gebhart/patrepeval huggingface dataset:
Real-Time System Identification of a Nonlinear Four-Story Steel Frame Structure—Application to Structural Health Monitoring (2009)

Structural health monitoring (SHM) is a means of identifying damage from structural response to environmental loads. Real-time SHM is of particular use for rapid assessment of structural safety by owners and civil defense authorities. This paper presents an algorithm for real-time SHM during earthquake events using only acceleration measurements and infrequently measured displacement motivated by global positioning system. The algorithm identifies a nonlinear baseline model including hysteretic dynamics and permanent deformation using convex integral-based fitting methods and piecewise linear least squares fitting. The methodology identifies pre and postyield stiffness, elastic and plastic components of displacement, and final residual displacement. It thus identifies key measures of damage affecting the immediate safety or use of the structure and the long-term cost of repair and retrofit. The algorithm is tested with simulated response data using the El-Centro earthquake record and with measured response data. Both data sets are based on a four-story nonlinear steel frame structure using the El-Centro ground motion record. Overall, the algorithm is shown to provide accurate indications of the existence, location, and magnitude of structural damage for nonlinear shear-type buildings. Additionally, the identified permanent displacement is a particularly useful damage measure for the construction of probabilistic fragility functions.
The Role of Senior Thesis in the Curriculum of Mechanical Systems Engineering Course at Kumamoto University (2012)

We introduce the curriculum of mechanical systems engineering course at Kumamoto University, putting a stress upon the role of senior thesis in engineering education. After showing our system of supervising thesis and the framework of assessment of thesis, we devote a short discussion concerning the effectiveness of senior thesis in the development of student’ s potential.
Economic lifetime of a drilling machine: a case study on mining industry (2015)

Underground mines use many different types of machinery during the drift mining processes of drilling, charging, blasting, loading, scaling and bolting. Drilling machines play a critical role in the mineral extraction process and thus are important economically. However, as the machines age, their efficiency and effectiveness decrease, negatively affecting productivity and profitability and increasing total cost. Hence, the economic replacement lifetime of the machine is a key performance indicator. This paper introduces an optimisation model that gives the optimal lifetime for a drilling machine. A case study has been done at an underground Swedish mine to identify the economic replacement time of a drilling machine. It considers the purchase price, maintenance and operation costs, and the machine's second-hand value. Findings show that the economic replacement lifetime of a drilling machine in this mine is 96 months. The proposed model can be used for other underground mining machines.
Communication using Synchronization of Chaos in Semiconductor Lasers with optoelectronic feedback (2002)

A communication scheme based on the synchronization of two chaotic semiconductor lasers is experimentally tested. The Chaos in the single‐mode semiconductor lasers is generated by means of an optoelectronic feedback. Synchronization of the chaos is achieved by coupling a fraction of the transmitter’s output power into the driving current of the receiver. We present experimental results on the route to chaos and the synchronization of GHz chaotic signals. We then test a proposed communication scheme by successfully transmitting messages.
Bis(imino)pyridine Cobalt-Catalyzed Alkene Isomerization–Hydroboration: A Strategy for Remote Hydrofunctionalization with Terminal Selectivity (2013)

Bis(imino)pyridine cobalt methyl complexes are active for the catalytic hydroboration of terminal, geminal, disubstituted internal, tri- and tetrasubstituted alkenes using pinacolborane (HBPin). The most active cobalt catalyst was obtained by introducing a pyrrolidinyl substituent into the 4-position of the bis(imino)pyridine chelate, enabling the facile hydroboration of sterically hindered substrates such as 1-methylcyclohexene, α-pinene, and 2,3-dimethyl-2-butene. Notably, these hydroboration reactions proceed with high activity and anti-Markovnikov selectivity in neat substrates at 23 °C. With internal olefins, the cobalt catalyst places the boron substituent exclusively at the terminal positions of an alkyl chain, providing a convenient method for hydrofunctionalization of remote C-H bonds.
Genetic Polymorphisms of β1 Adrenergic Receptor and Their Influence on the Cardiovascular Responses to Metoprolol in a South Indian Population (2008)

The increase in cardiac responses to treadmill test was influenced by Ser49Gly polymorphism. Nevertheless, the above polymorphisms did not alter the beta-blocker response during treadmill exercise in South Indian population.
AUSTRALIAN CANCER MORTALITY FROM 1950 TO 1977: ANALYSIS OF THE NATIONAL MORTALITY STATISTICS (1980)

Australian cancer mortality from 1950 to 1977 has been analysed for trend. While mortality rates from "all causes" in both sexes are declining, there has been little decline in mortality rates from all malignant neoplasms in women, and an actual increase in male rates. Most notable are the increasing death rates from cancer of the lung, and declining death rates from cancer of the cervix.
Optical Generation of Tunable Microwave Signal Using Cascaded Brillouin Fiber Lasers (2011)

We propose and demonstrate an all-fiber scheme to generate a precisely tunable microwave signal by heterodyning the two cascaded single-frequency Brillouin fiber lasers (BFLs). The generated microwave frequency is equivalent to the offset between the first- and the second-order Stokes frequencies. The ~10 GHz generated signal exhibits high stability with a linewidth of 2.8 KHz. By controlling elastic strain to the fiber in the BFL, the microwave frequency can be tuned up to 270 MHz. Owing to frequency pulling effect (FPE) in BFL, the signal frequency can be continuously tuned in a range of 9.6 MHz within one free-spectral range (FSR) of 19.8 MHz, and the tuning accuracy is 100 KHz.
Prophylactic vaccines, risk behavior change, and the probability of eradicating HIV in San Francisco (1994)

Theory is linked with data to assess the probability of eradicating human immunodeficiency virus (HIV) in San Francisco through the use of prophylactic vaccines. The necessary vaccine efficacy levels and population coverage levels for eradication are quantified. The likely impact of risk behavior changes on vaccination campaigns is assessed. The results show it is unlikely that vaccines will be able to eradicate HIV in San Francisco unless they are combined with considerable reductions in risk behaviors. Furthermore, if risk behavior increases as the result of a vaccination campaign, then vaccination could result in a perverse outcome by increasing the severity of the epidemic.
Automatic singularity avoidance using joint variations in robot task modification (1994)

The research community has addressed the need to improve the flexibility of robot systems. Two particular concepts that have resulted from this research are off-line programming and modular tooling. These concepts are directed at allowing the robot system to be used to perform a variety of tasks with minimal setup time and to allow easy replication of an application. Both of these concepts require that the robot system have the ability to measure the position and orientation of features in the workspace. These measurements can then be used to perform coordinate transformations on each of the task data points. These modified task data points then, theoretically, facilitate the performance of the task by the robot system without human intervention.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A CASE OF DIEULAFOY ULCER OF THE COLON (1995)

This paper describes an extremely rare case of Dieulafoy ulcer of the colon. A 77-year-old woman was seen at the hospital because of abrupt massive melena. Emergency barium emema study revealed a localized ulcer with irregular wall with the dimeter of 7 cm in the descending colon. After antishock treatment endoscopy revealed a slightly yellowish, uneven depressed surface in the descending colon, with exposed vessels and adhesion of clots partially. Rebleeding occurred. Partial colectomy was carried out. The ulcer was about 7mm in size, of which surrounding mucosa lacked so-called inflammatory change which is commonly associated with ulcer, though exposed arteries were seen partially. Histopathologically the proper muscle layer teared from side to side, but no change indicative of deep ulcer was found. Normal colonic mucosa which seemed to be adjacent to the lesion was confirmed, and there was dilated abnormal hypervascularization in the submucosal layer. The patient was diagnosed as Dieulafoy ulcer of the colon. Dieulafoy ulcer is commonly found in the stomach, and rarely in the colon.
Controlling the shape and topology of two-component colloidal membranes (2022)

Changes in the geometry and topology of self-assembled membranes underlie diverse processes across cellular biology and engineering. Similar to lipid bilayers, monolayer colloidal membranes have in-plane fluid-like dynamics and out-of-plane bending elasticity. Their open edges and micrometer-length scale provide a tractable system to study the equilibrium energetics and dynamic pathways of membrane assembly and reconfiguration. Here, we find that doping colloidal membranes with short miscible rods transforms disk-shaped membranes into saddle-shaped surfaces with complex edge structures. The saddle-shaped membranes are well approximated by Enneper's minimal surfaces. Theoretical modeling demonstrates that their formation is driven by increasing the positive Gaussian modulus, which in turn, is controlled by the fraction of short rods. Further coalescence of saddle-shaped surfaces leads to diverse topologically distinct structures, including shapes similar to catenoids, trinoids, fournoids, and higher-order structures. At long timescales, we observe the formation of a system-spanning, sponge-like phase. The unique features of colloidal membranes reveal the topological transformations that accompany coalescence pathways in real time. We enhance the functionality of these membranes by making their shape responsive to external stimuli. Our results demonstrate a pathway toward control of thin elastic sheets' shape and topology-a pathway driven by the emergent elasticity induced by compositional heterogeneity.
Automatic Annotation of Structured Facts in Images (2016)

Motivated by the application of fact-level image understanding, we present an automatic method for data collection of structured visual facts from images with captions. Example structured facts include attributed objects (e.g., <flower, red>), actions (e.g., <baby, smile>), interactions (e.g., <man, walking, dog>), and positional information (e.g., <vase, on, table>). The collected annotations are in the form of fact-image pairs (e.g.,<man, walking, dog> and an image region containing this fact). With a language approach, the proposed method is able to collect hundreds of thousands of visual fact annotations with accuracy of 83% according to human judgment. Our method automatically collected more than 380,000 visual fact annotations and more than 110,000 unique visual facts from images with captions and localized them in images in less than one day of processing time on standard CPU platforms. We will make the data publically available.
Serine 1283 in extracellular matrix glycoprotein Reelin is crucial for Reelin’s function in brain development (2022)

Abstract Deficiency in the extracellular matrix glycoprotein Reelin severely affects migration of neurons during development. The function of serine at position 1283 in Reelin has remained uncertain. To explore its relevance we generated rln A/A mice that carry alanine instead of serine at position 1283, thereby disrupting the putative casein kinase 2 (CK2) phosphorylation site S 1283 DGD. Mutated mice displayed reeler -like locomotor behavior, abnormal brain anatomy and decrease of Reelin RNA and protein levels during development and in adulthood. Since serine 1283 was previously proposed to mediate proteolysis of adhesion molecules, we investigated proteolysis of cell adhesion molecule L1 and found it normal in rln A/A mice. Neuronal migration in the embryonic rln A/A cerebral cortex was impaired, but rescued by in utero electroporation of the Reelin fragment N-R6 containing the putative CK2 phosphorylation site. In rln A/A mice migration of cerebellar granule cells in vitro was promoted by application of wild-type but not by mutated Reelin. In cerebellar neuron cultures, Reelin expression was decreased upon inhibition of ecto-phosphorylation by CK2. Biochemically purified wild-type, but not mutated Reelin was found phosphorylated. Altogether, the results indicate that ecto-phosphorylation at serine 1283 rather than proteolytic processing of adhesion molecules by Reelin plays an important role in Reelin functions.
Video 1 from Impact of Metabolic Heterogeneity on Tumor Growth, Invasion, and Treatment Outcomes (2023)

&lt;p&gt;Video 1: Tumor growth. Simulation of untreated tumor growth&lt;/p&gt;
Characteristics, deposition, and fate of inhaled particulate matter (1986)

Accurate estimates of absorption and fate for particulate matter in the respiratory tract are difficult because of complexities in particle composition and morphology. Several deficiencies in information further complicate the ability to make accurate estimates. Available models for making estimates range from single models based on assumed particle size distribution to more-complex models based on a variety of parameters. Most work in the area of estimating particle fate following inhalation has been done on aerosols of known composition. Additional work is needed to categorize properties of inhalable particles with respect to composition in addition to morphology. Additional research is needed to define the effects of pulmonary disease on particle clearance from the lung. Additional research also is needed to better explain the mechanics of clearance from the pulmonary region of the lung.
Bowman’s capsule provides a protective niche for podocytes from cytotoxic CD8+ T cells (2018)

T cells play a key role in immune-mediated glomerulonephritis, but how cytotoxic T cells interact with podocytes remains unclear. To address this, we injected EGFP-specific CD8+ T cells from just EGFP death inducing (Jedi) mice into transgenic mice with podocyte-specific expression of EGFP. In healthy mice, Jedi T cells could not access EGFP+ podocytes. Conversely, when we induced nephrotoxic serum nephritis (NTSN) and injected Jedi T cells, EGFP+ podocyte transgenic mice showed enhanced proteinuria and higher blood urea levels. Morphometric analysis showed greater loss of EGFP+ podocytes, which was associated with severe crescentic and necrotizing glomerulonephritis. Notably, only glomeruli with disrupted Bowman's capsule displayed massive CD8+ T cell infiltrates that were in direct contact with EGFP+ podocytes, causing their apoptosis. Thus, under control conditions with intact Bowman's capsule, podocytes are not accessible to CD8+ T cells. However, breaches in Bowman's capsule, as also noted in human crescentic glomerulonephritis, allow access of CD8+ T cells to the glomerular tuft and podocytes, resulting in their destruction. Through these mechanisms, a potentially reversible glomerulonephritis undergoes an augmentation process to a rapidly progressive glomerulonephritis, leading to end-stage kidney disease. Translating these mechanistic insights to human crescentic nephritis should direct future therapeutic interventions at blocking CD8+ T cells, especially in progressive stages of rapidly progressive glomerulonephritis.
A Semantics-Aware Communication Scheme to Estimate the Empirical Measure of A Quantity of Interest Via Multiple Access Fading Channels (2021)

In this paper, we address semantics-empowered communication strategies that simultaneously incorporate semantic aware active sampling and transmission over a shared communication medium. We consider a setting where the goal is to devise a joint sampling and communication scheme over a wireless multiple access channel (MAC) that enables to compute the empirical probability measure of a quantity of interest (QoI) at the destination. We conceptualize a simple application example that illustrates the potential of the approach to provide scalable and resource-efficient operation in massive connectivity settings. We numerically assess the performance of the scheme against an upper bound derived under the assumption that direct access to the noise-free measurements is provided at the destination.
Vinylation of silanes and disiloxanes. Preparation of hexavinyldisiloxane (2013)

Vinylation of silanes and disiloxanes has been studied. It has been shown that in the reactions of silanes with vinyl chloride and magnesium or sodium the sole product formed is tetravinylsilane. In the reactions of hexaethoxydisiloxane with vinyl chloride and magnesium, tetravinylsilane is the sole product formed. Hexavinyldisiloxane with yield up to 85% is formed in the reaction of hexaethoxydisiloxane with vinyl chloride and magnesium in the presence of copper(II) salts as alkylation catalyst.
Enabling semantic communications for virtual machines via iConnect (2007)

iConnect is an abstraction that encapsulates all of a virtual machine's interactions with outside entities. Its intent is to exploit semantic information to better support the end-to-end requirements of such VM communications. Focusing on the I/O performed by VMs and leveraging the fact that modern systems already have to virtualize the physical devices used by VMs, this paper shows that the iConnect abstraction can be implemented with the extension of existing virtual device interfaces. Specifically, by devising enhanced virtual devices, we can (1) efficiently implement the communication paths between virtual machines (VMs) and the virtualized platforms (VPs) on which they run, and (2) capture semantic information about VM-device interactions, which can then be used to implement additional functionality and efficient sharing of physical devices. The paper presents three concrete realizations of the iConnect abstraction: a multimedia device virtualization solution (VMedia) which utilizes semantic information to implement efficient sharing and enhanced functionality, a network virtualization solution that provides virtual NICs with QoS-support where the VM communicates its QoS requirements to the VP, and a storage virtualization solution which permits a VM to access a block device regardless of whether such a device is physically located locally or must be accessed at a remote location. A Xen-based implementation of the iConnect concept demonstrates substantial performance improvements and additional functionality derived from their use at a minimal cost to VMs, in part because iConnect utilizes additional computational resources of the VP and can take better advantage of certain underlying platform capabilities.
DNA Binding and Transactivation Characteristics of the Mosquito Ecdysone Receptor-Ultraspiracle Complex (1998)

