gebhart/patrepeval huggingface dataset:
Adoptive Natural Killer Cell Immunotherapy for Canine Osteosarcoma (2021)

Osteosarcoma is the most common primary bone tumor in both humans and dogs. It is a highly metastatic cancer and therapy has not improved significantly since the inclusion of adjuvant chemotherapy into disease treatment strategies. Osteosarcoma is an immunogenic tumor, and thus development of immunotherapies for its treatment, especially treatment of microscopic pulmonary metastases might improve outcomes. NK cells are lymphocytes of the innate immune system and can recognize a variety of stressed cells, including cancer cells, in the absence of major histocompatibility complex (MHC)-restricted receptor ligand interactions. NK cells have a role in controlling tumor progression and metastasis and are important mediators of different therapeutic interventions. The core hypothesis of adoptive natural killer (NK) cell therapy is there exists a natural defect in innate immunity (a combination of cancer-induced reduction in NK cell numbers and immunosuppressive mechanisms resulting in suppressed function) that can be restored by adoptive transfer of NK cells. Here, we review the rationale for adoptive NK cell immunotherapy, NK cell biology, TGFβ and the immunosuppressive microenvironment in osteosarcoma, manufacturing of <i>ex vivo</i> expanded NK cells for the dog and provide perspective on the present and future clinical applications of adoptive NK cell immunotherapy in spontaneous osteosarcoma and other cancers in the dog.
Synthesis and Characterization of Block Copolymers of ε‐Caprolactone and DL‐Lactide Initiated by Ethylene Glycol or Poly(ethylene glycol) (2003)

Abstract Biodegradable copolymers were prepared by ring‐opening polymerization of sequentially added ε ‐caprolactone and DL ‐lactide in the presence of ethylene glycol or poly(ethylene glycol), using zinc metal as catalyst. Polymerization was performed in bulk and yielded block copolymers with predetermined PEG/PCL/PLA segments. The obtained polymers were characterized by 1 H NMR, SEC, IR, DSC, TGA, and X‐ray diffraction. Data showed that the copolymers preserved the excellent thermal behavior inherent to PCL. The crystallinity of PLA‐containing copolymers was reduced with respect to PCL homopolymer. The presence of both hydrophilic PEG and fast degrading PLA blocks should improve the biocompatibility and biodegradability of the materials, which are of interest for applications as substrate in drug delivery or as scaffolding in tissue engineering. Block copolymerization of ε ‐caprolactone and DL ‐lactide initiated by dihydroxyl PEG. magnified image Block copolymerization of ε ‐caprolactone and DL ‐lactide initiated by dihydroxyl PEG.
MPI and communication---Software routing and aggregation of messages to optimize the performance of HPCC randomaccess benchmark (2006)

The HPC Challenge(HPCC) benchmark suite is increasingly being used to evaluate the performance of supercomputers. It augments the traditional LINPACK benchmark by adding six more benchmarks, each designed to measure a specific aspect of the system performance.In this paper, we analyze the HPCC Randomaccess benchmark which is designed to measure the performance of random memory updates. We show that, on many systems, the bisection bandwidth of the network may be the performance bottleneck of this benchmark. We suggest an aggregation and software routing based technique that may be used to optimize this benchmark. We report the performance results obtained using this technique on the Blue Gene/L supercomputer.
Quality of telecommunications as a composition of qualities of subservices, including security and trusted third parties (2017)

Conceptual models of overall telecommunication system are developed and used for definition of scalable Quality of Service (QoS) Indicators towards better QoS monitoring, prediction and management. The telecom system, including calling (A), called (B)-users and terminals and Trusted Third Parties, is considered consisting of ten service stages. Each service stage, including Information Security Stage, has own characteristics of service. The QoS of the overall network and system are presented as compositions of the service stages' QoS indicators.
Der Schnitt von Blechtafeln und Bandstahl mit Kreismesserscheren (1960)

Anwendungsbereiche von Kreis-Langmesserscheren und Kreismesserscheren. Verteilung der äußeren Kräfte an der Schnittzone und Lage des Bleches zu den Schneidkanten. Folgerung für die Ausbildung der Kreismesser. Vorgänge im Werkstoff beim Schneidvorgang. Einfluß der Verhältnisse s/R und B/s auf die Ausbildung der Schnittkante. Verfestigung des Werkstoffes beim Schnitt. Berechnung von Kraft- und Leistungsbedarf an Kreis-Langmesser- und Kreismesserscheren und Hinweise zur Auslegung von Kreismesser-Schneidmaschinen auf Grund von Versuchen an Blechen von 0,5 bis 10 mm Dicke.
Analytic characterizations of infinite dimensional distributions (2017)

We revisit the analytic characterization theorem for S-transform of infinite dimensional distributions. Then we prove that the nuclearity of the space of test white noise functionals is a necessary condition for the characterization of the S-transform in terms of analytic and growth conditions.
Redox Polymers for Tissue Engineering (2021)

This review will focus on the targeted design, synthesis and application of redox polymers for use in regenerative medicine and tissue engineering. We define redox polymers to encompass a variety of polymeric materials, from the multifunctional conjugated conducting polymers to graphene and its derivatives, and have been adopted for use in the engineering of several types of stimulus responsive tissues. We will review the fundamental properties of organic conducting polymers (OCPs) and graphene, and how their properties are being tailored to enhance material - biological interfacing. We will highlight the recent development of high-resolution 3D fabrication processes suitable for biomaterials, and how the fabrication of intricate scaffolds at biologically relevant scales is providing exciting opportunities for the application of redox polymers for both <i>in-vitro</i> and <i>in-vivo</i> tissue engineering. We will discuss the application of OCPs in the controlled delivery of bioactive compounds, and the electrical and mechanical stimulation of cells to drive behaviour and processes towards the generation of specific functional tissue. We will highlight the relatively recent advances in the use of graphene and the exploitation of its physicochemical and electrical properties in tissue engineering. Finally, we will look forward at the future of organic conductors in tissue engineering applications, and where the combination of materials development and fabrication processes will next unite to provide future breakthroughs.
Use of Unstructured Event-Based Reports for Global Infectious Disease Surveillance (2009)

Free or low-cost sources of unstructured information, such as Internet news and online discussion sites, provide detailed local and near real-time data on disease outbreaks, even in countries that lack traditional public health surveillance. To improve public health surveillance and, ultimately, interventions, we examined 3 primary systems that process event-based outbreak information: Global Public Health Intelligence Network, HealthMap, and EpiSPIDER. Despite similarities among them, these systems are highly complementary because they monitor different data types, rely on varying levels of automation and human analysis, and distribute distinct information. Future development should focus on linking these systems more closely to public health practitioners in the field and establishing collaborative networks for alert verification and dissemination. Such development would further establish event-based monitoring as an invaluable public health resource that provides critical context and an alternative to traditional indicator-based outbreak reporting.
ChemInform Abstract: DIHYDROTHIOPHENES PART 2, PREPARATION AND PROPERTIES OF SOME ALKYLATED 2,5‐DIHYDROTHIOPHENES (1974)

Abstract Aus den Mercaptoketonen (I) und den AIkenyLphosphoniumsalzen (II) entstehen dif Dihydrothiophene (III).
Inflation, Taxes, and Optimal Inventory Policies (1985)

Inventory valuation, Taxes, Inflation, Optimal cost flow
A fast centrifuge method for nematocyst isolation from Pelagia noctiluca Forskal (Cnidaria: Scyphozoa). (2005)

Nematocyst isolation from surrounding tissue is an important step to characterize Cnidarian venom. Although several protocols have been used to extract venoms from cnidarian tissues, the complete isolation of nematocysts from tissue is still difficult. The goal of the present work was to evaluate the effectiveness of three different media, Percoll, Ficoll and Methylcellulose in isolating nematocysts from Pelagia noctiluca tentacles by centrifugation. The complete sedimentation of nematocysts and tissue fragments to the bottom of the test tubes was observed in Ficoll and Methylcellulose suspensions. The best result was obtained using a discontinuous density gradient of Percoll: three types of nematocysts were concentrated in three different fractions along the density gradient. Protein assay and preliminary chromatographic analyses confirmed these results.
Abstract 3570: Investigating coding and non-coding RNA in papillary thyroid cancer (2019)

Thyroid cancer is among the most common endocrine malignancies, with papillary thyroid cancer (PTC) accounting for approximately 80% of new thyroid cancer cases in 2017 (ACS). Despite the high sensitivity (95%) of ultrasound-guided fine needle aspiration biopsies (FNAB), approximately 20% of FNA biopsies are indeterminate, which require resection, despite the fact that about 50% are benign. The outcome is that many patients undergo surgical resection of benign disease resulting in avoidable iatrogenic morbidity, and about $700 million in health care costs. Thus, identifying diagnostic/prognostic molecular signatures of PTC would greatly reduce the number of costly, unnecessary resections following indeterminate biopsies. Following consenting of NYEEI patients, surgery, and diagnosis by the pathologist, RNA was prepared from PTC and matched-normal tissue samples, rRNA eliminated and RNA-Seq performed (100bp, paired-end). STARv2.5.2b/ htseq-countv0.6.1 and DESeq2 were used to align raw sequences, and measure transcript abundance. Preliminary bioinformatics analysis was performed with Advaita's iPathway Software. Over 1500 protein-coding transcripts, and 386 lincRNAs achieved 1.5 fold level differential expression (p= 0.05). Gene Ontology enrichment analysis indicated that locomotion, cell motility, signaling, cell differentiation and cell communication were among the most statistically significantly biological processes altered between PTC and matched-normal tissue. Cytokine, signal transducer, ion channel activity, receptor and growth factor activities were among the most statistically significantly molecular functions altered between PTC and matched, normal tissue. Additionally, Pathway Analysis indicated that cell adhesion molecules, cytokine-cytokine receptor, ECM-receptor, cancer, proteoglycans and Jak-Stat signaling were significantly altered. Thyroid differentiation scores (TDS) were calculated for each patients and correlations between differentially expressed lincRNA’s and the TDS were identified. We expect followup experiments modulating the expression of lincRNAs most strongly correlated to the TDS will augment the expression of iodine-handling genes and differentiation in PTC cell lines. We anticipate that the detailed bioinformatics analysis of our coding and noncoding databases in addition to evidence from in vitro studies will yield new diagnostic/prognostic biomarkers, and therapeutic targets.Citation Format: Sina Dadafarin, Anvita Gupta, Katharine Dermigny, Leyla Cavdar, Brandon Pecchia, Melanie Jones, Timmy O'Connell, JK Rasamny, Nina Suslina, Codrin Iacob, Monica Schwarcz, Ameet Kamat, Cameron Budenz, Craig Berzofsky, Deya Jourdy, Tali Lando, Stimson Schantz, Sarnath Singh, Edward Shin, Augustine Moscatello, Raj Tiwari, Jan Geliebter. Investigating coding and non-coding RNA in papillary thyroid cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3570.
DeFusionNET: Defocus Blur Detection via Recurrently Fusing and Refining Discriminative Multi-Scale Deep Features (2020)

Albeit great success has been achieved in image defocus blur detection, there are still several unsolved challenges, e.g., interference of background clutter, scale sensitivity and missing boundary details of blur regions. To deal with these issues, we propose a deep neural network which recurrently fuses and refines multi-scale deep features (DeFusionNet) for defocus blur detection. We first fuse the features from different layers of FCN as shallow features and semantic features, respectively. Then, the fused shallow features are propagated to deep layers for refining the details of detected defocus blur regions, and the fused semantic features are propagated to shallow layers to assist in better locating blur regions. The fusion and refinement are carried out recurrently. In order to narrow the gap between low-level and high-level features, we embed a feature adaptation module before feature propagating to exploit the complementary information as well as reduce the contradictory response of different feature layers. Since different feature channels are with different extents of discrimination for detecting blur regions, we design a channel attention module to select discriminative features for feature refinement. Finally, the output of each layer at last recurrent step are fused to obtain the final result. We collect a new dataset consists of various challenging images and their pixel-wise annotations for promoting further study. Extensive experiments on two commonly used datasets and our newly collected one are conducted to demonstrate both the efficacy and efficiency of DeFusionNet.
Effect of Environmental Factors on the Occurrence of <i>Vibrio vulnificus </i>in Costal Waters of Nagasaki Prefecture, Japan (2009)

長崎県沿岸の漁港7地点（有明海5地点，橘湾2地点）における海水中のVibrio vulnificus（V. vulnificus）菌数をMost probable number（MPN）-PCR 法を用いて測定し，その菌数の増減に及ぼす各種環境因子（水温，塩分濃度，DO，COD，総窒素量，総リン量，クロロフィルa量）の影響を海域性および季節性を加えながら統計学的に解析し，検討した． V. vulnificus菌数は，有明海では6月から菌数上昇傾向を示し7月に最高値（4.50 × 104 ±17.1 MPN/100ml）となり，橘湾では8月に最高値を示した． 両海域でのV. vulnificus菌数は，水温（rs ＝0.711）および塩分濃度（rs ＝－0.712）との間に高い相関を認めた． またDO，総窒素量およびクロロフィルa量とV. vulnificus菌数の間には，単回帰分析（R2 ＞0.1）で低度の寄与率が認められた． V. vulnificusは，有明海産魚介類からの分離率が橘湾のそれらよりも高く，二枚貝で90％および魚類で94.1％を示し，その菌数の最高値は106 MPN/100g であった．
Synthesis of epimeric 6-deuterio-4-cholesten-3-ones. (1977)

In order to clarify the stereochemistry of hydrogen transfer from C-4 to C-6 during enzymatic transformation of cholesterol into cholestenone, the title compounds stereospecifically labeled with deuterium have been synthesized as an authentic specimen. The stereospecific labeling at 6β was attained by trans-diaxial opening of the 5α, 6α-oxido ring with lithium aluminum deuteride. Oxidation with chromium trioxide followed by dehydration with p-toluenesulfonic acid provided 6β-d1-cholestenone (4a). In the similar fashion 6β-d1-cholestenone (4b) was prepared from 6β-d1-3α, 5-cyclo-5α-cholestan-6α-ol (6) by way of 6-d1-cholesteryl acetate (7).
Approximate SER of H-S/MRC in correlated Nakagami fading (2006)

An accurate approximation to the average symbol error rate of hybrid selection/maximal-ratio combining (H-S/MRC) in correlated Nakagami-m fading with positive integer values of m, is obtained by using a Green's matrix approximation. This approach is valid for different M-ary linear modulation schemes. We illustrate our methodology using M-ary phase-shift keying (MPSK) as an example
Spectrophotometric investigation of sensitive complexing agents for the determination of zinc in serum. (1985)

Of two sensitive complexometric reagents for the colorimetry of serum zinc that we investigated, one, 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol (Br-PADAP), was found to be a potentially useful compound for trace-metal determinations. It has a high molar absorptivity (120 000 L mol-1 cm-1) but is not convenient to use because it is not very soluble in water. The other reagent, a related pyridylazo compound, is 2-(5-bromo-2-pyridylazo)-5-(N-n-propyl-N-3-sulfopropylamino)phenol (5-BR-PAPS). It seems better suited for use in routine zinc determinations because, besides being water soluble, it has a higher molar absorptivity, 130 000 L mol-1 cm-1. Results by the proposed method developed with 5-Br-PAPS correlated well with those by atomic absorption spectrophotometry. The between-run CV for control sera was less than 5%; the within-run CV (same controls) was less than 4%.
An NCME Instructional Module on Data Mining Methods for Classification and Regression (2016)

Data mining methods for classification and regression are becoming increasingly popular in various scientific fields. However, these methods have not been explored much in educational measurement. This module first provides a review, which should be accessible to a wide audience in education measurement, of some of these methods. The module then demonstrates using three real‐data examples that these methods may lead to an improvement over traditionally used methods such as linear and logistic regression in educational measurement.
Dynamic state estimation‐based fault locating on transmission lines (2017)

Accurate fault locating minimises labour and outage time. Efforts to increase the accuracy of fault locating methods are on‐going. In this study, a dynamic state estimation‐based fault locating (EBFL) method is proposed. Best implementation requires GPS synchronised sample value measurements at both ends of the line. The dynamic state estimator operates on the sampled values using a detailed dynamic model of the line, which includes the fault location as a state. Specifically, the dynamic line model is represented as a multi‐section transmission line model, inclusive of phase conductor type and size, shield wire(s) type and size, and tower ground impedances, integrated with the fault model. This study presents extensive numerical experiments demonstrating that the method has higher accuracy than traditional fault locating methods for different fault types, locations and impedances. Additionally, the method works for both two‐terminal and three‐terminal transmission lines.
Effects of Channel Mobility on SiC Power Metal-Oxide-Semiconductor Field Effect Transistor Performance (1996)

The performance of 6H- and 4H-SiC power metal-oxide-semiconductor field effect transistors (MOSFETs) has been theoretically studied, taking account of channel resistances and mobility anisotropy. For low-voltage (&lt;500 V) devices, the total on-resistance is severely limited by the channel resistance, due to the very low drift-region resistance and to the relatively low channel mobility in SiC. Even in high-voltage (&gt;500 V) devices, a channel mobility higher than 50 cm 2 /Vs is required to ensure that SiC power MOSFETs are practical.
Biosynthetic studies of marine lipids. 5. The biosynthesis of long-chain branched fatty acids in marine sponges (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiosynthetic studies of marine lipids. 5. The biosynthesis of long-chain branched fatty acids in marine spongesNestor Carballeira, Janice E. Thompson, Eser Ayanoglu, and Carl DjerassiCite this: J. Org. Chem. 1986, 51, 14, 2751–2756Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/jo00364a024https://doi.org/10.1021/jo00364a024research-articleACS PublicationsRequest reuse permissionsArticle Views501Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sleep Traits, Night Shift Work and Lung Cancer Risk among Women: Results from a Population-Based Case-Control Study in France (The WELCA Study) (2022)

Circadian rhythm disruption due to night shift work and/or sleep disorders is associated with negative health outcomes including cancer. There is only scant evidence of an association with lung cancer, unlike breast and prostate cancer. We explore the role of sleep disorders and night shift work in lung cancer risk among women in a population-based case-control study, including 716 lung cancer cases and 758 controls. Multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) associated with sleep duration per day (<7 h, 7−7.9 h, ≥8 h), a summary index of sleep disorders, chronotype, and night shift work exposure metrics. When compared to women with an average sleep duration of 7−7.9 h per day, the OR was 1.39 (95% CI 1.04−1.86) in long sleepers (≥8 h) and 1.16 (95% CI 0.86−1.56) in short sleepers (<7 h). Overall, lung cancer was not associated with the sleep disorder index, nor with night shift work, regardless of the duration of night work or the frequency of night shifts. However, elevated OR associated with the sleep disorder index were found in the subgroup of current smokers. The U-shaped association of lung cancer with sleep duration was more particularly pronounced among women who worked at night ≥5 years. Our findings suggested that sleep patterns are associated with lung cancer risk in women with a potential modifying effect by night shift work duration or tobacco smoking.
Podcasting as an Effective Pedagogy for Teaching Chemistry During the COVID-19 Pandemic and Beyond (2022)

The COVID-19 pandemic has forced all educational institutions worldwide to switch their active routine to ONLINE. With students attending classes virtually, a number of problems arose including the absence of social interaction and the imposed difficulty of digesting the materials of different courses, especially for those with a scientific background. General chemistry (GC), as an introductory course, is usually registered by students from different backgrounds, including Science, Engineering, and Agriculture. At the United Arab Emirates University, the second level of GC (GCII) is more focused on problem-solving as related to various topics. With the absence of face-to-face experience because of the COVID-19 circumstances, students’ understanding of the chemical concepts and implementing that in problem-solving has become a challenge. The current work investigates the effect of using professionally-made podcasts of GCII on the extent of understanding of students registered for this course during the period of 2020-2020 over a course of four semesters. The results of surveying the usage and feedback of students engaged in this experiment are outlined. Conclusively, this pedagogy is fully supported by most of the students who regard it as a suitable alternative to face-to-face settings.