gebhart/patrepeval huggingface dataset:
Signs of cross-seeding: aortic medin amyloid as a trigger for protein AA deposition (2011)

The highly diverse deposition pattern displayed by systemic amyloidoses, sometimes within the same amyloid disease, remains unexplained. The localized medin (AMed) amyloidosis develops from the precursor protein lactadherin and deposits in the media of the thoracic aorta in almost all individuals above 50 years of age. Given its high prevalence in the population, and the fact that systemic amyloidoses also deposit in the aorta, led us to investigate whether AMed amyloid could influence the tissue distribution of serum amyloid A derived (AA) amyloidosis. Seven aortas from patients with diagnosed systemic AA amyloidosis were investigated. Four displayed partial co-localization between medin and AA aggregates when examined with double-labeling immunofluorescence. Furthermore, in vitro studies showed that AMed amyloid-like fibrils promote the aggregation of protein AA into fibrils. The findings indicate that the highly frequent "senile" amyloidoses may have the potential to initiate fibril formation of the more uncommon amyloidoses by a cross-seeding mechanism.
Stereoconservative Synthesis of Orthogonally Protected γ-Functionalized Amino Acids UsingN-Tritylserine Derivatives (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTStereoconservative Synthesis of Orthogonally Protected γ-Functionalized Amino Acids Using N-Tritylserine DerivativesChristophe Dugave and André MenezView Author Information CEA/Saclay, Département d'Ingénierie et d'Etude des Protéines (DIEP) Bâtiment 152, F91191 Gif-sur-Yvette, France Cite this: J. Org. Chem. 1996, 61, 17, 6067–6070Publication Date (Web):August 23, 1996Publication History Received3 April 1996Published online23 August 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo960624ghttps://doi.org/10.1021/jo960624gbrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views868Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Monomers,Peptides and proteins,Reaction products,Substitution reactions Get e-Alerts
Understanding the dramatic therapeutic play session: a contribution to pediatric nursing (2020)

the results contribute to the understanding of the conduct and analysis of the dramatic therapeutic play session, reinforcing the importance of its use in pediatric nursing care practice.
MEMS and Microfluidic Devices for Chemical and Biosensing (2019)

There has been a tremendous growth in the use of MEMS technology for physical sensing, enabled by low cost sensors and resonators for widespread use in smart phones and wearable electronic devices for health and fitness. MEMS technology is now being applied to chemical and biosensing in combination with microfluidic devices. Microfluidic devices provide integrated liquid handling for assays and cell cultures. The detection of volatile organic compounds with micro-gas chromatography is another area where miniaturization can provide lower cost and portable instruments with widespread applications. These topics are areas for technical papers presented at the upcoming IMCS meeting in Montreal in May 2020.
Substrate Specificity of α-Galactosidase fromMortierella vinacea (1990)

Journal Article Substrate Specificity of α-Galactosidase from Mortierella vinacea Get access Reiji Kaneko, Reiji Kaneko Institute of Applied Biochemistry, University of Tsukuba, Tennoodai, Tsukuba-shi, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Isao Kusakabe, Isao Kusakabe Institute of Applied Biochemistry, University of Tsukuba, Tennoodai, Tsukuba-shi, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Yosio Sakai, Yosio Sakai Institute of Applied Biochemistry, University of Tsukuba, Tennoodai, Tsukuba-shi, Ibaraki 305, Japan Present address: Kewpie Jyozo Co., Ltd., 5-19-7, Sumiyoshi-cho, Fuchu-shi, Tokyo 183, Japan. Search for other works by this author on: Oxford Academic Google Scholar Kazuo Murakami Kazuo Murakami Institute of Applied Biochemistry, University of Tsukuba, Tennoodai, Tsukuba-shi, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 54, Issue 1, 1 January 1990, Pages 237–238, https://doi.org/10.1080/00021369.1990.10869898 Published: 01 January 1990 Article history Received: 18 July 1989 Published: 01 January 1990
The domestic computer science graduate students are there, we just need to recruit them (2021)

Proven practices to recruit domestic computer science graduate students.
Highly structured homolog pairing reflects functional organization of the Drosophila genome (2018)

