gebhart/patrepeval huggingface dataset:
Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways (2010)

A subgroup of head and neck squamous cell carcinomas (HNSCCs) contains high-risk human papillomavirus-type 16 (HPV16). The viral E6 and E7 oncoproteins inactivate the p53 and pRb proteins, respectively. We examined the causative effect of HPV16 E6 and E7 expression on the immortalization of normal oral keratinocytes (OKCs) and compared the resulting phenotype with alternative ways of p53- and pRb-pathway abrogation frequently found in HNSCCs without HPV. Primary OKCs were conditionally immortalized with temperature-sensitive SV40 large T-antigen and human telomerase, allowing these cells to return to their senescent primary state after temperature shift. HPV16 E6 and E7 were introduced to overcome senescence, determined with population doubling (PD) as read-out. For comparison, we downregulated p53 and p16 by short hairpin RNA genes and expressed mutant p53R(175)H and cyclinD1. Expression of HPV16 E6 caused an extended life span similar to expression of mutant p53R(175)H or p53 knockdown. Expression of mutant p53R(175)H seemed to cause additional activation of the hypoxia and WNT signaling pathways. HPV16 E7 expression had no direct effect on lifespan, similar to p16 knockdown or cyclinD1 expression. In combination with HPV16 E6 or other functional inactivations of p53, abrogation of the pRb-pathway by either HPV16 E7 or other manipulations caused an immortal phenotype. Our data show the causative role of HPV16 E6/E7 in early squamous carcinogenesis. Activity of each gene could be mimicked by other genetic events frequently found in HNSCC without HPV. This data provides the experimental proof of causal association of HPV in HNSCC carcinogenesis and further support the crucial role of the p53- and pRb-pathways.
Preparation and properties of poly(quinolinediyl)s and poly(isoquinoline-1,4-diyl) with new π-conjugation systems (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and properties of poly(quinolinediyl)s and poly(isoquinoline-1,4-diyl) with new π-conjugation systemsTakaki Kanbara, Nobuo Saito, Takakazu Yamamoto, and Kenji KubotaCite this: Macromolecules 1991, 24, 21, 5883–5885Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/ma00021a027https://doi.org/10.1021/ma00021a027research-articleACS PublicationsRequest reuse permissionsArticle Views457Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tutorial database mining (1994)

We view database mining as the efficient construction and verification of models of patterns embedded in large databases. Many of the database mining problems have been motivated by the practical decision support problems faced by most large retail organizations. In the Quest project at the IBM Almaden Research center, we have focussed on three classes of database mining problems involving classification, associations, and sequences. In this tutorial, I will draw upon my Quest experience to present my perspective of database mining, describe current work, and present some open problems.
ESR1 and EGFgenetic variation in relation to breast cancer risk and survival (2008)

Our results do not support a strong association between common variants in the ESR1 and EGF genes and breast cancer risk, tumour characteristics or survival.
WillSense (2017)

Energy balance is one component of weight management, but passive objective measures of caloric intake are non-existent. Given recent success of actigraphy as a passive objective measure of the physical activity construct that relieves participants of the burden of biased self-report, researchers are aiming to find a passive objective measure of caloric intake to improve understanding of problematic eating behaviors in obese and non-obese participants. Passive sensing food intake systems have failed to go beyond the lab and into behavioral research in part due to low adherence to wearing passive monitoring systems. This paper presents preliminary results in obese and non-obese participants performing structured and unstructured eating experiments to understand wearable adherence as affected by: 1) perceived data privacy; 2) stigma of wearing devices; 3) comfort. Wearables examined include neck- and wrist-worn sensors, and video camera-based systems.
Optimized Standard Cells for All-Spin Logic (2016)

