gebhart/patrepeval huggingface dataset:
α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase (2012)

The primary hormone-binding surface of the insulin receptor spans one face of the N-terminal β-helix of the α-subunit (the L1 domain) and an α-helix in its C-terminal segment (αCT). Crystallographic analysis of the free ectodomain has defined a contiguous dimer-related motif in which the αCT α-helix packs against L1 β-strands 2 and 3. To relate structure to function, we exploited expanded genetic-code technology to insert photo-activatable probes at key sites in L1 and αCT. The pattern of αCT-mediated photo-cross-linking within the free and bound receptor is in accord with the crystal structure and prior mutagenesis. Surprisingly, L1 photo-probes in β-strands 2 and 3, predicted to be shielded by αCT, efficiently cross-link to insulin. Furthermore, anomalous mutations were identified on neighboring surfaces of αCT and insulin that impair hormone-dependent activation of the intracellular receptor tyrosine kinase (contained within the transmembrane β-subunit) disproportionately to their effects on insulin binding. Taken together, these results suggest that αCT, in addition to its hormone-recognition role, provides a signaling element in the mechanism of receptor activation.
Suppressed ambiguity in range by phase-coded waveforms (2002)

In Doppler radar for surveillance and remote sensing, the ambiguities in range/Doppler are usually solved by varying the pulse repetition frequency. In this paper, two alternative methods are discussed based on phase-coding and orthogonal waveforms. The first one distributes a phase code over a pulse sequence with only one phase step per pulse. The received pulses are correlated with the phase code sequence, and by varying the delay of the phase code, the subintervals in range are scanned and reflector responses outside the focused range interval become highly suppressed. The alternative method that was studied applies a set of near-orthogonal phase codes, which modulate the pulses transmitted. In the receiver, the different subintervals in range are scanned, or detected in parallel, by correlating the signal from the scene by the delayed code sequence of the pulse transmitted. Because orthogonal codes are used, a strong suppression is achieved for signals originating outside the focused subinterval in range.
Author Correction: Distribution of metallic fission-product particles in the cladding liner of spent nuclear fuel (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
THE GLOBAL VALUE CHAIN AND CHINA AUTOMOTIVE INDUSTRY UPGRADING STRATEGY (2010)

The automotive industry is often thought of as one of the most global of all industries. In the globalization era, cost competitiveness alone will not be sufficient to guarantee further success. The China’s Local Industrial Clusters（LICs）faced a serious challenge between the top-down (global) and bottom-up (local) governance pressures. This paper uses the Global Value Chain(GVC) framework analysis to explain China Automotive Industry industry’s development stage, position of the GVC, demonstrate that the relationships with these global actors and upgrading opportunities of China Automotive Industry. Key words: Global Value Chain, Automotive Industry, Upgrading Strategy
Cucumber Recombinant Inbred Lines (2002)

Release Announcement. A set of recombinant inbred (RIL) cucumber lines (Cucumis sativus L.) is being released by U. S. Department of Agriculture, Agricultural Research Service as genetic stock and for breeding purposes. These RIL were developed in conjunction with mapping experiments that sought to identify molecular markers linked to economically important traits (i.e., yield components) controlled by quantitative trait loci (QTL) in F3 families derived from a GY-7 x H-19 mating (1 and 2). These F3 families were self-pollinated to produce RIL that were assessed in two years in field tests at the University of Wisconsin Experiment Station, Hancock, WI (HES). A RIL-based map was constructed using 14 single sequence repeats (SSR), 24 sequence characterized amplified regions (SCAR), 27 amplified fragment length polymorphisms (AFLP), 62 random amplified polymorphic DNA (RAPD), 1 single nucleotide polymorphism (SNP), and 3 economically important morphological [F (gynoecy), de (determinate habit), ll (little leaf)] markers (3). This map consists of seven linkage groups spanning 706 cM with mean marker interval of 5.6 cM.. The RIL described herein can be used in conjunction this map to identify additional qualitative (e.g., disease resistance) and quantitative (e.g., fruit yield and quantity components) traits and for use in the development of inbred backcross lines for extensive genetic analyses (e.g., fine mapping).
Cloning and characterization of the groESL operon from Bacillus subtilis (1992)

