gebhart/patrepeval huggingface dataset:
Chiroptical Spectra of 1,2-Cyclopropanedicarboxylic Monothioimides1 (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTChiroptical Spectra of 1,2-Cyclopropanedicarboxylic Monothioimides1, Maria Gdaniec, and Tadeusz PołońskiView Author Information Department of Chemistry, Technical University of Gdañsk, 80-952 Gdańsk, Poland, and Faculty of Chemistry, A. Mickiewicz University, 60-780 Poznań, Poland Cite this: J. Org. Chem. 1997, 62, 6, 1860–1862Publication Date (Web):March 21, 1997Publication History Received9 September 1996Published online21 March 1997Published inissue 1 March 1997https://pubs.acs.org/doi/10.1021/jo961724phttps://doi.org/10.1021/jo961724pbrief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views242Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Absorption,Chirality,Chromophores,Molecular structure,Substituents Get e-Alerts
Overexpression of the Mitochondrial Folate and Glycine–Serine Pathway: A New Determinant of Methotrexate Selectivity in Tumors (2012)

Previous studies have documented the roles of transport via the reduced folate carrier, retention via polyglutamylation, and increased levels of the target enzyme, dihydrofolate reductase in sensitivity to methotrexate. Recent studies have shown that the mitochondrial enzymes in the cellular metabolism of serine, folate, and glycine are overexpressed in a subset of human cancers and that their expression is required for tumor maintenance. In this Perspective article, we propose that the expression of mitochondrial enzymes in the metabolism of serine and glycine, in addition to those involved in folate metabolism, are determinants of the response to methotrexate. Furthermore, we show that myc activation in tumors is associated with upregulation of these enzymes. We propose that patients whose tumors show this phenotype will be sensitive to folate antagonists targeting thymidylate or purine biosynthesis.
The analgesic efficacy of intrathecal d-ala2-d-leu5-enkephalin in cancer patients with chronic pain (1985)

d-Ala-d-Leu-enkephalin (DADL) is a pentapeptide which, compared to morphine, preferentially binds to the delta receptor. We compared the analgesic and side effects of intrathecal (i.t.) DADL and i.t. morphine sulfate (MS) in 10 tolerant cancer patients with chronic pain at or below the T12 level who were receiving inadequate relief or unacceptable side effects from systemic opiates. These patients were given i.t. DADL and i.t. MS in a randomized, double-blind, cross-over study on separate days at least 1 day apart. I.t. DADL produced analgesia in all patients tested. Total pain relief was greater with DADL than MS in 6 patients, equal in 1 patient and less with DADL in 3. Side effects, most commonly drowsiness, were similar with both MS and DADL and suggest supraspinal effects by both drugs. At the doses given i.t. DADL produced effective pain relief in patients tolerant to systemic opiates although no significant difference in analgesic efficacy between MS and DADL was observed. Studies of the relative analgesic potency of i.t. DADL in man are necessary to fully assess its value in those patients tolerant to systemic or i.t. opiates.
Association study ofCREB1 and childhood-onset mood disorders (2005)

Several lines of evidence suggest that the cellular pathways involved in synaptic plasticity contribute to the risk of depression. These findings include the evidence that chronic antidepressant treatment upregulates the cAMP signal transduction cascade resulting in increased expression and function of the cAMP responsive element binding protein (CREB), a transcription factor that increases the expression of key growth factors involved in synaptogenesis and neurogenesis. Recently, linkage to CREB1 was reported for early-onset depression in families recruited from the Pittsburgh area. This finding was significant only in female sibling pairs from those families. Two specific DNA variants, -656G/A and a C insertion/deletion in intron 8, were identified in CREB1 that co-segregated with depression in two of the families. We sought to investigate the relationship of CREB1 to childhood-onset mood disorders (COMD) using a sample of 195 nuclear families (225 affected children) collected in Hungary. We genotyped the two CREB1 DNA variants previously identified as linked to depression as well as three additional polymorphisms spanning the gene. In addition, we genotyped the -656G/A DNA change and the intron 8 polymorphism in a sample of 112 probands with mood disorders collected in the Pittsburgh area and matched controls, and examined the distribution of alleles. The -656A allele was not observed in our samples and there was no evidence for association of the intron 8 polymorphism in either the sample from Pittsburgh (chi(2) = 0.061, 1 d.f., P = 0.803) or Hungary (chi(2) = 0.040, 1 d.f., P = 0.842). We found no evidence for an association with the other three polymorphisms or with the haplotypes of these markers. Further, we found no sex-specific relationship. Our results, therefore, do not support the previous evidence for this gene as a major factor contributing to depression.
The use of Waste Materials in Utility Poles, Crossarms, Paver, and Reef Balls Concrete Structures: Advantages and Care (2013)

