gebhart/patrepeval huggingface dataset:
Cloning and characterization of human urocortin. (1996)

Urocortin, a new member of the CRF peptide family which also includes urotensin I and sauvagine, was recently cloned from the rat midbrain. The synthetic replicate of urocortin was found to bind with high affinity to type 1 and type 2 CRF receptors and, based upon its anatomic localization within the brain, was proposed to be a natural ligand for the type 2 CRF receptors. Using a genomic library, we have cloned the human counterpart of rat urocortin and localized it to human chromosome 2. Human and rat urocortin share 95% identity within the mature peptide region. Synthetic human urocortin binds with high affinity to CRF receptor types 1, 2 alpha, and 2 beta, stimulates cAMP accumulation from cells stably transfected with these receptors, and acts in vitro to release ACTH from dispersed rat anterior pituitary cells. In addition, the CRF-binding protein binds human urocortin with high affinity and can prevent urocortin-stimulated ACTH secretion in vitro. The inhibitory effect of the CRF-binding protein on human urocortin can be blocked by biologically inactive CRF fragments, such as CRF(9-33).
Managed Care and the Infectious Diseases Specialist (1996)

There is growing demand to contain health care costs and to reassess the value of medical services. The traditional hospital, academic, and research roles of the infectious disease (ID) specialist are threatened, yet there is an increasing need for expertise because of growing antimicrobial resistance and emerging pathogens. Opportunities exist to develop and expand services for the care of patients infected with human immunodeficiency virus and in infection control, epidemiology, outcomes research, outpatient intravenous therapy, and resource management. It is important for ID physicians to appreciate the principles involved in managed care and the areas in which ID services can be valuable. To be effective, physicians need to know about tools such as practice guidelines, physician profiling, outcomes monitoring, computerized information management, risk sharing, networking, and marketing, as well as related legal issues. With a positive attitude toward learning, application, and leadership, ID physicians can redefine their role and expand their services through managed care.
Analysis of ceramic thickness shear piezoelectric gyroscopes (1997)

Equations for linear piezoelectricity are formulated in a reference frame rotating at a constant angular velocity and are simplified by a perturbation procedure when the angular velocity of the reference frame is small. The equations thus obtained are then employed in the analysis of a rectangular ceramic plate piezoelectric gyroscope operating with thickness shear modes. Approximate analytical solutions to the equations resulted from the perturbation procedure are obtained based on Mindlin’s two-dimensional equations for a piezoelectric plate which are simplified by the thickness shear long wave approximation. Free-vibration frequencies and mode shapes, as well as the condition for double resonance, are obtained. Forced vibration is also studied which leads to a simple expression for the voltage sensitivity of the gyroscope. The analysis is approximate and qualitative mainly with the purpose of exhibiting some most basic characteristics of the gyroscope. Some of the results are compared with finite element numerical method.
Can Wireless Technology Enable New Diabetes Management Tools? (2008)

Mobile computing and communications technology embodied in the modern cell phone device can be employed to improve the lives of diabetes patients by giving them better tools for self-management. Several companies are working on the development of diabetes management tools that leverage the ubiquitous cell phone to bring self-management tools to the hand of the diabetes patient. Integration of blood glucose monitoring (BGM) technology with the cell phone platform adds a level of convenience for the person with diabetes, but, more importantly, allows BGM data to be automatically captured, logged, and processed in near real time in order to provide the diabetes patient with assistance in managing their blood glucose levels. Other automatic measurements can estimate physical activity, and information regarding medication events and food intake can be captured and analyzed in order to provide the diabetes patient with continual assistance in managing their therapy and behaviors in order to improve glycemic control. The path to realization of such solutions is not, however, without obstacles.
Digital predistortion of RF amplifiers using baseband injection for mobile broadband communications (2014)

Radio frequency (RF) power amplifiers (PAs) represent the most challenging design parts of wireless transmitters. In order to be more energy efficient, PAs should operate in nonlinear region where they produce distortion that significantly degrades the quality of signal at transmitter’s output. With the aim of reducing this distortion and improve signal quality, digital predistortion (DPD) techniques are widely used. This work focuses on improving the performances of DPDs in modern, next-generation wireless transmitters. A new adaptive DPD based on an iterative injection approach is developed and experimentally verified using a 4G signal. The signal performances at transmitter output are notably improved, while the proposed DPD does not require large digital signal processing memory resources and computational complexity. Moreover, the injection-based DPD theory is extended to be applicable in concurrent dual-band wireless transmitters. A cross-modulation problem specific to concurrent dual-band transmitters is investigated in detail and novel DPD based on simultaneous injection of intermodulation and cross-modulation distortion products is proposed. In order to mitigate distortion compensation limit phenomena and memory effects in highly nonlinear RF PAs, this DPD is further extended and complete generalised DPD system for concurrent dual-band transmitters is developed. It is clearly proved in experiments that the proposed predistorter remarkably improves the in-band and out-of-band performances of both signals. Furthermore, it does not depend on frequency separation between frequency bands and has significantly lower complexity in comparison with previously reported concurrent dual-band DPDs.
Delta-Gap Source Excitation Model in Surface-Volume-Surface Electric Field Integral Equation for 3-D Interconnect Characterization (2019)

A delta-gap source model is proposed for Surface-Volume-Surface Electric Field Integral Equation (SVS-EFIE) which is a new class of single source integral equation (SSIE). The proposed excitation model enables the use of SVS-EFIE for full-wave analysis of interconnects which accurately accounts for the loss in the conductors and allows for rigorous handling of the substrate multilayered medium. The delta-gap source model of SVS-EFIE is derived based on the conventional model that was formulated for the classic surface Electric Field Integral Equation (EFIE). The computation of the network parameters, however, requires computation of the electric fields at the ports volumetric cross-sections. The SVS-EFIE and the proposed source model are discretized using Method of Moments (MoM). Preliminary numerical results are provided for current distribution and the input impedance calculations of a dipole antenna. The input impedance of the dipole antenna computed using proposed excitation model is shown to agree well with that computed using classical surface EFIE provided the latter uses appropriate surface impedance model to account for the conductor loss.
Combination of Nanomicellar Technology and In Situ Gelling Polymer as Ocular Drug Delivery System (ODDS) for Cyclosporine-A (2021)

A combination of in situ gelling systems and a loaded drug self-assembling nanomicellar carrier was chosen in this study as a new potential Ocular Drug Delivery System (ODDS) for Cyclosporine-A (CyA), a poorly water-soluble drug. Two non-ionic surfactants (d-α-tocopherol polyethylene glycol succinate, VitE-TPGS and polyoxyl 40 hydrogenated castor oil, RH-40) were used to produce the nanomicelles. The physical-chemical characterization of the nanomicelles in terms of CyA entrapment (EE%) and loading efficiency (LE%), cloud point (CP), regeneration time (RT), size and polydispersity index (PI) allowed us to select the best combination of surfactant mixture, which showed appropriate stability, high CyA-EE (99.07%), very small and homogeneous dimensions and favored the solubilization of an amount of CyA (0.144% <i>w</i>/<i>w</i>) comparable to that contained in marketed emulsion Ikervis<sup>®</sup>. The selected nanomicellar formulation incorporated into optimized ion-sensitive polymeric dispersions of gellan gum (GG-LA: 0.10, 0.15 and 0.20% <i>w</i>/<i>w</i>) able to trigger the sol-gel transition after instillation was characterized from technological (osmolality, pH, gelling capacity, rheological behavior, wettability, TEM and storage stability at 4 and 20 °C) and biopharmaceutical points of view. This new combined approach allowed us to obtain clear aqueous dispersions that were easy to instill and able to form a viscous gel when in contact with the tear fluid, improving CyA ocular bioavailability. Furthermore, this new ODDS prevented CyA transcorneal permeation, exhibited low cytotoxicity and prolonged the CyA resident time in the precorneal area compared to Ikervis<sup>®</sup>.
Changes in fluoride removal ability of chicken bone char with changes in calcination time (2019)

