gebhart/patrepeval huggingface dataset:
An obstacle avoidance algorithm for mobile robot: the improved weighted safety vector field method (2002)

An obstacle avoidance algorithm, the weighted safety vector field (WSVF) method, is presented. In determining the orientation of the mobile robot, the algorithm first computes the primary steering angle for normal manuevering which is derived based on the fuzzy inference rule. To cope with the constrained environments such as corner and hallway, the algorithm then computes the secondary steering angle which is derived based on the fuzzy inference rule. The primary steering angle is used for the normal manuevering whereas the secondary steering angle compensates for the wiggling motion of the mobile robot that occurs frequently at the corner or at the hallway. The presented algorithm has been successfully tested on the simulation example.
Liquid Quinones for Solvent‐Free Redox Flow Batteries (2017)

Liquid benzoquinone and naphthoquinone having diethylene glycol monomethyl ether groups are designed and synthesized as redox active materials that dissolve supporting electrolytes. The Li-ion batteries based on the liquid quinones using LiBF<sub>4</sub> /PC show good performance in terms of voltage, capacity, energy efficiency, and cyclability in both static and flow modes. A battery is constructed without using intentionally added organic solvent, and its high energy density (264 W h L<sup>-1</sup> ) demonstrates the potential of solvent-free organic redox flow batteries using liquid active materials.
A Tripartite Complex HIV-1 Tat-Cyclophilin A-Capsid Protein Enables Tat Encapsidation That Is Required for HIV-1 Infectivity (2023)

The viral transactivating protein Tat has been shown to stimulate several steps of HIV gene expression. It was found to facilitate reverse transcription.
An Evaluation of the Vestigial Signal Defense for Civil GPS Anti-Spoofing (2018)

A receiver-autonomous non-cryptographic civil GPS antispoofing&#13;\ntechnique called the vestigial signal defense&#13;\n(VSD) is defined and evaluated. This technique monitors&#13;\ndistortions in the complex correlation domain to detect&#13;\nspoofing attacks. Multipath and spoofing interference&#13;\nmodels are developed to illustrate the challenge of distinguishing the two phenomena in the VSD. A campaign to&#13;\ncollect spoofing and multipath data is described, which&#13;\nspecific candidate VSD techniques can be tested against.&#13;\nTest results indicate that the presence of multipath complicated&#13;\nthe setting of an appropriate spoofing detection&#13;\nthreshold.
Topological insulator vertically-emitting laser array (2021)

We present the first experimental demonstration of a topological insulator VCSEL array. Our laser consists of 30 emitters, emitting in a single frequency, displaying interference proving that the emitters act as a single laser.
OnabotulinumtoxinA Treatment of Mild Glabellar Lines in Repose (2010)

OnabotulinumtoxinA has demonstrated the ability to eliminate mild glabellar lines at repose for a significant number of patients. This effect, albeit more subtle than the effect on dynamic or more severe glabellar lines, may be an important treatment goal for patients who seek a smoother appearance at repose.
ChemInform Abstract: CYCLIZATION OF QUINONYLMETHANE DYES AND ANALOGOUS MEROCYANINES. 4. DIHYDROANTHRACENOPHENAZINONES (1976)

Abstract Das Chinon (II) wird in DMF oder Acetonitril mit den Perchloraten der Chinoxaline (I) zu den entsprechenden Chinonylmethanfarbstoffen umgesetzt, deren Ringschluß zu den Titelverbindungen (III) in Pyridin/ Eisessig bei Temperaturen bis zu 70°C vorgenommen wird.
Action of CAP on the malT promoter in vitro (1983)

DNase I footprinting experiments demonstrated that CAP, the cyclic AMP receptor protein of Escherichia coli, binds around position -70 at the promoter of malT, the positive regulator gene of the maltose regulon. The binding of CAP in the presence of cyclic AMP favored the subsequent specific binding of RNA polymerase. Initiation of malT transcription in vitro displayed an absolute requirement for CAP at all tested RNA polymerase concentrations. However this was not the case with a mutant promoter (malTp1), which leads to CAP-independent malT expression in vivo. In that case an effect of CAP was seen only at the lower concentrations of RNA polymerase. These results, which suggest that CAP stimulates malT expression by promoting the binding of polymerase to the promoter, are compared with those obtained in other systems.
Current concepts in tumour-derived organoids (2020)

