gebhart/patrepeval huggingface dataset:
Native store extension for SAP HANA (2019)

We present an overview of SAP HANA's Native Store Extension (NSE). This extension substantially increases database capacity, allowing to scale far beyond available system memory. NSE is based on a hybrid in-memory and paged column store architecture composed from data access primitives. These primitives enable the processing of hybrid columns using the same algorithms optimized for traditional HANA's in-memory columns. Using only three key primitives, we fabricated byte-compatible counterparts for complex memory resident data structures (e.g. dictionary and hash-index), compressed schemes (e.g. sparse and run-length encoding), and exotic data types (e.g. geo-spatial). We developed a new buffer cache which optimizes the management of paged resources by smart strategies sensitive to page type and access patterns. The buffer cache integrates with HANA's new execution engine that issues pipelined prefetch requests to improve disk access patterns. A novel load unit configuration, along with a unified persistence format, allows the hybrid column store to dynamically switch between in-memory and paged data access to balance performance and storage economy according to application demands while reducing Total Cost of Ownership (TCO). A new partitioning scheme supports load unit specification at table, partition, and column level. Finally, a new advisor recommends optimal load unit configurations. Our experiments illustrate the performance and memory footprint improvements on typical customer scenarios.
Two cytodifferentiation agent-induced pathways, differentiation and apoptosis, are distinguished by the expression of human papillomavirus 16 E7 in human bladder carcinoma cells. (1997)

Many transformed cells have been found to lose the capacity to proliferate and undergo differentiation following exposure to hybrid polar agents. This study investigates the mechanism by which hexamethylene bisacetamide (HMBA) suppresses the proliferation of the human bladder carcinoma line, T24. We found that following a 24-h exposure to HMBA, T24 proliferation was inhibited, and cells arrested in G1 phase and underwent morphological maturation. HMBA-induced cessation of proliferation was mediated, in part, by effects on cell cycle regulatory proteins. In T24 cells cultured without HMBA, E2F complexes predominantly with p107. In culture with inducer, p107 protein decreased, pRB and p130 were converted to underphosphorylated forms, and E2F was shifted into complexes with pRB and p130. To determine whether the formation of pRB:E2F and p130:E2F complexes was required for the HMBA-induced G1 arrest, the ability of the pocket proteins to bind E2F was blocked by enforced expression of human papillomavirus 16 E7. Following culture with HMBA, the T24 clones expressing E7 died, whereas vector-alone T24 clones arrested in G1 phase. T24/E7-1 cells did not form pRB:E2F or p130:E2F complexes upon culture with HMBA; rather, E2F was present in its free form. T24/E7-1 cells cultured with HMBA initially accumulate in G1. By day 2, they have entered into S phase, and by day 3, over 80% of the cells became apoptotic. Taken together, these studies enlarge the repertoire of demonstrated developmental pathways that may be triggered in transformed cells, depending upon their molecular status, and may provide potential therapeutic opportunities for cancer.
Novel monoclonal antibodies against microcystin and their protective activity for hepatotoxicity (1995)

Six monoclonal antibodies (MAbs) to microcystin-LR (MCLR), a cyclic heptapeptide hepatotoxin isolated from the cyanobacterium Microcystis aeruginosa, were produced. They showed the protective effects on hepatotoxicity of MCLR in vitro and in vivo, and on the inhibition of protein phosphatase by MCLR. Competitive enzyme-linked immunosorbent assays with various microcystins revealed that the six MAbs recognized a part of the molecule, in particular, a tertial structure around Adda, 3-amino-9-methoxy-2,6,8,-trimethyl-10-phenyldeca-4,6-dienoic acid. The specificity of these MAbs varied slightly. In primary rat hepatocyte cultures, all MAbs showed protective effects against the MCLR-induced cell damages, assessed by morphological changes, lactate dehydrogenase release into the medium, and a calorimetric assay to measure the cell viability using a tetrazolium dye. The M8H5 MAb showing the highest affinity for MCLR blocked the lethal effects and hepatocellular damage to mice. In addition, M8H5 MAb recovered protein phosphatase 2A inhibition by MCLR in a dose-dependent manner, while phosphatase inhibition by okadaic acid was not affected. Thus, the MAbs specifically reacted with the microcystins and prevented their biological activities. This is the first report on the protective effects of specific monoclonal antibodies on MCLR-induced toxicity.
[Electrical stimulation of the visual system. From empirical approach to visual prostheses]. (2001)

