gebhart/patrepeval huggingface dataset:
Novel Asymmetric Slant Field Plate Technology for High-Speed Low-Dynamic Ron E/D-mode GaN HEMTs (2016)

In this letter, we discuss a novel asymmetric field plate structure utilizing a slanted field plate (FP) engineered to appropriately distribute the electric field on GaN high-electron mobility transistors (HEMTs) scaled for low-loss, high-speed power switch applications. A uniform electric field distribution achieved with the slant FP enables an optimum device design, where a low-dynamic ON-resistance (R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on,dyn</sub> ) and high breakdown voltage are obtained simultaneously by minimizing the gate-drain distance. The optimized FP design demonstrated a low R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on,dyn</sub> of 2.3 (2.1) Ω-mm at a quiescent drain voltage of 50V in E-mode (D-mode) HEMTs with a breakdown voltage of 138 V (146 V). The corresponding high-frequency performance of E-mode (D-mode) HEMTs of peak f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> /f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</sub> = 41/100 GHz (53/100 GHz) yielded a decent R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on,dyn</sub> ×Qg product in the range of 31.0-34.5 (28.0-33.3) mQ-nC. This new slant FP technology combined with scaled epitaxial structure (for short L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> ) and reduced access resistances, using n+ GaN ohmic contacts, greatly enhances performance and design flexibility of high-speed, low-loss, GaN power switch devices.
<title>Diffractive color separation fabrication</title> (1998)

At the Cockpit Displays III &amp; IV conference, diffractive color separation was proposed as a means for improving both the performance and efficiency of liquid crystal displays. This paper discusses that approach in further detail as well as the progress made in attempting to develop the necessary technology. A design for the color separator filter was made based around the use of an analog and binary fabrication technologies. Performance of the two resulting color separation filters will be discussed.
Validation of noninvasive oscillometric blood pressure 2020 up pressure upper arm blood pressure monitoring technology according to the European Society of Hypertension International Protocol revision 2010 (2019)

To validate noninvasive oscillometric blood pressure (NIBP) 2020 up pressure (UP) upper arm blood pressure (BP) monitoring technology according to the European Society of Hypertension International Protocol revision 2010 (ESH-IP revision 2010). According to the protocol, 33 participants were included. NIBP2020 UP technology was integrated into the BP+ host device, and common upper arm cuffs were used. The study included patients from ambulatory Hypertension Units. The validation procedure was performed exactly as required by ESH-IP revision 2010. Overall, 57.6% of the study population was female. Mean age was 45.5±16.3 years. Mean systolic blood pressure (SBP) was 142.9±30.6 mmHg and mean diastolic blood pressure (DBP) was 89.0±24.9 mmHg. The number of measurements within the difference range of up to 5 mmHg was 86 for SBP and 92 for DBP; 95 measurements of SBP and 99 of DBP were within the difference range of up to 10 mmHg, and 97 measurements of SBP and 99 measurement of DBP were in the difference range of up to 15 mmHg. Mean observer-test device differences were -0.2±4.6 mmHg for SBP and 0.6±3.1 mmHg for DBP. At least two observer-test differences were up to 5 mmHg for SBP in all participants and for DBP in 31 participants. All participants had at least one measurement with an observer-test difference of up to 5 mmHg for SBP and DBP. The NIBP2020 UP technology integrated into the BP+ host device using common upper arm cuffs passed the validation criteria according to the ESH-IP revision 2010.
Dynamic Deduplication Decision in a Hadoop Distributed File System (2014)

