gebhart/patrepeval huggingface dataset:
Identifying the potential origin of mucin in primary cutaneous mucinoses—A retrospective study and analysis using histopathology and multiplex fluorescence staining (2023)

Various cell types seem to contribute to mucin production in PCM. Using MFS, we showed that CD8+ T cells seem to be more involved in the production of mucin in FM than in dermal mucinoses, which could indicate that mucin in dermal and follicular epithelial mucinoses have different origins.
Supplementary Figure Legends 1-5 from RAP80 Is Critical in Maintaining Genomic Stability and Suppressing Tumor Development (2023)

&lt;p&gt;PDF file - 71K&lt;/p&gt;
Gene expression profiling data in lymphoma and leukemia: review of the literature and extrapolation of pertinent clinical applications. (2006)

Gene expression profiling of lymphomas and leukemias aids in the diagnosis and prognostication of these diseases. The extrapolation of these findings to more timely, efficient, and cost-effective methods, such as flow cytometry and immunohistochemistry, results in better diagnostic tools to manage the diseases. Flow cytometric and immunohistochemical applications of the information gained from GE profiling assist in the management of chronic lymphocytic leukemia, other low-grade B-cell non-Hodgkin lymphomas and leukemias, diffuse large B-cell lymphoma, nodular lymphocyte-predominant Hodgkin lymphoma, and classic Hodgkin lymphoma. For practical clinical use, GE profiling of precursor B acute lymphoblastic leukemia, precursor T acute lymphoblastic leukemia, and acute myeloid leukemia has supported most of the information that has been obtained by cytogenetic and molecular studies (except for the identification of FLT3 mutations for molecular analysis), but extrapolation of the analyses leaves much to be gained based on the GE profiling data.
Synthesis and Characterization of Trivalent Metal Containing Mesoporous Silicas Obtained by a Neutral Templating Route (1996)

A series of trivalent metal cation containing mesoporous silicas have been synthesized using a primary alkylamine, e.g., hexadecylamine as organic templating surfactant. Using this synthesis route, it was possible to prepare materials where trivalent cations were tetrahedrally coordinated, with Si/Me ratios as low as 10 without observing the presence of octahedral species. These materials possessed regular mesopores of about 37 Å diameter and very high surface areas. In contrast to pure silica materials obtained following a similar synthesis route, these solids were not thermally stable, and calcination in air resulted in a partial collapse of the mesopores and in a partial extraction of trivalent cations. However, templating molecules could be easily removed from the mesopores by a solvent extraction. Removal of the template by this way preserved not only the mesopore framework but also the coordination of the cations. Solvent-extracted solids were thermally stable and could be calcined in air at high temperature without observing changes in the nature and coordination of the cations. The present synthesis route seemed thus to be particularly interesting to prepare template-free mesoporous silicas containing relatively high amounts of tetrahedrally coordinated trivalent cations.
Targeting a bacterial DNABII protein with a chimeric peptide immunogen or humanised monoclonal antibody to prevent or treat recalcitrant biofilm-mediated infections (2020)

Supported by R01 DC011818 to LOB and SDG.
Empirical fit to band discontinuities and barrier heights in III–V alloy systems (1992)

We present a figure summarizing the variation of conduction band discontinuity, valence band discontinuity, and gold Schottky barrier height for binary and ternary III–V semiconductors. This figure, which applies to unstrained material, makes use of the property of transitivity in band alignments, and the observed experimental correlation between barrier heights and band gap discontinuities, to consolidate a wide range of data. The figure should be very useful in the design of novel heterostructure electronic and optical devices.
SyncLink: high-speed DRAM for the future (1996)

In 1987 it was becoming apparent that computer systems would need to communicate at data rates beyond the capabilities of then current approaches. To take on this challenge, the IEEE Futurebus group formed a new group dedicated to building a fast, coherent interface, scalable from the smallest computer to the largest mainframe. The IEEE officially established the SCI (Scalable Coherent Interface) working group, referenced as IEEE P1596, in 1988. Today the SCI is IEEE Std 1596. It has several derivatives that enhance its operation and meet additional needs such as real-time operations: a differential voltage specification (IEEE 1536.3), a point-to-point memory interface (IEEE 1596.4), and SyncLink (IEEE P1596.7). SyncLink is a new, high-speed memory interface that combines synchronous dynamic RAM (SDRAM), developed in the late 1980s, and the IEEE's RamLink interface, developed in 1990. SyncLink uses the earlier interface's packet protocol as a base but eliminates its point-to-point link to reduce latency. The new interface uses SDRAM's internal pipelining and control for efficient bus utilization. It allows access in the lowest latency possible for a very high bandwidth DRAM. Future plans include data rates of 800 Mbits per pin per second in 1998, to double in the early 2000s. This rate will allow systems to operate at full capability, even when running 3D graphics.
A CMOS 3.3-8.4 GHz wide tuning range, low phase noise LC VCO (2009)

A novel inductor switching technique is used to design and implement a wideband LC voltage controlled oscillator (VCO) in 0.13 mum CMOS. The VCO has a tuning range of 87.2% between 3.3 and 8.4 GHz with phase noise ranging from -122 to -117.2 dBc/Hz at 1 MHz offset. The power varies between 6.5 and 15.4 mW over the tuning range. This results in a power-frequency-tuning normalized figure of merit (PFTN) between 6.6 and 10.2 dB which is one of the best reported to date.
Expense Control (2016)

We investigate a crowd-based approach to enhance the outcome of optical character recognition in the domain of receipt capturing to keep track of expenses. In contrast to existing work, our approach is capable of extracting single products and provides categorizations for both articles and expenses, through the use of microtasks which are delegated to an unpaid crowd. To evaluate our approach, we developed a smartphone application based on a receipt analysis and an online questionnaire in which users are able to track expenses by taking photos of receipts, and solve microtasks to enhance the recognition. To provide additional motivation to solve these tasks, we make use of gamification. In a three-week-long user study (N=12), we found that our system is appreciated, that our approach reduces the error rate of captured receipts significantly, and that the gamification provided additional motivation to contribute more and thereby enrich the database.
Estimation of added resistance and ship speed loss in a seaway (2017)

The prediction of the added resistance and attainable ship speed under actual weather conditions is essential to evaluate the true ship performance in operating conditions and assess environmental impact. In this study, a reliable methodology is proposed to estimate the ship speed loss of the S175 container ship in specific sea conditions of wind and waves. Firstly, the numerical simulations are performed to predict the added resistance and ship motions in regular head and oblique seas using three different methods; a 2-D and 3-D potential flow method and a Computational Fluid Dynamics (CFD) with an Unsteady Reynolds-Averaged Navier-Stokes (URANS) approach. Simulations of various wave conditions are compared with the available experimental data and these are used in a validation study. Secondly, following the validation study in regular waves, the ship speed loss is estimated using the developed methodology by calculating the resistance in calm water and the added resistance due to wind and irregular waves, taking into account relevant wave parameters and wind speed corresponding to the Beaufort scale, and results are compared with simulation results obtained by other researchers. Finally, the effect of the variation in ship speed and therefore the ship speed loss is investigated. This study shows the capabilities of the 2-D and 3-D potential methods and CFD to calculate the added resistance and ship motions in regular waves in various wave headings. It also demonstrates that the proposed methodology can estimate the impacts on the ship operating speed and the required sea margin in irregular seas.
Polymer Science in Undergraduate Chemical Engineering and Industrial Chemistry Curricula: A Modular Approach (2006)

Polymer science has long been underrepresented in the traditional chemical engineering and (industrial) chemistry curricula, although it is an integral part of the professional practice of most chemistry and chemical engineering graduates. The present contribution details a modular implementation of four polymer science courses of varying difficulty and content tailored for students from engineering as well as chemistry backgrounds. The courses seek to fuse traditional elements of polymer chemistry and physics with emerging cutting-edge technologies at the nexus of organic and polymer chemistry. We demonstrate that a challenging and effective curriculum can be constructed and embedded in a teaching approach composed of interactive lectures and tutorials, engaging laboratory exercises, and literature work incorporating elements of cutting-edge research. The contribution also gives an overview and recommendation of the textbooks suitable for the various courses.
Pharmacological characterization of the norepinephrine and dopamine reuptake inhibitor EB‐1020: Implications for treatment of attention‐deficit hyperactivity disorder (2012)

