gebhart/patrepeval huggingface dataset:
Adaptive temporal refinement in injection molding (2018)

Mold filling is an injection molding stage of great significance, because many defects of the plastic components (e.g. weld lines, burrs or insufficient filling) can occur during this process step. Therefore, it plays an important role in determining the quality of the produced parts. Our goal is the temporal refinement in the vicinity of the evolving melt front, in the context of 4D simplex-type space-time grids [1, 2]. This novel discretization method has an inherent flexibility to employ completely unstructured meshes with varying levels of resolution both in spatial dimensions and in the time dimension, thus allowing the use of local time-stepping during the simulations. This can lead to a higher simulation precision, while preserving calculation efficiency. A 3D benchmark case, which concerns the filling of a plate-shaped geometry, is used for verifying our numerical approach [3]. The simulation results obtained with the fully unstructured space-time discretization are compared to those obtained with the standard space-time method and to Moldflow simulation results. This example also serves for providing reliable timing measurements and the efficiency aspects of the filling simulation of complex 3D molds while applying adaptive temporal refinement.
Metabolite Dysregulation by Pranlukast in Mycobacterium tuberculosis (2022)

<i>Mycobacterium tuberculosis</i> has been infecting millions of people worldwide over the years, causing tuberculosis. Drugs targeting distinct cellular mechanisms including synthesis of the cell wall, lipids, proteins, and nucleic acids in <i>Mtb</i> are currently being used for the treatment of TB. Although extensive research is being carried out at the molecular level in the infected host and pathogen, the identification of suitable drug targets and drugs remains under explored. Pranlukast, an allosteric inhibitor of <i>Mt</i>ArgJ (<i>Mtb</i> ornithine acetyltransferase) has previously been shown to inhibit the survival and virulence of <i>Mtb</i>. The main objective of this study was to identify the altered metabolic pathways and biological processes associated with the differentially expressed metabolites by PRK in <i>Mtb</i>. Here in this study, metabolomics was carried out using an LC-MS/MS-based approach. Collectively, 50 metabolites were identified to be differentially expressed with a significant <i>p</i>-value through a global metabolomic approach using a high-resolution mass spectrometer. Metabolites downstream of argJ were downregulated in the arginine biosynthetic pathway following pranlukast treatment. Predicted human protein interactors of pranlukast-treated <i>Mtb</i> metabolome were identified in association with autophagy, inflammation, DNA repair, and other immune-related processes. Further metabolites including <i>N</i>-acetylglutamate, argininosuccinate, L-arginine, succinate, ergothioneine, and L-phenylalanine were validated by multiple reaction monitoring, a targeted mass spectrometry-based metabolomic approach. This study facilitates the understanding of pranlukast-mediated metabolic changes in <i>Mtb</i> and holds the potential to identify novel therapeutic approaches using metabolic pathways in <i>Mtb</i>.
Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes (2021)

Cancer extracellular vesicles (EVs) shuttle at distance and fertilize pre-metastatic niches facilitating subsequent seeding by tumor cells. However, the link between EV secretion mechanisms and their capacity to form pre-metastatic niches remains obscure. Using mouse models, we show that GTPases of the Ral family control, through the phospholipase D1, multi-vesicular bodies homeostasis and tune the biogenesis and secretion of pro-metastatic EVs. Importantly, EVs from RalA or RalB depleted cells have limited organotropic capacities <i>in vivo</i>and are less efficient in promoting metastasis. RalA and RalB reduce the EV levels of the adhesion molecule MCAM/CD146, which favors EV-mediated metastasis by allowing EVs targeting to the lungs. Finally, RalA, RalB, and MCAM/CD146, are factors of poor prognosis in breast cancer patients. Altogether, our study identifies RalGTPases as central molecules linking the mechanisms of EVs secretion and cargo loading to their capacity to disseminate and induce pre-metastatic niches in a CD146-dependent manner.
Electron Trapping at Point Defects on Hydroxylated Silica Surfaces (2007)

