gebhart/patrepeval huggingface dataset:
Effect of ingress buffering on self-similarity of optical burst traffic (2003)

Recently, optical burst switching and aggregated optical packet switching have gained significant exposure as possible future mechanisms for routing aggregated IP traffic over all-optical core networks. However, the limited buffering capacity in all-optical networks presents a major challenge, as current IP traffic displays strong self-similar properties. Reducing the burst loss rate of such long-range dependent traffic can be costly requiring a significant increase in either the network bandwidth or the buffer size of optical cross connects. In this paper, we revisit the possibility of using buffers to reduce self-similarity before the traffic is routed onto the all-optical core. The aim of this paper is to increase the understanding of the effect of packet/burst aggregation on the self-similarity measure of the traffic. In particular, we implement a simple burst assembly mechanism with two parameters, the maximum burst length <i>L</i> and the maximum burst delay <i>d</i>, so that incoming traffic is smoothed with a guaranteed delay bound. Unlike previous works, we simulate the burst assembler using more realistic input traffic sources, and analyze the results using both R/S plot and discrete wavelet analysis methods. Our detailed results show that buffering indeed reduces traffic self-similarity (an area of research controversy) when parameters <i>L</i> and <i>d</i> are set appropriately.
Molecular Properties of ECMA 2 and ECMA 3 Antigens Defined by Monoclonal Antibodies against Embryonal Carcinoma Cells1 (1985)

ECMA 2 and ECMA 3 antigens defined by two monoclonal antibodies are preferentially expressed in early embryonic cells of the mouse. The antigens were isolated from F9 embryonal carcinoma cells by detergent solubilization followed by indirect immunoprecipitation. Both antigens were glycoproteins, which, upon extensive pronase digestion, released the high-molecular-weight glycan (embryoglycan). The immunoprecipitation reactions were inhibited by the glycan, indicating that the two antigens were carried by it. Furthermore, binding of anti-ECMA 2 antibody to the glycan was directly demonstrated by a modified Farr's assay. The antigenic determinant of ECMA 2 antigen was found to involve an alpha-galactosyl residue, since alpha-galactosidase from coffee bean, but not other glycosidases, abolished the antigenic activity. Serological experiments indicated that ECMA 2 antigen is different from other alpha-galactosyl antigens, namely blood group B and P1 antigens and an antigen defined by antibodies in the sera of patients with ovarian germ cell tumors.
Dementia after stroke (1992)

We determined the frequency of dementia in a cohort of 251 patients aged greater than or equal to 60 years hospitalized with acute ischemic stroke, based on examinations performed 3 months after stroke onset. Using modified DSM-III-R criteria, we found dementia in 66 patients (26.3%). Diagnostic agreement among raters was excellent (kappa = 0.96). In a control sample of 249 stroke-free subjects recruited from the community and matched by age, we found dementia in eight subjects (3.2%). Using a logistic regression model to estimate the risk of dementia associated with stroke in the combined samples, the odds ratio (OR) for stroke patients compared with control subjects was 9.4 (p less than 0.001). Advancing age and fewer years of education were significant, independent correlates of dementia, with a trend evident for race (non-white versus white). Confining the analysis to subjects residing in the Washington Heights-Inwood community of northern Manhattan, the OR was 10.3 (p less than 0.001) with significant age and race effects. We conclude that ischemic stroke significantly increases the risk of dementia, with independent contributions by age, education, and race.
Water-soluble anionic conjugated polymers for metal ion sensing: Effect of interchain aggregation Part A Polymer chemistry (2009)

