gebhart/patrepeval huggingface dataset:
Searching in metric spaces (2001)

The problem of searching the elements of a set that are close to a given query element under some similarity criterion has a vast number of applications in many branches of computer science, from pattern recognition to textual and multimedia information retrieval. We are interested in the rather general case where the similarity criterion defines a metric space, instead of the more restricted case of a vector space. Many solutions have been proposed in different areas, in many cases without cross-knowledge. Because of this, the same ideas have been reconceived several times, and very different presentations have been given for the same approaches. We present some basic results that explain the intrinsic difficulty of the search problem. This includes a quantitative definition of the elusive concept of "intrinsic dimensionality." We also present a unified view of all the known proposals to organize metric spaces, so as to be able to understand them under a common framework. Most approaches turn out to be variations on a few different concepts. We organize those works in a taxonomy that allows us to devise new algorithms from combinations of concepts not noticed before because of the lack of communication between different communities. We present experiments validating our results and comparing the existing approaches. We finish with recommendations for practitioners and open questions for future development.
Nouvelle technologie GISA pour la conception de filtre passe-bande à pont inductif à hautes performances dans le domaine millimétrique (2015)

National audience
Abstract 4800: Identification of candidate predisposition genes for familial uterine leiomyomas (2015)

Abstract Uterine leiomyomas are benign smooth muscle tumors that cause considerable morbidity. They are among the most common human tumors and are the leading indication for hysterectomy. Genetic factors play an important role in the development of these hormone-dependent tumors. First-degree relatives of uterine leiomyoma patients are at increased risk for developing leiomyomas. Twin studies have shown that an inherited predisposition is likely to contribute to the formation of these lesions. Furthermore, the clinical and molecular features of familial leiomyomas differ from those of sporadic cases. Thus far, the only known high risk predisposition defect is dominantly inherited loss of function mutations in fumarate hydratase (FH) that underlie a tumor predisposition syndrome hereditary leiomyomatosis and renal cell cancer (HLRCC). The aim of this study is to identify novel candidate high risk susceptibility genes for uterine leiomyomas. The study material consists of five FH mutation-negative families, which have at least four individuals diagnosed with uterine leiomyomas, originating from Northern Finland. Genomic DNA extracted from peripheral blood lymphocytes from one affected individual from each family has been exome sequenced. Exome sequencing data have been analyzed for rare non-synonymous variants with allele frequencies less than 0.1% in 4 019 controls. All protein-truncating variants as well as missense and splice site variants affecting the same gene in at least two individuals that are predicted to be protein-damaging have been included for further analysis. Preliminarily 25 candidate susceptibility genes have been shortlisted. Relevant variant calls will be verified by direct sequencing, followed by segregation analysis and assessment of loss of heterozygosity in the corresponding tumor samples. Identification of novel genes predisposing to familial uterine leiomyomas may provide a better understanding into the tumorigenic mechanisms and could lead to new prevention approaches and personalized medical treatments in the future. Citation Format: Hanna-Riikka Heinonen, Outi Uimari, Jaana Tolvanen, Markku Ryynänen, Lauri A. Aaltonen, Pia Vahteristo. Identification of candidate predisposition genes for familial uterine leiomyomas. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4800. doi:10.1158/1538-7445.AM2015-4800
Application of CAN in vehicle traction control system (2006)

In this paper, CAN bus, which works in good real-time and high reliability, was designed and applied to meet the need of real-time control for traction control system (TCS) of 2WD vehicle. TCS controllers were developed which include two electrical control units (ECU): one is the host ECU which receives the signals from sensors such as the wheel speed sensors, longitudinal acceleration sensor, accelerator pedal position sensor, and engine throttle position sensor, and sends the control commands to the actuators according to the control algorithm. The other is the throttle controller which receives the throttle control command from host ECU by CAN bus to run the engine throttle actuator by which engine output torque can be reduced to avoid the excessive spin of the driving wheels. Meanwhile throttle controller feedbacks the running states of the actuator to the host ECU by CAN bus. In addition, the host ECU controls the hydraulic control unit (HCU) to regulate brake torque of driving wheels to control wheel slip. To verify the reliability of TCS controllers and the accuracy of data transmission over CAN bus, the hardware-in-the-loop (HIL) tests were performed by means of the vehicle rapid development system (RDS). Test results show that not only CAN communication is reliable and accurate, but also TCS controllers can effectively keep the slip rate of the driving wheels in the optimum range and improve the driving ability of the vehicle.
利用動態散射光研究磺酸鈉聚苯乙烯(NaPSS)的濃度和分子量其微流變性質的影響 (2010)

Microrheology has proven to be a very useful technique for the determination of the viscoelastic properties of biological samples such as living cells, bio-fluids, and polymer solutions due to the following unique features: (1) require only extremely small amount of sample (~ micro-liter); (2) capable of probing local viscoelastic properties of an heterogeneous medium with micron scale spatial resolution; (3) capable of monitoring the temporal change of the sample viscoelastic properties; (4) fairly high sensitivity. Microrheology can be accomplished by different methods such as active vs. passive, single vs. multiple particle tracking, and with vs. without optical trapping. in this paper, we report our study of the viscoelastic properties of sodium polystyrene sulfonate (NaPSS) solution with different concentration (in the range of 10^(-4)M to 10^(-3)M) and with different molecular weight (70KDa vs. 200KDa) via (multiple-particle) dynamic light scattering (DLS) method. The viscoelastic properties of the sample solutions are characterized in terms of the dynamic complex shear modulus G(superscript *) (consisting of the storage modulus G' and the loss modulus G”) as a function of frequency (f); in addition, the effect of polymer concentration and molecular weight on G' and G”, and on the relaxation time are presented.
Corrigendum: Electronic Transitions in Conformationally Controlled Tetrasilanes with a Wide Range of SiSiSiSi Dihedral Angles (2015)

The authors noticed that in their Full Paper one of the units in Table 1 has been labeled incorrectly. In Table 1, the heading for the fifth column states that the units of B are 102 βe/cm−1. This is wrong, the units are 104 Debye2βe/cm−1. This mistake has no effect anywhere in the rest of the manuscript. The authors apologize for the oversight, and would like to thanks Professors Raul Crespo and Carmen Piqueras of the University of Valencia, Spain, for bringing the error to their attention.
High quality In0.53Ga0.47As Schottky diode formed by graded superlattice of In0.53Ga0.47As/In0.52Al0.48As (1989)

A high quality In0.53Ga0.47As Schottky barrier diode fabricated by using a thin graded superlattice (SL) of In0.53Ga0.47As/In0.52Al0.48As grown by molecular beam epitaxy is reported for the first time in this letter. The effective Schottky barrier heights of ∼0.71 and ∼0.60 eV were obtained for the Au- and Cr-Schottky contacts, respectively. Excellent current-voltage and capacitance-voltage characteristics were obtained for these diodes. The graded InGaAs/InAlAs SL structure allows one to circumvent the problem of carrier pileup associated with abrupt heterostructures, and hence is advantageous for forming Schottky contacts on InGaAs for high-speed optoelectronic device applications.
Gravimetry and Gravity Field Models (1991)

A compendium of four years' work in the measurement and modeling of the Earth's gravity field shows steady progress in the improvement of spherical harmonic expansions and includes continued analysis of a yet‐to‐be realized dedicated space gravity mission. Newton's gravitational law was put to the test, the airborne gravity gradiometer was field tested, and airborne gravimetry is achieving respectable results. The review covers work performed at U.S. institutions and published during the quadrennium 1987–1990.
Bit-synchronous polarisation and phase modulationscheme for improving theperformance of optical amplifier transmission systems (1996)

Scrambling the state-of-polarisation of the optical carrier at the bit rate of the transmitted signal can greatly improve the transmission performance of long-haul optical amplified transmission systems. By superimposing optical phase modulation onto the synchronous polarisation scrambling we can improve the performance of both single channel and WDM transmission systems even further. The authors successfully applied this technique of synchronous polarisation/phase modulation to transmit 100 Gbit/s (20 5 Gbit/s WDM channels) over 6300 km.
A randomized, double‐blind, placebo controlled, multi‐center study of intravenous iron sucrose and placebo in the treatment of restless legs syndrome (2009)

Iron deficiency may exacerbate symptoms in the Restless Legs Syndrome (RLS). We investigated the effect of intravenous iron sucrose or placebo on symptoms in patients with RLS and mild to moderate iron deficit. Sixty patients with primary RLS (seven males, age 46 (9) years, S-ferritin < or =45 microg/L) recruited from a cohort of 231 patients were randomly assigned in a 12-months double-blind, multi-centre study of iron sucrose 1000 mg (n = 29) or saline (n = 31). The primary efficacy variable was the RLS severity scale (IRLS) score at week 11. Median IRLS score decreased from 24 to 7 (week 11) after iron sucrose and from 26 to 17 after placebo (P = 0.123, N.S. for between treatment comparison). The corresponding scores at week 7 were 12 and 20 in the two groups (P = 0.017). Drop out rate because of lack of efficacy at 12 months was 19/31 after placebo and 5/29 patients after iron sucrose (Kaplan-Meier estimate, log rank test P = 0.0006) suggesting an iron induced superior long term RLS symptom control. Iron sucrose was well tolerated. This study showed a lack of superiority of iron sucrose at 11 weeks but found evidence that iron sucrose reduced RLS symptoms both in the acute phase (7 weeks) and during long-term follow up in patients with variable degree of iron deficiency. Further studies on target patient groups, dosing and dosing intervals are warranted before iron sucrose could be considered for treatment of iron deficient patients with RLS.
Non-operative treatment of meniscal tears. (1989)

In a retrospective review of the results of 3,612 arthroscopic procedures that were performed for the treatment of an acute or a chronic meniscal lesion, with or without an associated ligamentous lesion, we identified eighty meniscal tears (in seventy-five patients) that had been assumed to be stable. Seventy were vertical longitudinal tears and ten were vertical radial tears. The seventy longitudinal tears included fifty-two lateral and eighteen medial meniscal lesions. All of the radial tears were in the lateral meniscus. Of the seventy-five patients, fifty-two had been followed for two to ten years. At the time of follow-up, only six of these fifty-two patients had needed additional intervention because of symptoms that were related to the meniscal tear. Four of them had the intervention after a sports-related traumatic extension of a stable tear, and two, because persistent symptoms were caused by the original meniscal lesion. A repeat arthroscopy was performed on thirty-two patients (twenty-six of whom had a longitudinal tear and six of whom had a radial tear), at an average of twenty-six months after the original arthroscopy. Seventeen of the twenty-six longitudinal tears had completely healed. Five of the six radial tears had no evidence of healing and one had extended. Neither ligamentous laxity nor a meniscal tear that was chronic at the time when it was discovered appeared to preclude healing of the stable longitudinal tears. No localized degenerative changes in the adjacent articular cartilage were found in association with any of the stable vertical longitudinal or radial meniscal lesions. Excluding the six patients who had had additional surgical treatment, none of the fifty-two patients who filled out a questionnaire reported that they had symptoms of a meniscal lesion, and none of the forty-two patients who were re-examined two years or more after the operation had signs of a meniscal lesion. Stable vertical longitudinal tears, which tend to occur in the peripheral vascular portions of the menisci, have great potential for healing. The tear should be left alone unless it is the only abnormality that is found and it is causing symptoms that warrant treatment. Stable radial tears, which tend to occur in the avascular inner one-third of the meniscus, have little potential for healing. Whether it is best to leave these lesions alone or to fashion an intact rim by contouring the meniscus was not established by this study.
Trace Spectral Analysis toward Dynamic Levels of Detail (2011)

