gebhart/patrepeval huggingface dataset:
Load regulation of the properties of adult feline cardiocytes. The role of substrate adhesion. (1986)

We have recently described rapid and reversible changes in cardiac structure, function, and composition in response to surgical load alteration in vivo. In the present study, we used a simple, well-defined in vitro experimental model system, consisting of terminally differentiated quiescent adult cat ventricular cardiocytes maintained in serum-free culture medium, to assess more definitively the role of loading conditions in regulating these same biological properties of heart muscle. Cardiocytes considered to be externally loaded were adherent throughout their length to a protein substrate, such that the tendency for the ends of the cells to retract was prevented. Cardiocytes considered to be unloaded were not adherent to a substrate and, thus, were free to assume a spherical shape. Cardiocyte structure and surface area were assessed, in initially identified cells, both by serial light microscopy and by terminal electron microscopy. Cardiocyte function was assessed in terms of the ability to exclude trypan blue, to remain quiescent with relaxed sarcomeres containing I-bands, and to shorten in response to electrical stimulation. Cardiocyte composition was first assessed by quantitative gel electrophoresis of proteins and then by microfluorimetric measurement of ribonucleic acid, protein, and deoxyribonucleic acid. In addition, cardiocyte incorporation of [3H]thymidine into deoxyribonucleic acid and [3H]uridine into ribonucleic acid were measured. Loading via substrate adhesion was found to be very effective in terms of each of these measurements in retaining the differentiated features of adult cardiocytes for up to 2 weeks in culture; unattached and thus unloaded cardiocytes quickly dedifferentiated. Conditions thought to stimulate cardiac growth, including catecholamine stimulation, were found to be ineffective. These experiments demonstrate that external load has a primary role in the maintenance of the basic differentiated properties of adult mammalian cardiocytes.
A wireless powering system for a vibratory-actuated endoscopic capsule (2010)

The evolution of endoscopic capsules, from passive tools to robotic devices, increasingly attracts the interest of the research community. In the past few years, significant progress has been achieved in the miniaturization of electronics and electromechanical systems. However, their use in commercial endoscopic capsules is limited by their power demands, which, to present, cannot be adequately met by embedded power sources. A 3D inductive powering module, providing over 300 mW to the capsule, overcomes the power shortage that currently limits the capabilities of commercial devices, thus enabling the integration of advanced diagnostic/therapeutic features and active locomotion. This is demonstrated in the present paper by a capsule prototype employing the wireless powering unit to drive an on-board vibratory motor for capsule propulsion. Simplified models, illustrating the main principle of this vibratory locomotion scheme, are also provided. Experimental results, involving movement of the prototype over sand and liquid soap, confirm both the effectiveness of the wireless powering system, as well as the efficacy of vibratory locomotion.
LES: Locally Exploitative Sampling for Robot Path Planning (2021)

Sampling-based algorithms solve the path planning problem by generating random samples in the search-space and incrementally growing a connectivity graph or a tree. Conventionally, the sampling strategy used in these algorithms is biased towards exploration to acquire information about the search-space. In contrast, this work proposes an optimization-based procedure that generates new samples to improve the cost-to-come value of vertices in a neighborhood. The application of proposed algorithm adds an exploitative-bias to sampling and results in a faster convergence to the optimal solution compared to other state-of-the-art sampling techniques. This is demonstrated using benchmarking experiments performed fora variety of higher dimensional robotic planning tasks.
Human vitreous fibres and vitreoretinal disease. (1985)

Adult human vitreous structure was studied by dark-field Slit Microscopy in fresh, unfixed preparations of vitreous dissected off the sclera, choroid and retina. Macroscopic fibres oriented in an antero-posterior direction were detected. These fibres inserted at the vitreous base and oriented towards the macula. Significant alterations were observed in this vitreous structure with advanced age. The role of these structures in vitreo-retinal disease is discussed.
ChemInform Abstract: SYNTHETIC STUDIES OF WITHANOLIDES. I. SYNTHESIS OF 5,6β‐EPOXY‐4β‐HYDROXY‐5β‐CHOLEST‐2‐EN‐1‐ONE AND RELATED COMPOUNDS (1976)

Abstract Die Oxidation des Dienons (I) mit m‐Chlorperbenzoesäure (Cpb) ergibt ein 2:1‐Gemisch der Epoxide (IIa) und (IIb).
Background Knowledge Injection for Interpretable Sequence Classification (2020)

