gebhart/patrepeval huggingface dataset:
A 130mW 100MS/s pipelined ADC with 69dB SNDR enabled by digital harmonic distortion correction (2009)

A pipelined ADC is presented with 2 fully integrated digital background calibration techniques: harmonic distortion correction (HDC) to compensate for residue amplifier gain error and nonlinearity, and DAC noise cancellation (DNC) to compensate for DAC capacitor mismatches. It is the first IC implementation of HDC, and the results demonstrate that HDC and DNC together enable reductions in power dissipation relative to comparable conventional state-of-the-art pipelined ADCs.
All-aqueous multiphase microfluidics (2013)

Immiscible aqueous phases, formed by dissolving incompatible solutes in water, have been used in green chemical synthesis, molecular extraction and mimicking of cellular cytoplasm. Recently, a microfluidic approach has been introduced to generate all-aqueous emulsions and jets based on these immiscible aqueous phases; due to their biocompatibility, these all-aqueous structures have shown great promises as templates for fabricating biomaterials. The physico-chemical nature of interfaces between two immiscible aqueous phases leads to unique interfacial properties, such as an ultra-low interfacial tension. Strategies to manipulate components and direct their assembly at these interfaces needs to be explored. In this paper, we review progress on the topic over the past few years, with a focus on the fabrication and stabilization of all-aqueous structures in a multiphase microfluidic platform. We also discuss future efforts needed from the perspectives of fluidic physics, materials engineering, and biology for fulfilling potential applications ranging from materials fabrication to biomedical engineering.
A novel low cost fractal antenna structure for UWB applications (2015)

This study presents a new printed antenna designed by using the fractal geometry based on the association between rectangular and circular shapes to obtain a new form iterated three times with reduced size. The CPW line (Coplanar Waveguide) has been used as feed line technique. The operation frequency range of the proposed antenna is between 3.1 and 10.6 GHz which is the frequency band of UWB (Ultra wideband) released by FCC (Federal Communication Commission).
The Development of Data Acquisition and Remote Real-Time Display System for EAST NBI (2013)

The data acquisition and remote real-time display system for the neutral beam injectors (NBI) on experimental advanced superconducting tokamak (EAST) are described in this paper. Distributed computer systems including local data acquisition (DAQ) facility, remote data server (DS), real-time display terminal are adopted with Linux and Windows operating system. Experimental signals are gathered by DAQ device at local working field. On the one hand, these gathered data will be sent to DS which runs on remote server main control layer on EAST NBI control network for saving and processing; on the other hand, these data will be sent to real-time display terminal which runs on remote monitoring layer on EAST NBI for displaying and monitoring experimental signals real-timely. Another point needs to be mentioned is that the real-time display software can call back historical data from DS for querying. The software of data acquisition and DS are programmed by C language while the real-time display software is programmed by Labview flow chart. The hardware mainly includes DAQ cards, server, industrial personal computer and others auxiliary hardware. Now the system proved to be performed well through experiments on NBI testing bed.
Development Of A Pingpong Robot System Using 7 Degrees Of Freedom Direct Drive Arm (1987)

A pingpong robot system using a 7 degrees of freedom direct drive arm has been developed. This system is composed of a binocular camera for measuring the position and the speed of a pingpong ball, a pitching machine, a direct drive robot, and a controller with a multi-microcomputer system. Three important techniques have been developed here. First involves the fast ball position measurement technique using the binocular camera, which has two linear sensors located horizontally on the focal plane of each lens. Second is a technique for forecasting hitting position and time. Third, direct drive robot control technique with real time calculation of inverse kinematics. These techniques are essential to perform unstructured tasks with a robot in real time.
Prediction of Cell Type Specific Transcription Factor Binding Site Occupancy (2016)

We propose a. machine learning approach to predict the particular cell type where a given transcription factor can bind a DNA sequence. The learning models are trained on the DNA sequences provided from the publicly available ChIPseq experiments of the ENCODE project for 52 transcription factors across the GM12878, K562, HeLa, H1-hESC and HepG2 cell lines. Three different feature extraction methods are used based on k-mer representations, counts of known motifs, and a new model called the skip gram model, which has become very popular in the analysis of text. The logistic regression with ℓ1 penalty is used for the classification task. We find that predictors based on known motifs counts detect cell-type specific signatures better than a previously published method, with mean AUC improvement of 0.18 and can be used to identify t he interaction of transcription factors. Remarkably, the skip gram approach, which can be used without of any prior knowledge about transcription factor binding sit es, performs almost as well as the motif-based method. Overall, our family of predictors will be useful to both better predict cell-type specific TF occupancy and understand the mechanisms underlying this phenomenon.
Original and generic clopidogrel: A comparison of antiplatelet effects and active metabolite concentrations in patients without polymorphisms in the ABCB1 gene and the allele variants CYPC19*2 and *3 (2021)

In comparison with original clopidogrel, the use of its generic form does not affect the blood concentrations of the active metabolite or its antiplatelet effect.
Supplementary Figure 3 from Molecular Dissection of Hyperdiploid Multiple Myeloma by Gene Expression Profiling (2023)

Supplementary Figure 3 from Molecular Dissection of Hyperdiploid Multiple Myeloma by Gene Expression Profiling
Les hypoalphalipoprotéinémies sont-elles toujours un facteur de risque de l’athérosclérose ? (1997)

Les hypoalphalipoproteinemies sont-elles toujours un facteur de risque de l’atherosclerose ? L’incidence de l’insuffisance coronaire est en correlation inverse avec la concentration des lipoproteines de haute densite (HDL). Mais le role direct des HDL dans l’apparition et le developpement des lesions d’atherosclerose est hypothetique. L’effet biologique indeniable joue par les HDL dans le processus du retour du cholesterol des tissus peripheriques vers le foie est un argument en faveur du role protecteur direct des HDL. Cependant, l’absence d’atherosclerose chez certains sujets qui presentent une concentration tres faible en HDL due a des mutations du gene de l’apolipoproteine AI ou de celui de la LCAT (lecithin cholesterol acyl transferase) suggere que les HDL telles qu’elles apparaissent chez les sujets normaux ne sont pas indispensables pour empecher l’apparition de l’atherosclerose. Un catabolisme rapide des HDL ainsi qu’une synthese normale de l’apolipoproteine A1 sont frequemment trouves chez ces sujets. A l’inverse, une synthese diminuee ou nulle d’apolipoproteine AI est souvent responsable du developpement precoce de lesions d’atherosclerose. Le modele de la souris chez laquelle le gene de l’apolipoproteine AI ne s’exprime plus va a l’encontre de cette hypothese, puisque cette souris ne developpe pas d’atherosclerose. Cependant, le metabolisme des lipoproteines de la souris est tres different de celui de l’homme. Par ailleurs, chez l’homme, une hypoalphalipoproteinemie est frequemment concomitante d’autres anomalies metaboliques, augmentation des remnants de lipoproteines de tres basse densite, lipoproteines de basse densite de petite taille, elles-memes reputees atherogenes. Dans ce cas, la baisse des HDL pourrait n’apparaitre que comme le temoin d’anomalies responsables d’atherosclerose frequemment rencontrees au cours du syndrome metabolique. L’elucidation du role des HDL dans le developpement de l’atherosclerose est fondamental pour orienter les recherches therapeutiques.
ChemInform Abstract: Alkylation and Decarboxylation of Ethyl 2‐Fluoro‐3‐oxobutanoate as a Route to Functionalized α‐Fluoro‐ketones. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Design optimisation of self‐powered gate driver for ultra‐fast DC solid‐state circuit breakers using SiC JFETs (2017)

Solid‐state circuit breakers (SSCBs) inherently have excellent protection performance, thus they are popular for DC distribution protection. However, the safety and reliability of the SSCBs are limited by the rapid response ability of their own gate drivers. In this study, a self‐powered SSCB with a normally‐on silicon carbide (SiC) junction gate field‐effect transistor (JFET) is proposed as the solid‐state switch, whose gate drivers are optimised as well. First, both an optimised fault detection circuit and a designed forward–flyback DC/DC converter of the SSCB gate driver have been presented to achieve fast protection during the course of fault isolation. Then, the detailed analyses of the gate driver circuit parameters effect on protection speed are further investigated based on circuit theory and MATLAB calculation. In order to compare and analyse the dynamic responses of the SSCB with and without optimisation, the actual interruption tests of the fabricated SiC JFET circuit breaker prototype and the employed prototype 400 V DC distribution system have been carried out. The results show that the implementation approach is able to improve protection speed for the SSCBs within the order of a few microseconds.
Microscopic Behavior of Internet Congestion Control (2007)

The Internet research community has focused on the macroscopic behavior of Transmission Control Protocol (TCP) and overlooked its microscopic behavior for years. This thesis studies the microscopic behavior of TCP and its effects on performance. We go into the packet-level details of TCP control algorithms and explore the behavior in short time scales within one round-trip time. We find that the burstiness effects in such small time scales have significant impacts on both delay-based TCP and loss-based TCP. For delay-based TCP algorithms, the micro-burst leads to much faster queue convergence than what the traditional macroscopic models predict. With such fast queue convergence, some delay-based congestion control algorithms are much more stable in reality than in the analytical results from existing macroscopic models. This observation allows us to design more responsive yet stable algorithm which would otherwise be impossible. For loss-based TCP algorithms, the sub-RTT burstiness in TCP packet transmission process has significant impacts on the loss synchronization rate, an important parameter which affects the efficiency, fairness and convergence of loss-based TCP congestion control algorithms. Our findings explain several long-standing controversial problems and have inspired new algorithms that achieve better TCP performance.
Front Matter: Volume 8927 (2014)

This PDF file contains the front matter associated with SPIE Proceedings Volume 8927, including the Title Page, Copyright information, Table of Contents, Invited Panel Discussion, and Conference Committee listing.
An Organometallic Sandwich Lanthanide Single-Ion Magnet with an Unusual Multiple Relaxation Mechanism (2011)

A dysprosium(III) sandwich complex, [Dy(III)(COT″)(2)Li(THF)(DME)], was synthesized using 1,4-bis(trimethylsilyl)cyclooctatetraenyl dianion (COT″). The complex behaves as a single-ion magnet and demonstrates unusual multiple relaxation modes. The observed relaxation pathways strongly depend on the applied static dc fields.
Protein Extraction from Formalin-fixed, Paraffin-embedded Tissue Sections: Quality Evaluation by Mass Spectrometry (2006)

A satisfactory protocol of protein extraction has been established based on the heat-induced antigen retrieval (AR) technique widely applied in immunohistochemistry for archival formalin-fixed, paraffin-embedded (FFPE) tissue sections. Based on AR, an initial serial experiment to identify an optimal protocol of heat-induced protein extraction was carried out using FFPE mouse tissues. The optimal protocol for extraction of proteins was then performed on an archival FFPE tissue of human renal carcinoma. FFPE sections were boiled in a retrieval solution of Tris-HCl containing 2% SDS, followed by incubation. Fresh tissue taken from the same case of renal carcinoma was processed for extraction of proteins by a conventional method using radioimmunoprecipitation assay solution, to compare the efficiency of protein extraction from FFPE tissue sections with extraction from fresh tissue. As a control, further sections of the same FFPE sample were processed by the same procedure without heating treatment. Evaluation of the quality of protein extracted from FFPE tissue was done using gel electrophoresis and mass spectrometry, showing most identified proteins extracted from FFPE tissue sections were overlapped with those extracted from fresh tissue.
Efficient Ultraviolet Rotational Raman Lidar for Temperature Profiling of the Planetary Boundary Layer (2012)

