gebhart/patrepeval huggingface dataset:
The presence of sboA and spaS genes and antimicrobial peptides subtilosin A and subtilin among Bacillus strains of the Amazon basin (2013)

This report demonstrates the usefulness of PCR for the genes spaS and sboA as a means of identifying Bacillus strains with a potential to produce subtilin and subtilosin A. One collection strain and five Bacillus spp. isolated from aquatic environments in the Amazon basin were screened by PCR using primers for sboA and spaS designed specifically for this study. The sequences of the PCR products showed elevated homology with previously described spaS and sboA genes. Antimicrobial peptides were isolated from culture supernatants and analyzed by mass spectrometry. For all samples, the mass spectra revealed clusters with peaks at m/z 3300-3500 Da, corresponding to subtilosin A, subtilin and isoforms of these peptides. These results suggest that the antimicrobial activity of these strains may be associated with the production of subtilosin A and/or subtilin. The PCR used here was efficient in identifying novel Bacillus strains with the essential genes for producing subtilosin A and subtilin.
Author Correction: Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion (2019)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Analysis of collagen fiber orientation in biological tissues using polarization-resolved second-harmonic-generation microscopy (2018)

Collagen plays an important role as a structural protein to determine the morphology and the mechanical property of tissues. Collagen orientation is one important parameter closely related with the mechanical property because collagen possesses fiber structure in tissues. However, it is difficult to evaluate the collagen fiber orientation quantitatively without invasiveness. In this article, we constructed continuously-polarization-resolved second-harmonic-generation (SHG) microscopy based on rapid polarization rotation every 15 degrees with electric-optic modulator, and applied it for the quantitative analysis of collagen fiber orientation. The orientation angle and degree of collagen fiber in different biological tissues were extracted from the curve fitting with a model function to a series of polarization-resolved
Histological Findings of a Local Adipofascial Flap That Was Implanted during Breast Conserving Surgery (2013)

We report a patient with breast cancer whose breast was immediately reconstructed using a local adipofascial flap and was then subsequently resected 3 years after the original surgical procedure due to local recurrence. In order to achieve local control of the solitary recurrent lesion, we resected the remnant breast, which gave us a useful opportunity to examine the previously implanted flap histologically. A 33-year-old Japanese female was diagnosed with T2N0M0 breast cancer in the outer area of her left breast and underwent partial mastectomy with immediate reconstruction using a local adipofascial flap. The breast lesion was considered to be invasive ductal carcinoma, scirrhous carcinoma, lymphatic invasion+, venous invasion-, estrogen receptor+, progesterone receptor+, and HER2/neu-. Involvement was noted in three of the twenty-five resected axillary lymph nodes. She received adjuvant hormone therapy, but developed a solitary local recurrence of the skin forty-five months after the initial procedure, for which she received total mastectomy, systemic chemotherapy, and hormone therapy. During the histological examination of the local adipofascial flap that had been implanted into the partial breast defect, normal fatty tissue and the implanted fascia were seen at the implantation site. This is a rare report in which a local flap that was implanted during oncoplastic breast surgery was histologically examined.
METABOLIC RESPONSE TO INTERVAL CYCLING USING 1H-MR SPECTRA OF HUMAN SKELETAL MUSCLE IN VIVO (1998)

722 The purpose of this study was to characterize metabolic changes in skeletal muscle following exercise between trained and untrained subjects using proton magnetic resonance spectroscopy (1H MRS). Fourteen healthy males (32± 5 yrs.) were grouped according to training history and maximum oxygen consumption (VO2max). The trained (n=7) and untrained (n=7) groups had an average VO2max of 5.36 ± 0.54 L/min and 3.48 ± 0.56 L/min, and percent body fat of 7.8 ± 2.9% and 18.8 ± 9.5%, respectively. The experimental trial consisted of 45 minutes of continuous cycle ergometry at workload intervals corresponding to 50% (3 min.) and 110% (2 min.) of the subject's ventilatory threshold. Pre and post-exercise spectrum localized to the vastus lateralis were acquired immediately before and after the exercise trial using a GE-SIGNA 1.5 Tesla whole body magnet (PRESS sequence with outer volume supression, TE 60 ms, TR 2,000 ms, 128 acquisitions). Pre and post-exercise peaks were evaluated at 3.2, 3.0, 1.5 and 1.3 ppm. A post-exercise peak resonating at 2.1 ppm was observed in all subjects regardless of fitness. In addition, the post-exercise peak remained elevated through 60 minutes of recovery. The metabolite responsible for the peak at 2.1 ppm has not been experimentally determined; however, it has been speculated to represent acetylcarnitine. Identification of the post-exercise peak at 2.1 ppm is a current research endeavor and will combine both 1-and 2-dimensional spectroscopy on excised muscle tissue.
Conference Scribe: turning conference calls into documents (2005)

