gebhart/patrepeval huggingface dataset:
Potential Anti‐hyperuricemic Agents from Proanthocyanidins, Procyanidins, and Benzophenone Glucosides via In Silico Docking Analysis Verified with In Vitro Bioassay (2022)

Abstract In a continuation of searching natural xanthine oxidase inhibitors as anti‐hyperuricemic agent, in silico virtual screening of epicatechin ( 1 ) and A‐type proanthocyanidins 2 – 8 , isolated from Machilus philippinensis , by molecular docking was undertaken and subsequent in vitro assay was followed. The bioassay result correlated well with the docking score. Additional A‐type proanthocyanidins 9 – 16 and procyanidins 17 &amp; 18 , present in peanut skin, were isolated and assayed against XO. Although their inhibitory activities were low but correlated well with the docking scores, too. This study indicated in silico virtual docking to be applicable to predict the XO inhibitory activity for proanthocyanidins with the molecular weight ranging from dimers (MW∼550) to hexamers (MW∼1750). For verifying such virtual screening to other phenolics, this approach was extended to benzophenone glucosides 19 – 22 , isolated from Planchonella obovata . Likewise their inhibitory activities against XO correlated well with the docking score. Of these 22 compounds, the tetramer 5 , pentamer 7 , hexamer 8 , and the digalloylated 22 , having the docking score around −25.5 Kcal/mol, showed comparable inhibitory activity against xanthine oxidase to allopurinol (IC 50 ∼40.0 vs. 58.5 μM). Further application of such virtual screening on XO template will keep going for searching potential anti‐hyperuricemic drugs.
Autologous Platelet Gel in Coronary Artery Bypass Grafting: Effects on Surgical Wound Healing (2007)

Stimulating the body's natural healing at the cellular level can be achieved through the application of growth factors located within platelets. Once combined with a mixture of calcium and thrombin, this substance, now referred to as autologous platelet gel (APG), can be applied to surgical wound sites for patients undergoing cardiac surgery. The purpose of this study was to examine the effects of APG on surgical site infection, post-operative pain, blood loss, and bruising. After 30 mL platelet-rich plasma (PRP) was processed, 10 mL PRP was distributed on the sternum after re-approximation and 7 mL PRP before skin closure. Ten milliliters PRP was used on the endoscopic leg harvest (EVH) site. The remaining 3 mL was sent to the laboratory for hematologic testing. Both the control (CTR) and treatment (TRT) groups were well matched, with the exception of ejection fraction and pre-operative platelet count, which was significantly higher in the TRT group. Average platelet count yield was 4.2 +/- 0.5 x 103/mcL, white blood count (WBC) yielded 1.9 +/- 0.7 x 103/mcL, and fibrinogen yielded 1.2 +/- 0.2 mg/dL above baseline. There were no deep or superficial sternal infections. However, one patient from each group did experience a leg infection at the EVH site, which occurred after hospital discharge. More patients in the TRT group experienced less pain on postoperative day (POD) 1 and at the post-operative office follow-up. Blood loss and bruising was less in the TRT group on POD 2; however, there was no statistical significance. The application of APG seems to confer beneficial effects on pain, blood loss, and bruising. However, further studies with a greater sample size are needed to power significant differences.
ChemInform Abstract: A Novel Synthesis of (.+‐.)‐Prostaglandin B1 Methyl Ester. (1988)

Abstract In connection with studies of the new biologically features of PGBx, an oligomeric mixture of the prostaglandin B series, convenient syntheses for the monomeric starting materials, e.g. the ester (III), are required.
Paleofluid evolution in fault damage zones and complex vein networks (Jebel Qusaybah, North Oman) (2013)

