gebhart/patrepeval huggingface dataset:
Glaucoma and Alzheimer: Neurodegenerative disorders show an adrenergic dysbalance (2022)

Glaucoma disease is characterized by an increased intraocular pressure (IOP), glaucomatous alterations of the optic disc and corresponding visual field defects. Even lowering the main risk factor IOP until an individual target level does not prevent this neurodegenerative disorder from proceeding. Several autoimmune mechanisms were discovered, partly showing a functionality. One of these autoimmune phenomena targets the ß2-adrenergic receptor (ß2-AR; i.e. agonistic autoantibodies; ß2-agAAb) and is linked to an elevated IOP and an impaired retinal microcirculation. As neurodegenerative disorder, Alzheimer's Disease (AD) is postulated to share a common molecular mechanism with glaucoma. In the present study we investigated autoimmune phenomena targeting the ß2-AR in patients with AD. Sera of the patients were analyzed in a rat cardiomyocyte bioassay for the presence of functional autoantibodies against ß2-AR. In addition, different species of amyloid beta (Aß) monomers were tested (Aß1-14, Aß10-25, Aβ10-37 Aß1-40, Aß1-42, Aβ28-40, and Aß-[Pyr]3-43). Our results demonstrate that none of the short-chain Aß (Aß1-14, Aß10-25, or Aβ28-40) showed any agonistic or inhibitory effect on ß2-AR. Contrary, long-chain Aß-[Pyr]3-43, representing a major neurogenic plaque component, exerted an activation that after blocking by the ß2-AR antagonist ICI118.551, could be identified as that the effect was realized via the ß2-AR. Moreover, the long chain Aß1-40, Aβ1-42, and Aβ10-37, yet not the short-chain Aß peptides prevented the clenbuterol induced desensitization of the ß2-AR. In addition, we identified functional autoantibodies in the sera of AD patients, activating the ß2-AR, like the ß2-agAAb found in patients with glaucoma. As autoimmune mechanisms were reportedly involved in the pathogenesis of glaucoma and Alzheimer's Disease, we postulate that overstimulation of the ß2-AR pathway can induce an adrenergic overdrive, that may play an important role in the multifactorial interplay of neurodegenerative disorders.
Role of Exogenous Oxytocin in Eliciting Milk Ejection in Dairy Cows (1980)

The efficacy of small doses of exogenous oxytocin in eliciting milk ejection was measured in eight lactating Holstein cows. Treatments comprised intravenous administration of .02, .05, .10, and .30 IU of oxytocin. The smallest dose of oxytocin that induced milk ejection in all cows was .10 IU. Administration of .10 and .30 IU produced greater peak rates of milk flow and shorter milking times. Ranges for these two variables were 2.9 to 3.9 kg/min and 4.8 to 5.6 min. Variations in mild yield (8.2 to 9.1 kg/milking) were not significant, but more fat was harvested after administration of the two higher doses. Differences in peak concentrations of serum oxytocin were 17.7 to 21.2 microunits/ml. Differences in latent time before peak concentration was reached were 1.3 to 4.0 min.
Minimizing the Number of Switchings in an SS/TDMA System (1985)

In this paper, we investigate the problem of constructing a TDMA frame for a multibeam satellite system. Our objective is to permit the transmission of a given pattern of traffic, while ensuring that the number of times that the on-board switch needs to be reconfigured is minimized. We find that the underlying optimization problem is computationally intractable, but go on to suggest an efficient heuristic algorithm which we validate through experiments on randomly generated traffic patterns.
Dealing with the Reality of Autism: A Psychoeducational Program in Milan, Italy (2000)

(2000). Dealing with the Reality of Autism: A Psychoeducational Program in Milan, Italy. International Journal of Mental Health: Vol. 29, International Priorities for Developing Autism Services Via the TEACCH Model—1, pp. 50-71.
An improper treatment of quantification in ordinary English (1983)

In most democratic countries most politicians can fool most of the people on almost every issue most of the time.
Low density polyethylene-polypropylene blends: Part 2 - Strengthening and toughening with copolymer (2003)

The strengthening and toughening of low density polyethylene (LDPE)polypropylene (PP) blends with a commercial ethylene/propylene block copolymer (CO) have been investigated. It is shown that the addition of the copolymer improved the ductility of the LDPE-PP blends without any loss of elastic modulus. Particularly for the PP rich LDPE-PP blends, the copolymer can improve the ductility, tensile strength and impact strength simultaneously. It was found that the copolymer has no obvious influence on the crystallisation behaviour of the LDPE and PP phases, whereas the interfacial adhesion was enhanced significantly. The results suggested that the ethylene/propylene block copolymer is a suitable compatibiliser for LDPE-PP blends, which can be used as an effective additive for the recycling of the polyalkene mixtures, especially the PP rich LDPE-PP mixtures. (C) 2003 IoM Communications Ltd.
What Are the Characteristics of Obese Adults without Metabolic Complications (2011)

an university hospital. We analyzed self-reported questionnaires, records of physical examinations, laboratory tests, and body composition data from computed tomography. Elevated fasting glucose, hypertension, hypertriglyceridemia, and low HDL-cholesterol were evaluated as metabolic complications. Results: Those who were obese but had no metabolic complications were 16/75 (21.3%) in men and 80/216 (37.0%) in women. After adjusting for age, daily oral intake (kcal), body mass index, smoking status, habit of exercise, family history of metabolic diseases, habit of alcohol drinking, and menopause for women, body mass index (odds ratio [OR], 0.81; 95% confidence interval [CI], 0.71 to 0.92) and HOMA-IR index (OR, 0.39; 95% CI, 0.20 to 0.76) were significant factor for obesity without metabolic complications in women. Homeostasis model assessment for insulin resistance (HOMA-IR) index was marginally significant in men (OR, 0.20; 95% CI, 0.04 to 1.04). Conclusion: Lower insulin resistance and lower body mass index were associated with obesity without metabolic diseases among obese women.
ChemInform Abstract: Synthesis and NMR Characterization of P‐Vinyl Substituted Phosphazene Precursors. (1989)

Abstract Lithiation of the bissilylamine (I) followed by addition of chlorophosphines such as (II) and vinylmagnesium bromide (III) yields silylamino phosphines such as (IV).
PLSCR1 amplifies anaphylactic reaction through increased mast cell degranulation. (2017)

&lt;p&gt;A passive systemic anaphylaxis (PSA) was carried out on wild-type (WT) and &lt;i&gt;Plscr1&lt;/i&gt;&lt;sup&gt;&lt;i&gt;-/-&lt;/i&gt;&lt;/sup&gt; (KO) mice. (A) PSA was monitored by following the drop in body temperature every five minutes after antigen injection (t = 0) using a thermal probe reader. Data are presented as mean ± s.e.m. with 5 mice (3 experiments). Two-way ANOVA followed by Sidak’s multiple comparisons test was used to compare the two groups. *: P &lt; 0.05; ****: P &lt; 0.0001. (B) PSA was monitored by measurement of the histamine released in the serum 25 minutes after antigen injection in the two groups of mice. Histamine was assayed using an EIA kit. The values obtained for each individual mouse are shown. Data are presented as mean ± s.e.m. Statistical analysis: unpaired Student &lt;i&gt;t&lt;/i&gt; test. **: P &lt;0.01.&lt;/p&gt;
Survivorship of the Charnley Total Hip Arthrplasty in Juvenille Chronic Arthritis: A Follow-Up of 186 Cases for 22 Years (1997)

Between 1971 and 1991 we performed Charnley low-friction arthroplasty (LFA) on 116 patients (186 hips) with juvenile chronic arthritis (JCA). We have now carried out a survival study, taking endpoints as revision, death or the end of the year 1993. Overall survival was 91.9% at ten years and 83.0% at 15 years. That of the femoral component was 95.6% at ten years and 91.9% at 15 years and of the acetabulum 95.0% and 87.8%, respectively. Only the use of steroids significantly impaired the survival. We therefore recommend the use of Charnley LFA for young patients with JCA requiring total hip replacement.
Impact of double Rayleigh scattering noise in time division multiplexed Raman pumping schemes (2004)

The impact of double-Rayleigh scattering noise in time-division-multiplexed counter-propagating Raman pumping schemes is theoretically and experimentally investigated. High pump modulation frequencies effectively reduce DRS noise enhancement which is induced, especially at low duty-cycles, by TDM-pumping.
Software Synthesis for Hard Real-Time Embedded Systems with Energy Constraints (2008)

Over the last years, the issue of reducing energy consumption in hard real-time embedded systems has received considerable attention from the scientific community, since responsiveness and low energy consumption are often conflicting requirements. In this context, several techniques have been proposed, mostly, adopting DVS (dynamic voltage scaling) for reducing energy consumption in conjunction with runtime scheduling policies for dealing with stringent timing constraints. Nevertheless, those approaches generally disregard inter-task relations and runtime overheads (e.g. voltage switching) as well as adopt specialized operating systems. This paper presents a software synthesis method for hard real-time systems with energy constraints, taking into account DVS, inter-task relations and runtime overheads. The proposed method adopts a formal model based on time Petri nets in order to provide a basis for precise pre-runtime schedule generation.
Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth (2010)

Activation of the orphan nuclear receptor TR3/Nur77 (NR4A1) promotes apoptosis and inhibits pancreatic tumor growth, but its endogenous function and the effects of its inactivation have yet to be determined. TR3 was overexpressed in human pancreatic tumors compared with nontumor tissue. Small interfering RNA-mediated knockdown of TR3 or cell treatment with the TR3 antagonist 1,1-bis(3'-indolyl)-1-(p-hydroxyphenyl)methane (DIM-C-pPhOH) decreased proliferation, induced apoptosis, and decreased expression of antiapoptotic genes including Bcl-2 and survivin in pancreatic cancer cells. Survivin suppression was mediated by formation of a TR3-Sp1-p300 DNA binding complex on the proximal GC-rich region of the survivin promoter. When administered in vivo, DIM-C-pPhOH induced apoptosis and inhibited tumor growth in an orthotopic model of pancreatic cancer, associated with inhibition of the same antiapoptotic markers observed in vitro. Our results offer preclinical validation of TR3 as a drug target for pancreatic cancer chemotherapy, based on the ability of TR3 inhibitors to block the growth of pancreatic tumors.
Epitaxial TiO2/SnO2 core–shell heterostructure by atomic layer deposition (2012)

Taking TiO2/SnO2 core–shell nanowires (NWs) as a model system, we systematically investigate the structure and the morphological evolution of this heterostructure synthesized by atomic layer deposition/epitaxy (ALD/ALE). All characterizations, by X-ray diffraction, high-resolution transmission electron microscopy, selected area electron diffraction and Raman spectra, reveal that single crystalline rutile TiO2 shells can be epitaxially grown on SnO2 NWs with an atomically sharp interface at low temperature (250 °C). The growth behavior of the TiO2 shells highly depends on the surface orientations and the geometrical shape of the core SnO2 NW cross-section. Atomically smooth surfaces are found for growth on the {110} surface. Rough surfaces develop on {100} surfaces due to (100) − (1 × 3) reconstruction, by introducing steps in the [010] direction as a continuation of {110} facets. Lattice mismatch induces superlattice structures in the TiO2 shell and misfit dislocations along the interface. Conformal epitaxial growth has been observed for SnO2 NW cores with an octagonal cross-section ({100} and {110} surfaces). However, for a rectangular core ({10} and {010} surfaces), the shell also derives an octagonal shape from the epitaxial growth, which was explained by a proposed model based on ALD kinetics. The surface steps and defects induced by the lattice mismatch likely lead to improved photoluminescence (PL) performance for the yellow emission. Compared to the pure SnO2 NWs, the PL spectrum of the core–shell nanostructures exhibits a stronger emission peak, which suggests potential applications in optoelectronics.
Intelligent Omni-Surfaces (IOSs) for the MIMO Broadcast Channel (2022)

In this paper, we consider intelligent omni-surfaces (IOSs), which are capable of simultaneously reflecting and refracting electromagnetic waves. We focus our attention on the multiple-input multiple-output (MIMO) broadcast channel, and we introduce an algorithm for jointly optimizing the covariance matrix at the base station, the matrix of reflection and transmission coefficients at the IOS, and the amount of power that is reflected and refracted from the IOS. The distinguishable feature of this work lies in taking into account that the reflection and transmission coefficients of an IOS are tightly coupled. Simulation results are illustrated to show the convergence of the proposed algorithm and the benefits of using surfaces with simultaneous reflection and refraction capabilities.
Azimuthal polarization for Raman enhancement in capillary waveguides (2013)

Hollow, metal-lined capillary waveguides have recently been utilized in spontaneous gas-Raman spectroscopy to improve signal strength and response time. The hollow waveguide is used to contain the sample gases, efficiently propagate a pump beam, and efficiently collect Raman scattering from those gases. Transmission losses in the waveguide may be reduced by using an azimuthally polarized pump beam instead of a linearly or radially polarized pump. This will lead to improved Raman signal strength, accuracy, and response time in waveguide-based Raman gas-composition sensors. A linearly polarized laser beam is azimuthally polarized using passive components including a spiral phase plate and an azimuthal-type linear analyzer element. Half-wave plates are then used to switch between the azimuthally polarized beam and the radially polarized beam with no change in input pump power. The collected Raman signal strength and laser-throughput are improved when the azimuthally polarized pump is used. Optimization of the hollow waveguide Raman gas sensor is discussed with respect to incident pump polarization.
LTCC Embedding of SiC Power Devices for High Temperature Applications over 400 °C (2020)

This paper encompasses a novel packaging concept based on the embedding of semiconductor devices in Low Temperature Cofired Ceramic (LTCC) multilayer substrates. The wide-bandgap power semiconductor made out of silicon carbide (SiC) is embedded within the co-firing process of the LTCC at around 750 to 850 °C. Filled vias and inlays, realized in the same process, form the electrical interconnection and heat dissipation. This approach combines high-temperature stability over 400 °C junction temperature, compactness, and 3D integration ability into one concept to fulfill all advantages of SiC power semiconductors and other future wide bandgap devices. Moreover, the package design aims for hermetical sealing and harsh environment applications. Various geometric concepts for LTCC pre-packages are developed to investigate the thermal behavior. Two of the ideas could improve the thermal resistance up to 45 % compared to the state of the art power modules. Afterward, complete power modules were designed. In the end, electrical simulations have been executed to analyze the parasitic inductances and the different concepts are discussed.
Compact dictionaries for fault diagnosis in scan-BIST (2004)

We present a new technique for generating compact dictionaries for cause-effect fault diagnosis in scan-BIST. This approach relies on the use of three compact dictionaries: 1) D/sub 1/, containing compacted LFSR signatures for a small number of patterns and faults with high detection probability, 2) an interval-based pass/fail dictionary D/sub 2/ for the BIST patterns and for faults with relatively lower detection probability, and 3) D/sub 3/ containing compacted LFSR signatures for clean up ATPG vectors and random-resistant faults. We show that D/sub 2/, which is two orders of magnitude smaller than a maximal-resolution pass/fail dictionary, provides nearly the same diagnostic resolution as an uncompacted dictionary. We also show that, by using a 16-bit LFSR signature for D/sub 1/ and D/sub 3/, we obtain two to three orders of magnitude reduction in dictionary size, yet nearly no loss in diagnostic resolution. Together, these three compact dictionaries provide an. efficient solution to the problem of cause-effect diagnosis in scan-based BIST. These dictionaries can also be used to target unmodeled faults using scoring algorithms.
The 3rd dimension of CHI (3DCHI): touching and designing 3D user interfaces (2012)

In recent years 3D has gained increasing amount of attention - interactive visualization of 3D data has become increasingly important and widespread due to the requirements of several application areas, and entertainment industry has brought 3D experience to the reach of wide audiences through games, 3D movies and stereoscopic displays. However, current user interfaces (UIs) often lack adequate support for 3D interactions: 2D metaphors still dominate in GUI design, 2D desktop systems are often limited in cases where natural interaction with 3D content is required, and sophisticated 3D user interfaces consisting of stereoscopic projections and tracked input devices are rarely adopted by ordinary users. In the future, novel interaction design solutions are needed to better support the natural interaction and utilize the special features of 3D technologies. In this workshop we address the research and industrial challenges involved in exploring the space where the flat digital world of surface computing meets the physical, spatially complex, 3D space in which we live. The workshop will provide a common forum for researchers to share their visions of the future and recent results in the area of improving 3D interaction and UI design.
Nanometer-scale scanning sensors fabricated using stencil lithography (2003)

We describe a flexible technique for fabricating 10-nm-scale devices for use as high-resolution scanning sensors and functional probes. Metallic structures are deposited directly onto atomic force microscope tips by evaporation through nanoscale holes fabricated in a stencil mask. We report on the lithographic capabilities of the technique and discuss progress in one initial application, to make high-spatial-resolution magnetic force sensors.
Generating significant subassemblies from 3D assembly models for design reuse (2018)

Significant subassemblies are defined as the reusable regions of pre-existing 3D assembly models. A significant subassembly has great significances for design reuse as it aggregates abundant knowledge in a vivid 3D CAD model and enables designers to reuse existing mature designs from a high-level perspective. Consequently, this paper contributes to significant subassembly generation from pre-existing 3D assembly models for design reuse. The paper first gives an explicit definition of significant subassemblies and further explores the multilevel knowledge embedded in these significant subassemblies. Based on the above definition and multilevel knowledge, a knowledge-based approach is then proposed for significant subassembly generation, which includes three phases: (1) identifying candidate subassemblies with high cohesion inside and low coupling outside using the Markov clustering process; (2) removing normal candidate subassemblies with low reusability and less information, and generating filtered subassemblies using the proposed assembly frequency – inverse mean subassembly frequency based scheme; and (3) determining significant subassemblies by measuring the complexity of the filtered subassemblies. Finally, a computer numerical control honing machine model is taken as an application example to demonstrate the effectiveness of the proposed approach.
Metamorphism and Anatexis in the Mafic Complex Contact Aureole, Ivrea Zone, Northern Italy (2000)

Emplacement of mantle-derived magma (magmatic accretion) is the total thermal budget of the continental lower crust, often presumed or inferred to be an important cause of regional produce regional granulite facies metamorphism, and granulite facies metamorphism and crustal anatexis. The juxgenerate Y-and heavy rare earth element (HREE)taposition of mafic cumulates and regionally distributed granulite depleted granitoids (Ellis, 1987). Accretion of mafic facies rocks has led some to consider the Ivrea zone (northern Italy, magma and migration of partial melt will internally Southern Alps) as an important exposure that demonstrates this stratify, chemically differentiate, and deplete the concausal relationship. However, regional PTt paths indicated by tinental lower crust in large ion lithophile elements metamorphic reaction textures and PT conditions inferred from (LILE). Magmatic accretion has been invoked to provide geothermobarometry indicate that the emplacement of mafic plutonic the heat and mass necessary for sustained magmatism in rocks (Mafic Complex) at the Ivrea zone occurred during detectonic settings such as Phanerozoic extensional terranes compression from ambient pressures at the regional thermal maximum. (
P300 in Clinical Applications: Meaning, Method, and Measurement (1991)

.The P300 (P3) event-related brain potential (ERP) is sensitive to the cognitive changes resulting from normal aging and the mental decline associated with dementia and other cognitive disorders. The relationship between the P3 ERP and the cognitive dysfunction found in dementing illness is reviewed to provide context for discussion of the theoretical meaning, appropriate methods, and measurement of the P3 component in clinical populations. The utility of the P3 with respect to extraneous factors that can contribute to its normal variability also is examined. It is concluded that the P3 ERP can provide useful information about cognitive function in a clinical setting, but that task and biological factors must be considered in order to obtain more precise and interpretable results.
Trapped Entanglements vs. Dissociable Junctions in Networks Cross-Linked in Strained States (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTrapped Entanglements vs. Dissociable Junctions in Networks Cross-Linked in Strained StatesHsin-Chia Kan and John D. FerryCite this: Macromolecules 1980, 13, 5, 1313–1314Publication Date (Print):September 1, 1980Publication History Published online1 May 2002Published inissue 1 September 1980https://pubs.acs.org/doi/10.1021/ma60077a054https://doi.org/10.1021/ma60077a054research-articleACS PublicationsRequest reuse permissionsArticle Views31Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts