gebhart/patrepeval huggingface dataset:
Oxidative signalling and inflammatory pathways in Alzheimer's disease (2000)

Conference Abstract| February 01 2000 Oxidative signalling and inflammatory pathways in Alzheimer's disease J.C. Barnes; J.C. Barnes *Glaxo Wellcome Medicines Research Centre, Gunnel's Wood Road, Stevenage, Herts, UK, SG1 2NY Search for other works by this author on: This Site PubMed Google Scholar C. Adinolfi; C. Adinolfi +Eukarion Inc., 6F Alfred Circle, Bedford, MA 01730 Search for other works by this author on: This Site PubMed Google Scholar I. Anderson; I. Anderson ^Cambridge Antibody Technology, The Science Park, Melbourn, Cambs, UK, SG8 6JJ Search for other works by this author on: This Site PubMed Google Scholar S. Doctrow; S. Doctrow +Eukarion Inc., 6F Alfred Circle, Bedford, MA 01730 Search for other works by this author on: This Site PubMed Google Scholar K. Huffman; K. Huffman +Eukarion Inc., 6F Alfred Circle, Bedford, MA 01730 Search for other works by this author on: This Site PubMed Google Scholar K. Joy; K. Joy *Glaxo Wellcome Medicines Research Centre, Gunnel's Wood Road, Stevenage, Herts, UK, SG1 2NY Search for other works by this author on: This Site PubMed Google Scholar P. Soden; P. Soden *Glaxo Wellcome Medicines Research Centre, Gunnel's Wood Road, Stevenage, Herts, UK, SG1 2NY Search for other works by this author on: This Site PubMed Google Scholar B. Malfroy; B. Malfroy +Eukarion Inc., 6F Alfred Circle, Bedford, MA 01730 Search for other works by this author on: This Site PubMed Google Scholar H.T. Rupniak H.T. Rupniak *Glaxo Wellcome Medicines Research Centre, Gunnel's Wood Road, Stevenage, Herts, UK, SG1 2NY Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (1): A17. https://doi.org/10.1042/bst028a017b Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation J.C. Barnes, C. Adinolfi, I. Anderson, S. Doctrow, K. Huffman, K. Joy, P. Soden, B. Malfroy, H.T. Rupniak; Oxidative signalling and inflammatory pathways in Alzheimer's disease. Biochem Soc Trans 1 February 2000; 28 (1): A17. doi: https://doi.org/10.1042/bst028a017b Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Studies on sperm antigenicity. I. Delayed hypersensitivity to spermatozoa (1973)

Abstract Delayed hypersensitivity to human and guinea pig sperm was demonstrated in guinea pigs of the Rockefeller strain by immunization with H 37 Ra adjuvant. The reaction in vivo was demonstrated by skin testing the animals and in vitro by the capillary method. It was found that the sensitivity is not only directed towards the sensitizing antigen, but also shows cross‐reactivity. Thus, peritoneal exudate cells derived from guinea pigs sensitized to human sperm were inhibited by guinea pig sperm. This cross‐reactivity revealed the possibility of a tissue specific antigen. In addition, supernatants obtained after incubation of the sensitized lymph node cells with the specific antigen were found to be spermatotoxic.
Analysis of Interactions in Fullerene‐solvent‐polymer System by UV‐spectroscopy (2008)

It has been shown that UV‐spectroscopy of fullerene C60 solutions in different solvents as well as of mixed solutions (PS+C60) allows us to reveal particularities of interactions in fullerene‐solvent‐polymer systems. The absorption band with maximum at wave‐length λ∼330 nm is the good proof of such interactions. The possibility of identification of polymer‐fullerene covalent bond by using UV‐spectroscopy has been shown for star‐shaped fullerene‐containing polystyrenes.
Identification of radiation‐sensitive expressed genes in the ICR and AKR/J mouse thymus (2013)

We have investigated radiation-sensitive expressed genes (EGs), their signal pathways, and the effects of ionizing radiation in the thymus of ICR and AKR/J mice. Whole-body and relative thymus weights were taken and microarray analyses were done on the thymuses of high-dose-rate (HDR, (137) Cs, 0.8 Gy/min, a single dose of 4.5 Gy) and low-dose-rate (LDR, (137) Cs, 0.7 mGy/h, a cumulative dose of 1.7 Gy) irradiated ICR and AKR/J mice. Gene expression patterns were validated by quantitative polymerase chain reaction (qPCR). The effect of ionizing radiation on thymus cell apoptosis was measured terminal deoxynucleotidyl-transferase-mediated dUTP-end labeling (TUNEL). LDR-irradiation increased the mean whole-body weight, but decreased the relative thymus weight of AKR/J mice. Radiation-sensitive EGs were found by comparing HDR- and LDR-irradiated ICR and AKR/J mice. qPCR analysis showed that 12 EGs had dose and dose-rate dependent expression patterns. Gene-network analysis indicated that Ighg, Igh-VJ558, Defb6, Reg3g, and Saa2 may be involved in the immune response, leukocyte migration, and apoptosis. Our data suggest that expression of the HDR (Glut1, Glut4, and PKLR) and LDR radiation-response genes (Ighg and Igh-VJ558) can be dose or dose-rate dependent. There was an increased number of apoptotic cells in HDR-irradiated ICR mice and LDR-irradiated AKR/J mice. Thus, changes of the mean whole-body weight and relative thymus weight, EGs, signal pathways, and the effects of ionizing radiation on the thymus of ICR and AKR/J mice are described.
Formation of macroscopic organic aggregates (lake snow) in a large lake: The significance of transparent exopolymer particles, plankton, and zooplankton (1997)

Macroscopic organic aggregates (lake snow) were collected and their abundance quantified by scuba divers at a distinct pelagic site in Lake Constance (Germany) at least twice a week throughout the growing season in 1993. Furthermore, concentrations of transparent exopolymer particles (TEP), chlorophyll, particulate organic carbon (POC), and the species composition of phytoplankton and zooplankton in the ambient water were determined. In addition, the formation of aggregates was studied in laboratory experiments by incubating water samples in rolling tanks. The abundance and composition of aggregates showed a pronounced seasonal and vertical pattern in close relation to phytoplankton and zooplankton dynamics and wind conditions. Numbers of aggregates ranged between &lt;1 and 50 liter −1 , with maximum concentrations at 6 m depth in summer and fall. In spring, the peak of TEP concentration occurred simultaneously with that of lake snow, whereas the peaks in summer and fall followed those of aggregate abundance. More detailed analyses indicated that the role of TEP in aggregate formation varies throughout the season. The laboratory experiments revealed an inverse correlation between time of aggregate formation and the concentration of POC. Two different correlations, one for the spring bloom and one for the rest of the year, were established. The results show that multiple mechanisms of aggregate formation occurred throughout the seasons due to variations in source particles and physical conditions.
Supplementary Table from Proteomic Mapping and Targeting of Mitotic Pericentriolar Material in Tumors Bearing Centrosome Amplification (2023)

Supplementary Table from Proteomic Mapping and Targeting of Mitotic Pericentriolar Material in Tumors Bearing Centrosome Amplification
Effect of Various Factors on Degradation of Gelatin in Zn Electrowinning (2012)

The time-dependence of molecular weight of gelatin in Zn electrowinning was investigated by gel permeation chromatography to make clear the effect of various factors on the degradation of gelatin. The molecular weight of gelatin decreased significantly with increasing the time even in the case without electrolysis. Although gelatin acted as a polarizer for Zn deposition, shifting the cathode potential to less noble direction, the polarization effect gradually decreased with time. The decrease in polarization effect of gelatin with time was apparently caused by the decrease in molecular weight due to the degradation. The degradation of gelatin was accelerated with electrolysis, and the degradation was faster at anode than at cathode. However, the difference in degradation rate between anode and cathode was small, showing that the degradation of gelatin was accelerated even at cathode. The observed degradation constant k’ of gelatin for hydrolysis reaction in solution without electrolysis was linearly increased with concentration of sulfuric acid. The degradation constant k’ of gelatin increased significantly with solution temperature, but no k’ depended on the existence of Zn2+, and Cu2+, ions in solution. The linear relationship was observed between lin k’ and 1/T , showing the formation of Arrhenius’ equation. The activation energy for hydrolysis of gelatin in electrowinning solution containing 1.5 mol/dm3 of H2SO4 calculated by the inclination of Arrhenius plot was to be 60.1 kJ·mol-1, and the following equation was derived. k’ =7.4×103 exp(-60.1×103/RT) min-1
Growth of highly conductive Al-rich AlGaN:Si with low group-III vacancy concentration (2021)

The impact of AlGaN growth conditions on AlGaN:Si resistivity and surface morphology has been investigated using metalorganic chemical vapor deposition. Growth parameters including growth temperature, growth rate, and trimethylindium (TMI) flow have been systematically studied to minimize the resistivity of AlGaN:Si. We observed a strong anticorrelation between AlGaN:Si conductivity and growth temperature, suggesting increased silicon donor compensation at elevated temperatures. Secondary ion mass spectrometry and positron annihilation spectroscopy ruled out compensation by common impurities or group-III monovacancies as a reason for the observed phenomenon, in contrast to theoretical predictions. The underlying reason for AlGaN:Si resistivity dependence on growth temperature is discussed based on the possibility of silicon acting as a DX center in Al0.65Ga0.35N at high growth temperatures. We also show remarkable enhancement of AlGaN:Si conductivity by introducing TMI flow during growth. A minimum resistivity of 7.5 mΩ cm was obtained for n-type Al0.65Ga0.35N, which is among the lowest reported resistivity for this composition.
Formulation and characterization of some oil in water cosmetic emulsions based on collagen hydrolysate and vegetable oils mixtures (2019)

Abstract The present study was focused on the preparation and characterization of different topical oil in water emulsions based on natural ingredients such as collagen hydrolysate and vegetable oils mixtures. As oil phases, mixtures of coconut, almond, jojoba, avocado oils (in different ratios) were used while the water phase consisted in lavender water. As emulsifier, a plant based product containing glyceryl stearate and potassium stearate was incorporated (in the concentration range 4–5 %), while as rheology modifier xanthan gum was used (in the concentration range 0.2–1 %). As preservatives, Cosgard (containing benzyl alcohol, salicylic acid, glycerol, ascorbic acid) and mixtures of two essential oils (lemon and lavender) were selected. The designed formulations were assessed by means of their physico-chemical properties (pH, viscosity, thixotropic behavior), optical microscopy analysis and sensorial characteristics. The obtained emulsions were found to present pseudoplastic and thixotropic behaviors, adequate for cosmetic skin care product formulations.
Study of the previous light-soaking effect on annealed hydrogenated polymorphous silicon solar cells structures (2014)

This work describes a study performed on pm-Si:H PIN and NIP structures, deposited by PECVD. We show the effect of light-soaking (AM1.5) on pm-Si:H thin films structures optical properties. We propose a model for long range diffusion of hydrogen through the whole device. From the evolution of Raman spectra after annealing, we show that this long range motion of hydrogen causes a hydrogen rearrangement on the film along with a shift on the exodiffusion peaks explaining the degradation process in this type of devices. As a result we determined that for the PIN structure a hydrogen diffusion barrier is generated by defects, which causes a less degradation of its optoelectronic properties under illumination, and a more stable device during operation is expected.
PERFORMANCE OF AN ABSORPTION/COMPRESSION HEAT PUMP FOR AIR CONDITIONING USING THE SYSTEM WATER-LiBR+LiI+LiNO3+LiCl AS WORKING PAIR (2000)

A new absorption/compression heat pump (ABSOCOMP) for space heating and cooling is being developed under the European Joule Programme. The machine uses water-lithium bromide as working pair and produces ice-slurry at triple point conditions when operates in cooling mode. In this study, the potential of the new multicomponent salt mixture water-LiBr+LiI+LiNO3+LiCl (5:1:1:2 by mol) as working pair was evaluated. An analysis of sensitivity was carried out to study the influence of the absorber temperature on the machine performance in terms of the COP and crystallization risk. Results showed that for the new working pair the cycle can operate at an absorber temperature about 12 °C higher than for water-LiBr, with similar COP values.
Developing a Borehole Miner Extendible-Nozzle Sluicer for Radioactive Waste Dislodging and Retrieval From Underground Storage Tanks (2017)

Radioactive waste resulting from production of weapons is stored at five U.S. Department of Energy (DOE) locations. The waste characteristics range from fluid to sludge to granular salts with radiation levels exceeding 10,000 rad/h. Innovative tools are used to remotely remove the solidified radioactive waste from underground storage tanks. When available, commercial systems are evaluated for waste dislodging and retrieval applications. A waste dislodging and sluicing system developed to dislodge and fracture deposits of ore in underground mining, called a borehole miner, was evaluated by Pacific Northwest National Laboratory (PNNL) and Waterjet Technology, Inc., for removing solidified nuclear waste stored in underground tanks. This compact system may be installed in tanks via small diameter risers and has the capability to both dislodge and retrieve in a single unit. The borehole miner arm includes an extendible nozzle that operates at high pressure using either water or slurry as the dislodging fluid, while providing a focused high-pressure jet to dislodge solidified material. The sluicer nozzle is attached to a retractable arm that can extend and angle to enhance dislodging in specific areas of the tank by changing the standoff distance. This paper describes the borehole miner system and presents results of experiments to evaluate its ability to dislodge solidified saltcake and sludge materials. Tests were conducted with a stationary jet to evaluate the potential to develop an extendible-nozzle borehole miner system for deployment to dislodge radioactive saltcake and sludge wastes stored in underground storage tanks. The tests were successful and identified ranges of parameters for jet diameter and standoff distance applicable for waste remediation. For saltcake simulants, erosion models were developed that represent the data.
Moxifloxacin, Ofloxacin, Sparfloxacin, and Ciprofloxacin against Mycobacterium tuberculosis : Evaluation of In Vitro and Pharmacodynamic Indices That Best Predict In Vivo Efficacy (2006)

Members of the fluoroquinolone class are being actively evaluated for inclusion in tuberculosis chemotherapy regimens, and we sought to determine the best in vitro and pharmacodynamic predictors of in vivo efficacy in mice. MICs for Mycobacterium tuberculosis H37Rv were 0.1 mg/liter (sparfloxacin [SPX]) and 0.5 mg/liter (moxifloxacin [MXF], ciprofloxacin [CIP], and ofloxacin [OFX]). The unbound fraction in the presence of murine serum was concentration dependent for MXF, OFX, SPX, and CIP. In vitro time-kill studies revealed a time-dependent effect, with the CFU reduction on day 7 similar for all four drugs. However, with a J774A.1 murine macrophage tuberculosis infection model, CIP was ineffective at up to 32x MIC. In addition, MXF, OFX, and SPX exhibited less activity than had been seen in the in vitro time-kill study. After demonstrating that the area under the concentration-time curve (AUC) and maximum concentration of drug in plasma were proportional to the dose in vivo, dose fractionation studies with total oral doses of 37.5 to 19,200 mg/kg of body weight (MXF), 225 to 115,200 mg/kg (OFX), 30 to 50,000 mg/kg (SPX), and 38 to 100,000 mg/kg (CIP) were performed with a murine aerosol infection model. MXF was the most efficacious agent (3.0+/-0.2 log10 CFU/lung reduction), followed by SPX (1.4+/-0.1) and OFX (1.5+/-0.1). CIP showed no effect. The ratio of the AUC to the MIC was the pharmacodynamic parameter that best described the in vivo efficacy. In summary, a lack of intracellular killing predicted the lack of in vivo activity of CIP. The in vivo rank order for maximal efficacy of the three active fluoroquinolones was not clearly predicted by the in vitro assays, however.
The structure of the notation system in adults’ number line estimation: An eye-tracking study (2022)

Research on rational numbers suggests that adults experience more difficulties in understanding the numerical magnitude of rational than natural numbers. Within rational numbers, the numerical magnitude of fractions has been found to be more difficult to understand than that of decimals. Using a number line estimation (NLE) task, the current study investigated two sources of difficulty in adults' numerical magnitude understanding: number type (natural vs rational) and structure of the notation system (place-value-based vs non-place-value-based). This within-subjects design led to four conditions: natural numbers (natural/place-value-based), decimals (rational/place-value-based), fractions (rational/non-place-value-based), and separated fractions (natural/non-place-value-based). In addition to percentage absolute error (PAE) and response times, we collected eye-tracking data. Results showed that participants estimated natural and place-value-based notations more accurately than rational and non-place-value-based notations, respectively. Participants were also slower to respond to fractions compared with the three other notations. Consistent with the response time data, eye-tracking data showed that participants spent more time encoding fractions and re-visited them more often than the other notations. Moreover, in general, participants spent more time positioning non-place-value-based than place-value-based notations on the number line. Overall, the present study contends that when both sources of difficulty are present in a notation (i.e., both rational and non-place-value-based), adults understand its numerical magnitude less well than when there is only one source of difficulty present (i.e., either rational or non-place-value-based). When no sources of difficulty are present in a notation (i.e., both natural and place-value-based), adults have the strongest understanding of its numerical magnitude.
Experimental study on the use of a vortex whistle as a flowmeter (2000)

A vortex whistle has a simple structure, good linearity in the relationship between flow and sound frequency, and a wide range in that frequency. This paper suggests that the vortex whistle can be used as a frequency-detecting flowmeter. First, we investigated characteristics of the vortex whistle. We describe a pressure loss model that was built from experimental results. Visualization experiments carried out by using a very high speed camera showed that vortices coming from the outlet of the whistle included flow components whose flow line changed in synchronization with the frequency of the vortex whistle sound. From these results, we confirmed the existence of precession motion of flow around the outlet area. Further, from numerical analysis of the inside of the vortex whistle, we discovered that the sound signal with the best signal-to-noise ratio (SNR) was detected when the microphone was set parallel to the wall of this outlet of the whistle. Furthermore, we researched the temperature characteristic of the vortex whistle sound.
Modeling and process implementation of implanted RESURF type devices (1982)

The relationship between breakdown voltage (B.V.) and drift layer charge (Q <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">D</inf> ) for RESURF type lateral PN diodes was investigated both theoretically using a 2D computer program and experimentally. As an added variable, substrate doping variations were modeled to verify their effect on the diode B.V. rating. The importance of tight charge control in the drift layer region was demonstrated (both theoretically and experimentally). It is concluded that implantation is necessary to yield a tight B.V. distribution. Also shown experimentally is the associated degradation in B.V. that results when the N+ and/or P+ regions have reduced radii of curvature.
Dynamic Testing of a Non-Proprietary, High-Tension, Cable End Terminal System (2014)

Two bogie tests were conducted on a high-tension cable end terminal to evaluate the performance of a new design. The main goals of the new design were to promote quick cable release times, to retain the cable release lever during impact, to sustain no permanent deformation, to have a stub height less than 4 in. (102 mm), and to provide more clearance around the cable anchorage fittings. In test no. HTCT-2, a 1,961-lb (844-kg) bogie vehicle impacted the cable end terminal at a speed of 52.8 mph (85.0 km/h) and an angle of 0 degrees, which is end-on to the terminal. The cable release lever was retained with the rotational joint, and three of the four cables released by 18 ms. However, the second cable did not release from the cable anchor bracket as desired. Minor permanent deformation was found in the cable release lever. In test no. HTCT-3, a 1,853-lb (841-kg) bogie vehicle impacted the cable end terminal at a speed of 51.1 mph (82.2 km/h) and an angle of 25 degrees. All cables released from the cable anchor bracket and the cable release lever was retained. However, the cable release times were later than desired and likely contributed to the bogie vehicle becoming airborne and subsequently rolling. Significant permanent deformation was found in the cable release lever.