gebhart/patrepeval huggingface dataset:
Heterobimetallic aggregates of copper(I) with thio-tungstate and -molybdate. Cation effect in aggregation of MS4Cu4Cl4units, a crystallographic study (1991)

Reaction of [MS4]2–(M = Mo or W) with CuCl in dichloromethane or acetonitrile gives a new set of bimetallic compounds isolated with various geometries for the same 1:4:4 M:S:Cu composition. Crystals of [NBu4]2[MoS4Cu4Cl4]1a are tetragonal, space group I/m, a= 13.343(5), c= 14.113(2)Å, Z= 2, R= 0.058. The crystal structure reveals discrete [MoS4Cu4Cl4]2– anions separated in the lattice by [NBu4]+ cations. The isostructural tungsten homologue 1b was isolated and characterized: space group I/m, tetragonal, a= 13.342(4), c= 14.106(5)Å. The structure of [PPh4][NPr4][MoS4Cu4Cl4]2 consists of a dimeric aggregate: monoclinic, space group P21/n, a= 9.962(8), b= 36.951(5), c= 13.114(3)Å, β= 105.71(6)°, R= 0.056. The salt [NPr4]2[WS4Cu4Cl4]3b is polymerized through linear chains. Crystals are triclinic, space group P, a= 10.283(1), b= 13.925(1), c= 15.245(1)Å, α= 110.32(1), β= 90.64(1), γ= 102.49(1)°, Z= 2, R= 0.031. The isostructural molybdenum compound 3a was also characterized: triclinic, a= 10.275, b= 13.961, c= 15.270 Å, α= 110.57, β= 90.70, γ= 102.30°. The arrangements of the mono-, di- and poly-meric aggregates in the lattice are discussed in terms of the size of the counter anion. For compounds 1b and 3a only the cell dimensions were determined.
Scientific and Pragmatic Challenges for Bridging Education and Neuroscience (2008)

Educational neuroscience is an emerging effort to integrate neuroscience methods, particularly functional neuroimaging, with behavioral methods to address issues of learning and instruction. This article consolidates common concerns about connecting education and neuroscience. One set of concerns is scientific: in-principle differences in methods, data, theory, and philosophy. The other set of concerns is pragmatic: considerations of costs, timing, locus of control, and likely payoffs. The authors first articulate the concerns and then revisit them, reinterpreting them as potential opportunities. They also provide instances of neuroscience findings and methods that are relevant to education. The goal is to offer education researchers a window into contemporary neuroscience to prepare them to think more specifically about the prospects of educational neuroscience.
Supplemental Figures and Reagent Table from Adaptive NK Cells with Low TIGIT Expression Are Inherently Resistant to Myeloid-Derived Suppressor Cells (2023)

&lt;p&gt;Supplemental figure. 1: Gating strategy of conventional and adaptive NK cells in healthy donors and MDS patients. Supplemental figure. 2: Gating strategy for MDSC and monocytes, CD16 expression on conventional and adaptive NK cells, expression of different NK cell receptors following co-culture with monocytes or MDSC, and differential production of IFNg on TIGIT high/low NK cells. Supplemental figure. 3: Evaluation of TIGIT blocking antibodies. IFNg production following DNAM-1 and TIGIT co-blocking. NK cell TNFa production in conventional and adaptive NK cells cultured with monocytes or MDSC. Supplemental Table. 1: All antibodies used throughout the study including clone, manufactory, fluorochrome, and marker.&lt;/p&gt;
A Heterobimetallic Ga/Yb-Schiff Base Complex for Catalytic Asymmetric α-Addition of Isocyanides to Aldehydes (2009)

