gebhart/patrepeval huggingface dataset:
Beyond Immunosuppression: The Multifaceted Functions of Tumor-Promoting Myeloid Cells in Breast Cancers (2022)

Breast cancers are commonly associated with an immunosuppressive microenvironment responsible for tumor escape from anti-cancer immunity. Cells of the myeloid lineage account for a major part of this tumor-promoting landscape. These myeloid cells are composed of heterogeneous subsets at different stages of differentiation and have traditionally been described by their cardinal ability to suppress innate and adaptive anticancer immunity. However, evidence has accumulated that, beyond their immunosuppressive properties, breast cancer-induced myeloid cells are also equipped with a broad array of "non-immunological" tumor-promoting functions. They therefore represent major impediments for anticancer therapies, particularly for immune-based interventions. We herein analyze and discuss current literature related to the versatile properties of the different myeloid cell subsets engaged in breast cancer development. We critically assess persisting difficulties and challenges in unequivocally discriminate dedicated subsets, which has so far prevented both the selective targeting of these immunosuppressive cells and their use as potential biomarkers. In this context, we propose the concept of IMCGL, "pro-tumoral immunosuppressive myeloid cells of the granulocytic lineage", to more accurately reflect the contentious nature and origin of granulocytic cells in the breast tumor microenvironment. Future research prospects related to the role of this myeloid landscape in breast cancer are further considered.
Rapid disease progression following discontinuation of ibrutinib in patients with chronic lymphocytic leukemia treated in routine clinical practice (2019)

We identified all patients with chronic lymphocytic leukemia at Mayo Clinic treated with ibrutinib outside the context of a clinical trial; timing and reasons for discontinuation were ascertained, as were symptoms, exam and radiographic findings, and laboratory changes following discontinuation. Of 202 patients who received ibrutinib, 52 discontinued therapy (estimated 1- and 2-year risk of discontinuation 18% and 28%, respectively). The most common reasons for discontinuation were toxicity (56%) and progression of disease (32%, including Richter's transformation in 15%). Rapid progression of disease within 4 weeks after discontinuation was observed in 9/36 (25%) patients with adequate records for review, mostly in those stopping ibrutinib for disease progression (<i>n</i> = 8) rather than toxicity (<i>n</i> = 1). This was evident by sudden worsening of disease-related symptoms (<i>n</i> = 9), exam/radiographic changes (<i>n</i> = 7), and laboratory changes (<i>n</i> = 8). An estimated one in every three patients discontinued ibrutinib by 2 years, with 25% developing rapid disease progression afterwards.
Zhi#: Programming Language Inherent Support for XML Schema Definition (2005)

Recently, XML Schema Definition (XSD) has become ever more important when it comes to define programming language independent content models and type systems. However, writing software that operates on XML instance documents still suffers from a lack of compile time support for XSD. Especially, obeying facet based constraints imposed on XSD simple data types is still error prone and laborious. This paper introduces the concept of XSD aware compilation. Zhi# provides static- and dynamic type checking for XML simple data types, which can be used along with off-the-shelf implementations of the W3C XML DOM.
Design and Evaluation of Chelating Resins through EDTA- and DTPA-Modified Ligands (2015)

Ion-exchange resins through EDTA or DTPA moieties are synthesized and evaluated for the co-extraction of Cs+ and Sr2+ radionuclides for wastewater treatment. EDTA-bis(amide) and DTPA-bis(amide) derivatives bearing phenol or catechol moieties obtained from tyramine or dopamine, respectively, were used as building blocks to prepare ion-exchange resins. Their synthesis involved the condensation of formaldehyde with various phenolic rings, catechol (C), resorcinol (R), or calixresorcinarene (CR) under alkaline conditions. The resulting formo-phenolic-like resins have both ion-exchange and chelating groups in their structure and are indeed efficient in the remediation of Cs+ and Sr2+, even in salted aqueous solutions.
Preference-balancing motion planning under stochastic disturbances (2015)

