gebhart/patrepeval huggingface dataset:
Detection of Circulating Cancer Cells by RT-PCR in Patients with Resectable Lung Cancer. (1995)

上皮性細胞の特異的なマーカーであるケラチン19の発現をRT-PCR法により検出する高感度のアッセイ系を用いて, 肺癌切除症例について末梢血中の癌細胞の存在を検討した. 本アッセイ系では, 正常人血液ではケラチン19の発現を検出し得なかったのに対し, 肺腺癌細胞株CADO-LC4では106希釈まで検出し得た. 原発性肺癌切除症例21例 (I期11例, II期2例, III期8例) より術前に採取した末梢血について調べたところ, I期の3例にのみケラチン19の発現を検出し, 末梢血中の癌細胞の存在が示された. ケラチン19の陽性率と血管侵襲の有無との間に正の相関は認めなかったが, 組織型では扁平上皮癌が腺癌より高い傾向がみられた. 血液中に癌細胞が存在することが潜在的な遠隔転移の存在を反映するか否かは, 充分な観察期間を経過した後の遠隔転移出現の有無との比較検討の結果を待たねばならない.
Study on the correlation between CD4~+ cytotoxic T and course of primary hepatocellular carcinoma (2013)

Objective 　To investigate the proportion of CD4+ T cells, which express the granzyme A, B and perforin, in peripheral blood of patients with primary hepatocellular carcinoma (PHCC), and explore the correlation between CD4+ T and the course of PHCC. Methods 　Peripheral blood samples were obtained from 99 PHCC patients, 28 chronic hepatitis B (CHB) patients, and 40 healthy subjects (served as control), and CD4+ cytotoxic T cells in peripheral blood were quantitatively analyzed with flow cytometry. The difference of proportion of CD4+ T cells between early (n=29), intermediate (n=36) and progressive (n=34) stage of PHCC patients was also analyzed. Results 　It was revealed that the proportions of granzyme A+ CD4+ CTL, granzyme B+ CD4+ CTL and perforin+ CD4+ CTL were significantly higher in PHCC patients (15.38%±10.36%, 11.10%±8.43% and 7.42%±7.26%) compared with those in CHB patients (9.10%±5.80%, 6.16%±6.04% and 2.95%±3.34%) and healthy controls (10.25%±5.62%, 6.82%±6.12% and 3.14%±3.60%, P<0.05), but no statistical difference of the values existed between CHB patients and healthy controls. The proportions of granzyme A+ CD4+ CTL in early, intermediate and progressive stage of PHCC patients were 21.26%±12.61%, 14.54%±7.11% and 11.24%±9.04%, and of granzyme B+ CD4+ CTL were 15.35%±10.30%, 10.71%±6.06% and 7.90%±7.44%, and of perforin+ CD4+ CTL were 11.82%±9.17%, 7.16%±5.03% and 5.22%±6.58%, respectively. The proportions of CD4+ CTL declined along with the deterioration of PHCC. Conclusion 　The proportion of CD4+ CTL increases in the peripheral blood of PHCC patients, but it declines along with the deterioration of disease, implying that the CD4+ cytotoxic T may be closely associated with the deterioration of PHCC.
Ultra-Low Amounts of Palladium (0.005-0.05 Wt% Pd) Supported on Titania: Remarkable Low-Temperature Activity for NO Reduction with CO and Structure-Function Property Relationships in Methane Oxidation (2020)

