gebhart/patrepeval huggingface dataset:
A Monoclonal Antibody That Reacts with Nonallelic Enzyme Glycoproteins (1982)

One of six monoclonal antibodies raised against purified human placental alkaline phosphatase cross-reacts with the adult and fetal forms of intestinal alkaline phosphatase. The placental and intestinal enzymes are nonallelic. A new electrophoretic titration procedure was used to assess the relative reactivities of the different enzymes with the antibody. The placental enzyme was the most reactive. However, the adult intestinal enzyme showed greater reactivity than the fetal enzyme. The determinants to which the antibody binds on these three forms of alkaline phosphatase presumably differ in their detailed molecular configurations.
Electron Holography on Charging Effect in Non-Conductive Materials (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Finite-number-of-periods holographic gratings with finite-width incident beams: analysis using the finite-difference frequency-domain method (2002)

The effects of finite number of periods (FNP) and finite incident beams on the diffraction efficiencies of holographic gratings are investigated by the finite-difference frequency-domain (FDFD) method. Gratings comprising 20, 15, 10, 5, and 3 periods illuminated by TE and TM incident light with various beam sizes are analyzed with the FDFD method and compared with the rigorous coupled-wave analysis (RCWA). Both unslanted and slanted gratings are treated in transmission as well as in reflection configurations. In general, the effect of the FNP is a decrease in the diffraction efficiency with a decrease in the number of periods of the grating. Similarly, a decrease in incident-beam width causes a decrease in the diffraction efficiency. Exceptions appear in off-Bragg incidence in which a smaller beam width could result in higher diffraction efficiency. For beam widths greater than 10 grating periods and for gratings with more than 20 periods in width, the diffraction efficiencies slowly converge to the values predicted by the RCWA (infinite incident beam and infinite-number-of-periods grating) for both TE and TM polarizations. Furthermore, the effects of FNP holographic gratings on their diffraction performance are found to be comparable to their counterparts of FNP surface-relief gratings.
Aspects on simulation of switched bond graphs (2002)

By mode-switching systems we mean physical systems characterized by transitions which are at least an order of magnitude faster than the overall time-scale. There are essentially two different ways to model such systems for simulation. One is to employ continuous models and stiff solvers. This approach is becoming more feasible as more sophisticated stiff solvers become available, but still suffers from poor performance for larger models. An alternative approach is to employ hybrid models with instantaneous transitions between continuous mode-model, In this case solvers capable of detecting zero-crossings are required. The advantage of this approach is an improved simulation performance but the disadvantage is that one has to deal with more complex models. To handle the model complexity matter we have previously proposed switched bond graphs as a solution. Employing switched bond graphs, the problem of complex models is modified to the problem of translating the bond graph to a computational model. This is the problem addressed here.
Metabolic engineering with ATP-citrate lyase and nitrogen source supplementation improves itaconic acid production in Aspergillus niger (2019)

Ultimately, this study shows that metabolic engineering of ACL in our rewired IA biosynthesis pathway leads to improved IA production in <i>A. niger</i> due to an increase in glycolytic flux. Furthermore, IA fermentation conditions were improved by nitrogen supplementation that alleviates IA induced weak-acid stress and extends the idiophase.
Javascript Manual of Style (1996)

Add cutting-edge interactivity to Web pages with this bare bones guide to JavaScript programming! Scripts can be downloaded from the Ziff-Davis Press Web site -- Examples show before-and-after effects of coding so that programmers can reuse code in multiple areas of documents -- Overflowing with valuable information for the JavaScript programmer
FatTire (2013)

This paper presents FatTire, a new language for writing fault-tolerant network programs. The central feature of this language is a new programming construct based on regular expressions that allows developers to specify the set of paths that packets may take through the network as well as the degree of fault tolerance required. This construct is implemented by a compiler that targets the in-network fast-failover mechanisms provided in recent versions of the Open- Flow standard, and facilitates simple reasoning about network programs even in the presence of failures. We describe the design of FatTire, present algorithms for compiling FatTire programs to OpenFlow switch configurations, describe our prototype FatTire implementation, and demonstrate its use on simple examples.
Exploring the Privacy-Preserving Properties of Word Embeddings: Algorithmic Validation Study (Preprint) (2020)

<sec> <title>BACKGROUND</title> Word embeddings are dense numeric vectors used to represent language in neural networks. Until recently, there had been no publicly released embeddings trained on clinical data. Our work is the first to study the privacy implications of releasing these models. </sec> <sec> <title>OBJECTIVE</title> This paper aims to demonstrate that traditional word embeddings created on clinical corpora that have been deidentified by removing personal health information (PHI) can nonetheless be exploited to reveal sensitive patient information. </sec> <sec> <title>METHODS</title> We used embeddings created from 400,000 doctor-written consultation notes and experimented with 3 common word embedding methods to explore the privacy-preserving properties of each. </sec> <sec> <title>RESULTS</title> We found that if publicly released embeddings are trained from a corpus anonymized by PHI removal, it is possible to reconstruct up to 68.5% (n=411/600) of the full names that remain in the deidentified corpus and associated sensitive information to specific patients in the corpus from which the embeddings were created. We also found that the distance between the word vector representation of a patient’s name and a diagnostic billing code is informative and differs significantly from the distance between the name and a code not billed for that patient. </sec> <sec> <title>CONCLUSIONS</title> Special care must be taken when sharing word embeddings created from clinical texts, as current approaches may compromise patient privacy. If PHI removal is used for anonymization before traditional word embeddings are trained, it is possible to attribute sensitive information to patients who have not been fully deidentified by the (necessarily imperfect) removal algorithms. A promising alternative (ie, anonymization by PHI replacement) may avoid these flaws. Our results are timely and critical, as an increasing number of researchers are pushing for publicly available health data. </sec>
On the architecture of a CAD framework: The NELSIS approach (1990)

In this paper we present the principles of the architecture of a CAD framework that puts a substantial added-value under the fingertips of the designer by organizing the design information and keeping track of the design evolution, and in addition permits integration of tools of different origin and achieves run-time efficiency.We provide a rationale for partitioning the design information into raw data and meta data, then we model the meta data and define the architecture of the framework. Key features of this framework are its high level services for tool integration and extensive browsing facilities for the designer. The principles presented have been implemented in the Nelsis IC Design System in which they have proven their usefulness and efficiency.
The impact of RFID, IIoT, and Blockchain technologies on supply chain transparency (2019)

Purpose The purpose of this paper is to assess the combined impact of radio frequency identification (RFID), Industrial Internet of Things (IIoT) and Blockchain technologies on supply chain transparency (SCT). Design/methodology/approach Data from 211 US manufacturing managers is analyzed using a covariance-based structural equation modeling methodology. Findings The structural model fits the data relatively well. RFID technology directly and positively impact both IIoT and Blockchain technologies which, in turn, directly and positively impact SCT. RFID technology indirectly affects SCT through both IIoT technology and Blockchain technology. Research limitations/implications This study is the first to empirically assess the impact of RFID, IIoT and Blockchain technologies on SCT. First-wave empirical studies must be replicated to support generalization of the findings. Practical implications This study provides empirical evidence to support the implementation of a combination of RFID, IIoT and Blockchain technologies as infrastructure necessary to achieve end-to-end SCT. Originality/value New measurement scales for IIoT technology utilization and Blockchain technology utilization are developed and assessed for validity and reliability. This is the first study to assess the combined impact of RFID, IIoT and Blockchain technologies on SCT.
Mediterraneols: a novel biologically active class of rearranged diterpenoid metabolites from Cystoseira mediterranea (Pheophyta) (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMediterraneols: a novel biologically active class of rearranged diterpenoid metabolites from Cystoseira mediterranea (Pheophyta)Christian Francisco, Bernard Banaigs, Jean Teste, and Adrien CaveCite this: J. Org. Chem. 1986, 51, 7, 1115–1120Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/jo00357a033https://doi.org/10.1021/jo00357a033research-articleACS PublicationsRequest reuse permissionsArticle Views171Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Line tension and reduction of apparent contact angle associated with electric double layers (2014)

The line tension of an electrolyte wetting a non-polar substrate is computed analytically and numerically. The results show that, depending on the value of the apparent contact angle, positive or negative line tension values may be obtained. Furthermore, a significant difference between Young's contact angle and the apparent contact angle measured several Debye lengths remote from the three-phase contact line occurs. When applying the results to water wetting highly charged surfaces, line tension values of the same order of magnitude as found in recent experiments can be achieved. Therefore, the theory presented may contribute to the understanding of line tension measurements and points to the importance of the electrostatic line tension. Being strongly dependent on the interfacial charge density, electrostatic line tension is found to be tunable via the pH value of the involved electrolyte. As a practical consequence, the stability of nanoparticles adsorbed at fluid-fluid interfaces is predicted to be dependent on the pH value. The theory is suited for future incorporation of effects due to surfactants where even larger line tension values can be expected.
Epigenetic compounds have minor effects on differentiation in human thyroid cancer cell lines but induce expression of genes involved in in vitro adaptation (2011)

info:eu-repo/semantics/nonPublished
Osteoprotegerin (OPG) Upregulation Activates Breast Stromal Fibroblasts and Enhances Their Pro-Carcinogenic Effects through the STAT3/IL-6 Signaling (2022)

Breast carcinomas are composed of cancer cells surrounded by various types of non-cancer cells such as fibroblasts. While active cancer-associated fibroblasts (CAFs) support tumor initiation and progression, quiescent breast stromal fibroblasts (BSFs) inhibit these effects through various cytokines such as osteoprotegerin (OPG). We showed here that OPG is upregulated in CAFs as compared to their adjacent normal tumor counterpart fibroblasts. Interestingly, breast cancer cells can upregulate OPG in BSFs in an IL-6-dependent manner through the IL-6/STAT3 pathway. When upregulated by ectopic expression, OPG activated BSFs through the NF-κB/STAT3/AUF1 signaling pathway and promoted their paracrine pro-carcinogenic effects in an IL-6-dependent manner. In addition, this increase in the OPG level enhanced the potential of BSFs to promote the growth of humanized orthotopic tumors in mice. However, specific OPG knock-down suppressed active CAFs and their paracrine pro-carcinogenic effects. Similar effects were observed when CAF cells were exposed to the pure recombinant OPG (rOPG) protein. Together, these findings show the importance of OPG in the activation of stromal fibroblasts and the possible use of rOPG or inhibitors of the endogenous protein to target CAFs as precision cancer therapeutics.
Complexation of Buffer Constituents with Neutral Complexation Agents: Part II. Practical Impact in Capillary Zone Electrophoresis (2013)

This article elucidates the practical impact of the complexation of buffer constituents with complexation agents on electrophoretic results, namely, complexation constant determination, system peak development, and proper separation of analytes. Several common buffers, which were selected based on the pH study in Part I of this paper series (Riesová, M.; Svobodová, J.; Tošner, Z.; Beneš, M.; Tesařová, E.; Gaš, B. Anal. Chem., 2013, DOI: 10.1021/ac4013804); e.g., CHES, MES, MOPS, Tricine were used to demonstrate behavior of such complex separation systems. We show that the value of a complexation constant determined in the interacting buffers environment depends not only on the analyte and complexation agent but it is also substantially affected by the type and concentration of buffer constituents. As a result, the complexation parameters determined in the interacting buffers cannot be regarded as thermodynamic ones and may provide misleading information about the strength of complexation of the compound of interest. We also demonstrate that the development of system peaks in interacting buffer systems significantly differs from the behavior known for noncomplexing systems, as the mobility of system peaks depends on the concentration and type of neutral complexation agent. Finally, we show that the use of interacting buffers can totally ruin the results of electrophoretic separation because the buffer properties change as the consequence of the buffer constituents' complexation. As a general conclusion, the interaction of buffer constituents with the complexation agent should always be considered in any method development procedures.
Ceramic Bearings in Total Knee Arthroplasty (2010)

Ceramic bearings have been used extensively in total hip arthroplasty, both in ceramic-on-polyethylene and in ceramic-on-ceramic articulations. Ceramic articulations in total hip arthroplasties offer the advantage of lower wear rates compared to the standard metal-polyethylene coupling. In total knee arthroplasty, few data have examined the application of ceramic bearings. The long-term failure mode of total knee arthroplasties is related to wear and failure of the polyethylene in the articulation. Wear data from knee simulators and in vitro investigations suggest ceramics may offer a superior countersurface in total knee bearings through decreased polyethylene wear rates and a lower incidence of long-term failures associated with wear. This article reviews the existing data related to the application of ceramic biomaterials in total knees and evaluates the role ceramic surfaces may have in extending the longevity of total knee arthroplasty.
Krieg Cortical Kudos (1992)

Krieg Cortical Kudos: 1992 Krieg Cortical Kudos Awards Presented at the Cajal Club Get access P. Rakic P. Rakic Search for other works by this author on: Oxford Academic PubMed Google Scholar Cerebral Cortex, Volume 2, Issue 2, March 1992, Pages 176–179, https://doi.org/10.1093/cercor/2.2.176 Published: 01 March 1992
Algorithm for computing minimum product distance of TCM codes (1992)

In fading channels, the minimum product distance of a trellis code plays an important role in error rate performance. In the Letter, an algorithm for computing the minimum product distance and its multiplicity is introduced. The algorithm is applied to search for best trellis codes on fading channels.
Recent advances in carbocupration of α-heterosubstituted alkynes (2010)

Carbocupration of α-heterosubstituted alkynes leads to the formation of stereodefined functionalized vinyl copper species as single isomer. Recent advances in the field show that a simple pre-association of the organometallic derivative with an additional polar functional group in the vicinity of the reaction center may completely change the stereochemical outcome of the reaction. Representative examples are given in this mini-review.
Geospatial data quality (ISO 19157-1): evolve or perish (2020)

Given the circumstance that the process for the revision of the international standard ISO 19157 is currently open, this article presents a critical reflection on its content, application and some challenges posed by the new types of data (e.g. big data, BIM data, etc.), that also have a geospatial component and to which, therefore, this international standard can be applied as well. Proposals are put forward going along three lines of improvement, on the one hand the consideration of new data quality elements and on the other, the reinforcement of the interoperability of this international standard with other standards related to data quality, and finally various improvements (e.g. standardization of evaluation methods, clearly introducing the life cycle, improvement of the definition of metaquality, etc.) of the standard, which come from experience.
On the Physical Layer Security of IoT Devices over Satellite (2019)

The security in satellite communications is a key issue due to the large footprint of the beams. This is specially critical in IoT devices that transmit data directly to satellite. Take into account that IoT devices are characterized by transmitting packets of short length. Consequently, it means that it is not feasible to augment the security level of the IoT packets via complex cryptographic algorithms. Otherwise, their packet lengths may be increased in a non-negligible way which could augment their collision probabilities, latencies and energy consumptions. For this reason, this paper proposes to take advantage of the time-packing technique. By doing so, it is possible to use the overlapping degree among the pulse-shapes to boost the secrecy-capacity. In particular, the overlapping degree between the pulse-shapes introduces an artificial interference that degrades the eavesdropper's channel. In this regard, it is necessary to highlight that there is a residual co-channel interference in the satellite beams. So, it means that these two sources of impairments make difficult to estimate the legitimate user's transmission parameters by the eavesdropper.
Integration of a phase change material for junction-level cooling in GaN devices (2012)

Next generation gallium nitride (GaN) RF power transistors offer higher power, higher efficiency and wider bandwidth than competing Si technologies. However, the high power densities available in GaN power transistors create new challenges for heat dissipation. This paper presents a novel micro-scale thermal storage design that involves phase change material (PCM) filled grooves etched in the substrate to remove the heat generated in the active regions of a pulsed-mode GaN transistor. High electron mobility transistors (HEMTs) were fabricated on a GaN-on-Si wafer. Backside patterning and etching were done to thin the Si substrate under the active channel region of the selected transistors. A phase change material (PCM) with a melting temperature of 118°C was deposited in the etched grooves. Electrical measurements were carried out to compare the performance of transistors with and without PCM filled grooves. It was found that the groove etching did not degrade the transistor performance under low power conditions where the junction level heating is not enough to start the PCM melting process. From the current-voltage characteristics at different temperatures ranging from 25°C to 120°C, it was found that at higher temperatures, the current density in the PCM-enabled device was larger than in the reference device, due to the enhanced thermal management. The role of PCM was confirmed when measurements at temperatures well above the melting temperature of the PCM did not show signs of increase in the current density. The maximum current density in the device with PCM material was found to be much more stable under pulsed conditions than in current state-of-the-art devices.
Dealing with Metonymic Readings of Named Entities (2006)

The aim of this paper is to propose a method for tagging named entities (NE), using natural language processing techniques. Beyond their literal meaning, named entities are frequently subject to metonymy. We show the limits of current NE type hierarchies and detail a new proposal aiming at dynamically capturing the semantics of entities in context. This model can analyze complex linguistic phenomena like metonymy, which are known to be difficult for natural language processing but crucial for most applications. We present an implementation and some test using the French ESTER corpus and give significant results.
Quantitative in vivo evaluation of four restorative concepts for mixed Class V restorations. (1991)

This study was performed in vivo over a 6-month period to assess restorative margins in Class V restorations placed with different techniques. The margins were evaluated quantitatively under the scanning electron microscope using the replica technique. Results indicated that the sandwich technique using a glass-ionomer cement base and a composite resin restoration was not able to prevent marginal gaps in dentin. However, the experimental Gluma/Clearfil system resulted in a quality of dentinal margins not statistically significantly different from that of enamel margins. These in vivo findings substantiate in vitro results.