gebhart/patrepeval huggingface dataset:
Local Model Reconstruction Attacks in Federated Learning and their Uses (2022)

In this paper, we initiate the study of local model reconstruction attacks for federated learning, where a honest-but-curious adversary eavesdrops the messages exchanged between a targeted client and the server, and then reconstructs the local/personalized model of the victim. The local model reconstruction attack allows the adversary to trigger other classical attacks in a more effective way, since the local model only depends on the client's data and can leak more private information than the global model learned by the server. Additionally, we propose a novel model-based attribute inference attack in federated learning leveraging the local model reconstruction attack. We provide an analytical lower-bound for this attribute inference attack. Empirical results using real world datasets confirm that our local reconstruction attack works well for both regression and classification tasks. Moreover, we benchmark our novel attribute inference attack against the state-of-the-art attacks in federated learning. Our attack results in higher reconstruction accuracy especially when the clients' datasets are heterogeneous. Our work provides a new angle for designing powerful and explainable attacks to effectively quantify the privacy risk in FL.
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. (1990)

A set of cAMP analogs were synthesized that combined exocyclic sulfur substitutions in the equatorial (Rp) or the axial (Sp) position of the cyclophosphate ring with modifications in the adenine base of cAMP. The potency of these compounds to inhibit the binding of [3H]cAMP to sites A and B from type I (rabbit skeletal muscle) and type II (bovine myocardium) cAMP-dependent protein kinase was determined quantitatively. On the average, the Sp isomers had a 5-fold lower affinity for site A and a 30-fold lower affinity for site B of isozyme I than their cyclophosphate homolog. The mean reduction in affinities for the equivalent sites of isozyme II were 20- and 4-fold, respectively. The Rp isomers showed a decrease in affinity of approximately 400-fold and 200-fold for site A and B, respectively, of isozyme I, against 200-fold and 45-fold for site A and B of isozyme II. The Sp substitutions therefore increased the relative preference for site A of isozyme I and site B of isozyme II. The Rp substitution, on the other hand, increased the relative preference for site B of both isozymes. These data show that the Rp and Sp substitutions are tolerated differently by the two intrachain sites of isozymes I and II. They also support the hypothesis that it is the axial, and not the previously proposed equatorial oxygen that contributes the negative charge for the ionic interaction with an invariant arginine in all four binding sites. In addition, they demonstrate that combined modifications in the adenine ring and the cyclic phosphate ring of cAMP can enhance the ability to discriminate between site A and B of one isozyme as well as to discriminate between isozyme I and II. Since Rp analogs of cAMP are known to inhibit activation of cAMP-dependent protein kinases, the findings of the present study have implications for the synthesis of analogs having a very high selectivity for isozyme I or II.
A manifold microchannel heat sink for ultra-high power density liquid-cooled converters (2019)

Increase in heat fluxes as a result of the miniaturization of power electronics demands new thermal management solutions such as liquid cooling, because of its high heat extraction capabilities. This work describes a new silicon-based heat sink that takes advantage of the high heat extraction capability of microchannel liquid-cooling at low power consumption by co-designing the heat sink and the electronics. A simple combination of cleanroom microfabricated silicon and laser-cutting of plastics was employed to make a microchannel heat sink that simultaneously cools down 20 active devices (hotspots) of a power electronic converter. By flowing liquid close to the active devices through narrow microchannels, we show that the power requirements of the pump can be minimized, resulting in a compact cooling system that allows integration with small and energy-efficient micropumps. The manifold microchannel heatsink is demonstrated on a ultra-high power density magnetic-less 10x-step-up DC/DC converter resulting in a smaller volume and higher cooling capability than conventional heat sinks. The converter was tested up to an output power of 1.2 kW, with an overall efficiency of 96%, and an average temperature rise of only 12.6 °C. The converter and heatsink occupy a volume of 260 mL, resulting in a maximum demonstrated power density of 4.62 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , and a potential to reach a power density up to 26.9 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> .
Advanced high-power superluminescent light sources for environmental, chemical, and biological sensing applications (2004)

