gebhart/patrepeval huggingface dataset:
Laser-assisted decay spectroscopy for the ground states of Au180,182 (2020)

A study of the ground states of the laser-ionized and mass-separated odd-odd isotopes $^{180,182}\mathrm{Au}$ was performed using the Resonance Ionization Laser Ion Source, Windmill detection setup and ISOLTRAP Multi-Reflection Time-of-Flight Mass Spectrometer at ISOLDE, CERN. A complex fine-structure $\ensuremath{\alpha}$-decay pattern of $^{180}\mathrm{Au}$ was deduced, providing insight into the low-lying levels in the daughter nucleus $^{176}\mathrm{Ir}$. An $\ensuremath{\alpha}$-decay branching ratio of ${b}_{\ensuremath{\alpha}}(^{180}\mathrm{Au})=0.58(10)%$ and a half-life of ${T}_{1/2}\phantom{\rule{0.16em}{0ex}}=\phantom{\rule{0.16em}{0ex}}7.2(5)$ s have also been derived, allowing for the calculation of the reduced $\ensuremath{\alpha}$-decay widths and determining the degree of hindrance of respective $\ensuremath{\alpha}$-decay branches. From complementary first in-source laser spectroscopy measurements of the hyperfine structure in atomic transitions of $^{180,182}\mathrm{Au}$, the nuclear magnetic moments of $\ensuremath{\mu}(^{180}\mathrm{Au})=\ensuremath{-}0.83(9)\phantom{\rule{4pt}{0ex}}{\ensuremath{\mu}}_{N}$ and $\ensuremath{\mu}(^{182}\mathrm{Au})=1.66(9)\phantom{\rule{4pt}{0ex}}{\ensuremath{\mu}}_{N}$ were extracted with an inclusion of a correction for the hyperfine anomaly. Based on the observed hyperfine structure patterns, and on the comparison of the measured and calculated $\ensuremath{\mu}$ values, a preferred ground-state spin and parity ${I}^{\ensuremath{\pi}}(^{180}\mathrm{Au}^{\mathrm{gs}})=({1}^{+})$ is proposed, and the earlier assignment of ${I}^{\ensuremath{\pi}}(^{182}\mathrm{Au}^{\mathrm{gs}})=({2}^{+})$ is confirmed. For $^{180}\mathrm{Au}$, the most probable proton-neutron Nilsson configuration of $\ensuremath{\pi}3/{2}^{\ensuremath{-}}[532]\ensuremath{\bigotimes}\ensuremath{\nu}5/{2}^{\ensuremath{-}}[512]$ suggests the same proton state as in the heavier deformed odd-odd nuclei $^{182,184}\mathrm{Au}$.
A randomized second line trial in patients with gemcitabine refractory advanced pancreatic cancer - CONKO 003 (2007)

4517 Objective: For nearly ten years gemcitabine (G) was standard first line therapy for patients (pts) with advanced pancreatic cancer (APC). There is no consensus about second line therapy after disease progression while receiving G, but 5-FU-based regimens are considered. Results about randomized second line studies in APC are very rare. Our phase II study (ASCO 2002) showed activity of the OFF (oxaliplatin/folinic Acid (FA)/5-fluorouracil (FU) [24h] ) regimen in 23 pts. To examine the impact and the side effects of oxaliplatin we initiated a multicenter phase III study to compare OFF and FF in pts with G refractory APC. Methods: Pts with CT/ MRT confirmed failure with G in first line therapy, Karnofsky Performance Status (KPS) &gt;60%, controlled pain, adequate hematological, renal and liver functions were eligible. Pts were stratified according to duration of first line therapy, KPS and tumor stage. We randomized pts to outpatient treatment with FF (FU 2g/m 2 (24h)/ FA 200 mg/m 2 (30min) on d1, d8, d15 and d22) or OFF (FF+Oxaliplatin 85mg/m 2 , d8, d22). In both arms the next cycle started on day 43. Pts were followed with regular staging every 3 months or at any signs of disease progression. Results: Until now we randomized 161 of 165 (planned) pts between 02/2004 and 01/2007. So we expect to present first results (side effects, progression free survival, overall survival) at the meeting. No significant financial relationships to disclose.
Measurement of high-order polarization mode dispersion (2000)

