gebhart/patrepeval huggingface dataset:
Iterative techniques for minimum phase signal reconstruction from phase or magnitude (1981)

In this paper, we develop iterative algorithms for reconstructing a minimum phase sequence from the phase or magnitude of its Fourier transform. These iterative solutions involve repeatedly imposing a causality constraint in the time domain and incorporating the known phase or magnitude function in the frequency domain. This approach is the basis of a new means of computing the Hilbert transform of the log-magnitude or phase of the Fourier transform of a minimum phase sequence which does not require phase unwrapping. Finally, we discuss the potential use of this iterative computation in determining samples of the unwrapped phase of a mixed phase sequence.
Selective visuo-haptic rendering of heterogeneous objects in &#x201C;parallel universes&#x201D; (2014)

Haptic rendering of complex models is usually prohibitive due to its much higher update rate requirement compared to visual rendering. Previous works have tried to solve this issue by introducing local simulation or multi-rate simulation for the two pipelines. Although these works have improved the capacity of haptic rendering pipeline, they did not take into consideration the situation of heterogeneous objects in one scenario, where rigid objects and deformable objects coexist in one scenario and close to each other. In this paper, we propose a novel idea to support interactive visuo-haptic rendering of complex heterogeneous models. The idea incorporates different collision detection and response algorithms and have them seamlessly switched on and off on the fly, as the HIP travels in the scenario. The selection of rendered models is based on the hypothesis of “parallel universes”, where the transition of rendering one group of models to another is totally transparent to users. To facilitate this idea, we proposed a procedure to convert the traditional single universe scenario into a “multiverse” scenario, where the original models are grouped and split into each parallel universe, depending on the scenario rendering requirement rather than just locality. We also proposed to add simplified visual objects as background avatars in each parallel universe to visually maintain the original scenario while not overly increase the scenario complexity. We tested the proposed idea in a haptically-enabled needle thoracostomy training environment and the result demonstrates that our idea is able to substantially accelerate visuo-haptic rendering with complex heterogeneous scenario objects.
Characterization of Pre- and Post-Service Grain Boundary Phases in a Cast Austenitic Steel (2011)

Austenitic steel castings are currently being used in components for industrial gas turbine engines. Service experience has indicated a degradation of mechanical properties with extended exposures at elevated temperature. The purpose of this study was to characterize the grain boundary phases that develop during the casting processes as a likely explanation for the observed performance. In order to isolate these precipitates, a variety of electron microscopy characterization techniques were used to characterize their composition after various heat treatments and service exposure. In the baseline, as-cast and annealed condition, a discontinuous network of grain boundary metal carbides was observed. These precipitates coarsened during short-term annealing at 649°C and a denuded zone formed in the adjacent matrix. When the 38,600 h service-exposed material was analyzed, the grain boundaries were highly decorated with a more continuous film of grain boundary carbides as well as voids attributed to creep cavitation. In addition to carbides, acicular AlN precipitates were identified on the grain boundaries of the casting examined after service exposure.
Highly Active Heterogeneous Palladium Nanoparticle Catalysts for Homogeneous Electrophilic Reactions in Solution and the Utilization of a Continuous Flow Reactor (2010)

A highly active heterogeneous Pd-nanoparticle catalyst for the intramolecular addition of phenols to alkynes was developed and employed in a continuous flow reaction system. Running the reaction in flow mode revealed reaction kinetics, such as the activation energy and catalyst deactivation, and provides many potential practical advantages.
Abstract 5381: VLA-4 targeted nanoparticles deliver a cMYC-MAX prodrug antagonist extends survival a metastatic myeloma mouse model (2014)

Abstract Background: While it is well known that MYC oncoprotein drives multiple myeloma (MM) pathogenesis, the development of several small-molecule inhibitors of the c-MYC/MAX interaction has been limited by rapid systemic metabolism, poor bioavailability and the inability of the drug to reach inhibitory concentrations in the tumor. Objective: The goal of this study was to develop and deliver an effective VLA-4-targeted Sn 2 lipase-labile Myc-inhibitor nanotherapy. Experimental Methods: A novel Sn 2 phosphatidylcholine-cMyc-Max antagonist prodrug (M1-PD) was designed, synthesized, characterized and evaluated in vitro and in vivo. In vitro, titrated free M1-PD was compared to free Myc-antagonist in human MM cell lines (H929 and U266) and mouse MM (5TGM1). M1-PD was incorporated into two lipid-based nanoparticle genera (&amp;lt;20nm and ∼200nm) that were functionalized for MM targeting using a peptidomimetic VLA-4-lipid ligand. The nanoparticles were physico-chemically characterized and evaluated for their relative pharmacokinetics in vivo. Effectiveness of the two VLA-4-targeted M1-PD nanotherapies were evaluated in MM cell cultures, correlated with VLA-4 expression levels, and then studied in C57BL/KaLwRij mice with metastatic 5TGM1. Results: Bioactivity of free M1-PD was several orders magnitude more potent that the free cMyc antagonist in cell culture. Binding and efficacy of M1-PD nanoparticles correlated with integrin expression in target cells. VLA-4-M1-PD nanoparticles (&amp;lt;20nm and ∼200nm) equivalently inhibited MM cell growth in vitro compared to controls. In C57BL/KaLwRij mice with metastatic 5TGM1, VLA-4-MI1-PD 20nm micelles conferred significant survival benefit (T/D) over the 20nm targeted no drug (T/ND) or untreated controls (NT/ND) (52 days vs. 29 days, p=0.001) and versus the 200nm VLA-4-MI1-PD nanocolloid and its controls. Conclusion: These finding support the feasibility of a new VLA-4-directed nanotherapy to deliver lipase-labile cMyc prodrug to disrupt MYC-MAX dimerization and improve MM survival. Citation Format: Deepti Soodgupta, Dipanjan Pan, Grace Cui, Angana Senpan, Xiaoxia Yang, Samuel A. Wickline, Edward V. Prochownik, Katherine N. Weilbaecher, Michael H. Tomasson, Gregory M. Lanza. VLA-4 targeted nanoparticles deliver a cMYC-MAX prodrug antagonist extends survival a metastatic myeloma mouse model. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5381. doi:10.1158/1538-7445.AM2014-5381
Farm dust decreases Th2 driven allergic airway inflammation in mice: A role for airway TLR2 and TLR4? (2011)

Exposure to farm dust is known to decrease allergic inflammation in an ovalbumin mouse model for asthma. However, the underlying mechanisms of this protection are not known. With the focus on the role of epithelium in this process, we investigated whether farm dust also protects against allergic airway inflammation in a more clinically relevant house dust mite (HDM) asthma mouse model. Dust from different farms in Germany was collected and pooled. BALB/c mice were exposed intranasally 4 times/week for 5 weeks to PBS or farm dust (1 mg/ml, 50 μl/day), followed by PBS or HDM (2.5 mg/ml, 10 μl/day). IgE levels, inflammatory cells, cytokines (CC chemokine ligand (CCL)20, thymic stromal lymphopoietin (TSLP) and Th2) and Toll-like receptor (TLR)2 and TLR4 expression on epithelial cells were assessed. Farm dust+HDM exposed mice had lower levels of HDM-specific IgE in serum, eosinophilic inflammation, and Th2 cytokines in lungs than HDM exposed mice. Expression of TLR2 and 4 in epithelium, and CCL20 and TSLP levels in lung tissue were lower in farm dust exposed than HDM exposed mice. Additionally, we observed less spindle shaped CD68+ cells beneath the epithelial basement membrane in farm dust exposed mice. Lower expression of TLR2 and 4 in epithelium after farm dust exposure may explain the lower levels epithelial cell-derived cytokines CCL20 and TSLP. These lower CCL20 and TSLP levels could have prevented the recruitment of antigen presenting cells as evidenced by the spindle shaped CD68+ cells, as well as the skewing towards a Th2 response. Hence, lower expression of TLR2 and 4 may contribute to the observed protection against HDM-induced allergic inflammation in farm dust-exposed mice.
A Survey of Multi-Way Channels in Information Theory: (1977)

The advances in the area of multi-way channels during the period 1961-1976 are described. Shannon's two-way channel, the multiple-access channel, the interference channel, the broad- cast channel, and the relay channel are treated successively. Only channel coding aspects are discussed. Thirty-nine open problems are mentioned.
Analyzing epigenetic control of galectin expression indicates silencing of galectin‐12 by promoter methylation in colorectal cancer (2017)

