gebhart/patrepeval huggingface dataset:
Supplementary Tables 1-2, Appendix materials, Figures 1-2 from <i>In vitro</i> and <i>In vivo</i> Activity of Novel Small-Molecule Inhibitors Targeting the Pleckstrin Homology Domain of Protein Kinase B/AKT (2023)

Supplementary Tables 1-2, Appendix materials, Figures 1-2 from &lt;i&gt;In vitro&lt;/i&gt; and &lt;i&gt;In vivo&lt;/i&gt; Activity of Novel Small-Molecule Inhibitors Targeting the Pleckstrin Homology Domain of Protein Kinase B/AKT
Short‐Time Tuning of the Biological Activity of Functionalized Polyelectrolyte Multilayers (2005)

Abstract This article demonstrates the tuning of the biological activity of a surface functionalized by a polyelectrolyte multilayer. The interaction of protein A with macrophages is used as the model system. The film consists of two polypeptides, poly(lysine) and poly(glutamic acid); each “build‐up” solution is a mixture of the respective D ‐ and L ‐enantiomers ( d and l enantiomers). Cells are deposited on top of the film, and they produce tumor necrosis factor alpha (TNF‐α) as they come into contact with the protein. Depending upon the d/l ‐enantiomer ratio of the polyelectrolyte solutions used for the film build‐up, and the embedding depth of the protein, the production of TNF‐α commences after a varying induction time and displays a transition from no‐production to full‐production, which takes place over a period of time that depends on the film's composition and embedding depth. Thus, it is shown that by changing these two parameters the timing of the protein's activity can be accurately tuned.
Data from Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis (2023)

&lt;div&gt;Abstract&lt;p&gt;The innate immunoregulator STING stimulates cytokine production in response to the presence of cytosolic DNA, which can arise following DNA damage. Extrinsic STING signaling is also needed for antigen-presenting cells to stimulate antitumor T-cell immunity. Here, we show that STING signaling is recurrently suppressed in melanoma cells, where this event may enable immune escape after DNA damage. Mechanistically, STING signaling was suppressed most frequently by epigenetic silencing of either STING or the cyclic GMP-AMP synthase, which generates STING-activating cyclic dinucleotides after binding cytosolic DNA species. Loss of STING function rendered melanoma cells unable to produce type I IFN and other immune cytokines after exposure to cytosolic DNA species. Consequently, such cells were highly susceptible to infection with DNA viruses including HSV1, a variant of which is being developed presently as a therapeutic oncolytic virus [talimogene laherparepvec (T-VEC)]. Our findings provide insight into the basis for susceptibility to viral oncolysis by agents such as HSV1. &lt;i&gt;Cancer Res; 76(22); 6747–59. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Sıcaklığa Duyarlı PNIPAM Hidrojellerde Çapraz Bağlayıcı ve Başlatıcı Sisteminin Karşılaştırılması (2019)

Thermoresponsive hydrogels are three-dimensional polymer networks which undergo conformational changes in aqueous media depending on the external temperature. As the lower critical temperature (LCST) is close to the body temperature, poly(N-isopropylacrylamide) (PNIPAM) is the main thermoresponsive hydrogel used for biomedical applications. Below LCST, PNIPAM hydrogels swell in aqueous media, above LCST they become insoluble and shrink. This behavior makes it possible to design drug release systems controlled by external temperature. Swelling/shrinking response of PNIPAM hydrogel depends on several factors such as crosslinker type, crosslinking density, hydrophobic/hydrophilic balance and initiator type. In this study, the effects of the initiation system and the crosslinker type on different thermoresponsive hydrogels were compared. For this purpose, thermoresponsive hydrogels were synthesized by using ethylene glycol dimethylacrylate (EGDMA) and N,N′-ethylene bisacrylamide (EBAM) as crosslinkers via photo and thermal initiation systems. The hydrogels were characterized by FTIR spectroscopy and scanning electron microscope (SEM). Effects of the initiation system and the crosslinker type on the release, swelling behavior, morphology and the biocompatibility behavior of the hydrogels were investigated. The hydrogels synthesized with EBAM demonstrated more promising results compared to the one synthesized EGDMA. It was concluded that poly(EBAM-co-NIPAM)-P has the highest swelling ratio and poly(EBAM-co-NIPAM)-T is the most biocompatible hydrogel. In terms of release characteristics, there was not a significant difference between the hydrogels, even though their swelling characteristics differ.
ChemInform Abstract: RELATION BETWEEN TRACER DIFFUSION AND ION EXCHANGE IN SILICATE GLASSES (1973)

