gebhart/patrepeval huggingface dataset:
Anti‐cancer potential of selenium‐chitosan‐polyethylene glycol‐carvacrol nanocomposites in multiple myeloma U266 cells (2023)

Multiple myeloma (MM) is an incurable cancer that is characterized by malignant plasma cell proliferation. Approximately 10% of all blood cancers are MM, and there is no standard curative therapy. In this work, we intended to synthesize, characterize, and assess the anticancer effects of selenium/chitosan/polyethylene glycol-carvacrol nanocomposites (SCP-Car-NCs) on MM U266 cells in vitro. Various characterization techniques were used to characterize the synthesized SCP-Car-NCs. Several in vitro free radical scavenging experiments were conducted to test the ability of synthesized SCP-Car-NCs to scavenge the different free radicals. The cytotoxicity of SCP-Car-NCs was assessed on Vero and U266 cells using the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay. By using various fluorescence staining techniques, the amount of reactive oxygen species (ROS) generation, MMP, and apoptosis were measured. Using commercial test kits, the levels of oxidative stress and apoptotic biomarkers in control and treated U266 cells were assessed. The highest peak in the UV spectral analysis was found to be at 271 nm, demonstrating the development of SCP-Car-NCs. Fourier transform infrared analysis showed that the synthesized SCP-Car-NCs contained a variety of stretching and bonding. The X-ray diffraction study confirmed the crystallinity of SCP-Car-NCs. The dynamic light scattering analysis showed that the SCP-Car-NCs had an average size of 171 nm. The different free radicals, such as the 2,2-diphenyl-1-picrylhydrazyl, hydroxyl, and peroxyl radicals, were significantly scavenged by the SCP-Car-NCs. According to the MTT assay results, the SCP-Car-NCs decreased the viability of U266 cells while having no impact on the proliferation of Vero cells. The SCP-Car-NCs significantly boosted ROS production, decreased the MMP level, and promoted apoptosis, as evidenced by the fluorescence staining experiments. In U266 cells treated with SCP-Car-NCs, the level of thiobarbituric acid reactive substances increased while superoxide dismutases and glutathione levels were reduced. In the SCP-Car-NCs treated U266 cells, it was found that the Bax, caspase-3, and -9 activities had increased while the Bcl-2 level had decreased. In conclusion, our findings show that SCP-Car-NCs treatment reduced the viability and increased apoptosis in the U266 cells, providing a new insight on SCP-Car-NCs' potential for usage in the future to treat MM.
Modeling and Design of Millimeter-Wave Networks for Highway Vehicular Communication (2017)

Connected and autonomous vehicles will play a pivotal role in future intelligent transportation systems and smart cities, in general. High-speed and low-latency wireless communication links will allow municipalities to warn vehicles against safety hazards, as well as support cloud-driving solutions to drastically reduce traffic jams and air pollution. To achieve these goals, vehicles need to be equipped with a wide range of sensors generating and exchanging high rate data streams. Recently, millimeter wave (mmWave) techniques have been introduced as a means of fulfilling such high data rate requirements. In this paper, we model a highway communication network and characterize its fundamental link budget metrics. In particular, we specifically consider a network where vehicles are served by mmWave base stations (BSs) deployed alongside the road. To evaluate our highway network, we develop a new theoretical model that accounts for a typical scenario where heavy vehicles (such as buses and lorries) in slow lanes obstruct line-of-sight (LOS) paths of vehicles in fast lanes and, hence, act as blockages. Using tools from stochastic geometry, we derive approximations for the signal-to-interference-plus-noise Ratio (SINR) outage probability, as well as the probability that a user achieves a target communication rate (rate coverage probability). Our analysis provides new design insights for mmWave highway communication networks. In considered highway scenarios, we show that reducing the horizontal beamwidth from 90° to 30° determines a minimal reduction in the SINR outage probability (namely 4 · 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> at maximum). Also, unlike bidimensional mmWave cellular networks, for small BS densities (namely one BS every 500 m) it is still possible to achieve an SINR outage probability smaller than 0.2.
Activity of (+)-Discadenine as a Plant Cytokinin (2017)

