gebhart/patrepeval huggingface dataset:
Awake mouse brain photoacoustic and optical imaging through a transparent ultrasound cranial window (2021)

Abstract Optical resolution photoacoustic microscopy (OR-PAM) can map the cerebral vasculature at capillary level resolution. However, the OR-PAM setup’s bulky imaging head makes awake mouse brain imaging challenging and inhibits its integration with other optical neuroimaging modalities. Moreover, the glass cranial windows used for optical microscopy are unsuitable for OR-PAM due to the acoustic impedance mismatch between the glass plate and the tissue. To overcome these challenges, we propose a lithium niobate based transparent ultrasound trans-ducer (TUT) as a cranial window on a thinned mouse skull. The TUT cranial window simplifies the imaging head considerably due to its dual functionality as an optical window and ultrasound transducer. The window remains stable for six weeks, with no noticeable inflammation and minimal bone regrowth. The TUT window’s potential is demonstrated by imaging the awake mouse cerebral vasculature using OR-PAM, intrinsic optical signal imaging and two-photon microscopy. The TUT cranial window can potentially also be used for ultrasound stimulation and simultaneous multimodal imaging of the awake mouse brain.
Control Strategy of Two Capacitor Voltages for Separate MPPTs in Photovoltaic Systems Using Neutral-Point-Clamped Inverters (2015)

The centralized topology with three-level inverters are widely used in photovoltaic (PV) systems due to their less installation costs and complexity. However, the common maximum power point tracking (MPPT) is a disadvantage of the centralized topology particularly under the partial shading and panel mismatch conditions. In this system, if PV modules are separately connected to the split capacitor voltage, the MPPT efficiency can be improved by the proposed control strategy. By the proposed method, the two capacitor voltages can be controlled asymmetrically to perform the separate MPPTs of each PV module connected to separate capacitors. The outputs can be generated without distortion even if two capacitors are asymmetrically regulated. Simulation and experimental results verify the validity and feasibility of the proposed methods.
Photodynamic therapy with indocyanine green for occult subfoveal choroidal neovascularization caused by age-related macular degeneration (2001)

i-PDT induced CNV regression and improved the visual acuity in these particular cases, suggesting a new and promising way to treat neovascular AMD. The partial anatomical restoration associated to the improvement of the visual function observed in both patients suggests that a selective therapeutic effect was achieved. Further studies are required not only to assess the clinical value of this treatment but also to better understand the major mechanism of action involving this novel treatment modality.
Degenerate four-wave mixing in semiconductor-doped glasses below the absorption edge (1999)

We report measurements of degenerate four-wave-mixing reflectivity at a frequency below the band gap of semiconductor-doped glasses in the intensity range 0.5--10 ${\mathrm{G}\mathrm{W}/\mathrm{c}\mathrm{m}}^{2}$. Up to intensities \ensuremath{\sim}2.5 ${\mathrm{G}\mathrm{W}/\mathrm{c}\mathrm{m}}^{2}$, the conjugate reflectivity varies like the fourth power of intensity signifying a fifth-order nonlinearity due to band filling by two-photon absorption. Surprisingly, at a higher intensity range the conjugate signal showed a cubic dependence on the pump intensity, which is typical of the ${\ensuremath{\chi}}^{(3)}$ process. We show that this cubic dependence does not necessarily indicate a third-order process as usually assumed. Instead, it is shown to arise due to a reduction of the effective intensity by nonlinear absorption of the interacting beams.
A portable thermoelectric-power-generating module composed of oxide devices (2006)

High power density is a strong point of thermoelectric generation. Exploitation of this salient characteristic would make thermoelectric modules promising candidates for mobile power applications. Here we show how power can be generated using a small thermoelectric module composed of 140 pairs of oxide thermoelectric unicouples. The module weighs 19.8g and its dimensions are 53mm long, 32mm wide, and 5.0mm thick. The hot-pressed thermoelectric oxide bulk materials used were connected with a Ag paste, incorporating oxide powder, and Ag electrodes. The module’s open circuit voltage increases with increasing hot-side temperature (TH) and reaches 4.5V at a TH of 1072K in air. No deterioration in output power was seen when power generation was carried out ten times at a TH of 723K with intermediate cooling to room temperature. The module was successfully used to charge a lithium-ion battery in a mobile phone.
Preparation, Absolute Configuration and Conformation of Some α-Aryl-2-pyridylmethanols (1987)

