gebhart/patrepeval huggingface dataset:
Critical-current measurements in epitaxial films ofYBa2Cu3O7−xcompound (1987)

We have grown epitaxial films of the ${\mathrm{YBa}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{7\mathrm{\ensuremath{-}}\mathrm{x}}$ compound on ${\mathrm{SrTiO}}_{3}$ substrates. The superconducting critical current in these films at 77 K is in excess of ${10}^{5}$ A/${\mathrm{cm}}^{2}$ and at 4.2 K in excess of ${10}^{6}$ A/${\mathrm{cm}}^{2}$.
Unravelling the Role of Fe–Mn Binary Active Sites Electrocatalyst for Efficient Oxygen Reduction Reaction and Rechargeable Zn-Air Batteries (2020)

Transition-metal atoms and/or heteroatom-doped carbon nanostructures is a crucial alternative to find a nonprecious metal catalyst for electrocatalytic oxygen reduction reaction (ORR). Herein, for the first time, we demonstrated the formation of binary (Fe-Mn) active sites in hierarchically porous nanostructure composed of Fe, Mn, and N-doped fish gill derived carbon (Fe,Mn,N-FGC). The Fe,Mn,N-FGC catalyst shows remarkable ORR performance with onset potential (<i>E</i><sub>onset</sub>) of 1.03 V and half-wave potential (<i>E</i><sub>1/2</sub>) of 0.89 V, slightly better than commercial Pt/C (<i>E</i><sub>onset</sub> = 1.01 V, <i>E</i><sub>1/2</sub> = 0.88 V) in alkaline medium (pH > 13), which is attributed to the synergistic effect of Fe-Mn dual metal center as evidenced from X-ray absorption spectroscopic study. We proposed that the presence of Fe-Mn binary sites is actually beneficial for the O<sub>2</sub> binding and boosting the ORR by weakening the O═O bonds. The homemade rechargeable Zn-air battery performance reveals the open-circuit voltage of 1.41 V and a large power density of 220 mW cm<sup>-2</sup> at 260 mA cm<sup>-2</sup> current density outperforming Pt/C (1.40 V, 158 mW cm<sup>-2</sup>) with almost stable charge-discharge voltage plateaus at high current density. The present strategy enriches a route to synthesize low-cost bioinspired electrocatalyst that is comparable to/better than any nonprecious-metal catalysts as well as commercial Pt/C.
Heterogeneous Assay (2016)

Biomolecular screening is now a crucial component of the drug discovery process, and this glossary will be of use to practitioners in the field of screening and to those who interact with the screening community. The glossary contains definitions related to various aspects of the screening process such as assay types, data handling, and relevant technologies. Many of the terms used in this discipline are not covered by existing glossaries, and where they are, the definitions are often not appropriate for this field. Where appropriate, this document provides new or modified definitions to better reflect the new context. The field of biomolecular screening is multidisciplinary in nature, and this glossary, containing authoritative definitions, will be useful not only for regular practitioners, but also for those who make use of data generated during the screening process.
The M694V mutation in Armenian‐Americans: a 10‐year retrospective study of MEFV mutation testing for familial Mediterranean fever at UCLA (2012)

Familial Mediterranean fever (FMF), inherited in an autosomal recessive manner, is a systemic auto-inflammatory disorder characterized by recurrent attacks of fever with peritonitis, pleuritis, synovitis and erysipeloid rash. The marenostrin-encoding fever (MEFV) gene, located on chromosome 16p13.3, is the only gene in which mutations are currently known to cause FMF. To correlate specific genotypes with adverse phenotypes of affected populations residing in the Western United States, a retrospective case series review was conducted of all MEFV gene mutation testing completed at UCLA Clinical Molecular Diagnostic Laboratory between February 2002 and February 2012, followed by clinical chart review of all subjects who either have a single or double mutation. All 12 common mutations in the MEFV gene were analyzed and the M694V variant was found to be associated with an adverse FMF clinical outcome in the Armenian-American population, manifested by earlier onset of disease, increased severity of disease, and renal amyloidosis.
Giant enhancement and facile tuning of photoluminescence in a soft anisotropic magneto-gel (2018)

