gebhart/patrepeval huggingface dataset:
Black bear (Ursus americanus) functional resource selection relative to intraspecific competition and human risk (2017)

The spatial scales at which animals make behavioral trade-offs is assumed to relate to the scales at which factors most limiting resources and increasing mortality risk occur. We used global positioning system collar locations of 29 reproductive-age female black bears (Ursus americanus Pallas, 1780) in three states to assess resource selection relative to bear population-specific density, an index of vegetation productivity, riparian corridors, or two road classes of and within home ranges during spring–summer of 2009–2013. Female resource selection was best explained by functional responses to vegetation productivity across nearly all populations and spatial scales, which appeared to be influenced by variation in bear density (i.e., intraspecific competition). Behavioral trade-offs were greatest at the landscape scale, but except for vegetation productivity, were consistent for populations across spatial scales. Females across populations selected locations nearer to tertiary roads, but females in Michigan and Mississippi selected main roads and avoided riparian corridors, whereas females in Missouri did the opposite, suggesting population-level trade-offs between resource (e.g., food) acquisition and mortality risks (e.g., vehicle collisions). Our study emphasizes that female bear population-level resource selection can be influenced by multiple spatially dependent factors, and that scale-dependent functional behavior should be identified for management of bears across their range.
Simultaneous measurement of the phase and group indices and the thickness of transparent plates by low-coherence interferometry (1998)

We propose and demonstrate a novel technique for simultaneous measurement of the phase index, n(p) , the group index, n(g) , and the thickness, t , of transparent plates by use of a low-coherence interferometer. The output light from a superluminescent diode is focused upon the front plane of a transparent plate that is used as the sample. The sample stage is subsequently moved until the light is focused upon the rear plane of the plate. Measurement of the stage movement distance and the corresponding optical path difference allows us to determine both n(p) and n(g) . By placing the sample between two glass plates, we measured n(p) , n(g) , and t simultaneously, with an error of 0.3% or less, for nearly 1-mm-thick transparent plates, including glass and electro-optic crystals.
In vivo human coronary magnetic resonance angiography at 7 Tesla (2009)

Introduction. Cardiac MRI at high fields faces many challenges including the lack of commercially available body RF coils, increased sample-induced B1 inhomogeneity, increased magnetic susceptibility effects which make imaging with balanced sequences difficult, and SAR limitations. However, if these can be at least partially overcome, then the higher signal-to-noise is advantageous both for imaging and localized spectroscopy. Here we investigate the feasibility of acquiring coronary magnetic resonance angiography (CMRA) scans, a promising technique for the non-invasive visualization of the coronary anatomy (1), in volunteers at 7 tesla (T) on a time-scale acceptable for clinical studies.
Design methodology for efficient frequency conversion in Bragg reflection lasers (2012)

Bragg reflection waveguides are shown to be structures that can enable the integration of a laser and optically nonlinear medium within the same cavity for efficient frequency conversion. An effective and simple method of designing phase-matched laser structures utilizing transfer matrix analysis is described. The structures are first optimized in terms of laser performance and then for enhancement of χ(2) nonlinearity. The method for optimization shows that designing for either optimum laser performance or optimum nonlinear performance can conflict. An efficiency term encompassing the requirements of both the laser and nonlinear element is derived. This serves as a figure of merit that includes parameters relevant to both the laser and the nonlinear device. It is then utilized to optimize the structure for efficient parametric conversion. This figure of merit is extended to examine parametric oscillation in the laser cavity for both singly resonant and doubly resonant configurations. It is found that threshold values of 4 W in a practical device can be obtained. Such power levels are easily obtained by mode locking the pump laser. With reduced propagation loss through etch and design improvement, sub-Watt thresholds can be realized.
JAAM Nationwide Survey on the response to the first wave of COVID‐19 in Japan. Part I: How to set up a treatment system in each hospital (2020)