We report on the pharmacological, behavioral, and neurochemical characterization of a novel dual norepinephrine (NE)/dopamine (DA) transporter inhibitor EB-1020 (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane HCl). EB-1020 preferentially inhibited monoamine reuptake in cloned cell lines transfected with human transporters with IC₅₀ values of 6 and 38, respectively, for NE and DA transporters. In microdialysis studies, EB-1020 markedly increased NE, and DA concentrations levels in rat prefrontal cortex in vivo with peak increases of 375 and 300%, respectively with the greatest effects on NE, and also increased DA extracellular concentrations in the striatum to 400% of baseline concentrations. Behavioral studies demonstrated that EB-1020 dose-dependently decreased immobility in the mouse tail suspension test of depression to 13% of control levels, and did not stimulate locomotor activity in adult rats in the optimal dose range. EB-1020 dose-dependently inhibited locomotor hyperactivity in juvenile rats lesioned with the neurotoxin 6-hydroxydopamine (100 μg intracisternally) as neonates; a well-established animal model for attention-deficit hyperactivity disorder (ADHD). These data suggest that EB-1020 mediates its actions by stimulating NE and DA neurotransmission, which are typically impaired in ADHD.
<title>WWICE: an architecture for in-home digital networks</title> (1999)

The transition to digital information and networking of new digital devices lead to considerable changes in the consumer electronic industry. New applications will arise, offering more entertainment, comfort and flexibility. To achieve this, complex problems in communication and distributed systems need to be solved. High requirements on stability, usability, quality and price call for new solutions. This paper describes the concept of In-Home Digital Networks and will then in detail address the WWICE system. This new architecture provides a coherent system environment for the home. It focuses on services and applications, which can easily be accessed and controlled by the user. Application framework and middleware services of the layered software architecture efficiently support development of IHDN applications as well as flexible application control at runtime.
IMMUNOREACTIONS INVOLVING PLATELETS. VI. REACTIONS OF MATERNAL ISOANTIBODIES RESPONSIBLE FOR NEONATAL PURPURA. DIFFERENTIATION OF A SECOND PLATELET ANTIGEN SYSTEM* (1962)

Although there is some evidence that neonatal thrombocytopenic purpura, which occurs in otherwise normal children born of healthy mothers, is caused by maternal antibodies formed against fetal platelets (1-3), lack of reliable serologic techniques generally has prevented convincing demonstration of the responsible antibodies and has precluded thorough investigation of the properties and inheritance of specific platelet antigens presumed to be involved. Because experience in this laboratory has shown that complement fixation is the most sensitive technique for detecting several different types of antiplatelet antibodies (4-6), this technique was applied in a search for antibodies in the sera of normal mothers who had given birth to thrombocytopenic infants. In the present report the isoantibodies which were found are characterized, and the sensitivity of the complement fixation technique is compared with that of other techniques employed in attempts to detect antiplatelet antibodies.
Poleward Microtubule Flux Is a Major Component of Spindle Dynamics and Anaphase A in Mitotic Drosophila Embryos (2021)

During cell division, eukaryotic cells assemble dynamic microtubule-based spindles to segregate replicated chromosomes [1, 2]. Rapid spindle microtubule turnover, likely derived from dynamic instability, has been documented in yeasts [3, 4], plants [5] and vertebrates [6]. Less studied is concerted spindle microtubule poleward translocation (flux) coupled to depolymerization at spindle poles [7]. Microtubule flux has been observed only in vertebrates [7], although there is indirect evidence for it in insect spermatocytes [8, 9] and higher plants [10]. Here we use fluorescent speckle microscopy (FSM) to demonstrate that mitotic spindles of syncytial Drosophila embryos exhibit poleward microtubule flux, indicating that flux is a widely conserved property of spindles. By simultaneously imaging chromosomes (or kinetochores) and flux, we provide evidence that flux is the dominant mechanism driving chromosome-to-pole movement (anaphase A) in these spindles. At 18°C and 24°C, separated sister chromatids moved poleward at average rates (3.6 and 6.6 μm/min, respectively) slightly greater than the mean rates of poleward flux (3.2 and 5.2 μm/min, respectively). However, at 24°C the rate of kinetochore-to-pole movement varied from slower than to twice the mean rate of flux, suggesting that although flux is the dominant mechanism, kinetochore-associated microtubule depolymerization contributes to anaphase A.
Correction for Assetta et al., “JC Polyomavirus Infection of Primary Human Renal Epithelial Cells Is Controlled by a Type I IFN-Induced Response” (2019)

