gebhart/patrepeval huggingface dataset:
Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair element. (1987)

cAMP regulates transcription of the gene encoding the alpha-subunit of human chorionic gonadotropin (hCG) in choriocarcinoma cells (BeWo). To define the sequences required for regulation by cAMP, we inserted fragments from the 5' flanking region of the alpha-subunit gene into a test vector containing the simian virus 40 early promoter (devoid of its enhancer) linked to the bacterial chloramphenicol acetyltransferase (CAT) gene. Results from transient expression assays in BeWo cells indicated that a 1500-base-pair (bp) fragment conferred cAMP responsiveness on the CAT gene regardless of position or orientation of the insert relative to the viral promoter. A subfragment extending from position -169 to position -100 had the same effect on cAMP-induced expression. Furthermore, the entire stimulatory effect could be achieved with an 18-bp synthetic oligodeoxynucleotide corresponding to a direct repeat between positions -146 and -111. In the absence of cAMP, the alpha-subunit 5' flanking sequence also enhanced transcription from the simian virus 40 early promoter. We localized this enhancer activity to the same -169/-100 fragment containing the cAMP response element. The 18-bp element alone, however, had no effect on basal expression. Thus, this short DNA sequence serves as a cAMP response element and also functions independently of other promoter-regulatory elements located in the 5' flanking sequence of the alpha-subunit gene.
Processing of polyurethane/polyester interpenetrating polymer networks by reaction injection molding (RIM). Part I: Design of a high pressure RIM system (1986)

Abstract This is the first of a three‐part paper investigating the feasibility of processing polyurethane/polyester Interpenetrating Polymer Networks (IPN) by Reaction Injection Molding (RIM). The fundamental mixing process is discussed. Various approaches reported to analyze mixing are also critically reviewed. Good part quality in RIM mixing activated systems suggests the need for the creation of a rapid and intense turbulent state within the small impingement chamber. In order to generate the conditions of reactive components intermingling down to submicron dimensions, a high pressure RIM unit was built and tested. The device can inject reactants at high stream Reynolds numbers (around 10,000) and impingement pressures (up to 100,000 psi, 6,895 bar.).
Rotating laminar emission camera with GE‐detector: Experimental results (1981)

Experimental results of a prototype rotating laminar emission camera (ROLEC) for nuclear medicine imaging are reported. A 11.5 mm thick, 45 x 45 mm high-purity germanium detector is segmented into 30 1.47 mm wide parallel channels and collimated with 39 mm high parallel plates. Projection data acquired at multiple angular orientations as the detector-collimator assembly is rotated about its center are mathematically reconstructed to image the activity distribution. The spatial resolution of the ROLEC is at least twice as good, at all distances, as that of gamma cameras with high resolution collimators. The better energy resolution of the germanium enhances the detection and resolution of the ROLEC in comparison to gamma cameras with NaI(T1) crystals, the relative superiority increasing with greater volumes and with greater depths. Adequate sensitivity is maintained while achieving these improvements in spatial resolution and in practice; ROLEC images are acquired in less time than pinhole collimator images with gamma cameras.
The β1 and β3 Integrins Promote T Cell Receptor-mediated Cytotoxic T Lymphocyte Activation (2003)

