gebhart/patrepeval huggingface dataset:
Symmetric Versus Asymmetric Pitching of a Cycloidal Rotor Blade at Ultra-Low Reynolds Numbers (2019)

This paper provides a fundamental understanding of the unsteady aerodynamic phenomena on a cycloidal rotor blade operating with symmetric as well as asymmetric pitching at ultralow Reynolds numbers by using a combination of experimental (force and flowfield measurements) and computational fluid dynamics (CFD) studies. The instantaneous blade fluid dynamic forces on a rotating cycloidal rotor blade were measured, which, along with particle image velocimetry (PIV) based flowfield measurements revealed the key fluid dynamic mechanisms acting on the blade. A two-dimensional CFD analysis of the cycloidal rotor was developed and systematically validated using both force and flowfield measurements. The CFD flow solution and PIV-measured flowfield correlated well, especially in the upper half of the circular blade trajectory, and both showed the formation and shedding of strong dynamic stall or leading-edge vortices at high pitch amplitudes, which is the reason for the stall delay and force enhancement. The dynamic virtual camber induced by the flow curvature decreased the blade lift in the upper half due to negative induced camber; however, the lift increased in the lower half due to positive camber. Therefore, introducing an asymmetry in pitch kinematics with higher pitch in the upper half and lower pitch in the bottom half counteracted this inherent lift asymmetry and improved efficiency through a more uniform lift production.
Neonatal outcome in pregnancy hypotiroidee women (2019)

To evaluate the impact that hypothyroidism may have on the course of pregnancy and on neonatal outcome. This cross-sectional study consisting of 160 pregnant women (60 with hypothyroidism and 100 as control) who had been hospitalized at the Obstetrics and Gynecology of the University of Siena. The obstetric visit, the collection of anamnestic data and serum concentrations of TSH, FT4 and AbTPO were performed for each woman. Stratification of the population into two groups based on the BMI showed that there is an average difference of -0.88 before pregnancy BMI between healthy women and hypothyroid women. Moreover, with regard to the obstetric history, 8.7 times higher risk of abortion was found in hypothyroid women. About the current pregnancy in hypothyroid women, slight fetal growth delay, increased risk of premature rupture of membranes (PROM), and a higher risk of developing hypertension and gestational diabetes had been found. The importance of a more detailed anamnesis should be evaluated with greater attention at the beginning of pregnancy. This, in order to avoid the risks related to a hypothyroidism condition during pregnancy and to establish an early therapeutic treatment appropriate to the metabolic demands of each patient.
ChemInform Abstract: Heterocyclic Syntheses with 1,3‐Dicarboalkoxyallenes: Synthesis and Reaction of Heterocyclic Compounds Having Glutaconic Anhydride Structure in the Molecules. (1985)

Abstract Ausgehend von den Allendicarbonsäureestern (I) werden durch Cycloaddition bzw. durch Michael‐Additionen die Heterocyclen (II)‐(VII) hergestellt, die eine Glutaconsäureester‐Partialstruktur besitzen und in die entsprechenden Anhydride übergeführt werden.
Thin Walled Imprinted Polymer Beads Featuring Both Uniform and Accessible Binding Sites (2012)

A novel approach addressing the classical deficiencies of molecularly imprinted polymers (MIPs), that is, low binding capacity and nonuniform binding sites, is reported. The thin walled beads were produced in two steps by first grafting thin MIP films, under controlled (RAFT) or noncontrolled conditions, from porous silica beads following previously reported procedures. The resulting composites were compared in terms of film thickness, the grafted layer homogeneity, the effect of different support morphologies, and for their ability to recognize the template in chromatographic or static binding tests. Thus, using l-Phenylalanine anilide (L-PA) as template to imprint poly(MAA-co-EDMA) in such a way led to nanometer thick films where the resulting composite were able to selectively retain the template in relation to the thickness of the grafted film. In the second step, removing the silica supports from the above composites by etching, led to nanometer thin walled beads with structure, morphology and recognition properties strongly depending on grafting chemistry (RAFT or non-RAFT), monomer dilution and on the film thickness of the original composite. Thus whereas the thicker walled materials retained their mesoporous morphology and displayed enhanced enantioselectivity, load capacity, and higher surface areas compared to their composite precursors, the thin walled beads showed lower surface areas indicating network collapse. The thin walled beads prepared under dilute conditions in absence of RAFT displayed a perfectly uniform binding site distribution and a saturation capacity exceeding that of a conventional monolithic MIP. The beads prepared by RAFT control showed a further enhanced saturation capacity significantly exceeding that of the reference material. Finally, the reduced hydrophobic character of the thin walled materials indicated the existence of two separate pore systems with different pore wettabilities.
Pyridine and pyrimidine ring syntheses from 4‐(4‐morpholino)‐3‐pentenone and from ethyl 3‐(4‐morpholino)‐2‐butenoate (1993)

