gebhart/patrepeval huggingface dataset:
Approximate dispersion relations for qP – qSV -waves in transversely isotropic media (2000)

Abstract To decouple qP and qSV sheets of the slowness surface of a transversely isotropic (TI) medium, a sequence of rational approximations to the solution of the dispersion relation of a TI medium is introduced. Originally conceived to allow isotropic P-wave processing schemes to be generalized to encompass the case of qP-waves in transverse isotropy, the sequence of approximations was found to be applicable to qSV-wave processing as well, although a higher order of approximation is necessary for qSV-waves than for qP-waves to yield the same accuracy. The zeroth-order approximation, about which all other approximations are taken, is that of elliptical TI, which contains the correct values of slowness and its derivative along and perpendicular to the medium's axis of symmetry. Successive orders of approximation yield the correct values of successive orders of derivatives in these directions, thereby forcing the approximation into increasingly better fit at the intervening oblique angles. Practically, the first-order approximation for qP-wave propagation and the second-order approximation for qSV-wave propagation yield sufficiently accurate results for the typical transverse isotropy found in geological settings. After only slight modification to existing programs, the rational approximation allows for ray tracing, (f-k) domain migration, and split-step Fourier migration in TI media—with little more difficulty than that encountered presently with such algorithms in isotropic media.
Elimination of intermetallic compound interferences in twin-electrode thin-layer anodic stripping voltammetry (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElimination of intermetallic compound interferences in twin-electrode thin-layer anodic stripping voltammetryDaryl A. Roston, Elwood E. Brooks, and William R. HeinemanCite this: Anal. Chem. 1979, 51, 11, 1728–1732Publication Date (Print):September 1, 1979Publication History Published online1 May 2002Published inissue 1 September 1979https://pubs.acs.org/doi/10.1021/ac50047a033https://doi.org/10.1021/ac50047a033research-articleACS PublicationsRequest reuse permissionsArticle Views172Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Evaluation of HPLC for the Screening and Quantitation of Benzodiazepines and Acetaminophen in Post Mortem Blood* (1983)

High performance liquid chromatographic (HPLC) methods have been developed for the analysis of benzodiazepines, some of their metabolites and for acetaminophen in post mortem blood. The methods include a single-step extraction and the use of internal standards for quantitation. Two different columns, mu-Bondapack C18 and mu-Bondapak phenyl with two different mobile phases are described. The methods presented are sensitive, reproducible, relatively selective, and have been used regularly in forensic toxicological analysis.
Chirality Organization of Ferrocenes Bearing Podand Dipeptide Chains:  Synthesis and Structural Characterization (2000)

A variety of ferrocenes bearing podand dipeptide chains have been synthesized to form an ordered structure in both solid and solution states and have been investigated by 1H NMR, FT-IR, CD, and X-ray crystallographic analyses. Conformational enantiomerization through chirality organization was achieved by the intramolecular hydrogen bondings between the podand dipeptide chains. The single-crystal X-ray structure determination of the ferrocene 2 bearing the podand dipeptide chains (-D-Ala-D-Pro-OEt) revealed two C2-symmetric intramolecular hydrogen bondings between CO (Ala) and NH (another Ala) of each podand dipeptide chain to induce the chirality-organized structure. The molecular structures of the ferrocene 1 composed of the podand L-dipeptide chains (-L-Ala-L-Pro-OEt) and 2 are in a good mirror image relationship, indicating that they are conformational enantiomers. An opposite helically ordered molecular arrangement was formed in the crystal packing of 2 as compared with 1. The ferrocene 2 exhibited induced circular dichroism (CD), which appeared at the absorbance of the ferrocene moiety. The mirror image of the CD signals between 1 and 2 was observed, suggesting that the chirality-organized structure via intramolecular hydrogen bondings is present even in solution. The ferrocene 4 bearing the podand dipeptide chains (-Gly-L-Leu-OEt) also showed an ordered structure in the crystal based on two intramolecular hydrogen bondings between CO (Gly) and NH (another Gly) of each podand dipeptide chain, together with intermolecular hydrogen bondings between CO adjacent to the ferrocene unit and NH (neighboring Leu) to create the highly organized self-assembly. A different self-assembly was observed in the crystal of the ferrocene 5 composed of the podand dipeptide chains (-Gly-L-Phe-OEt), wherein each molecule is bonded to two neighboring molecules through two pairs of symmetrical intermolecular hydrogen bonds to form a 14-membered intermolecularly hydrogen-bonded ring. These ordered structures based on the intramolecular hydrogen bondings in the solution state are also confirmed by 1H NMR and FT-IR.
Implementation of Advanced Methods for Reproductive Pharmacovigilance in Autism: A Meta-Analysis of the Effects of Prenatal Antidepressant Exposure (2020)

