gebhart/patrepeval huggingface dataset:
Candida albicans Hap43 Is a Repressor Induced under Low-Iron Conditions and Is Essential for Iron-Responsive Transcriptional Regulation and Virulence (2010)

Candida albicans is an opportunistic fungal pathogen that exists as normal flora in healthy human bodies but causes life-threatening infections in immunocompromised patients. In addition to innate and adaptive immunities, hosts also resist microbial infections by developing a mechanism of "natural resistance" that maintains a low level of free iron to restrict the growth of invading pathogens. C. albicans must overcome this iron-deprived environment to cause infections. There are three types of iron-responsive transcriptional regulators in fungi; Aft1/Aft2 activators in yeast, GATA-type repressors in many fungi, and HapX/Php4 in Schizosaccharomyces pombe and Aspergillus species. In this study, we characterized the iron-responsive regulator Hap43, which is the C. albicans homolog of HapX/Php4 and is repressed by the GATA-type repressor Sfu1 under iron-sufficient conditions. We provide evidence that Hap43 is essential for the growth of C. albicans under low-iron conditions and for C. albicans virulence in a mouse model of infection. Hap43 was not required for iron acquisition under low-iron conditions. Instead, it was responsible for repression of genes that encode iron-dependent proteins involved in mitochondrial respiration and iron-sulfur cluster assembly. We also demonstrated that Hap43 executes its function by becoming a transcriptional repressor and accumulating in the nucleus in response to iron deprivation. Finally, we found a connection between Hap43 and the global corepressor Tup1 in low-iron-induced flavinogenesis. Taken together, our data suggest a complex interplay among Hap43, Sfu1, and Tup1 to coordinately regulate iron acquisition, iron utilization, and other iron-responsive metabolic activities.
The oral care of HIV positive patients at Berlin clinic. (1992)

Two final year dental students spent an elective period in the HIV clinic of the Dental Hospital of the Freie University of Berlin. The oral manifestations and management of 50 HIV patients were observed.
Synthesis of Postulated Molecular Probes: Stereoselective Free‐Radical‐Mediated C‐Glycosylation in Tandem with Hydrogen Transfer. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Transformations for the synthesis and optimization of asynchronous distributed control (2002)

Asynchronous design has been the focus of renewed interest. However, a key bottleneck is the lack of high-quality CAD tools for the synthesis of large-scale systems which also allow design-space exploration. This paper proposes a new synthesis method to address this issue, based on transformations.
Surface Structure Dependence of the Dry Dehydrogenation of Alcohols on Cu(111) and Cu(110) (2017)

The non-oxidative dehydrogenation of alcohols is considered as an important method to produce aldehydes for the chemical industry and hydrogen gas. However, current industrial processes are oxidative, meaning that the aldehydes are formed along with water, which, in addition to being less energy efficient, poses separation problems. Herein the production of aldehydes from methanol and ethanol on clean and dry Cu(111) and Cu(110) surfaces was investigated in order to understand the catalytic anhydrous dehydrogenation of alcohols. Both ethanol and methanol preferentially react under ultrahigh vacuum conditions at surface defects to yield acetaldehyde and formaldehyde, respectively, in the absence of surface oxygen and water. The amount of alkoxide reaction intermediates measured by scanning tunneling microscopy, and aldehyde and hydrogen products detected by temperature programmed reaction, are increased by inducing more defects in the Cu substrates with Ar ion sputtering. This work also reveals that the Cu model surfaces are not poisoned by the reaction and exhibit 100% selectivity for alcohol dehydrogenation to aldehyde and hydrogen.
Optical Properties of Secondary Organic Aerosol Produced by Photooxidation of Naphthalene under NOx Condition (2022)

