gebhart/patrepeval huggingface dataset:
Teaching Electromagnetics: Innovative Approaches and Pedagogical Strategies [Book Review] (2022)

This book aims at providing ideas and discussion points on the main contemporary challenges of undergraduate EM education, was perfectly timed. It consists of 13 chapters, partitioned into four main parts. The introductory part in Chapters 1 and 2 presents the book’s general motivation and philosophy; reviews the challenges in designing the EM curriculum, course syllabus, teaching environment, and learning experience; and motivates the development of tools and approaches for interactive and engaging learning. Following the outline in Chapter 1, the book focuses on the two primary axes of Kolb’s four-stage learning cycle: experiential and conceptual learning. The book’s second part (Chapters 3–6) focuses on the exper iential aspect. Chapter 3 explains the learning cycle and demonstrates it through a case study of an advanced course program that includes a progression of design and analysis project tasks, with various industrial outcomes. The examples of students’ projects and their feedback on the process are used to assess the approach’s effectiveness. Although carefully curated with a general philosophy in mind, the book does not advocate for one approach, nor does it impose a rigid teaching paradigm. It is more of a snapshot of contemporary thought on EM education and newly available teaching tools and techniques, suggested by peers, which serves as a substrate for further discussion. Indeed, my urge while the reading to bring up these topics with my colleagues immediately sparked some very passionate and intriguing conversations. Evidently, the book achieves its primary aim: to further the ever-continuing discussion among teachers and students on bettering education in our field.
Compact B-trees (1979)

A B-tree is compact if it is minimal in number of nodes, hence has optimal space utilization, among equally capacious B-trees of the same order. The space utilization of compact B-trees is analyzed and is compared with that of noncompact B-trees and of (node)-visit-optimal B-trees, which minimize the expected number of nodes visited per key access. Compact B-trees can be as much as a factor of 2.5 more space-efficient than visit-optimal B-trees; and the node-visit cost of a compact tree is never more than 1 + the node-visit cost of an optimal tree. Finally, an in-place compactification algorithm is presented which operates in linear time in the size of the file.
T- and Y-splitters based on an Au/SiO2 nanoring chain at an optical communication band (2012)

In this paper, we have utilized Au nanoring chains in an SiO2 host to design certain T-and Y-structures, and expanded it to transport and split the electromagnetic energy in integrated nanophotonic devices operating at an optical communication band (λ≈1550 nm). We compared two structures and tried to choose the best one, with lower losses and higher efficiency at the output branches, in order to split and transport the optical energy. Comparing the different types of nanoparticles corroborates that nanorings have an extra degree of tunability in their geometrical components. Meanwhile, nanorings show strong confinement in near-field coupling, less extinction coefficient, and also lower scattering into the far field during energy transportation at the C-band spectrum. Due to the nanoring's particular properties, transportation losses would be lower than in other nanoparticle-based structures like nanospheres, nanorods, and nanodisks. We demonstrate that Au nanorings surrounded by an SiO2 host yield suitable conditions to excite surface Plasmons inside the metal. Comparison between Y-and T-splitters shows that the Y-splitter is a more suitable alternative than the T-splitter, with higher transmission efficiency and lower losses. In the Y-structure, the power ratio (time-averaged power across the surface) is 24.7%, and electromagnetic energy transportation takes place at group velocities in the vicinity of 30% of the velocity of light; transmission losses are γT=3 dB/655 nm and γT=3 dB/443 nm. In this work, we have applied the finite-difference time-domain method (FDTD) to simulate and indicate the properties of structures.
Factors Associated with Dose Modification of Lenalidomide Plus Dexamethasone Therapy in Multiple Myeloma (2020)

Long-term combination treatment with lenalidomide and low-dose dexamethasone is important to achieve a curative effect in patients with multiple myeloma (MM). In this study, the plasma concentration of lenalidomide was measured at 3 h after oral administration, when the drug is in the elimination phase and can be easily measured in outpatients, to identify factors that may lead to the discontinuation of this combination therapy. Patients were assigned to continuation or discontinuation of therapy groups, and the baseline characteristics of patients, lenalidomide concentration, and concentration/dose (C/D) ratios reflecting oral clearance were compared between the two groups. The efficacy and severity of adverse events were also compared. The results showed that patients who discontinued or modified treatment had low plasma concentrations of lenalidomide and C/D ratios, indicating high oral clearance of lenalidomide. The estimated creatinine clearance rate was negatively correlated with the C/D ratio. The plasma concentrations of lenalidomide were independent from kidney function and differed significantly among patients. Taken together, the results indicate that low plasma concentrations of lenalidomide and low C/D ratios may lead to discontinuation of combination therapy in patients with MM. This suggests that early measurement of lenalidomide plasma continuation would help to prevent discontinuation of therapy or a delay in modifying the dose of lenalidomide.
Monoclonal antibody that recognizes the carbohydrate portion of cell adhesion molecule L1 influences calcium current in cultured neurons (1992)

