gebhart/patrepeval huggingface dataset:
Women and legal guardianship (2009)

Having established the boundaries within which women's experience of property operated, the remaining chapters of this book consider the property experience of women in relation to the family estate, how women related to the concept of the family interest and in what contexts their interests differed. This chapter considers instances, in this class, when the traditional structure of the family was suspended, such as when the heir to the estate was a minor, or insane. When the heir to a landed estate was a minor, or was declared insane, the management of her or his welfare and landed estate came within the remit of the Court of Chancery. The prevailing structure of the family, in which control over family property was exercised by the husband and father, was therefore suspended and there were increased opportunities for women to undertake an expanded role in the management of family property as guardians of minors, or as committees responsible for the affairs of the insane.
Cerebral Metabolic Adaptation and Ketone Metabolism after Brain Injury (2007)

The developing central nervous system has the capacity to metabolize ketone bodies. It was once accepted that on weaning, the 'post-weaned/adult' brain was limited solely to glucose metabolism. However, increasing evidence from conditions of inadequate glucose availability or increased energy demands has shown that the adult brain is not static in its fuel options. The objective of this review is to summarize the body of literature specifically regarding cerebral ketone metabolism at different ages, under conditions of starvation and after various pathologic conditions. The evidence presented supports the following findings: (1) there is an inverse relationship between age and the brain's capacity for ketone metabolism that continues well after weaning; (2) neuroprotective potentials of ketone administration have been shown for neurodegenerative conditions, epilepsy, hypoxia/ischemia, and traumatic brain injury; and (3) there is an age-related therapeutic potential for ketone as an alternative substrate. The concept of cerebral metabolic adaptation under various physiologic and pathologic conditions is not new, but it has taken the contribution of numerous studies over many years to break the previously accepted dogma of cerebral metabolism. Our emerging understanding of cerebral metabolism is far more complex than could have been imagined. It is clear that in addition to glucose, other substrates must be considered along with fuel interactions, metabolic challenges, and cerebral maturation.
Potential role of urinary angiotensinogen in predicting antiproteinuric effects of angiotensin receptor blocker in non-diabetic chronic kidney disease patients: a preliminary report (2012)

The antiproteinuric effects of ARB were different according to the initial urinary angiotensinogen levels. These results suggest the potential value of the initial urinary AGT/Cr for predicting the therapeutic effect of ARB in proteinuric non-diabetic CKD patients.
Gain characteristics of InGaN/GaN quantum well diode lasers (1998)

We have investigated spectroscopically the gain characteristics of InGaN quantum well (QW) diode lasers. While the transparency condition can be reached at a moderate current density, the filling of localized band-edge states is a prerequisite for achieving lasing in this profoundly nonrandom alloy.
Accuracy and Precision of Age Estimates for Pallid Sturgeon from Pectoral Fin Rays (2004)

Abstract Accurate age information is critical to the biological understanding and management of most fish species, but particularly for species of concern, such as the pallid sturgeon Scaphirhynchus albus. The accuracy and precision of pallid sturgeon age estimates from pectoral fin ray sections has never been established, yet all accumulated age information for the species was collected using this technique. To examine the accuracy and precision of age estimates, 16 pectoral fin ray samples from age-6 pallid sturgeon were obtained from Gavins Point National Fish Hatchery, South Dakota. The fin rays were sectioned, mounted, and independently examined twice by each of two readers. Only 28.1% of the age estimates accurately reflected the known age of the fish. Multiple readings of the same sample by the same reader (within-reader precision) only agreed 25% of the time, differences being as great as 5 years between the two estimates. Between-reader agreement was 46.9%, the two readers' estimates of the same fish differing by as much as 2 years. Because of low accuracy and precision, estimated ages from pallid sturgeon pectoral fin rays should be viewed with caution.
Multi-channel wireless LAN distributed antenna system based on radio-over-fiber techniques (2004)