We demonstrate a new method to measure high-order polarization mode dispersion (PMD) using the Jones matrix exponential expansion. High-order PMD is characterized by measuring a series of characteristic matrices, which are convenient quantities for analyzing PMD effects in the time-domain. An experimental method is developed to estimate the validity range of the exponential expansion.
Basic Properties of Electron Multiplier Ion Detection and Pulse Counting Methods in Mass Spectrometry (1965)

The critical role played by first stage gain in shaping the output pulse height distribution and detection efficiency of an electron multiplier used as an ion detector is studied theoretically and experimentally. In a well-focused electron multiplier it is found that anode pulse height distributions observed for different ion species agree well with distributions calculated by using compound Poisson statistics. Models are developed to explain measurement bias in an electron multiplier which is used in either the dc or pulse counting modes and it is shown how these results can be applied to isotope ratio measurements. Design and operating characteristics are described for a 20 stage electron multiplier which was developed for high speed pulse counting and high detection efficiency. The surface of the first dynode is coated with a thin film of Al2O3 to provide a stable first stage yield of 7–9 secondary electrons/incident ion for monatomic alkali ions with 20 kV impact energy. The polyatomic ion Na2BO2+ yields about 16 secondary electrons/incident ion at 20 kV impact energy. Resolving time of the entire detector system is reduced to 10 nsec by using a specially designed solid state discriminator and pulse shaper. Also, a technique is described for the simultaneous detection and pulse counting of two ion beams.
Lanthanoid–Transition‐Metal Bonding in Bismetallocenes (2014)

Bismetallocenes [Cp2 LuReCp2 ] and [Cp*2 LaReCp2 ] (Cp=cyclopentadienyl; Cp*=pentamethylcyclopentadienyl) were prepared using different synthetic strategies. Salt metathesis-performed in aromatic hydrocarbons to avoid degradation pathways caused by THF-were identified as an attractive alternative to alkane elimination. Although alkane elimination is more attractive in the sense of its less elaborate workup, the rate of the reaction shows a strong dependence on the ionic radius of Ln(3+) (Ln=lanthanide) within a given ligand set. Steric hindrance can cause a dramatic decrease in the reaction rate of alkane elimination. In this case, salt metathesis should be considered the better alternative. Covalent bonding interactions between the Ln and transition-metal (TM) cations has been quantified on the basis of the delocalization index. Its magnitude lies within the range characteristic for bonds between transition metals. Secondary interactions were identified between carbon atoms of the Cp ligand of the transition metal and the Ln cation. Model calculations clearly indicated that the size of these interactions depends on the capability of the TM atom to act as an electron donor (i.e., a Lewis base). The consequences can even be derived from structural details. The observed clear dependency of the LuRu and interfragment LuC bonding on the THF coordination of the Lu atom points to a tunable Lewis acidity at the Ln site, which provides a method of significantly influencing the structure and the interfragment bonding.
Synthesis of some erbium(III) chelates and characterization of their NIR emission properties for use in organic near infrared optical amplification waveguides (2005)

Recent years have seen considerable interest in the possibility of using rare earth chelates as emissive materials in organic media. Lanthanides luminescence is quite interesting in applications requiring high spectral purity (for example in OLEDs), or infra red luminescence, in active optical waveguides for telecommunications. The use of organic optical amplification modules is attractive for their ease of fabrication, and therefore their potential low cost, but the high losses at NIR wavelength and the limitation of the emission lifetime due to the quenching effect of the organic matrix greatly limits their performances. However, rare earth chelates offer the possibility to reduce by several orders of magnitude the pump power needed for population inversion, using the absorption of the organic ligand followed by an energy transfer to the rare earth ion. By choosing a ligand with a high molecular absorption, it should then be possible to balance the short emission lifetime and hence to obtain optical amplification. We report on the synthesis and characterisation of the optical near infrared properties of an erbium phthalocyanine. The complex shows very high absorption in the 670nm region, is highly soluble and shows minimum concentration quenching effect. The red absorption could allow the use of standard laser diode as pump source in a planar polymer amplifier device.
Study of Förster Resonance Energy Transfer to Lipid Domain Markers Ascertains Partitioning of Semisynthetic Lipidated N-Ras in Lipid Raft Nanodomains (2017)

Cellular membranes are heterogeneous planar lipid bilayers displaying lateral phase separation with the nanometer-scale liquid-ordered phase (also known as "lipid rafts") surrounded by the liquid-disordered phase. Many membrane-associated proteins were found to permanently integrate into the lipid rafts, which is critical for their biological function. Isoforms H and N of Ras GTPase possess a unique ability to switch their lipid domain preference depending on the type of bound guanine nucleotide (GDP or GTP). This behavior, however, has never been demonstrated in vitro in model bilayers with recombinant proteins and therefore has been attributed to the action of binding of Ras to other proteins at the membrane surface. In this paper, we report the observation of the nucleotide-dependent switch of lipid domain preferences of the semisynthetic lipidated N-Ras in lipid raft vesicles in the absence of additional proteins. To detect segregation of Ras molecules in raft and disordered lipid domains, we measured Förster resonance energy transfer between the donor fluorophore, mant, attached to the protein-bound guanine nucleotides, and the acceptor, rhodamine-conjugated lipid, localized into the liquid-disordered domains. Herein, we established that N-Ras preferentially populated raft domains when bound to mant-GDP, while losing its preference for rafts when it was associated with a GTP mimic, mant-GppNHp. At the same time, the isolated lipidated C-terminal peptide of N-Ras was found to be localized outside of the liquid-ordered rafts, most likely in the bulk-disordered lipid. Substitution of the N-terminal G domain of N-Ras with a homologous G domain of H-Ras disrupted the nucleotide-dependent lipid domain switch.
The visual acts model for automated camera placement: further results and analysis (2003)

The visual acts theory aims to provide intelligent assistance for camera viewpoint selection during teleoperation. It combines a top-down model to partition a task into a sequence of operations and a bottom up component that monitors the operator in order to select task-relevant camera viewpoints in a timely manner for the operator. In a previous paper the authors (2001) presented results showing that visual acts does indeed provide a camera view of sufficient quality to allow an operator to complete a task. In this paper we present further results that bear on the performance of visual acts. The results provide further insights into the provision of operator controls for teleoperation and the role of additional cues, such as shadows, in task completion.
Breakdowns and the formation of microdischarge channels in surface barrier discharges (2008)

The dynamics of the space-time evolution of a creeping (surface) barrier discharge in pure oxygen at atmospheric pressure was studied by numerical simulation. The breakdown through a gas gap was found to end by the formation of a cathode layer. The distribution of parameters in this layer was close to that in the “normal” cathode layer. The cathode layer, which was a source of electrons, sustained the formation of a microdischarge channel above a dielectric. Microdischarge channel elongation over a dielectric was shown to be effected by a streamer formed in the head of the channel and to be accompanied by charge fall-out onto the surface of the dielectric barrier. This noticeably decreased the mean electric field strength in the channel and the intensity of discharge processes and eventually caused their cessation.
Remote meta‐CH Olefination of Phenylacetic Acids Directed by a Versatile U‐Shaped Template (2014)

meta-C-H olefination of phenylacetic acid derivatives has been achieved using a commercially available nitrile-containing template. The identification of N-formyl-protected glycine as the ligand (Formyl-Gly-OH) was crucial for the development of this reaction. Versatility of the template approach in accommodating macrocyclopalladation processes with different ring sizes is demonstrated.
Study on the Source Parameters of the Barkam Earthquake Sequence (2006)

用由 Barkam 车站记录的数字波浪数据，为有在 Barkam 区域的 ML2.5 5.0 的 93 地震的来源参数被决定由光谱分析。在地震时刻瞬间和本地规模 ML 之间有高关联的来源参数表演的初步的分析，它是 lg10 M0 = 0.92ML + 10.24，关联系数 R 是 0.86；在压力落下和本地规模 ML 之间的关系的调查显示压力落下似乎独立于 ML。
The Linear Predictor for a Single Time Series (1949)

This chapter contains sections titled: 2.01 Formulation of the Problem of the Linear Predictor, 2.02 The Minimization Problem, 2.03 The Factorization Problem, 2.04 The Predictor Formula, 2.1 Examples of Prediction, 2.2 A Limiting Example of Prediction, 2.3 The Prediction of Functions Whose Derivatives Possess Auto-correlation Coefficients, 2.4 Spectrum Lines and Non-absolutely Continuous Spectra, 2.5 Prediction by the Linear Combination of Given Operators, 2.6 The Linear Predictor for a Discrete Time Series
Shooter localization and weapon classification with soldier-wearable networked sensors (2007)

The paper presents a wireless sensor network-based mobilecountersniper system. A sensor node consists of a helmetmountedmicrophone array, a COTS MICAz mote for internodecommunication and a custom sensorboard that implementsthe acoustic detection and Time of Arrival (ToA) estimationalgorithms on an FPGA. A 3-axis compass providesself orientation and Bluetooth is used for communicationwith the soldier's PDA running the data fusion and the userinterface. The heterogeneous sensor fusion algorithm canwork with data from a single sensor or it can fuse ToA orAngle of Arrival (AoA) observations of muzzle blasts andballistic shockwaves from multiple sensors. The system estimatesthe trajectory, the range, the caliber and the weapontype. The paper presents the system design and the resultsfrom an independent evaluation at the US Army AberdeenTest Center. The system performance is characterized by 1-degree trajectory precision and over 95% caliber estimationaccuracy for all shots, and close to 100% weapon estimationaccuracy for 4 out of 6 guns tested.
Membrane Inlet Mass Spectrometer for Rapid High-Precision Determination of N2, O2, and Ar in Environmental Water Samples (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMembrane Inlet Mass Spectrometer for Rapid High-Precision Determination of N2, O2, and Ar in Environmental Water SamplesTodd M. Kana, Christina. Darkangelo, M. Duane. Hunt, James B. Oldham, George E. Bennett, and Jeffrey C. CornwellCite this: Anal. Chem. 1994, 66, 23, 4166–4170Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/ac00095a009https://doi.org/10.1021/ac00095a009research-articleACS PublicationsRequest reuse permissionsArticle Views2423Altmetric-Citations568LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A First Order Sufficient Condition for Optimality in Nonsmooth Optimization (1989)

Abstract We derive a simple sufficient condition for a point a ∈ S ⊂ X be a local minimum of f: X → R on S . This condition is of the first order in its nature and takes into account the derivative (or some generalization of it) in a neighborhood of a. Applications like a sufficient condition for ( a, b )∈ S × T ⊂ X × Y be a saddle‐point of a bivariate function f: X × Y ⊂ R are also proposed.
Elastic-Wave Velocities in Jurassic-Age Oceanic Crust from Analysis of Sonic Full Waveform Logs in Hole 801C (1995)

Using sonic full waveforms recorded by a borehole compensated logging sonde during Leg 144, we determined P-and S-wave velocities in the uppermost basement interval (from 480 to -560 mbsf) of Jurassic crust penetrated by Hole 801C. The basement consists of three principal units: an uppermost ~157-Ma alkali basalt, erupted off-axis; a zone of hydrothermal deposits; and a section of ~167-Ma mid-ocean ridge tholeiites. In the alkali basalts, V p ranges from 4.8 to 5.1 and V^ ranges from 2.4 to 2.6 km/s, yielding V p /V s between 1.9 and 2.0. In the tholeiites, V p ranges from 5.2 to 6.2 and V^ ranges from 2.8 to 3.4 km/s, yielding V p /V s between 1.75 and 1.85. We were unable to confirm the extremely low f-wave velocities reported previously within sections of the hydrothermal interval. Within the basalts, low-velocity zones mark the boundaries between individual lithostratigraphic units. A comparison of sonic log velocities within crusts of a wide variety of ages with laboratory-determined ultrasonic velocities reveals that (1) lower average in situ velocities in young crust are a consequence of the presence of macroscopic voids and fractures and of systematic sampling bias; (2) these effects are minimized in old crust by the infilling of fractures and voids and by a decrease in sampling bias in older, more altered basalts; (3) velocities within pillows and interflow zones never reach values equivalent to those in massive units; and (4) alteration of the basalt matrix can significantly reduce its velocity. Velocities, therefore, are controlled by the relative percentages of pillows and flows, the progressive increase in velocity within the pillows resulting from infilling, and an alteration-dependent decrease in velocities within the basalt matrix with increasing crustal age.
Thermally and UV Stable Natural Dyes with Potential Use in Efficient Photoelectrochemical Devices (2015)

&lt;p&gt;Energy alternatives have been one of the most important research focal areas of the last decade due to the imminent lack of fossil fuels. This motivation has allowed the evolution of the materials science field in areas such as electrochemistry, where high availability, low cost and negligible environmental impact are the desired principal qualities. For this reason, as an example of a photoelectrochemical device, we have proposed the use of natural dyes from 37 agro-industrial wastes in dye-sensitized solar cells. We obtained dyes from red cabbage, radish and roselle wastes with a good stability for eight hours with a constant dose of UV radiation at 60 &deg;C. In these, a strong copigmentation effect was observed at 90 &deg;C in a few hours. Besides which, an increase in the absorption spectra close to 200% was reached with the media extraction proposed. Additionally, the fabricated solar devices reached efficiencies between 0.5% and 1.7%.&lt;/p&gt;
Weft, Warp, and Weave: The Intricate Tapestry of Calcium Channels Regulating T Lymphocyte Function (2013)

Calcium (Ca(2+)) is a universal second messenger important for T lymphocyte homeostasis, activation, proliferation, differentiation, and apoptosis. The events surrounding Ca(2+) mobilization in lymphocytes are tightly regulated and involve the coordination of diverse ion channels, membrane receptors, and signaling molecules. A mechanism termed store-operated Ca(2+) entry (SOCE), causes depletion of endoplasmic reticulum (ER) Ca(2+) stores following T cell receptor (TCR) engagement and triggers a sustained influx of extracellular Ca(2+) through Ca(2+) release-activated Ca(2+) (CRAC) channels in the plasma membrane. The ER Ca(2+) sensing molecule, stromal interaction molecule 1 (STIM1), and a pore-forming plasma membrane protein, ORAI1, have been identified as important mediators of SOCE. Here, we review the role of several additional families of Ca(2+) channels expressed on the plasma membrane of T cells that likely contribute to Ca(2+) influx following TCR engagement, particularly highlighting an important role for voltage-dependent Ca(2+) channels (CaV) in T lymphocyte biology.
Risk of tuberculosis following HIV seroconversion in high-income countries (2012)

TB risk increases with duration of HIV infection in the absence of cART. Following cART initiation, TB incidence rates were lower than levels immediately following seroconversion. Implementation of current recommendations to prevent TB in early HIV infection could be beneficial.
Supplementary Table and Figures from Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth <i>In Vitro</i> and <i>In Vivo</i> (2023)

&lt;p&gt;Supplementary Table and Figures - PDF file 184K, Suppl Table S1: Immunohistochemical analysis indicates correlation between pAKT(Ser473),pERK1/2(Thr202/Tyr204) and pS6(Ser235/236) in primary tumours Fig S1. High level expression of p110delta in two of four ARMS cell lines. Fig S2. PIK3CA KD does not induce cell cycle arrest or apoptosis in the growth inhibited RMS cells. Fig S3. Downregulation of PTEN expression appears to be associated with delayed inhibition of AKT phosphorylation in RH30 cells following p110� KD. Fig S4 Increased sensitivity of the RMS-1 PIK3CA KD line to TGX221, and of the RMS-1, RD and RMS-YM KD lines to ZSTK474. Fig S5 Equivalent changes in the biomarkers of MAPK and PI3K activity at 6h in vivo, to those seen in vitro following acute dosing with AZD6244 and AZD8055 alone, and in combination, with recovery to control levels correlating with plasma and tumor clearance of both drugs. Fig S6 Tolerability study of twice daily dosing of 10mk/kg po AZD6244 and AZD8055 indicates reversible weight loss with combination treatment, while PK analysis of tail vein blood spots confirms drug-drug interactions. Fig S7 Dose-finding therapeutic study defines a once daily treatment schedule of AZD6244, 10mg/kg p.o., and AZD8055, 20mg/kg p.o., as well tolerated and active when given in combination&lt;/p&gt;
Application of carboxylic‐phospholanic mixed anhydrides to fragment coupling in peptide synthesis (1992)

The application of 1-oxo-1-chlorophospholane as a novel reagent for the in situ activation of peptide fragments for use in peptide bond forming reactions, either in liquid or solid phase, has been examined. 24.1 MHz 31P NMR spectroscopy has been employed to follow the formation, stability and reactivity of the intermediate phospholanic-carboxylic mixed anhydride.