gebhart/patrepeval huggingface dataset:
Silencing of Phosphoethanolamine N-Methyltransferase Results in Temperature-Sensitive Male Sterility and Salt Hypersensitivity in Arabidopsis (2002)

S-Adenosyl-L-methionine:phosphoethanolamine N-methyltransferase (PEAMT; EC 2.1.1.103) catalyzes the key step in choline (Cho) biosynthesis, the N-methylation of phosphoethanolamine. Cho is a vital precursor of the membrane phospholipid phosphatidylcholine, which accounts for 40 to 60% of lipids in nonplastid plant membranes. Certain plants use Cho to produce the osmoprotectant glycine betaine, which confers resistance to salinity, drought, and other stresses. An Arabidopsis mutant, t365, in which the PEAMT gene is silenced, was identified using a new sense/antisense RNA expression system. t365 mutant plants displayed multiple morphological phenotypes, including pale-green leaves, early senescence, and temperature-sensitive male sterility. Moreover, t365 mutant plants produced much less Cho and were hypersensitive to salinity. These results demonstrate that Cho biosynthesis not only plays an important role in plant growth and development but also contributes to tolerance to environmental stresses. The temperature-sensitive male sterility caused by PEAMT silencing may have a potential application in agriculture for engineering temperature-sensitive male sterility in important crop plants.
BGEM: An In Situ Hybridization Database of Gene Expression in the Embryonic and Adult Mouse Nervous System (2006)

This article describes an open-access gene expression database analyzed for more than 2,000 genes on mouse nervous system tissue in the coronal, sagittal, and transverse orientation representing multiple developmental ages.
ChemInform Abstract: A New Efficient Synthesis of Efaroxan. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
New Polymorphs of Fluconazole: Results from Cocrystallization Experiments (2011)

Fluconazole is known as an antifungal drug since 1983. Its propensity for the formation of new polymorphs and salts has been reported in the literature, mostly by powder X-ray diffraction and solid state Raman spectroscopy. In the present study, we are elucidating the structures of four polymorphs of fluconazole using single crystal X-ray diffraction. Raman spectra of the single crystals of these polymorphs also support our study. These polymorphs were grown in the presence of the cocrystal formers. This indicates that fluconazole interacts with the cocrystal former in the solution, and possibly these interactions result into the generation of new polymorphs of it. These polymorphs of fluconazole exhibit the conformational flexibility of the molecule, and hence we observed seven different conformers of the molecule in the reported polymorphs. Although these forms have strong O–H···N hydrogen bonds, the nature of the packing of the molecules is a cumulative effect of a number of weaker intermolecular forces such as C–H···O, C–H···N, and C–H···F and the strong hydrogen bond.
Cell migration during heart regeneration in zebrafish (2016)

Zebrafish possess the remarkable ability to regenerate injured hearts as adults, which contrasts the very limited ability in mammals. Although very limited, mammalian hearts do in fact have measurable levels of cardiomyocyte regeneration. Therefore, elucidating mechanisms of zebrafish heart regeneration would provide information of naturally occurring regeneration to potentially apply to mammalian studies, in addition to addressing this biologically interesting phenomenon in itself. Studies over the past 13 years have identified processes and mechanisms of heart regeneration in zebrafish. After heart injury, pre-existing cardiomyocytes dedifferentiate, enter the cell cycle, and repair the injured myocardium. This process requires interaction with epicardial cells, endocardial cells, and vascular endothelial cells. Epicardial cells envelope the heart, while endocardial cells make up the inner lining of the heart. They provide paracrine signals to cardiomyocytes to regenerate the injured myocardium, which is vascularized during heart regeneration. In addition, accumulating results suggest that local migration of these major cardiac cell types have roles in heart regeneration. In this review, we summarize the characteristics of various heart injury methods used in the research community and regeneration of the major cardiac cell types. Then, we discuss local migration of these cardiac cell types and immune cells during heart regeneration. Developmental Dynamics 245:774-787, 2016. © 2016 Wiley Periodicals, Inc.
Mechanical design of a superconducting demonstrator for magnetic density separation (2021)

The focus of this paper is on the mechanical design of a NbTi-based demonstrator magnet for magnetic density separation (MDS) that is being constructed at the University of Twente. MDS is a new recycling technology that allows the separation of non-magnetic particles based on their mass density, using a vertical magnetic field gradient and a ferrofluid. The unique mechanical design challenge for this type of magnet is the desired minimization of the distance between a ~1 m 2 planar array of cryogenic racetrack coils and the ambient-temperature ferrofluid bath. The optimization of the magnet geometry results in a distance between the coils and ferrofluid of 50 mm. This is made possible by opting for conduction-cooling, for the inclusion of room-temperature rods that pass through the cold mass to support the cryostat, and for the geometry of the cassette that reacts to the Lorentz force.
C455Rnotch3mutation in a Colombian CADASIL kindred with early onset of stroke (2002)

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations in the notch3 epidermal growth factor-like repeats. A Colombian kindred carries a novel C455R mutation located in the predicted ligand-binding domain. Stroke occurred in the patients at an unusually early age (median age: 31 years) in comparison to the more frequent onset in the fourth decade of life in other CADASIL populations, including a second Colombian kindred with an R1031C mutation.
Lawrence Livermore National Laboratory FY2014 Laboratory Directed Research and Development Annual Report (2015)

A broad description of the LDRD Program, highlights of accomplishments and awards for the year, program statistics, and the LDRD portfolio-management process.
4. Inquiry, Critique, and Dissemination of Knowledge: Graduate Students Contributing to Wikipedia (2013)

Graduate students use existing knowledge and are ultimately expected to add to that knowledge. Students in a Masters of Education entry course were asked to find a Wikipedia page related to the course topics, critique it, and make improvements to it to begin to develop these skills. In this paper, I examine ways in which their perspectives were transformed (Mezirow, 1991) regarding their roles in knowledge use and construction and how they grew as a result.
Device Localization Using mmWave Ranging with Sub-6-Assisted Angle of Arrival Estimation (2018)

Millimeter wave (mmWave) communication is a promising solution for achieving high data rates and low latency in future wireless networks. 5G systems are expected to fulfill these strict requirements using, among others, mm Waves. The nature of the communication in these bands considering human mobility make the challenges even complex for reasons like high beam training overhead. Features like ranging and localization are becoming key to overcome these limitations. In this paper, we address the problem of device localization in the mm Wave band. We propose a solution that leverages the co-existence of Sub-6 GHz and mmWave connectivity at access and mobile nodes. Our solution relies on Angle of Arrival estimation using Sub-6 signal at the access node. This information is provided to the mmWave part for subsequent beam training phase and high- resolution ranging. To validate the proposed solution, a number of measurements are performed showing its feasibility.
Using clustering-based bagging ensemble for credit scoring (2011)

Credit scoring has gained increasing attentions from banks, which can benefit from reducing possible risks of default. Many modeling techniques have been developed to improve the accuracy of credit scoring model. Based on the analysis of relationship between the performance of ensemble model and that of base classifiers, this paper presents a clustering-based ensemble model for credit scoring. The model uses clustering algorithm to enhance the diversity between the base classifiers, then choose base classifiers that meet the accuracy requirement to vote for the final decision. A real world credit dataset from UCI database is selected as the experimental data to demonstrate the accuracy of the model. The results show that clustering-based bagging ensemble model can significantly improved the efficiency in selection of base classifiers and generalization ability and thereby show enough attractive features for credit risk management system.
Determination of glycyrrhetic acid in human plasma by HPLC-MS method and investigation of its pharmacokinetics (2008)

The assay was sensitive, accurate and convenient, and can be used for the determination of GA in human plasma. Comparison of the bioavailability and pharmacokinetic profile of GA indicated that the test and reference capsules were bioequivalent.
Multifunctional Composites with Integrated Optical Busses for Data and Sensing Applications (2006)

Embedded communication busses are being widely investigated for complex composite structures such as military vehicles and advanced civil structures. The major difficulty with such busses is coupling external devices to embedded optical and electrical cables at ingress/egress points because physical connectors are awkward and prone to mechanical failure. In this work we present several techniques for normal incidence free-space optical data porting. These techniques are used to develop and demonstrate an integrated structural optical communication bus.
The Water‐Exchange Mechanism of the [UO2(OH2)5]2+ Ion Revisited: The Importance of a Proper Treatment of Electron Correlation (2006)

The water-exchange mechanism of [UO(2)(OH(2))(5)](2+) has been reinvestigated by using ab initio molecular orbital (MO) methods. The geometries and the vibrational frequencies were computed with CAS-SCF(12/11)-SCRF and CAS-SCF(12/11)-PCM methods, which take into account static electron correlation (using the complete active space self-consistent field (CAS-SCF) technique, based on an active space of 12 electrons in 11 orbitals) and hydration (using the self-consistent reaction field (SCRF) and polarizable continuum model (PCM) techniques). The total energies were computed with multiconfiguration quasi-degenerate second-order perturbation theory, the MCQDPT2(12/11)-PCM method, which treats static and dynamic electron correlation as well as hydration. The adequacies of other currently used quantum chemical methods, MP2, CCSD(T), B3 LYP, and BLYP, are discussed. For the associative and dissociative pathways, thermodynamic activation parameters (DeltaH( not equal), DeltaS( not equal), and DeltaG( not equal)) were computed. For the associative mechanism, the calculated DeltaH( not equal) and DeltaG( not equal) values agree with experiment, whereas for the dissociative mechanism, they are higher by approximately 20 kJ mol(-1). The dissociative mechanism is preferred for substitution reactions of uranyl(VI) complexes with ligands that are stronger electron donors than water. The question of whether a concerted (I(a) or I(d)) or a stepwise (A or D) mechanism operates is discussed on the basis of the computed lifetime of the respective intermediate, and the duration of the vibration with which the intermediate is transformed into the product.
An adaptive multicarrier wireless access system (2002)

Broadband wireless technology appears to be one of the competitive solutions for the last mile problem. Wireless access systems enable one to incrementally roll out infrastructure and rapidly turn up new services such as high-speed Internet access and video distribution. In this paper, implementation challenges toward an adaptive orthogonal frequency division multiplexing (OFDM) point-to-multipoint outdoor broadband wireless access system are examined. The frequency band tackled is located at 10.5 GHz but the results can be applied to other areas of the spectrum as well. The targeted bit rates go up to 34 Mbps, for varying channel conditions. Dynamic time division multiple access/time division duplex (DTDMA/TDD) is selected for the medium access scheme, since TDD requires only a single unpaired frequency band (thus reducing the cost for purchasing licensed spectrum), while TDMA distributes the number of slots per uplink or downlink direction according to the traffic that each direction has to transmit. In addition, OFDM techniques provide a robust behavior in the presence of multipath fading. This paper focuses on the wireless data link control (W-DLC) layer, addressing the system protocol stack and all W-DLC sublayers, entities and functions, and providing a framework that will be beneficial for a licensed outdoor wireless system.
Tauberian Theory for Multivariate Regularly Varying Distributions with\n Application to Preferential Attachment Networks (2014)

Abel-Tauberian theorems relate power law behavior of distributions and their\ntransforms. We formulate and prove a multivariate version for non-standard\nregularly varying measures on $\\mathbb{R}_+^p$ and then apply it to prove that\nthe joint distribution of in- and out-degree in a directed edge preferential\nattachement model has jointly regularly varying tails.\n
ChemInform Abstract: Enantioselective Synthesis of α‐Hydroxyphosphinic Acid Derivatives Through Hydrophosphinylation of Aldehydes Catalyzed by Al‐Li‐BINOL Complex. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Menopausal Transition—Endocrinology (2008)

An extensive database on the endocrinology of the menopause transition, including both cross-sectional and longitudinal information, has been obtained.
Vessel Boundary Delineation on Fundus Images Using Graph-Based Approach (2011)

This paper proposes an algorithm to measure the width of retinal vessels in fundus photographs using graph-based algorithm to segment both vessel edges simultaneously. First, the simultaneous two-boundary segmentation problem is modeled as a two-slice, 3-D surface segmentation problem, which is further converted into the problem of computing a minimum closed set in a node-weighted graph. An initial segmentation is generated from a vessel probability image. We use the REVIEW database to evaluate diameter measurement performance. The algorithm is robust and estimates the vessel width with subpixel accuracy. The method is used to explore the relationship between the average vessel width and the distance from the optic disc in 600 subjects.
Quality of Life Following Primary Therapy for Prostate Cancer (2008)

Patients with good-risk prostate cancers (Gleason grade 6 or 7, prostate-specific antigen [PSA] level <10, stage T1/T2) have excellent long-term
Development of a Team-Based On-Farm Learning Program While Challenging Soybean Growers to Increase Yield (2012)

Illinois soybean growers have not been satisfied with recent lagging yield trends. A yield "challenge" was created to blend the motivation and creativity of a yield contest with the learning power of teamwork and on-farm demonstration. In the initial year (2010), 123 on-farm side-by-side demonstration plots were located throughout the state; 81% of those locations showed increased soybean yields through additional management, and 55% of the experimental challenge plots were profitable. Participant surveys indicated that 92% learned a new production practice and that 69% would adopt experimental practices on more production acres the following year.
Synthesis of 2-Aryl Acetophenones via Hydrobromination and Oxy-isomerization of (o-Arylethynyl)benzyl Alcohols (2021)

Hydrobromination and oxy-isomerization of (<i>o</i>-arylethynyl)benzyl alcohols to yield brominated aryl ketones were achieved with bromotrimethylsilane. The substrate scope suggested that vinyl carbocations, stabilized by the conjugated aryl groups, are the reaction intermediates. 1<i>H</i>-Isochromene was also detected by <sup>1</sup>H NMR, and an isolated 1<i>H</i>-isochromene was converted to the product when retreated with TMSBr. The formation of 1<i>H</i>-isochromene is equivalent to a 6-<i>endo-dig</i> cyclization and contrasts with the corresponding reactions under basic conditions, in which the 5-<i>exo-dig</i> process dominated.
Neuroblastoma cell detection by reverse transcriptase‐polymerase chain reaction (RT‐PCR) for tyrosine hydroxylase mRNA (1994)

