gebhart/patrepeval huggingface dataset:
The absence of the CD163 receptor has distinct temporal influences on intracerebral hemorrhage outcomes (2017)

Hemoglobin (Hb) toxicity precipitates secondary brain damage following intracerebral hemorrhage (ICH). CD163 is an anti-inflammatory Hb scavenger receptor and CD163-positive macrophages/microglia locally accumulate post-bleed, yet no studies have investigated the role of CD163 after ICH. ICH was induced in wildtype and CD163<sup>-/-</sup> mice and various anatomical and functional outcomes were assessed. At 3 d, CD163<sup>-/-</sup> mice have 43.4 ± 5.0% (p = 0.0002) and 34.8 ± 3.4% (p = 0.0003) less hematoma volume and tissue injury, respectively. Whereas, at 10 d, CD163<sup>-/-</sup> mice have 49.2 ± 15.0% larger lesions (p = 0.0385). An inflection point was identified, where CD163<sup>-/-</sup> mice perform better on neurobehavioral testing and have less mortality before 4 d, but increased mortality and worse function after 4 d (p = 0.0389). At 3 d, CD163<sup>-/-</sup> mice have less Hb, iron, and blood-brain barrier dysfunction, increased astrogliosis and neovascularization, and no change in heme oxygenase 1 (HO1) expression. At 10 d, CD163<sup>-/-</sup> mice have increased iron and VEGF immunoreactivity, but no significant change in HO1 or astrogliosis. These novel findings reveal that CD163 deficiency has distinct temporal influences following ICH, with early beneficial properties but delayed injurious effects. While it is unclear why CD163 deficiency is initially beneficial, the late injurious effects are consistent with the key anti-inflammatory role of CD163 in the recovery phase of tissue damage.
Poplar (2011)

Class evolution in object-oriented programming often causes so-called breaking changes, largely because of the rigidity of component interconnections in the form of explicit method calls and field accesses. We present a Java extension, Poplar, which we are currently developing. In Poplar, inter-component dependencies are expressed using declarative queries; concrete linking code, generated using a planning algorithm, replaces these at compile time. We show how Poplar can enable fully automatic integration of Java components through evolvable and statically checkable integration links, pointing the way to a new general composition method for object-oriented languages.
Atomic Layer Deposition of Cobalt Silicide Thin Films Studied by in Situ Infrared Spectroscopy (2015)

Atomic layer deposition of cobalt silicide (CoSi2) thin films on H-terminated Si(111) surfaces, using the cobalt-based precursor tertiarybutylallylcobalttricarbonyl (tBu-AllylCo(CO)3) and trisilane, is investigated by in situ Fourier transform infrared spectroscopy (FTIR) and ex situ X-ray photoelectron spectroscopy (XPS) to uncover the film growth mechanisms. The strong reactivity of tBu-AllylCo(CO)3 with H-terminated silicon surfaces and inertness with silicon oxide surfaces, as previously determined by IR spectroscopy [Chem. Mater. 2012, 24, 1025], opens the door for selective deposition. Deposition of CoSi2 is observed after a brief nucleation period (∼3 cycles), during which the stabilization of the cobalt precursor takes place, as evidenced by a shift of the stretch frequency of the carbonyl groups bonded to the Co center from 2010 to 1980 cm–1. This shift is evidence for completion of the catalytic reaction and leads to a surface termination and configuration that is favorable for subsequent ligand exchange with trisilane, fostering a classical ligand-exchange ALD growth. In steady state, the CoSi2 growth rate is 0.15 ± 0.05 Å per cycle, as measured by Rutherford backscattering spectroscopy (RBS). XPS measurements with depth profiling indicate that the CoSi2 film is stoichiometric with negligible carbon contamination.
Managing Identities Using Blockchains and CoSi (2016)

We combine collective signing and blockchains to create a secure and easy-to-use, decentralized SSH-key management system.
Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain‐like behaviour (2006)