The emergence of Petascale systems has raised new challenges to performance analysis tools. Understanding every single detail of an execution is important to bridge the gap between the theoretical peak and the actual performance achieved. Tracing tools are the best option when it comes to providing detailed information about the application behavior, but not without liabilities. The amount of information that a single execution can generate grows so fast that it easily becomes unmanageable. An effective analysis in such scenarios necessitates the intelligent selection of information. In this paper we present an on-line performance tool based on spectral analysis of signals that automatically identifies the different computing phases of the application as it runs, selects a few representative periods and decides the granularity of the information gathered for these regions. As a result, the execution is completely characterized at different levels of detail, reducing the amount of data collected while maximizing the amount of useful information presented for the analysis.
Thickness and substrate dependence of THz modulation efficiency in organic/inorganic semiconductor structures (2011)

We report on the thickness dependence of THz modulation efficiency in an organic phthalocyanine (CuPc) film on a Si wafer. The modulation efficiency is also associated with the inorganic semiconductor substrate. This finding confirms that the THz modulation is caused by the injected carriers, excited by optical excitation, into the CuPc film.
A Look at Ear Canal Changes with Jaw (1992)

Two procedures were used with one subject to examine changes in the ear canal with jaw motion. Silicone ear impressions were examined to measure the effect of jaw position. Magnetic resonance imaging was used to define the three-dimensional structure of the canal and visualize key underlying tissue. Results showed that inexpensive impressions can detail changes in the cartilaginous region of the canal. Approximately a 25% change in this subject's ear canal with different jaw positions was observed in the anterior/posterior plane with essentially no change in the superior/inferior plane. This is likely related to asymmetric stress from action of the mandibular condyle on neighboring cartilaginous tissue. Solutions to jaw motion-induced feedback problems are suggested.
Tumor infiltrating lymphocytes (TILs) indicate trastuzumab benefit in early-stage HER2-positive breast cancer (HER2+ BC) (2013)

Oral Presentation - Abstract S1-05
The allele interaction between apolipoprotein ɛ2 and ɛ4 in Taiwanese Alzheimer's disease patients (2004)

The low allele frequency of epsilon4 in persons with an epsilon2 allele suggests that this may be part of the protective effect of epsilon2 against AD.
Phage display of ScFv peptides recognizing the thymidine(6-4)thymidine photoproduct (2000)

Solar ultraviolet (UV) radiation induces DNA photoproducts in skin cells and is the predominant cause of human skin cancers. To understand human susceptibility to skin cancer and to facilitate the development of prevention measures, highly specific reagents to detect and quantitate UV-induced DNA adducts in human skin will be needed. One approach towards this end is the use of monoclonal antibody-based molecular dosimetry methods. To facilitate the development of photoproduct-specific antibody reagents we have: (i) cloned and sequenced a single chain variable fragment (ScFv) gene coding for one such high affinity monoclonal antibody, [alpha]UVssDNA-1 (mAb C3B6), recognizing the thymidine(6-4)thymidine photoproduct; (ii) expressed and displayed the cloned ScFv gene on the surface of phage; (iii) selected functional recombinant phage by panning; (iv) purified the ScFv peptide; (v) shown that the purified ScFv peptide binds to UV-irradiated polythymidylic acid but not unirradiated polythymidylic acid. This is the first demonstration of the use of phage display to select a ScFv recognizing DNA damage. In addition, this is the initial step towards immortalizing the antibody gene for genetic manipulation, structure-function studies and application to human investigations.
Photostabilization of a Nitromethylene Heterocycle Insecticide on the Surface of Montmorillonite (1988)

Abstract The photochemical stability of the insecticidal compound tetrahydro-2-(nitromethylene)-2H-1,3-thiazine (NMH) adsorbed on montmorillonite (Mont), in the presence or in the absence of a second organic chromophore was studied. Two different organic dyes were investigated as possible stabilizers of NMH: the divalent cation methyl green (MG) and the monovalent cation thioflavin T (TFT). Samples of free NMH and of the adsorption complexes Mont-NMH, Mont-MG-NMH, and Mont-TFT-NMH were exposed to direct sunlight, and the residual insecticidal activity was estimated. Some photostabilization of the pesticide adsorbed to the clay was observed. The highest degree of photoprotection was achieved in samples containing 0.5 mmole of TFT and 0.2 mmole of NMH/g clay. Increasing the load of TFT to 0.8 mmole/g clay resulted in a complete loss of photostabilization. The interactions of the organic molecules at the clay surface were studied by UV-VIS absorption and Fourier-transform infrared spectroscopy. For the Mont-NMH and Mont-MG-NMH complexes, the observed photostabilization is probably due to clay-NMH interactions. In the Mont-TFT-NMH complex specific interactions between the cationic dye and the pesticide molecules probably occurred as well.
ChemInform Abstract: New Vistas in Zeolite and Molecular Sieve Catalysis (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Microbial/enzymatic synthesis of chiral pharmaceutical intermediates. (2003)

Chirality is a key factor in the efficacy of many drugs; thus, the production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. Chiral intermediates and fine chemicals are in high demand from the pharmaceutical and agrochemical industries for the preparation of bulk drug substances and agricultural products. There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivity. In this article, biocatalytic processes for the synthesis of chiral pharmaceutical intermediates are described.
THE NEW SLS BEAM SIZE MONITOR, FIRST RESULTS ∗ (2013)

An extremely small vertical beam size of 3.6 μm, corre- sponding to a vertical emittance of 0.9 pm, only about five times bigger than the quantum limit, has been achieved at the storage ring of the Swiss Light Source (SLS). The mea- surement was performed by means of a beam size moni- tor based on the imaging of the vertically polarized syn- chrotron radiation in the visible and UV spectral ranges. However, the resolution limit of the monitor was reached during the last measurement campaign and prevented fur- ther emittance minimization. In the context of the work package SLS Vertical Emittance Tuning of the TIARA col- laboration, a new improved monitor was built. It provides larger magnification, an increase of resolution and enables two complementary methods of measurement: imaging and interferometry. In this paper we present the design, installation, commissioning, performance studies and first results obtained with the new monitor.
On the interaction of second sound shock waves and vorticity in superfluid helium (1984)

Two second sound shock waves were propagated successively into initially quiescent superfluid helium. With long separation times the waveforms are identical, but with shorter times the flow behind the second shock decays anomalously, revealing the presence of fluid disturbances produced near the heater by the first pulse. In order to study the vortical nature of these disturbances, second sound shocks were produced in rotating superfluid helium. Propagation of shocks both along and normal to the axis of rotation was studied, the former case proving to be similar to the experiment with successive shocks.
Tests in adaptive regression via the Kac-Rice formula (2013)

We derive an exact p-value for testing a global null hypothesis in a general adaptive regression problem. The general approach uses the Kac-Rice formula, as described in (Adler &amp; Taylor 2007). The resulting formula is exact in finite samples, requiring only Gaussianity of the errors. We apply the formula to the lasso, group lasso, and principal components and matrix completion problems. In the case of the lasso, the new test relates closely to the recently proposed covariance test of Lockhart et al. (2013).
The Controversy of Cranial Bone Motion (1997)

Cranial bone motion continues to stimulate controversy. This controversy affects the general acceptance of some intervention methods used by physical therapists, namely, cranial osteopathic and craniosacral therapy techniques. Core to these intervention techniques is the belief that cranial bone mobility provides a compliant system where somatic dysfunction can occur and therapeutic techniques can be applied. Diversity of opinion over the truth of this concept characterizes differing viewpoints on the anatomy and physiology of the cranial complex. Literature on cranial bone motion was reviewed for the purpose of better understanding this topic. Published research overall was scant and inconclusive. Animal and human studies demonstrate a potential for small magnitude motion. Physical therapists should carefully scrutinize the literature presented as evidence for cranial bone motion. Further research is needed to resolve this controversy. Outcomes research, however, is needed to validate cranial bone mobilization as an effective treatment.