gebhart/patrepeval huggingface dataset:
Energy Efficient Altitude Optimization of an Aerial Access Point (2020)

In this paper, we propose an energy-efficient optimal&lt;br&gt;altitude for an aerial access point (AAP), which acts as a flying&lt;br&gt;base station to serve a set of ground user equipment (UE).&lt;br&gt;Since the ratio of total energy consumed by the aerial vehicle&lt;br&gt;to the communication energy is very large, we include the&lt;br&gt;aerial vehicle’s energy consumption in the problem formulation.&lt;br&gt;After considering the energy consumption model of the aerial&lt;br&gt;vehicle, our objective is translated into a non-convex optimization&lt;br&gt;problem of maximizing the global energy efficiency (GEE)&lt;br&gt;of the aerial communication system, subject to altitude and&lt;br&gt;minimum individual data rate constraints. At first, the nonconvex fractional objective function is solved by using sequential&lt;br&gt;convex programming (SCP) optimization technique. To compare&lt;br&gt;the result of SCP with the global optimum of the problem,&lt;br&gt;we reformulate the initial problem as a monotonic fractional&lt;br&gt;optimization problem (MFP) and solve it using the polyblock&lt;br&gt;outer approximation (PA) algorithm. Numerical results show that&lt;br&gt;the candidate solution obtained from SCP is the same as the&lt;br&gt;global optimum found using the monotonic fractional programming technique. Furthermore, the impact of the aerial vehicle’s&lt;br&gt;energy consumption on the optimal altitude determination is also&lt;br&gt;studied &lt;br&gt;
Exploring Customizable Heterogeneous Power Distribution and Management for Datacenter (2018)

Large-scale datacenters are facing increasing pressure of capping their carbon emission and power cost. Many leading-edge studies have started to explore server clusters running on multiple power sources. Existing approaches do not sufficiently consider the fine-grained power delivery to satisfy diverse requirements in datacenter, especially in the multi-tenant/colocation datacenter, which may yield low energy utilization. To address the emerging trend and new requirements, this article proposes a novel Datacenter inner Power Switch Network (DiPSN) to improve datacenter power efficiency and user satisfaction. DiPSN is a reconfigurable and easy-to-scale-out power architecture, which enables datacenter to distribute various power sources in a fine-grained manner. Moreover, a tailored machine learning based power source management framework is proposed for DiPSN to dynamically optimize user customized performance metrics and maximize datacenter revenue. Compared with conventional single-switch power distribution system, our DiPSN can be configured to improve solar energy utilization by 39.6 percent, reduce utility power cost by 11.1 percent and improve workload performance by 33.8 percent. Meanwhile, our design can extend battery lifetime by 9.3 percent. This work could provide valuable guidelines for designing heterogeneous power distribution architecture and management methodology in datacenters for improving user-customizable efficiency, sustainability and economy.
The Effect of Heat Generation from Bone Cement on Bone Tissue in Total Knee Arthroplasty. (1998)

Bone cement is often applied to fix the components in a surgical operation, such as TKA (total knee arthroplasty). In this paper, we consider the effect of heat generation from bone cement on bone tissue in TKA by using numerical simulation. First, we applied an axisymmetric model of tibia to finite element method and analyzed heat generation of bone cement. To confirm the results of analysis by experiment, we measured the temperature determined by 6 points i. e., 2 points each in component-cement interface, cement and bone-cement interface. As a result, the temperature determined by analysis agrees with that determined by experiment. Next, we proposed the evaluation formura of the bone necrosis. We constructed a bone necrosis map from the simulation. From the map, we found that the bone necrosis region was about 2 mm from the bone-cement interface. In addition, the bone necrosis is severe at the base of the tibial component.
Aviation in discrimination [i.e. Discrimination in aviation] (2000)

This study questions the effects that discrimination has had on aviation and what changes, if any, can be expected in the near future. The central theme of the study is discrimination, specifically racial discrimination, sex discrimination and age discrimination. Of particular importance is the discriminatory role that various government agencies have played in labeling a person unfit to serve as a pilot simply because that person happens to be a woman, black or has reached a certain chronological age.
Extending the Bioavailability of Hydrophilic Antioxidants for Metal Ion Detoxification via Crystallization with Polysaccharide Dopamine (2022)

Although metal ions, such as silver and gold, have been shown to have strong antimicrobial properties, their potential to have toxic effects on human and environmental health has gained interest with an improved understanding of their mechanisms to promote oxidative stress. Redox control is a major focus of many drug delivery systems and often incorporates an antioxidant as the active pharmaceutical ingredient (API) to neutralize overproduced reactive oxygen species (ROS). Nevertheless, there are still limitations with bioavailability and extended redox control with regard to antioxidant drug delivery. Herein, this study develops a colloidal antioxidant crystal system that dissolves sustainably through polymer stabilization using sodium hyaluronate conjugated with dopamine (HA-dopa). We explore the role of dopamine incorporation into crystal-stabilizing polymers and quantify the balance between drug-polymer interactions and competing polymer-polymer interactions. We propose that this type of analysis is useful in the engineering of and provides insight into the release behavior of polymer-crystal complexes. In developing our crystal complex, <i>N</i>-acetylcysteine (NAC) was used as the model antioxidant to protect against silver ion toxicity. We found that our optimized HA-dopa-stabilized NAC crystals prolong the release time of NAC 5-fold compared to a polymer-free NAC crystal. Therefore, following sublethal exposure to AgNO<sub>3</sub>, the extended lifetime of NAC was able to maintain normal intracellular ROS levels, modulate metabolic function, mitigate fluctuations in ATP levels and ATP synthase activity, and preserve contraction frequency in engineered cardiac muscle tissue. Furthermore, the protective effects of the HA-dopa-stabilized NAC crystals were extended to a <i>Daphnia magna</i> model where silver-ion-induced change to both cell-level biochemistry and organ function was alleviated. As such, we propose that the packaging of hydrophilic antioxidants as colloidal crystals drastically extends the lifetime of the API, better maintains ROS homeostasis post metal ion exposure, and therefore preserves both intracellular biochemistry and tissue functionality.
Discovery of Metabolic Biomarkers for Duchenne Muscular Dystrophy within a Natural History Study (2016)

Serum metabolite profiling in Duchenne muscular dystrophy (DMD) may enable discovery of valuable molecular markers for disease progression and treatment response. Serum samples from 51 DMD patients from a natural history study and 22 age-matched healthy volunteers were profiled using liquid chromatography coupled to mass spectrometry (LC-MS) for discovery of novel circulating serum metabolites associated with DMD. Fourteen metabolites were found significantly altered (1% false discovery rate) in their levels between DMD patients and healthy controls while adjusting for age and study site and allowing for an interaction between disease status and age. Increased metabolites included arginine, creatine and unknown compounds at m/z of 357 and 312 while decreased metabolites included creatinine, androgen derivatives and other unknown yet to be identified compounds. Furthermore, the creatine to creatinine ratio is significantly associated with disease progression in DMD patients. This ratio sharply increased with age in DMD patients while it decreased with age in healthy controls. Overall, this study yielded promising metabolic signatures that could prove useful to monitor DMD disease progression and response to therapies in the future.
Teicoplanin metabolism in rats (1989)

This study was done to see whether teicoplanin undergoes metabolic transformation in rats. Sprague-Dawley rats were given 7.6 mg of [14C]teicoplanin (904 U/mg, 7.6 muCi/mg) per kg intravenously; 73.2 +/- 4.0% of the administered radioactivity and 59.1 +/- 4.8% of the administered microbiological activity were recovered in the 24-h urine samples. The difference between these two values was due to adsorption of teicoplanin to the urinary sediment, making some of the antibiotic not available for microbiological determination. In fact, after a sample or urine was filtered through an Acrodisc (0.45 micron pore size), radiochemical and microbiological data for the filtrate were very similar. Possible metabolites were looked for by high-performance liquid chromatographic analysis of the teicoplanin complex composition in the urine samples, with both UV and radioactivity detection. The quantitation, based on the 14C percentage in each peak, showed that no more than 3 to 5% of the [14C]teicoplanin underwent metabolic and/or chemical transformation.
Combining boundary‐conforming finite element meshes on moving domains using a sliding mesh approach (2020)