Discadenine (1), a self-spore germination inhibitor from the cellular slim mold Dictyostelium discoideum, is structurally related to the plant hormone cytokinin. This compound was synthesized from l-aspartic acid, and its activities were confirmed by three classical cytokinin bioassays as well as by using binding and activation assays with the Arabidopsis cytokinin receptors AHK3 and CRE1/AHK4.
Process for CO.sub.2 capture using a regenerable magnesium hydroxide sorbent (2023)

A process for CO.sub.2 separation using a regenerable Mg(OH).sub.2 sorbent. The process absorbs CO.sub.2 through the formation of MgCO.sub.3 and releases water product H.sub.2O. The MgCO.sub.3 is partially regenerated through direct contact with steam, which acts to heat the magnesium carbonate to a higher temperature, provide heat duty required to decompose the magnesium carbonate to yield MgO and CO.sub.2, provide an H.sub.2O environment over the magnesium carbonate thereby shifting the equilibrium and increasing the potential for CO.sub.2 desorption, and supply H.sub.2O for rehydroxylation of a portion of the MgO. The mixture is polished in the absence of CO.sub.2 using water product H.sub.2O produced during the CO.sub.2 absorption to maintain sorbent capture capacity. The sorbent now comprised substantially of Mg(OH).sub.2 is then available for further CO.sub.2 absorption duty in a cyclic process.
Isozyme variation and inheritance in blueberry (1988)

Leaf tissue extracts from diploid, tetraploid, and hexaploid species of blueberry, Vaccinium section Cyanococcus, were electrophoretically analyzed for isozyme polymorphism in 12 enzyme systems. Aldolase, shikimate dehydrogenase, triose phosphate isomerase, glucose-6-phosphate dehydrogenase, phosphoglucomutase, aconitase, alcohol dehydrogenase, and aspartate aminotransferase showed activity, but banding was not clear. Four enzymes, malate dehydrogenase (MDH), phosphoglucose isomerase (PGI), 6-phosphogluconate dehydrogenase (6-PGD), and isocitrate dehydrogenase (IDH), exhibited interpretable banding patterns. Two loci were apparent for MDH, PGI, and 6-PGD and one for IDH. Polymorphism was detected at Mdh-2, Pgi-2, 6-Pgd-2, and Idh. Three allozymes were found at Mdh-2 and Idh and at least four at Pgi-2 and 6-Pgd-2. Allozyme segregation ratios observed in progeny of controlled diploid crosses supported single-gene Mendelian inheritance. Banding patterns of all allozymes indicated a dimeric structure for these four enzymes. It appears that all alleles at multiallelic loci are expressed in polyploids. Preliminary data suggest that allozyme analyses may be useful in taxonomic studies in blueberry.Key words: Vaccinium, allozymes, inheritance, electrophoresis.
Cardiac Magnetic Resonance Evaluation of the Extent of Myocardial Injury in Patients with Inferior ST Elevation Myocardial Infarction and Concomitant ST Depression in Leads V1–V3: Analysis from the MITOCARE Study (2018)

STD in V1-V3 in iSTEMI is associated with larger MaR, more extension into the inferoseptal segments and likely results from greater frontal plane projection of the MaR, leading to reciprocal changes on the electrocardiogram.
113 Dyskinesis index by strain analysis - a new and early reperfusion marker (2003)

Multiples indices have recently been described using tissue Doppler imaging (DTI).The relevance of these indices in the routine management of patients with an acute myocardial infarction (AMI) remains poorly evaluated.We sought to analyze patients by transthoracic echocardiography and regional DTI analysis after coronary angiography (CA).Methods: 28 consecutive patients (6114 years old) were imaged in the 24 hours following the PTCA for AMI.17 control subjects with normal CA (4911 years old) were studied as well.Global and regional left ventricular function were analyzed.High frame rate color DTI cineloop were recorded in apical 4 and 2 chambers for subsequent analyses of regional myocardial velocities and gradients, at 4 levels.Results: 15 patients were successfully treated for anterior AMI and 13 for an inferior one.Figure 1 displayed the ROC curve in regard to the ability of DTI parameters to predict the territory vascularized by a pathologic coronary artery.The combination ICT & IVRT had 74% sensitivity and 68% specificity determining the pathologic artery, looking only at values obtained in the mid-segment of each LV wall.IVRT peak velocity was negative in control segments (segments related to no coronary artery stenosis, -0.700.99cm/s for the mean anterior wall) and became positive and delayed in ischemic segments (0.640.65 cm/s for the mean anterior wall, p<0.001).Also, regional velocities and gradients were significantly depressed in the AMI group compared to the normal one.Conclusion: IVR & IVC peak velocity were strikingly informative.Strain & strain rate are, for us, less useable in clinical practice because signal/noise ratio & difficulties to define systolic and post-systolic events without any phonocardiogram.
Development of sources and a testbed for CERTS microgrid testing (2004)

