gebhart/patrepeval huggingface dataset:
Is Home Biofeedback Training Useful for Fecal Incontinence: Preliminary Fesults of RCT With New Home Device (2017)

Introduction: Biofeedback therapy (BT) is useful in fecal incontinence (FI), but it is labor intensive, not widely available and reimbursement is problematic. We tested the efficacy of home device assisted BT against standard office BT. Methods: Patients with FI (at least 1 episode / week) were randomized to office BT or home BT using a novel biofeedback device (InToneMV, InControl Medical, WI, USA). Home device consists of a probe with balloon, a pump for balloon inflation, a hand held monitor with voice guided therapy, and both mechanical and electrical stimulation of anal sphincters. Home BT patients were asked to use home device twice daily for 20 minute session. Office BT patients practiced Kegel exercise twice daily at home and had 6, one hour, weekly office BT consisting of anal strengthening, endurance training and coordination training for 6 weeks. All participants kept daily stool diaries. Bowel symptoms, fecal incontinence severity index (FISI), fecal incontinence and constipation assessment (FICA), subject's global assessment (SGA) and physiological changes (anorectal manometry) were assessed at baseline and post-treatment period. Responder was defined as ≥50% decrease in weekly FI episodes compared to baseline. Results: Eighteen (16 females, 63.6±13.4 years old) FI patients were enrolled: 11 (home BT) and 7 (office BT). There were 6/11 (55%) responders in Home BT and 3/7(43%) in Office BT (p=1.000). In Home BT, FI symptom severity (visual analog scale, VAS) improved in 10 (91%) and unchanged in 1 (9%), compared to 3 (43%) improved in Office BT and was unchanged in 1 (17%) and worse in 3 (43%). Similarly, 9% reported completely relief and 64% reported considerable relief with Home BT compared to 29% reported considerable relief with Office BT (Table 1). The mean FISI score increased and FICA score decreased in Home BT when compared to baseline (3.6 and 3.3, p=0.016 and p=0.033) and in Office BT (1.0 and 1.2 p=0.435 and p=0.330). The mean anal resting, maximal squeeze and sustained squeeze pressure increases were comparable (6.8, 25.3 and 5.21 mmHg in Home BT and 21.3, 37.6 and 14.4mmHg in Office BT respectively).Table: Table. Patients' self-assessment of the treatment effectConclusion: Home BT using a voice guided program of mechanical and electrical stimulation is a promising approach for treatment of FI, and provides comparable physiologic and somewhat better symptomatic benefit when compared to office BT. The convenience of home BT may prove beneficial in long term and reduce health care burden.
Covid-19 Detection Based on Chest X-Ray Images Using DCT Compression and NN (2022)

Covid-19 is a highly contagious virus spreading all over the world. It is caused by SARS-CoV-2. virus. Some of the most common symptoms are fever, cough, sore throat, tiredness, and loss of smell or taste. There are two types of tests for COVID-19: the PCR test and the antigen test. Automatic detection of Covid-19 from publicly available resources is essential. This paper employs the commonly available chest x-ray (CXR) images in the classification of Covid-19, normal and viral pneumonia cases. The proposed method divides the CXR images into subblocks and computes the Discrete Cosine Transform (DCT) for every subblock. The DCT energy compaction capability is employed to produce a compressed version for each CXR image. Few spectral DCT components are incorporated as features for each image. The compressed images are scanned by average pooling windows to reduce the dimension of the final feature vectors. A multilayer artificial neural network is employed in the 3-set classification. The proposed method achieved an average accuracy of 95 %. While the proposed method achieves comparable accuracy relative to recent state-of-the-art techniques, its computational burden and implementation time is much less.
New Cytotoxic Alkaloids from the Wood of Vepris punctata from the Madagascar Rainforest (2003)

Bioassay-guided fractionation of a CH(2)Cl(2)/MeOH extract of the wood of Vepris punctata resulted in the isolation of three new furoquinoline alkaloids, 5-methoxymaculine (1), 5,8-dimethoxymaculine (2), and 4,5,6,7,8-pentamethoxyfuroquinoline (3), in addition to the four known alkaloids flindersiamine (4), kokusaginine (5), maculine (6), and skimmianine (7). The structures of the new alkaloids 1-3 were established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. All the isolated compounds were tested against the A2780 human ovarian cancer cell line, and all seven alkaloids showed weak cytotoxic activity.
Effects of phenolic acid metabolites formed after chlorogenic acid consumption on retinal degeneration in vivo (2015)

CGA and coffee metabolites, especially, CA, and DHCA, reach the eye, where they can significantly reduce apoptosis induced by hypoxia and optic nerve crush stress, and thus prevent retinal degeneration.
Photo‐biocatalytic One‐Pot Cascades for the Enantioselective Synthesis of 1,3‐Mercaptoalkanol Volatile Sulfur Compounds (2018)

The synthesis of enantiomerically pure 1,3-mercaptoalkanol volatile sulfur compounds through a one-pot photo-biocatalytic cascade reaction is described. Two new KRED biocatalysts with opposite enantioselectivity were discovered and proved to be efficient on a wide range of substrates. The one-pot cascade reaction combining photocatalytic thio-Michael addition with biocatalytic ketoreduction in an aqueous medium provides a green and sustainable approach to enantiomerically pure 1,3-mercaptoalkanols in high yields with excellent enantioselectivity.
Safe start-up procedures of isolated bi-directional DC-DC converter (2010)

This paper presents a safe start-up procedures of an isolated bi-directional DC-DC converter in buck and boost modes. This converter has been developed as a part of multifunctional up to 4 kW power supply system that uses a high voltage (450 V) DC-link. The isolated bi-directional DC-DC converter can charge 28 V batteries and supply auxiliary low voltage DC loads. Additionally, the isolated bidirectional converter can also draw power from the batteries or from truck's engine driven alternator to keep maintain the high voltage DC-link. Modulation strategies, start-up procedures and control of this converter have been validated by using the Matlab SymPowerSystems Toolboxes and finally, they have been also experimentally verified.
Estimaciones demográficas en países con estadísticas incompletas: la Encuesta Demográfica Nacional de Honduras (EDNH) (1973)

As in most underdeveloped countries, the demographic statistics obtained from the civil registration in Honduras are not sufficiently complete for making the necessary population estimates for economic and social planning.To remedy this deficiency to a certain extent, the "National Demographic Survey of Honduras" known as EDENH, (Encuesta Demogrfica Nacional de Honduras) was carried out, using a system of repeated visits.This survey started in December 1970 and ended in October 1972.During this period four rounds of interviews were carried out.The initial size of the sample was approximately 35,000 persons, but in the subsequent rounds additional people were included in the survey, because of being born into or becoming a new resident of the research area, so that at the end of the fourth round, more than 50,000 persons had been included in the study.Sorne results of the survey are indicated in tables l to 5, which refer to the two principal demographic variables, fertility and mortality.
Self testing for diabetes mellitus. (1991)

A postal request system for self testing for postprandial glycosuria in people aged 45-70 is a simple and effective method of population screening for diabetes mellitus.
ChemInform Abstract: Palladium‐Catalyzed Coupling Reactions of Thioimidate N‐Oxides: Access to α‐Alkenyl‐ and α‐Aryl‐Functionalized Cyclic Nitrones. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
GROwrn AND ELECTRONIC TRANSPORT IN TIDN EPITAXIAL CoSi2 - Si HETEROSTRUCTURES (1989)

Thin epitaxial Cosi2 layers on si have been grown by direct reaction in ultrahigh vacuum. The reaction path from si + Co to Cosi2 as a fonction of the initial Co thickness will be described, along with the evolution of interface roughness as seen by high resolution TEM. The generation of pinholes during high temperature annealing will be discussed as a function of geometry and stress relaxation. Electrical measurements (resistivity, Hall effect and super conducting transition temperature) will be presented on thin layers made either by direct reaction or by codeposition, with particular emphasis on the effect of interfaces on electronic transport.
L-histidinol increases the vulnerability of cultured human leukemia and lymphoma cells to anticancer drugs. (1994)

