gebhart/patrepeval huggingface dataset:
Chemical Castration of Melanoma Patients Does Not Increase the Frequency of Tumor-specific CD4 and CD8 T Cells After Peptide Vaccination (2013)

Peptide vaccination against tumor-associated antigens remains one of the most common methods of immunization in cancer vaccine clinical trials. Although peptide vaccination has been reported to increase circulating antigen-specific T-cells, they have had limited clinical efficacy and there is a necessity to increase their capacity to generate strong antitumor responses. We sought to improve the clinical efficacy of peptide-based vaccines in cancer immunotherapy of metastatic melanoma using a LHRH agonist (leuprolide) as adjuvant. Seventy HLA-A*0201 stage IIb-IV melanoma patients were vaccinated with class I HLA-A*0201-restricted gp100209-2M peptide and stratified for HLA-DP4 restriction. HLA-DP4 patients were also vaccinated with class II HLA-DP4-restricted MAGE-3243-258 peptide. Patients from both groups were randomized to receive 2 doses of leuprolide or not. Here we report the increase in PBMC TREC levels at week 24 after peptide vaccination, which was independent of the leuprolide treatment. This change was mirrored by a small increase in the TREC-enriched CD8CD45RAROCD27CD103, but not the TREC-enriched CD4CD45RAROCD31 T-cell population. Serum concentration of 2 important factors for thymopoiesis was measured: insulin growth factor 1 (IGF-1) levels were not changed, whereas a moderate increase in IL-7 levels was noted in the sera of all patients 6 weeks after vaccination. Increased expression of CD127 (IL-7 receptor-α) at week 24, compared with baseline, was only seen in the CD8CD45RAROCD27CD103 T-cell population. Our results suggest that leuprolide has no effect on thymic output when used as peptide vaccine adjuvant, but IFA-based peptide vaccination may unexpectedly affect the thymus by increasing thymic output of new T cells.
High performance solid state storage under Linux (2010)

Solid state drives (SSDs) allow single-drive performance that is far greater than disks can produce. Their low latency and potential for parallel operations mean that they are able to read and write data at speeds that strain operating system I/O interfaces. Additionally, their performance characteristics expose gaps in existing benchmarking methodologies. We discuss the impact on Linux system design of a prototype PCI Express SSD that operates at least an order of magnitude faster than most drives available today. We develop benchmarking strategies and focus on several areas where current Linux systems need improvement, and suggest methods of taking full advantage of such high-performance solid state storage. We demonstrate that an SSD can perform with high throughput, high operation rates, and low latency under the most difficult conditions. This suggests that high-performance SSDs can dramatically improve parallel I/O performance for future high performance computing (HPC) systems.
Epidural steroid injection resulting in epidural hematoma in a patient despite strict adherence to anticoagulation guidelines (2009)

Epidural steroid injections are relatively safe procedures, although the risk of hemorrhagic complications in patients undergoing long-term anticoagulation therapy is higher. The American Society for Regional Anesthesia and Pain Medicine has specific guidelines for treatment of these patients when they undergo neuraxial anesthetic procedures. In this paper, the authors present a case in which the current American Society for Regional Anesthesia and Pain Medicine guidelines were strictly followed with respect to withholding and reintroducing warfarin and enoxaparin after an epidural steroid injection, but the patient nevertheless developed a spinal epidural hematoma requiring emergency surgical evacuation. The authors compare the case with the 8 other published cases of postinjection epidural hematomas in patients with coagulopathy, and the specific risk factors that may have contributed to the hemorrhagic complication in this patient is analyzed.
Banco de pruebas para panel fotovoltaico (2016)

Las condiciones operativas reales de un panel fotovoltaico (PV: PhotoVoltaic) en relacion a las especificadas por el fabricante, la degradacion de sus parametros con el paso del tiempo, las condiciones climaticas y la propia instalacion, implican un comportamiento distinto al inicialmente previsto y una disminucion en su maxima potencia, lo que se traduce en una merma de rendimiento. En este articulo se presenta una propuesta de ensayo que permite la conformacion de un banco de pruebas para caracterizar el panel PV mediante barridos de la curva corrientetension (I-V) en funcion de la temperatura (T) e irradiancia (G) medidas. Para ello se utiliza un modelo circuital simple que permite modelizar una celula PV ideal y, a partir del mismo modelizar, asimismo, el panel PV a ensayar incluyendo las perdidas ohmicas parametrizadas para una mejor caracterizacion de dicho sistema. Con los ensayos en diferentes condiciones de trabajo, y a partir de la utilizacion de un algoritmo de calculo, se obtienen los parametros del generador PV para la tension en circuito abierto (Voc), corriente de corto-circuito (Isc), punto de maxima potencia (MPP: Maximum Power Point) y de la medida del rendimiento a partir del factor de forma (FF: Fill Factor). La metodologia propuesta permite contrastar los datos del fabricante con los adquiridos bajo ensayo y con los obtenidos mediante simulacion del panel PV mediante modelo circuital simple, permitiendose una caracterizacion completa del panel fotovoltaico ensayado.
Engineering Aspects (2019)

The three major components of an ozonation system are preparation and treatment of the feed gas to the ozone generator, the ozone generator including power supply, and dissolution of the ozonized gas into the water under treatment. Selection of a mode or modes of ozonized gas dissolution is based on the water quality and the specific ozone application. Instrumentation and control of the ozone system is addressed using familiar equipment and control concepts. Evaluation of the power costs will likely require ozone production power testings, which are normally performed at the owner’s plant after construction is complete. The degree of conservatism in an ozone facility design is determined in large part by the quality of the treatment process information the design engineer has to work with. The types of materials used in fabrication of an ozone generator depend on the generator cooling method and the dryness of the feed gas.
Temporal progression in functional connectivity determines individual differences in working memory capacity (2017)

Working memory (WM) plays a critical role in cognitive skills such as, learning, reasoning, and language comprehension. WM capacity is widely used as a predictor of academic performance and many other cognitive skills. Yet, how the human brain coordinates this complex skill through its functional networks and also whether individual's WM limitations are due to contrasts in regional activation or cross-regional interconnections, remain controversial. We hypothesized that, individual differences in behavioral WM capacity could be explained by temporal dynamics in functional coupling, and the information flow within the connectome of the WM network. We recorded electrical brain activity as participants performed a visual WM task with varying degrees of cognitive load. Functional connectivity analyses on the EEG recordings were performed to identify prominent hubs and the temporal segmentation of inter-regional activities as WM processing unfolds over time. We found that neural communication during memory processing occurs predominately through short pulses of alpha-band (8-13 Hz) phase coupling that propagate in a temporally sequential manner with feedforward (bottom-up) and feedback (top-down) communication within a set of frontoparietal and fronto-temporal regions of brain. We also observed that the degree of phase coupling within fronto-parietal/temporal pathways strongly predicts working memory capacity. Additionally, this functional connectivity could distinguish individual with low vs. high WM capacity. These results underscore the importance of long-range neural network communication (phase synchrony) in WM skills and additionally the significance of temporal dynamics in functional connectivity and in particular phase synchrony.
Remote Welding, NDE and Repair of DOE Standardized Canisters (2016)

The U.S. Department of Energy (DOE) created the National Spent Nuclear Fuel Program (NSNFP) to manage DOE’s spent nuclear fuel (SNF). One of the NSNFP’s tasks is to prepare spent nuclear fuel for storage, transportation, and disposal at the national repository. As part of this effort, the NSNFP developed a standardized canister for interim storage and transportation of SNF. These canisters will be built and sealed to American Society of Mechanical Engineers (ASME) Section III, Division 3 requirements. Packaging SNF usually is a three-step process: canister loading, closure welding, and closure weld verification. After loading SNF into the canisters, the canisters must be seal welded and the welds verified using a combination of visual, surface eddy current, and ultrasonic inspection or examination techniques. If unacceptable defects in the weld are detected, the defective sections of weld must be removed, re-welded, and re-inspected. Due to the high contamination and/or radiation fields involved with this process, all of these functions must be performed remotely in a hot cell. The prototype apparatus to perform these functions is a floor-mounted carousel that encircles the loaded canister; three stations perform the functions of welding, inspecting, and repairing the seal welds. A welding operator monitors and controls these functions remotely via a workstation located outside the hot cell. The discussion describes the hardware and software that have been developed and the results of testing that has been done to date.
Sufficient conditions for the existence of a path-factor which are related to odd components (2017)

