gebhart/patrepeval huggingface dataset:
41-LB: Lipoprotein Subfractions Are Associated with Diabetic Microvascular Disease among 9,795 Patients in the FIELD Trial (2019)

Background: In the FIELD trial, a 5-year randomized double-blind placebo-controlled trial of fenofibrate vs. placebo in 9,795 adults with type 2 diabetes (T2D), the only standard lipid parameter correlating with microvascular (renal) events was triglycerides. Given the high prevalence of diabetic microangiopathy, we explored associations between lipoprotein subfractions and nephropathy, retinopathy, microvascular amputations (MiAmp) and neuropathy. Methods: We performed ultracentrifugation using the vertical autoprofile (VAP, Atherotech) on plasma (baseline and after 6 weeks of fenofibrate). Analyses were performed using Cox proportional hazards and logistic regression for new on-study events. Results were adjusted for gender and fenofibrate or placebo allocation. Results: HDL related analytes (HDL-C, HDL3-C, apo A1, apoA2) correlated with reduced risk for neuropathy, nephropathy, and MiAmp. Buoyant LDL (LDL1-C) and densest LDL (LDL4-C) correlated negatively with neuropathy and positively for MiAmp, respectively. Triglycerides and apo C3 increased neuropathy and nephropathy risk. VLDL species correlated with increased MiAmp and retinopathy risk. Conclusions: VAP identifies multiple lipoprotein subclasses and VAP subclass/apoprotein ratios associated with diabetic microangiopathy. Many were improved with fenofibrate. Disclosure P.P. Toth: Consultant; Self; Amarin Corporation, Amgen Inc., AstraZeneca, Kowa Pharmaceutical Europe Co. Ltd., Novo Nordisk Inc. Speaker’s Bureau; Self; Amarin Corporation, Amgen Inc., Merck &amp; Co., Inc., Novo Nordisk Inc., Regeneron Pharmaceuticals, Sanofi US. A.C. Keech: None. A.S. Januszewski: None. R.L. OConnell: None. L. Li: None. D. Sullivan: None. M. Taskinen: Advisory Panel; Self; Novo Nordisk A/S. Consultant; Self; Akcea Therapeutics, Chiesi USA, Inc. Research Support; Self; Amgen Inc., Novo Nordisk A/S. Speaker’s Bureau; Self; Amgen Inc. P.L. Drury: None. G.F. Watts: None. J.D. Best: Consultant; Self; Abbott. J. Ansquer: Research Support; Self; Abbott, Mylan. S.R. Jones: None. A.J. Jenkins: Advisory Panel; Self; Abbott, Australian Diabetes Society, Medtronic. Research Support; Self; Abbott, GlySens Incorporated, Medtronic, Mylan. Speaker’s Bureau; Self; Eli Lilly and Company, Novo Nordisk Inc.
Human Performance Following Antihistamine Administration (1990)

Abstract : The objective of this research was to evaluate the effects of two antihistamines on a range of cognitive performances. Diphenhydramine was chosen because of its purported nervous system effects, while terfenadine was chosen because of its purported lack of similar effects. Six male subjects were trained on the nine task Naval Medical Research Institute Performance Assessment Battery (NMRIPAB) until performance accuracy was at least 90% for three consecutive sessions. They were subsequently administered either 60 mg of terfenadine, 100 mg of diphenhydramine, or placebo in a mixed order. Each condition was replicated three times. NMRIPAB sessions were conducted 1 hour, 2 hours, and 3 hours post drug administration. Diphenhydramine produced selective decreases in the accuracy of responding on five of the nine NMRIPAB tasks. It also produced increases in response latency in two of the nine tasks. The majority of diphenhydramine effects occurred during the second or third hour of testing, which is in conformance with the reported pharmacokinetics of the compound. Terfenadine did not produce consistent effects on any task. Each subject exhibited differing patterns of task sensitivity to diphenhydramine administration.
Synthesis of 2-aminofurans and 2-unsubstituted furans via carbenoid-mediated [3 + 2] cycloaddition (2012)

