gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Addition of Bromine Chloride and Iodine Monochloride to Carbonyl‐Conjugated, Acetylenic Ketones: Synthesis and Mechanisms. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Zinc finger peptide cleavage by a dinuclear platinum compound (2013)

Electrospray ionisation mass spectrometry (ESI-MS) and {(1)H, (15)N HSQC} NMR spectroscopy has elucidated the binding of a dinuclear platinum compound to a zinc finger peptide with induced backbone cleavage. Cleavage is selective on the N-terminal side of the cysteine residue following incubation at neutral pH, and is further dependent on structure of dinuclear compound.
AN FPGA-BASED IMAGE ROTATION TECHNOLOGY (2011)

Image rotation is a common digital image processing technology which is widely applied to various fields.Most digital image display systems scan to refresh images from left to right and from top to bottom;then save them in the same order.The rotation function enables the LCD screen to display images which are rotated by 90°,180°,or 270°.In the software realization technology field there are a lot of researches and applications on image rotation technology.The article proposes a highly adaptive solution on a hardware universal technology platform.
Fractional-order controllers for stick-slip vibration mitigation in oil well drill-strings (2021)

Drillstring–borehole interaction can produce severely damaging vibrations. An example is stick–slip vibration, which negatively affects drilling performance, tool integrity and completion time, and costs. Attempts to mitigate stick–slip vibration typically use passive means and/or change the operation parameters, such as weight on bit and rotational speed. Automating the latter approach, by means of feedback control, holds the promise of quicker and more effective mitigation. The present work presents three separate fractional-order controllers for mitigating drillstring slip–stick vibrations. For the sake of illustration, the drillstring is represented by a torsional vibration lumped parameter model with four degrees of freedom, including parameter uncertainty. The robustness of these fractional-order controllers is compared with traditional proportional-integral-derivative controllers under variation of the weight on bit and the drill bit’s desired rotary speed. The results confirm the proposed controllers effectiveness and feasibility, with rapid time response and less overshoot than conventional proportional-integral-derivative controllers.
Closing the Loop: The Adicol Experience (2004)

The objective of the project Advanced Insulin Infusion using a Control Loop (ADICOL) was to develop a treatment system that continuously measures and controls the glucose concentration in subjects with type 1 diabetes. The modular concept of the ADICOL's extracorporeal artificial pancreas consisted of a minimally invasive subcutaneous glucose system, a handheld PocketPC computer, and an insulin pump (D-Tron, Disetronic, Burgdorf, Switzerland) delivering subcutaneously insulin lispro. The present paper describes a subset of ADICOL activities focusing on the development of a glucose controller for semi-closed-loop control, an in silico testing environment, clinical testing, and system integration. An incremental approach was adopted to evaluate experimentally a model predictive glucose controller. A feasibility study was followed by efficacy studies of increasing complexity. The ADICOL project demonstrated feasibility of a semi-closed-loop glucose control during fasting and fed conditions with a wearable, modular extracorporeal artificial pancreas.
Lack of involvement of the c-fms and N-myc genes by chromosomal translocation t(2;5)(p23;q35) common to malignancies with features of so-called malignant histiocytosis (1989)

We report the molecular, cytogenetic, and immunologic characterization of three hematologic malignancies that contained characteristic t(2;5) chromosomal translocations. The clinicopathologic features in all three cases fit the disease spectrum of so-called malignant histiocytosis (MH). All cases expressed activation antigens including Ki-1 (CD 30), but no lineage-restricted pattern of cellular antigen expression was observed. Cell lines SUP-M2 and SU-DHL-1 established from two of the cases showed rearranged beta T-cell receptor (beta TCR) genes nonproductive of full-length beta TCR mRNA and therefore not helpful in unequivocal establishment of lineage derivation. The common cytogenetic feature was a reciprocal translocation between chromosomes 2 and 5, involving bands 2p23 and 5q35 near the reported chromosomal locations of the N-myc and c-fms genes, respectively. Normal-sized and truncated c-fms RNAs were observed in both cell lines, whereas no N-myc transcripts were detected. Sequence analysis of the truncated fms RNA showed that it consisted of the 3' half of the c-fms mRNA, but its derivation was not the result of a structural alteration of the c-fms gene. Our studies show that the t(2;5) does not involve the N-myc and c-fms protooncogenes and that this cytogenetic abnormality may be characteristic of a subset of primitive malignancies with an indeterminate lineage but with clinicopathologic features of so-called MH.
Intensity constrained flat kernel filter for local dark feature suppression: application to removal of hair artifacts in dermatoscopic images (2012)

