gebhart/patrepeval huggingface dataset:
O21 Single-cell RNA sequencing and proteomic analysis of dermal fibroblasts cultured from female scalp identifies significant alterations in cell populations with age (2023)

Abstract We have previously reported that significant in situ detrimental changes occur in the female scalp with age. We also reported that primary cultures of female scalp dermal fibroblasts (DF) significantly increase the secretion of proteins such as cartilage oligomeric matrix protein/thrombospondin-5 (COMP/TSP5), secreted protein acidic and cysteine rich (SPARC) and smooth muscle actin (ACTA2). This highlights changes in DF cellular identity with age, altering the immediate hair follicle environment, presumably driving hair ageing. To gain a better understanding of age-related molecular and functional changes in DFs, we compared both the transcriptional and proteomic profile of primary cultures of scalp DFs (passage &amp;lt; 3) from female donors (n = 8) aged 21–77 years. Transcriptional profiles were analysed via 10× Genomics scRNAseq. Data profiles were generated by evaluation of cellular lysates by liquid chromatography mass spectrometry proteomics and compared by MS1 precursor intensities using PEAKS software. A total of 16 166 DF cells from young (n = 3) and older (n = 3) donors were sequenced. Across the two populations, 11 transcriptionally distinct clusters were detected, highlighting the heterogeneity in DFs. The percentage of cells in these clusters changed with age, and gene set enrichment analysis ascertained a significant increase of cells in cluster 2, which represented a higher number of gene sets related to fibrosis, senescence, collagen synthesis and degradation. Proteomic analysis of DF cellular proteins (four donors in each age group) identified 11 significantly differentially expressed proteins between the two age groups. Two proteins (serine/threonine-protein kinase 38 and rho GTPase activating protein 21) were significantly reduced in the older cohort, while nine proteins (smoothelin, retinol dehydrogenase 5 tetranectin, oestradiol 17-beta-dehydrogenase 11, CD14, carboxypeptidase M, gamma-enolase, plexin-B1 and endoplasmic reticulum membrane protein complex subunit 4) were significantly elevated in the older cohort. Gene Ontology and STRING analysis of the data revealed modifications to key pathways with age (e.g. collagen and elastic fibre formation, autophagy, ubiquitination and metabolic markers). This study highlights the loss of scalp DF cell signature and identity with age. We hypothesize that these changes impact on the ability of the scalp dermal environment to support and maintain healthy hair follicles, contributing to the age-related changes observed in female hair growth.
Characteristics of Starch Networks within Rice Flour Noodles and Mungbean Starch Vermicelli (1988)

ABSTRACT Starchy networks within mungbean starch vermicelli and rice flour noodles are characterized by differential scanning calorimetry, X‐ray diffraction, mild acid hydrolysis, and gel permeation studies. In these products, native starch structures disappeared but new crystalline organizations were found. An amylopectin‐based crystallinity was evident from its B‐type diffraction pattern, melting endotherm at 50°C and high susceptibility towards mild acid hydrolysis. In addition, amylose‐based structures were present either in the complexed form (V‐type) in rice flour noodles, or in the retrograded form (B‐type) in both pasta‐like products. These latter crystallites were highly resistant towards mild acid hydrolysis and melted at high temperatures. Both glutenfree pasta‐like products exhibited good cooking behavior which can be attributed to these amylose networks.
Attribute-based encryption with non-monotonic access structures (2007)

We construct an Attribute-Based Encryption (ABE) scheme that allows a user's private key to be expressed in terms of any access formula over attributes. Previous ABE schemes were limited to expressing only monotonic access structures. We provide a proof of security for our scheme based on the Decisional Bilinear Diffie-Hellman (BDH) assumption. Furthermore, the performance of our new scheme compares favorably with existing, less-expressive schemes.
Room‐Temperature Self‐Healing and Recyclable Tough Polymer Composites Using Nitrogen‐Coordinated Boroxines (2018)

Abstract In this paper, nitrogen‐coordinated boroxines are exploited for the fabrication of self‐healing and recyclable polymer composites with enhanced mechanical properties. The 3D polymer networks cross‐linked with nitrogen‐coordinated boroxines are first synthesized through the trimerization of ortho ‐aminomethyl‐phenylboronic acid groups at the terminals of poly(propylene glycol) (PPG) chains, and subsequently, the mechanically robust polymer composites are fabricated by utilizing the complexation of nitrogen‐coordinated boroxine‐containing PPG (N‐boroxine‐PPG) with poly(acrylic acid) (PAA) and hydrogen‐bonding interactions between them. The N‐boroxine‐PPG is soft with a tensile strength of 0.19 MPa, whereas the tensile strengths of N‐boroxine‐PPG/PAA composites can be tailored to range from 1.7 to 12.7 MPa by increasing the PAA contents in the polymer composites. It is revealed that the amine ligands can facilitate the formation and dissociation of nitrogen‐coordinated boroxines at room temperature. Moreover, the reversibility of nitrogen‐coordinated boroxines and hydrogen‐bonding interactions enable multiple cycles of healing and recycling of the damaged N‐boroxine‐PPG/PAA composites. The healed and recycled N‐boroxine‐PPG/PAA polymer composites regain most of their mechanical strength.
Analysis of the Powertrain Component Size of Electrified Vehicles Commercially Available on the Market (2021)

The paper aims to present an analysis of the component sizes of commercially available vehicles with electrified powertrains. The paper provides insight into how the powertrain components (an internal combustion engine, an electric motor and a battery) of mass production electrified vehicles are sized. The data of wide range of mass production electrified vehicles are collected and analyzed. Firstly, the main requirements to performance of a vehicle are described. The power values to meet the main performance requirements are calculated and compared to the real vehicle data. Based on the calculated values of the power requirements the minimum sizes of the powertrain components are derived. The paper highlights how the sizing methodologies, described in the research literature, are implemented in sizing the powertrain of the commercially available electrified vehicles.
ChemInform Abstract: 10‐Alkyl‐2,7‐dinitro‐9(10H)‐acridinones by Tandem SNAr Reactions. (2011)

Abstract Title compounds (VI) are formed smoothly by tandem S N Ar reaction while all attempts to cyclize the mono‐nitro substrate (IX) fail.
A Persistent Spatial Semantic Representation for High-level Natural\n Language Instruction Execution (2021)

Natural language provides an accessible and expressive interface to specify\nlong-term tasks for robotic agents. However, non-experts are likely to specify\nsuch tasks with high-level instructions, which abstract over specific robot\nactions through several layers of abstraction. We propose that key to bridging\nthis gap between language and robot actions over long execution horizons are\npersistent representations. We propose a persistent spatial semantic\nrepresentation method, and show how it enables building an agent that performs\nhierarchical reasoning to effectively execute long-term tasks. We evaluate our\napproach on the ALFRED benchmark and achieve state-of-the-art results, despite\ncompletely avoiding the commonly used step-by-step instructions.\n
BRAFV600E Cooperates with PI3K Signaling, Independent of AKT, to Regulate Melanoma Cell Proliferation (2014)

PI3K, but not AKT, represent potential targets for melanoma therapy.
Multicolor oligothiophene-based light-emitting diodes (2001)

We demonstrate wide tunability, from green to near infrared, of the electroluminescence emission of substituted oligothiophene compounds. The compounds are characterized by high chemical stability, electron affinities up to 3.1 eV and photoluminescence efficiencies up to 70%. These characteristics make these materials excellent candidates for application in light-emitting diodes. We obtain low turn-on voltage devices with electroluminescence efficiency up to 0.2%, more than one order of magnitude larger than the values reported for unsubstituted oligothiophene compounds.
Design of Experiments (DoE): a multivariate approach to dye-sensitized solar cells comprehension and optimization (2014)

Nowadays, modern science proposes and optimizes new materials and technologies, whose characteristics and performances are governed by many factors. However, the scientific community rarely adopts multivariate strategies for the comprehension of what is proposed. As a striking example, a standard dye-sensitized solar cell (DSSC) is a typical complex system assembled with different and heterogeneous layers (FTO/nanocrystalline semiconductor/sensitizer/electrolyte/Pt-FTO), each one affected by intrinsic variability; moreover the layers influence each other and this increases the number of variables involved at the same time in the photoconversion process. The idea of the present work started from the need to identify all the factors by which the photoconversion processes may be influenced. In order to obtain a significant improvement of photovoltaic performances, particularly in reproducibility, long-term stability and efficiency, a chemometric design of experiments (DoE) approach is here presented for four case studies: the formulation of a UV-cured polymer electrolyte membrane, the composition of a cellulose-based gel-polymer electrolyte, the proper sensitization of a ZnO photoanode and the photostability optimization of a series of NIR dyes under different dipping conditions. We are firmly convinced that this approach will make possible to find the optimal experimental conditions to achieve, within a good reproducibility, optimized performances, both in term of efficiency and long term stability
[Angiogenesis and macrophage infiltration in Borrmann type IV gastric cancer]. (2001)

The clinical significance of angiogenesis was investigated in Borrmann type IV gastric cancer. Tumors with high microvessel density (MVD) often metastasized to the liver and lymph nodes. A significant correlation was recognized between macrophage infiltration and MVD. However, MVD was not a prognostic factor. Peritoneal dissemination was a prognostic factor in Borrmann type IV gastric cancer. Thus, angiogenesis plays an important role in the metastasis, but not prognosis in Borrmann type IV gastric cancer.
Estimation of radiometric parameters for a realistic rendering of 3D models (2003)

In order to obtain realistic results in the rendering of a 3D model, we need accurate information on both structure (shape) and radiometric properties (reflectivity) of its surfaces. In this paper, we approach the problem of correctly estimating the radiometric characteristics of an imaged surface through the analysis of several of its views. The images are acquired with one or more CCD cameras that move around the object, and the 3D model is assumed available (it can be constructed from the available images). The adopted reflectivity model is non-Lambertian as it takes into account both the diffuse lobe and the specular lobe. The method implements a robust technique which is able to estimate the reflectivity parameters of the object's surfaces even in the presence of modeling imperfections and/or when the relative camera-object position and orientation are only approximately known.
A 3D Vertical-Channel Ferroelectric/Anti-Ferroelectric FET With Indium Oxide (2022)

A vertical channel ferroelectric-FET (FeFET) with HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -based ferroelectric (Fe-HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) and atomic layer deposition (ALD) Indium oxide (InOx) channel has been developed and demonstrated for 3D high-density memory applications. Reliable memory operation has been confirmed with memory window (MW) >1V in gate length (L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> ) = 50nm short channel FeFETs. Polar-axis transition of Fe-HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> from in- plane in the initial film to out-of-plane after electrical cycling has been verified by both experimental and theoretical studies. A vertical channel anti-ferroelectric (AFe) FET (AFeFET) with ZrO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> has been also demonstrated by making use of half-loop hysteresis in AFe, which can be a new solution for the weak erase problem seen in oxide semiconductor channel FeFETs.
Hematologic adaptation to mask‐wearing among pregnant women and obstetrical outcome during the coronavirus disease 2019 pandemic (2021)

A hard-to-ventilate space created by wearing a mask during the COVID-19 era may be the underlying cause of the observed higher hemoglobin level among pregnant women, possibly affecting obstetrical outcomes.
High-temperature resistant, ordered gold nanoparticle arrays (2006)

Ordered gold nanoparticle arrays with high lateral density of 6.87 × 1010 nanoparticles cm−2, which are stable up to temperatures of 600 °C, were fabricated. To this end, nanoparticles formed by thermal vacuum evaporation of Au were immobilized within the pores of nanoporous silicon wafers prepared by block copolymer lithography coupled with dry plasma etching. Even after high-temperature treatment the degree of order imposed by the block copolymer template was retained. Optionally, a nanoporous silicon nitride mask can cover the nanoporous silicon.
Achievement of a high-mobility FET with a cloud-aligned composite oxide semiconductor (2016)

Abstract We have recently discovered that films of a widely used In–Ga–Zn oxide (IGZO) with have different material composition states when sputter-deposited under different conditions using the same polycrystalline IGZO target. Significant improvements in on-state current and mobility (as high as 40 cm 2 ·V −1 ·s −1 ) are obtained. The results of local composition analysis indicate that the deposited film is not composed of any known homogeneous IGZO compound and that the components of this film are separated into two types of nanoparticle regions: one type is composed mainly of GaO x and GaZnO x , which contribute to on/off (switching) characteristics, and the other is composed mainly of InO x and InZnO x , which contribute to on-state characteristics. These regions constitute a new type of oxide semiconductor (OS) film. The nanoparticles with a blurry boundary extend like a cloud, probably complementing one another. We consider that this OS film has a novel composition, which can be described as a “cloud-aligned composite OS” (CAC-OS).
Pair Density Wave in the Doped t−J Model with Ring Exchange on a Triangular Lattice (2019)

In our previous work [Phys. Rev. Lett. 121, 046401 (2018)PRLTAO0031-900710.1103/PhysRevLett.121.046401], we found a quantum spin liquid phase with a spinon Fermi surface in the two dimensional spin-1/2 Heisenberg model with four-spin ring exchange on a triangular lattice. In this work we dope the spinon Fermi surface phase by studying the t-J model with four-spin ring exchange. We perform density matrix renormalization group calculations on four-leg cylinders of a triangular lattice and find that the dominant pair correlation function is that of a pair density wave; i.e., it is oscillatory while decaying with distance with a power law. The doping dependence of the period is studied. This is the first example where a pair density wave is the dominant pairing in a generic strongly interacting system where the pair density wave cannot be explained as a composite order and no special symmetry is required.
Addition of Primary Care–Based Retinal Imaging Technology to an Existing Eye Care Professional Referral Program Increased the Rate of Surveillance and Treatment of Diabetic Retinopathy (2005)

Implementing retinal imaging technology in a primary care setting resulted in a significant increase in the rate of diabetic retinopathy surveillance and a proportional increase in the rate of laser treatment for diabetic retinopathy for a large patient population. Application of this technology in primary care settings holds the potential to extend sight-preserving care by increasing access to appropriate retinal care.
Novel pyridinium-based cationic lipids as gene delivery vectors (2012)

Background: For the past two decades, cationic lipids have remained one of the most widely used non-viral gene delivery vectors due in large to their safety and ease of use despite having low efficiency. We and others believe that the key to improving the effectiveness of non-viral agents is unlocking the still unsolved mechanism behind lipid gene delivery. Our objective is the rational design, synthesis and evaluation of the DNA complexation and in vitro delivery efficiency of novel lipid vectors in an effort to gain structure-function data which may give insight towards the non-viral mechanism. Objectives: Here we report preliminary data on two novel pyridinium-based cationic lipid vectors, designated as TFSA (saturated acyclic structure) and TFUA (unsaturated acyclic structure), both possessing a pyridinium headgroup with a delocalized positive charge, and two saturated (TFSA) or monounsaturated (TFUA) C15 hydrophobic alkyl chains. In the case of the unsaturated analogue, the double bonds are located at the terminal ends of the alkyl chains. Methods: Liposomes were prepared from these novel pyridinium-based cationic lipids in combination with a commercial vector, EPC, together with a co-lipid, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) or cholesterol. Lipid-DNA complexes (lipoplexes) were then formulated by incubating the liposomes with plasmid DNA. Lipoplexes were characterized by gel retardation, DNAse I degradation, as well as biocompatibility and β-galactosidase (β-gal) transfection assays using Chinese Hamster Ovarian (CHO-K1) cells. Fluorescent GFP-plasmid DNA was used to track DNA inside cells using epifluorescence microscopy. Results: The novel lipid formulations were shown to effectively complex DNA and protect it from DNAse I degradation. They were biocompatible with CHO-K1 cells, and performed better when they were formulated with cholesterol over DOPE as co-lipid. Furthermore, the formulation containing the unsaturated compound (TFUA/EPC/DOPE) revealed transfection efficiencies far above TFSA/EPC/DOPE, and superior to the commercial transfection agent EPC formulated alone with DOPE. Results from the GFP-plasmid tracking experiments were consistent with the relative β-gal expressions observed in the transfection assay. Conclusions: These preliminary results suggest that our novel pyridinium-based cationic lipid vectors are effective gene transfer agents, suitable for further investigations into the mechanism of non-viral gene delivery.
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. (1996)

