gebhart/patrepeval huggingface dataset:
Phosphorus Trioxide as a Tetradentate Ligand. II. Borane Complexes (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphorus Trioxide as a Tetradentate Ligand. II. Borane ComplexesJean G. Riess and John R. Van WazerCite this: J. Am. Chem. Soc. 1967, 89, 4, 851–856Publication Date (Print):February 1, 1967Publication History Published online1 May 2002Published inissue 1 February 1967https://pubs.acs.org/doi/10.1021/ja00980a021https://doi.org/10.1021/ja00980a021research-articleACS PublicationsRequest reuse permissionsArticle Views74Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Long-Term Blockade of Nociceptive Nav1.7 Channels Is Analgesic in Rat Models of Knee Arthritis (2022)

The voltage gated sodium channels (Nav) 1.7, 1.8, and 1.9 are primarily located on nociceptors where they are involved in signalling neuropathic pain. This study examined the effect of Nav1.7 blockade on joint pain using either the small molecule inhibitor PF05089771 or an antibody directed towards the intracellular domain of the ion channel. Male Wistar rats were assigned to one of three experimental groups consisting of either intra-articular injection of 3 mg sodium monoiodoacetate (MIA—joint degeneration group), intra-articular injection of 100 μg lysophosphatidic acid (LPA—joint neuropathy group), or transection of the medial meniscus (MMT—posttraumatic osteoarthritis group). G-ratio calculations were performed to determine potential demyelination and immunohistochemistry was used to measure Nav1.7 expression on joint afferent cell bodies. Pain behaviour was evaluated over 3 h by von Frey hair algesiometry and hindlimb weight bearing before and after local administration of PF05089771 (0.1 mg/50 µL). Chronic pain behaviour was assessed over 28 days following peripheral treatment with a Nav1.7 antibody (Ab) in conjunction with the transmembrane carrier peptide Pep1. Demyelination and increased Nav1.7 channel expression were observed in MIA and LPA rats, but not with MMT. Acute secondary allodynia was diminished by PF05089771 while a single injection of Nav1.7 Ab-Pep1 reduced pain up to 28 days. This analgesia only occurred in MIA and LPA animals. Hindlimb incapacitance was not affected by any treatment. These data indicate that joint pain associated with neural demyelination can be alleviated somewhat by Nav1.7 channel blockade. Biologics that inactivate Nav1.7 channels have the potential to reduce arthritis pain over a protracted period of time.
Solubility of plutonium nitrate in uranyl nitrate hexahydrate melt (2008)

At a weight fraction below 20%, Pu(IV) nitrate is isomorphically dissolved and homogeneously distributed in the uranyl nitrate hexahydrate phase, the solubility being independent of the HNO3 concentration in the mixed U-Pu melt up to the acid concentration of 7 M. In dissolving solid Pu(IV) nitrate in 1–6 M HNO3, Pu(IV) disproportionates to form Pu(III) and Pu(VI). With increasing HNO3 concentration to above 10 M, Pu(IV) passes into solution as Pu(NO3) 6 2− , and no disproportionation is observed.
Construction and Multiple Exterior Surface Functionalization of Giant Molecular Cages (2014)

Abstract By a one‐pot reaction strategy and a stepwise fragment‐coupling approach, three types of giant cage molecules with a triangular prism shape and an approximate cavity volume of 930 Å 3 were synthesized. Through efficient aromatic nucleophilic substitution reactions of chlorotriazine with functionalized amines or aliphatic substitution reactions of the linking imino moieties with allyl bromide, the giant cages were successfully functionalized on the surface with multiple hydroxy, 2‐pyridyl, or allyl groups. As evidenced by variable‐temperature 1 H NMR spectroscopy, the D 3 h ‐ and C 3 v ‐symmetric cage molecules underwent very slow conformational changes or deformation in solution because of their giant size and their flexible building units. Their giant cavities, different electronic interiors, and facile multiple exterior surface functionalization could render the molecular cages powerful three‐dimensional macrocyclic hosts that might find wide applications in supramolecular science.
ChemInform Abstract: EVIDENCE FOR DIFFERENT ADDITION MECHANISMS IN THE BROMOCHLORINATION OF 3‐TERT.‐BUTYLCYCLOHEXENE WITH BROMINE CHLORIDE AND WITH MONOPYRIDINEBROMINE (I) CHLORIDE (1974)

Abstract 3‐tert.‐Butyl‐cyclohexen (I) wird der Bromchlorierung unterworfen.
In Vivo Delivery of Therapeutic Molecules by Transplantation of Genome-Edited Induced Pluripotent Stem Cells (2023)

Human induced pluripotent stem cells (iPSCs) have already been used in transplantation therapies. Currently, cells from healthy people are transplanted into patients with diseases. With the rapid evolution of genome editing technology, genetic modification could be applied to enhance the therapeutic effects of iPSCs, such as the introduction of secreted molecules to make the cells a drug delivery system. Here, we addressed this possibility by utilizing a Fabry disease mouse model, as a proof of concept. Fabry disease is caused by the lack of α-galactosidase A (GLA). We previously developed an immunotolerant therapeutic molecule, modified α-<i>N</i>-acetylgalactosaminidase (mNAGA). We confirmed that secreted mNAGA from genome-edited iPSCs compensated for the GLA activity in GLA-deficient cells using an <i>in vitro</i> co-culture system. Moreover, iPSCs transplanted into Fabry model mice secreted mNAGA and supplied GLA activity to the liver. This study demonstrates the great potential of genome-edited iPSCs secreting therapeutic molecules.
Functional Magnetic Resonance Imaging of Motor Cortex: Hemispheric Asymmetry and Handedness (1993)

A hemispheric asymmetry in the functional activation of the human motor cortex during contralateral (C) and ipsilateral (I) finger movements, especially in right-handed subjects, was documented with nuclear magnetic resonance imaging at high field strength (4 tesla). Whereas the right motor cortex was activated mostly during contralateral finger movements in both right-handed (C/I mean area of activation = 36.8) and left-handed (C/I = 29.9) subjects, the left motor cortex was activated substantially during ipsilateral movements in left-handed subjects (C/I = 5.4) and even more so in right-handed subjects (C/I = 1.3).
LESSONS LEARNED FROM IMPLEMENTATION OF MONITORED NATURAL ATTENUATION FOR AN AEROBIC TRICHLOROETHENE PLUME AT THE IDAHO NATIONAL ENGINEERING AND ENVIRONMENTAL LABORATORY (2005)

The Test Area North (TAN) Facility of the Idaho National Engineering and Environmental Laboratory (INEEL) is the site of a 3-km-long trichloroethene (TCE) plume resulting from past waste injections into the deep fractured basalt aquifer. An in-depth natural attenuation field evaluation showed that aerobic TCE degradation was occurring with a half-life of 9 to 21 years (1) in the plume’s distal zone. Given the lack of precedent for the significance of this degradation mechanism under intrinsic conditions, activity-dependent enzyme probe assays were performed on TAN field samples. Results showed that microbial enzymes known to cometabolize TCE are present and active in the TAN aquifer, both inside and outside of the TCE plume. In addition, a multi-level sampling program was implemented to investigate the three-dimensional contaminant distribution in the distal zone. These results confirmed the original conceptual model for the distal zone by demonstrating that no previously uncharacterized zones of TCE flux exist in the distal zone.
Predictive value of absolute CD4 cell count for disease progression in untreated HIV-1-infected children (2006)

This study suggests it may be appropriate to extend CD4 cell count criteria for initiating antiretroviral therapy in HIV-1-infected adults to children as young as 4 or 5 years. Monitoring by CD4 cell count in younger children is problematical because age is a highly influential variable.
The Number of Structurally Isomeric Hydrocarbons of the Ethylene Series1 (1933)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Number of Structurally Isomeric Hydrocarbons of the Ethylene Series1Henry R. Henze and Charles M. BlairCite this: J. Am. Chem. Soc. 1933, 55, 2, 680–686Publication Date (Print):February 1, 1933Publication History Published online1 May 2002Published inissue 1 February 1933https://pubs.acs.org/doi/10.1021/ja01329a033https://doi.org/10.1021/ja01329a033research-articleACS PublicationsRequest reuse permissionsArticle Views63Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
TFTR Plasma Feedback Systems (1985)

The Tokamak Fusion Test Reactor (TFTR) employs feedback control systems for four plasma parameters, i.e. for plasma current, for plasma major radius, for plasma vertical position, and for plasma density.The plasma current is controlled by adjusting the rate of change of current in the Ohmic Heating (OH) coil system. Plasma current is continuously sensed by a Rogowski coil and its associated electronics; the error between it and a preprogrammed reference plasma current history is operated upon by a “proportional-plus-integral-plus-derivative” (PID) control algorithm and combined with various feedforward terms, to generate compensating commands to the phase-controlled thyristor rectifiers which drive current through the OH coils.The plasma position is controlled by adjusting the currents in Equilibrium Field (EF) and Horizontal Field (HF) coil systems, which respectively determine the vertical and radial external magnetic fields producing J X B forces on the plasma current. The plasma major radius position and vertical position, sensed by “Btheta” and “Brho” magnetic flux pickup coils with their associated electronics, are controlled toward preprogrammed reference histories by allowing PID and feedforward control algorithms to generate commands to the EF and HF coil power supplies.Plasma density is controlled by adjusting the amount of gas injected into the vacuum vessel. Time-varying gains are used to combine line-averaged plasma density measurements from a microwave interferometer plasma diagnostic system with vacuum vessel pressure measurements from ion gauges, with various other measurements, and with preprogrammed reference histories, to determine commands to piezoelectric gas injection valves.
Feasibility of real-time MRI of the actively moving wrist at 0.55 Tesla (2023)

In this work we show results from a first-in-human study utilizing a high-performance 0.55T system and balanced SSFP (bSSFP) real-time MRI acquisition to assess tissues of the actively moving wrist&amp;rsquo;s uninterrupted radial-ulnar deviation and clenched fist maneuvers. We show that at 0.55T, bSSFP is less sensitive to off-resonance and banding artifacts that frequently obscure critical wrist structures. We show that the high temporal resolution of 25 ms per frame at high-performance 0.55T enables improved characterization of wrist joint motion. These benefits could make it a promising technology to evaluate dynamic wrist instability.
Disposition of debrisoquine in Caucasians with different CYP2D6-genotypes including those with multiple genes (1999)

Debrisoquine is a major prototypic in-vivo probe used to assess polymorphic CYP2D6 activity in humans, based on the 0-8 h urinary excretion of unchanged drug and its 4-hydroxy metabolite (the so-called metabolic ratio). The primary purpose of the study was to investigate further the relationship between genotype and phenotype by determining the overall disposition characteristics of the drug in selected groups of healthy Swedish Caucasian individuals. Debrisoquine (20 mg) was orally administered to five poor metabolizers with no functional CYP2D6 gene, five heterozygous extensive metabolizers, five homozygous extensive metabolizers, five ultrarapid metabolizers with duplicated/triplicated CYP2D6*2 genes and one individual with 13 copies of CYP2D6*2. Peak plasma levels of debrisoquine and 4-hydroxydebrisoquine were attained within 2-4 h and then declined in a multi-exponential fashion over 96 h. However, the post 8-h period of the elimination process was characterized by irregular fluctuations that prevented formal pharmacokinetic analysis. Nevertheless, marked differences were apparent in the compounds' plasma level-time profiles between the CYP2D6 genotypes. For example, in the case of debrisoquine, the mean ratio of the AUC(0-8) values was 22:22:7:6:1, corresponding to 0, 1, 2, 3/4 and 13 genes and, for 4-hydroxydebrisoquine, the respective values were 1:7:19:28:17. The 0-96 h urinary recovery of debrisoquine differed 100-fold between the genotypes, being essentially complete in poor metabolizers and zero in the individual with 13 CYP2D6*2 genes. 4-hydroxydebrisoquine excretion increased according to the number of functional CYP2D6 genes. A highly significant correlation (r(s) = 0.95, P < 0.001) was observed between the plasma AUC(0-8) ratio for debrisoquine to 4-hydroxydebrisoquine and the 0-8 h urinary metabolic ratio. This study demonstrates that the number of functional CYP2D6 alleles is critically important in the plasma concentration-time curves of debrisoquine and its CYP2D6-mediated 4-hydroxy metabolite. Concentration-related pharmacologic effects would be expected to be similarly affected by gene dosage and it is likely that the same situation also applies to other drugs whose elimination is importantly determined by this enzyme; for example, many antidepressants and neuroleptics, antiarrhythmic agents, beta-adrenoceptor antagonists and opiates.
Arthroscopic Management of Tibial Plateau Fractures (2007)

ABSTRACT
Arthroscopic reduction with internal fixation has long been recognized as a treatment option for select tibial plateau fractures. Benefits of direct visualization of chondral surface reduction, diagnosis and treatment of associated intraarticular soft tissue injuries, joint lavage, decreased soft tissue dissection, and improved rehabilitation have been described in the literature. A review of surgical techniques and instrumentation for various fracture types is presented.
Multi-parametric MRI of the prostate: Factors predicting extracapsular extension at the time of radical prostatectomy (2016)

While mpMRI is an accurate preoperative assessment tool for the detection of ECE, its overall sensitivity is poor, likely related to the low detection rate of standard protocol MRI for microscopic extraprostatic disease. The additional mpMRI findings described may also be considered in surgical margin planning prior to radical prostatectomy.
INFLUENCE OF THE POOL SIZE OF THE XANTHOPHYLL CYCLE ON THE EFFECTS OF LIGHT STRESS IN A DIATOM: COMPETITION BETWEEN PHOTOPROTECI'ION AND PHOTOINHIBITION (1994)

Abstract In a study of the relationship between nonphotochemical quenching of fluorescence and the xanthophyll cycle, we show that the diatom Phaeodactylum tricornutum exhibits several interesting characteristics. This xanthophyll cycle consists of only one reversible epoxidating/deepoxidating step (diadinoxanthiddiatoxanthin). Diadinoxan‐thin, which increases from 8 to 17 molecules/100 chlorophyll a (Chl a ) during the ageing of the culture, was present as two separate pools, with a portion (of about 5 molecules/100 Chl a) which was never deepoxidated. Under a defined irradiance, the time necessary to abolish net photosynthesis increases with the pool size of diadinoxanthin available for deepoxidation. A close correlation is found between nonphotochemical quenching and the relative ratio of diatoxanthin until the photosytem II center is inactivated. The photoprotective effect of diadinoxanthin deepoxidation is limited to the phase during which quenching of the minimum fluorescence (F 0 ) develops.
Photoluminescence of large-sized InAs/GaAs quantum dots under hydrostatic pressure (2005)

The photoluminescence of self-assembled InAs/GaAs quantum dots, which are 7.3nm in height and 78nm in base size, was investigated at 15K under hydrostatic pressures up to 9GPa. The emissions from both the ground and the first excited states in large InAs dots were observed. The pressure coefficients of the two emissions are 69 and 72 meV/GPa respectively, which are lower than those of small InAs/GaAs dots. The analysis based on a nonlinear elasticity theory reveals that the small pressure coefficients mainly result from the changes of the misfit strain and the elastic constants with pressure. The pressure experiments suggest that the excited state emissions originate from the optical transitions between the first excited electron states and the first excited hole states.
Synthesis and characterization of chiral conjugated polymers for optical waveguides (2002)

In the pursuit of new photonic devices, the unique waveguide properties of chiral films made from single-handed helical molecules are under investigation. The synthesis of polymers with a hierarchical structure is the first step. In this paper we present results on the synthesis and characterization of poly(p-phenylenes) (PPPs) and polythiophenes possessing amine and amide chiral side-chains. A regioirregular PPP possessing one chiral side group per repeat unit was prepared. Regioregular PPPs possessing two chiral side groups per repeat unit were also synthesized; however, lower molecular weights were achieved due to steric constraints. The PPPs exhibited total optical rotation that was a function of the concentration of the chiral side group, with 35- per chiral group or 70- per repeat unit. A regioirregular polythiophene was prepared using oxidative polymerization. A molecular structure that leads to helical polymer chains that undergo supramolecular packing in spin-cast films is the goal.
Three-dimensional space-charge measurement in a dielectric using the acoustic lens and PWP method (1999)

A three-dimensional space-charge measurement system using the acoustic lens and PWP method has been developed. The resolutions on the x-y plane and in the z direction of this system are about and m respectively. It takes about 3 s for each sample position and 130 min for positions on the x-y plane for a mm specimen. This speed is much higher than that of the three-dimensional space-charge measurement system using the PEA method. Although the resolutions of this system on the x-y plane and along the z direction are not high, the three-dimensional charge profile of an electron-beam-irradiated PMMA specimen is successfully constructed.
Visualization of Amyloid Arthropathy in Light-Chain Systemic Amyloidosis on F-18 FDG PET/CT Scan (2010)

We report a case of 63-year-old man with symmetrical joint swelling of the interphalangeal and metacarpal joints, associated with isolated hypogammaglobulinemia. Accessory glands biopsy revealed the presence of amyloidal deposits. PET/CT showed increased F-18 FDG activity in thickened soft tissues corresponding to amyloid arthropathy. Like multiple myeloma, PET/CT could be an interesting imaging in light-chain amyloidosis.
Relation Between Mild Renal Dysfunction and Outcomes After Coronary Artery Bypass Grafting (2005)

Mild renal dysfunction is an important predictor of outcome in terms of in-hospital mortality, morbidity, and midterm survival in patients undergoing CABG.
Cryptococcus neoformans Phosphoinositide-Dependent Kinase 1 (PDK1) Ortholog Is Required for Stress Tolerance and Survival in Murine Phagocytes (2012)

Cryptococcus neoformans PKH2-01 and PKH2-02 are orthologous to mammalian PDK1 kinase genes. Although orthologs of these kinases have been extensively studied in S. cerevisiae, little is known about their function in pathogenic fungi. In this study, we show that PKH2-02 but not PKH2-01 is required for C. neoformans to tolerate cell wall, oxidative, nitrosative, and antifungal drug stress. Deletion of PKH2-02 leads to decreased basal levels of Pkc1 activity and, consequently, reduced activation of the cell wall integrity mitogen-activated protein kinase (MAPK) pathway in response to cell wall, oxidative, and nitrosative stress. PKH2-02 function also is required for tolerance of fluconazole and amphotericin B, two important drugs for the treatment of cryptococcosis. Furthermore, OSU-03012, an inhibitor of human PDK1, is synergistic and fungicidal in combination with fluconazole. Using a Galleria mellonella model of low-temperature cryptococcosis, we found that PKH2-02 is also required for virulence in a temperature-independent manner. Consistent with the hypersensitivity of the pkh2-02Δ mutant to oxidative and nitrosative stress, this mutant shows decreased survival in murine phagocytes compared to that of wild-type (WT) cells. In addition, we show that deletion of PKH2-02 affects the interaction between C. neoformans and phagocytes by decreasing its ability to suppress production of tumor necrosis factor alpha (TNF-α) and reactive oxygen species. Taken together, our studies demonstrate that Pkh2-02-mediated signaling in C. neoformans is crucial for stress tolerance, host-pathogen interactions, and both temperature-dependent and -independent virulence.
Efficacy of Upper Extremity Robotic Therapy in Subacute Poststroke Hemiplegia (2016)

URL: http://www.umin.ac.jp/. Unique identifier: UMIN000001619.
The effect of hydrogen-radical annealing for SiO/sub 2/ passivation (2002)

The reduction of recombination velocity is important in obtaining high-efficiency solar cells, and SiO/sub 2/ passivation and hydrogen post-annealing are therefore widely used as surface passivation techniques. This investigation of hydrogen-radical post-annealing using the microwave hydrogen afterglow method shows that this procedure increases the effective lifetime of silicon wafers with SiO/sub 2/ passivation layers with a very short annealing time to a degree greater than does 3% H/sub 2/ forming gas annealing.
Geo-China 2016 (2016)

Selected papers from the Fourth Geo-China International Conference, held in Shandong, China, July 25–27, 2016. Sponsored by Shandong University, Shandong Department of Transportation, University of Oklahoma, Chinese National Science Foundation, and the Geo-Institute of ASCE.