gebhart/patrepeval huggingface dataset:
A Series of Tertiary Butyl Peresters Showing Concerted Decomposition (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Series of Tertiary Butyl Peresters Showing Concerted DecompositionPaul D. Bartlett and Richard R. HiattCite this: J. Am. Chem. Soc. 1958, 80, 6, 1398–1405Publication Date (Print):March 1, 1958Publication History Published online1 May 2002Published inissue 1 March 1958https://pubs.acs.org/doi/10.1021/ja01539a031https://doi.org/10.1021/ja01539a031research-articleACS PublicationsRequest reuse permissionsArticle Views607Altmetric-Citations172LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Design of Data Warehouse in Network Instruction Quality Analysis System (2009)

Data Warehouse in network instruction system can benefit the analysis of the quality of network instruction;and can scientific help teachers knowing the students' grasp about knowledge scientifically and changing.This class by the analysis of disadvantage in traditional network instruction System.The data warehouse multidimension data model in network instruction system were introduced by the analysis of subject field and granularity,and detailed study in the fact table and demension table.As a foundation.take SQL Server 2000 platforms has given concrete realization.
Korean version of the convalescence and recovery evaluation: translation and linguistic validation (2020)

The Korean version of the CARE questionnaire has been verified and is ready for use. Additional testing steps are required for the psychometric performance of the Korean version of CARE.
Architecture of the Scalable Communications Core's Network on Chip (2007)

The SCC is a flexible and energy-and area-efficient baseband processor for concurrent multiple wireless protocols. Its architecture consists of coarse grained, heterogeneous, programmable accelerators connected via a packet-based, 3-ary 2-cube network on chip. The NOC supports goals of flexibility, scalability, and extensibility, and it meets stringent latency and throughput requirements.
Reactions of unsaturated fatty alcohols. VII. Polymerization of vinyl ethers catalyzed by stannic and ferric chlorides (1960)

Summary Variables affecting the use of stannic chloride as a catalyst for initiating polymerization of conjugated and nonconjugated soybean vinyl ether were studied. Molecular weight of the polymers increased with an increase in catalyst and a decrease in initiation temperature, and it decreased when the amount of moisture in the solvent, the amount of free fatty alcohol in the monomer, or the ratio of solvent to monomer was increased. Aromatic and aliphatic hydrocarbon solvents were superior to halogenated solvents for conducting polymerizations. Similar results were obtained with nonconjugated monomers except that viscosities of the polymers were considerably lower than those of polymers of the same molecular weight obtained from conjugated monomer. To obtain polymers suitable for film‐forming studies (4,000–6,000 molecular weight) polymerization is initiated preferably at 25°C. with 3 ml. of anhydrous toluene used per gram of monomer and 4.8 mmoles of stannic chloride per mole of monomer. Monomer purity should be at least 98%. Ferric chloride hexahydrate initiated polymerization at 25°, but polymerization was incomplete, and the polymers had relatively low molecular weights.
A Multiple-Valued Decision-Diagram-Based Approach to Solve Dynamic Fault Trees (2014)

Dynamic fault trees (DFTs) have been used for many years because they can easily provide a concise representation of the dynamic failure behaviors of general non-repairable fault tolerant systems. However, when repeated failure events appear in real-life DFT models, the traditional modularization-based DFT analysis process can still generate large dynamic subtrees, the modeling of which can lead to a state explosion problem. Examples of these kinds of large dynamic subtrees abound in models of real-world dynamic software and embedded computing systems integrating with various multi-function components. This paper proposes an efficient, multiple-valued decision-diagram (MDD)-based DFT analysis approach for computing the reliability of large dynamic subtrees. Unlike the traditional modularization methods where the whole dynamic subtree must be solved using state-space methods, the proposed approach restricts the state-space method only to components associated with dynamic failure behaviors within the dynamic subtree. By using multiple-valued variables to encode the dynamic gates, a single compact MDD can be generated to model the failure behavior of the overall system. The combination of MDD and state-space methods applied at the component or gate level helps relieve the state explosion problem of the traditional modularization method, for the problems we explore. Applications and advantages of the proposed approach are illustrated through detailed analyses of an example DFT, and through two case studies.
Metastases to hemangioblastomas in von Hippel–Lindau disease (2006)

