gebhart/patrepeval huggingface dataset:
Chain Structure of Cobra Venom Factor from Naja naja and Naja haje venom (1982)

The chain structure of cobra venom factor, whether isolated from Naja naja venom (CVFn) or from Naja Haje (CVFh) is similar. Both homologous proteins are composed of three disulphide-linked chains (A, B, and C) with apparent molecular weights of 72,000, 54,000, and 27,000-35,000 for CVFn and 68,000, 51,000 and 30,000-32,000 CVFh. That all three polypeptides are integral parts of CVF was demonstrated by investigation of the chain pattern after partial reduction. Reduction with 1-2 mM dithiothreitol under non-denaturing conditions yielded free B-chain, together with an intermediate product composed of disulphide-linked A- and C-chains. The C-chain was heterogenous when investigated by electrophoresis in polyacrylamide slab gels in the presence of SDS. Similarly, isoelectric focusing of CVFn and CVFh showed a multiplicity of bands in the pH range 5.2-6.4. Limited tryptic digestion resulted primarily in the fragmentation of the B-chain. CVFh is much more sensitive to tryptic attack than CVFn. In all our preparations of CVFh a partial, trypsin-like fragmentation of the B-chain was detectable to various extents.
ChemInform Abstract: Structural Consequences of Electron‐Transfer Reactions. Part 18. Redox‐Induced Hapticity Changes: Effect of Substituents on Arene Bending in a Series of Rhodium Complexes. (1989)

Abstract Electrochemical measurements are performed on the Rh(III) arene complexes (Ia), (Ib) and seven differently methylated analogues.
Gender-Based Differences in Outcome After Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction With Hamstring Tendon Autografts (2011)

The results of assessment for ligament laxity at the 2-year postoperative evaluation in the female group were approximately identical to those of the male group after anatomic double-bundle anterior cruciate ligament reconstruction using autogenous hamstring tendons. Therefore, the present study suggests that anatomic double-bundle anterior cruciate ligament reconstruction using autogenous hamstring tendons provides satisfactory knee stability to female patients as well as male patients.
Topical quinolone nadifloxacin (OPC-7251) in bacterial skin disease: clinical evaluation in a multicenter open trial and in vitro antimicrobiological susceptibility testing (1997)

Nadifloxacin (OPC-7251) is a topical fluoroquinolone which inhibits the configuration of supercoiled DNA by DNA gyrase. Previous studies have shown the efficacy of this topical agent in acne vulgaris. The purpose of this open study (clinical phase II) was to investigate the clinical efficacy and tolerability of nadifloxacin 1% cream applied topically in 101 patients with impetigo, secondarily infected wounds, folliculitis and sycosis vulgaris, and impetiginized dermatitis. Efficacy was assessed by counts of lesions and crusts, evaluation of objective and subjective symptoms, and microbiological isolation and identification of aerobic and anaerobic bacteria at baseline and at the end (day 7, or 14, respectively) of the study. The antibacterial activity of nadifloxacin against isolated bacterial strains was also tested in vitro by an agar dilution technique. Nadifloxacin treatment led to a statistically significant reduction in the degree of erythema, exudation, swelling, pain, pruritus, erosion, crusts and scaling, and eradication of causative bacteria was achieved. Three patients reported adverse effects (itching, erythema and inflammatory swelling each in one patient). Physicians’ judgement on efficacy and tolerability was ‘very good’ or ‘good’ in 92% of the patients. Nadifloxacin was active against all aerobic and anaerobic isolates. Causative Staphylococcus aureus, β-hemolytic streptococci and coagulase-negative staphylococci were eradicated in 83%, 100% and 68% of patients, respectively. Minimum inhibitory concentrations were 0.05–0.02 üg/ml for S. aureus, 0.05–3.13 üg/ml for coagulase-negative staphylococci, 0.05–0.78 üg/ml for β-hemolytic streptococci and 0.05–0.78 üg/ml for Propioni-bacterium acnes. All organisms isolated from the lesions before and at the end of the study were highly sensitive and none was resistant to nadifloxacin. In summary, nadifloxacin, a topical quinolone, is a new alternative for topical antibiotic treatment in bacterial skin infection.
Nivolumab plus ipilimumab, with or without enzalutamide, in AR‐V7‐expressing metastatic castration‐resistant prostate cancer: A phase‐2 nonrandomized clinical trial (2021)

