gebhart/patrepeval huggingface dataset:
New Natural Products from the Sponge-Derived Fungus Aspergillus niger. (2005)

ADVERTISEMENT RETURN TO ISSUEPREVErratumORIGINAL ARTICLEThis notice is a correctionNew Natural Products from the Sponge-Derived Fungus Aspergillus niger.J. Hiort, K. Maksimenka, M. Reichert, S. Perović-Ottstadt, W. H. Lin, V. Wray, K. Steube, K. Schaumann, H. Weber, P. Proksch, R. Ebel, W. E. G. Müller, and G. BringmannCite this: J. Nat. Prod. 2005, 68, 12, 1821Publication Date (Web):November 24, 2005Publication History Published online24 November 2005Published inissue 1 December 2005https://doi.org/10.1021/np058103oCopyright © 2005 American Chemical Society and American Society of PharmacognosyRequest reuse permissions This publication is free to access through this site. Learn MoreArticle Views1112Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (35 KB) Get e-Alertsclose Get e-Alerts
Diffeomorphic Metric Mapping of High Angular Resolution Diffusion Imaging Based on Riemannian Structure of Orientation Distribution Functions (2011)

In this paper, we propose a novel large deformation diffeomorphic registration algorithm to align high angular resolution diffusion images (HARDI) characterized by orientation distribution functions (ODFs). Our proposed algorithm seeks an optimal diffeomorphism of large deformation between two ODF fields in a spatial volume domain and at the same time, locally reorients an ODF in a manner such that it remains consistent with the surrounding anatomical structure. To this end, we first review the Riemannian manifold of ODFs. We then define the reorientation of an ODF when an affine transformation is applied and subsequently, define the diffeomorphic group action to be applied on the ODF based on this reorientation. We incorporate the Riemannian metric of ODFs for quantifying the similarity of two HARDI images into a variational problem defined under the large deformation diffeomorphic metric mapping framework. We finally derive the gradient of the cost function in both Riemannian spaces of diffeomorphisms and the ODFs, and present its numerical implementation. Both synthetic and real brain HARDI data are used to illustrate the performance of our registration algorithm.
The preparation and purification of cytidine 2′:3′-phosphate (1960)

Research Article| February 01 1960 The preparation and purification of cytidine 2′:3′-phosphate E. M. Crook; E. M. Crook 1Department of Biochemistry, University College London, Gower Street, London, W.C. 1 Search for other works by this author on: This Site PubMed Google Scholar A P Mathias; A P Mathias 1Department of Biochemistry, University College London, Gower Street, London, W.C. 1 Search for other works by this author on: This Site PubMed Google Scholar B. R. Rabin B. R. Rabin 1Department of Biochemistry, University College London, Gower Street, London, W.C. 1 Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1960) 74 (2): 230–233. https://doi.org/10.1042/bj0740230 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation E. M. Crook, A P Mathias, B. R. Rabin; The preparation and purification of cytidine 2′:3′-phosphate. Biochem J 1 February 1960; 74 (2): 230–233. doi: https://doi.org/10.1042/bj0740230 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1960 CAMBRIDGE UNIVERSITY PRESS1960 Article PDF first page preview Close Modal You do not currently have access to this content.
Conformational and Immunogenicity Studies of the Shigella flexneri Serogroup 6 O-Antigen: The Effect of O-Acetylation (2021)

