gebhart/patrepeval huggingface dataset:
I40 Number needed to harm (NNH) analysis of deutetrabenazine (DTB) and tetrabenazine (TBZ) from two pivotal trials: First-HD and Tetra-HD (2016)

<h3>Background</h3> DTB was efficacious and well tolerated in patients with Huntington’s disease (HD) chorea (First-HD). In the absence of a head-to-head trial with TBZ, we compared safety and tolerability outcomes of TBZ versus DTB using an indirect treatment comparison method and an NNH metric. <h3>Methods</h3> Safety data from First-HD and TETRA-HD were used to calculate the NNH, where serious adverse events (SAEs), discontinuation (all cause- and adverse event [AE]-related), and specific AEs (in &gt; 10% of patients) were defined as undesirable outcomes. The difference between the proportions of undesirable outcomes was estimated by subtracting the applicable placebo-adjusted risk from both studies (TETRA-HD minus First-HD). NNH estimates, defined as the number of patients to be treated with TBZ instead of DTB for an average of one additional patient to experience an AE, were calculated as the inverses of the risk differences. P-values were obtained from z-tests, which approximate normal distribution. <h3>Results</h3> First-HD (N = 90) and TETRA-HD (N = 84) cohorts were of similar age (53.7 years vs 49.2 years) and gender (proportion of females 44% vs 62%), and baseline chorea scores were 12.7 vs 14.9. TBZ demonstrated a significant NNH vs DTB of 3 (95% CI: 1, 8; P &lt; 0.01) for moderate to severe AEs, meaning that, if three patients were treated with TBZ instead of DTB, then one more patient, on average, would experience a moderate to severe AE. TBZ had a significant (all P ≤ 0.02) NNH vs DTB of 5 (95% CI: 3, 15) for depression, 5 (95% CI: 3, 15) for akathisia, 7 (95% CI: 4, 19) for Parkinsonism, 5 (95% CI: 3, 27) for somnolence, 4 (95% CI: 3, 12) for insomnia, and 8 (95% CI: 4, 46) for agitation. No other AEs analysed were significant. <h3>Conclusions</h3> In this NNH analysis, DTB demonstrated significantly better outcomes than TBZ on several safety measures. Further analysis adjusting for demographic differences between trials should be conducted to confirm these findings.
Principles and Criteria of Vibration Isolation of Machinery (1979)

This paper considers a complex of problems connected with the systematic approach to vibration isolation of production machinery. After general classification of machinery and the formulation of typical features of a dynamic vibroisolation system of machinery, criteria of effective isolation for main groups of machinery are derived. Designs of isolators complying with these criteria are described.
Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology (2020)

The general anesthetic ketamine has been repurposed by physicians as an anti-depressant and by the public as a recreational drug. However, ketamine use can cause extensive pathological changes, including ketamine cystitis. The mechanisms of ketamine's anti-depressant and adverse effects remain poorly understood. Here we present evidence that ketamine is an effective L-type Ca<sup>2+</sup> channel (Cav1.2) antagonist that directly inhibits calcium influx and smooth muscle contractility, leading to voiding dysfunction. Ketamine prevents Cav1.2-mediated induction of immediate early genes and transcription factors, and inactivation of Cav1.2 in smooth muscle mimics the ketamine cystitis phenotype. Our results demonstrate that ketamine inhibition of Cav1.2 signaling is an important pathway mediating ketamine cystitis. In contrast, Cav1.2 agonist Bay k8644 abrogates ketamine-induced smooth muscle dysfunction. Indeed, Cav1.2 activation by Bay k8644 decreases voiding frequency while increasing void volume, indicating Cav1.2 agonists might be effective drugs for treatment of bladder dysfunction.
Reduced exploratory behavior in neuronal nucleoredoxin knockout mice (2021)

Nucleoredoxin is a thioredoxin-like redoxin that has been recognized as redox modulator of WNT signaling. Using a Yeast-2-Hybrid screen, we identified calcium calmodulin kinase 2a, Camk2a, as a prominent prey in a brain library. Camk2a is crucial for nitric oxide dependent processes of neuronal plasticity of learning and memory. Therefore, the present study assessed functions of NXN in neuronal Nestin-NXN-/- deficient mice. The NXN-Camk2a interaction was confirmed by coimmunoprecipitation, and by colocalization in neuropil and dendritic spines. Functionally, Camk2a activity was reduced in NXN deficient neurons and restored with recombinant NXN. Proteomics revealed reduced oxidation in the hippocampus of Nestin-NXN-/- deficient mice, including Camk2a, further synaptic and mitochondrial proteins, and was associated with a reduction of mitochondrial respiration. Nestin-NXN-/- mice were healthy and behaved normally in behavioral tests of anxiety, activity and sociability. They had no cognitive deficits in touchscreen based learning & memory tasks, but omitted more trials showing a lower interest in the reward. They also engaged less in rewarding voluntary wheel running, and in exploratory behavior in IntelliCages. Accuracy was enhanced owing to the loss of exploration. The data suggested that NXN maintained the oxidative state of Camk2a and thereby its activity. In addition, it supported oxidation of other synaptic and mitochondrial proteins, and mitochondrial respiration. The loss of NXN-dependent pro-oxidative functions manifested in a loss of exploratory drive and reduced interest in reward in behaving mice.
Supplementary Data from Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response (2023)

Supplementary Data from Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response
Sorting and Transport of Alpha Herpesviruses in Axons (2001)

The alpha herpesviruses, a subfamily of the herpesviruses, are neurotropic pathogens found associated with most mammalian species. The prototypic member of this subfamily is herpes simplex virus type 1, the causative agent of recurrent cold sores in humans. The mild nature of this disease is a testament to the complex and highly regulated life cycle of the alpha herpesviruses. The cellular mechanisms used by these viruses to disseminate infection in the nervous system are beginning to be understood. Here, we overview the life cycle of alpha herpesviruses with an emphasis on assembly and transport of viral particles in neurons.
High Robustness S-Band GaN Based LNA (2019)

A robust full-MMIC S-band Low Noise Amplifier including power limiter based on envelope detector and Cold FET power reflector is presented. The robust LNA is based on 0.25μm UMS GaN technology and exhibits high Input Power-handling up to 40W over 2-4GHz bandwidth associated to measured Recovery Time lower than 0.5μs. Furthermore, the LNA noise figure performance is lower than 2dB with more than 22dB of small signal gain. These results are promising for the next frontend radar architectures.
Colorimetric Determination of Organic Peroxides (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTColorimetric Determination of Organic PeroxidesM. I. Eiss and Paul. GieseckeCite this: Anal. Chem. 1959, 31, 9, 1558–1560Publication Date (Print):September 1, 1959Publication History Published online1 May 2002Published inissue 1 September 1959https://pubs.acs.org/doi/10.1021/ac60153a038https://doi.org/10.1021/ac60153a038research-articleACS PublicationsRequest reuse permissionsArticle Views322Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
More brilliance from high-power laser diodes (2003)

The introduction of high power diode laser systems in industry has boosted the interest in these devices for a wide range of applications. Besides printing and soldering, cutting and deep penetration welding are becoming more important. An overview about the developments, an update on today's high power laser activities and an outlook will be given, what characteristics laser bars will have to fulfil in the near future. For higher brightness, laser bars with lower fill factors, monolithic integrated laser junctions and tapered laser designs were investigated. High power diode laser (HPDL) bars with 25% - 50% fill factor were operated between 40 W and 80 W and lifetimes up to 100 000 hours could be extrapolated. Tapered laser bars with 50W output power and high wall plug efficiencies were developed. Wavelength multiplexing and polarisation coupling were used in order to reach multi-kilo-Watt diode laser emission. Examples for applications will be given.
IHH Gene Mutations Causing Short Stature With Nonspecific Skeletal Abnormalities and Response to Growth Hormone Therapy (2017)

Our study demonstrated the association of pathogenic variants in IHH with short stature with nonspecific skeletal abnormalities and established a frequent cause of growth disorder, with a preliminary good response to rhGH.
Conformational transition pathway and free energy analyses of proteins by parallel cascade selection molecular dynamics (PaCS-MD) (2014)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Ryuhei Harada, Yasutaka Nishihara, Nobuhiko Wakai, Akio Kitao; Conformational transition pathway and free energy analyses of proteins by parallel cascade selection molecular dynamics (PaCS-MD). AIP Conf. Proc. 6 October 2014; 1618 (1): 86–89. https://doi.org/10.1063/1.4897682 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Enhancing radiation control of an optical leaky wave antenna in a resonator (2012)

We analyze the theoretical and physical properties of a CMOS compatible optical leaky wave antenna (OLWA) integrated into a Fabry-Pérot resonator (FPR) at 193.4 THz (wavelength<i> &lambda;</i><sub>0</sub> = 1550 nm). The presented OLWA design is composed of a silicon (Si) dielectric waveguide sandwiched between two silica glass (SiO<sub>2</sub>) domains, and it comprises periodic perturbations (cavities of vacuum). We first describe the radiation of the isolated OLWA whose radiation pattern is due to the excitation of a leaky wave, slowly decaying while traveling. The perturbations are indeed designed to obtain a leaky wave harmonic with very low attenuation and phase constants. Then, we integrate the same OLWA into a FPR where two leaky waves with the same wavenumber are travelling in opposite directions inside the resonator. We show that the radiation level at the broadside direction can be effectively controlled by modifying the optical properties of the Si waveguide through electron-hole excess carrier generation (found to be highly enhanced when it is integrated into a FPR). The design of the integrated OLWA is properly set to guarantee the constructive interference of the two radiated beams provided by the two leaky waves in the FPR. The modal propagation constant in the integrated OLWA can be then altered through excess carrier generation in Si, thus the antenna can be tuned in and out of the resonance thanks to the high FPR quality factor, and the LW modal dispersion relation. This allows for enhanced radiation level control at broadside, and preliminary results show up to 13 dB beam modulation.
New Oxidizing Reagent: Peroxysulfonimidoyl Intermediate Generated from Sulfonimidoyl Chloride and Superoxide (1989)

Abstract A new peroxysulfonimidoyl intermediate which is generated in situ from N-carbo-(-)-menthoxy-4-tolylsulfonimidoyl chloride and superoxide (O2 −−) in the presence of 18-crown-6-ether at 0°C in acetonitrile was found to have a good oxidizing ability for the selective oxidation of sulfides to the sulfoxides and for the epoxidation of olefins under mild conditions.
WHO'S WIRED FOR THE BRAVE NEW WORLD (2001)

This article describes some of the telematics applications that could be fitted in cars. There is debate among manufacturers as to how much of this technology is wanted by the driver, and sales are still slow. Some applications could have safety potential, such as location sensors; others business or social; and others provide information for the driver. However, manufacturers are reluctant to be the first to take the risk on providing such services. Voice activation is being brought back into cars for use in controlling telematics applications: the author speculates that voice control of a personal computer would be possible.
The Spectrum of Pheochromocytoma in Hypertensive Patients With Neurofibromatosis (1982)

We have found an appreciable number of pheochromocytomas in patients with neurofibromatosis and concurrent hypertension (ten of 18 cases). At diagnosis, the patient age range was 15 to 62 years, the clinical appearance of the neurofibromatosis did not predict who would and who would not have pheochromocytomas, but the age at diagnosis was helpful in that our younger patients tended to have causes of hypertension other than pheochromocytoma. However, several causes of hypertension may coexist. The biochemical findings were highly diagnostic. The pheochromocytomas secreted epinephrine as well as norepinephrine and resided in or next to the adrenal gland. Where pheochromocytoma is the cause of hypertension, its resection generally results in a better control of hypertension than that obtained in patients whose BPs were elevated from other unknown causes.
Syntheses, Structures, and Magnetic Properties of Diphenoxo-Bridged CuIILnIII and NiII(Low-Spin)LnIII Compounds Derived from a Compartmental Ligand (Ln = Ce−Yb) (2010)

Syntheses, characterization, and magnetic properties of a series of diphenoxo-bridged discrete dinuclear MIILnIII complexes (M = Cu or Ni, Ln = Ce−Yb) derived from the compartmental Schiff base ligand, H2L, obtained on condensation of 3-ethoxysalicylaldehyde with trans-1,2-diaminocyclohexane, are described. Single crystal X-ray structures of eight CuIILnIII compounds (Ln = Ce (1), Pr (2), Nd (3), Sm (4), Tb (7), Ho (9), Er (10), and Yb (12)) and three NiIILnIII (Ln = Ce (13), Sm (16), and Gd (18)) compounds have been determined. Considering the previously reported structure of the CuIIGdIII (6) compound (Eur. J. Inorg. Chem. 2005, 1500), a total of twelve structures are discussed/compared in this study. Four types of composition are observed in the CuIILnIII complexes: [CuIILLnIII (NO3)3(H2O)] (1−3: Ln = Ce−Nd), [CuIILSmIII(NO3)3]·CH3COCH3 (4), [CuII(H2O)LLnIII(NO3)3] (5: Ln = Eu; 6: Ln = Gd), and [CuIILLnIII(NO3)3] (4A: Ln = Sm; 7−12: Ln = Tb−Yb). On the other hand, the NiIILnIII complexes are characterized to have two types of composition: [NiIILLnIII(H2O)(NO3)3] (13−15: Ln = Ce−Nd) and [NiIILLnIII(NO3)3]·0.5CH3COCH3 (16−24: Ln = Sm−Yb). Among twelve X-ray structures, seven belong to three different isomorphous sets (CuIICeIII (1), CuIIPrIII (2), CuIINdIII (3), and NiIICeIII (13); CuIITbIII (7), CuIIHoIII (9), CuIIErIII (10), and CuIIYbIII (12); NiIISmIII (16) and NiIIGdIII (18)), whereas space group/unit cell parameters of two others (CuIISmIII (4) and CuIIGdIII (6)) are of different types. The lanthanide(III) centers in CuIICeIII (1), CuIIPrIII (2), CuIINdIII (3), and NiIICeIII (13) complexes are eleven-coordinated, while the lanthanide(III) centers in other compounds are ten-coordinated. As evidenced from the dihedral angle (δ) between the CuO(phenoxo)2 and LnO(phenoxo)2 planes, variation in the extent of planarity of the bridging moiety in the CuIILnIII compounds takes place; the ranges of δ values are 0.8−6.2° in the 4f1−7 analogues and 17.6−19.1° in the 4f8−13 analogues. The CuIIGdIII (6) compound exhibits ferromagnetic interaction (Eur. J. Inorg. Chem. 2005, 1500). The nature of the magnetic exchange interaction in the CuIILnIII complexes has been understood by utilizing the empirical approach; the NiIILnIII complexes have been used as references. The metal centers in the EuIII complex are uncorrelated, while other 4f1−6 analogues (CeIII, PrIII, NdIII, and SmIII) exhibit antiferromagnetic interaction. Among the higher analogues (4f7−13), only YbIII exhibits antiferromagnetic interaction, while interaction in other analogues (GdIII, TbIII, DyIII, HoIII, ErIII, and TmIII) is ferromagnetic. An important aspect of the present study is the measurement of the magnetic susceptibility of the unblocked samples as well as on blocking the samples with grease to avoid powder reorientation, if any. Comparison of the two sets of data reveals significant difference in some cases.
Localized Atmospheric Corrosion of Magnesium-Aluminum Alloys Produced by Semisolid Casting: A 2D and 3D Investigation (2020)

The localized corrosion of the two magnesium-aluminum alloys AM50 and AZ91 produced by a semisolid casting method was investigated under atmospheric corrosion conditions, in the presence of NaCl. Gravimetry confirmed the beneficial effect from ambient levels of carbon dioxide (CO2) in suppressing corrosion through the formation of magnesium hydroxy carbonates. Both 2D and 3D characterization revealed that ambient CO2 has a strong influence on the morphology and rate of localized corrosion. In CO2-free atmosphere, the alloys suffered localized corrosion resulting in clustered and interconnected cavities that extended deep into the material. In contrast, corrosion in the presence of ambient levels of CO2 (400 ppm) resulted in evenly distributed shallow corrosion sites. The results indicate that CO2 neutralizes the cathodic areas resulting in diminished cathodic activity and inhibiting NaCl(aq) droplet coalescence.
Smooth Karhunen-Loeve decomposition to analysis of randomly vibrating systems (2009)

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Online Fast Adaptation and Knowledge Accumulation: a New Approach to Continual Learning (2020)

Continual learning studies agents that learn from streams of tasks without forgetting previous ones while adapting to new ones. Two recent continual-learning scenarios have opened new avenues of research. In meta-continual learning, the model is pre-trained to minimize catastrophic forgetting of previous tasks. In continual-meta learning, the aim is to train agents for faster remembering of previous tasks through adaptation. In their original formulations, both methods have limitations. We stand on their shoulders to propose a more general scenario, OSAKA, where an agent must quickly solve new (out-of-distribution) tasks, while also requiring fast remembering. We show that current continual learning, meta-learning, meta-continual learning, and continual-meta learning techniques fail in this new scenario. We propose Continual-MAML, an online extension of the popular MAML algorithm as a strong baseline for this scenario. We empirically show that Continual-MAML is better suited to the new scenario than the aforementioned methodologies, as well as standard continual learning and meta-learning approaches.
A dual emission mechanism in Sgr A*/L' ? (2005)

We have collected in 2004 adaptive optics corrected L' images of the Galactic Center region with NAOS-CONICA at VLT. A strong variability was observed as well as a correlation between the photocenter positions and fluxes of the L'-band counterpart of Sgr A*. It is interpreted as the combined emission of a point-like flaring source at the position of Sgr A*/IR itself and an extended dust structure, 75 mas south west of Sgr A*/IR, which we name Sgr A*-f. We examine the different possible mechanisms to explain this dual Sgr A* L' emission and conclude it is likely a flaring emission associated to energetic events in the close environment of the black hole plus a quiescent emission resulting from the collision of Sgr A*-f by a jet from Sgr A*.
Bilayer in Small Bicelles Revealed by Lipid−Protein Interactions Using NMR Spectroscopy (2008)

Intermolecular nuclear Overhauser effects (NOEs) between the integral outer membrane protein OmpX from Escherichia coli and small bicelles of dihexanoyl phosphatidylcholine (DHPC) and dimyristoyl phosphatidylcholine (DMPC) give insights into protein-lipid interactions. Intermolecular NOEs between hydrophobic tails of lipid and protein in the bicelles cover the surface area of OmpX forming a continuous cylindric jacket of approximately 2.7 nm in height. These NOEs originate only from DMPC molecules, and no NOEs from DHPC are observed. Further, these NOEs are mainly from methylene groups of the hydrophobic tails of DMPC, and only a handful of NOEs arise from methyl groups of the hydrophobic tails. The observed contacts indicate that the hydrophobic tails of DMPC are oriented parallel to the surface of OmpX and thus DMPC molecules form a bilayer in the vicinity of the protein. Thus, a bilayer exists in the small bicelles not only in the absence of but also in the presence of a membrane protein. In addition, the number of NOEs between the polar head groups of lipid molecules and protein is increased in the bicelles compared with those in micelles. This observation may be due to the closely packed head groups of the bilayer. Moreover, irregularity of hydrophobic interactions in the middle of the bilayer environment was observed. This observation together with the interactions between polar head groups and proteins gives a possible rationale for structural and functional differences of membrane proteins solubilized in micelles and in bilayer systems and hints at structural differences between protein-free and protein-loaded bilayers.
Getting what one deserves (2010)

Men and women of our century tend to endow the people of ancient Athens with moral concerns almost identical with our own, imposing qualities we like best in ourselves upon Greeks unable to resist.Anne Pippin Burnett
Kinetic Modelling of Enzyme Catalyzed Biotransformation Involving Activations and Inhibitions (2017)

To achieve transition from lab scale enzyme studies to industrial applications, understanding of enzyme kinetics plays a critical role. The widely applied Michaelis Menten equation of the single substrate kinetics, sequential and double replacement mechanism of bisubstrate reaction and the relevant kinetics, inhibition and activation of enzyme are all integral parts of this discussion. In this chapter, we have discussed different types of inhibition and kinetic modelling. Systematic approach to generate data and its interpretation as well as designing of inhibitors is also explained.
Systemic sclerosis sera affect fibrillin-1 deposition by dermal blood microvascular endothelial cells: therapeutic implications of cyclophosphamide (2013)

Because of the critical role of fibrillin-1 in sequestering the latent form of TGF-β in the extracellular matrix, its decreased deposition by B-MVECs challenged with SSc sera might contribute to dermal fibrosis. In SSc, CYC treatment might limit fibrosis through the maintenance of physiologic fibrillin-1 synthesis and deposition by B-MVECs.