Abstract 3‐Substituted 2(1 H )‐pyridones are produced from reaction of 4‐(4‐morpholino)‐3‐pentenone 1 with each of the following carbon acids: cyanoacetamide, malononitrile, cyanothioacetamide, acetylacetamide, benzoyl‐acetonitrile. Reaction of ethyl 3‐(4‐morpholino)‐2‐butenoate 2 with cyanoacetamide gives the corresponding hydroxypyridone. Pyrimidines are formed by reaction of 1 and of 2 with benzamidine and with S‐benzylthio‐urea; in the last case, the eliminated morpholine displaces the benzylthio group to give the final product.
ChemInform Abstract: Gold Chemistry Guided by the Isolobality Concept (2012)

Abstract Review: 223 refs.
Using fuzzy logic for diagnosis of technical condition of power circuit breakers (2014)

Monitoring and diagnosis of power circuit breakers represent an important activity for increase the reliability and safety in power system. In order to deal with the uncertain information in the process of diagnosis, the paper presents a diagnosis system based on fuzzy logic which has the role to acquire information about the monitored equipment for faults detection. Also, the paper describe the LabVIEW software application based on fuzzy logic used for diagnosis of power circuit breakers which enable to generate alarms when something it is wrong with the electrical equipment.
Supplementary S3 from Combined Targeting of PARG and Wee1 Causes Decreased Cell Survival and DNA Damage in an S-Phase–Dependent Manner (2023)

&lt;p&gt;Figure S3 shows IHC staining and quantification of Ki67 and phospho-h2ax&lt;/p&gt;
Galileo : une boussole spatiale européenne réglée par des ingénieurs belges (2009)

The 15th Conference on Retroviruses and Opportunistic Infections maintained its place as the premier meeting for presentation of the state of the art of antiretroviral therapy. This year brought together data on new antiretroviral agents in the pipeline, updated our knowledge base of agents approved in the past year (eg, maraviroc, raltegravir, etravirine), delineated approaches to management of treatment-naive and -experienced patients and the use of drugs for prevention of maternal-to-child transmission, and refined our expanding knowledge of drug resistance. A particular highlight of this year's conference was the progress made in antiretroviral treatment and research in resource-limited settings as reflected in both the number and quality of presentations emanating from the developing world.
Stress and stress management among owner‐managers of small and medium‐sized enterprises (1995)

The “stress management industry” has developed whereby organizations and individuals offer stress management interventions. These interventions claim to address a problem, about which there is still a great deal of uncertainty. Most of the literature about stress and its management has been derived from, and thus limited to, large organizations. Explores the issue of stress management as it is experienced by owner‐managers of small and medium‐sized businesses in the UK. Looks at some of the more recent theoretical and empirical literature and concludes with recommendations for stress management within the small firms sector.
Non-Adiabatic Compressor Efficiency of Turbocharger: A Statistical Approach (2010)

