gebhart/patrepeval huggingface dataset:
Clinical Features of Immune Myopathies with Perimysial Pathology (IMPP) (PD6.009) (2012)

Objective: To characterize clinical and laboratory features of immune myopathies with perimysial pathology (IMPP). Background Perimysial pathology is a common feature of immune myopathies with Jo-1 antibodies. Myopathies with selectively high aldolase frequently have perimysial myopathology. We studied clinical and laboratory features of acquired syndromes with associated perimysial myopathology. Design/Methods: Retrospective review of records from 50 IMPP patients evaluated and treated at Washington University in St Louis between 1991 and 2011. Results: Epidemiologic: Median onset age was 44 years; Females were 66%; Caucasian 90%. Common clinical features included myalgias, rash, weakness, arthralgias, dysphagia and interstitial lung disease (ILD). Weakness was always proximal more than distal; In 75% both proximal and distal muscles were affected. No patient had only distal weakness. Patients carried clinical diagnoses of dermatomyositis or polymyositis. Median creatine kinase and aldolase values (IU/L) were 170 and 13.1. The most common myositis-specific antibody was Jo-1. All patients improved after immunomodulatory therapy, although medications in addition to corticosteroids were used in a majority due to incomplete response or side effects. Median post-treatment creatine kinase and aldolase levels were 47 and 5.2. Conclusions: IMPP are acquired, probably immune, multisystem syndromes that involve muscle, especially connective tissue, skin, gastrointestinal systems, lungs and joints. Aldolase is often selectively elevated with normal CK. IMPP syndromes can present clinically as either dermatomyositis or polymyositis. Over time, ILD may cause considerable morbidity. ILD should be monitored for in patients with IMPP myopathology. Myopathology may distinguish IMPP syndromes from other forms of dermatomyositis, such as those with vascular pathology, that are not commonly associated with ILD. IMPP syndromes commonly improve with immunomodulatory therapy, including corticosteroids and other drugs. Pathologic involvement of connective tissue in IMPP syndromes may explain their multisystem nature. Disclosure: Dr. Bucelli has nothing to disclose. Dr. Pestronk has received personal compensation or activities with Athena Diagnostics.Dr. Pestronk has received (royalty or license fee or contractual rights) payments from Athena Diagnostics.Dr. Pestronk holds stock and/or stock options in Johnson & Johnson.Dr. Pestronk has received research support from Knopp, ISIS, Sanofi-Aventis, and Prosensa.
Perceived stress and telomere length: A systematic review, meta-analysis, and methodologic considerations for advancing the field (2016)

Our analysis finds a very small, statistically significant relationship between increased PS (as measured over the past month) and decreased TL that may reflect publication bias, although fully parsing the effects of publication bias from other sample-size correlates is challenging, as discussed. The association may be stronger with known major stressors and is similar in magnitude to that noted between obesity and TL. All included studies used single measures of short-term stress; the literature suggests long-term chronic stress may have a larger cumulative effect. Future research should assess for potential confounders and use longitudinal, multidimensional models of stress.
Outage capacity of bidirectional relaying in cognitive relay networks (2010)

This article studies the outage capacity of bidirectional relaying using Decode and Forward (DF) in cognitive relay networks. We consider a communication system where two sources attempt to exchange their messages through a set of cognitive relay nodes. Only relays with successful decoding and spectrum acquisition are allowed to participate in the broadcast phase (BC). We consider two schemes for selecting the relays in the BC phase. In the first scheme, successfully decoding at least one of the two signals allows a relay to participate, while the second scheme requires successful decoding of both signals for a relay to participate. Simulation results illustrate the performance advantage of the first scheme for low SNR values. Furthermore, we use high SNR approximations in deriving closed from expressions for the outage capacity.
Models predicting survival to guide treatment decision-making in newly diagnosed primary non-metastatic prostate cancer: a systematic review (2019)

Few long-term prognostic models exist to inform decision-making at diagnosis of non-metastatic prostate cancer. Improved models are required to inform management and avoid undertreatment and overtreatment of non-metastatic prostate cancer.
Bronchioalveolar Carcinoma: Emphasis on Localized Lesions (1989)

