gebhart/patrepeval huggingface dataset:
A Graphical Workstation Based Part-Task Flight Simulator for Preliminary Rapid Evaluation of Advanced Displays (1992)

&lt;div class="htmlview paragraph"&gt;Advances in avionics and display technology are significantly changing the cockpit environment in current transport aircraft. The MIT Aeronautical Systems Lab (ASL) has developed a part-task flight simulator specifically to study the effects of these new technologies on flight crew situational awareness and performance. The simulator is based on a commercially-available graphics workstation, and can be rapidly reconfigured to meet the varying demands of experimental studies. The simulator has been successfully used to evaluate graphical microburst alerting displays, electronic instrument approach plates, terrain awareness and alerting displays, and ATC routing amendment delivery through digital datalinks.&lt;/div&gt;
Mapping the Role of AcrAB-TolC Efflux Pumps in the Evolution of Antibiotic Resistance Reveals Near-MIC Treatments Facilitate Resistance Acquisition (2020)

ABSTRACT Antibiotic resistance has become a major public health concern as bacteria evolve to evade drugs, leading to recurring infections and a decrease in antibiotic efficacy. Systematic efforts have revealed mechanisms involved in resistance; yet, in many cases, how these specific mechanisms accelerate or slow the evolution of resistance remains unclear. Here, we conducted a systematic study of the impact of the AcrAB-TolC efflux pump on the evolution of antibiotic resistance. We mapped how population growth rate and resistance change over time as a function of both the antibiotic concentration and the parent strain’s genetic background. We compared the wild type strain to a strain overexpressing AcrAB-TolC pumps and a strain lacking functional pumps. In all cases, resistance emerged when cultures were treated with chloramphenicol concentrations near the MIC of their respective parent strain. The genetic background of the parent strain also influenced resistance acquisition. The wild type strain evolved resistance within 24 h through mutations in the acrAB operon and its associated regulators. Meanwhile, the strain overexpressing AcrAB-TolC evolved resistance more slowly than the wild type strain; this strain achieved resistance in part through point mutations in acrB and the acrAB promoter. Surprisingly, the strain without functional AcrAB-TolC efflux pumps still gained resistance, which it achieved through upregulation of redundant efflux pumps. Overall, our results suggest that treatment conditions just above the MIC pose the largest risk for the evolution of resistance and that AcrAB-TolC efflux pumps impact the pathway by which chloramphenicol resistance is achieved. IMPORTANCE Combatting the rise of antibiotic resistance is a significant challenge. Efflux pumps are an important contributor to drug resistance; they exist across many cell types and can export numerous classes of antibiotics. Cells can regulate pump expression to maintain low intracellular drug concentrations. Here, we explored how resistance emerged depending on the antibiotic concentration, as well as the presence of efflux pumps and their regulators. We found that treatments near antibiotic concentrations that inhibit the parent strain’s growth were most likely to promote resistance. While wild type, pump overexpression, and pump knock out strains were all able to evolve resistance, they differed in the absolute level of resistance evolved, the speed at which they achieved resistance, and the genetic pathways involved. These results indicate that specific treatment regimens may be especially problematic for the evolution of resistance and that the strain background can influence how resistance is achieved.
Clinical and radiological long term results of the biopolymer graft (BOP) in anterior cervical surgery (2001)

info:eu-repo/semantics/nonPublished
P-HRTF: Efficient personalized HRTF computation for high-fidelity spatial sound (2014)

Accurate rendering of 3D spatial audio for interactive virtual auditory displays requires the use of personalized head-related transfer functions (HRTFs). We present a new approach to compute personalized HRTFs for any individual using a method that combines state-of-the-art image-based 3D modeling with an efficient numerical simulation pipeline. Our 3D modeling framework enables capture of the listener's head and torso using consumer-grade digital cameras to estimate a high-resolution non-parametric surface representation of the head, including the extended vicinity of the listener's ear. We leverage sparse structure from motion and dense surface reconstruction techniques to generate a 3D mesh. This mesh is used as input to a numeric sound propagation solver, which uses acoustic reciprocity and Kirchhoff surface integral representation to efficiently compute an individual's personalized HRTF. The overall computation takes tens of minutes on multi-core desktop machine. We have used our approach to compute the personalized HRTFs of few individuals, and we present our preliminary evaluation here. To the best of our knowledge, this is the first commodity technique that can be used to compute personalized HRTFs in a lab or home setting.
Simulative Analysis of Access Selection Algorithms for Multi-Access Networks (2006)

