gebhart/patrepeval huggingface dataset:
Epiphany: A location hiding architecture for protecting critical services from DDoS attacks (2012)

Critical services operating over the Internet are increasingly threatened by Distributed Denial of Service (DDoS) attacks. To protect them we propose Epiphany, an architecture that hides the service IP addresses so that attackers cannot locate and target them. Epiphany provides service access through numerous lightweight proxies, presenting a wide target to the attacker. Epiphany has strong location hiding properties; no proxy knows the service address. Instead, proxies communicate over ephemeral paths controlled by the service. If a specific proxy misbehaves or is attacked it can be promptly removed. Epiphany separates proxies into setup and data, and only makes setup proxies public, but these use anycast to create distinct network regions. Clients in clean networks are not affected by attackers in other networks. Data proxies are assigned to clients based on their trust. We evaluate the defense properties of Epiphany using simulations and implementations on PlanetLab and a router testbed.
Messenger RNA capture sequencing of extracellular RNA from human biofluids using a comprehensive set of spike-in controls (2021)

Comprehensive transcriptome analysis of extracellular RNA (exRNA) purified from human biofluids is challenging because of the low RNA concentration and compromised RNA integrity. Here, we describe an optimized workflow to (1) isolate exRNA from different types of biofluids and (2) to prepare messenger RNA (mRNA)-enriched sequencing libraries using complementary hybridization probes. Importantly, the workflow includes 2 sets of synthetic spike-in RNA molecules as processing controls for RNA purification and sequencing library preparation and as an alternative data normalization strategy. For complete details on the use and execution of this protocol, please refer to Hulstaert et al. (2020).
Tracing genealogical data with TimeNets (2010)

We present TimeNets, a new visualization technique for genealogical data. Most genealogical diagrams prioritize the display of generational relations. To enable analysis of families over time, TimeNets prioritize temporal relationships in addition to family structure. Individuals are represented using timelines that converge and diverge to indicate marriage and divorce; directional edges connect parents and children. This representation both facilitates perception of temporal trends and provides a substrate for communicating non-hierarchical patterns such as divorce, remarriage, and plural marriage. We also apply degree-of-interest techniques to enable scalable, interactive exploration. We present our design decisions, layout algorithm, and a study finding that TimeNets accelerate analysis tasks involving temporal data.
Towards customizable, application specific mobile trusted modules (2010)

Two different security extensions of mobile platforms for hosting Mobile Trusted Module (MTM) functionality have been introduced in recent years: the ARM TrustZone processor extension and Secure Elements. Both approaches can host MTMs which are typically designed as a static and fixed set of functions. However, with the increasing number of supported functions, the complexity of these MTMs is being raised and with it the resource requirements on the hosting security extension. Disembedding MTM functionality and dynamic loading of TPM commands can be a solution to reduce these requirements. In order to address this problem, we propose and analyze two approaches for providing modular, customizable MTM functionality which are based on currently available cell phones' security extensions. We propose two architectures in order to overcome the resource limitations of existing approaches and show how secure and dynamic command loading architectures can be established with the ARM TrustZone extension and Secure Elements.
Intravenous Zoledronic Acid in Postmenopausal Women With Low Bone Mineral Density (2003)

Reid, Ian R.; Brown, Jacques P.; Burckhardt, Peter; Horowitz, Zebulun; Richardson, Peter; Trechsel, Ulrich; Widmer, Albert; Devogelaer, Jean-Pierre; Kaufman, Jean-Marc; Jaeger, Philippe; Body, Jean-Jacques; Meunier, Pierre J.
Monoclonal antibody H 9/25 reacts with functional subsets of T and B cells: killer, killer precursor and plaque‐forming cells (1980)

