gebhart/patrepeval huggingface dataset:
Multistep Incremental Forming beyond 100° (2021)

While Incremental Sheet Forming (ISF) is approaching accuracy levels suitable for industrial take-up for specific applications, limited forming angles are still a great concern, leaving many applications out of reach. In this paper a two sided strategy for multistep incremental forming is presented, aiming at increased uniform wall thickness. By sequentially forming steeper wall angles, alternating passes between front and back side of the sheet, wall angles up to 105.5° were successfully reached in AA3103 with a blank thickness of 1.5mm. A resulting minimal thickness of 0.4mm and thickness range of 0.2mm was achieved for the 105.5°part.
Intranasal administration of fusidic acid cream in leprosy. (2001)

The effect of local treatment of nostrils with fusidic acid cream was investigated in 30 previously untreated lepromatous leprosy patients. The cream was applied in the nostrils after flushing the nostrils with normal saline, twice a day for a period of four weeks. It was found that 20 mg/gm of sodium fusidate was effective in reducing the morphological index of the nose-blow smear to zero in two weeks in majority of the patients. No untoward side effect was seen in any of the patients. Such nasal treatment along with multidrug therapy may help in reducing the patient's level of infectiousness to their contacts, since the nose is recognized to be an important portal of exit of M. leprae.
Optimization of work roll taper for extremely-thin strip rolling. (1989)

A simulation model was developed for analyzing the ''roll-kiss'' phenomenon, i.e., a situation where the upper and lower work rolls contact each other in the roll barrel. As a result of the analysis, a theoretical method of providing taper on the work rolls was found. The applicability of the method was experimentally confirmed in a laboratory mill, and the following findings were obtained.(1) The accuracy of the load of roll-kiss calculation by Hertz's equation proved satisfactory for the practical use.(2) Analysis using the simulation model revealed two different configurations of roll-kiss.(3) The experimental results showed that for both configurations of roll-kiss, it is possible to prevent roll-kiss, by giving work rolls the optimum taper predicted from the simulation model.
Synthesis of Biomimetic Analogs of Neomycin B: Potential Inhibitors of the HIV RNA Rev Response Element (2000)

The aminoglycosidic antibiotic, neomycin B, is an inhibitor of the binding of Rev to RRE. This paper reports on the synthesis of analogs of neomycin B as potential anti-HIV compounds designed to function as inhibitors of Rev/RRE binding.
Influence of erythrocyte aggregation on leukocyte margination in postcapillary venules of rat mesentery (2000)

The role of erythrocyte (red blood cell; RBC) aggregation in affecting leukocyte (white blood cell; WBC) margination in postcapillary venules of the mesentery (rat) was explored by direct intravital microscopy. Optical techniques were refined and applied to relate the light-scattering properties of RBCs to obtain a quantitative index of aggregate size (G), which, under idealized conditions, represents the number of RBCs per aggregate. WBC margination, defined as the radial migration of WBCs to the venular wall and their subsequent rolling along the endothelium, was measured as the percentage of the potentially maximal WBC volumetric flux within the microvessel lumen (F(WBC)(*)). In normal blood, F(WBC)(*) increased exponentially fourfold, and G increased from 1 to 1.15 as wall shear rates () were reduced from a steady-state value of approximately 600 to <100 s(-1) by proximal occlusion with a blunt microprobe. Enhancement of aggregation by infusion (iv) of dextran 500 (428 kDa), to attain a systemic concentration of 3 g/100 ml, resulted in a four- and sevenfold increase in G and F(WBC)(*), respectively, as was reduced below 100 s(-1). Inhibition of RBC aggregation by infusion of dextran 40 (37.5 kDa) caused F(WBC)(*) to fall to one-half of its steady-state level for < 100 s(-1). Thus it appears that the well-known increase of WBC margination with reductions in is strongly dependent on the occurrence of RBC aggregation. Increasing the extent of RBC aggregation during reductions in also increased the firm adhesion of WBCs to the endothelium because of an enhanced probability of contact between leukocytes and the postcapillary venular wall.
Two New Inertial Algorithms for Solving Variational Inequalities in Reflexive Banach Spaces (2021)

The purpose of this paper is to introduce and analyze two inertial algorithms with self-adaptive stepsizes for solving variational inequalities in reflexive Banach spaces. Our algorithms are based on inertial hybrid and shrinking projection methods. Knowledge of the Lipschitz constant of the cost operator is not required. Under appropriate conditions, the strong convergence of the algorithms is established. We also present several numerical experiments which bring out the efficiency and the advantages of the proposed algorithms. Our work provides extensions of many known results from Hilbert spaces to reflexive Banach spaces.
IC‐P‐103: Prevalence and growth of cerebral microhemorrhages in autosomal dominant Alzheimer's disease (2013)