It is expected that future wireless systems will consist of several distinct radio access technologies (including WCDMA/HSDPA, GSM/EDGE/GPRS, WLAN and others) forming a multi-access system that offers advanced voice and multimedia services. Previous works have shown that the combined capacity region of such systems depend on the service allocation policy that assigns user sessions to the available subsystems. The currently available service allocation policies typically operate off-line implying that the actual service mix is assumed to be known prior to the service allocation taking place. In this paper we consider the on-line problem according to which sessions arrive one after the other and no assumptions on the service mix can be made. We adopt four on-line bin-packing algorithms to the multi-access environment and study their performance by means of simulation in terms of the class-wise blocking probability and throughput. We find that the algorithm termed Less Voice provides the best performance in terms of the blocking probabilities and imposes the least slow down for elastic sessions
Research article The 9-lipoxygenase GhLOX1 gene is associated with the hypersensitive reaction of cotton Gossypium hirsutum to Xanthomonas campestris pv malvacearum (2007)

Hypersensitive reaction (HR) cell death of cotton to the incompatible race 18 from Xanthomonas campestris pathovar malvacearum (Xcm )i s associated with 9S-lipoxygenase activity (LOX) responsible for lipid peroxidation. Here, we report the cloning of cotton (Gossypium hirsutum L.) LOX gene (GhLOX1) and the sequencing of its promoter. GhLOX1 was found to be highly expressed during Xcm induced HR. Sequence analysis showed that GhLOX1 is a putative 9-LOX, and GhLOX1 promoter contains SA and JA responsive elements. Investigation on LOX signalisation on cotyledons infiltrated with salicylic acid (SA), or incubated with methyl-jasmonate (MeJA) revealed that both treatments induced LOX activity and GhLOX1 gene expression. HR-like symptoms were observed when LOX substrates were then injected in treated (MeJA and SA) cotyledons or when Xcm compatible race 20 was inoculated on MeJA treated cotyledons. Together these results support the fact that GhLOX1 encodes a 9 LOX whose activity would be involved in cell death during cotton HR. 2007 Elsevier Masson SAS. All rights reserved.
Fusariose du maïs: évaluation de la sensibilité des variétés cultivées en Suisse (2016)

MultipleLa fusariose du mais reduit la quantite et la qualite de la recolte de grain. Les mycotoxines produites par les pathogenes fongiques impliques menacent la sante des animaux affourages. Un des facteurs influencant la severite de la maladie et la teneur en toxines – et donc un levier de lutte potentiel – est le niveau de resistance de la variete cultivee. Les travaux presentes ici visaient a etablir une methodologie permettant d’evaluer cette resistance et de l’utiliser ensuite pour tester les hybrides de maisgrain cultives en Suisse. Une methode procedant par inoculation artificielle des epis lors de la floraison pendant au minimum trois ans d’essai a permis d’identifier des varietes tres sensibles, peu sensibles et intermediaires. Ce classement est un outil que les maisiculteurs peuvent utiliser lors du choix varietal pour gerer le risque de fusariose et de contamination en mycotoxines EnglishGibberella and fusarium ear rot of maize reduce grain yield qualitatively and quantitatively. Mycotoxins produced by the fungal pathogens that are responsible of these two diseases are a health threat for the animals fed with contaminated maize. One factor affecting disease severity and mycotoxin content, and therefore a potential management tool, is the susceptibility of the cultivated variety. This study aimed at establishing a methodology to evaluate this resistance level and then use is to test grain maize hybrids grown in Switzerland. A method using artificial inoculation of the ears at female flowering during at least three experimental years allowed to identify very susceptible, less susceptible and intermediate varieties. This ranking is a tool that maize growers may use while choosing a variety to manage the risk of Gibberella ear rot and of mycotoxin contamination. italianoLa fusariosi del mais fa diminuire la quantita e la qualita del raccolto di semi. Le micotossine prodotte dai patogeni fungini coinvolti minacciano la salute degli animal foraggiati. Uno dei fattori che influenzano la gravita della malattia e il tenore di tossine, e di conseguenza un potenziale strumento di lotta, e il livello di resistenza della varieta coltivata. I lavori qui presentati mirano a sviluppare una metodologia che permetta di valutare questa resistenza e di sfruttarla in seguito per testare gli ibridi di mais da granella coltivati in Svizzera. Un metodo, messo in atto tramite inoculazione artificiale delle spighe al momento della fioritura per almeno tre anni di sperimentazione, ha permesso di identificare delle varieta molto sensibili, poco sensibili e intermedie. Tale classificazione si rivela uno strumento utile per i coltivatori di mais al momento di scegliere la varieta per tenere sotto controllo il rischio di fusariosi e di contaminazione da micotossine.
You're getting warmer! (2003)