Data are generated and updated tremendously fast by users through any devices in anytime and anywhere in big data. Coping with these multiform data in real time is a heavy challenge. Hadoop distributed file system (HDFS) is designed to deal with data for building a distributed data center. HDFS uses the data duplicates to increase data reliability. However, data duplicates need a lot of extra storage space and funding in infrastructure. Using the deduplication technique can improve utilization of the storage space effectively. In this paper, we propose a dynamic deduplication decision to improve the storage utilization of a data center which uses HDFS as its file system. Our proposed system can formulate a proper deduplication strategy to sufficiently utilize the storage space under the limited storage devices. Our deduplication strategy deletes useless duplicates to increase the storage space. The experimental results show that our method can efficiently improve the storage utilization of a data center using the HDFS system.
FcCH2P(CH2OH)2: a new, reactive yet air-stable ferrocene-derived phosphine [Fc =(η-C5H5)FeC5H4] (1996)

Reaction of FcCH2NMe3+I– with an excess of P(CH2OH)3 gives the air stable ferrocenylphosphine FcCH2P(CH2OH)2, characterised by an X-ray structure determination; reactivity towards reagents such as MeI, acrylonitrile and amines allows the synthesis of a range of new ferrocene-phosphine derivatives.
Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain (2016)

Cotranslational chaperones assist in de novo folding of nascent polypeptides in all organisms. In yeast, the heterodimeric ribosome-associated complex (RAC) forms a unique chaperone triad with the Hsp70 homologue Ssb. We report the X-ray structure of full length Ssb in the ATP-bound open conformation at 2.6 Å resolution and identify a positively charged region in the α-helical lid domain (SBDα), which is present in all members of the Ssb-subfamily of Hsp70s. Mutational analysis demonstrates that this region is strictly required for ribosome binding. Crosslinking shows that Ssb binds close to the tunnel exit via contacts with both, ribosomal proteins and rRNA, and that specific contacts can be correlated with switching between the open (ATP-bound) and closed (ADP-bound) conformation. Taken together, our data reveal how Ssb dynamics on the ribosome allows for the efficient interaction with nascent chains upon RAC-mediated activation of ATP hydrolysis.
A manufacturability improvement of glass-fiber reinforced aluminum laminate by forming an effective crystallographic texture in V95 alloy sheets (2015)

Theoretical notions and formation modes of the crystallographic texture of sheets made of the V95pch aluminum alloy, which intensifies the formation of parts made of glass-fiber reinforced aluminum laminates by stretch forming, are presented. The deformation texture (orientations S and Bs) is formed during hot rolling; it becomes stronger during further cold rolling. The recrystallization texture is formed during annealing (orientations [011]〈100〉, [023]〈100〉). An increase in the limiting stretch-forming coefficient after cold rolling is provided by two-stage annealing, which includes rapid heating at the continuous heat treatment line and subsequent complete annealing in an in-and-out furnace with slow cooling.
Glucose-Lowering Effects of Sulfasalazine in Type 2 Diabetes (2005)

Salicylates are therapeutic agents clinically useful in treating inflammatory bowel diseases and arthropathies. These drugs have also demonstrated glucose-lowering effects in type 2 diabetes (1–2). Sulfasalazine (SSZ) is a compound that is cleaved in vivo to 5-aminosalicylic acid (a salicylate) and sulfapyridine (a sulfonamide antibiotic). We report a case of a patient with systemic lupus erythematosus (SLE) and type 2 diabetes on high-dose insulin therapy, who after initiating SSZ experienced recurrent severe hypoglycemia and eventually achieved normoglycemia without the need for diabetes medications. After caring for the index patient, and then two others manifesting similar metabolic responses to SSZ, we conducted a systematic chart review to evaluate glycemic effects of SSZ in a cohort of diabetic patients.

A 37-year-old woman with SLE, iron-deficiency anemia, metamphetamine usage, and a 1-year history of type 2 diabetes was referred to the Santa Clara Valley Medical Center (SCVMC) diabetes clinic for treatment of severe hyperglycemia. She took 100 units of insulin daily (NPH 35 units b.i.d., regular 10 units t.i.d.), yet her self-monitored blood glucose (SMBG) values consistently exceeded 16.7 mmol/l, and she experienced polyuria/dipsia and blurry vision. Other medications were prednisone 7.5 mg/day and hydroxychloroquine. On examination, the patient was cachexic, weighing 44 kg. Laboratory evaluation revealed normal …
Influences of Desmin and Keratin 19 on Passive Biomechanical Properties of Mouse Skeletal Muscle (2012)

