gebhart/patrepeval huggingface dataset:
Organic compound occurrence in fluids from ultramafic-hosted hydrothermal systems of the Mid-Atlantic ridge: a consequence of H2 production? (2008)

A characteristic phenomenon that occurs at slow spreading ridge, e.g. the Mid-Atlantic Ridge, is the formation of large faults, which at some place results in lifting up of the mantle rocks up to the ocean floor. Ultramafic-hosted hydrothermal systems are precisely located on these mantle outcrops, where circulation of seawater along the faults alters the periodites that mainly compose the mantle. The process known as serpentinisation results the production of a large amount of H2, which is a great source of energy for further chemical reactions such as methane and heavier hydrocarbons production. High concentration of CH4 detected in the water column above ultramafic-hosted hydrothermal fields has indeed been suggested to be the abiogenic product of a Fisher-Tropsh synthesis (3H2 + CO  CH4 + H2O), which is supported by the carbon isotopic data. This has lead to the idea of abiogenic formation of larger organic compounds such as hydrocarbons or key molecules for the origin of life issue. Both thermodynamics and laboratory work support this idea, but field data have been lacking up to date. Our study will present results on the organic content of hydrothermal fluids from 6 ultramafic-hosted hydrothermal fields of the MAR. Fluids were collected at Rainbow, Lost City, Logachev I & II and Ashadze I & II during the EXOMAR and the SERPENTINE cruises conducted by IFREMER, France. Innovative and efficient techniques have been developed, used and improved to concentrate, isolate and extract compounds from the fluids by SPE (Solid Phase Extraction)-GC-MS. Organics were listed and all compounds present in deep seawater and blank experiments were discarded as considered contaminants. The remaining appeared to be mainly hydrocarbons and oxygen-bearing compounds that were clearly -identified by comparison of recorded mass spectra with library data.This work is carried out partly within the MoMARnet (Monitoring deep sea floor hydrothermal environments on the Mid-Atlantic Ridge: A Marie Curie Research Training network) framework.
Spotted cotton oligonucleotide microarrays for gene expression analysis (2007)

The cotton oligonucleotide microarray provides a reproducible platform for transcription profiling in cotton, and is made publicly available through http://cottonevolution.info.
Review of liquid metal heat pipe work at Los Alamos (1990)

A survey of space-power related liquid metal heat pipe work at Los Alamos National Laboratory is presented. Heat pipe development at Los Alamos has been on-going since 1963. Heat pipes were initially developed for thermionic nuclear-electrical power production in space. Since then Los Alamos has developed liquid metal heat pipes for numerous applications related to high temperature systems in both the space and terrestrial environments. Some of these applications include thermionic electrical generators, thermoelectric energy conversion (both in-core and direct radiation), thermal energy storage, hypersonic vehicle leading edge cooling, and heat pipe vapor laser cells. Some of the work performed at Los Alamos has been documented in internal reports that are often little-known. A representative description and summary of progress in space-related liquid metal heat pipe technology is provided followed by a reference section citing sources where these works may be found. 53 refs.
Extraction and Analysis of Beta-carotene Recovery in CPO and Oil Palm Waste by Using HPLC (2016)

Beta-carotene is known to have a high demand in food industry which has made global industry to face challenges &#13;\nespecially in fulfilling customers’ requirement that are looking for ‘‘environment friendly’’ and natural products. This has opened up wide opportunities in utilizing crude palm oil (CPO) and oil palm waste (OPW) as natural sources of beta-carotene. Thus, present study explains recovery of beta-carotene from CPO and OPW of palm pressed fiber (PPF) and empty fruit bunch (EFB). Initially, crude oil from solid OPW samples was extracted by soxhlet extraction. Then, recovered oil from both PPF and EFB along with CPO were used to extract palm carotene. Extraction of beta-carotene from CPO and OPW were performed by using soxhlet adsorption method. High performance liquid chromatography (HPLC) analysis revealed beta-carotene a a major carotene in extracted samples. Results obtained indicated that 3790 ppm of beta-carotene extracted from CPO, 1414 ppm from PPF and 702 ppm from EFB by this soxhlet adsorption method.
Radical addition fragmentation chain transfer (RAFT) polymerization of ferrocenyl (Meth)acrylates (2012)

