gebhart/patrepeval huggingface dataset:
Pretranscriptional Regulation of Tgf-β1 by PI Polyamide Prevents Scarring and Accelerates Wound Healing of the Cornea After Exposure to Alkali (2009)

Corneal alkali burns are a serious clinical problem that often leads to permanent visual impairment. In this process, transforming growth factor (Tgf)-beta1 is upregulated and involved in the response to corneal injury and the process of corneal stromal scarring. To develop an efficient compound to inhibit Tgf-beta1 in the cornea, we designed GB1201, a pyrrole-imidazole (PI) polyamide targeting rat Tgf-beta1 gene promoter to the activator protein-1 (AP-1) binding site. GB1201 showed a high binding affinity to the target DNA sequence in the gel mobility shift and Biacore assays. GB1201 significantly inhibited the rat Tgf-beta1 gene promoter activity in HEK (human embryonic kidney) 293 cells in a concentration-dependent manner. Topically administrated GB1201 was distributed immediately to the nuclei of all cell layers of the cornea and remained for 24 hours. A corneal alkali burn model in rats was used to evaluate the therapeutic efficacy of GB1201. GB1201 suppressed the upregulation of Tgf-beta1 in the burned cornea, both in the mRNA and protein levels. Moreover, daily treatment with GB1201 for a week significantly improved the corneal tissue wound healing, reduced corneal stromal scarring, and prevented corneal haze formation. Our data suggest that PI polyamide may open new opportunities for therapeutic intervention in the treatment of chemically burned corneas.
Feasibility study on the use of in vivo microCT to follow up ectopic 3D mineralized tissue formation (2014)

status: Published
Spin Torque Efficiency and Analytic Error Rate Estimates of Skyrmion\n Racetrack Memory (2017)

In this paper the thermal stability of skyrmion bubbles and the critical\ncurrents to move them over pinning sites is investigated. For the used pinning\ngeometries and the used parameters, the unexpected behavior is reported that\nthe energy barrier to overcome the pinning site is larger than the energy\nbarrier of the annihilation of a skyrmion. The annihilation takes place at\nboundaries by current driven motion as well as due to the excitation over\nenergy barriers, in the absence of currents, without forming Bloch points. It\nis reported that the pinning sites, which are required to allow thermally\nstable bits, significantly increase the critical current densities to move the\nbits in skyrmion like structures to about $j_{crit}$ = 0.62 TA/m$^2$. These\ncurrents are similar to those obtained experimentally to move stable skyrmions\nat room temperature. By calculating the thermal stability as well as the\ncritical current, we can derive the spin torque efficiency $\\eta$ = $\\Delta/I_c\n= 0.19 k_BT_{300}~/\\mu$A, which is in a similar range to the simulated spin\ntorque efficiency of MRAM structures. Finally, it is shown that the stochastic\ndepinning process of any racetrack like device requires extremely narrow\ndepinning time distribution smaller than ~6% of the current pulse length to\nreach bit error rates smaller than ${10^{ - 9}}$.\n
Mediation of Electron Transfer by Quadrupolar Interactions: The Constitutional, Electronic, and Energetic Complementarities in Supramolecular Chemistry (2019)

Studies of intermolecular interactions enhance our knowledge of chemistry across molecular and supramolecular levels. Here, we show that host-guest quadrupolar interaction has a profound influence on the molecular system. With covalently bonded dimolybdenum complex units as the electron donor (D) and acceptor (A) and a thienylene group (C<sub>4</sub>H<sub>2</sub>S) as the bridge (B), the mixed-valence D-B-A complexes are shaped with clefts in the middle of the molecule. Interestingly, in aromatic solvents, the D-A electronic coupling constants (H<sub>ab</sub>) and electron transfer rates (k<sub>et</sub>) are dramatically reduced. Theoretical computations indicate that an aromatic molecule is encapsulated in the cleft of the D-B-A array; quadrupole-quadrupole interaction between the guest molecule and the C<sub>4</sub>H<sub>2</sub>S bridge evokes a charge redistribution, which increases the HOMO-LUMO energy gap, intervening in the through-bond electron transfer. These results demonstrate that a supramolecular system is unified underlying the characteristics of the assembled molecules through constitutional, electronic, and energetic complementarities.
Neutral gas filled transport cells for high current electron beams (1990)

