gebhart/patrepeval huggingface dataset:
Intégration de systèmes hétérogènes en termes de niveaux de sécurité (2009)

This thesis studies design and implementation principles to execute tasks of different criticity levels onto the same computer. Additionally, some of these tasks may have hard real-time constraints. This requires to prove that tasks will get enough resources to execute properly, through the use of predictible and still simple allocation policies. Moreover, ensuring that critical tasks will execute correctly in presence of faults is needed. In particular, providing guarantees on resource allocation should be possible. At last, the system should be easily adaptable to different situations. This thesis tackles these issues through a design proposal for a highly secure and extensible system, which is also independent of resource allocation policies. This is accomplished in particular by systematic use of resource lending, which allows to account for resources independently of protection domains. This approach avoids partitionning resources into pools, simplifying the global allocation problem and deleting every waste of resources. We demonstrate that this approach is feasible using a prototype implementation. This methodology dramatically simplifies resource allocation, but implies additional constraints when writing shared services (e.g. device drivers). In particular, specific new synchronization problems occur. Original mechanisms to solve these problems are proposed, and a methodology that helps writing these shared services.
A User-Friendly Application to Automate CT Renal Stone Measurement (2018)

We developed a stand-alone platform with a simple easy-to-use interface, which will allow any user the ability to calculate a battery of clinically important urinary stone parameters from CT imaging at the POC. This program is now freely available online.
Hexagonal multi-beam analog RF aperture array (2014)

A spatially discrete temporally continuous antenna array analog signal processing scheme that can produce highly selective hexagonal beams is proposed. A three dimensional (3-D) infinite impulse response (IIR) filter transfer function having hexagonal beam shaped passbands in the 3-D space-time frequency domain ω is introduced. A hexagonal beam passband in ω produces a hexagonal radio beam in the array pattern, and having closely packed multiple hexagonal beams, one can optimally sense a given sky area in a typical radar/microwave imaging application. The proposed array processing scheme employs analog RF circuits for achieving scaling, summing and time delay as building blocks for the signal processing operation. The 3-D IIR filter transfer function is derived by considering an example 10th-order 1-D Butterworth prototype polynomial.
DRIVE PROJECT V1004 (DREAM). THE FEASIBILITY OF DEVELOPING A DEVICE FOR MONITORING DRIVER STATUS (1990)

The DRIVE Project V1004 is concerned with the possibility of monitoring unobtrusively driver status. In order to ensure that measures to be incorporated in DREAM (Driver Related Evaluation And Monitoring) are appropriate, all measures available are examined. The study has two main components: an assessment of the state of the art, and the use of experiments by a number of participating institutes to demonstrate the effectiveness of the various techniques currently employed. It is possible to determine what future work may be required for the development of performance measures and sensors for incorporation in a vehicle mounted monitoring device. The report gives a detailed description of the work involved in the proposed development and the means to construct the device itself. Some of the potential problems are discussed and their solution. The importance of DREAM for the road transport informatics environment is discussed. It is proposed that the device should operate using a neural network with the capability of being able to handle the numerous signals adaptively and in real time.
Supplementary Data from An RNA Aptamer–Based Biomarker Platform Demonstrates High Soluble CD25 Occupancy by IL2 in the Serum of Follicular Lymphoma Patients (2023)

&lt;p&gt;Contains Supplementary Figures, Supplementary Methods and Supplementary Tables&lt;/p&gt;
ChemInform Abstract: The Detoxin Complex. A Naturally Occurring Safener (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lenalidomide maintenance following high‐dose therapy and autologous haematopoietic stem cell transplantation in chemo‐resistant or high‐risk non‐Hodgkin lymphoma: A phase I/II study (2023)

Improved maintenance treatments are needed for patients with relapsed/refractory aggressive lymphomas after autologous haematopoietic stem cell transplantation (ASCT). Several studies with lenalidomide have been found to have activity in the treatment of relapsed/refractory aggressive lymphomas. In the present phase I/II, single-arm, open-label study, 59 patients with high-risk relapsed non-Hodgkin lymphoma received pretransplant BEAM chemotherapy and ASCT followed by 12 months of maintenance lenalidomide once daily on Days 1-21 (28-day cycles) beginning at post-transplantation Day 100. The most common histologies were mantle cell lymphoma (56%) and diffuse large B-cell lymphoma (24%). The maximum tolerated dose in the dose-finding part of the study was 15 mg, but cytopenias led to the subsequent adoption of a 10 mg dose in the final study. Sixteen patients (27%) completed 12 cycles of lenalidomide maintenance. The most common reason for discontinuation was adverse events (31%). These were primarily haematologic, and 56% of patients experienced Grade 3-4 events. Two-year PFS rates (95% CIs) were 70% (56%-80%), 45% (19%-68%) and 81% (66%-90%); 2-year OS rates (95% CIs) were 91% (80%-96%), 93% (61%-99%) and 90% (76%-96%) in all patients, patients completing and patients not completing 12-month maintenance respectively. These results do not support the use of lenalidomide maintenance in this setting.
Delusional Denial of Pregnancy as a Special Form of Cotard’s Syndrome (2006)

