gebhart/patrepeval huggingface dataset:
A Stream-Oriented Power Management Protocol for Low Duty Cycle Sensor Network Applications (2005)

Most power management protocols are packet-based and optimized for applications with mostly asynchronous (i.e. unexpected) traffic. We present AppSleep, a stream-oriented power management protocol for latency tolerant sensor network applications. For this class of applications, AppSleep demonstrates an over 3/spl times/ lifetime gain over B-MAC and SMAC. AppSleep leverages application characteristics in order to take advantage of periods of high latency tolerance to put the network to sleep for extended periods of time, while still facilitating low latency responses when required. AppSleep also gives applications the flexibility to efficiently and effectively trade latency for energy when desired, and enables energy efficient multi-fragment unicast communication by only keeping the active route awake. We also present Adaptive AppSleep, an application driven addition to AppSleep which supports varying latency requirements while still maximizing energy efficiency. Our evaluation demonstrates that for an overlooked class of applications, stream-oriented power management protocols such as AppSleep outperform packet-based protocols such as B-MAC and S-MAC.
Low-Dose Interleukin-2 Immunotherapy Does Not Improve Outcome of Patients Age 60 Years and Older With Acute Myeloid Leukemia in First Complete Remission: Cancer and Leukemia Group B Study 9720 (2008)

Low-dose rIL-2 maintenance immunotherapy is not a successful strategy in older AML patients.
Caspase Inhibition Enhances Ischemic Tolerance of Fasciocutaneous Flaps (2005)

Pretreatment of fasciocutaneous flaps with a free radical scavenger alone or in combination with a caspase inhibitor significantly increases the flap's tolerance of primary ischemia. The added benefit of the caspase inhibitor suggests that apoptosis plays an important role in ischemia-reperfusion injury in soft tissue flaps.
Quantifications of the Two “Flavours” of El Niño using Upper-Ocean Heat Content (2014)

The sea surface temperature (SST) or sea level pressure (SLP) has usually been used to measure the strength of El Niño–Southern Oscillation (ENSO) events. In this study, two new indices, based on the upper-ocean heat content (HC), are proposed to quantify the two “flavours” of El Niño (i.e., the Cold Tongue El Niño (CTE) and Warm Pool El Niño (WPE)). Compared with traditional SST or SLP indices, the new HC-based indices can distinguish CTE and WPE events much better and also represent the two leading modes of the interannual variability of the atmosphere–ocean coupled system in the tropical Indo-Pacific region. The two leading modes are obtained by performing multivariate Empirical Orthogonal Function analysis on two oceanic variables (SST and HC) over the tropical Pacific (30°S–30°N, 120°E–80°W) and six atmospheric variables (outgoing longwave radiation, SLP, streamfunction, and velocity potential at 850 hPa and 200 hPa) over the tropical Indo-Pacific region (30°S–30°N, 60°E–80°W) for the period 1980–2010. Because the two new HC-based indices are capable of better depicting coherent variations between the ocean and atmosphere, they can provide a supplementary tool for ENSO monitoring of and climate research into the two flavours of El Niño.
Amaranzole A, a New N-Imidazolyl Steroid from Phorbas amaranthus (2007)

An unprecedented 24-N-imidazolyl steroidal alkaloid, amaranzole A, was isolated from a tropical sponge, Phorbas amaranthus. The structure was solved by interpretation of MS, NMR, including a novel exciton-coupled CD spectrum due to an allyl imidazole, and comparison with model compounds.
RAD51 Plays a Crucial Role in Halting Cell Death Program Induced by Ionizing Radiation in Bovine Oocytes1 (2011)

Reproductive health of humans and animals exposed to daily irradiants from solar/cosmic particles remains largely understudied. We evaluated the sensitivities of bovine and mouse oocytes to bombardment by krypton-78 (1 Gy) or ultraviolet B (UV-B; 100 microjoules). Mouse oocytes responded to irradiation by undergoing massive activation of caspases, rapid loss of energy without cytochrome-c release, and subsequent necrotic death. In contrast, bovine oocytes became positive for annexin-V, exhibited cytochrome-c release, and displayed mild activation of caspases and downstream DNAses but with the absence of a complete cell death program; therefore, cytoplasmic fragmentation was never observed. However, massive cytoplasmic fragmentation and increased DNA damage were induced experimentally by both inhibiting RAD51 and increasing caspase 3 activity before irradiation. Microinjection of recombinant human RAD51 prior to irradiation markedly decreased both cytoplasmic fragmentation and DNA damage in both bovine and mouse oocytes. RAD51 response to damaged DNA occurred faster in bovine oocytes than in mouse oocytes. Therefore, we conclude that upon exposure to irradiation, bovine oocytes create a physiologically indeterminate state of partial cell death, attributed to rapid induction of DNA repair and low activation of caspases. The persistence of these damaged cells may represent an adaptive mechanism with potential implications for livestock productivity and long-term health risks associated with human activity in space.
Spectral Energy Distribution of the International Commission on Illumination Light Sources A, B, and C* (1953)

