gebhart/patrepeval huggingface dataset:
Whole genotype constellation of prototype feline rotavirus strains FRV-1 and FRV64 and their phylogenetic relationships with feline-like human rotavirus strains (2014)

Feline rotaviruses, members of the species Rotavirus A, are an infrequent source of zoonotic infections, and were previously shown by RNA-RNA hybridization assays to possess two distinct genomic RNA constellations, represented by strains FRV-1 and FRV64. Due to the lack of whole genome sequence information for FRV-1, human rotavirus strain AU-1 has been used as a surrogate for the genotype constellation of feline rotaviruses. The aim of this study was to determine the whole genome sequence of FRV-1 and FRV64 to help understand the genetic relationships among existing feline rotaviruses from the evolutionary perspective. The genotype constellations of FRV-1 and FRV64 were G3-P[9]-I3-R3-C3-M3-A3-N3-T3-E3-H3 and G3-P[3]-I3-R3-C2-M3-A9-N2-T3-E3-H6, respectively. FRV-1 has a genotype constellation identical to that of the AU-1 strain. Although for individual genes they shared lineages, with the exception of genes encoding VP2, VP6 and VP7, the sequence identity between FRV-1 and AU-1 was considered to be sufficiently high for the AU-1 to be regarded as an example of the direct transmission of a feline rotavirus to a child. On the other hand, the FRV64 strain was not only similar in all the 11 genome segments to another feline rotavirus strain, Cat97, but also to canine rotavirus strains (K9 and CU-1) and feline/canine-like human rotavirus strains (Ro1845 and HCR3A). In conclusion, this study revealed intermingled sharing of genotypes and lineages among feline rotaviruses, suggesting the occurrence of frequent reassortment events over the course of evolution to emerge in four genotype constellations represented by FRV-1, FRV64/Cat97, Cat2 and BA222 strains.
Poly/sup 2/ paradigm: a secure network service architecture (2004)

General-purpose operating systems provide a rich computing environment both to the user and the attacker. The declining cost of hardware and the growing security concerns of software necessitate a revalidation of the many assumptions made in network service architectures. Enforcing sound design principles while retaining usability and flexibility is key to practical security. Poly/sup 2/ is an approach to build a hardened framework for network services from commodity hardware and software. Guided by well-known security design principles such as least common mechanism and economy of mechanism, and driven by goals such as psychological acceptability and immediate usability, Poly/sup 2/ provides a secure platform for network services. It also serves as a testbed for several security-related research areas such as intrusion detection, forensics, and high availability. This paper discusses the overall design and philosophy of Poly/sup 2/, presents an initial implementation, and outlines future work.
Printable electronics: towards materials development and device fabrication (2011)

Purpose There has been increasing interest in the development of printable electronics to meet the growing demand for low‐cost, large‐area, miniaturized, flexible and lightweight devices. The purpose of this paper is to discuss the electronic applications of novel printable materials. Design/methodology/approach The paper addresses the utilization of polymer nanocomposites as it relates to printable and flexible technology for electronic packaging. Printable technology such as screen‐printing, ink‐jet printing, and microcontact printing provides a fully additive, non‐contacting deposition method that is suitable for flexible production. Findings A variety of printable nanomaterials for electronic packaging have been developed. This includes nanocapacitors and resistors as embedded passives, nanolaser materials, optical materials, etc. Materials can provide high‐capacitance densities, ranging from 5 to 25 nF/in 2 , depending on composition, particle size, and film thickness. The electrical properties of capacitors fabricated from BaTiO 3 ‐epoxy nanocomposites showed a stable dielectric constant and low loss over a frequency range from 1 to 1,000 MHz. A variety of printable discrete resistors with different sheet resistances, ranging from ohm to Mohm, processed on large panels (19.5×24 inches) have been fabricated. Low‐resistivity materials, with volume resistivity in the range of 10 −4 ‐10 −6 ohm cm, depending on composition, particle size, and loading, can be used as conductive joints for high‐frequency and high‐density interconnect applications. Thermosetting polymers modified with ceramics or organics can produce low k and lower loss dielectrics. Reliability of the materials was ascertained by (Infrared; IR‐reflow), thermal cycling, pressure cooker test (PCT) and solder shock testing. The change in capacitance after 3× IR‐reflow and after 1,000 cycles of deep thermal cycling between −55°C and +125°C was within 5 per cent. Most of the materials in the test vehicle were stable after IR‐reflow, PCT, and solder shock. Research limitations/implications The electronic applications of printable, high‐performance nanocomposite materials such as adhesives (both conductive and non‐conductive), interlayer dielectrics (low‐k, low‐loss dielectrics), embedded passives (capacitors and resistors), and circuits, etc.. are discussed. Also addressed are investigations of printable optically/magnetically active nanocomposite and polymeric materials for fabrication of devices such as inductors, embedded lasers, and optical interconnects. Originality/value A thin film printable technology was developed to manufacture large‐area microelectronics with embedded passives, Z ‐interconnects and optical waveguides, etc. The overall approach lends itself to package miniaturization because multiple materials and devices can be printed in the same layer to increase functionality.
Technical note: development of a duodenal cannula for sheep1 (1992)

