gebhart/patrepeval huggingface dataset:
Potential Purine Antagonists. XXXI. The Preparation of Certain 9-Alkyl-2-amino-6-purinethiols and Related Derivatives as Antitumor Agents (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotential Purine Antagonists. XXXI. The Preparation of Certain 9-Alkyl-2-amino-6-purinethiols and Related Derivatives as Antitumor AgentsC. Wayne. Noell and Roland K. RobinsCite this: J. Med. Chem. 1962, 5, 3, 558–588Publication Date (Print):May 1, 1962Publication History Published online1 May 2002Published inissue 1 May 1962https://pubs.acs.org/doi/10.1021/jm01238a016https://doi.org/10.1021/jm01238a016research-articleACS PublicationsRequest reuse permissionsArticle Views157Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Pt-Enhanced Mesoporous Ti3+/TiO2 with Rapid Bulk to Surface Electron Transfer for Photocatalytic Hydrogen Evolution (2016)

Pt-doped mesoporous Ti<sup>3+</sup> self-doped TiO<sub>2</sub> (Pt-Ti<sup>3+</sup>/TiO<sub>2</sub>) is in situ synthesized via an ionothermal route, by treating metallic Ti in an ionic liquid containing LiOAc, HOAc, and a H<sub>2</sub>PtCl<sub>6</sub> aqueous solution under mild ionothermal conditions. Such Ti<sup>3+</sup>-enriched environment, as well as oxygen vacancies, is proven to be effective for allowing the in situ reduction of Pt<sup>4+</sup> ions uniformly located in the framework of the TiO<sub>2</sub> bulk. The photocatalytic H<sub>2</sub> evolution of Pt-Ti<sup>3+</sup>/TiO<sub>2</sub> is significantly higher than that of the photoreduced Pt loaded on the original TiO<sub>2</sub> and commercial P25. Such greatly enhanced activity is due to the various valence states of Pt (Pt<sup>n+</sup>, n = 0, 2, or 3), forming Pt-O bonds embedded in the framework of TiO<sub>2</sub> and ultrafine Pt metal nanoparticles on the surface of TiO<sub>2</sub>. Such Pt<sup>n+</sup>-O bonds could act as the bridges for facilitating the photogenerated electron transfer from the bulk to the surface of TiO<sub>2</sub> with a higher electron carrier density (3.11 × 10<sup>20</sup> cm<sup>-3</sup>), about 2.5 times that (1.25 × 10<sup>20</sup> cm<sup>-3</sup>) of the photoreduced Pt-Ti<sup>3+</sup>/TiO<sub>2</sub> sample. Thus, more photogenerated electrons could reach the Pt metal for reducing protons to H<sub>2</sub>.
Richard Baxter (1615–91) (1990)

Abstract This chapter discusses the significance, the life, and the contributions of Richard Baxter. Baxter was ‘the outstanding figure among ejected ministers’. He is justly famous for his energetic pastoral ministry at Kidderminster from 1641 to 1660. He was equally noted for his distinctive theological and ecclasiastical position, in which he advocated the ‘middle way’ between the extremes of the day. A prophet of ecumenical comprehension, he was less successful in ending the Protestant fragmentation of his day than in his evangelistic and pastoral activities. However, his ‘pacific vision’ has earned him just renown, even if his methods were deficient in realism and common sense.
Printing 3D light field with 1D halftone screening (2012)

Lenticular printing is an old technique, which enables stereoscopic 3D by recording pictures taken by two or more cameras onto one medium. It is often awkward in its transition between insufficient images due to sparse sampling from the light space. In this paper, we propose a method for making 3D print which reproduces light space represented as a light field by introducing an ideal halftone screening.
Presurgical mapping of basal cell carcinoma or squamous cell carcinoma by confocal laser endomicroscopy compared to traditional micrographic surgery: a single-centre prospective feasibility study (2016)