Cerebral microhemorrhages (MH), defined as small, hypointense lesions on T2/T2* weighted images, occur in approximately 23% of Alzheimer's disease (AD) cases. Furthermore, anti-amyloid treatment trials have been associated with the development of MHs . As a response to concerns about the safety of increased MH loads, the Alzheimer's Association Research Roundtable Workgroup recommended that individuals with more than 4 MHs be excluded from clinical trials. There is, however, only one extant in vivo study examining the prevalence of MH in autosomal dominant cases of AD (ADAD). With clinical trials of amyloid modifying agents soon to begin in ADAD populations, there is a pressing need to establish the prevalence of MH in this disease. Individuals from families with a history of ADAD were recruited at 11 sites worldwide, as part of the DIAN initiative. In total, 96 non-carriers (NC) and 142 carriers (M+) were studied. Longitudinal MH data was available for 25 non-carriers and 59 carriers. A 3T susceptibility-weighted imaging (SWI) sequence was used to quantify the number of MHs in each participant. Following the recommendation of Sperling et al., instances of siderosis were included along with MH counts. Approximately 26% (15/57) of symptomatic (CDR>0) ADAD mutation carriers had at least one MH (Table 1). Of the 142 mutation carriers, only 6 had more than four MHs. None of these participants carried the Dutch (Glu693Gln or E693Q) mutation subtype. Within mutation carriers there was clear association with CDR: both the M+/CDR=0.5 and M+/CDR>0.5 groups had greater MH counts than the M+/CDR=0 group (p<0.0001). Longitudinal imaging revealed that individuals with more than 4 MH at baseline showed a dramatic increase in the number of MHs at follow-up (Figure 1).
Learning Semantic Lexicons from a Part-of-Speech and Semantically (2003)

Special issue on inductive logic programming
High frequency eye tremor: reliability of measurement (1992)

Recent reports suggest that high frequency eye tremor or ocular microtremor (OMT) may be a useful indicator of brainstem function. The method of record analysis, and in particular the amount of record subjected to such analysis, has varied widely. We have recorded OMT from 10 normal subjects. Using these records we have performed 42 distinct replication reliability studies. We suggest seven parameters of OMT (including overall frequency of tremor) which may be of value in comparing abnormal with normal records. For each parameter we have determined the optimal duration of the record to analyse and the reliability of such analysis. Our results suggest that at least 5 s of OMT should be analysed to yield an acceptable estimate of all seven parameters.
Borel et la martingale de Saint-Pétersbourg (2018)

On se propose d'examiner sur un exemple, le paradoxe de Saint-Ptersbourg, la faon dont Borel expose la science de son temps.La premire partie indique sommairement la place singulire de la vulgarisation dans l'oeuvre de Borel.Les deux parties suivantes prsentent dans l'ordre chronologique les contributions borliennes au paradoxe de Saint-Ptersbourg qui s'chelonnent sur plus de cinquante ans ; elles indiquent comment Borel aborde le problme en le replaant dans une rflexion au long cours, scientifiquement trs riche, sur le paradoxe des martingales , ces systmes de jeu qui prtendent faire la fortune d'un joueur au jeu de pile ou face.Borel donne de ce problme une solution originale qui anticipe une galit fondamentale de la thorie mathmatique naissante des martingales.On signale en particulier le rle paradoxal jou par Flix Le Dantec dans le dveloppement de la pense borlienne sur ces thmes.Une annexe rtablit en langue moderne les martingales de Borel .
Non-Weighted L 2-Gain Analysis for Synchronization of Switched Nonlinear Time-Delay Systems With Random Injection Attacks (2023)