The development of the CERTS microgrid concept is discussed, in addition to discussion of modifications necessary to the controls of microsources (microturbines, for example) that are necessary for operation in the CERTS microgrid. Also described is a testbed that will be constructed to test the CERTS microgrid concept.
Controlling Experience or Experiencing Control?: Reversal Theory & Design for Play (2019)

Using Reversal Theory (Apter, 2002, 2007a) as an example this paper proposes a way to ‘translate’ a psychological concept into the realm of design in a way that maximizes understanding and potential for application in the context of play. The given presentation of Reversal Theory is the result of the analysis of student’s use of available sources in idea development for play in children. The description aims to enhance the usability of the concept by providing a modular presentation of aspects which could be used in isolation but reach their full potential when integrated. Different options to use this modular framework in design tutoring are discussed. The project is seen as a step towards increasing the use of current psychological concepts to inform design for play.
Substrate specificity of transthyretin: identification of natural substrates in the nervous system (2009)

Besides functioning as the plasma transporter of retinol and thyroxine, TTR (transthyretin) is a protease, cleaving apoA-I (apolipoprotein A-I) after a phenylalanine residue. In the present study, we further investigated TTR substrate specificity. By using both P-diverse libraries and a library of phosphonate inhibitors, a TTR preference for a lysine residue in P1 was determined, suggesting that TTR might have a dual specificity and that, in addition to apoA-I, other TTR substrates might exist. Previous studies revealed that TTR is involved in the homoeostasis of the nervous system, as it participates in neuropeptide maturation and enhances nerve regeneration. We investigated whether TTR proteolytic activity is involved in these functions. Both wild-type TTR and TTR(prot-) (proteolytically inactive TTR) had a similar effect in the expression of peptidylglycine alpha-amidating mono-oxygenase, the rate-limiting enzyme in neuropeptide amidation, excluding the involvement of TTR proteolytic activity in neuropeptide maturation. However, TTR was able to cleave amidated NPY (neuropeptide Y), probably contributing to the increased NPY levels reported in TTR-knockout mice. To assess the involvement of TTR proteolytic activity in axonal regeneration, neurite outgrowth of cells cultivated with wild-type TTR or TTR(prot-), was measured. Cells grown with TTR(prot-) displayed decreased neurite length, thereby suggesting that TTR proteolytic activity is important for its function as a regeneration enhancer. By showing that TTR is able to cleave NPY and that its proteolytic activity affects axonal growth, the present study shows that TTR has natural substrates in the nervous system, establishing further its relevance in neurobiology.
Response to Zeman (2014)

Kazi, Abdul M.; MacVittie, Thomas J.; Lasio, Giovanni; Lu, Wei; Prado, Karl L. Author Information
Spontaneous photoinduced patterning of azo-dye polymer films: the facts (2007)

We describe the spontaneous photoinduced patterning of azo-dye polymer films. We have observed that the illumination of an azo-dye polymer film by a uniform single laser beam with normal incidence leads to a self-structurization process that results in the formation of well-ordered submicrometer-sized structures whose organization depends on the light polarization direction. A modulation depth as high as 100 nm can be achieved. The influence of several experimental parameters on the structure formation is studied. Results are discussed and confronted to different models and phenomena already investigated in the literature. A physical origin to this peculiar photopatterning process is proposed.
Revisiting regulatory T cells for stroke therapy (2022)

Stroke is a leading cause of death and long-term disability. T cells have been extensively studied for their dual role in regulating immunity and inflammation following stroke. In this issue of the JCI, Cai, Shi, et al. demonstrated that CD8+ regulatory-like T cells (CD8+ TRLs) are one of the earliest lymphocyte subtypes to enter the brain after experimental ischemic stroke. Using a mouse model of stroke and comprehensive experimental approaches, the authors found that CD8+ TRLs reduced both brain damage and functional deficits in both young and aged mice. These unique early responding regulatory T cells may also play a role in a wide array of other T cell-mediated neurological disorders.
Real-Time Decision Support with Reinforcement Learning for Dynamic Flowshop Scheduling (2017)

