gebhart/patrepeval huggingface dataset:
Purification of air-sensitive organometallic compounds by a modified flash chromatography procedure (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPurification of air-sensitive organometallic compounds by a modified flash chromatography procedureKenneth A. M. Kremer and Paul HelquistCite this: Organometallics 1984, 3, 11, 1743–1745Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published inissue 1 November 1984https://pubs.acs.org/doi/10.1021/om00089a025https://doi.org/10.1021/om00089a025research-articleACS PublicationsRequest reuse permissionsArticle Views816Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
C-Peptide Increases Na,K-ATPase Expression via PKC- and MAP Kinase-Dependent Activation of Transcription Factor ZEB in Human Renal Tubular Cells (2011)

Despite activation of ERK1/2 and PKC by hyperglycemia, a distinct pool of PKCs and ERK1/2 is involved in regulation of Na,K-ATPase expression and activity by C-peptide. Most likely C-peptide stimulates sodium pump expression via activation of ZEB, a transcription factor that has not been previously implicated in C-peptide-mediated signaling. Importantly, only physiological concentrations of C-peptide elicit this effect.
Clinical genetics: A source book for physicians (1979)

CLINICAL GENETICS : a source book for physicians , CLINICAL GENETICS : a source book for physicians , کتابخانه مرکزی دانشگاه علوم پزشکی ایران
Distributed neurochemical sensing: in vitro experiments (2003)

Experimental results characterizing a very-large scale integration (VLSI) potentiostat sensor system for recording distributed neurotransmitter activity are presented. Neurotransmitter concentration is electrochemically transduced using an array of carbon electrodes. The resultant currents are then processed in parallel by eight integrated potentiostat channels consisting of a current amplification stage, current-mode delta-sigma A/D converter, and counting decimator. Electrical characterization has shown that the VLSI potentiostat is sensitive to picoampere levels of input current. Furthermore, both static and dynamic neurochemical measurements of dopamine are verified in vitro, proving the utility of the device for brain slice studies. Lastly, a biologically inspired experiment, whereby the catabolism of dopamine is mimicked with the addition of the COMT enzyme to modulate dopamine levels in vitro.
Introduction of Perfluoroalkyl Substituents into Heteroarenes via Nucleophilic Substitution of Hydrogen (2008)

Abstract A summary of research in the area of fluoroalkylation of electron-deficient aromatic compounds is presented. The reaction of dinitro- and cyanonitroarenes with trifluoromethyl-trimethylsilane (Me 3 SiCF 3 ) and tris(dimethylamino)sulfonium difluorotrimethylsilicate (TASF) and subsequently with DMD provides trifluoromethylated cyano- and nitrophenols via oxidative nucleophilic substitution of hydrogen. Addition of fluorinated carbanions, generated either by addition of F− anions to hexafluoropropene or by activation of Me 3 SiCF 3 , to N-alkylazinium salts leads to dihydropyridines, dihydroquinolines etc., oxidation of which affords the respective fluoroalkylated heterocycles. 1,3-Dipolar cycloaddition of azine N-oxides to hexafluoropropene gives 2-heteroaryl-2,3,3,3-tetrafluoropropionic acid fluorides, which react with various protic nucleophiles to give esters and amides of 2-heteroarylperfluoropropionic acids, whereas reaction with water and decarboxylation of the free acids gives azines with a 1,2,2,2-tetrafluoroethyl group at C-2.
Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels (2005)

Synovial cell infiltration and proinflammatory cytokine expression were affected in a multifaceted manner by IA GC treatment. Marked reduction of synovial T lymphocytes, TNF, IL-1beta, extranuclear HMGB-1, ICAM-1, and VEGF occurred in association with beneficial clinical effects. Unexpectedly, macrophage infiltration and proinflammatory endothelial cytokine expression remained unchanged. These findings may reflect mechanisms controlling the transiency of clinical improvement frequently observed after IA GC injection.
Tetrahedral mixed-metal clusters containing bridging sulfido ligands. Synthesis and crystal and molecular structures of PtOs3(CO)8(PMe2Ph)3(.mu.3-S) and Os3W(CO)11(PMe2Ph)2(.mu.3-S) (1984)

