gebhart/patrepeval huggingface dataset:
<title>Silicon CMOS-based vertical multimode interference optical taps</title> (2001)

A compact, low loss, optical tap technology is critical for the incorporation of optical interconnects into mainstream CMOS processes. A recently introduced multimode interference effect based device has the potential for very high speed performance in a compact geometry and in a CMOS compatible process. For this work, 2-D and 3-D device simulations confirm a low excess optical loss on order of 0.1 dB, and a nominal 40% (2.2 dB) optical coupling into the CMOS circuitry over a wide range of guide to substrate distances. Simulated devices are on the order of 25micrometers in length and as narrow as 1 um. High temperature, hybrid polymer materials used for commercial CMOS inter-metal dielectric layers are targeted for tap fabrication and are incorporated into the models. Low cost, silicon CMOS based processing makes the new tap technology especially suitable for computer multi-chip module and board level interconnects, as well as for metro fiber to the home and desk telecommunications applications.
Support Vector Machines for Condition Monitoring of Bearings in a Varying-Speed Machinery (2011)

This paper deals with the diagnostics of ball bearings in direct-drive motors by means ofSupport Vector Machines (SVM). For the new generation of packaging machines,direct-drive motors have substituted parts of the mechanical transmission chains asgears train or cams between the motor and the load. In fact, a position feed-back is usedby the control system to perform polynomial profiles of motion involving continuouschanges of the shaft speed and a cyclic inversion of its rotating direction.The presenceof complex shaft dynamics provides a vibration signal extremely noisy, where theevents due to malfunctions or damages disappear and are not periodic, so the classicmethodologies for the monitoring of the support conditions based on the signal analysisin the frequency domain are ineffective. In this paper the use of Support VectorMachines overcomes the constant-speed limits and the SVM are proven to be apowerful and reliable tool to diagnose the health of ball bearing even in variable-speedapplications, based on experimental tests conducted on an industrial packaging machine
Increased Expression of Sodium Transporters in Rats Chronically Inhibited of Nitric Oxide Synthesis (2006)

The present study was done to determine whether endogenous nitric oxide (NO) plays a role in the regulation of sodium transporters in the kidney. Male Sprague-Dawley rats were treated with NG-nitro-L-arginine methyl ester (L-NAME, 100 mg/L drinking water) for 4 weeks. Control rats were supplied with tap water without drugs. Expression of Na, K-ATPase, type 3 Na/H exchanger (NHE3), Na/K/2Cl cotransporter (BSC1), and thiazide-sensitive Na/Cl cotransporter (TSC) proteins was determined in the kidney by Western blot analysis. Catalytic activity of Na,K-ATPase was also determined. The treatment with L-NAME significantly and steadily increased the systemic blood pressure. Total and fractional excretion of urinary sodium decreased significantly, while creatinine clearance remained unaltered. Neither plasma renin activity nor aldosterone concentration was significantly altered. The alpha1 subunit expression and the catalytic activity of Na, K-ATPase were increased in the kidney. The expression of NHE3, BSC1 and TSC was also increased significantly. These results suggest that endogenously-derived NO exerts a tonic inhibitory effect on the expression of sodium transporters, including Na, K-ATPase, NHE3, BSC1, and TSC, in the kidney.
O-030 age-related outcomes following intracranial aneurysm treatment with the pipeline embolization device: a subgroup analysis of the intreped registry (2015)

