gebhart/patrepeval huggingface dataset:
One‐Step Conversion of Pyridine N‐Oxides to Tetrazolo[1,5‐a]pyridines. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Production and Characterization of a Pressure-induced Gel from Freeze-concentrated Milk (1993)

Journal Article Production and Characterization of a Pressure-induced Gel from Freeze-concentrated Milk Get access Keiko Kumeno, Keiko Kumeno Department of Food and Nutrition, Japan Women’s University, Bunkyo-ku, Tokyo 112, Japan Search for other works by this author on: Oxford Academic Google Scholar Nobuko Nakahama, Nobuko Nakahama Department of Food and Nutrition, Japan Women’s University, Bunkyo-ku, Tokyo 112, Japan Search for other works by this author on: Oxford Academic Google Scholar Kazuo Honma, Kazuo Honma Department of Food and Nutrition, Japan Women’s University, Bunkyo-ku, Tokyo 112, Japan Present address: Research Institute of QP Corporation, Fuchu-shi, Tokyo 183. Japan. Search for other works by this author on: Oxford Academic Google Scholar Takahiro Makino, Takahiro Makino Department of Food and Nutrition, Japan Women’s University, Bunkyo-ku, Tokyo 112, Japan Present address: Shizuoka Agricultural Experiment Station, Iwata-gun, Shizuoka 431-38, Japan. Search for other works by this author on: Oxford Academic Google Scholar Michiko Watanabe Michiko Watanabe Department of Food and Nutrition, Japan Women’s University, Bunkyo-ku, Tokyo 112, Japan Present address: Faculty of Education, Tokyo Gakugei University. Koganei-shi, Tokyo 184, Japan. Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 57, Issue 5, 1 January 1993, Pages 750–752, https://doi.org/10.1271/bbb.57.750 Published: 01 January 1993 Article history Received: 02 November 1992 Published: 01 January 1993
Large‐Scale, High‐density freezing of hybridomas and its application to high‐density culture (1991)

Large-scale, high-density freezing of hybridomas was studied to apply frozen cells to start high-density culture. We showed here that hybridomas can be frozen at 1.5 x 10(8) cells/mL, without decrement in viability and proliferating activity. Blood transporting bags were used for large-scale freezing to store 25 mL of cell suspension with a cell density, 1.5 x 10(8)/mL. The number of cells stored in a bag (3.0 x 10(9) cells) was enough to start a high-density culture at a 10 times higher cell density (6.0 x 10(6) cells/mL) than normal inoculation, and the cells proliferated to 10(7) cells/mL within 2 days. These results indicate that the large-scale freezing method is useful for large-scale culture of mammalian cells.
General Theory of the van der Waals Interaction: A Model-Independent Approach (1970)

We study the van der Waals interaction ${V}_{2\ensuremath{\gamma}}^{\mathrm{AB}}(R)$ arising from two-photon exchange between neutral spinless systems $A$ and $B$. By using the analytic properties of the two-photon contribution to the scattering amplitude for $A+B\ensuremath{\rightarrow}A+B$ and of the full amplitudes for $\ensuremath{\gamma}+A\ensuremath{\rightarrow}\ensuremath{\gamma}+A$ and $\ensuremath{\gamma}+B\ensuremath{\rightarrow}\ensuremath{\gamma}+B$, we show that it is possible to express ${V}_{2\ensuremath{\gamma}}^{\mathrm{AB}}(R)$ entirely in terms of measurable quantities, the elastic scattering amplitudes for photons of various frequencies $\ensuremath{\omega}$. This approach includes relativistic corrections, higher multipoles, and retardation effects from the outset and thus avoids any $\frac{v}{c}$ expansion or any direct reference to the detailed structure of the systems involved. We obtain a generalized form of the Casimir-Polder potential, which includes both electric and magnetic effects, and, correspondingly, a generalized asympotic form ${V}_{2\ensuremath{\gamma}}^{\mathrm{AB}}(r)\ensuremath{\sim}\ensuremath{-}\frac{D}{{R}^{7}}$, where $D=\frac{[23({\ensuremath{\alpha}}_{E}^{A}{\ensuremath{\alpha}}_{E}^{B}+{\ensuremath{\alpha}}_{M}^{A}{\ensuremath{\alpha}}_{M}^{B})\ensuremath{-}7({\ensuremath{\alpha}}_{E}^{A}{\ensuremath{\alpha}}_{M}^{B}+{\ensuremath{\alpha}}_{M}^{A}{\ensuremath{\alpha}}_{E}^{B})]}{4\ensuremath{\pi}}$ and the $\ensuremath{\alpha}$'s denote static polarizabilities. In addition, we show that the potential may be written as a single integral over $\ensuremath{\omega}$, involving products of the dynamical polarizabilities ${\ensuremath{\alpha}}_{X}(\ensuremath{\omega})$ evaluated at real frequencies, in contrast to the familiar integral over imaginary frequencies; for the case of interacting atoms, the domain of applicability of the various formulas is clarified, and the problem of evaluating ${V}_{2\ensuremath{\gamma}}^{\mathrm{AB}}(R)$ from present experimental information is discussed. Some simple interpolation formulas are presented, which may accurately describe ${V}_{2\ensuremath{\gamma}}^{\mathrm{AB}}(R)$ in terms of a few constants.
Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles (2015)