Abstract Changes in fluoride removal ability of chicken bone char (CBC) were investigated by both remained amounts of carbon including organic substances and crystallite size of hydroxyapatite in the CBC. Carbon contents in CBC were controlled by heating time at 600°C. Although temperature for crystal‐grain growth for HAp, 650°C, was higher than 600°C, crystallite size of HAp in CBC increased with heating time. Fluoride ion removal ability positively related to the amount of remaining carbon and negatively related to the square of crystallite size, as an index of surface area, of HAp. These results suggested that fluoride ion removal from water by CBC is not only by ion exchange and/or dissolution‐precipitation process, but also by adsorption by carbon and/or temporal capture of fluoride ion by microstructure of carbonate in CBC before immobilize it in apatite structure.
Fast all-optical random number generator (2022)

We propose a simple and all-optical method for fast random number generation based on the laser mode hopping. Through periodically restarting a two-mode laser operating in the bistable state, a random number stream can be generated due to the spontaneous emission noise. To validate the feasibility of this method, we perform a theoretical simulation using the common vertical-cavity surface-emitting laser (VCSEL) with two polarization modes. Numerical results demonstrate that fast 2.5 Gb/s random number streams can be continuously obtained with verified randomness. This scheme provide a fully monolithic solution for random number generator, due to its simple and all-optical structure.
ER Stress-Induced eIF2-alpha Phosphorylation Underlies Sensitivity of Striatal Neurons to Pathogenic Huntingtin (2014)

A hallmark of Huntington's disease is the pronounced sensitivity of striatal neurons to polyglutamine-expanded huntingtin expression. Here we show that cultured striatal cells and murine brain striatum have remarkably low levels of phosphorylation of translation initiation factor eIF2α, a stress-induced process that interferes with general protein synthesis and also induces differential translation of pro-apoptotic factors. EIF2α phosphorylation was elevated in a striatal cell line stably expressing pathogenic huntingtin, as well as in brain sections of Huntington's disease model mice. Pathogenic huntingtin caused endoplasmic reticulum (ER) stress and increased eIF2α phosphorylation by increasing the activity of PKR-like ER-localized eIF2α kinase (PERK). Importantly, striatal neurons exhibited special sensitivity to ER stress-inducing agents, which was potentiated by pathogenic huntingtin. We could strongly reduce huntingtin toxicity by inhibiting PERK. Therefore, alteration of protein homeostasis and eIF2α phosphorylation status by pathogenic huntingtin appears to be an important cause of striatal cell death. A dephosphorylated state of eIF2α has been linked to cognition, which suggests that the effect of pathogenic huntingtin might also be a source of the early cognitive impairment seen in patients.
A Channel Selection Mechanism based on Incumbent Appearance Expectation for Cognitive Networks (2009)

In this paper, we investigate stochastic multichannel load balancing in a distributed cognitive network coexisting with primary users. In particular, we propose a probabilistic technique for traffic distribution among a set of data channels by incorporating statistical information of primary users' activities in different channels into the selection process without centralized control. Moreover, the proposed scheme is enabled by a multi-channel binary exponential backoff mechanism to further facilitate contention resolution in a multi-channel environment. It is shown through simulations that the proposed MAC layer enhancement outperforms well-known multi-channel MAC protocols both in terms of aggregate end-to-end throughput and average frame end-to-end delay. Furthermore, its performance is also compared to two heuristic channel selection techniques in a multi-channel cognitive network, coexisting with incumbents.
Cell Transformation by Viruses and the Role of Viruses in Cancer: The Eleventh Marjory Stephenson Memorial Lecture (1973)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Seven degrees of separation in mobile ad hoc networks (2002)