Cancer comprises a collection of highly proliferative and heterogeneous cells growing within an adaptive and evolving tumour microenvironment. Cancer survival rates have significantly improved following decades of cancer research. However, many experimental and preclinical studies do not translate to the bedside, reflecting the challenges of modelling the complexities and multicellular basis of human disease. Organoids are novel, complex, three-dimensional ex vivo tissue cultures that are derived from embryonic stem cells, induced pluripotent stem cells or tissue-resident progenitor cells, and represent a near-physiological model for studying cancer. Organoids develop by self-organisation, and can accurately represent the diverse genetic, cellular and pathophysiological hallmarks of cancer. In addition, co-culture methods and the ability to genetically manipulate these organoids have widened their utility in cancer research. Organoids thus offer a new and exciting platform for studying cancer and directing personalised therapies. This review aims to highlight how organoids are shaping the future of cancer research.
Bismuth-rich bimetallic clusters (CuBi8)3+ and [MBi10]4+ (M = Pd, Pt) from ionothermal synthesis (2021)

Abstract The reaction of Bi, BiBr 3 , and CuBr in the Lewis-acidic ionic liquid [BMIm]Br·4AlBr 3 (BMIm = 1- n -butyl-3-limidazolium) at 180 °C yielded air-sensitive, shiny black crystals of (CuBi 8 )[AlBr 4 ] 2 [Al 2 Br 7 ]. Crystals of [ M Bi 10 ][AlCl 4 ] 4 ( M = Pd, Pt) were obtained by reacting Bi, BiCl 3 , and M Cl 2 under similar conditions. The structures have been determined by X-ray diffraction on single-crystals and were found to be very similar to that of the known analogues with other halogens, although not isostructural. In crystals of the complex salts, polyhedral bimetallic clusters (CuBi 8 ) 3+ or [ M Bi 10 ] 4+ are embedded in matrices of halogenidoaluminate anions. The heteroatomic nido -cluster (CuBi 8 ) 3+ consists of a (Bi 8 ) 2+ square antiprism η 4 -coordinating a copper(I) cation. In the cluster cation [ M Bi 10 ] 4+ , the metal atoms M center a pentagonal antiprism of bismuth atoms.
RNA interference-mediated knockdown of CD49e (alpha5 integrin chain) in human thymic epithelial cells modulates the expression of multiple genes and decreases thymocyte adhesion. (2010)

International audience
Supplementary Table from Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma (2023)

Supplementary Table from Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma
VLSI Implementation of Fast Connected Component Labeling Using Finite State Machine Based Cell Network (2008)

Connected component labeling of a binary image is an indispensable task for image segmentation and analysis. For real time video object segmentation, total processing time to label all the objects of an entire image is critical as it is constrained by inter frame temporal difference. Parallel dedicated hardware is necessary to solve this problem in real time. In this paper we have proposed a parallel VLSI architecture for fast connected component labeling of a binary video frame image. We have adopted a seeded region-growing algorithm, which is implemented in a state machine based cell network. The design is verified in XILINX FPGA with real time video image data containing different objects with different shapes and sizes. The worst-case labeling time for a full video frame is 5 ms (using a 32 MHz clock), which is well below the required inter frame timing interval of 40 ms.
A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa (2022)

Proteases play a major role in many vital physiological processes. Trypsin-like serine proteases (TLPs), in particular, are paramount in proteolytic cascade systems such as blood coagulation and complement activation. The structural topology of TLPs is highly conserved, with the trypsin fold comprising two β-barrels connected by a number of variable surface-exposed loops that provide a surprising capacity for functional diversity and substrate specificity. To expand our understanding of the roles these loops play in substrate and co-factor interactions, we employ a systematic methodology akin to the natural truncations and insertions observed through evolution of TLPs. The approach explores a larger deletion space than classical random or directed mutagenesis. Using FVIIa as a model system, deletions of 1-7 amino acids through the surface exposed 170 loop, a vital allosteric regulator, was introduced. All variants were extensively evaluated by established functional assays and computational loop modelling with Rosetta. The approach revealed detailed structural and functional insights recapitulation and expanding on the main findings in relation to 170 loop functions elucidated over several decades using more cumbersome crystallization and single deletion/mutation methodologies. The larger deletion space was key in capturing the most active variant, which unexpectedly had a six-amino acid truncation. This variant would have remained undiscovered if only 2-3 deletions were considered, supporting the usefulness of the methodology in general protease engineering approaches. Our findings shed further light on the complex role that surface-exposed loops play in TLP function and supports the important role of loop length in the regulation and fine-tunning of enzymatic function throughout evolution.
Systems toxicology meta-analysis—From aerosol exposure to nanotoxicology (2019)

Systems toxicology marks an important stage in the evolution of toxicology. It combines the insights from traditional toxicology end points, high-throughput data, and quantitative analysis of large cause-and-effect molecular network models that provide the most mechanistic information in the interpretation of high-throughput data. Here, we show an example on how pulmonary causal biological network models can be used in a meta-analysis of independent studies on engineered nanomaterials to gain mechanistic insight into the similarities and differences of the ways the engineered nanomaterials impact biological processes in the mouse lung. Meta-analyses using the lung network models could be used in various toxicological applications to find underlying trends in response to exposures, derive compound-specific mechanistic signatures, and translate between species.
Alkamides and phenethyl derivatives from Aristolochia gehrtii (2001)

From the stems of Aristolochia gehrtii, the cis-N-feruloyl-3-O-methyldopamine and a hemiacetal derivative of 5-hydroxymethylfurfural were isolated, together with twenty-two known compounds. These compounds include five lignans, three terpenes, six alkaloids (five alkamides), two benzoic acid derivatives, and six phenethyl derivatives. The structures of the isolated compounds were determined by means of spectroscopic methods and comparison with literature data.
Serological markers predict inflammatory bowel disease years before the diagnosis (2012)

A panel of serological markers is able to predict development of CD and UC in individuals from a low-risk population.
An Automatic Measurement of Formaldehyde in Air by a Monitoring Tape Method. (1998)

ホルムアルデヒドを連続して測定できる自動モニターを開発した. 既報のホルムアルデヒドテープを用いて, ホルムアルデヒドを通気する時間を延長しても, ゼロガスでのバックグラウンド値が上昇するため0.1ppmのホルムアルデヒドを検出することが困難であった. 従来のヒドロキシルアミン硫酸塩とpH指示薬を用いた発色系はそのままとし, 吸着剤であるシリカゲルを混和したテープを検討した. このテープにホルムアルデヒドをテープ表面に吹き付ける方法に変えることで, ゼロガスでのバックグラソド値の上昇が抑えられ, 30分間の測定でホルムアルデヒド0.08ppmを検出することができた. ガスの流量100mL/min, ガスの導入時間30分間の場合, ホルムアルデヒドの濃度が0.1ppmのときの再現性は, 標準パーセントで表すと3.8%(n=10)であった. 本モニターの連続測定については, 20時間にわたって指示値は±10%以内と安定していた. ホルムアルデヒド以外にアセトアルデヒドには応答を示したが, それ以外のトルエン, キシレン, ベンゼン等のVOCには全く応答を示さなかった.
Synergy between Tannerella forsythia and Fusobacterium nucleatum in biofilm formation (2004)

During dental plaque formation, the interaction of different organisms is important in the development of complex communities. Fusobacterium nucleatum is considered a 'bridge-organism' that facilitates colonization of other bacteria by coaggregation-mediated mechanisms and possibly by making the environment conducive for oxygen intolerant anaerobes. These studies were carried out to determine whether coaggregation between F. nucleatum and Tannerella forsythia is important in the formation of mixed species biofilms. Further, the role of BspA protein, a surface adhesin of T. forsythia, in coaggregation and biofilm formation was investigated. The results showed the development of synergistic mixed biofilms of F. nucleatum and T. forsythia when these bacteria were cocultured. The BspA protein was not involved in biofilm formation. Though BspA plays a role in coaggregation with F. nucleatum, presumably other adhesins are also involved. The synergistic biofilm formation between the two species was dependent on cell-cell contact and soluble components of the bacteria were not required. This study demonstrates that there is a positive synergy between F. nucleatum and T. forsythia in the development of mixed biofilms and that the cell-cell interaction is essential for this phenomenon.
Radar Instrument Calibration of TerraSAR-X (2008)

TerraSAR-X is a high resolution synthetic aperture radar (SAR) satellite launched in 2007. Its active phased array X-Band antenna hosts 384 transmit/receive modules (TRMs) controlling the beam steering in azimuth and eleva-tion. A calibration network provides monitoring of internal instrument behaviour by introducing additional calibration pulses. Evaluation of calibration pulses for every image acquisition guarantees high radiometric stability of all SAR products. This paper shows the latest in-orbit results of the radar instrument stability and TRM performance. The novel PN Gating method is verified in a spaceborne environment for the first time ever.
Importance of over‐reading ambulatory ECG‐based microvolt T‐wave alternans to eliminate three main sources of measurement error (2019)

Relying only on automated MMA-TWA values obtained during ambulatory ECG monitoring can lead to incorrect measurement of TWA. Our findings offer the potential to reduce false-positive TWA results and to achieve more accurate detection of true repolarization alternans.
Solvent Assisted Bonding of Polymethylmethacrylate: Characterization Using the Response Surface Methodology (2008)

Abstract: This work presents the investigation of a solvent assisted bonding process developed for the fabrication of closed micro channels made from polymethylmethacrylate (PMMA). The effects of four processing parameters on the deformation and the bond strength of the micro channel have been investigated using the response surface methodology (RSM). High bond strengths (3.5 ± 0.8 MPa) at low deformations (1.6 ± 0.3 %) have been achieved at the center point of the design of experiment.
Influence of Freezing-and-Thawing Damage on Behavior of Reinforced Concrete Elements (2007)

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[Feasibility of using hepatitis B virus surface antigen as target antigen in immunogen therapy against cancer]. (2002)

DC-HBsAg induces HBsAg-specific antitumor effect, stronger than that induced by recombinant HBsAg vaccine although the humoral immune response elicited by DC vaccine is much weaker that that induced by recombinant HBsAg vaccine. HBsAg can be used as a target antigen in immunogen therapy for treatment of cancer.
Characterization of Mineral Targets by Laser Desorption and Ionization in Preparation of the MOMA Investigation Onboard the ExoMars-2018 Rover (2016)

International audience
Security at Physical Layer in NOMA Relaying Networks With Cooperative Jamming (2022)

In this letter, we consider a non-orthogonal multiple access (NOMA) network with a half-duplex (HD) decode-and-forward (DF) relay to improve physical layer security (PLS) of two users. Two legitimate users of U1 and U2 are far from the multi-antenna base station (BS). Thus, a relay with multi-antenna is used to enhance communication and obtain diversity gain. In the first stage, the BS transmits the superimposed signal to the relay via NOMA. Meanwhile, U1 generates the jamming signal to the eavesdropper (Eve). In the second stage, the relay forwards the signal to two users while the BS transmits the jamming signal to disrupt the eavesdropping. It is assumed that the Eve has strong eavesdropping ability. Thus, we need to introduce jamming to guarantee security. Furthermore, we use U1 instead of a full-duplex (FD) relay to send the jamming signal in the first stage to avoid self-interference. To measure the secrecy performance, a closed-form expression of secrecy outage probability (SOP) is derived for the two users. Simulation results are provided to verify the correctness of the proposed scheme.
Level of control of hypertension in Mexican Americans and non-Hispanic whites. (1993)

Compared with non-Hispanic whites, Mexican Americans have a higher prevalence of diabetes, greater adiposity, and an unfavorable body fat distribution. The prevalence of hypertension, however, is similar or lower in Mexican Americans than in non-Hispanic whites. There is little information on the level of blood pressure control in Mexican Americans. We compared the mean blood pressure levels of Mexican American and non-Hispanic white hypertensive subjects in the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Hypertension was defined as one or more of a systolic blood pressure > or = 160 mm Hg, a diastolic blood pressure > or = 95 mm Hg, and current use of antihypertensive medications. Three hundred and fifty-eight Mexican Americans and 241 non-Hispanic whites met these criteria. Poor hypertension control was defined as a systolic blood pressure > or = 160, a diastolic blood pressure > or = 95 mm Hg, or both. After adjustment for age, gender, obesity, body fat distribution, and level of educational attainment, Mexican American hypertensive subjects were in significantly poorer control than non-Hispanic white hypertensive subjects. The reasons for their poorer control are unknown, but our findings emphasize the importance of hypertension in this ethnic group.
Power‐based, phase‐informed selection of single nucleotide polymorphisms for disease association screens (2006)

Single nucleotide polymorphisms (SNPs) are becoming widely used as genotypic markers in genetic association studies of common, complex human diseases. For such association screens, a crucial part of study design is determining what SNPs to prioritize for genotyping. We present a novel power-based algorithm to select a subset of tag SNPs for genotyping from a map of available SNPs. Blocks of markers in strong linkage disequilibrium (LD) are identified, and SNPs are selected to represent each block such that power to detect disease association with an underlying disease allele in LD with block members is preserved; all markers outside of blocks are also included in the tagging subset. A key, novel element of this method is that it incorporates information about the phase of LD observed among marker pairs to retain markers likely to be in coupling phase with an underlying disease locus, thus increasing power compared to a phase-blind approach. Power calculations illustrate important issues regarding LD phase and make clear the advantages of our approach to SNP selection. We apply our algorithm to genotype data from the International HapMap Consortium and demonstrate that considerable reduction in SNP genotyping may be attained while retaining much of the available power for a disease association screen. We also demonstrate that these tag SNPs effectively represent underlying variants not included in the LD analysis and SNP selection, by using leave-one-out tests to show that most (approximately 90%) of the "untyped" variants lying in blocks are in coupling-phase LD with a tag SNP. Additional performance tests using the HapMap ENCyclopedia of DNA Elements (ENCODE) regions show that the method compares well with the popular r2 bin tagging method. This work is a concrete example of how empirical LD phase may be used to benefit study design.
Enhancer of Zeste Homolog 2 Inhibition Attenuates Renal Fibrosis by Maintaining Smad7 and Phosphatase and Tensin Homolog Expression (2015)

Enhancer of zeste homolog 2 (EZH2) is a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types. However, the role of EZH2 in renal fibrogenesis remains unexplored. In this study, we found high expression of EZH2 and H3K27me3 in cultured renal fibroblasts and fibrotic kidneys from mice with unilateral ureteral obstruction and humans with CKD. Pharmacologic inhibition of EZH2 with 3-deazaneplanocin A (3-DZNeP) or GSK126 or siRNA-mediated silencing of EZH2 inhibited serum- and TGFβ1-induced activation of renal interstitial fibroblasts in vitro, and 3-DZNeP administration abrogated deposition of extracellular matrix proteins and expression of α-smooth muscle actin in the obstructed kidney. Injury to the kidney enhanced Smad7 degradation, Smad3 phosphorylation, and TGFβ receptor 1 expression, and 3-DZNeP administration prevented these effects. 3-DZNeP also suppressed phosphorylation of the renal EGF and PDGFβ receptors and downstream signaling molecules signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2 after injury. Moreover, EZH2 inhibition increased the expression of phosphatase and tensin homolog (PTEN), a protein previously associated with dephosphorylation of tyrosine kinase receptors in the injured kidney and serum-stimulated renal interstitial fibroblasts. Finally, blocking PTEN with SF1670 largely diminished the inhibitory effect of 3-DZNeP on renal myofibroblast activation. These results uncovered the important role of EZH2 in mediating the development of renal fibrosis by downregulating expression of Smad7 and PTEN, thus activating profibrotic signaling pathways. Targeted inhibition of EZH2, therefore, could be a novel therapy for treating CKD.
FAR INFRARED SPECTROSCOPY OF ANISTROPIC CRYSTALS. (1967)

Author Institution: King's College Strand
A comparison of sender-initiated and receiver-initiated reliable multicast protocols (1994)

Sender-initiated reliable multicast protocols, based on the use of positive acknowledgments (ACKs), lead to an ACK implosion problem at the sender as the number of receivers increases. Briefly, the ACK implosion problem refers to the significant overhead incurred by the sending host due to the processing of ACKs from each receiver. A potential solution to this problem is to shift the burden of providing reliable data transfer to the receivers—thus resulting in a receiver-initiated multicast error control protocol based on the use of negative acknowledgments (NAKs). In this paper we determine the maximum throughputs of the sending and receiving hosts for generic sender-initiated and receiver-initiated protocols. We show that the receiver-initiated error control protocols provide substantially higher throughputs than their sender-initiated counterparts. We further demonstrate that the introduction of random delays prior to generating NAKs coupled with the multicasting of NAKs to all receivers has the potential for an additional substantial increase in the throughput of receiver-initiated error control protocols over sender-initiated protocols.