gebhart/patrepeval huggingface dataset:
Hemorrhage, Impaired Hematopoiesis, and Lethality in Mouse Embryos Carrying a Targeted Disruption of the Fli1 Transcription Factor (2000)

The Ets family of transcription factors have been suggested to function as key regulators of hematopoeisis. Here we describe aberrant hematopoeisis and hemorrhaging in mouse embryos homozygous for a targeted disruption in the Ets family member, Fli1. Mutant embryos are found to hemorrhage from the dorsal aorta to the lumen of the neural tube and ventricles of the brain (hematorrhachis) on embryonic day 11.0 (E11.0) and are dead by E12.5. Histological examinations and in situ hybridization reveal disorganization of columnar epithelium and the presence of hematomas within the neuroepithelium and disruption of the basement membrane lying between this and mesenchymal tissues, both of which express Fli1 at the time of hemorrhaging. Livers from mutant embryos contain few pronormoblasts and basophilic normoblasts and have drastically reduced numbers of colony forming cells. These defects occur with complete penetrance of phenotype regardless of the genetic background (inbred B6, hybrid 129/B6, or outbred CD1) or the targeted embryonic stem cell line used for the generation of knockout lines. Taken together, these results provide in vivo evidence for the role of Fli1 in the regulation of hematopoiesis and hemostasis.
The skeleton: a multi-functional complex organ. The growth plate chondrocyte and endochondral ossification (2011)

Endochondral ossification is the process that results in both the replacement of the embryonic cartilaginous skeleton during organogenesis and the growth of long bones until adult height is achieved. Chondrocytes play a central role in this process, contributing to longitudinal growth through a combination of proliferation, extracellular matrix (ECM) secretion and hypertrophy. Terminally differentiated hypertrophic chondrocytes then die, allowing the invasion of a mixture of cells that collectively replace the cartilage tissue with bone tissue. The behaviour of growth plate chondrocytes is tightly regulated at all stages of endochondral ossification by a complex network of interactions between circulating hormones (including GH and thyroid hormone), locally produced growth factors (including Indian hedgehog, WNTs, bone morphogenetic proteins and fibroblast growth factors) and the components of the ECM secreted by the chondrocytes (including collagens, proteoglycans, thrombospondins and matrilins). In turn, chondrocytes secrete factors that regulate the behaviour of the invading bone cells, including vascular endothelial growth factor and receptor activator of NFκB ligand. This review discusses how the growth plate chondrocyte contributes to endochondral ossification, with some emphasis on recent advances.
Towards a key-free radio protocol for authentication and security of nodes and terminals in advanced waveforms (2015)

International audience
Effects of Pressure on the Azafullerene (C59N)2 Molecular Solid to 22 GPa (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTEffects of Pressure on the Azafullerene (C59N)2 Molecular Solid to 22 GPaCraig M. Brown, Ernst Beer, Cheryl Bellavia, Luigi Cristofolini, Rosario González, Michael Hanfland, Daniel Häusermann, Majid Keshavarz-K, Konstantinos Kordatos, Kosmas Prassides, and Fred WudlView Author Information School of Chemistry and Molecular Sciences University of Sussex, Brighton BN1 9QJ, U.K. The Institute for Polymers and Organic Solids University of California, Santa Barbara, California 93106 The European Synchrotron Radiation Facility B.P. 220, F-38043 Grenoble, FranceCite this: J. Am. Chem. Soc. 1996, 118, 36, 8715–8716Publication Date (Web):September 11, 1996Publication History Received18 March 1996Published online11 September 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja9608609https://doi.org/10.1021/ja9608609rapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views267Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical structure,Compressibility,Materials,Molecules,Physical and chemical processes Get e-Alerts
Evaluation of benzthiazolidine-based formamidinium salts for the synthesis of penem-type β-lactams by uncatalysed carbonylation of acyclic diaminocarbenes (2019)

Abstract The reaction of [ i Pr 2 N=CHCl]Cl with 2-phenylbenzthiazolidine (Ph-BtzH) and subsequent anion metathesis afforded the formamidinium salt [(Ph-Btz)CH(N i Pr 2 )][PF 6 ] ([ 1a H][PF 6 ]). The reaction of [ 1a H][PF 6 ] with (Me 3 Si) 2 NNa in the presence of grey selenium furnished the selenourea derivative 1a Se as trapping product of the acyclic diaminocarbene 1a . In the absence of selenium, a 2 H -1,4-benzothiazine derivative ( 2 ) was obtained, which is an isomer of 1a , whose formation is plausibly initiated by deprotonation of [ 1a H] + not at the cationic N 2 CH unit, but at the neighbouring PhCH position. CO was ineffective as trapping reagent for 1a . [ 1a H][PF 6 ], 1a Se and 2 have been structurally characterised by X-ray diffraction.
Hidden labour: the skilful work of clinical audit data collection and its implications for secondary use of data via integrated health IT (2021)

If technology is to facilitate the secondary use of healthcare data, the skilled but largely hidden labour of those who collect and recontextualise those data must be recognised. Their detailed understandings of what it takes to produce high quality data in specific contexts should inform the further development of integrated systems within organisations.
[Transient congenital hypothyroidism: physiopathology and clinica]. (1998)

The fetus and the newborn are more sensitive than adults to a reduced environmental iodine supply, and in iodine-deficient areas, transient neonatal hypothyroidism is frequently observed. This transient thyroid failure may be associated with neonatal goiter and elevated serum thyroglobulin levels at birth. Borderline elevated neonatal serum TSH concentrations frequently occur in newborns in iodine deficient areas, and result in a higher recalling rate at the screening for congenital hypothyroidism. Minor defects in mental performances and neurological development are observed in children living in areas of mild to moderate iodine deficiency, and result from the concomitant effects of iodine deficiency in the mother during pregnancy and transient neonatal hypothyroidism. Endemic cretinism is the severe and irreversible neurological consequence of iodine deficiency during fetal and neonatal life. Iodine prophylaxis is highly effective in preventing the development of iodine deficiency disorders including transient neonatal hypothyroidism. Since iodine prophylaxis in Italy is inadequate, variable degrees of iodine deficiency are still present all-over the country, and are responsible of a higher incidence of transient neonatal hypothyroidism or hyperthyrotropinemia.
The Solar Isotope Spectrometer (SIS) (1996)

The Solar Isotope Spectrometer (SIS) is scheduled for launch on NASA's Advanced Composition Explorer (ACE) mission. SIS has two solid-state telescopes that are designed to measure the elemental and isotopic composition of solar energetic particles and anomalous cosmic rays in the energy range from rv 10 to 100 Me V /nucleon, including elements from He to Zn (2≤Z≤30). This paper presents&#13;\na brief description of the design and operation of SIS.
Ion-Linear Measurements Using Six-Port Network Analyzer (1988)

The six-port junction has already proven to be very useful in small-signal measurements of multi-port networks. The aim of this paper is to demonstrate that it can also be used to determine equivalent non-linear circuit models of selected components, through measurements only at the fundamental frequency. The examples taken are packaged PIN and varactor diodes. Small-signal measurements are presented together with the plan to obtain optimized linear and non-linear models.
Synthesis and Photoluminescence of Titania Nanoparticle Arrays Templated by Block‐Copolymer Thin Films (2006)