A soft photoluminescent composite, prepared using a nematic liquid crystal and a fluorescent gelator, exhibits a nearly two orders of magnitude increase in fluorescence on addition of superparamagnetic nanoparticles. The internal magnetic field generated leading to an increase in the population of singlet excitons which affects the radiative efficiency, and enhanced ordering of the LC environment are proposed to be responsible for the large increase seen in fluorescence. Also, the nematic nature of the host liquid crystal medium aids in switching of the fluorescence intensity between its anisotropic limits on application of an external electric field with the switch-off time being faster compared to the field-driven switch-on time.
Nouvelles approches thérapeutiques anti-inflammatoires et antiparasitaires dans les trypanosomoses (2007)

La trypanosomose humaine africaine (THA) et les trypanosomoses animales sont causees par l'inoculation vectorielle de trypanosomes. Différentes espèces de glossines sont vectrices des deux trypanosomes pathogènes pour l'Homme, Trypanosoma brucei gambiense en Afrique de l'Ouest et du Centre, et Trypanosoma brucei rhodesiense en Afrique de l'Est. Au point de piqure, se développe un chancre d'inoculation, puis le parasite envahit le sang et le tissu lymphatique (stade I), enfin, le franchissement de la barrière hémato-méningée définit la phase neurologique de l'affection (stade II). En raison du caractère fatal de l'évolution, le traitement est indispensable, bien que non dénué de toxicité. La suramine et la pentamidine, médicaments du stade I sont plus ou moins bien tolérés, et responsables de réactions médicamenteuses diverses. Le traitement de la phase II fait appel a un dérivé de l'arsenic, l'Arsobal®, qui est responsable, dans 5 a 10% des cas, d'encéphalopathies arsenicales mortelles. De plus, dans les trypanosomoses, de profondes modifications du système immunitaire sont observées. Une hypergammaglobulinemie, de nombreux auto-anticorps, et un syndrome inflammatoire intense sont observes tout au long de la maladie. Ce syndrome inflammatoire, lie a une production exagérée et persistante de cytokines pro-inflammatoires comme le TNF-[alpha], est également responsable d'une partie de la symptomatologie. En effet, il existe une corrélation entre la sévérité de la maladie et le taux de TNF-[alpha] circulant. Par ailleurs, dans les trypanosomoses animales, le role des radicaux libres a également été mis en évidence. C'est dire l'importance de la découverte de nouvelles approches thérapeutiques et cibles moléculaires dans les trypanosomoses. Les polyphenols végétaux possèdent de nombreuses propriétés, en particulier anti-infectieuses et anti-inflammatoires. Parmi les molécules testées, le quercetol s'est révélé très intéressant car il agit sur les deux versants de la pathologie, d'une part en possédant une activité trypanocide et, d'autre part, en inhibant la réponse inflammatoire induite par le parasite. Des études in vitro (cocultures parasites-cellules humaines) ont montre que l'activité trypanocide du quercetol s'exerce a des doses non toxiques pour les cellules humaines. Celle-ci est perçue pour des doses 300 fois plus élevées. L'étude de l'effet trypanocide du quercetol a révélé un nouveau mécanisme de destruction du parasite, l'apoptose, pouvant être visualisée par cryométrie de flux. Le quercetol et des molécules de structure voisine représentent donc une nouvelle approche thérapeutique très intéressante car peu toxique, peu onéreuse, et disponible dans les pays où sévissent les trypanosomoses. Différents polyphenols sont en cours d'étude, pour trouver une molécule active, susceptible de franchir la barrière hémato-méningée, et utilisable en phase neurologique de la THA. (Texte intégral)
An Antioxidant and Anti-ER Stress Combo Therapy Decreases Inflammation, Secondary Brain Damage and Promotes Neurological Recovery following Traumatic Brain Injury in Mice (2022)

