gebhart/patrepeval huggingface dataset:
Data Illustrator (2018)

Building graphical user interfaces for visualization authoring is challenging as one must reconcile the tension between flexible graphics manipulation and procedural visualization generation based on a graphical grammar or declarative languages. To better support designers' workflows and practices, we propose Data Illustrator, a novel visualization framework. In our approach, all visualizations are initially vector graphics; data binding is applied when necessary and only constrains interactive manipulation to that data bound property. The framework augments graphic design tools with new concepts and operators, and describes the structure and generation of a variety of visualizations. Based on the framework, we design and implement a visualization authoring system. The system extends interaction techniques in modern vector design tools for direct manipulation of visualization configurations and parameters. We demonstrate the expressive power of our approach through a variety of examples. A qualitative study shows that designers can use our framework to compose visualizations.
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature upon SARS-CoV-2 sensing by monocytes in COVID-19 (2022)

Abstract Alterations in the myeloid immune compartment have been observed in COVID-19, but the specific mechanisms underlying these impairments are not completely understood. Here we examined the functionality of classical CD14 + monocytes as a main myeloid cell component in well-defined cohorts of patients with mild and moderate COVID-19 during the acute phase of infection and compared them to that of healthy individuals. We found that ex vivo isolated CD14 + monocytes from mild and moderate COVID-19 patients display specific patterns of costimulatory and inhibitory receptors that clearly distinguish them from healthy monocytes, as well as altered expression of histone marks and a dysfunctional metabolic profile. Decreased NFκB activation in COVID-19 monocytes ex vivo is accompanied by an intact type I IFN antiviral response. Subsequent pathogen sensing ex vivo led to a state of functional unresponsiveness characterized by a defect in pro-inflammatory cytokine expression, NFκB-driven cytokine responses and defective type I IFN response in moderate COVID-19 monocytes. Transcriptionally, COVID-19 monocytes switched their gene expression signature from canonical innate immune functions to a pro-thrombotic phenotype characterized by increased expression of pathways involved in hemostasis and immunothrombosis. In response to SARS-CoV-2 or other viral or bacterial components, monocytes displayed defects in the epigenetic remodelling and metabolic reprogramming that usually occurs upon pathogen sensing in innate immune cells. These results provide a potential mechanism by which innate immune dysfunction in COVID-19 may contribute to disease pathology.
Age-dependent consequences of seizures: Relationship to seizure frequency, brain damage, and circuitry reorganization (2000)

Seizures in the developing brain pose a challenge to the clinician. In addition to the acute effects of the seizure, there are questions regarding the impact of severe or recurrent seizures on the developing brain. Whether provoked seizures cause brain damage, synaptic reorganization, or epilepsy is of paramount importance to patients and physicians. Such questions are especially relevant in the decision to treat or not treat febrile seizures, a common occurrence in childhood. These clinical questions have been addressed using clinical and animal research. The largest prospective studies do not find a causal connection between febrile seizures and later temporal lobe epilepsy. The immature brain seems relatively resistant to the seizure-induced neuronal loss and new synapse formation seen in the mature brain. Laboratory investigations using a developmental rat model corresponding to human febrile seizures find that even though structural changes do not result from hyperthermic seizures, synaptic function may be chronically altered. The increased understanding of the cellular and synaptic mechanisms of seizure-induced damage may benefit patients and clinicians in the form of improved therapies to attenuate damage and changes induced by seizures and to prevent the development of epilepsy.
A programmable true piecewise approximation logarithmic amplifier (2009)

This paper describes the operation theory, mathematical analysis and simulation of parallel summation type of the true piecewise approximation logarithmic amplifiers. It also reports a programmable logarithmic amplifier to have a desired logarithmic characteristic in special applications. To design the programmable structure, mathematical analysis of parallel summation type of the true piecewise approximation logarithmic amplifier is performed and based on it, a new method for improving its characteristic and some methods for adding flexibility and programmability to the structure is described. The presented programmable logarithmic architecture can be used in applications with variant and uncertain input signal range such as wide range wireless receivers and radar applications and some analog signal processing applications.
Template Catalysis by Metal–Ligand Cooperation. C–C Bond Formation via Conjugate Addition of Non-activated Nitriles under Mild, Base-free Conditions Catalyzed by a Manganese Pincer Complex (2016)