Our results are promising regarding the distinction between tumour and healthy surrounding tissue, and indicate that presurgical mapping of basal cell carcinoma and squamous cell carcinoma is possible. The tool itself should be developed further with special attention to early detection of skin cancer.
Performance of next-generation sequencing on small tumor specimens and/or low tumor content samples using a commercially available platform (2018)

Specimen suitability remains a major obstacle to clinical NGS testing. We determined that PCR-based library creation methods allow the use of smaller specimens, and those with a lower percentage of tumor cells to be run on the PCDx NGS platform.
Genome-wide experimental identification and functional analysis of human specific retroelements (2005)

Retroelements (REs) actively reshape genomes through genomic rearrangements, creation of new genes and modulation of the regulatory machinery of existing genes, thus introducing genomic novelties which potentially may be subject to natural selection. Thousands of RE integrations, presumably distinguishing the human and chimpanzee genomes, might well be involved in modern human speciation. In this self-review we describe our recent results on genome-wide identification of human specific RE integrations and their transcriptional activity obtained with three new experimental techniques (TGDA, DiffIR and SDDIR) developed by us for such studies. A new mechanism of the formation of retroelements involving template switches during L1-mediated mRNA reverse transcription, revealed in this research, will also be described in the review.
Troglitazone suppresses transforming growth factor-β1-induced collagen type I expression in keloid fibroblasts (2008)

Our data suggest that PPAR-gamma is present in keloid fibroblasts and PPAR-gamma activation inhibits TGF-beta1-induced collagen type I expression at least in part by decreasing collagen synthesis. PPAR-gamma may be a promising therapeutic target for keloids.
Synthesis and Investigation of Surface Active Properties of Counterion Coupled Gemini Surfactants (2013)

Abstract Three counterion coupled gemini (cocogem) surfactants in the series 1,6‐bis( N,N ‐alkyldimethylammonium) adipate, referred as n ‐6‐ n ( n = 12, 14, 16), were synthesized, purified and characterized by 1 H NMR and 13 C NMR. Their physicochemical properties were investigated by electrical conductivity and surface tension measurements. The degree of ionization, critical micelle concentration (CMC), surface excess at the air/solution interface (Γ max ), minimum area per surfactant molecule at the air/solution interface ( A min ), surface tension at the CMC ( γ CMC ), and p C 20 (negative log of the surfactant molar concentration, required to reduce the surface tension of water by 20 mN m −1 ) were calculated. Increase in tail length of the surfactants increases the efficiency of surfactants to decrease the surface tension of water. Thermodynamic parameters, viz. molar free energy at the maximum adsorption attained at CMC ( G min ), standard Gibb's energy of micellization ( ), and standard Gibbs energy of adsorption ( ), were also calculated. The and values show that the monomers were preferred to be adsorbed at the air/water interface and then in the micellar formation in the bulk. Additionally, fluorescence measurements were used to find the aggregation number. Other relevant surface properties (Krafft point, emulsion stability, foaming ability, micellar stability and dye solubilization ability) were also evaluated. These results suggest that with respect to emulsion formation, micellar stability and dye solubilization, the cocogem with a 16‐carbon chain gives better results, producing 89 % more stable foams and shows better aggregational behavior.
DEVELOPMENT OF THE FEMALE REPRODUCTIVE TRACT (2007)

The reproductive tract of female mammals derives from the Müllerian duct that forms during embryogenesis. The Müllerian duct gives rise to the oviducts, uterus, cervix, and upper portion of the vagina. We will present studies on the mechanisms of Müllerian duct formation, using molecular, fate-mapping, and experimental embryological studies in transgenic mice. Our studies show that the Mü llerian duct forms predominantly by proliferation of cells located at its caudal tip. We suggest that these cells represent a stem cell pool that resides in a highly specialized niche between the Wolffian duct and the coelomic epithelium. Fate-mapping studies of the Müllerian duct epithelium using a Wnt7a-Cre transgenic mouse line are underway to determine which cell types this tissue gives rise to in the adult female reproductive tract.
Conservative and behavioural management of constipation (2009)

