gebhart/patrepeval huggingface dataset:
Abstract 16672: Determining the Diagnostic Yield for Atrial Fibrillation Using Continuous Smartwatch Monitoring (2018)

Introduction: Smartwatch technologies become ubiquitous in our daily life and can contribute to better health. The optical sensing element (photoplethysmography or PPG) enables continuous heart rate and heart rhythm monitoring. However, signal quality is a major challenge to overcome to improve the diagnostic yield. Hypothesis: To compare the diagnostic yield of AF detection between traditional 24h Holter and continuous wearable monitoring. Methods: In this study, patients receiving a diagnostic 24h ECG Holter monitor were parallel provided with a wearable smartwatch device capable of continuous PPG logging. Data was recorded up to 24 hours and the ECG and PPG signals were synchronized. The PPG signals were analyzed by the FibriCheck algorithms and compared towards the Holter analysis results. Results: In total, 100 patients participated in the study with a mean age of 60±13 years and 53.8% was male. Over 142,560 minutes of data have been collected from both Holter and wearable device. On average, 45% of the data was labeled as insufficient quality. There was a significant (P&lt;0.001) difference in presence of bad quality between day (47.5%) and night (10.6%). In total, on Holter, 9.6% of the data was labelled as atrial fibrillation, while on the PPG signal only 6.5% AF was found. Missing AF occurred during episodes of insufficient quality, impacting the diagnostic yield. Without a quality detection system, a over-diagnostic rate of 48.1% AF was observed. Conclusions: Initial results indicate the feasibility of continuous heart rhythm monitoring using wearable systems. However, optimizing the diagnostic yield remains a challenge. Diagnostic results obtained during the night are in high agreement between Holter and wearable.
Introducing changes at work: How voice behavior relates to management innovation (2018)

Summary This multistudy research examines the unit‐level relationship between promotive voice behavior and management innovation. Study 1 utilizes multisource data from 62 work units and reports that willingness to discuss ideas mediates the unit‐level relationship between promotive voice and management innovation. The results of Study 1 also show that the unit's available resources make the relationship stronger between promotive voice and willingness to discuss ideas. Study 2 employs a scenario‐based design to constructively replicate and expand the results of Study 1, utilizing a sample of 100 working adults. The results of the second study also show that resource availability positively moderates the relationship between promotive voice and willingness to discuss ideas. Furthermore, Study 2 shows that the indirect effect of promotive voice on management innovation through willingness to discuss ideas is stronger when more resources are made available to the work units. This moderated‐mediation effect is shown to be significant using two different operationalizations of management innovation. The implications for theory and practice are discussed.
Recent advances on supercritical fluid extraction of essential oils (2011)

Supercritical fluid extraction (SFE) is one of the most commonly used extraction techniques in the course of analysis or preparation. It is environmentally friendly and has some advantages over other conventional extraction methods. This review covers the recent developments of SFE in the extraction of essential oils from the plant materials during the period 2005 to 2011, in particular some factors influencing SFE extraction yield, its characteristics and applications. &nbsp; Key words:&nbsp;Supercritical fluid extraction, essential oils, review.
Magnetic field distribution in large two-dimensional Josephson junctions (1983)

Asymptotic approach to the theory of large ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">a \ll \lambda_{J}</tex> ) two-dimensional Josephson junction is developed. As a result, the usual dc sine-Gordon equation for the rapidly changing Josephson phase difference φ is reduced to the much more simple hydrodynamic-type equations <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">div\{A(k)\rightarrow{k}\} = 0</tex> , curl <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\rightarrow{k} = 0</tex> , for the slowly changing wave vector <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\rightarrow{k}</tex> (A is a simple function of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</tex> ). The reduced equations are applied for analysis of a square-shaped Josephson junction and are solved using the rigorous boundary conditions. The obtained dependence of the junction critical current on the applied magnetic field is discussed and compared with the recent experimental data.
Pharmacogenomics of Vincristine‐Induced Peripheral Neuropathy Implicates Pharmacokinetic and Inherited Neuropathy Genes (2018)