The therapeutic promise of small interfering RNAs (siRNAs) for specific gene silencing is dependent on the successful delivery of functional siRNAs to the cytoplasm. Their conjugation to an established delivery platform, such as gold nanoparticles, offers tremendous potential for treating diseases and advancing our understanding of cellular processes. Their success or failure is dependent on both the uptake of the nanoparticles into the cells and subsequent intracellular release of the functional siRNA. In this study, utilizing gold nanoparticle siRNA-mediated delivery against C-MYC, we aimed to determine if we could achieve knockdown in a cancer cell line with low levels of intracellular glutathione, and determine the influence, if any, of polyethylene glycol (PEG) ligand density on knockdown, with a view to determining the optimal nanoparticle design to achieve C-MYC knockdown. We demonstrate that, regardless of the PEG density, knockdown in cells with relatively low glutathione levels can be achieved, as well as the possible effect of steric hindrance of PEG on the availability of the siRNA for cleavage in the intracellular environment. Gold nanoparticle uptake was demonstrated via transmission electron microscopy and mass spectroscopy, while knockdown was determined at the protein and physiological levels (cells in S-phase) by in-cell westerns and BrdU incorporation, respectively.
Real time driver drowsiness detection using a logistic-regression-based machine learning algorithm (2016)

The number of car accidents due to driver drowsiness is very steep. An automated non-contact system that can detect driver's drowsiness early could be lifesaving. Motivated by this dire need, we propose a novel method that can detect driver's drowsiness at an early stage by computing heart rate variation using advanced logistic regression based machine learning algorithm. Our developed technique has been tested with human subjects and it can detect drowsiness in a minimum amount of time, with an accuracy above 90%.
Cloning and Characterization of Extracellular Ca 2+-Sensing Receptors from Parathyroid and Kidney (1994)

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MIF‐CD74 Signaling Protects against Endothelial Senescence in Chronic Obstructive Pulmonary Disease (2020)

