gebhart/patrepeval huggingface dataset:
Understanding the Semantic Structure of Noun Phrase Queries (2010)

Determining the semantic intent of web queries not only involves identifying their semantic class, which is a primary focus of previous works, but also understanding their semantic structure. In this work, we formally define the semantic structure of noun phrase queries as comprised of intent heads and intent modifiers. We present methods that automatically identify these constituents as well as their semantic roles based on Markov and semi-Markov conditional random fields. We show that the use of semantic features and syntactic features significantly contribute to improving the understanding performance. 1
Melting point and normal boiling point correlations: applications to rigid aromatic compounds (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMelting point and normal boiling point correlations: applications to rigid aromatic compoundsPahala Simamora, Allan H. Miller, and Samuel H. YalkowskyCite this: J. Chem. Inf. Comput. Sci. 1993, 33, 3, 437–440Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/ci00013a022https://doi.org/10.1021/ci00013a022research-articleACS PublicationsRequest reuse permissionsArticle Views699Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Heredity of Small Hard Drusen in Twins Aged 20–46 Years (2007)

Hard drusen are prevalent in young adults, and having more than 20 drusen per eye is a highly hereditary feature. Additional research is needed to determine whether the presence of small hard drusen correlates with the development of age-related macular degeneration later in life and to explore the relation to AMD genotypes.
Deuteron magnetic resonance study of the antiferroelectric phase of ND4D2PO4 (1974)

The O–D ⋯ O deuteron quadrupole coupling tensors have been determined in the antiferroelectric phase of ND4D2PO4. The results show that the antiferroelectric phase transition in ND4D2PO4 is connected with an order-disorder transition of the deuterons in the O–D ⋯ O bonds and that the Nagamiya model of hydrogen ordering is correct.
Generation of a vector doughnut beam from an internal mirror He–Ne laser (2014)

We demonstrate the direct generation of a vector doughnut mode from an internal mirror He-Ne laser using the spot defect method. A circular-shaped spot defect of ∼30 μm in diameter with low reflectivity created on the inner surface of a cavity mirror by laser ablation suppressed the oscillation of a Gaussian beam resulting in the oscillation of a doughnut beam. Polarization investigation showed that the generated beam was a vector hybrid mode.
Cover feature - Toward internet distributed computing (2003)

Emerging Internet uses-including peer-to-peer and grid computing-provide both a glimpse of and the impetus for evolving the Internet into a distributed computing, platform of unprecedented scale. Taking a longer view, the authors consider what would be needed to make the Internet an application-hosting platform: a networked, distributed counterpart of the hosting environment traditional operating systems provide to applications within a single node. The foundation of their proposed approach is to disaggregate and virtualize individual system resources as services that can be described, discovered, and dynamically configured at runtime to execute an application.
An underactuated propeller for attitude control in micro air vehicles (2013)

Traditional coaxial helicopter micro air vehicles use a large propeller motor in conjunction with two small servomotors to control thrust, pitch, and roll forces and moments. Quadrotors similarly generate these necessary forces and moments through the coordinated control of multiple actuators. We present a novel propeller architecture which allows a single motor and rotor to express such control by modulating the torque applied to one passively hinged, underactuated propeller. Flight tests of a two-motor coaxial helicopter demonstrate that such a system can provide active stability and control in a real flight system.
ChemInform Abstract: Melt Infiltration Approach to Ceramic Matrix Composites. (1988)

Abstract Preliminary structure and property results are reported for representative systems based on particulate and whisker SiC reinforcement in combination with CaSiO 3 , SrSiO 3 , and SrAlSi 2 O 8 , which demonstrate that melt infiltration offers an alternative route to the synthesis of fully dense ceramic matrix composites.
Enzymatic Cleavage of the Histydyl-Prolyl Bond of Proangiotensin by Carboxyl Proteinases fromAspergillus sojaeandScytalidium lignicolum (1981)

Journal Article Enzymatic Cleavage of the Histydyl-Prolyl Bond of Proangiotensin by Carboxyl Proteinases from Aspergillus sojae and Scytalidium lignicolum Get access Eiji Ichishima, Eiji Ichishima Laboratory of Enzymology and Microbial Chemistry, Tokyo Nōkō University, Fuchu, Tokyo 183, Japan To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Eiji Majima, Eiji Majima Laboratory of Enzymology and Microbial Chemistry, Tokyo Nōkō University, Fuchu, Tokyo 183, Japan Search for other works by this author on: Oxford Academic Google Scholar Makoto Emi, Makoto Emi Laboratory of Enzymology and Microbial Chemistry, Tokyo Nōkō University, Fuchu, Tokyo 183, Japan Search for other works by this author on: Oxford Academic Google Scholar Kazuya Hayashi, Kazuya Hayashi Central Research Laboratories of Kikkoman Corp., Noda, Chiba 278, Japan Search for other works by this author on: Oxford Academic Google Scholar Sawao Murao Sawao Murao Department of Agricultural Chemistry, University of Osaka Prefecture, Sakai, Osaka 591, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 45, Issue 10, 1 October 1981, Pages 2391–2393, https://doi.org/10.1080/00021369.1981.10864899 Published: 01 October 1981 Article history Received: 25 June 1981 Published: 01 October 1981
A phase-1 trial of linsitinib (OSI-906) in combination with bortezomib and dexamethasone for the treatment of relapsed/refractory multiple myeloma (2021)

