gebhart/patrepeval huggingface dataset:
A Human CD68 Promoter-Driven Inducible Cre-Recombinase Mouse Line Allows Specific Targeting of Tissue Resident Macrophages (2022)

Current genetic tools designed to target macrophages <i>in vivo</i> often target cells from all myeloid lineages. Therefore, we sought to generate a novel transgenic mouse which has a tamoxifen inducible Cre-recombinase under the control of the human CD68 promoter (hCD68-CreERT2). To test the efficiency and specificity of the of Cre-recombinase activity we crossed the hCD68-CreERT2 mice with a loxP-flanked STOP cassette red fluorescent protein variant (tdTomato) mouse. We established that orally dosing mice with 2 mg of tamoxifen for 5 consecutive days followed by a 5-day induction period resulted in robust expression of tdTomato in CD11b<sup>+</sup> F4/80<sup>+</sup> tissue resident macrophages. Using this induction protocol, we demonstrated tdTomato expression within peritoneal, liver and spleen macrophages and blood Ly6C<sup>low</sup> monocytes. Importantly there was limited or no inducible tdTomato expression within other myeloid cells (neutrophils, monocytes, dendritic cells and eosinophils), T cells (CD4<sup>+</sup> and CD8<sup>+</sup>) and B cells (CD19<sup>+</sup>). We also demonstrated that the level of tdTomato expression can be used as a marker to identify different populations of peritoneal and liver macrophages. We next assessed the longevity of tdTomato expression in peritoneal macrophages, liver and splenic macrophages and demonstrated high levels of tdTomato expression as long as 6 weeks after the last tamoxifen dose. Importantly, hCD68-CreERT2 expression is more restricted than that of LysM-Cre which has significant expression in major myeloid cell types (monocytes and neutrophils). To demonstrate the utility of this novel macrophage-specific Cre driver line we demonstrated tdTomato expression in recruited CD11b<sup>+</sup>CD64<sup>+</sup>F4/80<sup>+</sup> monocyte-derived macrophages within the atherosclerotic lesions of AAV8-mPCSK9 treated mice, with limited expression in recruited neutrophils. In developing this new hCD68-CreERT2 mouse we have a tool that allows us to target tissue resident macrophages, with the advantage of not targeting other myeloid cells namely neutrophils and inflammatory monocytes.
[Next cardioversion or RF ablation in professional driver with recurrent typical atrial flutter and MAS syndromes]. (2009)

We describe a 42-year-old professional driver with hypertension, obesity and recurrent episodes of highly symptomatic typical atrial flutter. Despite chronic sotalol treatment, 1:1 AV conduction with RBBB-morphology was observed. After excluding of thrombus in the heart chambers, the 'urgent' and successful RF ablation was performed.
The influence of low-intensity laser therapy on bone healing. (2012)

Based on the results of the reviewed articles, low intensity laser therapy can accelerate bone healing in extraction sites, bone fracture defects and distraction osteogenesis, provided proper parameters were applied.
The effect of nano-size second phases on the tribological performance of TNTZ alloy (2019)

The tribological performance of Ti-29Nb-14Ta-4.5Zr (TNTZ) alloy reinforced by various nano-sized phases has been studied. The β-phase matrix was reinforced by the different nano-second phases (α', α, and ω) during solution treatment and quenching in different media followed by aging at 500 °C and 300 °C for 48 hr. According to the EBSD results, no significant substructure development occurred beneath the wear track and the improvement in the tribological performance of TNTZ alloy is only due to the presence of well distributed-hard nanoscale precipitations in the β matrix. The tribological performances of the alloy reinforced by nano-ω/α precipitations are better than the two others by at least five times. The best tribological performance was found for the TNTZ alloy reinforced by nano-ω precipitations which introduce this structure as a promising high potential candidate for biomedical applications due to its superior tribological properties in the metal-to-metal contact condition.
Supplementary Results and Figure Legends 1-2 from Decreased NKX3.1 Protein Expression in Focal Prostatic Atrophy, Prostatic Intraepithelial Neoplasia, and Adenocarcinoma: Association with Gleason Score and Chromosome 8p Deletion (2023)

Supplementary Results and Figure Legends 1-2 from Decreased NKX3.1 Protein Expression in Focal Prostatic Atrophy, Prostatic Intraepithelial Neoplasia, and Adenocarcinoma: Association with Gleason Score and Chromosome 8p Deletion
ENDOCYTOSIS OF SIMPLE PROTEINS BY RAT YOLK-SACS INCUBATED in vitro (1981)

Conference Abstract| April 01 1981 ENDOCYTOSIS OF SIMPLE PROTEINS BY RAT YOLK-SACS INCUBATED in vitro Teake Kooistra; Teake Kooistra 1Biochemistry Research Laboratory, University of Keele, Keele, Staffs., ST5 5BG, U.K. Search for other works by this author on: This Site PubMed Google Scholar Kenneth E. Williams Kenneth E. Williams 1Biochemistry Research Laboratory, University of Keele, Keele, Staffs., ST5 5BG, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1981) 9 (2): 259P. https://doi.org/10.1042/bst009259pe Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Teake Kooistra, Kenneth E. Williams; ENDOCYTOSIS OF SIMPLE PROTEINS BY RAT YOLK-SACS INCUBATED in vitro. Biochem Soc Trans 1 April 1981; 9 (2): 259P. doi: https://doi.org/10.1042/bst009259pe Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1981 Biochemical Society1981 Article PDF first page preview Close Modal You do not currently have access to this content.
Discriminative Word Alignment with a Function Word Reordering Model (2010)

We address the modeling, parameter estimation and search challenges that arise from the introduction of reordering models that capture non-local reordering in alignment modeling. In particular, we introduce several reordering models that utilize (pairs of) function words as contexts for alignment reordering. To address the parameter estimation challenge, we propose to estimate these reordering models from a relatively small amount of manuallyaligned corpora. To address the search challenge, we devise an iterative local search algorithm that stochastically explores reordering possibilities. By capturing non-local reordering phenomena, our proposed alignment model bears a closer resemblance to stateof-the-art translation model. Empirical results show significant improvements in alignment quality as well as in translation performance over baselines in a large-scale Chinese-English translation task. 1
Privacy in LTE networks (2016)

Ever since the public revelation of global surveillance and the exploits targeting the mobile communication backend, the general awareness of user privacy in telecommunication industry has increased. Misusing the technical features of mobile core network technology - specifically the Signalling System 7 (SS7) has disclosed numerous ways to locate the mobile users and intercept the voice calls or text messages. These events had led the mobile network operator to focus more on protecting the privacy of user meta-data and signaling communication.With relatively more security and privacy features, Diameter protocol - the successor of SS7 in Long Term Evolution (LTE) networks are believed to guarantee more protection to end-users. In this paper, we argue that the default considerations of Diameter are not sufficient enough to offer privacy to the mobile user, particularly when it comes to location tracking. We will discuss the possibilities of the persistence of location tracking attacks from SS7 to Diameter. We also recommend the mobile network operators to review their security mechanisms based on the countermeasures that we present. In short, this paper provides a comprehensive overview of Diameter protocol to claim -- Without the appropriate measures, the Diameter-based LTE networks are as vulnerable as SS7-based GSM networks at least in terms of location tracking.
Feasibility Study for the Design of a Simultaneous X/Ka/Ka-Radar Feed System (2022)

A feasibility study to design a complex X/Ka-band feed system that also incorporates a Ka-band Radar function is undertaken. An unconventional wide-band Ka-band polarizer design was needed due to the high-power nature of the application.
Color Image Demosaicking Using a 3-Stage Convolutional Neural Network Structure (2018)

Color demosaicking (CDM) is a critical first step for the acquisition of high-quality RGB images with single chip cameras. Conventional CDM approaches are mostly based on interpolation schemes and hand-crafted image priors, which result in unpleasant visual artifacts in some cases. Motivated by the special characteristics of inter-channel correlations (higher correlations for R/G and G/B channels than that for R/B), in this paper, a 3-stage convolutional neural network (CNN) structure for CDM is proposed. In the first stage, the G channel is reconstructed independently. Then, by using the reconstructed G channel as guidance, the R and B channels are recovered in the second stage. Finally, high-quality RGB color images are reconstructed in the third stage. The objective and visual quality evaluation results show that the proposed structure achieves noticeable quality improvements in comparison to the state-of-the-art approaches.
Ventilatory and carotid body chemoreceptor responses to purinergic P2X receptor antagonists in newborn rats (2010)