A single T-shaped duodenal cannula of silicone rubber with a gutter-type small inner flange was developed for sheep. The barrel of the cannula was 24 mm long with an internal diameter of 12 mm. A polyester surgical mesh (100 mm x 100 mm) was connected to the barrel of the cannula as an anchor. Fibrous tissues grew on the polyester mesh anchor and adhered firmly to the serosa of the intestine, thus leaving no gap and, hence, preventing any leakage of intestinal contents from the side of the fistula. The small (24 mm in diameter) and thin (3 mm in thickness) outer flange of the cannula became buried in the wool and prevented any mechanical disturbance of the cannula by the activity of the animal. The elasticity of the silicone rubber prevented distortion of the duodenum around the barrel of the cannula. No erosion of the tissue between the inner flange of the cannula and the mesh was seen in postmortem observations.
Transforming the bottom line: managing performance with the real numbers (1997)

Managers need to see a moving picture of organizational performance. They need to measure their quality, speed and customer service and to ensure that profitable products are sold to profitable customers. They also need to identify and encourage value creation in all their processes. These are the numbers, the critical gauges which drive the organizational machine. But traditional accounting systems can't see these numbers; it's as though they exist in a different dimension. These numbers do not flow up and down the traditional vertical management hierarchy. Rather, they flow horizontally across functional boundaries, following the chain of the organization's value-adding processes. They emphasize improvement rather than control. At their heart lies the key issue - the measurement of work - and the key question - does it add value to the customer? Between 20-30 per cent of an organization's total are represented by work for which the customer derives little or no benefit. Elimination of this work alone would immediately transform the profitability of most organizations. Measuring work is also the key to understanding the causes of costs and, thus, which products, services, customers, channels and markets are really profitable. This book shows how a horizontal information system can be designed to provide managers with the real numbers. It argues that better management information, more relevant performance measures and more thoughtful reward systems can change management behaviour, support strategy and transform the bottom line. The book's transformation agenda examines the six key imperatives: cut the workload not the workforce; focus managers and workers on the real numbers; align performance measures with strategy; sell profitable products and services; find and retain profitable customers; and implement a horizontal information system. Traditional measurement systems have become preoccupied with financial reporting and controlling budgets. But by using the real numbers to measure horizontal performance, accountants and their systems should again become the partners of managers rather than their masters. This book puts the management back into management accounting with the result of permanently transforming the bottom line.
mGluR5 mediates post-radiotherapy fatigue development in cancer patients (2018)

