gebhart/patrepeval huggingface dataset:
37 Cardiovascular Effects of Unilateral Nephrectomy in Human Kidney Donors (2015)

<h3>Introduction</h3> There is a graded association between chronic kidney disease and cardiovascular (CV) risk but proof of causality is lacking and the pathophysiological mechanisms responsible for this relationship remain unclear. We hypothesised that the reduction in glomerular filtration rate (GFR) accompanying nephrectomy in live kidney donors causes increased left ventricular (LV) mass, impaired LV function and increased aortic stiffness. <h3>Methods</h3> This was a multicentre, parallel group, blinded end point study of live kidney donors and healthy controls (n = 124). The primary outcome was change in LV mass assessed by MRI (baseline to 12 months). Pre-specified secondary outcomes included changes in: isotopic GFR; LV strain; blood pressure (BP); aortic pulse wave velocity (PWV) and distensibility; and cardiac biomarkers. <h3>Results</h3> When compared to controls, LV mass (+7 +/- 10 g vs. −3 +/- 8 g; P &lt; 0.001), LV mass-volume ratio (+0.06 +/- 0.12 g/ml vs. −0.01 +/- 0.09 g/ml; P &lt; 0.01) and PWV (+0.5 +/- 0.9 m/s vs. −0.1 +/- 0.7 m/s; P &lt; 0.001) were increased in donors. Aortic distensibility (−0.29 +/- 1.38 × 10<sup>–3</sup> mmHg<sup>-1 </sup>vs. +0.28 +/- 0.79 × 10<sup>–3</sup> mmHg<sup>-1</sup>; P = 0.03) and global circumferential strain (−1.1 +/- 3.8% vs. +0.4 +/- 2.4%; P = 0.04) were reduced in donors. The decrease in GFR (−30 +/- 12 mL/min/1.73 m<sup>2</sup>) in donors was accompanied by increases in uric acid (+56 +/- 35 micromol/L vs. +2 +/- 33 micromol/L; P &lt; 0.001), parathyroid hormone (+1.1 +/- 1.6 pg/mL vs. +0.4 +/- 1.3 pg/mL; P = 0.03) and hs-CRP (+1.7 +/- 5.3 mg/dl vs. -0.7 +/- 5.2 mg/dL; P &lt; 0.01), with greater risks of developing detectable hs-Troponin T (21% vs. 2%; OR 16.2; P &lt; 0.01) and microalbuminuria (7% vs. 0%; OR 3.74; P = 0.04). There were no significant changes in circulating levels of renin or aldosterone and no changes in brachial or central BP. Change in GFR was an independent predictor of the change in LV mass after adjustment for age, sex, baseline LV mass, and 12-month changes in BP, uric acid and parathyroid hormone (Beta = −0.3, R<sup>2</sup> = 0.31, P = 0.002). <h3>Conclusions</h3> A modest reduction in GFR causes increased LV mass, LV systolic dysfunction, increased aortic stiffness and adverse changes to CV biomarkers. Reduced GFR should be regarded as an independent causative CV risk factor.
Reactive Plasmacytoses Are Expansions of Plasmablasts Retaining the Capacity to Differentiate Into Plasma Cells (1999)

Circulating plasma cells in 10 cases of reactive plasmacytosis had a shared phenotype with early plasma cell (CD19(+) CD38(+) CD138(+) CD40(+) CD45(+) CD11a+ CD49e- CD56(-)). In most cases, a minor subpopulation of CD28(+) plasma cells was also detected. Reactive plasma cells were highly proliferative, suggesting the presence of circulating progenitors (plasmablasts). After CD138(+) plasma cell removal, highly proliferative CD138(-) plasmablasts differentiated into CD138(+) plasma cells within a few days. This differentiation, which was associated with increased CD38 and decreased HLA-DR expression, was further confirmed by a large increase in intracellular Ig content (associated with Ig secretion) and was concomitant with extensive secretion of interleukin-6 (IL-6). The addition of neutralizing anti-IL-6 and anti-CD126 (IL-6 receptor) monoclonal antibodies totally prevented Ig secretion and cell differentiation by inducing apoptosis of plasmablasts, which indicates that IL-6 is an essential survival factor for plasmablasts. This report provides the first characterization of normal plasmablasts and shows that their phenotype is not exactly that of multiple myeloma cells.
A nanometric DNA-zwitterionic phospholipid unilamellar vesicle formulation compacted for gene delivery: Adiabatic differential scanning microcalorimetric study (2004)

S uleymano ( glu,E. A nanometric DNA-zwitterionic phospholipid unilamellar vesicle formulation compacted for gene delivery: Adiabatic differential scanning microcalorimetric study Songklanakarin J. Sci. Technol., 2004, 26(4) : 479-483 Complexes between nucleic acids and phospholipid vesicles have been developed as stable non-viral gene delivery vehicles. Currently employed approach uses positively charged lipid species and a helper zwitterionic lipid, the latter being applied for the stabilization of the whole complex. However, besides problematic steps during their preparation, cationic lipids are toxic for cells. Present work describes some energetics issues pertinent to preparation and use of neutral lipid-DNA self-assemblies, thus avoiding toxicity of lipoplexes. Differential scanning calorimetry data showed stabilization of polynucleotide helix upon its interaction with liposomes in the presence of divalent metal cations. It is thus possible to suggest this selfassembly as an improved formulation for use in gene delivery.
Fe-Catalyzed Phenanthrene Synthesis via [4+2] Benzannulation (2011)

Corrected by: Fe-Catalyzed Phenanthrene Synthesis via [4+2] BenzannulationSynfacts 2011; 2011(11): 1263-1263DOI: 10.1055/s-0031-1289298
Evolution and distribution of RNA polymerase II regulatory sites from RNA polymerase III dependant mobile Alu elements (2004)

Our study clearly suggests that Alu elements, through retrotransposition, could distribute functional and regulatable promoter elements, which in the course of subsequent selection might be stabilized in the genome. Exaptation of regulatory elements in the preexisting genes through Alus could thus have contributed to evolution of novel regulatory networks in the primate genomes. With such a wide spectrum of regulatory sites present in Alus, it also becomes imperative to screen for variations in these sites in candidate genes, which are otherwise repeat-masked in studies pertaining to identification of predisposition markers.
Alkaline phosphatase activity after cardiothoracic surgery in infants and correlation with post-operative support and inflammation: a prospective cohort study (2012)

Alkaline phosphatase activity decreases after cardiothoracic surgery in infants. Low post-operative alkaline phosphatase activity is independently associated with increased procalcitonin, increased vasoactive/inotropic support, prolonged intubation time, and prolonged hospital stay. Alkaline phosphatase may serve as a biomarker and potential modulator of post-operative support and inflammation following cardiothoracic surgery in infants.
Data from Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;CCR8 is a chemokine receptor expressed principally on regulatory T cells (Treg) and is known to be critical for CCR8&lt;sup&gt;+&lt;/sup&gt; Treg-mediated immunosuppression. Recent studies have demonstrated that CCR8 is uniquely upregulated in human tumor-resident Tregs of patients with breast, colon, and lung cancer when compared with normal tissue-resident Tregs. Therefore, CCR8&lt;sup&gt;+&lt;/sup&gt; tumor-resident Tregs are rational targets for cancer immunotherapy. Here, we demonstrate that mAb therapy targeting CCR8 significantly suppresses tumor growth and improves long-term survival in colorectal tumor mouse models. This antitumor activity correlated with increased tumor-specific T cells, enhanced infiltration of CD4&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt; T cells, and a significant decrease in the frequency of tumor-resident CD4&lt;sup&gt;+&lt;/sup&gt;CCR8&lt;sup&gt;+&lt;/sup&gt; Tregs. Tumor-specific CD8&lt;sup&gt;+&lt;/sup&gt; T cells displayed lower expression of exhaustion markers as well as increased functionality upon restimulation. Treatment with anti-CCR8 mAb prevented &lt;i&gt;de novo&lt;/i&gt; induction and suppressive function of Tregs without affecting CD8&lt;sup&gt;+&lt;/sup&gt; T cells. Initial studies explored a combinatorial regimen using anti-CCR8 mAb therapy and a &lt;i&gt;Listeria monocytogenes&lt;/i&gt;–based immunotherapy. Anti-CCR8 mAb therapy synergized with &lt;i&gt;L. monocytogenes&lt;/i&gt;–based immunotherapy to significantly delay growth of established tumors and to prolong survival. Collectively, these findings identify CCR8 as a promising new target for tumor immunotherapy and provide a strong rationale for further development of this approach, either as a monotherapy or in combination with other immunotherapies.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Significance:&lt;/b&gt; Inhibition of CCR8 represents a promising new cancer immunotherapy strategy that modulates tumor-resident regulatory T cells to enhance antitumor immunity and prolong patient survival. &lt;i&gt;Cancer Res; 78(18); 5340–8. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Novel 2-Amino-1,4-dihydropyridine Calcium Antagonists. I. Synthesis and Antihypertensive Effects of 2-Amino-1,4-dihydropyridine Derivatives Having Nitroxyalkoxycarbonyl Groups at 3- and/or 5-Position. (1995)

