gebhart/patrepeval huggingface dataset:
Molecular identification and clinical features of enteroviral infection in children of central Korea: An overview of enteroviral epidemiology between spring 2005 and autumn 2006 (2009)

= Abstract = Purpose : Enteroviruses (EVs) are commonly known to cause infection, especially in infants and children. This report presents an overview of enterovirus epidemiology in central Korea. Methods : From the spring of 2005 to the autumn of 2006, we collected the cerebrospinal fluid (CSF) and stool samples from the pediatric patients with a febrile illness or suspected meningitis who were admitted to hospitals in central Korea. In order to test for EVs, cell lines were derived from pretreated susceptible specimen, and the cytopathic effects were observed. Seminested real time-polymerase chain reaction (RT-PCR) and direct sequencing were performed for genotypic and phylogenetic analyses. Results : Of the 305 patients examined, 51 (16.7%) tested positive for EV. Of these 51 patients, 44 showed the following serotypes: Echovirus (ECV) 18 (18 cases, 35.2%), Coxsackievirus B (CVB) 5 (13 cases, 25.4%), ECV25 (5 cases, 9.8%), ECV9 (4 cases, 7.8%), ECV5 (3 cases, 5.8%), and EV74 (1 case, 1.9%). In 2005, between June and August, ECV18 and CVB5 were mostly responsible for the enteroviral infections among the patients in central Korea. In 2006, between July and August, ECV25 was mostly the cause of enteroviral infection. Conclusions : There is a need for continuous surveillance of enteroviral infection and its clinical manifestations, particularly for EV74, which was first identified in Korea. (Korean J Pediatr 2009;52:1234-1240)
Hormone Therapy and Age-Related Macular Degeneration (2006)

Treatment with CEE alone or CEE + P does not affect early- or late-stage AMD. Treatment with CEE + P may reduce the risk of soft drusen or neovascular AMD.
Simultaneous solar-wind plasma and magnetic-field measurements in the expected region of the extended geomagnetic tail (1972)

A comparison is made of simultaneous plasma and magnetic-field measurements obtained by Pioneer 7 in the expected region of the geomagnetic tail at ∼1000 RE. The results indicate that, unlike the data for the near-earth (≤80 RE) geomagnetic tail, the data for the plasma and magnetic field have no unique signature of tail-associated phenomena. Furthermore, there are differences between the two types of data concerning the tentative identification of tail-associated phenomena for a number of intervals. The physical implications of these differences may be associated with anomalous transport properties that introduce turbulence in the form of mass diffusion and diamagnetic behavior adjacent to plasma eddies. As a result, the magnetopause, as it is recognized close to earth, loses its identity at far distances (>80 RE) and combines in a turbulent and hence ill-defined way with the geomagnetic tail. Thus there would be no reason to expect a consistent tail identification on a one-to-one basis with plasma and magnetic-field observations, the criterion presently used close to earth (i.e., <80 RE).
Fault Tolerant Approaches in Cloud Computing Infrastructures (2012)

Based on the pay-as-you-go strategy, cloud computing platforms are spreading very rapidly. One of the main characteristics of cloud computing is the splitting into many layers. From a technical point of view, most cloud computing platforms exploit virtualization, which implies that they are split into 3 layers: hosts, virtual machines and applications. From an administration point of view, they are split into 2 layers: the cloud provider who manages the hosting center and the customer who manages his application in the cloud. This structuring of cloud makes it difficult to implement effective management policies. This paper focuses on fault tolerance in cloud computing platforms and more precisely on autonomic repair in case of faults. It discusses the implications of this splitting in the implementation of fault tolerance. In most of current approaches, fault tolerance is exclusively handled by the provider or the customer, which leads to partial or inefficient solutions. Solutions, which involve a collaboration between the provider and the customer are much promising. We illustrate this discussion with experiments where exclusive and collaborative fault tolerance solutions are implemented in an autonomic cloud infrastructure that we prototyped. Keywords-Cloud Computing, Fault tolerance, Virtualisation.
Amplification and expression of the TGF-α, EGF receptor and c-myc genes in four human oesophageal squamous cell carcinoma lines (1993)

