gebhart/patrepeval huggingface dataset:
Vesicle-associated Membrane Protein (VAMP) Cleavage by a New Metalloprotease from the Brazilian Scorpion Tityus serrulatus (2009)

We present evidence that venom from the Brazilian scorpion Tityus serrulatus and a purified fraction selectively cleave essential SNARE proteins within exocrine pancreatic tissue. Western blotting for vesicle-associated membrane protein type v-SNARE proteins (or synaptobrevins) reveals characteristic alterations to venom-treated excised pancreatic lobules in vitro. Immunocytochemistry by electron microscopy confirms both the SNARE identity as VAMP2 and the proteolysis of VAMP2 as a marked decrease in secondary antibody-conjugated colloidal gold particles that are predominantly associated with mature zymogen granules. Studies with recombinant SNARE proteins were used to determine the specific cleavage site in VAMP2 and the susceptibility of VAMP8 (endobrevin). The VAMP2 cleavage site is between the transmembrane anchor and the SNARE motif that assembles into the ternary SNARE complex. Inclusion of divalent chelating agents (EDTA) with fraction nu, an otherwise active purified component from venom, eliminates SNARE proteolysis, suggesting the active protein is a metalloprotease. The unique cleavages of VAMP2 and VAMP8 may be linked to pancreatitis that develops following scorpion envenomation as both of these v-SNARE proteins are associated with zymogen granule membranes in pancreatic acinar cells. We have isolated antarease, a metalloprotease from fraction nu that cleaves VAMP2, and report its amino acid sequence.
Antibacterial action of gramicidin S and tyrocidines in relation to active transport, in vitro transcription, and spore outgrowth (1982)

The cyclopeptide antibiotic gramicidin S or tyrocidine in concentrations of 2 to 4 mumol/mg of membrane protein inhibited the active transport of [3H]alanine and [3H]uridine in membrane vesicles isolated from Bacillus brevis and Bacillus subtilis. We used one analog of gramicidin S and two of tyrocidine A to study the relationship between peptide structure and antibacterial action as seen in inhibiting active transport and in vitro transcription and in delaying spore outgrowth. The data showed that [Ser2,2']-gramicidin S, in which the two ornithine residues were replaced by two serines, was at least 50 times less active antibacterially and gave a low response in transport inhibition and delay of spore outgrowth compared with the natural peptide. The antibacterial activity of [Val6]-tyrocidine A was twice lower than that of tyrocidine A, and it also showed a considerable reduction in transport and transcription inhibition. [Orn7]-tyrocidine A containing two ornithine residues in positions corresponding to those in gramicidin S was almost inactive in all functions tested. The correlation between peptide structure and activity is discussed.
A Testbed for Real-Time Performance Evaluation of RSS-based Indoor Geolocation Systems in Laboratory Environment (2005)

Recently, there has been an enormous growth of interests in geolocation applications that demand an accurate estimation of the userÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢s location in indoor areas. The traditional geolocation system, GPS, which was designed for being used in outdoor environments, does not perform well in indoor areas, causing frequent inaccuracies in location estimation. Therefore the need for more accurate positioning systems and even positioning techniques is a motivation for researchers to turn their attention into indoor positioning systems. In this thesis we present a unique testbed for indoor geolocation systemÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢s real-time performance evaluation. Then we present a real-time performance evaluation of a sample indoor positioning system. We make a comparison between the simulated results of the performance evaluation of the positioning engine and the real-time performance evaluation of the positioning system. Finally, we perform a sensitivity analysis for EkahauÃƒÂ¢Ã¢â‚¬Å¾¢ indoor positioning engine. We show that the simulation with the introduced testbed yields the same results as one would obtain by evaluating the performance of the positioning system by means of massive measurement campaigns. Running the testbed for several measurement campaigns for different scenarios enabled us to compare the results and study the effect of selected parameters on the performance of the positioning system. We also perform primitive error analysis in terms of distance error to verify the validity of the result obtained with the testbed. We show that under the same configuration both real-time performance evaluation and simulated performance evaluation will yield same result with respect to position error. We also use error modeling to determine which error model is best matched to the observed indoor positioning error. Amongst all of the possibilities of choosing methods of positioning, we focused on the Received Signal Strength (RSS) based method along with fingerprinting. Briefly said, profiles previously gathered by measurement or simulation will decide on the location of mobile terminal if a new profile comes in. It is worth mentioning that previous work similar to this testbed has been done for outdoor areas according to Ekahau's white paper. Their work is mainly focused on outdoor environment, in which multipath does not exist. In this research effort we tried to analyze the effect of different parameters on sensitivity of indoor positioning systems who suffer from multipath. Different setups for simulating real-time radio channels have been studied in literature, but still not focused on indoor areas.
Evaluation of a handheld NIRS instrument for determining haylage dry matter (2023)

