gebhart/patrepeval huggingface dataset:
Medial-lateral Center Of Pressure Velocity Is Greater In Those With A Concussion History (2011)

Concussion is known to have a negative impact on neurocognitive functioning and motor control immediately following injury. Emerging evidence suggests persistent deficits to neurocognitive functioning may extend well beyond the acute stage of injury, but less is known about how motor control may be affected beyond the acute stage of injury. PURPOSE:To evaluate changes in gait in those with and without a concussion history. METHODS:Fifty-seven college aged participants were divided into groups based on previous concussion diagnosis [Concussed (n=28): 21.0+2.6yrs, 173.6+9.4cm, 78.1+12.1kg, 1.5+.5 concussions, 6.3+4.1 yrs prior, Control (n=29): 20.9+1.0yrs, 171.1+9.1cm, 73.1+16.8kg). All participants completed four walking evaluations under single (ie Walk and Obstacle) and dual-task (ie Walk-Cognitive and Obstacle-Cognitive) conditions. Gait parameters were recorded using the GaitRite Walkway and the Brook's Mental Task was implemented in the Cognitive conditions. The gait variables of interest were center of pressure (COP) mean velocity, maximum velocity, and range along the mediolateral axis. Differences between group performance was evaluated with multiple two-way (group x condition) ANOVAs with repeated measures. RESULTS:ANOVA tests revealed non-significant differences in COP mean velocity and range between groups (p's>0.05). Maximum velocity (cm/s) however, differed significantly between non-concussed and concussed groups for the Obstacle (624.0+169.6 vs 739.6+152.8, p=.008) and Walk-Cognitive (719.2+118.0 vs 828.3+119.6, p=.014) conditions. No differences were seen between groups on cognitive performance in either condition (p's>0.05). CONCLUSIONS:These data suggest that young adults with a concussion history have greater medial-lateral COP velocity than their matched counterparts. Overall, the observations suggest that similar to neurocogntive function there are persistent subtle changes in motor control following concussions.
Fetal and maternal morbidity in pregnant patients with Lupus: a 10-year US nationwide analysis (2023)

Our study demonstrates that fetal morbidity and severe maternal morbidity occur at a higher rate in patients with SLE compared with those without. This quantitative work can help inform and counsel patients with SLE during pregnancy and planning.
Efficient microwave-assisted synthetic protocols and in silico behaviour prediction of per-substituted β-cyclodextrins (2013)

Selective per-substituted cyclodextrin design enables the carrier's physicochemical and binding properties to be tailored and can even modify some biological native structure effects. We herein report a number of highly efficient microwave-assisted synthetic protocols for the preparation of several amino, ureido and thioureido per-substituted β-cyclodextrin derivatives. A rapid parallel synthetic approach has given a set of 14 different CD derivatives. Our strategy is supported by computational analyses which were used to estimate the physicochemical behaviour of per-substituted derivatives and to tailor suitable substituents.
Ultrafast Intersystem Crossing and Structural Dynamics of [Pt(ppy)(μ-tBu2pz)]2 (2020)

Intersystem crossing (ISC) rates of transition-metal complexes are determined by the complex interplay of a molecule's electronic and structural dynamics. To broaden our understanding of these key factors, we investigate the case of the prototypical d<sup>8</sup>-d<sup>8</sup> dimetal complex [Pt(ppy)(μ-<sup><i>t</i></sup>Bu<sub>2</sub>pz)]<sub>2</sub> using broad-band transient absorption anisotropy in combination with ultrafast fluorescence up-conversion and ab initio calculations. We find that, upon excitation of the molecule's metal-metal-to-ligand charge-transfer transition, ISC occurs in hundreds of femtoseconds from the lowest excited singlet state S<sub>1</sub> to the triplet state T<sub>2</sub>, from where the energy relaxes to the lowest energy triplet state T<sub>1</sub>. ISC to the T<sub>2</sub> state, rather than T<sub>1</sub>, is further rationalized through supporting arguments. Observed vibrational coherences along the Pt-Pt mode are attributed to the formation of nuclear wavepackets on the ground and excited electronic states that dephase prior to ISC because of the structural flexibility of the complex. Beyond demonstrating the relationship between the energy relaxation and structural dynamics of [Pt(ppy)(μ-<sup><i>t</i></sup>Bu<sub>2</sub>pz)]<sub>2</sub>, our results provide new insights into the photoinduced dynamics of d<sup>8</sup>-d<sup>8</sup> dimetal complexes more generally.
Adaptive-integration-time image sensor with real-time reconstruction function (2003)

