gebhart/patrepeval huggingface dataset:
Abstract 1244: Licofelone, a dual COX-LOX inhibitor prevents transitional cell carcinoma of urinary bladder in UPII-SV40T transgenic mice (2014)

Abstract Urinary bladder cancer is the sixth most commonly diagnosed cancer and significant proportion of the patients diagnosed with bladder cancer have high-grade tumors that are at potential risk for post-surgical recurrence and metastasis, where 5-year survival is very low. Hence it is important to identify and develop regimens that prevent urothelial tumorigenesis. Inflammatory pathways particularly, cyclooxygenase (COX-2) and lipoxygenase (5-LOX) mediated metabolites are known to play important role in bladder tumor progression. Consistent with that epidemiological and clinical observations suggest that use of anti-inflammatory agents is associated with reduced risk for bladder cancer. Here we determined the chemopreventive efficacy of a Licofelone, a dual COX-LOX inhibitor, in a transgenic UPII-SV40T mouse model of bladder transitional cell carcinoma (TCC). Six-week old transgenic UPII-SV40T mice (n=30/group) were fed control (AIN-76A) or experimental diets containing 150 or 300 ppm licofelone for 34 weeks. At 40 weeks of age, all mice were euthanized; urinary bladders were collected to determine urothelial tumor weights and histopathological grading. Results suggest that bladders of the control diet fed transgenic mice weighed 3-5 fold more than that of the wild type mice. However, treatment of transgenic mice with licofelone led to a significant, dose dependent inhibition of the urothelial tumor weights (65.2 - 82.7%, p&amp;lt;0.0001 in males; 35.0 - 49.0%, p&amp;lt;0.0001 in females) compared to the control group. Importantly, mice fed licofelone diet significantly reduced development of invasive tumors. Urothelial tumor progression to invasive TCC was inhibited in both male (up to 50%; p&amp;lt;0.01) and females mice (up to 46%; p&amp;lt;0.003). Molecular analysis of urothelial tumors by immuno-histochemisty, qPCR and/or western immunoblotting for the expression of various markers that effect tumor growth and progression showed an increase in apoptosis (p53, p21, Bax, Caspase3, Annexin V) with a decrease in proliferation and angiogenesis (PCNA, COX2, 5LOX, mPGES2, VEGF) in the licofelone diet fed mice tumors. These results suggest that licofelone can serve as potential chemopreventive for bladder TCC. (Supported in part by NCI-CN53300) Citation Format: Venkateshwar Madka, Altaf Mohammed, Qian Li, Yuting Zhang, Laura Biddick, Stanley Lightfoot, Xue-Re Wu, Levy Kopelovich, Vernon Steele, Chinthallapally V. Rao. Licofelone, a dual COX-LOX inhibitor prevents transitional cell carcinoma of urinary bladder in UPII-SV40T transgenic mice. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1244. doi:10.1158/1538-7445.AM2014-1244
The process of consensus on EMF: SAB review of the EPA draft document on EMF and cancer (1992)

The EPA Draft Document on EMF and Cancers grew out of an earlier effort by EPA to track biological effects literature relative to radio-frequency (RF) exposure. Scope of the document was broadened to include extremely low frequency electric and magnetic fields prior to an announcement in 1986 that EPA would formally review the whole area of non-ionizing radiation. An extensive survey of the relevant bioeffects and epidemiologic literature was carried out, and writing on the document began in earnest on the document sometime in 1989. In its draft form, the document reviewed the literature on mechanisms of Interaction between electromagnetic fields and biological tissue, EMF epidemiologic studies, supporting evidence for carcinogenicity and research needs. In the early summer of 1990, a draft of the document was reviewed by some 22 individuals within the EPA and other government agencies. It was also sent out for external review to an additional 9 qualified scientists who had worked in the area and were familiar with EMF-related literature in epidemiology, biology, and physics. Many of the comments sent to EPA from this first review, prior to release of the draft for public comment, were strikingly similar to those resulting from the second (public) review process. Thus, it appears that much of the controversy that was later associated with the document could have been avoided had the authors been diligent in following the recommendations of the initial set of reviewers.
Insulin Resistance and Hypertension (2005)

Information about reprints can be found online at: Reprints: document. Permissions and Rights Question and Answer this process is available in the click Request Permissions in the middle column of the Web page under Services. Further information about Office. Once the online version of the published article for which permission is being requested is located, can be obtained via RightsLink, a service of the Copyright Clearance Center, not the EditorialCirculationin Requests for permissions to reproduce figures, tables, or portions of articles originally publishedPermissions: by guest on March 6,
The Network Access Identifier (2005)

In order to provide roaming services, it is necessary to have a standardized method for identifying users. This document defines the syntax for the Network Access Identifier (NAI), the user identity submitted by the client during network authentication. "Roaming" may be loosely defined as the ability to use any one of multiple Internet Service Providers (ISPs), while maintaining a formal, customer-vendor relationship with only one. Examples of where roaming capabilities might be required include ISP "confederations" and ISP-provided corporate network access support. This document is a revised version of RFC 2486, which originally defined NAIs. Enhancements include international character set and privacy support, as well as a number of corrections to the original RFC.
Organophotoredox-Catalyzed Direct C–H Amination of 2H-Indazoles with Amines (2020)

A general and practical method for the direct C-H amination of 2<i>H</i>-indazoles with a series of amines including aliphatic primary amines, secondary amines, azoles, and sulfoximines via organophotoredox-catalyzed oxidative coupling has been disclosed at room temperature under ambient air conditions. Additionally, this protocol is used for free aminated 2<i>H</i>-indazole synthesis. A mechanistic study revealed that a single electron transfer (SET) pathway might be involved in this reaction.
Stress-Strain Characteristics of Various Steels over a Wide Range of Strain-Rates and Temperatures (1973)

Compression tests are described to determine the flow stresses of steel of specifications: En 1A, En 8, En 26, En 30B, En 58 and 6:5:2 and 18:4:1 high-speed steels, which are presented for use in the analysis of metal working operations. Testing temperatures of 600°C, 800°C, 1000°C and 1200°C were employed and using each of two high-speed hammers and a mechanical press, strain-rates ranging from approximately 12/s to 2500/s were obtained.
A NOVEL DRIFT REMOVAL METHOD FOR GAIT ANALYSIS USING WEARBLE SENSORS (2015)

A major challenge for using wearable sensor systems for motion analysis is sensor drift. It is possible to integrate angular velocity or double integrate acceleration to calculate the orientation of body segments to which the sensors are attached to. However, small signal noise accumulation will cause the integrated values to deviate from the true value, an effect known as drift [1]. The objective of this work is to propose a novel method to reduce the effect of drift from gyro sensors to accurately measure human gait from wearable sensor systems.
Using iterative LQR to control two quadrotors transporting a cable-suspended load (2017)

This paper is focused on the tracking control problem of two quadrotors carrying one cable-suspended payload. The paper main contributions include a dynamic model constructed by Euler-Lagrange equations for this system, an iterative linear quadratic regulator (iLQR) optimal controller, which is able to track the desired trajectory for the payload position and attitude and a simulation for tracking a spiral trajectory. The nonlinear dynamic model is linearised by considering the angles of connected links from the payload to each quadrotor as the equilibrium point. The iLQR control algorithm is developed for the full system consisting of two quadrotors connected with a point mass load in order to improve the tracking performance and avoid the slung load swing. The simulation results demonstrate that the iLQR approach is able to improve the tracking performance compared with an LQR controller.
Cloning of an Unusual Natriuretic Peptide from the South American Coral Snake Micrurus corallinus (1997)

In the course of cloning abundant cDNAs from the South American coral snake Micrurus corallinus venom gland, we characterized a cDNA coding for a putative natriuretic peptide. All the natural natriuretic peptides described so far, possess a ring structure composed of 17 amino acids formed through an S-S bridge which is extended at the N-terminus by few to several amino acids and may be extended at the C-terminus, usually 4-7 amino acids. In contrast, the M. corallinus natriuretic peptide presents several distinct features: (a) the proform of the deduced natriuretic peptide displays an unusual C-terminus extension. This implies that the mature peptide has a long C-terminal tail or it is further extensively processed to result in the mature natriuretic peptide with the expected 4-7 amino-acid extension. (b) the deduced natriuretic peptide presents an unusual internal Cys within the ring structure. This raises the possibility of natriuretic peptides with a smaller ring structure. (c) the putative natriuretic peptide is flanked by two homologous peptides of unknown function. In addition, an analogous peptide was synthesized and assayed on perfused rat kidney, showing a dose-dependent response in urinary volume and sodium excretion. Moreover, northern-blot studies showed that M. corallinus natriuretic peptide transcripts were highly expressed in venom glands, but they were not detectable in other tissues like heart and brain, suggesting a main role for this M. corallinus natriuretic peptide in the venom gland or in the envenomation by this coral snake's bite.
Intracranial complications of acute otitis media and Gradenigo's syndrome. (2013)

We describe the case of a 12-year-old girl with acute otitis media complicated by acute mastoiditis, epidural empyema, thrombosis of the sigmoid sinus and paralysis of the abducens nerve. The patient underwent a mastoidectomy on the left side combined with drainage of the epidural empyema through an extended burr holl and received intravenous antibiotics for 6 weeks and anticoagulation for 12 weeks. This report discusses the intracranial complications of acute otitis media, which were a common problem before the advent of adequate antibiotic drugs but have become rare since their introduction.
How Smart is the Grid? (2021)

Ancient Romans called urbs the set of buildings and infrastructures, and civitas the Roman citizens . Today instead, while the society is surfing the digital tsunami, urbs and civitas tend to become much closer, almost merging, that we might attempt to condensate these into a single concept: smart grid . Internet of things, artificial intelligence, blockchain, and quantum cryptography are only a few of the technologies that are likely to contribute to determining the final portrait of the future smart grid. However, to understand the effective sustainability of complex grids, specific tools are required. To this end, in this article, a new taxonomic framework has been developed starting from a general analysis of the emerging solutions, identifying intersectoral synergies and limitations with respect to the ‘smart grid’ concept. Finally, from the scenario portrayed, a set of issues involving engineering, regulation, security, and social frameworks have been derived in a theoretical fashion. The findings are likely to suggest the urgent need for multidisciplinary cooperation to address engineering and ontological challenges gravitating around the smart grid concept.
CW highly efficient 1.24-μm Raman laser based on low-loss phosphosilicate fiber (2000)

Extremely simple and efficient 1.24 micrometers phosphosilicate fiber-based Raman laser was developed. The cavity of the Raman laser was formed by the Bragg gratings written directly in the phosphosilicate fiber. The investigation of the laser parameters, mathematical simulations and optimization of the Raman laser were carried out. As a result of optimization the 1.24 micrometers output power of 2.4 W was reached at the neodymium fiber laser pump power of 3.6 W, that corresponds to the Raman laser quantum efficiency of 77%.
High-Quality Sodium Rare-Earth Fluoride Nanocrystals:  Controlled Synthesis and Optical Properties (2006)

We report a general synthesis of high-quality cubic (alpha-phase) and hexagonal (beta-phase) NaREF4 (RE: Pr to Lu, Y) nanocrystals (nanopolyhedra, nanorods, nanoplates, and nanospheres) and NaYF(4):Yb,Er/Tm nanocrystals (nanopolyhedra and nanoplates) via the co-thermolysis of Na(CF3COO) and RE(CF3COO)3 in oleic acid/oleylamine/1-octadecene. By tuning the ratio of Na/RE, solvent composition, reaction temperature and time, we can manipulate phase, shape, and size of the nanocrystals. On the basis of its alpha --> beta phase transition behavior, along the rare-earth series, NaREF4 can be divided into three groups (I: Pr and Nd; II: Sm to Tb; III: Dy to Lu, Y). The whole controlled-synthesis mechanism can be explained from the point of view of free energy. Photoluminescent measurements indicate that the value of I610/I590 and the overall emission intensity of the NaEuF4 nanocrystals are highly correlative with the symmetries of the Eu3+ ions in both the lattice and the surface.
Modeling leucine's metabolic pathway and knockout prediction improving the production of surfactin, a biosurfactant from Bacillus subtilis (2015)

A Bacillus subtilis mutant strain overexpressing surfactin biosynthetic genes was previously constructed. In order to further increase the production of this biosurfactant, our hypothesis is that the surfactin precursors, especially leucine, must be overproduced. We present a three step approach for leucine overproduction directed by methods from computational biology. Firstly, we develop a new algorithm for gene knockout prediction based on abstract interpretation, which applies to a recent modeling language for reaction networks with partial kinetic information. Secondly, we model the leucine metabolic pathway as a reaction network in this language, and apply the knockout prediction algorithm with the target of leucine overproduction. Out of the 21 reactions corresponding to potential gene knockouts, the prediction algorithm selects 12 reactions. Six knockouts were introduced in B. subtilis 168 derivatives strains to verify their effects on surfactin production. For all generated mutants, the specific surfactin production is increased from 1.6- to 20.9-fold during the exponential growth phase, depending on the medium composition. These results show the effectiveness of the knockout prediction approach based on formal models for metabolic reaction networks with partial kinetic information, and confirms our hypothesis that precursors supply is one of the main parameters to optimize surfactin overproduction.
Application of HAADF STEM image analysis to structure determination in rotationally disordered and amorphous multilayered films (2016)

We report results from high angle annular dark field scanning transmission electron microscopy (HAADF STEM) image analysis of complex semi-crystalline and amorphous materials, and apply the insights gained from local structure information towards global structure determination. Variations in HAADF STEM intensities for a rotationally disordered heterostructure and an amorphous oxide film are statistically analyzed to extract information regarding the inhomogeneity of the films perpendicular to the substrate. By assuming chemical homogeneity in the film axis parallel to the substrate, the signal intensity variation parallel to the substrate is used to estimate the signal noise level, allowing evaluation of the significance of intensity differences in the substrate normal direction. The positions of HAADF STEM intensity peaks in the perpendicular direction, averaged from multiple images, provide a valuable initial model for a Rietveld refinement of the global c-axis structure of the heterostructure. For an amorphous multi-coat solution-cast oxide sample, the analysis reveals statistically significant variations in the HAADF STEM intensity profile perpendicular to the substrate. These variations indicate an inhomogeneous density profile, presumably related to the spin-casting of individual layers and have implications for understanding the chemical interactions that occur between layers when preparing multilayer amorphous oxide films from solution.
Fimbrin is a homologue of the cytoplasmic phosphoprotein plastin and has domains homologous with calmodulin and actin gelation proteins. (1990)

Fimbrin is an actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. The complete protein sequence (630 residues) of chicken intestine fimbrin has been determined from two full-length cDNA clones. The sequence encodes a small amino-terminal domain (115 residues) that is homologous with two calcium-binding sites of calmodulin and a large carboxy-terminal domain (500 residues) consisting of a fourfold-repeated 125-residue sequence. This repeat is homologous with the actin-binding domain of alpha-actinin and the amino-terminal domains of dystrophin, actin-gelation protein, and beta-spectrin. The presence of this duplicated domain in fimbrin links actin bundling proteins and gelation proteins into a common family of actin cross-linking proteins. Fimbrin is also homologous in sequence with human L-plastin and T-plastin. L-plastin is found in only normal or transformed leukocytes where it becomes phosphorylated in response to IL 1 or phorbol myristate acetate. T-plastin is found in cells of solid tissues where it does not become phosphorylated. Neoplastic cells derived from solid tissues express both isoforms. The differences in expression, sequence, and phosphorylation suggest possible functional differences between fimbrin isoforms.
Endometriosis: An Enigmatic Disease (1996)

For nearly a century, endometriosis has remained a fascinating yet controversial disease. Clinical opinion and formal research have influenced our understanding of this ubiquitous medical enigma. Since the 1970s, there has been an appreciable rise in the diagnosis of endometriosis attributable to the availability of laparoscopy. Although no one disagrees that symptomatic endometriosis should be treated, the choice of treatment, whether surgical or medical, remains controversial.
Robust Image Restoration Matched With Adaptive Aperture Formation In Radar Imaging Systems With Sparse Antenna Arrays (1998)

Publication in the conference proceedings of EUSIPCO, Rhodes, Greece, 1998
Effectiveness of Oral Contraceptive Pills in a Large U.S. Cohort Comparing Progestogen and Regimen (2010)

II
<title>Optical image sensing through turbid water</title> (2005)

Optical image sensing through turbid seawater is one of the most challenging problems in underwater vision for underwater robotic vehicles (URVs). In this article, we intend to briefly review the basic of underwater optical imaging for a start. For more advanced systems, there are two major techniques: time discrimination (lidar imaging, or range-gated) and spatial discrimination (scanning method). Here, we present our underwater lidar imaging (UWLI) experimental system which give very clear revelation of "sliced-view" phenomenon in a 3m tank with very turbid water (1.0/m). And then, we suggest an underwater Lidar PanCam system, which is the combination of the two major techniques above and based on photo-mosaicing approach.
PmST2: A novel Pasteurella multocida glycolipid α2-3-sialyltransferase (2011)

Pasteurella multocida (Pm) is a multi-species pathogen that causes diseases in animals and humans. Sialyltransferase activity has been detected in multiple Pm strains and sialylation has been shown to be important for the pathogenesis of Pm. Three putative sialyltransferase genes have been identified in Pm genomic strain Pm70. We have reported previously that a Pm0188 gene homolog in Pm strain P-1059 (ATCC 15742) encodes a multifunctional sialyltransferase (PmST1). We demonstrate here that while PmST1 prefers to use oligosaccharides as acceptors, PmST2 encoded by the Pm0508 gene homolog in the same Pm strain is a novel glycolipid α2-3-sialyltransferase that prefers to use lactosyl lipids as acceptor substrates. PmST2 and PmST1 thus complement each other for an efficient synthesis of α2-3-linked sialosides with or without lipid portion. In addition, β1-4-linked galactosyl lipids are better PmST2 substrates than β1-3-linked galactosyl lipids. PmST2 has been used successfully in the preparative scale synthesis of sialyllactosyl sphingosine (lyso-GM3), which is an important glycolipid and an intermediate for synthesizing more complex glycolipids such as gangliosides.
Sliding-mode control analog integrated circuit for switching DC-DC power converters (2002)

This communication describes the design and implementation of a microelectronic CMOS analog integrated circuit that provides versatile sliding-mode control laws for switching DC-DC power converters. In addition to perform general linear-surface state control laws, the controller circuit includes compensating dynamics. The proposal of this analog IC design, which operates in current-mode processing, exhibits good performance as far as operation speed, power consumption, suitability for low-voltage operation and robustness in front of interference are concerned. The main circuit, which allows modular connection, is composed of externally linearized transconductors based on current conveyors, current-mode amplifiers and filtering stages, and a transimpedance high-speed hysteretic comparator. Full-transistor-level post-layout simulations for a CMOS 0.8 /spl mu/m technology and experimental results validate the high-speed functionality of the proposed sliding-mode controller ASIC implementation.
ChemInform Abstract: SYNTHESIS OF EXTENDED CHAIN HEPTOSES AND OCTOSES BY NUCLEOPHILIC C‐ACYLATION (1977)

Abstract Bei Reaktion der Dialdose (I) mit den entsprechenden Dithian‐ Carbanionen entstehen die Diastereomeren (II) und (III) in Produktverhältnissen, die von den verwendeten Lösungsmitteln abhängen.