High-density arrays of titania nanoparticles were prepared using a polystyrene-b-poly(ethylene oxide) block copolymer (PS-b-PEO) as a template and a titanium tetraisopropoxide based sol-gel precursor as titania source via a spin-coating method. The hydrophilic titania sol-gel precursor was selectively incorporated into hydrophilic PEO domains of PS-b-PEO and form titania nanoparticle arrays, due to a microphase separation between the PS block and the sol-gel/PEO phase. Field emission scanning electron microscopy (FESEM) and scanning probe microscopy (SPM) images showed that the uniformity and long-range order of the titania/PEO domains improved with increasing sol-gel precursor amount. Grazing incidence small-angle X-ray scattering (GISAXS) results indicate that the ordered structures exist over large length scales. Titania nanocrystal arrays of anatase modification were obtained by calcination at 600 degrees C for 4 h. After calcination, separated particles were observed for low and medium amounts of sol-gel precursors. Films with higher precursor amounts showed wormlike structures due to the aggregation between neighboring particles. Removal of the polymer matrix via UV treatment leads to highly ordered arrays of amorphous titania while retaining the domain size and interparticle distance initially present in the hybrid films. Photoluminescence (PL) properties were investigated for samples before and after calcination. The PL intensity increases with the increasing amount of sol-gel precursor. Bands at 412 nm were ascribed to self-trapped exitons and bands at 461 and 502 nm to oxygen vacancies, respectively. Uncalcined or UV-treated samples also showed PL properties similar to calcined samples, indicating that the local environment of the titanium atoms is similar to the environment of the crystalline anatase modification.
Adhesive capsulitis. (1987)

The signs and symptoms of adhesive capsulitis are reviewed. It is clear that this is a specific disease process distinct from those cases of "frozen shoulder." Four specific stages of the disease have been visualized at arthroscopy prior to manipulation. Stage 1 of adhesive capsulitis mimics the impingement syndrome of the shoulder.
Comparison of the blood pressure management between sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists (2022)

The cardiovascular and renal protective effects of sodium-glucose cotransporter 2 inhibitors (SGLT-2is) and glucagon-like peptide 1 receptor agonists (GLP-1Ras) are enhanced by low/controlled blood pressure (BP). However, the BP-lowering efficacy of SGLT-2is and GLP-1Ras have not been compared directly. We compared the rates of achieving target BP with SGLT-2i and GLP-1Ra treatments in Japanese patients with type 2 diabetes mellitus (T2DM). This retrospective study included 384 SGLT-2i- and 160 GLP-1Ra-treated patients with BP > 130/80 mmHg before treatment. Inverse probability weighting methods using propensity scores were used in this study. The integrated odds ratios (OR) for BP control rates were calculated and clinical changes were analyzed using a generalized linear model. SGLT-2i treatment resulted in significantly higher BP control rates than that in the GLP-1Ra treatment (integrated OR = 2.09 [1.80, 2.43]). Compared with GLP-1Ra, SGLT-2i treatment demonstrated significantly larger decreases in diastolic BP, mean arterial pressure, and body weight (- 3.8 mmHg, P = 0.006; - 4.1 mmHg, P = 0.01; and - 1.5 kg, P = 0.008, respectively) and increased annual estimated glomerular filtration rate (eGFR; 1.5 mL/min/1.73 m<sup>2</sup>/year, P = 0.04). In T2DM patients with poorly controlled BP, compared with GLP-1Ra, SGLT-2i treatment significantly improved BP management and increased eGFR.
Pour une vicariance créatrice. Entretien avec Alain Berthoz (2015)

Dans cet entretien, est abordee la thematique des realites de l’illusion a partir de l’interpretation du concept de vicariance developpe par Alain Berthoz dans l’ouvrage La Vicariance : le cerveau createur de mondes, paru en 2013 (Odile Jacob). Une succession de questions sont passees en revue : la difference entre l’illusion et l’hallucination ; la double face de la vicariance comme substitution et comme creation ; le lien de la vicariance avec les notions de diversite et d’environnement propre ; les processus creatifs en relation avec cette strategie de la vicariance ; les formes artistiques et leur complexite sous-jacente au niveau neurophysiologique ; et enfin la realite virtuelle en tant que realite vicariante ou les avatars sont des doubles qui permettent l’immersion dans ces mondes virtuels.
5′-Methylthioadenosine Nucleosidase Is Implicated in Playing a Key Role in a Modified Futalosine Pathway for Menaquinone Biosynthesis in Campylobacter jejuni (2011)

