gebhart/patrepeval huggingface dataset:
Genetic Ablation of Caveolin‐1 does not Affect Pressure‐Induced Constriction but Alters Endothelin‐1 Pharmacology in Murine Cerebral Arteries (2008)

Numerous phenotypic changes have been reported in mice with knockout of caveolin‐1 (KO) expression. This study evaluated cerebroarterial reactivity to investigate the role of caveolin‐1 in vascular smooth muscle function. Arterial segments were isolated from KO and wild type (WT) mice of age 6–9 months, pressure‐mounted and diameter was monitored. No difference was observed in constriction to intraluminal pressure up to 110 mmHg, further increase in pressure caused forced dilation. Constrictions to 60 mM KCl, 10 μM phenylephrine and 10 μM serotonin and dilation to 10 μM bradykinin and 16mM KCl were not different in WT and KO arteries. Concentration response curves to endothelin‐1 in WT arteries were biphasic. In KO arteries, constriction to ET1 was significantly decreased and the second low affinity phase was not observed. Decreased ET1 constriction was not restored by 100 μM L‐NAME. Myogenic tone at 70 mmHg was reversed by SKF 96365 and 2APB, known blockers of transient receptor potential (TRP) channels, in WT but only partially decreased in KO arteries. ET1 constriction was equally sensitive to SKF 96365 and 2APB in both groups. Myogenic tone was reversed by Y27632, a rho‐kinase inhibitor in both groups. Decrease in ET1 constriction by Y27632 was significantly lower in KO arteries compared to WT arteries. Constriction to pressure and ET1 may be modulated by caveolin‐1 via activation of TRP channels and rho‐kinase.
Localization of the neurons active during paradoxical (REM) sleep and projecting to the locus coeruleus noradrenergic neurons in the rat (2006)

Locus coeruleus (LC) noradrenergic neurons are active during wakefulness, slow their discharge rate during slow wave sleep, and stop firing during paradoxical sleep (PS). A large body of data indicates that their inactivation during PS is due to a tonic GABAergic inhibition. To localize the neurons responsible for such inhibition, we first examined the distribution of retrogradely and Fos double-immunostained neurons following cholera toxin b subunit (CTb) injection in the LC of control rats, rats selectively deprived of PS for 3 days, and rats allowed to recover for 3 hours from such deprivation. We found a significant number of CTb/Fos double-labeled cells only in the recovery group. The largest number of CTb/Fos double-labeled cells was found in the dorsal paragigantocellular reticular nucleus (DPGi). It indeed contained 19% of the CTb/Fos double-labeled neurons, whereas the ventrolateral periaqueductal gray (vlPAG) contained 18.3% of these neurons, the lateral paragigantocellular reticular nucleus (LPGi) 15%, the lateral hypothalamic area 9%, the lateral PAG 6.7%, and the rostral PAG 6%. In addition, CTb/Fos double-labeled cells constituted 43% of all the singly CTb-labeled cells counted in the DPGi compared with 29% for the LPGi, 18% for the rostral PAG, and 10% or less for the other structures. Although all these populations of CTb/Fos double-labeled neurons could be GABAergic and tonically inhibit LC neurons during PS, our results indicate that neurons from the DPGi constitute the best candidate for this role.
Solubilization of wheat gluten with sodium hydroxide (1981)

Abstract The solubility of wheat gluten may be increased greatly by treatment with 0.25 M sodium hydroxide. At temperatures of 40°C and above, the solubility of the protein exceeds 100 mg/ml in a reaction time of 6 hr or less. The products from the reaction of 60°C and 80°C were darker than the original gluten and had an unpleasant odour of H2S on dissolution in water. They also contained traces of lysinoalanine. The 40°C reaction product was about the same colour as gluten, and its solutions in water did not smell of H2S. Reaction of gluten at 20°C also caused a large increase in solubility, but after 24 hr the solubility was only 77 mg/ml. This product was also of the same colour as gluten, and did not smell of H2S in solution. Neither the 20°C nor the 40°C products contained detectable traces of lysinoalanine. For reasons of flavour, colour, lysinoalanine content and economy of time, the optimum reaction conditions are 6 hr at 40°C.
Emerging role of novel biomarkers in the diagnosis of inflammatory bowel disease (2016)

