gebhart/patrepeval huggingface dataset:
Skeletal Muscle Deoxygenation After the Onset of Moderate Exercise Suggests Slowed Microvascular Blood Flow Kinetics in Type 2 Diabetes (2007)

Type 2 diabetic skeletal muscle demonstrates a transient imbalance of muscle O2 delivery relative to O2 uptake after onset of exercise, suggesting a slowed Qm increase in type 2 diabetic muscle. Impaired vasodilatation due to vascular dysfunction in type 2 diabetes during exercise may contribute to this observation. Further study of the mechanisms leading to impaired muscle oxygen delivery may help explain the abnormal exercise responses in type 2 diabetes.
Integrating Expert Knowledge and Experience (2010)

A major challenge in the field of AI is combining symbolic and statistical techniques. My dissertation work aims to bridge this gap in the domain of real-time strategy games.
Edge Extraction for Polarimetric SAR Images Using Degenerate Filter With Weighted Maximum Likelihood Estimation (2014)

The classic region-based filter for edge extraction for polarimetric synthetic aperture radar images is theoretically founded and efficient. However, in practical use, its performance is limited because the assumption of independence and identical distribution is often not met, particularly in heterogeneous areas. In this letter, we present a degenerate filter design integrated with the weighted maximum likelihood estimation to overcome this limitation. The performance of the proposed methodology is presented and analyzed on both simulated and real experimental data sets using visual presentation, as well as numerical evaluation and comparison with the classic method. They both demonstrate the availability and advantage of the proposed method.
Garlic prevents hypoxic pulmonary hypertension in rats (1998)

Hypoxic pulmonary vasoconstriction underlies the development of high-altitude pulmonary edema. Anecdotal observations suggest a beneficial effect of garlic in preventing high-altitude symptoms. To determine whether garlic influences pulmonary vasoconstriction, we assessed the effect of garlic on pulmonary pressures in rats subjected to alveolar hypoxia and on vasoconstriction in isolated pulmonary arterial rings. Garlic gavage (100 mg/kg body wt) for 5 days resulted in complete inhibition of acute hypoxic pulmonary vasoconstriction compared with the control group. No difference in mean arterial pressure or heart rate response to hypoxia was seen between the groups. Garlic solution resulted in a significant dose-dependent vasorelaxation in both endothelium-intact and mechanically endothelium-disrupted pulmonary arterial rings. The administration of NG-nitro-L-arginine methyl ester (a nitric oxide synthase inhibitor) inhibited the vasodilatory effect of garlic by 80%. These studies document that garlic blocks hypoxic pulmonary hypertension in vivo and demonstrate a combination of endothelium-dependent and -independent mechanisms for the effect in pulmonary arterial rings.
Monolithic silicon chip with 10 modulator channels at 25 Gbps and 100-GHz spacing (2011)

We demonstrate a chip containing ten low-chirp silicon modulators, each operating at 25 Gbps, multiplexed by a SiN arrayed-waveguide grating with 100-GHz spacing, showing the potential for 250 Gbps aggregated capacity on a 5×8 mm(2) footprint.
Characterization of Magnaporthe oryzae Chrysovirus 1 Structural Proteins and Their Expression in Saccharomyces cerevisiae (2012)

Magnaporthe oryzae chrysovirus 1 (MoCV1), which is associated with an impaired growth phenotype of its host fungus, harbors four major proteins: P130 (130 kDa), P70 (70 kDa), P65 (65 kDa), and P58 (58 kDa). N-terminal sequence analysis of each protein revealed that P130 was encoded by double-stranded RNA1 (dsRNA1) (open reading frame 1 [ORF1] 1,127 amino acids [aa]), P70 by dsRNA4 (ORF4; 812 aa), and P58 by dsRNA3 (ORF3; 799 aa), although the molecular masses of P58 and P70 were significantly smaller than those deduced for ORF3 and ORF4, respectively. P65 was a degraded form of P70. Full-size proteins of ORF3 (84 kDa) and ORF4 (85 kDa) were produced in Escherichia coli. Antisera against these recombinant proteins detected full-size proteins encoded by ORF3 and ORF4 in mycelia cultured for 9, 15, and 28 days, and the antisera also detected smaller degraded proteins, namely, P58, P70, and P65, in mycelia cultured for 28 days. These full-size proteins and P58 and P70 were also components of viral particles, indicating that MoCV1 particles might have at least two forms during vegetative growth of the host fungus. Expression of the ORF4 protein in Saccharomyces cerevisiae resulted in cytological changes, with a large central vacuole associated with these growth defects. MoCV1 has five dsRNA segments, as do two Fusarium graminearum viruses (FgV-ch9 and FgV2), and forms a separate clade with FgV-ch9, FgV2, Aspergillus mycovirus 1816 (AsV1816), and Agaricus bisporus virus 1 (AbV1) in the Chrysoviridae family on the basis of their RdRp protein sequences.
Aggresome Formation and Neurodegenerative Diseases: Therapeutic Implications (2008)

