gebhart/patrepeval huggingface dataset:
Sodium determination by nuclear magnetic resonance spectrometry (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSodium determination by nuclear magnetic resonance spectrometryAnthony L. Van Geet and Gareth J. TemplemanCite this: Anal. Chem. 1975, 47, 8, 1448–1449Publication Date (Print):July 1, 1975Publication History Published online1 May 2002Published inissue 1 July 1975https://pubs.acs.org/doi/10.1021/ac60358a058https://doi.org/10.1021/ac60358a058research-articleACS PublicationsRequest reuse permissionsArticle Views663Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis (2010)

We suggest that CA IX should be considered a potential prognostic and therapeutic target in MBs and PNETs.
The effect of modifications to clinical trial activities implemented during the COVID-19 pandemic on willingness to participate in clinical trials: The TBCRC 057 survey. (2022)

97 Background: In order to maintain safety, clinical trial activities have been modified during the COVID-19 pandemic. As part of the TBCRC 057 survey, we assessed how pandemic-related modifications to trial activities affect breast cancer patients’ willingness to participate in clinical trials. Methods: US residents with breast cancer were eligible to complete the online survey 8/6/21 – 9/30/21. Respondents rated whether each of 11 modifications to clinical trial activities would affect their decision to participate in a trial during or after the pandemic. Items evaluated modifications that involved changing the location of trial activities to closer to home, switching trial activities to telemedicine and making the trial schedule more flexible and convenient. Response options were “much less likely to participate”, “somewhat less likely to participate”, “would not affect my decision whether or not to participate”, “somewhat more likely to participate” and “much more likely to participate”. Current trial participants were asked to consider how modifications would affect their decision to participate in another trial. Results are reported descriptively. Results: Among 385 respondents, median age was 52 (range 25-85), 88.6% were non-Hispanic White, 52.5% had metastatic disease, 93% were receiving active treatment, 48.6% received care at an academic center and 9.6% were current trial participants. Changing location of trial activities was viewed favorably, with 70.2%, 64.6% and 54.1% of respondents indicating they would be much or somewhat more likely to participate if they could complete trial blood tests, x-ray tests or doctor visits closer to home, respectively. Similarly, the option to complete trial activities electronically was viewed favorably, with 59.6%, 58.6% and 60.9% of respondents indicating they would be much or somewhat more likely to participate if they could complete trial doctor visits, consent and questionnaires via telemedicine, respectively. With regard to modifications to make the trial schedule more flexible and convenient, respondent feedback was also favorable. 71.4%, 67.7% and 82.4% of respondents indicated that requiring study site visits no more than once per 3 weeks, widening windows for trial activities and offering home delivery of oral study medications, respectively, would make them much or somewhat more likely to participate. Finally, 30.4% and 51.7% indicated that the flexibility to opt-out of research-only blood tests and biopsies, respectively, would make them much or somewhat more likely to participate. Conclusions: Patients view modifications to trial activities implemented during the pandemic favorably. Trials should be flexible and the option to conduct study activities close to home or electronically when possible should be maintained during the pandemic and beyond.
Cardiac Resynchronization Therapy Device Implantation in Patients with Therapeutic International Normalized Ratios (2010)

Our findings suggest that implantation of CRT-Ds without interruption of warfarin therapy in patients at high risk of thromboembolic events is a safe alternative to routine bridging therapy. This strategy is associated with reduced risk of pocket hematomas and shorter length of hospital stay. (PACE 2010; 400-406).
Bispecific Antibody Armed Metabolically Enhanced Headless CAR T Cells (2021)

