gebhart/patrepeval huggingface dataset:
Palladium-Alloy Membrane Reactors for Fuel Reforming and Hydrogen Production: A Review (2021)

Hydrogen has a potential to be a clean energy carrier that emits only water after combustion and can be produced from diverse feedstocks. Hydrogen has much better combustion characteristics in conventional combustion systems and higher energy efficiency when used with fuel cells. More than 75 million tons of hydrogen are currently produced primarily using fossil fuels as feedstock via steam methane reforming processes. Steam methane reforming is the mature technology for producing hydrogen and when coupled with CO2 capture can help address climate challenges. Inorganic palladium (Pd) membranes have demonstrated great potential to separate hydrogen due to their stability and high selectivity for hydrogen. In this review, several methods of fabricating Pd-alloy membranes are discussed and compared in terms of membrane stability and selectivity of hydrogen. Such methods include electroless plating (ELP), chemical vapor deposition (CVD), physical vapor deposition (PVD), and electroplating deposition (EPD). The permeability of hydrogen in different Pd-based alloy membranes are presented and compared. Focus has been made, in this review, on Pd–Ag, Pd–Cu, Pd–Au, and Pd–Ru alloys. The effects of impurities (H2S, CO, O2, and CO2) on performance of different Pd-based alloy membranes are also investigated. Moreover, the subject of using Pd-membrane reactors for fuel reforming and H2 production is investigated in detail based on numerous experimental and numerical studies in the literature, considering different membrane reactor designs: axial-flow tubular, radial-flow tubular, axial-flow spherical, packed-bed, fluidized bed, and slurry bubble column. The performance of Pd-membranes in such reactors for hydrogen production is compared, and the effects of temperature, pressure, H2O/CH4 ratio, and residence time on reformer performance are also investigated. Finally, the use of computational methods, particularly, density functional theory (DFT), to complement well-established experimental methods for studying the diffusion of H and its isotopes in different metals is reviewed. The review concludes with some insights into future work to bring Pd-membrane reactors to the level required for hydrogen production at the commercial level.
Origin and movement of groundwater and major ions in a thick deposit of Champlain Sea clay near Montréal (1989)

At a site near Montréal, piezometers and core samples were used to assess the origin, age, and rate of groundwater movement in a 28 m thick deposit of Champlain Sea clay. 3 H occurs only within the upper 3–4 m, which indicates that groundwater below this surficial weathered zone originated prior to 1952. Concentrations of 18 O, Na + , and Cl − in water from the deepest piezometer suggest that the deep clay was deposited in a mixture of about 33% seawater and 67% freshwater. Profiles of several major ions show a gradual increase in concentration with depth. Mathematical simulations of vertical migration of Ca 2+ , Mg 2+ , K + , Na + , and Cl − provide close matches to the field profiles when only upward diffusion of these ions into the surficial freshwater zone is included in the model with a diffusion time of approximately 10 000 a. When the downward advection rate of 0.13 cm ∙ a −1 obtained from field measurements of hydraulic gradient and hydraulic conductivity is included in the model, the simulated major-ion profiles deviate markedly from the field profiles. This suggests that the hydraulic gradient in the clay is less than the threshold gradient necessary to cause Darcian flow. This study suggests that, in areas where clayey Champlain Sea deposits are thick, opportunities exist for locating waste disposal facilities that would have no significant potential for causing contamination of groundwater resources beneath the clay. Key words: groundwater, permeability, diffusion, environmental isotopes, threshold gradient, geochemistry, subsurface waste disposal.
In situ solid state formation of copper(I) coordination polymers by thermal reduction of copper(II) precursor compounds: structure and reactivity of [Cu(NCS)2(pyrimidine)2]n (2009)

