gebhart/patrepeval huggingface dataset:
Extreme Environment Silicon Carbide Hybrid Temperature & Pressure Optical Sensors (2010)

This final report contains the main results from a 3-year program to further investigate the merits of SiC-based hybrid sensor designs for extreme environment measurements in gas turbines. The study is divided in three parts. Part 1 studies the material properties of SiC such as temporal response, refractive index change with temperature, and material thermal response reversibility. Sensor data from a combustion rig-test using this SiC sensor technology is analyzed and a robust distributed sensor network design is proposed. Part 2 of the study focuses on introducing redundancy in the sensor signal processing to provide improved temperature measurement robustness. In this regard, two distinct measurement methods emerge. A first method uses laser wavelength sensitivity of the SiC refractive index behavior and a second method that engages the Black-Body (BB) radiation of the SiC package. Part 3 of the program investigates a new way to measure pressure via a distance measurement technique that applies to hot objects including corrosive fluids.
Poster 245: Periarticular Local Infiltrative Anesthesia after Anterior Cruciate Ligament Reconstruction: A Comparison to Regional Adductor Canal Block with Matched Sub-Analysis (2022)

Objectives: There is a paucity of literature that directly compares postoperative pain control and hospital recovery after using periarticular local infiltrative anesthesia (LIA) or regional anesthesia with an adductor canal block (ACB) for ambulatory anterior cruciate ligament reconstruction (ACLR) surgery. Additional studies are needed to investigate the analgesic efficacy of both ACB and LIA in patients undergoing ACLR surgery with concomitant procedures. The purpose of this study is to compare postoperative pain and recovery after anterior cruciate ligament reconstruction (ACLR) in patients who received an adductor canal block (ACB) or periarticular local infiltrative anesthesia (LIA). Methods: Study Design: Retrospective comparison studyA retrospective review of a prospectively collected ACL registry was performed. Patients underwent ACLR at a single institution between January 2015 and September 2020 and received long-acting local anesthesia with a pre-operative ultrasound-guided ACB or peri-articular LIA after surgery. Visual Analog Scale (VAS) pain scores, milligram morphine equivalents (MME) consumed in the post-anesthesia care unit (PACU), and total hospital recovery time were compared. Univariate analysis was used to compare VAS pain and MME totals between overall groups and groups matched for age, sex, BMI, graft type, and meniscal treatment. A p-value &lt; 0.05 indicated statistical significance. Results: There were 265 knees (253 patients) included (LIA, 157 knees; ACB, 108 knees). Overall, VAS pain scores before hospital discharge (LIA 2.6 ± 1.5 vs. ACB 2.4 ± 1.4, p=0.334) and total MMEs were similar (LIA 17.6 ± 7.6 vs. ACB 18.5 ± 6.7 (MME), p=0.134). Total time to discharge also did not significantly differ (LIA 137.5 (IQR:116-178) vs. ACB 147 (IQR:123-183) (min), p=0.118). Matched sub-analysis (LIA and ACB, n=94) did not reveal significant differences in VAS pain before discharge (LIA 2.4 ± 1.4 vs ACB: 2.7 ± 1.5, p=0.122) or total MMEs (LIA 18.6 ± 6.7 vs. ACB 17.9 ± 7.1, p=0.532). Conclusions: The use of ACB or LIA resulted in similar pain levels and opioid consumption during early recovery after ACLR surgery.
Removal of Iron from Pyrite-Rich Coal Refuse by Calcination and Magnetic Separation for Hydrometallurgical Extraction of Rare Earth Elements (2023)

In the metallurgical extraction of rare earth elements (REEs), the ratio of contaminant ions to REEs in the leachate dictates the cost and operational efficiency of the downstream processes. The current study investigated the potential iron contamination removal from the feed to the hydrometallurgical process by calcination followed by magnetic separation. The 2.20 specific gravity sink fraction of Baker coal seam coarse refuse was pulverized to finer than 180 μm, calcined at various temperatures, and separated into magnetic and non-magnetic fractions using a wet high-intensity magnetic separator at different field strengths. The untreated feed, calcined products, and their subsequent magnetic and non-magnetic fractions were subjected to acid leaching tests with 1.2 M sulfuric acid at 75 °C and 1% w/v solids concentration. The recovery of light and heavy rare earth elements (LREEs and HREEs, respectively) along with the concentration of common contaminant ions (Al, Ca, and Fe) were measured as output variables. The weight percent of magnetic material was maximized at approximately 29% by calcination at a temperature of 400 °C. Magnetic removal of this fraction using a field strength of 1.15 Tesla resulted in the rejection of 81% of the iron. Leaching of the magnetic fraction provided significantly higher Fe recovery relative to untreated feed material and the non-magnetic fraction. The non-magnetic fraction was subsequently calcined at 600 °C to dehydroxylate the clays and released the REE minerals in the same manner as the treatment of the original coarse refuse material. A comparison of the leachate elemental concentrations resulting from the leaching of both the calcined non-magnetic and original coarse refuse showed only a slight reduction in the iron content from the non-magnetic material. This finding combined with the REE loss in the magnetic fraction resulted in the conclusion that the magnetic removal step was unfavorable.
Wavelength Transparency of All-Optical Packet Envelope Detection Circuit for RZ-Format Optical Packet Switching Applications (2009)

We present results of an extensive characterization of all-optical packet envelope detection circuit for packet switched networks. We experimentally demonstrated correct operation with return-to-zero-format data pulses at 10 and 40 Gb/s for a broad range of input wavelengths and power levels.
Retinal functional alterations in mice lacking intermediate filament proteins glial fibrillary acidic protein and vimentin (2015)

Vimentin (Vim) and glial fibrillary acidic protein (GFAP) are important components of the intermediate filament (IF) (or nanofilament) system of astroglial cells. We conducted full-field electroretinogram (ERG) recordings and found that whereas photoreceptor responses (a-wave) were normal in uninjured GFAP(-/-)Vim(-/-) mice, b-wave amplitudes were increased. Moreover, we found that Kir (inward rectifier K(+)) channel protein expression was reduced in the retinas of GFAP(-/-)Vim(-/-) mice and that Kir-mediated current amplitudes were lower in Müller glial cells isolated from these mice. Studies have shown that the IF system, in addition, is involved in the retinal response to injury and that attenuated Müller cell reactivity and reduced photoreceptor cell loss are observed in IF-deficient mice after experimental retinal detachment. We investigated whether the lack of IF proteins would affect cell survival in a retinal ischemia-reperfusion model. We found that although cell loss was induced in both genotypes, the number of surviving cells in the inner retina was lower in IF-deficient mice. Our findings thus show that the inability to produce GFAP and Vim affects normal retinal physiology and that the effect of IF deficiency on retinal cell survival differs, depending on the underlying pathologic condition.
P4‐219: Long‐term safety and tolerability of donepezil 23 mg in patients with moderate‐to‐severe Alzheimer's disease: An 18‐month analysis (2011)

In real-world clinical practice, pharmacological treatment of Alzheimer's disease (AD) tends to follow a prolonged course. It is, therefore, important that the safety/tolerability profile of new AD treatments, or new therapeutic doses of existing treatments, is assessed over the long-term, in order to provide additional guidance to treating physicians. A post-hoc analysis was conducted using data from a 24-week double-blind study (DBS) of donepezil 23 mg/day versus 10 mg/day in patients with moderate-to-severe AD (MMSE 0-20) and a subsequent 12-month, open-label extension (OLE) study of donepezil 23 mg/day. Data analyzed originated from patients who had been assigned to treatment with donepezil 23 mg/day in the DBS, who tolerated 24 weeks of donepezil 23 mg/day in the DBS, and who were subsequently included in the OLE safety population. Safety and tolerability were assessed across the full 18 months of the DBS and OLE by the incidence, severity, and relationship to study drug of treatment-emergent adverse events (TEAEs). A total of 570 patients met criteria for inclusion in the analyses; 423 patients (74.2%) completed the OLE and the average duration of treatment with donepezil 23 mg/day across the DBS and OLE was 16.21 months. Overall, 486 of the 570 patients (85.3%) experienced at least one TEAE; most of the patients with TEAEs (> 80%) experienced TEAEs of mild/moderate severity and in 38.7%, the TEAEs were considered unrelated to study drug. The most common TEAEs reported across the overall analysis population were decreased weight (13.9%), fall (12.1%) nausea (9.5%), and urinary-tract infection (UTI; 8.8%). Of the 570 patients analyzed, 68 (11.9%) discontinued treatment due to TEAEs; in 34 of these patients the TEAE leading to discontinuation was considered unrelated to study drug. Serious TEAEs were experienced by 93 of the 570 patients (16.3%); the most common were fall (1.6%) and UTI (1.6%). There were 14 deaths (2.5%), none of which were considered related to the study drug. Results from this post-hoc analysis indicate that treatment with donepezil 23 mg/day for up to 18 months appears to be safe and generally well tolerated in patients with moderate-to-severe AD.
Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependent (2021)