The Intensity Constrained Flat Kernel Filtering (ICFK) scheme is a dual domain (spatial and intensity) nonlinear framework which has been shown to generate useful filters for image processing. This paper proposes a new filter developed within the ICFK framework. Although local in nature the filter is designed to suppress large scale spatial features within the image. As in every other filter derived within the scheme the suppressed features are defined by two parameters: size of the kernel and intensity range. The filter, a single-step procedure, is applied to removal of hair artifacts in skin lesion epiluminescence microscopy images, the task essential in assisting in automated segmentation of imaged area into lesion and surrounding skin. Results of the experiments on 400 dermatoscopic images of lesions with hair indicate suitability of the method as an aid in lesion segmentation by suppressing hair or vascular features near the lesion borders.
Membrane-type matrix metalloproteinases: Their functions and regulations (2015)

Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further sub-classified into type I transmembrane-type (MT1, -MT2-, MT3- and MT5-MMPs) and glycosylphosphatidylinositol (GPI)-anchored type (MT4- and MT6-MMPs). In either case MT-MMPs are tethered to the plasma membrane, and this cell surface expression provides those enzymes with unique functionalities affecting various cellular behaviours. Among the 6 MT-MMPs, MT1-MMP is the most investigated enzyme and many of its roles and regulations have been revealed to date, but the potential roles and regulatory mechanisms of other MT-MMPs are gradually getting clearer as well. Further investigations of MT-MMPs are likely to reveal novel pathophysiological mechanisms and potential therapeutic strategies for different diseases in the future.
An FTIR–ATR investigation of in vivo poly(ether urethane) degradation (1992)

Abstract Surface degradation of implanted poly(ether urethane)s was studied quantitatively with a micro‐ATR–FTIR technique. Substantial degradation was observed particularly in the soft segment at the α‐carbon adjacent to the ether linkage. The degradation caused changes in the concentration profiles of the soft‐segment groups in the depth direction, and the affected depth was up to 10 microns after implantation for 10 weeks. Inhibition of degradation by antioxidants indicated the oxidative nature of degradation. An in vivo poly(ether urethane) degradation mechanism was proposed.
A soft-biometrics dataset for person tracking and re-identification (2014)

In this work we present a new dataset for the tasks person detection, tracking, re-identification, and soft-biometric attribute detection in surveillance data. The dataset was recorded over three days and consists of more than 30 individuals moving through a network of seven cameras. Person tracks are labeled with consistent IDs as well as soft-biometric attributes, such as a description of the clothing, gender, or height. Persons in the video data alter their appearance by changing clothes or wearing accessories. A second, clothing specific ID of each track allows for the evaluation of re-identification with or without the presence of clothing changes. In addition to video and camera calibration data, we provide evaluation protocols, tools and baseline results for each of the four tasks.
Phase II trial of combination treatment with paclitaxel, carboplatin and cetuximab (PCE) as first-line treatment in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (CSPOR-HN02) (2018)

UMIN000010507.
Spectroscopic Characterization of Inorganic and Organometallic Complexes by Metal and High-Pressure NMR (1987)