Sequence classification is the supervised learning task of building models that predict class labels of unseen sequences of symbols. Although accuracy is paramount, in certain scenarios interpretability is a must. Unfortunately, such trade-off is often hard to achieve since we lack human-independent interpretability metrics. We introduce a novel sequence learning algorithm, that combines (i) linear classifiers - which are known to strike a good balance between predictive power and interpretability, and (ii) background knowledge embeddings. We extend the classic subsequence feature space with groups of symbols which are generated by background knowledge injected via word or graph embeddings, and use this new feature space to learn a linear classifier. We also present a new measure to evaluate the interpretability of a set of symbolic features based on the symbol embeddings. Experiments on human activity recognition from wearables and amino acid sequence classification show that our classification approach preserves predictive power, while delivering more interpretable models.
ChemInform Abstract: MECHANISM AND SYNTHETIC UTILITY OF BORON TRIFLUORIDE ETHERATE‐PROMOTED ORGANOLITHIUM ADDITIONS (1984)

Abstract Die BF 3 ‐etherat unterstützte Alkylierung des Epoxids (I) mit den Li‐Verbindungen (II) führt in guten Ausbeuten zu den Alkoholen (III).
Le routage dans l'Internet (1995)

Au sommaire du livre : L'architecture d'Internet et le protocole IP. L'organisation du routage : RIP (vecteurs de distance), OSFP (etat des liaisons), IGRP - EGP, BGP, CIDR... - Le support des transmissions multipoints (MBONE). - Les stations mobiles. - Le support dutemps reel. - La preparation d'un successeur pour le protocole IP ?
Enabling CMOS Scaling Towards 3nm and Beyond (2018)

We look at several scaling boosters necessary to accomplish CMOS area scaling towards the 2nm node. We consider aspects of standard cell area scaling, transistor architecture, SRAM, and BEOL. We also demonstrate integrated flows and hardware feasibility for such scaling boosters.
The PIDDosome mediates delayed death of hippocampal CA1 neurons after transient global cerebral ischemia in rats (2008)

A brief period of global brain ischemia, such as that induced by cardiac arrest or cardiopulmonary bypass surgery, causes cell death in vulnerable hippocampal CA1 pyramidal neurons days after reperfusion. Although numerous factors have been suggested to account for this phenomenon, the mechanisms underlying it are poorly understood. We describe a cell death signal called the PIDDosome, a protein complex of p53-induced protein with a death domain (PIDD), receptor-interacting protein-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD), and procaspase-2. We induced 5 min of transient global cerebral ischemia (tGCI) using bilateral common carotid artery occlusion with hypotension. Western blot analysis showed that expression of twice-cleaved fragment of PIDD (PIDD-CC) increased in the cytosolic fraction of the hippocampal CA1 subregion and preceded procaspase-2 activation after tGCI. Caspase-2 cleaved Bid in brain homogenates. Co-immunoprecipitation and immunofluorescent studies demonstrated that PIDD-CC, RAIDD, and procaspase-2 were co-localized and bound directly, which indicates the formation of the PIDD death domain complex. Furthermore, we tested inhibition of PIDD expression by using small interfering RNA (siRNA) treatment that was initiated 48 h before tGCI. Administration of siRNA against PIDD decreased not only expression of PIDD-CC, but also activation of procaspase-2 and Bid, resulting in a decrease in histological neuronal damage and DNA fragmentation in the hippocampal CA1 subregion after tGCI. These results imply that PIDD plays an important role in procaspase-2 activation and delayed CA1 neuronal death after tGCI. We propose that PIDD is a hypothetical molecular target for therapy against neuronal death after tGCI.
ZEB1 induced‐upregulation of long noncoding RNA ZEB1‐AS1 facilitates the progression of triple negative breast cancer by binding with ELAVL1 to maintain the stability of ZEB1 mRNA (2020)