Atomically dispersed Pd +2 cations with ultra-dilute loading of palladium (0.005-0.05 wt%) were anchored on anatase titania and characterized with FTIR, microscopy and catalytic tests. CO infrared adsorption produces a sharp, narrow mono-carbonyl Pd(II)-CO band at ~2,130 cm-1 indicating formation of highly uniform and stable Pd+2 ions on anatase titania. The 0.05 wt% Pd/TiO2 sample was evaluated for methane combustion under dry and wet (industrially relevant) conditions in the presence and absence of carbon monoxide. Notably, we find the isolated palladium atoms respond dynamically upon oxygen concentration modulation (switching-on and switching off). When oxygen is removed from the wet methane stream, palladium ions are reduced to metallic state by methane and catalyze methane steam reforming instead of complete methane oxidation. Re-admission of oxygen restores Pd+2 cations and switches off methane steam reforming activity. Moreover, 0.05 wt% Pd/TiO2 is a competent CO oxidation catalyst in the presence of water steam with 90% CO conversion and TOF ~ 4,000 hr-1 at 260 ⁰C. More importantly, we find that diluting 0.05 wt% Pd/titania sample with titania to ultra-low 0.005 wt% palladium loading produces a remarkably active material for nitric oxide reduction with carbon monoxide under industrially relevant conditions with >90% conversion of nitric oxide at 180 ⁰C (~460 ppm NO and 150 L/g*hr flow rate in the presence of >2% water steam) and TOF ~6,000 hr-1. Pd thus outperforms state-of-the-art rhodium containing catalysts with (15-20 times higher rhodium loading; rhodium is ~ 3 times more expensive than palladium). Furthermore, palladium catalysts are more selective towards nitrogen and produce significantly less ammonia relative to the more traditional rhodium catalysts due to lower Pd amount nd lower water-gas-shift activity. Our study is the first example of utilizing ultra-low (0.05 wt% and less) noble metal (Pd) amounts to produce heterogeneous catalysts with extraordinary activity for nitric oxide reduction. This opens up a pathway to study other Pd, Pt and Rh containing materials with ultra-low loadings of expensive noble metals dispersed on titania or titania-coated oxides for industrially relevant nitric oxide abatement.
Kristallisation und Polymorphie von AlPO4 und AlPO4-SiO2-Mischkristallen (1967)

Article Kristallisation und Polymorphie von AlPO4 und AlPO4-SiO2-Mischkristallen was published on December 1, 1967 in the journal Zeitschrift für Kristallographie - Crystalline Materials (volume 125, issue 1-6).
Academic refugees (2009)

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A-54 | The Disrupt CAD III Post-Approval Study: Real-World Safety and Effectiveness of Coronary Intravascular Lithotripsy from the ACC NCDR CathPCI Registry (2023)

Background: Data on anticoagulant (AC) use in chronic kidney disease (CKD) patients (pts) undergoing percutaneous coronary intervention (PCI) is scarce.Unfractionated heparin (UFH) or bivalirudin are treatments of choice.We assessed major bleeding and major adverse cardiac and cerebrovascular events (MACCE) in CKD (eGFR<60 mL/min/ 1.73 m 2 ) pts undergoing PCI with either UFH or Bivalirudin and whether femoral vs. radial access modified the relationship of AC choice and outcomes.Methods: Data was collected on all CKD pts who underwent PCI from 2010 to 2018.Bleeding was classified by Bleeding Academic Research Consortium (BARC) criteria.BARC 4 and 5 were excluded.Results: A total of 3844 pts had femoral access and 1,421 pts had radial access; 2533 pts got UFH and 2732 pts got bivalirudin (Table ).Bivalirudin was used in 68% of femoral access and 7.5% of radial access.Among femoral access pts, the odds of major bleeding (BARC!3) were greater among UFH pts compared to bivalirudin pts (OR: 1.8, CI:1.4-2.4).An interaction existed between AC and access site for odds of MACCE (p0.02) but not for odds of BARC!3.Among femoral access pts, no effect of AC on MACCE was found, but among radial access pts, odds of MACCE were higher for bivalirudin pts compared to UFH pts (OR 2.0, CI:1.1-3.5).Conclusions: To summarize: 1) bivalirudin was used in the majority of pts undergoing femoral access PCI; 2) Among femoral access pts, the choice of AC had no impact on the odds of MACCE but the odds of BARC!3 were greater in pts treated with UFH vs. pts treated with Bivalirudin; 3) Among radial access pts, the odds of MACCE were greater in pts treated with bivalirudin vs. pts treated with UFH.
Effects of wheel running duration on osteoarthritis‐induced shifts in hind limb weight bearing in rats (2010)