The pathogenic bacterium <i>Shigella</i> is a leading cause of diarrheal disease and mortality, disproportionately affecting young children in low-income countries. The increasing prevalence of antibiotic resistance in <i>Shigella</i> necessitates an effective vaccine, for which the bacterial lipopolysaccharide O-antigen is the primary target. <i>S. flexneri</i> serotype 6 has been proposed as a multivalent vaccine component to ensure broad protection against <i>Shigella</i>. We have previously explored the conformations of <i>S. flexneri</i> O-antigens from serogroups Y, 2, 3, and 5 that share a common saccharide backbone (serotype Y). Here we consider serogroup 6, which is of particular interest because of an altered backbone repeat unit with non-stoichiometric O-acetylation, the antigenic and immunogenic importance of which have yet to be established. Our simulations show significant conformational changes in serogroup 6 relative to the serotype Y backbone. We further find that O-acetylation has little effect on conformation and hence may not be essential for the antigenicity of serotype 6. This is corroborated by an in vivo study in mice, using Generalized Modules for Membrane Antigens (GMMA) as O-antigen delivery systems, that shows that O-acetylation does not have an impact on the immune response elicited by the <i>S. flexneri</i> serotype 6 O-antigen.
Transmission of the Mycopathogen,Hirsutellaspp., to Nymphs and Adults of the Glassy-Winged Sharpshooter,HomalodiscaVitripennis(=Coagulata), in the Greenhouse (2011)

For the first time, transmission of Hirsutella from mycosed, sporulating H. vitripennis to healthy conspecifics was demonstrated. In addition, methods were established to amplify infectious material in vivo for potential inoculative release.
Molecular shape similarity between cyclic imides and protoporphyrinogen IX (1999)

Comparisons using computational techniques, of shapes and bond angles of compounds which act as protoporphyrinogen IX oxidase (protox) inhibitors indicate structural similarities between the different compounds. Experiments show that cyclic imides and diphenyl ethers both inhibit protox, but have different binding sites. © 1999 Society of Chemical Industry
21.3 A 200nA single-inductor dual-input-triple-output (DITO) converter with two-stage charging and process-limit cold-start voltage for photovoltaic and thermoelectric energy harvesting (2016)

Energy harvesting has been considered to be a good solution to power many IoE applications [1-3]. Some applications require regulated supply voltage, while on the other hand, any extra energy should be stored in the storage element, such as a rechargeable battery, to maximize the total system efficiency. As the power delivery density is small in the energy-harvesting application, using a single inductor to transfer the power from the harvester to multiple outputs is achievable and efficient. The DITO architecture has three outputs as shown in Fig. 21.3.1: one is the regulated voltage output REG_OUT, the second is the unregulated voltage output SYS and the third is the rechargeable battery BAT. Due to the unpredictable environment conditions, the harvester could be in an environment without a corresponding energy source available for a long time. In order to keep the system operation without the harvester input VIN, the backup battery at BACK_UP is necessary, which would be the second power input of the system. The control scheme should make sure the backup battery only delivers power to the system when necessary in order not to waste any energy in the backup battery.
A BCU method for direct analysis of power system transient stability (1994)

A boundary of stability region based controlling unstable equilibrium point method (BCU method) for direct analysis of power system transient stability is presented. Features distinguishing the BCU method from the existing direct methods are that it consistently finds the exact controlling unstable equilibrium point (UEP) relative to a fault-on trajectory and that it has a sound theoretical basis. Moreover, the BCU method appears to be fast. This method is based on the relationship between the boundary of stability region of a power system and that of a reduced system. The BCU method finds the controlling UEP of the original system via a reduced system whose controlling UEP is easier and cheaper to compute. Effective numerical schemes to speed up the presented method are also proposed. This method has been tested on several power systems with very promising results. Simulation results on a 50 generator, 145 bus system are presented along with a comparison between the results obtained using the BCU method and another existing method.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Nonreacting turbulent mixing flows: a literature survey and data base (1986)

The objective of this report is to provide a comprehensive review of available data on turbulent nonreacting flows. This review is limited to parabolic, stationary shear flows with well defined boundary conditions; these flows have many of the characteristics found in combustion devices and are typical of laboratory flames for which model evaluation data are most likely to be available. This report is an outgrowth of a more extensive study conducted under the direction of the Air Force Office of Scientific Research. A bound volume containing the results of that study will be available in the near future. Our purpose in compiling the data presented here is to provide a more comprehensive tabulation of nonreacting flow measurements than was possible to include in the Air Force report. 97 refs., 23 figs., 184 tabs.
Photoinitiated crosslinking of low density polyethylene. III: Degradation and stabilization of photocrosslinked polyethylene (1994)

