a new spatio-economic methodology that NREL has developed to assess how variability in spatial parameters can influence levelized cost of energy (LCOE) for different technologies. The method combines wind plant performance modeling, economic modeling, and national geospatial data layers to estimate the cost of potential projects using Hywind technology, considering the following parameters: • Water depth • Possible inshore assembly areas • Wind resource • Existing grid features and potential connection points • Wave regime • Environmentally sensitive areas • Seabed conditions • Competitive use areas • Prospective staging ports The scope of the study covers the major offshore regions within the contiguous United States, including the Atlantic Ocean, Gulf of Mexico, Pacific Ocean, and the Great Lakes. The spatio-economic assessment extends to 92 km (50 nm) off of the nearest land mass, consistent with the available data on wind characteristics. The study is restricted to those locations that meet the depth criteria for Hywind technology—defined as water depths between 100 m to 1,000 m—and only considered sites with net capacity factors that exceed 30%.
Bottromycin. Separation of Biologically Active Compounds and Preparation and Testing of Amide Derivatives (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBottromycin. Separation of Biologically Active Compounds and Preparation and Testing of Amide DerivativesW Miller, L Chaiet, G Rasmussen, B Christensen, J Hannah, A. Katherine Miller, and F WolfeCite this: J. Med. Chem. 1968, 11, 4, 746–749Publication Date (Print):July 1, 1968Publication History Published online26 November 2002Published inissue 1 July 1968https://pubs.acs.org/doi/10.1021/jm00310a603https://doi.org/10.1021/jm00310a603research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Field demonstration of a portable flow immunosensor (1998)

A portable biosensor known as the FAST 2000, developed by the Naval Research Laboratory (NRL) and engineered by Research International, Inc., has been field tested for effectiveness in performing on-site analyses for two selected explosives, TNT and RDX. The biosensor uses antibody recognition of analyte molecules and subsequent fluorescence detection downstream to measure contaminant levels in groundwater and soil. In field trials at military bases identified by the U. S. EPA as priority Superfund cleanup sites, samples containing unknown concentrations of explosives were collected from groundwater monitoring wells at various locations and analyzed in the NRL sensor with no sample pretreatment or concentration. Test sites included the Volunteer Army Ammunition Plant, Chattanooga, TN and Umatilla Army Depot Activity, Umatilla, OR. Field samples were analyzed on-site by the portable FAST 2000, and splits were analyzed by an independent U. S. EPA-certified laboratory with the use of HPLC SW846 Method 8330. Results demonstrated that the FAST 2000 can detect explosives in environmental samples with accuracy and precision. Statistical analyses based on regression curves comparing the FAST 2000 and HPLC methods showed a high degree of correlation, with r2 values between 0.86 and 0.97. The assay system required small sample volumes (150 μl/test) and samples were analyzed in less than 3 min. The sensor was quantitative, with a method detection limit (MDL) of 10 μg/l. Beyond contaminated field samples, appropriate controls, blanks, and interferents were tested in the lab for certification and validation data requirements. Results were evaluated based on accuracy, precision, cost, time, and waste generation. © 1998 John Wiley & Sons, Inc. Field Analyt Chem Technol 2: 341–350, 1998
CROSS SECTIONS FOR ELECTRON EXCITATION OF THE 3914-A (0,0) BAND OF THE N$sub 2$$sup +$ FIRST NEGATIVE SYSTEM. (1967)

Abstract : As part of a study of the emission from nitrogen excited by an electron beam, cross sections for electron excitation of the 3914-A (0,0) band of the N2(+) first negative system were measured for electron energies of 95 to 2023 eV. Because published values for these cross sections differ by factors of two to three, an effort was made to establish the accuracy of the measurements. 3914-A band intensity was measured with two independently calibrated photometers and a scanning spectrometer. A comparison of equipment and joint observations were made with experimenters from two other laboratories. The cross section obtained for the 3914-A band at 95 eV is 1.5 x 10 to the -17th power sq cm, and that at 2023 eV is 3.1 x 10 to the -16th power sq cm. By a simple calculation, one can derive a corresponding efficiency of 0.0043 for the production of the 3914-A band by electrons in air. The excitation cross sections are in reasonable agreement with other recent measurements, but are higher than some values reported earlier. The calculated efficiency is in fair agreement with the results of laboratory efficiency measurements.
Animal Models of Anxiety and Depression (2003)

