gebhart/patrepeval huggingface dataset:
Unicompartmental Arthroplasty of the Knee (1987)

One hundred consecutive medial compartment knee arthroplasties for osteoarthritis were reviewed for overall clinical result and postoperative alignment. Follow-up evaluation ranged from 24 to 123 months with 51 months being the median. The Marmor knee rating system was used. The alignment of the knee relative to the mechanical axis of the leg (center of the femoral head to the midpoint of the ankle mortise) was determined by a standing three-foot roentgenogram. Of the arthroplasties, 90% were excellent or good results. Superior results were obtained when the mechanical axis fell in the center of the knee (Zone C) or slightly medial to the center (Zone 2). Causes of failure included fractures, femoral component loosening, and excessive lateral compartment or patellofemoral wear. Cartier and Villers' preoperative templating system was modified for intraoperative alignment with the mechanical axis falling into Zone C or Zone 2.
O DNA como (Única) Testemunha em Determinação de Paternidade (2009)

A necessidade de se estabelecer relacoes de paternidade frequentemente surge em contextos legais, sociais ou medicos. Como a concepcao ocorre no interior do corpo da mulher e nao admite testemunhas, a unica maneira de resolver efetivamente o problema e atraves de testes geneticos. Em especial, os testes em DNA nos permitem resolver disputas de paternidade com certeza em praticamente todos os casos - o que pode ser conseguido atraves do uso apropriado de sondas multilocais de minissatelites, baterias de sondas unilocais ou testes por PCR em locos de minissatelites e microssatelites. As diferencas de eficiencia dessas diferentes tecnicas podem ser compensadas mediante o ajuste do numero de testes realizados. Neste artigo, fazemos uma breve revisao discutindo as vantagens e desvantegens de cada uma das tres metodologias mais utilizadas para a determinacao de paternidade pelo DNA. Nesta base, propomos criterios que podem ser empregados para avaliar a confiabilidade de laboratorios de determinacao de paternidade. Finalmente, enfatizamos que a pericia de deterninacao de paternidade e inalienavelmente um ato medico, alicercado tanto em capacitacao etica quanto tecnica - na qual a atuacao desavisada de profissionais inadequadamente formados nos aspectos eticos e medico-legais da determinacao de paternidade pode levar a resultados desastrosos.
A Simple Liquid-Immersed Dielectric Motor (1968)

Measurements have been made on a simple motor consisting of a cylindrical dielectric rotor supported between two plane electrodes and immersed in a semi-insulating liquid. The experimental speed-voltage characteristics are in good general agreement with a theory in which it is postulated that free charge attaches to the rotor surface, as a result of bipolar conduction in the liquid. Following rotor motion, the axes of the electric field and the charge maxima are no longer coincident and there is a net driving torque. The no load operating speed is determined by the balance of this driving torque and the torque due to viscous drag.
Identification and Evaluation of Novel Drug Targets against the Human Fungal Pathogen Aspergillus fumigatus with Elaboration on the Possible Role of RNA-Binding Protein (2017)

Our bioinformatics approach revealed a number of fungal-specific proteins that may be considered as new targets for drug discovery purposes. Peptidylprolyl isomerase, as a possible drug target, was evaluated against two potential inhibitors and the promising results were investigated mechanistically. Future studies would confirm the impact of such target on the antifungal discovery investigations.
Bibliography of FACTS: 2001 - Part I IEEE Working Group Report (2007)

This paper presents a Bibliography of Flexible AC Transmission Systems (FACTS) for the year 2001.
Recent Advances in Chemical Tools for the Regulation and Study of Protein Lysine Methyltransferases (2018)

Protein lysine methyltransferases (PKMTs) are epigenetic regulators that modulate gene transcription and physiological functions by catalyzing the post-translational methylation of specific lysine residues of substrate proteins, such as histones. They are considered to be candidate drugs for the treatment of various diseases, including acute myeloid leukemia, and in the past decade, potent and selective inhibitors of individual PKMTs have been developed. Some are currently under clinical trial. In this review, we will focus on some breakthrough PKMT inhibitors, and discuss chemistry-based methods available for elucidation of the physiological functions of PKMTs and methylated proteins.
Fault diagnosis in designs with convolutional compactors (2005)

The paper introduces a new non-adaptive fault diagnosis technique for scan-based designs. The proposed scheme guarantees accurate and time-efficient identification of failing scan cells based on results of a convolutional test response compaction.
A Two-step Model for Lipoprotein(a) Formation (1995)

Lipoprotein(a) (Lp(a)), a risk factor for coronary artery disease, is a LDL-like particle with apolipoprotein(a) (apo(a)) covalently linked to apolipoprotein B (apoB), the main protein component of LDL. Apo(a) is highly homologous to plasminogen and its gene probably arose by duplication of the plasminogen gene. It has many repeats of kringle-4-like domain, classified as type 1 through type 10 (T1-T10). T9 is responsible for the covalent linkage between apo(a) and LDL. However, we found that T9 has no affinity for LDL. Therefore, an initial noncovalent interaction between apo(a) and LDL is necessary to bring T9 and LDL together. T6 and possibly T7 of apo(a) were identified as the kringles which mediate this initial interaction. With these findings, a two-step model for Lp(a) formation is proposed. This model should be useful in the design of Lp(a) formation inhibitors. These inhibitors are potential antihyperlipoprotein(a) drugs.
Pituitary Tumor Transforming Gene (PTTG) Regulates Placental JEG-3 Cell Division and Survival: Evidence from Live Cell Imaging (2000)

The pituitary transforming gene, PTTG, is abundantly expressed in endocrine neoplasms. PTTG has recently been recognized as a mammalian securin based on its biochemical homology to Pds1p. PTTG expression and intracellular localization were therefore studied during the cell cycle in human placental JEG-3 cells. PTTG mRNA and protein expressions were low at the G1/S border, gradually increased during S phase, and peaked at G2/M, but PTTG levels were attenuated as cells entered G1. In interphase cells, wild-type PTTG, an epitope-tagged PTTG, and a PTTG-EGFP conjugate all localized to both the nucleus and cytoplasm, but in mitotic cells, PTTG was not observed in the chromosome region. PTTG-EGFP colocalized with mitotic spindles in early mitosis and was degraded in anaphase. Intracellular fates of PTTG-EGFP and a conjugate of EGFP and a mutant inactivated PTTG devoid of an SH3-binding domain were observed by real-time visualization of the EGFP conjugates in live cells. The same cells were continuously observed as they progressed from G1/S border to S, G2/M, and G1. Most cells (67%) expressing PTTG-EGFP died by apoptosis, and few cells (4%) expressing PTTG-EGFP divided, whereas those expressing mutant PTTG-EGFP divided. PTTG-EGFP, as well as the mutant PTTG-EGFP, disappeared after cells divided. The results show that PTTG expression and localization are cell cycle-dependent and demonstrate that PTTG regulates endocrine tumor cell division and survival.
Charge-accumulative Potentiometric Measurements for Ammonia Detection Using an Enzymatic Cascade Reaction on a Prussian Blue Electrode (2018)

To detect ammonia using an electrochemical method, we developed a sensor chip consisting of l-glutamate dehydrogenase, l-glutamate oxidase, and a Prussian blue–carbon electrode. When the enzyme electrode was applied to potentiometric and amperometric ammonia measurements, the limits of detection were 0.2 µM and 2,100 µM, respectively. Thus, potentiometric measurements, in which the charge produced by the enzymatic reaction accumulates on the electrode, allow more sensitive detection of ammonia than amperometric measurements, in which the charge passes through the electrode. To realize ammonia sensing using an electrochemical method, we developed a sensor chip consisting of l-glutamate dehydrogenase, l-glutamate oxidase, and a Prussian blue–carbon electrode. When the enzyme electrode was applied to potentiometric ammonia measurements, the limit of detection was 0.2 µM, which is sensitive enough to measure the blood ammonia concentration of a healthy person.
ANNIDS: intrusion detection system based on artificial neural network (2004)

This paper describes a network intrusion detection system based on artificial neural network (ANNIDS). The advantage of neural network ensures that ANNIDS does not need expert knowledge and it can find unknown or novel intrusions. The key part of ANNIDS is an adaptive resonance theory neural network (ART). ANNIDS can be trained in real-time and in an unsupervised way. A weight hamming distance method is used in detection, which is simple and correct in finding anomalous behavior. A well-trained ANNIDS can monitor the network in real time. The experimental results show that ANNIDS performs best when vigilance parameter is 0.4 to 0.5 and intrusion threshold is 0.4. The false positive error is about 8%, the negative error is about 2%, and the total error is lower 10%.
Correction to: Exome sequencing reveals a novel PLP1 mutation in a Moroccan family with connatal Pelizaeus-Merzbacher disease: a case report (2018)

