gebhart/patrepeval huggingface dataset:
In vitro toxicity and efficacy of verdinexor, an exportin 1 inhibitor, on opportunistic viruses affecting immunocompromised individuals (2018)

Infection of immunocompromised individuals with normally benign opportunistic viruses is a major health burden globally. Infections with viruses such as Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), Kaposi's sarcoma virus (KSHV), adenoviruses (AdV), BK virus (BKPyV), John Cunningham virus (JCPyV), and human papillomavirus (HPV) are significant concerns for the immunocompromised, including when these viruses exist as a co-infection with human immunodeficiency virus (HIV). These viral infections are more complicated in patients with a weakened immune system, and often manifest as malignancies resulting in significant morbidity and mortality. Vaccination is not an attractive option for these immune compromised individuals due to defects in their adaptive immune response. Verdinexor is part of a novel class of small molecules known as SINE (Selective Inhibitor of Nuclear Export) compounds. These small molecules demonstrate specificity for the nuclear export protein XPO1, to which they bind and block function, resulting in sequestration of XPO1-dependent proteins in the nucleus of the cell. In antiviral screening, verdinexor demonstrated varying levels of efficacy against all of the aforementioned viruses including previously with HIV. Studies by other labs have discussed likely mechanisms of action for verdinexor (ie. XPO1-dependence) against each virus. GLP toxicology studies suggest that anti-viral activity can be achieved at a tolerable dose range, based on the safety profile of a previous phase 1 clinical trial of verdinexor in healthy human volunteers. Taken together, these results indicate verdinexor has the potential to be a broad spectrum antiviral for immunocompromised subjects for which vaccination is a poor option.
Language and social/emotional problems identified at a universal developmental assessment at 30 months (2013)

Universal assessment of neurodevelopmental function at 30 months identified a significant proportion of children, including those previously considered at low risk, with both language and social/emotional difficulties. Further work is required to assess the precise nature of these difficulties and to assess the potential impact on services.
Stoichiometry of Fluorotopaz and of Mullite Made from Fluorotopaz (1994)

Mixtures of alumina and silica containing 68–78 wt% alumina react above 600°C with 0.5 mol of SiF 4 per mole of alumina to form fluorotopaz. High‐resolution X‐ray powder diffraction data were used to determine very accurate cell parameters of fluorotopaz as a function of 1 wt% compositional increments. The samples containing 69–76 wt% A1 2 O 3 were found to have a linear cell parameter relationship. Compositions outside that range show discontinuities in the cell parameters, indicating solid solution behavior between 69 and 76 wt% alumina. Within this range the composition of fluorotopaz may be written 2A1 2 O 3 · x SiO 2 · SiF 4 where 1.07 x 1.53. Pyrolysis of all compositions of fluorotopaz solid solution yields mullite whiskers containing 76.1 wt% alumina (65.2 mol%).
<title>Recent progress in the development of ISO 19751</title> (2006)

A small number of general visual attributes have been recognized as essential in describing image quality. These include micro-uniformity, macro-uniformity, colour rendition, text and line quality, gloss, sharpness, and spatial adjacency or temporal adjacency attributes. The multiple-part International Standard discussed here was initiated by the INCITS W1 committee on the standardization of office equipment to address the need for unambiguously documented procedures and methods, which are widely applicable over the multiple printing technologies employed in office applications, for the appearance-based evaluation of these visually significant image quality attributes of printed image quality. <sup>1,2</sup> The resulting proposed International Standard, for which ISO/IEC WD 19751-1<sup>3</sup> presents an overview and an outline of the overall procedure and common methods, is based on a proposal that was predicated on the idea that image quality could be described by a small set of broad-based attributes.<sup>4</sup> Five <i>ad hoc </i>teams were established (now six since a sharpness team is in the process of being formed) to generate standards for one or more of these image quality attributes. Updates on the colour rendition, text and line quality, and gloss attributes are provided.
Expression of a foreign gene in a line of transgenic mice is modulated by a chromosomal position effect. (1990)

