gebhart/patrepeval huggingface dataset:
Cyclin E mRNA: Assessing Cyclin-Dependent Kinase (CDK) Activation State to Elucidate Breast Cancer Resistance to CDK4/6 Inhibitors (2019)

The treatment of estrogen receptor (ER)-positive metastatic breast cancer has been dramatically transformed through the introduction of ATPcompetitive inhibitors of the cyclin-dependent kinases 4 and 6 (CDK4/6i) in combination with antiestrogen therapies.Seven phase III studies demonstrated clear improvements in progression-free survival through the addition of these agents in either the firstor later-line setting, with new studies underway to evaluate the benefit of these agents as adjuvant therapy. 1-7A core scientific premise backing these agents is that in a large subset of tumors, ER inhibition is only partially effective at blocking the G1 checkpoint kinases CDK4/ 6, either because of ineffective ER inhibition (eg, ESR1 mutations) 8-10 or hormone-independent inputs into CDK4/6 activation (eg, NF1 loss). 11The addition of highly selective CDK4/6 kinase inhibitors enables more potent and durable blockade of the cell cycle, which may accrue additional benefits such as inducing tumor cell senescence or augmenting antitumor immunity.2][3][4][5][6][7] Even with such great clinical heterogeneity, there remain virtually no biomarkers to separate these subgroups of patients.This is particularly poignant given the potential efficacy of alternative forms of therapy in ER-positive metastatic breast cancer, including mammalian target of rapamycin inhibition (everolimus) 12 as well as chemotherapy.In the companion article, Turner et al 13 use pretreatment tumor samples from the PALOMA-3 (Palbociclib [PD-0332991] Combined With Fulvestrant In Hormone Receptor1 HER2-Negative Metastatic Breast Cancer After Endocrine Failure) trial of fulvestrant versus fulvestrant plus palbociclib to investigate biomarkers that may identify tumors that are de novo resistant to the fulvestrant plus palbociclib combination and, specifically, find high levels of cyclin E1 (CCNE1) associated with an attenuated benefit.
Effect of dietary calcium or phosphorus restriction and 1,25-dihydroxyvitamin D administration on rat intestinal 24-hydroxylase. (1992)

1,25-Dihydroxyvitamin D-24-hydroxylase (24-hydroxylase) modulates the biological effects of 1,25-dihydroxyvitamin D [1,25-(OH)2D] in tissues. The presence of 24-hydroxylase in intestinal mucosa and the mass of the intestine suggest that the intestine is a major site of catabolism of 1,25-(OH)2D. How intestinal levels of 24-hydroxylase are regulated under various dietary conditions, such as calcium (Ca) or phosphorus (P) restriction, is poorly understood. In a series of trials on weanling and mature rats, the effects of dietary Ca or P restriction were compared with the effects of exogenous 1,25-(OH)2D3 administration on intestinal 24-hydroxylase activity. Exogenous administration of 1,25-(OH)2D3, by single bolus injection or constant infusion, increased intestinal 24-hydroxylase activity significantly. Dietary Ca and P restriction both resulted in increased plasma 1,25-(OH)2D3 concentrations several-fold above control rat values (P less than 0.001) and to levels higher than those achieved by constant infusion of 1.3 ng 1,25-(OH)2D3/h. Dietary Ca restriction increased intestinal 24-hydroxylase 6- to 20-fold above that of rats fed a Ca-replete diet (P less than 0.001). Dietary P restriction had no significant effect on intestinal 24-hydroxylase activity. These data suggest that dietary Ca restriction results in increased plasma levels of 1,25-(OH)2D3, which, in turn, leads to up-regulation of intestinal 24-hydroxylase. Conversely, dietary P restriction prevents 1,25-(OH)2D3-mediated up-regulation of 24-hydroxylase.
Zirconium Oxide based memristors fabrication via Electrohydrodynamic Printing (2020)