A computational image sensor is proposed in which the pixel controls its integration time to light intensity. The integration time of each pixel is selected from among several lengths of integration time and the integration time is shortened if the pixel intensity becomes saturated. Although the integration time of each pixel varies, the pixel intensity is adjusted on the sensor in real time. The dynamic range of the pixel value output from the proposed sensor is greatly widened. A prototype of 64/spl times/48 pixels has been fabricated by using 2-poly 2-metal 0.8-/spl mu/m CMOS process. The proposed sensor has simple functions for the comparison of intermediate integration value and threshold to control the integration time and nonlinear image reconstruction. Because the maximum number of the comparison-reset operations during a frame is three, one of the four integration times can be selected pixel by pixel. The circuit and layout design of the prototype which has computational elements based on column parallel architecture are described and the fundamental functions have been verified. By the experiments, it has been verified that the sensor can achieve a wide dynamic range by adapting to light.
Implementing the VMC Specification to Reduce Ambiguity in Genomic Variant Representation. (2019)

Current methods used for representing biological sequence variants allow flexibility, which has created redundancy within variant archives and discordance among variant representation tools. While research methodologies have been able to adapt to this ambiguity, strict clinical standards make it difficult to use this data in what would otherwise be useful clinical interventions. We implemented a specification developed by the GA4GH Variant Modeling Collaboration (VMC), which details a new approach to unambiguous representation of variants at the allelic level, as a haplotype, or as a genotype. Our implementation, called the VMC Test Suite (http://vcfclin.org), offers web tools to generate and insert VMC identifiers into a VCF file and to generate a VMC bundle JSON representation of a VCF file or HGVS expression. A command line tool with similar functionality is also introduced. These tools facilitate use of this standard-an important step toward reliable querying of variants and their associated annotations.
ParsVNN: parsimony visible neural networks for uncovering cancer-specific and drug-sensitive genes and pathways (2021)

Prediction of cancer-specific drug responses as well as identification of the corresponding drug-sensitive genes and pathways remains a major biological and clinical challenge. Deep learning models hold immense promise for better drug response predictions, but most of them cannot provide biological and clinical interpretability. Visible neural network (VNN) models have emerged to solve the problem by giving neurons biological meanings and directly casting biological networks into the models. However, the biological networks used in VNNs are often redundant and contain components that are irrelevant to the downstream predictions. Therefore, the VNNs using these redundant biological networks are overparameterized, which significantly limits VNNs' predictive and explanatory power. To overcome the problem, we treat the edges and nodes in biological networks used in VNNs as features and develop a sparse learning framework ParsVNN to learn parsimony VNNs with only edges and nodes that contribute the most to the prediction task. We applied ParsVNN to build cancer-specific VNN models to predict drug response for five different cancer types. We demonstrated that the parsimony VNNs built by ParsVNN are superior to other state-of-the-art methods in terms of prediction performance and identification of cancer driver genes. Furthermore, we found that the pathways selected by ParsVNN have great potential to predict clinical outcomes as well as recommend synergistic drug combinations.
Autocalibration of an electronic compass in an outdoor augmented reality system (2002)

Accurate registration in an augmented reality system requires accurate trackers. An electronic compass can be a valuable sensor in an outdoor augmented reality system because it provides absolute heading estimates. However, compasses are vulnerable to distortion caused by environmental disturbances to Earth's magnetic field. These disturbances vary with geographic location and are not trivial to model. Static calibration methods exist but these require an explicit initial calibration step and do not adapt to changing distortion patterns. This paper describes in detail an autocalibration method that compensates for changing compass distortions. With minimal user input, it automatically measures and adjusts the calibration table used to correct the compass output. Autocalibration uses redundant heading information computed from rate gyroscopes. We demonstrate that autocalibration converges to solutions similar to a distortion table that was manually measured with a mechanical turntable. With autocalibration, an electronic compass can provide useful measurements even as the user walks around through areas of varying magnetic distortion.
Clinical Features of Celiac Disease: A Prospective Birth Cohort (2015)

