gebhart/patrepeval huggingface dataset:
Determination of the preferred tautomeric form of 4‐nitrohistidine (1986)

Abstract Spectrophotometric p Ka determinations of methyl derivatives of N α ‐acetyl‐4‐nitrohistidine methyl ester 1 have been used to determine the position of the tautomeric equilibrium of 1 . The N 1 ‐H tautomer is the predominant form with an equilibrium constant K T of 48. The conclusion is supported qualitatively by the study of 1 H‐nmr and 13 C‐nmr chemical shifts of the imidazole ring atoms and their changes from neutral to acidic media.
Evaluation of Selected Chemotypes in Coupled Cellular and Molecular Target-Based Screens Identifies Novel HIV-1 Zinc Finger Inhibitors (1996)

Conservation of the Cys-Xaa2-Cys-Xaa4-His-Xaa4-Cys retroviral zinc finger sequences and their absolute requirement in both the early and late phases of retroviral replication make these chemically reactive structures prime antiviral targets. We recently reported that select 2,2'-dithiobisbenzamides (DIBAs) chemically modify the zinc finger Cys residues, resulting in release of zinc from the fingers and inhibition of HIV replication. In the current study we surveyed 21 categories of disulfide-based compounds from the chemical repository of the National Cancer Institute for their capacity to act as retroviral zinc finger inhibitors. Aromatic disulfides that exerted anti-HIV activity tended to cluster in the substituted aminobenzene, benzoate, and benzenesulfonamide disulfide subclasses. Only one thiuram derivative exerted moderate anti-HIV activity, while a number of nonaromatic thiosulfones and miscellaneous disulfide congeners were moderately antiviral. Two compounds (NSC 20625 and NSC 4493) demonstrated anti-cultures. The two compounds chemically modified the p7NC zinc fingers in two separate in vitro assays, and interatomic surface molecular modeling docked the compounds efficiently but differentially into the zinc finger domains. The combined efforts of rational drug selection, cell-based screening, and molecular target-based screening led to the identification of zinc finger inhibitors that can now be optimized by medicinal chemistry for the development of biopharmaceutically useful anti-HIV agents.
Rutile Formation in Hydrothermally Crystallized Nanosized Titania (1996)

The present study shows that peptization aids in the anatase‐rutile transformation in hydrothermally processed (250°C, 4000 kPa) titania sols produced by the hydrolysis of alkoxide. HREM images show the presence of nanocrystals of 25–55 nm size. The anatase‐rutile phase transformation in peptized titania is critically dependent on the conditions of hydrolysis such as the water/alkoxide concentration ratio and the size of the alkoxide. Hydrolysis of the ethoxide gave rise to a predominantly rutile phase whereas the isopropoxide and butoxide resulted in a predominantly anatase powder, under the same conditions of treatment. BET surface areas decrease from 107.1 to 68 m 2 /g when the alkoxide is changed from tert ‐butoxide to ethoxide for a given water/ alkoxide ratio.
Palladium-Catalyzed Oxyarylation, Azaarylation and &#945;-Arylation Reactions in the Synthesis of Bioactive Isoflavonoid Analogues (2015)

Isoflavonoids constitute an important class of natural products, comprising great structural diversity. Known as phytoalexins and phytoestrogens, these compounds exhibit interesting biological activities. The corresponding carba-analogues, in which the oxygen atom at the B-ring is replaced by a methylene, are emerging as an attractive alternative for the preparation of new bioactive compounds. In this review, we report our results on the synthesis of isoflavonoid analogues (5-carba-pterocarpans, 1-carba-isoflavanones, 5-carba-11-aza-pterocarpan and pterocarpanquinones) with anti-cancer, antiparasitic and anti-viral properties. Palladium-catalyzed oxyarylation and azaarylation of dihydronaphthalenes and α-arylation of α- tetralones were the key steps in the developed synthetic approaches. A historical background, as well as a brief mechanistic discussion of these reactions, will be presented. Keywords: Isoflavonoids, Carba-isoflavonoids, Oxyarylation, Azaarylation, α-Arylation, Palladium-catalyzed.
Paper Session III-B - Soybean and Corn Seed Germination in Space: The First Plant Study Conducted on Space Station Alpha (2001)

The JOSE (JASON Outreach Seed Experiment) payload was the first plant study conducted on Space Station Alpha. The experiment consisted of having an on-orbit watering of eight seed pouches, each of which contained either six soybean or six corn seeds glued to a germination paper substrate. Two pouches containing corn plus two pouches containing soybean seeds were maintained in the light after watering. Two additional seed pouches of each species were maintained in the dark after watering. Digital photography was used to document the growth of the germinating seedlings in space. The images were down-linked and posted to a world wide web site for dissemination to students. Details relating to the experimental design are presented. "Within" species differences (between the light and dark grown seedlings) as well as "between" species differences (comparing corn and soybean) were observed.
Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous System (2017)

Adeno-associated viruses (AAVs) have become highly promising tools for research and clinical applications in the central nervous system (CNS). However, specific delivery of genes to the cell type of interest is essential for the success of gene therapy and therefore a correct selection of the promoter plays a very important role. Here, AAV8 vectors carrying enhanced green fluorescent protein (eGFP) as reporter gene under the transcriptional control of different CNS-specific promoters were used and compared with a strong ubiquitous promoter. Since one of the main limitations of AAV-mediated gene delivery lies in its restricted cloning capacity, we focused our work on small-sized promoters. We tested the transduction efficacy and specificity of each vector after stereotactic injection into the mouse striatum. Three glia-specific AAV vectors were generated using two truncated forms of the human promoter for glial fibrillar acidic protein (GFAP) as well as a truncated form of the murine GFAP promoter. All three vectors resulted in predominantly glial expression; however we also observed eGFP expression in other cell-types such as oligodendrocytes, but never in neurons. In addition, robust and neuron-specific eGFP expression was observed using the minimal promoters for the neural protein BM88 and the neuronal nicotinic receptor β2 (CHRNB2). In summary, we developed a set of AAV vectors designed for specific expression in cells of the CNS using minimal promoters to drive gene expression when the size of the therapeutic gene matters.
Modulation of the migration and chemotaxis of PMN cells by hyaluronic acid. (1989)

Hyaluronic acid (HA) has a dose-related inhibiting effect on the migration and chemotaxis of polymorphonuclear leucocytes (PMN) in vitro. These effects were measured with a new indirect quantitative assay. On average 1 mg HA/ml causes an inhibition to about 80% of the control (spontaneous migration). This effect increased progressively with an increasing HA concentration, and with 4 mg HA/ml only about 19% of the PMN were able to migrate in the in vitro system. Similar results were obtained in the presence of a potent chemotactic factor (leukotriene B4 [LTB4]). In the mean 1 ng LTB4/ml alone stimulated the chemotaxis of PMN by a factor of 3 compared to the spontaneous migration. The highest HA concentration (4 mg/ml) reduced the number of migrating PMN cells to about 17%. From these experiments it may be concluded that the HA in the synovial fluid of the healthy joint has a protective effect against the invasion of PMN cells. This functions is disturbed in inflamed joints by the decrease in the HA concentration and possibly by its depolymerization. The intraarticular application of high molecular weight HA might be an important therapeutic regimen to restore the natural barrier against PMN migration, also in the presence of chemotactic factors and could therefore be helpful for interrupting the inflammatory cascade.
The Thermodynamic Properties of Liquid Ternary Cadmium Solutions1 (1951)

The ternary systems cadmium-lead-bismuth, cadmium-lead-antimony and cadmium-lead-tin have been investigated by electrode-potential methods over the temperature interval of 380 to 600°. The properties, ΔF<sup>x</sup>, ΔS<sup>x</sup>, ΔH, Δ$F^\mathrm{x}_\mathrm{i}$, L<sub>i</sub> and activities are computed for the three ternary solutions and the lead-tin binary solution at 500°. Finally, they are best summarized by reference to the appropriate figures in the text.
Different Molecular Cascades in Different Sites of the Brain Control Memory Consolidation (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Remote Manipulation of Guidewire Using a Virtual Reality Device (2001)

A trial of remote manipulation for micro guidewire is reported. The system had masterslave style. When an operator manipulated the virtual torque device at the master side, a machine at the distant slave side reproduced the manipulation. At the same time, the operator could feel the force feedback from the manipulation at the slave. We could experimentally realize this remote manipulating system using a virtual reality device.
Investigation of cold nuclear fusion in condensed matter. Final report (1992)

Recent research has been directed towards finding means to produce neutron emissions at will, to demonstrate reproducibility, and to permit in-depth studies of the origin of neutron emissions. this goal has been pursued in the Kamiokande detector in Japan and has led to the development of a deep underground laboratory in a tunnel in the Wasatch mountains near Brigham Young University. New counters for low-level neutron emissions are being utilized. Calorimetric tools have also been developed.
Diphenylprolinol Silyl Ether as a Catalyst in an Asymmetric, Catalytic, and Direct Michael Reaction of Nitroethanol with α,β-Unsaturated Aldehydes (2009)

Diphenylprolinol silyl ether was found to be an effective organocatalyst in the enantioselective and direct Michael reaction of nitroethanol and α,β-unsaturated aldehydes, affording the 1-hydroxy-trans-3,4-disubstituted tetrahydropyrans after isomerization. The generated Michael addition products are useful synthetic intermediates, which can be converted into chiral tetrahydropyran with a quaternary stereocenter, 3-substituted cis- and trans-prolines, and α-amino acid derivatives.
Complex Left Atrial Appendage Morphology and Left Atrial Appendage Thrombus Formation in Patients With Atrial Fibrillation (2014)

Complex LAA morphology characterized by an increased number of LAA lobes was associated with the presence of LAA thrombus independently of clinical risk and blood stasis. This study suggests that LAA morphology might be a congenital risk factor for LAA thrombus formation in patients with AF.
Activated Signal Transducers and Activators of Transcription 3 Signaling Induces CD46 Expression and Protects Human Cancer Cells from Complement-Dependent Cytotoxicity (2007)

CD46 is one of the complement-regulatory proteins expressed on the surface of normal and tumor cells for protection against complement-dependent cytotoxicity. Cancer cells need to access the blood circulation for continued growth and metastasis, thus exposing themselves to destruction by complement system components. Previous studies have established that the signal transducers and activators of transcription 3 (STAT3) transcription factor is persistently activated in a wide variety of human cancer cells and primary tumor tissues compared with their normal counterparts. Using microarray gene expression profiling, we identified the CD46 gene as a target for activated STAT3 signaling in human breast and prostate cancer cells. The CD46 promoter contains two binding sites for activated STAT3 and mutations introduced into the major site abolished STAT3 binding. Chromatin immunoprecipitation confirms binding of STAT3 to the CD46 promoter. CD46 promoter activity is induced by activation of STAT3 and blocked by a dominant-negative form of STAT3 in luciferase reporter assays. CD46 mRNA expression is induced by interleukin-6 and by transient transfection of normal human epithelial cells with a persistently active mutant construct of STAT3, STAT3C. Furthermore, we show that inhibition of STAT3-mediated CD46 cell surface expression sensitizes DU145 prostate cancer cells to cytotoxicity in an in vitro complement lysis assay using rabbit anti-DU145 antiserum and rabbit complement. These results show that activated STAT3 signaling induces the CD46 promoter and protects human cancer cells from complement-dependent cytotoxicity, suggesting a potential mechanism whereby oncogenic signaling contributes to tumor cell evasion of antibody-mediated immunity.
Comparison of the thermo-mechanical treatments of some steels conducted at a pilot plant and by physical simulation (1992)

Comparison of the thermo-mechanical treatments of some steels conducted at a pilot plant and by physical simulation
Pruritus of patients with atopic dermatitis in daily life and their experience of therapeutic effects: results of a web-based questionnaire survey (2014)

Journal Article Pruritus of patients with atopic dermatitis in daily life and their experience of therapeutic effects: results of a web‐based questionnaire survey Get access S. Takeuchi, S. Takeuchi Department of Dermatology Graduate School of Medical Sciences Kyushu University 3‐1‐1 Maidashi Higashi‐ku Fukuoka 812‐8582 JapanDepartment of Dermatology Federation of National Public Service Personnel Mutual Aid Associations Hamanomachi Hospital 3‐3‐1 Nagahama Chuo‐ku Fukuoka 810‐8539 Japan Search for other works by this author on: Oxford Academic Google Scholar J. Oba, J. Oba Department of Dermatology Graduate School of Medical Sciences Kyushu University 3‐1‐1 Maidashi Higashi‐ku Fukuoka 812‐8582 Japan Search for other works by this author on: Oxford Academic Google Scholar H. Esaki, H. Esaki Department of Dermatology Graduate School of Medical Sciences Kyushu University 3‐1‐1 Maidashi Higashi‐ku Fukuoka 812‐8582 Japan Search for other works by this author on: Oxford Academic Google Scholar M. Furue M. Furue Department of Dermatology Graduate School of Medical Sciences Kyushu University 3‐1‐1 Maidashi Higashi‐ku Fukuoka 812‐8582 Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 173, Issue 1, 1 July 2015, Pages 250–252, https://doi.org/10.1111/bjd.13557 Published: 01 July 2015
On recognition of human orientation with respect to a static camera (2013)

Detection of orientation of a human being with respect to a static camera is an important problem in computer vision. This paper proposes a method for detection of orientation of a human being from four different orientations (e.g. front, side-left, side-right, back) with respect to a static camera. In the proposed method, extraction of features of a human being has been performed in terms of boundary description known as the signature. A template database of four different human orientations has been created. The extracted features of a testing sample have been compared with that stored in the template database and a dissimilarity value has been calculated. The classification has been performed using the dissimilarity value as a metric. The results obtained are encouraging.
A Modular Approach for a Family of Ground Mobile Robots (2013)

This paper deals with Epi.q, a family of mobile robots whose main characteristic is a wheel-legged hybrid locomotion. These multi-purpose robots can be successfully exploited for security and surveillance tasks. The document presents state of the art security robotics, the Epi.q mechanical architecture, the concept behind the robot driving unit, three prototypes and the design of a new one.
Revised Crystal Structure Model of Li2NH by Neutron Powder Diffraction (2005)

We performed neutron powder diffraction experiments on lithium imide Li2NH, and have proposed a revised crystal structure model. Li2NH has a face-centered cubic structure with a partially occupied hydrogen site. Of the possible crystal structure models that represent the obtained data, the model with F-43m symmetry having hydrogen atoms at the 16e site, in which only one hydrogen atom randomly occupies one of the four hydrogen positions around a nitrogen atom, is most probable. For this model, the distance between the nearest nitrogen and hydrogen atoms is 0.82(6)A, and the angle between H-N-H is 109.5deg., which are close to those of the lithium amide LiNH2, indicating that the structural circumstances around nitrogen and hydrogen are similar in Li2NH and LiNH2.
Non-Small Cell Lung Cancer from Genomics to Therapeutics: A Framework for Community Practice Integration to Arrive at Personalized Therapy Strategies (2020)

Non-small cell lung cancer (NSCLC) is a heterogeneous disease, and therapeutic management has advanced with the identification of various key oncogenic mutations that promote lung cancer tumorigenesis. Subsequent studies have developed targeted therapies against these oncogenes in the hope of personalizing therapy based on the molecular genomics of the tumor. This review presents approved treatments against actionable mutations in NSCLC as well as promising targets and therapies. We also discuss the current status of molecular testing practices in community oncology sites that would help to direct oncologists in lung cancer decision-making. We propose a collaborative framework between community practice and academic sites that can help improve the utilization of personalized strategies in the community, through incorporation of increased testing rates, virtual molecular tumor boards, vendor-based oncology clinical pathways, and an academic-type singular electronic health record system.
Microsurgical Resection of Brainstem Arteriovenous Malformation: 2-Dimensional Operative Video (2019)

Brainstem arteriovenous malformations (AVMs) are rare lesions (2%-6% of all intracranial AVMs) that are surgically challenging because of the high eloquence of the brainstem, including dense fiber tracts, cranial nerves, and multiple vital cerebrovascular structures. All these lesions possess eloquence and deep venous drainage, making them innately Spetlzer-Martin grade III or above. This patient had a large midbrain AVM with a complex clinical course beginning with ventriculoperitoneal shunting due to mass effect; the patient experienced 4 hemorrhages, underwent radiation treatment, and finally underwent surgical resection. The surgical approach involved a large torcular craniotomy exposing all posterior sinuses at the confluence. The vein of Galen was exposed and carried deeply to permit ambient cistern opening and relaxation of the cerebellum. Because of earlier radiation therapy, the vessels had undergone hyalinosis, which resulted in difficult manipulation of the nidus but did permit excellent coagulation of the vessels. The complete nidus was removed, as confirmed on postoperative angiography. The patient gave informed consent for surgery and video recording. Institutional review board approval was deemed unnecessary. Used with permission from Barrow Neurological Institute, Phoenix, Arizona.
A type-2 fuzzy logic controller for dynamic positioning systems (2010)

This paper presents an approach to design type- 2 fuzzy logic controllers (FLCs) for dynamic positioning (DP) systems, and the design process can be easily extended to other multi-input multi-output (MIMO) systems with coupling between loops. The combination of FLCs and nonlinear observers removes the need to linearize the kinematic equations of motion when designing control systems for the DP systems. Simulations with a supply vessel demonstrate the performance of the proposed controller. Comparisons show that the type-2 FLC outperform the linear quadratic regulator (LQR) controller and is more robust. In the face of disturbances, the type-2 FLC has better disturbance rejection property than its type-1 counterpart.
A transition-metal–rare-earth alloy for perpendicular magnetic recording (1983)

Several Co-based media have been recognized to be convenient for perpendicular magnetic recording. These alloys present a good perpendicular magnetic anisotropy and high saturation magnetization, but high demagnetizing fields and a poor perpendicular hysteresis loop squareness σ⊥. This paper describes the conditions of deposition, magnetic properties, and recording tests results obtained with radio-frequence diode-sputtered FeTbGd thin films. Near to the compensation composition, the saturation magnetization and demagnetizing fields are low and σ⊥ is nearly 1. A SiO2 protective layer covered medium has been tested for magnetic recording with a conventional Winchester ferrite head. In these recording conditions, a density as high as 162 kiloflux changes per inch has been obtained. Such results show that transition-metal–rare-earth (TM-RE) alloys are suitable for perpendicular magnetic recording.
Role of the Novel OprD Family of Porins in Nutrient Uptake in Pseudomonas aeruginosa (2005)

To circumvent the permeability barrier of its outer membrane, Pseudomonas aeruginosa has evolved a series of specific porins. These channels have binding sites for related classes of molecules that facilitate uptake under nutrient-limited conditions. Here, we report on the identification of a 19-member family of porins similar to the basic-amino-acid-specific porin OprD. The members of this family fell into one of two phylogenetically distinct clusters, one bearing high similarity to OprD and the other bearing most similarity to the putative phenylacetic acid uptake porin PhaK of Pseudomonas putida. Analysis of the genome context, operon arrangement, and regulation of the PhaK-like porin OpdK indicated that it might be involved in vanillate uptake. This result was confirmed by demonstrating that an opdK mutant had a deficiency in the ability to grow on vanillate as a carbon source. To extrapolate these data to other paralogues within this family, the substrate specificities of 6 of the 17 remaining OprD homologues were inferred using an approach similar to that used with opdK. The specificities determined were as follows: OpdP, glycine-glutamate; OpdC, histidine; OpdB, proline; OpdT, tyrosine; OpdH, cis-aconitate; and OpdO, pyroglutamate. Thus, members of the OprD subfamily took up amino acids and related molecules, and those characterized members most similar to PhaK were responsible for the uptake of a diverse array of organic acids. These results imply that there is a functional basis for the phylogenetic clustering of these proteins and provide a framework for studying OprD homologues in other organisms.