All-Spin Logic (ASL) devices provide a promising spintronics-based alternative for Boolean logic implementations in the post-Complementary Metal-Oxide Semiconductor (CMOS) era. In principle, any logic functionality can be implemented in ASL. In practice, the performance of an ASL gate is significantly affected by layout choices, but such implications have not been adequately explored in the past. This article proposes a systematic approach for building standard cells in ASL, which are a basic building block in an overall design methodology for implementing large ASL-based circuits. We first propose a new technique to reduce the magnet count for an ASL majority gate but still ensure correct functioning through layout optimization methods. Building on physics-based analysis, we then build a standard cell library with diverse functionality and characterize the library for delay, energy, and area. We perform delay-optimized technology mapping on ISCAS85 benchmark circuits using our library. Our approach results in circuits that are 12.90% faster, consume 26.16% less energy, and are 33.56% more area efficient compared to a standard cell library that does not incorporate layout-based optimization techniques of our work.
Long-Term Area Coverage and Radio Relay Positioning Using Swarms of UAVs (2019)

Unmanned Aerial Vehicles (UAVs) are becoming increasingly useful for tasks that require the acquisition of data over large areas. Online coverage algorithms obviously pose a greater challenge to ensure efficient operations with multiple UAVs compared to offline ones. Optimal relay positioning is a widely explored problem in the telecommunication field, where it is used to place antennas in a given area to provide robust wireless connection. The chapter presents the experiments used to assess the performance of the simultaneous coverage and relay-positioning algorithm and the related architecture. It proposes a novel approach to improve the performance of a UAVs swarm tasked to cover a given area in difficult contexts such as natural disasters. Future developments will deal with further increasing the robustness of the proposed architecture by exploring in detail the best strategies to adopt when multiple UAVs are busy with secondary tasks or to avoid the chain to be interrupted.
Ultrathin Fiberscope Utilizing A Single Channel for both Illumination and Imaging (2005)

An ultrathin fiberscope has been developed that incorporates broadband illumination and imaging within a single 0.5 mm coherent fiber bundle by allotting a portion of the numerical aperture to illumination.
Proximal humeral fractures: internal fixation. (2012)

Fractures of the proximal humerus are common injuries that are increasing in incidence as the population ages. These fractures are often treated nonsurgically; however, surgery is indicated if displacement, concurrent dislocation, or unacceptable alignment is present. Knowledge of the anatomic and physiologic characteristics of the proximal humerus and shoulder joint and familiarity with the available fixation elements will help surgeons make informed and patient-specific decisions regarding treatment. Reduction and internal fixation of proximal humeral fractures has expanding indications in comparison with arthroplasty, in part because of improvements in fixation technology and a better understanding of anatomy and physiology. The outcomes of proximal humeral fractures managed with percutaneous pinning, open reduction and locked-plate fixation, and intramedullary fixation are being actively investigated.
Pyrolysis and subsequent steam gasification of metal dry impregnated lignin for the production of H2-rich syngas and magnetic activated carbon (2020)

An integrated process that includes the pyrolysis of FeSO4 dry impregnated lignin and subsequent steam gasification of the produced biochar has been performed to produce H2-rich syngas and magnetic activated carbon. The results show that gasification is more beneficial for hydrogen production than pyrolysis. Increasing the pyrolysis temperature from 550 °C to 800 °C and iron loading from 4% to 8% not only promotes the extension decomposition of lignin but also induces the production of char, which is more effective for gasification. As a result, the syngas yield and H2 volumetric percentage of both the pyrolysis and steam gasification processes are enhanced. The maximum overall H2 yield and exergy efficiency for producing H2 are estimated to be 42.73 mol/kg-lignin and 46.63%, respectively. Magnetic activated carbon materials produced from the proposed integrated process have a good porous property and high saturation magnetization value. Magnetic activated carbon that is produced from the same process that achieves a maximum H2 yield is obtained and exhibits an approximate 70% total phosphate and 20% ammonia and nitrogen removal efficiency for treating real domestic wastewater.
Pyridine as proton acceptor in the concerted proton electron transfer oxidation of phenol (2011)