The heat transfer occurring within a turbocharger is closely coupled to the internal combustion exhaust. This process is highly complex and it is not taken account either in the choice of components nor is it reflected in the efficiency maps. In particular the flow within the compressor is usually treated as adiabatic. This is not the case since the heat fluxes from both the turbine and the engine must be taken into account in the compression process. Tests at Imperial College enabled the heat fluxes on a turbocharger installed on a 2.0 litre diesel engine to be quantified. The main aim was to evaluate the heat transfer impact on the compressor efficiency. In addition to this a simplified 1-D model was then developed and validated with experimental measurements. Based on the data generated by the model, a correlation for the compressor non-adiabatic efficiency is presented in the paper. A multiple regression procedure was developed; the work is based on a statistical description of the different parameters that affect the heat transfer model. The regression analysis showed that the compressor non-adiabatic efficiency can be evaluated with good degree of confidence by three main independent parameters: Mach number, pressure ratio and “temperature parameter”. The Mach number had the largest effect on the compressor efficiency, while the temperature factor was revealed to be significant only at low speeds. The impact of the turbocharger size on efficiency was also assessed. The length of the bearing housing and the compressor diameter turned out to be significant within a few percentage points of the compressor efficiency.
Tout ce que vous avez toujours voulu savoir sur les stents (sans jamais oser le demander à un expert) (2010)

Auteur(s) : Marc Barthet Departement de Gastroenterologie, Hopital Nord, chemin des Bourrely, 13915 Marseille cedex 20, France Les indications de pose de protheses digestives s'etendent progressivement aux affections benignes. Quelles sont les meilleures indications ? Existe-t-il des protheses dediees a ces indications ? Les indications benignes des protheses digestives ont ete abordees dans la publication de Ott et al. en 2007. Cette [...]
CRISPR: a new principle of genome engineering linked to conceptual shifts in evolutionary biology (2019)

The CRISPR-Cas systems of bacterial and archaeal adaptive immunity have become a household name among biologists and even the general public thanks to the unprecedented success of the new generation of genome editing tools utilizing Cas proteins. However, the fundamental biological features of CRISPR-Cas are of no lesser interest and have major impacts on our understanding of the evolution of antivirus defense, host-parasite coevolution, self versus non-self discrimination and mechanisms of adaptation. CRISPR-Cas systems present the best known case in point for Lamarckian evolution, i.e. generation of heritable, adaptive genomic changes in response to encounters with external factors, in this case, foreign nucleic acids. CRISPR-Cas systems employ multiple mechanisms of self versus non-self discrimination but, as is the case with immune systems in general, are nevertheless costly because autoimmunity cannot be eliminated completely. In addition to the autoimmunity, the fitness cost of CRISPR-Cas systems appears to be determined by their inhibitory effect on horizontal gene transfer, curtailing evolutionary innovation. Hence the dynamic evolution of CRISPR-Cas loci that are frequently lost and (re)acquired by archaea and bacteria. Another fundamental biological feature of CRISPR-Cas is its intimate connection with programmed cell death and dormancy induction in microbes. In this and, possibly, other immune systems, active immune response appears to be coupled to a different form of defense, namely, "altruistic" shutdown of cellular functions resulting in protection of neighboring cells. Finally, analysis of the evolutionary connections of Cas proteins reveals multiple contributions of mobile genetic elements (MGE) to the origin of various components of CRISPR-Cas systems, furthermore, different biological systems that function by genome manipulation appear to have evolved convergently from unrelated MGE. The shared features of adaptive defense systems and MGE, namely the ability to recognize and cleave unique sites in genomes, make them ideal candidates for genome editing and engineering tools.
Calculation method to predict postoperative limb length in patients undergoing THA following developmental dysplasia of hips (2019)

The proposed calculation method effectively predicted the postoperative LLD using preoperative parameters. Despite the complexity of the method, it can go a long way towards reducing the occurrence of severe postoperative LLD in DDH-THA.
Analysis of 8q24.21 miRNA Cluster Expression and Copy Number Variation in Gastric Cancer (2019)

<b>Aim:</b> To analyze gene expression and copy number of five miRNAs (<i>miR-1204</i>, <i>miR-1205</i>, <i>miR-1206</i>, <i>miR-1207</i> and <i>miR-1208</i>) localized in this chromosome region in gastric cancer (GC). <b>Materials & methods:</b> 65 paired neoplastic and non-neoplastic specimens collected from GC patients and 20 non-neoplastic gastric tissues from cancer-free individuals were included in this study. The expression levels of the five miRNAs were accessed by real time qPCR and were correlated. <b>Results:</b> <i>MiR-1207-3p</i>, <i>miR-1205</i>, <i>miR-1207-5p</i> and <i>miR-1208</i> were upregulated in approximately 50% of GC tumors in relation to those of adjacent non-neoplastic tissues. <i>MiR-1205</i> expression was associated with gain of gene copies and was upregulated in adjacent non-neoplastic samples relative to external controls. <b>Conclusion:</b> The coexpression of the 8q24 miRNAs indicated the role of <i>miR-1205</i> in the initiation of gastric cancer development.
Interpretable Network Propagation with Application to Expanding the Repertoire of Human Proteins that Interact with SARS-CoV-2 (2020)

