gebhart/patrepeval huggingface dataset:
mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex (2020)

Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the developing human cortex that contribute to its cellular diversity and evolutionary expansion. The mammalian Target of Rapamycin (mTOR) signaling pathway is active in human oRG cells. Mutations in mTOR pathway genes are linked to a variety of neurodevelopmental disorders and malformations of cortical development. We find that dysregulation of mTOR signaling specifically affects oRG cells, but not other progenitor types, by changing the actin cytoskeleton through the activity of the Rho-GTPase, CDC42. These effects change oRG cellular morphology, migration, and mitotic behavior, but do not affect proliferation or cell fate. Thus, mTOR signaling can regulate the architecture of the developing human cortex by maintaining the cytoskeletal organization of oRG cells and the radial glia scaffold. Our study provides insight into how mTOR dysregulation may contribute to neurodevelopmental disease.
Pathogenetic Mechanisms in Vasculitis, I: Anti-Neutrophil Cytoplasm Antibody (ANCA) Stimulates UN-Primed Neutrophils (1991)

Conference Abstract| March 01 1991 Pathogenetic Mechanisms in Vasculitis, I: Anti-Neutrophil Cytoplasm Antibody (ANCA) Stimulates UN-Primed Neutrophils MT Keogan; MT Keogan 1Department of Clinical Immunology, Addenbrooke's Hospital, Cambridge Search for other works by this author on: This Site PubMed Google Scholar VLM Esnault; VLM Esnault *Department of Medicine, University of Cambridge, England Search for other works by this author on: This Site PubMed Google Scholar AJ Green; AJ Green *Department of Medicine, University of Cambridge, England Search for other works by this author on: This Site PubMed Google Scholar CM Lockwood; CM Lockwood *Department of Medicine, University of Cambridge, England Search for other works by this author on: This Site PubMed Google Scholar DL Brown DL Brown 1Department of Clinical Immunology, Addenbrooke's Hospital, Cambridge Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1991) 80 (s24): 33P. https://doi.org/10.1042/cs080033Pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation MT Keogan, VLM Esnault, AJ Green, CM Lockwood, DL Brown; Pathogenetic Mechanisms in Vasculitis, I: Anti-Neutrophil Cytoplasm Antibody (ANCA) Stimulates UN-Primed Neutrophils. Clin Sci (Lond) 1 March 1991; 80 (s24): 33P. doi: https://doi.org/10.1042/cs080033Pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1991 The Biochemical Society and the Medical Research Society1991 Article PDF first page preview Close Modal You do not currently have access to this content.
Cache-Assisted Collaborative Task Offloading and Resource Allocation Strategy: A Metareinforcement Learning Approach (2022)

Multiaccess edge computing (MEC) provides users with better Quality of Experience (QoE) via offloading tasks to the nearby edge. However, the emergence of new Internet of Things applications with multiple tasks and repeated requests brings redundant computation and transmission to the edge. Meanwhile, the current offloading method based on deep reinforcement learning (DRL) has low sampling efficiency and slow convergence issues for training in a changing environment. Therefore, improving QoE of computation offloading services is still the ultimate challenge. In this article, we devise a collaboration of computing and cache resources among multiple edge nodes, which could reduce redundant computation and transmission. Specifically, we formulate a cache-assisted computation offloading process as a QoE-aware utility maximization problem based on multidimensional indicators. Then, we propose a cache-assisted collaborative task offloading and resource allocation strategy to solve it. This strategy is decomposed into two subproblems. First, to determine and obtain task cache state, we propose a collaborative task caching algorithm, which can improve the hit rate of tasks while balancing network overhead. Second, to acquire offloading and resource allocation decisions efficiently, we propose a metareinforcement learning-based cache-assisted computation offloading method (MCCOM), which can achieve rapid offloading decisions with a few gradient updates and samples. The optimization problem was transformed into multiple Markov decision processes (multiple MDPs). The improved learning process includes metapolicy learning that adapts to multiple Markov decision processes (MDPs) and policy learning for a specific MDP based on metapolicy. Simulation results show that our proposed method outperforms baselines in terms of QoE indicators while achieving rapid convergence and decisions.
Extracellular Protein Kinase A Modulates Intracellular Calcium/Calmodulin-Dependent Protein Kinase II, Nitric Oxide Synthase, and the Glutamate–Nitric Oxide–cGMP Pathway in Cerebellum. Differential Effects in Hyperammonemia (2016)

