gebhart/patrepeval huggingface dataset:
Automated launch, recovery, and refueling for small unmanned aerial vehicles (2004)

Small unmanned aerial vehicles (UAVs) are hindered by their limited payload and duration. Consequently, UAVs spend little time in their area of operation, returning frequently to base for refueling. The effective payload and duration of small UAVs is increased by moving the support base closer to the operating area; however this increases risk to personnel. Performing the refueling operations autonomously allows the support base to be located closer to the operating area without increasing risk to personnel. Engineers at SPAWAR Systems Center San Diego (SSC San Diego) are working to develop technologies for automated launch, recovery, refueling, rearming, and re-launching of small UAVs. These technologies are intended to provide forward-refueling capabilities by teaming small UAVs with large unmanned ground vehicles (UGVs). The UGVs have larger payload capacities so they can easily carry fuel for the UAVs in addition to their own fuel and mission payloads. This paper describes a prototype system that launched and recovered a remotely-piloted UAV from a UGV and performed automated refueling of a UAV mockup.
Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma (2022)

Taken together, our findings establish novel pathophysiological roles and functions for LOXL2 in PDAC, which could be potentially exploited to treat metastatic disease.
Organic Dyes Incorporating Bis-hexapropyltruxeneamino Moiety for Efficient Dye-Sensitized Solar Cells (2010)

We report here on the synthesis and photophysical/electrochemical properties of three functional triarylamine organic dyes (MXD5−7) as well as their application in dye-sensitized nanocrystalline TiO2 solar cells (DSSCs). For the designed dyes, the nonplanar structures of bis-hexapropyltruxeneamino take the role of electron donor. The introduction of bis-hexapropyltruxeneamino units brought about superior performance over the simple triphenylamine dye, in terms of light-capturing abilities and suppressing dye aggregation. Among three dyes, the DSSCs based on the dye MXD7 showed the best photovoltaic performance: a short-circuit photocurrent density (JSC) of 11.8 mA cm−2, an open-circuit photovoltage (VOC) of 772 mV, and a fill factor (ff) of 0.68, corresponding to an overall conversion efficiency of 6.18% under 100 mW cm−2 irradiation. These dyes exhibited high VOC values, possible origin for which was investigated regarding the TiO2 surface blocking, conduction band movement, and electrolyte-dye interaction.
[Myoblast transplantation for heart failure: where are we heading?]. (2005)

Cell therapy in cardiology is already a reality, as evidenced by the number of ongoing clinical trials. These studies entail administration of either skeletal myoblasts in patients with severe ischemic left ventricular dysfunction or of bone marrow-derived cells in patients with acute myocardial infarction and in whom cell therapy is an adjunct to a percutaneous revascularization procedure. The techniques of preparation, expansion and storage of myoblasts are now quite effective. The problem is simpler for bone marrow cells as in most studies, the procedure is limited to an iliac crest biopsy followed by reinjection of the crude, unfractionated bone marrow, as routinely done in clinical haematology since many years. The results of these studies are not yet fully available. Some of them have been enthusiastically reported to be positive but should be interpreted cautiously because of the usually small sample sizes and the common lack of randomisation and double-blind assessment of outcomes. Thus, the fact that cell therapy has now become a reality should not lead to underscore the yet unsettled fundamental issue, i.e., the ability of this novel mode of therapy to truly regenerate areas of necrotic myocardium and restore function in once akinetic territories. From this standpoint, cell therapy is still a dream. Since the beginning, it has been clear that myoblasts were exclusively committed to differentiate into myotubes, without any evidence for a phenotypic conversion into cardiomyocytes. Although the debate is more controversial for bone marrow cells, the reliance on accurate genetic methods of cell tracking has led to increasingly challenge the purported plasticity of these cells. This by no means implies that cell therapy does not exert beneficial effects that could be mediated by alternate mechanisms like limitation of remodelling of paracrine effects. The basic point is that neither skeletal myoblasts nor bone marrow cells fulfill the major criteria required for a true cardiac regeneration: a coupling of the grafted cells with those of the recipient myocardium and the subsequent generation of a contractile force. It is therefore critical to go on exploring other paths, among which embryonic stem cells are particularly attractive.
Laparoscopic Antireflux Surgery What is Real Progress? (1994)