Adenosine triphosphate, acting through purinergic P2X receptors, has been shown to stimulate ventilation and increase carotid body chemoreceptor activity in adult rats. However, its role during postnatal development of the ventilatory response to hypoxia is yet unknown. Using whole body plethysmography, we measured ventilation in normoxia and in moderate hypoxia (12% fraction of inspired O₂, 20 min) before and after intraperitoneal injection of suramin (P2X₂ and P2X₃ receptor antagonist, 40 mg/kg) in 4-, 7-, 12-, and 21-day-old rats. Suramin reduced baseline breathing (∼20%) and the response to hypoxia (∼30%) in all rats, with a relatively constant effect across ages. We then tested the effect of the specific P2X₃ antagonist, A-317491 (150 mg/kg), in rats aged 4, 7, and 21 days. As with suramin, A-317491 reduced baseline ventilation (∼55%) and the hypoxic response (∼40%) at all ages studied. Single-unit carotid body chemoreceptor activity was recorded in vitro in 4-, 7-, and 21-day-old rats. Suramin (100 μM) and A-317491 (10 μM) significantly depressed the sinus nerve chemosensory discharge rate (∼80%) in normoxia (Po₂ ∼150 Torr) and hypoxia (Po₂ ∼60 Torr), and this decrease was constant across ages. We conclude that, in newborn rats, P2X purinergic receptors are involved in the regulation of breathing under basal and hypoxic condition, and P2X₃-containing receptors play a major role in carotid body function. However, these effects are not age dependent within the age range studied.
Limiting Self-Propagating Malware Based on Connection Failure Behavior (2015)

Self-propagating malware (e.g., an Internet worm) exploits security loopholes in software to infect servers and then use them to scan the Internet for more vulnerable servers. While the mechanisms of worm infection and their propagation models are well understood, defense against worms remains an open problem. One branch of defense research investigates the behavioral difference between worm-infected hosts and normal hosts to set them apart. One particular observation is that a worm-infected host, which scans the Internet with randomly selected addresses, has a much higher connection-failure rate than a normal host. Rate-limit algorithms have been proposed to control the spread of worms by traffic shaping based on connection failure rate. However, these rate-limit algorithms can work properly only if it is possible to measure failure rates of individual hosts efficiently and accurately. This paper points out a serious problem in the prior method and proposes a new solution based on a highly efficient double-bitmap data structure, which places only a small memory footprint on the routers, while providing good measurement of connection failure rates whose accuracy can be tuned by system parameters.
Implementation of active distributed RC anti-aliasing/smoothing filters (1982)

The design of an active distributed RC filter is described for use as an anti-aliasing/smoothing filter in a PCM channel bank filter. A new filter configuration (known as a Rauch filter) has been chosen which uses the op amp in inverting configuration with a zero common mode signal and thus results in improved high-frequency attenuation characteristics along with good power supply rejection. A conventional Sallen and Key configuration with distributed RC elements is also discussed.
PaGraph (2020)

Emerging graph neural networks (GNNs) have extended the successes of deep learning techniques against datasets like images and texts to more complex graph-structured data. By leveraging GPU accelerators, existing frameworks combine both mini-batch and sampling for effective and efficient model training on large graphs. However, this setup faces a scalability issue since loading rich vertices features from CPU to GPU through a limited bandwidth link usually dominates the training cycle. In this paper, we propose PaGraph, a system that supports general and efficient sampling-based GNN training on single-server with multi-GPU. PaGraph significantly reduces the data loading time by exploiting available GPU resources to keep frequently accessed graph data with a cache. It also embodies a lightweight yet effective caching policy that takes into account graph structural information and data access patterns of sampling-based GNN training simultaneously. Furthermore, to scale out on multiple GPUs, PaGraph develops a fast GNN-computation-aware partition algorithm to avoid cross-partition access during data parallel training and achieves better cache efficiency. Evaluations on two representative GNN models, GCN and GraphSAGE, show that PaGraph achieves up to 96.8% data loading time reductions and up to 4.8X performance speedup over the state-of-the-art baselines. Together with preprocessing optimization, PaGraph further delivers up to 16.0X end-to-end speedup.
A process-based life cycle sustainability assessment of the space-based solar power concept (2020)