Standard light sources A, B, and C were adopted by the International Commission on Illumination (C.I.E.) in 1931 for the colorimetry of materials. Source A is an incandescent lamp operated at 2854°K. Sources B and C, representative of average noon sunlight and average daylight, respectively, are produced by passing radiant flux from source A through specified Davis-Gibson filters described in Bureau of Standards Miscellaneous Publication M114 (1931).The C.I.E. published relative energy data only from 370 to 720 mµ. The present paper gives data for these sources in the ultraviolet and extends the data in the red to 780 mµ. The new data were reported through the U. S. Secretariat Committee to the C.I.E. at its 1951 meeting. The values in the ultraviolet were reported to the Optical Society of America at its March, 1952, meeting.
A Scaling Study of NO Formation in Turbulent Diffusion Flames of Hydrogen Burning in Air (1973)

Experimental composition maps have been obtained of four H2-air turbulent diffusion flames of varying diameter but constant Reynolds number. Nitric oxide levels were found to scale with a characteristic “jet time,” modified to include the effects of buoyancy on flame shape. A comparison is made between present measurements, those of Kent and Bilger (1972), and a simple model of NO formation. The results suggest that the rate of NO formation is not predictable on the basis of fluctuating adiabatic equilibrium kinetics but requires consideration of turbulent combustion in detail and possibly the effects of excess radical concentrations.
Axillary Lymph Node Nanometastases Are Prognostic Factors for Disease-Free Survival and Metastatic Relapse in Breast Cancer Patients (2006)

Nanometastases are a strong risk factor for disease-free survival and for metastatic relapse. These findings support the inclusion of procedures for nanometastasis detection in tumor-node-metastasis staging.
Supplementary Methods and Synthesis of RED-106 from CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models (2023)

&lt;p&gt;Supplementary Methods and Synthesis of RED-106&lt;/p&gt;
Hutchinson–Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody (2006)

Hutchinson-Gilford progeria syndrome (HGPS; Online Mendelian Inheritance in Man accession no. 176670) is a rare disorder that is characterized by segmental premature aging and death between 7 and 20 years of age from severe premature atherosclerosis. Mutations in the LMNA gene are responsible for this syndrome. Approximately 80% of HGPS cases are caused by a G608 (GGC-->GGT) mutation within exon 11 of LMNA, which elicits a deletion of 50 aa near the C terminus of prelamin A. In this article, we present evidence that the mutant lamin A (progerin) accumulates in the nucleus in a cellular age-dependent manner. In human HGPS fibroblast cultures, we observed, concomitantly to nuclear progerin accumulation, severe nuclear envelope deformations and invaginations preventable by farnesyltransferase inhibition. Nuclear alterations affect cell-cycle progression and cell migration and elicit premature senescence. Strikingly, skin biopsy sections from a subject with HGPS showed that the truncated lamin A accumulates primarily in the nuclei of vascular cells. This finding suggests that accumulation of progerin is directly involved in vascular disease in progeria.
Numerical Investigation of Externally Venting Flame Characteristics in a Corridor-FaÃ§ade Configuration (2019)

Understanding of the physics and mechanisms of fire development and Externally Venting Flames (EVF) in corridor-like enclosures is fundamental to studying fire spread to adjacent floors in high-rise buildings. The main scope of this study is to investigate the burning behaviour of a liquid fuel pool fire in a corridorlike enclosure, to identify the key factors influencing EVF characteristics, EVF impact on faÃ§ades and to assess the ability of currently available CFD tools to adequately describe corridor-faÃ§ade fires. The Fire Dynamics Simulator (FDS) CFD tool is used for the numerical simulations which are compared and validated against medium scale experimental data on corridor-faÃ§ade fire experiments. Experimental results suggest that, in the interior of the corridor, good qualitative and occasionally quantitative agreement is observed for the gas temperatures. When the burner is positioned at the back of the corridor, resulting in increased temperatures at the interior, FDS generally underpredicts the combustion zone and the fire plume seems tilting at the rear of the corridor. The performance of the CFD tool in predicting EVF gas temperatures and heat flux to the adjacent faÃ§ade is improved in larger opening sizes. Regarding the heat flux at the exposed surface of the faÃ§ade, good quantitative agreement is observed, especially at lower heights near the opening.
Voluntary Running Exercise Ameliorates Muscle Loss in Mice (2007)