A majority of children detected with persistent tTGA in screenings are asymptomatic and have normal growth by age 4 years. tTGA levels correlate more strongly with severity of mucosal lesions in symptomatic as compared with asymptomatic children.
Persistent Metal Bis(Hexafluoroacetylacetonato) Complexes Featuring a 2,2′-Bipyridine Substituted Triarylamminium Radical Cation (2010)

Herein, we describe the preparation of a 2,2'-bipyridine derivative containing a redox-active N,N'-(4,4'-dimethoxydiphenylamino) substituent (1), which readily coordinates M(hfac)(2) salts [M = Mn (2), Ni (3), Cu (4)] to generate stable, neutral, and pseudo-octahedral coordination complexes, which have been fully characterized. Cyclic voltammetry and spectroelectrochemical measurements on complexes 2-4 indicate stable one-electron oxidation processes, and the formation of persistent radical cation complexes. The neutral complexes (M = Mn or Ni) were subject to one-electron oxidation with NOPF(6) in acetonitrile, and magnetic moments of the resulting solutions were obtained using the Evans method at different temperatures. Our experimental results suggest that the first reported ferromagnetically coupled metal-triarylamminum radical cation complex is obtained when M = Mn(2+), and antiferromagnetic coupling results when M = Ni(2+). These results are supported by results from density functional theory calculations, which indicate that a π spin polarization mechanism for magnetic exchange coupling is operative in singly oxidized complexes, 2-4.
Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19 (2020)

Host excessive inflammatory immune response to SARS-CoV-2 infection is thought to underpin the pathogenesis of COVID-19 associated severe pneumonitis and acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Once an immunological complication like cytokine storm occurs, anti-viral based monotherapy alone is not enough. Additional anti-inflammatory treatment is recommended. It must be noted that anti-inflammatory drugs such as JAK inhibitors, IL-6 inhibitors, TNF-α inhibitors, colchicine, etc., have been either suggested or are under trials for managing cytokine storm in COVID-19 infections. Natural astaxanthin (ASX) has a clinically proven safety profile and has antioxidant, anti-inflammatory, and immunomodulatory properties. There is evidence from preclinical studies that supports its preventive actions against ALI/ARDS. Moreover, ASX has a potent PPARs activity. Therefore, it is plausible to speculate that ASX could be considered as a potential adjunctive supplement. Here, we summarize the mounting evidence where ASX is shown to exert protective effect by regulating the expression of pro-inflammatory factors IL-1β, IL-6, IL-8 and TNF-α. We present reports where ASX is shown to prevent against oxidative damage and attenuate exacerbation of the inflammatory responses by regulating signaling pathways like NF-ĸB, NLRP3 and JAK/STAT. These evidences provide a rationale for considering natural astaxanthin as a therapeutic agent against inflammatory cytokine storm and associated risks in COVID-19 infection and this suggestion requires further validation with clinical studies.
Enhancement Of Features In Epicardial Activation Maps Using Spatial Derivatives (2005)

This paper discusses the use of spatial derivative maps to increase the resolution of areas of delayed or blocked conduction seen in contour maps of epicardial activation. Data from an experimental model of infarction was used. Spatial derivatives are obtained by filtering isochronous epicardial maps and contouring the resulting rates of change of conduction.
Population Data of ABO Gene Applicable to Human Identification in Koreans (2003)

Abstract Genomic DNA was isolated from buccal swabs by the QIAamp DNA Mini Kit (QIAGEN). The primers used for amplification and sequencing of exon 6 and 7 of ABO gene were suggested by Lee and Chang (1), and Ogasawara et al. (2), respectively. About 1-2 ng of genomic DNA was used for PCR in 25 μL reaction volume. PCR mixture contained 10 mM Tris-HCl pH 8.5, 50 mM KCl, 1.5 mM MgCl2, 200 μM of each dNTP, 0.25 μM of each primer, and 1 U of AmpliTaq Gold DNA Polymerase (Applied Biosystems). Thermal cycling was performed initially at 95°C for 10 min, then 35 cycles consisting of 95°C for 1 min, 60°C for 1 min for exon 6 and 63°C for 1 min for exon 7, 72°C for 1 min, followed by 10 min extension at 72°C in a GeneAmp PCR System 9600 (Perkin Elmer).
Hepatitis B and C Virus Serologies among Japanese Americans with Hepatocellular Carcinoma (1996)

A cohort of 5924 Japanese American men was examined between 1967 and 1970 for hepatocellular carcinoma (HCC). By 1992, 24 incident cases of HCC were histologically confirmed in the group. Frozen serum samples from the 24 men with HCC and 72 age-matched controls were tested for hepatitis B surface antigen (HBsAg), antibodies to hepatitis B core antigen, antibodies to HBsAg, and antibodies to hepatitis C virus. HBsAg was detected in 15 (62.5%) of 24 HCC cases compared with 2 (2.8%) of 72 controls (odds ratio, 43.0; 95% confidence interval, 5.7-325.5). None of the cases and only 1 control had antibody to hepatitis C virus. This study demonstrates a strong association between hepatocellular carcinoma and hepatitis B virus infection, but not with hepatitis C virus infection, among men of Japanese ancestry in Hawaii.
Society of Critical Care Medicine Critical Care Self-Assessment Program III (1983)

Critical Care Medicine encompasses an extremely broad scope. Examination questions were, therefore, chosen to cover a wide variety of critical care topics. A near Gaussian distribution of scores was found for all physician groups studied. We believe the low mean score of 15% reflects the general difficulty of the examination as well as the tendency of many critical care practitioners to master knowledge poorly outside his or her primary specialty. Hopefully, this examination with rationales and references will expose the practitioner to topics and literature with which he or she has not been previously familiar. Only by integrating knowledge from each of the primary specialities can the practitioner provide optimal care for the critically ill. It is our hope that this examination represents a positive learning experience for its past and future participants. If we have stimulated thought, discussion, and further study in the area of critical care medicine, then our efforts in the preparation of this program have been worthwhile.
Phytoestrogen content of foods—a compendium of literature values (1996)

Plant compounds with estrogenic activity may play a role in cancer prevention, moderation of menopausal symptoms, and other health effects. To facilitate research on these possible actions, the literature was reviewed for quantitative data on the levels of known phytoestrogens (daidzein, genistein, coumestrol, formononetin, and biochanin A) in food plants. For comparative purposes, all phytoestrogen levels were recalculated on a wet weight basis. Details on analytic procedures are given as well. High-performance liquid chromatography was the method most often used to analyze these compounds in foods. Most significant sources of isoflavone and coumestan phytoestrogens include soybeans, soy flour, soy flakes, isolated soy protein, traditional soy foods such as tofu and soy drinks, second-generation say foods, sprouts, and other legumes. Finally, medians among reported values of phytoestrogen content are provided for some of the most commonly eaten foods with quantitative data available. These may be used to calculate dietary intake of daidzein, genistein, coumestrol, formononetin, and biochanin A.
DESCRIPTION OF A HIGH TEMPERATURE DOWNHOLE FLUID SAMPLER (1986)

Downhole fluid samplers have been used for years with limited success in high temperature geothermal wells. This paper discusses the development and operating principles of a high temperature downhole fluid sampler, reliable at obtaining samples at temperatures of up to 350/sup 0/C. The sampler was used successfully for recovering a brine sample from a depth of 10,200 ft in the Salton Sea Scientific Drilling Project well.
Donor Registries and Search Strategies (2012)

The optimal donor of hematopoietic progenitor cells shares alleles of the major histocompatibility genes with the recipient. This chapter describes the strategies aimed at identifying such a matched donor from registries of volunteers or from umbilical cord blood banks.
In vitroeffect of CTAB- and PEG-coated gold nanorods on the induction of eryptosis/erythroptosis in human erythrocytes (2011)