Nivolumab plus ipilimumab demonstrated only modest activity in patients with AR-V7-expressing prostate cancer, and was not sufficient to justify further exploration in unselected patients. Stratification by baseline alkaline phosphatase and cytokines (IL-6, -7, and -17) may be prognostic for outcomes to immunotherapy.
[Early results and complications of percutaneous transluminal coronary angioplasty]. (1993)

The authors summarize the early results of coronary angioplasty in 234 patients, with special emphasis on complications. The follow-up group included 182 men (77.8%) and 52 women (22.2%) with a mean age of 52 (34-74) years. Single-artery involvement prevailed (216 patients, 92.3%); multiple artery involvement was diagnosed in 18 patients (7.7%). Overall, dilatation was performed in 273 stenoses; of this number, 213 procedures were successful (78.0%). The primary success rate in the whole group was 76.9% (180/234). The highest success rates were attained in concentric stenoses (88.8%), the lowest ones in complete occlusions (53.8%). Complications were present in 36 patients (15.3%), of this number 14 patients (5.9%) developed acute arterial occlusion; the complications were less severe in 22 patients (9.4%). Of the 14 patients with acute occlusion, eight (3.5%) developed severe complications. One female patient (0.43%) died, one (0.43%) had emergency surgery, and six (2.6%) developed uncomplicated acute myocardial infarction. Perfusion was restored by multiple dilatation in four patients; arterial occlusion, with good collateral circulation, did not result in myocardial infarction in two. Other complications were less severe and had no sequelae including, most often, arterial spasm (3.4%), large dissection demonstrated by angiography (2.6%), protracted hypotension (0.8%), and ventricular fibrillation in one case (0.43%). The article also considers the factors raising the risk of severe complications of coronary angioplasty, and the potential for their prevention and treatment. Coronary angioplasty, employed in an increasing number of patients with symptomatic stenosing atherosclerosis of the coronary arteries, is an effective method successful in 85-95% of patients. The complication rate, while low, is not absolutely negligible.(ABSTRACT TRUNCATED AT 250 WORDS)
Experimental and MD simulation of 3-dodecyloxypropanamine and 3-tetradecyloxypropylamine adsorbed onto quartz (1 0 1) surface (2021)

In this paper, two surfactants, 3-dodecyloxypropanamine (DOPA) and 3-tetradecyloxypropylamine (TOPA), were synthesized and used as collectors in the quartz micro-flotation in the laboratory. Micro-flotation tests, FT-IR, XPS measurements, and ab initio Molecular Dynamics (MD) simulations were conducted to research DOPA, TOPA, and dodecylamine (DDA)'s adsorption mechanisms onto quartz (1 0 1) surfaces. The results of micro-flotation show that the adsorption of DOPA and TOPA onto quartz surface is more robust than that of DDA. The zeta-potential result shows that the DOPA/TOPA was adsorbed on quartz through electrostatic attraction. Then, MD simulation adsorption models were built to compare the computational properties of the three surfactants, such as the radial distribution function, and the interaction energies between the collectors and the quartz cleavage surface. The interaction energies of surfactants (RNH3+ or RNH2) on the quartz surface explained why the pH range of DOPA/TOPA is wider than that of DDA. XPS analyses and MD simulations confirmed that DOPA bonded with the (1 0 1) surface of quartz through three types of hydrogen bonds between the NH2 of DOPA and the O atom of quartz. The hydrogen bonds of type A and type C were the most likely type and more potent than those of type B.
Fabrication of a magnetic tunnel junction-based 240-tile nonvolatile field-programmable gate array chip skipping wasted write operations for greedy power-reduced logic applications (2013)