Triple-negative breast cancer (TNBC) is one of the malignant type of breast cancer. Previous study indicated that long noncoding RNA (lncRNA) ZEB1-AS1 was associated with the progression of several cancers. However, its underlying molecular mechanism in TNBC remains to be elucidated. In this study, ZEB1-AS1 expression was boosted in TNBC tissues and cell lines according to reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Inhibition of ZEB1-AS1 suppressed cell proliferation, migration, invasion, and promoted cell apoptosis in TNBC. Moreover, ZEB1-AS1 positively regulated ZEB1 expression. RT-qPCR disclosed ZEB1 expression was elevated in TNBC tissues and ZEB1 silence blocked TNBC progression. RNA pull-down and RNA immunoprecipitation assays revealed ZEB1-AS1 and ZEB1 both could bind with ELAVL1. ZEB1-AS1 maintained ZEB1 messenger RNA (mRNA) stability by binding with ELAVL1. In addition chromatin, immunoprecipitation and luciferase reporter assays confirmed that ZEB1 could bind with ZEB1-AS1 promoter and promoted ZEB1-AS1 expression. Rescue assays manifested ZEB1 overexpression could abolish the inhibitory effect caused by ZEB1-AS1 inhibition on TNBC progression. To sum up, ZEB1 induced-upregulation of ZEB1-AS1 maintained the stability of ZEB1 mRNA by binding with ELAVL1, which formed a feedback loop to facilitate TNBC progression. These findings might provide a new target for TNBC treatment.
EVALUATION OF (-)-CUBEBIN IN INDUCING ERECTION IN MICE (2018)

Purpose: (-)-cubebin (CUB), a dibenzylbutyrolactolic lignan, displays anti-inflammatory and antiparasitical activities. Erectile dysfunction (ED) is characterized by the persistent inability to obtain or maintain adequate penile stiffness. The aim of this study was  isolate (-)-cubebin from the dried seeds of Piper cubeba and its evaluation on erection activity. Methods: (-)-Cubebin was isolated from P. cubeba seeds by chromatographic means. Four groups of six Swiss mice each, aged 18-24 weeks, were assayed for the erectile dysfunction, as follow: negative control (saline), positive control (Tadalafil), CUB 20 mg i.p and CUB 40 mg orally. Animals of all groups were maintained under the same conditions for 4 h, after treatment for further evaluation of penile erection. The beginning latency and number of erections were observed. Afterwards, the animals were sacrificed in accordance with ethic guidelines Protocol Number: 005/09-AMB. Results and conclusion: In relation to the initiation of the erection, CUB 20 mg i.p and CUB 40 orally induced erection within 33 min and 45 min, respectively, after administration, which was faster than for the positive control group (50 min). With respect to the erection latency, CUB 20 mg, i.p., CUB 40 mg, orally, and positive control showed the same erection time (35 sec). Finally, by observing the number of erections for 30 min, both groups treated with CUB 20 mg ip and CUB 40 mg orally had more erections in 30 min (17) than the positive control (7).
Nearfield inverse scattering formalism for the three-dimensional wave equation: The inclusion of a p r i o r i velocity information (1982)

We address the problem of identifying a local velocity, c(r), in a three-dimensional scalar wave equation from nearfield data. The implicit model assumptions of previous nearfield inverse scattering procedures are examined. These assumptions cannot be reasonably assumed in certain applications. Therefore, a method for extending the range of validity of nearfield inverse scattering procedures is presented. In addition, we present a technique for incorporating a priori information or estimates into this formal wave equation inversion procedure. An approximate perturbative solution for this formalism has the ability to accommodate selective and potentially troublesome multiples within the Born model.
Strong-field plasmonic electron acceleration with few-cycle, phase-stabilized laser pulses (2011)

We carried out experimental investigations on surface plasmon enhanced electron acceleration with few-cycle, carrier-envelope phase (CEP) stabilized laser pulses. We determined the spectrum of electrons accelerated in the plasmonic field and found that signatures of the phase stabilized optical waveform driving the individual electron trajectories are washed out in the electron spectra. We attribute this effect to nanoscale surface roughness of the metallic samples, as supported by extensive numerical simulations. This finding explains the previously observed, low CEP sensitivity of photoemission processes from metallic films and enables the development of femtosecond electron sources for ultrafast time-resolved applications.
Detection and quantitation of IgG on the surface of human lymphoid cells by rosette formation with protein A‐coated sheep red blood cells (1974)