Gold nanorods (Au-NRs) have attracted enormous interest due to their size and unique optical properties. Many studies have demonstrated their use in biomedical systems. However, their potential toxicity is not fully understood. This study evaluated the effects of the Au-NRs (15 nM × 64 nM) coated with CTAB (cetyltrimethylammonium bromide) or PEG (polyethylene glycol) in human erythrocytes on the induction of haemolysis and erythroptosis. In our study, erythroptosis (also known as eryptosis) was determined systematically through the measurement of feature events of apoptosis by flow cytometry. We found that the CTAB- and PEG-coated Au-NRs up to 0.5 nM did not cause severe haemolysis. However, the CTAB-Au-NRs were more toxic than the PEG-Au-NRs. The toxicity of the CTAB-Au-NRs was largely due to the CTAB residues from desorption or incomplete purification. Mechanistically, cytosolic Ca(2+) ions seem to be the key mediator in the eryptosis/erythroptosis mediated by the CTAB or CTAB-Au-NRs while caspase-3 and reactive oxygen species did not contribute much to the process.
Identifying Cultural Markers for Web Application Design Targeted to a Multi-cultural Audience (2008)

This paper addresses the problem of defining a Web design process suitable for the multi-cultural audience of a Web application in the globalization era. Traditional usability guidelines implicitly depend on the background of the audience, and may overlook specific preferences dictated by the cultural context. To overcome this limit, the notion of culturability has been proposed, which extends traditional usability to take into account usage preferences stemming from multiple cultural conventions. The paper builds upon a case study (the comparison of Chinese and Western e-commerce Web sites) and proposes a working definition of culturability, based on cultural markers; moreover, an effective methodology for identifying cultural markers and turning them into design guidelines is established and validated by letting groups of users with different cultures evaluate exemplary Web applications incorporating different versions of the candidate cultural markers.
Circuit Board Layout for Automotive Electronics (2007)

EMC and environmental requirements placed on automotive electronics present unique board layout challenges. This paper discusses component placement and trace routing strategies for circuit boards that will be used in automotive applications.
ABSOLUTE PROPERTIES OF THE LOW-MASS ECLIPSING BINARY CM DRACONIS (2009)

Spectroscopic and eclipsing binary systems offer the best means for determining accurate physical properties of stars, including their masses and radii. The data available for low-mass stars have yielded firm evidence that stellar structure models predict smaller radii and higher effective temperatures than observed, but the number of systems with detailed analyses is still small. In this paper we present a complete reanalysis of one of such eclipsing systems, CM Dra, composed of two dM4.5 stars. New and existing light curves as well as a radial velocity curve are modeled to measure the physical properties of both components. The masses and radii determined for the components of CM Dra are M1=0.2310+/-0.0009 Msun, M2=0.2141+/-0.0010 Msun, R1=0.2534+/-0.0019 Rsun, and R2=0.2396+/-0.0015 Rsun. With relative uncertainties well below the 1% level, these values constitute the most accurate properties to date for fully convective stars. This makes CM Dra a valuable benchmark for testing theoretical models. In comparing our measurements with theory, we confirm the discrepancies reported previously for other low-mass eclipsing binaries. These discrepancies seem likely to be due to the effects of magnetic activity. We find that the orbit of this system is slightly eccentric, and we have made use of eclipse timings spanning three decades to infer the apsidal motion and other related properties.
Quantitative analysis of the active components and the by‐products of eight dry extracts of Hypericum perforatum L. (St John's wort) (2002)

The major components of eight different batches of commercially available dry extracts of Hypericum perforatum L. were quantified. Hyperforin (1), hypericin (2) and flavonoids, which are considered to play key roles in the treatment of mild and moderate depressive disorders, were determined by HPLC methods. The contents of 1, 2 and flavonoids were found to be in the range of 1.3-3.9%, 0.19-0.30%, and 4.8-11.4%, respectively. Generally extracts contained, besides the so-called active components, a wide variety of by-products which may act partially as co-effectors and affect the technological properties of the extracts. Water-soluble sugars form one of the main groups of these by-products, and a procedure for the purification and quantification of such sugars in H. perforatum using HPLC with refractive index detection has been established. Native fructose, glucose and sucrose, as well as lactose added during the processing of the extracts, were determined. The total sugar content in the dry herbal extracts varied from 19 to 25% by weight. Further, citric acid (0.9-2.3%) and malic acid (2.3-3.1%) were determined by HPLC, tannins (6.2-9.0%) and total ash (4.9-8.4%) were quantified according to the methods described in the European Pharmacopoeia, and the content of the total protein (3.9-8.3%) was estimated by elemental analysis. Thus, 60-70% of the compounds of the H. perforatum dry extracts have been quantified.