gebhart/patrepeval huggingface dataset:
Abstract 538: LC-MS based catabolite identification study of an ADC with DM21-C, a novel maytansinoid linker-payload (2019)

Abstract ImmunoGen’s newest antibody-drug conjugate (ADC) design uses the novel maytansinoid linker-payload, DM21-C that bears a peptidase/protease cleavable linker. These ADCs show good bystander killing of proximal antigen negative cells, suggesting the generation of cell-permeable catabolites. The goal of this study was to identify the catabolites generated upon incubation in antigen-positive cancer cells (both cell pellet and media), in mouse plasma, as well as in in vitro catabolic systems. Upon incubation with a cysteine-conjugated DM21-C ADC, the small molecule fraction was extracted with an organic solvent and analyzed by high resolution mass spectrometry after chromatographic separation. Through comparison to reference standards, mass spectral signal extraction of possible products, and database search of unknown peaks, the potential in vitro catabolite products of DM21-C conjugate were identified. Information on linker-payload stability in these model systems, including plasma stability, in vitro metabolism of the ADC, and catabolic products that were both retained and effluxed from cancer cells was obtained. As a result, we identified DM51 (the thiol- resulting from self-immolation of the cleaved linker-payload) as a major catabolite of the DM21-C ADC. Citation Format: Janet Lau, Paulin Salomon, Kerstin Sinkevicius, Juliet Costoplus, Megan Fuller, Raymond Xu, Stuart Hicks, Ravi Chari, Wayne Widdison, Nicholas Yoder, Thomas Keating. LC-MS based catabolite identification study of an ADC with DM21-C, a novel maytansinoid linker-payload [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 538.
Persistence Length of Human Cardiac α-Tropomyosin Measured by Single Molecule Direct Probe Microscopy (2012)

α-Tropomyosin (αTm) is the predominant tropomyosin isoform in adult human heart and constitutes a major component in Ca²+-regulated systolic contraction of cardiac muscle. We present here the first direct probe images of WT human cardiac αTm by atomic force microscopy, and quantify its mechanical flexibility with three independent analysis methods. Single molecules of bacterially-expressed human cardiac αTm were imaged on poly-lysine coated mica and their contours were analyzed. Analysis of tangent-angle (θ(s)) correlation along molecular contours, second moment of tangent angles (<θ²(s)>), and end-to-end length (L(e-e)) distributions respectively yielded values of persistence length (L(p)) of 41-46 nm, 40-45 nm, and 42-52 nm, corresponding to 1-1.3 molecular contour lengths (L(c)). We also demonstrate that a sufficiently large population, with at least 100 molecules, is required for a reliable L(p) measurement of αTm in single molecule studies. Our estimate that L(p) for αTm is only slightly longer than L(c) is consistent with a previous study showing there is little spread of cooperative activation into near-neighbor regulatory units of cardiac thin filaments. The L(p) determined here for human cardiac αTm perhaps represents an evolutionarily tuned optimum between Ca²+ sensitivity and cooperativity in cardiac thin filaments and likely constitutes an essential parameter for normal function in the human heart.
Recent developments in the coordination chemistry of bis(imino)acenaphthene (BIAN) ligands with s- and p-block elements (2008)

Bis(imino)acenaphthenes (BIAN) have been known for many years. However, it is only since the 1990s that such compounds have been recognized as robust ligands for the support of catalytically active transition metal centers. More recently, the unique stereoelectronic properties of the BIAN ligand class are beginning to be appreciated and exploited for some fascinating new developments in synthetic, structural and catalytic s- and p-block chemistry.
Superthreading: Integrating Compilation Technology and Processor Architecture for Cost-Effective Concurrent Multithreading (1998)

As the number of transistors that can be integrated on a single chip continues to grow, it is important\nfor computer architects to think beyond the traditional approaches of deeper pipelines and wider\ninstruction issue units for improving performance. This single-threaded execution model limits these\napproaches to exploiting only the relatively small amount of instruction-level parallelism available\nin application programs. While integrating an entire multiprocessor onto a single chip is feasible,\nthis architecture is limited to exploiting only relatively coarse-grained heavy-weight parallelism.\nWe propose the superthreaded architecture as an excellent alternative for utilizing the large number\nof transistors that will become available on a single high-density chip. As a hybrid of a wideissue\nsuperscalar processor and a multiprocessor-on-a-chip, this new concurrent multithreading\narchitecture can leverage the best of existing and future parallel hardware and software technologies.\nBy incorporating speculation for control dependences and run-time checking of data dependences,\nthe superthreaded architecture can exploit the multiple granularities of parallelism available in\ngeneral-purpose application programs to reduce the execution time of a single program.
Antiirritant Properties of Polyols and Amino Acids (2011)

Similar to the action of the well-known antiirritant glycerol, SLS-induced skin irritation is suppressed by xylitol and taurine. These results suggest that these agents might also be effective in preventing irritative dermatitis.
The Commercial Pilot of the Future (1995)

The role of the commercial pilot has undergone significant changes in recent times. Technological advances and shifting commercial emphasis has resulted in requirements of the pilot that are not addressed by current training structures. In response to this, training and education of career pilots at tertiary level is a growing trend worldwide and a trend that is supported by the demands of the industry within Australia. The University of New South Wales is one of a small group to respond to these demands by initiating a career specific degree, The Bachelor of Aviation. This is a degree which combines basis skills with the higher order competencies that are the essence of tertiary study. It does this by integrating a core of academic study with pilot training so as to produce a pilot who is capable of meeting the needs of the industry now and into the future.
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19 (2021)

Herein is described the development of a large-scale manufacturing process for molnupiravir, an orally dosed antiviral that was recently demonstrated to be efficacious for the treatment of patients with COVID-19. The yield, robustness, and efficiency of each of the five steps were improved, ultimately culminating in a 1.6-fold improvement in overall yield and a dramatic increase in the overall throughput compared to the baseline process.
Detection of chlorinated methanes by tin oxide gas sensors (2001)

Tin oxide thin films prepared by thermal oxidation of Sn films were used for the detection of chlorinated methanes (CH2Cl2, CHCl3 and CCl4). This resulted in better chemical selectivity, sensitivity, response speed and detection limit than seen with previous detectors. The temperature dependence of the sensing of 1% CCl4 gas was studied and the best sensing behavior was observed at 300 degrees C. The films showed different chemical selectivity in both speed and direction of sensing response to each gas and were stable for more than 3 weeks under operating conditions. The films showed rapid gas sensing (<40 s to reach 90% of full response) and low detection limits (< 4 ppm CCl4). The role of oxygen in the detection of chlorinated methanes and in resistance changes without chlorinated methanes was also studied. The changes at the surface of the film after gas sensing were examined using scanning electron microscopy with energy-dispersive X-ray spectrometry.
Molecular characterization of PcpA: a novel choline-binding protein ofStreptococcus pneumoniae (1998)

The gene pcpA that encodes a novel pneumococcal choline-binding protein has been cloned and characterized. Northern blot analysis revealed that pcpA is expressed during the exponential phase of growth of pneumococci as a monocistronic transcript of about 2.3 kb. The transcription start site has been located 132 bp upstream of the start codon and the proposed -35 and -10 boxes that are highly similar to those of the typical sigma 70 promoters from Escherichia coli. This gene encodes a putative 79 kDa protein that contains a typical C-terminal choline-binding domain (ChBD). The ChBD of PcpA is built up by 11 identical motifs of 20 amino acids plus a tail of 19 amino acids, which represents the longest ChBD that has been characterized so far. Interestingly, two tandem arrays of five characteristic amphipathic leucine reach repeats (LRRs) of 22-26 amino acids in length have been found in the N-terminal region of PcpA. Since LRRs have been proposed to be involved in protein-protein and protein-lipid interactions our findings suggests a role for PcpA in pneumococcal adhesion.
Notes on Transient THD Effects in a Lubricating Film (1992)

An analysis of the transient thermohydrodynamic behavior of the lubricating film in a journal bearing is presented. The energy equation and the Reynolds equation are uncoupled and a simplified form of the energy equation is derived by integrating an assumed form of temperature distribution across the film thickness. This equation gives the mean film temperature subjected to an adiabatic boundary condition at the oil-bush interface and a boundary condition that imposes a uniform circumferential temperature at the oil-shaft interface. An algorithm is developed which efficiently solves the equation for the transient, mean film temperature. Numerical results are presented for several operating parameters.
COMPOSITION, QUALITE DE L'EAU DE GACHAGE, RAPPORT EAU/CIMENT, HOMOGENEITE (1987)

L'AUTEUR PRESENTE EN DETAIL UNE METHODE DE COMPOSITION DU BETON - LA METHODE DOE - POUR LA FORMULATION DE MELANGES DE MASSE NORMALE. IL EST MONTRE QUE LES DIFFERENTES VARIABLES UTILISEES DANS CETTE METHODE (RESISTANCE A LA COMPRESSION, QUANTITE D'EAU REQUISE, PROPORTION DE FINES) PEUVENT ETRE DEFINIES PAR DES EQUATIONS RELATIVEMENT SIMPLES. ON ETUDIE TROIS SORTES DE BETONS : BETONS PORTLAND, BETONS AUX CENDRES VOLANTES, BETONS A AIR OCCLUS. UNE ATTENTION PARTICULIERE EST CONSACREE A L'INFLUENCE DU RAPPORT EAU/CIMENT SUR LA RESISTANCE A LA COMPRESSION, LA VARIABILITE DE LA RESISTANCE, LA QUANTITE D'EAU REQUISE ET LA QUALITE DE L'EAU DE GACHAGE. (A). (VOIR FICHE GENERALE DIRR 121487).
A report on the “new frontiers in group 13 chemistry” symposium from the 88th Canadian Society for Chemistry Conference and Exhibition (2007)

Abstract The 88th Canadian Society for Chemistry Conference and Exhibition was held in Saskatoon, Saskatchewan, during the period of May 28–June 1, 2005. More than 250 chemists from various academic institutes and industries enjoyed five plenary lectures, thirteen oral presentations and a plethora of poster presentations. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:323–332, 2007; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20287
Low voltage, high repetition rate electro-optic Q-switch (2005)

A low voltage, high repetition rate electro-optic Q-switch using OptoCeramic/spl reg/ PMN-PT was developed. A solid-state laser with repetition rate as high as 200 KHz with switching voltage as low as 48 volts has been demonstrated.
A Foundation for the Design and Analysis of Robotic Systems and Behaviors (1994)

Robots are generally composed of electromechanical parts with multiple sensors and actuators. The overall behavior of a robot emerges from coordination among its various parts and interaction with its environment. Developing intelligent, reliable, robust and safe robots, or real-time embedded systems, has become a focus of interest in recent years. In this thesis, we establish a foundation for modeling, specifying and verifying discrete/continuous hybrid systems and take an integrated approach to the design and analysis of robotic systems and behaviors. A robotic system in general is a hybrid dynamic system, consisting of continuous, discrete and event-driven components. We develop a semantic model for dynamic systems, that we call Constraint Nets (CN). CN introduces an abstraction and a unitary framework to model discrete/continuous hybrid systems. CN provides aggregation operators to model a complex system hierarchically. CN supports multiple levels of abstraction, based on abstract algebra and topology, to model and analyze a system at different levels of detail. CN, because of its rigorous foundation, can be used to define programming semantics of real-time languages for control systems. While modeling focuses on the underlying structure of a system --- the organization and coordination of its components --- requirements specification imposes global constraints on a system''s behavior, and behavior verification ensures the correctness of the behavior with respect to its requirements specification. We develop a timed linear temporal logic and timed $\forall$-automata to specify timed as well as sequential behaviors. We develop a formal verification method for timed $\forall$-automata specification, by combining a generalized model checking technique for automata with a generalized stability analysis method for dynamic systems. A good design methodology can simplify the verification of a robotic system. We develop a systematic approach to control synthesis from requirements specification, by exploring a relation between constraint satisfaction and dynamic systems using constraint methods. With this approach, control synthesis and behavior verification are coupled through requirements specification. To model, synthesize, simulate, and understand various robotic systems we have studied in this research, we develop a visual programming and simulation environment that we call ALERT: A Laboratory for Embedded Real-Time systems.
Vehicle lane detection and following based on vision system and laser scanner (2017)