Animal models of psychiatric conditions such as anxiety and depression attempt to represent some aspect of the etiology, symptomatology, or treatment of these disorders, in order to facilitate their scientific study (Treit, 1994; Mineka, 1985; Marks, 1987; Willner, 1994). Within this broad context, animal models of anxiolytic or antidepressant drug action can be viewed as treatment models concerned with the pharmacological control of human anxiety and depression. Animal models of anxiety, for example, have been particularly useful in the preclmical testing of benzodiazepme-type anxiolytics, in studying the functional relevance of the GABAA-benzodiazepine receptor system, and in characterizing the effects of benzodiazepine antagonists (e.g., Ro 15–1788 [flumazeml]), partial agonists (e.g., CGS 98961, and inverse agonists (e.g., B-CCM). For reviews see Thlebot (1983); La1 and Emmett-Oglesby (1983); File (1984;1985;1987); Crawley (1985); Treit (1985a;1994); Shephard (1986); Gardner (1988); Thiebot et al. (1988); and Lister (1990).
Screening for depression in a diabetic outpatient population (2007)

Depression occurs twice as often in patients with diabetes and is associated with reduced compliance with exercise, diet, and medications. It is also associated with hyperglycemia and increased diabetic complications. Despite evidence that successful treatment is associated with improved glycemic control, many cases of depression are left untreated. Objectives. (1) Evaluate a combination screening strategy in an outpatient population; and (2) explore the association between glycemic control and depressive symptomatology. Methods. Ninety-two patients completed the Patient Health Questionnaire (PHQ-2). Patients with a PHQ-2 score ≥ 1 completed the 16-item Quick Inventory of Depressive Symptomatology (QIDS-SR16). Using the QIDS-SR16, a score of ≤5 corresponded to normal mood, with scores above 5 corresponding to increasing severity of depressive symptoms. Glycemic control was assessed by glycosylated hemoglobin (HbA1c). Results. Using a PHQ-2 cut-off score of ≥3, 37% of the sample screened positive for major depressive disorder (MDD), with an additional 27% reporting sub-threshold symptoms. The depressed group reported significantly more difficulty with reduced interests, insomnia, concentration, self-criticism, energy/fatigue and depressed mood. In terms of glycemic control, there was a marginally significant effect for race and HbA1c. Conclusion. The combined PHQ-2 and QIDS-SR16 can facilitate prompt detection of MDD and provide a means of monitoring specific symptoms and progress once treatment commences.
1-(2,4-Diclorofenil)-1H-pirazóis: Síntese, Análise Estrutural e Interação com os Receptores Canabinóides CB1 (2010)