Monoclonal antibody (McAb) H9/25 has previously been shown to react with an alloantigen expressed on subpopulations of mouse lymphocytes. We here investigated the expression of the antigen (H9/25 Ag) on functional subsets of T and B cells. Lymphocytes were depleted of H9/25 Ag-bearing cells by complement-dependent cytolysis or by the affinity to immobilized McAb H9/25, and the residual immunological functions were tested. In these tests, killer T cells generated in mixed lymphocyte cultures and their precursors were found to express H9/25 Ag. In contrast, the activity and frequency of helper T cells specific to keyhole limpet hemocyanin carrier were not decreased by the depletion of H9/25 Ag-bearing cells. On the other hand, IgG and IgM anti-TNP plaque-forming cells were found to express H9/25 Ag, while it was not detected on unprimed B cells, as tested by using TNP-Ficoll and TNP-lipopolysaccharide. Only a small proportion of TNP memory B cells seemed to express the antigen. These results revealed significant differences between H9/25 Ag and other known alloantigens in the distribution among functional subsets of lymphocytes.
Synthesis and Biological Evaluation of Highly Functionalized Analogues of Ingenol (1998)

The synthesis and preliminary biological evaluation of the first analogues of ingenol, a potent activator of protein kinase C, containing all of the oxygen functionality and unsaturation present in the natural product, is described.
Bearing Capacity of Hydrated Geosynthetic Clay Liners (1995)

Concern has been expressed about the bearing capacity of hydrated geosynthetic clay liners (CGLs), with respect to the possibility of thevarious products decreasing in thickness and thereby sacrificing their lowas-manufactured hydraulic conductivity properties. This experimental studyshows that, with adequate cover soil placement before loads are applied, thispossibility can be avoided. Traditional design of the cover soil thicknesswith respect to anticipated loadings, followed by proper installationprocedures, should be followed when utilizing GCLs.
The CXXC Motif Is More than a Redox Rheostat (2007)

The CXXC active-site motif of thiol-disulfide oxidoreductases is thought to act as a redox rheostat, the sequence of which determines its reduction potential and functional properties. We tested this idea by selecting for mutants of the CXXC motif in a reducing oxidoreductase (thioredoxin) that complement null mutants of a very oxidizing oxidoreductase, DsbA. We found that altering the CXXC motif affected not only the reduction potential of the protein, but also its ability to function as a disulfide isomerase and also impacted its interaction with folding protein substrates and reoxidants. It is surprising that nearly all of our thioredoxin mutants had increased activity in disulfide isomerization in vitro and in vivo. Our results indicate that the CXXC motif has the remarkable ability to confer a large number of very specific properties on thioredoxin-related proteins.
An Efficient Feathering System with Collision Control (2015)

We present an efficient interactive system for dressing a naked bird with feathers. In our system, a skeleton associated with guide feathers is used to describe the distribution of the body feathers. The special skeleton can be easily built by the user, given a 3D bird model as input. To address the problem of interpenetrations among feathers, the growth priority between the feather roots is defined, with which we obtain the growth order from a greedily constructed directed acyclic graph. Each feather is then adjusted in that order by a height field based collision resolution process. The height field not only provides an efficient way to detect the collision but also enables us to finely control the degree of collision during feather adjustments. The results show that our approach is capable of resolving the collisions among thousands of feathers in a few seconds. If model animation is desired, the feathers can be adjusted on the fly at interactive framerates. Details of our implementation are provided with several examples to demonstrate the effectiveness of our system.
Plasmonic Random Laser for Artefact-free Imaging (2020)

We report the use of a plasmonic random laser as an illumination source for microscopic imaging. The high correlation coefficient (0.91) quantifies the random laser’s ability to preserve information from disruptions caused by coherent artefacts.
Design and Analysis of an Ultra-Compact and Ultra-Wideband Polarization Beam Splitter Based on Coupled Plasmonic Waveguide Arrays (2007)

We present the design of an ultra-compact polarization beam splitter where three symmetrical dielectric channel waveguides are hybrid integrated with Au plasmonic waveguide arrays. Ultra-wideband operation over 50 THz with the insertion loss less than 2 dB for both transverse electric and transverse magnetic mode are predicted. The extinction ratio is better than 15 dB for both polarizations and it is realizable on a chip size as small as 0.93times4.2 mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Rapid sampling for analysis of in vivo kinetics using the BioScope: A system for continuous‐pulse experiments (2002)