The origin of electron trapping and negative charging of hydroxylated silica surfaces is predicted based on accurate quantum-mechanical calculations. The calculated electron affinities of the two dominant neutral paramagnetic defects, the nonbridging oxygen center, identical with Si-O*, and the silicon dangling bond, identical with Si*, demonstrate that both defects are deep electron traps and can form the corresponding negatively charged defects. We predict the structure and optical absorption energies of these diamagnetic defects.
Joint prestack waveform inversion and acoustic reverse time migration (2017)

We propose a workflow that combines reverse time migration and prestack waveform inversion which allows an automatic model update in an iterative manner to produce accurate depth images and elastic depth models, which in turn, can provide the estimation of the subsurface petrophysical properties. By demonstrating our workflow on the real seismic data from the Cascadia Subduction Zone, we show that our proposed method can provide an accurate depth image and subsurface elastic properties which can be applied to any geologic setting around the world. Presentation Date: Wednesday, September 27, 2017 Start Time: 4:20 PM Location: 370D Presentation Type: ORAL
Improving load balancing techniques by location awareness at indoor femtocell networks (2016)

Femtocells are the auspicious solution for the coverage and capacity challenges that mobile operators are currently facing indoors. Whereas some operators are focused on offloading data traffic from macrocells to femtocells, others prefer to ensure indoor coverage and prioritize voice traffic in order to mitigate the negative impact of blocked or dropped calls. In this context, this paper proposes a novel self-optimizing mechanism to prevent congestion problems at indoor environments, focused on operators that prioritize voice traffic connections. A challenge specific to femtocells is that they normally can only serve a small number of simultaneous connections. Based on this restriction, the proposed mechanism resizes femtocell coverage areas by tuning their transmission powers for load balancing purposes. How information on user location can enhance the optimization process is also investigated in this paper. According to this, two methods to estimate the received signal level per user are evaluated. Finally, the performance is studied by means of both simulations and a real field trial.
Single-phase Split-bolus Dual Energy Computed Tomography Angiography for Evaluation of Hemoptysis (2018)

Combined DECTA is a novel technique that enables simultaneous evaluation of both systemic and pulmonary vascular cause of hemoptysis in a single acquisition with small contrast dose. Both injection protocols "A" and "B" were equally efficacious in simultaneous opacification of both the aorta and pulmonary arteries. To the best of our knowledge, such a protocol has never been described for hemoptysis evaluation.
Acoustic droplet vaporization is initiated by superharmonic focusing (2014)

Acoustically sensitive emulsion droplets composed of a liquid perfluorocarbon have the potential to be a highly efficient system for local drug delivery, embolotherapy, or for tumor imaging. The physical mechanisms underlying the acoustic activation of these phase-change emulsions into a bubbly dispersion, termed acoustic droplet vaporization, have not been well understood. The droplets have a very high activation threshold; its frequency dependence does not comply with homogeneous nucleation theory and localized nucleation spots have been observed. Here we show that acoustic droplet vaporization is initiated by a combination of two phenomena: highly nonlinear distortion of the acoustic wave before it hits the droplet and focusing of the distorted wave by the droplet itself. At high excitation pressures, nonlinear distortion causes significant superharmonics with wavelengths of the order of the droplet size. These superharmonics strongly contribute to the focusing effect; therefore, the proposed mechanism also explains the observed pressure thresholding effect. Our interpretation is validated with experimental data captured with an ultrahigh-speed camera on the positions of the nucleation spots, where we find excellent agreement with the theoretical prediction. Moreover, the presented mechanism explains the hitherto counterintuitive dependence of the nucleation threshold on the ultrasound frequency. The physical insight allows for the optimization of acoustic droplet vaporization for therapeutic applications, in particular with respect to the acoustic pressures required for activation, thereby minimizing the negative bioeffects associated with the use of high-intensity ultrasound.
Corrigendum: There Is (Scientific) Strength in Numbers: A Comprehensive Quantitation of Fc Gamma Receptor Numbers on Human and Murine Peripheral Blood Leukocytes (2022)

[This corrects the article DOI: 10.3389/fimmu.2020.00118.].
Zurück ins Leben: Transdisziplinäre Traumaforschung - Physische und psychische Traumen verstehen, behandeln, vermeiden (2014)