An efficient dual synthetic manifold for 2-aminofurans and 2-unsubstituted furans has been developed. The carbenoid-mediated [3 + 2] cycloaddition of copper carbenoids with enamines provides 2-amino-2,3-dihydrofurans which serve as common intermediates for both 2-aminofurans and 2-unsubstituted furans.
Efficacy testing for oral appliance therapy in obstructive sleep apnea (2021)

<b>Introduction:</b> Oral appliance therapy (OAT) is a treatment option for patients with mild-moderate obstructive sleep apnea (OSA) intolerant to positive pressure therapy. Current guidelines recommend objective follow-up testing for OAT with polysomnography or home sleep studies. (Ramar, K et al.&nbsp;J Clin Sleep Med. 2015) <b>Aim:</b> Given the lack of high-quality evidence, we sought to describe the current practices regarding follow-up testing and changes in treatment strategies&nbsp;due to&nbsp;test results in our institution. <b>Methods:</b> We performed a chart review of OSA patients evaluated for OAT in 2019. We obtained patient information, follow-up testing strategy, and outcomes regarding further titration of the OAT or transition to other treatment strategies. <b>Results:</b> We screened 226 patients and included 182 patients in the study. The main reasons for exclusion were lack of OSA diagnosis (AHI &lt;5), intolerance to OAT, and transfers. During the study period, 65 patients did not receive planned follow-up testing after OAT initiation, and 15 patients had no plans for follow-up testing determined by their Sleep medicine clinician. 103 patients received follow-up testing, with WatchPAT (67%, 70 tests) and oximetry (28%, 30 tests) being the most common strategies. Follow-up testing resulted in further titration of the OA or change in treatment strategy for 37 patients (36%), including 11 patients abandoning OAT. <b>Conclusion:</b> Most patients treated with OAT received follow-up testing, most frequently with home sleep studies.&nbsp;Over one-third of patients receiving follow-up testing ultimately receive further titration of OAT or transition to a different treatment strategy. Objective testing assessment of OAT response&nbsp;is often&nbsp;warranted.
Focus on Experiential Education: A Freshman Engineering Program in Biological Engineering* (2006)

This paper describes a freshman engineering program implemented in the Biological Engineering curriculum at Louisiana State University. This program was initiated to address low student retention rates and was subsequently modified to address new evaluation criteria and a university focus on writing across the curriculum. Our model includes the drawing, design, and construction of hands-on, group projects, and requires frequent use of oral, written, and teaming skills. Results show that retention and graduation rates have improved, and that the program is considered successful by virtue of student assessment, exit interviews, and faculty reflections. © 2006 TEMPUS Publications.
A neural network approach for the detection of the locking position in RFX (2003)

Recently in RFX, where wall locked modes were always present, a new technique has demonstrated the possibility to induce a continuous rotation of the modes with respect to the wall. In this technique the nonlinear coupling of the m=0 and m=1 modes has been used to decouple the modes themselves. In the present experiments the mode rotation is induced with a preprogrammed waveform of a toroidal magnetic field rotating ripple. A feedback system able to create a continuous rotation with variable and increasing speed is now under implementation. A neural network (NN) has been developed to identify the locked mode position. In the paper different NNs are presented, discussed and compared.
Breaching and Entering: When Data Scraping Should Be a Federal Computer Hacking Crime (2015)

The Computer Fraud and Abuse Act (CFAA) is a federal statute designed to combat computer hacking. The Act proscribes accessing data without authorization. Federal circuits have interpreted “authorization” both broadly and narrowly, resulting in a circuit split. Whereas the First, Fifth, and Eleventh Circuits have held that misuse of computer access can constitute hacking under the CFAA, the Fourth and Ninth Circuits have held that scrapers must circumvent a code or technical barrier in order to satisfy the CFAA’s mens rea requirement. This note focuses on the conduct of data scrapers. Scrapers are computer programs that aggregate data from various websites in order to present the data to users in easily readable formats. Because scrapers can be both beneficial and harmful to the digital ecosystem, this note proposes that the term “authorization” should be construed narrowly in the context of scraping. As such, CFAA liability should only be triggered when scrapers are used to circumvent code barriers and harm the sources from which they collect data. Applying this code-based rule to authorization will align with the statute’s original purpose to combat computer fraud and will not unnecessarily expose beneficial scraper users to federal criminal liability.
Microwave tomography: an algorithm for cylindrical geometries (1987)