Although well defined pathologically, alveolar cell carcinoma can be difficult to diagnose because of its many clinical presentations. In a retrospective study of 45 cases, we reviewed the radiologic, pathologic, and clinical features of this neoplasm. Forty-one patients had a single peripheral mass that measured between 8 mm and 7 cm. Three patients had multiple nodules, and one had diffuse involvement of the right lung. Other prominent radiologic features included air bronchograms in eight cases, a "tail sign" in ten cases, and universal absence of calcifications. Pathologic examination showed an associated scar in 12 patients. There was a relatively high frequency (16%) of metachronous malignancies, including two osteosarcomas, three basal cell carcinomas, and one case each of chronic lymphocytic leukemia and thymoma. All but one of the associated tumors were diagnosed six months to two years before the diagnosis of alveolar cell carcinoma.
Cardiac effects of halofantrine in children suffering from acute uncomplicated falciparum malaria (1998)

The cardiac effects of halofantrine were assessed in 42 children with acute symptomatic uncomplicated Plasmodium falciparum malaria by electrocardiographic (ECG) and clinical monitoring over a period of 14 d. The children were treated with oral halofantrine 8 mg/kg body weight every 6 h for 3 doses. There was significant prolongation of the P-R interval (compared with the pre-treatment value) only at 8 h after drug administration. However, first degree auriculoventricular (AV) block occurred in 2 children at 8 h or 8 and 48 h, and second degree AV block in another child at 48 h. There was significant prolongation of the Q-Tc interval at 8, 16, 24, 48 and 72 h after treatment; the proportions of children with Q-Tc interval > 0.44 s were also significantly higher at all these times except 72 h. Rhythm disturbance was rare. There was no significant ECG change at 168 or 336 h. Despite the ECG abnormalities, there was no clinical symptom. These findings indicate that, in children, the currently recommended dose of halofantrine for the treatment of falciparum malaria may produce serious cardiac side effects.
HCV Can Now Be Cultured (2005)

Research on hepatitis C virus (HCV) infection has been hampered by the inability to culture HCV in vitro. Three research groups (two of them overlapping) recently achieved this long-sought goal.

Wakita and colleagues transfected RNA containing the full-length genome of the JFH1 strain of HCV into a human hepatoma cell line (Huh7). They subsequently recovered secreted viral particles that exhibited biophysical and microscopic features …
Temperature dependence of the field induced magnetic form factor of CeSn3 (1979)

Polarized neutron scattering techniques have been used to study the spatial distribution and temperature dependence of the magnetization induced in a single crystal of CeSn3 by a magnetic field of 42.5 kG. We find that in the 300–40 K temperature range the measured form factor is in good agreement with the free ion 4f magnetic form factor of Ce3+. Below 40 K large deviations from a 4f magnetic form factor were observed. A satisfactory fit to the data below 40 K can be obtained by assuming that the induced magnetization contains a large component of 5d electronic character of eg symmetry.
Batchelder, Laurence • 1906–1990 (1990)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Stanley L. Ehrlich, Daniel W. Martin; Batchelder, Laurence • 1906–1990. J Acoust Soc Am 1 December 1990; 88 (6): 2899. https://doi.org/10.1121/1.399651 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Atomic force microscope study of three-dimensional nanostructure sidewalls (2007)

Next generation planar and non-planar complementary metal oxide semiconductor (CMOS) structures are three-dimensional nanostructures with multi-layer stacks that can contain films thinner than ten atomic layers. The high resolution of transmission electron microscopy (TEM) is typically chosen for studying properties of these stacks such as film thickness, interface and interfacial roughness. However, TEM sample preparation is time-consuming and destructive, and TEM analysis is expensive and can provide problematic results for surface and interface roughness. Therefore, in this paper, we present the use of direct measurements of sidewall surface structures by conventional atomic force microscopy (AFM) as an alternative or complementary method for studying multi-layer film stacks and as the preferred method for studying FinFET sidewall surface roughness. In addition to these semiconductor device applications, this AFM sidewall measurement technique could be used for other three-dimensional nanostructures.
Are we underestimating the potential for cardiotoxicity related to immune checkpoint inhibitors? (2020)