Galectins, a class of lectins with specificity for ß-galactoside containing glycoconjugates, modulate several cellular processes that are involved in the control of normal cell growth, differentiation, cell-cell, and cell matrix interactions. Pathological alterations of the galectin expression pattern have been implicated in the development and progression of cancer. We therefore analyzed epigenetic mechanisms for control of galectin expression in 9 colorectal cancer (CRC) cell lines. Our data demonstrate that expression of galectins-1, -2, -7, -8, and -9 can be regulated by histone acetylation in CRC cell lines. In addition, the same set of galectins was also found to be modulated by DNA methylation. Of particular note, galectin-12 is silenced in all tested CRC cell lines but known to be re-expressed upon butyrate-induced differentiation and present in normal colonic mucosa. Loss of galectin-12 expression in undifferentiated CRC cells is associated with promoter hypermethylation and for the first time we provide detailed methylation analysis of the promoter region. In CRC tumor tissue, galectin-12 expression was downregulated in 66% of CRC tissue specimens as compared to adjacent normal tissue hinting to a possible tumor-suppressing function in CRC. © 2017 IUBMB Life, 69(12):962-970, 2017.
Essential Thrombocythemia (2019)

Essential thrombocythemia is associated with increased risks of bleeding and thrombosis. Estimation of the risk of thrombosis is based on history of thrombosis, presence of the JAK2 V617F mutation, age, and cardiovascular risk. Treatment commonly involves low-dose aspirin; therapy is used in patients with high thrombotic risk.
Supplementary Figure 5 from Hypoxia-Regulated Overexpression of Soluble VEGFR2 Controls Angiogenesis and Inhibits Tumor Growth (2023)

&lt;p&gt;PDF - 3176KB, Characterization of B16F10 wt and msVEGFR2 expressing clones 13.3 and 16.4 tumors in vivo.&lt;/p&gt;
Improved 3-D Particle Tracking Velocimetry with Colored Particles (2011)

The present work introduces an extension to three-dimensional Particle Tracking Velocimetry (3-D PTV) in order to investigate small-scale flow patterns. Instead of using monochrome particles the novelty over the prior state of the art is the use of differently dyed tracer particles and the identification of particle color classes directly on Bayer raw images. Especially in the case of a three camera setup it will be shown that the number of ambiguities is dramatically decreased when searching for homologous points in different images. This refers particularly to the determination of spatial parti- cle positions and possibly to the linking of positions into trajectories. The approach allows the handling of tracer parti- cles in high numbers and is therefore perfectly suited for gas flow investigations. Although the idea is simple, difficult- ties may arise particularly in determining the color class of individual particle when its projection on a Bayer sensor is too small. Hence, it is not recommended to extract features from RGB images for color class recognition due to infor- mation loss during the Bayer demosaicing process. This article demonstrates how to classify the color of small sized tracers directly on Bayer raw images.
Detailed Measurement of Oxidizer-Rich Staged Combustion Injector Dynamics in Model Rocket Combustors (2021)

This paper presents experimental results from a model rocket combustor that uses a gas-centered swirl-coaxial injector element injecting warm oxygen and ambient temperature RP-2 fuel with 900 psia chamber pressure, representative of an oxidizer-rich staged combustion cycle. Results from the two injector geometries are analyzed and compared. One was a flat-faced injector with the element ending at a sudden expansion into the chamber. The other used a truncated cone at the injector exit: a design feature of specific interest that appears in drawings for the RD-170 main-chamber injector. To improve spatial resolution of high-frequency pressure measurements, the model injector was scaled up from RD-170 dimensions to facilitate measurements in the injector and head end of the combustor. Measured pressure spectra of the flat-face combustor showed a well-organized first axial mode and harmonics. The truncated-cone geometry showed a more diffuse spectra with higher-frequency modes, with a reduction in amplitude further upstream in the cone. Intermittency in measured dynamics is characterized via multiscale analysis. Adopting concepts from fractal theory, the stability margin of the injector configurations was quantified using the Hurst exponent of pressure oscillations. Comparatively, a larger range of fractal dimensions with smaller fluctuations in the initial reacting zone were observed for the flat-face injector.
BRAVISSIMO study: 12-month results from the TASC A/B subgroup. (2012)

Endoleaks are one of the most common reasons for reinterventions and failure after endovascular aneurysm repair (EVAR). Current classifications divide endoleaks into type I-V but a more pragmatic definition is of direct and indirect endoleaks. Direct endoleaks (type I and III) transmit direct systemic pressure to the aneurysm sac and carry a high risk of aneurysm growth and rupture if left untreated. Immediate intervention is generally warranted. Indirect endoleaks (type II, IV, V) may have a more benign course and should be treated only under the presence of aneurysm growth. Appropriate procedural planning and device selection is critical to avoid endoleaks and most direct endoleaks can be identified and treated periprocedurally by use of high quality intraoperative imaging techniques. Late endoleaks can be treated predominately by endovascular means and the need for conversion to open surgery is rare.
Fowl typhoid and pullorum disease (2000)

Fowl typhoid (FT) and pullorum disease (PD) are septicaemic diseases, primarily of chickens and turkeys, caused by Gram negative bacteria, Salmonella Gallinarum and S. Pullorum, respectively. Clinical signs in chicks and poults include anorexia, diarrhoea, dehydration, weakness and high mortality. In mature fowl, FT and PD are manifested by decreased egg production, fertility, hatchability and anorexia, and increased mortality. Gross and microscopic lesions due to FT and PD in chicks and poults include hepatitis, splenitis, typhlitis, omphalitis, myocarditis, ventriculitis, pneumonia, synovitis, peritonitis and ophthalmitis. In mature fowl, lesions include oophoritis, salpingitis, orchitis, peritonitis and perihepatitis. Transovarian infection resulting in infection of the egg and subsequently the chick or poult is one of the most important modes of transmission of these two diseases. Salmonella Gallinarum and S. Pullorum can be isolated by use of selective and non-selective media. Salmonella Pullorum produces rapid decarboxylation of ornithine whereas S. Gallinarum does not, an important biochemical difference between the two bacteria. Both FT and PD can be detected serologically by use of a macroscopic tube agglutination test, rapid serum test, stained antigen whole blood test or microagglutination test. Both diseases can be controlled and eradicated by use of serological testing and elimination of positive birds. Vaccines may be used to control the disease and antibiotics for the treatment of FT and PD. Although FT and PD are widely distributed throughout the world, the diseases have been eradicated from commercial poultry in developed countries such as the United States of America, Canada and most countries of Western Europe. Both S. Gallinarum and S. Pullorum are highly adapted to the host species, and therefore are of little public health significance.
Carrier concentration and temperature dependence of the electronic transport properties of epitaxial PbTe and PbTe/PbSe nanodot superlattices (2008)

The electrical conductivity, Seebeck coefficient, and power factor of $n$- and $p$-type PbTe were calculated over the temperature range of 300--700 K and carrier concentration range of $1\ifmmode\times\else\texttimes\fi{}{10}^{17}\ensuremath{-}4\ifmmode\times\else\texttimes\fi{}{10}^{19}\text{ }{\text{cm}}^{\ensuremath{-}3}$ by using the Boltzmann transport equation and relaxation time approximation and were compared to measurement results. A three-band model for PbTe was used and included scattering from screened polar optical phonons as well as the deformation potential of acoustic and optical phonons. Nonparabolicity and anisotropy of the principal conduction and valence bands at the $L$ point in the Brillouin zone were taken into account, and the calculated transport properties were in excellent agreement with measurement results over the full range of carrier concentrations and temperatures. The Lorenz number was also calculated and seen to vary from 0.54 to 0.89 of ${L}_{0}$ $(2.44\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}8}\text{ }\text{W}\text{ }\ensuremath{\Omega}\text{ }{\text{K}}^{\ensuremath{-}2})$ depending on the carrier concentration and temperature. The measured in-plane transport properties of epitaxially grown $n$- and $p$-type PbTe/PbSe nanodot superlattice (NDSL) samples with $\ensuremath{\sim}13%$ PbSe by volume fraction are also presented and discussed in comparison to the baseline homogeneous PbTe. The presence of the PbSe nanodots in a PbTe matrix was observed to reduce the carrier mobility by $\ensuremath{\sim}25%--35%$ while having no effect on the Seebeck coefficient, thus resulting in a reduced power factor for PbTe/PbSe NDSLs compared to PbTe. The properties of the NDSL samples were also observed to have the same temperature dependence as PbTe.
Enhanced skin regeneration by nanoegg formulation of all-trans retinoic acid. (2006)