Both spaceflight and bed rest studies are known to cause substantial muscle loss in humans. Of particular interest in atrophy studies is the postural, slow-twitch fiber soleus muscle. It has been demonstrated that during periods of disuse, slow-twitch fibers undergo fiber type switching and morph into fast-twitch fibers [1]. Alternatively, when exercise is prescribed, there is switching of fast-to slow-twitch fibers [2], indicating a profound adaptability of the muscle to exercise.
C−H Activation from Iron(II)‐Nitroxido Complexes (2017)

Abstract The reaction of nitroxyl radicals TEMPO (2,2′,6,6′‐tetramethylpiperidinyloxyl) and AZADO (2‐azaadamantane‐N‐oxyl) with an iron(I) synthon affords iron(II)‐nitroxido complexes ( Ar L)Fe(κ 1 ‐TEMPO) and ( Ar L)Fe(κ 2 ‐N,O‐AZADO) ( Ar L=1,9‐(2,4,6‐Ph 3 C 6 H 2 ) 2 ‐5‐mesityldipyrromethene). Both high‐spin iron(II)‐nitroxido species are stable in the absence of weak C−H bonds, but decay via N−O bond homolysis to ferrous or ferric iron hydroxides in the presence of 1,4‐cyclohexadiene. Whereas ( Ar L)Fe(κ 1 ‐TEMPO) reacts to give a diferrous hydroxide [( Ar L)Fe] 2 (μ‐OH) 2 , the reaction of four‐coordinate ( Ar L)Fe(κ 2 ‐N,O‐AZADO) with hydrogen atom donors yields ferric hydroxide ( Ar L)Fe(OH)(AZAD). Mechanistic experiments reveal saturation behavior in C−H substrate and are consistent with rate‐determining hydrogen atom transfer.
Conformational Asymmetry of a Linear Perfluoroalkyl Chain in Solution. Dynamic Fluorine-19 NMR Spectroscopy of the Perfluoro-n-alkanes Carrying a Chiral End-Group as a Probe of Magnetic Nonequivalence (1992)

Abstract The 470 MHz 19F NMR spectra of 1-perfluorohexyl-1-phenylethanol (1a) were measured in toluene-d8. At 0 °C and the lower temperatures, magnetic nonequivalence was observed for the two fluorine nuclei in the CF2 group adjacent to the asymmetric carbon atom and for those in the subsequent four CF2 groups. The extent of the nonequivalence was highly dependent on temperature. 1a and the perfluorooctyl- and perfluorodecyl-homologues were optically resolved and specific rotation of the pure (−)-isomers were examined from the viewpoint of the conformational asymmetry induced on the perfluoroalkyl chain.
How to Hackathon (2016)

Hackathons are events where people who are not normally collocated converge for a few days to write code together. Hackathons, it seems, are everywhere. We know that long- term collocation helps advance technical work and facilitate enduring interpersonal relationships, but can similar benefits come from brief, hackathon-style collocation? How do participants spend their time preparing, working face-to- face, and following through these brief encounters? Do the activities participants select suggest a tradeoff between the social and technical benefits of collocation? We present results from a multiple-case study that suggest the way that hackathon-style collocation advances technical work varies across technical domain, community structure, and expertise of participants. Building social ties, in contrast, seems relatively constant across hackathons. Results from different hackathon team formation strategies suggest a tradeoff between advancing technical work and building social ties. Our findings have implications for technology support that needs to be in place for hackathons and for understanding the role of brief interludes of collocation in loosely-coupled, geographically distributed work.
Blood GroupABOGenotyping in Paternity Testing (2012)