Development of a new heterobimetallic Ga(O-iPr)(3)/Yb(OTf)(3)/Schiff base 2d complex for catalytic asymmetric alpha-additions of isocyanides to aldehydes is described. Schiff base 2d derived from o-vanillin was suitable to utilize cationic rare earth metal triflates with good Lewis acidity in bimetallic Schiff base catalysis. The Ga(O-iPr)(3)/Yb(OTf)(3)/Schiff base 2d complex promoted asymmetric alpha-additions of alpha-isocyanoacetamides to aryl, heteroaryl, alkenyl, and alkyl aldehydes in good to excellent enantioselectivity (88-98% ee).
An Activated Germanium Metal-Promoted, Highly Diastereoselective Reformatsky Reaction (1998)

Activated germanium metal, prepared by the reduction of germanium(II) iodide with potassium metal, was found to promote the Reformatsky reaction effectively under mild conditions. In the presence of activated germanium metal, the reactions of alpha-bromo ketones 2a and 2b and alpha-bromo imides 2e and 2f with benzaldehyde (1a) proceeded smoothly to give the corresponding beta-hydroxy carbonyl compounds 3a, 3b, 3e and 3f, respectively, in good yields and with good syn diastereoselectivity. The activated germanium metal-promoted, asymmetric Reformatsky reaction of enantiomerically pure-oxazolidinone derivatives 2g-j with various aldehydes 1a-d was also examined; the highest diastereoselectivity was achieved when (1S,2R)-2-amino-1,2-diphenylethanol-derived 2j was used as the Reformatsky donor. The excellent diastereoselectivity could be explained in terms of the formation of a chairlike, six-membered transition state between the aldehyde and enolate as in the Zimmerman-Traxler model. A single recrystallization of the Reformatsky adducts, followed by hydrolysis and subsequent esterification, led to enantiomerically pure methyl 3-hydroxy-2-methylalkanoates 10j-m, with almost quantitative recovery of the enantiomerically pure 2-oxazolidinone 14.
Simulation of electronics manufacturing systems with two-card kanban (2002)

In this paper, two simulation models of an electronics manufacturing system are developed in order to evaluate the performance of kanban-based production with make-to-stock and make-to-order strategies. The first simulation model is based on the concept of make-to-stock, an approach in which a company assumes that the finished products in stock can be immediately delivered to the market. The second simulation model considers the same type of electronics manufacturing system, but the products are assumed to be make-to-order based on weekly demand. To meet the fluctuated demand, release time of raw materials and the number of kanbans can be varied to produce the desired number of finished goods. The effects of several system design parameters are studied and the difference between the make-to-stock and make-to-order strategies on the system performance is also examined.
A New Approach to the Reduction of Pump Cavitation: The Hubless Inducer (1967)

This paper describes a new and promising inducer which has no hub but a shroud. The design makes it possible to employ drastic vane sweepback. The shroud eliminates the vane clearance cavitation observed in the conventional screw inducer. Test data, cavitation photographs, and an analysis are presented. Maximum suction specific speed reached was 55,000 with 153 F water. Suction specific speed increases with speed and temperature up to a point. A special form of Reynolds number correlates the speed and temperature effect. The possible interrelation of boundary-layer transition and cavitation is discussed. Best suction specific speeds occur at positive incidence angles. The concept of incidence head is introduced and a theoretical equation is given.
Design theory and implementation for low-power segmented bus systems (2003)

The concept of bus segmentation has been proposed to minimize power consumption by reducing the switched capacitance on each bus [Chen et al. 1999]. This paper details the design theory and implementation issues of segmented bus systems. Based on a graph model and the Gomory-Hu cut-equivalent tree algorithm, a bus can be partitioned into several bus segments separated by pass transistors. Highly communicating devices are placed to adjacent bus segments, so most data communication can be achieved by switching a small portion of the bus segments. Thus, a significant amount of power consumption can be saved. It can be proved that the proposed bus partitioning method achieves an optimal solution. The concept of tree clustering is also proposed to merge bus segments for further power reduction. The design flow, which includes bus tree construction in the register-transfer level and bus segmentation cell placement and routing in the physical level, is discussed for design implementation. The technology has been applied to a μ-controller design, and simulation results by PowerMill show significant improvement in power consumption.
Abstract 2218: Whole exome DNA sequencing in human cancers of the digestive system (2010)

Abstract The onset and progression of cancer is driven by extensive rearrangement and mutation of the genome. The ever-expanding sequencing capacity ushered in by the second generation of DNA sequencers has enabled complete base-level description of the cancer genome and is therefore deepening our understanding of the etiology of the disease. We have combined a variety of approaches centered on next generation sequencing technologies aimed at comprehensive characterization of the cancer genome to define the key molecular lesions that drive tumor initiation and progression. These include targeted exonic sequencing to define coding sequence mutation, whole genome shotgun sequencing to define structural rearrangements, and cDNA sequencing to define alteration in expression levels, aberrant splicing and fusion transcripts. We have applied these approaches to pancreatic adenocarcinoma, hepatocellualr carcinoma and colorectal carcinoma. Results of genome sequencing have yielded an unprecedented picture of the rearrangements and mutations from analysis of read sequence and read coverage across the chromosomes. Evident in both the cancers is a dramatic reduction in SNP variation in the tumor genome compared to the germline from the same individual owing to extensive loss of heterozygosity. Superimposed on this are a few thousand mutations, some of which drive the tumor phenotype. The corresponding set of analog data generated by SNP-array microarray platforms provide validation of the central results from sequencing which leads to a new appreciation of the relationship between genetic change and the malignant phenotype. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2218.
Opposing regulatory roles of E2F in human telomerase reverse transcriptase (hTERT) gene expression in human tumor and normal somatic cells (2002)

Telomerase activity is closely correlated with cellular proliferative activity in human tissues. Human cells with high proliferative potential, such as tumor cells or stem cells, exhibit telomerase activity, whereas most normal human somatic cells do not. Telomerase activity is tightly regulated by the expression of its catalytic subunit human telomerase reverse transcriptase (hTERT). Through an expression cloning approach, we identified E2F-1 as a repressor of the hTERT gene in human tumor cells. Ectopic expression of E2F-1 repressed hTERT promoter activity by inhibiting Sp1 activation of the hTERT promoter. In contrast to the repressor function of E2F-1 in human tumor cells, we demonstrated that E2F-1 is an activator of the hTERT gene in normal human somatic cells. Ectopically expressed E2F-1 activated the hTERT promoter through a noncanonical DNA binding site. E2F-1, E2F-2, and E2F-3 (but not E2F-4 and E2F-5) repressed hTERT promoter activity in human tumor cells, whereas they activated it in normal somatic cells. These contrasting effects of E2F transcription factors on the hTERT promoter could underlie the paradoxical biological activities of E2F, which can both promote and inhibit cellular proliferation and tumorigenesis.
Familial pancreatic cancer: Concept, management and issues (2017)

Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome (HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (< 20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish > Caucasian) and a younger onset are common also in FPC. In European countries, "anticipation" is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (PanIN) foci, with various K-<i>ras</i> mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a <i>BRCA</i> mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990s and several surveillance projects for high-risk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society.
Boundary integral equation method in the prediction of dielectric characteristics of humidified composite insulator glass–epoxy core (2004)

This paper deals with the analysis of the influence of moisture on the dielectric properties of a composite insulator core made of epoxy resin and fibre glass, through measurements of the effective permittivity. The experiments are carried out on different core samples—dry and boiled in distilled water over different time intervals. The measured values of the complex permittivity of the core samples are discussed in the light of the results obtained by a numerical approach based on the boundary integral equation method and the PHI3D package. The comparison of the experimental and simulated results aims at finding the water content in the fibre glass.
Abstract 2739: Low-pass whole genome sequencing detects copy number variations in circulating tumor DNA (2017)

Abstract Circulating tumor DNA (ctDNA) is released from necrotic/apoptotic tumor cells into the bloodstream. Recent studies have demonstrated the value of using ctDNA as biomarkers in cancer diagnosis, prognosis, and drug resistance. Unlike local tissue biopsy, ctDNA collection and analysis is non-invasive, allows continuous monitoring of clonal evolution, and provides an overview of tumor heterogeneity. Copy number variations (CNVs) play an important role in cancer biology. However, traditional CNV analyses of ctDNA using droplet digital PCR (ddPCR) and SNP arrays can only assess a small number of genes due to the low abundance of ctDNA in the majority of patient samples. Next generation sequencing (NGS) offers a more efficient and high-throughput way to study CNVs in ctDNA. Here, we evaluated the use of low-pass whole genome sequencing (WGS) in determining CNVs in ctDNA. In this work, cell-free DNA was isolated from 1-5 ml of plasma from phase II clinical trial patients with metastatic breast cancer and non-small cell lung cancer (NSCLC) using the QIAamp Circulating Nucleic Acid Kit (QIAGEN). DNA yield was determined by ddPCR, with a range from 2-4000 ng. Sequencing libraries were prepared using 2-10 ng DNA by the ThruPLEX Plasma-Seq Kit (Rubicon Genomics). WGS at 0.1x, 0.25x, 0.5x, and 1x coverage was performed on Illumina NextSeq, and data was analyzed using Nexus Copy Number software (BioDiscovery). As a reference, we sequenced DNA from peripheral blood mononuclear cells (PBMCs) of 20 healthy donors at the same coverage. Low-pass WGS was also performed on a subset of matched tumor tissue samples as comparisons. Our results showed that WGS of ctDNA at 0.5x coverage was efficient to identify CNVs. CNVs were detected in ctDNA from about half of the patients analyzed, and in general CNVs identified in ctDNA matched the ones found in tumor tissue from the same patient. We also found that CNV patterns from different time points of the same patients clustered together. With this promising system, we will present CNV analysis in ctDNA from breast cancer and NSCLC patients enrolled in phase II clinical trials of the PI3K inhibitor pictilisib. We will evaluate the ability of the method to classify patients into different subgroups, monitor tumor progression, and identify drug resistance mechanisms. Citation Format: Xiaoji Chen, Jill M. Spoerke, Kathryn Yoh, Walter C. Darbonne, Ling-Yuh Huw, Steven Gendreau, Shih-Min A. Huang, Mark R. Lackner. Low-pass whole genome sequencing detects copy number variations in circulating tumor DNA [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2739. doi:10.1158/1538-7445.AM2017-2739
MicroRNA-101-3p suppresses cell proliferation, invasion and enhances chemotherapeutic sensitivity in salivary gland adenoid cystic carcinoma by targeting Pim-1. (2015)

MicroRNAs (miRNAs) play critical roles in carcinogenesis and tumor progression. Recent research has revealed miR-101-3p as an important regulator in several cancers. Nevertheless, its function in salivary gland Adenoid cystic carcinoma (ACC), a relatively rare malignance with poor long-term survival rate arisen in head and neck region, remain unknown. In this study, down-regulated miR-101-3p expression was detected in ACC tissues and ACC cell lines with high potential for metastasis. Ectopic expression of miR-101-3p significantly repressed the invasion, proliferation, colony formation, and formation of nude mice xenografts and induced potent apoptosis in ACC cell lines. The provirus integration site for Moloney murine leukemia virus 1 (Pim-1) oncogene was subsequently confirmed as a direct target gene of miR-101-3p in ACC. Functional restoration assays revealed that miR-101-3p inhibits cell growth and invasion by directly decreasing Pim-1 expression. Protein levels of Survivin, Cyclin D1 and β-catenin were also down-regulated by miR-101-3p. miR-101-3p enhanced the sensitivity of cisplatin in ACC cell lines. Taken together, our results demonstrate that the novel miR-101-3p/Pim-1 axis provides excellent insights into the carcinogenesis and tumor progression of ACC and may be a promising therapeutic target for this type of cancer.
Prevalence and Causes of Blindness and Low Vision Revisited after 5 years of Eye Care in Timor-Leste (2012)

Unusually for a developing country, Timor-Leste has initiated a cycle of evidence-based eye care in which, although with limitations, population data are periodically available for monitoring and planning.
Selective Emitter by Laser Doping from Phosphosilicate Glass (2009)

In the industrial fabrication of silicon solar cells, lowly doped emitters offer an opportunity to increase cell efficiency by improving blue response as well as lowering the saturation current density of the device. However, conventional approaches of metallization, like screen-printed contacts, combined with shallow emitters result in the problem of firing through the emitter and thus shunting the cell. Employing a highly doped region underneath the front contacts, a selective emitter, can avoid such shunting. Laser doping offers the possibility to tailor a diffusion profile by a simple laser process and create a selective emitter. J0E values of lowly doped emitters are presented and their impact on cell performance is shown. Two solid-state laser systems have been used to fabricate a laser doped selective emitter. Two different kinds of metallization are employed in the solar cell process and compared. The internal quantum efficiency shows an improved response in the short wavelength region. Cell efficiencies of &gt;17.7 % on 50x50 mm² cells with FF over 80 % using a shallow 120 W/sq emitter and a laser doped selective emitter have been achieved in an industrially feasible process
Decon2LS: An open-source software package for automated processing and visualization of high resolution mass spectrometry data (2009)

Decon2LS is an efficient software package for discovering and visualizing features in proteomics studies that require automated interpretation of mass spectra. Besides being easy to use, fast, and reliable, Decon2LS is also open-source, which allows developers in the proteomics and bioinformatics communities to reuse and refine the algorithms to meet individual needs.Decon2LS source code, installer, and tutorials may be downloaded free of charge at http://http:/ncrr.pnl.gov/software/.
The Detection Thresholds of Resonances at Low Frequencies (1997)

New experimental data on the detection thresholds of low-frequency resonances and antiresonances are presented. Using an adaptive procedure known as the up-down transformed response (UDTR) rule, the 70.7% detection thresholds were measured for a single added resonance (peak and notch) for different Q values and center frequencies. The signals included pink noise and pulses auditioned through earphones. The results show that detection thresholds are affected in complicated ways by Q, center frequency, and signal type. This makes their detection difficult to predict using current hearing models and frequency response measurements.
ChemInform Abstract: Synthesis and Characterization of Halogenated Amorphous Silicon via a Novel Glow Discharge Process. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Delay estimation for technology independent synthesis (2002)

This paper proposes path mapping, a method of delay estimation for technology independent combinational circuits. Path mapping provides fast and accurate delay estimation using the common ideas of tree covering technology mapping. First, path mapping performs technology mapping for all paths in the circuit with minimum delay. Then, it finds the most critical path among all the paths in the circuit. Finally, it answers its path delay as the circuit delay. Experimental results show path mapping estimates more accurate circuit delay than unit delay, and runs much faster than the technology mapper.
Monitoring and WCET analysis in COTS multi-core-SoC-based mixed-criticality systems (2014)

The performance and power efficiency of multi-core processors are attractive features for safety-critical applications, for example in avionics. But the inherent use of shared resources complicates timing analysability. In this paper we discuss a novel approach to compute the Worst-Case Execution Time (WCET) of multiple hard real-time applications scheduled on a Commercial Off-The-Shelf (COTS) multi-core processor. The analysis is closely coupled with mechanisms for temporal partitioning as, for instance, required in ARINC 653-based systems. Based on a discussion of the challenges for temporal partitioning and timing analysis in multi-core systems, we deduce a generic architecture model. Considering the requirements for re-usability and incremental development and certification, we use this model to describe our integrated analysis approach.