Abstract Trans -homolog interactions encompass potent regulatory functions, which have been studied extensively in Drosophila, where homologs are paired in somatic cells and pairing-dependent gene regulation, or transvection, is well-documented. Nevertheless, the structure of pairing and whether its functional impact is genome-wide have eluded analysis. Accordingly, we generated a diploid cell line from divergent parents and applied haplotype-resolved Hi-C, discovering that homologs pair relatively precisely genome-wide in addition to establishing trans -homolog domains and compartments. We also elucidated the structure of pairing with unprecedented detail, documenting significant variation across the genome. In particular, we characterized two forms: tight pairing, consisting of contiguous small domains, and loose pairing, consisting of single larger domains. Strikingly, active genomic regions (A-type compartments, active chromatin, expressed genes) correlated with tight pairing, suggesting that pairing has a functional role genome-wide. Finally, using RNAi and haplotype-resolved Hi-C, we show that disruption of pairing-promoting factors results in global changes in pairing. One Sentence Summary Haplotype-resolved Hi-C reveals structures of homolog pairing and global implications for gene activity in hybrid PnM cells.
Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins (2002)

Mechanical stresses modulate cell function by either activating or tuning signal transduction pathways. Mechanotransduction, the process by which cells convert mechanical stimuli into a chemical response, occurs both in cells specialized for sensing mechanical cues and in parenchymal cells whose primary function is not mechanosensory. However, common among the various responses to mechanical stress is the importance of direct or indirect connections between the internal cytoskeleton, the extracellular matrix (ECM), and traditional signal transducing molecules. In many instances, these elements converge at focal adhesions, sites of structural attachment between the cytoskeleton and ECM that are anchored by cell surface integrin receptors. Alenghat and Ingber discuss the accumulating evidence for the central role of cytoskeleton, ECM, and integrin-anchored focal adhesions in several mechanotransduction pathways.
ChemInform Abstract: Convenient One Pot Synthesis of 5‐Unsubstituted Pyrazolo[3,4‐c]isoquinolines. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Microwave-assisted synthesis of a Co3O4–graphene sheet-on-sheet nanocomposite as a superior anode material for Li-ion batteries (2010)

This paper reports the microwave-assisted synthesis of a Co3O4–graphene sheet-on-sheet nanostructure. This sheet-on-sheet nanocomposite showed an excellent high rate capability and highly reversible large capacity at common rate. A capacity of 931 mA h g−1 was observed at a large current rate of 5C (4450 mA g−1), which was still larger than the theoretical capacity of Co3O4 (890 mAh g−1). The substantially improved electrochemical properties were ascribed to the unique sheet-on-sheet nanostructure. Co3O4 nanosheets were tightly stacked with graphene nanosheets (GNS), therefore volume changes of Co3O4 materials were accommodated in the presence of GNS. On the other hand, sheet-like Co3O4 was very effective to prevent the reassembly of GNS to graphite platelets, thus preserving GNS advantages during repetitive cycling.
South Korea's Minjung Movement: The Culture and Politics of Dissidence. Edited by Kenneth M. Wells. Honolulu: University of Hawaii Press, 1995. viii, 247 pp. $35.00. (1996)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
A comparison of iterative receivers for the non linear satellite channel (2015)

This paper presents a comparison of different in- stances of advanced iterative receivers for the non linear satellite channel. A comparison of the performance and complexity of each of the selected receivers is drawn. It is shown that the frequency domain implementation of the linear equalizer achieves good performance complexity trade-off. The cost to pay for the frequency domain processing is the addition of a Cyclic Prefix (CP) to ensure the blocks orthogonality. The consequence is a channel dependent spectral efficiency loss. We thus investigate on the efficiency gain related to the CP omission for frequency domain equalizers for different block sizes and show that for large block sizes, the equalizer's performance is not much sacrificed.
Reducing the Risk of Human Space Missions With INTEGRITY (2003)

&lt;div class="htmlview paragraph"&gt;The INTEGRITY Program will design and operate a test bed facility to help prepare for future beyond-LEO missions. The purpose of INTEGRITY is to enable future missions by developing, testing, and demonstrating advanced human space systems. INTEGRITY will also implement and validate advanced management techniques including risk analysis and mitigation. One important way INTEGRITY will help enable future missions is by reducing their risk. A risk analysis of human space missions is important in defining the steps that INTEGRITY should take to mitigate risk.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper describes how a Probabilistic Risk Assessment (PRA) of human space missions will help support the planning and development of INTEGRITY to maximize its benefits to future missions. PRA is a systematic methodology to decompose the system into subsystems and components, to quantify the failure risk as a function of the design elements and their corresponding probability of failure. PRA provides a quantitative estimate of the probability of failure of the system, including an assessment and display of the degree of uncertainty surrounding the probability. PRA provides a basis for understanding the impacts of decisions that affect safety, reliability, performance, and cost. Risks with both high probability and high impact are identified as top priority. The PRA of human missions beyond Earth orbit will help indicate how the risk of future human space missions can be reduced by integrating and testing systems in INTEGRITY.&lt;/div&gt;
Photoreduction of 1,9-methanodecal-3-ones. Comparison of CIS and TRANS isomers (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoreduction of 1,9-methanodecal-3-ones. Comparison of CIS and TRANS isomersGary W. ShafferCite this: J. Org. Chem. 1973, 38, 16, 2842–2845Publication Date (Print):August 1, 1973Publication History Published online1 May 2002Published inissue 1 August 1973https://pubs.acs.org/doi/10.1021/jo00956a024https://doi.org/10.1021/jo00956a024research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ruthenium(II)‐Chitosan, an Enantioselective Catalyst for the Transfer Hydrogenation of N‐Heterocyclic Ketones (2019)

Abstract The present study aimed at extending the applicability of a recently developed stereoselective catalytic system to the preparation of optically enriched N ‐heterocyclic alcohols. Chiral ruthenium catalyst formed in situ using the chitosan biopolymer as ligand, which provided good results in the transfer hydrogenation of heterobicyclic compounds, such as 4‐chromanone and 4‐thiochromanone, was used in reactions of various N ‐containing prochiral ketones. High enantioselectivities were reached in transfer hydrogenations of bicyclic compounds bearing nitrogen either in aromatic or cycloaliphatic moieties, provided that the amino group was protected or shielded by a nearby substituent. Results were rationalized by interactions of the nitrogen with the metal and/or ligand. N ‐containing bicyclic compounds having heteroatoms in both rings were also prepared and tested. The detrimental effect of the pyridyl moiety was compensated by the beneficial influence of the heteroatom in the cycloaliphatic ring, as indicated by high rates and good enantioselectivities obtained in reactions of these compounds. Preparation of several N ‐heterocyclic alcohols, in good yields and high optical purities was achieved using Ru(II)‐chitosan complex.
Aortic pulse wave velocity, an independent marker of cardiovascular risk. (2002)

Aortic pulse wave velocity (PWV), a classical index of aortic stiffness, may be easily measured in humans using non invasive ultrasound methods of high reproducibility. Recent epidemiological studies have shown that, independently of confounding factors as age, blood pressure and cardiac mass, aortic PWV is a predictor of cardiovascular (CV) mortality in populations of hypertensive subjects, whether they have or not end-stage renal disease. Since aortic PWV is dominantly influenced by age, this finding may be of major importance for the evaluation of CV risk in geriatric populations.
Simultaneous Determination of Plasma Prednisolone, Prednisone, and Cortisol Levels by High-Performance Liquid Chromatography (2001)

Recipients of organ transplants remain particularly dependent on prednisolone as part of their maintenance immunosuppression. Despite this, the pharmacokinetics of prednisolone have never been fully characterized in these patients, and consequently dosing remains empirical. Accurate monitoring of prednisolone, its primary metabolite prednisone, and endogenous cortisol suppression in such patients may provide a means of improving the clinical outcome by adjusting for variability in prednisolone pharmacokinetics and pharmacodynamics. Measurement of endogenous cortisol may provide an independent marker of prednisolone pharmacodynamics. A simple isocratic reverse-phase high-performance liquid chromatography procedure, using betamethasone as an internal standard, was developed to quantify plasma prednisolone, prednisone, and cortisol simultaneously. The steroids were extracted from 0.5 mL plasma with 3 mL (1:1 v/v) ethyl acetate/tert-methyl butyl ether and 0.1 mL phosphoric acid, washed in 0.1 mol/L NaOH before a final drying step and reconstitution in mobile phase for injection. Separation was achieved using a Supelcosil LC-18-DB, 150 x 4.6-mm, 5-microm particle size, reverse-phase column attached to a Newguard 15 x 3-mm, RP8 guard column maintained at 25 degreesC, with ultraviolet detector set at 254 nm. The mobile phase consisted of 16% isopropanol in water containing 0.1% trifluoroacetic acid, set at a flow rate of 1.2 mL/min. The assay was linear up to 1,002 microg/L for prednisolone, 982 microg/L for prednisone, and 545 microg/L for cortisol. Mean intra-assay and interassay imprecision levels were 6.0% and 7.2%, respectively, for prednisolone, 5.8% and 7.2% for prednisone, and 5.6% and 7.9% for cortisol. Intra-assay inaccuracy was <7% of nominal values for prednisolone, prednisone, and cortisol. The lower limit of quantification was 7 microg/L for prednisolone and prednisone and 10 microg/L for cortisol. Corticosteroid recoveries were 73%, 74%, and 90% for prednisolone, prednisone, and cortisol, respectively. The authors describe a robust, inexpensive, and simple method suitable for therapeutic drug monitoring or pharmacokinetic studies of prednisolone; it may also be used to measure the suppression of endogenous cortisol production.
BCG Granuloma Appearing More Than 50 Years After Vaccination (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Proximal humerus fractures in COVID-19 lockdown: the experience of three orthopedics and traumatology departments in the first ten weeks of the Italian epidemic. (2021)