Este trabalho descreve um metodo para obter catorze enonas [EtO2CC(O)C(R2)=C(R1)OR, onde R = H, Me; R1 = Pr, Ph, 4-MeOC6H4, 4-MeC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-NO2C6H4, Fur-2-il; R2 = H; R1,R2 = -(CH2)3-, -(CH2)4-, - (CH2)5-, -(CH2)6-, 3,4-diidronaftalen-2-il] a partir da acilacao de acetais com cloreto de etil oxalila. A reacao de ciclocondensacao desses substratos com cloridrato de 2,4- diclorofenil hidrazina utilizando irradiacao de ultrassom forneceu uma serie de 1-(2,4-diclorofenil)-3-etilcarboxilato-1H-pirazois em 71-92% de rendimento. Os pirazois sintetizados (R1,R2 = -(CH2)3-, -(CH2)4-, -(CH2)5-, -(CH2)6-) sofreram hidrolise em meio basico conduzindo aos respectivos acidos carboxilicos (94-97%) os quais foram convertidos aos cloretos de acido correspondentes apos reacao com cloreto de tionila. A reacao desses cloretos de acido com aminas primarias (piperidin-1-ilamina, propilamina, 2-morfolin-4-il-etilamina, anilina, 4-metoxifenilamina, 4-nitrofenilamina) conduziram aos respectivos 3-carboxiamida-1-(2,4-diclorofenil)-1H-pirazois em 85-97% de rendimento. Adicionalmente aos dados espectroscopicos, a estrutura dos compostos foi estudada por experimentos de difracao raios-X. Uma vez que os 3-carboxiamida-1- (2,4-diclorofenil)-1H-pirazois sao estruturalmente analogos ao Rimonabanto, um conhecido antagonista dos receptores CB1, foram realizados ensaios de ligacao especifica desses compostos para o receptor canabinoide CB1. O ligante mais promissor, candidato a prototipo, foi o 3-carboxiamida-1-(2,4-diclorofenil)-N-(piperidin-1-il)-4,5,6,7,8,9-hexaidro-1H-ciclocta[c]pirazol o qual deslocou, aproximadamente, 100% do [3H]Rimonabanto nos ensaio realizados.%%%%A method to obtain fourteen enones [EtO2CC(O)C(R2)=C(R1)OR, where R = H, Me; R1 = Pr, Ph, 4-MeOC6H4, 4-MeC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-NO2C6H4, Fur- 2-yl; R2 = H; R1,R2 = -(CH2)3-, -(CH2)4-, -(CH2)5-, -(CH2)6-, 3,4-dihydronaphthalen-2-yl] from acylation of acetals with ethyl oxalyl chloride is reported. The cyclocondensation reaction of these substrates with 2,4-dichlorophenyl hydrazine hydrochloride under ultrasound irradiation furnished a series of 1-(2,4-dichlorophenyl)-3-ethylcarboxylate-1Hpyrazoles in 71-92% yields. The pyrazole ester derivatives with R1,R2 = -(CH2)3-, - (CH2)4-, -(CH2)5-, and (CH2)6- suffered hidrolysis reaction in basic media supplied the carboxylic acids (94-97%) which were converted to the corresponding acid chlorides after reaction with thionyl chloride. The reaction of acid chlorides with primary amines (piperidin-1-ylamine, propylamine, 2-morpholino-4-yl-ethylamine, aniline, 4-metoxiphenylamina, 4-nitrophenylamina) led to respective 3-carboxyamide-1-(2,4-dichlorophenyl)-1H-pyrazoles in 85-97% yields. In addition to spectroscopic data the structure of the compounds was studied by X-ray diffraction experiments. Since, the 3-carboxyamide-1-(2,4-dichlorophenyl)-1H-pyrazoles are structurally similar to Rimonabant, a known antagonist of CB1 receptors, binding assays were performed to the cannabinoid receptor CB1. The most…
Tetradecane 1, 14-Dicarboxylic Acid Production from n-Hexadecane by Candida cloacae (1972)

The better condition of cultivation for tetradecane 1, 14-dicarboxylic acid (DC-16) production from n-hexadecane (n-C16) by Candida cloacae MR-12 was investigated by using acetic acid as carbon source for the growth. In general, the condition suitable for the growth was also favorable for the production of DC-16. The change of pH during cultivation, the use of NaOH solution as pH controlling agent after pH-change and the addition of antifoam stimulated the production of DC-16. Under the optimum conditions where the culture medium contained 15%(v/v) n-C16, 1.4%(w/v) acetic acid, inorganic salts and growth factors, and pH was changed from 6.5 to 7.75 at 16 hr after the inoculation, the highest level of DC-16 production was attained after about 72 hr cultivation and the amount of the product accumulated was 61.5g per liter of the medium. When a mixture of various n-alkanes was used as starting material, DCs corresponding to the respective n-alkanes were produced as mixture.
An accurate and efficient scheme for propagating the time dependent Schrödinger equation (1984)

