gebhart/patrepeval huggingface dataset:
Innovation capability building and learning mechanisms in latecomer firms: recent empirical contributions and implications for research (2012)

This article reviews research in the past 25 years on learning processes as a source of innovation capability building in firms from developing/emerging economies, which are known as latecomers. We find that if latecomer firms make limited efforts to acquire and create the resources required to innovate, they will (1) deepen their innovative capabilities only slowly, if at all; (2) have difficulties crossing discontinuities between different levels of capability; (3) tend to remain locked into forms of ‘follower’ innovation rather than innovating as leaders. This article contributes to expanding our understanding of learning mechanisms in innovation capability building beyond the context of firms from advanced economies, and recommends areas for new research into latecomer learning and innovation capability building. Résumé Cette étude examine la recherche menée dans les 25 dernières années sur les processus d'apprentissage comme une source d'innovation au sein des sociétés des économies émergentes, ou bien, les entrants tardifs. Nous observons que si ces sociétés investissent peu dans l'innovation, elles vont : (1) limiter leur capacité d'innover, (2) rencontrer des difficultés quant à la gestion des différents niveaux de capacité et (3) vont devenir des acteurs passifs et non des leaders d'innovation dans leur domaine. Ce travail contribue à notre compréhension des mécanismes d'apprentissage entraînant la capacité d'innovation au delà du domaine d'économies avancées afin de recommender que plus de recherche soit menée pour traiter des les entrants tardifs et leurs capacités d'innovation.
Statistical approach to analysis of electrohysterographic signal (2003)

The intensity of contraction of the pregnant uterus expressed by intrauterine pressure depends on the quantity of contractile cells being activated at a time. Their electrical activity creates differences of potentials known as electrohysterogram (EHG). The abdominal electrohysterogram can be an alternative to the tocography tool, which is useful in clinical evaluation of the pregnant uterus activity. We describe a procedure for analysis of EHG signal. It performs the running estimation of the ratio of standard deviation to mean value in the signal provided and semi-automatically detects segments of signal corresponding to periods of increased uterine activity. The power carried by the signal in specified frequency band is estimated, which enables power spectrum density tracking for consecutive contractions.
La salud como expresión de las diferencias urbano-rurales en América Latina (1986)

Les resultats obtenus mettent en evidence des differences urbano-rurales en ce qui concerne la sante maladie et le desavantage de la campagne par rapport a la ville
Occurrence and clinical features of sensitization to Pityrosporum orbiculare and other allergens in children with atopic dermatitis. (1995)

One hundred and nineteen consecutive cases of children with atopic dermatitis aged 4-16 years (73 girls) from a pediatric dermatology outpatient clinic were included in a study of atopic sensitization. Structured interviews and clinical investigations were performed. IgE antibodies to common inhalant allergens, Pityrosporum orbiculare, Candida albicans, Tricophyton rubrum and Staphylococcus aureus were detected. Specific IgE antibodies frequently occurred to pollens, animal epithelia, C. albicans, house dust mites and moulds, whereas specific IgE antibodies to potential skin allergens were less prevalent. Twenty-six children (21.8%) had IgE antibodies to P. orbiculare, 14 (11.8%) to T. rubrum and 3 (2.5%) to S. aureus. Atopic dermatitis in children with one or several RAST positivities was worse, with a more chronic course, higher total eczema score, more frequent distribution in the head-neck-face regions and more itch compared to the children without serum detectable IgE antibodies. Severe itch disturbing nightly sleep was the only clinical feature that characterised P. orbiculare-positive cases. Allergy to P. orbiculare appears to be of little importance in early childhood atopic dermatitis but is likely to carry a poor prognosis.
GENETIC VARIATION OF PHENOLIC COMPOUNDS CONTENT, ESSENTIAL OIL COMPOSITION AND ANTI OXIDATIVE ACTIVITY IN ISRAEL-GROWN MENTHA LONGIFOLIA L. (2006)

ISHS I International Symposium on Natural Preservatives in Food Systems GENETIC VARIATION OF PHENOLIC COMPOUNDS CONTENT, ESSENTIAL OIL COMPOSITION AND ANTI OXIDATIVE ACTIVITY IN ISRAEL-GROWN MENTHA LONGIFOLIA L.
Mechanisms in Allergic Contact Dermatitis (2001)

