gebhart/patrepeval huggingface dataset:
High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells (2016)

Current chemotherapies for T cell acute lymphoblastic leukemia (T-ALL) efficiently reduce tumor mass. Nonetheless, disease relapse attributed to survival of preleukemic stem cells (pre-LSCs) is associated with poor prognosis. Herein, we provide direct evidence that pre-LSCs are much less chemosensitive to existing chemotherapy drugs than leukemic blasts because of a distinctive lower proliferative state. Improving therapies for T-ALL requires the development of strategies to target pre-LSCs that are absolutely dependent on their microenvironment. Therefore, we designed a robust protocol for high-throughput screening of compounds that target primary pre-LSCs maintained in a niche-like environment, on stromal cells that were engineered for optimal NOTCH1 activation. The multiparametric readout takes into account the intrinsic complexity of primary cells in order to specifically monitor pre-LSCs, which were induced here by the SCL/TAL1 and LMO1 oncogenes. We screened a targeted library of compounds and determined that the estrogen derivative 2-methoxyestradiol (2-ME2) disrupted both cell-autonomous and non-cell-autonomous pathways. Specifically, 2-ME2 abrogated pre-LSC viability and self-renewal activity in vivo by inhibiting translation of MYC, a downstream effector of NOTCH1, and preventing SCL/TAL1 activity. In contrast, normal hematopoietic stem/progenitor cells remained functional. These results illustrate how recapitulating tissue-like properties of primary cells in high-throughput screening is a promising avenue for innovation in cancer chemotherapy.
Efficacy and side effects of radiation therapy in comparison with radiation therapy and temozolomide in the treatment of measurable canine malignant melanoma (2014)

Abstract Prognosis for unresectable canine malignant melanoma ( MM ) is typically poor, and therapeutic approaches remain largely palliative. A bi‐institutional trial was conducted to compare efficacy and safety of radiation therapy ( RT ) and RT with post‐radiation temozolomide in dogs with chemotherapy‐naïve, measurable MM . RT consisted of 5 × 6 Gy fractions over 2.5 weeks. Dogs whose owners wished to pursue chemotherapy received adjuvant oral temozolomide (60 mg m −2 for 5 days every 28 days). Fifteen dogs were treated with RT only (Group 1) and 12 dogs subsequently received temozolomide (Group 2). Overall response rate was similar between Group 1 (86.7%) and Group 2 (81.1%). Median time to progression ( TTP ) was significantly longer in Group 2 (205 days) compared to Group 1 (110 days; p = 0.046). Survival time was not significantly different between groups. Both treatments were well tolerated. Post‐radiation temozolomide has a good safety profile, and may improve TTP in MM when compared to coarse fractionated RT .
[Appropriateness criteria for the management of anticoagulant therapy in complex patients with atrial fibrillation. The opinion of a group of expert Italian cardiologists]. (2018)

Atrial fibrillation (AF) is a common arrhythmia often associated with high thromboembolic risk. The purpose of this position paper is to provide clinicians with recommendations useful in managing some important issues regarding the use of anticoagulant therapy in patients with AF in particularly complex clinical situations.The RAND/UCLA appropriateness method, validated to combine the best available scientific evidence with the collective judgment of experts, was used to assess the judgment of an expert panel of cardiologists. To this purpose, the benefit-to-harm ratio of 37 clinical scenarios was rated. Each indication was classified as "appropriate", "uncertain", or "inappropriate" in accordance with the panelists' median score.The present document reports the results of this consensus process, which led to the development of recommendations for clinical practice on how to use anticoagulant therapy in patients with AF in complex clinical settings, including the presence of comorbidities, cardioversion, or ablation. Non-vitamin K oral anticoagulants are a valid alternative to vitamin K antagonists in preventing embolic events in patients with non-valvular AF, particularly in case of clinical complexity.
A quasi-convex optimization approach to parameterized model order reduction (2005)

In this paper an optimization based model order reduction (MOR) framework is proposed. The method involves setting up a quasi-convex program that explicitly minimizes a relaxation of the optimal H/sub /spl infin// norm MOR problem. The method generates guaranteed stable and passive reduced models and it is very flexible in imposing additional constraints. The proposed optimization approach is also extended to parameterized model reduction problem (PMOR). The proposed method is compared to existing moment matching and optimization based MOR methods in several examples. A PMOR model for a large RF inductor is also constructed.
Transjurisdictional Water Pollution Management: The Huai River Example (2004)

Abstract Transjurisdictional water pollution has been a major problem for Chinese authorities due to legal, institutional, and procedural frameworks that are inadequate to deal with integrated water resources management or for resolving local and inter-provincial disputes. The pollution crisis in 1994 in the Huai River was of such severity that the State Council directly intervened and promulgated new legal and institutional approaches to deal with this transjurisdictional crisis. This included a new regulation with new procedures, new institutional arrangements, and specific measures to deal with polluters. The Huai River example provides a background for how transjurisdictional pollution might be managed elsewhere in China and on the continuing problems in Chinese transjurisdictional pollution management. The example of the Huai River basin demonstrates typical problems of environmental governance in China and illustrates the directions that the Chinese Government is taking to resolve these.
Field-induced lattice transformation of blue-phase liquid crystals (2021)

Under an applied electric field, BPLC lattice undergoes with complex reconfiguration dynamics and exhibit meta-stability and new crystal symmetries. Detailed theoretical considerations and experimental results with such Repetitively Applied Field (RAF)Technique for transforming BPLC crystalline lattice structures from cubic to final stable configuration with orthorhombic or tetragonal symmetry will be presented.
Direct Observation of Disrotatory Ring-Opening in Photoexcited Cyclobutene Using ab Initio Molecular Dynamics (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDirect Observation of Disrotatory Ring-Opening in Photoexcited Cyclobutene Using ab Initio Molecular DynamicsM. Ben-Nun and Todd J. MartínezView Author Information Department of Chemistry and The Beckman Institute University of Illinois, Urbana, Illinois 61801 Cite this: J. Am. Chem. Soc. 2000, 122, 26, 6299–6300Publication Date (Web):June 17, 2000Publication History Received20 December 1999Revised28 April 2000Published online17 June 2000Published inissue 1 July 2000https://pubs.acs.org/doi/10.1021/ja9943896https://doi.org/10.1021/ja9943896rapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views315Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Butadiene,Computational chemistry,Hybridization,Molecules,Resonance structures Get e-Alerts
Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells (2015)

Our in vitro findings suggest that targeting ADAM-17 with D1(A12) may have anticancer activity in TNBC cells.
Mexiletine and Disopyramide Suppress Ventricular Premature Contractions(VPC) Irrespective of the Relationship between the VPC and the Underlying Heart Rate. (1992)

The effects of mexiletine (300 mg/day, 24 patients) and disopyramide (300 mg/day, 20 patients) on ventricular premature contractions (VPCs) were studied using a 24-hour ambulatory electrocardiogram. The VPC frequency was evaluated as a function of the underlying heart rate (HR). The VPC-HR correlation was classified into 2 major types, depending on whether the frequency of the VPC increased with the increased HR (positive type) or not (nonpositive type). The effects of the drugs were assessed based on the VPC-HR correlation and on the percent reduction of the VPC frequency. Mexiletine and disopyramide significantly decreased the frequency of the VPCs of both the positive and nonpositive types. Each drug was assumed to be effective when the percent reduction of the VPC frequency exceeded 70%. Mexiletine (300 mg/day) was 58.5% effective in positive type patients and 33.3% effective in nonpositive type patients, with a total efficacy of 45.8%. Disopyramide was effective in 50% of total cases with 44.4% in positive type patients and 54.5% in nonpositive type patients. However, the efficacy of these drugs on the 2 different types of VPCs was the same statistically. The findings strikingly contrasted those obtained with diltiazem and atenolol, which predominantly suppressed VPCs of the positive type which share similar characteristics with a triggered activity in vitro. We conclude that the mode of action of class I antiarrhythmics on the VPCs differs from that of class II or IV antiarrhythmics, as viewed from the VPC-HR relationship, and that the difference probably comes from the different arrhythmogenesis for positive and nonpositive types of VPCs, in addition to the different electrophysiological actions of mexiletine and disopyramide.
Cardiovascular morphogenesis in zebrafish (1996)