The letter presents an efficient algorithm in cylindrical coordinates for microwave diffraction tomography. In comparison with algorithms in cartesian co-ordinates, the mechanical rotation of the object is avoided and higher-quality images are obtained with similar processing time.
Guest Editorial Special Section on Wheeled Mobility (1996)

OBILITY provides several important milestones in life. M Parents anxiously await their child’s ability to crawl and then wait impatiently to see their child’s first steps. The child then goes on to run. As a natural part of evolution, people begin to explore their environment. This exploration may include the home, the neighborhood, and the community. Mobility plays an important role in the lives of people with disabilities. The first wheelchair can represent a change from walking or the first opportunity for functional mobility. Later in life, the automobile becomes an important sign of maturity and freedom. Driving a personal automobile provides a degree of self-direction and autonomy which is nearly unparalleled. This special issue draws together several areas of personal mobility for people with disabilities. This issue includes papers related to wheelchair design and analysis, analysis of personal transportation designed for wheelchair users, factors influencing secondary disability, and evaluation of accessible environments. The common theme is the goal of providing maximum independent mobility to the widest possible range of environments over a lifetime free from a debilitating secondary disability. We hope that people will gain from this effort and will be motivated to continue or expand research into wheeled mobility. Publisher Item Identifier S 1063-6528(96)07475-7 A great number of people were involved in making this issue possible. We would like to thank D. Chesney and P. Stankovic for helping to process the reviews, H. F. Machiel Van der Loos, Ph.D., who helped to edit and process the reviews of several of the manuscripts, and R. Robinson who helped us pull the issue together. We would also like to thank the reviewers who worked very hard to give us timely and accurate reviews of each manuscript. Their work has improved the manuscripts and this special issue. This issue presents some very important advancements made in mobility research over the past decade. We hope that progress will continue at a rapid pace and that people with disabilities will continue to benefit from this important research.
Ultrasound-guided photoacoustic imaging: current state and future development (2014)

Photoacoustic imaging, frequently coregistered with ultrasonic imaging, can provide functional and cellular/molecular information about tissue within the anatomical landmarks of an imaged region. This review details the fundamentals of photoacoustic imaging and its most promising imaging applications. Particular attention is paid to photoacoustic imaging's relationship with ultrasound, focusing on distinct differences and similarities between the two modalities and highlighting the mutual benefit of using both concurrently in certain preclinical and clinical applications. Much like its origins as an imaging modality were intertwined with ultrasonic imaging (namely, its acoustic transducers and hardware), the future of photoacoustic imaging-particularly in the clinical arena-similarly depends on ultrasound and its time-tested ability to provide real-time visualization of soft tissue.
Cowpox virus CrmA, Myxoma virus SERP2 and baculovirus P35 are not functionally interchangeable caspase inhibitors in poxvirus infections (2004)

Cowpox virus (CPV) expresses the serpin (serine proteinase inhibitor) CrmA, an anti-inflammatory, anti-apoptotic protein required for production of red pocks on chicken chorioallantoic membranes (CAMs). In vitro, CrmA inhibits several caspases and granzyme B. Altering the critical P1-aspartate in the CrmA reactive centre loop to alanine resulted in a virus (CPV-CrmA-D303A) that resembled CPV deleted for CrmA (CPVDeltaCrmA : : lacZ); on CAMs it produced white, inflammatory pocks with activated caspase-3 and reduced virus yields, suggesting that CrmA activities are mediated via proteinase inhibition. CrmA in CPV was replaced with SERP2 from Myxoma virus (MYX) or baculovirus P35, which inhibit similar proteinases in vitro. SERP2 and P35 each blocked caspase-3-mediated apoptosis but were unable to control inflammation of CAMs. However, SERP2 and P35 restored virus yields, indicating that the decreased virus titres seen with CPVDeltaCrmA : : lacZ resulted from apoptosis rather than inflammation. To compare the activities of CrmA and SERP2 further, rabbits were infected with MYX recombinant viruses. Intradermal infection of rabbits with MYX was uniformly lethal, generating raised primary lesions and many secondary lesions. In contrast, deletion of SERP2 from MYX (MYXDeltaSERP2 : : lacZ) caused little mortality and produced flat primary lesions with few secondary lesions. Replacement of SERP2 with CrmA (MYXDeltaSERP2 : : CrmA) resulted in partial complementation with flat primary lesions, many secondary lesions and death in 70 % of the rabbits. Therefore, CrmA and SERP2 were not functionally interchangeable during infection of CAMs or rabbits, implying that these serpins have activities that are not evident from biochemical studies with human caspases.
[A treatment concept using external transfixation in unstable defect trauma of the knee joint]. (1989)

The main problems in the treatment of severe knee injuries with extensive soft tissue damage, ligamentary lesions and compound fractures consist in the high risk of infection and complex instability of the joint. 20 patients suffering such type of trauma were treated by a schedule comprising an extensive debridement and a combination of minimal internal osteosynthesis and external transfixation. Secondary operations were always performed as a second look in all patients and various surgical reconstructions of the soft tissue coverage under continuous protection of the external fixation. Most patients obtained satisfactory functional results, only 2 cases ended up with arthrodesis due to deep infection.
Evidence for the Rapid Onset of Apoptosis in Medial Smooth Muscle Cells After Balloon Injury (1997)

As early as 30 minutes after balloon injury, myocytes appear to undergo apoptotic cell death at a high frequency as shown by TUNEL staining, chromatin condensation, and the appearance of morphological features in electron micrographs. The induction of apoptosis coincides with a marked downregulation of bcl-X expression.
Adaptive Sampling and Routing in a Floodplain Monitoring Sensor Network (2006)

We describe the design of a flood warning system which uses a set of sensor nodes to collect readings of water level and a grid-based flood predictor model developed by environmental experts to make flood predictions based on the readings. The reporting frequency of sensor nodes is required to be adaptive to local conditions as well as the flood predictor model to optimize battery consumption. We therefore propose an energy aware routing protocol which allows sensor nodes to consume energy according to this need. This system is notable both for the adaptive sampling regime and the methodology adopted in the design of the adaptive behavior, which involved development of simulation tools and close collaboration with environmental experts
The Configuration of Random Polypeptide Chains. II. Theory (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Configuration of Random Polypeptide Chains. II. TheoryDavid A. Brant and Paul J. FloryCite this: J. Am. Chem. Soc. 1965, 87, 13, 2791–2800Publication Date (Print):July 1, 1965Publication History Published online1 May 2002Published inissue 1 July 1965https://pubs.acs.org/doi/10.1021/ja01091a003https://doi.org/10.1021/ja01091a003research-articleACS PublicationsRequest reuse permissionsArticle Views603Altmetric-Citations372LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SPIDER: ML Applied to 5G Network Cyber Range (2021)

The 5G mobile network infrastructure is highly related to the latest virtualisation technology, which exposes it to new cyber-attack vectors. Thus, there is a growing need to train cybersecurity experts in the use of appropriate tools to prevent attacks on mobile networks. To meet this need, there are systems called cyber range, among them SPIDER is specially oriented to train experts in cybersecurity with mobile networks such as 5G. In this paper we are going to indicate how to integrate a module with ML tools in SPIDER cyber range, how it works and how it can be used to train new experts.
Speech-analysis-based devices for diagnosis and education of speech and hearing impaired people (2005)

