gebhart/patrepeval huggingface dataset:
Recent Advances in Surface Chemical Modification of Cellulose Fibres (2011)

Over the last two decades, our research group has been involved in several approaches for chemical modification of cellulose fibre surfaces, with the aim to reduce their hydrophilic character and/or improve their adhesion strength to matrices in composite materials. Relevant advances were achieved recently by different modification strategies, namely (i) physical treatments, such as plasma; (ii) chemical grafting by click chemistry or by using polyether and polyester grafts and (iii) direct silanol-cellulose condensation with a prior hydrolysis treatment. The characterisation of the modified surfaces was performed using different characterisation techniques. The grafted materials were evaluated by elemental analysis, contact angle measurements, scanning electron microscopy, 13C-NMR CP-MAS, FTIR and X-ray photoelectron spectroscopy. The present paper reports the most relevant advances in the field of surface chemical modification of cellulose fibres achieved by our group over the last two years.
Network Kriging (2006)

Network service providers and customers are often concerned with aggregate performance measures that span multiple network paths. Unfortunately, forming such network-wide measures can be difficult, due to the issues of scale involved. In particular, the number of paths grows too rapidly with the number of endpoints to make exhaustive measurement practical. As a result, it is of interest to explore the feasibility of methods that dramatically reduce the number of paths measured in such situations, while maintaining acceptable accuracy. We cast the problem as one of statistical prediction-in the spirit of the so-called "kriging" problem in spatial statistics-and show that end-to-end network properties may be accurately predicted in many cases using a surprisingly small set of carefully chosen paths. More precisely, we formulate a general framework for the prediction problem, propose a class of linear predictors for standard quantities of interest (e.g., averages, totals, and differences) and show that linear algebraic methods of subset selection may be used to effectively choose which paths to measure. We characterize the performance of the resulting methods, both analytically and numerically. The success of our methods derives from the low effective rank of routing matrices as encountered in practice, which appears to be a new observation in its own right with potentially broad implications on network measurement generally
Mining parametric specifications (2011)

Specifications carrying formal parameters that are bound to concrete data at runtime can effectively and elegantly capture multi-object behaviors or protocols. Unfortunately, parametric specifications are not easy to formulate by nonexperts and, consequently, are rarely available. This paper presents a general approach for mining parametric specifications from program executions, based on a strict separation of concerns: (1) a trace slicer first extracts sets of independent interactions from parametric execution traces; and (2) the resulting non-parametric trace slices are then passed to any conventional non-parametric property learner. The presented technique has been implemented in jMiner, which has been used to automatically mine many meaningful and non-trivial parametric properties of OpenJDK 6.
Operational Improvements in Image Orthicon Camera Equipment (1963)

A modern broadcast TV Camera adaptable for use with either 3-inch or 4 1/2-inch image orthicon tubes is described. Circuit and mechanical innovations are discussed which result in improved stability and reliability. Simplified operation and maintenance of the camera are emphasized.
A Study of the Switched Reluctance Motor using Grain-Oriented Electrical Steel Sheets (2020)

High torque density and high efficiency of Switched Reluctance Motor (SRM) are required. In this paper, An SRM using Grain-Oriented electrical steel sheets (GO) is proposed. The GO has been paid an attention because of its low iron loss characteristic and high magnetic flux density in the saturation area. The GO is a soft magnetic material which magnetic flux is easily through in a specific direction. Also, three kinds of torques can be used, which are a reluctance torque by the saliency, a reluctance torque by the difference of magnetic permeability, and a torque by the magnetic anisotropy. The torque by the magnetic anisotropy is generated by rotating of each magnetization vector.In this research, two kinds of the SRM are proposed. One is the SRM having two poles rotor, and the other one is the SRM having a cylindrical rotor. The number of poles is set to two poles to confirm that the torque of the SRM using the GO is higher than that of the SRM using Non-Oriented electrical steel sheets (NO). On the other hand, the SRM having a cylindrical rotor is designed to reduce the windage loss in the high speed area. It can be rotated by the reluctance torque generated by the difference of magnetic permeability and the torque generated by magnetic anisotropy.
African-American Trailblazers: The Sociopolitical Factors of Success (2011)

have four incredibly supportive parents and may not be completing this without my mother, father, and their respective spouses, Bill and Martha.My little brothers,
A first-in-human dose-escalation study of ME-143, a second generation NADH oxidase inhibitor, in patients with advanced solid tumors (2013)