Much of our current understanding of early vertebrate cardiovascular development has come from study of avian and amphibian embryos (for a review of classical work on early specification of the heart, see Ref. [l]). The physical accessibility of these embryos and their developing cardiovascular tissues has made it possible to begin to examine the inductive interactions leading to heart formation. However, these organisms are relatively intractable to genetic analysis. Genetic screens have been instrumental in providing the tools to dissect complex developmental processes in invertebrates such as Drosophila melanogaster and C. elegans [2,3], but vertebrates more amenable to genetic analysis, notably the mouse, have embryos that develop inside the mother and are relatively inaccessible to observation and experimental manipulation, precluding screening for mutations affecting cardiovascular development. The zebrafish, Danio rerio, is a small tropical freshwater cyprinid with an approximately 3-month generation time. Adult fish measure approximately 1.5 inches in length, allowing large numbers of fish to be maintained economically in a relatively small space (Fig. 1A). Females produce several hundred eggs at frequent intervals, and the eggs are externally fertilized, so embryos are available for observation and experimental manipulation at all stages. In addition, the embryos are optically transparent until relatively late in embryogenesis, making it possible to observe development of internal organs directly and non-invasively (Fig. lC>. We have begun to explore whether the zebrafish might serve as a tractable model system for a combined embryologic and genetic analysis of cardiovascular development. In this review we describe particulars of the developing cardiovascular system in zebrafish and experimental and genetic methods that have been or could be applied to its study, and we illustrate the similarity of early cardiovascular development in zebrafish to that of mammals.
Expression ofHoxa-1 andHoxb-7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells. J Cell Biochem 69:377–391. (1998)

Srebrow A, Friedmann Y, Ravanpay A, Daniel CW, Bissell MJ (1998): Expression of Hoxa-1 and Hoxb-7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells. J Cell Biochem 69:377–391. In Figure 3 on pages 384 and Figure 4 on page 385, two labels were misprinted. The top label on the right side of Figure 3B should have been Hoxb-7 instead of Hoxb-1, and the center label of Figure 4B should have been Hoxb-7 instead of Hoxa-7. The corrected figures are reprinted on the following pages. The Publisher apologizes for the error.
Detection of Machine Tool Anomalies from Bayesian Changepoint Recurrence Estimation (2019)

In this study, we consider the problem of detecting process-related anomalies for machine tools. The similar shape of successive sensor signals, which arises due to the same process step sequence applied to each workpiece, suggests extracting shape-related features. In recent years, shapelets dominated the field of shape-related features. Unfortunately, they involve a high computational burden due to hyperparameter optimization.We introduce alternative shape-related features relying on abrupt signal changes (changepoints) reflecting the changes of process steps. During normal operation, changepoints follow a highly recurrent pattern, i.e., appear at similar locations. Thus, being able to distinguish regular, recurrent from abnormal, non-recurrent changepoints allows detecting process anomalies.For changepoint recurrence estimation, we extend the Bayesian Online Changepoint Detection (BOCPD) method. The extension allows distinguishing normal and abnormal changepoints relying on empirical estimates of the changepoint recurrence distribution. Subsequently, changepoint-related features are introduced and compared to shapelets and wavelet-based features in a case study comprising real-world machine tool data.Qualitative results verify changepoint locations being comparable to shapelet locations found by the FLAG shapelet approach. Furthermore, quantitative results suggest superior classification performance both to shapelets and wavelet-based features.
Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin (2017)

The cellular serine protease TMPRSS2, a member of the type II transmembrane serine protease (TTSP) family, cleaves and activates the hemagglutinin of influenza A viruses (FLUAV) in cell culture and is essential for spread of diverse FLUAV in mice. Non-human primates (NHP), in particular rhesus and cynomolgus macaques, serve as animal models for influenza and experimental FLUAV infection of common marmosets has recently also been reported. However, it is currently unknown whether the NHP orthologues of human TMPRSS2 cleave and activate FLUAV hemagglutinin and contribute to viral spread in respiratory tissue. Here, we cloned and functionally analyzed the macaque and marmoset orthologues of human TMPRSS2. In addition, we analyzed the macaque orthologues of human TMPRSS4 and HAT, which also belong to the TTSP family. We found that all NHP orthologues of human TMPRSS2, TMPRSS4 and HAT cleave and activate HA upon directed expression and provide evidence that endogenous TMPRSS2 is expressed in the respiratory epithelium of rhesus macaques. Finally, we demonstrate that a serine protease inhibitor active against TMPRSS2 suppresses FLUAV spread in precision-cut lung slices of human, macaque and marmoset origin. These results indicate that FLUAV depends on serine protease activity for spread in diverse NHP and in humans. Moreover, our findings suggest that macaques and marmosets may serve as models to study FLUAV activation by TMPRSS2 in human patients.
Do Mitochondria make Nitric Oxide? No? (2004)

