gebhart/patrepeval huggingface dataset:
Lacunar strokes and infarcts (1982)

At least 20 different lacunar syndromes have been described and can be recognized by characteristic clinical features. Almost all occur in patients with hypertension. Small lacunes are usually due to lipohyalinosis, larger ones to atheromatous or embolic occlusion of a penetrating vessel. The concept of the "lacunar state" is examined in the light of recent knowledge with the conclusion that the clinical deficit is primarily related to unrecognized normal pressure hydrocephalus rather than to the presence of a few lacunes. The notion that lacunes occur haphazardly is criticized because the first or only lacune tends to be symptomatic. The incidence of cerebral lacunes has declined since the introduction of antihypertensive therapy, an indication that therapy is effective.
Interactive computation of coverage regions for wireless communication in multifloored indoor environments (1996)

For indoor wireless communication systems, radio frequency (RF) transceivers need to be placed strategically to achieve optimum communication coverage at the lowest cost. Unfortunately, the coverage region for a transceiver depends heavily on the type of building and on the placement of walls within the building. Traditionally, therefore, transceiver locations have been selected by human experts who rely on experience and heuristics to obtain the optimum (or near-optimum) placement. This paper describes an interactive software system that can be used to assist in transceiver placement. It is intended to be easy to use by individuals who are not experts at wireless communication system design. After the user has selected transceiver locations within a graphical floor plan, the system interprets the floor plan and uses simple path loss models to estimate coverage regions for each transceiver. These regions are highlighted, enabling the user to assess the total coverage. This paper describes the methodology used to compute the coverage regions for multifloored buildings and discusses the effect of interference sources. The resulting system is expected to be useful in the specification of indoor wireless systems.
Exploring Multiple Pathways to Low TDD GaP/Si for III-V/Si Photovoltaics (2021)

Threading dislocation density (TDD) is a key parameter that commonly limits the performance of epitaxially integrated III-V/Si photovoltaics. The GaP/Si epitaxial bridge is a widely studied III-V on Si integration pathway, and recent advances have realized low-10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> TDD in n-GaP/Si templates that can be integrated in III-V/Si PV designs amenable to efficiencies well beyond single-junction Si. However, continued development and scaling of III-V/Si PV will ultimately rely on a deeper understanding of dislocation evolution in GaP/Si and will require more process flexibility than has heretofore been demonstrated. Thus, this work demonstrates multiple pathways toward achieving-low 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> TDD, through which we can gain both substantial fundamental understanding of GaP/Si integration and can achieve the needed process flexibility to enable scalable production.
Classic and novel methods of dislocation reduction in heteroepitaxial nitride layers (2005)

Due to the lack of commercially available large size native substrates, reduction of threading dislocations remains one of the main challenges of group III-nitride based technology. This paper reviews major methods aimed at producing high-quality heteroepitaxial nitride films with reduced densities of dislocations. Methods such as, incorporation of buffer layers, substrate nitridation, interlayer insertion, silane-ammonia treatment, lateral overgrowth and growth of thick nitride layers are reviewed. Advantages and drawbacks of these methods are discussed and compared. (© 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
A global optimization framework for meeting summarization (2009)

We introduce a model for extractive meeting summarization based on the hypothesis that utterances convey bits of information, or concepts. Using keyphrases as concepts weighted by frequency, and an integer linear program to determine the best set of utterances, that is, covering as many concepts as possible while satisfying a length constraint, we achieve ROUGE scores at least as good as a ROUGE-based oracle derived from human summaries. This brings us to a critical discussion of ROUGE and the future of extractive meeting summarization.
Application of a Novel S3 Nanowire Gas Sensor Device in Parallel with GC-MS for the Identification of Rind Percentage of Grated Parmigiano Reggiano (2018)

Parmigiano Reggiano cheese is one of the most appreciated and consumed food worldwide, especially in Italy, for its high content of nutrients and for its taste. However, these characteristics make this product subject to counterfeiting in different forms. In this study, a novel method based on an electronic nose has been developed in order to investigate the potentiality of this tool to distinguish rind percentage in grated Parmigiano Reggiano packages that should be lower than 18%. Different samples in terms of percentage, seasoning and rind working process were considered to tackle the problem at 360&amp;deg;. In parallel, GC-MS technique was used to give a name to the compounds that characterize Parmigiano and to relate them with sensors responses. Data analysis consisted of two stages: multivariate analysis (PLS) and classification made in a hierarchical way with PLS-DA ad ANNs. Results are promising in terms of correct classification of the samples. The classification rate is higher for ANNs than PLS-DA, reaching also 100% values.
Management of difficult elbow problems (1992)

Log in or Register Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Register Login HomeCurrent IssuePrevious Issues Current Orthopaedic PracticeCurrent Opinion in Orthopaedics (1999-2007)Clinical Orthopaedics and Related Research (1976-2007) Published Ahead-of-PrintCOP eNewsMy CollectionsJournal Info About the JournalEditorial BoardInformation for AuthorsAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
Phase 1 open-label trial to evaluate the safety and immunogenicity of PAN-301-1, a novel nanoparticle therapeutic vaccine, in patients with biochemically relapsed prostate cancer. (2018)

e15166 Background: PAN-301-1 is a first-in-class therapeutic vaccine candidate targeting human aspartyl (asparaginyl) β-hydroxylase ((HAAH), or aspartate β-hydroxylase (ASPH)). HAAH is an enzyme which demonstrates functionality in fetal development, but is not normally detectable in adult tissues. HAAH is overexpressed and translated to the cell surface in nearly all cancers and is associated with cell growth, motility and invasiveness. PAN-301-1, consisting of inactivated λ-bacteriophage (nanoparticles) that express 200-300 copies of part of the HAAH molecule on the viral head, aims to overcome self-tolerance by this altered antigenic presentation and provide an immunostimulatory effect via phage DNA CpG motifs which activate the MHC class II pathway. Methods: PAN-301-1 was administered intradermally every 21 days in patients with biochemical (PSA) relapsed prostate cancer, using a traditional 3+3 dose-escalation (dose levels of 2E10, 1E11 and 3E11 particles, protein range: 3-40 µg) schema to establish the MTD or R2PD and to determine the DLTs associated with the vaccine. Each patient received ≥ 3 doses of vaccine. Secondary endpoints included safety and immunogenicity parameters as well as a clinical endpoint of assessing serum PSA kinetics. Results: A total of twelve patients received up to 18 doses of PAN-301-1 [median = 10 (3-18) doses/subject] over the 15 month duration of the study. All patients received a minimum of 3 immunizations at the highest dose. The vaccine was well tolerated with minimal adverse events and no DLTs observed at any of the three vaccine dose levels. All subjects experienced dose-dependent HAAH-specific immune responses, including antigen-specific antibody levels in immunoassays and HAAH-specific B-cell and T-cell responses. Of the patients treated at least 3 months, 75 % achieved a decline in PSA levels or a reduction in PSA doubling rate. Conclusions: PAN-301-1 is safe when administered intradermally at doses up to 3E11 particles, induces antigen-specific humoral and cellular immune responses and has provided preliminary indications of efficacy in the reduction of PSA or PSA doubling time. Clinical trial information: NCT03120832.
Strength of Highly Porous Ceramic Electrodes (2011)

Highly porous ceramics are critical components of Solid Oxide Fuel Cells. Nevertheless, their mechanical properties are poor and not fully understood. Herein, Discrete Element simulations are used to quantitatively assess the relation between the particulate microstructure of highly porous ceramics and their mechanical properties. Partially sintered ceramics are numerically generated with complex microstructures including pore formers and bilayers. These microstructures are then tested in tension and compression to obtain their elastic and fracture behavior. Compiling experimental data from the literature and simulations results, an Orowan–Petch type relation between strength and particle size is proposed for highly porous ceramics. It is based on the local fracture model at the length scale of solid bonds between sintered particles.
Thermally-Induced Dehydrogenative Coupling of Organosilanes and H-Terminated Silicon Quantum Dots onto Germanane Surfaces (2020)

Covalently bonded organic monolayers play important roles in defining the solution processability, ambient stability, and electronic properties of two-dimensional (2D) materials such as Ge nanosheets (GeNSs); they also hold promise of providing avenues for the fabrication of future generation electronic and optical devices. Functionalization of GeNS normally involves surface moieties linked through covalent Ge−C bonds. In the present contribution we extend the scope of surface linkages to include Si−Ge bonding and present the first demonstration of heteronuclear dehydrocoupling of organosilanes to hydride-terminated GeNSs obtained from the deintercalation and exfoliation of CaGe2. We further exploit this new surface reactivity and demonstrated the preparation of directly bonded silicon quantum dot-Ge nanosheet hybrids.
Combline filter with tunable bandwidth and centre frequency (2010)

A new method for the design of tunable bandpass filters is presented. It is based on a dual-band combline structure. One of the passband responses centre frequency and bandwidth can be tuned without the need for coupling adjustment, while the other passband can be shifted up in frequency or filtered out. A prototype design has been constructed, and measured results shows wide tuning range and over 300% bandwidth adjustment range, clearly demonstrate the principle.
High pressure frozen oocytes have improved ultrastructure but reduced cleavage rates compared to conventionally fixed or vitrified oocytes (2022)

