gebhart/patrepeval huggingface dataset:
Rhabdoid Tumor Predisposition Syndrome: From Clinical Suspicion to General Management (2021)

Rhabdoid tumors are rare aggressive malignancies in infants and young children with a poor prognosis. The most common anatomic localizations are the central nervous system, the kidneys, and other soft tissues. Rhabdoid tumors share germline and somatic mutations in <i>SMARCB1</i> or, more rarely, <i>SMARCA4</i>, members of the SWI/SNF chromatin-remodeling complex. Rhabdoid tumor predisposition syndrome (RTPS) is a condition characterized by a high risk of developing rhabdoid tumors, among other features. RTPS1 is characterized by pathogenic variants in the <i>SMARCB1</i> gene, while RTPS2 has variants in <i>SMARCA4</i>. Interestingly, germline variants of <i>SMARCB1</i> and <i>SMARCA4</i> have been identified also in patients with Coffin-Siris syndrome. Children with RTPS typically present with tumors before 1 year of age and in a high percentage of cases develop synchronous or multifocal tumors with aggressive clinical features. The diagnosis of RTPS should be considered in patients with rhabdoid tumors, especially if they have multiple primary tumors and/or in individuals with a family history. Because germline mutations result in an increased risk of carriers developing rhabdoid tumors, genetic counseling, and surveillance for all family members with this condition is recommended.
Nonpharmacologic Approaches to the Treatment of Atrial Fibrillation and Atrial Flutter (1995)

The high prevalence of atrial fibrillation, the associated morbidity and mortality, the absence of safe and effective drug therapy, and an increased understanding of the pathophysiologic basis of atrial fibrillation and flutter have collectively led to the development of novel nonpharmacologic treatments for the management of these arrhythmias, including the CORRIDOR and MAZE surgical procedures, catheter-based ablation and modification of AV conduction, catheter-based ablation of atrial flutter and fibrillation, and internal atrial defibrillation. These surgical and catheter-based techniques offer potentially curative therapy while sparing the long-term risk of antiarrhythmic drug therapy. For patients with typical atrial flutter, catheter ablation affords to cure rate in excess of 70%. As technological innovations further facilitate identification and ablation of the critical isthmus in the floor of the right atrium, success rates should improve substantially. For patients with atrial fibrillation, AV junction ablation with implantation of a rate-responsive ventricular pacemaker should be considered palliative therapy, as should modification of AV junction conduction. The MAZE procedure offers very high cure rates, but because it currently involves open heart surgery, patient selection is critical. Catheter-based procedures emulating aspects of the MAZE procedure may one day offer cure rates comparable to those of the surgery itself, but additional research and technological development are necessary to further define and refine the minimal effective procedure, and then to facilitate the placement of contiguous, full-thickness lesions in precise three-dimensional configurations. In the interim, the implantable automatic atrial defibrillator may offer a means for rapidly restoring sinus rhythm without the risks of long-term antiarrhythmic drug therapy.
ChemInform Abstract: Microwave Synthesis (2013)

Abstract Review: 35 refs.
Isoform-Specific Ras Activation and Oncogene Dependence during MYC- and Wnt-Induced Mammary Tumorigenesis (2006)

We have previously shown that c-MYC-induced mammary tumorigenesis in mice proceeds via a preferred secondary pathway involving spontaneous activating mutations in Kras2 (C. M. D'Cruz, E. J. Gunther, R. B. Boxer, J. L. Hartman, L. Sintasath, S. E. Moody, J. D. Cox, S. I. Ha, G. K. Belka, A. Golant, R. D. Cardiff, and L. A. Chodosh, Nat. Med. 7:235-239, 2001). In contrast, we now demonstrate that Wnt1-induced mammary tumorigenesis proceeds via a pathway that preferentially activates Hras1. In addition, we find that expression of oncogenic forms of Kras2 and Hras1 from their endogenous promoters has markedly different consequences for the progression of tumors to oncogene independence. Spontaneous activating Kras2 mutations occurring in either MYC- or Wnt1-induced tumors were strongly associated with oncogene-independent tumor growth following MYC or Wnt1 downregulation. In contrast, Hras1-mutant Wnt1-induced tumors consistently remained oncogene dependent. Additionally, Kras2-mutant tumors exhibited substantially higher levels of ras-GTP, phospho-Erk1/2, and phospho-Mek1/2 compared to Hras1-mutant tumors, suggesting the involvement of the ras/mitogen-activated protein kinase (MAPK) pathway in the acquisition of oncogene independence. Consistent with this, by use of carcinogen-induced ras mutations as well as knock-in mice harboring a latent activated Kras2 allele, we demonstrate that Kras2 activation strongly synergizes with both c-MYC and Wnt1 in mammary tumorigenesis and promotes the progression of tumors to oncogene independence. Together, our findings support a model for tumorigenesis in which c-MYC and Wnt1 select for the outgrowth of cells harboring mutations in specific ras isoforms and that these secondary mutations, in turn, determine the extent of ras/MAPK pathway activation and the potential for oncogene-independent growth.
The Synthesis of 5,11,17‐Trihalotetracyclo [13.3.1.13,7.19,13]henicosa‐1 (19),3,5,7 (20),9,11,13 (21), 15,17‐nonaene‐19,20,21‐triols and 5,11,17‐trihalo‐19,20,21‐trihydroxytetracyclo [13.3.1.13,7. 19,13]henicosa‐1 (19),3,5,7 (20),9,11,13(21), 15,17‐nonaene‐8,14‐dione [1]. Cyclo‐derivatives of Phloroglucide Analogues (1982)

Abstract The synthesis of the title compounds ( 1 and 3 ) is described. Some of the compounds prepared were found to be active against a number of pathogenic microorganisms in vitro. Structure‐activity relationship is briefly discussed.
Effects of Coupled Tumor Specific Antigens (CTSA) on the Growth of Transplanted Tumors in C<sub>3</sub>H/HEJ Mice (1976)

The effects of coupled tumor specific antigens (CTSA) on the suppression of tumor growth in inbred mice were investigated. Seventy six week old C3H/HEJ female mice were used in the experiment. They were divided into seven groups; each group consisted of ten mice, and each group received a different treatment. The treatments for the different groups were: Human gamma globulin coupled with tumor specific antigens and emulsified in Freund's complete adjuvant (group I); Tumor specific antigens emulsified in Freund's complete adjuvant (group II); Freund's complete adjuvant (group III); Tumor specific antigens (group IV); Human gamma globulin (group V); Groups VI and VII were untreated. Animals in groups (I to V) were given two injections per week for two weeks prior to the transplantation of tumor tissue. They were subsequently given sixteen more injections during an eight week period. The sixth group was transplanted with tumor tissue and the seventh group was neither treated nor transplanted with tumor. The proliferation of the tumor tissue in the different animals was monitored by computing tumor volume at weekly intervals. The results showed that animals in group I developed a state of immune resistance against the transplanted tumor. At the conclusion of the experiment, the average tumor volume in this group was six times smaller than the average volume in the untreated group and twelve times smaller than the average volume in the group treated with Freund's complete adjuvant. Varying degrees of suppression were also noted in the other treated groups.
Codeposition generation of BeCl in an argon matrix at 12 K: An ESR investigation (1981)

The molecular radical BeCl has been produced by the codeposition of beryllium atoms and chlorine in an argon matrix at 12 K. An ESR investigation yields the following magnetic parameters: g∥ = 2.001 (1), g⊥ = 1.998 (1), A∥(Be) = 282 (2) MHz, A⊥(Be) = 268 (2) MHz, ‖A∥‖(35Cl) = 53 (2) MHz, and ‖A⊥‖(35Cl) = 24 (2) MHz. Spin densities obtained from the ESR results are compared with ab initio calculations. The calculations yield a dipole moment of 1.0 D for BeCl. These results for BeCl are compared with BeF, BeOH, and BeH. BeCl, unlike BeF, does not exhibit rotational behavior in an argon matrix.
Control of the radio-frequency wave form at the chuck of an industrial oxide-etch reactor (2000)

Radio frequency (rf) power is commonly applied to the chuck of a high-density plasma reactor in order to extract ions and to control the energy of the ions used for the fabrication of microelectronic devices. In many cases, the temporal shape of the rf wave form largely determines the shape of the spectrum of those extracted ions, thereby strongly affecting feature evolution. Using auxiliary rf circuits, we successfully made major changes to the rf-potential wave form at the chuck of an Applied Materials 5300 HDP Omega reactor without affecting the normal functioning of the reactor’s control systems. This work established the practical feasibility of techniques for modifying the ion energy distribution functions of industrial reactors.
Raw sequencing data for "Chemical evolution of Rhinovirus identifies capsid-destabilizing mutations driving low pH-independent genome uncoating" (2021)

Here, we provide the raw sequencing data on the manuscript with the title: "Chemical evolution of Rhinovirus identifies capsid-destabilizing mutations driving low pH-independent genome uncoating". Files with the prefix 'orig_' are the sequenced 'P10' viruses from Fig. 1B, in which we detected G2274T and A2526G. The other .fastq.gz files are pertaining to Fig. 5, where the number denotes the lineage id. The file: 'p16-11-genomic-fragment.fasta' was used as a reference.
Prognostic value of microRNA expression levels in pancreatic adenocarcinoma: a review of the literature (2017)

There is growing evidence that miRNA expression profiles have the potential to provide tumor-specific prognostic information to assist clinicians in more appropriately selecting patients for adjuvant therapy. These molecules are often aberrantly expressed and exhibit oncogenic and/or tumor suppressor functions in PDAC. Additional efforts to develop prognostic and predictive molecular signatures, and further elucidate miRNA mechanisms of action, are warranted.
Guerre scolaire ou guerre de religion?: réflexions sur deux épisodes de l'histoire politique belge contemporaine (1998)

info:eu-repo/semantics/nonPublished
Hierarchical Charge Control of Large Populations of EVs (2015)

Cooperation between the controllable load, such as electrical vehicles (EVs) and the generation, provides the power system new operating strategies. A novel hierarchical charge control framework is proposed based on the Benders decomposition for large populations of EVs. The grid, unit, and accurate EV constraints can be considered. On the upper level, the cooperative dispatch scheme between the generation and the EV aggregators is obtained. On the lower level, the feasibility of the scheme is checked with EV constraints considered. The levels are coordinated by the Benders cuts. In addition, the distributed approximate Benders cuts is also proposed, which helps to protect user privacy and a three-level framework is developed based on the decentralized control. The case studies on IEEE Reliability Test System have verified the proposed framework and method is valid and feasible. The charge control based on it can minimize the grid operation cost and improve the unit operating efficiency.
Constitutive and Variable Regions of Z-disk Titin/Connectin in Myofibril Formation: A Dominant-negative Screen. (1997)

The giant muscle protein titin (connectin) is assumed to play a crucial role in the control of Z-disk assembly. Analysis of the Z-disk region of titin/connectin revealed a novel 45 residue repeat that is spliced in variable copy numbers. The repeat region is coexpressed in normal human myocardium in size variants corresponding to between 5 and 7 repeats. Smaller isoforms can be detected in muscles with thinner Z-disks like M. psoas. Sequence analysis of chicken breast muscle titin/connectin reveals that in this tissue, where Z-disks are thin, only two Z-repeats are expressed. The greatly variable thickness of Z-disks is therefore correlated to a region of variable length in titin/connectin, constructed from a novel protein building block. Transfection experiments in myogenic cell lines demonstrate that overexpression of the entire integral Z-disk region of titin leads to a disruption of sarcomere assembly. The differentially expressed titin/connectin regions, however, show no dominant-negative effects on myofibril assembly and are not targeted to Z-disks. This supports the idea that the Z-repeat region of titin/connectin is responsible for the control Z-disk thickness as an element of highly variable length, due to extensive differential splicing.
Revisiting thalidomide: fighting with caution against idiopathicpulmonary fibrosis (2012)

Thalidomide is an infamous drug whose use by pregnant women in the middle of last century tragically resulted in serious birth defects. However, as a result of its potent immunomodulatory, anti-inflammatory and antiangiogenic properties, thalidomide may be a potential therapy in many diseases. In recent years, thalidomide has been used effectively to treat various malignancies, including multiple myeloma, myelodysplastic syndromes, renal cell cancer, glioblastoma multiforme and prostate cancer. In addition, thalidomide has also proven effective against other immune-related diseases, including erythema nodosum leprosum and sarcoidosis. Idiopathic pulmonary fibrosis (IPF) is a deadly fibrotic disease with no effective treatment options. However, there is data to suggest that thalidomide may be useful in treating the chronic, disabling cough that accompanies IPF. It remains to be seen whether the immunomodulatory and antiangiogenic properties of thalidomide will also make it a potential therapy against the clinical progression of IPF.
Low Power Load Interface For Vibrational Energy MEMS harvesters (2016)

International audience
New approach of fixation possibilities investigation for snake robot in the pipe (2015)

The research field of the snake robots provides a large scale of new information. The snake robots locomotion in pipes represents one of many complicated problems attracting the attention only in recent time period. During this study an experimental environment was designed corresponding to the pipe of U shaped cross section. This article describes a new innovative kinematic structure enabling both rotary and translational movements of links of a snake robot. Combination of these two robot constrains in constructions provides new possibilities of locomotion in a confined space. The main work contribution consists in the analysis of geometric configuration of links in static fixation according to their displacements and required actuators electric power. In the experiment with physical model the method of digital image correlation was used because of the possibilities to take the movement of high dynamic range. Contribution of this experiment furnishes new information and new approach in solving the existing problem.
[Mechanisms of HIV replication and anti-HIV drug action]. (2010)

HIV is the causative agent for AIDS. This replicates in CD4+ T cells and macrophages, and produces the infectious particles from multiple intracellular events. Chemicals against these intracellular events, especially reverse transcription, integration, and processing, have been successfully generated and HIV replication and disease progression can be effectively suppressed by combination administration of the chemicals. To understand anti-HIV drugs, we firstly illustrate the life cycles of HIV replication and then, summarize the enzymatic mechanisms of reverse transcriptase, integrase, and protease, and the inhibitor actions.
Generalized Bayesian speckle tracking applied to strain and ARFI displacements (2011)

Biased estimators with mean square error surpassing that described by the Cramer-Rao lower bound are implemented using Bayes' Theorem. In order to use Bayes' Theorem a new likelihood function was developed specifically for the ultrasound time-delay estimation problem. Results are shown for bulk, step, compression, and ARFI displacements.
Monocular feature-based periodic motion estimation for surgical guidance (2013)

In this paper, we present a novel approach for mapping periodically moving visual features with a monocular camera. Our target application is the estimation of moving surfaces during minimally invasive surgery for the purpose of aiding in the guidance of surgical tools. Our approach uses a bank of Kalman filters to estimate FFT parameters that encode the periodic motion of visually detected features. To ensure convergent estimation for this highly nonlinear problem, we have developed an iterative update procedure that treats the Kalman filter measurement update step as an optimization problem. Unlike existing solutions that rely on stereo vision, our approach estimates periodic motion with a single moving camera. With an experiment involving a beating heart phantom, we have shown that our approach is able to successfully estimate the periodic motion of visual features.
Mechanism of the antiviral action of 1-beta-D-arabinofuranosylcytosine on Borna disease virus (2005)

International audience
Psicofarmacología y terapia de conducta. Origins of neuroscience. Guide for the care and use of laboratory animals. El cerebro íntimo. Ensayos sobre neurociencia (1997)

Con la reciente reforma de los planes de estudio de la licenciatura de Psicologia, la asignatura de Psicofarmacologia ha pasado a formar parte de una manera plenamente consolidada del curriculum academico que deberan cursar los futuros profesionales de la Psicologia en la casi totalidad de las Facultades de nuestro pais. 
Abordar con exito la realizacion de un texto sobre la historia de la Neurociencia amplia pero amena, exhaustiva pero concisa, debe ser una tarea que encierra una gran cantidad de dificultades. Sin embargo y a la vista del resultado, Stanley Finger a podido sortear todos los escollos y llevar a buen puerto el empeno. Este profesor del Departamento de Psicologia y del programa de Neurociencia de la Universidad de Washington en St. Louis ha realizado una obra de obligada referencia para todos aquellos interesados en los origenes de un conocimiento tan amplio y multidisciplinar como la Neurociencia.
En lo que concierne al tema del respeto y cuidado por la vida animal, no se caracteriza precisamente nuestro pais por una tradicion cultural e historica intachable. El mismo hecho de plantearse la existencia de derechos de los animales era considerado hasta hace unos anos algo ridiculo en gran parte de Europa (Contrepois, 1994).
Por fin se edita en nuestro pais un libro de Neurociencias escrito enteramente por los mas destacados neurocientificos espanoles. Este hecho, representa de por si un acontecimiento digno de ser alabado, y mas aun cuando las Neurociencias se encuentran de plena actualidad en estos anos 90, en la denominada «Decada del Cerebro» por el Congreso de los Estados Unidos.
Computed tomography angiography-derived extracellular volume fraction predicts early recovery of left ventricular systolic function after transcatheter aortic valve replacement (2020)