The investigation of the influence of electrical stimulation on the visual system can be sub-divided into empirical, diagnostic and therapeutic phases of development. The first electrical stimulations of the visual system in animals dating back to the eighteenth century represent empirical approaches well before knowledge on the principles of bioelectrical nerve activity was available. Despite this lack of understanding, attempts were made at that time to treat blind people by electrical stimulation. More than 100 years later, with the advancement of technology and knowledge on nerve function, attempts were made to establish various methods of electrical stimulation for the diagnosis of different diseases of the visual system. For more than 30 years attempts to develop electrical devices have been made to by-pass defects of the visual system and to restore basic orientation. Presently nine different groups world-wide are focusing on retinal, optic or cortical implants. A short review on the historical use of electrical stimulation and new therapeutical attempts are given in this paper.
A rigorous three plane mode-matching technique for characterizing waveguide T-junctions, and its application in multiplexer design (1991)

A rigorous method for modeling rectangular waveguide T-junctions is presented. The method characterizes the waveguide discontinuity three times the side-arm of the T-junction is terminated in a short circuit with three different lengths, and hence is called the three plane mode-matching technique (TPMMT). Computed and measured data on both E-plane and H-plane T-junctions are compared, showing excellent agreement for the magnitudes and phases of the scattering matrix elements. Element values of equivalent circuit models are computed and approximated by simple polynomials or rational functions, given excellent accuracy. By using the S-parameters obtained from the TPMMT method, a network model of a waveguide manifold multiplexer is formulated. All parameters of the multiplexer, including the manifold dimensions and the filters, are optimized using this network model in terms of the multiplexer specification. The experimental results match the computed optimum results without further adjustment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Spectral stabilization of linear transport equations with boundary and in-domain couplings (2022)

In this work, the problem of stabilization of general systems of linear transport equations with in-domain and boundary couplings is investigated. It is proved that the unstable part of the spectrum is of finite cardinal. Then, using the pole placement theorem, a linear full state feedback controller is synthesized to stabilize the unstable finite-dimensional part of the system. Finally, by a careful study of semigroups, we prove the exponential stability of the closed-loop system. As a by product, the linear control constructed before is saturated and a fine estimate of the basin of attraction is given.
Delay Modeling and Statistical Design of Pipelined Circuit Under Process Variation (2006)

Under inter-die and intra-die parameter variations, the delay of a pipelined circuit follows a statistical distribution. This paper presents analytical models to estimate yield for a pipelined design based on delay distributions of individual pipe stages. Using the proposed models, it is shown that a change in logic depth and an imbalance between stage yields can improve the design yield and the area of a pipeline a circuit. A novel statistical methodology is developed to enhance yield of a pipelined circuit under an area constraint. Based on the concept of area borrowing, the results show that incorporating a proper imbalance among stage areas in a four-stage pipeline improves design yield up to 15.4% for the same area (and reduces area up to 8.4% under a yield constraint) compared with a balanced design
Ultrasonically initiated emulsion polymerization of n‐butyl acrylate (2001)

Abstract Ultrasonically initiated emulsion polymerization of n ‐butyl acrylate (BA) without added initiator has been studied. The experimental results show that high conversion of BA can be reached in a short time by employing an ultrasonic irradiation technique with a high purge rate of N 2 . The viscosity average molecular weight of poly( n ‐butyl acrylate) (PBA) obtained reaches 5.24 × 10 6 g mol −1 . The ultrasonically initiated emulsion polymerization is dynamic and complicated, with polymerization of monomer and degradation of polymer occurring simultaneously. An increase in ultrasound intensity leads to an increase in polymerization rate in the range of cavitation threshold and cavitation peak values. Lower monomer concentration favours enhancement of the polymerization rate. 1 H NMR, 13 C NMR and FTIR spectroscopies reveal that there are some branches and slight crosslinking, and also carboxyl groups in PBA. Ultrasonically initiated emulsion polymerization offers a new route for the preparation of nanosized latex particles; the particle size of PBA prepared is around 50–200 nm as measured by transmission electron microscopy. © 2001 Society of Chemical Industry
A 12‐month study of the placebo effect in transurethral microwave thermotherapy (1996)

The benefit from TUMT cannot be due to a placebo effect alone.
A system for change detection and human recognition in voxel space using the Microsoft Kinect sensor (2011)

Previously, we put forth a new computer vision system for indoor well-being monitoring of elderly populations based on the use of multiple stereo camera pairs. That approach involves combining the strengths of image space with three dimensional volume element (voxel) space techniques. However, that system is fundamentally limited because it is based on color imagery from visible light cameras. In this article, we extend our prior research and consider a new, inexpensive infrared depth camera device, the Microsoft Kinect. Advantages, such as the ability to operate 24-7 in low-to-no light conditions, and shortcomings are detailed. In addition, we discuss necessary algorithmic extensions to our mixed image and voxel space framework for the Kinect sensor. Experiments are performed in a laboratory designed to resemble an elders living quarter. Vision findings are evaluated using our prior high-level linguistic summarization of human activity work. Preliminary results indicate that the Kinect sensor does indeed work in a wider range of operating conditions and it can produce activity descriptions that match that of a human.
Cross-Clade Reactivity of HIV-1-Specific T-cell Responses in HIV-1-Infected Individuals From Botswana and Cameroon (2006)

An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B Gag and/or clade B Nef in Botswana (95%) and Cameroon (98%) were similar when compared with those in countries previously studied, including Brazil (92%), Thailand (96%), South Africa (96%), Malawi (100%), and the United States (100%). Substantial cross-clade cell-mediated immune responses in Botswana and Cameroon confirm previous findings in a larger, more genetically diverse collection of HIV-1 samples.
Neuropsychological Deficits in Mice Depleted of the Schizophrenia Susceptibility Gene CSMD1 (2013)

Recent meta-analyses of schizophrenia genome-wide association studies (GWASs) have identified the CUB and SUSHI multiple domains 1 (CSMD1) gene as a statistically strong risk factor. CSMD1 is a complement control-related protein suggested to inhibit the classical complement pathway, being expressed in developing neurons. However, expression of CSMD1 is largely uncharacterized and relevance for behavioral phenotypes is not previously demonstrated. Here, we assess neuropsychological behaviors of a Csmd1 knockout (KO) mouse in a selection of standard behavioral tests. Deregulation of neuropsychological responses were observed in both the open field and the elevated plus maze tests, in which KO mice spent 55% and 33% less time than WT littermate mice in open areas, respectively. Altered behaviors were also observed in tail suspension and to higher acoustic stimuli, for which Csmd1 KO mice showed helplessness and moderate increase in startle amplitude, respectively. Furthermore, Csmd1 KO mice also displayed increased weight-gain and glucose tolerance, similar to a major phenotype of the metabolic syndrome that also has been associated to the human CSMD1 locus. Consistent with a role in the control of behaviors, Csmd1 was found highly expressed in the central nervous system (CNS), and with some expression in visceral fat and ovary, under tissue-specific control by a novel promoter-associated lncRNA. In summary, disruption of Csmd1 induces behaviors reminiscent of blunted emotional responses, anxiety and depression. These observations suggest an influence of the CSMD1 schizophrenia susceptibility gene on psychopathology and endophenotypes of the negative symptom spectra.
Generation of Scenes in Intersections for the Validation of Highly Automated Driving Functions. (2019)

