gebhart/patrepeval huggingface dataset:
Hydrogenation of low molar mass OH‐telechelic polybutadienes catalyzed by homogeneous Ziegler nickel catalysts (2002)

Abstract Two types of low molar mass, medium vinylic polybutadienes containing 2‐hydroxypropyl and 2‐hydroxyethyl end groups were hydrogenated in the presence of several homogeneous Ziegler Ni catalysts prepared by using Ni(acac) 2 and Ni(2‐ethylhexanoate) 2 as metal precursors and BuLi, Li adduct to a diene and Et 3 Al as activators. The catalytic efficiency of these systems determined by rate measurements showed that the best results can be achieved with the Ni(2‐hexanoate) 2 + Li‐diene (Ni : Li mol ratio = l : 8–10) catalyst in the solvents commonly used in the synthesis of these polyalkadienes by anionic polymerization of 1,3‐butadiene. As found by the kinetic study, the hydrogenation carried out under mild reaction conditions (temperatures of 10–35°C, hydrogen pressure of 72–178 kPa, Ni concentration of 2.1–10.0 mmol/dm −3 ) was the first order in the OH‐polybutadiene and hydrogen and, over narrow range of catalyst concentrations (4.3–10.0 mmol Ni/dm −3 ), also in the catalyst. The activation energy of the hydrogenation estimated from the Arrhenius plot was 42 kJ/mol. Changes in the relative proportion of 1,2‐, cis ‐1,4‐, and trans ‐1,4‐CC units of the polymer during hydrogenation indicate the selectivity of the catalyst to the 1,2‐hydrogenation. The ease of the addition of hydrogen to the internal CC unsaturation was found to be opposite to that usually observed ( trans &gt; cis ). The present low‐pressure hydrogenation of both types of telechelic OH‐polybutadienes proceeds with full retention of the average OH functionality and affords the saturated polymers, the residual CC unsaturation of which (&lt;1%) has so far been usually achieved by high‐pressure hydrogenations. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 85: 1185–1193, 2002
Demonstration of type I and type II somatomedin receptors on bovine growth plate chondrocytes (1988)

The chondrocytes of the epiphyseal growth plate are the presumed target cells for hormones regulating skeletal growth. The somatomedins, a family of low molecular weight peptides, are thought to play a stimulatory role in this regulation. The cellular actions of the somatomedins are themselves determined by binding to specific receptors on target cells. Previous studies have characterized a specific receptor for somatomedin-C (Sm-C) or insulin-like growth factor I (IGF-I) on bovine growth plate chondrocytes (GPCs). We now report the characterization of a second type of somatomedin receptor on these cells that is more specific for another class of somatomedin represented by multiplication-stimulating activity (MSA) or rat insulin-like growth factor II (rIGF-II). Binding of [125I]MSA/rIGF-II to isolated GPCs was time dependent and saturable. Unlabeled Mr 7,100 MSA/rIGF-II and Sm-C/IGF-I were approximately equipotent in competing with [125I]MSA/rIGF-II for binding, while Mr 8,600 MSA/rIGF-II was an order of magnitude less potent. Low levels of competition by insulin appeared in some studies at concentrations of 10(-7) M and higher, suggesting displacement of [125I]MSA/rIGF-II binding to the Sm-C/IGF-I receptor. In affinity-labeling studies, [125I]MSA/rIGF-I labeled a complex of Mr greater than 300,000 (unreduced) and of Mr 140,000 (reduced), consistent with a type I somatomedin receptor composed of disulfide-linked subunits. [125I]MSA/rIGF-II labeled a Mr 240,000 moiety (unreduced) and Mr 260,000 (reduced), consistent with a type II somatomedin receptor. Both affinity-labeling and kinetic data revealed cross-binding of MSA/rIGF-II and insulin with the type I receptor and of Sm-C/IGF-I with the type II receptor. In contrast, the type II receptor did not recognize insulin. These data suggest a complex pattern of graded specificity of these receptors for their ligands. These data are consistent with the hypothesis that IGF-II as well as Sm-C/IGF-I participate in the stimulation of skeletal growth.
Renal vasodilators. The role of the 4-substituent in isoquinolin-3-ol cardiovascular agents. 4-Ureido derivatives of isoquinolin-3-ol with selective renal vasodilator properties (1989)

