gebhart/patrepeval huggingface dataset:
Tactile stimulus is essential to increase motivation for touch interaction in virtual environment (2021)

This paper reports the effectiveness of a tactile stimulus in a virtual environment to increase people's motivations during a monotonous task by comparing a touch with only visual stimuli and another with both visual and tactile stimuli. Although touch interaction with robots showed various positive effects such as improved motivation, visual and haptic stimuli were not separated due to the form of the touch in physical environments. Virtual environments enable us to investigate such effects by separating the modality of touch: a visual-only-touch and a visual-tactile touch. We experimented in a virtual environment where participants did a monotonous task after experiencing either a visual-only-touch or a visual-tactile-touch by an agent to compare them in the context of motivation improvements and the perceived impressions. The experimental results showed that a visual-tactile touch significantly increases the motivations of the participants for monotonous tasks. On the other hand, their likability of the agents is not significantly changed by the touch modalities.
Trastorno dismórfico corporal con desenlace fatal: reporte de un caso (2011)

Se presenta el caso de un varón joven con trastorno dismórfico corporal quien, como consecuencia de su padecimiento, permaneció aislado en su domicilio durante tres años, con deterioro importante de su funcionalidad, y acabó finalmente suicidándose. El trastorno dismórfico corporal es una patología subdiagnosticada, de pronóstico y tratamiento complejos, que debe ser considerado como diagnóstico diferencial en diversas dolencias psiquiátricas, quejas dermatológicas y de cirugía cosmética.
GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice (2021)

Abstract Previous studies suggest that signaling by the gamma-aminobutyric acid (GABA) type B receptor (GABA B R) is involved in the regulation of binge eating, a disorder which might contribute to the development of obesity. Here, we show that intermittent access to a high fat diet (HFD) induced binge-like eating behavior with activation of dopamine receptor d1 (drd1)-expressing neurons in the caudate putamen (CPu) and nucleus accumbens (NAc) in wild-type (WT) mice. The activation of drd1-expressing neurons during binge-like eating was substantially increased in the CPu, but not in the NAc, in corticostriatal neuron-specific GABA B R-deficient knockout (KO) mice compared to WT mice. Treatment with the GABA B R agonist, baclofen, suppressed binge-like eating behavior in WT mice, but not in KO mice, as reported previously. Baclofen also suppressed the activation of drd1-expressing neurons in the CPu, but not in the NAc, during binge-like eating in WT mice. Thus, our data suggest that GABA B R signaling in CPu neurons expressing drd1 suppresses binge-like consumption during a HFD in mice.
The role of cysteine residues in the folding and association of the COOH-terminal propeptide of types I and III procollagen. (1994)

Procollagen chains assemble in a type-specific manner forming either homo- or heterotrimers. The molecular mechanisms underlying procollagen chain selectivity are unknown, although it is thought that the C-propeptide (COOH-terminal propeptide) is responsible for directing chain recognition and assembly. To define the processes involved in chain selection we reconstituted the initial stages of procollagen folding and assembly in a cell-free system. Using human pro-alpha 1(III) and pro-alpha 2(I) chains as prototypes of chains that are either capable or incapable of forming homotrimeric molecules, respectively, we constructed two minigenes (p alpha 1(III) delta 1 and p alpha 2(I) delta 1) that lacked most of the triple helical domains. The minigenes were transcribed in vitro and translated in a rabbit reticulocyte lysate supplemented with microsomal membranes under conditions that favored disulfide bond formation. Both pro-alpha 1(III) delta 1 and pro-alpha 2(I) delta 1 chains formed intrachain disulfide bonds within the C-propeptide. However, only pro-alpha 1(III) delta 1 chains were able to self-associate forming homotrimers stabilized by interchain disulfide bonds. The C-propeptide of the pro-alpha 1(III) chain contains 8 cysteine residues (Cys-1-8). We used a site-directed mutagenesis to investigate the role of specific cysteine residues in trimer formation and found that substitution of serine for Cys-1, Cys-2, Cys-3, and Cys-4 prevented interchain disulfide bonding and trimerization. Furthermore, mutations in Cys-1 and Cys-4 also prevented intrachain disulfide bond formation within the C-propeptide. The C-propeptide of the pro-alpha 2(I) chain contains only 7 cysteine residues, lacking cysteine at position 2. Substitution of the existing Ser residue with Cys did not produce a homotrimeric phenotype, indicating that additional recognition signals are required to determine chain selection.
Micelles of Amphiphilic Diblock and Triblock Copolymers Based on Poly(ethylene oxide) and Poly(e-caprolactone) and Their Potential as Nanocontainers for Drugs (2012)

