gebhart/patrepeval huggingface dataset:
A Novel Localization of the G-Protein-Coupled CysLT1 Receptor in the Nucleus of Colorectal Adenocarcinoma Cells (2005)

Searching for a link between inflammation and colon cancer, we have found that the inflammatory mediator leukotriene D(4) (LTD(4)), via its receptor CysLT(1), induces cyclooxygenase-2 expression, survival, and proliferation in intestinal epithelial cells. In conjunction with our previous observation that CysLT(1) receptor expression is increased in colorectal adenocarcinomas, we here found an increased nuclear localization of the CysLT(1) receptor in colorectal adenocarcinomas. This novel discovery of CysLT(1) receptors in the nucleus was further analyzed. It was found to be located in the outer nuclear membrane in colon cancer cells and in the nontransformed epithelial cell line Int 407 cells by Western blot and electron microscopy. Cancer cells displayed higher amounts of the nuclear CysLT(1) receptor, but prolonged LTD(4) exposure induced its nuclear translocation in nontransformed cells. Truncation of a nuclear localization sequence abrogated this translocation as well as the LTD(4)-induced proliferative response. In accordance, nuclear CysLT(1) receptors exhibited proliferative extracellular signal-regulated kinase 1/2 signaling. The significance of these experimental findings is supported by the observed correlation between the proliferative marker Ki-67 and nuclear CysLT(1) receptor localization in colorectal adenocarcinomas. The present findings indicate that LTD(4) cannot only be synthesized but also signal proliferation through nuclear CysLT(1) receptors, stressing the importance of leukotrienes in inflammation-induced colon carcinogenesis.
Utopia documents: linking scholarly literature with research data (2010)

http://getutopia.com.
A freestanding NiSxporous film as a binder-free electrode for Mg-ion batteries (2017)

An ultrathin, freestanding NiS<sub>x</sub> nanoporous thin-film was developed by facile electrochemical deposition, etching, anodization and chemical vapor treatments. The NiS<sub>x</sub> nanoporous thin-film shows excellent reversible insertion/extraction of Mg ions and long-term cycling performance, which is an ideal energy storage device for small/micro-size electronic and medical devices.
A Palladium/Porous-Glass Composite Membrane for Hydrogen Separation (1988)

Abstract Palladium was deposited on a porous-glass tube using a technique of electroless-plating. This composite membrane exhibited a remarkable permeability to hydrogen. Moreover, hydrogen was selectively separated from H2–N2 and H2–CO gas mixtures through the composite membrane.
The Significance of Functional Renal Obstruction in Predicting Pathologic Stage of Upper Tract Urothelial Carcinoma (2014)

This study suggests that renal obstruction by radiographic analysis does not always predict advanced stage. In addition, there is a trend toward advanced stage when a patient has radiographic evidence of ipsilateral renal dysfunction and a ureteral tumor.
Relaxing Consensus in Distributed Factored Evolutionary Algorithms (2016)

Factored Evolutionary Algorithms (FEA) have proven to be fast and efficient optimization methods, often outperforming established methods using single populations. One restriction to FEA is that it requires a central communication point between all of the factors, making FEA difficult to use in completely distributed settings. The Distributed Factored Evolutionary Algorithm (DFEA) relaxes this requirement on central communication by having neighboring factors communicate directly with one another. While DFEA has been effective at finding good solutions, there is often an increase in computational complexity due to the communication between factors. In previous work on DFEA, the authors required the algorithm reach full consensus between factors during communication. In this paper, we demonstrate that even without full consensus, the performance of DFEA was not statistically different on problems with low epistasis. Additionally, we found that there is a relationship between the convergence of consensus between factors and the convergence of fitness of DFEA.
Adhesively Bonded Blanks for Local Reinforcements in Body-in-White Manufacturing (2015)

Adhesively bonded blanks are manufactured using a method for combined forming and bonding of locally reinforced parts for body-in-white in the automotive and truck industry. The method allows lightweight constructions with steel sheets by generally reducing the thickness of body parts and compensates stiffness as well as strength by steel grades of higher yield points and locally applied reinforcement sheets where necessary. Applying adhesive bonding in the body-in-white shops implies certain boundary conditions, such as bonding on oiled surfaces and curing at cataphoretic burn-in after coating. Adhesive bonding, with the forming process being employed between, was successfully applied with film adhesives based on different polymer families and works the best in two steps, as the formation of already bonded and cured parts causes much damage to the bond lines. Due to the early softening stage in the electro coat (EC) burn-in oven, the adhesive in most cases needs the assistance of an additional fixation technique to avoid negative results of unwanted spring-back behaviour (especially with reinforcement sheets with higher yield points). Efficient auxiliary techniques for fixation are usually not based on adhesive technology because of a process-related short time frame. Three different fixation techniques additionally to the adhesive bonding of the reinforcement sheets were investigated in a research project. This paper discusses options and results on the complex interaction between forming and adhesive bonding.
Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) (2016)

Ebola virus infection can cause severe hemorrhagic fever with a high mortality in humans. The outbreaks of Ebola viruses in 2014 represented the most serious Ebola epidemics in history and greatly threatened public health worldwide. The development of additional effective anti-Ebola therapeutic agents is therefore quite urgent. In this study, via high throughput screening of Food and Drug Administration-approved drugs, we identified that teicoplanin, a glycopeptide antibiotic, potently prevents the entry of Ebola envelope pseudotyped viruses into the cytoplasm. Furthermore, teicoplanin also has an inhibitory effect on transcription- and replication-competent virus-like particles, with an IC50 as low as 330 nm Comparative analysis further demonstrated that teicoplanin is able to block the entry of Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS) envelope pseudotyped viruses as well. Teicoplanin derivatives such as dalbavancin, oritavancin, and telavancin can also inhibit the entry of Ebola, MERS, and SARS viruses. Mechanistic studies showed that teicoplanin blocks Ebola virus entry by specifically inhibiting the activity of cathepsin L, opening a novel avenue for the development of additional glycopeptides as potential inhibitors of cathepsin L-dependent viruses. Notably, given that teicoplanin has routinely been used in the clinic with low toxicity, our work provides a promising prospect for the prophylaxis and treatment of Ebola, MERS, and SARS virus infection.
Near-Field Modeling of Particle-Particle Interactions (2008)

We demonstrate an extension of the coupled dipole approximation to model particle-particle or probe-object interactions in optical near fields. These interactions determine the properties of both optical forces and scattered intensities.
Three-dimensional spiral CT angiography of the abdomen: initial clinical experience. (1993)

Spiral computed tomography (CT) is a new technology that couples continuous tube rotation with continuous table feed. This allows compilation of a data set that has continuous anatomic information without the establishment of arbitrary boundaries at section interfaces as in conventional CT. The unique method of data collection of the spiral scanner has been combined with a dynamic intravenous contrast material bolus to image abdominal vasculature, specifically, the aorta, renal arteries, and splanchnic circulation. Through various techniques of image processing, including surface renderings and maximum-intensity projections, it is possible to obtain excellent anatomic detail of the aorta and its major branches. The authors applied this technique in 15 patients and reliably saw third-order aortic branches as well as third-order splenic-portal venous anatomic detail with remarkable clarity. Pathologic conditions detected include stenotic renal arteries, abdominal aortic dissection, abdominal aortic aneurysm, and celiac bypass graft occlusion.
Phytochemical Variability of Essential Oils of Two Balkan Endemic Species: Satureja pilosa Velen. and S. kitaibelii Wierzb. ex Heuff. (Lamiaceae) (2022)

<i>Satureja pilosa</i> and <i>S. kitaibelii</i> (Lamiaceae) are Balkan endemic plant species, and the composition of their essential oil (EO) is highly variable. The aim of the present study was to establish: (1) the EO variability in two populations of <i>S. pilosa</i> (the intrapopulation), and (2) the EO variation in <i>S. kitaibelii</i> between nine populations (interpopulation) from Bulgaria and two from Serbia. The EOs of two <i>Satureja</i> species were obtained from aboveground plant parts by hydrodistillation and were analyzed by GC/MS/FID. Overall, the EO yield on the intrapopulation level of <i>S. pilosa</i> varied from 0.54% to 2.15%, while the EO of <i>S. kitaibelii</i> varied from 0.04% to 0.43% (interpopulation). The EO of <i>S. pilosa</i> was found to contain thymol and carvacrol as the main constituents, with other major constituents being <i>p</i>-cymene and <i>γ</i>-terpinene. <i>S. pilosa</i> samples in both studied populations formed six chemical groups. The major constituents (<i>p</i>-cymene, terpinen-4-ol, bornyl acetate, <i>γ</i>-muurolene, <i>endo</i>-borneol, <i>cis</i>-<i>β</i>-ocimene, <i>trans</i>-<i>β</i>-ocimene, carvacrol, <i>α</i>-pinene, thymoquinone, geranial, geranyl acetate, spathulenol, and caryophyllene oxide) of <i>S. kitaibelii</i> EO were considered for grouping the populations into ten chemotypes. The present study is the first report on the interpopulation diversity of <i>S. kitaibelii</i> EOs in Bulgaria. It demonstrated variability of the EOs between and within the populations of <i>S. kitaibelii</i> from Bulgaria. This study identified promising genetic material that could be further propagated and developed into cultivars for commercial production of <i>S. kitaibelii</i> and <i>S. pilosa</i>, thereby reducing the impact of collection on wild populations.
Interleukin-1 Release by Alveolar Macrophages in Asthmatic Patients and Healthy Subjects (1990)

A thymocyte proliferative response assay was used to compare spontaneous and lipopolysaccharide (LPS)-induced interleukin-1 (IL-1) release by alveolar macrophage (AM) in asthmatic patients and normal subjects. Twelve asthmatic patients and seven nonsmoking healthy subjects underwent a bronchoalveolar lavage (BAL). All asthmatic patients had a reversible airway obstruction and 7/12 were allergic. BAL AM were separated by adherence on tissue culture plates in medium RPMI-1640 supplemented with antibiotics and fetal calf serum, and were incubated with or without 10 micrograms/ml LPS for 20 h. Free-cell supernatants were tested by C3H/HeJ mice thymocyte proliferative assay. Unstimulated AM supernatant IL-1 activity was significantly higher in asthmatic patients (mean +/- SEM: 47.8 +/- 11.9 units/10(6) AM) in comparison with healthy subjects (4.8 +/- 2.3 units/10(6) AM; p less than 0.05, Mann-Whitney U test) but did not significantly differ between allergic (42.2 +/- 15.5 units/10(6) AM) and intrinsic asthmatic patients (55.8 +/- 20.7 units/10(6) AM). For healthy subjects, IL-1 activity was significantly higher in LPS-stimulated AM supernatants (85 +/- 20 units/10(6) AM, p less than 0.05; Mann-Whitney U test) in comparison with unstimulated ones; for asthmatic patients, unstimulated and LPS-stimulated AM supernatant IL-1 activity did not significantly differ. This finding is in accordance with previous work suggesting that AM from asthmatic patients have a weak suppressive activity upon lymphocyte proliferation and emphasize the enhanced AM releasability in asthma.
Biosynthese der Verrucarine und Roridine. Teil 2 Der Einbau von Acetat in die cis,trans‐Muconsäure und von Mevalonat in die Roridinsäure Verrucarine und Roridine, 28. Mitteilung [2] (1975)

Abstract Incorporation experiments using sodium [1‐ 14 C]‐acetate and sodium [2‐ 14 C]‐ and [2‐ 14 C,2‐ 3 H 2 ]‐mevalonate and degradations of the verrucarin A ( 1 ) and roridin A ( 2 ) so produced demonstrate that cis,trans ‐muconic acid ( 3 ) is formed from 3 acetate units. The cis,trans ‐muconic acid and the C 2 ‐side‐chain structural elements of roridinic acid ( 6 ) are built up from 4 acetate units; the cis ‐oricntcd C(11)‐carboxyl group of 6 originates from C(1) of acctic acid. The structural moiety of roridinic acid ( 6 ) corresponding to verrucarinic, acid ( 7 ) originates from mevalonate, as does 7 . A new degradation scheme was devised for roridinic acid ( 6 ); the oxime 23 of its 13 dehydro‐detrahydro derivative 21 underwent cleavage with SOCl 2 and subsequent hydrolysis to yield verrucarinolactone ( 8 ), acetonitrile ( 26 ) and methyl adipaldohydate ( 27 ) by a heterolytic Beckmann fragmentation reaction.
Offshore wind measurements using Doppler aerosol wind lidar (DAWN) at NASA Langley Research Center (2014)

The latest flight demonstration of Doppler Aerosol Wind Lidar (DAWN) at NASA Langley Research Center (LaRC) is presented. The goal of the campaign was to demonstrate the improvement of DAWN system since the previous flight campaign in 2012 and the capabilities of DAWN and the latest airborne wind profiling algorithm APOLO (Airborne Wind Profiling Algorithm for Doppler Wind Lidar) developed at LaRC. The comparisons of APOLO and another algorithm are discussed utilizing two and five line-of-sights (LOSs), respectively. Wind parameters from DAWN were compared with ground-based radar measurements for validation purposes. The campaign period was June – July in 2013 and the flight altitude was 8 km in inland toward Charlotte, NC, and offshores in Virginia Beach, VA and Ocean City, MD. The DAWN system was integrated into a UC12B with two operators onboard during the campaign.
Effects of In Ovo Hormone Administration at Day Eighteen of Embryogenesis on Posthatch Growth of Broilers (1994)

The effect of in ovo administration of hormones on broiler growth were investigated. In Experiment 1, fertile eggs were injected on day 18 of incubation with bovine growth hormone (pGH), porcine growth hormone (pGH), thyrotropin-releasing hormone (TRH), or vehicle. Hormone administration increased the body weights of males at 1 and 3 wk posthatch. In Experiment 2, fertile eggs were injected with pGH, TRH, or vehicle. A 27% protein diet was fed to 4 wk, and a 22% protein diet was fed from 4 to 8 wk. In Experiment 3, fertile eggs were injected with ovine growth hormone (oGH), TRH, or vehicle. The body weights of females increased at wk 6 following pGH treatments in Experiment 2 and at wk 4, 6 and 8 for oGH-treated birds fed a 22% protein diet from 0-8 wk in Experiment 3. Day 18 of in ovo administration of hormones did not persistently increase body weights except in oGH-treated females fed a 22% protein diet throughout the study.
Innentitelbild: Molecularly Designed Nanoparticles by Dispersion of Self‐Assembled Organosiloxane‐Based Mesophases (Angew. Chem. 35/2014) (2014)

Hybridnanopartikel mit einem SiO2-Kern und einer organischen Schale beschreiben K. Kuroda, A. Shimojima und Mitarbeiter in ihrer Zuschrift auf S. 9327 ff. Eine neue Art von Oligosiloxanverbindungen bildet inverse Mesostrukturen, die durch Dispergieren in einem unpolaren Lösungsmittel in die entsprechenden Kern-Schale-Nanopartikel umgewandelt werden können. Durch In-situ-Verkapselung von Fluoreszenzfarbstoffen wurde gezeigt, dass die Hybridpartikel als Nanotransporter agieren können.
Laser Beam Activation of CNT‐Filled Polymer Blends (2015)

Abstract 3D‐Molded Interconnect Devices enable the placement of electronic circuits on three‐dimensional plastic components. The following article breaks new ground in order to add reasonably to existing 3D‐MID procedures. An essential aspect was the shortening of the process chain of the conventional MID procedures through laser‐direct structuring. Thus the metallising steps are no longer necessary and a 3D circuit carrier structure can be created directly on any plastic component. The research work focused on the space‐resolved modification of the electric conductivity of non‐conductive plastic components through a newly‐developed procedure of laser beam functionalisation. The principle is based on the application of multi‐phase polymer blends with matrix‐disperse phase structures in which carbon nanotubes are located. They cross‐link on the component surface through a partial laser activation and create a conductive area.
Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP. (1998)

