gebhart/patrepeval huggingface dataset:
PAI-1 induces cell detachment, downregulates nucleophosmin (B23) and fortilin (TCTP) in LnCAP prostate cancer cells (2007)

Plasminogen activator inhibitor (PAI-1) is an anticancer agent that inhibits plasmin driven proteolysis, limiting angiogenesis and metastasis. In low concentrations it could induce cancer cell motility by interacting with urokinase (uPA), its receptor (uPAR), vitronectin and integrins. Active PAI-1 binds to uPA forming a complex with uPAR, while the latent form of PAI-1 does not. PAI-1 is found in both forms in the circulation. It is not clear which form acts as an anticancer agent and how it interacts with malignant cells. To investigate how these forms reduce angiogenesis or metastasis, we have created PAI-1 cysteine mutants in the active conformation (VLHL PAI-1) with an extended half-life that reaches approximately 700 h and its R369A mutant, which has an active conformation but cannot bind to uPA (VLHLNS PAI-1). Both VLHL PAI-1s convert into the latent form when treated with a reducing agent (DTT) that breaks disulfide bridges. Unexpectedly, during routine investigation of LnCAP cell proliferation, we have found that cells detach from the culture vessels regardless of PAI-1 conformation or activity. Further investigation showed that treatment of cancer cells with VLHL PAI-1 downregulated nucleophosmin, while all forms of PAI-1 downregulated fortilin. These two proteins are implicated in important cellular processes (cell growth, cell cycle, malignant transformation). This suggests that PAI-1, in addition to its well-known anticancer properties, plays an important role in cell signaling. We hope that by exploring PAI-1's structure and function we might be able to understand and separate the different effects of PAI-1 on cancer cells and develop more effective therapeutic strategies in cancer treatment.
Communication-Efficient Distributed Dual Coordinate Ascent (2014)

Communication remains the most significant bottleneck in the performance of distributed optimization algorithms for large-scale machine learning.In this paper, we propose a communication-efficient framework, COCOA, that uses local computation in a primal-dual setting to dramatically reduce the amount of necessary communication.We provide a strong convergence rate analysis for this class of algorithms, as well as experiments on real-world distributed datasets with implementations in Spark.In our experiments, we find that as compared to stateof-the-art mini-batch versions of SGD and SDCA algorithms, COCOA converges to the same .001-accuratesolution quality on average 25 as quickly.* Both authors contributed equally. 1 On typical computers, the latency for accessing data in main memory is in the order of 100 nanoseconds.In contrast, the latency for sending data over a standard network connection is around 250,000 nanoseconds.
Reliable link initialization procedures (1988)

It is known that HDLC (high-level data link control) and other bit-oriented DLC procedures ensure data transmission reliability across noisy transmission media, provided that all frame errors are detected and the link processes are synchronized at initialization. It is shown that the HDLC initialization procedure does not ensure synchronization and allows inadvertent loss of data. Several link initialization procedures are proposed and it is proved that they do ensure synchronization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Design and use of NOMEN, an ontology defining the rules of biological nomenclature (2017)

The most complex nomenclatural databases are developed not from community based efforts but from individuals who have encoded their understanding of the rules of nomenclature into bespoke knowledge-bases. In efforts spanning decades well over 75 types of “status” may to be defined for a single database. Reconciliation of these status types into new, federated systems is nearly always the most difficult aspect of their migration. Nomenclatural data is often recorded in a logically inconsistent manner, for example mixing governed rules and curator annotations. NOMEN (https://github.com/SpeciesFileGroup/nomen) is an Web Ontology Language (OWL) ontology that seeks to address these issues, providing standardized URIs for classes of nomenclatural annotations on taxonomic names (not taxonomic concepts). It includes assertions for the animal (ICZN), plant (ICN), and bacterial (ICNB) codes. NOMEN based assertions can be encoded in a simple graph format, as illustrated in its implementation in TaxonWorks (http://taxonworks.org). We illustrate its application within the migration process of four very large taxonomic databases.
Branwell Bronte; The Art of George Eliot (1962)