Abstract Electron spectroscopy (ESCA) and reflectance infrared spectroscopy (ATR) were used to measure surface oxidation of photocrosslinked polyethylene. The deterioration of bulk properties during an artificial weathering test was also measured. It was found that the UV‐irradiation during crosslinking process decreases the stability of the material considerably. Three kinds of antioxidants and photostabilizers (hindered phenols, hindered amines, and organic sulfides) which have no absorption in the UV region of 300 to 400 nm were added before crosslinking to improve the stability of the crosslinked material. Neither the rate nor the degree of photocrosslinking at different depths of the sample were affected significantly by these additives. It was found possible to prevent the decrease in stability due to the photocrosslinking by using small amounts of a stabilizer, e.g. 0.05% Tinuvin 770 (hindered amine).
Identification of molecular markers for Sw-5 gene of tomato spotted wilt virus resistance (2011)

Tomato spotted wilt virus (TSWV) is one of the most destructive viral diseases that threaten worldwide tomato (Solanuum lycopersicum L. syn Lycopersicon esculentum Mill.) production. Use of host resistance appears to be the best way to control the disease. Marker assisted selection (MAS) has become very important and useful in the selection of TSWV resistance genes. The objective of this research was to identify Sw-5 gene-specific PCR-based molecular markers and gene-derived single nucleotide polymorphism (SNP) markers for MAS in tomato breeding. A gene-specific PCR-based marker and two gene-derived SNP markers specific for TSWV resistance Sw5-b allele were identified and validated in different tomato germplasm. It is expected that the present findings will be helpful in advancing the MAS for TSWV resistance in tomato.
Polymorphism of VDR Gene and the Sensitivity of Human Leukemia and Lymphoma Cells to Active Forms of Vitamin D (2022)

The active forms of vitamin D<sub>3</sub> (calcitriol and tacalcitol) coupled to the vitamin D receptor (VDR) are known to exhibit anti-cancer properties. However, not all cancer cells are sensitive to the active forms of vitamin D<sub>3</sub> and its analogs. The study aimed to determine whether polymorphism of VDR is responsible for the sensitivity of human leukemia and lymphoma cells to calcitriol and tacalcitol. The impact of calcitriol and tacalcitol on the proliferation and morphology of nine different leukemia and lymphoma cell lines was determined. Only MV-4-11, Thp-1, and HL-60 cell lines sensitive to proliferation inhibition by calcitriol and tacalcitol showed morphology changes. Subsequently, the levels of the VDR and 1,25D<sub>3</sub>-MARRS proteins of calcitriol and tacalcitol binding receptors and the VDR receptor polymorphism in human leukemia and lymphoma cells were ascertained. Contrary to the current understanding, higher levels of VDR are not responsible for the greater sensitivity of cells to calcitriol and tacalcitol. Importantly, we first showed that sensitivity to calcitriol and tacalcitol in leukemias and lymphomas could be determined by the VDR polymorphism. The <i>Fok</i>I polymorphism and the presence of the "bat" haplotype were observed only in the sensitive cells.
Correlation between the Width of the Glass Transition Region and the Temperature Dependence of the Viscosity of High‐Tg Glasses (1993)

A correlation exists between the width of the glass transition region measured using DTA or DSC during heating and the activation enthalpy Δ H η * for the shear viscosity of high‐Tginorganic glasses. This is demonstrated by the constancy of a dimensionless parameter C = (Δ H η * / R )(1/Tg – 1/Tg′), where Tg and Tg′ are temperatures marking the extrapolated onset and finish of the transition region on the DTA or DSC trace. The logarithm of the shear viscosity at Tg, log η (Tg), is also approximately constant for high‐Tg glasses. Using the universal values of C and log η (Tg), fairly reliable estimates of shear viscosities from the transition range through the working range can be made from the Tg and Tg′ values obtained using DTA or DSC.
Isolation of Stem and Precursor Cells from Fetal Tissue (2003)