Unusual aberrant expression of a foreign gene in a particular transgenic mouse line is often attributed to chromosomal position effect, although proof of this is lacking. An alternative explanation is that expression has been modified by the arrangement of multiple copies of the foreign gene at the insertion site or by mutation or gene rearrangement. We have distinguished between these explanations in the case of one particular transgenic line by recovering the aberrantly expressed foreign DNA and reintroducing it into the mouse genome to produce secondary transgenic mice. The expression pattern of the gene in the secondary transgenic mice was normal, showing that this case of aberrant expression is due to a chromosomal position effect.
Treatment of Acromegaly with Bromocriptine (1979)

Five men and three women with active acromegaly were treated with bromocriptine. After three months' therapy (30 mg/day) mean GH during the day decreased by 50% in six out of eight subjects. In the remaining two subjects (non-responders) GH was persistently over 100 micrograms/l. Mean GH during glucose tolerance test were not significantly decreased in three out of the eight subjects, of whom two were the nonresponders. The minimum dose of bromocriptine required to achieve maximum GH suppression ranged from 7.5 to 20 mg/day. In contrast, serum prolactin (PRL) throughout the day suppressed significantly in all subjects after 5 mg/day bromocriptine. Decreases in clinical symptoms, hand volume, urinary hydroxyproline and calcium excretion were seen in about half of the subjects. Three of the four subjects with diabetes mellitus showed improvement in glucose tolerance. Although minor side effects were uncommon, one patient died because of massive gastrointestinal haemorrhage from a duodenal ulcer.
Anti-Idiotypic Antibody as a Mirror Image of the Paratope of the Original Antibody (1987)

Immunization with 2,4-dinitrophenyl-keyhole limpet hemocyanin (DNP-KLH) produced antibodies with combining sites (paratope) which could accommodate not only the 2,4,6-trinitrophenyl (TNP) antigen but also the 4-hydroxy-3-nitrophenyl (NP) and 4-hydroxy-5-iodo-3-nitrophenyl (NIP) antigens, while immunization with NIP-KLH or TNP-KLH produced antibodies with combining sites which could accommodate only the homologous antigens. Utilizing these cross-reacting anti-hapten antibodies mentioned above, an anti-idiotypic antibody was investigated and characterized. Anti-DNP antibodies (Ab1) cross-reacted with the epitopes TNP, NP or NIP. It was also shown that heterologous anti-anti-DNP antibodies (Ab2) recognized not only the antibody which was produced by immunization with DNP-KLH, but also the antibodies produced by immunization with NIP-KLH, NP-KLH or TNP-KLH. The guinea pig anti-idiotypic antibody which we obtained using murine anti-DNP antibodies (Ab1) as antigen is therefore better defined not as an internal image of the antigen but as a mirror image of the paratope of the immunizing Ab1.
Evaluation of experimental spinal cord injury by measuring spontaneous spinal cord potentials (1978)

The relationship between the spontaneous spinal electrogram and the degree of spinal cord injury was studied in anesthetic-free, surgically decerebrate cats that received experimental blunt trauma by the graded weight-drop method. It was found that the characteristic spontaneous slow negative potential of the spinal electrogram showed a frequency dependency that correlated positively with the intensity of the injury (impulse expressed in gm-sec). Graphs of the frequency of occurrence of the slow negative potentials as a function of time following initial injury indicated that both the slope and shape of the curve were dependent on the severity of the injury measured in gm-sec at the time of the injury and confirmed histologically. These results indicate that the spontaneous spinal electrogram may serve as a sensitive indicator of the degree of spinal cord injury and may be useful in the assessment of various treatment modalities.
Diferencias intraespecíficas en el uso de un vertedero por parte de la Cigüeña Blanca (Ciconia ciconia) en el oeste de la Península Ibérica (1998)

Es va estudiar la presencia de cigonyes blanques anellades a l'abocador de Caceres durant les temporades de cria de 1989 i 1990. La mitjana mes alta del nombre d'ocells es va donar durant l'abril, mentre que al maig va ser el mes amb el menor nombre d'ocells. Els exemplars mes joves de quatre anys foren mes frequents i amb proporcions majors del que s'esperava tenint en compte els percentatges de mortalitat d'aquesta especie. Entre els ocells mes joves de quatre anys els mes abundants foren els individus d'un any, els quals eren mes frequents de l'esperat. Durant el periode d'estudi les cigonyes van estar a l'abocador el mateix temps amb independencia de les dues classes d'edats definides. Aquests resultats mostren la importancia del menjar addicional per als ocells immadurs.
LCOS Spatial Light Modulators: Trends and Applications (2012)