Abstract For most finite element simulations, boundary‐conforming meshes have significant advantages in terms of accuracy or efficiency. This is particularly true for complex domains. However, with increased complexity of the domain, generating a boundary‐conforming mesh becomes more difficult and time consuming. One might therefore decide to resort to an approach where individual boundary‐conforming meshes are pieced together in a modular fashion to form a larger domain. This article presents a stabilized finite element formulation for fluid and temperature equations on sliding meshes. It couples the solution fields of multiple subdomains whose boundaries slide along each other on common interfaces. Thus, the method allows to use highly tuned boundary‐conforming meshes for each subdomain that are only coupled at the overlapping boundary interfaces. In contrast to standard overlapping or fictitious domain methods the coupling is broken down to few interfaces with reduced geometric dimension. The formulation consists of the following key ingredients: the coupling of the solution fields on the overlapping surfaces is imposed weakly using a stabilized version of Nitsche's method. It ensures mass and energy conservation at the common interfaces. Additionally, we allow to impose weak Dirichlet boundary conditions at the nonoverlapping parts of the interfaces. We present a detailed numerical study for the resulting stabilized formulation. It shows optimal convergence behavior of the interface coupling for both Newtonian and generalized Newtonian material models. Simulations of flow of plastic melt inside single‐screw as well as twin‐screw extruders demonstrate the applicability of the method to complex and relevant industrial applications.
DSM in practice: iterative water-filling implemented on ADSL modems (2004)

Dynamic spectrum management (DSM) is a new technique for multiuser power allocation and/or detection in digital subscriber line (DSL) networks. In DSM, transmit spectra are adapted based on the direct and crosstalk channels seen by the modems within a network. This allows binder bit rate performance maximisation. At the Alcatel Research and Innovation labs, we have recently developed a DSM testbed which allows the performance of DSM algorithms to be evaluated in practice. The paper describes the development of this DSM testbed. With this testbed we have evaluated the performance of a DSM algorithm known as iterative water-filling. It has been demonstrated that iterative water-filling can yield data-rate gains of up to 500% in the real world. Practical issues on the implementation of iterative water-filling are also discussed.
Reliability assessment of a large population of 3.3 kV, 45 A 4H-SIC MOSFETs (2017)

In this work, we report results for the 3 lot, 77 device-per-lot high temperature-reverse bias (HTRB) test, as well as work on gate oxide reliability for 3.3 kV devices in relation to the presence of material defects. The work indicates that large scale reliable operation of 3.3 kV 4H-SIC MOSFETs is achievable using conventional 4H-SiC device processing techniques and DMOS device structures, despite the prevalence of measurable surface morphology on 3.3 kV SiC epilayers. No correlation was found between dislocation content and MOS capacitor breakdown field, measured on over 14 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> of combined tested 4H-SIC MOS gate area.
Nuevos aspectos en el tratamiento de la dependencia de la heroína con referencia especial a los aspectos neurobiológicos (2002)

Resumen Los ensayos suizos sobre la prescripción médica de diacetilmorfina inyectable (heroína farmacéutica) para la dependencia “grave” de la heroína provocaron comentarios muy polémicos. A pesar de las limitaciones metodológicas, la evaluación de los ensayos de heroína suizos produjo algunos hallazgos interesantes. Los participantes en el estudio mostraron mejorías sustanciales en la salud y el bienestar y disminuciones sensibles en el uso de drogas ilegales y actividades delictivas. Así, la prescripción de heroína puede ser útil para algunos de los que continúan utilizando regularmente heroína ilegal mientras están en mantenimiento con metadona o rechazan otras opciones de tratamiento disponibles. Sin embargo, los datos basados en la investigación indican que la aplicación intravenosa (IV) de heroína bajo supervisión médica puede tener efectos secundarios adversos. Estudios recientes han mostrado que las inyecciones de heroína producen disminuciones pasajeras pero significativas en la oxigenación sistémica y cortical, muy probablemente secundarias a la depresión respiratoria. Estos efectos, entre otros, son objeto de estudios en curso.
Grain Boundary Sliding Measurements during Tensile Creep of a Single‐Phase Alumina (1998)

