gebhart/patrepeval huggingface dataset:
Adhérence des réparations en béton: évaluation et facteurs d'influence (2014)

La réparation et le renforcement des structures existantes en béton comptent parmi les plus importants défis auxquels les ingénieurs civils sont confrontés aujourd’hui et qu’ils devront relever dans les années à venir. Les préoccupations actuelles concernant le développement durable favorisent la réfection au détriment de la construction neuve et ne peuvent que renforcer cette tendance. Des efforts concertés de la part des scientifiques et ingénieurs sont encore nécessaires afin d’améliorer la conception des réparations en béton et d’en assurer la qualité et la fiabilité attendues. L’un des aspects essentiels de la durabilité des réparations en béton et des revêtements ou traitements de surface est la qualité de l’adhérence entre le matériau de réparation et le béton existant. Le présent article résume les principales conclusions de travaux réalisés en collaboration en vue d’identifier les facteurs influençant l’adhérence des réparations (la rugosité, le degré de saturation et la carbonatation du substrat) et l’évaluation de celle-ci en conditions in situ (type de chargement, alignement de l’appareil). Sur la base des résultats recueillis, des recommandations concernant la préparation de la surface avant réparation ont été émises dans un guide du USBR aux États-Unis.
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti‐tubercular agents using a fragment‐based drug design approach (2017)

This article is part of a themed section on Drug Metabolism and Antibiotic Resistance in Micro-organisms. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.14/issuetoc.
Reliability for Networked Storage Nodes (2006)

High-end enterprise storage has traditionally consisted of monolithic systems with customized hardware, multiple redundant components and paths, and no single point of failure. Distributed storage systems realized through networked storage nodes offer several advantages over monolithic systems such as lower cost and increased scalability. In order to achieve reliability goals associated with enterprise-class storage systems, redundancy has to be distributed across the collection of nodes to tolerate both node and drive failures. In this paper, we present alternatives for distributing this redundancy, and models to determine the reliability of such systems. We specify a reliability target and determine the configurations that meet this target. Further, we perform sensitivity analyses where selected parameters are varied to observe their effect on reliability
Renal Injury Associated with Intravenous Pyelography in Nondiabetic and Diabetic Patients (1978)

We studied 23 patients with renal functional deterioration after intravenous pyelography; 16 were nondiabetic. Nondiabetic patients at risk are often elderly and have preexisting renal disease. The course of acute renal failure is fairly characteristic; most patient recover, but some do not. Estimates suggest that the syndrome is not uncommon in susceptible nondiabetic subjects. Pyelography cannot be considered absolutely safe for this group, and alternative diagnostic procedures or caution with contrast dosage and patient preparation may be wise.
Cardiovascular effects of commonly used ophthalmic medications (1996)

Eye disease and cardiovascular disease frequently coexist. As a result, cardiologists and ophthalmologists often treat the same patients. Among ophthalmologists it is well known that topical ophthalmic medications are capable of producing serious cardiovascular effects, including congestive heart failure, arrhythmias, and death. However, cardiologists may not be aware of these potential complications. This article reviews the cardiovascular effects of commonly prescribed topical ocular medications and describes important contraindications to their use in patients with cardiovascular disease. Cardiologists, by making themselves and their patients more aware of the cardiovascular effects of topical ocular medications, may be able to avoid the adverse and potentially fatal complications of these agents.
Complete Genome Sequence of Aeromonas caviae Strain MS6064, a mcr-3 -Carrying Clinical Isolate from Japan (2021)

We report the complete genome sequence of <i>mcr-3</i>-carrying <i>Aeromonas caviae</i> strain MS6064, isolated from a blood sample from a Japanese patient. The strain carried <i>mcr-3</i> variant 3.38 and was borderline resistant to colistin (2 μg/ml).
Specific cases and applications (1995)

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Extrinsic Spin–Orbit Coupling-Induced Large Modulation of Gilbert Damping Coefficient in CoFeB Thin Film on the Graphene Stack with Different Defect Density (2017)

