gebhart/patrepeval huggingface dataset:
Novel Peptidomimetics for Inhibition of HER2:HER3 Heterodimerization in HER2‐Positive Breast Cancer (2014)

The current approach to treating HER2-overexpressed breast cancer is the use of monoclonal antibodies or a combination of antibodies with traditional chemotherapeutic agents or kinase inhibitors. Our approach is to target clinically validated HER2 domain IV with peptidomimetics and inhibit the protein-protein interactions (PPI) of HERs. Unlike antibodies, peptidomimetics have advantages in terms of stability, modification, and molecular size. We have designed peptidomimetics (compounds 5 and 9) that bind to HER2 domain IV, inhibit protein-protein interactions, and decrease cell viability in breast cancer cells with HER2 overexpression. We have shown, using enzyme fragment complementation and proximity ligation assays, that peptidomimetics inhibit the PPI of HER2:HER3. Compounds 5 and 9 suppressed the tumor growth in a xenograft mouse model. Furthermore, we have shown that these compounds inhibit PPI of HER2:HER3 and phosphorylation of HER2 as compared to control in tissue samples derived from in vivo studies. The stability of the compounds was also investigated in mouse serum, and the compounds exhibited stability with a half-life of up to 3 h. These results suggest that the novel peptidomimetics we have developed target the extracellular domain of HER2 protein and inhibit HER2:HER3 interaction, providing a novel method to treat HER2-positive cancer.
Inhibition of YAP/TAZ Activity in Spinal Cord Suppresses Neuropathic Pain (2016)

Mechanisms that underlie neuropathic pain remain elusive. We have demonstrated recently that nerve injury can activate Wnt signaling, which becomes a trigger for the development of neuropathic pain. We report that the transcriptional regulators YAP and TAZ, which orchestrate Wnt response via incorporation in the β-catenin destruction complex, are key in the pathogenesis of neuropathic pain and may serve as an "ON-OFF" switch for neuropathic pain status. Further, we discovered a new small molecule, dCTB, which targets YAP/TAZ/β-catenin and can greatly suppress neuropathic pain. Our study reveals that YAP and TAZ are core mechanisms underlying the pathogenesis of neuropathic pain and are targets in the screening of potent analgesics for the treatment of neuropathic pain.
Raman Spectroscopic Evidence for Cooperative C−H···O Interactions in the Acetaldehyde−CO2 Complex (2002)

In carbonyl compounds having a hydrogen atom attached to the alpha-carbon or directly to the carbonyl carbon, our recent ab initio and solvation studies have predicted the presence of a weak C-H...O interaction with CO2. This intermolecular interaction acts cooperatively with the Lewis acid-Lewis base interaction that exists between CO2 and the carbonyl group. This communication provides the first experimental evidence for this cooperative interaction in the acetaldehyde-CO2 complex using Raman spectroscopy at 25.0 degrees C in the gas phase. The implications of these interactions in the solvation of carbonyl-based CO2-philes are also discussed.
The BTSC Multichannel Television Sound System (1986)

The quest for a method of broadcasting stereophonic sound and second language with television goes back many decades. There was a flurry of activity, worldwide, in the late 1950's and early 1960's. In the mid 1960's, the question was raised again in the U.S., but was dropped because of the lack of interest. In the 1970's, both Japan and West Germany adopted standards.
Multi-stage fusion for face localization (2005)

We present a new method dedicated to the localization of faces in color images. It combines a connexionist model (auto-associative network), an ellipse model based on generalized Hough transform, a skin color model and an eyes detector that results in two features. A linear combination of the 3 first models is performed to eliminate most of non face regions. A connexionist combination of the four detectors response is performed on the remaining candidates. Given an input image, we compute a kind of probability map on it with a sliding window. The face position is then determined as the location of the absolute maximum over this map. Improvement of baseline detectors localization rates is clearly shown and results are very encouraging.
Analysis of tRNA halves (tsRNAs) in serum from cattle challenged with bovine viral diarrhea virus (2019)

Acute infections of bovine viral diarrhea virus (BVDV) lead to a range of clinical presentations. Laboratory tests for detection depend on collection of samples during a short viremia. Acutely infected animals remain largely undiagnosed. Transfer RNA halves (tsRNAs) are hypothesized to function like microRNAs to regulate gene expression during an immune response. The objective of this study was to identify tsRNAs in cattle that had been challenged with a non-cytopathic field strain of BVDV. Colostrum-deprived neonatal Holstein calves were either challenged with BVDV (n=5) or mock challenged (n=4). Sera was collected prior to challenge and days 4, 9, and 16 post challenge. RNA was extracted and read counts of small non-coding RNAs were assessed using next-generation sequencing. A total of 87,838,207 reads identified 41 different tsRNAs. Two 5' tsRNAs, tsRNAProAGG and tsRNAValAAC, differed across time. Two 5' tsRNAs, tsRNAGlyCCC and tsRNAGlyGCC, differed between treatment groups across time. Four days post challenge, 5' tsRNAGlyCCC and tsRNAGlyGCC were significantly lower in the challenged group than the control group. Further studies are needed to identify the importance and function of 5' tsRNAGlyCCC and tsRNAGlyGCC in serum samples of cattle challenged with BVDV.
Bacterial Proliferation May Be the Key Component of Sepsis Mortality (2018)

Halbach et al. ([1][1]) reported that antibiotic administration had no significant effect on mortality in a mouse model of intra-abdominal infection (IAI) using cecal ligation and puncture. Furthermore, ligation of the cecum without puncture followed by the introduction of sterile feces into the
Indane-1,3-Dione: From Synthetic Strategies to Applications (2022)

Indane-1,3-dione is a versatile building block used in numerous applications ranging from biosensing, bioactivity, bioimaging to electronics or photopolymerization. In this review, an overview of the different chemical reactions enabling access to this scaffold but also to the most common derivatives of indane-1,3-dione are presented. Parallel to this, the different applications in which indane-1,3-dione-based structures have been used are also presented, evidencing the versatility of this structure.
MOTOR CORTEX STIMULATION FOR THE ENHANCEMENT OF RECOVERY FROM STROKE (2008)

OBJECTIVE: Functional magnetic resonance imaging and transcranial magnetic stimulation studies suggest that human cortex shows evidence of neuroplasticity. Preclinical studies in rats and monkeys suggest that motor cortical stimulation can enhance plasticity and improve recovery after stroke. This study assesses the safety and preliminary efficacy of targeted subthreshold epidural cortical stimulation delivered concurrently with intensive rehabilitation therapy while using an investigational device in patients with chronic hemiparetic stroke. METHODS: This is a prospective, multicenter, and nonblinded trial randomizing patients to rehabilitation with or without cortical stimulation. Patients aged 20 to 75 years who had had an ischemic stroke at least 4 months previously causing persistent moderate weakness of the arm were included. Functional magnetic resonance imaging localized hand motor function before surgery to place an epidural cortical electrode. Both groups then underwent rehabilitation for 3 weeks after which the electrode was removed. Outcome measures were obtained at baseline, during therapy, and at 1, 4, 8, and 12 weeks postprocedure. RESULTS: Ten patients were randomized; six patients to surgery, four to the control group. No patient deaths, neurological deterioration, or seizures occurred. There were two infections from nonprotocol-related causes. Of the eight patients completing the treatment, the stimulation plus rehabilitation group improved significantly better than controls in the Upper Extremity Fugl-Meyer (P = 0.003 overall) and the hand function score of the Stroke Impact Scale (P =0.001 overall). CONCLUSION: The technique of cortical stimulation to enhance stroke recovery is well tolerated and safe.
Assessment of upper tropospheric HOx sources over the tropical Pacific based on NASA GTE/PEM data: Net effect on HOx and other photochemical parameters (1999)

Data for the tropical upper troposphere (8–12 km, 20°N‐20°S) collected during NASA's Pacific Exploratory Missions have been used to carry out a detailed examination of the photochemical processes controlling HO x (OH+HO 2 ). Of particular significance is the availability of measurements of nonmethane hydrocarbons, oxygenated hydrocarbons (i.e., acetone, methanol, and ethanol) and peroxides (i.e., H 2 O 2 and CH 3 OOH). These observations have provided constraints on model calculations permitting an assessment of the potential impact of these species on the levels of HO x , CH 3 O 2 , CH 2 O, as well as ozone budget parameters. Sensitivity calculations using a time‐dependent photochemical box model show that when constrained by measured values of the above oxygenated species, model estimated HO x levels are elevated relative to unconstrained calculations. The impact of constraining these species was found to increase with altitude, reflecting the systematic roll‐off in water vapor mixing ratios with altitude. At 11–12 km, overall increases in HO x approached a factor of 2 with somewhat larger increases being found for gross and net photochemical production of ozone. While significant, the impact on HO x due to peroxides appears to be less than previously estimated. In particular, observations of elevated H 2 O 2 levels may be more influenced by local photochemistry than by convective transport. Issues related to the uncertainty in high‐altitude water vapor levels and the possibility of other contributing sources of HO x are discussed. Finally, it is noted that the uncertainties in gas kinetic rate coefficients at the low temperatures of the upper troposphere and as well as OH sensor calibrations should be areas of continued investigation.
Epigenome-wide association study of short-term temperature fluctuations based on within-sibship analyses in Australian females (2022)

Short-term temperature fluctuations were associated with differentially methylated signals across the human genome, which provides evidence on the potential biological mechanisms underlying the health impact of temperature fluctuations. Future studies are needed to further clarify the roles of DNA methylation in diseases associated with temperature fluctuations.
Synthesis of New Hybrid Mineral / Renewable Sol-Gel Matrices by Inter-Cross-Linking Siloxane Based Polymers with Polysaccharides (2010)

International audience
Avoiding hypernatraemic dehydration in healthy term infants (2007)

Perspective on the paper by van Dommelen et al (see page 490)
Nigroxanthin (3?,4?-Didehydro- ?,?-carotene-3,6?-diol), a New Carotenoid Isolated from Paprika (Capsicum annuum var. longum nigrum) (1994)

From red paprika (Capsicum annuum var. longum nigrum) nigroxanthin (1) was isolated as a minor carotenoid and, based on its spectral data, identified as (all-E)-3?,4?-didehydro-?,?-carotene-3,6?-diol.
A Study on Control of a Power-assisted Chair Based on Motion-sensing Concept (2006)

Generally, a power-assisting device should provide appropriate support for various physical conditions of persons who need supports. Therefore motion-sensing concept is introduced into the control system for the power-assisted chair, which is driven by a pneumatic cylinder. The concept is based on real-time modification of a desired path. The path is transformed with respect to time axis according to difference between a standard force pattern and an actual force pattern acting on a floor. This method is expected to realize more adaptive assisting. The control system was implemented to the power-assisted chair. The effect was investigated by experiment on the system
Radial Shearing Interferometer (1963)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Eric Donath and Warren Carlough, "Radial Shearing Interferometer," J. Opt. Soc. Am. 53, 395-395 (1963) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Physical Data Auditing for Attack Detection in Cyber-Manufacturing Systems: Blockchain for Machine Learning Process (2019)

Abstract Auditing physical data using machine learning can enhance the security in Cyber-Manufacturing System (CMS). However, the physical data processing itself is prone to cyber-attacks. Connections based on the internet in CMS opens the route for adversaries to compromise the attack detection system itself. To prevent data from malicious data injection in CMS, this paper proposes an enhanced Simple Convolutional Neural Network (SCNN) based attack detection system employing a blockchain. There are three contributions of this paper: (i) introducing a secure attack detection system using blockchain, (ii) optimizing the cost and time for CMS by training on the simulated images, and (iii) presenting a real-time attack detection system for CMS by simplifying the convolutional neural network. The paper demonstrates the effectiveness of the blockchain implementation by presenting the comparative performance analysis of the proposed attack detection system with and without blockchain implementation using an example of a simulated attack on the machine learning process.
A voltage divider with autocalibration - a version with single compensation (2016)