The simulation of traffic scenes in the environment of an automated vehicle promises to make significant contribution to the validation of automated driving. The construction of models which describe traffic scenes in a generic manner is complicated, since the parameter space of the scenes is infinite. This paper introduces a statistical approach to generate traffic scenes in intersections. A generic model which allows us to represent the scenes is proposed. The concept of Bayesian networks is used to fit the model onto a publicly accessible dataset and to infer traffic scenes from the model. A quantitative evaluation of the results is achieved by the calculation of the total variation distance (TVD) between the distributions of several physical properties.
Glomerular hyperfiltration during sympathetic nervous system activation in early essential hypertension. (1997)

Glomerular hyperfiltration may be important for the development of essential hypertension. Both the renin-angiotensin system and the sympathetic nervous system influence renal hemodynamic regulation. To test the hypothesis that glomerular hyperfiltration can be unmasked by sympathetic nervous system activation, renal hemodynamics and humoral components of the renin-angiotensin system were examined at rest and during mental stress in 45 young normotensive healthy subjects and 37 young people with mild essential hypertension. GFR and renal plasma flow (RPF) were determined with inulin and para-aminohippuric acid clearance at rest and during stress. At rest, RPF, GFR, filtration fraction, plasma renin activity, angiotensin (Ang) II concentrations, and serum aldosterone values were similar in normotensive and hypertensive subjects. After stress, blood pressure increased (P < 0.01), but this was nearly identical in normotensive and hypertensive subjects (7.05 +/- 6.9 versus 7.03 +/- 4.6 mmHg, NS). The decrease in RPF (-27 +/- 54 versus -22 +/- 25 ml/min per 1.73 m2, NS) was also similar in the two groups. In contrast, the increase in GFR (+ 10.5 +/- 7.2 versus 6.08 +/- 5.7 ml/min per 1.73 m2, P < 0.001) and filtration fraction (+2.48 +/- 1.38 versus 1.82 +/- 1.49%, P < 0.05) was more marked in hypertensive than in normotensive subjects. The concomitant increase in Ang II concentrations was greater in hypertensive than in normotensive subjects (+4.6 +/- 1.0 versus -1.0 +/- 0.45 pg/ml, P < 0.001). The increase in GFR during mental stress was correlated with the increment in Ang II concentrations (r = 0.39, P < 0.001). Compared with the placebo control phase, blockade of the renin-angiotensin system with an angiotensin-converting enzyme inhibitor attenuated the increase in GFR during stress in hypertensive (8.04 +/- 5.01 versus 10.1 +/- 5.7 ml/min per 1.73 m2, P < 0.05), but not in normotensive, subjects. Even in early essential hypertension, glomerular hyperfiltration is evident during sympathetic nervous system activation, which is mediated by postglomerular vasoconstriction. This early stress-induced glomerular hyperfiltration may contribute to, or trigger, the development of essential hypertension.
Transient receptor potential ankyrin 1 (TRPA1) antagonists: a patent review (2015–2019) (2020)

During 2015-2019, significant progress was made toward the discovery of new TRPA1 antagonists. A total of 14 organizations published 28 patent applications disclosing several distinct classes of chemical matter and potential uses. During this period, three new molecules entered the clinic (ODM-108, HX-100, and GDC-0334) bringing the total number of TRPA1 antagonists to reach clinical trials to five (including earlier molecules CB-625 and GRC 17536); however, to our knowledge, development of all five molecules have been discontinued. Further clinical trials of recent TRPA1 antagonists with good pharmacokinetics would be needed to help understand TRPA1 involvement in human diseases and its potential as a therapeutic target.
How to Decrease the Cost of Healthcare (2020)

Healthcare is among the most important issues for Americans since the U.S. healthcase system is the most expensive in the world. Public spending, including governmental spending, social health insurance, and compulsory private insurance constitutes the largest source of healthcare spending. By analyzing the reasons of high healthcare costs the paper contributes to the ongoing policy debates how to improve the current healthcare system
Increased Expression of Regulator of G Protein Signaling-2 (RGS-2) in Bartter’s/Gitelman’s Syndrome. A Role in the Control of Vascular Tone and Implication for Hypertension (2004)

