gebhart/patrepeval huggingface dataset:
miRNA profiles of canine cutaneous mast cell tumours with early nodal metastasis and evaluation as potential biomarkers (2020)

Cutaneous mast cell tumours (MCTs) are common skin neoplasms in dogs. MicroRNAs (miRNAs) are post-transcriptional regulators involved in several cellular processes, and they can function as tumour promoters or suppressors. However, the role of miRNAs in canine MCTs has not yet been elucidated. Thus, the current study aimed to characterize miRNA profiles and to assess their value as biomarkers for MCTs. miRNA expression profiles were assessed in formalin-fixed, paraffin-embedded samples by next-generation sequencing. Ten samples were MCT tissues, and 7 were healthy adjacent tissues. Nine dysregulated miRNAs (DE-miRNAs) were then validated using RT-qPCR in a larger group of MCT samples, allowing the calculation of ROC curves and performance of multiple factor analysis (MFA). Pathway enrichment analysis was performed to investigate miRNA biological functions. The results showed that the expression of 63 miRNAs (18 up- and 45 downregulated) was significantly affected in MCTs. Five DE-miRNAs, namely, miR-21-5p, miR-92a-3p, miR-338, miR-379 and miR-885, were validated by RT-qPCR. The diagnostic accuracy of a panel of 3 DE-miRNAs-miR-21, miR-379 and miR-885-exhibited increased efficiency in discriminating animals with MCTs (AUC = 0.9854) and animals with lymph node metastasis (AUC = 0.8923). Multiple factor analysis revealed clusters based on nodal metastasis. Gene Ontology and KEGG analyses confirmed that the DE-miRNAs were involved in cell proliferation, survival and metastasis pathways. In conclusion, the present study demonstrated that the miRNA expression profile is changed in the MCT microenvironment, suggesting the involvement of the altered miRNAs in the epigenetic regulation of MCTs and identifying miR-21, miR-379 and miR-885 as promising biomarkers.
Modulation index regulation of a multilevel inverter for static var compensation (2004)

A strategy is presented to minimize the voltage total harmonic distortion when controlling a multilevel converter to act as a static var compensator. Use of resultant theory has enabled the complete set of solutions to be found for switching a multilevel inverter's power electronic devices at the fundamental frequency while eliminating the lower order harmonics. A scheme is also presented to regulate the voltage levels of the multilevel inverter so that it operates in an optimum amplitude modulation index regime.
Grundlagen (1990)

Zusammenfassung„Unter einer Menge M verstehen wir jede Zusammenfassung von bestimmten wohlunterschiedenen Objekten m unserer Anschauung oder unseres Denkens (welche die Elemente von M genannt werden) zu einem Ganzen“. So beginnen die 1895 erschienenen „Beiträge zur Begründung der Mengenlehre“ von Georg Cantor. Diese „naive“ Definition soll uns als Ausgangspunkt genügen.
SYNTHESIS OF 5-PHENYL-4,6-DIMETHYL-2-PYRIMIDOL AND DERIVATIVES FROM THE CYCLIZATION OF UREA WITH 3-PHENYL-2,4-PENTANEDIONE (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSYNTHESIS OF 5-PHENYL-4,6-DIMETHYL-2-PYRIMIDOL AND DERIVATIVES FROM THE CYCLIZATION OF UREA WITH 3-PHENYL-2,4-PENTANEDIONECHARLES R. HAUSER and ROBERT M. MANYIKCite this: J. Org. Chem. 1953, 18, 5, 588–593Publication Date (Print):May 1, 1953Publication History Published online1 May 2002Published inissue 1 May 1953https://pubs.acs.org/doi/10.1021/jo01133a016https://doi.org/10.1021/jo01133a016research-articleACS PublicationsRequest reuse permissionsArticle Views398Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Self-healing and self-mendable polymers (2010)

Smart materials with the ability to repair themselves have been the focus of different fields of science and engineering. This mini-review provides an insight into the rapidly expanding area of research into smart materials with self-healing properties and also discusses both chemical (reversible and polymeric) and non-chemical (irreversible and microvascular) systems, with emphasis focused on the recent reports in the field.
Progressively refined deep joint registration segmentation (ProRSeg) of gastrointestinal organs at risk: Application to MRI and cone‐beam CT (2023)