Secondary organic aerosols (SOAs) affect incoming solar radiation by interacting with light at ultraviolet and visible wavelength ranges. However, the relationship between the chemical composition and optical properties of SOA is still not well understood. In this study, the complex refractive index (RI) of SOA produced from OH oxidation of naphthalene in the presence of nitrogen oxides (NOx) was retrieved online in the wavelength range of 315-650 nm and the bulk chemical composition of the SOA was characterized by an online high-resolution time-of-flight mass spectrometer. In addition, the molecular-level composition of brown carbon chromophores was determined using high-performance liquid chromatography coupled to a photodiode array detector and a high-resolution mass spectrometer. The real part of the RI of the SOA increases with both the NOx/naphthalene ratio and aging time, likely due to the increased mean polarizability and decreased molecular weight due to fragmentation. Highly absorbing nitroaromatics (e.g., C<sub>6</sub>H<sub>5</sub>NO<sub>4</sub>, C<sub>7</sub>H<sub>7</sub>NO<sub>4</sub>, C<sub>7</sub>H<sub>5</sub>NO<sub>5</sub>, C<sub>8</sub>H<sub>5</sub>NO<sub>5</sub>) produced under higher NOx conditions contribute significantly to the light absorption of the SOA. The imaginary part of the RI linearly increases with the NOx/VOCs ratio due to the formation of nitroaromatic compounds. As a function of aging, the imaginary RI increases with the O/C ratio (slope = 0.024), mainly attributed to the achieved higher NOx/VOCs ratio, which favors the formation of light-absorbing nitroaromatics. The light-absorbing enhancement is not as significant with extensive aging as it is under a lower aging time due to the opening of aromatic rings by reactions.
Determination of dissociation constants of acids and bases by potentiostatic titration (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of dissociation constants of acids and bases by potentiostatic titrationJouko J. KankareCite this: Anal. Chem. 1972, 44, 14, 2376–2379Publication Date (Print):December 1, 1972Publication History Published online1 May 2002Published inissue 1 December 1972https://pubs.acs.org/doi/10.1021/ac60322a018https://doi.org/10.1021/ac60322a018research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Detecting breathing route during sleep in children using acoustic signal from the nose (2016)

[Confidential, not for public use until the week before the conference date (as written in the Terms of Use Agreement).] Oral breathing is a real problem in pediatric population, which could cause respiratory or orthodontic disorders. Early diagnosis allows proper intervention (in most cases ENT or orthodontic treatment), however it is usually studied through surveys with parents, which are not sufficiently reliable. The aim of the work was to assess the accuracy of distinguishing nasal and oral breathing using the system (Clebre) consisting of wireless acoustic sensor and the mobile application, which utilizes artificial neural networks as a classifier. We proposed the solution to put the Clebre prototype on nose, and stream audio signal from the nasal cavity to the smartphone using Bluetooth. Online algorithm performed episode segmentation and machine learning classification into nasal and oral breathing. 90-seconds-lasting recordings, both for nasal and oral breathing were registered from 50 generally healthy students. The database of the parameters were divided in half into training and testing parts, and automatically labelled. We also tested individual classifier after calibration. We obtained overall accuracy of 93.92% (sensitivity 92.94% and specificity 94.77%) in determining between nasal and oral route. Using individual calibration allows to improve the accuracy to 95.76%. We noticed weak signal when breathing through the mouth, which can be a problem during ambulatory testing. Provided innovative system allows to carry out sleep testing during night to differentiate nasal and oral breathing with high accuracy and more comfortable way than when using nasal cannula or thermistors.
Different behaviors of metallocene and Ziegler–Natta catalysts in ethylene/1,5‐hexadiene copolymerization (2018)