Abstract Accurate forage dry matter (DM) concentration estimation is essential for maximizing animal performance and minimizing feed costs. One possible method of estimating DM for rebalancing rations daily involves the use of hand‐held near infrared reflectance spectrometer instruments. The SCiO Cup is one of the hand‐held instruments that could be used to estimate forage DM, but a thorough evaluation of its effectiveness has not been conducted. Haylage samples ( n = 600) from 143 bunker silos were collected across New York State over three years, and vacuum packed for eventual analysis using a SCiO Cup. Samples ranged from pure alfalfa ( Medicago L.) to pure grass but were mostly from mixed species. All but one sample received a DM value estimated from several available calibrations pre‐loaded in the device. Sixty samples (representing 10% of the sample population) were too wet or dry to generate a result using the mixed silage calibration. For the remaining 90% of samples, SCiO Cup DM estimates were within 3.22%units of oven DM 80% of the time. Precision of the instrument evaluated with multiple scanning of samples using the mixed silage calibration was very good, with the average standard deviation of three values of 0.40 ( n = 200). The mixed silage calibration was more effective for predicting DM of this set of haylages than either legume or grass silage calibrations.
Real time workload classification from an ambulatory wireless EEG system using hybrid EEG electrodes (2008)

This paper describes a compact, lightweight and ultra-low power ambulatory wireless EEG system based upon QUASAR's innovative noninvasive bioelectric sensor technologies. The sensors operate through hair without skin preparation or conductive gels. Mechanical isolation built into the harness permits the recording of high quality EEG data during ambulation. Advanced algorithms developed for this system permit real time classification of workload during subject motion. Measurements made using the EEG system during ambulation are presented, including results for real time classification of subject workload.
A Small Molecule Modulates Circadian Rhythms through Phosphorylation of the Period Protein (2011)

Zeitverschiebung: Ein zellbasiertes Hochdurchsatz-Screening lieferte ein Benzothiazolanalogon, LH846, das die Phasen des Tag-Nacht-Rhythmus verlängert. Affinitätschromatographie in Kombination mit massenspektrometrischer und genomischer Analyse identifizierte die Proteinkinase CKIδ als das biologische Ziel von LH846 (siehe Bild).
The Ketogenic Diet: Seizure Control Correlates Better With Serum β-Hydroxybutyrate Than With Urine Ketones (2000)

The objective of this study was to determine the relationship between beta-hydroxybutyrate levels and seizure control in children on the ketogenic diet. Seventy-four children on the ketogenic diet presenting for routine follow-up visits had blood levels of beta-hydroxybutyrate correlated with their seizure control. Forty-two children admitted for initiation of the ketogenic diet had urine ketones measured by dipstick and correlated with simultaneous blood levels of beta-hydroxybutyrate. Blood beta-hydroxybutyrate levels statistically correlated with seizure control (P = .003). Children with blood beta-hydroxybutyrate levels greater than 4 mmol/L were significantly more likely to have a decrease in seizure frequency than those with levels less than 4 mmol/L. Urine ketones of 4+ (160 mmol/L) were found on dipstick when blood beta-hydroxybutyrate levels exceeded 2 mmol/L. Seizure control correlates with blood beta-hydroxybutyrate levels and is more likely when blood beta-hydroxybutyrate levels are greater than 4 mmo/L. The traditional measurement of urine ketones by dipsticks in children on the ketogenic diet provides a less than optimal assessment of the degree of blood ketosis. Three to four plus (80-160 mmol/L) urine ketones are necessary, but not necessarily sufficient, to achieve optimal seizure control in children on the ketogenic diet. At present, however, urine ketones are the only readily available inexpensive approach to ketone assessment.
New Insights into the High‐Pressure Processing of Meat and Meat Products (2012)