Extracellular protein kinases, including cAMP-dependent protein kinase (PKA), modulate neuronal functions including N-methyl-d-aspartate (NMDA) receptor-dependent long-term potentiation. NMDA receptor activation increases calcium, which binds to calmodulin and activates nitric oxide synthase (NOS), increasing nitric oxide (NO), which activates guanylate cyclase, increasing cGMP, which is released to the extracellular fluid, allowing analysis of this glutamate-NO-cGMP pathway in vivo by microdialysis. The function of this pathway is impaired in hyperammonemic rats. The aims of this work were to assess (1) whether the glutamate-NO-cGMP pathway is modulated in cerebellum in vivo by an extracellular PKA, (2) the role of phosphorylation and activity of calcium/calmodulin-dependent protein kinase II (CaMKII) and NOS in the pathway modulation by extracellular PKA, and (3) whether the effects are different in hyperammonemic and control rats. The pathway was analyzed by in vivo microdialysis. The role of extracellular PKA was analyzed by inhibiting it with a membrane-impermeable inhibitor. The mechanisms involved were analyzed in freshly isolated cerebellar slices from control and hyperammonemic rats. In control rats, inhibiting extracellular PKA reduces the glutamate-NO-cGMP pathway function in vivo. This is due to reduction of CaMKII phosphorylation and activity, which reduces NOS phosphorylation at Ser1417 and NOS activity, resulting in reduced guanylate cyclase activation and cGMP formation. In hyperammonemic rats, under basal conditions, CaMKII phosphorylation and activity are increased, increasing NOS phosphorylation at Ser847, which reduces NOS activity, guanylate cyclase activation, and cGMP. Inhibiting extracellular PKA in hyperammonemic rats normalizes CaMKII phosphorylation and activity, NOS phosphorylation, NOS activity, and cGMP, restoring normal function of the pathway.
Improving authentication performance of distributed SIP proxies (2009)

The performance of SIP proxies is critical for the robust operation of many applications. However, the use of even light-weight authentication schemes can significantly degrade throughput in these systems. In particular, systems in which multiple proxies share a remote authentication database can experience reduced performance due to latency. In this paper, we investigate how the application of parallel execution and batching can be used to maximize throughput while carefully balancing demands for bandwidth and call failure rates. Through the use of a modified version of OpenSER, a high-performance SIP proxy, we demonstrate that the traditional recommendation of simply launching a large number of parallel processes not only incurs substantial overhead and increases dropped calls, but can actually decrease call throughput. An alternative technique that we implement, request batching, fails to achieve similarly high proxy throughput. Through a carefully selected mix of batching and parallelization, we reduce the bandwidth required to maximize authenticated signaling throughput by the proxy by more than 75%. This mix also keeps the call loss rates below 1% at peak performance. Through this, we significantly reduce the cost and increase the throughput of authentication for large-scale networks supporting SIP applications.
Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H3 (2018)

Our novel ELISA provides reproducible measurements of histone H3 levels. Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner. Further studies are needed to evaluate the clinical utility of histone H3 levels in patients with sepsis.
Continuous, self-sustaining smouldering destruction of simulated faeces (2016)

A new approach for the rapid destruction of human waste using smouldering combustion is presented. Recently, self-sustaining smouldering combustion was shown to destroy the organic component of simulated human solid waste and dog faeces resulting in the sanitization of all pathogens using a batch process (Yermán et al., 2015). Here, a continuous smouldering process is demonstrated for the first time, allowing for a much smaller reactor size and much less energy input per mass of waste treated. The self-sustained smouldering of simulated human faeces mixed with sand is evaluated over long periods (more than 16 h) based on a single ignition. The key process of intermittent self-sustained smouldering, in which the reaction is terminated and restarted by only turning the air off and on, is demonstrated. Experiments examine the influence of two key operator controls: airflow rate and set elevation of the quasi-steady-state smouldering front in a 37 cm high reactor. Quasi-steady-state fuel destruction rates from 93 g/h to 12 g/h were achieved by varying the superficial flow velocity from 7.4 cm/s to 0.11 cm/s, the latter with a velocity approximately an order of magnitude lower than possible for a self-sustaining reaction in an equivalent batch system. Excess energy of up to 140 J/g of sand was recovered from the clean sand produced in each cycle, which could be used to further increase the energy efficiency of this novel waste treatment system.
A review of virtual reality and haptics for product assembly (part 1): rigid parts (2013)