Abstract
Possible Medication-Resistant Deficits in Adult ADHD (2014)

There may be persistent cognitive impairments in adult ADHD despite medication. In addition, the benefit of stimulants seems reduced under cognitive fatigue.
Simple Substrate Feeding Rate Control Mechanism for Optimizing the Steady State Productivity of a Class of Continuous Fermentation Processes (1997)

Abstract This paper considers the problem of optimizing the productivity of a class of continuous fermentation processes which is described by an unstructured fermentation process model. By applying the first principle known by biotechnologists, for a prefixed dilution rate, we develop a simple substrate feeding rate control mechanism for optimizing the steady state productivity without knowing some of the process' parameters. Furthermore, we also show that this simple control law is robust against measurement noise and the variation of process' parameters.
MYC regulation of a “poor-prognosis” metastatic cancer cell state (2010)

Gene expression signatures are used in the clinic as prognostic tools to determine the risk of individual patients with localized breast tumors developing distant metastasis. We lack a clear understanding, however, of whether these correlative biomarkers link to a common biological network that regulates metastasis. We find that the c-MYC oncoprotein coordinately regulates the expression of 13 different "poor-outcome" cancer signatures. In addition, functional inactivation of MYC in human breast cancer cells specifically inhibits distant metastasis in vivo and invasive behavior in vitro of these cells. These results suggest that MYC oncogene activity (as marked by "poor-prognosis" signature expression) may be necessary for the translocation of poor-outcome human breast tumors to distant sites.
FOUR ASPECTS OF RELEVANCE IN SHARING LOCATION-BASED MEDIA: CONTENT, TIME, LOCATION AND NETWORK (2011)

Sharing information via internet is popular but the key problem is how to find relevant information. Two new features are becoming more popular: location and the social network of the user. We hypothesize that the relevance of data is defined by four aspects: content, time, location, and user network. We study how the location aspect is used in a media-sharing service called MOPSI.
STATUS OF THE HIGH CURRENT PERMANENT MAGNET 2.45GHZ ECR ION SOURCE AT PEKING UNIVERSITY (2010)

Several compact 2.45 GHz Electron Cyclotron Resonance Ion Sources (ECRISs) have been developed at Peking University for ion implantation [1], Separated Function Radio Frequency Quadrupole project (SFRFQ)[2] and for the Peking University Neutron Imaging FaciliTY project (PKUNIFTY) [3]. Studies on 2.45 GHz ECR ion sources are concentrated on methods of microwave coupling and microwave window design, magnetic field generation and configuration, as well as the extraction electrodes structure. Investigation also covers the influence of the size of plasma chamber on the discharge efficiency and species factor. Up to now, our sources have produced 25 mA of O ion, 40 mA of He ion, 10 mA of N ion, 100 mA of H ions and 83 mA of D ions, respectively.
Interconversion of CN and CNH2ligands: electrosynthesis and X-ray crystallographic structures of trans-[W(CNH2)Cl(dppe)2] and trans-[W(CNH2)Cl(dppe)2][BF4](dppe = Ph2PCH2CH2PPh2): aminocarbyne (C–NH2) or iminomethylenium (CNH2+) ligands? (1994)

Electrochemical reduction of trans-[W(CN)Cl(dppe)2] in the prsence of phenol gives trans-[W(CNH2)Cl(dppe)2]3, which can be oxidised electrochemically or chemically to the paramagnetic cation trans-[W(CNH2)Cl(dppe)2]+4; X-ray crystallographic analyses of 3 and 4[BF4] suggest that the CNH2 group at both the 18 and 17e W-centres is best described as iminomethylenium (CNH2+); 3 and the deutero-complex trans-[W(CND2)Cl(dppe)2] reduce azobenzene with regeneration of the parent cyanide, the former giving hydrazobenzene and latter PhNDNDPh, suggesting that the CNH(D)2 complexes can behave as 2H(D) atom transfer reagents.
Evaluation of delphinidin as a storage medium for avulsed teeth (2023)

Within the limits of this study, DP preserved the viability and suppressed the inflammatory response of periodontal ligament cells. These findings suggest that DP could be promising for preservation of avulsed teeth.
24: A COMPUTATIONAL MODEL TO PROFILE CYTOKINE NETWORKS MEDIATING ACUTE REJECTION AFTER COMPOSITE TISSUE ALLOTRANSPLANTATION (2010)

Plenary Paper Sessions: Scientific Session 3 - Developmental Biology, Tissue Engineering, Tumor Immunology/Cancer Biology
Synthesis and Characterization of a New Hydroquinone Derivative: Disodium <i>p</i>-Phenylene Diisostearyl Diphosphate (2015)

A novel amphiphilic hydroquinone derivative having a C18 alkyl chain phosphate attached to the hydroquinone (HQ) moiety was chemically synthesized. The thermal stability, distribution between organic and aqueous phases, and in vitro skin permeability were evaluated. This HQ derivative was identified as disodium p-phenylene diisostearyl diphosphate (HQ-2P2IS) by UV, infrared, mass, and nuclear magnetic resonance spectroscopies. Product HQ-2P2IS was obtained in good yield (56%), and it exhibited satisfactory stability in neutral solution, comparable to that of HQ. Its skin permeability was also higher than that of HQ. HQ-2P2IS is susceptible to enzymatic hydrolysis by tissue phosphatase, which releases HQ in the skin tissues. Thus, these characteristics indicate that the novel hydroquinone derivative presented herein, i.e., HQ-2P2IS, may serve as an effective pro-hydroquinone for skin care applications.
KEGG orthology-based annotation of the predicted proteome of Acropora digitifera: ZoophyteBase - an open access and searchable database of a coral genome (2013)

We advocate that providing annotation in an open-access searchable database available to the public domain will give an unprecedented foundation to interrogate the fundamental molecular structure and interactions of coral symbiosis and allow critical questions to be addressed at the genomic level based on combined aspects of evolutionary, developmental, metabolic, and environmental perspectives.
Analysis of sorbitan ester surfactants. Part I: High performance liquid chromatography (1994)

Abstract Sorbitan ester surfactants are very complicated mixtures. An improved and simple reversed phase high performance liquid chroma tographic (HPLC) method employing a C 18 column has been developed for the rapid separation of sorbitan ester surfactants and the quantitative determination of the distribution of sorbitan mono‐, di‐, tri‐, and tetraester fractions. The sorbitan ester distribution of the six Span and Arlacel surfactants studied was calculated using relative response factors obtained from analysis of pure glycerides of fatty acids. The effects of mobile phase composition on the accuracy and reliability of the distribution values calculated for the sorbitan esters were investigated.
Cadherin-5 redistribution at sites of TNF-α and IFN-γ-induced permeability in mesenteric venules (1999)

The response of the endothelial permeability barrier in microvascular networks of the rat mesentery to perfused immune inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) was examined. TNF-alpha (12.5 U/ml) treatment did not change albumin permeability, but in combination with IFN-gamma (20 U/ml), there was a marked increase in the number of sites of extravascular albumin in postcapillary venules. Endothelial integrity was characterized by cadherin-5 immunoreactivity, which was localized to the continuous intercellular junctions of endothelium in arterioles, capillaries, and venules. Perfusion with the combined cytokines showed that the increased albumin permeability was dose dependent and correlated with the focal disorganization of cadherin-5 at intercellular junctions of venular endothelium. No correlation was found between the increase in albumin permeability and the localization of intravascular leukocytes or extravascular mast cells. These results show that the combination of TNF-alpha and IFN-gamma induces an endothelial phenotype with focal loss of cadherin-5 intercellular adhesion, which, in part, facilitates passage of blood macromolecules and cells to the interstitium.
PiggyBac transposon vectors: the tools of the human gene encoding. (2016)

A transposon is a DNA segment, which is able to change its relative position within the entire genome of a cell. The piggyBac (PB) transposon is a movable genetic element that efficiently transposes between vectors and chromosomes through a "cut-and-paste" mechanism. During transposition, the PB transposase recognizes transposon-specific inverted terminal repeats (ITRs) sequences located on both ends of the transposon vector and eight efficiently moves the contents from its original positions and efficiently integrates them into TTAA chromosomal sites. PB has drawn much attention because of its transposition efficiency, safety and stability. Due to its priorities, PB can be used as a new genetic vehicle, a new tool for oncogene screening and a new method for gene therapy. PB has created a new outlook for human gene encoding.
Jojoba wax: Its esters and some of its minor components (1994)