Reaction of copper(II) thiocyanate with pyrimidine leads to the formation of the new ligand-rich 1:2 (1:2 = ratio metal salt to ligand) copper(II) compound [Cu(NCS)(2)(pyrimidine)(2)](n) (1). Its crystal structure was determined by X-ray single crystal investigations. It consists of linear polymeric chains, in which the Cu(2+) cations are mu-1,3 bridged by the thiocyanato anions. The pyrimidine ligands are terminal N-bonded to the Cu(2+) cations, which are overall octahedrally coordinated by two pyrimidine ligands and two N-bonded as well as two S-bonded thiocyanato anions. Magnetic measurements were preformed yielding weak net ferromagnetic interactions between adjacent Cu(2+) centers mediated by the long Cu-S distances and/or interchain effects. On heating compound 1 to approx. 160 degrees C, two thirds of the ligands are discharged, leading to a new intermediate compound, which was identified as the ligand-deficient 2:1 copper(I) compound [(CuNCS)(2)(pyrimidine)](n) by X-ray powder diffraction. Consequently, copper(II) was reduced in situ to copper(I) on heating, forming polythiocyanogen as byproduct. Elemental analysis and infrared spectroscopic investigations confirm this reaction pathway. Further investigations on other ligand-rich copper(II) thiocyanato compounds clearly show that this in situ thermal solid state reduction works in general.
Anti–CTLA-4 therapy requires an Fc domain for efficacy (2018)

Ipilimumab, a monoclonal antibody that recognizes cytotoxic T lymphocyte antigen (CTLA)-4, was the first approved "checkpoint"-blocking anticancer therapy. In mouse tumor models, the response to antibodies against CTLA-4 depends entirely on expression of the Fcγ receptor (FcγR), which may facilitate antibody-dependent cellular phagocytosis, but the contribution of simple CTLA-4 blockade remains unknown. To understand the role of CTLA-4 blockade in the complete absence of Fc-dependent functions, we developed H11, a high-affinity alpaca heavy chain-only antibody fragment (VHH) against CTLA-4. The VHH H11 lacks an Fc portion, binds monovalently to CTLA-4, and inhibits interactions between CTLA-4 and its ligand by occluding the ligand-binding motif on CTLA-4 as shown crystallographically. We used H11 to visualize CTLA-4 expression in vivo using whole-animal immuno-PET, finding that surface-accessible CTLA-4 is largely confined to the tumor microenvironment. Despite this, H11-mediated CTLA-4 blockade has minimal effects on antitumor responses. Installation of the murine IgG2a constant region on H11 dramatically enhances its antitumor response. Coadministration of the monovalent H11 VHH blocks the efficacy of a full-sized therapeutic antibody. We were thus able to demonstrate that CTLA-4-binding antibodies require an Fc domain for antitumor effect.
Development of a competitive exclusion product for chicken meeting the regulatory requirements for registration in the EU. (2005)

Development of a competitive exclusion product for chicken meeting the regulatory requirements for registration in the EU R. Plail , V. Klose , M. Mohnl , D. Jolli , A. Klimitsch , G. Schatzmayr, A.P. Loibner , University of Natural Resources and Applied Life Sciences, Interuniversity Department for Agrobiotechnology, A-3430 Tulln, Konrad Lorenzstrasse 20, 2 Biomin GmbH, A-3130 Herzogenburg, Industriestrasse 21. E-mail: regina.plail@boku.ac.at
Protist diversity and community complexity in the rhizosphere of switchgrass are dynamic as plants develop (2021)

We demonstrate that environmental filtering is a dominant determinant of overall protist community properties and that at the rhizosphere level, plant control on the physical and biological environment is a critical driver of protist community composition and dynamics. Since protists are key contributors to plant nutrient availability and bacterial community composition and abundance, mapping and understanding their patterns in rhizosphere soil is foundational to understanding the ecology of the root-microbe-soil system. Video Abstract.
Collective clog control: Optimizing traffic flow in confined biological and robophysical excavation (2018)

Groups of interacting active particles, insects, or humans can form clusters that hinder the goals of the collective; therefore, development of robust strategies for control of such clogs is essential, particularly in confined environments. Our biological and robophysical excavation experiments, supported by computational and theoretical models, reveal that digging performance can be robustly optimized within the constraints of narrow tunnels by individual idleness and retreating. Tools from the study of dense particulate ensembles elucidate how idleness reduces the frequency of flow-stopping clogs and how selective retreating reduces cluster dissolution time for the rare clusters that still occur. Our results point to strategies by which dense active matter and swarms can become task capable without sophisticated sensing, planning, and global control of the collective.
Severe thrombocytopenia before liver transplantation is associated with delayed recovery of thrombocytopenia regardless of donor type (2008)

