gebhart/patrepeval huggingface dataset:
How flies are flirting on the fly (2017)

We describe a previously unrecognized visual mate recognition system in L. sericata. The system depends upon the sex- and age-specific frequencies of light flashes reflecting off moving wings, and the ability of male flies to distinguish between the frequency of light flashes produced by rival males and prospective mates. Our findings imply that insect photoreceptors with fast processing speed may not only support agile flight with advanced maneuverability but may also play a supreme role in mate recognition. The low mating propensity of L. sericata males on cloudy days, when light flashes from the wings of flying females are absent, seems to indicate that these flies synchronize sexual communication with environmental conditions that optimize the conspicuousness of their communication signals, as predicted by sensory drive theory.
Application of Voltammetry for Quantitative Analysis of Actinides in Molten Salts (2015)

Our previous work ("Method Development for Quantitative Analysis of Actinides in Molten Salts" 2015)1 demonstrated that by following a set of developed procedures and a refined data analysis method, cyclic voltammetry can be used for very precise, real-time quantitative concentration measurements of actinides in molten salts. This work examines the suitability of the established procedures over a wider range of concentrations comparable to those expected in the normal operation of an electrorefiner used in the pyrochemical processing of used nuclear fuel. We found that electrochemical methods can be used for very precise concentration measurements up to approximately 2 wt%. For higher actinide concentrations, the value of the diffusion coefficient decreases and these variations have to be taken into consideration. We also investigated the application of voltammetry for analyzing systems containing multiple elements (U3+ and Pu3+) and found that a zero current baseline determination of the second or succeeding peak in the voltammogram is not a correct approach, since that peak is affected by the tail from the peak that preceded it. We then used a different method of data analysis that allows for an accurate baseline determination and can be used to analyze systems involving more than one component.
A Methodology-Oriented Assessment of Digital Phenotyping for Mood Disorders (Preprint) (2022)

<sec> <title>BACKGROUND</title> In the burgeoning area of clinical digital phenotyping research, there is a dearth of literature that details methodology, including the key challenges and dilemmas in developing and implementing a successful architecture for technological infrastructure, patient engagement, longitudinal study participation, and successful reporting and analysis of diverse passive and active digital data streams. </sec> <sec> <title>OBJECTIVE</title> This article provides a narrative rationale for our study design in the context of current evidence base and best practices with an emphasis on our initial lessons learned from the implementation challenges and successes of this study. </sec> <sec> <title>METHODS</title> We describe the specific study methodology we implemented for this study with an attention to synthesizing key literature and the reasoning for pragmatic adaptations in implemenating in a multi-site study encompassing distinct geographic and population settings. </sec> <sec> <title>RESULTS</title> We describe the feasibility of a multi-site digital phenotyping pilot study for patients with mood disorders, focused on the informatics framework for our study, practical learnings about study subject use of our hardware and software tools, and perceived strengths, weaknesses, opportunities, and barriers to success in implementing digital phenotyping research for mood disorders and other psychiatric conditions. </sec> <sec> <title>CONCLUSIONS</title> We leverage our experience with developing a pilot feasibility study to help academic and industry researchers and developers efficiently and effectively conceptualize and operationalize further digital phenotyping investigations in this promising area of mental health research. We believe the methodology described will be readily reproducible and generalizable to other study settings and patient populations. </sec>
ANTROPOLOGIA: INTEGRAÇÃO SERVIÇO, ENSINO, COMUNIDADE (2019)