The first example of a catalytic Michael addition reaction of non-activated aliphatic nitriles to α,β-unsaturated carbonyl compounds under mild, neutral conditions is reported. A new de-aromatized pyridine-based PNP pincer complex of the Earth-abundant, first-row transition metal manganese serves as the catalyst. The reaction tolerates a variety of nitriles and Michael acceptors with different steric features and acceptor strengths. Mechanistic investigations including temperature-dependent NMR spectroscopy and DFT calculations reveal that the cooperative activation of alkyl nitriles, which leads to the generation of metalated nitrile nucleophile species (α-cyano carbanion analogues), is a key step of the mechanism. The metal center is not directly involved in the catalytic bond formation but rather serves, cooperatively with the ligand, as a template for the substrate activation. This approach of "template catalysis" expands the scope of potential donors for conjugate addition reactions.
Lipid-free versus lipid-bound P2 protein-induced experimental allergic neuritis: Clinicopathological, neurophysiological, and immunological study (2000)

The P2 protein of the peripheral nervous system myelin is a neuritogenic protein capable of inducing experimental allergic neuritis (EAN) in the Lewis rat. It has been suggested that the addition of some lipids to the protein isolated in the lipid-free form might enhance its immunogenicity. In this study, we compared lipid-free P2 (the EAN factor) and the corresponding lipid-bound form of the protein regarding their ability to induce EAN. Lipid-bound P2, copurified with all the myelin lipids, shows a conformation different from that of LF-P2. The timing of disease and the clinical scores of lipid-bound P2-induced EAN animals (n = 23) did not differ statistically from those injected with lipid-free P2 (n = 23), with only a tendency to higher clinical severity in the former group. Tail nerve conduction velocities did not differ in the two groups and in both were significantly lower in comparison to Freund adjuvant controls (n = 8). Inflammation and demyelination predominated in the spinal roots and were less evident in the sciatic nerve for both groups of animals. The ELISA determination of antibodies to lipid-free and lipid-bound P2 revealed the development of antibodies recognizing the lipid-free form of the protein in both groups of animals. Our results stand in contrast to results of previous studies performed after addition of exogenous lipids to the P2 purified in the lipid-free form and indicate that lipid-bound P2 is not significantly more immunogenic than lipid-depleted P2.
The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway (2015)

The CB1 cannabinoid receptor, the main molecular target of endocannabinoids and cannabis active components, is the most abundant G protein-coupled receptor in the mammalian brain. In particular, the CB1 receptor is highly expressed in the basal ganglia, mostly on terminals of medium-sized spiny neurons, where it plays a key neuromodulatory function. The CB1 receptor also confers neuroprotection in various experimental models of striatal damage. However, the assessment of the physiological relevance and therapeutic potential of the CB1 receptor in basal ganglia-related diseases is hampered, at least in part, by the lack of knowledge of the precise mechanism of CB1 receptor neuroprotective activity. Here, by using an array of pharmacological, genetic and pharmacogenetic (designer receptor exclusively activated by designer drug) approaches, we show that (1) CB1 receptor engagement protects striatal cells from excitotoxic death via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin complex 1 pathway, which, in turn, (2) induces brain-derived neurotrophic factor (BDNF) expression through the selective activation of BDNF gene promoter IV, an effect that is mediated by multiple transcription factors. To assess the possible functional impact of the CB1/BDNF axis in a neurodegenerative-disease context in vivo, we conducted experiments in the R6/2 mouse, a well-established model of Huntington's disease, in which the CB1 receptor and BDNF are known to be severely downregulated in the dorsolateral striatum. Adeno-associated viral vector-enforced re-expression of the CB1 receptor in the dorsolateral striatum of R6/2 mice allowed the re-expression of BDNF and the concerted rescue of the neuropathological deficits in these animals. Collectively, these findings unravel a molecular link between CB1 receptor activation and BDNF expression, and support the relevance of the CB1/BDNF axis in promoting striatal neuron survival.
Improvement of the fermentation performance of Lactobacillus plantarum by the flavanol catechin is uncoupled from its degradation (2010)

This study, for the first time, examined the influence of the flavanol catechin on the fermentation performance of a Lact. plantarum strain in several media under different fermentation conditions. The information could be relevant to control the production and obtain high-quality food products fermented by this micro-organism.
Integrity measurement of hardware based on TPM (2010)

In the trusted computing platform, trust is typically established solely based on software measurements. Few works consider the trust of platform hardware. However, hardware trust is pretty important to a trusted computing platform. In this paper, we propose the notion of measuring hardware trust and introduce the defintion of hardware integrity measurement, which is similar to the software integrity measurement required by the Trusted Computing Group. Its purpose is to collect and measure integrity of the whole platform hardware devices. Thus, to measure and collect integrity information of platform hardware devices, we propose the hardware integrity measurem-ent protocol and analyze how the protocol could defend those attacks. Finally, we conclude that trust of platform hardware is pretty important, and shares of research attentions are deserved.
Fluorine Chemistry. Volume II. (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorine Chemistry. Volume II.George H. CadyCite this: J. Am. Chem. Soc. 1955, 77, 16, 4440Publication Date (Print):August 1, 1955Publication History Published online1 May 2002Published inissue 1 August 1955https://pubs.acs.org/doi/10.1021/ja01621a095https://doi.org/10.1021/ja01621a095research-articleACS PublicationsRequest reuse permissionsArticle Views34Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Architecture centric coarse-grained FPGA overlays (2017)

Coarse-grained FPGA overlays have emerged as one possible solution to make FPGAs more accessible to application developers who are accustomed to software API abstractions and fast development cycles. Existing overlay architectures offer a number of advantages for general purpose hardware acceleration because of software-like programmability, fast compilation, application portability, and improved design productivity, but at the cost of area and performance overheads due to limited consideration for the underlying FPGA architecture. This thesis explores coarse grained overlays designed using the exible DSP48E1 primitive on Xilinx FPGAs, allowing pipelined execution of compute kernels at significantly higher throughput. We first evaluate an open source overlay architecture, DySER, mapped on the Xilinx Zynq device and show that DySER suffers from a significant area and performance overhead due to limited consideration for the underlying FPGA architecture. Next, we design and implement a more FPGA targeted overlay architecture that maximizes the peak performance and reduces the interconnect area overhead through the use of an array of DSP block based fully pipelined functional units and an island-style coarse-grained routing network. As the interconnect of the island-style overlay is still excessive, we next explore novel interconnect architectures to further reduce the interconnect area. We next develop DeCO, a cone shaped cluster of FUs, which shows 87% savings in LUT requirements compared to our island-style overlay, for a set of compute kernels. Our experimental evaluation shows that the proposed overlays exhibit frequencies close to the DSP theoretical limit and achieve high performance with significantly reduced area overheads. We also present a methodology for compiling high level language (C/OpenCL) descriptions of compute kernels onto DSP block based coarse-grained overlays. Our mapping ow provides a rapid, vendor independent mapping to the overlay, raising the abstraction level while also reducing compilation time significantly, hence addressing the design productivity issue.
Does Consulting an Occupational Medicine Specialist Decrease Time to Return to Work Among Total Knee Arthroplasty Patients? A 12-Month Prospective Multicenter Cohort Study (2022)

Consulting an OMS within 3 months after surgery did not result in a decrease in time to RTW in TKA patients. TKA patients with high expectations did RTW earlier without consulting an OMS. Intervention studies on how OMSs can positively influence a timely RTW, incorporating patients' preoperative expectations, are needed.
Wavelength Dependent and Adiabatic Photochemistry of Endoperoxides of Aromatic Hydrocarbons (1982)

Abstract The photochemical cleavage of the endoperoxides of anthradichromene and benzodixanthene into the parent hydrocarbon and oxygen is shown to be an adiabatic photoreaction originating from an upper excited singlet state. This photochemical behaviour is described by a theory for the photochemistry of endoperoxides developed by Kearns and Khan.
Beam-splitting ZnSe diffractive optical element (2003)

ZnSe Diffractive Optical Element (DOE) is one of the advanced optics which utilizes the optical diffraction phenomena by fabricating a micron order pattern on polished mirror-like surface of ZnSe polycrystal substrate. Various applications for a carbon dioxide (CO<sub>2</sub>) laser material processing such as beam-splitting, beam-shaping and beam-homogenizing are available. The micro pattern of ZnSe DOE is fabricated by the photolithography and reactive ion etching (RIE) technique. Its optical property is highly dependent on the depth precision of microfabricated pattern. In RIE by using BCl3 as the etchant gas we have achieved an etching technique to maintain the smooth surface of the ZnSe polycrystal with minimal etching rate dependency on the crystal orientation of each crystal grain. The surface roughness is 2nm Ra before etching and 5 nm Ra after about 4 microns depth etching. This good roughness brings better depth precision. With these etching technique beam-splitting ZnSe DOE with less than 10% intensity uniformity of splitted beams is successfully obtained and it can be put to use for practical CO<sub>2</sub> laser hole drilling.
Anatomy of Facial Recipient Sites for Autologous Fat Transfer (2003)