The new tetrahedral mixed-metal cluster compounds PtOs3(CO)8(PMe2Ph)3(μ 3-S) (2) and Os3W-(CO)11(PMe2Ph)2(μ 3-S) (4) have been prepared by the reaction of Os3(CO)10(μ3-S) (1) with Pt(PMe2Ph)4 upon mixing at room temperature and with W(CO)5(PMe2Ph) in the presence of UV irradiation in yields of 26% and 27%, respectively, and have been characterized by single-crystal X-ray diffraction methods. © 1984 American Chemical Society.
Detection of circulating neoplastic cells by reverse-transcriptase polymerase chain reaction in malignant melanoma: association with clinical stage and prognosis. (1996)

The detection of circulating melanoma cells in peripheral blood by RT-PCR correlated with the clinical stage of patients with melanoma and was an independent prognostic factor for recurrence. Further studies are warranted to better assess the significance of this test in the evaluation of prognosis, early detection of relapse, and in monitoring the effectiveness of systemic therapy.
Electrical impedance tomography of the 1995 OGI perchloroethelyne release (1996)

Goal is to determine if electrical impedance tomography (EIT) might be useful to map free product DNAPL (dense nonaqueous phase liquids) contamination. EIT was used to image the plume resulting from a release of 189 liters (50 gallons) of perchloroethylene (PCE) into a saturated aquifer constructed of sand with two layers of bentonite. Images were made in 4 planes, before, during, and after the release, to generate a detailed picture of the spatial and temporal development of the plume. Information of the EI (both in phase and out of phase voltages) was used at several different frequencies to produce images. Some frequency dispersion was observed in the images before and after the PCE release. Laboratory measurements of organic contamination in soil indicate detectable dispersion. A search for this effect in EIT images reveals weak evidence, the signal appearing just above the measurement uncertainty, of a change in the reactance in the soil because of the PCE.
A critical analysis of the α, β and γ phases in poly(vinylidene fluoride) using FTIR (2017)

A universal but simple procedure for identifying the α, β and γ phases in PVDF using FTIR is proposed and validated. An integrated quantification methodology for individual β and γ phase in mixed systems is also proposed.
Successful Management of Sequential Pulmonary Infections in a Cardiac Transplant Recipient (1990)

A case of a cardiac allograft recipient who had an initial combined pulmonary infection with cytomegalovirus, Aspergillus fumigatus and Nocardia asteroides, successfully treated with liposomal amphotericin B and sulfisoxazole and followed by an episode of respiratory syncytial virus pneumonitis, is presented. This case illustrates the role of computed tomographic imaging in the recognition, diagnosis and monitoring of complex opportunistic pulmonary infections and the benefits of liposomal amphotericin B in the treatment of aspergillosis.
Procalcitonin: a marker of heart failure (2015)

Serum procalcitonin levels, showing high sensitivity and specificity for diagnosing and assessing the severity of heart failure in this small study, might be considered ootential heart failure biomarkers.
Research of the Network Information Monitoring System Based on P2DR Model (2010)

Network information monitoring technology (NIMT) is a key technology to the next generation of network defense system. The existed NIMTs mostly do not have a dynamic warning and controlling function, neither support IPv6. This paper provides a scalable network dynamic monitoring and warning system. It forms an associated dynamic security defense system based on traffic analyse, intrusion detection and statistics table. It can be connected in parallel or series with high flexibility. Proved by experimental comparisons, it can significantly increase the efficiency of data capture and network monitoring through the association of various modules.
In vitro rosetting, cytoadherence, and microagglutination properties of Plasmodium falciparum-infected erythrocytes from Gambian and Tanzanian patients (1990)