PI3Ks are important lipid kinases that produce phosphoinositides phosphorylated in position 3 of the inositol ring. There are three classes of PI3Ks: class I PI3Ks produce PIP3 at plasma membrane level. Although D. melanogaster and C. elegans have only one form of class I PI3K, vertebrates have four class I PI3Ks called isoforms despite being encoded by four different genes. Hence, duplication of these genes coincides with the acquisition of coordinated multi-organ development. Of the class I PI3Ks, PI3Kα and PI3Kβ, encoded by PIK3CA and PIK3CB, are ubiquitously expressed. They present similar putative protein domains and share PI(4,5)P2 lipid substrate specificity. Fifteen years after publication of their first isoform-selective pharmacological inhibitors and genetically engineered mouse models (GEMMs) that mimic their complete and specific pharmacological inhibition, we review the knowledge gathered in relation to the redundant and selective roles of PI3Kα and PI3Kβ. Recent data suggest that, further to their redundancy, they cooperate for the integration of organ-specific and context-specific signal cues, to orchestrate organ development, physiology, and disease. This knowledge reinforces the importance of isoform-selective inhibitors in clinical settings.
19. Renal extractions of endogenous and tritiated norepinephrine and epinephrine in patients with cardio-renal disorders and in healthy volunteers (1995)

Johansson, M.1; Rundqvist, B.2; Eisenhofer, G.4; Volmann, R.1; Jensen, G.3; Friberg, P.1 Author Information
Design, optimization and construction of an electric motor for an Electric Rear Wheel Drive unit application for a hybrid passenger car (2010)

An Electric Rear Wheel Drive -ERWD- unit is a cost effective solution for the electrification of passenger cars. While the conventional front-wheel transmission is kept, the ERWD unit provides electrical torque to the rear wheels and regenerative braking capabilities. In this article the design, optimization, construction and testing of an electric motor for such unit is presented. The experimental test results are compared to the FE simulation results from the design stage in order to validate the design tool.
Total assignments, including four aromatic residues, and sequence confirmation of the decapeptide tyrocidine A using difference double resonance. Qualitative nuclear overhauser effect criteria for beta turn and antiparallel beta-pleated sheet conformations. (1979)

The complete assignments of all the proton magnetic resonance signals from each NH-CalphaH-CbetaH2 moiety in a complex peptide containing several residues of the same type has not yet been achieved without specific or stereospecific isotopic enrichment. We report the sequencing and proton magnetic resonance spectral assignments, including those of 4 aromatic residues, of tyrocidine A, an analog of the decapeptide gramicidin S. Two complementary methods, proton-proton nuclear Overhauser enhancements and scalar decoupling, evaluated by two distinct forms of difference double resonance, were used. All chemical shifts, scalar coupling constants, and [1H:1H] nuclear Overhauser enhancements for the backbone protons are reported. The [1H:1H] nuclear Overhauser enhancements are consistent with tyrocidine A possessing a beta-I turn/beta-II' turn/antiparallel beta-pleated sheet conformation. In addition to the previously proposed nuclear Overhauser enhancement criteria for beta turns and antiparallel beta sheets, another criterion for identifying the antiparallel beta sheet is demonstrated; namely, the nuclear Overhauser enhancement between 2 CalphaH protons of the central resisdues, in this case the Phe7CalphaH and Orn2CalphaH.
Production of Electricity and Liquid Fuels with Low Carbon Footprint (2018)

