gebhart/patrepeval huggingface dataset:
Interactions between cognition and circadian rhythms: Attentional demands modify circadian entrainment. (2009)

Animals and humans are able to predict and synchronize their daily activity to signals present in their environments. Environmental cues are most often associated with signaling the beginning or the end of a daily activity cycle, but they can also be used to time the presentation or availability of scarce resources. If the signal occurs consistently, animals can begin to anticipate its arrival and ultimately become entrained to its presence. While many stimuli can produce anticipation for a daily event, these events rarely lead to changes in activity patterns during the rest of the circadian cycle. Here the authors demonstrate that performance of a task requiring sustained attention not only produces entrainment, but produces a robust modification in the animals' activity throughout the entire circadian cycle. In particular, normally nocturnal rats, when trained during the light phase (ZT 4) adopted a significant and reversible diurnal activity pattern. Of importance, control experiments demonstrated that this entrainment could not be attributed to the noncognitive components of task performance, such as handling, water deprivation, access to water used as a reward, or animal activity associated with operant training. These findings additionally indicate that levels of cognitive performance are modulated by the circadian cycle and that such activity can act as a highly effective entrainment signal. These results form the basis for future research on the role of neuronal systems mediating interactions between cognitive activity and circadian rhythms.
A review of the JR blood group system (2013)

The JR blood group system (ISBT 032) consists of one antigen,Jra, which is of high prevalence in all populations. The rare Jr(a-) phenotype has been found mostly in Japanese and other Asian populations, but also in people of northern European ancestry, in Bedouin Arabs, and in one Mexican. Anti-Jra has caused transfusion reactions and is involved in hemolytic disease of the fetus and newborn. The Jra antigen is located on ABCG2 transporter, a multipass membrane glycoprotein (also known as the breast cancer resistance protein, BCRP), which is encoded by the ABCG2 gene on chromosome 4q22.1. The Jr(a-) phenotype mostly results from recessive inheritance of ABCG2 null alleles caused by frameshift or nonsense changes.
The Simulation of MOS Integrated Circuits Using SPICE2 (1980)

Abstract : This report is addressed to all SPICE2 users involved in the design of MOS (Metal Oxide Semiconductor) IC's (Integrated circuits). The material contained herein serves as an addition to the SPICE2.G User's Guide. The device and model parameters documented refer to the SPICE2.G release versions from the University of California, Berkeley and obsolete the information contained in the SPICE2 MOS Modeling Handbook which is valid for the SPICE2.D release versions. The impact of MOS IC s in both analog and digital applications as well as the decreasing dimensions of the single transistors enabled by advances in processing have made it necessary to refine the models and to provide more information about each device as it appears on the circuit layout. Associated with each MOSFET is a drain and source-junction sidewall capacitance (which has a different voltage dependence than the bottom of the diffusion) and a parasitic series resistance. These are unique to a certain geometry. At the model level there are effects which become important as the channel length and width go below 10um. A thorough description of all parameters appearing on the element (device) card and model card is contained in Sec. 2. In SPICE2.G there are three different MOS models available to the user. The Level 1 model is the simple Shichman-Hodges model implemented according to Nagel s SPICE2: A Computer Program to Simulate Semiconductor Circuits. This first order model has been found necessary for checking out the correctness of hand calculations when understanding or developing new circuits. The Level 2 model is an analytical one-dimensional model which incorporates most of the second-order effects of small-size devices. The Level 3 model is a semi-empirical model described by a set of parameters which are defined by curve-fitting rather than physical background.
The Road to Implementation of the Electronic Health Record (2006)

"The Road to Implementation of the Electronic Health Record." Baylor University Medical Center Proceedings, 19(4), pp. 311–312
X-ray diffraction order selection with a prism in DEI (abstract) (2002)

The refraction angle of x rays as they pass through a refractive prism is proportional to the square of the x-ray wavelength. This was used to discriminate between different harmonic orders, which have different energies, created by a two-crystal 111 monochromator [Z. Zhong, J. Appl. Crystallogr 33, 1082 (2000)]. Refractive prisms inserted between the two monochromator crystals allowed selection, among the 111, 333, 444, and 555 diffractions, in our diffraction enhanced imaging program at National Synchrotron Light Source’s X15A beamline, and facilitated convenient change of sensitivity in our efforts to optimize DEI system for mammography and other radiographic applications. The selection of 111 and 333 refractions were straightforward since the necessary angle of refraction is small. The challenge of selecting 444 and 555 reflections was met by designing an acrylic prism that offered an angle of refraction much larger than 10 μrad and was compact enough to be manipulated in the small space between the crystals. Examples are given on use of the prism for studying the effects of diffraction orders on DEI’s refraction and extinction contrasts. Its modes of operation and limitations are discussed. The principle of harmonics selection through prism and the specific design of the device could be relevant for other synchrotron monochromators that have a harmonics concern or can benefit from change of energy, through selection of harmonic orders, without changing crystals.
The Influence of the Pituitary Gland on Sodium Conservation, and Plasma Renin and Renin Substrate Concentrations in the Rat (1970)

Conference Abstract| January 01 1970 The Influence of the Pituitary Gland on Sodium Conservation, and Plasma Renin and Renin Substrate Concentrations in the Rat F. J. Goodwin; F. J. Goodwin 1Departments of Medicine, The London Hospital, and Presbyterian Hospital, New York Search for other works by this author on: This Site PubMed Google Scholar J. D. Kirshman; J. D. Kirshman 1Departments of Medicine, The London Hospital, and Presbyterian Hospital, New York Search for other works by this author on: This Site PubMed Google Scholar J. E. Sealey; J. E. Sealey 1Departments of Medicine, The London Hospital, and Presbyterian Hospital, New York Search for other works by this author on: This Site PubMed Google Scholar J. H. Laragh J. H. Laragh 1Departments of Medicine, The London Hospital, and Presbyterian Hospital, New York Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (1970) 38 (1): 2P–3P. https://doi.org/10.1042/cs038002Pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation F. J. Goodwin, J. D. Kirshman, J. E. Sealey, J. H. Laragh; The Influence of the Pituitary Gland on Sodium Conservation, and Plasma Renin and Renin Substrate Concentrations in the Rat. Clin Sci 1 January 1970; 38 (1): 2P–3P. doi: https://doi.org/10.1042/cs038002Pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1970 The Biochemical Society and the Medical Research Society1970 Article PDF first page preview Close Modal You do not currently have access to this content.
Indicadores del uso de competencias informáticas entre estudiantes universitarios. Implicaciones formativas y sociales (2013)

El presente artículo pretende difundir resultados encontrados en el estudio preliminar del Proyecto de Investigación SEJ 2004-06803 I+D. Se señalan indicadores de uso de competencias informáticas desarrolladas por dos grupos de universitarios españoles y necesidades formativas declaradas para conseguir autonomía en el uso de las competencias informáticas. Las muestras analizadas estuvieron compuestas por dos grupos de estudiantes de primero de Comunicación Audiovisual y tercero de Periodismo de la Universidad Complutense de Madrid. Cada grupo lo conformaron 60 estudiantes que respondieron un cuestionario de naturaleza cuantitativa (escala Likert) y una serie de cuestiones de respuesta cualitativa. Entre las conclusiones encontradas se señala que la edad no es factor determinante para el uso de competencias informáticas. Tampoco lo es la titulación estudiada. Como necesidades formativas declaradas se encuentran una instrucción sistemática en herramientas de uso y una formación educativa que ponga límites al uso relacional de herramientas virtuales.
Service-oriented knowledge management (2012)

Service system is gaining momentum in providing flexible and dynamic solutions for integrated business solutions. Much of this power comes from the global standards imposed on services and synergy through integration. In order to manage service system resources taking into the vast volume of services, knowledge is the key. Existing knowledge concerning services was originally restricted to service providers and a special range of users who are knowledgeable about the services being provided. Therefore, efficient knowledge sharing will be required. The research presented in this paper takes the leverages of service systems and couples the automated knowledge management techniques towards a framework of service oriented knowledge management. In particular, services developed under this research are categorized as system services. The paper explores some generic situations on how system services may interact with external business services in forming application solutions. Under such an approach, dynamic on-demand solutions for an application field can be effectively developed.
Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells (2003)

We report in this paper that the DNA-binding drug mithramycin is a potent inducer of gamma-globin mRNA accumulation and fetal hemoglobin (HbF) production in erythroid cells from healthy human subjects and beta-thalassemia patients. Erythroid precursors derived from peripheral blood were grown in 2-phase liquid culture. In this procedure, early erythroid progenitors proliferate and differentiate during phase 1 (in the absence of erythropoietin) into late progenitors. In phase 2, in the presence of erythropoietin, the latter cells continue their proliferation and mature into Hb-containing orthochromatic normoblasts. Compounds were added on days 4 to 5 of phase 2 (when cells started to synthesize Hb), and cells were harvested on day 12. Accumulation of mRNAs for gamma-globin, beta-globin, alpha-globin, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and beta-actin were measured by real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR); induction of HbF was analyzed by high-performance liquid chromatography (HPLC) and, at cellular level, by flow cytometry. We demonstrated that mithramycin was able to up-regulate preferentially gamma-globin mRNA production and to increase HbF accumulation, the percentage of HbF-containing cells, and their HbF content. Mithramycin was more effective than hydroxyurea, being, in addition, not cytotoxic. This was shown by the lack of cytotoxicity on erythroid and myeloid in vitro primary cell cultures treated with mithramycin at concentrations effective for HbF induction. These results are of potential clinical significance because an increase of HbF alleviates the symptoms underlying beta-thalassemia and sickle cell anemia. The results of this report suggest that mithramycin and its analogs warrant further evaluation as potential therapeutic drugs.
Critical heat flux of counter-current boiling in a vertical tube with a closed bottom. (1991)

An experimental study has been performed on critical heat flux (CHF) of boiling in closed end vertical tubes. Characteristics quite different from those of CHF in ordinary boiling systems have been found, relating to the matters such as the axial location where temperature excursion starts, a considerable time lag in the onset of CHF, and complicated behavior of local wall temperature at CHF. The paper also presents a physical model capable of explaining the appearance of such peculiar phenomena.
Time-domain Measurements of Single-Photon Tunneling Phenomena (2013)

Using a Hong-Ou-Mandel interferometer, we have measured single-photon time delays in frustrated total internal reflection in a liquid-crystal-filled double-prism structure and in transmission through chiral photonic band gap liquid crystal structures with sub-fs resolution.
Oxidative stability of palm‐ and soybean‐based medium‐ and long‐chain triacylglycerol (MLCT) oil blends (2008)

Abstract BACKGROUND: Medium‐ and long‐chain triacylglyerols (MLCT) enzymatically esterified using Lipozyme RM IM lipase has very low oxidative stability as it does not contain any antioxidants. The aim of this work was to study the ability of various antioxidants to increase the oxidative stability of palm‐ and soybean‐based MLCT blends which assist to bring up the oxidative stability of both MLCT blends. In this study, the effectiveness of rosemary extracts, sage extracts, tert ‐butylhydroquinone (TBHQ) and mixtures of tert ‐butyl‐4‐hydroxyanisole (BHA) and tert ‐butyl‐ p ‐hydroxytoluene (BHT) in protecting against oxidation of various MLCT blends was investigated. RESULTS: Blending of MLCT oil with either palm olein or soybean oil improved its smoke point values and oxidative stability. TBHQ addition to both palm‐ and soybean‐based MLCT blends increased oxidative stability. Combination of BHA and BHT showed no significant improvement ( P &gt; 0.05) in ability to protect blends from oxidation compared to natural antioxidants such as sage or rosemary extracts. CONCLUSION: Blended oils with 500 g kg −1 MLCT and 500 g kg −1 palm olein (MP5) were the most suitable for use at high temperature based on the fatty acid composition of the MLCT blends, which subsequently had an effect on thermal oxidative stability. In general, addition of either natural or synthetic antioxidant assisted in improving the antioxidative strength of both MLCT blends. MLCT blends with added TBHQ showed the highest thermal oxidative stability among the antioxidants used. Copyright © 2008 Society of Chemical Industry
Simulation and experimental study on attitude control of quadrotor (2014)

This paper studies dynamic behavior of a quadrotor in both simulation and experiment when tracking desired attitude angles. The flight attitude control implemented in this research is designed based on a feedback control with an inner-loop structure as in the Aeroquad project. The feedback control configuration is applied to the dynamic model of a DIY qaudrotor UAV to simulate its attitude tracking behavior when tuning the PID gains based on a heuristic approach. The well-tuned PID controller is therefore applied to the experiment to validate the desired tracking response.
Durchblick im Arbeitsfenster (1993)

Auf den Installationsvorgang gehen wir nicht ein. Er ist sehr gut im kleinen Manual beschrieben, das zum Programm gehört. Sollte Word nicht auf dem ordentlichen Wege zu Ihnen gekommen sein (weil Sie es vielleicht nur mal kurz ausprobieren wollen), so muß das Verzeichnis auf Ihrer Festplatte vor dem Start aussehen wie das im Bild unten auf der Seite. Sind alle Dateien am richtigen Platz (zum Beispiel die Wörterbücher und Konvertierer im Ordner “Word-Befehle”), so steht dem Arbeiten von Word nichts mehr im Wege.
Autofocusing for Automated Microscopic Evaluation of Blood Smear and Pap Smear (2006)

Autofocusing is a fundamental procedure towards automated microscopic evaluation of blood smear and pap smear samples for clinical diagnosis. This paper presents comparison results of 16 focus algorithms based on a total of 8000 bright-field images from 10 blood smear and pap smear samples. A ranking methodology adapted from our previously proposed ranking system is used for thoroughly evaluating the performance of the selected 16 focus algorithms. Experimental results demonstrate that the variance algorithm provides the best overall performance, which will be selected for our future implementation of an automated microscopic system for computer-assisted blood smear and pap smear evaluation. Together with our previously reported findings, we hypothesize that the variance algorithm or the Normalized variance algorithm is the optimal focus algorithm for all non- fluorescence microscopy applications.
ChemInform Abstract: Organoselenium‐Induced Cyclization of 2‐Alkenylthiazolines to Functionalized γ‐Lactams. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Evaluation of a parallel branch-and-bound algorithm on a class of multiprocessors (1994)