BACKGROUND: The ABO blood groups result from DNA sequence variations, predominantly single nucleotide and insertion/deletion polymorphisms (SNPs and indels), in the ABO gene encoding a glycosyltransferase. The ABO blood groups A(1), A(2), B and O predominantly result from the wild type allele A1 and the major gene variants that are characterized by four diallelic markers (261G>del, 802G>A, 803G>C, 1061C>del). Here, we were interested to evaluate the impact of ABO genotyping compared to ABO phenotyping in paternity testing. METHODS: The major ABO alleles were determined by PCR amplification with sequence-specific primers (PCR-SSP) in a representative sample of 1,335 blood donors. The genotypes were compared to the ABO blood groups registered in the blood donor files. Then, the ABO phenotypes and genotypes were determined in 95 paternity trio cases that have been investigated by 12 short tandem repeat (STR) markers before. We compared statistical parameters (PL, paternity likelihood; PE, power of exclusion) of both blood grouping approaches. RESULTS: The prevalence of the major ABO alleles and genotypes corresponded to the expected occurrence of ABO blood groups in a Caucasian population. The low resolution genotyping of 4 diallelic markers revealed a correct genotype-phenotype correlation in 1,331 of 1,335 samples (99.7%). In 60 paternity trios with confirmed paternity of the alleged father based on STR analysis both PL and PE of the ABO genotype was significantly higher than of the ABO phenotype. In 12 of 35 exclusion cases (34.3%) the ABO genotype also excluded the alleged father, whereas the ABO phenotype excluded the alleged father only in 7 cases (20%). CONCLUSION: In paternity testing ABO genotyping is superior to ABO phenotyping with regard to PL and PE, however, ABO genotyping is not sufficient for valid paternity testing. Due to the much lower mutation rate compared to STR markers, blood group SNPs in addition to anonymous SNPs could be considered for future kinship analysis and genetic identity testing.
Seizure-Related Gene 6 (Sez-6) in Amacrine Cells of the Rodent Retina and the Consequence of Gene Deletion (2009)

In summary, we have reported the detailed expression pattern of a novel retinal marker with broad cell specificity, useful for retinal characterization in rodent experimental models. Retinal morphology, ganglion cell dendritic branching and ERG waveforms appeared normal in the Sez-6 knockout mouse suggesting that, in spite of widespread expression of Sez-6, retinal function in the absence of Sez-6 is not affected.
The history of real-ear attenuation at threshold since 1957 with emphasis on the most recent ANSI S12.6-2016 and CSA Z94.2-2014 standards (2017)

The American standard specifying the procedure for the measurement of real ear attenuation at threshold (REAT), often termed the gold standard in measuring hearing protector attenuation, was approved last year as an updated version, ANSI 12.6-2016. REAT was first standardized worldwide in the late 1950s in an American standard ANSI Z24.22-1957 and the method has evolved with time. Changes have affected the electroacoustic requirements for the sound field, instrumentation, audiometric method, and permissible background noise, but more importantly have also improved the specification of how the experimenter works with and fits the test subjects. So too, estimates of uncertainty are now included, and in the 2016 version they have been clarified and brought into harmony with ISO 4869 1. The ANSI standard also impacts Z94 since the latter standard references S12.6 for specification of the Canadian methodology. The author, who has been the chair since 1985 of the ANSI working group responsible for S12.6 and a member of the CSA working group responsible for Z94 since 1981, will compare and contrast the various methods and the Z94 requirements, and present representative data as well as a discussion of the expanded uncertainties that are specified in the most recent ANSI and ISO documents. Those values, for the 1/3 octave band test bands from 125 Hz to 8000 Hz, vary from approximately 1.5 2 dB for earmuffs and 2-3 dB for earplugs for within-laboratory testing, to 4-6 dB for earmuffs and 6.5-8 dB for earplugs for between laboratory measurements.
Scalar modes and coupling characteristics of eight-port waveguide couplers (1989)

The scalar modes and the coupling characteristics of an eight-port waveguide coupler consisting of four parallel single-mode waveguides are discussed. The analysis is based on a rectangular waveguide model which has been known to give accurate results in the case of two waveguide directional couplers. A classification of its various scalar modes is also given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Tables from Preclinical Efficacy of the Anti-Hepatocyte Growth Factor Antibody Ficlatuzumab in a Mouse Brain Orthotopic Glioma Model Evaluated by Bioluminescence, PET, and MRI (2023)

