gebhart/patrepeval huggingface dataset:
Innate Immune Response and Inflammation: Roles in Pathogenesis and Protection (Rickettsiaceae) (2014)

Although spotted fever group rickettsiae (SFGR) and typhus group rickettsiae (TGR) represent two major antigenically defined and historically well-known subdivisions of pathogenic Rickettsia species, recent in-depth characterization by neighbor-joining phylodendrogramic analysis has distributed rickettsiae into ancestral, spotted fever, typhus, and transitional subgroups. Importantly, well-established and widely accepted in vivo models of infection closely mimicking the pathogenesis of Rocky Mountain spotted fever (RMSF) and epidemic typhus in humans employ infection of susceptible mouse strains with Rickettsia conorii and R. typhi, respectively. The endothelial cell responses to R. prowazekii and signaling mechanisms that determine the interplay between the host and the unique rickettsial pathogen, which is capable of escaping immune surveillance to cause recrudescent infections, remain critically important but neglected areas of scientific inquiry. Thus, one of the major critical gaps in the understanding of rickettsial pathogenesis is the definition of the biological basis of rickettsial affinity and consequent interactions with vascular endothelium. R. rickettsii infection induces a biphasic pattern of NF-KB activation in cultured human endothelial cells that is characterized by an early transient activation phase and a late sustained phase. There is increasing recognition that apoptosis, a tightly regulated process of altruistic suicide, plays a central role in complex interactions between an invading pathogen and host cell defense. First recognized for their ability to impede viral replication, interferons (IFNs) play a critical role in determining host survival in response to viral infection. During bacterial infections, IFN signaling defends the host by integrating early innate immune responses with later events.
Environmental and steric effects on electronic and vibrational properties of pyridinium phenoxide derivatives (2004)

Our present understanding of the dependence of non linear optical (NLO) properties of charge transfer compounds on their dielectric environment is generally summarized as a set of universal response functions versus the ground state ionicity. Experimentally, these behaviors are recovered by piece-wise assembling measurements performed in solvents of increasing polarities on series of chromophores with varying acceptor and donor groups and/or conjugation paths. In this work, we will take advantage of the recent success in synthesizing pyridinium phenoxides with or without tert-butyl oxygen protection groups as well as with or without steric methyl groups to modify the twisting of the central diaryl bond. Thus, we are in a position to sweep over a wide range of zwitterionic character with essentially the same chromophore. This opens up a great opportunity to investigate the relationships between geometrical structure and NLO properties, to examine the validity of current formalisms, and to test numerical simulations at the semi empirical and density functional levels. In this work, we have carried out an experimental and theoretical study combining UV visible, IR, Raman, and Hyper-Rayleigh spectroscopies to extract information concerning the geometry, the electronic structure, and the NLO response of our compounds. In particular, we show that the steric effect is sufficient to push the chromophore to the full zwitterionic limit. More generally, the approach we followed here shows great potential in probing chromophore-environment interactions.
Multiband metamaterial-inspired antenna (2014)

Coupling magnetic metamaterial cells with half-loop antenna not only makes the resulting antenna operates at a very lower frequency but also focuses the radiation pattern in one direction instead of having a null. Adding one Split Ring Resonators (SRR) cell behind a half-loop antenna permits to have multiband antenna behaviour. The lower frequency depends mainly on the dimension of the SRR cell and the higher one is related to the resonance frequency of the half-loop antenna alone.
Creating a patch and vulnerability management program (2005)

The Information Technology Laboratory (ITL) at the National Institute of Standards and Technology (NIST) promotes the U.S. economy and public welfare by providing technical leadership for the nation's measurement and standards infrastructure.ITL develops tests, test methods, reference data, proof of concept implementations, and technical analysis to advance the development and productive use of information technology.ITL's responsibilities include the development of technical, physical, administrative, and management standards and guidelines for the cost-effective security and privacy of sensitive unclassified information in Federal computer systems.This Special Publication 800-series reports on ITL's research, guidance, and outreach efforts in computer security and its collaborative activities with industry, government, and academic organizations.Certain commercial entities, equipment, or materials may be identified in this document in order to describe an experimental procedure or concept adequately.Such identification is not intended to imply
Printed transition for SIW horn antennas &#x2014; Analytical model (2012)

A printed transition is proposed to overcome problems limiting the performances of SIW horn antennas when built in thin substrates (thickness <; λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> /10). An analytical model to analyze its behavior is given along with design guidelines. The development of a possible transmission line model is also presented. This transition is associated with a H-plane sectoral SIW horn antenna to both show the validity of the proposed model and the significant improvements it can bring in terms of matching, bandwidth and radiation.
Web information extraction based on IEBIDTech (2012)