<h3>Background and purpose</h3> The association between age and outcomes following aneurysm treatment with flow diverters such as the Pipeline Embolization Device (PED) have not been well established. Using the International Retrospective Study of the Pipeline Embolization Device (IntrePED registry, we assessed the age-related clinical outcomes of patients undergoing aneurysm embolization with the PED. <h3>Materials and methods</h3> IntrePED registry unruptured aneurysm patients were divided into four age groups: ≤50, 51–60, 61–70 and. &gt;70 years old. The rates of the following post-operative complications were compared between age groups using chi-squared tests: spontaneous rupture, intracranial hemorrhage, ischemic stroke, parent artery stenosis, cranial neuropathy, neurological morbidity, neurological mortality, combined neurological morbidity and mortality and all-cause mortality. The association between age and these complications was tested in a multivariate logistic regression analysis adjusting for sex, number of PEDs, aneurysm size, location and type. <h3>Results</h3> 711 patients with 820 unruptured aneurysms were included in this study. Univariate analysis demonstrated no significant difference in intracranial hemorrhage rates across age groups (lowest 1.0% for patients≤50 and highest 4.1% for patients &gt;70, P = 0.21). There was no difference in ischemic stroke rates (lowest 3.6% for patients≤50 and highest 6.0% for patients 50–60, P = 0.72). Age &gt;70 years old was associated with higher rates of neurological mortality as patients &gt;70 years old had neurological mortality rates of 7.4% compared to 3.3% for patients 61–70, 2.7% for patients 51–60 and 0.5% for patients≤50 years old (P = 0.006). On multivariate logistic regression analysis, increasing age was associated with a higher odds of combined neurological morbidity and mortality (OR&nbsp;=&nbsp;1.02, 95% CI&nbsp;=&nbsp;1.00–1.05, P = 0.03). <h3>Conclusions</h3> Increasing age is associated with higher neurological morbidity and mortality after Pipeline embolization of intracranial aneurysms. However, the overall complication rates of PED treatment in select elderly patients (&gt;70) were acceptably low suggesting that age alone should not be considered an exclusion criteria when considering treatment of intracranial aneurysms with PED. <h3>Disclosures</h3> W. Brinjikji: None. D. Kallmes: 1; C; Covidien. H. Cloft: None. G. Lanzino: 2; C; Covidien.
Hearing, Emotion, Amplification, Research, and Training Workshop: Current Understanding of Hearing Loss and Emotion Perception and Priorities for Future Research (2018)

The question of how hearing loss and hearing rehabilitation affect patients' momentary emotional experiences is one that has received little attention but has considerable potential to affect patients' psychosocial function. This article is a product from the Hearing, Emotion, Amplification, Research, and Training workshop, which was convened to develop a consensus document describing research on emotion perception relevant for hearing research. This article outlines conceptual frameworks for the investigation of emotion in hearing research; available subjective, objective, neurophysiologic, and peripheral physiologic data acquisition research methods; the effects of age and hearing loss on emotion perception; potential rehabilitation strategies; priorities for future research; and implications for clinical audiologic rehabilitation. More broadly, this article aims to increase awareness about emotion perception research in audiology and to stimulate additional research on the topic.
Microwave Assisted Synthesis of Bridgehead Alkenes (2011)

A new, concise method to synthesize triene precursors for the type 2 intramolecular Diels-Alder reaction has been developed. Microwave irradiation of the trienes provides a convenient method for the synthesis of bridgehead alkenes. Higher yields, shorter reaction times, and lower reaction temperatures provide a general and efficient route to this interesting class of molecules.
A Preliminary Scalability Analysis of SPEC CPU2017 Benchmarks (2021)

The SPEC CPU benchmark suites of compute-intensive benchmarks are widely used for evaluating performance of modern computer systems. Following a shift from single-core to multi-core processors, the latest suites, SPEC CPU2017, include benchmarks that are multi-threaded. This paper explores the scalability of CPU2017 benchmarks by investigating their performance in modern computer systems as a function of the number of threads for speed benchmarks and the number of copies for rate benchmarks. Based on the experimental study conducted on a pair of in-house machines, we categorize benchmarks into groups that `scale-well', `scale-moderately', and `scale-poorly'. In addition, we analyze the publicly available SPEC CPU2017 results to explore scalability trends of individual benchmarks on a wider variety of computer systems. The main findings of the study are as follows: (a) A number of speed multi-threaded benchmarks that use OpenMP saturate after a certain number of threads. The paper provides the maximum speedups and thread count needed to reach saturation. (b) Memory intensive rate benchmarks scale poorly because their demands for shared resources exceed the capacity of modern computer systems. The study aims to inform performance analysts of the limitations of the speed benchmarks in extracting system parallelism and to provide scalability expectations for the rate benchmarks on modern computer systems.
Effects of Aortic Occlusion on Regional Spinal Cord Blood Flow and Somatosensory Evoked Potentials in Sheep (1987)

