gebhart/patrepeval huggingface dataset:
Temporal Regular Path Queries (2021)

In the last decade, substantial progress has been made towards standardizing the syntax of graph query languages, and towards understanding their semantics and complexity of evaluation. In this paper, we consider temporal property graphs (TPGs) and propose temporal regular path queries (TRPQs) that incorporate time into TPG navigation. Starting with design principles, we propose a natural syntactic extension of the MATCH clause of popular graph query languages. We then formally present the semantics of TRPQs, and study the complexity of their evaluation. We show that TRPQs can be evaluated in polynomial time if TPGs are time-stamped with time points, and identify fragments of the TRPQ language that admit efficient evaluation over a more succinct interval-annotated representation. Finally, we implement a fragment of the language in a state-of-the-art dataflow framework, and experimentally demonstrate that TRPQ can be evaluated efficiently.
Sex Differences and Regulatory Actions of Estrogen in Cardiovascular System (2021)

Great progress has been made in the understanding of the pathophysiology of cardiovascular diseases (CVDs), and this has improved the prevention and prognosis of CVDs. However, while sex differences in CVDs have been well documented and studied for decades, their full extent remains unclear. Results of the latest clinical studies provide strong evidence of sex differences in the efficacy of drug treatment for heart failure, thereby possibly providing new mechanistic insights into sex differences in CVDs. In this review, we discuss the significance of sex differences, as rediscovered by recent studies, in the pathogenesis of CVDs. First, we provide an overview of the results of clinical trials to date regarding sex differences and hormone replacement therapy. Then, we discuss the role of sex differences in the maintenance and disruption of cardiovascular tissue homeostasis.
Polypeptides. XLV. Structure-function studies in the .beta.-corticotropin series (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolypeptides. XLV. Structure-function studies in the .beta.-corticotropin seriesKlaus Hofmann, Rudolf Andreatta, Hans Bohn, and Luis MoroderCite this: J. Med. Chem. 1970, 13, 3, 339–345Publication Date (Print):May 1, 1970Publication History Published online1 May 2002Published inissue 1 May 1970https://doi.org/10.1021/jm00297a001RIGHTS & PERMISSIONSArticle Views40Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
A Case of the Unusual Metastases to the Inguinal and Para-Aortic Lymph Nodes from Hepatocellar Carcinoma (2005)

肝細胞癌に対して2回の切除術と異時性に出現した鼠径部と傍大動脈リンパ節転移を切除しえた, まれな進展形式を呈した肝細胞癌切除例を経験したので報告する. 症例は69歳の男性で, 1980年胃癌手術時の輸血によりC型肝炎を発症した. 1995年肝細胞癌に対して肝S6切除術を施行し, 以後再発肝細胞癌に対して2度TAEを施行した. 2000年1月右鼠径部腫瘤に対して摘出術を施行した. 組織学的に肝細胞癌のリンパ節転移と診断された. 他に肝外転移巣なく同年3月右葉切除術を施行した. 腫瘍マーカーは正常化し経過観察していた. 3年後の2003年6月超音波検査で傍大動脈にリンパ節腫脹を指摘され, 腫瘍マーカーも上昇しており, 同年8月摘出術を施行した. 組織学的に肝細胞癌のリンパ節転移と診断された. 術後, 腫瘍マーカーは正常化し, 現在, 初回手術より9年, 無再発生存中である.
A unified approach to configuration-based dynamic analysis of quadcopters for optimal stability (2017)

A special type of rotary-wing Unmanned Aerial Vehicles (UAV), called Quadcopter have prevailed to the civilian use for the past decade. They have gained significant amount of attention within the UAV community for their redundancy and ease of control, despite the fact that they fall under an under-actuated system category. They come in a variety of configurations. The “+” and “x” configurations were introduced first. Literature pertinent to these two configurations is vast. However, in this paper, we define 6 additional possible configurations for a Quadcopter that can be built under either “+” or “x” setup. These configurations can be achieved by changing the angle that the axis of rotation for rotors make with the main body, i.e., fuselage. This would also change the location of the COM with respect to the propellers which can add to the overall stability. A comprehensive dynamic model for all these configurations is developed for the first time. The overall stability for these configurations are addressed. In particular, it is shown that one configuration can lead to the most statically-stable platform by adopting damping motion in Roll/Pitch/Yaw, which is described for the first time to the best of our knowledge.
ChemInform Abstract: A Synthesis of Homochiral 1,5‐Dialkyl‐1,5‐diamino‐3‐oxapentanes. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
TORUS concept machines: pre-prototyping design assessment for two major topologies (2002)

