gebhart/patrepeval huggingface dataset:
Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans (2000)

Ghrelin, a novel GH-releasing acylated peptide, was recently isolated from rat stomach. It stimulated the release of GH from the anterior pituitary through the GH secretagogue receptor (GHS-R). Ghrelin messenger RNA and the peptide are present in rat stomach, but its cellular source has yet to be determined. Using two different antibodies against the N- and C-terminal regions of rat ghrelin, we identified ghrelin-producing cells in the gastrointestinal tracts of rats and humans by light and electron microscopic immunohistochemistry and in situ hybridization combined with immunohistochemistry. Ghrelin-immunoreactive cells, which are not enterochromaffin-like cells, D cells, or enterochromaffin cells, accounted for about 20% of the endocrine cell population in rat and human oxyntic glands. Rat ghrelin was present in round, compact, electron-dense granules compatible with those of X/A-like cells whose hormonal product and physiological functions have not previously been clarified. The localization, population, and ultrastructural features of ghrelin-producing cells (Gr cells) indicate that they are X/A-like cells. Ghrelin also was found in enteric endocrine cells of rats and humans. Using two RIAs for the N- and C-terminal regions of ghrelin, we determined its content in the rat gastrointestinal tract. Rat ghrelin was present from the stomach to the colon, with the highest content being in the gastric fundus. Messenger RNAs of ghrelin and GHS-R also were found in these organs. Ghrelin probably functions not only in the control of GH secretion, but also in the regulation of diverse processes of the digestive system. Our findings provide clues to additional, as yet undefined, physiological functions of this novel gastrointestinal hormone.
Demographic data and clinical characteristics of patients with functional neurological (conversion) disorder (2022)

Background: The causes of emergence of conversion/functional neurological symptoms has been debated since before Freud, but the relationship between trauma and symptoms remains unclear. This study aimed to assess the effect of sociodemographic characteristics and the development of conversion disorder. Methods: We retrospectively reviewed patients who attended Australia’s first functional neurology clinic between 2014 and 2019. We reviewed patients’ medical records, including referral and clinic letters formulating their assessment after interview by two psychiatrists, as well as a clinic questionnaire. Results: There were 106 females, 43 males and five transgender patients. Sensory (51%), motor (47%) and seizures (39%) were the most commonly reported functional symptoms, males and females showed differences in their types of conversion symptoms: females had more gait problems (p=0.004) than males who experienced more impaired consciousness (p=0.006). Females were more prone to childhood sexual abuse (p<0.001) and adult other health issues (p=0.039). Finally, three transgender patients experienced work problems before their illness (p=0.027). Conclusion: Demographic data and clinical characteristics of patients impacted the emergence of conversion disorder
Provably Optimal Control for Multiplicative Amplitude Control Noise (2022)

We provide a technique to obtain provably optimal control sequences for quantum systems under the influence of time-correlated multiplicative control noise. Utilizing the circuit-level noise model introduced in [Phys. Rev. Research 3, 033229(2021)], we show that we can map the problem of finding such a sequence to a convex optimization problem with guaranteed optimality that follows from the convexity. We also show that this technique is compatible with more general off-axis time-correlated dephasing noise. In spite of losing provable optimality, numerically optimized control sequences under this scenario can still achieve nearly optimal performance when the control noise is strong relative to the dephasing contribution. This approach will enable the development of optimal quantum logic gates in systems where noise due to amplitude drifts in the control is strong relative to dephasing such as in ion-trap based quantum computers or in the limit of fast control.
Flow Rates Through Alum Coagulation and Activated Sludge Flocs (2002)

