gebhart/patrepeval huggingface dataset:
The Effect of Adverse Surgical Margins on the Risk of Biochemical Recurrence after Robotic-Assisted Radical Prostatectomy (2022)

Positive surgical margins (PSM) after radical prostatectomy are associated with a greater risk of biochemical recurrence (BCR). However, not all PSM harbour the same prognosis for recurrence. We aim to determine the impact of different PSM characteristics and their coexistence on the risk of BCR. This retrospective study included 333 patients that underwent robotic-assisted radical prostatectomy for prostate cancer between 2015−2020 at a single institution. The effect of PSM and their adverse characteristics on the risk of BCR was assessed using Cox proportional hazard models. Kaplan−Meier was used to represent BCR-free survival stratified by margin status. With a median follow-up of 34.5 months, patients with PSM had a higher incidence of BCR, higher risk of relapse and lower BCR-free survival than negative margins (p < 0.001). We established as adverse characteristics: PSM length ≥ 3 mm, multifocality and Gleason at margin > 3. PSM ≥ 3 mm or multifocal PSM were associated with an increased risk for BCR compared to favourable margins (HR 3.50; 95% CI 2.05−5.95, p < 0.001 and HR 2.18; 95% CI 1.09−4.37, p = 0.028, respectively). The coexistence of these two adverse features in the PSM also conferred a higher risk for biochemical relapse and lower BCR-free survival. Adverse Gleason in the margin did not confer a higher risk for BCR than non-adverse margins in our models. We concluded that PSM are an independent predictor for BCR and that the presence of adverse characteristics, such as length and focality, and their coexistence in the PSM are associated with a greater risk of recurrence. Nevertheless, subclassifying PSM with adverse features did not enhance the model’s predictive performance in our cohort.
Maximizing Profits for North American Van Lines' Truckload Division: A New Framework for Pricing and Operations (1988)

The Commercial Transport Division of North American Van Lines dispatches thousands of trucks from customer origin to customer destination each week under high levels of demand uncertainty. Working closely with upper management, the project team developed a new type of network model for assigning drivers to loads. The model, LOADMAP, combines real-time information about drivers and loads with an elaborate forecast of future loads and truck activities to maximize profits and service. It provided management with a new understanding of the economics of truckload operations; integrated load evaluation, pricing, marketing, and load solicitation with truck and load assignment; and increased profits by an estimated $2.5 million annually, while providing a higher level of service.
Effect of temperature, pH, and corneal birefringence on polarimetric glucose monitoring in the eye (2002)

Over the last two decades polarimetry has been investigated as a noninvasive alternative for glucose monitoring in support of diabetic patients. In particular, the anterior chamber of the eye containing the fluid known as the aqueous humor has been confirmed to be the optimal sensing site for polarimetric glucose measurements due to its reasonable pathlength (1 cm), low scatter, and minimal depolarization index. In essence, the eye can be thought of as an optical window into the body. In this paper, we will first introduce the key challenges that must be overcome to make the use of polarized light in the eye a viable method for noninvasive glucose monitoring, summarize our work toward this endeavor, and then report on our latest research, namely, the effect of temperature, pH, and corneal birefringence on our polarimetric glucose monitoring system.
A systematic comparison of enzymatic activity and protein interaction analysis of the KDM3 histone demethylase subfamily. (2013)

Histone modifications play an important role in chromatin organization and gene regulation, and their interpretation is referred to as epigenetic control. The methylation levels of several lysine residues in histone tails are tightly controlled, and JmjC domain-containing proteins are one class of broadly expressed enzymes catalyzing methyl group removal. However, several JmjC proteins remain uncharacterized, gaps persist in understanding substrate recognition, and the integration of JmjC proteins into signaling pathways is just emerging. The KDM3 subfamily is an evolutionarily conserved group of HDM proteins, thought to share lysine substrate specificity. Here we use a systematic approach to compare KDM3 subfamily members. We show that full-length KDM3A and KDM3B are H3K9me1/2 histone demethylases whereas we fail to observe histone demethylase activity for JMJD1C using immunocytochemical and biochemical approaches. Structure-function analyses revealed the importance of a single amino acid in KDM3A implicated in the catalytic activity towards H3K9me1/2 that is not conserved in JMJD1C. Moreover, we use quantitative proteomic analyses to identify subsets of the interactomes of the 3 proteins. Specific interactor candidates were identified for each of the three KDM3 subfamily members. Importantly, we find that SCAI, a known transcriptional repressor, interacts specifically with KDM3B. Taken together, we identify substantial differences in the biology of KDM3 histone demethylases, namely enzymatic activity and protein-protein interactions. Such comparative approaches pave the way to a better understanding of KDM specificity and protein function at a systems level and are instrumental in identifying the more subtle differences between closely related proteins.
Homodyne demodulation scheme for fiber optic sensors using phase generated carrier (1982)

