gebhart/patrepeval huggingface dataset:
Renal Function in Patients on Lithium Treatment (1979)

Summary A cross-sectional study was performed on 66 lithium-treated patients to investigate a possibly changed kidney function, using [ 51 Cr]-EDTA clearance, and urinary excretions of albumin and β 2 -microglobulin. Thirteen patients showed abnormal test results: seven had decreased glomerular filtration rate, four had increased albumin excretion and four had increased excretion of β 2 -microglobulin. There was no correlation between length of treatment with lithium or hypothyroidism (10 patients) and impaired renal function. Four patients had already manifested signs of renal dysfunction before lithium treatment. The high prevalence of impaired renal function among our patients is unexplained but lithium could be one possible cause.
Electron microscopy of nickel-containing methanogenic enzymes: methyl reductase and F420-reducing hydrogenase (1987)

Methanogens catalyze the hydrogen-dependent eight-electron reduction of carbon dioxide to methane. Two of the key catalysts in the eight-electron reduction pathway are the nickel-containing enzymes F420-reducing hydrogenase and methyl reductase. In the present study, the structures of these archaebacterial enzymes from Methanobacterium thermoautotrophicum delta H have been determined by electron microscopy. By negative stain techniques, F420 hydrogenase was found to be a ring structure with a diameter of 15.7 nm and an inner channel 4 nm in diameter. Shadow-casting experiments demonstrated that the rings were 8.5 nm deep, indicating a holoenzyme molecular weight of 8.0 X 10(5). Methyl reductase appeared to be an oligomeric complex of dimensions 8.5 by 9 by 11 nm, with a central stain-penetrating region. The morphology and known subunit composition suggest a model in which the subunits are arranged as an eclipsed pair of open trimers. Methyl reductase was also found in the form of larger aggregates and in paracrystalline arrays derived from highly concentrated solutions. The extremely large size of F420 hydrogenase and the methyl reductase supramolecular assemblies may have relevance in vivo in the construction of multiprotein arrays that function in methane biogenesis.
Synthesis, Characterization, and Growth Mechanism of n-Type CuInS2 Colloidal Particles (2009)

We report on the growth of CuInS2 n-type semiconductive particles, prepared using a modified Czekelius’s colloidal method, as well as their chemical and electrochemical properties. Solid state Raman spectroscopy revealed two crystalline phases: chalcopyrite and the so-called copper−gold phase. Increasing the annealing temperature of the particles favors the formation of the chalcopyrite phase. As shown by XPS, EDX, and ICP-AES, an excess of indium was obtained, which was greater at the surface (CuIn1.45S1.9 at 450 °C) than in the bulk (CuIn1.04S1.74 at 450 °C). UV−visible measurements showed that the n-type CuInS2 possesses a direct bandgap energy of 1.45 eV. Two organic redox couples in nonaqueous media were used to perform the capacitance measurements carried out by EIS on a CuInS2 film: 5-mercapto-1-methyltetrazolate (T−)/di-5-(1-methyltetrazole) disulfide (T2) and 5-trifluoromethyl-2-mercapto-1,3,4-thiadiazolate (G−)/5,5′-bis(2-trifluoromethyl-1,3,4-thiadiazole) disulfide (G2). Fermi levels of −3.95 eV and −3.64 eV and majority charge carrier densities of 4.1 × 1018 and 1.8 × 1018 cm−3 were determined, respectively, using these redox couples. On the basis of the CuInS2/electrolyte energy level diagrams, the G−/G2 redox couple is expected to lead to a more efficient device (greater photocurrent and photovoltage). In situ Raman spectroscopy measurements showed that the reactivity of copper with hexamethyldisilathiane is faster than with indium. This explains the excess of indium at the surface of the CuInS2 particles, as well as its n-type semiconductivity.
Study on Compressibility Control of Hyperelastic Material for Homogenization Method Using Mixed Finite Element Analysis (2009)

It is well known that the compressibility or incompressibility of biological tissue stems from its microscopic structure, which is generally composed of material with varied compressibility, including incompressibility. This paper proposes a framework for a homogenization method in which the compressibility/incompressibility of the macrostructure properly reflects that of the microstructure. The formulation is based on the mixed variational principle with a perturbed Lagrange-multiplier. It is shown that the rate of volumetric change of the macrostructure can be controlled through the homogenization procedure by introducing the constraint on the microstructure only. A couple of numerical examples are given to demonstrate the validity of the proposed method. By comparing the numerical results with theoretical solutions, the method is also confirmed to be free from locking.
Antifibrinolytic therapy for preventing oral bleeding in patients with a hemophilia or Von Willebrand disease undergoing oral or dental procedures (2014)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: Primarily, we aim to assess the efficacy of antifibrinolytic agents to prevent bleeding complications in people with hemophilia or VWD undergoing oral surgery. Secondary objectives are to assess if antifibrinolytic agents can replace or reduce the need for clotting factor concentrate therapy or desmopressin in people with hemophilia or VWD and further establish the effects of these agents on bleeding in oral surgery for each of these patient populations.
Smart Drug Delivery from Electrospun Fibers through Electroresponsive Polymeric Nanoparticles (2018)

Electrospun poly(ε-caprolactone) (PCL) microfibers loaded with poly(3,4-ethylenedioxythiophene) nanoparticles (PEDOT NPs) and curcumin with diameter of 3.9 ± 0.7 μm have been prepared and subsequently characterized using different spectroscopic techniques, scanning electron microscopy, and atomic force microscopy. PEDOT NPs, which are mainly located inside the PCL microfibers, exhibit a diameter of 99 ± 21 nm. PEDOT- and curcumin-containing PCL microfibers behave as extracellular cell matrices, facilitating cell spreading and enhancing cell proliferation because of their heterogeneity and roughness. The release of curcumin from the PCL microfibers by simple diffusion is very slow, external electric stimuli being required to boost and regulate the curcumin delivery process. PEDOT NPs behave as electroactuators upon application of well-defined potential pulses, increasing their diameter by about 17% and migrating from inside the PCL matrix to the surface of the microfibers. This electromechanical actuation mechanism affects the structure of the PCL matrix, promoting the release of curcumin that increases with the number of pulses. Overall, PCL fibers loaded with electroresponsive PEDOT NPs represent a promising and valuable drug delivery system that can be regulated by using pulsatile electrical stimulation.
Survivability quantification of communication services (2008)

Our society is heavily dependent on a wide variety of communication services. These services must be available even when undesirable events like sabotage, natural disasters, or network failures happen. The network survivability as defined by the ANSI T1A1.2 committee is the transient performance from the instant an undesirable event occurs until steady state with an acceptable performance level is attained. In this paper we assess the survivability of a network with virtual connections exposed to link or node failures. We have developed both simulation and analytic models to cross validate our assumptions. In order to avoid state space explosion while addressing large networks we decompose our models first in space by studying the nodes independently and then in time by decoupling our analytic performance and recovery models which gives us a closed form solution. The modeling approaches are applied to two network examples. The results show very good correspondence between the transient loss and delay performance in our simulations and in the analytic approximations.
Synthesis of a Human Urate Transporter-1 Inhibitor, an Arginine Vasopressin Antagonist, and a 17β-Hydroxysteroid Dehydrogenase Type-3 Inhibitor, Using Ring-Expansion of Cyclic Ketoximes with DIBALH (2014)

Synthesis of three clinical candidates for medicines, a human urate transporter-1 inhibitor, an arginine vasopressin antagonist, and a 17β-hydroxysteroid dehydrogenase type-3 inhibitor, is described. These compounds were synthesized via construction of their 3,4-dihydro-2H-benzo[b][1,4]oxazine, dibenzodiazepine, and dibenzazocine skeletons, respectively, using the reductive ring-expansion reaction of the corresponding bicyclic or tricyclic oximes with diisobutylaluminum hydride.
Research progress about the effect and prevention of blue light on eyes (2018)

In recent years, people have become increasingly attentive to light pollution influences on their eyes. In the visible spectrum, short-wave blue light with wavelength between 415 nm and 455 nm is closely related to eye light damage. This high energy blue light passes through the cornea and lens to the retina causing diseases such as dry eye, cataract, age-related macular degeneration, even stimulating the brain, inhibiting melatonin secretion, and enhancing adrenocortical hormone production, which will destroy the hormonal balance and directly affect sleep quality. Therefore, the effect of Blu-rays on ocular is becoming an important concern for the future. We describe blue light's effects on eye tissues, summarize the research on eye injury and its physical prevention and medical treatment.
Evaluation of tear samples for Herpes Simplex Virus 1 (HSV) detection in suspected cases of viral keratitis using PCR assay and conventional laboratory diagnostic tools (2010)

Corneal scrapings yielded a significantly better HSV positivity than tears in both the PCR assay (p<0.0005) and immunofluorescence assay. PCR was much more sensitive than immunofluorescence and virus isolation. However, tears should be tested for definitive laboratory diagnosis of HSV infection whenever corneal scraping collection is not possible.
Impaired Long-Chain Fatty Acid Utilization by Cardiac Myocytes Isolated From Mice Lacking the Heart-Type Fatty Acid Binding Protein Gene (1999)

Heart-type fatty acid binding protein (H-FABP), abundantly expressed in cardiac myocytes, has been postulated to facilitate the cardiac uptake of long-chain fatty acids (LCFAs) and to promote their intracellular trafficking to sites of metabolic conversion. Mice with a disrupted H-FABP gene were recently shown to have elevated plasma LCFA levels, decreased cardiac deposition of a LCFA analogue, and increased cardiac deoxyglucose uptake, which qualitatively establishes a requirement for H-FABP in cardiac LCFA utilization. To study the underlying defect, we developed a method to isolate intact, electrically stimulatable cardiac myocytes from adult mice and then studied substrate utilization under defined conditions in quiescent and in contracting cells from wild-type and H-FABP(-/-) mice. Our results demonstrate that in resting and in contracting myocytes from H-FABP(-/-) mice, both uptake and oxidation of palmitate are markedly reduced (between -45% and -65%), whereas cellular octanoate uptake, and the capacities of heart homogenates for palmitate oxidation and for octanoate oxidation, and the cardiac levels of mRNAs encoding sarcolemmal FA transporters remain unaltered. In contrast, in resting H-FABP(-/-) cardiac myocytes, glucose oxidation is increased (+80%) to a level that would require electrical stimulation in wild-type cells. These findings provide a physiological demonstration of a crucial role of H-FABP in uptake and oxidation of LCFAs in cardiac muscle cells and indicate that in H-FABP(-/-) mice the diminished contribution of LCFAs to cardiac energy production is, at least in part, compensated for by an increase in glucose oxidation.
Trochlear dysplasia: imaging and treatment options (2018)

Recurrent patellar dislocation is a disabling condition, which can lead to articular cartilage injuries, osteochondral fractures, recurrent instability, pain, decreased activity and patellofemoral osteoarthritis. Trochlear dysplasia represents an important component of patellar dislocation.Imaging provides an objective basis for the morphological abnormalities and thus allows determination of the surgical strategy according to the concept of 'à la carte' surgery.The main surgical techniques of trochleoplasty are the sulcus deepening trochleoplasty, the 'Bereiter' trochleoplasty and the recession trochleoplasty.At mid-term, all techniques have shown a postoperative improvement in clinical scores, with a low rate of recurrence of dislocation and a possible return to sport. But these techniques do not halt the progression of patellofemoral arthritis. Cite this article: <i>EFORT Open Rev</i> 2018;3 DOI: 10.1302/2058-5241.3.170058.
Synthesis of an Isoglutathione Derivative by Proteases and Its α→γ Transpeptidation (1981)

Journal Article Synthesis of an Isoglutathione Derivative by Proteases and Its α→γ Transpeptidation Get access Mineyuki Hayashi, Mineyuki Hayashi Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., 3–6–6 Asahicho, Machida, Tokyo 194, Japan Search for other works by this author on: Oxford Academic Google Scholar Masanaru Misawa, Masanaru Misawa Tokyo Research Laboratory, Kyowa Hakko Kogyo Co., 3–6–6 Asahicho, Machida, Tokyo 194, Japan Search for other works by this author on: Oxford Academic Google Scholar Yoshikazu Isowa Yoshikazu Isowa Sagami Chemical Research Center, Sagamihara, Kanagawa 229, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 45, Issue 12, 1 December 1981, Pages 2723–2729, https://doi.org/10.1080/00021369.1981.10864953 Published: 01 December 1981 Article history Received: 17 December 1980 Published: 01 December 1981
Reviews in Computational Chemistry. Volume 16 Edited by Kenny B. Lipkowitz and Donald B. Boyd (Indiana UniversityPurdue University). Wiley-VCH:  New York. 2000. xxviii + 342 pp. $135.00. ISBN 0-471-38667-7. (2001)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewReviews in Computational Chemistry. Volume 16 Edited by Kenny B. Lipkowitz and Donald B. Boyd (Indiana UniversityPurdue University). Wiley-VCH: New York. 2000. xxviii + 342 pp. $135.00. ISBN 0-471-38667-7.Yvonne C. MartinView Author Information Abbott LaboratoriesCite this: J. Am. Chem. Soc. 2001, 123, 35, 8648Publication Date (Web):June 30, 2001Publication History Published online30 June 2001Published inissue 1 September 2001https://pubs.acs.org/doi/10.1021/ja015226whttps://doi.org/10.1021/ja015226wbook-reviewACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views84Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ligands,Materials,Molecular mechanics,Molecular modeling,Neural networks Get e-Alerts
Reproducibility and Validity of a Self-Administered Physical Activity Questionnaire (1994)

The simple, short questionnaires on activity and inactivity used in the Nurses' Health Study II are reasonably valid measures for epidemiological research.
Molecular characterization reveals subclasses of 1q gain in intermediate-risk Wilms tumors (2022)

Summary Chromosomal alterations have recurrently been identified in Wilms tumors (WTs) and some are associated with poor prognosis. Gain of 1q (1q+) is of special interest given its high prevalence and is currently actively studied for its prognostic value. However, the underlying mutational mechanisms and functional effects remain unknown. For 30 primary WTs, we integrated somatic SNVs, CNs and SVs with expression data and distinguished four clusters characterized by affected biological processes: muscle differentiation, immune system, kidney development and proliferation. We identified 1q+ in eight tumors that differ in mutational mechanisms, subsequent rearrangements and genomic contexts. 1q+ tumors were present in all four expression clusters and individual tumors overexpress different genes on 1q. Through integrating CNs, SVs and gene expression, we identified subgroups of 1q+ tumors reflecting differences in the functional effect of 1q gain, indicating that expression data is likely needed for further risk stratification of 1q+ WTs.
A systematic review of dermal fillers for age‐related lines and wrinkles (2010)

The treatment of age-related lines and wrinkles with permanent and semi-permanent dermal fillers is more efficacious compared with temporary fillers in those studies that compared them. Case series evidence suggests that these fillers achieve their objective, which is to decrease the visible effects of age-related changes. These fillers appear at least as safe as temporary fillers in the short term in those studies that compared them. Long-term safety could not be determined.
Channels of Communication to Farmers in Technological Change (1969)

﻿in Technological Change N S Shetty This study of sample farmers in two Mysore villages shows that institutional agencies are more important at the awareness and acquaintance stage of adoption among innovators and early adopters. These farmers, who constitute only a small proportion of total farmers, are favoured by a number of socioeconomic factors.
Mechanical Properties of End-Linked PEG/PDMS Hydrogels (2012)

Poly(ethylene glycol) (PEG)/polydimethylsiloxane (PDMS) hydrogels were synthesized by cross-linking norbornene end-functionalized polymers with a tetrafunctional thiol using thiol–norbornene chemistry. The swelling capacity and mechanical properties, including the Young’s modulus (E) and fracture toughness (Gc), of the hydrogels were characterized and quantified as a function of the volume fractions of PEG and PDMS. E and Gc increased simultaneously with the volume fraction of PDMS. The moduli of the hydrogels were quantitatively described and predicted as a function of the volume fraction ratio of PEG to PDMS using the Voigt and Reuss models. The fracture toughness was well described by the Lake–Thomas theory at low volume fractions of PDMS. As the volume fraction of PDMS increased, PDMS not only controlled the swelling capacity of the hydrogels but also contributed to hydrogel toughness.
Laminin receptor specific therapeutic gold nanoparticles ( 198 AuNP-EGCg) show efficacy in treating prostate cancer (2012)

Systemic delivery of therapeutic agents to solid tumors is hindered by vascular and interstitial barriers. We hypothesized that prostate tumor specific epigallocatechin-gallate (EGCg) functionalized radioactive gold nanoparticles, when delivered intratumorally (IT), would circumvent transport barriers, resulting in targeted delivery of therapeutic payloads. The results described herein support our hypothesis. We report the development of inherently therapeutic gold nanoparticles derived from the Au-198 isotope; the range of the (198)Au β-particle (approximately 11 mm in tissue or approximately 1100 cell diameters) is sufficiently long to provide cross-fire effects of a radiation dose delivered to cells within the prostate gland and short enough to minimize the radiation dose to critical tissues near the periphery of the capsule. The formulation of biocompatible (198)AuNPs utilizes the redox chemistry of prostate tumor specific phytochemical EGCg as it converts gold salt into gold nanoparticles and also selectively binds with excellent affinity to Laminin67R receptors, which are over expressed in prostate tumor cells. Pharmacokinetic studies in PC-3 xenograft SCID mice showed approximately 72% retention of (198)AuNP-EGCg in tumors 24 h after intratumoral administration. Therapeutic studies showed 80% reduction of tumor volumes after 28 d demonstrating significant inhibition of tumor growth compared to controls. This innovative nanotechnological approach serves as a basis for designing biocompatible target specific antineoplastic agents. This novel intratumorally injectable (198)AuNP-EGCg nanotherapeutic agent may provide significant advances in oncology for use as an effective treatment for prostate and other solid tumors.
Antimicrobial Resistance and Serotypes of Nasopharyngeal Strains of Streptococcus pneumoniae in Brazilian Adolescents (2006)

The aim of this study was to describe the frequency of antimicrobial-resistance and serotypes of nasopharyngeal pneumococcal isolates from adolescents. Clinical data and nasopharyngeal specimens for culture were collected from 1,013 adolescents as a part of a population-based study. A total of 83 isolates of Streptococcus pneumoniae were identified (8.2%). Seventy-four of the 83 isolates were serotyped. The median age of the 83 adolescents colonized by pneumococci was 14 years (mean 14 +/- 2.2 yrs); 55.4% were males. Intermediate resistance to penicillin was detected in 7.2% (6/83). No strain showed high resistance to penicillin. All isolates were susceptible to clindamycin, chloramphenicol, rifampin, and vancomycin; 37.3%, 18.1%, and 4.8% were resistant to trimethoprim-sulfamethoxazole, tetracycline, and erythromycin, respectively. The most frequent serotypes (5-10% of strains each) were 6B, 6A, 23F, and 18C among 28 serotypes/serogroups identified; 18.9% of the strains were nontypeable (NT). Intermediate resistance to penicillin was detected in serotypes 6B, 14, and NT. The rate of resistance to penicillin of nasopharyngeal isolates is low considering data from other studies about invasive strains recovered from children in Brazil. Serotype patterns are similar, except for type 14, which was unusually infrequent.
Total Synthesis of the Originally Assigned Structure of Vannusal B (2008)

Die Wahrheit ist da draußen: Die Suche nach der ursprünglich zugeordneten Struktur von Vannusal B (siehe Strukturformel) mithilfe der Totalsynthese konnte erfolgreich abgeschlossen werden, resultiert aber in einer neuen Frage – der nach der wahren Struktur dieses marinen Naturstoffs. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Electrical properties of silicon nitride films plasma-deposited from SiF4, N2, and H2 source gases (1985)

The electrical properties of the fluorinated silicon nitride films deposited from reactive plasma of SiF4-N2-H2 or SiF2-N2-H2 gas mixtures were investigated by changing the source SiF4 flow rate. A resistivity and breakdown strength as high as 1014–1016 Ω cm and 5–10 MV/cm, respectively, were reproducibly observed over a wide range of the N/Si ratio. The deep-trap densities and energy levels are not very dependent on the film composition. Their slight variation in the present deposition conditions can be understood by the slight variation of the spin density and the optical gap. The dielectric constant and the interface state density between silicon and silicon nitride are 4.8–6.0 and (1–5)×1012 cm−2 eV−1, respectively.