Several papers have claimed that mitochondria contain nitric oxide synthase (NOS) and make nitric oxide (NO*) in amounts sufficient to affect mitochondrial respiration. However, we found that the addition of L-arginine or the NOS inhibitor L-NMMA to intact rat liver mitochondria did not have any effect on the respiratory rate in both State 3 and State 4. We did not detect mitochondrial NO* production by the oxymyoglobin oxidation assay, or electrochemically using an NO* electrode. An apparent NO* production detected by the Griess assay was identified as an artifact. NO* generated by eNOS added to the mitochondria could easily be detected, although succinate-supplemented mitochondria appeared to consume NO*. Our data show that NO* production by normal rat liver mitochondria cannot be detected in our laboratory, even though the levels of production claimed in the literature should easily have been measured by the techniques used. The implications for the putative mitochondrial NOS are discussed.
Phantom Validation of Multichannel Magnetocardiography Source Localization (2003)

Multichannel magnetocardiography (MMCG) is used clinically for noninvasive localization of the site of origin of cardiac arrhythmias. However, its accuracy in unshielded environments is still unknown. The aim of this study was to test the accuracy of three-dimensional localization of intracardiac sources by means of MMCG in an unshielded catheterization laboratory using a saline-filled phantom, together with a nonmagnetic catheter designed for multiple monophasic action potential recordings in a clinical setting. A nine-channel direct current superconducting quantum interference device (DC-SQUID) system (sensitivity fT/Hz0.5) was used for MMCG from 36 points in a measuring area of 20 x 20 cm. The artificial sources to be localized were dipoles embedded in the distal end of the catheter, placed 12 cm below the sensor's plane. Equivalent current dipoles, effective magnetic dipoles, and distributed currents models were used for the inverse solution. The localization error was estimated as the three-dimensional difference between the physical position of the tip of the catheter and the three-dimensional localization of the dipoles derived by means of the inverse solution calculated from MMCG data. The reproducibility was tested by repeating the MMCG after repositioning the phantom and the measurement system. The average location error of the catheter dipole was 9 +/- 4 mm and was due primarily to imprecise depth estimation. Localization was reproducible within 0.73 mm. The distributed currents model provided an accurate image of current distribution centered over the catheter tip. The authors conclude that MMCG estimation is accurate enough to guarantee proper localization of cardiac dipolar sources even in an unshielded clinical electrophysiological laboratory.
Trustware: A Device-based Protocol for Verifying Client Legitimacy (2017)

Online services commonly attempt to verify the legitimacy of users with CAPTCHAs. However, CAPTCHAs are annoying for users, often difficult for users to solve, and can be defeated using cheap labor or, increasingly, with improved algorithms. We propose a new protocol for clients to prove their legitimacy, allowing the client's devices to vouch for the client. The client's devices, and those in close proximity, provide a one-time passcode that is verified by the device manufacturer. This verification proves that the client has physical access to expensive and trusted devices, vouching for the client's legitimacy.
Kelvin test structure for measuring contact resistance of shallow junctions (2002)

A Kelvin contact resistance test structure has been developed for accurate and direct measurement of highly-doped shallow n/sup +/ and p/sup +/ junctions, which may be self-aligned to the contact window. The structure is easily integrated in many IC-processes. Results are presented for high-dose arsenic implantations, where excimer laser annealing of the contact windows yields contact resistivities below 10/sup -7/ /spl Omega/cm/sup 2/.
3D‐Printed Autonomous Sensory Composites (2017)

A method for 3D-printing autonomous sensory composites requiring no external processing is presented. The composite operates at 1.5 V, locally performs active signal transduction with embedded electrical gain, and responds to stimuli, reversibly transducing mechanical strain into a transparency change. Digital assembly of spatially tailored solids and thin films, with encapsulated liquids, provides a route for realizing complex autonomous systems.
The Growth of Ice Layers on the Surfaces of Anatase and Silver Iodide (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Growth of Ice Layers on the Surfaces of Anatase and Silver IodideF. E. Karasz, W. M. Champion, and G. D. Halsey Jr.Cite this: J. Phys. Chem. 1956, 60, 3, 376–378Publication Date (Print):March 1, 1956Publication History Published online1 May 2002Published inissue 1 March 1956https://pubs.acs.org/doi/10.1021/j150537a033https://doi.org/10.1021/j150537a033research-articleACS PublicationsRequest reuse permissionsArticle Views34Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts