gebhart/patrepeval huggingface dataset:
microRNA regulatory circuits in a mouse model of inherited retinal degeneration (2016)

miRNA dysregulation is a hallmark of many neurodegenerative disorders, including those involving the retina. Up-regulation of miR-1/133 and miR-142, and down-regulation of miR-183/96/182 has been described in the RHO-P347S mouse retina, a model for a common form of inherited blindness. High-throughput LC-MS/MS was employed to analyse the protein expression of predicted targets for these miRNAs in RHO-P347S mouse retinas; 133 potential target genes were identified. Pathway over-representation analysis suggests G-protein signaling/visual transduction, and synaptic transmission for miR-1, and transmembrane transport, cell-adhesion, signal transduction and apoptosis for miR-183/96/182 as regulated functions in retina. Validation of miRNA-target mRNA interactions for miR-1, miR-96/182 and miR-96 targeting Ctbp2, Rac1 and Slc6a9, respectively, was demonstrated in vitro. In vivo interaction of miR-183/96/182 and Rac1 mRNA in retina was confirmed using miR-CATCH. Additional miRNAs (including miR-103-3p, miR-9-5p) were both predicted to target Rac1 mRNA and enriched by Rac1-miR-CATCH. Other Rac1-miR-CATCH-enriched miRNAs (including miR-125a/b-5p, miR-378a-3p) were not predicted to target Rac1. Furthermore, levels of ~25% of the retinal Rac1 interactors were determined by LC-MS/MS; expression of Rap1gds1 and Cav1 was elevated. Our data suggest significant utilisation of miRNA-based regulation in retina. Possibly more than 30 miRNAs interact with Rac1 in retina, targeting both UTRs and coding regions.
Proteomics Standards Initiative Extended FASTA Format (2019)

Mass-spectrometry-based proteomics enables the high-throughput identification and quantification of proteins, including sequence variants and post-translational modifications (PTMs) in biological samples. However, most workflows require that such variations be included in the search space used to analyze the data, and doing so remains challenging with most analysis tools. In order to facilitate the search for known sequence variants and PTMs, the Proteomics Standards Initiative (PSI) has designed and implemented the PSI extended FASTA format (PEFF). PEFF is based on the very popular FASTA format but adds a uniform mechanism for encoding substantially more metadata about the sequence collection as well as individual entries, including support for encoding known sequence variants, PTMs, and proteoforms. The format is very nearly backward compatible, and as such, existing FASTA parsers will require little or no changes to be able to read PEFF files as FASTA files, although without supporting any of the extra capabilities of PEFF. PEFF is defined by a full specification document, controlled vocabulary terms, a set of example files, software libraries, and a file validator. Popular software and resources are starting to support PEFF, including the sequence search engine Comet and the knowledge bases neXtProt and UniProtKB. Widespread implementation of PEFF is expected to further enable proteogenomics and top-down proteomics applications by providing a standardized mechanism for encoding protein sequences and their known variations. All the related documentation, including the detailed file format specification and example files, are available at http://www.psidev.info/peff .
Model-Based Control of Glass Melting Furnaces and Forehearths: First Principles-Based Model of Predictive Control System Design (2008)

The volume of the Ceramic Engineering and Science Proceeding (CESP) series, in which this paper is incorporated, contains a collection of papers dealing with issues in both traditional ceramics (i.e., glass, whitewares, refractories, and porcelain enamel) and advanced ceramics. Topics covered in the area of advanced ceramic include bioceramics, nanomaterials, composites, solid oxide fuel cells, mechanical properties and structural design, advanced ceramic coatings, ceramic armor, porous ceramics, and more.
ROS‐Responsive N‐Alkylaminoferrocenes for Cancer‐Cell‐Specific Targeting of Mitochondria (2018)

Abstract Mitochondrial membrane potential is more negative in cancer cells than in normal cells, allowing cancer targeting by delocalized lipophilic cations (DLCs). However, as the difference is rather small, these drugs affect also normal cells. Now a concept of pro‐DLCs is proposed based on an N‐alkylaminoferrocene structure. These prodrugs are activated by the reaction with reactive oxygen species (ROS) forming ferrocenium‐based DLCs. Since ROS are overproduced in cancer, the high‐efficiency cancer‐cell‐specific targeting of mitochondria could be achieved as demonstrated by fluorescence microscopy in combination with two fluorogenic pro‐DLCs in vitro and in vivo. We prepared a conjugate of another pro‐DLC with a clinically approved drug carboplatin and confirmed that its accumulation in mitochondria was higher than that of the free drug. This was reflected in the substantially higher anticancer effect of the conjugate.
An old satellite antenna measured on a new test facility at Eindhoven University of Technology (2016)

Results are presented of planar near-field (NF) antenna measurements at Eindhoven University of Technology (TU=e). The antenna under test (AUT) is an engineering model (EM) of a satellite antenna for European coverage from Geostationary Orbit (GEO). It has a shaped beam with Polarisation isolation to allow frequency reuse in a front-fed reflector configuration. Electrical and mechanical axis are not co-incident, making alignment procedures important. A prime reason for publication is that acceptable results can already be obtained with a relatively small NF scan-plane. A comparison is shown with results obtained 25 years ago. It shows also that the AUT with its composite reflector has been kept in a stabile state.
Epoxyharz‐Ester (1955)

Abstract Durch Veresterung von Epoxyharzen mit organischen Säuren gelangt man zu Produkten, die auf dem Anstrichmittel‐Sektor besondere Bedeutung haben. Die Faktoren, welche die Eigenschaften dieser Ester beeinflussen sowie die Anwendungsgebiete der Produkte werden ausführlich besprochen.
Choline Supplementation With a Structured Lipid in Children With Cystic Fibrosis (2015)

LXS had improved choline intake, plasma choline status, and muscle choline stores compared with placebo group. The choline-rich supplement was safe, accepted by participants, and improved choline status in children with CF.
The ablation rate measurements of metal targets in laser marking using double beam irradiation including Q-SW Nd:YAG and CW-CO{sub 2} laser (2010)

Complete text of publication follows. Several experiments were performed to enhance the ablation rate on the gold samples, using simultaneous exposure due to a 100 W CW-CO{sub 2} laser and a Q-switched Nd:YAG laser (40 mJ/pulse, 10 ns, 20 Hz) having similar focal areas (0.2 mm{sup 2}). At first, CO{sub 2} laser thermally increases the bulk temperature up to 800 deg C before the application of Nd:YAG laser shots to preheat the surface. This changes the thermal and optical properties of the target leading to a greater energy coupling. In fact, there is a significant addition of sensible energy to the system which does not have to be supplied by the pulsed laser to heat plasma. Moreover, during the pulsed laser exposure, the inverse Bremsstrahlung contributes to reheat plasma due to the strong absorption cross section at the longer wavelength (10.6 {mu}m), as a subsidiary effect. It significantly enhances the ablation rate respect to the single beam irradiation.
SEPT - Improving JSECST/ECSAMS in concert with the ATS framework (2007)

The AN/USM-670 Joint Services Electronic Combat Systems Tester (JSECST) is the current standard in Electronic Combat (EC) system flight line level test -supporting a wide variety of EC systems across multiple platforms. The Electronic Combat Stimulus and Measurement System (ECSAMS) is a JSECST-compatible product designed to support vertical testing of EC systems across multiple levels of test.
Supplemental Table 3 from Elevated V–ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer (2023)

&lt;p&gt;Sequence of qPCR, siRNA, and shRNA used&lt;/p&gt;
Personalised hypermedia presentation techniques for improving online customer relationships (2001)

This article gives a comprehensive overview of techniques for personalised hypermedia presentation. It describes the data about the computer user, the computer usage and the physical environment that can be taken into account when adapting hypermedia pages to the needs of the current user. Methods for acquiring these data, for representing them as models in formal systems and for making generalisations and predictions about the user based thereon are discussed. Different types of hypermedia adaptation to the individual user's needs are distinguished and recommendations for further research and applications given. While the focus of the article is on hypermedia adaptation for improving customer relationship management utilising the World Wide Web, many of the techniques and distinctions also apply to other types of personalised hypermedia applications within and outside the World Wide Web, like adaptive educational systems.
Anodic Oxidation of Impure  H 2 on Teflon‐Bonded Pt ‐ Ru /  WO 3 /  C  Electrodes (1995)

A series of carbon supported electrocatalysts, Pt/C, , Pt‐Ru/C, and , were prepared by freeze drying and tested as Teflon‐bonded electrodes in 0.5M in a stream of impure hydrogen containing 100 ppm of CO at 80°C. The first three catalysts were gradually poisoned and the performance was less than 100 mA/cm2 at 200 mV vs. SHE. However, there was no change in the performance of the Teflon‐bonded electrode at 220 mA/cm2 over a test period of 6 h.
Darstellung und Molekülstruktur von Tris(dimethyldithiocarbamato)aluminium, eine Verbindung mit hexakoordiniertem Aluminium (1983)

Abstract Al(NR 2 ) 3 und ClAl(NR 2 ) 2 (R = CH 3 ) addieren CS 2 unter Bildung der Dimethyldithiocarbamate 1 und 2 , von denen 1 in Benzol monomer, 2 hingegen dimer löslich ist. 27 Al‐NMR‐Daten weisen hexakoordinierte Al‐Atome aus, die durch die Röntgenstrukturanalyse von 1 bestätigt werden: das Al‐Atom ist verzerrt trigonal antiprismatisch von sechs Schwefelatomen umgeben. Die C 2 NCS 2 ‐Gruppen sind planar. Für 2 folgt eine Struktur mit zwei brückenständigen Cl‐Atomen, jeweils vier S‐Atome ergänzen zur Hexakoordination der zwei Al‐Atome im Molekül.
Supplementation of 1-Kestose Modulates the Gut Microbiota Composition to Ameliorate Glucose Metabolism in Obesity-Prone Hosts (2021)

Insulin resistance leads to the onset of medical conditions such as type 2 diabetes, and its development is associated with the alteration in the gut microbiota. Although it has been demonstrated that supplementation with prebiotics modulates the gut microbiota, limited evidence is available for effects of prebiotics on insulin resistance, especially for humans. We investigated the prebiotic effect of 1-kestose supplementation on fasting insulin concentration in obesity-prone humans and rats. In the preliminary study using rats, the hyperinsulinemia induced by high-fat diet was suppressed by intake of water with 2% (<i>w</i>/<i>v</i>) 1-kestose. In the clinical study using obese-prone volunteers, the fasting serum insulin level was significantly reduced from 6.5 µU/mL (95% CI, 5.5-7.6) to 5.3 (4.6-6.0) by the 12-week intervention with supplementation of 10 g 1-kestose/day, whereas it was not changed by the intervention with placebo (6.2 µU/mL (5.4-7.1) and 6.5 (5.5-7.6) before and after intervention, respectively). The relative abundance of fecal <i>Bifidobacterium</i> was significantly increased to 0.3244 (SD, 0.1526) in 1-kestose-supplemented participants compared to that in control participants (0.1971 (0.1158)). These results suggest that prebiotic intervention using 1-kestose may potentially ameliorate insulin resistance in overweight humans via the modulation of the gut microbiota. UMIN 000028824.
Supplementary Figure from Combination Therapy with Vidaza and Entinostat Suppresses Tumor Growth and Reprograms the Epigenome in an Orthotopic Lung Cancer Model (2023)

Supplementary Figure from Combination Therapy with Vidaza and Entinostat Suppresses Tumor Growth and Reprograms the Epigenome in an Orthotopic Lung Cancer Model
A 1.6Gbps Digital Clock and Data Recovery Circuit (2006)

A digital clock and data recovery circuit employs simple 3-level digital-to-analog converters to interface the digital loop filter to the voltage controlled oscillator and achieves low jitter performance. Test chip fabricated in a 0.13mum CMOS process achieves BER < 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12 </sup> , plusmn1500ppm lock-in range, plusmn2500ppm tracking range, recovered clock jitter of 8.9ps rms and consumes 12mW power from a single-pin 1.2V supply, while operating at 1.6Gbps
CD4+ and CD8+ Lymphocytes of Patients with AIDS Synthesize Increased Amounts of Interferon-γ (1995)

Individual cells capable of interferon-gamma (IFN-gamma) synthesis are easily detected by immunofluorescence and flow cytometric analysis using an anti-IFN-gamma monoclonal antibody as specific reagent. By IFN-gamma flow cytometry assay, we demonstrated that HIV-seropositive patients, starting at the early stage of viral infection, generally have an increased percentage of lymphocytes potentially able to produce IFN-gamma, compared with healthy blood donors. IFN-gamma expression in patient lymphocytes was observed to increase with the progressive stages of HIV infection, with the highest figures occurring in stage C patients. Such increased IFN-gamma expression involved both CD4+ and CD8+ T cell subsets. Most interestingly, we found patients at the same stage of HIV infection who had similar numbers of total and CD4+ lymphocytes but highly different percentages of lymphocytes potentially capable of producing IFN-gamma.
Highly suppressed boron penetration in NO-nitrided SiO/sub 2/ for p/sup +/-polysilicon gated MOS device applications (1995)

In this paper, we demonstrate the superior diffusion barrier properties of NO-nitrided SiO/sub 2/ in suppressing boron penetration for p/sup +/-polysilicon gated MOS devices. Boron penetration effects have been studied in terms of flatband voltage shift, decrease in inversion capacitance (due to polysilicon depletion effect), impact on interface state density, and charge-to-breakdown. Results show that NO-nitrided SiO/sub 2/, as compared to conventional thermal SiO/sub 2/, exhibits much higher resistance to boron penetration, and therefore, is very attractive for surface channel PMOS technology.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Immune Suppression in vivo with Antigen-Modified Syngeneic Cells (1979)

Abstract Intravenous administration of syngeneic spleen cells coupled with the palmitoyl derivative of fowl γ-globulin (p-FγG) results in a profound state of FγG-specific tolerance in C57BL/6 mice. Administration of p-FγG coupled syngeneic cells specifically reduces both the primary and secondary hapten and carrier-specific PFC responses to TNP-FγG. Since the haptenic response is affected, the tolerance functions at the level of the FγG-specific helper T cell. As few as 103 p-FγG spleen cells carrying only 1 ng of p-FγG can induce tolerance. At least a 2-day-induction period is required. This nonresponsiveness is long lived, lasting over 120 days. Spleen cells from tolerized mice can transfer suppression to normal syngeneic recipients. Treatment of tolerant spleens with anti-Thy 1.2 antiserum + C eliminates the suppressor cell activity. In addition, thymocytes and purified splenic T cells from tolerized mice can transfer suppression to normal recipients. Thus, at least a component of this nonresponsiveness is mediated by suppressor T cells. The requirement of antigen association with cell membrane components and the general applicability of this method of inducing T cell nonresponsiveness are discussed.
3-bromomethyl-propyphenazone as a new derivatization reagent for high performance liquid chromatography of captopril and hydrochlorothiazide with UV-detection (1998)

3-Bromomethyl-propyphenazone (BMP) was used as a derivatization reagent for the detection and quantification of captopril (CAP) and hydrochlorothiazide (HCT) by high performance liquid chromatography using Zorbax C8 column, and 0.05M sodium acetate, acetonitrile, methanol (14:17:4; pH 6.5) as mobile phase system with UV-detection at 254 nm. The cited reagent reacts with the mercapto and amino groups of CAP and HCT in acetone using anhydrous potassium carbonate as hydrobromide acceptor. The reaction was completed within 30 min for CAP and 60 min for HCT with heating at 105 +/- 5 degrees C in mini-reaction vial. The linear concentration ranges for both CAP and HCT were 8 to 160 and 6 to 140 ng per injection, respectively. The derivatized captopril was synthesized and confirmed with spectral analysis. This method was applied for determination of spiked captopril in human urine after extraction with Extrelut-20 column using ethyl acetate:isopropanol (85:15 v/v) as eluant.
Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells (2001)

The saponin digitonin, the aglycone digitoxigenin and five cardiac glycosides were evaluated for cytotoxicity using primary cultures of tumor cells from patients and a human cell line panel (representing different cytotoxic drug-resistance patterns). Of these seven compounds, proscillaridin A was the most potent (IC(50): 6.4--76 nM), followed by digitoxin, and then ouabain, digoxin, lanatoside C, digitoxigenin and digitonin. Correlation analysis of the log IC(50) values for the cell lines in the panel showed that compound cytotoxicity was only slightly influenced by resistance mechanisms that involved P-glycoprotein, topoisomerase II, multidrug resistance-associated protein and glutathione-mediated drug resistance. Digitoxin and digoxin expressed selective toxicity against solid tumor cells from patients, while proscillaridin A expressed no selective toxicity against either solid or hematological tumor cells. The results revealed marked differences in cytotoxicity between the cardiac glycosides, both in potency and selectivity, and modes of action for cytotoxicity that differ from that of commonly used anticancer drugs.
Package Localization in a Warehouse Environment by Means of RFID (2010)

Abstract This paper reviews how RFID-assisted geometry recognition can compete conventional methods for automated package handling. It demonstrates how RFID tags used for product identification can be implemented into automated handling processes to improve warehousing efficiency. Therefore, tag positioning for the HF band is investigated based on two distinct localization principles and different RFID systems. RFID-assisted package localization and positioning is discussed based on the results and the impact it could have on warehouse automation and other industrial applications.
Exploiting Music and Dance Notation to Improve Visualization of Data in BIM (2019)

Suboptimal information sharing is a key a factor that negatively impacts the construction sector’s massive productivity gap when compared to other sectors of the economy. This is due to management difficulties, supply chain issues, and rework. Building information modeling has been shown to improve dissemination of information but has not yet been exploited to its full potential. In this paper, we propose a new notation for visualizing project information in a BIM context. It is inspired by music and dance notation, and is designed to overcome current limitations that may cause the technology’s limited use during the construction phase. A proof of concept was implemented and tested in an experiment with stakeholders. The use of the proposed BIM notations appeared to make access to and interpretation of available data more effective and resulted in more correct responses.
Designing a Robust Kelvin Probe Setup Optimized for Long-Term Surface Photovoltage Acquisition (2018)

We introduce a robust low-budget Kelvin probe design that is optimized for the long-term acquisition of surface photovoltage (SPV) data, especially developed for highly resistive systems, which exhibit-in contrast to conventional semiconductors-very slow photoinduced charge relaxation processes in the range of hours and days. The device provides convenient optical access to the sample, as well as high mechanical and electrical stability due to off-resonance operation, showing a noise band as narrow as 1 mV. Furthermore, the acquisition of temperature-dependent SPV transients necessary for SPV-based deep-level transient spectroscopy becomes easily possible. The performance of the instrument is demonstrated by recording long-term SPV transients of the ultra-slowly relaxing model oxide strontium titanate (SrTiO 3 ) over 20 h.
Sublithographic nanofabrication technology for nanocatalysts and DNA chips (2003)

We describe parallel processes for nanometer pattern generation on a wafer scale with resolution comparable to the best electron beam lithography. Sub-10 nm linewidth is defined by a sacrificial ultrathin film deposited by low pressure chemical vapor deposition (LPCVD), in a process similar to formation of gate sidewall spacers in CMOS processing. We further demonstrate a method called iterative spacer lithography (ISL), in which the process is repeated multiple times with alternating materials in order to multiply the pattern density. Silicon structures with sub-10 nm width fabricated by this process were used as a mold in nanoimprint lithography and lift-off patterning of sub-30 nm platinum nanowires for use in experiments on chemical catalysis. We also demonstrate a similar process called reversed spacer lithography (RSL) to form sub-10 nm fluid channels in poly-Si. This nanogap fluid channel device was used for label-free detection of DNA hybridization based on electrical sensing of dielectric changes in the gap.
Hydrologic assessment of blind inlet performance in a drained closed depression (2020)

Surface inlets installed in agricultural closed depressions can transport sediment- and nutrient-laden runoff directly to receiving streams or water bodies. Replacing tile risers with blind inlets has the potential to decrease these sediment and nutrient loads, but adoption of blind inlets has been met with hesitation from producers who fear that changes to the surface inlet may result in additional water ponding, crop damage, or crop loss. The objectives of this study were to assess hydrologic performance of blind inlets over time, and to determine whether blind inlets influenced the hydrology of a closed depression compared to a tile riser. Hydrograph characteristics including flow duration, time to peak flow, peak flow rate, and cumulative flow were evaluated for 549 storm events over a 12-year period (2006 to 2017) for a pair of closed depressions in northeastern Indiana. Surface water could be drained in both depressional areas with either a tile riser or blind inlet. Results showed that blind inlet infiltration rates declined approximately linearly over time (1.4 cm h<sup>−1</sup> y<sup>−1</sup>). While changes in infiltration were largely controlled by annual tillage practices at the study sites, findings suggest that blind inlets have an effective service life of 8 to 10 years under the study conditions. Surface water management practices significantly influenced depression hydrology; however, the practices functioned differently between fields. Blind inlets did not influence the frequency of discharge, but they may increase or decrease the duration of flow and cumulative flow compared to a tile riser depending on the extent of subsurface tile drainage within the closed depression. Findings from this study underscore the inherent connections between surface and subsurface hydrologic processes in drained closed depressions and how these connections may influence both water quantity and water quality.