gebhart/patrepeval huggingface dataset:
Extremely large broadband emission of CdSe/CdS nanocrystals under high excitation (2023)

Single core/shell CdSe/CdS colloidal nanocrystals are usually used as efficient single photon sources working at room temperature, with a narrow spectrum of =30nm. For large shell, they evidence a strong resistance to high excitation and can withstand a few 106W/cm2,. Under high excitation their emission change dramatically, emission evolves non linearly with laser excitation power and the spectrum range can reach a few 100nm. In order to understand such a behavior, we use a statistical description of the electrons and holes population as fermi dirac distributions, followed by radiative recombination of excitons, which describes well experimental results.
Comparison of rigorous coupled-wave approach and finite element method for photovoltaic devices with periodically corrugated metallic backreflector (2014)

Optimal design of photovoltaic devices with a periodically corrugated metallic backreflector requires a rapid and reliable way to simulate the optical characteristics for wide ranges of wavelengths and angles of incidence. Two independent numerical techniques are needed for confidence in numerical results. We compared the rigorous coupled-wave approach (RCWA) and the finite element method (FEM), the former being fast and flexible, but the latter having predictable convergence even for discontinuous constitutive properties. Depending on the shape of the corrugation and the constitutive properties of the metal and dielectric materials making up the device, both techniques can exhibit slow convergence rates for p-polarized light. The chosen model problem in this paper is of this type. As rapid spatial variations of the fields are the underlying cause, suitable selective refinement of the FEM mesh can overcome this slow convergence. Therefore, it would be desirable to have a self-adaptive scheme for choosing the mesh in the FEM. This will slow down the algorithm but give a reliable way to check the RCWA results.
Iron Deposits in Periaqueductal Gray Matter Are Associated with Poor Response to OnabotulinumtoxinA in Chronic Migraine (2020)

Previous studies have reported increased brain deposits of iron in patients with chronic migraine (CM). This study aims to determine the relation between iron deposits and outcome after treatment with OnabotulinumtoxinA (OnabotA). Demographic and clinical data were collected for this study through a prospective cohort study including 62 CM patients treated with OnabotA in the Hospital Clínico Universitario de Santiago de Compostela (Spain). Demographic and clinical variables were registered. Selected biomarkers in plasma during interictal periods (calcitonin gene-related peptide (CGRP) and pentraxin-3 (PTX3)) and neuroimaging changes (iron deposits in the red nucleus (RN), substantia nigra (SN), globus pallidus (GP), and periaqueductal gray matter (PAG), and white matter lesions (WML)) were determined. Subjects were classified in responders (≥50% reduction in headache days) or non-responders (<50%). Responders to treatment were younger (mean age difference = 12.2; 95% confidence interval (CI): 5.4-18.9, <i>p</i> = 0.001), showed higher serum levels of CGRP (≥50 ng/mL) and PTX3 (≥1000 pg/mL) and smaller iron deposits in the GP and PAG (mean difference = 805.0; 95% CI: 37.9-1572.1 μL, <i>p</i> = 0.040 and mean difference = 69.8; 95% CI: 31.0-108.6 μL, <i>p</i> = 0.008; respectively). Differences in PAG iron deposits remained significant after adjusting for age (mean difference = 65.7; 95% CI: 22.8-108.6 μL, <i>p</i> = 0.003) and were associated with poor response to OnabotA after adjustment for clinical and biochemical variables (odds ratio (OR) = 0.963; 95% CI: 0.927-0.997, <i>p</i> = 0.041). We conclude that larger PAG iron deposits are associated with poor response to OnabotA in CM.
Impact of aqueous micellar media on biocatalytic transformations involving transaminase (ATA); applications to chemoenzymatic catalysis (2022)

Surfactant-enabled asymmetric ATA-catalyzed reductive aminations in aqueous buffered media are described, representative of the enhanced levels of conversion made possible by the presence of a nonionic surfactant in the water, thereby enabling 1-pot chemoenzymatic catalysis.
Sending messages to mobile users in disconnected ad-hoc wireless networks (2000)

An ad-hoc network is formed by a group of mobile hosts upon a wireless network interface. Previous research in this area has concentrated on routing algorithms which are designed for fully connected networks. The usual way to deal with a disconnected ad-hoc network is to let the mobile computer wait for network reconnection passively, which may lead to unacceptable transmission delays. In this paper, we propose an approach that guarantees message transmission in minimal time. In this approach, mobile hosts actively modify their trajectories to transmit messages. We develop algorithms that minimize the trajectory modifications under two different assumptions: (a) the movements of all the nodes in the system are known and (b) the movements of the hosts in the system are not known.
Turning of New Biomaterials (2014)

Abstract The article deals with determination of the fundamental characteristics of machining new technology for the production of biomaterials implants turning, using a removable cutting plates of cemented carbide surface modified coating TiAlN. Experimental determination of the size of components includes cutting forces in turning process, depending on the cutting parameters and cutting material used and monitor the formation and shaping chips.
Hybrid conditional planning for robotic applications (2020)

Robots who have partial observability of and incomplete knowledge about their environments may have to consider contingencies while planning, and thus necessitate cognitive abilities beyond classical planning. Moreover, during planning, they need to consider continuous feasibility checks for executability of the plans in the real world. Conditional planning is concerned with reaching goals from an initial state, in the presence of incomplete knowledge and partial observability, by considering all contingencies and by utilizing sensing actions to gather relevant knowledge when needed. A conditional plan is essentially a tree of actions where each branch of the tree represents a possible execution of actuation actions and sensing actions to reach a goal state. Hybrid conditional planning extends conditional planning by integrating feasibility checks into executability conditions of actions. We introduce a parallel offline algorithm, called HCPlan, for computing hybrid conditional plans. HCPlan relies on modeling deterministic effects of actuation actions and non-deterministic effects of sensing actions in the causality-based action language [Formula: see text]. Branches of a hybrid conditional plan are computed in parallel using a SAT solver, where continuous feasibility checks are performed as needed. We develop a comprehensive benchmark suite and introduce new evaluation metrics for hybrid conditional planning. We evaluate HCPlan with extensive experiments in terms of computational efficiency and plan quality. We perform experiments to compare HCPlan with other related conditional planners and approaches to deal with contingencies due to incomplete knowledge. We further demonstrate the applicability and usefulness of HCPlan in service robotics applications, through dynamic simulations and physical implementations.
Ein neues Virus ohne Speziesbarriere? Rustrela-Virus-assoziierte Meningoenzephalitis bei diversen Säugetierspezies (2022)

Einleitung Retrospektive Untersuchungen an Gehirnproben von Zootieren mit Meningoenzephalitiden unklarer Genese identifizierten Rubellavirus-ähnliche Sequenzen. Der Erstbeschreibung des Rustrela Virus (RusV) bei einem Hausesel, einem Bennett-Känguru, einem Wasserschwein und Gelbhalsmäusen folgten weitere Fälle bei einem Fischotter und einem Nasenbären.
ChemInform Abstract: POLYCYCLIC THIOPHENES FROM THE DIRECT INSERTION OF HETEROSULFUR BRIDGES INTO VINYLARENES, BIARYLS, AND ANGULARLY CONDENSED ARENES (1979)

Abstract Die Darstellung von Thiophenen und kondensierten Thiophenen (II), (IV), (VI) und (VIII) aus Olefinen (I), Vinylaromaten (III), Biarylen (V) oder angular kondensierten Aromaten wie Phenanthren (VII) durch Umsetzung mit Schwefelwasserstoff an heterogenen Katalysatoren bei Temperaturen von 450 ‐ 630°C wird beschrieben.
Methodology for accurate multi-spectral signature measurement (2008)

Transient multi-spectral signatures have become a basis for the development of IRST (IR Search and Track) and automatic target acquisition systems. Multi-spectral signatures must be measured in absolute physical system-independent units in order to be valid for use in system design. The required data comprise a temporal profile of the radiant intensity (or radiance) emitted by the target at the target plane in the required spectral bands. The methodology for converting electronic output signal from a multi spectral radiometer - volts - into the radiant intensity of the object is a complex procedure. In this procedure the following parameters have to be taken into account: the nature of the measured target (gray body or molecular emission spectra), the spectral filter, the detector responsivity, the frequency response and rise time and all ambient parameters such as atmospheric attenuation and solar radiance. Avoiding the correct analysis procedure, leads to erroneous data which may mislead users of multi-spectral signatures. This paper describes the appropriate methodology for multi-spectral signature measurement, analysis and factors that influence the accuracy of the resultant data.
Macrophage infiltration in the skin of patients with systemic sclerosis. (1992)

We stained skin specimens from 31 patients with systemic sclerosis with monoclonal antibodies to macrophages and T lymphocytes to characterize the cellular infiltrates. Not only T lymphocytes but macrophages were also identified, and macrophages were observed between collagen bundles as well as around skin adnexa and vessels. In addition, the ratio of macrophages to T lymphocytes was high, particularly in severely affected skin. There was no close relationship with disease duration. Our results suggest that cutaneous macrophages always play a role in scleroderma.
A Transient Cytotoxic Host Response to the Rous Sarcoma Virus-Induced Transplantation Antigen (1970)

This report is concerned with the time-relationship of cell-mediated immune reactions by hosts with expanding transplanted solid tumors. Inoculation of 106 serially passaged tumor cells elicited peak lymphocyte cytotoxic responses between 16 and 21 days followed by a state of immunological “paralysis.” Rats which were inoculated with 106 tumor cells which had been passaged four additional times in tissue culture gave lymphocytes with peak cytotoxic effects at 9 days after implantation and “paralysis” by 16 days. A stimulatory effect over and above the normal “feeder” effect by unsensitized lymphoid cells was noted when “paralyzed” cells were overlayed on the target cells. This “paralysis” could not be attributed to a general state of debilitation in the tumor-bearing hosts.
AAPG Memoir 67: Seals, Traps, and the Petroleum System. Chapter 15: A Pore-Pressure Limit in Overpressured South Texas Oil and Gas Fields (1997)

One way to simplify the characterization of pore pressure, Pp, in deep, overpressured basins is to divide oil and gas fields into stratified zones, based on average pressure-depth trends that are approximately linear. With this approximation, each zone is assigned a constant pressure-depth gradient. In the shallow portion of South Texas oil and gas fields (i.e., zone one), Pp has a hydrostatic gradient, whereas in the uppermost overpressured portions of these fields (i.e., zones two and three), Ppis characterized by gradients that exceed the lithostatic trend of 1 psi/ft (22.6 MPa/km) (Leftwich and Engelder, 1995). At greater depth (i.e., zone four), Pp increases along a gradient of about 0.9 psi/ft (20.3 MPa/km). The transition between zones three and four defines the depth at which Pp reaches a limit that is 85%-90% of the lithostatic (i.e., vertical) stress. Because a Pp gradient of ~0.9 psi/ft (20.3 MPa/km) is maintained throughout pressure zone FOUR in several South Texas fields, the Pp limit is a regional phenomenon. Two conditions leading to a Pp limit involve a cyclic leakage of pore fluid through zone FOUR. In both cases, leakage is governed by a balance between Pp and the minimum horizontal total stress, Sh. One condition favors leakage of pore fluid through zone FOUR upon the opening of existing joints or the propagation of new joints by natural hydraulic fracturing. The other condition favors leakage along faults following refracturing during slip events. The difference between these conditions is that leakage through joints can regulate Pp at a constant value through repeated cycles, whereas leakage by fault slip leads to an ever-increasing Pp as Sh increases through repeated cycles.
Boundary detection with a road model for occupancy grids in the curvilinear coordinate system using a downward-looking lidar sensor (2015)

Many studies using a laser scanner have been conducted in order to study the environment of vehicles in real time. The method to find the driving area using a two-dimensional lidar sensor is divided into a forward-looking lidar sensor and a downward-looking lidar sensor based on the installation method. A downward-looking lidar sensor looks at the ground, enabling it to recognize kerbs and ditches which are lower than the installation position of the sensor. However, a downward-looking lidar sensor requires pre-processing to find the road boundary. The existing sensor models cannot generate an occupancy grid map without support, as the driving area recognized through a downward-looking lidar sensor forms a circular sector shape from the sensor installation position to the road boundary. This paper proposes a road sensor model that is capable of modelling an occupancy grid. We also propose a method to generate an occupancy grid map more suitable for autonomous vehicles by presenting the occupancy grid map in curvilinear space. The proposed method was validated by an experiment at Hanyang University campus and the quantitative results obtained from that experiment. We also compared this method with three conventional sensor model methods. The experimental results show that our method performs better than the conventional methods do in terms of both visual qualities and metric qualities.
Effect of Obesity on the Prognostic Impact of Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction (2017)

AF had a negative impact on clinical outcome in non-obese patients with HFpEF.
Dosimetry of the Amersham 6711 OncoseedTMusing PRESAGETMand optical CT (2006)

To investigate the feasibility of solid polymer dosimetry as an accurate 3-D dose verification applied to prostatic brachytherapy, the model 6711 Oncoseed TM was selected for a pilot study comparing experimental methods and Monte Carlo simulations. This study is presented as a typical case study of what can be achieved using solid polymer dosimetry. © 2006 IOP Publishing Ltd.
Review of Hepatitis B Therapeutics (2010)

Currently, there are 7 approved therapies for chronic hepatitis B virus (HBV) infection, an increase from just 3 agents 5 years ago. This review will focus on the pharmacology, potency, and adverse events associated with immunomodulatory agents and nucleos(t)ide analogues, with an emphasis on targets of therapy within the HBV life cycle. We will also offer guidelines for the use of available anti-HBV agents and review the emerging challenges in hepatitis B management, including HBV drug resistance, its management, and the potential role of combination therapy.
Transparent 2-D markers on an LCD tabletop system (2009)

Tabletop systems are currently being focused on and many applications using these systems are being developed. In such tabletop systems, how to recognize real objects on the table is an essential and important issue. In existing tabletop systems, 2-D markers have been often used. However, their black-and-white pattern, which means nothing to humans, spoils the appearance of the object. We developed transparent markers on a liquid crystal display (LCD) tabletop system by using the polarization features of the LCD and optical lms. In particular, through experiments with various kinds of optical films, we found that two halfwave plates make the markers rotation invariant. By using the transparent markers, tangible transparent Magic Lenses(TM) applications were developed.
Intrinsic osteoinductivity of PCL‐DA/PLLA semi‐IPN shape memory polymer scaffolds (2021)

Engineering osteoinductive, self-fitting scaffolds offers a potential treatment modality to repair irregularly shaped craniomaxillofacial bone defects. Recently, we innovated on osteoinductive poly(ε-caprolactone)-diacrylate (PCL-DA) shape memory polymers (SMPs) to incorporate poly-L-lactic acid (PLLA) into the PCL-DA network, forming a semi-interpenetrating network (semi-IPN). Scaffolds formed from these PCL-DA/PLLA semi-IPNs display stiffnesses within the range of trabecular bone and accelerated degradation relative to scaffolds formed from slowly degrading PCL-DA SMPs. Herein, we demonstrate for the first time that PCL-DA/PLLA semi-IPN SMP scaffolds show increased intrinsic osteoinductivity relative to PCL-DA. We also confirm that application of a bioinspired polydopamine (PD) coating further improves the osteoinductive capacity of these PCL-DA/PLLA semi-IPN SMPs. In the absence of osteogenic supplements, protein level assessment of human mesenchymal stem cells (h-MSCs) cultured in PCL-DA/PLLA scaffolds revealed an increase in expression of osteogenic markers osterix, bone morphogenetic protein-4 (BMP-4), and collagen 1 alpha 1 (COL1A1), relative to PCL-DA scaffolds and osteogenic medium controls. Likewise, the expression of runt-related transcription factor 2 (RUNX2) and BMP-4 was elevated in the presence of PD-coating. In contrast, the chondrogenic and adipogenic responses associated with the scaffolds matched or were reduced relative to osteogenic medium controls, indicating that the scaffolds display intrinsic osteoinductivity.
Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice (2018)

Graft-versus-host disease (GVHD) remains one of the major complications after allogeneic bone marrow transplantation (allo-BMT). Sirtuin-1 (Sirt-1) plays a crucial role in various biological processes including cellular senescence, metabolism, and inflammatory responses. Sirt-1 deacetylation regulates different transcription factors that are important for modulating immune responses. In the current study, we addressed the role of Sirt-1 in GVHD induction by employing Sirt-1 conditional knockout mice as well as a pharmacological Sirt-1 inhibitor. Using major histocompatibility complex (MHC)-mismatched and MHC-matched murine BMT models, we found that Sirt-1<sup>-/-</sup> T cells had a reduced ability to induce acute GVHD (aGVHD) via enhanced p53 acetylation. Sirt-1-deficient T cells also promoted induced regulatory T cell (iTreg) differentiation and inhibited interferon-γ production after allo-BMT. Sirt-1 deletion in iTregs increased Foxp3 stability and restrained iTreg conversion into pathogenic T cells. Furthermore, we found that administration with a Sirt-1 inhibitor, Ex-527, significantly improved recipient survival and clinical scores, with no signs of tumor relapse. These results indicate that Sirt-1 inhibition can attenuate GVHD while preserving the graft-versus-leukemia effect. Consistently, Sirt-1-deficient T cells also displayed a remarkably reduced ability to induce chronic GVHD (cGVHD). Mechanistic studies revealed that Sirt-1 deficiency in T cells enhanced splenic B-cell reconstitution and reduced follicular T helper cell development. Sirt-1 deficiency in T cells modulated donor B-cell responses reducing both B-cell activation and plasma cell differentiation. In addition, therapeutic Sirt-1 inhibition could both prevent cGVHD and reduce established cGVHD. In conclusion, Sirt-1 is a promising therapeutic target for the control of aGVHD and cGVHD pathogenesis and possesses high potential for clinical application.
Innovative materials and fabrication process to develop new RF components and concepts (2017)

This paper will give an overview of the possibilities offered by the additive manufacturing processes to create integrated passive components. After the presentation of different technologies (inkjet printing, polymer 3D printing, ceramic stereolithography) and associated materials, concepts of antennas and filters will be described along with measured results. The paper will specifically highlight what can be imagined when different passive functions are co-designed and merged in simple and monolithic 3D dielectric parts.
Electrothermal Analysis for Super-Junction TMOSFET with Temperature Sensor (2015)

For a conventional power metal-oxide-semiconductor field-effect transistor (MOSFET), there is a trade-off between specific on-state resistance and breakdown voltage. To overcome this trade-off, a super-junction trench MOSFET (TMOSFET) structure is suggested; within this structure, the ability to sense the temperature distribution of the TMOSFET is very important since heat is generated in the junction area, thus affecting its reliability. Generally, there are two types of temperaturesensing structures -diode and resistive. In this paper, a diode-type temperature-sensing structure for a TMOSFET is designed for a brushless direct current motor with on-resistance of 96 mmm 2 . The temperature distribution for an ultra-low on-resistance power MOSFET has been analyzed for various bonding schemes. The multi-bonding and stripe bonding cases show a maximum temperature that is lower than that for the single-bonding case. It is shown that the metal resistance at the source area is non-negligible and should therefore be considered depending on the application for current driving capability.
Retrovirus-mediated gene transfer in lungs of living fetal sheep. (1995)

In utero somatic gene transfer may be a useful therapeutic strategy for a variety of inherited disorders. In the present study, we demonstrate transgene expression in the airways of fetal lamb lungs, 2-3 weeks after injection of Moloney murine leukemia retrovirus based vectors containing cDNA for beta-galactosidase (lacZ) or human interleukin receptor antagonist protein (IRAP), into the fluid filled future airspace of fully catheterized twin fetal lambs (104-117 days gestational age; term 147 days). Expression of lacZ or IRAP was limited to the twin that received the respective vector and was apparent, at light microscopic level, in the epithelium and submucosal space of proximal airways, and to a lesser extent, in the respiratory epithelium of the distal airways. These data demonstrate for the first time that transfer of foreign DNA to fetal lung can be accomplished. These findings support the use of retroviral vectors for somatic lung DNA transfer and suggest that inherited disorders such as cystic fibrosis may be approached therapeutically via gene transfer, in utero.