gebhart/patrepeval huggingface dataset:
A server selection strategy about cloud workflow based on QoS constraint (2017)

Cloud computing is an emerging business computing model whose basic idea is to transmit all kinds of resources through the Internet such as storage resources, computing resources, bandwidth and so forth. So users do not need to purchase a large of computing systems to manage their business, on the contrary they only need to purchase the resources according to their needs in order to reduce the cost greatly. Due to the flexibility, convenience and low maintenance cost of cloud computing, more and more service providers choose to deploy their services to the cloud. However, under the influence of uncertain factors such as manufacturing technology, the price and delivery time of virtual machine also been changed. Because of these variations, it is difficult for users to select the appropriate cloud servers at a minimum cost, which will lead to a decline in user experience. To solve the problems above, this paper analyzes the performance of different Ali Cloud servers and proposes a server selection strategy according to the size of the whole instance and the required time of completing the workflow, so as to make the whole workflow instances execution costs as little as possible in the regulations. We also provide experimental results to demonstrate the effectiveness of our selection strategies.
Bortezomib and vorinostat as antitumor therapy for epithelial ovarian cancer. (2011)

e15542 Background: Treatment of women with advanced-stage epithelial ovarian cancer (EOC) has limited efficacy. Aberrant expression of ubiquitin-mediated protein degradation pathways occurs in ovarian cancer, thus we sought of determining the potential therapeutic efficacy of proteasome and HDACs inhibitors (Bortezomib and Vorinostat) as combinatorial approach for ovarian cancer treatment. Methods: The synergistic effect of bortezomib and vorinostat was evaluated by XTT assay and expressed as combination index (CI). Primary ovarian cancer cells were obtained by mechanically dissociating solid ovarian cancer specimens into single-cell suspensions and the epithelial nature of the derived cell population was confirmed with Ber-EP4 and MOC-31 markers. Activation of caspase-3 was determined by measuring the levels of PARP cleavage. Results: Isobologram analysis of EOC cell lines and primary EOC cells exposed to combinatorial treatment with bortezomib and Vorinostat revealed a strong synergistic effect with CI as low as 0.43 and no reduction in cell viability in immortalized ovarian surface cells or in normal surface epithelium. Reduction in the cell viability observed in cancer cells following exposure to bortezomib and vorinostat was consistent with onset of apoptosis as determined by morphological analysis and measurements of PARP cleavage levels. Importantly, primary EOC cells derived from borderline and recurrent ovarian carcinoma revealed highly sensitivity to bortezomib and vorinostat combination suggesting that this approach could be a new alternative treatment for recurrent EOC and borderline EOC with advance stage or invasive feature. Conclusions: This study provides the foundation for clinical testing of bortezomib and vorinostat combination as a therapy for ovarian cancer and may lead to an alternative therapeutic approach for patients affected by type of ovarian cancer that typically do not respond to conventional chemotherapy approach or who develop resistant tumor and relapse. Importantly, this combinatorial approach has potential to achieve significant anti-cancer activity using lower doses of the individual compounds, thus reducing “off-target” toxicity.
Treatment of chronic congenital lactic acidosis by oral administration of dichloroacetate (1985)

Sodium dichloroacetate (DCA) was administered orally at a dose of 50 mg per kg body weight twice or three times per day to a newborn infant with lactic acidosis of unknown cause (patient 1) and to a 15-year-old boy with mitochondrial encephalomyopathy associated with lactic acidosis (patient 2). In patient 1, during treatment with DCA, DCA accumulated in the blood judging from the findings that the urinary excretion of DCA increased cumulatively and the blood lactate level rapidly decreased to the normal range. In patient 2, the blood DCA level gradually increased during treatment to a concentration of 250 micrograms ml-1 and the blood lactate level decreased and was maintained within the normal range. DCA was detected in the brain (25 micrograms g tissue-1) and the liver, kidney and muscle (33.8, 33.8 and 26.3 micrograms g tissue-1, respectively) obtained at autopsy of patient 1, and in the cerebrospinal fluid of patient 2 at a concentration of 125 micrograms ml-1 when the blood concentration was 250 micrograms ml-1. The lactate levels in the cerebrospinal fluid decreased from 7 and 4 mmol l-1 to 2.4 and 2.6 mmol l-1 in patients 1 and 2, respectively. Thus DCA may be useful in clinical treatment of chronic congenital lactic acidosis because it seems to cross the blood-brain barrier. However, it must be given at non-toxic doses, determined by monitoring the concentrations of lactate and DCA in the blood, because orally administered DCA tends to accumulate in tissues.
Collisional-Radiative modeling of the transient excitation of a carbon atoms beam crossing a tokamak plasma edge (2014)

A time-dependent collisional-radiative (CR) model is elaborated in the purpose of modeling the penetration of an atomic carbon beam in the edge plasma of a fusion machine in order to probe it. The excited states population densities of the beam are assumed to be modified by electron-induced processes only. All momentum transfer is neglected: the penetration velocity is assumed constant. In typical conditions for the electron density and temperature gradients (∂ne/∂x ≈ 1020 m−4 and ∂Te/∂x ≈ 107 K m−1), the results illustrate the electrons efficiency to ionize the beam. With a velocity equal to 1 km s−1, the beam is ionized in 20 /is in these conditions, which corresponds to a penetration depth of 2 cm. During the conversion in ions, the atomic beam is sufficiently excited to emits spectra whose measurement in coupling with the present CR model can provide information on ∂ne/∂x and ∂Te/∂x.
Calcium sulfate: Properties and clinical applications (2008)

Calcium sulfate (CS) has enjoyed a longer history of clinical use than most currently available biomaterials. It is well-tolerated when used to fill bone defects and undergoes rapid and complete resorption without eliciting a significant inflammatory response. The raw material from which it is made is relatively inexpensive and abundant. In addition, CS can be used as a vehicle to deliver antibiotics, pharmacologic agents, and growth factors. It has found wide use in orthopedics and dentistry, and has been used in a variety of clinical applications, including the periodontal defect repair, the treatment of osteomyelitis, sinus augmentation, and as an adjunct to dental implant placement. Despite these advantages, the material has not enjoyed the popularity of many other regenerative materials, although there has been a recent resurgence of interest in the material. This review examines the properties and clinical applications of CS, with an emphasis on dental applications of the material. Limitations of the material are discussed as well as suggestions for future research.
A Survey on IoT Security: Application Areas, Security Threats, and Solution Architectures (2019)

The Internet of Things (IoT) is the next era of communication. Using the IoT, physical objects can be empowered to create, receive, and exchange data in a seamless manner. Various IoT applications focus on automating different tasks and are trying to empower the inanimate physical objects to act without any human intervention. The existing and upcoming IoT applications are highly promising to increase the level of comfort, efficiency, and automation for the users. To be able to implement such a world in an ever-growing fashion requires high security, privacy, authentication, and recovery from attacks. In this regard, it is imperative to make the required changes in the architecture of the IoT applications for achieving end-to-end secure IoT environments. In this paper, a detailed review of the security-related challenges and sources of threat in the IoT applications is presented. After discussing the security issues, various emerging and existing technologies focused on achieving a high degree of trust in the IoT applications are discussed. Four different technologies, blockchain, fog computing, edge computing, and machine learning, to increase the level of security in IoT are discussed.
Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender, and diet (2003)

Hepatic lipase (HL) plays a central role in LDL and HDL remodeling. High HL activity is associated with small, dense LDL particles and with reduced HDL2 cholesterol levels. HL activity is determined by an HL gene promoter polymorphism, by gender (lower in premenopausal women), and by visceral obesity with insulin resistance. The activity is affected by dietary fat intake and selected medications. There is evidence for an interaction of the HL promoter polymorphism with visceral obesity, dietary fat intake, and with lipid-lowering medications in determining the level of HL activity. The dyslipidemia with high HL activity is a potentially proatherogenic lipoprotein profile in the metabolic syndrome, in Type 2 diabetes, and in familial combined hyperlipidemia.
Vaccines for Moraxella catarrhalis and non-typeable Haemophilus influenzae. (2003)

The development of vaccines against non-typeable Haemophilus influenzae and Moraxella catarrhalis represents a difficult challenge. Both bacteria are mucosal surface pathogens and protection may require a mucosal immune response. In addition, the surface antigens of non-typeable Haemophilus influenzae are hypervariable and animal models of infection with these bacteria may not be predictive of human efficacy. Vaccine development has focused on conserved surface exposed antigens, including integral outer membrane proteins, pili and other attachment factors, membrane-associated proteins, and lipooligosaccharide-protein conjugates. Several vaccine candidates are described that are antigenically conserved among strains, elicit biologically functional antibodies, and have efficacy in animal models.
Thin-Film Composite Polyamide Membranes Functionalized with Biocidal Graphene Oxide Nanosheets (2013)

Fouling of membranes by microorganisms is a major limiting factor in membrane separation processes. Novel strategies are therefore required to decrease the extent of bacterial growth on membranes. In this study, we confer strong antimicrobial properties to thin-film composite polyamide membranes by a simple graphene oxide surface functionalization. Using amide coupling between carboxyl groups of graphene oxide and carboxyl groups of the polyamide active layer, graphene oxide is irreversibly bound to the membrane. Surface binding of graphene oxide is demonstrated by scanning electron microscopy and Raman spectroscopy. Direct contact of bacteria with functionalized graphene oxide on the membrane surface results in 65% bacterial inactivation after 1 h of contact time. This bactericidal effect is imparted to the membrane without any detrimental effect to the intrinsic membrane transport properties. Our results suggest that functionalization of thin-film composite membranes with graphene oxide nanosheets is a promising approach for the development of novel antimicrobial membranes.
Complete thoracoscopic S9 and/or S10 segmentectomy through a pulmonary ligament approach: a retrospective study (2023)

Complete TS of the S9, S10, and both through the PL is a reasonable option for tumors located in such segments. This approach is a feasible option for performing TS.
Field-ion scanning tunneling microscopy study of the atomic structure of 6H–SiC(0001) surfaces cleaned by in situ Si molecular beam etching (1996)

Field ion-scanning tunneling microscopy has been used to study 6H–SiC(0001) surfaces with Si adlayers on the Si-terminated surface, formed by in situ Si molecular beam etching at 950 °C. The as-cleaned surface showed a (∛×∛) reconstruction. The (2×3), (2∛×6√6), and (3×3) phases were formed by evaporating Si on this clean 6H–SiC(0001)-(∛×∛) surface. A Si(111) film 6 monolayers thick was also epitaxially grown on the 6H–SiC(0001)-(∛×∛) surface at 800 °C, and the surface exhibited the Si(111)–(7×7) reconstruction. A surface vacancy model for the (∛×∛) reconstruction is proposed, and a possible application of utilizing the various surface reconstructions to control the growth of different polytypes of SiC on the 6H–SiC substrate is discussed.
Field Comparison Tests of LDM and TDM in ATSC 3.0 (2017)

In this paper, we present laboratory and field test results of layered division multiplexing (LDM) and time division multiplexing (TDM) technologies based on Advanced Television Systems Committee 3.0. The presented field test results include analysis in several scenarios such as rooftop, indoor, and mobile receptions. In order to provide performance comparison of the LDM and TDM technologies, reception power (field strength) and successful reception rate are measured for all the considered scenarios. For in-depth analysis in real field environment, further field measurements such as threshold of visibility, marginal (minimal) reception power, and erroneous second ratio are used for rooftop, indoor, and mobile receptions, respectively. The laboratory and field test results show that the LDM technology not only shows superior performance compared to the TDM technology in all the considered scenarios (rooftop, indoor, and mobile receptions), but also enables broadcaster to efficiently provide a variety of services (e.g., mobile, pedestrian, indoor, and stationary services) with different robustness within a single radio frequency channel.
Structural insights into thermostabilization of leucine dehydrogenase from its atomic structure by cryo-electron microscopy (2018)

Leucine dehydrogenase (LDH, EC 1.4.1.9) is a NAD+-dependent oxidoreductase that catalyzes the deamination of branched-chain l-amino acids (BCAAs). LDH of Geobacillus stearothermophilus (GstLDH) is a highly thermostable enzyme that has been applied for the quantification or production of BCAAs. Here the cryo-electron microscopy (cryo-EM) structures of apo and NAD+-bound LDH are reported at 3.0 and 3.2 Å resolution, respectively. On comparing the structures, the two overall structures are almost identical, but it was observed that the partial conformational change was triggered by the interaction between Ser147 and the nicotinamide moiety of NAD+. NAD+ binding also enhanced the strength of oligomerization interfaces formed by the core domains. Such additional interdomain interaction is in good agreement with our experimental results showing that the residual activity of NAD+-bound form was approximately three times higher than that of the apo form after incubation at 80 °C. In addition, sequence comparison of three structurally known LDHs indicated a set of candidates for site-directed mutagenesis to improve thermostability. Subsequent mutation analysis actually revealed that non-conserved residues, including Ala94, Tyr127, and the C-terminal region, are crucial for oligomeric thermostability.
The Method of Integrated Pipeline Intelligent Conversion of BIM Design Model into Fine BIM Construction Model (2017)

The complexity of construction engineering and the difficulty of construction technology in our country had increased, relying on the traditional two-dimensional drawings had been unable to meet the construction process of quality management needs. In addition, because of the separation of design and construction process, the occurring of construction changes the cross construction of participating units, there is a lot of information transmission and coordination issues, which resulting in inefficient construction management. Application of BIM technology to the three-dimensional model as the carrier, the implementation of the whole life cycle of construction, which achieve a viable solution to design and construction process for multi-coordination, conflict detection, progress optimization, security management, but the integrated pipeline BIM design model can not meet the construction accuracy requirements, and the amount of information is low. Therefore, a method of intelligent conversion of BIM design model into fine BIM construction model is proposed in this paper, and standardizing BIM information to realize the application of BIM technology in the whole life cycle of construction project and effective construction guidance.
The Limits of Post-Selection Generalization (2018)

While statistics and machine learning offers numerous methods for ensuring generalization, these methods often fail in the presence of *post selection*---the common practice in which the choice of analysis depends on previous interactions with the same dataset. A recent line of work has introduced powerful, general purpose algorithms that ensure a property called *post hoc generalization* (Cummings et al., COLT'16), which says that no person when given the output of the algorithm should be able to find any statistic for which the data differs significantly from the population it came from. In this work we show several limitations on the power of algorithms satisfying post hoc generalization. First, we show a tight lower bound on the error of any algorithm that satisfies post hoc generalization and answers adaptively chosen statistical queries, showing a strong barrier to progress in post selection data analysis. Second, we show that post hoc generalization is not closed under composition, despite many examples of such algorithms exhibiting strong composition properties.
Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells (2008)

The creatine/creatine kinase system decreases drastically in sarcoma. In the present study, an investigation of catalytic activities, western blot and mRNA expression unambiguously demonstrates the prominent expression of the creatine-synthesizing enzymes l-arginine:glycine amidinotransferase and N-guanidinoacetate methyltransferase in sarcoma, Ehrlich ascites carcinoma and Sarcoma 180 cells, whereas both enzymes were virtually undetectable in normal muscle. Compared to that of normal animals, these enzymes remained unaffected in the kidney or liver of sarcoma-bearing mice. High activity and expression of mitochondrial arginase II in sarcoma indicated increased ornithine formation. Slightly or moderately higher levels of ornithine, guanidinoacetate and creatinine were observed in sarcoma compared to muscle. Despite the intrinsically low level of creatine in Ehrlich ascites carcinoma and Sarcoma 180 cells, these cells could significantly take up and release creatine, suggesting a functional creatine transport, as verified by measuring mRNA levels of creatine transporter. Transcript levels of arginase II, ornithine-decarboxylase, S-adenosyl-homocysteine hydrolase and methionine-synthase were significantly upregulated in sarcoma and in Ehrlich ascites carcinoma and Sarcoma 180 cells. Overall, the enzymes related to creatine and arginine/methionine metabolism were found to be significantly upregulated in malignant cells. However, the low levels of creatine kinase in the same malignant cells do not appear to be sufficient for the building up of an effective creatine/phosphocreatine pool. Instead of supporting creatine biosynthesis, l-arginine:glycine amidinotransferase and N-guanidinoacetate methyltransferase appear to be geared to support cancer cell metabolism in the direction of polyamine and methionine synthesis because both these compounds are in high demand in proliferating cancer cells.
ChemInform Abstract: OPTICAL AND ELECTRICAL CHARACTERIZATION OF CHEMICAL DEFECTS IN GALLIUM ARSENIDE LAYERS GROWN BY MBE (1981)

Abstract Zur Vermeidung der Inkorporation chemischer Defekte bei der Bildung von GaAs‐Schichten durch Molekularstrahl‐Epitaxie (MBE) werden die UHV‐Bedingungen sorgfältig kontrolliert.
Facilitating Initial Cell Selection in Dense Heterogeneous Network Using Mobile Speed Classification (2014)

Dense heterogeneous networks (HetNets) that comprise a number of small cells and their overlay macro cells is viewed as the solution for supporting explosive-growth user traffic in the next decade. In order to reduce the number of handovers in HetNets, the high speed mobiles should attach to the macro cells as much as possible. This paper proposes a Doppler-based Speed Classification (DSC) method for the mobiles to classify its speed into the high-speed or the low-speed classes. The classification results could be further used for the mobiles to select an appropriate cell for attaching. The DSC method is low complexity and requires no mobility-related records. Simulation results show that the DSC method is effective in broad range of scenarios.
Brute force meets Bruno force in parameter optimisation: introduction of novel constraints for parameter accuracy improvement by symbolic computation. (2011)

International audience
Schwingungsreduzierendes Lagersitzdesign durch gezielte Abstimmung der Gestaltparameter am Beispiel eines Winkelschleifers/Vibration-reducing Bearing Seat Design through Systematic Selection of the Design Parameters Using the Example of an Angle Grinder (2022)

Inhalt Die Abstimmung der Komponenten und die gezielte Beeinflussung von Schwingungen in Antriebssträngen durch die Festlegung der Gestaltparameter stellt eine Herausforderung bei der Entwicklung von Antriebssystemen dar. Ziel dieser Arbeit ist daher die gezielte Beeinflussung der radialen Schwingung des Antriebsstrangs eines Winkelschleifers durch Anpassung von Gestaltmerkmalen dessen Lagersitzes zu unterstützen. Dazu wurde der Einfluss der Gestaltmerkmale Rippenhöhe, Rippenstärke und Lagersitzabstand auf die Lagersitzsteifigkeit mit FE-Modellen ermittelt und zur Synthese einer neuen Lagersitzgestalt genutzt. Die veränderte Lagersitzgestalt wurde additiv gefertigt und die radialen Schwingungen auf einem Antriebsstrangprüfstand untersucht. Die veränderte Gestalt zeigt, im Vergleich zu einer kommerziellen Lagersitzgestalt, für eine konstante Drehzahl von 10 000 U/min geringere radiale Schwingungen. Es konnte somit gezeigt werden, dass die radialen Schwingungen eines Antriebsstrangs durch Variation der Gestaltmerkmale des Lagersitzes beeinflusst werden können.
(Invited) Evolutionary Applications of Functional Porous Silicon (2020)

Topics on the studies for enhancing the usefulness of nanostructured porous silicon (PS) are presented. The basic concept is to combine several functional properties of PS. The first is process technology to fabricate Si quantum dots (Si QDs). By the best use of the thermal, morphological, chemical, and mechanical properties of PS, colloidal Si QDs can be produced efficiently by thermal cracking alone with a sufficiently high yield. This is potentially useful for photonic and biometric applications. Based on similar merging effects, hetero-epitaxy on PS has been developed for thin ceramic film. Another is the use of thermal and structural properties by which a thermos-acoustic ultrasound emitter has been developed. Performing a broad-band emissivity, it is directly applicable to analyze the communication mechanism between mice. The last is that the combination of PS with monolayer graphene drastically improves the efficiency and the energy dispersion of the quasiballistic electron emission.