Abstract The liquid velocity inside alum and activated sludge flocs was calculated using the size, settling velocity and permeability of activated sludge flocs. The permeability of activated sludge flocs has been determined experimentally. The permeability of alum coagulation flocs was assumed to be half of the permeability of activated sludge flocs based on the size of the pores in these flocs. The average flow velocity inside an activated sludge floc was calculated to be 1575 µm/s, which is in the range of the flow experimentally measured inside biofilms at a distance of about 100 µm from the substratum by Beer et al. (1995). The flow inside an alum coagulation floc was calculated to be 318 µm/s. The flow velocity inside the same flocs estimated with Davies permeability model were 0.7 µm/s for activated sludge flocs and 20 µm/s for alum coagulation flocs. Therefore, the flow velocities estimated on the basis of experimentally determined permeability were much higher than the velocities calculated with Davies permeability model. Davies permeability model assumes homogeneous distribution of porosity inside an aggregate. Direct observations made during the analysis of floc sections have proven this assumption to be wrong. Flocs have fractal structure and the models predicting their permeability should be based on this feature. Flow rates through alum and activated sludge flocs predicted on the basis of the fractal model of a floc compared well with experimental results.
Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage (2007)

Insulin resistance contributes to the pathophysiology of diabetes and is a hallmark of obesity, metabolic syndrome, and many cardiovascular diseases. Therefore, quantifying insulin sensitivity/resistance in humans and animal models is of great importance for epidemiological studies, clinical and basic science investigations, and eventual use in clinical practice. Direct and indirect methods of varying complexity are currently employed for these purposes. Some methods rely on steady-state analysis of glucose and insulin, whereas others rely on dynamic testing. Each of these methods has distinct advantages and limitations. Thus, optimal choice and employment of a specific method depends on the nature of the studies being performed. Established direct methods for measuring insulin sensitivity in vivo are relatively complex. The hyperinsulinemic euglycemic glucose clamp and the insulin suppression test directly assess insulin-mediated glucose utilization under steady-state conditions that are both labor and time intensive. A slightly less complex indirect method relies on minimal model analysis of a frequently sampled intravenous glucose tolerance test. Finally, simple surrogate indexes for insulin sensitivity/resistance are available (e.g., QUICKI, HOMA, 1/insulin, Matusda index) that are derived from blood insulin and glucose concentrations under fasting conditions (steady state) or after an oral glucose load (dynamic). In particular, the quantitative insulin sensitivity check index (QUICKI) has been validated extensively against the reference standard glucose clamp method. QUICKI is a simple, robust, accurate, reproducible method that appropriately predicts changes in insulin sensitivity after therapeutic interventions as well as the onset of diabetes. In this Frontiers article, we highlight merits, limitations, and appropriate use of current in vivo measures of insulin sensitivity/resistance.
Studies on pyrrolidones. An improved synthesis of N‐arylmethyl pyroglutamic acids (2003)

Abstract Low solubility of the aromatic aldehyde in a water/ethanol medium can prevent the sodium borohydride reductive alkylation of the sodium salt of glutamic acid. In that case, the reductive alkylation can be realized in methanol by using a triethylammonium salt. The uses of 2 molar equivalent of triethylammonium salt of glutamic acid for one molar equivalent of aldehyde strongly raise the yields. Cyclization of the N‐substituted glutamic acids obtained gives then N‐arylmethyl pyroglutamic acids in good yields.
Is It Safer to Intubate Premature Infants in the Delivery Room?: In Reply (2006)

In Reply .—

Dr Kribs underscores the importance of our finding of the need for experience and time to achieve reasonable success with the implementation of early nasal continuous positive airway pressure (ENCPAP) in premature infants.1 Such time is required by the staff to gain enough confidence in the delivery room to proceed with ENCPAP without tracheal intubation. We noticed a significant trend for less intubation in the delivery …
Quercetin Induces Apoptosis in Glioblastoma Cells by Suppressing Axl/IL-6/STAT3 Signaling Pathway (2021)

Gliomas are the mostly observed form of primary brain tumor, and glioblastoma multiforme (GBM) shows the highest incidence. The survival rate of GBM is fairly poor; thus, discovery of effective treatment options is required. Among several suggested targets for therapy, the Axl/IL-6/STAT3 signaling pathway has gained recent interest because of its important role within cancer microenvironment. Quercetin, a plant flavonoid, is well known for its anticancer action. However, the effect of quercetin on Axl has never been reported. Quercetin treatment significantly reduced cell viability in two GBM cell lines of U87MG and U373MG while keeping 85% of normal astrocytes alive. Further western blot assays suggested that quercetin induces apoptosis but does not affect Akt or mitogen-activated protein kinases, factors related to cell proliferation. Quercetin also decreased IL-6 release and phosphorylation of STAT3 in GBM cells. In addition, gene expression, protein expression, and half-life of synthesized Axl protein were all suppressed by quercetin. By applying shRNA for knockdown of Axl, we could confirm that the role of Axl was crucial in the apoptotic effect of quercetin on GBM cells. In conclusion, we suggest quercetin as a potential anticancer agent, which may improve cancer microenvironment of GBM via the Axl/IL-6/STAT3 pathway.
Habitat monitoring with sensor networks (2004)

These networks deliver to ecologists data on localized environmental conditions at the scale of individual organisms to help settle large-scale land-use issues affecting animals, plants, and people.
Standard life (2006)

Daniel Allen fears the days of many health-related charities are numbered
Dipyridylamine Ligands − Synthesis, Coordination Chemistry of the Group 10 Metals and Application of Nickel Complexes in Ethylene Oligomerization (2001)

A great variety of 2,2′-bipyridylamines can be synthesized starting from primary amines or 2-aminopyridines (for instance, symmetrically and unsymmetrically substituted as well as chiral ligands) by palladium-catalyzed aryl amination. The reaction of such ligands with [PdCl2(COD)] or [NiBr2(DME)] (COD = cycloocta-1,5-diene; DME = 1,2-dimethoxyethane) led to the corresponding dichloro or dibromo complexes. The results of X-ray crystal structure analyses of selected compounds show that the ligands coordinate through the two pyridine N-atoms. Their palladium complexes have a slightly distorted planar coordination (in the case of nickel a distorted tetrahedral coordination), with N−M−N angles of 96.0(2)° (M = Ni) and 85.7° (averaged, M = Pd). The nickel complexes are highly active ethylene oligomerization catalysts if activated with Et3Al2Cl3.
Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin (2016)

Intravenous immunoglobulin G (IVIG) is used in the therapy of various autoimmune and inflammatory conditions. The mechanisms by which IVIG exerts anti-inflammatory effects are not completely understood. IVIG interacts with numerous components of the immune system including dendritic cells, macrophages, T and B cells and modulate their functions. Recent studies have reported that heme oxygenase-1 (HO-1) pathway plays an important role in the regulation of inflammatory response in several pathologies. Several therapeutic agents exert anti-inflammatory effects via induction of HO-1. Therefore, we aimed at exploring if anti-inflammatory effects of IVIG are mediated via HO-1 pathway. Confirming the previous reports, we report that IVIG exerts anti-inflammatory effects on innate cells as shown by the inhibitory effects on IL-6 and nitric oxide production and confers protection in experimental autoimmune encephalomyelitis (EAE) model. However, these effects were not associated with an induction of HO-1 either in innate cells such as monocytes, dendritic cells and macrophages or in the kidneys and liver of IVIG-treated EAE mice. Also, inhibition of endogenous HO-1 did not modify anti-inflammatory effects of IVIG. These results thus indicate that IVIG exerts anti-inflammatory effects independent of HO-1 pathway.
A Review Bioactive Components of Vigna mungo (2019)

The bioactive compound is secondary plant metabolites eliciting pharmacological or toxicological effects in man and animals. Legumes are a valuable source of proteins and nutrients for the majority of the world population. Vigna mungo is one of the important legume crops extensively cultivated in India and other parts of the world. Pulses and legumes have been gaining interest because they are an excellent source of bioactive compounds. The objective of this present review is to compile all relevant information published regarding bioactive components from the Vigna mungo. Various bioactive components reported in Vigna mungo were found and it includes flavonoids, isoflavonoids, phytoestrogens, phenolic acids, enzymes, fibers, starches, trypsin inhibitors, phytic acid, lectins, saponins, tocopherols, fatty acids and proteins. This review clearly demonstrates that Vigna mungo is rich in bioactive components and these components are located in various organs of the plant.
Template free fabrication of porous g-C3N4/graphene hybrid with enhanced photocatalytic capability under visible light (2014)

Graphene modified porous g-C3N4 (porous g-C3N4/graphene) with efficient photocatalytic capability under visible light irradiation was fabricated by means of calcinations without extra templates. We expected that the photocatalytic capability of this hybrid photocatalyst could be enhanced by the efficient visible light absorption owing to the porous structure and efficient photogenerated charge separation owing to the heterojunction built between porous g-C3N4 and graphene. Scanning electron microscopy images demonstrated that the as prepared photocatalyst is composed of graphene and porous g-C3N4. The ultraviolet–visible diffuse reflectance spectrum shows that optical absorption for porous g-C3N4/graphene is more intensive than for pristine g-C3N4/g-C3N4/graphene/porous g-C3N4. The enhanced generation of photocurrent under visible light irradiation (λ>400 nm) is observed using the porous g-C3N4/graphene. The results of photocatalytic experiments under visible light irradiation reveal that the pseudo first order kinetic constant of photocatalytic degradation of methylene blue using the porous g-C3N4/graphene is six times as great as that in pristine g-C3N4, showing the advantage of the unique structure in the porous g-C3N4/graphene for efficient photocatalysis.
Expanding the Verrucomicrobial Methanotrophic World: Description of Three Novel Species of Methylacidimicrobium gen. nov (2014)

Methanotrophic Verrucomicrobia have been found in geothermal environments characterized by high temperatures and low pH values. However, it has recently been hypothesized that methanotrophic Verrucomicrobia could be present under a broader range of environmental conditions. Here we describe the isolation and characterization of three new species of mesophilic acidophilic verrucomicrobial methanotrophs from a volcanic soil in Italy. The three new species showed 97% to 98% 16S rRNA gene identity to each other but were related only distantly (89% to 90% on the 16S rRNA level) to the thermophilic genus Methylacidiphilum. We propose the new genus Methylacidimicrobium, including the novel species Methylacidimicrobium fagopyrum, Methylacidimicrobium tartarophylax, and Methylacidimicrobium cyclopophantes. These mesophilic Methylacidimicrobium spp. were more acid tolerant than their thermophilic relatives; the most tolerant species, M. tartarophylax, still grew at pH 0.5. The variation in growth temperature optima (35 to 44°C) and maximum growth rates (µmax; 0.013 to 0.040 h(-1)) suggested that all species were adapted to a specific niche within the geothermal environment. All three species grew autotrophically using the Calvin cycle. The cells of all species contained glycogen particles and electron-dense particles in their cytoplasm as visualized by electron microscopy. In addition, the cells of one of the species (M. fagopyrum) contained intracytoplasmic membrane stacks. The discovery of these three new species and their growth characteristics expands the known diversity of verrucomicrobial methanotrophs and shows that they are present in many more ecosystems than previously assumed.
Characterization, expression and evolution of two novel subfamilies ofPinus monticolacDNAs encoding pathogenesis-related (PR)-10 proteins (2004)