Novel 2-amino-1,4-dihydropyridine derivatives I, which contain N,N,-dialkylaminoalkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their antihypertensive effects were evaluated in spontaneously hypertensive rats. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced into either the 3- and/or 5-ester side-chain of the 1,4-dihydropyridine ring. In particular, the compounds containing cyclic amino moieties at the 3-position showed greater potency than those with acyclic amino moieties. Chemical modification studies indicated that the two ester side-chains of 1,4-dihydropyridine at the 3- and 5-position might function in a different manner in relation to the antihypertensive activities. 3-(1-Benzhydrylazetidinited potent and long-lasting antihypertensive effects with gradual onset of action, and is a promising candidate as an antihypertensive drug.
Stents are used too often (1998)

We can forgive a man for making a useful thing as long as he does not admire it. The only excuse for making a useless thing is that one admires it intensely.
Reduced cell surface expression of processed human immunodeficiency virus type 1 envelope glycoprotein in the presence of Nef (1993)

nef genes from two laboratory grown human immunodeficiency virus type 1 (HIV-1) strains and from two proviruses that had not been propagated in vitro were introduced into CD4+ lymphoblastoid CEM cells. The stable expression of all four Nef proteins was associated with an almost complete abrogation of CD4 cell surface localization. The consequences of the presence of Nef on gp160 cleavage, gp120 surface localization, and envelope-induced cytopathic effect were examined in CEM cells in which the HIV-1 env gene was expressed from a vaccinia virus vector. The presence of Nef did not modify the processing of gp160 into its subunits but resulted in a significant decrease of cell surface levels of gp120, associated with a dramatic reduction of the fusion-mediated cell death. Surface levels of mutant envelope glycoproteins unable to bind CD4 were not altered in Nef-expressing cells, suggesting that the phenomenon was CD4 dependent. The intracellular accumulation of fully processed envelope glycoproteins could significantly delay the cytopathic effect associated with envelope surface expression in HIV-infected cells and may be relevant to the selective advantage associated with Nef during the in vivo infectious process.
원저 : 저혈량성 쇼크 환자에서 병원 내 사망률 예측과 초기 소생술의 치료 지표로서 쇼크인덱스, 혈청 젖산 농도, 동맥혈-호기말 이산화탄소 분압차의 유용성 (2007)

Purpose: To determine whether differences in arterial and end-tidal carbon dioxide [P(a-et)CO2], shock index, and serum lactate levels are helpful for predicting the outcome of resuscitation in hypovolemic shock patients in the emergency department. Methods: A prospective study of end-tidal carbon dioxide (EtCO2)-derived variables and patient outcomes in hypovolemic shock was conducted in the emergency department of a university hospital from January 2005 to February 2006. A total of fifty-eight hypovolemic shock patients over 20 years old were included. During resuscitation, patients received volume replacement including blood transfusions, as well as vasopressor or inotropic therapy if needed. Results: Twenty-one patients died in the hospital. At the time of admission (hour 0) and after resuscitation (hour 4), there were no differences related to age, respiration and heart rate, CVP, arterial blood gases, or EtCO2 between survivors and non-survivors. Non-survivors had significantly higher shock index scores, serum lactate levels, and P(a-et) CO2 than the survivors. The Receiver operator characteristic (ROC) curves at hour 4 hour for P(a-et)CO2 were as effective for predicting mortality as were the shock index and serum lactate levels. Shock index > 1.0, P(a-et)CO2 > 4 mmHg, and serum lactate > 5.0 mmol/L after resuscitation were all associated with a high early mortality rate (p=0.074, 0.001, 0.000, respectively). Conclusion: P(a-et)CO2, shock index, and serum lactate levels are predictive of in-hospital mortality and may be useful as guidelines in the resuscitation of hypovolemic shock patients in the emergency department.
Semiclassical Theory of Linear Magnetoresistance in Crystalline Conductors with Broken Time-Reversal Symmetry (2015)