Expression of the neuropeptide galanin is markedly up-regulated within the adult dorsal root ganglia (DRG) following peripheral nerve injury. We have previously demonstrated that galanin knockout (Gal-KO) mice have a developmental loss of a subset of DRG neurons. Galanin also plays a trophic role in the adult animal, and the rate of peripheral nerve regeneration and neurite outgrowth is reduced in adult Gal-KO mice. Here we describe the characterization of mice with an absence of GalR2 gene transcription (GalR2-MUT) and demonstrate that they have a 15% decrease in the number of calcitonin gene-related peptide (CGRP) expressing neuronal profiles in the adult DRG, associated with marked deficits in neuropathic and inflammatory pain behaviours. Adult GalR2-MUT animals also have a one third reduction in neurite outgrowth from cultured DRG neurons that cannot be rescued by either galanin or a high-affinity GalR2/3 agonist. Galanin activates extracellular signal-regulated kinase (ERK) and Akt in adult wild-type (WT) mouse DRG. Intact adult DRG from GalR2-MUT animals have lower levels of pERK and higher levels of pAkt than are found in WT controls. These data suggest that a lack of GalR2 activation in Gal-KO and GalR2-MUT animals is responsible for the observed developmental deficits in the DRG, and the decrease in neurite outgrowth in the adult.
Can idiosyncratic drug reactions occur in quick succession? a case of cross sensitivity between levetiracetam and phenytoin (2017)

The occurrence of adverse drug reactions (ADRs) to more than one drug in quick succession can cause diagnostic dilemma to the doctor and increased burden of suffering to the patient. We present a single case report of a 23 year old female who developed rash and agranulocytosis in quick succession as ADRs to phenytoin and levetiracetam respectively. These antiepileptic drugs (AEDs) were prescribed as prophylaxis against post traumatic seizures (PTS). Hence a proper rationale for the prophylactic treatment of PTS and pharmacovigilance for early detection of adverse drug reactions is the need of the hour.
Study of the effect of passivation layers on capacitance of AlGaN/GaN heterostructures (2016)

MOCVD grown AlGaN/GaN heterostructures on sapphire and silicon substrates have been studied. The capacity–voltage characteristic have been measured in the 200 Hz–1 MHz frequency range with a planar position of mercury and second probe on the specimen surface. The shape of the typical C–V curves for the heterostructures with upper undoped i-AlGaN and i-GaN layers 1,5–2,5 nm in thickness have been analyzed. The appearance of a typical peak on the C–V curves upon a change from the depletion region to the accumulation region has been registered in some structures with an i-GaN layer thickness of 5 nm and more at low frequencies (f<50–200 kHz). The height of this peak increased with a reduction of frequency. It has been found experimentally that the frequency at which the peak is registered can depend on the dislocation density in heterostructures. Possible explanation of the peak formation and band diagram transformation in these structures under an applied electric field have been presented. We show that the application of a Si3N4 passivation layer results in the formation of additional positive charge.
On the role of ventricular conduction time in rate stabilization for atrial fibrillation (2007)

Ventricular conduction time has limited effects on rate stabilization, which could be explained by multi-level interactions between antegrade waves induced by AF and retrograde waves induced by VP.
The human cytomegalovirus receptor on fibroblasts is a 30-kilodalton membrane protein (1990)

Previous studies have demonstrated that human cytomegalovirus (HCMV) binding to human foreskin fibroblasts (HFF) is mediated by a single type of molecule, likely a glycoprotein, which serves as a specific receptor for the virus. In the present experiments, HCMV was found to bind to an HFF membrane protein with an approximate molecular mass of 30 kilodaltons (kDa); weak binding to 28- and 92-kDa membrane components was also observed. Binding was specific, as it was inhibited by excess unlabeled HCMV. Radiolabeled HCMV also bound selectively to Raji and Daudi lymphoblastoid cell membrane proteins of the same molecular masses. The 30-kDa radiolabeled HFF membrane protein bound to HCMV in solution; this binding was also specific, as it was blocked by an excess of HCMV. These data suggest that a membrane protein with a molecular mass of approximately 30 kDa mediates HCMV binding to several cell types.
IgG1, IgG4 and IgE Antibody Reactivity to Mutant Forms of the Major Dust Mite Allergen Lep d 2 among Atopic and Nonatopic Subjects Naturally Exposed to <i>Lepidoglyphus destructor</i> (2001)

IgE/IgG4 Ab to rLep d 2 were restricted to atopic farmers and demonstrated parallel recognition patterns of conformational epitopes. In contrast, IgG1 antibodies are ubiquitously found and mainly recognize sequential structures. The observed isotypic difference and interindividual variation in antibody specificities among atopic and nonatopic subjects imply careful investigation of hypoallergenic variants destined for immunotherapy.
Tool-Use Model to Reproduce the Goal Situations Considering Relationship Among Tools, Objects, Actions and Effects Using Multimodal Deep Neural Networks (2021)

We propose a tool-use model that enables a robot to act toward a provided goal. It is important to consider features of the four factors; tools, objects actions, and effects at the same time because they are related to each other and one factor can influence the others. The tool-use model is constructed with deep neural networks (DNNs) using multimodal sensorimotor data; image, force, and joint angle information. To allow the robot to learn tool-use, we collect training data by controlling the robot to perform various object operations using several tools with multiple actions that leads different effects. Then the tool-use model is thereby trained and learns sensorimotor coordination and acquires relationships among tools, objects, actions and effects in its latent space. We can give the robot a task goal by providing an image showing the target placement and orientation of the object. Using the goal image with the tool-use model, the robot detects the features of tools and objects, and determines how to act to reproduce the target effects automatically. Then the robot generates actions adjusting to the real time situations even though the tools and objects are unknown and more complicated than trained ones.
Coagulation factor XII regulates inflammatory responses in human lungs (2017)

Increased procoagulant activity in the alveolar compartment and uncontrolled inflammation are hallmarks of the acute respiratory distress syndrome (ARDS). Here, we investigated whether the contact phase system of coagulation is activated and may regulate inflammatory responses in human lungs. Components of the contact phase system were characterized in bronchoalveolar lavage fluids (BALF) from 54 ARDS patients and 43 controls, and their impact on cytokine/chemokine expression in human precision cut lung slices (PCLS) was assessed by a PCR array. Activation of the contact system, associated with high levels of coagulation factor XIIa (Hageman factor, FXIIa), plasma kallikrein and bradykinin, occurred rapidly in ARDS lungs after the onset of the disease and virtually normalized within one week from time of diagnosis. FXII levels in BALF were higher in ARDS non-survivors than survivors and were positively correlated with tumor necrosis factor (TNF)-α concentration. FXII induced the production and release of interleukin (IL)-8, IL-1β, IL-6, leukemia inhibitory factor (LIF), CXCL5 and TNF-α in human PCLS in a kallikrein-kinin-independent manner. In conclusion, accumulation of FXII in ARDS lungs may contribute to the release of pro-inflammatory mediators and is associated with clinical outcome. FXII inhibition may thus offer a novel and promising therapeutic approach to antagonize overwhelming inflammatory responses in ARDS lungs without interfering with vital haemostasis.
Repair of Cranial Nerves During Intracranial Neurosurgery (1998)

Advances in various fields of neuroscience have led to a more aggressive surgical attitude toward skull base lesions. Consequently, cranial nerves are more frequently damaged, causing significant morbidity. This article discusses the theoretical and practical aspects of intracranial nerve repair, including histologic aspects of cranial nerve repair, types of coaptation technique, and recovery of function. Results of various studies show that intracranial nerve repair is worthwhile and that at least some functional recovery occurs, mainly dependent on the preoperative function and the complexity of the cranial nerve involved.
Introduction to XML (2006)

This chapter contains sections titled: Markup and Elements Attributes XML Declaration Namespaces Well-Formedness and Validity XML Schema Summary
Exploiting the Complexity of Elastic Waves in the Earth (2005)

Wave propagation in the Earth often leads to complex waveforms that are highly repeatable. We present examples of coda wave interferometry; a technique to monitor changes in the Earth from changes in recorded waveforms.
Organocatalytic stereoselective cyanosilylation of small ketones (2022)

Enzymatic stereoselectivity has typically been unrivalled by most chemical catalysts, especially in the conversion of small substrates. According to the 'lock-and-key theory'<sup>1,2</sup>, enzymes have confined active sites to accommodate their specific reacting substrates, a feature that is typically absent from chemical catalysts. An interesting case in this context is the formation of cyanohydrins from ketones and HCN, as this reaction can be catalysed by various classes of catalysts, including biological, inorganic and organic ones<sup>3-7</sup>. We now report the development of broadly applicable confined organocatalysts for the highly enantioselective cyanosilylation of aromatic and aliphatic ketones, including the challenging 2-butanone. The selectivity (98:2 enantiomeric ratio (e.r.)) obtained towards its pharmaceutically relevant product is unmatched by any other catalyst class, including engineered biocatalysts. Our results indicate that confined chemical catalysts can be designed that are as selective as enzymes in converting small, unbiased substrates, while still providing a broad scope.
Morton (Z) scan based real-time variable resolution CMOS image sensor (2005)