Cancer-related fatigue (CRF) is a common burden in cancer patients and little is known about its underlying mechanism. The primary aim of this study was to identify gene signatures predictive of post-radiotherapy fatigue in prostate cancer patients. We employed Fisher Linear Discriminant Analysis (LDA) to identify predictive genes using whole genome microarray data from 36 men with prostate cancer. Ingenuity Pathway Analysis was used to determine functional networks of the predictive genes. Functional validation was performed using a T lymphocyte cell line, Jurkat E6.1. Cells were pretreated with metabotropic glutamate receptor 5 (mGluR5) agonist (DHPG), antagonist (MPEP), or control (PBS) for 20 min before irradiation at 8 Gy in a Mark-1 γ-irradiator. NF-κB activation was assessed using a NF-κB/Jurkat/GFP Transcriptional Reporter Cell Line. LDA achieved 83.3% accuracy in predicting post-radiotherapy fatigue. "Glutamate receptor signaling" was the most significant (p = 0.0002) pathway among the predictive genes. Functional validation using Jurkat cells revealed clustering of mGluR5 receptors as well as increased regulated on activation, normal T cell expressed and secreted (RANTES) production post irradiation in cells pretreated with DHPG, whereas inhibition of mGluR5 activity with MPEP decreased RANTES concentration after irradiation. DHPG pretreatment amplified irradiation-induced NF-κB activation suggesting a role of mGluR5 in modulating T cell activation after irradiation. These results suggest that mGluR5 signaling in T cells may play a key role in the development of chronic inflammation resulting in fatigue and contribute to individual differences in immune responses to radiation. Moreover, modulating mGluR5 provides a novel therapeutic option to treat CRF.
Bite wound and mauling of a zookeeper by a gorilla (2023)

The majority of bite wounds that we encounter in the emergency department are caused by dogs, cats and humans, but bite injuries can be caused by a variety of animals. Here, we describe a case of bite wound and trauma caused by a large gorilla (Western lowland gorilla) weighing over 170 kg. Gorilla bites are rare, and the patient had an open fracture of the right distal radioulna in addition to multiple bite wounds. Treatment required careful consideration of gorilla antigenicity and a literature review to guide the selection of appropriate antimicrobial agents. Furthermore, trauma inflicted by large animals tends to require systemic traumatological screening, and patients can develop acute stress disorder because of a fear of being attacked again; therefore, early psychiatric intervention is important.
Effectiveness of a case‐based system in lesson planning (2014)

Abstract Lesson planning imposes a significant burden on teachers as they need to prepare different lesson plans for different classes according to various constraints. SmartLP , a case‐based lesson planning system, has been implemented as a means of assisting teachers in constructing quality lesson plans more quickly. SmartLP enables teachers to retrieve previous lesson plans and customise them according to their constraints as they should be tailored to accommodate differences in students, teachers and the facilities available. An evaluation study was designed to examine the effectiveness of a Case Based Reasoning ( CBR ) approach through its cycle of retrieve, reuse, revise and retain in assisting teachers in constructing lesson plans and to assess the effects, in terms of time and quality, the system had on lesson plan preparation. This paper presents the results of the study. The study revealed that all the lesson plans constructed with SmartLP took significantly less time than lesson plans constructed without. In addition, where the planning tasks had greater similarities to the cases in the case base, they took even less time to be constructed. No significant difference in the quality of the plans, measured by a scoring system, was noticed between the control and experimental groups.
A multitype contact process with frozen sites: a spatial model of allelopathy (2005)

In this paper, we introduce a generalization of the two-color multitype contact process intended to mimic a biological process called allelopathy. To be precise, we have two types of particle. Particles of each type give birth to particles of the same type, and die at rate 1. When a particle of type 1 dies, it gives way to a frozen site that blocks particles of type 2 for an exponentially distributed amount of time. Specifically, we investigate in detail the phase transitions and the duality properties of the interacting particle system.
Immune response during hantavirus diseases: implications for immunotherapies and vaccine design (2021)