There is currently no gold standard test for the diagnosis of inflammatory bowel disease (IBD). Physicians must rely on a number of diagnostic tools including clinical and endoscopic evaluation as well as histologic, serologic and radiologic assessment. The real difficulty for physicians in both primary and secondary care is differentiating between patients suffering from functional symptoms and those with true underlying IBD. Alongside this, there is always concern regarding the possibility of a missed, or delayed diagnosis of ulcerative colitis (UC) or Crohn's disease. Even once the diagnosis of IBD has been made, there is often uncertainty in distinguishing between cases of UC or Crohn's. As a consequence, in cases of incorrect diagnosis, optimal treatment and management may be adversely affected. Endoscopic evaluation can be uncomfortable and inconvenient for patients. It carries significant risks including perforation and in terms of monetary cost, is expensive. The use of biomarkers to help in the diagnosis and differentiation of IBD has been increasing over time. However, there is not yet one biomarker, which is sensitive of specific enough to be used alone in diagnosing IBD. Current serum testing includes C-reactive protein and erythrocyte sedimentation rate, which are cheap, reliable but non-specific and thus not ideal. Stool based testing such as faecal calprotectin is a much more specific tool and is currently in widespread clinical use. Non-invasive sampling is of the greatest clinical value and with the recent advances in metabolomics, genetics and proteomics, there are now more tools available to develop sensitive and specific biomarkers to diagnose and differentiate between IBD. Many of these new advances are only in early stages of development but show great promise for future clinical use.
Enhanced Diversity-Achieving Quadrature Spatial Modulation With Fast Decodability (2020)

In this paper, based on the architecture of diversity-achieving quadrature spatial modulation (DA-QSM) transmission scheme, we propose an Enhanced DA-QSM (EDA-QSM) scheme. In the proposed EDA-QSM scheme, by using Kronecker product extension to the eight dispersion matrices of Sezginer-Sari-Biglieri (SSB) code, the size of the dispersion matrices set is doubled compared with DA-QSM. Consequently, EDA-QSM is shown to have higher spectral efficiency as well as nonvanishing determinant (NVD) property without requiring any parameter optimization. Furthermore, EDA-QSM with an appropriate ordering of the dispersion matrices is a block-orthogonal space-time code (BOSTC), which then makes the four real variables corresponding to the same block are independent and orthogonal. By utilizing this feature, for the detection of EDA-QSM we propose a state codewords matched block-by-block sphere decoding (SD) algorithm, which significantly decreases the decoding complexity of ML decoder. Simulation results of bit error rate (BER) performance show that the new EDA-QSM scheme outperforms some newly presented diversity-achieving SM schemes.
ChemInform Abstract: A New One‐Pot Synthesis of Bisperfluoroalkanesulfonylamides and Bispentafluorobenzenesulfonylamide as Potassium Salts. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Studies on the Propylene Glycol Alginate for the Cultured Milk Drinks Stabilizer. Part I. (1963)

[in Japanese]
Order-disorder transition of vortex matter in Mg0.9B2: anisotropic effects (2009)

Third-harmonic susceptibility studies have been employed to probe the order-disorder transition of Vortex Matter of a magnesium-deficient sample of MgB2. Our results reveal that the measured threshold is anisotropic for different orientations of the applied magnetic field, suggesting that the pinning efficiency of the magnesium-deficient regions depend on the orientation of the penetrated vortices.
Graphene/Al2O3/Graphene heterojunction for Light emitting tunneling diode (2019)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text H. Kang, R. Maiti, R. Hemnani, M. Miscuglio, and V. Sorger, "Graphene/Al2O3/Graphene heterojunction for Light emitting tunneling diode," in Frontiers in Optics + Laser Science APS/DLS, OSA Technical Digest (Optica Publishing Group, 2019), paper JW4A.13. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Co-training with a Single Natural Feature Set Applied to Email Classification (2004)

