gebhart/patrepeval huggingface dataset:
Safety analysis by UGT1A1 status of TROPHY-U-01 cohort 1, a phase 2 study of sacituzumab govitecan (SG) in patients (pts) with metastatic urothelial cancer (mUC) who progressed after platinum (PT)-based chemotherapy and a checkpoint inhibitor (CPI). (2023)

4514 Background: SG, a Trop-2–directed antibody-drug conjugate, was granted FDA accelerated approval for pts with mUC previously treated with PT-based chemotherapy and a CPI. Approval was based on the pivotal TROPHY-U-01 Cohort 1 study of 113 pts, where SG demonstrated an objective response rate (ORR) of 27%, a median overall survival (OS) of 10.9 mo, and a manageable safety profile (median follow up 9.1 mo [range, 0-19.9], Tagawa et al. JCO 2021). A phase 3 confirmatory study TROPiCS-04 (NCT04527991) is ongoing. Here, we report updated safety outcomes by UGT1A1 status. Methods: Cohort 1 pts were ≥18 y, had progression of UC following PT and a CPI, and ECOG PS 0-1. Pts received SG 10 mg/kg on D1 and D8 of 21-D cycles (growth factor was allowed per investigator discretion). The primary endpoint was ORR per central review by RECIST 1.1. Post hoc safety analyses were exploratory with descriptive statistics reported. Results: As of July 26, 2022, the median follow-up was 10.5 mo (range, 0.3-40.9) for treated pts (N=113). As previously reported, pts were heavily pretreated with a median of 3 prior therapies (78% male; median age 66 y; 66% with visceral metastases). Known baseline comorbidities included chronic kidney disease (12%), coronary artery disease (10%), myocardial infarction (8%), and diabetes mellitus II (8%). Grade (Gr) ≥3 treatment-related adverse events (TRAEs) occurrence and treatment-related discontinuation were consistent with prior reports. In total, 94% of treated pts (n=106) had evaluable UGT1A1 status (wild-type [*1|*1], n=45 [42%]; heterozygous [*1|*28], n=47 [44%]; and homozygous [*28|*28], n=14 [13%]). Gr ≥3 TRAEs occurred in 62% of wild-type, 60% of heterozygous, and 79% of homozygous pts. The incidence of treatment-related any Gr diarrhea was 53%, 72%, and 71%, respectively; any Gr neutropenia was 38%, 55%, and 50%, respectively; and any Gr anemia was 38%, 32%, and 29%, respectively. The incidence of treatment-emergent Gr ≥3 diarrhea was 4%, 15%, and 7%, respectively; Gr ≥3 neutropenia was 31%, 36%, and 50%, respectively; and Gr ≥3 anemia was 13%, 19%, and 29%, respectively. TRAEs led to SG discontinuation in 7%, 6%, and 14% of pts with wild-type, heterozygous, and homozygous status, respectively; incidence of SG interruption was 42%, 43%, and 71%, respectively and incidence of SG dose reduction was 38%, 34%, and 43%, respectively. Conclusions: With longer follow-up, SG safety profile was consistent with prior reports. The incidence of adverse events varied across UGT1A1 subgroups, with dose interruptions being more frequently observed in homozygous pts. This was an exploratory analysis with relativity low numbers in each subgroup. Additional studies are needed to confirm the impact of UGT1A1 status on safety outcomes with SG in UC. Clinical trial information: NCT03547973 .
Animal models in the study of vomiting (1990)

The emetic responses to various pharmacological agents, cytotoxins, and radiation are compared among animal species. The species included for comparison are the human, nonhuman primate, dog, cat, and ferret. The categories of pharmacologic compounds include both those compounds that act on identified membrane receptors (e.g., cholinergic agonists, catecholamines, and neuroactive peptides) and those that act on unidentified receptors (e.g., cardiac glycosides and Veratrum alkaloids, among others). Emphasis is placed on emetic dose–response relations and threshold ED 50 and ED 100 values calculated from these relations, as indices of species sensitivity to emetic stimuli. For the more noxious emetics, the cytotoxins and radiation, the latency to the first emetic episode and duration of emesis are also compared across species. The effect that peripheral and central nerve lesions have on species differences in emetic responses to stimuli is also discussed.Key words: emesis, vomiting, ferret, dog, cat, nonhuman primate, model.
Virus del Papiloma Humano (2017)