Hemangioblastomas are an early and preferred site for metastasis in VHL disease. Emerging histopathological techniques may lead to recognition of an increasing number of cases of tumor-to-hemangioblastoma metastasis. Management of cases involving tumor-to-hemangioblastoma metastases in VHL disease should be based on the histological characteristics of the primary tumor, extent of the primary disease, and completeness of the resection.
The Technological Opportunities of Hybrid Electric Vehicles (1996)

&lt;div class="htmlview paragraph"&gt;Hybrid electric vehicles provide the opportunity to greatly reduce fuel consumption, switch to non-petroleum based alternative fuels, provide large reductions in urban air pollution, and provide large reductions in greenhouse gas emissions. This paper presents the technological opportunities of these vehicle types, and the mission and goals of the U S Department of Energy's Hybrid Propulsion Systems Development Program.&lt;/div&gt;
The epidemiology of apnoea of prematurity (2022)

Attempts to elucidate the epidemiology of apnoea of prematurity have been challenging. Studies of AOP are hampered in part by challenges in monitoring the condition, the interplay of multiple comorbidities in preterm neonates and lack of expert consensus definitions. However, since the primary risk factor is preterm birth, efforts to decrease the prevalence of preterm birth would have a positive secondary effect on the prevalence of AOP. Until then, better pharmacotherapeutic options are needed.
Complete Genome Sequence of Salmonella enterica Serovar Pullorum RKS5078 (2012)

Salmonella enterica serovar Pullorum is a chicken-adapted pathogen, causing pullorum disease. Its strict host adaptation has been suspected to result in gene decay. To validate this hypothesis and identify the decayed genes, we sequenced the complete genome of S. Pullorum RKS5078. We found 263 pseudogenes in this strain and conducted functional analyses of the decayed genes.
Ancient Company, Innovating at the Speed of Light (2002)

OVERVIEW:Since 1851, Corning has successfully navigated through periods of tremendous economic and technological change. While change is often difficult to predict, it is important to take advantage of it—responding quickly and, at the same time, strategically positioning the organization for growth. Creating growth requires that heritage, products, markets, and vision come together. At Corning, this is accomplished in a centralized organization headed by a chief technology officer who reports directly to the CEO. They steer an innovation process made up of a balanced portfolio of initiatives and a tolerance for risk that recognizes that one often learns more from failure than from success. The importance of the role of leadership and corporate culture in managing through turbulent times, both good and bad, cannot be underestimated.
Convolutional encoding of 60,64,68,72-bit self-dual codes (2017)

In this paper we obtain the [60,30,12], [64,32,12], [68,34,12], [72,36,12] self-dual codes as tailbitting convolutional codes with the smallest constraint length K=9. In this construction one information bit is modulo two added to the one of the encoder outputs and the first row in the quasi-cyclic generator matrix is replaced by the obtained row. The pure quasi-cyclic construction with K=10 is also available for [68,34,12] and [72,36,12] codes. The new [72,36,12] singly even self-dual code with parameters Beta=483 Gamma=0 was obtained.
The role of the prion protein membrane anchor in prion infection (2009)

Normal cellular and abnormal disease-associated forms of prion protein (PrP) contain a C-terminal glycophosphatidyl-inositol (GPI) membrane anchor. The importance of the GPI membrane anchor in prion diseases is unclear but there are data to suggest that it both is and is not required for abnormal prion protein formation and prion infection. Utilizing an in vitro model of prion infection we have recently demonstrated that, while the GPI anchor is not essential for the formation of abnormal prion protein in a cell, it is necessary for the establishment of persistent prion infection. In combination with previously published data, our results suggest that GPI anchored PrP is important in the amplification and spread of prion infectivity from cell to cell.
Unexpected Isomerism in cis‐2 Bis(pyrrolidino)[60]Fullerene Diastereomers (2013)

