gebhart/patrepeval huggingface dataset:
Case Study: First Reported Case of Interferon-alpha Induced Postural and Action Tremor (P4.074) (2014)

OBJECTIVE: Our goal is to report a previously unknown side effect of pegylated interferon-alpha causing action and postural tremor during treatment for hepatitis C. BACKGROUND: Interferon alpha is associated with many neurological complications. Even though a variety of movement disorders, such as Parkinsonism, chorea, restless leg syndrome and dystonia, have been described with interferon use, to our knowledge, this is the first described case of both rest and action tremor. DESIGN/METHODS/RESULTS: We present a case study of a 58 year-old male who developed titubation and upper extremity resting and action tremor 20 weeks after initiation of therapy with pegylated interferon-alpha. The tremor progressively worsened with ongoing therapy and stabilized but did not resolve when therapy was discontinued 8 weeks later. CONCLUSIONS: Tremor should be recognized as a possible side-effect of interferon-alpha and should be a consideration for therapy cessation as the sequelae may be protracted (as in our case) or even permanent.
Corticosteroid treatment of experimental smoke inhalation (1976)

The Journal of Trauma: Injury, Infection, and Critical Care: May 1976 - Volume 16 - Issue 5 - p 420
Decomposition of aquatic biota and sediment formation: bound lipids in algal detritus and lake sediments (1979)

SUMMARY. Organic detritus resulting from microbial attack on algal material contains lipids directly extractable by organic solvents and also contains bound lipids, obtained by solvent extraction following acid hydrolysis. Differences between the composition of bound and extractable n‐alkanes, n‐ and branched/cyclic alkanoic acids from each source are attributed to a major bacterial input to these bound lipid classes. Similarities in composition between bound lipid classes of algal detritus and corresponding classes in a lake sediment support earlier suggestions of a considerable bacterially‐derived contribution to sedimentary bound lipids.
Echocardiographic and Clinical Response to Cardiac Resynchronization Therapy in Heart Failure Patients with and without Previous Right Ventricular Pacing (2014)

Despite similar ejection fraction pre-CRT, patients upgraded to CRT with previous RVp have smaller end-systolic volume and respond to CRT at least as well as, if not better than, other wide QRS heart failure patients. A greater improvement in ejection fraction and a lower risk of death or heart failure hospitalization when adjusted for baseline characteristics were seen in those with previous RVp.
A cell-free method for expressing and reconstituting membrane proteins enables functional characterization of the plant receptor-like protein kinase FERONIA (2017)

There are more than 600 receptor-like kinases (RLKs) in <i>Arabidopsis</i>, but due to challenges associated with the characterization of membrane proteins, only a few have known biological functions. The plant RLK FERONIA is a peptide receptor and has been implicated in plant growth regulation, but little is known about its molecular mechanism of action. To investigate the properties of this enzyme, we used a cell-free wheat germ-based expression system in which mRNA encoding FERONIA was co-expressed with mRNA encoding the membrane scaffold protein variant MSP1D1. With the addition of the lipid cardiolipin, assembly of these proteins into nanodiscs was initiated. FERONIA protein kinase activity in nanodiscs was higher than that of soluble protein and comparable with other heterologously expressed protein kinases. Truncation experiments revealed that the cytoplasmic juxtamembrane domain is necessary for maximal FERONIA activity, whereas the transmembrane domain is inhibitory. An ATP analogue that reacts with lysine residues inhibited catalytic activity and labeled four lysines; mutagenesis demonstrated that two of these, Lys-565 and Lys-663, coordinate ATP in the active site. Mass spectrometric phosphoproteomic measurements further identified phosphorylation sites that were examined using phosphomimetic mutagenesis. The results of these experiments are consistent with a model in which kinase-mediated phosphorylation within the C-terminal region is inhibitory and regulates catalytic activity. These data represent a step further toward understanding the molecular basis for the protein kinase catalytic activity of FERONIA and show promise for future characterization of eukaryotic membrane proteins.
Boomerang: Behind an Australian Icon (1996)

From Aboriginal history to kitschy souvenirs to the shelves of your local sports store, boomerangs have a fascinating place in history and popular culture. Author Philip Jones draws on the world's largest boomerang collection at the South Australian Museum to describe the boomerang's traditional uses and its more recent flight into western culture. Boomerang is an extensive pictorial guide to this unique Australian icon, covering its uses and traditional and contemporary history. Also included are sections on the boomerang in world sport, the physics of a returning boomerang, and instructions on how to make your own.Illustrated with over 100 full-colour photographs.
Supplementary Data from Targeting the PI3K/mTOR Pathway Augments CHK1 Inhibitor–Induced Replication Stress and Antitumor Activity in High-Grade Serous Ovarian Cancer (2023)

&lt;p&gt;Clean version of supplementary Data&lt;/p&gt;
Creatine kinase/α-crystallin interaction functions in cataract development (2020)

Creatine kinase (CK) is an energy storage enzyme that plays an important role in energy metabolism. CK/phosphocreatine functions as an energy buffer and links ATP production sites with ATP utilization sites. Several key mutations in the αA-crystallin (<i>cryaa</i>) and αB-crystallin (<i>cryab</i>) genes have been linked with autosomal-dominant, hereditary human cataracts. The cryaa-R49C mutation was identified in a four-generation Caucasian family. We previously identified an increase in the quantity of CK complexed with α-crystallin in the lenses of knock-in mice expressing the cryaa-R49C mutation using proteomic analyses. Increased levels of CK in postnatal cataractous lenses may indicate increased ATP requirements during early cataract development. To gain a further understanding of the relationship between CK and α-crystallin, we investigated whether α-crystallin interacts with and forms complexes with CK, <i>in vitro</i>. Isothermal titration calorimetry (ITC) showed that each CK dimer bound to 28 α-crystallin subunits, with a K<sub>d</sub> of 3.3 × 10<sup>-7</sup> M, and that the interaction between α-crystallin and CK was endothermic, thermodynamically favorable, and entropy-driven. High-salt concentrations did not affect the interaction between CK and α-crystallin, suggesting that the interaction between CK and α-crystallin is primarily hydrophobic. Gel permeation chromatography (GPC) detected water-soluble α-crystallin and CK complexes, as determined by increased light scattering after complex formation. In addition, CK and α-crystallin formed partially-water-insoluble, high-molecular-mass complexes. Enzyme-linked immunosorbent assay (ELISA)-based enzymatic activity analyses of lens homogenates showed a 17-fold increase in CK activity in the postnatal lenses of cryaa-R49C knock-in mice. These studies indicate that the interaction between α-crystallin and CK is functionally important and that increased CK levels may be necessary to meet the increased ATP demands of ATP-dependent functions in cataractous lenses.
Euthyroid Sick Syndrome: Is It a Misnomer? (1997)

Alterations in thyroid function tests are very common in patients with NTI. Multiple, complex, and incompletely understood mechanisms are involved in these abnormalities. Knowledge of these abnormalities is necessary to avoid errors in the diagnosis of thyroid disease. Measurement of serum TSH, free T4, and free T3 levels by direct equilibrium dialysis/RIA methods probably yield most useful (accurate) information in the setting of NTI. Patients with low free T4 by these methods and normal or low TSH have secondary hypothyroidism. This may be due to NTI per se, drugs administered for treatment of NTI, or associated pituitary or hypothalamic disease; the latter consideration may require evaluation of cortisol reserve, PRL, and/or gonadotropins. A serum TSH level above 20-25 microU/mL probably reflects primary hypothyroidism; accompanying findings of goiter, low free T4, and positive antithyroid antibodies help establish the diagnosis. An elevated serum concentration of rT3 argues against hypothyroidism. Studies have demonstrated no discernible benefit of treatment of NTI patients with T4. Some studies have shown a few benefits of treatment with T3 in selected cases, but much more needs to be learned. There is no evidence of harm by treatment of NTI patients with up to replacement doses of T3. As some NTI patients may indeed be hypothyroid, the term ESS should be replaced with NTIS.
Influence of Adrenergic Blocking Drug [N-Ethyl-N-(2-bromoethyl)-l-naphthylenemethylamine {middle dot} HBr] On Pyrogenic Reaction. (1949)

SummaryA potent adrenergic blocking drug, N-Ethyl-N- (2-bromoethy1)-1-naphthyl-enemethylamine · HBr, has been shown to reduce and alter the febrile response of normal and curarized dogs to the intravenous injection of a purified pyrogenic material obtained from pseudomonas aeruginosa. This evidence is interpreted as supporting the hypothesis that the pyrogenic reaction is due, at least in part, to a reduction in heat loss caused by adrenergic nerve mediated vasoconstriction in the skin.
Prediction of non-muscle invasive bladder cancer recurrence using machine learning of quantitative nuclear features (2021)

Non-muscle invasive bladder cancer (NMIBC) generally has a good prognosis; however, recurrence after transurethral resection (TUR), the standard primary treatment, is a major problem. Clinical management after TUR has been based on risk classification using clinicopathological factors, but these classifications are not complete. In this study, we attempted to predict early recurrence of NMIBC based on machine learning of quantitative morphological features. In general, structural, cellular, and nuclear atypia are evaluated to determine cancer atypia. However, since it is difficult to accurately quantify structural atypia from TUR specimens, in this study, we used only nuclear atypia and analyzed it using feature extraction followed by classification using Support Vector Machine and Random Forest machine learning algorithms. For the analysis, 125 patients diagnosed with NMIBC were used; data from 95 patients were randomly selected for the training set, and data from 30 patients were randomly selected for the test set. The results showed that the support vector machine-based model predicted recurrence within 2 years after TUR with a probability of 90% and the random forest-based model with probability of 86.7%. In the future, the system can be used to objectively predict NMIBC recurrence after TUR.
Pulsed-field ablation versus single catheter high-power short-duration radiofrequency ablation for atrial fibrillation: procedural characteristics, myocardial injury and midterm outcomes (2023)

Abstract Funding Acknowledgements Type of funding sources: None. Background Pulsed-field ablation (PFA) has emerged as a novel treatment strategy for patients with atrial fibrillation (AF). A direct comparison to high-power short-duration (HPSD) radiofrequency (RF) ablation using a single catheter is lacking. Aim To compare pulmonary vein isolation (PVI) using PFA versus single catheter HPSD-RF ablation regarding efficiency, safety, myocardial injury, and outcomes. Methods 119 patients underwent PVI and were included (age 65.6 ± 10 years, ejection fraction 0.55 ± 0.11, left atrial size 41 ± 6.6 mm, paroxysmal AF 55%). 56 patients (47%) underwent PFA using a multi-electrode pentaspline PFA catheter with a biphasic waveform and 63 patients (53%) underwent single catheter HPSD-RF ablation without a multipolar mapping catheter. Results Using PFA the median procedure time was significantly shorter compared to the single catheter HPSD-RF group with 58 (IQR 51-70) min versus 83 (IQR 71-99) min (p&amp;lt;0.001), while fluoroscopic time was significantly longer with 12 (IQR 10-16) min versus 2.2 (IQR 1.3-3.6) min (p&amp;lt;0.001). First-pass isolation was achieved in 91% of the PFA group and 88% in the HPSD-RF group. 3.3 catheters vs. 1.0 catheters were used in the PFA group versus the HPSD-RF group, p&amp;lt;0.01. One procedural complications was observed in the PFA group and one complication in the HPSD-RF group (Tamponades). High sensitivity cardiac troponin levels were on average significantly higher in patients using the PFA system, 1520 (IQR 1010-1980) ng/l compared to 897 (IQR 725-1240) ng/l in the HPSD-RF group. During a median follow-up of 177 days (IQR 92-300), AF recurrence was observed in five patients (9%) from the PFA group and in 15 patients (24%) from the HPSD-RF group. (Figure 1) Conclusion PFA showed shorter procedure times but longer fluoroscopy times, higher levels of hs cTnT, and a possible improved AF-free survival.
Comparative cis‐regulatory analyses identify new elements of the mouse Hoxc8 early enhancer (2004)