ME-143 was well-tolerated when administered intravenously at the maximally administered/recommended phase 2 dose of 20 mg/kg once weekly to patients with advanced solid tumors. Though limited clinical activity was observed with monotherapy, inhibitors of tumor-specific NADH oxidase such as ME-143 may derive their greatest benefit in combination with cytotoxic chemotherapy.
In Vitro Nasal Tissue Model for the Validation of Nasopharyngeal and Midturbinate Swabs for SARS-CoV-2 Testing (2022)

Large-scale population testing is a key tool to mitigate the spread of respiratory pathogens, such as the current COVID-19 pandemic, where swabs are used to collect samples in the upper airways (e.g., nasopharyngeal and midturbinate nasal cavities) for diagnostics. However, the high volume of supplies required to achieve large-scale population testing has posed unprecedented challenges for swab manufacturing and distribution, resulting in a global shortage that has heavily impacted testing capacity worldwide and prompted the development of new swabs suitable for large-scale production. Newly designed swabs require rigorous preclinical and clinical validation studies that are costly and time-consuming (i.e., months to years long); reducing the risks associated with swab validation is therefore paramount for their rapid deployment. To address these shortages, we developed a 3D-printed tissue model that mimics the nasopharyngeal and midturbinate nasal cavities, and we validated its use as a new tool to rapidly test swab performance. In addition to the nasal architecture, the tissue model mimics the soft nasal tissue with a silk-based sponge lining, and the physiological nasal fluid with asymptomatic and symptomatic viscosities of synthetic mucus. We performed several assays comparing standard flocked and injection-molded swabs. We quantified the swab pickup and release and determined the effect of viral load and mucus viscosity on swab efficacy by spiking the synthetic mucus with heat-inactivated SARS-CoV-2 virus. By molecular assay, we found that injected molded swabs performed similarly or superiorly in comparison to standard flocked swabs, and we underscored a viscosity-dependent difference in cycle threshold values between the asymptomatic and symptomatic mucuses for both swabs. To conclude, we developed an <i>in vitro</i> nasal tissue model that corroborated previous swab performance data from clinical studies; this model will provide to researchers a clinically relevant, reproducible, safe, and cost-effective validation tool for the rapid development of newly designed swabs.
Relationship between internalizing and externalizing symptoms trajectories and perinatal risk factors in an epidemiological sample: Preliminary results from the remind project (2021)

Introduction Our 15-years follow-up ReMIND project aims to re-assess an epidemiological and a clinical sample of adults (Wave 3), who were assessed in preadolescence (Wave 1) and adolescence (Wave 2), to evaluate symptoms trajectories and their relationship with genetic/epigenetic data, environmental risk factors and neuroimaging measures. Objectives Here, we depict preliminary results regarding the epidemiological sample. Methods We assessed internalizing and externalizing symptoms in 40 italian subjects (25 F) from general population at three waves (W1 mean age: 12±0,82; W2 mean age: 17±0,88, W3 mean age: 28±1), through the Child Behavior Checklist (W1 and W2) or the Adult Self Report (W3), and perinatal risk factors through a socio-anamnestic questionnaire, by a new online platform (MedicalBit). We analyzed symptoms trajectories and their relation with perinatal risk factors through a repeated measures multivariate analysis of variance (rm-MANOVA). Results rm-MANOVA results show that high number of perinatal risks was significantly associated with higher internalizing symptomatology in preadolescence but not in adolescence and adult life. The mean difference was 8 T-points. The same trend is evident in adolescence but not in adult age (Graph 1). Perinatal risk factors did not have a significant effect on externalizing symptoms at any time point, despite a non-significant trend is evident (Graph 2). Conclusions Our preliminary results suggest a trend of increased internalizing symptoms from childhood to adulthood and a significant role of perinatal risk factors in pre-adolescence. Further investigations are necessary to better understand symptoms trajectories and the role of biological and environmental factors. Disclosure No significant relationships.
Teaching with emerging experience: to develop leadership and innovation skills (2009)

This paper is based on a hands-on session proposed at ALE 2009 Conference (Active Learning for Engineering Education). It presents a teaching practice used at Ecole Centrale Paris (ECP) to foster engineering students’ leadership and innovation skills and to help them going through major paradigm shifts. Considering a class as a human complex system, teachers work in a posture of facilitators or coaches who orchestrate a learning process. Instead of transmitting knowledge as traditional professors, they focus on the relationships in the classroom and the experience emerging from them.
La contaminación transfronteriza en derecho internacional privado: estudio de derecho aplicable (2003)

La presente tesis analiza diversas cuestiones de derecho aplicable que pueden plantearse al hilo de un supuesto de contaminacion transfronteriza. Tras cuestionarse la calificacion de las diversas acciones que cabe ejercitar en materia medioambiental, la tesis analiza que ha de entenderse por locus delicti en supuestos internacionales de polucion. Junto a este punto de conexion han de estudiarse diversos criterios de flexibilizacion que pueden incidir en la materia (residencia habitual, nacionalidad, conexion accesoria, autonomia de la voluntad). Igualmente la tesis examina el ambito del estatuto delictual conflictualmente determinado y tiene en consideracion la incidencia en este sector medioambiental de normas materiales imperativas, normas de conducta y seguridad y autorizaciones administrativas.
Review of the Application of T-Matrix Calculations for Determining the Structure of Cell Nuclei With Angle-Resolved Light Scattering Measurements (2009)

Biomedical applications of light scattering have traditionally relied on Mie theory as a theoretical basis for analyzing experimental measurements. While this approach is computationally accessible, the use of Mie theory cannot always account for the spheroidal nature of biological scatterers such as cell nuclei. As an alternative, we have developed light scattering codes based on the T-matrix formalism to analyze angle-resolved light scattering measurements. In this paper, we discuss the development of computer codes to create a database of scattering profiles, validation of the database using experimental measurements of tissue phantoms containing spheroidal scatterers, and recent applications of the approach to analyze the structure of cell nuclei. The reviewed studies show that while the T-matrix approach adds important information for some light scattering studies, the additional computational cost may not always be justified when compared to the Mie theory.
USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta (2019)

USP22, a component of the SAGA complex, is overexpressed in highly aggressive cancers, but the normal functions of this deubiquitinase are not well defined. We determined that loss of USP22 in mice results in embryonic lethality due to defects in extra-embryonic placental tissues and failure to establish proper vascular interactions with the maternal circulatory system. These phenotypes arise from abnormal gene expression patterns that reflect defective kinase signaling, including TGFβ and several receptor tyrosine kinase pathways. USP22 deletion in endothelial cells and pericytes that are induced from embryonic stem cells also hinders these signaling cascades, with detrimental effects on cell survival and differentiation as well as on the ability to form vessels. Our findings provide new insights into the functions of USP22 during development that may offer clues to its role in disease states.
Enhancement of Antitumor Immunity Using a DNA-Based Replicon Vaccine Derived from Semliki Forest Virus (2014)

A DNA-based replicon vaccine derived from Semliki Forest virus, PSVK-shFcG-GM/B7.1 (Fig. 1a) was designed for tumor immunotherapy as previously constructed. The expression of the fusion tumor antigen (survivin and hCGβ-CTP37) and adjuvant molecular protein (Granulocyte-Macrophage Colony-Stimulating Factor/ GM-CSF/B7.1) genes was confirmed by Immunofluorescence assay in vitro, and immunohistochemistry assay in vivo. In this paper, the immunological effect of this vaccine was determined using immunological assays as well as animal models. The results showed that this DNA vaccine induced both humoral and cellular immune responses in C57BL/6 mice after immunization, as evaluated by the ratio of CD4+/CD8+ cells and the release of IFN-γ. Furthermore, the vaccination of C57BL/6 mice with PSVK-shFcG-GM/B7.1 significantly delayed the in vivo growth of tumors in animal models (survivin+ and hCGβ+ murine melanoma, B16) when compared to vaccination with the empty vector or the other control constructs (Fig. 1b). These data indicate that this type of replicative DNA vaccine could be developed as a promising approach for tumor immunotherapy. Meanwhile, these results provide a basis for further study in vaccine pharmacodynamics and pharmacology, and lay a solid foundation for clinical application.
Phenotype and functional activity of tumor-infiltrating lymphocytes isolated from immunogenic and nonimmunogenic rat brain tumors. (1991)

The purpose of the present study was to define the immunogenicity of two transplantable rat gliomas, designated F98 and D74, and to relate this to the phenotype and functional activity of tumor-infiltrating lymphocytes (TIL). Fischer rats, immunized with irradiated F98 tumor cells and challenged with intracerebral implants of ten F98 cells, had a median survival time of 49 days compared to 36 days for nonimmunized controls. In contrast, no statistically significant increases in survival times were noted in animals similarly immunized and challenged with the D74 tumors. No in vivo protection could be demonstrated in animals immunized and cross-challenged with either F98 or D74 glioma cells. Lymph node lymphocytes and TIL, isolated from animals immunized and challenged with F98 cells, were more cytolytically active than effector cells obtained from D74-immunized animals. Phenotypes of TIL isolated from intracerebral F98 gliomas of immunized rats were 52% OX-8+ and 21% W3/25+ compared to 31% OX-8+ and 19% W3/25+ for D74-immunized animals. Cytolytic activity against glioma targets was mediated by OX-8+ TIL, as determined by cell depletion experiments. Limiting dilution analysis showed that cytolytic T-lymphocyte precursors were present in TIL of F98 gliomas of immunized rats at a frequency of 1/3547 and were specific for F98 targets, while natural killer cell-like activity was low. Our data indicate that the F98 glioma was more immunogenic than the D74 glioma, as evidenced by increased numbers and activity of cytolytic effector cells and their precursors among TIL. This may explain in part the longer survival times observed in immunized animals challenged intracerebrally with the F98 gliomas compared to D74-immunized and -challenged hosts.
Development of a cryocooler conduction-cooled 650 MHz SRF cavity operating at ∼10 MV/m cw accelerating gradient (2022)

Abstract SRF cavities for particle acceleration are conventionally operated immersed in a bath of liquid helium at 4.2 K and below. Although this cooling configuration is practically and economically viable for large scientific accelerator installations, it may not be so for smaller accelerators intended for industrial applications such as the treatment of wastewater, sludge, flue gases, etc. In this paper, we describe a procedure to operate SRF cavities without liquid helium that can be used to construct electron-beam sources for industrial applications of electron irradiation (1-10 MeV electron energy). In this procedure, an elliptical single-cell 650 MHz niobium-tin coated niobium cavity is coupled to a closed-cycle 4.2 K cryocooler using high purity aluminum thermal links. The cryocooler conductively extracts heat (RF dissipation) from the cavity without requiring liquid helium around the cavity. We present construction details of this cryocooler conduction-cooling technique and systematic experiments that have demonstrated ∼10 MV/m cw gradient on the cavity. By straightforward scaling up the cavity length and number of cryocoolers, the technique will provide the complete range of 1-10 MeV electron energy for industrial applications.
Transseptal puncture for left atrial ablation: Risk factors for cardiac tamponade and a proposed causative classification system (2022)

During left atrial ablation, the risk of TRCT was reduced by operator experience, TOE-guidance, and use of a transseptal guidewire, and was increased by patient age, re-do procedures, and failure to cross the septum first pass.
Optical properties and Faraday effects on terbium gallium garnet ceramics for Faraday rotator (2011)

We have measured the optical properties and Faraday effect of ceramic TGG, its Verdet constant at 1064 nm is same as that of single crystal at room temperature.
Fielding and calibration issues for diamond photoconducting detectors (1997)

Diamond photoconducting detectors (PCDs) are routinely fielded as soft x-ray diagnostics on Sandia’s Saturn facility. We have developed an improved detector mount that provides a 200 ps time response, is easily cleanable, and is very rugged. In addition, we have developed a new, fast insertion unit to apply bias voltage to the detectors. Absolute calibration of the PCDs is carried out either at the Brookhaven National Synchrotron Light Source or on Sandia’s laser calibration facility. We are now fielding diamond elements that have the dimensions 1×3×0.5 mm and 1×1×0.5 mm. We are neutron damaging some of the 1×1×0.5 mm detectors to reduce their sensitivity. We can tailor PCD sensitivity by adjusting element size and neutron damage level.
[Clinical evaluation after myocardial infarction. Its role, date and methods]. (1992)

Although global mortality in the year following myocardial infarction is about 10%, this figure varies from less than 1% to more than 50% in some very high risk cases. The principal objective of clinical evaluation during the acute phase is to establish a prognosis and propose a rational strategy for myocardial revascularisation (by bypass grafting or angioplasty) in patients with a poor prognosis. An essential feature of this evaluation is to reduce health care costs and hospital stay to a minimum. Coronary angiography is the only investigation which allows assessment of the coronary circulation and is probably the best method of evaluating global and regional left ventricular function, two essential prognostic factors: on the other hand, it does not provide information about the presence of residual ischaemia or persistent myocardial viability in the infarcted territory. Some very high risk patients should undergo systematic coronary angiography to determine the possibilities for myocardial revascularisation: early post-infarction angina, left ventricular failure, chronic angina, elderly but valid patients... The indications of coronary angiography should also extend to patients with non-Q wave infarction, to young patients with myocardial infarction on thrombolysed infarcts: results of coronary angiography should then be compared with those of standard exercise stress testing. It is only in other situations, concerning a minority of patients, in which two attitudes may be considered: the first, to perform coronary angiography very early (within 24-48 hours of admission) allowing early discharge from hospital of many cases, completed later by standard exercise stress testing: any revascularisation procedure is considered at that time and requires a second hospital admission. The second attitude consists in performing coronary angiography between the 7th and 10th day only if some paraclinical changes are present: exercise stress testing then has an essential role; to improve its negative predictive value for absence of long-term coronary events it should be associated with radionuclide investigation of myocardial perfusion (thallium, MIBI) or with an evaluation or residual myocardial viability (labelled fatty acids, cyclotron). This attitude also allows early identification of "good candidates" for myocardial revascularisation.
More Lipophilic Dialkyldiamine-Based Diazeniumdiolates:  Synthesis, Characterization, and Application in Preparing Thromboresistant Nitric Oxide Release Polymeric Coatings (2003)

The synthesis, characterization, and biomedical application in preparing more thromboresistant polymeric coatings for a series of lipophilic dialkyldiamine-based diazeniumdiolatesare described. Dialkylhexamethylenediamine diazeniumdiolates of the form RN[N(O)NO](-)(CH(2))(6)NH(2)(+)R, where R = CH(3), CH(2)CH(3), (CH(2))(2)CH(3), (CH(2))(3)CH(3), (CH(2))(4)CH(3,) (CH(2))(5)CH(3), and (CH(2))(11)CH(3), are prepared via reaction of the corresponding diamine with NO. The more lipophilic diazeniumdiolates [e.g., R = (CH(2))(3)CH(3)] can be incorporated into hydrophobic polymeric films (e.g., plasticized PVC), and the resulting materials release NO for extended periods of time upon exposure to PBS buffer. The mechanism of NO release from these films is examined in detail. More stable initial NO release can be achieved by adding lipophilic anionic species (e.g., tetraphenylborate derivative) to the polymeric material to buffer the activity of protons within the organic phase. It is shown that the use of these new lipophilic NO-donors in polymers provides the ability to tailor NO release rates for a variety of medical applications. As an example, polymers doped with N,N'-dibutylhexamethylenediamine diazeniumdiolate and a tetraphenylborate derivative are employed as coatings for vascular grafts in sheep. The NO release grafts exhibited enhanced performance and had an average 95% thrombus-free surface area compared to 42% for the corresponding control grafts when examined after 21d of implantation.