When dealing with information overload from the Internet, such as the classification of Web pages and the filtering of email spam, a new technique called co-training has been shown to be a promising approach to help build more accurate classifiers. Co-training allows classifiers to learn with fewer labelled documents by taking advantage of the more abundant unclassified documents. However, conventional co-training requires the dataset to be described by two disjoint and natural feature sets that are sufficiently redundant. In many practical situations, it is not intuitively obvious how to obtain two natural feature sets. This paper shows that when only a single natural feature set is used, the performance of co-training is beneficial in the application of email classification.
Host cell-dependent regulation of growth transformation-associated Epstein-Barr virus antigens in somatic cell hybrids (1989)

We have analyzed the expression of the three major known growth transformation-associated Epstein-Barr virus (EBV) proteins, EBNA-1, EBNA-2, and latent membrane protein (LMP), in a series of somatic cell hybrids derived from the fusion of EBV-carrying Burkitt lymphoma (BL) lines with EBV-positive or EBV-negative B-cell lines. Independently of the cell phenotype, EBNA-1 was invariably coexpressed in all EBV-carrying hybrids. In hybrids between EBV-carrying, LMP-positive and LMP-negative Burkitt lymphoma lines, LMP was expressed, indicating positive control. Two EBV-negative lymphoma lines, Ramos and BJAB, differed in their ability to express LMP after B95-8 virus-induced conversion and after hybridization with Raji cells. BJAB was permissive while Ramos was nonpermissive for LMP, although both expressed EBNA-2. The EBNA-2-deleted P3HR-1 virus gave the same pattern of LMP expression in these two cells. Our findings indicate that the expression of EBNA-1, EBNA-2, and LMP is regulated by independent mechanisms.
Solubilization of Rock Phosphates by Alginate Immobilized Cells of Pantoea agglomerans (2005)

Pantoea agglomerans immobilized in alginate solubilized four different rock phosphates efficiently under in vitro conditions. The solubilization pattern differed according to the rock phosphate source, where maximum solubilization of Morocco and Tunisia rock phosphates (215.6 and ) on 6 days, Israel rock phosphate () and tricalcium phosphate () on 10 days and China rock phosphate () on 12 days after inoculation was observed. The shelf life of the immobilized bacteria immobilized beads stored in two different temperatures was studied for six months. Beads stored at both room temperature as well as cold storage () were found equally good in supporting the bacterial population as well as phosphate solubilizing activity. P. agglomerans immobilized in alginate might be exploited for large scale biosolubilization of rock phosphates intended for fertilizer use.
Multibody simulation of a freight bogie with friction dampers (2004)

Freight bogies are often built using a friction element instead of viscous dampers with great advantage regarding cost and maintainability. On the other hand this technical choice leads to low performance of the vehicle. The aim of this work is to evaluate the behaviour of a Y25 freight bogie that is the most diffuse in Europe where friction dampers are used to reduce vertical and hunting vibrations. The purpose is also to improve a bi-dimensional model of friction damper and to test its numerical efficiency on a whole vehicle model in a multibody code.
Why you should care about quantile regression (2013)

Research has shown that correctly conducting and analysing computer performance experiments is difficult. This paper investigates what is necessary to conduct successful computer performance evaluation by attempting to repeat a prior experiment: the comparison between two Linux schedulers. In our efforts, we found that exploring an experimental space through a series of incremental experiments can be inconclusive, and there may be no indication of how much experimentation will be enough. Analysis of variance (ANOVA), a traditional analysis method, is able to partly solve the problems with the previous approach, but we demonstrate that ANOVA can be insufficient for proper analysis due to the requirements it imposes on the data. Finally, we demonstrate the successful application of quantile regression, a recent development in statistics, to computer performance experiments. Quantile regression can provide more insight into the experiment than ANOVA, with the additional benefit of being applicable to data from any distribution. This property makes it especially useful in our field, since non-normally distributed data is common in computer experiments.
Online feature selection using grafting (2003)

In the standard feature selection problem, we are given a fixed set of candidate features for use in a learning problem, and must select a subset that will be used to train a model that is &amp;quot;as good as possible&amp;quot; according to some criterion. In this paper, we present an interesting and useful variant, the online feature selection problem, in which, instead of all features being available from the start, features arrive one at a time. The learner&amp;apos;s task is to select a subset of features and return a corresponding model at each time step which is as good as possible given the features seen so far. We argue that existing feature selection methods do not perform well in this scenario, and describe a promising alternative method, based on a stagewise gradient descent technique which we call grafting.
Trimeric structure of human proliferating cell nuclear antigen. Implications for enzymatic function and autoantibody recognition. (1994)

The proliferating cell nuclear Ag (PCNA) is a DNA replication factor postulated to function as a sliding clamp around DNA. PCNA is also a target for autoimmunity in systemic lupus erythematosus. The autoantigenicity of PCNA is highly conformation-dependent, and reaction with most anti-PCNA sera requires a nearly full-length PCNA molecule. Here we describe the use of gel filtration and glycerol gradient sedimentation to analyze the native structure and size of PCNA. PCNA from three sources was studied (PCNA from HeLa cells, PCNA purified after its overexpression in bacteria, and PCNA produced in the wheat germ cell-free translation system) as well as mutant forms of PCNA translated in vitro. In each case, full-length PCNA behaved as a trimer. Analysis of mutant proteins revealed a correlation between the trimeric form and binding to the common type of human anti-PCNA autoantibody, suggesting that the Abs are specific for the active form of the protein. These findings are consistent with the idea that autoantibodies are generated as a response to native Ag and provide experimental support for the hypothesis that PCNA serves its processive function in DNA replication as a trimeric ring structure.
Inhibition of the Akt/PKB Kinase Increases Nav1.6-Mediated Currents and Neuronal Excitability in CA1 Hippocampal Pyramidal Neurons (2022)

In neurons, changes in Akt activity have been detected in response to the stimulation of transmembrane receptors. However, the mechanisms that lead to changes in neuronal function upon Akt inhibition are still poorly understood. In the present study, we interrogate how Akt inhibition could affect the activity of the neuronal Na<sub>v</sub> channels with while impacting intrinsic excitability. To that end, we employed voltage-clamp electrophysiological recordings in heterologous cells expressing the Na<sub>v</sub>1.6 channel isoform and in hippocampal CA1 pyramidal neurons in the presence of triciribine, an inhibitor of Akt. We showed that in both systems, Akt inhibition resulted in a potentiation of peak transient Na+ current (<i>I</i><sub>Na</sub>) density. Akt inhibition correspondingly led to an increase in the action potential firing of the CA1 pyramidal neurons that was accompanied by a decrease in the action potential current threshold. Complementary confocal analysis in the CA1 pyramidal neurons showed that the inhibition of Akt is associated with the lengthening of Na<sub>v</sub>1.6 fluorescent intensity along the axonal initial segment (AIS), providing a mechanism for augmented neuronal excitability. Taken together, these findings provide evidence that Akt-mediated signal transduction might affect neuronal excitability in a Na<sub>v</sub>1.6-dependent manner.
High hole mobility front-gate InAs/InGaSb-OI single structure CMOS on Si (2015)

We have demonstrated the front-gate (FG) III-V single structure CMOS using ultra-thin body (UTB) InAs/InGaSb on insulator (-OI) on Si substrates with high hole mobility (μ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">eff</sub> ) of 240 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> V <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> s <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> . We have found that the μ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">eff</sub> is enhanced by the buffered-HF (BHF)-cleaned InAs MOS interfaces, Ni alloy S/D, and the InAs/strained InGaSb-OI hetero-interface channel. The CMOS operation using FG InAs/InGaSb-OI n/p-MOSFETs has been realized.
Proteomic Analysis Reveals Field-Wide Changes in Protein Expression in the Morphologically Normal Mucosa of Patients with Colorectal Neoplasia (2006)