RATIONALE Chronic obstructive pulmonary disease (COPD) is characterized by gradual destruction of alveolar architecture and subsequent airflow obstruction. Advancing age and significant exposure to cigarette smoke (CS) are common risk factors, yet the pathologic manifestations of COPD are heterogenous and the biologic risk factors for COPD are unclear. MIF is an important regulator of innate immunity, cellular homeostasis and survival. We previously reported that circulating MIF was lower in smokers with COPD compared with smokers without COPD. Others have confirmed these findings and correlated decreased MIF protein with greater radiologic/functional evidence of emphysema in patients. METHODS Gene expression microarray analysis was performed on lung tissue from individuals with/without COPD (n=262), and endothelial cell (Ec) CD74 expression was analyzed in single‐cell RNA‐seq (control=19, COPD=29). CD74 expression was determined by immunohistochemistry in human lung. CS extract (CSE) treated to HUVEC along with the following recombinant‐MIF (rMIF), MIF‐siRNA, neutralizing anti‐MIF monoclonal antibody (anti‐MIF mAb), MIF098 (MIF antagonist), or MIF20 (MIF agonist). U0126 (ERK inhibitor) was treated 1 hour prior to MIF20 treatment. MIF‐KO mice were treated with a control or MIF expressing lentiviral‐vector. Ec were isolated via MACS sorting. AKR/J mice were exposed to CS (4 months), and MIF20 was administered orally (3 mg/mouse) to mice every day for the final 2 months of CS exposure. Pressure‐Volume (PV) loops were measured by FlexiVent. RESULTS CD74 expression was increased in COPD patients especially in lung Ec. CSE increased p16 and p21 mRNA expression in HUVEC. This increase was attenuated by rMIF or MIF20, while augmented by anti‐MIF mAb or MIF98. CSE increased SA‐β‐gal activity and MIF20 attenuated it. The protective effect of MIF20 against CS‐induced Ec senescence was abolished by ERK signaling inhibitor. MIF‐KO mice showed an upshift of PV loop and increased Ec p21 expression, which were attenuated by restoration of MIF expression. CS induced upshift of PV loop, increased p16 and p21 expression, which were attenuated by MIF20. CONCLUSIONS The expression of CD74, the cognate receptor for MIF, was increased in COPD. Senescence was induced in Ec by CS, an important causative factor for COPD. MIF20, a novel small molecule MIF agonist, attenuated CS‐induced senescence via ERK signaling, which is known to support cell survival and proliferation. Furthermore, MIF20 prevented CS‐induced lung emphysema. These data suggest that therapeutic modulation of MIF targeting in lung Ec is feasible represents a novel strategy to protect against senescence‐induced COPD. Support or Funding Information M.S. is supported by NIH/NHLBI K08HL135402 and FAMRI YCSA 142017. P.J.L. is supported by NIH/NHLBI R01 HL138386, VAORD11858595, US Department of Defense PR150809, and FAMRI 150074.
Prevalence and Morphology of Pouch and Ileal Adenomas in Familial Adenomatous Polyposis (2005)

The risk of pouch cancer in familial adenomatous polyposis is unclear, but follow-up periods since surgery remain relatively short. Long-term endoscopic surveillance of familial adenomatous polyposis pouches is thus recommended along with evaluation of potential therapeutic options for pouch adenomas.
Biosurfactant Production By A New Pseudomonas Putida Strain (2002)

Observation of both tensio-active and emulsifying activities indicated that biosurfactants were produced by the newly isolated and promising strain Pseudomonas putida 21BN. The biosurfactants were identified as rhamnolipids, the amphiphilic surface-active glycolipids usually secreted by Pseudomonas spp. Their production was observed when the strain was grown on soluble substrates, such as glucose or on poorly soluble substrates, such as hexadecane, reaching values of 1.2 g l(-1). When grown on hexadecane as the sole carbon source the biosurfactant lowered the surface tension of the medium to 29 mN m(-1) and formed stable and compact emulsions with emulsifying activity of 69%.
A 64-Solenoid, Four-Level Fingertip Search Display for the Blind (1987)

This paper describes the design and prototype model of a nonvibrating fingertip search display device. It was designed for use in experiments to determine the importance of fingertip exploration in tactile vision substitution. An 8 ×8 array of miniature dc solenoids mounted on 5 mm centers forms a raised two-dimensional display. With the aid of an IBM PC, it translates a visual image into a contour map of raised pins similar to transitory braille. The four possible pin heights of 0, 0.33, 0.67, and 1 mm represent discrete levels of image intensity. The user controls the location and resolution of the image sent from the IBM PC to the display by moving a mouse.
Design of very small UWB monopole antenna with reconfigurable band-notch performance (2012)

In this paper, a compact reconfigurable ACS fed monopole antenna with size of 6.3×12 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> that has a capability to operate in the ultrawideband (UWB) frequency band with reconfigurable one or two notched band (the rejected bands cover the frequency bands ranging from 3.5 to 4 GHz and 5.15 to 5.825 GHz) is presented. The antenna consist of a simple rectangle patch with folded shape stub and slit as band rejecting elements. The band reject reconfigurable ability is achieved via two RF p-i-n diode switches that positioned in the rejecting elements. The proposed technique offers the solution to the problem encountered in existing reconfigurable antennas which serve only one frequency band at a time. A good agreement is found between the simulated and the measured antenna radiation properties. To the authors' knowledge, a feature of very small size of antenna with good performance is unique to this paper.
Generation of Depositional Facies Maps Using Microcomputers and Lithocrossplot Data, Minnelusa Formation, Powder River Basin: ABSTRACT (1985)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
The Influence of Fluid Menisci on Nanoparticle Dosimetry in Submerged Cells (2022)

Understanding the interaction between cells and nanoparticles (NPs) is important to understand the hazard associated with nanoparticles. This requires quantifying and interpreting dose-response relationships, and cells cultured <em>in vitro</em> and exposed to particle dispersions mainly rely on mathematical models that estimate the received nanoparticle dose. Yet, none of these models consider that aqueous cell-culture media wet the inner surface of hydrophilic open wells, which results in a curved fluid-air interface called meniscus. Here we address in detail the impact of the meniscus on nanoparticle dosimetry. We present experiments, build an advanced mathematical model, and find that the presence of meniscus may bring about systematic errors that must be considered to advance reproducibility and harmonization. Finally, we also propose simple practical solutions to this problem, such as covering the air-liquid interface with a permeable lid or soft rocking of the cell culture well plate.
Studies on the Synthesis of 13-Methyltetrahydroprotoberberine Derivative (1978)

o b e r b e r i n e ( VIII ) .
Conformationally readdressed CCK‐B/δ‐opioid pepitide ligands (1995)

The sequence of a cholecystokinin (CCK) related peptide was modified to obtain analogues, which interact selectively either with CCK-B, or with delta-opioid receptors. Two kinds of peptides were designed, namely, the cyclic peptides of the H-Tyr-cyclo (D-Pen-Gly-Trp-L/D-3-transmercaptoproline)-Asp-Phe-NH2 sequence (compounds 1a and 1b, respectively), and the linear peptides of the H-Tyr-D-Val-Gly-Trp-L/D-3-trans-methylmercaptoproline-Asp-Phe- NH2 sequence (compounds 2a and 2b, respectively). The only difference between the chemical structures of the linear analogues compared to the cyclic ones is that one covalent bond has been eliminated and a sulfur atom is replaced by a methyl group. Molecular modeling showed that, among low-energy conformers of cyclic compounds 1, there are three-dimensional structures compatible to the model for delta-receptor-bound conformer, suggested earlier [G. V. Nikiforovich, V.J. Hruby, O. Prakash, and C.A. Gehrig (1991) Biopolymers, vol. 31, pp. 941-955]. Results of binding assays fully supported the rationale for the design of compounds 1 and 2. The cyclic analogue 1a has Ki values of 4.5 and > 5000 nM at delta- and mu-opioid receptors, respectively; and IC50 values of 1.6 and > 10,000 nM for CCK-A and CCK-B receptors, respectively. The results of this study demonstrate a possibility to redirect a peptide sequence that interacts with one type of receptors (CCK-B receptors) toward interaction with another type (delta-opioid receptors) belonging to a different physiological system. This redirection could be performed by changing the conformational properties of the peptide with very minimal changes in its chemical structure.
Sliverware : a framework for developing collaborative applications (2017)

Despite computers' widespread use for personal applications, very few programming frameworks exist for creating synchronous collaborative applications. Existing research in CSCW (computer supported cooperative work), specifically approaches that attempt to make current application implementations collaboration-aware, are difficult to implement for two reasons: the systems are focused too narrowly (e.g., on Internet-only applications), or the systems are simply too complicated to be adopted (e.g., they are hard to set up and adapt to concrete applications). Enabling real-time collaboration demands lightweight, modular middleware—sliverware—that enables the fine-grained interactions required by collaborative applications. In this paper, we introduce sliverware and give a specific example in the guise of a distributed keyboard that multiplexes input from several users into a single stream that each user receives just like input from a normal keyboard. The result is simple, real-time collaboration based on a shared, distributed view of data that enables rapid development of highly coupled coordinating applications.
Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer’s Disease (2021)

Neuroinflammation is a common feature in Alzheimer's (AD) and Parkinson's (PD) disease. In the last few decades, a testable hypothesis was proposed that protein-unfolding events might occur due to neuroinflammatory cascades involving alterations in the crosstalk between glial cells and neurons. Here, we tried to clarify the pattern of two of the most promising biomarkers of neuroinflammation in cerebrospinal fluid (CSF) in AD and PD. This study included cognitively unimpaired elderly patients, patients with mild cognitive impairment, patients with AD dementia, and patients with PD. CSF samples were analyzed for YKL-40 and C-reactive protein (CRP). We found that CSF YKL-40 levels were significantly increased only in dementia stages of AD. Additionally, increased YKL-40 levels were found in the cerebral orbitofrontal cortex from AD patients in agreement with augmented astrogliosis. Our study confirms that these biomarkers of neuroinflammation are differently detected in CSF from AD and PD patients.
Antibacterial actions of fatty acids and monoglycerides againstHelicobacter pylori (2003)

The bactericidal potencies of saturated and unsaturated fatty acids (FAs) and monoglycerides (MGs) against Helicobacter pylori were determined following short incubations with freshly harvested cells over a range of pHs. FAs and their derivatives with an equivalent-carbon number of 12 were the most potent: lauric acid had a minimum bactericidal concentration (MBC) at pH 7.4 of 1 mM, myristoleic and linolenic acid were the most potent unsaturated FAs (MBCs of 0.5 mM, pH 7.4), and monolaurin was the most potent MG (MBC 0.5 mM). Potencies of saturated FAs were increased sharply by lowering pH, and a decrease of only 0.5 pH units can cause a change from non-lethal to lethal conditions. Conversely, the bactericidal action of monolaurin was not pH-dependent. The bactericidal potencies of unsaturated FAs increased with degree of unsaturation. When more than one FA or FA plus MGs were present, their combined action was additive. Urea and endogenous urease did not protect H. pylori from the bactericidal action of FAs. These results suggest that H. pylori present in the stomach contents (but not necessarily within the mucus barrier) should be rapidly killed by the millimolar concentrations of FAs and MGs that are produced by pre-intestinal lipase(s) acting on suitable triglycerides such as milk fat.
Inflammatory Fabry Cardiomyopathy Demonstrated Using Simultaneous [18F]-FDG PET-CMR (2023)

Using hybridized [<sup>18</sup>F]-fluorodeoxyglucose positron emission tomography with cardiac magnetic resonance, we identify active myocardial inflammation and demonstrate its relationship with late gadolinium enhancement, in Fabry disease. We demonstrate that late gadolinium enhancement represents, at least in part, active myocardial inflammation and identify an early inflammatory phenotype that may represent a therapeutic window before irreversible tissue injury and adaptation occur. (<b>Level of Difficulty: Intermediate.</b>).
Accurate magnetic field transducers based on silicon hall sensors (1999)

These Ecole polytechnique federale de Lausanne EPFL, n° 1985 (1999)Faculte des sciences et techniques de l'ingenieurJury: Hannes Bleuler, Marc Ilegems, Jan Korvink, Simon Middelhoek Public defense: 1999-5-26 Reference doi:10.5075/epfl-thesis-1985Print copy in library catalog Record created on 2005-03-16, modified on 2016-08-08
Underwater 3D modelling and photosynthetic life detection (2012)

Automatic detection of photosynthetic life underwater when combined with photorealistic 3D models of observed sites offers a powerful tool for scientific investigations. This paper describes underwater Scene Modeler (uSM) and presents results of experiments in mapping and modelling microbialites colonies conducted as part of the Pavilion Lake Research Project (PLRP). uSM can be also used for monitoring health of marine plants, such as coral and algae, and inspection of underwater structures.
Visible-Light-Induced Specific Desulfurization of Cysteinyl Peptide and Glycopeptide in Aqueous Solution (2016)

Visible-light-induced specific desulfurization of cysteinyl peptides has been explored. The photocatalytic desulfurization catalyzed by Ru(bpy)3(2+) can proceed efficiently at room temperature in aqueous solution or in binary mixtures of aqueous/organic solvent and be compatible with the presence of residues of amino acids, carbohydrates, and various sulfur-containing functional groups. This approach was successfully applied to synthesize linear and cyclic peptides through the ligation-desulfurization protocol.