ProRSeg produced more accurate and consistent GI OARs segmentation and DIR of MRI and CBCTs compared to multiple methods. Preliminary results indicates feasibility for OAR dose accumulation using ProRSeg.
Über die Umsetzung von Chlorcyan mit Schwefeltrioxyd (1956)

Abstract Bei der Einwirkung von Schwefeltrioxyd auf Chlorcyan entstehen die bisher nicht beschriebenen Verbindungen CO 3 NClS, CO 6 NClS 2 und C 2 O 3 N 2 Cl 2 S, deren Konstitution sichergestellt wird. Es werden Vorschriften zur laboratoriumsmäßigen Herstellung dieser Verbindungen mitgeteilt und deren Eigenschaften näher beschrieben.
A comparative evaluation of gene set analysis techniques in predictive classification of expression samples (2010)

We demonstrate how some recently developed techniques of set-level gene expression data analysis may be exploited in the context of predictive classification of gene expression samples for the tasks of attribute selection and extraction. With four benchmark gene expression datasets, we empirically test the influence of these method on the predictive accuracy of constructed classification models in a comparative setting. Our results mainly indicate that gene set selection methods (SAM-GS and the global test) can boost the predictive accuracy if used with caution. 1.
Bulk Processing of High-Temperature Superconducting Oxides (1994)

Recent research and development activities related to processing of bulk superconducting oxides are reviewed. Wiring techniques in bismuth and thallium systems are already fairly well developed, allowing critical current densities to meet a required value for application at liquid helium temperature when a certain magnetic field is applied. In yttrium systems, pinning centers have been successfully introduced into the material even at liquid nitrogen temperature as a result of improvements in processing. Some applications utilizing this strong pinning force have been tested. The mechanism for growth of YBa <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Cu <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7-d</inf> from the partially molten state has also gradually been clarified. In all three types of system, it is expected that superconducting wires with high critical current densities at liquid nitrogen temperature will be developed. A recently developed method for growing bulk single crystals is also mentioned briefly.
Substrate Specificity of the Macrolide‐Glycosylating Enzyme Pair DesVII/DesVIII: Opportunities, Limitations, and Mechanistic Hypotheses (2006)

Gemeinsam sind sie stark: DesVII, eine Glycosyltransferase, die bei der Biosynthese von Makrolid-Antibiotika eine Rolle spielt, ist ungewöhnlich, weil sie einen zusätzlichen Proteinpartner, DesVIII, für ihre volle Aktivität benötigt. Das Ausmaß der Substrattoleranz des DesVII/DesVIII-Paars wurde untersucht.
Ex Vivo HIFU Experiments Using a $32 \times 32$ -Element CMUT Array (2016)

High-intensity focused ultrasound (HIFU) has been used as noninvasive treatment for various diseases. For these therapeutic applications, capacitive micromachined ultrasonic transducers (CMUTs) have advantages that make them potentially preferred transducers over traditional piezoelectric transducers. In this paper, we present the design and the fabrication process of an 8 ×8 -mm <sup>2</sup> 32 ×32 -element 2-D CMUT array for HIFU applications. To reduce the system complexity for addressing the 1024 transducer elements, we propose to group the CMUT array elements into eight HIFU channels based on the phase delay from the CMUT element to the targeted focal point. Designed to focus at an 8-mm depth with a 5-MHz exciting frequency, this grouping scheme was realized using a custom application-specific integrated circuit. With a 40-V dc bias and a 60-V peak-to-peak ac excitation, the surface pressure was measured 1.2 MPa peak-to-peak and stayed stable for a long enough time to create a lesion. With this dc and ac voltage combination, the measured peak-to-peak output pressure at the focus was 8.5 MPa, which is expected to generate a lesion in a minute according to the temperature simulation. The following ex vivo tissue experiments successfully demonstrated its capability to make lesions in both bovine muscle and liver tissue.
Perovskite enhanced solid state ZnO solar cells (2013)

