gebhart/patrepeval huggingface dataset:
Hydroboration of (μ-H)2Os3(CO)10:  Formation of the Borylidyne Cluster (μ-H)2Os3(CO)9(μ-H)2BH. An Improved Synthesis of (μ-H)3Os3(CO)9(μ3-BCO) (1997)

At room temperature, the reaction of (&mgr;-H)(2)Os(3)(CO)(10) with BH(3)S(CH(3))(2) produces the new borylidyne cluster (&mgr;-H)(2)Os(3)(CO)(9)(&mgr;-H)(2)BH, a methylidyne cluster analog. At 65 degrees C the previously reported ketenylidene cluster analog (&mgr;-H)(3)Os(3)(CO)(9)(&mgr;(3)-BCO) is formed. The complex (&mgr;-H)(2)Os(3)(CO)(9)(&mgr;-H)(2)BH was characterized by (1)H NMR, (11)B NMR, and infrared spectroscopies as well as mass spectrometry. Its molecular structure was determined from a single-crystal X-ray analysis. The molecule is of approximate C(s)() symmetry. It consists of a tetrahedral Os(3)B core with a terminal B-H bond, two Os-H-B, hydrogen bridge bonds, and three Os(CO)(3) units. A similar structure has been proposed for one of the isomers of a ruthenium analog, (&mgr;-H)(2)Ru(3)(CO)(9)(&mgr;-H)(2)BH, but it differs from the related iron complex (&mgr;-H)Fe(3)(CO)(9)(&mgr;-H)(3)BH which has three Fe-H-B bridge bonds. Crystal data for (&mgr;-H)(2)Os(3)(CO)(9)(&mgr;-H)(2)BH: triclinic space group P&onemacr;, a = 9.501(4) Å, b = 9.525(4) Å, c = 10.070(2) Å, alpha = 87.72(3) beta = 88.32(3) degrees, gamma = 61.45(3) degrees, Z = 2.
X-ray shapes of distant clusters and blue galaxy fractions (1997)

Based on ROSAT PSPC pointed observations, we have determined the aggregate X-ray shapes of 10 distant (z = 0.17-0.54) rich clusters: A2397, A222, A520, A1689, A223B, A1758, A2218, A2111, A2125, and CL0016+16. Four of the clusters have global X-ray ellipticities greater than 0.2, as measured on a scale of diameter 3 h_{50}^{-1} Mpc. These strongly elongated clusters tend to show substantial amounts of substructure, indicating that they are dynamically young systems. Most interestingly, the global X-ray ellipticities of the clusters correlate well with their blue galaxy fractions; the correlation coefficient is 0.75 with a 90% confidence range of 0.44-0.92. This correlation suggests that blue cluster galaxies originate in the process of cluster formation, and that the blue galaxy proportion of a cluster decreases as the intracluster medium relaxes onto equipotential surfaces.
DEXAMETHASONE IN CROUP. A CONTROLLED STUDY (1970)

Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, California
Evidence of multi-hump temporal solitons in passively mode-locked fiber lasers (2004)

We present the first experimental evidence of multihump temporal cavity solitons. Numerical simulation confirmed the existence of such kind of solitons in passively mode-locked fiber lasers.
Foreign Gene Transfer in Termite Cells Using a Recombinant Vesicular Stomatitis Virus (2008)

The Formosan subterranean termite, Coptotermes formosanus Shiraki, and the eastern subterranean termite, Reticulitermes flavipes (Kollar) (Isoptera: Rhinotermitidae), are well known for their destruction of human dwellings and flora in the tropics and subtropics. A method to deliver foreign genes into termite cell cultures would provide a controlled environment to facilitate the study of key regulatory functions at the molecular and cellular level. Here a method for the establishment and cryopreservation of primary embryonic termite cell cultures is described. Evidence is presented of viral-mediated gene transfer in these cells and foreign gene expression using a recombinant vesicular stomatitis virus vector.
Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II (2010)

Motile cilia generate constant fluid flow over epithelial tissue, and thereby influence diverse physiological processes. Such functions of ciliated cells depend on the planar polarity of the cilia and on their basal bodies being oriented in the downstream direction of fluid flow. Recently, another type of basal body planar polarity, characterized by the anterior localization of the basal bodies in individual cells, was reported in the multiciliated ependymal cells that line the surface of brain ventricles. However, little is known about the cellular and molecular mechanisms by which this polarity is established. Here, we report in mice that basal bodies move in the apical cell membrane during differentiation to accumulate in the anterior region of ependymal cells. The planar cell polarity signaling pathway influences basal body orientation, but not their anterior migration, in the neonatal brain. Moreover, we show by pharmacological and genetic studies that non-muscle myosin II is a key regulator of this distribution of basal bodies. This study demonstrates that the orientation and distribution of basal bodies occur by distinct mechanisms.
A 1 GHz quadrature sinusoidal oscillator (2002)