Wydawnictwo SIGMA-NOT wydaje czasopisma fachowe informujące swoich czytelników o najnowszych osiągnięciach naukowych i nowoczesnych rozwiązaniach technicznych w Polsce i na świecie, popularyzuje problemy techniczne oraz poszerza wiedzę i kulturę techniczną.
Epidemiology of the metabolic syndrome in the USA (2010)

The metabolic syndrome is a common complex entity that has emerged as a worldwide epidemic and major public health care concern with a prevalence of approximately 25% in the United States. There have been a number of different definitions of the metabolic syndrome but all center around the metabolic abnormalities of central obesity, hypertension, decreased high-density lipoproteins and elevated triglycerides with insulin resistance as the uniting physiologic factor. The importance of the metabolic syndrome is not just related to its high prevalence rate but also because it predicts the development of diabetes and cardiovascular disease. Nonalcoholic fatty liver disease is now recognized to be the hepatic component of the metabolic syndrome, which along with its individual components - particularly diabetes and elevated triglycerides, are the major risk factors for the development of nonalcoholic steatohepatitis (NASH); the most severe form of nonalcoholic fatty liver disease. NASH may progress to cirrhosis, hepatocellular carcinoma, and liver failure. It is currently the third most common cause for liver transplantation and is projected to be the leading cause for liver transplantation in 2020. Weight loss (via diet or bariatric surgery) and vitamin E have recently been demonstrated to be effective treatments of NASH. Although these and other agents may prove to be effective treatments for NASH, the most effective therapeutic strategy would be early screening and intervention to prevent the development of insulin resistance and oxidative stress at a societal level.
The Sacred Emergence of Nature (2009)

Abstract Scientists have had spectacular success with reductionism. Response to this success has been decidedly mixed. On the one hand, people slurp up the technologies and medicines that spin off from, and thereby validate, these reductionist understandings. On the other hand, they often decry the Humpty-Dumpty fragments that appear to be all that remains of their whole-egg world where the human is the point. This article first gives an overview of the emergentist view of nature, and then uses these concepts to outline an emergentist view of the religious quest. It suggests that much of what religious persons seek is grounded in a thirst for the very emergent phenomena that in fact surround us. The concept of emergence, more than any other concept we have encountered, puts Humpty-Dumpty back together again in ways that are wonderfully resonant with our existential and religious yearnings.
On Static Pressure Fluctuation between Sirocco Fan Blades in a Car Air-Conditioning System (2008)

In this study, special attention is directed to static pressure fluctuation in a sirocco fan for a car air-conditioning system, because it is expected that there is a close connection between the fluid noise and the pressure fluctuation. The final purpose of this study is to clarify the relationship between the static pressure fluctuation between fan blades and the sound noise emitted to the outside of the fan, and to develop an air-conditioning system with highly low noise level. For this purpose, first of all, a new micro probe for the measurement of static pressure fluctuation has been developed. This new micro probe is composed of an L-type static pressure tube (the outer diameter is 0.5 mm and the inner diameter is 0.34 mm) and a very small pressure transducer. This probe exhibits a flat frequency response until approximately 2,000 Hz, and it is set between the blades of the fan rotating at 1,500 rpm. The measurements of the static pressure fluctuation between the blades have been performed, and the intensity of sound source was quantified from the second derivative of the phase-averaged static pressure fluctuation signals on the basis of Ribner's formula (Ribner 1962). The experiments have been made in two different modes, i.e., the cooling mode (FACE MODE) and the heating mode (FOOT MODE). It is shown that the static pressure increases rapidly as the blade approaches to the nose of the casing. It is also found that the sound source for FACE MODE shows the larger value than that for FOOT MODE as a whole. In particular, the largest intensity of sound source is observed when the blade approaches to the nose. From these results, it is confirmed that the present new static pressure probe is useful to specify the distributions of sound source in a sirocco fan.
Implementation of a Physical Activity Monitoring System for the Elderly People with Built-in Vital Sign and Fall Detection (2009)