The presence of tumour cells in peripheral blood of neuroblastoma patients is of considerable clinical importance. Nucleic acid amplification offers an opportunity to detect very small numbers of such cells, but in neuroblastoma a frequent specific abnormality in the tumour DNA suitable for this purpose has yet to be identified. To facilitate the detection of such cells we have developed RT-PCR using tyrosine hydroxylase (TH) as a tissue-specific target gene. TH mRNA was detected in 3 neuroblastoma cell lines and in all neuroblastoma tumours examined, but was undetectable in peripheral blood from children without neuroblastoma. The method was highly sensitive, detecting 1-10 neuroblastoma cells per 10(7) blood cells. Thirty blood samples from 24 patients were analysed and results were compared with known disease status. At diagnosis 4/7 patient blood specimens were positive; the four positive samples were from stage-4 patients. In blood samples from these patients 6-8 weeks after the initiation of treatment, TH mRNA was undetectable. Of 7 samples taken at the time of clinical relapse, 5 were positive; 4 of these were from patients with evidence of disseminating disease. Of 16 blood samples from disease-free patients, 14 were negative and 2 were positive. One positive patient in this group subsequently had a clinical relapse. These results show that this technique is of value for detecting neuroblastoma cells in peripheral blood. The significance of these cells at diagnosis, during treatment or on follow-up requires further evaluation.
Drive-Current-Free Switch With Internal Transduction in a Magneto Piezo-Electronic Transistor (2019)

In response to the challenges of clock speed promotion and power consumption in digital switches, a concept of internal transduction, wherein voltage is transduced to a state internal to the device, which is gated and then transduced back to voltage, was once proposed and highlighted. So far, no embodiments have been demonstrated to perform at a level that would make it competitive with the conventional field-effect transistors moving forward. Here, this natural next step is pursued, and a new method is utilized to transduce an acoustic pulse back to the voltage by magneto piezo-electronic transistors (PETs). These devices provide electric-field control of magnetization in order to change the resistance of the anisotropic magnetic films. Over the course of theoretical and experimental study, the film properties, electric-field manipulation performances, and parameter optimizations are explored and analyzed. The fabricated devices stably achieve a nanosecond switch in a 10-kV/cm electric field with free drive current. In addition, the linear response region is potentially working as a sensor or an actuator. On the basis of this paper, a miniaturized magneto PET is designed and fabricated, in the expectation of speeding up the development of free-current-driven transistors with fast response and low power while scaling down.
Lesson 4: The Mold (2001)

No AccessTraining in Injection MoldingJul 2001Lesson 4: The MoldWalter Michaeli, Helmut Greif, Gernot Kretzschmar, Frank EhrigWalter Michaeli, Helmut Greif, Gernot Kretzschmar, Frank Ehrighttps://doi.org/10.3139/9783446401822.004SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2001Pages: 41-54Print ISBN: 978-3-446-21418-7eISBN: 978-3-446-40182-2 Copyright & Permissions© 2001 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Treatment Response and GWAS Risk Allele rs2514218 (C) of the Dopamine D2 Receptor Gene in Inpatients with Schizophrenia (2021)

Our findings suggest that the risk variant at the DRD2 locus can be used as an indicator for patients' responses to antipsychotics without direct DRD2-blocking, thereby shortening the time needed for drug selection.
Complete mitochondrial genome sequence of neotropical fish Astyanax giton Eigenmann 1908 (Ostariophysi; Characidae) (2017)

Here we report, for the first time, the complete mitochondrial genome of <i>Astyanax giton</i> which, together with other species, are popularly known as tetras. The mitogenome's length is 16,643 bp, containing 13 protein-encoding genes (CDS), two ribosomal RNAs (rRNA), 22 RNA transfer (tRNA) and one control region (D-loop). As for other vertebrates, all genes are encoded on the heavy strand except for <i>ND6</i> and eight <i>tRNA</i> genes. In the phylogenetic analyses, this species and other <i>Astyanax</i> were paraphyletic.
Patterns of Guillain-Barre syndrome in children (2007)

This study confirms that acute motor axonal neuropathy is an important Guillain-Barré syndrome subtype in Mexican children, is associated with diarrhea, and occurs seasonally.
Structural investigation of nanoporous alumina film with grazing incidence small angle X-ray scattering (2013)

Nanoporous alumina films (NPAF) have been elaborated by anodization of an aluminum film on silicon wafer. Ex situ structural characterization of the films has been achieved with grazing incidence small angle X-ray scattering under ultra high vacuum atmosphere and using a synchrotron source. The comparison of the experimental patterns with suitable modeling confirms the cylindrical geometry of the pores well as the good local hexagonal order.