The incidence of proximal humerus fractures had a significant reduction during CoVID-19 spread. We assume that the reasons of this reduction are to be found in the national lockdown (since March 10th, 2020) and Ministerial Decrees that limited the access to the E.R. only in case of severe traumas in order to avoid CoVID-19 spread.
Amino acid and lipid profiles following pig‐to‐primate liver xenotransplantation (2018)

As outcomes in clinical liver transplantation steadily improve, demand continues to exceed supply, leading to a substantial disparity in organ availability. The translation of porcine liver xenotransplantation (LXT) into a clinical reality aims to address this dilemma. Our laboratory has previously established an applicable model of α-1,3-galactosyltransferase knockout (GalT-KO) pig-to-primate LXT with continuous human coagulation factor infusion and costimulation blockade. This report aims to further investigate the post-LXT lipid and amino acid metabolism profile in our longest surviving recipients (25 and 29 days). Experimental samples and control samples, consisting of pre-transplant porcine and baboon serum and plasma, were analyzed for standard lipid profiles and for amino acid levels. Lipid profiles of LXT recipients remained stable following xenotransplantation compared to donor porcine baseline levels. Amino acid concentrations also remained similar to baseline controls, with the exception of a 3-fold increase in l-ornithine and more than a 10-fold decrease in l-arginine post-transplant when compared to both porcine and baboon baseline levels. The observed changes in l-arginine are consistent with prior studies investigating the effects of graft preservation injury following liver transplantation. These results indicate that the porcine liver can maintain most biochemical profiles stably post-operatively in baboons and suggest that arginine supplementation post-LXT may potentially be useful for further prolongation of xenograft survival.
Multi‐objective optimal design of FLC driven hybrid mass damper for seismically excited structures (2002)

Abstract Structural vibration control using active or passive control strategy is a viable technology for enhancing structural functionality and safety against natural hazards such as strong earthquakes and high wind gusts. Both the active and passive control systems have their limitations. The passive control system has limited capability to control the structural response whereas the active control system depends on external power. The power requirement for active control of civil engineering structures is usually quite high. Thus, a hybrid control system is a viable solution to alleviate some of the limitations. In this paper a multi‐objective optimal design of a hybrid control system for seismically excited building structures has been proposed. A tuned mass damper (TMD) and an active mass driver (AMD) have been used as the passive and active control components of the hybrid control system, respectively. A fuzzy logic controller (FLC) has been used to drive the AMD as the FLC has inherent robustness and ability to handle the non‐linearities and uncertainties. The genetic algorithm has been used for the optimization of the control system. Peak acceleration and displacement responses non‐dimensionalized with respect to the uncontrolled peak acceleration and displacement responses, respectively, have been used as the two objectives of the multi‐objective optimization problem. The proposed design approach for an optimum hybrid mass damper (HMD) system, driven by FLC has been demonstrated with the help of a numerical example. It is shown that the optimum values of the design parameters of the hybrid control system can be determined without specifying the modes to be controlled. The proposed FLC driven HMD has been found to be very effective for vibration control of seismically excited buildings in comparison with the available results for the same example structure but with a different optimal absorber. Copyright © 2002 John Wiley &amp; Sons, Ltd.