gebhart/patrepeval huggingface dataset:
Tuning the strain-induced resonance shift in silicon racetrack resonators by their orientation (2018)

In this work, we analyze the role of strain on a set of silicon racetrack resonators presenting different orientations with respect to the applied strain. The strain induces a variation of the resonance wavelength, caused by the photoelastic variation of the material refractive index as well as by the mechanical deformation of the device. In particular, the mechanical deformation alters both the resonator perimeter and the waveguide cross-section. Finite element simulations taking into account all these effects are presented, providing good agreement with experimental results. By studying the role of the resonator orientation we identify interesting features, such as the tuning of the resonance shift from negative to positive values and the possibility of realizing strain insensitive devices.
IFLA August 2002 a first-timer's perspective (2002)

I arrived in Glasgow on the Sunday afternoon with a week ahead of me discovering more about librarianship. How interesting was this likely to be?
M3R (2012)

Main Memory Map Reduce (M3R) is a new implementation of the Hadoop Map Reduce (HMR) API targeted at online analytics on high mean-time-to-failure clusters. It does not support resilience, and supports only those workloads which can fit into cluster memory. In return, it can run HMR jobs unchanged -- including jobs produced by compilers for higher-level languages such as Pig, Jaql, and SystemML and interactive front-ends like IBM BigSheets -- while providing significantly better performance than the Hadoop engine on several workloads (e.g. 45x on some input sizes for sparse matrix vector multiply). M3R also supports extensions to the HMR API which can enable Map Reduce jobs to run faster on the M3R engine, while not affecting their performance under the Hadoop engine.
Application of Indirect Flow Rate Measurement Using Motor Driving Signals to a Centrifugal Blood Pump with an Integrated Motor (2001)

The method of measuring the flow rate of a centrifugal blood pump from the input electric power, which will be indispensable for the long-term use of such devices, was developed and was applied to the direct-driven centrifugal blood pump that has been developed by our research group. The accuracy was evaluated in a chronic animal experiment using an adult goat. The results demonstrated that this method carries the sufficient potential of the instantaneous monitoring method, but errors due to electromagnetic and mechanical losses were not determined always precisely. The detection of adverse phenomena such as the obstruction of the inlet cannula was also possible from the estimated value of the flow rate and its waveform pattern.
Cover Image, Volume 87, Issue 3 (2019)

Cover: The cover image is based on the Research Article Residue-level determinants of angiopoietin-2 interactions with its receptor Tie2 by Anna Bakhman et al., DOI: 10.1002/prot.25638.
Mission reliability evaluation based on operational quality data for multistate manufacturing systems (2018)

Modern and intelligent manufacturing systems have a prominent multistate feature. However, previous studies of reliability analysis of multistate manufacturing systems mostly focused on the basic reliability of manufacturing systems but disregarded their operating characteristics, which has hindered the development of Prognostics and Health Management technique for intelligent manufacturing systems. Therefore, an evaluation approach of mission reliability for multistate manufacturing systems based on operational quality data is proposed in this paper. First, from the systematic viewpoint of the composition and operational principle of the manufacturing system, the relationship among production task execution state, production equipment degradation state, and produced product quality state is expounded, and the connotation of the mission reliability of multistate manufacturing systems is defined. Second, an extended state task network (ESTN) is presented to organise operational quality data by considering the quality state of work in process (WIP). Third, a fusion model of operational quality data for manufacturing systems is established with the aid of the ESTN, and an operational quality data-oriented evaluation method of mission reliability is been put forward. Finally, a case study of a manufacturing system for a cylinder head is conducted to verify the proposed approach.
Mechanical probing of liquid foam ageing (2005)

We present experimental results on the Stokes experiment performed in a 3D dry liquid foam. The system is used as a rheometric tool : from the force exerted on a 1cm glass bead, plunged at controlled velocity in the foam in a quasi static regime, local foam properties are probed around the sphere. With this original and simple technique, we show the possibility of measuring the foam shear modulus, the gravity drainage rate and the evolution of the bubble size during coarsening.
Preparation of hydrogenated amorphous carbon films using a microsecond-pulsed DC capacitive-coupled plasma chemical vapor deposition system operated at high frequency up to 400 kHz (2018)

Hydrogenated amorphous carbon (a-C:H) films are deposited on silicon (Si) substrates using a high-repetition microsecond-pulsed DC plasma chemical vapor deposition (CVD) system from acetylene (C2H2) at a gas pressure of 15 Pa inside a custom-made vacuum chamber. The plasma discharge characteristics, hydrocarbon species, and the microstructure of the resulting films are examined at various pulse repetition rates from 50 to 400 kHz and a fixed duty cycle of 50%. The optical emission spectra confirmed the increase in electron excitation energy from 1.09 to 1.82 eV and the decrease in the intensity ratio of CH/C2 from 1.04 to 0.75 with increasing pulse frequency, indicating the enhanced electron impact dissociation of C2H2 gas. With increasing pulse frequency, the deposition rate gradually increased, reaching a maximum rate of 60 nm/min at 200 kHz, after which a progressive decrease was noted, whereas the deposition area was almost uniform for all the prepared films. Clear trends of increasing sp3 content (amorphization) and decreasing hydrogen (H) content in the films were observed as the pulse repetition rate increased, while most of the hydrogen atoms bonded to carbon atoms by sp3 hybridization rather than by sp2 hybridization.
Fabrication of Microlens Array and Its Application: A Review (2018)

Microlens arrays are the key component in the next generation of 3D imaging system, for it exhibits some good optical properties such as extremely large field of view angles, low aberration and distortion, high temporal resolution and infinite depth of field. Although many fabrication methods or processes are proposed for manufacturing such precision component, however, those methods still need to be improved. In this review, those fabrication methods are categorized into direct and indirect method and compared in detail. Two main challenges in manufacturing microlens array are identified: how to obtain a microlens array with good uniformity in a large area and how to produce the microlens array on a curved surface? In order to effectively achieve control of the geometry of a microlens, indirect methods involving the use of 3D molds and replication technologies are suggested. Further development of ultraprecision machining technology is needed to reduce the surface fluctuation by considering the dynamics of machine tool in tool path planning. Finally, the challenges and opportunities of manufacturing microlens array in industry and academic research are discussed and several principle conclusions are drawn.
Mannoside Glycolipid Conjugates Display Antiviral Activity Against Ebola Virus (2018)

The West African outbreak of Ebola virus (EBOV) infection during 2013-2016 highlighted the need for development of field-applicable therapeutic drugs for this infection. Here we report that mannoside glycolipid conjugates (MGCs) consisting of a trimannose head and a lipophilic chain assembled by a linker inhibit EBOV infection not only of human monocyte-derived dendritic cells and macrophages, but also of a number of susceptible cells. Analysis of the mode of action leads us to conclude that MGCs act directly on cells, notably by preventing virus endocytosis.
Characterization of Spatiotemporal Coupling with a Hyperspectral Hartmann Wavefront Sensor (2018)

A broadband optical source is directly characterized using a Hartmann wavefront sensor implemented with a custom hyperspectral camera, yielding the accurate experimental characterization of radial group delay and pulse-front tilt.
Cover Image, Volume 66, Issue 10 (2017)

The cover image, by Bruna A. Bregadiolli et al., is based on the Research Article Towards the synthesis of poly(azafulleroid)s: main chain fullerene oligomers for organic photovoltaic devices , DOI: 10.1002/pi.5419 . image
Synthesis and Oxygen Permeation Properties of Sr 2.7 La 0.3 Fe 2−y M y O 7−δ (M = Mn, Co and Ni) (2006)

This chapter contains sections titled: Abstract Introduction Experimental Results and Discussion Conclusions Acknowledgement
Evolving Trends in the Dereplication of Natural Product Extracts: New Methodology for Rapid, Small-Scale Investigation of Natural Product Extracts (2008)