The sequence of the 10 N-terminal amino acids of a Bacillus subtilis protein that cross-reacts with antibody to Escherichia coli GroEL was used to design a set of degenerate oligonucleotide probes. These probes identified a clone which carries almost the entire groESL operon from a B. subtilis subgenomic library. By chromosomal walking, an additional fragment carrying the 3' end of groESL and its flanking sequence was isolated. Sequence analysis revealed two open reading frames (ORFs) in the cloned DNA. The upstream ORF encodes a 10-kDa protein which has 47% amino acid identity with E. coli GroES. The downstream ORF encodes a 58-kDa protein which is 62% identical to E. coli GroEL. A 2.1-kb groESL mRNA from B. subtilis was detected independently by Northern (RNA) blot analyses with a groES- and a groEL-specific probe. This demonstrated that groES and groEL are in an operon. The groESL promoter was located by using a promoter-probing plasmid, and the apparent transcription start site was mapped by primer extension analysis. The same promoter is utilized under normal and heat shock conditions. This promoter has the same features as a typical sigma A promoter. A strain in which the groESL operon was under the control of the sucrose-inducible sacB promoter was created. With this strain, it was possible to show that both groES and groEL are essential genes under both normal and heat shock conditions.
Development of a coupling system for medium voltage power line communication in the CENELEC A frequency band (2016)

In this paper the performances of a new power line communication (PLC) coupling system for medium voltage (MV) smart grids are investigated in the CENELEC A frequency band (i.e. 3–95 kHz). The new coupling solution is based on the use of the capacitive divider of the voltage detecting system (VDS) as PLC coupler to the MV network. According to IEC 61243-5, VDS are worldwide used to reveal the presence of the mains voltage to ensure the safety of the operators. A proper interface circuit has been invented and patented to couple the PLC signal through the VDS. In this way no dedicated MV PLC coupler is required, thus avoiding the related costs of the coupler, of its installation, and those of the associated temporary service interruption. In this paper, a laboratory characterization of the developed coupling solution is presented in the only standardized band, CENELEC A, reserved for the Energy Utilities in Europe.
SANIERUNG VON ASPHALTSTRASSEN MIT BEWEHRUNGSEINLAGEN AUS KNOTENSTEIFEN KUNSTSTOFFGITTERN (1989)

Knotensteife Kunststoffgitter werden bei der Herstellung zweiaxial gereckt und besitzen formstabile Kreuzpunkte. Durch die Orientierung der Molekuele in den Laengs- und Querstegen sowie im Knotenbereich wird der E-Modul gesteigert und eine Dehnungsreduzierung erreicht. Dadurch verbessern diese Gitter die Asphalteigenschaften. Durch die Verankerung der Gitter mit dem Korngeruest wirken sie unabhaengig von der Klebekraft des Bitumens. Die Verformungsmoeglichkeit des Mineralgemisches wird eingeengt. Als Folge wird die Spurrinnen- und Rissbildung reduziert. Untersuchungen haben eine Gebrauchsdauerverlaengerung der Fahrbahn um den Faktor 10 bestaetigt. Die Anwendungsgebiete liegen vor allem bei der Sanierung und Verbreiterung von Strassen. Die ausgerollten Gitter werden untereinander in Laengsrichtung mit Metallklammern verbunden. Sie sind zu spannen und an der Unterlage zu befestigen. Das Aufbringen einer Verzahnungsschicht nach vorherigem Anspritzen ist erforderlich. Die Verzahnungsschicht ist befahrbar.
ImagePlus High Performance Transaction System (1990)

The need for a cost-effective method for handling, processing, storing, and retrieving transaction documents combined with the availability of hardware and software technologies capable of satisfying this need are the basis for the High Performance Transaction System discussed in this paper. The particular transactions that are the subject of this paper are bank checks, the volumes surpassing 50 billion per year and continuing to grow. Other transactions might be the handling of such documents as bill remittances, tax documents, mail-order forms, census forms, and many other similar applications. This paper discusses the system design, hardware and software architectures, and performance of the ImagePlus™ High Performance Transaction System.
A TOOL TO ASSESS BIOMECHANICAL GAIT EFFICIENCY (1996)

