gebhart/patrepeval huggingface dataset:
Resorption von Fenoterol nach intravaginaler Applikation (1990)

Die Tokolyse mit betamimetisch wirksamen Substanzen ist bekannterweise mit zahlreichen Nebenwirkungen behaftet (2). Bei systemischer Anwendung werden nämlich neben dem Zielorgan Uterus auch eine Reihe anderer Organsysteme angesprochen.
An electron microscopic, immunogold analysis of glutamate and glutamine in terminals of rat spinocerebellar fibers (1991)

A semiquantitative, electron microscopic immunocytochemical procedure based on the use of colloidal gold particles as markers was employed to analyze the subcellular distribution of glutamate and glutamine, a major glutamate precursor, in a subpopulation of spinocerebellar mossy fiber terminals. These terminals were identified by anterograde transport of a horseradish peroxidase-wheat germ agglutinin conjugate, injected in the thoracic spinal cord. Gold particles signalling glutamate-like immunoreactivity were enriched over clusters of synaptic vesicles relative to organelle-free cytoplasmic matrix, and there was a strong positive correlation between gold particle and synaptic vesicle densities (correlation coefficient 0.94). Gold particles indicating glutamine-like immunoreactivity showed a much weaker correlation with vesicle density (correlation coefficient 0.36) and were about equally concentrated over cytoplasmic matrix as over clusters of synaptic vesicles. Compared with the mossy fibers, the putative GABAergic Golgi cell terminals exhibited a lower level of glutamate-like immunoreactivity, which was very weakly correlated with the vesicle density (correlation coefficient 0.27). The level of glutamine-like immunoreactivity in the Golgi cell terminals was similar to that in mossy fibers, but much lower than that in glial cells. The anterogradely labelled mossy fiber terminals were not enriched in immunoreactivities for aspartate or GABA. These results suggest that the level and subcellular distribution of glutamate in presumed glutamatergic terminals differs from that in terminals in which glutamate only serves metabolic or precursor roles, and that these differences can be exploited in immunocytochemical studies aimed at identifying glutamate-using neurons. In contrast, glutamine immunocytochemistry does not seem to be generally useful in this regard.
Prodrug for Bioreductive Activation-Independent Delivery of Menahydroquinone-4: Human Liver Enzymatic Activation and Its Action in Warfarin-Poisoned Human Liver. (1999)

The N,N-dimethylglycine esters of menahydroquinone-4 (1-mono, 1; 4-mono, 2; 1,4-bis, 3) were established in previous reports as prodrugs that could achieve the systemic bioreductive activation-independent delivery of menahydroquinone-4 (MKH), the active form of menaquinone-4 (MK-4), in rat. The present study was undertaken to investigate if the prodrugs could undergo cleavage to parent drug (MKH) by a human tissues enzyme catalyzed hydrolytic pathway, the mechanism of the prodrugs for vitamin K-dependent carboxylation in human liver and their action in the warfarin poisoned human liver. The hydrolysis of the esters was shown to be catalyzed by esterases located in human liver but not in human plasma. The susceptibility of the esters to undergo human liver esterase hydrolysis was affected by the esterified position: 1>2>3. By using a human liver microsomal test system, the stimulation of vitamin K-dependent carboxylation with the prodrugs was determined. The prodrug could stimulate the carboxylation activity in the absence of dithiothreitol, an artificial activator of the reductive activation pathway of MK-4. The carboxylation activity of the prodrug was strongly inhibited in the presence of eserine, an esterase inhibitor. The prodrug could also stimulate the carboxylase under warfarin-poisoned conditions, where the vitamin K cycle was strongly inhibited. The results confirmed that the prodrug could generate MKH in human liver (active site), and that the resultant MKH could act as a cofactor for the carboxylase without reductive activation processes of MK-4 to MKH. Such bioreductive activation-independent vitamin K-dependent carboxylation characteristic of the prodrug leads to enhanced pharmacological efficacy in the treatment of hypoprothrombinaemia induced in patients with coumarin and cephalosporin therapies.
Using GPS as part of an on-bus video system for bus lane enforcement (1996)