We are developing methods to characterize the potency/efficacy of chronic pain states to suppress feeding, locomotor activity and wheel running. The present study describes a serendipitous finding that wheel running, when manipulated as an independent variable, attenuates osteoarthritis‐induced shifts in hind limb weight bearing. Rats were given intra‐articular saline or monosodium iodoacetate (MIA, 3.2mg) into the left hind knee. Rats were divided into three groups. Group 1 had 24 hr voluntary access to running wheels for 42 consecutive days (21 days acquisition followed by 21 days post‐MIA). Group 2 had 24 hr voluntary access to running wheels for 21 consecutive days (0 days acquisition followed by 21 days post‐MIA). Group 3 had no access to running wheels for 21 consecutive days (21 days post‐MIA). Weight bearing was measured on post‐MIA days 3, 7, 14 and 21. MIA produced robust and reliable shifts in weight bearing in non‐runners. In contrast, runners demonstrated a duration‐dependent attenuation of MIA‐induced shifts in weight bearing. These results suggest that voluntary wheel running may be protective against osteoarthritis pain. Parallel experiments are being conducted to determine the effects of wheel running duration on MIA‐induced damage to cartilage, subchondral bone and muscle. Funded by NIAMS grant R15 AR054975‐01 (GWS).
Mobile Social Data Learning for User-Centric Location Prediction With Application in Mobile Edge Service Migration (2019)

Recently, location prediction has attracted considerable research effort because of the popularity of location-based services, such as mobile advertising and recommendations. With the unprecedented proliferation of mobile social networks, such as WeChat and Twitter, we are able to use location service to bridge the online and offline worlds, which is of great significance to many smart city applications. Different from existing studies, in this paper, we promote a user-centric location prediction approach by leveraging a user's local mobile social information without involving other users' location privacy. We propose a factor graph learning model that integrates not only user's social and network information but also the correlations between a user's locations into a unified framework. Furthermore, we use ReliefF algorithm to select user-specific significant features for location prediction and define the measure of location entropy to study the similarity between location, network status, and social behavior. To show the benefit of precise location prediction, we further apply it to personalized service migration in mobile edge computing (MEC) and accordingly propose prediction-based amortizing algorithm and lazy migration algorithm that can well balance the tradeoff between migration cost and non-migration latency in a cost-efficient manner. We conduct extensive experiments using a real-world data trace, which shows that our model performs much better in location prediction compared with several classic methods and the MEC service quality can be significantly enhanced by leveraging the location prediction.
Pd-Catalyzed C−C Cross-Coupling Reactions within a Thermoresponsive and pH-Responsive and Chelating Polymeric Hydrogel (2009)

A porous, thermoresponsive and pH-responsive, and chelating hydrogel of poly(N-isopropylacrylamide)-co-poly[2-methacrylic acid 3-(bis-carboxymethylamino)-2-hydroxypropyl ester] (PNIPAM-co-PMACHE) is proposed as both a reaction medium and the Pd catalyst support for organic synthesis. Organic synthesis within the PNIPAM-co-PMACHE hydrogel has three merits. First, organic reactions such as Suzuki and Heck reactions within the hydrogel can be accelerated due to the enriched Pd catalyst and reactants within the hydrogel by the reversible deswelling/swelling. Second, organic synthesis within the PNIPAM-co-PMACHE hydrogel, which holds about approximately 300 times of water and is similar to the environmentally benign reaction medium of water, can be performed efficiently without surfactant or cosolvent being added. Third, the PNIPAM-co-PMACHE hydrogel itself and the therein-immobilized Pd catalyst can be easily recycled since the hydrogel/Pd composite can reversibly swell/deswell.
Combined effects of anisotropy and tension-compression asymmetry on the\n torsional response of AZ31 Mg (2014)

In this paper it is demonstrated that only by accounting for the combined\neffects of anisotropy and tension-compression asymmetry both at single crystal\nand polycrystal levels, it is possible to explain and accurately predict the\npeculiarities of the room-temperature torsional response of a strongly textured\nAZ31 Mg material. This is shown by using two modeling frameworks, namely: the\nviscoplastic self-consistent (VPSC) polycrystal model that accounts for\ntension-compression asymmetry of the mechanical response of a polycrystalline\naggregate due to the occurrence of twinning at single crystal level, and an\nanisotropic plasticity model based on an orthotropic yield criterion that\naccounts for tension-compression asymmetry in plastic flow at macroscopic\nlevel, developed by Cazacu et al. (2006). It is shown that unlike Hill's\n(1948), the latter macroscopic criterion quantitatively predicts the\nexperimental results, namely: that the sample with axial direction along the\nrolling direction contracts, while the sample with axial direction along the\nnormal direction elongates. Moreover, it is demonstrated that these\nexperimentally observed axial effects in torsion can be also quantitatively\npredicted with the VPSC polycrystal model only if both slip and twinning are\nconsidered active at single crystal level. On the other hand, if it is assumed\nthat the plastic deformation is fully accommodated by crystallographic slip,\nthe predicted axial strains are very close with that obtained with Hill (1948)\ncriterion, which largely underestimate the measured axial strains.\n
Targeting Integrins in Cancer Nanomedicine: Applications in Cancer Diagnosis and Therapy (2019)