The amphiphilic MOPEO-b-PCL copolymers with biocompatible and biodegradable blocks in selective solvent form micelles of spherical and uncommon ellipsoidal morphology, which size and stability increase with the lengthening of “core”-forming hydrophobic PCL block. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/34800
Key to nine ubiquitous soil-borne Phoma-like fungi (1970)

The differentiating characteristics on agar-media of Pyrenochaeta acicola, Phoma chrysanthemicola, P. eupyrena, P. fimeti, P. glomerata, P. herbarum, P. medicaginis var. pinodella, and P. prunicola are discussed and illustrated. In a supplementary note the nomenclature of Pyrenochaeta acicola, Phoma chrysanthemicola, P. eupyrena, and P. fimeti is recorded.
Deformable mems grating for wide tunability (2006)

A deformable MEMS grating is presented. Electrostatic actuation allows a per cent tuning of up to 2.5%. This device can be used as tuning element in an external cavity mid-infrared quantum-cascade laser
CK-MB isoforms for early risk stratification of emergency department patients (2000)

The potential clinical utility of single sample CK-MB isoforms measurement for early risk stratification of Emergency Department (ED) patients with possible myocardial ischemia was evaluated among 405 patients presenting to two urban EDs. Clinical and serologic data were prospectively collected and the occurrence of adverse events (AEs) and myocardial infarction (MI) during the 14-day outcome period was recorded and utilized to calculate and compare relative risks (RR) and predictive values of isoforms and CK-MB alone. Among the 405 patients, 67 accrued 105 AEs. Both isoforms and CK-MB alone were predictive of AEs with RR of 3.32 (2.09, 5.27) and 6.28 (4.64, 8.52), respectively. Isoforms had higher sensitivity for AEs compared to CK-MB (65.7% [54.3, 77.0] vs. 14.9% [6.4, 23.5]; p<0. 01) but lower specificity (69.2% [64.3, 74.2] vs. 99.7% [99.1,100. 0]; p<0.01). Isoforms' superior sensitivity allowed identification of many high risk patients missed by CK-MB alone. Further, for the prediction of MI, isoforms had superior diagnostic sensitivity and equivalent specificity. This investigation supports the emergency department use of early, single sample CK-MB isoform testing.
Three‐dimensional structure of the Fab fragment of a neutralizing antibody to human rhinovirus serotype 2 (1992)

The crystal structure of the antigen-binding fragment of a monoclonal antibody (8F5) that neutralizes human rhinovirus serotype 2 has been determined by X-ray diffraction studies. Antibody 8F5, obtained by immunization with native HRV2 virions, cross-reacts with peptides of the viral capsid protein VP2, which contribute to the neutralizing immunogenic site B in this serotype. The structure was solved by the molecular replacement method and has been refined to an R-factor of 18.9% at 2.8 A resolution. The elbow angle, relating the variable and constant modules of the molecule is 127 degrees, representing the smallest elbow angle observed so far in an Fab fragment. Furthermore, the charged residues of the epitope can be well accommodated in the antigen-binding site. This is the first crystal structure reported for an antibody directed against an icosahedral virus.
Comparison between theory and experiment in self-pumped Brillouin-enhanced four-wave mixing (1989)

We report on a theoretical and modeling study of self-pumped four-wave mixing in a Brillouin medium. A theoretical analysis gives expressions for the threshold intensity and for the steady-state reflectivity at small input intensities. Operation over a range of input intensities is also investigated by using a computer model that predicts that, for high input intensities, the conjugate can become unstable and oscillate chaotically in time. Experimentally we observe phase conjugation with an input threshold 25 times less than that required for phase conjugation by stimulated Brillouin scattering.
New Molecular Metals Based on a Tetrathiapentalene Donor with Peripheral Methoxy Groups (2010)

