gebhart/patrepeval huggingface dataset:
Alterations in Muc2 biosynthesis and secretion during dextran sulfate sodium-induced colitis (2002)

To gain insight into mucin 2 (Muc2) synthesis and secretion during dextran sulfate sodium (DSS)-induced colitis, rats were treated with DSS for 7 days. Colonic segments were excised on days 0 (control), 2 (onset of disease), 7 (active disease), and 14 (regenerative phase) for histological evaluation. Explants were metabolically labeled with (35)S-labeled amino acids or [(35)S]sulfate followed by chase incubation. Homogenates were analyzed by SDS-PAGE and (35)S-labeled Muc2 was quantified. Also, total Muc2 protein and mRNA were quantified. DSS-induced crypt loss, ulcerations, and concomitant goblet cell loss were most pronounced in the distal colon. Muc2 precursor synthesis increased progressively in the proximal colon but was unaltered in the distal colon during onset and active disease. During the regenerative phase, Muc2 precursor synthesis levels normalized in the proximal colon but increased in the distal colon. Total Muc2 levels paralleled the changes seen in Muc2 precursor synthesis levels. During each disease phase, total Muc2 secretion was unaltered in the proximal and distal colon. [(35)S]sulfate incorporation into Muc2 only decreased in the proximal colon during active disease and the regenerative phase, whereas secretion of [(35)S]sulfate-labeled Muc2 increased. During the regenerative phase, Muc2 mRNA levels were downregulated in both colonic segments. In conclusion, DSS-induced loss of goblet cells was accompanied by an increase or maintenance of Muc2 precursor synthesis, total Muc2 levels, and Muc2 secretion. In the proximal colon, Muc2 became undersulfated, whereas sulfated Muc2 was preferentially secreted. Collectively, these data suggest specific adaptations of the mucus layer to maintain the protective capacities during DSS-induced colitis.
A Secure and Robust Connectivity Architecture for Smart Devices and Applications (2010)

Convergence environments and technologies are urgently coming close to our life with various wireless communications and smart devices in order to provide many benefits such as connectivity, usability, mobility, portability, and flexibility as well as lower installation and maintenance costs. Convergence has brought important change not only in the way we live but also in the way we think. It is the progress towards the attempt to create and to evolve new valuable services through the device convergence and fusion of in-home, office, and various environments around the personal mobile apparatus. Based on the dynamic trends of convergence, it is widely argued that the increased requirements on secure and robust connectivity between a variety of mobile devices and their applications provide us the era of real pervasive computing environment. Thus, in this paper, we present a novel connectivity architecture using RF4CE-(Radio Frequency for Consumer Electronics-) based wireless zero-configuration and enhanced key agreement approach. We analyze the security and performance of our proposed approach by the development of the prototype H/W and the construction of a testbed with CE and mobile devices.
Mutation spectrum of FOXC1 and clinical genetic heterogeneity of Axenfeld-Rieger anomaly in India. (2003)

Significant genetic heterogeneity of FOXC1 was observed in a multi-ethnic population studied in this region of India resulting in variable ARA phenotypes. The different visual outcome seen in the patients suggest a variable expression of FOXC1 and also provide some insight for understanding the gene functions in this population.
Complete reconstitution of mouse liver with xenogeneic hepatocytes. (1995)

We have developed a system for studying hepatocellular growth potential in which liver cells are introduced into the diseased livers of albumin-urokinase (Alb-uPA) transgenic mice. To use this system to study xenogeneic cell transplantation, rat liver cells were introduced into immunotolerant Alb-uPA transgenic mice. In regenerated recipient livers, up to 100% of hepatocellular gene expression was of rat origin, demonstrating the creation of a functional mouse liver in which parenchyma is derived from xenogeneic (rat) hepatocytes. Immunotolerant Alb-uPA transgenic mice provide a tool for studying hepatocellular biology of any species, including humans, in a controlled experimental setting.
The mechanism of the marine β‐carboline thromboxane B 2 inhibitor Manzamine A: role of p90 ribosomal S6 kinase 1 (2013)