Fault- and fold-related fracture systems strongly control fluid flow and diagenesis of carbonates. Using an integrated structural-diagenetic approach, this study aims to reconstruct the fluid circulation history, including hydrocarbons, in fault systems that cross-cut the Natih Formation in Jebel Qusaybah as a part of the North Oman foreland basin. The Natih Formation (Late Albian - Early Turonian) and its time equivalent carbonates are reservoirs in giant oil fields in Middle East. The exposure of Natih Formation carbonates in Jebel Qusaybah provides the opportunity to study the evolution of fluids circulating in the fault and fracture systems in a major reservoir analogue. This jebel consists of a 8.5 km long, E-W-trending anticline affected by widespread NE-SW and NW-SE strike slip and N-S extensional fault zones. Circulation of multiple fluids along these fault zones is recorded by several stages of calcite and localized dolomite cementation in fault cores and damage zone fracture networks. Based on cross-cutting relationships, petrography and geochemical analysis, the calcite cemented fracture-fills and veins can be divided into five main generations related to major deformational events associated with progressive faulting, folding and exhumation. The first calcite phase was likely associated with pre-fold to early N-S compression (-10.3‰< δ18O V-PDB < -6‰ and +1.6‰ < δ13C < +3.5 ‰). The four other calcite generations are associated with syn-faulting events, which can be subdivided into two main stages including: 1) strike slip faulting, with Fe-rich calcites containing hydrocarbon fluid inclusions and displaying a wide range of 18O values and more clustered δ13C compositions (-11.2‰ < δ18O V-PDB < -1.15 ‰ and +0.25‰ < δ13C < +3 ‰). The wide range of δ18O may relate to different thermal regimes during the structural development of the Qusaybah anticline, or to the involvement of fluids of different origins. 2) N-S extensional faulting (fold-related), with Fe-intermediate to Fe-poor calcites, containing solid bitumen inclusions and less depleted δ18O values and high δ13C values (-3‰< δ18O V-PDB < +1.5 ‰ and +3.5‰ < δ13C < +8 ‰). Whether the high δ13C signature of vein and fault fills is the result of bacterial methanogenesis or CO2 degassing is under investigation. The presence of monophase aqueous fluid inclusions in these calcites suggests precipitation temperatures below 50°C. Relatively high 87Sr/86Sr in all generations of Fe-rich calcites (0.7080-0.7082) suggests the inflow of fluids that had interacted with siliciclastics and/or basement rocks. This study highlights the importance of structurally controlled diagenesis in the porosity development and fluid conduits created by faults and fractures, especially if the latter occur in potential hydrocarbon reservoirs.
On the Use of Ontology as A Priori Knowledge into Constrained Clustering (2016)

Recent studies have shown that the use of a priori knowledge can significantly improve the results of unsupervised classification. However, capturing and formatting such knowledge as constraints is not only very expensive requiring the sustained involvement of an expert but it is also very difficult because some valuable information can be lost when it cannot be encoded as constraints. In this paper, we propose a new constraint-based clustering approach based on ontology reasoning for automatically generating constraints and bridging the semantic gap in satellite image labeling. The use of ontology as a priori knowledge has many advantages that we leverage in the context of satellite image interpretation. The experiments we conduct have shown that our proposed approach can deal with incomplete knowledge while completely exploiting the available one.
Effect of ballast water treatment system on survivorship of natural populations of marine plankton (2001)

A field experiment was carried out to determine the influence of a 2-stage ballast water treatment system on the survivorship of natural populations of plankton. This Integrated Cyclone-UV Treatment System (ITS) was designed and constructed by Velox Technology Inc. and consisted of 2 treatment phases: (1) the cyclonic pre-treatment phase, (2) the ultraviolet-radiation phase (UV-C). The ITS was deployed on the Vancouver Port Authority dock, British Columbia on April 11, 1999. Seawater samples were collected from ports located along the treatment stages of the ITS and analyzed for plankton survivorship. The sampling stages were defined as Pre-Intake, Pre-Cyclone, Post-Cyclone, Post-Solids, and Post-UV-on and Post-UV-off. The survivorship of planktonic invertebrates was assessed immediately through direct observations, while phytoplankton survivorship was assessed through incubation grow-out experiments. With respect to zooplankton, live copepods were observed in the Pre-Intake and Pre-Cyclone samples, while dead or moribund copepods were observed in samples collected from both early and late stages of the ITS. Statistical comparisons were carried out on phytoplankton growth parameters such as starting concentration, lag phase, growth rate, and relative abundance generated during the incubation experiment. Chaetoceros gracile appeared to be the most sensitive organism to the ITS as it exhibited a 4 d lag phase prior to growth. The starting concentration, growth rate, and relative abundance of this species observed in the Post UV-on samples were significantly lower than those observed in the Pre-Intake samples (control). In addition, the auxospores formed by Skeletonema costatum during the incubation experiment were observed in all treatment samples with the exception of those exposed to the Post-UV-on stage of the ITS. A second phytoplankton incubation experiment was carried out using the original samples following a 3 mo storage period in dark, cold conditions (4C). The results of this experiment revealed that the phytoplankton population in the UV-treated samples was not capable of growth, while those in the remaining treatments exhibited growth. Thus, future studies assessing the effect of the ITS on phytoplankton survivorship should incorporate increases in the intensity and exposure period of ultraviolet radiation followed by a dark, cold-storage period, thereby reducing the chance of photorepair.
Optimizing NAT and Firewall Keepalives Using Port Control Protocol (PCP) (2015)

This document describes how Port Control Protocol is useful in
reducing NAT and firewall keepalive messages for a variety of
applications.
Generic implementation of a modular GCD over Algebraic Extension Fields (2009)

We report on several generic implementations for uni-variate polynomial gcd computation over the integers and, in particular, over algebraic extensions. Our benchmarks show that the generic implementation compares favorably to well established libraries. Even for the integer case our implementation is competitive to the one provided by the NTL, which does not sup-port algebraic extensions. Our software is part of the new Polynomial package of Cgal release 3.4. 1
Ad-hoc on-demand distance vector routing (1999)

An ad-hoc network is the cooperative engagement of a collection of mobile nodes without the required intervention of any centralized access point or existing infrastructure. We present Ad-hoc On Demand Distance Vector Routing (AODV), a novel algorithm for the operation of such ad-hoc networks. Each mobile host operates as a specialized router, and routes are obtained as needed (i.e., on-demand) with little or no reliance on periodic advertisements. Our new routing algorithm is quite suitable for a dynamic self starting network, as required by users wishing to utilize ad-hoc networks. AODV provides loop-free routes even while repairing broken links. Because the protocol does not require global periodic routing advertisements, the demand on the overall bandwidth available to the mobile nodes is substantially less than in those protocols that do necessitate such advertisements. Nevertheless we can still maintain most of the advantages of basic distance vector routing mechanisms. We show that our algorithm scales to large populations of mobile nodes wishing to form ad-hoc networks. We also include an evaluation methodology and simulation results to verify the operation of our algorithm.
Risk-Constrained Stochastic Virtual Bidding in Two-Settlement Electricity Markets (2018)

Virtual bidding is a financial instrument implemented by most two-settlement electricity markets in the United States in which the profits of the virtual traders are determined by the electricity prices in the day-ahead and real-time energy markets. This paper proposes stochastic optimization models to generate optimal bidding strategies for virtual traders. In the proposed models, the scenarios of electricity prices are generated by using the seasonal autoregressive integrated moving average (SARIMA) model and reduced to a small number by using a fast forward scenario reduction algorithm; and the conditional value at risk (CVaR) is used for risk management for the virtual trader. By using the proposed stochastic optimization models, either an optimal increment or decrement bidding curve can be generated for each hour of the operating day. Case studies using real-world data are carried out for a virtual trader using the proposed models. Results show that the proposed models can help the virtual trader earn profits by using the price differences in the day-ahead and real-time markets effectively, and the bidding strategy of a virtual trader is very sensitive to its risk aversion degree.
Surface waves in defocusing thermal nonlinear optical media (2007)

We predict that the interface of materials with defocusing thermal nonlinearities support stable fundamental and higher-order surface waves when the opposite edges of the medium are maintained at different temperatures. Such surface waves exist due to the interplay between repulsion from the interface and the defocusing thermal nonlinearity that deflect light beams from the bulk of the medium toward its edges.
Nonlinear refractive index in erbium doped optical fiber: Theory and experiment (1991)

An intensity-dependent refractive index in erbium doped optical fiber has been observed for the first time. The effect has been observed by an interferometric technique using a two-core fiber. The effect is analyzed theoretically, and the important nonlinear parameters for thin material have been determined and are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Geometric Capsule Autoencoders for 3D Point Clouds (2019)

