gebhart/patrepeval huggingface dataset:
Effect of Limestone and Quartz Fillers in UHPC with Calcined Clay (2022)

Ultra-high-performance concrete (UHPC) is a material developed to maximize the engineering characteristics of hydraulic concrete, in terms of durability and mechanical properties, but the adoption of this technology in practice has not turned out as desired, mainly due to the high amounts of cement and silica fume required for its production, and for its consequences on both economic and ecological costs. As an option to improve the impact of UHPC, both on costs and on sustainability, this work evaluates four UHPC series with metakaolin additions of 5%, 10%, 15% and 20%, and the substitution of 37.5% of the Portland cement volume by limestone or quartz filler. The compressive strength, the bulk electrical resistivity and a set of tests for microstructural characterization (TGA, XRD and quantitative EDS) were utilized to better understand the role of calcite on the hydration and pozzolanic reactions in ternary Portland cement-metakaolin-limestone filler. Results indicate that the reaction of calcite is scarce and should be considered as a mere filler, as no increase in AFm phases were found. Nevertheless, the ternary mixture with 15% of metakaolin in addition to cement, and with 37.5% of the Portland cement volume substituted by limestone filler, was the one that presented the best performance in terms of compressive strength and bulk electrical resistivity. The results of the microstructural characterization indicate that the high kaolin content in the metakaolin originated the most significant hydration and pozzolanic reactions development between the ages of 7 and 28 days, as between 28 and 91 the reaction remained dormant. In general, the whole set of results included in this work indicate that limestone filler doesn't act as a better filler than other kind of powders when used in ternary Portland cement-metakaolin- filler systems.
In Vitro Modeling of Complex Neurological Diseases (2017)

A major reason for the lack of effective therapeutics and a deep biological understanding of complex diseases, which are thought to result from a complex interaction between genetic and environmental risk factors, is the paucity of relevant experimental models. This review describes a novel experimental approach that allows the study of the functional effects of disease-associated risk in complex disease by combining genome wide association studies (GWAS) and genome–scale epigenetic data to prioritize disease-associated risk variants with efficient gene editing technologies in human pluripotent stem cells (hPSCs). As a proof of principle, we recently used such a genetically precisely controlled experimental system to identify a common Parkinson’s disease-associated risk variant in a non-coding distal enhancer element that alters the binding of transcription factors and regulates the expression of α-synuclein (SNCA), a key gene implicated in the pathogenesis of Parkinson’s disease.
Avian Influenza Prevalence and Viral Shedding Routes in Minnesota Ring-Billed Gulls (Larus delawarensis) (2018)

Birds within the orders Charadriiformes (shorebirds, gulls) and Anseriformes (waterfowl) are reservoir hosts for avian influenza (AI) viruses, but their role in the transmission dynamics of AI viruses is unclear. To date, waterfowl have been the predominant focal species for most surveillance and epidemiological studies, yet gulls, in particular, have been shown to harbor reassortant AI viruses of both North American and Eurasian lineages and are underrepresented in North American surveillance efforts. To address this gap in surveillance, 1346 ring-billed gulls (<i>Larus delawarensis</i>) were sampled during spring and fall migrations and at three breeding sites in 2017 across Minnesota. Results indicate noticeable age-cohort dynamics in AI virus prevalence within ring-billed gulls in Minnesota. Immunologically naïve juveniles represented the cohort with the highest prevalence rate (57.8%). Regardless of age, more gulls had AI virus detected in oropharyngeal (OP) than in cloacal (CL) swabs. The high AI virus prevalence within ring-billed gulls, particularly in immunologically naïve birds, warrants further targeted surveillance efforts of ring-billed gulls and other closely related species.
The Psychophysiological Investigations of Myocardial Ischemia (PIMI) Study (1998)

Study design, quality control data, and baseline characteristics of patients enrolled for a clinical study of symptomatic and asymptomatic myocardial ischemia are described. Lower repeatability of reading wall motion abnormalities during mental stress than during exercise may be due to smaller effects on wall motion and lack of an indicator for peak mental stress.
Collaborative Information Space Analysis Tools (1998)

The DASHER Project at USC/ISI has focused upon helping organizations with rapid-response mission requirements. Such organizations need to be able to quickly stand up tiger teams backed by the information, materiel, and support services they need to do their job. To do so, they need to find and assess sources of those services who are potential participants in the tiger team. To support this very initial phase of team development, the project has developed information analysis tools that help make sense of sets of data sources in an intranet or internet: characterizing them, partitioning them, sorting and filtering them. These tools focus on three key issues in forming a collaborative team: helping individuals responsible for forming the team to understand what is available, helping them structure and categorize on the information available to them in a manner specifically suited to the task at hand, and helping them understand the mappings between their organization of the information and those used by others who might participate. DASHER’s Information Space Analysis Tools are unique in combining multiple methods to assist in this task. This makes the suite particularly well-suited to integrating additional technologies in order to create specialized systems.
The Interaction Between Thick Film Conductors and Low Ohmic Resistors (1986)

For thick film resistor materials with low sheet resistivity (less than 10 ohm/□) sheet resistivity increases with decreasing resistor length, when terminated with Pd alloy based conductors. This is due to the reaction of palladium from the thick film conductor and bismuth ruthenate (Bi2Ru2O7), which is the active phase in thick film resistor material. The experimental results indicate the formation of Pd/Bi solid solution on the interface between the conductor and resistor. Because of its higher specific resistivity, this layer functions as an additional source of resistivity.
Purified MHC Class I and Peptide Complexes Activate Naive CD8+ T Cells Independently of the CD28/B7 and LFA-1/ICAM-1 Costimulatory Interactions (1998)

T cells play a central role in the initiation, maintenance, and regulation of the immune response. Effector responses of T cells are controlled by complex combinations of lymphokines and adhesion/costimulatory molecule signals. To isolate the effects of specific adhesion/costimulatory molecules and to define the minimal molecular requirements of naive CD8+ T cell activation, we have developed an APC-free system for stimulation of naive CD8+ T cells. In this report, we demonstrate that immobilized MHC class I-peptide complexes can activate naive CD8+ T cells from TCR transgenic mice at low cell densities. The CD8+ T cells were stimulated to proliferate and secrete IL-2 independently of the molecular interactions between CD28/B7.1-B7.2 or LFA-1/ICAM-1 surface receptors. Previous reports have shown that CD28 ligation is necessary for late T cell survival of APC-stimulated naive CD8+ T cells. Our data suggest that under certain specific conditions of high intensity T cell signaling, early activation and late cell proliferation can occur independently of APC-derived costimulatory signals.
DAC nonlinearity effects in a wide-band sigma-delta modulator architecture (2003)

This paper presents an alternative approach for the robust implementation of wideband sigma-delta modulators. The proposed topology consists of a pipelined cascaded sigma-delta modulator. To make quantization noise sources negligible at OSR of 8 both stages utilize multibit quantizers. To reduce sensitivity to opamp nonlinearities, both stages are implemented using the sigma-delta modulator with feedforward path. The nonlinearity effects on the modulator performance are analyzed. The simulation results show that the multibit DAC nonlinearity dominates the harmonic distortion and intermodulation distortion. The proposed sigma-delta modulator achieves an 85 dB SNR and 95 dB SFDR in the 6 MHz bandwidth, for 96 MHz sampling frequency.
A RANDOMIZED, BLINDED, CROSSOVER TRIAL OF AN IN-HOME DRINKING WATER INTERVENTION TO REDUCE GASTROINTESTINAL ILLNESS (2003)

Methods Design A randomized, triple-blinded crossover intervention trial from Nov 2000 to May 2002. Setting Private residences in a community using conventional water treatment on the Mississippi River in Davenport, Iowa, USA. Patients. 1296 healthy volunteers (from 456 households) who primarily consumed municipal tap water prior to the study. Intervention Households were randomized to externally identical active or sham water treatment devices for the first six months (Cycle A). Each household was then switched to the opposite device, blinded to device type, for the second six months (Cycle B). The active device had an absolute 1-micron filter and an ultraviolet light. The sham device was externally identical. An electronic totalizer within each device measured its usage. Blinding of subjects to device assignment was monitored. Main Outcome Measures Blinding was measured using a previously published blinding index (BI), similar to the kappa statistic (in perfect blinding, BI = 1.0). Illness was measured using ‘highly credible gastrointestinal illness’ IHCGI), a published measure that includes symptoms of diarrhea, nausea, vomiting, and abdominal cramps. Results 1,116 person-years of observation time were recorded during the trial. Participants completed 86% of scheduled health diaries. BI was 0.85, 95% CI 0.82–0.87 at study end. There was no difference in daily water consumption (p = 0.24) among active vs. sham device households and total daily water use was 2.46 l/household. The rate of HCGI in the entire cohort was 2.26 episodes/person/year (95% CI 2.17–2.35). Conclusion This is the first drinking water intervention trial conducted using a randomized, blinded, cross-over design. Exposure (i.e. device use) was comparable during periods of active and sham device assignment. The study was successful with respect to blinding and subject participation. Rates of illness stratified by device type will be presented at the conference.
Effect of stem cell factor on in vitro erythropoiesis in patients with bone marrow failure syndromes (1992)