Physical stochastic disturbances, such as wind, often affect the motion of robots that perform complex tasks in real-world conditions. These disturbances pose a control challenge because resulting drift induces uncertainty and changes in the robot's speed and direction. This paper presents an online control policy based on supervised machine learning, Least Squares Axial Sum Policy Approximation (LSAPA), that generates trajectories for robotic preference-balancing tasks under stochastic disturbances. The task is learned offline with reinforcement learning, assuming no disturbances, and then trajectories are planned online in the presence of disturbances using the current observed information. We model the robot as a stochastic control-affine system with unknown dynamics impacted by a Gaussian process, and the task as a continuous Markov Decision Process. Replacing a traditional greedy policy, LSAPA works for high-dimensional control-affine systems impacted by stochastic disturbances and is linear in the input dimensionality. We verify the method for Swing-free Aerial Cargo Delivery and Rendezvous tasks. Results show that LSAPA selects an input an order of magnitude faster than comparative methods, rejecting a range of stochastic disturbances. Further, experiments on a quadrotor demonstrate that LSAPA trajectories that are suitable for physical systems.
Human Follicular Fluid Stimulates the Motility of Washed Human Sperm (1991)

Human follicular fluid (hFF) was collected by laparoscopic oocyte pickup during IVF to evaluate the effect of hFF on human sperm motility with a transmembrane migration method. Freshly ejaculated human sperm were washed with phosphate buffered saline (PBS) and mixed with either PBS or hFF. Amplitude of motility increases were 38% and 72% in washed fertile sperm and washed asthenozoospermic sperm when individual control motility was considered to be 100%. The stimulatory effect of hFF was lost when preheated at 100 degrees C for 30 minutes. hFF collected from mature follicles stimulated sperm motility better than that collected from intermediate or immature follicles. hFF did not stimulate the motility of unwashed sperm in freshly ejaculated human semen. A heat labile factor(s) in hFF may stimulate the motility of washed human sperm. Whether this factor could be used to improve the success rate of IVF and artificial insemination awaits further investigation.
Blockchain Consensus Algorithm Design Based on Consistent Hash Algorithm (2019)

Blockchain, the concept from Bitcoin created by Satoshi Nakamoto, has the potential to decentralise traditionally centralised systems. Blockchain is a distributed ledger for recording information, stored by many nodes without a central organization through distributed systems and cryptography. The consensus algorithm is a protocol that guarantees the consistency of all data in a blockchain system. It is a key for building a blockchain system and an important part that affects the performance of the blockchain system. In this paper, we firstly compare the usage scenarios of different consensus algorithms, their advantages and disadvantages. After that, we present a new consensus algorithm in permissioned blockchain based on consistent hashing. For blockchain system construction, we propose a new design of the hash ring. The pseudo-randomness of the hash operation is used to ensure the randomness of the electoral leadership node in the blockchain system. It avoids the security risk of the fixed leadership node model. Our algorithm is applicable to blockchain systems containing Byzantine nodes and has a high throughput, low delay and many other advantages. Its communication complexity is O(n), significantly better than that of the practical Byzantine fault tolerance algorithm whose communication complexity is O(n2).
Autoantibodies in Mothers of Children with Neonatal Liver Disease (2003)

The majority of cases of INC do not represent NLE. The frequent presence of autoantibodies in mothers of infants in all neonatal liver disease groups raises the possibility that maternal serologic autoimmunity is associated with neonatal liver disease.
Changes in Knee Laxity and Ligament Force After Sectioning the Posteromedial Bundle of the Posterior Cruciate Ligament (2006)

This study helps to elucidate the function of the PM bundle in the native PCL. Because only small changes were seen in the biomechanical parameters tested, the rationale for reconstructing this bundle of the PCL could be questioned.
Network structure and patterns of information diversity on Twitter (2016)

Social media have great potential to support diverse information sharing, but there is widespread concern that platforms like Twitter do not result in communication between those who hold contradictory viewpoints. Because users can choose whom to follow, prior research suggests that social media users exist in 'echo chambers' or become polarized. We seek evidence of this in a complete cross section of hyperlinks posted on Twitter, using previously validated measures of the political slant of news sources to study information diversity. Contrary to prediction, we find that the average account posts links to more politically moderate news sources than the ones they receive in their own feed. However, members of a tiny network core do exhibit cross-sectional evidence of polarization and are responsible for the majority of tweets received overall due to their popularity and activity, which could explain the widespread perception of polarization on social media.
Mapping the Intermedilysin-Human CD59 Receptor Interface Reveals a Deep Correspondence with the Binding Site on CD59 for Complement Binding Proteins C8α and C9 (2011)