A new propagation scheme for the time dependent Schrödinger equation is based on a Chebychev polynomial expansion of the evolution operator Û=exp(−iĤt). Combined with the Fourier method for calculating the Hamiltonian operation the scheme is not only extremely accurate but is up to six times more efficient than the presently used second order differencing propagation scheme.
A parallel approximation algorithm for positive linear programming (1993)

We introduce a fast parallel approximation algorithm for the positive linear programming optimization problem, i.e. the special case of the linear programming optimization problem where the input constraint matrix and constraint vector consist entirely of positive entries. The algorithm is elementary, and has a simple parallel implementation that runs in polylog time using a linear number of processors.
Teaching Neuro Images : Rapidly progressive leukoencephalopathy in mitochondrial complex I deficiency (2013)

<b>Background:</b> Oxidative stress participated in the pathogenesis of interstitial lung diseases. This prospective study is the first experimental work that evaluated the effect of Fenugreek (FG) and its phenolylic extract on oxidative stress and lung fibrosis in experimental model. <b>Methods:</b> A single dose of Bleomycine was injected intratracheally in forty male wistar rats (4mg/kg). Two days after inducing lung injuries, animals were randomly divided in four groups of 10 rats: G1, G2, G3 and G4. G1received FG Seed Polyphenol Extract at a dose of 200 mg kg by daily gavage.G2 received FG seeds powder mixed with food at levels of up to 20%. G3 received an equal volume of water (6.5 ml kg/, daily gavage). G4 did not receive any treatment. Two weeks after inducing lung fibrosis, rats were sacrificed and we evaluated stress biomarkers (TAS:Total Antioxdant Status, Malon DiAldehyde:MDA) in serum and inflammatory index, fibrosis score and TGF beta density in injured lung. <b>Results:</b> Comparatively to control groups G3 and G4, ANOVA statiscal study, demonstrated that FG Seed Polyphenols Extracts ameliorated TAS and reduced inflammtory index and TGFβ density in G1 and seeds powder of FG reduced MDA a marker of oxidant stress and inflammatory score in G2 (p &lt;0,05). However, Ashcroft semi-quantitative assessing of fibrosis score has not revealed significant differences between the four groups (p&gt;0,05). <b>Conclusion:</b> This study demonstrated that FG 9 has potent antioxidant and anti-inflammatory activities but has not an anti-fibrotic effect confirming that besides inflammation, other factors probably interfere in the pathogenesis of pulmonary fibrosis.
Altered-Function p53 Missense Mutations Identified in Breast Cancers Can Have Subtle Effects on Transactivation (2020)

Mutations of the sequence-specific master regulator p53 that alter transactivation function from promoter response elements (REs) could result in changes in the strength of gene activation or spectra of genes regulated. Such mutations in this tumor suppressor might lead to dramatic phenotypic changes and diversification of cell responses to stress. We have determined “functional fingerprints” of sporadic breast cancer-related p53 mutants many of which are also associated with familial cancer proneness such as the Li-Fraumeni Syndrome and germline BRCA1/2 mutant-associated cancers. The ability of p53, wild type and mutants, to transactivate from 11 human target REs has been assessed at variable expression levels using a cellular, isogenomic yeast model system that allows for the rapid analysis of p53 function using a qualitative and a quantitative reporter. Among 50 missense mutants, 29 were classified as loss-of-function. The remaining 21 retained transactivation towards at least one RE. At high levels of galactose induced p53 expression, 12/21 mutants that retain transactivation appeared similar to WT. When the level of galactose was reduced, transactivation defects could be revealed suggesting that some breast cancer related mutants can have subtle changes in transcription. These findings have been compared with clinical data from an ongoing neoadjuvant chemotherapy treatment trial for locally advanced breast tumors. The functional and nonfunctional missense mutations may distinguish tumors in terms of demographics, appearance and relapse, implying that heterogeneity in the functionality of specific p53 mutations could impact clinical behavior and outcome.
The use of Nile Red to monitor the aggregation behavior in ternary surfactant–water–organic solvent systems (2005)