The article describes the trial of GPS (Global Positioning System) and video equipment demonstrated to the Traffic Director for London by TecnEcon and the lan Catling Consultancy (ICC) in February and March 1996. The objective of the trial was to assess the potential for using GPS equipment fitted on buses for two purposes: to provide location data which could be used to switch enforcement video cameras on and off according to the presence of the bus at a bus lane; and to provide location data on video images should they be used in any prosecution process. TecnEcon and ICC arranged for the loan by BT Research Laboratories of suitable GPS equipment for the trial. A Navstar GPS receiver was used, with the capability of accepting differential GPS. This capability was analysed using a post processing technique in which differential data was recorded at a base station at BT in Ipswich, and the data recorded on the bus was subsequently corrected using the differential data. In addition to the GPS equipment, TecnEcon provided video and computing equipment which were linked to the GPS receiver, and BT loaned an HP portable computer with software set up to record the GPS data for subsequent differential correction. The equipment was configured in order to carry out three linked demonstrations: the real time position of the bus displayed as geographic coordinate information on a video image taken by a camera at the front of the bus; the real time location of the bus on a laptop computer display showing the road network; the recording of the GPS data for subsequent differential correction. (1 page)
Rapid thawing of fresh‐frozen plasma with radio wave‐based thawing technology and effects on coagulation factors during prolonged storage at 4°C (2009)

The new radio wave technology for thawing of FFP has a significant reduction of thawing time. The impact of thawing and storage on FV, FVIII, protein S does not significantly differ between HAT and RTD.
LiNi0.5Co0.2Mn0.3O2-LiMn0.6Fe0.4PO4Mixture with Both Excellent Electrochemical Performance and Low Cost as Cathode Material for Power Lithium Ion Batteries (2018)

LiNi0.5Co0.2Mn0.3O2 (NCM) and LiMn0.6Fe0.4PO4 (LMFP) mixtures are prepared and intensively investigated in a practical level. The 18650 full batteries that are assembled with NCM-LMFP mixtures as cathodes exhibit better rate capability than cells that are utilized LMFP material as the cathode. Moreover, energy densities of 18650 batteries that are fabricated with NCM-LMFP mixtures as cathodes are not largely reduced with the reduced amount of NCM because of the high voltage plateau of LMFP material, but contrary, the cost of cathode materials is remarkably decreased. The cycling stability of batteries that are prepared with NCM-LMFP mixtures as cathodes is better than cells that are assembled with NCM as the cathode. In addition, the low/high-temperature performance of cells that are fabricated with mixture materials as cathodes is superior to batteries that are assembled with LMFP as the cathode. These electrochemical test results demonstrate that NCM-LMFP mixtures combined the advantages of the two materials, implying good synergetic effects between NCM and LMFP materials. Therefore, lithium ion batteries fabricated with NCM-LMFP mixtures as cathodes with high energy density, superior rate capability, long lifetime, excellent temperature adaptability and low cost would be a promising candidate batteries for electric vehicles.
Using handhelds and PCs together (2001)

article Share on Using handhelds and PCs together Author: Brad A. Myers Human Computer Interaction Institute, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA Human Computer Interaction Institute, School of Computer Science, Carnegie Mellon University, Pittsburgh, PAView Profile Authors Info & Claims Communications of the ACMVolume 44Issue 11Nov. 2001pp 34–41https://doi.org/10.1145/384150.384159Published:01 November 2001Publication History 141citation3,171DownloadsMetricsTotal Citations141Total Downloads3,171Last 12 Months31Last 6 weeks5 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Fundic gland polyps: three other case reports suggesting a possible association with acid suppressing therapy. (1998)

We describe three patients who developed fundic gland polyps after starting a treatment with acid suppressive agents. All three patients were treated for a long time with H2-blockers or proton pump inhibiting agents for reflux oesophagitis. In one patient the fundic gland polyps disappeared after discontinuation of the acid suppressing therapy. A possible causal role of these agents is suggested. A review of the literature about fundic gland polyps and their possible association with acid suppressive therapy and a short review about proton pump inhibiting agents and the appearance of gastric polyps in general is given.
Abstract 1009: On the role of DEAR1 as a novel ubiquitin ligase for ER alpha and predictor of tamoxifen response in ER positive breast cancer (2019)