The synthesis and cardiovascular evaluation of a series of isoquinolin-3-ol derivatives bearing a variety of nitrogen substituents (amino, acylamino, carbamate, and ureido) at C-4 are described. Certain of these compounds have a selective renal vasodilating profile and have minimal effects on arterial blood pressure or heart rate when administered intravenously in the instrumented anesthetized dog. The most potent renal vasodilator in the series is 4-(allylureido)-6,7-dimethoxyisoquinolin-3-ol (38), which at a dose of 1.2 mg/kg iv produces a 97% maximal increase in renal blood flow without significant hypotensive or chronotropic effects. Structure-activity observations on the nature of the 4-substituent and the alkoxy substitution pattern in the aromatic ring of the isoquinolinol nucleus are discussed.
Therapie von Krankheiten der Nebennierenrinde* (2008)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Platelet interaction with modified articular cartilage. Its possible relevance to joint repair. (1977)

During studies concerned with the platelet-collagen interaction, it was observed that platelets did not adhere to bovine or human articular cartilage and that cartilage did not induce platelet aggregation in vivo or in vitro. To study the mechanism responsible for this observation, the role of proteoglycans was examined. Purified cartilage collagen proved to be fully active as a platelet aggregant. Addition of small amounts of proteoglycan subunit (PGS) blocked platelet aggregation, whereas chondroitin sulfate, a major glycosaminoglycan component of cartilage matrix, impaired platelet aggregation only at concentrations which resulted in a marked increase in viscosity. Moreover, PGS abolished aggregation of platelets by polylysine but did not prevent aggregation by ADP, suggesting that PGS may block strategically placed lysine sites on the collagen molecule. Treatment of fresh articular cartilage with proteolytic enzymes rendered the tissue active as a platelet aggregant. In vivo experiments demonstrated that surgical scarification of rabbit articular cartilage does not result in adhesion of autologous platelets. Treatment of rabbit knee joints with intraarticular trypsin 1 wk before the injection of blood resulted in adhesion and aggregation of platelets on the surface of the lesions. Since there is evidence from other studies that some degree of cartilage healing may take place after initiation of an inflammatory response, it is postulated that induction of platelet-cartilage interaction may eventuate in cartilage repair.
Ovarian angiogenesis. Phenotypic characterization of endothelial cells in a physiological model of blood vessel growth and regression. (1995)

Angiogenesis occurs during embryogenesis and is a down-regulated process in the healthy adult that is almost exclusively linked to pathological conditions such as tumor growth, wound healing, and inflammation. Physiological angiogenic processes in the adult are restricted to the female reproductive system where they occur cyclically during the ovarian and uterine cycle as well as during pregnancy. By systematically analyzing the phenotypic changes of endothelial cells during bovine corpus luteum (CL) formation and regression, we have established a physiological model of blood vessel growth and regression. Quantitation of vessel density, percentage of vessels with lumen, and ratio of Bandeiraea simplicifolia-I to von Willebrand Factor-positive endothelial cells were established as parameters of angiogenesis. Sprouting endothelial cells invade the growing CL and continue to grow throughout the first third of the ovarian cycle. Thereafter the mature CL is characterized by a dense network of vessels with gradually decreasing vessel density. During luteolysis and for several weeks thereafter (regressing and residual CL) all newly formed vessels regress, which is accompanied by gradual foreshortening and rounding of endothelial cells and subsequent detachment. Based on histochemical detection of nucleosomal fragmentation products physiological blood vessel regression in the cyclic CL does not appear to involve endothelial cell apoptosis. Lectin histochemical analysis revealed a distinct alteration of endothelial cell glycoconjugate expression during ovarian angiogenesis comparable with the distinct pattern of hyperglycosylation of cultured migrating endothelial cells (up-regulation of binding sites for Lycopersicon esculentum lectin, wheat germ agglutinin, neuraminidase-treated peanut agglutinin, and Ricinus communis agglutinin-I on sprouting ECs). Northern blot analysis of glycosyltransferases during the different stages of angiogenesis revealed an up-regulation of beta-galactoside alpha 2,6-sialyltransferase and alpha 1,3-galactosyltransferase mRNA expression during the angiogenic stages of CL formation. These data establish the ovarian angiogenesis model as a suitable experimental system to study the functional and phenotypic properties of endothelial cells in sprouting and regressing blood vessels and provide additional evidence for the importance of endothelial cell surface glycoconjugates during angiogenesis.
Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents (2021)