Telephone calls and multi-party conference calls are transmitted and controlled by computer much like electronic documents. However, the way we traditionally use conference calls is very different from the way we use documents. This is primarily due to the transient unstructured nature of audio, and the lack of tools for managing, manipulating, and displaying telephone conversations and conference calls. This work is aimed at letting people use conference calls in many of the same ways that they use documents. This paper describes a system for turning conference calls into archived documents that can be browsed, skimmed, displayed, hyperlinked and annotated on the World Wide Web. The Conference Scribe system has three principle components: the SkimServer for recording and playback, the IDB Server for storing and retrieving time stamped labels, and a Java applet for interactively skimming recordings. The parallels between conference calls and documents are reviewed, and form the basis for the design of the system.
Market Access and National Treatment in China--Electronic Payment Services: An Illustration of the Structural and Interpretive Problems in GATS (2014)

The General Agreement on Trade in Services (GATS) has proved to be a less effective and more problematic instrument than hoped for at its enactment nearly twenty years ago. A recent case brought by the United States, China-Electronic Payment Services, illustrates a number of the problems, such as the uncertain definition and scope of sectors listed in Members' schedules of liberalization commitments. The Panel Report also shows the unique challenges of crafting a test and setting an evidentiary burden for establishing a state-driven monopoly when the industry has natural-monopoly characteristics-which are typical of many tradable services like telecommunications and payment processing networks. Further, this Panel was the first to deal with the complication of overlapping yet seemingly contradictory market access and national treatment commitments in a particular subsector. In this case, for electronic payment services, China appeared to commit to provide treatment no less favorable than that extended to domestic suppliers, yet at the same time reserved the right to deny foreign suppliers access to the Chinese market. Which inscription governs, given that GATS itself provides no clear rule for interpreting such a schedule? The Panel concluded that the denial of market access trumped the granting of national treatment, an outcome that may be reasonable in this particular context but which lacks a firm basis in the GATS text. This Comment argues that the confusion about scheduling of market access and national treatment commitments is symptomatic of deeper ambiguity about the scope of the disciplines themselves. This Comment explores of the implications of four different interpretive rules in eight different scheduling scenarios, extending the existing literature by more fully defining and evaluating the rules and applying them to a broader range of situations. Ultimately, no one rule can be consistent with the text of GATS and with the expectations of both the scheduling Member and its trading partners. To resolve this problem, this Comment advocates a pragmatic, empirical, harm- or surprise-minimizing approach aimed at approximating the common intention of Members. Finally, this Comment considers the lessons of China- Electronic Payment Services for the nascent negotiations on a new international trade in services agreement (TISA).
Recombinant human soluble tumor necrosis factor receptor fusion protein as treatment for steroid refractory graft‐versus‐host disease following allogeneic hematopoietic stem cell transplantation (2006)

Etanercept is a recombinant human soluble tumor necrosis factor (TNF-alpha) receptor fusion protein that inhibits TNF-alpha, a major mediator in the pathogenesis of graft-versus-host disease (GVHD). The purpose of our study was to evaluate the safety and efficacy of etanercept therapy in 21 patients with steroid-refractory acute GVHD (aGVHD) (n = 13) and chronic GVHD (cGVHD) (n = 8). Etanercept 25 mg was given subcutaneously twice weekly for 4 weeks followed by 25 mg weekly for 4 weeks. At the time of initiation of etanercept, 14 patients had skin, 13 had gastro-intestinal, 5 had liver, 5 had pulmonary, and 4 had oral involvement. Twelve patients (57%) completed 12 doses of therapy. Overall, 11 of 21 patients (52%) responded to the treatment with etanercept, including 6 patients (46%) with aGVHD [n = 4 complete response (CR), n = 2 partial response (PR)] and 5 patients (62%) with cGVHD (n = 1 CR, n = 4 PR). Clinical responses were most commonly seen in patients with refractory gut aGVHD with 55% of the patients having a CR and 9% having a PR. CMV reactivation occurred in 48% of patients, bacterial infections in 14% of patients, and fungal infections in 19% of patients. Fourteen patients (67%) were alive after a median follow-up of 429 days (range 71-1007 days) since initiation of etanercept. Seven patients died, 3 of infections, 2 of refractory aGVHD, and 2 of disease progression. In conclusion, our preliminary data indicate that etanercept is well tolerated and can induce a high response rate in patients with steroid-refractory aGVHD and cGVHD, particularly in the setting of GI involvement.
WetLab-2: Wet Lab RNA SmartCycler Providing PCR Capability on ISS (2015)

The WetLab-2 system will provide sample preparation and qRT-PCR analysis on-board the ISS, a capability to enable using the ISS as a real laboratory. The system will be validated on SpX-7, and is planned for its first PI use on SpX-9.
Cardiovascular events and safety outcomes associated with remdesivir using a World Health Organization international pharmacovigilance database (2021)