An der Universität Ulm und in der Region vorhandene Einrichtungen beleuchten alle Facetten von Trauma, vom physischen Trauma, das durch äußere Gewalteinwirkung wie zum Beispiel aufgrund von Verkehrs-, Sport- und Arbeitsunfällen entsteht, bis hin zum psychischen Trauma, das durch seelische Verletzungen hervorgerufen wird. Zwischen körperlichen und seelischen Verletzungen besteht ein enger Zusammenhang. Das Ulmer Ziel ist es, die komplexen Schädigungs- und Heilungsmechanismen besser zu verstehen, neue Therapien zu entwickeln und Langzeitschäden zu verringern. Die sich komplementär ergänzenden Expertisen der renommierten, international bekannten Ulmer Forscherinnen und Forscher sowie Ärztinnen und Ärzte ermöglichen eine einzigartige Verzahnung von Grundlagen-, translationaler und klinischer Traumaforschung.
Arbitrarily polarized microwave power transmission technologies (2016)

Arbitrarily polarized microwave power transmission technologies including polarization auto-matching retrodirective transmitting method and arbitrarily polarized microwave rectenna are proposed in this paper. The polarization auto-matching retrodirective transmitting method using phase conjugating circuits and polarization rotators can receive any polarized pilot signal and generate predictable polarized beam aimed back to the rectenna. The arbitrarily polarized microwave rectenna introducing a directional coupler between dual-polarized antenna and rectifying circuits can receive any polarized microwave and equally distribute it to two rectifying circuits to maintain high rectifying efficiency.
Cost-Effectiveness Analysis of an Intranasal Influenza Vaccine for the Prevention of Influenza in Healthy Children (2001)

Routine use of intranasal influenza vaccine among healthy children may be cost-effective and may be maximized by using group-based vaccination approaches. cost-effectiveness, influenza, vaccine, children.
Novel aspects on the reaction of trialkyl-(1-methylindol-2-yl)borates (1989)

A new use of trialkyl-(1-methylindol-2-yl)borates for the synthesis of 2-substituted indoles involving the palladium catalysed cross-coupling with vinylic and aromatic halides, or a facile alkyl migration from boron to carbon without an additional electrophile is described.
Aproximación psicodramática a las psicosis. (1989)

Se ubica la psicosis dentro de la metapsicologia psicodramatica. Se describe la influencia en la psicoterapia de las psicosis de: la Tecnica del Doble, del Espejo y su relacion con la Fase del Espejo de Lacan, la dramatizacion de las crisis, la preparacion del alta y el juego con los roles temidos, la psicoterapia de las alucinaciones, la representacion de la muerte y la terapia de pareja con escultura. Se concluye destacando la funcion delpsicodrama en la practica asistencial comunitaria.
Experimental investigation of energy properties forStigonematalessp. microalgae as potential biofuel feedstock (2018)

Microalgae has been considered potential biofuel source from the last decade owing to its versatile perspectives such as excellent capability of CO2 capture and sequestration, water treatment, prolific growth rate and enormous energy content. Thus, energy research on microalgae is being harnessed to mitigate CO2 and meet future energy demands. This study investigated the bioenergy potential of native blue-green microalgae consortium as initial energy research on microalgae in Brunei Darussalam. The local species of microalgae were assembled from rainwater drains, the species were identified as Stigonematales sp. and physical properties were characterised. Sundried biomass with moisture content ranging from 6.5% to 7.37% was measured to be used to determine the net and gross calorific value and they were 7.98 MJ/kg-8.57 MJ/kg and 8.70 MJ/kg-9.45 MJ/kg, respectively. Besides that, the hydrogen content, ash content, volatile matter, and bulk density were also experimented and they were 2.56%-3.15%, 43.6%-36.71%, 57–38%-63.29% and 661.2 kg/m3-673.07 kg/m3, respectively. Apart from experimental values, other physical bioenergy parameters were simulated and they were biomass characteristic index 61,822.29 kg/m3-62,341.3 kg/m3, energy density 5.27 GJ/m3-5.76G J/m3 and fuel value index 86.19–88.54. With these experimental results, microalgae manifested itself a potential source of biofuel feedstock for heat and electricity generation, a key tool to bring down the escalated atmospheric greenhouse gases and an alternation for fossil fuel.
Experimental Investigation on Dynamic Stiffness of Damaged Synthetic Fiber Ropes for Deepwater Moorings (2015)

