gebhart/patrepeval huggingface dataset:
Controllable pulse compression in a multiple-pass-cell Raman laser (1980)

Pulse compression has been observed with the 16-microm multiple-pass-cell hydrogen Raman laser. The effect, which also leads to high quantum conversion of the pump radiation, has been analyzed and is a result of beam crossings inherent in the geometry of the device.
Structural characterization of selenosubtilisin by selenium-77 NMR spectroscopy (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural characterization of selenosubtilisin by selenium-77 NMR spectroscopyKaren L. House, R. Bruce Dunlap, Jerome D. Odom, Zhen Ping Wu, and Donald HilvertCite this: J. Am. Chem. Soc. 1992, 114, 22, 8573–8579Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/ja00048a033https://doi.org/10.1021/ja00048a033research-articleACS PublicationsRequest reuse permissionsArticle Views447Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Practical Secure Logging: Seekable Sequential Key Generators (2013)

In computer forensics, log files are indispensable resources that support auditors in identifying and understanding system threats and security breaches. If such logs are recorded locally, i.e., stored on the monitored machine itself, the problem of log authentication arises: if a system intrusion takes place, the intruder might be able to manipulate the log entries and cover her traces. Mechanisms that cryptographically protect collected log messages from manipulation should ideally have two properties: they should be forward-secure (the adversary gets no advantage from learning current keys when aiming at forging past log entries), and they should be seekable (the auditor can verify the integrity of log entries in any order, at virtually no computational cost).We propose a new cryptographic primitive, a seekable sequential key generator (SSKG), that combines these two properties and has direct application in secure logging. We rigorously formalize the required security properties and give a provably-secure construction based on the integer factorization problem. We further optimize the scheme in various ways, preparing it for real-world deployment. As a byproduct, we develop the notion of a shortcut one-way permutation (SCP), which might be of independent interest.Our work is highly relevant in practice. Indeed, our SSKG implementation has become part of the logging service of the systemd system manager, a core component of many modern commercial Linux-based operating systems.
Differential detection of nuclear envelope autoantibodies in primary biliary cirrhosis using routine and alternative methods (2010)

The prevalence of ANEA or anti-gp210 antibodies is under-estimated in PBC sera which are analyzed by conventional commercially available IIF or ELISA, respectively. Therefore, new substrates for IIF and ELISA should be included by clinical laboratories in the analysis of ANEA in autoimmune sera.
Discriminative Deep Feature Visualization for Explainable Face Recognition (2023)

Despite the huge success of deep convolutional neural networks in face recognition (FR) tasks, current methods lack explainability for their predictions because of their "black-box" nature. In recent years, studies have been carried out to give an interpretation of the decision of a deep FR system. However, the affinity between the input facial image and the extracted deep features has not been explored. This paper contributes to the problem of explainable face recognition by first conceiving a face reconstruction-based explanation module, which reveals the correspondence between the deep feature and the facial regions. To further interpret the decision of an FR model, a novel visual saliency explanation algorithm has been proposed. It provides insightful explanation by producing visual saliency maps that represent similar and dissimilar regions between input faces. A detailed analysis has been presented for the generated visual explanation to show the effectiveness of the proposed method.
Transcription of Bacteriophage PM2 (1983)

Transcription of bacteriophage PM2 after infection of Alteromonas espejiana BAL-31 was examined. A wave of PM2 late transcription was observed 22 to 44 min after infection. This transcription was chloramphenicol- and rifampicin-sensitive. Regions of PM2 DNA transcribed with high efficiency were determined by DNA--RNA hybridization and Southern's technique.
Artin formalism for Selberg zeta functions of co-finite Kleinian groups (2008)

Let $Γ\backslash\mathbb H^3$ be a finite-volume quotient of the upper-half space, where $Γ\subset {\rm SL}(2,\mathbb C)$ is a discrete subgroup. To a finite dimensional unitary representation $χ$ of $Γ$ one associates the Selberg zeta function $Z(s;Γ;χ)$. In this paper we prove the Artin formalism for the Selberg zeta function. Namely, if $\tildeΓ$ is a finite index group extension of $Γ$ in ${\rm SL}(2,\mathbb C)$, and $π={\rm Ind}_Γ^{\tildeΓ}χ$ is the induced representation, then $Z(s;Γ;χ)=Z(s;\tildeΓ;π)$. In the second part of the paper we prove by a direct method the analogous identity for the scattering function, namely $ϕ(s;Γ;χ)=ϕ(s;\tildeΓ;π)$, for an appropriate normalization of the Eisenstein series.
Synthesis of the Hexasaccharide Fragment of Landomycin A Using a Mild, Reagent-Controlled Approach (2019)

The synthesis of the hexasaccharide fragment of landomycin A is reported. Using p-toluenesulfonyl chloride mediated dehydrative glycosylation, we constructed the deoxy-sugar linkages in a stereoselective fashion without the need for temporary prosthetic groups to control selectivity. Through this approach, the hexasaccharide was obtained in 28 steps and 8.9% overall yield, which is an order of magnitude higher than that of previously reported approaches.
Saturated heterocycles, 162 [1]. synthesis and steric structures of 3,4‐disubstituted 1,6,7,11b‐tetrahydropyrimido[6,1‐a]isoquinolin‐2‐ones (1990)

Abstract The reaction of 1‐(hydrazidomethyl)‐6,7‐dimethoxy‐1,2,3,4‐tetrahydroisoquinoline 3 with aromatic aldehydes yield hydrazones 4a,b or pyrimido[6,1‐ a ]isoquinolines 5a‐c depending upon the proportions of the reagents. With ketones, 3 gives only hydrazones 4a‐d and 7 , which can be transformed to pyrimidoisoquinolines 10a‐e and 11 with aldehydes. The ring closures are stereospecific; the relative configurations were determined by DNOE measurements.
Response function for gain and refractive index dynamics in active semiconductor waveguides (1994)

Based on semiclassical density matrix equations, we derive a simple analytical expression for the pump-probe response function of an active semiconductor optical waveguide. The results are in good agreement with published pump-probe measurements of gain and refractive index dynamics in laser amplifiers. In particular, an experimentally observed delay in carrier heating is explained, and spectral effects not previously considered are shown to be significant under typical experimental conditions.
Introduction (2018)

No AccessThermoformingDec 2018IntroductionPeter Schwarzmann, Adolf IlligPeter SchwarzmannSearch for more papers by this author, Adolf IlligSearch for more papers by this authorhttps://doi.org/10.3139/9781569907092.001SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2018Pages: 1-4Print ISBN: 978-1-56990-708-5eISBN: 978-1-56990-709-2 Copyright & Permissions© 2019 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Contribución del sector privado a las áreas protegidas : estudios en Colombia y Perú (2014)

Esta publicacion se enmarca en el proyecto “Implementacion del Acuerdo sobre Medio Ambiente entre Canada y Peru y del Acuerdo sobre Medio Ambiente entre Canada y Colombia”, ejecutado por la Oficina de la Union Internacional para la Conservacion de la Naturaleza para America del Sur, con el apoyo financiero de Environment Canada (Ministerio de Medio Ambiente de Canada). Se trata de una investigacion acerca de los instrumentos previstos en los marcos legales y reglamentarios en ambos paises que facilitan la vinculacion del sector privado con aportes directos dirigidos a financiar  actividades para una adecuada gestion de las areas protegidas publicas y privadas. Se presenta asimismo un caso de aplicacion practica de estas. herramientas.
Familial aggregation of dyslexia phenotypes. II: Paired correlated measures (2002)

Abstract Dyslexia is a common and complex behavioral disorder characterized by unexpected difficulty in learning to read. Psychometric measures used to assess dyslexia often evaluate overlapping processes or abilities. To identify subphenotypes amenable to model‐based linkage analyses, we have used careful language phenotyping, familial aggregation analyses of single phenotype measures, and segregation analyses. In the current study, to identify covariates to use in future segregation analyses we examined six pairs of related measures selected from among the most promising candidates in the initial aggregation analyses whose aggregation patterns were most consistent with a genetic basis. For these reciprocal aggregation analyses each measure is evaluated with the paired measure as the covariate to obtain information about the interdependence of the paired measures on shared genetic factors. Six pairs of measures were evaluated: 1) accuracy and efficiency of phonological decoding; 2) phonological nonword memory and written spelling; 3) phonological decoding accuracy and written spelling; 4) inattention ratings and rapid automatized naming for switching letters and numerals (RAS); 5) inattention ratings and oral reading rate; and 6) RAS and oral reading rate. Results of these analyses provide evidence that there may be a genetic contribution to efficiency of phonological decoding in addition to the genetic contribution it shares with accuracy of phonological decoding, a genetic contribution to phonological nonword memory in addition to the genetic contribution it shares with written spelling, a genetic contribution to written spelling in addition to the genetic contribution it shares with accuracy of phonological decoding, and a genetic contribution to inattention ratings in addition to the genetic contribution it shares with either RAS or oral reading rate. © 2002 Wiley‐Liss, Inc.
Reactions of Decamethylhafnocene with 1,3-Butadiynes: Formation of Hafnacyclocumulenes and C−H Activation at Pentamethylcyclopentadienyl Ligands (2007)

The reduction of Cp*2HfCl2 with lithium in the presence of disubstituted butadiynes RC≡C−C≡CR (R = Ph, SiMe3, t-Bu) in toluene leads, respectively, to the five-membered hafnacyclocumulene complexes Cp*2Hf(η4-1,2,3,4-PhC4Ph) (1-Hf) and Cp*2Hf(η4-1,2,3,4-Me3SiC4SiMe3) (2-Hf) and, in the case of 1,4-bis(tert-butyl)butadiyne by a 2-fold activation of the methyl groups of one pentamethylcyclopentadienyl ligand, to the complex Cp*Hf[−C(═C═CH-t-Bu)−CH(t-Bu)CH2−η5-C5Me3−CH2−] (3-Hf) containing a fulvene ligand that is coupled to the modified substrate (allenic subunit). The latter inserts 2 equiv of the isocyanide t-BuNC to give by coupling of the isocyanide molecules the complex Cp*Hf[−C(═C═CH-t-Bu)−CH(t-Bu)CH2−η5-C5Me3−CH2−C(═N-t-Bu)−C(═N-t-Bu)−] (4). The structures of complexes 3-Hf and 4 were determined by X-ray crystallography.
[WHO classification of tumors of the breast, 2012]. (2013)

The classification of tumors of the breast was revised and considerably modified in 2012. The main modifications were applied to epithelial tumors. The clinical types of breast cancer were identified. These were inflammatory and bilateral carcinomas. No substantial amendments were made in the classification of mesenchymal tumors. This paper discusses the new WHO classification of tumors of the breast, 2012, by describing the histological forms and immunohistochemical profile of neoplasms in detail. Its dissimilarities from the previous edition are given. The systems for evaluating medical pathomorphism are detailed.
Catalyst-free synthesis of transparent, mesoporous diamond monoliths from periodic mesoporous carbon CMK-8 (2010)

We report on the synthesis of optically transparent, mesoporous, monolithic diamond from periodic mesoporous carbon CMK-8 at a pressure of 21 GPa. The phase transformation is already complete at a mild synthesis temperature of 1,300 °C without the need of a catalyst. Surprisingly, the diamond is obtained as a mesoporous material despite the extreme pressure. X-ray diffraction, SEM, transmission electron microscopy, selected area electron diffraction, high-resolution transmission electron microscopy, and Z-contrast experiments suggest that the mesoporous diamond is composed of interconnected diamond nanocrystals having diameters around 5–10 nm. The Brunauer Emmett Teller surface area was determined to be 33 m 2 g -1 according Kr sorption data. The mesostructure is diminished yet still detectable when the diamond is produced from CMK-8 at 1,600 °C and 21 GPa. The temperature dependence of the porosity indicates that the mesoporous diamond exists metastable and withstands transformation into a dense form at a significant rate due to its high kinetic inertness at the mild synthesis temperature. The findings point toward ultrahard porous materials with potential as mechanically highly stable membranes.
A Double-Blind, Randomized, Fixed-Dose Trial of Fluoxetine vs. Amitriptyline in the Treatment of Major Depression Complicating Alzheimer's Disease (1997)