Generation of neurons, astrocytes, and oligodendrocytes in the nervous system involves a sequential process of differentiation. Initially, multipotent stem cells generate more restricted precursor cells, which go through additional stages of differentiation to generate fully differentiated progeny (1). Precursor cells at each stage of differentiation can be distinguished from each other on the basis of cytokine dependence, functional properties, and antigen expression. Using markers to antigens expressed on the cell surface, live multipotent stem cells, intermediate precursor cells, and differentiated cells can be isolated at various stages of development.
Supplementary Movie 2 from Cell Adhesion Molecule L1 Disrupts E-Cadherin-Containing Adherens Junctions and Increases Scattering and Motility of MCF7 Breast Carcinoma Cells (2023)

Supplementary Movie 2 from Cell Adhesion Molecule L1 Disrupts E-Cadherin-Containing Adherens Junctions and Increases Scattering and Motility of MCF7 Breast Carcinoma Cells
Experimental evaluation of bilayered human collagen as a dural substitute (1993)

Many substances have been tried as possible dural substitutes, and different tissues and materials have been evaluated for use in dural repair; however, an entirely satisfactory solution still remains to be found. The authors report an experimental study involving the closure of dural defects in dogs with a new biomaterial, resorbable bilayered human placental collagen, using two types of collagen material. These include a collagen bilayered dural substitute made of oxidized type III + I collagen layer covered by a type IV oxidized collagen film (collagen dural substitute I) and a collagen bilayered dural substitute made of oxidized type III + I collagen layer covered by a type III + I collagen film (collagen dural substitute II). Macroscopic and histological examination, performed over a period of between 15 and 180 days after implantation, showed the resorption of collagen graft and formation of a neomembrane that looked like a neodura within 3 months. No infection and no cerebrospinal fluid fistulae were noticed. Nevertheless, one slight cerebromembranous adhesion was found with collagen dural substitute II. The authors suggest that human resorbable collagen biomaterial could be used as a very satisfactory dural substitute.
Wrinkling of Extruded Sheets (1970)

Material extruded in sheet form sometimes wrinkles to accommodate the expansion of the material. An approximate analysis is made of the phenomenon in order to establish a wrinkling criterion. If wrinkling does occur, the analysis gives the wrinkling frequency.
Comparison of Scoring Approaches for the NEI VFQ-25 in Low Vision (2010)

Although standard scores and Rasch scores are highly correlated, Rasch analysis has the advantages of eliminating floor and ceiling effects and producing interval-scaled data. The Massof algorithm for approximation of the Rasch person measure performed well in this group of low-vision patients. The validity of the subscales VFQ-25 should be reconsidered.
Palmitate and pyruvate carbon flux in response to choline and methionine in bovine neonatal hepatocytes (2020)

Choline and methionine may serve unique functions to alter hepatic energy metabolism. Our objective was to trace carbon flux through pathways of oxidation and glucose metabolism in bovine hepatocytes exposed to increasing concentrations of choline chloride (CC) and D,L-methionine (DLM). Primary hepatocytes were isolated from 4 Holstein calves and maintained for 24 h before treatment with CC (0, 10, 100, 1000 μmol/L) and DLM (0, 100, 300 μmol/L) in a factorial design. After 21 h, [1-<sup>14</sup>C]C16:0 or [2-<sup>14</sup>C]pyruvate was added to measure complete and incomplete oxidation, and cellular glycogen. Reactive oxygen species (ROS), cellular triglyceride (TG), and glucose and ß-hydroxybutyrate (BHB) export were quantified. Exported very-low density lipoprotein particles were isolated for untargeted lipidomics and to quantify TG. Interactions between CC and DLM, and contrasts for CC (0 vs. [10, 100, 1000 μmol/L] and linear and quadratic contrast 10, 100, 1000 μmol/L) and DLM (0 vs. [100, 300 μmol/L] and 100 vs. 300 μmol/L) were evaluated. Presence of CC increased complete oxidation of [1-<sup>14</sup>C]C16:0 and decreased BHB export. Glucose export was decreased, but cellular glycogen was increased by the presence of CC and increasing CC. Presence of CC decreased ROS and marginally decreased cellular TG. No interactions between CC and DLM were detected for these outcomes. These data suggest a hepato-protective role for CC to limit ROS and cellular TG accumulation, and to alter hepatic energy metabolism to support complete oxidation of FA and glycogen storage regardless of Met supply.
Translational Medicine Policy Issues in Infectious Disease (2010)