This paper will report on the design, fabrication and testing of a solid-state perovskite enhanced ZnO solar cell. The p-type perovskite material used is bismuth ferrite (BFO) which has an absorption range within the blue range of the visible light spectrum. The solid state solar cell, was sensitized with N719 dye and used a CuSCN hole conductor. A disadvantage of ZnO is its poor chemical stability in acidic and corrosive environments. As chemical solution techniques were used in depositing BFO, a buffer method using an aminosilane ((3-aminopropyltrimethoxysilane or H2N(CH2)3Si(OCH3)3)) coating was used to provide a protective coating on the ZnO nanorods before the BFO film was spin coated onto the ZnO nanorods. The photovoltaic performance of the solar cells were tested using a Keithley 2400 source meter under 100mW/cm2, AM 1.5G simulated sunlight, where improvements in Jsc and efficiency were observed. The BFO was able to harness more electrons and also acted as a buffer from electron recombination.
Progression of Aortic Arch Calcification Is Associated with Overall and Cardiovascular Mortality in Hemodialysis (2020)

Progression of AoAC outperformed the baseline AoAC in association with increased risk of overall and CV mortality in HD patients. A regular follow-up of chest radiograph and AoAC score assessments are simple and cost-effective to identify the high-risk individuals of unfavorable outcomes in maintenance HD patients.
Metabolomics and molecular marker analysis to explore pepper (Capsicum sp.) biodiversity (2012)

An overview of the metabolic diversity in ripe fruits of a collection of 32 diverse pepper (Capsicum sp.) accessions was obtained by measuring the composition of both semi-polar and volatile metabolites in fruit pericarp, using untargeted LC-MS and headspace GC-MS platforms, respectively. Accessions represented C. annuum, C. chinense, C. frutescens and C. baccatum species, which were selected based on variation in morphological characters, pungency and geographic origin. Genotypic analysis using AFLP markers confirmed the phylogenetic clustering of accessions according to Capsicum species and separated C. baccatum from the C. annuum-C. chinense-C. frutescens complex. Species-specific clustering was also observed when accessions were grouped based on their semi-polar metabolite profiles. In total 88 semi-polar metabolites could be putatively identified. A large proportion of these metabolites represented conjugates of the main pepper flavonoids (quercetin, apigenin and luteolin) decorated with different sugar groups at different positions along the aglycone. In addition, a large group of acyclic diterpenoid glycosides, called capsianosides, was found to be highly abundant in all C. annuum genotypes. In contrast to the variation in semi-polar metabolites, the variation in volatiles corresponded well to the differences in pungency between the accessions. This was particularly true for branched fatty acid esters present in pungent accessions, which may reflect the activity through the acyl branch of the metabolic pathway leading to capsaicinoids. In addition, large genetic variation was observed for many well-established pepper aroma compounds. These profiling data can be used in breeding programs aimed at improving metabolite-based quality traits such as flavour and health-related metabolites in pepper fruits. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11306-012-0432-6) contains supplementary material, which is available to authorized users.
Chronological trends in trace metals recorded by a tree bark pocket in Yakushima Island, Japan (2005)

Bark included within the trunk of a 200-year-old Japanese cedar tree harvested in Yakushima Island, Japan, a World Natural Heritage Site located 150 km south of mainland Japan and 800 km east of Shanghai, China, was analysed for trace metals by ICP-MS providing a chronology of atmospheric pollution. The concentration of V, As and Pb in decadal sections of the bark pocket increased 30 to 50 fold from 1900-09 to 1960-69, indicating increased atmospheric deposition of these metals. The trend coincided with the establishment and expansion of heavy industries in Kyushu, Japan, resulting in locally high levels of air pollution. V, As and Pb subsequently declined, reflecting lower industrial emissions following air pollution control legislation from the late 1960's and decline in heavy industries. Ni, Cu and Zn showed a relatively small, 7 to 10 fold increase over time. Lead isotope ratios in the bark pockets shifted from about 0.84 to 0.86 for 207Pb/206Pb and from 2.04 to 2.10 for 208Pb/206Pb, showing that the origin of atmospheric lead changed over time from coal to more diverse sources.
Synthesis of Quaternized Amine-Terminated Polyacrylonitrile and Their Antimicrobial Assessment (2014)