We introduce the multi-channel WLAN system based on RoF techniques that realize efficient and flexible network operations. Single-channel optical transmission characteristics of an IEEE802.11a or 11b signal are clarified, and multi-channel transmission performances are discussed.
Mutation allele frequency threshold does not affect prognostic analysis using next-generation sequencing in oral squamous cell carcinoma (2018)

TP53, NOTCH1, CASP8, CDKN2A, and CDH1 are the most frequently mutated genes in OSCC patients. The allele frequency threshold used in this study does not affect the results of clinical outcome analysis.
<title>Enhanced process control of submicron contact definition</title> (1991)

The aggressive drive to reduce device geometries to submicron levels while utilizing ULSI design capabilities has posed many challenges to traditional semiconductor process technology. Among the most critical is the ability to maintain satisfactory contact between two levels of metal through contact holes significantly smaller than the actual design rule itself. Traditional technologies for greater than one micron design rules are not capable of maintaining the consistent output necessary to achieve and maintain Six Sigma process control. Isotropic plasma etching of doped and undoped oxides has been studied as an alternative to the " wet" isotropic etch in the traditional " wet-dry" contact hole etch process scheme. The isotropic etch was characterized using Taguchi and Response Surface Methodology (RSM) multilevel statistical experimental designs. Optimized conditions resulted in process capability of greater than 2. 0 Cpk control measured in reference to critical dimension performance and electrical data analysis.
Logical Identification of an Allantoinase Analog (puuE) Recruited from Polysaccharide Deacetylases (2008)

The hydrolytic cleavage of the hydantoin ring of allantoin, catalyzed by allantoinase, is required for the utilization of the nitrogen present in purine-derived compounds. The allantoinase gene (DAL1), however, is missing in many completely sequenced organisms able to use allantoin as a nitrogen source. Here we show that an alternative allantoinase gene (puuE) can be precisely identified by analyzing its logic relationship with three other genes of the pathway. The novel allantoinase is annotated in structure and sequence data bases as polysaccharide deacetylase for its homology with enzymes that catalyze hydrolytic reactions on chitin or peptidoglycan substrates. The recombinant PuuE protein from Pseudomonas fluorescens exhibits metal-independent allantoinase activity and stereospecificity for the S enantiomer of allantoin. The crystal structures of the protein and of protein-inhibitor complexes reveal an overall similarity with the polysaccharide deacetylase beta/alpha barrel and remarkable differences in oligomeric assembly and active site geometry. The conserved Asp-His-His metal-binding triad is replaced by Glu-His-Trp, a configuration that is distinctive of PuuE proteins within the protein family. An extra domain at the top of the barrel offers a scaffold for protein tetramerization and forms a small substrate-binding cleft by hiding the large binding groove of polysaccharide deacetylases. Substrate positioning at the active site suggests an acid/base mechanism of catalysis in which only one member of the catalytic pair of polysaccharide deacetylases has been conserved. These data provide a structural rationale for the shifting of substrate specificity that occurred during evolution.
Rate and Predictors of Spontaneous Resolution of Prenatally Diagnosed Primary Nonrefluxing Megaureter (2002)

Most cases of prenatally diagnosed, primary nonrefluxing megaureter resolve spontaneously. Grades 1 to 3 hydronephrosis tend to resolve between ages 12 and 36 months. For these grades followup intervals may be progressively elongated after a pattern of improving hydronephrosis has been established. In children with grade 4 or 5 hydronephrosis, or a retrovesical ureteral diameter of greater than 1 cm. the condition may resolve slowly and require surgery.
STEAM and Environmental Justice in an Interdisciplinary Context (2023)

This course proposes an interdisciplinary perspective, envisions unique synergies between environmental justice concepts and STEAM projects on mining, and aims to solidify a foundation based on justice, equity, equality, and empathy for STEM students and faculty. Our (S)TEAM made of professors in three academic departments underscores interdisciplinary and diversity connections through an interdisciplinary team-taught course, units on environmental justice related to mining, teaching of literary texts, and STEAM projects. We also involved faculty, alumni, and our campus and city community through STEAM exhibits.
Early Postnatal Loss of Heat Sensitivity Among Cutaneous Myelinated Nociceptors in Swiss–Webster Mice (2010)

Cutaneous myelinated nociceptors are known to exhibit considerable heterogeneity in their response to noxious heat. In the present experiments, we studied heat sensitivity among myelinated nociceptors during early postnatal life to determine whether this heterogeneity is correlated with other physiological and anatomical properties. A total of 129 cutaneous myelinated nociceptors were recorded intracellularly and characterized using mechanical and thermal skin stimuli in ex vivo preparations from neonatal Swiss-Webster (SW) mice across postnatal ages P2-P10; physiologically identified cells were iontophoretically labeled with neurobiotin for analyses of dorsal horn terminations from heat-sensitive and heat-insensitive cells. Our results show that heat sensitivity is not strictly correlated with other physiological or anatomical properties, most notably mechanical threshold or laminar termination patterns, of myelinated nociceptors at these ages. Further, we found a marked decline in the number of heat-sensitive myelinated mechanonociceptors (A-mechanoheat nociceptors [AMHs]) during this early postnatal period. Indeed, 68% of myelinated nociceptors were AMHs between P2 and P5, whereas this percentage dropped to 36% between P6 and P10. Multiple independent lines of evidence suggest that this decrease reflects a change in phenotype in a subset of myelinated nociceptors that lose sensitivity to noxious heat in early postnatal life. Interestingly, evidence was also obtained for a significant strain difference since the early transient excess in the number of AMHs in P2-P5 SW neonates was not present in similarly aged neonates from the C57Bl/6 strain. Potential mechanisms underlying these postnatal changes in AMH number are discussed.
Robotic vs. minimally invasive mitral valve repair: A 5‐year comparison of surgical outcomes (2022)

Both short-term and mid-term outcomes of robotic and nonrobotic minimally invasive mitral repair surgery are comparable.
The possible involvement of intestine-derived IgA1: a case of IgA nephropathy associated with Crohn’s disease (2016)

This case represents the possibility that the intestine-derived IgA1 can be the origin of galactose-deficient IgA which is known to cause IgA nephropathy exacerbation.
P34  Effect of a triclosan/PVM/MA copolymer/fluoride dentifrice on volatile sulfur compounds in vitro (2005)

Objective The objective of the investigation was to document the in vitro efficacy of a triclosan/PVM/MA copolymer/fluoride (TCF) dentifrice against the formation of volatile sulfur compounds (VSC) as well as the growth of H 2 S‐producing bacteria. Clinical studies using organoleptic judges, gas chromatography, or a portable sulfide monitor have generally been employed in the assessment of treatments for the control of oral malodor. However, these studies are not appropriate for screening purposes because of the expense and time required. Methods An in vitro method was developed for the purpose of screening new technologies for their ability to control VSC formation and for determining bio‐equivalence of efficacy when implementing changes in existing formulations. The method combines basic microbiological methods, dynamic flow cell techniques and head space analysis. The in vitro VSC method was validated by comparing the efficacy of two dentifrices containing TCF with a control fluoride dentifrice as the TCF products have been clinically proven to control oral malodor. Results In the validation studies, the TCF‐containing dentifrices were significantly better ( P &lt; 0.05) than the control dentifrice in inhibiting VSC formation and reducing H 2 S‐producing bacteria. For example, when compared to baseline, the TCF dentifrices reduced VSC formation between 42 and 49% compared to the control dentifrice which reduced VSC formation 3%. There was no significant difference ( P &gt; 0.05) between the two TCF dentifrices. Conclusion Using an in vitro breath VSC model, it has been demonstrated that two variants of a dentifrice containing triclosan, PVM/MA copolymer and fluoride have efficacy that is significantly better than a control fluoridated dentifrice and that there is no significant difference between the triclosan/PVM/MA copolymer/fluoride dentifrice variants.
Lysophosphatidylethanolamine and 2-desoxylysophosphatidylethanolamine derivatives. 1. Potential renin inhibitors (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLysophosphatidylethanolamine and 2-desoxylysophosphatidylethanolamine derivatives. 1. Potential renin inhibitorsFrancis R. Pfeiffer, Suzanne C. Hoke, Clara K. Miao, Ralph E. Tedeschi, Josephine Pasternak, Richard Hahn, Robert W. Erickson, Herman W. Levin, Charlotte A. Burton, and Jerry A. WeisbachCite this: J. Med. Chem. 1971, 14, 6, 493–499Publication Date (Print):June 1, 1971Publication History Published online1 May 2002Published inissue 1 June 1971https://pubs.acs.org/doi/10.1021/jm00288a008https://doi.org/10.1021/jm00288a008research-articleACS PublicationsRequest reuse permissionsArticle Views169Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Flexible Fibre Supercapacitor using Synthesized Biomass based Activated Carbon and Few Layer Graphene for Wearable Electronic Devices (2019)