Proteins of the pathogenesis-related (PR)-10 family are induced in many plants by phytopathogens and environmental stresses. A multi-gene family of PR10 proteins has previously been found in the genome of western white pine (Pinus monticola Dougl. ex D. Don). We isolated two novel subfamilies of PR10 cDNAs (PmPR10-2 and PmPR10-3) from P. monticola that are distinct from other PR10 genes (PmPR10-1.1-1.14) reported from the same species. The PmPR10 proteins are grouped in three subfamilies based on similarity in amino acid sequences. The sequence identities of PmPR10 proteins are much higher among members within a subfamily than among members of different subfamilies (86-99% versus 59-68%). Induction of both PmPR10-2 and PmPR10-3 mRNAs was detected by reverse transcriptase-polymerase chain reaction (RT-PCR) in needles in response to wounding treatment. PmPR10-3 was also expressed in needles during cold acclimation in winter. Transcript levels of both PmPR10-2 and PmPR10-3 were less than the detectable levels of constitutive expression in roots, stems and vegetative shoots, whereas PmPR10-1.10 mRNA of subfamily I was expressed at various levels. Phylogenetic analysis showed that PmPR10 and PR10 proteins from other conifers are grouped within one clade that is distinct from that of angiosperm PR10 proteins. In the conifer monophyletic group, PR10 sequences diversify into three distinct clusters. Among these three clusters, some PR10 proteins from single conifer species showed greater divergence distances than sequences from other conifer species, suggesting that, within the conifers, the multi-gene family underwent great diversification during evolution. Based on ratios of nonsynonymous to synonymous nucleotide substitutions (Ka/Ks), we speculate that positive selection resulted in the divergence of PmPR10 subfamilies I and III. Possible mechanisms and significance of PR10 gene evolution are discussed.
Cross-Linked Ionomer Gel Separators for Polysulfide Shuttle Mitigation in Magnesium–Sulfur Batteries: Elucidation of Structure–Property Relationships (2018)

Cross-linked ionomer networks of varying poly- (ethylene glycol) diacrylate cross-linker chain length, ionic comonomer chemistry, and comonomer ratio have been studied for their use as polysulfide shuttle inhibiting separators in magnesium–sulfur (Mg–S) batteries. Through the use of X-ray scattering, polysulfide diffusion experiments, conductivity measurements, and Mg–S cell cycling, it was determined in this work that inclusion of tethered anions in polymer networks mitigates the polysulfide shuttle effect. Polysulfide crossover through networks into a bulk electrolyte can be reduced by absorption into the polymer gel, steric rejection, and electrostatic rejection, with the predominance of these mechanisms dictated by polymer composition and structure. The best network composition allowed an initial Mg–S cell discharge capacity of 522 mAh/g compared to a discharge capacity of 365 mAh/g using a literature standard glass fiber separator. The ionomer cell saw 67% capacity retention after three cycles, whereas the glass fiber separator could not complete the first charging cycle due to the polysulfide shuttle.
Traffic Flow Simulator by Multiagent (2001)

Several methods have been proposed for investigating complex traffic flows. However, the dynamics of vehicles and their drivers' characteristics, which are important factors for any traffic flow analysis, have not been considered sufficiently enough in the past. This paper describes a new concept for simulating complex traffic flows by multiple agents. The agents are considered as a kind of artificial life (A-Life), and their behaviors are independently based on their own knowledge. Drivers, vehicles, roads, and the traffic environment, which are essential elements in our simulation, are defined as the agents. The combination of the driver agent and the vehicle agent work based on the drivers' fields of vision and their unique individual characteristics. The road agent communicates with the vehicle agent in regard to its velocity and position. The effectiveness of our new method for modeling a traffic flow is shown by a simulation study.
Personalized Recommendation in Folksonomies Using a Joint Probabilistic Model of Users, Resources and Tags (2012)

The concept of Web 2.0 or "semantic web" has been getting more and more popular during the last half decade. The potential of very subtle yet important emergent semantics hidden in such environments calls for equally elegant and powerful methods to "mine" them. However, much of the previous work on model based recommender systems for folksonomies considered user to resource and resource to tag similarity separately, ignoring the dependency of users' interest to both the tags and the corresponding resources. In this paper, we propose a probabilistic personalized recommendation model, Latent Interest Model, that accounts for users, tags and resources jointly. The proposed method's performance is evaluated on real data sets obtained from a popular online bookmarking site using different performance measures for tag and resource recommendation tasks. Our experimental results show that our model captures personal preferences for tag usage and resource selection. Performance evaluation of Latent Interest Model indicates that the proposed personalized method yields significant improvement of recommendation accuracy.