Abstract A lack of reliability in the usual determinations of fatty acids and fatty alcohols of jojoba wax prompted us to propose an original method of hydrolysis and extraction, making it possible to better determine the composition of fatty acids and alcohols of the wax. High‐performance liquid chromatography fractionation of the wax allowed isolation of four main classes of esters (which differed by their partition number). The detailed study of these ester classes emphasized the way acids and alcohols are connected, and fourteen distinct esters were thus identified. Some triacylglycerols, free fatty alcohols and other minor components of jojoba wax were found and quantitated. Seven sterols were identified, four for the first time.
Measurement of diffusion and random motion effects with fast magnetic resonance imaging (1990)

In fast MR imaging with a steady-state free precession (SSFP) pulse sequence the coherent signal that forms just before each rf pulse depends entirely on echoes from previous pulses. When moderate strength field gradient pulses are applied, this signal is very sensitive to random motions such as diffusion. A theoretical analysis of the full effects of diffusion in SSFP imaging is in good agreement with preliminary experimental results in a water phantom, but a previously used approximation does not adequately account for the qualitative or quantitative features of these effects.
Joint estimation of center of gravity position and mass for the front and rear independently driven electric vehicle with payload in the start stage (2016)

This paper proposes a parameter estimator for four-wheel-independently driven electric (4 WID) vehicle with in-wheel motors. The mass and location of payload have great impacts on the stability and maneuverability of lightweight vehicles (LWVs). Fast, effective and real-time parameter estimator can make the existing controller adjust the changed parameter caused by additional payload. The proposed estimation method includes three parts with two calculation methods: the estimation of the angular acceleration of wheels, the vertical forces of tires, the vehicle parameter with payload, and the methods of Kalman Filtering (KF) and the recursive least squares method with a variable forgetting factor(RLS-VFF). The prototype of 4 WIDs LWV is the electric ground vehicle which driving torques can be controlled independently by four in-wheel motors. The simulation result is satisfied and the proposed estimator can be used to estimate the vehicle parameters.
Resurgence of diffractive optics in imaging, sensing, and inferencing (2022)

Traditional refractive lenses are bulky owing to their curvature. Flat diffractive lenses can overcome this difficulty, but traditional diffractive optics have limited reach, primarily due to chromaticity. Recently, we have shown that by treating the “imaging” phenomenon as simply information transfer from the object to the image plane, the spatial distribution of the phase in the focal plane can be an arbitrary function. Using this concept, we have shown that allowing the phase in the image plane of a flat lens to be a free parameter enables imaging properties of unprecedented versatility in flat, multilevel diffractive lenses (MDLs). Our research group has demonstrated multi-level diffraction lenses in multiple high performance categories: unchromatic lenses with dramatically improved operating bandwidths, high NA and large aperture sizes, and extreme depth of focus.Furthermore, these can be combined with advanced machine-learning algorithms to enhance inferencing.
Metformin-Induced Vitamin B12 Deficiency Presenting as a Peripheral Neuropathy (2010)

Chronic metformin use results in vitamin B12 deficiency in 30% of patients. Exhaustion of vitamin B12 stores usually occurs after twelve to fifteen years of absolute vitamin B12 deficiency. Metformin has been available in the United States for approximately fifteen years. Vitamin B12 deficiency, which may present without anemia and as a peripheral neuropathy, is often misdiagnosed as diabetic neuropathy, although the clinical findings are usually different. Failure to diagnose the cause of the neuropathy will result in progression of central and/or peripheral neuronal damage which can be arrested but not reversed with vitamin B12 replacement. To my knowledge, this is the first report of metformin-induced vitamin B12 deficiency causing neuropathy.
Disinfection by-products in drinking water : current issues (1999)

DBP formation and occurrence in treatment and distribution advances in analysis and monitoring standards and regulation balancing chemical and microbiological risk control of DBPs concluding remarks.