gebhart/patrepeval huggingface dataset:
Production of Porous Carbon from Ion Exchange Resin Waste (1999)

The possibility to produce porous carbons with controlled micropores from waste ion exchange resins wasexamined. Two waste ion exchange resins were used as starting materials: one was used for desalination of water (Waste-P) and the other was used for refining suger (Waste-Gel). They were carbonized at 500 to 900°C were nonporousdue to thermal shrinkage. Waste-Gel contained about 7wt% of calcium, and Waste-P adsorbed organics. Then, to clarifythe effect of the impurities contained in the waste resins on the pore development, the virgin resins exchanged by calcium ion and those adsorbing phenol or fructose were prepared and carbonized. Calcium ion was found to greatly affect thecarbonization behavior of the resin, and consequently prevented the resin from shrinking thermally. On the other hand, the organics adsorbed enhanced thermoplastic property of the resin. When carbonized at 900°C, the Ca exchanged resinhad almost same pore volume distribution as the carbonized Waste-Gel had. This clarified that the pore developmentof the carbonized Waste-Gel is controlled by the calcium in the resin. The porous carbons produced from the waste resins had molecular sieving property to separate carbon dioxide from methane.
Replantation of permanent incisors in children using Emdogain® (2005)

The aim of this study was to determine whether application of an enamel matrix protein derivative, Emdogain (Biora AB Malmo, Sweden) to the root surface of avulsed permanent incisors would improve postreplantation outcomes in a pediatric population. Between June 1999 and May 2002, 25 avulsed permanent maxillary incisors (22 centrals and three laterals) were treated with Emdogain and followed for up to 32 months, mean duration 20.6 months (range: 6.9-32.5 months). Mean patient age at the time of treatment was 12.0 years (range: 7.7-17.6 years) and mean extra-alveolar duration was 185 min (range: 100-300 min). At the end of their follow-up each of the replanted incisors demonstrated radiographic evidence of replacement root resorption and clinical evidence of ankylosis. None of the replanted teeth were affected by inflammatory root resorption and there was no evidence of infection. When compared with the control samples from Barrett and Kenny (Endod Dent Traumatol 1997;15:269-72.) and Andersson et al. (Endod Dent Traumatol 1989;5:38-47.) this sample treated with the Emdogain protocol demonstrated significantly less root resorption than either of the control samples (anova, P < 0.0001). Although the Emdogain protocol did not produce periodontal regeneration, it did eliminate inflammatory resorption and infection and led to significantly less root resorption compared with the two historical controls.
Supplementary Table S1 from Harnessing the Fcμ Receptor for Potent and Selective Cytotoxic Therapy of Chronic Lymphocytic Leukemia (2023)

&lt;p&gt;This table describes treatment naive patients characteristics.&lt;/p&gt;
Enantioselective Dearomative Alkynylation of Chromanones: Opportunities and Obstacles (2022)

A catalytic and highly enantioselective dearomative alkynylation of chromanones has been discovered that enables the construction of biologically relevant tertiary ether stereogenic centers. This methodology is robust, accommodating a variety of alkynes and chromanones. More than 40 substrates tested gave rise to >90% ee. Computational studies have indicated that the optimal indanyl ligand identified for most cases likely affords a network of supportive, non-covalent interactions that drive the enantioselective nature of the reaction.
Pegloticase treatment of chronic refractory gout: Update on efficacy and safety (2020)

Gout is currently the most frequent cause of inflammatory arthritis worldwide. It results from elevated serum urate and subsequent deposition of monosodium urate crystals in joints and other tissues. While many patients with gout can be managed with conventional agents (e.g., allopurinol, febuxostat), those with chronic refractory gout often fail to achieve treatment goals with these agents. Pegloticase is a recombinant, pegylated mammalian uricase developed for treatment of chronic refractory gout. Pegloticase is different than other urate lowering therapies in that it enzymatically degrades urate. Pegloticase has been evaluated in multiple studies, most importantly in two randomized controlled trials and a follow-up open-label extension. Extensive analysis of results from these studies has shown that pegloticase profoundly lowers serum urate, resolves tophi, reduces tender and swollen joint counts, decreases pain, and improves both patients' global assessments and quality of life. Pegloticase also significantly decreases blood pressure in patients with chronic refractory gout, but has no significant effect on renal function. Post hoc analyses of clinical results also indicated that chronic refractory gout patients not achieving sustained urate lowering still have significant clinical benefits with pegloticase treatment. The major limitation of pegloticase is immunogenicity and the emergence of anti-drug antibodies that result in increased drug clearance, loss of efficacy, and infusion reactions. However, these reactions can be avoided by stopping pegloticase when there is a loss of serum urate lowering. New dosing regimens and co-administration of immunosuppressive agents are also being employed to overcome this limitation and extend the benefits of pegloticase to a larger number of patients.
Web-Based Screening for Diabetic Retinopathy in a Primary Care Population: The EyeCheck Project (2005)