Practical guidelines are offered for obtaining NMR spectra either of metals or of samples which are subjected to conditions of high pressure. Both techniques are becoming routinely available as a means for characterizing organometallic complexes. Applications of metal NMR are no longer limited to static characterization in terms of sample homogeneity or trends in chemical shift. Examples are drawn to emphasize structural characterization and dynamic studies. A novel sapphire NMR tube is described which permits routine high resolution operation up to 2,000 psi. The tubes can be used in any spectrometer, and have allowed the study of fundamental reactions of transition metal carbonyl complexes under conditions which would otherwise bring about sample decomposition.
A Randomized, Double-Blind, Placebo-Controlled 8-Week Trial of the Efficacy and Tolerability of Multiple Doses of Lu AA21004 in Adults With Major Depressive Disorder (2012)

ClinicalTrials.gov identifier: NCT00735709.
La dilatation de l'orifice de sphinctérotomie pour l'ablation de volumineux calculs biliaires est-elle possible dans le même temps endoscopique que la sphinctérotomie? (2012)

La dilatation de l'orifice de sphinctérotomie (SE) a été proposée pour permettre l'ablation de volumineux calculs (diamètre >15mm) de la voie biliaire principale (VBP), le plus souvent après échec de l'extraction au ballonnet ou de la lithotritie. La dilatation est alors réalisée lors d'un deuxième cathétérisme de papille (CPRE). Le but de notre étude était d'évaluer la possibilité de réaliser une dilatation large de l'orifice de sphinctérotomie dans le même temps endoscopique, chez des patients présentant un ou plusieurs volumineux calculs de la VBP et des comorbidités justifiant de limiter le nombre et la durée des anesthésies.
Cerebral infarcts in patients with autopsy-proven Alzheimer's disease (1998)

The clinical-neuropathologic correlations in CERAD patients generally confirm those in prior studies, indicating that the presence of cerebral infarction in patients with AD is associated with greater overall severity of clinical dementia and poorer performance on specific tests of language and cognitive function.
Electromechanical Properties of Order-Disorder Type Ferroelectrics. II. Electrostriction (1977)

The static and dynamic electrostrictive properties of order-disorder type ferroelectrics are discussed. The theory takes into account properly the role of an ionic polarization which interacts with a dipole system. The electrostrictive constants M and Q with which the electrostrictive contribution to the total strain is written as M E 2 or Q P 2 are calculated. The constant M diverges when T C is approached from above as well as from below, its sign below T C being opposite to that above T C . The constant Q shows a marked temperature dependence in the ferroelectric phase. Besides, it shows a sharp cusp at T C when the Curie constant is small. The electrostrictive strain under an alternating electric field is expected to show an anomalous phase lag. All these are due to the dielectric nonlinearity and/or the presence of an ionic polarization. When the ionic polarization is ignored, the result reduces to that of Landau-Devonshire theory.
Hybrid organic-inorganic light emitting diode using ZnO nanorods as electron transport layer (2013)

We have successfully synthesized hybrid organic-inorganic light emitting diode using ZnO nanorods as the electron transport layer and MEH-PPV as the emitting layer. The ZnO nanorods were synthesized using self-catalyzed thermal chemical vapor deposition method. The current density-voltage curves prove that the conductivity of the ZnO nanorods was improved. The turn on voltage was reduced from 2V to 0.4V with the insertion of ZnO nanorods between the cathode and emissive layer. Sharp visible emissions centred at 540 and 580 nm were observed from the electroluminescence spectra under forward biasing. A broad emission at 590 nm with a shoulder peak at 640 nm was also detected.
[Construction and identification of luciferase and EGFP expression vectors containing human IFN-β promoter]. (2014)

The recombinant vectors pGL3-IFNB1 and pGE3-IFNB1 containing IFN-β promoter have been successfully constructed. It provides useful tools for further study on the mechanism of IFN-β production induced by virus.
Traction injury of common peroneal nerve associated with multiple ligamentous rupture of the knee: A case report (2002)