A monoclonal antibody (mAb), 2E12, against the neural cell adhesion molecule L1 recognized the 200 kDa component of L1. The epitope of L1 reacting with mAb 2E12 was localized in its carbohydrate chain, judging from the results of experiments on glycopeptidase F treatment. The physiological effect of adding mAbL1 (2E12) to cultured mouse dorsal root ganglion neurons was studied using patch-clamp techniques. The binding of mAbL1 (2E12) to the neurons expressing L1 molecule induced an inward current inhibited by calcium channel blockers such as nifedipine and Lanthanum. It was also found that the mAbL1 (2E12) leads to a rise in the intracellular Ca2+ concentration ([Ca2+]i) in cultured neurons. This rise seems to be due to an influx of extracellular Ca2+, since treatment with EGTA abolished those phenomena. L-type calcium channel blockers such as nifedipine and cadmium, as well as inward current, blocked the effect of mAbL1 (2E12). These results suggest that the carbohydrate chain of L1 glycoprotein is directly involved in the induction of calcium current, and that the L1 molecule may play a prominent role in regulation of the Ca2+ channel.
Syndiotactic-Specific Polymerization of 4-Methyl-1,3-pentadiene:  Insertion on a Mt−CH3 Bond (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSyndiotactic-Specific Polymerization of 4-Methyl-1,3-pentadiene: Insertion on a Mt−CH3 BondPasquale Longo, Antonio Proto, Patrizia Oliva, and Adolfo ZambelliView Author Information Dipartimento di Chimica, Università di Salerno, Via S. Allende, I-84081 Baronissi, Salerno, Italy Cite this: Macromolecules 1996, 29, 16, 5500–5501Publication Date (Web):July 29, 1996Publication History Received2 February 1996Revised18 April 1996Published online29 July 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ma960169qhttps://doi.org/10.1021/ma960169qbrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views157Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysts,Monomers,Polymerization,Polymers,Styrenes Get e-Alerts
HOPE-Fixation of Lung Tissue Allows Retrospective Proteome and Phosphoproteome Studies (2014)

Hepes-glutamic acid buffer-mediated organic solvent protection effect (HOPE)-fixation has been introduced as an alternative to formalin fixation of clinical samples. Beyond preservation of morphological structures for histology, HOPE-fixation was demonstrated to be compatible with recent methods for RNA and DNA sequencing. However, the suitability of HOPE-fixed materials for the inspection of proteomes by mass spectrometry so far remained undefined. This is of particular interest, since proteins constitute a prime resource for drug research and can give valuable insights into the activity status of signaling pathways. In this study, we extracted proteins from human lung tissue and tested HOPE-treated and snap-frozen tissues comparatively by proteome and phosphoproteome analyses. High confident data from accurate mass spectrometry allowed the identification of 2603 proteins and 3036 phosphorylation sites. HOPE-fixation did not hinder the representative extraction of proteins, and investigating their biochemical properties, covered subcellular localizations, and cellular processes revealed no bias caused by the type of fixation. In conclusion, proteome as well as phosphoproteome data of HOPE lung samples were qualitatively equivalent to results obtained from snap-frozen tissues. Thus, HOPE-treated tissues match clinical demands in both histology and retrospective proteome analyses of patient samples by proteomics.
Therapeutic effects and adaptive limits of an acellular technique by ultrapurified alginate (UPAL) gel implantation in canine osteochondral defect models (2020)

Although an acellular technique using UPAL gel implantation significantly enhanced osteochondral repair in canines, reparative tissues of the large defect with alginate gel comprised of fibrocartilaginous tissue. This surgical technique is effective, especially for small cartilage injuries. Further improvements are required before clinical application in cases of severe osteochondral defects in humans.
Multi-level security for the 5G/IoT ubiquitous network (2017)

5G, the fifth generation of mobile communication networks, is considered as one of the main IoT enablers. Connecting billions of things, 5G/IoT will be dealing with trillions of GBytes of data. Securing such large amounts of data is a very challenging task. Collected data varies from simple temperature measurements to more critical transaction data. Thus, applying uniform security measures is a waste of resources (processing, memory, and network bandwidth). Alternatively, a multi-level security model needs to be applied according to the varying requirements. In this paper, we present a multi-level security scheme (BLP) applied originally in the information security domain. We review its application in the network domain, and propose a modified version of BLP for the 5G/IoT case. The proposed model is proven to be secure and compliant with the model rules.
Simulation of three-dimensional etch profile of silicon during orientation dependent anisotropic etching (2002)