The grain boundary sliding (GBS) behavior of a single‐phase (relatively coarse‐grained) alumina material was studied after tensile creep experiments were performed at 1500°C at stress levels of 20 and 35 MPa. Specimens tested at 35 MPa exhibited a number of modes of GBS, including Mode II (shear) displacements, Mode I (opening) displacements, out‐of‐plane sliding displacements, and in‐plane grain rotation. Strains in the grain boundaries due to Mode II GBS ranged from 940% to 4400%. Average Mode II GBS displacements ranged from 0.08 to 0.29 µm in samples tested for 120 and 480 min, respectively, at 35 MPa. The GBS displacements were shown to fit a Weibull distribution. Tensile creep under a 35 MPa stress yielded a GBS rate of 9.5 10 ‐6 µm/s, while the 20 MPa stress resulted in a GBS rate of 2.2 10 ‐6 µm/s. The average Mode II GBS displacements increased linearly with specimen strain, suggesting that GBS may play an important role in creep cavitation during tensile creep. The data also revealed that compatibility and constraint rules appear to govern GBS behavior during tensile creep. GBS behavior during compressive creep will be compared to the tensile creep GBS measurements presented.
Single-Input Multiple-Output Converter for CubeSat Electric Power System (2022)

The objective of this paper is to present a new multiport converter with one input and multiple outputs for CubeSat electric power system (EPS). State-of-the-art EPS utilizes multiple power converters for tracking the maximum power output of PV panels and voltage regulation of loads. This leads to utilization of multiple bulkier inductors in the CubeSat EPS and thus, increasing the converter footprint. The proposed SIMO converter integrates the PV panels, energy storage, and the dc-dc converters with a single inductor and thus, it reduces the converter footprint compared to conventional CubeSat EPS. To demonstrate the operation of the proposed converter, a simulation model is developed in MATLAB Simulink using the parameters of 1U CubeSat and it is tested both in steady-state and dynamic conditions.
Addition of Grignard Reagents to Chiral 1,2-Bisimines: A Diasteroselective Preparation of Unsymmetrical 1,2-Diamines (2000)

A diastereoselective synthesis of tert-butyl-1,2-diamines has been developed from the addition of tert-butylmagnesium chloride to the 1,2-bisimines derived from glyoxal and chiral amines such as 1-(S)-ethylphenylamine, 1-(S)-phenylpropylamine or 1-(S)-(p-chlorophenyl)ethylamine. The influence of solvent, temperature and chiral auxiliaries on the chemical reactivity and stereoselectivity has been fully studied. Evidence of a dynamic kinetic resolution during the bis-addition process of the organometallic, leading to the 1,2-di-tert-butylethanediamine,[1] as a single diastereomer, has been demonstrated. This resolution has been applied with high diastereoselectivities to the synthesis of unsymmetrical disubstituted 1,2-diamines, by addition of one equivalent of tert-butylmagnesium chloride, followed by one equivalent of a second Grignard reagent. Several chiral 1-tert-butyl-1,2-diamines have also been synthesized by monoaddition of tert-butylmagnesium chloride to the bisimines, followed by hydride reduction of the chiral intermediate imines.
Cake Cam (2019)

Tourists often turn to strangers when they need a photographer while traveling; however, they do so at a cost. Strangers are not typically trained photographers, nor are they telepathically intuiting what composition the tourist wants. Existing smartphone camera interfaces do not communicate the desired framing to the stranger, and prior work in mobile photography guidance does not manage the 3D movement required when composing the tourist's ideal photo. We offer a new kind of mobile interaction for communicating the intended photo to a stranger without instructions. In our methodology, the tourist first composes a photo with the desired framing. The app, Cake Cam, then stores the camera position and orientation. Finally, 3D augmented reality markers guide the stranger to retake the photo with the tourist now standing in the frame. Our study resulted in more accurate camera placements and required fewer additional instructions than the traditional tourist photography method (n=40).
Overexpression of CLIC1 in human gastric carcinoma and its clinicopathological significance (2006)