The current paper is devoted to studying global asymptotic <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$H_{\infty }$ </tex-math></inline-formula> drive-response synchronization for a kind of switched nonlinear time-delay systems with output random injection attacks (IAs). An attack-decomposition method is proposed to derive an attack-free signal, by which an observer is designed to estimate the state of the driving system. Then, two mode-dependent event-triggering mechanisms (MDETMs) are respectively designed for observer-controller (O-C) and controller-actuator (C-A) channels to save the communication resources as much as possible. In order to analyze the effects of the switching on the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$H_{\infty }$ </tex-math></inline-formula> performance, a mode-dependent discretized Lyapunov-Krasovskii functional (LKF) is developed, which has the merit of monotone decreasing on any time-interval and switching instants. Sufficient criteria are given to ensure the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$H_{\infty }$ </tex-math></inline-formula> synchronization with non-weighted <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mathcal {L}_{2}$ </tex-math></inline-formula> -gain, whether the attack is related to the output or not. Numerical simulations are provided to verify the non-weighted <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mathcal {L}_{2}$ </tex-math></inline-formula> -gain performance with low conservatism.
SELECTIVE WETTING OF POLYMERS BY SURFACTANT ADSORPTION DURING FROTH FLOTATION (1998)

ABSTRACT Different components of granulated plastic mixtures can be separated by froth flotation. This technique involves selective adherence of gas bubbles onto the particles to be separated. This requires a sufficient difference in the wettability of the particles. Since the overwhelming majority of plastics are hydrophobic by nature, separation by flotation necessitates selective wetting of the components. However, a comprehensive understanding of wetting phenomena involved has not been established thus far, so that the wetting action of surfactants during flotation cannot be predicted. As a consequence, selection of suitable wetting agents is essentially based on trial-error test work. However, the test work needed can largely be reduced by more insight into the wetting mechanisms involved which is the subject of the present work.
Humidity and Heat Effects on the Coefficient of Energy Dissipation (1974)

Six varieties of cotton are heat treated at temperatures of 100°C, 140°C, and 180°C. Frictional parameters, via coeffi cicnts of energy dissipation, are measured on each of these and control samples (20°C) at a number of consecutive relative humidities (30%, 45%, 55%, 65%, 80%, 65%, 55%, 45%, and 30%). The results for all combinations are discussed. Comparisons between these findings and those of other investigators are made.
Synthesis of near-infrared absorbing and fluorescing thiophene-fused BODIPY dyes with strong electron-donating groups and their application in dye-sensitised solar cells (2018)

Thiophene-fused BODIPY dyes with two diethylaminophenyl groups as strong donors demonstrated near-infrared (NIR) absorption (<italic>λ</italic><sub>max</sub>: 783–812 nm, <italic>ε</italic>: 119 500–145 900) and fluorescence (<italic>F</italic><sub>max</sub>: 862–916 nm, <italic>Φ</italic><sub>f</sub>: 0.02–0.12) in dichloromethane.
Diversity of Steroid Hormone Actions on the Brain (1999)

The nature of any long palindrome that might exist in the human genome is obscured by the instability of such sequences once cloned in Escherichia coli. We describe and validate a practical alternative to the analysis of naturally-occurring palindromes based upon cloning and propagation in Saccharomyces cerevisiae. With this approach we have investigated an intronic sequence in the human Neurofibromatosis 1 (NF1) locus that is represented by multiple conflicting versions in GenBank. We find that the site is highly polymorphic, exhibiting different degrees of palindromy in different individuals. A side-by-side comparison of the same plasmids in E.coli versus. S.cerevisiae demonstrated that the more palindromic alleles were inevitably corrupted upon cloning in E.coli, but could be propagated intact in yeast. The high quality sequence obtained from the yeast-based approach provides insight into the various mechanisms that destabilize a palindrome in E.coli, yeast and humans, into the diversification of a highly polymorphic site within the NF1 locus during primate evolution, and into the association between palindromy and chromosomal translocation.
Synthese und Einsatz von trägerfixierten Katalysatoren zur heterogen-katalysierten SiSi-Bindungsspaltung in Chlormethyldisilanen (1997)

Synthesis and Application of Immobilized Catalysts for the Heterogeneously Catalyzed Cleavage of the SiSi Bond of Chloromethyldisilanes Lewis bases like bis(dimethylamide)phosphoryl compounds (2, 5–7), N-heterocycles (8 and 9) and N,N-dialkylamino-3-propylsilanes bearing alkoxy groups are grafted via siloxane bonds onto silica carriers. The preparation and characterisation of 5–9 are reported. The grafted bis(dimethylamide)phosphoryl compounds (2, 5–7) and N-heterocycles (8, 9) are efficient catalysts for the disproportionation of chloromethyldisilanes into chloromethyloligosilanes and chloromethylsilanes. Grafted N,N-dialkylamino-3-propylsilyl compounds heterogeneously catalyze the SiSi bond cleavage of the disilanes with hydrogen chloride at 170 °C in excellent yields. A mixture of chloromethylmonosilanes is obtained. This reaction is also performed under pressure.
Investigations Concerning an Unexpected Reaction between the Dimsyl Anion ( = (Methylsulfinyl)methanide) and a γ,δ‐Epoxy‐ketone (1992)