Our study suggests that severe thrombocytopenia before transplant is closely associated with delayed recovery of platelet count after transplant and donor type did not affect the recovery of thrombocytopenia. The reappearance of thrombocytopenia after transplant should be considered a possible indicator of flow disturbance in the portal vein.
Backwards Compatible 3D Audio Conference Server Using HRTF Synthesis and SIP (2011)

This paper describes an integration of a 3D sound convolution engine into a telephone conference server software. Our system virtually places participants of a telephone conference to different positions around the listeners by using Head Related Transfer Functions (HRTFs), which helps to identify active speakers in an audio conference. Intelligibility of communication is also increased by making use of the cocktail party effect which helps to concentrate on one specific participant, even if there are more simultaneously active speakers. To support regular telephone systems, we focus in particular on compatibility to existing Voice over IP (VoIP) infrastructure by using standardized protocols like the Session Initiation Protocol (SIP) and the Real-Time Transport Protocol (RTP). Both traditional telephone devices and software clients are put into one heterogeneous conference. While the conference server transmits the down-mixed, mono single-channel conference signal to regular phones, the software clients can receive a stereo-signal enabling full 3D audio.
Development and Application of a Rheological Method to Investigate Crystallization of Palm Oil (2019)

Abstract Structuring of fatty products is important in producing palatable food products. Saturated fat (SAFA) crystals are needed to bring structure to many products (such as bakery or confectionery). In a product control of the structure by fat nucleation and crystallization, it is important to deliver the correct performance. Many techniques only work on quiescent systems and give limited information about the sheared systems that are generally found in industrial production of products. This article presents a novel rheological technique that can be used to probe crystallization and network structure under sheared conditions. The results show that crystallization of palm oil can be divided into different key stages. These result from initial nucleation, structuring by the crystals, polymorphic transformation, further structure building, and then subsequent relaxation. Significant postcrystallization (sintering) events occur over at least a day. It is seen that the shear rate leads to possibilities for crystallization control. Higher shear gives a reduction in network strength (as measured by G′) of the initial crystal network. However, after longer posthardening, results are very similar. This work enables the development of a fast tool that can be used to monitor structure formation in fats and reveals the relative importance of the nucleation–crystallization and postcrystallization events in sheared systems.
Deposition of bone‐like apatite on silk fiber in a solution that mimics extracellular fluid (2003)

The fabrication of apatite-organic polymer hybrids is one of several attractive methods for the development of biomaterials as a substitute for bone. Such materials have both bone-bonding ability and mechanical properties analogous to natural bone. The biomimetic process has focused attention on fabricating such hybrids, where bone-like apatite is deposited on an organic polymer surface in solutions that mimic physiological conditions. In this process, a bone-like apatite layer can be coated onto organic substrates either by using a simulated body fluid (SBF) with ion concentrations nearly equal to those of human extracellular fluid, or by using fluids that are supersaturated with respect to apatite at ambient conditions. In this study, we investigated the ability of natural silk and its related materials to facilitate apatite deposition under biomimetic conditions. Cloths made of raw silk or normal silk fibers were soaked in 1.5SBF, which has 1.5 times the ion concentration of SBF. Sericin film, which is made from an extract of degummed raw silk, was soaked in 1.5SBF. The cloth and the film soaked in 1.5SBF then were characterized by scanning electron microscopic (SEM) observation, energy dispersive X-ray microanalysis (EDX), and thin-film X-ray diffraction (TF-XRD). Apatite deposition was observed on the surface of cloth made from raw silk fiber after it was soaked in 1.5SBF, but it was not observed on cloth made from normal silk fibers. The apatite deposition on the raw silk fiber cloth was accelerated when the fibers were subjected to treatment with CaCl(2) solution at a concentration of at least 1 kmol/m(3) before immersion in 1.5SBF. Apatite deposition also was observed on the sericin film after the film was soaked in 1.5SBF for 7 days. These results indicate that apatite deposition on raw silk cloth is attributable to the catalytic effect of sericin because the surface of raw silk consists of sericin whereas that of normal silk contains fibroin. The deposition of the apatite and its crystal growth are accelerated by the presence of calcium ions on the sericin after treatment with CaCl(2) solution. Thus, sericin on natural silk fiber has the potential to facilitate apatite deposition and can be useful as a polymer material in the fabrication of hybrid materials analogous to bone through biomimetic processes.
Chapter Green Nanotechnology: Development of Nanomaterials for Environmental and Energy Applications (2013)