In this article we present a novel device, the BioScope, which allows elucidation of in vivo kinetics of microbial metabolism via perturbation experiments. The perturbations are carried out according to the continuous-flow method. The BioScope consists of oxygen permeable silicon tubing, connected to the fermentor, through which the broth flows at constant velocity. The tubing has a special geometry (serpentine channel) to ensure plug flow. After leaving the fermentor, the broth is mixed with a small flow of perturbing agent. This represents the start of the perturbation. The broth is sampled at different locations along the tubing, corresponding to different incubation times. The maximal incubation time is 69 s; the minimally possible time interval between the samples is 3-4 s. Compared to conventional approaches, in which the perturbation is carried out in the fermentor, the BioScope offers a number of advantages. (1) A large number of different perturbation experiments can be carried out on the same day, because the physiological state of the fermentor is not perturbed. (2) In vivo kinetics during fed-batch experiments and in large-scale reactors can be investigated. (3) All metabolites of interest can be measured using samples obtained in a single experiment, because the volume of the samples is unlimited. (4) The amount of perturbing agent spent is minimal, because only a small volume of broth is perturbed. (5) The system is completely automated. Several system properties, including plug-flow characteristics, mixing, oxygen and carbon dioxide transfer rates, the quenching time, and the reproducibility have been explored, with satisfactory results. Responses of several glycolytic intermediates in Saccharomyces cerevisiae to a glucose pulse, measured using a conventional approach are compared to results obtained with the BioScope. The agreement between the results demonstrates that the BioScope is indeed a promising device for studying in vivo kinetics.
the Intelligent STB¿Implementation of Next Generation of Residential Gateway in Digital Home (2007)

As the core of digital home, RG(residential gateway) distributes services to diverse electronic appliances through different mediums. In this paper, we propose a new solution using a more intelligent STB(set top box) to fulfill tasks of RG. On the one hand, it integrates the two equipments together to cut the costs; on the other hand, it provides much more functions with good quality. We adopt the two-CPU architecture to satisfy powerful computing demands. Upon it the middleware is indispensable due to the heterogeneity of home network. Then, abundant embedded applications at the top accomplished the ultimate tasks successfully. By the way, this intelligent STB is nominated RG-STB.
[Urinary infections with hospital germs in general surgery]. (1999)

Nosocomial urinary tract infection is the most common type of sepsis in the post-surgical patient. This paper presents our experience with 218 nosocomial urinary infections (34.93% of our postoperative infections) which complicated the postoperative course of 1002 (21.75%) urethral catheterized patients out of a total of 5950 (3.6%) operated on and under study individuals. Thus we found that urethral catheterization is the most important risk factor for post-surgery urinary infections. Moreover, in our series the postoperative urinary tract sepsis bacteriology is dominated (> 95% of cases) by aerobic gram-negative bacilli that mainly reside in the bowel and also commonly colonize the perineum. Furthermore, we demonstrated that post-surgical urinary infections did not influence directly death rate but they had a significant bearing on care costs. Finally we consider the prevention of postoperative nosocomial urinary tract sepsis as an essential principle of this condition management.
Biochemical Studies on Bakanae Fungus. Part 60–62. Synthesis of Substances related to Gibberellins (1963)

Journal Article Biochemical Studies on Bakanae Fungus. Part 60–62. Synthesis of Substances related to Gibberellins: Part V. Synthesis of C-10 Epimer of 6-Ketodehydrohomogibberic AcidPart VI. Synthesis of Hydrindonecarboxylic AcidsPart. VII. Attempted Transformation of Phyllocladene Skeleton into Gibberellin Skeleton Get access Kenji Mori, Kenji Mori Department of Agricultural Chemistry, the University of Tokyo, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Makoto Matsui, Makoto Matsui Department of Agricultural Chemistry, the University of Tokyo, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Yusuke Sumiki Yusuke Sumiki Department of Agricultural Chemistry, the University of Tokyo, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 27, Issue 1, 1 January 1963, Pages 22–34, https://doi.org/10.1080/00021369.1963.10858057 Published: 01 January 1963 Article history Received: 31 August 1962 Published: 01 January 1963
Nonlinear sliding mode control of an induction motor (2000)