Somatosensory evoked potentials (SEPs) were recorded continuously during aortic occlusion in sheep, with simultaneous measurement of spinal cord blood flow (SCBF) by radiolabeled microspheres. Aortic occlusion was associated with disappearance of the SEPs in seven of nine sheep in 7.8 +/- 4.1 (SD) minutes. SCBF at the time of initial cross clamping and 30 minutes after the onset of ischemia revealed a severe reduction in white and gray matter flow in the thoracolumbar cord. Release of the aortic clamp was associated with reactive hyperemia in these ischemic regions. In two animals, the SEP persisted during aortic cross clamping. The total SCBF in the thoracic and lumbar regions of these two animals exceeded 20 ml/100 g/min after 30 minutes of ischemia and was significantly greater than the flow recorded in sheep whose evoked response disappeared. The relation between spinal cord ischemia and evoked potential alterations is discussed in detail.
A vibration isolation system using active PZT brackets (2005)

A new type of active isolation system was designed and tested in The Aerospace Corporation's Dynamics and Control Center. This isolation system utilizes PZT actuators bonded on S-shaped brackets. The system exhibits very good isolation performance by attenuating external vibrations to amplitudes less than 1/10 of their original values. This disturbance attenuation performance relies on adequate knowledge of the plant's dynamic characteristics, and therefore, the design depends on a reliable system identification process which was made possible by frequency response analysis using a Hewlett-Packard 3562 analyzer.
Demonstrations on the scattering of sound by bubble clouds (1991)

A bubblemaker (which operates by regulating a transient volume of air stored in a chamber placed between two solenoid valves) is the heart of an experimental apparatus used to generate a transient bubble cloud in water. The apparatus can be adjusted to create a cylindrical bubble column terminating at the air-water interface. Sound pulses are generated by a circular plane array “transmitting” transducer driven by an electronic tone burst generator. Backscattering, at the angle θ = 180°, from the cloud is measured by a receiving transducer. Results are displayed to show any difference measured between scattering by the transient cloud and by the cylindrical column. [Work supported by the Naval Academy Research Council and by the National Center for Physical Acoustics.]
Erratum: A double missense variation of theBUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T (2005)

Certain samples of the cell line Hs766T within our laboratory were contaminated by the cell line RKO in the past. This affected two published papers (Hempen et al., 2002; Sohn et al., 2002, 2003). We recently identified that the reported BUB1 alteration is present in RKO cells and is not present in Hs766T cells. RKO cells are known to have an intact mitotic checkpoint (Cahill et al., 1998). Using current cell lines having identities confirmed by the sequencing of their other known mutant genes, we confirm the finding of a mitotic checkpoint defect among pancreatic cancers having CIN (chromosomal instability): the maximal mitotic index under colcemid (0.1 ug/ml) treatment is 85% for RKO cells (colorectal cancer, MSI, microsatellite instability), 9.4% for Hs766T cells (pancreatic, CIN), 23% for Su86.86 cells (pancreatic, CIN), and 44% for BxPC3 cells (pancreatic, CIN). The reported double missense mutation of the mitotic checkpoint BUB1 gene is thus associated not with a defective mitotic checkpoint in a CIN line as we had reported, but interestingly occurs in an MSI line having an intact checkpoint. The prevalence rate of BUB1 and other mitotic checkpoint gene mutations in MSI cell lines has not yet been reported. Presumably, BUB1 missense mutations do not always create a significant functional defect. © 2005 Wiley-Liss, Inc.
Correlation between Thermal Radiosensitization and Slowly Rejoined DNA Strand Breaks in CHO Cells (1995)