Abstract The syntheses of five optically active α-aryl-2-pyridylmethanols 1–5 are described. It is shown by means of chemical correlation with the known (−)-(αR,2S)-α-phenyl-2-piperidylmethanol 6 that all levo-rotatory isomers of 1–4 are of R configuration. It is also found via the relative integral intensities in the infrared spectra of the bands due to free and intramolecularly bonded hydroxyl groups in the compounds 1–4 and the free hydroxyl groups in the model compounds 7–10, that the population of the conformers with an intramolecular OH···N bond in compounds 1–4 exceeds 80%.
Observation of the Wannier-Stark Quantization in a Semiconductor Superlattice (1988)

When an electric field $F$ is applied parallel to the growth axis of a semiconductor superlattice, the eigenstates are quantized and strongly localized. This Wannier-Stark quantization manifests itself as an effective blue shift of the optical-absorption edge and is accompanied by a new type of electro-optical oscillation of the absorption coefficient which is periodic in ${F}^{\ensuremath{-}1}$. We report experimental evidences for these theoretical predictions from the study of the low-temperature electroreflectance of a GaAs-AlGaAs superlattice.
Pharmacology education in nursing based on the Patient-oriented Pharmacology: Personal drug (P-Drug) and integrated Drug (iDrug) (2018)

The installation of nursing colleges/universities has rapidly increased from the late 1990s, there are 255 institutions in Japan as of 2017. Pharmacology and clinical pharmacology education in undergraduate and postgraduate nursing colleges/universities is highly important, however, the lack of human resources involved in pharmacology education due to the rapid increase of nursing colleges/universities cannot be denied. The Ministry of Education, Culture, Sports, Science and Technology of Japan established a 〝nursing education model core curriculum〟 for quality assurance of education at nursing colleges/universities. To meet the needs of a new phase of nursing education, re-examination of curriculum of nursing Pharmacology education is necessary. In this manuscript, we would like to propose a novel concept 〝integrated drug (iDrug)〟 based on 〝Patient-oriented Pharmacology〟 for nursing Pharmacology education to maintain high level of safety medication.
PHIT for Duty, a Mobile Application for Stress Reduction, Sleep Improvement, and Alcohol Moderation (2018)

Post-traumatic stress and other problems often occur after combat, deployment, and other military operations. Because techniques such as mindfulness meditation show efficacy in improving mental health, our team developed a mobile application (app) for individuals in the armed forces with subclinical psychological problems as secondary prevention of more significant disease. Based on the Personal Health Intervention Toolkit (PHIT), a mobile app framework for personalized health intervention studies, PHIT for Duty integrates mindfulness-based relaxation, behavioral education in sleep quality and alcohol use, and psychometric and psychophysiological data capture. We evaluated PHIT for Duty in usability and health assessment studies to establish app quality for use in health research. Participants (N = 31) rated usability on a 1 (very hard) to 5 (very easy) scale and also completed the System Usability Scale (SUS) questionnaire (N = 9). Results were (mean ± SD) overall (4.5 ± 0.6), self-report instruments (4.5 ± 0.7), pulse sensor (3.7 ± 1.2), sleep monitor (4.4 ± 0.7), sleep monitor comfort (3.7 ± 1.1), and wrist actigraphy comfort (2.7 ± 0.9). The average SUS score was 85 ± 12, indicating a rank of 95%. A comparison of PHIT-based assessments to traditional paper forms demonstrated a high overall correlation (r = 0.87). These evaluations of usability, health assessment accuracy, physiological sensing, system acceptability, and overall functionality have shown positive results and affirmation for using the PHIT framework and PHIT for Duty application in mobile health research.
Image browsing, processing, and clustering for participatory sensing (2007)

Imagers are an increasingly significant source of sensory observations about human activity and the urban environment. ImageScape is a software tool for processing, clustering, and browsing large sets of images. Implemented as a set of web services with an Adobe Flash-based user interface, it supports clustering by both image features and context tags, as well as re-tagging of images in the user interface. Though expected to be useful in many applications, ImageScape was designed as an analysis component of DietSense, a software system under development at UCLA to support (1) the use of mobile devices for automatic multimedia documentation of dietary choices with just-in-time annotation, (2) efficient post facto review of captured media by participants and researchers, and (3) easy authoring and dissemination of the automatic data collection protocols. A pilot study, in which participants ran software that enabled their phones to autonomously capture images of their plates during mealtime, was conducted using an early prototype of the DietSense system, and the resulting image set used in the creation of ImageScape. ImageScape will support two kinds of users within the DietSense application: The participants in dietary studies will have the ability to easily audit their images, while the recipients of the images, health care professionals managing studies and performing analysis, will be able to rapidly browse and annotate large sets of images.
Zn2+ binding to human calbindin D28k and the role of histidine residues (2008)

We have studied the binding of Zn2+ to the hexa EF-hand protein, calbindin D(28k)-a strong Ca2+-binder involved in apoptosis regulation-which is highly expressed in brain tissue. By use of radioblots, isothermal titration calorimetry, and competition with a fluorescent Zn2+ chelator, we find that calbindin D(28k) binds Zn2+ to three rather strong sites with dissociation constants in the low micromolar range. Furthermore, we conclude based on spectroscopic investigations that the Zn2+-bound state is structurally distinct from the Ca2+-bound state and that the two forms are incompatible, yielding negative allosteric interaction between the zinc- and calcium-binding events. ANS titrations reveal a change in hydrophobicity upon binding Zn2+. The binding of Zn2+ is compatible with the ability of calbindin to activate myo-inositol monophosphatase, one of the known targets of calbindin. Through site-directed mutagenesis, we address the role of cysteine and histidine residues in the binding of Zn2+. Mutation of all five cysteines into serines has no effect on Zn2+-binding affinity or stoichiometry. However, mutating histidine 80 into a glutamine reduces the binding affinity of the strongest Zn2+ site, indicating that this residue is involved in coordinating the Zn2+ ion in this site. Mutating histidines 5, 22, or 114 has significantly smaller effects on Zn2+-binding affinity.
Effector role of blood monocytes in experimental visceral leishmaniasis (1993)

In BALB/c mice, liver granulomas provoked by visceral infection with intracellular Leishmania donovani are rapidly populated by influxing blood monocytes. To determine the host defense effector role of these mononuclear phagocytes, we treated three populations of infected animals with 5C6, an anti-type 3 complement receptor monoclonal antibody (MAb), which inhibits monocyte recruitment into inflamed tissues. In naive BALB/c mice, injections of 5C6 impaired the initial acquisition of antileishmanial resistance and arrested the development of mature liver granulomas. In sensitized mice with established immunity, both resistance to rechallenge and accelerated granuloma formation were similarly inhibited by MAb administration. Finally, in naive mice, 5C6 MAb also abolished the antileishmanial activity induced by treatment with the macrophage-activating lymphokine gamma interferon. Together, these results suggest a key effector role for the influxing blood monocyte in both initial and established antileishmanial defense and granuloma assembly and in the infected liver as the mononuclear phagocyte target for the antimicrobial effects of gamma interferon.
Parallelizing data race detection (2013)

Detecting data races in multithreaded programs is a crucial part of debugging such programs, but traditional data race detectors are too slow to use routinely. This paper shows how to speed up race detection by spreading the work across multiple cores. Our strategy relies on uniparallelism , which executes time intervals of a program (called epochs ) in parallel to provide scalability, but executes all threads from a single epoch on a single core to eliminate locking overhead. We use several techniques to make parallelization effective: dividing race detection into three phases, predicting a subset of the analysis state, eliminating sequential work via transitive reduction, and reducing the work needed to maintain multiple versions of analysis via factorization. We demonstrate our strategy by parallelizing a happens-before detector and a lockset-based detector. We find that uniparallelism can significantly speed up data race detection. With 4x the number of cores as the original application, our strategy speeds up the median execution time by 4.4x for a happens-before detector and 3.3x for a lockset race detector. Even on the same number of cores as the conventional detectors, the ability for uniparallelism to elide analysis locks allows it to reduce the median overhead by 13% for a happens-before detector and 8% for a lockset detector.
Organotypic Co‐Cultures of Rat Locus Coeruleus and Hippocampus (1989)