To understand the evolution of dynamic stiffness of damaged synthetic fiber mooring ropes, experimental investigations of polyester and high modulus polyethylene (HMPE) ropes are systematically performed utilizing a specially designed experimental system. An experimental procedure is proposed and test results show that the dynamic stiffness increases with increasing mean load and loading cycles, while decreases with increasing strain amplitude and damage level. The similarity criterion of dynamic stiffness is derived from the dimensional analysis for damaged ropes and verified by experiments. An empirical expression that accounts for the damage, mean load, strain amplitude, and loading cycles is proposed to describe the damage effect upon dynamic stiffness of synthetic fiber mooring ropes.
Experimental evaluation of antiulcer and gastrointestinal effects of Bridelia ferruginea stem bark (2010)

The methanol extract (ME) of dried powdered stem bark of B. ferruginea obtained by 48 hr cold maceration was subjected to solvent guided fractionation in a silica gel column using petroleum ether, dichloromethane and methanol successively to yield the petroleum ether (PF), dichloromethane (DCMF) and methanol (MF) fractions. The extract (ME) and fractions (DCMF and MF) were assessed for antiulcer activity using indomethacin and ethanol induced ulcers in rats. The effects of the extract and fractions on small intestinal transit was studied using charcoal meal test, also the effect of extracts and fractions on isolated guinea pig ileum and acetylcholine induced contractions of the isolated guinea pig ileum were studied. The extracts and fractions were assessed for acute toxicity and lethality (LD50)1 and phytochemical constituents (2,3). Collected data were analyzed using one way ANOVA and further subjected to LSD Post Hoc tests. The extract (200 and 400mg/kg) and fractions (200 and 400mg/kg) significantly (P&lt;0.05) protected the rats against ethanol and indomethacin-induced ulcers, and inhibited small intestinal propulsion in the order DCMF &gt;MF&gt;ME. In addition, MF (0.03–4.27mg/ml) elicited no inhibition, while DCMF(3.3–27µg) antagonized acetylcholine-induced contractions of the guinea pig ileum; whereas ME (0.03–4.27mg/ml) contracted the guinea pig ileum. Oral LD 50 was estimated to be 2,154mg/kg. The results suggest that the stem bark of Bridelia ferruginea contains constituents with antiulcer potency, in addition to non-polar spasmolytic and polar spasmogenic constituents.
Novel gas-stabilized iron clusters: synthesis, structure and magnetic behaviour (2008)

Full text of this item is not currently available on the LRA. &#13;\nThe final published version is available at http://www.iop.org/EJ/abstract/0957-4484/19/50/505602/ Doi: 10.1088/0957-4484/19/50/505602
Different Activities of Viral Enhancer Elements before and after Stable Integration of Transfected DNAs (1987)

Analysis of the RNA and DNA levels of a selectable gene linked to a murine retroviral enhancer demonstrated a correlation between RNA levels and tissue-specific enhancer activity during transient expression in T cells but not in stably transformed cell lines.
Software-hardware co-design for fast and scalable training of deep learning recommendation models (2022)

Deep learning recommendation models (DLRMs) have been used across many business-critical services at Meta and are the single largest AI application in terms of infrastructure demand in its data-centers. In this paper, we present Neo, a software-hardware co-designed system for high-performance distributed training of large-scale DLRMs. Neo employs a novel 4D parallelism strategy that combines table-wise, row-wise, column-wise, and data parallelism for training massive embedding operators in DLRMs. In addition, Neo enables extremely high-performance and memory-efficient embedding computations using a variety of critical systems optimizations, including hybrid kernel fusion, software-managed caching, and quality-preserving compression. Finally, Neo is paired with ZionEX, a new hardware platform co-designed with Neo's 4D parallelism for optimizing communications for large-scale DLRM training. Our evaluation on 128 GPUs using 16 ZionEX nodes shows that Neo outperforms existing systems by up to 40× for training 12-trillion-parameter DLRM models deployed in production.
Monobore Solid Expandable Liners - Redesigning wells for a more Economical and Operational Benefit (2011)

Abstract Solid expandables liners have historically been viewed as contingency liners when operators encounter trouble zones, whether due to setting a conventional casing string high or covering unstable or loss of circulation zones or to improve drilling margins. In that event, the method of operation changes from drilling the well to saving it and still reaching total depth (TD) with the designed production string. At this point the expandable liner typically is run in a high-risk situation when the operator is attempting to save the well. It is more beneficial to design expandable system(s) in a hole section further up the wellbore where the liner would be run in a much lower risk environment. Designing a monobore solid expandable liner into the casing program enables the operator to significantly reduce risks by incorporating another liner string in the well design without losing hole size. Additional benefits can be achieved as the liner requires less pressure to expand rather than running a smaller liner where expansion pressures are higher, reducing associated operational risks. Alternatively, the monobore design can also reduce the number of casing strings run to TD by drilling smaller holes and using less mud and cement while maintaining the same size completion. This type of well construction methodology can lower the overall cost of the well and enable a smaller rig to drill a deeper hole. This methodology enables operators to use conventional high-strength casing to address high-pressure trouble zones further down hole where the expandable liner capabilities may be exceeded. This paper will discuss operators' original basis of designs (BoD) of several application types, the redesigns to incorporate expandable monobore well systems, and the economical benefits they provide. Introduction Although the use of conventional solid expandable liners can result in significant conservation of hole size and "slowing" the telescoping effect of the wellbore (York 2008) as illustrated in Figure 1, some inside diameter (ID) reduction always occurs. The resulting non-API ID of the expanded liner can drive up well construction cost due to the relative scarcity of subsequent drilling equipment such as drill bits, bottomhole drilling assemblies (BHAs), and even retrievable test-treat-squeeze (RTTS) tools and packers. The use of expandable monobore liners can eliminate the need for these "odd" size equipment requirements. Since introducing solid expandable liners in 1999 (Filippov 1999), end users have looked to expandables to not only extend casing shoes with drilling liners, but to do so without sacrificing any hole size in the process. This methodology is being implemented in several arenas and in several available sizes (York 2004, Jabs 2004, Filippov 2005). The monobore term, in reference to expandable technology, is defined as a solid expandable liner that when installed does not result in the loss of diameter of the wellbore (Figure 2).
Die Umlagerung von Oxalodinitril‐bis‐aryliminen (1971)

Abstract Oxalodinitril‐bis‐arylimine 2 können aus den entsprechenden Hydrazidchloriden durch Dehydrohalogenierung in situ dargestellt und mit Dipolarophilen abgefangen werden. In Abwesenheit der letzteren dimerisieren 2 (Aryl = Phenyl oder o ‐Tolyl) zu meso‐ionischen 1.2.4.5‐Tetraaza‐pentalenen 17 , einem bisher unbekannten heteroaromatischen System. Das sterisch stark gehinderte 2c (Aryl = 2.6‐Dimethyl‐phenyl) lagert sich intramolekular in 2‐[2.6‐Dimethyl‐phenylimino]‐2‐[7‐methyl‐indazolyl‐(2)]‐acetonitril ( 25 ) um. Der Mechanismus dieser Reaktionen wird diskutiert.
3-D Monte Carlo surface wave tomography (2018)

Seismic surface wave tomography is a tried and tested method to reveal the subsurface structure of the Earth. However, the conventional 2-step scheme of inverting first for 2-D maps of surface wave phase or group velocity and then inverting for the 3-D spatial velocity structure preserves little information about lateral spatial correlations, and introduces additional uncertainties and errors into the 3-D result. We introduce a 1-step 3-D non-linear surface wave tomography method that removes these effects by inverting for 3-D spatial structure directly from frequencydependent traveltime measurements. We achieve this using the reversible jump Markov chain Monte Carlo (McMC) algorithm with a fully 3-D model parametrization. Synthetic tests show that the method estimates the velocity model and associated uncertainties significantly better than the conventional 2-step McMC method, and that the computational cost seems to be comparable with 2-step McMC methods. The resulting uncertainties are more intuitively reasonable than those from the 2-step method, and provide directly interpretable uncertainty on volumetrics of structures of interest.
ChemInform Abstract: Synthesis of Triazolothienopyrimidine Derivatives. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.