The complex pathophysiology of post-traumatic brain damage might need a polypharmacological strategy with a combination of drugs that target multiple, synergistic mechanisms. We currently tested a combination of apocynin (curtails formation of reactive oxygen species), tert-butylhydroquinone (promotes disposal of reactive oxygen species), and salubrinal (prevents endoplasmic reticulum stress) following a moderate traumatic brain injury (TBI) induced by controlled cortical impact in adult mice. Adult mice of both sexes treated with the above tri-combo showed alleviated motor and cognitive deficits, attenuated secondary lesion volume, and decreased oxidative DNA damage. Concomitantly, tri-combo treatment regulated post-TBI inflammatory response by decreasing the infiltration of T cells and neutrophils and activation of microglia in both sexes. Interestingly, sexual dimorphism was seen in the case of TBI-induced microgliosis and infiltration of macrophages in the tri-combo-treated mice. Moreover, the tri-combo treatment prevented TBI-induced white matter volume loss in both sexes. The beneficial effects of tri-combo treatment were long-lasting and were also seen in aged mice. Thus, the present study supports the tri-combo treatment to curtail oxidative stress and endoplasmic reticulum stress concomitantly as a therapeutic strategy to improve TBI outcomes.<b>SIGNIFICANCE STATEMENT</b> Of the several mechanisms that contribute to TBI pathophysiology, oxidative stress, endoplasmic reticulum stress, and inflammation play a major role. The present study shows the therapeutic potential of a combination of apocynin, tert-butylhydroquinone, and salubrinal to prevent oxidative stress and endoplasmic reticulum stress and the interrelated inflammatory response in mice subjected to TBI. The beneficial effects of the tri-combo include alleviation of TBI-induced motor and cognitive deficits and lesion volume. The neuroprotective effects of the tri-combo are also linked to its ability to prevent TBI-induced white matter damage. Importantly, neuroprotection by the tri-combo treatment was observed to be not dependent on sex or age. Our data demonstrate that a polypharmacological strategy is efficacious after TBI.
The Erythrocyte, a Novel Disease-Mediator for COVID-19 Vasculopathy? (2022)

[Figure: see text]
Rotation of polarized light emission from monolayer WS2 induced by high magnetic fields (2017)

Summary form only given. Monolayers of the transition metal dichalcogenides (TMDCs) MoS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , MoSe <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , WS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , WSe <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and MoTe <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> are a new class of atomically thin, direct band gap semiconductors with extraordinary optical and electronic properties. Due to their unique electronic structure the spin and valley (K <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> or K <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> ) of the excitons are locked, which allows for selective, optical addressing of the valleys. These properties render atomically thin TMDCs promising materials for applications in the field of “valleytronics”, where the valley index is used as a carrier for quantum information.We investigate the effect of "valley coherence" in a WS2 monolayer, which results in a linear polarization of the photoluminescence from the A exciton after linearly polarized excitation. An out-of-plane magnetic field causes a splitting of the K+ and Kvalleys of up to 8 meV, called "valley Zeeman splitting" (Fig 1(a)). Interestingly, this leads to a rotation of the emission polarization with respect to the excitation and reduces the polarization degree (Fig 1(b)-(e)). Both effects are explained with a model based on two non-interacting coherent two-level systems. From this, we deduce that the coherent light emission from the valleys decays with a time constant of τc = 260 fs.
Comparative Study of Transversal-Flux Permanent-Magnetic Linear Oscillatory Machines for Compressor (2017)

Traditional moving-magnet transversal-flux linear oscillatory machines (MTLOM) suffer from high fabrication difficulty and cost, low robustness and reliability, and low material utilization ratio, etc. In this paper, a novel stator-magnet moving-iron transversal-flux linear machine (SMTLOM) is proposed, with magnets inserted into the stator yoke (rather than mounted on stator poles) and mover composed of iron core only. First, the topology of proposed SMTLOM is described, as well as its operation principle. Then, the comparison rules are built to make fair comparison between the conventional MTLOM and the novel SMTLOM, from the perspective of practical application, including the same maximum size limitation, output thrust, and thermal source. By using a three-dimensional finite-element analysis (3-D FEA), comparisons of some key performance indexes, such as back electromotive force, thrust per coil length, thrust per magnets volume, thrust per machine volume, temperature distribution, material cost and structure reliability, etc., are made between these two types of machines. The results from 3-D FEA demonstrate that the novel SMTLOM has enjoyed merits of lower fabrication cost and weight, much higher reliability, thrust density, material utilization ratio, etc., which indicate that the novel SMTLOM is more suitable for driving compressor and easier for mass production.
Bell Pepper Texture Measurement and Degradation During Cold Storage (1987)

ABSTRACT GREEN bell peppers stored at 5.6 C and 95% rela-tive humidity were graded for texture over a period of 35 days. The specific texture investigated was a pepper's ability to resist an applied force. Pepper storage time, pepper height and weight correlated well with the compression force and slope of the force-deformation curve of a nondestructive test. Two destructive tests that measured texture at a point on the inside flesh and outside skin of the pepper correlated with time but were found to be imprecise. Peppers found unacceptable by consumers because of insufficient texture were evaluated for texture to determine an acceptance threshold which would indicate the end of shelf life. An exponential model was fitted to the collected data and found to predict texture within approximately 5% over the storage time. The maximum storage life of bell peppers at the above conditions using the exponential model was estimated to be 51 days..
A Haptic Interface with Motor/Brake System for Colonoscopy Simulation (2008)

Training for colonoscopy, which is the examination and treatment of the colon, is often performed on real patients once the physician has passed the novice level. This increases the risk of colon injury to the patient and lengthens the procedure time. Since a decade ago, there has been research on virtual reality surgery simulators with haptic feedback. The main goal is to provide an alternative to traditional training methods on animals, cadavers or real patients. Haptic feedback is a key feature for every surgery simulator for the training of hand-eye coordination. In this paper, a compact and portable haptic interface is presented for the colonoscopy. The haptic interface provides position data acquisition and force feedback in linear and rotational directions with combined electrical motors and passive brakes to cover a large range of forces. The motorized drives are used for active force feedback and friction compensation and the brakes are used for high force rendering without slipping. This novel design allows decoupled motion in both directions.
Fundamentals of Protein Separations: 50 Years of Nanotechnology, and Growing (2008)

The separation of proteins in biology samples has long been recognized as an important and daunting endeavor that continues to have enormous impact on human health. Today's technology for protein separations has its origins in the early nanotechnology of the 1950s and 1960s, and the methods include immunoassays and other affinity extractions, electrophoresis, and chromatography. What is different today is the need to resolve and identify many low-abundance proteins within complex biological matrices. Multidimensional separations are the rule, high speed is needed, and the separations must be able to work with mass spectrometry for protein identification. Hybrid approaches that combine disparate separation tools (including recognition, electrophoresis, and chromatography) take advantage of the fact that no single class of separation can resolve the proteins in a biological matrix. Protein separations represent a developing area technologically, and understanding the principles of protein separations from a molecular and nanoscale viewpoint will enable today's researchers to invent tomorrow's technology.
Sampling system for mass spectrometry of high boiling mixtures using gas chromatography-mass spectrometry (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSampling system for mass spectrometry of high boiling mixtures using gas chromatography-mass spectrometryJoseph E. Schiller and Curtis L. KnudsonCite this: Anal. Chem. 1976, 48, 2, 453–454Publication Date (Print):February 1, 1976Publication History Published online1 May 2002Published inissue 1 February 1976https://pubs.acs.org/doi/10.1021/ac60366a005https://doi.org/10.1021/ac60366a005research-articleACS PublicationsRequest reuse permissionsArticle Views22Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fatigue as an Extra-Intestinal Manifestation of Celiac Disease: A Systematic Review (2018)

Celiac disease may present with a range of different symptoms, including abdominal problems in a broader sense, iron deficiency and "constant tiredness". All of these symptoms should consequently lead the clinicians to consider celiac disease as a potential etiopathogenetic cause. Although the pathophysiology of celiac disease is well documented, the actual mechanisms for disease presentation(s) are less well understood. We here address the topic of fatigue in celiac disease. A systematic literature search identified 298 papers of which five met the criteria for full evaluation. None of the reviewed papers were of high quality and had several methodological weaknesses. We conclude that there is an unmet need to study the contributing factors and management of fatigue in celiac disease.
Genotype-Dependent Tumor Regression in Marek’s Disease Mediated at the Level of Tumor Immunity (2009)

Marek's disease (MD) of chickens is a unique natural model of Hodgkin's and Non Hodgkin's lymphomas in which the neoplastically-transformed cells over-express CD30 (CD30(hi)) antigen. All chicken genotypes can be infected with MD virus and develop microscopic lymphomas. From 21 days post infection (dpi) microscopic lymphomas regress in resistant chickens but, in contrast, they progress to gross lymphomas in susceptible chickens. Here we test our hypothesis that in resistant chickens at 21 dpi the tissue microenvironment is pro T-helper (Th)-1 and compatible with cytotoxic T lymphocyte (CTL) immunity but in susceptible lines it is pro Th-2 or pro T-regulatory (T-reg) and antagonistic to CTL immunity. We used the B2, non-MHC-associated, MD resistance/susceptibility system (line [L]6(1)/line [L]7(2)) and quantified the levels of key mRNAs that can be used to define Th-1 (IL-2, IL-12, IL-18, IFNgamma), Th-2 (IL-4, IL-10) and T-reg (TGFbeta, GPR-83, CTLA-4, SMAD-7) lymphocyte phenotypes. We measured gene expression in both whole tissues (represents tissue microenvironment and tumor microenvironment) and in the lymphoma lesions (tumor microenvironment) themselves. Gene ontology-based modeling of our results shows that the dominant phenotype in whole tissue as well as in microscopic lymphoma lesions, is pro T-reg in both L6(1) and L7(2) but a minor pro Th-1 and anti Th-2 tissue microenvironment exists in L6(1) whereas there is an anti Th-1 and pro Th-2 tissue microenvironment in L7(2). The tumor microenvironment per se is pro T-reg, anti Th-1 and pro Th-2 in both L6(1) and L7(2). Together our data suggests that the neoplastic transformation is essentially the same in both L6(1) and L7(2) and that resistance/susceptibility is mediated at the level of tumor immunity in the tissues.
UFT plus cisplatin combination chemotherapy in the treatment of patients with advanced nonsmall cell lung carcinoma (2000)

Oral UFT plus cisplatin is a moderately active regimen with an extremely low rate of incidence of myelosuppression as an adverse event, and warrants comparison with other cisplatin-based regimens in a prospective randomized trial.
Adult‐onset obesity induced by early life overnutrition could be reversed by caloric restriction (2013)

Overnutrition during the suckling period (small litter, SL) results in the development of adult‐onset obesity. The aim of the study was to investigate if caloric restriction (CR) in the postweaning period can reverse this phenomenon. The control litter (CL) had 12 pups/dam and SL had 3 male pups/dam from the postnatal day 3 until 21. In the postweaning period rats consumed lab chow as indicated: (i) CL and SL groups were on ad libitum regimen up to day 140, (ii) SL/CR group received 24% reduction in daily food intake compared to SL, and (iii) SL/CR/AL group was on 24% CR up to day 94 and then switched over to ad libitum feeding. CR caused reduction in body weight gains and normalized serum glucose, insulin, and leptin levels in SL/CR and SL/CR/AL rats compared to CL. The expression of neuropeptide Y (Npy) and leptin receptor (Lepr) returned to control levels in the hypothalami from SL/CR and SL/CR/AL rats compared to CL. No differences in the expression of pro‐opiomelanocortin and insulin receptor (Insr) were observed among these groups. Altered methylation of specific CpG dinucleotides in the proximal promoter region was observed for the Npy and Insr among these groups. CR resulted in normalized metabolic phenotype and gene expression involved in controlling food intake. The results show that the CR can be a successful intervention for reversing obese phenotype induced by lactational overfeeding. Grant Funding Source : NIH DK61518