gebhart/patrepeval huggingface dataset:
Sound source localization from tactile aids for unilateral cochlear implant users (2013)

The present research asks whether two tactile aids with directional microphones, by providing additional inter-channel level information and etc., could help unilateral cochlear implant (CI) localize sound sources. For normal hearing subjects, sound source localization based on tactile vibration cues alone can be as accurate as auditory localization in the frontal horizontal plane (Gescheider, 1970). CI users may as well benefit from additional tactile aids just as normal hearing people do. The current study uses two bone-anchored hearing aids (BAHA) as sources of tactile vibration. The two BAHAs, bonded together by a special gadget to maintain a particular distance and angle, both have directional microphones, and are programed so that one point to the front-left side and the other to the front-right side. Unilateral CI users voluntarily participated in the experimental study. Wide band noise stimuli were presented at 65 dB SPL. The subjects hold one BAHA in each hand and do localization tasks with (1) CI only and (2) with CI and tactile sensation combined. Preliminary data shows CI users can get some benefit from the additional information provided by tactile aids in 360 degree localization (45 degree spacing) on the horizontal plane.
<title>Optical immersion of erythrocytes in blood: a theoretical modeling</title> (2003)

The human blood optical parameters have been calculated based on Mie theory. The calculations have been done in the spectral range from 400 nm to 1000 nm, which is of great interest due to usage of many therapeutic and diagnostic technologies. The influence of an immersion agent, like glucose, on optical properties of blood, has been studied.
Target Localization in Multi-static Passive Radar Systems with Artificial Neural Networks (2019)

We propose an artificial neural network (ANN)-based target localization method for a multi-static passive radar system consisting of multiple illuminators, a radar receiver, and a single target. Assuming a multi-frequency network, the time difference-of-arrival (TDOA) of signals coming from each illuminator via the target and direct paths is estimated from the cross-ambiguity function. The training data consists of the estimated TDOAs corresponding to all illuminators and the target locations in the training set. The performance of the ANN is then evaluated with the test data, where 10% of the total data is randomly chosen as the test data. Simulation results show that the performance of the proposed ANN-based method decreases with the increasing estimation error in TDOA. Moreover, the results show that the mean square error (MSE) performance achieved with a set of 1, 000 data points is close to that achieved with the perfect case even the signal-to-noise-ratio in the surveillance channel is - 23 dB.
Specificity of Serum Creatine Kinase Isoenzymes in Diagnosis of Acute Myocardial Infarction (1973)

A study of the diagnostic value of serum creatine kinase (CK) isoenzymes showed that MB isoenzyme, which characterizes heart tissue, was a specific and sensitive indicator of acute myocardial infarction. In cases where the clinical picture was complicated by ventricular tachycardia, severe congestive failure, shock, or resuscitation procedures heart, liver, and muscle enzymes were increased. There was also an increase in lactate dehydrogenase isoenzyme values in these cases; indeed, the only enzyme test that correlated well with electrocardiographic and necropsy findings was the MB isoenzyme.
Bovine-murine hybridoma that secretes bovine monoclonal antibody of defined specificity. (1985)

Spleen cells from a calf hyperimmunized with bovine enteric coronavirus were fused with nonproducer mouse plasmacytoma cells. Stable hybridoma lines secreting bovine immunoglobulins were obtained. One line secreted monoclonal bovine immunoglobulin G2, which reacted specifically with bovine enteric coronavirus in an enzyme-linked immunosorbent assay, inhibited virus hemagglutination, and precipitated a structural polypeptide with a molecular weight of 26,000 daltons.
Preclinical Evaluation of 68Ga-DOTA-NT-20.3: A Promising PET Imaging Probe To Discriminate Human Pancreatic Ductal Adenocarcinoma from Pancreatitis (2019)

