gebhart/patrepeval huggingface dataset:
Enhanced Artemin/GFRα3 Levels Regulate Mechanically Insensitive, Heat-Sensitive C-Fiber Recruitment after Axotomy and Regeneration (2010)

We have shown recently that following saphenous nerve transection and successful regeneration, cutaneous polymodal nociceptors (CPMs) lacking transient receptor potential vanilloid 1 (TRPV1) are sensitized to heat stimuli and that mechanically insensitive, heat-sensitive C-fibers (CHs) that contain TRPV1 increase in prevalence. Target-derived neurotrophic factor levels were also enhanced after axotomy and regeneration. In particular, the glial-cell line-derived neurotrophic factor (GDNF) family member artemin was found to be significantly enhanced in the hairy hindpaw skin and its receptor GDNF family receptor α3 (GFRα3) was increased in the L2/L3 dorsal root ganglia (DRGs) following nerve injury. In this study, we assessed the role of enhanced artemin/GFRα3 levels on the changes in mouse cutaneous CH neurons following saphenous nerve regeneration. We used a newly developed siRNA-mediated in vivo knockdown strategy to specifically inhibit the injury-induced expression of GFRα3 and coupled this with an ex vivo recording preparation to examine response characteristics and neurochemical phenotype of different types of functionally defined neurons after injury. We found that inhibition of GFRα3 did not affect the axotomy-induced decrease in CPM threshold, but transiently prevented the recruitment of CH neurons. Western blot and real-time PCR analysis of hairy hindpaw skin and L2/L3 DRGs after saphenous nerve regeneration suggested that inhibition of the potential initial injury-induced increase in enhanced target-derived artemin signaling resulted in dynamic changes in TRPV1 expression after regeneration. These changes in TRPV1 expression may underlie the functional alterations observed in CH neurons after nerve regeneration.
The risk of hyponatremia in older adults using desmopressin for nocturia: A systematic review and meta‐analysis (2004)

Hyponatremia is a relatively common adverse effect of the use of desmopressin for the treatment of nocturia and caution and regular monitoring should be part of the use of this management option for nocturia in older adults.
Novel DSA Scheme that Uses Traffic Characteristics to Enhance Throughput Performance of Wide Area Ubiquitous Wireless Networks (2008)

Wide area ubiquitous wireless networks, which consist of access points (APs) connected to the fixed network and a great many wireless terminals (WTs), can offer a wide range of applications everywhere. In order to enhance network performance, we need to collect different kinds of data from as many WTs as possible; each AP must be capable of accommodating more than 103 WTs. This requirement can be achieved by employing DSA, a typical centralized media access control scheme, since it has high resource utilization efficiency. In this paper, we propose a novel DSA scheme that employs three new techniques to enhance throughput performance; (1) considering that most terminals tend to send data periodically, it employs both polling-based schemes, i.e. request-polling and data-polling, and a random access scheme. (2) In order to enhance bandwidth utilization effectiveness by polling, the polling timing is decided according to the data generation timing. (3) The AP decides the polled data size according to the latest distribution of data size and polls the WT for the data directly. If the data-polling size can not be determined with confidence, the AP uses request-polling instead of data-polling. Simulations verify that the proposed scheme offers better transmission performance than the existing schemes.
Fbxo45 Forms a Novel Ubiquitin Ligase Complex and Is Required for Neuronal Development (2009)

Fbxo45 is an F-box protein that is restricted to the nervous system. Unlike other F-box proteins, Fbxo45 was found not to form an SCF complex as a result of an amino acid substitution in the consensus sequence for Cul1 binding. Proteomics analysis revealed that Fbxo45 specifically associates with PAM (protein associated with Myc), a RING finger-type ubiquitin ligase. Mice deficient in Fbxo45 were generated and found to die soon after birth as a result of respiratory distress. Fbxo45(-)(/)(-) embryos show abnormal innervation of the diaphragm, impaired synapse formation at neuromuscular junctions, and aberrant development of axon fiber tracts in the brain. Similar defects are also observed in mice lacking Phr1 (mouse ortholog of PAM), suggesting that Fbxo45 and Phr1 function in the same pathway. In addition, neuronal migration was impaired in Fbxo45(-)(/)(-) mice. These results suggest that Fbxo45 forms a novel Fbxo45-PAM ubiquitin ligase complex that plays an important role in neural development.
Formation of Surface Oxygen Species and the Conversion of Methane to Value-Added Products with N2O as Oxidant over Fe-Ferrierite Catalysts (2019)

