gebhart/patrepeval huggingface dataset:
Ultra-slow light in one-dimensional Cantor photonic crystals (2018)

Ultra-slow light and complete transmission properties in one-dimensional Cantor photonic crystals are presented. In contrast to traditional dielectric photonic crystals, the proposed structure has large group delay, slower group velocity, and a high quality factor within the same layers and materials. This study shows that larger than 1 μs group delay and slower than 1 m/s group velocity are achieved in the fifth-order Cantor photonic crystal with 52.75 μm length. This ultra-slow-light structure is very promising for application in advanced slow-light devices. A high quality factor of 10<sup>9</sup> and multiband filters with complete transmission can also be obtained by using this approach.
Speed of Pitch Change (1973)

In an attempt to determine the response characteristics of the larynx in voluntary pitch change, five adult male subjects were instructed to execute a variety of continuous pitch changes, as rapidly as possible, within the range 90–220 Hz. For a given pitch interval, there was a marked tendency for all upward pitch change to take longer than a downward pitch change. Also, unexpectedly, there was no marked tendency for a change involving a wide pitch interval to take longer than a change involving. a smaller interval. Speculations on the physiological reasons for these relations, as well as their possible relevance to the phonology of tone and intonation, will be offered. [Supported by the National Science Foundation and a University of California Faculty Research Grant.]
Proteome Integral Stability Alteration assay dramatically increases throughput and sensitivity in profiling factor-induced proteome changes (2018)

Various factors, including drugs as well as non-molecular influences, induce alterations in the stability of proteins in cell lysates, living cells and organisms. These alterations can be probed by applying a stability-modifying agent, such as elevated temperature, to a varying degree. As a second dimension of variation, drug concentration or factor intensity can be used. However, the corresponding analysis scheme has a low throughput and high cost. Additionally, since traditional data analysis employs curve fitting, proteins with unusual behavior are frequently ignored. The novel Proteome Integral Stability Alteration (PISA) assay avoids these issues altogether, increasing the analysis throughput by one to two orders of magnitude for unlimited number of parameter variation points. The consumption of the compound and biological material decreases by the same factor. We envision widespread use of the PISA approach in chemical biology and drug development.
Nonparallel Dictionary-Based Voice Conversion Using Variational Autoencoder with Modulation-Spectrum-Constrained Training (2018)

In this paper, we present a nonparallel voice conversion (VC) approach that does not require parallel data or linguistic labeling for the training process. Dictionary-based voice conversion is a class of methods aiming to decompose speech into separate factors for manipulation. Non-negative matrix factorization (NMF) is the most common method to decompose an input spectrum into a weighted linear combination of a set comprising a dictionary (basis) and weights. However, the requirement for parallel training data in this method causes several problems: 1) limited practical usability when parallel data are not available, 2) the additional error from the alignment process degrades the output speech quality. To alleviate these problems, we present a dictionary-based VC approach by incorporating a variational autoencoder (VAE) to decompose an input speech spectrum into a speaker dictionary and weights without parallel training data. According to evaluation results, the proposed method achieves better speech naturalness while retaining the same speaker similarity as NMF-based VC even though unaligned data is used.
Novel Synthesis of l-Ribose from d-Mannono-1,4-lactone (2002)

[reaction: see text] D-Mannono-1,4-lactone was efficiently converted into L-ribose in eight steps. A key step of this synthesis is the cyclization of a gamma-hydroxyalkoxamate under Mitsunobu conditions. It is noteworthy that the O-alkylation product was obtained in 94% yield and that none of the N-alkylation product was detected in this cyclization.
SARS-CoV-2 Ionophores (2020)

Raw data for SARS-CoV-2 inhibitors, polyether ionophores. Raw data includes CellTiter-Blue assay, cytopathy nuclei count and the following for morphological profiling: Full dose-response profiles and .R script to generate plots presented in the paper. plate00010_00013 is Vero E6 hTMPRSS2 cells plate00014_00017 is Vero E6 wild type cells Raw images for morphological profiling can be obtained upon request.
Development of the Ubiquitous Spaced Retrieval-Based Memory Advancement and Rehabilitation Training Program (2014)

