gebhart/patrepeval huggingface dataset:
Sample-to-answer acoustic detection of DNA in complex samples (2017)

The present study demonstrates the sensitive and label-free acoustic detection of dsDNA amplicons produced from whole Salmonella Thyphimurium cells without employing any DNA extraction and/or purification step, in the presence of the lysed bacterial cells and in a hybridization-free assay. A sample-to-answer assay is also shown during DNA detection directly in milk.
Effect of Pre‐test Genetic Counseling for Deaf Adults on Knowledge of Genetic Testing (2011)

Empirical data on genetic counseling outcomes in the deaf population are needed to better serve this population. This study was an examination of genetics knowledge before and after culturally and linguistically appropriate pre-test genetic counseling in a diverse deaf adult sample. Individuals ≥18 years old with early-onset sensorineural deafness were offered connexin-26/30 testing and genetic counseling. Participants completed questionnaires containing 10 genetics knowledge items at baseline and following pre-test genetic counseling. The effects of genetic counseling, prior beliefs about etiology, and participant's preferred language on genetics knowledge scores were assessed (n = 244). Pre-test genetic counseling (p = .0007), language (p < .0001), prior beliefs (p < .0001), and the interaction between counseling and beliefs (p = .035) were predictors of genetics knowledge. American Sign Language (ASL)-users and participants with "non-genetic/unknown" prior beliefs had lower knowledge scores than English-users and participants with "genetic" prior beliefs, respectively. Genetics knowledge improved after genetic counseling regardless of participants' language; knowledge change was greater for the "non-genetic/unknown" beliefs group than the "genetic" beliefs group. ASL-users' lower knowledge scores are consistent with evidence that ethnic and cultural minority groups have less genetics knowledge, perhaps from exposure and access disparities. Culturally and linguistically appropriate pre-test genetic counseling significantly improved deaf individuals' genetics knowledge. Assessing deaf individuals' prior beliefs is important for enhancing genetics knowledge.
Miniaturizing Ultrastable Electromagnetic Oscillators: Sub-10−14 Frequency Instability from a Centimeter-Scale Fabry-Perot Cavity (2022)

The best performance from compact, portable, and repeatably manufactured electromagnetic (EM) oscillators has for decades been built upon crystalline quartz resonators operating at radio frequencies. Such a source of frequency-stable EM waves has enabled a wide range of applications of significant technical and societal benefit, such as navigation and communication systems, distributed sensing, geodesy, and fundamental physics. However, meeting demands for increased measurement sensitivity requires pushing beyond a fractional frequency stability of ${10}^{\ensuremath{-}13}$, typical of the best ovenized quartz. To date, such performance has been available in the microwave domain only with the use of complex cryogenic systems, or in the optical domain at the expense of larger volume and weight. In either case, the size, weight, and power of state-of-the-art EM oscillators has relegated their use to laboratory experiments. Here we demonstrate the validity of a manufacturable, compact Fabry-Perot reference that improves upon all other centimeter-scale oscillators by more than a factor of 10, including those based on solid-state optical resonators as well as quartz. In a specific implementation, we show an 8 ml bonded assembly containing three vacuum-gap Fabry-Perot optical cavities with mirrors lithographically fabricated on a single substrate, each with quality factor exceeding 10 billion. A laser stabilized to one of the cavities exhibits thermal-noise-limited phase noise for offset frequencies ranging from 1 Hz to nearly 1 kHz, and fractional frequency stability of $7\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}15}$ at 1 s. Our advance with lithographically defined and microfabricated mirrors is validated by rigorous models, which highlight a path to oscillators with size comparable to ovenized quartz, but with significantly improved performance. For example, we predict sub-${10}^{\ensuremath{-}14}$ performance is readily attainable with a Fabry-Perot cavity volume less than 2 ml.
Presence of Aldose Reductase Inhibitors in Tea Leaves (2001)

