gebhart/patrepeval huggingface dataset:
Metabolic and tissue residue studies on parbendazole in sheep (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetabolic and tissue residue studies on parbendazole in sheepC. John. DiCuollo, James A. Miller, Wilford L. Mendelson, and Joseph F. PaganoCite this: J. Agric. Food Chem. 1974, 22, 6, 948–953Publication Date (Print):November 1, 1974Publication History Published online1 May 2002Published inissue 1 November 1974https://pubs.acs.org/doi/10.1021/jf60196a049https://doi.org/10.1021/jf60196a049research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
La educación en medios de comunicación ante el reto de la televisión digital (2003)

La Educacion en Materaa de Comunicacion ante el reto de la television parte de un hecho constatado: el modelo mediatico organizado en torno a la television digital es producto de las transformaciones que estan sufriendo nuestras sociedades, y a su vez da origen en si mismo a importantes cambios en el panorama de la comunicacion. La Educacion en Materia de Comunicacion (EMC), en su objetivo de formacion critica de la ciudadana para el uso y consumo responsable de la comunicacion y sus medios en compromiso en la realidad existente, debe evolucionar con los medios de comunicacion que se desarrollan en la sociedad. En esta tesis nos preguntamos si la EMC en Espana, en el anos 2003, esta integrando ya a la television digital, un medio con una importante presencia en nuestros hogares. Para ello realizamos un analisis exhaustivo de la configuracion de este nuevo medio en nuestro pais, y desde esa informacion estudiamos el grado de conocimiento que existe sobre el en el seno de la EMC y la atencion consecuente que se le presta. Con toda la informacion extraida llegamos a la conclusion de que existe un conocimiento muy parcial de la EMC en Espana respecto a la television digital, y de que apenas esta siendo atendida. A partir de ahi realizamos nuestras propias propuestas de integracion, tomando a la television digital como medio idoneo para el estudio de los contextos de transformacion en que estamos viviendo.
A hypothesis testing approach to word recognition using dynamic feature selection (2003)

A top-down approach to word recognition is proposed. Discussions are presented on dynamically selecting the most effective feature combinations, which are applied to discriminate between a limited set of word hypotheses.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Recent developments in automated structure elucidation of natural products (2004)

Advancements in the field of Computer-Assisted Structure Elucidation (CASE) of Natural Products achieved in the past five years are discussed. This process starts with a dereplication procedure, supported by structure-spectrum databases. Both commercial and free products are available to support the procedure. A number of new programs,as well as advancements in existing ones, are presented. Finally, the option to validate the result by an independent procedure, a high quality ab initio quantum mechanical calculation, is discussed.
SRI Best Practices (2005)

Although the Methodist church of the United Kingdom began to use social screening based on “sin” stocks in the 1920s, it wasn9t until the 1960s that socially responsible investing (SRI) was adopted by religious groups in continental Europe. Today there are many lessons we can learn from the Europeans. They include expanding the requirements of boards of directors to include a more comprehensive knowledge of business and expansion of negative screens for companies who have not been doing SRI as a easy step to implementing it.
P563Relevance of C3-complement activation in atherosclerotic plaques and in the lipid-loaded smooth muscle cell phenotype (2018)

junctions, prior to stretching and enlargement of the endothelial cell, followed by alignment around a larger lumen. Conversely, loss of VE-cadherin and inhibition of actin prevented lumen remodelling. Conclusion: Arterial Flt1 by titrating arterial Vegfa regulates the caliber of arterioles during de novo arteriologenesis involving a unique sequence of collective endothelial cell behaviors and actin remodeling events. Plgf and Vegfb, by shifting the Flt1-Vegfa binding equilibrium toward Vegfa release, promote arteriologenesis. Our model suggests that arterial Flt1 may be used as a local cargo to deliver safe Vegfa dosages in revascularization strategies.
Controlled fabrication of hierarchically microstructured surfaces via surface wrinkling combined with template replication (2015)

在这份报纸，我们在场由联合表面起皱和模板复制在 polydimethylsiloxane (PDMS ) 上创造一系列层次结构的一个简单方法弹性体。主要稳定的衬里的模式被与 PDMS 复制商品化的紧缩的磁盘和数字万用的磁盘形成。第二等的 microscale 模式从表面起皱，它被 prestrained PDMS 邮票的血浆(OP ) 处理与 prestrain 版本跟随了的氧得到。由系统地改变 OP 暴露持续时间， prestrain，和角度() 在主要模式取向和 prestrain 方向之间，我们从不同 patterning 技术并且与不同长度规模和机械稳定性获得高度订的组织良好的合成模式。
What is the Profitability of a Photovoltaic Installation in France for an Individual? (2023)

The energy transition will require the use of renewable energy resources that will allow us to reach our decarbonization objectives. In addition to states and institutions, individuals have an important role to play in this transition, particularly with the installation of photovoltaic panels. But for individuals to use this source of energy, they must be guaranteed a financial return that encourages them to take the plunge. Several companies, in a commercial approach, guarantee returns on investment after 2–3 years for any installation. But is the financial profitability always guaranteed? In France, several types of photovoltaic installations are possible, total resale and self-consumption. For each one, the profitability will vary and depends on many parameters such as the initial and daily investment, the irradiation, the electricity buy-back price, and the consumption. This paper explains the calculation methodology for both typologies and shows that currently, in most cases, a self-consumption installation is more profitable than a full resale installation but is far from obtaining the returns on investment predicted by the commercials. If self-consumption is more profitable today, this is due to the fact that the investment (initial or annual) is less important, and that the price of electricity becomes more and more expensive while at the same time the price of resale decreases from year to year.
Crowd behavior detection by statistical modeling of motion patterns (2010)

The governing behaviors of individuals in crowded places offer unique and difficult challenges, and limit the scope of conventional surveillance systems. In this paper, we investigate the crowd behaviors and localize the anomalies due to individual's abrupt dissipation. The novelty of the proposed approach can be described in three aspects. First, we introduce block-clips by sectioning the video segments into non-overlapping spatio-temporal patches to marginalize the arbitrarily complicated and dense flow field. Second, we treat the flow field in each block-clip as 2d distribution of samples and mixtures of Gaussian is used to parameterize it keeping generality of flow field intact. K-means algorithm is employed to initialize the mixture model and is followed by Expectation Maximization for optimization. These mixtures of Gaussian result in the distinct flow patterns precisely a sequence of dynamic patterns for each block-clip. Third, a bank of Conditional Random Field model is employed one for each block clip and is learned from the sequence of dynamic patterns and classifies each block-clip as normal and abnormal. We conduct experiment on two challenging benchmark crowd datasets PETS 2009 and University of Minnesota and results show that our method achieves higher recognition rates in detecting specific and overall crowd behaviors. In addition, the proposed approach shows dominating performance during the comparative analysis with similar approaches in crowd behavior detection.
Seismic Tests of Precast Beam-to-Column Joint Subassemblages With Unbonded Tendons (1996)

Two ungrouted post-tensioned, precast concrete beam-to-column joint subassemblages were tested under cyclic reversals of inelastic displacement to determine seismic response. One subassemblage represented an exterior joint while the other was an interior joint of a one-way prestressed concrete frame. The large scale test units were designed with greatly reduced beam and joint shear reinforcement compared with equivalent monolithic joints, but with special spiral confinement of the beam plastic hinge regions. Both subassemblages performed well, with only minor, cosmetic damage being recorded up to drift ratios of 3 percent or more. Energy absorption of the hysteretic response, though small, was larger than expected and residual displacements were negligible. It is concluded that satisfactory seismic performance can be expected from well-designed ungrouted precast, post-tensioned concrete frames.
Selective plane illumination microscopy with structured illumination based on spatial light modulators (2014)

Structured-illumination microscopy (SIM) is an efficacious tool to decrease the contribution of the out-of-focus light to images of specimens. However, in SIM, the frequency of the spatial modulation applied to specimens should be adjustable according to the optical properties of the specimens to reach the optimal contrasts. Hence, a common theme in SIM is how the flexibility and quality of modulations at different frequencies can be improved. Digital scanned laser light-sheet microscopy with structured illumination (DSLM-SI) has been the most flexible means for generating modulation and optical sectioning. The complexity of synchronization between the temporal modulation and the beam scanning makes it hard to use and less stable; it also takes more time to acquire images for one plane than selective plane illumination microscopy (SPIM). In this report, we present a recent effort to use a spatial light modulator (SLM) to provide spatial modulation in SPIM. With the SLM, both of the frequency and phase of lateral modulation can be changed rapidly; moreover, this SLM-based SPIM can achieve fast imaging without mechanical moving parts.
In Vitro Characterization and Stability Profiles of Antibody–Fluorophore Conjugates Derived from Interchain Cysteine Cross-Linking or Lysine Bioconjugation (2019)

Fluorescent labelling of monoclonal antibodies (mAbs) is classically performed by chemical bioconjugation methods. The most frequent labelling technique to generate antibody-fluorophore conjugates (AFCs) involves the bioconjugation onto the mAb lysines of a dye bearing an <i>N</i>-hydroxysuccinimide ester or an isothiocyanate group. However, discrepancies between labelling experiments or kits can be observed, related to reproducibility issues, alteration of antigen binding, or mAb properties. The lack of information on labelling kits and the incomplete characterization of the obtained labelled mAbs largely contribute to these issues. In this work, we generated eight AFCs through either lysine or interchain cysteine cross-linking bioconjugation of green-emitting fluorophores (fluorescein or BODIPY) onto either trastuzumab or rituximab. This strategy allowed us to study the influence of fluorophore solubility, bioconjugation technology, and antibody nature on two known labelling procedures. The structures of these AFCs were thoroughly analyzed by mass spectroscopy, and their antigen binding properties were studied. We then compared these AFCs in vitro by studying their respective spectral properties and stabilities. The shelf stability profiles and sensibility to pH variation of these AFCs prove to be dye-, antibody- and labelling-technology-dependent. Fluorescence emission in AFCs was higher when lysine labelling was used, but cross-linked AFCs were revealed to be more stable. This must be taken into account for the design of any biological study involving antibody labelling.
Resonant and nonresonant funneling through plasmonic gratings in the limit of the aperture width approaching zero (2014)

We experimentally and theoretically investigate electromagnetic funneling in thick plasmonic gratings as the aperture size approaches zero. Both resonant and nonresonant funneling mechanisms were observed to provide near unity transmission for aperture widths of ∼λ/100. As the apertures become smaller, the resonant funneling process enters into a region of strong absorption followed by complete reflection. In sharp contrast, the broadband, nonresonant funneling mechanism continues to transmit energy at high levels for screens of &amp;lt;1% open area and apertures sizes as small as λ/1500 before finally transitioning to a completely absorbing state without any abatement of the funneling into the apertures.
Influence of high voltage harmonics on partial discharge patterns modulation (2014)

Typically, in laboratory and diagnostics tests focused on measuring partial discharges, a pure sinusoidal voltage waveform is assumed. However, in practice the spectral content of the applied voltage is rarely so ideal and additional spectral components have a significant impact on the discharge behavior in electrical insulation systems. In this paper the influence of voltage harmonics on partial discharge behavior and pattern evolution is analyzed. The presented experiments were conducted on specimens representing various defects in high voltage insulation system, in the form of protrusion, inclusion, delamination. The experimental results showed that various harmonic compositions superimposed on the fundamental sinusoidal waveform have a significant impact on PD intensity and maximal charge. In consequence, PD pattern phase and amplitude distributions are distorted and calculated statistical parameters are changed. The rough parameters reflecting the waveform spectral quality, such as THD, are rather superficial and do not provide a unique and reliable signature of the applied voltage in terms of phase angle variations. In certain environments, neglecting harmonic content in the voltage may lead to a misleading interpretation and assessment of partial discharge severity. A complete knowledge of harmonic content is essential and critical in conducting a proper assessment of the impact of PD, including acceptability criteria and compatibility with the standards.
Hardness vs Randomness for Bounded Depth Arithmetic Circuits (2018)

In this paper, we study the question of hardness-randomness tradeoffs for bounded depth arithmetic circuits. We show that if there is a family of explicit polynomials {f_n}, where f_n is of degree O(log^2n/log^2 log n) in n variables such that f_n cannot be computed by a depth Delta arithmetic circuits of size poly(n), then there is a deterministic sub-exponential time algorithm for polynomial identity testing of arithmetic circuits of depth Delta-5. This is incomparable to a beautiful result of Dvir et al.[SICOMP, 2009], where they showed that super-polynomial lower bounds for depth Delta circuits for any explicit family of polynomials (of potentially high degree) implies sub-exponential time deterministic PIT for depth Delta-5 circuits of bounded individual degree. Thus, we remove the "bounded individual degree" condition in the work of Dvir et al. at the cost of strengthening the hardness assumption to hold for polynomials of low degree. The key technical ingredient of our proof is the following property of roots of polynomials computable by a bounded depth arithmetic circuit : if f(x_1, x_2, ..., x_n) and P(x_1, x_2, ..., x_n, y) are polynomials of degree d and r respectively, such that P can be computed by a circuit of size s and depth Delta and P(x_1, x_2, ..., x_n, f) equiv 0, then, f can be computed by a circuit of size poly(n, s, r, d^{O(sqrt{d})}) and depth Delta + 3. In comparison, Dvir et al. showed that f can be computed by a circuit of depth Delta + 3 and size poly(n, s, r, d^{t}), where t is the degree of P in y. Thus, the size upper bound in the work of Dvir et al. is non-trivial when t is small but d could be large, whereas our size upper bound is non-trivial when d is small, but t could be large.
Data from A Phase I Dose–Escalation Study of Regorafenib (BAY 73–4506), an Inhibitor of Oncogenic, Angiogenic, and Stromal Kinases, in Patients with Advanced Solid Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Regorafenib is a novel oral multikinase inhibitor of angiogenic (VEGFR1-3, TIE2), stromal (PDGFR-β, FGFR), and oncogenic kinases (KIT, RET, and RAF). This first-in-man, phase I dose–escalation study assessed the safety, pharmacokinetic, pharmacodynamic, and efficacy profiles of regorafenib in patients with advanced solid tumors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Patients and Methods:&lt;/b&gt; Patients aged 18 years or older with advanced solid tumors refractory to standard treatment were recruited. Regorafenib was administered orally for 21 days on/seven days off in repeating cycles, until discontinuation due to toxicity or tumor progression. Adverse events (AE) were assessed using National Cancer Institute Common Terminology Criteria for Adverse Events v3.0. Pharmacokinetic profiles were measured after a single dose and on day 21. Pharmacodynamic and efficacy evaluations included tumor perfusion assessment using dynamic contrast-enhanced MRI, plasma cytokines, and tumor response using RECIST (v1.0).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Fifty-three patients were enrolled into eight cohorts at dose levels from 10 to 220 mg daily. The recommended dose for future studies was determined to be 160 mg daily, with a treatment schedule of 21 days on/seven days off in repeating 28-day cycles. The most common drug-related grade 3 or 4 AEs were dermatologic AEs (hand–foot skin reaction, rash), hypertension, and diarrhea. Pharmacokinetic analysis revealed a similar exposure at steady state for the parent compound and two pharmacologically active metabolites. Tumor perfusion and plasma cytokine analysis showed biologic activity of regorafenib. Three of 47 evaluable patients achieved a partial response (renal cell carcinoma, colorectal carcinoma, and osteosarcoma).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; Regorafenib showed an acceptable safety profile and preliminary evidence of antitumor activity in patients with solid tumors. &lt;i&gt;Clin Cancer Res; 18(9); 2658–67. ©2012 AACR.&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Homogenisation Metamodelling of Perforated Plates (2004)

Abstract: The use of finite element (FE)‐based homogenisation has improved the study of composite material properties. However, it involves enormous computational effort when implemented in engineering design problems. Therefore an artificial neural network (ANN) surrogate model is proposed here to avoid this issue. In this study, a numerical homogenisation code was developed based on a commercial FE package. It is used to develop the ANN metamodel for an individual composite structure. The effectiveness of the metamodel was examined through an analytical optimisation procedure.
LMAP: a protocol to automate the setup of logical networks (2003)

This paper presents the logical membership announcement protocol (LMAP), a new signaling protocol that handles the construction of logical topologies (e.g. overlay networks) in a straightforward way. LMAP defines both a way to disseminate membership information into the network and a way to determine the adjacencies that must be established between members to create the logical topology. LMAP represents a building block for upper-layer distributed services (e.g. virtual private networks, BGP peering, and more) that rely on a logical topology to achieve their functionality. Moreover, appropriate protocol extensions can be used to transport information that is meaningful only to the service application. This paper presents the key points behind LMAP, it describes how LMAP works, it makes a comparison with other proposals, and it shows some preliminary results proving its robustness and its excellent scalability.
Cytotoxicity of Graphene Oxide (GO) and Graphene Oxide Conjugated Losartan Potassium (GO-LP) on Neuroblastoma (NB41A3) Cells (2018)

Despite several advancements in the biomedical sciences, an efficient cancer therapy still remains a challenge. Nanomedicines have shown potential to overcome certain roadblocks faced in the existing treatment modalities. Losartan potassium (LP) which is a known vasodilator also exhibits anti fibrolytic and anti-metastatic properties altogether. Further, also being a potential angiotensin II type 1 receptor antagonist, it has been well explored for down regulating tumourogenic biomarkers like VEGF-A (Vascular endothelial growth factor A) and suppression of neovascularization, making it a suitable drug to target for cancer treatment. Besides this, it too reflected the stimulation of pro apoptotic signaling pathways. But due to its lower bioavailability and extensive hepatic metabolism its therapeutic index reduces down. Thus, the present study is focused on designing a nano-delivery system using graphene oxide (GO) as a nano-vehicle and conjugated the LP with it. Then, the successful synthesis of GO and GO-LP nano conjugates were characterized by high-resolution transmission electron microscopy, X-ray diffraction, FTIR and UV visible spectroscopy, confirming the formation of nanosheets. The qualitative morphological evaluation of NB41A3 neuroblastoma cell line treated with bare GO, LP and GO-LP using microscopy and DAPI staining revealed the inhibitory action of GO-LP nano conjugate on cell proliferation. Additionally, the cytotoxicity was also estimated using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), Nitric oxide (NO) and Lactate dehydrogenase (LDH) assays. The results show that GO-LP significantly suppresses the cell viability in comparison to control and bare GO suggesting that the designed system may express its potential to be used with existing chemo drugs for the treatment of neural cancers.