USMART was effective in improving memory and was well tolerated by most participants with MCI, suggesting that it may be a convenient and cost-effective alternative for the cognitive rehabilitation of elderly subjects with cognitive impairments. Further studies with large numbers of participants are necessary to examine the relationship between the number of training sessions and the improvements in memory function.
Polyphenols, oxidation and colour : progress in the chemistry of enzymatic and non-enzymatic derived products (1996)

International audience
Water-Based Halon Replacement Sprays. (1996)

Abstract : Water delivered as a spray is more effective against hydrocarbon fires than a stream of water. Water as a mist is even more effective. The delivery system influences the effectiveness of water. The major problem with using water in a combat vehicle is freezing at low temperatures. Additives can be added to lower the freezing point Thus, water solutions may be usable under all expected operating conditions. Experiments have been conducted using sprays of water and water with additives to extinguish JP-8 pool fires. Additives were chosen to provide low freezing points to the water and to improve the fire extinguishing capability of the water. As expected, sprays of just water were not particularly effective for extinguishing JP-8 pool fires. Water with calcium chloride, added to give a -55 deg C freezing point, showed no improvement in fire suppression over the baseline water tests. Other additives, however, showed remarkable improvements over the water case.
Interaction between the neuromagnetic responses to sound energy onset and pitch onset suggests common generators (2004)

The pitch-onset response (POR) is a negative component of the auditory evoked field which is elicited when the temporal fine structure of a continuous noise is regularized to produce a pitch perception without altering the gross spectral characteristics of the sound. Previously, we showed that the latency of the POR is inversely related to the pitch value and its amplitude is correlated with the salience of the pitch, suggesting that the underlying generators are part of a pitch-processing network [Krumbholz, K., Patterson, R.D., Seither-Preisler, A., Lammertmann, C. & Lütkenhöner, B. (2003) Cereb. Cortex,13, 765-772]. The source of the POR was located near the medial part of Heschl's gyrus. The present study was designed to determine whether the POR originates from the same generators as the energy-onset response (EOR) represented by the N100m/P200m complex. The EOR to the onset of a noise, and the POR to a subsequent transition from noise to pitch, were recorded as the time interval between the noise onset and the transition varied from 500 to 4000 ms. The mean amplitude of the POR increased by approximately 5.9 nA.m with each doubling of the time between noise onset and transition. This suggests an interaction between the POR and the EOR, which may be based on common neural generators.
Application of t-shuffle permutation matrices in delta interconnection networks (2014)

We define some important properties of the permutation matrices of t-shuffle type which can be used to synthesize omega and inverse omega multistage interconnection networks. We also address some features of these networks compared to other networks of delta type. Finally, we propose one modification of omega network which decreases the number of stages in the network.
A hidden Markov model based approach to music segmentation and identification (2004)

Classification of musical segments is an interesting problem. It is a key technology in the development of content-based audio document indexing and retrieval. In this paper, we apply the feature extraction and modeling techniques commonly used in automatic speech recognition to solving the problem of segmentation and instrument identification of musical passages. The correlation among the different components in the feature space and the auto-correlation of each component are analyzed to demonstrate feasibility in musical signal analysis and instrument class modeling. Our experimental results are first evaluated on 3 instrument categories, i.e. vocal music, instrumental music, and their combinations. Furthermore each category is split into two individual cases to give a 6-class problem. Our results show that good performance could be obtained with simple features, such as mel-frequency cepstral coefficients and cepstral coefficients derived from linear prediction signal analysis. Even with a limited amount of training data, we could give an accuracy of 90.60% in the case of three categories. A slightly worse accuracy of 90.38% is obtained when we double the number of categories to six classes.
Dynamics of competition between incumbent and emerging network technologies (2008)

The Internet is by all accounts an incredible success, but in spite or maybe because of this success, its deficiencies have come under increasing scrutiny and triggered calls for new architectures to succeed it. Those architectures will, however, face a formidable incumbent in the Internet, and their ability to ultimately replace it is likely to depend equally on technical superiority as on economic factors. The goal of this paper is to start developing models that can help provide a quantitative understanding of a competition between the Internet and a new system, and show what factors affect it most strongly. A model for the adoption of competing network technologies by individual users is formulated and solved. It accounts for both the intrinsic value of each technology and the positive externalities derived from their respective numbers of adopters. Using this model, different configurations are explored and possible outcomes characterized. More importantly, configurations are identified where small differences in the attributes of either technology can lead to vastly different results. The paper provides initial results that can help identify parameters that significantly affect the likelihood of success of new network technologies.
Uniform protocol for wastewater UV validation applications (2013)

The treatment objective of an ultraviolet disinfection system used in a wastewater application is to protect the aquatic environment and users of water that receive discharges from wastewater treatment plants. To ensure this objective is adequately met it is important to validate, or verify equipment performance for a specific application. The widely accepted method for completing this validation is by determining the UV dose delivery performance using biodosimetry. Until now a standard bioassay did not exist for UV equipment that is used to disinfect treated wastewater from a biological treatment plant that is achieving an average effluent quality of less than 30 mg/L BOD/TSS and disinfection requirements of 126 cfu/100 mL E. coli over a 30 day geometric mean or 200 cfu/100 mL fecal coliforms over a 30 day geometric mean. A uniform bioassay for wastewater UV equipment that can be widely adopted by industry and regulatory bodies was developed and approved by the International Ultraviolet Association. This bioassay for UV equipment is described.
Towards Standard M2M APIs for Cloud-based Telco Service Platforms (2013)

Machine-to-Machine (M2M) communication technologies is emerging as one of the major trends shaping the development of services in the Future Internet sector. Additionally, cloud computing technologies have been utilized in building large-scale M2M systems, as they could potentially offer more advance solutions for managing data monitoring and service elasticity to support the needs of different consumers. Today, service providers are building a new eco-system with partner vendors to offer new innovative services for Smart Cities. From the users/applications perspective, three concepts aim to deliver Smart service: M2M communication, ubiquitous computing and ambient intelligence. In this paper we identify the requirements for centric service enablers to support the development of desired Smart Cities systems. Also the paper reviews the ongoing work in standardization organizations in this field. Providing standard interfaces to M2M platforms in a network independent way will allow applications deployment by 3rd party developers across variety of end user devices.
Scientific software production (2011)

Software plays an increasingly critical role in science, including data analysis, simulations, and managing workflows. Unlike other technologies supporting science, software can be copied and distributed at essentially no cost, potentially opening the door to unprecedented levels of sharing and collaborative innovation. Yet we do not have a clear picture of how software development for science fits into the day-to-day practice of science, or how well the methods and incentives of its production facilitate realization of this potential. We report the results of a multiple-case study of software development in three fields: high energy physics, structural biology, and microbiology. In each case, we identify a typical publication, and use qualitative methods to explore the production of the software used in the science represented by the publication. We identify several different production systems, characterized primarily by differences in incentive structures. We identify ways in which incentives are matched and mismatched with the needs of the science fields, especially with respect to collaboration.
Ehrlichia effector SLiM-icry: Artifice of cellular subversion (2023)

As an obligately intracellular bacterial pathogen that selectively infects the mononuclear phagocyte, <i>Ehrlichia chaffeensis</i> has evolved sophisticated mechanisms to subvert innate immune defenses. While the bacterium accomplishes this through a variety of mechanisms, a rapidly expanding body of evidence has revealed that <i>E. chaffeensis</i> has evolved survival strategies that are directed by the versatile, intrinsically disordered, 120 kDa tandem repeat protein (TRP120) effector. <i>E. chaffeensis</i> establishes infection by manipulating multiple evolutionarily conserved cellular signaling pathways through effector-host interactions to subvert innate immune defenses. TRP120 activates these pathways using multiple functionally distinct, repetitive, eukaryote-mimicking short linear motifs (SLiMs) located within the tandem repeat domain that have evolved <i>in nihilo</i>. Functionally, the best characterized TRP120 SLiMs mimic eukaryotic ligands (SLiM-icry) to engage pathway-specific host receptors and activate cellular signaling, thereby repurposing these pathways to promote infection. Moreover, <i>E. chaffeensis</i> TRP120 contains SLiMs that are targets of post-translational modifications such as SUMOylation in addition to many other validated SLiMs that are curated in the eukaryotic linear motif (ELM) database. This review will explore the extracellular and intracellular roles TRP120 SLiM-icry plays during infection - mediated through a variety of SLiMs - that enable <i>E. chaffeensis</i> to subvert mononuclear phagocyte innate defenses.
Relative Contribution of Central and Peripheral Aberrations to Overall High Order Corneal Wavefront Aberration (2006)

After surface ablation, ablation depth and profile significantly influence the distribution and contribution of determined combinations of high order aberrations to the overall high order corneal wavefront aberration. Terms having high angular frequency were increased following large myopic correction and wide treatment zone. Quality of the whole corneal optics will be enhanced by designing future ablation profiles to compensate for peripheral high order optical aberrations.
Cavity optomechanics with 2D photonic crystal membrane reflectors (2016)

Membranes made from silicon nitride have significantly higher mechanical Q-factors under tensile stress than those made of other dielectric materials. This makes them ideal candidates for membrane reflectors that provide high finesse in Fabry-Perot cavities or membrane-in-the-middle optomechanical systems. Building on our previous work with one-dimensional gratings on suspended membranes, we patterned two-dimensional photonic crystal gratings on monolithic, suspended membranes made from silicon nitride. These high-Q membranes exhibited high reflectivity, upwards of 99%, over several nanometers in the telecom band. To probe their optical response in a cavity environment, we used these membrane reflectors as the moving mirror in a Fabry-Perot cavity. We were able to realize cavities with a finesse of over 4,500.
Aandoeningen van ademhalingsstelsel, mediastinum en thoraxwand (2016)

Aet. Holtevorming in een ontstekingsproces dat met verettering gepaard gaat en dat o.a. ontstaat na bacteriële infecties (stafylokokken) eventueel in aansluiting op infecties met influenzavirus (grieppneumonie), bij patiënten met een geringe weerstand tegen infecties (klebsiellapneumonie), bij slechte mondhygiëne, na verslikken met aspiratie, bij verdrinking, verminderd bewustzijn, longinfarct en septische embolen, maar ook in een obstructiepneumonie achter een bronchusobstructie (bijv. bronchuscarcinoom of corpus alienum) of zonder bekende oorzaak. Geen voorkeurlokalisatie, behalve bij verslikken: dan in de dorsobasale segmenten, voornamelijk rechts.
TRP channels in brown and white adipogenesis from human progenitors: new therapeutic targets and the caveats associated with the common antibiotic, streptomycin (2017)

Transient receptor potential (TRP) channels are polymodal cell sensors responding to diverse stimuli and widely implicated in the developmental programs of numerous tissues. The evidence for an involvement of TRP family members in adipogenesis, however, is scant. We present the first comprehensive expression profile of all known 27 human TRP genes in mesenchymal progenitors cells during white or brown adipogenesis. Using positive trilineage differentiation as an exclusion criterion, TRP polycystic (P)3, and TPR melastatin (M)8 were found to be uniquely adipospecific. Knockdown of TRPP3 repressed the expression of the brown fat signature genes uncoupling protein (UCP)-1 and peroxisome proliferator-activated receptor γ coactivator (PGC)-1α as well as attenuated forskolin-stimulated uncoupled respiration. However, indices of generalized adipogenesis, such as lipid droplet morphology and fatty acid binding protein (FAPB)-4 expression, were not affected, indicating a principal mitochondrial role of TRPP3. Conversely, activating TRPM8 with menthol up-regulated UCP-1 expression and augmented uncoupled respiration predominantly in white adipocytes (browning), whereas streptomycin antagonized TRPM8-mediated calcium entry, downregulated UCP-1 expression, and mitigated uncoupled respiration; menthol was less capable of augmenting uncoupled respiration (thermogenesis) in brown adipocytes. TRPP3 and TRPM8 hence appear to be involved in the priming of mitochondria to perform uncoupled respiration downstream of adenylate cyclase. Our results also underscore the developmental caveats of using antibiotics in adipogenic studies.-Goralczyk, A., van Vijven, M., Koch, M., Badowski, C., Yassin, M. S., Toh, S.-A., Shabbir, A., Franco-Obregón, A., Raghunath, M. TRP channels in brown and white adipogenesis from human progenitors: new therapeutic targets and the caveats associated with the common antibiotic, streptomycin.
To Illustrate a Point (1992)

To Illustrate a Point Take, for example, a test tube; its long body Straightening up for science, the tight curve of its bottom Under lab lights, and the slender clarity with which It conducts itself in all matters.It knows nothing But the utmost propriety and etiquette, The need to be exact, dutiful without question, Devoted.And yet it is infinitely happy To be a test tube, flaunting simple graces, Its struggle, the feminine struggle:
Data from The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors (2023)

&lt;div&gt;Abstract&lt;p&gt;Selinexor, a selective inhibitor of nuclear export (SINE) compound targeting exportin-1, has previously been shown to inhibit melanoma cell growth &lt;i&gt;in vivo&lt;/i&gt;. We hypothesized that combining selinexor with antibodies that block or disrupt T-cell checkpoint molecule signaling would exert superior antimelanoma activity. &lt;i&gt;In vitro&lt;/i&gt;, selinexor increased &lt;i&gt;PDCD1&lt;/i&gt; and &lt;i&gt;CTLA4&lt;/i&gt; gene expression in leukocytes and induced &lt;i&gt;CD274&lt;/i&gt; gene expression in human melanoma cell lines. Mice bearing syngeneic B16F10 melanoma tumors demonstrated a significant reduction in tumor growth rate in response to the combination of selinexor and anti-PD-1 or anti-PD-L1 antibodies (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Similar results were obtained in B16F10-bearing mice treated with selinexor combined with anti-CTLA4 antibody. Immunophenotypic analysis of splenocytes by flow cytometry revealed that selinexor alone or in combination with anti-PD-L1 antibody significantly increased the frequency of both natural killer cells (&lt;i&gt;P&lt;/i&gt; ≤ 0.050) and CD4&lt;sup&gt;+&lt;/sup&gt; T cells with a Th1 phenotype (&lt;i&gt;P&lt;/i&gt; ≤ 0.050). Further experiments indicated that the antitumor effect of selinexor in combination with anti-PD-1 therapy persisted under an alternative dosing schedule but was lost when selinexor was administered daily. These data indicate that the efficacy of selinexor against melanoma may be enhanced by disrupting immune checkpoint activity. &lt;i&gt;Mol Cancer Ther; 16(3); 417–27. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;i&gt;See related article by Tyler et al., p. 428&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
UTILIZATION OF ALUMINA RED MUD FOR SYNTHESIS OF INORGANIC POLYMERIC MATERIALS (2009)

Red mud is a residue coming from the metallurgical treatment of bauxite with the Bayer process. Million of tons of red mud are produced annually worldwide and disposed of on land, degrading vast areas. Therefore, red mud utilization is a first-priority issue for any alumina plant. In the present work, the potential use of red mud for synthesis of inorganic polymeric materials through geopolymerization process was studied. The main focus was the production of inorganic polymeric materials that could be used in the construction sector as artificial structural elements such as massive bricks. The geopolymerization process involves a chemical reaction between red mud and alkali metal silicate solution under highly alkaline conditions. The product of this reaction is an amorphous to semi-crystalline polymeric structure, which binds the individual particles of red mud transforming the initial granular material to a compact and strong one. The effect of main synthesis parameters—like solid-to-liquid ratio, caustic soda as well as soluble silica concentrations, and metakaolin addition—on the properties of red mud-based inorganic polymeric materials was investigated. The results showed that the produced materials have high compressive strength, very low water absorption, satisfactory apparent density, and excellent fire resistance. Therefore, this work proved that the red mud-based inorganic polymeric materials have promising properties and have the potential to be used as artificial structural elements in the construction sector.