The HPF method has potential to be developed and lead to improved oocyte and embryo cryopreservation and outcomes for assisted reproduction.
Learning behavior of the eye fixation control system (1963)

While studying the responses of the oculomotor system to horizontally moving visual stimuli some interesting learning patterns were observed. Responses to Gaussian random noise, sine, and square-wave inputs were investigated. Based on small-signal, linear analysis, the system's transfer function was computed on the basis of both sinusoidal and random inputs. Assuming unity feedback, the open-loop transfer function was also computed for both of the above inputs. It is shown that the anticipatory behaviors observed during the tracking of periodic inputs, can be attributed to a prediction operator. This operator is determined by comparing the open-loop transfer functions for both stimuli. It is shown that the effect of this operator is a significant increase in low-frequency gain, and considerable phase-lead; monotonically increasing with frequency.
Mycorrhizal preference promotes habitat invasion by a native Australian orchid: Microtis media (2012)

The findings in M. media support the idea that invasive terrestrial orchids may associate with a diversity of fungi that are widespread and common, enhance seed germination in the host plant but not co-occurring orchid species and tolerate a range of habitats. These traits may provide the weedy orchid with a competitive advantage over co-occurring orchid species. If so, invasive orchids are likely to become more broadly distributed and increasingly colonize novel habitats.
Field evaluation of bridge corrosion protection measures (1993)

Despite over 25 years of experience with the problem of bridge reinforcement corrosion due to chlorides from deicers or sea water exposure, the solution to the problem is still unknown. Many different corrosion protection systems have shown promise in laboratory and preliminary field studies, but their performance on the basis of long-term field tests either has not been evaluated or has been questionable. In the portion of the work discussed in this report, an extensive literature search was conducted to identify corrosion protection systems and field test methods. In addition, a survey of TXDOT districts was conducted to identify corrosion protection systems used in Texas and to determine the districts' experiences concerning the different systems. Most importantly, a field testing program was developed to evaluate and characterize the corrosion performance of bridges and to increase the information learned from corrosion protection system test installations in Texas. Preliminary questionnaire surveys distributed to all the TXDOT districts revealed that many different types of corrosion protection systems have been installed in Texas, but that little information on their performance has been collected from the structures since their completion. The field testing program developed in this study was used to investigate eight preexisting bridges representing different protection systems and various overall exposures and service conditions. The test program, which included determination of half-cell potentials, concrete permeability, chloride content, cracking patterns, and delaminations, was found to accurately reflect the corrosion condition of bridges protected by a variety of corrosion protection measures. The tests selected for use in the field surveys were generally successful and accurate, with different tests confirming each other's results.
Synthesis of CdS hollow spheres coupled with g-C3N4as efficient visible-light-driven photocatalysts (2016)

CdS hollow spheres (CdS HS) coupled with graphitic carbon nitride (g-C3N4) photocatalysts are synthesized and characterized by x-ray diffraction (XRD), transmission electron microscopy (TEM), ultraviolet-visible diffuse reflection spectroscopy (DRS), x-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), and photoluminescence spectroscopy (PL). The effect of CdS content on CdS HS/g-C3N4 activity is investigated by the degradation of Rhodamine B (RhB). The sample of 20 wt% CdS content shows the best photocatalytic performance under visible-light irradiation, with the corresponding RhB degradation rate reaching 97.3%. The excellent photoactivity of CdS HS/g-C3N4 is attributed to the synergistic effect of g-C3N4 and CdS HS. A possible photocatalytic mechanism of the CdS HS/g-C3N4 composite is proposed and corroborated by PL.
AlGaN/GaN $Ka$-Band 5-W MMIC Amplifier (2006)

A broadband Ka-band AlGaN/GaN on SiC high electron-mobility transistor monolithic-microwave integrated-circuit (MMIC) power amplifier was developed for millimeter-wave antenna applications. The 0.18-mum gate two-stage 50-Omega matched MMIC produces 13plusmn1 dB of gain from 26 to 36 GHz. At 35 GHz, the measured continuous wave (CW) saturated output power (P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> ) was 4 W (5 W pulsed), indicating a CW power density of 3.3 W/mm (4.2 W/mm pulsed). The CW power-added efficiency was 23%. Across the band, the measured CW P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> was >2 W (2.5 W pulsed). While individual (or partially matched single stage) devices have been demonstrated with good output power, to the best of our knowledge, this is the first report of a 10-GHz-bandwidth Ka-band GaN MMIC with high output power and gain. A unique aspect of the design, contributing to the wide bandwidth, is the use of positive feedback in the first stage to increase the gain. RF power stress test and detailed investigation of the channel temperature effect are presented. A preliminary RF power stress test indicates a lifetime of 1000 h at 191 degC channel temperature, and elevated temperature operation indicates that P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> decreases by 0.013 dB/degC
Loop calculus and bootstrap-belief propagation for perfect matchings on arbitrary graphs (2013)