Antimicrobial polymers based on polyacrylonitrile (PAN) have been prepared. The cyano groups of the polyacrylonitrile were modified through the reaction with different aliphatic diamines having varied chain lengths. Formation of biocidal polymers (antifungal and antibacterial agents) containing quaternary ammonium salts were then achieved by immobilization of glycidyl trimethyl ammonium chloride (GTMAC) onto the amine-terminated polymers. Antimicrobial activity of the prepared polymers was demonstrated against some selected plant and human pathogenic Gram-negative and Gram-positive bacteria, as well as some pathogenic fungi by the cut plug method and viable cell counting methods. Generally, all polymers showed an increase in the inhibitory action against all the tested microorganisms in comparison with their control.
[Electroacupuncture combined with conduction anesthesia in operations on varicose veins of the lower limbs]. (1985)

A combination of conduction anesthesia and electroacupuncture was used for obtaining an adequate adaptive effect in 22 patients with varicose dilatation of veins. Good sedative effect was obtained in 12 patients, satisfactory--in 6 patients. In 4 patients minimum doses of droperidol were additionally injected. Antinociceptive therapy in corporal and auricle points in the postoperative period permitted exclusion of narcotics in 14 patients, in 8 patients their doses were considerably lower.
Regeneration and Transformation of a Roadside Tree Pittosporum tobira A. (2002)

The regeneration of multiple shoots from hypocotyl sections of Pittosporum tobira was studied on woody plant medium supplemented with differing concentrations of thidiazuron and naphthaleneacetic acid. Maximally 75% of hypocotyl sections formed multiple shoots when using the medium containing 10μM thidiazuron and 3.2μM naphthaleneacetic acid. Multiple shoots were transferred to a shoot-elongation medium followed by transfer to rooting medium. Plantlets formed were acclimatized, and complete plants were regenerated about 10 months after the initiation of the culture. A plasmid vector pANiR, which bears the cDNA of the nitrite reductase (NiR) gene from Arabidopsis thaliana under the control of cauliflower mosaic virus 35S promoter and nopaline synthase terminator, was introduced - together with pCH-bearing hygromycin resistance gene - into hypocotyl sections of Pittosporum tobira using a particle gun. A number of hygromycin-resistant calli were obtained, from which shoots were regenerated. The integration of Arabidopsis NiR cDNA into the genome of Pittosporum tobira was detected by the polymerase chain reaction method, confirming that these shoots were transgenic.
USE OF A MULTIWAVELENGTH UV-VIS DETECTOR WITH HP-GPC TO GIVE A THREE-DIMENSIONAL VIEW OF BITUMINOUS MATERIALS (1989)

High performance gel permeation chromatography (HP-GPC) is being used in the study of asphalt cements. The use of a photodiode array spectrophotometric detector adds to the chemical information that may be obtained from the HP-GPC molecular size distribution by providing chromatograms at multiple wavelengths in the ultraviolet-visible range simultaneously. A three-dimensional image of the asphalt and spectra at various elution times are obtained. The result is improved knowledge of the conjugation/aromaticity of asphalt components of various hydrodynamic volumes. In this study, a group of 19 asphalt cements, from worldwide sources and representing a broad range of properties, was selected for eventual construction of a data base. These materials were sorted into three classes based on their chromatographic shapes. These classes appear to extend to temperature susceptibility (PVN) and aging index as well. Also investigated were a limited number of less common materials to determine the potential utility of the technique. These materials included SARA fractions, viscosity-reduced, air-blown and solvent-deasphalted residua.
ChemInform Abstract: Synthesis and Use of Pseudopeptides Derived from 1,2,4‐Oxadiazole‐, 1,3,4‐Oxadiazole‐, and 1,2,4‐Triazole‐Based Dipeptidomimetics (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Human U2 snRNA Genes Exhibit a Persistently Open Transcriptional State and Promoter Disassembly at Metaphase (2008)