Taking pyridine as a prototypal example of biologically important nitrogen bases involved in proton-coupled electron transfers, it is shown with the example of the photochemically triggered oxidation of phenol by Ru(III)(bpy)(3) that this proton acceptor partakes in a concerted pathway whose kinetic characteristics can be extracted from the overall kinetic response. The treatment of these data, implemented by the results of a parallel study carried out in heavy water, allowed the determination of the intrinsic kinetic characteristics of this proton acceptor. Comparison of the reorganization energies and of the pre-exponential factors previously derived for hydrogen phosphate and water (in water) as proton acceptors suggests that, in the case of pyridine, the proton charge is delocalized over a primary shell of water molecules firmly bound to the pyridinium cation.
1.6-Tbit/s Muxing, Transmission and Demuxing through 1.1-km of Vortex Fiber Carrying 2 OAM Beams Each with 10 Wavelength Channels (2013)

We demonstrate muxing, transmission and demuxing of 2 OAM beams over 10 wavelength channels through 1.1-km of vortex fiber. An aggregated total capacity of 1.6-Tbit/s is achieved by using 20-Gbaud/s 16-QAM signal on each channel.
Rice LTG1 is involved in adaptive growth and fitness under low ambient temperature (2014)

Low temperature (LT) is one of the most prevalent factors limiting the productivity and geographical distribution of rice (Oryza sativa L.). Although significant progress has been made in elucidating the effect of LT on seed germination and reproductive development in rice, the genetic component affecting vegetative growth under LT remains poorly understood. Here, we report that rice cultivars harboring the dominant LTG1 (Low Temperature Growth 1) allele are more tolerant to LT (15-25°C, a temperature range prevalent in high-altitude, temperate zones and high-latitude areas), than those with the ltg1 allele. Using a map-based cloning strategy, we show that LTG1 encodes a casein kinase I. A functional nucleotide polymorphism was identified in the coding region of LTG1, causing a single amino acid substitution (I357K) that is associated with the growth rate, heading date and yield of rice plants grown at LT. We present evidence that LTG1 affects rice growth at LT via an auxin-dependent process(es). Furthermore, phylogenetic analysis of this locus suggests that the ltg1 haplotype arose before the domestication of rice in tropical climates. Together, our data demonstrate that LTG1 plays an important role in the adaptive growth and fitness of rice cultivars under conditions of low ambient temperature.
Distributed Denial of Service (DDoS) Open Threat Signaling Requirements (2019)

This document defines the requirements for the Distributed Denial of
Service (DDoS) Open Threat Signaling (DOTS) protocols enabling
coordinated response to DDoS attacks.
Effects of Breastfeeding on Endometriosis-Related Pain: A Prospective Observational Study (2021)

Endometriosis is a gynecological estrogen-dependent disease whose commonest pain symptoms are dysmenorrhea, dyspareunia, and acyclic chronic pelvic pain (CPP). Hormonal changes occurring during breastfeeding seem to reduce pain and disease recurrence. The aim of this observational prospective study was to assess the effect of breastfeeding on pain and endometriotic lesions in patients with endometriosis and to evaluate a possible correlation between the duration of breastfeeding, postpartum amenorrhea, and pain. Out of 156 pregnant women with endometriosis enrolled, 123 who breastfed were included in the study and were monitored for 2 years after delivery; 96/123 exclusively breastfed for at least 1 month. Mode of delivery, type and duration of breastfeeding, intensity of pain symptoms, and lesion size before pregnancy and during the 24-month follow-up were analyzed. All patients experienced a significant reduction in dysmenorrhea proportional to the duration of breastfeeding. CPP was significantly reduced only in women who exclusively breastfed. No significant improvement in dyspareunia was observed. Ovarian endometriomas were significantly reduced. Therefore, breastfeeding, particularly if exclusive, may cause improvement in dysmenorrhea and CPP proportional to the duration of breastfeeding, as well as a reduction in the size of ovarian endometriomas.
Comparison of Simultaneous Measurements of Blood Pressure by Tail-Cuff and Carotid Arterial Methods in Conscious Spontaneously Hypertensive and Wistar-Kyoto Rats (2006)