CD59 is a glycosylphosphatidylinositol-anchored protein that inhibits the assembly of the terminal complement membrane attack complex (MAC) pore, whereas Streptococcus intermedius intermedilysin (ILY), a pore forming cholesterol-dependent cytolysin (CDC), specifically binds to human CD59 (hCD59) to initiate the formation of its pore. The identification of the residues of ILY and hCD59 that form their binding interface revealed a remarkably deep correspondence between the hCD59 binding site for ILY and that for the MAC proteins C8α and C9. ILY disengages from hCD59 during the prepore to pore transition, suggesting that loss of this interaction is necessary to accommodate specific structural changes associated with this transition. Consistent with this scenario, mutants of hCD59 or ILY that increased the affinity of this interaction decreased the cytolytic activity by slowing the transition of the prepore to pore but not the assembly of the prepore oligomer. A signature motif was also identified in the hCD59 binding CDCs that revealed a new hCD59-binding member of the CDC family. Although the binding site on hCD59 for ILY, C8α, and C9 exhibits significant homology, no similarity exists in their binding sites for hCD59. Hence, ILY and the MAC proteins interact with common amino acids of hCD59 but lack detectable conservation in their binding sites for hCD59.
CW (Continuous Wave) HF R-Branch Laser. (1986)

Abstract : A continuous wave HF R-branch chemical laser uses a linear array nozzle system having primary and secondary nozzles for exciting HF and a laser resonator having mirrors with reflectance to discriminate against P-branch lasing of the excited Hydrogen Fluoride. (Author)
Non-antibiotic pharmaceuticals promote the transmission of multidrug resistance plasmids through intra- and intergenera conjugation (2021)

Antibiotic resistance is a global threat to public health. The use of antibiotics at sub-inhibitory concentrations has been recognized as an important factor in disseminating antibiotic resistance via horizontal gene transfer. Although non-antibiotic, human-targeted pharmaceuticals are widely used by society (95% of the pharmaceuticals market), the potential contribution to the spread of antibiotic resistance is not clear. Here, we report that commonly consumed, non-antibiotic pharmaceuticals, including nonsteroidal anti-inflammatories (ibuprofen, naproxen, diclofenac), a lipid-lowering drug (gemfibrozil), and a β-blocker (propranolol), at clinically and environmentally relevant concentrations, significantly accelerated the dissemination of antibiotic resistance via plasmid-borne bacterial conjugation. Various indicators were used to study the bacterial response to these drugs, including monitoring reactive oxygen species (ROS) and cell membrane permeability by flow cytometry, cell arrangement, and whole-genome RNA and protein sequencing. Enhanced conjugation correlated well with increased production of ROS and cell membrane permeability. Additionally, these non-antibiotic pharmaceuticals induced responses similar to those detected when bacteria are exposed to antibiotics, such as inducing the SOS response and enhancing efflux pumps. The findings advance understanding of the transfer of antibiotic resistance genes, emphasizing the concern that non-antibiotic, human-targeted pharmaceuticals enhance the spread of antibiotic resistance among bacterial populations.
Introductory Chapter (2012)

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Polymer-optical sensor glove prototype based on eccentric FBGs (2023)

