gebhart/patrepeval huggingface dataset:
Divergent metabolic programmes control two populations of MAIT cells that protect the lung (2023)

Although mucosal-associated invariant T (MAIT) cells provide rapid, innate-like responses, they are not pre-set, and memory-like responses have been described for MAIT cells following infections. The importance of metabolism for controlling these responses, however, is unknown. Here, following pulmonary immunization with a Salmonella vaccine strain, mouse MAIT cells expanded as separate CD127<sup>-</sup>Klrg1<sup>+</sup> and CD127<sup>+</sup>Klrg1<sup>-</sup> antigen-adapted populations that differed in terms of their transcriptome, function and localization in lung tissue. These populations remained altered from steady state for months as stable, separate MAIT cell lineages with enhanced effector programmes and divergent metabolism. CD127<sup>+</sup> MAIT cells engaged in an energetic, mitochondrial metabolic programme, which was critical for their maintenance and IL-17A synthesis. This programme was supported by high fatty acid uptake and mitochondrial oxidation and relied on highly polarized mitochondria and autophagy. After vaccination, CD127<sup>+</sup> MAIT cells protected mice against Streptococcus pneumoniae infection. In contrast, Klrg1<sup>+</sup> MAIT cells had dormant but ready-to-respond mitochondria and depended instead on Hif1a-driven glycolysis to survive and produce IFN-γ. They responded antigen independently and participated in protection from influenza virus. These metabolic dependencies may enable tuning of memory-like MAIT cell responses for vaccination and immunotherapies.
Endocrine and paracrine role of bile acids (2008)

Bile acids are not only important for the absorption of dietary lipids and fat soluble vitamins but are signalling molecules with diverse endocrine and paracrine functions. Bile acids regulate bile acid, lipid and glucose metabolism and modulate temperature and energy homeostasis. Furthermore, bile acids can not only promote cell proliferation and liver regeneration but can also induce programmed cell death. Bile acid functions are mediated through different pathways which comprise the activation of nuclear hormone receptors, of intracellular kinases and of the plasma membrane-bound, G-protein coupled bile acid receptor TGR5/Gpbar-1.
Prototype of early fire detection system for home monitoring based on Wireless Sensor Network (2017)

Fire is one of the few disasters that frequently occurred in Indonesia. Jakarta has archived 1139 fire incident with more than 20 casualties in 2016. By the rapid development of information technology and communication in Indonesia, it turns out that the number of incident and casualty still cannot be suppressed. This research is focused on early fire detection and home monitoring based on Wireless Sensor Network using 4 sensors such as temperature, air humidity, Carbon Monoxide, and smoke sensors. If the fire probability calculation categorized as high, system will perform an action of unlocking home door lock, turning on alarm, and notifying the user. Based on the trials and testing result, system is able to send notification to user precisely. However, error still can be encountered with up to 0.3% ratio on fire probability calculation.
Cover Feature: Ferroelectric Fractional‐Order Capacitors (ChemElectroChem 11/2017) (2017)

The Cover Feature demonstrates fractional-order capacitors: capacitance with no phase limitation; from theoretical modeling devices to real world products. More information can be found in the Article by A. Agambayev et al. on page 2807 in Issue 11, 2017
The Tinctorial Behaviour of Human Mast Cells (1954)

ABSTRACT Mast cells in the skin differentiate from perivascular fibroblasts. The cells nearest the walls of the blood-vessels contain mostly sparse and small mast granules; in those farther removed from the blood-vessels the granules are more numerous and coarse. With weak solutions of toluidine blue, mast granules reveal maximal chromotropy at pH 5·0. At lower pH values not all of the granules stain; at higher ones the granules and the intergranular cytoplasm stain progressively more orthochromatically. After digestion with ribonuclease and staining with toluidine blue buffered to pH 4·0 or 5·0 the mast granules are cherry red and all traces of orthochromatic staining are abolished; when stained at pH 6·0 or above, however, the cytoplasm and the granules attain a strong blue stain as if they had not been digested in the enzyme. Preparations fixed in Helly’s fluid may be washed in running water overnight and the mast granules show no diminution in chromotropy. The same sections may be stained, destained, and stained again at any desired pH with excellent results. Both the cytoplasm and the granules are Schiff-reactive, but the granules stain more intensely than the background. Sections stained with the periodic acid/Schiff technique and subsequently stained with toluidine blue reveal the mast granules brilliantly metachromatic, suggesting that the metachromatic and the Schiff-reactive substances, although co-existent, may be in fact separate elements. Mast granules, according to these tinctorial reactions, then, may contain 4 substances: (a) a protein cytoskeleton stainable with toluidine blue buffered to pH 6·0 or above; (b) some ribonucleic acid removable with ribonuclease and stainable with toluidine blue buffered to pH 5·0 or below; (c) an acid mucopolysaccharide which stains metachromatically ; and (d) a Schiff-reactive substance.
T helper 17 cells in Lyme disease and syphilis (2013)