In skeletal muscle fibers, forces must be transmitted between the plasma membrane and the intracellular contractile lattice, and within this lattice between adjacent myofibrils. Based on their prevalence, biomechanical properties and localization, desmin and keratin intermediate filaments (IFs) are likely to participate in structural connectivity and force transmission. We examined the passive load-bearing response of single fibers from the extensor digitorum longus (EDL) muscles of young (3 months) and aged (10 months) wild-type, desmin-null, K19-null, and desmin/K19 double-null mice. Though fibers are more compliant in all mutant genotypes compared to wild-type, the structural response of each genotype is distinct, suggesting multiple mechanisms by which desmin and keratin influence the biomechanical properties of myofibers. This work provides additional insight into the influences of IFs on structure-function relationships in skeletal muscle. It may also have implications for understanding the progression of desminopathies and other IF-related myopathies.
Kinetic study of the dehydrochlorinations of 2,2-diaryl-1,1,1-trichloroethanes by ammonia and methylamine (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetic study of the dehydrochlorinations of 2,2-diaryl-1,1,1-trichloroethanes by ammonia and methylamineMichael R. MacLaury and Anthony SaracinoCite this: J. Org. Chem. 1979, 44, 19, 3344–3347Publication Date (Print):September 1, 1979Publication History Published online1 May 2002Published inissue 1 September 1979https://pubs.acs.org/doi/10.1021/jo01333a015https://doi.org/10.1021/jo01333a015research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Epidural Spinal Cord Stimulation Improves Locomotor Performance in Low ASIA C, Wheelchair-Dependent, Spinal Cord-Injured Individuals: Insights from Metabolic Response (2005)

Epidural spinal cord stimulation (ESCS) may be a useful tool for the recovery of locomotor function in individuals with spinal cord injury (SCI). In this article, the history of its use is briefly summarized. Results from a novel intervention combining ESCS and partial weight-bearing therapy in 2 persons with ASIA C incomplete SCI are discussed. Specifically, each person was able to walk faster and further with stimulation than without stimulation. Specific changes in muscle metabolism corresponded to the changes in locomotor performance. Most important, each person was independent with home and community ambulation (with a walker) at the end of the training period.
Analysis of the expression of the hybrid gene bcl-2/IgH in follicular lymphomas (1993)

To investigate the clinical and biologic significance of the circulating t(14;18)-carrying cells in follicular lymphoma (FL) patients, we analyzed the mbr/JH junction of the hybrid bcl-2/IgH gene simultaneously at the DNA and RNA levels by polymerase chain reaction (PCR) in 37 peripheral blood samples from 37 patients in different remission status: 4 before treatment, 8 during treatment, and 25 in complete remission (CR). Of these 37 patients, 22 were positive either at the DNA or RNA level (8 with active disease and 14 in CR). Among these positive patients, RNA was more often negative for patients in CR (9 of 14 [64%]) than for patients with active disease (2 of 8 [25%]; Fisher's exact test, P = .09). Among the 14 patients in CR with residual disease, 2 of 5 with RNA positivity relapsed, whereas 1 of 9 with RNA negativity and DNA positivity relapsed with a median follow-up after sample collection of 8 months (range, 4 to 18 months). Simultaneous analysis of the bcl-2/IgH gene at the DNA and RNA level showed heterogeneous patterns of PCR positivity in regards to the evaluation of the biologic activity of the t(14;18)-carrying cells. A larger study and long-term follow-up will help in determining whether the expression patterns in turn reflect the functional status of disease activity in FL patients.
Dissecting Bread Wheat Heterosis through the Integration of Agronomic and Physiological Traits (2021)

To meet the challenge of feeding almost 10 billion people by 2050, wheat yield has to double by 2050. However, over the past 20 years, yield increase has slowed down and even stagnated in the main producing countries. Following the example of maize, hybrids have been suggested as a solution to overcome yield stagnation in wheat. However, wheat heterosis is still limited and poorly understood. Gaining a better understanding of hybrid vigor holds the key to breed for better varieties. To this aim, we have developed and phenotyped for physiological and agronomic traits an incomplete factorial design consisting of 91 hybrids and their nineteen female and sixteen male parents. Monitoring the plant development with normalized difference vegetation index revealed that 89% of the hybrids including the five higher yielding hybrids had a longer grain filling phase with a delayed senescence that results in larger grain size. This average increase of 7.7% in thousand kernel weight translated to a positive mid-parent heterosis for grain yield for 86% of hybrids. In addition, hybrids displayed a positive grain protein deviation leading to a +4.7% heterosis in protein yield. These results shed light on the physiological bases underlying yield heterosis in wheat, paving new ways to breed for better wheat hybrids.
CW and pulsed performance of Tm-doped photonic crystal fiber lasers (2012)

We demonstrate single-mode, highly polarized output from a thulium-doped photonic crystal fiber (PCF) with 50 &mu;m core diameter and an ultra-large mode area &gt;1000 &mu;m<sup>2</sup>. To our knowledge, this is the largest mode area of any flexible PCF and is capable of enabling the generation of high peak powers. In a Q-switched oscillator configuration, this fiber produces peak powers as high as 8.9 kW with 435 &mu;J, 49 ns pulses, &gt;15 dB polarization extinction ratio and quasi diffraction-limited beam quality. The pulse energy was scaled to &gt;1 mJ in amplifier configuration.
Optical activity in βγ-unsaturated ketones. Part 1. Effect of the direction of the electric transition dipole moment in the aromatic group in benzobicyclo[2.2.2]octen-2-one derivatives (1977)

In methoxybenzobicyclo[2.2.2]octen-2-one derivatives, a change in the position of the methoxy-group brings about a change in the direction of the transition dipole moment without much alteration in the σ-electron distribution. We have studied the effects of the change of the direction of the local chromophore on the optical activity and analysed these by application of dynamic and static coupling mechanisms. We have concluded that the optical activity is mainly produced by [graphic omitted]–[graphic omitted] coupling and depends on the direction of the local transition moments.
Telomere Maintenance and Survival in Saccharomyces cerevisiae in the Absence of Telomerase and RAD52 (2009)

Telomeres are essential features of linear genomes that are crucial for chromosome stability. Telomeric DNA is usually replenished by telomerase. Deletion of genes encoding telomerase components leads to telomere attrition with each cycle of DNA replication, eventually causing cell senescence or death. In the Saccharomyces cerevisiae strain W303, telomerase-null populations bypass senescence and, unless EXO1 is also deleted, this survival is RAD52 dependent. Unexpectedly, we found that the S. cerevisiae strain S288C could survive the removal of RAD52 and telomerase at a low frequency without additional gene deletions. These RAD52-independent survivors were propagated stably and exhibited a telomere organization typical of recombination between telomeric DNA tracts, and in diploids behaved as a multigenic trait. The polymerase-delta subunit Pol32 was dispensable for the maintenance of RAD52-independent survivors. The incidence of this rare escape was not affected by deletion of other genes necessary for RAD52-dependent survival, but correlated with initial telomere length. If W303 strains lacking telomerase and RAD52 first underwent telomere elongation, rare colonies could then bypass senescence. We suggest that longer telomeres provide a more proficient substrate for a novel telomere maintenance mechanism that does not rely on telomerase, RAD52, or POL32.
An ω-3, but Not an ω-6 Polyunsaturated Fatty Acid Decreases Membrane Dipole Potential and Stimulates Endo-Lysosomal Escape of Penetratin (2021)

Although the largely positive intramembrane dipole potential (DP) may substantially influence the function of transmembrane proteins, its investigation is deeply hampered by the lack of measurement techniques suitable for high-throughput examination of living cells. Here, we describe a novel emission ratiometric flow cytometry method based on F66, a 3-hydroxiflavon derivative, and demonstrate that 6-ketocholestanol, cholesterol and 7-dehydrocholesterol, saturated stearic acid (SA) and ω-6 γ-linolenic acid (GLA) increase, while ω-3 α-linolenic acid (ALA) decreases the DP. These changes do not correlate with alterations in cell viability or membrane fluidity. Pretreatment with ALA counteracts, while SA or GLA enhances cholesterol-induced DP elevations. Furthermore, ALA (but not SA or GLA) increases endo-lysosomal escape of penetratin, a cell-penetrating peptide. In summary, we have developed a novel method to measure DP in large quantities of individual living cells and propose ALA as a physiological DP lowering agent facilitating cytoplasmic entry of penetratin.
Emodin reduces tumor burden by diminishing M2-like macrophages in colorectal cancer (2022)

Emodin, a natural anthraquinone, has been shown to have antitumorigenic properties and may be an effective therapy for colorectal cancer (CRC). However, its clinical development has been hampered by a poor understanding of its mechanism of action. The purpose of this study was to <i>1</i>) evaluate the efficacy of emodin in mouse models of intestinal/colorectal cancer and <i>2</i>) to examine the impact of emodin on macrophage behavior in the context of CRC. We used a genetic model of intestinal cancer (Apc<sup>Min/+</sup>) and a chemically induced model of CRC [azoxymethane/dextran sodium sulfate (AOM/DSS)]. Emodin was administered orally (40 or 80 mg/kg in AOM/DSS and 80 mg/kg in Apc<sup>Min/+</sup>) three times a week to observe its preventative effects. Emodin reduced polyp count and size in both rodent models (<i>P</i> < 0.05). We further analyzed the colon microenvironment of AOM/DSS mice and found that mice treated with emodin exhibited lower protumorigenic M2-like macrophages and a reduced ratio of M2/M1 macrophages within the colon (<i>P</i> < 0.05). Despite this, we did not detect any significant changes in M2-associated cytokines (IL10, IL4, and Tgfb1) nor M1-associated cytokines (IL6, TNFα, IL1β, and IFNγ) within excised polyps. However, there was a significant increase in NOS2 expression (M1 marker) in mice treated with 80 mg/kg emodin (<i>P</i> < 0.05). To confirm emodin's effects on macrophages, we exposed bone marrow-derived macrophages (BMDMs) to C26 colon cancer cell conditioned media. Supporting our in vivo data, emodin reduced M2-like macrophages. Overall, these data support the development of emodin as a natural compound for prevention of CRC given its ability to target protumor macrophages.<b>NEW & NOTEWORTHY</b> Our study confirms that emodin is an effective primary therapy against the onset of genetic and chemically induced sporadic colorectal cancer. We established that emodin reduces the M2-like protumorigenic macrophages in the tumor microenvironment. Furthermore, we provide evidence that emodin may be acting to antagonize the P2X7 receptor within the bone tissue and consequently decrease the activation of proinflammatory cells, which may have implications for recruitment of cells to the tumor microenvironment.
Experimental demonstration of negative refraction with 3D locally resonant acoustic metafluids (2021)

Negative refraction of acoustic waves is demonstrated through underwater experiments conducted at ultrasonic frequencies on a 3D locally resonant acoustic metafluid made of soft porous silicone-rubber micro-beads suspended in a yield-stress fluid. By measuring the refracted angle of the acoustic beam transmitted through this metafluid shaped as a prism, we determine the acoustic index to water according to Snell's law. These experimental data are then compared with an excellent agreement to calculations performed in the framework of Multiple Scattering Theory showing that the emergence of negative refraction depends on the volume fraction [Formula: see text] of the resonant micro-beads. For diluted metafluid ([Formula: see text]), only positive refraction occurs whereas negative refraction is demonstrated over a broad frequency band with concentrated metafluid ([Formula: see text]).