The objective of this study was to evaluate the feasibility of ATA category 2 Web-based screening for diabetic retinopathy in a primary care population in the Netherlands. A total of 1,676 patients in a primary care setting, with diabetes, without known diabetic retinopathy, and without previous screening by an ophthalmologist, were included between January 1 and December 31, 2003. Patients underwent a brief questionnaire and two field retinal photography. Photographs were independently read by two ophthalmologists. Outcome measures were gradability of the photographs, need for pharmacologic pupil dilation, assessment as suspect for presence of diabetic retinopathy, of neovascularization and of diabetic retinopathy, and agreement between graders. Of the population studied, 11.3% of patients required pupil dilation, average transmission time of images was 73 sec, 12.0% of patients had ungradable photographs, 10.4% of the patients with gradable photographs were assessed as "suspect for diabetic retinopathy," and 2.0% were assessed to need urgent referral. Red lesions were present in 3.5% and bright lesions were present in 1.6% of all gradable patients. Neovascularization of the disk was found in one patient. Type 1 patients had much higher rates of "suspect for diabetic retinopathy" (34.5%) than type 2 patients (9.4%). Interrater agreement kappa was 0.93. Web-based screening, using open source technology and uncompressed images, is feasible in a primary care setting, with a high rate of inter-rater agreement. Dilate-as-needed may be a sensible approach for retinal photography. The high incidence of "suspect for diabetic retinopathy" in type 1 diabetes patients illustrates that web-based diabetic retinopathy screening programs for these patients may detect diabetic retinopathy that would otherwise have gone undetected.
Ein pflegegeleitetes Sekundärpräventionsprogramm für Menschen nach einem akuten Koronarsyndrom aus Sicht von Gesundheitsexpertinnen und -experten in Österreich – eine qualitative Studie (2022)

Zusammenfassung Hintergrund Menschen nach akutem Koronarsyndrom weisen weiterhin ein hohes kardiovaskuläres Risiko auf. Eine pflegerische Intervention zur Verbesserung der Adhärenz von Betroffenen hinsichtlich der empfohlenen Präventionsmaßnahmen ist erforderlich. In deren Entwicklung sollen alle an der Versorgung beteiligten Personengruppen miteinbezogen werden, u. a. Gesundheitsexpertinnen und -experten. Ziel Ziel war es, die Ausrichtung eines dem österreichischen Kontext angepassten pflegegeleiteten Sekundärpräventionsprogramms für Menschen nach akutem Koronarsyndrom aus Sicht von Gesundheitsexpertinnen und -experten zu generieren. Methodik Die Entwicklung dieses Programms stützt sich methodisch auf das „intervention mapping“. Um die Inhalte der ersten 3 Schritte des Intervention mapping zu erarbeiten, wurden 2 Fokusgruppeninterviews und 13 Einzelinterviews mit 27 Gesundheitsexpertinnen und -experten durchgeführt. Die Datenanalyse erfolgte anhand der thematischen Analyse nach Braun und Clarke. Ergebnisse Die Ausrichtung des Programms bezieht sich auf die Bereiche „personenzentrierter Ansatz“, „Akutkrankenhaus als Initialpunkt“ und „persönliches Gespräch als zentrale Vermittlungsform“. Die erforderlichen strukturellen und personellen Rahmenbedingungen umfassen „Prioritätensetzung für die Patientenedukation im Akutkrankenhaus“, „Einrichtung einer Anlaufstelle“, „interdisziplinäre Zusammenarbeit“ und „gesetzliche Bestimmungen für die Patienteninformation“ sowie die Schaffung der Position einer „cardiac rehabilitation nurse“, welche speziell ausgebildetes Pflegepersonal übernehmen könnte. Ein vertieftes Krankheitsverständnis und ein reduzierter Angstzustand sollen die angestrebten Ergebnisse des Programms sein. Schlussfolgerung Das zu entwickelnde Programm kann dazu dienen, die nichtmedikamentöse Sekundärprävention bei den Betroffenen im Akutkrankenhaus zu initiieren und nach der Entlassung fortzuführen. Als Rahmenbedingungen müssen eine Anlaufstelle und die Funktion einer Cardiac rehabilitation nurse geschaffen werden. Somit kann diese spezialisierte Pflegeperson die Betroffenen in der Übergangsphase begleiten, während sie die Patientenedukation unter dem personenzentrierten Ansatz durchführt.
Protection of dogs against canine distemper by vaccination with a canarypox virus recombinant expressing canine distemper virus fusion and hemagglutinin glycoproteins (1997)