This paper describes the results of a Wizard of Oz study of people's search behavior using BuddySystem, a proximity-sensing system designed to help end-users locate people, places, and things. BuddySystem uses distance estimation based on signal strength alone, since direction is difficult to obtain in ad-hoc radio-based systems. Overall findings indicate that the BuddySystem changed people's search behavior to reduce walking area, but may increase search times if the system demands too much of the user's attention, suggesting that reducing distractions and adjusting search strategies could improve search effectiveness of proximity-based tracking systems in physical spaces.
Towards an innovative spectral-splitting hybrid PV-T micro-concentrator (2012)

A hybrid concentrator PV-Thermal (CPV-T) system for delivery of electricity and 150°C hot fluid in a structure suitable for roof-top installation on domestic, commercial, and industrial buildings is being developed by ANU in collaboration with the University of New South Wales, CSIRO, and industry partners. A first design based on beam-splitting utilising liquid-absorption filters is being analysed, with a study of the most suitable candidate fluids. An initial selection of four liquids was conducted; with the liquids subjected to accelerated tests to analyse their long-term performance and possible optical and chemical degradation. Some of the fluids showed optical changes after high temperature test and UV exposure, leading to slight yellowing.
HVDC flashover performance of fibreglass reinforced (FRP) hot sticks considering space charges (2017)

In high voltage direct current (HVDC) electric power systems, live-line maintenance methods are being used to enhance their reliability and avoid costly outages. Live-line working standards presently do not consider the impact of charge on the surface of live line tools. Electric field stresses produced due to surface charging of polymeric materials under HVAC and HVDC operating conditions are different in distribution and magnitude. Recently, more attention has been given to the study of surface charging characteristics of polymeric materials and its impact on DC flashover voltage. In this work, two sources for generating space charges on a sample of FRP tool are used; a corona ring of needles and pre-stressing from one electrode with the other electrode grounded. Before flashover testing, the samples are firstly charged, and then the applied DC voltage is ramped until flashover occurs. The DC flashover voltage and leakage current are monitored at every test to identify the effect of surface charges. The effects on the flashover voltage due to the presence of surface charge are investigated by applying both polarities of voltage when charges pre-existed on the surface. This paper aims at providing an understanding of DC flashover characteristics of FRP hot-sticks due to surface charging by direct contact and/or corona discharge of nearby energized parts.
Bile-Tagged 3D Magnetic Resonance Colonography After Exclusive Intravenous Administration of Gadobenate Dimeglumine, a Contrast Agent with Partial Hepatobiliary Excretion (2001)

We report for the first time the feasibility of exclusively bile-tagged MR colonography with the use of only an intravenous MR contrast that exhibits partial hepatobiliary excretion. This new diagnostic procedure will enable not only morphological assessment of the colon but also functional and pathophysiological studies on the transport kinetics of bile and stool without any preparation of the patient.
Cardea: Cloud based employee health and wellness integrated wellness application with a wearable device and the HCM data store (2014)

