gebhart/patrepeval huggingface dataset:
Absolute spectral response measurements of different photodiodes useful for applications in the UV spectral region (2004)

Long UV radiation exposure can result in damages of biological tissues, as burns, skin aging, erythema and even melanoma cancer. In the past years an increase of melanoma cancer has been observed and associated to the atmospheric ozone deployment. Attendance of sun tanning unit centers has become a huge social phenomena, and the maximum UV radiation dose that a human being can receive is regulated by law. On the other side, UV radiation is largely used for therapeutic and germicidal purposes. In all these areas, spectroradiometer and radiomenter are needed for monitoring UVA (315-400 nm), UVB (280-315 nm) and UVC (100-280 nm) irradiance. We have selected some commercial photodiodes which can be used as solid state detectors in these instruments. We have characterized them by measuring their absolute spectral response in the 200 - 400 nm spectral range.
Quinoline-induced chromosome aberrations and sister chromatid exchanges in rat liver (1997)

Induction of chromosome aberrations and sister chromatid exchanges (SCEs) was studied in hepatocytes of F344 rats exposed in vivo to the hepatocarcinogen quinoline (Q). Hepatocytes were isolated 4-48 hr after a single dose of 200 mg/kg body weight or 24 hr after 28 repeated doses (once a day) of 25-200 mg/kg body weight/day by gastric intubation, and allowed to proliferate in Williams' medium E supplemented with epidermal growth factor. Cells were fixed after a culture period of 48 hr. A single dose of Q induced chromosome aberrations in up to 22% of metaphase cells, and SCEs with a frequency of up to 1.27 per chromosome 12 hr after the dose, while the control values were 1% and 0.63 per chromosome, respectively. Treatment with 28 repeated doses of Q induced significant chromosome aberrations and SCEs dose-dependently. Cytogenetic damage induced induced in the liver by repeated doses of Q was greater than induced by a single dose. Furthermore, Q induced replicative DNA synthesis in the liver, but failed to induce micronucleus formation in the bone marrow. The noncarcinogen 8-hydroxyquinoline was also examined and found to be essentially non-genotoxic to rat liver. These results show that Q is a genotoxic carcinogen to rat liver and the present method of in vivo cytogenetic assay should be useful for evaluating the genotoxicity of hepatocarcinogens.
An enhanced 130 nm generation logic technology featuring 60 nm transistors optimized for high performance and low power at 0.7 - 1.4 V (2002)

A leading edge 130 nm technology with 6 layers of Cu interconnects and 1.3 V operation has previously been presented (Tyagi et al., 2000). In this work, we enhance the previous technology with the following: transistor improvements which support a 60 nm gate dimension and increased drive current, improved 6-T SRAM device matching to allow low power and high performance operation from 0.7 to 1.4 V, and a 5% linear shrink to reduce the 6-T SRAM cell to 2.00 /spl mu/m/sup 2/ while still using 248 nm lithography. Saturation drive currents of 1.30 mA//spl mu/m for N-channel and 0.66 mA//spl mu/m for P-channel low VT devices are the highest reported to date. Excellent device short channel effects are obtained for the 60 nm gate length devices as measured by the 270 mV threshold voltage and <100 mV/V DIBL. These results have been achieved on both 200 and 300 mm wafers.
Prediction of histone post-translational modifications using deep learning (2020)

Supplementary data are available at Bioinformatics online.
Platform for benchmarking of RF-based indoor localization solutions (2015)

Over the last few years, the number of indoor localization solutions has grown exponentially, and a wide variety of different technologies and approaches are being explored. Unfortunately, there is currently no established standardized evaluation method for comparing their performance. As a result, each solution is evaluated in a different environment using proprietary evaluation metrics. Consequently, it is currently extremely hard to objectively compare the performance of multiple localization solutions with each other. To address the problem, we present the EVARILOS Benchmarking Platform, which enables automated evaluation and comparison of multiple solutions in different environments using multiple evaluation metrics. We propose a testbed-independent benchmarking platform, combined with multiple testbed-dependent plugins for executing experiments and storing performance results. The platform implements the standardized evaluation method described in the EVARILOS Benchmarking Handbook, which is aligned with the upcoming ISO/IEC 18305 standard “Test and Evaluation of Localization and Tracking Systems.” The platform and plug-ins can be used in real time on existing wireless testbed facilities, while also supporting a remote offline evaluation method using precollected data traces. Using these facilities, and analyzing and comparing the performance of three different localization solutions, we demonstrate the need for objective evaluation methods that consider multiple evaluation criteria in different environments.
Application of Engineered Viral Nanoparticles in Materials and Medicine (2017)