The canarypox virus-CDV combination vaccine, administered SC or IM, is a safe product that elicits CDV seroconversion, does not interfere with other vaccine components, and protects vaccinated pups against virulent CDV challenge exposure.
Development Of A Time-Resolved Microfluorimeter With A Synchroscan Streak Camera And Its Application To Studies Of Cell Membranes (1988)

A time-resolved microfluorimeter with a synchroscan streak camera, which can be extended to a fluorescence lifetime imaging microscope (FLIM), has been developed for the use in biomedical research and clinical diagnosis. The schematic diagram of the instrument is given in Figure 1. The key idea for this instrument is to acquire molecular information on the structure of interest observed under the fluorescence microscope by using time-resolved fluorescence spectroscopy. The fluorescence lifetime is probably the only physical observable, the absolute value of which can be reliably determined in fluorescence microscopy.
Sulfonimidamides in Medicinal and Agricultural Chemistry (2016)

The synthesis and evaluation of structural analogues and isosteres are of central importance in medicinal and agricultural chemistry. The sulfonamide functional group represents one of the most important amide isosteres in contemporary drug design, and about 500 such compounds have overcome both the pharmacological and regulatory hurdles that precede studies in humans. The mono aza analogues of sulfonamides, that is, sulfonimidamides, are rapidly gaining popularity as a novel functional group among synthetic chemists involved in the design of biologically active compounds for both pharmaceutical and agrochemical applications. Herein, we review these recent developments to showcase the promise of this functional group.
Investigations of the quantum photovoltaic effect in InAs-GaSb semiconductor superlattices (1988)

We report the observation in InAs-GaSb semiconductor superlattices of a photovoltaic effect that has a quantum origin, as it arises from the spatial separation of the electron and hole ground-state wave functions in these type II superlattices. The results are consistent with the simplest theoretical predictions, except for the voltage sign, which evidences a depopulation of the surface layer.
High-Throughput Synthesis and Characterization of Bulk Ceramics from Dry Powders (2008)

A high-throughput experimental (HTE) setup using conventional powders as raw materials was developed to synthesize and characterize ceramic bulk samples avoiding the customary liquid- or vapor-phase synthesis routes. Its functionality was verified using the well-known binary material system ZrO2-Y2O3. Libraries of 0.5 mol % yttria resolution were prepared using varying boundary systems as well as a number of liquid mixing aids. Automated powder X-ray diffraction (XRD) was applied to check the monoclinic phase content retained after heat-treatment on various positions for each sample. This phase information was used for comparison with a reference library comprising conventionally prepared samples by means of a regression analysis and mean deviation of monoclinic phase percentage. Out of the eight HTE libraries, three showed a significant comparability to the reference library.
Effect of Particle Length and Sodium Hydroxide Treatment of Wheat Straw on Site and Extent of Digestion by Lambs (1984)