A low-noise integrated 1 GHz quadrature sinusoidal oscillator that uses lossy planar inductors is presented. The oscillation frequency is digitally-controlled over a 200 MHz range centered at 1.1 GHz, and the measured phase noise at a 100 kHz offset from a 1 GHz carrier is -87 dBc/Hz. Power consumption, including that of the 50 /spl Omega/ drivers, is nominally 165 mW from a 5 V supply.
Carbon nanotubes-Nafion composites as Pt-Ru catalyst support for methanol electro-oxidation in acid media (2009)

碳 nanotubes-Nafion (CNTs-Nafion ) composites 被使妊娠的 CNT 在乙醇答案与 Nafion 准备并且由英尺红外描绘了。在 CNTs-Nafion composites 上支持的 Pt-Ru 催化剂被帮助微波的 polyol 过程综合。催化剂的物理、电气化学的性质被 X 光检查描绘衍射(XRD ) ，传播电子显微镜(TEM ) ，公司脱衣 voltammetry，周期的 voltammetry (CV ) 和 chronoamperometry (CA ) 。结果证明在 CNTs-Nafion composites 的 Nafion 加入显著地没在 CNT 表面上改变包含氧的组。与 2 wt% Nafion 在 CNTs-Nafion composites 上支持的 Pt-Ru 催化剂显示出好分散和最好的公司氧化和甲醇电镀物品氧化活动。
Epigenetic modulation of inflammatory T cell responses (2016)

Abstract Pro-inflammatory T helper (Th) 1 and Th17 cell responses drive autoimmune attack of the central nervous system in Multiple Sclerosis (MS), resulting in disability. In contrast, regulatory Th2 and Treg responses are deficient. The reactivation and expansion of inflammatory T cells is linked to increased severity and active MS disease. Thus, therapeutic strategies that modulate this process would be beneficial. Epigenetic modifications such as histone methylation and acetylation provide control over cellular phenotype. The epigenetic modifying enzyme Protein arginine methyltransferase 5 (PRMT5) is the only known enzyme known to catalyze symmetric dimethylation (SDM) on arginine residues of histones. Although PRMT5 has been shown to be up-regulated in several cancers, there is currently no known role for PRMT5 in T cells. We have found that PRMT5 was up-regulated during re-activation of myelin-specific mouse memory T cells and Experimental Autoimmune Encephalomyelitis (EAE), suggesting that PRMT5 may control expansion of pathogenic autoimmune responses. To test this, we developed novel PRMT5-selective inhibitors in collaboration with the Drug Development Institute at OSU. These novel PRMT5 inhibitors preferentially suppressed Th1 over Th2 cell proliferation, an effect that was partially dependent on IL-2 suppression. In addition, we observed similar effects in human memory T cells, suggesting a conserved function of PRMT5 in both human and mouse. Genetic knockdown of PRMT5 with a short hairpin RNA similarly suppressed inflammatory Th1 cell proliferation. Overall, these data support a role for PRMT5 in memory T cell responses and as a promising therapeutic target in autoimmunity.
Flexible Metal Chelate Polymers Through Nonrigid Metal Centers. (1979)

Abstract : Flexible polymers from conjugated organic ligands and nonrigid metal centers have been synthesized and have been evaluated for thermal stability. A tungsten polymer, bis(5,7-dichloro-8-quinolinolato)-5,8-quinoxalinediolato-tungsten(IV) with number average molecular weight near 40,000 to 50,000 Daltons has been synthesized from the quinoxalinedione and a tungsten(II) intermediate. Several other polymers, monomers, and intermediates have also been investigated, where the metals range from molybdenum and tungsten to zirconium and the eight-coordinate centers are all N4O4 ligand donor sets, and with the seven-coordinate intermediate possessing carbon, phosphorus, nitrogen, oxygen, and/or chlorine donors. The molybdenum and tungsten species appear to have energy-transfer potential. (Author)
Use of the fascia sheath coverage and exogenous fibrin clot in the treatment of complex meniscal tears (1991)