The following case report describes a pregnant woman who was convinced that her pregnancy was non-existent despite being in an advanced stage of clinically obvious pregnancy. The nosologically unspecific syndrome of denial of pregnancy is discussed by reviewing the literature. Based on the existing literature it will be explained why this specific syndrome is considered to indicate a special form of Cotard's syndrome.
Sample Fractionation Using Magnetic Beads (2008)

To find protein and peptide biomarkers in a biological sample, fractionation is usually required to reduce dynamic range and sample complexity. LC is a standard way of fractionating samples. Although it has a great resolving power, it is time consuming and is less ideal for the processing of many samples in parallel. Magnetic beads (Dynabeads) offer the opportunity of manual or automated high-throughput fractionation upstream of MS or 2D-gels. With 96-384 wells available, many samples can be run in parallel with one or several different chromatography surfaces (e.g., SAX, SCX and RPC 18). Because of high sensitivity and reproducibility, Dynabeads have become a popular choice for serum peptide profiling and for the pre-selection of samples (e.g., upstream of LC-MS).
Low temperature geothermal energy applications in the Albuquerque area. Final report, July 1, 1978-August 18, 1979 (1979)

A study was made of the engineering and economic feasibility of hot water geothermal energy applications in the Albuquerque area. A generalized system design was developed and used as the basis for a series of economic case studies. Reservoir and user siting considerations were studied in light of the economic findings. Several specific potential applications were identified, including university campuses, industrial and commercial facilities, and residential buildings. Specific key technical problems relating to Albuquerque area applications were studied. These included environmental impacts, corrosion, scaling, heat losses in wells and transmission lines, heat exchangers, control systems, and system utilization and reliability. It is concluded that geothermal energy could be competitive with other energy sources for space heating and limited industrial use for moderate to large (10 million Btu/hr or more) energy using systems.
Modification of PET by Reactive Blending with Sulfonated Esters. II. Isothermal Crystallization Kinetics of PET-Ionomers (2003)

The thermal properties of PET-ionomers, obtained by reactive blending between PET and a monofunctional ester containing an ionic group (–SO3Na), were studied using DSC, and results were compared with those of nonionic PET homopolymers. The presence of ionic groups located only at the chain ends induces significant modifications in the thermal behavior: the equilibrium melting temperature increases and the crystallization rate decreases with the ionic group content; moreover, the crystalline level remains high. All of these characteristics are interpreted as due to ionic associations between the sulfonated end groups, both in solid and in molten states, that cause an apparent increment in the molecular weight of ionomers. A confirmation of this simple molecular architecture is found in the growth regime analysis: the fold-surface free-energy values of ionomers do not vary compared to those of nonionic homopolymers, indicating that chain folding is not hindered by the presence of a complex network.
Administration of IFN-α Enhances the Efficacy of a Granulocyte Macrophage Colony Stimulating Factor–Secreting Tumor Cell Vaccine (2005)

IFN-alpha is approved for the treatment of multiple cancers. Its pleiotropic properties include inhibition of proliferation and angiogenesis and induction of apoptosis. Type I IFNs also exert immunomodulatory effects, which make it an appropriate candidate to combine with cancer vaccines. The studies reported herein show that 50% of mice reject established B16 tumors following treatment with the combination of a granulocyte macrophage colony-stimulating factor-secreting tumor cell vaccine (B16.GM) and subclinical doses of recombinant murine IFN-alpha delivered at the vaccine site. Similarly, 80% of mice treated with the combination reject established B16 tumors when recombinant murine IFN-alpha is given at the challenge site, suggesting that in the latter case its antiproliferative, proapoptotic, and antiangiogenic properties may be involved in controlling tumor growth. In contrast, fewer than 10% of mice reject the tumors when either one is used as a monotherapy. Furthermore, a 30-fold increase in the frequency of melanoma-associated antigen (Trp-2 and gp100) specific T cells was observed in mice treated with the combination when compared with unvaccinated controls. These data show that IFN-alpha combined with a granulocyte macrophage colony-stimulating factor-secreting tumor cell vaccine significantly enhances vaccine potency and may represent a potential new approach for tumor immunotherapy.
Platelet gels (2013)