An image sensor architecture with an alternative image scan method, based on Morton (Z) order, is presented. This scan, compared to the conventional row scan, enables faster and efficient average computation of square image blocks. Digital averaging is used and the pixel data is read out with either the original resolution, a 2 /spl times/ 2 or a 4 /spl times/ 4 block averaging. A test chip of 128 /spl times/ 128 array has been implemented in 0.35-/spl mu/m CMOS technology, has 15% fill factor, is operated by a 3.3-V supply and dissipates 30 mW at video rate.
Evaluation of a 40- to 125-μm Ge:Sb photoconductor array for airborne astronomy (2003)

Testing of a 40 to 125 &mu;m Ge:Sb photoconductor array for AIRES (Airborne Infra-Red Echelle Spectrometer) is described. The prototype array is a 2&times;24 module which can be close-stacked with other modules to provide larger two-dimensional formats. Collecting cones on a 0.08 inch pitch concentrate incident radiation into integrating cavities containing the detectors. The array is read out by two Raytheon SBRC 190 cryogenic multiplexers that also provide a CTIA (capacitive transimpedance amplifier) unit cell for each detector. We have conducted a series of tests to evaluate the array dark current, responsivity and detective quantum efficiency.
[<sup>99m</sup>Tc(CO)<sub>3</sub>]<sup>+</sup> and [<sup>99m</sup>TcO<sub>2</sub>]<sup>+</sup> Radiolabeled Cyclic Melanotropin Peptides for Melanoma SPECT Imaging (2014)

The melanoma targeting peptides (Ala-triazol)Ac-Re(Arg(11))CCMSH and N4-CO-Re(Arg(11))CCMSH were radiolabeled with [(99m)Tc(CO)3](+) and [(99m)TcO2](+), respectively, and examined for in vitro cell binding, in vivo biodistribution and imaging properties. The (Ala-triazol)Ac-Re(Arg(11))CCMSH and N4-CO-Re(Arg(11))CCMSH were synthesized as protected peptides on resin followed by rhenium cyclization with [(C6H5)3P]2ReOCl3 in DMF. The peptides were labeled with (99m)Tc and examined for radiochemical stability and melanoma cell binding. In vivo biodistribution and SPECT/CT imaging studies were performed in B16/F1 melanoma tumor bearing C57 mice. (99m)Tc(CO)3-(Ala-Triazol)Ac- Re(Arg(11))CCMSH and (99m)TcO2-N4-CO-Re(Arg(11))CCMSH were stable and internalized in B16/F1 melanoma cells upon binding. In vivo biodistribution studies revealed that tumor uptake of (99m)Tc(CO)3-(Ala-Triazol)Ac-Re(Arg(11))CCMSH was 6.08±1.06% ID/g and 7.05±1.48% ID/g at 2 h and 4 h post injection, respectively. Tumor uptake of (99m)TcO2-N4-CORe(Arg(11))CCMSH was 7.54±1.82% ID/g and 2.28±0.22% ID/g at 1 h and 2 h post injection, respectively. SPECT/CT imaging studies showed that tumor selective uptake of the radiolabeled peptides, which was confirmed by competitive blocking studies.
Modulation of B‐cell tolerance by Murine Gammaherpesvirus 68 infection: requirement for Orf73 viral gene expression and follicular helper T cells (2013)

Viruses such as Epstein-Barr virus (EBV) have been linked to mechanisms that support autoantibody production in diseases such as systemic lupus erythematosus. However, the mechanisms by which viruses contribute to autoantibody production remain poorly defined. This stems in part, from the high level of seropositivity for EBV (> 95%) and the exquisite species specificity of EBV. In this study we overcame these problems by using murine gammaherpesvirus 68 (MHV68), a virus genetically and biologically related to EBV. We first showed that MHV68 drives autoantibody production by promoting a loss of B-cell anergy. We next showed that MHV68 infection resulted in the expansion of follicular helper T (Tfh) cells in vivo, and that these Tfh cells supported autoantibody production and a loss of B-cell anergy. Finally, we showed that the expansion of Tfh cells and autoantibody production was dependent on the establishment of viral latency and expression of a functional viral gene called Orf73. Collectively, our studies highlighted an unexpected role for viral latency in the development of autoantibodies following MHV68 infection and suggest that virus-induced expansion of Tfh cells probably plays a key role in the loss of B-cell anergy.
Immunosuppressant exposure confounds gene expression analysis in systemic lupus erythematosus (2022)

Medications have significant effect on gene module expression in SLE patients. These findings emphasize the need to control for medications in studies of gene expression in SLE.
Amplification and overexpression of the erbB-2 gene in human tumors: its involvement in tumor development, significance as a prognostic factor, and potential as a target for cancer therapy. (1993)

The erbB-2 gene is amplified in a high percentage of human adenocarcinomas arising at numerous sites including breast, ovaries, lung, stomach and salivary gland. Gene amplification leads to overexpression of the protein, a member of the receptor tyrosine kinase family. A number of clinical studies have attempted to correlate the presence of high erbB-2 protein levels in tumors with poor patient prognosis. The majority of the studies do show a positive correlation suggesting that erbB-2 gene amplification and overexpression are signs of more aggressive tumors. The elevated levels of the erbB-2 protein, its extracellular accessibility, and its involvement in the malignant process make it an excellent candidate for tumor specific therapeutic agents.
Regioselective modification of unprotected glycosides (2015)

The regioselective modification of unprotected glycosides represents shortcuts in carbohydrate chemistry and enables efficient routes to complex derivatives.
Objective cough frequency in Idiopathic Pulmonary Fibrosis (2010)

This study confirms objectively that cough is a major, very distressing and disabling symptom in IPF patients. The strong correlations between objective cough counts and cough related quality of life measures suggest that in IPF patient's, perception of cough frequency is very accurate.
High power 980 nm laser diode for free space communications at high bitrates (2002)

Direct intensity modulation at 3 Gb/s is demonstrated with a 980 nm semiconductor laser diode, which is mainly designed for EDFA pumping applications at high power and reliability. Implications of operating conditions on system performance are addressed.
Completion Selection Methodology for Optimum Reservoir Performance andProject Economics in Deepwater Applications (1999)

Completion Selection Methodology for Optimum Reservoir Performance and Project Economics in Deepwater Applications R.J. Wetzel, Jr.; R.J. Wetzel, Jr. Baker Oil Tools Search for other works by this author on: This Site Google Scholar Steve Mathis; Steve Mathis Baker Oil Tools Search for other works by this author on: This Site Google Scholar Gene Ratterman; Gene Ratterman Baker Oil Tools Search for other works by this author on: This Site Google Scholar Randall Cade Randall Cade Baker Hughes Inteq Search for other works by this author on: This Site Google Scholar Paper presented at the SPE Annual Technical Conference and Exhibition, Houston, Texas, October 1999. Paper Number: SPE-56716-MS https://doi.org/10.2118/56716-MS Published: October 03 1999 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Get Permissions Search Site Citation Wetzel, R.J., Mathis, Steve, Ratterman, Gene, and Randall Cade. "Completion Selection Methodology for Optimum Reservoir Performance and Project Economics in Deepwater Applications." Paper presented at the SPE Annual Technical Conference and Exhibition, Houston, Texas, October 1999. doi: https://doi.org/10.2118/56716-MS Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll ProceedingsSociety of Petroleum Engineers (SPE)SPE Annual Technical Conference and Exhibition Search Advanced Search This paper was prepared for presentation at the 1999 SPE Annual Technical Conference and Exhibition held in Houston, Texas, 3–6 October 1999. Keywords: project economics, completion installation and operations, completion, application, spe annual technical conference, sand control, completion option, productivity, deepwater, directional drilling Subjects: Drilling Operations, Hydraulic Fracturing, Directional drilling, Completion Installation and Operations, Sand Control This content is only available via PDF. 1999. Society of Petroleum Engineers You can access this article if you purchase or spend a download.
Supplementary Data from Myeloablative Haploidentical Transplantation Is Superior to Chemotherapy for Patients with Intermediate-risk Acute Myelogenous Leukemia in First Complete Remission (2023)

&lt;p&gt;Figure S1-S3. Table S1-S3&lt;/p&gt;
Intentions in Communication. (1992)

Journal Article Book Reviews Get access Intentions in Communication. Edited By Philip R. Cohen, Jerry Morgan and Martha E. Pollack. (London: MIT Press, 1990. Pp. x + 508. Price £40.50.) Ken Turner Ken Turner Brighton Polytechnic Search for other works by this author on: Oxford Academic Google Scholar The Philosophical Quarterly, Volume 42, Issue 167, April 1992, Pages 245–247, https://doi.org/10.2307/2220222 Published: 01 April 1992