gebhart/patrepeval huggingface dataset:
Chemical modification of Ca2+-ATPase from sarcoplasmic reticulum with phenylglyoxal (1994)

Conference Article| August 01 1994 Chemical modification of Ca2+-ATPase from sarcoplasmic reticulum with phenylglyoxal SENENA CORBALAN-GARCIA; SENENA CORBALAN-GARCIA 1Departamento de Bioquímica y Biología Molecular A, Facultad de Veterinaria, Universidad de Murcia, Apdo.4021, E-30071 Murcia, Spain Search for other works by this author on: This Site PubMed Google Scholar JOSE A. TERUEL; JOSE A. TERUEL 1Departamento de Bioquímica y Biología Molecular A, Facultad de Veterinaria, Universidad de Murcia, Apdo.4021, E-30071 Murcia, Spain Search for other works by this author on: This Site PubMed Google Scholar JUAN C. GOMEZ-FERNANDEZ JUAN C. GOMEZ-FERNANDEZ 1Departamento de Bioquímica y Biología Molecular A, Facultad de Veterinaria, Universidad de Murcia, Apdo.4021, E-30071 Murcia, Spain Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1994) 22 (3): 381S. https://doi.org/10.1042/bst022381s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation SENENA CORBALAN-GARCIA, JOSE A. TERUEL, JUAN C. GOMEZ-FERNANDEZ; Chemical modification of Ca2+-ATPase from sarcoplasmic reticulum with phenylglyoxal. Biochem Soc Trans 1 August 1994; 22 (3): 381S. doi: https://doi.org/10.1042/bst022381s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1994 Biochemical Society1994 Article PDF first page preview Close Modal You do not currently have access to this content.
The Cathepsin B Death Pathway Contributes to TNF Plus IFN-γ-Mediated Human Endothelial Injury (2005)

Vascular endothelial cells are primary targets of cytokine-induced cell death leading to tissue injury. We previously reported that TNF in combination with LY294002, a PI3K inhibitor, activates caspase-independent cell death initiated by cathepsin B (Cat B) in HUVEC. We report that TNF in the presence of IFN-gamma activates Cat B as well as a caspase death pathway in both HUVEC and human dermal microvascular endothelial cells, but only activates caspase-mediated death in HeLa cells and human embryonic kidney (HEK)293 cells. Like LY294002, IFN-gamma triggers Cat B release from lysosomes in HUVEC. Cat B-triggered death involves mitochondria, indicated by release of cytochrome c, loss of mitochondrial membrane potential and inhibition of death by overexpressed Bcl-2. Cat B effects on mitochondria do not depend upon Bid cleavage. Unexpectedly, overexpression of a dominant negative mutated form of Fas-associated death domain protein (FADD), which blocks caspase activation by TNF, potentiates TNF activation of Cat B and cell death in HUVEC. Similarly, mutant Jurkat cells lacking FADD also show increased susceptibility to TNF-induced Cat B-dependent cell death. These observations suggest that the Cat B death pathway is cell type-specific and may contribute to cytokine-mediated human tissue injury and to the embryonic lethality of FADD gene disruption in mice.
NCP-VAE: Variational Autoencoders with Noise Contrastive Priors (2021)

Variational autoencoders (VAEs) are one of the powerful likelihood-based generative models with applications in various domains. However, they struggle to generate high-quality images, especially when samples are obtained from the prior without any tempering. One explanation for VAEs’ poor generative quality is the prior hole problem: the prior distribution fails to match the aggregate approximate posterior. Due to this mismatch, there exist areas in the latent space with high density under the prior that do not correspond to any encoded image. Samples from those areas are decoded to corrupted images. To tackle this issue, we propose an energy-based prior defined by the product of a base prior distribution and a reweighting factor, designed to bring the base closer to the aggregate posterior. We train the reweighting factor by noise contrastive estimation, and we generalize it to hierarchical VAEs with many latent variable groups. Our experiments confirm that the proposed noise contrastive priors improve the generative performance of state-of-the-art VAEs by a large margin on the MNIST, CIFAR-10, CelebA 64, and CelebA HQ 256 datasets.
Structured Deep Neural Network Pruning via Matrix Pivoting (2017)