This paper proposes a new non-linear sliding mode controller for induction motors. The controller assumes that only the motor speed and stator currents are measured and seeks to provide asymptotic tracking of speed and flux. The control law incorporates a sliding mode observer and uses backstepping ideas to synthesis the non-linear controller sliding surfaces. Good results have been obtained in the benchmark simulations. Copyright © 2000 John Wiley & Sons, Ltd.
Abstract #3775: Mechanistic studies of AV370, a potent FGFR3 antagonistic antibody (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

The t(4;14)(p16.3;q32) translocation found in approximately 15% of patients with multiple myeloma leads to aberrant expression of 2 putative oncogenes, MMSET (a histone methyltransferase) and FGFR3 (a receptor tyrosine kinase). Patients carrying the t(4:14) translocation have a poor prognosis. Previous studies have demonstrated the oncogenic potential of FGFR3 in t(4:14) multiple myeloma, therefore targeting this receptor tyrosine kinase represents an attractive therapeutic opportunity in this patient population. Monoclonal antibodies have been developed to specifically block FGFR3 signaling in response to ligand stimulation. However, some of the tumors that harbor the t(4;14) translocation also carry mutations in FGFR3 that render the receptor constitutively active or hypersensitive to ligand stimulation. Whether antibody treatment is effective on tumors expressing mutant FGFR3 needs to be evaluated in preclinical models. The antagonistic anti-FGFR3 antibody, AV370 potently inhibits ligand-induced proliferation of FDCP cells expressing wild type FGFR3. AV370 also binds to mutant FGFR3 receptor with high affinity and inhibits the proliferation of FDCP cells driven by some mutant variants of the receptor. When tested in xenograft models using multiple myeloma cell lines, AV370 also significantly inhibited the growth of the OPM-2 xenograft that carries the K650E mutation in FGFR3. Although K650E mutation is thought to constitutively activate the receptor, we demonstrated that the tyrosine phosphorylation of this mutant receptor can be further stimulated by its ligands and AV370 could inhibit its tyrosine phosphorylation both in vitro and in vivo. Both cell surface and total FGFR3 level in OPM-2 cells were markedly reduced upon incubation with AV370. A profound receptor dowregulation in OPM-2 xenografts was also observed within 8 hours and the receptor downregulation sustained for at least 72 hours following a single dose of AV370 treatment. Similar receptor downregulation was also observed in another multiple myeloma cell line that carries a different activating mutation. Inhibition of receptor phosphorylation and induction of receptor downregulation by AV370 could bring therapeutic benefits to multiple meyloma patients with t(4:14) translocation.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 3775.
Semiadaptive Synergic-Fill Welding Tractor for Ship Unit Erection (2003)