Este trabalho tem por objetivo calcular a importância das materias Antropologia e Pisec para os profissionais de saude, bem como exemplificar as integracoes entre os mesmo a favor da sociedade. Na introducao fala-se em Diretrizes Curriculares Nacionais (DCN), que sao orientacoes para elaboracao dos curriculos que devem ser necessariamente adotadas por todas as instituicoes de ensino superior, e sobre o Projeto Pedagogico de Curso (PPC) que orienta estrategias a serem utilizadas em determinado curso. Alem disso, define as materias PISEC e ANTROPOLOGIA. O objetivo do trabalho e baseado em analisar o PPC e os planos de Ensino PISEC I/ Antropologia, revisar a literatura e exemplificar integracao entre ensino da disciplina PISEC I/ Antropologia e a prestacao de servicos odontologicos na assistencia a comunidade. Na metodologia foi realizada a solicitacao de documentos e analise critica de cada um deles, a busca bibliografica para revisao de literaturas a partir de livros e artigos, e para que fosse firmado o resultado, realizou-se a identificacao de um exemplo disponivel em publicacao. Foi obtido como resultado da analise dos PPC’s e planos de ensino atraves de uma leitura critica, que eles complementam-se com a intencao de integrar o aluno a pratica no contexto do servico, do ensino e da comunidade associado ao conhecimento antropologico da cultura e sua relacao com a subjetividade. Por meio da revisao de literatura, obteve-se o resultado de que a pratica educativa humanizada inclui os estudantes no processo de construcao da cidadania comprometida e integrada a realidade social e epidemiologica, e oportuniza a formacao profissional contextualizada e transformadora. Dessa forma, mudancas curriculares ocorridas apos a implementacao das DCN vem ao encontro dessa pratica etica, politica e social da odontologia. Destaca-se tambem nos resultados pela revisao de literatura que, tanto os modos de entender saude como as praticas adotadas variam de individuo para individuo. E por fim a identificacao de um exemplo disponivel em publicacao, que foi realizado atraves do artigo: A historicidade filosofica do conceito de saude. Entende-se que contribuicoes convenientes das discussoes que ocorreram em torno das conferencias mundiais e regionais de promocao da saude que deram embasamento para o conceito de saude mais recentes, tiveram diversos prerequisitos fundamentais para a saude que tornaram evidente a integracao entre servico, ensino e antropologia a comunidade. E conclui-se com este trabalho que as questoes relativas a saude e a doenca, nao podem ser analisadas de forma isolada das demais dimensoes da vida social, medidas e permeadas pela cultura que confere sentido a essas experiencias, logo, faz-se necessaria a integracao servico, ensino, comunidade a antropologia.
Inverse pattern of photoreceptor abnormalities in retinitis pigmentosa and cone–rod dystrophy (2012)

The distribution patterns of the IS/OS line help to differentiate between RP and CRD.
Concatenated Trellis and Coordinate Interleaved Differential Space-Time Block Codes for OFDM (2007)

We propose a concatenated trellis code (TC) and coordinate interleaved differential space-time block code (STBC) for OFDM. The coordinate interleaver, provides signal space diversity and improves the codeword error rate (CER) performance of the system in wideband channels. Coordinate interleaved differential space-time block codes are proposed for the concatenated scheme. TC design criteria are derived, and the CER performances of the proposed system are compared with existing concatenated TC and differential STBC. The proposed scheme has superior diversity gain and improved CER performance compared to the existing differential schemes.
Alterations in the Pancreatic Resistance to Bile in the Pathogenesis of Acute Pancreatitis (1957)

ELLIOTT, DANIEL W. M.D.; WILLIAMS, ROGER D. M.D.; ZOLLINGER, ROBERT M. M.D. Author Information
Source-domain adaptive filtering for MIMO systems with application to acoustic echo cancellation (2010)

Combining the channels of a multiple input/multiple output (MIMO) system into suitably chosen modes by a domain transformation offers great improvements of adaptive filtering algorithms. In this paper we present an algorithm for adaptive MIMO filtering, called source-domain adaptive filtering (SDAF), with application to multichannel acoustic echo cancellation operating in an optimally adjusted transform domain without requiring a-priori knowledge about the system. Experimental results show a significant performance improvement compared to fixed transformation bases.
Targeting P-selectin blocks neuroblastoma growth (2017)

Selectins and their ligands have been implicated in tumor growth and progression in carcinomas, but their role in neuroblastoma has not been systematically examined. In the current study we evaluated L-, P- and E-selectin binding to neuroblastoma cells and the expression of some of their known ligands, namely CD44, CD24 and P-selectin glycoprotein ligand-1 (PSGL-1). Genetic loss of PSGL-1 or CD24 and pharmacological inhibition of P-selectin reduced P-selectin binding to neuroblastoma cells i<i>n vitro</i>. Targeting P-selectin using specific antibodies promoted a significant reduction in the growth of neuroblastoma tumors <i>in vivo</i>. In mechanistic studies binding of P-selectin to neuroblastoma cells activated Src and several other pro-survival kinases such as ERK1, AKT, FAK and p38. Interestingly, comparative mass single cell cytometry (CyTOF) analyses revealed considerable intra- and inter-cell line heterogeneity with respect to response to P-selectin binding. Additionally, the downstream response to all selectins showed general similarity. Our findings reported here not only provide pre-clinical evidence in support of therapeutic targeting of P-selectin, but also highlight the heterogeneity in response of tumor cells to P-selectin binding. These observations provide the basis for combining P-selectin inhibition with other targeted therapies for neuroblastoma.
New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1 (2021)

Tyrosyl-DNA phosphodiesterase 1 (TDP1) catalyzes the cleavage of the phosphodiester bond between the tyrosine residue of topoisomerase 1 (TOP1) and the 3' phosphate of DNA in the single-strand break generated by TOP1. TDP1 promotes the cleavage of the stable DNA-TOP1 complexes with the TOP1 inhibitor topotecan, which is a clinically used anticancer drug. This article reports the synthesis and study of usnic acid thioether and sulfoxide derivatives that efficiently suppress TDP1 activity, with IC<sub>50</sub> values in the 1.4-25.2 μM range. The structure of the heterocyclic substituent introduced into the dibenzofuran core affects the TDP1 inhibitory efficiency of the compounds. A five-membered heterocyclic fragment was shown to be most pharmacophoric among the others. Sulfoxide derivatives were less cytotoxic than their thioester analogs. We observed an uncompetitive type of inhibition for the four most effective inhibitors of TDP1. The anticancer effect of TOP1 inhibitors can be enhanced by the simultaneous inhibition of PARP1, TDP1, and TDP2. Some of the compounds inhibited not only TDP1 but also TDP2 and/or PARP1, but at significantly higher concentration ranges than TDP1. Leader compound <b>10a</b> showed promising synergy on HeLa cells in conjunction with the TOP1 inhibitor topotecan.
Experimental Toxoplasmosis in Japanese Quail (1994)

Twenty-four 5-month-old battery-hatched Japanese quail were inoculated orally with 10(5) (ME 49 strain, group A, 6 birds), 10(3) (ME 49 strain, group B, 6 birds), 10(5) (GT-1 strain, group C, 6 birds), and 10(3) (GT-1 strain, group D, 6 birds) Toxoplasma gondii oocysts. All birds in group C died or were euthanized within 8 days after inoculation (DAI). Five of the 6 birds in group D died or were euthanized 8, 9, 15, 19, and 23 DAI. One of the 6 quail in group A died 9 DAI, and 1 of the 6 birds in group D died 16 DAI. The 11 quail (1 from group D and 10 from groups A and B) were euthanized 63 DAI; T. gondii was isolated by bioassays in mice from the brains of 10, hearts of 10, and skeletal muscles of all 11 quail. Quail that survived marked small intestinal and splenic toxoplasmosis lived long enough to develop severe protozoal pneumonia, myocarditis, or meningoencephalitis. The quail that survived only to be examined at 63 DAI had moderate multifocal nonpurulent encephalitis and myositis and had a hypertrophic spleen that contained hemosiderin-laden macrophages. Toxoplasma gondii antibodies were found in the sera of all quail examined 63 DAI. Antibody titers to T. gondii in the modified agglutination test were higher than in the indirect hemagglutination and latex agglutination tests. Antibodies were not detected in quail sera examined by the Sabin-Feldman dye test.
Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling (2015)

Mutations in PARKIN (PARK2), an ubiquitin ligase, cause early onset Parkinson disease. Parkin was shown to bind, ubiquitinate, and target depolarized mitochondria for destruction by autophagy. This process, mitophagy, is considered crucial for maintaining mitochondrial integrity and suppressing Parkinsonism. Here, we report that under moderate mitochondrial stress, parkin does not translocate to mitochondria to induce mitophagy; rather, it stimulates mitochondrial connectivity. Mitochondrial stress-induced fusion requires PINK1 (PARK6), mitofusins, and parkin ubiquitin ligase activity. Upon exposure to mitochondrial toxins, parkin binds α-synuclein (PARK1), and in conjunction with the ubiquitin-conjugating enzyme Ubc13, stimulates K63-linked ubiquitination. Importantly, α-synuclein inactivation phenocopies parkin overexpression and suppresses stress-induced mitochondria fission, whereas Ubc13 inactivation abrogates parkin-dependent mitochondrial fusion. The convergence of parkin, PINK1, and α-synuclein on mitochondrial dynamics uncovers a common function of these PARK genes in the mitochondrial stress response and provides a potential physiological basis for the prevalence of α-synuclein pathology in Parkinson disease.
Complex Trait Genetics and Population Genetics in Psychiatry (2014)

Nearly all behavioral traits, ranging from personality traits such as neuroticism to schizophrenia and autism, are genetically influenced. With only minor exceptions, all are genetically complex—meaning that inheritance is not simply dominant or recessive or sex-linked, but follows more complex patterns indicative of more complex mechanisms. Most risk variants identified to date have only small effects on risk, and, in most cases, many risk variants at many risk loci interact with environmental factors to produce the phenotype. Such complexity has led to great challenges in increasing our knowledge of the inheritance of behavioral traits. Recent methodological advances have provided an improved set of tools that has led to advances in our understanding of the genetic influences on a range of behavioral traits. This chapter examines some of the issues involved that tend to make this a difficult problem and some of the solutions now being employed to approach those problems.
Downregulation of autophagy through CUL3-KLHL20-mediated turnover of the ULK1 and PIK3C3/VPS34 complexes (2016)

The molecular mechanism of macroautophagy/autophagy induction has been intensively studied, but little is known about downregulation of autophagy and how this process is restricted. In particular, how is autophagy maintained at an appropriate homeostatic level when cells are subjected to prolonged stress? In this study (see the related punctum in Autophagy 12-5), Liu et al. report a function of the CUL3-KLHL20 ubiquitin ligase in feedback regulation, leading to the downregulation of autophagy through the degradation of the ULK1 and PIK3C3/VPS34 complexes.
Volumetric Brain MRI Study in Fetuses with Congenital Heart Disease (2018)

Fetuses with congenital heart disease have smaller cerebellar volumes than healthy fetuses. Additional research is needed to assess this finding as a radiologic marker for long-term outcome.
A cDNA clone encoding a 10.8 kDa photosystem I polypeptide of barley (1988)

A cDNA clone encoding the barley photosystem I polypeptide which migrates with an apparent molecular mass of 16 kDa on SDS-polyacrylamide gels has been isolated. The 634 bp sequence of this clone has been determined and contains one large open reading frame coding for a 15,457 Da precursor polypeptide. The molecular mass of the mature polypeptide is 10,821 Da. The amino acid sequence of the transit peptide indicates that the polypeptide is routed towards the stroma side of the thylakoid membrane. The hydropathy plot of the polypeptide shows no membrane-spanning regions.
Tumour cell growth-inhibiting properties of water extract isolated from heated potato fi bre (Potex) (2009)

Commercially available potato fi bres are used as a food supplement which greatly improves the texture and stability of food. Food enriched with potato fi bre is often cooked, baked and roasted. Such treatment creates new compounds with potential new biological activities. The aim of the study was an in vitro evaluation of the anticancer activity of water extract obtained from heated potato fi bre (Potex). An antiproliferative eff ect of heated Potex extract is demonstrated in all tested tumour cell cultures, including rabdomyosarcoma-medulloblastoma (TE671), glioma (C6), breast (T47D), colon (HT-29) and lung (A549) carcinoma. The study also showed that the tested extract produced remarkable morphological changes in tumour cells, decreased cancer cell motility, and induced apoptotic cell death. What is essential is that the applied concentrations of heated Potex extract did not infl uence the viability of normal human skin fi broblasts (HSF), rat oligodendrocytes (OLN-93) and mouse neurons. The potential role of heated potato fi bre as a dietary chemopreventive is therefore suggested.
Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 5. Interactions of adenosine 5'-triphosphate derivatives with rat pyruvate kinases, Escherichia coli thymidine kinase, and yeast and rat hexokinases (1982)

Adenosine 5'-triphosphate (ATP) derivatives of the types N6-R-ATP [R = (CH2)nNHCOCH2I, (CH2)nNHCO-(CH2)mNHCOCH2I, or (CH2)nCON(Me)(CH2)mN(Me)CO(CH2)nNHCOCH2I], N6-Me-N6-R-ATP [R = (CH2)nN-(Me)CO(CH2)mNHCOCH2I], and 8-R-ATP [R = NM(CH2)nNHCOCH2I] with 5--19 spacer atoms between N6 or C-8 and iodine have been evaluated as potential exo-ATP-site-directed reagents for phosphokinases. Substrate and inhibitor properties indicated that the compounds possessed affinity for the ATP sites of the muscle (M), kidney (K), and liver (L) isozymes of rat pyruvate kinase (PK), of E. coli thymidine kinase (TK), and of yeast hexokinase (HK) and rat KH I, II, and III isozymes. Tests for time-dependent loss of enzyme activity (inactivation) were performed under conditions in which a large proportion of each phosphokinase was present as an enzyme-inhibitor complex. No ATP-site-directed inactivations resulted when the M, L, or K isozymes of PK were exposed for 8 h, 22 degrees C, to 5 mM levels of 18 ATP derivatives or 6 analogous ADP derivatives or when yeast HK or rat KH I, II, or III was exposed for 6 h, 22 degrees C, to 5 mM levels of 28 ATP derivatives. Escherichia coli TK was inactivated by 6 of 25 ATP derivatives tested at 10 mM, 6 h, 0 degrees C; inactivation was slowed by MgATP in the case of N6-CH3-N6-R-ATP [R = (CH2)4N(CH3)CO(CH2)5NHCOCH2I]. Only 1% of 298 enzyme-inhibitor combinations exhibited ATP-site-directed inactivation, signifying that few suitably positioned and sufficiently reactive nucleophilic groups were present near the enzymic ATP sites. Studies have now shown that exo-active-site-directed reagents can act as isozyme- or species-selective enzyme inhibitors. The present survey indicates that in many cases such reagents may be difficult of access when data are not available regarding structural or physicochemical features of the target enzyme adjacent to its catalytic site.
Cooperative compressed spectrum sensing model for regional radio monitoring (2014)

Detection and direction finding of illegal emission source is the core issue of radio monitoring network. However, the performances of traditional fixed stations and mobile stations which are based on energy detection and work individually are often compromised with multipath fading and shadowing in urban environment. To mitigate the impact of these issues, a cooperative compressed spectrum sensing model which consists of several sensing nodes and a fusion node is proposed in this paper. The maximum-minimum eigenvalue based detection method is applied to the sensing model. Simulation results show that cooperative compressed sensing provides an efficient way to sense radio signal which is sparse at frequency domain.
Cephalexin compared with ampicillin in urinary tract infections in children (1975)

The efficacy of cephalexin compared to that of ampicillin has been studied in 92 children with urinary tract infections (UTI). In 26 patients more than one UTI was treated, the total number of infections treated being 118, 59 with cephalexin and 59 with ampicillin After cephalexin treatment 49 cases (84.5%) gave pathogen-free urinary samples compared to 37 cases (62.7% after ampicillin. Eseherichia coil was absent in the post-treatment urine samples of 33 patients out of 36 (91.6%) treated with cepha lexin and in 22 out of 40 patients (55.0%) treated with ampicillin. No side-effects to cephalexin were reported compared to an incidence of 15% in patients receiving ampicillin
A case for micro-cellstores (2011)

Increased energy costs and concerns for sustainability make the following question more relevant than ever: can we turn old or unused computing equipment into cost- and energy-efficient modules that can be readily repurposed? We believe the answer is yes, and our proposal is to turn unused smartphones into micro-data center composable modules. In this paper, we introduce the concept of a Micro-Cellstore (MCS), a stand-alone data-appliance housing dozens of recycled smartphones. Through detailed power and performance measurements on a Linux-based current-generation smartphone, we assess the potential of MCSs as a data management platform. In this paper we focus on scan-based partitionable workloads. We show that smartphones are overall more energy efficient than recently proposed low-power alternatives, based on an initial evaluation over a wide range of single-node database scan workloads, and that the gains become more significant when operating on narrow tuples (i.e., column-stores, or compressed row-stores). Our initial results are very encouraging, showing efficiency gains of up to 6×, and indicate several promising future directions.