We report on the development, test and comparison of a prototype sensor glove for 3D shape detection of the human hand. The prototype is based on polymer optical fibers with eccentrically inscribed Bragg gratings, which are mantled with a simple jacket woven into a textile fabric glove. All of these elements are lightweight and flexible, taking away the drawback of motion handicaps, that sensor gloves usually come with due to material stiffness. The sensor glove is tested with a set of approximately 15 different and simply defined hand gestures, which incorporate iconic and everyday gestures like grasping a cylindrical shape or showing numbers with fingers, assisted with 3D printed models. Hence a set of gestures is defined, subsequently we compared two commercial systems based on optical sensors from 5DT (Data Glove 5/ 14 Ultra) with the prototype. The prototype is not capable to measure motion accurately yet, due to its long integration times as of now, it is, however, advanced in the measurement accuracy, especially regarding the direction of the shape deformation, which is rendered possible by the structure of the FBG sensor. In the next steps, the integration time of the sensor, as well as its illumination and the evaluation will be improved. For that step, the light source, the optical spectrum analyzer and the computer will be replaced by integrated devices like LEDs, photodiodes and single-board microcontrollers. In the future, the gloves, as well as the used technology of the sensor, offer the potential for application in logistics, virtual and augmented reality as well as medical diagnostics and general observation.
Ivermectin Toxicity in 17 Collies (2002)

Abstract Ivermectin is widely used in veterinary medicine as an anthelminthic and generally has a wide margin of safety, but Collies are prone to ivermectin toxicity. Two groups of Collies were presented to the University of California Veterinary Medical Teaching Hospital (VMTH) with ivermectin toxicity. The medical records of the 2 groups of Collies were reviewed retrospectively. Group I comprised 5 adult Collies that received at least 400 μg/kg ivermectin PO and were presented to the VMTH 3 hours after intoxication. These Collies showed marked clinical signs on presentation. Three of these dogs required mechanical ventilation and were euthanized for financial reasons; the remaining 2 dogs were comatose but recovered in 5–7 days. Group II was comprised of 12 adult Collies presented to the VMTH 2 days (n = 10) and 5 days (n = 2) after subcutaneous injection of 200–250 μg/kg ivermectin. These animals showed greater variation in severity of illness among individuals; 5 animals progressed to stupor or coma, whereas 4 animals remained ambulatory. Most of these dogs' clinical signs deteriorated from the day of intoxication until approximately day 6, from which time they showed gradual but steady improvement. All of the Collies in this group survived, but it took 3 weeks for most of them to recover. Collies suffering from ivermectin toxicity can have a severe and prolonged clinical course requiring intensive nursing care. Respiratory, cardiovascular, and nutritional support may all be required. With appropriate care, however, the prognosis for complete recovery is good.
New Relative Concatenate Sorting algorithm (2012)

Sorting is technique by which elements are arranged in a particular order following some characteristic or law [1]. In this paper we presented an algorithm called as Relative Concatenate Sort, which is based on the idea of Selection Sort, but it divides the list into two. After dividing the list it takes the average of both halves of the list. Comparing this average with elements it sorts both arrays and then put these arrays together to get the final sorted list.
An experimental display structure based on reversible electrodeposition (1978)

Films of halide complexes of silver can be electrodeposited onto, or removed from, transparent indium tin oxide contacts in less than 10 msec using a clear liquid mixture of dimethyl sulfoxide (DMSO), silver halide, alkali metal halide, and bromine or iodine. The solutions do not attack the contacts, even at high voltages, as long as adequate silver remains in solution. Variations include a mulled mixture of an opacifier and superionic conductor particles in a variety of organic solvents. The electro-optic properties of experimental display structures are discussed.
When Private Set Intersection Meets Big Data: An Efficient and Scalable Protocol. (2013)

Large scale data processing brings new challenges to the design of privacy-preserving protocols: how to meet the increasing requirements of speed and throughput of modern applications, and how to scale up smoothly when data being protected is big. Efficiency and scalability become critical criteria for privacy preserving protocols in the age of Big Data. In this paper, we present a new Private Set Intersection (PSI) protocol that is extremely efficient and highly scalable compared with existing protocols. The protocol is based on a novel approach that we call oblivious Bloom intersection. It has linear complexity and relies mostly on efficient symmetric key operations. It has high scalability due to the fact that most operations can be parallelized easily. The protocol has two versions: a basic protocol and an enhanced protocol, the security of the two variants is analyzed and proved in the semi-honest model and the malicious model respectively. A prototype of the basic protocol has been built. We report the result of performance evaluation and compare it against the two previously fastest PSI protocols. Our protocol is orders of magnitude faster than these two protocols. To compute the intersection of two million-element sets, our protocol needs only 41 seconds (80-bit security) and 339 seconds (256-bit security) on moderate hardware in parallel mode. 1
Physiological augmentation of esophageal distension pressure and peristalsis during conditions of increased esophageal emptying resistance (2017)