Two different external-rotor-internal-stator TORUS type axial flux PM machines can be derived based on the direction of the flux. In the first type of the TORUS machine, magnet driven flux enters the stator and travels circumferentially along the stator core while, in the second type, the flux enters the stator and travels axially along the machine axis of rotation. The major differences between the two topologies are the direction of the magnet driven flux, the winding arrangement and the thickness of the stator yoke. In this paper, the sizing equations are derived for both types of TORUS machines. Based on the sizing analysis, optimum design is achieved for minimum ripple torque and maximum torque density. Furthermore, finite element analysis (FEA) of both TORUS structures are investigated to get an insight in 3D field distribution, flux directions and paths in different parts of the machines for different load conditions. Minimization of the cogging and ripple torque components of the TORUS concept machines are displayed using 3D FEA for the insight in pulsating torques, ripple torques and cogging torques. Finally the comparison of the TORUS topologies are made in terms of flux densities, cogging and ripple torques and the results are illustrated in the paper.
Can occult metastases be Treated by radioimmunotherapy? (1997)

BACKGROUND Tumor lesions in the millimeter (mm) range may escape detection with nuclear medicine imaging methods (including single photon emission computed tomography [SPECT]) using radiolabeled monoclonal antibodies (MoAbs). We hypothesized that these lesions still could receive a potentially therapeutic radiation absorbed dose, and therefore should be treated, despite the lack of detection. METHODS To simulate this situation, 2-mm beads (0.004 mL) containing ∼1.15 μCi of iodine-131 (131I) were used. The beads were placed centrally in a 1200-mL liver phantom containing ∼3 mCi of 131I. The resultant activity concentration on the beads was ∼288 μCi/mL compared with ∼2.5 μCi/mL in the phantom, corresponding to a maximum tumor uptake of ∼0.3% injected dose per gram (%ID/g) if 100 mCi of 131I-labeled immunoglobulin G were administered. The phantom, containing the beads, was imaged by both planar and SPECT techniques at hypothetical Day 1 (time of maximum tumor uptake) and at hypothetical Day 7 to examine the improved target-to-nontarget ratio over time. In addition to imaging the beads, the radiation absorbed dose to the simulated lesions from the beta component emissions of 131I was calculated using absorbed fractions based on Berger's point kernels. RESULTS Regardless of the conditions used, the beads could not be observed by either planar or SPECT imaging. However, the radiation-absorbed dose to the simulated lesion was calculated to be as high as ∼6200 centigray (cGy), with an average dose rate of ∼89.5 cGy/hour. CONCLUSIONS This simulation demonstrates that a relatively high absorbed dose and dose rate can be delivered to mm-sized lesions not observed by conventional nuclear imaging methods, and that these lesions should be considered for radioimmunotherapy with 131I MoAbs. However, for micrometastases of <1 mm, other radionuclides with shorter path length β particles than 131I, Auger electrons, or α particles should be considered. Cancer 1997; 80:2656-9. © 1997 American Cancer Society.
Functionalized nanoporous silicon for extraction of Sc from a leach solution (2022)