Abstract A new tetrathiapentalene (TTP) donor 2-(4,5-dimethoxy-1,3-dithiol-2-ylidene)-5-(1,3-dithiol-2-ylidene)-1,3,4,6-tetrathiapentalene (DMO-TTP) has been synthesized, and the PF6 and AsF6 salts have also been prepared by electrochemical crystallization. X-ray structure analyses have revealed that intermolecular and intramolecular CH···O hydrogen bondings are constructed in the neutral crystal and the cation radical salts, respectively. The PF6 and AsF6 salts have a so-called β-type arrangement of the donors and show metallic behavior down to around 10 K.
Demonstration of completely organic, optically clear radioluminescent light (1989)

A new type of radioluminescent light source has been demonstrated. This all-organic system consists of covalently bound tritium within a solid, optically clear polymeric matrix. The matrix contains a set of organic luminophores that capture excitation energy from beta decay and red shift the energy in a stepwise fashion, after which a chosen wavelength is emitted as fluorescence. Both blue and orange lights have been fabricated. Unlike currently available tritium gas tube lights or radioluminescent paints, the brightness of these new systems is, in principle, scalable because self-attenuation and absorption effects are minimized.
Low-Activation Multilayer Shielding Structure of Light Water Reactor Using Various Types of Low-Activation Concrete (2011)

Low-activation multilayer shielding structure of light water reactor has been designed using various types (1/10, 1/100, 1/1,000 and 1/10,000) of low-activation concrete composed of low-activation raw materials. The term "1/10 of low-activation concrete" denotes that the activity reduction rate to ordinary concrete is designed to be 1/10. As an example, iterative calculations of induced activities and Di/Ci (Di: concentration of radionuclide i, Ci: clearance level of radionuclide i) values of multilayer model for the Japan Power Demonstration Reactor (JPDR) have been performed by using a discrete ordinate code. It is concluded that most of the shielding concrete of JPDR would be classified below clearance level on decommissioning by adopting such low-activation multilayer shielding structures.
Port Site Fascia Closure in Laparoscopic Assisted Colectomy: A Simple Technique (1995)

The importance of port site fascia closure after laparoscopic procedures has been recently recognized as an increasing number of port site hernias have been reported. We present a simple technique of port site closure after laparoscopic-assisted colon resections.
Interference exploitation for radar and cellular coexistence - the power-efficient approach (2017)

This article consists of a collection of slides from the author's conference presentation. We design a power efficient optimization-based beamforming technique for the coexistence of MIMO radar and downlink MU-MISO communication based on exploiting the constructive interference power, where two optimization problems are formulated: a) Power minimization and b) Interference minimization. We develop an efficient gradient projection algorithm for the power minimization problem. We analytically derive the detection probability for MIMO radar when the proposed beamforming scheme is used. Numerical simulations show that the proposed approach outperforms the conventional SDR-based method significantly.
MOLECULAR MECHANISMS IN PHOTODYNAMIC ACTION† (1969)

Abstract— Photodynamic action can be considered at the molecular level as a dye‐sensitized photoautoxidation of the biological substrate. Recent work has shown that interactions of a sensitizing dye, such as occur in aggregation or binding, can lead to significant changes in its photochemical reactivity. The possible role of such effects in the primary photodynamic mechanism is reviewed.
Supercritical Fluid Technology for the Development of 3D Printed Controlled Drug Release Dosage Forms (2021)

Supercritical CO<sub>2</sub> loading of preformed 3D printed drug carriers with active pharmaceutical ingredients (APIs) shows great potential in the development of oral dosage forms for future personalized medicine. We designed 3D printed scaffold like drug carriers with varying pore sizes made from polylactic acid (PLA) using a fused deposition modelling (FDM) 3D printer. The 3D printed drug carriers were then loaded with Ibuprofen as a model drug, employing the controlled particle deposition (CPD) process from supercritical CO<sub>2</sub>. Carriers with varying pore sizes (0.027-0.125 mm) were constructed and loaded with Ibuprofen to yield drug-loaded carriers with a total amount of 0.83-2.67 mg API (0.32-1.41% <i>w</i>/<i>w</i>). Dissolution studies of the carriers show a significantly decreasing dissolution rate with decreasing pore sizes with a mean dissolution time (MDT) of 8.7 min for the largest pore size and 128.2 min for the smallest pore size. The API dissolution mechanism from the carriers was determined to be Fickian diffusion from the non-soluble, non-swelling carriers. Using 3D printing in combination with the CPD process, we were able to develop dosage forms with individually tailored controlled drug release. The dissolution rate of our dosage forms can be easily adjusted to the individual needs by modifying the pore sizes of the 3D printed carriers.
Technique, rationale, and usefulness of bedside right heart catheterization in critically ill cardiac patients. (1970)

These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California, San Francisco. Taken from transcriptions, they are prepared by Drs. Martin J. Cline and Hibbard E. Williams, Associate Professors of Medicine, under the direction of Dr. Lloyd H. Smith, Jr., Professor of Medicine and Chairman of the Department of Medicine.
Intronic Positioning Maximizes Co-expression and Co-amplification of Nonselectable Heterologous Genes (1989)

The overproduction of heterologous gene products in mammalian cells is often a prerequisite for studies of protein structure, function, and therapeutic efficacy. We report that recombinant fusion of a nonselectable reporter template into the intronic sequences of an amplifiable minigene gives dramatically enhanced co-expression efficiency in stable, primary transformants. Further incremental selective pressure for marker gene amplification results in the rapid acquisition of very high expression levels from the intronically positioned reporter. Nested within a constitutively expressing gene, these templates can be independently regulated at moderate gene dosage levels. Intronic positioning may therefore be of general utility for a variety of recombinant studies.
Immunoglobulins of rnu/rnu 'nude' rats with congenital aplasia of the thymus. (1983)

The levels of immunoglobulins (Ig) in the serum and saliva of nude (rnu/rnu) congenitally athymic rats and control (rnu/+) thymic heterozygous rats have been studied. Serum IgM, and serum and salivary IgA levels were virtually identical between rnu/rnu and rnu/+ rats. Serum IgG was drastically reduced in nude rats during the period when endogenous IgG synthesis was predominant. The most consistent and pronounced differences in Ig levels between rnu/rnu and rnu/+ rats involved the IgG isotype.
Colloidal metal particles as probes of nanoscale thermal transport in fluids (2002)

We investigate suspensions of 3--10 nm diameter Au, Pt, and AuPd nanoparticles as probes of thermal transport in fluids and determine approximate values for the thermal conductance G of the particle/fluid interfaces. Subpicosecond $\ensuremath{\lambda}=770\mathrm{nm}$ optical pulses from a Ti:sapphire mode-locked laser are used to heat the particles and interrogate the decay of their temperature through time-resolved changes in optical absorption. The thermal decay of alkanethiol-terminated Au nanoparticles in toluene is partially obscured by other effects; we set a lower limit $G&gt;20\phantom{\rule{0ex}{0ex}}{\mathrm{MW}\mathrm{m}}^{\ensuremath{-}2}{\mathrm{K}}^{\ensuremath{-}1}.$ The thermal decay of citrate-stabilized Pt nanoparticles in water gives $G\ensuremath{\approx}130{\mathrm{MW}\mathrm{m}}^{\ensuremath{-}2}\phantom{\rule{0ex}{0ex}}{\mathrm{K}}^{\ensuremath{-}1}.$ AuPd alloy nanoparticles in toluene and stabilized by alkanethiol termination give $G\ensuremath{\approx}5{\mathrm{MW}\mathrm{m}}^{\ensuremath{-}2}\phantom{\rule{0ex}{0ex}}{\mathrm{K}}^{\ensuremath{-}1}.$ The measured G are within a factor of 2 of theoretical estimates based on the diffuse-mismatch model.
G040072 Analysis of Gold Foil Cutting Motion in "Kirikane" Craftsman (2011)

\"Kirikane\" is a traditional decorative techniques using metal foil cut into long thin strips, triangles, and squares. Today, traditional arts are facing on difficulties of finding successors. Especially, Kirikane, needs successors. Finding out the secrets help craftsmans to hand down the tacit knowledge and groom successors easily and quickly. The purpose of this study is finding out the "Kirikane" craftsmans' tacit knowledge by using motion analysis technology. In this study, we aimed at "Hakukiri", cutting foil, and found that "Kirikane" craftsman do the same motion regardless of the thickness of the cut foil.
Alpha linolenic acid rich oils. Composition of Plukenetia volubilis (Sacha Inchi) oil from Peru (2006)

In this short paper the oil obtained from the Plukenetia volubilis seeds, a plant belonging to the family of Euphorbiaceae, is described. This crop is cultivated in several Countries of South America. For P volubilis oil numerous classical chemical parameters were evaluated. The obtained data indicate that this oil can be classified as rich in alpha linolenic acid (> 50 %). For the commercial development of this product all available precautions must be taken to avoid or to slow down the oxidative degradation.
NUDT15 genotype distributions in the Korean population (2017)

Thiopurines have a narrow therapeutic range because of frequent toxicity (i.e. marrow suppression), which is only partly explained by TPMT genetic polymorphisms, especially within Asian populations. Recent studies have identified NUDT15 variation as another important factor affecting thiopurine metabolism. In this study, a total of four NUDT15 coding variants (p.Arg139Cys, p.Arg139His, p.Val18Ile, and p.Val18_Val19insGlyVal) were genotyped in 920 Korean individuals using direct sequencing of NUDT15 for the first time in a Korean population. The allele frequencies were 86.7% for NUDT15*1, and 4.4, 6.9, 0.4, 1.1, and 0.50% for *2, *3, *4, *5, and *6, respectively. The NUDT15 phenotypes based on diplotypes included normal activity (n=692), intermediate activity (n=209), and low activity (n=19), occurring in 75.2, 22.7, and 2.1% of the population, respectively. This study was the first to report NUDT15 variants other than NUDT15*3 in the Korean population and more individuals who were categorized as having intermediate or low NUDT15 activity in our study than in previously reported studies in the Korean population (24.8 vs. 19.4%, P<0.05). This study is useful for future clinical studies on thiopurine pharmacogenetics and dosage adjustment in the Korean population.
Tracing early stages of species differentiation: Ecological, morphological and genetic divergence of Galápagos sea lion populations (2008)

Our results suggest a key role of intra- as well as inter-specific niche segregation in the evolution of genetic structure among populations of a highly mobile species under conditions of free movement. Given the monophyletic arrival of the sea lions on the archipelago, our study challenges the view that geographical barriers are strictly needed for the build-up of genetic divergence. The study further raises the interesting prospect that in social, colonially breeding mammals additional forces, such as social structure or feeding traditions, might bear on the genetic partitioning of populations.
Detecting Flying Objects Using a Single Moving Camera (2016)

We propose an approach for detecting flying objects such as Unmanned Aerial Vehicles (UAVs) and aircrafts when they occupy a small portion of the field of view, possibly moving against complex backgrounds, and are filmed by a camera that itself moves. We argue that solving such a difficult problem requires combining both appearance and motion cues. To this end we propose a regression-based approach for object-centric motion stabilization of image patches that allows us to achieve effective classification on spatio-temporal image cubes and outperform state-of-the-art techniques. As this problem has not yet been extensively studied, no test datasets are publicly available. We therefore built our own, both for UAVs and aircrafts, and will make them publicly available so they can be used to benchmark future flying object detection and collision avoidance algorithms.
Biases in small RNA deep sequencing data (2013)

High-throughput RNA sequencing (RNA-seq) is considered a powerful tool for novel gene discovery and fine-tuned transcriptional profiling. The digital nature of RNA-seq is also believed to simplify meta-analysis and to reduce background noise associated with hybridization-based approaches. The development of multiplex sequencing enables efficient and economic parallel analysis of gene expression. In addition, RNA-seq is of particular value when low RNA expression or modest changes between samples are monitored. However, recent data uncovered severe bias in the sequencing of small non-protein coding RNA (small RNA-seq or sRNA-seq), such that the expression levels of some RNAs appeared to be artificially enhanced and others diminished or even undetectable. The use of different adapters and barcodes during ligation as well as complex RNA structures and modifications drastically influence cDNA synthesis efficacies and exemplify sources of bias in deep sequencing. In addition, variable specific RNA G/C-content is associated with unequal polymerase chain reaction amplification efficiencies. Given the central importance of RNA-seq to molecular biology and personalized medicine, we review recent findings that challenge small non-protein coding RNA-seq data and suggest approaches and precautions to overcome or minimize bias.