Estrogen receptor positive (ER+) breast cancer accounts for over 70% of breast cancers. Targeted adjuvant therapies aimed at estrogen receptor have changed the natural history of the disease. However, over time many tumors develop resistance mechanisms which result in overall poor outcome. Thus, biomarkers that could predict response to antiestrogens are critically needed and would have major clinical impact. Thus, it is imperative that additional novel mechanisms be discovered not only to understand the basic underlying biology of ER alpha (ERα) signaling in order to identify genetic alterations that deregulate ERα and its role in breast cancer. DEAR1 is a tumor suppressor gene which is mutated, undergoes loss of heterozygosity in breast cancer. Previously we observed a subset of DEAR1 mutations in early onset breast cancers from premenopausal women, therefore we hypothesized that DEAR1 may function in the regulation of ERα signaling and conversely that mutations in DEAR1 (observed in human breast cancers) will abrogate that effect and could play a role in resistance to antiestrogen therapies. To test this hypothesis we studied the effect of DEAR1 expression on ERα. DEAR1 overexpression downregulated ERα expression and stability suggestive that DEAR1 may regulate ER signaling. DEAR1 interacted with ERα by immunoprecipitation and GST pulldown assays. Next we studied whether E3 ligase DEAR1 facilitates the degradation of ERα by promoting the ubiquitination of ERα. Our results indicate that DEAR1 promoted the polyubiquitination of ERα. To assess the effect of DEAR1 on estrogen mediated response, we examined the effect of DEAR1 on ERα-mediated transactivation using ERE-luciferase reporters. Results indicate that DEAR1 significantly inhibits estrogen-mediated transcriptional activity of ERα. We also studied the effect of DEAR1 in antiestrogen resistance using tamoxifen resistant cells. Preliminary results suggest that the presence of DEAR1 promoted the action of antiestrogen in tamoxifen resistant cell line. We have identified a new novel E3 ligase with regulatory effect of ERα signaling and potential implications in antiestrogen resistance.Citation Format: Seetharaman Balasenthil, Nanyue Chen, Ann Killary. On the role of DEAR1 as a novel ubiquitin ligase for ER alpha and predictor of tamoxifen response in ER positive breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1009.
Thin film luminescent solar concentrators with improved light-exposure stability (2014)

In this work, a series of crosslinked fluoropolymeric systems is presented as high durability host matrix materials for luminescent solar concentrators (LSCs). The modifications occurring to the crosslinked fluorinated films when subjected to long-term (> 1000 h) light exposure are found to correlate well with the photovoltaic response over long-term operation of functioning LSC devices. In particular, it was possible to obtain better operational stability with the new crosslinked fluorinated films compared to reference PMMA-based devices by selectively controlling the composition of the LSC thin film. The results of this study allow a greater understanding of structure-property relationships in crosslinked fluorinated films subjected to long-term weathering and provide useful guidelines for the design of high durability fluorescent systems for improved light management in the field of photovoltaics.
The Mating-induced Release of Prolactin: A Unique Neuroendrocine Response* (1983)

I. Introduction IN THE RAT, the corpus luteum is formed on the morning of estrus in response to the surge of luteinizing hormone released on the previous day, proestrus. However, unlike other mammals whose corpora lutea secrete increasing amounts of progesterone for several days (1), the newly formed corpora lutea of the rat secrete progesterone for only 2 days after formation (2, 3). In the absence of all other input, the corpora lutea subsequently fail and progesterone secretion wanes (3). It has long been appreciated that rodent corpora lutea could be maintained by either coital stimulation (4) or injection of pituitary extracts containing prolactin (PRL) activity (5, 6). An overwhelming literature now indicates that the mating stimulus induces the release of PRL which in turn “rescues” the corpora lutea of the cycle and prolongs the ability of these structures to secrete progesterone (3, 7–11). The mating stimulus or copulomimetic stimuli applied to the uterine cervix with a glass rod or appropriately...
Application of Residual Dipolar Couplings and Selective Quantitative NOE to Establish the Structures of Tetranortriterpenoids from Xylocarpus rumphii (2017)