On October 2020, the US Food and Drug Administration (FDA) approved remdesivir as the first drug for the treatment of coronavirus disease 2019 (COVID-19), increasing remdesivir prescriptions worldwide. However, potential cardiovascular (CV) toxicities associated with remdesivir remain unknown. We aimed to characterize the CV adverse drug reactions (ADRs) associated with remdesivir using VigiBase, an individual case safety report database of the World Health Organization (WHO). Disproportionality analyses of CV-ADRs associated with remdesivir were performed using reported odds ratios and information components. We conducted in vitro experiments using cardiomyocytes derived from human pluripotent stem cell cardiomyocytes (hPSC-CMs) to confirm cardiotoxicity of remdesivir. To distinguish drug-induced CV-ADRs from COVID-19 effects, we restricted analyses to patients with COVID-19 and found that, after adjusting for multiple confounders, cardiac arrest (adjusted odds ratio [aOR]: 1.88, 95% confidence interval [CI]: 1.08-3.29), bradycardia (aOR: 2.09, 95% CI: 1.24-3.53), and hypotension (aOR: 1.67, 95% CI: 1.03-2.73) were associated with remdesivir. In vitro data demonstrated that remdesivir reduced the cell viability of hPSC-CMs in time- and dose-dependent manners. Physicians should be aware of potential CV consequences following remdesivir use and implement adequate CV monitoring to maintain a tolerable safety margin.
The Polish Crisis : Is there a way out? (1982)

Since World War II the Polish crisis has been the most open and prolonged social and political conflict in what is sometimes called real existing socialism. Debate in and between the international communist parties is sharp, particularly between the Communist Party o f Italy and the Soviet Communist Party. In this issue, ALR reprints part o f an article published in the January 1982 issue o f the British Communist Party's journal, Marxism Today. Written in November 1981, the article was overtaken by events. But parts o f its analysis bear reprinting even now. The portion o f the article ALR is reproducing deals with the need fo r a social and political evolution towards what the authors call an historic compromise. Before the imposition o f martial law, things appeared to be possibly moving in that direction. However, this undoubtedly difficult and complex process was cut short by the unfolding of the second of Johnstone and Westphal's three scenarios — a Polish army and police clamp down. The authors were among the very few who gave this possibility greater weight than direct Soviet intervention. Whether military rule can really help to resolve the deep-seated difficulties Poland faces is extremely doubtful. More likely, Poland (and ultimately the whole o f Eastern Europe) will have to eventually adopt some form o f Johnstone and Westphal's first scenario. Only then would the social and political situation in Poland be reflected in the present name of the Polish state — People's Poland.
Observation of1−0−Final States fromψ(2S)Decays ande+e−Annihilation (2005)

Using CLEO data collected from CESR e(+)e(-) collisions at the psi(2S) resonance and nearby continuum at sqrt[s]=3.67 GeV, we report the first significantly nonzero measurements of light vector-pseudoscalar hadron pair production (including rhopi, omegapi, rhoeta, and K(*0)K0 ) and the pi(+)pi(-)pi(0) final state, both from psi(2S) decays and direct e(+)e(-) annihilation.
Risk Factors for Glaucoma Drainage Device Revision or Removal Using the IRIS Registry (2022)

The size and scope of the IRIS Registry allows for detection of subtle associations between risk factors and GDD revision or removal surgery. The aforementioned demographic and clinical factors may all have an impact on GDD longevity and can inform the treatment options available for glaucoma patients.
Stability of a Class of Real-Time Switched Piezoelectric Shunts (2002)

Experimental and anecdotal evidences have shown that state-switched control strategies for piezoelectric actuators can be advantageous. However, most discussions of the stability of these systems has relied on heuristic, or physically motivated, arguments. In this paper, we show that recent open-circuit-short-circuit (OC-SC) state-switching control laws can be viewed as hybrid dynamical systems of Witsenhausen type. Within this framework, the closed-loop stability of OC/SC switching is rigorously established using the method of multiple Lyapunov functions.
Preparation and properties of cadmium telluride prepared by a three-step process (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and properties of cadmium telluride prepared by a three-step processShixing Weng and Michael CociveraCite this: Chem. Mater. 1993, 5, 10, 1577–1580Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/cm00034a031https://doi.org/10.1021/cm00034a031research-articleACS PublicationsRequest reuse permissionsArticle Views296Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Systemic pharmacological treatment of digital ulcers in systemic sclerosis: a systematic literature review (2023)

There are several systemic treatments, across four medication classes, that are effective therapies for the management of SSc DUs. However, a lack of robust data means it is not possible to define the optimal treatment regimen for SSc DUs. The relatively low quality of evidence available has highlighted further areas of research need.
Long-term viability of coronary artery smooth muscle cells on poly( l -lactide- co -ϵ-caprolactone) nanofibrous scaffold indicates its potential for blood vessel tissue engineering (2008)

Biodegradable polymer nanofibres have been extensively studied as cell culture scaffolds in tissue engineering. However, long-term in vitro studies of cell-nanofibre interactions were rarely reported and successful organ regeneration using tissue engineering techniques may take months (e.g. blood vessel tissue engineering). Understanding the long-term interaction between cells and nanofibrous scaffolds (NFS) is crucial in material selection, design and processing of the tissue engineering scaffolds. In this study, poly(L-lactide-co-epsilon-caprolactone) [P(LLA-CL)] (70:30) copolymer NFS were produced by electrospinning. Porcine coronary artery smooth muscle cells (PCASMCs) were seeded and cultured on the scaffold to evaluate cell-nanofibre interactions for up to 105 days. A favourable interaction between this scaffold and PCASMCs was demonstrated by cell viability assay, scanning electron microscopy, histological staining and extracellular matrix (ECM) secretion. Degradation behaviours of the scaffolds with or without PCASMC culture were determined by mechanical testing and gel permeation chromatography (GPC). The results showed that the PCASMCs attached and proliferated well on the P(LLA-CL) NFS. Large amount of ECM protein secretion was observed after 50 days of culture. Multilayers of aligned oriented PCASMCs were formed on the scaffold after two months of in vitro culture. In the degradation study, the PCASMCs were not shown to significantly increase the degradation rate of the scaffolds for up to 105 days of culture. The in vitro degradation time of the scaffold could be as long as eight months by extrapolating the results from GPC. These observations further supported the potential use of the P(LLA-CL) nanofibre in blood vessel tissue engineering.
Operation and analysis of a supercritical CO2 Brayton cycle. (2010)

Sandia National Laboratories is investigating advanced Brayton cycles using supercritical working fluids for use with solar, nuclear or fossil heat sources. The focus of this work has been on the supercritical CO{sub 2} cycle (S-CO2) which has the potential for high efficiency in the temperature range of interest for these heat sources, and is also very compact, with the potential for lower capital costs. The first step in the development of these advanced cycles was the construction of a small scale Brayton cycle loop, funded by the Laboratory Directed Research & Development program, to study the key issue of compression near the critical point of CO{sub 2}. This document outlines the design of the small scale loop, describes the major components, presents models of system performance, including losses, leakage, windage, compressor performance, and flow map predictions, and finally describes the experimental results that have been generated.
Residential electrical demand forecasting in very small scale: An evaluation of forecasting methods (2013)

Applications such as generator scheduling, household smart device scheduling, transmission line overload management and microgrid islanding autonomy all play key roles in the smart grid ecosystem. Management of these applications could benefit from short-term load prediction, which has been successfully achieved on large-scale systems such as national grids. However, the scale of the data for analysis is much smaller, similar to the load of a single transformer, making prediction difficult. This paper examines several prediction approaches for day and week ahead electrical load of a community of houses that are supplied by a common residential transformer, in particular: artificial neural networks; fuzzy logic; auto-regression; auto-regressive moving average; auto-regressive integrated moving average; and wavelet neural networks. In our evaluation, the methods use pre-recorded electrical load data with added weather information. Data is recorded from a smart-meter trial that took place during 2009-2010 in Ireland, which registered individual household consumption for 17 months. Two different scenarios are investigated, one with 90 houses, and another with 230 houses. Results for the two scenarios are compared and the performances of the evaluated prediction methods are discussed.
Curing of composite components by ultraviolet radiation: A review (2006)

Abstract Curing of polymer matrices by ultraviolet (UV) irradiation can be applied to a variety of processes in the production of composite components, as long as the component can be directly irradiated. Wet lay‐up techniques, vacuum infusion type processes with UV‐transparent membranes, filament winding, and prepreg processes have been adapted to UV curing. Unlike in thermal curing, the curing time is in the order of magnitude of minutes rather than hours, which means a significant reduction in cycle time. The radiation can be generated by a variety of sources suitable for various specific applications and different curing strategies. The most frequently used radiation sources are mercury arc lamps. Because of the absorption of radiation passing through matter, the thickness of laminates for efficient application of UV curing is limited. The curing mechanism is either radical polymerization for acrylate‐based resins or cationic polymerization for epoxies and vinyl ethers. The properties of the UV‐cured polymer matrix are determined by the cross‐linking density. This depends on the type and concentration of the photoinitiator and of the (optional) diluents, the intensity and the duration of the irradiation, and the temperature at which the curing process takes place. POLYM. COMPOS., 27:119–128, 2006. © 2006 Society of Plastics Engineers.