Recognition by CD8+ cytotoxic T lymphocytes (CTLs) of antigenic peptides bound to major histocompatibility class (MHC) I molecules on target cells leads to sustained calcium mobilization and CTL degranulation resulting in perforin-dependent killing. We report that beta1 and beta3 integrin-mediated adhesion to extracellular matrix proteins on target cells and/or surfaces dramatically promotes CTL degranulation. CTLs, when adhered to fibronectin but not CTL in suspension, efficiently degranulate upon exposure to soluble MHC.peptide complexes, even monomeric ones. This adhesion induces recruitment and activation of the focal adhesion kinase Pyk2, the cytoskeleton linker paxillin, and the Src kinases Lck and Fyn in the contact site. The T cell receptor, by association with Pyk2, becomes part of this adhesion-induced activation cluster, which greatly increases its signaling.
Novel [2 + 2 + 2]Annulation of 1,6-Diynes Mediated by Methallylchromate or Methallylmagnesium Chloride under CrCl3Catalysis (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTNovel [2 + 2 + 2]Annulation of 1,6-Diynes Mediated by Methallylchromate or Methallylmagnesium Chloride under CrCl3 CatalysisToshihiro Nishikawa, Hirotada Kakiya, Hiroshi Shinokubo, and Koichiro OshimaView Author Information Department of Material Chemistry Graduate School of Engineering Kyoto University, Kyoto 606-8501, Japan Cite this: J. Am. Chem. Soc. 2001, 123, 19, 4629–4630Publication Date (Web):April 19, 2001Publication History Received2 March 2001Revised2 April 2001Published online19 April 2001Published inissue 1 May 2001https://doi.org/10.1021/ja015746rCopyright © 2001 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views604Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (39 KB) Get e-AlertsSupporting Info (3)»Supporting Information Supporting Information SUBJECTS:Anions,Annulations,Chemical reactions,Chromium,Reagents Get e-Alerts
A time series data management framework (2005)

In the real world there are thousands of time series data that coexists with other data. Every day tons of data is collected in the form of time series. Time series is a collection of observations that is recorded or measured over time on a regular or irregular basis generally sequentially. Time series arise in financial, economic, and scientific applications. Typical examples are the recording of different values of stock prices, bank transactions, consumer price index, electricity and telecommunication data, etc. In theory, such data is processed, analyzed, disseminated, and presented. However, many institutions are facing some difficult issues in organizing such a vast amount of data. Therefore, the need for data management tools has become more and more important. This paper addresses this issue by proposing a framework for Time Series Data Management (TSDM). The central abstraction for the proposed domain specific framework is the notion of Business Sections, Group of Time Series, and Time Series itself. The framework integrates minimum specification regarding structural and functional aspects for time series data management.
Donor-derived duodenal adenocarcinoma of a bladder-drained pancreas allograft (2022)

The subset of the population that received bladder-drained allograft pancreata during peak utilization of the technique in the 1990s is approaching 20-30 postoperative years. This time frame is salient, as it parallels the time in which patients in the urologic literature develop adenocarcinomas after bladder reconstruction using gastrointestinal segments. We present the case of a 57-year-old simultaneous pancreas/kidney recipient who presented with microhematuria twenty-four years after transplantation and was found to have an adenocarcinoma of the duodenum of his failed, bladder-drained pancreas. After allograft pancreatectomy/duodenectomy, he remains disease-free eleven months postoperatively. As this patient population ages, practitioners should consider pathology of the donor duodenum and pancreas in recipients who present with gross or microscopic hematuria.
Inorganic nanoparticles engineered to attack bacteria (2015)

Antibiotics were once the golden bullet to constrain infectious bacteria. However, the rapid and continuing emergence of antibiotic resistance (AR) among infectious microbial pathogens has questioned the future utility of antibiotics. This dilemma has recently fueled the marriage of the disparate fields of nanochemistry and antibiotics. Nanoparticles and other types of nanomaterials have been extensively developed for drug delivery to eukaryotic cells. However, bacteria have very different cellular architectures than eukaryotic cells. This review addresses the chemistry of nanoparticle-based antibiotic carriers, and how their technical capabilities are now being re-engineered to attack, kill, but also non-lethally manipulate the physiologies of bacteria. This review also discusses the surface functionalization of inorganic nanoparticles with small ligand molecules, polymers, and charged moieties to achieve drug loading and controllable release.
Smart Moves: Intelligent Pathfinding (1998)