Nine triterpenoid derivatives were isolated from the heartwood of Xylocarpus rumphii and were identified as xylorumphiins E (1), C (2), L (3), and M-R (4-9). Compounds 4-9 have a hemiacetal group in the triterpenoid side chain, making them impossible to purify. Purification was achieved after acetylation and subsequent separation of the epimeric mixtures of acetates; however differentiaition of the R and S epimers was not possible using standard NMR techniques. In one case, the relative configuration of a remotely located stereocenter with respect to the stereocenters in the main skeleton was unambiguously determined using residual dipolar couplings. Dipolar couplings were collected from the sample oriented in compressed poly(methyl methacrylate) gels swollen in CDCl<sub>3</sub>. In another case, the relative configuration was determined using 1D selective quantitative NOE experiments. Xylorumphiin K (10), xyloccensin E, taraxer-14-en-3β-ol, (22S)-hydroxytirucalla-7,24-diene-3,23-dione, and 25-hydroxy-(20S,24S)-epoxydammaran-3-one were isolated from the bark of the same plant. Compounds 3-10 are new compounds. Compounds 1-6 and xyloccensin E were tested at one concentration, 1 × 10<sup>-5</sup> M, in the NCI59 cell one-dose screen but did not show significant activity.
Cellobiose consumption uncouples extracellular glucose sensing and glucose metabolism in Saccharomyces cerevisiae (2016)

Abstract Glycolysis is central to energy metabolism in most organisms, and is highly regulated to enable optimal growth. In the yeast Saccharomyces cerevisiae , feedback mechanisms that control flux through glycolysis span transcriptional control to metabolite levels in the cell. Using a cellobiose consumption pathway, we decoupled glucose sensing from carbon utilization, revealing new modular layers of control that induce ATP consumption to drive rapid carbon fermentation. Alterations of the beta subunit of phosphofructokinase ( PFK2 ), H + -plasma membrane ATPase ( PMA1 ), and glucose sensors (SNF3, RGT2) revealed the importance of coupling extracellular glucose sensing to manage ATP levels in the cell. Controlling the upper bound of cellular ATP levels may be a general mechanism used to regulate energy levels in cells, via a regulatory network that can be uncoupled from ATP concentrations under perceived starvation conditions. Importance Living cells are fine-tuned through evolution to thrive in their native environments. Genome alterations to create organisms for specific biotechnological applications may result in unexpected and undesired phenotypes. We used a minimal synthetic biological system in the yeast Saccharomyces cerevisiae as a platform to reveal novel connections between carbon sensing, starvation conditions and energy homeostasis.
Protection Heater Development for REBCO Coils (2012)

Normal zone propagation rates are widely reported to be low in coils containing REBCO coated conductor, creating difficulties for quench protection of high field REBCO insert solenoids. A method of active quench protection using densely distributed heaters in high field REBCO coils has been proposed. When heaters are used to quench a sufficiently large fraction of the coil windings, the hot-spot temperature can be limited to acceptable values. The feasibility of protection of REBCO coils by distributed heaters depends on the amount of power to quench the required fraction of the coil volume, and the ability of the heaters to quench REBCO coils quickly. The high critical temperature of REBCO compared to low-temperature superconductor implies that the windings must be elevated significantly higher in temperature to initiate a normal zone. A number of measurements have been made of the performance of protection heaters on REBCO high field test coils. The results provide information on the response of coils to active protection heaters. Typically, there is a delay between the activation of the heater and the onset of quench in a coil. Measurements give the relation between the heater power and the quench delay time.
The circumsporozoite protein of Plasmodium: a mechanism of immune evasion by the malaria parasite? (1990)