We present an architecture that enables the sharing of information among mobile, wireless, collaborating hosts that are intermittently connected to the Internet. Participants in the system obtain data objects from Internet-connected servers, cache them and exchange them with others who are interested in them. The system exploits the fact that there is a high locality of information access within a geographic area. It aims to increase the data availability to participants with lost connectivity to the Internet. We investigate how user mobility and query patterns affect data dissemination in such an environment. We discuss the main components of the system and possible applications. Finally, we present simulation results that show that the ad hoc networks can be very effective in distributing popular information.
Varied Bulk Powder Properties of Micro-Sized API within Size Specifications as a Result of Particle Engineering Methods (2022)

Micronized particles are commonly used to improve the content uniformity (CU), dissolution performance, and bioavailability of active pharmaceutical ingredients (API). Different particle engineering routes have been developed to prepare micron-sized API in a specific size range to deliver desirable biopharmaceutical performance. However, such API particles still risk varying bulk powder properties critical to successful manufacturing of quality drug products due to different particle shapes, size distribution, and surface energetics, arising from the anisotropy of API crystals. In this work, we systematically investigated key bulk properties of 10 different batches of Odanacatib prepared through either jet milling or fast precipitation, all of which meet the particle size specification established to ensure equivalent biopharmaceutical performance. However, they exhibited significantly different powder properties, solid-state properties, dissolution, and tablet CU. Among the 10 batches, a directly precipitated sample exhibited overall best performance, considering tabletability, dissolution, and CU. This work highlights the measurable impact of processing route on API properties and the importance of selecting a suitable processing route for preparing fine particles with optimal properties and performance.
Regulation of the Streptomyces coelicolor Calcium-Dependent Antibiotic by absA , Encoding a Cluster-Linked Two-Component System (2002)

The Streptomyces coelicolor absA two-component system was initially identified through analysis of mutations in the sensor kinase absA1 that caused inhibition of all four antibiotics synthesized by this strain. Previous genetic analysis had suggested that the phosphorylated form of AbsA2 acted as a negative regulator of antibiotic biosynthesis in S. coelicolor (T. B. Anderson, P. Brian, and W. C. Champness, Mol. Microbiol. 39:553-566, 2001). Genomic sequence data subsequently provided by the Sanger Centre (Cambridge, United Kingdom) revealed that absA was located within the gene cluster for production of one of the four antibiotics, calcium-dependent antibiotic (CDA). In this paper we have identified numerous transcriptional start sites within the CDA cluster and have shown that the original antibiotic-negative mutants used to identify absA exhibit a stronger negative regulation of promoters upstream of the proposed CDA biosynthetic genes than of promoters in the clusters responsible for production of actinorhodin and undecylprodigiosin. The same antibiotic-negative mutants also showed an increase in transcription from a promoter divergent to that of absA, upstream of a putative ABC transporter, in addition to an increase in transcription of absA itself. Interestingly, the negative regulation of the biosynthetic transcripts did not appear to be mediated by transcriptional regulation of cdaR (a gene encoding a homolog of the pathway-specific regulators of the act and red clusters) or by any other recognizable transcriptional regulator associated with the cluster. The role of absA in regulating the expression of the diverse antibiotic biosynthesis clusters in the genome is discussed in light of its location in the cda cluster.
Random matrix theory, the exceptional Lie groups andL-functions (2003)

There has recently been interest in relating properties of matrices drawn at random from the classical compact groups to statistical characteristics of number-theoretical L-functions. One example is the relationship conjectured to hold between the value distributions of the characteristic polynomials of such matrices and value distributions within families of L-functions. These connections are here extended to non-classical groups. We focus on an explicit example: the exceptional Lie group G_2. The value distributions for characteristic polynomials associated with the 7- and 14-dimensional representations of G_2, defined with respect to the uniform invariant (Haar) measure, are calculated using two of the Macdonald constant term identities. A one parameter family of L-functions over a finite field is described whose value distribution in the limit as the size of the finite field grows is related to that of the characteristic polynomials associated with the 7-dimensional representation of G_2. The random matrix calculations extend to all exceptional Lie groups
Contribution of Serum and Cellular Semicarbazide-Sensitive Amine Oxidase to Amine Metabolism and Cardiovascular Toxicity (1998)

Semicarbazide-sensitive amine oxidase (SSAO) plays a role in the in vivo and in vitro toxicity of several environmental and endogenous amines. We investigated the role of SSAO as a component of cell culture medium (through addition of fetal calf serum (FCS)) compared to intracellular SSAO in the in vitro cytotoxicity of three amines and metabolites. Smooth muscle cells and beating cardiac myocytes were grown in 96-well plates and exposed to various concentrations and combinations of FCS in medium, amines (allylamine, AA; benzylamine, BZA; and meth-ylamine, MA), and amine metabolites (aldehydes: acrolein, benz-aldehyde, and formaldehyde; hydrogen peroxide, H2O2; ammonia, NH3). Amine and amine metabolite cytotoxicity was quantified by monitoring cell viability. SSAO activity was measured in FCS, cardiovascular cells, or rat plasma by a radioenzymatic assay using [14C]BZA. Our data show that AA and its aldehyde metabolite, acrolein, were the most toxic compounds to both cell types. However, AA toxicity was FCS-dependent in both cell types, while BZA, MA, and amine metabolite (i.e., aldehydes, H2O2, and NH3) cytotoxicity showed little FCS dependence. In these experiments, medium containing 10% FCS had a calculated amine metabolic capacity that was 30- to 50-fold that of the cultured smooth muscle cellular content in a single well of a 96-well plate. Our study demonstrates that SSAO in FCS contributes to amine metabolism and cytotoxicity to rat cardiovascular cells in vitro and how critical it is to evaluate serum for its role in mechanisms of amine toxicity in vitro and in vivo.
Explicit Attention-Enhanced Fusion for RGB-Thermal Perception Tasks (2023)

Recently, RGB-Thermal based perception has shown significant advances. Thermal information provides useful clues when visual cameras suffer from poor lighting conditions, such as low light and fog. However, how to effectively fuse RGB images and thermal data remains an open challenge. Previous works involve naive fusion strategies such as merging them at the input, concatenating multi-modality features inside models, or applying attention to each data modality. These fusion strategies are straightforward yet insufficient. In this paper, we propose a novel fusion method named Explicit Attention-Enhanced Fusion (EAEF) that fully takes advantage of each type of data. Specifically, we consider the following cases: i) both RGB data and thermal data, ii) only one of the types of data, and iii) none of them generate discriminative features. EAEF uses one branch to enhance feature extraction for i) and iii) and the other branch to remedy insufficient representations for ii). The outputs of two branches are fused to form complementary features. As a result, the proposed fusion method outperforms state-of-the-art by 1.6\% in mIoU on semantic segmentation, 3.1\% in MAE on salient object detection, 2.3\% in mAP on object detection, and 8.1\% in MAE on crowd counting. The code is available at https://github.com/FreeformRobotics/EAEFNet.
Analog Design Considerations For Independently Driven Double Gate MOSfets And Their Application in a Low-Voltage OTA (2007)

This paper explores new capabilities brought on by Independently Driven Double Gate CMOS transistors (IDGMOS) for analog baseband design. Since the gates are disconnected, the corresponding channels are coupled resulting in a dynamic threshold voltage tuning. This operation mode is exploited to create new analog functions and low-voltage circuits. A current mirror is redesigned using IDGMOS and it is shown that this structure performs an efficient differential function relating to the potentials applied to the back gates. Being adapted to low-voltage operation and self compensated from input common-mode variations, the differential current mirror is employed for the active loading of a low-voltage fully- balanced OTA. It then improves the limited common-mode rejection of the original OTA structure by providing output feed-back and input feed-forward compensation.