During the past few decades, our understanding of why, where, and when allergic contact dermatitis (ACD) might develop has rapidly increased. Critical discoveries include the identification of T cells as mediators of cell-mediated immunity, their thymic origin and recirculation patterns, and the molecular basis of their specificity to just one or few allergens out of the thousands of allergens known. Progress has also resulted from the identification of genes that determine T-cell function, and the development of monoclonal antibodies that recognize their products. Moreover, the bioindustrial production of large amounts of these products, e.g. cytokines, and the breeding of mice with disruptions in distinct genes (knock-out mice) or provided with additional genes of interest (transgenic mice), have allowed in-depth analysis of skin-inflammatory processes, such as those taking place in ACD.
N,N,N′,N′-Tetramethyl-N′′,N′′-dipropylguanidinium chloride–(2Z)-2,3-diaminobut-2-enedinitrile (1/1) (2012)

In the crystal structure of the title compound, C(11)H(26)N(3) (+)·Cl(-)·C(4)H(4)N(4), the (2Z)-2,3-diamino-but-2-ene-dinitrile (Z-DAMN) mol-ecules are connected with the chloride ions via N-H⋯Cl hydrogen bonds, forming ribbons running along the a axis. The guanidinium ions are located in between the ribbons formed by Z-DAMN mol-ecules and chloride ions.
Cell‐mediated immune response of goldfish, Carassiusaurafus (L.), to Ichthyophthirius multifiliis (1996)

Abstract Goldfish, Carassius auratus (L.), were intraperitoneally injected with two doses of Ichthyophthirius multifiliis (each containing 2.3 × 10 6 live tomites) in saline, 30 days apart. The control fish were injected with saline only. Two weeks after the last vaccination, fish of both groups were intradermally injected with 2.5 × 10 5 live tomites for skin tests. The skin at the antigen‐injected site of the vaccinated fish increased in thickness from 8 h onwards and reached a peak at 24 h. Histological study showed a heavy infiltration of mononuclear leucocytes at the antigen‐injected site. In contrast, no such changes were encountered in control fish. The migration area of pronephros cells from the vaccinated fish was significantly inhibited, in vitro , compared to controls with the presence of antigens. These findings suggest that the tomite‐vaccinated fish produced a cell‐mediated immune response. However, vaccinated fish also exhibited significantly higher titres of immobilizing antibodies in their sera and mucus than the controls. Therefore, it is likely that both humoral and cell‐mediated immune responses have to work closely together to eliminate the infectious tomites of I. multifiliis which succeed in penetrating the fish epithelial tissues.
ChemInform Abstract: Synthesis of New Potentially Analgesically and Antibiotically Active Pyridazino(4,3‐e)(1,3)oxazinones and Pyrimido(4,5‐c)pyridazinones. (1989)

Abstract The carboximidoyl chlorides (III) are hydrolyzed and then cyclized, forming the pyridazinooxazinones (IV).
Integrated Research/Education University Aircraft Design Program Development (2017)

Abstract : The two major goals of AFOSR Grant FA9550-14-1-0027, Integrated Research/Education University Aircraft Design Program Development, were (a) to contribute to the development cutting edge capstone airplane design courses in U.S. universities. Such courses would take advantage of the most recent developments in software and hardware systems and tools as well as systems design technology to bring into aerospace engineering undergraduate and graduate programs a systems integration perspective and the experience of designing, building, and flying, supported by rigorous analysis and tests, of advanced research unmanned aerial vehicles (UAVs); (b) to contribute to the understanding of design options and tradeoffs that would lead to efficient long-range supersonic aircraft without tail surfaces. No tail surfaces or reduced size tail surfaces may lead to less drag, less weight, lower construction cost, and smaller stealth signatures. The elimination or size-reduction of tail surfaces must be well understood regarding the impact on flight stability and control, especially at low-speed takeoff, approach and landing conditions, and in the context of thorough multidisciplinary optimization that would account for all design criteria, constraints, and objectives. New contributions to tailless or minimal-tail supersonic long-range flight are of importance to the future of both military and civil aircraft.
Expression of A and B subunits of Shiga-like toxin II as fusions with glutathione S-transferase and their potential for use in seroepidemiology (1993)