After publication of the original article [1] it was brought to our attention that author Bouchra Ouled Amar Bencheikh was incorrectly included as Bouchra Oulad Amar Bencheikh.
Frame synchronization of satellite based on AIS signals (2016)

Frame synchronization play a very important role in coding of AIS. There are much arithmetic like maximum-likelihood, correlation and so on. But most of those cannot achieve good performance with large frequency offset. As satellite-based AIS system exist larger time delay and Doppler frequency offset, this paper propose arithmetic of frame synchronization. It is based on folding auto-correlation, where the top half and second half of training sequence have largest correlation after it is modulated by GMSK. Simulation experiments indicate that this arithmetic has good anti-frequency-offset performance.
A Report of the Association for Molecular Pathology (2009)

From the Whole Genome Analysis Working Group, Association for Molecular Pathology Clinical Practice Committee,* Bethesda, Maryland; the Departments of Pathology and Pediatrics, Stanford University School of Medicine, Stanford, California; the Department of Transformation Program Office, College of American Pathologists, Northfield, Illinois; the Department of Clinical Diagnostics, Sequenom Center for Molecular Medicine, Grand Rapids, Michigan; the Department of Molecular Medicine, Life Technologies, Foster City, California; the Department of Pathology, Virginia Commonwealth University, Richmond, Virginia; the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska; the Department of Pathology and Laboratory Medicine, University of California, Los Angeles School of Medicine, Los Angeles, California; Illumina Clinical Services Lab, San Diego, California; the Division of Laboratory Science and Standards, Centers for Disease Control and Prevention, Atlanta, Georgia; the Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Molecular Oncology, BloodCenter of Wisconsin, and the Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin; the Department of Pathology and Laboratory Medicine,* Weill Cornell Medical College, New York, New York; the Department of Pathology, University of Utah/ARUP Laboratories, Salt Lake City, Utah; Esoterix Genetic Laboratories, LLC, Westborough, Massachusetts; Molecular Genetics, Quest Diagnostics, Nichols Institute, Chantilly, Virginia; the American Society of Investigative Pathology, Bethesda, Maryland; the Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah; the ARUP Institute for Experimental and Clinical Pathology, Salt Lake City, Utah; and the Department of Clinical Sciences–Pathology, University of Central Florida College of Medicine, Orlando, Florida
ADP-induced platelet aggregation depends on the conformation or availability of the terminal gamma chain sequence of fibrinogen. Study of the reactivity of fibrinogen Paris 1 (1987)

Fibrinogen Paris I contains a mutant gamma chain that is longer than the normal chain, resulting in altered fibrin polymerization and cross-linking. Because these functions involve the carboxy-terminal region of the gamma chain, we decided to determine whether fibrinogen Paris I or the isolated Paris I gamma chain supports normal ADP-induced platelet aggregation, a function that requires the ultimate 12 residues of the normal gamma chain (400 through 411). Aggregation of ADP-stimulated normal platelets was defective with fibrinogen Paris I and markedly depressed with the gamma Paris I chain. These findings prompted us to characterize the carboxy-terminal structure of the region of the gamma Paris I chain responsible for this activity. The carboxy-terminal cyanogen bromide (CNBr) peptide of the normal gamma chain (385 through 411) or that from gamma Paris I was isolated by differential adsorption to triethylene-tetramine resin or by reverse-phase high-performance liquid chromatography (HPLC). The CNBr peptide from the Paris I gamma chain was identical to that of the normal gamma chain in its retention time on HPLC, its amino acid composition, and its sequence. Thus, the primary structure of the gamma Paris I chain from residue 384 through 411 is normal, indicating that a peptide insertion has occurred upstream from residue 384, resulting in an impairment of those physiologic functions attributable to the carboxy-terminal end of the gamma chain from position 384 (ie, cross-linking, ADP-induced platelet aggregation, and at least a portion of the gamma chain polymerization site). These observations demonstrate that the gamma chain platelet recognition site in the fibrinogen molecule is necessary but not alone sufficient to support normal ADP-induced platelet aggregation. There appears to be an additional requirement for normal conformation of the gamma chain or availability of its terminal sequence during the interaction of fibrinogen with platelets.
Machinable Rogowski coil, design, and calibration (1996)