A goal of many physiatric interventions is to improve biomechanical walking efficiency. Thus, a tool that helps assess this efficiency, independent of cardiac, pulmonary, psychologic, or other nonbiomechanical factors, would be useful. Currently used methods to measure efficiency, including comfortable walking speed, are not specific to biomechanical variables. A potential tool, the biomechanical efficiency quotient (BEQ), which uses three variables-average stride length, vertical displacement of the trunk during walking, and sacral height during standing-is proposed and preliminarily tested. This quotient is based on Saunders, Inman, and Eberhart's theories and on a prior study in able-bodied subjects. The BEQ was computed in 20 consecutive patients with neurologically based gait disability referred for gait laboratory evaluation who subjectively reported that one or two ankle-foot-orthoses (AFOs) reduced the effort necessary to walk. The quotient was calculated with and without the AFO(s) by dividing the average vertical displacement of the sacrum, which was measured with an optoelectronic system, and by a predicted displacement, which was based on the patient's sacral height and average stride length. The mean BEQ with the AFO(s) (6.3 ± 4.4) was significantly less than the mean BEQ without the AFO(s) (9.7 ± 7.1); P = 0.005. Furthermore, the BEQ was less with the AFO(s) compared with trials without the AFO(s) in all subjects. Percent change in BEQ with the AFO(s) (26.8 ± 19.6) correlated with percent change in comfortable walking velocity (24.8 ± 31.8), r = 0.73, P < 0.001, across all subjects. The BEQ may be useful in specifically assessing the effect on biomechanical efficiency of physiatric interventions, despite variable nonbiomechanical factors. An instrument to measure vertical trunk displacement during walking outside of the gait laboratory would be extremely useful for further necessary longitudinal studies.
Ultrasonic characterization of fluid saturated absorbing polymethylacrylate porous plates. (2010)

Experiments are led on five manufactured porous polymethylmethacrylate (PMMA) samples, numbered 1–5. Their constituting materials are packed beads whose diameters run from 200–300 μm for plate 1 up to 600–700 μm for plate 5. The plates are normally insonified by wide band transducers acting within the frequency range 100–800 kHz. The samples obey Biot’s theory taking into account the viscoelasticity of the solid frame. The reflection and transmission coefficients are measured and then added or subtracted to give the two transition terms, issued from S-matrix theory. They are connected to the symmetrical or asymmetrical motions of the faces of the plates. Those terms allow us a characterization of the porous media by means of a computer program that seeks the values of the Biot parameters giving the best agreement between theory and experiments.
Professor Carl Wagner–In Memorial (1978)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation ROBERT A. RAPP; Professor Carl Wagner—In Memorial. CORROSION 1 July 1978; 34 (7): 219–225. doi: https://doi.org/10.5006/0010-9312-34.7.219 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search
A New Isoelectric Focusing Gel for Two-Dimensional Electrophoresis Constructed in Microporous Hollow Fiber Membranes (2002)

We describe the preparation of IEF tube gels inside a nonwetting microporous plastic tubing. The gel in the tube need not be extruded after the first dimension separation. Instead, the porous structure of the tubes is made wettable, and the proteins are electrophoresed "through-the-wall" into the second dimension PAGE gel. Commercial ampholytes and reagents are suitable for the procedure. A useful p/ range of 4.5-9.5 can be obtained when p/ 3-10 ampholyte mixtures are used. Because of the high surface area of the porous material, precautions must be exercised to reduce oxygen inhibition during polymerization and dehydration of the gel during storage and use. A sheath device is described that satisfies these requirements. The plastic tubes can be disposed of by incineration and pose no biohazard.
γδ T Cells and dendritic cells in refractory Lyme arthritis (2015)

Lyme disease is a multisystem infection transmitted by tick vectors with an incidence of up to 300,000 individuals/yr in the United States. The primary treatments are oral or i.v. antibiotics. Despite treatment, some individuals do not recover and have prolonged symptoms affecting multiple organs, including the nervous system and connective tissues. Inflammatory arthritis is a common symptom associated with Lyme pathology. In the past decades, γδ T cells have emerged as candidates that contribute to the transition from innate to adaptive responses. These cells are also differentially regulated within the synovia of patients affected by RLA. Here, we review and discuss potential cellular mechanisms involving γδ T cells and DCs in RLA. TLR signaling and antigen processing and presentation will be the key concepts that we review in aid of understanding the impact of γδ T cells in RLA.
ChemInform Abstract: Studies of Mild Dehydrogenations in Heterocyclic Systems. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Comparative Analysis of Nutritional Value ofOreochromis niloticus(Linnaeus), Nile Tilapia, Meat from Three Different Ecosystems (2017)