We report on the controlled free radical homopolymerization of 1-ferrocenylethyl acrylate as well as of three new ferrocene bearing monomers, namely 4-ferrocenylbutyl acrylate, 2-ferrocenylamido-2-methylpropyl acrylate, and 4-ferrocenylbutyl methacrylate, by the RAFT technique. For comparison, the latter monomer was polymerized using ATRP, too. The ferrocene containing monomers were found to be less reactive than their analogues free of ferrocene. The reasons for the low polymerizability are not entirely clear. As the addition of free ferrocene to the reaction mixture did not notably affect the polymerizations, sterical hindrance by the bulky ferrocene moiety fixed on the monomers seems to be the most probable explanation. Molar masses found for 1-ferrocenylethyl acrylate did not exceed 10,000 g mol-1, while for 4-ferrocenylbutyl (meth)acrylate molar masses of 15,000 g mol-1 could be obtained. With PDIs as low as 1.3 in RAFT polymerization of the monomers, good control over the polymerization was achieved. © 2011 Wiley Periodicals, Inc.
Dentin phosphoprotein sequence motifs and molecular modeling: conformational adaptations to mineral crystals (1998)

Molecular modeling has been used to investigate structural features of oligopeptides derived from possible primary structure motifs in highly phosphorylated dentin phosphoprotein (PP-H), the predominant noncollagenous protein in dentin. It contains a large number of aspartate (Asp) and phosphoserine (Pse) residues, the latter proposedly crucial for the PP-H function as a mineral nucleator. In this work, computer fitting and subsequent structural adaptation of model peptides, built exclusively from Asp and Pse, to the known crystal structures of hydroxyapatite (HAP) and octacalcium phosphate (OCP) were performed. The results show that, when considering conformational energies of fitted single strand oligo-peptides, either crystal will serve. Within a narrow range, fitting to OCP was slightly favored, except for oligo(Pse-Pse-Asp-Asp), which showed a slightly better fit to HAP. Energy differences between crystal-adapted and non-adapted freely minimized peptides showed that oligo(Pse-Asp) docked to either HAP or OCP were the energetically most favored adaptations. Fitting of minimized triple anti-parallel beta-strands of oligo(Pse-Asp) or oligo(Pse-Pse-Asp), motifs found in published sequences of rat, mouse, and bovine PP-H, revealed that a (001) crystal face of HAP, but most likely not OCP, may be formed by these beta-sheet models. The former motif is more advantageous in this respect.
Abstract 15054: Genome Wide Association Study of Coronary Microvascular Disease Assessed by Cardiac Perfusion Positron Emission Tomography (2022)

Introduction: Coronary Microvascular Disease (CMVD), defined as disease of the coronary pre-arterioles, arterioles, and capillaries, accounts for 30-50% of the burden of ischemic heart disease. However, little is known about the pathogenesis, and there are no directed therapies for CMVD. Perfusion cardiac PET allows for the quantitative assessment of myocardial blood flow (MBF) at rest and stress and MBF reserve (MBFR) and represents the most clinical advanced non-invasive imaging modality for CMVD. Hypothesis: Here we perform the first genome-wide association study (GWAS) for CMVD using cardiac PET MBF parameters. Methods: Rest and stress MBF and MBFR were measured using Rubidium-82 cardiac perfusion PET stress tests which were obtained as part of routine clinical care. We performed a GWAS in 383 samples of European (EUR) and 539 samples of African ancestry (AFR) in the Penn Medicine Biobank using MBF values and REGENIE software. Models were adjusted for age, sex, age 2 , age x sex, 5 principal components, and batch corresponding to phenotype extraction. Additionally fine mapping was performed for loci with P-value &lt; 1e-05 using implementation of SuSiE in the polyfun package by integrating gene expression and functional annotations from heart ventricular, atrium, aorta, and coronary artery tissues in the EpiMap database. Results: We identified 10 variants in AFR ancestry for MBFR at p-value &lt; 5e-7. Among the top hits, our results identified novel signals in variants mapping to LOC105374051, UNC13A, RPL21P130, ATP6V0A2, CCSER1, and MDFI , among others. We also identified 4 variants in AFR and 1 in EUR for rest MBF and 3 variants in AFR and 1 in EUR for stress MBF phenotypes, including loci near ARHGAP18 and ARHGAP22 . Fine mapping identified 4 loci in AFR for MBFR including NRP1, ERC1, RN7SKP148, and SCL15A4 . In sex-stratified analyses, we found that variants were more strongly associated with PET-derived MBF phenotypes in AFR women than in AFR men and in EUR men relative to EUR women. Conclusions: Our study identified several variants associated with perfusion PET MBF parameters in populations of EUR and AFR ancestry, some of which represent putative CMVD loci. This work yields novel insights into mechanisms of CMVD.
Understanding Methane Aromatization on a Zn‐Modified High‐Silica Zeolite (2008)

