gebhart/patrepeval huggingface dataset:
Premenopausal antimüllerian hormone concentration is associated with subsequent atherosclerosis (2012)

We report for the first time an inverse relationship between a marker of ovarian reserve (AMH) and subsequent atherosclerosis risk.
High voltage breakdown of solid epoxies at room temperature and in liquid nitrogen (2003)

With the development of high temperature superconductors (HTS) in flexible tape form, work has rapidly moved toward high voltage power applications such as HTS power cables, transformers, and fault current limiters. Generic to the design of these devices is the use of solid dielectric material that can hold off high voltages in combination with either vacuum or liquid nitrogen. Several types of epoxies have been screened by subjecting them to "dunk" tests in liquid nitrogen to determine which materials would not crack after immersion. Materials that survived the dunk tests were further tested for dielectric strength at room temperature and at 77 K. Stycast/sup /spl reg// 2850 FT/24 LV catalyst was found to decrease slightly in strength at 77 K while the Araldite/sup /spl reg// CY 5808/HY 5808 hardener and Stycast/sup /spl reg// 2850 KT/11 catalyst significantly increased. These materials are found to follow a Weibull distribution.
ShardFS vs. IndexFS (2015)

The rapid growth of cloud storage systems calls for fast and scalable namespace processing. While few commercial file systems offer anything better than federating individually non-scalable namespace servers, a recent academic file system, IndexFS, demonstrates scalable namespace processing based on client caching of directory entries and permissions (directory lookup state) with no per-client state in servers. In this paper we explore explicit replication of directory lookup state in all servers as an alternative to caching this information in all clients. Both eliminate most repeated RPCs to different servers in order to resolve hierarchical permission tests. Our realization for server replicated directory lookup state, ShardFS, employs a novel file system specific hybrid optimistic and pessimistic concurrency control favoring single object transactions over distributed transactions. Our experimentation suggests that if directory lookup state mutation is a fixed fraction of operations (strong scaling for metadata), server replication does not scale as well as client caching, but if directory lookup state mutation is proportional to the number of jobs, not the number of processes per job, (weak scaling for metadata), then server replication can scale more linearly than client caching and provide lower 70 percentile response times as well.
Fault Diagnosis for Analog Circuits by Using EEMD, Relative Entropy, and ELM (2016)

This paper presents a novel fault diagnosis method for analog circuits using ensemble empirical mode decomposition (EEMD), relative entropy, and extreme learning machine (ELM). First, nominal and faulty response waveforms of a circuit are measured, respectively, and then are decomposed into intrinsic mode functions (IMFs) with the EEMD method. Second, through comparing the nominal IMFs with the faulty IMFs, kurtosis and relative entropy are calculated for each IMF. Next, a feature vector is obtained for each faulty circuit. Finally, an ELM classifier is trained with these feature vectors for fault diagnosis. Via validating with two benchmark circuits, results show that the proposed method is applicable for analog fault diagnosis with acceptable levels of accuracy and time cost.
Prevention of Experimental Proliferative Vitreoretinopathy With a Biodegradable Intravitreal Implant for the Sustained Release of Fluorouracil (1994)

Intravitreal implantation of biodegradable polymers containing fluorouracil can prevent proliferation of epiretinal membranes resulting in complicated retinal detachment in an animal model of proliferative vitreoretinopathy and indicate their possible usefulness for intravitreal delivery of therapeutic agents.
Restoration of dynamically degraded gray level images in phosphor based display devices (1990)

The concepts of dynamic modulation transfer function (DMTF) and degree of degradation (DD) are used for analyzing gray level image display of a phosphor based display system. Real-time restoration of the motion-degraded display images may be accomplished using one or more inverse filters whose characteristics depend on the magnitude and direction of the motion. Both DMTF and DD characteristics are used in the restoration of motion-degraded images.
Pulse Electrochemical Synthesis of Spherical Hydroxyapatite and Silver Nanoparticles Mediated by the Polymerization of Polypyrrole on Metallic Implants for Biomedical Applications (2015)

Pulse electrochemical deposition is utilized to co-synthesize hydroxyapatite (HA) and silver (Ag) nanoparticles (NPs) with the mediation of polypyrrole (PPy). PPy acts as the core template for HA–NP and chelation agent for Ag–NP formation. The HA-Ag-PPy coatings that contain HA–NPs and Ag–NPs with good osteoconductivity and high antibacterial activity. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Anti-tamper JTAG TAP design enables DRM to JTAG registers and P1687 on-chip instruments (2010)

This paper describes an anti-tamper JTAG Tap design which uses SHA256 secure hash and a true random number generator (TRNG) to create a low gate overhead challenge/response based access system for IC test and on-chip internals. The system may be used to enable 1149.1 TAP instructions or may control access to an IEEE P1687 on-chip instrument. The TAP owner (manufacturer of the IC) may then use DRM (Digital Rights Management) based JTAG software to manage which end users have access to the TAP or TAP accessible areas of the IC.
User-Centric Future Internet and Telecommunication Services (2009)

This paper analyses the current service creation trends in telco and\nWeb worlds, showing how they are converging towards a future Internet of usercentric\nservices embracing typical telco capabilities. The OPUCE platform is\npresented as the next step towards this integrated, user-centric future: a platform\nwhich offers intuitive tools for graphical service creation aimed at individuals\nwith no specific skills in computer science or programming and a serviceoriented\nexecution environment capable of a seamless interoperation of Web\nServices and telco applications based on operator-owned infrastructure. The\nOPUCE platform is compared to existing mashup creation tools to show its\nadvantages and how is compared to existing mashup creation tools to show its\nadvantages and how it could be used to implement a converged and open service\nmarketplace for the Future Internet.
Relationship Between the Results of Sperm Analysis and GIFT (1989)

In vitro fertilization (IVF) and GIFT have been proposed as therapeutic approaches in infertile couples where a significant male factor is present. To date, few published data are available relating the success rate of GIFT to the severity of the male factor. In this report the results of the first 172 GIFT cases were analyzed. The overall pregnancy rate was 18.0%. The relationship between the occurrence of pregnancy and sperm count (millions/ml), total sperm count (millions/ejaculate), % motility, motile sperm count (millions/ml) and total motile sperm count (millions/ejaculate) were examined. Significant direct correlations were observed between the clinical pregnancy rate and sperm count, total sperm count, motile sperm count and total motile sperm count. Motile sperm count and total motile sperm count had the best correlations with clinical pregnancy rates, which were over 24.0% in groups with motile sperm counts exceeding 40 X 10(6) cells/ml or total motile sperm counts greater than 100 X 10(6)/ejaculate. The clinical pregnancy rates were 12.5% and 7.7%, respectively, for groups with motile sperm counts under 10 X 10(6)/ml and total motile sperm counts below 25 X 10(6)/ejaculate. No correlation was found between percent motile cells and pregnancy rate. Results of the sperm penetration assay using zona-free hamster eggs were available in a subpopulation of 27 patients. No significant correlation between this sperm penetration assay and pregnancy rate could be demonstrated. The incidence of chemical pregnancy showed a significant negative correlation with the total motile sperm count, indicating a higher incidence of early pregnancy wastage in cases of oligozoospermia.(ABSTRACT TRUNCATED AT 250 WORDS)
Development of a set of near isogenic and backcross recombinant inbred lines containing most of the Lycopersicon hirsutum genome in a L. esculentum genetic background: a tool for gene mapping and gene discovery. (2000)

A novel population consisted of a set of 99 near isogenic lines (NILs) and backcross recombinant inbred lines (BCRILs) derived from a cross between the cultivated tomato Lycopersicon esculentum cv. E6206 and L. hirsutum accession LA1777 is presented. Most of the lines contain a single defined introgression from L. hirsutum in the L. esculentum genetic background and together, the lines provide a coverage of more than the 85% of the L. hirsutum genome. These lines represent a new tool to uncover the genetic resources hidden in L. hirsutum as well as to study the genes responsible of its unique biology. Furthermore, the study of the allelic frequency and heterozygosity among BCRILs showed that specific genomic regions were likely subjected to unintentional selection pressures during the stock development. Genes involved in the reproductive behavior and (or) pollen viability are hypothesized to be responsible for these alterations.
Quantification of tumor mobility during the breathing cycle using 3D dynamic MRI (2006)

Respiration causes movement and shape changes in thoracic tumors, which has a direct influence on the radio-therapy planning process. Current methods for the estimation of tumor mobility are either two-dimensional (fluoroscopy, 2D dynamic MRI) or based on radiation (3D (+t) CT, implanted gold markers). With current advances in dynamic MRI acquisition, 3D+t image sequences of the thorax can be acquired covering the thorax over the whole breathing cycle. In this work, methods are presented for the interactive segmentation of tumors in dynamic images, the calculation of tumor trajectories, dynamic tumor volumetry and dynamic tumor rotation/deformation based on 3D dynamic MRI. For volumetry calculation, a set of 21 related partial volume correcting volumetry algorithms has been evaluated based on tumor surrogates. Conventional volumetry based on voxel counting yielded a root mean square error of 29% compared to a root mean square error of 11% achieved by the algorithm performing best among the different volumetry methods. The new workflow has been applied to a set of 26 patients. Preliminary results indicate, that 3D dynamic MRI reveals important aspects of tumor behavior during the breathing cycle. This might imply the possibility to further improve high-precision radiotherapy techniques.
Supplemental Data from MACC1 Induces Tumor Progression in Transgenic Mice and Colorectal Cancer Patients via Increased Pluripotency Markers Nanog and Oct4 (2023)

&lt;p&gt;Material and Methods Table 1. Primers for genotyping vil-MACC1 mice Table 2. Primers for qRT-PCR Table 3. Primers for ChIP Table 4. The 50 most upregulated genes when comparing Apc vs vil-MACC1/ApcMin mice Table 5. The 50 most downregulated genes when comparing Apc vs vil-MACC1/ApcMin mice Supplementary Figure legends.&lt;/p&gt;
Small inductive current switching with high-voltage vacuum circuit breakers (2021)

Circuit breakers are appropriate devices to energize and de-energize electrical circuits. The requirements for standard switching applications are typically covered by the standards of the International Electrical Commission (e.g. IEC 62271-100 and IEC 62271-1). Switching of small inductive currents are not automatically qualified by type tests in accordance to IEC 62271-100 and -1. The range of requirements for these applications is extremely wide, ranging from switching of unloaded transformers to the high currents of tertiary winding applications at power transformers. Gas circuit breakers are the present solution to cover high-voltage applications for these inductive loads. Circuit breakers with a point-on-wave switching device for the individual poles are used to operate the circuit breaker in the reignition-free time window to ensure a safe and sustainable operation. The increased application of vacuum circuit breakers (VCB) in high-voltage systems creates the need for technology that also covers these requirements.This paper explores the usage of a three-pole operated high-voltage vacuum circuit breaker (one drive for three poles) in combination with a filter circuit. We determine that it is a suitable combination to avoid switching overvoltages and internal winding resonance overvoltages when small inductive loads are de-energized.The approach is to simulate the circuits with an electromagnetic transient program with high-frequency models of the relevant grid components to evaluate appropriate dimensions and locations for RC filter circuits. This simulation study determines the optimized parameters for the filter circuits and then verifies the results by means of simulation of breaking operations with a vacuum circuit breaker model. The methodology is based on the long-term experience in the medium voltage range and can also be applied to the high-voltage applications. On this basis also the acceptance criteria are derived from medium voltage know-how.
Detection of Fentanyl Analogs and Synthetic Opioids in Real Hair Samples (2018)

Novel synthetic opioids include various analogs of fentanyl and emerging non-fentanyl compounds with different chemical structures, such as AH-7921, MT-45 and U-47700. In recent years, these drugs have rapidly emerged on the drug market, and their abuse has been increasing worldwide. The motivations for use of these new compounds include their legal status, ready availability, low cost, users' curiosity or preference for their particular pharmacological properties and the intention to avoid detection. Furthermore, more common drugs like heroin are now increasingly being replaced or cut with fentanyl or new designer opioids; thus, many drug users are unintentionally or unknowingly using synthetic fentanyl analogs. In this scenario, the detection of new psychoactive substances in hair can provide insight into their current diffusion among the population and social characteristics of these synthetic drug users. In this manuscript, we describe a simple, fast, specific and sensitive UHPLC-MS-MS method able to detect 13 synthetic opioids (including fentanyl analogs) and metabolites in hair samples. Furthermore, the method includes the detection of 4-anilino-N-phenethyl-piperidine (4-ANPP), which is considered both a precursor and a metabolite of several fentanyl analogs. The method was applied to 34 real hair samples collected in New York City from subjects who had reported past-year non-medical opioid and/or heroin use. In total, 17 samples tested positive for at least one target analyte, with oxycodone (nine samples) and tramadol (eight samples) being the most common. Among these, the method was able to quantify furanyl-fentanyl and fentanyl in the pg/mg range in two samples. Simultaneously, also 4-ANPP was detected, giving evidence for the first time that this compound can be selected as a marker of fentanyl analogs use via hair testing. In conclusion, this study confirmed the increasing diffusion of new synthetic opioids and "fentalogs" with high potency among non-medical opioid users.
ROCK inhibitors in ocular disease (2016)

&lt;p class="ADMETabstracttext"&gt;Rho kinases (ROCKs) have a crucial role in actin-cytoskeletal reorganization and thus are involved in broad aspects of cell motility, from smooth muscle contraction to neurite outgrowth. The first marketed ROCK inhibitor, called fasudil, has been used safely for treatment of cerebral vasospasm since 1995 in Japan. During the succeeding decades ROCK inhibitors have been applied in many pathological conditions from central nervous system disorders to cardiovascular disease as potential therapeutic agents or experimental tools to help understand the underlying (patho)mechanisms. In 2014, a fasudil derivate named ripasudil was accepted for clinical use in glaucoma and ocular hypertension. Since ROCK kinases are widely expressed in ocular tissues, they have been implicated in the pathology of many ocular conditions such as corneal dysfunction, glaucoma, cataract, diabetic retinopathy, age-related macular degeneration, and retinal detachment. This paper aims to provide an overview of the most recent status/application of ROCK inhibitors in the field of eye disease.&lt;/p&gt;
Fully automated grey and white matter spinal cord segmentation (2016)

Axonal loss in the spinal cord is one of the main contributing factors to irreversible clinical disability in multiple sclerosis (MS). In vivo axonal loss can be assessed indirectly by estimating a reduction in the cervical cross-sectional area (CSA) of the spinal cord over time, which is indicative of spinal cord atrophy, and such a measure may be obtained by means of image segmentation using magnetic resonance imaging (MRI). In this work, we propose a new fully automated spinal cord segmentation technique that incorporates two different multi-atlas segmentation propagation and fusion techniques: The Optimized PatchMatch Label fusion (OPAL) algorithm for localising and approximately segmenting the spinal cord, and the Similarity and Truth Estimation for Propagated Segmentations (STEPS) algorithm for segmenting white and grey matter simultaneously. In a retrospective analysis of MRI data, the proposed method facilitated CSA measurements with accuracy equivalent to the inter-rater variability, with a Dice score (DSC) of 0.967 at C2/C3 level. The segmentation performance for grey matter at C2/C3 level was close to inter-rater variability, reaching an accuracy (DSC) of 0.826 for healthy subjects and 0.835 people with clinically isolated syndrome MS.
Comparative evaluation of 6kV Si and SiC power devices for medium voltage power electronics applications (2015)

In order to better assist researchers to select the appropriate power device for medium voltage power electronics applications, this paper presents a comparative evaluation on three typical 6kV level Si and SiC power devices, including 6.5kV/25A Si IGBT from ABB, 6.5kV/15A normally off SiC JFET from USCi and a FREEDM System Center developed 6kV/26A SiC series-connected JFET. The 6.5kV Si IGBT and 6.5kV SiC JFET are packaged in the same module to minimize the effect of different parasitic inductance on the comparison. The 6kV SiC series-connected JFET is developed based on one 1.2kV SiC MOSFET from Cree and four 1.2kV SiC JFETs from Infineon, in this paper, named FREEDM Super-Cascode. A short introduction on the three selected devices are first given, then their forward conduction and switching performances are compared. Also, some additional features are discussed and compared, including the device size, cost, gate driver circuit complexity.
Multifunctional Six-Phase Motor Drives with Algorithms of Synchronized PWM (2006)

Novel methodology of synchronized pulsewidth modulation (PWM) has been disseminated for control of six-phase (dual-three phase) induction machine drives fed by two three-phase inverters with both single and separate DC voltage sources. Control algorithms are based in this case on the 30deg-phase-shifting of control and output signals of two standard voltage source inverters. Four basic schemes of synchronized PWM, applied for control of six-phase drives, have been analyzed and compared. Simulations results are given for continuous, discontinuous and combined versions of synchronized PWM. The spectra of the phase voltage of the six-phase drives with algorithms of synchronized PWM do not contain even harmonics and sub-harmonics, which is especially important for the high power/current applications
Single-crystal Pb[(Zn/sub 1/3/Nb/sub 2/3/)/sub 0.93/Ti/sub 0.07/]O/sub 3/ (PZNT 93/7) for highly reliable ultrasonic transducers (2003)

Piezoelectric single crystals of Pb[(Zn/sub 1/3/Nb/sub 2/3/)/sub 0.93/Ti/sub 0.07/]O/sub 3/ (PZNT 93/7) 40 mm in diameter were grown with PbO flux by the solution Bridgman method. The prerequisites for the growth of PZNT 93/7 single crystals are higher melting temperature, a longer melting time than Pb[(Zn/sub 1/3/Nb/sub 2/3/)/sub 0.91/Ti/sub 0.09/]O/sub 3/ (PZNT 91/9), and the addition of ZnO. The pyrochlore pellets of PZNT 93/7 are more stable than those of PZNT 91/9. The Curie temperature is 155-175/spl deg/C and the temperature corresponds to the rhombohedral-tetragonal phase change, T/sub rt/, is higher than 100/spl deg/C for PZNT 93/7 single crystals. T/sub rt/ corresponds to the degradation boundary temperature of the electromechanical coupling coefficient, k/sub 33/, and also of the dielectric constant. The sensitivity degradation of ultrasonic transducers using PZNT 93/7 single crystals can be avoided up to a high temperature of about 100/spl deg/C. Although the piezoelectric properties of single crystals of PZNT 91/9 are excellent, it has become clear that the electromechanical coupling coefficient, k/sub 33/, and other properties degrade drastically above about 80/spl deg/C. Therefore, our results indicate that PZNT 93/7 has good potential for application in the mass production of ultrasonic transducers.
Intracellular Distribution of Oligonucleotides Delivered by Cationic Liposomes: Light and Electron Microscopic Study1 (1997)

Synthesized oligonucleotides are used in anti-sense and anti-gene technology to control gene expression. Because cells do not easily take up oligonucleotides, cationic liposomes have been employed to facilitate their transport into cells. Although cationic liposomes have been used in this way for several years, the precise mechanisms of the delivery of oligonucleotides into cells are not known. Because no earlier reports have been published on the liposomal delivery of oligonucleotides at the ultrastructural level, we performed a study, using electron microscopy, on the cellular uptake and intracellular distribution of liposomal digoxigenin-labeled oligodeoxynucleotides (ODNs) at several concentrations (0.1, 0.2, an 1.0 microM) in CaSki cells. Two cationic lipids (10 microM) were compared for transport efficiency: polycationic 2,3-dioleoyloxy-N-[2(sperminecarboxamido)ethyl]-N,N-dimethyl -1-propanaminium trifluoroacetate (DOSPA) and monocationic dimethyl-dioctadecylammonium bromide (DDAB). Both liposomes contained dioleoyl-phosphatidylethanolamine (DOPE) as a helper lipid. Endocytosis was found to be the main pathway of cellular uptake of liposomal ODNs. After release from intracellular vesicles, ODNs were carried into the perinuclear area. The nuclear membrane was found to be a barrier against the penetration of ODNs delivered by liposomes into the nucleus. Release from vesicles and transport into the nuclear area was faster when the oligo-DDAB/DOPE complex had a positive net charge (0.1 and 0.2 microM ODN concentrations), and only under this condition were some ODNs found in nucleoplasm. Although DOSPA/DOPE could also efficiently deliver ODNs into the cytosol, no ODNs were found in nucleoplasm. These findings suggest that both the type of liposome and the charge of the oligo-liposome complex are important for determination of the intracellular distribution of ODNs.