gebhart/patrepeval huggingface dataset:
Magenta technology multi-agent logistics i-Scheduler for road transportation (2006)

The paper describes main features of an Intelligent Scheduler for Road Transportation Applications based on Magenta agent technology and characterized by a number of unique, advanced features such as real-time, incremental, continuous scheduling and schedule improvement, scalability from small to very large enterprise networks, multi-criteria schedule analysis and rich decision support for the user, pro-active agent negotiations.The scheduler is event driven, which means that it construct schedules taking into account the occurrence of all schedule affecting events (such as the arrival of a new order, order cancellation, truck failure, road unavailability and driver no-show). As an event occurs the scheduler rapidly re-schedules only the affected part of the schedule thus causing the minimum disruption to already allocated resources.The Scheduler has been tested on real data supplied by several UK Road Logistics operators.The Scheduler was developed using protected Magenta technology for agent negotiations in virtual environment and knowledge discovery.
Micropatterned polymer surfaces improve retention of endothelial cells exposed to flow-induced shear stress (2006)

The use of synthetic polymeric vascular grafts is limited by the thrombogenecity of most biomaterials. Efforts to reduce thrombogenicity by seeding grafts with endothelial cells, the natural non-thrombogenic lining of blood vessels, have been thwarted by flow-induced cell detachment. We hypothesized that by creating well-defined micro-textured patterns on a surface, fluid flow at the surface can be altered to create discrete regions of low shear stress. We further hypothesized that, due to reduced shear stress, these regions will serve as sanctuaries for endothelial cells and promote their retention. To test these hypotheses, well-defined micro-textured polyurethane (PU) surfaces consisting of arrays of parallel 95-micron wide and 32-micron deep channels were created using an etched silicon template and solvent casting techniques. Based on computational fluid dynamics, under identical bulk flow conditions, the average local shear stress in the channels (46 dyn/cm2) was 28% lower than unpatterned surfaces (60 dyn/cm2). When PU surfaces pre-seeded with endothelial cells (EC) were exposed to the same bulk flow rate, EC retention was significantly improved on the micropatterned surfaces relative to un-patterned surfaces (92% vs. 58% retention).
ChemInform Abstract: Catalytic C—H Bond Activation—Asymmetric Olefin Coupling Reaction: The First Example of Asymmetric Fujiwara—Moritani Reaction Catalyzed by Chiral Palladium(II) Complexes. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Investigations into a power-combining structure using a reflectarray of dual-feed aperture-coupled microstrip patch antennas (2002)

This paper details an investigation of a power combiner that uses a reflectarray of dual-feed aperture-coupled microstrip patch antennas and a corporate-fed dual-polarized array as a signal distributing/combining device. In this configuration, elements of the reflectarray receive a linearly polarized wave and retransmit it with an orthogonal polarization using variable-length sections of microstrip lines connecting receive and transmit ports. By applying appropriate lengths of these delay lines, the array focuses the transmitted wave onto the feed array. The operation of the combiner is investigated for a small-size circular reflectarray for the cases of -3 dB, -6 dB and -10 dB edge illumination by the 2/spl times/2-element dual-polarized array.
ChemInform Abstract: POLYCYCLIC AND SKELETAL COMPOUNDS. IX. SYNTHESIS OF PRECURSORS OF (1,3‐DIMETHYL‐2‐CYCLOBUTEN‐1‐YL)METHYLCARBENE (1977)

Abstract Durch Isomerisierung des Cyanmethylencyclobutans (I), partielle Reduktion des entstehenden Cyanmethylcyclobutens (II) mit Li‐Hydridotriäthoxoaluminat (erhalten aus LiAlH 4 und Äthylacetat) wird der Aldehyd (III) dargestellt und auf üblichem Wege in das Tosylhydrazon (IV) übergeführt.
Abstract 354: Combination of Triiodothyronine and Dexamethasone with Flexible Matrigel Substrate Improves Structural and Electrophysiological Maturation of Human iPSC-derived Cardiomyocytes (2017)

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have promise for disease modeling and cell therapy, but electrophysiological immaturity (ie. large pacemaker currents, small I K1 ) and structural immaturity (ie. lack of t-tubules) remain major limitations. Here, we test whether the combination of triiodothyronine (T 3 ) and dexamethasone (Dex) with a soft Matrigel substrate improves hiPSC-CMs maturity. T 3 &amp; Dex or vehicle were added to cardiac induction media for 14 days. Day 30 hiPSC-CMs were plated either on hard or soft Matrigel-coated substrate for 5 days and studied using confocal imaging and voltage clamp. T 3 &amp; Dex treatment significantly increased the width and volume of hiPSC-CMs cultured on soft but not on hard substrate ( Fig.1 ). T 3 &amp; Dex treated hiPSC-CMs exhibited organized subcellular Ca release ( Fig.2 ) and evidence of t-tubule development, possibly as a result of increased Bin-1 and Caveolin-3 membrane trafficking. The combination of T 3 &amp; Dex and soft substrate increased Ca spark frequency and the amount of Ca released per spark ( Fig.3 ). T 3 &amp; Dex treatment significantly accelerated Ca transient decay under field stimulation and increased sarcoplasmic reticulum Ca-ATPase activity. Compared to vehicle, T 3 &amp; Dex treatment significantly improved electrophysiological maturity: Pacemaker current (I f ) density was 3-fold reduced (-2.7±0.35 vs. -6.2±1.3 pA/pF) and inward rectifier current (I K1 ) density was 4-fold increased (-19.3±2.2 vs. -4.4±0.5 pA/pF). Combining T 3 &amp; Dex and soft Matrigel substrate enhances structural and functional maturation of hiPSC-CMs, which will increase the utility of hiPSC-CM for disease modeling and cell therapy.
CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population (2009)

Abstract Objective The co‐occurrence of different autoimmune diseases in patients and their families suggests the presence of shared genetic risk factors. Two compelling candidate autoimmune disease susceptibility genes are those that encode CTLA4 and inducible costimulator (ICOS), immunoregulatory proteins. Associations of CTLA4 polymorphisms with various autoimmune diseases have been reported, but for rheumatoid arthritis (RA) and primary biliary cirrhosis (PBC), the association data are inconsistent and have largely excluded analysis of polymorphisms in the ICOS gene adjacent to CTLA4 . We undertook this study to examine whether CTLA4 and ICOS influence RA and PBC susceptibility by testing CTLA4/ICOS polymorphisms for association with these diseases in Canadian subjects. Methods Caucasian RA patients (n = 1,140), PBC patients (n = 481), and controls (n = 1,248) were typed for 21 biallelic polymorphisms across the CTLA4/ ICOS genes using a multiplex genotyping array, and the results were analyzed using a false discovery rate method to correct for multiple testing. Results Significant associations of multiple CTLA4 and ICOS gene polymorphisms with RA and PBC were observed, with the strongest association signals for both diseases coming from a CTLA4/ICOS intergenic single‐nucleotide polymorphism, rs17268364 (corrected P [ P corr ] = 6.0 × 10 –4 and P corr &lt; 1.0 × 10 –4 , respectively). Significant associations, which were common to both diseases, were also observed with other alleles and haplotypes across 3 linkage disequilibrium blocks within the CTLA4 gene, the intergenic region, and the ICOS gene. Conclusion Our results provide evidence for RA and PBC association with the CTLA4/ICOS locus and suggest that the risk allele(s) within this region may be common to both diseases.
Short Communications. Increased transfer ribonucleic acid methylase activity in tumours induced in the mouse colon by the administration of 1,2-dimethylhydrazine (1971)

Research Article| March 01 1971 Short Communications. Increased transfer ribonucleic acid methylase activity in tumours induced in the mouse colon by the administration of 1,2-dimethylhydrazine A E Pegg; A E Pegg Search for other works by this author on: This Site PubMed Google Scholar A Hawks A Hawks Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1971) 122 (1): 121–123. https://doi.org/10.1042/bj1220121 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation A E Pegg, A Hawks; Short Communications. Increased transfer ribonucleic acid methylase activity in tumours induced in the mouse colon by the administration of 1,2-dimethylhydrazine. Biochem J 1 March 1971; 122 (1): 121–123. doi: https://doi.org/10.1042/bj1220121 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1971 London: The Biochemical Society1971 Article PDF first page preview Close Modal You do not currently have access to this content.
Bridging the Gap for Emerging Professionals: CNHP's Professional Internship Program (2012)

The in vitro differentiation of B-lineage progenitors into Ig-secreting mature B cells has classically required a co-culture system containing lipopolysaccharide (LPS) and stromal cells. We have previously showed that B-lineage progenitors cultured in round-bottomed wells can mature and secrete immunoglobulin M (IgM) on par with cultures containing stromal cells. This clearly demonstrates that any factors essential for progenitor cell maturation can be found in cultures containing media, serum, LPS and B-cell progenitors. However, stromal cells are important for the maturation observed when cells are cultured in flat-bottomed wells. We hypothesized that stromal cells may attract B-cell progenitors and promote contacts between responsive cells, a phenomenon that is mimicked by the cultures in round-bottomed wells. In this study, we explore how stromal cells accomplish these functions. We show that stromal cells attract B-cell progenitors in a pertussis toxin-sensitive manner. The stromal cell line S17 produces the chemokine CXCL12, which is able to induce the chemotaxis of B-lineage progenitors. Chemotaxis can be blocked by a small peptide inhibitor (T134) of CXCR4, the CXCL12 receptor. Further, disrupting chemotaxis can reduce the supportive role played by S17 when B-lineage progenitors are cultured in flat-bottomed wells.
IEC-based hearing aid fitting (2003)

We propose a hearing aid fitting method based on an interactive evolutionary computation (IEC). First, we identify the problems with current hearing aid fitting methods and propose an IEC fitting method to improve the fitting process with completely different approach from that of conventional fitting methods. Then, we design an experimental hearing aid system and evaluate the IEC fitting method. Using speech and music sources, we show that our proposed IEC fitting method outperforms conventional ones.
A new device structure and process flow for a low-leakage p-i-n diode-based integrated detector array (1991)

A device structure that makes it possible to integrate a one- or two-dimensional array of p-i-n diodes (providing one- or two-dimensional spatial resolution, respectively) with readout circuitry on the same high-resistivity substrate is presented. The spatial resolution is maximized by building the circuitry on top of the detecting elements, while avoiding loss of signal charge into the circuitry. A special gettering step to obtain low leakage in the p-i-n diodes is presented as well. The specific application for which this method was developed is a particle detector for high-energy physics, but many other applications are also possible.
The Relevance of Higher Plants in Lead Compound Discovery Programs (2011)

Along with compounds from terrestrial microorganisms, the constituents of higher plants have provided a substantial number of the natural product-derived drugs used currently in Western medicine. Interest in the elucidation of new structures of the secondary metabolite constituents of plants has remained high among the natural products community over the first decade of the 21st century, particularly of species that are used in systems of traditional medicine or are utilized as botanical dietary supplements. In this review, progress made in the senior author's laboratory in research work on naturally occurring sweeteners and other taste-modifying substances and on potential anticancer agents from tropical plants will be described.
Anatomischer Erfolg der Pars-plana-Vitrektomie bei rhegmatogener Netzhautablösung im Rahmen der Umstellung von 20 auf 23 Gauge – eine Studie an 313 konsekutiven Fällen (2015)

20 G PPV as well as 23 G PPV are good surgical techniques in rhegmatogenous retinal detachment. Overall the miniaturisation of surgical instruments seems to be without any disadvantage for the surgical success.
Self‐maintained distributed tuples for field‐based coordination in dynamic networks (2005)

Abstract Field‐based coordination is a promising approach to orchestrating the activities of components in a wide range of application scenarios. To implement such an approach, one can rely on distributed tuples injected into a network and then propagated to form field‐like distributed data structures to be sensed by application components. Moreover, to gain the full benefits from such an approach, it is important to enable the distributed tuples to preserve their structures despite the dynamics of the network. In this paper, we show how a variety of self‐maintained distributed tuples for field‐based coordination can be easily programmed in the Tuples On The Air (TOTA) middleware. Several examples clarify the approach, and a case study is detailed throughout the paper to ground the discussion. Eventually, performance data are presented to verify the effectiveness of the approach. Copyright © 2005 John Wiley &amp; Sons, Ltd.
γ9δ2T cell diversity and the receptor interface with tumor cells (2020)

γ9δ2T cells play a major role in cancer immune surveillance, yet the clinical translation of their in vitro promise remains challenging. To address limitations of previous clinical attempts using expanded γ9δ2T cells, we explored the clonal diversity of γ9δ2T cell repertoires and characterized their target. We demonstrated that only a fraction of expanded γ9δ2T cells was active against cancer cells and that activity of the parental clone, or functional avidity of selected γ9δ2 T cell receptors (γ9δ2TCRs), was not associated with clonal frequency. Furthermore, we analyzed the target-receptor interface and provided a 2-receptor, 3-ligand model. We found that activation was initiated by binding of the γ9δ2TCR to BTN2A1 through the regions between CDR2 and CDR3 of the TCR γ chain and modulated by the affinity of the CDR3 region of the TCRδ chain, which was phosphoantigen independent (pAg independent) and did not depend on CD277. CD277 was secondary, serving as a mandatory coactivating ligand. We found that binding of CD277 to its putative ligand did not depend on the presence of γ9δ2TCR, did depend on usage of the intracellular CD277, created pAg-dependent proximity to BTN2A1, enhanced cell-cell conjugate formation, and stabilized the immunological synapse (IS). This process critically depended on the affinity of the γ9δ2TCR and required membrane flexibility of the γ9δ2TCR and CD277, facilitating their polarization and high-density recruitment during IS formation.
Suppression of centromere dynamics by Taxol in living osteosarcoma cells. (2003)

Taxol potently blocks mitosis at the transition from metaphase to anaphase, leading to apoptosis in many types of tumor cells. However, the precise mechanism of action of Taxol is not understood. Here we have tested the hypothesis that a primary mechanism of action of Taxol involves suppression of spindle microtubule dynamics. We have used centromere-binding protein B coupled to green fluorescent protein as a marker for the kinetochores and centromeres of chromosomes and analyzed the effects of low Taxol concentrations on the dynamics of centromeres during metaphase of mitosis in living human osteosarcoma (U2OS) cells by quantitative time-lapse confocal microscopy. In the absence of Taxol, the centromere pairs on attached sister chromatids alternately stretch apart and relax back together approximately 1.2 times/min due to tension on the kinetochores produced by the spindle microtubules (referred to here as centromere dynamics). We found that 50-100 nM Taxol significantly suppressed centromere dynamics. For example, Taxol reduced the mean separation distance between the sister centromeres from 0.73 to 0.65 microm, a distance equivalent to that observed in the complete absence of microtubules. The frequency of transitions between stretching and relaxing was also significantly diminished by Taxol (by 27%-35%). The suppressive effects of Taxol on centromere dynamics were associated with maximal accumulation of cells at mitosis (63%), a >90% block of the metaphase/anaphase transition, and complete inhibition of cell proliferation. The data strongly support the idea that the inhibition of centromere dynamics by Taxol prevents silencing of the mitotic spindle surveillance (checkpoint) mechanism. Because Taxol strongly suppresses microtubule dynamics, the data also indicate that centromere dynamics can be accounted for by microtubule dynamics and may not require significant energetic contributions from microtubule motors. The strict correlation between the degree of suppression of centromere dynamics by Taxol and the degree of mitotic block strongly indicates that the primary mechanism responsible for the mitotic block by Taxol in U2OS cells involves suppression of the polymerization dynamics of kinetochore microtubules.
Effects of Adenovirus-mediated Expression of p27 Kip1, p21 Waf1 And p16 INK4A in Cell Lines Derived from t(2;5) Anaplastic Large Cell Lymphoma and Hodgkin's Disease (2002)