Gastric cancer is the second most common cancer worldwide and the fifth leading cause of cancer-related death in Taiwan. Identification of biomarkers is essential to improve patient survival. Fifty aberrantly expressed proteins were identified using 2-DE combined with MALDI TOF MS and were grouped based on their function. The overexpression of proteins was confirmed using real-time quantitative RT-PCR, Western blot, and immunohistochemical analysis. The clinicopathological correlations and prognostic significance of these aberrantly expressed proteins were evaluated to determine the novel gastric cancer biomarkers. In this study, expression of chloride intracellular channel 1 (CLIC1) is significantly up-regulated in 67.9% of gastric patients and was selected for further study. The CLIC1 expression in tumor tissues was increased by 1.95-fold (range, 0.01-6.19-fold) compared with that expressed by adjacent noncancerous mucosa. Elevated CLIC1 expression was strongly correlated with lymph node metastasis, lymphatic invasion, perineural invasion, and pathological staging. Additionally, the 5-year survival rate for the low CLIC1 expression group (n = 28; <1.72-fold) was higher than that for the high CLIC1 expression group (n = 28; >or=1.72-fold) (log rank, p = 0.0300). Experimental results indicate that overexpression of CLIC1 is a potential prognostic marker for gastric cancer.
Data collection, storage, and retrieval with an underwater sensor network (2005)

In this paper we present a novel platform for underwater sensor networks to be used for long-term monitoring of coral reefs and fisheries. The sensor network consists of static and mobile underwater sensor nodes. The nodes communicate point-to-point using a novel high-speed optical communication system integrated into the TinyOS stack, and they broadcast using an acoustic protocol integrated in the TinyOS stack. The nodes have a variety of sensing capabilities, including cameras, water temperature, and pressure. The mobile nodes can locate and hover above the static nodes for data muling, and they can perform network maintenance functions such as deployment, relocation, and recovery. In this paper we describe the hardware and software architecture of this underwater sensor network. We then describe the optical and acoustic networking protocols and present experimental networking and data collected in a pool, in rivers, and in the ocean. Finally, we describe our experiments with mobility for data muling in this network.
Nano optics and atomics : transport of light and matter waves : Varenna on Lake Como, Villa Monastero, 23 June–3 July, 2009 (2011)

Many fundamental processes in physics involve transport and the spectacular progress in the control and engineering of matter at the nano-scale has meant that new regimes of wave transport have been the subject of great interest in recent decades. This book presents a collection of contributions from speakers and lecturers at the CLXXIII International School of Physics Enrico Fermi, held in Varenna, Italy, in June 2009. Different aspects of wave transport were covered during the school, from electrons to light propagation and from sound to ultra-cold atoms. The school was characterized by a strong interdisciplinary approach, with speakers, lecturers and students from different communities sharing their knowledge and their often complimentary points of view and approaches. Subjects covered in the book include: Anderson localization; photonic properties of non-crystalline solids; diffuse optics; ultrasonic wave transport in strongly scattering media; multi-wave imaging; time reversal focusing and the diffractional limit, as well as strongly correlated quantum phases of ultra-cold atoms in optical lattices.
Nanoparticles Encapsulated with LL37 and Serpin A1 Promotes Wound Healing and Synergistically Enhances Antibacterial Activity (2016)

Wound care is a serious healthcare concern, often complicated by prolonged inflammation and bacterial infection, which contributes significantly to mortality and morbidity. Agents commonly used to treat chronic wound infections are limited due to toxicity of the therapy, multifactorial etiology of chronic wounds, deep skin infections, lack of sustained controlled delivery of drugs, and development of drug resistance. LL37 is an endogenous host defense peptide possessing antimicrobial activity and is involved in the modulation of wound healing. Serpin A1 (A1) is an elastase inhibitor and has been shown to demonstrate wound-healing properties. Hence, our goal was to develop a topical combination nanomedicine for the controlled sustained delivery of LL37 and A1 at precise synergistic ratio combinations that will significantly promote wound closure, reduce bacterial contamination, and enhance anti-inflammatory activity. We have successfully developed the first solid lipid nanoparticle (SLN) formulation that can simultaneously deliver LL37 and A1 at specific ratios resulting in accelerated wound healing by promoting wound closure in BJ fibroblast cells and keratinocytes as well as synergistically enhancing antibacterial activity against S. aureus and E. coli in comparison to LL37 or A1 alone.