Rogowski coils are special types of mutual inductors often used to measure high AC and transient currents. Traditional designs are reviewed. The significant sources of error associated with typical coil designs are examined. A "machinable Rogowski coil" is introduced and discussed. The reasoning behind critical design choices is discussed. The improved performance of the machinable coil is compared to that of other designs. Test and calibration methods are discussed.
Intracranial delivery of AAV9 gene therapy partially prevents retinal degeneration and visual deficits in CLN6-Batten disease mice (2021)

Batten disease is a family of rare, fatal, neuropediatric diseases presenting with memory/learning decline, blindness, and loss of motor function. Recently, we reported the use of an AAV9-mediated gene therapy that prevents disease progression in a mouse model of CLN6-Batten disease (<i>Cln6</i> <sup><i>nclf</i></sup> ), restoring lifespans in treated animals. Despite the success of our viral-mediated gene therapy, the dosing strategy was optimized for delivery to the brain parenchyma and may limit the therapeutic potential to other disease-relevant tissues, such as the eye. Here, we examine whether cerebrospinal fluid (CSF) delivery of scAAV9.CB.CLN6 is sufficient to ameliorate visual deficits in <i>Cln6</i> <sup><i>nclf</i></sup> mice. We show that intracerebroventricular (i.c.v.) delivery of scAAV9.CB.CLN6 completely prevents hallmark Batten disease pathology in the visual processing centers of the brain, preserving neurons of the superior colliculus, thalamus, and cerebral cortex. Importantly, i.c.v.-delivered scAAV9.CB.CLN6 also expresses in many cells throughout the central retina, preserving many photoreceptors typically lost in <i>Cln6</i> <sup><i>nclf</i></sup> mice. Lastly, scAAV9.CB.CLN6 treatment partially preserved visual acuity in <i>Cln6</i> <sup><i>nclf</i></sup> mice as measured by optokinetic response. Taken together, we report the first instance of CSF-delivered viral gene reaching and rescuing pathology in both the brain parenchyma and retinal neurons, thereby partially slowing visual deterioration.
The Effect of Obesity on Pain Severity and Pain Interference (2020)

ABSTRACT Background and objectives Obesity is one of the most prevalent comorbidities associated with chronic pain, the experience of which can severely interfere with activities of daily living and increase the utilization of clinical resources. Obesity is also a risk factor for increased pain severity (pain intensity) and pain interference (pain related disability). We hypothesize that a higher level of obesity, as measured by body mass index (BMI), would be associated with increased levels of pain severity and interference in a population of chronic pain clinic patients. Methods Participant data was pulled from a multi-site chronic pain outpatient database from 7/8/2011 to 10/17/2016. The Brief Pain Inventory (BPI), opioid prescriptions, and basic demographic information were queried and we categorized participants into three different ordinal categories based on recorded BMI levels (underweight, normal and overweight, obese). Bivariate analyses were performed to compare pain outcomes by BMI and by other demographic/clinical patient characteristics. Multivariable linear regressions were constructed to model each of four pain severity scores in addition to total pain interference score. All models examined BMI as the primary predictor, controlling for age, receipt of a pain procedure within 45 days prior to the pain clinic encounter, opioid prescription within 45 days prior to the encounter, and diagnosis. The total pain interference model additionally included pain severity (as measured by worst pain in the past 24 hours) as a covariate. Results 2509 patients were included in the study. The median BMI was 27 and the median age was 59 years. 77% of patients were diagnosed with musculoskeletal pain conditions. Bivariate tests revealed significant differences between BMI groups for all pain severity scores and for total pain interference score. On multivariable modelling controlling for age, pain procedure within 45 days prior to pain clinic encounter, opioid prescription with 45 days prior, and diagnosis, obese patients had significantly higher pain severity (as measured by worst, least, average, and current pain in the past 24 hours) as well as higher pain interference (as measured by the overall pain interference score) than normal weight and overweight patients. Conclusion In our study of pain clinic patients, obesity was found to be associated with increased pain severity and pain interference. We believe that this relationship is multifactorial and bidirectional. Pain phyisicans should consider the impact of obesity when addressing pain management for patients.
Severe muscular dystrophy in mice that lack dystrophin and α7 integrin (2006)

The dystrophin glycoprotein complex links laminin in the extracellular matrix to the cell cytoskeleton. Loss of dystrophin causes Duchenne muscular dystrophy, the most common human X-chromosome-linked genetic disease. The alpha7beta1 integrin is a second transmembrane laminin receptor expressed in skeletal muscle. Mutations in the alpha7 integrin gene cause congenital myopathy in humans and mice. The alpha7beta1 integrin is increased in the skeletal muscle of Duchenne muscular dystrophy patients and mdx mice. This observation has led to the suggestion that dystrophin and alpha7beta1 integrin have complementary functional and structural roles. To test this hypothesis, we generated mice lacking both dystrophin and alpha7 integrin (mdx/alpha7(-/-)). The mdx/alpha7(-/-) mice developed early-onset muscular dystrophy and died at 2-4 weeks of age. Muscle fibers from mdx/alpha7(-/-) mice exhibited extensive loss of membrane integrity, increased centrally located nuclei and inflammatory cell infiltrate, greater necrosis and increased muscle degeneration compared to mdx or alpha7-integrin null animals. In addition, loss of dystrophin and/or alpha7 integrin resulted in altered expression of laminin-alpha2 chain. These results point to complementary roles for dystrophin and alpha7beta1 integrin in maintaining the functional integrity of skeletal muscle.
Anatomic and Clinical Study of the Orbitopterional Approach to Anterior Communicating Artery Aneurysms (2003)

Abstract OBJECTIVE To evaluate the orbitopterional approach to anterior communicating artery (AComA) aneurysms, on the basis of the quantification of this surgical exposure, compared with the pterional approach, in a cadaveric study and a retrospective review of data for 40 patients who underwent clipping of AComA aneurysms via the orbitopterional approach. METHODS In an anatomic study, four cadaveric heads underwent pterional craniotomies on the left side and orbitopterional craniotomies on the right side. A fifth head was initially subjected to bilateral pterional craniotomies and then underwent bilateral orbital osteotomies, for direct comparison of these approaches. Using frameless stereotaxy, we quantified the angles of exposure and surgical field depths provided by the pterional and orbitopterional craniotomies. In a clinical study, 40 patients who underwent clipping of AComA aneurysms via orbitopterional approaches were evaluated for basal brain injury, the need for resection of the gyrus rectus, dissection of the sylvian fissure, and approach-related complications. The incidence of postoperative hydrocephalus among patients with subarachnoid hemorrhage who underwent lamina terminalis fenestration was also reviewed. RESULTS The angles of observation were increased 46% in the axial plane (orbitopterional, 72.92 ± 6.57 degrees; pterional, 49.75 ± 2.27 degrees; P&amp;lt; 0.01) and 137.5% in the projection plane (orbitopterional, 8 ± 2.19 degrees; pterional, 19 ± 1.78 degrees; P&amp;lt; 0.01). The surgical window depth was decreased 13% with the orbitopterional approach (P&amp;lt; 0.05). Clinically, there was no incidence of frontobasal hypodensities on postoperative computed tomographic scans. Three patients (7.5%) required resection of the gyrus rectus. No patient required sylvian fissure dissection for aneurysm exposure. Two of 29 patients (6.9%) who survived subarachnoid hemorrhage required ventriculoperitoneal shunts despite lamina terminalis fenestration. No approach-related complications were recognized. CONCLUSION The orbitopterional approach improved the observation of the AComA complex and seemed to decrease the risk of intraoperative brain damage.
Androgen receptors, androgen‐dependent proliferation, and 5α‐reductase activity of small‐cell lung cancer cell lines (1989)

We investigated the influence of testosterone on binding to established small-cell lung cancer (SCLC) cell lines and were able to show specific high-affinity and low-capacity binding sites in some cell lines with a typical receptor size, using sucrose density gradient centrifugation. In addition, we demonstrated marked growth stimulation with testosterone and dehydrotestosterone using different androgen-receptor-positive small-cell lung cancer cell lines. This growth stimulation could be counteracted by the addition of anti-androgens like cyproterone acetate or flutamide. The presence of 5 alpha-reductase activity, 17 beta-hydroxysteroid-dehydrogenase and 3 alpha-hydroxysteroid-dehydrogenase activities could be demonstrated, suggesting testosterone metabolism of small-cell lung cancer cell lines.