Menaquinone (vitamin K(2)) serves as an electron carrier in the electron transport chain required for respiration in many pathogenic bacteria. Most bacteria utilize a common menaquinone biosynthetic pathway as exemplified by Escherichia coli. Recently, a novel biosynthetic pathway, the futalosine pathway, was discovered in Streptomyces. Bioinformatic analysis strongly suggests that this pathway is also operative in the human pathogens Campylobacter jejuni and Helicobacter pylori. Here, we provide compelling evidence that a modified futalosine pathway is operative in C. jejuni and that it utilizes 6-amino-6-deoxyfutalosine instead of futalosine. A key step in the Streptomyces pathway involves a nucleosidase called futalosine hydrolase. The closest homolog in C. jejuni has been annotated as a 5'-methylthioadenosine nucleosidase (MTAN). We have shown that this C. jejuni enzyme has MTAN activity but negligible futalosine hydrolase activity. However, the C. jejuni MTAN is able to hydrolyze 6-amino-6-deoxyfutalosine at a rate comparable with that of its known substrates. This suggests that the adenine-containing version of futalosine is the true biosynthetic intermediate in this organism. To demonstrate this in vivo, we constructed a C. jejuni mutant strain deleted for mqnA2, which is predicted to encode for the enzyme required to synthesize 6-amino-6-deoxyfutalosine. Growth of this mutant was readily rescued by the addition of 6-amino-6-deoxyfutalosine, but not futalosine. This provides the first direct evidence that a modified futalosine pathway is operative in C. jejuni. It also highlights the tremendous versatility of the C. jejuni MTAN, which plays key roles in S-adenosylmethionine recycling, the biosynthesis of autoinducer molecules, and the biosynthesis of menaquinone.
Parsers in ML (1992)

We present the operational semantics of streams and stream matching as discussed in. Streams are data structures such as lists, but with different primitive operations. Streams not only provide an interface to usual imput/output channels, but may used as a data structure per se , holding any kind of element. A special pattern matching construct is dedicated to streams and the actual matching process will be called parsing . The primary parsing semantics that we propose here is predictive parsing, i.e. recursive descent semantics with a one token look-ahead: although this choice seems to restrict us to the recognition of LL9(1) languages, we show by examples that full functionality and parameter passing allow us to write parsers for complex languages. The operational semantics of parsers is given by transforming parsers into regular functions. We introduce a non-strict semantics of streams by translating stream expression into more classical data structures; we also investigate different sharing mechanisms for some of the stream operations.
SU-E-T-36: Comprehensive End to End Data Transfer Integrity Check of Delivery Parameters Using TrueBeam Trajectory Log Files Analysis (2012)

Purpose: Traditional manual quality assurance checks of a patient treatment plan beam parameters transfer involve visually checking the information printed from the treatment planning system against the record-and verify system for one-to-one correspondence. To provide the efficiency and accuracy of data transfer check, we have utilized the Varian TrueBeam log files which contain the complete delivery parameters. Methods: The approved plans are transferred to the Record and Verify (R&V) system, and the beams are delivered in the Truebeam Linac. The expected and actual status of TrueBeam delivery parameters are recorded during the delivery. Compared to traditional dynalog files from Varian, TrueBeam log files offer complete delivery parameters, which enable complete data transfer QA. An automatic program was designed to read the planned parameters from TPS and delivered parameters from Linac workstation. The program can verify the delivered parameters for all the external deliveries, including 3D conformal, EDW delivery, IMRT, VMAT, and electrons treatments. Results: The patient ID, beam ID, photon or electron energy, beam MU, gantry angle, couch angle, cough positions, collimator angle, jaw positions, EDW wedge angle and orientations, MLC positions, number of segments, gantry speed, dose rate, applicator size are all checked. The data transfer and/or delivery errors are flagged in the report for each type of delivery. Conclusion: The end-to-end data transfer check using TrueBeam log files provides an efficient, reliable and complete beam parameter plan check process for variety of radiation delivery technique. It is more efficient than human chart checking and improves the robustness and quality of chart checking.
Neutron Powder Diffraction Study on Highly Deuterated Ca(IO3)2.D2O (1998)