At most U.S. shipyards, the bottleneck for improving productivity is unit fabrication and ship erection. Fit-up during unit, super-unit, and ship erection is difficult, resulting in variable gap and mismatch, which promote defects and repair. A semiadaptive synergic-fill welding tractor was developed for improving the productivity of seam welds during erection. The tractor has many features that advanced robots have but is simple to use because it relies on operator pass planning instead of robotic path preplanning. The "synergic-fill" welding concept was developed to maximize the deployment of robust welding procedures. This was a new control process for making changes to weld bead size during fabrication using one knob. The synergic-fill welding concept was developed for flux-cored arc welding of DH36 steels for horizontal erection seams. These seams have a range of gap and require a range of weld bead sizes to uniformly fill the weld seam. Welding parameters that ensured a constant base metal dilution were optimized and programmed into the synergic control. In addition, the welding tractor was developed with a laser seam tracking vision sensor and adaptive-fill control. The new control allows the operator to intervene during welding and toggle the adaptive features on and off. A special four-axis tractor was developed to permit cross-seam and torch height control for seam tracking while oscillating the welding torch. The laser sensor was integrated with modular fixturing to permit welding with either angled or transverse oscillation. The adaptive control algorithm varied the weld size from the synergic-fill starting point that was selected by the operator. The weld bead was made proportionally larger or smaller as the joint width became larger or smaller within the process capability range. A semiadaptive control algorithm was developed for the horizontal welding application. The process was not completely automatic. The operator, who plans the position of the welding torch for each weld bead in a layer, applies the process. Further, he made weld bead size decisions based on the joint width. Once the welding system was started, it tracked the bead location as the groove width changed, controlled the torch height, and can adaptively vary bead size relative to joint width. This flexible technology will minimize the susceptibility to defects during erection welding.
Evaluation of a Double-Entry Turbine Model Coupled With a One-Dimensional Calibrated Engine Model at Engine Full Load Curves (2021)

Turbocharging is one of the foremost ways of engine downsizing and represents the leading technology for reducing the engine CO 2 emission standards in gasoline engine application. Turbocharger turbine always faces high unsteadiness of flow coming from the reciprocating internal combustion engines. Besides, increasing levels of engine downsizing include rising degrees of pulse charging. Utilization of pulse energy in the engine exhaust and reducing the interferences between the cylinders using the double-entry turbines is a vital element in solving the low-end-torque targets and improving rated power in highly boosted four-cylinder engines. The present paper describes a model of double-entry turbines. The model’ aim is to accommodate an efficient boundary condition to turbocharged engine models with zero and one-dimensional gas dynamic codes. The model is based on the simple procedure of testing and systematizing the performance maps of these turbines with different flow admission conditions. However, the described model in the present paper is capable of extrapolating operating conditions that differ from those included in the turbine maps because a turbocharger turbine with an engine usually works instantaneously and away from the narrow range of data that are measured in the gas stand. The described model has been implemented in a one-dimensional gas dynamic code and has been used to calculate unsteady operating conditions coming from the engine. The results obtained from the whole engine simulation show that the model can produce all the full load engine variables such as air mass flow and brake torque in a reasonable degree of agreement with the experimental data that are obtained from the engine test bench.
The cyclic peptide labaditin does not alter the outer membrane integrity of Salmonella enterica serovar Typhimurium (2019)

Antimicrobial peptides are a promising class of new antibiotics with the ability to kill bacteria by disrupting their cell membrane, which is especially difficult for Gram-negative bacteria whose cell wall contains an outer layer of lipopolysaccharides (LPS). Here we show that the cyclic decapeptide Labaditin (Lo), with proven activity against the Gram-positive Staphylococcus aureus and Streptococcus mutans, is not able to kill the Gram-negative Salmonella enterica serovar Typhimurium (S.e.s. Typhimurium). We found that Lo induced significant changes in the surface pressure isotherms of Langmuir monolayers representing the Salmonella enterica serovar Typhimurium inner membrane (S.e.s. Typhimurium IM), and caused leakage in large unilamellar vesicles made with this IM lipid composition. On the basis of these results one should expect bactericidal activity against S.e.s. Typhimurium. However, Lo could not interact with a monolayer of LPS, causing no significant changes in either the surface pressure isotherms or in the polarization-modulated infrared reflection absorption spectra (PM-IRRAS). Therefore, the failure of Lo to kill S.e.s. Typhimurium is associated with the lack of interaction with LPS from the outer bacteria membrane. Our approach with distinct monolayer compositions and combined techniques to investigate molecular-level interactions is useful for drug design to fight antibiotic-resistant bacteria.
Double Pseudo Affine Projection Algorithm For Speech Enhancement And Acoustic Noise Reduction (2012)

Publication in the conference proceedings of EUSIPCO, Bucharest, Romania, 2012