Regulator of G protein signaling-2 (RGS-2) plays a key role in the G protein-coupled receptor (GPCR) angiotensin II (Ang II) signaling. NO and cGMP exert a vasodilating action also through activation and binding to RGS-2 of cGMP dependent protein kinase 1-alpha, which phosphorylates RGS-2 and dephosphorylates myosin light chain. In Bartter's/Gitelman's patients (BS/GS) Ang II related signaling and vasomotor tone are blunted. Experiments were planned to explore whether RGS-2 may play a role in BS/GS vascular hyporeactivity. NO metabolites and cGMP urinary excretion were also measured. Mononuclear cells (PBM) from six BS/GS patients and six healthy controls were used. PBM RGS-2 mRNA and RGS-2 protein were increased in BS/GS: 0.47 +/- 0.06 d.u. vs 0.32 +/- 0.04, (p < 0.006) (RGS-2 mRNA), and 0.692 +/- 0.02 vs 0.363 +/- 0.06 (p < 0.0001) (RGS2 protein). Incubation of PBM with Ang II increased RGS-2 protein in controls (from 0.363 +/- 0.06 d.u. to 0.602 +/- 0.05; p < 0.0001) but not in BS/GS (from 0.692 +/- 0.02 to 0.711 +/- 0.02). NO(2)(-)/NO(3)(-) and cGMP urinary excretion were increased in BS/GS (0.46 +/- 0.13 vs 0.26 +/- 0.05 micromol/micromol of urinary creatinine, p < 0.005, and 0.060 +/- 0.030 vs 0.020 +/- 0.01 p < 0.009, respectively). These results demonstrate that RGS-2 is increased and maximally stimulated in BS/GS and human RGS-2 system reacts as predicted by knockout mice experiments. This is the first report of RGS-2 level in a human clinical condition characterized by altered vascular tone, underlines the importance of RGS-2 as a key regulator element for Ang II signaling and provides insight into the links between BS/GS genetic abnormalities and abnormal vascular tone regulation.
CL‐20 performance exceeds that of HMX and its sensitivity is moderate (1997)

Abstract The explosive performance of ϵ‐CL‐20 was found to be approximately 14% greater than HMX as determined by cylinder expansion and tantalum plate acceleration experiments. This makes it the most powerful explosive ever tested at small volume expansions of the detonation products. In general CL‐20 is more sensitive than HMX. However, the sensitivity of CL‐20 to one‐dimensional shock loading was found to be similar to HMX.
Supplementary Tables from Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer (2023)

&lt;p&gt;Supplementary Table 1: Results of segregation analyses incorporating mismatch repair gene and MUTYH mutation carrier status. Supplementary Table 2. Estimated population carrier frequency of a mismatch repair gene or MUTYH mutation from previous studies and current study.&lt;/p&gt;
Interspecies Implantation and Mitochondria Fate of Panda-Rabbit Cloned Embryos1 (2002)

Somatic cell nuclei of giant pandas can dedifferentiate in enucleated rabbit ooplasm, and the reconstructed eggs can develop to blastocysts. In order to observe whether these interspecies cloned embryos can implant in the uterus of an animal other than the panda, we transferred approximately 2300 panda-rabbit cloned embryos into 100 synchronized rabbit recipients, and none became pregnant. In another approach, we cotransferred both panda-rabbit and cat-rabbit interspecies cloned embryos into the oviducts of 21 cat recipients. Fourteen recipients exhibited estrus within 35 days; five recipients exhibited estrus 43-48 days after embryo transfer; and the other two recipients died of pneumonia, one of which was found to be pregnant with six early fetuses when an autopsy was performed. Microsatellite DNA analysis of these early fetuses confirmed that two were from giant panda-rabbit cloned embryos. The results demonstrated that panda-rabbit cloned embryos can implant in the uterus of a third species, the domestic cat. By using mitochondrial-specific probes of panda and rabbit, we found that mitochondria from both panda somatic cells and rabbit ooplasm coexisted in early blastocysts, but mitochondria from rabbit ooplasm decreased, and those from panda donor cells dominated in early fetuses after implantation. Our results reveal that mitochondria from donor cells may substitute those from recipient oocytes in postimplanted, interspecies cloned embryos.