In mammals, small multigene families generate spliceosomal U snRNAs that are nearly as abundant as rRNA. Using the tandemly repeated human U2 genes as a model, we show by footprinting with DNase I and permanganate that nearly all sequences between the enhancer-like distal sequence element and the initiation site are protected during interphase whereas the upstream half of the U2 snRNA coding region is exposed. We also show by chromatin immunoprecipitation that the SNAPc complex, which binds the TATA-like proximal sequence element, is removed at metaphase but remains bound under conditions that induce locus-specific metaphase fragility of the U2 genes, such as loss of CSB, BRCA1, or BRCA2 function, treatment with actinomycin D, or overexpression of the tetrameric p53 C terminus. We propose that the U2 snRNA promoter establishes a persistently open state to facilitate rapid reinitiation and perhaps also to bypass TFIIH-dependent promoter melting; this open state would then be disassembled to allow metaphase chromatin condensation.
Core–shell Au/CeO2 nanoparticles supported in UiO-66 beads exhibiting full CO conversion at 100 °C (2017)

Hybrid core–shell Au/CeO<sub>2</sub> nanoparticles (NPs) dispersed in UiO-66 shaped into microspherical beads are created using the spray-drying continuous-flow method.
Effect of Electron Beam Irradiation and Storage at 5 °C on Thiobarbituric Acid Reactive Substances and Carbonyl Contents in Chicken Breast Meat Infused with Antioxidants and Selected Plant Extracts (2004)

This study evaluated the effectiveness of synthetic and natural antioxidants, green tea, commercial grape seed extracts/combinations, and TBHQ, with varying concentrations of lipid oxidation of nonirradiated and irradiated chicken breast meats stored at 5 degrees C for 12 days. Fresh boneless and skinless chicken breast meats were vacuum-infused with varying concentrations of antioxidants: green tea, grape seed extracts alone/in combination, and TBHQ. The irradiation dosage was 3.0 kGy. Carbonyl values of raw chicken meat and thiobarbituric acid reactive substances (TBARS) values of raw and cooked chicken meat were determined for 0-12 days at 5 degrees C storage. TBARS values for 0-12 days of storage at 5 degrees C ranged from 1.21 to 7.3 and 1.22 to 8.51 mg malondialdehyde/100 g chicken for nonirradiated and irradiated raw chicken, respectively. TBARS values of cooked chicken ranged from 2.19 to 35.83 and 2.45 to 45.72 mg malondialdehyde/100 g chicken for nonirradiated and irradiated chicken, respectively. Irradiation increased TBARS values of both controls and plant extracts. The carbonyl content in meat lipid ranged from 1.7 to 2.9 and 1.7 to 4.41 micromol acetophenone/10 g of nonirradiated and irradiated chicken meat, respectively, and meat protein ranged from 1.4 to 2.07 and 1.41 to 2.72 micromol/10 g meat. Infusion of chicken meat with selected plant extracts is an effective method to minimize lipid oxidation and volatiles developments caused by irradiation.
Contrasting Roles of Cannabidiol as an Insecticide and Rescuing Agent for Ethanol–induced Death in the Tobacco Hornworm Manduca sexta (2019)

Cannabis sativa, also known as marijuana or hemp, produces a non-psychoactive compound cannabidiol (CBD). To investigate the defensive role of CBD, a feeding preference assay was performed with tobacco hornworm Manduca sexta. The larvae clearly show feeding preference towards the Cannabis tissue containing low CBD over high CBD. While the larva avoided the high CBD diet, we investigated detrimental effects of CBD in the insects' diet. Contrasted to the performance on low CBD-infused artificial diet (AD), larvae reared on the high CBD diet suffer significantly reduced growth and increased mortality. Through testing different carriers, we found that the increase of EtOH in the diet is negatively correlated with insect development and behaviors. Notably, CBD treatment significantly improved ethanol-intoxicated larval survival rate by 40% and also improved diet searching activity, resulting in increased diet consumption. Electrophysiology results revealed that the CBD-treated ganglia had delayed but much larger response with electric stimuli in comparison to the larvae reared on AD only and EtOH-added diet. Our results show CBDs' defensive role against pest insects, which suggests its possible use as an insecticide. We also provide evidence that CBD alleviates alcohol-induced stress; consequently, improving the performance and viability of M. sexta larvae.