gebhart/patrepeval huggingface dataset:
K-ELITISTISK SELEKTION FÖR DISTRIBUERADE GENETISKA ALGORITMER (2015)

Genetiska algoritmer(GA)är en sökalgoritm som framlades av Holland (1975). GA efterliknar evolution; en mängd lösningar kombineras och muterar under loppet av flera generationer för att skapa en så bra lösning som möjligt. En vidareutveckling av GA är distribuerade genetiska algoritmer (DGA); en samling GA exekverar isolerat från varandra och med jämna mellanrum delar lösningarmed varandra. Detta arbete har undersökt hur DGA påverkas av k-elitism; att de k bästa lösningarna kopieras till nästa generation utan att förändras. En DGA har implementerats som löser handelsresandeproblem från problembiblioteket TSPLIB. Experimenten visade att k-elitism påverkar hur bra lösningar som produceras samt hur många generationer som krävs innan algoritmen slutar göra framsteg. Vissa värden på k gav i regel bättre resultat, och andra värden på k gav i regel sämre resultat. Det föreslås att mer forskning görs på området. Resultaten bör verifieras för andra variabeluppsättningar och migrationsfrekvensens betydelse bör undersökas djupare.
Feedback-Based Deterministic Optimization Is a Robust Approach for Supply Chain Management under Demand Uncertainty (2022)

Optimization-based inventory and supply chain management (SCM) under uncertainty can provide organizations a significant competitive advantage. Implementing optimization under uncertainty using stochastic or robust formulations requires accurate characterization of uncertain parameters (e.g., customer demand, production and transportation lead times) and can be computationally demanding. On the other hand, online deterministic optimization addresses uncertainty via a periodic recalculation of SCM decisions based on feedback of updated system information. In this work, we carry out an extensive comparative numerical study to analyze and contrast the performance of online and offline algorithms for several deterministic and uncertainty-aware inventory production and distribution planning formulations under uncertain customer demand in the context of multiechelon, multiperiod supply chains. We demonstrate empirically that using online deterministic optimization rooted in feedback control has significant computational and economic performance advantages over stochastic and robust optimization formulations.
Endogenous Parathyroid Hormone Response to Thyrocalcitonin-Induced Hypocalcemia in the Cow (1971)

Journal Article Endogenous Parathyroid Hormone Response to Thyrocalcitonin-Induced Hypocalcemia in the Cow Get access RICHARD E. REITZ, RICHARD E. REITZ *Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, and the Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania New Bolton Center, Kennett Square, Pennsylvania Search for other works by this author on: Oxford Academic Google Scholar G. P. MAYER, G. P. MAYER *Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, and the Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania New Bolton Center, Kennett Square, Pennsylvania Search for other works by this author on: Oxford Academic Google Scholar LEONARD J. DEFTOS, LEONARD J. DEFTOS *Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, and the Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania New Bolton Center, Kennett Square, Pennsylvania Search for other works by this author on: Oxford Academic Google Scholar JOHN T. POTTS, JR. JOHN T. POTTS, JR. *Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, and the Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania New Bolton Center, Kennett Square, Pennsylvania Search for other works by this author on: Oxford Academic Google Scholar Endocrinology, Volume 89, Issue 3, 1 September 1971, Pages 932–935, https://doi.org/10.1210/endo-89-3-932 Published: 01 September 1971 Article history Received: 23 November 1970 Published: 01 September 1971
Coadministration of Melatonin and Insulin Improves Diabetes-Induced Impairment of Rat Kidney Function (2021)

The coadministration of exogenous melatonin and insulin abolished many of the deleterious effects of type 1 diabetes on rat renal function.
ES-WSN: Energy Efficient by Switching between Roles of Nodes in WSNs (2015)

The objective of our work is to propose a new approach called ES-WSN (Energy Efficiency by Switching between roles in WSNs) for the efficient use of energy in wireless sensor networks (WSN). Our solution ES-WSN extends the lifetime of the nodes in the network and guarantees a fair evolution of their level of energy. This is based on the exchanging of roles between relays and sensors nodes based on their positioning and deployment in the WSN. This process is provided according to two parameters from the communication environment. The first one is the distance between the sensors and relays nodes. The second one is the remaining energy of nodes in the network. After evaluation, ES-WSN has achieved better performance compared to two other solutions proposed in the literature.
Risk Factors Associated With Progression Toward Endocrine Insufficiency in Chronic Pancreatitis (2019)

We observed a measurable decline in β-cell function and glycemic control in patients with CP. Patients with a history of tobacco smoking, surgical drainage, or pancreatic calcification may be at highest risk.
The combination of mesoglycan and VEGF promotes skin wound repair by enhancing the activation of endothelial cells and fibroblasts and their cross-talk (2022)

Skin wound healing requires accurate therapeutic topical managements to accelerate tissue regeneration. Here, for the first time, we found that the association mesoglycan/VEGF has a strong pro-healing activity. In detail, this combination induces angiogenesis in human endothelial cells promoting in turn fibroblasts recruitment. These ones acquire a notable ability to invade the matrigel coating and to secrete an active form of metalloproteinase 2 in presence of endothelial cells treated with mesoglycan/VEGF. Next, by creating intrascapular lesions on the back of C57Bl6 mice, we observed that the topical treatments with the mesoglycan/VEGF promotes the closure of wounds more than the single substances beside the control represented by a saline solution. As revealed by eosin/hematoxylin staining of mice skin biopsies, treatment with the combination mesoglycan/VEGF allows the formation of a well-structured matrix with a significant number of new vessels. Immunofluorescence analyses have revealed the presence of endothelial cells at the closed region of wounds, as evaluated by CD31, VE-cadherin and fibronectin staining and of activated fibroblasts assessed by vimentin, col1A and FAP1α. These results encourage defining the association mesoglycan/VEGF to activate endothelial and fibroblast cell components in skin wound healing promoting the creation of new vessels and the deposition of granulation tissue.
Salmonella T3SS effector SseK1 arginine-glycosylates the two-component response regulator OmpR to alter bile salt resistance (2023)

Type III secretion system (T3SS) effector proteins are primarily recognized for binding host proteins to subvert host immune response during infection. Besides their known host target proteins, several T3SS effectors also interact with endogenous bacterial proteins. Here we demonstrate that the Salmonella T3SS effector glycosyltransferase SseK1 glycosylates the bacterial two-component response regulator OmpR on two arginine residues, R15 and R122. Arg-glycosylation of OmpR results in reduced expression of ompF, a major outer membrane porin gene. Glycosylated OmpR has reduced affinity to the ompF promoter region, as compared to the unglycosylated form of OmpR. Additionally, the Salmonella ΔsseK1 mutant strain had higher bile salt resistance and increased capacity to form biofilms, as compared to WT Salmonella, thus linking OmpR glycosylation to several important aspects of bacterial physiology.
Encapsulation of bimodal metal powders as a tool to manage the properties of hierarchically organized structures (2020)

Encapsulation of bimodal powders based on nano- and microparticles of 316L, Ti-6Al-4V, Ti-Al and 90W-6Ni-4Fe alloys by organic ligands result in the formation of a lyophilic layer on the particle surface, reduction of powder agglomeration and spontaneous formation of hierarchically organized close-packed structures. The behavior of encapsulated hierarchical micro/nanostructures based on bimodal alloy powders when sintering was investigated. Encapsulation of 316L, Ti-6Al-4V and 90W-6Ni-4Fe alloys powders leads to an increase in the initial density of compacted powders and an increase in the relative density of sintered samples compared to untreated powders. On the contrary, encapsulation of Ti-Al alloy powder tends to reduce both the initial density and the density of the samples sintered at 1200°C. The sintering behavior of samples is influenced by both the chemical structure of the encapsulating agent and the chemical composition of the alloy particles.
3D Vision-Based Local Path Planning System of a Humanoid Robot for Obstacle Avoidance (2013)

This paper addresses the vision based local path planning system for obstacle avoidance. To handle the obstacles which exist beyond the field of view (FOV), we propose a Panoramic Environment Map (PEM) using the MDGHM-SIFT algorithm. Moreover, we propose a Complexity Measure (CM) and Fuzzy logic-based Avoidance Motion Selection (FAMS) system to enable a humanoid robot to automatically decide its own direction and walking motion when avoiding an obstacle. The CM provides automation in deciding the direction of avoidance, whereas the FAMS system chooses the avoidance path and walking motion, based on environment conditions such as the size of the obstacle and the available space around it. The proposed system was applied to a humanoid robot that we designed. The results of the experiment show that the proposed method can be effectively applied to decide the avoidance direction and the walking motion of a humanoid robot.
Observations of the Locomotor Responses of Diabrotica Virgifera lec., D. Undecimpunctata Howardi Barber and D. Longicornis (SAY), as Induced by Various Odoriferous Plant Materials (1964)

Three species of Diabrotica, the western corn rootworm, D. Virgifera, Lec; the northern corn rootworm, D. longicornis, (say); and the southern corn rootworm, D. undecimpuenctata howardi, Barber; are generally abundant during the summer months in corn fields in various areas throughout the Midwest. Field observations indicate that these insects apparently have preferred feeding sites on host plants. In corn fields they frequently congregate and feed on the silks and tassels. As the corn reached maturity, the Diabrotica beetles feed extensively on the more succulent parts of the remaining silks. Some feeding also occurs on weeds and other plants within the corn field. Feeding occurs on the blossoms and leaves of alfalfa and clover and on the blossoms of cucurbits. The field observations previously mentioned provided the basis for the preliminary investigation onto the olfactory capabilities of the Diabrotica beetles. The ultimate objective of this type of research, although not within the scope of this problem, is to isolate and identify the compound or compounds responsible for attraction. This material might ultimately be incorporated with an insecticide in trapping devices to reduce the general practice of widespread field application chemicals.
Advancement in liquid exfoliation of graphite through simultaneously oxidizing and ultrasonicating (2014)

Simultaneously oxidizing and ultrasonicating graphite for 60 min can create high-structural integrity yet solution-processable graphene for a great many applications.
In Vivo Assembly of Yeast Mitochondrial α-Ketoglutarate Dehydrogenase Complex (1991)

The assembly of alpha-ketoglutarate dehydrogenase complex (KGDC) has been studied in wild-type Saccharomyces cerevisiae and in respiratory-deficient strains (pet) with mutations in KGD1 and KGD2, the structural genes for alpha-ketoglutarate dehydrogenase (KE1) and dihydrolipoyl transsuccinylase (KE2) components, respectively. Mutants unable to express KE1 or KE2 form partial complexes similar to those reported in earlier studies on the resolution and reconstitution of bacterial and mammalian KGDC. Thus mutants lacking KE1 assemble a high-molecular-weight subcomplex consisting of a KE2 core particle with bound dihydrolipoyl dehydrogenase (E3). Similarly, mitochondrial extracts of mutants lacking KE2 contain dimeric KE1 and E3. These components, however, are not associated with each other. The partial complexes detected in the mutants are capable of reconstituting normal KGDC when supplied with the missing subunit. Complete restoration of overall alpha-ketoglutarate dehydrogenase activity is achieved by mixing appropriate ratios of mitochondrial extracts from mutants deficient in KE1 and KE2. The reconstitution of enzymatic activity correlates with binding of KE1 to the KE2-E3 particle to form a complex with the same sedimentation properties as wild-type KGDC. Overexpression of KE2 relative to KE1 results in a preponderance of incompletely assembled complexes with substoichiometric contents of KE1. Formation of a complex with a full complement of KE1 therefore depends on a balanced output of KE1 and KE2 from their respective genes. Biochemical screens of a pet mutant collection have led to the identification of a new gene required for the expression of enzymatically active KGDC. Mitochondria of the mutant have all of the catalytic subunits of KGDC. Sedimentation analysis of these components indicates that while the mutant has a stable KE2-E3 subcomplex, the interaction of KE1 with KE2 core is much weaker in the mutant than in the wild type. The gene product responsible for this phenotype, therefore, appears to function at a late stage of assembly of KGDC, most likely by posttranslational modification of one of the subunits.
A study on data and information integration for conveyancing, cadastre and land registry automation (2016)

Land is immovable, thus, the transfer of landed property from a seller to a buyer and registration thereof involves conveying pertinent data and information between private and public sector agencies, firms, and institutions. Conveyancing processes, cadastres and land registers are intended to provide clarity with respect to legal rights and privileges associated with landed properties. Incorrect conveyancing data or incomplete information in the cadastre and registry can undermine legal rights as well as compromise security relating to landed property. Modern era information and communications technology systems feature capabilities like capturing, recording, storage, retrieval and transmission of data. These capabilities can facilitate data and information integration and interconnectivity necessary to align conveyancing processes to both the cadastre and registry. It is in this context that this paper qualitatively discusses business issues for the application of information and communications technologies towards the automation of property transactions and land administration systems.
Human immunodeficiency virus-associated wasting and mechanisms of cachexia associated with inflammation. (1998)

Profound weight loss and progressive depletion of muscle mass is a common sequela of chronic diseases such as cancer, tuberculosis, and human immunodeficiency virus (HIV) infection. Studies of HIV-associated wasting have revealed several possible mechanisms. Alterations in anabolic hormones, energy intake, energy expenditure, and production of proinflammatory cytokines, which cause cachexia, may contribute to wasting in HIV-infected patients. These studies have revealed the complexity of the interactions between cytokines and the hormones that typically regulate catabolic-anabolic homeostasis. Despite this complexity, HIV-associated wasting should be manageable. Several strategies are currently under investigation, including anabolic steroid and human growth hormone therapy, appetite stimulants, nutritional supplementation, and cytokine antagonists. Some of these approaches have shown early promise. Further research in these areas should facilitate development of effective intervention strategies and lead to improvements in quality of life for patients suffering from wasting syndromes.
Miniaturized Terrestrial Walking Robot Using PVDF/PVP/PSSA Based Ionic Polymer–Metal Composite Actuator (2015)

This paper presents a design and fabrication of millimeter scale walking robot using ionic polymer–metal composite (IPMC) actuator as the robot's leg for walking in terrestrial environment. A small scale of new IPMC actuator based on poly-vinylidene fluoride (PVDF)/polyvinyl pyrrolidone (PVP)/polystyrene sulfuric acid (PSSA) blend membrane was fabricated and employed in this study to sustain and drive the walking robot with sufficient force and displacement. The PVDF/PVP/PSSA based IPMC actuator with a polymer mixture ratio of 15/30/55 shows improved performances than Nafion based IPMC actuator. To enhance a traction force of the walking robot and to increase the life time of IPMC actuators, the IPMC strips are covered with a thin PDMS (polydimethylsiloxane) layer. A miniaturized terrestrial walking robot (size: 18 × 11 × 12 mm, weight: 1.3 g) with a light weight robot's body which can support 2-, 4-, or 6-IPMC-leg models was designed and implemented the walking motion on the ground at the maximum speed of 0.58 mm/s.
GTP and IAP Shifts Adenosine A1-Agonist Binding in Smooth Muscle Membranes to the Low Affinity State, Similar to the one Found in Intact Cells (1991)

Abstract Adenosine A1 receptors in the smooth muscle cell line DDT1 MF-2 were characterized by radioligand binding using the antagonist [3H]-8-cyclopentyl-1,3-dipropylxanthine ([3H]DPCPX) as the ligand. Binding properties of adenosine agonists and antagonists to both intact cells and membranes were investigated.
Ab initio study toward designing transition-state analogues which elicit proteolytic catalytic antibodies (2000)

New haptens useful for eliciting proteolytic antibodies are proposed. Transition state conformations of the amide and ester bond cleavages of simple quantum models were obtained by HF/6–31G* ab initio calculations. The results suggested that in our model of the transition state, forming the tetrahedral structure at the carbonyl carbon in a nucleophilic addition step is sufficient for ester bond cleavage, while formation of both the tetrahedral structure and the appropriate orientation of the lone-pair electrons on the nitrogen for the proton addition is necessary for amide bond cleavage. The key feature for designing good and/or potent haptens deduced from the transition state model could therefore be that both the tetrahedral conformation at the carbonyl carbon and proper orientation of lone pairs are simultaneously and appropriately reproduced in the haptens. Based on calculations, we designed potentially appropriate new haptens with the phosphonamidate functional group for eliciting proteolytic antibodies. Copyright ­© 2000 John Wiley & Sons, Ltd.
A systematic review of the diagnostic test accuracy of brief cognitive tests to detect amnestic mild cognitive impairment (2016)

Several brief cognitive tests have shown promising diagnostic test accuracy results for identifying aMCI. However, concerns over the quality of the constituent studies and lack of evidence on the predictive validity of these tests mean that new validation studies are warranted. Copyright © 2016 John Wiley & Sons, Ltd.
Reverberation time versus volume for active acoustic systems (2016)

If two rooms have the same reverberation time but different cubic volumes, then they will differ in acoustic strength. Many authors have presented recommendations for reverberation time as a function of volume for different purposes. There are many parameters that, if held constant, yield different reverberation times for different cubic volumes: strength, clarity, critical distance, etc. For example, the ITU-R BS.1116 recommendation for reverberation time versus volume corresponds to rooms of constant average absorption per square meter. This paper will review the literature on reverberation time versus volume, show the connection between STI and reverberation versus volume, and propose a recommendation for reverberation versus volume for active acoustic systems.
Dysphagia in Parkinson’s disease: a therapeutic challenge? (2010)

This article focuses on the current status and research directions on swallowing disorders (dysphagia) in patients with Parkinson's disease (PD). Although epidemiological data are scarce, increased incidence of dysphagia in patients with PD leads to increased risk of mortality, secondary to aspiration pneumonia. Although studies show that aspiration pneumonia is a common cause of death in this group of patients, clinical practice lacks an evidence base and there is an increased need for randomized clinical trials. Importantly, the underlying mechanisms accounting for the progression of dysphagia in PD are still unclear. Furthermore, evidence shows that dopaminergic medication does not affect swallowing performance. Future research in the field is urgently needed and may result in improved management of dysphagia in patients with PD.
BLOCK DIAGRAM COMPUTER SIMULATION OF ANALYTICAL INSTRUMENTS (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBLOCK DIAGRAM COMPUTER SIMULATION OF ANALYTICAL INSTRUMENTSEdward VoigtmanCite this: Anal. Chem. 1993, 65, 23, 1029A–1035APublication Date (Print):December 1, 1993Publication History Published online31 May 2012Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/ac00071a715https://doi.org/10.1021/ac00071a715research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts