gebhart/patrepeval huggingface dataset:
Account of Nitroarene Reduction with Size- and Facet-Controlled CuO–MnO2 Nanocomposites (2014)

In this work, we propose a systematic and delicate size- and shape-controlled synthesis of CuO-MnO2 composite nanostructures from time-dependent redox transformation reactions between Cu2O and KMnO4. The parental size and shape of Cu2O nanostructures are retained, even after the redox transformation, but the morphology becomes porous in nature. After prolonged reaction times (>24 h), the product shapes are ruptured, and as a result, tiny spherical porous nanocomposites of ∼100 nm in size are obtained. This method is highly advantageous due to its low cost, its easy operation, and a surfactant or stabilizing agent-free approach with high reproducibility, and it provides a facile but new way to fabricate porous CuO-MnO2 nanocomposites of varied shape and size. The composite nanomaterials act as efficient recyclable catalysts for nitroarene reduction in water at room temperature. The time-dependent reduction kinetics can be easily monitored by using UV-vis spectrophotometer. The catalytic system is found to be very useful toward the reduction of nitro compounds, regardless of the type and position of the substituent(s). Furthermore, it is revealed that CuO-MnO2 composite nanomaterials exhibit facet-dependent catalytic activity toward nitroarene reduction, where the (111) facet of the composite stands to be more active than that of the (100) facet. The results are also corroborated from the BET surface area measurements. It is worthwhile to mention that porous tiny spheres (product of 48 h reaction) exhibit the highest catalytic activity due to pronounced surface area and smaller size.
Broadening participationOpening remarks (2009)

Highlighting efforts and providing the rationale to increase the participation and success of underrepresented groups in computing.
Electrochemistry of some ethyl α-bromo(dihalophenyl) acetates and electrochemical synthesis of diastereoisomeric diethyl 2,3-bis (dihalogenophenyl) succinates (1990)

Ethyl α-bromo-2,4- or -3,4-dihalogenophenylacetates (ABr), where halogen = F or Cl, are prepared and electrolysed on reticulated vitreous carbon (RVC) in dimethylformamide containing Et4NClO4(0.1 mol dm–3). Potentiostatic reduction at E=–1.6 to –1.8 V versus SCE furnishes the corresponding racemic and meso succinates (AA)(13)–(16). Monoesters AH (5)–(8) are also isolated. An excess pf racemic isomer is observed for (14), (15), and (16). Voltammetric experiments show practically no difference between the reduction potentials of the isomeric compounds. Diastereoisomers can be distinguished by NMR spectroscopy, allowing diastereoisomeric excess (de) to be evaluated before isolation of the single products. A mechanism involving radical intermediates A˙ cannot be excluded. On this basis, the des can be explained by assuming different geometries for A˙ when the phenyl group bears different substituents.
Kinetics of cyclocreatine and Na+ cotransport in human breast cancer cells: mechanism of activity (1999)

The growth-inhibitory effect of cyclocreatine (CCr) and the kinetics of CCr and Na(+) cotransport were investigated in MCF7 human breast cancer cells and its adriamycin-resistant subline with use of (31)P- and (23)Na-NMR spectroscopy. The growth-inhibitory effect in the resistant line occurred at a lower CCr concentration and was more pronounced than in the wild-type line. This correlated with an approximately 10-fold higher affinity of CCr to the transporter in the resistant line. The passive diffusion coefficient of CCr was also higher in the resistant line by three- to fourfold. The transport of CCr was accompanied by a rapid increase in intracellular Na(+). This increase was found to depend on the rate of CCr transport and varied differently with CCr concentration in the two cell lines. It is proposed that the cotransport of CCr and Na(+) followed by increased Na(+) concentration, together with the accumulation of the highly charged phosphocyclocreatine, are responsible for cell swelling and death.
Towards a Healthy Car: UVC LEDs Inside Automobile HVAC Chamber Offers Effective Complementary Disinfection to Ensure Clean Cabin Air (2022)

Vehicle HVAC systems can accumulate and recirculate highly infectious respiratory diseases via aerosols. Integrating UVC to complement automobile HVAC systems can protect occupants from developing allergies, experiencing inflammatory problems, or acquiring respiratory infectious diseases by inactivating pathogenic organisms. UVC can add little to no static pressure with minimal space, unlike mercury lamps which are larger and heavier. Additionally, UVC LEDs are effective at low voltage and have no mercury or glass. While previous experiments have shown UVC LED technology can reduce bacteriophage Phi6 concentrations by 1 log in 5 minutes (selected as the average time to clean the cabin air), those studies had not positioned LED within the HVAC itself or studied the susceptibility of the surrogate at the specific wavelength. This study aimed to assess the disinfection performance of UVC LEDs in automotive HVAC systems and determine the dose-response curve for bacteriophage Phi6, a SARS-CoV-2 surrogate. To achieve this, UVC LEDs were installed in a car HVAC system. To determine inactivation efficacy, a model chamber of 3.5 m3, replicating the typical volume of a car, containing the modified automobile HVAC system was filled with bacteriophage Phi6, and the HVAC was turned on with and without the UVC LEDs being turned on. The results revealed that HVAC complemented with UVC reduced bacteriophage Phi6 levels significantly more than the HVAC alone and reduced the viral concentration in the cabin by more than 1 LRV (90% viral reduction) in less than 5 minutes. The performance after 5 minutes is expected to be significantly better against SARS-CoV-2 because of its higher sensitivity to UVC, especially at lower wavelengths (below 270 nm). HVAC alone could not achieve a 90% viral reduction of bacteriophage Phi6 in 15 minutes. Applying UVC LEDs inside an HVAC system is an effective means of quickly reducing the number of aerosolized viral particles in the chamber, by inactivating microorganisms leading to improved cabin air quality.
Data from Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; We set out to identify Stearoyl-CoA desaturase 1 (SCD1) as a novel molecular target in clear cell renal cell carcinoma (ccRCC) and examine its role in tumor cell growth and viability &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; independently as well as in combination with current U.S. Food and Drug Administration (FDA)-approved regimens.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Patient normal and ccRCC tissue samples and cell lines were examined for &lt;i&gt;SCD1&lt;/i&gt; expression. Genetic knockdown models and targeted inhibition of SCD1 through use of a small molecule inhibitor, A939572, were analyzed for growth, apoptosis, and alterations in gene expression using gene array analysis. Therapeutic models of synergy were evaluated utilizing pharmacologic inhibition of SCD1 with the tyrosine kinase inhibitors (TKI) sunitinib and pazopanib, and the mTOR inhibitor temsirolimus.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Our studies identify increased &lt;i&gt;SCD1&lt;/i&gt; expression in all stages of ccRCC. Both genetic knockdown and pharmacologic inhibition of SCD1 decreased tumor cell proliferation and induced apoptosis &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;. Upon gene array, quantitative real-time PCR, and protein analysis of A939572-treated or SCD1 lentiviral knockdown samples, induction of endoplasmic reticulum stress response signaling was observed, providing mechanistic insight for SCD1 activity in ccRCC. Furthermore, combinatorial application of A939572 with temsirolimus synergistically inhibited tumor growth &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Increased SCD1 expression supports ccRCC viability and therefore we propose it as a novel molecular target for therapy either independently or in combination with an mTOR inhibitor for patients whose disease cannot be remedied with surgical intervention, such as in cases of advanced or metastatic disease. &lt;i&gt;Clin Cancer Res; 19(9); 2368–80. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Alcohol Losses from Entrainment in Carbon Dioxide Evolved during Fermentation (1964)

Total losses of alcohol entrained in CO<sub>2</sub> in laboratory experiments were shown to increase with: temperature of fermentation, alcohol level of wine fermented, agitation of fermenting liquid, and presence of a pomace cap. As expected, the rate of loss of alcohol entrained in CO<sub>2</sub> per unit of time reaches a maximum about the middle of fermentation, i.e. during maximum activity. For four cellar fermentations, alcohol losses entrained in CO<sub>2</sub> are reported as % of alcohol production at four instants during fermentation. The rate of loss of alcohol expressed in this way rises to a maximum toward the end of fermentation. No differences in losses of alcohol in CO<sub>2</sub> were observed between the open and closed fermenters. Total losses of alcohol by evaporation and entrainment in CO<sub>2</sub> for laboratory fermentations af 26.5°C (79.7°F) were 0.65% for juice with 21° initial Balling, 0.84% for must with 21° initial Balling, and 0.16% for distilling material with 5.5° initial Balling. For plant fermentations at 25.5°C (77.9°F), the loss was 0.7% for must with 16° initial Balling. These losses are in good agreement with previous findings.
Paclitaxel plus carboplatin in the treatment of ovarian cancer. (1999)

Two large, prospective randomized trials by the Gynecologic Oncology Group and the European Organization for Research and Treatment of Cancer have demonstrated the superiority of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ)/cisplatin compared with cisplatin/cyclophosphamide in previously untreated patients with advanced ovarian cancer. Patients receiving the paclitaxel combination had a higher overall response rate, a longer time to disease progression, and prolonged median survival. In an effort to reduce toxicity, investigators developed combinations of carboplatin/paclitaxel that were found by phase I/II trials to have activity comparable to cisplatin/paclitaxel but with less toxicity. Prospective randomized trials of paclitaxel/cisplatin versus paclitaxel/carboplatin were completed by the Gynecologic Oncology Group and by European investigators and preliminary results identify no differences in efficacy. Clinical trials of new combinations of paclitaxel/carboplatin with oral etoposide, gemcitabine, or epirubicin have recently begun. Additional studies of high-dose chemotherapy regimens of paclitaxel/carboplatin in untreated patients with optimal stage III ovarian cancer also are in progress. The Gynecologic Oncology Group has completed a randomized comparison of three versus six cycles of paclitaxel/carboplatin in early stage disease. This study will be followed by a trial in which all patients with poor-prognosis, early stage ovarian cancer receive three cycles of paclitaxel/carboplatin followed by randomization to no further treatment or to weekly paclitaxel. The combination of paclitaxel/carboplatin is currently the preferred regimen for the treatment of ovarian cancer.
Transient hypothyroidism reinitiates egg laying in turkey breeder hens: termination of photorefractoriness by propylthiouracil (1997)

A study was conducted to determine the effects of transient hypothyroidism induced by propylthiouracil (PTU) on termination of photorefractoriness and reinitiation of lay in turkey breeder hens. The PTU was given for 6- or 8-wk periods via the feed and at various doses to yearling hens that had been continuously exposed to long photoperiods [16 h light (L):8 h dark (D)] for at least 25 wk. There was a dose-dependent cessation of lay as well as deletion of thyroxine (T4) and triiodothyronine (T3) during the treatment period. Hens receiving 0.1% PTU or more had little or no circulating thyroid hormones after 2 wk of treatment. Furthermore, resumption of a normal rate and duration of egg laying occurred following withdrawal of the PTU, without any changes in photoperiod. However, this effect only occurred in those hens that had received PTU doses of 0.1% or more and only when the treatment had been given for greater than 6 wk. The resumption of normal levels of egg laying occurred in the absence of a typical preceding molt. Body weights, livability, and fertility and hatchability of eggs from these hens were similar to those of controls. Clearly, turkey hens can be effectively recycled by pharmacological manipulation of the thyroid gland and the results are supportive of thyroid hormone(s) involvement in maintaining photorefractoriness in turkey hens.
USL255 extended-release topiramate for the treatment of epilepsy (2014)

USL255 is a once-daily, extended-release formulation of the well-established antiepileptic drug topiramate that was recently approved by the US FDA. As a capsule formulation, USL255 can be swallowed intact or opened and sprinkled onto soft food for patients with swallowing difficulties, including children (≥2 years old) and older patients. USL255 has been evaluated in seven key Phase I and III studies. Compared with immediate-release topiramate taken twice daily, once-daily USL255 provides equivalent topiramate exposure with a 26% reduction in plasma fluctuations. A multinational, Phase III, randomized, double-blind, placebo-controlled clinical trial in patients with refractory partial-onset seizures (PREVAIL) demonstrated that USL255 (200 mg/day) significantly improved seizure control and clinical outcomes versus placebo. USL255 is generally safe and well-tolerated, with a low incidence of neuropsychiatric and neurocognitive adverse events. These data suggest that USL255 may provide a useful treatment option for seizure control with convenient once-daily dosing.
Transcriptional regulation of human insulin receptor gene by the high‐mobility group protein HMGI(Y) (2001)