T helper 17(Thl7)cells,a new subset of T cells capable of secreting interleukin-17(IL-17),play important roles in ost defense against microbial infection and mediation of immuno-inflammatory response.Lyme disease and secondary syphilis are chronic infectious diseases caused by different species of spirochaeta.Studies have shown that Th17 cells vary significantly with the stages of Lyme disease and syphilis in skin lesions,tissue fluid and peripheral blood of patients.It is believed that Thl7 cell activation is the main cause of arthritis in Lyme disease,and also responsible for the acute inflammation in secondary syphilis.

Key words: 
Syphilis; Interleukin-17; Lyme disease; Th17 cells
Epstein Barr virus-positive mucocutaneous ulcer of the colon associated Hodgkin lymphoma in Crohn’s disease (2015)

Epstein Barr virus (EBV) positive mucocutaneous ulcers (EBVMCU) form part of a spectrum of EBV-associated lymphoproliferative disease. They have been reported in the setting of immunosenescence and iatrogenic immunosuppression, affecting the oropharyngeal mucosa, skin and gastrointestinal tract (GIT). Case reports and series to date suggest a benign natural history responding to conservative management, particularly in the GIT. We report an unusual case of EBVMCU in the colon, arising in the setting of immunosuppression in the treatment of Crohn's disease, with progression to Hodgkin lymphoma 18 mo after cessation of infliximab. The patient presented with multiple areas of segmental colonic ulceration, histologically showing a polymorphous infiltrate with EBV positive Reed-Sternberg-like cells. A diagnosis of EBVMCU was made. The ulcers failed to regress upon cessation of infliximab and methotrexate for 18 mo. Following commencement of prednisolone for her Crohn's disease, the patient developed widespread Hodgkin lymphoma which ultimately presented as a life-threatening lower GIT bleed requiring emergency colectomy. This is the first report of progression of EBVMCU to Hodgkin lymphoma, in the setting of ongoing iatrogenic immunosuppression and inflammatory bowel disease.
Syntheses and Biological Activity of Neplanocin and Analogues (2008)

This chapter contains sections titled: Introduction New Methodologies in the Synthesis of Neplanocin A Modifications on Neplanocin A and Aristeromycin Conclusions References
The caveolin-binding motif of the pathogen-related yeast protein Pry1, a member of the CAP protein superfamily, is required for in vivo export of cholesteryl acetate (2014)

Proteins belonging to the CAP superfamily are present in all kingdoms of life and have been implicated in different physiological processes. Their molecular mode of action, however, is poorly understood. Saccharomyces cerevisiae expresses three members of this superfamily, pathogen-related yeast (Pry)1, -2, and -3. We have recently shown that Pry function is required for the secretion of cholesteryl acetate and that Pry proteins bind cholesterol and cholesteryl acetate, suggesting that CAP superfamily members may generally act to bind sterols or related small hydrophobic compounds. Here, we analyzed the mode of sterol binding by Pry1. Computational modeling indicates that ligand binding could occur through displacement of a relatively poorly conserved flexible loop, which in some CAP family members displays homology to the caveolin-binding motif. Point mutations within this motif abrogated export of cholesteryl acetate but did not affect binding of cholesterol. Mutations of residues located outside the caveolin-binding motif, or mutations in highly conserved putative catalytic residues had no effect on export of cholesteryl acetate or on lipid binding. These results indicate that the caveolin-binding motif of Pry1, and possibly of other CAP family members, is crucial for selective lipid binding and that lipid binding may occur through displacement of the loop containing this motif.
Pt@g-C3N4/CeO2 photocatalyst for the remediation of low concentration NO at room temperature (2020)

