gebhart/patrepeval huggingface dataset:
D2.2 Site facilities planning (2018)

The present deliverable describes the planning of each site facility deployment at least until April 2019. It also gives some perspectives of updates that will occur after this date. April 2019 has been put at the first objective since it corresponds to the initial access to the site facility for vertical hosting. Attached to this deliverable, we have inserted an Excel file, with one sheet per site facility, giving the dates of availability for each component/equipment that compose the integrated site facility. These components are referred via index number in the Excel sheet, showing their date of availability. Then, in the document, a brief description of each component is done as well as its methodology of implementation, testing and validation. More attention is paid about the site facility integration. Indeed, since some site facilities are composed of several integrated platforms regarding the use case they want to host, each integrated platform is detailed about the components they are composed of, the KPI they plan to achieve and the methodology of integration they plan to apply.<br> The content of this document is complementary to the 5G EVE deliverable D2.1 [1], which describes more in details the various site facilities. We just refer or take inputs coming from [1] to give information about the site facilities architectures and components that integrate the platforms. Therefore, reading first [1] is a prerequisite to better understand this document.
ChemInform Abstract: Inhibition of Nav1.6 Sodium Channel Currents by a Novel Series of 1,4‐Disubstituted‐triazole Derivatives Obtained via Copper‐Catalyzed Click Chemistry. (2013)

ChemInformVolume 44, Issue 7 Heterocyclic Compounds ChemInform Abstract: Inhibition of Nav1.6 Sodium Channel Currents by a Novel Series of 1,4-Disubstituted-triazole Derivatives Obtained via Copper-Catalyzed Click Chemistry. Mirko Rivara, Mirko Rivara Dip. Farm., Univ. Studi Parma, I-43124 Parma, ItalySearch for more papers by this authorManoj K. Patel, Manoj K. Patel Dip. Farm., Univ. Studi Parma, I-43124 Parma, ItalySearch for more papers by this authorLaura Amori, Laura Amori Dip. Farm., Univ. Studi Parma, I-43124 Parma, ItalySearch for more papers by this authorValentina Zuliani, Valentina Zuliani Dip. Farm., Univ. Studi Parma, I-43124 Parma, ItalySearch for more papers by this author Mirko Rivara, Mirko Rivara Dip. Farm., Univ. Studi Parma, I-43124 Parma, ItalySearch for more papers by this authorManoj K. Patel, Manoj K. Patel Dip. Farm., Univ. Studi Parma, I-43124 Parma, ItalySearch for more papers by this authorLaura Amori, Laura Amori Dip. Farm., Univ. Studi Parma, I-43124 Parma, ItalySearch for more papers by this authorValentina Zuliani, Valentina Zuliani Dip. Farm., Univ. Studi Parma, I-43124 Parma, ItalySearch for more papers by this author First published: 22 February 2013 https://doi.org/10.1002/chin.201307114Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume44, Issue7February 12, 2013 RelatedInformation
A platelet cloak for tumor cells (2004)

Comment on Palumbo et al, page [178][1] 

Palumbo and colleagues show that platelets and fibrinogen protect metastatic tumor cells from elimination by NK cells, confirming a striking mechanistic link between activation of the blood coagulation system and the spread of tumor metastases. 

Tumor cells
Ideal Cycle Evaluation of Steam Augmented Gas Turbines (1996)

A wide range of air-standard Brayton and modified-Brayton power cycles are evaluated to determine their second-law efficiencies and their volume flows per unit output. A cycle with reheating is chosen for further analysis on the basis of its potential for high efficiency through exploitation of its exhaust availability (exergy) and its low volume rates. This exploitation can be had either through a conventional Rankine bottoming cycle, or through injection of the bottoming cycle steam into the Brayton turbine. The Rankine bottoming cycle is superior with respect to second-law efficiency; the cycle augmented by injected steam is superior with respect to volume flows. Examination of irreversibilities illuminates the reasons for the better efficiency of the Rankine bottoming cycle alternative.
Experimental IgA nephropathy. (1979)

An animal model for IgA immune complex nephritis was developed. IgA immune complexes formed in vitro with an IgA anti-dinitrophenyl (DNP) derived from MOPC-315 plasmacytoma, and dinitrophenylated bovine serum albumin (DNP-BSA) produced mild focal glomerulonephritis in mice. Similar, but more severe pathological changes were produced with complexes formed in vivo either in normal mice or MOPC-315 tumor-bearing mice. In contrast to the focal nature of the PAS-positive glomerular lesions observed by light microscopy, immunofluorescent examination revealed IgA deposits in all glomeruli. This discrepancy between immunofluorescent and histopathologic findings as well as the distribution of the immune complexes within the affected glomeruli, are some of the features which bear resemblance between this experimental model and human IgA nephropathy. Fixation of complements by DNP-BSA-IgA immune complexes, formed in vitro or in vivo, was shown to occur in the glomeruli of mice with IgA immune complex nephropathy. The pattern of C3 glomerular deposits was similar to that of IgA. However, complement proved to be nonessential for complex deposition. This conclusion is based on the observation that decomplemented mice, although showing no deposition of C3 in their glomerulus, developed glomerular immunohistological changes similar to those observed in experimental mice that were not decomplemented. Polymeric IgA was observed to be critical for renal deposition of complexes and induction of nephritic histological changes. In contrast, monomeric IgA immune complexes failed to produce glomerular deposits. This finding raises the possibility that secretory IgA, which is predominantly polymeric, may play a role in human IgA-associated glomerulonephritis.
Assessment of lipid profile of peritoneal fluid for differential ascites diagnostics (2017)

The problem of differential ascites diagnostics in different patients remains urgent for modern surgery. Apart from well known methods, authors propose an original algorithm for assessment of ascetic fluid. The main element of such studies is the determination of a lipid spectrum of ascetic fluid and content of lipid components in cell structures. 260 samples were examined which were obtained from patients having examination and treatment in the General Surgery Clinic of the Kirov Military Medical Academy (St. Petersburg). For examination of ascetic fluid, the methods of cytological analysis of ascitic fluid centrifugate were used, its cytochemical examination, as well a complex of biochemical methods: determination of the total protein, amylase, chylomicrons, triglycerides; bacterial inoculation was made. It has been shown that the ratio of chylomicrons, lipoproteins and cytosis permits a more precise differentiation of ascites type which influences the selection of further treatment program especially in chyloperitoneum and lymphatic ascites.
The (±) Reference: Accuracy of Estimated Mean Components in Average Response Studies (1967)

The (+/-) reference is defined as the result of alternate addition and subtraction and division by N (the number of sample functions). Under suitable conditions both the (+/-) reference and the variable component (noise) of the usual average tend to be derived from the same Gaussian process, and the former can be used as a measure of the latter. This property is most easily applied when the noise is derived from a stationary process. Application of the (+/-) reference and the average of the square of the voltage in studies of evoked response is discussed.
Potential acoustic techniques for monitoring mass flowrate in coal-air ducts (1984)

Among the main complications of the post-liver transplant patient, we can highlight that all patients presented at least one infectious complication (100%), vascular complications in 31% and biliary complications in 31.25% of patients.
Digital vs. All-Optical Networking in Packet-Optical Integrated Transport: a Lifecycle Cost-Benefit Analysis (2011)

A cost-benefit analysis of packet optical network approaches based on digital and all-optical ROADM respectively was performed. Cost, power consumption and flexibility with respect to different traffic distributions and loads have been compared.
Nephrogenic diabetes insipidus. A V2 vasopressin receptor unable to stimulate adenylyl cyclase (1993)

The coding region of the human vasopressin type 2 receptor gene bears mutations in the individuals affected with congenital nephrogenic diabetes insipidus, a disease characterized by the inability of the kidney to concentrate urine in response to vasopressin. Although it is assumed that the mutations result in loss of receptor function, proof of this hypothesis is lacking. We introduced one of these naturally occurring point mutations leading to a single amino acid change (Arg137-->His) into wild type cDNA. The mutant protein was expressed, and the functional properties of the receptor were examined. The mutant receptor exhibited an unaltered binding affinity for vasopressin compared to the wild type but failed to stimulate the Gs/adenylyl cyclase system. These data provide biochemical proof that the mutant receptor is the cause of the disease.
Mobilité atomique dans les silicates vitreux et fondus (2014)

This manuscript deals with the coupled diffusion in an industrial glass system containing four oxides (SiO2, Al2O3, CaO, Na2O). The temperature range extends from the glass transition temperature (650°C) to the liquidus (1200°C). The first results concern the macroscopic nature of diffusion. The matrix containing the diffusion coefficients quantifies the mobility of the components and highlights many interactions between them. Other information can be obtained at the microscopic scale. The exchange equations summarize the main diffusion paths followed by the system in reactions form. All the data from the literature are processed and they seem to converge towards preferential diffusion paths. Hypothesis about the mechanisms of diffusion of the species are proposed. The results obtained at low temperatures open a discussion of the relationship between transport properties and diffusion. The study of the structure of the material was based on Raman spectroscopy. Diffusion experiments provide a large number of glass compositions, which allowed us to develop a statistical tool for handling spectra. The spectral components thus obtained are discussed in the light of the many observations described in the literature. This approach allowed us to interpret the components through correlations between their relative intensities and the composition of the material and by studying their evolution along the diffusion profiles. The possibility of a Raman spectroscopy technique for quantifying species is discussed.
The design and implementation of the first low-income, shared-savings weatherization program: A Wisconsin pilot program (1998)

In 1997 the State of Wisconsin began searching for low-income programs that were innovative in their approach and which offered the potential to improve or expand program delivery. TecMRKT Works responded to this call with an RFP to implement the first shared-savings pilot weatherization program in the US. This paper describes the program being tested in Wisconsin and presents some of the early lessons learned.
Role of Fermi-Level Pinning in Nanotube Schottky Diodes (2000)

At semiconductor-metal junctions, the Schottky barrier height is generally fixed by "Fermi-level pinning." We find that when a semiconducting carbon nanotube is end contacted to a metal (the optimal geometry for nanodevices), the behavior is radically different. Even when the Fermi level is fully "pinned" at the interface, the turn-on voltage is that expected for an unpinned junction. Thus the threshold may be adjusted for optimal device performance, which is not possible in planar contacts. Similar behavior is expected at heterojunctions between nanotubes and semiconductors.
Echinolactone A and B: isolation and structures of two novel lactones from the marine coelenterate Echinopora lamellosa (1984)

Two novel pentacyclic triterpenes were isolated from the marine coelenterate Echinopora lamellose; their structures and absolute configuration (determined from spectroscopic and X-ray diffraction data) are reported.
t ‐ZrO 2 toughened Al 2 O 3 free‐standing films and as oxidation mitigating thin films on silicon nitride via colloidal processing of flame made nanopowders (NPs) (2020)

Abstract Zirconia toughened aluminas (ZTAs) are one of the most important engineering ceramics with high melting points, excellent mechanical strength, and chemical stability, and are commonly used as wear resistant and high‐temperature components, as prosthetic implants, and electric circuit substrates. In this work, we explore methods of processing fine‐grained, dense, thin, free‐standing (ZrO 2 ) x (Al 2 O 3 ) 1− x films ( x = 0‐50 mol%, ~40 μm thick) by sintering flame made nanopowders (NPs) to optimize the t ‐ZrO 2 content, sinterability, and microstructures under select conditions (1120°C‐1500°C/5 h in O 2 or 95%N 2 /5%H 2 ). In all cases, the final sintered products retain t‐ ZrO 2 with average grain sizes (AGSs) of 0.1‐1 μm. ZTA film thicknesses were increased to ~200 μm to assess potential as electronic substrates. Excellent fracture toughness (24 MPa m 1/2 ) and small AGSs of 0.7 μm were found for ~200 μm thick ZTA films sintered at 1500°C/5 h/N 2 /H 2 using a three‐step binder burnout process. Furthermore, we show that homogeneous ZTA thin films (&lt;5 μm thick) can be sintered on Si 3 N 4 substrates (thickness ≈ 300 μm) to provide physical protection against oxidation under extreme conditions (1500°C/1 h/O 2 ), offering additional practical utility for high‐temperature ceramics and power electronic substrates.
ω-3 fatty acid treatment in cardiac syndrome X (2013)

Four months of therapy with a moderate dose of ω-3 fatty acids improved the endothelial function and reduced oxidative stress in patients with CSX.
FDTD Formulation for Graphene Modeling Based on Piecewise Linear Recursive Convolution and Thin Material Sheets Techniques (2014)

A finite-difference time-domain formulation based on piecewise linear recursive convolution method and on thin material sheets technique is developed for modeling terahertz graphene antennas and some other photonic components. The graphene sheets are modeled by specific recursive equations obtained for tangential electric field components, allowing one to easily apply voltage or current sources between the sheets. The effective conductivity of graphene sheets in Yee's three-dimensional lattice is calculated and used in simulations. A bow-tie-like geometry is investigated, aiming at resonance tuning. The developed numerical formulation is validated by comparison of results to data published in literature.
Total syntheses of (+)-7-epi-goniofufurone, (+)-goniopypyrone and (+)-goniofufurone from a common precursor (2007)

Total syntheses of (+)-7-epi-goniofufurone, (+)-goniopypyrone and (+)-goniofufurone have been achieved from an advanced common precursor formed from D-(+)-mannitol by changing the carbinol protection profile.
Phonon damping in thin films of Fe (1999)

The phonon density of states (DOS) in thin films of polycrystalline α-Fe was measured by inelastic nuclear resonant scattering of synchrotron radiation. The thin-film DOS exhibits significant deviations from the DOS of bulk Fe, which we attribute to phonon lifetime broadening in the confined geometry. The measured DOS can be described with a damped harmonic oscillator model for the phonons with different quality factors Q=25(2) and Q=13(1) for layer thicknesses of 28 and 13 nm, respectively.
Discriminatory genomic fingerprinting of Legionella pneumophila by pulsed-field electrophoresis (1994)

Eight strains of Legionella pneumophila were used to optimize cleavage of DNA with BssHII, SalI, or SpeI and separation by pulsed-field electrophoresis. Isolates from a community outbreak involving a contaminated hot tub were genomically identical. Cleavage patterns were distinctly different for unrelated environmental and nosocomial strains from a single hospital.
Analytical and Experimental Investigation of Temporal Interference for Selective Neuromuscular Activation (2020)

This article presents an analytical method that offers both spectral and spatial information to predict local electric fields capable of driving neural activities for neuromuscular activation, and the findings of an experimental investigation on a common strategy utilizing multiple high-frequency (HF) electric fields to create an interference to recruit neural firing at depth. By introducing a cut-off frequency [Formula: see text] too high to recruit neural firing in a frequency-based field descriptor, the analytical method offers an effective means to position a focused temporal interference (TI) without mechanically moving the electrodes. The experiment, which was conducted on both forearms of five healthy volunteers, validates the feasibility of the method for selective neuromuscular stimulation, where three nerve/muscles that control human fingers were independently stimulated with two current channels. The numerical and experimental findings demonstrate that the frequency-based method overcomes several limitations associated with surface-based electrical stimulation.
Supplementary Table 1 from <i>CUL3</i> and <i>NRF2</i> Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma (2023)

&lt;p&gt;XLSX file - 186K, Somatic mutation in PRCC2&lt;/p&gt;
Functional Role of ADP-Ribosyl-Acceptor Hydrolase 3 in poly(ADPRibose) Polymerase-1 Response to Oxidative Stress (2016)

Poly-ADP-ribosylation has been proposed to be a reversible protein modification, participating in diverse cellular functions including DNA repair, chromatin remodeling, genetic stability, mitosis, and cell death. Poly-ADP-ribosylation is initiated by the transfer of the ADP-ribose moiety of NAD+ primarily to the carboxyl groups of glutamate and aspartate and amino group of lysine residues in target proteins, followed by elongation of poly(ADP-ribose) (PAR) chains via α-O-glycosidic (C- 1"-C-2') ribose-ribose bonds. PAR consists of polymers of ADP-ribose (up to 200 units) with branching via α-O-glycosidic (C-1"'-C-2") ribose-ribose bonds. Further, the pyrophosphate group of each ADP-ribose has two negative charges. Therefore, in proteins modified by PAR, a complex structure with negative charges may lead to dynamic changes of functions. PAR formation is catalyzed by poly(ADP-ribose) polymerases (PARPs) and terminated by several types of enzymes with PAR-degrading activities; poly(ADP-ribose) glycohydrolase (PARG), ADP-ribosylacceptor hydrolase (ARH) 3, ARH1, and macrodomain-containing proteins. PARG has been thought to be primarily responsible for PAR degradation. In 2006, ARH3 was cloned and identified as another type of PAR-degrading protein. Although PAR-degrading activity of ARH3 is less than that of PARG, different mechanisms of PAR recognition and the cellular localization of ARH3 appear to be responsible for unique cellular roles of ARH3 involving PAR. In the present review, we focused on our findings regarding structure, biological properties, and cellular functions of ARH3. In addition, we describe the current knowledge of poly-ADP-ribosylation and cell death pathways regulated PARP1, PARG, and ARH3.
Convergence of meningeal and facial afferents onto trigeminal brainstem neurons: an electrophysiological study in rat and man (1999)

Headache is often accompanied by referred pain in the face. This phenomenon is probably due to a convergence of afferent inputs from the meninges and the face onto central trigeminal neurons within the medullary dorsal horn (MDH). The possible existence and extent of this convergence was examined in rat and man. MDH neurons activated by stimulation of the parietal meninges were tested for convergent tactile and noxious mechanical input from all three facial branches of the trigeminal nerve. All 21 units with meningeal input could also be activated by facial stimuli. Brush stimuli applied to the supraorbital nerve area activated 86%, to the infraorbital nerve area 29%, and to the mental nerve area none of the units. Pinch stimuli applied to the supraorbital nerve area activated 95%, to the infraorbital nerve area 86%, and to the mental nerve area 52% of the units. The results suggest convergence of meningeal and facial inputs concentrated on the supraorbital nerve in rat. In man convergence was examined by probing neuronal excitability of MDH applying the blink reflex (BR) during Valsalva maneuver which probably increases intracranial pressure. The BR evoked by supraorbital nerve stimulation remained unchanged, while the BR evoked by mental nerve stimulation was significantly facilitated. This facilitation may be due to convergence of meningeal and facial inputs onto trigeminal neurons in man.
A cross-sectional study of the nasal and fecal microbiota of sows from different health status within six commercial swine farms (2021)

This study provided baseline information for nasal and fecal microbiota of sows under field conditions, and results suggest that farm of origin can affect microbial diversity and composition. Furthermore, sow's health status may have an impact on the nasal microbiota composition.
Comparative effects of histone deacetylase inhibitors on p53 target gene expression, cell cycle and apoptosis in MCF-7 breast cancer cells (2011)

Histone deacetylase inhibitors are currently being evaluated for their therapeutic potential and have shown considerable promise as adjuvant therapies for a number of cancers. This study compared the effects of 2 hydroxamic acid based inhibitors, CG-1521 and SAHA, on gene expression, cell cycle and cell death in MCF-7 human breast cancer cells. Both compounds show a dose- and time-dependent effect on cell number (evaluated using crystal violet), however CG-1521 exerts its effects significantly earlier than SAHA, and CG-1521 induces apoptosis (assessed by Apo-BrdU staining and flow cytometry) more rapidly than SAHA. qPCR of cell cycle regulatory and apoptotic genes shows that CG-1521 and SAHA modulate similar cohorts of p53-responsive genes, however, the levels of induction and the timing of the induction differs significantly between the 2 inhibitors. In particular SAHA downregulates cell cycle-associated genes that modulate the G1/S transition (including cyclin D1 and cdc25a) and the G2/M transition [cyclin B1, Plk1, Stk6 (serine-threonine kinase 6, Aurora kinase A) and Kntc2] more significantly than CG-1521. In contrast, CG-1521 significantly induces the expression of several p53 target genes associated with apoptosis including Bnip3/Bnip3L, p21/p21B and Gdf15. The differential levels of gene induction provide molecular evidence of both cell cycle arrest and apoptosis, and suggest a molecular mechanism that explains the difference in the biological effects of the 2 histone deacetylase inhibitors.
Is Candida stellatoidea disappearing from the vaginal mucosa? (1990)

A total of 681 vaginal isolates of germ tube-positive or germ tube-untested white, yeastlike fungi obtained from patients in various cities of the United States were tested for the presence of Candida stellatoidea (type I). Only 1 of the 681 isolates was identified as C. stellatoidea.