We have previously shown that four human oesophageal squamous cell carcinoma (SCC) cell lines secrete significant quantities of transforming growth factor alpha (TGF-alpha) in vitro. Three of these lines are known to produce supernumerary low-affinity epidermal growth factor receptors (EGF-Rs). Using an 125I-EGF competitive binding assay and Scatchard analysis, we show that the fourth also overproduces low-affinity receptors. According to slot blot DNA analyses, the secretion of high levels of TGF-alpha is not associated with amplification of the TGF-alpha gene, and hyperproduction of the EGF-R is correlated with receptor gene amplification. Western blot analyses show that the c-Myc protein is overexpressed in two of the cell lines; and Southern and Northern blot analyses indicate that this overexpression occurs independently of c-myc gene amplification. Our results are consistent with an autocrine role for TGF-alpha and EGF-R in oesophageal carcinogenesis and support the possibility that c-myc overexpression may be required for the in vivo tumourigenicity of cells that produce high levels of TGF-alpha and the EGF-R.
Kinetic effects on the ideal pressure-driven modes in an L=2 heliotron (2003)

The kinetic effects on the ideal ballooning and interchange/Mercier modes are studied in model equilibria for an L=2 heliotron, large helical device (LHD) [A. Iiyoshi et al., Nucl. Fusion 39, 1245 (1999)]. It is shown that the ion finite Larmor radius (FLR) effect stabilizes the modes with high toroidal mode number, n. On the other hand, the finite electron compressibility plays a double role, and stabilizes the low-n modes as the ideal magnetohydrodynamic (MHD) modes, while it destabilizes the high-n modes. It is discussed that the inclusion of the compressibility impacts the stability, and this effect is stronger in LHD than in a comparable tokamak, which is due to the larger magnitude of the local curvature. As a result of the competition between the FLR and the compressibility, it is shown in LHD that the low-n instabilities can become much weaker than that expected by the ideal MHD, while the high-n instabilities are prone to remain unstable near the plasma core region.
Discovery of an Obscured Broad-Line Region in the High-Redshift Radio Galaxy MRC 2025−218 (2000)

This Letter presents infrared spectra taken with the newly commissioned near-infrared spectrometer (NIRSPEC) on the Keck II telescope of the high-redshift radio galaxy MRC 2025-218 (z=2.63). These observations represent the deepest infrared spectra of a radio galaxy to date and have allowed for the detection of Hbeta, [O iii] lambdalambda4959, 5007, [O i] lambda6300, Halpha, [N ii] lambdalambda6548, 6583, and [S ii] lambdalambda6716, 6713. The Halpha emission is very broad (FWHM=9300 km s-1) and luminous (2.6x1044 ergs s-1), and it is very comparable to the line widths and strengths of radio-loud quasars at the same redshift. This strongly supports active galactic nucleus unification models linking radio galaxies and quasars, although we discuss some of the outstanding differences. The line [O iii] lambda5007 is extremely strong and has extended emission with large relative velocities toward the nucleus. We also derive that if the extended emission is due to star formation, each knot has a star formation rate comparable to a Lyman-break galaxy at the same redshift.
New applications for three-dimensional follow-up and quality control using optical impression systems and OraCheck. (2014)

Intraoral and extraoral scanning systems are continuously improving in terms of operational reliability and image quality. This creates new application options for the standard use of these systems in dental practice. Three-dimensional scans for volumetric and differential analysis of jaw position over time can be generated by superimposing partial or full-arch scans recorded at different time points. These analyses can be performed in a wide range of dental applications to compare and follow treatments or diagnoses over time. In this article, we will describe the indications and applications for OraCheck, a new software application that will be available to Cerec users in Spring 2014.
Management of Korean Frostbite Cases (1952)

Management of Korean Frostbite Cases William M. Douglas, M.C., U.S.N.R. William M. Douglas, M.C., U.S.N.R. Opinions expressed in this article are those of the author and do not necessarily reflect the policy of the Navy Department Search for other works by this author on: Oxford Academic Google Scholar The Military Surgeon, Volume 110, Issue 5, May 1952, Pages 333–337, https://doi.org/10.1093/milmed/110.5.333 Published: 01 May 1952
Crystal orientation dependencies on the ferroelectric properties of SrBi2Ta2O9, CaBi2Ta2O9 thin films fabricated by the R. F. magnetron sputtering technique (1997)

Abstract Crystal orientation of the SrBi2Ta2O9, CaBi2Ta2O9 thin films were controlled by the r.f. sputtering pressure. The Pt/SBTO/Pt capacitor having a c-axis oriented films shows P∗r-P⁁r=16.3 μC/cm2 and Ec=50kV/cm which is superior than the films showing polycrystalline structure. The surface morphologies of the SrBi2Ta2O9 thin films show two kinds of grains which was changed by the sputtering conditions.
ChemInform Abstract: Synthesis and Characterization of Ti3AlC2. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Thermochemical Conversion of Lignin for Fuels and Chemicals: A Review (2013)

Lignin is one of the biomass components potentially usable as renewable resource to produce fuels or chemicals. After separation from the lignocellulosic matrix, this macromolecule is nowadays essentially valorized by combustion in paper mills. If second generation ethanol is produced in the future from lignocellulosic biomass, some increasing reserves of lignin will be available in addition to the ones coming from the paper industry. The main thermochemical ways such as pyrolysis, solvolysis, hydrothermal conversion and hydroconversion considered for the valorization of the lignin are reviewed in this article.
Continuous Laryngeal Adductor Reflex Versus Intermittent Nerve Monitoring in Neck Endocrine Surgery (2020)

3 Laryngoscope, 131:230-236, 2021.
THE EFFECTS OF POSTLIGATION ADMINISTRATION OF ORG 6001 AND DISOPYRAMIDE ON EARLY ISCHAEMIA‐INDUCED ARRHYTHMIAS IN THE ANAESTHETIZED RAT (1982)

The effects of intravenous doses of Org 6001 and disopyramide (10 mg/kg) known to confer protection against early postligation-induced arrhythmias in the anaesthetized rat when given prophylactically, were assessed following postligation administration. When given 1 min after ligation both drugs greatly reduced the incidence of ventricular fibrilloflutter and completely prevented electrical deaths (45% in the controls). Protection was also seen when the drugs were given just before the expected onset of arrhythmias (4.5 min postligation).
Hiponatremia en pacientes adultos con lesión cerebral agudas (2016)

Las afecciones agudas del sistema nervioso central como los accidentes cerebrovasculares (ACV) y traumatismos de cráneo producen alteraciones en la homeostasis del sodio por diversos mecanismos. La hiponatremia es un fenómeno frecuente en la práctica clínica, constituye un desafío debido a la diversa etiología, las complicaciones de su evolución natural llegan a ser muy severas y hasta fatales. Objetivo: determinar la frecuencia y causas de hiponatremia en pacientes adultos con daño cerebral agudo internados en el Hospital Nacional. Materiales y metodos: estudio descriptivo, retrospectivo de corte trans­versal que incluyó 115 pacientes internados en el Hospital Nacional (Itauguá, Paraguay) en 2015. Se consideró como hiponatremia en cerebro agudo a los portadores de accidente cerebral vascular (ACV) hemorrágico (intra parenquimatoso, subaracnoideo o cerebro meníngeo), ACV isquémico o traumatismo de cráneo corroborados por tomografía axial computada de cráneo o resonancia magnética de menos de 10 días de evolución y hayan presentado Na sérico ≤ 135 mEq/L. Resultados: la prevalencia de hiponatremia fue 34%, con predominio del sexo masculino (54%). El diagnóstico más frecuente fue el ACV hemorrágico y la principal comorbilidad asociada fue la hipertensión arterial. Se diagnosticaron 15 pacientes con Síndrome de secreción inadecuada de hormona antidiurética y 6 con depleción cerebral de sal que representan 38,4% y 15,4% respectivamente. Conclusión: se halló alta prevalencia de hiponatremia en pacientes con daño cerebral agudo. El Síndrome de secreción inadecuada de hormona antidiurética y depleción cerebral de sal describen y explican con mayor frecuencia la presencia de hiponatremia asociada a natriuresis aumentada.
Blast Concussive Disorder at a United States Military Field Hospital in Iraq: A Neuro-otological Analysis (2006)

Xydakis, Michael S. M.D.; Bebarta, Vikhyat M.D.; Harrison, Corey M.D.; Conner, Jonathan M.D.; Grant, Gerald A. M.D.
Extreme Reconfigurable Nanoelectronics at the CaZrO3/SrTiO3 Interface (2018)

Complex oxide heterostructures have fascinating emergent properties that originate from the properties of the bulk constituents as well as from dimensional confinement. The conductive behavior of the polar/nonpolar LaAlO<sub>3</sub> /SrTiO<sub>3</sub> interface can be reversibly switched using conductive atomic force microscopy (c-AFM) lithography, enabling a wide range of devices and physics to be explored. Here, extreme nanoscale control over the CaZrO<sub>3</sub> /SrTiO<sub>3</sub> (CZO/STO) interface, which is formed from two materials that are both nonpolar, is reported. Nanowires with measured widths as narrow as 1.2 nm are realized at the CZO/STO interface at room temperature by c-AFM lithography. These ultrathin nanostructures have spatial dimensions at room temperature that are comparable to single-walled carbon nanotubes, and hold great promise for alternative oxide-based nanoelectronics, as well as offer new opportunities to investigate the electronic structure of the complex oxide interfaces. The cryogenic properties of devices constructed from quasi-1D channels, tunnel barriers, and planar gates exhibit gate-tunable superconductivity, quantum oscillations, electron pairing outside of the superconducting regime, and quasi-ballistic transport. This newly demonstrated ability to control the metal-insulator transition at nonpolar oxide interface greatly expands the class of materials whose behavior can be patterned and reconfigured at extreme nanoscale dimensions.
Regulation of BCR-mediated Ca 2+ mobilization by MIZ1-TIMBIM4 safeguards IgG1 + GC B cell positive selection (2023)

Summary The transition from IgM to affinity-matured IgG antibodies is vital for effective humoral immunity. This is facilitated by germinal centers (GCs) through affinity maturation and preferential accumulation of IgG + B cells over IgM + B cells. However, it is not known whether the positive selection of the different immunoglobulin isotypes within GCs varies in its dependency on specific transcriptional mechanisms. Here, we identified IgG1 + GC B cell transcription factor dependency using CRISPR-Cas9 and conditional mouse genetics. We found that MIZ1 was specifically required for IgG1 + GC B cell survival during positive selection, whereas IgM + GC B cells were largely independent. Mechanistically, MIZ1 induced TMBIM4, an ancestral anti-apoptotic protein that regulated inositol trisphosphate receptor mediated Ca 2+ mobilization downstream of IgG1. The MIZ1-TMBIM4 axis prevented mitochondrial dysfunction-induced IgG1 + GC cell death caused by excessive Ca 2+ accumulation. This study uncovers a unique immunoglobulin isotype-specific dependency, on a hitherto unidentified mechanism in GC positive selection.
Alzheimer neurofibrillary tangles: Antiserum and immunohistological staining (1979)

A 50,000-dalton polypeptide has been purified from fractions enriched with neurofibrillary tangles of paired helical filaments from human autopsy specimens of Alzheimer disease and senile dementia of the Alzheimer type. An antiserum to this polypeptide was raised in a rabbit. This antiserum formed an immunoprecipitation line with the purified antigen and with human neurotubules in ouchterlony double-diffusion plates. The reactivity of the anti-paired helical filament protein serum with neurofibrillary tangles was studied by immunofluorescence on cryostat sections of hippocampus from Alzheimer autopsy tissue and by the peroxidase-antiperoxidase technique on paraffin sections of an Alzheimer brain biopsy. The tangles were stained with the antiserum in both systems. Preimmune rabbit serum and unrelated hyperimmune sera, used as controls, did not stain the tangles. These results show that the 50,000-dalton polypeptide purified from the neurofibrillary tangle-enriched fractions is a constituent of Alzheimer neurofibrillary tangles and, perhaps, of the paired helical filaments of which the tangles are composed.
Robust Causal Transform Coding for LQG Systems with Delay Loss in\n Communications (2016)

A networked controlled system (NCS) in which the plant communicates to the\ncontroller over a channel with random delay loss is considered. The channel\nmodel is motivated by recent development of tree codes for NCS, which\neffectively translates an erasure channel to one with random delay. A causal\ntransform coding scheme is presented which exploits the plant state memory for\nefficient communications (compression) and provides robustness to channel delay\nloss. In this setting, we analyze the performance of linear quadratic Gaussian\n(LQG) closed-loop systems and the design of the optimal controller. The design\nof the transform code for LQG systems is posed as a channel optimized source\ncoding problem of minimizing a weighted mean squared error over the channel.\nThe solution is characterized in two steps of obtaining the optimized causal\nencoding and decoding transforms and rate allocation across a set of transform\ncoding quantizers. Numerical and simulation results for Gauss-Markov sources\nand an LQG system demonstrate the effectiveness of the proposed schemes.\n
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. (1992)

We report on the identification of a nuclear protein that serves as a dominant-negative inhibitor of the transcription factors C/EBP and LAP. A 32P-labeled LAP DNA-binding and dimerization domain "zipper probe" was used to isolate a clone that encodes a new C/EBP-homologous protein: CHOP-10. CHOP-10 has strong sequence similarity to C/EBP-like proteins within the bZIP region corresponding to the DNA-binding domain consisting of a leucine zipper and a basic region. Notably, however, CHOP-10 contains 2 prolines substituting for 2 residues in the basic region, critical for binding to DNA. Thus, heterodimers of CHOP-10 and C/EBP-like proteins are unable to bind their cognate DNA enhancer element. CHOP-10 mRNA is expressed in many different rat tissues. Antisera raised against CHOP-10 recognize a nuclear protein with an apparent molecular mass of 29 kD. CHOP-10 is induced upon differentiation of 3T3-L1 fibroblasts to adipocytes, and cytokine-induced dedifferentiation of adipocytes is preceded by the loss of nuclear CHOP-10. Coimmunoprecipitation of CHOP-10 and LAP from transfected COS-1 cells demonstrated a direct interaction between the two proteins, in vivo. Consistent with the structure of its defective basic region, bacterially expressed CHOP-10 inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA. In transfected HepG2 cells, expression of CHOP-10 attenuates activation of C/EBP- and LAP-driven promoters. We suggest that CHOP-10 is a negative modulator of the activity of C/EBP-like proteins in certain terminally differentiated cells, similar to the regulatory function of Id on the activity of MyoD and MyoD-related proteins important in the development of muscle cells.
Sparse Convolutional Networks using the Permutohedral Lattice. (2015)

This paper introduces an efficient, non-linear image adaptive filtering as a generalization of the standard spatial convolution of convolutional neural networks (CNNs). We build on the bilateral filtering operation, a commonly used edge-aware image processing technique. Our implementation of bilateral filters uses specialized data structures, and in this paper we demonstrate how these lead to generalizations and make the filters amendable to learning. This development enriches the convolutional operation found in CNNs, which becomes image adaptive, can process sparse input data, and produce continuous output. Our result also generalizes a class of densely connected graphical models with tractable mean field inference. It has previously been shown that mean field approximations in the subclass of models with Gaussian edge potentials reduce to a bilateral filtering operation. Here, we generalize this to the non-Gaussian case and allow highly parameterized potential functions. A diverse set of experiments validates the empirical performance and highlights the different aspects of the proposed operation.
Expression of FBN1 during adipogenesis: Relevance to the lipodystrophy phenotype in Marfan syndrome and related conditions (2016)

Fibrillin-1 is a large glycoprotein encoded by the FBN1 gene in humans. It provides strength and elasticity to connective tissues and is involved in regulating the bioavailability of the growth factor TGFβ. Mutations in FBN1 may be associated with depleted or abnormal adipose tissue, seen in some patients with Marfan syndrome and lipodystrophies. As this lack of adipose tissue does not result in high morbidity or mortality, it is generally under-appreciated, but is a cause of psychosocial problems particularly to young patients. We examined the role of fibrillin-1 in adipogenesis. In inbred mouse strains we found significant variation in the level of expression in the Fbn1 gene that correlated with variation in several measures of body fat, suggesting that mouse fibrillin-1 is associated with the level of fat tissue. Furthermore, we found that FBN1 mRNA was up-regulated in the adipose tissue of obese women compared to non-obese, and associated with an increase in adipocyte size. We used human mesenchymal stem cells differentiated in culture to adipocytes to show that fibrillin-1 declines after the initiation of differentiation. Gene expression results from a similar experiment (available through the FANTOM5 project) revealed that the decline in fibrillin-1 protein was paralleled by a decline in FBN1 mRNA. Examination of the FBN1 gene showed that the region commonly affected in FBN1-associated lipodystrophy is highly conserved both across the three human fibrillin genes and across genes encoding fibrillin-1 in vertebrates. These results suggest that fibrillin-1 is involved as the undifferentiated mesenchymal stem cells transition to adipogenesis but then declines as the developing adipocytes take on their final phenotype. Since the C-terminal peptide of fibrillin-1 is a glucogenic hormone, individuals with low fibrillin-1 (for example with FBN1 mutations associated with lipodystrophy) may fail to differentiate adipocytes and/or to accumulate adipocyte lipids, although this still needs to be shown experimentally.