gebhart/patrepeval huggingface dataset:
The kinin system mediates hyperalgesia through the inducible bradykinin B1 receptor subtype: evidence in various experimental animal models of type 1 and type 2 diabetic neuropathy (2006)

Both insulin-dependent (type 1) and insulin-independent (type 2) diabetes are complex disorders characterized by symptomatic glucose intolerance due to either defective insulin secretion, insulin action or both. Unchecked hyperglycemia leads to a series of complications among which is painful diabetic neuropathy, for which the kinin system has been implicated. Here, we review and compare the profile of several experimental models of type 1 and 2 diabetes (chemically induced versus gene-prone) and the incidence of diabetic neuropathy upon aging. We discuss the efficacy of selective antagonists of the inducible bradykinin B1 receptor (BKB1-R) subtype against hyperalgesia assessed by various nociceptive tests. In either gene-prone models of type 1 and 2 diabetes, the incidence of hyperalgesia mostly precedes the development of hyperglycemia. The administration of insulin, achieving euglycemia, does not reverse hyperalgesia. Treatment with a selective BKB1-R antagonist does not affect basal nociception in most normal control rats, whereas it induces a significant time- and dose-dependent attenuation of hyperalgesia, or even restores nociceptive responses, in experimental diabetic neuropathy models. Diabetic hyperalgesia is absent in streptozotocin-induced type 1 diabetic BKB1-R knockout mice. Thus, selective antagonism of the inducible BKB1-R subtype may constitute a novel and potential therapeutic approach for the treatment of painful diabetic neuropathy.
Time-of-flight range imaging for underwater applications (2018)

Precise and low-cost range imaging in underwater settings with object distances on the meter level is demonstrated. This is addressed through silicon-based time-of-flight (TOF) cameras operated with light emitting diodes (LEDs) at visible, rather than near-IR wavelengths. We find that the attainable performance depends on a variety of parameters, such as the wavelength dependent absorption of water, the emitted optical power and response times of the LEDs, or the spectral sensitivity of the TOF chip. An in-depth analysis of the interplay between the different parameters is given and the performance of underwater TOF imaging using different visible illumination wavelengths is analyzed.
Attainment of the theoretical minimum input power for injection locking of an unstable-resonator KrF laser (1981)

We report attaining a ratio of output to injected power as high as 10(8) in a KrF system, the limit being reached when injected power equals the noise per mode in the resonator. We find that, because of coherence effects, adjustment of the cavity length for correct value of the equivalent Fresnel number can change the threshold power for frequency locking by at least 2 orders of magnitude. The laser's locked bandwidth is <0.1 A, and the line can be tuned over a range exceeding 10 A. The beam divergence is near (i.e., 1.5x) the diffraction limit.
Photonic-crystal silicon-nanocluster light-emitting device (2006)

We report on enhanced light extraction from a light-emitting device based on amorphous silicon nanoclusters, suitable for very-large-scale integration, and operating at room temperature. Standard low-cost optical lithography is employed to fabricate a two-dimensional photonic crystal onto the device. We measured a vertical emission with the extracted radiation enhanced by over a factor of 4, without the aid of any buried reflector. These achievements demonstrate that a cost-effective exploitation of photonic crystals is indeed within the reach of semiconductor industry and open the way to a new generation of nanostructured silicon devices in which photonic and electronic functions are integrated together.
A Simple Method for Rapid and Precise Estimation of the Protamine Dose Required for Clinical Heparin Reversal (1989)

A simple, colorimetric protamine titration method was developed for rapid and precise estimation of the protamine dose required for clinical heparin reversal. The method employs azure A dye as the titration indicator, and has replaced the time consuming clotting assay in the conventional protamine titration method with a rapid colorimetric assay. It offers the same accuracy in estimating the protamine dose as that of the conventional titration method, but allows the processing time to be shortened to within 5 min. In a similar manner, the colorimetric assay can also be employed with a heparin titration procedure to quickly assess the heparin dose required for protamine reversal. This would allow physicians to exercise a quick and accurate heparin back-titration to patients who are overdosed with protamine.
Filter design using polynomial equations (1991)

The polynomial approach to Wiener filter design is discussed, using a simple prototype problem. An overview is also given over MSE (or H/sub 2/) filtering problems where this approach has been used. Furthermore, a new simple way of deriving the relevant polynomial equations is presented.
An introduction to physics-based animation (2020)

Physics-based animation has emerged as a core area of computer graphics finding widespread application in the film and video game industries as well as in areas such as virtual surgery, virtual reality, and training simulations. This course introduces students and practitioners to fundamental concepts in physics-based animation, placing an emphasis on breadth of coverage and providing a foundation for pursuing more advanced topics and current research in the area. The course focuses on imparting practical knowledge and intuitive understanding rather than providing detailed derivations of the underlying mathematics. The course is suitable for someone with no background in physics-based animation---the only prerequisites are basic calculus, linear algebra, and introductory physics.
Gene profiling-based phenotyping for identification of cellular parameters that contribute to fitness, stress-tolerance and virulence of Listeria monocytogenes variants (2018)

Microbial population heterogeneity allows for a differential microbial response to environmental stresses and can lead to the selection of stress resistant variants. In this study, we have used two different stress resistant variants of Listeria monocytogenes LO28 with mutations in the rpsU gene encoding ribosomal protein S21, to elucidate features that can contribute to fitness, stress-tolerance and host interaction using a comparative gene profiling and phenotyping approach. Transcriptome analysis showed that 116 genes were upregulated and 114 genes were downregulated in both rpsU variants. Upregulated genes included a major contribution of SigB-controlled genes such as intracellular acid resistance-associated glutamate decarboxylase (GAD) (gad3), genes involved in compatible solute uptake (opuC), glycerol metabolism (glpF, glpK, glpD), and virulence (inlA, inlB). Downregulated genes in the two variants involved mainly genes involved in flagella synthesis and motility. Phenotyping results of the two rpsU variants matched the gene profiling data including enhanced freezing resistance conceivably linked to compatible solute accumulation, higher glycerol utilisation rates, and better adhesion to Caco 2 cells presumably linked to higher expression of internalins. Also, bright field and electron microscopy analysis confirmed reduced flagellation of the variants. The activation of SigB-mediated stress defence offers an explanation for the multiple-stress resistant phenotype in rpsU variants.
Ejercicios para el aprendizaje de los elementos técnicos del Béisbol en la receptoría (original) (2013)

espanolLa investigacion parte de identificar una inadecuada apropiacion de los elementos tecnicos delBeisbol en el area de la receptoria, por parte de los ninos, que desaprovechan laspotencialidades del proceso de ensenanza-aprendizaje del Beisbol en las edades tempranas.Se persigue favorecer el aprendizaje de los elementos tecnicos del Beisbol en el area de lareceptoria en los ninos de nueve a diez anos, desde la elaboracion de un conjunto de ejerciciosen el municipio Colombia. El conjunto de ejercicios, brinda una mayor generacion deprocedimientos, medios dirigidos al aprendizaje de los elementos tecnicos del Beisbol en elarea de la receptoria y aspira a fortalecer el trabajo de los activistas deportivos. EnglishThe research starts identifying an inadequate appropriation of baseball technical elements in thecatcher s area, on the children s side; that waste the potentialities of Baseball teaching-learningprocess in early ages. Its pursuit is to favor the learning of Baseball technical elements, in thecatcher s area in nine to ten year children, from the elaboration of a set of exercises in Colombiamunicipality. The set of exercises, offers a greater number of procedures; means directed to thelearning of B a s e b a l l technical elements in the catcher s area and it will pretend strengthen thesport trainers activities.
Dynamic Modeling and Error Analysis of a Cable-Linkage Serial-Parallel Palletizing Robot (2020)

The efficiency and accuracy for parallel robot play a significant role in the industrial production process. In order to further improve the motion performance of parallel robot, this paper focuses on the study of mechanism design, dynamic modeling and error analysis of a cable-linkage serial-parallel palletizing robot (CSPR). Firstly, the CSPR is designed as a series-parallel hybrid mechanism driven by flexible cables, which can effectively reduce the inertia and improve the dynamic response. As is known that kinematic design optimization of compliant mechanisms requires accurate yet efficient mathematical models, the kinematics and dynamic models are established by the homogeneous coordinate transformation method and Lagrange equation. Based on the dynamic mathematical model of the robot, a variety of sensors are chosen to construct the hardware control system and the sliding mode variable structure control strategy is also designed based on motion errors. Then, the motion performance and load carrying capacity of the CSPR were analyzed and compared in different operating conditions respectively, and the results verify the validity and efficiency of the mechanism.
IRES unplugged (2016)