A nonvolatile field-programmable gate array (NVFPGA) test chip with 240 tiles (the basic components) in a 12 × 20 2D-array is fabricated by 90nm CMOS and 70nm magnetic tunnel junction (MTJ) technologies. Since not only circuit configuration data but also temporal data are still remained in the MTJ devices even when the power supply is cut off, standby power dissipation is completely eliminated by utilizing tile-level power gating. Power reduction is further accelerated by skipping wasted write operations of nonvolatile flip-flops (NVFFs) for storing temporal data when the temporal data and the stored one are the same. As a typical application, a motion-vector prediction function is implemented on the proposed NVFPGA, which results in a write power reduction of 77% compared to that of a conventional MTJ-based NVFPGA and a total power reduction of 70% compared to that of an SRAM-based FPGA.
Modelization of photosynthetic and respiratory maximal activities as a function of culture parameters in Chlamydomonas reinhardtii using design of experiment and data analysis by JMP (SAS Institute) (2013)

We aimed to modelize the dependence of photosynthetic as well as cytochromial and alternative respiratory maximal activities upon different culture parameters, i.e. light intensity and acetate, carbon dioxide, nitrate and ammonium concentrations, in the model unicellular green alga Chlamydomonas reinhardtii. Culture parameters were submitted to a dedicated statistical software (JMP 10.0, SAS Institute) for the generation of a design of experiment. Measurements of oxygen concentrations were carried out to quantify maximal activities. JMP was further used to detect culture parameters exerting a statistically significant effect on maximal activities and to modelize the dependence of maximal activities upon these culture parameters of interest.
The Cerato-Platanin protein Epl-1 from Trichoderma harzianum is involved in mycoparasitism, plant resistance induction and self cell wall protection (2015)

Trichoderma harzianum species are well known as biocontrol agents against important fungal phytopathogens. Mycoparasitism is one of the strategies used by this fungus in the biocontrol process. In this work, we analyzed the effect of Epl-1 protein, previously described as plant resistance elicitor, in expression modulation of T. harzianum genes involved in mycoparasitism process against phytopathogenic fungi; self cell wall protection and recognition; host hyphae coiling and triggering expression of defense-related genes in beans plants. The results indicated that the absence of Epl-1 protein affects the expression of all mycoparasitism genes analyzed in direct confrontation assays against phytopathogen Sclerotinia sclerotiorum as well as T. harzianum itself; the host mycoparasitic coiling process and expression modulation of plant defense genes showing different pattern compared with wild type strain. These data indicated the involvement T. harzianum Epl-1 in self and host interaction and also recognition of T. harzianum as a symbiotic fungus by the bean plants.
A secure Email gateway (building an RCAS external interface) (2002)

Fielding secure computer systems requires tradeoffs between functionality, flexibility, and security to meet the users' needs. Multilevel secure (MLS) computer systems provide better control over classified information than traditional systems and allow users from a diverse population access to information they need while protecting sensitive data. Users want the functionality of non-MLS computer systems; graphical user interfaces, a rich assortment of software, and electronic connectivity with other systems. Compartmented mode workstations (CMW) can provide such an environment. An overview of secure system architectures and an example MLS network provide the framework for discussing the risks associated with interconnecting MLS systems and unclassified networks, and approaches for mitigating those risks. A secure Email gateway, using a high-assurance (AI) network component, provides the necessary safeguards for protecting the MLS network from external attacks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Categorized color space on CRT in the aperture and the surface color mode (1993)

Abstract The study was made for structure of categorized color space in the aperture and the surface color modes. The color appearances of two modes were reproduced on a CRT display with or without a surround configuration. Subjects made categorical color naming with 11 basic color terms. The (x,y,L) color space divided with these terms showed structural difference between the two modes. This result indicates that color is categorized by only chromaticity in the aperture color mode but by luminance and chromaticity in the surface color mode. © 1993 John Wiley &amp; Sons, Inc.
Uncertainty quantification of thermal image-based concrete diagnosis (2015)

This paper investigates uncertainty quantification in internal damage diagnosis in concrete based on thermal imaging. Thermal imaging can be used for detection, localisation, as well as quantification of the damage. The proposed methodology for uncertainty quantification aggregates various sources of uncertainty introduced at each step of image processing. Further, global sensitivity analysis is applied to identify the dominant contributors to diagnosis uncertainty. Based on the results of uncertainty quantification and global sensitivity analysis, a Bayesian technique is formulated to identify the optimal values of parameters to be selected at each step of the image processing, in order to minimise the uncertainty in diagnosis. An illustrative example of damage diagnosis of a concrete slab is used to examine the effectiveness of the proposed uncertainty quantification and parameter selection methods.
A procedure for placing pediatric femoral venous catheter tips near the right atrium (2002)