Branwell Brontë; The Art of George Eliot Get access Branwell Brontë. By Winifred GÉrin. Nelson. 35s.The Art of George Eliot. By W. J. Harvey. Chatto & Windus. 21s. Gilbert Thomas Gilbert Thomas Search for other works by this author on: Oxford Academic Google Scholar English: Journal of the English Association, Volume 14, Issue 79, Spring 1962, Pages 27–28, https://doi.org/10.1093/english/14.79.27 Published: 01 March 1962
Thermoelectric properties of Zn-In complex chalcogenides (2002)

A ceramic compact of ZnIn/sub 2/S/sub 4/ with spinel structure and another polymorphism of ZnIn/sub 2/S/sub 4/ with a layer structure known as IIIa phase were synthesized by reaction-sintering of the mixed powder of ZnS and In/sub 2/S/sub 3/ at 450/spl deg/C and 800/spl deg/C under Ar (containing 1% H/sub 2/) atmosphere, respectively. Their thermoelectric properties were investigated in the temperature range from 200/spl deg/ to 600/spl deg/C. Power factor of IIIa type was much larger than that of the spinel type, although it was slightly lower than maximum power factor of the oxide homologous compounds ((ZnO)/sub m/In/sub 2/O/sub 3/). To increase the thermoelectric properties of ZnIn/sub 2/S/sub 4/ a c-plane oriented sintered body of IIIa phase was successfully fabricated by a usual ceramic process. The power factor in the direction perpendicular to c-axis was larger than that in the direction parallel to c-axis due to higher electrical conductivity in the former direction.
PPZPMs - a Novel Group of Cyclic Lipodepsipeptides Produced by the Phytophthora alni Associated Strain Pseudomonas sp. JX090307 -the Missing Link between the Viscosin and Amphisin Group (2014)

The closely related to the Pseudomonas orientalis strain Pseudomonas sp. acc. no. JX090307 was isolated from hyphae of the phytopathogenic oomycete Phytophthora alni spp. alni. In in-vitro antagonistic tests, the living bacterium JX090307 and its cell extract showed antibiosis activity against different fungal pathogens of forest tree species, particularly against Verticillium dahliae and some strains of P. alni ssp. alni. Investigating the cell extract of JX090307 by means of LC-ESI-Q-TOF-MS and -MS/MS techniques, more than 30 cyclic lipodepsipeptids (CLPs) were found. 24 of them belong to a novel group of CLPs named PPZPM. The cyclic lipodepsidecapeptides PPZPMs are composed of a beta-hydroxy fatty acid linked to a peptide part comprising 10 amino acids, where 8 of them are organized in a cyclic structure. PPZPMs differ from members of the Viscosin and Amphisin group by the number of amino acids forming the cyclic structure. The two main components, PPZPM-1a and PPZPM-2a, were investigated additionally by means of NMR spectroscopy.
Silicon nitride ceramic for all-ceramic dental restorations (2020)

Silicon nitride (Si<sub>3</sub>N<sub>4</sub>) is one of the promising ceramics for dental restoration due to providing significant benefits during the application. This study aimed to investigate the potential use of Si<sub>3</sub>N<sub>4</sub> for all-ceramic dental restorations by characterizing some critical properties as color shade, mechanical resistance, shear-bond strength and radiolucency. For our study, porous Si<sub>3</sub>N<sub>4</sub> ceramic was produced by partial sintering process with limited amounts of sintering additives and low temperature. A commercial ZrO<sub>2</sub> ceramic was prepared according to manufacturer's instructions and results were compared with Si<sub>3</sub>N<sub>4</sub>. Si<sub>3</sub>N<sub>4</sub> is an attractive ceramic for dental applications with good mechanical properties even in porous form, it has additional advantages over the conventional ceramics used as restorative material, such as, inherent antibacterial/anti-infective activity, radiolucency, and lower hardness. It is expected that Si<sub>3</sub>N<sub>4</sub> will become popular in dental applications as well.
Bacterial biosensors for the toxicity assessment of solid wastes (1996)