Industrial residues such as sludge from water treatment plants (Swtp) from centrifuged method; electrical porcelain residues (Pw); silica fume (Sf 1 and Sf 2 ); tire-rubber waste were evaluated in order to be used in concrete structures of electrical energy and environmental sectors, such as utility poles, crossarms, and reef balls technology. The results showed the necessity for evaluating different recycling concentrations in concrete, concomitantly to physicochemical tests allowing to diagnose natural and accelerated aging.
Semantic confidence calibration for spoken dialog applications (2010)

The success of spoken dialog applications depends strongly on the quality of the semantic confidence measure that determines the selection of the dialog strategy. However, the semantic confidence measure obtained from typical automatic speech recognition engines is not optimized for specific semantic slots and applications. We present our recent work on using a novel maximum entropy model with distribution constraints to calibrate the semantic confidence scores with the inputs of only the raw semantic confidence and the associated raw word confidence scores. We illustrate how features can be constructed from the raw confidence scores with a variable number of words and how the quality of the semantic confidence measure can be further improved by adding another calibration stage for the word confidence measure. We demonstrate the effectiveness of our approach for two types of semantic slots of practical significance. For the ZIP-code semantic slot, the new measure achieves relative 10.6% mean square error (MSE), 19.3% normalized negative log-likelihood (NNLL), and 38.5% equal error rate (EER) reduction. The counterpart of the date-time semantic slot is 37.8%, 38.7%, and 23.1%, respectively.
ChemInform Abstract: Enhanced Densification by Seeding of Sol‐Gel‐Derived Aluminum Titanate. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Figure 2 from Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors (2023)

&lt;p&gt;Mean paclitaxel plasma concentrations following nab-paclitaxel administration alone or with CC-486 in part 1 arm B&lt;/p&gt;
Double-gate MOSFET based reconfigurable cells (2007)

Proposed is a new style of reconfigurable cell using the double-gate MOSFET based on an independent gate control combined with an asymmetric structure. A dynamically reconfigurable 4-function logic cell is used to benchmark the proposal.
Wi-Fi Networks are Underutilized (2009)

We recently learned that Microsoft’s IT department was hesitating to upgrade its Wi-Fi infrastructure to the new, 802.11ncompliant equipment. 802.11n is slated to have 2-4 times the capacity of the currently prevalent 802.11a/g standard.
Serous Otitis Media: Treatment with Injectable Trypsin (1958)

Secretory otitis media has presented problems in its management as evidenced by the reports in medical literature and by our own everyday experience in dealing with this entity. Many cases of secretory otitis media respond to simple management, utilizing a single myringotomy plus politzerization of the Eustachian tube. However, there are many cases which become protracted, requiring multiple myringotomies repeated frequently; they then become chronic cases of secretory otitis media. Therefore time and the problem of management differentiate the acute from the chronic cases. Because management of the chronic cases has posed some problems, suggestions have been made regarding their solution. Hoople et al.<sup>1</sup>recommended politzerization in addition to myringotomy. Autoinflation by the patient has been suggested to maintain drainage through the myringotomy wound. Armstrong<sup>2</sup>has suggested the use of an indwelling polyethylene tube inserted through the membrana tympani, where it is allowed to remain until the condition
Streaming audio classification in Smart Home environments (2011)

In this research, we develop and integrate methods for real-time streaming audio classification based on psychoacoustic models of hearing as well as techniques in pattern recognition. Specifically, a framework for auditory event detection and signal description by means of computer vision approach has been designed to enable real-time processing and classification of audio signals present in home environments. Local binary patterns are employed to describe the extracted sound blobs in the spectrogram. Experimental results show that the proposed approach is quite effective, achieving an overall recognition rate of 80–90% for 8 types of audio input. The performance degrades only slightly in the presence of noise and other interferences.
Self-Organising Stochastic Encoders (2010)