This chapter contains sections titled: Introduction LCOS-Based SLMs Some Applications of Spatial Light Modulators in Optical Imaging and Metrology Conclusion References
Two-Level Volt/Var Control Strategy in Distribution Networks with Intermittent Renewables (2018)

This paper proposes a two-level Volt/Var control strategy in distribution networks considering the integration of intermittent renewables. It combines central and local control schemes. The central control collects loads and distributed generation (DG) measurements to optimize reactive power set-point of DG units to keep voltages within allowable limits. In addition, the central control uses a scenario-based approach to optimize local control parameters. This strategy considers the uncertainty related to photovoltaic (PV) systems, which is applied to a radial distribution feeder with high PV penetration. Simulation results verify the effectiveness of the proposed strategy in regulating voltage within limits and dealing with the fluctuation of DGs.
Rotaviruses in infants with diarrhea studied by viral RNA electrophoresis in Ankara, Turkey. (1989)

Incidence of rotavirus in children under 2 years of age, admitted to 2 children's hospitals i n Ankara, Turkey, from July 1984-June 1985 was measured using viral RNA electrophoresis in agarose gels. 375 children were selected at random from over 14,000 diarrhea admissions, and their stool specimens taken on admission were compared to those of 333 children without diarrhea. 61 (16.3%) of the diarrhea cases had detectable rotavirus, compared to 0% in controls. Bacteriologic tests for salmonella, Shigella and Campylobacter jejuni were positive for 51 (13.6%) of the diarrhea patients and 1.8% of controls. 1 child had both rotavirus and Salmonella. Rotavirus infection was highest in November- March, peaking in December. Bacterial diarrhea was prevalent in the summer. This pattern is typical of a temperate climate, although in developed countries bacterial gastroenteritis is not as prevalent. Since there are about 2340 diarrhea admissions annually for rotavirus in Ankara, from a population of 2,700,000, rotavirus vaccination seems appropriate.
Multiplexing of interferometric sensors using phase carrier techniques (1987)

This paper demonstrates the multiplexing of fiber-optic interferometric sensors using a CW phase generated carrier technique. The technique employs modulated diode laser sources at different carrier frequencies, nearly balanced interferometers (∼4-cm path difference), and phase generated carrier demultiplexing demodulation. This approach leads to a simple all-passive sensor array which has intrinsically low crosstalk. The system is analyzed in terms of shot noise performance and crosstalk. An experimental all optical implementation of a four sensor array was demonstrated; both the single sensor and multisensor arrays were limited by the laser phase noise to a sensitivity of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\sim 18 \mu</tex> rad/ <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\sqrt{Hz}</tex> . Crosstalk between individual channels was better than -60 dB and crosstalk between three sensors and the test sensor was better than -55 dB. In the absence of laser phase noise the demodulator/demultiplexer demonstrated <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\sim 2-\mu</tex> rad performance with both single sensor and four element array operation.
Organic Anion Transporting Polypeptide 2B1 in Human Fetal Membranes: A Novel Gatekeeper for Drug Transport During Pregnancy? (2021)

Current intervention strategies have not been successful in reducing the risks of adverse pregnancy complications nor maternal and fetal morbidities associated with pregnancy complications. Improving pregnancy and neonatal outcomes requires a better understanding of drug transport mechanisms at the feto-maternal interfaces, specifically the placenta and fetal membrane (FM). The role of several solute carrier uptake transporter proteins (TPs), such as the organic anion transporting polypeptide 2B1 (OATP2B1) in transporting drug across the placenta, is well-established. However, the mechanistic role of FMs in this drug transport has not yet been elucidated. We hypothesize that human FMs express OATP2B1 and functions as an alternate gatekeeper for drug transport at the feto-maternal interface. We determined the expression of OATP2B1 in term, not-in-labor, FM tissues and human FM cells [amnion epithelial cell (AEC), chorion trophoblast cell (CTC), and mesenchymal cells] using western blot analyses and their localization using immunohistochemistry. Changes in OATP2B1 expression was determined for up to 48 h after stimulation with cigarette smoke extract (CSE), an inducer of oxidative stress. The functional role of OATP2B1 was determined by flow cytometry using a zombie violet dye substrate assay. After OATP2B1 gene silencing, its functional relevance in drug transport through the feto-maternal interface was tested using a recently developed feto-maternal interface organ-on-a-chip (OOC) system that contained both FM and maternal decidual cells. Propagation of a drug (Rosuvastatin, that can be transported by OATP2B1) within the feto-maternal interface OOC system was determined by mass spectrometry. FMs express OATP2B1 in the CTC and AEC layers. In FM explants, OATP2B1 expression was not impacted by oxidative stress. Uptake of the zombie violet dye within AECs and CTCs showed OATP2B1 is functionally active. Silencing OATP2B1 in CTCs reduced Rosuvastatin propagation from the decidua to the fetal AEC layer within the feto-maternal interface-OOC model. Our data suggest that TPs in FMs may function as a drug transport system at the feto-maternal interface, a function that was previously thought to be performed exclusively by the placenta. This new knowledge will help improve drug delivery testing during pregnancy and contribute to designing drug delivery strategies to treat adverse pregnancy outcomes.
Distributed Algorithms for Optimal Rate-Reliability Tradeoff in Networks (2005)

The current framework of network utility maximization for distributed rate allocation assumes fixed channel code rates. However, by adapting the physical layer channel coding, different rate-reliability tradeoffs can be achieved on each link and for each end user. Consider a network where each user has a utility function that depends on both signal quality and data rate, and each link may provide a `fatter' (`thinner') information `pipe' by allowing a higher (lower) decoding error probability. We propose two distributed, pricing-based algorithms to attain optimal rate-reliability tradeoff, with an interpretation that each user provides its willingness to pay for reliability to the network and the network feeds back congestion prices to users. The proposed algorithms converge to a tradeoff point between rate and reliability, which is proved to be globally optimal for codes with sufficiently large codeword lengths and user utilities with sufficiently negative curvatures.
From lab to fab: how must the polymer solar cell materials design change? – an industrial perspective (2013)

Organic photovoltaic (OPV) devices, in particular polymer solar cells, made by solution processed organic materials have shown great promise as a disruptive technology for affordable electricity. Even though recent advances look impressive on paper, until now the commercialization of OPV has been hampered by the difficulty of converting lab produced “champion” cell figures into reliable industrial-scale product performances. A key factor to achieve this condition is to develop OPV materials (polymer donors, acceptors, buffer materials, electrodes materials and encapsulants) exhibiting the required technical and economic characteristics to be conveniently used in an industrial environment. The well established strategies for the design of materials for efficient lab-scale OPV devices are not sufficient when large-area printed panels are concerned. A number of additional requirements, normally not addressed in the laboratory context, must be met: the materials must be easily accessible as pure compounds in few synthetic steps from cheap starting compounds, need to be stable and soluble enough to afford ink formulations processable with roll-to-roll compatible equipment; solvent and solvent additives should be easily removable after printing, and possibly should be environmentally friendly compounds; the layers should achieve a stable morphology under mild conditions (low temperatures and short times); the above mentioned materials can be screened on glass substrates, but should be finally tested on plastic films, protected through a scalable encapsulation technique. The more researchers adhere to these guidelines, the greater the possibility for OPV to demonstrate at last its enormous potential on the industrial scale.
Intermolecular control of thermoswitching and photoswitching phenomena in two spin-crossover polymorphs (2012)

