gebhart/patrepeval huggingface dataset:
Author response: 3DeeCellTracker, a deep learning-based pipeline for segmenting and tracking cells in 3D time lapse images (2021)

A deep learning-based pipeline was developed for extracting cellular signals flexibly from moving cells in 3D time lapse images, and it outperformed previous methods under different imaging conditions.
A bioenergetic mechanism for amoeboid-like cell motility profiles tested in a microfluidic electrotaxis assay (2017)

Correction for 'A bioenergetic mechanism for amoeboid-like cell motility profiles tested in a microfluidic electrotaxis assay' by Hagit Peretz-Soroka et al., Integr. Biol., 2017, DOI: .
Zustandsänderungen von polymeren Netzwerken bei Orientierung (1973)

Die erhöhte Neigung eines Polymeren, durch Deformation auch oberhalb der Schmelztemperatur der isotropen Probe zu kristallisieren, ist ein lange bekanntes Phänomen (1). Es wurde zuerst an Naturkautschuk beobachtet, erweist sich aber als eine allgemein verbreitete Eigenschaft vieler Polymerer. Dabei werden die Kristallite als gut orientiert, mit ihrer Kettenachse parallel zur Verstreckrichtung beobachtet. Die uniaxiale Dehnung — nur diese soll in dieser Arbeit betrachtet werden — zwingt der polymeren Probe eine orientierte Struktur auf, die durch Relaxationsprozesse, insbesondere Fließprozesse, nicht abgebaut werden kann, wenn die Ketten durch Verknüpfungen ein Netzwerk bilden. Die Konfigurationsentropie der einzelnen gedehnten Kette ist herabgesetzt, und dadurch wird die Tendenz, sich in kristalline Bereiche einzuordnen, ganz offensichtlich erhöht.
Comparative Experimental and Molecular Simulation Study of the Entropic Viscoelasticity of End-Linked Polymer Networks (2020)

Bifunctional vinyl-terminated poly(dimethylsiloxane) chains are end-linked by tetrafunctional tetrakis(dimethylsiloxy)silane cross-linkers to produce irregular polymer networks with controlled stoichiometric imbalance and extent of reaction. The results are used as input to create comparative, nominally the same, three-dimensional Monte Carlo computer microstructures. Stress relaxation laboratory measurements and bead-spring molecular dynamics (MD) simulations are performed to estimate the relaxation shear modulus. It is found that the MD estimates reproduce quite well the measured equilibrium shear modulus G, despite the strikingly different time scales of measured and MD relaxation moduli. However, it is also seen that for near-stoichiometric networks the classical affine network model (ANM) gives equally good predictions of G. Additional MD simulations with phantom strands and regular networks are carried out. It is demonstrated that the ANM success is accidental since it is based on the fortuitous cancellation of two unrelated inaccurate assumptions of regular defect-free polymer networks and phantom strands that can freely pass through each other and themselves. Several contemporary theories of the elasticity of ideal Gaussian polymer networks are considered, and it is demonstrated that none of them is particularly suitable for predicting the shear modulus of the studied end-linked polydimethylsiloxane (PDMS) networks. It is shown that by taking into account the effects of trapped entanglements, reasonable qualitative and, at times, even semiquantitative predictions can be achieved. However, because of the ambiguity problems in the empirical fitting of the effective concentration of trapped entanglements, the resulting theoretical predictions are overall notably less accurate and less reliable than those obtained with the coarse-grained MD simulations that automatically account for the uncrossability of network strands. This emphasizes the incompleteness of the current theoretical descriptions of the effects of entanglements on the elastic behavior of irregular end-linked polymer networks with various values of the extent of reaction and stoichiometric imbalance and also suggests using our validated Monte Carlo microstructures to further study these effects.
Thermal-aware synthesis of integrated photonic ring resonators (2014)

Photonic ring-resonators are key components of many on-chip optical-interconnect wavelength division multiplexing (WDM) network architectures. Thermal interactions between on-chip heat-sources and ring resonators pose significant operational and integration challenges, as these devices are extremely sensitive to temperature-induced changes in refractive index. Contemporary literature proposes active compensation for such refractive index variations (e.g. carrier-injection based tuning and/or WDM channel remapping); however, these are costly in terms of power and area. This paper presents a thermal-aware synthesis approach for ring-resonator compensation. We show how ring-resonators are analyzed in the presence of external thermal gradients, and employ a perturbation analysis to derive an equivalent, trimming-enabled, ring-resonator design. Our methodology produces a design-template that can be used to compensate for thermal variations through modifications to the waveguide's geometric structure. This approach complements active compensation techniques, and the synthesis is compatible with contemporary lithographic methods. Using this approach, we perform design space exploration with respect to variations to the waveguide structure and their effect on the range and precision of thermal compensation.
Pioneering Technology Solutions for Extended Reach Wells - High Expansion Coiled Tubing Tractor (2022)

Abstract Well intervention in horizontal extended reach wells (ERWs) comes with a myriad of challenges and in the case of coiled tubing the overarching impediment is in reaching the target depth (TD). Frictional forces act against the coiled tubing (CT) while being pushed from surface, this eventually leads to helical buckling of the tubing and early lockup where no further progress is made. Advances have been made over the last decade with the development of high-tech downhole CT tractors that deliver a strong pulling force to overcome these frictional forces. Restrictions in the well completion require these tractors to collapse to 2-1/8″, and then to expand to the cased or open hole size of up to 6-1/8″. With many wells having a larger bore size of 8-1/2″, a CT tractor did not exist to improve the coverage in those type of wells. At first glance, modifying the existing tractor for 6-1/8″ sized holes to function in 8-1/2″ sized holes could be accomplished by simply extending the lengths of the arms. However, the reality is a little more nuanced with several innovations required to deliver the same pulling force as the 6-1/8″ tractor version. This new generation of downhole compact high expansion tractors have improved push-links and newly designed grippers to enable rig-less acid stimulation and production logging in ERWs. The high expansion tractor is an important facilitator in CT well interventions to tackle challenging ERWs by increasing the coverage in 8-1/2″ hole sizes. The CT tractor design, development, testing and first deployment was conducted in 2021. The major advantages gained from increasing the reach can be summarized as follows: The CT high expansion tractor enables successful reservoir surveillance and production monitoring, including improved reservoir understanding providing data to update and calibrate reservoir models. Acid stimulation in 8-1/2″ open hole wells on CT targeted fluid placement to improve well productivity to increase revenue per well. Detecting and then shutting off water inflow zones with CT techniques, avoiding the need for drilling a side track. This new generation of slim tractors is the first in the industry to operate in wells with a diameter of 8-1/2″ and an operating range from 8″ to 10″. The key metric to successful acid stimulation or logging applications in ERWs is the ability to achieve maximum coverage of the openhole section. These engineered solutions demonstrate how creative innovations in technology design are improving accessibility in ERWs, resulting in superior reservoir management outcomes.
Substructuring preconditioning for finite element approximations of second order elliptic problems. II. Mixed method for an elliptic operator with scalar tensor (1994)

This work continues the series of papers in which new approach of constructing algebraic multilevel preconditioners for mixed finite element methods for second order elliptic problems with tensor coefficients on general grid is proposed. The linear system arising from the mixed methods is first algebraically condensed to a symmetric, positive definite system for Lagrange multipliers, which corresponds to a linear system generated by standard nonconforming finite element methods. Algebraic multilevel preconditioners are then constructed for this system based on a triangulation of parallelepipeds into tetrahedral substructures. Explicit estimates of condition numbers and simple computational schemes are established for the constructed preconditioners. Finally, numerical results for the mixed finite element methods are presented to illustrate the present theory.
The SmartTer for ELROB 2006 - a vehicle for fully autonomous navigation and mapping in outdoor environments (2006)

The goal of our participation ELROB 2006 is to show fully autonomous navigation and 3D mapping in outdoor setting. Our robots is based on a standard Smart car that has been equipped with five distance laser sensors, three cameras, a differential GPS and an Inertial Measurement Unit (IMU) and four computers. The car’s systems states are directly accessed through the can bus. Localization and Navigation is realized by fusing all available sensory information in a probabilistic way. This enables us for high precision localization and dynamic local and global path planning. Using the 3D point clouds extracted from the rotating lasers and the omnidirectional image the smartTer is able to consistently register the 3D Maps and Analyze the Scene for regions of interest.
Plasma-Assisted MOCVD Growth of Superconducting NbN Thin Films Using Nb Dialkylamide and Nb Alkylimide Precursors (2001)

The first example of the use of metal–organic precursors for depositing NbN superconducting thin films is described. The study, which employed niobium(IV) and niobium(V) (see Figure) pulsed source precursors and hydrazine plasma as the nitrogen source, indicates that Tc is highly dependent on the lattice parameters and level of oxygen impurities, which are in turn governed by growth and post-deposition annealing temperatures.
Recent progress in understanding the congenital neutropenias (2009)

University of Washington School of Medicine, Seattle, Washington, USA Correspondence to David C. Dale, MD, Professor of Medicine, University of Washington School of Medicine, Box 356422, 1959 NE Pacific St, Rm AA522, Seattle, WA 98195, USA E-mail: [email protected]
Modified FOLFOX in combination with docetaxel for patients with metastatic adenocarcinoma of the stomach or gastroesophageal junction: A multicenter phase II study of the Arbeitsgemeinschaft Internistische Onkologie (AIO) (2007)

4545 Background: The combination of docetaxel, cisplatin, and fluorouracil (DCF) is clearly superior to CF in the treatment of patients (pts) with advanced gastric cancer (AGC). DCF is, however, associated with significant toxicity, including neutropenia, febrile neutropenia, diarrhea and mucositis. This study evaluated a biweekly, oxaliplatin-based modification of DCF. Methods: Pts with measurable, locally advanced or metastatic adenocarcinoma of the stomach or GE-junction and no prior chemotherapy received mFOLFOX (oxaliplatin 85 mg/sqm, leucovorin 200 mg/sqm, and fluorouracil 2.6 g/sqm via 24hr infusion) in combination with docetaxel 50 mg/sqm on day 1 every 2 weeks (FLOT-regimen). Prophylactic G-CSF was not administered. Overall response rate (RR) was the primary endpoint (power 80% to detect a RR of &gt;40%) and toxicity profile the main secondary endpoint. The study was externally monitored according to GCP and data were reviewed by an independent safety board. Results: 59 pts (male, 41; female, 18) were enrolled. At the time of analysis, 53 pts were evaluable for toxicity and 51 pts for response. Median age was 60 (range, 29–76), median ECOG PS was 1, and almost all (93%) pts had metastatic disease. Of 51 pts, 2 had a CR and 25 pts attained a PR, adding to an overall RR of 53% (ITT-analysis). Stable disease was observed in 12 (23.5%) and progressive disease in 6 (11.8%) pts. Six (11.8%) pts were not evaluable for response. NCI-CTC grade 3 or 4 hematologic toxicity included leukopenia in 12 (22.6%), neutropenia in 23 (43%), and anemia in 2 (3.8%) pts. Febrile neutropenia was observed in 1 (1.9%) pt only. Other grade 3 or 4 toxicities included peripheral neuropathy in 4 (7.5%), nausea in 3 (5.7%), vomiting in 2 (3.8%) as well as diarrhea and fatigue in 5 (9.4%) pts each. No treatment related deaths were observed. Conclusions: FLOT is active and has a favorable toxicity profile in the treatment of pts with AGC. It may show activity also in perioperative treatment settings and may be considered as a useful treatment option for elderly pts. Survival data will be presented at the meeting. [Table: see text]
Interleukin 4 (IL) 4 up‐regulates gene and surface IL 1 receptor type I in murine T helper type 2 cells (1992)

The T cell-derived cytokine interleukin (IL) 4 is known to increase the proliferative response of T cells stimulated with IL 1. IL 4 is also an autocrine growth factor for type II T helper cells (Th2) cells. In the present studies, we examined the effect of murine recombinant IL 4 on the expression of the IL 1 receptor type I (IL 1RtI) in murine Th2 cell lines at the mRNA and surface level. Using a specific anti-murine IL 1RtI monoclonal antibody and flow microfluorometry, we found that IL 4 increased the surface expression of IL 1RtI in a dose-dependent manner. In D10S cells, a subline of the Th2 cell line D10.G4.1, 50-500 pg/ml IL 4 up-regulated the receptor 1.8- to 3.2-fold (p less than 0.05). This up-regulation was also seen at the mRNA level. The effect was not due to increased stability of the mRNA, since IL 4 did not modify the half-life of IL 1RtI mRNA. IL 4 also up-regulated IL 1RtI on CDC25 cells, another Th2 cell line. However, we did not observe an effect of IL 4 on gene expression of IL 1RtI in BALB/c 3T3 fibroblasts. IL 2 and IL 4 showed an additive effect in up-regulating IL 1RtI and D10S cells. These studies indicate that IL 4 up-regulates IL 1RtI in murine Th2 cells by increasing gene expression for IL 1RtI without affecting mRNA stability. Thus, IL 4 production by Th2 cells may amplify the immune response via up-regulation of IL 1RtI.
Cold temperature characterization of ring triplets based on RD53A readout chip (2022)

Abstract This paper reports the Trento test setup and the cold test procedure for three triplets (ID: R4, R5, and R6) assembled with RD53A readout cheap and planar sensors. The trim and tuning of Front Ends (FE), as well as sensor I - V measurements, were made for a cold temperature (−25 °C) for an applied voltage (−30 V for R4, −10 V for R5 and R6). As a part of QC, initially, several test scans: analog, digital, threshold, ToT, noise, etc., were performed to evaluate the module response at −25 °C before applying a necessary tuning script to find a spatially uniform threshold distribution over the pixel matrix. Later, the crosstalk-based disconnected-bump and X-ray scans were made to check modules’ bump bonding quality and hits per pixel. Results reported here show a good agreement to a qualified triplet module, assuring the Trento cold test setup capacity for the ATLAS ITk QA/QC process.
Mechanisms of Selective Leukocyte Recruitment from Whole Blood on Cytokine-Activated Endothelial Cells Under Flow Conditions (1999)

Selective recruitment of eosinophils to sites of allergic and parasitic inflammation involves specific adhesion and activation signals expressed on or presented by stimulated endothelial cells. Here we examined leukocyte recruitment on cytokine-activated HUVEC under flow conditions. We perfused whole blood through a flow chamber to examine mechanisms of selective leukocyte recruitment. Although there was substantial recruitment of leukocytes on TNF-alpha-stimulated HUVEC, we found no selective accumulation of any particular leukocyte subpopulations. In contrast, fewer leukocytes were recruited to IL-4-stimulated HUVEC, but the recruitment was selective for eosinophils. We examined the role of adhesion molecules in these interactions and found that eosinophil recruitment was completely blocked with an alpha4 integrin mAb at the shear rates examined. A significant number of neutrophils were also recruited to IL-4-stimulated HUVEC, and these interactions required P-selectin and P-selectin glycoprotein ligand-1. Thus, whole blood perfusion over cytokine-activated endothelium revealed that IL-4-stimulated HUVEC support selective recruitment of eosinophils, whereas TNF-alpha-stimulated HUVEC lack selectivity for any leukocyte subclass.
Overview of the tertiary Oil Recovery Project (1981)

The Tertiary Oil Recovery Project (TORP) was originally proposed by the University of Kansas as a mechanism by which expertise existing in the areas of petroleum engineering and geology at the university could be brought to bear directly on the problems relating to the declining oil reserve in Kansas, and the Project was established by the Kansas legislature in 1974 for this purpose. TORP was principally established because it was realized that the continued viability of the oil industry in the state would soon be dependent in large measure on implementation of tertiary oil recovery technology. The following specific objectives were established: (1) evaluate potential of tertiary oil recovery processes in Kansas, (2) conduct research/ development on tertiary oil recovery processes applicable in the state; (3) disseminate information about the technology to the Kansas oil industry; (4) interact with oil industry representatives and provide technical assistance on field tests; and (5) educate students in tertiary oil recovery technology.
What Every Business Student Needs to Know About Information Systems (2002)

Whether Information Systems should or should not be part of the core business school curriculum is a recurring discussion in many universities. In this article, a task force of 40 prominent information systems scholars address the issue. They conclude that information systems is absolutely an essential body of knowledge for business school students to acquire as well as a key element of the business school's long-run strategic positioning within the university. Originally prepared in response to draft accreditation guidelines prepared by AACSB International, the article includes a compilation of the concepts that the authors believe to be the core information systems knowledge that all business school students should be familiar with.
Estimate Criteria for Diagnosis and Severity in Benign Prostatic Hyperplasia (1996)

The proposed criteria are valid, practical, and would be useful for the common scale of the BPH severity in clinical and epidemiologic studies.
N-in-1 Retransmission with Network Coding (2010)

Retransmission (ReTX) mechanisms, i.e. Automatic Retransmission reQuest (ARQ) protocols are widely used for error control in mobile communications. Using ARQ, corrupted data frames are retransmitted in several attempts for eventual error recovery at the receiver. Error correction coding and soft combining have also been used in Hybrid ARQ (HARQ) protocols to increase efficiency. However, the evolution of ARQ protocols to date has been limited to the paradigm of ONE ReTX attempt for (the recovery of) ONE data frame, which often leads to excessive redundancies. In this paper we propose a new N-in-1 ReTX scheme. Using Random Network Coding, the scheme further improves the efficiency of ReTX by transforming a data frame into a series of equally-useful blocks for error recovery and sharing every ReTX attempt among multiple frames. Results from extensive simulations show that the proposed scheme achieves a significant throughput gain of up to 106% against the conventional HARQ-CC protocol.
Application of IPv6 for State Grid Corporation Company Smart Grid (2013)

Smart grid must be open, distributed architecture, there are multiple internet, addressable, independently managed entity. Smart grid need to build a data communication network to support the exchange data freely and safely among all the components. The state grid corporation smart grid status and data communication network were described. IPv6 application is internal demand for smart grid construction, and the IPv6 technology applications in the smart grid is important, after that the standard development planning and existing international standards development status were analyzed, and finally the data communication network transition to IPv6 practical work was described. This analysis work for the next generation of internet technology in the smart grid application can be a reference for the smart grid development.
Prevention of NSAID-Induced Ulcers by the Coadministration of Misoprostol: Implications in Clinical Practice (1992)

The guiding principle of ulcer therapy for many years has been "No acid, no ulcer" and many still adhere to it. Nonsteroidal anti-inflammatory drugs (NSAIDs) appear to cause ulcers primarily through prostaglandin depletion rather than through an acid-based mechanism. These ulcers affect a large number of patients and give few warning signs, often none, until it is too late. The profound relief offered to arthritis patients by NSAIDs, in the absence of equally effective remedies, means that rheumatologists must continue to deal with specific and quantifiable risks of NSAID-related gastrointestinal (GI) ulceration and its associated complications. The prostaglandin analog, misoprostol, may address many of these concerns because it reverses the patient's prostaglandin depleted condition. It is effective in preventing NSAID-induced ulcers, and does not interfere with the desired analgesic or anti-inflammatory effects of NSAIDs. The tools to assess the risk of NSAID-related hospitalization or death due to GI complications are available and patients at greatest risk can be identified. Physicians whose patients are at risk may wish to consider therapy with misoprostol 400 to 800 micrograms/day in divided doses. It is recommended that misoprostol be coadministered with the NSAID after meals. The most common side effects that the patient may experience are some mild and transient diarrhea and cramps upon initiation of misoprostol therapy and these can be minimized by taking misoprostol with meals and avoiding magnesium-containing antacids. For misoprostol's protective role to be demonstrated, it should be coprescribed with the NSAID for the duration of the NSAID therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
Electrical characteristics of TiN contacts to N silicon (1981)

We have performed a detailed investigation of TiN contacts on n-type silicon. The barrier height was found to be 0.49±0.01 V and the contact resistivity on 0.001-Ω cm substrates below 10−4 Ω cm2. The TiN layers were produced by reactive sputtering. The resistivity of the layers depends on the partial pressure of N2 in the N2+Ar sputtering gas mixture. A minimum of 55 μΩ cm was obtained, which is below the resistivity of pure Ti films. Finally, we have developed two etching solutions which allow patterning of TiN layers using conventional photolithography techniques.