We report results of a phase-1 study evaluating the safety and anti-cancer activity of the small molecule insulin-like growth factor-1 receptor (IGF-1R) inhibitor, linsitinib combined with bortezomib, and dexamethasone in relapsed/refractory multiple myeloma. Nineteen patients were enrolled across four dose-escalation cohorts (75-150 mg bid). The maximum tolerated dose of linsitinib was 125 mg. The most frequent Grade 3/4 AEs occurring in ≥10% of patients were thrombocytopenia (53%), bone pain (26%), neutropenia (21%), diarrhea (14%), anemia (14%), rash (10%), and lung infection (10%). Study discontinuation due to treatment-related AEs was low (16%). Across all cohorts the ORR was 61% (95% CI: 28.9-75.6%). Three partial response or greater and one stable disease were observed in proteasome inhibitor (PI) refractory patients (<i>n</i> = 5). Median PFS was 7.1 months (95% CI: 3.6-NA). Linsitinib plus bortezomib and dexamethasone demonstrate a manageable safety profile while the clinical benefit particularly in PI refractory patients warrants further exploration.
Nuclear Import of Sterol Regulatory Element–binding Protein-2, a Basic Helix-Loop-Helix–Leucine Zipper (bHLH-Zip)–containing Transcription Factor, Occurs through the Direct Interaction of Importin β with HLH-Zip (1999)

The sterol regulatory element-binding protein-2 (SREBP-2) is produced as a large precursor molecule attached to the endoplasmic reticulum membrane. In response to the sterol depletion, the N-terminal segment of the precursor, which contains a basic helix-loop-helix-leucine zipper domain, is released by two sequential cleavages and is translocated to the nucleus, where it activates the transcription of target genes. The data herein show that released SREBP-2 uses a distinct nuclear transport pathway, which is mediated by importin beta. The mature form of SREBP-2 is actively transported into the nucleus when injected into the cell cytoplasm. SREBP-2 binds directly to importin beta in the absence of importin alpha. Ran-GTP but not Ran-GDP causes the dissociation of the SREBP-2-importin beta complex. G19VRan-GTP inhibits the nuclear import of SREBP-2 in living cells. In the permeabilized cell in vitro transport system, nuclear import of SREBP-2 is reconstituted only by importin beta in conjunction with Ran and its interacting protein p10/NTF2. We further demonstrate that the helix-loop-helix-leucine zipper motif of SREBP-2 contains a novel type of nuclear localization signal, which binds directly to importin beta.
ChemInform Abstract: Two‐Dimensional Correlation Spectroscopy by Scalar Couplings: A Walk Through the Periodic Table (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Towards Delay-Tolerant Flexible Data Access Control for Smart Grid with Renewable Energy Resources (2018)

In the Smart Grid with Renewable Energy Resources (RERs), the Residential Units (RUs) with Distributed Energy Resources (DERs) are considered to be both power consumers and suppliers. Specifically, RUs with excessive renewable generations can trade with the utility in deficit of power supplies for mutual benefits. It causes two challenging issues. First, the trading data of RUs is quite sensitive, which should be only accessed by authorized users with fine-grained policies. Second, the behaviors of the RUs to generate trading data are spontaneous and unpredictable, then the problem is how to guarantee system efficiency and delay tolerance simultaneously. In this paper, we propose a delay-tolerant flexible data access control scheme based on Key Policy Attribute Based Encryption (KP-ABE) for Smart Grid with Renewable Energy Resources (RERs). We adopt the secret sharing scheme (SSS) to realize a flexible access control with encryption delay tolerance. Furthermore, there is no central trusted server to perform the encryption/decryption. We reduce the computation cost on RUs and operators via a semi-trusted model. The analysis shows that the proposed scheme can meet the data security requirement of the Smart Grid with RERs, and it also has less cost compared with other popular models.
Supporting access to large digital oral history archives (2002)