Adoptive T cell therapies for solid tumors is challenging. We generated metabolically enhanced co-activated-T cells by transducing intracellular co-stimulatory (41BB, ICOS or ICOS-27) and CD3ζ T cell receptor signaling domains followed by arming with bispecific antibodies (BiAbs) to produce armed "Headless CAR T cells" (hCART). Various hCART armed with BiAb directed at CD3ϵ and various tumor associated antigens were tested for: 1) specific cytotoxicity against solid tumors targets; 2) repeated and dual sequential cytotoxicity; 3) survival and cytotoxicity under <i>in vitro</i> hypoxic condition; and 4) cytokine secretion. The 41BBζ transduced hCART (hCART<sub>41BBζ</sub>) armed with HER2 BiAb (HER2 hCART<sub>41BBζ</sub>) or armed with EGFR BiAb (EGFR hCART<sub>41BBζ</sub>) killed multiple tumor lines significantly better than control T cells and secreted Th<sub>1</sub> cytokines/chemokines upon tumor engagement at effector to target ratio (E:T) of 2:1 or 1:1. HER2 hCART serially killed tumor targets up to 14 days. Sequential targeting of EGFR or HER2 positive tumors with HER2 hCART<sub>41BBζ</sub> followed by EGFR hCART<sub>41BBζ</sub> showed significantly increased cytotoxicity compared single antigen targeting and continue to kill under <i>in vitro</i> hypoxic conditions. In summary, metabolically enhanced headless CAR T cells are effective serial killers of tumor targets, secrete cytokines and chemokines, and continue to kill under <i>in vitro</i> hypoxic condition.
Poly(3,4-ethylenedioxythiophene) (PEDOT)-Coated Silica Spheres:  Electrochemical Modulation of the Optical Properties of a Hydrogel-Stabilized Core−Shell Particle Suspension (2006)

In situ electrochemical methods involving both oxidative and reductive mediators were employed to modify the oxidation state (doping level) of PEDOT polymers in colloidal PEDOT-coated silica core−shell particles that were prepared as a dispersion encapsulated in a hydrogel matrix. The hydrogel-stabilized PEDOT particle suspensions were prepared as thin films (several hundred micrometers thick) on an ITO electrode surface and were equilibrated with an aqueous electrolyte containing a cocktail of redox mediators prior to mounting in a transmission-mode spectroelectrochemical cell. The modifications of the redox states of the PEDOT coating induced a change in the absorbance characteristics of the hydrogel films. The coated particles exhibited a maximum absorption peak centered at 800 nm in their doped (oxidized) state that could be significantly reduced through the electrochemical de-doping (reduction) of the PEDOT-coating on the particles.
Measurement of properties of perfluorocarbon/SF/sub 6/ mixtures relevant to applications (1980)

It has been found that the addition of 2-C/sub 4/F/sub 8/ to pure SF/sub 6/ or SF/sub 6//N/sub 2/ mixtures has a pronounced effect on the non-uniform field breakdown. This effect can be attributed to increased positive and negative ion production which leads to enhanced space charge effects. If this interpretation is correct, addition of 2-C/sub 4/F/sub 8/ or other perfluorocarbons with large electron attachment rates and low ionization onsets can be used in SF/sub 6/ and SF/sub 6//N/sub 2/ mixtures to modify the space charge behavior of the gas. The formation of carbon as a breakdown product in perfluorocarbon containing dielectric gas mixtures can be suppressed or eliminated by introduction of components such as SF/sub 6/ (or presumably other oxidizer(s)) to react with the discharge products. Mixtures can be formulated with greatly improved dielectric strengths over that of SF/sub 6/ without the disadvantage of carbon formation upon sparking. These investigations of the non-uniform field breakdown and carbon inhibition under sparking of 2-C/sub 4/F/sub 8/ mixtures show that mixtures with superior dielectric strengths (e.g., 20% 2-C/sub 4/F/sub 8//80% SF/sub 6/) under non-uniform field conditions and little or no carbon formation upon sparking are now available. Optimization of these properties ismore » being pursued.« less
Sub-Nanometer Precision using Bayesian Grouping of Localizations (2019)