Polymorphisms in genes related to the metabolism of vitamin B12 haven't been examined in a Brazilian population. To (a) determine the correlation between the local genetic ancestry components and vitamin B12 levels using ninety B12-related genes; (b) determine associations between these genes and their SNPs with vitamin B12 levels; (c) determine a polygenic risk score (PRS) using significant variants. This cross-sectional study included 168 children and adolescents, aged 9-13 years old. Total cobalamin was measured in plasma. Genotyping arrays and whole exome data were combined to yield ~ 7000 SNPs in 90 genes related to vitamin B12. The Efficient Local Ancestry Inference was used to estimate local ancestry for African (AFR), Native American, and European (EUR). The association between the genotypes and vitamin B12 levels were determined with generalized estimating equation. Vitamin B12 levels were driven by positive (EUR) and negative (AFR, AMR) correlations with genetic ancestry. A set of 36 variants were used to create a PRS that explained 42% of vitamin level variation. Vitamin B12 levels are influenced by genetic ancestry and a PRS explained almost 50% of the variation in plasma cobalamin in Brazilian children and adolescents.
AFPP - 22e Conférence du COLUMA - Journées Internationales sur la lutte contre les mauvaises herbes (2013)

SPE GEAPSI ECOLDUR
[A Detection Technique for Gas Concentration Based on the Spectral Line Shape Function]. (2015)

The methods that can rapidly and precisely measure concentrations of various gases have extensive applications in the fields such as air quality analysis, environmental pollution detection, and so on. The gas detection method based on the tunable laser absorption spectroscopy is considered a promising technique. For the infrared spectrum detection techniques, the line shape function of an absorption spectrum of a gas is an important parameter in qualitative and quantitative analysis of a gas. Specifically, how to obtain the line shape function of an absorption spectrum of a gas quickly and accurately is a key problem in the gas detection fields. In this paper we analyzed several existing line shape functions and proposed a method to calculate precisely the line shape function of a gas, and investigated the relation between the gas concentration and the peak value of a line shape function. Then we experimentally measured the absorption spectra of an acetylene gas in the wavelength range of 1,515-1,545 nm with a tunable laser source and a built-in spectrometer. With Lambert-Beer law we calculated the peak values of the line shape function of the gas at the given frequencies, and obtained a fitting curve for the line shape function in the whole waveband by using a computer program. Comparing the measured results with the calculated results of the Voigt function, we found that there was a deviation-between the experimental results and the calculated results. And we found that the measured concentration of the acetylene gas by using the fitting curve of the line shape function was more accurate and compatible with the actual situation. Hence, the empirical formula for the line shape function obtained from the experimental results would be more suitable for the concentration measurement of a gas. As the fitting curve for the line shape function of the acetylene gas has been deduced from the experiment, the corresponding peak values of the spectral lines can be immediately calculated out from the curve and used for the measurements of different concentrations of acetylene gases. Therefore, the calculation for the line shape function values is greatly simplified. The obtained data of the line shape function of the acetylene gas can be used for remote sensing of the gas, and the proposed method can also be applied for the measurements of line shape functions of other gases.
Prognosis and Long-term Survival of Patients with non-resected Non-small Cell Lung Cancer. (1992)

国立病院九州がんセンターに入院した非小細胞肺癌非切除例807例の予後について検討を加えた.病期が進行するにつれ予後も悪くなっていたが, I, II期では低肺機能などがありながらMSTが23.5カ月, 18.5カ月と長かった.2年以上の長期生存例は全体で11%, III, IV期に限ると9%認められた.また, 年齢, 性で差は認められなかったが, 組織型別でみると大細胞癌・他に有意に長期生存例が少なかった.年代別にみると最近の5年間 (1982-86年) は予後が良い傾向があり, 化学療法, 放射線療法などの集学的治療の進歩が寄与している可能性も考えられた.
Adapting psychologically grounded facial emotional expressions to different anthropomorphic embodiment platforms (2007)