Similar yet different: A one-step regio- and diastereoselective synthesis of three new bis(pyrrolidine)[60]fullerenes, one cis-1 and two unprecedented cis-2 diastereoisomers, is reported. The compounds are easily purified using simple chromatographic techniques, and were fully characterized by spectroscopic techniques and X-ray crystallography. A mechanism for the isomeric conversion observed is proposed.
Suppression of penetration of aluminum into 8-hydroxyquinoline aluminum via a thin oxide barrier (1998)

We report a direct observation of Al penetration into an organic film of 8-hydroxyquinoline aluminum (Alq) in a Alq/Al bilayer, a common interface occurring in many organic light-emitting diode structures. The Al penetration has a strong correlation with Alq photoluminescence quenching. We also demonstrate that the penetration and luminescence quenching can be effectively suppressed by ∼20 Å of an intervening layer of Al2O3 at the Alq/Al interface.
Discharge characteristics of canonical sprinkler sprays (2007)

Detailed characterization of spray behavior and its relationship to nozzle geometry, fluid properties, and injection characteristics is needed to advance water-based suppression technology and fire related computational fluid dynamics (CFD) tools. In this study, a series of experiments have been conducted to measure discharge characteristics of sprays produced by basic injector configurations modeled after conventional pendant sprinklers. Liquid jets of various sizes were injected downwards onto flat deflectors, tined deflectors, and boss-modified tined deflectors to establish the three canonical configurations explored in this study. Spray measurements including the initial angle of the sheet at the deflector exit, the sheet breakup radius, the drop size distribution 1 m below the deflector surface, and the volume density distribution were performed for these configurations. These systematic experiments provide discharge characteristics of practical interest while providing valuable data for CFD based atomization model development.
Heterogeneity in oligodendroglia: Is it relevant to mouse models and human disease? (2016)

There are many lines of evidence indicating that oligodendrocyte progenitor cells and oligodendrocyte populations in the central nervous system (CNS) are heterogeneous based on their developmental origins as well as from morphological and molecular criteria. Whether these distinctions reflect functional heterogeneity is less clear and has been the subject of considerable debate. Recent findings, particularly from knockout mouse models, have provided new evidence for regional variations in myelination phenotypes, particularly between brain and spinal cord. These data raise the possibility that oligodendrocytes in these regions have different functional capacities and/or ability to compensate for loss of a specific gene. The goal of this review is to briefly revisit the evidence for oligodendrocyte heterogeneity and then to present data from transgenic and demyelinating mouse models suggesting functional heterogeneity in myelination, demyelination, and remyelination in the CNS and, finally, to discuss the implications of these findings for human diseases. © 2016 Wiley Periodicals, Inc.
Need for a new treatment strategy: leptomeningeal carcinomatosis from gastric cancer (2009)

Leptomeningeal carcinomatosis (LMC) is an extremely rare manifestation of gastric cancer. The treatment options are very limited for LMC; despite standard treatment with intrathecal chemotherapy, the prognosis is grim and the median overall survival is 3-4 months. Here we report on a patient with LMC from metastatic gastric cancer who was treated with a novel approach of high-dose systemic irinotecan, comparable with the dose utilized in treating primary brain tumors such as gliomas. Our patient not only had an excellent tumor response to this novel approach, but also had a prolonged overall survival of 13 months, which is unusual for LMC from gastric cancer.
Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11 (2020)

ABSTRACT Plasmodium sporozoites express circumsporozoite protein (CSP) on their surface, an essential protein that contains central repeating motifs. Antibodies targeting this region can neutralize infection, and the partial efficacy of RTS,S/AS01 – the leading malaria vaccine against P. falciparum (Pf) – has been associated with the humoral response against the repeats. Although structural details of antibody recognition of PfCSP have recently emerged, the molecular basis of antibody-mediated inhibition of other Plasmodium species via CSP binding remains unclear. Here, we analyze the structure and molecular interactions of potent monoclonal antibody (mAb) 3D11 binding to P. berghei CSP (PbCSP) using molecular dynamics simulations, X-ray crystallography, and cryoEM. We reveal that mAb 3D11 can accommodate all subtle variances of the PbCSP repeating motifs, and, upon binding, induces structural ordering of PbCSP through homotypic interactions. Together, our findings uncover common mechanisms of antibody evolution in mammals against the CSP repeats of Plasmodium sporozoites.
TAp73α binds the kinetochore proteins Bub1 and Bub3 resulting in polyploidy (2009)

