gebhart/patrepeval huggingface dataset:
An architectural solution for the inductive noise problem due to clock-gating (1999)

Article An architectural solution for the inductive noise problem due to clock-gating Share on Authors: Mondira Deb Pant Georgia Institute of Technology, Atlanta, GA Georgia Institute of Technology, Atlanta, GAView Profile , Pankaj Pant View Profile , D. Scott Wills Georgia Institute of Technology, Atlanta, GA Georgia Institute of Technology, Atlanta, GAView Profile , Vivek Tiwari Intel Corporation, Santa Clara, CA Intel Corporation, Santa Clara, CAView Profile Authors Info & Claims ISLPED '99: Proceedings of the 1999 international symposium on Low power electronics and designAugust 1999 Pages 255–257https://doi.org/10.1145/313817.313938Online:17 August 1999Publication History 42citation309DownloadsMetricsTotal Citations42Total Downloads309Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Localization of noncovalently bound ethidium in free and methionyl-tRNA synthetase bound tRNAfMet by singlet-singlet energy transfer (1986)

Ethidium binds tRNAfMet with 17-fold enhancement in the emission intensity at 600 nm. Fluorescence titration of tRNAfMet with ethidium indicates a single high-affinity site in tRNAfMet with a dissociation constant of 5 microM. Ethidium is apparently rigidly bound to tRNAfMet and effectively shielded from solvent. tRNAfMet(8-13), tRNAfMet(3'-Flc), and tRNAfMet(D-PF) with fluorophores at thiouridine, the 3'-terminus, and dihydrouridine, respectively, are prepared, and the singlet-singlet energy-transfer efficiencies between these fluorophores and noncovalently bound ethidium are determined. The transfer efficiency between bound ethidium and the fluorophore in tRNAfMet(8-13) determined by donor quenching and sensitized emission is the same, strongly suggesting that there is only one bound ethidium per tRNAfMet molecule. The apparent distances between ethidium and various fluorophores including 3'-fluorescein, the 8-13 photo-cross-link, and D-proflavin are 41, 19, and 30 A, respectively, assuming random orientation between the donor and the acceptor. The results suggest that noncovalently bound ethidium is intercalated in the amino acid acceptor stem. In the complex of tRNAfMet and methionyl-tRNA synthetase, the transfer efficiencies for the tRNAfMet(8-13), tRNAfMet(3'-Flc), and tRNAfMet(D-PF) are reduced, enhanced, and little changed, respectively. These methionyl-tRNA synthetase induced changes suggest changes in the conformation of the 3'-terminal unpaired bases and the relative orientation or location between tRNAfMet and ethidium upon binding of methionyl-tRNA synthetase.
XXIII (2009)

<sc>Fanny</sc>On her arrival in town, carried out her second idea, despatching the Colonel to his club for luncheon and pack-ing her maid into a cab, for Cadogan Place, with the variety of their effects. The result of this for each of the pair was...
Hyaluronan contributes to the enlargement of hypertrophic lacunae in the growth plate (1996)

Histochemical staining of the epiphysial growth plate revealed that free hyaluronan (i.e. available to the staining probe) was restricted to the zone of hypertrophy, where it was located in the pericellular space between the chondrocytes and the edge of the lacunae. Furthermore, the amount of hyaluronan staining was directly proportional to the size of the lacunae. Autoradiographic analysis of growth plates cultured with isotopically labeled glucosamine indicated that at least a portion of this hyaluronan was newly synthesized by the hypertrophic chondrocytes. Since hyaluronan can adsorb large amounts of water, it is possible that it exerted a hydrostatic pressure on the surrounding territorial matrix and thereby caused the expansion of hypertrophic lacunae. To assess this possibility, segments of the growth plate were placed in organ culture under different conditions. Under normal culture conditions, a band of hyaluronan staining migrated across the segments coinciding with the enlargement of lacunae in these regions, and the segments, as a whole, increased in size. In contrast, when the segments were cultured in the presence of hyaluronidase, which degraded the pericellular hyaluronan, the lacunae did not undergo enlargement and the overall size of the segments did not increase. These results suggest that the production of hyaluronan contributes to the enlargement of hypertrophic lacunae which is important for determining both the body's stature and proportions.
Value of Free-Run Electromyographic Monitoring of Extraocular Cranial Nerves during Expanded Endonasal Surgery (EES) of the Skull Base (2013)

Objective To evaluate the value of free-run electromyography (f-EMG) monitoring of extraocular cranial nerves (EOCN) III, IV, and VI during expanded endonasal surgery (EES) of the skull base in reducing iatrogenic cranial nerve (CN) deficits. Design We retrospectively identified 200 patients out of 990 who had at least one EOCN monitored during EES. We further separated patients into groups according to the specific CN monitored. In each CN group, we classified patients who had significant (SG) f-EMG activity as Group I and those who did not as Group II. Results A total of 696 EOCNs were monitored. The number of muscles supplied by EOCNs that had SG f-EMG activity was 88, including CN III = 46, CN IV = 21, and CN VI = 21. There were two deficits involving CN VI in patients who had SG f-EMG activity during surgery. There were 14 deficits observed, including CN III = 3, CN IV = 2, and CN VI = 9 in patients who did not have SG f-EMG activity during surgery. Conclusions f-EMG monitoring of EOCN during EES can be useful in identifying the location of the nerve. It seems to have limited value in predicting postoperative neurological deficits. Future studies to evaluate the EMG of EOCN during EES need to be done with both f-EMG and triggered EMG.
Ultrasonic Visualization of a Dilated Cervix During Pregnancy (1979)

Although a closed cervix is a normal finding during pregnancy, dilated endocervical canals were visualized ultrasonically prior to term in three clinical situations: premature labor, inevitable abortion, and incompetent cervix. Implications for patient management are also discussed.
ChemInform Abstract: A NOVEL SYNTHESIS OF α‐METHYLENE‐Γ‐BUTYROLACTONES FROM 1‐(N,N‐DIMETHYLAMINOMETHYL)CYCLOPROPANECARBOXYLATE ESTERS (1979)

Abstract 1 ,l‐Dibrom‐cyclopropane (I) werden über die mit Bu‐Li erhaltenen Li‐Derivate mit Dimethyl‐methylenammoniumiodid zu den Dimethylaminomethyl‐Verbindungen (II) umgesetzt und diese dann mit Butylithium und Kohlensäureester in die Ester (III) umgewandelt.
Structural study of mefloquinium salts with three isomeric n-nitrobenzoates (n = 2, 3, and 4) (2010)

Abstract The crystal and molecular structures of three racemic erythro- ( R *, S *)-(±)- α -2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol n -nitrobenzoates, n = 2, 3, and 4, are described. The cations uniformly adopt an L-shaped geometry with protonation leading to a piperidin-1-ium ring in each case. A non-planar arrangement is found for the anion in ( 1 ; n = 2), owing to steric congestion, but almost planar arrangements are found in each of the anions in ( 2 ; n = 3) and ( 3 ; n = 4). Supramolecular chains are found in each of the crystal structures but these are sustained by different hydrogen bonding synthons. More efficient crystal packing in ( 3 ; n = 4) is correlated with a single synthon as opposed to two distinct synthons in each of ( 1 ; n = 2) and ( 2 ; n = 3). Crystal data for ( 1 ; n = 2): monoclinic, P 2 1 / n, a = 13.2144(6), b = 8.1028(2), c = 22.9724(9) Å, β = 105.919(1)°, V = 2365.41(15) Å 3 , Z = 4, R = 0.053. Crystal data for ( 2 ; n = 3): monoclinic, P 2 1 / n, a = 6.8389(2), b = 12.8432(4), c = 26.7910(9) Å, β = 90.868(2)°, V = 2352.87(13) Å 3 , Z = 4, R = 0.044. Crystal data for ( 3 ; n = 4): monoclinic, P 2 1 / n, a = 16.9854(8), b = 6.5069(2), c = 20.2083(9) Å, β = 92.116(2)°, V = 2231.94(16) Å 3 , Z = 4, R = 0.065.
Municipal Solid Waste (MSW) Compost Maturity Influence on Weed Seed Germination (1996)

The influence of compost (derived from MSW and biosolids) maturity on seed germination of several weed species was evaluated. A bioassay was developed by extracting 20 g of compost of different maturities with various volumes of water, then measuring germination percentage of ivyleaf morningglory ( Ipomoea hederacea ) seeds placed on extract-saturated filter paper in a petri dish. A 20 g (dry weight) compost: 50 mL of water generated an extract that produced the widest percentage seed germination variation in response to composts of different maturity. Ivyleaf morningglory, barnyardgrass ( Echinochloa crus-galli L.), purslane ( Potulaca oleracea L.), and corn ( Zea mays L) were selected as plant indicators to determine the compost maturity stage with maximum germination inhibition. Compost 8-week-old decreased percent germination, root growth, and germination index (combines germination rate and root growth), and increased mean days to germination (MDG) of each plant indicator. Immature 8 week-old compost extract effect on MDG and germination percent of 15 weed species was evaluated. Extract from 8-week-old compost inhibited germination in most weed species, except yellow nutsedge ( Cyperus esculentus ). Compost extracts derided from immature (3-day, 4-, and 8-week-old) compost resulted in delayed and reduced germination percent of important economic weed species.
Acte sans Comité de Lecture : "Molecular sieve silica-based membranes for He purification" (2006)

Proc. 9th International Conference on Inorganic Membranes (ICIM9), Lillehammer (Norway), June 25-29, 2006
Lamb wave tomography (2002)

Tomographic imaging of the condition of tin materials has been performed using Lamb waves. Lamb waves were generated in thin sheets of aluminum submerged in water using an immersion transducer set at the critical angle. An identical transducer at a fixed separation detected energy radiated back into the water by the propagating Lamb wave. Waveforms from the receiving transducer were captured and stored for a set scan pattern with an automated data collection system under the control of a microcomputer. Both the amplitude variation and propagation delay were used to obtain tomographic images of attenuation and velocity, based on a filtered back-projection technique. Representative reconstructions of both slowness and attenuation variations are shown, illustrating the technique's success in imaging defects in thin materials.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
PROGRESS ON THE DEVELOPMENT OF SHAPE-MEMORY-ALLOY METACOMPOSITES (2021)

Shape memory alloys (SMA) have long been explored as a semi-passive approach to mechanical energy dissipation particularly, but not exclusively, for application to vibration control. More recently, the integration of SMAs in composite materials has opened the opportunity to synthesize tunable composite structures exhibiting significantly enhanced energy dissipation characteristics and a certain degree of adaptability to different operating conditions. Despite the significant progress in the development and manufacturing of SMAs over the past several decades, the cost of common Ni-based alloys has remained an important factor hindering their widespread engineering application. The long-term goal of this research effort is to model, design, and fabricate shape-memory-alloy (SMA) meta-composites employing lower volume fractions of a more affordable Cu-based alloy, while still enabling enhanced and tunable dynamic properties. This paper summarizes recent progress in the development of the meta-composite platform and focuses on aspects involving both numerical modeling and fabrication of SMA materials. On the modeling side, particular emphasis is given to assess the ability to tune the dynamic performance of continuous SMA structures by exploiting the different phases and transformations of the alloy. On the other side, the material development effort focuses on the identification of the optimal chemical composition, mechanical and heat treatment processes. A combination of numerical and experimental results is presented to illustrate capabilities and opportunities presented by this material platform.
Feedforward Control of the Temperature Field in an Experimental Annealing Furnace (2017)

Two feedforward control strategies for an experimental annealing furnace equipped with electrically powered infrared (IR) lamps are developed and compared. For the first controller, the optimal time evolution of the electric power supplied to IR-lamps is computed from a dynamic optimization problem. This ensures optimal temperature trajectories and temperature uniformity in the specimen fillet. The second controller is based on an amplified adjustment of the steady-state power distribution obtained from static optimization at an operating point. Here, the temperature uniformity during transients is traded-off against the computing time while still ensuring the best temperature uniformity at the final temperature level. For both strategies, a tailored control-oriented reduced-order model of the 2D spatial-temporal temperature evolution is used. The evaluation of the feedforward controllers is carried out with an experimentally validated simulation model. The temperature non-uniformity during transients is less than 0.9 % and reduces to 0.3 % of the setpoint value at the steady state.
Enantioselective Phase‐Transfer Catalytic α‐Benzylation and α‐Allylation of α‐tert‐Butoxycarbonyllactones (2013)

Abstract A new enantioselective α‐benzylation and α‐allylation of α‐ tert ‐butoxycarbonyllactones was devloped. α‐Benzylation and α‐allylation of α‐ tert ‐butoxycarbonylbutyrolactone and α‐ tert ‐butoxycarbonylvalerolactone under phase‐transfer catalytic conditions (50% cesium hydroxide, toluene, −60 °C) in the presence of ( S , S )‐3,4,5‐trifluorophenyl‐NAS bromide (1 mol%) afforded the corresponding α‐substituted α‐ tert ‐butoxycarbonyllactones in very high chemical yields (up to 99%) and optical yields (up to 99% ee ). The synthetic potential of this method has been successfully demonstrated by the asymmetric synthesis of unnatural α‐quaternary homoserines, 3‐alkyl‐3‐carboxypyrrolidine and 3‐alkyl‐3‐carboxypiperidine.
Therapy and management of frontal lobe dementia patients (2001)

Patients with frontal lobe dementia (FLD) include those who suffer from Pick's disease, corticobasal degeneration, FLD without specific histopathologic features, as well as the infrequent families with frontotemporal dementia and parkinsonism associated with chromosome 17. Currently there have been no systematic efforts to manage and to treat patients with FLD. Drawing on the accumulated experience of clinicians and the known therapeutic approaches for patients with other neurodegenerative disorders such as AD and PD, the author discusses possible neurotransmitter replacement and biologic therapeutic approaches for patients with FLD.
Dimension reduction in principal component analysis for trees (2021)

The statistical analysis of tree structured data is a new topic in statistics with wide application areas. Some Principal Component Analysis (PCA) ideas were previously developed for binary tree spaces. In this study, we extend these ideas to the more general space of rooted and labeled trees. We re-de ne concepts such as tree-line and forward principal component tree-line for this more general space, and generalize the optimal algorithm that fi nds them. We then develop an analog of classical dimension reduction technique in PCA for the tree space. To do this, we de ne the components that carry the least amount of variation of a tree data set, called backward principal components. We present an optimal algorithm to find them. Furthermore, we investigate the relationship of these the forward principal components, and prove a path-independency property between the forward and backward techniques. We apply our methods to a data set of brain artery data set of 98 subjects. Using our techniques, we investigate how aging affects the brain artery structure of males and females. We also analyze a data set of organization structure of a large US company and explore the structural differences across different types of departments within the company.
Membrane Transporter Genes in Cephabacin Biosynthetic Gene Cluster of Lysobacter lactamgenus (2001)

In order to clone the peptide synthetase gene from Lysobacter lactamgenus IFO 14,288, the gene fragments were amplified using primers for the adenylation domain and the thionylation domain of the peptide synthetase genes in other organisms by polymerase chain reaction (PCR). The resulting 0.5-kb fragment was cloned in a pGEM-T vector, and the nucleotide sequences were determined. Six different PCR products were obtained; three were identified to be a part of L-α-aminoadipyl-L-cysteinyl-D-valine (ACV) synthetase and three to be other peptide synthetases. Using each of the two different classes of PCR products as mixed probes, a cosmid library of L. lactamgenus chromosomal DNA constructed in a pHC79 vector was screened by an in situ hybridization procedure, and one positive clone was selected which was bound by peptide synthetase gene fragments as well as ACV synthetase gene fragments. The partial sequence analysis from the obtained pPTS-5 cosmid showed the presence of more than two open reading frames. These were for two putative membrane transporters, which were homologous with several integral membrane proteins including the ABC transporter ATP-binding protein of E. coli (YbjZ) and the metal ion uptake protein of Bacillus subtilis (YvrN). A 45% homology was also found between the two transporter proteins at the carboxy terminus. Through a hydropathy analysis and transmembrane analysis, 4-5 transmembrane domains were found in these two proteins. When the genes were expressed in Escherichia coli, the gene products inhibited the host cell growth, probably due to the disturbance of the membrane transport system.
A first-in-human phase I study of the oral Notch inhibitor LY900009 in patients with advanced cancer. (2012)

3008 Background: Notch signaling plays a critical role during stem cell self-renewal and is deregulated in multiple human cancers. The Notch pathway may be activated inappropriately by receptor mutation and overexpression as well as aberrant signals from the tumor microenvironment. LY900009 is a selective small-molecule inhibitor of gamma secretase, the enzyme that cleaves and thereby activates Notch receptors. Methods: Dose escalation was performed in cohorts of 3 patients (pts) using a modified continual reassessment method. LY900009 was taken orally thrice weekly (every MWF) during a 28-day cycle. Safety, pharmacokinetic, pharmacodynamic, and clinical endpoints were evaluated. Results: 22 patients received LY900009 across 6 dose levels: 2mg (3pts), 4mg (4pts), 8mg (3pts), 15mg (3pts), 30mg (6pts), and 60mg (3pts). The most common treatment emergent adverse events possibly related to LY900009 across all grades included diarrhea (27%), vomiting (23%), nausea (18%), fatigue (23%), anorexia (23%), hypophosphatemia (14%), and rash (18%). Dose-limiting toxicities of fatigue/N/V (G3) and diarrhea (G3) were seen in 2 patients, respectively, treated at 60mg. The maximum tolerated dose (MTD) was tentatively identified at 30mg. After a single dose, mean Cmax increased from 4 to 158 ng/ml and mean AUC 0-t(last) increased from 14 to 1160 ng-hr/ml. Both Cmax and AUC 0-t(last) increased in a dose-dependent manner. Elimination half-life of LY900009 was approximately 2-3 hrs. LY900009 inhibited plasma levels of amyloid-β peptide (a downstream product of gamma secretase) in a dose-dependent manner with 80-90% inhibition observed in the 30 and 60mg cohorts. In the 15mg cohort, one patient had colonic biopsy that showed markedly increased glandular mucin consistent with pharmacologic inhibition of the Notch pathway. Two patients (10%) with leiomyosarcoma and ovarian cancer received 4 cycles of therapy. Conclusions: LY900009 demonstrates acceptable safety and pharmacokinetics in patients with advanced cancer. Pharmacodynamic endpoints show pathway inhibition at tolerable doses. One more cohort at 45mg is ongoing to refine the MTD and will be followed by an expansion cohort for patients with ovarian cancer.
Proceedings of the 3rd international workshop on Visualization for computer security (2006)

It is our great pleasure to welcome you to the 3rd International Workshop on Visualization for Computer Security -- VizSEC'06 held November 3rd, 2006 at George Mason University in conjunction the Thirteenth ACM Conference on Computer and Communications Security (CCS). This year's workshop continues its tradition of being the premier forum for presentation of research results and experience reports on visualization for cybersecurity. VizSEC provides researchers and practitioners the unique opportunity of a focused workshop environment to share their ideas with others from around the world interested in applying visualization techniques to the application domain of Internet security.The VizSEC'06 call-for-papers attracted 44 submissions from Asia, Australia, Canada, Europe, and the United States. The program committee accepted 19 papers that cover a wide variety of topics. In addition to traditional VizSEC'06 strengths in system administration tools, traffic visualization, intrusion detection, and routing -- this year we have industry participation (3 papers and 8 members of the program committee), and papers on new topics such as wireless, encryption, and DNS. While the accepted papers are USA-centric, there are accepted papers from Australia, Canada, Israel, Japan, and Switzerland. Future VizSEC'06 workshops will seek to increase international participation. This year we also introduced two new paper categories: (1) update papers on tools presented at previous VizSEC'06 workshops and (2) position papers. It is our hope these two new paper categories will provide another opportunity for communicating interesting work in future VizSEC'06workshops.
ChemInform Abstract: SYNTHESIS OF PERI‐FUSED INDOLIZINES AND AZAINDOLIZINES BY INTRAMOLECULAR 1,3‐DIPOLAR CYCLOADDITION OF 3‐(PHENYLPROPYNOYLOXYALKYL)PYRIDINE N‐YLIDES (1985)

Abstract Erhitzen des Salzes (IIIa) in MeOH‐KZCO, führt zu den Azaindolizinen (IV) und (V).