This paper discusses an experimental integrated wellness application that syncs with a wearable device and with a human capital management database to provide a full picture of health and wellness. Wellness is measured at the individual level as well as at the group level. This application uses domain specific algorithms, which are based on scientific research and analysis of biometric data. We investigate the effect of this application on user behavior and wellness habits. We also look for correlations between companies' policies, culture, management practices, and wellness.
Novel architectures for P2P applications (2003)

We propose a new approach for constructing P2P networks based on a dynamic decomposition of a continuous space into cells corresponding to processors. We demonstrate the power of these design rules by suggesting two new architectures, one for DHT (Distributed Hash Table) and the other for dynamic expander networks. The DHT network, which we call Distance Halving allows logarithmic routing and load, while preserving constant degrees. It offers an optimal tradeoff between the degree and the dilation in the sense that degree d guarantees a dilation of O(log d n). Another advantage over previous constructions is its relative simplicity. A major new contribution of this construction is a dynamic caching technique that maintains low load and storage even under the occurrence of hot spots. Our second construction builds a network that is guaranteed to be an expander. The resulting topologies are simple to maintain and implement. Their simplicity makes it easy to modify and add protocols. A small variation yields a DHT which is robust against random faults. Finally we show that, using our approach, it is possible to construct any family of constant degree graphs in a dynamic environment, though with worst parameters. Therefore we expect that more distributed data structures could be designed and implemented in a dynamic environment.
Strong Inhibition of Cholera Toxin by Multivalent GM1 Derivatives (2007)

Sticky fingers. The optimal ligand for the cholera toxin (CT), GM1-oligosaccharide (GM1os), was linked to dendritic structures that contained long spacer arms by using highly efficient “click” chemistry coupling. In the inhibition studies very large multivalency effects were observed; the best structure was an unprecedented 380 000-fold more potent ligand for the toxin than a monovalent GM1os derivative.
Effects of SrTiO3 substrate orientations on crystal and domain structures and electric properties of NaNbO3–SrZrO3 films (2018)

0.92NaNbO3–0.08SrZrO3 films were grown on SrRuO3/(001) and (110) SrTiO3 substrates by pulsed laser deposition. SEM observation showed that the films on the SrRuO3-coated (001) and (110) SrTiO3 substrates had flat and stripe like surface morphologies and thicknesses of 0.4 and 0.7 µm, respectively. X-ray reciprocal space mapping indicated that both films had antiferroelectric domains. The dielectric constant of 180 and the tan δ of 0.02 for the film grown on the SrRuO3/(001) SrTiO3 substrate and the dielectric constant of 300 and the tan δ of 0.04 for the film grown on the SrRuO3/(110) SrTiO3 substrate were observed. Polarization–electric field (P–E) responses were ferroelectric and antiferroelectric for the films grown on the SrRuO3/(001) and (110) SrTiO3 substrates, respectively. The differences in the dielectric properties and P–E responses of the films were discussed with emphasis on their domain configurations.
The {111}‐Modulated Domains in Tetragonal BaTiO 3 (2006)

Barium titanate (BaTiO 3 ) base‐metal electrode multilayer ceramic capacitors of an X7R‐formulation, sintered at 1200°C under low oxygen partial pressures (of p O 2 ≈10 −9 and 10 −11 atm, respectively), followed by annealing at 1000°C in an atmosphere containing a higher oxygen partial pressure (of p O 2 ≈10 −5 –10 −6 atm), have been analyzed for crystalline phases using X‐ray diffractometry, for microstructure using transmission electron microscopy, and for microchemistry using energy‐dispersive X‐ray spectroscopy and electron energy loss spectroscopy. The classical core–shell structure characterized by a core consisting of tetragonal ferroelectric {011) domains and featureless shell (designated type I) was observed only in sample A sintered in p O 2 ≈10 −9 atm. For sample B sintered in p O 2 ≈10 −11 atm, the core–shell structure is predominantly type II, consisting of a featureless shell similar to type I, but a core of modulated domains. The core of type II contained incommensurately modulated {111} superlattice domains along 〈111〉. The superlattice can be described by a displacive modulation with incommensurate wave vectors k 1 =0.58a * , k 2 =0.58b * , and k 3 =0.58c * . It is due to the ordering of defect associates , generated extrinsically from sintering in low p O 2 . Shell thickness was determined by the lattice diffusion of Ca 2+ solute cations into BaTiO 3 grains during sintering. The core–shell interface became less distinguishable in type II because defect associates , unlike those in type I, were not completely eliminated by re‐oxidizing in p O 2 ≈10 −5 –10 −6 atm, but became ordered along 〈111〉 and gave rise to structural modulation.
La mort dans l'âme (2007)