Neutron powder diffraction experiments were performed on highly deuterated calcium iodate monohydrate (bruggenite) to examine possible H/D enrichment effects. The title compound is built up of distorted CaO8 quadratic antiprisms. The iodate ions form layers parallel to (100), revealing relatively short interionic I⋯O distances of 3.02 and 2.90 Å. The water molecules are trigonally planar coordinated (2 IO3−, 1 Ca2+, site symmetry C1), forming asymmetric hydrogen bonds of different strength to adjacent iodate ions. Deviation from random distribution of the hydrogen atoms has been established.
Support for integrated value-based maintenance planning (1996)

The paper considers how IRTMM intelligent real-time maintenance management system helps process-plant engineers and owners perform value-based plant maintenance. With IRTMM, they can inspect subsystems, identify component operating parameters, and review and make notes regarding component performance or operational and maintenance history.
Synthesis and Reactions of Perylenecarboxylic Acid Derivatives, VI. Sulfonation of 3,4-Perylenedicarboximide (1979)

Abstract The sulfonation of 3,4-perylenedicarboximide (1) with sulfuric acid has been studied. The position of the sulfo group in the monosulfonated product (2) obtained at 100 °C has been discussed on the basis of the NMR and IR spectra of 2 and the related compounds, and has been confirmed to be the 9-sulfoperylene-3,4-dicarboximide. The localized treatment of 1 by H\ddotuckel and Pople MO calculations confirmed substitution at the 9-position. Paper chromatographic analysis indicated that the reaction product was only 2 in the temperature range 60–120 °C, and the reaction rate was determined spectroscopically. The maximum formation of 2 was approximatedly 97% at 100 °C. The rate of reaction was found to be a pseudo first order process and the activation energy found to be 19.5 kcal/mol.
Cardiac Arrhythmias Automated Screening Using Discrete Fractional-Order Integration Process and Meta Learning Based Intelligent Classifier (2018)

Cardiac arrhythmias reveal multiple morphologies in time-domain waveforms. Abnormal beats reflect the origin and the conduction path of the ectopic heart activation pulses, including supraventricular, junctional, and ventricular arrhythmias and conduction abnormalities. This paper proposes a method for automated screening of cardiac arrhythmias using the discrete fractional-order integration (DFOI) and the meta-learning-based intelligent classifier. The DFOI process with the specific fractional order is used to extract the QRS features with the finite computations. It can deal with the irregular time-varying signals. The meta-learning-based intelligent classifier is used to identify the abnormal classes, consisting of a primary multilayer network and several agent networks. Since abnormal QRS complexes are multi-waveforms such as ventricular premature contraction, the classifier needs to retrain with new training patterns for meeting new condition in clinical applications. Thus, this model possesses the learning-to-optimization capability for retraining generalized regression neural network using the particle swarm optimization algorithm. Using incremental new training patterns, each inducer is used to track the past learning experiences through several agent networks. This pattern scheme can gradually enhance the accuracy by refining the optimal parameters of each sub-estimator for pattern recognition. Using the arrhythmia database of the Massachusetts Institute of Technology-Beth Israel Hospital (MIT-BIH) database, the proposed intelligent classifier demonstrated greater efficiency and promising results in average accuracy, positive predictivity, and true negative rate for recognizing electrocardiography signals.
Identification of a biliary metabolite of cisapride (1988)

Radiolabeled cisapride was administered orally to male Wistar rats. The drug was metabolized extensively, resulting in the formation of a large number of urinary and faecal metabolites. In bile-cannulated rats a major metabolite was excreted with the bile whose structure could not be elucidated with the aid of the registered electron impact and desorption chemical ionization spectra. Therefore the biliary metabolite was subjected to extensive analytical procedures combining fast atom bombardment mass spectrometry, thermospray liquid chromatography/mass spectrometry, nuclear magnetic resonance and ultraviolet analysis. The results of this study allowed the identification of the biliary metabolite as the O-sulphate of metabolically formed 3'-hydroxy-cisapride.