Water extract from commercial English tea has a potent inhibitory activity against human placenta aldose reductase (NADPH oxidoreductase, E.C.1.1.1.21.). Inhibitory activity was separated into five major fractions by one-step chromatography with a C-18 reverse phase column. The most active fraction was further subjected to reverse phase column chromatography. As a result, a well-known flavone-glycoside, isoquercitrin, was isolated as the most potent chemical. The inhibitory character of isoquercitrin for aldose reductase was a mix of uncompetitive and noncompetitive inhibitions, and its IC50 was 1 x 10(-6) M. In rat sciatic nerve tissue preparations, sorbitol accumulation in the presence of high concentrations of glucose (30 mM) was inhibited by 38% at 5 x 10(-4) M of isoquercitrin. The flavone-glycoside isoquercitrin is the active inhibitor of aldose reductase inhibitor present in English tea. Given the ability of aldose reductase inhibitors to prevent diabetic complications, an epidemiological study of the effect of tea consumption on the pathogenesis and progression of diabetic complications would be interesting.
FROGS: A serial reversible greedy search algorithm (2012)

For compressed sensing, in the framework of greedy search reconstruction algorithms, we introduce the notion of initial support-set. The initial support-set is an estimate given to a reconstruction algorithm to improve the performance of the reconstruction. Furthermore, we classify existing greedy search algorithms as being serial or parallel. Based on this classification and the goal of robustness to errors in the initial support-sets we develop a new greedy search algorithm called FROGS. We end the paper with careful numerical experiments concluding that FROGS perform well compared to existing algorithms (both in terms of performance and execution time) and that it is robust against errors in the initial support-set.
De com els altars també es mouen: L’ALTAR DE SANTA MARIA DEL COR DE (2000)

DE COM ELS ALTARS TAMBE ES MOUEN:
L’ALTAR DE SANTA MARIA DEL COR DE
L’ESGLESIA DE SANT CRISTOFOL DE
TAVERTET.
Enamel Protein Amelotin-Coated Nano Hydroxyapatite for Accelerated Dentin Remineralization (2020)

Remineralization of demineralized dentin is of considerable clinical interest as it may prevent failure in dental restoration. Amelotin (AMTN) is an enamel protein that has a direct influence on the biomineralization of enamel by promoting hydroxyapatite mineralization. In this study, we harnessed the mineral-inducing properties of AMTN to remineralize demineralized dentin by coating the protein on hydroxyapatite nanoparticles (HANP). Collagen gel and demineralized dentin sections of human third molars were used as our model system. It was shown that AMTN coated HANP accelerates the formation of a larger and more homogeneous mineral surface with higher crystallinity on both collagen and demineralized dentin.
Improved Dynamic Cardiac Phantom Based on 4D NURBS and Tagged MRI (2020)

We previously developed a realistic phantom for the cardiac motion for use in medical imaging research. The phantom was based upon a gated magnetic resonance imaging (MRI) cardiac study and using 4D non-uniform rational b-splines (NURBS). Using the gated MRI study as the basis for the cardiac model had its limitations. From the MRI images, the change in the size and geometry of the heart structures could be obtained, but without markers to track the movement of points on or within the myocardium, no explicit time correspondence could be established for the structures. Also, only the inner and outer surfaces of the myocardium could be modeled. We enhance this phantom of the beating heart using 4D tagged MRI data. We utilize NURBS surfaces to analyze the full 3D motion of the heart from the tagged data. From this analysis, time-dependent 3D NURBS surfaces were created for the right (RV) and left ventricles (LV). Models for the atria were developed separately since the tagged data only covered the ventricles. A 4D NURBS surface was fit to the 3D surfaces of the heart creating time-continuous 4D NURBS models. Multiple 4D surfaces were created for the left ventricle (LV) spanning its entire volume. The multiple surfaces for the LV were spline-interpolated about an additional dimension, thickness, creating a 4D NURBS solid model for the LV with the ability to represent the motion of any point within the volume of the LV myocardium at any time during the cardiac cycle. Our analysis of the tagged data was found to produce accurate models for the RV and LV at each time frame. In a comparison with segmented structures from the tagged dataset, LV and RV surface predictions were found to vary by a maximum of 1.5 mm’s and 3.4 mm’s respectively. The errors can be attributed to the tag spacing in the data (7.97 mm’s). The new cardiac model was incorporated into the 4D NURBS-based Cardiac-Torso (NCAT) phantom widely used in imaging research. With its enhanced abilities, the model will provide a useful tool in the study of cardiac imaging and the effects of cardiac motion in medical images.
Valeur diagnostique des petits ARN dérivés des ARNY (ou RNY) dans les cardiopathies coronariennes (2016)

peer reviewed
Human exposure monitoring and evaluation in the Arctic: the importance of understanding exposures to the development of public health policy. (2003)

Arctic indigenous peoples face significant challenges resulting from the contamination of Arctic air, water, and soil by persistent organic pollutants, heavy metals, and radionuclides. International cooperative efforts among governments and research institutions are under way to collect the information needed by environmental health scientists and public health officials to address environmental contamination in the Arctic. However, the climatic, political, and cultural conditions of the land and its native populations combine to present a unique set of scientific and logistic challenges to addressing this important public health issue. Public health officials have the responsibility to respect the cultural traditions of indigenous communities, while simultaneously designing strategies that will reduce their exposure to environmental contaminants and rates of disease and dysfunction. Researchers can better understand the link between environmental exposures and disease through monitoring programs for both the subsistence diets and health status of the indigenous populations. We suggest that the incorporation of community-based participatory research methods into programs designed to assess biomarkers of contaminant exposure in children and adults may be a valuable addition to ongoing and newly developed research programs. This approach could serve as a model for international environmental health initiatives, because it involves the participation of the local communities and seeks to builds trust between all stakeholders.
Structure and Wear of TiN Films Formed by Dynamic Mixing Process. (1991)

TiN films have been formed by dynamic mixing (DM) process, in which N ions are implanted during Ti evaporation or TiN reactive evaporation under low or high N2 gas pressure. Structure and wear characteristics of the films have been investigated by comparison with TiN films formed by the conventional reactive evaporation process.Rutherford backscattering spectroscopy and electron probe microanalysis showed that the composition ratio (N/Ti) of the TiN films formed by DM process is above 1.5, and that oxygen concentration is lower than in films formed by conventional reactive evaporation. In DM process, the N/Ti ratio of films formed under high N2 gas pressures was slightly larger than that of films formed under low pressures. Transmission electron microscopy showed that the grain of the films produced by DM process were coarser than those of the films formed by reactive evaporation.In a dry reciprocating rubbing test vs SUJ 2 steel, films produced by reactive evaporation were easily worn out and it is thought that the wear resistance of films made by DM process is superior to that of films made by reactive evaporation. With DM process, no matter how N2 gas pressure varies, there are no large differences in the wear characteristics of the films.
Positioning Systems in Intelligent Transportation Systems (1997)

From the Publisher:
Positioning systems, which determine the location of cars, trucks, buses, trains, and airplanes, are critical in the use of intelligent transport systems (ITS) to improve the efficiency and safety of transport systems while making them less congested and less polluting. This book is the first integrated study of the role of positioning systems in ITS, the major types of positioning systems, the relationship between them, and methods for evaluating their performance. 

The content is also unique in that it covers the construction and use of maps for positioning, addresses the Global Positioning System (GPS), and discusses emerging positioning technologies such as Quiktrak and cellular mobile telephones. In addition, the book examines both the role of positioning in the architecture of ITS  and the suitability of various positioning systems for specific applications. Case studies further illustrate a method for analyzing ITS positioning requirements.

This authoritative reference can help you save time and money by selecting and developing the most appropriate solutions. Specifically, it will help you: 

? Determine specifications of positioning systems for ITS
? Identify the different types of positioning systems
? Understand the high-level operation of positioning systems
? Match positioning systems to ITS applications
? Understand high-level mapping issues
? Conceptualize the operation of positioning system components

The book provides a wealth of information highly useful for transportation, electrical, and software engineers who are responsible for integrating positioning systems into broader ITS applications ordesigning new positioning systems for ITS. It is also an important source for positioning systems experts who need to gain a better understanding of ITS.
Discovery and Exploitation of AZADO: The Highly Active Catalyst for Alcohol Oxidation (2013)

The oxidation of primary and secondary alcohols to the corresponding aldehydes (or carboxylic acids) or ketones is a fundamental transformation in organic synthesis. Stable organic nitroxyl radicals as represented by 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) (1) have been used extensively to catalyze the oxidation of a number of alcohol substrates employing environmentally benign co-oxidants such as bleach (NaOCl) or PhI(OAc)2. Although TEMPO oxidation is better known as a method for selective oxidation of primary alcohols to the corresponding aldehydes, the TEMPO-based method is not very efficient for the oxidation of structurally hindered secondary alcohols. We designed and synthesized 2-azaadamantane N-oxyl [AZADO (11)] and 1-Me-AZADO (20), a structurally less hindered class of nitroxyl radical. AZADOs were found to exhibit excellent catalytic activity enabling oxidation of a variety of alcohols with which TEMPO exhibits poor reactivity. Based on structure-activity relationships (SAR) employing AZADO (11), 1-Me-AZADO (20), 1,3-dimethyl-AZADO (33), 9-azabicyclo[3.3.1]nonane-N-oxyl [ABNO (34)] and 9-azanoradamantane N-oxyl [Nor-AZADO (37)], we concluded that the α-methyl group flanked nearby the nitroxyl group affects the reactivity for the oxidation of sterically hindered alcohols and the azaadamantane skeleton contributes to the high turnover of the catalyst. The highly active nature of AZADOs spurred us to exploit their further use in alcohol oxidations. A facile, green, one-pot oxidation of primary alcohols to carboxylic acids with broad substrate applicability has been developed by employing an expedient catalytic system consisting of the oxoammonium salt [1-Me-AZADO(+)X(-) (X=Cl, BF4)]/NaClO2. The synthetic use of AZADOs and the related nitroxyl radicals/oxoammonium salts-based methods for alcohol oxidation have been demonstrated in several total syntheses of natural products. We also describe the development of a Nor-AZADO (37)/DIAD/AcOH method that offers exceptionally mild and highly chemoselective oxidation of alcohols.
A Multi-Agent Framework for Testing Distributed Systems (2006)

Software testing is a very expensive and time consuming process. It can account for up to 50% of the total cost of the software development. Distributed systems make software testing a daunting task. The research described in this paper investigates a novel multi-agent framework for testing 3-tier distributed systems. This paper describes the framework architecture as well as the communication mechanism among agents in the architecture. Web-based application is examined as a case study to validate the proposed framework. The framework is considered as a step forward to automate testing for distributed systems in order to enhance their reliability within an acceptable range of cost and time.
On-site identification of ozone damage in fruiting plants using vapor-deposited conducting polymer tattoos (2020)

Climate change is leading to increased concentrations of ground-level ozone in farms and orchards. Persistent ozone exposure causes irreversible oxidative damage to plants and reduces crop yield, threatening food supply chains. Here, we show that vapor-deposited conducting polymer tattoos on plant leaves can be used to perform on-site impedance analysis, which accurately reveals ozone damage, even at low exposure levels. Oxidative damage produces a unique change in the high-frequency (>10<sup>4</sup> Hz) impedance and phase signals of leaves, which is not replicated by other abiotic stressors, such as drought. The polymer tattoos are resilient against ozone-induced chemical degradation and persist on the leaves of fruiting plants, thus allowing for frequent and long-term monitoring of cellular ozone damage in economically important crops, such as grapes and apples.
Novel modifications of peptides: simple syntheses of difunctionalized enamines, enol ethers, and thioenol ethers from carboxylic acids via acylimidazole and enol phosphate intermediates (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel modifications of peptides: simple syntheses of difunctionalized enamines, enol ethers, and thioenol ethers from carboxylic acids via acylimidazole and enol phosphate intermediatesGilles Sauve, Nicolas Le Berre, and Boulos ZacharieCite this: J. Org. Chem. 1990, 55, 10, 3002–3004Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/jo00297a008https://doi.org/10.1021/jo00297a008research-articleACS PublicationsRequest reuse permissionsArticle Views255Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
DNA vaccines for cervical cancer: from bench to bedside (2007)

More than 99% of cervical cancers have been associated with human papillomaviruses (HPVs), particularly HPV type 16. The clear association between HPV infection and cervical cancer indicates that HPV serves as an ideal target for development of preventive and therapeutic vaccines. Although the recently licensed preventive HPV vaccine, Gardasil, has been shown to be safe and capable of generating significant protection against specific HPV types, it does not have therapeutic effect against established HPV infections and HPV-associated lesions. Two HPV oncogenic proteins, E6 and E7, are consistently co-expressed in HPV-expressing cervical cancers and are important in the induction and maintenance of cellular transformation. Therefore, immunotherapy targeting E6 and/or E7 proteins may provide an opportunity to prevent and treat HPV-associated cervical malignancies. It has been established that T cell-mediated immunity is one of the most crucial components to defend against HPV infections and HPV-associated lesions. Therefore, effective therapeutic HPV vaccines should generate strong E6/E7-specific T cell-mediated immune responses. DNA vaccines have emerged as an attractive approach for antigen-specific T cell-mediated immunotherapy to combat cancers. Intradermal administration of DNA vaccines via a gene gun represents an efficient way to deliver DNA vaccines into professional antigen-presenting cells in vivo. Professional antigen-presenting cells, such as dendritic cells, are the most effective cells for priming antigen-specific T cells. Using the gene gun delivery system, we tested several DNA vaccines that employ intracellular targeting strategies for enhancing MHC class I and class II presentation of encoded model antigen HPV-16 E7. Furthermore, we have developed a strategy to prolong the life of DCs to enhance DNA vaccine potency. More recently, we have developed a strategy to generate antigen-specific CD4(+) T cell immune responses to further enhance DNA vaccine potency. The impressive pre- clinical data generated from our studies have led to several HPV DNA vaccine clinical trials.
Structuring interfaces (1996)

Software components are often described by interfaces organised as sets of externally visible elements, such as signatures of callable functions and procedures, or types of messages and signals accepted by the component. While it is a common practice to construct larger components by composing smaller ones and abstracting their function, interfaces of composite, higher-level components are still described as sets of function signatures or message types. This situation indicates a granularity mismatch between the level of abstraction of components and their interfaces. We believe that just as components are structured as compositions of lower level components, interfaces must be structured as compositions of lower level interfaces. In this paper we present an approach to structuring and describing interfaces of large software components. We model interfaces as collections of interface objects that have state and may exhibit non-trivial behaviour. We also compose basic interface elements such as functions signatures and event types into composite elements that we call interactions. Interactions correspond to meaningful, from the component user point of view, services provided by interface objects.
The Offshore Bucket Trail Installation (2015)

The Bucket Trail Installation project has gathered a substantial amount of date in a unique soil database which enable update of the used standards for penetration prediction. This update will lead to less conservative design of bucket foundations and is vital for the aim of cost reduction in the offshore wind business. Furthermore is serial offshore operation with the bucket concept was demonstrated with achieving full installation depth and inclination within given tolerance.