Abstract The behaviors of three different catalyst systems, TiCl 4 /MgCl 2 , Cp 2 ZrCl 2 and Cp 2 HfCl 2 , were investigated in ethylene/1,5‐hexadiene copolymerization. In the Fourier transform infrared spectra of the copolymers, cyclization and branching were detected for 1,5‐hexadiene insertion in the metallocene and Ziegler–Natta systems, respectively. DSC and viscometry analyses results revealed that copolymers with lower T m and crystallinity and higher molecular weight were obtained with metallocene catalysts. The sequence length distribution of the copolymers was investigated by using the successive self‐nucleation and annealing thermal fractionation technique. The continuous melting endotherms obtained from successive self‐nucleation and annealing analysis were employed to get information about short‐chain branching, the branching dispersity index, comonomer content and lamella thickness in the synthesized copolymers. The results established that metallocene catalysts were much more effective than Ziegler–Natta catalysts in the incorporation of 1,5‐hexadiene in the polyethylene structure. Metallocene‐based copolymers had higher short‐chain branching and comonomer content, narrower branching dispersity index and thinner lamellae. Finally, the tendency of the employed catalysts in the 1,5‐hexadiene incorporation and cyclization reaction was explored via molecular simulation. The energy results demonstrated that, in comparison to Ziegler–Natta, metallocene catalysts have a much higher tendency to 1,5‐hexadiene incorporation and cyclization. © 2018 Society of Chemical Industry
An experimental link between the carbon-13 NMR chemical shift of carbonyl carbons and the energy shifts observed in the n .fwdarw. 3s optical transition of cyclic ketones (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn experimental link between the carbon-13 NMR chemical shift of carbonyl carbons and the energy shifts observed in the n .fwdarw. 3s optical transition of cyclic ketonesTimothy J. Cornish and Tomas. BaerCite this: J. Am. Chem. Soc. 1988, 110, 19, 6287–6291Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/ja00227a001https://doi.org/10.1021/ja00227a001research-articleACS PublicationsRequest reuse permissionsArticle Views99Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Learning to Rank Music Tracks Using Triplet Loss (2020)

Most music streaming services rely on automatic recommendation algorithms to exploit their large music catalogs. These algorithms aim at retrieving a ranked list of music tracks based on their similarity with a target music track. In this work, we propose a method for direct recommendation based on the audio content without explicitly tagging the music tracks. To that aim, we propose several strategies to perform triplet mining from ranked lists. We train a Convolutional Neural Network to learn the similarity via triplet loss. These different strategies are compared and validated on a large-scale experiment against an auto-tagging based approach. The results obtained highlight the efficiency of our system, especially when associated with an Auto-pooling layer.
Passive coherent combining of fiber oscillators (2007)

Passive combining of fiber oscillators may one day lead to a simple power scaling capability that multiplies the best results obtained by single devices. Along with HRL's unique approach and early experimental demonstrations, some extensive modeling is underway to sort through the current controversies in this area, to design for large numbers of fibers, and to create the most stable inphase beam output.
Towards semantic methodologies for automatic regulatory compliance support (2011)

Businesses and organizations must comply with requirements and expectations such as regulations, policies, mandates and guidelines to meet public standards and avoid hefty penalties. Checking compliance manually is a laborious, extensive and error-prone process. The problems in the process are, to some extent, alleviated by using computerized compliance management systems. However, these systems are experiencing challenges in coping with the frequent changes and updates in the regulations. This paper describes our research on the use of semantic web technologies to support compliance management. In particular, we propose a methodology, RegCMatic that supports the management of the compliance system. Its originality lies on automating the extraction of regulatory information from regulatory texts, and mapping regulations to organizational internal processes. Our proposed methodology is applied to the Pharmaceutical industry, where regulatory information is extracted from the Eudralex EU regulation and modeled using a semantic formalism.
Facile Conversion of Spirostan Saponin into Furostan Saponin:  Synthesis of Methyl Protodioscin and Its 26-Thio-analogue (2006)

[reaction: see text] A facile approach for the conversion of a spirostan saponin into its furostan counterpart, as illustrated by the transformation of dioscin to methyl protodioscin (and its 26-thio-analogue), has been developed.
Day case paediatric tonsillectomy: a review of three years experience in a dedicated day case unit (1999)