The dynamic flowshop scheduling problem has attracted a lot of attention from both academia and industry because of its nature of NP-hardness in computation on the one hand, and its great value for optimization of manufacturing systems on the other. Traditionally, effective heuristic methods have been widely adopted in industry to solve the problem. In recent years, machine learning has also exhibited great potential in the field. In this paper, we propose a reinforcement learning approach to this problem. We discuss settings for orders, performance measurements, and learning methods in detail to construct a controlled environment for this research. We then establish a manufacturing simulation system to compare the performance of the reinforcement learning approach and three heuristic approaches. While the experimental results revealed the superiority of the reinforcement learning method, investigations into dispatching decisions exposed its limitations in actual industry applications. Hence, two strategies were designed and employed to improve the reinforcement learning approach. After validating the reinforcement learning method with the improved strategies, we summarized and presented the dispatching rules of the reinforcement learning method as one type of complementary decision for supporting real-time flowshop scheduling problems.
ICI 182,780 (Fulvestrant)--the first oestrogen receptor down-regulator--current clinical data. (2001)

ICI 182,780 (Fulvestrant) is the first in a new class of novel, steroidal, 'pure' antioestrogens--the oestrogen receptor (ER) down-regulators. Its unique mode of action and the absence of partial agonist activity make it a candidate for the treatment of advanced breast cancer in both pre- and postmenopausal women. Tamoxifen has been available for use over the past 25 years. However, its partial agonist activity has been associated with detrimental effects, particularly on the endometrium, and may be associated with the development of tamoxifen resistance. Other antioestrogen agents have previously been unable to demonstrate clinically relevant activity following the development of resistance to tamoxifen. In contrast, the unique mechanism of action of ICI 182,780 results in significant clinical activity in patients failing on tamoxifen therapy. Indeed, phase III clinical trials have demonstrated that ICI 182,780 is at least as effective as the aromatase inhibitor anastrozole in the treatment of postmenopausal patients with advanced disease who have progressed during threatment with prior enocrine therapy. As such, ICI 182,780 will provide a valuable addition to the armamentarium for the treatment of advanced breast cancer.
Chicken Protamine Genes Are Intronless (1989)

A positive cosmid clone obtained from a pwe15-rooster DNA library using a chicken protamine cDNA probe reveals the complete sequence of the two loci for the rooster protamine genes. The organization of these two loci within the cosmid clone matches that of genomic DNA. The copy number per haploid genome is two. The sequence for the rooster protamine predicted from the coding region shows differences from that previously determined at the protein level (Nakano, M., Tobita, T., and Ando, T. (1976) Int. J. Peptide Protein Res. 8, 565-578). A recent re-determination of the rooster protamine amino acid sequence (28 residues from the N terminus) matches that predicted from the genome rather than the sequence of Nakano et al. (1976). Both loci are intronless and the gene is extremely GC-rich (88% in the coding region). The 5' region of the gene contains a typical TATAAA box, several CG boxes, as well as other characteristic motifs. The 3' region of the gene contains the polyadenylation signal and several GT repeats of known Z-DNA forming potential. A correlation between the functional map of the gene and the tendency of the DNA to bend or to adopt the Z-conformation is presented and possible roles for these conformations in the transcription of this gene are discussed.
A New Approach to Modelling Water Flooding in a Polymer Electrolyte Fuel Cell (2014)

The distribution and migration of liquids in various layers of a PEFC is commonly modelled by the 3D flow equations. Given the fact these layers are very thin, there are major problems with such models, including heavy computational efforts and doubts in their applicability to the gas diffusion layer (GDL). Recently, a new approach for modelling multiphase flow through a stack of thin porous layers has been developed [Qin and Hassanizadeh, Int. J. Heat Mass Transfer 70 (2014) 693-708]. In this approach, which is called "reduced continua model", each layer is modelled as a 2D domain with governing equations formulated in terms of thickness-averaged properties. The mass exchange between layers is prescribed by a new constitutive equation. The aim of this paper is to illustrate the implementation of the reduced continua model and show its advantages in modelling liquid water flooding in the GDL and micro porous layer (MPL) of a PEFC. We find that, in comparison to the Richards model, the reduced continua model predicts quite similar water dynamics in the MPL, but a lower steady-state water saturation in the GDL, particularly under the channel area. We provide a quantitative indication of the enormous computational efficiency of the reduced continua model as compared to the Richards model. Finally, the sensitivity studies of major material parameters of the reduced continua model have been provided.
Improvement of IVF pregnancy rates through hormonal supplementation (1987)

info:eu-repo/semantics/nonPublished
Infection of C3HeB/FeJ mice with the docile strain of lymphocytic choriomeningitis virus induces autoantibodies specific for erythrocyte Band 3 (1997)

C3HeB/FeJ mice infected with the docile strain of lymphocytic choriomeningitis virus (LCMV-d) develop a persistent infection with a transient haemolytic anaemia. Immunoglobulin can be eluted from the red blood cells (RBC) of these mice but it cannot be detected on the RBC by a conventional antiglobulin test. The present study demonstrates that RBC from such mice bear erythrocyte autoantibodies which are predominantly of the IgG2a subclass, with lower levels of autoantibodies of the IgG1, IgG2b and IgG3 subclasses. To identify the target antigen the autoantibodies were eluted from the RBC of LCMV-infected mice. The eluted autoantibody bound to intact normal RBC and precipitated a 105000 MW component that corresponds to murine Band 3 protein. A monoclonal antibody derived from mice infected with LCMV-d also precipitated mouse Band 3, and reacted specifically by enzyme-linked immunosorbent assay against a purified preparation of Band 3. This study has shown that in C3H mice infected with LCMV-d which develop autoimmune haemolytic anaemia, the target autoantigen is erythrocyte membrane Band 3.
Evaluation of Yield Strength Taking Account of Particle Size-distribution in Particle Dispersion Strengthened Ferritic Steel (2005)

Yield strength of particle dispersion strengthened ferritic steel is discussed in consideration of the size-distribution of particles in some imaginary models with different type of size-distribution and real materials of an Fe-C alloy and Fe-oxide alloys. Estimation of the mean particle spacing (λ) using the models has revealed that λ strongly depends on the type of size-distribution: ideal distribution, nominal distribution and log-nominal distribution, and that the influence of size-distribution on λ becomes more significant with increasing size and volume fraction of particles. This means that the size-distribution has to be considered for the correct estimation of the increment in yield strength (Δσ) depending on particle dispersion strengthening, especially in high strengthened materials. The Δσ measured for the real materials was found to be proportional to λ-1 of the kind of particles by making an appropriate correction of the size-distribution of particles. Consequently, the increment of yield strength due to particle dispersion strengthening was described as Δσ [MPa]=64/λ [μm] in the iron-base ferritic alloys.
Modified Yukmijihwangtang Suppresses the Production of Proinflammatory Cytokines in the Intravesical Hydrochloric Acid-Induced Cystitis Rat Model via the NF-κB Pathway (2012)

Yukmijihwangtang (YM), a boiled extract of medicinal plants, has been prescribed for patients with kidney dysfunction in Korea; however, the mechanism underlying its therapeutic effects has not been fully elucidated. This study was conducted to evaluate the beneficial effects on bladder function by using modified YM (M-YM), which included Ulmi radicis cortex in addition to the six traditional medicinal plants in YM. Bladder irritation of the rats was caused by intravesical instillation of HCl. The animals were divided into six groups: sham group, cystitis-injury group with no treatment, cystitis-injury group with prednisolone treatment (5 mg/kg), and cystitis-injury with M-YM treatment (100, 200 or 500 mg/kg groups). Whole bladders were collected at day eight after injury. Samples were analyzed by histological and immunological examinations. An in vitro study was performed to determine whether M-YM extracts inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production and IκB phosphorylation in a human uroepithelial cell line of T24 cells. Administration of M-YM notably improved bladder histological changes, and suppressed IL-6/TNF α production and IκB phosphorylation in a rat model of chronic cystitis. M-YM also inhibited LPS-induced NO production and IκB phosphorylation in T24 cells. This study suggests that administration of M-YM might be an applicable therapeutic traditional medicine for the treatment of interstitial cystitis.