Formation of active oxygen species from N2O over Fe-ferrierite (Fe-FER) catalyst prepared by solid-state ion-exchange method at moderate temperatures was studied using spectroscopic and solid characterization techniques including H2 temperature-programmed reduction (H2-TPR), N2O temperature-programmed desorption (N2O-TPD), and in situ Fourier transform infrared (FTIR). The utilization of active oxygen species for the direct conversion of methane to value-added products at moderate temperatures was investigated. The active oxygen sites for the selective conversion of methane were identified by a TPR feature at 220 °C. This site is also characterized by an infrared band observed at 1872 and 1892 cm–1 upon adsorption of NO. These bands are NO stretching vibrations of NO adsorbed on iron oxygen monomeric species, present in the zeolite cages and responsible for selective oxidation. We show that these oxidized species react with methane to form oxygenates but at higher temperatures form molecular oxygen. IR bands of surface methoxy groups were observed in significant concentration in the FTIR spectra and are suggested to be intermediate species of the selective oxidation of methane. Studies using continuous reactors demonstrated that cofeeding of methane and N2O-promoted generation of desired products from methane conversion by N2O over Fe-FER catalyst can be enhanced by optimizing the feed ratio of CH4/N2O. Furthermore, N2, O2 and NO were detected as the products of N2O decomposition over Fe-FER catalysts.
Fuzzy Set Methods for Object Recognition in Space Applications (1991)

During the reporting period, the development of the theory and application of methodologies for decision making under uncertainty was addressed. Two subreports are included; the first on properties of general hybrid operators, while the second considers some new research on generalized threshold logic units. In the first part, the properties of the additive gamma-model, where the intersection part is first considered to be the product of the input values and the union part is obtained by an extension of De Morgan's law to fuzzy sets, is explored. Then the Yager's class of union and intersection is used in the additive gamma-model. The inputs are weighted to some power that represents their importance and thus their contribution to the compensation process. In the second part, the extension of binary logic synthesis methods to multiple valued logic synthesis methods to enable the synthesis of decision networks when the input/output variables are not binary is discussed.
Wideband beamforming using fan filter (2003)

A novel approach to wideband beamforming using FIR (finite impulse response) fan filters is presented. The method is based on two-dimensional filtering for the outputs of a linear array of sensors. To beamform in the broadside of the array, a symmetrical 90 degrees /n filter is employed. The filter in which the angle of fan is more acute can form the narrower beam over the full band while the order of the filter becomes higher. To beamform in the direction along the array, an asymmetrical 45 degrees fan filter is used. As aliasing occurs in this beamforming, the band which is available is limited a little in width. A general implementation of the FIR fan filter beamformer is given as the parallel connection of one-dimensional FIR filters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Sequence-independent activation of photocycloadditions using two colours of light (2021)

We exploit two reactive chromophores to establish sequence-independent photochemical activation, employing <i>ortho</i>-methyl benzaldehyde (<i>o</i>MBA) and <i>N</i>,<i>N</i>-(dimethylamino)pyrene aryl tetrazole (APAT) with <i>N</i>-(2-hydroxy)ethyl maleimide (<i>N</i>HEM), without any additives. Critically, the order of the irradiation sequence is irrelevant, as the shorter wavelength does not activate the higher wavelength activated species. Therefore, full sequence-independent λ-orthogonality is achieved through differences in both the reaction quantum yields (<i>Φ</i> <sub>r,<i>o</i>MBA</sub> and <i>Φ</i> <sub>r,APAT</sub>) and wavelength-dependent reactivity profiles of the employed chromophores.
Observation and Simulation of the Development of Equatorial Plasma Bubbles: Post‐Sunset Rise or Upwelling Growth? (2020)

Abstract This study investigates the underlying physics of equatorial plasma bubbles (EPBs) on 11 December 2019, under solar minimum conditions. The Global‐scale Observations of the Limb and Disk (GOLD) ultraviolet nightglow images exhibit a periodic distribution of reduced emissions related to EPBs. Remarkably, FORMOSAT‐7/COSMIC‐2 (F7/C2) observes a significant altitudinal difference of ~45 km in the bottomside ionosphere between two nearly collocated electron density profiles before the onset of EPBs, indicating the presence of an upwelling. Distinct ionospheric perturbations are also observed in F7/C2 and ground‐based Global Positioning System observations, suggesting that gravity waves may contribute to the upwelling. Simulations with SAMI3/ESF are further carried out to evaluate the upwelling growth and pre‐reversal enhancement (PRE) effect on EPB development. Simulations reveal that the crests of upwellings show a localized uplift of ~50 km, and EPBs only develop from the crest of upwellings. The uplift altitude of upwellings is comparable to the F7/C2 observations and the post‐sunset rise in moderate solar conditions. The polarization electric field ( E p ) developed within the upwellings can drive vertical E p × B drifts of ~32–35 m/s, which are comparable to the PRE vertical E × B drifts. We find that the PRE alone cannot drive EPBs without upwelling growth, but it can facilitate the upwelling growth. Observations and simulations allow us to conclude that upwelling growth could play a vital role in the formation of EPBs.
CO MULTIPHOTON DISSOCIATIVE IONIZATION THROUGH B$^1\Sigma^+$ STATE (2005)

Author Institution: Department of Chemistry, Wayne State University, Detroit, MI 48317 (email to W.L.: wenli2@ic.sunysb.edu)
Prediction of spinodal wavelength in continuously cooled metallic liquid (2009)

The spinodal decomposition of a deeply undercooled metallic liquid Zr(41.2) Ti(13.8)Cu(12.5)Ni(10)Be(22.5) between 800 and 700 K is analysed in the framework of the theory of Cahn and Hilliard for continuous cooling, and the wavelength with maximum amplification is predicted, using as input parameters thermodynamic values gained in experiments. Electron microscopical studies show the microstructure of glass forming alloys Zr(41.2)Ti(13.8)Cu(12.5)Ni(10)Be(22.5). The as-cast material exhibits a two phase mixture of amorphous regions with different compositions. Evidence for spinodal decomposition is given, and the Computed maximum-amplitude wavelength corresponds well with the one found in the experiments. (C) 2009 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim
Nanosecond four-wave mixing and holography in BSO crystals (1981)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. P. Hermann, J. P. Herriau, and J. P. Huignard, "Nanosecond four-wave mixing and holography in BSO crystals," Appl. Opt. 20, 2173-2175 (1981) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Theoretical study of strain-dependent optical absorption in a doped self-assembled InAs/InGaAs/GaAs/AlGaAs quantum dot (2018)

A detailed theoretical study of the optical absorption in doped self-assembled quantum dots is presented. A rigorous atomistic strain model as well as a sophisticated 20-band tight-binding model are used to ensure accurate prediction of the single particle states in these devices. We also show that for doped quantum dots, many-particle configuration interaction is also critical to accurately capture the optical transitions of the system. The sophisticated models presented in this work reproduce the experimental results for both undoped and doped quantum dot systems. The effects of alloy mole fraction of the strain controlling layer and quantum dot dimensions are discussed. Increasing the mole fraction of the strain controlling layer leads to a lower energy gap and a larger absorption wavelength. Surprisingly, the absorption wavelength is highly sensitive to the changes in the diameter, but almost insensitive to the changes in dot height. This behavior is explained by a detailed sensitivity analysis of different factors affecting the optical transition energy.
Novel low-kVp beamlet system for choroidal melanoma (2006)

The BLOKX technique allows more favorable dose distribution in comparison to standard COMS brachytherapy, as simulated using a Monte Carlo iterative mathematical modeling. Future series to determine clinical utility of such an approach are warranted.
Improved Bulletin Generation Using an Iterative Processing Framework (2015)

Abstract not provided.
A reappraisal of evidence for probabilistic models of allelic exclusion (2008)

B cell development requires the coordinated rearrangement of Ig heavy (IgH) and light chain loci (IgL). Most mature B cells express a single B cell receptor of unique specificity, and a central question in immunology concerns the mechanisms that prevent the productive rearrangement of >1 IgH and IgL allele per cell. Probabilistic models of allelic exclusion maintain that simultaneous rearrangement of both alleles is rare, because the likelihood of undergoing rearrangement is low for a given Ig allele. Strong support for this idea came from studies in which a GFP marker was inserted into the Igk locus. In this system, the probability of high-level germ-line transcription and subsequent locus rearrangement appeared to be low in pre-B cells. Readdressing the validity of GFP expression as a reporter for the level of germ-line transcription, we found a striking discordance between GFP transcript and protein levels at the pre-B cell stage, which is explained at least in part by the developmentally regulated usage of 2 alternative Igk-J germ-line promoters. These results question the validity of the kappa-GFP system as evidence for probabilistic models of allelic exclusion.
Robustness of Residual Network in Predicting PR Interval Trained using Noisy Labels (2022)

The PR interval represents the time required from the electrical impulse to advance from the atrium to AV node and His-Purkinje system until the ventricular myocardium begins to depolarize.PR interval prolongation has been associated with significant increases in atrial fibrillation, heart failure and mortality.Over the past years, multiple deep learning models have been proposed to interpret electrocardiogram (ECG) signals.Despite initial success, these models are often trained and validated using datasets that contain partially incorrect labels.These "noisy" labels exist because of the way the annotated data was collected and pose challenges for model training and validation.As a result, a residual neural network (ResNet), trained on noisy data, was proposed to estimate PR intervals.In addition, an electrophysiologist performed a blinded manual adjudication on a stratified sample to validate the accuracy of both the model and the noisy labels.The conclusion is that a ResNet trained on noisy data can correctly estimate PR intervals and outperforms the noisy labels it was trained on.
Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats (2020)

The heptapeptide angiotensin-(1-7) (Ang-(1-7)) is protective in the cardiovascular system through its induction of vasodilator production and angiogenesis. Despite acting antagonistically to the effects of elevated, pathophysiological levels of angiotensin II (AngII), recent evidence has identified convergent and beneficial effects of low levels of both Ang-(1-7) and AngII. Previous work identified the AngII receptor type I (AT1R) as a component of the protein complex formed when Ang-(1-7) binds its receptor, Mas1. Importantly, pharmacological blockade of AT1R did not alter the effects of Ang-(1-7). Here, we use a novel mutation of AT1RA in the Dahl salt-sensitive (SS) rat to test the hypothesis that interaction between Mas1 and AT1R contributes to proangiogenic Ang-(1-7) signaling. In a model of hind limb angiogenesis induced by electrical stimulation, we find that the restoration of skeletal muscle angiogenesis in SS rats by Ang-(1-7) infusion is impaired in AT1RA knockout rats. Enhancement of endothelial cell (EC) tube formation capacity by Ang-(1-7) is similarly blunted in AT1RA mutant ECs. Transcriptional changes elicited by Ang-(1-7) in SS rat ECs are altered in AT1RA mutant ECs, and tandem mass spectrometry-based proteomics demonstrate that the protein complex formed upon binding of Ang-(1-7) to Mas1 is altered in AT1RA mutant ECs. Together, these data support the hypothesis that interaction between AT1R and Mas1 contributes to proangiogenic Ang-(1-7) signaling.
Computer reactivity requirement and control rod worth for 30 MW, 2-day operation of PBF with a large reactive experiment (1976)

Reactor physics calculations have been performed to investigate the feasibility of conducting loss of coolant (LOCA) experiments that will require steady state operation with the present Power Burst Facility (PBF) reactor core configuration. It was determined that sufficient excess reactivity would be available for 48 hour irradiation of a 16-pin LOCA test cluster at a PBF core power of 30 MW. It was also determined that shutdown requirements could be met with the LOCA test in place and that no additional reactivity shimming would be necessary. A description of these calculations is given.
Organotemplate-free and seed-directed synthesis of ZSM-34 zeolite with good performance in methanol-to-olefins (2012)

The methanol-to-olefins (MTO) reaction over zeolites is of great importance due to the shortage of crude oil, and we demonstrate here a fast, organotemplate-free, and seed-directed synthesis of ZSM-34 zeolite, designated as ZSM-34-S, having very high selectivity for propylene. When the temperature is at 140–180 °C, ZSM-34-S zeolite could be crystallized for 2–6 h in the presence of ZSM-34 crystals as seeds. For industry, a fast and organotemplate-free synthesis, a typically green route, means significant savings in energy and costs. Characterizations using XRD, SEM, 27Al and 29Si MAS NMR, and N2 sorption techniques show that the ZSM-34-S crystals grow from the seeds of ZSM-34 crystals in an amorphous aluminosilicate. Catalytic tests of the MTO reaction show that HZSM-34-S has a very high selectivity for propylene (55.2%), which is even higher than that (47.0%) of SAPO-34 under the same conditions. Moreover, the hydrothermal treatment of HZSM-34-S significantly improves the catalyst life for MTO due to decreasing acidic concentration and increasing anti-deactivation. The combination of a “green” synthesis and the good catalytic performance of ZSM-34-S would be potentially important for the highly effective conversion of methanol, which can be easily obtained from coal, natural gas, or biomass at a large scale.
Absorbance Studies of Perovskite CH<sub>3</sub>NH<sub>3</sub>PbI<sub>(3-x)</sub>Cl<sub>x</sub> as Light Harvester in Solar Cell (2015)

Hybrid perovskite is one of the emerging materials which is currently being widely investigated for solar cells. Here we report the synthesis and characterization of perovskite compound which can be used as a light harvester in photovoltaic cells, which is CH 3 NH 3 PbI (3-x) Cl x . The perovskite materials were synthesized using solution-based methods. Several parameters are investigated in the synthesis of CH 3 NH 3 PbI (3-x) Cl x perovskite, which are the influence of precursor composition, synthesis temperature , precursor concentration, and the annealing temperature. These parameters are optimized against the absorbance and bandgap of the synthesized CH 3 NH 3 PbI (3-x) Cl x thin film. The optimized perovskite thin film is obtained with excellent absorption capabilities for solar cell applications.
Application-specific customisation of multi-threaded soft processors (2006)

A multi-threaded microprocessor with a customisable instruction set, CUStomisable Threaded ARchitecture (CUSTARD), is proposed. CUSTARD features include design space exploration and a compiler for automatic selection of custom instructions. Custom instructions, optimised for a specific application, accelerate frequently performed computations by implementing them as dedicated hardware. Field programmable gate array implementations of CUSTARD are evaluated using media and cryptography benchmarks, and commercial MicroBlaze processor is compared. As low as 28% area overhead for four interleaved threads and up to 355% speedup over a processor without custom instructions are demonstrated.
ELECTRON BEAM MICROANALYSIS OF CARBONS. I. X-RAY INTENSITIES OF C- K$alpha$-LINE. (1972)

Systemic lupus erythematosus (SLE) is one of the most heterogeneous autoimmune disorders known. There is production of a variety of autoantibodies and patients present with a wide range of symptoms due to multiple organ involvement by the disease process. The underlying cause is not fully understood but it may involve genetic and environmental factors. It is interesting to note that while SLE is found worldwide, it is more commonly found in some countries, and within a country certain ethnic groups appear to be more susceptible to develop this condition than others. Additionally, the presentation and course of SLE appear highly variable between patients of different ethnic origins. For example, African-Americans and Orientals are believed to have a more severe disease than Caucasian whites. But are these ethnic and geographical differences real? If yes, they may provide investigators insight into the underlying pathoaetiology of this condition and pave the way to future research directions in lupus.