Tonsillectomy is one of the most common surgical procedures performed in children. Day case tonsillectomy is common in many parts of the USA but remains controversial in the UK. Day case tonsillectomy in children has been performed in a dedicated paediatric day care unit at the May day Hospital since 1994. The results for the years 1995-1997 were reviewed. In these years 928 true day case tonsillectomies were performed. Reactionary haemorrhage occurred in 0.97% (nine children) but only three children required a return to theatre. All bleeding occurred within the standard observation period. There were no deaths. The overall effective day case rate was 95.7%, only 31 children needing unplanned admission, mainly for postoperative vomiting. The results suggest that day case tonsillectomy can be safely and successfully performed, with a dedicated paediatric day case unit and a favourable population geography.
Photolyse von 3‐Methyl‐5,5‐diphenyl‐3,5‐dihydro‐4H‐1,2,3‐triazol‐4‐on (1992)

Abstract Photolysis of 3‐Methyl‐5,5‐diphenyl‐3,5‐dihydro‐4 H ‐1,2,3‐triazol‐4‐one [1] Irradiation (λ, ≥ 280 nm) of a degassed solution in deuterated benzene of the dihydro‐1,2,3‐triazolone 5 yields the dihydroindolone 7 , the imine 9 , and its photoreduction product 10 , besides molecular nitrogen.
Design and Evaluation of an Energy Agile Computing Cluster (2012)

A cDNA encoding tomato fruit lectin was cloned from an unripe cherry-tomato fruit cDNA library. The isolated lectin cDNA contained an open reading frame encoding 365 amino acids, including peptides that were sequenced. The deduced sequence consisted of three distinct domains: (i) an N-terminal short extensin-like domain; (ii) a Cys-rich carbohydrate binding domain composed of four almost identical chitin-binding domains; (iii) an internal extensin-like domain of 101 residues containing 15 SerPro(4) motifs inserted between the first and second chitin-binding domains. The molecular weight of the lectin was 65,633 and that of the deglycosylated lectin was 32,948, as determined by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS). This correlated with the estimated molecular weight of the deduced sequence. Recombinant tomato lectin expressed in Pichia pastoris possessed chitin-binding but not hemagglutinating activity. These findings confirmed that the cDNA encoded tomato lectin.
Lack of adaptation to a new host in a generalist herbivore: implications for host plant resistance to twospotted spider mites in cotton (2014)

This 'negative adaptation' indicates robust antibiosis traits in G. arboreum accession BM13H, which therefore have value in developing mite-resistant G. hirsutum cultivars.
Chemie in Mikrostrukturreaktoren (2004)

Abstract Mikrostrukturreaktoren haben in den letzten Jahren in der chemischen Verfahrenstechnik deutlich an Bedeutung gewonnen: Erste Firmen, die Prozessanlagen mit Mikrostrukturreaktoren anbieten, sind am Markt, eine Reihe von Instituten erforscht dieses Gebiet, Universitäten bieten Lehrveranstaltungen an, und einige verfahrenstechnisch orientierte Übersichtsartikel liegen bereits vor. Mikrostrukturierte Systeme sind besonders wertvoll für die Untersuchung stark exothermer schneller Reaktionen. Durch isotherme Betriebsweise lassen sich viele thermisch induzierte Nebenreaktionen zurückdrängen, was sicherheitstechnische Vorteile bei Reaktionen mit gefährlichen Reaktanten bringt. Obwohl viele organische Synthesen mit besseren Ergebnissen als in konventionellen Reaktoren durchgeführt wurden, ist der Mikrostrukturreaktor‐Technologie der große Durchbruch in der präparativen Chemie noch nicht gelungen. Aus diesem Grund unterstreicht dieser Aufsatz die Vorteile von Mikrostrukturreaktoren bei Flüssigphasen‐, Gasphasen‐ und Gas‐Flüssigphasen‐Reaktionen.
Wide-band Raman Stokes and anti-Stokes comb lasing in a BaF2 single crystal under picosecond pumping (2008)

We report on the first observation of stimulated Raman scattering (SRS) in a crystal of cubic BaF 2 . All registered Stokes and anti-Stokes lasing sidebands in the visible and near-IR (up to the 41st order) are identified to the single χ (3) -promoting vibration mode (ω SRS ≈ 238 cm -1 ) of the crystal. The recorded very broad nonlinear lasing comb (more than one octave spanning) in BaF 2 opens the possibility for experiments on femtosecond waveform synthesis and other laser comb applications.
Daily Mental Stress Prediction Using Heart Rate Variability (2018)

In this work, an accurate ECG-based daily mental stress level prediction strategy is presented. Multiple support vector machines (SVM) with linear kernel functions are individually trained to predict daily stress levels of women who participated in the OMsignal MyHeart project. In this study, participants are asked to answer a daily survey to determine the quality of their sleep, exercise, valence, control and rumination during the last 24-hour. Using the aforementioned items, a daily stress score was defined to be used as the target value for constructing the stress prediction model. The model is designed to use heart rate variability (HRV) metrics calculated from a 5- minute data window moving over daily ECG recordings. The features including the first five minimum and maximum values of standard deviation of the NN-intervals (SDNN) and root mean square of the successive differences between normal heart beats (RMSSD) as well as heart rate are extracted to represent each individual daily ECG record. The leave-one-out cross-validation method is used to train and validate our user-dependent SVM model. On validation data, an average accuracy of 82.25% is achieved for predicting daily stress scores of the users with sufficient number of daily survey data.
Sacituzumab govitecan, a novel, third-generation, antibody-drug conjugate (ADC) for cancer therapy (2020)

The properties and clinical results of third-generation ADCs, based on sacituzumab govitecan, are discussed, including prospects for future applications, particularly combination therapies with PARP inhibitors and immune checkpoint inhibitors. Since one topoisomerase I ADC has just received regulatory approval for HER2<sup>+</sup> breast cancer, and sacituzumab govitecan is under FDA review for accelerated approval in the therapy of triple-negative breast cancer, the prospects for these novel ADCs are discussed.
Determination of adsorption equilibria in pores by molecular dynamics in a unit cell with imaginary gas phase (1997)

We developed a new molecular dynamics (MD) scheme, introducing the concept of the potential buffering field through which an adsorbed phase could interact with an imaginary gas phase. This simulation cell allowed us to conduct a MD simulation that allowed a change in the number of molecules to attain equilibrium with given equilibrium pressure, like a grand canonical Monte Carlo simulation. By taking another choice for the setting of the cell, the number of molecules stayed constant but the equilibrium pressure was able to be obtained easily by a new technique of “particle counting method.” The thus obtained equilibrium vapor-phase pressure agreed with that obtained by Widom’s particle insertion method. Some adsorption simulations within slitlike pores of 2 and 3 nm were carried out. Adsorption phenomena could be observed from monolayer adsorption on a pore wall under a low relative pressure to the capillary condensation under a high relative pressure. Thus the adsorption equilibrium relation could be determined. The critical relative pressure for capillary condensation was smaller than that predicted by the modified Kelvin equation. This MD method shall provide much benefit in studying interfaces, which is important for analyzing condensation in pores.
Thymidylate Synthase in Advanced Gastrointestinal and Breast Cancers (1996)

Knowledge of population thymidylate synthase (TS) levels in malignant tumors and normal tissues is essential for the use of TS as a predictor for 5-fluorouracil treatment. Tumor tissue TS levels in fresh frozen surgical biopsies from 136 patients with gastrointestinal or breast cancer, not previously subjected to chemotherapy, were analysed by [3H]FdUMP radioligand binding assay. TS levels were 2.4 +/- 0.31 pmol/g in liver metastases of colorectal cancer (n = 87), 4.2 +/- 1.0 pmol/g in primary colorectal cancer (n = 13), 2.7 +/- 0.93 pmol/g in gastric cancer (n = 13), 3.1 +/- 1.7 pmol/g in pancreatic cancer (n = 10), 3.4 +/- 1.4 pmol/g in breast cancer (n = 13) and 0.58 +/- 0.075 pmol/g in normal liver parenchyma (n = 24). TS levels were significantly higher in malignant tumor tissues compared to normal liver parenchyma.