gebhart/patrepeval huggingface dataset:
[Laparoscopic cholecystectomy in antegrade (prograde) technique]. (1997)

In the case of acute cholecystitis and chronic cholecystitis of lang standing, the inflammatory changes in Calot's triangle make the risk of damaging the bile duct during laparoscopic cholecystectomy particularly high. In view of the difficult anatomical situation in Calot's triangle, such patho-anatomical conditions when encountered during open surgery best dealt with by anterograde (prograde) dissection of the gallbladder beginning from the fundus and proceeding towards the neck of the gallbladder. Since this approach is considered to be safer and less risky, it should also be adopted during laparoscopic surgery. The advantage is to be seen in the initial dissection far removed from the bile ducts. Despite pronounced inflammatory changes and initial preservation of the cystic artery, the use of modern technologies permit a virtually bloodless procedure. Nevertheless, the difficult anatomical situation makes a high level of readiness to conver mandatory. Should there be any doubt, the open surgical approach is the safer modality.
A method for the end-to-end testing of VoIP service networks (2004)

While methods of end-to-end testing for the PSTN (public switched telephone network) are well-established, this is not the case for VoIP (voice-over-IP) networks. In a VoIP network where the carrier is large-scale (numbers of network elements and sites are large), we should be able to realize end-to-end testing mainly by combining commercial products, such as monitoring tools and test-call generators. We propose a system for the end-to-end testing of networks at the carrier level, clarify the technical elements that the system will require and conditions that apply, and describe a suitable software structure.
Advanced Technologies in the Radiotherapy Clinic: System Fundamentals (2011)

The radiotherapy treatment process is undergoing rapid development at every step from planning through delivery, and each step is increasingly automated and assisted by new imaging, positioning, contouring and treatment tools. Plan delivery and verification is now aided using an increasing range of image guidance technologies, and imaging at treatment now brings broad opportunities for dose guidance and adaptation for improving overall treatment quality. While these many tools bring exciting opportunities for exact, reliable and efficient targeting of radiation dose, a consistently high level of accuracy must be achieved at every step to achieve the desired results. This level of workmanship requires thorough understanding of the basic methods involved in each step, including the opportunities and limitations, by both the clinicians and the planning/delivery staff alike. These processes and their clinical implementation are discussed in depth throughout this volume. Here, we overview their integration and guiding background concepts, as well as a range of workday efficiencies for clinical practice.
The crystal structure of Pb7FeIIFe6IIIF34: A new jarlite‐type compound (1996)

Abstract Pb 7 Fe II Fe F 34 is monoclinic: a = 16.375(2) Å, b = 11.233(2) Å, c = 7.615(1) Å, β = 102.67(1)º, Z = 2. The crystal structure was solved in the space group C2/m (nº 12), from X‐ray single crystal data using 957 independent reflections (705 with F/σ(F) &gt; 4, leading to R = 0.038). It consists in infinite helicoidal [Fe II Fe F 34 ] n 14n− double‐chains of cornersharing octahedra running along the b ‐axis and separated from each other by lead ions.
Periodic Metallic Nanostructures as Plasmonic Chemical Sensors (2013)

Periodic plasmonic nanostructures are being widely studied, optimized, and developed to produce a new generation of low-cost and efficient chemical sensors and biosensors. The extensive variety of nanostructures, interrogation approaches, and setups makes a direct comparison of the reported performance from different sensing platforms a challenging exercise. In this feature Article, the most common parameters used for the evaluation of plasmonic nanostructures will be reviewed, with particular focus on the advances in periodic plasmonic nanostructures. Recent progress in the fabrication methods that allow for the high-volume production of periodic plasmonic sensors at low cost will be described, together with an assessment of the state of the art in terms of periodic structures employed for chemical sensing.
Spatial resolution properties of penalized-likelihood image reconstruction: Space-invariant tomographs (2005)

This paper examines the spatial resolution properties of penalized-likelihood image reconstruction methods by analyzing the local impulse response. The analysis shows that standard regularization penalties induce space-variant local impulse response functions, even for space-invariant tomographic systems. Paradoxically, for emission image reconstruction, the local resolution is generally poorest in high-count penalties depends on the object only through its projections. This analysis leads naturally to a modified regularization penalty that leads naturally to a modified regularization penalty that yields reconstructed images with nearly uniform resolution. The modified penalty also provides a very practical method for choosing the regularization parameter to obtain a specified resolution in images reconstructed by penalized-likelihood methods.
Off-label applications for SSRIs. (2003)

Selective serotonin reuptake inhibitors (SSRIs) are widely used because of their safety, tolerability, and demonstrated efficacy across a broad range of clinical conditions. Medical literature supports the use of SSRIs for the treatment of many conditions outside of the indications approved by the U.S. Food and Drug Administration. SSRIs offer a reasonable alternative to traditional therapy for generalized anxiety disorder. A side effect of SSRIs coincidentally provides therapy for premature ejaculation. SSRIs may reduce the frequency and severity of migraine headaches and are possibly effective in reducing the pain of diabetic neuropathy. When taken in combination with tricyclic antidepressants, SSRis offer more potent therapy for fibromyalgia than either agent alone. SSRIs appear to be effective in some patients with neurocardiogenic syncope that is refractory to standard therapies. Clinical experience supported by ongoing research continues to expand on the broad array of therapeutic applications for this class of medication.
Selection of RNA Oligonucleotides That Can Modulate Human Dicer Activity In Vitro (2011)

Human ribonuclease Dicer is an enzyme that excises small regulatory RNAs from perfectly or partially double-stranded RNA precursors. Although Dicer substrates and products have already been quite well characterized, our knowledge about cellular factors regulating the activity of this enzyme is still limited. To learn more about this problem, we attempted to determine whether RNA could function not only as a Dicer substrate but also as its regulator. To this end, we applied an in vitro selection method. We identified 120 RNA oligomers binding human Dicer. Sixteen of them were subjected to more detailed in vitro studies. We found that 6 out of 16 oligomers affected Dicer ability to digest pre-microRNAs (miRNAs), although most of them were cleaved by this enzyme. For the 6 most active oligomers the putative mechanism of Dicer inhibition was determined. Three oligomers were classified as typical competitive inhibitors and one as an allosteric inhibitor. The remaining 2 oligomers acted as selective inhibitors. They affected the production of 1 miRNA, whereas the formation of other miRNAs was hardly influenced. In general, the data obtained suggest that one can modulate the generation of specific miRNAs by using RNA oligomers. Moreover, we found that sequences similar to those of the selected oligomers can be found within the molecules composing human transcriptome.
An optimized multicore cache coherence design for exploiting communication locality (2012)

Supporting cache coherence in current multicore processor still faces scalability and performance problems. This paper presents an optimized cache coherence design targeting at NoC-based multicore processors. It tries to achieve the best characteristics both of the snooping and of the directory-based protocols. With the observation of network traffic locality, we design a cache coherence that aims at local and remote access separately. At the first level, snooping is achieved within a cache group and at the second level of the protocol, the coarse directories provide the caches with information about which processors must be involved in first level snooping. To support efficient coherence broadcasting, we also propose a low latency, broadcast-enabled underlying NoC design. It incorporates light weight buses into NoCs, where the snooping protocol can be performed in a broadcast fashion. Extensive experimental results demonstrate that the proposed coherence design can achieve low complexity and high performance goals.
Hough transform network: learning conoidal structures in a connectionist framework (2002)

A two-layer neural-network model is designed which accepts image coordinates as the input and learns the parametric form of conoidal shapes (lines/circles/ellipses) adaptively. It provides an efficient representation of visual information embedded in the connection weights and the parameters of the processing elements. It not only reduces the large space requirements of the classical Hough transform (HT), but also represents parameters with a higher precision. The performance of the methodology is compared with other existing algorithms and has been found to excel over those algorithms in many cases.
Desmoplastic stroma and cholangiocarcinoma: Clinical implications and therapeutic targeting (2013)

holangiocarcinomas are usually characterized by a prominent desmoplastic and hypovascularized stroma. However, the biological significance and clinical impact of the desmoplastic stroma in cholangiocarcinoma is only just beginning to be addressed at the cellular and molecular levels. Nevertheless, there is now increasing evidence to suggest that the desmoplastic reaction, marked by a dramatic accumulation of a-smooth muscle actin positive cancerassociated fibroblasts (a-SMA1CAFs) with increased production of extracellular matrix proteins, proinvasive growth factors and cytokines, antiangiogenic factors, and matrix modifying enzymes may be playing a crucial role in promoting enhanced malignant behavior and therapeutic resistance in cholangiocarcinoma. We also describe recent experimental approaches to prevent cholangiocarcinoma by reducing hepatic fibrosis. Last, we discuss the potential merits and challenges of a-SMA1CAF depletion as a novel strategy for cholangiocarcinoma therapy.
ANCS 2013 general chair's welcome (2013)

It is my great pleasure to welcome you to the Ninth ACM/IEEE Symposium on Architectures for Networking and Communications Systems (ANCS 2013). This year's conference will be held at the Hyatt Place in beautiful downtown San Jose, CA, USA, in the heart of Silicon Valley, on October 21–22, 2013.
Increased Immunoglobulin Production in Vitro in Healthy HLA‐B8‐Positive Persons (1983)

The histocompatibility antigens B8 and DR3 are associated with several autoimmune diseases, and immune hyper-responsiveness has been believed to be one factor in the pathogenesis of these diseases. In the present study we compared the in vitro immunoglobulin production of healthy HLA-B8-positive individuals with that of HLA-B8-negative individuals. In HLA-B8-positive persons a higher number of pokeweed mitogen (PWM)-stimulated Ig-secreting cells was obtained. When the cells were stimulated with PWM in the presence of a physiological concentration of hydrocortisone (HC), the secretion of IgG was significantly higher in HLA-B8-positive individuals. This finding indicates that the PWM-stimulated IgG secretion in healthy HLA-B8-positive individuals is more sensitive for the enhancing action of HC.
Anhidrotic ectodermal dysplasia (EDA) protein expressed in MCF-7 cells associates with cell membrane and induces rounding (1997)

Anhidrotic ectodermal dysplasia (EDA) is a rare X-linked recessive disorder characterized by the absence or hypoplasia of hair, teeth and sweat glands. The gene responsible for the disorder has recently been cloned. The predicted gene product is a 135 amino acid protein with no significant homology to previously known proteins. As a first step to analyze function, we have studied the subcellular localization of the EDA gene product expressed in two epithelial cell lines, COS-1 and MCF-7. Biochemical fractionation and confocal imaging analysis show that, in agreement with a single putative transmembrane domain inferred from its sequence, the EDA protein is transported to the plasma membrane. Moreover, in MCF-7 cells expression of EDA is associated with rounding and detachment of the cells. These results suggest that the EDA protein may be involved in cellular dynamics or signaling.
Simultaneous detection of lung fusions using a multiplex RT-PCR next generation sequencing-based approach: a multi-institutional research study (2018)

This methodology enables simultaneous detection of multiple ALK, ROS1, RET, and NTRK1 gene fusion transcripts in a single panel, enhanced by an integrated analysis solution. The assay performs well on limited amounts of input RNA (10 ng) and offers an integrated single assay solution for detection of actionable fusions in lung adenocarcinoma, with potential savings in both cost and turn-around-time compared to the combination of all four assays by other methods.
Association between SNPs and Loss of Methylation Site on the CpG island of the Promoter Region of the Smoothened Gene, Potential Molecular Markers for Susceptibility to the Development of Basal Cell Carcinoma in the Brazilian Population (2020)

100 samples of paraffined tissue from patients with histopathological diagnosis of BCC and 100 control samples were analyzed for each polymorphism by a newly developed genotyping method, the Dideoxy Single Allele Specific - PCR. The software Bioestat - version 5.3 and Haploview 4.2 were used for the statistical analysis. For all tests a P-value.
Remote substituent effects on regioselectivity in rhodium(I)-catalyzed hydroborations of norbornenes (1992)

Remote substituent effects on the regioselectivity of both the conventional and the rhodium(I)-catalyzed hydroborations of some norbornene derivatives are discussed.
Review of physics underlying recent improvements in silicon solar-cell performance (1980)

A unifying view of the physics of silicon solar cells is presented and used as a basis for explaining how recent improvements in the performance of these cells have been achieved. The unification is facilitated by a region-by-region analysis of the solar cell, which is also used to compare several recently proposed cell structures.
Porphyrin–palladium hydride MOF nanoparticles for tumor-targeting photoacoustic imaging-guided hydrogenothermal cancer therapy (2019)

A nanoscale porphyrin–palladium metal–organic framework (Pd-MOF) with highly dispersive Pd atoms as hydrogen carrier was developed to efficiently load highly reductive hydrogen for the tumor-targeted photoacoustic imaging (PAI)-guided hydrogenothermal therapy of cancer.
Entomopathogenic fungi: unconventional applications (2020)

Abstract Entomopathogenic fungi (EPF) are microorganisms that cause fatal diseases of arthropods. The infection process involves several stages that consist of direct contact of the fungus with the surface of the cuticle of the attacked insect. The factors that determine the effectiveness of the infection process include lytic enzymes, secondary metabolites, and adhesins produced by EPF. Because of their high insecticidal effectiveness, these fungi are commonly used as biopesticides in organic farming. As the environment and farmlands are contaminated with many compounds of anthropogenic origin (e.g., pesticides), the effects of these toxic compounds on EPF and the mechanisms that affect their survival in such a toxic environment have been studied in recent years. This review presents information on the capacity of EPF to remove toxic contaminants, including alkylphenols, organotin compounds, synthetic estrogens, pesticides and hydrocarbons. Moreover, these fungi produce numerous secondary metabolites that can be potentially used in medicine or as antimicrobial agents. Despite their huge potential in biocontrol processes, the use of EPF has been underestimated due to a lack of knowledge on their abilities. In our work, we have presented the available data on the possibilities of the additional and unconventional use of these microorganisms.
Using Computer Intelligence for Depression Diagnosis and Crowdsourcing (2016)

This installment of Computer's series highlighting the work published in IEEE Computer Society journals comes from IEEE Transactions on Affective Computing and IEEE Transactions on Knowledge and Data Engineering.
Strategic Importance of RFID - The CIO Perspective An Empirical Analysis in Germany (2006)

RFID is currently considered a hot topic in the IT arena.It is described as major enabling technology for automated contactless wireless data collection, and as an enabler for the real-time enterprise, a future vision of enterprise information systems.But little is known about the perceived strategic importance of RFID among IT decision makers, current RFID usage and areas of application, or companies' intentions to invest in RFID.In this paper we intend to fill this gap.We convey a quantitative survey among CIOs in Germany across various industries.We present empirical insights on CIOs' perceptions of RFID regarding its strategic importance, the relevance of RFID compared to other IT topics, and their RFID visions for the future of their company.
Über substituierte 2.3‐Benzyliden‐ribonucleoside (1964)

Abstract Die Darstellung von [4‐Dimethylamino‐benzyliden]‐ und [2.4‐Dimethoxy‐benzyliden]‐ribonucleosiden wird beschrieben. Diese Verbindungen werden rasch unter milden sauren Bedingungen hydrolysiert und lassen sich mit 2‐Cyanäthylphosphat/Dicyclohexylcarbodiimid phosphorylieren. Nach Abspalten der Schutzgruppen erhält man ausschließlich Nucleosid‐5′‐phosphate.
Geochemical Prospecting--A Critical Review: ABSTRACT (1964)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Plasma membrane and intracellular expression of globotetraosylceramide (globoside) in mouse bone marrow-derived mast cells. (1986)