A method of homodyne demodulation using a phase generated carrier is described and experimentally demonstrated. The method has a large dynamic range, good linearity, and is capable of detecting phase shifts in the microradian range. The detection scheme obviates the phase tracker resetting problem encountered in active homodyne detection schemes. Two methods of producing the carrier are presented, one employing a piezoelectric stretcher, the other using current induced frequency modulation of the diode laser source. These two methods are compared. The origins of the noise limiting the system are briefly discussed.
Photochemical reaction of ethylene with 3-chlorotetrafluoropyridine: a novel insertion into a C–Cl bond (1979)

M. G. Barlow, R. N. Haszeldine and J. R. Langridge, J. Chem. Soc., Chem. Commun., 1979, 608 DOI: 10.1039/C39790000608
Threading news video topics (2003)

We introduce a method to extract topic threads throughout a large-scale news video corpus as well as an interface that provides the users with the facility to browse through the corpus guided by the thread structure. The thread-based interface enables thorough understanding of a topic of interest, and moreover, it is designed to reduce the number of candidates provided during the tracking process which lightens the burden of selection imposed on the users. In this paper, we introduce the details of topic segmentation, tracking/threading, followed by the evaluation of the segmentation and the introduction of a prototype interface. The evaluation showed practical ability, and the trial use of the interface turned out to be effective and informative.
Couches minces de rouilles vertes sulfatées et chlorurées : Caractérisations et suivi de l'oxydation par spectroscopie UV-Visible (2006)

Conférence du 13 au 17 novembre 2006. Communication orale.
Figure S2 from Alterations in the Global Proteome and Phosphoproteome in Third Generation EGFR TKI Resistance Reveal Drug Targets to Circumvent Resistance (2023)

&lt;p&gt;Supplementary Fig S2&lt;/p&gt;
The Reservoir Engineering Aspects of Horizontal Drilling (1984)

ABSTRACT Elf Aquitaine has drilled four horizontal wells in the past five years: three on land in France are part of a research and development program with the Institut Français du Pétrole; one offshore Italy where Elf is operator for an association which includes Agip. This paper presents criteria for chosing horizontal rather than conventional wells, and gives simple analytic formulas for the productivity and water coning. Production data collected on the four wells over a period of two to four years confirms these formulas. These criteria have led us to select several new projects for horizontal drilling.
La O. M. C. Comentarios jurídico económicos para Colombia (1998)

Esta obra presenta un análisis completo de la temática del comercio internacional con sus implicaciones para Colombia, recoge los antecedentes y evolución del GATT, las consideraciones pertinentes de la Ronda Uruguay y contextualiza la O.M.C. en la actual globalización. Adicionalmente realiza un análisis detallado de sus implicaciones para Colombia y un estudio sectorial de gran actualidad.
Renewable pH Cross-Sensitive Potentiometric Heparin Sensors with Incorporated Electrically Charged H+ Ionophores (1999)

Polymer membrane-based potentiometric sensors have been developed earlier to provide a rapid and direct method of analysis for polyions such as heparin, a natural anticoagulant administered to prevent thrombus formation during cardiovascular surgery. These heparin sensors are irreversible, requiring a membrane renewal procedure between measurements which currently prevents the sensors from being used for continuous monitoring of blood heparin. A newly developed heparin sensor is shown here to allow an alternate and more practical method of membrane renewal. The electrically charged H+ ionophore 5-(octadecanoyloxy)-2-(4-nitrophenylazo)-phenol (ETH 2412) is incorporated as an additional ionophore into a heparin-sensing membrane. This membrane will respond to pH only at low H+ concentrations, while sample anions are coextracted with H+ ions into the membrane at physiological pH. In buffered samples at physiological pH, the sensors will therefore respond to heparin via an ion-exchange mechanism with chloride anions. The pH cross-sensitive heparin-sensing membranes are shown to give an excellent potentiometric response toward heparin in aqueous samples at physiological pH and Cl-levels as well as in undiluted whole blood with no loss of heparin response. The membrane renewal is accomplished by moderately increasing the pH of the sample, causing heparin to diffuse out of the membrane with H+ ions. Reproducibilities are, with less than 1 mV standard deviation, improved over the classical system. Unlike the high NaCl concentration used to strip heparin from the previously established heparin sensor, the pH change used here could ultimately be performed locally at the sample-membrane interface, allowing the sensor to be used for automated long-term monitoring of heparin in blood. A theoretical model is presented to explain the experimental results.
「衣」戀一個不膚淺的學者 : 與張小虹教授訪談 (2007)

三月上旬，嶺南大學群芳文化研究及發展部邀請了台灣大學外國語文學系的張小虹教授，出席「芳艷芬傑出中國文化研究講座2007」，她的講題是「時尚、身體、Shame 代性」。她以「現代性」與「 Shame 代性」的跨語言雙關語作為出發點，以 「恥辱作為表面」／「表面作為恥辱」的理論架構，切入當前有關「中國現代性」的研究，清末民初的男女如何透過「文明新裝」，表現了對西方文明怎樣的羨、對傳統服裝有何種的Shame，從中映出時尚的流變，與其帶來的身體經驗。我們也藉著這寶貴的機會跟張老師談談。\n自問對張老師認識不深，於是「臨急抱佛腳」地從圖書館借來《絕對衣性戀》、《在百貨公司遇見狼》等看看作準備。第一次聽張老師的演講，第一次看張老師的書，腦海裡總會想起「玩味」二字，覺得她很有創意，很有趣。她的文筆時而輕鬆，時而艱澀，時而理性，時而感性。她喜歡在俗不可耐的事物和難懂理論裡「遊走」，她的書寫不落俗套但也不會讓人似明非懂。 所以，訪問這個「貪玩」的老師，就不想以太沉重的題目 (例如學術生涯、理論)作開端，不想訪問氣氛太嚴肅。(結果也沒有讓我們失望吧!)\n一切由她最喜歡的時裝開始，談談中港台兩岸三地的服裝意識。
Micromachined printhead for the patterning of organic materials and metals (2005)

This paper describes the design, fabrication and testing of an electrostatically actuated microshutter used as an active shadow mask to pattern evaporated materials. The microshutter and its comb-drive actuator are built on the device layer of an SOI wafer. Deep reactive ion etching (DRIE) is used to pattern both the device layer and etch a through-wafer hole through which the evaporated materials travel. The actuation voltage of the device is about 30 volts, its resonant frequency is several kHz. The microshutter integrated with an x-y-z manipulator was used to print patterns of organic material and metal on glass substrates in vacuum with a resolution of 30 microns. This printing scheme could enable the patterning of large area organic optoelectronic devices on diverse substrates.
Hypervalent Iodine in Synthesis XXX: Palladium-Catalyzed Reaction of Diaryliodonium Salts with β-substituted-α, β-enones (2000)

Abstract The reaction of diaryliodonium salts with β-substituted-α,β-enones in the presence of a palladium catalyst affords Hβ-substituted products with excellent yields.
Tumoral Expression of IL-33 Inhibits Tumor Growth and Modifies the Tumor Microenvironment through CD8+ T and NK Cells (2014)

Cancer immunotherapy has shown great promise as a new standard cancer therapeutic modality. However, the response rates are limited for current approach that depends on enhancing spontaneous antitumor immune responses. Therefore, increasing tumor immunogenicity by expressing appropriate cytokines should further improve the current immunotherapy. IL-33 is a member of the IL-1 family of cytokines and is released by necrotic epithelial cells or activated innate immune cells and is thus considered a "danger" signal. The role of IL-33 in promoting type 2 immune responses and tissue inflammation has been well established. However, whether IL-33 drives antitumor immune responses is controversial. Our previous work established that IL-33 promoted the function of CD8(+) T cells. In this study, we showed that the expression of IL-33 in two types of cancer cells potently inhibited tumor growth and metastasis. Mechanistically, IL-33 increased numbers and IFN-γ production by CD8(+) T and NK cells in tumor tissues, thereby inducing a tumor microenvironment favoring tumor eradication. Importantly, IL-33 greatly increased tumor Ag-specific CD8(+) T cells. Furthermore, both NK and CD8(+) T cells were required for the antitumor effect of IL-33. Moreover, depletion of regulatory T cells worked synergistically with IL-33 expression for tumor elimination. Our studies established "alarmin" IL-33 as a promising new cytokine for tumor immunotherapy through promoting cancer-eradicating type 1 immune responses.
Disparity-based segmentation of stereoscopic foreground/background image sequences (1994)