This chapter highlights some unique modification strategies and chemistries that can be applied to virus-based scaffolds to turn them into useful materials with a wide range of applicability. It discusses recent efforts focused on the utilization of virus-based materials for applications in energy-relevant materials, such as battery electrodes and storage devices, and medically-relevant materials, including sensing devices, drug and gene delivery systems, and contrast agents. The chapter then outlines manufacturing protocols, as well as some of the basic engineering protocols and procedures that can be applied to modify and functionalize viral structures for their desired applications. A viral nanoparticle (VNP) is referred when the complete virion is used as a template for functionalization. Finally, the chapter discusses some of the benefits and drawbacks to using VNP and viruslike particle (VLP) platforms in terms of their safety and practicality for use in translational medicine.
VUV test of a new polarimeter for spectropolarimetric measurements on board space missions (2019)

High-resolution spectropolarimetry is a useful astronomical technique, in particular to study stellar magnetic fields. It has been extensively used in the past but mostly in the visible range. Space missions equipped with high-resolution spectropolarimeters working in the ultra-violet (UV) are now being studied. We propose a concept of a polarimeter working with temporal modulation and allowing to perform Stokes IQUV measurements over the full UV + Visible range. The purpose of this article is to describe the polarimeter concept, two prototypes and the bench developed to perform on ground testing to establish the performances of this new polarimeter.
Erratum: Vertical chaos and horizontal diffusion in the bouncing-ball billiard [Phys. Rev. E75, 046214 (2007)] (2007)

Received 7 September 2007DOI:https://doi.org/10.1103/PhysRevE.76.039905©2007 American Physical Society
A Combined Solution and Solid-State Study on the Tautomerism of an Azocalix[4]arene Chromoionophore (2023)

Azocalixarenes functionalized with cation binding sites are popular chromoionophores due to the ease of synthesis and the large complexation-induced shifts of their absorption band that originate from an azo-phenol-quinone-hydrazone tautomerism. Despite their extensive use, however, a thorough investigation of the structure of their metal complexes has not been reported. We describe herein the synthesis of a new azocalixarene ligand (<b>2</b>) and the study of its complexation properties with the Ca<sup>2+</sup> cation. Through a combination of solution (<sup>1</sup>H NMR and UV-vis spectroscopies) and solid-state (X-ray diffractometry) techniques, we demonstrate that metal complexation induces a shift of the tautomeric equilibration towards the quinone-hydrazone form, while deprotonation of the complex results in the reversion to the azo-phenol tautomer.
Total Therapy 3 (TT3) Incorporating VelcadeR (V) Intro Upfront Management of Multiple Myeloma (MM): Comparison with TT2 + Thalidomide (T). (2005)

Abstract Background: V effects partial responses in 1/3 of patients with advanced and refractory MM and was more effective when combined with T/dexamethasone (D) in our VTD regimen (Barlogie et al. Blood2004; 103: 20). TT3 was designed to build on the success of TT2 by providing T to all patients and incorporating V in induction, consolidation and maintenance therapies to increase CR to 60% and 2-yr EFS for patients with normal/abnormal metaphase cytogenetics to 95% /75%. Patients and Methods: TT3 consists of 2 induction cycles with VDT-PACE (PBSC collection after the first cycle), followed by melphalan 200mg/sqm-based tandem transplants with peri-transplant T+D, 2 consolidation cycles with VDT-PACE, 1 year maintenance with VTD and 2 years with T+D. Of the 162 patients enrolled prior to 4/20/2005, 156 completed induction therapy, 147 the first and 113 the second transplant. Response rates, toxicities during induction, and stem cell collection results were compared with 314 TT2+T patients. Results: First and second transplant on TT3 were completed faster, at medians of 3 and 5 mo, compared to 5 and 10 mo, respectively, on TT2+T (p&amp;lt;0.001/p&amp;lt;0.001); 92%/78% (TT3) vs 89%/68% (TT-2+T) completed first and second transplant, respectively, (p0.24/p=0.028). The probability of achieving near-CR (n-CR: only immunofixation positive) at 12 mo was 81% with TT3 and 64% with TT2+T (p=.001). The median number of CD34/kg (x106) was 27 with TT3 vs 20 with TT2+T (p&amp;lt;.001). Treatment-related mortality (TRM) at 12 mo was 4% with TT3 and 6% TT2+T (p=.3). With a median follow-up of 9 mo, 18 patients have experienced an event and 14 have died (disease-related 7; treatment-related 6, other 1). Compared to event-free TT3 patients, these 18 patients were older (≥ 65 years: 50% vs 27%; p=0.04), more frequently had metaphase abnormalities (50% vs 24%; p=0.02) and had elevated LDH (50% vs 19%; p=0.003). With respect to grade 3–4 toxicities during induction, TT3 patients had fewer thrombo-embolic events, (p&amp;lt;.001), less febrile neutropenia (p=.03), somnolence (p=.007), sensory neuropathy (.005) and dizziness (&amp;lt; .001), but more anorexia (p&amp;lt; .001) and renal insufficiency (p=.004). Conclusion: TT3 appears to be more effective in inducing ≥ n-CR, compared to TT-2+T, partly due to a higher percentage of patients completing the intended 2 transplants. TRM is not different. It is too early to assess the true CR rate and the 2-y EFS according to cytogenetics.
Human Hair Follicles: Metabolism and Control Mechanisms* (1970)