Two metal-lux fusions were constructed in Alcaligenes eutrophus by transposon Tn4431 mutagenesis. The resulting strains, named AE1239 (pMOL90::Tn4431) and AE1433 (pMOL30::Tn4431, pMOL28), were respectively emitting light in the presence of copper ions and in the presence of zinc, cadmium, cobalt, and lead ions. Both strains were freeze dried and used as microbial bioluminescent sensors for the evaluation of incinerator fly-ashes (IFA) and soils contaminated by heavy metals. Two detection protocols (with or without direct contact between the bacterial sensors and the IFA) were used to test different batches of IFA that were either not treated or treated in order to be used as recycled material. The bacterial light production measured with a luminometer in the presence of increasing concentrations of IFA was compared with the IFA metal concentration measured by inductively coupled plasma emission spectrometer. The same methodology was used to compare different soils samples from a sandy soil area severely contaminated by heavy metals. Both biosensors could successfully assess the bioavailability of heavy metals. This bioassay appeared to be very simple and rapid since no pretreatment of the samples was required. Those biosensors can either be used to predict the potential risk of the use of heavy metal-recycled materials in the environment or serve as a rapid screening tool for the efficacy of remediation practices used on contaminated soil. © 1996 by John Wiley & Sons, Inc.
Spontaneous and piezoelectric polarization effects in III–V nitride heterostructures (1999)

The role of spontaneous and piezoelectric polarization in III–V nitride heterostructures is investigated. Polarization effects and crystal polarity are reviewed in the context of nitride heterostructure materials and device design, and a detailed analysis of their influence in nitride heterostructure field-effect transistors is presented. The combined effects of spontaneous and piezoelectric polarization are found to account well for carrier concentrations observed in AlGaN/GaN transistor structures with low to moderate Al concentrations, while the data for higher Al concentrations are consistent with defect formation in the AlGaN barrier. Theoretical analysis suggests that incorporation of In into the barrier and/or channel layers can substantially increase polarization charge at the heterojunction interface. The use of polarization effects to engineer Schottky barrier structures with large enhancements in barrier height is also discussed, and electrical characteristics of transistors with conventional and polarization-enhanced Schottky barrier gates are presented. The polarization-enhanced barrier is found to yield a marked reduction in gate leakage current, but to have little effect on transistor breakdown voltage.
Blood flow acceleration in the carotid and brachial arteries of healthy volunteers: respective contributions of cardiac performance and local resistance (1996)

The influence of local resistance and cardiac performance on peripheral blood acceleration was investigated in 14 healthy male volunteers. Steady and pulsatile flow was studied in the brachial and in the common carotid arteries, ie, two territories that exhibit marked differences in resistive characteristics. Instantaneous blood velocity (V), mean blood velocity (Vm) and artery diameter (D) were evaluated at rest by an ultrasonic range-gated pulsed Doppler flowmeter using a double transducer probe, thus allowing the calculation of mean blood flow (Q). Mean local resistance (R) was obtained by dividing the mean arterial pressure by Q. The peak value of the local acceleration of the blood was obtained by computer-assisted calculation of the first derivative of instantaneous blood velocity (Gmax = +dV/dtmax). Peak aortic blood acceleration (GAo) was simultaneously measured from the suprasternal notch using a pulsed Doppler velocity meter. In the branchial and the common carotid arteries, Gmax was of a similar magnitude (551 +/- 30 and 555 +/- 44 cm/s2, respectively) despite major differences in the respective D, Vm, Q and R values. In neither artery was there a relationship between Gmax and either resting Q or R. At the brachial artery level, Gmax was positively related to GAo (r = 0.79, P = 0.0008). At the common carotid artery level, there was a weak, although non significant relationship between Gmax and GAo (P = 0.08). Our results indicate that the local acceleration of peripheral blood flow in the brachial artery is related rather to upstream central impulse than to downstream hemodynamics, and suggest some regional differences in the hemodynamic determinants of the local acceleration of peripheral blood flow.
Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics (2016)

We describe the identification of a novel, tumor-specific missense mutation in the active site of casein kinase 1α (CSNK1A1) using activity-based proteomics. Matched normal and tumor colon samples were analyzed using an ATP acyl phosphate probe in a kinase-targeted LC-MS2 platform. An anomaly in the active-site peptide from CSNK1A1 was observed in a tumor sample that was consistent with an altered catalytic aspartic acid. Expression and analysis of the suspected mutant verified the presence of asparagine in the probe-labeled, active-site peptide for CSNK1A1. Genomic sequencing of the colon tumor samples confirmed the presence of a missense mutation in the catalytic aspartic acid of CSNK1A1 (GAC→AAC). To our knowledge, the D163N mutation in CSNK1A1 is a newly defined mutation to the conserved, catalytic aspartic acid of a protein kinase and the first missense mutation identified using activity-based proteomics. The tumorigenic potential of this mutation remains to be determined.
Durable disease control with local treatment for oligoprogression of metastatic solid tumors treated with immune checkpoint blockade (2020)

Oligoprogression was observed in 4.1% of the entire cohort of patients on immune checkpoint inhibitors in this study and 15.7% of patients achieving at least stable disease. Among 16 patients experiencing oligoprogression, 15 received local therapy. At a median follow-up of 25.8 months, the median progression-free survival for patients with oligoprogression after local therapy was 15.4 months and zero patients had died. Oligoprogression occurs in a subset of patients after an initial response to CPI and local therapy to oligoprogressive sites may result in durable disease control.
Recent advances in melt electro writing for tissue engineering for 3D printing of microporous scaffolds for tissue engineering (2022)

Melt electro writing (MEW) is a high-resolution 3D printing technique that combines elements of electro-hydrodynamic fiber attraction and melts extrusion. The ability to precisely deposit micro- to nanometer strands of biocompatible polymers in a layer-by-layer fashion makes MEW a promising scaffold fabrication method for all kinds of tissue engineering applications. This review describes possibilities to optimize multi-parametric MEW processes for precise fiber deposition over multiple layers and prevent printing defects. Printing protocols for nonlinear scaffolds structures, concrete MEW scaffold pore geometries and printable biocompatible materials for MEW are introduced. The review discusses approaches to combining MEW with other fabrication techniques with the purpose to generate advanced scaffolds structures. The outlined MEW printer modifications enable customizable collector shapes or sacrificial materials for non-planar fiber deposition and nozzle adjustments allow redesigned fiber properties for specific applications. Altogether, MEW opens a new chapter of scaffold design by 3D printing.
GaAs charge-coupled devices (1978)

A Schottky-barrier-gate buried-channel GaAs CCD has been successfully demonstrated. A 10-cell (30 gates) three-phase device was operated at room temperature. The device employs a natural channel stop formed by the transfer gates extending from an n-type active region onto a semi-insulating GaAs substrate.
Evaluation of a technique of inducing hypertensive renal insufficiency in cats (2004)

Hypertensive renal insufficiency in group W was characterized by marked sustained systemic hypertension, decreased renal function, proteinuria, activation of the renin-angiotensin-aldosterone axis, and renal structural injury. Results support the hypothesis that marked systemic hypertension, activation of the renin-angiotensin-aldosterone axis, and proteinuria may damage the kidney of cats with preexisting renal insufficiency.
Effects of Clothianidin on Bombus impatiens (Hymenoptera: Apidae) Colony Health and Foraging Ability (2004)