We investigated the response of SUDHL-1 and L428 cells, derived from t(2;5)-anaplastic large cell lymphoma (ALCL) and Hodgkin's disease (HD), respectively, to recombinant adenoviruses expressing cyclin-dependent kinase inhibitors (CDKIs) p27Kip1 (Adp27), p21Waf1 (Adp21) and p16INK4A (Adp16). Cell cycle analysis of SUDHL-1 cells after 24 h of infection with 200 multiplicity of infection (MOI) of Adp27, Adp21, and Adp16, showed very high levels of cell debris in the subG1 area. The magnitude of cell debris-events was Adp27/Adp21 > Adp16. Cell cycle analysis of L428 cells revealed absence of cell debris and increased G2 phase in all the groups of cells tested as compared to the controls (mock and AdNull). A minimal increase in G1 phase was also evident in cells infected with Adp27 (52%) compared to uninfected cells (43%), AdNull (45%) and to cells infected with Adp21 (37%) and Adp16 (31%). The presence of significant levels of Coxsackie-adenovirus receptor (CAR) on the cell surface of L428 cells excluded the cell membrane-barrier as responsible for the differences in cell observed in response to the recombinant adenovirus-mediated CDKIs expression as compared to SUDHL-1. We also showed that the recombinant adenovirus-mediated cytotoxicity measured as apoptosis was MOI- and vector-dependent in SUDHL-1 cells at lower MOI (100). In conclusion, the therapeutic effect induced by recombinant adenoviruses expressing p27Kip1, p21Waf1 and p16INK4A is cell-dependent in cells derived from selected lymphoid malignancies. Biochemical cellular differences more than cell surface barriers seem to be responsible for differences in response to recombinant adenovirus-mediated expression of cytotoxic genes. Moreover, the cytotoxicity of recombinant adenoviruses expressing p27Kip1, p21Waf1 and p16INK4A may be further explored as a tool for gene therapy of t(2;5)-derived ALCL.
The Butter Flavorant, Diacetyl, Forms a Covalent Adduct with 2-Deoxyguanosine, Uncoils DNA, and Leads to Cell Death (2012)

Diacetyl (DA), a natural butter flavorant, is a causative agent for the lung disease obliterative bronchiolitis. Mutagenic properties of 1,2-dicarbonyls have previously been empirically linked to their possible interaction with DNA nucleobases. This study for the first time identifies chemically the adduct of DA with 2-deoxyguanosine. Selective reactivity of DA with 5'-TTTGTTTTT-3' over 5'-TTTTTTTTT-3' indicated its propensity to modify specifically the guanosine residue. Treatment of plasmid DNA, pBR322, with DA induced changes in electrophoretic mobility that are typical of ternary structure disruption. Such DNA nucleobase interaction of DA translated into increased apoptosis in DA-treated SH-SY5Y cells in a dose-dependent manner (IC(50) = 0.114 ± 0.0421 mM). The traditional carbonyl scavengers metformin, 2-thiobarbituric acid, and d-penicillamine protected cells from DA toxicity in proportion to their rates of reaction with DA, with d-penicillamine causing a maximal increase in the IC(50) to 5.23 ± 0.0992 mM when co-incubated with DA.
New Anderson‐Based Polyoxometalate Covalent Organic Frameworks as Electrodes for Energy Storage Boosted Through Keto‐Enol Tautomerization (2023)

Abstract The unique electrochemical properties of polyoxometalates (POMs) render them ideal components for the fabrication of next‐generation high‐performance energy storage systems. However, their practical applications have been hindered by their high solubility in common electrolytes. This problem can be overcome by the effective hybridization of POMs with other materials. Here we present the design and synthesis of two novel polyoxometalate‐covalent organic frameworks (POCOF) via one‐pot solvothermal strategy between an amino‐functionalized Anderson‐type POM and a trialdehyde‐based building unit. We show that structural and functional complexity can be enriched by adding hydroxyl groups in the 2,4,6 position to the benzene‐1,3,5‐tricarbaldehyde allowing to exploit for the first time in POCOFs the keto‐enol tautomerization as additional feature to impart greater chemical stability to the COFs and enhanced properties leading to large specific surface area (347 m 2 /g) and superior electrochemical performance of the POCOF‐1 electrodes, when compared with POCOF‐2 electrodes that possess only imine‐type linkage and with pristine POM electrodes. Specifically, POCOF‐1 electrodes display remarkable specific, areal, and volumetric capacitance (125 F/g, 248 mF/cm 2 and 41.9 mF/cm 3 , respectively) at a current density of 0.5 A/g, a maximum energy density (56.2 Wh/kg), a maximum power density (3.7 kW/kg) and an outstanding cyclability (90 % capacitance retention after 5000 cycles).