Laparoscopy is a good approach for achieving successful antireflux surgery in selected cases. However, its fails to substantially reduce postoperative complication rate and discomfort, duration of the hospital stay, and the risk of esthetic sequela. Early return to work is questionable for manual workers. The subdiaphragmatic Nissen fundoplication is not an all-purpose antireflux procedure.
Photocurrent oscillations in GaInNAs / GaAs multi-quantum well p-i-n structures (2011)

In this work the photoconductivity of a p-i-n Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.952</sub> In <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.048</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.016</sub> As <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.984</sub> /GaAs multiple quantum well (MQW) structure is investigated as a function of temperature. At low temperatures step-like increases are observed in the devices I-V characteristic when illuminated with a 950nm wavelength light. The number of visible oscillations varies according to the temperature and incident light intensity with a maximum of 18 being visible. Since the exciting illumination energy is bellow the GaAs bandgap, these oscillations arise only from the GaInNAs quantum wells and can be explained in terms of resonant tunneling from subbands into the adjacent quantum well.
Peripheral Blood Immunological Parameters for Use as Markers of Pre-invasive to Invasive Colorectal Cancer (2002)

In cancer, the extent to which the disease has spread is probably the most important factor in determining patient prognosis. Hence practical and non-invasive methods are needed to identify disease stage. In a previous paper we showed how diagnostic and prognostic indices for disease progression could be defined by evaluating parameters in peripheral blood. The aim of this study was to identify further serum parameters that could be used. Serum levels of interferon (IFN) gamma, interleukin (IL)4, IL8, IL7, IL1 beta, tumor necrosis factor (TNF) alpha, granulocyte macrophage-colony stimulating factor (GM-CSF), soluble (s) IL2 receptor (R) and sIL6R were studied but only levels of IL4, sIL2R, IL8 and IL7 were found to be significant and would therefore be of use in defining diagnostic and prognostic indices for disease progression. In further detail, our results indicate that when serum levels of sIL2R < 522 U/ml, IL4 < 159 pg/ml and IL8 > 339 pg/ml there is a 95% probability that the disease is in stage I or II where there is no infiltration of lymph nodes; when serum levels of sIL2R > or = 522 Ug/ml, 159 pg/ml < or = IL4 < or = 319 pg/ml, and IL7 < 54 pg/ml, there is a 95% probability that the disease is in stage III and the tumor has invaded the lymph nodes; when the serum levels of IL4 > or = 431 pg/ml and IL7 > or = 54 pg/ml, there is a 95% probability that the disease is in stage IV and there is metastasis.
The Basement Membrane: Key to the Reverse Engineering Biological Tissues (2010)

We reveal the basement membrane, a specialized connective tissue structure found in all tissue systems, as a framework in an adaptive computer aided design (CAD) strategy for the reverse engineering of 3 dimensional (3D) tissue structures. Our approach to the creation of functional 3D tissue structures is centered on our previous models of vascular supply systems which included complete and accurate replications of capillary bed systems, the circulatory interface necessary to sustain 3D tissue structures. By using the basement membrane as a guide, we seek to design models for the reverse engineering of the other extracellular connective tissue structures and their matrix elements. We demonstrate the basement membrane as a platform for the design and engineering of tissue scaffolding for vascularized alveolar systems in the lung and for the vascularized dermal skin layer. The resulting structure will support the 3D growth and differentiation of cells and their products. The biomedical industry stands to be greatly impacted by this CAD approach to the engineering of 3D tissue structures.
Development of calcium stabilized nitrogen rich alpha-sialon ceramics along the Si3N4:1/2Ca3N2:3AlN line using spark plasma sintering (2020)