Es gehören zwei dazu: Ein hoher Konversionsgrad für den Einbau der 13C-Atome von Methan in die Produkte einer Methan/Propan-Coaromatisierung am Zeolith Zn/H-BEA wurde durch 13C-Festkörper-NMR-Spektroskopie und GC-MS nachgewiesen. Isotopenmarkierungsexperimente zum Mechanismus ergaben, dass zunächst aus Propan gebildete aromatische Spezies methyliert werden, worauf eine Ringexpansion/-kontraktion folgt (siehe Schema).
Superconducting Properties of Crystalline Ultrathin Films (1973)

We present measurements of the superconducting transition temperature of ultrathin aluminum films grown epitaxially on silicon. The transition temperature is found to be near the bulk ${T}_{c}$ and is significantly lower than that found in disordered films. Some initial experiment on growing epitaxial Pb films on PbTe are also discussed.
Let's Make a Deal: Negotiating Resolution of Intellectual Property Disputes Through Mandatory Mediation at the Federal Circuit, 6 J. Marshall Rev. Intell. Prop. L. 365 (2007) (2007)

In 2006, the United States Court of Appeals for the Federal Circuit implemented a mandatory mediation program for parties in all counseled cases, including intellectual property disputes. This program offers the parties incentives to settle, such as providing neutral mediators with intellectual property expertise at no cost to the litigants. This article explains how the Federal Circuit’s Mediation Program works and provides an overview of the Guidelines. This article concludes that the Federal Circuit firmly stands behind the mandatory mediation program for intellectual property disputes and believes the process can only serve to benefit all parties involved.
Role of Radiotherapy in Adrenocortical Carcinoma (2013)

This report is one of the largest to date examining the role of modern radiation techniques in the management of ACC. We conclude that radiation can be effective in the management of metastatic ACC, palliating local symptoms, and preventing complications from large metastases. Radiation should be considered as an option in multimodality management of ACC patients.
Anionic Liposomes Enhance and Prolong Adenovirus-Mediated Gene Expression in Airway Epithelia in Vitro and in Vivo (2011)

Adenoviral vector mediated gene therapy has received extensive attention in airway disease treatment. However, the lack of the requisite coxsackie-adenovirus receptor (CAR) on the apical surface of airway epithelium and the host immune response to adenoviruses limit their in vivo application. In our study, we developed for the first time a novel formulation composed of anionic liposomes and adenoviruses (AL-Ad5) using a calcium-induced phase change method. The obtained formulation was employed to enhance the transduction efficiency of airway gene delivery. Our results indicated that primary cultured airway epithelial cells infected by AL-Ad5 displayed higher LacZ gene expression compared to naked adenovirus. Importantly, AL-Ad5 significantly improved and prolonged LacZ gene expression in murine airway tissues when delivered in vivo by intratracheal instillation. Additionally, it was found that anionic liposomes provided immunoprotection to the adenovirus from neutralizing antibody, thus slowing down the elimination of Ad5 particles meanwhile reducing the inflammatory reaction caused by the Ad5 vector. These results suggested that the combination of anionic liposomes with adenovirus may be a useful strategy to deliver therapeutic genes into the airway epithelia and is promising in clinical application.
Early Wildfire Smoke Detection Based on Motion-based Geometric Image Transformation and Deep Convolutional Generative Adversarial Networks (2019)

Early detection of wildfire smoke in real-time is essentially important in forest surveillance and monitoring systems. We propose a vision-based method to detect smoke using Deep Convolutional Generative Adversarial Neural Networks (DC-GANs). Many existing supervised learning approaches using convolutional neural networks require substantial amount of labeled data. In order to have a robust representation of sequences with and without smoke, we propose a two-stage training of a DCGAN. Our training framework includes, the regular training of a DCGAN with real images and noise vectors, and training the discriminator separately using the smoke images without the generator. Before training the networks, the temporal evolution of smoke is also integrated with a motion-based transformation of images as a pre-processing step. Experimental results show that the proposed method effectively detects the smoke images with negligible false positive rates in real-time.
Antitumorigenic effect of plumbagin by induction of SHP1 in human gastric carcinoma cell lines. (2015)

74 Background: Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) is a plant-drived natural agent extracted from the root of Plumbago zeylanic. A recent study reported that plumbagin down-regulated the activity of Janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) pathway to show various anti-tumor effects. We aimed in this in vitrostudy to demonstrate the inhibition of JAK2-STAT3 pathway by plumbagin through inducing SH2-containing protein tyrosine phosphatase 1 (SHP1) expression in gastric cancer cell line. Methods: We performed Wetern blot to measure SHP1, phospho-JAK2/STAT3 level, and reverse transcriptase-polymerase chain reaction (RT-PCR) to evaluate target gene expression of STAT3. Several functional studies such as water soluble tetrazolium-1 (WST-1) assay, wound closure assay and matrigel invasion assay were also performed. Results: Plumbagin induced SHP1 expression and simultaneously down-regulated phospho-JAK2/STAT3 level via dose-and time-dependant manner in MKN28 cell, a gastric carcinoma cell line which has negative SHP1 expression. This effect was consistent when JAK2-STAT3 signaling was activated by interleukin-6, and ameliorated when cells were treated with prevanadate, a protein tyrosin phosphatase inhibitor. Furthermore, plumbagin significantly reduced gene expression of cyclin D1, VEGF1, survivin, MMP9, known target products of STAT3 activation in gastric cancinogenesis. The functional effect of plumbagin could be validated as inhibition of cell proliferation, migration and invasion, which are the results of activation of JAK2-STAT3 pathway in gastric cancer cells. Conclusions: Plumbagin is a potential negative regulator of cellular growth, migration and invasion by inhibiting both constitutive and inducible STAT3 activity through induction of SHP1 in gastric cancer cells.
Comparing a Bottleneck Identification Tool with the Congested Traffic Pattern Recognition System ASDA/FOTO Using Archived Freeway Data from Portland, Oregon (2009)

Bottlenecks are key features of any freeway system and represent the emerging location for recurrent and non-recurrent traffic congestion. In Oregon, a freeway data archive known as PORTAL records volume, occupancy, and speed measurements from over 600 freeway locations every 20 seconds. This archive has enabled development of online freeway performance and reliability analysis tools. This paper describes a comparison of an automated tool for identifying recurrent freeway bottlenecks, using historical data within the framework of the data archive, with the ASDA/FOTO models based on Kerner’s three-phase traffic theory as an approach for traffic data processing. Both approaches use graphical tools to illustrate the occurrence of bottlenecks with congested patterns. Ultimately the results of this joint research will improve the prioritization of improvements and implementation of operational strategies on the freeway network, especially in cases of congested bottlenecks.
Treatment effects and comorbid diseases in 58 patients with visual snow (2019)

This study provides Class IV evidence that for some patients with visual snow, lamotrigine resulted in partial remission of symptoms.
Two subsets of epithelial cells in the thymic medulla. (1992)

