gebhart/patrepeval huggingface dataset:
Envisioning future cognitive telerehabilitation technologies: a co-design process with clinicians (2016)

Purpose Cognitive telerehabilitation is the concept of delivering cognitive assessment, feedback, or therapeutic intervention at a distance through technology. With the increase of mobile devices, wearable sensors, and novel human-computer interfaces, new possibilities are emerging to expand the cognitive telerehabilitation paradigm. This research aims to: (1) explore design opportunities and considerations when applying emergent pervasive computing technologies to cognitive telerehabilitation and (2) develop a generative co-design process for use with rehabilitation clinicians. Methods We conducted a custom co-design process that used design cards, probes, and design sessions with traumatic brain injury (TBI) clinicians. All field notes and transcripts were analyzed qualitatively. Results Potential opportunities for TBI cognitive telerehabilitation exist in the areas of communication competency, executive functioning, emotional regulation, energy management, assessment, and skill training. Designers of TBI cognitive telerehabilitation technologies should consider how technologies are adapted to a patient's physical/cognitive/emotional state, their changing rehabilitation trajectory, and their surrounding life context (e.g. social considerations). Clinicians were receptive to our co-design approach. Conclusion Pervasive computing offers new opportunities for life-situated cognitive telerehabilitation. Convivial design methods, such as this co-design process, are a helpful way to explore new design opportunities and an important space for further methodological development. Implications for Rehabilitation Designers of rehabilitation technologies should consider how to extend current design methods in order to facilitate the creative contribution of rehabilitation stakeholders. This co-design approach enables a fuller participation from rehabilitation clinicians at the front-end of design. Pervasive computing has the potential to: extend the duration and intensity of cognitive telerehabilitation training (including the delivery of 'booster' sessions or maintenance therapies); provide assessment and treatment in the context of a traumatic brain injury (TBI) patient's everyday life (thereby enhancing generalization); and permit time-sensitive interventions. Long-term use of pervasive computing for TBI cognitive telerehabilitation should take into account a patient's changing recovery trajectory, their meaningful goals, and their journey from loss to redefinition.
Chilenopeptins A and B, Peptaibols from the Chilean Sepedonium aff. chalcipori KSH 883 (2016)

The Chilean Sepedonium aff. chalcipori strain KSH 883, isolated from the endemic Boletus loyo Philippi, was studied in a polythetic approach based on chemical, molecular, and biological data. A taxonomic study of the strain using molecular data of the ITS, EF1-α, and RPB2 barcoding genes confirmed the position of the isolated strain within the S. chalcipori clade, but also suggested the separation of this clade into three different species. Two new linear 15-residue peptaibols, named chilenopeptins A (1) and B (2), together with the known peptaibols tylopeptins A (3) and B (4) were isolated from the semisolid culture of strain KSH 883. The structures of 1 and 2 were elucidated on the basis of HRESIMS(n) experiments in conjunction with comprehensive 1D and 2D NMR analysis. Thus, the sequence of chilenopeptin A (1) was identified as Ac-Aib(1)-Ser(2)-Trp(3)-Aib(4)-Pro(5)-Leu(6)-Aib(7)-Aib(8)-Gln(9)-Aib(10)-Aib(11)-Gln(12)-Aib(13)-Leu(14)-Pheol(15), while chilenopeptin B (2) differs from 1 by the replacement of Trp(3) by Phe(3). Additionally, the total synthesis of 1 and 2 was accomplished by a solid-phase approach, confirming the absolute configuration of all chiral amino acids as l. Both the chilenopeptins (1 and 2) and tylopeptins (3 and 4) were evaluated for their potential to inhibit the growth of phytopathogenic organisms.
Will novel oral formulations change the management of inflammatory bowel disease? (2016)

A new avenue using easily administered oral therapies for the management of IBD is being introduced. While their place in the clinical armamentarium remains to be proven, it is likely that many of these drugs will find their place in the treatment algorithm of IBD in the next few years. Thus, we will face times in which IBD therapy will be based on significantly more tablets than prescribed today.
Notch Ligand Delta-Like 1 Is Associated With Loss of Vascular Endothelial Barrier Function (2021)

Vascular leakage associated with vascular endothelial cell (vEC) dysfunction is a hallmark of sepsis. Causative for the decreased integrity of the vascular endothelium (vE) is a complex concurrence of pathogen components, inflammation-associated host factors, and the interaction of vECs and activated circulating immune cells. One signaling pathway that regulates the integrity of the vE is the Notch cascade, which is activated through the binding of a Notch ligand to its respective Notch receptor. Recently, we showed that the soluble form of the Notch ligand Delta-like1 (sDLL1) is highly abundant in the blood of patients with sepsis. However, a direct connection between DLL1-activated Notch signaling and loss of vEC barrier function has not been addressed so far. To study the impact of infection-associated sDLL1, we used human umbilical vein cells (HUVEC) grown in a transwell system and cocultured with blood. Stimulation with sDLL1 induced activation as well as loss of endothelial tight structure and barrier function. Moreover, LPS-stimulated HUVEC activation and increase in endothelial cell permeability could be significantly decreased by blocking DLL1-receptor binding and Notch signaling, confirming the involvement of the cascade in LPS-mediated endothelial dysfunction. In conclusion, our results suggest that during bacterial infection and LPS recognition, DLL1-activated Notch signaling is associated with vascular permeability. This finding might be of clinical relevance in terms of preventing vascular leakage and the severity of sepsis.
Application of Modified Vacuum Assisted Closure with Silver Materials in Chronic Infected Wound (2008)

Purpose: Chronic infected wounds sustained over 4 weeks with exposed tendon or bone are difficult challenges to plastic surgeons. Vacuum assisted closure (VAC) device has been well used for the management of chronic wounds diminishing wound edema, reducing bacterial colonization, promoting formation of granulation tissue and local blood flow by negative pressure to wounds. But Commercial ready-made VAC device might have some difficulties to use because of its high expenses and heavy weight. So we modified traditional VAC device with silver dressing materials as topical therapeutic agents for control of superimposed bacterial wound infection such as MRSA, MRSE and peudomonas. Methods: We designed the modified VAC device using wall suction, 400 cc Hemovac and combined slow release silver dressing materials. We compared 5 consecutive patients' data treated by commercial ready-made VAC device(Group A) with 11 consecutive patients' data treated by modified VAC device combined with silver dressing materials(group B) from September 2004 to June 2007. Granulation tissue growth, wound discharge, wound culture and wound dressing expenses were compared between the two groups. Received November 29, 2007 Revised April 2, 2008 Accepted April 28, 2008 Address Correspondence: Jae Ho Jeong, M.D., Ph.D., Department of Plastic and Reconstructive Surgery, College of Medicine, Yeungnam University Hospital, 317-1 Daemyung 5-dong, Nam-gu, Daegu 705-717, Korea. Tel: 053)620-3481/ Fax: 053)626-0705/E-mail: jhjeong@med.yu.ac.kr *본 논문은 2005년 제 58차 대한성형외과학회 학술대회에서 포스터 발표되었음. Results: In comparison of results, no statistical differences were identified in reducing rate of wound size between group A and B. Wound discharge was significantly decreased in both groups. Modified VAC device with silver dressing materials showed advantages of convenience, cost effectiveness and bacterial reversion. Conclusion: In combination of modified VAC device and silver dressing materials, our results demonstrated the usefulness of managing chronic open wounds superimposed bacterial infection, cost effectiveness compared with traditional VAC device and improvement of patient mobility.
Pre- and Postoperative Circulating IGF-I, IGFBP-3, and IGFBP-7 Levels in Relation to Endocrine Treatment and Breast Cancer Recurrence: A Nested Case-Control Study (2021)

Insulin-like growth factor-I (IGF-I) and its binding proteins (BPs) have been associated with breast cancer risk, especially high IGF-I concentrations and the biologically active fraction estimated as the IGF-I/IGFBP-3 molar ratio. The relation of circulating IGF-I and IGFBP-3 concentrations with risk of breast cancer recurrence has been less documented. In addition a new member to a sub-group of the IGFBP-superfamily was recently identified, the low affinity IGFBP-7. To date, the role of systemic IGFBP-7 in breast cancer progression has not been investigated. Our purpose was to establish whether circulating IGF-I, IGFBP-3, and IGFBP-7 levels are related to recurrence-risk in breast cancer. A case-control study was nested within the population-based BCBlood cohort of 853 breast cancer patients diagnosed 2002-2010 in Sweden and followed through 2012. In total, 95 patients with recurrence and 170 controls were matched on age and tumor characteristics. Plasma IGF analytes and tumor membrane IGF-I receptor (IGF-IR<sup>m</sup>) positivity were analyzed and recurrence-risk was evaluated with conditional logistic regression. Preoperative tertiles of IGF-I and IGFBP-3 were both positively associated with recurrence-risk, but not IGFBP-7. The trend was of borderline significance for IGF-I, T1:REF, T2 OR:1.6, T3 OR: 2.2 adjusted <i>P</i> <sub>trend</sub>=0.057 and significant for IGFBP-3 T1:REF, T2 OR:1.2, T3 OR: 2.1 adjusted <i>P</i> <sub>trend</sub>=0.042. The models were adjusted for age, anthropometric factors, smoking, and treatments. There was a significant interaction between IGFBP-7 and IGF-IR<sup>m</sup> positivity on recurrence, where the highest IGFBP-7 highest IGFBP-7 tertile conferred increased recurrence-risk in patients with IGF-IR<sup>m</sup> positive tumors but not in those with IGF-IR<sup>m</sup> negative tumors (<i>P</i> <sub>interaction</sub>=0.024). By the 1-year visit, age-adjusted IGF-I levels were reduced by 17% while IGFBP-3 and IGFBP-7 were stable. IGF-I levels were significantly reduced by radiotherapy in all patients and by tamoxifen in patients with ER<sup>+</sup> tumors. Postoperative changes >10% (n=208) in IGF-I, IGFBP-3, IGFBP-7, or the IGF-I/IGFBP-3 ratio did not predict recurrence after adjustment for preoperative levels, age, anthropometric factors, smoking, and treatments. In conclusion, this study suggests that preoperative IGF-I and IGFBP-3 levels, but not postoperative changes, might provide independent prognostic information and influence breast cancer recurrence. The role of IGFBP-7 in breast cancer merits further study.
ChemInform Abstract: A Concise Synthesis of Piperazine‐2‐carboxylic Acids via β‐Lactam‐ Derived α‐Amino Acid N‐Carboxy Anhydrides. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Vessel extraction in medical images by wave-propagation and traceback (2001)

This paper presents an approach for the extraction of vasculature from angiography images by using a wave propagation and traceback mechanism. We discuss both the theory and the implementation of the approach. Using a dual-sigmoidal filter, we label each pixel in an angiogram with the likelihood that it is within a vessel. Representing the reciprocal of this likelihood image as an array of refractive indexes, we propagate a digital wave through the image from the base of the vascular tree. This wave "washes" over the vasculature, ignoring local noise perturbations. The extraction of the vasculature becomes that of tracing the wave along the local normals to the waveform. While the approach is inherently single instruction stream multiple data stream (SIMD), we present an efficient sequential algorithm for the wave propagation and discuss the traceback algorithm. We demonstrate the effectiveness of our integer image neighborhood-based algorithm and its robustness to image noise.
Transobturator surgery for female stress incontinence: a comparative anatomical study of outside‐in vs inside‐out techniques (2007)

OBJECTIVE To assess the specific risks of injury to neural and vascular structures inherent in two approaches to transobturator surgery for inserting a suburethral sling, i.e. the outside-in (standard technique) and inside-out approaches. MATERIALS AND METHODS The study comprised seven cadavers, providing 14 obturator regions. Five specimens had a tape inserted outside-in on one side, and inside-out on the other; of the remaining two cadavers, one had an inside-out tape and one an outside-in tape, bilaterally. After tape insertion, the cadavers were dissected. Particular attention was paid to the distances between the tape and the deep external pudendal vessels, and between the tape and the posterior branch of the obturator nerve. RESULTS With the inside-out technique, the safety margins were reduced, and the external pudendal vessels and the posterior branch of the obturator nerve were at greater risk of injury. CONCLUSION The two techniques are not equivalent, with a lower risk of injury to vascular and nerve structures with the outside-in technique.
Differences in the Quantity of DNA Found in the Urine and Saliva of Smokers Versus Nonsmokers: Implications for the Timing of Epigenetic Events (2012)

TP53 is a tumor-suppressor gene coding for p53, a protein responsible for cell-cycle arrest and DNA repair. Smoking has been demonstrated to lead to the methylation of tumor-suppressor genes in noncancerous lung biopsy tissues of smokers, and in bodily fluids, promoter hypermethylation occurs very early in the progression of cancer. Thus, DNA methylation changes may be initiated long before cells become cancerous. As this association has never been explored in young, healthy individuals, we decided to look at DNA isolated from urine and saliva samples taken from young male and female smoking and nonsmoking participants. While p53 methylation was not found in any of the samples tested, differences in DNA concentration between the two groups may shed light on the timing of epigenetic alterations, as well as better explain why the negative impact of smoking is not often found in young, healthy adults.
When more is less: Emergent suppressive interactions in three-drug combinations (2017)

We find a surprising number of suppressive interactions in higher-order drug combinations. Without examining lower-order (pairwise) bacterial growth, emergent suppressive effects would be missed, potentially affecting our understanding of evolution of resistance and treatment strategies for resistant pathogens. These findings suggest that careful examination of the full factorial of drug combinations is needed to uncover suppressive interactions in higher-order combinations.
Abnormal Signal Detection based on Time Series Clustering (2019)

Abnormal signals are extremely important to almost every area including industry, medical and transportation. However, the various huge quantity signals make signal detection applying to every condition a challenging problem.
Structure and Evolution of the hAT Transposon Superfamily (2001)

The maize transposon Activator (Ac) was the first mobile DNA element to be discovered. Since then, other elements were found that share similarity to Ac, suggesting that it belongs to a transposon superfamily named hAT after hobo from Drosophila, Ac from maize, and Tam3 from snapdragon. We addressed the structure and evolution of hAT elements by developing new tools for transposon mining and searching the public sequence databases for the hallmarks of hAT elements, namely the transposase and short terminal inverted repeats (TIRs) flanked by 8-bp host duplications. We found 147 hAT-related sequences in plants, animals, and fungi. Six conserved blocks could be identified in the transposase of most hAT elements. A total of 41 hAT sequences were flanked by TIRs and 8-bp host duplications and, out of these, 34 sequences had TIRs similar to the consensus determined in this work, suggesting that they are active or recently active transposons. Phylogenetic analysis and clustering of hAT sequences suggest that the hAT superfamily is very ancient, probably predating the plant-fungi-animal separation, and that, unlike previously proposed, there is no evidence that horizontal gene transfer was involved in the evolution of hAT elements.
Inhibition of ovulation by administration of estetrol in combination with drospirenone or levonorgestrel: Results of a phase II dose-finding pilot study (2015)

Combined with a progestin, E4 adequately suppresses ovarian activity, particularly when given at a dosage above 10 mg/day.
Numerical Simulation of Blood Flow in a Vessel by Using COMSOL Multiphysics® Software (2020)

Dynamics of the blood flow play an important role in the development and treatment of cardiovascular diseases. In recent decades, blood flow simulation has been widely used to better understand the symptomatic spectrum of different diseases, in order to improve existing or develop new therapeutic techniques. Numerical simulation for biomagnetic fluid (such as blood) flow through a tube with rectangular cross section under the influence of magnetic field is studied in this work. Blood considered as a magnetic and incompressible fluid. The magnetic field effects on the blood stream in a tube are created by a permanent magnet outside the tube. The equations of motion which describe the flow is governed by the combination of magnetic equations for permanent magnet and Navier-Stokes equation for fluid (blood) were solved numerically by using COMSOL Multiphysics® Modeling Software.
Three-dimensional foam-type current collectors for rechargeable batteries: A short review (2021)

Energy storage systems as lithium-ion batteries (LIBs) have become an essential part of our lives, powering on-the-go technologies we use every day. Until recently, immense attention was paid to designing and synthesizing advanced active materials for LIBs to enhance the battery characteristics. However, not the least crucial part of the battery, the current collector, was left unattended for a long time. Therefore, it is not surprising that the batteries reached their limits in power and energy densities, leaving the battery progress equal to an almost flat line. The only way to go ahead with the battery technology would be to design new architectures or to investigate new materials. Changing the battery current collector from planar to three-dimensional (3D) would offer dimensionality to the electrodes meaning short diffusion length for Li-ions, which will boost power density, more active material, and mechanical stability. Herein, in this review, various 3D architecture current collectors will be summarized, and recent advances in synthesis routes will be discussed to point out the importance of 3D structures. In addition, the correlation between the electrochemical performances of batteries and current collector architecture will be reviewed. More than 50 research publications related to the synthesis and performance of different 3D current collectors were reviewed and compared. The review results suggest that despite the outstanding performance, currently used technologies to obtain 3D current collectors make them unacceptable in the commercial sphere, and cheaper, faster and simple synthesis routes are desired to be explored.
International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: Proposed Diagnostic Criteria for Chronic GVHD (Part I) (2013)

The International Chronic Ocular GVHD Consensus Group held 4 working meetings to define new diagnostic metrics for chronic ocular graft-versus-host disease (GVHD). After considering the factors currently used to diagnose chronic ocular GVHD, the Consensus Group identified 4 subjective and objective variables to measure in patients following allogeneic hematopoietic stem cell transplantation (HSCT): OSDI, Schirmer's score without anesthesia, corneal staining, and conjunctival injection. Each variable was scored 0-2 or 0-3, with a maximum composite score of 11. Consideration was also given to the presence or the absence of systemic GVHD. On the basis of their composite score and the presence or absence of systemic GVHD, patients were assigned to one of three diagnostic categories: NO, PROBABLE, or DEFINITE ocular GVHD. New diagnostic criteria for chronic ocular GVHD are presented by the Consensus Group. Validation studies are needed to identify the best combination of the proposed metrics to maximize diagnostic sensitivity and specificity.
RESTRICTION ENDONUCLEASE ANALYSIS OF DNA FROM THE STREPTOMYCES PHAGES SH3, SH5, SH10 AND SH13 (1981)

Conference Abstract| April 01 1981 RESTRICTION ENDONUCLEASE ANALYSIS OF DNA FROM THE STREPTOMYCES PHAGES SH3, SH5, SH10 AND SH13 Friedrich Walter; Friedrich Walter 1Akademie der Wissenschaften der DDR, Ferschungszentrum für Molekularbiologie und Medizin, Zentralinstitut für Mikrobiologie und experimentelle Therapie, DDR-69 Jena, Beutenbergstr. 11, G.D.R. Search for other works by this author on: This Site PubMed Google Scholar Manfred Hartmann; Manfred Hartmann 1Akademie der Wissenschaften der DDR, Ferschungszentrum für Molekularbiologie und Medizin, Zentralinstitut für Mikrobiologie und experimentelle Therapie, DDR-69 Jena, Beutenbergstr. 11, G.D.R. Search for other works by this author on: This Site PubMed Google Scholar Siegfried Klaus Siegfried Klaus 1Akademie der Wissenschaften der DDR, Ferschungszentrum für Molekularbiologie und Medizin, Zentralinstitut für Mikrobiologie und experimentelle Therapie, DDR-69 Jena, Beutenbergstr. 11, G.D.R. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1981) 9 (2): 295P. https://doi.org/10.1042/bst009295p Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Friedrich Walter, Manfred Hartmann, Siegfried Klaus; RESTRICTION ENDONUCLEASE ANALYSIS OF DNA FROM THE STREPTOMYCES PHAGES SH3, SH5, SH10 AND SH13. Biochem Soc Trans 1 April 1981; 9 (2): 295P. doi: https://doi.org/10.1042/bst009295p Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1981 Biochemical Society1981 Article PDF first page preview Close Modal You do not currently have access to this content.
A TSV-based architecture for AC-DC converters (2013)

In this paper, a proposed through silicon via (TSV) structure is used to construct AC-DC converters. This structure is analyzed using 3D electromagnetic full-wave simulators. The results show that the proposed 3D converter exhibits small area with superior performance compared to a 2D transformer, for the same footprint as lossy substrate effects are neglected for low frequency range of interest for DC converters.