[email protected]3N4/CeO2 photocatalyst was prepared by calcination of g-C3N4/CeO2 mixture followed by impregnating Pt. Under the irradiation of visible light with the presence of water vapor at room temperature, [email protected]3N4/CeO2 showed significant performance for remediation of NOx. The deNOx mechanism was studied by modified in-situ FTIR. The results proved that NO was prone to adsorb on the surface of [email protected]2 and oxidized to nitrite for storage. Then, the photoinduced hydrogen on [email protected]3N4 component could diffuse into the vicinity of nitrite through the spillover effect of Pt and reacted with nitride to produce N2 and H2O.
Monoclonal antibodies that target the immunogenic proteins expressed in colorectal cancer (2014)

In an attempt to improve upon the end results obtained in treating colorectal cancer it was apparent that the earlier the diagnosis that could be obtained, the better the chance for obtaining desired results. In the case of more advanced tumors typified by later stage colorectal cancer, surgical debulking is an important part of the treatment strategy. Here the use of additional therapeutic modalities including chemotherapy and present day immunotherapy has failed to accomplish the desired improvements that have been sought after. Adjuvant therapy, has offered little to the overall survival. The concept of early detection is now recognized as the initial step in reaching proper end results and can readily be demonstrated from colorectal cancer studies. Here survival has been found to be a reflection of the stage at which the tumor is first identified and treated. When specific monoclonals targeting colorectal cancer are employed diagnostically, we have been able to demonstrate detection of colorectal cancer at its inception as a premalignant lesion, such that genotypic features can be identified before the phenotypic appearance of cancer can be noted.
Nanocavity-enabled Ultrafast Generation of Highly-indistinguishable Photons (2016)

Indistinguishable photon emission was investigated from a quantum dot-photonic crystal resonator system for the first time. This solid-state cavity quantum electrodynamical platform produced robust and high-fidelity generation of indistinguishable photons at unprecedented rates.
Effect of a Novel Series of Benzothiazolo‐Quinazolones on Epidermal Growth Factor Receptor (EGFR) and Biological Evaluations (2008)

A newly designed benzothiazolo-quinazolone series was synthesized by an aromatic amine and potassium thiocyanate in the presence of bromine in glacial acetic acid, and the final product was obtained by subsequent reaction with 5-arylamido/imidoalkyl-2-chlorobenzoic acid in the presence of potassium carbonate and further cyclization with sulphuric acid. A preliminary radiolabelling study with technetium shows a promising potential for further in vivo evaluation. Anti-bacterial, anti-viral and anti-tumor activities were evaluated for biological properties. Lead compounds are able to block epidermal growth factor receptor (EGFR) in human breast adenocarcinoma cell line, MCF-7.
Antiangiogenetische Therapie mit Bevacizumab vor Radioembolisation bei hepatisch metastasierten Mammakarzinomen: Einfluss auf die MAA-Szintigraphie, Bremsstrahlungs-SPECTund das Therapieansprechen (2020)

Ziel/Aim Bevacizumab (BEVA) wird bei metastasierten Mammakarzinomen (MAM) in der Erstlinientherapie angewandt. Bei hepatischer Metastasierung kann eine Radioembolisation (RE) durchgeführt werden. Eine antiangiogenetische Therapie könnte jedoch einen Einfluss auf die RE haben. In der vorliegenden Arbeit soll der Effekt von BEVA auf die 99mTc-MAA SPECT, Post-RE Bremsstrahlungs-SPECT (BS-SPECT), das Ansprechen und Toxizität untersucht werden.
Representing Procedural Knowledge for Semantic Networks using Neural Nets (1995)