An efficient rotational Raman scattering lidar using an ultraviolet-wavelength laser has been developed for temperature profile measurement of the planetary boundary layer in the lower troposphere. In this system, the high rejection of intense elastic Rayleigh and Mie backscattering was realized by a rotational Raman spectrometer using a diffraction grating and dual interference filters. Temperature measurement in thin cloud was demonstrated, and it was shown that the temperature profile obtained by lidar measurement is in good agreement with that obtained by radiosonde measurement. A statistical error of less than 1 K was obtained up to 2.5 km height in daytime measurement and up to 4.6 km height in nighttime measurement in clear air with an observation time of 16 min.
Energy Cube and Energy Magnets (2006)

Combining the easy to use characteristics of tangible interfaces with the peripheral representation of ambient displays, two prototype energy displays – Energy Cube and Energy Magnets – were designed to help people become aware of their home energy consumption patterns. This paper reports on the design and evaluation of those two displays.
Scaling properties of soft-core parallel spherocylinders near the crystal–smectic-phase transition (1993)

By carrying out constant-pressure molecular-dynamics simulations near the melting transition from crystal to smectic liquid crystal, we characterize the scaling properties of systems composed of soft-core parallel spherocylinders. Properties at the transition have a clear dependence on the length-to-width ratio of the cylinder. These scaling properties are explained by introducing the concept of the temperature dependence of the effective core of the spherocylinders. Utilizing these scaling properties, the equations of state of systems with different anisotropy can be scaled onto one another.
Front Cover: On the Mediated Electron Transfer of Immobilized Galactose Oxidase for Biotechnological Applications (Chem. Eur. J. 30/2022) (2022)

An enzymatic bioelectrode made up of galactose oxidase electrically wired with a redox polymer was used for the electrocatalytic oxidation of bio-renewable substrates with minimal influence from ambient O2. A practical example for the conversion of glycerol and 5-(hydroxymethyl)furfural in a circular flow-through setup is shown. The products were inspected to evaluate the possibility of substrate over-oxidation during enzymatic catalysis. More information can be found in the Research Article by W. Schuhmann, F. Conzuelo and co-workers (DOI: 10.1002/chem.202200868).
First-Principles Design and Simulations Promote the Development of Nonlinear Optical Crystals (2019)

ConspectusA hot topic in materials science is to search for nonlinear optical (NLO) crystals, which are indispensable in current laser technology, future optical information, and precision measurements. In the period of the 1980s and 1990s, the anionic group theory proposed by Prof. Chuangtian Chen has greatly promoted the inventions of BaB2O4 (BBO), LiB3O5 (LBO), and KBe2BO3F2 (KBBF) which are widely applied in the ultraviolet (UV) spectral region today. From the beginning of this century, the rapid development of laser science and technology urgently demands new NLO crystals for wider application ranges. However, commercial NLO crystals in deep-UV and mid-infrared (mid-IR) regions are scarce. The challenge arises from the stringent criteria at various wavelengths and inefficient exploration strategy. As such, more comprehensive and quantitative theoretical guidance is necessary to improve and supplement the NLO structure–property understandings. Benefiting from high-performance computing resources, first-principles design and simulations came into being, which is more applicable to the understanding of mid-IR NLO mechanism and suitable for the efficient design of new NLO structures for current needs. In the past decade, a complete set of computational research programs based on first-principles simulations have been developed, which have promoted the development of NLO crystals in the deep-UV and mid-IR regions, and guided the subsequent and further experimental explorations. Based on our developed first-principles materials design system, the discoveries of NLO materials have ranged from basic theoretical design to rapid-prototyping and final experimental synthesis.In this Account, we will concisely summarize our ab initio guided and forward-looking studies on NLO crystals, which are our original contributions to this field and can be consulted by other material fields. First, we will review the development of NLO crystals and the important features of NLO materials. Second, we will summarize the important role of computer-aided design in advancing the NLO material field and our developed NLO material design system based on the first-principles simulations. Third, we will introduce the first-principles design for new deep-UV NLO crystals using two novel design proposals, i.e., interlayer cationic replacement and intralayer anionic substitution. Meanwhile, we will illustrate the hierarchical molecular engineering optimizations for mid-IR NLO crystals by illustrating an extended mid-IR NLO family pedigree, from which many promising mid-IR NLO systems were predicted theoretically and confirmed experimentally. Finally, we will give an outlook to explore new functional NLO crystals guided by our first-principles design and simulations. We believe that the computer-assisted exploration for new functional NLO materials is useful for understanding structure–property relationships and can provide researchers with a new approach to cost-effective and data-driven materials design.
High Mobility Group A2 Potentiates Genotoxic Stress in Part through the Modulation of Basal and DNA Damage–Dependent Phosphatidylinositol 3-Kinase–Related Protein Kinase Activation (2005)

The high mobility group A2 (HMGA2) protein belongs to the architectural transcription factor HMGA family, playing a role in chromosomal organization and transcriptional regulation. We and others have previously reported that ectopic HMGA2 expression is associated with neoplastic transformation and anchorage-independent cell proliferation. Here, we reported a correlation between increased HMGA2 expression and enhanced chemosensitivity towards topoisomerase II inhibitor, doxorubicin, in breast cancer cells. Using cells exhibiting differential HMGA2 expression and small interfering RNA technique, we showed that HMGA2 expression modulates cellular response to the genotoxicity of DNA double-strand breaks. Notably, HMGA2 enhances doxorubicin-elicited cell cycle delay in sub-G1 and G2-M and augments cell cycle dysregulation on cotreatment of doxorubicin and caffeine. We further reported that HMGA2 induces a persistent Ser139 phosphorylation of histone 2A variant X, analogous to the activation by doxorubicin-mediated genotoxic stress. Moreover, this HMGA2-dependent enhancement of cytotoxicity is further extended to other double-strand breaks elicited by cisplatin and X-ray irradiation and is not restricted to one cell type. Together, we postulated that the enhanced cytotoxicity by double-strand breaks in HMGA2-expressing cells is mediated, at least in part, through the signaling pathway of which the physiologic function is to maintain genome integrity. These findings should contribute to a greater understanding of the role of HMGA2 in promoting tumorigenesis and conveying (chemo)sensitivity towards doxorubicin and other related double-strand breaks.
A Phase II Single Arm Pilot Study of the CHK1 Inhibitor Prexasertib (LY2606368) in BRCA Wild-Type, Advanced Triple-Negative Breast Cancer (2020)

Prexasertib monotherapy had modest clinical efficacy in BRCAwt TNBC. Further studies of prexasertib in combination with other agents are needed.
On Tracking Free Surfaces in Liquids (2005)

We consider a variational principle suitable for tracking boundaries of gas bubbles in liquids and its consequences. The principle is derived from a generalization of the Principle of Stationary Action applied to a Riemannian manifold of volume preserving flow maps. The dual variational principle for the markers tracking the free surfaces is induced by the Wasserstein-Kantorovich metric. This later variational principle provides means to compute the dynamics of free, implicit, surfaces without explicitly solving for the fields and quantities which define them. The presented theory suggests the following approximate evolution equation for the characteristic function of the gas, written in the Lagrangian frame of reference, ρG (∂ttχ(x, t)− λ∂tχ(x, t)) = div (χ(x, t) ((ρG − ρL)~g + α∇H(x, t))) , x ∈ S(∇χ), t > 0, where S(∇χ) represents the set of points on the gas-liquid interfaces, and H denotes the mean curvature of the interface. The constants α and λ denote the surface tension and Rayleigh’s friction dissipation constants, respectively. The density of the liquid and gas are denoted ρL and ρG. The gravitational force is denoted ~g. The regularized version of this equation is given, for some ǫ > 0, by ρG (∂ttsǫ(x, t)− λ∂tsǫ(x, t)) = div (