gebhart/patrepeval huggingface dataset:
The Radiation-Induced Addition Reaction of Alcohols to 1,2-Dichlorotetrafluorocyclobutene and 1,2-Dichlorohexafluorocyclopentene (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Radiation-Induced Addition Reaction of Alcohols to 1,2-Dichlorotetrafluorocyclobutene and 1,2-DichlorohexafluorocyclopenteneHiroshige Muramatsu, Kan Inukai, and Teruo UedaCite this: J. Org. Chem. 1965, 30, 8, 2546–2549Publication Date (Print):August 1, 1965Publication History Published online1 May 2002Published inissue 1 August 1965https://pubs.acs.org/doi/10.1021/jo01019a011https://doi.org/10.1021/jo01019a011research-articleACS PublicationsRequest reuse permissionsArticle Views42Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Corner Junction as a Probe of Helical Edge States (2008)

We propose and analyze inter-edge tunneling in a quantum spin Hall corner junction as a means to probe the helical nature of the edge states. We show that electron-electron interactions in the one-dimensional helical edge states result in Luttinger parameters for spin and charge that are intertwined, and thus rather different than those for a quantum wire with spin rotation invariance. Consequently, we find that the four-terminal conductance in a corner junction has a distinctive form that could be used as evidence for the helical nature of the edge states.
COMPRESSIVE RHEOLOGY : AN OVERVIEW (2003)

Compressive rheology, or the behaviour of suspensions in sedimentation and compression has been widely studied and many theories, using different physical quantities, have evolved in parallel. This review article provides a basis for the reconciliation of these approaches via presentation of the Buscall-White (1987) approach to consolidation, which uses a compressive yield stress, Py(φ), and a hindered settling factor, R(φ), to quantify the strength of a particle network in compression and the inter-phase drag respectively, and linking it to other theories and related de-watering parameters available in the literature. The links between behaviour of a concentrated particle system in shear and compression are then discussed and a review of the various experimental methods available for determination of the dewatering parameters is presented. The final section overviews the practical application, benefits and limitations of models for real de-watering processes.
Successful treatment of BRAF/MEK inhibitor‐resistant advanced cutaneous melanoma with nivolumab plus ipilimumab combination therapy followed by intensity‐modulated radiotherapy (2021)

BRAF kinase inhibitors in combination with MEK kinase inhibitors are among the most promising chemotherapeutic regimens for the treatment of advanced BRAF-mutant melanoma. Although the NCCN guideline for cutaneous melanoma recommended BRAF/MEK inhibitors as first-line therapies for unresectable BRAF-mutated melanoma, resistance to these drugs should be taken into account in real-world practice. Therefore, development of a protocol for BRAF/MEK inhibitor-resistant advanced melanoma is needed. In this report, a case of BRAF/MEK inhibitor-resistant advanced cutaneous melanoma that was successfully treated with nivolumab plus ipilimumab combination therapy followed by intensity-modulated radiotherapy (IMRT) is reported. In the present case, not only the locally irradiated lesion, but remote metastases including inguinal lymph nodes decreased after ipilimumab plus nivolumab followed by IMRT treatment leading to complete remission, suggesting that IMRT triggered an abscopal response. Moreover, immunohistochemical analysis showed increased CD3<sup>+</sup> , CD4<sup>+</sup> , and CD8<sup>+</sup> T cells after radio-immunotherapy (RIT). This case suggests that RIT might break the tolerance in the tumor microenvironment and induce a systemic anti-melanoma immune response.
Three-Dimensional Water Channel Embedded in an α,γ-Cyclic Octapeptide-Derived Organic Porous Material (2011)

A dual behavior for water is described, in which the water molecules play an active role in inducing a cyclic peptide to fold and assemble to produce a novel three-dimensional porous organic solid without any interpeptide hydrogen bonds, and at the same time, the water molecules fill the voids left by the cyclic peptide (CP) aggregate to form highly ordered 3D water channels at room temperature through large interconnected water clusters. Once the crystal is taken out of the mother liquor, it slowly loses its water content while increasing its crystal symmetry from P21 to I2.
Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion (2011)

The ability of cells to respire requires that mitochondria undergo fusion and fission of their outer and inner membranes. The means by which levels of fusion 'machinery' components are regulated and the molecular details of how fusion occurs are largely unknown. In Saccharomyces cerevisiae, a central component of the mitochondrial outer membrane (MOM) fusion machinery is the mitofusin Fzo1, a dynamin-like GTPase. We demonstrate that an early step in fusion, mitochondrial tethering, is dependent on the Fzo1 GTPase domain. Furthermore, the ubiquitin ligase SCF(Mdm30) (a SKP1-cullin-1-F-box complex that contains Mdm30 as the F-box protein), which targets Fzo1 for ubiquitylation and proteasomal degradation, is recruited to Fzo1 as a consequence of a GTPase-domain-dependent alteration in the mitofusin. Moreover, evidence is provided that neither Mdm30 nor proteasome activity are necessary for tethering of mitochondria. However, both Mdm30 and proteasomes are critical for MOM fusion. To better understand the requirement for the ubiquitin-proteasome system in mitochondrial fusion, we used the N-end rule system of degrons and determined that ongoing degradation of Fzo1 is important for mitochondrial morphology and respiration. These findings suggest a sequence of events in early mitochondrial fusion where Fzo1 GTPase-domain-dependent tethering leads to recruitment of SCF(Mdm30) and ubiquitin-mediated degradation of Fzo1, which facilitates mitochondrial fusion.
Co-operative location update algorithm for mobiles in next generation cellular networks (2004)

In cellular networks, occasional location updates to the base station by a mobile terminal are critical in order to route incoming calls successfully and also to maintain ongoing communication uninterrupted. In current cellular systems, the location update algorithm is implemented on a one-to-one basis, i.e. each mobile updates its location information directly with the base station following a specific set of rules. For next generation systems, a highly dense network in terms of total number of mobile users in a particular base station area is anticipated. The one-to-one location update method could prove to be very costly in terms of total traffic generated between mobiles and base stations due to the location update messages. The average battery energy used by each mobile is another aspect of the cost associated with location updates. In this work, we propose a new location update algorithm called co-operative location updates. In this scheme, a mobile terminal collects location information from its neighbors who are ready to update their locations and transmits all information to the base station along with its own location information. Such collective updating on the part of a single mobile terminal results in significant reduction in the signaling traffic to the base station. Our results also show that the mobile terminal survives a larger number of location updates, implying more efficient usage of battery energy under the proposed cooperative updating scheme.
Thematic mapping - from unstructured documents to taxonomies (2002)

Verity Inc. has developed a comprehensive suite of tools for accurately and efficiently organizing enterprise content which involves four basic steps: (i) creating taxonomies, (ii) building classification models, (iii) populating taxonomies with documents, and (iv) deploying populated taxonomies in enterprise portals. A taxonomy is a hierarchical representation of categories. A taxonomy provides a navigation structure for exploring and understanding the underlying corpus without sifting through a huge volume of documents. Thematic Mapping automatically discovers a concept tree from a corpus of unstructured documents and assigns meaningful labels to concepts based on a semantic network. Integrating with Verity Intelligent Classifier's user-friendly GUI, a user can drill down a concept tree for navigation, perform a conceptual search to retrieve documents pertaining to a concept, build a taxonomy from the concept tree, as well as edit a taxonomy to tailor it into various views (customized taxonomies) of the same corpus. Classification rules can be generated automatically from concepts. These classification rules can be used for populating documents into the taxonomy.
Crowdsourcing Awareness: Exploration of the Ovarian Cancer Knowledge Gap through Amazon Mechanical Turk (2014)

Knowledge of ovarian cancer was compared to that of breast cancer using repeated measures, bias control and other quality control measures in the survey design. Analyses included multinomial logistic regression and categorical data analysis procedures such as correspondence analysis, among other statistics. We confirmed the relatively poor public knowledge of ovarian cancer among the US population. The simple, yet novel design should set an example for designing surveys to obtain quality data via Amazon Mechanical Turk with the associated analyses.
ChemInform Abstract: 2‐(3‐ARYL‐5‐PYRAZOLYL)BENZOIC ACID CHEMISTRY (1976)

Abstract Aus den Pyrazolo‐isoindolinonen (I) entstehen bei der nucleophilen Ringöffnung mit Wasser, Alkoholen oder Aminen Pyrazolyl‐benzoesäuren oder deren Derivate (II).
Band structure ofCsSnBr3 (1990)

The band structure of cubic ${\mathrm{CsSnBr}}_{3}$ is determined by an empirical pseudopotential method. Independent of the choice of the parameters used in the calculation, cubic ${\mathrm{CsSnBr}}_{3}$ is shown to be a zero-band-gap semiconductor. Based on this result, a new interpretation of the experimental data is proposed.
A remotely operated, automated system for the infusion of shielded therapeutic radiopharmaceuticals (1999)

Macfarlane, D. J.; Bartlett, M.; Bellen, J.; Peters, J.; Domagala, M.; Allison, R. Author Information
Design and Analysis of Voltage Control for Islanded DC Microgrids Based on a Fuzzy-PI Controller (2023)

In the transition to clean, cheap, and sustainable energy, microgrid-based renewable energy resources (RES) are widely utilized in islanded or grid-connected modes. However, due to the intermittent nature of RES such as photovoltaic (PV) or wind energy systems, energy storage systems (ESSs) such as batteries are mandated to satisfy load demands and stabilize system operation. For instance, stabilizing the dc bus voltage in islanded microgrids is crucial to keeping the system reliable, dependable, and stable. This paper proposes an adaptive dc bus voltage control technique based on a fuzzy-PI controller. Moreover, a performance comparison between fuzzy-PI and conventional proportional-integrator (PI) controllers is performed based on a MATLAB/Simulink model. The results show that the fuzzy-PI controller has a faster response to any reference voltage variation and less overshoot compared to conventional PI controllers. Additionally, the proposed controller can efficiently stabilize the dc bus voltage during load variation portions.
A recombinant single‐chain antibody fragment that neutralizes toxin II from the venom of the scorpion Androctonus australis hector (1999)

Monoclonal antibody 4C1 specifically binds to and neutralizes the most potent neurotoxin (AahII) of the scorpion Androctonus australis . The cDNAs encoding the variable regions of this antibody were isolated by PCR‐mediated cloning. A single‐chain Fv gene was engineered and expressed in Escherichia coli . The recombinant protein had neutralizing activity similar to that of the intact antibody in vitro and in vivo. We have thus neutralized the pharmacological and biological properties of a scorpion neurotoxin with a single‐chain Fv, which opens new perspectives for the treatment of envenomizations.
Reflective interference study of binding nikelions on nitrilotriacetic (nta) nanoporous alumina chips for detections of his-tagged proteins (2012)

In this report, the application of a label-free reflectometric interference spectroscopy (RIfS) using nanoporous anodic aluminium oxide (AAO) to study of binding kinetics of nickel ions to self-assembled monolayers (SAMs) of nitrilotriacetic (NTA) chelates is presented. Highly ordered nanoporous AAO fabricated by electrochemical anodization of aluminium foil was used as the RIfS sensing platform. SAM of alkanethiol (C2) terminated with NTA functional group that specifically binds to Ni2+ ions was covalently attached to gold coated AAO surface using simple self-assembly process. The binding of Ni2+ ions to NTA-Au-AAO chip using different concentrations (0.1 mM to 100 mM) was monitored by RIfS spectroscopy in a steady state conditions. Our results show that RIfS optical system using functionalised nanopore AAO arrays is capable of detecting real-time binding and binding kinetics of Ni2+ ions on NTA ligands. This optical method shows a great promise to be used as generic method for studying molecular binding kinetics for other analytes including metal ions, proteins, DNA and antibodies. Furthermore, the approach can be easily translated into a rapid and cost-effective biosensing device for the detection and purification of histidine tagged genetically engineered proteins relevant to proteomics.
Laboratory Assessment of a Headband-Mounted Sensor for Measurement of Head Impact Rotational Kinematics (2020)

Head impact sensors measure head kinematics in sports, and sensor accuracy is crucial for investigating the potential link between repetitive head loading and clinical outcomes. Many validation studies mount sensors to human head surrogates and compare kinematic measures during loading from a linear impactor. These studies are often unable to distinguish intrinsic instrumentation limitations from variability caused by sensor coupling. The aim of the current study was to evaluate intrinsic sensor error in angular velocity in the absence of coupling error for a common head impact sensor. Two Triax SIM-G sensors were rigidly attached to a preclinical rotational injury device and subjected to rotational events to assess sensor reproducibility and accuracy. Peak angular velocities between the SIM-G sensors paired for each test were correlated (R2 > 0.99, y = 1.00x, p < 0.001). SIM-G peak angular velocity correlated with the reference (R2 = 0.96, y = 0.82x, p < 0.001); however, SIM-G underestimated the magnitude by 15.0% ± 1.7% (p < 0.001). SIM-G angular velocity rise time (5% to 100% of peak) correlated with the reference (R2 = 0.97, y = 1.06x, p < 0.001) but exhibited a slower fall time (100% to 5% of peak) by 9.0 ± 3.7 ms (p < 0.001). Assessing sensor performance when rigidly coupled is a crucial first step to interpret on-field SIM-G rotational kinematic data. Further testing in increasing biofidelic conditions is needed to fully characterize error from other sources, such as coupling.
AST Development in M2FCT (ASTWG and iDWG) Update to 21CTP [Slides] (2022)

Accelerated Stress Tests (ASTs) are required to evaluate fuel cell component durability in a reasonable time. Current DOE and FCTT ASTs are light duty focused with 5000 – 8000 hour durability requirements. Heavy duty ASTs need to reflect the 25000+ hour durability requirement. Interim solution is to extend the duration of the current light duty ASTs: Catalyst AST has been extended from 30,000 cycles to 90,000 cycles (From 50 hours to 150 hours). We need to understand Heavy duty stressors and tailor ASTs for heavy duty applications: Longer lifetimes; Higher efficiencies – Higher loadings - Potentially higher operating temperatures and voltages; Heat rejection during low speed hill climbs – Higher operating temperature; Longer Idling times – Higher operating voltages and drier operation; Take into account different hybridization strategies (Vary size of battery).
Two-Layer Method of Image Retrieval Based on Global Color Histogram and Local Color Spatial Features (2007)

A new method based on two layers image retrieval is proposed. The first layer retrieval feature is global color histogram and the second one consists of the local color histogram, the averages and variances of the multi-scaling 2D wavelet decomposition coefficients. Difference weights are assigned to every block according to the importance of its spatial distribution. This method combines the advantages of the global and the local color histogram, thereby achieving the better retrieval performance.
Conserved Acidic Amino Acid Residues in a Second RNA Recognition Motif Regulate Assembly and Function of TDP-43 (2012)

Accumulating evidence suggests that pathogenic TAR DNA-binding protein (TDP)-43 fragments contain a partial RNA-recognition motif domain 2 (RRM2) in amyotrophic lateral sclerosis (ALS)/frontotemporal lobar degeneration. However, the molecular basis for how this domain links to the conformation and function of TDP-43 is unclear. Previous crystal analyses have documented that the RRM2-DNA complex dimerizes under acidic and high salt conditions, mediated by the intermolecular hydrogen bonds of Glu246-Ile249 and Asp247-Asp247. The aims of this study were to investigate the roles of Glu246 and Asp247 in the molecular assembly of RRM2 under physiological conditions, and to evaluate their potential use as markers for TDP-43 misfolding due to the aberrantly exposed dimer interface. Unexpectedly, gel filtration analyses showed that, regardless of DNA interaction, the RRM2 domain remained as a stable monomer in phosphate-buffered saline. Studies using substitution mutants revealed that Glu246 and, especially, Asp247 played a crucial role in preserving the functional RRM2 monomers. Substitution to glycine at Glu246 or Asp247 induced the formation of fibrillar oligomers of RRM2 accompanied by the loss of DNA-binding affinity, which also affected the conformation and the RNA splicing function of full-length TDP-43. A novel monoclonal antibody against peptides containing Asp247 was found to react with TDP-43 inclusions of ALS patients and mislocalized cytosolic TDP-43 in cultured cells, but not with nuclear wild-type TDP-43. Our findings indicate that Glu246 and Asp247 play pivotal roles in the proper conformation and function of TDP-43. In particular, Asp247 should be studied as a molecular target with an aberrant conformation related to TDP-43 proteinopathy.
In Vitro Action of Various Chemical Agents on Trichomonas Hominis, Trichomonas Vaginalis and Trichomonas Foetus, (1948)

Abstract Trichomonads are actively motile, flagellated, pear-shaped protozoa which occur widely as parasites in man and other animals. Infections may vary in degree of severity depending on the individual host reaction, but they are generally difficult to eradicate. Many types of treatment are recommended, but no reliably efficient chemotherapeutic agents are available; therapeutic procedures are largely empirical and therapy is apt to be uncertain and unsatisfactory. Attempts to infect animals with bacteria-free cultures of Trichomonas vaginalis (1) have met with little success. In this laboratory, rabbits could not be infected by Trichomonas hominis inoculated intravaginally, and experimental infections of Trichomonas foetus in the vagina of the rabbit are too irregular and unpredictable for practical in vivo tests (2–4). Therefore, in vitro tests on clinical material or on cultures of the organisms remain as a basis for evaluating drugs, particularly for substances which may be expected to act promptly.
Pervasive tandem duplications and convergent evolution shape coral genomes (2022)

Abstract Over the last decade, several coral genomes have been sequenced allowing a better understanding of these symbiotic organisms threatened by climate change. Scleractinian corals are reef builders and are central to these ecosystems, providing habitat and food to a great diversity of species. In the frame of the Tara Pacific expedition, we generated two coral genomes, Porites lobata and Pocillopora meandrina with vastly improved contiguity that allowed us to study the functional organisation of these genomes. We annotated their gene catalog and report a relatively higher gene number (43,000 and 32,000 genes respectively) than that found in other public coral genome sequences. This finding is explained by a high number of tandemly duplicated genes (almost a third of the predicted genes). We show that these duplicated genes originate from multiple and distinct duplication events throughout the coral lineage. They contribute to the amplification of gene families, mostly related to immune system and disease-resistance, which we suggest to be functionally linked to coral host resilience. At large, we show the importance of duplicated genes to inform the biology of reef-building corals and provide novel avenues to understand and screen for differences in stress resilience.
Seismic mis-tie resolution technique (1991)

Abstract Efficient resolution of seismic time mis-ties within a survey can be critical to the successful generation of a prospect. A mathematical technique for the automatic resolution of mis-ties is presented that determines an optimal set of bulk time corrections to be applied to each line in a survey. A bulk time correction for a seismic line is a static time shift that is applied to every point on the line, thus preserving the dip of each seismic line. Dynamic time shifts that can vary over a seismic line are not addressed here. Solutions are presented for both the fully determined case and the over-determined case where the squared error (or squared mis-tie) is minimized. A mathematical weight, associated with each seismic line, is utilized within the technique to reflect line quality, desirability, vintage, or some other line attribute. The utilization of this technique extends beyond merely obtaining a set of optimal corrections for each seismic line. Problem lines may be identified for closer scrutiny, bulk time corrections for a group of lines as a function of vintage can be estimated, and statistical analyses can be performed on the results due to the least-squares nature of the technique.