For space-based solar power (SBSP) to be considered as a truly viable renewable energy technology, there should be a clear environmental benefit gained from its application. Additionally, given the scale of investment and engineering development, the price of energy must remain comparable to terrestrial-based generation systems for commercial feasibility. For this reason, a process-based life cycle sustainability assessment (LCSA) study was conducted to identify the life cycle environmental, economic and social impacts of the 1978 DOE/NASA Solar Power Satellite (SPS) Reference System. This was one of the first ever LCSA studies for space systems to be performed worldwide and was applied using a new LCSA tool for space missions developed at the University of Strathclyde. Taking a burden-based approach, the tool has been used to calculate environmental impacts across a wide range of different environmental impact categories and quantify costs over the system life cycle. The inclusion of social impacts adds additional depth to the analysis by showcasing the sociological impacts of the system on various stakeholder groups in line with the 2030 Agenda for Sustainable Development. The calculated life cycle impacts were then analysed further to identify potential hotspots through multi-criteria decision analysis (MCDA) and by measuring the results against annual global impacts (AGIs) and planetary boundaries (PBs). Life cycle CO2e emissions and costs were then compared to terrestrial energy generation systems in order to benchmark the relative performance of the technology as part of the conventional energy mix. The results suggest that whilst the DOE/NASA SPS Reference System can generally be described as a ‘green’ and ‘cost-effective’ system, several design improvements can and should be made to lessen its life cycle impacts. Therefore, it is proposed that the identified hotspots are used as a baseline for comparison or as mission drivers to continually improve future SPS designs.
Molecular Dynamics Insight into the Role of Water Molecules in Ionic Liquid Mixtures of 1-Butyl-3-methylimidazolium Iodide and Ethylammonium Nitrate (2022)

Imidazolium-based ionic liquids are well known for their versatility as solvents for various applications such as dye-sensitized solar cells, fuel cells, and lithium-ion batteries; however, their complex interactions continue to be investigated to further improve upon their design. Ionic liquids (ILs) are commonly mixed with co-solvents such as water, organic solvents, or other ionic liquids to tailor their physiochemical properties. To better predict these properties and fundamentally understand the molecular interactions within the electrolyte mixtures, molecular dynamics (MD) simulations are often employed. In this study, MD simulations are performed on ternary solutions containing ionic liquids of 1-butyl-3-methylimidazolium iodide ([BMIM][I]) and ethylammonium nitrate ([EA][NO<sub>3</sub>]) with increasing concentration of water. As previously reported, these ternary solutions displayed a wide temperature window of thermal stability and electrochemical conductivity. Utilizing MD simulations, the complex intermolecular interactions are identified, and the role of water as a co-solvent is disclosed to correlate with changes in their bulk properties. The MD results, including simulation box snapshots, radial distribution functions, and self-diffusion coefficients, reveal the formation of heterogeneous regimes with increasing water concentration, hydrogen bonding between iodide-water, iodide-[EA]<sup>+</sup>, and a change in IL ordering when in mixtures containing water. The simulations also display the formation of water aggregates and networks at high water concentrations, which can contribute to the thermal behavior of the respective mixtures. As the design of IL-based electrolytes grows in demand with increasing complexity, this work demonstrates the capability of MD simulations containing multiple constituents and their necessity in material development through identification of microscopic structure-property relationships.
Pembrolizumab plus docetaxel for patients with metastatic castration-resistant prostate cancer (mCRPC): Randomized, double-blind, phase 3 KEYNOTE-921 study. (2023)

19 Background: Docetaxel is a treatment option following disease progression on a next-generation hormonal agent (NHA) for patients with mCRPC, but there is an urgent need for more efficacious treatments. The randomized, double-blind, phase 3 KEYNOTE-921 study (NCT03834506) evaluated the efficacy and safety of pembrolizumab + docetaxel vs placebo + docetaxel for participants (pts) with mCRPC who had received prior NHA therapy. Methods: Eligible pts were ≥18 years old, had mCRPC that progressed on androgen deprivation therapy, had received 1 prior NHA, and had an ECOG performance status of 0 or 1. Pts were randomized 1:1 to receive 200 mg pembrolizumab Q3W or placebo for ≤35 cycles (~2 years) in combination with 75 mg/m 2 docetaxel Q3W for ≤10 cycles and 5 mg prednisone BID. The dual primary endpoints were radiographic progression-free survival (rPFS; tested at first interim analysis) per PCWG-modified RECIST 1.1 by blinded independent central review and overall survival (OS; tested at final analysis). The key secondary endpoint was time to initiation of the first subsequent anticancer therapy (TFST; at first interim analysis). Safety was one of the secondary endpoints. Results: Between May 30, 2019 and June 17, 2021, 1030 pts were randomized to receive pembrolizumab + docetaxel (n=515) or placebo + docetaxel (n=515). The median (range) time from randomization to data cutoff date of June 20, 2022 at final analysis was 22.7 mo (12.1−36.7). Baseline characteristics were generally balanced between arms; approximately half of pts in each arm had received prior abiraterone. Pts in the pembrolizumab + docetaxel arm received a median (range) of 12 (1–35) cycles of pembrolizumab and 9 (1–12) cycles of docetaxel; pts in the placebo + docetaxel arm received a median (range) of 12 (1–35) cycles of placebo and 9 (1–10) cycles of docetaxel. The dual primary endpoints of rPFS (median 8.6 mo with pembrolizumab + docetaxel vs 8.3 mo with placebo + docetaxel; HR 0.85, 95% CI 0.71−1.01; P=0.0335) and OS (median 19.6 mo vs 19.0 mo; HR 0.92, 95% CI 0.78−1.09; P=0.1677) were not met. Median TFST was 10.7 mo vs 10.4 mo, respectively (HR 0.86, 95% CI 0.74−1.01). Treatment-related AEs occurred in 94.6% (grade ≥3 in 43.2%) and 94.9% (grade ≥3 in 36.6%) of pts with pembrolizumab + docetaxel vs placebo + docetaxel. 2 treatment-related deaths with pembrolizumab + docetaxel and 7 with placebo + docetaxel were reported. Immune-mediated AEs and infusion reactions occurred in 23.3% (grade ≥3 in 6.2%) and 12.3% (grade ≥3 in 1.2%) of pts with pembrolizumab + docetaxel vs placebo + docetaxel, most commonly pneumonitis (7.0% vs 3.1%) and hypothyroidism (6.4% vs 3.3%). Conclusions: The addition of pembrolizumab to docetaxel did not significantly improve rPFS or OS for pts with mCRPC and did not result in a notable increase in treatment-related AEs. Clinical trial information: NCT03834506 .
Effects of monolayer and bilayer silica films on Fe-Phthalocyanine adsorption properties (2023)

We explore the adsorption properties of Fe-Phthalocyanine (FePc) molecule at various configurations of silica films supported by Ru(0001) and report on the geometric, electronic and magnetic features of the energetically preferred structures to fully understand the influence of the silica films on the adsorption properties of the FePc molecule. The investigation is carried out with the use of density of functional theory calculations and the self-consistent inclusion of van der Waals interaction. In addition, Oxygen atoms are added to govern the atomic structure of the silica overlayers on the surface. Our results show that both FePc/silica thin film systems exhibit both physisorption and chemisorption simultaneously. In addition, the FePc molecule on each substrate undergoes a symmetry reduction driven by mismatch with the substrates' symmetry as well as the breakup of the degenerate orbitals of Fe.
Pilot Study of Minocycline in Relapsing-Remitting Multiple Sclerosis (2008)

Background: Current multiple sclerosis (MS) treatment is only partially effective and not all patients respond well. The goal in this study was to evaluate minocycline for its safety, tolerability, and MRI impact as a potential therapy over 36 months after a three month run-in in ten relapsing-remitting (RR) MS patients. Methods: Clinical assessments were at three month intervals until six months, then at six month intervals. Three Tesla MRI was performed monthly during the run-in and first six months of treatment, then at 12, 24, and 36 months. Results: Treatment was safe and well tolerated. Annualized relapse rate was 1.2 during the run-in and 0.25 during treatment. The proportion of active scans was lower during the first six months of treatment (5.6%, p&lt;0.001) and during the extension (8.7%, p= 0.002) than during the run-in (47.5%). Consistent with these outcomes, mean T2 lesion volume remained stable over three years and percent brain volume change was reduced during year three (-0.37%) of minocycline treatment. Conclusions: This trial is limited by small sample and no control group but suggests that minocycline is safe and potentially beneficial in RRMS . This supports further investigation of its efficacy.