In this paper we demonstrate high-power GaAs-based and InP-based superluminescent diodes (SLD) with tilted waveguides emitting in 8xx nm and 15xx nm spectral ranges respectively. The analysis of devices with different cavity lengths emphasizes the tradeoff between output power and spectral width. Power levels of about 200 mW for 820 nm SLDs and about 100 mW for 1590 nm SLDs have been demonstrated for longer cavity devices. Spectral modulation was less than 6-7% at 70-80 mW output power for both 8xx and 15xx SLDs. Simple model proposed for evaluation of spectrum modulation for both GaAs and InP devices based on semi-empirical approach is in agreement with experimental observations.
Host Volatile Attractants and Traps for Detection ofTetropium fuscum(F.),Tetropium castaneumL., and Other Longhorned Beetles (Coleoptera: Cerambycidae) (2004)

Cortical and sapwood volatiles were collected in situ from red spruce, Picea rubens (Sarg.), trees infested with Tetropium fuscum (F.), to determine the relative concentrations and enantiomer ratios of monoterpenes emitted. This information was used to create a synthetic "spruce blend" lure that was tested in various trap designs for efcacy in capturing T. fuscum, and Tetropium castaneum L. in eld bioassays conducted on McNabs Island, Nova Scotia, in 2001 and 2002 and in Poland and Switzerland in 2002. Response of other cerambycid species was measured opportunistically. Cross-vane pan traps baited with spruce blend caught signicantly more T. fuscum than unbaited traps or traps baited with racemic -pinene, ethanol, or both. The addition of an ethanol lure to spruce blend baited traps signicantly increased capture of T. fuscum and T. castaneum. There were no signicant differences among trap designs in mean catch of either Tetropium species. Spruce blend was also signicantly attractive to Monochamus urussovii (Fischer) and, when paired with an ethanol lure, was signicantly attractive to Spondylis buprestoides L. Asemum striatum L. was signicantly attracted to racemic -pinene but was not attracted to spruce blend or spruce blend plus ethanol. None of the lures tested were signicantly attractive to Stictoleptura rubra L. or Alosterna tabacicolor (DeGeer).
Crystal Structure and Binding Properties of the CD2 and CD244 (2B4)-binding Protein, CD48 (2006)

The structural analysis of surface proteins belonging to the CD2 subset of the immunoglobulin superfamily has yielded important insights into transient cellular interactions. In mice and rats, CD2 and CD244 (2B4), which are expressed predominantly on T cells and natural killer cells, respectively, bind the same, broadly expressed ligand, CD48. Structures of CD2 and CD244 have been solved previously, and we now present the structure of the receptor-binding domain of rat CD48. The receptor-binding surface of CD48 is unusually flat, as in the case of rat CD2, and shares a high degree of electrostatic complementarity with the equivalent surface of CD2. The relatively simple arrangement of charged residues and this flat topology explain why CD48 cross-reacts with CD2 and CD244 and, in rats, with the CD244-related protein, 2B4R. Comparisons of modeled complexes of CD2 and CD48 with the complex of human CD2 and CD58 are suggestive of there being substantial plasticity in the topology of ligand binding by CD2. Thermodynamic analysis of the native CD48-CD2 interaction indicates that binding is driven by equivalent, weak enthalpic and entropic effects, in contrast to the human CD2-CD58 interaction, for which there is a large entropic barrier. Overall, the structural and biophysical comparisons of the CD2 homologues suggest that the evolutionary diversification of interacting cell surface proteins is rapid and constrained only by the requirement that binding remains weak and specific.
Safety of the Ullorex® Oral Intragastric Balloon for the Treatment of Obesity (2007)