Acute care physicians and physicians in other departments experienced high levels of stress as they fought to arrange COVID-19 treatment teams and inpatient COVID-19 wards for infected patients. Medical materials and equipment may be sufficient for a second or third wave; however, active support is needed for the physical and mental care of medical staff. Mental health problems may be missed in facilities without mental check and consultation system.
Crystal Forms of Piroxicam Pivalate: Preparation and Characterization of Two Polymorphs (1998)

This study investigates the polymorphism of piroxicam ester with pivalic acid. Two crystal modifications were prepared by recrystallization from toluene (form 1) and ethyl acetate (form 2). Data regarding preparation conditions, solid state properties, and physicochemical characterization of two polymorphs by means of FT/IR spectroscopy, X-ray diffractometry on powder, and thermal analysis are reported. Heat of fusion rule and thermodynamic formulas consistently indicate an enantiotropic stability relationship of forms 1 and 2 with a calculated transition point (32 degrees C) near the ambient temperature. The phase diagrams of each polymorph with piroxicam were also investigated in order to gain information about the thermal behavior of their solid mixtures. Liquidus curves calculated by the Schröder-Van Laar equation from fusion enthalpies and temperatures were found to agree satisfactorily with experimental results obtained by first heating runs with differential scanning calorimetry.
Relationship between microbial flora and skin surface conditions on healthy female subjects. (1986)

The microbial flora of the facial skin was examined through the year for 41 healthy female subject. In order to study the relationship between microbial flora and skin surface conditions, physiological parameters (skin surface lipid, skin surface morphology and Transepidermal Water Loss) were also determined. The facial skin types were classified by skin surface lipid and skin surface morphology.The predominant microorganisms on the skin were Propionibacterium acnes as anaerobic bacteria and Staphylococcus S2, aerobic diphtheroids, micrococci as aerobic, and incidence of micrococci was increased in winter. Aerobic bacteria were clossly related to TWL and skin surface morphology and it was shown that micrococci were detected more frequently on the dry and flaky skin. In the relationship between microbial flora and skin type, it was shown that P. acnes was predominantly detected on every type skin. On the other hand Staphylococcus S2 was predominantly isolated on the “normal skin”. micrococci were found on the “dry-type, oily skin” and both Staphylococcus S2 and aerobic diphtheroids were on the “oily skin”, respectively. Furthermore, it was revealed that staphylococci and the supernatants of the culture fluid inhibit the growth of micrococci.From these results, it was suggested that dry and flaky skin or “dry-type, oily skin” would be improved by inhibition of growth of micrococci with staphylococci.
Relative Habitat Value Of Alternative Substrates Used In Oyster Reef Restoration (2013)

Oyster reef habitats have declined from historic levels due to a variety of reasons, including overharvest, disease, and degraded water quality. The harvesting of oysters has led to a loss of reef habitat for both oysters and reef-associated fauna. When oysters spawn, the larval oysters, or spat, depend on hard substrate for settlement and growth. Oyster shell is the preferred substrate for use in restoration because it most closely matches natural reef habitat, but it is often expensive and in limited supply. This study incorporated field and laboratory experiments to assess the relative habitat value of alternative substrates (crushed concrete, porcelain, crushed limestone, and river rock, as well as oyster shell) for larval oyster recruitment as well as reef resident fishes and macro-invertebrates. Replicate trays of each substrate type were deployed in St. Charles Bay, TX for four months during spring and summer 2012 and assessed for oyster recruitment and faunal diversity and density. Concrete, river rock, limestone and porcelain had similar spat recruitment densities compared to oyster shell (1300-2300 spat). Spat shell heights were also larger on these substrates (13-16 mm), while spat on porcelain substrates were slightly smaller (10-13 mm). All substrates except bare sediment had similar fauna species densities (200-500 individuals m-2). Limestone had lower fauna diversity (H’; 0-1) than concrete and shell (1-2). Laboratory experiments compared the effectiveness of these substrates in providing prey refuge from pinfish and blue crab predators. All substrates performed similarly resulting in very low (&lt;20 %) prey mortality rates for either predator. Results may enable future restoration plans to be implemented at a lower cost while providing similar habitat functions.
mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells (2019)

In myeloid dendritic cells (DC), deletion of the mechanistic target of rapamycin complex 2 (TORC2) results in an augmented pro-inflammatory phenotype and T cell stimulatory activity; however, the underlying mechanism has not been resolved. Here, we demonstrate that mouse bone marrow-derived TORC2-deficient myeloid DC (TORC2<sup>-/-</sup> DC) utilize an altered metabolic program, characterized by enhanced baseline glycolytic function compared to wild-type WT control (Ctrl) DC, increased dependence on glycolytic ATP production, elevated lipid content and higher viability following stimulation with LPS. In addition, TORC2<sup>-/-</sup> DC display an increased spare respiratory capacity (SRC) compared to WT Ctrl DC; this metabolic phenotype corresponds with increased mitochondrial mass and mean mitochondrial DNA copy number, and failure of TORC2<sup>-/-</sup> DC mitochondria to depolarize following LPS stimulation. Our data suggest that the enhanced metabolic activity of TORC2<sup>-/-</sup> DC may be due to compensatory TORC1 pathway activity, namely increased expression of multiple genes upstream of Akt/TORC1 activity, including the integrin alpha IIb, protein tyrosine kinase 2/focal adhesion kinase, IL-7R and Janus kinase 1(JAK1), and the activation of downstream targets of TORC1, including p70S6K, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and CD36 (fatty acid translocase). These enhanced TORC1 pathway activities may culminate in increased expression of the nuclear receptor peroxisome proliferator-activated receptor γ (Pparγ) that regulates fatty acid storage, and the transcription factor sterol regulatory element-binding transcription factor 1 (Srebf1). Taken together, our data suggest that TORC2 may function to restrain TORC1-driven metabolic activity and mitochondrial regulation in myeloid DC.
Subcutaneous Incisionless (Subcision) Surgery for the Correction of Depressed Scars and Wrinkles (1995)

This technique is useful in treating a variety of cutaneous depressions, including scars and wrinkles.
On the application of a non‐CPMG single‐shot fast spin‐echo sequence to diffusion tensor MRI of the human brain (2002)

The strong sensitivity of Carr-Purcell-Meiboom-Gill (CPMG) fast spin-echo (FSE) sequences, such as rapid acquisition with relaxation enhancement (RARE), to the phase of the prepared transverse magnetization means that artifact-free single-shot diffusion-weighted images can currently only be obtained with a 30-50% reduction in the signal-to-noise ratio (SNR). However, this phase sensitivity and signal loss can be addressed in FSE sequences that use quadratic phase modulation of the radiofrequency (RF) refocusing pulses to generate a sustained train of stable echoes. Here the first application of such a non-CPMG single-shot FSE (ssFSE) sequence to diffusion tensor MR imaging (DT-MRI) of the human brain is described. This approach provides high SNR diffusion-weighted images that have little or no susceptibility to poor B(0) magnetic field homogeneity and the strong eddy currents typically present in DT-MRI experiments.
PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R (2018)