In this meta-analysis, neither psychiatric control nor discordant-sibling designs supported an association between prenatal antidepressant exposure and autism. Discordant-sibling designs effectively addressed surveillance bias in pharmacovigilance reports derived from national registries and other large databases.
[Cytomegalovirus retinitis in children with AIDS acquired through materno-fetal transmission]. (1995)

CMV retinitis in vertically transmitted AIDS can occur early in childhood and must be checked systematically in the patients with low CD 4 count because of the usual asymptomatic onset.
Design and Optimization of Ram Air–Based Thermal Management Systems for Hybrid-Electric Aircraft (2020)

Ram air–based thermal management systems (TMS) are investigated herein for the cooling of future hybrid-electric aircraft. The developed TMS model consists of all components required to estimate the impacts of mass, drag, and fuel burn on the aircraft, including heat exchangers, coldplates, ducts, pumps, and fans. To gain a better understanding of the TMS, one- and multi-dimensional system sensitivity analyses were conducted. The observations were used to aid with the numerical optimization of a ram air–based TMS towards the minimum fuel burn of a 180-passenger short-range partial-turboelectric aircraft with a power split of up to 30% electric power. The TMS was designed for the conditions at the top of the climb. For an aircraft with the maximum power split, the additional fuel burn caused by the TMS is 0.19%. Conditions occurring at a hot-day takeoff represent the most challenging off-design conditions for TMS. Steady-state cooling of all electric components with the designed TMS is possible during a hot-day takeoff if a small puller fan is utilized. Omitting the puller fan and instead oversizing the TMS is an alternative, but the fuel burn increase on aircraft level grows to 0.29%.
Template-based parasitic-aware optimization and retargeting of analog and RF integrated circuit layouts (2006)

Parasitic effects are extremely significant for the performance of analog and RF integrated circuits. Although layout retargeting for technology migration or specification update is able to preserve designers' intent, the associated layout parasitics cannot be guaranteed to meet the performance requirements. In this paper, we present a novel algorithm that performs parasitic-aware automatic layout retargeting for analog/RF integrated circuits. Given parasitic resistance/capacitance bounds and matching constraints ensuring desired circuit performance, the algorithm creates a reduced-template-graph from original layouts and adds parasitic constraints. Using a two-dimensional hybrid scheme of graph-based optimization and nonlinear programming, the nonlinear problem is solved effectively and efficiently. The algorithm has successfully retargeted operational amplifiers and an RF low-noise amplifier within minutes of CPU time.
Transgenic Kalanchoë blossfeldiana, Containing Individual rol Genes and Open Reading Frames Under 35S Promoter, Exhibit Compact Habit, Reduced Plant Growth, and Altered Ethylene Tolerance in Flowers (2021)

Reduced growth habit is a desirable trait for ornamental potted plants and can successfully be obtained through <i>Rhizobium rhizogenes</i> transformation in a stable and heritable manner. Additionally, it can also be obtained by transformation with <i>Agrobacterium tumefaciens</i> harboring specific genes from <i>R. rhizogenes</i>. The bacterial T-DNA harbors four <i>root oncogenic loci</i> (<i>rol</i>) genes and 14 less known open reading frames (ORFs). The four <i>rol</i> genes, i.e., <i>rol</i>A, <i>rol</i>B, <i>rol</i>C, and <i>rol</i>D, are conceived as the common denominator for the compact phenotype and the other less characterized ORFs seem auxiliary but present a potential breeding target for less aberrant and/or more tailored phenotypes. In this study, <i>Kalanchoë blossfeldiana</i> 'Molly' was transformed with individual <i>rol</i> genes and selected ORFs in <i>35S</i> overexpressing cassettes to comprehensively characterize growth traits, gene copy and expression, and ethylene tolerance of the flowers. An association of reduced growth habit, e.g. height and diameter, was observed for <i>rol</i>B2 and ORF14-2 when a transgene single copy and high gene expression were detected. Chlorophyll content was reduced in overexpressing lines compared to wild type (WT), except for one ΔORF13a (a truncated ORF13a, where SPXX DNA-binding motif is absent). The flower number severely decreased in the overexpressing lines compared to WT. The anthesis timing showed that WT opened the first flower at 68.9 ± 0.9 days and the overexpressing lines showed similar or up to 24 days delay in flowering. In general, a single or low relative gene copy insertion was correlated to higher gene expression, ca. 3 to 5-fold, in <i>rol</i>B and ΔORF13a lines, while in ORF14 such relation was not directly linked. The increased gene expression observed in <i>rol</i>B2 and ΔORF13a-2 contributed to reducing plant growth and a more compact habit. Tolerance of detached flowers to 0.5 μl L<sup>-1</sup> ethylene was markedly higher for ORF14 with 66% less flower closure at day 3 compared to WT. The subcellular localization of <i>rol</i>C and ΔORF13a was investigated by transient expression in <i>Nicotiana benthamiana</i> and confocal images showed that <i>rol</i>C and ΔORF13a are soluble and localize in the cytoplasm being able to enter the nucleus.
Low-level factors increase gaze-guidance under cognitive load: A comparison of image-salience and semantic-salience models (2022)

Growing evidence links eye movements and cognitive functioning, however there is debate concerning what image content is fixated in natural scenes. Competing approaches have argued that low-level/feedforward and high-level/feedback factors contribute to gaze-guidance. We used one low-level model (Graph Based Visual Salience, GBVS) and a novel language-based high-level model (Global Vectors for Word Representation, GloVe) to predict gaze locations in a natural image search task, and we examined how fixated locations during this task vary under increasing levels of cognitive load. Participants (N = 30) freely viewed a series of 100 natural scenes for 10 seconds each. Between scenes, subjects identified a target object from the scene a specified number of trials (N) back among three distracter objects of the same type but from alternate scenes. The N-back was adaptive: N-back increased following two correct trials and decreased following one incorrect trial. Receiver operating characteristic (ROC) analysis of gaze locations showed that as cognitive load increased, there was a significant increase in prediction power for GBVS, but not for GloVe. Similarly, there was no significant difference in the area under the ROC between the minimum and maximum N-back achieved across subjects for GloVe (t(29) = -1.062, p = 0.297), while there was a cohesive upwards trend for GBVS (t(29) = -1.975, p = .058), although not significant. A permutation analysis showed that gaze locations were correlated with GBVS indicating that salient features were more likely to be fixated. However, gaze locations were anti-correlated with GloVe, indicating that objects with low semantic consistency with the scene were more likely to be fixated. These results suggest that fixations are drawn towards salient low-level image features and this bias increases with cognitive load. Additionally, there is a bias towards fixating improbable objects that does not vary under increasing levels of cognitive load.
Development of S-SLA's Grading Indicator based on the Analyses of IPS's Security Functions (2010)

Internet service providers provide various security services, such as firewall, intrusion detection, intrusion prevention, anti-virus, along with their main Internet services. Those security service users have no idea what kind of quality services they are guaranteed. And therefore, Internet users interest in Security Service Level Agreement(SLA) increases as their interest in secure Internet service increases. However, there wasn't any researches in the S-SLA area domestically and there are only limited SLA indexes related to system or service maintenances at the moment. Therefore, this paper analyses security functions in IPS services and categorize them into common and independent security functions. Finally to improve quality of security services, this paper proposes S-SLA indexes depending on the different security levels. This will be subdivide into agreement on security service.
High-voltage TFT fabricated in recrystallized polycrystalline silicon (1988)

High-voltage thin-film transistors (TFTs) fabricated using CW-Ar laser annealed polycrystalline silicon have an offset gate structure between the source and gate and between the gate and drain. The breakdown voltage, transconductance, and leakage current in various size TFTs are described. These TFTs exhibited n-channel enhancement characteristics with a low-threshold voltage, and a breakdown voltage above 100 V could be obtained at an offset gate length of 20 mu m. Active TFT circuits were fabricated with these high-voltage Si TFTs. These high-voltage TFT circuits can drive thin-film EL (electroluminescent display) at low signal voltage.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Overexpression of stromal cathepsin K expression correlates with invasiveness of extramammary Paget's disease (2010)

Auteur(s) : Lining Xie1, Sayaka Hayashida1, Xiaofeng Yan1,2, Gaku Tsuji1, Takeshi Nakahara1, Satoshi Takeuchi1, Masakazu Takahara1, Baoen Shan3, Hiroshi Uchi1, Yoichi Moroi1, Masutaka Furue1 1Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan 2Department of Dermatology, Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan, China 3Research Center, the Fourth [...]
Fabrication of high aspect ratio silicon microstructures by anodic etching (1997)

We describe a refinement of the anodization process commonly used for the formation of porous silicon, which allows the fabrication of arrays of very high aspect ratio sub-micron pores and free-standing pillars. These structures are shown to possess a wide photonic band gap in the near infra red.
Enamines from iodine oxidation of trialkylamines. 1. Electrophilic capture by cationic heterocyclic rings (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnamines from iodine oxidation of trialkylamines. 1. Electrophilic capture by cationic heterocyclic ringsDonald H. Wadsworth, Michael R. Detty, Bruce J. Murray, Charles H. Weidner, and Neil F. HaleyCite this: J. Org. Chem. 1984, 49, 15, 2676–2681Publication Date (Print):July 1, 1984Publication History Published online1 May 2002Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/jo00189a004https://doi.org/10.1021/jo00189a004research-articleACS PublicationsRequest reuse permissionsArticle Views572Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Melphalan, prednisone, and lenalidomide versus melphalan, prednisone, and thalidomide in untreated multiple myeloma (2016)

The combination of melphalan, prednisone, and thalidomide (MPT) is considered standard therapy for newly diagnosed patients with multiple myeloma who are ineligible for stem cell transplantation. Long-term treatment with thalidomide is hampered by neurotoxicity. Melphalan, prednisone, and lenalidomide, followed by lenalidomide maintenance therapy, showed promising results without severe neuropathy emerging. We randomly assigned 668 patients between nine 4-week cycles of MPT followed by thalidomide maintenance until disease progression or unacceptable toxicity (MPT-T) and the same MP regimen with thalidomide being replaced by lenalidomide (MPR-R). This multicenter, open-label, randomized phase 3 trial was undertaken by Dutch-Belgium Cooperative Trial Group for Hematology Oncology and the Nordic Myeloma Study Group (the HOVON87/NMSG18 trial). The primary end point was progression-free survival (PFS). A total of 318 patients were randomly assigned to receive MPT-T, and 319 received MPR-R. After a median follow-up of 36 months, PFS with MPT-T was 20 months (95% confidence interval [CI], 18-23 months) vs 23 months (95% CI, 19-27 months) with MPR-R (hazard ratio, 0.87; 95% CI, 0.72-1.04; P = .12). Response rates were similar, with at least a very good partial response of 47% and 45%, respectively. Hematologic toxicity was more pronounced with MPR-R, especially grades 3 and 4 neutropenia: 64% vs 27%. Neuropathy of at least grade 3 was significantly higher in the MPT-T arm: 16% vs 2% in MPR-R, resulting in a significant shorter duration of maintenance therapy (5 vs 17 months in MPR-R), irrespective of age. MPR-R has no advantage over MPT-T concerning efficacy. The toxicity profile differed with clinically significant neuropathy during thalidomide maintenance vs myelosuppression with MPR.
Stability study, method for the quantitation of a new antifilovirus agent in biological fluids and a preliminary study of its pharmacokinetics (2020)

The stability of the new antifiloviral agent AS-358 consisting of borneol and 3-(piperidin-1-yl)propanoic acid, was studied in the blood and blood plasma of rats in vitro. It was found that in both matrices stabilized by EDTA or heparin, the compound is rapidly hydrolyzed at the ester bond. When sodium fluoride was added, the decomposition of the compound was significantly slowed down. This made it possible to develop and validate a method for the quantitative determination of the agent in whole rat blood. Analysis was performed by HPLC-MS/MS method using reverse phase chromatography. The developed method was used for a preliminary study of the pharmacokinetics of the agent AS-358 after its oral administration to rats, and it was shown that the concentration of AS-358 in the blood of animals reached 550 ng/ml after 1 hour, despite its instability in blood. Analogues of the agent which contain ether linker have been synthesized and their metabolic stability has been shown.
Identification of a Potential Susceptibility Locus for Macular Telangiectasia Type 2 (2012)

Macular Telangiectasia type 2 (MacTel) is a relatively rare macular disease of adult onset presenting with distortions in the visual field and leading to progressive loss of visual acuity. For the purpose of a gene mapping study, several pedigrees were ascertained with multiple affected family members. Seventeen families with a total of 71 individuals (including 45 affected or possibly affected) were recruited at clinical centers in 7 countries under the auspices of the MacTel Project. The disease inheritance was consistent with autosomal dominant segregation with reduced penetrance. Genome-wide linkage analysis was performed, followed by analysis of recombination breakpoints. Linkage analysis identified a single peak with multi-point LOD score of 3.45 on chromosome 1 at 1q41-42 under a dominant model. Recombination mapping defined a minimal candidate region of 15.6 Mb, from 214.32 (rs1579634; 219.96 cM) to 229.92 Mb (rs7542797; 235.07 cM), encompassing the 1q41-42 linkage peak. Sanger sequencing of the top 14 positional candidates genes under the linkage peak revealed no causal variants in these pedigrees.
Near-Field Coupling Effects in Mie-Resonant Photonic Structures and All-Dielectric Metasurfaces (2018)

We reveal that strong near-field coupling effects can be observed for dissimilar Mie-resonant dielectric meta-atoms and demonstrate that both properties and functionalities of high-index all-dielectric photonic structures can be controlled by engineering their geometry and changing the distance between meta-atoms thus enhancing the effective magnetic response. We describe dielectric dimers, quadrumers, and metasurfaces with a staggered structure of optically induced magnetic moments (the so-called ”optical antiferromagnetism”) and also demonstrate that a strong toroidal response can be introduced in metasurfaces by engineering asymmetric nanoparticle quadrumers as building blocks for novel designs in all-dielectric resonant meta-optics.