Two lamb trials were conducted to determine the effects of particle length (PL; 2.5 vs 10 cm) and sodium hydroxide (NaOH) treatment (0 vs 4%) of wheat straw on dry matter (DM) intake and site and extent of DM and neutral detergent fiber (NDF) digestion. Lambs in the first trial were fed ad libitum once daily. Lambs in the second trail were fed four times/d at 6-h intervals and were sacrificed after 7 d of fecal collection to determine site of digestion. For both trials, NaOH increased (P<.05) DM intake and total tract DM and NDF digestibility. Lambs fed 2.5-cm wheat straw once daily had greater (P<.05) DM intake and lower (P<.05) digestibility of DM and NDF than with the 10-cm wheat straw diets. No main effect due to PL was observed for any variable measured when lambs were fed four times daily, but NaOH treatment increased (P<.05) ruminal DM and NDF digestibility and postruminal NDF digestibility. The 10-cm, NaOH-treated straw diet had greater (P<.05) ruminal DM and NDF digestibility than its untreated counterpart. Although not significant (P>.10), lambs fed 2.5-cm, NaOH-treated straw appeared to have a greater percentage of total NDF digestion occurring postruminally than lambs fed untreated straw, suggesting an increased flow of potentially digestible fiber to the hindgut. This is supported by a shorter ruminal retention time of digesta in lambs fed the 2.5-cm, NaOH-treated straw. Ruminal volatile fatty acid concentrations were greater for NaOH-treated straw diets, which reflect the site of digestion results. Results of the present study suggest that NaOH treatment of 2.5-cm wheat straw increased rate of passage and NDF fermentation in the hindgut, while NaOH treatment of 10-cm straw had no effect on passage rate and increased NDF fermentation in the rumen.
Pathogen receptor discovery with a microfluidic human membrane protein array (2016)

The discovery of how a pathogen invades a cell requires one to determine which host cell receptors are exploited. This determination is a challenging problem because the receptor is invariably a membrane protein, which represents an Achilles heel in proteomics. We have developed a universal platform for high-throughput expression and interaction studies of membrane proteins by creating a microfluidic-based comprehensive human membrane protein array (MPA). The MPA is, to our knowledge, the first of its kind and offers a powerful alternative to conventional proteomics by enabling the simultaneous study of 2,100 membrane proteins. We characterized direct interactions of a whole nonenveloped virus (simian virus 40), as well as those of the hepatitis delta enveloped virus large form antigen, with candidate host receptors expressed on the MPA. Selected newly discovered membrane protein-pathogen interactions were validated by conventional methods, demonstrating that the MPA is an important tool for cellular receptor discovery and for understanding pathogen tropism.
Photonic Add-Drop Filter Based on Integrated (2010)

We present an integrated and pigtailed add-drop fil- ter based on photonic crystal structures. In the characterization in static regime, the insertion losses around 25 dB are successfully overcome with the device providing error-free operation for add, drop, and multicasting operation (at 10 Gbit/s) and sustaining less than 2.5 dB of power penalty. We also emulate packet switching operation at 10 Gbit/s employing the device in combination with a silicon-wired waveguided-based integrated optical delay line, sus- taining less than 2 dB power penalty. The demonstrated add-drop filter based on photonic crystal structures provides proof of the advantages of integrated structures for future all-optical photonic nodes. This compact device would be a core element of a futuristic photonic add-drop multiplexer.
User segmentation using moving edge detection for sports simulator (2013)

This paper proposes user segmentation algorithm using moving edge detection to provide customized coaching service to users in advanced sports simulator like horse riding. To give this service in the simulator, exact user segmentation is very important. If the segmenting user from its background became better, we will get a better pose recognition results. In this paper, some of the well-known object segmentation methods to be applied to sports simulator have been investigated. Also, a moving object detection algorithm for recognizing user's poses which is a novel innovation to assure high recognition reliability in sports simulator has been proposed.
Free-Standing Silicon Ring Resonator for Low Power Optical Bistability (2010)

We demonstrate low power optical bistability in a free-standing silicon ring resonator. The transmission exhibits hysteresis for 80 µW pump power, which is over an order of magnitude lower than similar unreleased ring resonators.
The Impact of HER2/neuExpression Level on Response to the E75 Vaccine: From U.S. Military Cancer Institute Clinical Trials Group Study I-01 and I-02 (2009)

Most patients with various levels of HER2/neu expression responded immunologically and seemed to benefit from vaccination. The low expressors, specifically IHC 1(+) patients, had more robust immunologic responses and may derive the greatest clinical benefit from the E75 vaccine.
Initial results from the off‐label use of the SAPIEN S3 valve for percutaneous transcatheter pulmonary valve replacement: A multi‐institutional experience (2018)