Volume 7, issue 4, e00903-16, 2016, [https://doi.org/10.1128/mBio.00903-16][1]. RNA-seq data presented in the article have been made publicly available on the NCBI Gene Expression Omnibus site (GEO), accession number [GSE135833][2].

 [1]: /lookup/doi/10.1128/mBio.00903-16
 [2]: https://www.ncbi.nlm
Numerical quantification of damage accumulation resulting from blanking in multi-phase steel (2018)

The high potentials of utilizing high strength steels in the automotive industry have been proved. However, there are still some unsolved challenges. Forming of a component that has been produced by blanking is one of these. Blanking is commonly used in sheet metal forming as the initial cutting process. Yet, it introduces damage into the blanked edges that in subsequent forming steps may lead to crack formation. This problem arises in particular in modern multi-phase steels and can currently not be avoided thoroughly due to a lack of understanding of the relevant influences. In the present work, the effects of the blanking process on an HCT980XD sheet were therefore numerically investigated. To achieve this, the Edge-Fracture-Tensile-Test method was simulated. By using this method, a conventional uniaxial tensile specimen is manufactured with one milled side and one blanked side. This allows to highlight the effect of blanking in a subsequent tensile test. In order to investigate the damage process, the coupled Modified-Bai-Wierzbicki model was applied to simulate first the blanking process and then the tensile test. The results revealed that during the blanking process, the failure initiated from the surface elements near the punch and propagated through the thickness. Meanwhile, another crack initiated from the opposite side of the sheet. The elements of these cracks experienced near pure-shear condition at both damage initiation and fracture moments. At the end of this step, the remaining damage, which is considered as the predamage of the next step, was higher in the middle of thickness. During the subsequent uniaxial tension, the crack in the specimen initiated at a shear cut edge and crossed the width. The possible detailed resolution of loading paths and crack formation shows that the damage mechanics simulation provides researchers with a powerful tool for assessing limit states in forming processes.
Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents (2018)

It is now established that the thieno[2,3-<i>b</i>]pyridines are a potent class of antiproliferatives. One of the main issues encountered for their clinical application is their low water solubility. In order to improve this, two strategies were pursued. First, a morpholine moiety was tethered to the molecular scaffold by substituting the sulphur atom with nitrogen, resulting in a 1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine core structure. The water solubility was increased by three orders of magnitude, from 1.2 µg/mL (<b>1</b>-thieno[2,3-<i>b</i>]pyridine) to 1.3 mg/mL (<b>3</b>-pyrrolo[2,3-<i>b</i>]pyridine), however, it was only marginally active against cancer cells. The second strategy involved loading a very potent thieno[2,3-<i>b</i>]pyridine derivative (<b>2</b>) into a cholesteryl-poly(allylamine) polymer matrix for water solubilisation. Suppression of human pancreatic adenocarcinoma (BxPC-3) viability was observed to an IC<sub>50</sub> value of 0.5 μg/mL (1.30 μM) in conjunction with the polymer, which is a five-fold (×5) increase in potency as compared to the free drug alone, demonstrating the utility of this formulation approach.
Deficit Reduction Through Diversity: How Affirmative Action at the FCC Increased Auction Competition (1996)

In recent auctions for paging licenses, the Federal Communications Commission has granted businesses owned by minorities and women substantial bidding credits. In this article, Professors Ayres and Cramton analyze a particular auction and argue that the affirmative action bidding preferences, by increasing competition among auction participants, increased the government's revenue by $45 million. Subsidizing the participation of new bidders can induce established bidders to bid more aggressively. The authors conclude that this revenue-enhancing effect does not provide a sufficient constitutional justification for affirmative action—but when such justification is independently present, affirmative actions can cost the government much less than is currently thought.
LibGuides: English Language Support: Study Skills for International Students (2015)

An overview of English Language Support available from Library and Learning Services external web links to study skills pages
Les convertases des prohormones et le système nerveux (1993)

Les convertases sont impliquees dans le processus de maturation des neuropeptides formes a partir de precurseurs polypeptidiques. Ces enzymes de clivage agissent de facon specifique par la reconnaisance d'un site constitue, le plus souvent, de deux acides amines basiques (lysine et arginine). Recemment, deux convertases PC1 et PC2 ont ete identifiees. Celles-ci sont exprimees dans les neurones de nombreuses regions des systemes nerveux central et peripherique. Les convertases PC1 et PC2 clivent les produits des genes codant pour la proopiomelanocortine (POMC) et la luteoliberine (LH-RH) respectivement. L'expression qualitative et quantitative d'une grande variete de polypeptides actifs est soumise a la regulation des convertases
Cutting Edge: TLR9 and TLR2 Signaling Together Account for MyD88-Dependent Control of Parasitemia in Trypanosoma cruzi Infection (2006)

Activation of innate immune cells by Trypanosoma cruzi-derived molecules such as GPI anchors and DNA induces proinflammatory cytokine production and host defense mechanisms. In this study, we demonstrate that DNA from T. cruzi stimulates cytokine production by APCs in a TLR9-dependent manner and synergizes with parasite-derived GPI anchor, a TLR2 agonist, in the induction of cytokines by macrophages. Compared with wild-type animals, T. cruzi-infected Tlr9(-/-) mice displayed elevated parasitemia and decreased survival. Strikingly, infected Tlr2(-/-)Tlr9(-/-) mice developed a parasitemia equivalent to animals lacking MyD88, an essential signaling molecule for most TLR, but did not show the acute mortality displayed by MyD88(-/-) animals. The enhanced susceptibility of Tlr9(-/-) and Tlr2(-/-)Tlr9(-/-) mice was associated with decreased in vivo IL-12/IFN-gamma responses. Our results reveal that TLR2 and TLR9 cooperate in the control of parasite replication and that TLR9 has a primary role in the MyD88-dependent induction of IL-12/IFN-gamma synthesis during infection with T. cruzi.
MZI optical isolator with Si-wire waveguides by surface-activated direct bonding (2012)

We fabricate a Mach-Zehnder interferometer-based optical isolator using a silicon-wire waveguide with magneto-optic garnet cladding using direct bonding techniques. Using Si-wire waveguides, the size of the device is greatly reduced from that of our previous device. We investigate surface-activated direct bonding with nitrogen plasma treatment, which shows better bonding results than oxygen plasma treatment. A large magneto-optic phase shift of 0.8π and an optical isolation of 18 dB are obtained at a wavelength of 1322 nm.
Copper‐Catalyzed Transformation of Carbonyl‐ene‐nitrile Compounds: Vinylation, Imino Ene Reaction, and Alkynylation of 2‐Aza‐2,4‐cyclopentadienone Intermediates Generated via Ritte‐Type Hydration and Dehydrative Cyclization Reactions. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A review of the Environmental Impact of Large Dams in Iran (2013)

Water is very important as one of the main factors of human life for drinking as well as purposes related to human life and human nature. Increasing demand of water caused the emerging science of dam engineering and also construction large dams for agricultural purposes, drinking, industry and also flood control, power generation, recreational and tourist use and etc. Large dams can remarkably effect on the environment as a nonstabilizing factor in nature in various stages of construction, operation and end of life by stopping the flow of the river and stored water. However, if the environment cannot tolerate this instability, the results of the destruction of this structure will gradually rise and the objective of dam construction will be lost. The reality is that, the environmental effects are not considered fully and completely for the most dams have been constructed in Iran. In this paper, we will review the environmental impact of construction large dams on some rivers in the country and after that we will investigate some ways to deal with the effects and finally we will separately examine the use of several small dams instead of big dams as an important and effective option. Keywords— Dam, Environment, Large Dams, Sivand Dam, Getvand Dam