The steroid hormone 20-hydroxyecdysone is a key regulatory factor, controlling blood-meal triggered egg maturation in mosquitoes. To elucidate the ecdysone hierarchy governing this event, we cloned and characterized the ecdysone receptor (AaEcR) and the nuclear receptor Ultraspiracle (AaUSP), a retinoid X receptor homologue, from the mosquito, Aedes aegypti, which form a functional complex capable of ligand and DNA binding. Here we analyzed the DNA-binding properties of the AaEcR.AaUSP heterodimer with respect to the effects of nucleotide sequence, orientation, and spacing between half-sites in natural Drosophila and synthetic ecdysone response element (EcREs). By using an electrophoretic gel mobility shift assay, we showed that AaEcR.AaUSP exhibits a broad binding specificity, forming complexes with inverted (IR) and direct (DR) repeats of the nuclear receptor response element half-site consensus sequence AGGTCA separated by spacers of variable length. A single nucleotide spacer was optimal for both imperfect (IRhsp-1) and perfect (IRper-1) inverted repeats; adding or removing 1 base pair in an IRhsp-1 spacer practically abolished binding. However, changing the half-site to the consensus sequence AGGTCA (IRper-1) increased binding of AaEcR.AaUSP 10-fold over IRhsp-1 and, at the same time, reduced the stringency of the spacer length requirement, with IRper-0 to IRper-5 showing detectable binding. Spacer length was less important in DRs of AGGTCA (DR-0 to DR-5); although 4 bp was optimal, DR-3 and DR-5 bound AaEcR.AaUSP almost as efficiently as DR-4. Furthermore, AaEcR. AaUSP also bound DRs separated by 11-13 nucleotide spacers. Competition experiments and direct estimation of binding affinity (Kd) indicated that, given identical consensus half-sites and an optimal spacer, the AaEcR.AaUSP heterodimer bound an IR with higher affinity than a DR. Co-transfection assays utilizing CV-1 cells demonstrated that the mosquito EcR.USP heterodimer is capable of transactivating reporter constructs containing either IR-1 or DR-4. The levels of transactivation are correlated with the respective binding affinities of the response elements (IRper-1 > DR-4 > IRhsp-1). Taken together, these analyses predict broad variability in the EcREs of mosquito ecdysone-responsive genes.
Sensory Evaluation Techniques (2006)

From listing the steps involved in a sensory evaluation project to presenting advanced statistical methods, Sensory Evaluation Techniques, Fourth Edition covers all phases of sensory evaluation. Like its bestselling predecessors, this edition continues to detail all sensory tests currently in use, to promote the effective employment of these tests,
Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags (2020)

Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(ii) polypyridine complexes as mass-tags for imaging of integrins αvβ3 in human cancer tissues.
Molecular Aggregates of Mixed Ligand Cobalt(III) Complexes Having One or Two Long Alkyl-Chains (1989)

Abstract Mixed ligand amphiphilic cobalt(III) complexes having one or two long alkyl-chains were prepared. Critical micelle concentration of the complex having one dodecyl group in aqueous solution is extremely low compared with that of the amphiphilic ligand, N-dodecylethylenediamine dihydrochloride.
Response to Drs. Patrick and Drossman (2002)

Department of Gastroenterology, Tenri Hospital, Nara, Japan Reprint requests and correspondence: W G Paterson, BSc, MD, FRCPC, Division of Gastroenterology, Hotel Dieu Hospital, 166 Brock Street, Kingston, ON K7L 5G2, Canada. Received Jun. 19, 2002; accepted Jun. 20, 2002.