The use of an HPLC bioactivity profiling/microtiter plate technique in conjunction with capillary probe NMR instrumentation and access to appropriate databases effectively short-circuits conventional dereplication procedures, necessarily based on multimilligram extracts, to a single, more rapid submilligram operation. This approach to dereplication is illustrated using fungal or bacterial extracts that contain known compounds. In each case the dereplication steps were carried out on microgram quantities of extract and demonstrate the discriminating power of (1)H NMR spectroscopy as a definitive dereplication tool.
ChemInform Abstract: Tetraammonium Hexahydrogenhexamolybdozincate(II) Hexahydrate. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: CHEMICAL AND PHARMACOLOGICAL STUDIES ON PYRAN DERIVATIVES. XV. PHENYL‐SUBSTITUTED 2‐(DIALKYLAMINO)CHROMONES (1983)

Some 2-(dialkylamino)chromones phenyl substituted in position 6 or 7 or 8 were synthesized by reaction of N,N-dialkylethoxycarbonylacetamides with 4- or 3- or 2-biphenylol, respectively, in the presence of phosphorus oxychloride. The pharmacological activity of these compounds was then evaluated and compared with that shown by naphthopyran derivatives of structures (I), (II), and (III). With this same purpose also 6- and 8-benzyl derivatives of 2-(dialkylamino)chromones were prepared by using in the reaction 4- or 2-benzylphenol. Pharmacological screening showed that 6-phenyl substituted 2-(dialkylamino)chromones maintained the antireserpine and antimetrazole acti-activities which were possessed by the 1H-naphtho[2,1-b]pyran derivatives (I) and the 4H-naphtho[2,3-b]pyran derivatives (II), whereas 7-phenyl substituted compounds were devoid of any activity. 8-Phenyl substituted 2-(dialkylamino)chromones maintained to some extent the antiamphetamine activity which was clearly shown by the 4H-naphtho[1,2-]pyran derivatives (III). Furthermore, the compounds bearing the benzyl substituent both in the 6 or 8 position showed only antimetrazole activity.
Not for Novices (1985)

One really nice feature of DOS batch files is that they accept “command‐line parameters”. For example, consider a batch file called COPYTOA.BAT, which might be used to copy a file or group of files to drive A. COPYTOA.BAT would consist of the following line:
Four year Longitudinal Assessment of DAT Imaging Biomarkers in a Progressing Parkinson Disease Cohort: Analysis Strategies and Implications for Treatment Trial Design (2018)

628 Objectives: Imaging measures of presynaptic dopaminergic function have been proposed as Parkinson Disease (PD) progression biomarkers offering a more objective measure of disease status in assessment of disease modifying therapies. The Parkinson Progression Marker Initiative (PPMI) study is an international, multicenter longitudinal evaluation of biomarkers in a progressing early Parkinson9s disease cohort. The aims of this study are to evaluate within subject changes in dopamine (DAT) using 123-I Ioflupane SPECT in PD participants studied over four years employing different analysis strategies for enhancing signal:noise (S:N) of the change signal in different striatal subregions and statistical power for detecting slowing/cessation of signal loss in clinical trials.
 Methods: In an ongoing study 259 de novo PD subjects completed baseline,1yr, 2yr, and 4yr clinical and 123I-Ioflupane/SPECT evaluation. Changes in specific binding ratio (SBR) between baseline and 2-yr, 3-yr, and 4-yr scans were calculated for ipsilateral and contralateral striatum as well as striatal subregions. In addition, monoexponential curve fitting was performed in all subregions and composite striatal SBRs, absolute and percent loss and area under curve calculated and compared to standard analyses for change in SBR relative to variance (S:N) and robustness of correlation with clinical ratings of PD symptoms Results: Longitudinal follow-up of the PPMI cohort demonstrates annualized rates of % change in DAT composite SBR to be10-12% in the first year with lower reductions in SBR by year 4, for an average annualized change of 7%. The SBR change signal is roughly identical between the two methods within each time cohort. However, the exponential analysis in both 2 and 4 year groups has superior S:N over standard methods.Similarly, correlational analyses vs UPDRS motor scores are more robust in the exponential fit analysis compared to the standard Methods: Finally sample size estimates for detecting a 50% reduction in the rate of signal loss are 55-60% lower in the exponential fit method than the standard method. Conclusions: The use of 123-I ioflupane SPECT as a biomarker of PD progression is feasible from the perspective of the size of signal change in an early PD cohort studied over 2-4 years with best S:N properties in the exponential fit to the serial regional SBRs resulting in better correlation with motor scores and lower sample size for achieving similar power compared to the standard analysis method.
Living in the comfort zone (2007)

A comfort zone is a tested region of a system's input space within which it has been observed to behave acceptably. To keep systems operating within their comfort zones, we advocate the interposition of rectifiers between systems and their input sources. Rectifiers are designed to transform inputs to ensure that they are within the comfort zone before they are presented to the system. Rectifiers enforce a highly constrained input format and, if necessary, discard information to force inputs to conform to this format. Potential benefits of this approach include the elimination of errors and vulnerabilities, the excision of undesirable excess functionality from large, complex systems, and a simplification of the computing environment. We have developed a rectifier for email messages and used this rectifier to force messages into a specific constrained form. Our results show that this rectifier can successfully produce messages that keep the Pine email client strictly within code previously confirmed (during a small testing and training session) to function acceptably. Our results also show that the rectifier completely eliminates a security vulnerability in the Pine email client. And finally, the rectifier is able to accomplish these goals while still preserving an acceptable amount of information from the original messages.
A Parametric Framework for Video Compression Using Region-Based Texture Models (2011)

This paper presents a novel means of video compression based on texture warping and synthesis. Instead of encoding whole images or prediction residuals after translational motion estimation, our algorithm employs a perspective motion model to warp static textures and utilizes texture synthesis to create dynamic textures. Texture regions are segmented using features derived from the complex wavelet transform and further classified according to their spatial and temporal characteristics. Moreover, a compatible artifact-based video metric (AVM) is proposed with which to evaluate the quality of the reconstructed video. This is also employed in-loop to prevent warping and synthesis artifacts. The proposed algorithm has been integrated into an H.264 video coding framework. The results show significant bitrate savings, of up to 60% compared with H.264 at the same objective quality (based on AVM) and subjective scores.
Hele-Shaw Cell of Varying Thickness for Modeling of Leakage Pathways (2020)

&amp;lt;p&amp;gt;Canada is an important player in the global oil and gas industry and is ranked fourth largest producer of natural gas and crude oil. Alberta and British Columbia are the two largest producing provinces of natural gas with a combined 98% of the national production. Recent development of the Montney formation, a low permeability unit, has led to a rise in the number of unconventional (horizontal and hydraulically fractured) wells drilled in Western Canada. Recent studies have shown that 28.5% of wells drilled starting in 2010 in British Columbia have reported an instance of wellbore leakage, and 4.0% of the wells drilled in Alberta during the same time period have also reported an instance of wellbore leakage resulting in several thousand wells with known leakage issues in these two provinces. Wellbore leakage is the unwanted flow of hydrocarbons from the reservoir, or a formation intersected by the well, through leakage pathways found along the wellbore and discharging to the atmosphere through either the surface casing assembly, surface casing vent flow (SCVF) or a surrounding permeable formation, gas migration (GM). In addition to the greenhouse gas emissions produced by wellbore, groundwater contamination may occur. Provincial regulations state that the remediation of cases of non-serious wellbore leakage, which represents 85.5% of the cases of wellbore leakage in Alberta and over 94% of the cases in British Columbia, can be delayed until the time of well abandonment. Less than 30% of the gas wells in these provinces have been abandoned and both provinces are seeing an alarming number of suspended wells which can be considered ready for abandonment. At which point, wells experiencing wellbore leakage will need to be remediated. Understanding of wellbore leakage, which occurs through leakage pathways such as radial cracks and microannulus, is limited. The model presented in this study relies on flow through a Hele-Shaw cell of varying thickness representing a microannulus. Microannulus thickness data is obtained through experimental data available in the literature. The aim of the model is to determine the flow rate of natural gas through a microannulus of varying thickness and the resulting permeability of the leakage pathways.&amp;lt;/p&amp;gt;
Incorporating Multimodal Sentiments into Conversational Bots for Service Requirement Elicitation (2021)

In recent years, task-oriented conversational AI Bots have become very popular in many work and life scenarios with the goal of elicit and satisfy user requirements/intentions by natural language based interactions. To capture user intentions accurately, it is important to design efficient dialog strategy for guiding users to express their intentions by limited rounds of dialogue. However, intention acquisition methods based solely on semantics analysis do not work well especially for those complex user requirements/intentions. In this work, we design a conversational AI bot that could capture user intentions based on multimodal information including video, audio and texts. The bot could incorporate sentiments that are extracted from multimodal information into the bot's dialogue strategy. Sentiments are used for dynamically adjusting the questioning tactics during the dialogue. We design controlled experiments to explore the effectiveness of incorporating multimodal sentiments into the process of guiding users to expressing their intentions. Volunteers are asked to talk with the conversational AI Bot with rich emotions in real application scenarios. Experimental results show that our proposed approach could effectively improve the accuracy of user intention recognition and increase user satisfaction during dialogue. This work lays a solid foundation for the future's service solution design which is a key step in Service-Oriented Systems Engineering (SOSE).
IL-12 Gene Therapy Using an Electrically Mediated Nonviral Approach Reduces Metastatic Growth of Melanoma (2003)

Interleukin-12 (IL-12) has been evaluated in both preclinical and clinical immunotherapy protocols as a potential therapy for melanoma. However, delivery of IL-12 in the form of recombinant protein can result in severe toxicity, and gene therapy has had limited success against B16.F10 murine melanoma. This study investigated the therapeutic effect of delivering a plasmid encoding IL-12 followed by electroporation on primary and secondary tumors. Three treatments of intratumoral (i.t.) plasmid injection and electroporation resulted in 80% of mice with B16.F10 melanoma tumors being tumor free for >100 days (cure). The "cured animals" were resistant to challenge with B16 cells. In a separate experiment, B16 cells were injected on the opposite flank of the treated tumor on the day of treatment. Eighty-seven percent of control mice developed a distant tumor while only 43.8% of mice receiving two or three i.t. electroporation treatments developed a distant tumor. For examination of tumor development in the lungs, mice were injected intravenously with B16.F10 cells then treated with i.m. injections of plasmid with or without electroporation. Only 37.5% of mice receiving i.m. injections and electroporation developed nodules in the lungs compared to 87.5% of mice in the no-treatment group. The results show that administration of a plasmid encoding IL-12 with electroporation has a therapeutic effect on primary tumors as well as distant tumors and metastases.
L-Sox5 and Sox6 Proteins Enhance Chondrogenic miR-140 MicroRNA Expression by Strengthening Dimeric Sox9 Activity (2012)

Sox9 plays a critical role in early chondrocyte initiation and promotion as well as repression of later maturation. Fellow Sox family members L-Sox5 and Sox6 also function as regulators of cartilage development by boosting Sox9 activation of chondrocyte-specific genes such as Col2a1 and Agc1; however, the regulatory mechanism and other target genes are largely unknown. MicroRNAs are a class of short, non-coding RNAs that act as negative regulators of gene expression by promoting target mRNA degradation and/or repressing translation. Analysis of genetically modified mice identified miR-140 as a cartilage-specific microRNA that could be a critical regulator of cartilage development and homeostasis. Recent findings suggest Sox9 promotes miR-140 expression, although the detailed mechanisms are not fully understood. In this study we demonstrate that the proximal upstream region of pri-miR-140 has chondrogenic promoter activity in vivo. We found an L-Sox5/Sox6/Sox9 (Sox trio) response element and detailed binding site in the promoter region. Furthermore, detailed analysis suggests the DNA binding and/or transactivation ability of Sox9 as a homodimer is boosted by L-Sox5 and Sox6. These findings provide new insight into cartilage-specific gene regulation by the Sox trio.
The Human Microbiome Project: A Community Resource for the Healthy Human Microbiome (2012)

This manuscript describes the NIH Human Microbiome Project, including a brief review of human microbiome research, a history of the project, and a comprehensive overview of the consortium's recent collection of publications analyzing the human microbiome.