Abstract The reaction of 2,2‐dimethyl‐5‐(1,2‐epoxypropyl)cyclohexanone ( 7 ) with t ‐BuOK in DMSO furnished a small amount of 5‐(1‐hydroxyprop‐2‐enyl)‐2,2‐dimethylcyclohexanone ( 12 ) and the 4 unexpected products 13–16 which contain one to three additional C‐atoms ( Scheme 2 ). The relative configuration of the major product 1‐(4′,4′‐dimethyl‐2′,3′‐dimethylidenecyclohexyl)propane‐1,2‐diol ( 15 ) was shown to be 1 RS , 2 RS ,1′ SR via NOE measurements performed on a derivative thereof. A crossover experiment in DMSO/[ 13 C 2 ]DMSO 1:1 as solvent showed that the two additional C‐atoms of this product originate from a single molecule of DMSO ( Scheme 5 ). A tentative mechanistic scheme, consistent with all experimental observations, is proposed which involves a [2,3]‐sigmatropic rearrangement of an (allylsulfinyl)methanide to a sulfenic acid as one of the key steps ( V → 24 , Scheme 8 ). We corroborated part of this hypothetic scheme by taking recourse to a model compound (7‐(methylsulfinyl)‐ p ‐mentha‐1,8‐diene ( 32/33 ), readily prepared in two steps from perilla alcohol ( 30 )), which reacted as predicted by the proposed mechanism ( Schemes 9 and 10 ).
Transcriptome Analyses Revealed Diverse Expression Changes in ago1 and hyl1 Arabidopsis Mutants (2009)

MicroRNAs (miRNAs) are 20-24 nucleotide endogenous regulatory molecules conserved in higher eukaryotes. In Arabidopsis, miRNAs are produced through step-wise cleavages of primary miRNA precursors (pri-miRNAs) by DICER-LIKE1 (DCL1). This cleavage step is also supported by a double-stranded RNA-binding protein, HYPONASTIC LEAVES1 (HYL1). In many cases, mature miRNA is predominantly incorporated into an endonuclease, ARGONAUTE1 (AGO1), which degrades miRNA-targeted mRNAs. Here, we examined and revealed whole genome transcriptomes in ago1-25 and hyl1-2 mutants using tiling arrays. The data in this paper are valuable for understanding the relationship between the miRNA pathway and its effect on transcriptomes.
Anion Effects on Ionization Efficiency Using Gold Nanoparticles as Matrices for LDI-MS (2009)

The effects of NaX and NH4X (X = F, Cl, Br, and I) on 337 nm laser desorption ionization (LDI) ion yields of peptides from size-selected citrate-capped gold nanoparticles (AuNPs) are investigated. The presence of NaF, NaCl, NaBr, and NH4X do not significantly affect analyte ion abundances, whereas addition of NaI strongly suppresses analyte ion yields. The LDI ion yields from AuNPs treated with β-mercaptoethanol, glutathione, or tiopronin are much less sensitive to the presence of NaI, suggesting that covalently bound ligands protect the NP from halide adsorption. In addition, peptide [M − H]− ion yields are significantly higher from AuNPs treated with oxyanions (NO3− and SO42−); however, thiolate-functionalized AuNPs do not show increased negative ion yields, suggesting that these ligands also protect the NP surface from oxyanion physisorption. These studies clearly illustrate the sensitivity of AuNPs to the presence of passivating impurities.
Folding of thermolysin fragments (1985)