Based on the survey of contemporary web information extraction theory, this paper studies the frequently-discussed but insufficiently-solved problem: data extracting from web pages containing several structured records, and proposes a new approach called IEBIDTech(Information Extraction based on Improved Dom Tree) which is mainly composed of three steps. At step 1, the given page is initially segmented into several blocks according to html delimiters after the transformation of a DOM tree, and the redundant blocks are subsequently removed, which is then followed by the induction of extraction rules at step 2 and the extraction of structured data at step 3. Large numbers of experiments from diverse domains' web pages show that both recall and precision rates are greater than 90%. That is this approach is able to extract data more accurately.
VDTs (1991)

As the use of video display terminals (VDTs) has expanded, questions have been raised as to whether working at a VDT affects the risk of adverse pregnancy outcome. A particular focus for these questions has been the very low frequency (VLF) magnetic field produced by a VDT's horizontal deflection coil. VDTs also produce VLF electric fields, extremely low frequency (ELF) electric and magnetic fields, and static electric fields, Ten studies of pregnancy outcome in VDT operators have been conducted in six countries, and with one exception, none has concluded that magnetic fields from VDTs may predispose pregnant operators to spontaneous abortion or congenital malformation. The epidemiologic studies conducted thus far do not provide a basis for concluding that VDT work and adverse pregnancy outcome are associated. Studies of fetal resorptions and malformations in rodents exposed to VLF magnetic fields have produced inconsistent findings. Two laboratories in Sweden that studied mice have reported positive results, one laboratory showing field-related malformations (but not resorptions) and the other showing field-related resorptions (but not malformations). Two Canadian laboratories have reported negative results in rats and mice. Studies of avian embryos have also yielded inconsistent results, but lacking a maternal-fetal placental interface, avian embryos are a questionable model for evaluating human reproductive risks. Finally, VLF electric and magnetic fields measured at the operator position are in compliance with field strength standards and guidelines that have been established around the world.
Control of Pathogenic and Spoilage Microorganisms in Fresh‐cut Fruits and Fruit Juices by Traditional and Alternative Natural Antimicrobials (2009)

Traditional antimicrobials have been extensively used for many years. However, consumers are currently demanding wholesome, fresh-like, and safe foods without addition of chemically synthesized preservatives. The application of novel natural antimicrobials to assure safety of fresh-cut fruits and unpasteurized juices while preventing quality loss is a promising alternative. The effectiveness of these natural substances added to fruit derivatives has been studied by different researchers. Antimicrobials of animal (lactoperoxidase, lysozyme, and chitosan), plant (essential oils, aldehydes, esters, herbs, and spices), and microbial origin (nisin) can be used to effectively reduce pathogenic and spoilage microorganisms in fresh-cut fruits and fruit juices. Nevertheless, the use of these compounds at a commercial level is still limited due to several factors such as impact on sensory attributes or, in some cases, regulatory issues concerning their use. Therefore, extensive research on the effects of each antimicrobial on food sensory characteristics is still needed so that antimicrobial substances of natural origin can be regarded as feasible alternatives to synthetic ones.
Breast cancer risk score: a data mining approach to improve readability (2011)

Abstract — According to the World Health Organization, starting from 2010, cancer will become the leading cause of death worldwide. Prevention of major cancer localizations through a quantified assessment of risk factors is a major concern in order to decrease their impact in our society. Our objective is to test the performances of a modeling method easily readable by a physician. In this article, we follow a data mining process to build a reliable assessment tool for primary breast cancer risk. A k-nearest-neighbor algorithm is used to compute a risk score for different profiles from a public database. We empirically show that it is possible to achieve the same performances than logistic regressions with less parameters and a more easily readable model. The process includes the intervention of a domain expert who helps to select one of the numerous model variations by combining at best, physician expectations and performances. A risk score is made up of four parameters: age, breast density, number of affected first degree relatives and prone to breast biopsy. Detection performance measured with the area under the ROC curve is 0.637. I.
Supplementary Dataset Legends from Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition (2023)

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The C-terminal cavity of the Na,K-ATPase analyzed by docking and electrophysiology (2012)

The Na,K-ATPase is essential to all animals, since it maintains the electrochemical gradients that energize the plasma membrane. Naturally occurring inhibitors of the pump from plants have been used pharmaceutically in cardiac treatment for centuries. The inhibitors block the pump by binding on its extracellular side and thereby locking it. To explore the possibilities for designing an alternative way of targeting the pump function, we have examined the structural requirements for binding to a pocket that accommodates the two C-terminal residues, YY, in the crystal structures of the pump. To cover the sample space of two residues, we first performed docking studies with the 400 possible dipeptides. For validation of the in silico predictions, pumps with 13 dipeptide sequences replacing the C-terminal YY were expressed in Xenopus laevis oocytes and examined with electrophysiology. Our data show a significant correlation between the docking scores from two different methods and the experimentally determined sodium affinities, which strengthens the previous hypothesis that sodium binding is coupled to docking of the C-terminus. From the dipeptides that dock the best and better than wild-type YY, it may therefore be possible to develop specific drugs targeting a previously unexplored binding pocket in the sodium pump.
Redox-Noninnocence of the S,S‘-Coordinated Ligands in Bis(benzene-1,2-dithiolato)iron Complexes (2005)