Vincristine is an effective chemotherapeutic drug for various cancers, including acute lymphoblastic leukemia (ALL). Unfortunately, clinical utility is restricted by dose-limiting vincristine-induced peripheral neuropathies (VIPN). We sought to determine the association of VIPN with a recently identified risk variant, CEP72 rs924607, and drug absorption, distribution, metabolism, and excretion (ADME) gene variants in pediatric ALL. This was followed by a meta-analysis of pharmacogenomic data from over 500 patients. CEP72 rs924607 was significantly associated with VIPN (P = 0.02; odds ratio (OR) = 3.4). ADME analyses identified associations between VIPN and ABCC1 rs3784867 (P = 5.34 × 10<sup>-5</sup> ; OR = 4.9), and SLC5A7 rs1013940 (P = 9.00 × 10<sup>-4</sup> ; OR= 8.6); genes involved in vincristine transport and inherited neuropathies, respectively. Meta-analysis identified an association with a variant related to TTPA (rs10504361: P = 6.85 × 10<sup>-4</sup> ; OR = 2.0), a heritable neuropathy-related gene. This study provides essential corroboratory evidence for CEP72 rs924607 and highlights the importance of drug transporter and inherited neuropathy genes in VIPN.
Entropy of labeled versus unlabeled networks (2022)

The structure of a network is an unlabeled graph, yet graphs in most models of complex networks are labeled by meaningless random integers. Is the associated labeling noise always negligible, or can it overpower the network-structural signal? To address this question, we introduce and consider the sparse unlabeled versions of popular network models, and compare their entropy against the original labeled versions. We show that labeled and unlabeled Erdos-Renyi graphs are entropically equivalent, even though their degree distributions are very different. The labeled and unlabeled versions of the configuration model may have different prefactors in their leading entropy terms, although this remains conjectural. Our main results are upper and lower bounds for the entropy of labeled and unlabeled one-dimensional random geometric graphs. We show that their unlabeled entropy is negligible in comparison with the labeled entropy. This means that in sparse networks the entropy of meaningless labeling may dominate the entropy of the network structure. The main implication of this result is that the common practice of using exchangeable models to reason about real-world networks with distinguishable nodes may introduce uncontrolled aberrations into conclusions made about these networks, suggesting a need for a thorough reexamination of the statistical foundations and key results of network science.
Synthesis of a novel bifunctional nanocomposite with tunable upconversion emission and magnetic properties (2015)

A method of Co<sup>2+</sup> ions codoping for significantly enhancing upconversion emission intensity and simultaneous controlling sparamagnetic properties in β-NaYF<sub>4</sub>:Yb/Er nanoparticles, with well maintaining their morphology and highly disperse.
Clock-Controlled and FLOWERING LOCUS T (FT)-Dependent Photoperiodic Pathway in Lotus japonicus I: Verification of the Flowering-Associated Function of an FT Homolog (2013)

During the last decade, significant research progress in the study of Arabidopsis thaliana has been made in defining the molecular mechanism by which the plant circadian clock regulates flowering time in response to changes in photoperiod. It is generally accepted that the clock-controlled CONSTANS (CO)-FLOWERING LOCUS T (FT)-mediated external coincidence mechanism underlying the photoperiodic control of flowering time is conserved in higher plants, including A. thaliana and Oryza sativa. However, it is also assumed that the mechanism differs considerably in detail among species. Here we characterized the clock-controlled CO-FT pathway in Lotus japonicus (a model legume) in comparison with that of A. thaliana. L. japonicus has at least one FT orthologous gene (named LjFTa), which is induced specifically in long-days and complements the mutational lesion of the A. thaliana FT gene. However, it was speculated that this legume might lack the upstream positive regulator CO. By employing L. japonicus phyB mutant plants, we showed that the photoreceptor mutant displays a phenotype of early flowering due to enhanced expression of LjFTa, suggesting that LjFTa is invovled in the promotion of flowering in L. japonicus. These results are discussed in the context of current knowledge of the flowering in crop legumes such as soybean and garden pea.
CIRCAD: Automated Analysis of Circadian Core Temperature Data. (2000)

