gebhart/patrepeval huggingface dataset:
Imaging gene expression and signal transduction pathway activity (2003)

Molecular imaging is a new field of study that develops the technology to image disease on a cellular or genetic level rather than on a gross anatomical level. The ability to non-invasively monitor different cellular molecular-genetic processes in vivo is the goal of molecular imaging. The pace of progress in this field is encouraging, particularly in the imaging of gene expression. Recent advances in molecular biology have revealed the genetic sequences and genetic mutations that cause diseases including cancer, functional activities of many genes and proteins, as well as the functional properties of various cellular receptors and their ligands. These discoveries improved our understanding of the fundamental mechanisms of various diseases that lead to the burst of novel genetically based therapies. These discoveries are now being extended into radiologic sciences aiming at non-invasive visualization of the molecular-genetic processes involved in various diseases, non-invasive monitoring of responses to therapy on a molecular level, and to assess the effectiveness of gene transfer and expression in novel gene therapy protocols.
ADVISE: Symbolism and External Knowledge for Decoding Advertisements (2017)

In order to convey the most content in their limited space, advertisements embed references to outside knowledge via symbolism. For example, a motorcycle stands for adventure (a positive property the ad wants associated with the product being sold), and a gun stands for danger (a negative property to dissuade viewers from undesirable behaviors). We show how to use symbolic references to better understand the meaning of an ad. We further show how anchoring ad understanding in general-purpose object recognition and image captioning improves results. We formulate the ad understanding task as matching the ad image to human-generated statements that describe the action that the ad prompts, and the rationale it provides for taking this action. Our proposed method outperforms the state of the art on this task, and on an alternative formulation of question-answering on ads. We show additional applications of our learned representations for matching ads to slogans, and clustering ads according to their topic, without extra training.
Effects of anodal vs. cathodal pacing on the mechanical performance of the isolated rabbit heart (2000)

Previous studies have suggested that anodal pacing enhances electrical conduction in the heart near the pacing site. It was hypothesized that enhanced conduction by anodal pacing would also enhance ventricular pressure in the heart. Left ventricular pressure measurements were made in isolated, Langendorff-perfused rabbit hearts by means of a Millar pressure transducer with the use of a balloon catheter fixed in the left ventricle. The pressure wave was analyzed for maximum pressure (Pmax) generated in the left ventricle and the work done by the left ventricle (Parea). Eight hearts were paced with monophasic square-wave pulses of varying amplitudes (2, 4, 6, and 8 V) with 100 pulses of each waveform delivered to the epicardium. Anodal stimulation pulses showed statistically significant improvement in mechanical response at 2, 4, and 8 V. Relative to unipolar cathodal pacing, unipolar anodal pacing improved Pmax by 4.4 +/- 2.3 (SD), 5.3 +/- 3.1, 3.5 +/- 4.9, and 4.8 +/- 1.9% at 2, 4, 6, and 8 V, respectively. Unipolar anodal stimulation also improved Parea by 9.0 +/- 3.0, 12.0 +/- 6.0, 10.1 +/- 7.7, and 11.9 +/- 6.0% at 2, 4, 6, and 8 V, respectively. Improvements in Pmax and Parea indicate that an anodally paced heart has a stronger mechanical response than does a cathodally paced heart. Anodal pacing might be useful as a novel therapeutic technology to treat mechanically impaired or failed hearts.
Effects of Lowering Average or Below-Average Cholesterol Levels on the Progression of Carotid Atherosclerosis (1998)

Treatment with pravastatin reduced the development of carotid atherosclerosis among patients with coronary heart disease and a wide range of pretreatment cholesterol levels. Treatment with this agent prevented any detectable increase in carotid wall thickening over 4 years of follow-up.
A soft-input soft-output APP module for iterative decoding of concatenated codes (1997)

Concatenated coding schemes consist of the combination of two or more simple constituent encoders and interleavers. The parallel concatenation known as "turbo code" has been shown to yield remarkable coding gains close to theoretical limits, yet admitting a relatively simple iterative decoding technique. The recently proposed serial concatenation of interleaved codes may offer superior performance to that of turbo codes. In both coding schemes, the core of the iterative decoding structure is a soft-input soft-output (SISO) a posteriori probability (APP) module. In this letter, we describe the SISO APP module that updates the APP's corresponding to the input and the output bits, of a code, and show how to embed it into an iterative decoder for a new hybrid concatenation of three codes, to fully exploit the benefits of the proposed SISO APP module.
Efficient bandwidth regulation at memory controller for mixed criticality applications (2016)