Intrabolus pressure and contractile vigor are indicative of the physiological modulation of bolus transport mechanisms. Provocative testing by abdominal compression induces changes in these esophageal bolus dynamics.
Mesenchymal stromal cell-derived exosome-rich fractionated secretome confers a hepatoprotective effect in liver injury (2018)

The work presented is a proof of concept that fractionating the secretome enriches certain bioactive molecules involved in the repair and recovery of injured liver tissue. Exosome enriched mesenchymal stromal cell-derived fractionated secretome potentiates recovery upon injection in injured liver.
Establishment and Characterization of Primary Glioblastoma Cell Lines from Fresh and Frozen Material: A Detailed Comparison (2013)

Our simple cryopreservation procedure facilitates collection, long-time storage and propagation (modeling) of clinical GBM specimens (potentially also from distant centers) for basic research, (pre-) clinical studies of novel therapies and individual response prediction.
Leukotriene B4 enhances activation, proliferation, and differentiation of human B lymphocytes. (1989)

Highly purified human tonsillar B lymphocytes at different stages of activation were incubated with leukotriene B4 (LTB4). As a key marker for activation, we used the CD23 Ag. LTB4 enhanced the CD23 expression on resting B cells in synergy with B cell-stimulating factors from 4% to 50%. Maximal effect of LTB4 was observed at 10(-10) M to 10(-12) M. LTB4 also augmented the S and M phase entries as well as Ig secretion in synergy with IL-2 and IL-4. In contrast, 5S,12S-dihydroxyeicosatetraenoic acid, an isomer of LTB4, and leukotriene C4 lacked these effects. The results indicate that LTB4 amplifies lymphokine-driven activation, replication, and differentiation of human B lymphocytes.
Simultaneous measurements of (p[downward right arrow],p[downward right arrow]ʹ) and (p[downward right arrow],pʹγ) observables for the 15.11 MeV, 1+, T=1 state in 12C at 200 MeV (1995)

The extension of singles (p↘,p↘′) studies to include coincident (p↘,p′γ) measurements can provide new information about the effective nucleon–nucleus interaction. We have therefore made simultaneous measurements of (p↘,p↘′) and (p↘,p′γ) observables for the 15.11 MeV, 1+, T=1 state in 12C at an incident beam energy of 200 MeV. Contained in these coincident observables are determinations of the sideways and longitudinal analyzing powers, D0S and D0L, which must vanish in singles measurements due to parity conservation. With this large data set on a transition with a relatively simple spin sequence, we have, in principle, enough information for a complete determination of the scattering amplitude.
Adhesion mechanisms at soft polymer interfaces (2007)

Based on several significant examples, we analyse the adhesion mechanisms at soft polymer interfaces with a special emphasis first on the role of connector molecules, that is, polymer chains bound to the interface and which transmit stress through a stretching and extraction mechanism, and second on the necessary relay that must be taken by additional dissipation mechanisms acting at larger scales if one wants to reach typical fracture toughnesses in the range of a few 10 J m(-2). Examples of such bulk dissipation mechanisms will be discussed for interfaces between polymer melts and for pressure-sensitive adhesives in contact with a solid surface. We shall particularly point out the fact that the level of adhesion results from a competition between adhesive failure usually driven by both the interactions and the friction properties of the interface and bulk strong deformations which take place in the bulk of the adhesive layer. Controlling the friction properties of the interface then becomes a tool to finely tune adhesive properties.
DETERMINATION OF BONE MINERAL LOSS IN THE AXIAL SKELETON OF OOPHORECTOMIZED WOMEN USING QUANTITATIVE COMPUTED TOMOGRAPHY. (1982)

Genant, Harry K.; Cann, Christopher E.; Ettinger, Bruce; Gordan, Gilbert S. Author Information