No accepted methodologies exist to study day-to-day changes in the characteristics of the circadian rhythm. Testing different methodologies using data processing and curve-fitting functions within Microsoft Excel and Jandel Sigmaplot is prohibitively expensive in terms of both time and personnel. Use of the CIRCAD program, described in this report, dramatically reduces the amount of time required for circadian data analyses and provides the capability to quickly implement and test new analytical methods. This Technical Note includes a brief description of the software, complete program listings in the appendices, and sample input and output including both worksheet samplers and graphs.
Picasso (2012)

Many applications can benefit from the capability to simultaneously and independently use arbitrarily sized but separate spectrum fragments with a single radio and antenna. By this capability we mean that the radio can simultaneously transmit, simultaneously receive, or simultaneously transmit and receive on arbitrary but separate spectrum fragments. For example, we can use it for spectrum aggregation in fragmented ISM bands as shown in as shown in Fig. 2(A). A WiFi AP can run independent OFDM PHY and CSMA MAC protocols on two WiFi channels to simultaneously serve two legacy WiFi clients assigned to different channels and achieve significantly higher throughput than a legacy AP that is restricted to use only one channel at a time. Similarly, a WiFi client radio with such a capability can use it to simultaneously connect to multiple WiFi APs on different channels and obtain a much higher aggregate throughput than current radios that can transmit or receive on only one channel at a time.
Containing the Cold War's Hot Waste (1998)

A new method for the construction, verification, and maintenance of underground vaults isolates and contains radioactive burial sites without excavation or drilling in contaminated areas. Two types of in situ containment methods—encapsulating radioactive waste in a single block of durable material or entombing it in a dry vault—are discussed. Both processes rely on patented grouting technology that potentially could increase the design life of landfills to 1,000 years.
A simple computer program for designing standard high-pressure sodium lamps (1984)

The last fifteen years have seen the introduction of several new types of high-pressure sodium lamp designed, over a range of power ratings, to give either very high efficacies or better colour characteristics. In order to design any of these lamps it is necessary to specify eleven variables. This paper shows how for one type of lamp (the standard high-pressure sodium lamp) a multiple regression procedure has been used to derive equations from experimentally observed relationships between efficacy, power, voltage, bore, arc tube length, arc tube wall thickness and sodium mole fraction. The equations have been brought together in a computer program so that new lamp designs can be obtained by keying in values for five variables; namely power, voltage, bore, wall thickness and sodium mole fraction. The program then calculates the current, arc length for maximum efficacy and the magnitude of the efficacy for each chosen combination of the variables. The optimum lamp design and ballast combination can then be selected from the calculated data.
[Effectiveness of prostaglandin treatment in idiopathic pulmonary hypertension]. (2007)

The therapy with iloprost is particularly effective in treating IPH.
Whole-Genome Shotgun Assembly and Analysis of the Genome of Streptomyces mobaraensis DSM 40847, a Strain for Industrial Production of Microbial Transglutaminase (2013)

Here, we report the draft annotated genome sequence of Streptomyces mobaraensis strain DSM 40847, which is used in industry to produce microbial transglutaminase. The genome sequence will allow for the characterization of the molecular mechanisms underlying the beneficial properties of this organism.
Cross-Sectional Reconstructions of Sickle Cell Hemoglobin Macrofibers. (1985)

We have succeeded in performing two-dimensional cross sectional image reconstructions of sickle cell hemoglobin (HbS) macrofibers. Macrofibers are long helical structures which are intermediates in the crystallization of deoxygenated sickle cell hemoglobin at low pH. Earlier work has established that macrofibers are aggregates of Wishner-Love double strands which consist of 2 half-staggered HbS molecules repeating every 64 A in the axial direction. Thin sections of embedded aggregating macrofiber cross sections reveal a dumbbell like pattern of double strands (Figure 2a,b) that is similar to the a-axis projection of the crystal structure. Approximately 5 rows with 10 double strands per row were identified in the cross section, but structural features in the thin sections were obscured by an approximately 15 degree rotational blur due to the finite thickness (400 A) of the helical section, the ill defined boundaries of the section due to uneven staining, and apparent particle damage. These structural features have now been resolved in reconstructed cross sections obtained using a real space filtered back projection algorithm.
Associations of Il-1 Family-Related Polymorphisms With Gastric Cancer Risk and the Role of Mir-197 In Il-1f5 Expression (2015)

To explore whether the roles of IL-1 family single nucleotide polymorphisms (SNPs) of the microRNA binding sites (miR-SNPs) in the 3' untranslated region (3'-UTR) of their target genes in the progression of gastric cancer (GC) and verify the relationship between miR-197 with chronic inflammatory gene-IL1-F5 by microRNA target prediction, a case-control study which consisted of 500 cases and 500 frequency-matched healthy controls was conducted. Single nucleotide polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or allele-specific PCR (AS-PCR). Association between SNPs and GC risk was evaluated by adjusted odds ratios (ORs) and 95% confidence intervals (CIs) in unconditional logistic regression analyses. Quantitative real-time (qRT) PCR assay and Western Blot analyses were performed to analyze the miR-197 expression and the IL1-F5 expression. The variant homozygote and heterozygote genotype of rs9005 in IL-1RN were significantly associated with increased risks of GC (ORadjusted [95%CI]: 1.71[1.04-2.81] and ORadjusted[95%CI]: 1.36 [1.04-1.78]). Compared with the wild heterozygote genotype, the variant heterozygote genotype of rs2472188 and rs2515401 in IL-1F5 polymorphisms were significantly associated with increased GC risks (ORadjusted [95%CI]: 1.51[1.15-1.99] and ORadjusted[95%CI]: 1.36[1.04-1.76]), but no significant differences existed in other 7 IL-1 family SNPs (rs2856836 in IL-1A, rs3732131 in IL-1R1, rs1135354 and rs3771157 in IL-18RA, rs3180235, rs957201 and rs2515402 in IL-1F5) with GC. The recombinant plasmid-pGenesil-1-miR-197 could upregulate the expression of miR-197 and downregulate the expression of IL-1F5 in human gastric cancer cell lines SGC-7901 and BGC-823 cells after transfection, and the miR-197 inhibitor could facilitate the expression of IL1-F5 after transfecting the same cell lines. These results suggested that SNPs in the IL-1 family genes play important roles in the development of GC and the IL-1F5 might be the target gene of miR-197, and miR-197 might negatively regulate its expression.
Reduced cholesterol transmucosal transport in rats with inhibited mucosal acyl CoA:cholesterol acyltransferase and normal pancreatic function. (1984)

Absorption of cholesterol during inhibition of mucosal acyl CoA:cholesterol acyltransferase was studied in mesenteric lymph fistula rats with normal pancreatic function. The specific inhibitor used (Sandoz Compound 58-035; 3-(decyldimethylsilyl)-N-[2-(4-methylphenyl)-1-phenylethyl]prop anamide) greatly reduced cholesterol esterification in vitro and decreased lymphatic secretion of esterified cholesterol in vivo, but did not affect triglyceride metabolism by the gut in vitro or in vivo. During steady state lymphatic transport of cholesterol, unesterified cholesterol was increased and cholesteryl esters were decreased in whole lymph, lymph chylomicrons, and very low density lipoproteins. Incorporation of labeled cholesterol infused into the lumen into cholesteryl esters of lymph very low density lipoproteins was particularly suppressed. Labeled cholesterol incorporation into individual cholesteryl esters differed and was differentially affected when total cholesteryl ester synthesis was inhibited. The results support a major regulatory role for mucosal acyl CoA:cholesterol acyltransferase in cholesterol absorption and imply differences in the metabolism of endogenous and exogenous cholesterol by the intestinal mucosa.
Neurofibromatosis, Phenotype, Natural History, and Pathogenesis (1992)

NF1: historical background and introduction clinical and epidemiologic features evaluation and management genetics molecular biology and pathogenesis neurofibromas and malignanat peripheral nerve sheath tumours cognitive function and academic performance nervous system abnormalities optic pathway tumours other malignancies skeletal system vascular and endocrine abnormalities. NF2: clinial aspects associated tumours molecular biology. Appendix: resources for neurofibromatosis patients and their families.
Ethanol SCC Research on PWHT Effects and Threshold Stress Determination (2011)