Stem cell factor (SCF) enhances normal hematopoiesis. We examined its effect in vitro on bone marrow and blood progenitors from patients with inherited bone marrow failure syndromes, including 17 patients each with Diamond-Blackfan anemia (DBA) and Fanconi's anemia (FA), 3 with dyskeratosis congenita (DC), and 1 each with amegakaryocytic thrombocytopenia (amega) and transient erythroblastopenia of childhood (TEC). Mononuclear cells were cultured with erythropoietin (Ep) alone or combined with SCF or other factors. SCF increased the growth of erythroid progenitors in cultures from 50% of normal controls, 90% of DBA, 70% of FA, 30% of DC, and the amega and TEC patients; normal numbers were reached in 25% of DBA studies. Improved in vitro erythropoiesis with SCF in all types of inherited marrow failure syndromes does not suggest a common defect involving kit or SCF, but implies that SCF may be helpful in the treatment of hematopoietic defects of varied etiologies.
An Analysis to LME Rules and its Inspiration to Domestic Futures Market Development (2009)

London Metal Exchange(short as LME) is the most authoritative,influential metal exchange,with biggest commodity types,most sophisticated transaction policy and facility,which is basically a futures exchange.As the world economy develops,especially the developing of metal industry,LME has been continuously modify its rules to accommodate industry need,which is a comprehensive rule system that keeps up with the time and benefit traders all over the world in light of hedging,delivery,investment,etc.Studying the LME rules and its successful experience will provide a good reference for domestic futures market to supply better quality market service and for the innovation and development of domestic market.LME's success comes with its unique rules system and operation mode,which is shown in its membership structure,transaction,contract arrangement,risk control system,delivery setup,delivery strategy,as well as the dispute solving system.Favoring Spot Transaction is most unique and successful experience of LME's many rules,which is also how LME illustrates perfectly Futures market is a supplement to spot market.
Word-interleaved cache (2008)

We propose a novel energy-efficient data cache architecture, namely, word-interleaved (WI) cache. In theWI cache, a cache block is distributed uniformly among the different cache ways and each line of a cache way holds some words of the block. This distribution provides an opportunity to activate/deactivate the cache ways based on the requested address's offset, thus minimizing the overall cache access energy. For a 4-way set associative cache of size 16KB and blocksize 32B, the proposed technique accomplishes dynamic energy savings of 54.2% without considering fast hits and 62.3% when fast hits are considered, with small performance degradation and negligible area overhead.
ACTIVATED PROTEIN C RESISTANCE DUE TO A COMMON FACTOR V GENE MUTATION IS A MAJOR RISK FACTOR FOR VENOUS THROMBOSIS (1997)

Inherited resistance to activated protein C (APC) was recently discovered to be a cause of familial thrombophilia and is now known to be the most common genetic risk factor for venous thrombosis. It is caused by a single point mutation in the gene for factor V, which predicts substitution or arginine (R) at position 506 with a glutamine (Q). Accordingly, the activated form of mutated factor V (FVa:Q506) is more slowly degraded by activated protein C than normal FVa (FVa:R506) is, resulting in hypercoagulability and a lifelong 5- to 10-fold increased risk of venous thrombosis. Previously known inherited hypercoagulable states, i.e. deficiencies of the anticoagulant proteins antithrombin III, protein S, and protein C, are found fewer than 10-15% of thrombosis patients in western countries, whereas inherited APC resistance is present in 20-60% of such patients. The FV mutation is common in populations of Caucasian origin, with prevalences ranging from 1-15%, whereas it is not found in certain other ethnic groups such as Japanese and Chinese. The high prevalence of APC resistance, in combination with the availability of simple laboratory tests, will have a profound influence on the development of therapeutic and prophylactic regimens for thrombosis and will, it is hoped, result in a decreased incidence of thromboembolic events.
ParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures (2014)