There has been great research interest for memristors worldwide as it has many potential applications. Resistive memories based on metal oxide thin films have been extensively studied for application as next generation nonvolatile memory devices since they have several advantages, such as good scalability, low-power consumption, and fast switching speed. However, the fabrication of metal oxide based memristors usually consists of conventional physical vapor deposition (PVD) techniques and lithography which are expensive, time consuming and complicated in nature. In this paper, we report the successful fabrication of ZrO2 based memristor using electrospray deposition (ESD) and electrohydrodynamic printing (EHDP) techniques which are cost-effective, room temperature techniques. The Ag electrode has been patterned on glass substrates through EHDP technique and the active layer of ZrO2 has been spray deposited on the Ag electrode followed by the patterning of top Ag electrode. The resistive switching properties of ZrO2 layer with Ag electrodes was investigated in this study.
Dual Signaling Regulated by Calcyon, a D1 Dopamine Receptor Interacting Protein (2000)

The synergistic response of cells to the stimulation of multiple receptors has been ascribed to receptor cross talk; however, the specific molecules that mediate the resultant signal amplification have not been defined. Here a 24-kilodalton single transmembrane protein, designated calcyon, we functionally characterize that interacts with the D1 dopamine receptor. Calcyon localizes to dendritic spines of D1 receptor-expressing pyramidal cells in prefrontal cortex. These studies delineate a mechanism of Gq- and Gs-coupled heterotrimeric GTP-binding protein-coupled receptor cross talk by which D1 receptors can shift effector coupling to stimulate robust intracellular calcium (Ca2+i) release as a result of interaction with calcyon. The role of calcyon in potentiating Ca2+-dependent signaling should provide insight into the D1 receptor-modulated cognitive functions of prefrontal cortex.
A dynamic system bandwidth control scheme for multilayered cellular system with different bandwidths (1999)

A multilayered cellular system using cell overlay structure is proposed for land mobile communications, which offers a high subscriber capacity and is expected to realize a communication system that can handle the terminal movement flexibly. In the microcell environment, the effect of delayed waves is less pronounced, and the usual approach is to assign a channel with a wider bandwidth than in the macrocell and to realize high-speed transmission. This paper considers a multilayered system with different bandwidths under such an assignment, and proposes a system which realizes excellent transmission characteristics as a whole, by optimally assigning the system bandwidth according to the traffic situation. The performance of the system is examined by computer simulation. © 1999 Scripta Technica, Electron Comm Jpn Pt 1, 83(1): 63–72, 2000
Epitaxial ferroelectric Ba0.5Sr0.5TiO3 thin films for room-temperature tunable element applications (1999)

Perovskite Ba0.5Sr0.5TiO3 thin films have been synthesized on (001) LaAlO3 substrates by pulsed laser ablation. Extensive x-ray diffraction, rocking curve, and pole-figure studies suggest that the films are c-axis oriented and exhibit good in-plane relationship of 〈100〉BSTO//〈100〉LAO. Rutherford backscattering spectrometry studies indicate that the epitaxial films have excellent crystalline quality with an ion beam minimum yield χmin of only 2.6%. The dielectric property measurements by the interdigital technique at 1 MHz show room-temperature values of the relative dielectric constant, εr, and loss tangent, tan δ, of 1430 and 0.007 with no bias, and 960 and 0.001 with 35 V bias, respectively. The obtained data suggest that the as-grown Ba0.5Sr0.5TiO3 films can be used for development of room-temperature tunable microwave elements.
Hyperacute Lung Rejection in the Pig-to-Human Model 4: Evidence for Complement and Antibody Independent Mechanisms (2005)

Depletion of xenoreactive antibodies is more effective than membrane-bound complement regulation to blunt hyperacute rejection of pulmonary xenografts, but even the combined approach including soluble-phase complement inhibition is not sufficient to reliably prevent organ failure within hours. It therefore seems likely that other factors independent of antibody and complement contribute to HAR in this model.
Compound Ex Vivo and In Silico Method for Hemodynamic Analysis of Stented Arteries (2013)

Hemodynamic factors such as low wall shear stress have been shown to influence endothelial healing and atherogenesis in stent-free vessels. However, in stented vessels, a reliable quantitative analysis of such relations has not been possible due to the lack of a suitable method for the accurate acquisition of blood flow. The objective of this work was to develop a method for the precise reconstruction of hemodynamics and quantification of wall shear stress in stented vessels. We have developed such a method that can be applied to vessels stented in or ex vivo and processed ex vivo. Here we stented the coronary arteries of ex vivo porcine hearts, performed vascular corrosion casting, acquired the vessel geometry using micro-computed tomography and reconstructed blood flow and shear stress using computational fluid dynamics. The method yields accurate local flow information through anatomic fidelity, capturing in detail the stent geometry, arterial tissue prolapse, radial and axial arterial deformation as well as strut malapposition. This novel compound method may serve as a unique tool for spatially resolved analysis of the relationship between hemodynamic factors and vascular biology. It can further be employed to optimize stent design and stenting strategies.
Beyond MPI (2021)

Networkswith Remote DirectMemoryAccess (RDMA) support are becoming increasingly common. RDMA, however, offers a limited programming interface to remote memory that consists of read, write and atomic operations. With RDMA alone, completing the most basic operations on remote data structures often requires multiple round-trips over the network. Data-intensive systems strongly desire higher-level communication abstractions that supportmore complex interaction patterns. A natural candidate to consider is MPI, the de facto standard for developing high-performance applications in the HPC community. This paper critically evaluates the communication primitives of MPI and shows that using MPI in the context of a data processing system comes with its own set of insurmountable challenges. Based on this analysis, we propose a new communication abstraction named RDMO, or Remote DirectMemory Operation, that dispatches a short sequence of reads, writes and atomic operations to remote memory and executes them in a single round-trip.
TRANSLATING OODB METHOD TO RDB ROUTINE (2001)

A methodology is introduced for translating from methods in an object-oriented database to routines in a relational database. The approach consists of three steps. The first step is to translate method signature to Persistent Stored Modules signature. The second step is to translate method source language to (function/procedure) routine. The process includes Host Language, OSQL's Qualification, Query Translation, Update Transaction Translation, and Objects inside Object. The third step is to translate method invocation to routine invocation. According to this approach, object-oriented database methods can be translated to relational database routines that can be executed in the relational database environment assisted by a frame model and case statements listing all possible cases of binding conditions and actions. The significance of the finding is adding an open object-oriented interface on top of relational database system for database interoperability and in the development of an object-relational database management system.
Effect of Precursor Entrance Sequence during Atomic Layer Deposition on the Al2O3/Ge Interface by X-ray Photoelectron Spectroscopy (2013)

The effect of precursor entrance sequence during atomic layer deposition (ALD) on the chemical and electronic characteristics of Al 2 O 3 /Ge interface is investigated by X-ray photoelectron spectroscopy (XPS) and capacitance-voltage (C-V) measurement. The trimethyla-luminium (TMA) or H 2 O precursor is first introduced into the chamber to grow Al 2 O 3 dielectric on cleaned Ge. An abrupt Al 2 O 3 /Ge interface without interlayer is obtained for both cases. The valence band offset (VBO) at the Al 2 O 3 /Ge interface becomes smaller when the TMA precursor is first introduced. It is due to the lower CNL of gap states at Al 2 O 3 /Ge interface which is induced by the TMA treatment of Ge surface. Comparable gap state density at Al 2 O 3 /Ge interface are observed by C-V, indicating that the density states of gap states is not affected by the precursor pulse sequence. As a result, the precursor pulse sequence affects the CNL of gap states but not their density.
Performance comparison of modulation formats for 40 Gbit/s DWDM transmission systems (2005)

The performance of various modulation formats, namely OOK, DPSK and DQPSK with and without RZ carving, were experimentally compared to clarify the optimum modulation formats for 40 Gbit/s DWDM transmission systems with 50 GHz channel spacing.
Embodied Collaborative Referring Expression Generation in Situated Human-Robot Interaction (2015)

To facilitate referential communication between humans and robots and mediate their differences in representing the shared environment, we are exploring embodied collaborative models for referring expression generation (REG). Instead of a single minimum description to describe a target object, episodes of expressions are generated based on human feedback during human-robot interaction. We particularly investigate the role of embodiment such as robot gesture behaviors (i.e., pointing to an object) and human's gaze feedback (i.e., looking at a particular object) in the collaborative process. This paper examines different strategies of incorporating embodiment and collaboration in REG and discusses their possibilities and challenges in enabling human-robot referential communication.
Alpha chymotrypsin coated clusters of Fe3O4nanoparticles for biocatalysis in low water media (2012)