Aneuploidy is a characteristic of most solid tumors, often associated with negative prognosis. It can arise from two principal mechanisms: from a tetraploid intermediate state, or directly from errors at cell division. The control of cell division, crucial to maintain genomic stability, is still poorly understood in its relationship to aneuploidy. Here we show that the TAp73alpha isoform induces polyploidy when overexpressed. This is possibly due to the interaction of TAp73alpha with kinetochore-related proteins leading to the alteration of mitotic checkpoint abilities. TAp73alpha but not p53 or any of the other p73 isoforms binds Bub1 and Bub3. Since TAp73alpha is frequently overexpressed in cancer, this interaction may contribute to the aneuploidy observed in cancer progression. Our results suggest a novel molecular mechanism leading to aneuploidy involving interference of TAp73alpha with Bub1 and Bub3 resulting in an altered mitotic checkpoint.
Interpretation of In Situ Tests as Affected by Soil Suction / Gerald A. Miller, Rodney W. Collins, Kanthasamy K. Muraleetharan, Amy B. Cerato, Roy Doumet. (2015)

In situ testing of soil with invasive methods such as the Cone Penetration Test (CPT) are increasingly used in geotechnical engineering practice. However, there has been very little work to develop methods for interpreting results of these tests when performed in unsaturated soil. It is important to develop such methods because the in situ test results in unsaturated soil will depend on the moisture conditions at the time of testing and may not reflect the soil behavior corresponding to the moisture conditions during the life of supported structures. Research described in this report involved conducting in situ tests at two test sites, containing lean to fat clayey soils, at various times of the year. The purpose was to investigate the influence of changes in moisture conditions and soil suction on the test response. In situ testing included the Cone Penetration Test (CPT), Standard Penetration Test (SPT) and Pre-bored Pressuremeter Test (PMT). Test sites were characterized by sampling and laboratory testing to determine important soil properties and moisture content profiles. Additionally, test sites were instrumented with weather monitoring equipment and sensors to measure temporal variations in soil moisture with depth. Another goal was to evaluate two commercially available computer programs to evaluate their predictive ability with respect to soil moisture change. The PMT, CPT and SPT parameters determined from standard interpretation of the results were compared to total suction measured at corresponding depths obtained from measurements on samples obtained in the field using a chilled mirror hygrometer. At both sites, the suction had a profound impact on the in situ test parameters, especially at total suction in excess of approximately 150 psi, which generally corresponded to shallow test depths. At both sites, for the shallow depths there was a noticeable trend of increasing magnitude of in situ test parameters with increasing suction, as expected. Plots of normalized in situ test parameters against suction show expected, albeit weak, correlations for the two test sites. These correlations give a sense of the variation of in situ parameters that might be expected for similar soils under changing suction conditions. It was demonstrated how correlations for PMT, CPT and SPT parameters with suction can be used to roughly predict possible changes in these parameters as a result of suction changes. Unsaturated seepage modeling was found to provide reasonable comparisons to measured soil moisture profiles; however, significant effort was required to define the various input parameters through calibration procedures.
The Model-Based Performance Index for Stabilization of Linear and Nonlinear Systems (2019)

Model-based cost functions are developed to build optimal stabilizing controllers for linear and nonlinear systems. The prescribed model-based cost functions can be selected to impose a specific desired performance of the closed-loop system. The proposed approach differs from the classical optimal control formulation in the sense that the objective function and the system dynamics are fused in one criterion. As a result, the optimal control law is finally built as the solution to an unconstrained optimization problem. For systems that are not affine in the control input, dynamic feedbacks are proposed as the gradient flow of model-based performance indices.
Femtochemistry of Norrish Type-I Reactions: I. Experimental and Theoretical Studies of Acetone and Related Ketones on the S1 Surface (2001)