Three sulfonato-containing fluorene-based anionic water-soluble conjugated polymers, which are specially designed to link fluorene with alternating moieties such as bipyridine (P1), pyridine (P2), and benzene (P3) have been synthesized via the Pd-catalyzed Sonogashira-coupling reaction, respectively. These polymers had good solubility in water and showed different responses for transition metal ions with different valence in aqueous environments: the fluorescence of bipyridine-containing P1 can be completely quenched by addition of all transition metal ions selected and showed a good selectivity for Ni²⁺; the pyridine-containing P2 had a little response for monovalent and divalent metal ions while showed good quenching with the addition of trivalent metal ions (with a special selectivity for Fe³⁺); P3 had responses only for the trivalent metal ions within the ionic concentration we studied. After investigation of the UV-vis absorption spectra, PL emission spectra, DLS, and fluorescence lifetime of P1-P3 in aqueous solution when adding transition metal ions, we found that the different spectrum responses of these polymers are attributed to the different coordination ability of the units linked with fluorene in the main chain. The energy or electron-transfer reactions were the main reason for fluorescence quenching of P1 and P2. On the other hand, interchain aggregation caused by trivalent metal ions lead to fluorescence quenching for P3 and also caused partly fluorescence quenching of P1 and P2. These results revealed the origin of ionochromic effects of these polymers and suggested the potential application for these polymers as novel chemosensors with higher sensing sensitivity in aqueous environments.
The Viral E8^E2C Repressor Limits Productive Replication of Human Papillomavirus 16 (2013)

Productive replication of human papillomavirus type 16 (HPV16) occurs only in differentiated keratinocyte cells. In addition to the viral E2 activator protein, HPV16 and related HPV types express transcripts coding for an E8^E2C fusion protein, which limits genome replication in undifferentiated keratinocytes. To address E8^E2C's role in productive replication of HPV16, stable keratinocyte cell lines containing wild-type (wt), E8^E2C knockout (E8-), or E8 KWK mutant (mt) genomes, in which conserved E8 residues were inactivated, were established. Copy numbers of E8- and E8 KWK mt genomes and amounts of early and late viral transcripts were greatly increased compared to those for the wt in undifferentiated keratinocytes, suggesting that HPV16 E8^E2C activities are highly dependent upon the E8 part. Upon differentiation in organotypic cultures, E8 mt genomes displayed higher early viral transcript levels, but no changes in cellular differentiation or virus-induced cellular DNA replication in suprabasal cells were observed. E8 mt genomes were amplified to higher copy numbers and showed increased L1 transcripts compared to wt genomes. Furthermore, the number of cells expressing the viral late protein E4 or L1 or amplifying viral genomes was greatly increased in E8 mt cell lines. In wild-type cells, E8^E2C transcript levels did not decrease by differentiation. Our data indicate that the E8^E2C repressor limits viral transcription and replication throughout the complete life cycle of HPV16.
Fast Raman single bacteria identification: toward a routine in-vitro diagnostic (2016)

Timely microbiological results are essential to allow clinicians to optimize the prescribed treatment, ideally at the initial stage of the therapeutic process. Several approaches have been proposed to solve this issue and to provide the microbiological result in a few hours directly from the sample such as molecular biology. However fast and sensitive those methods are not based on single phenotypic information which presents several drawbacks and limitations. Optical methods have the advantage to allow single-cell sensitivity and to probe the phenotype of measured cells. Here we present a process and a prototype that allow automated single-bacteria phenotypic analysis. This prototype is based on the use of Digital In-line Holography techniques combined with a specially designed Raman spectrometer using a dedicated device to capture bacteria. The localization of single-cell is finely determined by using holograms and a proper propagation kernel. Holographic images are also used to analyze bacteria in the sample to sort potential pathogens from flora dwelling species or other biological particles. This accurate localization enables the use of a small confocal volume adapted to the measurement of single-cell. Along with the confocal volume adaptation, we also have modified every components of the spectrometer to optimize single-bacteria Raman measurements. This optimization allowed us to acquire informative single-cell spectra using an integration time of 0.5s only. Identification results obtained with this prototype are presented based on a 65144 Raman spectra database acquired automatically on 48 bacteria strains belonging to 8 species.
Micrometer-resolution in-fiber OCT probe with tunable working distance (2016)

Optical coherence tomography (OCT) is an attractive modality in biomedical imaging systems due to its non-invasive imaging character. Since the image quality of OCT may be limited by the decrease of transverse resolution away from the focus spot, working distance tunable probe can be a strategy to overcome such limitation and maintain high transverse resolution at different imaging depths. In this paper, a miniature, working distance-tunable in-fiber OCT probe is demonstrated. The influences of the graded index fiber (GIF) length as well as the air cavity length on the working distance and the transverse resolution are simulated and discussed. Experimental results prove that the working distance can be tuned freely from 337.31 μm to 22.28 μm, producing the transverse resolution from 13.86 μm to 3.6 μm, which are in good agreement with the simulated results. The application of the probe in an OCT system for imagining a standard USAF resolution target is investigated in detail. The best resolutions for the standard USAF resolution target imaging are 4.9 μm and 6.9 μm in horizontal and vertical direction, respectively.
A facile in vitro platform to study cancer cell dormancy under hypoxic microenvironments using CoCl2 (2018)

These results demonstrate that this CoCl<sub>2</sub>-based model could provide a widely applicable in vitro platform for understanding induction of cancer cell dormancy under hypoxic stress.
IMPROVEMENT OF RELIABILITY FOR MOVING ELECTRODE TYPE ELECTROSTATIC PRECIPITATOR (2006)

A moving electrode type electrostatic precipitator, which is equipped with brushes to remove dust from the moving collecting plate surface, is effective in collecting high resistivity dust. The collecting plate of the moving electrode type electrostatic precipitator is divided into strips, coupled with chains and moved by driving wheels. In Japan, 51 units of the moving electrode type electrostatic precipitator have been manufactured since 1979.
Supplementary Figure S1-S6 from TMEFF2 Deregulation Contributes to Gastric Carcinogenesis and Indicates Poor Survival Outcome (2023)

&lt;p&gt;Supplementary Figure S1. Identification of TMEFF2 as a key regulator in gastric cancer progression and the expression of TMEFF2 decreased in gastric carcinogenesis. Supplementary Figure S2. Gene Set Enrichment Analysis (GSEA) in TMEFF2-higher/lower expression patients. Supplementary Figure S3. The mRNA levels of the top-score tumorigenesis genes were measured in gastric cells after transfection of TMEFF2 overexpression plasmid or siRNA Supplementary Figure S4. Functional impact of TMEFF2 Supplementary Figure S5. Cell proliferation assays were performed in MKN45 cells after overexpression of SHP-1WT/Î”SH2D1/Î”SH2D2/Î”PTPD or these constructs combined with TMEFF2. n = 3, non-parametric Mann-Whitney test. Supplementary Figure S6. Correlation of TMEFF2 and SHP-1 expression in human GC.&lt;/p&gt;
Synthetic, structural, and physical studies of titanium complexes of catechol and 3,5-di-tert-butylcatechol (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic, structural, and physical studies of titanium complexes of catechol and 3,5-di-tert-butylcatecholBrandan A. Borgias, Stephen R. Cooper, Yun Bai Koh, and Kenneth N. RaymondCite this: Inorg. Chem. 1984, 23, 8, 1009–1016Publication Date (Print):April 1, 1984Publication History Published online1 May 2002Published inissue 1 April 1984https://pubs.acs.org/doi/10.1021/ic00176a005https://doi.org/10.1021/ic00176a005research-articleACS PublicationsRequest reuse permissionsArticle Views2097Altmetric-Citations194LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Multipath Diversity through Time Shifted Sampling for Spatially Correlated OFDM-Antenna Array Systems (2008)