Abstract Ternary systems of surfactants, water and organic solvents were studied by monitoring the steady‐state fluorescence of the versatile solvatochromic probe Nile Red. We found not only that Nile Red can be used throughout the whole isotropic regions in the phase diagram, but also that subtle changes in the aggregation state of the surfactant can be monitored. The formation of inverted micelles in n ‐hexane could be followed upon the addition of small amounts of water, in addition to the formation of normal micelles in water and water–organic solvent mixtures. In aqueous C 12 EO 4 solutions the temperature‐dependent micelle‐to‐vesicle‐to‐inverted micelle transition was visualized by Nile Red fluorescence. Finally, the incorporation of solvent into the micellar interior could also be monitored using Nile Red as the probe. Copyright © 2005 John Wiley &amp; Sons, Ltd.
Seed layer controlled deposition of ZnO films with a tilted c-axis for shear mode resonators (2014)

We investigate different procedures for achieving ZnO films with the c-axis tilted with respect to the normal for their application in acoustic resonators operating in the shear modes. The approach consists in combining the use of textured surfaces of different nature with off-axis sputtering, which promotes the growth of ZnO with inclined microcrystals. The rough surfaces investigated are porous-SiO2 and AlN and ZnO seed layers films specifically prepared to exhibit textured surfaces. The suitability of these films for the intended applications is tested by analyzing the frequency response of ZnO-based solidly mounted resonators. Electromechanical coupling factors for the shear modes up to 3.3% are achieved.
SceneGraphFusion: Incremental 3D Scene Graph Prediction from RGB-D Sequences (2021)

Scene graphs are a compact and explicit representation successfully used in a variety of 2D scene understanding tasks. This work proposes a method to incrementally build up semantic scene graphs from a 3D environment given a sequence of RGB-D frames. To this end, we aggregate PointNet features from primitive scene components by means of a graph neural network. We also propose a novel attention mechanism well suited for partial and missing graph data present in such an incremental reconstruction scenario. Although our proposed method is designed to run on submaps of the scene, we show it also transfers to entire 3D scenes. Experiments show that our approach outperforms 3D scene graph prediction methods by a large margin and its accuracy is on par with other 3D semantic and panoptic segmentation methods while running at 35Hz.
X-Ray Reflectivity Analysis Incorporated with Genetic Algorithm to Analyze the Y- to X Type Transition in CdA LB Film (1998)

The structure and layer distribution of cadmium arachidate Langmuir-Blodgett film were analyzed by the small angle X-ray reflectivity measurements using synchrotron radiation. Y-to X type transition was ocurred during the 39th passage of deposition of cadmium arachidate. Based on the measurement of the consumed area of the monolayer, it was determined that about 27.5 layer was deposited. Using the synchrotron X-ray, the reflectivity profile of cadmium arachidate LB film over the wide range of grazing angle was obtained. The X-ray reflectivity profile was analyzed using the recursion formula. By fitting the location and dispersion of the subsidiary maxima between the Bragg peaks of the measured reflectivity profile with that of the calculated reflectivity profile, the average thickness and the distribution of layer thickness were evaluated. The genetic algorithm was adopted to the fitting of reflectivity profile to evaluate the optimum value of the number distribution of layer. Based on the morphology measurement with an atomic force microscopy (AFM), the domain structure and mean roughness of LB films were obtained. The mean roughness value calculated based on the number of layer distribution obtained from the measurement by AFM is consistent with that obtained from X-ray reflectivity analysis.
Optimizing the violacein biosynthetic pathway using droplet microfluidics (2020)

We have developed a microfluidic platform that uses aqueous droplets suspended in an oil phase as discrete reaction chambers to carry out molecular biology steps. It integrates and automates all critical procedures of synthetic biology including combinatorial gene assembly, transformation by electroporation, addition of selection medium, culture, assay and sorting on a single device.