<title>Abstract</title> Calcium stabilized nitrogen rich sialon ceramics having a general formula of Ca<sub>x</sub>Si<sub>12-2x</sub>Al<sub>2x</sub>N<sub>16</sub> with x value in the range of 0.2-2.2 for compositions lying along the Si<sub>3</sub>N<sub>4</sub>:1/2Ca<sub>3</sub>N<sub>2</sub>:3AlN line were synthesized using nano/submicron size starting powder precursors and spark plasma sintering (SPS) technique. The development of calcium stabilized nitrogen rich sialon ceramics at a significantly low sintering temperature of 1500°C (typically reported a temperature of 1700°C or greater) remains to be the highlight of the present study. The SPS processed sialons were characterized for their microstructure, phase and compositional analysis, physical and mechanical properties. Furthermore, a correlation was developed between the lattice parameters and the content (x) of the alkaline metal cation in the alpha-sialon phase. Well densified single-phase nitrogen rich alpha-sialon ceramics were achieved in the range of 0.53(3) ≤ x ≤ 1.27(3). A nitrogen rich alpha-sialon sample possessing a maximum hardness of 22.4 GPa and fracture toughness of 6.1 MPa.m<sup>1/2</sup> was developed.<bold> </bold>
O Antigen Modulates Insect Vector Acquisition of the Bacterial Plant Pathogen Xylella fastidiosa (2015)

ABSTRACT Hemipteran insect vectors transmit the majority of plant pathogens. Acquisition of pathogenic bacteria by these piercing/sucking insects requires intimate associations between the bacterial cells and insect surfaces. Lipopolysaccharide (LPS) is the predominant macromolecule displayed on the cell surface of Gram-negative bacteria and thus mediates bacterial interactions with the environment and potential hosts. We hypothesized that bacterial cell surface properties mediated by LPS would be important in modulating vector-pathogen interactions required for acquisition of the bacterial plant pathogen Xylella fastidiosa , the causative agent of Pierce's disease of grapevines. Utilizing a mutant that produces truncated O antigen (the terminal portion of the LPS molecule), we present results that link this LPS structural alteration to a significant decrease in the attachment of X. fastidiosa to blue-green sharpshooter foreguts. Scanning electron microscopy confirmed that this defect in initial attachment compromised subsequent biofilm formation within vector foreguts, thus impairing pathogen acquisition. We also establish a relationship between O antigen truncation and significant changes in the physiochemical properties of the cell, which in turn affect the dynamics of X. fastidiosa adhesion to the vector foregut. Lastly, we couple measurements of the physiochemical properties of the cell with hydrodynamic fluid shear rates to produce a Comsol model that predicts primary areas of bacterial colonization within blue-green sharpshooter foreguts, and we present experimental data that support the model. These results demonstrate that, in addition to reported protein adhesin-ligand interactions, O antigen is crucial for vector-pathogen interactions, specifically in the acquisition of this destructive agricultural pathogen.
CuI/DMPAO-Catalyzed N-Arylation of Acyclic Secondary Amines (2012)

DMPAO has been found to be a powerful ligand to enable copper-catalyzed coupling of aryl halides with aliphatic acyclic secondary amines take place under relatively mild conditions, and coupling of aryl halides with primary amines and cyclic secondary amines proceeds at low catalyst loading.
Initiation of antibody responses by different classes of lymphocytes. II. Differences in the tissue distribution of lymphocytes involved in primary and secondary antibody responses. (1970)

Thoracic duct cells and spleen cells from normal and immunized Lewis rats were injected into syngeneic recipients which had received 500 R x-irradiation 2 hr earlier. Tetanus and diphtheria toxoids were injected 24 hr after irradiation and the antibody response was measured for 2 to 3 weeks thereafter. Immunologically competent units were detected in normal spleen cells but not in normal thoracic duct cells. Immunization of the cell donors produced at least a 103- to 104-fold increase in units in the thoracic duct lymph and a much smaller increase in units in the spleen resulting in a change in the distribution (relative concentrations) of units in these lymphoid tissues.
Lumbar Epidural Injections: Fluoroscopy (2016)