PathDemo (Oct'96 Archive) [Get Demo] Of all the decisions involved in computer-game AI, the most common is probably pathfinding -looking for a good route for moving an entity from here to there. The entity can be a single person, a vehicle, or a combat unit; the genre can be an action game, a simulator, a role-playing game, or a strategy game. But any game in which the computer is responsible for moving things around has to solve the pathfinding problem.
Fabrication Of Aspheric Germanium-Lens Surfaces By Ion Milling (1986)

Ion milling was studied as a method for removing a well defined amount of material from a spherically shaped surface to fabricate high quality aspheric germanium lenses. The ion-current density of the beam was determined as a function of the acceleration voltage and argon-gas flow in order to find near optimum conditions for smooth etching of the lens surface. The sputtering yield was studied as a function of the angle of incidence of the beam with respect to the target surface. Based upon these data, a computer program was designed, which controls the dwell time and the corresponding position of the lens with respect to the ion beam such as to generate a prescribed surface shape.
Olefin terpolymerizations. I. 1,4‐hexadiene (1995)

Abstract Ethylene (E), propylene (P), and 1,4‐hexadiene (HD) were terpolymerized with rac ‐1,2‐ethylenebis (1‐η 5 ‐indenyl) zirconium(IV) dichloride and methylaluminoxane (Et[Ind] 2 ZrCl 2 /MAO), and compared with the copolymerizations of E/P, E/HD, P/HD, and terpolymerization using ethylidene norbornene (ENB) as the termonomer. HD lowers the polymerization activity, the effect is more pronounced for P/HD and E/P/HD using large amount of P, than for E/HD and E/P/HD using feed low in P. The polymer molecular weight is most strongly affected by the temperature of polymerization ( T p ), whereas the E/P ratio in the feed has virtually no effect. The reactivity ratios r E and r P are 3.0 and 0.3, respectively, at 20°C but r P becomes larger than r E at T P = 70°C. 1 H‐NMR spectra showed occurrence of cycloaddition in the homopolymerization of HD; on the other hand, HD is incorporated in the terpolymer only by linear 1,2‐addition. © 1995 John Wiley &amp; Sons, Inc.
Kinetics of defibrillation shock-induced response: design implications for the optimal defibrillation waveform (2002)

The time constant of the membrane depends on the field, action potential phase and the shock polarity, but exceeds 1 msec. Therefore, we suggest using a slower shock leading edge, since the membrane cannot follow potentially damaging faster waveforms.
Optimization approach for the combined planning and control of an agile assembly system for electric vehicles (2020)

For some years now, the automotive industry has been challenged by growing market dynamics, shorter product lifecycles and customers' increasing demands for individualization. In order to cope with this development, the automotive assembly needs to adapt quickly to changing demands with a low level of investment in the future. Under the current circumstances, the traditional line assembly for high volume production is reaching its limits in terms of adaptability and scalability. A promising solution to address the current challenges is the concept of the agile assembly. The concept of agile assembly breaks up the rigid linkage of assembly stations and, thus, enables full flexibility in the sequence of assembly operations only limited by the precedence graph. Therefore, the routing of electric vehicles in the agile assembly is based on the availability of resources such as assembly stations and automated guided vehicles that handle the material supply. Further, by transferring the transport function to the vehicle itself, investments for convey or systems are eliminated. This research work presents an optimization approach for the machine scheduling and transportation planning, which derives instructions for electric vehicles, assembly stations as well as automated guided vehicles. For each electric vehicle, an optimized route is calculated, taking into account product-specific precedence graphs and minimizing the overall makespan. In addition, the machine scheduling and transportation planning is integrated into a combined planning and control concept which covers the allocation of resources and the assignment of capabilities of the entire assembly system. The approach is implemented and applied to a practical case of a compact electric vehicle. Thus, the work contributes to the evaluation of agile assembly systems in automotive production.
A Host Based Method for Data Leak Protection by Tracking Sensitive Data Flow (2012)

This paper describes a method for data leak protection (DLP) based on tracking sensitive information as it flows inside file system on a host. The method is based on the idea that every flow from sensitive to non-sensitive object increases the security level of the target object to that of the source object. Any process which reads an object that contains sensitive data automatically itself becomes tagged as sensitive. When a process gets tagged, all subsequent write operations to any object make target objects also tagged. Any process created by a tagged process is also tagged. By spreading tags over all objects touched by a sensitive process, we have a guarantee that no one bit of sensitive information resides in a non-sensitive objects. Using any software tool to process a sensitive object results in a new sensitive object, this prevents bypassing security mechanisms. All objects tagged as sensitive are checked before being transferred out of the host according to security policy. The main goal of this method is to prevent covert channels for information leakage which use steganography, data modification, compression or encryption. It is implemented in Linux OS as a kernel module. It works with legacy applications, since all changes are on OS level.
Mechanism of cross-link formation in a solid photopolymer based on the chromophore 1,2-diphenylcyclopropene (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of cross-link formation in a solid photopolymer based on the chromophore 1,2-diphenylcyclopropeneM. V. Mijovic, P. J. Beynon, T. J. Shaw, K. Petrak, A. Reiser, A. J. Roberts, and D. PhillipsCite this: Macromolecules 1982, 15, 6, 1464–1471Publication Date (Print):November 1, 1982Publication History Published online1 May 2002Published inissue 1 November 1982https://pubs.acs.org/doi/10.1021/ma00234a003https://doi.org/10.1021/ma00234a003research-articleACS PublicationsRequest reuse permissionsArticle Views77Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Towards industrially applicable modeling technique for agent-based systems (2002)

No abstract available.
CuTe Nanocrystals: Shape and Size Control, Plasmonic Properties, and Use as SERS Probes and Photothermal Agents (2013)

We report a procedure to prepare highly monodisperse copper telluride nanocubes, nanoplates, and nanorods. The procedure is based on the reaction of a copper salt with trioctylphosphine telluride in the presence of lithium bis(trimethylsilyl)amide and oleylamine. CuTe nanocrystals display a strong near-infrared optical absorption associated with localized surface plasmon resonances. We exploit this plasmon resonance for the design of surface-enhanced Raman scattering sensors for unconventional optical probes. Furthermore, we also report here our preliminary analysis of the use of CuTe nanocrystals as cytotoxic and photothermal agents.
Kerbformoptimierung ohne FEM: Ein einfacher Weg, um Kerbspannungen abzubauen (2003)

Abstract Eine analytische Vorgehensweise zur Bauteiloptimierung wird vorgestellt, die ohne FEM‐Einsatz auskommt. Es ergeben sich deutliche Kerbspannungsreduktionen bei minimalem Aufwand.
Atlas de Barrios Vulnerables de España: 12 Ciudades 1991/2001/ 2006 (2015)

El Altas de Barrios Vulnerables de Espana se basa en los trabajos recogidos en los catalogos “Analisis urbanistico de Barrios Vulnerables” de 1991 y 2001, y su Adenda 2006, realizados gracias al convenio de colaboracion entre la Seccion de Urbanismo del Instituto Juan de Herrera de la Universidad Politecnica de Madrid (UPM) y el Ministerio
de Fomento.
En este documento no se recogen los catalogos de los barrios estudiados, que pueden ser consultados on-line, ya que el objetivo es presentar un panorama general sobre la dimension y evolucion de la vulnerabilidad de las ciudades espanolas de mas de 50.000 habitantes. El marco general se completa con los informes individuales de las 12 ciudades de mas de 300.000 habitantes. Los informes individuales contienen el analisis estadistico de la evolucion de la vulnerabilidad de cada una de las ciudades con un especial cuidado en su representacion cartografica, que permite al lector un analisis territorial de la vulnerabilidad urbana y la comparacion tanto temporal como por tipo de vulnerabilidad.
Ademas, para facilitar la comprension de los datos analizados, este Atlas se acompana de un conjunto de anexos en los que se describe la metodologia empleada en el trabajo del que se extraen dicho datos, y un glosario de terminos basicos para su comprension.
Process-Based Costing (2003)

Understanding how quality improvement affects costs is important. Unfortunately, low-cost, reliable ways of measuring direct costs are scarce. This article builds on the principles of process improvement to develop a costing strategy that meets both criteria. Process-based costing has 4 steps: developing a flowchart, estimating resource use, valuing resources, and calculating direct costs. To illustrate the technique, this article uses it to cost the care planning process in 3 long-term care facilities. We conclude that process-based costing is easy to implement; generates reliable, valid data; and allows nursing managers to assess the costs of new or modified processes.
Bovine Somatic Cell Nuclear Transfer Using Recipient Oocytes Recovered by Ovum Pick-Up: Effect of Maternal Lineage of Oocyte Donors1 (2002)

The efficiency of bovine nuclear transfer using recipient oocytes recovered by ultrasound-guided follicle aspiration (ovum pick-up [OPU]) was investigated. Oocyte donors were selected from 2 distinct maternal lineages (A and B) differing in 11 nucleotide positions of the mitochondrial DNA control region. A total of 1342 cumulus-oocyte complexes (COCs) were recovered. The numbers of total COCs and class I/II COCs recovered from donors of lineage A were higher (P < 0.001) than those obtained from lineage B. Follicle aspiration once per week yielded a higher (P < 0.001) total number of COCs per session than aspiration twice per week, whereas the reproduction status of donors (heifer vs. cow) had no effect on OPU results. Of the 1342 oocytes recovered, 733 (55%) were successfully matured in vitro and used for nuclear transfer. Fusion was achieved in 550 (75%) karyoplast-cytoplast complexes (KCCs), resulting in 277 (50%) cleaved embryos on Day 3. On Day 7 of culture, 84 transferable embryos (15% based on fused KCCs) were obtained. After 38 transfers (10 single, 22 double, and 6 triple transfers), 9 recipients (8 double and 1 triple transfer) were diagnosed as pregnant on Day 28, corresponding to a pregnancy rate of 24%. The proportion of transferable embryos on Day 7 was significantly (P < 0.05) influenced by maternal lineage of oocyte donors and by the frequency of follicle aspiration. Our study demonstrates the feasibility of generating nuclear transfer embryos with defined cytoplasmic background. These will be valuable tools to experimentally dissect the effects of nuclear and cytoplasmic components on embryonic, fetal, and postnatal development.
Effects of MK-0941, a Novel Glucokinase Activator, on Glycemic Control in Insulin-Treated Patients With Type 2 Diabetes (2011)

In patients receiving stable-dose insulin glargine, the GKA MK-0941 led to improvements in glycemic control that were not sustained. MK-0941 was associated with an increased incidence of hypoglycemia and elevations in triglycerides and blood pressure.
A genetic algorithm for joint optimization of capacity and flow assignment in packet switched networks (2002)

One of the design problems concerning packet switched computer communication networks is the joint optimization of capacity and flow assignment (CFA). In this problem the topology of the network and the traffic requirements between node pairs are given, and the objective is to find the flows on the different links and their capacities that minimize the total network cost and keep its average delay below a certain upper limit. This paper proposes an algorithm based on hybridization of genetic algorithms (GA) and the shortest path routing. The proposed algorithm has shown simplification in implementation and improvement in performance. Computational results indicated a 3.17% reduction in network cost when compared with a previous method.
Intradermal Hepatitis B Vaccine: Pilot study. (1992)

Intramuscular administration of hepatitis B (HB) vaccine is safe and efficacious, but its cost has limited its availability. In this pilot study, 49 of 56 participants who received 2 μg of intradermal (ID) HB vaccine (one tenth the intramuscular dose) at the beginning of administration, at 1 month, and at 6 months developed protective levels of antibody to HB surface antigen. Although questions remain, the cost savings of this technique make it worth considering.
Summary Abstract: Formamide adsorption at 80 K on clean and chemically modified Ru(001) surfaces (1988)

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