Control of Gilbert damping parameter is imperative for various spintronic and magnonic devices, and various schemes have been attempted to achieve that. We report a large tunability of Gilbert damping by varying the underlayer of CoFeB thin film from few-layer graphene (FLG) to graphite layer. We measured the ultrafast magnetization dynamics of CoFeB, FLG/CoFeB, and graphite/CoFeB by using time-resolved magneto-optical Kerr effect (TR-MOKE) magnetometry. While the magnetization precession frequency remained independent of the underlayer, a very large variation (∼200%) in the value of the Gilbert damping coefficient α is observed from FLG/CoFeB (α ≈ 0.035 ± 0.005) to graphite/CoFeB (α ≈ 0.008 ± 0.001). This large variation of the damping coefficient is understood in terms of the extrinsic spin–orbit interaction of FLG and graphite films, which is very large in FLG due to the presence of large amount of surface defects in it. A faster demagnetization time and fast relaxation time (τ1) were noted for graphite/CoFeB bilayer system than that of FLG/CoFeB. In general, we infer that interfacial spin physics is primarily governed by the growth of CoFeB layer from our bilayer systems. This finding suggests a new direction toward the control of precessional magnetization dynamics, leading to applications in miniaturized high-speed magnetic devices.
Heterologous expression of rat P450 2E1 in a mammalian cell line: in situ metabolism and cytotoxicity of N-nitrosodimethylamine (1998)

GM0637, a human fibroblast cell line, was transfected with pCMV2E1, an expression vector containing the full length cDNA for rat cytochrome P450 2E1 (P450 2E1), and with pCMVneo, which contained vector alone, and the selected clones were designated GM2E1 and GMneo, respectively. Western blot analysis showed that GM2E1, but not GMneo, expressed a protein that reacted with anti-human P450 2E1 antibody. The 7-ethoxycoumarin O-deethylase,p-nitrophenol hydroxylase, and N-nitrosodimethylamine (NDMA) demethylase activities of the P450 in these cells were measured in monolayer cell cultures without preparing microsomes. Exposure of the GM2E1 cells to NDMA for 4 days caused severe decreases in cell viability, as determined by crystal violet uptake, and showed a sigmoidal dose-response curve with a median lethal dose of 17 microM. In contrast, the viability of GMneo cells was not altered by NDMA even at concentrations up to 10 mM. Time- and concentration-dependent methylation of DNA, RNA and protein by [14C]NDMA was only observed in cells expressing P450 2E1. Inhibitors of P450 2E1 activity such as ethanol, 4-methylpyrazole, and isoniazid caused a 90% decrease in the methylation of cellular macromolecules and also completely protected the cells against NDMA-mediated toxicity. The cytotoxicity due to exposure to NDMA was partially inhibited by antioxidants such as N-acetylcysteine, ascorbic acid, butylated hydroxyanisole and N-t-butyl-alpha-phenylnitrone but was not potentiated upon glutathione depletion. These results document the ability of rat P450 2E1 to metabolize NDMA to toxic reactive intermediates and demonstrate that this cell line provides a useful model for studying the mechanisms of metabolism-mediated toxicity and carcinogenesis.
Phase II Study of Adjuvant Immunotherapy with the CSF-470 Vaccine Plus Bacillus Calmette–Guerin Plus Recombinant Human Granulocyte Macrophage-Colony Stimulating Factor vs Medium-Dose Interferon Alpha 2B in Stages IIB, IIC, and III Cutaneous Melanoma Patients: A Single Institution, Randomized Study (2017)

The irradiated, allogeneic, cellular CSF-470 vaccine plus Bacillus Calmette-Guerin (BCG) and recombinant human granulocyte macrophage-colony stimulating factor (rhGM-CSF) is being tested against medium-dose IFN-α2b in stages IIB-III cutaneous melanoma (CM) patients (pts) after surgery in an open, randomized, Phase II/III study. We present the results of the Phase II part of the ongoing CASVAC-0401 study (ClinicalTrials.gov: NCT01729663). Thirty-one pts were randomized to the CSF-470 vaccine (<i>n</i> = 20) or to the IFN-α2b arm (<i>n</i> = 11). During the 2-year treatment, immunized pts should receive 13 vaccinations. On day 1 of each visit, 1.6 × 10<sup>7</sup> irradiated CSF-470 cells plus 10<sup>6</sup> colony-forming units BCG plus 100 µg rhGM-CSF were administered intradermally, followed on days 2-4 by 100 µg rhGM-CSF. IFN-α2b pts should receive 10 million units (MU)/day/5 days a week for 4 weeks; then 5 MU thrice weekly for 23 months. Toxicity and quality of life (QOL) were evaluated at each visit. With a mean and a maximum follow-up of 39.4 and 83 months, respectively, a significant benefit in the distant metastasis-free survival (DMFS) for CSF-470 was observed (<i>p</i> = 0.022). Immune monitoring showed an increase in antitumoral cellular and humoral response in vaccinated pts. CSF-470 was well tolerated; 20/20 pts presented grades 1-2 dermic reactions at the vaccination site; 3/20 pts presented grade 3 allergic reactions. Other adverse events (AEs) were grade 1. Pts in the IFN-α2b arm presented grades 2-3 hematological (7/11), hepatic (2/11), and cardiac (1/11) toxicity; AEs in 9/11 pts forced treatment interruptions. QOL was significantly superior in the vaccine arm (<i>p</i> < 0.0001). Our results suggest that CSF-470 vaccine plus BCG plus GM-CSF can significantly prolong, with lower toxicity, the DMFS of high-risk CM pts with respect to medium-dose IFN-α2b. The continuation of a Phase III part of the CASVAC-0401 study is encouraged.
Low-Energy Focused Ion Beam Doping during Molecular Beam Epitaxial Growth for the Fabrication of Three-Dimensional Devices: The Effect of Dopant Surface Segregation (1995)

An extreme example of surface segregation is found in Sn-doped GaAs grown by molecular beam epitaxy (MBE). Abrupt changes in the doping profile are not possible, instead the dopant concentration decreases exponentially towards the wafer surface from the point at which doping was terminated. In this work it is shown that segregation can be suppressed by implanting the Sn from a very-low-energy (50 to 300 eV) ion beam during growth. The effect of ion implantation energy is studied using secondary ion mass spectroscopy (SIMS) to measure the depth profile of the implanted Sn. It is found that the level of incorporation can be increased by up to a factor of eight using a 300 eV ion energy.
Ground-remote control for space station telerobotics with time delay (1992)

The study proposes a ground-remote telerobot control architecture which could be used for control of Space Station Freedom manipulators. The architecture provides two local-site operator control stations representing potential earth-based and remote Space Station-based operator control stations. A unified control system at the remote site provides autonomous, shared, and teleoperation control for single-and dual-arm task execution. An operational laboratory system which demonstrates the feasibility of various technologies in the proposed architecture, including teleoperation, shared control, and supervised autonomy, is described. Enhancements to the system currently under development, including remote site implementation in Ada, integration and control of a redundant 7-DOF manipulator, and local site advanced operator aids, are also described.
Correction: Modeling the Specific CD4+ T cell Response against a Tumor Neoantigen (2017)

Flament, H., R. A. Ramirez, V. Premel, N. T. Joncker, A. Jacquet, S. Scholl, and O. Lantz. 2015. Modeling the specific CD4+ T cell response against a tumor neoantigen. J. Immunol. 194: [3501–3512][1].

The authors wish to correct an error made in the preparation of Fig. 6. A panel from Fig. 6B
Medicare physician referral patterns. (1999)

Medicare referral patterns are similar to those found in other studies. Patient factors appear to be a more important factor in explaining referrals than was estimated from prior research. Additional research is needed to explain the more complex dynamics of referral patterns.
Purification and Properties of Acid Carboxypeptidase IV from Aspergillus oryzae (1973)

Acid carboxypeptidase IV from Aspergillus oryzae was purified from the rivanol precipitable fraction by column chromatography on DEAE-cellulose, DEAE-Sephadex A–50, hydroxylapatite and P-cellulose and gel filtration through Sephadex G–100. The optimum pH is at pH 3.0 for carbobenzoxy-l-glutamyl-l-tyrosine. The enzyme activity was inhibited by sulfhydryl reagents and diisopropylphosphorofluoridate, but was not inhibited by metal chelating agents. The molecular weight of the enzyme was estimated to be about 43,000 by gel filtration method.
Supplementary Figure Legends 1-4 from Knockdown of Oncogenic KRAS in Non–Small Cell Lung Cancers Suppresses Tumor Growth and Sensitizes Tumor Cells to Targeted Therapy (2023)

Supplementary Figure Legends 1-4 from Knockdown of Oncogenic KRAS in Non–Small Cell Lung Cancers Suppresses Tumor Growth and Sensitizes Tumor Cells to Targeted Therapy
Early AD pathology in a (C-11)PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study Milos D. IkonomovicEric E. AbrahamsonJulie C. PriceRonald L. Hamilton • Chester A. MathisWilliam R. PaljugManik L. DebnathAnne D. Cohen • Katsuyoshi MizukamiSteven T. DeKoskyOscar L. LopezWilliam E. Klunk (2012)

Amyloid-b (Ab) deposits are detectable in the brain in vivo using positron emission tomography (PET) and (C-11)-labeled Pittsburgh Compound B ((C-11)PiB); however, the sensitivity of this technique is not well understood. In this study, we examined Ab pathology in an individual who had clinical diagnoses of probable dementia with Lewy bodies and possible Alzheimer's disease (AD) but with no detectable (C-11)PiB PET retention ((C-11)PiB(-)) when imaged 17 months prior to death. Brain samples were processed in parallel with region- matched samples from an individual with a clinical diag- nosis of probable AD and a positive (C-11)PiB PET scan ((C-11)PiB(?)) when imaged 10 months prior to death. In the (C-11)PiB(-) case, Ab plaques were sparse, occupying less than 2% cortical area, and were weakly labeled with 6-CN-PiB, a highly fluorescent derivative of PiB. In con- trast, Ab plaques occupied up to 12% cortical area in the (C-11)PiB(?) case, and were intensely labeled with 6-CN- PIB. The (C-11)PiB(-) case had low levels of (H-3)PiB binding (\100 pmol/g) and Ab1-42 (\500 pmol/g) con- centration except in the frontal cortex where Ab1-42 values (788 pmol/g) approached cortical values in the (C-11)PiB(?) case (800-1,700 pmol/g). In several cortical regions of the (C-11)PiB(-) case, Ab1-40 levels were within the range of cortical Ab1-40 values in the (C-11)PiB(?) case. Antemortem (C-11)PiB DVR values correlated well with region-matched postmortem measures of Ab1-42 and Ab1-40 in the (C-11)PiB(?), and with Ab1-42 only in the (C-11)PiB(-) case. The low ratios of (H-3)PiB binding levels to Ab concentrations and 6-CN- PiB to Ab plaque loads in the (C-11)PiB(-) case indicate that Ab pathology in the brain may be associated with low or undetectable levels of (C-11)PiB retention. Studies in greater numbers of (C-11)PiB PET autopsy cases are
Function and Accuracy of Glucose Sensors Beyond Their Stated Expiry Date (2006)

Neither the expiry date nor the 3-day period of use limits the reliable function of a CGMS sensor. Sensors were found to function as long as 18 months after the expiry date, mostly for at least 7 days. There were no serious local adverse reactions. Prolongation of shelflife label and insertion time appears to be reasonable. Further studies are in progress.
Visualization of podocyte substructure with structured illumination microscopy (SIM): a new approach to nephrotic disease (2016)

A detailed microscopic analysis of renal podocyte substructure is essential to understand and diagnose nephrotic kidney disease. Currently only time consuming electron microscopy (EM) can resolve this substructure. We used structured illumination microscopy (SIM) to examine frozen sections of renal biopsies stained with an immunofluorescence marker for podocin, a protein localized to the perimeter of the podocyte foot processes and compared them with EM in both normal and nephrotic disease biopsies. SIM images of normal glomeruli revealed curvilinear patterns of podocin densely covering capillary walls similar to podocyte foot processes seen by EM. Podocin staining of all nephrotic disease biopsies were significantly different than normal, corresponding to and better visualizing effaced foot processes seen by EM. The findings support the first potential use of SIM in the diagnosis of nephrotic disease.
Myeloproliferative neoplasms in the young: Mayo Clinic experience with 361 patients age 40 years or younger (2018)

Between 1967 and 2017, 361 patients with myeloproliferative neoplasms (MPN), age ≤ 40 years, were seen at our institution, constituting 12% of all MPN patients (n = 3023) seen during the same time period; disease-specific incidences were 12% in polycythemia vera (PV; n = 79), 20% in essential thrombocythemia (ET; n = 219) and 5% in primary myelofibrosis (PMF; n = 63). Compared to their older counterparts, younger patients were more likely to present with low risk disease (P < .001) and display female preponderance in ET (P = .04), lower incidence of arterial events overall (P < .001), and higher incidence of venous thrombosis in PV (P = .01). Younger patients were also more likely to express CALR mutations, in ET and PMF, normal karyotype, in PV and PMF, and lower incidence of high molecular risk mutations in PMF (P significant in all instances). Over median follow-up of 11.3, 13, and 7.1 years for PV, ET, and PMF, leukemic transformations were respectively documented in 4%, 2%, and 10% (P values 0.1-0.9) while incidences of fibrotic progression in PV (22%) and ET (16%) were expectedly higher in young patients, because of their longer survival (P < .001). Median survival in young patients was 37 years for PV, 35 for ET and 20 for PMF; the corresponding values were 22, 22, and 8 years for ages 41-60 years and 10, 11, and 3 years for ages >60 years (P < .001). Young MPN patients comprise a unique disease subset defined by an attenuated-risk cytogenetic and mutational backdrop and conspicuously longer survival compared to their older counterparts, which requires assertion during patient counseling.
REVIEWS (1960)