Cap-independent translation by IRESs can occur from various locations in mRNA [Also see Research Article by Weingarten-Gabbay et al. ]
Aldosterone blockade in post‐acute myocardial infarction heart failure (2006)

Development of heart failure (HF) or left ventricular systolic dysfunction (LVSD) significantly increases mortality post acute myocardial infarction (AMI). Aldosterone contributes to the development and progression of HF post AMI, and major guidelines now recommend aldosterone blockade in this setting. However, lack of practical experience with aldosterone blockade may make clinicians hesitant to use these therapies. This review is based on a consensus cardiology conference that occurred in May 2005 (New York City) concerning these topics. Potential barriers to the use of aldosterone blockade are discussed and an algorithm for appropriate in-hospital pharmacologic management of AMI with LVSD and/or HF is presented.
Trends in pneumonia (PNA) hospitalization among patients (pts) with chronic lymphocytic leukemia (CLL) (2009)

e20500 Background: Despite recent therapeutic advances, PNA remains a significant source of morbidity and mortality among CLL pts. We determined population-level estimates for the incidence and outcome of PNA hospitalizations. We further investigated secular trends in care by comparing cohorts before (1994) and after (2004) the widespread use of multiagent chemoimmunotherapy. Methods: Using data from the U.S. Nationwide Inpatient Sample and ICD-9CM diagnosis codes, we identified all non-governmental hospitalizations of CLL pts for a primary dx of PNA in calendar years 1994 and 2004. Admissions were described by pt demographics (age, gender, race) and comorbidity (Charlson index, presence of chronic lung disease). Ten-year prevalence estimates for CLL were obtained from NCI SEER data and used as denominators in incidence calculations. Outcomes studied included need for intubation, in-hospital mortality, and length of stay (LOS). All analyses were sample weighted. Estimates and 95% confidence limits are reported. Results: PNA was the primary dx for 7316 (13.1%) and 7651 (11.2%) CLL pt admissions in 1994 and 2004, respectively. Incidence of PNA admission was similar in 1994 (140/per 1000 pts, 95%CI 130–151) and 2004 (129/per 1000 pts, 95%CI 119–138). CLL pts admitted in 2004 were older (75.7 v. 74.2 years, p&lt;0.001) and more likely to have at least one Charlson comorbidity (67.6% v. 56.2%, p&lt;0.001) or comorbid chronic lung disease (40.6% v. 28.3%, p&lt;0.001) than pts in 1994. Intubation was rare in both cohorts (&lt;1%) and did not significantly differ by year, but in-hospital mortality was significantly higher in 2004 (11.3% v. 8.2%, p=0.005). However, LOS decreased significantly between 1994 and 2004 (9.2 v. 6.4 days, p&lt;0.001). Conclusions: PNA hospitalization rates for CLL pts have not significantly increased over the last decade despite more aggressive therapies, likely secondary to improved supportive care. However, CLL pts hospitalized for PNA are now older, increasingly likely to suffer from chronic medical illness, and significantly more likely to die while in hospital. Therapuetic strategies targeting older pts with significant comorbidities are needed. No significant financial relationships to disclose.
3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis (2021)

Obesity and type 2 diabetes are strongly associated with adipose tissue dysfunction and impaired adipogenesis. Understanding the molecular underpinnings that control adipogenesis is thus of fundamental importance for the development of novel therapeutics against metabolic disorders. However, translational approaches are hampered as current models do not accurately recapitulate adipogenesis. Here, a scaffold-free versatile 3D adipocyte culture platform with chemically defined conditions is presented in which primary human preadipocytes accurately recapitulate adipogenesis. Following differentiation, multi-omics profiling and functional tests demonstrate that 3D adipocyte cultures feature mature molecular and cellular phenotypes similar to freshly isolated mature adipocytes. Spheroids exhibit physiologically relevant gene expression signatures with 4704 differentially expressed genes compared to conventional 2D cultures (false discovery rate < 0.05), including the concerted expression of factors shaping the adipogenic niche. Furthermore, lipid profiles of >1000 lipid species closely resemble patterns of the corresponding isogenic mature adipocytes in vivo (R<sup>2</sup> = 0.97). Integration of multi-omics signatures with analyses of the activity profiles of 503 transcription factors using global promoter motif inference reveals a complex signaling network, involving YAP, Hedgehog, and TGFβ signaling, that links the organotypic microenvironment in 3D culture to the activation and reinforcement of PPARγ and CEBP activity resulting in improved adipogenesis.
Bimetallic Thermochemistry: Perturbations in M-H and M-C Bonds Due to the Presence of M' (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBimetallic Thermochemistry: Perturbations in M-H and M-C Bonds Due to the Presence of M'G. Gregg Reynolds and Emily A. CarterCite this: J. Phys. Chem. 1994, 98, 33, 8144–8153Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/j100084a037https://doi.org/10.1021/j100084a037research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Titanium Particulate Metal Matrix Composites - Reinforcement, Production Methods, and Mechanical Properties (2000)

