gebhart/patrepeval huggingface dataset:
Does Lithium Deserve a Place in the Treatment Against COVID-19? A Preliminary Observational Study in Six Patients, Case Report (2020)

Lithium has shown the capacity to: a) inhibit the replication of several types of viruses, some of which are similar to the SARS-CoV-2 virus, b) increase the immune response by reducing lymphopenia, and c) reduce inflammation by preventing or reducing the cytokine storm. In the present study, we have treated six patients with severe COVID-19 infection with lithium carbonate. We found that lithium carbonate significantly reduced plasma reactive C-Protein levels, increased lymphocyte numbers and decreased the neutrophil-lymphocyte ratio, improving both inflammatory activity and the immune response in these patients. We propose that lithium carbonate may deserve a place in the treatment against COVID-19.
A Scalable Dual LFM Waveform for Unambiguous Localization in Distributed Antenna Arrays (2020)

Distributed antenna arrays, comprising a set of transceivers wirelessly-coordinated at the level of the RF wavelength, require high-accuracy localization to form beams in arbitrary directions. The phase relationship between the transmitted signals are corrected based on the beamsteering phase and the direction of interest, thus any error in the distance measurement will lead to degraded beamforming gain. Previously, it was shown that a spectrally-sparse two-tone waveform can achieve near-optimal localization accuracy between nodes, but results in ambiguous range measurements that must be accounted for. In this work, we present a novel waveform combining spectral sparsity for high-accuracy localization, modulation for range disambiguation, and time-frequency duplexing to enable scalability for accurate ranging between multiple nodes simultaneously.
Nonviral Expression of LL-37 in a Human Skin Equivalent to Prevent Infection in Skin Wounds (2021)

Inefficient autologous tissue recovery in skin wounds increases the susceptibility of patients to infections caused by multidrug resistant microorganisms, resulting in a high mortality rate. Genetic modification of skin cells has become an important field of study because it could lead to the construction of more functional skin grafts, through the overexpression of antimicrobial peptides that would prevent early contamination and infection with bacteria. In this study, we produce and evaluate human skin equivalents (HSEs) containing transfected human primary fibroblasts and keratinocytes by polyplexes to express the antimicrobial peptide LL-37. The effect of LL-37 on the metabolic activity of normal HSEs was evaluated before the construction of the transfected HSEs, and the antimicrobial efficacy against <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i> was evaluated. Subsequently, the levels of LL-37 in the culture supernatants of transfected HSEs, as well as the local expression, were determined. It was found that LL-37 treatment significantly promoted the cellular proliferation of HSEs. Furthermore, HSEs that express elevated levels of LL-37 were shown to possess histological characteristics close to the normal skin and display enhanced antimicrobial activity against <i>S. aureus in vitro</i>. These findings demonstrate that HSEs expressing LL-37 through nonviral modification of skin cells are a promising approach for the prevention of bacterial colonization in wounds.
Modeling, quantifying and testing complex aggregate service chains (2005)

Service chaining, the act of stringing a sequence of services together to form a new service, is a key element of Web services. However, for Web services to reach its full potential the issue of testing service-chaining at the network level must be resolved. How can one map the microlevel service-service interactions to the macrolevel system performance? For instance, as service chains become longer and more complex, how do they affect end-user quality of service? Focusing on aggregate service chains $situations in which the user invokes a service that carries out the chain, without the user being aware of the individual services - we tackle these questions using a Java simulation tool to model service chaining, visualize network traffic and quantify service chain complexity. We demonstrate that one can orchestrate very complex service chains in a simple distributed manner and quantify how service chain complexity affects end-user quality of service and network loading.
Zinc changes in blood and urine during cyclic pareteral nutrition: relationships with amino acid metabolism (1994)

Serum Zn, ultrafiltrable Zn and amino acids in serum and urine samples of twenty-seven patients receiving cyclic (12 h/24 h) parenteral nutrition were measured. These samples were collected in patients after a 12 h period of parenteral nutrition, and in the evening after 12 h without parenteral nutrition. The same determinations were performed in ten control subjects who followed the same sampling scheme. Total serum ultrafiltrable Zn showed no significant variations in the patients during parenteral nutrition, and was not significantly different in the two groups although the proportion of the Zn present in the ultrafiltrable fraction was elevated. Serum cystine levels were significantly higher (P = 0.05) in the patients than the control subjects, and cystine excretion was also higher in patients (P < 0.05) and increased after parenteral nutrition (56.0 (SE 6.5) v. 147.1 (SE 20.6) mumol/12 h; P < 0.001). Histidine levels did not vary significantly in serum after parenteral nutrition and were not different in the patients in comparison with the control subjects. Histidine excretion was not different in the two groups but increased significantly during parenteral nutrition (P < 0.05). Serum albumin was significantly depressed in the patients compared with the control subjects (45.3 (SE 1.5) v. 33.9 (SE 1.5) g/l; P < 0.001). These results suggest that cystine infusion and excretion relate to the changes occurring in serum Zn and in urinary Zn excretion.
Canadian goldenrod residues and extracts inhibit the growth of Streptomyces scabiei, the causal agent of potato common scab (2017)

Common scab is one of the most important diseases affecting potato crops worldwide. Using fresh residues and/or bio-products of Canadian goldenrod (Solidago canadensis) may offer an alternative to harmful conventional fumigants. In this study, we aimed to: (i) conduct a preliminary investigation of the utilization of S. canadensis to reduce common scab severity (Experiment 1), and (ii) determine the allopathic potentials of S. canadensis extracts on Streptomyces scabiei (also known as S. scabies), the most important soil pathogen responsible for causing common scab in North America (Experiment 2). Compared with control plants, preliminary results showed that adding 1.2 kg of fresh S. canadensis residue per m2 reduced scab severity by about 45% (Experiment 1). Furthermore, hexane and dichloromethane extracts of S. canadensis, at a concentration of 200 µg·mL−1, inhibited the growth of S. scabiei by about 97% (Experiment 2). These results were comparable with those using tetracycline (2.5 µg·mL−1), a known inhibitor of S. scabiei. Both experiments suggested that S. canadensis may represent a new approach for controlling potato common scab. More studies are required to better understand the mechanisms involved in S. canadensis induced reduction of common scab in order to standardize the approaches.
<title>Refraction mapping of translucent objects with Shack-Hartmann sensor</title> (1998)

Possibility is experimentally demonstrated of measuring refraction distribution in non-homogeneous translucent objects using Shack-Hartmann sensors. Holographic micro-lens matrix of 13 X 19 lenses with diameter 0.5 mm and focal length 80 mm operating with simple market available CCD array resulted in the sensitivity to wave front measurements corresponding to 0.01 (lambda) .
ChemInform Abstract: Synthesis of N2‐Ethoxyethyldiethylenetriamine‐N1,N1,N3,N3‐tetraacetic Acid and Its Reaction with Some Metallic Ions. (1986)

Abstract Durch Umsetzung von Bis‐(benzyliden)‐ diethylentriamin (I) mit β‐Ethoxyethylbromid (II), Hydrolyse der Az0methingruppen und Alkylierung der endständigen Aminogruppen mit Chloressigsäure wird die im Titel genannte Verbindung (V) hergestellt.
Biosynthetic Mechanisms of a Unique Ribitol Phosphate-containing Glycan by FKRP, a Ribitol Phosphate Transferase (2020)

We recently revealed that the muscular dystrophy-related O-mannosyl glycan of α-dystroglycan contains a tandem structure consisting of ribitol phosphate, a newly identified glycan constituent in mammals. This unique structure is formed by the ribitol phosphate transferases FKTN and FKRP. However, the synthetic mechanisms, in particular, the substrate recognition mechanism and catalytic machinery of these enzymes, are unknown. This review article initially outlines the synthetic mechanisms of O-mannosyl glycan of α-dystroglycan, illustrates the results of our recent structure-function analysis of FKRP, and finally introduces the latest findings regarding the mechanisms by which a ribitol phosphate is transferred to the glycan.
The RET51/FKBP52 complex and its involvement in Parkinson disease (2010)

The tyrosine kinase receptor RET51 is expressed in distinct families of neurons where it promotes different functions. FKBP52 is an immunophilin with neuroprotective effects on different kinds of neurons. In this paper, we demonstrate that RET51 activation by both glial cell line-derived neurotrophic factor (GDNF) and NGF triggers the formation of RET51/FKBP52 complex. The substitution of the tyrosine 905 of RET51, a key residue phosphorylated by both GDNF and NGF, disrupts the RET51/FKBP52 complex. NGF and GDNF have a functional role in dopaminergic (DA) neurons where RET51 and FKBP52 are expressed with a yet undefined function. To clarify if RET51/FKBP52 complex should exert its function in DA neurons, we used an indirect approach by screening the genes encoding for RET51 and FKBP52 in a group of 30 Parkinson's disease patients. The degeneration of DA neurons is the main feature of PD, which is associated to a complex multifactorial aetiology combining environmental, age-related and genetic factors. We found a compound heterozygous carrying two mutations in RET and FKBP52 that are sufficient to disrupt the RET51/FKBP52 complex, indicating its potential role in PD.
A New Approach to Demand Modelling and Optimisation in Pricing Decision Support Systems (2013)

Pricing decision support systems have been developed in order to help retail companies optimise their prices. This paper aims to enhance the essential forecasting and optimisation techniques that underlie these systems. This is first done by applying the method of Dynamic Linear Models in order to provide more accurate forecasts compared with current models. We also present a new pricing optimisation technique which provides the highest guaranteed profit when a competitor's price can't be forecasted. Existing optimisers assume that a competitor never reacts to a change in own price but this assumption can't be trusted since competitor prices are never forecasted. This new approach is applied to the forecasting and optimisation of daily retail vehicle fuel pricing using real commercial data, showing its improved results in both cases.
Nonchemical Bacteria-Control Process (2010)

Abstract This paper describes a proven method to control bacteria growth in pipeline and process service fluids using irradiation technology. Service fluids are exposed to an irradiation source that disinfects the fluids and eliminates the need for biocide chemistry. The disinfection process can be used as a standalone process or in conjunction with traditional chemical treatments for many oilfield service applications. The commissioning process for pipelines typically requires hydrostatic-pressure testing. The test fluid is usually treated for potential bacteria accumulation. Using the nonchemical process of irradiation to disinfect the test fluid eliminates the need for hundreds of gallons of bactericide. The service greatly reduces employee exposure to hazard-rated biocides and associated health- and safety-related issues, significantly improving overall environmental aspects of the operation. Bacteria play an important, although usually detrimental, role in the production and transportation of hydrocarbons. The slime- forming version of bacteria can corrode surface piping and storage facilities. In addition, bacteria have been known to restrict reservoir porosity with "bio-plugging" or "bio-fouling." One anaerobic form of bacteria is sulfate reducing bacteria (SRB), which reduces the sulfate ion to sulfide. This can lead to the corrosion of flow-wetted metal components and to the formation of hydrogen sulfide (H2S) gas, which is extremely hazardous to humans and other animals. Fluids containing H2S can be damaging to production facilities not specifically designed to be H2S resistant. The nonchemical alternative to biocide has cost and environmental advantages over traditional chemical treatments.
Novel preparation of N-protected amino acid active esters using 1,2,2,2-tetrachloroethyl carbonates (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel preparation of N-protected amino acid active esters using 1,2,2,2-tetrachloroethyl carbonatesMahmoud Jaouadi, Jean Martinez, Bertrand Castro, Gerard Barcelo, Gerard Sennyey, and Jean-Pierre SenetCite this: J. Org. Chem. 1987, 52, 12, 2364–2367Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/jo00388a005https://doi.org/10.1021/jo00388a005research-articleACS PublicationsRequest reuse permissionsArticle Views393Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The impact of thermal stratification and wind stress on sea surface features in SAR imagery (2011)

We have conducted high-resolution numerical experiments with the computational fluid dynamics (CFD) software ANSYS FLUENT on the dynamics of centerline ship wakes and rain-formed plumes in the presence of wind stress. The ship wake model is initialized with the velocity field from numerical simulations using a model with a ship hull and propellers. We then apply wind stress perpendicular to the centerline wake. We simulate SAR images with a radar imaging algorithm using the surface velocity field produced by the CFD model. Results show ship wake asymmetry since the wind stress enhances flow convergence upwind of the centerline wake and reduces it on the downwind side. The results are qualitatively consistent with available SAR images. We added a near-surface thermal stratification (e.g., diurnal thermocline) to the model during initialization and investigated the impact on the ship wake hydrodynamics. Stratification appears to influence the spreading of the wake, while the circulation in the wake can bring colder water to the surface. For the plume simulation, we initialize the model with a low-density plume imitating randomly distributed rainfall. The plume structure also shows asymmetry relative to the wind direction in simulated radar images.
Reactions of Manganese(III) Schiff Base Complexes with Superoxide Ion in Dimethyl Sulfoxide (1981)

Abstract The reactions of the chloromanganese(III) complexes of the Schiff bases derived from salicylaldehydes or β-diketones and diamines or monoamines with superoxide ion, O2−, in dimethyl sulfoxide were investigated. The complexes were found to react to give either the oxygenated Mn Schiff base complexes or the reduced Mn(II) Schiff base complexes. The difference in the reactivity toward O2− was correlated to the polarographic half-wave potentials corresponding to the reduction of Mn(III) to Mn(II) of the complexes. Some oxygenated complexes were isolated and characterized.
Generation of high-resolution dynamic wavefronts for speckle-based measurements of complex surface shapes (2015)

Due to the modulo-2π periodicity of the interferometric principle and diffraction occurring at steep surface height variations, the electronic speckle-pattern interferometry (ESPI) is restricted generally to continuous surfaces with minor structural density. With a dynamic reference wavefront adapted to the measurement object, the resolution of steep or filigree areas is feasible. The problems of the generation of high-resolution dynamic wavefronts (HRDWs) will be discussed, and a new method for the realization is presented. This paper shows first simulation results for the generation of HRDWs and their possible applications in ESPI.
Tungsten–niobium–sulfur composite nanotubes (2001)

Novel W–Nb–S composite inorganic nanotubes have been generated by replacing W in the S–W–S sandwich layers of WS2 by Nb. The tubes are uniform, with the Nb concentration 10 atom%. Raman spectral features of the tubes are described.
Self-Assembly of Elastin–Mimetic Double Hydrophobic Polypeptides (2013)

We have constructed a novel class of "double-hydrophobic" block polypeptides based on the hydrophobic domains found in native elastin, an extracellular matrix protein responsible for the elasticity and resilience of tissues. The block polypeptides comprise proline-rich poly(VPGXG) and glycine-rich poly(VGGVG), both of which dehydrate at higher temperature but form distinct secondary structures, β-turn and β-sheet respectively. In water at 45 °C, the block polypeptides initially assemble into nanoparticles rich in β-turn structures, which further connect into long (>10 μm), beaded nanofibers along with the increase in the β-sheet content. The nanofibers obtained are well-dispersed in water, and show thermoresponsive properties. Polypeptides comprising each block component assemble into different morphologies, showing that the conjugation of poly(VPGXG) and poly(VGGVG) plays a role for beaded fiber formation. These results may provide innovative ideas for designing peptide-based materials but also opportunities for developing novel materials useful for tissue engineering and drug delivery systems.
A modified version of Larsen's scoring method to assess radiologic changes in rheumatoid arthritis. (1995)

We describe the development and application of a modified version of the radiologic scoring method proposed by Larsen in patients with rheumatoid arthritis (RA). We modified Larsen's method adding a semiquantitative description of the loss of joint surface area and provide standardized reference films for all stages at different anatomical sites (metacarpophalangeal joints, proximal interphalangeal joints, wrists, metatarsophalangeal joints). To evaluate the method, standard anteroposterior radiographs of hands, wrists and forefeet of 24 patients with early erosive RA taken at baseline (t0) and after 36 months (t1) were read by 2 raters in a blinded fashion. The interrater difference was compared with the interpatient (t0 to t1) difference using a hierarchical analysis of variance. Moreover, the method was applied to patients included in a 2 year clinical trial to evaluate the efficacy of intramuscular methotrexate (MTX) and gold sodium thiomalate (GSTM) with radiographs taken at baseline and after 6, 12, and 24 months. There was a good agreement between the 2 raters and the change could be well documented. The estimation of the intrapatient variance (at t0 and t1) was 8 times higher than the estimation of the interreader variance. The method was easily applicable in 57 patients treated with MTX and 53 patients under treatment with GSTM, showing a slowing of radiologic progression after Month 6 with both drugs. The modification of Larsen's scoring method is a reliable measure to assess baseline status and radiologic progression in patients with RA.
Ligand effect on the catalytic activity of porphyrin-protected gold clusters in the electrochemical hydrogen evolution reaction (2017)

The "ligand effect" can be used as a novel strategy for enhancing the catalytic properties of metal clusters. Herein, we report the ligand effect of porphyrin derivatives on gold clusters (AuCs, size <2 nm) and gold nanoparticles (AuNPs, size >2 nm) in the electrochemical hydrogen evolution reaction (HER) at pH 6.7. The current density of porphyrin face-coordinated AuCs at -0.4 V <i>vs.</i> reversible hydrogen electrode (RHE) was 460% higher than that of phenylethanethiol-protected AuCs. X-ray photoemission spectroscopy indicated that the approach of porphyrin to the Au surface induced charge migration from the porphyrin to the Au core, leading to a shift in the 5d state of AuCs that resulted in enhanced HER activities. This ligand effect is pronounced in the cluster region due to the large surface-to-volume ratio. These results pave the way for enhancing catalytic activity of metal clusters using ligand design.
A probabilistic approach to color constancy using articulation, brightness, and gamut cues (2010)

The neural mechanisms underlying color constancy remain poorly understood. It is generally accepted that the key operation underlying color constancy is the estimation of the scene illuminant(s), but as illuminant estimation has proven to be a very difficult computational problem, color constancy algorithms continue to fall far short of human performance. Many existing color constancy algorithms attempt to determine the illuminant based solely on the information contained within the scene. We have developed a Bayesian-inspired approach to color constancy involving the following five heuristics: (1) the most probable illuminant in a scene lies along the line (in color space) that connects the scene average M and the a priori most probable illuminant L; (2) the scene average M is computed using a single chromaticity estimate per object surface (i.e. one surface one vote), rather than a single estimate per image pixel; (3) object surface contributions to the scene average M are weighted by surface brightness, reflecting the well known brightest-is-illuminantest principle; (4) scenes with high surface counts, which contain relatively more illuminant information, pull illuminant estimates radially outward towards M; and (5) scenes with large color gamuts pull the illuminant estimate radially inward towards L. To test our algorithm, we developed (1) a database methodology in which we produce large numbers of color image composites with varying backgrounds constructed from the images of 100 real objects shot under 5 different illuminants, and (2) a color-histrogramming recognition benchmark which we have used to test our approach to color constancy against several other published algorithms. In our most recent tests, our algorithm achieved 67.4% recognition rates compared to 37.4% for unprocessed images, outperforming all other algorithms tested.