The objective of this study was to determine the relative efficacy and safety of fluoxetine and amitriptyline in the treatment of major depression complicating Alzheimer's disease (AD). The sample included 37 patients with AD and major depression. The study design was a double-blind, fixed-dose, randomized clinical trial with 45 days of follow-up. The outcome measures were the Hamilton Depression Rating Scale (Ham-D), the Mini-Mental State Exam (MMSE), and the number of dropouts from each arm of the study. Efficacy was similar for fluoxetine and amitriptyline. At Day 45, there was a mean 9.4-point reduction in Ham-D scores (t[df,62] = 9.68, P < 0.0001) and a 2.4-point mean increase in MMSE scores as compared to baseline (t[df,2] = 2.69, P = 0.009). Eleven (58%) of the amitriptyline-treated patients dropped out, compared with 4 (22%) of the fluoxetine-treated patients (chi 2[df,2] = 8.9, P = 0.017). The authors conclude that antidepressant treatment for major depression complicating AD is effective. While fluoxetine and amitriptyline are equally effective, fluoxetine is better tolerated.
Continuous production of flexible carbon nanotube-based transparent conductive films (2010)

This work shows a simple, single-stage, scalable method for the continuous production of high-quality carbon nanotube-polymer transparent conductive films from carbon feedstock. Besides the ease of scalability, a particular advantage of this process is that the concentration of nanotubes in the films, and thus transparency and conductivity, can be adjusted by changing simple process parameters. Therefore, films can be readily prepared for any application desired, ranging from solar cells to flat panel displays. Our best results show a surface resistivity of the order of 300 Ω square<sup>-1</sup> for a film with 80% transparency, which is promising at this early stage of process development.
Identification by flow cytometry of Seiridin, one of the main phytotoxins produced by three Seiridium species pathogenic to cypress (2006)

Seiridin (SE), one of the main phytotoxins produced in vitro by Seiridium species pathogenic to cypress, was oxidized and the corresponding ketone derivative covalently linked to bovine serum albumin (BSA). The conjugate (SE-BSA) was used to prepare an antiserum to SE. The antibodies were absorbed with BSA and their specificity was assayed by ELISA and flow cytometry against SE, iso-seiridin (ISE), a structural isomer of SE, and some derivatives of these two metabolites. The antibodies tested in a competitive indirect ELISA did not show any binding activity to SE, ISE and their derivatives. The cytometry test, instead, was successful. SE-BSA and SE showed the highest binding activity with the antibodies. SE derivatives having a shift on the adjacent carbon, oxidation, or acetylation of the hydroxy group of the heptyl side chain at C-4 or conversion of the gamma-lactone in the corresponding planar furane ring reacted less than SE. The 2'-dansylhydrazoneSE and the 3,4-dihydroSE having a bulky group attached to the heptyl side chain and a saturated lactone ring, respectively, showed a weak reactivity. SE derivatives in which the gamma-lactone ring was destroyed and ISE derivatives presenting the shift of the hydroxy group at C-3' and another structural modification had no binding activity.
Non-peptidic Cruzain Inhibitors with Trypanocidal Activity Discovered by Virtual Screening and In Vitro Assay (2013)

A multi-step cascade strategy using integrated ligand- and target-based virtual screening methods was developed to select a small number of compounds from the ZINC database to be evaluated for trypanocidal activity. Winnowing the database to 23 selected compounds, 12 non-covalent binding cruzain inhibitors with affinity values (K i) in the low micromolar range (3-60 µM) acting through a competitive inhibition mechanism were identified. This mechanism has been confirmed by determining the binding mode of the cruzain inhibitor Nequimed176 through X-ray crystallographic studies. Cruzain, a validated therapeutic target for new chemotherapy for Chagas disease, also shares high similarity with the mammalian homolog cathepsin L. Because increased activity of cathepsin L is related to invasive properties and has been linked to metastatic cancer cells, cruzain inhibitors from the same library were assayed against it. Affinity values were in a similar range (4-80 µM), yielding poor selectivity towards cruzain but raising the possibility of investigating such inhibitors for their effect on cell proliferation. In order to select the most promising enzyme inhibitors retaining trypanocidal activity for structure-activity relationship (SAR) studies, the most potent cruzain inhibitors were assayed against T. cruzi-infected cells. Two compounds were found to have trypanocidal activity. Using compound Nequimed42 as precursor, an SAR was established in which the 2-acetamidothiophene-3-carboxamide group was identified as essential for enzyme and parasite inhibition activities. The IC50 value for compound Nequimed42 acting against the trypomastigote form of the Tulahuen lacZ strain was found to be 10.6±0.1 µM, tenfold lower than that obtained for benznidazole, which was taken as positive control. In addition, by employing the strategy of molecular simplification, a smaller compound derived from Nequimed42 with a ligand efficiency (LE) of 0.33 kcal mol(-1) atom(-1) (compound Nequimed176) is highlighted as a novel non-peptidic, non-covalent cruzain inhibitor as a trypanocidal agent candidate for optimization.
Football injuries in Oslo: a one-year study. (1984)