En etudiant le cas clinique d’un jeune Philippin presentant les symptomes d’une melancolie, l’auteur s’interroge sur les elements culturels qui lui donnent forme. La fonction de ceux-ci ne serait-elle pas d’offrir au malade une premiere tentative d’auto-guerison, tout en adressant un appel a l’aide intelligible a son groupe social ?
Biochemical and Genetic Analyses of Ferulic Acid Catabolism in Pseudomonas sp. Strain HR199 (1999)

The gene loci fcs, encoding feruloyl coenzyme A (feruloyl-CoA) synthetase, ech, encoding enoyl-CoA hydratase/aldolase, and aat, encoding beta-ketothiolase, which are involved in the catabolism of ferulic acid and eugenol in Pseudomonas sp. strain HR199 (DSM7063), were localized on a DNA region covered by two EcoRI fragments (E230 and E94), which were recently cloned from a Pseudomonas sp. strain HR199 genomic library in the cosmid pVK100. The nucleotide sequences of parts of fragments E230 and E94 were determined, revealing the arrangement of the aforementioned genes. To confirm the function of the structural genes fcs and ech, they were cloned and expressed in Escherichia coli. Recombinant strains harboring both genes were able to transform ferulic acid to vanillin. The feruloyl-CoA synthetase and enoyl-CoA hydratase/aldolase activities of the fcs and ech gene products, respectively, were confirmed by photometric assays and by high-pressure liquid chromatography analysis. To prove the essential involvement of the fcs, ech, and aat genes in the catabolism of ferulic acid and eugenol in Pseudomonas sp. strain HR199, these genes were inactivated separately by the insertion of omega elements. The corresponding mutants Pseudomonas sp. strain HRfcsOmegaGm and Pseudomonas sp. strain HRechOmegaKm were not able to grow on ferulic acid or on eugenol, whereas the mutant Pseudomonas sp. strain HRaatOmegaKm exhibited a ferulic acid- and eugenol-positive phenotype like the wild type. In conclusion, the degradation pathway of eugenol via ferulic acid and the necessity of the activation of ferulic acid to the corresponding CoA ester was confirmed. The aat gene product was shown not to be involved in this catabolism, thus excluding a beta-oxidation analogous degradation pathway for ferulic acid. Moreover, the function of the ech gene product as an enoyl-CoA hydratase/aldolase suggests that ferulic acid degradation in Pseudomonas sp. strain HR199 proceeds via a similar pathway to that recently described for Pseudomonas fluorescens AN103.
Lanthanide ions as sensitive probes in intermolecular energy transfer and organic photochemistry. Annual progress report (1974)

Research progress is reported in the following areas: (1) the spectroscopic properties and behavior of positively charged organic sensitizers, for lanthanide ion energy acceptors, (2) distant interaction between nonconjugated electronic systems in rigid model molecules, (3) generation of stable paramagnetic species from selected organic heterocyclic energy donors, (4) preliminary experiments of hydroxycarbonium ion-europium energy transfer, and (5) photochemical reactions of donors of excitation energy competing effectively with transfer of energy to lanthanide acceptors. Titles of preprints and manuscripts attached to the report are: Electronic Absorption and Emission of Aromatic Hydroxycarbonium Ions,'' On the Configuration of Dienestrol,'' Through-Space Interaction Between Nonconjugated Napthalene and Phenanthrene in a Rigid Molecule,'' and Formation of LongLived Free Radicals from Acylpyridinium Salts with Alkali.'' (DHM)