Lumbar epidural injection is most often performed for patients experiencing low back pain with radicular symptoms. The radicular symptoms can be precipitated by disc herniation or foraminal stenosis. In addition, spinal stenosis with associated neurogenic claudication is another common indication for this injection. These procedures may be effective in treatment of other syndromes that are associated with radiculopathic low back pain, including intervertebral disc degeneration without disc herniation, central spinal stenosis, spondylothesis, and failed lumbar back surgery syndrome. Lumbar epidural steroid injection (LESI) is the most commonly performed intervention. Fluoroscopically guided lumbar epidural injections led to a lower rate of complications than that reported for all lumbar epidural injections.
Modeling of the Phase Separation Behavior of Polydisperse Semi‐Flexible Diblock Copolymers (2004)

Abstract Summary: A modified random phase approximation method with a cumulant expansion for the semi‐flexible structure factor of diblock copolymers was exercised to describe the phase separation behavior of semi‐flexible and polydisperse diblock copolymers. Scattering curves and spinodal diagrams were calculated applying monomer specific input parameters. The influence of polydispersity was included applying basic concepts of mathematical statistics utilizing several probability density distributions in the case of the two single blocks. In contrast to semi‐flexibility, the main effect of polydispersity was found to shift the spinodal up, thus to enlarge the range of existence of the homogeneous phase. Twofold Schultz‐Zimm distribution of diblock copolymers. magnified image Twofold Schultz‐Zimm distribution of diblock copolymers.
A phase 1/2 study of RTX-224, an engineered red blood cell expressing 4-1BB ligand and membrane-bound IL-12, for the treatment of patients with select advanced solid tumors. (2022)

TPS2680 Background: RTX-224 is a genetically engineered off-the-shelf, allogeneic red blood cell that expresses the costimulatory molecule 4-1BB ligand (4-1BBL) and cytokine interleukin-12 (IL-12) on the cell surface. The use of 4-1BB and IL-12 agonists for cancer immunotherapy has been limited due to systemic toxicities. Unlike agonist antibodies and recombinant cytokines, which are distributed systemically, Red Cell Therapeutics, such as RTX-224, are restricted to the vasculature and spleen, which may limit toxicities previously observed with agonist 4-1BB monoclonal antibodies and recombinant IL-12. RTX-224 is designed to be a broad immune agonist of both adaptive and innate responses that activates and expands effector and memory CD8+ and CD4+ T cells, cytotoxic natural killer (NK) cells and produces inflammatory cytokines and chemokines, leading to enhanced antigen presentation. In preclinical studies, the combined activation of both adaptive and innate immune responses by the murine surrogate of RTX-224 led to antitumor activity while the restricted biodistribution improved the safety profile. Methods: The RTX-224-01 study is a Phase 1/2, first-in-human, multi-center, dose-escalation and expansion study of RTX-224 in patients with relapsed or refractory urothelial cancer, squamous cell carcinoma of the head and neck, non-small cell lung cancer, triple negative breast cancer and cutaneous melanoma. Safety, tolerability, pharmacokinetics and pharmacodynamics and anti-tumor activity of RTX-224 will be assessed. Approximately 28 patients will be enrolled across dose level cohorts to identify the recommended Phase 2 dose (RP2D). The starting dose is 100 million (1x10 8 ) cells administered intravenously every 3 weeks (Q3W) and the dose will be escalated by half-log increments following a Bayesian logarithmic regression model (BLRM) with overdose control. Following RP2D selection, each of the 5 expansion cohorts will enroll approximately 20 patients. Pharmacodynamic and exploratory biomarker studies correlative to clinical response will be evaluated on peripheral blood and paired tumor biopsies. Multiple technologies will be employed to profile the innate and adaptive responses following RTX-224 treatment. The study is open and enrolling patients in Phase 1. Clinical trial information: NCT05219578.
Utilization of the intense pulsed neutron source (IPNS) at Argonne National Laboratory for neutron activation analysis (1983)

The Intense Pulsed Neutron Source (IPNS) neutron scattering facility (NSF) has been investigated for its applicability to neutron activation analysis. A polyethylene insert has been added to the vertical hole VT3 which enhances the thermal neutron flux by a factor of two. The neutron spectral distribution at this position has been measured by the multiple-foil technique which utilized 28 activation reactions and the STAYSL computer code. The validity of this spectral measurement was tested by two irradiations of National Bureau of Standards SRM-1571 (orchard leaves), SRM-1575 (pine needles), and SRM-1645 (river sediment). The average thermal neutron flux for these irradiations normalized to 10 ..mu..amp proton beam is 4.0 x 10/sup 11/ n/cm/sup 2/-s. Concentrations of nine trace elements in each of these SRMs have been determined by gamma-ray spectrometry. Agreement of measured values to certified values is demonstrated to be within experiment error.
Supplemenary Figure 6 from A Phase I Study of the Combination of Rituximab and Ipilimumab in Patients with Relapsed/Refractory B-Cell Lymphoma (2023)

&lt;p&gt;Supplementary Figure 6&lt;/p&gt;
Gamma radiation for in‐stent restenosis: effect of lesion length on angiographic and clinical outcomes (2004)

The relation between lesion length and effectiveness of gamma radiation treatment (gamma-RT) has not been well described. We evaluated the acute and long-term outcome according to baseline lesion length in 130 patients treated with (192)Ir in the Washington Radiation for In-Stent Restenosis Trial; 44 (35.5%) had baseline short in-stent restenosis (ISR) lesions (length < 15 mm) and 80 (64.5%) long ISR lesions (length > or = 15 mm). At 6-month follow-up after gamma-RT, the short ISR group had larger lumen dimensions and lower late loss than the long ISR group. Restenosis rate was significantly higher in patients with long ISR for both the placebo (74% vs. 39%; P = 0.01) and the gamma-RT arm (31% vs. 5.3%; P = 0.04). gamma-RT significantly improved the angiographic outcome in the short-lesion groups but had the more pronounced effect on the reduction of clinical events after treatment of long ISR group. Lesion length remains a powerful predictor of recurrent ISR and clinical events after treatment of ISR even with gamma-RT.
NEONATAL CALF DIARRHEA (1993)

Neonatal calf diarrhea (NCD), also known as calf scours, is a common disease affecting the newborn calf. The most critical period is in the first few days following birth of the calf. Greatest losses occur when calves are kept in close confinement, where the opportunity for transmission of the causative agents of NCD is enhanced by their build-up in the environment. The diarrhea and other clinical signs seen with the disease are caused by the interaction of any of several possible infectious causes and predisposing factors such as lack of colostrum, failure to absorb colostral antibody, poor nutrition and environmental affects. NCD is a costly disease, with losses estimated to be over $250 million annually and death loss of up to 25% of the U.S. calf crop.
Reconfigurable Systems for Cryptography and Multimedia Applications (2012)

The area of reconfigurable computing has received considerable interest in both its forms: fine-grained (represented in FPGA) and coarse-grained architectures. Both architecture styles attempt to combine two of the important traits of General Purpose Processors (GPPs) and Application-Specific Integrated Circuits (ASICs): flexibility and speed (Hartenstein, 2001). It provides performance close to application-specific hardware and yet preserves, to a certain degree, the flexibility of general-purpose processors. In this chapter, we explore, evaluate, and analyze the performance of a reconfigurable hardware, namely MorphoSys, considering certain key applications targeted for such hardware (Hauck, 1998).
Molecular design for nonpolymeric organic dye glasses with thermal stability: relations between thermodynamic parameters and amorphous properties (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular design for nonpolymeric organic dye glasses with thermal stability: relations between thermodynamic parameters and amorphous propertiesKatsuyuki Naito and Akira MiuraCite this: J. Phys. Chem. 1993, 97, 23, 6240–6248Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/j100125a025https://doi.org/10.1021/j100125a025research-articleACS PublicationsRequest reuse permissionsArticle Views1639Altmetric-Citations264LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Corruption and the extractive industries in Africa : can combatting corruption cure the resource curse? (2007)

After reaching a low point in 2002, the extractive industries globally have seen a remarkable turnaround in the past few years.