Abstract Sheep red blood cells coated with protein A of Staphylococcus aureus (SpA) form rosettes with human lymphoid cells with surface‐associated IgG and with cells treated with antibodies of the IgG class against some of the cell membrane antigens. Inhibition of rosette formation by SpA was used for quantitation of immunoglobulins on the cell surface. The sensitivity of the method permits the quantitation of 10 4 – 10 5 molecules of IgG receptors and detected less than 10 4 antibody molecules of the IgG class bound to the surface of IgM‐producing cells. This method seems to be suitable for detection and quantitation of membrane‐associated antigens including immunoglobulins.
Complications in Auditory Brainstem Implant Surgery in Adults and Children (2010)

This study demonstrates that the ABI is a safe procedure when performed by an experienced surgical and rehabilitation team, and its benefits can be extended to a larger population of deaf patients.
Effects of Child Care Center Ventilation Strategies on Volatile Organic Compounds of Indoor and Outdoor Origins (2008)

Preschool children can be at risk from harmful volatile organic compounds (VOCs) exposures in child care centers (CCCs). However, the effectiveness of ventilation for mitigating indoor VOCs exposures from myriad sources in CCCs is unclear. We investigated relationships between indoor exposures and risks of VOCs from indoor and outdoor sources under differentventilation strategies in 104 tropical CCCs. Factor analyses identified five dominant source groups of which four were associated with indoor sources, and one was associated with both indoor and outdoor sources. Indoor VOCs exposures and risks associated with indoor sources were lower in naturally (NV) and hybrid ventilated (HB) CCCs compared to air-conditioned CCCs (ACMV and AC). This is attributed to enhanced dilution via higher ventilation in NV and HB CCCs compared to ACMV and AC CCCs. Conversely, there were no discernible differences in VOCs exposures and risk associated with both indoorand outdoor sources across differentventilation strategies. The observations made in this study have implications of ventilation strategies used in other settings. To mitigate VOCs exposures and risk, it is important to identify their major indoor and outdoor sources first.
Competition between subwavelength and deep-subwavelength structures ablated by ultrashort laser pulses (2017)

Femtosecond laser-induced periodic subwavelength and deep-subwavelength structures (SWS; DSWS) have attracted attention due to their subdiffraction resolution of surface and inner volume patterning. Understanding of the richness of laser–matter interaction during formation of SWS and DSWS is another quest which can help to find control for nanoscale fabrication. Lack of control over SWS and DSWS formation has impacted their wider use and calls for a deeper insight into the relationship between them. Herein we present a systematic study defining a criterion for imprinting either SWS or DSWS, which is based on a competition and their mutual incompatibility discriminated by the laser fluence and pulse accumulation. Structure evolution of SWS and DSWS is highly dependent on the localized effective laser fluence, which determines the instantaneous optical permittivity by the laser-excited electrons creating an active plasma layer. The proposed universal SWS and DSWS competition mechanism involving the laser-induced plasma wave at the plasma-substrate interface ties together many previous observations and unifies the discussed mechanisms of surface nanoripple formation.
ChemInform Abstract: Preparation of Bis and Tris(arylimido) Complexes of Rhenium(VII), Including Bis(arylimido) Neopentylidene Complexes, Candidates as Olefin Metathesis Catalysts. (1989)

Abstract The reaction between the Re(VII) compound (I) and 3 equiv. arylisocyanates (II) in (Me 3 Si) 2 O yields the tris(arylimido) complexes (III) as the main products.
Cryogenic Solid Solubility Measurements for HFC-32 + CO2 Binary Mixtures at Temperatures Between (132 and 217) K (2023)

Abstract Accurate phase equilibrium data for mixtures of eco-friendly but mildly-flammable refrigerants with inert components like CO 2 will help the refrigeration industry safely employ working fluids with 80 % less global warming potential than those of many widely-used refrigerants. In this work, a visual high-pressure measurement setup was used to measure solid–fluid equilibrium (SFE) of HFC-32 + CO 2 binary systems at temperatures between (132 and 217) K. The experimental data show a eutectic composition of around 11 mol % CO 2 with a eutectic temperature of 131.9 K at solid–liquid–vapour (SLVE) condition. Measured SLVE and solid–liquid equilibrium data were used to tune a thermodynamic model implemented in the ThermoFAST software package by adjusting the binary interaction parameter (BIP) in the Peng–Robinson equation of state. The tuned model represents the measured melting points for binary mixtures with a root mean square deviation (RMSD) of 3.2 K, which is 60 % less than achieved with the default BIP. An RMSD of 0.5 K was obtained using the tuned model for the mixtures with CO 2 fractions over 28 mol % relative to an RMSD of 3.4 K obtained with the default model. The new property data and improved model presented in this work will help avoid solid deposition risk in cryogenic applications of the HFC-32 + CO 2 binary system and promote wider applications of more environmentally-friendly refrigerant mixtures.
Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control (2011)