We design a bandwidth regulation module, by adapting and extending the algorithm of MemGuard Linux kernel module for hardware implementation. Our extensions differentiate among NoC sources with rate-constrained and best-effort traffic provisions, support a violation free-guaranteed operating mode for rate-constrained flows, and support dynamic adaptivity through EWMA prediction. Our strategies enhance support for mixed criticality applications on MPSoCs. C++-based statistical simulation shows improvements over hardware adaptation of the original MemGuard algorithm without our extensions. Using SystemC, we further evaluate MemGuard at the memory controller of a NoC-based SoC model using an MPEG4 traffic model and compare its hardware cost using synthesis from Xilinx Vivado HLS and Vivado, with ARM AMBA AXI4 and a 4×4 STNoC instance.
Stateful SIP Protocol with Enhanced Security for Proactive Response on SIP Attack (2010)

SIP 프로토콜 기반 VoIP 서비스는 편리함과 저렴한 통신비용으로 사용자 수가 급증하고 있다. 하지만 SIP 프로토콜은 텍스트 형태의 SIP 헤더 정보를 UDP 방식으로 전송하기 때문에 손쉽게 위변조 할 수 있으며, 송신자에 대한 인증 기능을 제공하고 있지 않기 때문에 악의적 공격자에 의해 SIP 패킷 폭주 공격등에 매우 취약하다. 따라서 본 논문에서는 이러한 SIP 취약성을 해결하기 위해 SIP 상태코드를 모니터링 하여 SIP 폭주 공격을 탐지하고 SIP 패킷에 대해 인증 및 보안 기능이 강화된 프로토콜을 제시하였다. SIP 공격탐지 시스템을 구축하여 SIP 세션을 능동적으로 관리하였으며 보안 기능을 강화하기 위해 사용자 인증을 적용하여 SIP 프로토콜의 취약점을 해결할 수 있었다. 본 논문에서 제시한 기법은 기존 SIP 프로토콜에서의 보안 취약성을 해결하고 최소한의 트래픽 전송 지연만으로도 안전하게 패킷을 송수신할 수 있도록 하였으며 SIP 프록시 서버에서의 서비스 지연, 서버의 과부하 등의 문제를 최소화할 수 있도록 설계되었다. The user valence of VoIP services with SIP protocol is increasing rapidly because of cheap communication cost and its conveniency. But attacker can easily modify the packet contents of SIP protocol as SIP header is transmitted by using UDP methods in text form. The reason is that SIP protocols does not provide an authentication function on the transmission session. Therefore, existing SIP protocol is very weak on SIP Packet Flooding attack etc. In order to solve like this kinds of SIP vulnerabilities, we used SIP status codes under the monitoring module for detecting SIP Flooding attacks and additionally proposed an advanced protocol where the authentication and security function is strengthened about SIP packet. We managed SIP session spontaneously in order to strengthen security with SIP authentication function and to solve the vulnerability of SIP protocol. The proposed mechanism can securely send SIP packet to solves the security vulnerability with minimum traffic transmission. Also service delay in SIP proxy servers will be minimized to solve the overload problem on SIP proxy server.
Separation and recovery of critical metal ions using ionic liquids (2016)