We used the plasmid vector pGEX-2T for the expression of recombinant subunits of Shiga-like toxin II (SLT-II). The 5' terminus of the genes that code for either the SLT-IIA or SLT-IIB subunits was genetically fused to the 3' terminus of the gene coding for the enzyme glutathione S-transferase, which serves as a carrier in this expression system. The subunit genes were constructed synthetically by polymerase chain reaction, with appropriate restriction sites to permit in-frame downstream insertion of the genes. The resulting plasmids containing the A and B subunit genes were designated pFG1 and pFG2, respectively. Induction of Escherichia coli laboratory strains harboring pFG1 with isopropyl-beta-D-thiogalactopyranoside (IPTG) yielding only small quantities of SLT-IIA fusion proteins. Since IPTG induction was lethal for cells harboring pFG2, we constructed the recombinant plasmid pFG4, which contained a subgenic fragment of slt-IIB but without the 5' signal sequence. With this construct we were able to express very large quantities of a 33.5-kDa fusion protein, which was purified by affinity chromatography on immobilized glutathione and used as an antigen in immunoblot analysis. Rabbit serum against native SLT-II, as well as all of 12 serum samples with high neutralizing activity against SLT-II, reacted with SLT-IIB purified from an E. coli pFG4 expression system, whereas only 3 of 208 human serum samples with low neutralization titers and none of 54 serum samples with no SLT-II-neutralizing capability reacted. Failure of specific reactivity with the SLT-IIB fusion protein in the majority of human serum samples with low neutralizing activity suggests that serum factors other than immunoglobulins may be responsible for neutralizing activity in these cases. The immunoblot assay with recombinant SLT-IIB as the antigen can be recommended for use in a diagnostic setting as a simple and reliable approach to detect specific human serum antibodies to SLT-II.
Behavioral effects and binding affinities of two stereoisomeric psychotomimetic glycolates (1976)

A comparison was made of the behavioral effects in cats of the dextro and levo isomers of 3-quinuclidinyl benzilate (QB), using a special computer-controlled program. Such psychophysical parameters as rate of response and tendency to use the left or right paw for lever pressing were used primarily to evaluate drug efficacy. The drug did not alter auditory threshold or the percentage of errors in lever pressing. The l-isomer was found to be at least 100 times as potent as the d-isomer, the effects of both being qualitatively similar. After a single dose of 5 mug/Kg of 1-QB, the cats' performance did not return to normal until 5-7 days later. Pretreatment of the cats with a dose of 2 mg/Kg of atropine, an antimuscarinic agent, did not prevent the behavioral effects of 1-QB. The binding affinity of two isomers for synaptic membranes and phosphatidyl serine was identical.
SGN228-001: A phase I open-label dose-escalation, and expansion study of SGN-CD228A in select advanced solid tumors. (2020)

TPS3652 Background: SGN-CD228A is an investigational antibody-drug conjugate (ADC) that targets CD228, a cell-surface oncofetal protein with prevalent expression in several types of cancer and limited expression on normal tissues. SGN-CD228A consists of a humanized IgG1 anti-CD228 monoclonal antibody conjugated to an average of 8 molecules of monomethyl auristatin E (MMAE) via a PEGylated β-glucuronidase cleavable linker. MMAE is a well-studied and highly active chemotype with an established safety profile. The proposed mechanism of action involves binding CD228 on cell surfaces, ADC internalization, and trafficking to lysosomes. MMAE is then released through β-glucuronidase cleavage of the glucuronide MMAE linker. MMAE then binds tubulin, which disrupts microtubule networks and causes cell cycle arrest and apoptosis. Methods: SGN228-001 (NCT04042480) is a phase 1, open label, multicenter, dose escalation, and expansion study enrolling up to 240 subjects to evaluate the safety, tolerability, PK, and antitumor activity of SGN-CD228A in select advanced solid tumors. Eligible subjects are ≥18 years of age and have metastatic cutaneous melanoma, malignant pleural mesothelioma, human epidermal growth factor receptor 2-negative metastatic breast cancer, advanced non-small cell lung cancer, metastatic colorectal cancer, or advanced pancreatic ductal adenocarcinoma. Subjects must have relapsed, refractory, or progressive disease, and should have no appropriate standard therapy available. Measurable disease per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1), Eastern Cooperative Oncology Group (ECOG) performance status score of ≤1, and adequate renal, hepatic, and hematologic function are required. The study includes dose escalation and dose expansion, with multiple disease-specific dose expansion cohorts and a biology cohort. Dose escalation will be conducted using the modified toxicity probability interval method (Ji 2010) to evaluate the safety and identify the maximum tolerated dose of SGN-CD228A. Following dose escalation, disease-specific expansion cohorts and a biology cohort (to evaluate exploratory biomarkers) are planned. Response assessments will be conducted every 6 weeks per RECIST v1.1 and all subjects will be followed for safety. Pharmacokinetics and markers of pharmacodynamics will be assessed regularly. Key efficacy endpoints include objective response rate, progression-free survival, and duration of objective response. Enrollment is ongoing in the US and planned in Europe. Clinical trial information: NCT04042480 .
[Journal First] Do Automated Program Repair Techniques Repair Hard and Important Bugs? (2018)