All-trans retinoic acid (atRA) which could smooth wrinkles and produce less pigmented skin after a few months of treatment has been studied in research into topical treatments for a potent inhibitor of new melanin production. However, the clinical responses of commercial atRA cream predominantly comprise severe inflammation. We report a novel nanotechnology "nanoegg" system giving improved effects of atRA self-assembly which were coated by CaCO3. Dorsal areas of hairless mouse and porcine skin were employed for administration of nanoegg ointment and commercial products. The mRNA for heparin-binding epidermal growth factor-like growth factor (HB-EGF) from tissues was measured by a real-time PCR method. All tissues were stained for detection of hyaluronate and the thickness of the epidermis. A clinical trial in humans was carried out at St. Marianna University in Japan. As a result, the irritation and inflammation associated with atRA molecules were substantially reduced. The physicochemical instability of atRA was also dramatically improved. Furthermore, nanoegg enhanced marked expression of mRNA for HB-EGF from keratinocytes, which is known as one of the markers of keratinocyte turnover. Also, production of hyaluronate was surprisingly in the intercellular spaces of the basal and spinous cell layers 2 days after treatment. Even at the low concentration of atRA in the nanoegg system, the proliferation and differentiation of keratinocyte was somewhat enhanced. A nanoegg may thus not only prevent adverse effects, but also markedly enhance the main effect.
Biochemical and Immunologic Effects of Rituximab in Patients With Primary Biliary Cirrhosis and an Incomplete Response to Ursodeoxycholic Acid (2011)

These data suggest that depletion of B cells influences the induction, maintenance, and activation of both B and T cells and provides a potential mechanism for treatment of patients with PBC with an incomplete response to UDCA.
Analysis of high frequency vibrations and heat impact on human hands (2017)

This article describes combined impact of ultrasound and heat therapies on patients with rheumatoid arthritis, systemic scleroderma and Raynaud’s syndrome. Theoretical background of ultrasound and thermal effect was analyzed and described. Flexibility, strength and temperature of subjects’ wrists and hands were investigated using thermographic camera, dynamometer, and physiological indicators. Investigation results were analyzed and demonstrated in graphs.
Supplementary Figure 3 from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia (2023)

&lt;p&gt;Suppl. figure 3: Dexamethasone and dexamethasone+KPT-8602 treatment induce NR3C1 binding and leads to differential gene expression of the bound genes in the SUP-T1 cell line&lt;/p&gt;
An Arabic Speech-Act and Sentiment Corpus of Tweets (2018)

Speech acts are the type of communicative acts within a conversation. Speech act recognition (aka classification) has been an active research in recent years. However, much less attention was directed towards this task in Arabic due to the lack of resources for training an Arabic speech-act classifier. In this paper we present ArSAS , an Arabic corpus of tweets annotated for the tasks of speech-act recognition and sentiment analysis. A large set of 21k Arabic tweets covering multiple topics were collected, prepared and annotated for six different classes of speech-act labels, such as expression, assertion, and question. In addition, the same set of tweets were also annotated with four classes of sentiment. We aim to have this corpus promoting the research in both speech-act recognition and sentiment analysis tasks for Arabic language.
The GlucoWatch®biographer: a frequent, automatic and noninvasive glucose monitor (2000)

The GlucoWatch (Cygnus, Inc, Redwood City, CA, USA) biographer provides automatic, frequent and noninvasive blood glucose measurements for up to 12 h. The device extracts glucose through intact skin where it is measured by an amperometric biosensor. Clinical trials in a variety of environments have shown that the biographer provides accurate and precise glucose measurements when compared with serial fingerstick blood glucose measurements. Mean difference between these measurements was 0.26 mmol/L in the home environment (r = 0.80). Over 94% of biographer readings were in the clinically acceptable A+B region of the Clarke Error Grid. A slight positive bias is observed for the biographer readings at low glucose levels. Biographer precision, as measured by coefficient of variation (CV)%, is approximately 10%. The low glucose alert function of the biographer was able to detect up to 75% of hypoglycaemic episodes with a low false alert level. Skin irritation, characterized by erythema and oedema was either nonexistent or mild in over 87% of subjects and resolved in virtually all subjects without treatment in several days. The GlucoWatch biographer has been shown to be a safe and effective method to track glucose level trends and patterns, which should enable improved glycaemic control for many patients.