Separation and purification of critical metal ions such as rare-earth elements (REEs), scandium and niobium from their minerals is difficult and often determines if extraction is economically and environmentally feasible. Solvent extraction is a commonly used metal-ion separation process, usually favored because of its simplicity, speed and wide scope, which is why it is often employed for separating trace metals from their minerals. However, the types of solvents widely used for the recovery of metal ions have adverse environmental impact. Alternatives to solvent extraction have been explored and advances in separation technologies have shown commercial establishment of liquid membranes as an alternative to conventional solvent extraction for the recovery of metals and other valuable materials. Liquid membrane transport incorporates solvent extraction and membrane separation in one continuously operating system. Both methods conventionally use solvents that are harmful to the environment, however, the introduction of ionic liquids (ILs) over the last decade is set to minimize the environmental impact of both solvent extraction and liquid membrane separation processes. ILs are a family of organic molten salts with low or negligible vapour pressure which may be formed below 100 °C. Such liquids are also highly thermally stable and less toxic. Their ionic structure makes them thermodynamically favorable solvents for the extraction of metallic ions. The main aim of this article is to review the current achievements in the separation of REE, scandium, niobium and vanadium from their minerals, using ILs in either solvent extraction or liquid membrane processes. The mechanism of separation using ILs is discussed and the engineering constraints to their application are identified.
Cerebellar control of a line following robot (1999)

This paper proposes a robot control architecture inspired by the biology of the cerebellum. The cerebellum is thought to be the location of movement coordination in the body. It is hypothesized that through the use of some form of learned internal model, the cerebellum is able to overcome inherent sensory latency and coordinate fast, accurate movement without the need of a complex mathematical algorithm. The study presented in this paper attempts to encapsulate these attributes.in an introductory experiment based around a line following robot. The robot learns to negotiate a circuit using a crude supervising module as the teacher, and
Adaptation of intestinal production of apolipoprotein A-IV during chronic feeding of lipid (2001)

We examined the effect of daily fat supplementation on intestinal gene expression and protein synthesis and plasma levels of apolipoprotein A-IV (apo A-IV). Rats were fasted overnight and then given intragastric bolus infusion of either saline or fat emulsion after 0, 1, 2, 4, 8, or 16 days of similar daily feedings. Four hours after the final saline or fat infusion, plasma and jejunal mucosa were harvested; plasma levels of apo A-IV, triglycerides, and leptin were measured, as well as mucosal apo A-IV mRNA levels and biosynthesis of apo A-IV protein. In response to fat, plasma apo A-IV showed an initial 40% increase compared with saline-injected control rats; with continued daily fat feeding, the plasma A-IV response showed rapid and progressive diminution such that by 4 days, plasma A-IV was not different between fat- and saline-fed groups. Jejunal mucosal apo A-IV synthesis and mRNA levels also showed time-dependent refractoriness to fat feeding. However, the kinetics of this effect were considerably slower than in the case of plasma, requiring 16 days for completion. There was no correlation between plasma leptin or triglyceride levels and intestinal apo A-IV synthesis or plasma apo A-IV. These results indicate rapid, fat-induced, posttranslational adapation of plasma apo A-IV levels and a slower, but similarly complete pretranslational adaptation of intestinal apo A-IV production, which are independent of plasma levels of leptin.
Alteration in the Force and Fatigability of Skeletal Muscle in Quadriplegic Humans Following Exercise Induced by Chronic Electrical Stimulation (1976)

The paralyzed forearm finger flexor muscles of 10 quadriplegic subjects were exercised via electrical stimulation to determine changes in the contractile force and fatigability of the muscle that could be externally induced. The force of contraction initially produced by most muscles was less than that required for functional activity. Following exercise, the strength of all muscles was increased above the level for functional use. In general, no correlation was noted between the amount of exercise and the force change. Two subjects had high contraction forces after prolonged periods before stimulation began, and 4 subjects who were followed after the stimulation program maintained near the contractile force achieved at the end of the program in the absence of stimulation. Fatigue of the muscle during the course of the exercise program was increased to above that recorded initially, although this was more variable and sometimes dropped to less than that recorded initially. Generally, no correlation was demonstrated between usage and fatigue. It is concluded that exercise induced by electrical stimulation alters the cantractile properties of the muscle toward a state usable for functional, tonic activation.
A spectral displacement study of the binding constants of cyclodextrin–hydrocarbon and –fluorocarbon surfactant inclusion complexes (1997)

The spectral displacement technique with phenolphthalein as the chromophore has been used to obtain 1:1 equilibrium binding constants (K 2 ) for a homologous series of hydrocarbon (hc) (C n H 2n+1 COONa, n = 5–13) and fluorocarbon (fc) anionic surfactants (C n F 2n+1 COONa, n = 3–8) with β-cyclodextrin (β-CD). The magnitude of K 2 increases as the alkyl chain length increases in each homologous series. K 2 values in the ranges of 10 2 –10 5 M −1 and 10 1 –10 4 M −1 were obtained for the β-CD–fc and for the β-CD–hc surfactant complexes, respectively. The different binding affinity of β-CD with hc and fc surfactants is discussed in terms of such physicochemical properties of the guest species as hydrophobicity, geometrical size, conformational effects, molecular polarizability, and solvation of the head group. Keywords: spectral displacement, phenolphthalein, cyclodextrin, surfactant, binding constant.
HHMM Based Recognition of Human Activity Motion Trajectories in Image Sequences. (2005)

Reverse flow through the valve is not necessary for the closure of the venous valve. The closure of the venous valve coincides with the decrease of the flow velocities and the ballooning of the sinus (increase of size and the curvature of the valve sinus).
Interleukin-8 Release during Early Reperfusion Predicts Graft Function in Human Lung Transplantation (2002)

Cytokines have been shown to play an important role in promoting inflammation in the setting of ischemia-reperfusion injury. However, their role in human lung transplantation has not been systematically explored. This study was undertaken to examine the kinetics of cytokine release in 18 consecutive human lung transplantation procedures and to examine the relationships between their levels and donor factors, length of ischemic time, and allograft function. TNF-alpha, IFN-gamma, IL-10, IL-12, and IL-18 were found at higher levels during the ischemic time, whereas IL-8 predominantly increased after reperfusion. IL-8 levels after 2 h of reperfusion correlated with lung function assessed by the Pa(O2 )/FI(O(2)) ratio, the mean airway pressure, and the APACHE score during the first 24 postoperative hours. The length of ICU stay also correlated with IL-8 levels after 2 h of reperfusion. Longer ischemic time was associated with significantly higher levels of IL-18 before reperfusion, and older donors had significantly lower levels of IL-10 after reperfusion. We have demonstrated the importance of IL-8 in predicting early graft function after human lung transplantation. In addition, we showed that donor age and ischemic time may influence release of specific cytokines during ischemia-reperfusion.
Development of Data Translators for Interfacing Power-Flow Programs With EMTP-Type Programs: Challenges and Lessons Learned (2013)

This paper describes the challenges and lessons learned when developing industrial-grade data translators aimed for the interfacing of power-flow programs with Electromagnetic Transients Program-type programs. It has been found that the greatest challenges to overcome include: the lack, in the databases used in power-flow programs, of vital pieces of information necessary to perform transient studies; inconsistency in the format of data files; the presence of data entry mistakes in very large databases; the validation of the translated data; and the analysis of the large amount of data that transient simulations provide. Several examples are presented to show the implemented solutions. Finally, recommendations based on experience are made to help future developers of interfacing tools.
Properties of oscillatory neuronal activity in the basal ganglia and thalamus in patients with Parkinson’s disease (2018)

The alterations in neuronal activity in basal ganglia play a critical role in generation of parkinsonism. β oscillatory activity is more prominent in basal ganglia than in thalamus suggesting that the activity likely results from dopaminergic depletion. While both basal ganglia and thalamus have tremor activity, the thalamus appears to play a more important role in tremor production, and basal ganglia β oscillatory activity might be the trigger.
Novel Azolylalkyloxy Compounds with Antipicornaviral Activity (1995)

A novel series of azolylalkyloxy compounds was designed, synthesized and evaluated for antipicornaviral activity. Several of the compounds exhibited in vitro activity comparable to that of Disoxarll. An investigation of qualitative structure-activity relationships indicated that the optimal length of the alkyI chain is six or seven carbon atoms, with seven being marginally superior. The effect of different azole moieties on activity was relatively small, with 3-methylisoxazole and 4-methylthiazole being most effective. The nature of the oxy substituent was found to be extremely important for antipicornaviral activity. The 2-dibenzofuryl group proved to be the most effective oxy substituent for this class of compounds. Compounds 11 and 22, combining dibenzofuran with 3-methylisoxazole and 4-methylthiazole, respectively, were highly effective in vitro against a wide range of human rhinoviruses as well as several enteroviruses.
Cerebral venous blood oxygenation monitoring during hyperventilation in healthy volunteers with a novel optoacoustic system (2013)

Monitoring of cerebral venous oxygenation is useful to facilitate management of patients with severe or moderate traumatic brain injury (TBI). Prompt recognition of low cerebral venous oxygenation is a key to avoiding secondary brain injury associated with brain hypoxia. In specialized clinical research centers, jugular venous bulb catheters have been used for cerebral venous oxygenation monitoring and have demonstrated that oxygen saturation &lt; 50% (normal range is 55–75%) correlates with poor clinical outcome. We developed an optoacoustic technique for noninvasive monitoring of cerebral venous oxygenation. Recently, we designed and built a novel, medical grade optoacoustic system operating in the near-infrared spectral range for continuous, real-time oxygenation monitoring in the superior sagittal sinus (SSS), a large central cerebral vein. In this work, we designed and built a novel SSS optoacoustic probe and developed a new algorithm for SSS oxygenation measurement. The SSS signals were measured in healthy volunteers during voluntary hyperventilation, which induced changes in SSS oxygenation. Simultaneously, we measured exhaled carbon dioxide concentration (EtCO<sub>2</sub>) using capnography. Good temporal correlation between decreases in optoacoustically measured SSS oxygenation and decreases in EtCO<sub>2</sub> was obtained. Decreases in EtCO2 from normal values (35-45 mmHg) to 20-25 mmHg resulted in SSS oxygenation decreases by 3-10%. Intersubject variability of the responses may relate to nonspecific brain activation associated with voluntary hyperventilation. The obtained data demonstrate the capability of the optoacoustic system to detect in real time minor changes in the SSS blood oxygenation.
<title>Improved integrated sniper location system</title> (1999)

In July of 1995, Lockheed Martin IR Imaging Systems, of Lexington, Massachusetts began the development of an integrated sniper location system for the Defense Advanced Research Projects Agency and for the Department of the Navy's Naval Command Control &amp; Ocean Surveillance Center, RDTE Division in San Diego, California. The I-SLS integrates acoustic and uncooled infrared sensing technologies to provide an affordable and highly effective sniper detection and location capability. This system, its performance and results from field tests at Camp Pendleton, California, in October 1996 were described in a paper presented at the November 1996 SPIE Photonics East Symposium<SUP>1</SUP> on Enabling Technologies for Law Enforcement and Security. The I-SLS combines an acoustic warning system with an uncooled infrared warning system. The acoustic warning system has been developed by SenTech, Inc., of Lexington, Massachusetts. This acoustic warning system provides sniper detection and coarse location information based upon the muzzle blast of the sniper's weapon and/or upon the shock wave produced by the sniper's bullet, if the bullet is supersonic. The uncooled infrared warning system provides sniper detection and fine location information based upon the weapon's muzzle flash. In addition, the uncooled infrared warning system can provide thermal imagery that can be used to accurately locate and identify the sniper. Combining these two technologies improves detection probability, reduces false alarm rate and increases utility. In the two years since the last report of the integrated sniper location system, improvements have been made and a second field demonstration was planned. In this paper, we describe the integrated sniper location system modifications in preparation for the new field demonstration. In addition, fundamental improvements in the uncooled infrared sensor technology continue to be made. These improvements include higher sensitivity (lower minimum resolvable temperature), higher spatial resolution, and smaller size. This paper will describe the implementation and status of these improvements.
Whole-brain 3D mapping of human neural transplant innervation (2017)

While transplantation represents a key tool for assessing in vivo functionality of neural stem cells and their suitability for neural repair, little is known about the integration of grafted neurons into the host brain circuitry. Rabies virus-based retrograde tracing has developed into a powerful approach for visualizing synaptically connected neurons. Here, we combine this technique with light sheet fluorescence microscopy (LSFM) to visualize transplanted cells and connected host neurons in whole-mouse brain preparations. Combined with co-registration of high-precision three-dimensional magnetic resonance imaging (3D MRI) reference data sets, this approach enables precise anatomical allocation of the host input neurons. Our data show that the same neural donor cell population grafted into different brain regions receives highly orthotopic input. These findings indicate that transplant connectivity is largely dictated by the circuitry of the target region and depict rabies-based transsynaptic tracing and LSFM as efficient tools for comprehensive assessment of host-donor cell innervation.