This article deals with psychological contributions, such as stool withholding or responses to abuse experiences, to the aetiology of evacuation disorders (with a focus on dyssynergic defecation), and with education and behavioural approaches to treatment.
Compression of redundancy free trellis stages in turbo‐decoder (2013)

For turbo codes with a coding rate close to one, the high puncturing rate induces long sequences of trellis without a redundancy bit. A simplification technique to compute the final state of a sequence of redundancy free trellis stages (RFTSs) is presented. It compresses a sequence of RFTSs of length N into a sequence of RFTSs of length m − 1 + ( N mod ( m − 1)), where m is the number of states of the trellis. The computation is reduced accordingly.
Studies on the Structure-Activity Relationship of Thiepin and Oxepin Derivatives to Antiinflammatory Activities (1981)

o r y a ct i v i t y was e x a m i n e d b y t h e m e t h o d o f c a r r a g e e n a n edema.
CBRA: Color-based ranking aggregation for person re-identification (2015)

The problem of automatically tracking a pedestrian within camera networks with non-overlapping field-of-view, known as person re-identification, is a challenging task with still suboptimal results. Different features have been proposed in the literature, specially colors which achieved the best results when fused in a unique feature representation. Despite being better than considering individually, the fusion still does not explores all the feature discriminative power. Therefore, we propose the use of rank aggregation to improve the results. In this paper, we address the person re-identification problem using a Color-based Ranking Aggregation (CBRA) method, which explores different feature representations to obtain complementary ranking lists and combine them using the Stuart ranking aggregation method. The obtained experimental results demonstrate a great improvement in state-of-the-art, reaching top-1 rank recognition rates of 50.0% and 56.9% in the ViPER and PRTD450S data sets, respectively.
B12-O-21Development of High Pressure Gas Environmental Cell and its Application to Hydrogen Reaction (2015)

We developed a high pressure gas Environmental cell for High Voltage Electron Microscope (EHVEM) and applied it to in-situ High-Resolution (HR) observation on hydrogen reaction. The sample was a Pd thin film (∼10 nm thickness) deposited on a Silicon Nitride (SiN) window film. Firstly, this film was observed in a vacuum condition at room temperature, and then, an in-situ observation was carried out with the hydrogen pressure up to 40 kPa. The microscope used in this study was the EHVEM based on the JEOL ARM-1300 and operated at an acceleration voltage of 1250 kV. Results of high resolution in-situ observation of Pd in H2 are shown Fig. 1 . Based on IFFT, the number of dislocation cores was increased with increasing the hydrogen pressure. This result indicated that the hydrogen reaction expanded Pd lattice, which caused the dislocation emission, especially at internal boundaries, such as grain boundaries and twin boundaries. It means hydrogen reaction could take place at internal boundaries.
An integrated cognitive computing approach for systematic conceptual design (2016)

Conceptual design plays an important role in product life cycle, which requires engineers to use sound design theory, cross-disciplinary knowledge, and complex technical support to acquire design concepts. However, the lack of sufficient computational tools makes it difficult for designers to fully explore in the wide design solution spaces. Therefore, this paper proposes an integrated cognitive computing approach to formalize the cognitive activities of conceptual design. A cognitive computing model composed of concept associative memory, concept generation, and decision-making process is established based on the integration of cognitive psychology and engineering design. First of all, the Hopfield neural network is used to acquire similar concept solutions for specific subfunctions from a knowledge base. Then, morphological matrix and genetic algorithm are introduced to produce a set of feasible candidate solutions in the concept generation process. Furthermore, a technique for order preference by similarity to an ideal solution is applied to evaluate the generated concept solutions and obtain the optimal solution automatically. Finally, a case study is given to demonstrate the effectiveness and efficiency of the proposed approach.
Sub-Gaussian rotation-invariant features for steerable wavelet-based image retrieval (2005)

This paper presents a new rotation-invariant image retrieval method, which extends a recently introduced classification technique based on steerable wavelet transforms. In the proposed procedure, the feature extraction step consists of estimating the covariations (lower-order cross-correlations) between the wavelet subband coefficients, which are modeled as subGaussian random vectors. The similarity measurement is carried out first by employing norms calculating the distance between the covariation matrices representing two distinct images and second by evaluating the Kullback-Leibler Distance (KLD) between their corresponding subGaussian distributions. We provide analytical expressions relating the subGaussian features corresponding to a rotated image from the features of the original image. Finally, we relate the employed optimal lower-order correlation (p/spl les/2) to the degree of nonGaussianity of the wavelet coefficients, and we demonstrate the effectiveness of our method using real texture images.
Die Substitution mit Alpha1-Antitrypsin ist bei Patienten mit schwerem Alpha1-Antitrypsin-Mangel (Pi*ZZ-Genotyp) mit einer Verbesserung Leber-bezogener Parameter assoziiert (2019)

Die klassische Form des Alpha1-Antitrypsin (AAT)-Mangels (Pi*ZZ-Genotyp) stellt aufgrund der Lungen- und Leberbeteiligung eine der häufigsten letal verlaufenden genetischen Erkrankungen dar. Während die intravenöse Substitution mit AAT die Progression der Pi*ZZ-assoziierten Lungenerkrankung hemmt, stellt die Lebertransplantation die einzige Behandlungsoption der Pi*ZZ-assoziierten Lebererkrankung dar. Da eine AAT-Gabe in vitro zu einer verminderten hepatozytären AAT-Expression führt und da AAT in experimentellen Mausmodellen hepatoprotektiv wirkt, evaluierten wir den Einfluss der AAT-Substitution auf den Leber-Phänotyp bei Pi*ZZ-Patienten.
Text Segmentation as a Supervised Learning Task (2018)

Omri Koshorek, Adir Cohen, Noam Mor, Michael Rotman, Jonathan Berant. Proceedings of the 2018 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Volume 2 (Short Papers). 2018.
A dynamic ensemble learning algorithm for neural networks (2019)

This paper presents a novel dynamic ensemble learning (DEL) algorithm for designing ensemble of neural networks (NNs). DEL algorithm determines the size of ensemble, the number of individual NNs employing a constructive strategy, the number of hidden nodes of individual NNs employing a constructive–pruning strategy, and different training samples for individual NN’s learning. For diversity, negative correlation learning has been introduced and also variation of training samples has been made for individual NNs that provide better learning from the whole training samples. The major benefits of the proposed DEL compared to existing ensemble algorithms are (1) automatic design of ensemble; (2) maintaining accuracy and diversity of NNs at the same time; and (3) minimum number of parameters to be defined by user. DEL algorithm is applied to a set of real-world classification problems such as the cancer, diabetes, heart disease, thyroid, credit card, glass, gene, horse, letter recognition, mushroom, and soybean datasets. It has been confirmed by experimental results that DEL produces dynamic NN ensembles of appropriate architecture and diversity that demonstrate good generalization ability.
Copper in Alzheimer's Disease: A Meta-Analysis of Serum, Plasma, and Cerebrospinal Fluid Studies (2012)

This contribution reviews and corrects data from our previous meta-analysis, which appeared in the Journal of Alzheimer's Disease in 2011 concerning the role of copper in Alzheimer's disease. We repeated the meta-analysis after excluding four of the five studies from our laboratory to avoid possible bias in the result. In addition, we included two studies on serum copper levels in Alzheimer's disease not previously considered. The results indicate higher levels of copper in Alzheimer's disease patients than in controls, confirming our previous conclusion.
Swiss Cohort & Biobank—An Ambitious and Timely Large-Scale Cohort Study (2023)

COMMENTARY Int J Public Health, 17 March 2023 https://doi.org/10.3389/ijph.2023.1605886
Dual metal gate FinFET integration by Ta/Mo diffusion technology for Vt reduction and multi-Vt CMOS application (2008)