The cellular localization of globotetraosylceramide (globoside), one of the predominant neutral glycosphingolipids of mouse interleukin 3-dependent, bone marrow culture-derived mast cells (BMMC), has been determined by immunologic and chemical methods. Although less than 10% of BMMC expressed globoside on their surface, as assessed by cytofluorographic analysis of the binding of a mouse monoclonal IgM anti-globoside antibody, treatment of BMMC with nonactivating doses of pronase, trypsin, or neuraminidase increased the percentage of BMMC binding anti-globoside antibody by an average of six, three, or sixfold respectively. That most BMMC had globoside on their plasma membrane was confirmed by the surface radiolabeling of globoside with galactose oxidase and sodium borotritide, as detected by autoradiography of thin layer chromatograms of the extracted neutral glycosphingolipids. Thus, BMMC expressed globoside on their plasma membrane, but accessibility of a large probe such as IgM antibody to the glycosphingolipid was impeded by surrounding surface molecules. All BMMC bound anti-globoside antibody intracellularly, as assessed by indirect immunofluorescence staining and fluorescence microscopy on acetone-permeabilized cells, and the pattern of staining suggested that globoside was associated with the secretory granules of BMMC. Immunologic activation of BMMC resulted in a fivefold increase in the surface expression of globoside, as detected by cytofluorographic analysis of the binding of monoclonal anti-globoside antibody. The findings suggest that activation of BMMC causes a reorganization of the plasma membrane such that globoside is more exposed or that activation is accompanied by movement of globoside from internal membranes to the plasma membrane. The increased expression of globoside is a novel marker of the activated mouse BMMC.
Impact of patient adherence on the cost-effectiveness of noninvasive tests for the initial diagnosis of Helicobacter pylori infection in the United States (2016)

Based on a comprehensive modeled analysis that included consideration of patient test adherence and long-term consequences resulting from continuing H. pylori infection, the UBT provided the greatest economic value among noninvasive tests for diagnosis of H. pylori infection, because of high patient adherence and excellent test performance.
Two Metal–Organic Frameworks Constructed from One-Dimensional Cobalt(II) Ferrimagnetic Chains with Alternating Antiferromagnetic/Ferromagnetic and AF/AF/FM Interaction: Synthesis, Structures, and Magnetic Properties (2012)

Here, we report two three-dimensional metal-organic frameworks of formula [Co(2)(4-ptz)(2)(bpp)(N(3))(2)](n) (1) and [Co(3)(OH)(2)(bdt)(2)(bpp)(2)(H(2)O)(2)](n) (2), which were synthesized by hydrothermal reaction from the respective tetrazole ligand (5-(4-pyridyl)tetrazole (4-H-ptz) for 1 and 5,5'-(1,4-phenylene)bis(1-H-tetrazole) (H(2)bdt) for 2), long and flexible pyridyl-containing ligand 1,3-bi(4-pyridyl)propane (bpp), NaN(3), and CoCl(2). Both 1 and 2 consist of well-isolated one-dimensional cobalt(II) alternating chains further linked by the bpp and/or the tetrazole ligand, while their chain structures are totally different. The chains of 1 are formed by Co(2+) ions bridged by single μ-EE-N(3) and triple (μ-EO-N(3))(μ-tetrazole)(2) alternately, whereas the Co(2+) ions are bridged by μ(3)-OH to form Co(3)(OH)(2) chains in compound 2. Magnetic measurements demonstrate that compound 1 contains an alternating antiferromagnetic (AF)/ferromagnetic (FM) ferrimagnetic chain, while compound 2 exhibits the coexistence of spin canting, slow magnetic dynamics, and finite-size effect, with alternating AF/AF/FM ferrimagnetic chains.
Graphene and Graphene Oxide Can “Lubricate” Ionic Liquids based on Specific Surface Interactions Leading to Improved Low‐Temperature Hypergolic Performance (2012)

Weltraumtaugliche Schmiermittel: Graphen und Graphenoxid (r-GO) können das Tieftemperaturverhalten hypergolischer ionischer Flüssigkeiten drastisch verbessern, indem sie deren Viskosität reduzieren. Entscheidend dabei ist, dass die Art des Graphens auf die spezifische Funktionalität der IL abgestimmt wird. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.