Neurotensin receptor 1 (NTSR1) is overexpressed in human pancreatic ductal adenocarcinoma (PDAC). Specific noninvasive positron-emission tomography (PET) imaging probes may improve the diagnostic accuracy and the monitoring of therapy for patients with PDAC. Here, we report the use of the <sup>68</sup>Ga-labeled neurotensin (NTS) analogue DOTA-NT-20.3 to image human PDAC in animal models and to discriminate tumors from pancreatitis. In addition to the preclinical study, two tissue microarray slides, constructed by small core biopsies (2-5) from standard paraffin-embedded tumor tissues, were used to confirm the high (78%) positivity rate of NTSR1 expression in human PDAC. PET imaging, biodistribution, blocking, and histology studies were performed in subcutaneous AsPC-1 pancreatic tumor-bearing mice. <sup>68</sup>Ga-DOTA-NT-20.3 PET images showed rapid tumor uptake and high contrast between the tumor and background with a fast blood clearance and a moderate accumulation in the kidneys. Ex vivo biodistribution showed low uptake in normal pancreas (0.22% IA/g) and in the remaining organs at 1 h postinjection, kidney retention (5.38 ± 0.54% IA/g), and fast clearance from blood and confirmed high uptake in tumors (5.28 ± 0.93% IA/g), leading to a tumor-to-blood ratio value of 6 at 1 h postinjection. The significant decrease of tumor uptake in a blocking study demonstrated the specificity of <sup>68</sup>Ga-DOTA-N-T20.3 to target NTSR1 in vivo. PET imaging was also conducted in an orthotopic xenograft model that allows tumors to grow in their native microenvironment and in an experimental pancreatitis model generated by caerulein injections. As opposed to 2-[<sup>18</sup>F]fluoro-deoxyglucose, <sup>68</sup>Ga-DOTA-NT-20.3 distinguishes PDAC from pancreatitis. Thus, <sup>68</sup>Ga-DOTA-NT-20.3 is a promising PET imaging probe for imaging PDAC in humans.
Transparent superhydrophobic surfaces by self‐assembly of hydrophobic monolayers on nanostructured surfaces (2006)

Abstract Transparent superhydrophobic surfaces were prepared by self‐assembly of hydrophobic n‐octa‐ decyltrimethoxysilane (H 3 C(CH 2 ) 17 Si(OCH 3 ) 3 , ODS) and (3,3,3‐trifluoropropyl)trimethoxysilane (F 3 C(CH 2 ) 2 Si(OCH 3 ) 3 , FAS3) monolayers from gas phase on transparent nanoporous alumina surfaces. Water contact angles on the silylated transparent porous alumina surfaces showed a strong dependence on the dimensions of the underlying porous structure. The highest contact angle (153°) was measured on an ODS monolayer on a porous alumina surface that had a pore diameter of about 50 nm. The superhydrophobic surfaces prepared in this work are transparent and stable which widens the range of their potential applications. (© 2006 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Modifying Viterbi Algorithm to Mitigate Intertrack Interference in Bit-Patterned Media (2007)

Bit-patterned media are currently being investigated to obtain magnetic recording densities of 1 Tbit/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and more. In bit-patterned media, the adjacent tracks may be as close as adjacent bits in a track resulting in significant intertrack interference (ITI). In this work, we propose a modified trellis for the Viterbi algorithm (VA) that can mitigate the effects of ITI. Simulation results show that the modified VA improves the bit error rate. Using a simple model for track misregistration (TMR), the performance of this modified VA in the presence of TMR is also investigated. Based on the simulation results, this modified VA also appears to be more tolerant to TMR than the conventional VA
"Tert-Amino effect" in heterocyclic synthesis. Formation of N heterocycles by ring-closure reactions of substituted 2-vinyl-N,N-dialkylanilines (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT"Tert-Amino effect" in heterocyclic synthesis. Formation of N heterocycles by ring-closure reactions of substituted 2-vinyl-N,N-dialkylanilinesWillem Verboom, David N. Reinhoudt, Richard Visser, and Sybolt HarkemaCite this: J. Org. Chem. 1984, 49, 2, 269–276Publication Date (Print):January 1, 1984Publication History Published online1 May 2002Published inissue 1 January 1984https://pubs.acs.org/doi/10.1021/jo00176a011https://doi.org/10.1021/jo00176a011research-articleACS PublicationsRequest reuse permissionsArticle Views2039Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Nitrogenous glycerolipids from Ulva fasciata (Ulvaceae, Chlorophyta) of West Coast of India (2002)

Marine Algae and Marine Environment Discipline, Central Salt and Marine Chemicals Research Institute, G. B. Marg, Bhavnagar-364 002, India <em>E-mail : </em>salt@csir.res.in <em>Fax : </em>91-278-566970/567562 Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata-700 032, India <em>Manuscript received 1 June 2001, revised 18 March 2002, accepted 10 May 2002</em> An inseparable mixture of nitrogenous glycerolipids was isolated from the Dragendorff positive fraction of the methanol extract of the marine green alga <em>Ulva fasciata, </em>collected from Okha (22<sup>°</sup>28' N, 69<sup>°</sup>05' E) at Gujarat (India) coast. Monoacylglyceryl-<em>N,N,N</em>­trimethylhomoserine having 16 : 0 and 18 : 2 fatty acid residues were found to be the predominant components of this fraction. This is the first report of their occurrence in this source.
Simple conditioning with monospecific CD4+CD25+ regulatory T cells for bone marrow engraftment and tolerance to multiple gene products (2006)

A major impediment to gene replacement therapy is immune elimination of genetically modified cells. In principle, this can be dealt with by inducing a strong, specific, and enduring tolerance through engraftment of transgene-modified autologous bone marrow (BM). Because usual myeloablation and/or immunosuppression are risk factors in most pathologies, we assessed the potential of monospecific CD4(+)CD25(+) regulatory T cells (Tregs) to engraft minor-mismatched BM without preconditioning. We found that as few as 5 x 10(4) Tregs directed to the male DBY protein promote the engraftment of foreign male BM into sex-mismatched female hosts, establishing sustained chimerism in all hematopoeitic compartments. We achieved concomitantly strong tolerance to all foreign antigens expressed in the BM, likely occurring through induction of anergy and/or deletion of antidonor T cells. Chimerism was obtained in thymectomized mice too, underlining the major role of peripheral tolerance mechanisms in our system. This allowed us to engraft gene-modified tissues while preserving full immunocompetence to third-party antigens. Our results demonstrate that very few donor-specific Tregs are effective as the sole conditioning to induce mixed molecular chimerism and long-term tolerance to multiple foreign antigens.
Supplementary Table 5 from Cytogenetic and cDNA Microarray Expression Analysis of MCF10 Human Breast Cancer Progression Cell Lines (2023)

Supplementary Table 5 from Cytogenetic and cDNA Microarray Expression Analysis of MCF10 Human Breast Cancer Progression Cell Lines
Implementation of a model-based nonuniform scatter correction scheme for SPECT (1997)

In this paper four scatter-compensation schemes are considered. The four schemes are all based on a previously developed two-dimensional (2-D) scatter model. Reconstruction is achieved using the iterative expectation-maximization maximum-likelihood (EM-ML) algorithm. The schemes consist of: 1) including the model in both the forward and back projector; 2) just including the model in the forward projector; 3) and 4) implementing the model in a subtraction and addition scheme, respectively. Monte Carlo simulated projection data are used to test the accuracy, convergence properties, and noise properties of the four scatter-compensation schemes. Data are simulated for both uniformly and nonuniformly attenuating objects. The results show that all four correction schemes yield images which are similar in terms of accuracy to that obtained from reconstructing scatter-free data. The subtraction scheme is shown to converge faster than the other compensation schemes, both in terms of iterations and actual time required for reconstruction. The scheme in which the model is only used in the forward-projector and the scatter-addition scheme both performs slightly better, in terms of signal-to-noise ratio (SNR), than the subtraction scheme. However, the forward projector scheme requires significantly more CPU time for reconstruction. The correction scheme in which the scatter model was included in both the forward and backprojectors is shown to produce accurate images with SNR's higher than even a perfect scatter rejection scheme. While the scatter correction scheme with the model in both the forward projector and backprojector has superior noise properties to the other algorithms, the results suggest that the faster subtraction/addition schemes will probably prove most useful for routine clinical scatter compensation.
Fabry Disease: Percutaneous Transluminal Septal Myocardial Ablation Markedly Improved Symptomatic Left Ventricular Hypertrophy and Outflow Tract Obstruction in a Classically Affected Male (2005)

Fabry disease (alpha-galactosidase A deficiency) is an X-linked recessive lysosomal storage disease in which left ventricular hypertrophy (LVH) is common, and if severe, may mimic hypertrophic obstructive cardiomyopathy. Alcohol-induced percutaneous transluminal septal myocardial ablation (PTSMA) has been used as a safe and effective method to alleviate LVH obstruction in patients with hypertrophic obstructive cardiomyopathy (HCM). We describe a case of a classically affected Fabry 53-year-old male with symptomatic HCM (NYHA class III with exertional angina) who was treated with PTSMA. The procedure safely and effectively alleviated symptomatic left ventricular outflow tract obstruction at long-term follow-up, and the patient's NYHA classification was reduced to NYHA class I to II.
Blockchain framework for managing machine-learning models for 3D object detection (2023)

Smart monitoring plays an important role in securing people's safety in smart cities. In smart monitoring, machine-learning (ML) models are used for detecting objects in the environment, such as pedestrians and vehicles. Such ML models need to be securely managed against malicious attacks, such as tampering. This paper proposes a blockchain framework for securely managing ML models. It demonstrates the performance of a prototype of the proposed framework.
Continuously tunable singlemode VECSEL at 3.3 µm wavelength for spectroscopy (2011)

A singlemode tunable vertical external cavity surface emitting laser (VECSEL) has been realised. The VECSEL can be tuned continuously over more than 80 nm from ∼3.22 to 3.3 µm wavelength. Tuning is performed by changing the cavity length with a piezoelectric driver. Covering this wavelength range allows various potential applications, especially for gas spectroscopy of organic compounds. The VECSEL is optically pumped, and emits a maximum output power of 20 mWp when cooled with a Peltier element to −20°C. The active medium consist of PbSe quantum wells embedded in Pb1−xSrxSe (x=0.08) barrier layers and is grown on a Si-substrate.
Effects of Different Gluconacetobacter xylinus Strains on Yield and Properties of Bacterial Cellulose (2016)

Gluconacetobacter xylinus is an important bacterial cellulose (BC) producing bacterium. Effects of five strains of G. xylinus on cellulose production and properties were investigated by using D-glucose as carbon source. The initial concentration of glucose was 40 g/L. X-ray diffraction analysis, scanning electron microscopy and universal material testing machine were used to characterize the bacterial cellulose. The volume yield of bacterial cellulose by the five strains of G. xylinus was as follows: DHU-ZCY-1 (3.9 g/L) > DHU-ATCC-1 (2.62 g/L) > DHU-ZGD-1 (2.34 g/L) > DHU-YQ-1 (1.72 g/L) > ATCC23770 (0.61 g/L). The highest volume yield was around 7 times higher than the lowest one. Tensile strength of bacterial cellulose of the five strains was as follows: DHU-ZGD-1 > DHU-ZCY-1 > DHU-YQ-1 > DHU-ATCC-1 > ATCC23770. The results showed that unremarkable morphological difference of bacterial cellulose was found among the five strains. And there was no obvious difference in water content and crystallinity of BC obtained by the five strains. The fiber diameters were in the range between 65 nm and 91 nm.
1035. Use of Multi Color p27kip1 Based Flow Cytometric Assay To Evaluate and Characterize G0 to G1 Cell Cycle Related Changes in Human Hematopoietic Cells after Subjection to a Clinically Applicable Ex Vivo Transduction Protocol (2005)

In defining ex vivo cultivation strategies for human HSC gene transduction, a key factor is the responsiveness of the most primitive cells to the in vitro conditions with the aim of maintaining viability without inducing terminal differentiation. Important insights have been gained into the molecular basis of cell cycle regulating mechanisms. The major regulatory events leading to cell proliferation and differentiation occur between the G0 and G1 phases of the cell cycle, when the cell commits itself to DNA replication and both positive and negative external signals are integrated into the cell cycle. Evaluating the effect of an ex vivo transduction protocol with respect to this decisive junction between quiescence and cell division remains an elusive goal. Here, we present a novel p27kip1 flow cytometry assay which assesses the earliest molecular responses to a defined clinically applicable transduction protocol. Using p27kip1 as the main flow cytometric marker in combination with CD34 we developed methods to simultaneously assess the molecular events ongoing in individual human cord blood Lin- cells while they were cultured for 72 hours in X-Vivo 15 serum free medium supplemented with Flt3, SCF and TPO on Retronectin (RN) coated plates. The p27kip1 assay is run in four color combinations with Ki67, Cyclin A, PCNA, or CD133. To evaluate whether this protocol had the preferred effect of sustaining viability without inducing terminal differentiation we compared it to a more stimulatory extended protocol of X-Vivo 15 supplemented with SCF, Flt-3, TPO and IGF-1 on RN coated plates. p27kip1 expression in cells subjected to the basic ex vivo transduction protocol was found to be markedly high, ranging from 74.1% (T=24 Hrs) to 68.1% (T=72 Hrs.), whereas the comparable p27kip1 expression in cells subjected to the extended protocol was between 29.8% (T=24 Hrs.) and 18.8% (T=72 Hrs.). At the same time CD34 expression increased from 53.8% (T=24 Hrs.) to 80.5% (T=72 Hrs.) in the basic protocol, while the CD34 expression on cells subjected to the extended protocol was decreased from 87.5% CD34+ (T=24 Hrs.) to 73% CD34+ (T=72 Hrs.). Finally, in cultures subjected to the 72 hr. basic ex vivo transduction protocol we repeatedly found a small, but distinct population of p27kip1 expressing cells with up to 500 times more p27kip1 signal than the main population. We found this population to be 1.5%+/-0 0.3 (n=3) of the total cells in the cultures after 72 Hrs. Gating on this population showed no expression of the hematopoietic marker CD45 or the major stem/progenitor markers CD34, CD133, and CD117, indicating a highly quiescent cell type. In summary, the p27-based flow cytometric technique allows assessment of the cell cycle and differentiative status of individual hematopoietic stem and progenitor cells during periods of ex vivo culture.
Controlled Sensing for Sequential Multihypothesis Testing with Controlled Markovian Observations and Non-Uniform Control Cost (2015)

Abstract A new model for controlled sensing for multihypothesis testing is proposed and studied in the sequential setting. This new model, termed a controlled Markovian observation model, exhibits a more complicated memory structure in the controlled observations than existing models. In addition, instead of penalizing just the delay until the final decision time as in standard sequential hypothesis testing problems, a much more general cost structure is considered that entails accumulating the total control cost with respect to an arbitrary control cost function. An asymptotically optimal test is proposed for this new model and is shown to satisfy an optimality condition formulated in terms of decision-making risk. It is shown that the optimal causal control policy for the controlled sensing problem is self-tuning, in the sense of maximizing an inherent “inferential” reward simultaneously under every hypothesis, with the maximal value being the best possible corresponding to the case where the true hypothesis is known at the outset. Another test is also proposed to meet distinctly predefined constraints on the various decision risks nonasymptotically, while retaining asymptotic optimality.
Endothelin Stimulates Glucose Uptake and GLUT4 Translocation via Activation of Endothelin ETA Receptor in 3T3-L1 Adipocytes (1999)

Endothelin-1 (ET-1) is a 21-amino acid peptide that binds to G-protein-coupled receptors to evoke biological responses. This report studies the effect of ET-1 on regulating glucose transport in 3T3-L1 adipocytes. ET-1, but not angiotensin II, stimulated glucose uptake in a dose-dependent manner with an EC50 value of 0.29 nM and a 2.47-fold stimulation at 100 nM. ET-1 stimulated glucose uptake in differentiated 3T3-L1 cells but had no effect in undifferentiated cells, although ET-1 stimulated phosphatidylinositol hydrolysis to a similar degree in both. The 3T3-L1 cells expressed approximately 560,000 sites/cell of ETA receptor, which was not altered during differentiation. Western blot analysis and immunofluorescence staining show that ET-1 stimulated the translocation of insulin-responsive aminopeptidase and GLUT4 to the plasma membrane. The effect of ET-1 on glucose uptake was blocked by A-216546, an antagonist selective for the ETA receptor. ET-1 treatment did not induce phosphorylation of insulin receptor beta-subunit, insulin receptor substrate-1, or Akt but stimulated the tyrosyl phosphorylation of a 75-kDa protein. Genistein (100 microM), an inhibitor of tyrosine kinases, inhibited ET-1-stimulated glucose uptake. Our results show that ET-1 stimulates GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes via activation of ETA receptor.