VPH son las siglas para referirse al virus del papiloma humano (o HPV en ingles). Los VPH son un grupo de mas de 150 virus relacionados. A cada variedad de VPH en el grupo se le asigna un numero, lo que es llamado tipo de VPH. Los VPH son llamados virus del papiloma debido a que algunos tipos de VPH causan verrugas o papilomas, los cuales son tumores no cancerosos. Sin embargo, se sabe que algunos tipos de VPH son causantes de cancer, especialmente cancer de cuello uterino o cervical (la base de la matriz en la parte superior de la vagina). Los virus del papiloma son atraidos a ciertas celulas del cuerpo que son las unicas en las que pueden vivir; estas son las celulas epiteliales escamosas.
High dose irradiation to biopsy confirmed aortic node metastases from carcinoma of the uterine cervix (1977)

Twenty-one women with biopsy proven aortic node metastases from previously untreated carcinoma of the uterine cervix were treated with high dose irradiation to the pelvis and para-aortic areas. The majority received 6000 rads to the pelvis and para-aortic nodes by split course therapy plus 2500 rads by intracavitary radium to point A; 57.1% sustained severe complications to the stomach, small intestine or colon. Only 14.2% are surviving over 2 years free of recurrence. Though approximately 40% of women with Stages III and IV cervical cancer will have metastases to the para-aortic nodes, to date there is no satisfactory therapy that results in a significant number of such women surviving free of recurrent cervical cancer.
Memória organizacional de comunidades de prática como fator de vantagem competitiva das organizações (2009)

Este artigo apresenta uma análise de referências e estudo de caso sobre memória organizacional em Comunidades de Prática (CoP) como fator competitivo nas organizações. Inicia conceituando e analisando o papel da memória organizacional na gestão do conhecimento, a visão das comunidades de práticas e suas interações nas organizações. Mostra como a construção da memória organizacional é de fundamental importância nas organizações de sucesso e que estão na vanguarda tecnológica. A pesquisa realizada reflete a visibilidade de seus envolvidos: empregados e colaboradores, como também de seus líderes, identificando os principais fatores de vantagem competitiva e demonstrando suas percepções de influência no negócio. Os resultados obtidos evidenciam o potencial das CoPs para os negócios e vantagem competitiva, ao ampliarem a capacidade de atuação de equipes de projetos. Concluise que CoPs são elementos chave para construção do capital social que serve para possibilitar o compartilhamento de conhecimento e promover inovação.
Nuclear Pulse Propulsion - Orion and beyond (2000)

The race to the Moon dominated manned space Fight during the 1960's. and culminated in Project Apollo. which placed 12 humans on the Moon Unbeknownst to the public at that time, several U.S. Government agencies sponsored a project that could have conceivably, placed 150 people on the Moon and eventually sent crewed expeditions to Mars and the outer Planets. These feats could have possibly been accomplished during, the same period of time as Apollo. and for approximately the same cost. The project. code-named Orion. featured an extraordinary propulsion method known n as Nuclear Pulse The concept is probably as radical today as t was at the down of the space age. However its development appeared to he so promising that it was only by Political and non-technical considerations that it was not used to extend humanity reach throughout the solar system and quite possible to the stars. This paper discusses the rationale for nuclear pulse propulsion and presents a general history of the concept. focusing particularly on Project Orion. It describes some of the reexaminations being done in this area and discusses some of the new ideas that could mitigate many of the political and environmental issues associated with the concept.
MOLECULAR SIEVES — PREPARATION, PROPERTIES, AND APPLICATIONS (1960)

CONTENTS I. Introduction 509 II. The structure and composition of zeolites. Classification 510 III. The preparation of synthetic zeolites 512 IV. The sorptive properties of zeolites 514 V. The separation of mixtures by molecular sieves 517 VI. Methods of altering the selectivity of zeolites 518 VI. Possible technical applications of molecular sieve 519
Selective decay for the rotating shallow-water equations with a structure-preserving discretization (2021)

