gebhart/patrepeval huggingface dataset:
Tumor gene therapy by systemic delivery of plasmid DNA with cell‐penetrating peptides (2018)

Gene therapy is a prospective strategy for treating cancer. However, finding efficient and tumor-specific gene delivery vectors remains an issue. Tumor responsive cell-penetrating peptide (CPP) PepFect144 (PF144) has previously been shown to deliver reporter gene encoding plasmid DNA specifically into tumors upon systemic administration, but its capability to reduce tumor growth has not yet been evaluated. Here, we study the potential of PF144-based anti-angiogenic gene delivery to inhibit tumor growth by silencing vascular endothelial growth factor (VEGF) expression in tumors. This approach led to the inhibition of tumor growth in both the HT1080 fibrosarcoma model and orthotopic 4T1 breast tumor model. We additionally saw that the addition of αvβ3 integrin targeting did not further improve the tumor sensitive CPPs. Our results suggest that activatable cell-penetrating peptide PF144 is a promising nonviral plasmid DNA delivery vector for cancer treatment.
Unleashing meiotic crossovers in hybrid plants (2017)

Meiotic crossovers shuffle parental genetic information, providing novel combinations of alleles on which natural or artificial selection can act. However, crossover events are relatively rare, typically one to three exchange points per chromosome pair. Recent work has identified three pathways limiting meiotic crossovers in Arabidopsis thaliana , that rely on the activity of FANCM 1 , RECQ4 2 and FIGL1 3 , respectively. Here, we analyzed recombination in plants where one, two or three of these pathways were disrupted, in both pure line and hybrid contexts. The highest effect was observed when combining recq4 and figl1 mutations, which increased the hybrid genetic map length from 389 to 3037 centiMorgans. This corresponds to an unprecedented 7.8-fold increase in crossover frequency. Disrupting the three pathways do not further increases recombination, suggesting that some upper limit has been reached. The increase in crossovers is not uniform along chromosomes and rises from centromere to telomere. Finally, while in wild type recombination is much higher in male than in female meiosis (490 cM vs 290 cM), female recombination is higher than male in recq4 figl1 (3200 cM vs 2720 cM), suggesting that the factors that make wild-type female meiosis less recombinogenic than male wild-type meiosis do not apply in the mutant context. The massive increase of recombination observed in recq4 figl1 hybrids opens the possibility to manipulate recombination to enhance plant breeding efficiency.
Facile Synthesis of N-Tosyl Aza-Baylis-Hillman Adducts of Acrylamide via a Pd-Catalyzed Hydration of Nitrile to Amide (2010)

Pd(OAc) 2 (10%), PPh 3 (20%) aqueous EtOH, reflux, 3 h (
Nicotine in E-cigarette smoke: cancer culprit? (2019)

Tobacco smoke's harmful effects are well-known; the harmful effects of tobacco smoke have been well-investigated. Nicotine in tobacco smoke contributes to the pathogenesis of various conditions, such as lung cancer, coronary artery disease and asthma. A decade ago, a seemingly safer alternative to tobacco cigarettes was introduced- the E-cigarette. However, studies have found that E-cigarette smoke (ECS) not only induces DNA damage but also reduces DNA repair activity via BER and NER pathways. Further research conducted with cells damaged by Ultra-Violet (UV) light or hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) indicates that ECS can function as a comutagen; nicotine can amplify mutagenic activity by merging with other mutagens. The downstream metabolites derived from nicotine found in ECS put E-cigarette smokers at a higher risk for developing lung or bladder cancers or heart disease than their non-smoking counterparts. Overall, these findings are instrumental in our understanding of the harmful effects of ECS.
ICONE23-1748 JSFR DESIGN PROGRESS RELATED TO DEVELOPMENT OF SAFETY DESIGN CRITERIA FOR GENERATION IV SODIUM-COOLED FAST REACTORS : (2) PROGRESS OF SAFETY DESIGN (2015)

