gebhart/patrepeval huggingface dataset:
Two Demonstrators and a Simulator for a Sparse, Distributed Memory (1987)

Described are two programs demonstrating different aspects of Kanerva's Sparse, Distributed Memory (SDM). These programs run on Sun 3 workstations, one using color, and have straightforward graphically oriented user interfaces and graphical output. Presented are descriptions of the programs, how to use them, and what they show. Additionally, this paper describes the software simulator behind each program.
Structural and functional studies of the restriction endonuclease BpuJI (2009)

Type II restriction endonucleases recognize specific DNA sequences and cleave DNA at fixed positions within or close to this sequence. BpuJI recognizes the 5’-CCCGT sequence, but in contrast to other enzymes its cleavage site is very variable. This study shows that BpuJI is a dimer in solution and consists of two separate domains. The N-domain binds to the target sequence as a monomer, while the C-domain is responsible for nuclease activity and dimerization. The nuclease activity is repressed in the apo-enzyme and becomes activated upon specific DNA binding by the N-domains. The activated C-domain cleaves DNA near the target site. In addition, it possesses an end-directed nuclease activity and preferentially cuts ~3 nt from the 3’ terminus. This leads to a very complicated pattern of DNA cleavage. Bioinformatics and mutational analysis revealed that the BpuJI C-domain harbours a PD (D/E)XK active site and is structurally related to archaeal Holliday junction resolvases. The crystal structure of the BpuJI N-domain bound to cognate DNA was solved at 1.3 Å resolution. It revealed two winged-helix subdomains, D1 and D2. The recognition of the target sequence is achieved the amino acid residues located on both the HTH motifs and an N-terminal arm. The BpuJI DNA recognition domain is most similar to the nicking endonuclease Nt.BspD6I. The modelling suggests that Nt.BspD6I could share the specificity-determining regions with BpuJI.
Hypoxia-Induced Inhibition of the Response to Nitroxidergic Nerve Stimulation in Canine Cerebral Arteries (1997)

In isolated canine middle cerebral arteries contracted with prostaglandin F2 alpha, transmural electrical stimulation (TES), nicotine, and substance P produced relaxations. Transmural electrical stimulation- and nicotine-induced endothelium-independent responses are mediated by nitric oxide (NO) liberated from perivascular nerve, whereas substance P-induced relaxations are mediated by endothelium-derived NO. These responses were attenuated by replacement of 95% O2 and 5% CO2 gas (about 550 mm Hg of partial O2 pressure) with 95% N2 and 5% CO2 gas (about 40 mm Hg); inhibition of the response to TES was stabilized 30 minutes later. Reoxygenation partially reversed the response. Relaxations caused by exogenous NO were not influenced by hypoxia. Inhibition by hypoxia of the response to TES was not affected by superoxide dismutase. However, the inhibitory effect was prevented by amiloride and dimethyl-amiloride, Na(+)-H+ exchange inhibitors, or acidosis caused by the addition of HCl. The inhibition by hypoxia was reversed by amiloride. It is concluded that depression by hypoxia of the response mediated by endogenous NO is associated with impaired membrane function caused by restoration of normal intracellular pH by Na(+)-H+ exchanger.
Prevalence and Clinical Significance of Sterile Intra-amniotic Inflammation in Patients with Preterm Labor and Intact Membranes (2014)

(i) Sterile intra-amniotic inflammation is more frequent than microbial-associated intra-amniotic inflammation, and (ii) we propose that danger signals participate in sterile intra-amniotic inflammation in the setting of preterm labor.
Dynamic Motor Tests from Synchronously Sampled Waveforms (1986)

A computer-aided motor tester that is very flexible is described. It can be used to test any motor or motor system that operates on ac power. The system was especially designed for testing induction motors and electronically controlled motors. Synchronous waveform data sampling is used instead of meters or instrument converters. Three computers are strategically employed to sample data, control the test, and process the data. For induction motors, the new system has been useful in clarifying the dynamic test. Per-cycle evaluations of data based on instantaneous samples have provided dynamic test data that are both fast and accurate.
Cacao, Shade, and Agroforestry (2021)

In its natural habitat, cacao grows in the shade of larger trees. In fact, 70 percent of the world’s cacao is grown with some level of shade. This comes mostly from native forest trees, thinned out to provide space for cacao seedlings to be planted, or to a lesser extent, from trees specially planted to provide shade. This mixture of shade trees and shrubs creates a three-tier canopy, resulting in a multi-species system similar in structure and function to a forest, known as an agroforest. Cacao agroforestry systems include full-sun cacao, diversified-shade cacao, and specialized-shade cacao. Achieving an appropriate level of shading for cacao is important, since it affects yield and can influence pest and disease outbreaks. Shade in cacao also helps to maintain biodiversity, so getting shade right in cacao agroforestry is important. This chapter examines the benefits and problems associated with growing cacao with and without shade.
Effect of well diameter upon microwell detector performance (2000)

MicroWell (MWD) detectors have been produced by laser micromachining of 125 /spl mu/m thick Kapton/sup TM/ polyimide foil. Wells produced with this technique have near-vertical sidewalls with less than 10/spl deg/ of slope. It is an ideal tool to produce MWD prototype arrays with different well diameters for an experimental determination of the optimum ratio of well diameter to substrate thickness. Arrays with four different well diameters (60, 100, 150, and 180 /spl mu/m) were machined into 125 /spl mu/m thick Kapton/sup TM/ polyimide foil. Detectors with well diameters commensurate with the substrate thickness had better performance, with the best design being an array of 150 /spl mu/m diameter wells on a 200 /spl mu/m Cartesian grid. This design achieved a gas gain of 17,000 in a counting gas of 70% argon and 30% carbon dioxide. Other significant advantages of this design included good charge collection from the drift region and increased gas gain with higher drift fields.
The fecal microbiome in diverticulitis and asymptomatic diverticulosis: A case-control study in the US (2019)

Objective The intestinal microbiota are hypothesized to play a role in the pathogenesis of diverticulitis. We compared fecal microbial communities in individuals with diverticulitis to those with uncomplicated diverticulosis. Methods We used 16S ribosomal RNA gene sequencing to assess and compare the microbiota composition of fecal samples from 10 patients presenting with acute diverticulitis (cases) and 10 controls with asymptomatic diverticulosis matched on age and sex. Results We found differences in the distribution of relative abundances of bacterial phyla and genera in diverticulitis cases versus diverticulosis controls. At the phyla level, Verrucomicrobia was more abundant on average in diverticulitis cases at the time of diagnosis than in diverticulosis controls (p=0.07). Univariate analysis identified a significant increase in the genera Coriobacteria (p=0.050), Anaerotruncus (0.046), Subdoliganulum (p=0.034), Marvinabryantia (p=0.006), and Akkermansia (p=0.04), and a decrease in Barnesiella (p=0.035) and Coprococcus (p=0.035) in diverticulitis cases at the time of diagnosis compared to diverticulosis controls. However, after correction for multiple comparisons, these differences were no longer significant. Partial least squares discriminant analysis on all microbial genera showed partial separation of diverticulitis cases at diagnosis and diverticulosis controls. The microbial alpha diversity was higher in diverticulitis cases at time of diagnosis vs controls but this was not significant (Shannon diversity index 7.4±0.6 vs 6.8±0.7, p=0.08). Conclusions Individuals with diverticulitis differ from those with asymptomatic diverticulosis based on components of the fecal microbiome.
Group 6 Transition‐Metal/Boron Frustrated Lewis Pair Templates Activate N2and Allow its Facile Borylation and Silylation (2017)

Abstract The reaction of trans ‐[M(N 2 ) 2 (dppe) 2 ] (M=Mo, 1 Mo , M=W, 1 W ) with B(C 6 F 5 ) 3 ( 2 ) provides the adducts [(dppe) 2 M=N=N‐B(C 6 F 5 ) 3 ] ( 3 ) which can be regarded as M/B transition‐metal frustrated Lewis pair (TMFLP) templates activating dinitrogen. Easy borylation and silylation of the activated dinitrogen ligands in complexes 3 with a hydroborane and hydrosilane occur by splitting of the B−H and Si−H bonds between the N 2 moiety and the perfluoroaryl borane. This reactivity of 3 is reminiscent of conventional frustrated Lewis pair chemistry and constitutes an unprecedented approach for the functionalization of dinitrogen.
The Autoling System (1968)

The AUTOLING system represents an attempt to replace the human linguist with a machine in the process of linguistic fieldwork with an informant. To the extent that the attempt succeeds, the analytic and heuristic methodology of live linguists can be considered formalized.&#13;\nThe current system consists of three as yet unjained components: a morphological analyzer, a program for learning context-free phrase structure grammar, and a program for learning monolingual and bilingual transformations. All programs are written in ALGOL and operational on the Burroughs B-5500 computer. The capabilities of the system are illustrated with examples of its treatment of selected problems in English, Latin, Roglai, Indonesian, Thai, Chinese and German.
Lock-free garbage collection for multiprocessors (1991)

Article Free Access Share on Lock-free garbage collection for multiprocessors Authors: Maurice P. Herlihy Digital Equipment Corporation, Cambridge Research Laboratory, One Kendall Square, Cambridge, MA Digital Equipment Corporation, Cambridge Research Laboratory, One Kendall Square, Cambridge, MAView Profile , J. E. B. Moss Dept. of Comp. and Info. Sci., University of Massachusetts, Amherst, MA Dept. of Comp. and Info. Sci., University of Massachusetts, Amherst, MAView Profile Authors Info & Claims SPAA '91: Proceedings of the third annual ACM symposium on Parallel algorithms and architecturesJune 1991Pages 229–236https://doi.org/10.1145/113379.113400Published:01 June 1991Publication History 10citation398DownloadsMetricsTotal Citations10Total Downloads398Last 12 Months17Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
A mobile ticket validation by VSS tech with time-stamp (2004)

Mobile commerce is becoming increasingly important in business. We find the e-ticket to be a popular way of implementing m-com. In order to solve some authentication drawback we propose a mobile ticket validation method using VSS (Visual Secret Sharing) technology with a time-stamp protocol on the mobile environment. The VSS encryption technology separates the ticket into two parts; one part of the ticket is sent to the user after purchasing. The other part is sent to the user when the time-stamp is reached. The time-stamp protocol can provide secure and fast verification. In our validation method, we offer lightweight load for a mobile device and simple identification work.
Polymorphism and evolution of influenza A virus genes. (1986)

The nucleotide sequences of four genes of the influenza A virus (nonstructural protein, matrix protein, and a few subtypes of hemagglutinin and neuraminidase) are compiled for a large number of strains isolated from various locations and years, and the evolutionary relationship of the sequences is investigated. It is shown that all of these genes or subtypes are highly polymorphic and that the polymorphic sequences (alleles) are subject to rapid turnover in the population, their average age being much less than that of higher organisms. Phylogenetic analysis suggests that most polymorphic sequences within a subtype or a gene appeared during the last 80 years and that the divergence among the subtypes of hemagglutinin genes might have occurred during the last 300 years. The high degree of polymorphism in this RNA virus is caused by an extremely high rate of mutation, estimated to be 0.01/nucleotide site/year. Despite the high rate of mutation, most influenza virus genes are apparently subject to purifying selection, and the rate of nucleotide substitution is substantially lower than the mutation rate. There is considerable variation in the substitution rate among different genes, and the rate seems to be lower in nonhuman viral strains than in human strains. The difference might be responsible for the so-called freezing effect in some viral strains.
Unique association of hypochondroplasia with craniosynostosis and cleft palate in a Mexican family (2017)

Hypochondroplasia (HCH) is a skeletal dysplasia caused by an abnormal function of the fibroblast growth factor receptor 3. Although believed to be relatively common, its prevalence and phenotype are not well established owing to its clinical, radiological, and genetic heterogeneity. Here we report on a molecularly proven HCH family with an affected father and two children. The siblings (male and female) with HCH also had craniosynostosis and cleft palate, respectively. The present report supports the conclusion that the full clinical spectrum of HCH is not completely delineated. It also suggests that secondary, as yet unknown, modifying factors can influence the final phenotype.
1085. Directed Evolution of AAV2 Leads to Improved Viral Function (2005)

Adeno-associated viral (AAV) vectors are extremely safe and efficient gene delivery vehicles. However, numerous challenges in vector design remain, including neutralizing antibody responses, tissue transport, and infection of resistant cell types. In each case, the AAV capsid structure determines how the vector performs when presented with these barriers. Nature has evolved multiple AAV serotypes using mutagenesis and recombination, indicating a natural level of plasticity in viral structure and function. We have employed analogous techniques to rapidly generate a large random mutant AAV2 library and have selected for mutant AAV virions that display novel phenotypes. Specifically, we have selected the AAV2 library for infectious particles with altered heparin sulfate (HS) affinity and for the ability to evade an AAV2 immune response. Characterization of the mutants with both lower and higher affinity to heparin led to the location of novel point mutations on the capsid structure. Several of these mutations lie inside the capsid while two exposed mutations (K258E and S261F) lie in the canyon region. Furthermore, we have evolved vector variants that have greater than 100-fold improved resistance to serum that neutralizes wild type AAV2, yet retain AAV2 gene delivery efficiency. Analysis of the point mutations revealed one change on the surface of the 3-fold spike (N587I) and another change on the 2-fold dimple region (T716A) were critical to the enhanced resistance. Testing these vectors in animal studies may indicate that they could mediate gene delivery even in patients with pre-existing immunity. Finally, our libraries can be further analyzed to isolate mutants that surpass other barriers to successful gene delivery.
The thermoluminescence response of undoped silica PCF for dosimetry application (2013)

This work concerns the suitability of the undoped silica photonic crystal fibre (PCF) as ionizing radiation dosimeters. The dosimetric capabilities of PCF optical fibres in terms of thermoluminescence (TL) and dose response have been investigated and compared with the single mode fibre (SMF) subjected to 6 MeV electron irradiations. The PCF shows dose response linearity curves in a dose range familiar to conventional radiation therapy covering doses from 1 to 4Gy.
In-flight entertainment-getting from wishlist to reality (1999)

Much of what we see in the consumer electronics stores will eventually find its way into airplanes in the form of In-Flight Entertainment (IFE). This consumer electronic equipment is often referred to as "the leading edge of technology". Unfortunately, that same equipment that is the "leading edge" of consumer electronics, often stalls to feel like the "bleeding edge" when you try to integrate it into IFE systems for today's modern aircraft. Unlike Avionics Systems, the technologies behind IFE equipment are not usually mature before they are integrated into the aircraft. What may work well in a home environment, may not work well at all in the aircraft environment. Often this problem results in last minute redesign in an effort to make the equipment function as intended on the aircraft. Both the FAA and the aircraft manufacturer impose many requirements on the suppliers and products of IFE. Systems need to be designed for the aircraft environment. Many variations on IFE Systems have forced the creation of new standards for integration into commercial aircraft. Power, cooling, and EMC issues are becoming more of a concern as we move to fill aircraft implementations. Beyond the technical evaluations and lab/aircraft testing, one key component is customer satisfaction. This paper will cover some of the methods and tools we use to get IFE from wishlist to reality.
ChemInform Abstract: Bioinspired Supramolecular Catalysis (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery (2019)

An innovative microneedle (MN)-based cell therapy is developed for glucose-responsive regulation of the insulin secretion from exogenous pancreatic β-cells without implantation. One MN patch can quickly reduce the blood-sugar levels (BGLs) of chemically induced type-1 diabetic mice and stabilize BGLs at a reduced level for over 10 h.
Optical resonators with nonuniform magnification (1984)

The geometrical-optics properties of a new class of resonators are derived. The resonator magnification is defined by sequential ray positions at one cavity mirror and is assumed to be a function of the transverse coordinate. This function alone is sufficient to determine the geometrical eigenvalues and mode-intensity functions of the cavity. In the opposite sense, if one mode-intensity function is specified, the required magnification function can. be derived. The eigenvalues depend solely on the value of the magnification at the resonator axis. To determine the geometry of the resonator and of the wave front uniquely, additional information must be specified. Mirror-sag formulas are derived for two cases, the self-correcting resonator and the half-symmetric resonator.
Alternative Synthetic Strategies for Enantioselective Construction of Halogenated Chiral Carbon Centers (2010)

This review focuses on the enantioselective synthesis of halogenated molecules having a chiral halocarbon center. In particular, this review discusses enantioselective transformations with haloalkenes and enantioselective α-substitutions of α-halo carbonyl compounds. Enantioselective halogen-transfer reactions are excluded from this review.
Succinic semialdehyde dehydrogenase. Reactivity of lysyl residues. (1979)

The enzyme succinic semialdehyde dehydrogenase from pig brain has been 2000-fold purified by a combination of DEAE-cellulose, hydroxyapatite, and AMP-Sepharose chromatography. This preparation has a molecular weight of 160,000 and a specific activity of 5.3 mumol/min.mg at 25 degrees C. The inhibition of succinic semialdehyde dehydrogenase by carbonyl compounds, i.e. P-pyridoxal and o-phthalaldehyde was investigated in detail. The enzyme is reversible, inhibited by preincubation with P-pyridoxal (mixing molar ratio, 300:1) at either 25 degrees or 37 degrees C. Reduction with NaBH1 results in the incorporation of approximately 4 mol of P-pyridoxyl residues/mol of enzyme. NAD+ protects the enzyme against inactivation by P-pyridoxal, whereas the substrate succinic semialdehyde failed to prevent the reaction of P-pyridoxal with lysine residues of the protein. The binding of approximately 10 mol of o-phthalaldehyde/mol of enzyme results in irreversible loss of catalytic activity. The reaction is fast and easily monitored by absorption and fluorescence spectroscopy.
Sino/American cooperation for rural electrification in China (1997)

Rapid growth in economic development, coupled with the absence of an electric grid in large areas of the rural countryside, have created a need for new energy sources both in urban centers and rural areas in China. There is a very large need for new sources of energy for rural electrification in China as represented by 120 million people in remote regions who do not have access to an electric grid and by over 300 coastal islands in China that are unelectrified. In heavily populated regions in China where there is an electric grid, there are still severe shortages of electric power and limited access to the grid by village populations. In order to meet energy demands in rural China, renewable energy in the form of solar, wind, and biomass resources are being utilized as a cost effective alternative to grid extension and use of diesel and gasoline generators. An Energy Efficiency and Renewable Energy Protocol Agreement was signed by the U.S. Department of Energy with the Chinese State Science and Technology Commission in Beijing in February, 1995. Under this agreement, projects using photovoltaics for rural electrification are being conducted in Gansu Province in western China and Inner Mongolia in northern China, providing the basis for much wider deployment and use of photovoltaics for meeting the growing rural energy demands of China.