Information was sought on the features of epithelial cells in the murine thymic medulla. The expression of major histocompatibility complex (MHC) molecules on medullary epithelium was defined by light microscopy with the aid of bone marrow chimeras and MHC-transgenic mice. A proportion of medullary epithelial cells was found to show conspicuously high expression of conventional MHC (H-2) class I (K, D, L) and class II (I-A, I-E) molecules. These cells express a high density of the Y-Ae epitope, a complex of an E alpha peptide and I-Ab molecules found on typical bone marrow-derived cells. MHC+ medullary epithelial cells show limited expression of I-O molecules, a class of atypical nonpolymorphic MHC-encoded class II molecules present on B cells. Other medullary epithelial cells express a high density of I-O molecules but show little or no expression of typical MHC class I or II molecules. MHC and I-O expression thus appear to subdivide medullary epithelial cells into two phenotypically distinct subsets. This applies in adults. In the embryonic thymus most medullary epithelial cells express both types of molecules.
Comparison of Argon Triple Point between NIS-Egypt and LNE-INM/CNAM-France (2008)

This paper describes the results of a bilateral comparison of the triple point of argon (83.8058 K), one of the defining fixed points on the ITS-90 and the lowest temperature fixed point used in the calibration of the long-stem Standard Platinum Resistance Thermometers (SPRTs) used in most national metrological institutes (NMIs), as realized and maintained at the National Institute of Standards Egypt (NIS) and Institut Nationale de Metrologie - France (LNE-INM/CNAM). The main objective of this work was to compare the realizations of the argon triple-point cells for longstem thermometers and to establish the level of agreement between the results from the two laboratories. The comparison measurements revealed a slightly higher temperature of the NIS argon Constant Heat Flux (CHF-device) than that of the LNE-INM/CNAM device by about 0.2 mK. The difference found is significantly smaller than its expanded combined uncertainty (coverage factor k = 2). The detailed analysis of the results and the uncertainty budget related to the measurements are presented. Calculation of the normalized error ratio (NER) gave a value of 0.25 ≤ 1 which shows that the measurements at the two laboratories are compatible.
Free fatty acid metabolism in fetal and newborn sheep (1960)

The metabolism of free fatty acids (FFA) was studied in the term ewe, sheep fetus and newborn lamb. The concentration of FFA is about 10 times greater and the concentration of triglyceride fatty acids (TGFA) 2 1/2 times greater in maternal than in fetal plasma. After intravascular administration of palmitic acid-1-C 14 complexed to homologous albumin, the initial rates of disappearance of FFA radioactivity from maternal and fetal circulations were similar, with half-times of approximately 2 minutes. Radioactivity appeared in the opposite circulation as FFA indicating that the syndesmochorial placenta is permeable to palmitic acid. Survival of the newborn lamb is associated with a fivefold increase in plasma concentration of FFA and no significant change in glucose or fructose during the first 30 minutes after birth. Failure to survive is associated with lack of increase in plasma FFA concentrations, while glucose concentrations do not differ from those found in surviving lambs. These data suggest that sympathetic nervous system activity is responsible for the FFA elevation and that increased activity of the sympathetic nervous system or FFA mobilization is closely related to survival of the newborn lamb.
Effect of surfaces on fluid-phase prekallikrein activation (1981)

The activation of prekallikrein by factor XII fragments (XIIf), during incubation in plastic tubes was previously noted to be increased by high molecular weight (HMW) kininogen as well as other plasma proteins. In this report, we investigated the mechanism responsible for this increase. Although we confirmed that HMW kininogen, bovine serum albumin, fibrinogen, cold insoluble globulin, and mixed phospholipids apparently increased prekallikrein activation, we found that the product of prekallikrein activation (kallikrein) lost substantial activity in less than 0.5 min after exposure to a variety of fresh surfaces. This loss was partially prevented by the presence of various proteins and phospholipids. Similar protection against inactivation of XIIf, the enzyme in this reaction, was also found. In contrast, no loss of the substrate, prekallikrein, was observed during incubation. The loss of kallikrein activity was found to be proportional to the surface area of the incubation vessel as well as the concentration of kallikrein. Further loss of kallikrein activity could also be prevented by pretreating the vessel with kallikrein. We therefore conclude that various substances apparently affect prekallikrein activation in a purified system by preventing the enzyme and product in the reaction mixture from losing activity due to adsorption to a surface.