The processing of mega-dimensional data, such as images, scales linearly with image size only if fixed size processing windows are used. It would be very useful to be able to automate the process of sizing and interconnecting the processing windows. A stochastic encoder that is an extension of the standard Linde-Buzo-Gray vector quantiser, called a stochastic vector quantiser (SVQ), includes this required behaviour amongst its emergent properties, because it automatically splits the input space into statistically independent subspaces, which it then separately encodes. Various optimal SVQs have been obtained, both analytically and numerically. Analytic solutions which demonstrate how the input space is split into independent subspaces may be obtained when an SVQ is used to encode data that lives on a 2-torus (e.g. the superposition of a pair of uncorrelated sinusoids). Many numerical solutions have also been obtained, using both SVQs and chains of linked SVQs: (1) images of multiple independent targets (encoders for single targets emerge), (2) images of multiple correlated targets (various types of encoder for single and multiple targets emerge), (3) superpositions of various waveforms (encoders for the separate waveforms emerge - this is a type of independent component analysis (ICA)), (4) maternal and foetal ECGs (another example of ICA), (5) images of textures (orientation maps and dominance stripes emerge). Overall, SVQs exhibit a rich variety of self-organising behaviour, which effectively discovers the internal structure of the training data. This should have an immediate impact on "intelligent" computation, because it reduces the need for expert human intervention in the design of data processing algorithms.
Abstract A027: A phase I open-label, non-randomized study of recombinant compound interferon (rSIFN-co) in patients with advanced solid tumors (2016)

Abstract Background: Recombinant compound interferon (rSIFN-co) is a new class of interferon derived from altering the spatial structure and configuration of the basic interferon protein. rSIFN-co displayed greater anti-tumor activity in solid tumors compared to interferon α-2b in pre-clinical studies. Methods: Patients with advanced malignancies were enrolled to determine the safety, tolerability, recommended phase II dose (RP2D), pharmacodynamics (PD) and preliminary anti-tumor activities in a 3+3 dose escalation design. Two pre-defined dose levels were planned. rSIFN-co was dosed 3 times a week via subcutaneous injection for 21 days followed by 7 days rest. This was preceded by a lead in phase. PD studies comprised of FDG-PET, pre- and post treatment changes in plasma cytokine profile and tumor repressive/ enhancing genes as well as 2'5'-oligoadenylate synthetase levels. Results: Results presented are based on preliminary data collected as of Jan. 27, 2015. 22 patients (median age 65.5 years, 14 male and 8 female) have been enrolled with 21 evaluable for safety and 15 amenable to efficacy analysis. 10 hepatocellular carcinoma (HCC), 6 non-small cell lung cancer (NSCLC), 4 colorectal cancer (CRC), 1 melanoma and 1 nasopharyngeal carcinoma patients (pts) were dosed at 2 dose levels. The RP2D was 24μg 3x/week for 21days followed by 7 days rest. No dose limiting toxicities were encountered. Most adverse events (92%) were CTCAE grade 1 and 2. The most frequent grade 1/2 treatment related adverse events (trAEs) were flu-like symptoms (90%), anorexia (33%), fatigue (33%), weight loss (33%), nausea (29%), thrombocytopenia (29%), and diarrhea (24%). Grade 3/4 trAEs were fever (2 pts), leucopenia (2 pts), transaminitis (2 pts), weight loss (1 pt), fatigue (1 pt), afebrile neutropenia (1 pt) and syncope (1 pt). 11 patients had stable disease (SD) and 4 patients had progressive disease (PD). 4 patients (2 HCC, 1 NSCLC and 1 CRC) had prolonged stable disease (&amp;gt;16 weeks). Detailed PD data will be presented for all cohorts. Conclusion: The RP2D was 24μg three times a week for 21days followed by 7 days rest with a lead in phase. Modest activity was seen in heavily pre-treated advanced solid tumor patients. Citation Format: Su Pin Choo, Wai Meng Tai, Maria Macapagal, Aziah Ahmad, Greg Li, Mui Leng Goh, Matthew Ng, Tira Tan, Shao Weng Tan, Wan Teck Lim. A phase I open-label, non-randomized study of recombinant compound interferon (rSIFN-co) in patients with advanced solid tumors. [abstract]. In: Proceedings of the CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(1 Suppl):Abstract nr A027.
The impact of atmospheric infrared sounder (AIRS) profiles on short-term weather forecasts (2007)