Abstract: For years, high‐pressure processing has been viewed as useful for pasteurizing food while maintaining the quality of fresh food. However, even at moderate pressure, this process is not without effects on food, especially on meat products. These effects are especially important because pressure greater than 400 MPa is generally necessary to achieve efficient microbial inactivation. In this review, recent advances in the understanding of the impacts of high pressure on the overall quality of raw and processed meat are discussed. Many factors, including meat product formulation and processing parameters, can influence the efficiency of high pressure in pasteurizing meat products. It appears that new strategies are applied either (i) to improve the microbial inactivation that results from high pressure while minimizing the adverse effects of high pressure on meat quality or (ii) to take advantage of changes in meat attributes under high pressure. Most of the time, multiple preservation factors or techniques are combined to produce safe, stable, and high‐quality food products. Among the new applications of high‐pressure techniques for meat and meat‐derivative products are their use in combination with temperature manipulation to texturize and pasteurize new meat products simultaneously.
Ultrasonic NDT data reconstruction, visualization and analysis in AutoCAD®2000 (2001)

This paper describes an implementation of 3D ultrasound data reconstruction, display and analysis within AutoCAD®2000. In addition, a number of standard weld templates, scalable via dialog boxes, have been implemented. Currently, MIPS (Micropulse) formatted data can be imported, reconstructed and displayed. A series of dialog boxes allows specification of the scanning configuration. The reconstruction algorithm takes full account of reflection and mode conversion at the component surfaces. The resultant ultrasound image is presented in ‘3D,’ with tools for image manipulation and interrogation.
Systematic Review: Contribution of the Gut Microbiome to the Volatile Metabolic Fingerprint of Colorectal Neoplasia (2022)

Colorectal cancer (CRC) has been associated with changes in volatile metabolic profiles in several human biological matrices. This enables its non-invasive detection, but the origin of these volatile organic compounds (VOCs) and their relation to the gut microbiome are not yet fully understood. This systematic review provides an overview of the current understanding of this topic. A systematic search using PubMed, Embase, Medline, Cochrane Library, and the Web of Science according to PRISMA guidelines resulted in seventy-one included studies. In addition, a systematic search was conducted that identified five systematic reviews from which CRC-associated gut microbiota data were extracted. The included studies analyzed VOCs in feces, urine, breath, blood, tissue, and saliva. Eight studies performed microbiota analysis in addition to VOC analysis. The most frequently reported dysregulations over all matrices included short-chain fatty acids, amino acids, proteolytic fermentation products, and products related to the tricarboxylic acid cycle and Warburg metabolism. Many of these dysregulations could be related to the shifts in CRC-associated microbiota, and thus the gut microbiota presumably contributes to the metabolic fingerprint of VOC in CRC. Future research involving VOCs analysis should include simultaneous gut microbiota analysis.
Tandem isomerisation–carbonylation catalysis: highly active palladium(ii) catalysts for the selective methoxycarbonylation of internal alkenes to linear esters (2001)

Fast, selective conversion of internal olefins to linear esters is catalysed by Pd(II) complexes of chelating bis(phospha-adamantyl)diphosphines and the catalysis is acutely sensitive to the ligand backbone and even to the diastereomer used; the results are compared with those for the PBut2 analogue.
1H-NMR studies on the physical state of water in living systems-basic studies and clinical applications. (1994)

It is well-known that water plays a major role in a large number of biological processes in living systems and it is also commonly believed that the properties of water near interfaces are quite different from those of the bulk water by the interaction between water and interfaces. Living systems, such as cells and tissues are very rich in such interfaces due to the existence of the cellular cytoskeleton.While conducting 360MHz 1H-NMR studies on cross-relaxation phenomena in protein gel and solution, and in rat normal and hepatocellular tumor, we found that intermolecular cross-relaxation times (TIS) from irradiated protein protons to water protons are a sensitive parameter of water-macromolecule interaction and that TIS imaging could provide new information on the difference in the interaction of water with the macromolecule in vivo.
ChemInform Abstract: Tubular Silicate‐Layered Silicate Intercalation Compounds: A New Family of Pillared Clays. (1989)

Abstract It is shown that a sol containing the tubular metal oxide imogolite ((OH) 3 Al 2 O 3 Si(OH)) can be directly intercalated as a regular monolayer in the galleries of smectite clays such as montmorillonite, fluorohectorite, and hectorite.
Probing Quark-Gluon Interactions with Transverse Polarized Scattering (2010)

We have extracted QCD matrix elements from our data on doubly polarized inelastic scattering of electrons on nuclei. We find the higher twist matrix element d˜2, which arises strictly from quark-gluon interactions, to be unambiguously nonzero. The data also reveal an isospin dependence of higher twist effects if we assume that the Burkhardt-Cottingham sum rule is valid. The fundamental Bjorken sum rule obtained from the a0 matrix element is satisfied at our low momentum transfer.
Pharmacological evaluation of portal venous isolation and charcoal haemoperfusion for high-dose intra-arterial chemotherapy of the pancreas (1997)

These results indicate that PVI-CHP can produce a significant reduction in systemic drug exposure and may allow dose intensification during intra-arterial chemotherapy for the pancreas.
Self/Non-Self Recognition in Invertebrates (1984)

The existence of a method of cellular self/non-self recognition seems to be critical for the efficient functioning of all metozoans. In the vertebrates, self/non-self discrimination by the immune system is to a large extent achieved by means of antibody molecules that are specific for foreign determinants. This article considers how, in the absence of antibody, invertebrate animals might recognize and eliminate foreign material. The evidence which indicates that phagocytic cells are involved in the removal of foreign material from the tissues of both coelomate and acoelomate invertebrates is discussed. The removal of particles appears to be selective, the selection occuring at the cell surface. The evidence indicates that some invertebrates may possess a capacity for specific recognition of self, and hence it is argued that the simplest mechanism of ensuring self-tolerance is one where self is specifically recognized. Nevertheless, a few studies have indicated that some invertebrates may utilize receptors on the surfaces of phagocytic cells, or serum opsonins, or both systems to select foreign particles that are to be phagocytosed. In a couple of instances, the opsonic activity seems to be attributable to agglutinin molecules present in the hemolymph of these invertebrates. In order to ensure self-tolerance in situations where opsonins or phagocyte receptors bind self cells in addition to foreign particles-i.e., where these molecules bind to a common determinant on cell surfaces-a two-signal controlling mechanism is envisaged. The adhesion of particles to a phagocyte by means of opsonins or phagocyte receptors, in such a case, could stimulate ingestion (signal 1) unless the phagocyte simultaneously received a "don't kill" signal (signal 2) resulting from the occupancy of its self-recognition receptors. Support for aspects of this model is found in the literature, although studies capable of withstanding critical analysis are limited.
Ligand Binding and Polymerization Characteristics of Human Milk Folate Binding Protein Depend on Concentration of Purified Protein and Presence of Amphiphatic Substances (2003)