This paper describes our experience with the creation, indexing, and provision of access to a very large archive of videotaped oral histories - 116,000 hours of digitized interviews in 32 languages from 52,000 survivors, liberators, rescuers, and witnesses of the Nazi Holocaust. It goes on to identify a set of critical research issues that must be addressed if we are to provide full and detailed access to collections of this size: issues in user requirement studies, automatic speech recognition, automatic classification, segmentation, summarization, retrieval, and user interfaces. The paper ends by inviting others to discuss use of these materials in their own research.
Decoupling Representation and Classifier for Long-Tailed Recognition (2019)

The long-tail distribution of the visual world poses great challenges for deep learning based classification models on how to handle the class imbalance problem. Existing solutions usually involve class-balancing strategies, e.g., by loss re-weighting, data re-sampling, or transfer learning from head- to tail-classes, but most of them adhere to the scheme of jointly learning representations and classifiers. In this work, we decouple the learning procedure into representation learning and classification, and systematically explore how different balancing strategies affect them for long-tailed recognition. The findings are surprising: (1) data imbalance might not be an issue in learning high-quality representations; (2) with representations learned with the simplest instance-balanced (natural) sampling, it is also possible to achieve strong long-tailed recognition ability by adjusting only the classifier. We conduct extensive experiments and set new state-of-the-art performance on common long-tailed benchmarks like ImageNet-LT, Places-LT and iNaturalist, showing that it is possible to outperform carefully designed losses, sampling strategies, even complex modules with memory, by using a straightforward approach that decouples representation and classification. Our code is available at https://github.com/facebookresearch/classifier-balancing.
Solutions to the Hospitality Industry's Labor Shortage (1991)

A shortage of labor exists in the hospitality industry, even to the point that many vacant positions go unfilled. The author discusses some solutions to the problem, including a look at retirees, working mothers, and the disabled.
Proteomic and transcriptomic profiling of Pten gene‐knockout mouse model of prostate cancer (2020)

Our work identified prominent macromolecular signatures and key nodal molecules that help to illuminate the patho- and immunobiology of Pten-loss driven prostate cancer and can facilitate the choice of biomarkers for chemoprevention and interception studies in this clinically relevant mouse prostate cancer model.
RES-701-1,a novel and selective endothelin type B receptor antagonist produced by Streptomyces sp. RE-701. I. Characterization of producing strain, fermentation, isolation, physico-chemical and biological properties. (1994)

RES-701-1, a novel cyclic peptide endothelin antagonist, was isolated from the culture broth of Streptomyces sp. RE-701. RES-701-1 selectively inhibited the ET-1 binding to type B endothelin receptor (ETB receptor) with an IC50 of 10 nM expressed in CHO cells and blocked the ET-1-induced elevation of intracellular free Ca2+ concentration in ETB receptor-expressing COS-7 cells. Characterization of producing strain, fermentation, isolation, structure, physico-chemical and biological properties of RES-701-1 are described.
Evaluation of Direct Detection of Mycobacterium tuberculosis Rifampin Resistance by a Nitrate Reductase Assay Applied to Sputum Samples in Cotonou, Benin (2007)

The aim of this study was to evaluate a nitrate reductase assay (NRA) performed on smear-positive sputa for the direct detection of rifampin resistance in Mycobacterium tuberculosis. A total of 213 smear-positive sputa with a positivity score of 1+ or more (>1 acid-fast bacillus per field by fluorescence microscopy) were used in the study. The samples were decontaminated using the modified Petroff method, and portions of the resulting suspension were used to perform the NRA. The NRA results were compared with the reference indirect proportion method for 177 specimens for which comparable results were available. NRA results were obtained at day 10 for 15 specimens (9%), results for 88 specimens (50%) were obtained at day 14, results for 66 specimens (37%) were obtained at day 18, and results for the remaining 8 specimens (4%) were obtained at day 28. Thus, 96% of NRA results were obtained in 18 days. Of the 177 specimens, there was only one discrepancy (susceptible according to the NRA and resistant according to the indirect proportion method). NRA is simple to perform and provides a rapid, accurate, and cost-effective means for the detection of rifampin resistance in M. tuberculosis isolates.
Studies of Aromatic Redox Shuttle Additives for LiFePO[sub 4]-Based Li-Ion Cells (2005)

Fifty eight aromatic organic molecules were screened as chemical shuttles to provide overcharge protection for /graphite and Li-ion cells. The majority of the molecules were based on methoxybenzene and on dimethoxybenzene with a variety of ligands added to explore their effect. The added ligands affect the redox potential of the molecules through their electron-withdrawing effect and affect the stability of the radical cation. Of all the molecules tested, only 2,5-di-tert-butyl-1,4-dimethoxybenzene shows an appropriate redox potential of vs and long-term stability during extended abusive overcharge totaling over of 100% overcharge per cycle. The reasons for the success of this molecule are explored.
The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters (2022)