The prevention and management of myocardial ischemia/reperfusion (MI/R) injury is an essential part of coronary heart disease surgery and is becoming a major clinical problem in the treatment of ischemic heart disease. Previous studies by our group have demonstrated that pigment epithelium‑derived factor (PEDF) improves cardiac function in rats with acute myocardial infarction and reduces hypoxia‑induced cell injury. However, the protective function and mechanisms underlying the effect of PEDF in MI/R injury remain to be fully understood. In the present study, the positive effect of PEDF in MI/R injury was confirmed by construction of the adult Sprague‑Dawley rat MI/R model. PEDF reduced myocardial infarct size and downregulated cardiomyocyte apoptosis in the I/R myocardium in this model. In addition, PEDF improved cardiac function and increased cardiac functional reserve in rats subjected to MI/R Injury. To further study the protective effect of PEDF and the underlying mechanisms in MI/R injury, a H9c2 cardiomyocyte hypoxia/reoxygenation (H/R) model was constructed. PEDF was confirmed to decrease H/R‑induced apoptosis in H9c2 cells, and this anti‑apoptotic function was abolished by pigment epithelium‑derived factor‑receptor (PEDF R) small interfering (si)RNA. Furthermore, administration of PEDF decreased the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) in H/R H9c2 cells. Compared with the H/R group, PEDF decreased mitochondrial ROS, increased the mitochondrial DNA copy number, reduced xanthine oxidase and NADPH oxidase activity, as well as RAC family small GTPase 1 protein expression. However, these effects of PEDF were markedly attenuated by PEDF‑R siRNA. To the best of our knowledge, the present study is the first to identify the protective effect of PEDF in MI/R injury, and confirm that the antioxidative effect PEDF occurred via inhibition of ROS generation via PEDF‑R under MI/R conditions.
Preparation of a SERS substrate and its sample-loading method for point-of-use application (2009)

A simple approach was demonstrated to prepare a silver (Ag) nanoparticle (NP) assembly as a SERS substrate. Just by dipping a flat silicon (Si) wafer into an aqueous deposition solution of hydrogen fluoride (HF) + silver nitrate (AgNO3), a monolayer of Ag NPs was uniformly deposited onto the Si wafer surface. In order to load the to-be-detected sample onto the as-prepared SERS substrate, three methods have been individually tested, (i) by incubating the SERS substrate in the sample solution, (ii) by dropping and drying a small volume of the sample solution (1-2 microl) onto the SERS substrate surface, or (iii) by directly introducing the sample into the deposition solution. The last approach was also employed to metalize a Si nanowire (NW). Due to the NW's highly curved surface, the Ag NPs self-assembled and aggregated along the NW with a close interdistance. The aggregated Ag NPs on the NW surface can also be used as a SERS substrate. The demonstrated approach holds the promise to prepare a fresh SERS substrate at the point-of-use with the sample already loaded to promptly collect the SERS signal for the field application.
Evaluating the Use of Leaned Stator Vanes to Produce a Non-Uniform Flow Distribution Across the Inlet Span of a Mixed Flow Turbine Rotor (2019)

Abstract Current trends in the automotive industry have placed an increased emphasis on downsized turbocharged engines for passenger vehicles. The turbocharger is increasingly relied upon to improve power output across a wide range of engine operating conditions, placing a greater emphasis on turbocharger offdesign performance. An off-design condition of significant importance is performance at low turbine velocity ratios, since it is relevant to engine transient response and also to efficient energy extraction from pressure pulses in the unsteady exhaust flow. An increased focus has been placed on equipping turbochargers with mixed flow turbine rotors instead of conventional radial flow turbine rotors to improve off-design performance and to reduce rotor inertia. A recognized feature of a mixed flow turbine is the spanwise variation of flow conditions across the blade leading edge. This is a consequence of the reduction in leading edge radius from shroud to hub, coupled with the increasing tangential velocity of the flow due to conserved angular momentum as the radius decreases. The result is increasingly positive incidence towards the hub side of the leading edge. The resulting region of highly positive incidence at the hub produces separation from the suction surface and generates significant loss within the rotor passage. The aim of this study was to determine if the losses in a MFT could be reduced by the use of leaned stator vanes, which deliberately created a significant spanwise variation of flow angle between hub and shroud at rotor inlet, to reduce the positive incidence at the hub. The turbine performance with a series of leaned vanes was compared against that of a straight vane using a validated CFD model. It was found that increasing vane lean improved turbine performance at all operating points considered. An increase of 3.2 percentage points in stage total-to-static efficiency was achieved at a key off-design operating point. Experimental testing of a set of leaned vanes and the baseline vanes confirmed the advantage of the leaned vanes at all operating points, with an increase in measured efficiency of 2.6 percentage points at the key off-design condition. Unsteady CFD models confirmed the same level of improvement at this operating point. The CFD and experimental results confirmed that the losses in a MFT can be reduced by the use of leaned stator vanes to shape the flow at rotor inlet.
Synthetic erythrocytes from lipid encapsulated hemoglobin. (1980)

Synthetic erythrocytes have been formed by encapsulating concentrated hemoglobin solutions in microcapsules consisting of phospholipid-cholesterol mixtures. The microcapsules (hemosomes) are of the order of one micron in diameter or smaller, are osmometers, are somewhat sturdier than erythrocytes (RBC), and are stable upon freezing. They have essentially the same oxygen and carbon dioxide carrying capacity as RBC, and can be tailored to have the same electrokinetic properties. They appear to evoke no immune response in the rat. In experiments involving complete replacement of natural blood hemosomes appear to sustain life. Rats can live and breathe normally without signs of hypoxia or acidosis for extended periods of time after the hematocrit of natural RBC drops well below the critical level. Synthetic erythrocytes do not appear to cause disseminated coagulation, microembolism, or any observable changes in internal organs.
A fully integrated D-band direct-conversion I/Q transmitter and receiver chipset in SiGe BiCMOS technology (2021)

This paper presents design and characterization of single-chip 110–170 GHz (D-band) direct conversion in-phase/quadrature-phase (I/Q) transmitter and receiver monolithic microwave integrated circuits (MMICs), realized in a 130 nm SiGe BiCMOS process with ft/fmax of 250 GHz/370 GHz. The chipset is suitable for low power wideband communication and can be used in both homodyne and heterodyne architectures. The Transmitter chip consists of a six-stage power amplifier, an I/Q modulator, and a LO multiplier chain. The LO multiplier chain consists of frequency sixtupler followed by a two-stage amplifier. It exhibits a single sideband conversion gain of 23 dB and saturated output power of 0 dBm. The 3 dB RF bandwidth is 31 GHz from 114 to 145 GHz. The receiver includes a low noise amplifier, I/Q demodulator and ×6 multiplier chain at the LO port. The receiver provides a conversion gain of 27 dB and has a noise figure of 10 dB. It has 3dB RF bandwidth of 28 GHz from 112–140 GHz. The transmitter and receiver have dc power consumption of 240 mW and 280 mW, respectively. The chip area of each transmitter and receiver circuit is 1.4 mm×1.1 mm.
VirtualDose: a software for reporting organ doses from CT for adult and pediatric patients (2015)

This paper describes the development and testing of VirtualDose--a software for reporting organ doses for adult and pediatric patients who undergo x-ray computed tomography (CT) examinations. The software is based on a comprehensive database of organ doses derived from Monte Carlo (MC) simulations involving a library of 25 anatomically realistic phantoms that represent patients of different ages, body sizes, body masses, and pregnant stages. Models of GE Lightspeed Pro 16 and Siemens SOMATOM Sensation 16 scanners were carefully validated for use in MC dose calculations. The software framework is designed with the 'software as a service (SaaS)' delivery concept under which multiple clients can access the web-based interface simultaneously from any computer without having to install software locally. The RESTful web service API also allows a third-party picture archiving and communication system software package to seamlessly integrate with VirtualDose's functions. Software testing showed that VirtualDose was compatible with numerous operating systems including Windows, Linux, Apple OS X, and mobile and portable devices. The organ doses from VirtualDose were compared against those reported by CT-Expo and ImPACT-two dosimetry tools that were based on the stylized pediatric and adult patient models that were known to be anatomically simple. The organ doses reported by VirtualDose differed from those reported by CT-Expo and ImPACT by as much as 300% in some of the patient models. These results confirm the conclusion from past studies that differences in anatomical realism offered by stylized and voxel phantoms have caused significant discrepancies in CT dose estimations.