In a previous series, complex meniscal tears, including double flap, double longitudinal, and radial tears, there was reported a high failure rate (14 of 58 repairs, 24%) when treated by conventional arthroscopic repair techniques. There was only one tear in the anterior middle one-third of the lateral meniscus in this group. The use of a fascia sheath to cover the repaired area improves healing rates an additional 17% (from 75% to 92%) with these tear classifications, with the exception of radial split tears in the middle one-third of the lateral meniscus. The present repair technique includes rasp abrasion of the parameniscal synovium, peripheral white rim, and tear surface of the handle fragment. The meniscus is sutured with fully diverged sutures. A rectangle of fascia from the distal anterolateral thigh, trimmed to 25 x 35 to 40 mm, is prepared with the double-armed meniscus suture run along opposite sides. One or two "hold-down" sutures are tied to the superior and inferior main sutures. The four hold-down sutures from the corners and the previously placed hold-down sutures are pulled through the capsule with previously placed pull-through sutures to pull the fascia over the meniscal repair. The exogenous blood clot is injected in the tear under the sheath. This preliminary report suggests that improved healing rates can be obtained with most complex tears by meticulous meniscal repair followed by coverage with the fascia sheath and then exogenous clot injection. Repairs of tears in the middle one-third of the lateral meniscus still show a high failure rate.
Successful Superior Thyroid Artery Embolisation Using Microporous Beads (2012)

During placement of a central catheter in the left internal jugular vein, an arterial puncture led to an expanding haematoma at the level of the thyroid gland due to an ongoing bleeding fed by the left superior thyroid artery, which was successfully treated by embolisation using beads. The micro-porous structure of these microspheres offered optimal attrition, rigidity, elasticity and durability. These beads provided a controlled, targeted embolisation with a better ability to select the desired end point through choice of size.
The Composite Data Model: A Unified Approach for Combining and Querying Multiple Data Models (2014)

In this paper, we combine the characteristics of three fundamental data models in order to represent their semantics in a common framework. These fundamental data models include the familiar concepts of modeling (1) object classes (or entities), their properties (attributes) and relationships between them, (2) multidimensional objects and attributes that can be summarized over the dimensions, and (3) hierarchical structures. This model, called the Composite Data Model, facilitates combinations of these three model structures to be represented jointly in a single schema, thus providing more expressive and natural queries over them. The main advantage of the composite data model (CDM), and a composite query language (CQL) over it, is that any combination of the three fundamental models can be represented jointly based on explicit semantics of each of the fundamental data models. This is unlike existing data models that represent each data model individually or obscure the semantics of additional features being modeled. In order to develop a query language over the combined schemas, we introduce a new concept, referred to as anchor, which is an object class that acts as the focus of the query. We provide in the query language path structures relative to the anchor that facilitate data navigation and data manipulation. We develop the syntax and semantics of the proposed language, and illustrate its expressive power through numerous query examples, and comparisons to three other query languages: OQL, SPARQL, and XQuery.
Comparative LC‐MS: A landscape of peaks and valleys (2008)

Quantitative proteomics approaches using stable isotopes are well-known and used in many labs nowadays. More recently, high resolution quantitative approaches are reported that rely on LC-MS quantitation of peptide concentrations by comparing peak intensities between multiple runs obtained by continuous detection in MS mode. Characteristic of these comparative LC-MS procedures is that they do not rely on the use of stable isotopes; therefore the procedure is often referred to as label-free LC-MS. In order to compare at comprehensive scale peak intensity data in multiple LC-MS datasets, dedicated software is required for detection, matching and alignment of peaks. The high accuracy in quantitative determination of peptide abundance provides an impressive level of detail. This approach also requires an experimental set-up where quantitative aspects of protein extraction and reproducible separation conditions need to be well controlled. In this paper we will provide insight in the critical parameters that affect the quality of the results and list an overview of the most recent software packages that are available for this procedure.
SYNTHESIS OF CHLOROCARBONYL KETENES (1975)

(1975). SYNTHESIS OF CHLOROCARBONYL KETENES. Organic Preparations and Procedures International: Vol. 7, No. 4, pp. 155-158.
Review article: rifabutin in the treatment of refractoryHelicobacter pyloriinfection (2011)

Rifabutin-containing rescue therapy constitutes an encouraging strategy after multiple (usually three) previous eradication failures with key antibiotics such as amoxicillin, clarithromycin, metronidazole, tetracycline and levofloxacin.
“RADIOTRANSCRIPTOMICS”: A synergy of imaging and transcriptomics in clinical assessment (2016)

Recent advances in quantitative imaging and "omics" technology have generated a wealth of mineable biological "big data". With the push towards a P4 "predictive, preventive, personalized, and participatory" approach to medicine, researchers began integrating complementary tools to further tune existing diagnostic and therapeutic models. The field of radiogenomics has long pioneered such multidisciplinary investigations in neuroscience and oncology, correlating genotypic and phenotypic signatures to study structural and functional changes in relation to altered molecular behavior. Given the innate dynamic nature of complex disorders and the role of environmental and epigenetic factors in pathogenesis, the transcriptome can further elucidate serial modifications undetected at the genome level. We therefore propose "radiotranscriptomics" as a new member of the P4 medicine initiative, combining transcriptome information, including gene expression and isoform variation, and quantitative image annotations.
Fluorescence Intensity of Liposomes and E. coli Attached to Nanopillar Arrays: Implications for Bacterial Death on Nanostructures (2023)

Bacterial death on nanostructures has sparked great interest because the principle behind this phenomenon completely differs from that of conventional chemical antimicrobial agents. Physical interactions between the bacterial envelope and nanostructures generate forces that deform the cell membrane. Eventually, the cell envelope breaks, causing the cytoplasm to leak out. However, the events occurring between these stages are unclear. In this work, we used liposomes as pseudocells because they are composed of a lipid bilayer, which is similar to a cytoplasmic membrane. We monitored time-dependent changes in the fluorescence intensities of rhodamine 6G (R6G)-containing liposomes and mCherry-expressing Escherichia coli cells after adhering to Au nanostructure arrays (pitch; height; diameter = 500, 300, 283 nm) and compared the variations in the fluorescence intensities of the pseudo and E. coli cells over time. Electrochemical impedance spectroscopy was then performed to monitor the cell and liposome attachment. Ratio of change in Rct before and after the liposome injection was about 1.7, which means that Rct increased drastically due to the attachment of liposome. Similarly, ratio of change in Rct before and after the E. coli injection was about 1.15 due to the attachment of cell. The fluorescence intensity of mCherry quickly decreased after cell adhesion within 25 min, whereas that of R6G did not even at 60 min. This finding means that the liposomes were not broken down despite their mechanical strength being equal to or weaker than that of E. coli. The time constant (T) of the decrease in fluorescence intensity of E. coli was calculated by fitting the data to an exponential function and found to be −0.13 min–1, which is in good agreement with our previous results. But we could not calculate the T of liposomes. The results indicate that the death of bacteria on nanostructures likely involves an autolytic mechanism.
Long term load forecasting with hourly predictions based on long-short-term-memory networks (2018)

The conventional methodology for long term load forecasting is mostly restricted to electricity load data with monthly or annual granularity. This leads to forecasts with very low accuracy. In this paper, a novel method for long term load forecasting with hourly resolution is proposed. The model is fundamentally centered on Recurrent Neural Network consisting of Long-Short-Term-Memory (LSTM-RNN) cells. The long term relations in a time series data of electricity load demand are taken into account using LSTM-RNN and hence results in more accurate forecasts. The proposed model is implemented on real time data of ISO New England electricity market. Precisely, publicly available data of twelve years from 2004 to 2015 have been collected to train and validate the model. Electricity demand predictions have been made for a period of five years from 2011 to 2015 on a rolling basis. The proposed model is found to be highly accurate with a Mean Absolute Percentage Error (MAPE) of 6.54 within a confidence interval of 2.25%. Moreover, the model has a computation time of approximately 30 minutes which is favorable for offline training to forecast electricity load for a period of five years.
Wearable adjunct ozone and antibiotic therapy system for treatment of Gram-negative dermal bacterial infection (2022)

The problematic combination of a rising prevalence of skin and soft tissue infections and the growing rate of life-threatening antibiotic resistant infections presents an urgent, unmet need for the healthcare industry. These evolutionary resistances originate from mutations in the bacterial cell walls which prevent effective diffusion of antibiotics. Gram-negative bacteria are of special consideration due to the natural resistance to many common antibiotics due to the unique bilayer structure of the cell wall. The system developed here provides one solution to this problem through a wearable therapy that delivers and utilizes gaseous ozone as an adjunct therapy with topical antibiotics through a novel dressing with drug-eluting nanofibers (NFs). This technology drastically increases the sensitivity of Gram-negative bacteria to common antibiotics by using oxidative ozone to bypass resistances created by the bacterial cell wall. To enable simple and effective application of adjunct therapy, ozone delivery and topical antibiotics have been integrated into a single application patch. The drug delivery NFs are generated via electrospinning in a fast-dissolve PVA mat without inducing decreasing gas permeability of the dressing. A systematic study found ozone generation at 4 mg/h provided optimal ozone levels for high antimicrobial performance with minimal cytotoxicity. This ozone treatment was used with adjunct therapy delivered by the system in vitro. Results showed complete eradication of Gram-negative bacteria with ozone and antibiotics typically used only for Gram-positive bacteria, which showed the strength of ozone as an enabling adjunct treatment option to sensitize bacteria strains to otherwise ineffective antibiotics. Furthermore, the treatment is shown through biocompatibility testing to exhibit no cytotoxic effect on human fibroblast cells.
JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability (2020)

Our data support a role for JMJD1B in fine-tuning histone supply to maintain genome integrity, opening novel avenues for cancer therapeutics.
A comparative study of structural patterns and luminescent properties of silver-DAFO complexes with carborane- versus “classical”-diphosphanes (2014)

New complexes with the DAFO (4,5-diazafluoren-9-one) ligand of stoichiometry [Ag(DAFO)(P-P)]OTf [P-P = dppe, 1,2-bis(diphenylphosphane)ethane; dppp, 1,3-bis(diphenylphosphane)propane; dppph, ortho-bis(diphenylphosphane)benzene; dppcc, 1,2-bis(diphenylphosphane)-1,2-dicarba-closo-dodecaborane; dipcc, 1,2-bis(diisopropylphosphane)-1,2-dicarba-nido-dodecaborane], [Ag(DAFO)(P-P*)] [P-P* = dppnc, 7,8-bis(diphenylphosphane)-7,8-dicarba-nido-undecaborate(-1); dipnc, 7,8-bis(diisopropylphosphane)-7,8-dicarba-closo-undecaborate(-1)] and [Ag(DAFO)(OTf)L] [L = PPh3; dpccMe, 1-diphenylphosphane-2-methyl-1,2-dicarba-closo-dodecaborane] are reported. The structures of the complexes depend on the skeleton of the diphosphane. Most of these compounds are luminescent and their emissions seem to have originated from IL (DAFO) transitions, modified upon coordination to silver.
Computer simulation of temperature-dependent growth of fractal and compact domains in diluted Ising models (1989)

A version of the two-dimensional site-diluted spin-(1/2 Ising model is proposed as a microscopic interaction model which governs solidification and growth processes controlled by vacancy diffusion. The Ising Hamiltonian describes a solid-fluid phase transition and it permits a thermodynamic temperature to be defined. The dynamics of the model are taken to involve (i) solid-fluid conversion and (ii) diffusion of vacancies in the fluid phase. By means of Monte Carlo computer-simulation techniques the solidification and growth processes following rapid thermal quenches below the transition temperature are studied as functions of temperature, time, and concentration. At zero temperature and high dilution, the growing solid is found to have a fractal morphology and the effective fractal exponent D varies with concentration and ratio of time scales of the two dynamical processes. The mechanism responsible for forming the fractal solid is shown to be a buildup of a locally high vacancy concentration in the active growth zone. The growth-probability measure of the fractals is analyzed in terms of multifractality by calculating the f(\ensuremath{\alpha}) spectrum. It is shown that the basic ideas of relating probability measures of static fractal objects to the growth-probability distribution during formation of the fractal apply to the present model. The f(\ensuremath{\alpha}) spectrum is found to be in the universality class of diffusion-limited aggregation. At finite temperatures, the fractal solid domains become metastable and a crossover to compact equilibrium solidification is observed as a function of both temperature and time. At low temperatures in the metastable fractal growth regime, the time dependence of the particle content of the domains is found to obey the scaling law, N(t)\ensuremath{\sim}${t}^{D/(2d\mathrm{\ensuremath{-}}D\mathrm{\ensuremath{-}}1)}$. At higher temperatures where the growth is stable and leads to compact domains, the time dependence of N(t) can be described by a simple hyperbolic function. The various results of the theoretical model study are related to fractal and compact growth patterns observed in experimental studies of impure lipid monolayer films at air-water interfaces.