Abstract Recently a laboratory testing program was completed that covers an important and yet unexplored area of ethanol stress corrosion cracking (eSCC) of steel equipment in ethanol distribution and blending facilities. This program aimed at generating new data on the effects of post weld heat treatment (PWHT) on eSCC and also attempted to determine the threshold stresses required for eSCC. These two topics are related as the effectiveness of PWHT is based on lowering of the levels of welding-induced residual stresses in the fabricated piece to less than the threshold stress of SCC. Therefore, these two tasks will help identify acceptable guidelines for PWHT and increase confidence in field practices, thereby (a) reducing the risk of future SCC failures, and (b) providing better definition of PWHT time and temperature parameters appropriate for eSCC. The paper describes in detail the various testing methodologies and the important findings of this research program.
Affinity-labelling of the thyrotropin receptor. Characterization of the photoactive ligand (1985)

Thyrotropin (TSH) has been coupled to the photoactive heterobifunctional reagent N-hydroxysuccinimidyl 4-azidobenzoate (HSAB) and the properties of the product (HSAB-TSH) investigated. Preparations of HSAB-TSH containing two molecules of HSAB per molecule of TSH were used in most experiments and these preparations retained about 40% of the original receptor-binding activity of the TSH. HSAB-TSH could be labelled with 125I and cross-linked to porcine and human TSH receptors. Analysis of the cross-linked complexes indicated that the receptors consisted of two subunits (designated A and B) linked by a disulphide bridge. In the case of the human TSH receptor, the A- and B-subunits had approximate Mr values of 50 000 and 30 000 respectively, whereas the Mr values for porcine TSH-receptor A- and B-subunits were approx. 45 000 and 25 000 respectively. Only the A subunit was cross-linked to TSH. Comparison of the effects of trypsin and mercaptoethanol on the TSH-TSH-receptor complexes suggested that the trypsin cleavage point on the A-subunit was at a point close to the disulphide bridge.
ChemInform Abstract: SYNTHESIS OF ALKYLPHOSPHORANES (1973)

Abstract Durch Behandlung der aus den Phosphinoxiden (I) bzw. (IV) erhältlichen Ph phoniumsalze (II) bzw. (V) mit Phenyl‐Li bzw. Methyl‐Li konnten die stabil Homocubylphosphorane (III) bzw. (VI) dargestellt werden.
Real-time time-dependent density functional theory in Quantum Espresso and related codes (2020)

A set of subroutines that interact with an existing computer program, Quantum Espresso (QE), that takes a set of electronic orbitals from QE and propagates them forward in time in response to a number of perturbations. These perturbations include the motion of ions and a wide spectrum of applied electromagnetic fields (e.g., static magnetic fields, slowly-varying electric fields, x-rays, etc.). From the time evolution of the electronic orbitals comes time-varying values of physical observables like the electronic charge and current densities and atomic forces. These are further post-processed to yield properties of interest like stopping powers, conductivities, and the dynamic structure factor. The electronic orbitals are described in a plane wave basis and the equations of motion are carried out using a unitary or approximately unitary time propagation algorithm. Related work will include subroutines for interfacing this capability, as well as others that already exist within QE, with a fork of QE that is more extensible and modular.SAND2019-12611 M Sandia National Laboratories is a multimission laboratory managed and operated by National Technology &amp; Engineering Solutions of Sandia, LLC, a wholly owned subsidiary of Honeywell International Inc., for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-NA0003525.
Crossover from diffusive to ballistic transport as a function of frequency in a two dimensional electron gas (2004)

Ballistic transport is nothing but an electron transport in the limit (/spl omega//spl tau//sub m/ > 1); the electron move without scattering between electric field cycles. Diffusive transport can be defined as the lower frequency range (/spl omega//spl tau//sub m/<1); in the diffusive limit there are many scattering events between electric field cycles. Here we measure for the first time the crossover from diffusive to ballistic transport as a function of frequency in a dc contacted 2DEG.