TESTOSTERONE metabolism, and the ADENYL CYCLASE system of human hair follicles suggest the following mechanisms of transformation of the hair follicles from the terminal to the veilus type: Testosterone carried in plasma reaches the hair follicles, where it is converted to 5a-dihydrotestosteronc, a tissue-active androgen. Since the hair follicles have sufficient 5a-reductase to catalyze this conversion, the intracellular level of TPNH is presumed to be the rate-limiting factor at this step. The growing hair follicles appear to generate sufficient TPNH via the penrose cycle. Probably 5a-dihydrotestosterone but not testosterone is the tissue-active androgen, since adenyl cyclase in the hair follicles is markedly inhibited by 5a-dihydrotestosterone but not by testosterone. Inhibition of adenyl cyclase decreases the intracellular level of cyclic AMP. This decrease of cyclic AMP, in turn, will create premature completion of the anagen state. Years of repetition of this premature completion probably produces the short veilus-type hairs and hair follicles. Although solid proof for the entire process of BALDNESS is not yet available, the initial roles played by 5a-dihydrotestosterone and adenyl cyclase are highly significant in these complex mechanisms.
Flavonoiden en preventie van chronische zieketen : waar staan we nu? (2005)

Er zijn steeds meer aanwijzingen dat flavonoiden in de voeding, die veel voorkomen in thee, wijn, groente en fruit, beschermen tegen hart- en vaatziekten en kanker. De aanwijzingen zijn het sterkst als het gaat om hart- en vaatziekten, maar zijn indirect. Tot nu toe is met geisoleerde flavonoiden alleen op ruime schaal in vitro-onderzoek gedaan, maar de tijd lijkt rijp te zijn voor een grote interventiestudie bij mensen
A Regioselective Synthesis of 2,4‐Dialkyl Resorcinols. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
HPMA copolymer–phospholipase C and dextrin–phospholipase A2 as model triggers for polymer enzyme liposome therapy (PELT) (2017)

'Polymer Enzyme Liposome Therapy' (PELT) is a two-step anticancer approach in which a liposomal drug and polymer-phospholipase conjugate are administered sequentially to target the tumour interstitium by the enhanced permeability and retention effect, and trigger rapid, local, drug release. To date, however, the concept has only been described theoretically. We synthesised two polymer conjugates of phospholipase C (PLC) and A2 (PLA2) and evaluated their ability to trigger anthracycline release from the clinically used liposomes, Caelyx<sup>®</sup> and DaunoXome<sup>®</sup>. N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer-PLC and a dextrin-PLA2 were synthesised and their enzymatic activity characterised. Doxorubicin release from polyethyleneglycol-coated (PEGylated) Caelyx<sup>®</sup> was relatively slow (<20%, 60 min), whereas daunomycin was rapidly released from non-PEGylated DaunoXome<sup>®</sup> (∼87%) by both enzymes. Incubation with dextrin-PLA2 triggered significantly less daunomycin release than HPMA copolymer-PLC, but when dextrin-PLA2 was pre-incubated with α-amylase, the rate of daunomycin release increased. DaunoXome<sup>®'</sup>s diameter increased in the presence of PLA2, while Caelyx<sup>®</sup>'s diameter was unaffected by free or conjugated PLA2. Dextrin-PLA2 potentiated the cytotoxicity of DaunoXome<sup>®</sup> to MCF-7 cells to a greater extent than free PLA2, while combining dextrin-PLA2 with Caelyx<sup>®</sup> resulted in antagonism, even in the presence of α-amylase, presumably due to steric hindrance by PEG. Our findings suggest that in vivo studies to evaluate PELT combinations should be further evaluated.
Automated Interactive Sales Processes (2010)

The paper mentions that an automated interactive sales process can combine aggregate anonymous knowledge of customer preferences with specific data about the ongoing negotiation process with the current customer.
Measurement-based Characterization of Human Body Impact on Ultra-low UAV-to-Ground Channels (2021)

At ultra-low altitudes, an unmanned aerial vehicle (UAV) can act as a personal base station, where it communicates only with one user, as in the case of a UAV-assisted soldier. User equipment (UE) can be inside the pocket of a user or near their chest while facing or facing-away from the UAV. In these scenarios, the wireless channel can experience different fading levels based on the UAV&#x0027;s hovering position, user orientation, location of the UE near the user&#x0027;s body, and carrier frequency of the transmitted signal. In this work, we provide measurement results and study how the human body affects the Air-to-Ground (AtG) channel characteristics under various use cases of holding a UE device. These channel characteristics include the average signal strength, shadowing, and Rician K-factor. We target three different ways in which the device is held by the user: Near-Chest Facing, In-pocket Facing, and Near-Chest Facing-away from the transmitting UAV. We perform this study at carrier frequencies of 900 MHz and 2.5 GHz and in Line-of-Sight (LOS) conditions. First, we conduct a set of baseline experiments to understand AtG channels in free space with no human involved. Second, we conduct AtG experiments with the user holding the device and show that the human body can induce either gains or losses compared to free space, depending on the user orientation with respect to the UAV. Third, we find that there are two distinct regions of operation, one in which the channel characteristics are mainly affected by the UAV and another that is dominated by the user&#x0027;s body. The obtained results help create more realistic 3D UAV-to-ground channel models and complement adaptive aerial drone deployment algorithms that target making intelligent decisions about trajectory and energy consumption when considering human body effects.
ChemInform Abstract: Thiophenol‐Mediated 1,5‐Hydrogen Transfer for the Preparation of Pyrrolizidines, Indolizidines, and Related Compounds. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Röntgenologische Bestimmung des Herzvolumens der Ratte (1963)

Abstract A method for X‐ray determination of the heart volume of rats is described. Using general anesthesia the heart was X‐rayed in the frontal and sagittal planes. The relative volume of the heart, calculated from the length, breadth and depth was multiplied by the correction factor of 0.44 to obtain the absolute volume. The correction factor has been estimated by empirical analysis in heart models. The relationship between length (a), breadth (b) and the square of depth (c). i.e c 2 /a×b; does not change during growth. The standard error of estimate for a single determination calculated from 168 duplicated determinations was 7.3 %.
Global existence for a kinetic model of chemotaxis via dispersion and Strichartz estimates (2007)

We investigate further the existence of solutions to kinetic models of chemotaxis. These are nonlinear transport-scattering equations with a quadratic nonlinearity which have been used to describe the motion of bacteria since the 80's when experimental observations have shown they move by a series of 'run and tumble'. The existence of solutions has been obtained in several papers [Chalub et al. Monatsh. Math. 142, 123--141 (2004), Hwang et al. SIAM J. Math. Anal. 36, 1177--1199 (2005)] using direct and strong dispersive effects. Here, we use the weak dispersion estimates of [Castella et al. C. R. Acad. Sci. Paris 322, 535--540 (1996)] to prove global existence in various situations depending on the turning kernel. In the most difficult cases, where both the velocities before and after tumbling appear, with the known methods, only Strichartz estimates can give a result, with a smallness assumption.
755: MAKING COMPUTERS READ ICU DISCHARGE SUMMARIES: DISCHARGE DISPOSITION AND NEUROLOGIC OUTCOMES VIA NLP (2019)

Fernandes, Marta1,,2,,3; Tabaeizadeh, Mohammad4; Nour, Hassan Aboul4; Shoukat, Maryum5; Javed, Farrukh4; Kassa, Solomon6; Edhi, Muhammad4; Bordbar, Elahe4; Gallagher, Justin4; Zafar, Sahar7; Rosenthal, Eric8; Westover, M.9 Author Information
Verankerung von Funktionsfarbstoffen in MCM-41 durch mikrowellenunterstützte hydrothermale Cokondensation (2000)