Sporozoites of malaria are covered with a repetitive surface antigen, the circumsporozoite (CS) protein. This antigen also appears to be a major target of the host immune response. The natural immunogenicity of the CS protein has led to attempts to develop the molecule as a vaccine candidate. It seems paradoxical, however, that a successful parasite should present to the host an immunogenic surface molecule which would induce protective immunity. In this paper we suggest that the CS protein is not the target of protective immunity under natural conditions, and that naturally immunogenic repetitive antigens in malaria and other parasites have evolved as a mechanism of immune evasion, via the induction of thymus-independent B-cell responses.
Impurity-induced embrittlement of rotor steels. Volume 2. Creep embrittlement. Final report (1983)

The effects of composition and microstructure on the slow strain rate tensile (epsilon = 4.4 x 10/sup -5/ sec /sup -1/) and creep ductility have been determined for a series of high purity CrMoV steels. Four different compositions were tested: undoped (HP) material, Mn + P doped (MnP), P doped (P) and Sn doped (Sn). All samples had a tempered bainitic microstructure, a hardness of R/sub c/ 20 or 28, a grain site of ASTM 0 or 3, and some samples were step cooled prior to testing. The tensile ductility at low temperatures (below 200/sup 0/C) is controlled by the extent of cleavage fracture and at higher temperatures it is controlled by the amount of intergranular cavitation. At intermediate temperatures (approx. 500/sup 0/C) the MnP material is the most ductile, the HP and Sn material is the least ductile, and the p material has an intermediate ductility. The effects of dopants on the creep ductilities at 500/sup 0/C were the same as those observed for the tensile ductility at 500/sup 0/C. The effects of hardness on the creep ductility are due to the relative deformation rates of the grain boundaries and matrix, i.e., a lower hardness results in more intragranularmore » plasticity and a higher ductility. The effect of prior austenite grain site on creep ductility is not a grain size effect, per se, but is an effect of austenitization temperature: a higher austenitization temperature (and hence a larger grain size) lead to the dissolution of more sulfides. This results in a ductility loss due to segregated sulfur and/or fine sulfides in the grain boundaries. The effects of dopants are rationalized in terms of the effects of impurity segregation on grain boundary cavitation.« less
Incorporation of Functionalized Graphene and Its Derivates into Electrolyte: A Facile Approach to Improve the Electrochemical Performance of Lithium-Sulfur Batteries (2022)

The impending global energy crisis and the severe environmental problems in the recent years has bolstered the research for sustainable electrochemical energy storage. With the lithium-ion technology reaching its theoretical limit, lithium sulfur (Li-S) batteries have garnered extensive attention owing to their ultrahigh theoretical capacity and the low-cost, Earth abundant and environmentally friendly nature of the sulfur cathode. Despite all the advantages, the development of Li-S technology is hindered by several inherent challenges namely, the large capacity drain due to the dissolution of the intermediate polysulfides in the electrolyte leading to polysulfide shuttling and low conductivity in the cell. To overcome these issues, graphene and its derivatives have been extensively explored to mitigate polysulfide shuttling and enhance conductivity in the cell. However, at present, most of this research is limited to cathode modification which despite improving capacity retention is unable to curb the deleterious impact of polysulfide shuttling once the polysulfides dissolve in the electrolyte. In this work, we have probed the impact of implementing graphene and its derivatives as additives to the Li-S electrolyte. We have extensively characterized various commercially available rGO and graphene samples to determine their morphology, functionalization, and other key ancillary properties such as defects and ionic resistivity and have studied their impact towards the electrochemical performance of the electrolyte-modified Li-S cell. Results showed a marked improvement in initial capacity of 1323 mAh/g s and a capacity retention of 83% at 0.2 C over 105 cycles with single layer graphene additive. Further, it was shown that increasing functionalization led to improved mitigation of polysulfide shuttling and about 20% higher capacity retention (than reference) over 105 cycles. The impact of different functional groups on graphene was also probed to compare their polysulfide shuttling mitigation capacity in the electrolyte. Overall, we successfully achieved superior electrochemical performance of the Li-S cell simply by addition of graphene to the electrolyte. It was successfully shown that functionalized graphene dispersed in the electrolyte can enhance polysulfide encapsulation and improve the ionic conductivity in the cell.