Starting from the assumptions that human-ambient intelligence interaction will be improved by having more human-human like communications and that facial expressions are fundamental in human-human communications, we describe how we developed facial expressions for artificial agents based on a psychological theory developed by Scherer. In this current article we describe briefly the psychological theory that we have chosen as well as some of the reason for adopting it. We then describe the two different platforms we used, the Cherry avatar and the iCat Robot with a particular focus on the robot. Finally we explore the steps needed to adapt the psychological theory to the two different platforms and we present some conclusions and future development.
Two-Photon Luminescence Study of Optically Trapped InP Semiconductor Nanowires (2011)

We report the two-photon luminescence emission (2PE) study of single indium phosphide (InP) semiconductor nanowire trapped in a gradient force optical tweezers. Nanowires studied were zinc blende, wurtzite or mixed phase crystal poly-types and ranged in length from 1 to 10 μm. Our results show that the band-edge emission from two-photon absorption of nanowires trapped in solution is strong and enhanced, compared with 2PE in InP bulk material. Besides, a distinct blue shift was observed between single-photon luminescence emission (1PE) spectra and 2PE spectra.
Evaluation of Serology, 13C-Urea Breath Test, and Polymerase Chain Reaction of Stool Samples to Detect Helicobacter pylori in Bangladeshi Children (1999)

The prevalence of H. pylori infection in this periurban community and age group was high. Only serologic methods seem to be unsatisfactory for screening of H. pylori infection in infants and may not reflect the true prevalence. Immunomagnetic separation-PCR is a simple and rapid method for detection of H. pylori in stool and is an attractive method for analysis of colonization in infants. However, it may reflect a different stage of disease than UBT. Further studies are needed to clarify this.
Assessment of H-Coal process developments: impact on the performance and economics of a proposed commercial plant (1984)

This report assesses the performance of the H-Coal process, a catalytic direct liquefaction process, at a process development and large pilot-plant scale of operation. The assessment focused on the evaluation of operating results from selected long-term successful process development unit (PDU) and pilot plant runs made on Illinois No. 6 coal. The pilot plant has largely duplicated the product yield structure obtained during the PDU runs. Also, the quality of products, particularly liquid products, produced during the pilot plant run is quite comparable to that produced during the PDU runs. This confirms the scalability of the H-Coal ebullated-bed reactor system from a PDU-scale, 3 tons of coal per day, to a large pilot scale, 220 tons of coal per day, plant. The minor product yield differences, such as higher yields of C/sub 3/, C/sub 4/, and naphtha fractions, and lower yields of distillate oils obtained during pilot plant runs as compared to the PDU runs, will not impact the projected technical and economic performance of a first-of-a-kind commercial H-Coal plant. Thus, the process yield and operating data collected during the PDU operations provided an adequate basis for projecting the technical and economic performance of the proposed H-Coal commercial plant. 18 references, 9 figures, 56 tables.
Factors in Length of Foster Care: Worker Activities and Parent-Child Visitation (1996)

This is an exploratory case study investigating factors potentially related to length of foster care placements in a small western state. Findings of earlier researchers are supported. More frequent visits by natural parents are associated with shorter foster care placements.
Resuscitative Endovascular Balloon Occlusion of the Aorta as a Bridge to Organ Donation after Blunt Trauma (2022)

Solid organ transplantation is limited worldwide by a shortage of donor organs. Trauma patients with unsurvivable injuries comprise a large portion of potential organ donors, but many of them die from cardiovascular collapse before donation can be pursued. We report the use of resuscitative endovascular balloon occlusion of the aorta (REBOA) to stabilize a deteriorating patient with blunt trauma who was ultimately able to donate multiple organs and tissues. Survival to organ donation is a tangible and beneficial outcome of REBOA.
Activity of Eight Fluoroquinolones against Both Methicillin‐Susceptible and ‐Resistant Staphylococcus aureus Isolated from Skin Infections (1995)