Titanium metal matrix composites (MMCs) offer potential advantages for structural applications, where they combine the high strength, high temperature capability, and oxidation resistance of titanium with an increase in stiffness provided by the ceramic reinforcement. They have the advantage of being isotropic in behaviour, cheaper to manufacture and more amenable to subsequent processing and component forming operations. Of potential reinforcing phases for titanium, including TiB, TiB2, SiC, Al2O3, and TiC, TiB offers the best balance of stiffness, stability, and similarity of thermal expansion coefficients. The methods used to produce these Ti–TiB MMCs, such as arc melting, gas atomization, rapid solidification, and powder blending have been assessed and the benefits these composites offer over conventional titanium alloys including increased stiffness, good creep performance, fatigue resistance, and wear resistance are highlighted.
Asymmetric synthesis. Asymmetric catalytic hydrogenation using chiral chelating six-membered ring diphosphines (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric synthesis. Asymmetric catalytic hydrogenation using chiral chelating six-membered ring diphosphinesPatricia A. MacNeil, Nicholas K. Roberts, and B. BosnichCite this: J. Am. Chem. Soc. 1981, 103, 9, 2273–2280Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 May 1981https://pubs.acs.org/doi/10.1021/ja00399a023https://doi.org/10.1021/ja00399a023research-articleACS PublicationsRequest reuse permissionsArticle Views1179Altmetric-Citations171LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Magnetic Resonance Imaging for Predicting Prostate Biopsy Findings in Patients Considered for Active Surveillance of Clinically Low Risk Prostate Cancer (2012)

Adding endorectal magnetic resonance imaging to the initial clinical evaluation of men with clinically low risk prostate cancer helps predict findings on confirmatory biopsy and assess eligibility for active surveillance.
Indications for the use of diagnostic implantable and external ECG loop recorders (2009)

ECG loop recorders have a retrospective (loop) memory which continuously records and deletes the patient's ECG. They include a patient-activation function that allows the patient to activate ECG storage as a result of symptoms and an auto-activation feature that allows the capture of arrhythmic events without relying on patient compliance or perception of symptoms. Loop recorder devices can be both implantable (ILR) and external (ELR). Table 1 summarizes the characteristics of the most common diagnostic loop recorders. The retrospective memory differentiates loop recorders from prospective-only event recorders. While event recorders have some usefulness in patients with intermittent palpitations, they have no indication to detect syncope.

View this table:

Table 1 
Most common implantable and external loop recorders



Knowledge of what occurs during a spontaneous event is the ideal gold standard for evaluation. Patients with infrequent short-duration transient symptoms, recurring over weeks or months, are unlikely to be diagnosed by conventional Holter monitoring, since the likelihood of symptom-ECG correlation is very low. Consideration should be given to patient-activated event recording in such patients, but this technique has important limitations that might prevent a successful ECG recording of the event, especially for those with syncope, as it implies the activation of recording by the patients once the patient has already recovered consciousness. In such circumstances, consideration should be given to implantable and external ECG loop recorders. It is likely that loop recorders will become increasingly important, and their use will increasingly be appropriate instead of, or before, many current conventional investigations. This early loop recorder approach implies, on the one hand, the need for careful initial risk stratification in order to exclude from such a strategy patients with potential life-threatening conditions that require immediate hospitalization or intensive evaluation and treatment. On the other hand, as a general rule ECG loop recorders are indicated only when there is …