gebhart/patrepeval huggingface dataset:
FOR CANCELLING CO-CHANNEL INTERFERENCE AND IMAGE-BAND INTERFERENCE (2009)

We propose an architecture which reduce the circuit size to concurrently cancel co-channel interference and image- band interference. We adopt analogue Hilbert transformers to cancel image-band interference and adaptive array antennas to cancel co-channel interference. Furthermore, we can miniaturize the receiver by mixing all signals at the IF stage. We also show performance of the proposed system by computer simulation. As a result, image-band interference caused by some imperfection of Hilbert transformer can be completely canceled. Moreover, co-channel interference can be simultaneously canceled. I. INTRODUCTION Various radio transmission systems have recently been com- mercialized. Basically, each of these systems uses different frequency band. Hence, frequency bands for new radio systems become limited. Therefore, it is necessary to increase the frequency utilization efficiency of radio systems as much as possible. For this purpose, mobile transmission systems adopt cellular concepts. In cellular systems, a signal transmitted from a cell can be propagated to another cell. If the two cells use the same frequency, the transmitted signal turn out to interfere with signals from the other cell and transmission performance is impaired. Moreover, when several radio systems are allowed to share the same frequency band such as ISM (Industrial,
Brentuximab Vedotin: A CD30‐Directed Antibody‐Cytotoxic Drug Conjugate (2013)

Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL), which is a subtype of non-Hodgkin lymphoma, are relatively uncommon lymphoproliferative types of cancer. These malignancies are highly curable with initial treatment. Nonetheless, some patients are refractory to or relapse after first- and second-line therapies, and outcomes for these patients are less promising. Brentuximab vedotin is a CD30-directed antibody-cytotoxic drug conjugate that has demonstrated efficacy in response rates (objective response rates and complete response) when given to patients with refractory or relapsed HL and sALCL. Although not compared directly in clinical trials, the response rates with brentuximab vedotin are higher than those of several current treatments for refractory or relapsed HL and sALCL. Adverse effects associated with brentuximab vedotin are considered manageable. Nonetheless, several serious adverse effects (e.g., neutropenia, peripheral sensory neuropathy, tumor lysis syndrome, Stevens-Johnson syndrome, and progressive multifocal leukoencephalopathy, resulting in death) have been reported with its use. Despite a lack of survival and patient reported outcome data, the United States Food and Drug Administration (FDA) granted accelerated approval to brentuximab vedotin for the treatment of HL after failure of autologous stem cell transplantation or at least two combination chemotherapy regimens, and for sALCL after failure of at least one combination chemotherapy regimen. With this approval, brentuximab vedotin is the first FDA-approved agent for the treatment of HL in over three decades and the first agent specifically indicated to treat sALCL. Results of ongoing prospective trials should determine if brentuximab vedotin has a survival benefit when compared directly with standard treatment and if brentuximab vedotin is safe and efficacious when given earlier in the disease process, or when used with other chemotherapy for the treatment of HL and sALCL or other CD30-positive malignancies.
Systemic administration of E-selectin-directed dexamethasone liposomes attenuates pulmonary inflammation in a mouse model of ventilator-induced lung injury (2009)

Mechanical ventilation (MV) may evoke damage to healthy lungs leading to ventilator-induced lung injury (VILI). We hypothesized that downregulation of pulmonary inflammation may attenuate VILI. The present study investigated whether lung inflammation and injury can be restored by dexamethasone (Dex). To prevent the systemic negative side effects of free Dex, we targeted Dex by delivering anti-E-selectin Dex liposomes into activated endothelium of inflamed lungs.
The Scope and Mechanism of Phosphonium-Mediated SNAr Reactions in Heterocyclic Amides and Ureas (2007)

An efficient "one-step" synthesis of cyclic amidines and guanidines has been developed. Treatment of cyclic amides and ureas with benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP), base, and nitrogen nucleophiles leads to the formation of the corresponding cyclic amidines and guanidines, typically in good to excellent yields. This method has also been used to prepare heteroaryl ethers and thioethers using phenol and thiophenol nucleophiles. Time course NMR and HPLC-MS studies have facilitated explicit characterization of the proposed intermediates (the phosphonium salt and HOBt adduct); the data reveal a stepwise reaction pathway.
Description and Analysis of Manufacturing System Engineering Process (2002)