Determination of protein, lipid, and mineral content of fish meat is necessary to ensure that it meets requirements for food regulations and commercial specifications. The objective of the present study was to determine the chemical composition of Oreochromis niloticus (L.), Nile tilapia, under three different ecosystems: (1) high pollution and high density of Eichhornia crassipes , that is, water hyacinth (Lake Chivero), (2) medium pollution and medium density of water hyacinth (Lake Manyame), and (3) low pollution and low density of water hyacinth (Lake Kariba). Dry matter, protein, lipids, and ash were evaluated by proximate analysis. Minerals were determined by atomic absorption spectrophotometry and pH was determined by a pH meter. Lake Kariba fish had the highest percentage of dry matter, protein, and ash. These qualities were correlated to low levels of pollutants and high oxygen content in the harvest waters. The phosphorus content of fish from Lake Chivero was very high, in tandem with phosphate levels in the harvest waters. In addition, water from Lake Chivero had an alkaline pH, high nitrate, and low oxygen content. The results suggest that effluent from sewage works and fertilizer industries caused pollution and proliferation of water hyacinth, contributing to pervasion of the chemical composition of fish.
Accumulation of hydrogen by silicon powders in HF inductive discharge plasma (2011)

The possibility of saturation with hydrogen of micro- and nanostructured silicon powders in electrodeless plasma is demonstrated. It is established that the hydrogen concentration in the bulk of the powder is determined by the size of its particles, the hydrogen pressure in the reaction chamber, and the HF power. The mechanism of plasma saturation with hydrogen is based on the chemical interaction of hydrogen atoms and active radicals with the surface of particles of the silicon powder, which is a surface with a distorted order of stacking of silicon atoms.
Patient Priority Weighting of the Roland Morris Disability Questionnaire Does Not Change Results of the Lumbar Epidural Steroid Injections for Spinal Stenosis Trial (2016)

2.
ChemInform Abstract: High Diastereofacial Selectivity in Nucleophilic Additions to Chiral Acylsilanes. (1988)

Abstract The use of α‐chiral acylsilanes in nucleophilic addition reactions followed by protiodesilylation with the fluoride anion affords the corresponding syn alcohols in a highly stereospecific manner as is shown for the reactions of (I) with (II) and (V).
Gate Influence on the Layout Sensitivity of $ \hbox{Si}_{1 - x}\hbox{Ge}_{x}\ \hbox{S/D}$ and $\hbox{Si}_{1 - y}\hbox{C}_{y}\ \hbox{S/D}$ Transistors Including an Analytical Model (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We present a simulation study on the effect of the gate module on the channel stress in <formula formulatype="inline"><tex Notation="TeX">$\hbox{Si}_{1 - x}\hbox{Ge}_{x}$</tex></formula> and <formula formulatype="inline"><tex Notation="TeX">$\hbox{Si}_{1 - y}\hbox{C}_{y}\ \hbox{S/D}$</tex></formula> MOS transistors. Stiff gate materials, such as titanium nitride, lead to a decreased channel stress, while a replacement-gate scheme allows the increase of the effectiveness of the <formula formulatype="inline"><tex Notation="TeX">$\hbox{Si}_{1 - x}\hbox{Ge}_{x}$ </tex></formula> and <formula formulatype="inline"><tex Notation="TeX">$\hbox{Si}_{1 - y}\hbox{C}_{y}\ \hbox{S/D}$</tex></formula> techniques significantly, independent of the gate material used. The drawback of using a replacement gate is that the channel stress becomes more sensitive to layout variations. In terms of effect on <formula formulatype="inline"> <tex Notation="TeX">$\hbox{Si}_{1 - x}\hbox{Ge}_{x}/\hbox{Si}_{1 - y}\hbox{C}_{y}\ \hbox{S/D}$</tex></formula> stress generation, using a thin metal gate capped by polysilicon is similar to a full metal gate if the thin metal gate thickness exceeds 10 nm. Even metal gates as thin as 1 nm have a clear influence on the stress generation by <formula formulatype="inline"><tex Notation="TeX">$\hbox{Si}_{1 - x}\hbox{Ge}_{x}/\hbox{Si}_{1 - y}\hbox{C}_{y}\ \hbox{S/D}$</tex> </formula>. Removing and redepositing the polysilicon layer while leaving the underlying metal gate unchanged increases the stress, although not to the same extent as for complete gate removal. A simple analytical model that estimates the stress in nested short-channel <formula formulatype="inline"><tex Notation="TeX">$\hbox{Si}_{1 - x}\hbox{Ge}_{x}$ </tex></formula> and <formula formulatype="inline"><tex Notation="TeX">$\hbox{Si}_{1 - y}\hbox{C}_{y}\ \hbox{S/D}$</tex></formula> transistors is presented. This model includes the effect of germanium/carbon concentration, active-area length,</para>
ChemInform Abstract: ANTITUMOR PLANTS. 8. LYCHNOPHOLIC ACID, A NOVEL TRIOXYGENATED CARYOPHYLLENE DERIVATIVE FROM LYCHNOPHORA AFFINIS GARDN (1979)