Circular dichroism (CD) and immunochemical measurements have been used to examine conformational properties of COOH‐terminal fragments 121–316, 206–316 and 225(226)–316 of thermolysin, and to compare these properties to those of native thermolysin and thermolysin S, the stable partially active two‐fragment complex composed of fragments 5–224(225) and 225(226)–316. In aqueous solution at neutral pH, all the COOH‐terminal fragments attain a native‐like conformation, as judged both by the content of secondary structure deduced from far‐ultraviolet CD spectra and by the recognition of rabbit polyclonal antibodies specific for the COOH‐terminal region in native thermolysin. The three fragments showed reversible cooperative unfolding transitions mediated by both heat and guanidine hydrochloride (Gdn · HCl). The phase transition curves were analyzed for T m (temperature of half‐denaturation) and Gibbs free energies (Δ G D ) of unfolding from native to denatured state. The observed order of thermal stability is 225(226)–316 ≤ 206–316 &lt; 121–316 &lt; thermolysin S &lt; thermolysin. The ranking of Δ G D values for the three fragments correlates with the size of each fragment. Competitive binding studies by radioimmunoassay using 14 C‐labeled thermolysin and affinity purified antibodies specific for native antigenic determinants in segment 206–316 of native thermolysin indicate that the COOH‐terminal fragments adopt native‐like conformations which are in equilibrium with non‐native conformations. These equilibria are shifted towards the native state as the fragment size increases from 225(226)–316, to 206–316, to 121–316. Fragment 225(226)–316, when combined with fragment 5–224(225) in the thermolysin S complex, adopts a more stable native‐like conformation and becomes much more antigenic. It has been shown that the degree of antigenicity of COOH‐terminal fragments towards thermolysin antibodies correlates directly with their conformational stability. The results of this study are discussed in relation to the recently proposed correlation between antigenicity and segmental mobility of globular proteins.
Evaluation of the API 20 c microtube system for the identification of clinically important yeasts (1976)

The API 20 C microtube system containing 20 biochemical tests for the identification of yeasts was compared with conventional tests used in the Mayo Clinic mycology laboratory. Three hundred isolates of clinically important yeasts were studied, and agreement of the carbohydrate fermentation and assimilation tests between the systems was good. The API 20 C represents a useful, commercially available screening method for the identification of yeasts; however, it is not a complete system and must be used in conjunction with microscopic morphological features and, when appropriate, with other biochemical tests.
Wavelet Coding of Volumetric Medical Datasets (2002)

Several techniques based on the 3D Discrete Cosine Transform (DCT) have been proposed for volumetric data coding. These techniques fail to provide lossless coding coupled with quality and resolution scalability, which is a significant drawback for medical applications. This paper gives an overview of several state-of-the-art 3D wavelet coders that do meet these requirements, and proposes new compression methods exploiting the quadtree and block-based coding concepts, layered zero-coding principles and context-based arithmetic coding. Additionally, a new 3D DCT-based coding scheme is designed, and used for benchmarking. The proposed wavelet-based coding algorithms produce embedded data streams that can be decoded up to the lossless level, and support the desired set of functionality constraints. Moreover, objective and subjective quality evaluation on various medical volumetric datasets shows that the proposed algorithms provide competitive lossy and lossless compression results when compared to the state-of-the-art. Index Terms Volumetric coding, medical image compression, lossless compression, embedded coding, quadtree coding, layered zero coding, progressive image transmission, JPEG2000.
Invited editorial (1999)

Parc, Rolland M.D.1; Hida, Jin-ichi M.D.2; Yasutomi, Masayuki M.D.2; Maruyama, Takamasa M.D.2; Tokoro, Tadao M.D.2; Uchida, Toshihiro M.D.2; Wakano, Tsukasa M.D.2; Kubo, Ryuichi M.D.2 Author Information
The design of the normal aortic valve (1981)

The design parameters of the natural aortic valve in vivo were not known, which may explain why various bioprosthetic valves have been designed differently. The design of the aortic valve was studied in vivo by placing radiopaque markers in the valve. The marker movement revealed that, during a cardiac cycle, the design parameters of the valve were changing continuously with changing aortic pressure and ventricular geometry. During diastole decreasing radius of the commissures (Rc) and increasing radius of the bases (Rb) caused the leaflets to tilt toward the ventricle, thereby decreasing the bottom surface angle (alpha) and increasing the free-edge angle (phi) of the leaflet. During systole Rc increased, Rb decreased, and interleaflet distance decreased, causing a change in the geometry of the open valve from conical to cylindrical. In middiastole the design parameters were Rb/Rc = 1.2, H/Rc = 1.4, phi = 34 degrees, and alpha = 20 degrees, where H is sinus height. How a significant deviation from the design could compromise the efficiency and longevity of the valve is discussed.
Palifermin Reduces the Incidence of Oral Mucositis in Patients With Metastatic Colorectal Cancer Treated With Fluorouracil-Based Chemotherapy (2006)

Palifermin administered at the indicated dosing regimen (40 microg/kg for 3 consecutive days) before chemotherapy was well tolerated and resulted in a statistically significant and clinically meaningful reduction in the incidence of WHO grade 2 or higher OM in patients with metastatic CRC.