gebhart/patrepeval huggingface dataset:
Acylation of SC4 dodecapeptide increases bactericidal potency against Gram-positive bacteria, including drug-resistant strains (2004)

We have conjugated dodecyl and octadecyl fatty acids to the N-terminus of SC4, a potently bactericidal, helix-forming peptide 12-mer (KLFKRHLKWKII), and examined the bactericidal activities of the resultant SC4 'peptide-amphiphile' molecules. SC4 peptide-amphiphiles showed up to a 30-fold increase in bactericidal activity against Gram-positive strains (Staphylococcus aureus, Streptococcus pyogenes and Bacillus anthracis), including S. aureus strains resistant to conventional antibiotics, but little or no increase in bactericidal activity against Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). Fatty acid conjugation improved endotoxin (lipopolysaccharide) neutralization by 3- to 6-fold. Although acylation somewhat increased lysis of human erythrocytes, it did not increase lysis of endothelial cells, and the haemolytic effects occurred at concentrations 10- to 100-fold higher than those required for bacterial cell lysis. For insight into the mechanism of action of SC4 peptide-amphiphiles, CD, NMR and fluorescence spectroscopy studies were performed in micelle and liposome models of eukaryotic and bacterial cell membranes. CD indicated that SC4 peptide-amphiphiles had the strongest helical tendencies in liposomes mimicking bacterial membranes, and strong membrane integration of the SC4 peptide-amphiphiles was observed using tryptophan fluorescence spectroscopy under these conditions; results that correlated with the increased bactericidal activities of SC4 peptide-amphiphiles. NMR structural analysis in micelles demonstrated that the two-thirds of the peptide closest to the fatty acid tail exhibited a helical conformation, with the positively-charged side of the amphipathic helix interacting more with the model membrane surface. These results indicate that conjugation of a fatty acid chain to the SC4 peptide enhances membrane interactions, stabilizes helical structure in the membrane-bound state and increases bactericidal potency.
VideoBook: an experiment in characterization of video (2002)

We present a framework for content based query and retrieval of information from large video databases. This framework enables content based retrieval of video sequences by characterizing the sequences using motion, texture and colorimetry cues. This characterization is biologically inspired and results in a compact parameter space where every segment of video is represented by an 8 dimensional vector. Searching and retrieval is done in real-time with high accuracy in this parameter space. The present version of the VideoBook has 165 video sequences, each 15 seconds long at 30 frames a second representing storage of 65 Giga bytes. The VideoBook is able to search and retrieve video sequences with 92% accuracy in real-time. Experiments thus demonstrate that the characterization is capable of extracting higher level structure from raw pixel values.
Does Modularity Affect Clinical Success? (2001)

A comparison of the clinical and radiographic results of patients with metal-backed monoblock Insall-Burstein I and modular Insall-Burstein II Posterior Stabilized Knee Prostheses was done. The minimum followup was 10 years. The clinical results were comparable with a similar average Hospital for Special Surgery knee score of 85 and 84 points, respectively. Likewise, the Knee Society Knee and Functional Scores showed no statistical difference. Radiographically, the incidence of minor radiolucent lines was 11% for the Insall-Burstein I prostheses and 29% for the Insall-Burstein II prostheses, but their presence was of no clinical significance. There was no clinical or radiographic evidence of tibial component loosening with either prosthetic design and there were no revisions for polyethylene wear or osteolysis in either cohort of patients.
Supplementary Tables and Figures from Deep Learning to Estimate RECIST in Patients with NSCLC Treated with PD-1 Blockade (2023)

&lt;p&gt;Supplementary Tables and Figures&lt;/p&gt;
Metrics for the National SCADA Test Bed Program (2008)

The U.S. Department of Energy Office of Electricity Delivery and Energy Reliability (DOE-OE) National SCADA Test Bed (NSTB) Program is providing valuable inputs into the electric industry by performing topical research and development (R&D) to secure next generation and legacy control systems. In addition, the program conducts vulnerability and risk analysis, develops tools, and performs industry liaison, outreach and awareness activities. These activities will enhance the secure and reliable delivery of energy for the United States. This report will describe metrics that could be utilized to provide feedback to help enhance the effectiveness of the NSTB Program.
Comparison of the behavior of normal factor IX and the factor IX BM variant hilo in the prothrombin time test using tissue factors from bovine, human, and rabbit sources (1993)