L-Histidinol, a structural analogue of the essential amino acid L-histidine, enhances the toxicity of a variety of anticancer drugs for many tumor cells of animal origin. In this study, the effects of L-histidinol on the proliferation and anticancer drug susceptibility of two human tumor cell lines of lymphoid origin, Daudi and MOLT 4, have been examined. L-Histidinol increased the inherent capacity of six different antineoplastic agents to kill these human tumor cells, in a dose- and time-dependent manner, in spite of the observation that it slowed cell cycle progression in both lines.
CSD 1882200: Experimental Crystal Structure Determination (2019)

An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the joint CCDC and FIZ Karlsruhe Access Structures service and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Effects of sheath potential of source plasma on characteristics of low energy beam extraction (1994)

In order to obtain a high brightness ion beam from a plasma ion source in the low energy region (150 eV), the effects of sheath potential on the ion beam characteristics such as beam divergence and brightness have been studied experimentally. A bucket-type ion source (magnetic multicusp ion source) with an accel–decel triode extraction system is used for the experiment. Bias voltage between a discharge chamber and a positive (plasma) electrode is applied for sheath potential control. Two types of electrode systems have been examined, such as straight hole aperture (S type) and recessed hole aperture (R type), and have found that the effects of the bias voltage on the beam characteristics depend on the type of aperture and the deceleration voltage. For an S-type system, the application of bias voltage improves the beam performance in a low deceleration voltage (−600 V), but not in a high deceleration voltage (−1600 V). For an R-type system, almost no improvement is observed in all deceleration voltages. Although the highest brightness is obtained in a deceleration voltage of −1600 V without the application of bias voltage in the S-type system, the significant fraction of the intersecting beam to the electrodes is present in this case.
Analysis of Open Source Boost (C++ libraries) for Design of Game Network (2015)

Open source Boost Lib in this paper is to propose a distributed processing architecture of the game server, and the server models the whole vertical extension of the load generated by a specific process, the load on the game server for both the horizontal scale model of a typical distributed system, Dispersing the processing game process, and corresponds to the load.Multi-server architecture is distributed into the game world to the local level. Since the distributed server to process by integrating the entire process of the game server divided area, when only a specific process, the throughput increases a load to cause the load itself is transferred, the entire game server the local server is slow. If the load is generated in the specific process in the multi-server architecture must scale the game server or the game server cluster. However, while the load of a particular server extensions are uneconomic to process less meaningless. Therefore, the conventional method of dispersing uniformly without separate operations for all the processes are dispersed to the more process unit will be more and better ways to game services in general reliable service throughout is possible. for all the processes are dispersed to the more process unit will be more and better ways to game services in general reliable service throughout is possible.
U. S. /CIS eye joint nuclear rocket venture (1993)

An account is given of the significance for U.S. spacecraft development of a nuclear thermal rocket (NTR) reactor concept that has been developed in the (formerly Soviet) Commonwealth of Independent States (CIS). The CIS NTR reactor employs a hydrogen-cooled zirconium hydride moderator and ternary carbide fuels; the comparatively cool operating temperatures associated with this design promise overall robustness.
A New Synthesis of Chlorins. (2001)

Abstract For Abstract see ChemInform Abstract in Full Text.
Antitumor effect of forbesione isolated from Garcinia hanburyi on cholangiocarcinoma in vitro and in vivo (2016)

Cholangiocarcinoma (CCA) is a malignancy with no effective therapy and poor prognosis. Forbesione, a caged xanthone isolated from <i>Garcinia hanburyi</i>, has been reported to inhibit proliferation and to induce apoptosis in human CCA cell lines. The present study aimed to further explore the potential anticancer properties of forbesione by testing its effects against the hamster CCA cell line Ham-1 <i>in vitro</i> and <i>in vivo</i>. It was observed that forbesione inhibited the growth of Ham-1 cells <i>in vitro</i> and suppressed Ham-1 growth as allograft in hamsters by inducing cell cycle arrest at the S phase. This was mediated by decreasing the protein expression of cyclin E, cyclin A and cyclin-dependent kinase 2. In addition, increased expression of p21 and p27 was detected, which could possibly explain the reduced expression of proliferating cell nuclear antigen and of the bile duct cell marker cytokeratin 19 observed in forbesione-treated Ham-1 cells <i>in vitro</i> and in tumor tissues of forbesione-treated hamsters. Furthermore, forbesione induced apoptosis through multiple pathways. The death receptor pathway was activated by increased expression of Fas, Fas-associated death domain and activated caspase-3, along with decreased expression of procaspase-8 and procaspase-3. The mitochondrial pathway was driven by increased expression of B-cell lymphoma (Bcl)-2-like protein 4, activated caspase-9 and inhibitor of κB-α, along with decreased expression of Bcl-2, survivin, procaspase-9 and nuclear factor-κB/p65. The endoplasmic reticulum pathway was stimulated by increased expression of activated caspase-12 and decreased expression of procaspase-12. No side effects or toxicity were observed in forbesione-treated hamsters. Thus, forbesione is a potential drug candidate for cancer therapy that deserves further investigation.
A 2000-Atmosphere Bulk-Type Pressure Sensor Realized on (001) Substrate with Selective Stress-Filtering Trenches (2019)

Previously reported was a bulk-type pressure sensor without fragile movable microstructure and constructed on [110]-oriented silicon substrate. Hydrostatic pressure acting on the sensor was converted to biaxial compression inside an encapsulated vacuum cavity. Two pairs of piezoresistors were used to form a Wheatstone bridge, with one pair each aligned with the [001] and [110] orientations – thus optimally utilizing the anisotropy of silicon piezoresistance on the (110) substrate. However, such anisotropy is absent on the (001) substrate because of an inherent crystal-symmetry. Presently reported is the placement of stress-filtering trenches adjacent to a selected pair of the constituent piezoresistors forming the Wheatstone bridge, thus removing the stress-symmetry by converting the local stress field from biaxial to uniaxial and allowing the construction of the bulk-type sensor on the more commonly available (001) substrate. A junction-isolated version of the pressure sensor was realized and characterized to 200 MPa (∼2000 atmospheres) and 175 °C, with better potential for sensor-CMOS integration.
Sensible Heat Loss after Systemic Anticholinergic Treatment (1994)

SummarySystemic atropine administration decreases eccrine sweat gland release via competitive inhibition at cholinergic receptors and augments skin blood flow by a yet unknown mechanism. Increased skin blood flow promotes auxiliary radiative and convective heat flux by 20–100% in both warm and cold environments. These studies showed that the systemic dose of atropine (2 mg, im) was sufficient to block cholinergic sweat gland activity and core and skin temperatures were higher after atropine compared to control experiments. There was an enhanced skin blood flow thermosensitivity to esophageal temperature drive following atropine administration.
Product environmental impact assessments (2002)

Process engineers have for years evaluated the potential impact of their operations to the environment. They do this not only because it is the right thing to do, but also because governments around the world have continued to pass regulations requiring it. Thus, companies have become accustomed to environmental protection as a normal part of manufacturing operations. As our knowledge has increased, we have learned that to truly protect the environment, we must carry this protection beyond the manufacturing process and into the intended product's entire life cycle. Companies must include a careful analysis of a product's total impact to the environment from "cradle to grave". The authors describe the Environmental Impact Assessment tool, developed at IBM Austin, which is used to describe all new products. It is utilised to describe various details and aspects associated with the new product.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Bioaugmentation with Nitrifying Bacteria Acclimated to Different Temperatures (2005)

A nitrifying biomass was produced from anaerobic sludge dewatering liquors for the purpose of bioaugmentation of sequencing batch reactors (SBRs). Nitrification of centrate was conducted at four temperatures (10, 20, 25, and 30°C) while the seeded SBRs were operated at 10°C with a solids retention time of approximately 4 days. The SBRs did not exhibit any nitrification before the onset of seeding. When the hydraulic retention time (HRT) was 24 h, partial removal of NH3–N occurred when seed acclimated to 20, 25, and 30°C was added. When the HRT was 12 h, only the SBR seeded with nitrifying biomass acclimated to 10°C achieved 50% NH3–N removal. Complete removal of NH3–N was not achieved in any of the seeded SBRs. The degree of NH3–N removal in the seeded SBRs was dependent on the initial temperature of the seed, and the observed growth rates of the nitrifying bacteria were inversely proportional to the change in temperature.
Generation of mice that conditionally express the activation domain of Notch2 (2009)