The use of the SUP index ensures acceptable accuracy in estimating the required insertion length of femoral catheter when tip placement near the right atrium is the clinical goal.
New Anti-HIV-1, Antimalarial, and Antifungal Compounds from Terminalia bellerica (1997)

A bioactivity-guided fractionation of an extract of Terminalia bellerica fruit rind led to the isolation of two new lignans named termilignan (1) and thannilignan (2), together with 7-hydroxy-3',4'-(methylenedioxy)flavan (3) and anolignan B (4). All four compounds possessed demonstrable anti-HIV-1, antimalarial, and antifungal activity in vitro.
Eutrophication: The Microbial Response to High Nutrient Levels (2004)

This chapter contains sections titled: Nutrient status of freshwater environments: from oligotrophic to eutrophic systems General biological changes Biological assessment of water quality Problems with intentional eutrophication: destabilization of fishpond ecosystems Algal blooms and eutrophication Formation of colonial blue-green algal blooms Environmental effects of blue-green blooms Strategies for the control of blue-green algae Biological control of blue-green algae Strategies for the control of blue-green algae in different water bodies
A cell-surface molecule involved in organ-specific homing of lymphocytes. 1983. (2006)

Lymphocytes migrate from the bloodstream by recognizing and binding to specialized endothelial cells lining the high endothelial venules (HEV) in lymph nodes and Peyer's patches. We describe here a monoclonal antibody, MEL-14, specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV, and to be required for lymphocyte homing into lymph nodes in vivo.
Non‐contrast‐enhanced MR angiography for selective visualization of the hepatic vein and inferior vena cava with true steady‐state free‐precession sequence and time‐spatial labeling inversion pulses: Preliminary results (2009)

True SSFP scan with T-SLIPs enabled selective visualization of the hepatic vein and IVC without an exogenous contrast agent.
Delayed Treatment with Monoclonal Antibody IN-1 1 Week after Stroke Results in Recovery of Function and Corticorubral Plasticity in Adult Rats (2005)

Neuronal death due to ischemic stroke results in permanent deficits in sensory, language, and motor functions. The growth-restrictive environment of the adult central nervous system (CNS) is an obstacle to functional recovery after stroke and other CNS injuries. In this regard, Nogo-A is a potent neurite growth-inhibitory protein known to restrict neuronal plasticity in adults. Previously, we have found that treatment with monoclonal antibody (mAb) IN-1 to neutralize Nogo-A immediately after stroke enhanced motor cortico-efferent plasticity and recovery of skilled forelimb function in rats. However, immediate treatment for stroke is often not clinically feasible. Thus, the present study was undertaken to determine whether cortico-efferent plasticity and functional recovery would occur if treatment with mAb IN-1 was delayed 1 week after stroke. Adult rats were trained on a forelimb-reaching task, and the middle cerebral artery was occluded to induce focal cerebral ischemia to the forelimb sensorimotor cortex. After 1 week, animals received mAb IN-1 treatment, control antibody, or no treatment, and were tested for 9 more weeks. To assess cortico-efferent plasticity, the sensorimotor cortex opposite the stroke lesion was injected with an anterograde neuroanatomical tracer. Behavioral analysis demonstrated a recovery of skilled forelimb function, and anatomical studies revealed neuroplasticity at the level of the red nucleus in animals treated with mAb IN-1, thus demonstrating the efficacy of this treatment even if administered 1 week after stroke.
Posttraumatic Growth in Trauma Survivors: Meaning Making and Locus of Control (2019)

A multi-dimensional time-series is a sequence of vectors measured by many devices at points in time. Although many methods have been proposed to model and classify the data, these methods lead to a problematic relationship between cost and accuracy. In this paper, we propose a novel method for approximating multi-dimensional time-series, named multi-dimensional time-series Approximation with use of Local features at Thinned-out Keypoints (A-LTK), which enables an adequate accuracy value to be obtained even when reduced storage cost is a requirement. The main concepts of A-LTK are 1) reduction of time points and 2) construction of local features at the thinned-out keypoints. A preliminary evaluation indicated that with these points our proposed method was capable of achieving almost the same accuracy with less storage cost, compared to existing methods.
Chronic hypoxia induces nonreversible right ventricle dysfunction and dysplasia in rats (2004)

The purpose of this study was to evaluate the reversibility of right ventricular (RV) remodelling after pulmonary artery hypertension (PAHT) secondary to 3 wk of hypobaric hypoxia. A group of 10 adult male Wistar rats were studied and were the following: control normoxic (C), after 3 wk of chronic hypoxia (CH), and after 3 wk of exposure to hypoxia followed by 3 wk of normoxia recovery (N-RE). Mean pulmonary artery pressure was 11 +/- 2 mmHg in the C group, 35 +/- 2 mmHg in the CH group, and 14 +/- 3 mmHg in the N-RE group. RV function was assessed by echocardiography. In the CH group, the pulmonary flow measured in Doppler mode depicted a midsystolic notch and a decrease of the pulmonary acceleration time compared with control [17 +/- 1 vs. 34 +/- 1 ms (n = 10), respectively; P < 0.05]. RV thickening measured in M-mode was apparent in the CH group compared with the control group [2.84 +/- 0.40 vs. 1.73 +/- 0.26 mm (n = 10), P < 0.05]. In the N-RE group, the RV wall was significantly thinner compared with the CH group [1.56 +/- 0.08 vs. 1.73 +/- 0.26 mm (n = 10), P < 0.05]. The calculated RV diameter shortness fraction was not different between the CH group and C group (34 +/- 4.2% vs. 36 +/- 2.8%) but decreased in the N-RE group [20 +/- 2.4% (n = 10), P < 0.01]. The E-to-A wave ratio on the tricuspid Doppler inflow was significantly lower in the CH group and N-RE group compared with the C group [0.70 +/- 0.8 and 0.72 +/- 0.1 vs. 0.88 +/- 0.2 (n = 10), respectively; P < 0.05]. In the isolated perfused heart using the Langendorff method, RV compliance was increased in the CH group and decreased in the N-RE group. In the N-RE group, fibrous bands with metaplasia were observed on histological sections of the RV free wall. We conclude that PAHT induces nonreversible RV dysfunction with dysplasia.
Crystallization of bacterioferritin fromBlastochloris viridis (2012)

Due to their obvious interest as the building units of proteins and their role in many metabolic processes, amino acids were among the first chiral compounds to be investigated with X-ray diffraction methods. Prior to the present investigation, crystal structures were known for the enantiomeric form of 18 out of the 20 standard amino acids, with L-tryptophan (L-Trp) and L-lysine still missing. A disorder-free structure in space group P1 has now been established for L-Trp (I). Key features are the hydrogen-bond pattern not previously observed in crystal structures of amino acids and the occurrence of no less than 16 molecules in the asymmetric unit. In the crystal structure of DL-Trp [1], with Z' = 1, aromatic side chains form characteristic hydrophobic layers with >N-HC(p) interactions. Part of the complexity of (I) is the result of the way the stacking arrangement of DL-Trp is mimicked by letting molecules in two different conformations play the roles of the L-and D-enantiomers in the crystal structure of the racemate. Extended pseudosymmetry gives rise to very unusual systematic absences in the diffraction pattern.
The endolysins of bacteriophages CMP1 and CN77 are specific for the lysis of Clavibacter michiganensis strains (2010)

Putative endolysin genes of bacteriophages CMP1 and CN77, which infect Clavibacter michiganensis subsp. michiganensis and C. michiganensis subsp. nebraskensis, respectively, were cloned and expressed in Escherichia coli. The His-tagged endolysin of CMP1 consists of 306 amino acids and has a calculated molecular mass of 34.8 kDa, while the His-tagged endolysin of CN77 has 290 amino acids with a molecular mass of 31.9 kDa. The proteins were purified and their bacteriolytic activity was demonstrated. The bacteriolytic activity of both enzymes showed a host range which was limited to the respective C. michiganensis subspecies and did not affect other bacteria, even those closely related to Clavibacter. Due to the high specificity of the CMP1 and CN77 endolysins they may be useful tools for biocontrol of plant-pathogenic C. michiganensis without affecting other bacteria in the soil.