All football injuries treated at the Emergency Department, Oslo City Hospital, 1329 patients, 1167 males and 162 females, were recorded for one year, accounting for 28.4% of all sports injuries. Most injuries seen were in the 15-19 years age group in females and 20-24 years age group in males; 68% of the females and 42% of the males (p less than 0.001) were below 20 years of age, and 87% of the injuries occurred in competitive football. During matches, 695 players were injured giving an incidence of 34.5 injuries/10,000 player matches. The injuries occurred all year with a peak in June. Sprains accounted for 41% of the injuries, 23% were contusions and 19% fractures. Most injuries (59%) affected the legs. Hospital admission was required for three females and 57 males. The football injuries required 1966 consultations and necessitated that 349 patients had to stay away from work for a total of 6137 days.
Efficacy of an intramuscular bivalent norovirus GI.1/GII.4 virus-like particle vaccine candidate in healthy US adults (2020)

Despite limited cases of homotypic norovirus AGE meaning the primary endpoint was not fully evaluable, we showed TAK-214 provided statistically significant efficacy against "any moderate/severe norovirus AGE" principally caused by the heterotypic GII.2 genotype, demonstrating induction of cross-genotype protection.
Association of Optical Coherence Tomography and Optical Coherence Tomography Angiography Retinal Features With Visual Function in Older Adults (2022)

In this cross-sectional study, better CS was associated with greater RNFL thickness and GCC thickness, but no visual measures were associated with angiographic features overall. These findings suggest that clinical application of normative references for OCT- and OCTA-based measures should consider demographic and community features.
Prevalence of Substance Use Disorders by Time Since First Substance Use Among Young People in the US (2021)

Discussion | As the first study, to our knowledge, of the association between participation in an existing large-scale preschool program and adult BMI, we found CPC participation was associated with significantly lower rates of adult BMI. This was especially apparent for high-risk groups, where reductions in obesity prevalence were up to 29%.
Looking for pathways related to COVID-19 phenotypes: Confirmation of pathogenic mechanisms by SARS-CoV-2 - Host interactome (2020)

Abstract In the last months, many studies have clearly described several mechanisms of SARS-CoV-2 infection at cell and tissue level. Host conditions and comorbidities were identified as risk factors for severe and fatal disease courses, but the mechanisms of interaction between host and SARS-CoV-2 determining the grade of COVID- 19 severity, are still unknown. We provide a network analysis on protein–protein interactions (PPI) between viral and host proteins to better identify host biological responses, induced by both whole proteome of SARS-CoV-2 and specific viral proteins. A host-virus interactome was inferred on published PPI, using an explorative algorithm (Random Walk with Restart) triggered by all the 28 proteins of SARS-CoV-2, or each single viral protein one-by-one. The functional analysis for all proteins, linked to many aspects of COVID-19 pathogenesis, allows to identify the subcellular districts, where SARS-CoV-2 proteins seem to be distributed, while in each interactome built around one single viral protein, a different response was described, underlining as ORF8 and ORF3a modulated cardiovascular diseases and pro-inflammatory pathways, respectively. Finally, an explorative network-based approach was applied to Bradykinin Storm, highlighting a possible direct action of ORF3a and NS7b to enhancing this condition. This network-based model for SARS-CoV-2 infection could be a framework for pathogenic evaluation of specific clinical outcomes. We identified possible host responses induced by specific proteins of SARS-CoV-2, underlining the important role of specific viral accessory proteins in pathogenic phenotypes of severe COVID-19 patients.