We determined the validity of systolic blood pressure (SBP) measured by tail-cuff blood pressure (TCBP) with direct intra-arterial measurements. In conscious, restrained Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR), carotid artery (CA) BP and TCBP were simultaneously measured. In both WKY and SHR strains, highly significant correlations between CABP and TCBP were found and Bland-Altman analyses showed no bias when the two methods were compared. The limits of agreement between CABP and TCBP in WKY and SHR were wide and reproducibility of pressure measurements by either technique was poor, with some evidence for strain-dependent differences. Pressure measurements made over short time frames, however, showed close agreement between CABP and TCBP. Acetylcholine-induced reductions in pressure were equivalently detected by tail-cuff and direct arterial measurement in both strains but angiotensin II-induced pressure elevations were over-estimated by tail-cuff in SHR. Telemetered SBP measurements in conscious rats were highly variable in a strain-dependent manner.
Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK (2017)

Small molecules targeting aberrant RAF activity, like vemurafenib (PLX4032), are highly effective against cancers harboring the V600E BRAF mutation and are now approved for clinical use against metastatic melanoma. However, in tissues showing elevated RAS activity and in RAS mutant tumors, these inhibitors stimulate RAF dimerization, resulting in inhibitor resistance and downstream "paradoxical" ERK activation. To understand the global signaling response of cancer cells to RAF inhibitors, we profiled the temporal changes of the phosphoproteome of two colon cancer cell lines (Colo205 and HCT116) that respond differently to vemurafenib. Comprehensive data mining and filtering identified a total of 37,910 phosphorylation sites, 660 of which were dynamically modulated upon treatment with vemurafenib. We established that 83% of these dynamic phosphorylation sites were modulated in accordance with the phospho-ERK profile of the two cell lines. Accordingly, kinase substrate prediction algorithms linked most of these dynamic sites to direct ERK1/2-mediated phosphorylation, supporting a low off-target rate for vemurafenib. Functional classification of target proteins indicated the enrichment of known (nuclear pore, transcription factors, and RAS-RTK signaling) and novel (Rho GTPases signaling and actin cytoskeleton) ERK-controlled functions. Our phosphoproteomic data combined with experimental validation established novel dynamic connections between ERK signaling and the transcriptional regulators TEAD3 (Hippo pathway), MKL1, and MKL2 (Rho serum-response elements pathway). We also confirm that an ERK-docking site found in MKL1 is directly antagonized by overlapping actin binding, defining a novel mechanism of actin-modulated phosphorylation. Altogether, time-resolved phosphoproteomics further documented vemurafenib selectivity and identified novel ERK downstream substrates.
Collaborative Learning for Weakly Supervised Object Detection (2018)

Weakly supervised object detection has recently received much attention, since it only requires image-level labels instead of the bounding-box labels consumed in strongly supervised learning. Nevertheless, the save in labeling expense is usually at the cost of model accuracy. In this paper, we propose a simple but effective weakly supervised collaborative learning framework to resolve this problem, which trains a weakly supervised learner and a strongly supervised learner jointly by enforcing partial feature sharing and prediction consistency. For object detection, taking WSDDN-like architecture as weakly supervised detector sub-network and Faster-RCNN-like architecture as strongly supervised detector sub-network, we propose an end-to-end Weakly Supervised Collaborative Detection Network. As there is no strong supervision available to train the Faster-RCNN-like sub-network, a new prediction consistency loss is defined to enforce consistency of predictions between the two sub-networks as well as within the Faster-RCNN-like sub-networks. At the same time, the two detectors are designed to partially share features to further guarantee the model consistency at perceptual level. Extensive experiments on PASCAL VOC 2007 and 2012 data sets have demonstrated the effectiveness of the proposed framework.
Game theory and iterated Voronoi diagrams for self-organized Wireless Sensor Networks (2011)

Wireless Sensor Networks (WSNs) have become an attractive technology to support various applications. In many situations, the region where the sensor nodes are deployed needs to be uniformly covered. This paper proposes a new technique to implement self-organization strategies for WSNs. We show that the process of iterating the computation of the Voronoi diagram generated by the sensors has a maximum fixed point which corresponds to the Nash equilibrium of a strategic game where sensor nodes move iteratively to the centers of the Voronoi cells. We have shown that this fixed-point represents the best deployment that can be achieved, from the coverage point of view. We also performed a set of experiments to show that the proposed technique outperform the existing approaches.
Critical aneurysmal dilatation of the thoracic aorta in young adolescents with variant hyperimmunoglobulin E syndrome (2006)

The autosomal-dominant (AD) form of the hyperimmunoglobulin E syndrome (HIES) has been described as a multisystem disorder including immune, skeletal and dental abnormalities. Recently, the evaluation of patients from families in which HIES was inherited in a manner more consistent with autosomal-recessive (AR) inheritance, showed that AR-HIES is a clinically distinct disease entity. In addition to classical immunologic findings of AD-HIES, the AR form presents with severe recurrent fungal and viral infections with herpes zoster, herpes simplex and characteristic mollusca contagiosa. Furthermore, cerebral vascular sequelae, including vasculitis, infarction and haemorrhage were noted. In this report, we describe the clinical picture of two patients who showed remarkable resemblance to the description of AR-HIES, but also developed fatal aneurysmal dilatation of the thoracic aorta in adolescence. This finding may further consummate the clinical picture of AR-HIES and emphasize the possibility to develop early aortitis, most likely preceding the critical aneurysm formation at older age. This process should be anticipated during childhood in cases with AR-HIES.
Phytochemical and pharmacological aspects of Nothapodytes nimmoniana. An overview (2013)

Summary Nothapodytes nimmoniana (J. Graham) (Icacinaceae), commonly known as Amruta is found in India particularly in Maharashtra, Goa, Kerala, Assam, Jammu and Kashmir as well as Tamilnadu areas. It is an important medicinal plant, the major source of a potent alkaloid, namely camptothecin, of a wide spectrum of pharmacological activities like anti-cancer, anti-HIV, antimalarial, antibacterial, anti-oxidant, anti-inflammatory, anti-fungal and also applied in the treatment of anaemia. Camptothecin is still not synthesized, therefore, its production entirely depends on natural sources. N. nimmoniana is one such plant which yields contain camptothecin in significantly high amount. The plant is gaining international recognition due to its diversified medicinal uses. It is subjected to excessive harvest. It has been categorized as a vulnerable and endangered plant. The present review encompasses the phytochemical, analytical, pharmacological, biotechnological, and other specific aspects of N. nimmoniana.
Stress‐Actuated Spiral Microelectrode for High‐Performance Lithium‐Ion Microbatteries (2020)

Miniaturization of batteries lags behind the success of modern electronic devices. Neither the device volume nor the energy density of microbatteries meets the requirement of microscale electronic devices. The main limitation for pushing the energy density of microbatteries arises from the low mass loading of active materials. However, merely pushing the mass loading through increased electrode thickness is accompanied by the long charge transfer pathway and inferior mechanical properties for long-term operation. Here, a new spiral microelectrode upon stress-actuation accomplishes high mass loading but short charge transfer pathways. At a small footprint area of around 1 mm<sup>2</sup> , a 21-fold increase of the mass loading is achieved while featuring fast charge transfer at the nanoscale. The spiral microelectrode delivers a maximum area capacity of 1053 µAh cm<sup>-2</sup> with a retention of 67% over 50 cycles. Moreover, the energy density of the cylinder microbattery using the spiral microelectrode as the anode reaches 12.6 mWh cm<sup>-3</sup> at an ultrasmall volume of 3 mm<sup>3</sup> . In terms of the device volume and energy density, the cylinder microbattery outperforms most of the current microbattery technologies, and hence provides a new strategy to develop high-performance microbatteries that can be integrated with miniaturized electronic devices.