The European Academies Science Advisory Council has published a series of reports on infectious disease policy issues, analyzing priorities for building the science base as part of public health strategy. Among current challenges facing the European Union are the needs to tackle antibiotic resistance, promote vaccine innovation, prepare for the emergence of novel zoonoses, and integrate research approaches to human and animal health. The scientific community must help public policy-makers to address the organization, balance, and sustainability of research funding and infrastructure; encourage the creation of a more supportive regulatory environment for translational medicine; and evaluate new models for public-private partnership to facilitate innovation.
El legado ético de Santiago Ramón y Cajal (2002)

The application of triazole fungicides is a common practice in the cultivation of carrot (Daucus carota L.) plants. It is there for seems important to test the changes that are occurring in this food crop under triazoles, the non-traditional plant growth regulators, treatments in order to identify the extent to which it tolerate the fungicide application and thereby make it an economical food crop. A field experiment was conducted to find out the effects of two triazole fungicides (hexaconazole (HEX) and paclobutrazol (PBZ) at 20mg l(-1) plant(-1)) on the biomass, yield, electrolyte leakage, lipid peroxidation and antioxidant potential of carrot. The treatments were given to plants on 15, 30 and 45 days after sowing (DAS). The plants were uprooted for analyses of growth and biochemical parameters on 60 DAS. It was found that both HEX and PBZ have significant effects on the growth and biochemical parameters of this plant. Among the triazoles used, PBZ performed best in terms of anthocyanin, protein, amino acid, proline, starch and sugar, contents whereas HEX enhanced carotenoids, fresh weight, dry weight and biomass. There was no significant variation in chlorophyll ('a' and 'b') contents between the two triazole treated plants, but HEX and PBZ proved best when compared to untreated control plants. HEX and PBZ increased alpha- and beta-amylases enzymes activities to a significant level. Out of these two triazoles, PBZ performed best in increasing the starch hydrolyzing enzymes activities. The non-enzymatic antioxidant, reduced glutathione (GSH) and antioxidant enzyme ascorbate peroxidase (APX) were increased under fungicide applications. The data suggests that, the application of triazole fungicides may be a useful tool to increase the tuber quality as well as quantity in carrot plants, apart from their fungicidal properties.
Longitudinal Increases in Knee Abduction Moments in Females during Adolescent Growth (2015)

Increases in peak KAM during and after PHV seem to coincide with increased risk of ACL injury in females. KAM peaked in females at PHV. Tracking longitudinal increases in peak KAM may be useful for the identification of females at increased risk of ACL injury.
Sensory Coding with Dynamically Competitive Networks (1999)

Studies of insect olfactory processing indicate that odors are represented by rich spatio-temporal patterns of neural activity. These patterns are very difficult to predict a priori, yet they are stimulus specific and reliable upon repeated stimulation with the same input. We formulate here a theoretical framework in which we can interpret these experimental results. We propose a paradigm of ``dynamic competition'' in which inputs (odors) are represented by internally competing neural assemblies. Each pattern is the result of dynamical motion within the network and does not involve a ``winner'' among competing possibilities. The model produces spatio-temporal patterns with strong resemblance to those observed experimentally and possesses many of the general features one desires for pattern classifiers: large information capacity, reliability, specific responses to specific inputs, and reduced sensitivity to initial conditions or influence of noise. This form of neural processing may thus describe the organizational principles of neural information processing in sensory systems and go well beyond the observations on insect olfactory processing which motivated its development.