Planning, design and evaluation processes of manufacturing systems are very complicated, and individual manufacturing engineers carry out manufacturing system design based on their own experiences. It is now eagerly required to establish systematic methods and supporting tools, in order to support all the engineering processes for the planning, design and evaluation of the manufacturing systems. The objective of the research is to describe and analyze the actual manufacturing system engineering (MSE) processes in order to establish systematic methods and computerized support systems for the MSE processes.
Photoemission from Pyrene and its Derivatives (1975)

Abstract Photoemissions from pyrene and its derivatives, 1,3,6,8-tetrachloropyrene(TClP), 1,3,6,8-tetrabromopyrene(TBrP), 1,6-dicyanopyrene(CDNP), 1,3,6,8-tetracyanopyrene(TCNP), and 1,3,6,8-tetranitropyrene (TNO2P), were measured. Their photoelectron energy distribution curves(EDCs) were thus obtained; the peaks or shoulder appearing on the EDCs correspond to the ionization potentials of the pyrene molecule. Further, the spectral dependences of their quantum yields(SDQYs) were measured. The ionization potentials obtained from their threshold values were 5.8 eV(pyrene), 6.3 eV(TClP), 6.0 eV (TBrP), 6.3 eV(DCNP), 6.2 eV(TCNP), and 6.6 eV(TNO2P).
Identification of a Protein Kinase from Dictyosteliumwith Homology to the Novel Catalytic Domain of Myosin Heavy Chain Kinase A (1997)

Myosin II assembly and localization into the cytoskeleton is regulated by heavy chain phosphorylation in Dictyostelium. The enzyme myosin heavy chain kinase A (MHCK A) has been shown previously to drive myosin filament disassembly in vitro and in vivo. MHCK A is noteworthy in that its catalytic domain is unrelated to the conventional families of eukaryotic protein kinases. We report here the cloning and initial biochemical characterization of another kinase from Dictyostelium that is related to MHCK A. When the segment of this protein that is similar to the MHCK A catalytic domain was expressed in bacteria, the resultant protein displayed efficient autophosphorylation, phosphorylated Dictyostelium myosin II, and also phosphorylated a peptide substrate corresponding to a portion of the myosin II tail. We have therefore named this gene myosin heavy chain kinase B. These results provide the first confirmation that sequences in other proteins that are related to the MHCK A catalytic domain can also encode protein kinase activity. It is likely that the related segments of homology present in rat eukaryotic elongation factor-2 kinase and a putative nematode eukaryotic elongation factor-2 kinase also encode the catalytic domains of those enzymes.
Impact of Rye Kernel-Based Evening Meal on Microbiota Composition of Young Healthy Lean Volunteers With an Emphasis on Their Hormonal and Appetite Regulations, and Blood Levels of Brain-Derived Neurotrophic Factor (2018)

Rye kernel bread (RKB) evening meals improve glucose tolerance, enhance appetite regulation and increase satiety in healthy volunteers. These beneficial effects on metabolic responses have been shown to be associated with increased gut fermentation. The present study aimed to elucidate if RKB evening meals may cause rapid alterations in microbiota composition that might be linked to metabolic-, immune-, and appetite- parameters. Gut-brain axis interaction was also studied by relating microbiota composition to amount of brain-derived neurotrophic factor (BDNF) in blood plasma. Nineteen healthy volunteers, ten women and nine men aged 22-29 years, BMI < 25 (NCT02093481) participated in the study performed in a crossover design. Each person was assigned to either white wheat bread (WWB) or RKB intake as a single evening meal or three consecutive evenings. Stool and blood samples as well as subjective appetite ratings were obtained the subsequent morning after each test occasion, resulting in four independent collections per participant (<i>n</i> = 76). DNA was extracted from the fecal samples and V4 hypervariable region of the bacterial 16S rRNA genes was sequenced using next generation sequencing technology. Higher abundance of <i>Prevotella</i> and <i>Faecalibacterium</i> with simultaneous reduction of <i>Bacteroides</i> spp. were observed after RKB meals compared to WWB. The associations between metabolic test variables and microbiota composition showed a positive correlation between <i>Bacteroides</i> and adiponectin levels, whereas only <i>Prevotella</i> genus was found to have positive association with plasma levels of BDNF. These novel findings in gut-brain interactions might be of importance, since decreased levels of BDNF, that plays an essential role in brain function, contribute to the pathogenesis of several major neurodisorders, including Alzheimer's. Thus, daily consumption of <i>Faecalibacterium-</i> and/or <i>Prevotella</i>-favoring meals should be investigated further for their potential to prevent neurodegenerative processes in the brain.
Virtual Cord Protocol (VCP): A flexible DHT-like routing service for sensor networks (2008)