Production of scandium (Sc) is a complicated process largely because the Sc concentration in ores is typically low in comparison to other types of metals. Therefore, typical extraction processes, such as solvent extraction and precipitation, that are used for separation and purification of leach liquors are inefficient. Adsorption/desorption is a good alternative method for extraction, but it is challenging to prepare affordable adsorbents with high stability, good selectivity, and high adsorption capacity. Most Sc sources are currently unexploited, and new, efficient, and environmentally sustainable methods for Sc extraction are needed. In the present study, bisphosphonates (BPs) immobilized on the surface of nanoporous silicon were used as metal ion chelators. Thermal carbonization was used to passivate the porous silicon surfaces with silicon carbide, on which the BP molecules were grafted. The BP grafted thermally carbonized porous silicon (BP-TCPSi) was used to extract Sc from a leach solution of Sc ore obtained from Rautalampi, Finland. First, Sc was leached from the ore using sulfuric acid. An oxidative precipitation method was employed to reduce the concentrations of the interfering metal ions; this treatment decreased the Fe, Ti, Al, and Mn concentrations by 99 ± 2%, 100 ± 14%, 35 ± 1%, and 76 ± 2%, respectively, while only 12 ± 1% of Sc was lost. The selectivity of BP-TCPSi was studied in a flow-through setup to adsorb Sc from the treated leach solution; then, in a two-step desorption process, Sc was separated from the other metal ions with a separation factor of 440 ± 13. The reusability of BP-TCPSi was examined in a flow-through setup with 10 adsorption/desorption cycles using a treated leach solution showing good stability of the adsorbent. The developed method provides a fast and convenient way to extract, purify, and enrich Sc with total recovery of 69 ± 1% in one cycle of adsorption/desorption of Sc from the leach solution with a low Sc concentration and a relatively high concentration of the other metal ions.
Targeting inflammasome/IL-1 pathways for cancer immunotherapy (2016)

The inflammatory microenvironment has been shown to play important roles in various stages of tumor development including initiation, growth, and metastasis. The inflammasome is a critical innate immune pathway for the production of active IL-1β, a potent inflammatory cytokine. Although inflammasomes are essential for host defense against pathogens and contribute to autoimmune diseases, their role in tumor progression remains controversial. Here, our results demonstrate that the inflammasome and IL-1β pathway promoted tumor growth and metastasis in animal and human breast cancer models. We found that tumor progression was associated with the activation of inflammasome and elevated levels of IL-1β at primary and metastatic sites. Mice deficient for inflammasome components exhibited significantly reduced tumor growth and lung metastasis. Furthermore, inflammasome activation promoted the infiltration of myeloid cells such as myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) into tumor microenvironments. Importantly, blocking IL-1R with IL-1R antagonist (IL-Ra) inhibited tumor growth and metastasis accompanied by decreased myeloid cell accumulation. Our results suggest that targeting the inflammasome/IL-1 pathway in tumor microenvironments may provide a novel approach for the treatment of cancer.
Knee disorders in carpet and floor layers and painters. (1992)

In an evaluation of the effect of kneeling work on the knees, 168 actively working carpet and floor layers and 146 house painters were examined with the aid of a questionnaire, a clinical examination, and radiography. Reported knee pain, knee accidents, and treatment regimens for the knees were more common among the carpet and floor layers than among the painters. Radiographic changes of the tibiofemoral joint were noted equally in the two occupational groups, but osteophytes of the patella were more common among the carpet and floor layers than among the painters. In a multivariate analysis, the determinants of osteophytosis of the knee were age, occupation, knee accidents, and smoking, and osteophytosis may be due to more frequent workbreaks from kneeling postures among smoking workers. This study indicates that kneeling work increases the risk of knee disorders and such radiographic changes that might be an initial sign of knee degeneration.
Facile Preparation of Lightweight Microcellular Polyetherimide/Graphene Composite Foams for Electromagnetic Interference Shielding (2013)

We report a facile approach to produce lightweight microcellular polyetherimide (PEI)/graphene nanocomposite foams with a density of about 0.3 g/cm3 by a phase separation process. It was observed that the strong extensional flow generated during cell growth induced the enrichment and orientation of graphene on cell walls. This action decreased the electrical conductivity percolation from 0.21 vol % for PEI/graphene nanocomposite to 0.18 vol % for PEI/graphene foam. Furthermore, the foaming process significantly increased the specific electromagnetic interference (EMI) shielding effectiveness from 17 to 44 dB/(g/cm3). In addition, PEI/graphene nanocomposite foams possessed low thermal conductivity of 0.065-0.037 W/m·K even at 200 °C and high Young's modulus of 180-290 MPa.
Cryosurgery as a treatment for prostate carcinoma: results and complications. (1997)

These preliminary results demonstrate that cryosurgical ablation of the prostate is a viable treatment option for prostate carcinoma. In the authors' experience, ultrasound alone may not be adequate for monitoring the entire cryosurgical procedure. The authors found that temperature monitoring shortened their learning curve, enabled them to freeze prostate tissue more aggressively, and may have contributed to their overall success.
Development of CdTe nuclear radiation detectors for spectroscopy and imaging applications (2005)

CdTe nuclear radiation detectors were developed for spectroscopy and imaging applications. Detectors were fabricated in two different techniques in order to alleviate the poor hole charge transport property in CdTe semiconductor. The first type comprises an M-/spl pi/-n diode type detector fabricated by growing an n-type CdTe epitaxial layer on the p-like high resistivity CdTe crystal wafer. This detector is operated in a reverse bias mode, which allows us to apply high electric field on the detector without increasing the leakage current noise of the detector. The second type is a multi-electrode pixel type detector working on a small pixel effect. It has three electrodes in each pixel on one side and a common cathode on the opposite side. Performance of both types of detectors will be presented.
A Simple PCR Method for Rapid Genotype Analysis of Mycobacterium ulcerans (2000)

Two high-copy-number insertion sequences, IS2404 and IS2606, were recently identified in Mycobacterium ulcerans and were shown by Southern hybridization to possess restriction fragment length polymorphism between strains from different geographic origins. We have designed a simple genotyping method that captures these differences by PCR amplification of the region between adjacent copies of IS2404 and IS2606. We have called this system 2426 PCR. The method is rapid, reproducible, sensitive, and specific for M. ulcerans, and it has confirmed previous studies suggesting a clonal population structure of M. ulcerans within a geographic region. M. ulcerans isolates from Australia, Papua New Guinea, Malaysia, Surinam, Mexico, Japan, China, and several countries in Africa were easily differentiated based on an array of 4 to 14 PCR products ranging in size from 200 to 900 bp. Numerical analysis of the banding patterns suggested a close evolutionary link between M. ulcerans isolates from Africa and southeast Asia. The application of 2426 PCR to total DNA, extracted directly from M. ulcerans-infected tissue specimens without culture, demonstrated the sensitivity and specificity of this method and confirmed for the first time that both animal and human isolates from areas of endemicity in southeast Australia have the same genotype.
Acetate production from whey lactose using co-immobilized cells of homolactic and homoacetic bacteria in a fibrous-bed bioreactor (1998)

Acetate was produced from whey lactose in batch and fed-batch fermentations using co-immobilized cells of Clostridium formicoaceticum and Lactococcus lactis. The cells were immobilized in a spirally wound fibrous sheet packed in a 0.45-L column reactor, with liquid circulated through a 5-L stirred-tank fermentor. Industrial-grade nitrogen sources, including corn steep liquor, casein hydrolysate, and yeast hydrolysate, were studied as inexpensive nutrient supplements to whey permeate and acid whey. Supplementation with either 2.5% (v/v) corn steep liquor or 1.5 g/L casein hydrolysate was adequate for the cocultured fermentation. The overall acetic acid yield from lactose was 0.9 g/g, and the productivity was 0.25 g/(L h). Both lactate and acetate at high concentrations inhibited the homoacetic fermentation. To overcome these inhibitions, fed-batch fermentations were used to keep lactate concentration low and to adapt cells to high-concentration acetate. The final acetate concentration obtained in the fed-batch fermentation was 75 g/L, which was the highest acetate concentration ever produced by C. formicoaceticum. Even at this high acetate concentration, the overall productivity was 0.18 g/(L h) based on the total medium volume and 1.23 g/(L h) based on the fibrous-bed reactor volume. The cells isolated from the fibrous-bed bioreactor at the end of this study were more tolerant to acetic acid than the original culture used to seed the bioreactor, indicating that adaptation and natural selection of acetate-tolerant strains occurred. This cocultured fermentation process could be used to produce a low-cost acetate deicer from whey permeate and acid whey.
Fast Agglomeration of Ultrafine Hydrophobic Particles Using a High-Internal-Phase Emulsion Binder Comprising Permeable Hydrophobic Films (2017)

A novel hydrophobic binder consisting of tightly packed drops of aqueous salt solution, stabilized by thin films of oil, in the form of a high-internal-phase water-in-oil emulsion was used to agglomerate ultrafine hydrophobic particles in seconds to a size sufficient for their capture on a 150-μm screen. Almost complete recovery of the particles, extending from sizes of more than 100 μm to less than 500 nm, was achieved. Examination of the process revealed that the agglomeration appears to be governed primarily by the length scale of the thin oil films, on the order of 30 nm, and their ability to quickly and efficiently deliver organic liquid to the particles. Moreover, it appears that the hydrodynamic resistance that develops when a particle is driven toward an interface is reduced because of the permeability of the films. Water permeation driven by osmosis also appears to assist the transport of the particles toward the interface.
ChemInform Abstract: Transition‐Metal Free Highly Selective Aerobic Oxidation of Hindered 2‐Alkylindoles. (2015)

Abstract Highly complex 3‐oxoindolin‐2‐ylidene derivatives are synthesized through a one‐pot procedure starting by Ugi four‐component reaction followed by an aerobic oxidation reaction under metal‐free conditions with excellent regioselectivity.
Efficient Grain Boundary Suture by Low-Cost Tetra-ammonium Zinc Phthalocyanine for Stable Perovskite Solar Cells with Expanded Photoresponse (2018)

Defects within the grain boundaries (GBs) of halide perovskite films make fabrication of efficient and stable perovskite solar cells (PSCs) highly challenging. Here, a low-cost tetra-ammonium zinc phthalocyanine (ZnPc) was used to post-treat the MAPbI<sub>3</sub> (MA = CH<sub>3</sub>NH<sub>3</sub>) film. Two-dimensional (ZnPc)<sub>0.5</sub>MA <sub>n-1</sub>Pb <sub>n</sub>I<sub>3 n+1</sub> was successfully constructed within the GBs of MAPbI<sub>3</sub> film achieving a GBs suture for passivating the defects in GBs. Time-resolved photoluminescence showed that the modification increased the decay time from 44 to 57 ns indicating the passivation of GBs reduces trap-assisted recombination. The PSCs with modified perovskite exhibited increased photovoltage, and the best efficiency was improved up to 20.3%. More importantly, the long-term stability of the responding PSCs against humidity and heating was further improved unprecedentedly. Moreover, the modified MAPbI<sub>3</sub> films revealed a self-repairing capability under mild heating. This work provided a novel insight into ongoing fabrication of efficient and stable PSCs by the efficient GBs suture with low-cost phthalocyanine.
A short-lived nuclear phosphoprotein encoded by the human ets-2 proto-oncogene is stabilized by activation of protein kinase C. (1988)

The human ets-2 gene is a homolog of the v-ets oncogene of the E26 virus and codes for a 56-kilodalton nuclear protein. The ets-2 protein is phosphorylated and has a rapid turnover, with a half-life of 20 min. When human lymphocytic CEM cells were treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), the level of the ets-2 protein was quickly elevated 5- to 20-fold. This effect of TPA was mimicked by a synthetic diacylglycerol, 1-oleoyl-2-acetyl glycerol, and was blocked by the protein kinase C inhibitor H7, indicating that protein kinase C is involved in the induction. The increase in the ets-2 protein was due to stabilization of the protein, because the protein had a half-life of more than 2 h in the presence of TPA and the ets-2 mRNA level did not increase significantly upon TPA treatment. The protein synthesis inhibitor cycloheximide enhanced the effect of TPA on the ets-2 protein and could itself slow turnover of the protein. Properties of the ets-2 protein, such as nuclear localization, phosphorylation, rapid turnover, and response to protein kinase C, indicate that this protein belongs to a group of oncogene proteins which are generally thought to have regulatory functions in the nucleus (e.g., myc, fos, myb, and p53). Our results suggest that protein kinase C, either directly or indirectly, regulates the level of the ets-2 protein by posttranslational mechanisms.