The dissociation dynamics of two acetone isotopomers ([D0 ]- and [D6 ]acetone) after 93 kcal mol(-1) (307 nm) excitation to the S1 (n,π*) state have been investigated using femtosecond pump-probe mass spectrometry. We found that the nuclear motions of the molecule on the S1 surface involve two time scales. The initial femtosecond motion corresponds to the dephasing of the wave packet out of the Franck-Condon region on the S1 surface. For longer times, the direct observation of the build-up of the acetyl radical confirms that the S1 α-cleavage dynamics of acetone is on the nanosecond time scale. Density functional theory and ab initio calculations have been carried out to characterize the potential energy surfaces for the S0 , S1 , and T1 states of acetone and six other related aliphatic ketones. For acetone, the S1 energy barrier along the single α-positioned carbon-carbon (α-CC) bond-dissociation coordinate (to reach the S0 /S1 conical intersection) was calculated to be 18 kcal mol(-1) (∼110 kcal mol(-1) above the S0 minimum) for the first step of the nonconcerted α-CC bond cleavage; the concerted path is energetically unfavorable, consistent with experiments. The S1 barrier heights for other aliphatic ketones were found to be substantially lower than that of acetone by methyl substitutions at the α-position. The α-CC bond dissociation energy barrier of acetone on the T1 surface was calculated to be only 5 kcal mol(-1) (∼90 kcal mol(-1) above the S0 minimum), which is substantially lower than the barrier on the S1 surface. Based on the calculations, the α-cleavage reaction mechanism of acetone occurring on the S0 , S1 , and T1 surfaces can be better understood via a simple physical picture within the framework of valence-bond theory. The theoretical calculations support the conclusion that the observed nanosecond-scale S1 dynamics of acetone below the barrier is governed by a rate-limiting S1 →T1 intersystem crossing process followed by α-cleavage on the T1 surface. However, at high energies, the α-cleavage can proceed by barrier crossing on the S1 surface, a situation which is demonstrated for cyclobutanone in the accompanying paper.
Predicting quality of life outcomes after subthalamic nucleus deep brain stimulation (2014)

The findings provide greater insight into the nonmotor features that contribute to the success of subthalamic nucleus DBS procedures from the patient's perspective and raise questions about the treatment focus and emphasis on symptom profiles in DBS candidacy evaluations.
(Biphenyl-2,2′-diyl)[1,3-bis(diphenylphosphanyl)propane-κ2P,P′]platinum(II) (2016)

The C 2 P 2 donor set in the title compound, [Pt(C 12 H 8 )(C 27 H 26 P 2 )], defines a distorted planar coordination environment about the Pt II atom with small deviations from planarity. The bidentate nature of the biphenyl dianionic ligand results in a C—Pt—C bond angle of 79.94 (16)° and a P—Pt—P bond angle of 93.40 (4)°. The average Pt—C bond length is 2.083 (3) Å [range 2.081 (4)–2.085 (4) Å]; the average Pt—P bond length is 2.308 (8) Å [range 2.3030 (11)–2.3136 (11) Å].
Ultrasonic Welding of Helicopter Secondary Structure Components. (1977)

Abstract : Ultraonic welding was evaluated as a means for assembling helicopter secondary structures. Such welds in several combinations of 2024- and 6061 aluminum alloys demonstrated tensile-shear strengths of more than 2.5 times the strength of resistance spot welds. Inner and outer skins of helicopter doors (0.020-inch 2024-T3 Alclad to 0.025-inch 6061-T6 Alclad aluminum alloys) assembled by this process successfully withstood air loads of five to ten times the design loading for the door. A process specification for use of ultrasonic welding in nostructural and secondary structure components for AAH aircraft was prepared for use at Hughes Helicopters. It was recommended that the process be validated for other materials and material combinations and that ultrasonic welding and ultrasonic weld bonding be evaluated for aircraft primary structures.