We have previously identified two closely related nuclear binding proteins that specifically interact with two unique functional AT-rich sequences of the 5' regulatory region of the human insulin receptor gene. Expression of these nuclear binding proteins increases during myocyte and adipocyte differentiation, and in other tissues appears to correlate with insulin receptor content. We have hypothesized, therefore, that insulin receptor expression in the insulin target tissues is regulated at least in part by these nuclear proteins. Here we show data on purification and biochemical characterization of these DNA binding proteins. Using a conventional chromatographic purification procedure combined with electrophoresis mobility shift assay and immunoblot analyses, a unique approximately 15 kDa protein, either identical to or highly related to the architectural transcription factor HMGI(Y), has now been identified, suggesting an essential role for HMGI(Y) in regulating insulin receptor gene transcription. Direct evidence of HMGI(Y) insulin receptor promoter interactions is provided by functional analysis with the CAT reporter gene and by hormone binding studies in cells expressing HMGI(Y) antisense RNA. In these experiments, antisense HMGI(Y) specifically inhibits insulin receptor promoter function and insulin receptor protein expression, indicating that HMGI(Y) is required for proper transcription of insulin receptor gene. Moreover, our data consistently support the hypothesis that a putative defect in this nuclear binding protein may cause insulin receptor dysfunction with subsequent impairment of insulin signaling and action.
Consuming Secured RESTful Services Using AngularJS (2017)

In this chapter, I will show you how Spring Boot, Spring Security, and AngularJS can work together to provide a pleasant and secure user experience. You will consume secure RESTful services using AngularJS. You will initially start by sending an authorization header with each request in AngularJS. Then you will create a login page and update the Spring Security configuration to support the login and logout authentication process.
CoCoA: Coordinated Cooperative Localization for Mobile Multi-Robot Ad Hoc Networks (2006)

Mobile robot teams are particularly suited to applications where infrastructure is unavailable or damaged since they can be used to quickly form an infrastructure-less mobile ad hoc network performing tasks in a distributed manner. In such deployment scenarios, localization of individual robots is essential for enabling many applications. In this paper, we propose CoCoA, Coordinated Cooperative localization for mobile multi-robot Ad Hoc Networks, that is low-cost, quickly deployable, energy-efficient, and provides reasonable accuracy for the applications. In CoCoA, only a subset of the robots in the mobile robot team are equipped with external localization devices (e.g. GPS, laser rangers, vision sensors). Subsequently, while robots perform their tasks, they cooperate to help localize each other without requiring static landmarks to be deployed. In addition, CoCoA coordinates the localization operations of robots to reduce energy consumption. Using detailed simulations and localization models calibrated from experimental data, we find that CoCoA is effective in reducing energy consumption while providing good localization accuracy.
Fluorescent labeling in semi-solid medium for selection of mammalian cells secreting high-levels of recombinant proteins (2009)

FLSSM allows rapid visualization of the high secretors from transfected pools prior to picking, thus eliminating the tedious task of screening a high number of cell isolates. Because of its rapidity and its simplicity, FLSSM is a versatile method for the screening of high producers for research and industry.
Precise STM spectroscopy on the superconducting phase of Bi2Sr2CaCu2O8 (1995)

We carried out electron tunnelling spectroscopy for single crystals of Bi2Sr2CaCu2O8 in the superconducting phase with use of STM. The tunnelling differential conductance curve with low noise was obtained for the cleaved surface and compared with that for the lateral surface. The two spectra were found to be essentially identical. It is concluded that tunnelling spectra obtained by our STM experiment contain contributions from every wave number and represent the total electronic density of states. From the functional form of the tunnelling conductance, the simple d wave was excluded for the symmetry of the superconducting pair wave function. The conductance curve obtained was well explained by the model, in which the gap is finite on the whole Fermi surface while it is highly anisotropic in k-space. It was suggested that the symmetry of the superconducting pair wave function is of the mixed symmetry of the s and d waves.
Increased Detection Sensitivity for KRAS Mutations Enhances the Prediction of Anti-EGFR Monoclonal Antibody Resistance in Metastatic Colorectal Cancer (2011)

The application of highly sensitive methods for the detection of KRAS mutations significantly improves the identification of mCRC patients resistant to anti-EGFR MoAbs.
Efficacy of Terminalia arjuna (Roxb.) on N-nitrosodiethylamine induced hepatocellular carcinoma in rats. (2005)

The effect of ethanolic extract of Terminalia arjuna bark on carbohydrate metabolizing enzymes of N-nitrosodiethylamine induced hepatocellular carcinoma in Wistar albino rats were studied. The plasma and liver glycolytic enzymes such as hexokinase, phosphoglucoisomerase, aldolase were significantly increased in cancer induced animals while glyconeogenic enzyme, glucose-6-phosphatase was decreased. These enzymes were reverted significantly to near normal range in treated animals after oral administration of T. arjuna for 28 days. The modulation of the enzymes constitute the depletion of energy metabolism leads to inhibition of cancer growth. This inhibitory activity may be due to the anticancer activity of constituents present in the ethanolic extract of T. arjuna.
Abstract 15967: Electrical Surrogates for Severely Reduced Left Ventricular Ejection Fraction (2016)

Introduction: Severely depressed LV systolic function is currently the most common clinical criterion for identifying patients that may benefit from the primary prevention ICD. We have previously d...
Neutralization of Errors and Attacks in Wireless Ad Hoc Networks (2005)

This paper proposes and evaluates strategies to build reliable and secure wireless ad hoc networks. Our contribution is based on the notion of inner-circle consistency, where local node interaction is used to neutralize errors/attacks at the source, both preventing errors/attacks from propagating in the network and improving the fidelity of the propagated information. We achieve this goal by combining statistical (a proposed fault-tolerant cluster algorithm) and security (threshold cryptography) techniques with application-aware checks to exploit the data/computation that is partially and naturally replicated in wireless applications. We have prototyped an inner-circle framework with the ns-2 network simulator, and we use it to demonstrate the idea of inner-circle consistency in two significant wireless scenarios: (1) the neutralization of black hole attacks in AODV networks and (2) the neutralization of sensor errors in a target detection/localization application executed over a wireless sensor network.
SAR value variation by ambient temperature of the SAR measurement system (2008)

Validating SAR values change by the ambient environmental temperature of the test room. Measured SAR value variations by the E-field probe response to the air temperature and by the electrical parameters of the human simulant liquid are analysed in this study. The prompt input of the electrical parameters of the liquid to the measurement system is important to measure SAR correctly.
The role of zonal winds in the production of a pre‐reversal enhancement in the vertical ion drift in the low latitude ionosphere (2012)

The evolution of the pre‐reversal enhancement in the vertical ion drift in the equatorial F region is described via an examination of the current systems determined from a coupled ionosphere thermosphere model. We find that the pre‐reversal enhancement is produced by a reversal in the F region zonal wind that results in an additional upward current where the E region Pedersen conductivity is declining across the dusk sector. The continuity of the total current is maintained through an enhancement in the eastward zonal current and an associated upward drift of the ions.
Towards the automatic generation and management of plant models for the validation of highly configurable cyber-physical systems (2014)

The number of cyber-physical systems is increasing considerably, being very usual in automation systems. Many cyber-physical systems must deal with variability issues to give response to the current market needs. The use of a plant model that simulates the system controlled by the embedded system might ease verification and validation activities, but building plant models manually for cyber-physical systems with many variants can be time consuming and error prone. This paper proposes a methodology that semi-automatically generates plant models in Simulink, with the main purpose of handling variability issues to validate highly configurable cyber-physical systems.
Avoided Critical Behavior inO(n)Systems (1999)

Long-range frustrating interactions, even if their strength is infinitesimal, can give rise to a dramatic proliferation of ground or near-ground states. As a consequence, the ordering temperature can exhibit a discontinuous drop as a function of the frustration. We have found this phenomenon in an entire class of models: amphiphilic systems, Mott insulators, and gauge theories of metallic glasses, to name a few.