Two autonomous low cost devices which extract in real time some parameters of the voice, and perform a visual representation on a screen, are here described. Even though they can be useful in any voice related activity, they are in use at the moment in speech teaching to deaf people with good results. The first one, called SAS, displays a cross-section of the vocal tract and is based on the method proposed by Wakita (1); while the second one, named ISO-TON, makes a representation along the time of whether intensity, voiced/fricative condition of the voice, and fundamental tone.
Application of electrically peaking hybrid (ELPH) propulsion system to a full-size passenger car with simulated design verification (1999)

An electrically peaking hybrid electric (ELPH) propulsion system is being developed that has a parallel configuration. A small engine is used to supply power approximately equal to the average load power. The operation of the engine is managed by a vehicle controller and an engine controller such that the engine always operates with nearly full load-the optimal fuel economy operation. An induction motor is used to supply the peaking power required by the electrically peaking load. The motor can also absorb the excess power of the engine while the load power is less than the peak. This power, along with the regenerative braking power, can be used to charge the batteries on board to maintain the battery state-of-charge (SOC) at a reasonable level. With the electrically peaking principle, two control strategies for the drive train have been developed. One is called maximum battery SOC control strategy, by which the engine and electric motor are controlled so that the battery SOC is maintained at its top level as much as possible. This control strategy may be used in urban driving in which accelerating and decelerating driving is common and high-battery SOC is absolutely important for normal driving. The other control strategy is called engine turn-on and turn-off control by which the engine is controlled to operate in a turn-on and turn-off manner. This control strategy may be used in highway driving. Based on the ELPH principle and the drive train control strategies, a drive train for a full-size five-seat passenger car has been designed and verified using the V-ELPH computer simulation package.
Tumbling and spinning diffusions of acetonitrile in water and organic solvents (2000)

The spin–lattice relaxation times T1 for H2 and N14 of acetonitrile-d3(CD3CN) are measured in pure liquid, n-hexane, carbon tetrachloride, acetone, methanol, water, and heavy water as functions of temperature and concentration. From the T1 values, the rotational diffusion coefficients for the tumbling and spinning motions are separately obtained. The tumbling motion is strongly dependent on the solvent and temperature and its diffusion coefficient is qualitatively explained by a simple dielectric friction model. The spinning motion is, on the other hand, weakly dependent on the solvent and temperature. The observed large anisotropy ratio (∼9) of the spinning to the tumbling modes represents the anisotropy of the solvation shell and is explained by neither the free rotor model nor the hydrodynamic continuum model. The tumbling motion is more strongly hindered than the spinning motion due to the dipolar interaction between the solute and solvent.
Спектры отражения и фотоотражения структур с квантовыми ямами на основе ZnO (2020)

Исследованы спектры отражения и модуляционного фотоотражения от эпитаксиальных слоев ZnO и Zn 1-x Mg x O, а также квантовых ям ZnO/Zn 1-x Mg x O при нормальном и наклонном падении света. Сравнение экспериментально измеренных и расчетных спектров позволило уточнить некоторые параметры экситонов в этих структурах и уточнить порядок следования энергетических зон в ZnO. Ключевые слова: гетероструктуры, квантовые ямы, экситоны, спектроскопия.
Effects of Annealing in Cd or S Vapor on Photoelectric Properties of CdS Single Crystals (1976)

Single crystals of CdS were grown from the melt under high Ar pressures and annealed in Cd or S vapor. The annealing in Cd vapor caused emission at 501 nm, 509 nm and 600 nm. The emission at 501 nm is due to the transition between the valence band and a donor (probably S vacancy or interstitial Cd) with the binding energy of 0.106 eV. The emission at 600 nm is due to the transition between the valence band and a donor with the binding energy of about 0.5 eV. The annealing in S vapor caused I1-line and emission at 730 nm, 830 nm and 1020 nm. The emission at 730 nm is a self-activated emission. It is not clear yet that the emission at 830 nm is due to Cu impurity or native defects. The luminescence center of the emission at 1020 nm is identical to the sensitizing center for photoconduction and probably composed of a native defect such as a Cd vacancy.
Supplementary Figure 6 from HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells (2023)

&lt;p&gt;PDF file - 497KB, HuR regulates WEE1 expression.&lt;/p&gt;