Introduction: Autologous fat transfer is an increasingly popular treatment for the aging face. Recently, studies have suggested increased duration of effect with the injection of fat into or adjacent to muscles. Subcutaneous depths of facial muscles have been demonstrated using cadaver dissections, but to our knowledge this is the first study to use radiologic measurements in living subjects in order to quantify muscle depths in the face. Materials and Methods: Forty computed tomography (CT) scans were reviewed retrospectively using digital radio imaging software with a calibrated digital measurement tool that was used to measure the depths of the muscles of facial expression corresponding to fat-grafting sites. Correlation was made to formalin-preserved cadaver dissections. Results: Subcutaneous depths of facial muscles are listed as measured radio graphically and on cadaver sections. Discussion: The depths of the muscles of facial expression are more accurately measured using digital radiographs; these depths are important landmarks for facial cosmetic surgeons performing an autologous fat transfer. To our knowledge, this is the first study to characterize the anatomic depth of the facial muscles in the living human.
Learning Parametric Models for Context-Aware Query Auto-Completion via Hawkes Processes (2017)

Query auto completion (QAC) is a prominent feature in modern search engines. High quality QAC substantially improves search experiences by helping users in typing less while submitting the queries. Many studies have been proposed to improve quality and relevance of the QAC methods from different perspectives, including leveraging contexts in long term and short term query histories, investigating the temporal information for time-sensitive QAC, and analyzing user behaviors. Although these studies have shown the context, temporal, and user behavior data carry valuable information, most existing QAC approaches do not fully exploit or even completely ignore these information. We propose a novel Hawkes process based QAC algorithm, comprehensively taking into account the context, temporal, and position of the clicked recommended query completions (a type of user behavior data), for reliable query completion prediction. Our understanding of ranking query completions is consistent with the mathematical rationale of Hawke process; such a coincidence in turn validates our motivation of using Hawkes process for QAC. We also develop an efficient inference algorithm to compute the optimal solutions of the proposed QAC algorithm. The proposed method is evaluated on two real-world benchmark data in comparison with state-of-art methods, and the obtained experiments clearly demonstrate their effectiveness.
Racemicvs.enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines (2018)

A tetrakis(phenolato) Ti(iv) complex was synthesized in racemic and optically pure form, exhibiting high hydrolytic stability, and similar cytotoxicity for all stereochemical forms on HT-29 and A2780 cancer cells. Higher activity of the racemate on drug-resistant A2780cp and A2780adr lines implies a beneficial activity of both enantiomers rendering enantiomeric resolution unnecessary.
Zebrafish Galectin 3 binding protein is the target antigen of the microglial 4C4 monoclonal antibody (2022)

The 4C4 monoclonal antibody recognizes Lgals3bpb, a predicted highly glycosylated protein whose function in the microglial lineage is currently unknown. Identification of Lgals3bpb as a new pan-microglia marker will be fundamental in forthcoming studies using the zebrafish model.
Expression of a Ribosomal Protein Gene in Axillary Buds of Pea Seedlings (1992)

Axillary buds of intact pea seedlings (Pisum sativum L. cv Alaska) do not grow and are said to be dormant. Decapitation of the terminal bud promotes the growth of these axillary buds, which then develop in the same manner as terminal buds. We previously showed that unique sets of proteins are expressed in dormant and growing buds. Here we describe the cloning, sequencing, and expression of a cDNA clone (pGB8) that is homologous to ribosomal protein L27 from rat. RNA corresponding to this clone increases 13-fold 3 h after decapitation, reaches a maximum enhancement of about 35-fold after 12 h, and persists at slightly reduced levels at later times. Terminal buds, root apices, and elongating internodes also contain pGB8 mRNA but fully expanded leaflets and fully elongated internodes do not. In situ hybridization analysis demonstrates that pGB8 mRNA increases in all parts of the bud within 1 h of decapitation. Under appropriate conditions, growing buds can be made to stop growing and become dormant; these buds subsequently can grow again. Therefore, buds have the capacity to undergo multiple cycles of growth and dormancy. RNA gel blots show that pGB8 expression is reduced to dormancy levels as soon as buds stop growing. However, in situ hybridization experiments show that pGB8 expression continues at growing-bud levels in the apical meristem for 2 d after it is reduced in the rest of the bud. When cultured stems containing buds are treated with indoleacetic acid at concentrations >/=10 mum, bud growth and expression of pGB8 in the buds are inhibited.
Mutations affecting the serpentine domain of the TSHr can active the receptor by two independent mechanisms (2001)

info:eu-repo/semantics/nonPublished
Pancreatic exocrine insufficiency in diabetes mellitus (2023)

Diabetes is disease of both the endo- and exocrine parts of the pancreas. Pancreatic exocrine insufficiency (PEI) can occur in every 2–3 patients with diabetes and affect not only the quality, but also life expectancy. At the same time, the diagnosis and treatment of PEI is not getting enough attention. The endocrinologist, as the main specialist leading patients with diabetes, can diagnose and treat patients with pancreatic exocrine insufficiency and diabetes using adequate doses of pancreatic enzyme replacement therapy (PERT).