A subset of hemophilia B patients have a prolonged bovine-brain prothrombin time. These CRM+ patients are classified as having hemophilia Bm. The prolongation of the prothrombin time has been reported only with bovine brain (referred to as ox brain in some literature) as the source of thromboplastin; prothrombin times determined with thromboplastin from rabbit brain or human brain are not reported to be prolonged. Factor IX from a hemophilia Bm patient (factor IX Hilo) was isolated. The activity of factor IX Hilo was compared to that of normal factor IX in prothrombin time assays when the thromboplastin source was of bovine, rabbit, or human origin. Factor IX, either normal or Hilo, prolonged a prothrombin time regardless of the tissue factor source. However, unless thromboplastin was from a bovine source, this prolongation required high concentrations of factor IX. Further, factor IX normal was as effective as factor IX Hilo in prolonging the prothrombin time when rabbit or human thromboplastin was used. With bovine thromboplastin, factor IX Hilo was significantly better than factor IX normal at prolonging the prothrombin time. The amount of prolongation was dependent on the amount of factor IX Hilo added. In addition, the prolongation was dependent on the concentration of factor X present in the sample. The prothrombin time changed as much as 20 seconds when the factor X concentration was varied from 50% to 150% to normal (fixed concentration of factor IX Hilo). These results demonstrate the difficulty of classifying the severity of a hemophilia Bm patient based on the bovine brain prothrombin time unless both the factor IX and factor X concentrations are known.
Phenolic Compounds from Caesalpinia sappan Heartwood and Their Anti-inflammatory Activity (2012)

Four new phenolic compounds, caesalpiniaphenols A-D (1-4), together with eight known compounds were isolated from Caesalpinia sappan heartwood. The chemical structures were established mainly by NMR, MS, ECD, and Mosher's method. Compounds 4, 5, and 7 showed weak inhibitory activity against the LPS-induced NO production in macrophage RAW264.7 cells with IC(50) values of 12.2, 3.5, and 5.7 μM, respectively.
From bench to bedside and back’: Rethinking MedTec innovation and technology transfer through a dedicated Makerlab (2021)

This research protocol paper presents key lessons learned at Innolab IGT, a medical, technology, and innovation laboratory that has short distances between operating rooms and labs, responsive communication, and the ability to identify clinical needs directly.
Type IX Collagen Neo-Deposition in Degenerative Discs of Surgical Patients Whether Genotyped Plus or Minus for COL9 Risk Alleles (2011)

During growth and maturation of the disc, collagen IX is presumably removed completely during matrix remodeling so that the protein is absent from normal adult annulus and nucleus but can reappear at sites of degeneration presumably as part of a repair response to mechanical injury.
Structural shape and topology optimization of cast parts using level set method (2017)

Summary This paper presents a level set‐based shape and topology optimization method for conceptual design of cast parts. In order to be successfully manufactured by the casting process, the geometry of cast parts should satisfy certain moldability conditions, which poses additional constraints in the shape and topology optimization of cast parts. Instead of using the originally point‐wise constraint statement, we propose a casting constraint in the form of domain integration over a narrowband near the material boundaries. This constraint is expressed in terms of the gradient of the level set function defining the structural shape and topology. Its explicit and analytical form facilitates the sensitivity analysis and numerical implementation. As compared with the standard implementation of the level set method based on the steepest descent algorithm, the proposed method uses velocity field design variables and combines the level set method with the gradient‐based mathematical programming algorithm on the basis of the derived sensitivity scheme of the objective function and the constraints. This approach is able to simultaneously account for the casting constraint and the conventional material volume constraint in a convenient way. In this method, the optimization process can be started from an arbitrary initial design, without the need for an initial design satisfying the cast constraint. Numerical examples in both 2D and 3D design domain are given to demonstrate the validity and effectiveness of the proposed method. Copyright © 2017 John Wiley &amp; Sons, Ltd.
A NEW SPECIES OF ON COPERA (LEPIDOPTERA: HEPIALIDAE) FROM NEW SOUTH WALES, WITH TAXONOMIC NOTES ON THE GENUS (1966)