The Ullorex OIB was successfully utilized in this study, with one serious adverse event that was likely influenced by noncompliance. Body weight and food intake data suggest that the Ullorex OIB be tested further as a possible treatment for obesity.
REVERSING THE NUCLEAR ARMS RACE: GEOPOLITICAL BASES FOR PESSIMISM (1984)

Abstract Political geography's contribution to the debate about war and peace should include re-examining traditional geopolitical concepts (e.g. heartlands, buffer zones) which apparently infuse the superpowers' nuclear strategies. The latter contain dangerously mismatching geopolitical perspectives, which beget NATO's "flexible response" vs. total retaliation by the Warsaw Pact and the latter's view of so-called "theater" weapons like Cruise as strategic. The research agenda also needs to consider whether new weapons technology may make traditional geopolitics and current nuclear strategies obsolete. Key Words: geopoliticsheartlandCruiseEuropean theaterflexible responsetheater and strategic weapons
Digital Variance Angiography in Lower-Limb Angiography with Metal Implants (2020)

Level 4, case studies.
In Vivo Study of Blood Glucose Concentration Prediction with Optical Coherence Tomography (2006)

The capability of optical coherence tomography (OCT) to predict blood glucose concentration changes within physiological range was studied in vivo. Accuracy of 2 mM in prediction of blood glucose concentration by OCT has been achieved.
Microbial Characterization of Space Solid Wastes Treated with a Heat Melt Compactor (2012)

The on going purpose of the project efforts was to characterize and determine the fate of microorganisms in space-generated solid wastes before and after processing by candidate solid waste processing. For FY 11, the candidate technology that was assessed was the Heat Melt Compactor (HMC). The scope included five HMC. product disks produced at ARC from either simulated space-generated trash or from actual space trash, Volume F compartment wet waste, returned on STS 130. This project used conventional microbiological methods to detect and enumerate microorganisms in heat melt compaction (HMC) product disks as well as surface swab samples of the HMC hardware before and after operation. In addition, biological indicators were added to the STS trash prior to compaction in order to determine if these spore-forming bacteria could survive the HMC processing conditions, i.e., high temperature (160 C) over a long duration (3 hrs). To ensure that surface dwelling microbes did not contaminate HMC product disk interiors, the disk surfaces were sanitized with 70% alcohol. Microbiological assays were run before and after sanitization and found that sanitization greatly reduced the number of identified isolates but did not totally eliminate them. To characterize the interior of the disks, ten 1.25 cm diameter core samples were aseptically obtained for each disk. These were run through the microbial characterization analyses. Low counts of bacteria, on the order of 5 to 50 per core, were found, indicating that the HMC operating conditions might not be sufficient for waste sterilization. However, the direct counts were 6 to 8 orders of magnitude greater, indicating that the vast majority of microbes present in the wastes were dead or non-cultivable. An additional indication that the HMC was sterilizing the wastes was the results from the added commercial spore test strips to the wastes prior to HMC operation. Nearly all could be recovered from the HMC disks post-operation and all were showed negative growth when run through the manufacturer's protocol, meaning that the 106 or so spores impregnated into the strips were dead. Control test strips, i.e., not exposed to the HMC conditions were all strongly positive. One area of concern is that the identities of isolates from the cultivable counts included several human pathogens, namely Staphylococcus aureus. The project reported here provides microbial characterization support to the Waste Management Systems element of the Life Support and Habitation Systems program.
Has “Greater” Vanished from the Balkan Vocabulary? Fragmentation and Cohesion in Southeastern Europe (2009)

Talk of a “greater” this or that Balkan nation-state has subsided in recent years as the region experienced the creation of ever more minirepublics—a total of eight on the territory of former Yugoslavia. This trend toward fragmentation was initiated by petty nationalists and fostered by the United States and European powers that found it convenient and desirable to dominate and exploit a bunch of fiefdoms. The outside powers reinforced the new system of minirepublics by inviting candidacy in their continental economic organization, the European Union, and their now global security organization, the North Atlantic Treaty Organization. But is “greater” gone forever from the Balkan vocabulary? It might be prudent not to banish the concept. Think of the phrase of the late Willy Brandt spoken in 1989: “Jetzt wächst zusammen was zusammen gehört”—“Now grows together what belongs together.” Applied to the Balkans in coming decades the ethnic Albanians now living in at least five Balkan states and the ethnic Serbs living in five states, as well, are developing growing kinship with their fellow nationals beyond the current frontiers and local allegiances that currently separate them.
Laguerre-Gaussian mode sorter (2019)

Multi-plane light conversion is a method of performing spatial basis transformations using cascaded phase plates separated by Fourier transforms or free-space propagation. In general, the number of phase plates required scales with the dimensionality (total number of modes) in the transformation. This is a practical limitation of the technique as it relates to scaling to large mode counts. Firstly, requiring many planes increases the complexity of the optical system itself making it difficult to implement, but also because even a very small loss per plane will grow exponentially as more and more planes are added, causing a theoretically lossless optical system, to be far from lossless in practice. Spatial basis transformations of particular interest are those which take a set of spatial modes which exist in the same or similar space, and transform them into an array of spatially separated spots. Analogous to the operation performed by a diffraction grating in the wavelength domain, or a polarizing beamsplitting in the polarization domain. Decomposing the Laguerre-Gaussian, Hermite-Gaussian or related bases to an array of spots are examples of this and are relevant to many areas of light propagation in free-space and optical fibre. In this paper we present our work on designing multi-plane light conversion devices capable or operating on large numbers of spatial modes in a scalable fashion.
Model Selection for Anomaly Detection in Wireless Ad Hoc Networks (2007)

Anomaly detection has been actively investigated to enhance the security of wireless ad hoc networks. However, it also presents a difficulty on model determination, such as feature selection and algorithm parameter optimization. In this paper, we address the issue of parameter selection for one-class support vector machine (1-SVM) based anomaly detection. We have investigated the performance of existing approaches, and also proposed a skewness-based outlier generation approach for parameter selection in the 1-SVM based anomaly detection model
Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells (2023)

PLK1 is a protein kinase that regulates mitosis and is both an important oncology drug target and a potential antitarget of drugs for the DNA damage response pathway or anti-infective host kinases. To expand the range of live cell NanoBRET target engagement assays to include PLK1, we developed an energy transfer probe based on the anilino-tetrahydropteridine chemotype found in several selective PLK inhibitors. Probe 11 was used to configure NanoBRET target engagement assays for PLK1, PLK2, and PLK3 and measure the potency of several known PLK inhibitors. In-cell target engagement for PLK1 was in good agreement with the reported cellular potency for the inhibition of cell proliferation. Probe 11 enabled the investigation of the promiscuity of adavosertib, which had been described as a dual PLK1/WEE1 inhibitor in biochemical assays. Live cell target engagement analysis of adavosertib via NanoBRET demonstrated PLK activity at micromolar concentrations but only selective engagement of WEE1 at clinically relevant doses.
Ways to attract the main segments of health tourists from the Bihor county. (2014)

Touristic seasonality influences economic operators in Romania , the Bihor county included, being therefore necessary and important to identify main customer segments of tourism consumers in the county and find ways for the extension of the touristic period to increase profitability.
Early Increases in Soluble Amyloid-β Levels Coincide with Cholinergic Degeneration in 3xTg-AD Mice (2012)

Accumulation of amyloid-β peptides (Aβ) and cholinergic degeneration are hallmarks of Alzheimer's disease (AD). In a triple transgenic mouse model of AD (3xTg-AD), soluble Aβ42 levels were detected in the septum by 2 months of age, reaching their highest levels at 3-6 months and decreasing at 12 months. Deficits in the number of septal cholinergic neurons and the length of hippocampal cholinergic axons were observed starting at 4 months in 3xTg-AD mice. Our results show that septal Aβ and septohippocampal cholinergic pathology in 3xTg-AD mice occur at an early stage of disease.
Reducing agitator energy consumption without sacrificing agitation (1982)

Rising energy costs and their increasing net effect on the cost of a mineral product requires that every aspect of processing-plant operations reduce consumed horsepower without sacrificing the grade of the product. This paper addresses two principles in the design and selection of axial-flow agitator propellers that contribute to significant reductions in required horsepower. The first of these involves the use of good design principles. The swirling wake generated by an agitator propeller induces losses in the pumping action. By designing an agitator of proper twist and shape one can minimize these losses. Depending upon the design chosen for comparison, these losses can be reduced by 30 to 50% without any sacrifice in pumping or without increasing the complexity of the design. The second aspect involves an appropriate selection of the agitator propeller diameter. The required horsepower can be significantly reduced by using a propeller of larger diameter while operating it at a lower revolutions per minute (RPM) with no sacrifice in the pumping. 3 references, 2 figures, 2 tables.
Single-strand conformation polymorphism (SSCP) analysis of the COL3A1 gene detects a mutation that results in the substitution of glycine 1009 to valine and causes severe Ehlers-Danlos syndrome type IV (1994)

A single base mismatch was detected by single-strand conformation polymorphism (SSCP) of the collagen type III gene in a patient with Ehlers-Danlos syndrome type IV. The patient's fibroblasts secreted both normal and slowly migrating type III procollagen molecules. Two-dimensional CNBr peptide mapping suggested that the defect was localised in the CB9 peptide or the C-propeptide region of the alpha 1 (III)-chain. Analysis of a set of restriction-endonuclease-digested fragments of an amplified cDNA sequence encoding CB9, identified a single-strand conformation polymorphism and localized it within a region of 79 bp corresponding to the carboxyl-terminal end of the CB9 peptide of the alpha 1(III)-chain. DNA sequence analysis demonstrated that the patient was heterozygous for a point mutation converting G to T at base pair 3440 of the collagen alpha 1(III) cDNA resulting in the substitution of glycine with valine at amino acid position 1009 of the alpha 1(III)-chain. The mutation in this patient lies within a region of mutations at the carboxyl-terminal end of the type III collagen alpha-helix which all produce a severe "acrogeric" form of EDS IV.
Increased secretion of insulin-like growth factor I into milk of cows treated with recombinantly derived bovine growth hormone (1989)

Six lactating, non-pregnant Jersey cows were given subcutaneous injections of recombinantly derived bovine growth hormone for 7 d. Milk yield was increased by 4.5 kg/d on d 7, compared with the average yield of 10.7 +/- 0.4 kg/d (mean +/- s.e.m.) for the 7 d preceding treatment. Concentrations of insulin-like growth factor I (IGF-I) in the milk increased from 0.44 +/- 0.04 nmol/l (mean +/- s.e.m.) during the 7 d preceding treatment to 1.6 +/- 0.2 nmol/l on d 7 of treatment. Taking the increase in milk yield into account the total increase in the secretion of IGF-I into milk of one udder half was 6-fold. Plasma concentrations of total IGF-I rose from 15.5 +/- 1.3 nmol/l (mean +/- s.e.m.) on the day preceding treatment to 56.9 +/- 3.6 nmol/l (mean +/- s.e.m.) on d 7 of treatment. Mammary plasma flow increased from 1.6 +/- 0.09 to 2.2 +/- 0.06 l/min.udder half over the same time. Estimates of the amount of IGF-I that reached the mammary gland gave values of 24 and 116 nmol/min.udder half before and during treatment respectively. IGF-I in milk of treated cows was associated predominantly with proteins ranging from 40,000 to 150,000 mol.wt, but a significant proportion (19%) of the total IGF-I was present in the free unbound form. IGF-I crosslinking studies revealed the presence in milk of one specifically labelled band at 31,000 mol.wt.