We report on a case of a 19-year-old male student who sustained a hyperextension injury to his left knee while playing rugby, which resulted in a traction injury of the common peroneal nerve and multiple ligamentous injuries at the knee joint. The damaged part of the common peroneal nerve was resected, and an end-to-end suture was performed, because the gap between the nerve ends was small enough to allow closure with little mobilization. Now, 2.5 years after the surgery, the patient shows remarkable recovery. This result suggests that end-to-end suture is an ideal procedure for nerve traction injury, if the nerve ends can be closed without tension, without excessive flexion of the adjacent joint.
Spatial and Functional Relationship of GGAs and AP‐1 in Drosophila and HeLa Cells (2009)

The GGAs [Golgi-localised, gamma-ear containing, ARF (ADP ribosylation factor)-binding proteins] and the AP-1 (adaptor protein-1) complex are both adaptors for clathrin-mediated intracellular trafficking, but their relationship to each other is unclear. We have used two complementary systems, HeLa cells and Drosophila Dmel2 cells, to investigate GGA and AP-1 function. Immunoelectron microscopy of endogenous AP-1 and GGA in Dmel2 cells shows that they are predominantly associated with distinct clathrin-coated structures. Depletion of either GGA or AP-1 by RNAi does not affect the incorporation of the other adaptor into clathrin-coated vesicles (CCVs), and the cargo protein GFP-LERP (green fluorescent protein-lysosomal enzyme receptor protein) is lost from CCVs only when both adaptors are depleted. Similar results were obtained using HeLa cells treated with siRNA to deplete all three GGAs simultaneously. AP-1 was still incorporated into CCVs after GGA depletion and vice versa, and both needed to be depleted for a robust inhibition of receptor-mediated sorting of lysosomal hydrolases. In contrast, downregulation of major histocompatibility complex (MHC) class I by HIV-1 Nef, which requires AP-1, was not affected by a triple GGA knockdown. Thus, our results indicate that the two adaptors can function independently of each other.
Apoptosis (cell death) induced in mouse bowel by 1,2-dimethylhydrazine, methylazoxymethanol acetate, and gamma-rays. (1989)

Apoptosis is a pattern of cell death involving nuclear pyknosis, cytoplasmic condensation, and karyorrhexis. The frequency of apoptosis after treatment with two colon carcinogens and radiation was studied in the crypts of five different portions of mouse bowel. When 1,2-dimethylhydrazine (DMH) was injected s.c., the earliest rise in apoptotic incidence after a high dose (200 mg/kg) was noted at 3 h in small intestine and at 6 h in large bowel. After i.p. administration of methylazoxymethanol (MAM) acetate, apoptotic cells were seen in large bowel after 3 h. When the plateau values attained after high doses of DMH were compared, many apoptotic cells were found in the lower part of the large bowel, whereas few such cells were observed in the small intestine and the upper part of the large bowel. This finding was reversed in the case of radiation-induced apoptosis. In the descending colon, a definite circadian rhythm in the apoptotic incidence was observed 6 h after injection of DMH or MAM acetate. Apoptosis showed a high incidence when these drugs were given between 2400 h and 0900 h, but a low incidence after administration between 1200 h and 2100 h. In the small intestine a rhythm was also noted for MAM acetate, but not significantly for DMH.
The zebrafish's swim to fame as an experimental model in biology (1997)

The zebrafish has long been the favorite organism in many scientific disciplines. Although its attributes as a model were expounded for many years and thus were no secret, the zebrafish sat in the wings while other more popular vertebrates such as chick, amphibians, and mouse were examined at length. We cannot say there was a resurgence in popularity, but more an explosion of research utilizing the zebrafish beginning in the late 1970s when investigators at the University of Oregon began using it as their model in neuroscience. Prior to this reawakening, the zebrafish was one of the significant organisms in the study of teratology and toxicology, development, and, to some extent, behavior. Recently, however, the field of zebrafish genetics has gained immense popularity and success, in part owing to the fact that zebrafish are diploid and are amenable to genetic manipulations. Here we present an overview of the multidisciplinary research that has laid some of the foundation of our present understanding of the biochemical, cell biological, and molecular genetic events accompanying zebrafish development.
A reconfigurable 16-channel HV stimulator ASIC for Spinal Cord Stimulation systems (2012)

A 16-channel stimulation waveform generator ASIC using high voltage CMOS technology to generate high voltage stimulation signals for Spinal Cord Stimulation (SCS) systems is presented in this study. To enlarge the voltage swing on high-impedance electrodes, the output stage of the proposed for the SCS systems is implemented on silicon using a 0.25 μm high-voltage (60 V) devices. Particularly, a charge pump composed of 5 cascaded voltage doublers is used to boost the core voltage (2.5 V) to higher than 10 V required by the SCS systems to execute electrical stimulation therapy [1]. A total of 16 stimulation waveform generators are included to drive 16 sets of electrodes, where each generator is composed of an HV operational amplifier and an HV analog switch. Compared with existing commercial products, the proposed SCS system attains better flexibility to meet the spinal cord stimulation high voltage demand in addition to the reduction of cost and PCB size.
Specific-to-General Learning for Temporal Events with Application to Learning Event Definitions from Video (2002)

We develop, analyze, and evaluate a novel, supervised, specific-to-general learner for a simple temporal logic and use the resulting algorithm to learn visual event definitions from video sequences. First, we introduce a simple, propositional, temporal, event-description language called AMA that is sufficiently expressive to represent many events yet sufficiently restrictive to support learning. We then give algorithms, along with lower and upper complexity bounds, for the subsumption and generalization problems for AMA formulas. We present a positive-examples--only specific-to-general learning method based on these algorithms. We also present a polynomial-time--computable ``syntactic'' subsumption test that implies semantic subsumption without being equivalent to it. A generalization algorithm based on syntactic subsumption can be used in place of semantic generalization to improve the asymptotic complexity of the resulting learning algorithm. Finally, we apply this algorithm to the task of learning relational event definitions from video and show that it yields definitions that are competitive with hand-coded ones.
Intermediate instability at high temperature leads to low pathway efficiency for an in vitro reconstituted system of gluconeogenesis in Sulfolobus solfataricus (2013)

Four enzymes of the gluconeogenic pathway in Sulfolobus solfataricus were purified and kinetically characterized. The enzymes were reconstituted in vitro to quantify the contribution of temperature instability of the pathway intermediates to carbon loss from the system. The reconstituted system, consisting of phosphoglycerate kinase, glyceraldehyde 3-phosphate dehydrogenase, triose phosphate isomerase and the fructose 1,6-bisphosphate aldolase/phosphatase, maintained a constant consumption rate of 3-phosphoglycerate and production of fructose 6-phosphate over a 1-h period. Cofactors ATP and NADPH were regenerated via pyruvate kinase and glucose dehydrogenase. A mathematical model was constructed on the basis of the kinetics of the purified enzymes and the measured half-life times of the pathway intermediates. The model quantitatively predicted the system fluxes and metabolite concentrations. Relative enzyme concentrations were chosen such that half the carbon in the system was lost due to degradation of the thermolabile intermediates dihydroxyacetone phosphate, glyceraldehyde 3-phosphate and 1,3-bisphosphoglycerate, indicating that intermediate instability at high temperature can significantly affect pathway efficiency.
Note: Gratings on low absorbing substrates for x-ray phase contrast imaging (2015)

Grating based X-ray phase contrast imaging is on the verge of being applied in clinical settings. To achieve this goal, compact setups with high sensitivity and dose efficiency are necessary. Both can be increased by eliminating unwanted absorption in the beam path, which is mainly due to the grating substrates. Fabrication of gratings via deep X-ray lithography can address this issue by replacing the commonly used silicon substrate with materials with lower X-ray absorption that fulfill certain boundary conditions. Gratings were produced on both graphite and polymer substrates without compromising on structure quality. These gratings were tested in a three-grating setup with a source operated at 40 kVp and lead to an increase in the detector photon count rate of almost a factor of 4 compared to a set of gratings on silicon substrates. As the visibility was hardly affected, this corresponds to a significant increase in sensitivity and therefore dose efficiency.