Accumulation of misfolded proteins in proteinaceous inclusions is a prominent pathological feature common to many age-related neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis. In cultured cells, when the production of misfolded proteins exceeds the capacity of the chaperone refolding system and the ubiquitin-proteasome degradation pathway, misfolded proteins are actively transported to a cytoplasmic juxtanuclear structure called an aggresome. Aggresome formation is recognized as a cytoprotective response serving to sequester potentially toxic misfolded proteins and facilitate their clearance by autophagy. Recent evidence indicates that aggresome formation is mediated by dynein/dynactin-mediated microtubule-based transport of misfolded proteins to the centrosome and involves several regulators, including histone deacetylase 6, E3 ubiquitin-protein ligase parkin, deubiquitinating enzyme ataxin-3, and ubiquilin-1. Characterization of the molecular mechanisms underlying aggresome formation and its regulation has begun to provide promising therapeutic targets that may be relevant to neurodegenerative diseases. In this review, we provide an overview of the molecular machinery controlling aggresome formation and discuss potential useful compounds and intervention strategies for preventing or reducing the cytotoxicity of misfolded and aggregated proteins.
A dynamic Black-blood Scheme for Myocardial T2 Estimation in Thalassemia (2003)

• Introduction • Recent studies have shown cardiovascular magnetic resonance (CMR) can provide a non-invasive procedure for assessing the iron content of the myocardium, which is useful for early diagnosis and treatment (1, 2, 3). Previously, a T2* technique has been developed and clinically validated for this (1, 2). Conventional T2 measurement techniques have also been attempted but have not found widespread use because of lack of sensitivity, motion artifacts and poor signal-to-noise ratios (SNR) (1). The aim of this study was accordingly a) to develop and improve T2 measurement method for better quantification of myocardial iron concentration, b) to compare the results with a clinically validated T2* technique. For this purpose, a breath-hold multiecho FSE sequence (BH-FSE) was developed. It permits acquisition of multiecho images in one breath-hold, but with relatively low resolution images. This sequence used a new flexible black-blood scheme to cancel blood signal, where real time RR intervals are acquired during scan for realtime inversion recovery time calculation in order to suppress the artifacts due to heart beat variations. Additionally, a non-selective refocusing train was adopted to suppress motion artefacts and to minimize stimulated echoes.
Progress in expanded newborn screening for metabolic conditions by LC‐MS/MS in Tuscany: Update on methods to reduce false tests (2008)

We report on our 6-year experience of expanded newborn screening by tandem mass spectrometry in Tuscany (Italy), the first Italian Region to screen all newborns for more than 40 inborn errors of metabolism: organization, diseases observed and updates on methods to reduce false-positive and false-negative tests are described. Blood collection is recommended between 48 and 72 h of life. Blood spots are sent daily by courier to laboratory. When a positive result occurs, two subsequent procedures are followed: for disorders with possible acute metabolic decompensation, the baby is immediately recalled and clinical examinations and confirmatory tests are performed; for the other disorders, the nursery provides for a second blood spot. If the test is positive, clinical examinations and confirmatory tests are performed. In both cases, if confirmatory tests are positive, a treatment and a follow-up programme are started. Up to now, spots from 160 000 infants have been analysed and 80 affected patients have been identified (disorders of amino acids, organic acids and fatty acids metabolism). We describe adjustments to cut-off values, the introduction of a second-tier test for propionic acidaemia and for methylmalonic aciduria, the inclusion of succinylacetone in the panel of metabolites, and protocols for premature infants and for newborns on parenteral nutrition or transfused. These changes resulted in a reduction in recalls from 1.37% to 0.32% and consequently of working time and parental stress. Avoiding false-negatives by using more specific markers and minimizing the false-positive rate with second-tier testing is important for a successful newborn screening programme.
Robust Surface Reconstruction from Gradient Field Using the L1 Norm (2007)

In this paper, we propose a robust surface reconstruction algorithm from the gradient field by minimizing the absolute error between the input and estimated gradient field from the reconstructed surface. The resulting L1 norm based cost function can then be efficiently solved via linear programming. Compared to conventional L2 estimation algorithms, the proposed approach is more robust to noise corruption and the influence of outliers, while still maintaining low computational cost and global optimality. Moreover, by using the results obtained by our algorithm as initializations for robust M-estimator based cost function, we can obtain much better estimates of surface depth than those initialized by the LS method. Experimental results evidence clear improvements of our proposed approach over the alternatives for the purpose of surface reconstruction.
A 3D reconstruction from real-time stereoscopic images using GPU (2013)

IEEE Xplore Compliant Files 979-10-92279-01-6
Automated correlation and classification of secondary ion mass spectrometry images using a k-means cluster method (2012)

We present a novel method for correlating and classifying ion-specific time-of-flight secondary ion mass spectrometry (ToF-SIMS) images within a multispectral dataset by grouping images with similar pixel intensity distributions. Binary centroid images are created by employing a k-means-based custom algorithm. Centroid images are compared to grayscale SIMS images using a newly developed correlation method that assigns the SIMS images to classes that have similar spatial (rather than spectral) patterns. Image features of both large and small spatial extent are identified without the need for image pre-processing, such as normalization or fixed-range mass-binning. A subsequent classification step tracks the class assignment of SIMS images over multiple iterations of increasing n classes per iteration, providing information about groups of images that have similar chemistry. Details are discussed while presenting data acquired with ToF-SIMS on a model sample of laser-printed inks. This approach can lead to the identification of distinct ion-specific chemistries for mass spectral imaging by ToF-SIMS, as well as matrix-assisted laser desorption ionization (MALDI), and desorption electrospray ionization (DESI).
Satisfaction With and Confidence in Needle‐Free Subcutaneous Sumatriptan in Patients Currently Treated with Triptans (2011)

Patients currently treated with triptans and less than very satisfied with their acute migraine therapy experienced a statistically significant and clinically relevant increase in satisfaction with therapy and enhanced confidence in treatment after use of Sumavel DosePro for up to 4 migraine attacks.
Abstract 4033: Structural Integrity of the Corticospinal Tract Correlated with the Degree of Hand Recovery in Pediatric Patients Following Stroke (2012)

Introduction: The objective was to investigate association of the corticospinal tract (CST) and the association with neurological outcome using Diffusion Tensor Imaging (DTI) to measure the structural integrity of the CST at the level of the cerebral peduncles and the descending CST (DCST) using a tractography based approach (Diffusion Tensor Tractography - DTT) in children with a range of recovery in hand function following arterial ischemic stroke. Methods: Structural integrity of the CST supplying the hand (DTI) and neurological outcome was evaluated in 11 patients and 8 controls. DTI: sequences were performed with 2 dimensional DW EPI, 25 directions, 1000 0b value, TR 8300 msec, TE ∼ 79msc, scan time: 5 minutes. CST integrity at the level of the peduncles was measured by drawing a region-of-interest (ROI) on the anterior cerebral peduncles (Kirton, 2007) and calculating Fractional Anisotropy ([FA], range 0=isotropic, 1=anisotropic) (FSL v4.1). Tract-based spatial statistics (TBSS) were used for CST reconstruction by drawing an ROI on single axial T1-weighted image in which the hand knob region was most noticeable as the initial seed point, and the second ROI on the single axial T1 weighted image in which the cerebral peduncle was most prominent. T-tests with Welch correction (for unequal variance) were used to compare the difference in the mean FA values of the ROIs between peduncles and the DCST in normal controls, and the stroke and non-stroke affected peduncles in patients. The correlation of the mean FA of the DCST and neurological outcome assessed with the sensori-motor subscale of the Pediatric Stroke Outcome Measure. Results: Patients and controls did not differ in age at acquisition (mean=9.61 vs 12.29). DTI: The mean FA values of the peduncles between patients and controls were found to differ between hemispheres (p= .006). The mean FA of the stroke affected (ipsilesional) (mean=.3912) peduncles were significantly lower than the non-affected peduncle (contralesional) (mean =.4336, p=.001). DTT: The tract based analyses also showed FA values (mean=.3197) in the stroke affected DCST were significantly lower than the unaffected (contralesional) DCST (mean=.4441). Correlation analysis a revealed a significant negative correlation between motor outcome and mean FA of the stroke affected DCST (P &lt; 0.05) and the unaffected DCST (P &lt; 0.05). Conclusions: Integrity of the fibers in the DCST shows an association with motor outcome of the hand in pediatric stroke patients. Greater damage to the DCST was associated with a greater motor deficit. The results of this study suggest that the level of motor skill recovery achieved in pediatric stroke patients relates to microstructural status of the DCST.
Study of Characteristics of Dry Friction Damping. (1985)

Abstract : This report pertains to the overall problem of estimating damping due to dry friction forces induced at interfaces of vibrating components. The phase of the effort reported here contains the summary of a literature survey and identifies the scope of research needed. The survey clearly indicated the complex processes involved during rubbing of one component relative to another bringing into play a host of parameters. Very limited data, especially of a fundamental nature, appears to be available in regard to dry friction in a vibratory environment. An analytical and corresponding experimental plan is presented and discussed. These plans include(a) considerations of new laws of friction appropriate to vibration analyses and (b) corresponding basic experiments from which a data base can be developed for use in design of structural components. Keywords: Aerodynamic damping.
Analysis of Utilization of Biological Resources Using Text Mining Based on Freshwater Biodiversity Information Platform (2019)

The Nagoya Protocol on access to genetic resources and fair and equitable sharing of benefits arising from their utilization in the convention on biological diversity entered into force on October 12, 2014. Accordingly, attention toward securing the sovereignty and discovering the utilization value of biological resources has been increasing to secure national competitiveness. We are developing a freshwater biodiversity information platform for the systematic conservation and industrialization of freshwater biodiversity in South Korea. The platform comprises an integrated management system of freshwater bioresources for systematic registration and management of freshwater biodiversity information based on databases; a management system of storage for managing freshwater biological specimen; a utilization information system that manages efficacy, experimental method, and activity produced by the Nakdonggang National Institute of Biological Resources and external big data such as literature and patent; and a freshwater bioresources culture collection for preservation, ordering and deposition of biological resources. These systems are connected organically. Text mining, one of the big data technologies, helps to determine the utility of biological resources through comprehensive analysis. We tried to establish utilization foundations by predicting the usability of biological resources through systematic collection, processing, and analyzing external data, such as abstract, in order to support industrialization of national freshwater bioresources. Through text mining, we constructed a literature-based corpus and preprocessed the corpus with lowercase conversion and removal of stop word. Then, a word cloud was created and statistical analysis was performed. As a result, genes and diseases associated with specific biological resources have been identified. In this study, through a comprehensive analysis of species, genes, and disease information using text mining, we were able to determine the utilization value of biological resources. This study will help the freshwater biodiversity researchers by adding a function for utilization analysis in the utilization information system of the platform in the future.
Experimental Determination of Single CdSe Nanowire Absorption Cross Sections through Photothermal Imaging (2010)

Absorption cross sections ((sigma)abs) of single branched CdSe nanowires (NWs) have been measured by photothermal heterodyne imaging (PHI). Specifically, PHI signals from isolated gold nanoparticles (NPs) with known cross sections were compared to those of individual CdSe NWs excited at 532 nm. This allowed us to determine average NW absorption cross sections at 532 nm of (sigma)abs = (3.17 +/- 0.44) x 10(-11) cm2/microm (standard error reported). This agrees well with a theoretical value obtained using a classical electromagnetic analysis ((sigma)abs = 5.00 x 10(-11) cm2/microm) and also with prior ensemble estimates. Furthermore, NWs exhibit significant absorption polarization sensitivities consistent with prior NW excitation polarization anisotropy measurements. This has enabled additional estimates of the absorption cross section parallel ((sigma)abs) and perpendicular ((sigma)abs(perpendicular) to the NW growth axis, as well as the corresponding NW absorption anisotropy ((rho)abs). Resulting values of (sigma)abs = (5.6 +/- 1.1) x 10(-11) cm2/microm, (sigma)abs(perpendicular) = (1.26 +/- 0.21) x 10(-11) cm2/microm, and (rho)abs = 0.63+/- 0.04 (standard errors reported) are again in good agreement with theoretical predictions. These measurements all indicate sizable NW absorption cross sections and ultimately suggest the possibility of future direct single NW absorption studies.
Anti–cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways (2009)

Our findings indicate that anti-CCP antibodies activate the complement system in vitro via the classical and alternative pathways but not via the lectin pathway. These findings are relevant for the design of interventions aimed at inhibition of complement-mediated damage in RA.
STRATEJİK YÖNETİM VE KAMUDA UYGULANAN STRATEJİLER (2003)

Kamu sektöründe personelin becerileri, verimlilik oranları, yatırımın öncelikleri ve modern yönetim teknikleri bakımından ciddi gelişmeler olmaktadır. Kamu sektöründeki bu son değişiklikler, hem özel hem de kamunun diğer bölümlerindeki hızlı gelişimlerin bir yansıması şeklindedir. Bu gelişmeler bağlamında, yönetim süreci ve kararları organizasyonların kısa ve uzun dönem yapılarıyla kararlarının etkilediği için Stratejik yönetim önemli bir fonksiyon icra etmektedir. Bu yöntem kamu sektöründe karar verme ve işlemlerin uygulanmasında vazgeçilemez bir yöntemdir. Bunun yanında stratejik yönetim, politik ve geleceğe yönelik risk ve kararlarda kendi çevresine uygun alınacak kararların oluşturulmasında etkili olmaya çabalar.
ChemInform Abstract: Iridium‐Catalyzed Intramolecular Methoxy C—H Addition to Carbon—Carbon Triple Bonds: Direct Synthesis of 3‐Substituted Benzofurans from o‐Methoxyphenylalkynes. (2016)

Abstract Following a one‐pot intramolecular hydroalkylation double‐bond migration sequence various 1‐methoxy‐2‐(arylethynyl)benzene derivatives are transformed into benzofurans.
Trichilemmal Carcinoma of the Upper Eyelid: A Case Report (2009)

We report a very rare case of trichilemmal carcinoma (TLC) involving the upper eyelid. To the best of our knowledge, this is the first report of trichilemmal carcinoma of the upper eyelid in Korea. A 51-year-old man presented to our hospital complaining of a bloody discharge from his left upper eyelid. He had a soft and lobulated mass on the palpebral conjunctiva. An incisional biopsy revealed trabecular growth of tumor cells with clear cytoplasm, prominent nucleoli, frequent mitoses, and foci of trichilemmal keratinization. Immunohistochemically, the lesion was positive for p53 and negative for CD 34. A diagnosis of TLC was made, and total excision of the mass and reconstruction of the eyelid were performed. Trichilemmal carcinoma is a rare malignant tumor, though it appears to be an indolent neoplasm with no metastatic potential. The treatment of choice for trichilemmal carcinoma of the eyelid is complete excision with tumor-free margins due to the locally invasive nature of the lesion.
Supplementary Table 2 from Mavorixafor, an Orally Bioavailable CXCR4 Antagonist, Increases Immune Cell Infiltration and Inflammatory Status of Tumor Microenvironment in Patients with Melanoma (2023)

&lt;p&gt;Serum cytokine and chemokine changes at the end of the 3-week monotherapy period compared to baseline.&lt;/p&gt;
Software-defined radio implementation of multiple antenna systems using low-density parity-check codes (2005)

This paper presents the implementation of a multiple antenna communication system using low-density parity-check (LDPC) codes on the software-defined radio (SDR) platform developed at EPFL's Mobile Communications Laboratory. After briefly presenting the general structure and the main capabilities of our SR platform, we describe the methods and algorithms used for designing, encoding and decoding the LDPC codes for MIMO (multiple input multiple output) systems. We have implemented MIMO LDPC systems with up to four transmit and four receive antennas and performed on-the-air measurements which show strong agreement with the theory.