Purpose Virtual reality (VR) for product assembly has been studied for more than 20 years but its practical application in industry is still very much in its infancy. Haptics is a new and important interaction method for VR and a strong and growing research area, however, it still remains a virtually unknown concept for industrial application. Design/methodology/approach This paper provides a comprehensive survey of VR and haptics for product assembly, from rigid parts to soft cables. Findings Some new ideas and research progresses in recent years are especially investigated. First the concepts and classifications of virtual assembly are introduced and the different virtual environment systems for product assembly are discussed. Then the major research groups, typical systems and major research issues are explored in detail, treating rigid parts and soft cables separately. Lastly, the barriers preventing successful application of virtual assembly are discussed and future research directions are also summarized. Originality/value The paper provides an overview and analysis of VR and haptics for product assembly, including both rigid parts and soft cables.
Design of IoT and ML enabled Framework for Water Quality Monitoring (2022)

Globally, the quality of water is declining due to multiple factors such as urbanization, industrialization, agricultural waste disposal, climatic and seasonal variations. As per a study conducted by the World Health Organization (WHO), around 144 million people in the world directly collect and consume untreated surface water from ponds, lakes, rivers, and streams. One key challenge is that the community members are unaware of the dynamic variations in water quality and its impacts on their health, and this demands the need for systems and processes that would provide the opportunity for community members to be aware of these issues. To cater to this demand, this work proposes the design of an IoT system integrated with machine learning algorithms for classifying block panchayat based on water quality index (WQI) and monitoring the quality of water. This will contribute to improving the water resource management and governance by integrating a machine learning approach for predicting location-specific WQI based on current water quality and seasonal factors for the study area. The district of Alappuzha in the state of Kerala is selected for the study as several areas of this district are below sea level and the water sustainability in this area is affected by agricultural practices, tourism, seawater intrusion in summer, and flooding during the monsoon season. Currently, this study area lacks a continuous monitoring system which can help in effective water resource management. Based on the results of statistical analysis, a platform integrated for continuous real-time monitoring of water sources, and mapping of communities into WQI categories has been proposed. In this work, the historic data from 2010 to 2017 is utilized for deriving the community level classification based on the water quality index.
Stabilization of urinary biogenic amines measured in clinical chemistry laboratories (2020)

Urinary 5-hydroxyindoleacetic acid (5-HIAA), vanillylmandelic (VMA), homovanillic acid (HVA), catecholamines and metanephrines are produced in excess by catecholamine-producing tumors. These biogenic amines are unstable at low or high pH and require hydrochloric acid (HCl) to prevent their degradation. However, HCl addition may result in very low pH causing degradation or deconjugation of several metabolites. This study evaluated the buffering properties of sodium citrate to stabilize all biogenic amines. The metabolite concentrations were measured by LC-MS/MS or by a coulometric assay in 22 urine samples collected native and with HCl or sodium citrate. We studied the effect of pH, time (48 h, four weeks) and storage temperature at 22 °C, 4 °C, and −20 °C. We found that catecholamines degradation was prevented by HCl and citrate and that 5-HIAA was degraded in 5 out of 22 samples collected with HCl. All biogenic amines were efficiently stabilized by citrate for four weeks at 22 °C, except epinephrine (48 h at 4 °C, or four weeks at −20 °C). Sodium citrate did not cause quantification or analytical artefacts concerns. In conclusion, sodium citrate is a non-hazardous alternative to HCl for patients to send unfrozen urine samples to the laboratory which may safely store the sample for four weeks.
Unraveling racial disparities in asthma emergency department visits using electronic healthcare records and machine learning (2020)

Objective Hospital emergency department (ED) visits by asthmatics differ based on race and season. The objectives of this study were to investigate season- and race-specific disparities for asthma risk, and to identify environmental exposure variables associated with ED visits among more than 42,000 individuals of African American (AA) and European American (EA) descent identified through electronic health records (EHRs).Methods We examined data from 42,375 individuals (AAs = 14,491, EAs = 27,884) identified in EHRs. We considered associated demographic (race, age, gender, insurance), clinical (smoking status, ED visits, FEV1%), and environmental exposures data (mold, pollen, and pollutants). Machine learning techniques, including random forest (RF), extreme gradient boosting (XGB), and decision tree (DT) were used to build and identify race- and -season-specific predictive models for asthma ED visits.Results Significant differences in ED visits and FEV1% among AAs and EAs were identified. ED visits by AAs was 32.0% higher than EAs and AAs had 6.4% lower FEV1% value than EAs. XGB model was used to accurately classify asthma patients visiting ED into AAs and EAs. Pollen factor and pollution (PM2.5, PM10) were the key variables for asthma in AAs and EAs, respectively. Age and cigarette smoking increase asthma risk independent of seasons.Conclusions In this study, we observed racial and season-specific disparities between AAs and EAs asthmatics for ED visit and FEV1% severity, suggesting the need to address asthma disparities through key predictors including socio-economic status, particulate matter, and mold.
Insertion of alkenes into rhodium-boron bonds (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInsertion of alkenes into rhodium-boron bondsR. Thomas Baker, Joseph C. Calabrese, Stephen A. Westcott, Paul Nguyen, and Todd B. MarderCite this: J. Am. Chem. Soc. 1993, 115, 10, 4367–4368Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/ja00063a067https://doi.org/10.1021/ja00063a067research-articleACS PublicationsRequest reuse permissionsArticle Views937Altmetric-Citations104LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
A 65-nm SoC Embedded 6T-SRAM Designed for Manufacturability With Read and Write Operation Stabilizing Circuits (2007)

In the sub-100-nm CMOS generation, a large local Vth variability degrades the 6T-SRAM cell stability, so that we have to consider this local variability as well as the global variability to achieve high-yield SRAM products. Therefore, we need to employ some assist circuits to expand the SRAM operating margin. We propose a variability-tolerant 6T-SRAM cell layout and new circuit techniques to improve both the read and the write operating margins in the presence of a large Vth variability. By applying these circuit techniques to a 0.494-mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> SRAM cell with a beta ratio of 1, which is an extremely small cell size, we can achieve a high-yield 8M-SRAM for a wide range of Vth values using a 65-nm low stand-by power (LSTP) CMOS technology
Education materials of electricity and magnetism using MATLAB (2017)

Education materials of electricity and magnetism using MATLAB are presented to improve efficiency of education. Source code becomes simple by using high-layer programming language MATLAB which support matrix operations and graphics routines. Students can concentrate on understanding of physical phenomena. Some parameters can be changed in the source code to see difference of problems.
ChemInform Abstract: Asymmetric Transfer Hydrogenation of C=O and C=N Bonds (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Recycling of platelet phosphorylation and cytoskeletal assembly. (1984)

The shape change and aggregation of washed platelets induced by 10 microM arachidonic acid (AA) can be reversed by 20 ng/ml prostacyclin (PGI2), but these platelets can be reactivated by treatment with 30 microM epinephrine and subsequent addition of 10 microM AA mixture. These events may be modulated by cAMP since 2 mM dibutyryl cAMP also reversed activation without reactivation by epinephrine and AA. We examined protein phosphorylation and formation of cytoskeletal cores resistant to 1% Triton X-100 extraction of these platelets and correlated these processes with aggregation, fibrinogen binding, and changes in ultrastructure. Unactivated platelet cores contained less than 15% of the total actin and no detectable myosin or actin-binding protein. AA-induced cytoskeletal cores, which contained 60-80% of the total actin, myosin, and actin-binding protein as the major components, were disassembled back to unactivated levels by PGI2 and then fully reassembled by epinephrine and AA. Phosphorylation of myosin light chain and a 40,000-dalton protein triggered by AA (two- to fivefold) was reversed to basal levels by PGI2 but was completely restored to peak levels upon addition of the epinephrine and AA mixture. The reversibility of actin-binding protein phosphorylation could not be established clearly because both PGI2 and dibutyryl cAMP caused its phosphorylation independent of activation. With this possible exception, cytoskeletal assembly with associated protein phosphorylation, aggregation, fibrinogen binding, and changes in ultrastructure triggered by activation are readily and concertedly recyclable.
Exudation, Inflammatory Cell Migration and Granulation Tissue Formation in Performed Cavities: A Methodological Study (1973)

The present paper describes a model for analysis of exudation, cell migration and granulation tissue formation in experimentally induced, aseptic inflammation. The method involves the use of subcutaneously implanted, perforated cylinders of Teflon®. Four cylinders were implanted in each of 100 rats under aseptic conditions and were removed at 12 hours, 4, 7, 14 and 21 days. The amount of exudate accumulated in the chamber cavity was measured and the cell content of the exudate analysed. Furthermore the morphology of the tissue surrounding the chamber and proliferating into the chamber cavity was described. Particular attention was paid to the vascular system of this tissue using techniques of microangiography and vascular labelling. The course of the inflammatory process throughout the experimental period is discussed in relation to exudation, inflammatory cell migration and granulation tissue formation.