IL-2 gene transcription in T cells requires both TCR and costimulatory signals. IL-2 promoter activation in Jurkat T cells stimulated with superantigen presented by Raji B cells requires CD28 activation. The addition of rCTLA4Ig, which blocks CD28 binding to its ligand, to the cultures decreased IL-2 promoter activation by >80%. Interestingly, CTLA4Ig did not significantly inhibit the activation of either NF of activated T cells (NFAT) or AP-1 reporters. Therefore, activation of NFAT and AP-1 is insufficient for IL-2 promoter activation. In contrast, an RE/AP reporter was blocked by CTLA4Ig by >90%. Thus, the requirement for CD28 in IL-2 promoter activation appears to be due to RE/AP and not the NFAT or AP-1 sites. In addition, these data suggest that transcriptional activation of RE/AP is not mediated by NFAT, because activation of a NFAT reporter is not affected by the addition of CTLA4Ig.
Binary Access Memory: An optimized lookup table for successive approximation applications (2011)

An optimized memory structure, Binary Access Memory (BAM), is presented for successive approximation applications that employ an error correction lookup table. Unlike true random-access memory, the probability of different codes occurring in a binary successive approximation access pattern is not uniformly distributed. BAM exploits this fact in several ways to reduce the number of sub-block switches, the average and worst-case access latency, and power consumption compared to a conventional SRAM lookup table. A simple technique for using BAM in an asynchronous successive approximation design is also presented.
Biomedical Characteristics of Primate Placenta: Transfer of Gene-therapeutic Materials to Fetuses (2001)

Gene therapy or DNA vaccination involves gene delivery systems and methods which influence on the efficacy and the risk of the gene transfer. Establishment of a monkey model to assess the efficiency and the safety of the materials is necessary, because monkeys have similar genomic nature, biomedical and immunological responses to those of humans.Here we overview the structure of primate placenta, focusing on the maternofeto placental barrier to evaluate monkeys as an experimental model for gene transfer during pregnancy. Placentae of humans and monkeys are hemochorial type and have only one layer of trophoblast which contacts with maternal blood, while other conventional experimental animals (rats and mice) have two or three layers of the trophoblast. Thus, it is concluded that the monkey model is the most suitable to estimate the material transfer to fetuses through placenta.We also showed gene transfer experiments on pregnant marmosets. In our study, GFP DNA/liposome vector was administered to marmosets at full term, and GFP DNA and GFP protein were both detected in fetal tissues. It indicates the necessity of careful administration of the liposome vectors during pregnancy and also suggests the feasibility of gene therapy and DNA vaccination to fetuses.
Combining Bevacizumab with Radiation or Chemoradiation for Solid Tumors: A Review of the Scientific Rationale, and Clinical Trials (2012)

Radiation therapy or the combination of radiation and chemotherapy is an important component in the local control of many tumor types including glioblastoma, rectal cancer, and pancreatic cancer. The addition of anti-angiogenic agents to chemotherapy is now standard treatment for a variety of metastatic cancers including colorectal cancer and non-squamous cell lung cancer. Anti-angiogenic agents can increase the efficacy of radiation or chemoradiation for primary tumors through mechanisms such as vascular normalization and augmentation of endothelial cell injury. The most commonly used anti-angiogenic drug, bevacizumab, is a humanized monoclonal antibody that binds and neutralizes vascular endothelial growth factor A (VEGF-A). Dozens of preclinical studies nearly uniformly demonstrate that inhibition of VEGF-A or its receptors potentiates the effects of radiation therapy against solid tumors, and this potentiation is generally independent of the type or schedule of radiation and timing of VEGF-A inhibitor delivery. There are now several clinical trials combining bevacizumab with radiation or chemoradiation for the local control of various primary, recurrent, and metastatic tumors, and many of these early trials show encouraging results. Some added toxicities occur with the delivery of bevacizumab but common toxicities such as hypertension and proteinuria are generally easily managed while severe toxicities are rare. In the future, bevacizumab and other anti-angiogenic agents may become common additions to radiation and chemoradiation regimens for tumors that are difficult to locally control.