Background: Network propagation has been widely used for nearly 20 years to predict gene functions and phenotypes. Despite the popularity of this approach, little attention has been paid to the question of provenance tracing in this context, e.g., determining how much any experimental observation in the input contributes to the score of every prediction. Results: We design a network propagation framework with two novel components and apply it to predict human proteins that directly or indirectly interact with SARS-CoV-2 proteins. First, we trace the provenance of each prediction to its experimentally validated sources, which in our case are human proteins experimentally determined to interact with viral proteins. Second, we design a technique that helps to reduce the manual adjustment of parameters by users. We find that for every top-ranking prediction, the highest contribution to its score arises from a direct neighbor in a human protein-protein interaction network. We further analyze these results to develop functional insights on SARS-CoV-2 that expand on known biology such as the connection between endoplasmic reticulum stress, HSPA5, and anti-clotting agents. Conclusions: We examine how our provenance tracing method can be generalized to a broad class of network-based algorithms. We provide a useful resource for the SARS-CoV-2 community that implicates many previously undocumented proteins with putative functional relationships to viral infection. This resource includes potential drugs that can be opportunistically repositioned to target these proteins. We also discuss how our overall framework can be extended to other, newly-emerging viruses.
Link Quality Prediction in Mobile Ad-Hoc Networks (2012)

Cognitive radio is the radio revolution of our time. With it comes the promise of huge swathes of unused bandwidth which will provide the fuel for sophisticated wireless applications and fast and reliable wireless internet use. It is as yet unclear precisely what form cognitive networks will take. They may be infrastructure-based, ad-hoc or some combination of the two resulting from a trade-off between technological ideals and economic imperatives. With regard to ad-hoc networks it is clear that they will, at the very least, form an important part of cognitive radio networks for without them co-operative sensing would be considerably less effective. Cooperative sensing is an important tool in guaranteeing non-interference. Indeed in areas or at times where there is no radio infrastructure ad-hoc networks are essential. Communication between ad-hoc nodes is a vexed problem. The propagation environment may be harsh and/or changeable. Furthermore it is very difficult to predict accurately what the signal strength at an intended receiver is. Of course propagation models abound but none can accurately predict signal strength without recourse to topological data and even then these are slow to compute. This is why researchers have focused on path-loss models or statistical methods with which to make their predictions. The following is a literature review of the most prominent methods which have been published over the last fifteen years which will convey for the reader the coalface of research in this area.
Semitransparent metal or distributed Bragg reflector for wide-viewing-angle organic light-emitting-diode microcavities (2000)

Microcavities for organic light-emitting devices (OLED’s) with a metal mirror on one side and a distributed Bragg reflector (DBR) on the other side have been extensively studied in the literature. Usually the DBR is highly reflective, and the resulting emission of the microcavity depends strongly on angle and wavelength. With a thick metal mirror on one side and a semi-transparent metal mirror on the other side of the OLED, a microcavity can be obtained with an optical thickness of 1 half-wavelength. Because the emission is enhanced over a wide solid angle, with a small spectral dependence, this structure is very promising for display applications. For a TPD/ALq3 structure with a typical intrinsic emission spectrum, embedded in a microcavity with a thick and a semitransparent silver mirror, the integrated emission in air, the color variation with angle, and the change in the decay time are compared with those in a DBR-based microcavity.
CFD Analysis of A Twin Screw Compressor with Oil Injection (2021)

In this paper, a full 3D transient Computational Fluid Dynamics (CFD) model of a twin screw compressor with oil injection is described in detail. Volume of Fluid (VOF) two phase flow model is used for gas and liquid phases. The rotor meshes are generated by SCORGTM grid generator and read into the CFD solver at each time step. The simulation runs efficiently and results are obtained in about 12 hours on 24 CPU cores. The CFD prediction of air mass flow rate and indicated power has a good agreement with the experimental data measured at City University of London. The compression pocket is tracked using a customized postprocessing technique and the pressurevolume diagram within it is also obtained and analyzed. Simulations demonstrate that the approaches used in this paper are robust and fast, and can be readily applied to industrial compressor systems for rapid design iterations and improvements.
Influence of expectation and arousal on center-of-pressure responses to transient postural perturbations. (1993)

Central modulation of postural responses to external perturbations appears to be a function of subject expectation, which in turn depends on: 1) prior experience within the testing paradigm, and 2) available information specific to the impending perturbation. Conceivably, the effects of expectation could be mediated, in part, through arousal-related mechanisms. This study investigated the influence of expectation of "postural threat" on center-of-pressure responses to transient translational platform perturbations in 23 healthy young males. The influence of prior experience was assessed first by performing a series of repeated trials using moderately large perturbations. The effect of providing specific prior information was then evaluated by administering small "low-threat" and large "high-threat" perturbations, with and without prior precued information about the perturbation magnitude. Also assessed were the associations between the postural responses and changes in arousal, the latter indicated by heart rate and skin conductance measures. The results showed that prior testing experience had a profound influence on postural strategy selection and execution, whereas the influence of precued prior information was rather more subtle. A tendency to lean forward prior to perturbation was influenced both by experience and prior information. Marked decreases in arousal occurred over the course of the earliest trials, and there was also some evidence that prior information affected arousal. Although causal relationships cannot be established, the results did show evidence of association between arousal and postural responses, suggesting that arousal could have affected postural strategy selection and execution.
IC‐P‐018: DECOUPLING APP EXPRESSION FROM PLAQUE: EFFECTS OF OVEREXPRESSION OF APPSWIND, PRESENCE OF PLAQUE, AND ROLE OF HERPES VIRUS (2019)

One of the biological roles of amyloid precursor protein (APP), precursor to Abeta plaques, is to attach cargo to motors for axonal transport along microtubules. We identified a 15-aa domain in APP that is sufficient to attach kinesin-1 to fluorescent nano-beads. We also reported that transport is decreased in mice when the APP gene is knocked-out. In old transgenic mice expressing human APPSwInd, linked to Familial Alzheimer's Disease (FAD), which displays both over-expression of mutated APP and Abeta plaques, axonal transport is altered, as detected by time-lapse manganese-enhanced magnetic resonance imaging (MEMRI) in living mouse brains. Herpes simplex virus (HSV), a predicted risk factor for AD, interacts with the APP-transport system during infectious particle egress, suggesting a possible link between HSV and AD is mediated by dysfunction of the APP transport system. Using the Tet-off system to control APP expression, we decoupled expression of APPSwInd from presence of plaques in three groups of transgenic mice (APPSwInd + plaque, only plaque, and only APPSwInd) by turning APP off with doxycyclin. We measured transport rates using time-lapse MEMRI captured in an 11.7T Bruker scanner before and at successive time points after stereotactic injection of Mn2+ (3-5nL) into CA3 of the hippocampus. Images of multiple individuals were aligned, and processed, with statistical parametric mapping (SPM) and region of interest intensity analysis. After imaging, brains were harvested for biochemistry or histopathology. We further explored whether HSV suspected of being a risk factor for AD, altered APP expression in the human brain, by examining 44 post-mortem brains of HSV encephalitis victims in sections stained for HSV and APP. APPSwInd expression increased the rate of distal accumulation of Mn2+, whereas plaque decreased the rate and altered proximal destinations. APPSwInd, expressed 3.2-fold over mouse APP, was suppressed with doxycycline. As previously reported in cell culture, HSV up-regulated APP in infected neurons both in the trigeminal ganglion and in the human brain. Together these results suggest that up-regulation of APP induced by infectious agents such as HSV may lead to altered axonal transport and plaque formation, thereby influencing mental processes. Supported NS062184 and MH096093.