An essential condition for diversity reception is that the fading distributions between individual received signals of an antenna array are uncorrelated. In this paper, a new technique to improve the performance of transmission with the correlated Rayleigh-fading signals is proposed. In conventional array systems, individual receivers start sampling the received signals at the same time with the same sampling rate. On the other hand, in the proposed scheme, the received signals are again sampled with the same rate, however the sampling points are shifted in each receiver. Numerical results through computer simulation show that with correlated received signals, by applying the proposed technique the correlation can be reduced to a sufficient level for diversity reception.
Reduction of soluble CD163, substance P, programmed death 1 and inflammatory markers (2015)

Aprepitant was safe and well tolerated. At the dose used in this proof-of-concept phase IB study, aprepitant did not show a significant antiviral activity. Aprepitant-treated patients had decreased numbers of CD4(+) programmed death 1-positive cells and decreased plasma levels of substance P and soluble CD163, suggesting that blockade of the neurokinin 1 receptor pathway has a role in modulating monocyte activation in HIV infection. Prospective studies in virologically-suppressed individuals are warranted to evaluate the immunomodulatory properties of aprepitant. Exposures exceeding those attained in this trial are more likely to elicit clinical benefit.
The first Dutch SDHB founder deletion in paraganglioma – pheochromocytoma patients (2009)

The identical exon 3 deletions and common haplotype in nine patients indicates that this mutation is the first Dutch SDHB founder mutation. The predominantly non-familial presentation of these patients strongly suggests reduced penetrance. In this small series HN-PGL occurs as frequently as pheochromocytoma and extra-adrenal PGL.
ChemInform Abstract: DIE GEWINNUNG VON BENZOL UND TOLUOL AUS INDUSTRIEANLAGEN DURCH KATALYTISCHES REFORMING (1975)

Abstract Die Herstellung von Benzol und Toluol durch katalytisches Reformieren von Naphthenkohlenwasserstoffen wird in verschiedenen Industrieanlagen an den Reforming‐ Katalysatoren AP‐64 und AP‐56 untersucht.
[Long-term renal function after nephrectomy in living related kidney donors]. (1994)

The purpose of this study is to evaluate the long-term renal function of donors after nephrectomy in living related renal transplantation (n = 100). The survival rate of donors was 98% and causes of death in the other 2% were not associated with the donation. Serum creatinine (Scr) and Creatinine clearance (Ccr) deteriorated just after the donation, but gradually improved. The number of donors with proteinuria increased after donation. In Scr and Ccr there was no significant difference between donors with and without proteinuria. In the donors with hypertension (25.3%) mean urine protein was higher than in those without hypertension. There was a correlation between systolic blood pressure and proteinuria. These results strongly suggest that renal function of donors deteriorates once just after the donation, but gradually improves year by year, and that hypertension is strongly associated with renal dysfunction, especially proteinuria, after the donation.
An electronic ballast with wide dimming range, high PF, and low EMI (2001)

The authors describe an electronic ballast design with the capability of low radiated and conducted EMI over a wide dimming range. It overcomes some limitations of traditional electronic ballasts that use frequency variation for dimming control. The proposed design allows soft switching of the ballast from full-power operation down to less than 10% power. Low-cost and low-voltage power metal oxide semiconductor field effect transmitters (MOSFETs) can be used in the proposed dimmable electronic ballast. The design approach is described and implemented successfully in a 2/spl times/36 W fluorescent lamp system.
The Results of Treating Fecal Incontinence with Antegrade Continence Enema (ACE) (2000)

【Fecal incontinence is not rare in children who have been operated upon for anorectal malformation, Hirschsprung's disease, and meningomyelocele. Incontinence can negatively impact on the emotional and social development of these children. Antegrade continence enema (ACE) was utilized in 9 patients with meningomyelocele from January 1998 to June 1999. Cleanliness and post-operative complications were evaluated. Three operative techniques were employed; reversed appendicocecostomy, in situ appendicostomy and neoappendicostomy with cecal flap. All of the patients achieved complete fecal cleanliness. Four patients had post-operative complications; two with stoma leakage, one with abdominal pain on irrigation and one with stoma stenosis. The leakage was minimal and the pain on irrigation improved spontaneously. The stoma stenosis required revision 6th month postoperatively. The ACE has been shown to be safe and highly effective.】
Correlates of serum hepcidin levels and its association with cardiovascular disease in an elderly general population (2015)

In this random sample of the general community, fibrinogen and γ-glutamyltransferase were the most significant hepcidin correlates independent of iron stores, and hepcidin was related to neither atherosclerosis nor cardiovascular disease.
Decrease of the adhesion of Streptococcus suis serotype 2 mutants to embryonic bovine tracheal cells and porcine tracheal rings. (2001)

Streptococcus suis is an important swine pathogen that may be present in the tonsils of pigs that show no signs of illness. Because adhesion to host cells may be important in the carrier state, this study was undertaken to investigate adhesion to host cells by S. suis mutant strains defective in expression of a 39-kDa protein. Mutant strains of S. suis were generated by transposon Tn916 mutagenesis and were tested for adhesion to embryonic bovine tracheal cells and porcine tracheal rings. Compared with the parent strain, there was a significant reduction in adherence of 3 mutant strains to both bovine tracheal cells and porcine tracheal rings.
Time to diagnostic certainty for saddle pulmonary embolism in hospitalized patients (2023)

There is a lack of diagnostic performance measures associated with pulmonary embolism (PE). We aimed to explore the concept of the time to diagnostic certainty, which we defined as the time interval that elapses between first presentation of a patient to a confirmed PE diagnosis with computed tomography pulmonary angiogram (CT PA). This approach could be used to highlight variability in health system diagnostic performance, and to select patient outliers for structured chart review in order to identify underlying contributors to diagnostic error or delay. We performed a retrospective observational study at academic medical centers and associated community-based hospitals in one health system, examining randomly selected adult patients admitted to study sites with a diagnosis of acute saddle PE. One hundred patients were randomly selected from 340 patients discharged with saddle PE. Twenty-four patients were excluded. Among the 76 included patients, time to diagnostic certainty ranged from 1.5 to 310 hours. We found that 73/76 patients were considered to have PE present on admission (CT PA ≤ 48 hours). The proportion of patients with PE present on admission with time to diagnostic certainty of > 6 hours was 26% (19/73). The median (IQR) time to treatment (thrombolytics/anticoagulants) was 3.5 (2.5-5.1) hours among the 73 patients. The proportion of patients with PE present on admission with treatment delays of > 6 hours was 16% (12/73). Three patients acquired PE during hospitalization (CT PA > 48 hours). In this study, we developed and successfully tested the concept of time to diagnostic certainty for saddle PE.
Experimental Escherichia coli ascending pyelonephritis in rats: changes in bacterial properties and the immune response to surface antigens (1982)

Systemic and urinary antibody responses were examined in rats with experimental ascending pyelonephritis caused by Escherichia coli O6K13H1. During 12-month follow-up of the infections, bacterial characteristics of the urinary and renal isolates were followed: O and K antigenicity, sensitivity to the bactericidal effect of normal human serum, capacity to attach to urinary tract epithelial cells, hemolytic activity, biochemical pattern, and virulence. During the long-term infection, the urinary and renal bacterial isolates changed in O and K antigenicity, serum sensitivity, and virulence. The adhesive capacity of the bacterial isolates did not change, possibly explaining the persistence of the bacteria in the urinary tract. The serum anti-O6 antibody levels remained high during the entire 1-year observation period, especially in the rats with renal involvement. Urinary anti-O6 antibodies were also found. The serum and urinary antibodies could have played a role in bringing about the observed changes in bacterial characteristics. Antibodies to lipid A were recorded in 9 of 16 rats with pyelonephritis and renal scarring and in 1 of 9 rats not having pyelonephritis or renal bacterial growth.