gebhart/patrepeval huggingface dataset:
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3* Nicotinic Receptors (2019)

A three-dimensional database search has been applied to design a series of endo- and exo-3-(pyridin-3-yl)bicyclo[2.2.1]heptan-2-amines as nicotinic receptor ligands. The synthesized compounds were tested in radioligand binding assay on rat cortex against [<sup>3</sup>H]-cytisine and [<sup>3</sup>H]-methyllycaconitine to measure their affinity for α4β2* and α7* nicotinic receptors. The new derivatives showed some preference for the α4β2* over the α7* subtype, with their affinity being dependent on the endo/exo isomerism and on the methylation degree of the basic nitrogen. The endo primary amines displayed the lowest K<sub>i</sub> values on both receptor subtypes. Selected compounds (1a, 2a, 3a, and 6a) were tested on heterologously expressed α4β2, α7, and α3β2 receptors and on SHSY-5Y cells. Compounds 1a and 2a showed α4β2 antagonistic properties while behaved as full agonists on recombinant α7 and on SHSY5Y cells. On the α3β2 subtype, only the chloro derivative 2a showed full agonist activity and submicromolar potency (EC<sub>50</sub> = 0.43 μM). The primary amines described here represent new chemotypes for the α7 and α3* receptor subtypes.
Health vlogger-viewer interaction in chronic illness management (2013)

Health video blogs (vlogs) allow individuals with chronic illnesses to share their stories, experiences, and knowledge with the general public. Furthermore, health vlogs help in creating a connection between the vlogger and the viewers. In this work, we present a qualitative study examining the various methods that health vloggers use to establish a connection with their viewers. We found that vloggers used genres to express specific messages to their viewers while using the uniqueness of video to establish a deeper connection with their viewers. Health vloggers also explicitly sought interaction with their viewers. Based on these results, we present design implications to help facilitate and build sustainable communities for vloggers.
Abstract P611: Vascular-mediated Preterm Birth is Associated with Cardiovascular Risk after Pregnancy (2015)

Objective: To investigate whether preterm birth and placental evidence of malperfusion is associated with subclinical atherosclerosis and a higher cardiovascular risk factor burden 4 to 12 years after pregnancy. Methods: A cohort of women with preterm (n=119) and term births (n=242), mean age 38 years, was examined on average eight years after pregnancy for carotid artery intima-media thickness (IMT), fasting lipids, blood pressure and inflammatory markers (C-reactive protein [hsCRP] and Interleukin-6 [IL-6]). Pregnancy characteristics included placental pathology evidence of malperfusion (vasculopathy, infarct, advanced villous maturation, perivillous fibrin, fibrin deposition), infection (chorioamnionitis, funisitis, deciduitus), villitis (chronic inflammation), fetal thrombosis or chorangiosis. Vascular-mediated preterm births were those with malperfusion lesions, and by design, those with preeclampsia were excluded. Results: Women with malperfusion lesions had a higher mean carotid IMT (+0.055 cm), total cholesterol (+17.49 mg/dl), LDL-C (+11.44), triglycerides (+17%), apolipoprotein-B (+8.95) and systolic and diastolic blood pressure (+4.58/+2.62 mmHg) compared to women with term births, independent of age, race, smoking and adiposity assessed before and after pregnancy (all p&lt;0.05). Women with preterm birth and evidence of malperfusion accompanied by other lesions related to infection or chronic inflammation had the most atherogenic profile after pregnancy, and carotid IMT differences were independent of traditional risk factors (+0.04 cm; p=0.027). Conclusions: Vascular-mediated preterm birth is associated with maternal subclinical atherosclerosis and a higher cardiovascular risk factor burden in the decade after pregnancy compared to term birth. The placenta may offer unique insight into how pregnancy complications can portend the emergence of maternal cardiovascular disease.
Contingent Product Design and Marketing Strategies Influencing New Product Success and Failure in U.S. and Japanese Electronics Firms (1997)

The commercial success or failure of a product doesn't rest solely on the whims of the marketplace. The myriad, often interdependent, strategic trade‐offs made throughout the product development process go a long way toward determining whether a product succeeds or fails. The key to success often rests in finding the right combination of product design and market choice decisions. Toward that end, William E. Souder and X. Michael Song examine the relationship between product success and several product design and market choice strategies. In particular, they explore the possibility that the correct strategy combination differs depending on a firm's perception of market uncertainty, which they measure in terms of the respondents' perceived familiarity with the market for a product, perceived understanding of customer needs, and perceived capability to translate those needs into product performance specifications. Recognizing that the correct combination of strategic choices may also depend on firm size, industry, and culture, the study focuses on small U.S. suppliers of electronics components. Fortune 500 producers of electronics final products, and Japanese producers of electronics final products. For the small U.S. firms in the study, an emphasis on performance superiority, technical superiority, or radically new products provides a recipe for failure under low market uncertainty. Even under high market uncertainty, these characteristics do not equate to success for the small U.S. firms in this study. The findings suggest that these firms should focus on design compatibility with a purchaser's installed base. The responses from Fortune 500 firms and Japanese companies indicate that under low market uncertainty these larger organizations should consider emphasizing compatibility and avoiding radical designs. For markets that the larger firms perceive to be highly uncertain, the results suggest that these companies should emphasize performance superiority, technical superiority, and radical designs. The findings related to market choice strategies also support the notion that the correct combination of strategic decisions depends on firm size, culture, and the perceived level of market uncertainty. However, the guidelines presented in this study should not be construed as hard‐and‐fast rules for formulating product strategy. Instead, the results presented here will be helpful for challenging assumptions and guiding actions, as one element in the effort to shape an effective product strategy.
Effect of P2O5 and AlPO4 Coating on LiCoO2 Cathode Material. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Substituent‐Induced Supramolecular Aggregates of Edge Functionalized Nanographenes (Small 31/2023) (2023)

Edge Functionalized Nanographenes The aggregation of nanographenes (NGs) are controlled by the introduction of tris(phenylisoxazolylbenzenes (TPIB) at the edge. The TPIB unit creates the intermolecular dipole-dipole and staking interactions that drive the one-dimensional arrangement of nanographenes. The supramolecular polymeric network structures are visualized by atomic force microscopy. The synergy of the face-to-face interactions between the nanographene surfaces and the interactions between the TPIB units determines the self-assembly of the NGs. More details can be found in article number 2207475 by Ryo Sekiya, Takeharu Haino, and Haruka Moriguchi.
Respiratory Volumes in Normal Speech: A Possible Reason for Intraoral Pressure Differences among Voiced and Voiceless Consonants (1969)

Respiratory volumes during phonation of a series of voiced and voiceless fricatives and plosives placed within a carrier phrase were measured in 20 normal adult subjects. The purpose was to (1) determine whether consonant type influences respiratory volume and (2) determine whether intraoral pressure differences among voiced-voiceless consonants could be a reflection of volume differences during speech. The results indicate that voiceless consonants utilize substantially larger volumes of air than their voiced cognates. The data also suggest that consonant intraoral pressures may be influenced more by intraoral respiratory volumes than by energy losses caused by glottal resistance during voicing.
Improved Submatrix Maximum Queries in Monge Matrices (2013)

We present efficient data structures for submatrix maximum queries in Monge matrices and Monge partial matrices. For $n\times n$ Monge matrices, we give a data structure that requires O(n) space and answers submatrix maximum queries in $O(\log n)$ time. The best previous data structure [Kaplan et al., SODA`12] required $O(n \log n)$ space and $O(\log^2 n)$ query time. We also give an alternative data structure with constant query-time and $ O(n^{1+\varepsilon})$ construction time and space for any fixed $\varepsilon&lt;1$. For $n\times n$ {\em partial} Monge matrices we obtain a data structure with O(n) space and $O(\log n \cdot α(n))$ query time. The data structure of Kaplan et al. required $O(n \log n \cdot α(n))$ space and $O(\log^2 n)$ query time. Our improvements are enabled by a technique for exploiting the structure of the upper envelope of Monge matrices to efficiently report column maxima in skewed rectangular Monge matrices. We hope this technique can be useful in obtaining faster search algorithms in Monge partial matrices. In addition, we give a linear upper bound on the number of breakpoints in the upper envelope of a Monge partial matrix. This shows that the inverse Ackermann $α(n)$ term in the analysis of the data structure of Kaplan et. al is superfluous.
Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients (2023)

Even though obsessive compulsive disorder (OCD) is one of the ten most disabling diseases according to the WHO, only 30-40% of patients suffering from OCD seek specialized treatment. The currently available psychotherapeutic and pharmacological approaches, when properly applied, prove ineffective in about 10% of cases. The use of neuromodulation techniques, especially Deep Brain Stimulation, is highly promising for these clinical pictures and knowledge in this domain is constantly evolving. The aim of this paper is to provide a summary of the current knowledge about OCD treatment, while also discussing the more recent proposals for defining resistance.
[Viscoelastic behaviour of inlay waxes. (Part 2) Physical and dynamic viscoelastic properties for binary mixtures of waxes (author's transl)]. (1981)

Binary mixtures of waxes added carnauba wax, beeswax or dammar to paraffin were investigated by measurements of X-ray diffraction, dilatometry, differential thermal analysis and dynamic viscoelasticity. The relationships between the viscoelastic behaviour and the physical properties of these waxes were discussed. Additions of carnauba wax to paraffin changed drastically viscoelastic properties of paraffin, that is, increased the dynamic modulus, G', and decreased the loss tangent, tan delta, in the region of higher temperatures including the crystal transition temperature region of paraffin. The possible explanation for this change of viscoelastic properties is that the presence of crystals of carnauba wax composed of longer chain molecules than that of paraffin rises interfacial interaction. The temperature dependence of viscoelastic properties for binary mixtures of paraffin and beeswax was approximately the same as that of paraffin. This is because paraffin and beeswax may form a sort of homogeneous phases. Additions of dammar to paraffin increased the elasticity of paraffin in the region of lower temperatures, but did not effected to change of G' and tan delta in the region of higher temperatures. Another effect of additions of dammar was to lower the thermal expansion of binary mixtures.
Synthesis of estriol 16α-(α-D-glucoside) by enzymic transglucosylation (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of estriol 16α-(α-D-glucoside) by enzymic transglucosylationSamuel C. PanCite this: Biochemistry 1970, 9, 8, 1833–1838Publication Date (Print):April 1, 1970Publication History Published online1 May 2002Published inissue 1 April 1970https://pubs.acs.org/doi/10.1021/bi00810a025https://doi.org/10.1021/bi00810a025research-articleACS PublicationsRequest reuse permissionsArticle Views63Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
100-Gb/s Physical-Layer Architecture for Next-Generation Ethernet (2006)

A high-speed physical-layer architecture for Ethernet is described that supports 100-Gb/s throughput and 40-km transmission, making it well suited for next-generation metro-area and intrabuilding networks. Its links comprise 12 x 10-Gb/s synchronized parallel optical lanes. Ethernet data frames are transmitted by coarse wavelength division multiplexing link and bundled optical fibers. Ten of the lanes convey 640-bit data synchronously (64 bits x 10 lanes). One conveys forward error correction code ((132b, 140b) Hamming code), providing highly reliable (BER < 10 -12 ) data transmission, and the other conveys parity data, enabling faultlane recovery. A newly developed 64B/66B code-sequence-based deskewing mechanism is used that provides low-latency compensation for the lane-to-lane skew, which is less than 88 ns. Testing of this physical-layer architecture in a field programmable gate array circuit demonstrated that it can provide 100-Gb/s data communication with a 590k gate circuit, which is small enough for implementation in a single LSI circuit.
Estrogen effects on the brain. (2001)

This article reviews available data on the effects of estrogen on the brain. Such information is derived from basic laboratory studies, inferences from comparisons of gender differences, observational epidemiologic studies, and clinical trials of estrogen in humans. Findings suggest the potentially favorable influences of estrogen on mood and cognition in older women and augment current knowledge about physical risks and benefits of estrogen use.
Proxemic zones of exhibits and their manipulation using floor projection (2016)

We investigate intimate proxemic zones of exhibits, which are zones that visitor will respect and hence not enter. In a first experiment we show that exhibits have, like humans, an intimate proxemic zone that is respected by exhibition visitors and which is 27cm. A zone around an exhibit that visitors will not enter can be increased through lines projected on the floor. In a second experiment we showed that for distances larger than 95cm, static lines will not protect the intimate zone of the exhibit anymore, but animated or color changing lines will do and allow for dynamically changing the zone size. This paper provides fundamental insight in intimate proxemic zones of exhibits and about how we can use interactive floor projections to manipulate these zones in the context of exhibitions. That might be used, for example, to increase the safety zone of exhibits if the room is crowded.
Polyhydroxyalkanes from Furfural Condensation Products (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolyhydroxyalkanes from Furfural Condensation ProductsCharles R. Russell, Kliem Alexander, W. O. Erickson, L. S. Hafner, and L. E. SchnieppCite this: J. Am. Chem. Soc. 1952, 74, 18, 4543–4546Publication Date (Print):September 1, 1952Publication History Published online1 May 2002Published inissue 1 September 1952https://pubs.acs.org/doi/10.1021/ja01138a025https://doi.org/10.1021/ja01138a025research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the capacity of the discrete-time channel with uniform output quantization (2009)

This paper provides new insight into the classical problem of determining both the capacity of the discrete-time channel with uniform output quantization and the capacity achieving input distribution. It builds on earlier work by Gallager and Witsenhausen to provide a detailed analysis of two particular quantization schemes. The first is saturation quantization where overflows are mapped to the nearest quantization bin, and the second is modulo quantization where overflows are mapped to the nearest quantization bin after reduction by some modulus. Both the capacity of modulo quantization and the capacity achieving input distribution are determined. When the additive noise is gaussian and relatively small, the capacity of saturation quantization is shown to be bounded below by that of modulo quantization. In the limit of arbitrarily many uniform quantization levels, it is shown that the difference between the upper and lower bounds on capacity given by Ihara is only 0.26 bits.
[Immunocytochemical and ultrastructural study of saphenous vein, internal thoracic artery, and right gastroepiploic artery in coronary artery bypass grafting]. (1993)

The arterial conduits such as internal thoracic artery (ITA) and right gastroepiploic artery (GEA) are widely used in coronary artery bypass surgery because of their resistance to atherosclerosis. In this study, immunophenotypes of smooth muscle cells (SMCs) in intima and media of ITA, GEA and saphenous vein (SV) were studied using monoclonal antibodies specific to cytoskeletal proteins; actin (A), vimentin (V) and desmin (V). In addition, the ultrastructures of endothelium of these vessels were examined. The most SMCs in intima and media of ITA and GEA were found positive for (A) and (V) but negative for (D). In contrast, the majority of SMCs both in intima and media of SV were found positive for (A), (V) and (D). The ultrastructure of endothelium of ITA and GEA showed the deeper penetration of cytoplasmic process than SV, which might anchor the endothelium. We suggest the morphological difference of endothelium and phenotypic diversity of SMCs between arterial and venous grafts may account for the different susceptibility to atherosclerotic changes in coronary bypass grafting.
Abstract IA26: Reprogramming tumor-associated macrophages by targeting PI3K-gamma with IPI-549 (2020)

Abstract The PI3 kinases (PI3K) belong to a family of signal-transducing enzymes that mediate key cellular functions in cancer and immunity. The PI3K-gamma (γ) isoform is highly expressed in myeloid cells/macrophages and plays an important role in M2 macrophage polarization (Kaneda, Nature 2016). PI3K-γ knockout mice also demonstrated the role for PI3K-γ in tumor growth and immune tolerance (Gunderson, Cancer Discovery 2015; Kaneda, 2016). IPI-549 is an oral, potent, and selective inhibitor of PI3K-γ that shows single-agent antitumor activity in multiple murine tumor models (Kaneda, 2016) and enhanced antitumor activity and improved survival when combined with immune-checkpoint blockade (ICB) (De Henau, Nature 2016). This antitumor activity is dependent on the presence of both immune-suppressive tumor-associated CD11b+ myeloid cells and CD8+ cytotoxic T cells. IPI-549 can reduce the suppression of T-cell activity by both murine and human myeloid-derived suppressor cells in vitro and in vivo. IPI 549 treatment of tumor-bearing mice leads to a shift in tumor-associated myeloid cells from an immunosuppressive M2 phenotype to a proinflammatory M1 phenotype and an increased frequency of circulating tumor-specific T cells and tumor-infiltrating CD8+ T cells. In addition, preclinical tumor model systems show that resistance to ICB is directly mediated by the suppressive activity of infiltrating myeloid cells (De Henau, Nature 2016). Treatment of ICB-resistant 4T1 and B16GMCSF tumor-bearing mice with IPI-549 and anti-PD1 for 14 days led to a significant antitumor activity and an increased CD8+/T-reg cell ratio, confirming that selective pharmacologic targeting PI3K-γ by IPI-549 restores sensitivity to ICB. We are conducting a Ph 1/1b study IPI-549-01 (ClinicalTrials.gov NCT02637531) evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunomodulatory activity of IPI-549 to determine its recommended phase 2 dose and preliminary clinical activity, as both a monotherapy and in combination with nivolumab, in patients with advanced solid tumors. Citation Format: Jeffery L. Kutok. Reprogramming tumor-associated macrophages by targeting PI3K-gamma with IPI-549 [abstract]. In: Proceedings of the AACR Special Conference on Targeting PI3K/mTOR Signaling; 2018 Nov 30-Dec 8; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Res 2020;18(10_Suppl):Abstract nr IA26.
Misrouted cell surface receptors as a novel disease aetiology and potential therapeutic target: the case of hypogonadotropic hypogonadism due to gonadotropin-releasing hormone resistance (2003)

Molecules that are incorrectly folded or defectively assembled are recognised by cellular quality control mechanisms. This leads such conformationally abnormal molecules to intracellular retention and eventual degradation. A number of diseases caused by mutations that interfere with proper processing and intracellular trafficking of key cell surface proteins have been described. These include a particular variant of hypogonadotropic hypogonadism, which results from mislocalisation of the gonadotropin-releasing hormone (GnRH) receptor. It has been shown recently that membrane expression and function of misfolded GnRH receptor mutants can be rescued by a peptidomimetic antagonist of GnRH (IN3) that permeates into the cell and reaches the abnormally manufactured nascent receptor, stabilising a conformation compatible with cell-surface transport and reversing intracellular retention. This approach seems applicable for the development of defined therapeutic strategies for an array of diseases caused by incorrectly routed cell surface or secreted proteins.
Assessment Background of REgression (2003)

Take a test on Background of Assessment Background of REgression. The test is based on six levels of Bloom's Taxonomy
Two-phase two-stack SR motor (1998)

Keywords: Two-phase ; two-stack ; SR motor Reference EPFL-CONF-166515 Record created on 2011-06-06, modified on 2017-05-10