A strategy for obtaining a high activity preparation of alpha chymotrypsin for application in low water media is described. Such high activity biocatalysts are useful in organic synthesis.
Prevalence of glaucoma in the elderly population in Taiwan: The Shihpai Eye Study (2020)

Glaucoma is prevalent in the elderly population in Taiwan, but the diagnostic rate and disease awareness are low. Since most subjects with glaucoma presented with normal IOPs, optic disc evaluation is critical for diagnosing glaucoma in the elderly in Taiwan.
Energy Reduction in Consolidated Servers through Memory-Aware Virtual Machine Scheduling (2010)

Increasing energy consumption in server consolidation environments leads to high maintenance costs for data centers. Main memory, no less than processor, is a major energy consumer in this environment. This paper proposes a technique for reducing memory energy consumption using virtual machine scheduling in multicore systems. We devise several heuristic scheduling algorithms by using a memory power simulator, which we designed and implemented. We also implement the biggest cover set first (BCSF) scheduling algorithm in the working server system. Through extensive simulation and implementation experiments, we observe the effectiveness of the memory-aware virtual machine scheduling in saving memory energy. In addition, we find out that power-aware memory management is essential to reduce the memory energy consumption.
Skin Test Reactivity to Mycobacterial Antigens in Patients with Pulmonary Tuberculosis and in Normal Population in Korea (1984)

Hosþital한국인
Per-Tone model for Common Mode sensor based alien noise cancellation for\n Downstream xDSL (2017)

For xDSL systems, alien noise cancellation using an additional common mode\nsensor at the downstream receiver can be thought of as interference\ncancellation in a Single Input Dual Output (SIDO) system. The coupling between\nthe common mode and differential mode can be modelled as an LTI system with a\nlong impulse response, resulting in high complexity for cancellation. Frequency\ndomain per-tone cancellation offers a low complexity approach to the problem\nbesides having other advantages like faster training, but suffers from loss in\ncancellation performance due to approximations in the per-tone model. We\nanalyze this loss and show that it is possible to minimize it by a convenient\npost-training "delay" adjustment. We also show via measurements that the loss\nof cancellation performance due to the per-tone model is not very large for\nreal scenarios.\n
Kinetics and mechanism of the acid-catalyzed aquation and base hydrolysis of nitropentacyanoferrate(III) in aqueous solution. Evidence for a pseudo-zero-order hydrolysis process (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics and mechanism of the acid-catalyzed aquation and base hydrolysis of nitropentacyanoferrate(III) in aqueous solution. Evidence for a pseudo-zero-order hydrolysis processG. Stochel, R. Van Eldik, E. Hejmo, and Z. StasickaCite this: Inorg. Chem. 1988, 27, 16, 2767–2770Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/ic00289a005https://doi.org/10.1021/ic00289a005research-articleACS PublicationsRequest reuse permissionsArticle Views208Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Solid‐phase extraction of matrine and oxymatrine from Sophora Flavescens Ait using amino‐imidazolium polymer (2010)

A new, polymer-confined, ionic liquid sorbent was developed by a process involving polymerization and modification. The obtained particles were successfully used as a special sorbent in SPE process to isolate matrine and oxymatrine from Sophora Flavescens Ait. Different washing and elution solvents, such as ethanol, methanol, acetonitrile and methanol/triethylamine (90:10, v/v), were evaluated. Compared with the C(18) and NH(2) sorbents, the amino-imidazolium polymer sorbent exhibited higher selectivity. Quantitative analysis was carried out by using a C(18) column. The two compounds exhibited good linearity from 5x10(-3) to 0.50 mg/mL (r(2)>0.99). The bound amounts between target compounds and proteins were obtained by this sorbent. After three recycles of amino-imidazolium polymer, the extract amounts of the target compounds were not significantly decreased.
Quantitative Profiling of Phospholipids by Multiple Precursor Ion Scanning on a Hybrid Quadrupole Time-of-Flight Mass Spectrometer (2002)

A hybrid quadrupole time-of-flight mass spectrometer featured with ion trapping capabilities was employed for quantitative profiling of total extracts of endogenous phospholipids. Simultaneous acquisition of precursor ion spectra of multiple fragment ions allowed detection of major classes of phospholipids in a single experiment. Relative changes in their concentration were monitored using a mixture of isotopically labeled endogenous lipids as a comprehensive internal standard. Precursor ion scanning spectra were acquired simultaneously for acyl anions of major fatty acids in negative ion mode and identified the fatty acid moieties and their relative position at the glycerol backbone in individual lipid species. Taken together, a combination of multiple precursor ion scans allowed quantitative monitoring of major perturbation in phospholipid composition and elucidating of molecular heterogeneity of individual lipid species.
A 4.8-6.4-Gb/s serial link for backplane applications using decision feedback equalization (2005)

In this paper, a serial link design that is capable of 4.8-6.4-Gb/s binary NRZ signaling across 40'' of FR4 copper backplane traces and two connectors is described. The transmitter features a programmable two-tap feed forward equalizer and the receiver uses an adaptive four-tap decision feedback equalization to compensate for the losses in the channel at 6.4 Gbps. The transceiver core is built in LSI's 0.13-/spl mu/m standard CMOS technology to be integrated into ASIC designs that require serial links. The transceiver consumes 310 mW per duplex channel at 1.2 V and 6.4 Gb/s under nominal conditions.
Survival Outcomes of Dose-Escalated External Beam Radiotherapy versus Combined Brachytherapy for Intermediate and High Risk Prostate Cancer Using the National Cancer Data Base (2015)

Compared to EBRT (75.6 to 81 Gy) we observed an association of EBRT plus brachytherapy with a decreased risk of death in men with intermediate and high risk prostate cancer. However this association was no longer significant when EBRT doses of 79.2 to 81 Gy were used.
Biologically active cyanobacteria metabolites – Ecological and biomedical perspectives (2008)

The hepatotoxic microcystins are the most frequently monitored toxins in cyanobacteria waterblooms. Microcystins are produced by several genera of cyanobacteria, including Microcystis, Anabeana, Nostoc and Planktothrix (Oscillatoria). More than seventy natural variants of these cyclic peptides are known. The major toxins found in various species of these genera are: microcystin-LR, microcystin-YR, as well as microcystin-RR. The microcystins are stable in the mammalian gastrointestinal system and are absorbed in the gastrointestinal tract, transported to the liver and concentrated there. Within the liver cells, the microcystins, inhibit specific protein phosphatases (PPs), PP1 and PP2, which are key components for the control of the cell structure and function, with IC50's that vary between 0.1 nM and 10 nM. The appearance of toxicity by microcystins depends on the balance between their accumulation and metabolism in the liver. Comparisons of the toxicity of pure microcystins with the toxicity of intact cells from toxic cyanobacteria-blooms, or their crude extracts, suggest that other compounds that accompany the microcystins enhance their activity. The microcystins, are usually accompanied by a considerable amount of protease inhibitors from five different groups, namely – micropeptins, aerugenosins, microginins, anabaenopeptins and microveridins. The biological activity and structure/activity relationships of these groups of protease inhibitors, as well as the relationships between the toxicity of the microcystins and the protease inhibitors and some possible involvement of these metabolites with cyanobacterial bloom collapse, are presented.
NADP‐specific glutamate dehydrogenase of Penicillium chrysogenum has a homohexamer structure (1996)

The NADP-specific glutamate dehydrogenase of a high beta-lactam producing industrial strain of Penicillium chrysogenum was purified to homogeneity. The enzyme (M(r) = 339,000 +/- 34,000) was demonstrated to have a homohexamer quaternary structure with a subunit molecular mass of M(r) = 56,000 +/- 2000. The N-terminal sequence of the enzyme was also determined and was found to be highly homologous to other fungal NADP-specific glutamate dehydrogenase sequences.