A simulation program of a three-dimensional anisotropic etching profile is developed to design the fabrication processes of microstructures made of single crystal silicon. We can now predict a change in the shape of a silicon wafer having an arbitrary crystallographic orientation and an initial three dimensional shape including concave and convex edges. Contrary to the conventional method, which assumes that etch profiles are composed of limited crystallographic planes, the developed system makes it possible to use a number of different crystallographic planes. Using this system, we have developed two new processes for fabricating a three-dimensional microstructure. We called them a multi-step anisotropic etching process and a separated anisotropic etching process. This simulation system is a powerful tool for designing the new processes in fabricating three-dimensional microstructures.
Bioresponsive polymer coated drug nanorods for breast cancer treatment (2016)

Ineffective drug release at the target site is among the top challenges for cancer treatment. This reflects the facts that interaction with the physiological condition can denature active ingredients of drugs, and low delivery to the disease microenvironment leads to poor therapeutic outcomes. We hypothesize that depositing a thin layer of bioresponsive polymer on the surface of drug nanoparticles would not only protect drugs from degradation but also allow the release of drugs at the target site. Here, we report a one-step process to prepare bioresponsive polymer coated drug nanorods (NRs) from liquid precursors using the solvent diffusion method. A thin layer (10.3 ± 1.4 nm) of poly(ε-caprolactone) (PCL) polymer coating was deposited on the surface of camptothecin (CPT) anti-cancer drug NRs. The mean size of PCL-coated CPT NRs was 500.9 ± 91.3 nm length × 122.7 ± 10.1 nm width. The PCL polymer coating was biodegradable at acidic pH 6 as determined by Fourier transform infrared spectroscopy. CPT drugs were released up to 51.5% when PCL coating dissolved into non-toxic carboxyl and hydroxyl groups. Trastuzumab (TTZ), a humanized IgG monoclonal antibody, was conjugated to the NR surface for breast cancer cell targeting. Combination treatments using CPT and TTZ decreased the HER-2 positive BT-474 breast cancer cell growth by 66.9 ± 5.3% in vitro. These results suggest effective combination treatments of breast cancer cells using bioresponsive polymer coated drug delivery.
Micro-MRI-based image acquisition and processing system for assessing the response to therapeutic intervention (2006)

Osteoporosis is the cause of over 1.5 million bone fractures annually. Most of these fractures occur in sites rich in trabecular bone, a complex network of bony struts and plates found throughout the skeleton. The three-dimensional structure of the trabecular bone network significantly determines mechanical strength and thus fracture resistance. Here we present a data acquisition and processing system that allows efficient noninvasive assessment of trabecular bone structure through a "virtual bone biopsy". High-resolution MR images are acquired from which the trabecular bone network is extracted by estimating the partial bone occupancy of each voxel. A heuristic voxel subdivision increases the effective resolution of the bone volume fraction map and serves a basis for subsequent analysis of topological and orientational parameters. Semi-automated registration and segmentation ensure selection of the same anatomical location in subjects imaged at different time points during treatment. It is shown with excerpts from an ongoing clinical study of early post-menopausal women, that significant reduction in network connectivity occurs in the control group while the structural integrity is maintained in the hormone replacement group. The system described should be suited for large-scale studies designed to evaluate the efficacy of therapeutic intervention in subjects with metabolic bone disease.
Practical considerations for NMR/MRI in NDT (1994)

Summary form only given: Many diverse nuclear magnetic resonance (NMR) instruments and systems for industrial and other specialized applications have been developed. Many of these systems employ large sample volumes and typically low magnetic fields utilizing various types of magnet configurations, and of different magnet types. Both steady-state NMR and transient NMR techniques provided measurements on a very diverse spectrum of materials, inspection and industrial applications are described. Practical considerations and special techniques required for successful implementation of the technology are discussed. The following areas are included: high RF power generation, probe design for high power, Clark-McNeil transmit-receive networks, electric field effects, selection of magnet types for particular applications, limitations of one-sided access type probes and magnets, considerations in flowing applications, and ruggedized packaging of probes and electronics.
Control Method for Achieving High Power Factor in Single-Phase to Three-Phase Converters without Electrolytic Capacitors (2009)

In this paper, we propose a method for the digital control of IPM motors in order to achieve a high power factor in single-phase to three-phase power converters without reactors or electrolytic capacitors. For achieving the unity power factor under any load condition and any speed condition, we propose a new digital control method that involves the use of a new feedback technique and a new feedforward technique on the source-current regulator side. The proposed digital control system is constructed by using DSP devices. In this paper, we also propose a new method for the compensation of one sampling delay time. The superior performance of the proposed method is demonstrated by experimental results. The experimental results were obtained using 1.5[kW] inverter system, which consists of a vector control system with a 14[μF] dc-link capacitor. The maximum power factor obtained in the experiments was 96.8[%].
Stem Cell Therapy for Retinal Degeneration: Retinal Neurons from Heterologous Sources (2005)