We have fabricated a flexible fibre supercapacitor having twisted architecture incorporating synthesized carbonaceous electrode materials from widely available inexpensive biomass (banana peel) for energy storage which can be utilized for powering emerging wearable electronic textiles and devices. Activated carbon and few layer graphene were synthesized by carbonizing KOH impregnated and ethanol/acetone washed banana peels respectively at high temperature under inert atmosphere. The synthesized carbonaceous electrode materials along with TiO2 nanopowder were deposited on conductive carbon fibre followed by dip coating with gel electrolyte and twisting to develop the supercapacitor. The fabricated fibre supercapacitor demonstrated high specific capacitance of 15.45 F/g and volumetric capacitance of 1.77 F/cm3 at 10mV/s scan rate. The developed supercapacitor retained ~92% of capacitance upon bending. The fibre supercapacitor can be fabricated on large scale using simple methods and inexpensive biomass for powering wearable electronic applications.
Purification of a Young Age-Related Glycoprotein (Ugl-Y) from Normal Human Urine1 (1987)

Ugl-Y is a glycoprotein that is detected in normal urine samples from young men and women aged 0 to 17 years. It was purified by ammonium sulfate precipitation and various column chromatographies including affinity chromatography using anti-adult urine antibody coupled to Sepharose 4B. The homogeneity of the glycoprotein was confirmed by polyacrylamide gel electrophoresis, isoelectric focusing, column chromatography on Sephadex G-75, and the precipitation reaction with anti-Ugl-Y antibody. It was shown to have a molecular weight of 29,000 by gel filtration, and to contain 5.2% neutral sugars (mannose and galactose) and 4% hexosamine (glucosamine). Amino acid analysis of the glycoprotein indicated high contents of acidic and hydroxylic amino acids. Its origin is unknown.
3PC-036 Comparison of metabolite levels in serum and tears: implications for the dilution of autologous-serum-eye-drops (2019)

<h3>Background</h3> No general standards exist for the optimal dilution factor of autologous-serum-eye-drops (ASED) to treat dry eye syndrome (DES).<sup>1 2</sup> While dilution reduces patient burden, simplifies logistics and potentially decreases anti-proliferative effects from TGF-β, better epithelial healing with non-diluted ASED in Sjögren Syndrome, but not in non-Sjögren DES have been reported.<sup>2</sup>. <h3>Purpose</h3> The ratio of serum to tear concentration for a range of metabolites in ASED after prolonged storage time was determined to define dilution that maintains metabolite concentrations equal or above those in tears. <h3>Material and methods</h3> After autologous whole blood donation, unit dose ASED were prepared and stored at −20°C for 9 months. Concentration changes of 14 sphingolipids (SLs), 14 lysophosphatidylcholines (LPCs) and 76 phosphatidylcholines (PCs) were determined in ASED on day 0 and day 273 by LC-MS/MS using the Absolute/DQ-p180-Kit (Biocrates Life Sciences) and compared to those in tears of the same person. <h3>Results</h3> The concentrations of all SLs in ASED increased by 30%–80% within 9 months. Compared to tears, the concentrations were 10-fold (day 0) to 14-fold (day 273) higher. The concentrations of all LPCs decreased by 50%–75%, with 20 and five times higher levels on day 0 and day 273 in ASED compared to tears. Most PCs showed a less than two-fold increase, while PC ae C30:1/C38:1/C38:2 increased by five–six-fold. In sum, all PC-concentrations were about 16–19-fold higher in ASED (day 0–day 273) than in tears. <h3>Conclusion</h3> We observed an increase in SLs probably through the release of sphingosine-1-phosphate from platelets during blood clotting. The decrease in LPCs may be linked to a shift from LPCs to PCs through the presence of LPC-acyltransferases. After 9 months at −20°C, the LPC levels still exceeded those in tears by five-fold. These data support a dilution up to five-fold as suggested by others (reviewed in <sup>2</sup>). Because certain patient populations may benefit from less diluted ASED, an individual approach seems indicated until more clinical information stratified by cause and severity of DES is available. <h3>References and/or acknowledgements</h3> 1. Drew VJ, et al. <i>Front Med (Lausanne)</i>2018;5:33. 2. <i>The Royal College of Ophthalmologists guidelines on serum eye drops for the treatment of severe ocular surface disease</i>2017. No conflict of interest.
Composite Cathode for Low-Temperature All-Solid Polymer Lithium Cells (2004)