The road lane detection technique is developed based on an on-board PC-based vision system. Different image processing techniques were adopted to find out the lane relative location on camera image, This lane information is integrated with vehicle frontal view laser scanning information to plan the vehicle moving path based on cubic-spline trajectory planning and generate the vehicle steering angle command on-line as an advanced driving assistance system. These lane and obstacle detection system are installed on a four wheel motors electric model vehicle with embedded FPGA control structure for experimental tests on campus sport field.
Driver Support System bv the Prediction of Driving Maneuver (2004)

This paper proposed an approach to design a driver support system. The driver support system which prevents unsafe confirmation is useful for reducing the traffic accidents during the intersection. The support system consists of the following three parts. The role of first part is to judge if the driver's confirmation is unsafely. The judgment is based on driver's gaze angles which are measured by CCD camera. The second part is to predict the driving maneuver in order to support in the early stage. The driving maneuver is predicted by Bayesian network (BN) which the parameters are learned every individual driver. Hence the prediction is adapted to each driver. The third part is to judge whether the support is necessary based on the output of previous two parts. Because of considering both confirmation behavior and driving maneuver, it is possible to judge more correctly. The parameters to design the system is tuned by and learned from data of driving simulator (DS) experiments, where the subjects drive repeatedly on the same road including some intersections with stop signs. Using these data, the system which is based on usual driving behavior is constructed. Finally, the effect of the supporting system is shown by the results of DS experiments.
Exostosenbildung des inneren Gehörganges bei einem Patienten mit myotoner Dystrophie Curschmann-Steinert (2006)

A 53-year-old patient with myotonic dystrophy presented to our clinic with progressive bilateral hearing loss. The ENT status and particularly the otological examination were without pathological signs. Pure tone audiograms showed a bilateral moderate to severe sensorineural hearing loss. Routinely performed computed tomography of the temporal bones revealed the rare picture of exostosis of the internal auditory canals and the medial surface of the petrous bones. To our knowledge, this is the first report describing exostosis of the internal auditory canal in a patient with myotonic dystrophy, although at present it remains unclear in how far there is a causal connection between these two pathologies.
O GEIA e a aplicação da agroecologia na mediação entre a escola, a universidade e sociedade francana (2015)

This article’s purpose is to present the extension group GEIA -“Grupo de Incentivo a Educação Ambiental”, originated in Universidade Estadual Paulista, Campus of Franca - SP. This group has a pioneer and innovative project because, among all the UNESP campus, it is the only one to engage in the formation of an agroforest inside the university, through techniques that are not well spread in the country. along with and complementary to the agroforest, the group has another project, the environmental education project for children in a public elementary school, having it’s educational methods guided by the principles of horizontal and popular education. Thus, GEIA proves itself to be necessary inside the public university environment, once it has the fundamental social role of forming critical and conscious agents, aware of their transforming capacity, besides having the responsibility of bringing to the external society the academic and practical knowledge.
High efficiency integral III-N/II-VI blue-green laser converter (2007)

An integral optically-pumped laser converter comprising an ultra-low-threshold green (∼540 nm) CdSe quantum dot laser chip pumped by a blue InGaN/GaN quantum well heterostructure laser grown on Si (111) substrates has been fabricated and studied. The maximum achieved quantum efficiency and pulse output power in green are as high as 14% and 3 W, respectively.
Superimposed asymmetric modulation in narrowband fading channels using orthogonal codes (2006)

The asymmetric signal constellation (ASC) method to break isometry is analyzed in a superimposed symbol framework with a Kalman filter estimator (KF) / maximum-likelihood (ML) detector as the receiver. Direct application of the ASC method led to a bit error floor, which motivates the proposal of combining orthogonal spreading codes with ASC to solve this problem. The proposed scheme generalizes previously proposed ASC and pilot-assisted solutions in a systematic way and results in coherent detection schemes without set bit error floors and better performance
LAMININ AND FIBRONECTIN MODULATE THE PRESENCE AND DISTRIBUTION OF THE αv INTEGRIN SUBUNIT IN SKELETAL MYOFIBERS AND MYOTUBES. (1995)

*Dept. Physical Therapy and Dept. of Physiology, School of Medicine, University of Maryland at Baltimore, MD 21201.
Efficient synthesis of metal binding peptides incorporating aminodiacetic acid based ligands (1995)

New N alpha-Fmoc/Bu(t) protected amino acids bearing half-EDTA side chains (CH2)nN(Ada-O-Bu(t))2 n = 1 (5), n = 2 (24), n = 3 (10), n = 4 (15) were prepared in satisfactory yields. These derivatives can be conveniently used in a solid-phase peptide synthesis as they are devoid of serious shortcomings of Boc/Bzl based syntheses of metallopeptides, such as preliminary peptide capping as well as undesired lactamization of 5 during the peptide synthesis. Munksgaard 1995.
Novel Tm:(Y,Sc)2O3 Transparent Ceramics for Laser Applications (2021)

Thulium doped mixed sesquioxides are well suited for the generation of ultra-short laser pulses in the 2-μm spectral range and for the extension of the laser tuning interval due to formation of solid solutions exhibiting a non-uniform distribution of the crystal field in the dopant occupation sites [1] , [2] . This effect inhomogeneously broadens the absorption and the emission spectra of the lasing ions with respect to the "pure" compositions.
Characterization of the voltage and electric field stresses in multi-cell solid-state transformers (2014)

Solid-State Transformers (SSTs) are a promising technology since they enable a reduction in weight and volume of transformers while integrating new functionalities and services in the grid. However, a new kind of electric stress for the insulation occurs in this type of power converter, given that low-frequency medium-voltage stresses are mixed with high-frequency stresses generated by the converter's switching actions. This paper analyzes, in time and frequency domains, the voltage stresses appearing in cascaded converters, employing converter cells based on two-level or three-level bridge legs. The highest electric fields occur in the medium-frequency transformers of the converter cells' DC-DC converters, which provide galvanic isolation within the SST. Numerical simulations of the electric field distributions in these transformers are presented for the different frequency components and the impact of the converter topology on the insulation stress is highlighted. Furthermore, it is shown that the dielectric losses of the transformer can be neglected despite the presence of high-frequency harmonics. Finally, a transformer insulation concept based on semiconducting tape is proposed.
Design and implementation of teaching analysis system based on data mining (2019)

With the development of informatization and data collection, more and more educational process data can be obtained by education practitioners, and these massive data need to be processed in order to be used by people. Based on the classical algorithm and technical principle of data mining, this paper designs and implements a teaching analysis system based on data mining, which mainly provides the related functions of clustering analysis, regression analysis and association analysis for users. According to the K-means algorithm, the students' data are divided into several clusters in order to complete the clustering analysis of the students' scores. FP-Growth algorithm is used to analyze the strong association rules between courses. Through Python's drawing package, the data can be displayed clearly and intuitively, thus completing the data visualization. Finally, a user-friendly interface is built by PyQt5, and the analysis results are visualized and output.
Supplementary Materials and Methods from Neuroendocrine Transdifferentiation in Human Prostate Cancer Cells: An Integrated Approach (2023)

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