As novel SARS-CoV-2 variants continue to emerge, it is critical that their potential to cause severe disease and evade vaccine-induced immunity is rapidly assessed in humans and studied in animal models. In early January 2021, a novel SARS-CoV-2 variant designated B.1.429 comprising 2 lineages, B.1.427 and B.1.429, was originally detected in California (CA) and it was shown to have enhanced infectivity in vitro and decreased antibody neutralization by plasma from convalescent patients and vaccine recipients. Here we examine the virulence, transmissibility, and susceptibility to pre-existing immunity for B 1.427 and B 1.429 in the Syrian hamster model. We find that both variants exhibit enhanced virulence as measured by increased body weight loss compared to hamsters infected with ancestral B.1 (614G), with B.1.429 causing the most marked body weight loss among the 3 variants. Faster dissemination from airways to parenchyma and more severe lung pathology at both early and late stages were also observed with B.1.429 infections relative to B.1. (614G) and B.1.427 infections. In addition, subgenomic viral RNA (sgRNA) levels were highest in oral swabs of hamsters infected with B.1.429, however sgRNA levels in lungs were similar in all three variants. This demonstrates that B.1.429 replicates to higher levels than ancestral B.1 (614G) or B.1.427 in the oropharynx but not in the lungs. In multi-virus in-vivo competition experiments, we found that B.1. (614G), epsilon (B.1.427/B.1.429) and gamma (P.1) dramatically outcompete alpha (B.1.1.7), beta (B.1.351) and zeta (P.2) in the lungs. In the nasal cavity, B.1. (614G), gamma, and epsilon dominate, but the highly infectious alpha variant also maintains a moderate size niche. We did not observe significant differences in airborne transmission efficiency among the B.1.427, B.1.429 and ancestral B.1 (614G) and WA-1 variants in hamsters. These results demonstrate enhanced virulence and high relative oropharyngeal replication of the epsilon (B.1.427/B.1.429) variant in Syrian hamsters compared to an ancestral B.1 (614G) variant.
The changing face of malignant melanoma (2010)

Even though there is an epidemic of malignant melanoma occurring in the United States, it appears that patients are being diagnosed earlier with thinner lesions that are capable of being cured with simple surgical techniques.
Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct (2012)

The strategy described here to generate an artificial polycistronic transcript to inhibit viral replication provided an opportunity to select and optimize many factors to yield highly efficient constructs expressing multiple siRNAs against viral infection.
Atomic-Resolution STEM Imaging of Graphene at Low Voltage of 30 kV with Resolution Enhancement by Using Large Convergence Angle (2015)

Atomic resolution at a low accelerating voltage with aberration correction is required to reduce the electron irradiation damage in scanning transmission electron microscopy imaging. However, the reduction in resolution caused by the diffraction limit becomes severe with increasing electron wavelength at low accelerating voltages. The developed aberration corrector can compensate for higher-order aberration in scanning transmission electron microscopy to expand the uniform phase angle. The resolution for imaging graphene at 30 kV is evaluated by changing the convergence angle for a probe-forming system with a higher-order aberration corrector. A single-carbon atom on graphene is successfully imaged at atomic resolution with a cold-field emission gun by dark-field imaging at an accelerating voltage of 30 kV.
Activation of long chain fatty acids by subcellular fractions of rat liver: II. Effect of ethylenic bond position on acyl‐CoA formation oftrans‐octadecenoates (1973)

Abstract The rates of acyl‐CoA biosynthesis of the trans Δ 4 to Δ 15 octadecenoates have been studied using rat liver microsomes and mitochondria as the enzyme(s) source. Acyl‐CoA formation was lowest when the Δ 9 isomer was the substrate and increased as the double bond was moved to either end of the fatty acid chain. Maximal activation was observed when the Δ 6 and Δ 14 trans ‐octadecenoates were substrates. All‐ trans retinoate caused differential inhibition in the activation rates of the various trans ‐octadecenoate isomers. In contrast, the activation profile relative to double bond position was not altered by changing the incubation temperature, pH, or buffer or by adding fatty acid free albumin to the incubation medium or by aging the enzyme. These results do not support the suggestion that more than one enzyme activates the various trans ‐octadecenoate positional isomers. Triton X‐100 differentially activated acyl‐CoA biosynthesis of the various isomers resulting in a uniform rate of activation. Release of the isomers from the detergent micelle is suggested to be rate‐limiting under these conditions.