We examined 108 uncemented femoral stems with modular femoral heads which had been retrieved for reasons other than loosening. There were detectable amounts of wear and corrosion in 10 of 29 (34.5%) mixed-alloy components and 7 of 79 (9%) single-alloy components after a mean implantation time of 25 months. We found no correlation between the presence or extent of corrosion or surface damage and any of time in situ, initial diagnosis, reason for removal, age, or weight. Stems with wear and corrosion were less likely to show histological bony ingrowth. The interface between the head and stem of modular total hip components is a possible source of ion release and wear debris, but wear and corrosion were totally absent in most specimens. This suggests that this problem could be avoided, and that further research is required to develop manufacturing methods which would minimise such changes.
Homoconjugated hydrogen bonds with amidine and guanidine bases Osmometric, potentiometric and FTIR studies (1997)

Five very strong N bases, 1,5-diazabicyclo[4.3.0]non-5-ene (DBN), pK a =23.4; 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU),pK a =23.9; tetramethylguanidine (TMG), pK a =23.3; 2-phenyl-tetramethylguanidine (PhTMG), pK a =20.6; and 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (MTBD), pK a =24.97; have been studied by osmometric measurements which showed that they are monomeric in acetonitrile solutions. The constants of the formation of homoconjugated complexes were determined by potentiometric measurements. In the IR spectra of the semi-protonated complexes of DBN, DBU and TMG, the homoconjugated N + –H···NN ···H– + N hydrogen bonds cause broad band complexes in the region 3200–2500 cm -1 instead of the expected continua. This spectral peculiarity is discussed.
Spectroscopic and Sensitometric Studies of Chemically Produced Silver Clusters (1996)

The reducing agents dimethylamineborane and SnCl2 were used to produce silver clusters chemically in an AgBr emulsion. These silver clusters were detected with diffuse reflectance spectroscopy at photographically relevant sensitizer concentrations, and their reflectance at 476 nm correlated well with the effects of these reducing agents on photographic sensitivity. Spectroscopy was used to monitor the photochemical reactions of these silver clusters. A portion of the 476-nm peak derived from the Kubelka&#x2013;Munk transform of the reflectance spectra could be photobleached using band-gap excitation, indicating that some of the silver clusters were destroyed by photogenerated holes. However, some silver clusters did not react with photoholes and these clusters may be electron-trapping. The decrease in peak height upon photobleaching indicated two distinct silver clusters in terms of their ease of bleaching by photoholes. A simple reaction model was found to be consistent with the concentration dependence of the peak height, suggesting that only one size of silver cluster is being produced under most of our reaction conditions.
Sol-gel transition in silica alkaline solutions. A NMR study (1994)

We carried on the NMR study of alkaline silica solutions and of their precipitates obtained under CaCl2 action. The mean degree of connectivity of the ionic precursors in solution is dependent on the silica and alkali concentrations. By CaCl2 action, two kinds of precipitates are obtained, the mean degree of connectivity of which may be related to their chemical analysis and to the molar ratio Rms = SiO2/K2O (or Na2O) of the mother solution. The effect of washing the precipitates with water was studied also.
Within striking distance: Task efficacy influences perceived size and distance (2010)

Past research has shown that a target was perceived to be smaller when the observer's effectiveness of dropping a dart on the target was reduced (Wesp et al., 2004). Additionally, perceived distance is overestimated when the physical effort required to traverse a distance is increased (Proffitt et al., 2003). In three experiments, we found that observers who performed a difficult throwing task perceived a target as smaller and the distance to the target as farther than observers that completed the same task under easier circumstances. Participants attempted to slide beanbags into targets at different distances and of different sizes under normal or difficult conditions. In the difficult condition, participants slid the beanbag with their non-dominant hand while their eyes were closed, and the easy condition allowed participants to slide the beanbags with their dominant hands and their eyes open. Afterwards, participants were blindfolded, and then tried to walk to the target or turned in the opposite direction of the target and tried to walk the distance to the target. Walking distances were significantly greater for participants who acted on the target under difficult conditions than those who acted on the target under normal circumstances. A visual matching task was performed to assess participants' perception of the target's width. Participants in the difficult condition gave smaller estimates for the target's width. These results suggest that the ease with which an observer acts on a target influences the perceived size, location, and distance of the target.
Фундаментальні аспекти прийняття рішень в системі інструментального забезпечення машинобудівних виробництв (2016)