Physical activity monitoring of the elderly people provides valuable information for health aware services. This paper presents the implementation of a system to sense, send, display and store physiology activity. The system includes a wearable device to be worn by the individual to collect physical activity data, a wireless communication link between the patient and the monitoring network. A fall detection and heart beat measurement are also included to provide better monitoring. Testing results show the system function properly and provide accurate fall detection and data for monitoring purpose.
Midterm clinical outcome following Edwards SAPIEN or Medtronic Corevalve transcatheter aortic valve implantation (TAVI): Results of the Belgian TAVI registry (2015)

Cumulative midterm 3 year survival after transfemoral TAVI in "real world" patients refused for surgery with similar baseline EuroSCORE risk profile is not different between SAPIEN or CoreValve.
Reconstruction and uncertainty quantification of lattice Hamiltonian model parameters from observations of microscopic degrees of freedom (2020)

The emergence of scanning probe and electron beam imaging techniques has allowed quantitative studies of atomic structure and minute details of electronic and vibrational structure on the level of individual atomic units. These microscopic descriptors, in turn, can be associated with local symmetry breaking phenomena, representing the stochastic manifestation of the underpinning generative physical model. Here, we explore the reconstruction of exchange integrals in the Hamiltonian for a lattice model with two competing interactions from observations of microscopic degrees of freedom and establish the uncertainties and reliability of such analysis in a broad parameter-temperature space. In contrast to other approaches, we specifically specify a loss function inherent to thermodynamic systems and utilize it to estimate uncertainty in simulated realizations of different models. As an ancillary task, we develop a machine learning approach based on histogram clustering to predict phase diagrams efficiently using a reduced descriptor space. We further demonstrate that reconstruction is possible well above the phase transition and in the regions of parameter space when the macroscopic ground state of the system is poorly defined due to frustrated interactions. This suggests that this approach can be applied to the traditionally complex problems of condensed matter physics such as ferroelectric relaxors and morphotropic phase boundary systems, spin and cluster glasses, and quantum systems once the local descriptors linked to the relevant physical behaviors are known.
Determination of volatile organic compounds in coal, fly ash and slag samples by direct thermal desorption/GC/ms (2000)

This work proposes a method for quantifying volatile organic compounds (VOCs) in coal, fly ash and slag, coming from coal-fired power stations, using direct thermal desorption coupled with gas chromatography (GC) and mass spectrometry (MS) detection. The described method requires practically no sample handling and is precise and sensitive. Aromatic and aliphatic hydrocarbons (benzene, toluene, alkylbenzes, heptane and octane) are the most abundant compounds in these solid samples, coal samples presenting higher levels than fly ash and slag. Other compounds (acids, ketones, aldehydes, limonene, etc.) were identified by mass spectrometry.
Short Communication: Naive CD4 + T Cells and Recent Thymic Emigrant Levels in Treated Individuals with HIV: Clinical Relevance (2006)

An increase in the levels of naive T cells after the administration of HAART is an indicator of the quality of immune reconstitution. We investigated whether levels of naive CD4 T cells (CD4(+)/CD45RA(+)) and of recent thymic emigrants (RTEs; CD4(+)/CD45RA(+)/CD31(+)) achieved in chronically treated HIV-infected patients could predict the length of time patients could interrupt antiretroviral treatment before their CD4 counts reached values < or =350 cells/mm(3) or HIV-1 RNA levels increased to > or =100,000 copies/ml (Tibet cohort). Serial measurements revealed that the level of naive CD4 T cells among patients was extremely variable (5-95%), but the values for each patient remained stable throughout the study. We then focused on those patients who showed percentages of naive CD4 T cells above 60% or below 30%. The levels of naive T cells, RTEs, mononuclear cells containing T cell receptor excision circles (TRECs), and the strength of CD4 helper responses to HIV p24 antigen during treatment failed to predict the duration of treatment interruptions. In contrast, the median survival time of patients with a CD4 nadir > or =350 cells/mm(3) was 2-fold higher than that of patients with a CD4 nadir <350. However, the probability of restarting therapy in these two groups of patients was independent of the levels of naive T cells, RTEs, or TRECs.