The in vitro susceptibility of Staphylococcus aureus to eight fluoroquinolones, norfloxacin, ofloxacin, enoxacin, ciprofloxacin, lomefloxacin, tosufloxacin, sparfloxacin, and nadifloxacin was established by agar dilution tests, 71 isolates of methicillin-susceptible (MSSA) and 74 isolates of -resistant S. aureus (MRSA) isolated from skin infections. Among all of the fluoroquinolones, nadifloxacin exhibited the lowest MIC for both MSSA and MRSA. In addition, there were no resistant S. aureus, neither MSSA and MRSA, to nadifloxacin. With the exception of nadifloxacin, the incidence of MRSA resistant to fluoroquinolones has gradually increased in recent years. Over half of the MRSA strains were resistant to norfloxacin, ofloxacin, enoxacin, ciprofloxacin, and lomefloxacin.
Modulation of Stretch-Induced Enhancement of Neuronal NMDA Receptor Current by mGluR1 Depends upon Presence of Glia (2003)

Stretching of cultured neurons has been used to model diffuse axonal injury associated with brain trauma. N-Methyl-D-aspartate receptor (NMDAR) activation and group I metabotropic glutamate receptors (mGluRs) are implicated in the pathophysiology of such injury. Here we detail the effects of culture condition and mGluR1 modulation on stretch-enhanced NMDA receptor activity, and show the presence of mGluR1 in addition to mGluR5 in glia. In cortical neurons grown in the absence (PN) or presence (NG) of a glial monolayer, stretch injury (5.7 mm) enhances NMDAR activity by increasing maximal NMDAR current, decreasing the voltage-dependent Mg(2+) block, and altering the kinetic behavior of these receptors. In PN cultures, activation of mGluR1 increases stretch-enhanced NMDAR activity, whereas in NG cultures, such activity is reduced. In contrast, inhibition of mGluR1 in PN cultures limits stretch-enhanced NMDAR activity, whereas in NG cultures activity is increased. MGluR1 modulate stretch-enhanced NMDAR activity through multiple mechanisms including: altering peak or steady state current, affecting Mg(2+) blockade of the NMDAR, or by changing NMDAR kinetics. The presence of glia significantly alters the nature of mGluR1-mediated modulation of NMDAR activity and stretch-induced injury. Together these data indicate a significant neuronal/glial interaction between glial mGluR1 and neuronal NMDA receptor activity.
A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras (2008)

The c-Met receptor tyrosine kinase has been implicated in cellular transformation induced by mutant Ras, a commonly activated proto-oncogene in non-small cell lung cancer (NSCLC). However, the role of c-Met has not been defined in K-ras-mutant NSCLC, a disease for which no effective targeted therapeutic options currently exist. To acquire a greater understanding of its role, we used genetic and pharmacologic approaches to inhibit c-Met in mice and cultured cells. In Kras(LA1) mice, which develop premalignant lung lesions that progress to multifocal lung adenocarcinomas owing to somatic mutations in K-ras, c-Met was expressed in multiple cell types within premalignant lung lesions, and high concentrations of HGF were detected in bronchoalveolar lavage samples. Short-term treatment with PHA-665752, a c-Met inhibitor, decreased the numbers of premalignant lung lesions and induced apoptosis in tumor cells and vascular endothelial cells within lesions. In cell culture, PHA-665752 induced apoptosis of a lung adenocarcinoma cell line derived from Kras(LA1) mice (LKR-13) and a murine lung endothelial cell line (MEC). c-Met depletion by siRNA transfection induced apoptosis of MECs but not LKR-13 cells. Collectively, these findings suggest that apoptosis was an on-target effect of PHA-665752 in MECs but not in LKR-13 cells. We conclude that PHA-665752 inhibited lung tumorigenesis in Kras(LA1) mice and may provide a novel therapeutic approach to the prevention of K-ras-mutant NSCLC.
In Situ Study of Chemical Reaction between Silicon and Graphite at l,400°C in a High Resolution/Analytical Electron Microscope (1994)

A chemical reaction between Si and graphite around l,400°C has been observed in situ at near-atomic resolution in a high-resolution/analytical electron microscope. The variation in chemical composition has also been studied using an EDX analysis during the in situ experiment. It has been concluded that Si atoms diffuse into graphite, react with carbon, and form SiC crystals.