Over the past few years a great deal of interest has been generated in using stem cells/progenitors to treat degenerative diseases that afflict different tissues, including retina. This interest is due to the defining properties of stem cells/progenitors, the ability of these cells to self-renew and generate all the basic cell types of the particular tissue to which they belong. In addition, the recent reports of plasticity of the adult tissue-specific stem cells/progenitors and directed differentiation of the embryonic cells (ES) has fueled the hope for cell and gene therapy using stem cells from heterologous sources. Will this approach work for treating retinal degeneration? Here, we review the current state of knowledge about obtaining retinal cells from heterologous sources, including ES cells.
Sandmeyer Trifluoromethylation of Arenediazonium Tetrafluoroborates (2013)

Copper capabilities: Diazonium salts are converted into the corresponding trifluoromethyl derivatives in the presence of a trifluoromethyl–copper complex generated in situ from CuSCN and the inexpensive, easy-to-use trifluoromethylating reagent Me3Si-CF3 (see scheme). This Sandmeyer-type reaction allows the straightforward synthesis of trifluoromethylated arenes and heteroarenes from the corresponding amines.
Modelling of waves and ocean currents for real-time simulation of ocean dynamics (2007)

Real-time models of ocean dynamics are very useful for the design, development, testing and validation of marine technology in simulation. Many models of waves and currents are proposed in the literature, ranging from very simple to very complex models. In order to accommodate these models for realtime simulation of ocean dynamics, balance needs to be achieved between complexity of the model and constraints imposed by the requirement for synchronization with real-time. This paper presents models of waves and currents that are simple enough to fulfil real-time requirements, while general enough to describe most phenomena of interest. Mathematical models of forces and moments, exerted by these disturbances, are used to examine the behaviour of marine platforms/vessels in near real-world scenarios.
A Survey of Latency Reducing Techniques and their Merits (2013)

This position paper gives a status report on work we have recently started to survey techniques for reducing the delays in communications. The immediate aim is to organise all the techniques into a meaningful categorisation scheme, then to quantify the benefit of each approach and produce visualisations that highlight those approaches that are likely to be most fruitful.
Développement de peptidomimétiques antagonistes du récepteur de l’interleukine-1β (2012)

Dans ce mémoire, je présente mes études sur la synthèse, la caractérisation et l’évaluation biologique de différentes séries d’analogues du D-heptapeptide appelé 101.10, un modulateur négatif allostérique du récepteur de l’interleukine-1β (IL-1β). Sachant que les peptides ont généralement de faibles propriétés pharmacologiques, le but de ce projet portait sur l’examen des structures nécessaires à la bioactivité, la conformation tridimensionnelle de ces derniers afin d’améliorer la droguabilité du peptide parent. Les stratégies d’optimisation du 101.10 utilisées furent : la coupure N- et C-terminale; la substitution par la proline, α-amino-γ-lactame (Agl), β-amino-γ-lactame (Bgl) et α-amino-β-hydroxy-γ-lactame (Hgl); et la rigidification du squelette à l’aide d’un bicycle, l’indolozidin-2-one (I2aa). Afin de clarifier certaines relations de structure-activité, quelques modifications furent apportées au peptide, incluant l’échange de la thréonine pour la valine, la permutation de la stéréochimie de certains résidus clés ainsi que le remplacement de certaines chaînes latérales par un méthyle. Pour pallier aux difficultés de reproductibilité des résultats avec des échantillons provenant de différentes sources, des études sur l’identité du contre-anion et la pureté du peptide furent conduites. Afin d’évaluer l’effet des modifications sur la conformation aqueuse et l’activité biologique du peptide, des analyses de dichroïsme circulaire et des tests in vitro mesurant l’inhibition de certains effets de l’IL-1β furent effectués. Ces essais cellulaires comportaient l’inhibition de la prolifération de cellules immunes et de l’activation des voies de signalisation inflammatoires du facteur nucléaire κB (NF-κB) et de la protéine kinase activée par mitogène (MAPK), toutes deux stimulées par l’IL-1β. La compilation de ces données a permis de déceler certaines tendances entre la structure, la conformation et l’activité anti-IL-1β des peptidomimétiques.
Making workstations a friendly environment for batch jobs (2003)

It is argued that batch processing is not something of the past or something which applies only to mainframe computers, but that distributed batch processing on workstations in an area of considerable and increasing importance, and as such should be given serious consideration by operating system designers. The most important of the services found lacking are detailed. The reasons why these services are important and the need for the services to be presented in a uniform way across platforms are shown.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>