Efficient data management techniques are needed in wireless sensor networks (WSNs) to counteract issues related to limited resources, e.g. energy, memory, bandwidth, as well as limited connectivity. Self-organizing and cooperative algorithms are thought to be the optimal solution to overcome these limitations. On an abstract level, structured peer-to-peer protocols provide O(1) complexity for storing and retrieving data in the network. However, they rely on underlayer routing techniques. In this paper, we present the virtual cord protocol (VCP), a virtual relative position based efficient routing protocol that also provides means for data management, e.g. insert, get, and delete, as known from typical distributed hash table (DHT) services. The key contributions of this protocol are independence of real location information by relying on relative positions of neighboring nodes, short virtual paths because successors and predecessors are in their vicinity, and high scalability because only information about direct neighbors is needed for routing. Furthermore, VCP inherently prevents dead-ends and it is easy to be implemented.
Increased IL-15 production of muscle cells in polymyositis and dermatomyositis (2002)

In polymyositis (PM)/dermatomyositis (DM), various cytokines, especially macrophage-derived cytokines such as IL-1alpha, IL-1beta and tumor necrosis factor (TNF)-alpha, are expressed in the inflammatory foci. We previously reported that IL-15, a novel cytokine with a biological activity similar to that of IL-2, is expressed in muscle cells in PM/DM. In the present study, we set out to investigate the regulation of IL-15 in cultured myoblasts. Myoblasts constitutively produced a low level of IL-15 and the production was augmented by stimulation with IFN-gamma, IL-1alpha, IL-1beta, TNF-alpha or lipopolysaccharide (LPS) in a dose-dependent manner. These stimuli also enhanced the expression of IL-15 mRNA. About 30-40% of IL-15 was detected intracellularly, while the rest was released into the culture supernatant. Immunohistochemical staining revealed that intracellular IL-15 was localized in the perinuclear area of the cytoplasm in the myoblasts. Despite the considerable amounts of intracellular IL-15, the myoblasts predominantly expressed authentic IL-15 mRNA isoform. This isoform generates IL-15 with long signal peptide preprotein, which is all to be secreted. The biological activity of IL-15 secreted from the myoblasts was examined using an IL-15-dependent murine T cell line, CTLL-2. Culture supernatants of the myoblasts induced a proliferative response of CTLL-2 and this was specifically inhibited by anti-IL-15 antibody. These results suggest that inflammatory stimuli induce the production of IL-15 in the muscle cells in PM/DM, and IL-15 may contribute to the immunopathogenesis by augmenting recruitment and activation of the infiltrating T cells. Blocking of IL-15 production might be of therapeutic value in PM/DM.
Enantioselective Total Synthesis of a Potent Antitumor Antibiotic, Fredericamycin A (2001)

The asymmetric total synthesis of both enantiomers of the potent antitumor antibiotic fredericamycin A (1) is detailed based on the protocol for the construction of its peri-hydroxy polyaromatic skeleton bearing the chirality at the spiro carbon via a strong base-induced cycloaddition of suitably substituted homophthalic anhydrides (AB-ring unit) with an optically active CDEF-ring unit. Particular attention has been given to the novel synthesis of the optically active spiro carbon center by a stereospecific rearrangement of optically active benzofuzed-trans-epoxy acylates leading to spirocyclopentane-1,1'-indane systems. This method is quite useful for the construction of an optically active spiro compound and was applied to the synthesis of the optically pure CDEF-ring unit of 1. Cycloaddition of the optically pure CDEF-ring unit to AB-ring units prepared via benzyne afforded two natural and unnatural-type hexacyclic compounds, which were converted to natural and unnatural enantiomers of synthetic 1, and the absolute configuration of natural 1 was determined as S.
Fault detection and identification in Petri net controllers (2004)