TPVR in patients with large diameter dysfunctional RVOTs can be effectively performed with the Sapien S3. All procedures were technically successful with no embolizations, no perivalvular leaks, and excellent short-term valve function. Tricuspid valve injury from implantation of an uncovered valve was a serious procedural complication.
Therapeutic efficacy of fixed dose artesunate-mefloquine for the treatment of acute, uncomplicated Plasmodium falciparum malaria in Kampong Speu, Cambodia (2013)

This TES demonstrated reasonable efficacy in an area of possible reduced artemisinin sensitivity and high MQ IC₅₀s. Efficacy testing of FDC ASMQ should continue in Cambodia and be considered for reintroduction if efficacy returns.
Sensitivity Analysis of the Impedance Characteristics of Proton Exchange Membrane Fuel Cells (2016)

Abstract The sensitivity of the impedance characteristics to the operating conditions of the proton exchange membrane fuel cell is studied. The impedance of a cell is measured in different potentials (current densities), operating temperatures, and anode and cathode relative humidities to estimate the indifference interval of each of these parameters. The indifference interval of a parameter, defined for a specific point, refers to a range out of which the impedance results are statistically dissimilar from that specific point. The analysis presented evaluates the average indifference intervals of the potential, temperature and relative humidities to be 10 mV, 5 °C and 7%, respectively. In other words, the changes less than the above mentioned limits do not affect the impedance of the cell statistically.
<title>Photodynamic therapy of recurrent cancer of oral cavity: an alternative to conventional treatment</title> (1996)

Photodynamic therapy (PDT) with use of two Russian photosensitizers -- Photohem (hematoporphyrine derivative) in the dosage 1.5 - 5.0 mg/kg of body weight and Photosense (sulfonated aluminum phthalocyanine) in the dosage 0.5 - 1.5 mg/kg of body weight has been provided in 26 patients with spread recurrent tumors of oral cavity (tongue, oral mucose, uvula, lower lip). During PDT power density has been from 50 to 1000 mW/cm<SUP>2</SUP>, light irradiation doses ranging from 50 to 600 J/cm<SUP>2</SUP>. Therapeutic effect in term from 2 months to 3 years took place in 24 patients (92.4%). In 16 cases (61.5%) complete resorption of tumor was achieved, in 8 cases (30.9%) -- partial pesorption. No effect was found in 2 cases (7.6%). Our experience supposes that PD appears to be a reasonable alternative to the traditional therapy of recurrent tumors of oral cavity.
Information theoretic clustering of sparse cooccurrence data (2004)

A novel approach to clustering cooccurrence data poses it as an optimization problem in information theory which minimizes the resulting loss in mutual information. A divisive clustering algorithm that monotonically reduces this loss function was recently proposed. We show that sparse high-dimensional data presents special challenges which can result in the algorithm getting stuck at poor local minima. We propose two solutions to this problem: (a) a "prior" to overcome infinite relative entropy values as in the supervised Naive Bayes algorithm, and (b) local search to escape local minima. Finally, we combine these solutions to get a robust algorithm that is computationally efficient. We present experimental results to show that the proposed method is effective in clustering document collections and outperform previous information-theoretic clustering approaches.
Hematopoietic Cancer Cell Lines Can Support Replication of Sabin Poliovirus Type 1 (2015)

Viral vaccines can be produced in adherent or in suspension cells. The objective of this work was to screen human suspension cell lines for the capacity to support viral replication. As the first step, it was investigated whether poliovirus can replicate in such cell lines. Sabin poliovirus type 1 was serially passaged on five human cell lines, HL60, K562, KG1, THP-1, and U937. Sabin type 1 was capable of efficiently replicating in three cell lines (K562, KG1, and U937), yielding high viral titers after replication. Expression of CD155, the poliovirus receptor, did not explain susceptibility to replication, since all cell lines expressed CD155. Furthermore, we showed that passaged virus replicated more efficiently than parental virus in KG1 cells, yielding higher virus titers in the supernatant early after infection. Infection of cell lines at an MOI of 0.01 resulted in high viral titers in the supernatant at day 4. Infection of K562 with passaged Sabin type 1 in a bioreactor system yielded high viral titers in the supernatant. Altogether, these data suggest that K562, KG1, and U937 cell lines are useful for propagation of poliovirus.