Abstract Die Nutzung bestehender Kohlekraftwerke ermöglicht die Herstellung von Strom und flüssigen Kraftstoffen mit niedrigem Carbon Footprint. Drei verfahrenstechnische Prozessverbundvarianten werden miteinander verglichen. Im Kraftwerk wird Strom erzeugt und aus den Kraftwerksabgasen wird CO 2 gewonnen, das mit Wasserstoff zu flüssigen Kraftstoffen hydriert wird. H 2 wird durch Wasserelektrolyse oder Methanpyrolyse produziert. Gegenüber dem Vergleichsfall (Strom aus Kohlekraftwerk und Kraftstoffe aus einer Rohölraffinerie) lassen sich die CO 2 ‐Emissionen senken, wenn der Wasserstoff aus einer mit Windstrom betriebenen Elektrolyse oder aus einer Methanpyrolyse kommt.
Twisted-and-Coiled Actuators with Free Strokes Enable Soft Robots with Programmable Motions (2020)

Various actuators (e.g., pneumatics, cables, dielectric elastomers, etc.) have been utilized to actuate soft robots. Besides widely used actuators, a relatively new artificial muscle-twisted-and-coiled actuators (TCAs)-is promising for actuating centimeter-scale soft robots because they are low cost, have a large work density, and can be driven by electricity. However, existing works on TCA-actuated soft robots in general can only generate simple bending motion. The reason is that TCAs fabricated with conventional methods have to be preloaded to generate a large contraction, and thus cannot actuate soft robots properly. In this work, an upgraded technique is presented to fabricate TCAs that can deliver 48% free strokes (contraction without preloading). We first compare the static performance of TCAs with free strokes with conventional TCAs, and then characterize how will the fabrication parameters influence the TCAs' stroke and force capability. After that, we demonstrate that such TCAs can actuate centimeter-scale soft robots with programmable motions (gripping, twisting, and three-dimensional bending). Finally, we combine those motions to demonstrate a soft robotic arm that can perform a pick-and-place task. We expect that TCAs with free strokes can enable miniature soft robots with rich three-dimensional motions for both locomotion and manipulation. Because TCAs are electrically driven, we can also potentially develop untethered soft robots by carrying onboard batteries and control circuits.
Data from Oncogenic Herpesvirus HHV-8 Promotes Androgen-Independent Prostate Cancer Growth (2023)

&lt;div&gt;Abstract&lt;p&gt;Mechanisms underlying progression to androgen-independent prostate cancer following radical ablation therapy remain poorly defined. Although intraprostatic infections have been highlighted as potential cofactors, pathogen influences on pathways that support tumor regrowth are not known. To explore this provocative concept, we derived androgen-sensitive and -insensitive prostate epithelial cells persistently infected with human herpesvirus 8 (HHV-8), an oncogenic herpesvirus that has been detected in normal prostate epithelium, prostate adenocarcinoma, and biologic fluids of patients with prostate cancer, to explore its effects on transition to hormone-refractory disease. Strikingly, we found that HHV-8 infection of androgen-sensitive prostate cancer cells conferred the capacity for androgen-independent growth. This effect was associated with altered expression and transcriptional activity of the androgen receptor (AR). However, HHV-8 infection bypassed AR signaling by promoting enhancer of zeste homolog 2 (EZH2)–mediated epigenetic silencing of tumor-suppressor genes, including &lt;i&gt;MSMB&lt;/i&gt; and &lt;i&gt;DAB2IP&lt;/i&gt; that are often inactivated in advanced disease. Furthermore, we found that HHV-8 triggered epithelial-to-mesenchymal transition. Although HHV-8 has not been linked etiologically to prostate cancer, virologic outcomes revealed by our study provide mechanistic insight into how intraprostatic infections could constitute risk for progression to androgen-independent metastatic disease where EZH2 has been implicated. Taken together, our findings prompt further evaluations of the relationship between HHV-8 infections and risk of advanced prostate cancer. &lt;i&gt;Cancer Res; 73(18); 5695–708. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Postgranulomatous Anetoderma Associated With Takayasu's Arteritis in a Child (1987)

Takayasu's arteritis (TA) is a rare chronic inflammatory arteriopathy affecting mainly the aorta and its branches. Many skin manifestations have been reported in association with this disease. Pyoderma gangrenosum and subcutaneous inflammatory lesions of the leg are the most frequent. We studied a boy with TA in whom a papular rash of the trunk preceded the onset of vascular symptoms by many years. Histologically, the lesions were superficial and consisted of middermal noncaseating tuberculoid granulomas, which progressed to atrophy and anetoderma because of elastic network disruption. Granulomas were also found in synovial tissue but not in a temporal artery biopsy specimen, which showed only intimal hyperplasia. Our observations suggest that vascular and skin lesions with elastic tissue may both result from a common granulomatous hypersensitivity process.
Low-Stress Level PinUp Drillstring Optimizes Drilling of 20,000 ft. Slim-Hole in Southern Oklahoma (1999)

This paper was prepared for presentation at the 1999 SPE/IADC Drilling Conference held in Amsterdam, Holland, 9-11 March 1999.
1P1-C04 Development of robotic transportation system : Shopping support system collaborating with environmental cameras and mobile robots (2009)

The robotic transportation system for shopping assist has been developed. The system consists of a guidance robot, a cart robot, and environmental cameras. The guidance robot is an autonomous mobile robot with position localization function, the cart robot with a shopping basket can follow the guidance robot, and environmental cameras can detect the robots and human. Verification test has been performed in the test environment assumed for a food store. The guidance robot was able to guide a person to his/her desired place and the cart robot was able to carry the foods while following the person.
Opiate receptor modifications in the rat brain after chronic treatment with haloperidol and suipiride (1990)

Anatomical, electrophysiological and pharmacological data support the existence of a pronounced interaction between dopamine (DA) and opioids. In particular, chronic administration of DA antagonist drugs modifies opiate peptides and opiate receptors. In this paper we focused, by means of quantitative receptor autoradiography, on the modifications induced by chronic neuroleptic treatment, in patches versus diffuse distribution, of opiate receptors in the striatum, and we also studied the different effects of haloperidol and sulpiride on striatal and cortical receptors. We found a significant decrease of the number of (3H)- naloxone binding sites in the striatal patches of treated animals but no effects in the matrix. We also observed, in haloperidol-treated animals, an increase of (3H)-naloxone binding sites in the medial cortex, and in sulpiride-treated animals an increase in the lateral and dorsal cortex. Two main observations arise from our data: (a) a differential effect is produced by neuroleptic treatment on opiate receptors in patches and in matrix; (b) an opposite influence is exerted by sulpiride and haloperidol on opiate receptors in the cortex and in striatum.
Electrochemical AFM Observation of the HOPG Edge Plane in Ethylene Carbonate-Based Electrolytes Containing Film-Forming Additives (2012)

The effects of film-forming additives in electrolyte solutions on the formation of a surface film on edge plane pyrolytic graphite electrodes in lithium ion batteries were investigated by electrochemical atomic force microscopy (AFM). Surface films were formed at around 1.2 V through reductive decomposition of the additives including vinyl ethylene carbonate. The thickness of the surface films, ca. 20 nm, was less than half of that for an electrolyte with no additives, and remained unchanged after the second potential cycle. Most of the surface films could be scraped off by repeated scanning of the surface in contact-mode AFM. However, a very thin surface layer, which was in close contact with the edge plane, remained even after repeated scans by AFM. No precipitate was observed on the scraped part in the subsequent potential cycle, indicating that the remaining thin surface layer could act effectively as a passivating film for the edge plane graphite electrode. Such a passivating surface layer was found to be formed uniformly over the entire surface of the edge plane. These results clearly indicate that surface films with high passivation ability can be effectively formed on the edge plane during the initial cycle by the presence of film-forming additives in electrolytes.
Transient Conduction With Pyrolysis (Approximate Solutions for Charring of Wood Slabs) (1982)

The rate of charring of a heated one-dimensional, wood-like solid slab is predicted by solving the transient conduction equation with a phase-change energy sink term. This solution procedure uses an integral method with spatially-linear-temperature profiles. Two types of front-face boundary conditions are considered—prescribed temperature and prescribed heat flux. The backface is insulated. The prescribed temperature condition leads to the conclusion that for all reasonable exposure temperatures, the slab would only partially char. The maximum char depth is most sensitive to the char conductivity and exposure temperature and less sensitive to the char specific heat and charring endothermicity. Results of the constant flux are in reasonable agreement with the available experimental data both qualitatively and quantitatively.