Abstract Single-molecule localization microscopy super-resolution methods such as DNA-PAINT and (d)STORM can generate multiple observed localizations over the time course of data acquisition from each dye or binding site that are not a priori assigned to those specific dyes or binding sites. We describe a Bayesian method of grouping and combining localizations from multiple blinking/binding events that can improve localization precision to better than one nanometer. The known statistical distribution of the number of binding/blinking events per dye/docking strand along with the precision of each localization event are used to estimate the true number and location of emitters in closely-spaced clusters.
Design method for an anthropomorphic hand able to gesture and grasp (2015)

This paper presents a numerical method to conceive and design the kinematic model of an anthropomorphic robotic hand used for gesturing and grasping. In literature, there are few numerical methods for the finger placement of human-inspired robotic hands. In particular, there are no numerical methods, for the thumb placement, that aim to improve the hand dexterity and grasping capabilities by keeping the hand design close to the human one. While existing models are usually the result of successive parameter adjustments, the proposed method determines the fingers placements by mean of empirical tests. Moreover, a surgery test and the workspace analysis of the whole hand are used to find the best thumb position and orientation according to the hand kinematics and structure. The result is validated through simulation where it is checked that the hand looks well balanced and that it meets our constraints and needs. The presented method provides a numerical tool which allows the easy computation of finger and thumb geometries and base placements for a human-like dexterous robotic hand.
CCDC 1505864: Experimental Crystal Structure Determination (2017)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
ChemInform Abstract: ELECTROCHEMICAL PATTERNING OF TIN OXIDE FILMS (1977)

Abstract Die Untersuchungen werden an P‐dotierten Filmen durchgeführt, die durch gleichzeitige Oxidation von Me 4 Sn und PH 3 auf Si‐ und Ga‐arsenid abgeschieden und unmittelbar darauf mit einer durch die Oxidation von Silan erzeugten SiO 2 ‐Schicht überzogen werden.
ChemInform Abstract: High‐Spin Molecules: A Novel Cyano‐Bridged Mn9IIMo6V Molecular Cluster with a S = 51/2 Ground State and Ferromagnetic Intercluster Ordering at Low Temperatures. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Creation of Nanorobots: Both State-of-the-Science and State-of-the-Art (2017)

Over the last decade, remarkable achievements in nanofabrication technology has led to the development of hybrid intelligent systems including the nanomechanical devices powered by the chemical energy sources or biomolecular motors. In this context, nanorobotics has emerged as a highly-advanced technology for designing the fully functional smart devices or robots at nano scale. Development of these highly-controlled and functional nanostructures for sensing, information processing, signaling, and actuation may provide remarkable breakthroughs in medicine such as the improved imaging or targeted therapeutic interventions. Besides the detection and destroying the toxic materials and ecosystem restoration, the stimuli-responsive nanorobots may be used for the diagnosis or treatment of cardiac disorders, traumatic injuries, diabetes, and bacterial or viral infections. These molecular tools with nanoscale resolution facilitates early diagnosis in cancer and precise localization of anticancer agents leading to the minimal side effects. Nanorobots may easily traverse the human body and repair the cells or assist an improper functioning organ. These tiny devices integrated with wireless locomotion, external or internal power supply, artificial intelligence, and smart sensors may also be used for targeted delivery of genes or drugs into the single cells or tissues, tele-operation, or patient monitoring. Indeed, development of the medical nanorobots with a wide range of capabilities is a proof of concept and art in modern science and a breakthrough in nanotechnology which has been highlighted in the present manuscript.
Dynamics of a Closed-Loop Thermosyphon Incorporating Thermal Storage (2008)

The coupling between a natural-convection thermosyphon loop and a thermal storage device is analyzed numerically for a charging process in which energy is added to the system at a fixed rate. Since energy accumulates in the storage component, the driving buoyant force is continually altered and the behavior is inherently transient. The undesirable consequence is a less than uniform charge of the storage volume. Relevant dimensionless parameters are identified which enable improvement in the shape of the charge profile. The results indicate that a more uniform charge profile is obtained by targeting the frictional losses to a flow regime most strongly proportional to flow rate and by decreasing the relative vertical height over which heat input occurs.
Hyperspectral scanning laser optical tomography (2018)

In order to study physical relationships within tissue volumes or even organism-level systems, the spatial distribution of multiple fluorescent markers needs to be resolved efficiently in three dimensions. Here, rather than acquiring discrete spectral images sequentially using multiple emission filters, a hyperspectral scanning laser optical tomography system is developed to obtain hyperspectral volumetric data sets with 2-nm spectral resolution of optically transparent mesoscopic (millimeter-centimeter) specimens. This is achieved by acquiring a series of point-scanning hyperspectral extended depth of field images at different angles and subsequently tomographically reconstructing the 3D intensity distribution for each wavelength. This technique is demonstrated to provide robust measurements via the comparison of spectral and intensity profiles of fluorescent bead phantoms. Due to its enhanced spectral resolving ability, this technique is also demonstrated to resolve largely overlapping fluorophores, as demonstrated by the 3D fluorescence hyperspectral reconstruction of a dual-labeled mouse thymus gland sample and the ability to distinguish tumorous and normal tissues of an unlabeled mouse intestine sample.
[Reversibility of left ventricular functional damage after valve replacement in patients with chronic aortic valve insufficiency]. (1989)

The authors study retrospectively some preoperative echocardiographic findings and their importance as predictors of reversible myocardial dysfunction. The functional status of 57 survivors after isolated aortic valve replacement was evaluated with exercise testing and on this ground the patients, were divided into three groups: A (28 pts) greater than 60%; C (10 pts) less than 40%; B (19 pts) from 40% to 60%. The authors conclude that the postoperative improvement in functional status is strictly correlated with some preoperative echocardiographic indexes (end-diastolic dimension, end-systolic dimension, shortening fraction, mean end-systolic radius/thickness ratio, end-systolic wall stress, myocardial mass, ejection fraction) with are also predictive of operative mortality. The authors consider the principal values of beginning left ventricular impairment: a) end-systolic dimension greater than or equal to 5.5 cm; b) shortening fraction less than 27%; c) mean end-systolic radius/thickness ratio greater than 2.5; d) end-systolic wall stress greater than 240 mmHg.
The lytic enzyme in bacteriophage ÏM1-induced lysates ofMethanobacterium thermoautotrophicumMarburg (1992)

The lytic enzyme from bacteriophage ψM1-induced lysates of Methanobacterium thermoautotrophicum was purified approx. 80-fold to near electrophoretic homogeneity. It was a 31-kDa monomeric, oxygen-sensitive pseudomurein endopeptidase hydrolysing the ?-Ala-Lys bond of pseudomurein. Pseudomurein endopeptidase-specific polyclonal antibodies reacted with a 31-kDa protein in crude extracts of non-infected host cells. This cross-reacting protein was purified. It did not exhibit lytic activity but its N-terminus was identical with the N-terminus of pseudomurein endopeptidase. The 31-kDa protein thus probably represents a pseudomurein endopeptidase whose autolytic activity is under control in non-infected, but deregulated in phage ψM1-infected cells. Its preferential location in the cell-wall area was demonstrated by immuno-electron microscopy and argued for a role of pseudomurein endopeptidase in the expansion of the cell wall during growth.
Physical Mechanisms of Nonlinear Optical Activity in Crystals (1984)

Possible mechanisms of nonlinear optical activity (NLOA) in crystals connected with electronic nonlinearities are considered in this work. Relations are obtained that describe nonlinear changes in the structure of light polarization in a medium having weak, arbitrary nonlinearity. It is shown that in media with third-order nonlinearity, NLOA may be linked either with the distribution of nonlinearity in the medium or with the anisotropy of nonlinear absorption-so-called absorptive and dispersive NLOA.
Is tamoxifen prevention in younger women underutilized? Analysis of competing causes of mortality (2006)

647 Background: Our past work on Tamoxifen impacting overall mortality outcome among survivors of the 1 st breast cancer (JCO, 1998, 16:2018–24) introduced methodology permitting analyses of competing cause mortality, adjustable as new data emerge. This analysis estimates Tamoxifen impact on four conditions among BrCa survivors known to be affected by Tamoxifen, i.e. contralateral breast cancer; uterine cancer, cardiovascular (CVS) mortality, and thromboembolism (TE). Updated RR rates of Tamoxifen impacting the four conditions were obtained from recent literature (Lancet, 2005, 365:1687–1717; JNCI,2005, 97:1652–62; 97:1609–10). Methods: The effect of Tamoxifen was calculated by applying Relative Risk Rates (RR) to the respective underlying Canadian age-specific mortality figures, separately for each condition. The final mortality impact was the “net mortality”, defined as differences of deaths, from each condition, between 1,000 Tamoxifen users vs 1,000 non-users (Dif N/1,000), expressed for ages &lt;50 and &gt;50. (i.e sum of avoidances [-] vs hazards[+]) Results: see Table below. Conclusion: Our results show a favorable Tamoxifen impact on overall mortality, particularly evident for women age &lt;50, in whom the breast cancer mortality reduction significantly outweighs the hazards. These data are applicable to Tamoxifen prevention in population-women who are at high risk for BrCa. Their outcome profiles affected by Tamoxifen mirror those of the survivors of the 1 st BrCa. While for women &gt;50, other chemoprevention alternatives exist (i.e. trials of Aromatase Inhibitors), for younger women no chemoprevention trials are presently in existence. Our data indicate that in those, routine use of Tamoxifen may save substantial numbers of lives. [Table: see text] No significant financial relationships to disclose.
Los procedimientos de validación de los documentos públicos en el derecho de extranjería: especial referencia a la apostilla electrónica (2012)

En los procedimientos de autorizaciones de extranjeria se solicita la aportacion de documentos publicos extranjeros, respecto a los cuales se requiere su autenticidad extrinseca. De nuevo, la legislacion de extranjeria omite toda referencia al requisito de la legalizacion de los documentos publicos extranjeros para que surtan efectos ante las autoridades espanolas. El proceso de legalizacion puede eximirse totalmente cuando un Tratado Internacional asi lo prevea, o bien puede substituirse por el tramite de la apostilla en virtud del Convenio de La Haya de 1961 y, recientemente, a traves de la apostilla electronica, de la cual Espana es pionera. Por su parte, la Union Europea
ha iniciado los estudios para legislar, en aras del reconocimiento mutuo, normativa que permita la libre circulacion de documentos publicos en el seno de la Union facilitando los tramites administrativos a los ciudadanos europeos.
Automatic design with dependence graphs (1980)

A design automation system for the design of digital systems from a high-level algorithmic description is proposed. The definition of the data-dependence graph and techniques for performing transformations that lead to optimization of hardware are described. The system can be used on several levels of design with the VLSI layout level given particular emphasis.
Real-time observation of disintegration processes within argon clusters ionized by a hard-x-ray pulse of moderate fluence (2020)

We present a time-resolved study of disintegration within atomic clusters ionized by a hard-x-ray pulse of moderate fluence. It was performed with electron and ion spectroscopy, and complemented by theoretical simulations. The expanding clusters were probed with a near-infrared (NIR) laser pulse over a range of pump-probe delays from \ensuremath{-}4 to 10 ps. In addition to an increasing number of singly charged atomic ions, originating from the ionization of Rydberg atoms formed through electron-ion recombination, we observe a decrease of oligomer yields. The latter is due to the interaction of oligomers with the NIR probe pulse, leading to their dissociation. At time delays between \ensuremath{-}1 and 2 ps, efficient absorption of the NIR laser energy occurs, even though the NIR intensity is too low to trigger tuneling ionization of Ar atoms. Our observations are similar to earlier observations of the fragmentation behavior of clusters excited by soft-x-ray pulses. This indicates that the relaxation dynamics of x-ray-excited nano-objects are universal over a wide range of excitation photon energies.