Deep Neural Networks (DNNs) are the key to the state-of-the-art machine vision, sensor fusion and audio/video signal processing. Unfortunately, their computation complexity and tight resource constraints on the Edge make them hard to leverage on mobile, embedded and IoT devices. Due to great diversity of Edge devices, DNN designers have to take into account the hardware platform and application requirements during network training. In this work we introduce pruning via matrix pivoting as a way to improve network pruning by compromising between the design flexibility of architecture-oblivious and performance efficiency of architecture-aware pruning, the two dominant techniques for obtaining resource-efficient DNNs. We also describe local and global network optimization techniques for efficient implementation of the resulting pruned networks. In combination, the proposed pruning and implementation result in close to linear speed up with the reduction of network coefficients during pruning.
Direct coupling of micellar electrokinetic chromatography to mass spectrometry using a volatile buffer system based on perfluorooctanoic acid and ammonia (2003)

Direct coupling of micellar electrokinetic chromatography (MEKC) to mass spectrometry (MS) without employing partial filling is considered to be a challenge. One way of solving the problem would be the use of an MS-compatible surfactant. In the present study, the applicability of a series of surfactants (sodium dodecyl sulfate (SDS), lauric acid, cholic acid and perfluorated carboxylic acids) have been investigated both in terms of separation performance and MS compatibility. It was found that a MEKC system based on perfluorooctanoic acid (PFOA) and ammonia gave excellent results. The separation performance of the suggested system is comparable to the one obtained with standard systems based on SDS and sodium borate buffer although the selectivity is different. The electrospray ionization MS signal of the analytes is not seriously suppressed even at a PFOA concentration of 100 mM. Clusters are formed but their intensities are relatively low and comparable to those obtained with acetic acid. PFOA is volatile enough to allow long-term use, 30 h of continuous use has been recorded without any signs of decreasing performance. After use residual PFOA is easily removed from the ion-source (no memory effects). Furthermore, quantitation of trace impurities is possible at 25 ppb level when employing selected ion monitoring.
A new Br+ reagent. Oxidation of alcohols to carbonyl compounds by bis(quinuclidine)bromine(I) tetrafluoroborate (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new Br+ reagent. Oxidation of alcohols to carbonyl compounds by bis(quinuclidine)bromine(I) tetrafluoroborateLarry K. Blair, Kevin D. Parris, On Fai Daniel Lee, Karen F. Jenkins, Robin Chaney Feese, Tony Belcher, Diane Badger, Deborah Morris, and Christine KuhnCite this: J. Org. Chem. 1986, 51, 26, 5454–5456Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/jo00376a086https://doi.org/10.1021/jo00376a086research-articleACS PublicationsRequest reuse permissionsArticle Views183Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Highly Enhanced Affinity of Multidentate versus Bidentate Zwitterionic Ligands for Long-Term Quantum Dot Bioimaging (2012)

High colloidal stability in aqueous conditions is a prerequisite for fluorescent nanocrystals, otherwise known as "quantum dots", intended to be used in any long-term bioimaging experiment. This essential property implies a strong affinity between the nanoparticles themselves and the ligands they are coated with. To further improve the properties of the bidentate monozwitterionic ligand previously developed in our team, we synthesized a multidentate polyzwitterionic ligand, issued from the copolymerization of a bidentate monomer and a monozwitterionic one. The nanocrystals passivated by this polymeric ligand showed an exceptional colloidal stability, regardless of the medium conditions (pH, salinity, dilution, and biological environment), and we demonstrated the affinity of the polymer exceeded by 3 orders of magnitude that of the bidentate ligand (desorption rates assessed by a competition experiment). The synthesis of the multidentate polyzwitterionic ligand proved also to be easily tunable and allowed facile functionalization of the corresponding quantum dots, which led to successful specific biomolecules targeting.
Development of a Fluorescence Internal Quenching Correction Factor to Correct Botulinum Neurotoxin Type A Endopeptidase Kinetics Using SNAPtide (2012)