Investigation from multiple groups has now focused upon HIV-specific CD8+ T-cell granule-exocytosis-mediated cytotoxicity as a correlate of immunologic control of HIV. In the near future, a more detailed understanding of the qualities associated with immunologic control may provide critical insights regarding the necessary features of a response that should be stimulated by immunotherapies or T-cell-based vaccines.
Identification and Characterization of .alpha.-Protein Kinase C Binding Proteins in Normal and Transformed REF52 Cells (1994)

Immunocytofluorescence studies demonstrated that alpha-PKC is concentrated in focal contacts of REF52 cells but not in their SV40-transformed derivatives [Jaken et al. (1989) J. Cell Biol. 109, 697-704; Hyatt & Jaken (1990) Mol. Carcinog. 3, 45-53]. Discrete localizations imply that PKC is targeted to these areas possibly via protein-protein interactions. We have used an overlay assay to detect alpha-PKC binding proteins. The molecular interactions between alpha-PKC and the binding proteins depended on phospholipid and either calcium or phorbol esters. Unlike the kinase activity, binding activity was detected in the absence of added calcium, indicating that calcium, which is necessary for phosphorylation of most substrates, is not required for binding. Vinculin and talin, two focal contact proteins, bound alpha-PKC. REF52 cells express several annexins (I, II, and VI) which bind PKC. Both annexin I expression and vinculin expression were decreased in SV40-REF52 cells. The two major REF52 cell binding proteins (p71 and p > 200 kDa) were also down-regulated in the transformed cells, indicating transformation-sensitive regulation of PKC binding protein activity.
Analyzing Power and Energy Efficiency of Bitonic Mergesort Based on Performance Evaluation (2018)

In graphics processing unit (GPU) computing community, bitonic mergesort (BM) is recognized as one of the most investigated sorting algorithms. It is specially designed for parallel architectures, requires minor inter-process communication, can be implemented in-place, and is logically appropriate for single instructions multiple data platforms. In addition, GPUs have shown tremendous improvements in power and performance efficiency and thus have become essential ingredients in pursuit of the prospective exascale systems whose major obstacle is the excessive power consumption. In a recent research work, we found that fundamental software building blocks can offer a reasonable amount of power and energy saving that can offer new ways to tackle the power obstacle of the prospective exascale systems. We evaluated average peak power, average energy, and average kernel runtime of BM under various workloads and compared it with advanced quicksort (AQ). The results showed that BM outperformed AQ based on all the three metrics in most cases. In this paper, we further investigate BM to identify the factors that result in its underlying power and energy efficiency advantage over AQ. We analyze the power and energy efficiency of BM and AQ based on their performance evaluation on NVIDIA K40 GPU. The performance of both the algorithms is investigated using various experiments offered by NVIDIA Nsight Visual Studio.
A Comparative Study of Aerosol Jet Printing on Polyimide and Liquid Crystal Polymer Substrates for RF Applications (2020)

Aerosol jet printing has been emerging as an attractive circuit fabrication technique in flexible and wearable radio frequency (RF) electronics due to the capabilities it provides beyond conventional fabrication techniques. In this paper, the effect of AJP process parameters on the printability of transmission lines on Kapton and LCP was investigated in details. Better wettability for the used ink on LCP has contributed to better line definition. The effect of sintering temperature and laser sintering power on the conductivity of transmission lines on both substrates was also studied. Employing Laser sintering has increased the conductivity significantly: 30% versus 10% of the silver bulk conductivity. However, the adhesion of the laser sintered lines on Kapton was very weak where all the lines fell off the substrate. On the other hand, the adhesion of the laser sintered lines on LCP was very good and passed multiple times of the tape test.Mircostrip lines were designed and fabricated on both substrates. The insertion loss for lines on LCP is around 0.32 dB/mm while on the Kapton samples is around 0.38 dB/mm at 40 GHz.