ParaPep is a repository of antiparasitic peptides, which provides comprehensive information related to experimentally validated antiparasitic peptide sequences and their structures. The data were collected and compiled from published research papers, patents and from various databases. The current release of ParaPep holds 863 entries among which 519 are unique peptides. In addition to peptides having natural amino acids, ParaPep also consists of peptides having d-amino acids and chemically modified residues. In ParaPep, most of the peptides have been evaluated for growth inhibition of various species of Plasmodium, Leishmania and Trypanosoma. We have provided comprehensive information about these peptides that include peptide sequence, chemical modifications, stereochemistry, antiparasitic activity, origin, nature of peptide, assay types, type of parasite, mode of action and hemolytic activity. Structures of peptides consisting of natural, as well as modified amino acids have been determined using state-of-the-art software, PEPstr. To facilitate users, various user-friendly web tools, for data fetching, analysis and browsing, have been integrated. We hope that ParaPep will be advantageous in designing therapeutic peptides against parasitic diseases. Database URL: http://crdd.osdd.net/raghava/parapep/
Magnesium hydridotriphenylborate [Mg(thf)6][HBPh3]2: a versatile hydroboration catalyst (2016)

Magnesium bis(hydridotriphenylborate), isolated as a solvent-separated ion pair [Mg(thf)<sub>6</sub>][HBPh<sub>3</sub>]<sub>2</sub>, effectively catalyzed the hydroboration of several unsaturated substrates including CO<sub>2</sub>.
Do You Need to Be Intelligent to Play Games? (2019)

Shall we play a game? You choose: Chess, Super Mario Bros., or Angry Birds. I'm giving you a choice because I don't know whether you are familiar with all three of them. I talked about Chess in the previous chapter: the Western's world's arguably most famous board game, played by physically moving pieces such as pawns, kings, and queens on a board with alternating black and white squares. By moving these pieces so that they threaten and capture your opponent's pieces, you can ultimately win over your opponent by surrounding her king. It has changed little since it was invented millennia ago.
روندهای مذهبی در ایران اسلامی آغازین (1990)

استاد مادلونگ از برجسته‏ترین اسلام شناسان غربی است که پس از سالها تدریس‏ در دانشگاه شکاگو از حدود یک دهه قبل به عنوان Laudian Professor of Arabic در دانشگاه آسکفونرد به تدریس زبان عربی و تاریخ و تفکر اسلامی اشتغال داشته است. مادلونگ بخصوص در زمینهء فرقه‏های شیعه و دیگر نهضت‏های مذهبی و کلامی صدر اسلام تحقیقات بسیار ارزشمندی انجام داده و صاحب تألیفات زیادی است که برخی از آنها در دانشنامهء اسلام و دانشنامهء ایرانیکا انتشار یافته است.استاد مادلونگ چکیده‏هایی‏ از تحقیقات و عقاید خود را در زمینه‏های تخصصی‏اش در پنج خطابه در دسامبر 1983 در دانشگاه کلمبیا ارائه داد و اکنون آن خطابه‏ها با اضافاتی(دربارهء خوارج و متصوفه)در کتابی کوچک و پرمایه در مجموعهء Bibliotheca Persica ،به سرپرستی دکتر احسان یارشاطر،انتشار یافته است.
"Une histoire de microbes : entre immunité et Stress !" Grand Public - Visioconférence (2021)

CERVOXY
Oriented growth and electrical property of LiAl<sub>5</sub>O<sub>8</sub> film by laser chemical vapor deposition (2015)

LiAl5O8 films were prepared by laser chemical vapor deposition, and the effect of the deposition temperature (Tdep) on the orientation, microstructure, and deposition rate was investigated. In the Tdep range of 980–1040 K, highly (110)-oriented LiAl5O8 film comprising flake-like grains elongated to [110] with flatter face of (111) formed at the maximum deposition rate of 70 µm h−1. Above Tdep = 1050 K, dense LiAl5O8 films slightly oriented to (100) were deposited with faceted columnar grains of pyramidal and terrace shapes. The electrical properties of the LiAl5O8 films were examined using AC impedance spectroscopy. The complex plane plots of the dense LiAl5O8 film consisted of a semicircle associated with the bulk response and an inclined spike, suggesting the ionic conduction in the LiAl5O8 film.
Hydrogen-nitrous oxide flame study (1982)

Laser fluorescence and absorption spectroscopy have been used to investigate a stoichiometric H/sub 2//N/sub 2/O flame stabilized on a porous plug flat flame burner at atmospheric pressure. Concentration profiles of OH, NH and NO, and the temperature profile were obtained. A detailed chemical kinetic mechanism which describes the flame chemistry was evaluated using a one-dimensional flame code which included multicomponent diffusional transport. This chemical kinetic mechanism was able to predict the observed OH, NH, and NO concentration levels within the experimental accuracy. These concentration levels were found to depend strongly on the two product channels of the H + N/sub 2/O reaction: N/sub 2/ + OH and NH + NO.
In Vivo Beurteilung der Luciferaseaktivität nach Anwendung von Fokussiertem Ultraschall (2011)

Ziele: Evaluierung der Luciferaseaktivität im Muskelgewebe nach der Anwendung von Fokussiertem Ultraschall. Methode: Muskelgewebe von 25 Balb/c Mäusen wurde mit einem Plasmid, unter Verwendung des CMV Promotors und der Luciferase als Reportergen, transfiziert. 10 Tage nach der Transfektion wurde mit einem dualen bildgebenden (6MHz)/therapeutischen (1MHz) Ultraschallsystems (Focus Surgery, Indianapolis) das Muskelgewebe im kontinuierlichen Modus für 20 Sekunden beschallt. Fünf unterschiedliche Energiestufen (4133 W/cm2, 3067 W/cm2, 2157W/cm2, 1401W/cm2, 802W/cm2) wurden angewandt. Anschließend erfolgte eine MRT-Bildgebung (1.5 T GE Signa) unter Verwendung einer diffusionsgewichteten STEAM-Sequenz (TR=6000ms, TE=30ms, NEX=8, δ=9ms, Δ=170ms, b-values=50, 250, 500, 750, 1000 (s/mm2)). Die Bestimmung der Genexpression erfolgte über einen Zeitraum von 2 Wochen mit einem optischen Bildgebungssystem (IVIS, Xenogen, Alameda, USA). Ergebnis: Die Diffusionskoeffizienten und die T2 Zeiten variierten abhängig von der angewandten Energie. Bei einer Intensität von 4133 W/cm2 betrug der Diffusionskoeffizient des behandelten Gewebes D=(1.30+/-0.03) 10–3 mm2/s bei einer T2-Zeit von 117.49+/-6.74ms hierbei zeigte sich eine Reduktion der Luciferaseaktivität um 83%. Bei einer Intensität von 2157 W/cm2 betrug der Diffusionskoeffizient im Muskelgewebe D=(0.98+/-0.03)10–3 mm2/s und die T2 Zeit 63.91+/-3.90ms hierbei zeigt sich eine um 410% höhere Luciferaseaktivität.Bei einer Intensität von 802W/cm2 betrug der mittlere Diffusionkoeffizient D=(0.84+/-0.04)10–3 mm2/s und die T2=46.34 +/-1.18ms. Bei diesen Parametern zeigte sich ebenso eine erhöhte Luciferaseaktivität um 250% verglichen mit der Reportergenaktivität vor der Anwendung von Fokussiertem Ultraschall (D=(0.68+/-0.04)10–3 mm2/s; T2=(36.3403+/-1.1827)ms). Schlussfolgerung: Fokussierter Ultraschall führt zu einer Induktion der Luciferaseaktivität unter der Kontrolle eines CMV-Promotors
The Monosodium Glutamate Story: The Commercial Production of MSG and Other Amino Acids (2004)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Monosodium Glutamate Story: The Commercial Production of MSG and Other Amino AcidsAddison Ault View Author Information Department of Chemistry, Cornell College, Mount Vernon, IA 52314Cite this: J. Chem. Educ. 2004, 81, 3, 347Publication Date (Web):March 1, 2004Publication History Received3 August 2009Published online1 March 2004Published inissue 1 March 2004https://pubs.acs.org/doi/10.1021/ed081p347https://doi.org/10.1021/ed081p347research-articleACS PublicationsRequest reuse permissionsArticle Views3256Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Additives,Fermentation,Molecular structure,Monomers,Peptides and proteins Get e-Alerts