This book chapter discusses the syntheses of various nanomaterials, for green nanotechnology applications in detail. Special attention is given to the development of emerging areas, such as environmental as well as energy materials. Various approaches for preparing nanostructured photocatalysts, such as titanium dioxide, zinc oxide, iron oxide, and metal sulfides, different conventional methods and novel methods, including sol-gel methods, hydrothermal methods, microwave-assisted methods and sonochemical methods are introduced. The use of nanomaterials as photocatalysts, supporting materials for solar cells, and disinfectants is reported for environmental remediation and energy applications. Advanced applications of nanomaterials for water detoxification, air purification, and the inactivation of pathogenic microorganisms in water as well as dye-sensitized solar cells is also discussed. The enhancement of selectivity of photocatalysis, especially TiO2 systems, for the destruction of target contaminants in water is comprehensively presented. Finally, the role of reactive oxygen species (ROS), such as hydroxyl radical (•OH), superoxide anion radical (O2 •-), singlet oxygen (1O2) and hydrogen peroxide (H2O2), in semiconductor photocatalysis is introduced and various experimental techniques to detect ROS are also discussed.
A Novel Digital Control Technique for Brushless DC Motor Drives (2007)

Brushless DC (BLDC) motor drives are continually gaining popularity in motion control applications. Therefore, it is necessary to have a low cost, but effective BLDC motor speed/torque regulator. This paper introduces a novel concept for digital control of trapezoidal BLDC motors. The digital controller was implemented via two different methods, namely conduction-angle control and current-mode control. Motor operation is allowed only at two operating points or states. Alternating between the two operating points results in an average operating point that produces an average operating speed. The controller design equations are derived from Newton's second law. The novel controller is verified via computer simulations and an experimental demonstration is carried out with the rapid prototyping and real-time interface system dSPACE.
Hemodynamic forces induce the expression of heme oxygenase in cultured vascular smooth muscle cells. (1997)

Both nitric oxide (NO) and carbon monoxide (CO) are vessel wall-derived messenger molecules that cause platelet inhibition and vasodilation by activating guanylyl cyclase in target cells. Since vascular smooth muscle cells (SMCs) are exposed to shear and tensile stresses, this study examined the effects of these hemodynamic forces on the enzymes that generate NO and CO in SMCs. Monolayers of cultured rat aortic SMCs were subjected to shear stress using a modified cone and plate viscometer, or cyclic elongational stretch using a compliant silastic culture membrane. Shear stress stimulated time-dependent increases in mRNA and protein for inducible heme oxygenase-1 (HO-1), the enzyme which forms CO as a byproduct of heme degradation. The threshold level of shear necessary to induce HO-1 expression was between 5 and 10 dynes/cm2. In contrast, shear stress did not stimulate inducible NO synthase (iNOS) expression. Cyclic stretch also induced the expression of HO-1 but not of iNOS mRNA. Exposure of vascular SMCs to shear stress stimulated the production and release of CO as demonstrated by the CO-dependent increase in intracellular cGMP levels in coincubated platelets. In addition, ADP-stimulated aggregation was inhibited in platelets exposed to sheared SMCs but not in platelets exposed to untreated control SMCs. Treatment of sheared SMCs with the HO-1 inhibitor, tin protoporphyrin-IX, blocked the antiaggregatory effect of the cells, whereas the iNOS inhibitor, methyl--arginine, had no effect. These results indicate that hemodynamic forces induce HO-1 gene expression and CO production in vascular SMCs, and that SMC-derived CO inhibits platelet aggregation. Thus, CO is a novel endogenous vessel wall-derived messenger molecule that may be selectively induced by hemodynamic forces to inhibit platelet reactivity and preserve blood fluidity at sites of vascular injury.
Striatal Delivery of Neurturin by CERE-120, an AAV2 Vector for the Treatment of Dopaminergic Neuron Degeneration in Parkinson's Disease (2006)

Glial cell line-derived neurotrophic factor (GDNF) or its naturally occurring analog, neurturin (NTN), can potentially improve the function and delay the rate of degeneration of dopaminergic neurons in Parkinson's disease (PD). However, their delivery to the central nervous system has proven to be a significant challenge. Viral vector-mediated gene transfer offers a practical means to continuously supply neurotrophic factors in targeted areas of the brain. CERE-120 is an adeno-associated viral vector encoding NTN, developed for the treatment of PD. We found that the kinetics and pattern of NTN expression in the rat striatum following injection of CERE-120 is rapid, increases significantly up to 4 weeks, and exhibits a stable volume of distribution thereafter for at least 1 year, the longest time-point evaluated. Quantitative enzyme-linked immunosorbent assay confirmed that steady-state levels are maintained from 4 weeks onward. We demonstrated that NTN volume of distribution can be controlled by varying the dose of vector injected and that NTN delivered via CERE-120 was bioactive, as evidenced by the neuroprotection of DA neurons in the rat 6-hydroxydopamine lesion model. These data provided the foundation for further non-clinical development of CERE-120, leading to an ongoing clinical trial in PD patients.
Optimization of Aeroengine Shop Visit Decisions Based on Remaining Useful Life and Stochastic Repair Time (2016)

Considering the wide application of condition-based maintenance in aeroengine maintenance practice, it becomes possible for aeroengines to carry out their preventive maintenance in just-in-time (JIT) manner by reasonably planning their shop visits (SVs). In this study, an approach is proposed to make aeroengine SV decisions following the concept of JIT. Firstly, a state space model (SSM) for aeroengine based on exhaust gas temperature margin is developed to predict the remaining useful life (RUL) of aeroengine. Secondly, the effect of SV decisions on risk and service level (SL) is analyzed, and an optimization of the aeroengine SV decisions based on RUL and stochastic repair time is performed to carry out JIT manner with the requirement of safety and SL. Finally, a case study considering two CFM-56 aeroengines is presented to demonstrate the proposed approach. The results show that predictive accuracy of RUL with SSM is higher than with linear regression, and the process of SV decisions is simple and feasible for airlines to improve the inventory management level of their aeroengines.
Hematologic Recovery and Survival of Lymphoma Patients After Autologous Stem-Cell Transplantation: Comparison of Bone Marrow and Peripheral Blood Progenitor Cells (1996)

Autologous stem-cell transplantation is widely used as part of the treatment of poor prognosis lymphoma patients. Since 1986, peripheral blood progenitor cells (PBPC) mobilized by chemotherapy and/or hematopoietic growth factors have progressively been used instead of autologous bone marrow (BM) cells. Toxicity, engraftment and long-term outcome were compared in a population of relapsing or refractory lymphoma patients given high-dose therapy. During 1986 to 1993, 150 patients with refractory or relapsed non-Hodgkin's lymphomas (n = 93) or Hodgkin's disease (n = 57) received intensive therapy followed by the reinjection of BM (n = 72) or PBPC (n = 78). PBPC were collected by aphereses during the phase of hematologic recovery after mobilization by chemotherapy alone (n = 36) or associated with GCSF (n = 43). Conditioning regimens included chemotherapy alone in 77%, associated with total body irradiation (TBI) in 23%. After stem-cell reinfusion, 55% of the PBPC group received GCSF versus 24% in the BM group. Results show that the median time to neutrophil counts > 500/microliters and platelets > 50,000/microliters was significantly shorter in the PBPC than the BM group, respectively 13 versus 23 days and 18 versus 26 days (P < 0.05). This difference remained significant (P < 0.05) when patients were stratified according to the administration or not of GCSF after transplantation. PBPC grafting after high-dose therapy was associated with a median reduction of the hospital stay of 10 days. The majority of patients (90%) maintained normal blood counts at 3 months, and no secondary graft failure was observed in either group. The use of TBI in the conditioning regimen was the only significant factor affecting long-term hematologic recovery. For relapsing patients with histologically aggressive lymphomas, overall survival and failure-free survival were similar in both groups. In conclusion, PBPC transplantation is a safe procedure associated with improvement of hematopoietic recovery and a shortened hospital stay.