In this paper, we are concerned with sufficient conditions for the existence of a $\{P_{2},P_{2k+1}\}$-factor. We prove that for $k\geq 3$, there exists $\varepsilon_{k}&gt;0$ such that if a graph $G$ satisfies $\sum_{0\leq j\leq k-1}c_{2j+1}(G-X)\leq \varepsilon_{k}|X|$ for all $X\subseteq V(G)$, then $G$ has a $\{P_{2},P_{2k+1}\}$-factor, where $c_{i}(G-X)$ is the number of components $C$ of $G-X$ with $|V(C)|=i$. On the other hand, we construct infinitely many graphs $G$ having no $\{P_{2},P_{2k+1}\}$-factor such that $\sum_{0\leq j\leq k-1}c_{2j+1}(G-X)\leq \frac{32k+141}{72k-78}|X|$ for all $X\subseteq V(G)$.
Vinyl cations. 14. Preparation and solvolysis of (bromomethylene)cyclopropanes. Generation of stabilized vinyl cations (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVinyl cations. 14. Preparation and solvolysis of (bromomethylene)cyclopropanes. Generation of stabilized vinyl cationsMichael Hanack, Tilman Baessler, Wolfgang Eymann, William E. Heyd, and Richard KoppCite this: J. Am. Chem. Soc. 1974, 96, 21, 6686–6691Publication Date (Print):October 1, 1974Publication History Published online1 May 2002Published inissue 1 October 1974https://pubs.acs.org/doi/10.1021/ja00828a024https://doi.org/10.1021/ja00828a024research-articleACS PublicationsRequest reuse permissionsArticle Views241Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dublin Merchants and the Irish Repeal Movement of the 1840s. (2010)

This paper is concerned with Dublin Merchants and the Repeal movement. The Repeal movement, which demanded the legislative independence of Ireland, spilt over not only onto the whole island, but also a part of the United Kingdom and the United States. By discussing various \ntopics such as “Municipal Corporation Reform”, “Repeal Wardens” and “Repeal Reading Rooms”, I attempt to explain the role of Dublin Merchants in the movement. Especially, I emphasise the “Dublin Remonstrance” as a reform of the Repeal movement. In the “Dublin Remonstrance”, \nDublin Merchants criticised the Repeal Association. This became the original motive for the establishment of the Irish Confederation in 1847.
PARAMETRIC ANALYSIS OF PARASITIC PRESSURE DROP AND HEAT LOSSES FOR A PARABOLIC TROUGH WITH CONSIDERATIONS OF VARYING APERTURE SIZES AND RECEIVER SIZES. (2016)

Abstract not provided.
Synthesis of Sugar &#946;-Amino Acid Containing Homooligomeric Cyclic Peptides (2008)

The synthesis of new cyclic peptides built from D-mannose-derived “anomeric” β3,3-aminoacids has been carried out using a solution-phase coupling methodology. Tetramers and hexamers in which the peptide backbone includes the anomeric carbon of the sugar are obtained and show perfect symmetry by nmr clearly indicating the occurrence of rapid interchanging conformers in solution. The lowest energy conformers obtained by molecular modelling suggest a bowl shape for the peptide backbone in which intramolecular hydrogen bonds between NH and CO of the amide group but also unusual hydrogen bonds involving the sugar ring oxygen could exist. Keywords: Carbohydrate, beta-aminoacid, cyclopeptide, macrocycle, multivalency
Efficacy of belimumab combined with rituximab in severe systemic lupus erythematosus: study protocol for the phase 3, multicenter, randomized, open-label Synbiose 2 trial (2022)

ClinicalTrials.gov NCT03747159 . Registered on 20 November 2018.
How Mn/Ni Ordering Controls Electrochemical Performance in High-Voltage Spinel LiNi0.44Mn1.56O4 with Fixed Oxygen Content (2020)

The crystal structure of LiNi0.5Mn1.5O4 (LNMO) can adopt either low-symmetry ordered (Fd3̅m) or high-symmetry disordered (P4332) space group depending on the synthesis conditions. A majority of published studies agree on superior electrochemical performance of disordered LNMO, but the underlying reasons for improvement remain unclear due to the fact that different thermal history of the samples affects other material properties such as oxygen content and particle morphology. In this study, ordered and disordered samples were prepared with a new strategy that renders samples with identical properties apart from their cation ordering degree. This was achieved by heat treatment of powders under pure oxygen atmosphere at high temperature with a final annealing step at 710 °C for both samples, followed by slow or fast cooling. Electrochemical testing showed that cation disordering improves the stability of material in charged (delithiated) state and mitigates the impedance rise in LNMO∥LTO (Li4Ti5O12) and LNMO∥Li cells. Through X-ray photoelectron spectroscopy (XPS), thicker surface films were observed on the ordered material, indicating more electrolyte side reactions. The ordered samples also showed significant changes in the Ni 2p XPS spectra, while the generation of ligand (oxygen) holes was observed in the Ni–O environment for both samples using X-ray absorption spectroscopy (XAS) and resonant inelastic X-ray scattering (RIXS). Moreover, high-resolution transmission electron microscopy (HRTEM) images indicated that the ordered samples show a decrease in ordering near the particle surface after cycling and a tendency toward rock-salt-like phase transformations. These results show that the structural arrangement of Mn/Ni (alone) has an effect on the surface and “near-surface” properties of LNMO, particularly in delithiated state, which is likely connected to the bulk electronic properties of this electrode material.
Evaluation of analgesic and anti-inflammatory activities of Nectandra megapotamica (Lauraceae) in mice and rats (2004)

The bioactivity-guided phytochemical investigation of the crude hydralcoholic extract of Nectandra megapotamica was carried out using the abdominal constriction test in mice, which led to the isolation of three active compounds: alpha-asarone (1), galgravin (2) and veraguensin (3). The crude extract (EBCA, 300 mg kg(-1)) and isolated compounds 1,2, and 3, at different doses, were evaluated using the acetic acid-induced abdominal constriction test in mice, carrageenan-induced paw oedema in rats, and hot plate tests in rats. The EBCA showed a significant effect in the abdominal constriction and hot plate tests, but did not show activity in the rat paw oedema assay. All isolated compounds displayed activity in the abdominal constriction test, but only compound 1 was active in the hot plate test. Compounds 2 and 3 displayed activity in the anti-inflammatory assay. It was suggested that the analgesic effects obtained for EBCA could be due mainly to the presence of its major compound, alpha-asarone (1).
Antiviral immune responses in Itk-deficient mice (1997)

Mice lacking Itk, a T-cell-specific protein tyrosine kinase, have reduced numbers of T cells and reduced responses to allogeneic major histocompatibility molecules. This study analyzed antiviral immune responses in mice deficient for Itk. Primary cytotoxic T-lymphocyte (CTL) responses were analyzed after infection with lymphocytic choriomeningitis virus (LCMV), vaccinia virus (VV), and vesicular stomatitis virus (VSV). Ex vivo CTL activity was consistently reduced by a factor of two to six for the different viruses. CTL responses after restimulation in vitro were similarly reduced unless exogenous cytokines were added. In the presence of interleukin-2 or concanavalin A supernatant, Itk-deficient and control mice responded similarly. Interestingly, while LCMV was completely eliminated by day 8 in both Itk-deficient and control mice, VV cleared from itk-/- mice with delayed kinetics. Antibody responses were evaluated after VSV infection. Both the T-cell-independent neutralizing immunoglobulin M (IgM) and the T-cell-dependent IgG responses were similar in Itk-deficient and control mice. Taken together, the results show that CTL responses are reduced in the absence of Itk whereas antiviral B-cell responses are not affected.
Performance Improvement of Multimedia flows by using UDP-Lite and ROUC compression (2006)

The use of ROHC (robust header compression) over low bandwidth and noisy links saves bandwidth and reduces packet loss by decreasing the probability of header corruption. Nevertheless, the packets can still be dropped if errors occur in payload. To counter this problem, the applications can use error resilient coders and in addition can use UDP-Lite protocol which allows applications to have partially damaged payload rather than discarded. Multimedia applications will benefit from the use of both ROHC and UDP-Lite. Both mechanisms reduce the number of packets dropped and improve the quality of multimedia flows. In this paper we compare and study the proposed strategies for using UDP-Lite with ROHC. Our results show significant improvements in the performance of multimedia flows
PHOTOVOLTAIC EFFECT IN PbxSn1−xTe DIODES (1966)

Photovoltaic response has been observed in p-n junctions of PbxSn1−xTe at wavelengths up to 9.5 μ at 77°K and up to 12 μ at 12°K. These results together with previous photoluminescence data and the proposed model for the band structure of PbxSn1−xTe (ref. 1) indicate that these alloys have considerable potential for efficient infrared detection throughout the 8 to 14 μ atmospheric window and well beyond.
Calibration for a Hybrid MIMO Near-field Imaging System to Mitigate Antennas Effects (2020)

A calibration method for a high-resolution hybrid MIMO turntable radar imaging system is presented. A line of small metal balls is used in the calibration process to measure the position shift caused by undesired effects of the antennas. The unwanted effects in the near-field antenna response are analysed and significantly mitigated based on the referential features of the MIMO configuration.
Preliminary Results of the Luna Aneurysm Embolization System in a Rabbit Model: A New Intrasaccular Aneurysm Occlusion Device (2010)

The Luna AES achieved high rates of complete angiographic occlusion and showed promising histologic findings in the rabbit aneurysm model.
Assessment of methods for improving tracer estimation of non-steady-state rate of appearance (1999)

The most common approach for estimating substrate rate of appearance (R(a)) is use of the single-pool model first proposed by R. W. Steele, J. S. Wall, R. C. DeBodo, and N. Altszuler. (Am. J. Physiol. 187: 15-24, 1956). To overcome the model error during highly non-steady-state conditions due to the assumption of a constant volume of distribution (V), two strategies have been proposed: 1) use of a variable tracer infusion rate to minimize tracer-to-tracee ratio (TTR) variations (fixed-volume approach) or 2) use of two tracers of the same substrate with one infused at a constant rate and the other at a variable rate (variable-volume approach or approach of T. Issekutz, R. Issekutz, and D. Elahi. Can. J. Physiol. Pharmacol. 52: 215-224, 1974). The goal of this study was to compare the results of these two strategies for the analysis of the kinetics of glycerol and glucose under the non-steady-state condition created by a constant infusion of epinephrine (50 ng. kg(-1). min(-1)) with the traditional approach of Steele et al., which uses a constant infusion and fixed volume. The results showed that for glucose and glycerol the estimates of R(a) obtained with the constant and the variable tracer infusion rate and the equation of Steele et al. were comparable. The variable tracer infusion approach was less sensitive to the choice of V in estimating R(a) for glycerol and glucose, although the advantage of changing the tracer infusion rate was greater for glucose than for glycerol. The model of Issekutz et al. showed instability when the ratio TTR(1)/TTR(2) approaches a constant value, and the model is more sensitive to measurement error than the constant-volume model for glucose and glycerol. We conclude that the one-tracer constant-infusion technique is sufficient in most cases for glycerol, whereas the one-tracer variable-infusion technique is preferable for glucose. Reasonable values for glucose R(a) can be obtained with the constant-infusion technique if V = 145 ml/kg.
ERRATUM: “ISM MASSES AND THE STAR FORMATION LAW AT Z = 1 TO 6 ALMA OBSERVATIONS OF DUST CONTINUUM IN 145 GALAXIES IN THE COSMOS SURVEY FIELD” (2016, ApJ, 820, 83) (2016)

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