Kovalent anbinden lassen sich hydrolyseempfindliche Funktionsfarbstoffe an mesoporöse Silicate des Typs Si-MCM-41 (siehe Bild) durch die hier vorgestellte Mikrowellensynthese. Die kurze Reaktionszeit (20 min) minimiert Abbaureaktionen des Farbstoffs während der Hydrothermalsynthese.
A CDMA-based Medium Access Control for UnderWater Acoustic Sensor Networks (2009)

UnderWater Acoustic Sensor Networks (UW-ASNs) consist of sensors and Autonomous Underwater Vehicles (AUVs) performing collaborative monitoring tasks. In this article, UWMAC, a distributed Medium Access Control (MAC) protocol designed for UW-ASNs, is introduced. The proposed MAC protocol is a transmitter-based Code Division Multiple Access (CDMA) scheme that incorporates a novel closed-loop distributed algorithm to jointly set the optimal transmit power and code length. CDMA is the most promising physical layer and multiple access technique for UW-ASNs because it is robust to frequency-selective fading, it compensates for the effect of multipath at the receiver, and it allows receivers to distinguish among signals simultaneously transmitted by multiple devices. UW-MAC aims at achieving three objectives, i.e., guarantee i) high network throughput, ii) low channel access delay, and iii) low energy consumption. It is demonstrated that UW-MAC simultaneously achieves these three objectives in deep water communications (where the ocean depth is more than 100 m), which are usually not severely affected by multipath. In shallow water communications, which may be heavily affected by multipath, it dynamically finds the optimal trade-off among these objectives according to the application requirements. UW-MAC is the first protocol that leverages CDMA properties to achieve multiple access to the scarce underwater bandwidth, while other protocols tailored for this environment have considered CDMA merely from a physical layer perspective. Experiments show that UW-MAC outperforms many existing MAC protocols tuned for the underwater environment under different architecture scenarios and simulation settings.
Distributed Mixers with Composite Right/Left-Handed Transmission Lines (2006)

The use of composite right/left-handed transmission lines (CRLH-TLs) in distributed mixers, instead of the usual right-handed transmission lines (RH-TLs) is explored. The theoretical performance of such mixers is analyzed in two cases: when CRLH-TLs are used in both drain and gate lines, and when a CRLH-TL is introduced only in the gate line. Both cases show that innovative distributed mixer designs can be achieved. In one design the IF is output on a different port for the different RF frequencies, and in another design there is an intrinsic image frequency rejection achieved
The use of Laplace transforms in the simulation of power system frequency transients (1975)

The differential equations describing a frequency transient are solved in the Laplace domain: a numerical inverse transformation method is used in conjunction with an iterative technique to account for system nonlinearities. This method has the advantage of "filtering out" synchronizing oscillations between individual machines, thus speeding up the solution process. If a complete numerical integration time-domain solution is needed the S-domain method can be used to 1) assess directly the sensitivity of the solution to changes in the model, thus enabling model reduction. 2) determine regions with common average frequency.
Pharmacokinetics-Pharmacodynamics of Rifampin in an Aerosol Infection Model of Tuberculosis (2003)

Limited information exists on the pharmacokinetic (PK)-pharmacodynamic (PD) relationships of drugs against Mycobacterium tuberculosis. Our aim was to identify the PK-PD parameter that best describes the efficacy of rifampin on the basis of in vitro and PK properties. Consistent with 83.8% protein binding by equilibrium dialysis, the rifampin MIC for M. tuberculosis strain H37Rv rose from 0.1 in a serum-free system to 1.0 mg/ml when it was tested in the presence of 50% serum. In time-kill studies, rifampin exhibited area under the concentration-time curve (AUC)-dependent killing in vitro, with maximal killing seen on all days and with the potency increasing steadily over a 9-day exposure period. MIC and time-kill studies performed with intracellular organisms in a macrophage monolayer model yielded similar results. By use of a murine aerosol infection model with dose ranging and dose fractionation over 6 days, the PD parameter that best correlated with a reduction in bacterial counts was found to be AUC/MIC (r(2) = 0.95), whereas the maximum concentration in serum/MIC (r(2) = 0.86) and the time that the concentration remained above the MIC (r(2) = 0.44) showed lesser degrees of correlation.