The Atmospheric Infrared Sounder (AIRS), together with the Advanced Microwave Sounding Unit (AMSU), represents one of the most advanced space-based atmospheric sounding systems. Aside from monitoring changes in Earth's climate, one of the objectives of AIRS is to provide sounding information with sufficient accuracy such that the assimilation of the new observations, especially in data sparse regions, will lead to an improvement in weather forecasts. The combined AIRS/AMSU system provides radiance measurements used as input to a sophisticated retrieval scheme which has been shown to produce temperature profiles with an accuracy of 1 K over 1 km layers and humidity profiles with accuracy of 10-15% in 2 km layers in both clear and partly cloudy conditions. The retrieval algorithm also provides estimates of the accuracy of the retrieved values at each pressure level, allowing the user to select profiles based on the required error tolerances of the application. The purpose of this paper is to describe a procedure to optimally assimilate high-resolution AIRS profile data in a regional analysis/forecast model. The paper focuses on a U.S. East-Coast cyclone from November 2005. Temperature and moisture profiles-containing information about the quality of each temperature layer-from the prototype version 5.0 Earth Observing System (EOS) science team retrieval algorithm are used in this study. The quality indicators are used to select the highest quality temperature and moisture data for each profile location and pressure level. AIRS data are assimilated into the Weather Research and Forecasting (WRF) numerical weather prediction model using the Advanced Regional Prediction System (ARPS) Data Analysis System (ADAS), to produce near-real-time regional weather forecasts over the continental U.S. The preliminary assessment of the impact of the AIRS profiles will focus on intelligent use of the quality indicators, analysis impact, and forecast verification against rawinsondes and precipitation data.
En bloc pelvic resection for advanced ovarian cancer preceded by central ligation of vessels supplying the tumor bed: a description of surgical technique and a feasibility study (2016)

Performing a central ligation of vessels supplying the tumor bed prior to an en bloc pelvic resection is feasible with acceptable morbidity and mortality rates.
Intraoperative Assessment of the Resection Specimen Facilitates Achievement of Adequate Margins in Oral Carcinoma (2020)

Specimen-driven intraoperative assessment improves resection margins and consequently, the outcome of oral cancer patients. We advocate this method as standard of care.
Blind Adaptive Constrained Constant-Modulus Reduced-Rank Interference Suppression Algorithms Based on Interpolation and Switched Decimation (2010)

This work proposes a blind adaptive reduced-rank scheme and constrained constant-modulus (CCM) adaptive algorithms for interference suppression in wireless communications systems. The proposed scheme and algorithms are based on a two-stage processing framework that consists of a transformation matrix that performs dimensionality reduction followed by a reduced-rank estimator. The complex structure of the transformation matrix of existing methods motivates the development of a blind adaptive reduced-rank constrained (BARC) scheme along with a low-complexity reduced-rank decomposition. The proposed BARC scheme and a reduced-rank decomposition based on the concept of joint interpolation, switched decimation and reduced-rank estimation subject to a set of constraints are then detailed. The proposed set of constraints ensures that the multipath components of the channel are combined prior to dimensionality reduction. We develop low-complexity joint interpolation and decimation techniques, stochastic gradient, and recursive least squares reduced-rank estimation algorithms. A model-order selection algorithm for adjusting the length of the estimators is devised along with techniques for determining the required number of switching branches to attain a predefined performance. An analysis of the convergence properties and issues of the proposed optimization and algorithms is carried out, and the key features of the optimization problem are discussed. We consider the application of the proposed algorithms to interference suppression in DS-CDMA systems. The results show that the proposed algorithms outperform the best known reduced-rank schemes, while requiring lower complexity.
Recursive Reasoning With Reduced Complexity and Intermittency for Nonequilibrium Learning in Stochastic Games (2022)

In this article, we propose a computationally and communicationally efficient approach for decision-making in nonequilibrium stochastic games. In particular, due to the inherent complexity of computing Nash equilibria, as well as the innate tendency of agents to choose nonequilibrium strategies, we construct two models of bounded rationality based on recursive reasoning. In the first model, named level- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$k$ </tex-math></inline-formula> thinking, each agent assumes that everyone else has a cognitive level immediately lower than theirs and—given such an assumption—chooses their policy to be a best response to them. In the second model, named cognitive hierarchy, each agent conjectures that the rest of the agents have a cognitive level that is lower than theirs, but follows a distribution instead of being deterministic. To explicitly compute the boundedly rational policies, a level-recursive algorithm and a level-paralleled algorithm are constructed, where the latter one can have an overall reduced computational complexity. To further reduce the complexity in the communication layer, modifications of the proposed nonequilibrium strategies are presented, which do not require the action of a boundedly rational agent to be updated at each step of the stochastic game. Simulations are performed that demonstrate our results.
Changes in microflora during oven-drying of culinary herbs (1988)

SummaryChange in bacterial numbers was investigated during the oven-drying of 12 culinary herbs. Two trials were undertaken at different stages in the season of 1986, bacterial numbers were estimated for the freshly harvested herbs prior to drying and at intervals up to 48 hours in the oven.
Evaluation of posttransplantation soluble CD30 for diagnosis of acute renal allograft rejection1 (2003)

sCD30 measured on posttransplantation days 3 to 5 offers a noninvasive means for differentiating patients with impending acute allograft rejection from patients with an uncomplicated course or with acute tubular necrosis.