The Notch pathway is an intercellular signaling mechanism frequently used for controlling cell fate during organogenesis. There are four structurally related Notch receptors in mice and humans, and Notch1 and Notch2 are essential genes. In this report we describe the construction of a transgenic mouse strain that expresses the Notch2 intracellular domain in response to cell lineage specific expression of Cre recombinase. This approach bypasses the requirement for ligand- receptor interaction and allows the direct determination of the consequences of Notch2 activation in vivo. Exogenous expression of the Notch2 intracellular domain resulted in the developmental arrest of secondary heart field derived cardiomyocytes during the transition from immature alpha-Smooth Muscle Actin expressing cells to mature alpha-Actinin positive cardiomyocytes. In contrast, a cell nonautonomous mesenchymal expansion was observed in semilunar valves. This new conditionally expressed allele of Notch2 can be used in studies by investigators interested in the effects of Notch2 activation in vivo.
ChemInform Abstract: HIV Inhibitory Natural Products. Part 7. The Calanolides, a Novel HIV‐ Inhibitory Class of Coumarin Derivatives from the Tropical Rainforest Tree, Calophyllum lanigerum. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Experimental and Computational Evidence for 1,4-Diradical Intermediates in Reactions of Cobalt Fluorocarbene Complexes with Terminal Aryl-alkynes to give Metallacyclobutenes (2017)

Cobalt fluorocarbene complex CpCo(═CF(CF3))(PPh2Me) (Cp = η5-cyclopentadienyl) reacts with para-substituted phenylacetylenes to furnish partially fluorinated cobaltacyclobutene complexes [Cp(PPh2Me)Co{κ2-C(Ar)═CHCF(CF3)}], which were isolated and characterized by elemental analysis, multinuclear NMR and UV–vis spectroscopy, and X-ray crystallography. The scope of reactivity between CpCo(═CFRF)(L) and various alkynes was explored. The detailed pathway for the [2 + 2] cycloaddition reaction was investigated using a combination of kinetic studies and DFT computational chemistry (M06/def2-TZVP), with a 1,4 diradical species identified as the key intermediate.
Similarity of Migration Inhibitory Factor(s) Produced by Human Lymphoid Cell Line and Phytohemagglutinin and Tuberculin-Stimulated Human Peripheral Lymphocytes (1974)

Abstract The migration inhibitory factor(s) (MIF) derived from the supernatants of an established human lymphoid cell line (PGLC-33H) and from human peripheral lymphocytes stimulated in vitro by phytohemagglutinin (PHA) and tuberculin (PPD) were characterized and compared. Separation of these supernatants by differential ultrafiltration showed peak inhibitory activity for all three in the fraction containing molecules of the size 10,000 to 50,000. Separation by Sephadex gel filtration (G-75) revealed similar elution profiles for these MIF. Peak inhibitory activity eluted between enzyme markers of m.w. 17,000 and 25,000. The MIF activity contained in these supernatants was found to be heat stable (56°C for 30 min) and chymotrypsin sensitive. The MIF derived from human long term lymphoid cell lines appears to be similar to the MIF produced by human peripheral lymphocytes stimulated in vitro by mitogen and antigen.
Microscopic flow measurements with optically trapped microprobes (2002)

The use of optical tweezers to measure micrometer-resolution velocity fields in fluid flow is demonstrated as an extension of a scanning confocal viscosity microscope. This demonstration is achieved by detection of the motion of an optically trapped microsphere in an oscillating laser trap. The technique is validated by comparison with an independent video-based measurement and applied to obtain a two-dimensional map of the flow past a microscopic wedge. Since the velocity is measured simultaneously with the trap relaxation time, the technique requires no fluid-dependent calibration and is independent of the trap stiffness and the particle size.