Мета проекту – є розроблення наукових і методологічних основ оцінювання якості (технологічних властивостей) покупних різальних інструментів та прогнозування їх стану безпосередньо у процесі оброблення. У ході виконання науково-дослідної роботи на основі логіко-структурного аналізу та опрацювань статистичних даних щодо діяльності машинобудівних підприємств з дрібносерійним та одиничним типом виробництва та за допомогою встановлених принципів і методів формування баз даних створена система техніко-економічних показників якості металорізального інструменту, що купується, з урахуванням невизначеності інформації для конкретних виробничих умов машино-будівного підприємства.
Lincoln the Man (1931)

Journal Article Lincoln the Man. By Edgar Lee Masters. (New York : Dodd, Mead and Company, 1931. 520 pp. Illustrations. $5.00.) Get access M. M. Quaife M. M. Quaife Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 18, Issue 2, September 1931, Pages 260–262, https://doi.org/10.2307/1893397 Published: 01 September 1931
Ring cusp/hollow cathode discharge chamber performance studies (1988)

An experimental study was performed to determine the effects of hollow cathode position, anode position, and ring cusp magnetic field configuration and strength on discharge chamber performance. The results are presented in terms of comparative plasma ion energy cost, extracted ion fraction, and beam profile data. Such comparisons are used to demonstrate whether changes in performance are caused by changes in the loss rate of primary electrons to the anode or the loss rate of ions to discharge chamber walls or cathode and anode surfaces. Results show: (1) the rate of primary electron loss to the anode decreases as the anode is moved downstream of the ring cusp toward the screen grid; (2) the loss rate of ions to hollow cathode surfaces are excessive if the cathode is located upstream of a point of peak magnetic flux density at the discharge chamber centerline; and (3) the fraction of the ions produced that are lost to discharge chamber walls and ring magnet surfaces is reduced by positioning of the magnet rings so the plasma density is uniform over the grid surface, and adjusting their strength to a level where it is sufficient to prevent excessive ion losses by Bohm diffusion.
Clinical and diagnostic features of perioperative hypersensitivity to cefuroxime (2014)

All patients with confirmed hypersensitivity to cefuroxime reacted within 15 min of administration, but so did 65.5% of Cefuroxime negative patients, making timing of administration an unreliable predictor of causation in the perioperative setting. Provocations were always positive when carried out in skin test positive patients; however, eight patients had positive provocations only, highlighting the need for provocation in skin test negative patients.
Integrierte, planare Leckwellenantennen für 3D-Millimeterwellen-Radarsysteme basierend auf dem holografischen Prinzip (2014)

In dieser Arbeit werden Methoden vorgestellt, um die Abstrahlcharakteristik holografischer Antennen auf die Verwendung mit frequenzmodulierten Radarmodulen (FMCW-Prinzip) abzustimmen. Diese Kombination erlaubt durch die frequenzschwenkende Eigenschaft dieser Antennenart die gleichzeitige Distanz- und Winkelmessung zu Zielen im Raum. Der Fokus liegt auf dem Design der integrierbaren, holografischen Antennen und deren Optimierung hinsichtlich wichtiger Systemparameter.
Acquisition and Processing Challenges for Very Large Offset 3D VSP in the Arabian Gulf, Saudi Arabia (2011)

In 2009, Saudi Aramco acquired three large 3D VSP surveys in the Arabian Gulf, Saudi Arabia. These surveys were not only the first of their kind in Saudi Aramco, but each was also the largest, single well offshore 3D VSP worldwide. The primary objective of the survey was to improve the vertical and lateral resolution of signals from the sand stringers near and away from the well to properly place multi-lateral horizontal wells. A 100-level 3â€“component geophone tool was deployed in each well over a depth range of 1600 to 6600 feet. Each survey consisted of 32,000 shot points and 9 million traces. It was designed to optimize the subsurface coverage of mode-converted P-to-SV waves (C-waves) at the target using a maximum offset to depth ratio of 2.5. The surveys were completed in the shortest possible time to minimize drilling rig time. The objectives, acquisition design, QC procedures and logistical planning are described, which led to three successful offshore 3D VSPs.