Models for the pathogenesis of colorectal cancer tend to focus on the localized lesion, with less attention paid to changes in normal-appearing mucosa. Here we used two-dimensional gel electrophoresis and mass spectrometry to define patterns of protein expression in morphologically normal colonic mucosa from 13 healthy subjects, 9 patients with adenomatous polyps, and 9 with cancer. Tumor samples were also compared with the normal mucosa. Systematic gel comparisons identified a total of 839 spots that differed significantly between one or more groups (P < 0.05). Principle component analysis indicated that the first three components accounted for approximately 37% of the total variation and provided clear evidence that flat mucosa from healthy subjects differed significantly from that of patients with polyps or cancer. Sixty-one proteins differed significantly between mucosa from healthy subjects and all other tissue types, and 206 differed significantly between healthy mucosa and polyp mucosa. Several of the proteins showing significant underexpression in tumor tissue were cytokeratins and other cytoskeletal components. In contrast, cytokeratins, including several isoforms of cytokeratin 8, were overexpressed in apparently normal mucosa from polyp and cancer patients compared with mucosa from healthy subjects. These findings indicate that protein expression in the apparently normal colonic mucosal field is modified in individuals with neoplastic lesions at sites distant from the lesion. Recognition and further characterization of this field effect at the molecular level may provide protein biomarkers of susceptibility to colorectal cancer and facilitate development of hypotheses for the role of diet and other environmental factors in its causation.
Corroborating cutoff frequency measurements with DC gain measurements (1991)

A test for the correct measurement of the cutoff frequency of bipolar transistors is described. The method tests the equality of the low frequency, small signal, current gain measured by a network analyzer, and by DC current measurements. The method is described, and sample data are shown to demonstrate its practical application.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
AppScanner: Automatic Fingerprinting of Smartphone Apps from Encrypted Network Traffic (2016)

Automatic fingerprinting and identification of smartphone apps is becoming a very attractive data gathering technique for adversaries, network administrators, investigators and marketing agencies. In fact, the list of apps installed on a device can be used to identify vulnerable apps for an attacker to exploit, uncover a victim's use of sensitive apps, assist network planning, and aid marketing. However, app fingerprinting is complicated by the vast number of apps available for download, the wide range of devices they may be installed on, and the use of payload encryption protocols such as HTTPS/TLS. In this paper, we present a novel methodology and a framework implementing it, called AppScanner, for the automatic fingerprinting and real-time identification of Android apps from their encrypted network traffic. To build app fingerprints, we run apps automatically on a physical device to collect their network traces. We apply various processing strategies to these network traces before extracting the features that are used to train our supervised learning algorithms. Our fingerprint generation methodology is highly scalable and does not rely on inspecting packet payloads, thus our framework works even when HTTPS/TLS is employed. We built and deployed this lightweight framework and ran a thorough set of experiments to assess its performance. We automatically profiled 110 of the most popular apps in the Google Play Store and were later able to re-identify them with more than 99% accuracy.
Integrated lock–in amplifier for sensor applications (1999)

An integrated lock-in amplifier for sensor applications is demonstrated. The circuit has been fabricated in a 0.7µm n-well CMOS process with analog features. The equivalent input noise is 17 nV/√Hz at 20 KHz, and the low-pass filter cut-off frequency can be varied in the sub-Hz range. The ability of resolving input steps of 100 nV at 20 KHz in the presence of a 32µV interference at only 5 Hz frequency offset is demonstrated.
Combining Protein Cages and Polymers: from Understanding Self-Assembly to Functional Materials (2016)

Protein cages, such as viruses, are well-defined biological nanostructures which are highly symmetrical and monodisperse. They are found in various shapes and sizes and can encapsulate or template non-native materials. Furthermore, the proteins can be chemically or genetically modified giving them new properties. For these reasons, these protein structures have received increasing attention in the field of polymer-protein hybrid materials over the past years, however, advances are still to be made. This Viewpoint highlights the different ways polymers and protein cages or their subunits have been combined to understand self-assembly and create functional materials.