Summary form only given. A series of experiments is being conducted with a passive electron beam transport and centering system consisting of a conducting tube filled with neutral gas. The object is to study the transport and centering properties of the cell as a function of input beam current, transport cell length, cell diameter, fill pressure, and fill gas type. The electron beam is generated by the US Naval Research Laboratory's SuperIBEX accelerator, which produces a 5.0-MeV, 50-kA, 40-ns FWHM (full width at half maximum) electron beam. The electron beam diode consists of a 6-mm-diameter cold cathode and a 0.5-mil-thick titanium foil anode. The injected beams are <2.0 cm in diameter and have low divergence (<50 mrad). The experiments cover a wide range of parameters. The beam current is varied from 10 to 40 kA, the pressure from 0 to 100 mtorr, the transport length from 40 to 120 cm, and the cell diameter from 5 to 10 cm, and several gases (Ar, He) are used to examine the effects of ionization potential. The results of the experiments have been compared to computer simulations of SuperIBEX beams in the gas-filled transport cells
Noise Reduction Technology for F/A-18 E/F Aircraft (2004)

This paper summarizes both experimental and computational research associated with efforts to produce aeroperformance efficient solutions for the reduction of noise for the F/A-18 E/F aircraft undergoing the Field Carrier Landing Practice (FCLP) mission. Acoustic measurements of baseline and suppressed 1/10’th scale model nozzle configurations at actual engine operating conditions are reported. The model studies have been conducted along the engine cycle lines for the GEAE F414-400, F404-402, and F404-400 engines in preparation for full-scale aeroperformance and acoustic evaluation of the F404-400 engine at the Naval Air Warfare Center Aircraft Division in Lakehurst, N.J. The noise suppression concepts investigated are those that can be implemented with simple modifications to existing jet engine nozzle parts. These involve the following performance efficient concepts: corrugated internal divergent secondary flap seals and external divergent primary flap chevrons. Experimental measurements have indicated that at Military power, corrugated seals suppress noise by 4 dB relative to the baseline and 2 dB by chevrons. The results with corrugated seals also showed significant reduction in plume Infrared emission. Model-scale computations indicate that all concepts reduce the jet flow turbulent kinetic energy. Based on these predictions and the JET3D code of NASA LaRC, it is shown that the turbulent exhaust flow with suppression concept deployed leads to reduction of noise with minimal performance penalty. The predictions actually show performance enhancement when internal corrugations are utilized.
Indium‐2,4,6‐tris(trifluormethyl)phenoxid – ein Dimer mit der Koordinationszahl zwei an den Indiumatomen (1989)

Niederkoordinierte Verbindungen von Elementen der Borgruppe des Periodensystems sind ein faszinierendes Forschungsgebiet. Die Titelverbindung 1 ist das erste Beispiel einer Indium(I)‐Verbindung mit zweifach koordinierten Indiumatomen. Der sterisch anspruchsvolle, elektronenziehende Ligand dürfte auch andere Elemente in niedrigen Oxidationsstufen stabilisieren. magnified image
Robust Image Description with Weighted and Adaptive Local Binary Pattern Features (2014)

The Local Binary Pattern (LBP) is an effective image descriptor. However, this descriptor has limitations in some of challenging issues in texture analysis, such as invariance to scaling, rotation, viewpoint variations and non-rigid deformations. In order to overcome these demerits of LBP, the paper proposed a weighted and adaptive LBP-based texture descriptor. Adaptive definition of circular neighboring set in LBP descriptor is very effective to achieve scale invariance features [1]. In our proposed method, both circular neighboring radius and orientation of sampling in LBP descriptor are defined in an adaptive manner. We used the radius of blob-like structures to determine the radius of sampling, similar to [1]. Definition of LBP operator with respect to dominant orientation of each pixel can guarantee the rotation invariance of LBP features. The original LBP operator discards the magnitude information of the difference between the center and the neighbor gray values in a local neighborhood. Therefore, the paper also proposes weighted LBP features as a simple and efficient method to incorporate this information into the LBP histograms. We report extensive experiments comparing the proposed method to seven LBP-based descriptors, in texture retrieval and classification on two databases: Brodatz and UIUC. The experimental results show that the proposed Weighted-, Rotation- and Scale-Invariant Local Binary Pattern (WRSI_LBP) operator can achieve significant improvement in texture retrieval and classification over other LBP-based methods.
Waste management technology development and demonstration programs at Brookhaven National Laboratory (1991)

Two thermoplastic processes for improved treatment of radioactive, hazardous, and mixed wastes were developed from bench scale through technology demonstration: polyethylene encapsulation and modified sulfur cement encapsulation. The steps required to bring technologies from the research and development stage through full scale implementation are described. Both systems result in durable waste forms that meet current Nuclear Regulatory Commission and Environmental Protection Agency regulatory criteria and provide significant improvements over conventional solidification systems such as hydraulic cement. For example, the polyethylene process can encapsulate up to 70 wt pct. nitrate salt, compared with a maximum of about 20 wt pct. for the best hydraulic cement formulation. Modified sulfur cement waste forms containing as much as 43 wt pct. incinerator fly ash were formulated, whereas the maximum quantity of this waste in hydraulic cement is 16 wt pct.
2D Perovskite Nanosheets with Thermally-Stable High-κ Response: A New Platform for High-Temperature Capacitors (2014)

We investigated high-temperature dielectric responses of high-κ perovskite nanosheet (Ca2Nb3O10), an important material platform for postgraphene technology and ultrascale electronic devices. Through in situ characterizations using conducting atomic force microscopy, we found a robust high-temperature property of Ca2Nb3O10 nanosheet even in a monolayer form (∼2 nm). Furthermore, layer-by-layer assembled nanocapacitors retained both size-free high-εr characteristic (∼200) and high insulation resistance (∼1×10(-7) A/cm2) at high temperatures up to 250 °C. The simultaneous improvement of εr and thermal stability in high-κ nanodielectrics is of critical technological importance, and perovskite nanosheet has great potential for a rational design and construction of high-temperature capacitors.
Circulating Chemokines in Patients with Autoimmune Thyroid Diseases (2008)

Chemokines are a group of small proteins that recruit different leukocyte subtypes to sites of inflammation and play important roles in initiating and maintaining immunological responses in autoimmune endocrine diseases including Graves' disease (GD) and Hashimoto's thyroiditis (HT). Previous studies have found increased gene and protein expression of different kinds of chemokines not only within the thyroid gland but also within thyroid cells in GD or HT patients. A few studies have determined serum levels of chemokines, with conflicting results. We measured circulating concentrations of CCL2, CCL5, CXCL9, and CXCL10 in patients with GD, HT, and nontoxic nodular thyroid disease (NNT). While CCL2 and CXCL9 concentrations were comparable in patients with either AITD or NNT, CCL5 was significantly increased in GD patients compared with HT or NNT subjects. In contrast, CXCL10 levels were lower in patients with GD, but the difference was statistically significant only when compared with patients with HT (p=0.0018). Importantly, GD patients who relapsed or went into remission had significantly different levels of CXCL9 (p=0.0252). Serum levels of CCL2, CCL5, CXCL9, and CXCL10 did not reveal any correlation with thyroid volume; with the levels of thyrotropin (TSH), FT3, or FT4; or with the titers of TSH receptor antibody and thyroperoxidase antibody. These data suggest that the expression patterns of chemokines in various thyroid diseases differ from each other, which may reflect the distinct immune responses in HT and GD.
Promotion of particle formation by resonance-stabilized radicals during hydrocarbon pyrolysis (2021)

We measured aerosol mass spectra and mobility size distributions of particles formed during the pyrolysis of ethylene, indene, and a mixture of ethylene with a small amount of indene. Measurements were recorded with a scanning mobility particle sizer and an aerosol mass spectrometer employing vacuum ultraviolet photoionization using tunable radiation from the Advanced Light Source at Lawrence Berkeley National Laboratory. The results demonstrate that particle formation occurs at a temperature of ∼1123±50 K for ethylene alone, at ∼923±50 K for indene alone, and at a comparable temperature to that of indene for ethylene seeded with a small amount of indene. Our results demonstrate that indene and indenyl, a resonance-stabilized radical (RSR) formed from indene pyrolysis, promote particle formation at lower temperatures and in the absence of acetylene, supporting the hypothesis that RSRs promote soot-particle inception. Even a small amount of indene added to ethylene promotes particle formation while circumventing the traditional pathways for mass growth by acetylene-addition reactions. Further support is provided by the appearance in the aerosol mass spectra of prominent peaks for masses corresponding to other RSRs from particles formed at lower pyrolysis temperatures. In addition, odd-numbered carbon species, associated with RSRs, appear in higher concentrations at low temperatures and are closely tied to particle inception. In indene pyrolysis, mass signals indicative of covalently bound indenyl dimers and trimers are prominent at pyrolysis temperatures near soot onset. Photoionization efficiency (PIE) curves demonstrate that, while the isomeric composition for some of these peaks may differ between ethylene and indene, the addition of indene to ethylene does not notably alter the isomers formed at these peaks between ethylene and the ethylene-indene mixture. PIE curves also show that m/z 202, which is commonly assumed to be pyrene, is composed principally of fluoranthene under these conditions.
Improving Cloud Security using Secure Enclaves (2016)