Botulinum neurotoxins (BoNTs), which are highly toxic proteins responsible for botulism, are produced by different strains of Clostridium botulinum. These various strains of bacteria produce seven distinct serotypes, labeled A-G. Once inside cells, the zinc-dependent proteolytic light chain (LC) degrades specific proteins involved in acetylcholine release at neuromuscular junctions causing flaccid paralysis, specifically synaptosomal-associated protein 25 (SNAP-25) for botulinum neurotoxin type A (BoNT/A). BoNT endopeptidase assays using short substrate homologues have been widely used and developed because of their ease of synthesis, detection limits, and cost. SNAPtide, a 13-amino acid fluorescence resonance energy transfer (FRET) peptide, was used in this study as a SNAP-25 homologue for the endopeptidase kinetics study of BoNT/A LC. SNAPtide uses a fluorescein isothiocyanate/4-((4-(dimethylamino)phenyl)azo) benzoic acid (FITC/DABCYL) FRET pair to produce a signal upon substrate cleavage. Signal quenching can become an issue after cleavage since quencher molecules can quench cleaved fluorophore molecules in close proximity, reducing the apparent signal. This reduction in apparent signal provides an inherent error as SNAPtide concentrations are increased. In this study, fluorescence internal quenching (FIQ) correction factors were derived using an unquenched SNAPtide peptide to quantify the signal quenching over a range of SNAPtide concentrations and temperatures. The BoNT/A LC endopeptidase kinetics at the optimally active temperature (37 °C) using SNAPtide were studied and used to demonstrate the FIQ correction factors in this study. The FIQ correction factors developed provide a convenient method to allow for improved accuracy in determining and comparing BoNT/A LC activity and kinetics using SNAPtide over a broad range of concentrations and temperatures.
Reevaluation of the significance of oxygen-18 incorporation in metal complex-catalyzed oxygenation reactions carried out in the presence of oxygen-18-labeled water (H218O) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReevaluation of the significance of oxygen-18 incorporation in metal complex-catalyzed oxygenation reactions carried out in the presence of oxygen-18-labeled water (H218O)Wonwoo Nam and Joan Selverstone ValentineCite this: J. Am. Chem. Soc. 1993, 115, 5, 1772–1778Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/ja00058a023https://doi.org/10.1021/ja00058a023research-articleACS PublicationsRequest reuse permissionsArticle Views890Altmetric-Citations136LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Flowering and Endogenous Levels of Benzoic Acid in Lemna Species (1983)

The occurrence of benzoic acid, a flower-inducing factor in Lemna species, in L. paucicostata strains 151, 381, 321 and L. gibba G3 was established by several purification steps and final use of gas liquid chromatography-selected ion monitoring. Quantitative analyses of benzoic acid were made in non-flowering and flowering Lemna to determine differences in levels. The endogenous level of benzoic acid was shown to vary depending on culture conditions, but no positive correlation could be found between the endogenous level of benzoic acid and flowering of Lemna.
Efficient cavity dumped dye laser (1978)

A theoretical and experimental investigation of cavity dumped flashlamp pumped dye lasers is described. Theory predicts that pulse time compressions of the order of 10-20 can be obtained without loss in energy efficiency. Experimental confirmation was obtained with a coaxial flashlamp dye laser. Over 300 mJ of output was obtained in a 20-nsec pulse at 490 nm.
Deformation and fracture of soda-lime-silica glass under tension by molecular dynamics simulation (2008)