Two folate binding proteins are present in human milk; one of 27 kDa is a cleavage product of the other one (100 kDa) which possesses a hydrophobic membrane anchor. A drastic change of radioligand binding characteristics and appearance of aggregated weak-radioligand affinity forms on gel filtration occurred at low concentrations of both proteins in the absence of Triton X-100 or other amphiphatic substances, e.g. cetyltrimethylammonium and phospholipids. These findings are consistent with a model predicting association between unliganded and liganded monomers resulting in weak-ligand affinity dimers. Amphiphatic substances form micelles and lipid bilayers which could separate hydrophobic unliganded monomers from hydrophilic liganded monomers (monomers become hydrophilic in the liganded state) thereby preventing association between these monomeric forms prevailing at low concentrations of the protein. Bio-Gel P-300 chromatography of the 27 kDa protein revealed a pronounced polymerization tendency, which diminished with decreasing protein concentrations, however, not in the presence of cetyltrimethylammonium. The data could have some bearings on observations indicating that naturally occurring amphiphatic substances, cholesterol and phospholipids, are necessary for the important clustering of membrane folate receptors.
Multiple relay robots-assisted URLLC for industrial automation with deep neural networks (2022)

In this paper, we propose to use multiple mobile robots as relay terminals to assist the wireless connectivity between the base stations and industrial Internet-of-Things (IIoT) devices. Under the strict latency constraint via short blocklength, we propose an optimal resource allocation scheme to minimise the error probability at the IIoT devices. For fast deployment, we propose a deep neural network to optimise the positions of the mobile robots. Then, a joint blocklength and power allocation optimisation of the base stations and relay robots is considered. Due to non-convexity of such optimization problem, we propose a sub-problem with an effective iterative algorithm for solving the reliability maximisation. Representative numerical results are provided to demonstrate the advantages of our proposed scheme over the conventional approach.
Design of N -way distributed Doherty amplifier for WCDMA and OFDM applications (2007)

A novel three-way distributed Doherty power amplifier with an extended efficiency range for WCDMA or OFDM repeater or base-station applications is presented. This distributed Doherty amplifier consists of one main amplifier and two peaking amplifiers. To achieve high efficiency at a high back-off power, the peaking amplifier structure is based on the dual-fed distributed amplifier form. The 2140 MHz measured results of the three-way distributed Doherty amplifier yielded an 11 dB power gain, with 39.5% power added efficiency at 9.5 dB back-off power.
A Low Latency Scalable 3D NoC Using BFT Topology with Table Based Uniform Routing (2014)

Due to the limitations of traditional bus based systems, Network-on-Chip (NoC) has evolved as the most dominanttechnology in the paradigm of communication-centric revolution, where, besides the computation, inter-communication between the cores is an indispensable aspect of a SoC. Furthermore, the emergence of three dimensional integrated circuits (3D-ICs) has resulted in better performance, functionality, and packaging density compared to traditional planar ICs. The amalgamation of these two technologies, the 3D NoC architecture, can combine the benefits of these two new domains to offer an unprecedentedperformance gain. In this paper, we present a new 3D topological NoC design based on the butterfly fat tree (BFT) topology with an efficient table based uniform routing algorithm for 3D NoC. Extensive simulation experiments have been performed for BFT and compared to mesh, torus, butterfly and flattened butterfly topologies against four performance metrics viz. overall average latency, overall average acceptance rate, overall minimum acceptance rate, and average hop counts. There are significant latency improvements of 43-89 %, 83-88 %, 46-96 %, and 31-95 % over other topologies respectively. Average hop count is improved by 30 % and 13 % over mesh and torus. Also, there are improvements in average acceptance rate and minimum acceptance rate of 1-8 % and 5-14 % respectively for flattened butterfly and 6-9 % and 6-13 % over torus. Results evidently show that BFT is a very good choice for low network latency and faster communication.
Reactions of Amines with Esters of Polyhalogenated Acids (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Amines with Esters of Polyhalogenated AcidsMadeleine M. JoulliéCite this: J. Am. Chem. Soc. 1955, 77, 24, 6662–6663Publication Date (Print):December 1, 1955Publication History Published online1 May 2002Published inissue 1 December 1955https://pubs.acs.org/doi/10.1021/ja01629a090https://doi.org/10.1021/ja01629a090research-articleACS PublicationsRequest reuse permissionsArticle Views225Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts