gebhart/patrepeval huggingface dataset:
Characterization of an abundant, unique 1.7-kilobase bovine herpesvirus 4 (BHV-4) late RNA and mapping of a BHV-4 IE2 transactivator-binding site in its promoter-regulatory region (1997)

We characterized an abundant late 1.7-kb cytoplasmic polyadenylated RNA (L1.7 RNA) transcribed from the bovine herpesvirus 4 (BHV-4) HindIII W fragment, in a region of the genome not conserved with Epstein-Barr virus and herpesvirus saimiri. L1.7 RNA contains only extremely short (<100 nucleotides) open reading frames followed by two repeat arrays. The first repeat array contains 11 copies of a 23-bp unit, TGGCACTA GTAGCATTTAACCCC. The second and third copies are each interrupted by 15- to 17-bp sequences that are identical to each other for the first 15 bp. In addition, the second and third copies of the repeat unit each contain two copies of nucleotides 5 to 9 (ACTAG) of the repeat unit, one at each end of the interruption. The second repeat array contains 12 copies of a 25-bp sequence, GCTGTGTATTATTGAGTATTTTTTA. The promoter-regulatory region of L1.7 was activated by the BHV-4 immediate-early gene 2 product (IE2), a homolog of the Epstein-Barr virus R transactivator, in cotransfection assays. We mapped an IE2 recognition site within a 167-bp fragment approximately 10 bp 5' to the start of L1.7 RNA transcription, using cotransfection assays and gel retardation assays. Using gel retardation assays, we mapped an IE2-binding site within this fragment to a 31-bp region from 56 to 86 bp 5' to the start of L1.7 RNA transcription. This IE2-binding site was able to transfer IE2 responsiveness to a heterologous promoter. However, IE2 responsiveness was affected by both position and orientation. Alignment of the L1.7 IE2-binding site sequence with sequences of two other BHV-4 IE2-binding sites resulted in a provisional IE2-binding site consensus sequence different from the Epstein-Barr virus R transactivator-binding site.
Air-Stable Ambipolar Field-Effect Transistors and Complementary Logic Circuits from Solution-Processed n/p Polymer Heterojunctions (2010)

We demonstrate the use of n/p polymer/polymer heterojunctions deposited by sequential solution processing to fabricate ambipolar field-effect transistors and complementary logic circuits. Electron and hole mobilities in the transistors were ∼0.001-0.01 cm(2)/(V s) in air without encapsulation. Complementary circuits integrating multiple ambipolar transistors into NOT, NAND, and NOR gates were fabricated and shown to exhibit sharp signal switching with a high voltage gain.
An Efficient Algorithm for Soft-Decision Decoding of the (24, 12) Extended Golay Code (1981)

An efficient algorithm for soft-decision decoding of the (24, 12) extended Golay code is described. Results obtained for white Gaussian noise are presented which show that performance is only a few tenths of a decibel away from that of an ideal correlator.
Polarization Controlled Fiber Optic Recirculating Delay Line Filter and its Associated Phase Induced Intensity Noise (1988)

By inserting a linear polarizer after a fiber optic recirculating delay line, the system becomes highly polarization dependent. The transfer function and the phase induced intensity noise for different polarization inputs are studied.
Glyphosate Inhibits PPAR Gamma Induction and Differentiation of Preadipocytes and is able to Induce Oxidative Stress (2016)

Glyphosate-based herbicides (GF) are extensively used for weed control. Thus, it is important to investigate their putative toxic effects. We have reported that GF at subagriculture concentrations inhibits proliferation and differentiation to adipocytes of 3T3-L1 fibroblasts. In this investigation, we evaluated the effect of GF on genes upregulated during adipogenesis. GF was able to inhibit the induction of PPAR gamma, the master gene in adipogenesis but not C/EBP beta, which precedes PPAR gamma activation. GF also inhibited differentiation and proliferation of another model of preadipocyte: mouse embryonic fibroblasts. In exponentially growing 3T3-L1 cells, GF increased lipid peroxidation and the activity of the antioxidant enzyme, superoxide dismutase. We also found that proliferation was inhibited with lower concentrations of GF when time of exposure was extended. Thus, GF was able to inhibit proliferation and differentiation of preadipocytes and to induce oxidative stress, which is indicative of its ability to alter cellular physiology.
From microfluidic applications to nanofluidic phenomena (2010)

A graphical abstract is available for this content
The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. (1999)

Loss of p16 functional activity leading to disruption of the p16/cyclin-dependent kinase (CDK) 4:cyclin D/retinoblastoma pathway is the most common event in human tumorigenesis, suggesting that compounds with CDK4 kinase inhibitory activity may be useful to regulate cancer cell growth. To identify such inhibitors, the 60 cancer cell lines of the National Cancer Institute drug screen panel were examined for p16 alterations (biallelic deletion, intragenic mutations, or absent p16 protein), and the growth-inhibitory activity of more than 50,000 compounds against these 60 cell lines was compared with their p16 status. One compound, 3-amino thioacridone (3-ATA; NSC 680434), whose growth-inhibitory activity correlated with the p16 status of the cell lines had an IC50 of 3.1 microM in a CDK4 kinase assay. In addition, four compounds structurally related to 3-ATA inhibited CDK4 kinase with IC50s ranging from 0.2-2.0 microM. All five of these compounds were less potent inhibitors of cell division cycle 2 and CDK2 kinases, with IC50s 30- to 500-fold higher than that for CDK4. ATP competition experiments demonstrated a noncompetitive mode of inhibition for 3-ATA (K(i) = 5.5 microM) and a linear mixed mode for benzothiadiazine (NSC 645787; K(i) = 0.73 microM). We have successfully demonstrated a novel approach to identify specific CDK4 kinase inhibitors that may selectively induce growth inhibition of p16-altered tumors.
System issues in digital image and video watermarking for copy protection (2003)

Watermarking is an emerging technology that is claimed to have an important application in copyright protection. We argue that in many cases still-image watermarks cannot live up to this expectation. We show that the situation is different for video, mainly due to the sheer volume of the data. An overview is given of an important application for video watermarking, viz. DVD copy protection. Finally, we make the case that a total system solution needs more ingredients than watermarking alone.
Thrombin Receptor Polymorphism in Chinese Hamster (1995)

We report the existence of a new Chinese hamster thrombin receptor allele, characterized by an in-frame insertion of three nucleotides at position 250 of the published sequence. As a consequence, an additional proline is inserted into a proline-rich region of the extracellular amino-terminal domain of the receptor. A corresponding proline at this position is also found in the rat thrombin receptor. A silent base-pair change is found in the cytoplasmic tail of the receptor gene. Single-strand conformation polymorphism and sequence analysis indicate this new receptor allele is present in several cell lines derived from different individual Chinese hamsters. Embryonic CHEF IIC9 cells and primary culture cells are homozygous for this new allele. In contrast, the CCL39 lung fibroblast cell line is heterozygous for both the new and old alleles. Both alleles are transcribed into mRNA and code for functional receptors. Given the allelic distribution and sequence alignment with thrombin receptors from other species, we propose that the new sequence represents the actual predominant allele in Chinese hamster.
Frequency comb seeding of a single-mode near-infrared semiconductor laser (2021)

An amplitude-modulated optical frequency comb generated by a passively mode-locked InGaAs double quantum well semiconductor laser is optically injected into a laser emitting a single optical mode continuous wave output in solitary operation. Optical frequency comb generation in the injected laser is experimentally demonstrated and regimes of injection locking are analyzed.
Sperm motility in the horseshoe crab. III. Isolation and characterization of a sperm motility initiating peptide (1982)

Abstract Sperm motility in Limulus is initiated by a sperm motility initiating factor (SMI) that emanates from Limulus eggs. This report describes the partial purification of SMI (greater than 230‐fold purification with respect to protein content) with 40% recovery. SMI appears to be a hydrophobic peptide of 500–2,000 MW. Although probably not purified to homogeneity, SMI is estimated to be active at a concentration of less than 0.2 μM.
A Novel RIS-Assisted Modulation Scheme (2021)

In this work, in order to achieve higher spectrum efficiency, we propose a reconfigurable intelligent surface (RIS)-assisted multi-user communication uplink system. Different from previous work in which the RIS only optimizes the phase of the incident users' signal, we propose the use of the RIS to create a virtual constellation diagram to transmit the data of an additional user. We focus on the two-user case and develop a tight approximation for the probability distribution function (PDF) of the minimum distance between constellation points of both users. Then, based on the proposed statistical distribution, we derive the analytical expressions of the average bit error rate of the considered two users. The letter also shows the trade off between the performance of two users as a function of the proposed phase shift at the RIS.
Novel Passive Implantable Atrial Defibrillator Using Transcutaneous Radiofrequency Energy Transmission Successfully Cardioverts Atrial Fibrillation (2003)

Considering these animal results, this method is promising for cardioverting AF in symptomatic patients.
Android based fluid dispensing and blending system automation (2014)

This paper discusses the development of an android based smart automated fluid dispensing and blending system. The developed system confines to juice dispensing and blending application used in food processing. The system operation is sliced into three layers of operations; user layer, decision making layer, and an action layer. The user layer consists of a touch screen based mobile application which is used for human interaction and input entry. Once the selection is made the data will be transmitted to the controller in the decision making layer over Bluetooth. In decision making layer, the system collects inputs from the user layer and based on the developed software algorithm makes a decision on the fluid flavor, type of water and proportional quantity to be dispensed. Further pass the information to the action layer. The decision making layer is made up of ARM Controller LPC2129, sensors like level and temperature sensor. All the peripheral devices communicate to ARM controller over the CAN bus. The action layer consists of motors, pumps, relays and associated circuitry. The action layer controls the relays and regulates the pumps according to which the juice will be dispensed. Additional features such as machine over temperature, shortage of product, alert mechanism also been incorporated into the system and these messages will be received on the mobile phone for taking necessary action. The developed system has the following typical features: wireless Bluetooth, improved speed in product delivery, future expansion over CAN protocol, safety, and warning systems.
Solution-Processable Star-Shaped Photovoltaic Organic Molecule with Triphenylamine Core and Benzothiadiazole−Thiophene Arms (2009)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTSolution-Processable Star-Shaped Photovoltaic Organic Molecule with Triphenylamine Core and Benzothiadiazole−Thiophene ArmsJing Zhang†‡, Yi Yang†‡, Chang He†, Youjun He†‡, Guangjin Zhao†‡, and Yongfang Li*†View Author Information† Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China‡ Graduate University of Chinese Academy of Sciences, Beijing 100049, China*Corresponding author: E-mail [email protected], Fax 86-10-62559373.Cite this: Macromolecules 2009, 42, 20, 7619–7622Publication Date (Web):September 30, 2009Publication History Received26 August 2009Revised24 September 2009Published online30 September 2009Published inissue 27 October 2009https://pubs.acs.org/doi/10.1021/ma901896nhttps://doi.org/10.1021/ma901896nrapid-communicationACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views2918Altmetric-Citations126LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Absorption,Electrodes,Molecules,Organic compounds,Power conversion efficiency Get e-Alerts
Characterization of Inner Retinal Hyperreflective Alterations in Early Cognitive Impairment on Adaptive Optics Scanning Laser Ophthalmoscopy (2019)

Individuals with early cognitive impairment related to Alzheimer's show hyperreflective granular membranes on high-resolution imaging, which we hypothesize to be manifestations of inner retinal gliosis. The presence of these subtle hyperreflective membranes may obscure underlying RNFL thinning in these eyes on OCT imaging. The distinctive phenotype of granular membranes surrounding the optic nerve on AOSLO may represent a new potential biomarker of early Alzheimer's.
Static elaboration of recursion for concurrent software (2008)

Unlike sequential software, concurrent software needs a structuring mechanism capable of specifying constructs such as pipelines, scatter-gather, and other networks. Concurrent software languages usually provide mechanisms for dynamically creating such structures, but this makes them difficult to analyze statically. In particular, it would be very convenient to be able to put bounds on the resources (memory, processes) required by a particular system.
Single shot laser writing with sub-nanosecond and nanosecond bursts of femtosecond pulses (2017)

A method is proposed for efficient laser modification of fused silica and sapphire by means of a burst of femtosecond pulses having time separation in the range 10-3000 ps. Modification enhancement with the pulse separation increase in the burst was observed on the tens picoseconds scale. It is proposed that accumulated transient tensile strain in the excitation region plays a crucial role in modification by a sub-nanosecond burst.
[Facilitative effect of glycine on regulation of baroreflex in the hypothalamic paraventricular nucleus of conscious rats.]. (2009)

The hypothalamic paraventricular nucleus (PVN) is a central site for integration of the endocrine system and the autonomic nervous system. Despite a number of studies have pointed out the importance of the PVN in the central regulation of cardiovascular functions, the chemical mediators in the PVN responsible for mediating baroreflex are not well understood. In the present study, we used the conscious rats to investigate the possible involvement of glycine (Gly) in PVN in the central regulation of baroreflex induced by intravenous injection of phenylephrine (0.8 mug/0.04 mL, in 3 min). Then, the microdialysis sampling was performed in the PVN and the concentration of Gly in the microdialysate was measured by high performance liquid chromatography (HPLC) combined with electrochemical techniques, and mean arterial pressure (MAP) and heart rate (HR) were recorded simultaneously. Injection of phenylephrine elicited a significant increase (P<0.01) in MAP from the baseline of (99.5+/-14.2) mmHg to the maximum of (149.8+/-19.5) mmHg and a decrease (P<0.01) in HR from the baseline of (400.8+/-33.1) beats/min to the minimum of (273.4+/-40.8) beats/min, respectively. Synchronously, the injection of phenylephrine increased the level of Gly in the microdialysate from the PVN to (162.9+/-27.3)% of the basal level (P<0.05). Perfusion of strychnine (100 mumol/L), an antagonist of Gly receptor, into the PVN enhanced the pressor response and attenuated the bradycardic response during the baroreflex, resulting in a decrease in baroreflex sensitivity (P<0.001). Whereas, the perfusion of Gly (1 mmol/L) into the PVN did not affect the pressor response but enhanced the bradycardic response during the baroreflex, resulting in an increase in baroreflex sensitivity (P<0.001). These results suggest that endogenous Gly in the PVN may act via strychnine-sensitive Gly receptor to produce a facilitative effect on baroreflex.
Catalytic wall reactors: VOx/TiO2/stainless steel catalyst and its catalytic properties in the oxidative dehydrogenation of propane (2005)

Poster
A Ratiometric Fluorescence Probe for Selective Visual Sensing of Zn2+ (2005)

A simple ratiometric fluorescence probe based on vinylpyrrole end-capped bipyridine for the visual sensing of Zn2+ under aqueous physiological pH (6.8-7.4) is described. The fluorophores 3a-c showed strong emission around 537 nm in acetonitrile with a quantum yield of 0.4. In buffered (HEPES, pH 7.2) acetonitrile-water mixture (9:1 v/v), titration of transition metal salts to 3c showed strong quenching of the emission at 547 nm except in the case of Zn2+, which resulted in a red-shifted emission at 637 nm. Alkali and alkaline earth metal salts could not induce any considerable changes to the emission behavior of 3a-c. The binding of Zn2+ was highly selective in the presence of a variety of other metal ions. Though Cu2+ quenches the emission of 3c, in the presence of Zn2+, a red emission prevails, indicating the preference of 3c toward Zn2+. Job plot and Benesi-Hildebrand analysis revealed a 1:1 complexation between the probe and the metal ion. The selective visual sensing of Zn2+ with a red emission is ideally suited for the imaging of biological specimens.
16 W continuous-wave output power from 100 µm-aperture laser with quantum well asymmetric heterostructure (2004)

16 W continuous-wave room temperature front facet output optical power and 74% wallplug efficiency were attained in 100 µm-aperture 1.06 µm-emitting laser diodes with 2–3 mm cavity length. The lasers are based on AlGaAs/GaAs/InGaAs quantum well asymmetric heterostructures with 1.7 µm-thick waveguide having 0.34 cm−1 internal optical loss.
<title>New results on optimality and consistency of morphological openings and closings</title> (1995)

ABSTRACT It has been recently shown that morphological openings and closings can be viewed as consistent MAP es- timators of morphologically smooth signals in i.i.d. noise. We revisit this viewpoint under a different set of assumptions, which allows the explicit incorporation of geometric and morphological constraints into the noisemodel, i.e., the noise may now exhibit geometric structure; surprisingly, it turns out that this affects neither theoptimality nor the consistency of these filters.Keywords: Opening, Closing, MAP Optimality, Consistency of MAP Estimator 1 INTRODUCTION In two recent papers24'25 Sidiropoulos et al. have obtained statistical proofs of MAP optimality and strongconsistency of morphological openings and closings. These results were made possible by casting the filtering problem within a general framework of Uniformly Bounded Discrete Random Set (or, Discrete Random Set (DRS) , for short) theory.23'2'•A DRS X is simply defined as a measurable mapping from some probability space to a measurable space(E(B), E(E(B))), where E(B) is a complete lattice with a finite least upper bound (usually, the power set of some
A Lot to Ask (reviewing Martha Nussbaum, From Disgust to Humanity: Sexual Orientation and Constitutional Law (2010)) (2010)

From Disgust to Humanity: Sexual Orientation and Constitutional Law encapsulates well the book's normative and descriptive claims.In Nussbaum's descriptive account, the politics of disgust have been and remain at the root of all opposition to recognition of legal rights for homosexuals, whether the issue be sodomy laws, discrimination on the basis of sexual orientation, same-sex marriage or venues for public sex.Although she acknowledges that explicit appeals to disgust have declined in recent years, Nussbaum argues that disgust "has not gone away, it has gone underground."'In Nussbaum's normative view, disgust not only should be ruled categorically out of bounds as a basis for law and policy, but must be thoroughly extirpated and replaced with a "politics of humanity" involving not only sympathy, imagination, and respect, but "something else, something closer to love." 2 From the moment early in its conception when she first sought my input on this new book, I had to confess myself troubled by its central claims, given my own very different take on the constitutional law of sexual orientation.