Orthohantaviruses, previously named hantaviruses, cause two emerging zoonotic diseases: haemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus cardiopulmonary syndrome (HCPS) in the Americas. Overall, over 200 000 cases are registered every year worldwide, with a fatality rate ranging between 0·1% and 15% for HFRS and between 20% and 40% for HCPS. No specific treatment or vaccines have been approved by the U.S. Food and Drug Administration (FDA) to treat or prevent hantavirus-caused syndromes. Currently, little is known about the mechanisms at the basis of hantavirus-induced disease. However, it has been hypothesized that an excessive inflammatory response plays an essential role in the course of the disease. Furthermore, the contributions of the cellular immune response to either viral clearance or pathology have not been fully elucidated. This article discusses recent findings relative to the immune responses elicited to hantaviruses in subjects suffering HFRS or HCPS, highlighting the similarities and differences between these two clinical diseases. Also, we summarize the most recent data about the cellular immune response that could be important for designing new vaccines to prevent this global public health problem.
A traction stress sensor array for use in high-resolution robotic tactile imaging (2000)

A high resolution large-area array capable of resolving the three independent components of a 2D triaxial contact stress profile has been developed. The array, composed of 4096 (64/spl times/64) individual stress sensing elements, was constructed with a fully CMOS-compatible fabrication process, allowing integration of the sensing structures with digital control circuitry. The individual array elements have been shown to demonstrate linear responses to both applied normal stress (1.59 mV/kPa, 0-35 kPa) and applied shear stress (0.32 mV/kPa, 0-60 kPa). A spatial resolution comparable to the spacing of the papillary ridges of the human dermis (/spl ap/300 /spl mu/m) has been achieved within the 1.92/spl times/1.92 cm active sensing area of the array. Descriptions of the sensor structure, the required signal conditioning, and the array architecture are presented in this paper. The results of electrical and mechanical characterization studies are also outlined.
Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma (2004)

BACKGROUND: The aim of this work was to investigate in vitro the putative role of EGR-1 in the growth of glioma cells. EGR-1 expression was examined during the early passages in vitro of 17 primary cell lines grown from 3 grade III and from 14 grade IV malignant astrocytoma explants. The explanted tumors were genetically characterized at the p53, MDM2 and INK4a/ARF loci, and fibronectin expression and growth characteristics were examined. A recombinant adenovirus overexpressing EGR-1 was tested in the primary cell lines. RESULTS: Low levels of EGR-1 protein were found in all primary cultures examined, with lower values present in grade IV tumors and in cultures carrying wild-type copies of p53 gene. The levels of EGR-1 protein were significantly correlated to the amount of intracellular fibronectin, but only in tumors carrying wild-type copies of the p53 gene (R = 0,78, p = 0.0082). Duplication time, plating efficiency, colony formation in agarose, and contact inhibition were also altered in the p53 mutated tumor cultures compared to those carrying wild-type p53. Growth arrest was achieved in both types of tumor within 1-2 weeks following infection with a recombinant adenovirus overexpressing EGR-1 but not with the control adenovirus. CONCLUSIONS: Suppression of EGR-1 is a common event in gliomas and in most cases this is achieved through down-regulation of gene expression. Expression of EGR-1 by recombinant adenovirus infection almost completely abolishes the growth of tumor cells in vitro, regardless of the mutational status of the p53 gene.
An exact and direct analytical method for the design of optimally robust CNN templates (1999)

In this paper, we present an analytical design approach for the class of bipolar cellular neural networks (CNN's) which yields optimally robust template parameters. We give a rigorous definition of absolute and relative robustness and show that all well-defined CNN tasks are characterized by a finite set of linear and homogeneous inequalities. This system of inequalities can be analytically solved for the most robust template by simple matrix algebra. For the relative robustness of a task, a theoretical upper bound exists and is easily derived, whereas the absolute robustness can be arbitrarily increased by template scaling. A series of examples demonstrates the simplicity and broad applicability of the proposed method.
Supplementary Table 4 from Characterization of an Oxaliplatin Sensitivity Predictor in a Preclinical Murine Model of Colorectal Cancer (2023)

&lt;p&gt;PDF file - 47K, Corresponding class and predicted response to oxaliplatin for patient derived colorectal cancer explants.&lt;/p&gt;
TGF-beta signaling pathway: its role in gastrointestinal pathophysiology and modulation of ulcer healing. (2005)

Gastrointestinal ulcer healing is a complex process, involving cell migration, proliferation, angiogenesis and extracellular matrix deposition, all ultimately leading to reconstruction of tissue architecture within the ulcer scar. These processes are controlled by growth factors, cytokines and hormones. Transforming growth factor-beta (TGF-beta), one of the multifunctional peptide growth factors, has been reported to positively regulate gastrointestinal ulcer healing. Although TGF-beta inhibits cell proliferation in a variety of cells, it induces cell migration, angiogenesis, and enhances extracellular matrix production necessary for gastrointestinal ulcer healing. TGF-beta exerts its action by binding to its transmembrane serine/threonine kinase receptors, which in turn triggers activation of various intracellular signaling pathways. Smads are intermediate effector proteins that play key roles in biological activities of TGF-beta by transmitting the signals from the cell surface directly into the nucleus and initiating transcription. New insight into the mechanisms underlying TGF-beta-Smad modulation of gastrointestinal ulcer healing will likely enhance our understanding of the mechanisms controlling the healing processes of gastrointestinal ulcers.
Rapid changes in the microvascular circulation of skeletal muscle impair insulin delivery during sepsis (2019)

Sepsis costs the healthcare system $23 billion annually and has a mortality rate between 10 and 40%. An early indication of sepsis is the onset of hyperglycemia, which is the result of sepsis-induced insulin resistance in skeletal muscle. Previous investigations have focused on events in the myocyte (e.g., insulin signaling and glucose transport and subsequent metabolism) as the causes for this insulin-resistant state. However, the delivery of insulin to the skeletal muscle is also an important determinant of insulin action. Skeletal muscle microvascular blood flow, which delivers the insulin to the muscle, is known to be decreased during sepsis. Here we test whether the reduced capillary blood flow to skeletal muscle belies the sepsis-induced insulin resistance by reducing insulin delivery to the myocyte. We hypothesize that decreased capillary flow and consequent decrease in insulin delivery is an early event that precedes gross cardiovascular alterations seen with sepsis. This hypothesis was examined in mice treated with either lipopolysaccharide (LPS) or polymicrobial sepsis followed by intravital microscopy of the skeletal muscle microcirculation. We calculated insulin delivery to the myocyte using two independent methods and found that LPS and sepsis rapidly reduce insulin delivery to the skeletal muscle by ~50%; this was driven by decreases in capillary flow velocity and the number of perfused capillaries. Furthermore, the changes in skeletal muscle microcirculation occur before changes in both cardiac output and arterial blood pressure. These data suggest that a rapid reduction in skeletal muscle insulin delivery contributes to the induction of insulin resistance during sepsis.
Identifying Security Challenges in Renewable Energy Systems (2019)

Distributed renewable energy systems (DRESs) and their interconnection network, typically using Internet-based protocols, are susceptible to a wide range of cybersecurity and resilience challenges. These challenges have been shown to cause problems for the overall grid optimization process. In order to detect such events, we argue that an adequate correlation between network and energy generation data is required. Therefore, in this study, we provide a work-in-progress insight related to the profiling of real network data and energy generation measurements gathered by a local windturbine at Lancaster University. We argue that such an analysis is very important to profile various attack vectors in the modern energy networks that consider DRESs and take necessary actions to prevent any data breaches in the future.
Framework for Field Optimization To Maximize Asset Value (2005)

Summary In this paper, we propose an optimization framework for maximizing asset value, both with and without uncertainty. We first present the methodology to treat a general control optimization in the presence of uncertainty, followed by a brief section on the optimization algorithms used. We then describe the field model example used to illustrate the application of the methodology. Through a systematic analysis of various deterministic and stochastic cases, we address the various objectives sought. Using net present value (NPV) as a measure, we also explore the valuation of advanced completions along with the returns gained from expanding surface gas-handling facilities. The method also generates an efficient frontier that can be used for risk and decision analysis. The results clearly demonstrate the value of such a framework for value maximization in planning both near- and long-term time horizons as well as providing the necessary foundation for maximizing asset value.