The electronic structures of complexes of iron containing two S,S'-coordinated benzene-1,2-dithiolate, (L)(2)(-), or 3,5-di-tert-butyl-1,2-benzenedithiolate, (L(Bu))(2)(-), ligands have been elucidated in depth by electronic absorption, infrared, X-band EPR, and Mossbauer spectroscopies. It is conclusively shown that, in contrast to earlier reports, high-valent iron(IV) (d(4), S = 1) is not accessible in this chemistry. Instead, the S,S'-coordinated radical monoanions (L(*))(1)(-) and/or (L(Bu)(*))(1)(-) prevail. Thus, five-coordinate [Fe(L)(2)(PMe(3))] has an electronic structure which is best described as [Fe(III)(L)(L(*))(PMe(3))] where the observed triplet ground state of the molecule is attained via intramolecular, strong antiferromagnetic spin coupling between an intermediate spin ferric ion (S(Fe) = (3)/(2)) and a ligand radical (L(*))(1)(-) (S(rad) = (1)/(2)). The following complexes containing only benzene-1,2-dithiolate(2-) ligands have been synthesized, and their electronic structures have been studied in detail: [NH(C(2)H(5))(3)](2)[Fe(II)(L)(2)] (1), [N(n-Bu)(4)](2)[Fe(III)(2)(L)(4)] (2), [N(n-Bu)(4)](2)[Fe(III)(2)(L(Bu))(4)] (3); [P(CH(3))Ph(3)][Fe(III)(L)(2)(t-Bu-py)] (4) where t-Bu-py is 4-tert-butylpyridine. Complexes containing an Fe(III)(L(*))(L)- or Fe(III)(L(Bu))(L(Bu)(*))- moiety are [N(n-Bu)(4)][Fe(III)(2)(L(Bu))(3)(L(Bu)(*))] (3(ox)()), [Fe(III)(L)(L(*))(t-Bu-py)] (4(ox)()), [Fe(III)(L(Bu))(L(Bu)(*))(PMe(3))] (7), [Fe(III)(L(Bu))(L(Bu)(*))(PMe(3))(2)] (8), and [Fe(III)(L(Bu))(L(Bu)(*))(PPr(3))] (9), where Pr represents the n-propyl substituent. Complexes 2, 3(ox)(), 4, [Fe(III)(L)(L(*))(PMe(3))(2)] (6), and 9 have been structurally characterized by X-ray crystallography.
Source Location Estimation via Compressed Sensing using UAVs (2021)

Herein, a new source location estimation method the iterative shrinkage-thresholding algorithm (ISTA), which is a compressed sensing method, and unmanned aerial vehicles (UAVs) is presented. By using the source location information of the primary system, secondary use of the unused vacant frequencies is possible. The proposed source location estimation method utilizes a virtual array using UAVs; however the estimation took considerable time. Therefore, we evaluate the effect of the source location estimation method using a small number of antennas by ISTA and clarify this effect.
Clinical and Biologic Activity of an Estrogenic Herbal Combination (PC-SPES) in Prostate Cancer (1998)

PC-SPES has potent estrogenic activity. The use of this unregulated mixture of herbs may confound the results of standard or experimental therapies and may produce clinically significant adverse effects.
Successful Simultaneous Liver-Kidney Transplantation in the Presence of Multiple High-Titered Class I and II Antidonor HLA Antibodies (2016)

The results of simultaneous liver-kidney transplants in highly sensitized recipients have been controversial in terms of antibody-mediated rejection and kidney allograft outcomes. This case report provides a detailed and sophisticated documentation of histocompatibility and pathologic data in a simultaneous liver-kidney transplant performed in a recipient with multiple high-titered class I and II antidonor HLA antibodies and a strongly positive cytotoxic crossmatch. Patient received induction with steroids, rituximab, and eculizumab without lymphocyte depleting agents. The kidney transplant was delayed by 6 hours after the liver transplant to allow more time to the liver allograft to "absorb" donor-specific antibodies (DSA). Interestingly, the liver allograft did not prevent immediate antibody-mediated injury to the kidney allograft in this highly sensitized recipient. Anti-HLA single antigen bead analysis of liver and kidney allograft biopsy eluates revealed deposition of both class I and II DSA in both liver and kidney transplants during the first 2 weeks after transplant. Afterward, both liver and kidney allograft functions improved and remained normal after a year with progressive reduction in serum DSA values.
Tomographic reconstruction of near-borehole slowness using refracted borehole sonic arrivals (1993)