To meet the safety design criteria (SDC) and contributing to the establishment of the safety design guideline (SDG) for a Generation-IV Sodium-cooled fast reactor (SFR), the heat removal function of JSFR was enhanced to avoid loss of the function even if any internal events exceeding design bases or severe external events happen. As a countermeasure against loss of reactor level (LORL) type event, double failure of reactor vessel (RV) and guard vessel (GV) is prevented by securing a margin to earthquake resistant performance and a reliability of RV and GV. Furthermore, direct reactor auxiliary cooling system (DRACS) is extended functionally to keep heat removal capability even if siphon break occurs by multiple leakages on the primary cooling circuit. Against loss of heat sink (LOHS) type event, effective measures are enhancement of natural circulation function of DRACS and primary reactor auxiliary cooling system (PRACS), application of accident management and introduction of auxiliary core cooling system independent from DRACS and PRACS to prevent loss of all heat removal function from severe external events. It is important that RV melt-through can be practically eliminated by these design measure to achieve in-vessel retention (IVR) without significant core damage in the loss of heat removal type events.
Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding (1998)

NSAIDs reduce HMB when compared with placebo but are less effective than either tranexamic acid or danazol. However, adverse events are more severe with danazol therapy. In the limited number of small studies suitable for evaluation, no significant difference in efficacy was demonstrated between NSAIDs and other medical treatments such as oral luteal progestogen, ethamsylate, OCC or IUS.
Charge-transfer complexation and photoreduction of viologen derivatives bearing the para-substituted benzophenone group in dimethyl sulfoxide (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharge-transfer complexation and photoreduction of viologen derivatives bearing the para-substituted benzophenone group in dimethyl sulfoxideChiho Tanaka, Yoko Nambu, and Takeshi EndoCite this: J. Phys. Chem. 1992, 96, 17, 7018–7021Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/j100196a032https://doi.org/10.1021/j100196a032research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts (2011)

The transition from quiescence to proliferation is a key regulatory step that can be induced by serum stimulation in cultured fibroblasts. The transcription factor Myc is directly induced by serum mitogens and drives a secondary gene expression program that remains largely unknown. Using mRNA profiling, we identify close to 300 Myc-dependent serum response (MDSR) genes, which are induced by serum in a Myc-dependent manner in mouse fibroblasts. Mapping of genomic Myc-binding sites by ChIP-seq technology revealed that most MDSR genes were directly targeted by Myc, but represented a minor fraction (5.5%) of all Myc-bound promoters (which were 22.4% of all promoters). Other target loci were either induced by serum in a Myc-independent manner, were not significantly regulated or were negatively regulated. MDSR gene products were involved in a variety of processes, including nucleotide biosynthesis, ribosome biogenesis, DNA replication and RNA control. Of the 29 MDSR genes targeted by RNA interference, three showed a requirement for cell-cycle entry upon serum stimulation and 11 for long-term proliferation and/or survival. Hence, proper coordination of key regulatory and biosynthetic pathways following mitogenic stimulation relies upon the concerted regulation of multiple Myc-dependent genes.
Continuous monitoring of hemorrhagic brain strokes via contrast source inversion (2017)

We consider the differential microwave imaging for continuous monitoring of hemorrhagic brain strokes where our aim is to determine the change of bleeding in sequential time frames. The scattered electromagnetic field is measured in two different time steps, and the difference in the scattered field is used as the data of the inversion scheme. The imaging is performed via contrast source inversion. However, since the data of the inversion scheme consists of the difference of the scattered field measurements, the algorithm produces a differential contrast function instead of a complete reconstruction. This function carries information about the difference in the electromagnetic parameters of the brain, that is the relative size of the blood region, between two measurements. The numerical simulations with a realistic head model demonstrate that the method is capable of detecting changes in multiple blood regions, and provides information about the locations and the types of these changes.
Electromagnetically coupled rectangular patch antenna for L-band operation: FDTD modeling (2004)

Electromagnetically Coupled Patch Antenna (EMCP) appeared to be first discussed by Sabban [1]-[2] and since then it has been under careful investigations [3]-[9] because of its broadband operation together with simple structure. For example, Lee et al[3]-[5] experimented the effects of the parasitic patch sizes, dielectric superstartes and the distance between the patches on the behavior of the antenna very carefully. The conventional structure for EMCP is shown in Fig 1. In this paper a new designed structure for L-band operation is investigated using the finite-difference time-domain (FDTD) technique. A fairly accurate model for coaxial probe fed is applied and the simulated input impedance and radiation patterns are compared with the measured results.
Allergy—A New Role for T Cell Superantigens of Staphylococcus aureus? (2020)

<i>Staphylococcus aureus</i> superantigens (SAgs) are among the most potent T cell mitogens known. They stimulate large fractions of T cells by cross-linking their T cell receptor with major histocompatibility complex class-II molecules on antigen presenting cells, resulting in T cell proliferation and massive cytokine release. To date, 26 different SAgs have been described in the species <i>S. aureus</i>; they comprise the toxic shock syndrome toxin (TSST-1), as well as 25 staphylococcal enterotoxins (SEs) or enterotoxin-like proteins (SEls). SAgs can cause staphylococcal food poisoning and toxic shock syndrome and contribute to the clinical symptoms of staphylococcal infection. In addition, there is growing evidence that SAgs are involved in allergic diseases. This review provides an overview on recent epidemiological data on the involvement of <i>S. aureus</i> SAgs and anti-SAg-IgE in allergy, demonstrating that being sensitized to SEs-in contrast to inhalant allergens-is associated with a severe disease course in patients with chronic airway inflammation. The mechanisms by which SAgs trigger or amplify allergic immune responses, however, are not yet fully understood. Here, we discuss known and hypothetical pathways by which SAgs can drive an atopic disease.
MICRON~RESOLUTION BIOMEDICAL IMAGING WITH OPTICAL COHERENCE TOMOGRAPHY (1993)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text JOSEPH A. IZATT, MICHAEL R. HEE, DAVID HUANG, ERIC A. SWANSON, CHARLES P. LIN, JOEL S. SCHUMAN, CARMEN A. PULIAFITO, and JAMES G. FUJIMOTO, "MICRON~RESOLUTION BIOMEDICAL IMAGING WITH OPTICAL COHERENCE TOMOGRAPHY," Optics & Photonics News 4(10), 14-19 (1993) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Stochastic Modeling of Incident Gust Effects on Aerodynamic Lift (2010)

The intrusive formulation of polynomial chaos expansion is implemented to determine uncertainty in aerodynamic loads on a rigid airfoil due to imprecise parameters that characterize an incoming gust. The results yield the sensitivity of the lift coefficient to variations in intensities and integral length scales of the gust fluctuations. The results show that lift coefficient fluctuations about the mean of each time step are affected primarily by the intensity ofthe fluctuations of the vertical velocity component, which should be expected. Next in order of importance is the integral length scale of the vertical velocity component. This implementation of the intrusive polynomial chaos expansion provides guidance for future efforts to quantify uncertain gust loads on micro air vehicles with higher fidelity models.
Improvement of amphotericin B activity during experimental cryptococcosis by incorporation into specific immunoliposomes (1990)