We propose a method to learn object representations from 3D point clouds using bundles of geometrically interpretable hidden units, which we call geometric capsules. Each geometric capsule represents a visual entity, such as an object or a part, and consists of two components: a pose and a feature. The pose encodes where the entity is, while the feature encodes what it is. We use these capsules to construct a Geometric Capsule Autoencoder that learns to group 3D points into parts (small local surfaces), and these parts into the whole object, in an unsupervised manner. Our novel Multi-View Agreement voting mechanism is used to discover an object's canonical pose and its pose-invariant feature vector. Using the ShapeNet and ModelNet40 datasets, we analyze the properties of the learned representations and show the benefits of having multiple votes agree. We perform alignment and retrieval of arbitrarily rotated objects -- tasks that evaluate our model's object identification and canonical pose recovery capabilities -- and obtained insightful results.
A Field Guide to Pandemic, Epidemic and Sporadic Clones of Methicillin-Resistant Staphylococcus aureus (2011)

In recent years, methicillin-resistant Staphylococcus aureus (MRSA) have become a truly global challenge. In addition to the long-known healthcare-associated clones, novel strains have also emerged outside of the hospital settings, in the community as well as in livestock. The emergence and spread of virulent clones expressing Panton-Valentine leukocidin (PVL) is an additional cause for concern. In order to provide an overview of pandemic, epidemic and sporadic strains, more than 3,000 clinical and veterinary isolates of MRSA mainly from Germany, the United Kingdom, Ireland, France, Malta, Abu Dhabi, Hong Kong, Australia, Trinidad & Tobago as well as some reference strains from the United States have been genotyped by DNA microarray analysis. This technique allowed the assignment of the MRSA isolates to 34 distinct lineages which can be clearly defined based on non-mobile genes. The results were in accordance with data from multilocus sequence typing. More than 100 different strains were distinguished based on affiliation to these lineages, SCCmec type and the presence or absence of PVL. These strains are described here mainly with regard to clinically relevant antimicrobial resistance- and virulence-associated markers, but also in relation to epidemiology and geographic distribution. The findings of the study show a high level of biodiversity among MRSA, especially among strains harbouring SCCmec IV and V elements. The data also indicate a high rate of genetic recombination in MRSA involving SCC elements, bacteriophages or other mobile genetic elements and large-scale chromosomal replacements.
Percepción de los estudiantes en relación con el cumplimiento de los resultados del aprendizaje formulados en los planes de estudios de las asignaturas Recursos Humanos I y II (2015)

Se determino la percepcion de los estudiantes en relacion con su dominio de los objetivos de aprendizaje formulados en los planes de estudio de las asignaturas Recursos Humanos I y II de las carreras correspondientes a los dos ultimos semestres de las carreras de Administracion de Empresas y Administracion Publica de la Universidad Central del Ecuador. La evaluacion se efectuo aplicando una encuesta de 22 preguntas, en que cada una corresponde a un objetivo de aprendizaje de las dos asignaturas mencionadas y los estudiantes valoraron su dominio con el empleo de una escala de Likert de 5 puntos.  La validacion de la consistencia interna del cuestionario aplicado se realizo con una muestra de 21 alumnos obteniendose un valor de 0,89 para el coeficiente Alpha de Crombach. Para una interpretacion de los resultados los objetivos de aprendizaje se agruparon en cinco categorias que se corresponden al perfil laboral que encontraria el posible graduado en un Area de Recursos Humanos de una Empresa. Se obtuvo que los objetivos de aprendizaje que se corresponden a la Valoracion y Clasificacion de Puestos  son aquellos que los estudiantes dicen dominar menos, siguiendole el Reclutamiento y Seleccion del Personal. Los resultados alcanzados apuntan a poder investigar los objetivos de aprendizaje desde la perspectiva del criterio del estudiante, que aunque pueda considerarse subjetivo (percepcion), expresa indiscutiblemente el grado de seguridad con el que enfrentara una posible responsabilidad laboral en una empresa.
High-Resolution Structure of the Eukaryotic 80S Ribosome (2014)

The high-resolution structure of the eukaryotic ribosome from yeast, determined at 3.0-Å resolution, permitted the unambiguous determination of the protein side chains, eukaryote-specific proteins, protein insertions, and ribosomal RNA expansion segments of the 80 proteins and ∼5,500 RNA bases that constitute the 80S ribosome. A comparison between this first atomic model of the entire 80S eukaryotic ribosome and previously determined structures of bacterial ribosomes confirmed early genetic and structural data indicating that they share an evolutionarily conserved core of ribosomal RNA and proteins. It also confirmed the conserved organization of essential functional sites, such as the peptidyl transferase center and the decoding site. New structural information about eukaryote-specific elements, such as expansion segments and new ribosomal proteins, forms the structural framework for the design and analysis of experiments that will explore the eukaryotic translational apparatus and the evolutionary forces that shaped it. New nomenclature for ribosomal proteins, based on the names of protein families, has been proposed.
Antioxidant and antibacterial activities of peptide fractions from flaxseed protein hydrolysed by protease from Bacillus altitudinis HK02 (2016)

Summary Flaxseed protein (FP) hydrolysates by crude protease of strain Bacillus altitudinis HK 02 were further separated into five fractions by ultrafiltration membranes with a molecular weight cut‐off of 10, 5, 3 and 1 kDa for the analysis of antioxidant activities and antibacterial ability. The results demonstrated that the fraction of 1‐ to 3‐kDa peptides exhibited higher antioxidant activities on the free radical‐scavenging ability and the reducing power than those of Vit C, Vit E, BHA and other fractions. The fraction with a low molecular weight (&lt;1 kDa) of peptides demonstrated the highest ferrous ion‐chelating ability and a higher inhibition of lipid peroxidation than BHA and other fractions. Moreover, it also exhibited the best growth inhibition of Pseudomonas aeruginosa and Escherichia coli . The results, including the concentration‐dependent effect of peptides fractions, demonstrated that it is feasible to derive functional ingredients of natural antioxidants along with antimicrobial activity from FPs hydrolysed by protease from B. altitudinis HK02.
Assembly of the functional membrane attack complex of human complement: formation of disulfide-linked C9 dimers. (1981)

The 158,000 Mr protein, previously designated C5c, present in fully assembled complement (C) membrane attack complexes (MC5b-9) has been identified as a disulfide-bonded dimer of C9. This conclusion was based on the observations that: (i) a portion of the 125I-radiolabeled precursor C9 incorporated into MC5b-9 complexes comigrated with the 158,000 Mr protein band in NaDodSO4/polyacrylamide slab gels; (ii) monospecific antisera produced against native C9 and the 158,000 Mr protein immunologically crossreacted with monomeric native C9 by double immunodiffusion and with monomeric C9 and the 158,000 Mr protein on immunoreplication procedures; and (iii) two-dimensional NaDodSO4/polyacrylamide slab gel electrophoresis, in which the second dimension was conducted under reducing conditions, revealed that the 158,000 Mr protein contained two identical 71,000 Mr subunits which comigrated with monomeric C9. Molar ratio estimates indicated that 1 mol of C5b, C9 dimer, C6, C7, and C8 and 3-4 mol of C9 monomer were present per MC5b-9 complex. Each fully assembled membrane-bound MC5b-9 complex would therefore have a calculated Mr of 982,000. The presence of C9 dimers in the hemolytically active 29S dimeric form of the MC5b-9 complex and the absence of C9 dimers in the hemolytically inactive 23S monomeric form of the fluid phase SC5b-9 complex strongly suggest an important role for C9 dimer formation in MC5b-9 complex structure and function. The most probable function of C9 dimers would be the formation of intercomplex disulfide crosslinks which would provide a mechanism to stabilize the assembly of MC5b-9 into aggregates of increasing size on the target membrane surface which would thus be responsible for the observed pore size heterogeneity of functional C lesions.
High-Power Battery Testing Procedures and Analytical Methodologies for HEV's (2002)

&lt;div class="htmlview paragraph"&gt;Novel testing procedures and analytical methodologies to assess the performance of hybrid electric vehicle batteries have been developed. Tests include both characterization and cycle life and/or calendar life, and have been designed for both Power Assist and Dual Mode applications. Analytical procedures include a battery scaling methodology, the calculation of pulse resistance, pulse power, available energy, and differential capacity, and the modeling of calendar- and cycle-life data. Representative performance data and examples of the application of the analytical methodologies including resistance growth, power fade, and cycle- and calendar-life modeling for hybrid electric vehicle batteries are presented.&lt;/div&gt;