Abstract Oncopera tindalei sp. n. (Hepialidae) is described from Guyra, New South Wales, where the larvae damage pastures. Characters of the adult used to distinguish it and other species of Oncopera are discussed and figured, including the genitalia of both sexes.
Figure S6 from Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity (2023)

&lt;p&gt;mRNA expression of activation markers and cytokines in CD8 T cells.&lt;/p&gt;
Thewtoin Bali: whatmc9 means for the Doha Development Agenda and why it matters (2014)

The conclusion of the World Trade Organization’s (wto) ninth ministerial meeting – held in Bali 3–7 December 2013 – is at one and the same time momentous, marginal and business-as-usual. It is momentous because it marks the first multilateral agreement reached in the wto since the organisation began operations on 1 January 1995; it is marginal because the deal reached will have only a limited impact on the global trading system; and it is business as usual because the Bali package will be of disproportionally greater value to the industrial states than to their developing and least developed counterparts. We examine what happened in Bali, covering the principal issues at stake and the content of the outcome, what this means for the wto and for the Doha Development Agenda (dda), and why it all matters. We argue that, while the Bali ministerial is significant and the agreements reached important, the conclusion of the meeting and the package agreed represent only a limited movement forward in addressing the fundamental problems and inequities of the wto system.
Repeatability and reproducibility of desorption electrospray ionization-mass spectrometry (DESI-MS) for the imaging analysis of human cancer tissue: a gateway for clinical applications (2014)

The repeatability and reproducibility of DESI-MS for the measurement of lipid ion intensities in human cancer tissue is 22 ± 7% and 18 ± 8%, respectively.
Hybrid Integrated Optical Phase-Lock Loops for Photonic Terahertz Sources (2010)

We present the first hybrid-integrated optical phase-lock loop (OPLL) for use in high spectral purity photonic terahertz sources. We have achieved the necessary short loop delay to lock a 1-MHz linewidth slave laser by hybrid integration of the slave laser and photodetector on a silicon motherboard with silica optical waveguides and combining this with a custom-designed low-delay electronic loop filter circuit. The laser and photodetectors are InP-based and are flip chip bonded to silicon daughter boards, which are in turn attached to the motherboard. Delay between the slave laser and photodiode was approximately 50 ps. The heterodyne between slave and master sources has a linewidth of less than 1 kHz and achieved phase noise less than -80 dBc/Hz at an offset of 10 kHz. The slave laser can be offset from the master source by 2-7 GHz, using a microwave oscillator. This integrated OPLL circuit was used with an optical comb source and an injection-locked laser comb filter to generate high spectral purity signals at frequencies up to 300 GHz with linewidths <;1 kHz and powers of about -20 dBm, while the two integrated lasers could deliver a tunable heterodyne signal at frequencies up to 1.8 THz.
Genetic variation and intergenerationalFMR1 CGG-repeat stability in 100 unrelated three-generation families from the normal population (1999)

In order to identify genetic factors governing expansion of the CGG repeat in the FMR1 gene and to determine what predisposes or causes a normal stable allele to change to an unstable premutation allele, it is essential to study and understand the basis of normal variation. The aim of this study was to investigate genetic variation and intergenerational stability of the FMR1 CGG-repeat region in 100 unrelated three-generation families from the general population (651 meioses). The number of CGG-repeats in the FMR1 gene was determined in all 750 individuals from the 100 families (a total of 1,132 X-chromosomes), and the allele frequencies and variability were analyzed. Thirty-six different alleles (12-60 repeats) were seen with 30 (45.8%) as the most common allele; overall female heterozygosity was 73%. Most (>96%) of the normal array lengths were less than 40 repeats. Fifteen families with at least one allele equal to or greater than 40 repeats (40-60) were identified; in one of these families there was an increase of one triplet repeat during transmission from a mother to son. These findings, together with future molecular analyses, may provide data to test proposed models that attempt to explain the mutational process and the population dynamics of the triplet repeat region of the FMR1 gene, including the transition from normal to unstable alleles, or to test other putative cis-acting sequences that may be involved with instability in the FMR1 gene.
An Expedient Synthesis and Screening for Antiacetylcholinesterase Activity of Piperidine Embedded Novel Pentacyclic Cage Compounds (2014)

The aim of this study was to synthesize and evaluate diazapentacyclic analogs for their acetylcholinesterase (AChE) inhibitory activity. The pentacyclic analogs were synthesized by one-pot three-component domino reactions in a microwave synthesizer. Most of the compounds exhibited moderate to good AChE inhibitory activity, compound 5i showed potent inhibitory activity with IC50 1.12 ± 0.01 µM and this may provide a new lead for developing potential inhibitors for Alzheimer's disease.
IgA anti-endomysial antibodies in dermatitis herpetiformis: correlation with jejunal morphology, gluten-free diet and anti-gliadin antibodies (1987)

Circulating IgA-class anti-endomysium antibodies (EmA) can be detected by indirect immunofluorescence on monkey oesophagus sections. We found EmA in 22 (76%) of 29 patients with dermatitis herpetiformis (DH) on a normal, gluten-containing diet. The highest frequency (100%) of EmA was observed in patients with sub-total villous atrophy. IgA-class antigliadin antibodies (AGA) were found using an ELISA method in 59% of 29 DH patients and in 86% of those with sub-total villous atrophy. There was a significant correlation between EmA titres and AGA levels in individual patients. Gluten-free diet (GFD) treatment caused a rapid decrease in EmA titres; only three of the 12 patients still showed raised EmA after 6-12 months on a GFD and two of these three had failed to adhere to a strict diet. In contrast, no decrease in EmA titres occurred in four patients maintained on a normal diet, and two of the three patients with initially negative EmA developed positive titres when continuing on a normal diet. These results show that both IgA-class EmA and AGA are good indicators of jejunal damage in DH. The rapid fall of EmA titres after gluten withdrawal indicates that this test is also useful for monitoring a patient's adherence to a GFD.
A distributed localization hierarchy for an AUV swarm (2014)

Localization of teams of autonomous underwater vehicles (AUVs) still remains as a challenge in large-scale ocean currents. In this study, moving references, drifting under the influence of the ocean background flow, were employed in order to improve the cooperative localization (CL) performance of an AUV swarm in harsh ocean flows. More capable AUVs (dubbed as mother AUVs) with less localization error were utilized as moving references for improving localization error of less capable AUVs (called daughter AUVs). Limitations of a previously proposed modified extended Kalman filter (MEKF) were identified. A particle filter (PF) based algorithm was proposed to address those issues. The performance of the PF algorithm was compared with the MEKF algorithm in several simulated examples including CL in an N-vortex background flow field. Both algorithms can effectively avoid the diverging behavior of localization error in pure CL. The PF algorithm is more robust in choosing the better localized AUV. With a large number of particles, the PF algorithm outperforms the MEKF algorithm at the expense of computational efforts.
Repetitive Pitch Control for Vertical Axis Wind Turbine (2018)

Increasing demands in decentralized power plants have focused attention on Vertical Axis Wind Turbines (VAWTs). However, accessing high range of power from VAWTs is an impediment due to increased loads on the turbine blades. Here, we derive an optimal pitching action that reduces the periodic disturbance on turbine blades of VAWTs without affecting their power production. A control technique called Subspace Predictive Repetitive Control (SPRC) alongwith a LQ Tracker is used for recursive identification to estimate the parameters of VAWT model and further provide an optimal control law accordingly. Basis functions have been used to reduce the dimensionality of the control problem. Simulation results show a great potential of the data-driven SPRC approach coupled with LQ Tracker in reducing the turbine loads on VAWTs.
Inductance Estimation of Electrically Excited Synchronous Motor via Polynomial Approximations by Least Square Method (2014)

Electrically excited synchronous motors are designed to have high power density for electric vehicle applications. During a high-torque operation, severe nonlinearities associated with a saturation are observed: change of inductances, emergence of cross-coupling effects, variation of back EMF coefficient, etc. A flux linkage map over the current plane is obtained via finite-element analysis (FEA), and it is fitted by a third-order polynomial with the use of the least square method. Then, by grouping terms of the polynomial, the inductances are expressed as functions of currents. The validity of inductance fitting is shown by comparing with FEA and experimental results. This enables us to predict inductances online instead of using premade lookup table. The torque equation is expanded by incorporating the cross-coupling inductances, for which an extended maximum torque per ampere (MTPA) is developed by using Ferrari's method to a quartic equation. The extended MTPA locus is compared with the experimental optimal results.
Microwave moisture meter for granular and particulate materials (2010)

A low-cost microwave moisture meter operating at a single frequency for instantaneous and nondestructive determination of moisture content of granular and particulate materials was developed, calibrated and tested with different kinds of grain and seed. The meter operates at a single microwave frequency of 5.8 GHz and uses the principle of free-space transmission measurement for the determination of attenuation, phase shift, and dielectric properties of a layer of material. Moisture content is determined independent of bulk density from the dielectric properties with a permittivity-based algorithm.
Attribute-Centered Loss for Soft-Biometrics Guided Face Sketch-Photo Recognition (2018)

Face sketches are able to capture the spatial topology of a face while lacking some facial attributes such as race, skin, or hair color. Existing sketch-photo recognition approaches have mostly ignored the importance of facial attributes. In this paper, we propose a new loss function, called attribute-centered loss, to train a Deep Coupled Convolutional Neural Network (DCCNN) for facial attribute guided sketch to photo matching. Specifically, an attribute-centered loss is proposed which learns several distinct centers, in a shared embedding space, for photos and sketches with different combinations of attributes. The DCCNN simultaneously is trained to map photos and pairs of testified attributes and corresponding forensic sketches around their associated centers, while preserving the spatial topology information. Importantly, the centers learn to keep a relative distance from each other, related to their number of contradictory attributes. Extensive experiments are performed on composite (E-PRIP) and semi-forensic (IIIT-D Semi-forensic) databases. The proposed method significantly outperforms the state-of-the-art.
DEGRADATION AND IMPACT OF PHTHALATE PLASTICIZERS ON SOIL MICROBIAL COMMUNITIES (2000)

To assess the impact of phthalateson soil microorganismsand to supplement the environmental risk assessment for these xenobiotics, soil was treated with diethyl phthalate (DEP) or di (2-ethyl hexyl) phthalate (DEHP) at 0.1 to 100 mg/g. Bioavailability and membrane disruption were proposed as the characteristics responsible for the observed fate and toxicity of both compounds. Diethyl phthalate was biodegraded rapidly in soil with a half-life (t50 deg) of 0.75 d at 20°C, and was not expected to persist in the environment. The DEHP, although biodegradable in aqueous solution (t50deg < 15 d at 20°C), was recalcitrant in soil, because of poor bioavailability (only 10% degraded by 70 d at 20°C) and was predicted to account for the majority of phthalate contamination in the environment. Addition of DEP or DEHP to soil at a concentration similar to that detected in nonindustrial environments (0.1 mg/g) had no impact on the structural diversity (bacterial numbers, fatty acid methyl ester analysis) or functional diversity (BIOLOG) of the microbial community. At concentrations representative of a phthalate spill, DEP (>1 mg/g) reduced numbers of both total culturable bacteria (by 47%) and pseudomonads (by 62%) within 1 d. This was due to disruption of membrane fluidity by the lipophilic phthalate, a mechanism not previously attributed to phthalates. However, DEHP had no effect on the microbial community or membrane fluidity, even at 100 mg/g, and was predicted to have no impact on microbial communities in the environment.
ChemInform Abstract: Aromatic Enynes as Substrates for the Intramolecular Pauson—Khand Reaction. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.