The effect on the repair of slowly rejoined strand breaks was studied in CHO cells using the alkaline unwinding technique. Heat (45 degrees C, 20 min) combined with a X-ray dose of 9 Gy was found to result in an increased half-time of repair but also in an increased number of slowly rejoined strand breaks. When a time interval at 37 degrees C was inserted between irradiation and heat, the half-time of repair was not altered, whereas the number of slowly rejoined strand breaks as measured 300 min after irradiation decreased with increasing time interval between the two treatments. The half-time of 18 +/- 2 min suggested that the additionally formed, slowly rejoined strand breaks arise from a certain type of radiation-induced DNA base lesions with repair of which is modified by heat. The effect of X-irradiation combined with heat was also studied for cell survival. When irradiation and heat were separated by an incubation at 37 degrees C, cell survival increased with a half-time of 20 +/- 2 min, which is similar to that measured for the number of additional, slowly rejoined strand breaks. For a great variety of combined treatments, the reduction in cell survival correlates well with the enhanced number of slowly rejoined strand breaks measured 300 min after irradiation. This positive correlation and the similarity in the half-times mentioned above suggests that thermal radiosensitization results from the number of additional, slowly rejoined strand breaks formed when irradiation was combined with heat.
Oncogene Coexpression in Mesenchymal Neoplasia Correlates with EGF Transcription (2007)

Epidermal growth factor (EGF) is a potent mitogenic factor for cells of mesodermal and ectodermal origin, and its over-expression is associated with a variety of cancers. We asked whether oncogene coexpression occurs in mesenchymal neoplasms, if coexpression correlates with EGF transcription, and whether coexpression can be attributed to the EGF-induced overexpression of oncogenes. We quantified the mRNA concentrations of EGF and 14 oncogenes in 42 primary sarcomas, 31 benign tumors, and 10 skeletal muscle controls, and compared mRNA concentrations and gene pair correlations in EGF positive (EGF+) tumors to transcript concentrations and correlations in EGF negative (EGF-) tumors. Transcripts were detected by real time reverse transcription-polymerase chain reaction. Pearson's correlation coefficients identified gene associations, and gene synchrony associated with EGF expression was evaluated using chi square. Transcript concentrations in tumors were compared graphically and with t tests. Gene correlations predominated in EGF+ benign tumors and in EGF- primary sarcomas. The dichotomy in oncogene coexpression evident in benign and malignant tumors could not be attributed to statistical differences in mRNA content between EGF+ and EGF- tumors. EGF may enhance, or may indicate the presence of, oncogene coexpression in benign mesenchymal lesions, but counters gene synchronization in sarcomas.
Ribosome Synthesis-Unrelated Functions of the Preribosomal Factor Rrp12 in Cell Cycle Progression and the DNA Damage Response (2011)

Given the high metabolic cost required to generate ribosomes, it has been assumed that proteins involved in ribosome synthesis might establish functional cross talk with other intracellular processes to efficiently couple ribosome production and cell growth. However, such interconnections have remained elusive due to the difficulty in separating the intra- and extraribosomal roles of ribosome biogenesis factors. Using a yeast functional screen, I have discovered that Rrp12, a conserved protein involved in ribosome maturation and export, plays roles in the cell cycle and the DNA damage response. These results indicate that Rrp12 participates in a karyopherin Kap121-dependent import route that is crucial for nuclear sequestration of ribonucleotide reductase subunits and, thereby, ensures the proper kinetics of deoxyribonucleotide production during the cell cycle. Within this route, Rrp12 acts as a cofactor important for the full functionality of Kap121. This activity is mechanistically different from the known roles of Rrp12 in ribosome biogenesis. I propose that the functional duality of Rrp12 may couple the control of ribosome production to the regulation of other cellular processes during cell cycle progression.
Neighborhood search methods with Moth Optimization algorithm as a wrapper method for feature selection problems (2020)

Feature selection methods are used to select a subset of features from data, therefore only the useful information can be mined from the samples to get better accuracy and improves the computational efficiency of the learning model. Moth-flam Optimization (MFO) algorithm is a population-based approach, that simulates the behavior of real moth in nature, one drawback of the MFO algorithm is that the solutions move toward the best solution, and it easily can be stuck in local optima as we investigated in this paper, therefore, we proposed a MFO Algorithm combined with a neighborhood search method for feature selection problems, in order to avoid the MFO algorithm getting trapped in a local optima, and helps in avoiding the premature convergence, the neighborhood search method is applied after a predefined number of unimproved iterations (the number of tries fail to improve the current solution). As a result, the proposed algorithm shows good performance when compared with the original MFO algorithm and with state-of-the-art approaches.
A System for Collecting and Mapping Traffic Congestion in a Network Using GPS Smartphones from Regular Drivers (2015)