Manzamine A (MZA) inhibited LPS‐treated rat microglia (BMΦ) TXB 2 (IC 50 &lt;0.016 μM) and O 2 − (IC 50 =0.1 μM) generation, (BMC Pharmacology 5(1) 6, 2005), LPS‐treated human BMΦ TXB 2 (apparent IC 50 &lt;0.7 μM) (Inflam Res. 53(S3): S217, 2004) and rat p90 ribosomal S6 kinase 1 (RSK1) (IC 50 =15.01 μM) (Program 545.5, Society of Neuroscience, 2009). RSK1 is expressed in LPS‐treated rat microglia (BMΦ) ( Faseb Journal 26: 1124.1, 2012). We hypothesized that in BMΦ MZA might inhibit RSK1 phosphorylation induced at residues S380 and T573 by kinases activated by PMA, a PKC activator. In order to test our hypothesis, we determined the presence of constitutive and phosphorylated RSK1 proteins in murine BV‐2 BMΦ cell line. Briefly, we prepared protein extracts from untreated, LPS (100 ng/mL)‐treated, LPS + PMA (1μM)‐treated BV‐2 BMΦ in the presence or absence of DMSO and MZA (3, 10 and 30 μM), and probed by western blot analysis using constitutive RSK1 (Cell Signaling) and phosphorylated RSK1 (pRSK1) antibodies against S380 (Epitomics) and T573 (Cell Signaling). Results 1) Constitutive RSK1 and pRSK1 proteins were present in all BV‐2 BMΦ extracts tested; 2) PMA enhanced pRSK1 protein in LPS‐treated BV‐2 BMΦ; 3) MZA did not inhibit pRSK1 protein on either S380 and T573 in LPS + PMA‐treated BV‐2 BMΦ. Future studies will determine 1) whether RSK1 in primary rat microglia show a similar response to MZA, and 2) evaluate the effect of MZA on phosphorylation of RSK1 at residues S221, S154, T359, S363, S732. Support to KC by the Office of Research, Midwestern University is gratefully acknowledged.
Speech/music discrimination based on posterior probability features (1999)

A hybrid connectionist-HMM speech recognizer uses a neural network acoustic classifier. This network estimates the posterior probability that the acoustic feature vectors at the current time step should be labelled as each of around 50 phone classes. We sought to exploit informal observations of the distinctions in this posterior domain between nonspeech audio and speech segments well-modeled by the network. We describe four statistics that successfully capture these differences, and which can be combined to make a reliable speech/nonspeech categorization that is closely related to the likely performance of the speech recognizer. We test these features on a database of speech/music examples, and our results match the previously-reported classification error, based on a variety of special-purpose features, of 1.4% for 2.5 second segments. We also show that recognizing segments ordered according to their resemblance to clean speech can result in an error rate close to the ideal minimum over all such subsetting strategies.
Extragonadal germ cell tumors.Clinicopathologic findings and treatment experience in 12 patients (1988)

In patients with primary germ cell tumors, treatment with combination chemotherapy followed by surgical debulking of residual tissue usually produces favorable results. The best treatment for patients with extragonadal germ cell tumors (EGCT) remains a problem. In our series of 12 patients, important clinical features were related to the site of bulky tumor, and all patients exhibited sharply elevated levels of lactate dehydrogenase (LDH), beta subunit human chorionic gonadotropin (beta-HCG), and/or alpha-fetoprotein (AFP). Each patient was treated with systemic chemotherapy, and ten were treated with the same combination chemotherapy--cyclophosphamide, actinomycin, vinblastine, bleomycin, and cisplatin (VAB) alternating with VP-16 and vincristine (VV). Of these ten patients, five died of progressive disease, three of whom had brain metastases. The other five are alive and clinically free of disease. The addition of VP-16 and vincristine did not improve responses. Advanced disease at presentation contributes to the poorer prognosis for these patients. Earlier diagnosis and surgical debulking may improve the long-term survival of patients with this disease.
Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function (2022)