To understand the molecular mechanisms that lead to sequestration of red blood cells infected with mature stages of Plasmodium falciparum and to examine the relevance of earlier studies on adherence properties of laboratory-derived P falciparum parasites to the natural parasite population, we analyzed Gambian and Tanzanian isolates for in vitro cytoadherence and antibody-mediated microagglutination. Eighteen cryopreserved isolates of ring-stage parasites were cultured for 20 to 30 hours in vitro, in the patients original erythrocytes, to the trophozoite and schizont stage. All parasites were positive in the microagglutination assay with at least one of four African hyperimmune sera. In a rosetting assay, only 2 of the 18 isolates were strongly positive (35% and 41% of parasitized erythrocytes with more than two uninfected cells bound). Thirteen isolates showed either intermediate (5% to 18%) or low (less than 5%) rosetting while three isolates did not form rosettes. Infected cell-binding of the different isolates to immobilized CD36 or thrombospondin, or C32 melanoma cells correlated with the percentage of mature parasites in the blood samples (r = .932 for CD36, r = .946 for thrombospondin, and r = .881 for C32 melanoma cells). There was a high correlation between binding to CD36 and thrombospondin (r = .982). The extent of infected cell rosetting with uninfected cells in these blood samples was not correlated with these other receptor properties. We also observed coexpression of rosetting and cytoadherence receptors on the same parasitized erythrocytes.
Citrate Fermentation by Lactococcus and Leuconostoc spp (1991)

Citrate and lactose fermentation are subject to the same metabolic regulation. In both processes, pyruvate is the key intermediate. Lactococcus lactis subsp. lactis biovar diacetylactis homofermentatively converted pyruvate to lactate at high dilution (growth) rates, low pH, and high lactose concentrations. Mixed-acid fermentation with formate, ethanol, and acetate as products was observed under conditions of lactose limitation in continuous culture at pH values above 6.0. An acetoin/butanediol fermentation with alpha-acetolactate as an intermediate was found upon mild aeration in continuous culture and under conditions of excess pyruvate production from citrate. Leuconostoc spp. showed a limited metabolic flexibility. A typical heterofermentative conversion of lactose was observed under all conditions in both continuous and batch cultures. The pyruvate produced from either lactose or citrate was converted to d-lactate. Citrate utilization was pH dependent in both L. lactis and Leuconostoc spp., with maximum rates observed between pH 5.5 and 6.0. The maximum specific growth rate was slightly stimulated by citrate, in L. lactis and greatly stimulated by citrate in Leuconostoc spp., and the conversion of citrate resulted in increased growth yields on lactose for both L. lactis and Leuconostoc spp. This indicates that energy is conserved during the metabolism of citrate.
Low Noise Microwave Receivers for Radio Application (1981)

After a survey on "image recovery" microwave mixers, the paper presents a complete line from 2 to 11 GHz of new low noise wide-band microwave receivers using field effect transistor preamplifier. Design criteria and achieved performances are shown.
Active Online Anomaly Detection Using Dirichlet Process Mixture Model and Gaussian Process Classification (2017)

We present a novel anomaly detection (AD) system for streaming videos. Different from prior methods that rely on unsupervised learning of clip representations, that are usually coarse in nature, and batch-mode learning, we propose the combination of two non-parametric models for our task: (i) Dirichlet process mixture models (DPMM) based modeling of object motion and directions in each cell, and (ii) Gaussian process based active learning paradigm involving labeling by a domain expert. Whereas conventional clip representation methods adopt quantizing only motion directions leading to a lossy, coarse representation that are inadequate, our clip representation approach results in fine grained clusters at each cell that model the scene activities (both direction and speed) more effectively. For active anomaly detection, we adapt a Gaussian Process framework to process incoming samples (video snippets) sequentially, seek labels for confusing or informative samples and and update the AD model online. Furthermore, the proposed video representation along with a novel query criterion to select informative samples for labeling that incorporates both exploration and exploitation criteria is proposed, and is found to outperform competing criteria on two challenging traffic scene datasets.
Methods of Detecting and Locating Tubing and Packer Leaks in the Western Operating Area of the Prudhoe Bay Field (1995)

Summary Evaluation methods have been developed to detect cases of tubing/ annulus communication. Temperature, spinner and noise logs, as well as fluid level detection equipment, are used under a variety of flow conditions. Step-wise procedures are provided.
The effect of Ru catalyst for Li-CO₂ batteries (2022)

본 논문에서 LATP 고체 전해질을 사용하고 Ru 촉매를 적용한 SuperP 양극으로 사용하고 리튬 메탈을 음극으로 사용한 Li-CO₂ 전지 제조 및 특성평가를 통해 Ru 촉매의 효과에 대해 논의한다. Ru 촉매를 적용했을 때 분극 전압의 크기가 약 3.4 V에서 1.3 V로 현저하게 감소하였다. Ru 촉매의 적용은 분극의 크기를 줄여 배터리의 전기화학반응의 저항을 줄이고 Li-CO₂ 전지의 안정성을 높이는 역할을 하였다.
Bandwidth enhancement in an InGaN/GaN three-section superluminescent diode for optical coherence tomography (2020)