Dual metal gate CMOS FinFETs have been integrated successfully by the Ta/Mo interdiffusion technology. For the first time, low-Vt CMOS FinFETs representing on-current enhancement and high-Vt CMOS FinFETs reducing stand-by power dramatically, namely multi-Vt CMOS FinFETs, are demonstrated by selecting Ta/Mo gates for n or pMOS FinFETs with non-doped fin channels. The dual metal gate FinFET SRAM with a low-Vt configuration is demonstrated with excellent noise margins at a reduced supply voltage.
Alterations in genes other than EGFR/ALK/ROS1 in non-small cell lung cancer: trials and treatment options. (2016)

During the last decade, we have seen tremendous progress in the therapy of lung cancer. Discovery of actionable mutations in EGFR and translocations in ALK and ROS1 have identified subsets of patients with excellent tumor response to oral targeted agents with manageable side effects. In this review, we highlight treatment options including corresponding clinical trials for oncogenic alterations affecting the receptor tyrosine kinases MET, FGFR, NTRK, RET, HER2, HER3, and HER4 as well as components of the RAS-RAF-MEK signaling pathway.
On the super lateral growth phenomenon observed in excimer laser-induced crystallization of thin Si films (1994)

This letter reports on the experimental findings, and provides a theoretical description of the super lateral growth (SLG) phenomenon observed in the pulsed laser-induced solidification of amorphous thin Si films on SiO2. Experimentally, we report and elaborate on the isolated single-crystal disk structure that is observed at the upper threshold of the SLG regime; the structure is revealed as an important microstructural feature for understanding the phenomenon. A theoretical discussion of the SLG phenomenon is provided in terms of the key factors that are suggested by our model—the interface response function of the solid, the nucleation kinetics of the solid, and a highly transient lateral-thermal profile near the solid-melt interface. Our model and analysis point out the important inadequacies associated with the vertical solidification rate/temperature gradient model, which is currently being utilized to explain the excimer laser crystallization of thin Si films on SiO2.
Simulation and optimisation for management of intermodal terminals (1997)

... system for improving the management of intermodal container terminals. It is implemented as a modular architecture which integrates a forecasting model, a planner and a simulation module. While the forecasting module estimates container traffic, the planning module uses this information to generate efficient policies for storage, resource allocation and scheduling. The performance of management policies is assessed via computer simulation. Genetic algorithms, taboo search, and dynamic programming techniques are used to implement management policies. Some experimental results are presented.
Manipulation of charged residues within the two‐peptide lantibiotic lacticin 3147 (2009)

Lantibiotics are antimicrobial peptides which contain a high percentage of post-translationally modified residues. While most attention has been paid to the role of these critical structural features, evidence continues to emerge that charged amino acids also play a key role in these peptides. Here 16 'charge' mutants of the two-peptide lantibiotic lacticin 3147 [composed of Ltnα (2+, 2-) and Ltnβ (2+)] were constructed which, when supplemented with previously generated peptides, results in a total bank of 23 derivatives altered in one or more charged residues. When examined individually, in combination with a wild-type partner or, in some instances, in combination with one another, these mutants reveal the importance of charge at specific locations within Ltnα and Ltnβ, confirm the critical role of the negatively charged glutamate residue in Ltnα and facilitate an investigation of the contribution of positively charged residues to the cationic Ltnβ. From these investigations it is also apparent that the relative importance of the overall charge of lacticin 3147 varies depending on the target bacteria and is most evident when strains with more negatively charged cell envelopes are targeted. These studies also result in, for the first time, the creation of a derivative of a lacticin 3147 peptide (LtnβR27A) which displays enhanced specific activity.
ALD of High-κ Dielectrics on Suspended Functionalized SWNTs (2005)

Conformal atomic layer deposition (ALD) on as-grown suspended single-walled carbon nanotubes (SWNTs) is not possible due to the inertness of ALD precursor molecules to the SWNT surface. Here, we present a functionalization technique that makes SWNTs reactive with ALD precursors, and deposit high-κ oxides ( and ) onto the nanotubes to illustrate this method. Reactivity of the precursors with the functionalized nanotubes is due to - functional groups attached to the nanotube sidewalls. The effect of the functionalization on the nanotube conductance is shown to be reversible, and doping caused by the deposited oxides is discussed.