Slices from the brainstem at the level of the locus coeruleus and from the hippocampus of 5 - 7 day old rats were co-cultured using the roller tube technique. After 2 - 6 weeks in vitro the co-cultures were examined with antibodies raised against tyrosine-hydroxylase (TH). The cultures derived from the brainstem consistently contained a bilateral cluster of TH-positive neurons with 3 - 5 long slender dendrites. These neurons typically gave rise to several fine varicose fibres reminiscent of catecholaminergic axons. A morphologically distinct group of TH-positive neurons was detected in the hippocampal slices. The vast majority of them were located in the subicular region and a smaller number in the CA1/CA3 region of the hippocampal explant. TH-positive neurons were also present in mono-cultures of hippocampus or brainstem. In the vast majority of co-cultures, a variable number of TH-immunoreactive fibres of neurons derived from the locus coeruleus grew over considerable distances to terminate finally within the co-cultured hippocampus where they branched to form a diffuse innervation plexus with club-like endings. Even after several weeks in vitro, TH-positive fibres could still be seen exploring sites which were not related to their target, including the cell-free areas surrounding the cultures. Fibres in these outgrowth areas formed whirl-like endings. TH-positive fibres arising from neurons located in the hippocampus, on the other hand, did not branch extensively and never projected over long distances. Nerve growth factor had no apparent trophic effect on TH-positive cells in the hippocampus, the locus coeruleus, or in the co-cultures.
Abstract A39: Pomhex, a cell-permeable high potency enolase inhibitor with utility for collateral lethality treatment of cancer (2017)

Abstract Glycolysis inhibition is an active area of investigation for the treatment of cancer. However, few compounds have progressed beyond the cell culture stage. We have recently demonstrated that genomic passenger deletion of the glycolytic enzyme Enolase 1 (ENO1) leaves gliomas harboring such deletions solely reliant on ENO2, rendering them exquisitely sensitive to enolase inhibitors Collateral Lethality. However, the tool compound that we employed for these in vitro studies, Phosphonoacetohydroxamate (PhAH), has very poor pharmacological properties and was ineffective in vivo. We recently reported that a structural analogue of PhAH, the natural phosphonate antibiotic SF2312, is a high potency inhibitor of Enolase. While more potent than PhAH, SF2312 remains poorly cell permeable. Here, we generated a Pivaloyloxymethyl (POM) ester pro-drug derivative of SF2312, termed POMSF, which increased the potency in cell based systems by ~50-fold. POMSF is selectively active against ENO1-deleted glioma cells in culture at ~19 nM, versus μM for SF2312. However, POMSF displayed poor aqueous stability. A derivative of POMSF, termed POMHEX, showed greater stability and its active form, HEX, showed 4-fold preference for ENO1 over ENO2. Labeled 13C-glucose tracing shows that POMHEX inhibits glycolysis at the Enolase step in all cell lines tested, but with ~100-fold greater potency in ENO1-deleted lines. POMHEX selectively killed ENO1-deleted glioma cells with an IC50 &amp;lt;30nM, whilst non-deleted cells could readily tolerate μM levels of inhibitor. As such, POMHEX was selected for in vivo experiments. Using an orthotopic intracranial xenografted model where tumor growth and response to therapy are monitored by MRI, we show that POMHEX is capable of eradicating intracranial ENO1-deleted tumors, with mice remaining recurrence-free even after treatment discontinuation. Taken together, these results reinforce that glycolysis is a viable target and provide in vivo proof-of-principal for the concept of using passenger deletions as targetable vulnerabilities in personalized cancer therapy. Citation Format: Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Federica Pisaneschi, Paul Leonard, David Maxwell, Zhenghong Peng, Todd Link, Lee IV R. Gilbert, Ananth Bosajou, Duoli Sun, Joe Marszalek, Yuting Sun, John S. McMurray, Pijus K. Mandal, Maria E. Di Francesco, Barbara Czako, Alan Wang, William Bornmann, Ronald A. DePinho, Florian Muller. Pomhex, a cell-permeable high potency enolase inhibitor with utility for collateral lethality treatment of cancer [abstract]. In: Proceedings of the AACR Precision Medicine Series: Opportunities and Challenges of Exploiting Synthetic Lethality in Cancer; Jan 4-7, 2017; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2017;16(10 Suppl):Abstract nr A39.
Ultra High Speed Electronics Based On Proposed High T c Superconductor Switching Devices (1988)

The development of superconductivity near 100 K allows hybrid superconductor/semiconductor electronic devices to be experimentally investigated as a means of realizing improved ultra high speed very large scale integration (VLSI) electronics. Incorporating superconductors into conventional semiconductor structures will be the most likely approach to developing hybrid VLSI devices. The analysis of passive hybridization (using superconductive interconnects) of semiconductor devices concludes that this approach might produce significant benefits in at least some cases. Active hybridization of semiconductor devices, in which the inclusion of superconductors in a semiconductor device significantly alters device operation, is treated briefly. Such devices might be a means of achieving revolutionary rather than evolutionary improvement of electronic systems. The hybridization schemes are illustrated with a proposed ultra high speed resonant tunneling transistor (RTT) structure and with hybrid MOSFET structures. From the processing perspective, rapid isothermal processing (RIP) based on incoherent light sources is a promising technology for the fabrication of hybrid devices.
Transcription of eucaryotic tRNAmet1and 5SRNA genes by RNA polymerase III is blocked by base mismatches in the intragenic control regions (1987)

We have constructed duplex DNAs containing single G-T or A-C mismatches in the X. laevis tRNA1met gene. Mismatches within regions of this gene which are bound by transcription factor TFIIIC prevent transcription by RNA polymerase III. Homoduplexes with G-C----A-T mutations at some of the same sites, however, are transcribed efficiently in oocytes. Mismatches outside of the tRNA1met gene have no effect upon transcription. A survey of several point mutants in the Syrian hamster 5SRNA gene indicates that mismatches outside the internal control region somewhat reduce transcription, but a mismatch within the internal control region blocks transcription. Thus, the presence of mismatched bases in the region of DNA which interacts with RNA polymerase III transcription factors blocks transcription, perhaps by interfering with DNA renaturation following transit of the RNA polymerase.
Enaminonitriles in Heterocyclic Synthesis: New Routes for the Synthesis of Some Novel Azolo[1,5-a]pyrimidine, Pyrimido[1,2-a]benzimidazole, Pyrido[1,2-a]benimdazole, Pyrazolo[3,4-b]pyridine, Pyrazole and Pyrimidine Derivatives (2000)

The synthesis of several new azolo[1,5- a]pyrimidines, pyrimido[1,2- a]benzimidazoles, pyrazolo[3,4- b]pyridines, pyrido[1,2- a]benzimidazoles, pyrazoles and pyrimidines is reported.
Determination of Molecular Structure of Hydrocarbon Olefins by High Resolution Nuclear Magnetic Resonance. (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Molecular Structure of Hydrocarbon Olefins by High Resolution Nuclear Magnetic Resonance.F. C. Stehling and K. W. BartzCite this: Anal. Chem. 1966, 38, 11, 1467–1479Publication Date (Print):October 1, 1966Publication History Published online1 May 2002Published inissue 1 October 1966https://pubs.acs.org/doi/10.1021/ac60243a006https://doi.org/10.1021/ac60243a006research-articleACS PublicationsRequest reuse permissionsArticle Views94Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gemfibrozil Concentrations Are Significantly Decreased in the Presence of Lopinavir-Ritonavir (2009)

Lopinavir-ritonavir significantly reduced the systemic exposure of gemfibrozil by reducing gemfibrozil absorption. Clinicians treating HIV-infected patients with hypertriglyceridemia should be aware of this drug interaction.
Summary of work on shock wave feature extraction in 3-D datasets (1996)

A method for extracting and visualizing shock waves from three dimensional data-sets is discussed. Issues concerning computation time, robustness to numerical perturbations, and noise introduction are considered and compared with other methods. Finally, results using this method are discussed.