We propose and evaluate a parallel "decomposite best-first" search branch-and-bound algorithm (dbs) for MIN-based multiprocessor systems. We start with a new probabilistic model to estimate the number of evaluated nodes for a serial best-first search branch-and-bound algorithm. This analysis is used in predicting the parallel algorithm speed-up. The proposed algorithm initially decomposes a problem into N subproblems, where N is the number of processors available in a multiprocessor. Afterwards, each processor executes the serial best-first search to find a local feasible solution. Local solutions are broadcasted through the network to compute the final solution. A conflict-free mapping scheme, known as the step-by-step spread, is used for subproblem distribution on the MIN. A speedup expression for the parallel algorithm is then derived using the serial best-first search node evaluation model. Our analysis considers both computation and communication overheads for providing realistic speed-up. Communication modeling is also extended for the parallel global best-first search technique. All the analytical results are validated via simulation. For large systems, when communication overhead is taken into consideration, it is observed that the parallel decomposite best-first search algorithm provides better speed-up compared to other reported schemes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Development and Practice of Store-and-Forward Telehealth Systems in Ophthalmology Dental and Emergency (2015)

Store-and-forward (S&amp;F) telehealth system has been becoming an increasing application in remote medical consultations. In this paper, we will introduce three novel S&amp;F telehealth systems we developed for ophthalmological, dental and emergency applications. We will explain the general system architecture of the S&amp;F systems. Then we will focus on the specific features and components in each system implemented for meeting their respective clinical requirements. In the final section we will present further implementation details and practices and provide discussions.
Combined oral contraceptives: venous thrombosis (2014)

All combined oral contraceptives investigated in this analysis were associated with an increased risk of venous thrombosis. The effect size depended both on the progestogen used and the dose of ethinylestradiol. Risk of venous thrombosis for combined oral contraceptives with 30-35 μg ethinylestradiol and gestodene, desogestrel, cyproterone acetate and drospirenone were similar, and about 50-80% higher than with levonorgestrel. The combined oral contraceptive with the lowest possible dose of ethinylestradiol and good compliance should be prescribed-that is, 30 μg ethinylestradiol with levonorgestrel.
ChemInform Abstract: Synthesis of Substituted Tetrahydropyridines by Cyclizations of Silicon‐Containing Iminium Ions. (1988)

Abstract Iminium ions of type (II), generated from (I), (V) or (VII) (all prepared from L‐alanine), undergo cyclization to yield tetrahydropyridines.
Transcapillary insulin transfer in human skeletal muscle (2003)

In summary there is a substantial transcapillary insulin gradient in healthy human skeletal muscle under baseline and glucose-stimulated conditions. Our findings support the hypothesis of a saturable transcapillary insulin transport representing a partly rate-limiting step for insulin action.
Development and Validation of a Novel Circadian Rhythm‐Related Signature to Predict the Prognosis of the Patients with Hepatocellular Carcinoma (2022)

Hepatocellular carcinoma (HCC) is one of the most important causes of cancer-related deaths and remains a major public health challenge worldwide. Considering the extensive heterogeneity of HCC, more accurate prognostic models are imperative. The circadian genes regulate the daily oscillations of key biological processes, such as nutrient metabolism in the liver. Circadian rhythm disruption has recently been recognized as an independent risk factor for cancer. In this study, The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) were compared and 248 differentially expressed genes (DEGs) of the circadian rhythm were identified. HCC was classified into two subtypes based on these DEGs. The prognostic value of each circadian rhythm-associated gene (CRG) for survival was assessed by constructing a multigene signature from TCGA cohort. A 6-gene signature was created by applying the least absolute shrinkage and selection operator (LASSO) Cox regression method, and all patients in TCGA cohort were divided into high- and low-risk groups according to their risk scores. The survival rate of patients with HCC in the low-risk group was significantly higher than that in the high-risk group (<i>p</i> < 0.001). The patients with HCC in the Gene Expression Omnibus (GEO) cohort were also divided into two risk subgroups using the risk score of TCGA cohort, and the overall survival time (OS) was prolonged in the low-risk group (<i>p</i> = 0.012). Based on the clinical characteristics, the risk score was an independent predictor of OS in the patients with HCC. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses showed that multiple metabolic pathways, cell cycle, etc., were enhanced in the high-risk group. Using the metabolic pathway single-sample gene set enrichment analysis (ssGSEA), it was found that the metabolic pathways in the high- and low-risk groups between TCGA and GEO cohorts were altered essentially in the same way. In conclusion, the circadian genes play an important role in HCC metabolic rearrangements and can be further used to predict the prognosis the patients with HCC.