Onsager relations permit linear response of the resistivity to an external magnetic field only when time reversal symmetry is broken. By employing semiclassical Boltzmann transport theory generalized to account for anomalous velocities and orbital and spin magnetic moments, we obtain an explicit expression for the linear magnetoresistance of a crystalline conductor. Like the anomalous Hall effect, also permitted only when time-reversal symmetry is broken, it includes both intrinsic and extrinsic contributions. The intrinsic linear magnetoresistance, which is dominant in strongly disordered systems, is due to the influence on transport of momentum-space Berry curvatures and momentum-dependent Bloch state magnetic moments. For the case of surface state transport in magnetically ordered topological insulators we predict positive magneto-resistance that is linear in field but independent of field direction.
Image Quality Assessment Using Regularity of Color Distribution (2016)

To quantify the perceptual quality of the color image, a novel reduced-reference computational model is proposed in this paper. The proposed metric, named regularity of color distribution measure, is designed to measure the difference of the color distribution regularity between the reference image and the distorted one. In particular, three kinds of channels (bright channel, median channel, and dark channel) are first extracted from the color image. Then, a fractal analysis is employed to characterize each channel by fractal dimension. Finally, we make use of fractal dimensions extracted from channels to predict the image quality. The proposed metric is evaluated on three largest color image databases (TID2013, CSIQ, and LIVE databases) and experimental results indicate that our metric achieves excellent performance.
Uncharted Lines (2000)

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Periodic fever and erythema nodosum associated with MDS with trisomy 8: report of two cases and review of the literature (2010)

We report two cases of myelodysplastic syndrome (MDS) with trisomy 8 who had periodic fever and erythema nodosum (EN). A 74-year-old man showed periodic fever and EN. A diagnosis of MDS with trisomy 8 was made, and he was successfully treated with prednisolone (PSL). A 71-year-old man presented with intermittent fever, EN, and recurrent elevation of myogenic enzymes. Despite sustained inflammation, laboratory tests showed macrocytic anemia and thrombocytopenia. Marrow aspiration showed MDS with the chromosomal abnormality trisomy 8. He was successfully treated with PSL without repeated transient fever and elevation of creatine kinase. The results of a literature review of 35 cases of MDS with trisomy 8 and Behçet’s disease-like symptoms, such as EN, oral ulcer and intestinal ulcer, suggest that the disease entity of “trisomy 8 syndrome” may be considered, and that it is an important differential diagnosis of periodic fever and EN.
Cryptosporidium parvumIsolate-Dependent Postinfectious Jejunal Hypersensitivity and Mast Cell Accumulation in an Immunocompetent Rat Model (2009)

Cryptosporidium spp. are a cause of self-limited diarrhea in immunocompetent hosts. In immunocompetent rats, Cryptosporidium parvum infection induced digestive hypersensitivity, a key pathophysiological factor in functional digestive disorders such as irritable bowel syndrome (IBS). In such a rat model, we sought to document whether jejunal hypersensitivity depends on C. parvum isolate and is associated with a mast cell accumulation. Five-day-old rats were orally administered 10(5) oocysts of either Nouzilly (NoI) or Iowa (IoI) C. parvum isolate. NoI-infected rats exhibited the lowest food intake on days 7 and 14 postinfection (p.i.). On day 7 p.i., small intestine villus atrophy, crypt hyperplasia, and inflammatory cell infiltration were prominent in NoI-infected rats, with higher numbers of Cryptosporidium forms than in IoI-infected rats. Compared to uninfected control rats, jejunal intraepithelial lymphocytes (IELs) were increased only in NoI-infected rats on day 14 p.i. On day 50 p.i., jejunal hypersensitivity to distension was found only in NoI-infected rats; this hypersensitivity is associated with activated mast cell accumulation. The number of mast cells in the jejunal lamina propria was increased from day 36 p.i. in NoI-infected rats and only at day 120 p.i. in IoI-infected rats. Our data suggest that both the severity of infection (weight loss, reduced food intake, villus atrophy, and IEL accumulation) and the onset of a jejunal hypersensitivity after infection in association with an activated mast cell accumulation are isolate dependent and related to NoI infection. This cryptosporidiosis rat model is a relevant model for the study of underlying mechanisms of postinfectious IBS-like symptoms.
UnsuperPoint: End-to-end Unsupervised Interest Point Detector and Descriptor (2019)

It is hard to create consistent ground truth data for interest points in natural images, since interest points are hard to define clearly and consistently for a human annotator. This makes interest point detectors non-trivial to build. In this work, we introduce an unsupervised deep learning-based interest point detector and descriptor. Using a self-supervised approach, we utilize a siamese network and a novel loss function that enables interest point scores and positions to be learned automatically. The resulting interest point detector and descriptor is UnsuperPoint. We use regression of point positions to 1) make UnsuperPoint end-to-end trainable and 2) to incorporate non-maximum suppression in the model. Unlike most trainable detectors, it requires no generation of pseudo ground truth points, no structure-from-motion-generated representations and the model is learned from only one round of training. Furthermore, we introduce a novel loss function to regularize network predictions to be uniformly distributed. UnsuperPoint runs in real-time with 323 frames per second (fps) at a resolution of $224\times320$ and 90 fps at $480\times640$. It is comparable or better than state-of-the-art performance when measured for speed, repeatability, localization, matching score and homography estimation on the HPatch dataset.
Suppression of Neuronal Hyperexcitability and Associated Delayed Neuronal Death by Adenoviral Expression of GABACReceptors (2001)

The excessive neuronal excitation underlying several clinically important diseases is often treated with GABA allosteric modulators in an attempt to enhance inhibition. An alternative strategy would be to enhance directly the sensitivity of postsynaptic neurons to GABA. The GABA(C) receptor, normally found only in the retina, is more sensitive to GABA and demonstrates little desensitization compared with the GABA(A) receptor. We constructed an adenovirus vector that expressed cDNA for both the GABA(C) receptor rho(1) subunit and a green fluorescent protein (GFP) reporter and used it to transduce cultured hippocampal neurons. Transduced neurons were identified by fluorescence, double immunocytochemistry proved colocalization of the rho(1) protein and the reporter, Western blot verified the expected molecular masses, and electrophysiological and pharmacological properties confirmed the presence of functional GABA(C) receptors. rho(1)-GFP transduction resulted in an increased density of GABA(A) receptors as well as expression of novel GABA(C) receptors. This effect was not reproduced by addition of TTX or Mg(2+) to the culture medium to reduce action potentials or synaptic activity. In a model of neuronal hyperexcitability induced by chronic blockade of glutamate receptors, expression of GABA(C) receptors abolished the hyperactivity and the consequent delayed neuronal death. Adenovirus-mediated neuronal GABA(C) receptor engineering, via its dual mechanism of inhibition, may offer a way of inhibiting only those hyperexcitable neurons responsible for clinical problems, avoiding the generalized nervous system depression associated with pharmacological therapy.
Altered neurogenesis in mouse models of Alzheimer disease (2017)

Amyloid-β (Aβ) peptides, as well as a variety of other protein fragments, are derived from proteolytical cleavage of the amyloid precursor protein (APP) and have been demonstrated to play a key role in the pathological changes underlying Alzheimer disease (AD). In AD mouse models, altered neurogenesis has been repeatedly reported to be associated with further AD-typical pathological hallmarks such as extracellular plaque deposition, behavioral deficits or neuroinflammation. While a toxic role of Aβ in neurodegeneration and impaired neuronal progenitor proliferation is likely and well-accepted, recent findings also suggest an important influence of APP-derived proteolitical fragments like the APP intracellular domain (AICD), as well as of APP itself.