Platelet gels (PG) are blood‐derived biomaterials that are generally obtained through the activation of a platelet‐rich plasma or a platelet concentrate by thrombin or calcium chloride, resulting in the simultaneous conversion of fibrinogen into a fibrin gel and in the generation of a platelet releasate rich in a physiological cocktail of growth factors. To reinforce the physical strength of the fibrin network, a fibrinogen‐rich fraction – generally cryoprecipitate – can be added to the platelet fraction prior to activation, resulting in the generation of platelet fibrin glue (PFG). PG and PFG, prepared from single donations, either autologous or allogeneic, are increasingly used, alone or in combination with grafting materials, in various field of regenerative medicine where the presence of growth factors is expected to stimulate the healing of soft or hard tissues. Being obtained from human blood, they are physiological and biodegradable preparations and do not induce tissue necrosis. So far, the viral safety of most allogeneic PG and PFG relies on donors selection and donation testing, as is the case for all non‐virally inactivated blood components for transfusion. Major fields of clinical applications of PG and PFG in osseous tissue regeneration include maxillo‐facial surgery, implantology, reconstructive and plastic surgery. Platelet gels are also used for enhancing the healing of soft tissues, most particularly recalcitrant lower extremity ulcers of various aetiologies, and burns. Newer promising indications include the treatment of osteo‐arthritis and joint inflammation, and the repair of musculoskeletal tissue lesions in sports medicine. Autologous PG and PFG are mostly ‘home‐made’ single‐donor preparations prepared using medical devices. They suffer from the variability in donor characteristics and in isolation procedures of the platelet fraction. Clinical application methods are not standardized. Variability in autologous product characteristics is high, and optimal content of growth factors is unknown, confusing the analysis of product efficacy. The evidence of clinical benefits of these products based on controlled clinical studies is lacking in most indications, although many case studies do support an objective benefit in soft and probably hard tissues healing. Improvement in the standardization and formulation of PG and PFG is a mandatory step forward for improving the reliability and the predictability of clinical outcomes of these interesting blood preparations.
A Hypermedia Computer-Integrated Laser Video-Disk as a Medical Learning Workstation. (1989)

Because of the complexity of visual experience, radiology training has been restricted to few individuals since it requires intensive tutorial experience to develop image recognition expertise. Video-disc and CD-ROM image storage media make it possible for microcomputer workstations to provide learning environments substantially equivalent to conventional time-consuming tutorial methods. A “hypermedia” program on echocardiography was constructed to provide a user-controlled learning environment giving instant access to 54,000 video frames from a full spectrum of cardiac diseases. Radiology residents have successfully achieved basic level expertise in echocardiography solely through use of this module.
GOOD VISUAL OUTCOME AFTER REPAIR OF A VERY LARGE MACULAR HOLE WITH NEUROSENSORY RETINAL OPERCULUM (2014)

Very large macular holes have traditionally been considered to have a poor prognosis. Here, we demonstrate that such large holes can be repaired with good visual outcome, even in the setting of an operculum consisting of avulsed neural retina.
Effects of temperature elevation from 37 to 55°c on anaerobic treatment of sulphate rich acidified wastewaters (1992)

Abstract Acetate and propionate removals exceeded 80–90% in UASB reactors treating sulphate rich substrates at 37°C. The elevation of the temperature of the UASB reactors to 55°C by increments of 1–3°Cd‐1 resulted in the complete cessation of propionate and sulphate conversion at 48°C, and of acetate conversion at 51–53°C, respectively. The applied fast (2–4 hours) temperature increase immediately stopped all treatment efficiencies. At 55°C, the presence of high sulphate concentration stimulated the propionate removal recovery. The UASB studies and batch assays showed that acetate was converted by methane production at 37°C and by sulphate reduction at 55°C.
Abnormal cytoplasmic dyslocalisation and/or reduction of nucleophosmin protein level rarely occurs in myelodysplastic syndromes (2008)

The Nucleophosmin1 (NPM1) gene located in chromosome 5q35 is affected by chromosomal translocation, mutation and deletion in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). NPM1 haploinsufficiency reportedly causes MDS-like disorders in knockout mice. Here, we studied mRNA and protein expression in bone marrow (BM) samples from 36 patients with MDS. The NPM1 expression levels of mRNA and protein were not related to chromosome 5 abnormalities and were almost the same as those in normal BM and AML cells. However, the protein levels in AML cells with NPM1 mutations were slightly lower than in those without mutation. Immunochemical studies showed no difference in the staining intensity and subcellular localisation between MDS and normal BM cells. It was concluded that abnormal cytoplasmic localisation and/or significant reduction of NPM1 protein level rarely occurs in MDS. The increase in the number of nuclear NPM1-positive cells may be related to the progression of MDS.
Surface properties of chemically modified polyimide films (1997)

Abstract Surface modification of Kapton polyimide film (325 nm thick) by means of chromic acid and perchloric acid at different times and temperatures has been carried out. The contact angle of water decreased from 82 to 55° and the surface energy increased accordingly from 26 to 45 mJ/m2 with times of etching by chromic acid up to 45 min at 33°C. Etching at higher temperatures increased the surface energy. Chromic acid was more effective than perchloric acid. IR and XPS studies indicated multiple bonding and generation of poler groups on the surface. The peak at 1778 cm-1 due to the imide group decreased on acid etching. The O/C ratio increased and the N/C ratio decreased. The peel strength of the joint polyimide film/copper film/epoxy adhesive/aluminium sheet increased about two-fold on modification of the polyimide (PI) film at 33°C for 45 min, although the changes were marginal for the PI film/silicone rubber/PI film joint. The peel strength is a function of the time and temperature of etching. Keywords: Surface propertiespolyimide filmsadhesionsurface modificationpeel strengthXPScontact angle measurement
Mapping Quantum Chemical Dynamics Problems to Spin-Lattice Simulators (2021)

The accurate computational determination of chemical, materials, biological, and atmospheric properties has a critical impact on a wide range of health and environmental problems, but is deeply limited by the computational scaling of quantum mechanical methods. The complexity of quantum chemical studies arises from the steep algebraic scaling of electron correlation methods and the exponential scaling in studying nuclear dynamics and molecular flexibility. To date, efforts to apply quantum hardware to such quantum chemistry problems have focused primarily on electron correlation. Here, we provide a framework that allows for the solution of quantum chemical nuclear dynamics by mapping these to quantum spin-lattice simulators. Using the example case of a short-strong hydrogen-bonded system, we construct the Hamiltonian for the nuclear degrees of freedom on a single Born–Oppenheimer surface and show how it can be transformed to a generalized Ising model Hamiltonian. We then demonstrate a method to determine the local fields and spin–spin couplings needed to identically match the molecular and spin-lattice Hamiltonians. We describe a protocol to determine the on-site and intersite coupling parameters of this Ising Hamiltonian from the Born–Oppenheimer potential and nuclear kinetic energy operator. Our approach represents a paradigm shift in the methods used to study quantum nuclear dynamics, opening the possibility to solve both electronic structure and nuclear dynamics problems using quantum computing systems.
Fractional active robust control (2008)

This article deals with the reduction of structural vibrations. Two approaches are possible to tackle this problem, either a passive method with dampers, or an active method with actuators that are controlled in order to decrease or even cancel the vibrations in the structure. The second method is used here. The objective is to control the damping of uncertain plants. The proposed methodology is based on iso-damping contours and CRONE control. The iso-damping contours are defined thanks to fractional order integration in the Nichols plane and are graduated by the value of the damping factor of the closed-loop response. The CRONE control is a robust control method that also uses fractional order integration. The methodology is here applied to a multivariable plant that is an aircraft wing model made with a beam and a tank whose different levels of fillings are considered as uncertainties.
A Self-Fitting Hearing Aid (2011)

The need for reliable access to hearing health care services is growing globally, particularly in developing countries and in remotely located, underserved regions in many parts of the developed world. Individuals with hearing loss in these areas are at a significant disadvantage due to the scarcity of local hearing health care professionals and the high cost of hearing aids. Current approaches to making hearing rehabilitation services more readily available to underserved populations include teleaudiology and the provision of amplification devices outside of the traditional provider-client relationship. Both strategies require access to such resources as dedicated equipment and/or specially trained staff. Another possible strategy is a self-fitting hearing aid, a personal amplification device that is equipped with an onboard tone generator to enable user-controlled, automated, in situ audiometry; an onboard prescription to determine the initial hearing aid settings; and a trainable algorithm to enable user-controlled fine-tuning. The device is thus assembled, fitted, and managed by the user without the need for audiological or computer support. This article details the self-fitting concept and its potential application in both developing and developed countries. Potential advantages and disadvantages of such a device are discussed, and considerations for further investigations into the concept are presented. Overall, the concept is considered technologically viable with the main challenges anticipated to be development of clear, simple user instructions and a delivery model that ensures reliable supplies of instant-fit ear tips and batteries.