Abstract. This manuscript discusses computation of the Partition Function (PF) and the Minimum Weight Perfect Matching (MWPM) on arbitrary, non-bipartite graphs. We present two novel problem formulations- one for computing the PF of a Perfect Matching (PM) and one for finding MWPMs- that build upon the inter-related Bethe Free Energy, Belief Propagation (BP), Loop Calculus (LC), Integer Linear Programming (ILP) and Linear Programming (LP) frameworks. First, we describe an extension of the LC framework to the PM problem. The resulting formulas, coined (fractional) Bootstrap-BP, express the PF of the original model via the BFE of an alternative PM problem. We then study the zero-temperature version of this Bootstrap-BP formula for approximately solving the MWPM problem. We do so by leveraging the Bootstrap-BP formula to construct a sequence of MWPM problems, where each new problem in the sequence is formed by contracting odd-sized cycles (or blossoms) from the previous problem. This Bootstrap-and-Contract procedure converges reliably and generates an empirically tight upper bound for the MWPM. We conclude by discussing the relationship between our iterative procedure and the famous Blossom Algorithm of Edmonds ’65 and demonstrate the performance of the Bootstrap-and-Contract approach on a variety of weighted PM problems. 1.
Integration of Alzheimer’s disease genetics and myeloid genomics reveals novel disease risk mechanisms (2019)

Abstract Genome-wide association studies (GWAS) have identified more than thirty loci associated with Alzheimer’s disease (AD), but the causal variants, regulatory elements, genes and pathways remain largely unknown thus impeding a mechanistic understanding of AD pathogenesis. Previously, we showed that AD risk alleles are enriched in myeloid-specific epigenomic annotations. Here, we show that they are specifically enriched in active enhancers of monocytes, macrophages and microglia. We integrated AD GWAS signals with myeloid epigenomic and transcriptomic datasets using novel analytical approaches to link myeloid enhancer activity to target gene expression regulation and AD risk modification. We nominate candidate AD risk enhancers and identify their target causal genes (including AP4E1, AP4M1, APBB3, BIN1, CD2AP, MS4A4A, MS4A6A, PILRA, RABEP1, SPI1, SPPL2A, TP53INP1, ZKSCAN1, and ZYX) in sixteen loci. Fine-mapping of these enhancers nominates candidate functional variants that likely modify disease susceptibility by regulating causal gene expression in myeloid cells. In the MS4A locus we identified a single candidate functional variant and validated it experimentally in human induced pluripotent stem cell (hiPSC)-derived microglia. Combined, these results strongly implicate dysfunction of the myeloid endolysosomal system in the etiology of AD.
NOx emission indices of subsonic long‐range jet aircraft at cruise altitude: In situ measurements and predictions (1997)

In the course of the Commissions of the European Communities project “Pollution From Aircraft Emissions in the North Atlantic Flight Corridor (POLINAT)”, in situ measurements of NO, NO x , and CO 2 volume mixing ratios in the near‐field exhaust plumes of seven subsonic long‐range jet aircraft have been carried out by using the research aircraft Falcon of the Deutsche Forschungsanstalt für Luft‐ und Raumfahrt (DLR). For three additional aircraft, only NO and CO 2 were measured. Plume ages of 50 s to 150 s have been covered, with maximum observed exhaust gas enhancements of 319 parts per billion by volume and 51 parts per million by volume for Δ[NO x ] and Δ[CO 2 ], respectively, in relation to ambient values. Aircraft cruising altitudes and Mach numbers ranged from 9.1 to 11.3 km and from 0.77 to 0.85, respectively. These measurements are used to derive NO x emission indices for seven of the individual aircraft/engine combinations. The NO x emission indices derived range from 12.3 g/kg to 30.4 g/kg. They are compared with predicted emission index values, calculated for the same aircraft engine and the actual conditions by using two newly developed fuel flow correlation methods. The calculated emission indices were mostly within or close to the error limits of the measured values. On average, the predictions from both methods were 12% lower than the measured values, with an observed maximum deviation of 25%. The ratio γ=[NO 2 ]/[NO x ] found during the present measurements ranged from 0.06 to 0.11 for five daytime cases and was around 0.22 for two nighttime cases. By use of a simple box model of the plume chemistry and dilution these data were used to estimate the initial value γ0 present at the engine exit plane. We found γ0 values between 0 and 0.15. These were applied to estimate the corresponding NO 2 for the three cases in which only NO was measured.