&lt;p&gt;Supplementary Tables - PDF file 86K, Supplementary Table 1. Overall results of 2nd experiment shown as percent change from baseline by experimental group: Control, Low Dose, and High Dose. Supplementary Table 2. Mitotic activity and Ki-67 labeling in the 3 animals from each group that had their brain excised for pathology. Mitotic activity was assessed, by counting mitotic figures in ten high powered (400x) fields, in each of the animals in the most proliferative areas of tumor. Ki-67 labeling was assessed semi-quantitatively&lt;/p&gt;
Structure of Vinyl Polymers. V.1 Some Reactions of the Polymer of Methyl Vinyl Ketone (1939)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of Vinyl Polymers. V.1 Some Reactions of the Polymer of Methyl Vinyl KetoneC. S. Marvel and Charles L. LevesqueCite this: J. Am. Chem. Soc. 1939, 61, 11, 3234Publication Date (Print):November 1, 1939Publication History Published online1 May 2002Published inissue 1 November 1939https://pubs.acs.org/doi/10.1021/ja01266a501https://doi.org/10.1021/ja01266a501research-articleACS PublicationsRequest reuse permissionsArticle Views39Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Autologous stem cell transplantation vs bortezomib based chemotheraphy for the first‐line treatment of systemic light chain amyloidosis in the UK (2021)

This small retrospective study suggests that there is no clear survival advantage of ASCT over bortezomib therapy. A prospective randomised controlled trial evaluating ASCT in AL amyloidosis is critically needed.
Genetic association of gemcitabine/carboplatin-induced leukopenia and neutropenia in non-small cell lung cancer patients using whole-exome sequencing (2020)

We have identified and partially validated genetic biomarkers in SNVs and genes correlated to gemcitabine/carboplatin-induced leukopenia and neutropenia and created wGRS models for predicting the risk of chemotherapy-induced hematological toxicity. These results provide a strong foundation for further studies of chemotherapy-induced toxicity.
일제강점기 체화(體化)된 황국신민의례와 일제의 ‘착한 근대 아동’ 만들기: 경성(京城)의 소학교를 중심으로 (2020)

이 논문은 일제강점기 경성의 주요 소학교의 시간 구성과 교육 정책에서 강조된 황국신민화 교육이 학교 의례의 수행으로 표출된 과정에 대해 분석함으로써 일제의 식민지 초등 교육에서 추구되는 ‘착한 근대 아동’이 지닌 함의에 대해 고찰하는 것이다. 일제강점기 식민지국가 이데올로기는 학교의 시간 구성과 학교 의례에 직접적으로 반영되어 나타났으며, 경성의 조선인 아동이 다니는 소학교는 일제의 식민정책과 황국신민화교육을 가장 우선적으로 반영시키는 제도적 장치가 되었다. 식민지 국가의 시간 구성 속에서 일제의 국가 의례와 수신교육은 점차 강화되었다. 일제가 국가 시간체제 내에서 소학교 교육을 통해 조선의 아동에게 주입시키고자 한 ‘근대 아동’은 서구의 근대 국민의 모델을 일제의 식민지 국가 이데올로기에 의해 변용시킨 ‘황국신민’이다. 일제는 경성의 주요 소학교에서 반복되는 국가의례의 수행을 통해 아동의 일상생활 깊숙이 황국신민의식이 자리잡을 수 있도록 소학교 의례의 시간을 정교하게 구성하였다. 일제강점기 말기로 갈수록 경성의 소학교에서는 수신 교육을 전면에 내세우게 되었고, 이와 연계되어 일본어의 상용화, 신사참배 의례, 봉안전 의례, 조회와 국가축제일의례의 수행이 점차 심화되었다. 경성의 소학교에서는 조선의 아동을 ‘일제의 황국신민’으로 육성시키고자 하였으며, 아동의 매일의 일상속에서 국가 이데올로기가 함의된 황국신민의례는 이들의 삶과 결부되며 점차 자연스럽게 체화되어갔다. 이로써 일제강점기경성의 소학교 아동은 일본의 언어와 의례를 수행하며 일제의 황국신민이 되기 위해 학교의 시간과 규율을 잘 지키는 ‘착한 근대 아동’으로서 교육받았다.
Improving Digital Video Commercial Detectors With Genetic Algorithms (2002)

The advent of digital video offers many opportunities to add features that enhance the viewing experience. One much-discussed feature is the possibility that commercials might be automatically detected in the video stream. We report on initial experiments with a class of commercial detection algorithms and show how their performance can be enhanced by applying genetic search to the optimization of some of their internal parameters. We show how a scalar genetic algorithm can locate sets of parameters in a multi-objective space (precision and recall) that outperform the values selected by an expert engineer. While a useful observation in itself, we also argue that this approach may be a necessity as the features that distinguish commercials from other video content will certainly vary with video format, the country of broadcast and possibly over time. We present the results of optimizing a commercial detection algorithm for different data sets and parameter sets. We are convinced that GAs drastically improved our approach and enabled fast prototyping and performance tuning of commercial detection algorithms.