Numerical models of weather and climate critically depend on the long-term stability of integrators for systems of hyperbolic conservation laws. While such stability is often obtained from (physical or numerical) dissipation terms, physical fidelity of such simulations also depends on properly preserving conserved quantities, such as energy, of the system. To address this apparent paradox, we develop a variational integrator for the shallow water equations that conserves energy but dissipates potential enstrophy. Our approach follows the continuous selective decay framework [F. Gay-Balmaz and D. Holm. Selective decay by Casimir dissipation in inviscid fluids. Nonlinearity, 26(2), 495 (2013)], which enables dissipating an otherwise conserved quantity while conserving the total energy. We use this in combination with the variational discretization method [Pavlov et al., “Structure-preserving discretization of incompressible fluids,” Physica D 240(6), 443–458 (2011)] to obtain a discrete selective decay framework. This is applied to the shallow water equations, both in the plane and on the sphere, to dissipate the potential enstrophy. The resulting scheme significantly improves the quality of the approximate solutions, enabling long-term integrations to be carried out.
Biomedical Applications of Polyurethanes: Implications of Failure Mechanisms (1988)

Three mechanisms have been described which explain various observed interactions between polyurethane chemistry and body chemistry. These include calcification, environmental stress cracking, and chain scission. Each may result in implant device failure, and each appears to involve metal ion complexation as a key parameter. Continued expansion of polyurethane into implantable product applications will require further clarification of the effect of each of these interactions on long-term product performance. It is believed that design considerations and polymer modifications will help control the effects of each of the interactions and will result in new and improved polyurethane implant products.
Lensless close-up imaging with Fresnel zone aperture (2018)

Lensless light-field imaging technology using a Fresnel zone aperture (FZA) enables the development of extremely thin cameras with a function of refocusing after image capture. We propose two close-up technologies for lensless technology to image objects at short distances of millimeter order: fringe scan and fly-eye FZA technologies. Our fringe scan technology successfully cancels an artifact appearing at distances of millimeter order between an object and the FZA. Our fly-eye FZA technology expands the narrow field of view caused by the characteristics of the chief ray angle of image sensors. Our experimental results indicate that these technologies enable us to capture images of objects set 2 mm from the FZA. Our close-up technologies can expand the application scope of lensless technology, such as for inspection tools in limited spaces by taking advantage of the small tool size.
The Effect of Food on Cysteamine Bitartrate Absorption in Healthy Participants (2012)

Cysteamine absorption may be decreased by 30% when taken with food as compared with the fasting state. Food causes wide variation in tmax and Cmax for cysteamine.
Human interferon alpha A or alpha D and trifluridine treatment for herpetic keratitis in rabbits. (1984)

Recombinant human interferon (IFN) alpha A and alpha D combined with 1% trifluridine ophthalmic solution gave beneficial results when applied topically at a dose of 1 x 10(6) U per eye four times a day commencing 4 hr after eyes were inoculated with herpes simplex virus (HSV-1). Acute herpetic keratitis was suppressed by trifluridine alone and the combined therapies, but the high-titered interferon preparations, alone, had little effect. Duration of HSV-1 shedding into tear film during topical treatment for acute herpetic keratitis was reduced slightly by combined therapy with either IFN alpha A or IFN alpha D with trifluridine.
Low-Temperature Removal of H2S by Nanoporous Composite of Polymer−Mesoporous Molecular Sieve MCM-41 as Adsorbent for Fuel Cell Applications (2005)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTLow-Temperature Removal of H2S by Nanoporous Composite of Polymer−Mesoporous Molecular Sieve MCM-41 as Adsorbent for Fuel Cell ApplicationsXiaochun Xu, Ivan Novochinskii, and Chunshan SongView Author Information Clean Fuels and Catalysis Program, The Energy Institute, and Department of Energy and Geo-Environmental Engineering, Pennsylvania State University, 209 Academic Projects Building, University Park, Pennsylvania 16802 Cite this: Energy Fuels 2005, 19, 5, 2214–2215Publication Date (Web):August 6, 2005Publication History Received12 March 2005Revised7 July 2005Published online6 August 2005Published inissue 1 September 2005https://pubs.acs.org/doi/10.1021/ef050061ohttps://doi.org/10.1021/ef050061orapid-communicationACS PublicationsCopyright © 2005 American Chemical SocietyRequest reuse permissionsArticle Views743Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Adsorption,Nanoparticles,Oxides,Polyethylenimine,Sulfur Get e-Alerts
The wound infection continuum and its application to clinical practice. (2003)

Four basic conditions exist in open wounds resulting from the level of bioburden present (bacterial contamination--normal but short-lived state, colonization--normal state, critical colonization--abnormal state, and infection--abnormal state). The two abnormal states have the potential to disrupt the orderly healing sequence, which results in the development of a chronic wound. In addition, the impact of the wound s anatomical position, duration, shape, or presentation; the patient s level of health and control of underlying pathologies; the presence of infection-potentiating factors such as foreign bodies, hematoma, and necrotic tissue; the sources and frequency of exogenous contamination; the considered virulence of the individual micro-flora species; and the potential synergism between different species all require consideration. This article discusses the states of bioburden and other aspects of microbiology relating to wound infection and their application to clinical practice.
ChemInform Abstract: IBX‐Mediated Oxidation of Unactivated Cyclic Amines: Application in Highly Diastereoselective Oxidative Ugi‐Type and Aza‐Friedel—Crafts Reactions. (2016)

ChemInformVolume 47, Issue 7 Preparative Organic Chemistry ChemInform Abstract: IBX-Mediated Oxidation of Unactivated Cyclic Amines: Application in Highly Diastereoselective Oxidative Ugi-Type and Aza-Friedel—Crafts Reactions. C. de Graaff, C. de Graaff Dep. Chem. Pharm. Sci., Vrije Univ., NL-1081 HV Amsterdam, Neth.Search for more papers by this authorL. Bensch, L. Bensch Dep. Chem. Pharm. Sci., Vrije Univ., NL-1081 HV Amsterdam, Neth.Search for more papers by this authorMatthijs J. van Lint, Matthijs J. van Lint Dep. Chem. Pharm. Sci., Vrije Univ., NL-1081 HV Amsterdam, Neth.Search for more papers by this authorE. Ruijter, E. Ruijter Dep. Chem. Pharm. Sci., Vrije Univ., NL-1081 HV Amsterdam, Neth.Search for more papers by this authorR. V. A. Orru, R. V. A. Orru Dep. Chem. Pharm. Sci., Vrije Univ., NL-1081 HV Amsterdam, Neth.Search for more papers by this author C. de Graaff, C. de Graaff Dep. Chem. Pharm. Sci., Vrije Univ., NL-1081 HV Amsterdam, Neth.Search for more papers by this authorL. Bensch, L. Bensch Dep. Chem. Pharm. Sci., Vrije Univ., NL-1081 HV Amsterdam, Neth.Search for more papers by this authorMatthijs J. van Lint, Matthijs J. van Lint Dep. Chem. Pharm. Sci., Vrije Univ., NL-1081 HV Amsterdam, Neth.Search for more papers by this authorE. Ruijter, E. Ruijter Dep. Chem. Pharm. Sci., Vrije Univ., NL-1081 HV Amsterdam, Neth.Search for more papers by this authorR. V. A. Orru, R. V. A. Orru Dep. Chem. Pharm. Sci., Vrije Univ., NL-1081 HV Amsterdam, Neth.Search for more papers by this author First published: 28 January 2016 https://doi.org/10.1002/chin.201607039Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume47, Issue7January, 2016 RelatedInformation
Interrater reliability of sleep videofluoroscopy for airway obstruction in obstructive sleep apnea (2013)

This study showed that SVF was a diagnostic modality that can be used to evaluate upper airway obstruction without significant interrater disagreements.
True median palatal cyst; a rare case report (2018)

Median palatal cyst is rare nonodontogenic lesion as it represents only 7.14% of all jaw cysts. Also called mid palatal cyst has raised controversy about pathogenesis of such fissural cysts. Specific diagnostic criteria have been described for true median palatal cyst after it has been excluded from WHO classification. The purpose of this paper is to report a rare case of true median palatal cyst satisfying these criteria and discuss current controversy about these cysts.
An improved high-voltage waveform generator (1983)

An improved high-voltage low-frequency waveform generator is described. It is based on a design by Miller et al. (1975) with the addition of a feedback control loop. The device can supply up to 27 kV and 2 mA from 0-100 Hz, and up to 10 kV at 1 kHz. Total harmonic distortion is reduced from the earlier device to under 1%, and phase response (under 1 mradian lag at 1 kHz) is good enough for straightforward use in three-phase circuits. Components are inexpensive, with widely available high-voltage triodes used in the output stage. A fibre-optic link isolates the high-voltage sections from the low-voltage control network.
Serological pattern ‘anti-hepatitis B core alone’ in HIV or hepatitis C virus-infected patients is not fully explained by hepatitis B surface antigen mutants (2004)

We determined the frequency of hepatitis B virus (HBV) occult infection and studied S gene mutations in HIV or hepatitis C virus-co-infected patients with persistent pattern 'anti-hepatitis B core alone'. HBV DNA was particularly frequent in HIV-positive patients. Sequencing of the S gene showed that only two HIV-infected patients harboured mutants in the major hydrophilic loop; the absence of hepatitis B surface antigen detection could not be explained by diagnostic escape mutants.
Incorporation of the 1‐pro‐R and the 1‐pro‐S Hydrogen Atoms of Ethanol into Steroids and Phosphatidylcholines in vivo (1977)

The transfer of deuterium from chiral 1-monodeuteroethanols to various metabolites formed in the liver was studied in order to investigate the coupling of metabolic reductions to the alcohol dehydrogenase and the aldehyde dehydrogenase reactions. The ethanols were administered to female bile fistula rats for 10 h. The hydrogen at C-2 in the glycerol moiety of newly formed phosphatidylcholine molecules in bile, liver and plasma was derived to 22-25% from the 1-pro-R position and to 5-6% from the 1-pro-S position in the ethanol. sn-Glycerol 3-phosphate isolated from liver had a lower deuterium content at C-2. The ratio between the contributions from the two positions in ethanol to C-2 of free sn-glycerol 3-phosphate was the same as in the phosphatidylcholines. This indicates that the higher degree of labelling of this position in phosphatidylcholines is not due to a specific coupling between alcohol dehydrogenase and the formation of a phosphatidylcholine precursor. Cholesterol and chenodeoxycholic acid in bile became increasingly labelled, and the ratio between the incorporations from the 1-pro-S and the 1-pro-R positions of ethanol was about 0.37 in cholesterol and 0.46 in chenodeoxycholic acid. Thus, these NADPH-dependent reactions utilized hydrogen from the 1-pro-S position to a larger extent than NADH-dependent reactions.
Double-Zipper: Multiple Access with ZigZag Decoding (2020)

As a building block toward a simple and scalable solution to massive random access, we consider two-user multiple access with ZigZag decoding, with no need for any coordination or codebook differentiation. We derive closed-form bounds on the achievable sum-rates of the original ZigZag and a modified version of it, called double-zipper ZigZag, for both cases of perfect and imperfect channel state information (CSI). We also show that performances of both versions of ZigZag approach that of optimal coordinated time-sharing in the high signal to noise ratio regime, even in the presence of CSI errors.
Pituitary adenylate cyclase activating peptide (PACAP) affects homeostatic sleep regulation in healthy young men (2007)

Pituitary adenylate cyclase activating peptide (PACAP) is involved in autonomous regulation by its action on the suprachiasmatic nucleus (SCN) and on neuroendocrine secretion. In rats PACAP promotes REM sleep. We investigated the effect of PACAP on human sleep. 4×12.5µg PACAP-38 or placebo were given hourly between 2200 and 0100 to young normal males. Sleep EEG was recorded from 2300 to 1000. Blood samples were collected simultaneously for the determination of ACTH, cortisol, growth hormone and prolactin. EEG spectral analysis revealed a significant reduction in the theta-frequency range in the first 4 hour interval of NonREM sleep and of the lower spindle frequency range in the second 4 hour interval of the registration period. This was accompanied by a reduction of the physiological delta-power decline during the night, i.e. an increase in the related time constant T from 339±75min after placebo to 558±326min after PACAP (p<0.05). As with SWS there is a reduced delta power accumulation in the early part of the registration period, whereas in the later intervals the cumulative SWS runs in parallel after PACAP and after placebo pointing to a reduced SWS need after PACAP administration. Furthermore a trend to a decreased prolactin secretion in the first 4 hour period of the night was found. No other endocrine changes were observed. In conclusion PACAP leads to a reduction of the dynamic of homeostatic sleep regulation and prolactin secretion.