Abstract Two-dimensional (2-D) reconstructions of the near-borehole slowness field are computed using arrival times of refracted borehole sonic arrivals. First-arrival traveltimes, derived from both computer simulations and field data from full-waveform sonic tools, were inverted for the near-borehole formation slowness both axially along the borehole and radially away from the borehole. The inversion is nonlinear; the solution is obtained by means of a series of linear inversions followed by provisional ray tracings. Each iteration involves the application of a tomographic reconstruction algorithm similar to those used in seismic cross-well tomography or medical imaging applications.The technique was demonstrated using ray-theoretic examples to simulate radial variations in slowness. In addition, full-waveforms were generated using two-and-a-half-dimensional (2.5-D) FDM computer models. The finite-difference method (FDM) computer models were used to test the validity of the ray-theoretic approximation used in the inversion scheme and to simulate the full-waveform sonic tool response for both radial and axial changes in formation properties.Field data examples highlighted radial changes in formation slowness caused by two separate mechanisms: water take up by swelling shales and the mechanical breakdown of the near-borehole rock resulting from stress relief caused by the drilling process. Finally, refracted sonic arrivals from near-borehole bed boundaries were identified in a horizontal well setting. Using refractions arriving beyond the headwave, a 2-D map of formation slowness was computed in the reservoir away from the borehole. Interpretation of the slowness map resulted in an estimation of the stand-off of the horizontal borehole from the reservoir boundary.
Sequence-Corrected 15N "Random Coil" Chemical Shifts (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSequence-Corrected 15N "Random Coil" Chemical ShiftsDaniel Braun, Gerhard Wider, and Kurt WuethrichCite this: J. Am. Chem. Soc. 1994, 116, 19, 8466–8469Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/ja00098a005https://doi.org/10.1021/ja00098a005research-articleACS PublicationsRequest reuse permissionsArticle Views489Altmetric-Citations115LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An approach to fully differential circuit design without common-mode feedback (1996)

Fully differential transconductance structures allow for greater linearity than their single-ended counterparts. The disadvantage is the need for common-mode feedback circuitry, which complicates the design and introduces additional design problems and constraints. In this paper we present and analyze a new technique for designing fully differential transconductance structures which removes the need for common-mode feedback by instead forming two independent nonlinear transconductance blocks, each of whose common-mode output voltage is well defined by the differential feedback.
The Rice Oligonucleotide Array Database: an atlas of rice gene expression (2012)

The Rice Oligonucleotide Array Database provides comprehensive gene expression profiles for all rice genes, and will be a useful resource for researchers of rice and other grass species.
AMERICAN BOARD OF ORTHOPAEDIC SURGERY PRACTICE OF THE ORTHOPAEDIC SURGEON (2006)

Garrett, William E. Jr. MD; Swiontkowski, Marc F. MD; Weinstein, James N. DO, MS; Callaghan, John MD; Rosier, Randy N. MD, PHD; Berry, Daniel J. MD; Harrast, John PHD; Derosa, G. Paul MD; Executive Director; the Research Committee of The American Board of Orthopaedic Surgery Author Information
Une analyse bibliométrique de la revue Études de communication (2017)

Editee par le laboratoire GERiiCO a l’Universite de Lille 3, la revue scientifique internationale francophone en sciences de l’information et de la communication, Etudes de communication, a connu plusieurs evolutions depuis sa creation en 1982 : evolution de son nom, evolution des thematiques de recherche et evolution de la ligne editoriale. Ces evolutions sont mises en place dans l’objectif d’ouvrir la visibilite de la revue au plan international. A partir des methodes bibliometriques et notamment l’analyse des citations, l’enjeu du stage et de ce travail de recherche est de montrer que ces evolutions ont un impact sur les auteurs publiant dans la revue et sur leurs citations.
ChemInform Abstract: Stereoselective Synthesis of the Bicyclic Core Structure of the Highly Oxidized Sesquiterpene Neoliacinic Acid. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Protein stains for proteomic applications: Which, when, why? (2006)

This review recollects literature data on sensitivity and dynamic range for the most commonly used colorimetric and fluorescent dyes for general protein staining, and summarizes procedures for the most common PTM-specific detection methods. It also compiles some important points to be considered in imaging and evaluation. In addition to theoretical considerations, examples are provided to illustrate differential staining of specific proteins with different detection methods. This includes a large body of original data on the comparative evaluation of several pre- and post-electrophoresis stains used in parallel on a single specimen, horse serum run in 2-DE (IPG-DALT). A number of proteins/protein spots are found to be over- or under-revealed with some of the staining procedures.