The full version of this article is: Manish Motwani, Sandhya Sankaranarayanan, Rene Just, and Yuriy Brun, Do Automated Program Repair Techniques Repair Hard and Important Bugs? in Empirical Software Engineering, http://dx.doi.org/10.1007/s10664-017-9550-0
Localization using infrared beacons (2000)

In this paper, we deal with a localization system allowing one to determine the position and orientation of a mobile robot. This system uses active beacons distributed at the ceiling of the navigation area. These beacons can transmit a coded infrared signal which allows the robots to identify the sender. A CCD camera associated to an infrared receiver allows one to compute the position with a triangulation method which needs reduced processing time. Calibration and correcting distortion stages are performed to improve accuracy in the determination of the position. Dynamic localisation is established for most actual mobile robots used in indoor areas.
Effects of Rhenium(I)-diselenoether and of its Diselenide Ligand on the Production of Cathepsins B and S by MDA-MB231 Breast Malignant Cells (2021)

To the best of our knowledge, this is the first demonstration that Re-diSe may decrease the production of cathepsins B and S in cancer cells at doses as low as 10 μM.
Alteration of Theophylline Clearance and Half-life by Cimetidine in Normal Volunteers (1981)

Interaction between cimetidine and theophylline was studied in six male volunteers, who were randomly divided into two groups to eliminate temporal effects. The effect of cimetidine on theophylline elimination was immediate and progressed as cimetidine treatment was continued. Cimetidine prolonged theophylline half-life compared to that in control periods an average of 36.2% (range, 0 to 103%) on the first day of cimetidine exposure (p less than 0.05). Theophylline clearance was decreased an average of 18.5% (range, 4.9% to 36%), whereas theophylline volume of distribution was unchanged by cimetidine. After 8 days of cimetidine treatment at the usually recommended dosage, theophylline half-life further increased to 64.3% (range, 9% to 128%) of control values, whereas clearance declined an average of 30% (range, 5% to 50%) (p less than 0.01). Theophylline volume of distribution remained unchanged. Although cimetidine-theophylline interaction needs confirmation in a patient population, we advise caution when these agents are coadministered. Some adjustment in theophylline dosage may be needed in treated patients who are also given cimetidine, and these patients who are also given cimetidine, and these patients should be studied closely with theophylline serum concentration measurements and careful clinical assessments.
White Blood Cell Count and Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention in the Contemporary Era (2017)

URL: http://www.clinicaltrials.gov. Unique identifier: NCT00998127.
Inhibition of Cyclin-Dependent Kinases - A Review of the Recent Patent Literature (2006)

The cyclin dependent kinases, Cdks, are potential targets for new anticancer therapy. Dysregulation of the cell cycle is common during tumorigenesis, and inhibition of certain Cdks has been shown to inhibit tumor cell growth, induce apoptosis and cause tumor regressions in animal models. This review discusses the rationale for inhibiting Cdks as an approach to cancer therapy and the status of Cdk inhibitors in clinical trials. Compounds resulting from a patent literature search from 2003 to July, 2005 are discussed.
Targeting Akt in cancer therapy (2007)

In an effort to improve therapeutic options in cancer, many investigational drugs are being developed to inhibit signaling pathways that promote the survival of cancer cells. The prototypic pathway that promotes cellular survival is the phosphoinositide 3'-kinase/Akt/mammalian target of rapamycin pathway, which is constitutively activated in many types of cancers. Mechanisms for activation of the serine/threonine kinase, Akt, include loss of tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) function, amplification or mutation of phosphoinositide 3'-kinase, amplification of Akt, activation of growth factor receptors and exposure to carcinogens. Activation of Akt promotes cellular survival as well as resistance to treatment with chemotherapy and/or radiation therapy. Immunohistochemical analyses have shown that Akt is activated in many types of cancers and preneoplastic lesions, and Akt activation is a poor prognostic factor in various cancers. Taken together, these data demonstrate that Akt is a valid target for inhibition. This review will focus on published data using different approaches to inhibit Akt. We will also consider how the complex regulation of the phosphoinositide 3'-kinase/Akt/mammalian target of rapamycin pathway poses practical issues concerning the design of clinical trials, potential toxicities and the likelihood of finding a therapeutic index when targeting such a critical cellular pathway.
Modeling and Predicting Selected Immunological Effects of a Chemical Stressor (3,4-Dichloropropionanilide) Using the Area under the Corticosterone Concentration versus Time Curve (2000)

Many chemicals and drugs can induce a neuroendocrine stress response that can be immunosuppressive. Mathematical models have been developed that allow prediction of the immunological impact of such stress responses in mice on the basis of exposure to the important stress-related mediator corticosterone. The area under the corticosterone concentration vs. time curve (AUC) has been used as an indicator of cumulative corticosterone exposure in these modeling studies. In the present study, an immunotoxicant known to induce a stress response, 3,4-dichloropropionanilide (propanil), was evaluated to determine if corticosterone AUC values are related to suppression of immunological parameters in mice treated with this chemical. Linear relationships between corticosterone AUC values and suppression of the following parameters were noted in B6C3F1 female mice: thymus cellularity and thymus subpopulation percentages, splenic subpopulation percentages, natural killer cell activity, MHC class II protein expression, and IgG1 and IgG2a antibody responses to antigen. Linear models derived in previous studies using mice treated with exogenous corticosterone or with restraint stress effectively predicted the immunological effects of 3, 4-dichloropropionanilide on the basis of corticosterone AUC values. The models derived using immobilization stress were more effective (r(2) for observed vs. predicted = 0.90) than the models derived using mice treated with exogenous corticosterone (r(2) for observed vs. predicted = 0.65). This was expected, because most stressors induce a variety of immunomodulatory mediators, not just corticosterone. These findings have implications for risk assessment in immunotoxicology.
American Delirium Society 2022 Year in Review: Highlighting the Year’s Most Impactful Delirium Research (2023)

The diversity of studies presented for the 2022 ADS year-in-review session illustrates the breadth of the delirium field and the growing number of clinical trials. The dissemination of publications across a broad, diverse array of journals provides further justification of the need for delirium-specific journals.
Rapid Computation Of Permeability From Micro-CT Images On GPGPUs (2018)

Summary Digital rock physics (DRP) is a rapidly evolving technology targeting fast turnaround times for repeatable core analysis and multi-physics simulation of rock properties. We develop a rapid and scalable distributed-parallel single-phase pore-scale flow simulator for permeability estimation on real 3D pore-scale micro-CT images using a novel variant of the lattice Boltzmann method (LBM). The LBM code implementation is designed to take maximum advantage of distributed computing on multiple general-purpose graphics processing units (GPGPUs). We describe and extensively test the distributed parallel implementation of an innovative LBM algorithm for simulating flow in pore-scale media based on the multiple-relaxation-time (MRT) model. The novel contributions of this work are (1) integration of mathematical and high-performance computing components together with a highly optimized implementation and (2) quantitative results with the resulting simulator in terms of robustness, accuracy, and computational efficiency for a variety of flow geometries including various types of real rock images. We report on extensive tests with the simulator in terms of accuracy and provide near-ideal distributed parallel scalability results on large pore-scale image volumes that were largely computationally inaccessible prior to our implementation. Permeability estimation results are provided on large 3D binary microstructures including real rocks from various sandstone and carbonate formations. We quantify the scalability behavior of the distributed parallel implementation of MRT-LBM as a function of model type/size and the number of utilized new-generation NVIDIA V100 GPGPUs for a panoply of permeability estimation problems.