The deformation and fracture of a soda-lime-silica glass were investigated under tension by molecular dynamics simulation. The process of the deformation consisted of elastic deformation, flow, and expansion accompanied with flow in the order before the glass fractured. The main structural change on each deformation was the expansion of Si-O-(Al, Si) angle, change of network rings, and growth of cavity. The cavities were generated in the region where non-bridging oxygen ions clustered and grew up in the region where Ca ions clustered in addition to the clustered non-bridging oxygen ions. The fracture time became shorter and the fracture strain and volume decreased with increasing tension.
A modified half U-slot microstrip patch antennas with shorting wall (2007)

The major limitations of microstrip antennas (MSAs) are their narrow impedance bandwidth, small gain and low power handling capability. A half U-slot MSA with shorting wall has been designed and experimentally verified. Its center frequency is observed at 2.66 GHz. The bandwidth is 688 MHz and percentage bandwidth is 25.6% has been obtained while radiation efficiency is above 94% for the operating band. A novel design for increasing the bandwidth of a rectangular patch antenna is introduced and implemented. The design concept involves cutting an extra slot on a half U-slot MSA with shorting wall loading. This new design is very useful since it improves the bandwidth of a traditional U-slot patch antenna with an advantage of reduction in size. Measured VSWR bandwidth of 20 % and average gain of 7 dBi have been achieved. The efficiency is above 95% in the entire operating range.
Cyclic Fatigue-Crack Propagation in Ceramics: Behavior in Overaged and Partially-Stabilized MgO-Zirconia (1988)

The growth of fatigue cracks under (tension-tension) cyclic loading is unequivocally demonstrated for ceramic materials, based on experiments using compact-tension specimens of a MgO partially-stabilized zirconia (PSZ), heat treated to vary the fracture toughness K{sub c} from {approximately}3 MPa{radical}m (overaged condition) to 16 MPa{radical}m (peak-toughness condition) and tested in inert and moist environments. Analogous to behavior in metals, cyclic fatigue-crack growth rates (over the range 10{sup {minus}11} to 10{sup {minus}5} m/cycle) are found to be a function of the stress-intensity range, environment, fracture toughness and load ratio, and to show evidence of crack closure. Similarly under variable-amplitude cyclic loading conditions, crack-growth rates show transient accelerations following low-high block overloads and transient retardations following high-low block overloads or single tensile overloads, again analogous to behavior commonly observed in ductile meals. Cyclic crack-growth rates are observed at stress intensities as low as 50% of K{sub c}, and are typically some 7 orders of magnitude faster than corresponding stress-corrosion crack-growth rates under sustained-loading conditions. 23 refs., 6 figs.
A type and effect system for atomicity (2003)

Ensuring the correctness of multithreaded programs is difficult, due to the potential for unexpected and nondeterministic interactions between threads. Previous work addressed this problem by devising tools for detecting race conditions , a situation where two threads simultaneously access the same data variable, and at least one of the accesses is a write. However, verifying the absence of such simultaneous-access race conditions is neither necessary nor sufficient to ensure the absence of errors due to unexpected thread interactions.We propose that a stronger non-interference property is required, namely atomicity . Atomic methods can be assumed to execute serially, without interleaved steps of other threads. Thus, atomic methods are amenable to sequential reasoning techniques, which significantly simplifies both formal and informal reasoning about program correctness.This paper presents a type system for specifying and verifying the atomicity of methods in multithreaded Java programs. The atomic type system is a synthesis of Lipton's theory of reduction and type systems for race detection.We have implemented this atomic type system for Java and used it to check a variety of standard Java library classes. The type checker uncovered subtle atomicity violations in classes such as &lt;tt&gt;java.lang.String&lt;/tt&gt; and &lt;tt&gt;java.lang.String-Buffer&lt;/tt&gt; that cause crashes under certain thread interleavings.This paper proposes that a stronger non-interference property is required, namely atomicity , and presents a type system for verifying the atomicity of methods in multithreaded Java programs. Methods in a class can be annotated with the keyword &lt;tt&gt;atomic&lt;/tt&gt;. Clients of a well-typed class can then assume that each atomic method is executed in one step, thus significantly simplifying both formal and informal reasoning about the client's correctness.
Raw Materials Based on Fly Ash of Eggs Shell and Algerian Sand Dune (Southern of Algeria) for Synthesis of Environmentally Cementitious Materials: Synthesis and Characterization (2020)