This paper presents an update on the current development of a smartphone-based system for collecting and analyzing route global positioning system (GPS) data coming from regular driver routes. Using GPS functionality on Android and iOS smartphones to log route data, a large database containing thousands of trips was collected in a short period of time after a mass-media campaign in Quebec City. As part of the system, a platform was built for mapping traffic congestion using the average speed and speed differential at the link level. The system includes a number of components: i) a smartphone application, ii) a server-platform to receive and display raw data, and iii) an analytics platform to compute and display different link-level speed (or travel time) measures with interactive maps. As a result of the smartphone GPS data collection method, a large dataset of information was generated from more than 30,000 trips collected in 3 weeks and more than 4,000 drivers emitting trips on a voluntary basis. The results demonstrate the feasibility and promising potential of the data collection system that can be implemented in any city and sets the ground for real-time applications.
A Molecular Dynamics Study of Crosslinked Phthalonitrile Polymers: The Effect of Crosslink Density on Thermomechanical and Dielectric Properties (2018)

In this work, molecular dynamics (MD) and molecular mechanics (MM) simulations are used to study well-equilibrated models of 4,4'-bis(3,4-dicyanophenoxy)biphenyl (BPh)⁻1,3-bis(3-aminophenoxy)benzene (m-APB) phthalonitrile (PN) system with a range of crosslink densities. A cross-linking technique is introduced to build a series of systems with different crosslink densities; several key properties of this material, including thermal expansion, mechanical properties and dielectric properties are studied and compared with experimental results. It is found that the coefficient of linear thermal expansion predicted by the model is in good agreement with experimental results and indicative of the good thermal stability of the PN polymeric system. The simulation also shows that this polymer has excellent mechanical property, whose strength increases with increasing crosslink density. Lastly and most importantly, the calculated dielectric constant-which shows that this polymer is an excellent insulating material-indicates that there is an inverse relation between cross-linking density and dielectric constant. The trend gave rise to an empirical quadratic function which can be used to predict the limits of attainable dielectric constant for highly crosslinked polymer systems. The current computational work provides strong evidence that this polymer is a promising material for aerospace applications and offers guidance for experimental studies of the effect of cross-linking density on the thermal, mechanical and dielectric properties of the material.
Solvent-controlled acceleration of electron transfer reaction (2000)

Liquid phase electron transfer is one of the key reactions in nature and has been extensively studied. Previously, electron transfer (ET) was modelled as thermally activated barrier hopping. Subsequent improvements of the theory that incorporated the influence of solvent dynamics on the ET process, led to the central conclusion that the inverse ET rate is linearly proportional to the longitudinal relaxation time of the solvent. We present the first, to the best of our knowledge, experimental evidence of the solvent-controlled rate of the intermolecular ET reaction. The key virtue of the study is the use of binary mixtures, which allows us to vary continuously the relaxation properties of the solvent. We demonstrate that the ET reaction rate can be increased by more than a factor of 5, which signifies the change from solvent-controlled ET to a non-adiabatic ET.
Spatial constrained inverse rock physics modelling (2014)

ABSTRACT Predicting reservoir parameters, such as porosity, lithology, and saturations, from geophysical parameters is a problem with non‐unique solutions. The variance in solutions can be extensive, especially for saturation and lithology. However, the reservoir parameters will typically vary smoothly within certain zones—in vertical and horizontal directions. In this work, we integrate spatial correlations in the predicted parameters to constrain the range of predicted solutions from a particular type of inverse rock physics modelling method. Our analysis is based on well‐log data from the Glitne field, where vertical correlations with depth are expected. It was found that the reservoir parameters with the shortest depth correlation (lithology and saturation) provided the strongest constraint to the set of solutions. In addition, due to the interdependence between the reservoir parameters, constraining the predictions by the spatial correlation of one parameter also reduced the number of predictions of the other two parameters. Moreover, the use of additional constraints such as measured log data at specific depth locations can further narrow the range of solutions.