A novel composite cathode for all-solid polymer electrolyte cells has been proposed to operate at lower temperatures. The cathode consists of high conductivity polymer electrolyte, and a boroxine ring containing compound The Li/polymer electrolyte/composite cathode cell could operate at a temperature as low as 40°C and at current density of 0.1 mA/cm2, achieving cathode capacities of over 130 mAh/g for © 2004 The Electrochemical Society. All rights reserved.
Key Establishment with Source Coding and Reconciliation for Wireless Sensor Networks (2006)

This paper presents a symmetric key establishment protocol, called event-based reconciliation (ERS), that does not require sensor nodes to store pairwise keys prior to deployment. The novel idea behind ERS is to establish symmetric keys by exchanging the secret key information via distributed source coding that uses some event data as side information. Any two neighboring sensor nodes that are able to detect the same event first exchange some key information using distributed source coding and data of the event detected in the overlapping sensing region, and reconcile a symmetric key in two iterations. A key expansion algorithm is also presented to enhance the recovery of key bits in the presence of bit errors and to improve the secrecy of the key establishment. Performance evaluation results show that ERS has low memory and communication overhead compared to previous symmetric key distribution schemes
Cancer Genetics/Epigenetics and the X Chromosome: Possible New Links for Malignant Glioma Pathogenesis and Immune-Based Therapies (2000)

Human high-grade gliomas (HGGs) are rapidly progressing heterogeneous brain tumors of unknown etiology and there are no effective treatment modalities available. The recent discovery of cancer-specific antigens has opened new doors for specific tumor-targeted treatments using passive and active immunotherapeutic strategies. In particular, SEREX (serological analysis of recombinant cDNA expression libraries) has aided in the discovery of numerous new tumor antigens. These specific tumor antigens are located on chromosome X and are expressed predominantly in the testes among normal organs, and hence termed Cancer/Testis Antigens (CTAs). We found that the vast majority of HGG patients overexpress a receptor for an immune regulatory cytokine, interleukin 13 (IL-13), which differs from the normal tissue physiological receptor. Interestingly, the HGG-associated receptor protein, IL-13R alpha, is expressed solely in the testes and its gene is localized to chromosome X, which mirror the expression pattern and genomic localization of CTAs. There is little evidence for frequent gross structural abnormalities on chromosome X in HGG. Although the mechanism that causes X chromosome-linked CTAs to be aberrantly expressed in tumors is not fully understood, evidence is beginning to point toward the DNA methylation dysregulation that occurs in tumor cells as being implicit in this process and perhaps in the oncogenic process as well. Therefore, further study of the phenomenon of CTAs may bring the dual benefit of better understanding tumorigenesis and providing new molecular tools for better management of HGGs. Also, we propose that the X chromosome may in fact be an important player in HGG oncogenesis.