Cryptococcosis is an opportunistic infection that is responsible for increased morbidity and mortality in patients with the acquired immunodeficiency syndrome. The high toxicity of the antifungal agent that is mainly used against cryptococcosis, amphotericin B (AMB), accounts for the need for new treatments, especially in patients with the acquired immunodeficiency syndrome because of the high relapse rate of cryptococcosis. Drug targeting may be one of these alternate treatments. Since we have demonstrated that an immunoglobulin G1 (IgG1) anti-Cryptococcus neoformans serotype A monoclonal antibody (E1) was protective during experimental cryptococcosis in mice, we investigated whether specific targeting of AMB with liposomes that bear E1 would improve the therapeutic index of the drug. For that purpose, in vitro and in vivo experiments were designed to compare the specificities and activities of these liposomes with those of control immunoliposomes bearing a nonrelated IgG1 monoclonal antibody (CY34). The immunoliposomes were prepared by covalently linking E1 or CY34 and small unilamellar vesicles. When immunoliposomes were incubated with yeast cells, only E1-bearing liposomes recognized C. neoformans. In vivo, mice that were treated 24 h after infection with one injection of AMB (0.12 mg/kg of body weight) intercalated into E1-bearing liposomes survived significantly longer than did those given the same dose of AMB alone or AMB intercalated into nontargeted liposomes or control immunoliposomes. None of the mice that were given control treatments did statistically better than those that were given AMB. Keeping in mind that this kind of therapy requires knowledge of the antigenic type of the infecting organism, the results suggest that specific targeting of small doses of AMB improve the efficacy of AMB and might be an alternative to the use of larger doses of AMB.
A batchmode dynamic scheduling scheme for cloud computing (2015)

Cloud computing is an emerging technology, so far standing outright, creating challenges for developers and techies who work in the system as well as to the research and development concerns for both commercial and organizational purposes. Staying subversive in all its research and development it creates a lot of real time issues for both technical and noncommercial users at different levels, which has to be fixed. All the real time computation dependent fields started relying on the cloud computing. The service providers have also started providing the cloud computing environment as a commercial one to all the end users present. So it becomes sensible and certain to fix even small issues that occur in a computing environment which is being used by millions of people, that supports millions of transactions a day. In this paper, taking the context of resource provisioning, scheduling is considered as the issue. This paper discuss about the various scheduling schemes and ideas with respect to the private cloud environment. A social distribution model named Berger model[15] is being co-related with respect to the general scheduling algorithms and used to overcome the issues in scheduling. This model compares the resource provisioning strategy of the real time economic model to the cloud computing model. This paper analyzes this model considering makespan and bandwidth as the metric and reduce the same, with Berger model and other scheduling algorithm comparatively like Min-Min. Considering and evaluating all the constraints an efficient dynamic scheduling scheme for the cloud environments is proposed. Cloudsim, a simulation tool is used to simulate the experiment.
Resolution Enhancement Of Color Video (1996)

Publication in the conference proceedings of EUSIPCO, Trieste, Italy, 1996
Durable Antibody Responses Following One Dose of the Bivalent Human Papillomavirus L1 Virus-Like Particle Vaccine in the Costa Rica Vaccine Trial (2013)

The Costa Rica HPV16/18 Vaccine Trial (CVT) showed that four-year vaccine efficacy against 12-month HPV16/18 persistent infection was similarly high among women who received one, two, or the recommended three doses of the bivalent HPV16/18 L1 virus-like particle (VLP) vaccine. Live-attenuated viral vaccines, but not simple-subunit vaccines, usually induce durable lifelong antibody responses after a single dose. It is unclear whether noninfectious VLP vaccines behave more like live-virus or simple-subunit vaccines in this regard. To explore the likelihood that efficacy will persist longer term, we investigated the magnitude and durability of antibodies to this vaccine by measuring HPV16- and HPV18-specific antibodies by VLP-ELISA using serum from enrollment, vaccination, and annual visits through four years in four vaccinated groups; one-dose (n = 78), two-doses separated by one month (n = 140), two doses separated by six months (n = 52), and three scheduled doses (n = 120, randomly selected). We also tested enrollment sera from n = 113 HPV16- or HPV18 L1-seropositive women prevaccination, presumably from natural infection. At four years, 100% of women in all groups remained HPV16/18 seropositive; both HPV16/18 geometric mean titers (GMT) among the extended two-dose group were non-inferior to the three-dose group, and ELISA titers were highly correlated with neutralization titers in all groups. Compared with the natural infection group, HPV16/18 GMTs were, respectively, at least 24 and 14 times higher among the two-dose and 9 and 5 times higher among one-dose vaccinees. Antibody levels following one-dose remained stable from month 6 through month 48. Results raise the possibility that even a single dose of HPV VLPs will induce long-term protection.
Downdating the Latent Semantic Indexing Model for Conceptual Information Retrieval (1998)

Due to the growth of large data collections, information retrieval or database searching is of vital importance. Lexical matching techniques may retrieve irrelevant or inaccurate results because of synonyms and polysemous words, so effective concept-based techniques are needed. One such technique is latent semantic indexing (LSI) which uses a vector-space approach by identifying documents whose content is related to the user's query in order of similarity. LSI uses the singular value decomposition (SVD) of term-by-document matrix to encode the terms and documents in a vector-space model. Existing methods for removing terms or documents from the term-document space are either time consuming or do not sufficiently change the term-document relationships. This paper presents a new method for downdating, downdating the reduced model (or DRM) method, and discusses its implementation into the LSI++ software environment. The DRM method can be used to assess the effect that a term or document has on the clustering of relevant information in a collection and for the incorporation of user feedback in the existing LSI model. Implementing the DRM method within LSI++ not only provides downdating functionality, but is less time consuming than recomputing the SVD when removing a term, document or both. The DRM method is a viable algorithm for dynamic information modeling and retrieval.
Plenary lecture 2: design framework for heterogeneous chip multiprocessing targeting dynamic reconfiguration (2009)

Heterogeneous chip multiprocessors form powerful computing platforms. For high-performance or real-time applications, their design should also rely on acceptable energy budgets. The inclusion of reconfigurable hardware can enhance these platforms even further. This talk first presents a very versatile family of reconfigurable chip multiprocessors that can support the run-time reconfiguration of resources in efforts to match target applications for better performance and/or lower energy consumption. This talk then introduces another family of reconfigurable chip multiprocessors where the hardware can be customized to speed up the execution of time-consuming application kernels. Hardware reconfiguration can then facilitate various customized kernels as execution proceeds. This approach greatly reduces the space and energy requirements, attributes that appeal to high-performance embedded designs. The kernel execution should be prudently scheduled considering the reconfiguration overheads. Suitable task scheduling and resource reconfiguration policies are presented for these families of chip multiprocessors and benchmarks are enlisted as well to showcase their success.
Correlations between plasma levels of an endogenous digitalis-like substance and haemodynamic parameters measured during cardiac catheterization (1988)

It has been postulated that one or more plasma digitalis-like compounds may play an important role in body fluid regulation and in essential hypertension, although very little is known about their possible role in general haemodynamics. We therefore measured plasma inhibition of human kidney Na+,K+-ATPase and plasma cross-reactivity with digoxin antibodies in 11 normotensive cardiopathic subjects admitted to our clinic for heart catheterization. Possible correlations with haemodynamic parameters were studied. Plasma digoxin-like activity correlated directly with left atrial pressure and with pulmonary circulation data. The ability of the plasma to inhibit Na+,K+-ATPase showed an inverse correlation with cardiac output and cardiac index. No correlations were found with any of the other parameters measured, notably systemic resistance, blood pressure and natriuresis. These findings suggest the presence of more than one substance sharing chemical properties with digitalis: (1) a substance cross-reacting with digoxin antibodies and dependent on pulmonary vascular congestion; and (2) a substance capable of inhibiting the Na+-K+ pump and present in large amounts in heart diseases with a reduced cardiac index.
Femtosecond Periodic Gain Vertical-Cavity Semiconductor Lasers (1993)

A periodic gain structure was used as the gain medium in an optically pumped mode-locked vertical-cavity surface-emitting semiconductor laser to decrease the effective carrier lifetime. A laser pulsewidth of under 190 fs was directly generated from die laser cavity.