This paper proposes a methodology for providing fault tolerance to Petri net controllers. In order to provide tolerance against faults that may compromise the functionality of the Petri net controller, we construct a redundant Petri net embedding that allows the detection and identification of place and transition faults. A place fault results in an incorrect token-load of a place, and a transition fault arises when the token-load of either the input or output place-set of a transition is not appropriately updated following the firing of a transition. The resulting Petri net controller implementations use redundant places, connections and tokens to impose invariant conditions that allow the detection and identification of faults via linear parity checks. The proposed methodology is attractive because the redundant Petri net controller makes efficient use of redundancy and allows for the systematic detection and identification of faults. More specifically, the use of d redundant places enables the detection and identification of up to d - 1 transition faults and up to [d/2] place faults.
Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation. (1994)

Most gut intraepithelial cells (IEL) of the mouse are T cells that bear CD8 molecules, present either as alpha-beta chain heterodimers (CD8 beta+) or as alpha chain homodimers (CD8 beta-). All CD8 beta+ IEL bear alpha/beta T cell receptors (TCR); CD8 beta- IEL bear either alpha/beta or gamma/delta TCR and are considered to be a thymus-independent (TI) population, probably arising locally from a small fraction of CD3- IEL containing the recombinant activating gene RAG proteins. Here we report that TI CD8 beta- IEL, whether bearing alpha/beta or gamma/delta TCR, contain, in normal mice, mRNAs for both zeta and Fc epsilon RI gamma chains. These chains are present in their CD3-TCR complexes as homo- or heterodimers. In contrast, only zeta chain mRNA and homodimers are found in gut CD8 alpha/beta+ IEL and in peripheral T lymphocytes. Intestinal CD3- precursor cells contain only gamma chain, and CD3- IL-2R+ thymocyte precursors only zeta chain mRNAs. Only very primitive thymocyte precursors contain detectable gamma chain mRNA, and it thus appears that Fc epsilon RI gamma chain use is switched off at a very early stage during thymocyte differentiation. Thus, T cell differentiation in the gut epithelium differs from that occurring in the thymus, from which CD8 beta+ IEL appear to derive. Use of different TCR transducing modules and CD8 accessory molecules between the TI and the thymus-derived T cell populations provides an explanation for their difference in reactivity to antigenic stimulations and thus in selection of repertoires.
Influencia de la superficie de Brackets ortodóncicos mediante aparatos de bicarbonato (1997)

El presente estudio pretende aclarar si se deben esperar modificaciones en los Brackets ortodoncicos a causa del uso continuo de aparatos de bicarbonato. Para realizarlo se rociaron 14 Brackets de acero, plastico o ceramica con diferentes aparatos de bicarbonato y, seguidamente, se exploraron mediante un microscopio electronico reticulado. Mientras que los Brackets de acero o ceramica no presentaban ninguna modificacion clinicamente relevante, en cambio en los Brackets de plastico presentaron efectos visibles con la aparicion de las particulas de relleno, el redondeado de los cantos y el escalonamiento entre el metal y el plastico. Clinicamente, las diferencias de efecto de los cuatro aparatos de bicarbonato no son relevantes. Para minimizar el efecto no deseado de aparatos de bicarbonato se recomienda, en primer lugar, tenir los depositos a limpiar y finalizar el rociado inmediatamente despues de haber eliminado la placa.
(Quintessenz 1996; 47:219-227)
Experiment and Simulation Effects of Cyclic Pitch Control on Performance of Horizontal Axis Wind Turbine (2017)

Offshore wind is generally stronger and more consistent than wind on land. A large part of the offshore wind resource is however located in deep water, where floating wind turbines can harvest more energy. This paper describes a systematic experiment and a simulation analysis (FAST code) about the cyclic pitch control of blades. This work was performed to investigate performance fluctuation of a floating wind turbine utilizing cyclic pitch control. The experiment was carried out in an open wind tunnel with mainstream wind velocity of 10 m/s with the front inflow wind and the oblique inflow wind conditions. A model wind turbine is two-bladed downwind wind turbine with diameter of 1.6 m. Moment and force acts on the model wind turbine were measured by a six-component balance. Fluctuation of power coefficient and thrust coefficient was investigated in the cyclic pitch control. The model wind turbine and the experimental conditions were simulated by FAST code. The comparison of the experimental data and the simulation results of FAST code show that the power coefficient and thrust coefficient are in good agreement. Keywords: Floating Offshore Wind Turbine, Aerodynamic Forces, Cyclic Pitch Control, FAST Code, Wind Tunnel ExperimentArticle History: Received February 11st 2017; Received in revised form April 29th 2017; Accepted June 2nd 2017; Available onlineHow to Cite This Article: Sang, L.Q., Maeda, T., Kamada, Y. and Li, Q. (2017) Experiment and simulation effect of cyclic pitch control on performance of horizontal axis wind turbine to International Journal of Renewable Energy Development, 6(2), 119-125.https://doi.org/10.14710/ijred.6.2.119-125
Surface Diffusion during Decay of 2-Dimensional Island on Si(100) (2003)

Surface diffusion during decay of a two-dimensional (2D) island at approximately 800 K on Si(100) is studied using kinetic Monte Carlo simulation and scanning tunneling microscopy (STM). The decay is a diffusion-limited attachment/detachment process, but the diffusion is not that of a specific adatom from the island. The diffusing adatom is substituted by a terrace atom via a process in which the diffusing adatom fills a vacancy left behind by the hopping up of a terrace atom, which then becomes a diffusing adatom.
Identification of CD14 and lipopolysaccharide-binding protein as novel biomarkers for sarcoidosis using proteomics of serum extracellular vesicles (2022)

Sarcoidosis is a complex, polygenic, inflammatory granulomatous multi-organ disease of unknown cause. The granulomatous inflammation in sarcoidosis is driven by the interplay between T cells and macrophages. Extracellular vesicles (EVs) play important roles in intercellular communication. We subjected serum EVs, isolated by size exclusion chromatography, from seven patients with sarcoidosis and five control subjects to non-targeted proteomics analysis. Non-targeted, label-free proteomics analysis detected 2292 proteins in serum EVs; 42 proteins were up-regulated in patients with sarcoidosis relative to control subjects; and 324 proteins were down-regulated. The protein signature of EVs from patients with sarcoidosis reflected disease characteristics such as antigen presentation and immunological disease. Candidate biomarkers were further verified by targeted proteomics analysis (selected reaction monitoring) in 46 patients and 10 control subjects. Notably, CD14 and lipopolysaccharide-binding protein (LBP) were validated by targeted proteomics analysis. Up-regulation of these proteins was further confirmed by immunoblotting, and their expression was strongly increased in macrophages of lung granulomatous lesions. Consistent with these findings, CD14 levels were increased in lipopolysaccharide-stimulated macrophages during multinucleation, concomitant with increased levels of CD14 and LBP in EVs. The area under the curve values of CD14 and LBP were 0.81 and 0.84, respectively, and further increased to 0.98 in combination with angiotensin-converting enzyme and soluble interleukin-2 receptor. These findings suggest that CD14 and LBP in serum EVs, which are associated with granulomatous pathogenesis, can improve the diagnostic accuracy in patients with sarcoidosis.
The use of an inhomogeneous applied field improves the spatial sensitivity profile of anin vivoSQUID susceptometer (1999)

We present a SQUID susceptometer with a non-homogeneous magnetizing field which is null at the sensing coil and increases towards the patient position with a constant gradient plus a cubic term at large distances. Compared with the magnetizing fields of similar instruments described in the literature, our gradient field enhances the signal due to internal organs with respect to the signal due to superficial tissue. Preliminary measurements have been performed on phantoms of known magnetic susceptibility. The advantage of using a non-homogeneous field compared with a uniform field has been investigated in the case of a double-layer phantom.
Kinetoplast DNA of Bodo caudatus: a Noncatenated Structure (1986)

The kinetoplast DNA (kDNA) of trypanosomes and other parasitic members of the order Kinetoplastida is organized as a complex network containing thousands of catenated circular DNA molecules. We found that the kDNA of a free-living kinetoplastida, Bodo caudatus, exists as a noncatenated structure. The kDNA of B. caudatus represents about 40% of the total cellular DNA, and the major components of this DNA are large circles of 10 and 12 kilobases (kb). Our results indicate that these circles are analogous to trypanosome kDNA minicircles despite their large size and noncatenated form. The kDNA of B. caudatus also contains a minor component of 19 kb which is transcribed. The 19-kb molecules are probably analogous to the maxicircles of trypanosomes. The properties of the B. caudatus kDNA suggest that the catenated network structure of trypanosome kDNA is not required for maxicircle segregation during kinetoplast division or for the expression of the maxicircle genome.