Internet services can provide a wealth of functionality, yet their usage raises privacy, security and integrity concerns for users.This is caused by a lack of guarantees about what is happening on the server side.As a worst case scenario, the service might be subjected to an insider attack.This dissertation describes the \\emph{unalterable secure service} concept for trustworthy cloud computing.Secure services are a powerful abstraction that enables viewing the cloud as a true extension of local computing resources.Secure services combine the security benefits one gets locally with the manageability and availability of the distributed cloud.Secure services are implemented using secure enclaves.Remote attestation of the server is used to obtain guarantees about the programming of the service.This dissertation addresses concerns related to using secure enclaves such as providing data freshness and distributing identity information.Certificate Transparency is augmented to distribute information about which services exist and what they do.All combined, this creates a platform that allows legacy clients to obtain security guarantees about Internet services.
Should interferons take front stage as an essential MS disease-modifying therapy in the era of coronavirus disease 2019? (2020)

In the unprecedented pandemic of the coronavirus disease 2019 (COVID-19) along with a limited clinical understanding on effective vaccines and therapies, there are currently many unknowns for patients with autoimmune conditions, such as MS, who require ongoing treatment with immunotherapies. As information is currently lacking on the immune effects of COVID-19 in the context of MS disease-modifying therapies (DMTs), a challenging clinical question being faced by patients and neurologists is whether to continue current DMTs for patients with MS and risk potentially greater morbidity and mortality due to COVID-19 infection vs discontinue DMT therapy and risk MS disease relapse. At this time, we desperately need data to guide which DMTs may best treat both COVID-19 and MS. The authors thank Dr. William Schwartz for critical reading of the manuscript.
ChemInform Abstract: Acid‐Catalyzed Reactions of 3‐(Hydroxymethyl)‐ and 3‐(1‐Hydroxyethyl)pyrazolo(1,5‐a)pyridines. (1990)

ChemInformVolume 21, Issue 22 Heterocyclic Compounds ChemInform Abstract: Acid-Catalyzed Reactions of 3-(Hydroxymethyl)- and 3-(1-Hydroxyethyl)pyrazolo(1,5-a)pyridines. Y. MIKI, Y. MIKI Fac. Pharm. Sci., Kinki Univ., Higashi, Osaka 577, Jap.Search for more papers by this authorN. NAKAMURA, N. NAKAMURA Fac. Pharm. Sci., Kinki Univ., Higashi, Osaka 577, Jap.Search for more papers by this authorH. HACHIKEN, H. HACHIKEN Fac. Pharm. Sci., Kinki Univ., Higashi, Osaka 577, Jap.Search for more papers by this authorS. TAKEMURA, S. TAKEMURA Fac. Pharm. Sci., Kinki Univ., Higashi, Osaka 577, Jap.Search for more papers by this author Y. MIKI, Y. MIKI Fac. Pharm. Sci., Kinki Univ., Higashi, Osaka 577, Jap.Search for more papers by this authorN. NAKAMURA, N. NAKAMURA Fac. Pharm. Sci., Kinki Univ., Higashi, Osaka 577, Jap.Search for more papers by this authorH. HACHIKEN, H. HACHIKEN Fac. Pharm. Sci., Kinki Univ., Higashi, Osaka 577, Jap.Search for more papers by this authorS. TAKEMURA, S. TAKEMURA Fac. Pharm. Sci., Kinki Univ., Higashi, Osaka 577, Jap.Search for more papers by this author First published: May 29, 1990 https://doi.org/10.1002/chin.199022180Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume21, Issue22May 29, 1990 RelatedInformation
Education for Engineering Associates in Australia (1980)

The term engineering associate was adopted in Australia in 1973 to describe those in middle level engineering occupations. Education for such occupations is well developed throughout Australia, predominantly in the TAFE sector, although CAEs in some States also offer middle level associate diploma courses. Enrolments in middle level education has increased during the past decade, with a considerable increase in course completions. The stock of qualified engineering associates in Australia is estimated as 28 - 35000.
MITIGACIÓN DE LA EMISIÓN DE METANO EN LA FERMENTACIÓN RUMINAL, MEDIANTE EL USO DE ÁCIDO 3-NITRO-1-PROPIÓNICO (2017)

Methanogenesis is a metabolic process that allows the rumen ecosystem the ability to maintain low partial pressures of hydrogen needed for proper digestive function. However, rumen methanogenesis is also considered to be an inefficient process because it can result in the loss of 4 to 12% of the total energy consumed by the host. Recent studies have shown that some short chain nitrocompounds such as nitroethane, 2-nitroethanol, 2-nitro-1-propanol and 3-nitro-1-propionic acid are capable of inhibiting the production of methane during in vitro culture; however, optimal supplementation doses have yet to be determined. In the present study, the naturally occurring nitrocompound, 3-nitro-1-propionic acid (3NPA) was supplement to in vitro cultures of freshly collected mixed populations of ruminal microbes to achieve 0, 3, 6, 9 or 12 mM. Analysis of fermentation products after 24 h of incubation revealed that methane production was reduced in a dose-dependent manner by 29 to 96% (P < 0.05) compared to the amount produced by untreated controls (15.03 ± 0.88 µmol mL-1 incubated liquid). Main effects of treatment were also observed on amounts of total gas and volatile fatty acids produced as well as on rates of 3NPA degradation, the latter which varied from 0.07 to 0.30 µmol mL-1. Changes in production of metabolites produced indicated that the caloric fermentation efficiency was not compromised by 3NPA treatment. Results further revealed that the microbial populations were able to metabolize more than 60% of the added nitrocompound, with the amount degraded being greatest in cultures treated with 12 mM 3NPA.
Exploring the tradeoff between waiting time and service cost in non-asymptotic operating regimes (2013)

Motivated by the problem of demand management in smart grids, we study the problem of minimizing a weighted-sum of the mean delay of user demands and the power generation cost, where the latter metric increases with both the mean and the variance of the service demand. The state-of-the-art algorithms for this problem are asymptotically optimal, i.e., they are optimal only when the mean delay of user demands increases to infinity or decreases to zero. Yet, these algorithms may perform poorly for moderate delay, which is the regime in which most applications operate. Hence, there is a pressing need for the design of algorithms that can operate efficiently in the moderate delay regime. We attack this challenging problem in a generic framework by first proposing two classes of parameterized algorithms, which include some existing policies as special instances. Then, we obtain the optimal designs by explicitly characterizing the mean delay and the power generation cost as a function of the algorithmic parameters. The proposed algorithms with the optimal parameters not only are asymptotically optimal but also outperform the existing algorithms uniformly for all cases.
Solid immersion microscope (1990)

A new type of real-time optical microscope has been developed that operates on the same principle as a liquid immersion microscope, with the liquid replaced by a solid lens of high refractive index material. Using a lens with an index n=2 and 436 nm illumination, this microscope has resolved 100 nm lines and spaces and has demonstrated a factor of two improvement in the edge response over a confocal microscope.
Osteogenic differentiation of dental pulp stem cells on porous silicon loaded with β-glycerophosphate. (2011)

1 Laboratoire Biosante Nanoscience EA 4203, Universite Montpellier 1, Montpellier, France. 2 Materiaux Avances Catalyse Sante UMR 5253 CNRS, Institut Charles Gerhardt, Montpellier, France. 3 Laboratoire Charles Coulomb Universite Montpellier 2, UMR 5221 CNRS, Montpellier, France P.Y. Collart Dutilleul1, E. Secret2, C. Gergely3, F. Cunin2, F. Cuisinier1 O-16. OSTEOGENIC DIFFERENTIATION OF DENTAL PULP STEM CELLS ON POROUS SILICON LOADED WITH β-GLYCEROPHOSPHATE