Increased myocardial ECV on CTA is associated with impaired LVEF recovery post-TAVR in severe AS patients with impaired LV systolic function.
The prolonged QT syndrome presenting as epilepsy (1994)

The prolonged QT syndrome is associated with ventricular tachyarrhythmias and sudden death. We report two patients and review eight previously reported cases of this syndrome, presenting as epilepsy. The average age at the time of the first convulsion was 4.7 years. Episodes were often infrequent, and the time to correct diagnosis ranged from 1 to 28 years. Only one-half the patients had histories suggestive of a familial syndrome. Presyncopal complaints and "lifelessness" prior to seizure activity were common findings in retrospect. Beta-blockade was effective in preventing recurrences in all patients who received treatment.
Ligand delivery by haem carrier proteins: the binding of Serratia marcescens haemophore to its outer membrane receptor is mediated by two distinct peptide regions (2003)

Haem is involved in essential processes. It is toxic and thus is not found free in living organisms but almost entirely sequestered by haem carrier proteins. We investigated the mechanisms of haem transfer between the proteins of a bacterial haem acquisition system involving haemophores. Haemophores are secreted by several Gram-negative bacteria and are able to extract haem (assimilated as an iron source) from haemoproteins and deliver it to specific outer membrane receptors. The Serratia marcescens haemophore (HasA) is folded into a globular form and tyrosine and histidine are involved in haem ligation. Interaction with the receptor is of high affinity (5 nM) and does not involve haem. Identification and study of mutants with altered binding properties led to the description of two regions of the haemophore that bind to the receptor. They consist of residues involved in two beta strands located on the same side of HasA. Each region is sufficient for high affinity binding. The synthetic peptide corresponding to one beta strand competes with the corresponding haemophore region for binding to the receptor, suggesting that the two binding regions are independent binding sites. We propose a model for haem release and transfer to the receptor.
Enzymatic synthesis optimization of isoamyl butyrate (2011)

Lipozyme TL IM was used to catalyse the esterification of isoamyl alcohol and butyric acid. A fractional factorial design was employed to evaluate the effects of temperature (30, 40, 50 °C), alcohol:acid molar ratio (1:1, 2:1, 3:1), enzyme concentration (0.003, 0.0115, 0.020 g mL-1), butyric acid concentration (0.1, 0.3, 0.5 mol L-1) and shaking rate (50, 115, 180 rpm) on the ester yield. With these results, the levels were redefined to a 2³ factorial design. The maximum yield of ester was obtained at 30 ºC, 180 rpm, alcohol:acid molar ratio of 1:1, enzyme concentration of 0.021 g mL-1 and butyric acid concentration of 0.5 mol L-1. Under the optimal conditions, 92% esterification was attained with an ester concentration of 0.9 mol L-1. Isoamyl alcohol from fusel oil was used under the same conditions and resulted in 93% esterification and an ester concentration of 1.0 mol L-1.
Overexpression of BMI‐1 correlates with drug resistance in B‐cell lymphoma cells through the stabilization of survivin expression (2011)

The expression of BMI-1 is correlated with disease progression in cancer patients. We showed that ectopic expression of BMI-1 in B-cell lymphoma cell lines, HT and RL, conferred resistance to etoposide and oxaliplatin, known to enhance sensitivity by targeting the survivin gene, but not to irinotecan, which is not relevant to the downregulation of survivin expression. The expression of survivin was not only augmented in cells transduced with BMI-1, but persisted in the presence of etoposide in cells overexpressing BMI-1. By contrast, the mock-transduced cells succumbed in the medium with anticancer drugs, with an accompanying decrease in BMI-1 and survivin expression. BMI-1 overexpression stabilized survivin post-translationally without an accompanying rise in the mRNA, suggesting survivin as a potential target for BMI-1. Knockdown of either BMI-1 or survivin restored sensitivity to etoposide in the BMI-1-overexpressing lymphoma cells. An analysis of six patients with B-cell lymphoma showed that in the drug-resistant patients, levels of BMI-1 and survivin were maintained even after drug administration. However, downregulation of both BMI-1 and survivin expression was observed in the drug-sensitive patients. Therefore, BMI-1 might facilitate drug resistance in B-cell lymphoma cells through the regulation of survivin. BMI-1 could be an important prognostic marker as well as a future therapeutic target in the treatment of drug-resistant lymphomas.