We conducted laboratory experiments to investigate the lethal and sublethal effects of clothianidin on bumble bee, Bombus impatiens Cresson, colony health and foraging ability. Bumble bee colonies were exposed to 6 ppb clothianidin, representing the highest residue levels found in field studies on pollen, and a higher dose of 36 ppb clothianidin in pollen. Clothianidin did not effect pollen consumption, newly emerged worker weights, amount of brood or the number of workers, males, and queens at either dose. The foraging ability of worker bees tested on an artificial array of complex flowers also did not differ among treatments. These results suggest that clothianidin residues found in seed-treated canola and possibly other crops will not adversely affect the health of bumble bee colonies or the foraging ability of workers.
High-Speed Two-Photon Imaging (2013)

The small size of neuronal dendrites and spines combined with the high speed of neurophysiological signals, such as transients in membrane potential or ion concentration, necessitates that any functional study of these structures uses recording methods with both high spatial and high temporal resolutions. In this regard, conventional two-photon microscopy, in combination with fluorescent indicators sensitive to physiological parameters, has proved to be only a partial solution by providing near-diffraction-limited spatial resolution even when imaging structures deep inside light-scattering tissue. This is because the relatively slow beam-scanning methods used in most conventional two-photon microscopes severely limit the extent to which functional data can be recorded. Here, we detail developments to create high-speed two-photon imaging systems that overcome this limitation and discuss important considerations that must be taken into account when attempting to construct such systems.
The cortical excitability profile of temporal lobe epilepsy (2013)

Changes in cortical excitability seen in patients with TLE are influenced by the course of the disease. The alterations that occur due to epilepsy are closely related to course of illness and degree/timing of seizure control. Successful management leads to resolution of this cortical hyperexcitability in a similar fashion regardless of method: medication (intact generator, but modulated by drugs) or surgery (generator removed).
An Architecture and Business Model for Making Software Agents Commercially Viable (2005)

While several research projects have been proposed to use software agents to deal with information overload, their results are not applicable in the existing Web infrastructure mainly because no Web sites are agent-enabled. There are two main reasons why Web site operators are not willing to let agents run on them: (1) security issues; (2) many commercial Web sites make money from advertisement, and if agents are going to do the work then who is going to see the ads? In this paper, we discuss the design of an architecture that addresses the above issues. What is interesting about this architecture is that it enables businesses to form beneficial partnerships (e.g. between content providers and Internet Services Providers (ISPs) or even cellular network operators). A proof-of-concept implementation using Java RMI for this architecture has been carried out as part of the Havana mobile agent platform. This platform can be easily integrated into existing Web sites, and accessed from any device.
The type II PIPkins (PtdIns5P 4-kinases): enzymes in search of a function? (1999)

Conference Article| August 01 1999 The type II PIPkins (PtdIns5P 4-kinases): enzymes in search of a function? K. A. Hinchliffe; K. A. Hinchliffe 1 *Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, U.K. 1To whom correspondence should be addressed Search for other works by this author on: This Site PubMed Google Scholar A. Ciruela; A. Ciruela *Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, U.K. Search for other works by this author on: This Site PubMed Google Scholar J. A. Morris; J. A. Morris *Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, U.K. Search for other works by this author on: This Site PubMed Google Scholar N. Divecha; N. Divecha †The Netherlands Cancer Institute, Antoni van Leeuwenhoek-huis, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar R. F. Irvine R. F. Irvine *Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1999) 27 (4): 657–661. https://doi.org/10.1042/bst0270657 Article history Received: March 05 1999 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation K. A. Hinchliffe, A. Ciruela, J. A. Morris, N. Divecha, R. F. Irvine; The type II PIPkins (PtdIns5P 4-kinases): enzymes in search of a function?. Biochem Soc Trans 1 August 1999; 27 (4): 657–661. doi: https://doi.org/10.1042/bst0270657 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: PIPkin, PtdInsP kinase, GFP, green fluorescent protein © 1999 Biochemical Society1999 Article PDF first page preview Close Modal You do not currently have access to this content.