REVIEWS I. EPSTEIN, Judaism. A Historical Presentation. (Pelican Books, A440.) 1959. Pp. 350. ( Penguin Books, Harmondsworth. Price: 3s. 6d.) MARCEL SIMON MARCEL SIMON Search for other works by this author on: Oxford Academic Google Scholar Journal of Semitic Studies, Volume 5, Issue 4, October 1960, Pages 439–440, https://doi.org/10.1093/jss/5.4.439 Published: 01 October 1960
Coverage in interpolation-based model checking (2010)

Coverage is a means to quantify the quality of a system specification, and is frequently applied to assess progress in system validation. Coverage is a standard measure in testing, but is very difficult to compute in the context of formal verification. We present efficient algorithms for identifying those parts of the system that are covered by a given property. Our algorithm is integrated into state-of-the-art SAT-based Model Checking using Craig interpolation. The key insight of our algorithm is to re-use previously computed inductive invariants and counterexamples. This re-use permits a quick conclusion of the vast majority of tests, and enables the computation of a coverage measure with 96% accuracy with only 5x the runtime of the Model Checker.
Common Angiogenic Signaling Pathways Induced by Monomeric C - reactive protein and FGF-2 through MAPK and PI3K (2017)

Excessive angiogenesis (i.e. neovascularization) in atherosclerotic lesions, sites of dissociation of the inflammatory biomarker pentameric C-reactive protein (pCRP) into monomeric CRP (mCRP), represents a focus of plaque instability with haemorrhagic complications. We previously demonstrated mCRP pro-angiogenic effects on cultured aortic endothelial cells. However, mCRP effects in combination with FGF-2, pro-angiogenic factor released by activated macrophages infiltrating developing lesions, have not yet been described. Here, we examined in vitro the angiogenic capabilities of mCRP combined with FGF-2 by performing endothelial cell proliferation, migration, and differentiation including tube formation and spheroid sprouting assays. The signaling pathways were also investigated by Western blotting and all the cell-based assays were used with or without pharmacological inhibitors of mitogen-activated protein kinase (MAPK), phosphatidylinositol-3 kinase (PI3K) and ÃƒÅ½Ã‚Â³-secretase, considered as key regulators of angiogenesis. We showed that mCRP-induced endothelial cell proliferation and migration required activation of PI3K pathway. MAPK pathway was essential in mCRP-induced endothelial cell proliferation and spheroid sprouting while ÃƒÅ½Ã‚Â³-secretase activity was indispensable for mCRP-induced tube formation only. MAPK pathway was required in all FGF-2-stimulated angiogenic assays whereas ÃƒÅ½Ã‚Â³-secretase slightly inhibited FGF-2 angiogenic effects. PI3K pathway was necessary for FGF-2 angiogenic activities except for cell differentiation. In most of the assays, the additive pro-angiogenic effects of mCRP combined to FGF-2 were mainly attenuated by PI3K and MAPK inhibitors. Altogether, mCRP and FGF-2 have common angiogenic signaling pathways through PI3K and MAPK. Thus, the therapeutic use of PI3K and MAPK inhibitors may inhibit this increased vascularization whilst reducing the haemorrhagic complications from unstable plaques.
Towards larger and thinner wafers used in photovoltaic (2005)

The main targets of the photovoltaic industry today is the development of wafer geometry to save manufacturing costs. These motivate the investigation of ways to increase wafer size and reduce wafer thickness systematically. Another motivation is the shortage of solar grade silicon as a feedstock for crystalline silicon technology. Recent technologies have shown the possibility of slicing larger and thinner wafers due to the accelerated and continuous development wire sawing and cutting/slicing technology. Wafers as large as 200 mm /spl times/ 200 mm and as thin as 150 /spl mu/m can be produced.