Abstract Improving muscle function has great potential to improve the quality of life. To identify novel regulators of skeletal muscle metabolism and function, we performed a proteomic analysis of gastrocnemius muscle from 73 genetically distinct inbred mouse strains, and integrated the data with genomics and &gt;300 molecular/phenotypic traits via quantitative trait loci mapping and correlation network analysis. These data identified thousands of associations between protein abundance and phenotypes and can be accessed online ( https://muscle.coffeeprot.com/ ) to identify regulators of muscle function. We used this resource to prioritize targets for a functional genomic screen in human bioengineered skeletal muscle. This identified several negative regulators of muscle function including UFC1, an E2 ligase for protein UFMylation. We show UFMylation is up-regulated in a mouse model of amyotrophic lateral sclerosis, a disease that involves muscle atrophy. Furthermore, in vivo knockdown of UFMylation increased contraction force, implicating its role as a negative regulator of skeletal muscle function.
Comprehensive Circuit Model of Autolimiting Superconductor Devices (2016)

This paper presents a phenomenological equivalent circuit to model the phenomenon occurring when a section of superconducting transmission line transits from a superconducting state to a normal state. This phenomenon allows the use of superconductors for the design of autolimiting structures based on superconducting transmission line sections. Although this autolimiting effect happens when the current density achieved in the superconductor exceeds the critical current inherent to the superconducting material, heating effects also play a significant role in this behavior. The equivalent circuit presented in this work accounts for both electric and thermal effects, and the interaction between them. The circuit model is then used for the evaluation of a practical microwave and frequency selective IMUX configuration.
Analysis by reverse-phase high-pressure liquid chromatography of phenylisothiocyanate-derivatized 1-aminocyclopropane-1-carboxylic acid in apple extracts (1986)

A rapid and sensitive method for the determination of 1-aminocyclopropane-1-carboxylic acid (ACC) in apple tissues is described. This method is based on the derivatization of ACC with phenylisothiocyanate, and the subsequent separation and quantification of the resulting phenylthiocarbamyl-ACC by reverse-phase high-pressure liquid chromatography. Phenylthiocarbamylation of ACC (and other amino acids) in apple extracts is complete within 20 min at room temperature. After removing solvents and reagent, the phenylthiocarbamyl derivatives are separated on an octadecyl reverse-phase column, eluted with a mixture of acetonitrile and sodium acetate buffer at pH 4.6, and monitored with a uv detector set at 254 nm. An analysis of apple extract can thus be achieved in 23 min and detect quantities as low as 1 pmol. Assays have been done to compare the efficiency of this method with that of a method using an ion-exchange amino acid analyzer and with that of Lizada and Yang's method [(1979), Anal. Biochem. 100, 140-145]. The latter method proved to yield markedly less accurate results than the other two, but the derivatization-HPLC method was preferred because of simplicity of operation and a better separation of ACC.
Undergraduate dental students’ perceptions of an internship at a Brazilian family health strategy center (2022)

We conducted a cross-sectional study to evaluate the perceptions of undergraduate dental students (UDSs) of an internship in primary dental care within a Family Health Strategy Team (FHS-T) and associated factors. Data were collected via a self-report questionnaire. Poisson regression models were used in multivariate analysis (p&lt;0.05). Of 175 UDSs included, 150 (85.7%) classified the FHS-T internship as important to their dental education. Being enrolled in the Community Dental Health (CDH) III course (vs CDH I) increased by 9% (prevalence ratio [PR] 1.09; 95% confidence interval [CI], 0.99-1.21) the likelihood of students classifying the internship as important to their dental education. Considering the start of the FHS-T internship in the 7th semester adequate (vs inadequate) increased this likelihood by 15% (PR 1.15; 95% CI, 1.05-1.25). Classifying user embracement and home visits as important (vs unimportant) activities also increased this likelihood by 8% (PR 1.08; 95% CI, 0.99-1.17) and 21% (PR 1.21; 95% CI, 1.09-1.33), respectively. Our results suggest that the early insertion of UDSs in the FHS-T and their involvement in ‘user embracement’ and ‘home visits’ activities can significantly contribute to delivering interprofessional dental education.
Using precomputation in architecture and logic resynthesis (1998)

Article Free Access Share on Using precomputation in architecture and logic resynthesis Authors: Soha Hassoun Tufts University, Medford, MA Tufts University, Medford, MAView Profile , Carl Ebeling University of Washington, Seattle, WA University of Washington, Seattle, WAView Profile Authors Info & Claims ICCAD '98: Proceedings of the 1998 IEEE/ACM international conference on Computer-aided designNovember 1998 Pages 316–323https://doi.org/10.1145/288548.288632Published:01 November 1998Publication History 5citation186DownloadsMetricsTotal Citations5Total Downloads186Last 12 Months12Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Characteristics of polyimide liquid crystal alignment films for active matrix-lcd use. (1995)

Synthesis, characterization, and liquid crystal (LC) aligning capability of polyimide (PI) for the active matrix (AM) liquid crystal display (LCD) application are demonstrated and discussed. The synthesized PI materials in this research are featured by: 1) a low curing temperature below 200 C due to their organic-solvent-soluble property; 2) a good unidirectional LC alignment; 3) a useful capability for generating desired pretilt angles; and 4) an excellent voltage holding ratio. The methods and mechanisms of the unidirectional LC alignment, the generation of pretilt angle, and voltage holding ratio are discussed.
On the dynamic formation of cooperative multipoint transmissions in small cell networks (2012)

The ever-growing data rate requirements of next-generation mobile networks mandate a highly efficient exploitation of the spectral and energy resources. In this respect, a key technology which can allow high quality-of-service provisioning with reasonable energy expenditures is given by the deployment of Coordinated Multi-point (CoMP) transmissions for small cells. While the benefits of CoMP have been explored in the literature, little has been done to study how a network can adaptively decide on whether or not to adopt CoMP. To this end, in this paper, we propose a cooperative framework for small cell networks, in which groups of small cells dynamically decide when to perform CoMP transmission while optimizing the tradeoff between rate improvement and energy consumption. We formulate the problem as a dynamic coalitional game with the small base stations as players, and we provide a distributed algorithm that allows the small cells to self-organize into CoMP-based coalitions. The resulting network partition represents the ϵ-core of the game, which is a key solution concept for dynamic coalition games. Simulation results show that the proposed dynamic coalition formation algorithm leads to a significant gain of up to 41% sum rate to transmit power ratio in the small cell tier.
ChemInform Abstract: Chemical Identification of Binding Sites for Calcium Channel Antagonists (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Applied Multivariate Techniques (1997)

Applied multivariate techniques , Applied multivariate techniques , کتابخانه دیجیتال جندی شاپور اهواز
Transcatheter thrombosis of a leaking saccular aneurysm of the main renal artery with preservation of renal blood flow. (1990)

Percutaneous techniques have been used in the treatment of aneurysms and pseudoaneurysms in a variety of anatomic locations, including the kidney. An elderly patient with a leaking saccular aneurysm of the main left renal artery was considered a poor operative risk. We were able to embolize and thrombose the aneurysm selectively by using a combination of coil springs, guidewire, thrombin, and bucrylate without occluding the renal artery.
Application QoS management for the reverse link of a 3G network (2005)

Third generation (3G) wireless networks have been designed to provide high speed data services on both forward and reverse links. In addition to increased data capacity, they also support QoS (quality of service) for mobile users. Users may run multiple applications (service instances) simultaneously and QoS guarantees must be assured for one or more of them. We address the problem of providing QoS guarantees on the reverse link of a 3G (CDMA) network. We present a flexible, low overhead framework for efficient management of the reverse link resources to satisfy the QoS guarantees of each user's applications. We show how the QoS demands of all service instances of a particular user can be converted and combined into a single resource demand, namely the data rate of the corresponding reverse link channel.
ASTRI SST-2M: the design evolution from the prototype to the array telescope (2018)

The Cherenkov Telescope Array (CTA) observatory will represent the new frontier of imaging atmospheric Cherenkov Telescope. The simultaneous use of large, medium and small telescopes (respectively LST, MST and SST) will allow to explore the astronomy related to the very high energy domain, typical of Gamma rays, with a sensitivity, angular resolution and image quality never seen before. Within this project, ASTRI, the Italian 2 mirrors Schwarzshild-Couder configuration Small SST led by Italian National Institute of Astronomy (INAF), has moved quickly developing a 4m class telescope prototype which has been tested with results which demonstrates excellent performance as well as wide margins for further improvements. On the basis of the experiences made on the prototype, this paper focus on the design enhancements carried out for the telescope which will be part of the Cherenkov Telescope Array.
Symbolic Kinship Program (1997)

This paper discusses a computerized algorithm to derive the formula for the likelihood ratio for a kinship problem with any arbitrarily defined relationships based on genetic evidence. The ordinary paternity case with the familiar likelihood formula 1/2q is the commonest example. More generally, any miscellaneous collection of people can be genetically tested to help settle some argument about how they are related, what one might call a "kinship" case. Examples that geneticists and DNA identification laboratories run into include sibship, incest, twin, inheritance, motherless, and corpse identification cases. The strength of the genetic evidence is always described by a likelihood ratio. The general method is described by which the computer program finds the formulas appropriate to these various situations. The benefits and the interest of the program are discussed using many examples, including analyses that have previously been published, some practical problems, and simple and useful rules for dealing with scenarios in which ancestral or fraternal types substitute for those of the alleged father.
A facile and general synthesis of 2,4‐Di‐ and 2,4,7‐trisubstituted thieno[2,3‐c]pyridines (2008)

Abstract magnified image Treatment of 3,5‐dibromo‐ or 3,5‐dichloro‐pyridine‐4‐carboxaldehyde 2 with one equivalent of methyl thioglycolate, followed by exposure to base, provided 4‐bromo‐ or 4‐chloro‐thieno[2,3‐ c ]pyridine‐2‐carboxylate 4 in good yields. Oxidation of the thieno[2,3‐ c ]pyridine scaffold such as 7 with mCPBA, followed by treatment with POBr 3 , introduced a bromine exclusively at the 7‐position of the heterocycle. The 4‐ or 7‐bromide of the thienopyridines readily underwent Suzuki, Stille coupling, and Buchwald amination reactions, to afford 4‐ or 7‐substituted analogs 6 or 11 . The 2‐carboxylate of 4b or 12 was smoothly removed through saponification and decarboxylation to furnish 15 or 16 . Deprotonation of the thienopyridine at C‐2 position, followed by trapping with trimethyltin chloride, afforded a 2‐stannyl analog, which was readily converted to other C‐2 derivatives via Stille reaction.
Mean field analysis for inhomogeneous bike sharing systems (2012)

In the paper, bike sharing systems with stations having a finite capacity are studied as large stochastic networks. The inhomogeneity is modeled by clusters. We use a mean field limit to derive the limiting stationary distribution of the number of bikes at the stations. This approach is an alternative to analytical methods. It can be used even if a closed form expression for the stationary distribution is out of reach as illustrated on a variant. Both models are compared. A practical conclusion is that avoiding empty or full stations does not improve overall performance.
Efficient program scheduling for heterogeneous multi-core processors (2009)

Heterogeneous multicore processors promise high execution efficiency under diverse workloads, and program scheduling is critical in exploiting this efficiency. This paper presents a novel method to leverage the inherent characteristics of a program for scheduling decisions in heterogeneous multicore processors. The proposed method projects the core's configuration and the program's resource demand to a unified multi-dimensional space, and uses weighted Euclidean distance between these two to guide the program scheduling. The experimental results show that on average, this distance based scheduling heuristic achieves 24.5% reduction in energy delay product, 6.1% reduction in energy, and 9.1% improvement in throughput when compared with traditional hardware oblivious scheduling algorithm.