Due to advancements in nanotechnology, the application of nanosized materials (nanomaterials) in cancer diagnostics and therapeutics has become a leading area in cancer research. The decoration of nanomaterial surfaces with biological ligands is a major strategy for directing the actions of nanomaterials specifically to cancer cells. These ligands can bind to specific receptors on the cell surface and enable nanomaterials to actively target cancer cells. Integrins are one of the cell surface receptors that regulate the communication between cells and their microenvironment. Several integrins are overexpressed in many types of cancer cells and the tumor microvasculature and function in the mediation of various cellular events. Therefore, the surface modification of nanomaterials with integrin-specific ligands not only increases their binding affinity to cancer cells but also enhances the cellular uptake of nanomaterials through the intracellular trafficking of integrins. Moreover, the integrin-specific ligands themselves interfere with cancer migration and invasion by interacting with integrins, and this finding provides a novel direction for new treatment approaches in cancer nanomedicine. This article reviews the integrin-specific ligands that have been used in cancer nanomedicine and provides an overview of the recent progress in cancer diagnostics and therapeutic strategies involving the use of integrin-targeted nanomaterials.
An analysis of multiple biomarkers to better predict prostate cancer metastasis and death after radical prostatectomy. (2018)

54 Background: Identification of potentially lethal disease at the time of diagnosis with localized prostate cancer (PCa) remains a significant clinical issue despite a plethora of candidate biomarkers. This study evaluates a range of biomarkers previously associated with biochemical relapse (BR) in localized PCa to determine whether a combined expression model can improve detection of clinically significant cases. Methods: The Australian PCa Research Centre NSW has completed 23 studies of molecular biomarkers associated with BR in a well-described localized PCa cohort (n=324, median followup 16 years). 12 studies were excluded due to missing data. Each biomarker was analyzed as a marker for metastatic-free survival (MFS) and prostate cancer specific survival (PCSS) and then used to develop a prognostic model for clinical outcomes incorporating clinico-pathological factors. This model is currently being validated in an independent cohort. Results: The PCa cohort experienced 39 metastatic relapses (12%) and 23 PCa deaths (7%). Of 12 biomarkers (AR, AZPG1, C0S, Cyclin D1a, Cyclin D1b, E6AP, H3K18Ac, H3K4me2, Ki67, p53, PML, SGTA) assessed, only AZGP1 and Ki67 were associated with MFS (HR 2.9, 95% CI, 1.4-5.6; P=0.002, and HR 1.2, 95% CI, 1.0-1.4; P=0.03, respectively) and PCSS (HR 4.2, 95% CI, 1.7-10.5; P=0.002; and HR 1.2, 95% CI, 1.0-1.5; P=0.04, respectively). The combined panel of AZGP1 and Ki67 was an independent predictor of MFS (HR 1.9, 95% CI, 1.1-3.2; P=0.01), and PCSS (HR 3.3, 95% CI, 1.5-7.3; P=0.002) when modeled with known clinicopathological variables. The panel was more robust in predicting MFS and PCSS compared to the individual biomarkers alone and superior to other prognostic models (See table). Data from the validation cohort will be available for the meeting. Conclusions: Our novel signature of AZPG1 and Ki67 improves existing prognostication tools in predicting PCa metastasis and death. [Table: see text]
ChemInform Abstract: Radical Cyclization of Allyl Propargyl Ethers and Acetals: Application to the Stereocontrolled Acylation of Carbohydrates. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Region of Interest Evaluation of SPECT Image Reconstruction Methods (1997)

A realistic numerical brain phantom, developed by Zubal et al, was used for a region-of-interest evaluation of the accuracy and noise variance of the following SPECT reconstruction methods: 1) Maximum-Likelihood reconstruction using the Expectation-Maximization (ML-EM) algorithm; 2) an EM algorithm using ordered-subsets (OS-EM); 3) a re-scaled block iterative EM algorithm (RBI-EM); and 4) a filtered backprojection algorithm that uses a combination of the Bellini method for attenuation compensation and an iterative spatial blurring correction method using the frequency-distance principle (FDP). The Zubal phantom was made from segmented MRI slices of the brain, so that neuro-anatomical structures are well defined and indexed. Small regions-of-interest (ROIs) from the white matter, grey matter in the center of the brain and grey matter from the peripheral area of the brain were selected for the evaluation. Photon attenuation and distance-dependent collimator blurring were modeled. Multiple independent noise realizations were generated for two different count levels. The simulation study showed that the ROI bias measured for the EM-based algorithms decreased as the iteration number increased, and that the OS-EM and RBI-EM algorithms (16 and 64 subsets were used) achieved the equivalent accuracy of the ML-EM algorithm at about the same noise variance, with much fewer number of iterations. The Bellini-FDP restoration algorithm converged fast and required less computation per iteration. The ML-EM algorithm had a slightly better ROI bias vs. variance trade-off than the other algorithms.
Ultrasound-modulated optical computed tomography of biological tissues (2004)

An optical imaging technique called ultrasound-modulated optical computed tomography is demonstrated for tomographic imaging of biological tissues. Ultrasound-modulated optical signals are extracted from scattered light to provide projection data for the image reconstruction. A filtered back-projection algorithm is implemented to reconstruct an image reflecting optical tissue properties from angular and linear scans of an ultrasonic beam across a sample. This reconstruction-based imaging technique provides a way to obtain images of cross sections containing the scanned ultrasonic axis in biological tissues, which enables three-dimensional ultrasound-modulated optical imaging. The technique combines the contrast advantage of optical waves and the resolution advantage of ultrasonic waves.
The influence of body effect on the short-circuit ruggedness of emitter ballasted IGBTs (2002)

In this paper, we show that a dynamic increase in threshold voltage due to the high body effect coefficient in IGBTs contributes significantly to the improved short-circuit ruggedness in emitter ballasted IGBTs. We find that due to the nonlinear doping concentration in the DMOS channel, the body effect coefficient is high. Using analytical modeling and through numerical simulations, we show that the high body effect leads to a dynamic increase in V/sub th/ at high currents. Thus, a very small (50-100 mV) drop in the ballast resistor under normal operating currents will produce a 2-4 V increase in threshold voltage under short-circuit fault conditions. This greatly reduces the peak current through the device, increasing the short-circuit withstand time (SCWT). Experimental devices fabricated according to these principles demonstrate high short-circuit robustness with only minimal degradation of conduction drop.
Clinical prediction rule for SARS-CoV-2 infection from 116 U.S. emergency departments 2-22-2021 (2021)

Criteria that are available at the point of care can accurately predict the probability of SARS-CoV-2 infection. These criteria could assist with decisions about isolation and testing at high throughput checkpoints.
White-light transmission reflection interference technology application in three-dimensional reconstruction method validation for microstructures (2010)

In this paper the reconstructed method of three-dimensional morphology validated by the method of transmission reflection interference for GaAs steps structure, which is deposited by transparent film. As drove by Pizeo, the surface of different height can reach the position of zero optical path different, and during the whole of scanning, the change of interference fringe can be recorded by CCD, and then the three-dimensional morphology information of sample can be extracted. This technique of measurement has noncontact, nondestructive, high sensitivity and fast measurement characteristic. Relative indication error and relative repeatability error is controlled within the range of 5% respectively, according to the method of national metrology department.
Ammonium Tetrafluoborate (1946)

Reaction in Aqueous Solution Fusion Reaction
Analysis and Phase Control of a Piezoelectric Traveling-Wave Ultrasonic Motor for Haptic Stick Application (2004)

An original modeling of a traveling-wave ultrasonic motor is established in order to provide a new torque control law for this category of actuators. In particular, self-driving is implemented, avoiding the classical drawbacks of frequency control, i.e., pull-out phenomenon. With such a robust control, force feedback application is available. Experimental results are obtained on an active haptic stick.