In this paper, the optoelectronic properties of InGaN-based blue (430 nm) superluminescent light-emitting diodes with a multi-section, three contact design are reported. The bias conditions of the rear absorber section and gain sections are explored in terms of enhancing and maximizing spectral bandwidth. We demonstrate that broader emission can be obtained with a short circuit, rather than an open circuit absorber section, and with two active regions at different current densities as opposed to a single active contact. Under optimal drive conditions, a −3 dB linewidth of 20 nm is obtained at 430 nm. Analysis of the device emission spectrum indicates that an axial resolution of ∼3.4 μm may be obtained in an optical coherence tomography system.
Transcriptome-scale RNase-footprinting of RNA-protein complexes (2016)

Ribosome profiling is widely used to study translation in vivo, but not all sequence reads correspond to ribosome-protected RNA. Here we describe Rfoot, a computational pipeline that analyzes ribosomal profiling data and identifies native, nonribosomal RNA-protein complexes. We use Rfoot to precisely map RNase-protected regions within small nucleolar RNAs, spliceosomal RNAs, microRNAs, tRNAs, long noncoding (lnc)RNAs and 3′ untranslated regions of mRNAs in human cells. We show that RNAs of the same class can show differential complex association. Although only a subset of lncRNAs show RNase footprints, many of these have multiple footprints, and the protected regions are evolutionarily conserved, suggestive of biological functions.
Efficacy of Enfuvirtide in Patients Infected with Drug-Resistant HIV-1 in Europe and Australia (2003)

The addition of enfuvirtide to an optimized background regimen provided significant viral suppression and immunologic benefit over a 24-week period in HIV-1-infected patients who had previously received multiple antiretroviral drugs.
Compact Sub-Vt Optical Sensor for the Detection of Fault Injection in Hardware Security Applications (2019)

Optical fault injection attacks can be used to induce errors into cryptographic circuits during sensitive calculations in order to reveal the secret information inside the system. In high-end fault injection setup, the adversary may use high resolution laser to inject localized faults. Most of the existing sensors that aim to detect these kind of attacks are big in area and therefore in many cases can be easily detected. In addition, these sensors are custom designed IPs and can't be implemented using standard digital design flow. In this paper we present a very simple and compact (area of 2.3μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> in 65nm CMOS technology) digital detector that can be implemented in a distributed manner as part of the digital logic during the design flow, near sensitive locations. The proposed sensor operates in the sub-threshold region and consumes low static power of 366pW (@ V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> = 1.2V). post-Layout simulation results shows that while the sensor is 10X more sensitive than a minimum sized CMOS inverter, it is robust against false alarms.
Web Information Retrieval Support Systems: The Future of Web Search (2011)

The primary focus of Web Information Retrieval Support Systems (WIRSS) are to address the aspects of search that consider the specific needs and goals of the individuals conducting Web searches. WIRSS moves beyond the traditional focus of automated searching within digital collections, applying intelligent methods and Web-based technologies to assist users in specifying their information needs, evaluating and exploring search results, and managing the information they find. The goal of this paper is to provide an overview of some of the key issues, challenges, and opportunities in WIRSS research. 1.
Individually Addressable Thermo‐ and Redox‐Responsive Block Copolymers by Combining Anionic Polymerization and RAFT Protocols (2014)

A novel diblock copolymer consisting of poly(vinylferrocene) (PVFc) and poly(N,N-diethylacrylamide) (PDEA) is synthesized via a combination of anionic and RAFT polymerization. The use of a novel route to hydroxyl-end-functionalized metallopolymers in anionic polymerization and subsequent esterification with a RAFT agent leads to a PVFc macro-CTA (M¯n = 3800 g mol(-1) ; Đ = 1.17). RAFT polymerization with DEA affords block copolymers as evidenced by (1) H NMR spectroscopy as well as size exclusion chromatography (6400 ≤ M¯n≤ 33700 g mol(-1) ; 1.31 ≤ Đ 1.28). Self-assembly of the amphiphilic block copolymers in aqueous solution leads to micelles as shown via TEM. Importantly, the distinct thermo-responsive and redox-responsive character of the blocks is probed via dynamic light scattering and found to be individually and repeatedly addressable.
High-throughput single cell gene expression profiling of peripheral blood mononuclear cells from healthy donor and individuals with rheumatoid arthritis (2017)

Abstract Peripheral blood has been extensively studied using gene expression microarrays in the past. These studies have revealed numerous genes that are differentially expressed between diseased and healthy populations. However, almost all these studies utilized bulk RNA isolated from blood cells for analysis, therefore masking the contribution from different types of cells in the sample. Here, we demonstrated the use of high throughput single cell gene expression analysis to profile peripheral blood mononuclear cells. Using BDTM Resolve and next-gen sequencing, we studied the single cell profiles of a total of ~27,000 cells obtained from two individuals with rheumatoid arthritis (RA) and a healthy donor. By studying either the profiles of the entire transcriptome or a representative set of ~500 gene markers via targeted amplification, we were able to observe distinct expression patterns in the monocyte population in RA patients as compared to controls, as well as difference in overall population architecture. At similar or even lower sequencing cost per cell, targeted amplification of representative gene markers offers much higher resolution of gene expression analysis of highly similar subtypes of cells (such as T cells) as compared to the whole transcriptome approach. These results demonstrated that high-resolution single-cell gene expression analysis using targeted amplification can potentially be used to routinely examine peripheral blood cells in various conditions, and may serve as new screening or diagnostic approach.
Addressable discrete-line-scanning multiphoton microscopy based on a spatial light modulator (2012)

We developed a novel addressable discrete-line-scanning multiphoton microscope with high lateral and axial resolutions based on a spatial light modulator. Our discrete-line-focus design eliminates the cross talk that occurs in conventional one-dimensional line-scanning multiphoton microscopies. Additionally, a phase-only spatial light modulator is able to scan only a sample's target area by generating a specific discrete line focus according to the shape and location of the target area. Compared with other multiphoton microscopies, this technique shortens scanning time and minimizes photodamage by concentrating scanning energy and dwell time on the area of interest.
Connections between the generalized Hamilton-Lagrange and Brayton-Moser equations (1981)

Based on the concept of generalized Euler-Lagrange equations, this paper outlines a géneralized Hamilton-Lagrange formulation of RLC networks. It is shown that the generalized Lagrange equations along with a set of compatibility constraint equations represents a set of governing differential equations of order equal to the order of complexity of the network. Hamilton equations are also developed and the connection with the Brayton-Moser equations is established.
Determination of Optimal Timing Window for Pulmonary Artery MDCT Angiography (2007)

With our study protocol of a 30-second injection and 10-second saline flush, the optimal temporal window to achieve pulmonary artery enhancement greater than 200 H was from 16 seconds to 41 seconds after the start of the injection.
The effects of transoral surgery for the recurrent hypopharyngeal cancer after radiation therapy with cetuximab (2017)

目的：セツキシマブ併用放射線治療（bio-radiotherapy：BRT）後局所再発例に対する内視鏡的咽頭喉頭手術（Endoscopic laryngopharyngeal surgery：ELPS）の安全性と適応について明らかにする。対象と方法：2013年4月より2014年10月までにBRTを施行した下咽頭癌症例13例のうち，救済手術としてELPSを施行した5例を対象とし，治療成績，食事摂取の状況の検討を行った。結果：5例中1例は局所再発にて原病死，別の1例は担癌生存，残りの3例は再発なく常食摂取可能であった。局所再発例は術後の病理結果にて深部断端陽性例であった。2例に創部感染を認めたが保存的加療にて改善した。結論：BRT後の救済手術としてのELPSは病変制御と喉頭温存に有用であるがその適応を厳密に規定する必要がある。
A Novel Cyclodione Coumarin from the Stem Bark of Mesua beccariana (2011)

Our ongoing investigations on the stem bark of Mesua beccariana afforded a novel cyclodione coumarin, beccamarin, together with two known xanthones, mesuarianone, mesuasinone, two anthraquinones, 4-methoxy-1,3,5-trihydroxy-anthraquinone and 2,5-dihydroxy-1,3,4-trimethoxyanthraquinone and one coumarin, mammea A/AB. The structures were elucidated by 1D and 2D NMR and MS techniques.