Describes a method for displacement estimation in stereoscopic images, which is closely coupled with a segmentation of the pictures into homogeneously displaced regions. The technique is driven by a statistical optimization criterion which assesses the quality of the disparity estimate and of the segmentation, thus improving both of these simultaneously. In addition, the optimization criterion explicitly takes occluded areas into consideration. With the additional help of two constraints, this enables the algorithm to locate regions corresponding to occlusions accurately.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Electrochemical Evaluation of Corrosion Inhibiting Layers Formed in a Defect from Lithium-Leaching Organic Coatings (2017)

This work presents the electrochemical evaluation of protective layers generated in a coating defect from lithium-leaching organic coatings on AA2024-T3 aluminum alloys as a function of neutral salt spray exposure time. Electrochemical impedance spectroscopy was used to study the electrochemical properties on a macroscopic scale. An electrochemical model allowed to quantitatively link the electrochemical behavior with the physical model of the layer in the damaged area as studied by scanning electron microscopy. Local potentiodynamic polarization curves obtained from micro-cell measurements showed an increase of the passive range in the defect area due to the formation of a robust protective layer. Scanning vibrating electrode technique measurements confirmed the non-reversible long-term corrosion protection of these generated layers in the coating defect.
Metal–Organic Framework-Inspired Metal-Containing Clusters for High-Resolution Patterning (2018)

We report the preparation of discrete nanometer-scale zinc-based clusters and use them to form sub-15 nm structures by means of extreme ultraviolet lithography. By taking advantage of a metal-containing building unit derived by a metal–organic framework—MOF-2, we found the 3-methyl-phenyl-modified Zn-mTA cluster that formed is well-defined with controlled size and structure and demonstrates extremely high solubility. Progress in recent years in metal–organic frameworks has created a rich variety of metal-containing structures that are useful for numerous applications. Substitution of the bridging ligands with monovalent ligands produces a discrete metal–organic cluster that strongly interacts with soft X-rays at a wavelength of 13 nm. Here we describe the design, preparation, computational modeling, and physical characterization of these new materials. Such metal-containing structures may form the basis of photoresists that enable the next generation of microelectronic devices.
Generalized Toeplitz–Hankel matrices and their application to a layered electron gas (2021)

Abstract We extend the standard result for the eigenspectrum of the Toeplitz matrix C ij = e − κ | i − j | with 0 ⩽ i , j ⩽ N and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" overflow="scroll"> <mml:mi>κ</mml:mi> <mml:mo>∈</mml:mo> <mml:mi mathvariant="double-struck">C</mml:mi> </mml:math> to a combination of a Toeplitz matrix and a Hankel matrix. We apply this result to find the plasma modes of a layered assembly of a two-dimensional electron gas. We find a sum rule relating the geometric mean of the frequencies of the plasma modes to the determinant of this Toeplitz matrix, for which an analytical expression is obtained. We apply the same technique to the generalized case when the layers are not evenly spaced, where the corresponding matrix is not a Toeplitz–Hankel combination. Despite this fact, it is possible to find properties of the eigenspectrum, and the eigenmodes are localized to a few layers instead of extending across the system.
Effects of Short and Long-Term Soy Protein Isolate Intake on Hepatic Cytochrome P450 Expression in Obese Zucker Rats (2021)

To determine the effects feeding for 8 (short-term) and 16 weeks (long-term) soy protein isolate on hepatic CYP gene expression. 7-weeks old rats were randomly assigned to either a casein (CAS) or a soy protein isolate (SPI) diet. They were provided the diets ad libitum for 8 and 16 weeks. Rats were euthanized and livers were stored at − 80°C. RNA was extracted from liver samples, and sequenced to obtain transcriptomic data (RNAseq). Ingenuity Pathway Analysis software (IPA, Qiagen, CA) was used in the analysis of global gene expression data. This analysis includes predictions of activation or inhibition of molecules or upstream regulators and functions based on a generated z-score and p-value of overlap (P = 0.05). Z-scores were consider significant when > 2 (activation) and < −2 (inhibition). Comparing short- vs long-term feeding revealed an increase in the number of down-regulated CYP genes from only 3 at 8 weeks of SPI diet to 10 at 16 weeks of same diet (P < 0.05). In contrast, upregulated CYP gene numbers showed a small increase in long-term SPI diet compared to short-term, from 14 genes at 8 weeks to 17 genes at 16 weeks (P < 0.05). In addition, we present a predicted activation of the transcription factor Aryl hydrocarbon receptor (AHR, activation z-score = 2.146, P = 4.20E-11), linked to the subsequent activation or up-regulation of various CYPs genes, indirectly leading to the activation and inhibition of two main metabolic functions under SPI feeding: conversion of lipid (lipid metabolism) –predicted to be activated (z-score = 2.089, P = 2.77E-08), and recruitment of phagocytes (inflammatory response) –predicted to be inhibited (z-score = −2.311, P = 2.10E-05). Through global gene expression analysis we showed that gene expression of drug-metabolizing cytochrome P450 genes was modified in genetically obese Zucker rats after being fed a soy-based diet for short- and long-term, and that this change could have an important role in attenuation of liver steatosis. Further research is needed to corroborate these results. This study was supported in part by the College of Medicine's University Medical Group (RH) and the Arkansas Biosciences Institute (WB, RH).
Using log files to track students' model-based inquiry (2006)

Mechanics) to promote scientific literacy on a broad scale, namely, content knowledge, process skills, and epistemologies of science (Perkins, 1986). The process skills we focus on in this project are model-based inquiry skills; epistemological constructs of interest here are students’ epistemologies of models as a subset of epistemology of science (Gobert &amp;amp; Discenna, 1997; Schwartz &amp;amp; White, 1999). Our technological infrastructure, Pedagogica ™ (Horwitz &amp;amp; Burke, 2002) logs all students ’ interactions with our hypermodels (Horwitz &amp;amp; Christie, 1999). We use students ’ log files as performance assessments of model-based inquiry on inquiry tasks called “hot spots ” and track changes in inquiry skills over time both within and across domains. Project Overview The Modeling Across the Curriculum project is a scalability project for which we have developed a technology platform, a reporting system, and curricular materials. There are four levels of research being conducted. Level 1 is focused on improving the scaffolding design through individual interviews of students and teachers. Level 2 is focused on classroom-based studies to evaluate the impact of amount of scaffolding. Level 3 is a longitudinal study of our dependent variables (content, inquiry skills, attitudes towards science, and epistemology of models) with the same students across 3 years in all three domains in our Partner Schools. Level 4 addresses what supports are necessary to scale this to many more schools. Our curricular activities present students with content using a progressive model-building approach (White
The cystic fibrosis airway microbiome (2012)

A comprehensive understanding of airway infections offers the potential for improved disease management in CF patients. Accurate quantitative microbiology will be a prerequisite for routine intervention based on the polymicrobial perspective of CF infection exacerbations.
The stability and robustness of metabolic states: identifying stabilizing sites in metabolic networks (2007)

The dynamic behavior of metabolic networks is governed by numerous regulatory mechanisms, such as reversible phosphorylation, binding of allosteric effectors or temporal gene expression, by which the activity of the participating enzymes can be adjusted to the functional requirements of the cell. For most of the cellular enzymes, such regulatory mechanisms are at best qualitatively known, whereas detailed enzyme-kinetic models are lacking. To explore the possible dynamic behavior of metabolic networks in cases of lacking or incomplete enzyme-kinetic information, we present a computational approach based on structural kinetic modeling. We derive statistical measures for the relative impact of enzyme-kinetic parameters on dynamic properties (such as local stability) and apply our approach to the metabolism of human erythrocytes. Our findings show that allosteric enzyme regulation significantly enhances the stability of the network and extends its potential dynamic behavior. Moreover, our approach allows to differentiate quantitatively between metabolic states related to senescence and metabolic collapse of the human erythrocyte. We think that the proposed method represents an important intermediate step on the long way from topological network analysis to detailed kinetic modeling of complex metabolic networks.