We discuss here the important role of intermolecular coupling for the thermal- and light-induced molecular state switching in the solid state. Investigations were performed on the two crystalline polymorphs of the spin-crossover [Fe-(PM-BIA)${}_{2}$(NCS)${}_{2}$] material. In addition to structural studies at thermal equilibrium, light-induced phenomena were investigated through photocrystallography, photomagnetic, and dynamical optical measurements. Strong similarities between the thermal-equilibrium and the out-of-equilibrium light-induced transformations are observed in each polymorph: strong cooperative phenomena in one polymorph versus weak cooperative ones in the second polymorph. These different responses of the two crystalline forms of the compound to external perturbations are discussed at the microscopic level in terms of Ising-like model and two-mode description of on-site molecular potentials.
The genetic fingerprint of susceptibility for transplant-associated thrombotic microangiopathy (2015)

Transplant-associated thrombotic microangiopathy (TA-TMA) occurs frequently after hematopoietic stem cell transplantation (HSCT) and can lead to significant morbidity and mortality. There are no data addressing individual susceptibility to TA-TMA. We performed a hypothesis-driven analysis of 17 candidate genes known to play a role in complement activation as part of a prospective study of TMA in HSCT recipients. We examined the functional significance of gene variants by using gene expression profiling. Among 77 patients undergoing genetic testing, 34 had TMA. Sixty-five percent of patients with TMA had genetic variants in at least one gene compared with 9% of patients without TMA (P < .0001). Gene variants were increased in patients of all races with TMA, but nonwhites had more variants than whites (2.5 [range, 0-7] vs 0 [range, 0-2]; P < .0001). Variants in ≥3 genes were identified only in nonwhites with TMA and were associated with high mortality (71%). RNA sequencing analysis of pretransplantation samples showed upregulation of multiple complement pathways in patients with TMA who had gene variants, including variants predicted as possibly benign by computer algorithm, compared with those without TMA and without gene variants. Our data reveal important differences in genetic susceptibility to HSCT-associated TMA based on recipient genotype. These data will allow prospective risk assessment and intervention to prevent TMA in highly susceptible transplant recipients. Our findings may explain, at least in part, racial disparities previously reported in transplant recipients and may guide treatment strategies to improve outcomes.
The role of the potential surface in transport and relaxation phenomena in the He–H2 system (1991)

This paper examines the role of the potential surface of the rigid rotor He–H2 system upon a variety of transport and relaxation cross sections, including some involving field effects. The technique of functional sensitivity analysis is used to explore these issues. Three different levels of cross sections were studied: microscopic, thermally averaged, and effective cross sections. The cross sections studied were found to be sensitive to differing components of the potential energy surface, with some cross sections being more sensitive to either the slope or the magnitude of the potential components. The degree of information loss in the progression from microscopic to bulk observables is highly dependent on the individual phenomenon.
Important role of muscle carnosine in rowing performance (2010)

The role of the presence of carnosine (β-alanyl-L-histidine) in millimolar concentrations in human skeletal muscle is poorly understood. Chronic oral β-alanine supplementation is shown to elevate muscle carnosine content and improve anaerobic exercise performance during some laboratory tests, mainly in the untrained. It remains to be determined whether carnosine loading can improve single competition-like events in elite athletes. The aims of the present study were to investigate if performance is related to the muscle carnosine content and if β-alanine supplementation improves performance in highly trained rowers. Eighteen Belgian elite rowers were supplemented for 7 wk with either placebo or β-alanine (5 g/day). Before and following supplementation, muscle carnosine content in soleus and gastrocnemius medialis was measured by proton magnetic resonance spectroscopy ((1)H-MRS) and the performance was evaluated in a 2,000-m ergometer test. At baseline, there was a strong positive correlation between 100-, 500-, 2,000-, and 6,000-m speed and muscle carnosine content. After β-alanine supplementation, the carnosine content increased by 45.3% in soleus and 28.2% in gastrocnemius. Following supplementation, the β-alanine group was 4.3 s faster than the placebo group, whereas before supplementation they were 0.3 s slower (P = 0.07). Muscle carnosine elevation was positively correlated to 2,000-m performance enhancement (P = 0.042 and r = 0.498). It can be concluded that the positive correlation between baseline muscle carnosine levels and rowing performance and the positive correlation between changes in muscle carnosine and performance improvement suggest that muscle carnosine is a new determinant of rowing performance.