Abstract Proben eines Na 2 O ′ 3 SiO 2 ‐Glases wurden in einer RbNO 3 ‐Schmelze und umgekehrt Proben eines Rb 2 O ‐ 3 SiO 2 ‐Glases in einer NaNO 3 ‐Schmelze belassen und danach die Rb/Na‐Interdiffusionsprofile im Glas mit Hilfe der Elektronenmikrosonde ermittelt.
Energy Storage for Power Grids and Electric Transportation: A Technology Assessment (2012)

This report attempts to summarize the current state of knowledge regarding energy storage technologies for both electric power grid and electric vehicle applications. It is intended to serve as a reference for policymakers interested in understanding the range of technologies and applications associated with energy storage, comparing them, when possible, in a structured way to highlight key characteristics relevant to widespread use. While the emphasis is on technology, this report also addresses the significant policy, market, and other non-technical factors that may impede storage adoption. It considers eight major categories of storage technology: pumped hydro, compressed air, batteries, capacitors, superconducting magnetic energy storage, flywheels, thermal storage, and hydrogen.
Gas-Phase Ion/Ion Reactions Involving Tris-Phenanthroline Alkaline Earth Metal Complexes as Charge Inversion Reagents for the Identification of Fatty Acids (2018)

Fatty acids (FA) play vital biological roles as energy sources, signaling molecules and key building blocks of complex lipids in cell membranes. Modifications to FA structure and composition are associated with the onset and progression of a number of chronic diseases. Consequently, the sensitive detection and unambiguous structure elucidation of FA is integral to the advancement of biomedical sciences. Recent advances in FA analysis have taken advantage of wet chemical derivatization to enhance detection and drive unique fragmentation in tandem mass spectrometry protocols. Here, we significantly further this approach through demonstrating gas-phase charge inversion of singly deprotonated FA ions, [M - H]<sup>-</sup>, using doubly charged tris-phenanthroline alkaline earth metal complexes, [Cat(Phen)<sub>3</sub>]<sup>2+</sup> (Cat = Mg<sup>2+</sup>, Ca<sup>2+</sup>, Sr<sup>2+</sup>, or Ba<sup>2+</sup>). Metal cationized FA, [M - H + Cat]<sup>+</sup> are obtained after the gas-phase ion/ion reaction. Low-energy collision-induced dissociation (CID) of the [M - H + Cat]<sup>+</sup> cations facilitates double bond localization for a variety of monounsaturated and polyunsaturated FAs. Ultimately, detailed characterization presented unambiguous distinction among FA double bond positional isomers, such as n-3 and n-6 isomers. The method was successfully used to identify the FA profile of corn oil, including double bond localization for unsaturated FAs present.
High-resolution Brillouin light scattering and angle-dependent 9.4-GHz ferromagnetic resonance in MBE-grown Fe/Cr/Fe on GaAs (1997)

Exploiting the high sensitivity of a recently assembled Brillouin-light-scattering (BLS) spectrometer, we investigate the magnetic excitations with nonvanishing in-plane wave vector k in antiferromagnetically coupled Fe/Cr/Fe (001), grown by molecular-beam epitaxy. The BLS spectra reveal surprisingly rich structures not previously observed in this very sample. In addition, we use angle-dependent 9.4-GHz ferromagnetic resonance to probe the uniform (k=0) collective excitation, previously investigated at 35 GHz. The observation of the acoustic and optical modes by both techniques allowed the determination of an accurate set of material parameters from the fit of theoretical curves to all data. While the results do not invalidate earlier conclusions, we offer an updated model which provides an alternative explanation for the observed spectra without the assumption of an extra effective surface anisotropy field.
Simplicial Cone Shrinking Algorithm for Unmixing Nonnegative Sources (2012)

We consider a geometrical approach for solving the Nonnegative Blind Source Separation (N-BSS) problem in the case of noiseless linear instantaneous mixture model. When the sources are nonnegative, the scatter plot of the mixed data is contained in the simplicial cone generated by the mixing matrix. The proposed method, called Simplicial Cone Shrinking Algorithm for Unmixing Nonnegative Sources (SCSA-UNS), estimates the mixing matrix and the sources by finding the Minimum Volume (MV) simplicial cone containing all the mixed data. Simulations on synthetic data shows the efficiency of the proposed method.
Incremental restart (database management) (2002)

A page-based incremental restart algorithm is proposed that enables resuming transaction processing immediately after recovering from a crash. Data items are recovered individually and according to the demands of the post-crash transactions. The support that such an algorithm needs in terms of nonvolatile RAM and efficient log retrieval methods is outlined. It is discussed how to construct high-level recovery based on operation logging on top of the page-based algorithm proposed. It is argued that the unique ways stable memory is used and the structure that is imposed on the log are steps in the right direction in the anticipated evolution of recovery management.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
CellFinder: a cell data repository (2013)

CellFinder (http://www.cellfinder.org) is a comprehensive one-stop resource for molecular data characterizing mammalian cells in different tissues and in different development stages. It is built from carefully selected data sets stemming from other curated databases and the biomedical literature. To date, CellFinder describes 3394 cell types and 50 951 cell lines. The database currently contains 3055 microscopic and anatomical images, 205 whole-genome expression profiles of 194 cell/tissue types from RNA-seq and microarrays and 553 905 protein expressions for 535 cells/tissues. Text mining of a corpus of >2000 publications followed by manual curation confirmed expression information on ∼900 proteins and genes. CellFinder's data model is capable to seamlessly represent entities from single cells to the organ level, to incorporate mappings between homologous entities in different species and to describe processes of cell development and differentiation. Its ontological backbone currently consists of 204 741 ontology terms incorporated from 10 different ontologies unified under the novel CELDA ontology. CellFinder's web portal allows searching, browsing and comparing the stored data, interactive construction of developmental trees and navigating the partonomic hierarchy of cells and tissues through a unique body browser designed for life scientists and clinicians.
After The Cheat (2022)

ABSTRACT A discernible identity of the Japanese American film audience coalesced at a pivotal moment in the history of Japanese immigrants in the United States. That audience formed amidst a discrete event in early American cinema, the release of Cecil B. DeMille’s The Cheat in December 1915. The social construction of that audience emerged as a result of both the historical forces and the public discourses at work: 1) the social circumstances, particularly on the West Coast of the United States, involving intensifying racist thinking; and 2) the discursive event that was negotiated publicly as a controversial response to The Cheat in Japanese American publications. The production of a Japanese American film audience was inevitable by the mid-1910s, and The Cheat was the nodal point. Still, the public controversy over The Cheat in the important Japanese American newspaper Rafu Shimpo made the formation of such a filmgoing identity complicit and transparent.
Internet Banking: Risk Analysis and Applicability o f Biometric Technology for Authentication (2010)

Today's world is one with increasing online access to services. One part of this which is growing rapidly is Internet Banking. This is very convenient and the ready access to the Internet in all first world countries , coupled with the cost Savings from closing bank branches , is driving the operation and adoption of these services. Internet banking allows customers to conduct financial transactions on a se cure website operated by their retail or virtual bank, credit union or building society. Thi s paper mainly focused on providing banking services to customers using web with highly secured technology. Implementing technology is the responsibility of management. We are highlighting the points towards the use of biometric technology in internet banking sys tem for risk management of banks regular activities through authentication.
A Versatile Design of a Controlled Swirl Distortion Generator for Testing Gas Turbine Engines (2008)

Inlet swirl distortion has recently become a major area of concern in the gas turbine engine community. Gas turbine engines are being installed in embedded installations that are downstream of increasingly complicated inlet systems, such as those used in Unmanned Aerial Vehicles (UAVs). These inlet systems can produce complex swirl patterns in addition to total pressure distortion. The effect of swirl distortion on engine or compressor performance and operability must be evaluated. The gas turbine community is developing methodologies to measure and characterize swirl distortion. There is a strong need to develop a mechanism for generating prescribed swirl distortion intensities and patterns for testing compression system sensitivity to swirl distortion. Several devices such as delta wings or complex turning vanes have been proposed and used to generate swirl distortion with limited success. This paper presents a versatile swirl distortion generator design that produces a wide range of swirl distortion patterns of a prescribed strength, including bulk swirl, 1/rev, and 2/rev patterns. It also creates different paired swirl patterns, varying from equal and opposite “twin swirls” to offset swirl pairs. This paper describes the design of the swirl generator. Computational Fluid Dynamics (CFD) results are presented along with some test data which illustrate how the swirl generator functions and how altering the swirl generator configuration can produce different swirl distortion patterns.
Simple, fast method of detection apoptosis in lymphoid cells. (1998)

To facilitate the analysis of apoptotic cells, the present study proposes a new quantitative method based on the changes of light scatter properties of lymphoid cells undergoing apoptosis measured with a hematology analyzer. Peripheral blood lymphocytes from 40 chronic B-lymphocytic leukemia samples, five acute T-lymphoblastic leukemia samples, three healthy donors and from T-cell lines Jurkat, SUB-T1 and SUP T8) were cultured during 72 hours in medium alone or in the presence of chlorambucil, fludarabine or theophylline, all compounds known to be apoptosis inducers, with or without adjunction of interleukin 4. Samples were run on a Bayer-H1 system and the percentage of apoptotic cells was evaluated by monitoring the lobularity index corresponding to the polymorphonuclear population. Results compared to the dUTP-fluorescein method by flow cytometry and dUTP-peroxidase labeling on slides (TUNEL) showed an excellent correlation (chi-square test: P < 0.01). This method is reliable and simple and allows one to measure routinely the percentage of apoptotic lymphoid cells at short notice in a laboratory of hematology. This is especially valuable, particularly in testing the predictive value of in vitro drug-induced apoptosis before starting a chemotherapy protocol.
TRANSPLANTATION OF CULTIVATED CORNEAL EPITHELIAL CELLS ON AMNIOTIC MEMBRANE; PRELIMINARY CLINICAL OUTCOMES. (2000)

Third International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance: Maui, Hawaii; November 15-18, 2000: Abstracts
The HEMOPUMP cardiac assist system: nursing care of the patient (1991)

This article uses a case study to demonstrate the support provided by the HEMOPUMP temporary cardiac assist system. The Nursing Plan of Care addresses the actual and potential problems encountered by the critical care nurse.
Long-term experience in the treatment of α1-antitrypsin deficiency: 25 years of augmentation therapy (2015)

Although it is often under-recognised, α1-antitrypsin deficiency (AATD) represents one of the most common genetic respiratory disorders worldwide. Since the publication of studies in the late 1980s, which demonstrated that plasma-derived augmentation therapy with intravenous α1-antitrypsin (AAT) can reverse the biochemical deficiencies in serum and lung fluid that characterise emphysema, augmentation therapy has become the cornerstone of patient management. This article, with a focus on experience gained in clinical practice in Germany, provides an overview of some of the research highlights and clinical experience gained in the use of augmentation therapy for AATD during the past 25 years, and briefly discusses the potential role of AAT augmentation therapy in lung transplant recipients. Additionally, the goals of AAT augmentation therapy will be discussed, namely to delay the progression of emphysema, reduce the frequency of exacerbations and improve health-related quality of life. Beyond pulmonary disease, there is recent growing evidence to indicate that AATD could also play a role in rare disorders such as panniculitis, granulomatosis with polyangiitis and ulcerative colitis.
ChemInform Abstract: First Examples of Six‐Coordinate Homoleptic Complexes with Monodentate Arenethiolate Ligands. Synthesis and Structural Characterization of ( Ph4P)2(Nb(SPh)6), Na(THF)3Nb(SPh‐pMe)6, ((15‐crown‐5)Na)(Ta(SPh)6), and Nb2(μ2‐SPh)4(SPh)2Cl2(C2H5CN)2. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Further observations on tissue heating patterns using an invasive ground probe with radiofrequency hyperthermia system. (1984)

Critical modifications have been made in the grounded elements of a previously reported hybrid radiofrequency heating system with inductive, capacitive, and grounded elements designed for deep focal heating. These modifications facilitate introduction of the ground probe, the single invasive element of the system, into animals and humans. The modified grounded elements also enable monitoring and optimization of ground point current, thereby improving control of heating rate, and greatly increase the volume of tissue that can be heated using a single invasive grounding element, embedded in a lossy dielectric field in the near field of the radiofrequency hyperthermia system.
Bottom-Up Activation of the Vocal Motor Forebrain by the Respiratory Brainstem (2008)

Brainstem motor structures send output commands to the periphery and are dynamically modulated by telencephalic inputs. Little is known, however, about ascending brainstem control of forebrain motor structures. Here, we provide the first evidence for bottom-up activation of forebrain motor centers by the respiratory brainstem. We show that, in the avian vocal control system, activation of the brainstem inspiratory nucleus paraambigualus (PAm), a likely homolog of the mammalian rostral ventral respiratory group, can drive neural activity bilaterally in the forebrain vocal control nuclei HVC (used as a proper name) and the robust nucleus of the arcopallium (RA). Furthermore, this activation is abolished by lesions of nucleus uvaeformis (Uva), a thalamic nucleus necessary for song production. We identify a type of bursting neuron within PAm whose activity is correlated, in an Uva dependent manner, to bursting activity in RA, rather than to the respiratory rhythm, and is robustly active during the production of stimulus evoked vocalizations. Because this ascending input results in cross-hemisphere activation, our results suggest a crucial role for the respiratory brainstem in coordinating forebrain motor centers during vocal production.
Efficacy and Safety of an Infectious Bursal Disease Virus Intermediate Vaccine in ovo (2001)

The study was divided into two experiments. In the first experiment, the efficacy of in ovo intermediate vaccine against infectious bursal disease virus (IBDV) was determined by challenge at 21 days of age with virulent IBDV in specific-pathogen-free (SPF) and commercial chickens. This vaccine was able to induce active immunity and to protect SPF chickens to challenge; protection was not complete in commercial chickens, as testified by bursal lesions, bursal index after challenge, and vaccine immunoresponse. In order to detect field and vaccinal viruses, immunoperoxidase staining, enzyme-linked immunosorbent assay, capture, and reverse transcriptase-polymerase chain reaction (RT-PCR) were tested; the RT-PCR was more effective at detecting both kind of viruses. In the second experiment, the immunosuppressive effect of in ovo vaccination was determined by evaluating the immunoresponse against Newcastle disease virus (NDV) vaccination effected at 10 days in both SPF and commercial chickens vaccinated in ovo. The in ovo vaccine causes a reduction of NDV immunoresponse, as testified by lowest geometric mean titer in group I (SPF chickens vaccinated against IBDV in ovo and against NDV at 11 days). In commercial chickens, immunoresponse to NDV vaccination was not influenced by in ovo vaccination.
The Chameleon of Cardiology: Cardiac Sarcoidosis Before and After Heart Transplantation (2019)

Cardiac sarcoidosis is a chronic inflammatory disease with a large spectrum of symptoms that can mimic diseases such as dilated, hypertrophic, or arrhythmogenic cardiomyopathies. It can be asymptomatic but can also present with ventricular arrhythmias, conduction disease, and heart failure (HF) or even sudden cardiac death (SCD). We present here the case of a patient transplanted due to end-stage arrhythmogenic right ventricular cardiomyopathy (ARVC), fulfilling the task force criteria. A few years after successful heart transplantation (HTX), the patient developed similar symptoms and morphofunctional changes of the heart, which led to critical re-evaluation of his primary diagnosis.