The Hoxc8 early enhancer is a 200 bp region that controls the early phase of Hoxc8 expression during mouse embryonic development. This enhancer defines the domain of Hoxc8 expression in the neural tube and mesoderm of the posterior regions of the developing embryo. Five distinct cis-acting elements, A-E, were previously shown to govern early phase Hoxc8 expression. Significant divergence between mammalian and fish Hoxc8 early enhancer sequences and activities suggested additional cis-acting elements. Here we describe four additional cis-acting elements (F-I) within the 200 bp Hoxc8 early enhancer region identified by comparative regulatory analysis and transgene-mutation studies. These elements affect posterior neural tube and mesoderm expression of the reporter gene, either singly or in combination. Surprisingly, these new elements are missing from the zebrafish and Fugu Hoxc8 early enhancer sequences. Considering that fish enhancers direct robust reporter expression in transgenic mouse embryos, it is tempting to postulate that fish and mammalian Hoxc8 early enhancers utilize different sets of elements to direct Hoxc8 early expression. These observations reveal a remarkable plasticity in the Hoxc8 early enhancer, suggesting different modes of initiation and establishment of Hoxc8 expression in different species. We postulate that extensive restructuring and remodeling of Hox cis-regulatory regions occurring in different taxa lead to relatively different Hox expression patterns, which in turn may act as a driving force in generating diverse axial morphologies.
Metal Fuel Casting Simulation (Annual Report) (2011)

Continuing work to develop the capability to simulate metallic fuel fabrication at Idaho National Laboratory (INL) is presented in this report.Simulations using the Truchas code developed at LANL and the commercial software package FLOW3D were used to evaluate the capabilities necessary for modeling mold filling and solidification of the bench scale caster (BSC).The results suggest that surface tension and the pressure effects of the argon in the mold must both be included in the simulation to obtain results that are qualitatively similar to the experimentally observed rod size and morphology.Effects of viscosity of the liquid metal seem to be relatively unimportant.The possibility of flow of partially solidified material is examined, and may be important for the flow conditions in the BSC.A more general discussion of software requirements is included for casting processes that are suitable for metallic fuel rods.A comparison of current capabilities of Truchas and FLOW3D is presented.Neither of the two codes has all the capabilities needed, and future work will probably use both software packages.A performance and scaling evaluation of FLOW3D indicates that adequate performance can be obtained for this project using multiprocessor hardware.
Accelerating ripening of greenhouse tomatoes in autumn at the end of harvest with ethylene application (2017)

Accelerating maturation of greenhouse tomatoes at the end of the growing season permits to save energy and to reduce the quantity of unripe tomatoes. Indeed, at the end of the cropping season, several kg m-2 of tomatoes do not reach a degree of maturity permitting them to be sold. In Switzerland, it was possible to accelerate the ripening of tomatoes by applying ethephon, a product which releases ethylene. Since August 2014, this product is no longer authorized, in Switzerland. An alternative is the application of ethylene, a naturally occurring hormone, directly in the greenhouse. In collaboration with the company Carbagas, Agroscope tested the effect of ethylene application on tomato ripening. The trials were conducted in 2012 and 2013 in two identical compartments of a Venlo greenhouse. In one compartment, ethylene was injected at a concentration of 10 ppm during nine or ten nights. The other compartment served as control. In 2012, tomatoes 'Levanzo', 'Komeett' and 'Endeavour' were planted and in 2013 'Endeavour'. In average over the two years, the application of ethylene enabled to harvest 1.5 truss m-2 or 0.75 kg m-2 (1.5% of the total yield) more compared to the control compartment. The quality of tomatoes at harvest (acidity, firmness and total soluble substances) was only slightly influenced by the addition of ethylene. Economically, such an application seems profitable. Registration for the application of ethylene in greenhouse is in progress in Switzerland.
Biochemical and histochemical studies of biogenic amines in spinal cord trauma (1976)

Highly sensitive enzymatic assays, microdissection techniques, and histochemical methods were used to investigate the effects of blunt trauma on rabbit spinal cord serotonin, norepinephrine, and dopamine concentrations. Within 5 minutes after trauma, norepinephrine and serotonin in gray matter decreased considerably at the lesion center. In white matter, norepinephrine decreased or was unchanged, but at the lesion edges serotonin increased. No changes in dopamine concentration were detected. Substantial changes in monoamines do occur after spinal cord trauma and serotonin may play a role in injury development.
Observation of exclusive dijet production at the Fermilab Tevatronp¯pcollider (2008)

We present the first observation and cross section measurement of exclusive dijet production in p̄p interactions, p̄p→p̄+dijet+p. Using a data sample of 310pb-1 collected by the Run II Collider Detector at Fermilab at s=1.96TeV, exclusive cross sections for events with two jets of transverse energy ETjet≥10GeV have been measured as a function of minimum ETjet. The exclusive signal is extracted from fits to data distributions based on Monte Carlo simulations of expected dijet signal and background shapes. The simulated background distribution shapes are checked in a study of a largely independent data sample of 200pb-1 of b-tagged jet events, where exclusive dijet production is expected to be suppressed by the Jz=0 total angular momentum selection rule. Results obtained are compared with theoretical expectations, and implications for exclusive Higgs boson production at the pp Large Hadron Collider at s=14TeV are discussed. © 2008 The American Physical Society.
Heat‐ and light‐induced thiol‐ene oligomerization of soybean oil‐based polymercaptan (2018)

ABSTRACT Polymercaptanized soybean oil (PMSO), the product of a thiol‐ene reaction between soybean oil and hydrogen sulfide, is a material of interest as a lubricant additive and polymer precursor. We investigated with gel permeation chromatography, nuclear magnetic resonance (one‐dimensional and two‐dimensional), gas chromatography–mass spectrometry, and viscometry the changes that occur with PMSO upon heating or ultraviolet irradiation. The observed changes were due to a further thiol‐ene reaction between the thiol groups and the residual unsaturation. The formation of oligomers was a result of new sulfide bridges. Additionally, tetrahydrothiophene moieties were detected. An almost linear increase of the average molecular weight (MW) and the polydispersity index (PDI) was observed upon heat treatment [number‐average MW ( ) = 1180 Da, PDI = 1.32 for PMSO, = 1720 Da, PDI = 2.17 for PMSO that was heated for 1000 h at 130 °C]. PDI correlated best with the z ‐average MW. The was the best predictor of the viscosity. For samples with close , the higher PDI corresponded to a higher viscosity index. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46150.
Enhancing hybrid metal-semiconductor systems beyond SERS with PIERS (photo-induced enhanced Raman scattering) for trace analyte detection (2020)

Hybrid metal-semiconductor systems are promising substrates for field Raman analysis due to their ability to use both electromagnetic and chemical enhancement pathways for surface enhanced Raman spectroscopy (SERS). Photo-induced Raman spectroscopy (PIERS) has previously been shown to be a promising method utilizing an additional enhancement route through photo-inducing atomic surface oxygen vacancies in photocatalytic metal-oxide semiconductors. The photoinduced vacancies can form vibronic coupling resonances, known as charge transfers, with analyte molecules, enhancing the signal beyond conventional SERS enhancements. However, conventional UV sources most often used for excitation of the PIERS substrate are impractical in combination with portable Raman systems for field analysis. In this work we show how a small UVC LED, centered at 255 nm, can replicate the same results previously reported with the benefit of allowing greater in-situ real time measurements under constant UV exposure. The UV LED source can be controlled more easily and safely, making it a practical UV source for field PIERS analysis.
Reconstruction in the Labeled Stochastic Block Model (2015)

The labeled stochastic block model is a random graph model representing networks with community structure and interactions of multiple types. In its simplest form, it consists of two communities of approximately equal size, and the edges are drawn and labeled at random with probability depending on whether their two endpoints belong to the same community or not. It has been conjectured in \cite{Heimlicher12} that correlated reconstruction (i.e.\ identification of a partition correlated with the true partition into the underlying communities) would be feasible if and only if a model parameter exceeds a threshold. We prove one half of this conjecture, i.e., reconstruction is impossible when below the threshold. In the positive direction, we introduce a weighted graph to exploit the label information. With a suitable choice of weight function, we show that when above the threshold by a specific constant, reconstruction is achieved by (1) minimum bisection, (2) a semidefinite relaxation of minimum bisection, and (3) a spectral method combined with removal of edges incident to vertices of high degree. Furthermore, we show that hypothesis testing between the labeled stochastic block model and the labeled Erdős-Rényi random graph model exhibits a phase transition at the conjectured reconstruction threshold.