Abstract Die natürliche Lychnopholsäure, der nichtzytotoxische Bestandteil von Lychnophora affinis, besitzt anhand der 1 H‐ und 13 C‐NMR‐Daten die Struktur (I).
In Reply (2020)

This letter to the editor remarks on additional considerations for the management of febrile neutropenia during the COVID-19 pandemic, in response to the letter by Boutayeb et al.
USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages (2018)

Abstract\n \n Background\n The focus of studies on high-density lipoproteins (HDL) has shifted from HDL-cholesterol (HDL-C) to HDL function. We recently demonstrated that low USF1 expression in mice and humans associates with high plasma HDL-C and low triglyceride levels, as well as protection against obesity, insulin resistance, and atherosclerosis. Here, we studied the impact of USF1 deficiency on HDL functional capacity and macrophage atherogenic functions, including inflammation, cholesterol efflux, and cholesterol accumulation.\n \n \n Methods\n We used a congenic Usf1 deficient mice in C57Bl/6JRccHsd background and blood samples were collected to isolate HDL for structural and functional studies. Lentiviral preparations containing the USF1 silencing shRNA expression vector were used to silence USF1 in human THP-1 and Huh-7 cells. Cholesterol efflux from acetyl-LDL loaded THP-1 macrophages was measured using HDL and plasma as acceptors. Gene expression analysis from USF1 silenced peritoneal macrophages was carried out using Affymetrix protocols.\n \n \n Results\n We show that Usf1 deficiency not only increases HDL-C levels in vivo, consistent with elevated ABCA1 protein expression in hepatic cell lines, but also improves the functional capacity of HDL particles. HDL particles derived from Usf1 deficient mice remove cholesterol more efficiently from macrophages, attributed to their higher contents of phospholipids. Furthermore, silencing of USF1 in macrophages enhanced the cholesterol efflux capacity of these cells. These findings are consistent with reduced inflammatory burden of USF1 deficient macrophages, manifested by reduced secretion of pro-inflammatory cytokines MCP-1 and IL-1β and protection against inflammation-induced macrophage cholesterol accumulation in a cell-autonomous manner.\n \n \n Conclusions\n Our findings identify USF1 as a novel factor regulating HDL functionality, showing that USF1 inactivation boosts cholesterol efflux, reduces macrophage inflammation and attenuates macrophage cholesterol accumulation, linking improved macrophage cholesterol metabolism and inflammatory pathways to the antiatherogenic function of USF1 deficiency.
Synthetic approach for Brillouin optical time-domain reflectometry (2011)

In this paper, we propose a synthetic approach to improve the spatial resolution of Brillouin optical time-domain reflectometry (BOTDR). Due to the uncertainty relation between position and frequency, the spatial resolution of a conventional BOTDR system has been limited to about one meter. It is shown that this limit could be overcome by the synthetic approach. In the synthetic approach, a Brillouin spectrum is constructed by combining several spectrums obtained by BOTDR measurements with different pump lights and low-pass filters. The pump lights and low-pass filters are composed of short and long elements with phase differences. By using the synthetic Brillouin spectrum, it is possible to estimate the Brillouin frequency shift with an arbitrary spatial resolution. This property is verified by a numerical simulation.