In recent years, the dominant cementitious materials have been industrial by products such as fly ash. This present paper describes some of the cementitious products that are attracting attention in the global research community and the properties and characteristics of these materials that affect their performance such durability, mechanically properties and reduction of carbon dioxid (CO2). The present investigation deals with the chemical synthesis of cementitious material using fly ash of eggs shell rich in calcium(Ca) and sand dune(southern of Algeria) rich in silica(SiO2).The composition is the most compressive resistant with a maximum stress of 49.71 MPa, the most flexible (E = 2.63 GPa) and the most ductile (&amp;epsilon;r = 65.42 %).The characteristic properties of the chemically synthesized cementitious materials were analyzed by the chemical composition analysis XRF, XRD and SEM analyses.
CELL SURFACE IMMUNOGLOBULIN (1972)

Turnover and release of cell surface Ig and secretion of total intracellular Ig has been studied in small lymphocytes from normal mouse spleen. The major findings to emerge are: (a) small lymphocytes secrete 8S IgM and IgG. A small portion of the 8S IgM, but virtually none of the IgG appears to have a cell surface phase. (b) Cell surface IgM is actively turned over with a half-life of 6-8 hr, and turnover can be accounted for by release into the incubation medium. Release is temperature dependent. (c) Released cell surface Ig is noncovalently bound to a fragment of plasma membrane. (d) H-2 antigens are not released during short-term incubation. Based on the above findings, we propose a model for the transport and release of both cell surface and conventionally secreted Ig.
Multiple wavelength generation with Brillouin/erbium fiber lasers (1996)

Brillouin/erbium fiber lasers, which have recently been demonstrated, operate with a combination of Brillouin gain and gain in erbium-doped fiber. In this letter, we describe techniques for cascading the Brillouin/erbium fiber laser to generate optical combs, and experimentally demonstrate optical comb generation. Internal and external cascading techniques are demonstrated. The line spacing in the combs is approximately 10 GHz, with operation in the 1550-nm region.
Symmetric probabilistic alignment (2005)

We recently decided to develop a new alignment algorithm for the purpose of improving our Example-Based Machine Translation (EBMT) system's performance, since subsentential alignment is critical in locating the correct translation for a matched fragment of the input. Unlike most algorithms in the literature, this new Symmetric Probabilistic Alignment (SPA) algorithm treats the source and target languages in a symmetric fashion.
Studies on Palladium(II) Complexes Containing Multidentate N-heterocycles (2005)

Palladium dihalides/perchlorate react with the multidentate N-heterocycles (I), 1,3-bis(benzimidazol-2-yl)benzene (L 1 ) 1,3-bis(1-methylbenzimidazol-2-yl)benzene (L 2 ), 2,6-bis(benzimidazol-2-yl)pyridine (L 3 ) and 2,6-bis(1-methylbenzimidazol-2-yl) pyridine (L 4 ) in ethanol/tetrahydrofuran in presence of hydrohalic acid to yield complexes of the compositions, [PdX 2 L·nH 2 O] (X = Cl, L = L 1 or L 2 , n = 1; X = Cl, L = L 3 or L 4 , n = 0; X = Br, L = L 1 or L 3 n = 0; X = Br, L = L 2 , n = 3; X = Br, L = L 4 , n = 2), PdL 2 (ClO 4 ) 2 ·nH 2 O (L = L 1 , n = 2; L = L 2 , n = 1) and [Pd 2 L 3 (ClO 4 ) 4 ·nH 2 O] (L = L 3 , n = 2; L = L 4 , n = 0). The complexes were characterised by elemental analysis, molar conductance measurements, IR, electronic, 1 H, 13 C NMR and FAB-mass spectral studies.