Type I (alpha, beta) and type II (gamma) interferons (IFNs) can restrict the growth of many cell types. INF-stimulated gene transcription, a key early event in IFN response, acts through the Janus kinase-signal transducers and activators of transcription pathway, in which both IFN-alpha and IFN-gamma activate the transcription factor Stat1. A cell line lacking Stat1 (U3A) was not growth-arrested by IFN-alpha or IFN-gamma, and experiments were carried out with U3A cells permanently expressing normal or various mutant forms of Stat1 protein. Only cells in which complete Stat1 activity was available (Stat1alpha) were growth-inhibited by IFN-gamma. A mutant that supports 20-30% normal transcription did not cause growth restraint. In contrast, IFN-alpha growth restraint was imposed by cells producing Stat1beta, which lacks transcriptional activation potential. This parallels earlier results showing the truncated Stat1 can function in IFN-alpha gene activation. In addition to experiments on long-term cultured cells, we also found that wild-type primary mouse embryonic fibroblasts were inhibited by IFNs, but fibroblasts from Stat1-deficient mouse embryos were not inhibited by IFNs.
Crystal growth and characterization of Yb3+-doped LiLuF4 for radiation-balanced lasers (Conference Presentation) (2020)

We report on the Bridgman crystal growth of Yb3+-doped LiLuF4 (LLF:Yb) for radiation balanced laser (RBL) applications. Crystals were grown on both radio-frequency (RF) heated and resistively heated furnaces starting from the binary fluorides LiF, LuF3, and YbF3. Graphite crucibles were found to introduce excessive amounts of carbon contamination, while glassy carbon crucibles offered significantly better results. In a preliminary experiment, a LLF:Yb crystal grown by this method showed laser-induced cooling when excited at 1055 nm with 810 mW in a setup with the crystal in air and measuring the temperature change by a thermal camera.
Heart failure—potential new targets for therapy (2016)

Therapeutic targets directed towards modifying the extracellular environment, angiogenesis, cell viability, contractile function and microRNA-based therapies.
Pressure-Volume-Temperature Studies of Amorphous and Crystallizable Polymers. I. Experimental (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPressure-Volume-Temperature Studies of Amorphous and Crystallizable Polymers. I. ExperimentalOlagoke Olabisi and Robert SimhaCite this: Macromolecules 1975, 8, 2, 206–210Publication Date (Print):March 1, 1975Publication History Published online1 May 2002Published inissue 1 March 1975https://pubs.acs.org/doi/10.1021/ma60044a022https://doi.org/10.1021/ma60044a022research-articleACS PublicationsRequest reuse permissionsArticle Views884Altmetric-Citations235LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Optimal Aggregation of Classifiers and Boosting Maps in Functional Magnetic Resonance Imaging (2004)

We study a method of optimal data-driven aggregation of classifiers in a convex combination and establish tight upper bounds on its excess risk with respect to a convex loss function under the assumption that the so-lution of optimal aggregation problem is sparse. We use a boosting type algorithm of optimal aggregation to develop aggregate classifiers of ac-tivation patterns in fMRI based on locally trained SVM classifiers. The aggregation coefficients are then used to design a ”boosting map ” of the brain needed to identify the regions with most significant impact on clas-sification. 1